bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diving Deep into Fish Bornaviruses: Uncovering Hidden Diversity and Transcriptional Strategies through Comprehensive Data Mining
Authors: Eshak Mirette , Rubbenstroth Dennis , Beer Martin , Pfaff Florian 
Published: August 2023

ABSTRACTRecently, we discovered two novel orthobornaviruses in colubrid and viperid snakes using anin silicodata mining approach. Here, we present the results of a screening of more than 100,000 nucleic acid sequence datasets of fish samples from the Sequence Read Archive (SRA) for potential bornaviral sequences. We discovered the potentially complete genomes of seven bornaviruses in datasets from osteichthyans and chondrichthyans. Four of these are likely to represent novel species within the genusCultervirus, and we propose that one genome represents a novel genus within the family ofBornaviridae. Specifically, we identified sequences of Wǔhàn sharpbelly bornavirus (WhSBV) in sequence data from the widely used grass carp liver and kidney cell lines L8824 and CIK, respectively. A complete genome of Murray-Darling carp bornavirus (MDCBV) was identified in sequence data from a goldfish (Carassius auratus). The newly discovered little skate bornavirus (LSBV), identified in the little skate (Leucoraja erinacea) dataset, contained a novel and unusual genomic architecture (N-Vp1-Vp2-X-P-G-M-L), as compared to other bornaviruses. Its genome is thought to encode two additional open reading frames (tentatively named Vp1 and Vp2), which appear to represent ancient duplications of the gene encoding for the viral glycoprotein (G). The datasets also provided insights into the possible transcriptional gradients of these bornaviruses and revealed previously unknown splicing mechanisms.
A comparison of the parasitoid wasp species richness of tropical forest sites in Peru and Uganda – subfamily Rhyssinae (Hymenoptera: Ichneumonidae)
Authors: Tapani Hopkins , Hanna Tuomisto , Gómez Isrrael C. , Sääksjärvi Ilari E. 
Published: August 2023

ABSTRACTThe global distribution of parasitoid wasp species richness is poorly known. Past attempts to compare data from different sites have been hampered by small sample sizes and lack of standardisation. During the past decades, we have carried out long-term Malaise trapping using a standardised approach in the tropical forests of Peru (western Amazonia) and Uganda (eastern Africa). Here, we test how well such data can be used for global comparisons, by comparing the results for the subfamily Rhyssinae (Hymenoptera: Ichneumonidae). We found that more rhyssine species were caught in Peru than in Uganda, despite the Ugandan samples containing many more individuals both in absolute terms and per unit time. The difference in the number of individuals caught may largely be due to more rainfall in Peru, since rain reduces Malaise trap catches. Peruvian traps caught species at a faster rate (per individual caught) than Ugandan traps. We interpret this as a sign that the Peruvian sites have more species than the Ugandan site. Long-term, standardised Malaise trapping showed promise for global comparisons of species richness. Sampling more sites on both continents, and analysing all subfamilies, would give an estimate of which continent has more parasitoid wasp species. We suggest some refinements to the sampling design that would further improve sampling efficiency for future studies.
Off-targets of BRAF inhibitors disrupt endothelial signaling and differentially affect vascular barrier function
Authors: Bromberger Sophie , Zadorozhna Yuliia , Ressler Julia Maria , Holzner Silvio , Nawrocki Arkadiusz , Zila Nina , Springer Alexander , Larsen Martin Røssel , Schossleitner Klaudia 
Published: August 2023

AbstractTargeted therapies against mutant BRAF are effectively used in combination with MEK inhibitors (MEKi) to treat advanced melanoma. However, treatment success is affected by resistance and adverse events (AEs). Approved BRAF inhibitors (BRAFi) show high levels of target promiscuity, which can contribute to these effects. Blood vessels are in direct contact with high plasma concentrations of BRAFi, but effects of the inhibitors in this cell type are unknown. Hence, we aimed to characterize responses to approved BRAFi for melanoma in the vascular endothelium. We showed that all clinically approved BRAFi induced a paradoxical activation of endothelial MAPK signaling. Moreover, phosphoproteomics revealed distinct sets of off-targets per inhibitor. Endothelial barrier function and junction integrity were impaired upon treatment with Vemurafenib and the next-generation dimerization inhibitor PLX8394, but not with Dabrafenib or Encorafenib. Together, these findings provide insights on the surprisingly distinct side effects of BRAFi on endothelial signaling and functionality. Better understanding of off-target effects could help to identify molecular mechanisms behind AEs and guide the continued development of therapies for BRAF-mutant melanoma.
Structural equation modeling (SEM) analysis: an innovative female entrepreneurship education ecosystem in China
Authors: Feng Lei , Sumettikoon Piyapong 
Published: August 2023

PurposeThis study aims to add a gender perspective to the current ecosystem of entrepreneurship education whereby an innovative model of the female entrepreneurship education ecosystem (FEEE) consisting of five stakeholders (university, government, society, enterprise and the international community) is examined.Design/methodology/approachThe study conducted an online questionnaire among 505 respondents from two universities and one higher vocational college in China. Confirmatory factor analysis (CFA) was used to test the correlation between factors and structural equation modeling (SEM) was applied to test the five hypotheses proposed in the study.FindingsThe results indicated that the five stakeholders (the university, government, society, enterprise and international community) positively affect FEEE. The study emphasizes the urgent demand to consider gender perspectives in the ecosystem of entrepreneurship education and provides plausible ways to conduct female-targeted education with the joint efforts of different stakeholders.Practical implicationsThe study aims to increase the number of future female entrepreneurs, enhance the future skills of female students in the digital era and ultimately advance humankind. The study emphasizes the urgent demand to consider gender-perspective in the entrepreneurship education ecosystem and provides plausible ways to conduct female-targeted education with the joint efforts of different stakeholders.Originality/valueThis paper sheds light on evaluating FEEE through five stakeholders' dimensions, which explores the solutions to the current female entrepreneurship education (FEE) issues.
Views of African higher education scholars about effective leadership
Authors: Alemu Daniel S. 
Published: August 2023

PurposeThe purpose of this study is to investigate the views of African higher education scholars about effective leadership and if those views reflect a unique, African meaning of leadership.Design/methodology/approachThe study sought to explore the views of African higher education scholars about leadership in general and if those views reflect a unique, African meaning, that does not necessarily fit the widely accepted western theories. Using a researcher-designed questionnaire, higher education faculty and administrators were asked their understanding and beliefs about leadership. Data from quantitative responses were analyzed using descriptive statistics and t-test. In addition, qualitative answers, from one open ended question, were utilized to possibly triangulate with quantitative responses.FindingsThis study found that most research participants believe that the widely used western leadership theories are not fully applicable to Africa's context. However, the list of qualities of effective leadership, these participants suggest to be unique to Africa, included mixed attributes from Western, Non-Western and Culture-Neutral theories.Research limitations/implicationsThis study has some limitations. First, the data for this study was collected electronically which might have affected the potential responses from those with limited Internet connection or who have not updated their current email addresses. Second, the participants of the study are higher education professionals whose insight about leadership may not necessarily reflect the views of others from different background.Practical implicationsBy examining leadership effectiveness in Africa's context, this study adds to the body of literature on the ongoing discussion on the topic of culture and leadership. It is hoped that the findings of the study provide important insights regarding the debate on “western vs non-western” leadership theories.Originality/valueThe universal understanding of leadership and the application of leadership theories across cultures have been an issue of debate for leadership scholars and practitioners around the globe. Many authors argue that the widely used leadership theories are “too western” in value and character (Bass, 1990; Hofstede, 1993; House and Aditya, 1997). This study adds the perspectives of African scholars to the ongoing debate and expands the understanding about leadership across culture.
Does status demotion in hierarchical loyalty programs foster relationship fading?
Authors: Banik Shanta , Rabbanee Fazlul K. 
Published: August 2023

Purpose
Status demotion in hierarchical loyalty programs (HLPs) has received considerable academic attention. However, existing research is relatively silent on whether HLP status demotion fosters service relationship fading by influencing demoted customers’ psychological disengagement and the likelihood of patronage reduction. Drawing on the relationship fading literature and the stimulus–organism–response framework, this study aims to examine these effects. It further investigates the moderating role of psychological ownership on the links of status demotion with psychological disengagement and the likelihood of patronage reduction.

Design/methodology/approach
Two studies (Studies 1 and 2) were conducted in the context of airline HLPs. Study 1 was a structured survey conducted among 213 demoted airline HLP customers in Australia, and Study 2 was an experiment conducted among 178 executive MBA students in Bangladesh. The PROCESS macro was used to test the moderated mediation model.

Findings
The results of both studies show that HLP status demotion significantly influences customers’ psychological disengagement and the likelihood of patronage reduction. The findings also reveal that psychological disengagement mediates the relationship between status demotion and the likelihood of patronage reduction. Further, customers with high (low) psychological ownership feel high (less) psychological disengagement and show high (less) likelihood of patronage reduction due to their HLP status demotion.

Originality/value
This study extends the existing literature on relationship marketing and HLPs by offering a better understanding of how and under what conditions status demotion elicits customers’ psychological disengagement and the likelihood of patronage reduction.
The impact of COVID‐19 restrictions on the delivery of occupational therapy: How technology use affected practice during COVID‐19 among occupational therapists in British Columbia
Authors: Fawkes Tanya , Yung Olivia , Miller William C. , Smith Emma , Matharu Parmeet , Yu Natalie 
Published: August 2023

AbstractIntroductionCOVID‐19 activity restrictions altered clinical practice around the world. Anecdotal evidence observed by the Canadian Association of Occupational Therapists – British Columbia (CAOT‐BC) suggested a rapid adjustment to virtual care technologies occurred among occupational therapists in the initial restrictions. The purpose of the study was to determine the scope of how COVID‐19 restrictions impacted the use of technology to provide client care in British Columbia. It will inform the future provision of occupational therapy in the developing technological landscape related to heath care provision.MethodsThis descriptive cross‐sectional survey was completed using Qualtrics, an online survey tool. Registered occupational therapists received the survey via email invitations. The data were analysed using descriptive statistics in IBM SPSS Software.ResultsOf 342 participants, 98.4% reported increased technology use to support practice with the advent of COVID‐19 restrictions. Those with some technology experience prior to COVID‐19 reported higher intent to continue using technology following COVID‐19 restrictions. Overall, occupational therapists were confident in their perceived abilities to use technology in their practice. Occupational therapist‐related, client‐related, and practice area considerations occurred with the rapid uptake of technology. Some components of practice were perceived to be improved and others impaired with the use of technology.ConclusionOccupational therapists substantially increased their use of technology to enable ongoing client care during the Covid‐19 restrictions. Implications for improvements and reduction of limitations in care delivery are substantial, given the intent to continue using technology going forward. These implications can be further explored to understand how the advances in occupational therapists' ability to use technology may impact rural or remote care, which practice areas may be most amenable technology use, and how policies and funding can facilitate effective and appropriate use of technology to support clinical care in public and private settings.
Implementing evidence‐based clinical and business data standards in Australian private practice clinics is feasible
Authors: Clark Peter W. , Williams Lauren T. , O'Shea Marie‐Claire , Ball Lauren 
Published: August 2023

AbstractAimsTo assess the feasibility of implementing data standards in Australian primary care dietetics practices.MethodsA mixed‐methods pragmatic study of dietitians working in primary care. Using a four‐point Likert scale, participants were surveyed on their baseline use of the 45 business and 33 clinical evidenced‐based data standards. The content validity index and kappa statistic for each standard were calculated with a kappa statistic of 0.60–0.74 considered ‘Good’ and > 0.74 ‘Excellent’. After 4 weeks of assessment, dietitians were surveyed on the feasibility of implementing each standard and standards in total. Qualitative feedback on enablers and barriers to implementing standards was gathered and triangulated with interviews with select participants.ResultsForty‐five dietitians from every Australian state and territory completed both surveys (response rate: 100%). At baseline, 24% of business and 79% of clinical standards were rated ‘Good’ or ‘Excellent’ for current usage. The feasibility of implementing standards was rated ‘Good’ or ‘Excellent for 86% of the business and 97% of the clinical standards. Software, training and time limitations are enablers and barriers to implementing standards.ConclusionEmbedding data standards within dietetics practices are feasible and have broad applicability for assessing outcomes of care.
Study Design for Restricted Mean Time Analysis of Recurrent Events and Death
Authors: Mao Lu 
Published: August 2023

Abstract
The restricted mean time in favor (RMT-IF) of treatment has just been added to the analytic toolbox for composite endpoints of recurrent events and death. To help practitioners design new trials based on this method, we develop tools to calculate the sample size and power. Specifically, we formulate the outcomes as a multistate Markov process with a sequence of transient states for recurrent events and an absorbing state for death. The transition intensities, in this case the instantaneous risks of another nonfatal event or death, are assumed to be time-homogeneous but nonetheless allowed to depend on the number of past events. Using the properties of Coxian distributions, we derive the RMT-IF effect size under the alternative hypothesis as a function of the treatment-to-control intensity ratios along with the baseline intensities, the latter of which can be easily estimated from historical data. We also reduce the variance of the nonparametric RMT-IF estimator to calculable terms under a standard set-up for censoring. Simulation studies show that the resulting formulas provide accurate approximation to the sample size and power in realistic settings. For illustration, a past cardiovascular trial with recurrent-hospitalization and mortality outcomes is analyzed to generate the parameters needed to design a future trial. The procedures are incorporated into the rmt package along with the original methodology on the Comprehensive R Archive Network (CRAN).
Impact of GVHD on lymphoma progression: Nationwide study from Japanese Society for Transplantation and Cellular Therapy
Authors: Watanabe Mizuki , Kanda Junya , Fukuda Takahiro , Uchida Naoyuki , Ikegame Kazuhiro , Kataoka Keisuke , Kobayashi Hikaru , Ara Takahide , Ishikawa Jun , Matsuoka Ken‐ichi , Sugio Yasuhiro , Nakazawa Hideyuki , Ikeda Takashi , Atsuta Yoshiko , Kondo Eisei , Suzuki Ritsuro ,   Japanese Society for Transplantation and Cellular Therapy, Adult Lymphoma Working Group
Published: August 2023

SummaryThe graft‐versus‐lymphoma (GVL) effect and its association with acute and chronic GVHD (aGVHD, cGVHD) has not been comprehensively elucidated. We retrospectively analysed 2204 Japanese patients with non‐Hodgkin lymphomas (NHLs; indolent B‐NHLs, n = 689; aggressive B‐NHLs, n = 720; mature T/NK‐NHLs, n = 795) receiving a first allo‐HSCT in 2003–2017. Pre‐transplant lymphoma control showed complete response (CR) in 759 and non‐CR in 1445. We assessed the impact of aGVHD/cGVHD on lymphoma progression and other outcomes. Although aGVHD/cGVHD showed no statistical impact on lymphoma progression in the overall cohort, their impact was clear in certain groups: Grade I‐II aGVHD in CR patients (HR, 0.63; 95% CI, 0.43–0.91), especially in mature T/NK‐NHL (HR, 0.46; 95% CI, 0.26–0.83) and extensive cGVHD in patients with mature aggressive B‐NHLs (HR, 0.55; 95% CI, 0.31–0.97). In total, limited cGVHD was associated with superior survivals (progression‐free survival: HR, 0.71; 95% CI, 0.56–0.90), whereas severe GVHDs showed negative impacts on them. Our results support the presence of GVL effects differentially associated with GVHD in different lymphoma subtypes/controls. Meanwhile, it was also suggested that we should manage GVHDs within a limited activity, considering the negative impact of severe GVHDs. As pre‐transplant lymphoma control remains a strong factor influencing transplant outcomes, improving its management is an important issue to be addressed.
GingerenoneA overcomes dexamethasone resistance by activating apoptosis and inhibiting cell proliferation in pediatric T‐ALL cells
Authors: Katebi Melika , Rahgozar Soheila , Kazemi Farnoosh , Rahmani Saeideh , Najafi Dorcheh Somayeh 
Published: August 2023

AbstractPlant‐based combination strategies have been widely considered in cancer therapy to attenuate chemotherapeutics side effects. The anti‐leukemic effect of the whole ginger extract was previously portrayed by our team, and the current study is centered around the cytotoxicity and mechanism of action of a phenolic subsidiary of ginger, GingerenoneA, on pediatric acute lymphoblastic leukemia. GingernoneA imposed, dose‐dependently, inhibitory effects on the viability of T and B leukemia cell lines confirmed by MTT assays. Resistance to Dexamethasone, a mostly used chemotherapeutic in acute lymphoblastic leukemia treatments, was overcome by GingernoneA. A synergistic effect of Dexamethasone and GingrenoneA on T leukemia cell lines and patient primary cells was confirmed. Annexin‐V/PI and acridine orange/ethidium bromide staining illustrated dose‐dependent apoptosis in CCRF‐CEM cells developed by GingerenoneA. The intrinsic and extrinsic apoptosis induction and antiproliferative attribution of GingerenoneA were validated by western blot and qPCR. Despite the supposed loss of function in CCRF‐CEM cells, TP53 showed increased expression levels and functional activity upon treatment with GingernoneA. Bioinformatic studies revealed the conceivable impact of GingerenoneA on the reactivity of mutant P53 through its binding to Cys124. Our findings may provide novel strategies for therapeutic intervention to ameliorate pALL outcomes.
Visual and cognitive processes contribute to age‐related improvements in visual selective attention
Authors: Lynn Andrew , Maule John , Amso Dima 
Published: August 2023

AbstractChildren (N = 103, 4–9 years, 59 females, 84% White, c. 2019) completed visual processing, visual feature integration (color, luminance, motion), and visual search tasks. Contrast sensitivity and feature search improved with age similarly for luminance and color‐defined targets. Incidental feature integration improved more with age for color‐motion than luminance‐motion. Individual differences in feature search ( = .11) and incidental feature integration ( = .06) mediated age‐related changes in conjunction visual search, an index of visual selective attention. These findings suggest that visual selective attention is best conceptualized as a series of developmental trajectories, within an individual, that vary by an object's defining features. These data have implications for design of educational and interventional strategies intended to maximize attention for learning and memory.
An exploration of the domain specificity of maternal sensitivity among a diverse sample in the infancy period: Unique paths to child outcomes
Authors: Taraban Lindsay , Shaw Daniel S. , Morris Pamela A. , Mendelsohn Alan L. 
Published: August 2023

AbstractMaternal sensitivity during an observed mother–child clean‐up task at 18 months and maternal sensitivity during an observed mother–child free‐play task at 18 months were tested as independent predictors of child internalizing symptoms, externalizing symptoms, social competence, and language development at 24 months. Participants (n = 292 mothers) were recruited between 2015 and 2017, and were low‐income (mean annual income = $19,136) and racially and ethnically diverse (43.8% Black; 44.2% Latinx). Maternal sensitivity during clean‐up was a significant predictor of all social‐emotional outcomes, and a unique predictor of child internalizing symptoms. Maternal sensitivity during free‐play was a unique predictor of child language. Results suggest that context‐specific subtypes of maternal sensitivity may differentially relate to early child outcomes.
Use of tranexamic acid‐soaked NasoPore® in the emergency department, to reduce epistaxis admissions
Authors: Rosario Eleanor , Sharma Ekta , Patel Ankit , Guvensen Gabrielle , Ashroff Rizal , McClenaghan Fiona , Hariri Ahmad , Joseph Jonathan 
Published: August 2023

AbstractObjectivesThe aim of this study was to assess the efficacy of a new emergency department (ED) intervention for the management of non‐traumatic, anterior epistaxis in adult patients, aiming to reduce epistaxis admissions.DesignA new epistaxis pathway was introduced for use by ED practitioners. This was disseminated in ED through an educational campaign by the ear, nose and throat team. A tranexamic acid (500 mg/5 mL)‐soaked NasoPore® packing step was introduced for epistaxis which did not terminate following 10 min of simple first aid. The pathway was utilised for adult patients presenting with non‐traumatic, anterior epistaxis. Pre‐ and post‐implementation periods were defined, and all adults attending ED with non‐traumatic, anterior epistaxis were included. Pre‐ and post‐implementation epistaxis treatment interventions, admission rates and re‐attendance rates were recorded by retrospective audit and compared.ResultsIn the post‐implementation group, epistaxis admissions were 51.7% (p < .05) lower than in the pre‐implementation group, as a proportion of the total number attending ED with epistaxis during these periods.ConclusionsThe significant reduction in epistaxis admissions demonstrates that this ED intervention is beneficial for patient outcomes.