bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical stabilisation of distal femoral fractures in calves using a triple pin technique: Twenty‐five cases
Authors: Kılıç Engin , Yayla Sadık , Ermutlu Celal Şahin , Baran Vedat , Özba Burhan , Aydın Uğur , Yıldız Uğur 
Published: January 2023

AbstractBackgroundThe goal of this study was to develop a safe fixation technique for the effective treatment of supracondylar and distal diaphyseal femoral fractures in newborn calves.MethodsThis study included a total of 25 newborn calves diagnosed with supracondylar or distal diaphyseal femoral fractures based on anamnesis and clinical and radiographic examination findings. Operations were performed under intrathecal anaesthesia. During the operation, the fracture line was found, and fixation was achieved by placing two Steinmann and Schanz pins.ResultsNo abnormal findings were seen in the radiographs performed 28 days after surgery, and it was determined that a hard callus had started to form. It was observed that the patients who had lightly stepped on the ground for the first 3 days after the operation were able to walk without any problems on day 28.LimitationsAs this study involved neonatal calves aged 1–14 days, the operation could only be performed under spinal anaesthesia with no sedation. However, sedation is likely to be applied in addition to spinal anaesthesia in older calves.ConclusionIt was concluded that the triple pin technique can be safely used in the treatment of supracondylar and distal diaphyseal femoral fractures.
Pan‐targeted quantification of deep and comprehensive cancer serum proteome improves cancer detection
Authors: Zhang Jiayi , Hu Anqi , Chen Xuguang , Shen Fenglin , Zhang Lei , Lin Yuxiang , Shen Huali 
Published: January 2023

AbstractSerum/plasma proteome analysis can monitor physiological and pathological changes in the human population. In addition to the proteins secreted by tissues, the common blood proteins, including some inherently high‐abundance proteins, also play an important role in the process of the physiological process of organisms. Herein, we establish a Common Serum Protein Database (1090 proteins and 1727 peptides) and integrate it with the Cancer Serum Atlas (www.cancerserumatlas.com) we built before to construct the deep and comprehensive cancer serum protein atlas (DCCSP Atlas). This atlas contains over 2700 proteins with targeted mass spectrometry assays and spectra of corresponding unique peptides. We simultaneously targeted 539 proteins in 29 sera of two hardly distinguishable cancer types (breast and lung) and non‐tumor controls using the DCCSP Atlas and the pan‐targeted proteomic strategy. Areas under the receiver operating characteristic curve exceeded 0.96 for cancer detection and classification. The DCCSP Atlas will enable the pan‐targeting of common serum proteins and cancer‐secreted proteins to improve the sensitivity and specificity of proteomics‐based multi‐cancer detection and classification.
Characterization of hemp fiber fire reaction
Authors: Deborde Lily , Sonnier Rodolphe , Dumazert Loic , Lanos Christophe , Colson Valentin 
Published: January 2023

AbstractIntegrating bio‐resources in materials allows to reduce the environmental impact of the building industry. This study deals with fire‐retardant treatments, alternative to boric acid and ammonium salts solutions, applied to hemp fibers for thermal insulation application. The aim is to limit the energy, sanitary and environmental impacts of the treatment, while optimizing the technical performances. A laboratory protocol evaluates the flame‐retardant effect of the developed treatments. Treated fibers, including commercial treatments, are subjected to characterization tests: direct ignition small flame, thermal analysis (thermogravimetric analysis [TGA], differential thermal analysis [DTA]), pyrolysis‐combustion flow calorimeter and cone calorimeter. Some of the methods have been adapted to be applied to fibrous materials. The obtained results orientate the formulation of a treatment and highlight the complementarity of the analysis methods. Coupling the results, the ConeTools's predictive model leads to the estimation of the reaction to fire class according to the Euroclass. Euroclass C appears accessible with a tailored treatment.
Two-loop master integrals for a planar topology contributing to pp → $$ t\overline{t}j $$
Authors: Badger Simon , Becchetti Matteo , Chaubey Ekta , Marzucca Robin 
Published: January 2023

Abstract
We consider the case of a two-loop five-point pentagon-box integral configuration with one internal massive propagator that contributes to top-quark pair production in association with a jet at hadron colliders. We construct the system of differential equations for all the master integrals in a canonical form where the analytic form is reconstructed from numerical evaluations over finite fields. We find that the system can be represented as a sum of d-logarithmic forms using an alphabet of 71 letters. Using high precision boundary values obtained via the auxiliary mass flow method, a numerical solution to the master integrals is provided using generalised power series expansions.
Preconception factors associated with postnatal mental health and suicidality among first-time fathers: results from an Australian Longitudinal Study of Men’s Health
Authors: Giallo Rebecca , Wynter Karen , McMahon Grace , Seymour Monique , Fogarty Alison , Cooklin Amanda , Leach Liana , Francis Lauren M. , Duursma Elisabeth , Macdonald Jacqui A. 
Published: January 2023

Abstract
Purpose
Prospective evidence about men at risk of postnatal difficulties is rare–particularly for postpartum suicidal ideation. This study aimed to determine the extent to which first-time fathers reported depressive symptoms and suicidal ideation and behaviours in the first postnatal year, and to identify preconception risk factors for postnatal mental health difficulties.

Methods
Secondary analysis of data from The Ten to Men Study–Australia’s population-based prospective study of men’s health was conducted. Participants were 205 men who became first-time fathers in the 12 months prior to wave 2 (2015/16). Regression analyses were used to ascertain preconception (mental and physical health, lifestyle) and demographic factors associated with postnatal depressive symptoms.

Results
Postnatally, 8.3% of fathers reported moderate to severe depressive symptoms, 5% had suicidal thoughts, 3% had plans, and less than 1% had attempted suicide. Preconception depressive symptoms was the only factor significantly associated with postnatal depressive symptoms.

Conclusion
The transition into fatherhood is marked with significant psychological distress for some men. These results suggest that mental health screening and support in the preconception period is crucial to supporting the mental health of new fathers.
Compositional PLS biplot based on pivoting balances: an application to explore the association between 24-h movement behaviours and adiposity
Authors: Štefelová Nikola , Palarea-Albaladejo Javier , Hron Karel , Gába Aleš , Dygrýn Jan 
Published: January 2023

AbstractMovement behaviour data are compositional in nature, therefore the logratio methodology has been demonstrated appropriate for their statistical analysis. Compositional data can be mapped into the ordinary real space through new sets of variables (orthonormal logratio coordinates) representing balances between the original compositional parts. Geometric rotation between orthonormal logratio coordinates systems can be used to extract relevant information from any of them. We exploit this idea to introduce the concept of pivoting balances, which facilitates the construction and use of interpretable balances according to the purpose of the data analysis. Moreover, graphical representation through ternary diagrams has been ordinarily used to explore time-use compositions consisting of, or being amalgamated into, three parts. Data dimension reduction techniques can however serve well for visualisation and facilitate understanding in the case of larger compositions. We here develop suitable pivoting balance coordinates that in combination with an adapted formulation of compositional partial least squares regression biplots enable meaningful visualisation of more complex time-use patterns and their relationships with an outcome variable. The use and features of the proposed method are illustrated in a study examining the association between movement behaviours and adiposity from a sample of Czech school-aged girls. The results suggest that an adequate strategy for obesity prevention in this group would be to focus on achieving a positive balance of vigorous physical activity in combination with sleep against the other daily behaviours.
N-Acetylcysteine normalizes brain oxidative stress and neuroinflammation observed after protracted ethanol abstinence: a preclinical study in long-term ethanol-experienced male rats
Authors: Fernández-Rodríguez Sandra , Cano-Cebrián María José , Esposito-Zapero Claudia , Pérez Salvador , Guerri Consuelo , Zornoza Teodoro , Polache Ana 
Published: January 2023

Abstract
Rationale

Using a preclinical model based on the Alcohol Deprivation Effect (ADE), we have reported that N-Acetylcysteine (NAC) can prevent the relapse-like drinking behaviour in long-term ethanol-experienced male rats.

Objectives
To investigate if chronic ethanol intake and protracted abstinence affect several glutamate transporters and whether NAC, administered during the withdrawal period, could restore the ethanol-induced brain potential dysfunctions. Furthermore, the antioxidant and anti-inflammatory effects of NAC during abstinence in rats under the ADE paradigm were also explored.

Methods
The expression of GLT1, GLAST and xCT in nucleus accumbens (Nacc) and dorsal striatum (DS) of male Wistar was analysed after water and chronic ethanol intake. We used the model based on the ADE within another cohort of male Wistar rats. During the fourth abstinence period, rats were treated for 9 days with vehicle or NAC (60, 100 mg/kg; s.c.). The effects of NAC treatment on (i) glutamate transporters expression in the Nacc and DS, (ii) the oxidative status in the hippocampus (Hip) and amygdala (AMG) and (iii) some neuroinflammatory markers in prefrontal cortex (PFC) were tested.

Results
NAC chronic administration during protracted abstinence restored oxidative stress markers (GSSG and GGSH/GSH) in the Hip. Furthermore, NAC was able to normalize some neuroinflammation markers in PFC without normalizing the observed downregulation of GLT1 and GLAST in Nacc.

Conclusions
NAC restores brain oxidative stress and neuroinflammation that we previously observed after protracted ethanol abstinence in long-term ethanol-experienced male rats. This NAC effect could be a plausible mechanism for its anti-relapse effect. Also, brain oxidative stress and neuroinflammation could represent and identify plausible targets for searching new anti-relapse pharmacotherapies.
Host-associated Intraspecific Phenotypic Variation in the Saprobic Fungus Phlebiopsis gigantea
Authors: Kļaviņa Dārta , Lione Guglielmo , Kenigsvalde Kristīne , Pellicciaro Martina , Muižnieks Indriķis , Silbauma Lauma , Jansons Jurģis , Gaitnieks Tālis , Gonthier Paolo 
Published: January 2023

Abstract
Whether intraspecific phenotypic variation in saprobic fungi may be driven by the host of origin has received little attention. We addressed this issue by testing hypotheses using the model system Phlebiopsis gigantea, a wood destroying fungus associated with Picea abies and Pinus sylvestris, among others, and widely employed in practical forestry as a biological control agent. By examining approximately 60 sympatric P. gigantea isolates from both P. abies and P. sylvestris, we showed that the former grew in vitro significantly (P < 0.05) slower than the latter (average 5.56 mm/day vs. 6.84) while producing 1.8-fold significantly higher number of mitospores. An overall significant trade-off between these two phenotypic traits was detected, in particular for isolates originating from P. abies. Comparative inoculation experiments of a subsample of isolates and the assessment of mycelial growth in logs of both hosts allowed to reject the hypothesis that isolates are equally fit in terms of growth rate in wood of both hosts regardless of the host of origin. Tree models revealed that the growth rate of isolates was associated not only with the wood species in which the isolates were inoculated (P < 0.001), P. sylvestris being more rapidly colonized than P. abies, but also with the host of origin of isolates (P < 0.001). Results showed that P. gigantea isolates originating from different hosts differ phenotypically in terms of some key phenotypic traits demonstrating that a host-driven intraspecific phenotypic variation may occur in saprobic fungi.
Dietary intakes of iron, folate, and vitamin B12 during pregnancy and correlation with maternal hemoglobin and fetal growth: findings from the ROLO longitudinal birth cohort study
Authors: Rooney David J. , Conway Marie , O’Keeffe Linda M. , McDonnell Ciara M. , Bartels Helena C. , Yelverton Cara , Segurado Ricardo , Mehegan John , McAuliffe Fionnuala M. 
Published: January 2023

Abstract
Purpose
Dietary micronutrient intakes of iron, folate and vitamin B12 are known to influence hemoglobin. Low maternal hemoglobin (maternal anemia) has been linked to low birthweight and other adverse health outcomes in the fetus and infant. Our primary aim was to explore relationships between maternal dietary micronutrient intakes, maternal full blood count (FBC) parameters and fetal abdominal circumference (AC) and estimated fetal weight (EFW) growth trajectories. Secondarily, we aimed to assess relationships between maternal dietary micronutrient intakes, maternal hemoglobin values and placental weight and birthweight.

Methods
Mother–child pairs (n = 759) recruited for the ROLO study were included in this analysis. Maternal dietary micronutrient intakes were calculated from food diaries completed during each trimester of pregnancy. FBC samples were collected at 13- and 28-weeks’ gestation. Fetal ultrasound measurements were recorded at 20- and 34-weeks’ gestation. Growth trajectories for AC and EFW were estimated using latent class trajectory mixture models.

Results
Dietary intakes of iron and folate were deficient for all trimesters. Mean maternal hemoglobin levels were replete at 13- and 28-weeks’ gestation. Dietary iron, folate and vitamin B12 intakes showed no associations with fetal growth trajectories, placental weight or birthweight. Lower maternal hemoglobin concentrations at 28 weeks’ gestation were associated with faster rates of fetal growth and larger placental weights and birthweights.

Conclusion
The negative association between maternal hemoglobin at 28 weeks’ gestation and accelerated fetal and placental growth may be due to greater consumption of maternal iron and hemoglobin by fetuses’ on faster growth trajectories in addition to placental biochemical responses to lower oxygen states.
Cholelithiasis is an additional pre-pregnancy clinical risk factor for preeclampsia
Authors: Arbuzova Svitlana , Nikolenko Margaryta , Wright David , Cuckle Howard 
Published: January 2023

Abstract
Purpose
To investigate additional potential clinical risk factors for preeclampsia.

Methods
This is a nested case–control study of preeclampsia and unaffected pregnancies. Cases were either from a prenatal screening database or from a national network of clinicians, and controls were from the same prenatal source. Preeclampsia was defined by international criteria which were endorsed by the Ukraine Ministry of Health. Questionnaires were used to record a range of pregnancy related factors, personal history of health conditions and family history, followed by a telephone interview to collect more details.

Results
There were 103 cases, 56 from the prenatal database and 47 from the clinicians, and 480 controls from the database. The two types of case did not differ in terms of age, weight, BMI or parity. Known risk factors were more common in cases than controls. In addition there was a 17-fold higher prevalence of cholelithiasis in cases compared with controls (29.1% versus 1.7%), a highly statistically significant difference (P < 0.0001). There was also an 8.8-fold increase among the mothers of cases and controls (P < 0.0001), and if either the patient or her mother had the disease the increase was 6.4-fold (P < 0.0001). Including the father or sibling did not increase the relative risk.

Conclusion
Cholelithiasis is a clinical risk factor for preeclampsia which has not previously been reported. If confirmed by additional studies it may have utility in routine prenatal screening and provide insight into the pathogenesis of preeclampsia.
Genomic and metabolic profiling of two tomato contrasting cultivars for tolerance to Tuta absoluta
Authors: D’Esposito Daniela , Guadagno Anna , Amoroso Ciro Gianmaria , Cascone Pasquale , Cencetti Gabriele , Michelozzi Marco , Guerrieri Emilio , Ercolano Maria Raffaella 
Published: January 2023

Abstract
Main conclusion
Dissimilar patterns of variants affecting genes involved in response to herbivory, including those leading to difference in VOC production, were identified in tomato lines with contrasting response to Tuta absoluta.

Abstract
Tuta absoluta is one of the most destructive insect pest affecting tomato production, causing important yield losses both in open field and greenhouse. The selection of tolerant varieties to T. absoluta is one of the sustainable approaches to control this invasive leafminer. In this study, the genomic diversity of two tomato varieties, one tolerant and the other susceptible to T. absoluta infestation was explored, allowing us to identify chromosome regions with highly dissimilar pattern. Genes affected by potential functional variants were involved in several processes, including response to herbivory and secondary metabolism. A metabolic analysis for volatile organic compounds (VOCs) was also performed, highlighting a difference in several classes of chemicals in the two genotypes. Taken together, these findings can aid tomato breeding programs aiming to develop tolerant plants to T. absoluta.
Should individual timeline and serial CT/MRI panels of all patients be presented in acute brain insult cohorts? A pilot study of 45 patients with decompressive craniectomy after aneurysmal subarachnoid hemorrhage
Authors: Autio Anniina H. , Paavola Juho , Tervonen Joona , Lång Maarit , Huuskonen Terhi J. , Huttunen Jukka , Kärkkäinen Virve , von Und Zu Fraunberg Mikael , Lindgren Antti E. , Koivisto Timo , Kurola Jouni , Jääskeläinen Juha E. , Kämäräinen Olli-Pekka 
Published: January 2023

Abstract
Purpose

Our review of acute brain insult articles indicated that the patients’ individual (i) timeline panels with the defined time points since the emergency call and (ii) serial brain CT/MRI slice panels through the neurointensive care until death or final brain tissue outcome at 12 months or later are not presented.

Methods
We retrospectively constructed such panels for the 45 aneurysmal subarachnoid hemorrhage (aSAH) patients with a secondary decompressive craniectomy (DC) after the acute admission to neurointensive care at Kuopio University Hospital (KUH) from a defined population from 2005 to 2018. The patients were indicated by numbers (1.–45.) in the pseudonymized panels, tables, results, and discussion. The timelines contained up to ten defined time points on a logarithmic time axis until death ($$n=25$$

n
=
25

; 56%) or 3 years ($$n=20$$

n
=
20

; 44%). The brain CT/MRI panels contained a representative slice from the following time points: SAH diagnosis, after aneurysm closure, after DC, at about 12 months (20 survivors).

Results
The timelines indicated re-bleeds and allowed to compare the times elapsed between any two time points, in terms of workflow swiftness. The serial CT/MRI slices illustrated the presence and course of intracerebral hemorrhage (ICH), perihematomal edema, intraventricular hemorrhage (IVH), hydrocephalus, delayed brain injury, and, in the 20 (44%) survivors, the brain tissue outcome.

Conclusions
The pseudonymized timeline panels and serial brain imaging panels, indicating the patients by numbers, allowed the presentation and comparison of individual clinical courses. An obvious application would be the quality control in acute or elective medicine for timely and equal access to clinical care.
Safety of upadacitinib in Latin American patients with rheumatoid arthritis: an integrated safety analysis of the SELECT phase 3 clinical program
Authors: Kakehasi Adriana Maria , Radominski Sebastião Cezar , Baravalle Marcos Daniel , Palazuelos Fedra Consuelo Irazoque , Garcia-Garcia Conrado , Arruda Maysa Silva , Curi Marco , Liu John , Qiao Meihua , Velez-Sanchez Patricia , Vargas Juan Ignacio 
Published: January 2023

AbstractIntroduction/objectivesRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by ongoing inflammation and degradation of synovial joints. The oral JAK inhibitor, upadacitinib, is approved for RA. We conducted an integrated safety analysis of upadacitinib 15 mg once daily (QD) in patients from Latin America (LATAM) versus the rest of the world (RoW).MethodsTreatment-emergent adverse events (AEs) and laboratory data from six phase 3, randomized controlled trials, adjusted for upadacitinib 15 mg QD use in RA, were analyzed.ResultsOverall, 3209 patients received upadacitinib 15 mg QD for 7024 patient-years (PY). LATAM patients (n = 725) had a mean upadacitinib exposure of 1518 PY. Baseline characteristics were generally similar between LATAM and RoW populations. AE rates (including serious/opportunistic infections, tuberculosis, and herpes zoster) and deaths were comparable between populations. LATAM patients had lower serious AE rates per 100 PY (9.4 vs 14.0 E/100 PY) and discontinuation-related AEs (3.9 vs 6.0 E/100 PY) versus RoW. Rates of cardiovascular events were low (≤ 0.5 E/100 PY) and similar between populations. Malignancies, excluding non-melanoma skin cancer, were less common in the LATAM population versus RoW (0.2 vs 1.0 E/100 PY). Laboratory abnormalities were similar between populations, with decreases in hemoglobin, lymphocyte, and neutrophil counts, and elevations in liver enzymes and creatine phosphokinase. Mean change from baseline in low- and high-density lipoprotein cholesterol was generally comparable between LATAM and RoW populations.ConclusionUpadacitinib 15 mg QD demonstrated a consistent safety profile across LATAM and RoW patient populations, with no new safety risks observed.Trial registration numbersSELECT-EARLY, NCT02706873; SELECT-NEXT, NCT02675426; SELECT-COMPARE, NCT02629159; SELECT-MONOTHERAPY, NCT02706951; SELECT-BEYOND, NCT02706847; SELECT-CHOICE, NCT03086343.Key Points• This study assessed the safety of upadacitinib 15 mg in patients with rheumatoid arthritis from Latin America compared with patients from the rest of the world participating in the SELECT phase 3 program.• Safety was generally similar between the two groups, including serious and opportunistic infections, tuberculosis, herpes zoster, and cardiovascular events. Malignancy, major adverse cardiovascular events, and venous thromboembolic events were infrequent in the Latin American patients.• Consistent with the known safety profile of upadacitinib, serious infections, herpes zoster, and laboratory abnormalities were the most common safety events in the Latin American population.