bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuberculosis screening in hidradenitis suppurativa patients on tumor necrosis factor inhibitors: a retrospective chart review
Authors: Byrnes Katherine G , Flowers Richard H 
Published: January 2025

Abstract
Hidradenitis suppurativa (HS) patients treated with tumor necrosis factor (TNF) inhibitors are at an increased risk for tuberculosis (TB) reactivation, necessitating baseline latent TB infection (LTBI) screening. However, evidence regarding the value of periodic LTBI screening in this population is limited. In this single-center retrospective chart review, we investigated the LTBI rate in HS patients treated with adalimumab or infliximab. The cohort included 92 patients with an average treatment duration of 37.4 months and a median Interferon-Gamma Release Assay (IGRA) number of 3. The cumulative observation time was 286 person-years. Our investigation found no positive LTBI results in HS patients on TNF inhibitors, challenging clinicians to reconsider the utility of serial screening for such patients who are otherwise at low risk for TB. Further research is essential for the development of evidence-based guidelines to optimize patient care and healthcare resource allocation.
Responsible governance of generative AI: conceptualizing GenAI as complex adaptive systems
Authors: Janssen Marijn 
Published: January 2025

Abstract
Organizations increasingly use Generative Artificial Intelligence (AI) to create strategic documents, legislation, and recommendations to support decision-making. Many current AI initiatives are technology-deterministic, whereas technology co-evolves with the social environment, resulting in new applications and situations. This paper presents a novel view of AI governance by organizations from the perspective of complex adaptive systems (CASs). AI is conceptualized as a socio-technological and adaptive system in which people, policies, systems, data, AI, processes, and other elements co-evolve. The CAS lens draws attention to focusing AI governance on the entire organization, taking an outward perspective and considering public values and societal concerns. Although there is no shortage of AI governance instruments, they differ in their effectiveness, and combinations of appropriate mechanisms should be selected to deal with AI’s evolving nature and complexity. A major challenge is that no responsibility, and therefore accountability, is taken due to the lack of understanding of the full socio-technological CAS. As such, joint accountability is needed in which involved parties work together.
Account-Holding Intensity: Six Reasons Why We Need to Look at Both Frequency and Diligence
Authors: Leidorf-Tidå Benjamin , Brandsma Gijs Jan 
Published: January 2025

ABSTRACT
Measurements of accountability tend to gauge account-holding powers or frequencies while neglecting the quality of the account-holding process. In this article we address this with a conceptual innovation, defining account-holding intensity as a combination of both the frequency and the diligence of account holding. We propose this as a framework that is sensitive to both the quantity and the quality of account holding. Subsequently, we provide six reasons why both frequency and diligence matter and should be analyzed and measured in tandem. We illustrate the usefulness of our framework with an example study where we apply it, both in a survey and in interviews, in the context of multiple European Union (EU) account holders overseeing the activities of EU agencies. This analysis showcases all of the six reasons outlined for using this framework.
Creating codes of ethics for public health professionals and institutions
Authors: Thomas James C , Schröder-Bäck Peter , Czabanowska Katarzyna , Athanasopoulos Paul , Mfutso-Bengo Joseph , Baldwin-SoRelle Carrie , Strohmeier Lena , Tahzib Farhang 
Published: January 2025

Abstract

Background
The World Health Organization and the Association of Schools of Public Health in the European Region called for the professionalization of the public health workforce, including the creation of codes of ethics. In this article, the Public Health Ethics and Law Network provides guidance on creating such codes, based on values and principles commonly identified for public health.

Methods
Our interest was in codes addressing public health broadly rather than disciplines within public health. Public Health codes of ethics are typically published on agency and organization websites rather than peer-reviewed literature. We searched several online databases, such as PubMed; United States government websites; Spanish language websites; and English language websites for public health organizations.

Results
We synthesized the principles found into 10 adjectives—such as caring, responsive, and trustworthy—with short elaborations. These terms are practical, for non-philosophers, and provide flexibility for adaptation to country contexts.

Conclusions
The creation of a code of ethics should be followed by the identification and building of ethical competencies and capacity for public health professionals and institutions. There are plans to collaborate with pilot sites in the use and generation of further learning, and additional assistance for competencies and other resources to support a code of ethics and competencies.
Amniocentesis in Pregnancies at or Beyond 24 Weeks: An International Multicenter Study
Authors: Zemet Roni , Maktabi Mohamad Ali , Tinfow Alexandra , Giordano Jessica L. , Heisler Thomas M. , Yan Qi , Plaschkes Roni , Stokes Jenny , Walsh Jennifer M. , Corcoran Siobhán , Schindewolf Erica , Miller Kendra , Talati Asha N. , Miller Kristen A. , Blakemore Karin , Swanson Kate , Ramm Jana , Bedei Ivonne , Sparks Teresa N. , Jelin Angie C. , Vora Neeta L. , Gebb Juliana S. , Crosby David A. , Berkenstadt Michal , Weisz Boaz , Wapner Ronald J. , Van Den Veyver Ignatia B. 
Published: January 2025

(Abstracted from Am J Obstet Gynecol 2024:S0002-9378(24)00693-8)
Amniocentesis, a standard method for obtaining fetal samples for genetic testing since the 1970s, is typically performed between 15 and 22 weeks of gestation. While useful for detecting chromosomal or single-gene fetal disorders, it carries low-incidence risks such as pregnancy loss, preterm prelabor rupture of membranes, chorioamnionitis, and fetal needle injury.
Incorporation of Vasa Previa Screening Into a Routine Anomaly Scan: A Single Center Cohort Study
Authors: Nwandison Millicent , Daly-Jones Elizabeth , Drought Alexandra , Story Lisa , De-Rosnay Philippe , Sebire Neil , Nyberg David , Oyelese Yinka 
Published: January 2025

(Abstracted from Acta Obstet Gynecol Scand 2024;103:1466–1473)
Vasa previa (VP) is a serious obstetrical complication in which fetal vessels lie unprotected near the cervical opening, posing a high risk of vessel rupture and fetal exsanguination if undiagnosed before delivery. However, antenatal detection and planned cesarean delivery can result in excellent outcomes.
Epidemiology and Management of Gestational Diabetes
Authors: Sweeting Arianne , Hannah Wesley , Backman Helena , Catalano Patrick , Feghali Maisa , Herman Willliam H. , Hivert Marie-France , Immanuel Jincy , Meek Claire , Oppermann Maria Lucia , Nolan Christopher J. , Ram Uma , Schmidt Maria Inês , Simmons David , Chivese Tawanda , Benhalima Katrien 
Published: January 2025

(Abstracted from Lancet 2024;404:175–192)
The International Association of Diabetes and Pregnancy Study Groups (IADPSG) estimates the prevalence of gestational diabetes mellitus (GDM) to be 14% worldwide. Of those with GDM, 30% to 70% have early GDM, which is diagnosed before 20 weeks of gestation.
When Is it Necessary to Perform Biopsy in Asymptomatic Postmenopausal Women With Incidental Finding of Thickened Endometrium?
Authors: Wang Jing , Peng Xuebing , Xia Enlan , Xiao Yu , Liu Yuhuan , Su Dan , Xu Jianfeng , Li Tin-Chiu , Huang Xiaowu 
Published: January 2025

(Abstracted from Eur J Obstet Gynecol Reprod Biol 2024:302:104–110
Endometrial thickening without vaginal bleeding is frequently considered an indication for referral for pathological evaluation, though gynecologists debate whether this is necessary in women who are asymptomatic and postmenopausal. Current guidelines suggest biopsy when endometrial thickness reaches more than 4–5 mm and individuals experience postmenopausal bleeding, even though up to 15% of endometrial cancer cases occur in individuals without postmenopausal bleeding.
Effectiveness of Workplace Cancer Screening Interventions: A Systematic Review
Authors: Mon Hsu Myat , Robb Kathryn A. , Demou Evangelia 
Published: January 2025

(Abstracted from BMC Cancer 2024;24:999
Cancer screenings have been shown to improve outcomes through early detection but can also result in negative side effects. Current recommendations revolve around using screenings that are the least invasive, with lowest harm and highest benefit depending on the type of cancer and age group of individuals.
A comprehensive review of conservative therapies for female stress urinary incontinence: Advancements, efficacy, and future directions
Authors: Luo Can , Niu Xiaoyu 
Published: January 2025

Abstract
Pelvic floor dysfunction poses a significant challenge to women worldwide. Female urinary incontinence is one of the most prevalent types of pelvic floor dysfunctions, affecting at least 50% of females, particularly those who are pregnant or menopausal. Among the various urinary incontinence subtypes, stress urinary incontinence takes the lead, characterized by involuntary urine leakage during activities that increase intra-abdominal pressure, such as sneezing, coughing, laughing, or exercising. This comprehensive review explores the latest advancements and critical insights into conservative treatments for stress urinary incontinence. Stress urinary incontinence symptoms result in profound physical and psychological consequences for individuals and impose a substantial medical and economic burden on society; however, only 5%–10% seek professional help. This narrative review meticulously examines a spectrum of interventions, ranging from lifestyle modifications to emerging modalities, such as laser treatment and electroacupuncture.
Department of Defense Military Treatment Facility and Community Care Costs After Traumatic Brain Injury in Service Members and Veterans Treated in Veterans Affairs Polytrauma Rehabilitation Centers: A VA TBI Model Systems Study
Authors: Dismuke-Greer Clara E. , Almeida Emily , Ryan Jessica L. , Nakase-Richardson Risa 
Published: January 2025

Objective: To estimate cost models of military traumatic brain injury (TBI) that can provide evidence for future cost-effectiveness analyses highlighted as a gap in the recent National Academies of Sciences, Engineering, and Medicine (NASEM) report on accelerating progress in TBI. Setting: Military Treatment Facilities (MTFs) and community care facilities within the Military Health System (MHS). Participants: 1,101 service members/veterans (SMV) diagnosed with a TBI and treated at a Veterans Administration (VA) Polytrauma Rehabilitation Center (PRC). Design: This retrospective study analyzed healthcare costs in MTFs and community care facilities among SMVs diagnosed with TBI and treated at 1 of 5 VA PRCs. MTF and community care records were assessed. Main Measures: Annual MTF and community care inpatient and outpatient costs. TBI disability was measured by the Disability Rating Scale (DRS). Results: Mean age was 31, with 9.8 years of service, and time in MHS post-TBI was 7.18 years. The mean annual inpatient cost was $22,126 in MTFs and $112,218 in community. The mean annual outpatient cost was $17,983 in MTFs and $9,141 in community. Each year of age was associated with $8,276 (95% CI 4,068–12,483), each day of acute care length of stay (LOS) before rehabilitation with $1,024 (95% CI 8–2039), and each additional point on the DRS with $10,858 (95% CI 4,273–17,442) higher costs. Conclusion: Findings describe MHS annualized costs across acute and chronic stages in MTFs and the community and their association with SMVs’ TBI disability measured by the DRS. These foundational cost data are critical for informing future hybrid design trials in TBI that examine the economic impact of TBI interventions being studied in future research.
Does Concomitant Use of Antidepressants and Direct Oral Anticoagulants Increase the Risk of Bleeding?
Authors: Weng Jinyan , Lan Ruying 
Published: January 2025

Abstract

Purpose
To evaluate the risk of bleeding associated with the simultaneous administration of antidepressants (ADs) and direct oral anticoagulants (DOACs).

Methods
PubMed, Embase, and Scopus databases were searched for papers that focused on the concomitant administration of ADs and DOACs and presented data on the bleeding outcomes. The comparator group of interest was subjects who received only DOACs. Besides the overall pooled analysis, irrespective of the primary disease condition, we were also interested in studies involving patients with atrial fibrillation (AF). We therefore included studies with relevant comparisons (AD with DOACs, compared to DOACs alone), regardless of the reported underlying condition. Thereafter, we conducted a sensitivity analysis to refine estimates specific to AF. Clinical trials and observational studies were eligible. Pooled effect sizes were reported as relative risk (RR) for studies with cohort design and as odds ratio (OR) for case-control studies.

Results
Ten studies were included. Overall pooled analysis showed that treatment with both DOAC and selective serotonin reuptake inhibitor and serotonin and norepinephrine reuptake inhibitor (SSRI/SNRI) was associated with significantly higher risk of major bleeding (cohort: RR 1.25, 95% CI: 1.07–1.47; case-control: OR 1.40, 95% CI: 1.15–1.69). The risk of intracranial bleeding was found to be increased when cohort studies were pooled (RR 1.44, 95% CI: 1.24–1.66), but not with pooling of case-control studies (OR 1.58, 95% CI: 0.43–5.75). The risk of gastrointestinal bleeding and transient ischemic attack (TIA)/ischemic stroke was comparable between the 2 groups (DOAC + SSRI/SNRI vs DOAC only group).

Conclusions
Our results indicate that combined SSRIs/SNRIs and DOAC treatment may be associated with increased incidence of major and intracranial bleeding, further emphasizing the importance of caution when considering their concomitant use.
Results of a 14-Day Challenge to Improve Dispositional Gratitude in an Academic Nursing Setting
Authors: Phillips Amelia , Pryor Stacy , Carden Abigail , Torr Gillian , Menon Usha 
Published: January 2025

Background:
The benefits of engaging in regular, intentional gratitude practice have been well studied. Interventions incorporating simple gratitude practices, such as the 3 Good Things exercise, may be ideal for increasing dispositional gratitude levels within an academic setting.

Purpose:
To assess the impact of a 14-day gratitude-focused wellness intervention on increasing gratitude levels among nursing students, faculty, and staff.

Methods:
Students, faculty, and staff from one College of Nursing were invited to participate in a 14-day gratitude challenge. The Gratitude Resentment and Appreciation Scale – Short Form assessed gratitude levels pre- and post-challenge.

Results:
Dispositional gratitude scores increased significantly among participants overall (P = .006). Furthermore, dispositional gratitude levels increased significantly regardless of whether participants were already using a tool to practice gratitude at the start of the challenge.

Conclusions:
Results demonstrate that a 14-day gratitude-focused intervention can improve dispositional gratitude levels among members of the academic nursing community.
Obstetric Characteristics and Outcomes of Gestational Carrier Pregnancies: A Systematic Review and Meta-analysis
Authors: Matsuzaki Shinya , Masjedi Aaron D. , Matsuzaki Satoko , Anderson Zachary S. , Erickson Katherine V. , Mandelbaum Rachel S. , Ouzounian Joseph G. , Paulson Richard J. , Matsuo Koji 
Published: January 2025

(Abstracted from JAMA Network Open 2024;7:e2422634)
Gestational carriers (GCs) are surrogates who carry a pregnancy without a genetic link to the fetus, using embryos created from the gametes of donors or intended parents. This approach offers a valuable option for individuals facing biological, ethical, medical, or psychosocial challenges to carrying a pregnancy themselves.
Uterine Contractile Activity and Neonatal Outcome—A Blind Analysis of a Randomized Controlled Trial Cohort
Authors: Juhantalo Milla , Hautakangas Tuija , Palomäki Outi , Uotila Jukka 
Published: January 2025

(Abstracted from Acta Obstet Gynecol Scand 2024;103:1396–1407)
For a successful delivery, sufficient contractions are needed. However, when the uterine contractile activity is too powerful, contractions are too long, or relaxation time is insufficient, and oxygenated blood flow can be temporarily restricted to the fetus.
A Mixed Method Evaluation of Practitioners’ Perspectives on Implementation Strategies for Healthy Eating and Active Living Policy, Systems, and Environmental Changes
Authors: Houghtaling Bailey , Pradhananga Nila , Holston Denise , Cater Melissa , Balis Laura 
Published: January 2025

Context:
The National Cooperative Extension System is a leader in delivering healthy eating and active living (HEAL) policy, systems, and environmental (PSE) changes; however, these interventions are challenging, and technical assistance efforts often misalign with implementation science concepts.

Objective:
The study objective was to understand the importance of implementation strategies and tailoring needs to support Louisiana Nutrition and Community Health (NCH) practitioners’ delivery of rural HEAL PSE changes.

Design:
An explanatory sequential mixed method study design was used, including a survey to rank the importance of implementation strategies for HEAL PSE changes and a follow-up interview. A review of available implementation strategies (practice activities/resources) for Louisiana HEAL PSE changes was also conducted.

Setting:
This study occurred within Louisiana and focused on NCH practitioners’ ongoing HEAL PSE change efforts throughout the state, with emphasis on rural community settings.

Participants:
All NCH practitioners were eligible to participate. “Practitioners” included Extension NCH administrators and agents/educators directly delivering HEAL PSE changes.

Main Outcomes:
The main quantitative outcome was the ranked importance of implementation strategies to support NCH practitioners’ delivery of HEAL PSE changes. For explanatory interviews, perceptions of higher and lower ranked implementation strategies and tailoring opportunities were of interest. The alignment of available activities/resources with possible implementation strategies was also assessed.

Results:
Highly ranked implementation strategies focused on engaging dedicated community partners and community members and starting small to ensure success, generate buy-in, and demonstrate feasibility. Opportunities for capacity building in these areas were identified. A lower ranked implementation strategy, changing organizational structures, was considered less likely to occur but possibly necessary to improve job satisfaction, retention, and return on investment. Available activities/resources overlapped with a few available implementation strategies.

Conclusions:
This study identified opportunities to use implementation science concepts to improve program support for NCH practitioners delivering complex HEAL PSE changes.
Associations Between Sugar-Sweetened Beverage Taxes and Weight Outcomes Among US Adolescents
Authors: Cui Dinghe , Baum Christopher F. , Hawkins Summer Sherburne 
Published: January 2025

Given the recent implementation and preemption of sugar-sweetened beverage taxes across the United States, we aimed to evaluate the associations between sugar-sweetened beverage (SSB) taxes and adolescent weight-related outcomes using data on 364,540 adolescents drawn from 1999 to 2021 district Youth Risk Behavior Surveys. We used difference-in-differences models to assess the associations and the potential mediating roles of SSBs, milk, and 100% fruit juice consumption. We found that a one cent per ounce increase in SSB taxes was associated with a 0.26 lower body mass index (P < .01), and a 2.19 (P < .01) and 1.68 (P < .01) percentage point decrease in the probability of being affected by overweight and obesity, respectively. SSB consumption had a mediating role, as tax increases were associated with a 2.45 (P < .01) percentage point decrease in adolescents’ probability of drinking any SSB. Milk and 100% fruit juices likely also played a role, as we found changes in their consumption in response to tax increases.
Increased circulatory Krebs cycle metabolites in sepsis is associated with increased interleukin-6 release and worse survival
Authors: Chung Kuei-Pin , Chen Yi-Hsuan , Chen Yi-Jung , Chien Jung-Yien , Kuo Han-Chun , Huang Yen-Tsung , Ruan Sheng-Yuan , Lin Yu-Li , Chen Yen-Fu , Keng Li-Ta , Kuo Lu-Cheng , Ku Shih-Chi , Kuo Ching-Hua , Yu Chong-Jen ,   TAiwan CollaboraTive Intensive Care Study group(TACTICS)
Published: January 2025

ABSTRACT

Objective
Recent studies have proposed that Krebs cycle metabolites may serve as potential biomarkers for prognosis in sepsis. However, whether these metabolites are associated with disease severity and can be applied to improve the effectiveness of current prognosis assessment in sepsis remains unclear and is explored in this study.

Methods
This prospective multicenter cohort study was conducted in medical intensive care units (ICUs). From December 2019 to September 2022, consecutive patients admitted to medical ICUs for sepsis were screened and recruited. Plasma samples were obtained for measurements of cytokines and Krebs cycle metabolites, including citrate/isocitrate, cis-aconitate, alpha-ketoglutarate, succinate, fumarate and malate.

Results
In total, 97 patients admitted for sepsis were enrolled in the study. The 28-day mortality rate was 17.5%, and non-survivors exhibited significantly increased plasma lactate levels and Sequential Organ Failure Assessment (SOFA) scores. Plasma levels of Krebs cycle metabolites were significantly correlated with both plasma lactate and interleukin-6 levels. Except for citrate/isocitrate, all Krebs cycle metabolites were significantly elevated in patients with acute kidney injury. Multivariate Cox proportional hazard models, adjusted for plasma lactate levels and SOFA scores, revealed that plasma levels of alpha-ketoglutarate (adjusted hazard ratio [HR]: 2.404, P = 0.002), fumarate (adjusted HR: 1.904, P = 0.001) and malate (adjusted HR: 1.327, P = 0.019) were associated with increased risk of 28-day mortality.

Conclusions
Study findings indicate that Krebs cycle metabolites, particularly alpha-ketoglutarate, fumarate, and malate, when applied with SOFA score, might enhance prognostic assessment in patients with sepsis.