bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lenalidomide and dexamethasone maintenance with or without ixazomib, tailored by residual disease status in myeloma
Authors: Rosiñol Laura , Oriol Albert , Ríos Rafael , Blanchard María Jesús , Jarque Isidro , Bargay Joan , Hernández Miguel Teodoro , Cabañas Valentín , Carrillo-Cruz Estrella , Sureda Anna , Martínez-López Joaquín , Krsnik Isabel , González Maria Esther , Casado Luis Felipe , Martí Josep María , Encinas Cristina , de Arriba Felipe , Palomera Luis , Sampol Antonia , González-Montes Yolanda , Cabezudo Elena , Paiva Bruno , Puig Noemí , Cedena María Teresa , de la Cruz Javier , Mateos María-Victoria , San Miguel Jesús , Lahuerta Juan José , Bladé Joan 
Published: July 2023

Abstract
From November 2014 to May 2017, 332 patients homogeneously treated with bortezomib, lenalidomide, and dexamethasone (VRD) induction, autologous stem cell transplant, and VRD consolidation were randomly assigned to receive maintenance therapy with lenalidomide and dexamethasone (RD; 161 patients) vs RD plus ixazomib (IRD; 171 patients). RD consisted of lenalidomide 15 mg/d from days 1 to 21 plus dexamethasone 20 mg/d on days 1 to 4 and 9 to 12 at 4-week intervals, whereas in the IRD arm, oral ixazomib at a dose of 4 mg on days 1, 8, and 15 was added. Therapy for patients with negative measurable residual disease (MRD) after 24 cycles was discontinued, whereas those who tested positive for MRD remained on maintenance with RD for 36 more cycles. After a median follow-up of 69 months from the initiation of maintenance, the progression-free survival (PFS) was similar in both arms, with a 6-year PFS rate of 61.3% and 55.6% for RD and IRD, respectively (hazard ratio, 1.136; 95% confidence interval, 0.809-1.603). After 2 years of maintenance, treatment was discontinued in 163 patients with negative MRD, whereas 63 patients with positive MRD continued with RD therapy. Maintenance discontinuation in patients tested negative for MRD resulted in a low progression rate (17.2% at 4 years), even in patients with high-risk features. In summary, our results show the efficacy of RD maintenance and support the safety of maintenance therapy discontinuation in patients with negative MRD at 2 years. This trial was registered at www.clinicaltrials.gov as #NCT02406144 and at EudraCT as 2014-00055410.
Low-density lipoprotein promotes microvascular thrombosis by enhancing von Willebrand factor self-association
Authors: Chung Dominic W. , Platten Kimsey , Ozawa Koya , Adili Reheman , Pamir Nathalie , Nussdorfer Forrest , St. John Alexander , Ling Minhua , Le Jennie , Harris Jeff , Rhoads Nicole , Wang Yi , Fu Xiaoyun , Chen Junmei , Fazio Sergio , Lindner Jonathan R. , López José A. 
Published: July 2023

Abstract
von Willebrand factor (VWF) mediates primary hemostasis and thrombosis in response to hydrodynamic forces. We previously showed that high shear promoted self-association of VWF into hyperadhesive strands, which can be attenuated by high-density lipoprotein (HDL) and apolipoprotein A-I. In this study, we show that low-density lipoprotein (LDL) binds VWF under shear and enhances self-association. Vortexing VWF in tubes resulted in its loss from the solution and deposition onto tube surfaces, which was prevented by HDL. At a stabilizing HDL concentration of 1.2 mg/mL, increasing concentrations of LDL progressively increased VWF loss, the effect correlating with the LDL-to-HDL ratio and not the absolute concentration of the lipoproteins. Similarly, HDL diminished deposition of VWF in a post-in-channel microfluidic device, whereas LDL increased both the rate and extent of strand deposition, with both purified VWF and plasma. Hypercholesterolemic human plasma also displayed accelerated VWF accumulation in the microfluidic device. The initial rate of accumulation correlated linearly with the LDL-to-HDL ratio. In Adamts13−/− and Adamts13−/−LDLR−/− mice, high LDL levels enhanced VWF and platelet adhesion to the myocardial microvasculature, reducing cardiac perfusion, impairing systolic function, and producing early signs of cardiomyopathy. In wild-type mice, high plasma LDL concentrations also increased the size and persistence of VWF-platelet thrombi in ionophore-treated mesenteric microvessels, exceeding the accumulation seen in similarly treated ADAMTS13-deficient mice that did not receive LDL infusion. We propose that targeting the interaction of VWF with itself and with LDL may improve the course of thrombotic microangiopathies, atherosclerosis, and other disorders with defective microvascular circulation.
Significant photocatalytic decomposition of malachite green dye in aqueous solutions utilizing facilely synthesized barium titanate nanoparticles
Authors: Al-Wasidi Asma S. , Abdelrahman Ehab A. 
Published: July 2023

AbstractThe release of malachite green dye into water sources has detrimental effects on the liver, kidneys, and respiratory system. Additionally, this dye can impede photosynthesis and disrupt the growth and development of plants. As a result, in this study, barium titanate nanoparticles (BaTiO3) were facilely synthesized using the Pechini sol–gel method at 600 °C (abbreviated as EA600) and 800 °C (abbreviated as EA800) for the efficient removal of malachite green dye from aqueous media. The Pechini sol–gel method plays a crucial role in the production of barium titanate nanoparticles due to its simplicity and ability to precisely control the crystallite size. The synthesized barium titanate nanoparticles were characterized by several instruments, such as X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR-TEM), Fourier transform infrared spectroscopy, and a diffuse reflectance spectrophotometer. The XRD analysis confirmed that the mean crystallite size of the EA600 and EA800 samples is 14.83 and 22.27 nm, respectively. Furthermore, the HR-TEM images confirmed that the EA600 and EA800 samples exhibit irregular and polyhedral structures, with mean diameters of 45.19 and 72.83 nm, respectively. Additionally, the synthesized barium titanate nanoparticles were utilized as catalysts for the effective photocatalytic decomposition of malachite green dye in aqueous media. About 99.27 and 93.94% of 100 mL of 25 mg/L malachite green dye solution were decomposed using 0.05 g of the EA600 and EA800 nanoparticles within 80 min, respectively. The effectiveness of synthesized BaTiO3 nanoparticles as catalysts stems from their unique characteristics, including small crystallite sizes, a low rate of hole/electron recombination owing to ferroelectric properties, high chemical stability, and the ability to be regenerated and reused multiple times without any loss in efficiency.
A new line tunneling SiGe/Si iTFET with control gate for leakage suppression and subthreshold swing improvement
Authors: Lin Jyi-Tsong , Weng Shao-Cheng 
Published: July 2023

AbstractThis article presents a new line tunneling dominating metal–semiconductor contact-induced SiGe–Si tunnel field-effect transistor with control gate (CG-Line SiGe/Si iTFET). With a structure where two symmetrical control gates at the drain region are given a sufficient negative bias, the overlap of the energy bands at the drain in the OFF-state is effectively suppressed, thus reducing the tunneling probability and significantly decreasing leakage current. Additionally, the large overlap area between the source and gate improves the gate’s ability to control the tunneling interface effectively, improving the ON-state current and subthreshold swing characteristics. By using the Schottky contact characteristics of a metal–semiconductor contact with different work functions to form a PN junction, the need to control doping profiles or random doping fluctuations is avoided. Furthermore, as ion implantation is not required, issues related to subsequent annealing are also eliminated, greatly reducing thermal budget. Due to the different material bandgap characteristics selected for the source and drain regions, the probability of overlap of the energy bands in the source region in the ON-state is increased and that in the drain region in the OFF-state is reduced. Based on the feasibility of the actual fabrication process and through rigorous 2D simulation studies, improvements in subthreshold swing and high on/off current ratio can be achieved simultaneously based on the proposed device structure. Additionally, the presence of the control gate structure effectively suppresses leakage current, further enhancing its potential for low-power-consumption applications.
Evaluating imputation methods for single-cell RNA-seq data
Authors: Cheng Yi , Ma Xiuli , Yuan Lang , Sun Zhaoguo , Wang Pingzhang 
Published: July 2023

Abstract
Background
Single-cell RNA sequencing (scRNA-seq) enables the high-throughput profiling of gene expression at the single-cell level. However, overwhelming dropouts within data may obscure meaningful biological signals. Various imputation methods have recently been developed to address this problem. Therefore, it is important to perform a systematic evaluation of different imputation algorithms.

Results
In this study, we evaluated 11 of the most recent imputation methods on 12 real biological datasets from immunological studies and 4 simulated datasets. The performance of these methods was compared, based on numerical recovery, cell clustering and marker gene analysis. Most of the methods brought some benefits on numerical recovery. To some extent, the performance of imputation methods varied among protocols. In the cell clustering analysis, no method performed consistently well across all datasets. Some methods performed poorly on real datasets but excellent on simulated datasets. Surprisingly and importantly, some methods had a negative effect on cell clustering. In marker gene analysis, some methods identified potentially novel cell subsets. However, not all of the marker genes were successfully imputed in gene expression, suggesting that imputation challenges remain.

Conclusions
In summary, different imputation methods showed different effects on different datasets, suggesting that imputation may have dataset specificity. Our study reveals the benefits and limitations of various imputation methods and provides a data-driven guidance for scRNA-seq data analysis.
Violence against women and associated factors among female construction workers in Addis Ababa, Ethiopia
Authors: Asegu Kidist Asratie , Dessie Anteneh Mengist , Tilahun Tizita Degifie , Dagnew Gizachew Worku , Anley Denekew Tenaw 
Published: July 2023

AbstractBackgroundViolence against Women (VAW) is a global public health problem; almost one in three global women experienced one form of violence. Violence free environment is the one that everyone cherishes. However, millions of women worldwide suffer from violence. In Ethiopia, VAW is very common and considered a private matter though it has serious consequences for girls and women. Studies pointed out that it varies by workplace, and hence important to assess it among female construction workers in Addis Ababa.ObjectiveTo assess the prevalence and factors contributing to gender-based violence on female construction workers in Addis Ababa, Ethiopia, 2021.MethodsA cross-sectional study design with a multistage cluster sampling technique was used to select 827 study participants and a face-to-face interview was held from February 24 to April 24, 2021. Data entry was done using Epi info-7 and exported to SPSS version 26 for analysis. Both bivariable and multivariable binary logistics regression analysis were employed.ResultsA total of 827 female workers were interviewed in this study. The mean age of the respondents was 24.97 years with SD of ± 5.6. The magnitude of violence against female in the workplace was 70.9% (95% CI: 67.7, 73.9). This study found that females in the age group 15–19 years (AOR = 2.37, 95%CI: 1.26, 4.45), females who live in Addis Ababa for less than 3 years (AOR = 3.02, 95%CI: 1.59, 5.73) and for 3–7 years (AOR = 2.14, 95% CI: 1.14, 4.00) and females who have no formal education (AOR = 3.16, 95%CI: 1.80, 5.54) had higher odds of violence at their workplace.ConclusionThe magnitude of overall VAW among female construction workers in Addis Ababa was high compared to other workplaces. Age and the number of years lived in Addis Ababa were found to be significant factors of violence among female construction workers. Hence, emphasis shall be given for female construction workers in Addis Ababa.
Job loss and psychological distress during the COVID-19 pandemic: a national prospective cohort study
Authors: Wörn Jonathan , Reme Bjørn-Atle , Skirbekk Vegard 
Published: July 2023

Abstract
Background
The COVID-19 pandemic caused substantial increases in unemployment; however, the association between these job losses and psychological distress is not well documented. Our study reports on this association from a cohort study, with a particular focus on educational differences in both the likelihood of job loss and its potential implications for mental health.

Methods
Utilizing data from a large prospective cohort study of parents in Norway (n = 58,982), we examined changes in psychological distress within four groups of respondents: those who during the first wave of COVID-19 had (i) no change in their employment situation, (ii) worked from home, (iii) been furloughed, or (iv) lost their job.

Results
Psychological distress increased in all groups. In z-scores relative to pre-pandemic levels, the increases were (i) 0.47 [95%-CI: 0.45–0.49] among respondents with no change in their employment situation, (ii) 0.51 [95%-CI: 0.49–0.53] among respondents who worked from home, (iii) 0.95 [95%-CI:0.91–0.99] among those furloughed, and (iv) 1.38 [95%-CI: 1.16–1.59] among those who permanently lost their job, corresponding to increases of 89%, 95%, 170%, and 185%, respectively. While respondents without university education had a 2 to 3 times higher risk of job loss, the negative impact of job loss on psychological distress was similar across educational levels.

Conclusions
Participants exposed to job loss during the pandemic experienced a stronger increase in symptoms of depression or anxiety compared to those who remained employed. Although higher education lowered the risk of losing work, it did not substantially diminish the impact on mental health from losing work.
Histological evaluation of the debris removal efficiency of activation of sodium hypochlorite solution at different concentrations
Authors: Özlek Esin , Acikgoz Eda , Gökkaya Nesibe Zeyneb , Taşan Ahmet , Altındağ Fikret 
Published: July 2023

Abstract
Background
This study aims to histologically evaluate the efficiency of debris removal through activation of 2.5% and 5.25% NaOCI using laser, ultrasonic, and intracanal heating methods.

Methods
Sixty-four maxillary central incisor teeth were randomly divided into two groups according to the irrigation solution (n = 32); 2.5% NaOCI and 5.25% NaOCI. Subsequently, the samples were further divided into four subgroups according to the final irrigation activation technique (n = 8); SubgroupA: Er,Cs:YSGG laser, SubgroupB: Ultrasonic, Subgroup C: Intracanal heating, Subgroup D: no activation. Generalized Linear Models and Bonferroni tests were used for statistical analysis (p < 0.05).

Results
The effect of NaOCI concentration was statistically significant (p < 0.001). Furthermore, the activation of NaOCI by laser exhibited a statistically significant difference compared to the ultrasonic and intracanal heating methods (p < 0.001).

Conclusion
The efficiency of root canal cleaning increases with higher NaOCI concentration. Activation of NaOCI also significantly enhances its effectiveness.
Public perceptions of advance care planning (ACP) from an international perspective: a scoping review
Authors: Canny Anne , Mason Bruce , Boyd Kirsty 
Published: July 2023

Abstract
Background
Advance Care Planning (ACP) helps people discuss personal values, goals and priorities regarding future care with family and professionals. It can support care coordination and guide decision-making as health deteriorates. However, uptake remains low internationally. Poor communication and information due to Covid-19 pressures exacerbated public and professional criticism and concerns. Recent recommendations highlight the importance of understanding and addressing public perceptions about ACP combined with person-centred approaches to ACP conversations.

Objectives
To explore public perceptions of ACP to inform increased public engagement and empowerment.

Methods
Joanna Briggs Institute methodology was applied in a rapid scoping review. Three databases (Embase, MEDLINE, APA PsycInfo) were searched for English language reviews and primary or secondary research studies from 2015 to 2021. Following title and abstract review, two researchers screened full-text articles and performed data extraction independently using Covidence. Charted data were analysed for themes and subthemes starting with two recent published reviews. Emerging findings were added and data synthesis reviewed by the research team, including public-patient representatives, to achieve consensus.

Results
Of 336 studies, 20 included reviews and research papers represented diverse public views, situations and contexts. Studies found poor public knowledge of ACP and widespread perceptions of confusing or accessible information. Multiple reports described little personal relevance, perceived risks of emotional distress, fears, mistrust and misconceptions about the purpose and scope of ACP. Studies identified public concerns stemming from reluctance to discuss death and dying despite this being just one aspect of ACP. Research with minority communities and marginalised groups found intensified concerns. Some studies cited people who valued maintaining autonomy by expressing their goals and preferences.

Conclusions
Studies reviewed found many members of the public had negative or unclear perceptions of ACP. Improved knowledge and understanding appeared to influence perceptions of ACP but were not considered sufficient to change behaviours. The research provided valuable insights from members of the public that could inform current professional and societal debates about the future of ACP. Findings point to a need for novel approaches to ACP public information and involvement whilst bearing in mind societal norms, diverse cultures and contexts.
Effects of online mindfulness-based interventions (MBIs) on anxiety symptoms in adults: a systematic review and meta-analysis
Authors: Reangsing Chuntana , Trakooltorwong Pimkanabhon , Maneekunwong Kunnara , Thepsaw Jintana , Oerther Sarah 
Published: July 2023

Abstract
Background
An increasing number of studies have documented the effectiveness on various types of face-to-face and online mindfulness-based interventions (MBIs) in reducing anxiety among general population, but there is a scarcity of systematic reviews evaluating evidence of online MBIs on anxiety in adults. Therefore, we examined the effects of online mindfulness-based interventions (MBIs) on anxiety symptoms in adults and explored the moderating effects of participant, methods, and intervention characteristics.

Methods
We systematically searched nine databases through May 2022 without date restrictions. Inclusion criteria were primary studies evaluating online mindfulness-based interventions with adults with anxiety measured as an outcome, a comparison group, and written in English. We used random-effects model to compute effect sizes (ESs) using Hedges’ g, a forest plot, and Q and I2 statistics as measures of heterogeneity; we also examined moderator analyses.

Results
Twenty-six primary studies included 3,246 participants (39.9 ± 12.9 years old). Overall, online mindfulness-based interventions showed significantly improved anxiety (g = 0.35, 95%CI 0.09, 0.62, I2 = 92%) compared to controls. With regards to moderators, researchers reported higher attrition, they reported less beneficial effects on anxiety symptoms (β=-0.001, Qmodel=4.59, p = .032). No other quality indicators moderated the effects of online mindfulness-based interventions on anxiety.

Conclusion
Online mindfulness-based interventions improved anxiety symptoms in adult population. Thus, it might be used as adjunctive or alternative complementary treatment for adults. However, our findings must be interpreted with caution due to the low and unclear power of the sample in primary studies; hence, high-quality studies are needed to confirm our findings.
Attitudes toward ophthalmology as a prospective career among pre-clinical medical students in China
Authors: Yu Yixin , Ding Yi , Paulus Yannis M. , Jiang Haibo 
Published: July 2023

AbstractBackgroundA questionnaire was developed and administered to 450 medical students at the Xiangya Medical College, Central South University in Changsha, China to understand the attitudes among medical students in China toward different medical specialties and to find the factors that influenced their choice of career in ophthalmology.ParticipantsFourth-year medical students in the five-year program and sixth-year medical students in the eight-year program.MethodsAll the students were asked to rate the importance of nine possible factors in choosing a specialty as their vocation and their first ranked future specialty career choice.ResultsWhen asked about the reasons for choosing to go to medical school, the top four reasons are the ability to help patients, interesting and challenging work, prestige, and job stability. When asked about the reasons for choosing a specialty, the top four reasons are the ability to find employment, financial reward, career upward mobility, and professional pressure. About the first career choice of the future specialty, for clinical medicine students, ophthalmology is the fifth ranked choice for clinical medicine students. 5.6% (five-year) and 3.4% (eight-year) of them choose ophthalmology as their top ranked specialty for their career. For anesthesia medicine and oral medicine students, most of them preferred to choose the same specialty as before. 1.5% (anesthesia) and 4.5% (oral) of them chose ophthalmology as their top ranked specialty.ConclusionsMedical students in China have numerous factors that motivate their choice in a specialty. Ophthalmology is the fifth ranked choice among clinical medicine students.
Contributions of the life expectancy gap reduction between urban and rural areas to the increase in overall life expectancy in South Korea from 2000 to 2019
Authors: Kim Ikhan 
Published: July 2023

Abstract
Background
This study aimed to quantify the contribution of narrowing the life expectancy gap between urban and rural areas to the overall life expectancy at birth in Korea and examine the age and death cause-specific contribution to changes in the life expectancy gap between urban and rural areas.

Methods
We used the registration population and death statistics from Statistics Korea from 2000 to 2019. Assuming two hypothetical scenarios, namely, the same age-specific mortality change rate in urban and rural areas and a 20% faster decline than the observed decline rate in rural areas, we compared the increase in life expectancy with the actual increase. Changes in the life expectancy gap between urban and rural areas were decomposed into age- and cause-specific contributions.

Results
Rural disadvantages of life expectancy were evident. However, life expectancies in rural areas increased more rapidly than in urban areas. Life expectancy would have increased 0.3–0.5 less if the decline rate of age-specific mortality in small-to-middle urban and rural areas were the same as that of large urban areas. Life expectancy would have increased 0.7–0.9 years further if the decline rate of age-specific mortality in small-to-middle urban and rural areas had been 20% higher. The age groups 15–39 and 40–64, and chronic diseases, such as neoplasms and diseases of the digestive system, and external causes significantly contributed to narrowing the life expectancy gap between urban and rural areas.

Conclusion
Pro-health equity interventions would be a good strategy to reduce the life expectancy gap and increase overall life expectancy, particularly in societies where life expectancies have already increased.