bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term outcome and quality of life of patients with subarachnoid hemorrhage admitted to intensive care unit: a single-center retrospective study
Authors: Bergamini Carlo , Brogi Etrusca , Salvigni Sara , Romoli Michele , Bini Giovanni , Venditto Alessandra , Lafe Elvis , D’Andrea Marcello , Tosatto Luigino , Ruggiero Maria , Agnoletti Vanni , Russo Emanuele 
Published: June 2023

Abstract
Patients admitted to intensive care unit (ICU) after non-traumatic subarachnoid hemorrhage (SAH) represent a group with distinctive characteristics and few data are available on long-term outcome in this population.
We conducted a retrospective study in an Italian intensive care unit. All patients with non-traumatic SAH (ICD-9-CM Diagnosis Code 430) admitted to ICU were included. Disability and quality of life were evaluated via telephone interview after 12-15 months after initial bleeding using GOSE and EuroQoL, respectively. Baseline and clinical course characteristics were analyzed to evaluate relation with poor outcome defined as GOSE ≤ 3. Final population consisted of thirty-eight patients.
Twenty-four patients (63.2%) had favourable outcome (GOSE ≥ 4).
Among 29 patients (76.3%) who survived at 1-year, median EQ-5D Index was 0.743 (IQR 0.287), while median EQ-VAS was 74.79 (IQR 18.5). Median EQ-5D Index and median EQ-VAS were higher among patients with favorable outcome (EQ-5D Index p=0.037, EQ-VAS p=0.003). Among baseline characteristics, only HH scale showed a significant relation with disability at one year (p=0.033). Between complications occurred during ICU-stay only early HICP was related with unfavourable outcome (p=0.028).
Higher HH scale and early HICP were related with unfavourable outcome. Among patients with unfavourable outcome, quality of life has a broad range of variability and this result should be taken into account when reporting patient-centred outcomes.
Optimizing the Extraction of Antioxidant Components from Grape (Vitis vinifera L.) Skin by Ultrasonic Pre-treatment in Response Surface Method
Authors: Azizi Saadat , Nazari Seyyed Moein , MoradiHaghgou Leila 
Published: June 2023

Abstract

Grapes are one of the most important agricultural products which could be used either as fresh fruit or processed food. In Iran, grapes are very crucial agricultural and commercial products. Every year, a massive volume of grapes waste is made by the units of grape Doshab producers, so the producers are engaging with many problems of waste disposal. Grapes waste is a valuable source of natural pigment and antioxidant compounds specifically polyphenols compounds. Extracting antioxidant compounds from cheap primary materials like grapes waste is a suitable method for various food and pharmaceutical industries. This research aims to find the optimum state of extracting phenolic compounds from Shani grapes skin with 3 independent variables (extraction time using ultrasonic bath, liquid to solid phase ratio and ethanol solvent concentration), by utilizing the response surface method (RSM), and central composite design (CCD). The optimum condition for extraction of this compound was 59.06% concentration of ethanol, 16.08 ml/g liquid to solid phase ratio and 24.12 min extraction time. The phenolic compounds concentrations were measured by high-performance liquid chromatography (HPLC). The research results have shown that the extract of Shani grapes skin contains 8 different phenolic compounds, of which, epigallocatechin and catechin had the highest concentration. Consequently, by finding the optimum condition of phenolic compounds extraction, these compounds could be produced on a pilot scale for utilization in the food and pharmaceutical industries.
Korean women’s experiences of traumatic childbirth: A qualitative descriptive study
Authors: Yeo Jung Hee , Sagong Hae 
Published: June 2023

Abstract
Background
Previous studies have established that negative or traumatic childbirth can create childbirth-related post-traumatic stress disorder (CB-PTSD). Because of the negative implications of CB-PTSD for mothers, children, and families, global qualitative research on traumatic or negative childbirth experiences has risen in recent years. However, few studies have been conducted in South Korea. This study aims to explore women’s experiences of traumatic childbirth in South Korea.
Methods
This qualitative descriptive study examined nine women who were in the high-risk group of PTSD (IES-R-K > 24) at the time of the interview, between 1–11 years after childbirth. Semi-structured interviews were conducted. Interview transcripts were subjected to thematic analysis.
Results
The analysis identified two themes with six subthemes, as follows: 1) person-centred factors (pain, guilt, and threatened dignity); 2) society-centred factors (damaged femininity, confusion in social relationships, and maternal identity conflict). These findings may be attributed to Korean culture (excessive motherhood and lookism), as well as unbearable pain, disrespectful childbirth environments, lack of spouse’s support, loss of their lifestyle, and unrealistic expectations.
Conclusions
This study demonstrates various negative consequences, ranging from psychological damage to conflict in women’s relationships with their spouses, colleagues, and children. This highlights the severity of the birth experience, which can be traumatic, and the need for clinical intervention. Therefore, healthcare professionals' greater understanding of women’s experiences and increased concern about childbirth and respectful birthing environments are required. In addition, based on our findings, there is a need to develop interventions that can alleviate CB-PTSD and further improve women’s mental health, particularly through women-centred interventions.
Sensitivity of Mesoscale Modeling to the
Resolution of Urban Morphological Feature
Inputs: Implications for Characterizing
Urban Sustainability
Authors: Sweet-Breu Levi , Brelsford Christa , Wang Linying , New Joshua , Bass Brett , Allen-Dumas Melissa 
Published: June 2023

Abstract

As the numerical weather prediction community seeks deeper understanding of multi-scale interactions among the atmosphere, human systems and the overall earth system, more explicit representation of surface terrain in these models has become necessary. While a great body of work has examined the differences in error and uncertainty of simulations at various horizontal grid resolutions, no studies have been performed that compare the results of running the models at the same horizontal grid resolution but with different resolutions of embedded urban neighborhood morphology. We examine the differences in meteorological output from the Weather Research and Forecasting (WRF) model run at 270m horizontal resolution using 10m, 100m and 1 km resolution neighborhood morphological inputs and with no morphological inputs. We find that horizontal resolution differences in urban morphological inputs to numerical weather models result in model output differences, especially in the spatial variability of meteorological parameters. We show that these results affect how we determine the heterogeneity of human vulnerability to a heat wave across an urban area.
Toxicological and histopathological alterations in the heart of young and adult albino rats exposed to mosquito coil smoke.
Authors: Abdrabouh Abeer El-Said 
Published: June 2023

Abstract

Mosquito coil repellents are well known indoor air pollutant with significant health concerns. The present study investigated the toxic effects of mosquito coil smoke on the heart of young and adult male rats. The animals were subjected to the smoke for 6 hours/day, 6 days/week, for 4 weeks. Within the first hour after lighting the coil, significant amounts of formaldehyde, total volatile organic compounds, and particulate matter (PM2.5 & PM10) were detected. Both exposed ages; particularly the young group, showed a significant increase in the activities of serum aspartate aminotransferase, lactate dehydrogenase, creatine kinase-MB, and the levels of troponin I, myoglobin, Na+levels, lipid profile, and inflammatory markers (interleukin-6 and C-reactive protein) as well as a significant decrease in K+levels and cardiac Na-K ATPase activity indicating development of cardiac inflammation and dysfunction. Furthermore, the toxic stress response was validated by significant downregulation at expression of the detoxifying enzyme cytochrome p450. Histopathological studies in both age groups, especially the young group, revealed cardiomyocytes degeneration, necrotic areas, and extensive collagen deposition in heart tissue. Myocardial dysfunction was furtherly confirmed by the histochemical findings of reduced glycogen and protein contents, and upregulation at the pro-apoptotic markers P53, cytochrome C and caspase-3 expressions as detected by immunohistochemical approach in heart sections of the exposed groups. Finally, the myocardial dysfunctional effects of the coil active ingredient, meperfluthrin, was confirmed by the docking results which indicated a high binding affinity of meperfluthrin, with Na-K ATPase and caspase-3. In conclusion, both the young and adult exposed groups experienced significant cardiac toxicity changes evidenced by cell apoptosis and histopathological alterations as well as, disruption of biochemical indicators.
Characteristics of Female genital mutilation and Sexual Function among Circumcised women in Sardasht (Iran) in 2023
Authors: Hassannejhad Kosar , Monir Firouzeh Asadzadeh , Iranpour Sohrab , Rabiepour Soheila , Akbari Pouran Akhavan 
Published: June 2023

Abstract
Background
Female genital mutilation (FGM/C) is recognized internationally as a violation of the human rights of girls and women, which has many sexual, physical, and psychological consequences. The present study was conducted to investigate the characteristics of Female genital mutilation and Sexual Function among circumcised women in Sardasht City in Iran.
Methods
In this present cross-sectional study a total of 197 mutilated women entered the study by simple random sampling from two healthcare centers in Sardasht, Iran. First, a genital examination was done by a gynecologist to determine the type of FGM/C/C in women, then the checklist of FGM/C characteristics and FSFI questionnaire were completed for them. Data were analyzed using SPSS 23 software.
Results
Type I and II of FGM/C/C were performed in 73.1 and 26.9 percent of the participants, respectively. The age range of performing FGM/C/C (68.5%) was 4–10 years old, and the most common reason for it in 69% was reported cultural tradition. All cases of FGM/C/C were performed by traditional local female circumcisers without the use of anesthesia. The average score of sexual function index (FSFI) in 99% of circumcised women was below 28 and they were screened as sexual dysfunction. The average score of FSFI in type I and II of FGM/C was 23.5 ± 2.0 and 17.4 ± 2.39, respectively, which indicates more severe sexual dysfunction in women with type II. In all domains of FSFI, women with type II of FGM/C/C obtained lower scores than women with type 1.
Conclusion
Sexual dysfunction is common in women who have been under genital mutilation, and its severity is related to the type of FGM/C/C. Considering the impact of female genital mutilation on sexual function, increasing awareness among people to prevent this practice is one of the health priorities in areas with a culture of FGM/C/C.
WITHDRAWN: Assessing Equity in Unmet Needs for Non-Communicable Diseases Services in Saudi Arabia Using a National Household Survey (2019)
Authors: Alattas Maha , Gordon Sarah , Sabin Lora L. , El-jardali Fadi , Wirtz Veronika J. 
Published: June 2023

Abstract

Background: Saudi Arabia is implementing a comprehensive health system transformation in health services provision, governance, and financing that was announced in 2016. Given the high burden of non-communicable diseases (NCDs), a key objective of the transformation is to integrate NCD prevention and treatment into primary care. The study objectives are to assess primary care service use for treatment of NCDs, to quantify existing inequities in preventive services utilization, and to identify regional and socioeconomic factors associated with these inequities.
Methods:
Using the 2019 Kingdom of Saudi Arabia World Health Survey, multivariable logistic regression models were conducted to identify significant predictors of utilization of primary care services for prevention and treatment of NCDs, unmet health care needs among those who reported a diagnosis of diabetes, hypertension, or dyslipidemia, and breast and cervical cancer screenings.
Results:
Among those who reported having an NCD diagnosis, living in a high-income household was associated with a lower probability of having an unmet need in comparison to those living in lower-income households. Furthermore, adults residing in rural areas were less likely to have an unmet need compared to residents in urban areas (OR 0.58, p=0.029). Not perceiving a need for healthcare within the last 12 months was associated with three times the probability of unmet need in comparison to those with a subjective need for healthcare (p<0.001). All regions had lower probability of ever having a mammogram when compared to the central regions around Riyadh. Women who had more than a secondary level of education had five times the odds of undergoing cervical cancer screening and three times the likelihood of ever having a mammogram (P=0.012, p=0.02). Middle (OR 1.99, P=0.026), upper middle (OR 3.47, p<0.001), and high-income households (OR 2.59, p<0.001) had increased probability of having a cervical cancer screening compared to lower-income households.
Conclusions: Inequities in NCD treatment and prevention services’ utilization in Saudi Arabia are strongly associated with region of living, population density, wealth, income, education and perceived need for health care. More research is needed to better understand the extent of unmet primary care needs for NCD and how to address the underlying contributing factors to access inequities.
Effect of symptomatic rate on spreading of COVID-19 evaluated by a flexible compartment model
Authors: Ohmori Hiroo 
Published: June 2023

Abstract
For COVID-19, many of the infected individuals become symptomatic after the latent period is ended and should be isolated from the community. After the isolation period is ended, they become recovered individuals who have immunity and return to the community. Thus, they are capable of infecting susceptible individuals only during the latent period. Some infected individuals, however, are asymptomatic through the recovery period, which includes the latent period. They are infectious but not isolated. They stay in the community and continue infecting susceptible individuals through the recovery period, inducing an increase in the number of infected individuals, though they become recovered individuals who also have immunity in the community after the recovery period is ended. The number of ‘symptomatic and isolated’ infected individuals and/or of ‘asymptomatic and staying’ infected individuals is controlled by the symptomatic rate. Thus, the symptomatic rate affects the number of infectious individuals continuing to infect susceptible individuals in the community. At the same time, the symptomatic rate affects the number of isolated individuals and, as a result, the number of recovered individuals and the population excluding the individuals kept in isolation. Since the contact rate between infected individuals and susceptible individuals is affected by both the number of recovered individuals having returned to the community and the population excluding the individuals kept in isolation, the symptomatic rate also affects the contact rate. Namely, the symptomatic rate affects not only the number of infectious individuals but also the contact rate. This symptomatic rate could change commonly depending on the characteristics of virus and/or on the health conditions of infected individuals. However, the symptomatic rate could be changed/decided in the middle of infection duration by political and/or medical interventions because the symptomatic rate practically means the isolation rate, and the isolation rate and/or the number of isolated individuals could be decided by some political and/or medical interventions induced by, for example, the capacity of hospital care. Therefore, the evaluation of the effect of the symptomatic rate could provide reference materials for political and/or medical measures. The effects of vaccination and isolation by PCR were also examined for cases with different symptomatic rates. The results of evaluation by a flexible compartment model, which is a model including the symptomatic rate as a term in the calculation equation and being able to evaluate the effect of isolated/recovered individuals on the spread of COVID-19, show that a small difference in the symptomatic rate causes a large difference in the number of infected individuals and in the infection duration. Vaccination and PCR tests were effective in reducing the number of infected individuals for cases with any symptomatic rates.
Etoposide plus cytarabine versus cyclophosphamide or melphalan in busulfan-based preparative regimens for autologous stem cell transplantation in adults with acute myeloid leukemia in first complete remission: A study from the Acute Leukemia Working Party of the EBMT
Authors: Labopin Myriam , Pabst Thomas , Versluis Jurjen , Gorkom Gwendolyn Van , Meijer Ellen , d.y Tobias Gedde-Dahl , Arcese William , Montoro Juan , Pérez-Simón José A , Schaap Nicolaas , Maertens Johan , Vrhovac Radovan , Lanza Francesco , Gorin Norbert , Mohty Mohamad , Ciceri Fabio , Sanz Jaime 
Published: June 2023

Abstract

IntroductionHigh-dose myeloablative chemotherapy followed by autologous stem cell transplantation (ASCT) is a valid treatment option for patients with acute myeloid leukemia (AML) in first complete remission (CR1). However, information on specific conditioning regimens is scarce. The ALWP showed improved outcomes with busulfan and high-dose melphalan (BUMEL) conditioning compared to busulfan with cyclophosphamide (BUCY) in high-risk patients. The combination of more AML directed drugs using high-dose cytarabine, etoposide and busulfan (BEA) has been the recommended regimen in subsequent PETHEMA studies.MethodsIn order to analyse the impact of the conditioning regimen we retrospectively compared the outcome of adult patients with AML in CR1 that received an ASCT from 2010 to 2021 with either BEA, BUCY or BUMEL registered in the EBMT database.ResultsOverall 1560 patients underwent ASCT at a median age of 52 years (range, 18–75). Eight hundred and forty-three (54%) were male. Two hundred and sixty-seven (23%), 815 (70%) and 75 (7%) had favorable-, intermediate- and adverse-risk cytogenetics, respectively (data not reported for 403 patients). FLT3-ITD and NPM1 mutations were present in 177 (23%) and 481 (58%) patients, respectively. Regarding conditioning, 156, 1143 and 261 received BEA, BUCY and BUMEL, respectively. Compared to BUCY and BUMEL, BEA patients were younger (p < 0.001) and less frequently had NPM1 mutations (p = 0.03). Transplant outcomes at 5 years with BEA, BUCY and BUMEL were: cumulative incidence of relapse 41.8%, 46.6% and 51.6%; non-relapse mortality (NRM) 1.5%, 5.2% and 7.3%; probability of leukemia-free survival (LFS) 56.7%, 48.2% and 41.1%; and overall survival (OS) 71.3%, 62.3% and 56%, respectively. In multivariable analysis the BEA regimen showed significant improvement in OS compared to BUCY (hazard ratio [HR] 0.65; 95% CI, 0.42–0.83; p = 0.048) and BUMEL (HR 0.59; 95% CI, 0.37–0.94; p = 0.029). Favorable cytogenetics and younger age were also associated with improved OS.ConclusionsHigh-dose myeloablative combination chemotherapy with BEA offered improved outcomes compared to classical BUCY or BUMEL in patients with AML in CR1 undergoing ASCT.
Mapping of a novel recessive brown planthopper resistance gene bph46 from wild rice (Oryza nivara)
Authors: Kaur Pavneet , Neelam Kumari , Sarao Preetinder S. , saini navneet , Dhir Yashika Walia , Khnna Renu , vikal Yogesh , Singh Kuldeep 
Published: June 2023

Abstract
Rice production is severely threatened by frequent outbreaks of Brown planthopper (BPH), Nilaparvata lugens (Stảl.) biotypes globally. On this account, host-plant resistance serves as an important strategy to reduce the damage caused by BPH. The wild species of rice Oryza nivara accession IRGC 93198 showed consistent resistance reaction against BPH biotype 4 for 5 consecutive years of screening under the greenhouse conditions. The mapping of the BPH resistance gene from Oryza nivara accession IRGC 93198 was conducted using BC2F2 and BC2F3 progenies. Out of 239 BC2F2 plants, 65 plants were resistant (1–3 score), and 174 plants (5, 7, and 9 score) were susceptible, thus fitting the segregation ratio of 3:1 (Susceptible: Resistant). The BC2F3 progenies segregated in 1:2:1 confirming that the resistance from O. nivara is governed by a single recessive gene. Bulked segregant analysis (BSA) identified genomic region on the short arm of chromosome 4 to be associated with BPH resistance. Molecular mapping performed on BC2F2 population identified QTL within the marker interval RM16285 and RM6314 explaining phenotypic variance of 27% at LOD 22.34. The linked marker RM6659 was found efficient in demarcating the susceptible from resistant lines when applied on the panel of rice cultivars, hence can be used for marker assisted selection in crop breeding. The previously identified BPH-resistant genes located on chromosome 4 were found susceptible to the BPH biotype 4 screening test. This specifies bph46 to be a novel gene that can be deployed as a valuable donor in BPH resistance breeding programs.
Comparison of Diagnostic Accuracy of SARC-F, SARC-CalF and Ishii’s Test for Diagnosis of Sarcopenia in Hospitalized Older Patients
Authors: yalcin ahmet , Gokce Busra , Turhan Gorkem , Atmis Volkan , Varlı Murat 
Published: June 2023

Abstract
Objectives
Sarcopenia, a common geriatric syndrome observed in older individuals, is known to be associated with negative health consequences. Several screening tools have been developed to identify sarcopenia in this population. This study aims to assess the diagnostic efficacy of three screening methods, SARC-F, SARC-F combined with calf circumference (SARC-CalF), and Ishii's test, for detecting sarcopenia in older individuals who are hospitalized.
Design:
This diagnostic accuracy study
Setting:
204 hospitalized older people.
Measurements:
Sarcopenia was assessed based on the diagnostic criteria established by the European Working Group on Sarcopenia in Older People 2. Muscle mass, muscle strength, and physical performance were evaluated using bioimpedance analysis, handgrip strength, and usual gait speed, respectively. Sensitivity and specificity analyses were conducted for the SARC-F, SARC-CalF, and Ishii's test to determine their effectiveness. Receiver operating characteristics curves were generated, and the area under the curve was calculated to compare the overall diagnostic accuracy of the SARC-F, SARC-CalF, and Ishii's test.
Results
The prevalence of sarcopenia is 41.4%. The SARC-F, SARC-CalF, and Ishii's tests demostrated sensitivities of 72%, 88.6%, and 93.5%, respectively, and specificities of 41%, 78.5%, and 30.3%.
Conclusion
SARC-CalF demonstrates the highest performance in terms of sensitivity and specificity compared to the other two tests, making it a valuable tool for detecting sarcopenia in hospital settings. On the other hand, Ishii's test exhibits high sensitivity but low specificity within this particular population