bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring factors influencing skin incision to the delivery time and their impact on neonatal outcomes among emergency cesarean deliveries indicated for non-reassured fetal heart rate status
Authors: Zewdu Dereje , Tantu Temesgen , Degemu Fikretsion , Hawlet Michael , Dejene Nitsuh , Asefa Emebet 
Published: September 2023

BackgroundThe time interval between skin incision and delivery (S-D) is crucial in determining neonatal outcome; however, little is known about the influencing factors and their impact on neonatal outcomes, particularly among emergency cesarean deliveries (ECD) indicated for fetal distress. This study investigated the factors influencing S-D time and their effects on neonatal outcomes among mothers who underwent ECD for non-reassured fetal heart rate status.MethodsThis retrospective cohort study involved 426 mother-infant pairs over four years. We retrieved data from the medical records, including baseline characteristics, perioperative data, and neonatal outcomes. Using multivariable logistic regression analysis, adjusted odd ratios, and a 95% confidence interval, potential factors influencing S-D time and their impacts on neonatal outcomes were assessed. A p-value of less than 0.05 was considered statistically significant.ResultsFactors independently associated with longer S-D time (&gt;8 min) were mothers who had previous CD (AOR 5.9: 95% CI 2.2–16.1), obese mothers (AOR 6.2: 95% CI 1.6–24.5), and the second stage of labor (AOR 5.3: 95% CI 2.4–11.7). Adverse neonatal outcomes, including a 5th minute Apgar score of less than 7, the need for NICU admission, and neonatal death, were significantly higher in the longer S-D time interval [47.7% vs. 8.9%; p-value 0.001], [21.9% vs. 9.1%; p-value 0.001], and [32% vs. 11.8%; p-value = 0.004], respectively. Obese mothers and the second stage of labor, but not previous CD, adversely impact neonatal outcomes.ConclusionLonger S-D times are significantly associated with adverse neonatal outcomes. Factors that prolong the time interval between skin incision and delivery may or may not necessarily be associated with adverse neonatal outcomes. Considering surgical techniques that shorten the incision-delivery time and preparation for advanced neonatal care for risky subjects would help reduce detrimental neonatal consequences.
Evaluation of anti-cancer effects of carnosine and melittin-loaded niosomes in MCF-7 and MDA-MB-231 breast cancer cells
Authors: Hussein Mohamed M. A. , Abdelfattah-Hassan Ahmed , Eldoumani Haitham , Essawi Walaa M. , Alsahli Tariq G. , Alharbi Khalid Saad , Alzarea Sami I. , Al-Hejaili Hassan Y. , Gaafar Sara F. 
Published: September 2023

Background: We investigated the anti-cancer effect of carnosine-loaded niosomes (Car-NIO) and melittin-loaded niosomes (Mel-NIO) with olaparib in breast cancer cell lines (MCF-7 and MDA-MB-231).Methods: The thin film method was used for preparing the niosomes and characterized in terms of morphology, size, and polydispersity index (PDI). We further evaluated the impact of these peptides on breast cancer cells viability, RT-qPCR assays, malondialdehyde (MDA) activity, and cell cycle progression, to determine if these are linked to carnosine and melittin’s anti-proliferative properties.Results: Car-NIO and Mel-NIO in vitro study inhibited cancer cell viability. They have also upregulated the expression of protein 53 (P53), BCL2-Associated X Protein (Bax), caspase-9, caspase-3, programmed cell death 4 (PDCD4), and Forkhead box O3 (FOXO3), while downregulated the expression of B-cell lymphoma 2 (Bcl2), poly (ADP-ribose) polymerase (PARP 1), and MicroRNA-183 (miRNA-183). The MCF-7 cells were arrested at the G2/M phase in Car-NIO, on the other hand, the MDA-MB-231 cells were arrested at the S phase. While the Mel-NIO and olaparib arrested the MCF-7 and MDA-MB-231 cells at the G0/1 phase.Conclusion: Our study successfully declared that Mel-NIO had more anti-cancer effects than Car-NIO in both MCF-7 and MDA-MB-231 breast cancer cells.
Association between angiotensin-converting enzyme inhibitor-induced cough and the risk of lung cancer: a Mendelian randomization study
Authors: Yao Taikang , Wu Zhenchao , Wang Zilu , Chen Liting , Liu Beibei , Lu Ming , Shen Ning 
Published: September 2023

Background: Observational studies and meta-analyses have demonstrated a positive correlation between the use of angiotensin-converting enzyme inhibitors (ACEIs) and lung cancer. However, the findings remain controversial; furthermore, the relationship between ACEI-induced cough and lung cancer development remains unknown. We used Mendelian randomization (MR) to verify the association between ACEI use, ACEI-induced cough, and the risk of lung cancer.Methods: We performed a two-sample MR analysis to determine the unconfounded relationships between ACE inhibition, which mimics the effects of ACEIs, and genetic proxies for ACEI-induced cough and lung cancer. Single nucleotide polymorphisms that imitate ACE receptors and ACEI-induced cough were collected and integrated into a meta-analysis of existing genome-wide association studies for various lung cancers. The relationship was quantified using inverse variance weighting, weighted median, and MR-Egger methods.Results: A statistically significant association was observed between ACE inhibition and the risk of small cell lung cancer for Europeans (excluding rs118121655/rs80311894). Associations were identified between ACEI-induced cough and the risk of lung cancer for Europeans, although not for Asians, and between ACEI-induced cough and lung adenocarcinoma (excluding rs360206).Conclusion: Our findings reveal a relationship between ACE inhibition and lung cancer development, as well as a significant association between ACEI-induced cough and a higher risk of lung cancer for Europeans. Patients with hypertension who experience dry cough as a side effect of ACEI use should consider switching to an alternative antihypertensive treatment.
The impact of verbal encouragement during the repeated agility speed training on internal intensity, mood state, and physical enjoyment in youth soccer players
Authors: Selmi Okba , Jelleli Hilmi , Bouali Souheir , Aydi Bilel , Hindawi Omar , Muscella Antonella , Bouassida Anissa , Weiss Katja , Knechtle Beat 
Published: September 2023

ObjectiveVerbal encouragement (VE) can be used by coaches to boost morale and commitment during training exercises. This investigation aimed to study the impacts of VE given by coaches on the physiological aspects, players' internal intensity, mood, and perceived enjoyment of youth soccer players during repeated agility speed training (RAS).MethodsA total of 17 male youth soccer players (mean ± SD; age: 13.8 ± 0.4 years; body mass: 59.1 ± 6.7 kg; height: 170.0 ± 6.2 cm; training experience: 5.1 ± 0.7 years) participated, in a randomized order, in two experimental training sessions that consisted of a RAS (i.e., the Illinois course) either with VE (RAS-E) or without VE (RAS-NE), with a 7-day interval between the testing sessions. Heart rate (HR) was registered throughout the exercise. The rating of perceived exertion, blood lactate concentration [La], and perceived enjoyment were measured after each training session. The mood state was recorded before and after each protocol.ResultsHR mean (Cohen's coefficient d = 0.45, small), %HRmax (d = 0.37, small), HR peak (d = 0.66, moderate), [La] (d = 0.56, small), and the PACES score (d = 2.8, very large) were higher in RAS-E compared to RAS-NE (all, P &lt; 0.001). Compared to the RAS-E trial, the RAS-NE trial showed higher fatigue (P &lt; 0.01), tension (P &lt; 0.05), anger (0.05), total mood score (P &lt; 0.001), and lower vigor (P &lt; 0.001).ConclusionCoaches may use VE during RAS to improve psychophysiological responses, mood state, and perceived enjoyment in youth soccer players.
Autonomy and engagement in self-managing organizations: exploring the relations with job crafting, error orientation and person-environment fit
Authors: Doblinger Maria 
Published: September 2023

IntroductionSelf-managing organizations are a novel organizational form that radically decentralizes decision authority to adapt to the volatile business environment and the demands of knowledge work, resulting in new resources and demands for the employees. Therefore, building on the job demands-resources theory and the person-environment fit theory, the associations of self-managing organizations with higher perceived individual autonomy were tested. Additionally, the study investigated how job crafting and handling mistakes related to the relationship between job autonomy and work engagement/satisfaction.MethodA cross-sectional study was conducted to gather data from employees of different self-managing organizations and non-self-managing organizations, and group comparisons and path analyses were applied to test the preregistered hypotheses.ResultsIncreased method and decision autonomy, job crafting behaviors, error management orientation, work engagement, and job satisfaction were found in self-managing organizations. Additionally, a surplus of perceived autonomy compared to the ideal autonomy was associated with lower work engagement and job satisfaction compared to a fit between ideal and perceived autonomy. However, job crafting did not relate to a better fit between ideal and perceived autonomy. Decision autonomy predicted higher crafting of challenging demands and structural resources for employees with low error strain. Depending on the autonomy type, learning from errors enhanced or reduced the relationship between perceived autonomy and job crafting.DiscussionThis study showed the importance of addressing the higher level of individual autonomy in self-managing organizations and offered starting points for interventions to support employees with handling high autonomy. Reducing error strain but increasing error learning and risking errors could help increase job crafting and work engagement, particularly in self-managing organizations.
The role of motivation and emotions in physical education: understanding academic achievement and the intention to be physically active
Authors: Fierro-Suero Sebastián , Castillo Isabel , Almagro Bartolomé J. , Saénz-López Pedro 
Published: September 2023

IntroductionThis study aims to understand how emotions and motivation influence the academic achievement of physical education (PE) students and their future intention to practice physical activity (PA). Despite the influence on student’s behaviors and the reciprocal associations between motivation and emotion, the number of studies addressing both constructs at the same level is very limited.MethodsA structural equation model was used with 799 students aged 11–17 years (M = 13.16; SD = 1.17).Results and discussionThe results showed that the teacher support of the basic psychological needs (BPN) predicted students’ BPN satisfaction, which in turn predicted their autonomous motivation and positive emotions, and negatively predicted their negative emotions. Finally, autonomous motivation predicted students’ intention to be physically active, whereas academic achievement was predicted by both autonomous motivation and emotions. We conclude that to better understand the consequences of PE classes, it is necessary to consider both constructs.
Seroprevalence survey of SARS-CoV-2, community behaviors, and practices in Kansanshi and Kalumbila mining towns
Authors: Mumba Temple Kahilu , Merwe Kylie Van Der , Divall Mark , Mwangilwa Kelvin , Kayeyi Nkomba 
Published: September 2023

BackgroundCoronavirus disease 2019 (SARS-CoV-2) was declared a global pandemic by WHO after it spreads quickly around the world from its source city in Wuhan. Africa has some of the lowest documented SARS-CoV-2 incidences globally, with over 9 million confirmed cases as of December 2022. This may be due to efficient mitigation, outbreak response, or demographic traits. Surveillance capability may have suffered as nations changed funding, regulations, and testing plans. Therefore, this study was to document the prevalence of SARS-CoV-2, its characteristics, and the socio-economic characteristics in the two mining districts of Solwezi and Kalumbila of Zambia.MethodsBetween 28 March and 26 April 2021, a cross-sectional cluster-sample survey of households in two mining districts of Zambia was conducted. Twenty standard enumeration areas (SEAs) were randomly selected in Kansanshi (17 SEA) and Kalumbila (3 SEA) from a total of 67 SEA that encompass the two mines. Members of households aged &lt;5 years were not eligible to participate in the survey. All participants that consented to participate in the interview were also asked to consent to test for SARS-CoV-2 infection using a rapid diagnostic test (RDT), which tested for recent infection and past exposure to the virus (IgM and IgG, respectively).ResultOut of the total sample of 3,047 that were present for the interview, 622 of them agreed to test for COVID-19. Of the total that tested for SARS-CoV-2, 2.6% were IgM positive while 9.0% were IgG positive. Despite the above results, 1,586 participants that agreed to the interview indicated a low self-risk assessment of getting COVID-19 (46.5%) or someone (45.5%). On the public health measures, participants who did handwashing more than usual (65.0%), not hand sanitizing more than usual (69.0%), not disinfecting surfaces in their households than usual (87.5%), not avoiding drinking from bars or nightclubs (90.6%), and not wearing a mask when out in public places (71.1%). In the logistic multivariable model, participants with age 24 years and above (AOR = 2.94; 95% CI = 1.10, 7.81) and having experienced symptoms of SARS-CoV-2 (AOR = 2.60; 95% CI: 1.33, 5.05) had a significant effect on testing positive for SARS-CoV-2.ConclusionAlthough the results showed that active COVID-19 prevalence in Solwezi and Kalumbila communities surrounding the two mines was low, exposure to infection was five times high. Government and mining firms should continue to sensitize the community members on the preventive measures of COVID-19 and continue with community testing so that all those positive but without symptoms can self-isolate and those with symptoms and sick can be admitted to the hospital.
Co-designing an interactive artificial intelligent system with post-stroke patients and caregivers to augment the lost abilities and improve their quality of life: a human-centric approach
Authors: Ventura Sara , Ottoboni Giovanni , Lullini Giada , Chattat Rabih , Simoncini Laura , Magni Elisabetta , Piperno Roberto , La Porta Fabio , Tessari Alessia 
Published: September 2023

ObjectivesThe motor disability due to stroke compromises the autonomy of patients and caregivers. To support autonomy and other personal and social needs, trustworthy, multifunctional, adaptive, and interactive assistive devices represent optimal solutions. To fulfill this aim, an artificial intelligence system named MAIA would aim to interpret users’ intentions and translate them into actions performed by assistive devices. Analyzing their perspectives is essential to develop the MAIA system operating in harmony with patients’ and caregivers’ needs as much as possible.MethodsPost-stroke patients and caregivers were interviewed to explore the impact of motor disability on their lives, previous experiences with assistive technologies, opinions, and attitudes about MAIA and their needs. Interview transcripts were analyzed using inductive thematic analysis.ResultsSixteen interviews were conducted with 12 post-stroke patients and four caregivers. Three themes emerged: (1) Needs to be satisfied, (2) MAIA technology acceptance, and (3) Perceived trustfulness. Overall, patients are seeking rehabilitative technology, contrary to caregivers needing assistive technology to help them daily. An easy-to-use and ergonomic technology is preferable. However, a few participants trust a system based on artificial intelligence.ConclusionAn interactive artificial intelligence technology could help post-stroke patients and their caregivers to restore motor autonomy. The insights from participants to develop the system depends on their motor ability and the role of patients or caregiver. Although technology grows exponentially, more efforts are needed to strengthen people’s trust in advanced technology.
The association between quality of life and subjective wellbeing among older adults based on canonical correlation analysis
Authors: Liu Huanting , Gan Qihui , Tan Jianfeng , Sun Xiaoyuan , Liu Yuxi , Wan Chonghua 
Published: September 2023

IntroductionThe study explored the relationship between subjective well-being and the quality of life among older adults. It highlights the importance of understanding how these factors are interconnected in the context of an aging population.MethodsDescriptive statistics were used to analyze the scores of general demographic characteristics, subjective wellbeing and quality of life. Simple correlation analysis and canonical correlation analysis were employed to analyze the relationship between subjective wellbeing and quality of life among older adults.ResultsData from 892 older adults were collected. Canonical correlation analysis revealed four pairs of canonical variables, with the first four pairs of canonical correlation coefficients all being statistically significant (0.695, 0.179, 0.147, 0.121) (p &lt; 0.05), and the first pair of canonical variables explaining 93.03% of the information content. From the canonical loading coefficients, Vitality and mental health contributed the most to the quality of life (U1) canonical variable. The canonical variable V1, which corresponded to subjective wellbeing, was reflected by a combination of positive affect, negative affect, positive experience and negative experience. X1 (physical functioning), X2 (role-physical), X3 (bodily pain), X4 (general health), X5 (vitality), X6 (social functioning), X7 (role-emotional) and X8 (mental health) were positively correlated with Y1 (positive affect) and Y3 (positive experience), negatively correlated with Y2 (negative affect) and Y4 (negative experience). Cross-loadings revealed that physical functioning, bodily pain, general health, vitality, social functioning and mental health were the main factors reflecting the subjective wellbeing of older adults.DiscussionAs quality of life among older adults was highly correlated with subjective wellbeing, appropriate measures should be taken to account for individual characteristics of older adults, and various factors should be integrated to improve their subjective wellbeing.
The impact of using community home-based elderly care services on older adults’ self-reported health: fresh evidence from China
Authors: He Yang , Wei Baojian , Li Yushang 
Published: September 2023

BackgroundThe rapid population aging in China, characterized by a higher prevalence of illnesses, earlier onset of diseases, and longer durations of living with ailments, substantially engenders challenges within the domain of older adults’ healthcare. Community home-based elderly care services (CHECS) are a feasible solution to solve the problem of older adults’ care and protect older adults’ health. The aim of this study is to investigate the relationship, heterogeneity effects and influential mechanisms between older adults’ use of CHECS and their self- reported health.MethodsThe study employs the Instrumental Variable technique and empirically investigates the relationship, heterogeneity effects and influential mechanisms between older adults using CHECS and their self-reported health using data from the China Longitudinal Aging Social Survey from 2018.ResultsThe findings indicate, firstly, that using CHECS considerably improves older adults’ self-reported health. Secondly, the heterogeneity test reveals that the effect is more pronounced for older adults who are under the age of 80, have functional disabilities, are free of chronic diseases, have never attended school, reside in lower-income households, are single, rarely interact with their children, and live in central urban or city/county regions. Thirdly, the mechanism test reveals that the “social network effect” and “family care effect” are the key influence channels of using CHECS.ConclusionAn empirical foundation for the policy reform of community home-based care for seniors is provided by this study with the limitations to discuss the other socioeconomic aspects such as government health expenditure and discuss the specific services aspects such as health care. The findings carry substantial implications for improving the health of older individuals and provide suggestions for establishing a socialized aged care system in China.
Stochastic evolutionary game analysis of food cooperation among countries along the Belt and Road from the perspective of food security
Authors: Qinghua Mao , Linyao Xu , Qilong Sun , Mengxin Guo 
Published: September 2023

IntroductionIn recent years, the combination of the public health crisis and the climate crisis has greatly weakened the resilience of food systems. The Belt and Road food cooperation will make outstanding contributions to consolidate food security and reduce global poverty in countries along the Belt and Road.MethodsThis paper constructs a three-party stochastic evolutionary game model from the perspective of food security, distinguishes the difference between large and small countries by calculating the cereal self-sufficiency rate, which studies the cooperation strategy with the Belt and Road cereal large countries, cereal small countries and regulatory committees as the object. In addition, we introduce the Gaussian white noise characteristics to characterize the stochastic disturbance of the game system. Then we combine the mathematical derivation of the stochastic evolutionary game analysis with the simulation method, examine the effect of the stochastic disturbance factors on the cooperation, and find out the factors that affect the cooperation. And finally verifies the model and proves the reasonableness and practicability of the model.ResultsThe stochastic evolutionary game model analyzes the interaction of stochastic disturbance and influencing factors from a dynamic perspective, and the stability of evolution is related to the strength of Gaussian white noise. The level of effort of large cereal countries and the incentives of regulatory committees can have a positive impact, but high income in small cereal countries can lead to instability in the strategic choices of other players.DiscussionTaking the countries along the Belt and Road as the research object, Gaussian white noise is introduced to describe the stochastic external environment, discriminate the stability of the game system through stochastic differential equations, and analyze the influencing factors of the dynamic behavioral strategies of the parties in combination with simulation methods. To improve the capacity of national food security governance and help improve the resilience of the world food system.