bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of t(14;18) translocation breakpoint site with clinical characteristics in follicular lymphoma
Authors: Panjan Matej , Boltezar Lucka , Novakovic Srdjan , Kokovic Ira , Jezersek Novakovic Barbara 
Published: July 2023

Abstract

Background
t(14;18)(q32;q21) translocation is an important genetic feature of follicular lymphoma resulting in antiapoptotic B-cell lymphoma 2 (BCL2) protein overexpression. On chromosome 18 breakpoint-site variation is high but does not affect BCL2. Breakpoint most commonly occurs at major breakpoint region (MBR) but may happen at minor cluster region (mcr) and between MBR and mcr at 3′MBR and 5′mcr. The aim of this study was to analyze the correlation of t(14;18)(q32;q21) breakpoint site with clinical characteristics in follicular lymphoma.

Patients and methods
We included patients diagnosed with follicular lymphoma who received at least 1 cycle of systemic treatment and had the t(14;18)(q32;q21) translocation detected by polymerase chain reaction (PCR) at MBR, mcr or 3′MBR prior to first treatment. Among patients with different breakpoints, sex, age, disease grade, stage, B-symptoms, follicular lymphoma international prognostic index (FLIPI), presence of bulky disease, progression free survival and overall survival were compared.

Results
Of 84 patients, 63 had breakpoint at MBR, 17 at mcr and 4 at 3′MBR. At diagnosis, the MBR group had a significantly lower disease stage than the mcr group. Although not significant, in the MBR group we found a higher progression-free survival (PFS) and overall survival (OS), lower grade, age, FLIPI, and less B-symptoms.

Conclusions
Compared to patients with mcr breakpoint, those with MBR breakpoint seem to be characterised by more favourable clinical characteristics. However, a larger study would be required to support our observation.
IMPLEMENTASI PENDIDIKAN KARAKTER DI SEKOLAH DASAR
Authors: Belinda Lebyana Norma , Halimah Leli 
Published: July 2023

Pendidikan merupakan salah satu faktor terpenting dalam membangun pembentukan karakter seseorang. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana implementasi pendidikan karakter di SDN Anggadita I dan mendeskripsikan bagaimana pendidikan karakter dilaksanakan di sekolah tersebut. Metode penelitian ini menggunakan kualitatif dengan pendekatan studi kasus. Teknik pengumpulan data dilakukan dengan menggunakan wawancara, observasi dan dokumentasi. Temuan penelitian ini menunjukkan bahwa: 1) nilai karakter yang diterapkan adalah religius, tanggung jawab, jujur, dan toleransi. 2) Melalui pembiasaan, implementasi dan konsep pendidikan karakter di SDN Anggadita I. 3). Strategi pendidikan karakter guru antara lain selalu mengingatkan siswa akan hal-hal yang baik, memberi peringatan tegas, memberi contoh secara langsung atau menjadi panutan, terlibat dalam kegiatan rutin atau pembiasaan, dan meningkatkan kesadaran siswa. 4) Hambatan pelaksanaan pendidikan karakter di SDN Anggadita I adalah faktor guru, orang tua, lingkungan, dan siswa..Kata kunci: implementasi; pendidikan karakter; strategi pendidikan. IMPLEMENTATION OF CHARACTER EDUCATION IN ELEMENTARY SCHOOLS ABSTRACTEducation is one of the most important factors in building the formation of one's character. The purpose of this study is to find out how character education is implemented at SDN Anggadita I and to describe how character education is implemented at that school. This research method uses a qualitative case study approach. Data collection techniques were carried out using interviews, observation and documentation. The findings of this study indicate that: 1) the character values applied are religious, responsible, honest and tolerant. 2) Through habituation, implementation and the concept of character education at SDN Anggadita I. 3). Teacher character education strategies include always reminding students of good things, giving strict warnings, giving direct examples or being role models, engaging in routine activities or habituation, and increasing student awareness. 4) Obstacles to the implementation of character education at SDN Anggadita I are the factors of teachers, parents, environment, and students.Keywords: implementation; character building; educational strategy.
Measurement and Kinetics Prediction of Undiluted Methane–Oxygen Laminar Flame Speeds
Authors: Turner Mattias A. , Petersen Eric L. 
Published: July 2023

This study presents new [Formula: see text] laminar flame speed ([Formula: see text]) data for a wide range of equivalence ratios ([Formula: see text]) at low pressure (0.5 atm) and multiple initial pressures (0.5–3 atm) at an equivalence ratio far from stoichiometry ([Formula: see text]). All experiments were conducted at room temperature using spherically expanding flames. At 0.5 atm, [Formula: see text] peaked slightly lean, reaching a maximum of 411 cm/s near [Formula: see text]. Far from stoichiometry, [Formula: see text] was approximately 72 and 34 cm/s at [Formula: see text] and 2.4, respectively. [Formula: see text] predictions were computed using several commonly cited chemical kinetics mechanisms for methane combustion, with performance approximately the same for all mechanisms. Every mechanism underpredicted [Formula: see text] at 0.5 atm for [Formula: see text], with performance especially poor near stoichiometry ([Formula: see text] underprediction near the peak). For [Formula: see text], experiments were conducted for pressures from 0.5 to 3.0 atm, showing that [Formula: see text] varies approximately according to the power law [Formula: see text]. The mechanisms captured this pressure dependency, with GRI-Mech 3.0 performing especially well. Sensitivity analysis shows that many reaction adjustments are necessary to solve the underprediction near stoichiometry, with [Formula: see text] potentially a reaction of interest.
Effect of Aspect Ratio on Swept-Wing Dynamic Stall
Authors: Hammer Patrick R. , Garmann Daniel J. , Visbal Miguel R. 
Published: July 2023

The role of aspect ratio on the dynamic stall process of swept finite wings is investigated using high-fidelity implicit large-eddy simulations. Two aspect ratios ([Formula: see text] and 8) are explored for a 30 deg swept wing (NACA 0012) pitching sinusoidally from an initial incidence of 4 deg to a maximum angle of attack of 22 deg with a reduced frequency of [Formula: see text] over one pitching cycle. The flow is simulated at a chord Reynolds number of [Formula: see text] and a freestream Mach number of [Formula: see text]. The unsteady three-dimensional flowfield for the higher-aspect-ratio wing showed similarity with the lower-aspect-ratio wing through the initial flow separation at the leading edge. Motion-induced effects promoted earlier initiation of the unsteady vortical structures at higher aspect ratios. The vortex tube at the larger span underwent significant distortion, which contrasted with the [Formula: see text] vortex observed at the lower span. The vortical structure eventually interacted with the trailing-edge vortex, which was not observed at [Formula: see text]. Examination of the unsteady loads detailed a larger lift slope, mean values, peak values, and earlier stall as the aspect ratio increased. Analysis of the aerodynamic pitch damping suggests the [Formula: see text] wing is less susceptible to local torsional instabilities than the [Formula: see text] wing.
Clinician’s Corner: Meeting family care needs during resuscitative procedures and cardiac arrest in the emergency department
Authors: Douma Matthew , Picard Christopher , Su Karlin , Myhre Calah , Smith Katherine , Montgomery Carmel 
Published: July 2023

Emergency nurses in Canada provide care to many thousands of critically ill and injured patients, and their families, each year (Rowe et al., 2020). Unfortunately, some Emergency Department (ED) patients and families report a lack of psychosocial and emotional caring (Gordon et al., 2010). Many resuscitative processes and procedures have been described as dehumanizing and traumatic for families (De Stefano et al., 2016; Jang & Choe, 2019). Significant negative emotional and physiological impacts may remain after hospitalization for the patient and their loved ones, whether receiving care for medical, (Davidson & Harvey, 2016) trauma, (McGahey-Oakland et al., 2007) or cardiac arrest presentations (Leske et al., 2013). Families of patients who survive (and those who do not survive) have reported persistent negative psychological effects weeks and months after receiving care in the ED (Jang & Choe, 2019; Keyes et al., 2014; Sawyer et al., 2020).
Identification and Quantification of the Component Composition of the Active Substance Gentamicin Sulfate by <sup>1</sup>Н and <sup>13</sup>С NMR Spectroscopy
Authors: Moiseev S. V. , Kuz’mina N. E. , Severinova E. Yu. , Simonova E. P. , Kosenko V. V. 
Published: July 2023

Gentamicin sulfate is a broad-spectrum bactericidal aminoglycoside antibiotic produced by Micromonospora purpurea and used in clinical practice as an active substance containing a mixture of gentamicins C1 and C2. Gentamicin content is a standardised parameter controlled as part of a pharmaceutical product review. Currently, the quality control of the active substance gentamicin sulfate involves the use of high-performance liquid chromatography (HPLC) for the indirect identification of the component composition by comparison with a reference standard and for its quantification by calibration against the reference standard.The aim of the study was to develop a procedure for identifying and quantifying the components of the active substance gentamicin sulfate using nuclear magnetic resonance (NMR) spectroscopy that would not require reference standards.Materials and methods. The authors studied a sample of the active substance gentamicin sulfate using an Agilent DD2 NMR spectrometer operating at 600 MHz to record NMR spectra and an Agilent 1200 HPLC system equipped with a multiple wavelength detector (MWD) to obtain chromatograms.Results. Having determined the spectral properties of the C1, C1A, C2, C2A and C2B gentamicins comprising the active substance, the authors observed characteristic signals of the same type that corresponded to each of the gentamicins and did not overlap with other signals in the 1H and 13C spectra. These characteristic signals provided spectral markers indicative of the gentamicins of interest in the sample, with normalised integrated intensities equal to the mole fractions of the analytes. The authors compared NMR and HPLC measurements of the active substance composition.Conclusions. The authors developed a procedure for identifying and quantifying the constituents of the active substance gentamicin sulfate by 1H and 13C NMR spectroscopy, which requires less effort than HPLC procedures and no reference standards for the intended applications.
IDENTIFIKASI SIFAT FISIKA TANAH DAN UPAYA PEMULIHAN TANAH PERTANIAN MENUNJANG KETAHANAN PANGAN DI SUMBAR
Authors: Mariati Heny , Jamilah Jamilah , Arsita Sari 
Published: July 2023

Penggunaan tanah sebagai tempat budidaya tanaman pangan, sayuran, dan perkebunan sering kurang memperhatikan azas pengawetan tanah. Penggunaan pupuk buatan yang sangat intensif, serta pupuk organik yang masih minim membuat kualitas tanah semakin menurun. Pengolahan tanah secara intensif di lahan pertanian akan semakin memperburuk kualitas dan kuantitas tanah. Tujuan kegiatan adalah mengidentifikasi fisika tanah lahan pertanian yang digunakan secara intensif di Sumatera Barat. Penelitian ini mengambil sampel di lokasi yang representatif pada Bulan Januari 2022. Tanah yang diambil dilakukan secara acak, pada masing-masing lokasi di Sumatera Barat antara lain, Padang Pariaman; Pesisir Selatan; Kabupaten Solok; Dharmasraya; dan Kota Padang. Penelitian ini menggunakan metoda deskripsi dan survey dan mengambil sampel pada lokasi yang representatif. Tanah yang halus digunakan untuk penetapan Bulk density, Particle density, total ruang pori dan pH tanah. Kerapatan isi Histosol di Lubuk Alung Kabupaten Padang Pariaman berkisar 0,5-0,78 g cm-3, Ultisol berkisar 1,04-1,4 g cm-3, Andisol berkisar 0,88 g cm-3; Alfisol sebesar 0,9 g cm-3; dan Inceptisol berkisar 0,85-0,96 g cm-3. Tanah yang berada di Gunung Pangilun; Lubuk Minturun Padang dan Lagan Gadang Hilir (Pessisir Selatan), perlu dibenahi karena rentang kelembaban tanah dalam kondisi air tersedia sangat sempit atau sedikit akibatnya tanaman mudah kekeringan, dan butuh irigasi atau penyiraman yang berkala. Histosol di Punggasan Pesisir Selatan, memiliki total ruang pori mencapai 63,83%. Tanah yang berada di beberapa wilayah di Sumatera Barat memiliki pH 5,05, meliputi Padang Pariaman, Pesisir Selatan, Kabupaten Solok dan Kota Padang. Kawasan Gunung Pangilun memiliki pH 6,43 memiliki pH terbaik dibandingkan semua pH dari berbagai jenis tanah dari yang diukur.
Faktor Yang Mempengaruhi Terjadinya Kekurangan Energi Kronik Pada Ibu Hamil
Authors: Mulyani Endah , Yuliati Luluk Yuliati , Handajani Diani Octaviyanti , Putri Diska Winda , Aisiyah Finnariqotul , Lindasari Dwi 
Published: July 2023

ABSTRACTBackground of StudyChronic Energy Deficiency is a state of malnutrition in which the mother experiences a prolonged lack of food. Pregnant women are a nutritionally vulnerable group because maternal intake during pregnancy greatly affects the growth and development of the fetus. The problem of Chronic Energy Deficiency in pregnant women is an indirect cause of maternal death because Chronic Energy Deficiency increases the occurrence of complications of pregnancy and childbirth . This study aims to examine the effect of maternal characteristics (age, parity, education and occupation), family income, consumption patterns and body mass index before pregnancy on the incidence of Chronic Energy Deficiency in pregnant women.Methods : This study uses an analytic type with a cross sectional approach. The sample of this study was 54 pregnant women in Leran village, Manyar district, Gresik regency usedÂ multiple logistic regression.Results : Based on bivariate anlysis, level education variable (p=0.023), level of maternal knowledge (p=0.012), family income variable (p=0.036), consumption Â pattern variable (p=0.003) and maternal BMI before pregnancy variable (p=0.003) were associated to the incidence of Â Chronic Energy Deficiency Â on pregnant women inÂ Leran village, Manyar district, Gresik regencyConclusion : Chronic Energy Deficiency in pregnant women is caused by various factors so that the steps that can be taken are to provide assistance as an effort to deal with the condition of pregnant womenKeywords : Chronic Energy Deficiency, Malnutrition, Pregnant Women
Analisis Aspek Fungsional Kesiapsiagaan Bencana di Rumah Sakit Umum Rajawali Citra 2021
Authors: Putra Hodiri Adi 
Published: July 2023

ABSTRACTÂ Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Background of Study : Hospital preparedness for disasters is reflected in the structure of the disaster team. Measurement of preparedness is needed for the identification and classification of disaster management. This study aims to analyze the functional aspects of disaster preparedness at the Rajawali Citra General Hospital. Methods : The research is a qualitative descriptive using purposive sampling method. The sample is an employee who has a position in hospital disaster management. The validity of the data used triangulation of sources and methods while the data analysis used content analysis after being processed with open code. The measurement instrument used the 2015 Hospital Safety Index criteria. Results : The results showed that the hospital disaster management team had officially been formed by the Rajawali Citra General Hospital to respond to disaster situations. As a disaster preparedness hospital, it is reflected in the structure of the disaster management team that has been mutually agreed upon. The hospital disaster team has carried out disaster training to improve knowledge and skills, the hospital's Emergency Operations Center is in a safe and easily accessible and protected area, equipped with an evacuation route map, the hospital has collaborated with external disaster management teams such as the local government. fire and local disaster management agencies. Action cards for all personnel already exist, including disaster vest uniforms.Conclusion : Based on the results of the study, it can be concluded that the hospital has implemented functional aspects of disaster preparedness, this can be seen from the existence of a disaster committee, having disaster training, having an emergency operations center, collaborating with regional disaster management agencies and having a disaster identity card.Â Keywords : Functional Aspects, Preparedness, Disaster
Pengetahuan Dan Sikap Terhadap Perilaku Pengelolaan Sampah 3R (Reduce, Reuse Dan Recycle) Di Desa Potorono Banguntapan Bantul Daerah Istimewa Yogyakarta
Authors: Dwibarto Rendita , Saâ€™adah Sri Maulidiyatus 
Published: July 2023

ABSTRACTÂ Background of Study : Waste Garbage is one of the problems that exist in society where the impact will change people's behavior patterns. The community of Potorono Village, Banguntapan Bantul DIY has a problem with the impact of waste waste, namely the impact of waste disposal in the environment on people's behavior patterns. 3R waste management, through interviews with one of the waste bank informants, are not satisfied with the waste bank services, the community is not fully aware of waste disposal, difficulties in processing waste due to costs, lack of assistance and funds are still few, less people to make banks effective trash in the area. The purpose of this study was to determine the effect of knowledge and attitudes on waste management behavior with 3R in Potorono Banguntapan Village, Bantul DIY. Methods : This study uses an observational quantitative design with a cross-sectional approach. Data collection techniques used in this study were observation, interviews, questionnaires and documentation. And using the Total Sampling technique. The sample consisted of 30 samples of P2WKSS mothers. Data were analyzed using Chi Square.Results : The results in this study there is a significant correlation between knowledge and behavior with p value = 0.01 <0.05, and there is also a significant correlation between attitudes and behavior with p value = 0.01 <0, 05. Conclusion : The conclusion in the explanation is that P2WKSS women in knowledge and attitudes towards waste management with 3R are still not good. Meanwhile, the behavior of P2WKSS women towards waste management with 3R in Mertosanan Kulon Hamlet, Potorono Village Banguntapan Bantul DIY is balanced between good and bad. And after being given counseling, hopefully the insights of P2WKSS women will be wider.Â Keywords: Knowledge, Attitude, Behavior, Waste Management.
Faktor Sosial Ekonomi dan Pengetahuan dengan Status Gizi Balita di Desa Srimartani Kecamatan Piyungan Bantul
Authors: Adnani Hariza , Ismawati Ismawati 
Published: July 2023

Background of Study: Based on the data from Health Office Bantul District, in 2019 there were toddlers who have malnutrition of 6.3264% and 0.38% of poor nutrition based on Monitoring Status Nutritional (MSN) recapitulation in the Piyungan Health Center. Srimatani village was the highest village who has malnutrition, there were 55 toddlers. The purpose of this study is to determine the socio-economic factors associated with the toddler nutritional status in Srimartani Village, Piyungan District, Bantul Regency.Methods: This type of research was an observational study with a cross-sectional approach. The population in this study were 94 toddlers in Srimartani Village, Piyungan District, Bantul Regency. The sampling technique used total sampling. Analyzing data used chi square test.Results:. Socio-economic factors related to the nutritional status of toddlers in Srimartani Village, Piyungan District, Bantul Regency were education (Ï‡2 value = 45,277,Asymp sig = 0.00), employmentÂ status (Ï‡2 value = 84,298 Asymp sig = 0.00); and income with nutritional status of toodler (Ï‡2 value value = 24,851,Astmp sig = 0.00). There was no correlation between knowledge and nutritional status of toodler.Conclusion: Socio-economic factors related to the nutritional status of toddlers in Srimartani Village, Piyungan District, Bantul Regency are education, employment statusÂ and income; Knowledge of parents of toddlers is related to the nutritional status of toddlers in Srimartani Village, Piyungan District, Bantul Regency.Keywords:Â nutritional status, knowledge, socio-economic factors
Method of creation of power sources for home appliances under constraints of limited resources
Authors: Perepelitsyn Artem , Tetskyi Artem 
Published: July 2023

The subject of study in this article is the voltage ranges, methods, and tools for prototyping independent sources of power supply and artificial lighting for home appliances with reuse of only widespread components. The goal is to improve the efficiency of the creation and use of independent power supply sources for home appliances. Task: to analyze the history of the development of voltage standards for households; analyze existing autonomous power sources and types of batteries; analyze different loads; find rational voltage ranges based on fundamental values; analyze charge control and balancing circuits for lithium-based batteries; propose the technique of prototyping independent sources of power supply based on reused lithium-ion (Li-ion) accumulators; provide an example of the practical application of the results of research. According to the tasks, the following results were obtained. The evolution of voltage standards of electrical supply networks is analyzed. Types of autonomous power supplies, including pure sine versions, are discussed. The analysis of batteries for autonomous power sources of different chemical compositions is performed. It is proposed to use the water analogy of current and area as an analogy of battery capacity for visual representation of electrical processes. Models of constant current consumption and constant power consumption are considered. It is proposed to reduce the internal resistance of the battery assembly by parallel connection of the reused lithium-ion accumulators. Correspondence of voltage ranges of sequential connection of lithium-ion cells to ensure compatibility with existing devices is investigated. Rational parameters of voltage ranges to ensure compatibility of lithium-ion and acid accumulators with the ability to charge directly from solar panels without a charge controller are found. Charge controllers, battery management systems (BMS), and battery balancing circuits are analyzed. A set of steps for reuse of lithium-ion accumulators for the creation of autonomous power sources is proposed. Conclusions. The main contribution of this research is the proposed method of creation of power supply and interior lighting based on the reuse of accumulators without additional components. The discovered and proposed magic numbers of 3, 5, 7, 9, 11 and 13 for series connection of lithium-ion cells allows to obtain the equivalent of standard voltage ranges of 12 V, 19 V, 27 V, 36 V, 42 V and 48 V. The proposed technique of adjusting the voltage of the passive balancer allows adding 4.5 % to the capacity of the battery assembly. The described solutions allow to build the completely scalable autonomous low-voltage electrical supply network with the ability to charge directly from solar panels without expensive charge controllers.