bluuebunny/crossref_metadata_2025_split huggingface dataset:
GRB 160410A: The first chemical study of the interstellar medium of a short GRB
Authors: Agüí Fernández J F , Thöne C C , Kann D A , de Ugarte Postigo A , Selsing J , Schady P , Yates R M , Greiner J , Oates S R , Malesani D B , Xu D , Klotz A , Campana S , Rossi A , Perley D A , Blažek M , D’Avanzo P , Giunta A , Hartmann D , Heintz K E , Jakobsson P , Kirkpatrick IV C C , Kouveliotou C , Melandri A , Pugliese G , Salvaterra R , Starling R L C , Tanvir N R , Vergani S D , Wiersema K 
Published: January 2023

ABSTRACT
Short gamma-ray bursts (SGRBs) are produced by the coalescence of compact binary systems which are remnants of massive stars. GRB 160410A is classified as a short-duration GRB with extended emission and is currently the farthest SGRB with a redshift determined from an afterglow spectrum and also one of the brightest SGRBs to date. The fast reaction to the Neil Gehrels Swift Observatory alert allowed us to obtain a spectrum of the afterglow using the X-shooter spectrograph at the Very Large Telescope (VLT). The spectrum shows several absorption features at a redshift of z = 1.7177, in addition, we detect two intervening systems at z = 1.581 and z = 1.444. The spectrum shows Ly α in absorption with a column density of log (N(H i)/cm2) = 21.2 ± 0.2 which, together with Fe ii, C ii, Si ii, Al ii, and O i, allow us to perform the first study of chemical abundances in a SGRB host galaxy. We determine a metallicity of [X/H] = −2.3 ± 0.2 for Fe ii and −2.5 ± 0.2 for Si ii and no dust depletion. We also find no evidence for extinction in the afterglow spectral energy distribution modelling. The environment has a low degree of ionization and the C iv and Si iv lines are completely absent. We do not detect an underlying host galaxy down to deep limits. Additionally, we compare GRB 160410A to GRB 201221D, another high-z short GRB that shows absorption lines at z = 1.045 and an underlying massive host galaxy.
Interface instabilities in hydrodynamic relativistic jets
Authors: Abolmasov Pavel , Bromberg Omer 
Published: January 2023

ABSTRACT
Both the dynamics and the observational properties of relativistic jets are determined by their interaction with the ambient medium. A crucial role is played by the contact discontinuity at the jet boundary, which in the presence of jet collimation may become subject to Rayleigh–Taylor instability (RTI) and Richtmyer–Meshkov instability (RMI). Here, we study the evolution of these instabilities in non-magnetized relativistic jets using special relativistic three-dimensional hydrodynamic simulations. We show that the growth of initial perturbations is consistent with relativistic RTI operating in the jet collimation region. The contribution of RMI becomes important downstream from the collimation shock in agreement with the theoretical expectations. Both instabilities reach non-linear scales above the shock convergence point and trigger strong turbulence, mixing the jet with the ambient matter. We devise an analytic solution for the mixing rate and show that it is sensitive to the external density gradients. Our results may be applied to different types of astrophysical objects. In particular, different contribution of interface instabilities is a natural explanation for the observed dichotomy between FR-I and FR-II radiogalaxies. The rapid slow-down in the jet of M87 is consistent with baryon entrainment from the circumnuclear matter with the observed density distribution. In microquasars, baryon loading triggered by interface instabilities is a probable reason for the low observed Lorentz factors. We show that the observed variability in gamma-ray bursts cannot come from mixing driven by interface instabilities and likely originates from the engine, suggesting the presence of magnetic fields in the jet.
OzDES Reverberation Mapping Program: Hβ lags from the 6-yr survey
Authors: Malik U , Sharp R , Penton A , Yu Z , Martini P , Lidman C , Tucker B E , Davis T M , Lewis G F , Aguena M , Allam S , Alves O , Andrade-Oliveira F , Asorey J , Bacon D , Bertin E , Bocquet S , Brooks D , Burke D L , Carnero Rosell A , Carollo D , Carrasco Kind M , Carretero J , Costanzi M , da Costa L N , Pereira M E S , De Vicente J , Desai S , Diehl H T , Doel P , Everett S , Ferrero I , Frieman J , García-Bellido J , Gerdes D W , Gruen D , Gruendl R A , Gschwend J , Hinton S R , Hollowood D L , Honscheid K , James D J , Kuehn K , Marshall J L , Mena-Fernández J , Menanteau F , Miquel R , Ogando R L C , Palmese A , Paz-Chinchón F , Pieres A , Plazas Malagón A A , Raveri M , Rodriguez-Monroy M , Romer A K , Sanchez E , Scarpine V , Sevilla-Noarbe I , Smith M , Soares-Santos M , Suchyta E , Swanson M E C , Tarle G , Taylor G , Tucker D L , Weaverdyck N , Wilkinson R D 
Published: January 2023

ABSTRACT
Reverberation mapping measurements have been used to constrain the relationship between the size of the broad-line region and luminosity of active galactic nuclei (AGN). This R–L relation is used to estimate single-epoch virial black hole masses, and has been proposed to use to standardize AGN to determine cosmological distances. We present reverberation measurements made with Hβ from the 6-yr Australian Dark Energy Survey (OzDES) Reverberation Mapping Program. We successfully recover reverberation lags for eight AGN at 0.12 &lt; z &lt; 0.71, probing higher redshifts than the bulk of Hβ measurements made to date. Our fit to the R–L relation has a slope of α = 0.41 ± 0.03 and an intrinsic scatter of σ = 0.23 ± 0.02 dex. The results from our multi-object spectroscopic survey are consistent with previous measurements made by dedicated source-by-source campaigns, and with the observed dependence on accretion rate. Future surveys, including LSST, TiDES, and SDSS-V, which will be revisiting some of our observed fields, will be able to build on the results of our first-generation multi-object reverberation mapping survey.
Stellar feedback-regulated black hole growth: driving factors from nuclear to halo scales
Authors: Byrne Lindsey , Faucher-Giguère Claude-André , Stern Jonathan , Anglés-Alcázar Daniel , Wellons Sarah , Gurvich Alexander B , Hopkins Philip F 
Published: January 2023

ABSTRACT
Several recent simulations of galaxy formation predict two main phases of supermassive black hole (BH) accretion: an early, highly intermittent phase (during which BHs are undermassive relative to local scaling relations), followed by a phase of accelerated growth. We investigate physical factors that drive the transition in BH accretion in cosmological zoom-in simulations from the FIRE project, ranging from dwarf galaxies to galaxies sufficiently massive to host luminous quasars. The simulations model multichannel stellar feedback, but neglect AGN feedback. We show that multiple physical properties, including halo mass, galaxy stellar mass, and depth of the central gravitational potential correlate with accelerated BH fuelling: constant thresholds in these properties are typically crossed within ∼0.1 Hubble time of accelerated BH fuelling. Black hole masses increase sharply when the stellar surface density in the inner 1 kpc crosses a threshold $\Sigma^\star _{1\,\rm kpc}\approx 10^{9.5} \, {\rm M_{\odot }}\,{\rm kpc}^{-2}$, a characteristic value above which gravity prevents stellar feedback from ejecting gas, and similar to the value above which galaxies are observed to quench. We further show that accelerated BH growth correlates with the emergence of long-lived thin gas discs, as well as with virialization of the inner circumgalactic medium. The halo mass Mhalo ∼ 1012 M⊙ and stellar mass M* ∼ 1010.5 M⊙ at which BH growth accelerates correspond to ∼L⋆ galaxies. The fact that stellar feedback becomes inefficient at ejecting gas from the nucleus above this mass scale may play an important role in explaining why AGN feedback appears to be most important in galaxies above L⋆.
The core normal Type Ia supernova 2019np – an overall spherical explosion with an aspherical surface layer and an aspherical 56Ni core
Authors: Hoeflich Peter , Yang Yi , Baade Dietrich , Cikota Aleksandar , Maund Justyn R , Mishra Divya , Patat Ferdinando , Patra Kishore C , Wang Lifan , Wheeler J Craig , Filippenko Alexei V , Gal-Yam Avishay , Schulze Steven 
Published: January 2023

ABSTRACT
Optical spectropolarimetry of the normal thermonuclear supernova (SN) 2019np from −14.5 to +14.5 d relative to B-band maximum detected an intrinsic continuum polarization (pcont) of 0.21 ± 0.09 per cent at the first epoch. Between days −11.5 and +0.5, pcont remained ∼0 and by day +14.5 was again significant at 0.19 ± 0.10 per cent. Not considering the first epoch, the dominant axis of ${\rm Si\, {\small II}}$ λ6355 was roughly constant staying close the continuum until both rotated in opposite directions on day +14.5. Detailed radiation-hydrodynamical simulations produce a very steep density slope in the outermost ejecta so that the low first-epoch pcont ≈ 0.2 per cent nevertheless suggests a separate structure with an axis ratio ∼2 in the outer carbon-rich (3.5–4) × 10−3 M⊙. Large-amplitude fluctuations in the polarization profiles and a flocculent appearance of the polar diagram for the ${\rm Ca\, {\small II}}$ near-infrared triplet (NIR3) may be related by a common origin. The temporal evolution of the polarization spectra agrees with an off-centre delayed detonation. The late-time increase in polarization and the possible change in position angle are also consistent with an aspherical 56Ni core. The pcont and the absorptions due to ${\rm Si\, {\small II}}$ λ6355 and ${\rm Ca\, {\small II}}$ NIR3 form in the same region of the extended photosphere, with an interplay between line occultation and thermalization producing p. Small-scale polarization features may be due to small-scale structures, but many could be related to atomic patterns of the quasi-continuum; they hardly have an equivalent in the total-flux spectra. We compare SN 2019np to other SNe and develop future objectives and strategies for SN Ia spectropolarimetry.
Re-evaluating Homoploid Reticulate Evolution in Helianthus Sunflowers
Authors: Owens Gregory L , Huang Kaichi , Todesco Marco , Rieseberg Loren H 
Published: January 2023

Abstract
Sunflowers of the genus Helianthus are models for hybridization research and contain three of the best-studied examples of homoploid hybrid speciation. To understand a broader picture of hybridization within the annual sunflowers, we used whole-genome resequencing to conduct a phylogenomic analysis and test for gene flow between lineages. We find that all annual sunflower species tested have evidence of admixture, suggesting hybridization was common during the radiation of the genus. Support for the major species tree decreases with increasing recombination rate, consistent with hybridization and introgression contributing to discordant topologies. Admixture graphs found hybridization to be associated with the origins of the three putative hybrid species (Helianthus anomalus, Helianthus deserticola, and Helianthus paradoxus). However, the hybridization events are more ancient than suggested by previous work. Furthermore, H. anomalus and H. deserticola appear to have arisen from a single hybridization event involving an unexpected donor, rather than through multiple independent events as previously proposed. This means our results are consistent with, but not definitive proof of, two ancient independent homoploid hybrid speciation events in the genus. Using a broader data set that covers the whole Helianthus genus, including perennial species, we find that signals of introgression span the genus and beyond, suggesting highly divergent introgression and/or the sorting of ancient haplotypes. Thus, Helianthus can be viewed as a syngameon in which largely reproductively isolated species are linked together by occasional or frequent gene flow.
Periprosthetic humeral fracture revision using a massive allograft in a patient with rheumatoid arthritis: A case report
Authors: Kishimoto Kenji , Kojima Toshihisa , Takahashi Nobunori , Asai Shuji , Terabe Kenya , Suzuki Mochihito , Ohashi Yoshifumi , Kihira Daisuke , Maeda Masataka , Tatebe Masahiro , Imagama Shiro 
Published: January 2023

ABSTRACT
Total elbow arthroplasty (TEA) is a surgical option for patients with rheumatoid arthritis (RA). Periprosthetic fractures during and after TEA are one of the most common causes of reoperation. Fractures around the stem of a loose prosthesis with associated bone loss are the most technically challenging to treat. Previous reports have demonstrated that the use of massive allografts is a reasonable alternative in salvage situations. Here, we report the case of a 78-year-old woman with RA who underwent revision TEA using massive allografts with modifications to the methods described in previous reports. She suffered a right periprosthetic humeral fracture 5 years after primary TEA, with a fracture in the proximal humeral diaphysis and a long spiral fracture in the diaphysis. The fracture around the stem of a loose prosthesis was associated with bone loss. We performed revision TEA using an allograft of the proximal femoral diaphysis. In contrast to previous reports, we preserved part of the humeral diaphysis, which was thin due to osteolysis, without removal. The advantage of this approach was that it preserved attachments, such as the deltoid and brachioradialis muscles. The patient had good elbow function and minimal pain without adverse events at 1 year postoperatively. Our findings suggest that preserving part of a thinned humeral diaphysis is a reasonable option in revision TEA with a massive composite allograft.
Association between animal protein sources and risk of neurodegenerative diseases: a systematic review and dose-response meta-analysis
Authors: Talebi Sepide , Asoudeh Farzaneh , Naeini Fatemeh , Sadeghi Erfan , Travica Nikolaj , Mohammadi Hamed 
Published: January 2023

Abstract

Context
Current findings about the differential effects of various sources of dietary animal protein on the risk of neurodegenerative diseases are contradictory.

Objective
The current meta-analysis was conducted to investigate the associations between intake of dietary animal protein sources and the risk of neurodegenerative diseases.

Data Sources
PubMed, Scopus, Web of Science, and Google Scholar databases were searched systematically until October 2021.

Data Extraction
Prospective cohort studies exploring the association between consumption of animal protein sources and risk of neurodegenerative diseases in the general population were included. Among 10 571 identified studies, 33 prospective cohort studies met the eligibility criteria.

Data Analysis
Dietary fish consumption was associated with a reduced risk of Alzheimer’s disease (RR = 0.75; 95%CI, 0.57–0.97), dementia (RR = 0.84; 95%CI, 0.75–0.93), and cognitive impairment (RR = 0.85; 95%CI, 0.81–0.95). The risk of developing Parkinson’s disease was significantly higher among those in the highest vs the lowest intake categories of total dairy (RR = 1.49; 95%CI, 1.06–2.10) and milk (RR = 1.40; 95%CI, 1.13–1.73). Moreover, dietary intake of total dairy (RR = 0.89; 95%CI, 0.80–0.99), total meat (RR = 0.72; 95%CI, 0.57–0.90), and poultry (RR = 0.82; 95%CI, 0.68–0.99) was significantly associated with a lower risk of cognitive impairment. A linear dose-response meta-analysis revealed that each 200-g increase in total daily dairy intake was associated with an 11% higher risk of Parkinson’s disease and a 12% lower risk of cognitive impairment. Furthermore, there was a strong linear association between fish consumption and reduced risk of dementia.

Conclusion
Dairy consumption is associated with an increased risk of Parkinson’s disease, but a higher intake of fish may be associated with lower risk of neurodegenerative disease. Future well-controlled, randomized clinical trials are essential to validate the present findings.

Systematic Review Registration
PROSPERO registration no. CRD42021281887.
Combining Sunitinib and Bevacizumab for the Management of Advanced Renal Cell Carcinoma: A Phase I/II Trial
Authors: Bazarbashi Shouki , Alzahrani Ahmed , Aljubran Ali , Elshenawy Mahmoud , Gad Ahmed Mostafa , Maraiki Fatima , Alzannan Noura , Elhassan Tusneem , Badran Ahmed 
Published: January 2023

Abstract

Background
Tyrosine kinase inhibitors remain a cornerstone in managing metastatic clear cell renal cell carcinoma (RCC). The 4 weeks on/2 weeks off intermittent sunitinib schedule could result in rebound angiogenesis and tumor progression in the 2-week rest period. We propose using bevacizumab during this period for continuous antiangiogenic effects.

Method
This was a phase I/II study of patients with advanced clear cell RCC. Sunitinib was given 50 mg daily on a 4-week on/2-week off schedule. Bevacizumab was given on day 29 of each sunitinib cycle. The bevacizumab starting dose was 5 mg/kg, and the dose was escalated to 10 mg if there was no dose-limiting toxicity. The primary endpoints were response rate and progression-free survival (PFS).

Results
Twenty-five patients were recruited. The study was closed prematurely because of poor accrual. No dose-limiting toxicity was observed with 5 mg bevacizumab. One patient achieved a complete response, and 12 achieved a partial response (52% response rate). At a median follow-up of 42.2 months (95%, confidence interval (CI) 32.9 to 51.4), the median PFS duration was 16.5 months (95% CI 4.1-28.8), and the median overall survival time was 33.3 months (95% CI 19.4-47.3). Twenty-two patients (88%) had at least one grade 3 or 4 toxicity; the most common were thrombocytopenia (32%), lymphopenia (32%), hypertension (28%), and fatigue (24%).

Conclusion
Continuous angiogenesis blockade by adding bevacizumab to the sunitinib on/off regimen for advanced RCC yields significant antitumor activity with manageable increased toxicity.
‘Managing Business with Respect’
Authors: Pachpande Sandeep , Pachpande Asha , Kulkarni J A 
Published: January 2023

Abstract
The ITC India company was incorporated in 1910. Much has changed in these 100 years. ITC itself has metamorphosed in many ways, the least of which is the multiple changes in nomenclature. What began and stayed for long as only a cigarette maker has turned into a conglomerate offering a dashboard of products and services, ranging from hospitality to toiletry to apparel to food. Of course, cigarettes remain a big but gradually shrinking part of its overall business.
Strategies for enriching and characterizing proteins with inhibitory properties on the yeast surface
Authors: Rezhdo Arlinda , Lessard Catherine T , Islam Mariha , Van Deventer James A 
Published: January 2023

Abstract
Display technologies are powerful tools for discovering binding proteins against a broad range of biological targets. However, it remains challenging to adapt display technologies for the discovery of proteins that inhibit the enzymatic activities of targets. Here, we investigate approaches for discovering and characterizing inhibitory antibodies in yeast display format using a well-defined series of constructs and the target matrix metalloproteinase-9. Three previously reported antibodies were used to create model libraries consisting of inhibitory, non-inhibitory, and non-binding constructs. Conditions that preferentially enrich for inhibitory clones were identified for both magnetic bead-based enrichments and fluorescence-activated cell sorting. Half maximal inhibitory concentration (IC50) was obtained through yeast titration assays. The IC50 of the inhibitory antibody obtained in yeast display format falls within the confidence interval of the IC50 value determined in soluble form. Overall, this study identifies strategies for the discovery and characterization of inhibitory clones directly in yeast display format.
Use of the psychomotor vigilance test to aid in the selection of risk controls in an air medical transport operation
Authors: Mollicone Daniel J , Kan Kevin , Coats Sara , Mott Christopher , van Wollen Matthew , Hatch Arvida , Gallagher Joseph , Williams Sheryl , Motzkin David 
Published: January 2023

AbstractStudy ObjectivesThis study evaluated the utility and ecological validity of the 3-minute psychomotor vigilance test (PVT) completed by safety-critical personnel in an air medical transport operation as part of a fatigue risk management program.MethodsCrewmembers in an air medical transport operation self-administered an alertness assessment incorporating a 3-minute PVT at different time points during their duty schedule. The prevalence of alertness deficits was evaluated based on a failure threshold of 12 errors considering both lapses and false starts. To evaluate the ecological validity of the PVT, the relative frequency of failed assessments was evaluated relative to crewmember position, timing of the assessment within the duty schedule, time of day, and sleep quantity in the last 24 h.Results2.1% of assessments were associated with a failing PVT score. Crewmember position, timing of assessment within the duty shift, time of day, and sleep quantity in the last 24 h were found to affect the relative frequency of failed assessments. Obtaining less than 7–9 h of sleep was associated with systematic increases in the failure rate (F[1, 54 612] = 168.1, p &lt; .001). Obtaining less than 4 h of sleep was associated with a frequency of a failed assessment 2.99 times higher than the frequency of a failed assessment when obtaining 7–9 h of sleep.ConclusionsResults provide evidence for the utility and ecological validity of the PVT as well as the suitability of the PVT failure threshold to support fatigue risk management in safety-critical operations.
Mancozeb-induced hepatotoxicity: protective role of curcumin in rat animal model
Authors: Aprioku Jonah Sydney , Amamina Ayanabia Monica , Nnabuenyi Perpetua Amarachi 
Published: January 2023

AbstractBackgroundMancozeb—a widely used fungicide in the agricultural sector—is believed to cause toxicity by increasing oxidative stress. This work investigated the efficacy of curcumin in protecting mancozeb-induced hepatotoxicity.Materials and MethodsMature Wistar rats were assigned into 4 equal groups: control, mancozeb (30 mg/kg/day, ip), curcumin (100 mg/kg/day, po), and mancozeb+curcumin. The experiment lasted for 10 days.ResultsOur results reported that mancozeb elevated aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, gamma glutamyltranspeptidase enzyme activities, and total bilirubin level in plasma; and decreased total protein and albumin levels, compared with the control group (P &lt; 0.05–0.001). Hepatic tissue levels of malondialdehyde, and advanced oxidation protein products were significantly increased; whereas activities of superoxide dismutase, catalase, glutathione peroxidase, as well as levels of reduced glutathione, vitamin C, and total protein were reduced (P &lt; 0.05–0.001). Histopathological examination showed marked histological changes. Co-treatment with curcumin improved the antioxidant activity; reversed oxidative stress and biochemical changes; and restored most of the liver histo-morphological alterations; thus, attenuating the hepatic toxicities induced by mancozeb.ConclusionThese results indicated that curcumin could protect against detrimental hepatic effects induced by mancozeb.