bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences of nurses and midwives with disabilities: A scoping review
Authors: Baker Christine , Malik Gulzar , Davis Jenny , McKenna Lisa 
Published: August 2023

AbstractAimTo identify the extent and type of evidence exploring the workplace experiences of nurses and midwives with disabilities.DesignScoping Review.Data SourcesFour electronic databases were systematically searched in February 2022 to identify studies discussing the experiences of nurses and midwives with disabilities, published between 2012 and 2022. Google Scholar and Theses Global were also searched.Review MethodsAll search results, irrespective of their format, were uploaded to Covidence to assist with the selection of evidence. Studies discussing the experiences of nurses and midwives with disabilities were included. Two reviewers conducted screening and data extraction independently, and a third reviewer resolved conflicts.ResultsSearches identified 130 studies. After screening for title and abstract, full‐text review identified 23 studies for data extraction and analysis. Data were summarized and presented in tabular form under two categories (1) workplace experiences and (2) impact in the workplace. Results were presented in a descriptive, narrative form with accompanying tables.ConclusionThe nurse or midwife can be impacted significantly by disability. Currently, little is known about the workplace experiences of nurses and midwives with disabilities. Therefore, a better understanding of the experiences of the nurse and midwives with disabilities is important to increase diversity, equity, accessibility, and inclusion.ImpactShortage of nurses and midwives worldwide highlights the need to understand why nurses and midwives with disabilities decide to leave the profession. Further research exploring the experiences of nurses or midwives with disabilities will help identify support requirements, develop frameworks for reasonable adjustment accommodations, and assist with future workforce planning.The EQUATOR guidelines for PRISMA have been met.No Patient or Public Contribution.
Histopathological characteristics of the arrhythmogenic right ventricular cardiomyopathy presenting the electrocardiographic characteristics with Brugada syndrome
Authors: Murase Yosuke , Igawa Osamu , Imai Hajime , Ogawa Yasuhiro , Kano Naoaki , Mamiya Keita , Ikeda Tomoyo , Miyamae Kiichi , Yamazoe Shinji , Torii Jun , Yamanaka Kazuyuki , Kato Toshimasa , Kawaguchi Kenta , Kawaguchi Katsuhiro 
Published: August 2023

AbstractIntroductionThe histopathological characteristics of the overlapping disease states of Brugada syndrome (BrS) and arrhythmogenic right ventricular cardiomyopathy (ARVC) have not been fully elucidated.MethodsA 71‐year‐old man showed coved‐type ST‐segment elevation with the right precordial leads, and the echocardiography demonstrated right ventricular (RV) dilatation. After 11 months, he died of a polymorphic VT storm.ResultsThe pathological tissue demonstrated fibrofatty degeneration in the free wall of the RV outflow tract based on the heart autopsy.ConclusionThe overlapping disease states of BrS and ARVC showed histopathological characteristics consistent with ARVC.
SP2‐induced circPUM1 modulates chemoresistance and nature killer cell toxicity in oral squamous cell carcinoma
Authors: Liu Lian , Zou Chen , Lv Xiaozhi , Wei Haigang , Wu Siyuan , Song Jing , Tang Zhe , Luo Hailing , Li Xia , Ai Yilong 
Published: August 2023

AbstractOral squamous cell carcinoma (OSCC) is a type of tumour found in the cavity that is characterized by differentiation and metastasis to the lymph nodes. Although diagnosis strategy and clinical treatment have recently improved, the outcomes for OSCC patients remain unsatisfactory. This study verified the characteristics of circPUM1 in OSCC cells, subsequently generating dysregulated circPUM1 cell models, showing that circPUM1 promoted chemoresistance and natural killer (NK) cell toxicity. Furthermore, the transcription factor SP2 regulated the expression of circPUM1 in OSCC cells, circPUM1 acted as a molecular sponge for miR‐770‐5p. Moreover, Nucleosome Assembly Protein 1 Like 1 (NAP1L1) is a downstream target for miR‐770‐5p and essential for circPUM1‐mediated cisplatin resistance and NK cell cytotoxicity in OSCC cells. The network composed of SP2, circPUM1, miR‐770‐5p and NAP1L1 in OSCC appears to be a promising avenue for the development of novel targets for diagnosing or treating OSCC.
Physiological stress responses of European sea bass Dicentrarchus labrax related to changing operations of floating net cages in intensive farming conditions at the Moroccan M'diq Bay
Authors: Cheyadmi Soumaya , Chadli Housni , El Yamlahi Bouchra , El Maadoudi Mohammed , Cacciola Francesco , Kounnoun Ayoub , Nhhala Hassan , Chairi Hicham 
Published: August 2023

AbstractThe present study aimed to quantify and compare in situ the primary and secondary physiological stress responses, related to the changing operations of floating net cages, in both subadult (523 days post hatching [dph]) and adult (916 dph) European sea bass Dicentrarchus labrax under intensive farming conditions in the Moroccan M'diq Bay. The blood levels of cortisol, glucose, total cholesterol, total protein, and lactate, as well as the percentage of haematocrit, were measured before and after this operation. The results showed significantly elevated levels of cortisol and blood glucose in both age groups, whereas total cholesterol and protein levels were unaffected. In fact, blood lactate significantly decreased in subadults, whereas in adults this parameter was not affected by the operation. However, the haematocrit percentages measured after the operation were significantly higher than those found before the operation in both groups of fish, which is attributed to the increased rate of oxygen renewal in the new net cages and the lower water temperature inside the cages. With regard to the age‐specific response during this essential operation plasma cortisol, blood glucose, and lactate concentrations, as well as plasma total protein levels, were significantly higher in subadults than in adults, in both pre‐ and post‐ stress measurement, with the presence of individual‐specific response. It is concluded that aquaculture practices such as changing the aquaculture net cage could have repercussions in terms of the classic physiological responses to stress in D. labrax.
Dietary patterns in North and South India: a comparison with EAT‐Lancet dietary recommendations
Authors: Ganpule Anjali , Dubey Manisha , Pandey Himanshi , Green Rosemary , Brown Kerry Ann , Srinivasapura Venkateshmurthy Nikhil , Jarhyan Prashant , Maddury Avinav Prasad , Khatkar Rajesh , Prabhakaran Dorairaj , Mohan Sailesh 
Published: August 2023

AbstractBackgroundEnvironmentally sustainable diets are represented in the EAT‐Lancet recommendations developed by the Lancet Commission on Planetary Health in 2019. Very few studies have compared Indian diets with the EAT‐Lancet recommendations. The present study performed such a comparison using primary dietary consumption data from adults in north and south India.MethodsData from 8762 adults (52.4 ± 11.7 years) residing in Sonipat and Vizag India were collected on sociodemographic characteristics, wealth index (household assets) and dietary intake (food frequency questionnaire: nine food groups). The quantity consumed and energy from each food group was compared with the EAT‐Lancet recommendations. We investigated the likelihood of deficit or excess in consumption compared to the EAT‐Lancet recommendations by different sociodemographic factors.ResultsHalf of the participants were women and half resided in rural areas. Vegetables and fruits were consumed in lower quantity, whereas dairy and added fats were consumed in higher quantity than recommended by the EAT‐Lancet recommendations. For whole grains, female gender and poorest wealth index were the factors associated with deficit or no consumption, whereas, for vegetables and fruits, it was poorest wealth index and residence in rural areas (p < 0.05, all). Rural residence and poorest wealth index were associated with excess consumption of dairy and added fats (p < 0.05, all).ConclusionsThe diets of the study participants were mainly plant‐based, and high in dairy but lacking in nutrient‐rich foods such as vegetables and fruits. Appropriate policy actions for making healthy sustainable diets and micronutrient‐rich foods available and affordable to all with a particular focus on the poor and rural populations are warranted.
The multifaceted roles of the brain glycogen
Authors: Markussen Kia H. , Corti Manuela , Byrne Barry J. , Vander Kooi Craig W. , Sun Ramon C. , Gentry Matthew S. 
Published: August 2023

AbstractGlycogen is a biologically essential macromolecule that is directly involved in multiple human diseases. While its primary role in carbohydrate storage and energy metabolism in the liver and muscle is well characterized, recent research has highlighted critical metabolic and non‐metabolic roles for glycogen in the brain. In this review, the emerging roles of glycogen homeostasis in the healthy and diseased brain are discussed with a focus on advancing our understanding of the role of glycogen in the brain. Innovative technologies that have led to novel insights into glycogen functions are detailed. Key insights into how cellular localization impacts neuronal and glial function are discussed. Perturbed glycogen functions are observed in multiple disorders of the brain, including where it serves as a disease driver in the emerging category of neurological glycogen storage diseases (n‐GSDs). n‐GSDs include Lafora disease (LD), adult polyglucosan body disease (APBD), Cori disease, Glucose transporter type 1 deficiency syndrome (G1D), GSD0b, and late‐onset Pompe disease (PD). They are neurogenetic disorders characterized by aberrant glycogen which results in devastating neurological and systemic symptoms. In the most severe cases, rapid neurodegeneration coupled with dementia results in death soon after diagnosis. Finally, we discuss current treatment strategies that are currently being developed and have the potential to be of great benefit to patients with n‐GSD. Taken together, novel technologies and biological insights have resulted in a renaissance in brain glycogen that dramatically advanced our understanding of both biology and disease. Future studies are needed to expand our understanding and the multifaceted roles of glycogen and effectively apply these insights to human disease.image
Treatment of androgenetic alopecia by exosomes secreted from hair papilla cells and the intervention effect of LTF
Authors: Wang Guiyue , Wang Zhili , Zhang Jiaqi , Shen Yan , Hou Xin , Su Lin , Chen Wen , Chen Jiahao , Guo Xiang , Song Hong 
Published: August 2023

AbstractBackgroundAndrogenetic alopecia (AGA) is the most common cause of chronic progressive hair loss in men, and AGA has a severe negative impact on the quality of life and physical and mental health of patients.MethodsFour female C57BL/6 mice were isolated from DP cells in culture (≤4 generations) after stimulation of DPC proliferation by herbal concentrations obtained by the CCK‐8 method, and exosomes were isolated by differential centrifugation at low temperature. Testosterone propionate and topical hair removal treatments were used together to establish the C57BL/6 mouse AGA model, which was treated with LTF, 5% minoxidil, and LTF‐DPC‐EXO, respectively. ELISA was used to detect serum hormone levels, in vivo tracing was used to observe dynamic changes in exosomes, H&E staining showed changes in mouse hair follicle tissue, and (q) RT‐PCR and WB were used to detect dorsal skin VEGF, AKT1, and CASP3 expression in dorsal skin tissues.ResultsHair regeneration was significant in the LTF group, minoxidil group, and LTF‐DPC‐EXO group mice, and the hair growth was only seen in the local skin in the model group. The hormone T in all treatment groups was lower than that in the model group, and e2 was higher than that in the model group. (q) RT‐PCR and western blot showed that VEGF and AKT1 expressions were upregulated and Caspase3 expression was downregulated in the skin sections of mice in the treatment groups.ConclusionDPC‐EXO obtained through LTF may activate AKT1 and VEGF in the PI3K/AKT signaling pathway to inhibit CASP3, thereby protecting DPC to restore the hair growth.
Understanding women's work, children and families during the COVID‐19 global pandemic: Using science to support women around the globe
Authors: Dinella Lisa M. , Fulcher Megan , Weisgram Erica S. 
Published: August 2023

AbstractTimes of disaster disproportionately impact women, children, and vulnerable populations. Thus, concern about women's welfare became paramount as the intensity of the COVID‐19 global pandemic increased. Due to these concerns and the need to examine them from a scientific perspective, we announced a call for empirical and theoretical investigations into how women around the world were experiencing this time of disaster. We were especially interested in investigations that provided information that afforded intersectionality analyses; that is, those that recognized overlapping socially‐constructed systems of oppression such as patriarchy, white supremacy, and classism and how they impact the structures, institutions, agencies, and policies that change women's lives. We received an overwhelming response to our call from scholars around the world whose empirical and theoretical works focused on women's lives during the height of the global COVID‐19 pandemic, resulting in a two‐installment Special Issue on how the COVID‐19 pandemic magnified existing gender inequities. This installment aims to understand how the global pandemic has impacted women's work, children, and families around the world. Throughout both installments, scholars emphasize how empirical findings can and should drive social policies that ameliorate inequities and support women and their families.
Influence of locally delivered doxycycline on the clinical and molecular inflammatory status of intrabony defects prior to periodontal regeneration: A double‐blind randomized controlled trial
Authors: Aimetti Mario , Baima Giacomo , Aliyeva Nargiz , Lorenzetti Virginia , Citterio Filippo , Franco Francesco , Di Scipio Federica , Berta Giovanni N. , Romano Federica 
Published: August 2023

AbstractObjectivesTo test the effect of locally delivered doxycycline (DOX) administered 2 weeks prior to minimally invasive periodontal regeneration in terms of presurgical inflammatory status and cytokine expression profile in the gingival crevicular fluid (GCF). Secondary aim was to assess the early wound healing index (EHI) at 2 weeks after surgery.BackgroundIt is hypothesized that healing after periodontal regeneration is dependent on preoperative soft tissue condition, and that local antibiotics may improve the site‐specific inflammatory status at short time.MethodsSites associated with periodontal intrabony defects requiring regenerative surgery and showing bleeding on probing (BoP) were included. At T0, experimental sites were randomly treated with subgingival instrumentation with or without topic DOX application. After 2 weeks (T1), defects were approached by means of minimally invasive surgical technique. GCF was sampled at both T0 and T1 for inflammatory biomarker analysis. Two weeks after surgery, the EHI was evaluated (T2).ResultsForty‐four patients were included. At T1, the number of BoP+ sites was statistically significantly less in the test group (27.3% vs. 72.7%; p < .01). The total amount of interleukin (IL)‐1β (p < .001), matrix‐metalloproteinases (MMP)‐8 (p < .001), and MMP‐9 (p = .010) in the GCF significantly decreased in the test group at T1, with relevant differences compared to controls. At T2, the EHI had an average value of 1.45 ± 0.86 in the test group while in the control, it was 2.31 ± 1.43 (p = .027). A statistically significantly positive correlation was observed between the amount of IL‐1β and MMP‐9 and EHI scores.ConclusionsWithin the limitations of this study, sites treated with DOX showed improved clinical and molecular inflammatory parameters before surgery, as well as soft tissue healing 2 weeks after surgery.
‘Oh yes, that is also reflection’—Using discursive psychology to describe how GP registrars construct reflection
Authors: Schaepkens Sven P. C. , de la Croix Anne , Veen Mario 
Published: August 2023

AbstractIntroductionLearners in medical education generally perceive that reflection is important, but they also find that reflection is not always valuable or practically applicable. We address the gap between the potential benefits of reflection and its practical implementation in medical education. We examined the perspective of Dutch GP registrars who (must) reflect for their GP specialty training to understand their participant perspective on reflection. Our aim is stimulating alignment between reflective activities that occur in a medical curriculum and the ideals of reflection as a valuable educational activity.MethodsWe conducted, video‐recorded and transcribed seven focus group sessions with GP registrars in 2021 across two Dutch GP educational programmes. We used discursive psychology to analyse the focus group data by focusing on ‘assessments of reflection’. We analysed their discursive features (how something was said) and content features (what was said) and related these to each other to understand how GP registrars construct reflection.ResultsParticipants constructed reflection with nuance; they combined negative and positive assessments that displayed varied orientations to reflection. First, their combined assessments showed complex orientations to norms and experiences with reflecting in practice and that these are not simply negative or positive. Second, GP registrars constructed reflection as a negotiable topic and showed how reflection and its value can be variably understood. Third, through combined assessments, they displayed an orientation to the integration of reflection with other educational tasks, which impacts its value.ConclusionsGenerally, GP registrars speak positively about reflection, but the value of reflection partly depends on its proper integration with other educational tasks. When meaningful integration fails, activities to stimulate reflection can overshoot their own goal and hamper learner motivation to reflect. Developing a healthy ‘reflection culture’ could mitigate some challenges. Therein, reflection is treated as important while learners also have adequate autonomy.
Long‐term follow‐up of allergic bronchopulmonary aspergillosis treated with glucocorticoids: A study of 182 subjects
Authors: Agarwal Ritesh , Sehgal Inderpaul Singh , Muthu Valliappan , Dhooria Sahajal , Prasad Kuruswamy Thurai , Aggarwal Ashutosh Nath , Garg Mandeep , Rudramurthy Shivaprakash M. , Chakrabarti Arunaloke 
Published: August 2023

AbstractBackgroundThe long‐term outcomes of allergic bronchopulmonary aspergillosis (ABPA) are poorly characterised.MethodsWe retrospectively included treatment‐naïve subjects of acute stage ABPA‐complicating asthma from three randomised trials. All the subjects received oral prednisolone for 4 months and were monitored every 6 weeks for 6 months and then every 6 months. Our primary objective was to estimate the incidence rate and the frequency of subjects experiencing ABPA exacerbation. The key secondary objectives were to evaluate the factors predicting ABPA exacerbation and the changes in serum total IgE seen during treatment.ResultsWe included 182 subjects. Eighty‐one (44.5%) patients experienced 120 exacerbations during 512 patient‐years of follow‐up. The incidence rate of ABPA exacerbations was 234/1000 patient‐years. Most (73/81, 90.1%) subjects experienced ABPA exacerbation within three years of stopping therapy. On multivariate logistic regression analysis, peripheral blood eosinophil count ≥1000 cells/μL (adjusted odds ratio [aOR] 2.43; 95% confidence interval (CI), 1.26–4.67), the extent of bronchiectasis (aOR 1.10; 95% CI, 1.03–1.18), age (aOR 0.97; 95% CI, 0.94–0.99), and female sex (aOR 2.16; 95% CI, 1.10–4.24) independently predicted ABPA exacerbation after adjusting for serum total IgE and high‐attenuation mucus. The best cut‐off for serum total IgE after 6 weeks for identifying treatment response and ABPA exacerbations was a 20% decline and a 50% increase, respectively.ConclusionsABPA exacerbations were common within 3 years of stopping treatment. Age, female sex, peripheral blood eosinophilia and the extent of bronchiectasis predicted ABPA exacerbations. The optimal serum total IgE cut‐off for defining ABPA response and exacerbations is a 20% decline and a 50% increase, respectively.
Combination therapy with itraconazole and terbinafine for phaeohyphomycosis caused by Exophiala spinifera: A case report and literature review
Authors: Zhu Xianzhong , Ma Jianchi , Zheng Bowen , Cai Wenying , Li Jiahao , Lin Li , Xi Liyan , Li Xiqing , Lu Sha 
Published: August 2023

AbstractExophiala spinifera is a rare dematiaceous fungus causing cutaneous, subcutaneous and disseminated phaeohyphomycosis (PHM). Standard antifungal therapy for PHM is still uncertain. Here, we report a case of a Chinese male with PHM caused by E. spinifera, who received significant clinical improvement after the treatment with oral itraconazole and terbinafine. With the aim of evaluating the antifungal therapy for PHM caused by E. spinifera, a detailed review was performed.
Development and validation of a multivariable prediction model in pediatric liver transplant patients for predicting intensive care unit length of stay
Authors: Siddiqui Asad , Faraoni David , Williams R. J. , Eytan Danny , Levin David , Mazwi Mjaye , Ng Vicky L. , Sayed Blayne A. , Laussen Peter , Steinberg Benjamin E. 
Published: August 2023

AbstractBackgroundLiver transplantation is the life‐saving treatment for many end‐stage pediatric liver diseases. The perioperative course, including surgical and anesthetic factors, have an important influence on the trajectory of this high‐risk population. Given the complexity and variability of the immediate postoperative course, there would be utility in identifying risk factors that allow prediction of adverse outcomes and intensive care unit trajectories.AimsThe aim of this study was to develop and validate a risk prediction model of prolonged intensive care unit length of stay in the pediatric liver transplant population.MethodsThis is a retrospective analysis of consecutive pediatric isolated liver transplant recipients at a single institution between April 1, 2013 and April 30, 2020. All patients under the age of 18 years receiving a liver transplant were included in the study (n = 186). The primary outcome was intensive care unit length of stay greater than 7 days.ResultsRecipient and donor characteristics were used to develop a multivariable logistic regression model. A total of 186 patients were included in the study. Using multivariable logistic regression, we found that age < 12 months (odds ratio 4.02, 95% confidence interval 1.20–13.51, p = .024), metabolic or cholestatic disease (odds ratio 2.66, 95% confidence interval 1.01–7.07, p = .049), 30‐day pretransplant hospital admission (odds ratio 8.59, 95% confidence interval 2.27–32.54, p = .002), intraoperative red blood cells transfusion >40 mL/kg (odds ratio 3.32, 95% confidence interval 1.12–9.81, p = .030), posttransplant return to the operating room (odds ratio 11.45, 95% confidence interval 3.04–43.16, p = .004), and major postoperative respiratory event (odds ratio 32.14, 95% confidence interval 3.00–343.90, p < .001) were associated with prolonged intensive care unit length of stay. The model demonstrates a good discriminative ability with an area under the receiver operative curve of 0.888 (95% confidence interval, 0.824–0.951).ConclusionsWe develop and validate a model to predict prolonged intensive care unit length of stay in pediatric liver transplant patients using risk factors from all phases of the perioperative period.