bluuebunny/crossref_metadata_2025_split huggingface dataset:
The long‐term effectiveness and cost‐effectiveness of public health interventions; how can we model behavior? A review
Authors: Squires Hazel , Kelly Michael P. , Gilbert Nigel , Sniehotta Falko , Purshouse Robin C. 
Published: September 2023

AbstractThe effectiveness and cost of a public health intervention is dependent on complex human behaviors, yet health economic models typically make simplified assumptions about behavior, based on little theory or evidence. This paper reviews existing methods across disciplines for incorporating behavior within simulation models, to explore what methods could be used within health economic models and to highlight areas for further research. This may lead to better‐informed model predictions. The most promising methods identified which could be used to improve modeling of the causal pathways of behavior‐change interventions include econometric analyses, structural equation models, data mining and agent‐based modeling; the latter of which has the advantage of being able to incorporate the non‐linear, dynamic influences on behavior, including social and spatial networks. Twenty‐two studies were identified which quantify behavioral theories within simulation models. These studies highlight the importance of combining individual decision making and interactions with the environment and demonstrate the importance of social norms in determining behavior. However, there are many theoretical and practical limitations of quantifying behavioral theory. Further research is needed about the use of agent‐based models for health economic modeling, and the potential use of behavior maintenance theories and data mining.
Sociodemographic and obstetric factors associated with health‐related quality of life of high‐risk pregnant women
Authors: Gadelha Ivyna P. , Barros Maria A. R. , de Freitas Bruna B. , de Lima Mesquita Annita , Sales Nirvana M. , Alexandre Camila E. C. , de Oliveira Camila A. N. , Cardoso Alexandrina M. R. , Biazus Dalcin Camila , de S. Aquino Priscila 
Published: September 2023

AbstractObjectiveTo evaluate the association between sociodemographic and obstetric factors and the health‐related quality of life of pregnant women in high‐risk prenatal care.MethodsA cross‐sectional study of women in high‐risk prenatal care in Ceara, Brazil. The investigated outcomes were health‐related quality of life, using the Medical Outcomes Study 36‐item short‐form health survey; the investigated covariates were sociodemographic and obstetric data. Associative analyses were performed using the Jamovi® software version 0.9.ResultsOf the 276 women included in the study, women with the following characteristics presented a better quality of life in some domain of the scale: age equal to or greater than 35 years, higher income per dependent, religious, living with three or fewer persons, with their own home, in primigestation, nulliparous, with no history of previous abortion, and with up to two living children. The regression model showed an association between the total scale score, which means a higher quality of life in women with age equal to or greater than 35 years and a higher income per dependent.ConclusionThe study identified sociodemographic and obstetric factors that may affect the quality of life of high‐risk pregnant women, providing subsidies to health providers so that they can promote better prenatal care.
Top tips for treating the emergency case of Addison's disease
Authors: Spence Susanna , Gunn Eilidh 
Published: September 2023

Background: Although a potentially life‐threatening endocrine emergency, if diagnosed promptly and treated appropriately, the majority of acute Addisonian crises represent very rewarding cases to treat. A complete review of the diagnosis and management of acute and chronic hypoadrenocorticism (including atypical Addison's disease) was published in In Practice (Spence and others 2018).Aim of the article: This article aims to supplement the previously published review with some additional considerations in the management of acute Addisonian crises.
Multimodal label‐free imaging of murine hepatocellular carcinoma with a subcellular resolution
Authors: Chebotarev Artem S. , Ledyaeva Veronika S. , Patsap Olga I. , Ivanov Anatoli A. , Fedotov Andrei B. , Belousov Vsevolod V. , Shokhina Arina G. , Lanin Aleksandr A. 
Published: September 2023

AbstractWe demonstrate label‐free imaging of genetically induced hepatocellular carcinoma (HCC) in a murine model provided by two‐ and three‐photon fluorescence microscopy of endogenous fluorophores excited at the central wavelengths of 790, 980 and 1250 nm and reinforced by second and third harmonic generation microscopy. We show, that autofluorescence imaging presents abundant information about cell arrangement and lipid accumulation in hepatocytes and hepatic stellate cells (HSCs), harmonics generation microscopy provides a versatile tool for fibrogenesis and steatosis study. Multimodal images may be performed by a single ultrafast laser source at 1250 nm falling in tissue transparency window. Various grades of HCC are examined revealing fibrosis, steatosis, liver cell dysplasia, activation of HSCs and hepatocyte necrosis, that shows a great ability of multimodal label‐free microscopy to intravital visualization of liver pathology development.
Electrocardiogram Changes Following Intravenous Bisphosphonate Infusion: A Systematic Review and Meta-Analysis
Authors: Shoung Alex , Shoung Nicholas , Hii Rachael , Nerlekar Nitesh , Ebeling Peter R , Rodríguez Alexander J 
Published: September 2023

ABSTRACT
Bisphosphonates are first-line treatments for several bone and mineral disorders. Studies have reported an increased incidence of serious atrial fibrillation in patients receiving bisphosphonates; however, uncertainty remains as to whether electrical disturbances are precipitated by bisphosphonates. We aimed to review the literature for studies reporting electrocardiogram (ECG) findings in patients receiving intravenous bisphosphonates for any indication. We searched MEDLINE and EMBASE from inception until January 14, 2023, for studies reporting ECG parameters after intravenous bisphosphonate infusion. We excluded studies that only reported atrial fibrillation. Study quality was assessed using the Newcastle-Ottawa scale. Continuous data were meta-analyzed if reported in at least two studies. Random-effects models were fitted and reported as standardized mean difference (SMD) with 95% confidence intervals (95% CIs). We found 1083 unique records, of which 11 met our inclusion and exclusion criteria. Studies had a low to low/moderate risk of bias. Six prospective cohort studies were included in the meta-analysis. Five studies used zoledronic acid, whereas one study used pamidronate. Most studies (n = 4) were conducted in postmenopausal women with osteoporosis, one study was conducted in patients with bone metastases, and one study in children with osteoporosis secondary to cerebral palsy. Study populations ranged from n = 15 to n = 116. Heart rate–corrected QT (QTc) was significantly longer post-infusion (SMD = 0.46 ms [95% CI 0.80 to 0.11]; n = 67 patients, k = 2 studies, τ2 = 0). There were no differences in heart rate, P wave (maximum), P wave (minimum), P wave dispersion, PR interval, QRS duration, QTc, QTc (maximum), QTc (minimum), and QTc dispersion. The correlation between pre- and post-infusion QTc was not significant (p = 0.93). Overall, there is a weak association between intravenous bisphosphonate infusion and a QTc interval prolongation. However, there is insufficient evidence to support an association between intravenous bisphosphonate and any ECG variable changes, which may precipitate atrial fibrillation. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Diminazene aceturate‐induced cytotoxicity is associated with the deregulation of cell cycle signaling and downregulation of oncogenes Furin, c‐MYC, and FOXM1 in human cervical carcinoma Hela cells
Authors: Gharbaran Rajendra , Sayibou Zouberou , Atamturktur Seher , Ofosu‐Mensah Jeithy Jason , Soto John , Boodhan Nicholas , Kolya Saaimah , Onwumere Onyekwere , Chang Lynne , Somenarain Latchman , Redenti Stephen 
Published: September 2023

AbstractDiminazene aceturate (DIZE) is an FDA‐listed small molecule known for the treatment of African sleeping sickness. In vivo studies showed that DIZE may be beneficial for a range of human ailments. However, there is very limited information on the effects of DIZE on human cancer cells. The current study aimed to investigate the cytotoxic responses of DIZE, using the human carcinoma Hela cell line. WST‐1 cell proliferation assay showed that DIZE inhibited the viability of Hela cells in a dose‐dependent manner and the observed response was associated with the downregulation of Ki67 and PCNA cell proliferation markers. DIZE‐treated cells stained with acridine orange‐ethidium and JC‐10 dye revealed cell death and loss of mitochondrial membrane potential (Ψm), compared with DMSO (vehicle) control, respectively. Cellular immunofluorescence staining of DIZE‐treated cells showed upregulation of caspase 3 activities. DIZE‐treated cells showed downregulation of mRNA for G1/S genes CCNA2 and CDC25A, S‐phase genes MCM3 and PLK4, and G2/S phase transition/mitosis genes Aurka and PLK1. These effects were associated with decreased mRNA expression of Furin, c‐Myc, and FOXM1 oncogenes. These results suggested that DIZE may be considered for its effects on other cancer types. To the best of our knowledge, this is the first study to evaluate the effect of DIZE on human cervical cancer cells.
Inhibition of annexin A7 suppresses senescence‐associated heterochromatin foci formation and senescence through the AMPK/mTOR pathway in human dermal fibroblasts
Authors: Li Nan , Yan Xiaomeng , Cui Xiaoling , Zhao Congyao , Lin Zhaomin , Miao Junying 
Published: September 2023

AbstractSenescence‐associated heterochromatin foci (SAHF) is often used as a biological marker for senescent cells, but the regulation of its formation process is unclear. To find a new modulator of SAHF, we screened our chemical small molecules and found 7‐amino‐2,3,4,5‐tetrahedrobenzo[b][1,4] oxazepin‐3‐ol (ABO) that was identified as an inhibitor of annexin A7 GTPase (ANXA7) dramatically suppressed the aggregation of heterochromatin protein (HP1γ), an indicator of SAHF. To understand its action mechanism, we first observed the changes in the karyoplasmic ratio of ANXA7 because HP1γ mainly located in the nucleus. The results showed that ABO elevated the protein level of ANXA7 in the nucleus. Therefore, we raised a hypothesis that ANXA7 interacted with HP1γ and regulated its phosphorylation, which is closely related to the formation of SAHF. The co‐immunoprecipitation and Western blot experiment results showed that ANXA7 had no direct interaction with HP1γ, however, the phosphorylation of HP1γ was increased by ABO, which suggested that ANXA7 indirectly regulated HP1γ phosphorylation. Then, based on our previous discovery of ANXA7 interacting with AMP‐activated protein kinase (AMPK), we investigated the effect of the AMPK/mammalian target of rapamycin (mTOR) signaling pathway on ABO‐increased phosphorylation of HP1γ. We found that ABO decreased AMPK phosphorylation and increased the phosphorylation level and activity of mTOR. In the presence of an AMPK activator or mTOR inhibitor, ABO could not increase HP1γ phosphorylation. As a result, ABO inhibited the senescence of human dermal fibroblasts (HDFs). In this study, we found that ANXA7 was a new regulator of SAHF, it could regulate the formation of SAHF through the AMPK/mTOR pathway. The data suggested that ABO could be used as a powerful tool to inhibit the replicative senescence of HDFs.
Can rounding up price discounts reduce sales?
Authors: Jha Subhash , Biswas Abhijit , Guha Abhijit , Gauri Dinesh 
Published: September 2023

AbstractSome retailers round up price discounts, such as displaying a 7.7% discount as an 8% discount. In such instances, lay beliefs would suggest that displaying an 8% discount (vs. a 7.7% discount) would increase purchase intentions. In this research report, however, we show that displaying a rounded‐up, higher‐value discount (8%) versus a more precise but lower‐value discount (7.7%) reduces purchase intentions. Specifically, we show that using a more precise discount framing increases perceptions that the discount duration is shorter, in turn increasing purchase intentions. This research report presents a relevant and counterintuitive effect, and we propose contributions to work on both behavioral pricing and numerical information processing. Furthermore, this work has implications for practice, showing how to optimally display price discounts.
Adsorption and photoactivity performances of copper(II)–benzene‐1,3,5‐tricarboxylate (Cu‐BTC) and zeolitic imidazolate framework (ZIF‐8): effect of humidity
Authors: Tuncel Duygu , Ökte A Neren 
Published: September 2023

AbstractBACKGROUNDIn this study, adsorption properties and photocatalytic activities of Cu‐BTC and ZIF‐8 are explored using an anionic dye, methyl orange (MO), and a cationic dye, methylene blue (MB). Effect of humidity on the stabilities and performances of Cu‐BTC and ZIF‐8 is controlled under 40%, 67% and 84% relative humidity (RH) conditions. Cu‐BTC, ZIF‐8 and humidified samples are characterized by various techniques.RESULTSHumidified samples do not exhibit new X‐ray diffraction (XRD) peaks and significant variations in scanning electron microscopy images and UV–visible diffuse reflectance (UV–Vis DRS) spectra. After degradation experiments, XRD, X‐ray photoelectron spectra and UV–Vis DRS confirm the coexistence of Cu1+ and Cu2+ in Cu‐BTC and the formation of ZnO in ZIF‐8. Reduction in surface area measurements and detection of N and S signals in energy‐dispersive X‐ray analysis prove interaction of MO and MB. Adsorptions of MO and MB are proposed via electrostatic attraction, π–π interaction and hydrogen bonding and conform to pseudo‐second‐order kinetics. Langmuir and Freundlich models describe the adsorption isotherms of MO and MB. Ligand‐to‐metal charge transfer process is principally responsible for the photoactivities of Cu‐BTC and ZIF‐8. Cu‐BTC (84% RH) and ZIF‐8 (84% RH) exhibit the highest performances, following Langmuir–Hinshelwood kinetics. Stability tests of Cu‐BTC, ZIF‐8 and humidified samples imply their reuse abilities.CONCLUSIONThis study correlates structural characteristics and adsorption abilities/photocatalytic performances of Cu‐BTC and ZIF‐8. Results may offer new ideas for the improvement of metal–organic frameworks as adsorbents and photocatalysts. © 2023 Society of Chemical Industry.
Improved sensitivity and specificity for citrin deficiency using selected amino acids and acylcarnitines in the newborn screening
Authors: Kido Jun , Häberle Johannes , Tanaka Toju , Nagao Masayoshi , Wada Yoichi , Numakura Chikahiko , Bo Ryosuke , Nyuzuki Hiromi , Dateki Sumito , Maruyama Shinsuke , Murayama Kei , Yoshida Shinichiro , Nakamura Kimitoshi 
Published: September 2023

AbstractCitrin deficiency is an autosomal recessive disorder caused by a defect of citrin resulting from mutations in the SLC25A13 gene. Intrahepatic cholestasis and various metabolic abnormalities, including hypoglycemia, galactosemia, citrullinemia, and hyperammonemia may be present in neonates or infants in the “neonatal intrahepatic cholestasis caused by citrin deficiency” (NICCD) form of the disease. Because at present, newborn screening (NBS) for citrin deficiency using citrulline levels in dried blood spots (DBS) can only detect some of the patients, we tried to develop a new evaluation system to more reliably detect newborns with citrin deficiency utilizing parameters already in place in present NBS methods. To achieve this goal, we re‐analyzed NBS profiles of amino acids and acylcarnitines in 96 NICCD patients, who were diagnosed through selective screening or positive family history. Hereby, we identified the combined evaluation of arginine (Arg), citrulline (Cit), isoleucine+leucine (Ile + Leu), tyrosine (Tyr), free carnitine (C0) / glutarylcarnitine (C5‐DC) ratio in DBS as potentially sensitive to diagnose citrin deficiency in pre‐symptomatic newborns. In particular, a scoring system using threshold levels for Arg (≥9 μmol/L), Cit (≥ 39 μmol/L), Ile + Leu (≥ 99 μmol/L), Tyr (≥ 96 μmol/L) and C0/C5‐DC ratio (≥327) was significantly effective to detect newborns who later developed NICCD, and could thus be implemented in existing NBS programs at no extra analytical costs whenever citrin deficiency is considered to become a novel target disease.
Free‐Breathing Compressed Sensing Cine Cardiac MRI for Assessment of Left Ventricular Strain by Feature Tracking in Children
Authors: Xu Ke , Xu Rong , Xu Hua‐yan , Xie Lin‐jun , Yang Zhi‐gang , Fu Hang , Bai Wei , Zhang Lu , Zhou Xiao‐yue , Guo Ying‐kun 
Published: September 2023

BackgroundCardiac MRI feature‐tracking (FT) with breath‐holding (BH) cine balanced steady state free precession (bSSFP) imaging is well established. It is unclear whether FT‐strain measurements can be reliably derived from free‐breathing (FB) compressed sensing (CS) bSSFP imaging.PurposeTo compare left ventricular (LV) strain analysis and image quality of an FB CS bSSFP cine sequence with that of a conventional BH bSSFP sequence in children.Study TypeProspective.Subjects40 children able to perform BHs (cohort 1 [12.1 ± 2.2 years]) and 17 children unable to perform BHs (cohort 2 [5.2 ± 1.8 years]).Field Strength/Sequence3T, bSSFP sequence with and without CS.AssessmentAcquisition times and image quality were assessed. LV myocardial deformation parameters were compared between BH cine and FB CS cine studies in cohort 1. Strain indices and image quality of FB CS cine studies were also assessed in cohort 2. Intraobserver and interobserver variability of strain parameters was determined.Statistical TestsPaired t‐test, Wilcoxon signed‐rank test, intraclass correlation coefficient (ICC), and Bland–Altman analysis. A P‐value <0.05 was considered statistically significant.ResultsIn cohort 1, the mean acquisition time of the FB CS cine study was significantly lower than for conventional BH cine study (15.6 s vs. 209.4 s). No significant difference were found in global circumferential strain rate (P = 0.089), global longitudinal strain rate (P = 0.366) and EuroCMR image quality scores (P = 0.128) between BH and FB sequences in cohort 1. The overall image quality score of FB CS cine in cohort 2 was 3.5 ± 0.5 with acquisition time of 14.7 ± 2.1 s. Interobserver and intraobserver variabilities were good to excellent (ICC = 0.810 to 0.943).Data ConclusionFB CS cine imaging may be a promising alternative technique for strain assessment in pediatric patients with poor BH ability.Level of Evidence1Technical EfficacyStage 1
Evaluation of Social Determinants of Health on Dysphagia Care Pathways at a Tertiary Care Facility
Authors: Zagloul Maie M. , Bock Jonathan M. , Blumin Joel H. , Friedland David R. , Adams Jazzmyne A. , Tong Ling , Osinksi Kristen I. , Khani Masoud , Luo Jake 
Published: September 2023

ObjectivesLimited research exists evaluating the impact of social determinants of health in influencing care pathways for patients with dysphagia. A better understanding of whether these determinants correlate to altered care and resource utilization is essential as it relates to patient outcomes.Study DesignRetrospective chart review.MethodsAll adult patients seen at a tertiary midwestern hospital were screened for ICD codes of dysphagia diagnoses from 2009 to 2019. Demographic information was collected from these patients with dysphagia including sex, race, ethnicity, and insurance status. Subgroup analysis was performed to assess referral pattern rates and types of diagnostic interventions ordered (none, videofluoroscopic swallow study, esophagram, and esophagogastroduodenoscopy).ResultsA total of 31,858 patients with dysphagia were seen at our institution during the study period, with a majority being female (56.36%), Caucasian (79.83%), and publicly insured (63.16%), at a median age of 60.35 years. There were no significant care delivery pattern differences based on geography/zip code analyses. African American patients were significantly more likely to have imaging or interventions performed (odds ratio [OR] 1.463, p = 0.005). Patients with public insurance also had higher rates of diagnostic study utilization (OR 1.53, p = 0.01). Only 3% of all patients with dysphagia were seen by laryngologists.ConclusionNo significant differences were seen in dysphagia evaluation modalities based on zip code analyses surrounding this tertiary care facility. African American patients and those with public insurance had significantly higher utilization of subsequent testing and intervention for dysphagia care. Further studies are necessary to delineate causes and outcome differences for these measurable differences in dysphagia care pathways.Level of Evidence4 Laryngoscope, 134:1139–1146, 2024
Higher alpha and gamma, but not beta diversity in tropical than in Mediterranean temporary ponds: A multi‐taxon spatiotemporal approach
Authors: Gálvez Ángel , Castillo‐Escrivà Andreu , Magurran Anne , Alambiaga Iván , Bonilla Fabián , Camacho Antonio , García‐Roger Eduardo M. , Iepure Sanda , Miralles‐Lorenzo Javier , Monrós Juan S. , Olmo Carla , Picazo Antonio , Rojo Carmen , Rueda Juan , Sasa Mahmood , Segura Mati , Armengol Xavier , Mesquita‐Joanes Francesc 
Published: September 2023

AbstractThe latitudinal diversity gradient predicts that tropical regions should have higher alpha, beta, and gamma diversity than temperate areas. However, only a few studies have assessed the temporal variability of the different components of diversity across climatic regions. In this study, we compare, using a spatial and temporal approach, the diversity of multiple taxa inhabiting tropical and Mediterranean temporary ponds. We sampled the biological communities of each set of ponds on three occasions during the same hydrological year. Under a spatial framework, we analyzed, alpha, beta, and gamma diversities. With a temporal approach, we compared the coefficients of variation in alpha diversity for each local community, and temporal beta diversity. Differences between regions and sampling periods were tested using generalized linear mixed models. We found higher gamma and alpha diversity in the tropical ponds, as expected given the latitudinal differences between them. However, phytoplankton and microinvertebrates from the Mediterranean region, matched or even exceeded tropical alpha diversity on some occasions. Spatial beta diversity did not differ between regions, and it showed lower values at the middle or the end of the hydroperiod in bacteria, micro‐ and macroinvertebrates and amphibians. Thus, processes homogenizing and heterogenising pond metacommunities must be balanced in both studied regions. Temporal variation in alpha and beta diversity was similar for ponds in both regions, except for macroinvertebrates and amphibians, suggesting differential effects on community variation observable only in animals with longer life‐spans, at our temporal scale of analysis.