bluuebunny/crossref_metadata_2025_split huggingface dataset:
MARCH5-dependent NLRP3 ubiquitination is an essential step for NEK7 docking on the mitochondria
Authors: Park Yeon-Ji , Dodantenna Niranjan , Kim Tae-Hwan , Lee Ho-Soo , Yoo Young-Suk , Lee Eun-Seo , Lee Jae-Ho , Kwon Myung-Hee , Kang Ho Chul , Lee Jong-Soo , Cho Hyeseong 
Published: January 2023

AbstractThe NLRP3 inflammasome is a global immune-sensor that is activated by a repertoire of endogenous and exogenous stimuli. NLRP3 translocates to mitochondria but whether mitochondria involvement in the inflammasome assembly is unclear. Here, we show that the mitochondrial E3 ligase MARCH5 is a key regulator of NLRP3 inflammasome assembly. Myeloid cell-specificMarch5 conditional knockout (March5cKO) mice exhibited an attenuated mortality rate upon LPS orPseudomonas aeruginosachallenge. Macrophages derived fromMarch5cKO mice failed to secrete IL-1β and IL-18 after microbial infection. Mechanistically, MARCH5 interacts with the NACHT domain of NLRP3 and promotes K27-linked polyubiquitination of K324 and K430 residues of NLRP3. Ubiquitination-defective NLRP3 mutants neither bind to NEK7, nor form NLRP3 oligomers, but remain binding to MAVS. Accordingly, NLRP3 mutants led to abortive ASC speck formation and diminished IL-1β production. We propose that MARCH5-dependent NLRP3 ubiquitination creates a docking site for NEK7 binding, playing as a fundamental step-wise regulator on the mitochondria.
Corporate social responsibility decoupling: a systematic literature review and future research agenda
Authors: Talpur Shabana , Nadeem Muhammad , Roberts Helen 
Published: January 2023

PurposeThis paper aims to synthesize the corporate social responsibility decoupling (CSRD) literature, CSRD's causes and consequences and discuss other organizational attributes examined by CSRD scholars during 2010 and 2020. The authors provide suggestions for a future research agenda in this domain.Design/methodology/approachThe authors' systematic literature review (SLR) uses the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework to extract CSRD studies. The authors filter collected articles against quality and relevancy criteria and finally review 175 published articles.FindingsA theme analysis identifies and structures the many themes related to CSRD. The authors discuss the drivers of CSRD and reveal the consequences companies face after CSRD. The authors also provide a comprehensive CSRD discussion in the context of developed and developing economies. CSR communication is also identified as a tool for decoupling and recoupling.Research limitations/implicationsThe identified themes provide a thorough illustration of CSRD literature for new CSRD scholars. The authors also provide suggestions for future research, such as examining country-level policy-making and implications of CSRD variance and identifying cultural and economic hurdles to achieving core CSR purposes.Practical implicationsPolicymakers and scholars may adopt the approach that CSRD is a misreporting of information similar to accounting fraud. This is particularly relevant given that an increasing number of CSRD scandals indicate that the purpose of bringing change through corporate CSR has not been adopted well by corporations.Originality/valueThe authors' study offers a comprehensive literature review for the period of 2010–2020. The studies identified are structured into meaningful themes which can provide groundwork for future researchers.
Homelessness: partnerships and approaches to tackling complex needs
Authors: Woods Angela , Hughes Ben , Lace Rebecca , Dickinson Joanne 
Published: January 2023

Purpose
This paper – the first of three – aims to explore some of the complex physical and mental health needs of those experiencing homelessness. It will act as a leader to the other articles by establishing the nature of the problem and offer a rationale for carrying out a service user needs assessment as part of a review of local service provision in the North West of England against the backdrop of the current COVID-19 epidemic.

Design/methodology/approach
There are a number of complex social and health inequalities often experienced by those who are homeless. Effectively tackling these requires a co-ordinated multi-agency response to both prevent and tackle the harms associated with being and becoming homeless.

Findings
Partnership working offers the best opportunity to meet the complex needs of those experiencing homelessness. The current delivery model being actioned in the North West of England highlights the importance of the links between statutory and non-statutory services. An ongoing service user needs assessment will further help to highlight contemporary issues faced by those experiencing homelessness and those providing services in the context of the COVID-19 epidemic.

Social implications
Future papers as part of this series of three will consider the implications of social exclusion and barriers to accessing services faced on a day-to-day basis by those experiencing homelessness.

Originality/value
The opportunity to reflect on established views in relation to the nature and scope of homelessness. It will consider the implications exclusion from society and service provision that this group face on a day-to-day basis. The paper will describe a contemporary approach to tackling current issues faced by those experiencing homelessness in the current context of the COVID-19 epidemic.
The subtle art of (re)framing your mind
Authors: Yousef Dima 
Published: January 2023

PurposeThe purpose of this study is to explore through the author’s personal experience the impact rebuilding the author’s well-being had on the author’s identity and efficacy as a teacher. This describes the author’s experiences after the death of the author’s father and the effect of the author’s emotional state on the author’s personal and professional identity. It also explores how the author developed sustainable habits to cope with daily challenges.Design/methodology/approachThe study adopts an auto-ethnographic approach utilizing journal entries and reflections collected over the years as part of the healing process. These will provide a descriptive view of the author’s emotional state in the years after the author’s father's death. The author employed this method to explore the author’s personal experiences and provide a better understanding of the connections between the reconstruction of the professional identity and the importance of well-being and mental health in light of a significant or transformative event.FindingsThe paper provides insights about the significance of a positive mind-set on the efficacy and performance of teachers. This suggests that there is a connection between the impact of improving the author’s well-being on a personal and professional level.Originality/valueThere is little research on how self-efficacy or coping strategies could have an impact on teachers. The paper offers a unique insight into teachers' emotional and academic identities.
Raising offspring increases ageing: Differences in senescence among three populations of a long‐lived seabird, the Atlantic puffin
Authors: Landsem Terje L. , Yoccoz Nigel G. , Layton‐Matthews Kate , Hilde Christoffer H. , Harris Michael P. , Wanless Sarah , Daunt Francis , Reiertsen Tone K. , Erikstad Kjell E. , Anker‐Nilssen Tycho 
Published: January 2023

AbstractActuarial senescence, the decline of survival with age, is well documented in the wild. Rates of senescence vary widely between taxa, to some extent also between sexes, with the fastest life histories showing the highest rates of senescence. Few studies have investigated differences in senescence among populations of the same species, although such variation is expected from population‐level differences in environmental conditions, leading to differences in vital rates and thus life histories.We predict that, within species, populations differing in productivity (suggesting different paces of life) should experience different rates of senescence, but with little or no sexual difference in senescence within populations of monogamous, monomorphic species where the sexes share breeding duties.We compared rates of actuarial senescence among three contrasting populations of the Atlantic puffinFratercula arctica. The dataset comprised 31 years (1990–2020) of parallel capture–mark–recapture data from three breeding colonies, Isle of May (North Sea), Røst (Norwegian Sea) and Hornøya (Barents Sea), showing contrasting productivities (i.e. annual breeding success) and population trends. We used time elapsed since first capture as a proxy for bird age, and productivity and the winter North Atlantic Oscillation Index (wNAO) as proxies for the environmental conditions experienced by the populations within and outside the breeding season, respectively.In accordance with our predictions, we found that senescence rates differed among the study populations, with no evidence for sexual differences. There was no evidence for an effect of wNAO, but the population with the lowest productivity, Røst, showed the lowest rate of senescence. As a consequence, the negative effect of senescence on the population growth rate (λ) was up to 3–5 times smaller on Røst (Δλ = −0.009) than on the two other colonies.Our findings suggest that environmentally induced differences in senescence rates among populations of a species should be accounted for when predicting effects of climate variation and change on species persistence. There is thus a need for more detailed information on how both actuarial and reproductive senescence influence vital rates of populations of the same species, calling for large‐scale comparative studies.
SATB2, coordinated with CUX1, regulates IL‐1β‐induced senescence‐like phenotype in endothelial cells by fine‐tuning the atherosclerosis‐associated p16INK4a expression
Authors: Wu Ting , Wu Yuwei , Jiang Danli , Sun Wei , Zou Meijuan , Vasamsetti Sathish Babu , Dutta Partha , Leers Steven A. , Di Wu , Li Gang 
Published: January 2023

AbstractGenome‐wide association studies (GWAS) have validated a strong association of atherosclerosis with the CDKN2A/B locus, a locus harboring three tumor suppressor genes: p14ARF, p15INK4b, and p16INK4a. Post‐GWAS functional analysis reveals that CUX is a transcriptional activator of p16INK4a via its specific binding to a functional SNP (fSNP) rs1537371 on the atherosclerosis‐associated CDKN2A/B locus, regulating endothelial senescence. In this work, we characterize SATB2, another transcription factor that specifically binds to rs1537371. We demonstrate that even though both CUX1 and SATB2 are the homeodomain transcription factors, unlike CUX1, SATB2 is a transcriptional suppressor of p16INK4a and overexpression of SATB2 competes with CUX1 for its binding to rs1537371, which inhibits p16INK4a and p16INK4a‐dependent cellular senescence in human endothelial cells (ECs). Surprisingly, we discovered that SATB2 expression is transcriptionally repressed by CUX1. Therefore, upregulation of CUX1 inhibits SATB2 expression, which enhances the binding of CUX1 to rs1537371 and subsequently fine‐tunes p16INK4a expression. Remarkably, we also demonstrate that IL‐1β, a senescence‐associated secretory phenotype (SASP) gene itself and a biomarker for atherosclerosis, induces cellular senescence also by upregulating CUX1 and/or downregulating SATB2 in human ECs. A model is proposed to reconcile our findings showing how both primary and secondary senescence are activated via the atherosclerosis‐associated p16INK4a expression.
End‐of‐life care in the intensive care unit
Authors: Tanaka Gutiez M. , Efstathiou N. , Innes R. , Metaxa V. 
Published: January 2023

SummaryThe transition from active, invasive interventions to comfort care for critical care patients is often fraught with misunderstandings, conflict and moral distress. The most common issues that arise are ethical dilemmas around the equivalence of withholding and withdrawing life‐sustaining treatment; the doctrine of double effect; the balance between paternalism and shared decision‐making; legal challenges around best‐interest decisions for patients that lack capacity; conflict resolution; and practical issues during the limitation of treatment. The aim of this article is to address commonly posed questions on these aspects of end‐of‐life care in the intensive care unit, using best available evidence, and provide practical guidance to critical care clinicians in the UK. With the help of case vignettes, we clarify the disassociation of withdrawing and/or withholding treatment from euthanasia; offer practical suggestions for the use of sedation and analgesia around the end of life, dissipating concerns about hastening death; and advocate for the inclusion of family in decision‐making, when the patient does not have capacity. We propose a step‐escalation approach in cases of family conflict and advocate for incorporation of communication skills during medical and nursing training.
LateTriassic A‐type granite boulders in Lower Cretaceous conglomerate of theHida belt, Japan: Their origin and bearing on theYamatotectonic line inFar East Asia
Authors: Isozaki Yukio , Sawaki Yusuke , Iwano Hideki , Hirata Takafumi , Kunugiza Keitaro 
Published: January 2023

AbstractTo identify the origin of the Hida belt in central Japan, geochemistry and U–Pb age of zircons were analyzed for the extra‐large granitoid boulders in the Lower Cretaceous fluvial conglomerate of the Jinzu Group. This study clarified that the boulders of granitoids have geochemistry of typical A‐type granite, as characterized by high Nb + Y and high Ta + Yb values. U–Pb ages of igneous zircons from three individual granite boulders are concentrated at ca. 220 Ma (Late Triassic). As to Late Triassic A‐type granites, there is no corresponding body previously recognized within Japan, whereas identical A‐type granites occur in the eastern Songliao block on the immediate west of the Jiamusi block in NE China. The large size of boulders and the fluvial facies of the hosting conglomerate indicate their origin in the Hida belt per se, suggesting the cryptic and/or past occurrence of A‐type granite, rather than in NE China. Together with the eastern Songliao block (China), Laoelin‐Grodekov (LG) belt (Primorye, Russia), and Yamato Ridge (Japan Sea), the Hida belt forms a unique domain on the immediate west of GSC in Far East Asia, which is characterized commonly by the co‐occurrence of Permo‐Triassic and Jurassic granitoids, and probably with Late Triassic A‐type granite. These confirm that Hida belt represents an allochthonous unit tectonically emplaced onto the rest of Japan, which is composed of the Phanerozoic subduction‐related orogenic belt (Nipponides) developed along the Pacific side of Greater South China (GSC) since the Cambrian. For emphasizing a major geotectonic boundary of the Mesozoic granitoid provinces in Far East Asia, we propose the Yamato tectonic line between the easternmost Central Asian orogenic belt and GSC/Nipponides, which is traced for up to 3000 km from the Russia/China/North Korea border to SW Japan.
Histopathological analysis of chronic paronychia
Authors: Rocha Bruna P. , Verardino Gustavo , Leverone Andreia , D'Almeida Luiza F. V. , Azulay Vitoria , Haneke Eckart , Nakamura Robertha C. 
Published: January 2023

BackgroundChronic paronychia is an inflammatory process of the nail folds lasting more than 6 weeks. Clinically, there is hypertrophy and retraction of the folds and absence of the cuticle. Treatment involves clinical measures and, when there is no response or the hypertrophy of the folds is very pronounced, surgical treatment is indicated. Post‐surgical histopathology is little studied in the literature. In this sense, we believe that the histopathological study is important not only for the individualized understanding of the patient's chronic disease, avoiding relapses, but also for the understanding of its pathophysiology and treatment possibilities.ObjectiveTo describe the histopathological changes found in biopsies of the proximal nail fold of patients with chronic paronychia undergoing surgical treatment.Materials and MethodsA histopathological study of 16 nail folds from 6 patients after surgery was performed at 2 study centers.ResultsThe most prevalent epidermal findings were orthokeratosis, hypergranulosis, acanthosis and spongiosis and the dermal findings were fibrosis and mononuclear inflammatory infiltrate.ConclusionThe histopathological study allowed us to conclude that chronic paronychia is primarily an inflammatory process, but it is not possible to conclude whether microorganisms such as Candida and bacterial cocci are part of the etiology or just secondary and opportunistic agents.
Asymmetric trading responses to credit rating announcements from issuer‐ versus investor‐paid rating agencies
Authors: Nguyen Quan M. P. , Do Hung Xuan , Molchanov Alexander , Nguyen Lily , Nguyen Nhut H. 
Published: January 2023

AbstractThe credit rating industry has traditionally followed the “issuer‐pays” principle. Issuer‐paid credit rating agencies (CRAs) have faced criticism regarding their untimely release of negative rating adjustments, which is attributed to a conflict of interests in their business model. An alternative model based on the “investor‐pays” principle is arguably less subject to the conflict of interest problem. We examine how investors respond to changes in credit ratings issued by these two types of CRAs. We find that investors react asymmetrically: They abnormally sell equity stakes around rating downgrades by investor‐paid CRAs, while abnormally buying around rating upgrades by issuer‐paid CRAs. Our study suggests that, through their trades, investors capitalize on value‐relevant information provided by both types of CRAs, and a dynamic trading strategy taking advantage of this information generates significant abnormal returns.
Targeting therapeutic agent against C3b/C4b, SB002, on the inflammation‐induced bone loss in experimental periodontitis
Authors: Huang Ren‐Yeong , Tseng Fang‐Yi , You Jhong‐Jhe , Van Dyke Thomas E. , Cheng Chia‐Dan , Sung Cheng‐En , Weng Pei‐Wei , Shieh Yi‐Shing , Cheng Wan‐Chien 
Published: January 2023

AbstractAimsTo use experimental periodontitis models in rats to investigate the correlation between local expression of the complement components C3b and C4b in periodontal tissues and disease severity, and to assess the therapeutic effects of targeting C3b/C4b on inflammatory bone loss.Materials and MethodsThe gingival expression of C3, C3b, and C4b in animal experimental periodontitis models were analysed immunohistochemically. The therapeutic effects of the C3b/C4b inhibitor (SB002) on ligation‐induced experimental periodontitis was examined using biochemical, histological, and immunohistochemical analyses.ResultsThe gingival expression levels of C3, C3b, and C4b were positively correlated with the severity of periodontitis. Moreover, both single and multiple injections of the C3b/C4b inhibitor had preventive and therapeutic effects on alveolar bone loss in ligation‐induced experimental periodontitis with no associated adverse consequences.ConclusionsThe association between C3b/C4b and periodontitis may provide a basis for the development of novel therapeutic strategies for periodontitis and other inflammatory diseases.
Praying Truthfully: Sincerity and the Inducing of Belief
Authors: Haruni Michael 
Published: January 2023

ABSTRACTIn a Jewish context, it seems, it is a naïve consensus view that in praying liturgically one aims to express to God, in the manner of ordinary, interpersonal conversation, those thoughts stated by the text. But on this ordinary conversation model (OCM), a problem of insincerity arises when, as commonly happens, the text states a claim the practitioner does not believe. The idea of redeeming one's prayer by reinterpretation is, I argue, incompatible with OCM. Another strategy, which finds some encouragement in Jewish tradition, is to try inducing the missing belief. I further argue, however, that for one's expression of a belief to be proper, in the sense of being authentic, this belief must be corroborated by the evolving, diachronically largely‐coherent understanding distinctive of one's person—a requirement which an induced, otherwise‐missing belief cannot fulfill. This, I suggest, provides some reason to seek a model of liturgical prayer different from OCM.
Psychosocial assessment tools for children and young people aged 5–18 years: A rapid review of the literature
Authors: McLean Karen , O'Connor Elodie , Ong Rachel , Joseph Corey , Skinner Rachel , Goldfeld Sharon 
Published: January 2023

AimSchools are a key platform for health promotion and a point of connection to local health‐care services, with an almost universal reach across the child and adolescent population. This study sought to determine whether validated psychosocial assessment tools exist for a school‐based nursing program that would assist in providing an initial health assessment to identify and understand the needs of children and young people referred to the nurse, with the outcome of appropriate connection to external health and wellbeing services.MethodsRapid evidence assessment methodology was utilised to identify validated tools that could identify psychosocial concerns in children and young people aged 5–18 years. We identified articles from peer‐reviewed journals via three electronic bibliographic databases (PubMed, Embase and CINAHL). We then extended the search for evidence through a search of the grey literature.ResultsFrom 3963 peer‐reviewed articles found in the database search, 10 relevant peer‐reviewed publications met inclusion criteria. In combination with 12 grey literature sources, 33 tools were identified. These included self‐report tools (typically for children aged 11 years and older), parent‐report and teacher‐report tools. We identified the six most promising psychosocial assessment tools. However, there was limited description about implementation within school‐based nursing programs.ConclusionsSeveral tools exist that show promise in assisting school‐based nursing programs to conduct preliminary psychosocial assessments for children and young people. The introduction of any tools into practice would require implementation guidance and evaluation, including how and when they should be used, and when referral and follow‐up is required.