bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile synthesis of hydroxyapatite nanoparticles from eggshell biowaste usingAzadirachta indicaextract as a green template
Authors: Upadhyay Punita , Ullah Aman 
Published: June 2023

Hydroxyapatite nanoparticles (HANPs) were successfully synthesized from eggshell waste by microwave-assisted (MW) as well as conventional heating precipitation methods and a green template i.e., Azadirachta indica (AI) (neem) leaf extract.
Mammakarzinom beim Mann
Authors: Preuss Caroline , Wunderle Marius , Hack Carolin C. , Beckmann Matthias W. , Wenkel Evelyn , Jud Sebastian Michael , Heindl Felix 
Published: June 2023

ZusammenfassungMännlicher Brustkrebs ist für viele Ärzte ein unbekanntes Gebiet. Die Patienten gehen oft zu verschiedenen Ärzten, bevor die richtige Diagnose gestellt wird – meist zu spät. Dieser Artikel soll Risikofaktoren sowie die Einleitung von Diagnostik und Therapie aufzeigen. Im anbrechenden Zeitalter der molekularen Medizin werden wir auch einen Blick auf die Genetik werfen.
Assessment of the Degree of Clinical Suspicion of 21-Hydroxylase
Deficiency Prior to the Newborn Screening Result
Authors: Sanz Fernández María , Mora Sitja Marina , Carrascón González-Pinto Lucía , López Herce Arteta Estíbaliz , Rodríguez Sánchez Amparo 
Published: June 2023

AbstractThe aim of the study was to analyze the clinical suspicion and where patients
were when they received the positive result of the neonatal screening for CAH
21OHD. The present data derived from a retrospective analysis of a relatively
large group of patients with classical CAH 21OHD patients nosed by newborn
screening in Madrid, Spain. During the period from 1990 to 2015 of this study 46
children were diagnosed with classical 21OHD [36 with the salt-wasting (SW) form
and 10 with simple virilizing (SV)]. In 38 patients, the disease had not been
suspected before the neonatal screening result (30 SW and 8 SV). Thirty patients
(79%) were at home without suspicion of any disease, as healthy
children, 3 patients (8%) were at home pending completion of the study
due to clinical suspicion of any disease (ambiguous genitalia, cryptorchidism)
and 5 patients (13%) were admitted to the hospital for reasons unrelated
to CAH (sepsis, jaundice, hypoglycemia). It is relevant to note that
69.4% of patients (25/36) with SW form were at home with
potential risk of adrenal crisis. Six females had been incorrectly labeled as
male at birth. The most frequent reason for clinical suspicion was genital
ambiguity in women followed by family history of the disease. Neonatal screening
provided better results than clinical suspicion. In the majority of patients
with 21OHD the diagnosis by screening was anticipated to the clinical suspicion
of the disease even in female patients with ambiguous genitalia.
Bilateral Percutaneous Transpedicular Drainage under Local Anesthesia for Thoracic Tuberculous Spondylitis
Authors: Maki Yoshinori , Takayama Motohiro , Go Kohichi 
Published: June 2023

AbstractTuberculous spondylitis is a common spinal infection. If surgical intervention is necessary, anterior debridement and anterior fixation are typically performed. However, a minimally invasive surgical strategy under local anesthesia seems rarely implemented.A 68-year-old man presented with severe pain in the left flank. Whole spinal magnetic resonance imaging revealed abnormal intensity of vertebral bodies from T6–9. A bilateral paravertebral abscess extending from T4–10 was suspected. The T7/T8 intervertebral disc was destroyed, but severe vertebral deformity or spinal cord compression was not observed. Bilateral percutaneous transpedicular drainage under local anesthesia was planned. The patient was set in the prone position. Under the guide of a biplanar angiographic system, the bilateral drainage tubes were placed paravertebrally in the abscess cavity. The left flank pain improved after the procedure. Laboratory culture of the pus specimen confirmed a diagnosis of tuberculosis. A chemotherapy regimen for tuberculosis was soon initiated. The patient was discharged during postoperative week 2, with continuation of chemotherapy for tuberculosis.Percutaneous transpedicular drainage under local anesthesia can be effective in the management of thoracic tuberculous spondylitis without severe vertebral deformity or compression of the spinal cord by an abscess.
Effect of Multimodal Intervention on Cancer-Related Fatigue and Quality of Life among Patients Undergoing Cancer Treatment—Pilot Study (Part 1)
Authors: Shambhavi Shambhavi , Lobo Diana 
Published: June 2023

Abstract
Background Cancer-related fatigue (CRF) is the most common and devastating problem in cancer patients even after successful treatment. CRF has a severe impact on daily activities, social relationships, reintegration, and overall quality of life (QOL).
Objective This study was done to evaluate the effect of multimodal intervention (MMI) on CRF and QOL among cancer patients undergoing cancer treatment.
Materials and Methods One group before-and-after study (pre-experimental design) was conducted among cancer patients undergoing cancer treatment who met inclusion criteria and were selected using a purposive sampling technique, in selected hospitals. MMI consisted of exercise program, acupressure, and home care management guide. Pre-test CRF and QOL were assessed on first day using a FACIT-F scale (Functional Assessment of Chronic Illness Therapy: Fatigue) and Functional Assessment of Cancer Therapy: Fatigue (FACT-G) Version 4, respectively. Post- test for CRF was further determined after 7 days, 21 days, and 3months and QOL was determined after 21 days and 3 months.
Statistical Analysis Demographic and clinical characteristics of the participants are presented as frequency and percentage. Comparison of pre- test and post-test means of CRF and QOL is done by repeated measures analysis of variance (ANOVA). Correlation between fatigue and QOL of cancer patients was found by using Pearson correlation test.
Results The mean pre-test fatigue score of the cancer patients (pre-test mean= 25.21) was lower than their mean post-test fatigue scores (post-test 1 =25.83, post-test 2 = 28.28, and post-test 3 = 34.72). There was a significant difference in CRF and QOL scores between before and after the MMI. In the repeated measures ANOVA, p-value is less than 0.05 (level of significance p < 0.05).
Conclusion Regardless of mechanism of occurrence of fatigue, most patients living with cancer suffer with persistent CRF. Yet it is often not assessed, has limited treatment options, there is a need to assess the state of fatigue in cancer patients. They do need intervention to reduce the fatigue and to improve the QOL. Nonpharmacological therapies are the best strategies to manage the fatigue among cancer patients without any safety issue.
Aortoiliac: Covered, Uncovered, CERAB as It Relates to Peripheral Arterial Disease
Authors: Bozorghadad Sayeh , Scheidt Matthew J. , Patel Parag J. 
Published: June 2023

AbstractPeripheral arterial disease (PAD) affects over 200 million worldwide and is the leading cause of major limb amputation, with individuals suffering from PAD being at three times greater risk of dying compared with matched controls. TASC-II guidelines provide a consensus on the management of PAD based on the collaboration between international vascular specialties. These guidelines previously outlined open surgery as the gold standard for treatment of aortoiliac disease and PAD as it has demonstrated consistent long-term results. However, this approach is also associated with high perioperative mortality, especially when compared with endovascular techniques. With recent developments in endovascular technology, user technique, and experience, this approach has become more widely used as primary intervention for aortoiliac disease. One of these novel techniques includes covered endovascular reconstruction of the aortic bifurcation, which has demonstrated excellent technical success and improved primary and secondary patency rates with follow-up. The aim of this review is to compare the efficacy of these approaches to the treatment of aortoiliac disease and demonstrate the benefits of the shift toward an endovascular-first approach to treatment of this disease, regardless of lesion complexity or severity.
Case Report with a Review of Literature: Pancoast Syndrome—A Rare Presentation of Metastatic Hepatocellular Carcinoma
Authors: Singuluri Lakshmi Sandhya , Ganesan Prasanth , Srinivas Bheemanathi Hanuman , Dubashi Biswajit , Nisha Yadav 
Published: June 2023

AbstractSuperior sulcus tumors, also known as Pancoast tumors, present in a distinctive way with Horner's syndrome (ptosis, miosis, and anhidrosis), hand weakness brought on by the atrophy of the intrinsic hand muscles, and excruciating pain along the medial aspect of the arm. (1) Primary lung cancers constitute a majority of Pancoast tumors, but Pancoast syndrome can be multifactorial. (2) Here, we present a case of 62-year-old male who presented with right shoulder pain and weakness for 2 months. Clinically, he had a supraclavicular mass with atrophy of the intrinsic muscles of the hand and sensory-motor weakness. Computed tomography showed a mass lesion in the supraclavicular fossa with the erosion of the T1 vertebra and first rib, mimicking carcinoma right upper lobe. However, the biopsy from the mass was suggestive of metastasis from hepatocellular carcinoma (HCC). Our case report identifies HCC as a rare differential for Pancoast syndrome and highlights the unique metastatic presentation.
Anxiety and Depression Symptoms of Family Members of Intensive Care Unit Patients: A Prospective Observational Study and the Lived Experiences of the Family Members
Authors: Gurbuz Hande , Demir Nalan 
Published: June 2023

Abstract
Background The aim of this study is to investigate the factors affecting symptoms of anxiety and depression in the family members of critically ill patients.
Methods This prospective cohort study was conducted in an adult tertiary care mixed medical–surgical intensive care unit (ICU) at a tertiary-level teaching hospital. The symptoms of anxiety and depression of first-degree adult relatives were evaluated with the Hospital Anxiety and Depression Scale. Four family members were interviewed and asked about their experiences during the ICU process.
Results A total of 84 patients and their family members were included in the study. The symptoms of anxiety were present in 44/84 (52.4%), and depression was present in 57/84 (67.9%) family members. A nasogastric tube was found to be related to anxiety (p = 0.005) and depressive symptoms (p = 0.002). The family members of the patients with an acute developed illness had 3.9 (95% confidence interval [CI]: 1.4–10.9) times the odds of having the symptoms of anxiety and 6.2 (95% CI: 1.7–21.7) times the odds of having the symptoms of depression than the family members of the patients with an illness developed on a chronic basis. The family members of the patients who died in the ICU had 5.0 (95% CI: 1.0–24.5) times the odds of being depressed than the patients discharged from the ICU. All interviewees stated having difficulty understanding and remembering what was told. The common feelings of all the interviewees were desperation and fear.
Conclusions Awareness of the emotional stress of family members can help develop interventions and attitudes to alleviate symptom burden.
Effects of Recombinant SARS-CoV-2 Spike Protein Variants on Platelet Morphology and Activation
Authors: Vettori Marco , Carpenè Giovanni , Salvagno Gian Luca , Gelati Matteo , Dima Francesco , Celegon Giovanni , Favaloro Emmanuel J. , Lippi Giuseppe 
Published: June 2023

AbstractPlatelets are central elements of hemostasis and also play a pivotal role in the pathogenesis of thrombosis in coronavirus disease 2019. This study was planned to investigate the effects of different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recombinant spike protein variants on platelet morphology and activation. Citrated whole blood collected from ostensibly healthy subjects was challenged with saline (control sample) and with 2 and 20 ng/mL final concentration of SARS-CoV-2 recombinant spike protein of Ancestral, Alpha, Delta, and Omicron variants. Platelet count was found to be decreased with all SARS-CoV-2 recombinant spike protein variants and concentrations tested, achieving the lowest values with 20 ng/mL Delta recombinant spike protein. The mean platelet volume increased in all samples irrespective of SARS-CoV-2 recombinant spike protein variants and concentrations tested, but especially using Delta and Alpha recombinant spike proteins. The values of both platelet function analyzer-200 collagen-adenosine diphosphate and collagen-epinephrine increased in all samples irrespective of SARS-CoV-2 recombinant spike protein variants and concentrations tested, and thus reflecting platelet exhaustion, and displaying again higher increases with Delta and Alpha recombinant spike proteins. Most samples where SARS-CoV-2 recombinant spike proteins were added were flagged as containing platelet clumps. Morphological analysis revealed the presence of a considerable number of activated platelets, platelet clumps, platelet-monocyte, and platelet-neutrophils aggregates, especially in samples spiked with Alpha and Delta recombinant spike proteins at 20 ng/mL. These results provide support to the evidence that SARS-CoV-2 is capable of activating platelets through its spike protein, though such effect varies depending on different spike protein variants.
The Frequency of SMN1, SMN2 Copy Numbers in 246 Turkish Cases Analyzed with MLPA Method
Authors: Yalcintepe Sinem , Karal Yasemin , Demir Selma , Atli Emine Ikbal , Atli Engin , Eker Damla , Mail Cisem , Zhuri Drenushe , Guler Hazal Sezginer , Gurkan Hakan 
Published: June 2023

AbstractThis study aimed to define the copy numbers of SMN1 and SMN2 genes and the diagnosis rate and carrier frequency of spinal muscular atrophy (SMA) in the Thrace region of Turkey. In this study, the frequency of deletions in exons 7 and 8 in the SMN1 gene and SMN2 copy numbers were investigated. A total of 133 cases with the preliminary diagnosis of SMA and 113 cases with the suspicion of being an SMA carrier from independent families were analyzed by multiplex ligation-dependent probe amplification method for SMN1 and SMN2 gene copy numbers.
SMN1 homozygous deletions were detected in 34 patients (25.5%) of 133 cases with the suspicion of SMA. Cases diagnosed with SMA type I was 41.17% (14/34), 29.4% (10/34) with type II, 26.4% (9/34) with type III, and 2.94% (1/34) with type IV. The SMA carrier rate was 46.01% in 113 cases. In 34 SMA cases, SMN2 copy numbers were: two copies – 28 cases (82.3%), three copies – 6 cases (17.6%). SMN2 homozygous deletions were detected in 15% (17/113) of carrier analysis cases. The consanguinity rate of the parents was 23.5% in SMA diagnosed cases. In this study, we had a 25.5% of SMA diagnosis rate and 46% SMA carrier frequency. The current study also showed the relatively low consanguinity rate of the Thrace region, with 23.5% according to the east of Turkey.
Below-the-Knee Stents and Scaffolds: A Comprehensive Review
Authors: Dadrass Farnaz , Raja Sahitya C. , Lookstein Robert 
Published: June 2023

AbstractBelow-the-knee intervention of chronic limb-threatening ischemia is an area of increasing interest. Due to lower morbidity and possibly better clinical outcomes, endovascular techniques have become increasingly important in this patient population many of who have limited surgical options. This article serves as a review of existing stent and scaffolding devices utilized for infrapopliteal disease. The authors will additionally discuss current indications and review studies that are investigating novel materials used in treating infrapopliteal arterial disease.
Peripheral Arterial Disease Treatment in the Non-Hospital Setting
Authors: Wiechmann Bret N. 
Published: June 2023

AbstractTreatment of peripheral artery disease (PAD) has undergone a progressive shift toward less invasive, endovascular options within the last three decades. For PAD patients, the benefits of this shift are numerous and include less periprocedural pain, decreased blood loss, shorter recovery times, and fewer missed workdays. Commonly, patient-reported outcomes are very positive with this “endovascular first” strategy and the number of open surgical procedures for various stages of PAD has declined steadily over the last 20 years. Coincident with this trend is the move toward “ambulatory” lower extremity arterial intervention (LEAI) in the hospital outpatient “same-day” department. The next logical extension was then performing LEAI in a true physician office-based lab (OBL), ambulatory surgical center (ASC), or “non-hospital setting.” This article examines these trends and the concept that the OBL/ASC provides a safe, alternative site of service for PAD patients requiring LEAI.
Co-management for sustainable development and conservation in Sanjiangyuan National Park and the surrounding Tibetan nomadic pastoralist areas
Authors: Ma Ting , Swallow Brent , Foggin J. Marc , Zhong Linsheng , Sang Weiguo 
Published: June 2023

AbstractThe Qinghai-Tibet Plateau plays an essential role in national to regional ecological security, biodiversity conservation, and sustaining livelihood. An array of natural resource management, environmental conservation, and ecological restoration projects have been trialed and implemented in recent years in the vast Sanjiangyuan region of the central Qinghai-Tibet Plateau, aiming especially to ensure socio-ecologically appropriate and sustainable development of animal husbandry in the alpine grasslands. Novel approaches in China have included the introduction of more collaborative approaches in protected area management and the development and formal establishment of a new multi-purpose national park system. Many milestones have been achieved. However, such developments are driven largely by national and global goals and very little has been heard to date directly from the people most affected: those residing within the protected landscapes, i.e. the community stakeholders themselves. This empirical, perceptions-based study aims to partially fill this gap, drawing on the results of focus group discussions with community representatives supplemented by key informant interviews and a targeted review of the literature, to provide synthesized feedback and priority recommendations for improving “community co-management” collaborations for the joint benefit of Tibetan herders and protected areas. The mixed-method approach employed in this study was based on a conceptual model derived from Elinor Ostrom’s social–ecological systems framework, calibrated to local residents’ self-assessments of their household well-being. Results highlight how the most recent configuration of China’s national park model (i.e., its form and the approaches it utilizes) is generally deemed successful by community stakeholders, albeit with some notable perceived limitations mainly relating to a sense of lack of fairness and inclusiveness in the “one household, one post” co-management mechanism. The paper closes with discussion and recommendations around fundamental issues of equity, empowerment, and gender, finally pointing to the significance and, ultimately, the need to move even beyond co-management per se and to adopt a model of inclusive governance for conservation wherein joint deliberations and decision-making amongst diverse stakeholders are prioritized over the simple implementation of externally developed programs and management plans.
60 Gbps real-time wireless communications at 300 GHz carrier using a Kerr microcomb-based source
Authors: Heffernan Brendan M. , Kawamoto Yuma , Maekawa Keisuke , Greenberg James , Amin Rubab , Hori Takashi , Tanigawa Tatsuya , Nagatsuma Tadao , Rolland Antoine 
Published: June 2023

Future wireless communication infrastructure will rely on terahertz systems that can support an increasing demand for large-bandwidth, ultra-fast wireless data transfer. In order to satisfy this demand, compact, low-power, and low noise sources of terahertz radiation are being developed. A promising route to achieving this goal is combining photonic-integrated optical frequency combs with fast photodiodes for difference frequency generation in the THz. Here, we demonstrate wireless communications using a 300 GHz carrier wave generated via photomixing of two optical tones originating from diode lasers that are injection locked to a dissipative Kerr soliton frequency microcomb. We achieve transfer rates of 80 Gbps using homodyne detection and 60 Gbps transmitting simultaneously both data and clock signals in a dual-path wireless link. This experimental demonstration paves a path toward low-noise and integrated photonic millimeter-wave transceivers for future wireless communication systems.
Influence of external environment parameters on friction coefficient between hoisting-rope and its pads
Authors: Kou Baofu , Li Zhenshun , Li Ruiqing , Wang Zhaohua , Zhao Xinlin 
Published: June 2023

The friction coefficients between the hoisting-rope and friction pads made of different materials under different environmental conditions, load sizes, and load frequencies were investigated by using a friction and wear tester. The variation law of the friction coefficient with the change in the working condition parameters was explored through orthogonal test analysis; it is found that dry friction, a load of 100 N, and a frequency of 1 Hz are the optimal working conditions to achieve an optimal friction coefficient of the matching pair of the hoisting-rope and friction pads. Among them, the friction coefficient of the K25 pad is greatly affected by the environment, while the friction coefficient of the G30 pad is greatly affected by load. The results under all working conditions show that the friction coefficient of the K25 pad is greater than that of the G30 pad but the wear resistance of the G30 pad is better than that of the K25 pad. In terms of wear resistance, the K25 pad performs better under dry friction conditions than under other environmental conditions, while the G30 pad performs better under rain conditions. The conclusion can provide theoretical guidance for the reasonable matching between the hoisting-rope and its pads under different environmental conditions.
Historic and physical wandering domains for wild blender-horseshoes
Authors: Kiriki Shin , Nakano Yushi , Soma Teruhiko 
Published: June 2023

Abstract
We present diffeomorphisms of wild blender-horseshoes which belong to

C
r

(
1
⩽
r
<
∞
)

closures of two types of diffeomorphisms, one of which has a historic contracting wandering domain, and the other has a non-trivial Dirac physical measure supported by saddle periodic orbit. It is a non-trivial extension of Colli–Vargas’ model (Colli and Vargas 2001 Ergod. Theory Dyn. Syst.
21 1657–81) to the higher dimensional dynamics with the use of wild blender-horseshoes.
Transport properties of
Fe60Al40
during the
B2
to
A2
structural phase transition
Authors: Sorokin Serhii , Anwar Md Shadab , Hlawacek Gregor , Boucher Richard , Salgado-Cabaco João , Potzger Kay , Lindner Jürgen , Faßbender Jürgen , Bali Rantej 
Published: June 2023

Abstract
The variation of transport behavior in a mesoscopic

F
e

60

A
l

40

wire, initially possessing the ordered

B
2

-phase structure, has been observed while inducing a phase transition to the disordered

A
2

phase. Gradual disordering was achieved using a highly focused beam of

N
e

+

-ions. Both electrical resistance and anomalous Hall effect were measured simultaneously and in situ during the local ion irradiation. The normal as well as the Hall resistivity show a peak as a function of disorder. The relationship between Hall resistivity and normal resistivity shows the presence of two distinct transport regimes during the phase transition. Ex situ field- and temperature-dependence measurements show that it is necessary to consider the effect of scattering from magnetic clusters to understand these different regimes in transport properties.