bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reactive arthritis following COVID-19 current evidence, diagnosis, and management strategies
Authors: Migliorini Filippo , Bell Andreas , Vaishya Raju , Eschweiler Jörg , Hildebrand Frank , Maffulli Nicola 
Published: March 2023

AbstractBackgroundImmune-mediated conditions associated to Corona Virus Disease-19 (COVID-19) have been reported, including vasculitis, antiphospholipid antibody syndrome, myositis, and lupus. Emerging studies have reported the potential occurrence of reactive arthritis in patients previously infected with COVID-19. This systematic review summarised the current evidence on the occurrence of reactive arthritis in patients previously infected by COVID-19.MethodsThis study was conducted according to the 2020 PRISMA guidelines. All the clinical investigations describing the occurrence of reactive arthritis following COVID-19 were accessed. In September 2022, the following databases were accessed: PubMed, Web of Science, Google Scholar, Embase. The generalities of the study were extracted: author, year and journal of publication, country of the main author, study design, sample size, mean age, number of women, main results of the study. The following data on COVID-19 severity and management were retrieved: type of treatment, hospitalization regimes (inpatient or outpatient), admission to the intensive care unit, need of mechanical ventilation, pharmacological management. The following data on reactive arthritis were collected: time elapsed between COVID-19 infection to the onset of reactive arthritis symptoms (days), pharmacological management, type of arthritis (mono- or bilateral, mono- or polyarticular), extra-articular manifestations, presence of tenosynovitis or enthesitis, synovial examination at microscopic polarised light, imaging (radiography, magnetic resonance, sonography), clinical examination, laboratory findings.ResultsData from 27 case reports (54 patients) were retrieved, with a mean age of 49.8 ± 14.5 years. 54% (29 of 54 patients) were women. The mean time span between COVID-19 infection and the occurrence of reactive arthritis symptoms was 22.3 ± 10.7 days. Between studies diagnosis and management of reactive arthritis were heterogeneous. Symptoms resolved within few days in all studies considered. At last follow-up, all patients were minimally symptomatic or asymptomatic, and no additional therapy or attentions were required by any patient.ConclusionPoor evidence suggests that COVID-19 could target the musculoskeletal system causing reactive arthritis at its post infectious stage. COVID-19 can act as a causative agent or as a trigger for development of reactive arthritis even without presence of antibodies of rheumatological disorders. Treating physicians should have a high index of suspicion while treating post infectious COVID-19 patient with arthralgia.Level of evidenceLevel IV, systematic review.
Comparative study of four innovative earth-friendly platforms for rapid analysis of daclatasvir dihydrochloride: Application on different matrices
Authors: Sayed Rania A. , Mohamed Ahmed R. , Hassan Wafaa S. , Elmasry Manal S. 
Published: March 2023

Abstract
Background
Daclatasvir dihydrochloride has important roles not only in the management of COVID-19 pandemic symptoms but also in the treatment of chronic hepatitis C infection.

Objective
The current research presents four novel and simple platforms including silver-nanoparticles spectrophotometric technique and three electrochemical conductometric ones for daclatasvir analysis in its tablet, biological fluids, and dissolution media.

Methods
The spectrophotometric platform involved the synthesis of silvernanoparticles through a redox reaction between the reducing agent (daclatasvir) and the oxidizing agent (silver nitrate) in presence of polyvinylpyrrolidone as a stabilizing agent. The produced silver-nanoparticles have an intense surface plasmon resonance peak at 421 nm where the measured absorbance values were utilized for quantitative spectrophotometric determination of daclatasvir. While the electrochemical conductometric platforms involved the reaction of daclatasvir with three different precipitating reagents (silver nitrate, phosphomolybdic acid, and ammonium reineckate) to form ion associates between these reagents and daclatasvir in the aqueous system.

Results
All proposed platforms were validated in line with recommendations of the international conference on harmonization producing satisfactory outcomes within the agreed boundaries.

Conclusion
The proposed platforms are green alternatives for routine rapid assay of daclatasvir at the cheapest cost because their results were observed to be nearly similar to those of the reported platform. Moreover, the suggested spectrophotometric platform’s sensitivity can be employed for investigating daclatasvir bioequivalence.
HPLC-DAD technique for the quantification of a recently approved anti-diabetic triple combination along with two toxic official impurities: Toxicity confirmation aided by molecular docking application
Authors: Bahgat Eman A. , Hashem Hisham , Saleh Hanaa , Kamel Ebraam B. , Eissa Maya S. 
Published: March 2023

Abstract
Background
Gliflozins and gliptins are two distinct groups of pharmacological drugs that reduce blood glucose levels in individuals with type II diabetes in various ways that may perform their functions harmoniously. Trijardy® tablet, which contains empagliflozin, linagliptin, and metformin, was recently approved. The scientific database does not yet have a method that is sensitive enough to quantify the aforementioned medications in the presence of metformin official toxic impurities melamine and cyanoguanidine. Molecular docking modeling was utilized in this work to further prove the toxicity of melamine.

Methods
The five analytes listed before were quantified using RP-HPLC-diode array detector and a Zorbax® C8 column (4.6 × 250 mm, 5 μm) with isocratic mobile phase composed of acetonitrile and 0.05 M potassium dihydrogen phosphate buffer, which had been treated by ?-phosphoric acid to restore a pH of 4.0 (90:10, v/v) at a flow rate of 1.2 mL/min and the eluted peaks were scanned at 250 nm.

Conclusion
The utilization of the simplest isocratic elution mode give the current technique a significant time-and cost-saving benefit. The current method can quantify the triple therapy agents in the presence of each other as well as with two official toxic impurities of metformin in one short analytical run.
Evaluating the mosquito host range of Getah virus and the vector competence of selected medically important mosquitoes in Getah virus transmission
Authors: Azerigyik Faustus Akankperiwen , Faizah Astri Nur , Kobayashi Daisuke , Amoa-Bosompem Michael , Matsumura Ryo , Kai Izumi , Sasaki Toshinori , Higa Yukiko , Isawa Haruhiko , Iwanaga Shiroh , Ishino Tomoko 
Published: March 2023

Abstract
Background
The Getah virus (GETV) is a mosquito-borne Alphavirus (family Togaviridae) that is of significant importance in veterinary medicine. It has been associated with major polyarthritis outbreaks in animals, but there are insufficient data on its clinical symptoms in humans. Serological evidence of GETV exposure and the risk of zoonotic transmission makes GETV a potentially medically relevant arbovirus. However, minimal emphasis has been placed on investigating GETV vector transmission, which limits current knowledge of the factors facilitating the spread and outbreaks of GETV.

Methods
To examine the range of the mosquito hosts of GETV, we selected medically important mosquitoes, assessed them in vitro and in vivo and determined their relative competence in virus transmission. The susceptibility and growth kinetics of GETVs in various mosquito-derived cell lines were also determined and quantified using plaque assays. Vector competency assays were also conducted, and quantitative reverse transcription-PCR and plaque assays were used to determine the susceptibility and transmission capacity of each mosquito species evaluated in this study.

Results
GETV infection in all of the investigated mosquito cell lines resulted in detectable cytopathic effects. GETV reproduced the fastest in Culex tritaeniorhynchus- and Aedes albopictus-derived cell lines, as evidenced by the highest exponential titers we observed. Regarding viral RNA copy numbers, mosquito susceptibility to infection, spread, and transmission varied significantly between species. The highest vector competency indices for infection, dissemination and transmission were obtained for Cx. tritaeniorhynchus. This is the first study to investigate the ability of Ae. albopictus and Anopheles stephensi to transmit GETV, and the results emphasize the role and capacity of other mosquito species to transmit GETV upon exposure to GETV, in addition to the perceived vectors from which GETV has been isolated in nature.

Conclusions
This study highlights the importance of GETV vector competency studies to determine all possible transmission vectors, especially in endemic regions.

Graphical Abstract
Should acupuncture therapy be used for acute facial paralysis? A protocol for systematic review
Authors: Cheng Lu , Li Xiao-lin , Ying Yi , Du Shi-hao , Zhang Xu-dong , Guo Wei , Mi Shu-qi , Zhao Ji-ping 
Published: March 2023

Abstract
Background
Peripheral facial paralysis (PFP) results in functional disorder and social dysfunction, when it is under a severe condition at onset, long-term poor outcomes do occur. Different acupuncture methods have been reported to be potentially effective for shortening the disease course and reducing the occurrence of sequelae when they are applied at an early stage. Neuro edema is a common pathological feature in the acute phase, and many clinical studies have suggested its effect of reducing facial nerve edema. It is of value to estimate the effectiveness and safety of acupuncture treatment at the onset, and to assess the most suitable acupuncture method for the acute period.

Methods and analysis
All the RCTs and quasi-RCTs on acupuncture therapy for patients who is during acute stage of PFP will be included. The recovery rate of facial function, the time it takes to restore facial function and the odds of sequelae occurring will be the key parts we focus on. Psychological well-being and quality of life will also be evaluated. Literature searching will be conducted until December 31th, 2022 from eight databases systematically. Two reviewers will screen the literature and extract the data independently. RevMan software will be used for data analysis, and the version 2 of the Cochrane risk-of-bias tool (RoB 2) will be used to assess the certainty of evidence. Forest plots and summary findings will be generated. If data permits, a meta-analysis will be conducted.

Ethics and dissemination
Since this study will not involve clinical treatment of patients, ethics approval is not required. The result of this study will be submitted to a peer-reviewed journal for publication and as a proposal for clinical practice and further study on acupuncture treatment at the early stage of PFP.

Discussion
This review will summarize the evidence on the different type of acupuncture therapy for acute Bell’s palsy and Ramsay-Hunt syndrome. We anticipate that it would be safe and effective when applied to the acute phase of PFP, and some specific suitable acupuncture methods would be found resulting from this review.

Systematic review registration
International Prospective Register for Systematic Reviews (PROSPERO) number CRD42020205127
Landscape pattern analysis using GIS and remote sensing to diagnose soil erosion and nutrient availability in two agroecological zones of Southern Mali
Authors: Sanogo Karamoko , Birhanu Birhanu Zemadim , Sanogo Souleymane , Ba Abdramane 
Published: March 2023

AbstractBackgroundSoil is a basic natural resource for the existence of life on earth, and its health is a major concern for rural livelihoods. Poor soil health is directly associated with reduced agricultural land productivity in many sub-Saharan countries, such as Mali. Agricultural land is subjected to immense degradation and the loss of important soil nutrients due to soil erosion. The objective of the study was to diagnose the spatial distribution of soil erosion and soil nutrient variations under different land use in two agroecological zones of Southern Mali using the Geographical Information System (GIS) software, the empirically derived relationship of the Revised Universal Soil Loss Equation, in-situ soil data measurement and satellite products. The soil erosion effect on agricultural land productivity was discussed to highlight the usefulness of soil and water conservation practices in Southern Mali.ResultsThe results of the land use and land cover change analysis from 2015 to 2019 revealed significant area reductions in water bodies, bare land, and savanna woodland for the benefit of increased natural vegetation and agricultural land. There was significant variation in the annual soil loss under the different land use conditions. Despite recordings of the lowest soil erosion rates in the majority of the landscape (71%) as a result of field-based soil and water conservation practices, the highest rates of erosion were seen in agricultural fields, resulting in a reduction in agricultural land area and a loss of nutrients that are useful for plant growth. Spatial nutrient modelling and mapping revealed a high deficiency and significant variations (p < 0.05) in nitrogen (N), phosphorus (P), potassium (K), and carbon (C) in all land use and land cover types for the two agroecologies.ConclusionsThe study highlighted the inadequacies of existing field-based soil and water conservation practices to reduce soil erosion and improve landscape management practices. The findings of the study can inform land management planners and other development actors to strategize and prioritize landscape-based intervention practices and protect catchment areas from severe erosion for the enhanced productivity of agricultural fields.
Psychometric properties of an Arabic translation of the brief version of the difficulty in emotion regulation scale (DERS-16)
Authors: Fekih-Romdhane Feten , Kanj Gaelle , Obeid Sahar , Hallit Souheil 
Published: March 2023

AbstractBackgroundThe current study aimed to examine the psychometric properties of an Arabic translation of the short form of the Difficulty in Emotion Regulation Scale (DERS-16) in an Arabic-speaking population-based adult sample in Lebanon. In particular, the factorial structure, composite reliability, convergent validity and gender invariance were investigated.MethodsA total of 411 Lebanese adult participants (mean age of 32.86 ± 11.98 years, 75.4% females) took part of this cross-sectional web-based study. The forward and backward translation method was applied.ResultsFindings revealed good internal consistency of the Arabic DERS-16 total scale and five subscales (McDonald’s ω ranging from 0.81 to 0.95). Confirmatory factor analyses confirmed the five-factor solution of the scale and demonstrated strong measurement invariance across gender at the configural, metric, and scalar levels. No significant differences were found in all DERS-16 domains between men and women participants. Finally, the DERS-16 scores and sub-scores showed strong correlations with the Borderline Personality Questionnaire (r > .40), thus indicating its convergent validity.ConclusionOverall, the present findings suggest that the Arabic version of the DERS-16 may be a reliable and valid self-report measure that assesses ER difficulties as a multidimensional construct. Making the Arabic version of the DERS-16 available will hopefully strengthen its utilization for clinical and research purposes to benefit the millions of Arabic-speaking people worldwide.
A semi-supervised short text sentiment classification method based on improved Bert model from unlabelled data
Authors: Zou Haochen , Wang Zitao 
Published: March 2023

AbstractShort text information has considerable commercial value and immeasurable social value. Natural language processing and short text sentiment analysis technology can organize and analyze short text information on the Internet. Natural language processing tasks such as sentiment classification have achieved satisfactory performance under a supervised learning framework. However, traditional supervised learning relies on large-scale and high-quality manual labels and obtaining high-quality label data costs a lot. Therefore, the strong dependence on label data hinders the application of the deep learning model to a large extent, which is the bottleneck of supervised learning. At the same time, short text datasets such as product reviews have an imbalance in the distribution of data samples. To solve the above problems, this paper proposes a method to predict label data according to semi-supervised learning mode and implements the MixMatchNL data enhancement method. Meanwhile, the Bert pre-training model is updated. The cross-entropy loss function in the model is improved to the Focal Loss function to alleviate the data imbalance in short text datasets. Experimental results based on public datasets indicate the proposed model has improved the accuracy of short text sentiment recognition compared with the previous update and other state-of-the-art models.
Significant risk of repeat adverse outcomes in recurrent gestational diabetes pregnancy: a retrospective cohort study
Authors: Lau Sue Lynn , Chung Alex , Kao Joanna , Hendon Susan , Hawke Wendy , Lau Sue Mei 
Published: March 2023

Abstract
Background
The risk of adverse outcomes in recurrent GDM pregnancy has not been well documented, particularly in women who have already had an adverse outcome. The aim of this study was to compare the risk of recurrent adverse delivery outcome (ADO) or adverse neonatal outcome (ANO) between consecutive gestational diabetes (GDM) pregnancies.

Methods
In this retrospective study of 424 pairs of consecutive (“index” and “subsequent”) GDM pregnancies, we compared the risk of ADO (instrumental delivery, emergency Caesarean section) and ANO (large for gestational age (LGA and small for gestational age (SGA)) in women with and without a history of adverse outcome in their index pregnancy.

Results
Subsequent pregnancies had higher rates of elective Caesarean (30.4% vs 17.0%, p < 0.001) and lower rates of instrumental delivery (5% vs 13.9%, p < 0.001), emergency Caesarean (7.1% vs 16.3%, p < 0.001) and vaginal delivery (62.3% vs 66.3%, p = 0.01). Index pregnancy adverse outcome was associated with a higher risk of repeat outcome: RR 3.09 (95%CI:1.30,7.34) for instrumental delivery, RR 2.20 (95%CI:1.06,4.61) for emergency Caesarean, RR 4.55 (95%CI:3.03,6.82) for LGA, and RR 5.01 (95%CI:2.73,9.22) for SGA). The greatest risk factor for subsequent LGA (RR 3.13 (95%CI:2.20,4.47)) or SGA (RR 4.71 (95%CI:2.66,8.36)) was having that outcome in the index pregnancy.

Conclusion
A history of an adverse outcome is a powerful predictor of the same outcome in the subsequent GDM pregnancy. These high-risk women may warrant more directed management over routine GDM care such as altered glucose targets or increased frequency of ultrasound assessment.
Killer cell immunoglobulin receptor diversity and its relevance in the human host’s response to HIV infection in African populations
Authors: Mukisa John , Amujal Marion , Sande Obondo J. , Joloba Moses L. , Jjingo Daudi , Kateete David P. , Mardon Graeme , Matshaba Mogomotsi , Hanchard Neil , Hollenbach Jill A. 
Published: March 2023

Abstract
Host response to the human immune deficiency virus (HIV) involves both the innate and adaptive immune systems. As part of the innate immune system, the killer cell immunoglobulin-like receptors (KIRs) found on natural killer cells and some T-lymphocytes are genetically diverse and play key functions in the host response against viral pathogens. In the last decade, there has been substantial growth in sequencing technologies and bioinformatics capacity to understand human host genetics, including KIR. However, there is limited literature on how the KIR diversity informs the perspectives on HIV disease states in understudied African settings. A better understanding of the effects of KIRs on the host’s immune response to HIV in African settings is essential to inform strategies to develop more effective therapies and vaccines to improve health among people living with HIV (PLWH). In this paper, we review KIR diversity, the role of KIR immunogenetic variation in the human host response to HIV, discuss current perspectives on the studies to assess the relationship between KIR diversity and the HIV disease continuum, and suggest future research prospects.
Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer’s disease
Authors: Kaneko Ryusei , Matsui Ako , Watanabe Mahiro , Harada Yoshihiro , Kanamori Mitsuhiro , Awata Natsumi , Kawazoe Mio , Takao Tomoaki , Kobayashi Yutaro , Kikutake Chie , Suyama Mikita , Saito Takashi , Saido Takaomi C. , Ito Minako 
Published: March 2023

Abstract
Background
Alzheimer’s disease (AD) is one of the neurodegenerative diseases and characterized by the appearance and accumulation of amyloid-β (Aβ) aggregates and phosphorylated tau with aging. The aggregation of Aβ, which is the main component of senile plaques, is closely associated with disease progression. AppNL-G-F mice, a mouse model of AD, have three familial AD mutations in the amyloid-β precursor gene and exhibit age-dependent AD-like symptoms and pathology. Gut-brain interactions have attracted considerable attention and inflammatory bowel disease (IBD) has been associated with a higher risk of dementia, especially AD, in humans. However, the underlying mechanisms and the effects of intestinal inflammation on the brain in AD remain largely unknown. Therefore, we aimed to investigate the effects of intestinal inflammation on AD pathogenesis.

Methods
Wild-type and AppNL-G-F mice at three months of age were fed with water containing 2% dextran sulfate sodium (DSS) to induce colitis. Immune cells in the brain were analyzed using single-cell RNA sequencing (scRNA-seq) analysis, and the aggregation of Aβ protein in the brain was analyzed via immunohistochemistry.

Results
An increase in aggregated Aβ was observed in the brains of AppNL-G-F mice with acute intestinal inflammation. Detailed scRNA-seq analysis of immune cells in the brain showed that neutrophils in the brain increased after acute enteritis. Eliminating neutrophils by antibodies suppressed the accumulation of Aβ, which increased because of intestinal inflammation.

Conclusion
These results suggest that neutrophils infiltrate the AD brain parenchyma when acute colitis occurs, and this infiltration is significantly related to disease progression. Therefore, we propose that neutrophil-targeted therapies could reduce Aβ accumulation observed in early AD and prevent the increased risk of AD due to colitis.