bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep Learning and Metaheuristics based Cyber Threat Detection in Internet of Things Enabled Smart City Environment
Authors: Das Sonali , Manchala Yugandhar , Rout Saroja Kumar , Panda Sujit kumar 
Published: July 2023

Abstract
Recently, the extensive use of Internet of Things (IoT) applications has a stronger impact and greater contribution to the development of the smart city. A smart city (SC) uses IoT-based technologies, applications, and communications for maximizing operational efficacy and improving the service quality of providers and the living standard of people. With the development of SC networks, there also comes the augmented menace of cybersecurity attacks and threats. IoT gadgets within an SC network were linked to sensors connected to huge cloud servers and are vulnerable to malicious threats and attacks. Therefore, it is significant to formulate techniques for preventing such assaults and protecting IoT gadgets from failures. This article develops a new transient search algorithm with optimal stacked sparse autoencoder (TSA-OSSAE) based cyber threat detection in IoT-enabled SC applications. The presented TSA-OSSAE technique majorly focuses on the recognition of cyber threats to attain security in the SC. To attain this, the projected TSA-OSSAE system follows TSA based feature selection approach to reduce computational complexity. Besides, the TSA-OSSAE technique applies the SSAE model for cyber threat detection. At last, the hyperparameters of the SSAE approach are optimally chosen by utilizing of multi-versus optimizer (MVO) algorithm. The experimental result analysis of the TSA-OSSAE technique was performed by using the TON_IoT telemetry database. The simulation outcomes signify the promising performance of the TSA-OSSAE methodology over other existing techniques.
A New Assessment System of Osteoporotic Vertebral Compression Fractures: A Retrospective Study
Authors: Jin Cong , Zhen Jiewen , He Wei , Han Weiqi , He Lei 
Published: July 2023

Abstract
Background
We have developed a new scoring system that specifically designed for osteoporotic vertebral compression fractures (OVCFs) to guide treatment selection. This system evaluates four aspects: fracture type, fracture morphology, MRI signal changes, and bone mineral density.
Methods
From March 2016 to March 2021, we conducted a retrospective study of radiographic and clinical data from 208 patients who underwent conservative treatment for OVCFs. Based on the new assessment system of osteoporotic vertebral compression fractures (NASOVCF) scores, the patients were divided into low (48 cases), medium (108 cases), and high (52 cases) score groups. We compared the visual analog scale (VAS), Oswestry Disability Index (ODI) scores, vertebral height loss, kyphosis angle, and bone union rate among the three groups. Logistic regression analysis was used to determine the relationship between bone non-union and independent variables.
Results
The low-score group showed significantly lower VAS and ODI scores both before treatment and at the follow-up compared to the medium-score and high-score groups (P < 0.05). Additionally, the low-score group had significantly lower vertebral height loss and kyphosis angle differences compared to the medium-score and high-score groups. The bone union rate in the low-score group was 97.9%, which was significantly higher than the rates of 75% in the medium-score group and 32.7% in the high-score group. The high-score group had a significantly higher risk of non-union compared to the low-score group (OR = 88.78; P = 0.001) and the medium-score group (OR = 15.67; P = 0.001). Additionally, female gender (OR = 3.20, P = 0.014), ODI at pre-treatment (OR = 1.11, P = 0.009), and NASOVCF score (OR = 2.59, P = 0.000) were identified as independent risk factors for bone non-union.
Conclusions
Based on the NASOVCF scoring system, the low-score group showed superior outcomes in terms of pain relief, functional improvement, prevention of vertebral height loss and worsening spinal kyphosis, as well as a higher bone union rate, compared to the medium-score and high-score groups. Therefore, conservative treatment is recommended for OVCF patients with a score of 3 or less, while surgical treatment is recommended for patients with a score of 7 or higher.
Terahertz time-domain spectroscopy as a novel tool for crystallographic analysis in cellulose: tracking lattice changes following physical treatments
Authors: Wang Han , Aoki Dan , Teramoto Yoshikuni , Tsuchikawa Satoru , Inagaki Tetsuya 
Published: July 2023

Abstract
The author's series of studies aimed to explore the potential of terahertz time-domain spectroscopy (THz-TDS) in cellulose crystallography research, as THz radiation can detect most intermolecular vibrations and respond to the lattice phonons. In this study, we used THz-TDS and X-ray powder diffraction (XRD) to meticulously trace the changes in the four types of cellulose after ball milling. The most captivating observation was the crystal transition from cellulose I to cellulose II (cellulose I treated with 10% NaOH), demonstrating reduced crystallinity but an increased conversion rate to cellulose II after ball milling. Moreover, we used scanning electron microscopy to observe the morphological changes of the treated cellulose samples after ball milling in detail, and gel permeation chromatography was used to determine the molecular weight, probing the correlation between morphological and molecular weight changes with the THz 2nd derivative absorption spectrum and the XRD pattern.
Using trials of caloric restriction and bariatric surgery to explore the effects of adiposity on the circulating proteome
Authors: Goudswaard Lucy , Smith Madeleine , Hughes David , Taylor Roy , Lean Michael , Sattar Naveed , Welsh Paul , McConnachie Alex , Group NIHR By-Band-Sleeve Trial Management , Suhre Karsten , Zaghlool Shaza , Hers Ingeborg , Timpson Nicholas , Corbin Laura 
Published: July 2023

Abstract
Thousands of proteins circulate in the bloodstream; identifying those which associate with weight and intervention-induced weight loss may help explain mechanisms of diseases associated with weight. We aimed to identify consistent protein signatures of weight loss across independent studies capturing changes in body mass index (BMI). We analysed proteomic data from studies implementing caloric restriction (Diabetes Remission Clinical trial (DiRECT)) and bariatric surgery (By-Band-Sleeve), using SomaLogic and Olink Explore1536 technologies, respectively. Linear mixed models were used to estimate the effect of the interventions on circulating proteins. 23 proteins were altered in a consistent direction after both bariatric surgery and caloric restriction. We integrated Mendelian randomisation (MR) estimates of BMI effect which provided further corroborative evidence for a causal role of BMI in regulating the levels of six proteins including alcohol dehydrogenase-4, nogo receptor and interleukin-1 receptor antagonist protein. Further study into the role of these proteins in disease is warranted.
Exploring mangrove adaptability in Laguna de Términos: implications for biological conservation through ecological measures and GIS-based protection zones (Campeche, Mexico)
Authors: Halecki Wiktor , Bedla Dawid , Hernández Nuria Aide López , Hernández Vicente Espinosa 
Published: July 2023

Abstract
To safeguard the ecosystems and species in megadiverse countries such as Mexico, ecological measures are imperative. This study examined the adaptability of mangroves to environmental and anthropogenic changes. As this area comprises a multitude of ecologically consequential abiotic gradients, it represents a valuable resource for understanding the ramifications of worldwide climate change. Nevertheless, gauging the coastal biodiversity in the Gulf of Mexico presents a formidable challenge. The primary aim of this research was to evaluate the factors that contribute to the ongoing chronic changes within and around mangroves. By analyzing satellite images from 1981 to 2020, we investigated the decadal variations in mangrove coverage across the Yucatán Peninsula in the western Caribbean Sea. The research area obtained a high ecological index score of 0.71, indicating its considerable natural value. Moreover, an anthropogenic index score of 0.46 was observed on the map, indicating the impact of human activities on the area. To connect and preserve biodiversity in the area, we proposed a GIS-based spatial biological corridor technique (protection zones). Urgent action is necessary to promote better forest management and restoration that can provide opportunities for climate change adaptation for mangrove and neighboring ecosystems.
Inequality of Opportunity and Early Childhood Development in Togo
Authors: PELENGUEI Essohanam , PILO Mikémina 
Published: July 2023

Abstract
This paper aims to analyze the effect of inequality of opportunity on early childhood development in Togo. To achieve this objective, we use a logit model to obtain the conditional probabilities of the study circumstances. Based on these probabilities, we construct dissimilarity indices with the parametric approach and then apply Shapley decomposition using data from the Multiple Indicator Cluster Survey (MICS) conducted in Togo in 2017. The results obtained show that inequalities in opportunities slow early childhood development. The Shapley decomposition reveals that region of residence, ownership of agricultural land and mother's education contribute most to inequalities in early childhood development dimensions at 57.58%, 25.50% and 28.77%, respectively. Additionally, the return to an equal situation between children characterized by good health, better nutrition and good social and emotional cognitive development and those in poor condition is conditioned by the reallocation of 12.4% of the inequalities of the first group of children to the second group. Strengthening the coordination of agricultural activities and the provision of safe water to rural households is essential to improve the level of the early childhood development indicator.
JEL Classification: D30, D63, I14, I15
Design and Analysis of a Crescent-Shaped MIMO Antenna for 5G Millimeter Wave Applications
Authors: Sghaier Nizar , Belkadi Anouar , Hassine Islem Ben , Latrach Lassaad , Gharsallah Ali 
Published: July 2023

Abstract
The present study introduces an innovative MIMO (multiple input multiple output) antenna for fifth generation (5G) wireless applications operating in the millimeter wave (mm-Wave) band. The antenna is designed using a crescent concept on three superposed balls, similar to the symbol on top of a mosque minaret. The proposed design is developed on a 20×10 mm2 FR4 substrate with a dielectric constant of 4.4 and a tangent loss of 0.002. The frequency range of the proposed antenna is between 27.3 to 28.9 GHz, and it offers excellent isolation (> 25 dB). The authors have conducted a parametric analysis and surface current distribution to optimize the parameters and analyze the coupling between the elements. The performance of the design is evaluated based on various criteria such as efficiency (> 95%), peak gain (> 14 dBi), and radiation patterns (E and H fields). The diversity parameters (ECC, DG and CCL) have been calculated and verified, and the results of the fabricated prototype have been compared to the simulated results, which are found to be in good agreement.
The impact of Royal Jelly on In-Vitro Fertilization outcome in low ovarian reserve women, a randomized clinical trial
Authors: Jafari Afrooz , Nemati Maryam , Lorigooini Zahra , Yazdani Mohammadjavad , Salehi Mahsa , Kheiri Soleiman , Jafari Hamid Reza 
Published: July 2023

Abstract
Background and Aim:
Infertility is one year of regular sexual intercourse without a successful pregnancy. The first and most common form of ART is In-vitro fertilization (IVF). In animal studies, royal jelly is the treatment supplementary to improve fertility. Therefore, this study aims to evaluate the effect of royal jelly on the quality of the ovum and fetus in unsubstantiated women under treatment.
Methods:
The study was a randomized clinical trial on women under 40 years old. 110 infertile women with low ovarian reserve were included in the study. After measuring FSH, LH, TSH, prolactin, anti-mullerian hormone, fasting insulin, and estradiol on the third day of menstruation were divided into two groups: intervention and control groups. The Royal Gel Intervention Group received one gram daily for two months before the IVF Intracytoplasmic Sperm Injection cycle, and the control group received a placebo, similar to the intervention capsule. The quantitative and qualitative amounts of eggs and fetuses were evaluated, and eventually, the clinical pregnancy due to fetal transmission was measured after determining the ratio of immature and atretic ovum to adult ovum in the experimental groups and the fertilization of the fetus. The embryos are qualitatively graded. The results were analyzed and compared by IBM SPSS Statistics 26.0.0.1 software.
Results:
The average age was 30.3 ± 5.7 years. The two groups were not significantly different in age, BMI, AMH (anti-mullerian hormone), FSH, LH, TSH, Prolactin, and estradiol, but were significantly different in the result received from the level of fasting insulin. The consequences for the fetus and the oocytes are not significantly different in the two groups of control. The IVF result was significantly related to the study group, with the percentage of IVF-positive cases in the case group being 66.7% and in the control group at 30%.
Conclusion:
IVF successful outcome is significantly higher in the candidates using Royal Jelly capsule.
Dose 4 You: Dose Division Calculator – A Tool to Reduce Calculation Errors
Authors: Syed Jehath , M Ramesh , M Promod Kumar T , Patil Vikram , Chalasani Sri Harsha 
Published: July 2023

Abstract
Background
Medication dosing calculation errors can cause significant harm to patients, especially in the paediatric population. Crushing tablets for dose division purposes may increase the risk of calculation errors, which can lead to incorrect dosing and compromised patient safety. This study aimed to develop a calculator to eliminate calculation errors associated with dose division.
Methods
Using the Wix platform, a group of pharmacists created a user-friendly webpage "Dose 4 You." To enable accurate dose division calculations, the advanced language model Chat GPT and Visual Studio were used. The tool assists healthcare professionals through a step-by-step process, allowing them to enter the necessary dose and medication requirements. The Dose 4 You web page's reliability and feasibility were assessed using retrospective data and validated questionnaires, including the System Usability Scale (SUS), respectively and a Likert scale-based acceptance questionnaire.
Results
The Dose 4 You website calculated the required amount of powdered tablet to achieve the desired dose with 100% accuracy. The obtained SUS score was 88.38, indicating excellent usability. The average score of all questions for acceptance was found to be 4.7 ± 0.15 indicating a strong agreement on the tool's usefulness and effectiveness.
Conclusion
Dose 4 You is a reliable tool that improves patient safety by streamlining dose calculations and lowering calculation errors. The tool's ease of use, practicality in daily clinical practice, and potential to reduce medication errors are highlighted by the positive perception among healthcare professionals. Dose 4 You's successful implementation demonstrates the power of technology and collaboration in transforming medication administration and improving patient outcomes. Similar innovative solutions to optimize healthcare practices can be explored in future health informatics endeavours.
Lightweight Privacy-Preserving (t, m, n) Multi-Party Computation Based on Secret Sharing in Untrusted Cloud Environments
Authors: Harn Lein , Hsu Chingfang , XIA ZHE 
Published: July 2023

Abstract
The next generation of Internet of Things (IoT) networks and mobile communications (5G IoT networks) has the particularity of being heterogeneous, therefore, it has very strong ability to compute, store, etc. Group-oriented applications demonstrate its potential ability in Untrusted Cloud Environments (UCE). One of the main challenges for secure group-oriented applications (SGA) in UCE is how to secure communication and computation between these heterogeneous devices. Conventional protocols are not suitable for SGA in UCE since multiparty secure computation in this environment requires lightweight communication and computation overhead. Multi-Party Computation (MPC) takes multiple inputs and outputs their sum/product without revealing each individual input. MPC has found ways in electronic voting, electronic auctions, electronic cash schemes, contract signing, etc. Motivated by the first arithmetic MPC protocol (also known as BGW protocol) proposed by Ben-Or et al. based on the secret sharing scheme, in this paper, we give a novel definition, called (t, m, n) MPC, where m is the number of data inputs, t is a threshold and n is the number of shares, which is similar to the definition of a (t, n) secret sharing scheme; but with some additional security requirements. BGW is a (t, m, n) MPC but has following limitations, (1) BGW cannot be used to implement a (m, m, m) MPC; and (2) in computing multiplicative product, BGW needs degree-reduction process which is a communication intensive process. In this paper, we propose a simple and lightweight (m, m, m) MPC which involves only additions/multiplications. Then, we extend our simple (m, m, m) MPC to design a general (t, m, n) MPC. Our proposed MPC is more efficient than BGW since our MPC does not need degree-reduction process. It is really attractive for lightweight privacy-preserving multi-party computation in UCE.
VprBP/DCAF1 triggers melanomagenic gene silencing through histone H2A phosphorylation
Authors: Shin Yonghwan , Kim Sungmin , Liang Gangning , Ulmer Tobias S , An Woojin 
Published: July 2023

Abstract
Background
Melanoma is the most aggressive form of skin cancer arising from pigment-producing melanocytes and is often associated with dysregulation of epigenetic factors targeting histones. VprBP, also known as DCAF1, is a recently identified kinase and plays an important role in downregulating the transcription of tumor suppressor genes as well as increasing the risk for colon and prostate cancers. However, it remains unknown whether VprBP is also involved in triggering the pathogenesis of other types of cancer.
Results
We demonstrate that VprBP is highly expressed and phosphorylates threonine 120 (T120) on histone H2A to drive transcriptional inactivation of growth regulatory genes in melanoma cells. As is the case for its epigenetic function in colon and prostate cancers, VprBP acts to induce gene silencing program dependently of H2AT120 phosphorylation (H2AT120p). The significance of VprBP-mediated H2AT120p is further underscored by the fact that VprBP knockdown- or VprBP inhibitor-induced lockage of H2AT120p mitigates melanoma tumor growth in xenograft models. Moreover, artificial tethering of VprBP wild type, but not VprBP kinase-dead mutant, to its responsive genes is sufficient for achieving an inactive transcriptional state in VprBP-depleted cells, indicating that VprBP drives gene silencing program in an H2AT120p-dependent manner.
Conclusions
Our results establish VprBP-mediated H2AT120p as a key epigenetic signal for melanomagenesis and suggest the therapeutic potential of targeting VprBP kinase activity for effective melanoma treatment.
"Patanjali's Beauty Enigma: Unveiling Women Consumer Perception in the Bareilly Region"
Authors: ALI SHAHEEN EFRAH 
Published: July 2023

Abstract
Purpose –The study aims to identify the factors that influence women consumer behaviour towards Patanjali's cosmetic products, such as brand loyalty, purchase decision-making, and overall satisfaction levels.
Research Methodology – This study used a mixed-method approach, with a sample of 120 women. Quantitative analysis involved 100 responses through structured questionnaires on Google Forms, Descriptive Analysis by using Jamovi Software. Qualitative analysis included interviews with 20 individuals, recorded in Microsoft Excel for frequency distribution and percentages.
Findings – The study concludes that Patanjali's unique marketing strategies and variety of products have presented a significant challenge to many marketers.This study contributes to the understanding of consumer behaviour and brand loyalty in the cosmetic industry.
Research limitations/implications – The study limitations include the sample size and regional focus, suggesting the need for further research in other regions of India.
Practical implications – The study highlights the importance of product quality, reasonable pricing, variety, and natural ingredients, delivering on promises made to consumers, effective marketing strategies, and innovation to retain customers and maintain brand loyalty in the Indian cosmetic market.
Originality/value- The originality and value of this study lie in its exploration of consumer perception and behaviour towards Patanjali cosmetic products in a specific region of India.
Paper Type- Research Paper
A rare case of left atrial appendage aneurysm
Authors: Qin Ke , Teng Peng , Shi Liping , Ma Liang 
Published: July 2023

Abstract
Background
Left atrial appendage aneurysm (LAAA) is a rare cardiac mass. There are usually no specific symptoms, and a few patients see a doctor because of palpitations, chest tightness, dyspnea and other symptoms. At present, only a few cases have been reported. In this case, a rare case of left atrial appendage aneurysm was reported, and the cases reported in previous literature were systematically reviewed.
Case presentation
A 20-year-old male was admitted to our hospital because of the discovery of pericardial cyst by physical examination for 2 years. Echocardiography showed that the cystic dark area of left ventricular lateral wall and anterolateral wall was considered pericardial cyst and mild mitral regurgitation. After improving the relevant examination and excluding contraindications, the resection of benign aneurysm of left atrium was performed under cardiopulmonary bypass. The postoperative pathological results showed that (left atrial appendage) fibrous capsule wall-like tissue with focal lining of flat epithelium, consistent with benign cyst.
Conclusion
Left atrial appendage aneurysms are rare and occult, which are generally found by accidental physical examination. When its location is poor or the volume is too large, there will be symptoms of compression or arrhythmia, thrombosis and other concomitant symptoms. At present, the only and effective radical treatment for LAAA is surgical resection.