bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of Skin Graft Techniques with and without Plaster Back Slab Dressing in Reducing Donor Site Morbidity in Radial Forearm Free Flap Surgery - A Retrospective Study
Authors: Lakshmiah Sundarraj , Ko Yuiyin , Mair Manish , Baker Andrew , Ameerally Phillip 
Published: August 2023

Abstract

Introduction:
The radial forearm free flap (RFFF) is a commonly used free flap for the reconstruction of orofacial defects because of its versatility and reliability. The donor site is closed with either split or full-thickness skin graft, and one of the common donor site morbidities is skin graft failure. Various techniques to minimise skin graft failure were reported, and we compared the skin graft techniques with and without plaster back slab dressing in the radial forearm donor site.

Materials and Methods:
This is a retrospective study of 75 patients who had RFFF for reconstruction of oral cavity cancer at two different tertiary teaching hospitals in the United Kingdom between April 2015 and March 2020. Thirty-nine patients from Hospital one had volar back slap, bolster dressing and crepe bandage. In contrast, 36 patients from Hospital two had only pressure dressing without a back slab.

Results:
The mean age of the study population was 60.65 (P = 0.274). In both groups, two patients had donor site complications. However, there was no significant difference in the donor site skin graft complications with a P = 0.662.

Discussion:
There was no evidence in the literature to support an ideal bandage for skin graft at the RFFF donor site. Our comparison of two techniques of skin graft dressings with and without back slap did not show any difference in the skin graft take, and the volar back slab did not add any additional benefits. The simple use of foam as a bolster dressing without a back slab is ideal for the radial forearm free flap donor site.
Nebivolol and Atenolol Roles in Doxorubicin-Induced Cardiotoxicity
Authors: Issa Hajer Kays , Al-Gareeb Ali Ismail 
Published: August 2023

Background:
This study investigated the potential role of ivabradine (Nebivolol and Atenolol) in the attenuation of doxorubicin induced cardiotoxicity in mice. So we will seek the role of nebivolol and atenolol in reducing cardiotoxicity induced by doxorubicin in this experimental study.

Aims:
To investigate the potential roles of nebivolol and atenolol in the attenuation of doxorubicin (DXR)-induced cardiotoxicity in mice.

Materials and Methods:
A total of 42 Swiss-Albino male and female mice were used, which were divided into six equal groups: A negative control, a group 1 not received any agents, group 2 (DXR group) received a single dose of DXR 15 mg/kg, treated group 3 was pretreated with nebivolol 15 mg/kg plus DXR. Treated group 4 was pretreated with nebivolol 30 mg/kg plus DXR. Treated group 5 was pretreated with Atenolol 45 mg/kg plus DXR, and treated group 6 was pretreated with atenolol 90 mg/kg plus DXR. The duration of the study was 10 days. Inflammatory biomarkers including tumor necrosis factor-alpha (TNF-α), lactate dehydrogenase (LDH), malondialdehyde (MDA), and cardiac troponin (cTn-I) serum levels were measured. SPSS version 28.00 was used for data analysis.

Results:
TNF-α, LDH, MDA, and cTn-I serum levels were higher in the DXR-treated mice as compared to the control (P < 0.05). Nebivolol and atenolol produced a dose-dependent effect in the reduction of TNF-α, LDH, MDA, and cTn-I serum levels as compared to the DXR-treated mice (P < 0.05).

Conclusion:
Atenolol and nebivolol were effective agents in the mitigation of DXR-induced cardiotoxicity by their anti-inflammatory effects of both atenolol and nebivolol and antioxidant effects of nebivolol. Atenolol and nebivolol illustrated a dose-dependent effect in the attenuation of DXR-induced cardiotoxicity through inhibition of lipid peroxidation and cardiomyocyte injury.
Correlation of NF-kB Serum Level with the Expression Pattern of Microrna-221 in a Sample of Hcv-Exposed Iraqi Patients
Authors: Al-Salihy Shaimaa Rahem , Al-Shawk Refif , Al-Waysi Safaa Abdul-Karim , Rasheed Maarib Nazih 
Published: August 2023

Background:
Hepatitis C virus (HCV) has the ability to change cellular messenger RNA transcription and translation by stimulating the synthesis of cellular microRNAs (miRNAs) that impair immune response and facilitate viral reproduction. One of the most important members of the immune response against HCV is nuclear factor-kappa B (NF-κB), which is regulated by cellular miRNAs.

Aims:
we aimed to investigate the correlation of NF-κB serum level with circulatory miRNA-221 (miR-221) fold change in HCV-exposed individuals.

Materials and Methods:
Serum level of NF-κB in 88 samples (22 patients with persistent HCV infection, 22 individuals with spontaneous HCV virus clearance, 22 individuals treated with direct-acting antivirals (DAAs) drugs, and 22 uninfected apparently healthy blood donors as control) was measured by enzyme-linked immunosorbent assay. Reverse transcriptase–polymerase chain reaction was used to quantify the expression fold of circulatory miR-221.

Results:
The results showed that there was a significant decrease in the mean level of NF-κB at P < 0.000 among HCV-exposed patients (2.0058 ng/ml) as compared to the control group (2.9841 ng/ml). The mean fold change of miR-221 was significantly upregulated about six more times among HCV-exposed patients (mean = 6.3545) compared to the control group (mean = 1.1864). Furthermore, the mean ± standard deviation of miR-221 fold change in patients with persistent HCV infection was significantly higher compared to patients cured after DAA therapy (P = 0.048), there was a weak negative correlation (r = −0.246, P = 0.021) between NF-κB serum level and miR-221 folding level.

Conclusion:
HCV infection disrupts NF-κB activation, resulting in dysregulation of miR-221 that persists long after the virus has been cleared. Thus, quantification of serum NF-κB and miR-221in HCV-exposed patients could be used as noninvasive prognostic marker during long-term follow-up. Furthermore, a miRNAs profile analysis can help distinguish HCV-exposed from healthy individuals.
Morphometric Measurements of Carrying Angle of the Elbow among Sample of Iraqi Medical Students: An Observational, Cross-Sectional Study
Authors: Assi Mohammed Hussein 
Published: August 2023

Background:
The carrying angle (CA) is an acute angle occurring between the longitudinal axis of the upper arm and that of the extended and supinated forearm. CA allows swinging of the upper limb without hitting the pelvis. It appears to be larger in females than in males and also shows some variation to anthropometric parameters. Knowledge of CAs is valuable for orthopedic surgeons and biomedical engineers as well as for forensic specialists and anthropologists.

Aims:
The aim of the study is to evaluate the normal range of CA among Iraqi population.

Materials and Methods:
The CAs of the right and the left upper limbs was measured by a clinical goniometer in 200 medical students. Analysis for differences was performed according to gender, laterality, height, weight, and hip circumference (HC).

Results:
The mean right CA in men was 9° and in women was 10.75°, while the mean left CA was 8.76° in men and 10.51° in women. The mean CA in females is significantly larger than in males. The mean CA of the right elbow was greater than that of the left. The mean CA shows a positive correlation with the individual height, weight, and HC.

Conclusion:
The study fortifies the knowledge of the standard range of CA of the elbow in a study population of apparently healthy Iraqi medical students and tries to make a reference value to be used for orthopedic surgeons, biomedical engineers as well as for forensic specialists and anthropologists.
Evaluation of Protective Effect of Metformin in Rats with Experimental Osteoarthritis
Authors: Al-Buhadily Ali K. , Al-Uqabi Rabab Utba , Al-Gareeb Ali I. 
Published: August 2023

Objective:
The objective of this study is to evaluate metformin proposed protective effect against the development of osteoarthritis (OA) in rats.

Materials and Methods:
A total of 40 male Sprague–Dawley rats were included, divided into four groups: negative control (n = 10), positive control (OA induced by monoiodoacetate [MIA]) (n = 10), metformin 200mg/kg group (n = 10) preinduction of OA, and metformin 200 mg/kg group (n = 10) postinduction of OA. Serum C-telopeptide type II collagen (CTX-II), inflammatory biomarkers were evaluated for each group. For data analysis, SPSS version 26.00 was used.

Results:
Metformin-treated groups showed a significant reduction in inflammatory biomarkers and CTX-II serum levels compared with OA group (P < 0.05). Pretreatment with 200 mg/kg metformin imparted extra cartilage protective effect and further decreased inflammatory cytokines compared to posttreated (P < 0.05).

Conclusion:
Metformin produced a beneficial protective effect in experimental OA in rats. It attenuates the inflammatory reactions progression by preventing the release of pro-inflammatory cytokines in rats with experimental OA. Furthermore, metformin reduced cartilage degradation evidenced by lowering CTX-II serum levels experimental OA in rats.
Seroprevalence of Helicobacter pylori Infection in Tripoli, Libya
Authors: Atia Ahmed , Abuagela Manal , Abdulwahed Eman , Jerbi Rehab , Alwaseea Najia , Ahmed Fawzia , Alaqeli Eman , Ashur Abir Ben , El Magrahi Hamida , Mousa Arij 
Published: August 2023

Background:
Infection with Helicobacter pylori is typically contracted in early childhood and is associated with a variety of upper gastrointestinal disorders. There is still little local information available on infection epidemiology. This study was performed to determine the antibodies of seroprevalence of H. pylori in people, with their relation to age and gender.

Methods:
A retrospective epidemiologic survey was conducted in different polyclinics in Tripoli from January 2021 to December 2021 to determine the seroprevalence of H. pylori infection. A total of 707 participants (452 males and 255 females, with mean age of 39 ± 19.3 years) were included in this study. For the detection of H. pylori, enzyme-linked immunosorbent assay kits were utilized. In contrast, the absence of both antibodies (IgG and IgA) resulted in the designation of an H. pylori-negative status. Anti-H pylori immunoglobulin (Ig) G/IgA ≥30 enzyme immune units were classified as H. pylori positive. Chi-square test was used to analyze the obtained data.

Results:
The overall positive seropositive samples among the study participants were 122 (17.2%). The seropositivity was high 42 (34.4%) among the age group 30 <40 years, compared with the other age groups. There was no significant difference between male and female cases regarding the seropositive samples.

Conclusion:
Seroprevalence of H. pylori infection shows a drop comparing to previously local reports. Nationwide epidemiological research is necessary for determining the seroprevalence of H. pylori in Libya.
Molecular and Genetic Study for Detection of Helicobacter pylori Virulence Genes among Patients with Diffuse Large B-Cell Lymphoma
Authors: Alhasnawi Eman Abid Fahad , Bakir Wasan Abdulelah 
Published: August 2023

Background:
The bacteria Helicobacter pylori (Hp) has supposed to confirm an oncogenic consequence with the evolution of malignancy events in stomach, effectiveness of Hp consider a top risk factor of gastric-diffuse large B-cell lymphoma (DLBCL).

Aims:
the aim of this study was to observe the correlation between virulence factors, especially cytotoxin association gene A (CagA) and the progress of gastric DLBCL.

Materials and Methods:
Biopsy samples (50) involved in this study (28 were men, and 22 women, with a mean age up to 57.64 years), among gastric-DLBCL patients, with (25) control (were 14 men and 11 women) without DLBCL, tested at Medical City Teaching Hospital and Teaching Laboratories, study conducted from January 1st to September 30, 2022. Diagnosis was by molecular methods included DNA extraction for Hp by STR-Format kit (BIORON Diagnostics GmbHm In den Rauhweiden 20,67354 Germany), and “real-time polymerase chain reaction” methods using the (ABI PRISM 7700) Sequence Detection System, also applied the primers and probes, for Hp-CagA.

Results:
The mean of age was 55.7 ± 2 in DLBCL, while in control were 61.82 + 6, CagA +ve 66.66 + 2. In gastric DLBCL, the red blood cell count, white blood cell count, platelets count, and hemoglobin were all decline in DLBCL, not in the control group, lactate dehydrogenase levels in gastric DLBCL patients were rise (322 U/L), while less in control, while albumin (322g/dl) was less in gastric DLBCL patients. Hp 16S rRNA was detected relating to CagA variety, 66% (33/50) were CagA positive with highly significant in 23 patients with DLBCL (P = 0.004), and 10 in control patients. CagA gene expression was highly expression in gastric DLBCL patients with range up to (+), 8 (++), and 12 (+++), while in the control group was 5 (+), 2 (++), and 3 (+++), respectively.

Conclusions:
This present study fixed high frequency of CagA gene in gastric DLBCL patients. Moreover, confirmed this gene is significantly associated with gastric DLBCL in patients with Hp. Moreover, genotype EPIYA-ABC motif is related with the high risk of gastric DLBCL.
Research on Ephemeroptera (Insecta) fauna of Aydın and Denizli (Türkiye) provinces
Authors: AYDINLI Caner , ERTORUN Nesil 
Published: August 2023

Although studies on the order Ephemeroptera are at a sufficient level in many of the provinces in the Aegean region, there is no comprehensive study on the provinces of Aydın and Denizli. Until now, four species from Aydın and two species from Denizli province have been reported from the Ephemeroptera order. The research being done in these provinces, which are the study regions, aims to fill in the gaps in the Aegean Area and provide more precise information about the national Ephemeroptera fauna.
With the aid of sieves and water scoops, nymphs were gathered from the habitats of each locality's various biological characteristics during the field experiments, which were conducted in 25 different locations throughout two provinces. Thirteen species were recognized after examination of the 1177 collected specimens.
In the study, five of the species identified from Aydın province and 12 of the species identified from Denizli province were recorded for the first time from the related provinces within the research area.
Using drug information to bridge basic science with pharmacy practice
Authors: Nguyen Cambrey 
Published: August 2023

Background: Drug Information (DI) skills are essential to pharmacists and encompass information retrieval along with literature evaluation on drug characteristics, including foundational sciences. A novel approach was implemented using DI focused learning opportunities to educate first year learners about clinical relevance and integration of basic science concepts into pharmacist knowledge.
Methods: A lecture introduced the integration by mapping sections of a drug’s prescribing information to all courses in the University of Kansas School of Pharmacy curriculum. An innovative activity required students to use the knowledge obtained from concurrent P1 courses to determine the cause of death of a fictional patient. Other activities included answering drug availability questions on the clinical development process and presenting a research article. Assessment of learning was based on student performance.
Results: From 2019 to 2021, the proportion of students who determined the cause of death ranged from 59-67%, and the mean scores for the drug development assignments were 94-95%. The median score was 8/10 for the rubric item discussing the relevance of the research article to basic science and/or pharmacy practice, and total scores for the presentation ranged from 80-98%.
Conclusion: Based on the results, students demonstrated their understanding of the relationship between basic science and pharmacy practice.
Pelatihan Literasi dan Numerasi Peserta Didik SD Negeri Kragilan 2
Authors: Setyaputri Dine Vita Ayu , Fadilla Isnaini Nur Ilma , Nurpratiwiningsih Laelia , Santika Anis 
Published: August 2023

Literasi dan numerasi merupakan hal yang penting bagi anak sekolah dasar dan merupakan salah satu program dalam Program Kampus Mengajar. Program ini dilaksanakan dari beberapa mahasiswa yang terpilih. Tujuan dari kegiatan ini adalah untuk mengenalkan dan mengipmlementasikan bentuk literasi dan numerasi dalam kegiatan pembelajaran di sekolah dasar. Metode yang digunakan melalui observasi, dokumentasi dan ceramah. Pelatihan dilakukan dengan menyampaikan penjelasan terkait dengan jenis literasi, penerapan numerasi dalam kehidupan sehari dan menerapkan literasi dan numerasi dalam pembelajaran. Sasaran dalam pelaksanaan kegiatan ini adalah peserta didik dari kelas I-VI di SD Negeri Kragilan 2. Hasil kegiatan dapat terlihat bahwa proses pengenalan dan implementasi literasi dan numerasi di SD Negeri Kragilan 2 dapat berjalan dengan baik. Hal ini terlihat dari peserta didik dapat memahami dan dapat menerapkan dalam kehidupan sehari=hari. Selain itu, terdapat peningkatan bagi peserta didik dapat membaca dan berhitung dengan lancar.
Pelatihan Tari Kreasi sebagai Bentuk Apresiasi Seni Tari
Authors: Adawiyah Aenur Roiatul , Nurbaeti Rizki Umi 
Published: August 2023

Pendidikan seni ialah pendidikan yang memberikan wadah bagi anak untuk mengapresiasi diri sendiri dan lingkungan. Apresiasi akan timbul apabila pembelajaran dilaksanakan dengan baik dan benar oleh guru di sekolah. Artinya, guru dapat menghantarkan peserta didik dalam mencapai apresiasinya. Karena guru memiliki kapabilitas yang layak dalam pendidikan seni, terutama seni tari. Namun pada prakteknya, tujuan penggunaan tari belum sesuai dengan yang diharapkan. Tidak sedikit peserta didik yang mengerti apresiasi seni tari. Mereka juga kurang menganggap penting adanya tari. Sebagian mereka juga tidak tahu apa tujuan dan manfaat menari. Untuk itu, perlu dilaksanakan pelatihan seni tari kreasi kepada peserta didik, agar lebih paham makna dari apresiasi seni tari. Metode yang digunakan pada pelatihan tari kreasi yaitu persiapan, analisis desain pelatihan tari, pelaksanaan, serta evaluasi. Hasilnya, peserta didik mampu menghasilkan dan mempraktekkan tari kreasi yang telah kami latih. Peserta didik mampu menampilkan tari kreasi pada suatu acara pementasan seni yang dilaksanakan pada hari Jumat, tanggal 19 Agustus 2022. Tujuan pelatihan seni tari kreasi untuk memperkenalkan dan melestarikan karya seni, salah satunya yaitu seni tari di Indonesia. Serta dapat meningkatkan apresiasi seni pada seni tari.
Kata kunci— Apresiasi Tari, Tari, Tari Kreasi
Penyuluhan Swamedikasi Sediaan Obat Herbal sebagai Upaya Meningkatkan Pengetahuan Masyarakat Desa Sejahtera, Kecamatan Palolo, Kabupaten Sigi, Sulawesi Tengah
Authors: Tuldjanah Muthmainah , Budiawan Erick , Letana Trace Chintya 
Published: August 2023

Desa sejahtera merupakan desa yang memiliki tanah yang subur dan salah satu desa penghasil tumbuhan-tumbuhan yang bermanfaat seperti kopi, kemiri, coklat dll. Jika dilihat dari potensi tanah yang subur maka desa ini bisa dijadikan sebagai sentra penghasil tanaman obat herbal. Tujuan dilaksanakan kegiatan ini adalah agar masyarakat lebih mengenal tumbuhan yang dapat dijadikan obat. Selain itu untuk membantu masyarakat melakukan swamedikasi sediaan obat herbal di desa sejahtera kecamatan Palolo kabupaten Sigi. metode yang digunakan pada saat pelaksanaan pengabdian masyarakat berupa ceramah tentang swamedikasi sediaan obat herbal Untuk menilai tingkat pemahaman masyarakat terkait dengan materi yang disampaikan, pemateri membagikan kuisioner yang berisi instrument penilaian terkait keberhasilan kegiatan yang diisi oleh masyarakat yang mengikuti kegiatan ini Adapun hasil kegiatan penggabdian pada masyarakat ini dapat menambah pengetahuan masyarakat mengenai swamedikasi sediaan obat herbal hal ini sesuai dengan hasil rata-rata persentase quisioner yang dibagikan setelah penyuluhan yaitu 85,71%.
Pelatihan Berhitung Cepat dengan Metode Jarimatika bagi Siswa Sekolah Dasar Desa Cigadung
Authors: Rosiyana Melida , Umi Nurbaeti Rizki 
Published: August 2023

Metode jarimatika merupakan teknik berhitung yang menggunakan jari tangan yang mudah dan menyenangkan. Cara yang dapat dilakukan oleh guru dengan mengubah pemikiran anak terhadap penilaian buruk terhadap pelajaran matematika yaitu dengan memberikan suatu metode pembelajaran matematika yang mudah dimengerti dan menyenangkan. Siswa kelas III SD Negeri Cigadung 02 masih kesulitan dalam mengoperasikan perhitungan dalam matematika terutama dalam operasi berhitung. Metode pembelajaran yang digunakan siswa dalam berhitung matematika dengan menggunakan metode sempoa. Dengan adanya pelatihan ini metode yang digunakan berganti menjadi metode jarimatika, sehingga siswa-siswi mampu mengerjakan soal operasi berhitung dengan mudah dan cepat. Metode jarimatika digunakan untuk mempersingkat waktu mengerjakan tugas yang diberikan oleh guru dan dapat digunakan tanpa biaya. Tujuan dari kegiatan pengabdian ini adalah untuk memberikan pemahaman tentang metode jarimatika dan untuk mendukung dalam proses belajar berhitung yang menggunakan jari tangan sehingga memudahkan dalam kegiatan menghitung yang dapat diterapkan dalam kehidupan sehari-hari bagi siswa sekolah dasar. Untuk melaksanakan kegiatan ini digunakan dua metode pelatihan yaitu metode ceramah dan tanya jawab. Dalam kegiatan pelatihan jarimatika menggunakan tiga tahap yaitu tahapan persiapan, pelaksanaan dan evaluasi.
О возможности использования рыбных белковой и белково-минеральной добавок в технологии хлебобулочных изделий
Authors: Ключко Наталия Юрьевна , Позднякова Дарья Александровна , Ковалева Екатерина Дмитриевна 
Published: August 2023

В работе представлены данные опроса о предпочтениях респондентов в рационе питания. Проведены исследования по совершенствованию технологии хлебобулочных изделий – соломки пшеничной соленой и ржано-пшеничных хлебцев (краюшек) – путем их обогащения рыбными	белковой и белково-минеральной добавками. В первом случае задача решается за счет введения в состав теста ферментированного фарша трески, полученного путем выдер-живания измельченной мышечной ткани рыбы в воде при заданных параметрах (продолжительность ферментолиза 20 мин, температура воды 20±2 °С). Выпечен-ный готовый продукт представляет собой палочки округлой формы, слабо изо-гнутые, легко разламывающиеся, от светло-желтого до светло-коричневого цвета, хорошо пропеченные и без признаков непромеса, с приятным солоноватым вку-сом и запахом, с невыраженным ароматом рыбы. По результатам физико-химических исследований содержание белка увеличилось на 66 %, минеральных веществ – на 11 %. В другом случае используют белково-минеральную компози-цию, полученную путем выдерживания измельченной тушки трески в молочной сыворотке при технологических параметрах: время гидролиза 268 мин, темпера-тура 28 С. Готовый продукт был представлен в виде хлебцев (краюшек), изго-товленных путем выпечки готового теста с введением в рецептуру белково-минеральной композиции и солодового экстракта. Прямоугольные хлебцы темно-коричневого цвета, со вкусом солода, обладали приятным сладковатым арома-том, имели хорошо разрыхленную, равномерную структуру. Замечено, что введе-ние в состав рецептуры солодового экстракта обогащает продукт клетчаткой и белковыми веществами, улучшает органолептические характеристики готового продукта.