bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of micro-metastasis using cytokeratins (AE1/AE3) in haematoxylin & eosin-stained N0 lymph nodes of oral squamous cell carcinoma
Authors: Sinha Gargi Mila , Hegde Veda 
Published: May 2023

Background & objectives:
Oral squamous cell carcinoma (OSCC) is one of the most common malignancies affecting the head-and-neck region, regional lymph nodes being an important prognostication factor dictating the survival rate. Despite an array of modalities used, clinically, radiographically and routine histopathologically, the detection of micro-metastasis (2-3 mm tumour cell deposits) in the lymph nodes often escapes identification. The presence of few of these tumour epithelial cells in the lymph nodes drastically increases mortality and alters treatment plan. Hence, the identification of these cells is of major prognostic significance for a patient. Thus, the present study was aimed to evaluate and detect the efficacy of the immunohistochemical (IHC) marker [cytokeratin (CK) AE1/AE3] over routine Hematoxylin & eosin (H & E) staining in detecting micro-metastasis in the lymph nodes of OSCC cases.

Methods:
Hundred H & E-stained N0 lymph nodes of OSCC cases treated with radical neck dissection were subjected to IHC with marker AE1/AE3 antibody cocktail for detecting micro-metastasis.

Results:
The IHC marker CK cocktail (AE1/AE3) did not demonstrate any positive reactivity for the target antigen in all the 100 H & E stained lymph node sections evaluated in the present study.

Interpretation & conclusions:
This study was undertaken to check the efficacy of IHC (CK cocktail AE1/AE3) in the detection of micro-metastasis in lymph nodes that are found to be negative in routine H&E stained sections. The findings of this study suggest that the IHC marker AE1/AE3 did not prove to be useful to detect micro-metastasis in this study population.
The Methotrexate Story: How did a Cancer Chemotherapeutic Agent Become a Disease-modifying Antirheumatic Drug
Authors: Malaviya Anand N. , Sareen Astha 
Published: May 2023

Abstract
Weekly mini-pulse of low-dose methotrexate (LD-MTX) is presently the first-line conventional synthetic disease-modifying antirheumatic drug for the treatment of rheumatoid arthritis (RA) and several other systemic immunoinflammatory rheumatic diseases (SIRDs). Yet, most of the younger generation of rheumatologists around the world may be unaware of the interesting journey of MTX, from being an antifolate agent for use as cancer chemotherapy to becoming the mainstay of treatment for inflammatory arthritides and other SIRDs. This short essay narrates the journey of MTX from its precursor analog aminopterin to treat childhood leukemia, its name change from aminopterin to MTX, which became one of the major chemotherapeutic agents in oncology and then evolving as the mainstay of drug treatment for RA and other SIRDs. The seminal role of Gubner et al. from New York in 1953 in recognizing its steroid-sparing property in inflammatory diseases at doses much lower than that needed to treat cancer is highlighted.
Clinical and Serological Profile of Sjögren’s Syndrome Patients in a Tertiary Care Center in Kashmir, North India
Authors: Ahmad Mushtaq , Guroo Farooq Ahmad , Sofi Fayaz Ahmad , Naqati Shaariq Mehraj , Shah Tajamul Hussain 
Published: May 2023

Abstract

Background:
Sjögren’s syndrome (SS) is a chronic autoimmune illness characterized by lymphocyte infiltration and exocrine gland inflammation. SS has been considered a rare disorder in India, and data on its clinical manifestations and serology are lacking from North India.

Aim:
We aimed to study clinical manifestations, organ involvement, and autoantibodies in SS patients from Jammu and Kashmir.

Methods:
This was a single-center observational prospective study. A total of 50 patients satisfying the American-European Consensus Group criteria were included in the study. Data regarding subjective and objective evidence of disease were compiled. Extraglandular manifestations in the form of musculoskeletal, renal, pulmonary, and neurological were also recorded.

Results:
Of the 50 patients, 29 were primary SS and 21 were secondary SS. Female preponderance was observed with a female-to-male ratio of 24: 1. Xerostomia was the most common symptom present in all of the patients. The most common extraglandular involvement was musculoskeletal followed by renal and pulmonary.

Conclusions:
Early onset of the disease by a decade is a surprising observation in this study and rest of the Indian literature compared to western literature.
Recurrent Infections in an Infant
Authors: Agarwal Nagamani , Chaya K. A. , Megha P. , Subhash Anand 
Published: May 2023

Background:
Cyclic neutropenia (CyN) is a rare inherited neutrophil disease characterized by a periodic neutropenia with an absolute neutrophil count (ANC) dropping below 0.5 × 109/L every 3–4 weeks, followed by normalization over the next few days.

Clinical Description:
A 3-year-old boy presented with recurrent episodes of fever, respiratory tract infections, diarrhea, gingivitis, and oral and cutaneous ulcers from 11 months of age, requiring multiple hospitalizations. He was immunized for age, normal development, with an unremarkable family history. An underlying primary immunodeficiency disorder was suspected in view of recurrent multi-site infections since infancy.

Management:
The hemogram revealed a normal total leukocyte count with severe, neutropenia, lymphocytosis, normal platelet count and severe anemia. Purified protein derivative test and human immunodeficiency virus test were negative. The chest Xray showed right lower lobe consolidation. Blood culture was sterile. Bone marrow study, immunoglobulin profile, and lymphocyte subtyping were within the normal limits. The child was treated symptomatically with parenteral antibiotics and packed red blood cells transfusion. The ANC increased to 2592/mm3 but, again fell by 27 days after admission. Review of previous blood counts showed a fall and rise of ANC every 3–5 weeks. Clinical exome sequencing revealed a heterozygous mutation in the ELANE gene, a pathogenic variant c. 1A>G (p.Met1), confirming the diagnosis of CyN. The child improved with Granulocyte – colony stimulating factor (G-CSF).

Conclusion:
Diagnosis of CyN can be challenging as it needs a high index of suspicion and meticulous monitoring of blood counts. If suspected, they should be screened for ELANE mutations.
Efficacy of dexmedetomidine as an adjuvant with ropivacaine in USG guided erector spinae plane block for modified radical mastectomy surgery- prospective randomized double blind controlled study
Authors: Kumari Indira , Sharma Sandeep , Ola Sandeep Kumar , Boliwal Krishna , Choudhary Santosh , Yadav Vidhu 
Published: May 2023

Background and Aims:
Modified radical mastectomy (MRM) is associated with considerable acute postoperative pain and even chronic persistent pain. Erector spinae plane block (ESPB) is interfascial block for thoracic analgesia. This study was planned to evaluate efficacy of dexmedetomidine as adjuvant with ropivacaine in ESPB for postoperative analgesia in MRM surgery.

Materials and Methods:
In this prospective randomized double-blind controlled study, 60 American Society of Anesthesiologists Grade I and II female patients, aged 18–60 years scheduled for MRM surgery under general anesthesia were randomly allocated into Group R and RD to receive ultrasound (USG)-guided ESPB with 20 ml 0.375% ropivacaine and 1 μg/kg dexmedetomidine added to 20 ml 0.375% ropivacaine, respectively. Visual Analog Score (VAS) was recorded at 0, 2, 4, 6, 8, 10, 12, and 24 h postoperatively. Duration of analgesia together with total number and amount of analgesic drug required was recorded in first 24 h postoperatively. Patient's satisfaction score was recorded on 10-point scale. Chi-square test, t-test, and Wilcoxon signed-rank test were applied where deemed appropriate. P <0.05 was considered statistically significant.

Results:
VAS score was less in Group RD at all measured time points postoperatively. Duration of analgesia was prolonged in Group RD (683.00 ± 83.99 min vs. 620.63 ± 70.42 min). Total number and amount of intravenous diclofenac (rescue analgesic) was lower in Group RD (1.13 ± 0.57 vs. 1.46 ± 0.57, 85.00 ± 42.85 vs. 110.00 ± 42.85). Patients in group RD were better satisfied with their anesthesia experience (8 [8–9] vs. 8 [7–8], P = 0.00194). Group RD demonstrated a lower heart rate, systolic blood pressure, diastolic blood pressure, and mean blood pressure intraoperatively.

Conclusion:
Dexmedetomidine as an adjuvant to ropivacaine in USG-guided ESPB for MRM surgery leads to lower postoperative pain scores, prolongs postoperative analgesia, reduces postoperative rescue analgesics requirements, and provides better hemodynamic stability and good patient satisfaction.
TVET SI: Towards Sustainable Vocational Education and Training: Thinking beyond the formal
Authors: McGrath Simon , Russon Jo-Anna 
Published: May 2023

Mainstream vocational education and training (VET) has been complicit in unsustainable practices due to its longstanding relationship with productivism, extractivism and colonialism. However, it is beginning to address the need to balance its dominant focus on skills for employability with a growing awareness of the imperative to promote environmental sustainability, in terms of skills for sustainable production. There is also a sense that vocational institutions must also be sustainable in the wider sense of viability, durability, etc. While these positive steps are welcome, careful analysis is needed regarding how far recent initiatives are limited both by institutional capacities and wider disenabling environments, and how far they are meaningful steps towards sustainable VET for just transitions. Moreover, the current debate is also limited in its overwhelming focus on formal spaces of learning and work. Yet, most vocational learning and work sits outside this formal realm. We contribute to this debate by exploring four case studies of complex skills ecosystems with varying levels of (in)formality taken from both rural and urban settings in Uganda and South Africa. We consider how the dynamics of each ecosystem generate complex mixes of sustainability and employability concerns. We suggest that, in cases like the more formalised ones presented here, there is a possibility to look at the development of centres of skills formation excellence grounded in sector and place but that this also requires thinking about bigger challenges of just transitions. More radically, by highlighting the contexts of less formalised skills ecosystems in two other cases, we point towards new ways of thinking about supporting such ecosystems’ work on sustainable livelihoods in ways that enhance their durability. Although context always matters, we suggest that our arguments are pertinent beyond the countries or region of this research and have international salience.
Keywords: vocational education and training, Africa, green skills, sustainable development, skills for sustainability
TVET SI: Evaluating Boundary Crossing Social Learning in Vocational Education and Training: A value creation approach
Authors: Lotz-Sisitka Heila , Sisitka Lawrence , Chakona Gamucharai , Matiwane Mandilive , Matambo Chamu 
Published: May 2023

This article focuses on the development and application of an evaluation model and approach for evaluating boundary crossing social learning in a Vocational Education and Training (VET) learning network in South Africa, with an emphasis on a Training of Trainers (ToT) course that helped to catalyse and strengthen this learning network via two iterations of the course over an eight-year period. The article shares how we adapted the value creation framework (VCF) of Wenger, Traynor and De Laat (2011; Wenger & Wenger-Traynor, 2020) in the evaluation of a VET Training of Trainers (ToT) programme and learning network that focussed on the uptake and circulation of rainwater harvesting and conservation (RWH&C) knowledge in a particular formal and informal VET context in the Eastern Cape, South Africa, where smallholder farmers were struggling to find water for producing food. The evaluated ToT course was catalytic in establishing a boundary crossing social learning network approach in a VET context that linked formal and informal VET (Lotz-Sisitka et al., 2016; Lotz-Sisitka et al., 2022; Pesanayi, 2019); hence we found it important to develop adequate tools for its evaluation. The focus of this article is to share how we developed an evaluation approach to this work. We share insights on the indicators developed for diff erent types of value created, and also insights gained into the use of this evaluation approach in a boundary crossing VET social learning project that took a ToT course as focus. In short, evaluation findings show that the boundary crossing ToT course off ers strong immediate, potential and applied value that can lead to realised and reframed value, especially if supported by ongoing learning network activities that follow the initial engagement in the boundary crossing ToT course. Th is leads, over time, to transformative value which is important in achieving the overall objective of such social learning, namely making knowledge more co-engaging, accessible and useful in the context where improved food security via better use of rainwater harvesting and conservation amongst smallholder farmers and household food producers is a necessary form of sustainable development. Orientation value, and enabling value were found to be vital for the emergence of other kinds of value. The evaluation model also allows for the lifting out of strategic value which points to wider uptake potential. All this creates the possibility for indicator development that can help inform iterative development of boundary crossing VET courses used to stimulate the co-construction of learning networks and ongoing social learning for sustainable development.
Keywords: Vocational Education and Training, evaluation, social learning, value creation framework
ANAIS DO III ENCONTRO NORTE MINEIRO DE SERVIÇO SOCIAL - ENMSS
Authors: Revista Serviço Social em Perspectiva  
Published: May 2023

Anais do III Encontro Norte Mineiro de Serviço Social - III ENMSS.
Textos apresentados nas Comunicações Orais e nas Mesas Coordenadas Temáticas aprovadas para o encontro que ocorreu entre os dias 28 a 30 de abril de 2022, na Universidade Estadual de Montes Claros - UNIMONTES, MONTES CLAROS, MG.
PENINGKATAN EFISIENSI ENERGI PADA UNIT SPAM PADALARANG PERUMDA AIR MINUM TIRTA RAHARJA KABUPATEN BANDUNG
Authors: Suatmadji Galih Priyonggo , Masduqi Ali , Pandin Gabriel Novianus Rumambo 
Published: May 2023

Pelayanan air minum Kecamatan Padalarang Kabupaten Bandung diselenggarakan oleh Perumda Air Minum Tirta Raharja menggunakan kombinasi sistem perpompaan. Penggunaan sistem perpompaan mengakibatkan biaya energi di Sistem Penyediaan Air Minum Padalarang Perumda Air Minum Tirta Raharja Kabupaten bandung (839 Rp/m3) lebih tinggi dibandingkan rata-rata nasional (345,77 Rp/m3). Lokasi penelitian di sistem distribusi Padalarang dipilih karena operasional pompa pada sistem ini berjalan selama 24 jam langsung melayani pelanggan. Pompa eksisting beroperasi mengikuti fluktuasi debit penggunaan pelanggan yang mengakibatkan penggunaan energi menjadi tidak efisiensi. Penelitian ini menganalisis alternatif peningkatan efisiensi energi pada sistem perpompaan Pedalarang melalui skema pemasangan Variable Speed Drive (VSD) pada pompa sumur dalam dan optimalisasi jaringan produksi dan disitribusi. Pelaksanaan penilitian dilakukan dengan mengambil beberapa data diantaranya data aliran debit pompa sumur dalam, debit pompa distribusi, tekanan pada pipa transmisi, tekanan pada pipa distribusi, konsumsi energi pompa sumur dalam, tagihan rekening listrik SPAM Padalarang dan dimensi jaringan pipa transmisi unit Produksi dan pipa distribusi unit distribusi SPAM Padalarang guna mengevaluasi kebutuhan volume reservoir untuk mencukupi kebutuhan volume air pelayanan distribusi dan penentuan elevasi eleated reservoir guna mencukupi tekanan minimum pada titik kritis pelayanan. Peluang penghematan energi untuk mendapatkan sistem yang lebih efisien sangat terbuka untuk diterapkan. Skema Optimalisasi Jaringan Unit Produksi dan Distribusi berupa perencanaan elevated reservoir dan pemasangan Variable Speed Drive (VSD) pada pom dapat mengurangi waktu kerja pompa distribusi dan beban kerja pompa yang lebih ringan, dikarenakan perputaran motor pompa yang bervariasi karena frekuensinya diatur oleh VSD. Hal ini berpengaruh pada penurunan tagihan energi listrik dari semula Rp. 49.395.413,00/bulan menjadi Rp 32.242.587,00/bulan. Penurunan pemakaian energi listrik di Sistem Distribusi SPAM Padalarang akan mengurangi tagihan listrik sebesar 34,72%. Penurunan tagihan tersebut membuat Perumda Air Minum Tirta Raharja akan menghemat Rp 17.152.825 setiap bulannya
Calidad de vida en pacientes con esclerosis sistémica en confinamiento por pandemia de COVID-19 en Argentina
Authors: Izaguirre Pía , Tamborenea María Natalia , Brigante Alejandro , Salvatierra Gabriela , Sabelli Mirtha , Pendon Gisela , Caro Fabián , Molina Josefina , Nitsche Alejandro , Yucra Demelza , Morbiducci Julieta , Dalpiaz Marina , Pucci Paula , Crespo María Elena , Montoya Sandra Fabiana 
Published: May 2023

Introducción: los pacientes con enfermedades reumáticas tienen una calidad de vida significativamente deteriorada. La pandemia por COVID-19 tuvo un notable impacto sobre la población y los sistemas de salud de todo el mundo.
Objetivos: en este trabajo nos proponemos conocer el impacto de la pandemia en la calidad de vida de los pacientes con esclerosis sistémica (ES) y cómo fue el acceso a la atención médica.
Materiales y métodos: mediante encuestas anónimas y digitales a pacientes durante julio y agosto de 2020 se evaluó la calidad de vida utilizando el cuestionario de calidad de vida de la esclerosis sistémica (SScQoL). Además, se realizaron preguntas para evaluar el acceso al sistema de salud durante ese período.
Resultados: se encuestaron 300 pacientes con ES. La mediana de afectación de la calidad de vida según el cuestionario utilizado fue de 17 (9,25-22) y fue el dolor el dominio más afectado. El 29,33% no hizo los controles médicos. El 74,33% refirió haber tenido estudios médicos pendientes al inicio de la cuarentena y solo el 25% pudo realizarlos.
Conclusiones: los pacientes con ES presentaron compromiso de la calidad de vida durante la pandemia y mostraron dificultades en el acceso al sistema de salud.
El fútbol profesional como plataforma para la inclusión social: una experiencia de intervención en Ciudad Juárez, México (Professional football as a platform for social inclusion: an experience of intervention in Ciudad Juárez, Mexico)
Authors: Buch Sánchez Esteban , Bores-García Daniel 
Published: May 2023

En el presente artículo se presenta una experiencia de intervención a través del deporte, llevada a cabo con jugadores del FC Juárez (Ciudad Juárez, México), orientada a ayudar a los deportistas a conciliar el ámbito deportivo y académico-familiar, a fomentar su crecimiento personal a través de la educación en valores y a promover itinerarios de intervención para dar apoyo individualizado a estos jugadores como parte del proceso de desarrollo personal y académico en el contexto de la intervención social. Esta intervención, basada en una perspectiva sistémica del binomio jugador-familia, incluyó actividades enfocadas en el jugador, en su familia y en el cuerpo técnico. El artículo concluye con la exposición de los principales resultados de la intervención en el ámbito deportivo, académico y socio-comunitario.
Palabras clave: intervención social; fútbol; inclusión; educación; deporte.
Abstract. This article presents an experience of intervention through sport, carried out with FC Juárez players (Ciudad Juárez, México), aimed at helping athletes to reconcile the sporting and academic-family environment, to promote their personal growth through education in values and to promote intervention itineraries to provide individualised support to these players as part of the process of personal and academic development in the context of social intervention. This intervention, based on a systemic perspective of the player-family binomial, included activities focused on the player, his family and the coaching staff. The article concludes with the main results of the intervention in the sporting, academic and socio-community spheres.
Keywords: social intervention; football; inclusion; education; sport.
Symmetric Kernel-Based Approach for Elliptic Partial Differential Equation
Authors: Nengem Stephen Mkegh 
Published: May 2023

In this work, two globally supported and positive definite radial kernels: generalized inverse multiquadric and linear Laguerre Gaussian radial kernels were used to construct symmetric kernel-based interpolating scheme using Hermite-based symmetric approach for the solution problems involving Hermite's scattered data. Furthermore, two examples on elliptic partial differential equations to illustrate the viability of the symmetric formulation were effectively solved with comparable performance. Results were displayed inform of tables and graphs which present interesting sights for discussions and inference.

Received: 22 March 2023 | Revised: 9 May 2023 | Accepted: 23 May 2023

Conflicts of Interest
The author declares that he has no conflicts of interest to this work.
Implicaciones jurídicas y administrativas en la ejecución de los actos administrativos en los GADS de Guamote y Riobamba durante la emergencia sanitaria
Authors: Andino Peñafiel Javier Lenin Andino Peñafiel , Herrera Acosta Carlos Ernesto 
Published: May 2023

La actividad primordial del Estado, es la administración pública, hecho por medio del cual ejecuta de manera legal, sistemática, transparente, técnica y permanente los actos administrativos, mismos que deben ser planificados, controlados, evaluados y sobre todo apegados a derecho con el fin de proporcionar a los mandantes bienes y servicios de oprima calidad para el bienestar colectivo; en este, la investigación “IMPLICACIONES JURÍDICAS Y ADMINISTRATIVAS EN LA EJECUCIÓN DE LOS ACTOS ADMINISTRATIVOS EN LOS GADs DE GUAMOTE Y RIOBAMBA DURANTE LA EMERGENCIA SANITARIA”, tiene como propósito determinar la legalidad de los actos administrativos ejecutados durante la emergencia sanitaria y señalar sus implicaciones jurídicas y administrativas. La población involucrada está constituida por, Jueces de Garantías Constitucionales; Abogados especialistas en derecho administrativo y funcionarios de los Gobiernos Autónomos Municipales; los resultados de la investigación indican que durante la emergencia sanitaria a consecuencia del Covid 19, se cometieron varios actos administrativos fraudulentos en los GADS municipales, razón por la cual se concluye señalando, qué en el Ecuador actualmente nos solo se vive una ola de corrupción y violencia, sino de inseguridad jurídica que atenta al Estado Constitucional de Derechos y Justicia; a la convivencia pacífica y armónica; y, al buen vivir de los ecuatorianos.