bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inguinal lymph node metastases from rectal adenocarcinoma: a systematic review
Authors: Wyatt James , Powell Simon G. , Ahmed Salma , Arthur James , Altaf Kiran , Ahmed Shakil , Javed Muhammad Ahsan 
Published: May 2023

Abstract
Purpose
Inguinal lymph nodes are a rare but recognised site of metastasis in rectal adenocarcinoma. No guideline or consensus exists for the management of such cases. This review aims to provide a contemporary and comprehensive analysis of the published literature to aid clinical decision-making.

Methods
Systematic searches were performed using the PubMed, Embase, MEDLINE and Scopus and Cochrane CENTRAL Library databases from inception till December 2022. All studies reporting on the presentation, prognosis or management of patients with inguinal lymph node metastases (ILNM) were included. Pooled proportion meta-analyses were completed when possible and descriptive synthesis was utilised for the remaining outcomes. The Joanna Briggs Institute tool for case series was used to assess the risk of bias.

Results
Nineteen studies were eligible for inclusion, encompassing 18 case series and one population-based study using national registry data. A total of 487 patients were included in the primary studies. The prevalence of ILNM in rectal cancer is 0.36%. ILNM are associated with very low rectal tumours with a mean distance from the anal verge of 1.1 cm (95% CI 0.92–1.27). Invasion of the dentate line was found in 76% of cases (95% CI 59–93). In patients with isolated inguinal lymph node metastases, modern chemoradiotherapy regimens in combination with surgical excision of inguinal nodes are associated with 5-year overall survival rates of 53–78%.

Conclusion
In specific subsets of patients with ILNM, curative-intent treatment regimens are feasible, with oncological outcomes akin to those demonstrated in locally advanced rectal cancers.
Mental Health and Wellbeing of Population with Migrant Background in Switzerland – a Scoping Review and Evidence Map of Quantitative Evidence
Authors: Gondek Dawid , Bernardi Laura 
Published: May 2023

AbstractWe aimed to map the evidence, based on population-based and migrant-specific datasets in Switzerland, on mental health and wellbeing of the population with migrant background. The research questions were: What is known from the existing quantitative evidence about the mental health of the population with migrant background living in Switzerland? What are the research gaps that can be addressed with existing secondary datasets in Switzerland? We used the scoping review approach to describe existing research. We searched Ovid MEDLINE and APA PsycInfo (2015 - September 2022). This resulted in a total of 1862 potentially relevant studies. In addition, we manually searched other sources, such as Google Scholar. We used a evidence map to visually summarise research characteristics and identify research gaps. In total, 46 studies were included in this review. Most studies used cross-sectional design (78.3%, n = 36) and theirs aims were descriptive (84.8%, n = 39). The studies tend to examine mental health or wellbeing of the population with migrant background in the context of social determinants (69.6%, n = 32). The most frequently studied social determinants were at the individual level (96.9%, n = 31). Out of 46 included studies, 32.6% (n = 15) included depression or anxiety, and 21.7% (n = 10) post-traumatic stress disorder and other traumas. Other outcomes were less commonly investigated. There was a lack of studies using longitudinal data investigating mental health of migrants that go beyond descriptive aims (i.e., explanatory and predictive), and have large nationally representative samples. Moreover, there is a need for research examining social determinants of mental health and wellbeing at the structural, family and community levels. We propose that existing nationally representative population-based surveys are used to a greater extent to study various aspects of migrants’ mental health and wellbeing.
Thermodynamic Evolution of a Metamorphic Protein: A Theoretical-Computational Study of Human Lymphotactin
Authors: Zanetti-Polzi Laura , Daidone Isabella , Iacobucci Claudio , Amadei Andrea 
Published: May 2023

AbstractMetamorphic, or fold-switching, proteins feature different folds that are physiologically relevant. The human chemokine XCL1 (or Lymphotactin) is a metamorphic protein that features two native states, an $$\alpha -\beta$$

α
-
β

and an all$$-\beta$$

-
β

fold, which have similar stability at physiological condition. Here, extended molecular dynamics (MD) simulations, principal component analysis of atomic fluctuations and thermodynamic modeling based on both the configurational volume and free energy landscape, are used to obtain a detailed characterization of the conformational thermodynamics of human Lymphotactin and of one of its ancestors (as was previously obtained by genetic reconstruction). Comparison of our computational results with the available experimental data show that the MD-based thermodynamics can explain the experimentally observed variation of the conformational equilibrium between the two proteins. In particular, our computational data provide an interpretation of the thermodynamic evolution in this protein, revealing the relevance of the configurational entropy and of the shape of the free energy landscape within the essential space (i.e., the space defined by the generalized internal coordinates providing the largest, typically non-Gaussian, structural fluctuations).
A network model for multiple selection questions in opinion surveys
Authors: Benati Stefano , Puerto Justo 
Published: May 2023

AbstractOpinion surveys can contain closed questions to which respondents can give multiple answers. We propose to model these data as networks in which vertices are the eligible items and arcs are the respondents. This representation opens up the possibility of using complex networks methodologies to retrieve information and most prominently, the possibility of using clustering/community detection techniques to reduce data complexity. We will take advantage of the implicit null hypothesis of the modularity function, namely, that items are chosen without any preferential pairing, to show how the hypothesis can be tested through the usual calculation of p-values. We illustrate the methodology with an application to Eurobarometer data. There, a question about national concerns can receive up to two selections. We will show that community clustering groups together concerns that can be interpreted in a consistent way and in general terms, such as Economy, or Security or Welfare issues. Moreover, we will show how different society groups are worried by different class of items.
Valorization of lignocellulosic biomass into sustainable materials for adsorption and photocatalytic applications in water and air remediation
Authors: Mergbi Meriem , Galloni Melissa Greta , Aboagye Dominic , Elimian Ehiaghe , Su Peidong , Ikram Belhadj M. , Nabgan Walid , Bedia Jorge , Amor Hedi Ben , Contreras Sandra , Medina Francisco , Djellabi‬‬‬‬‬‬‬‬ Ridha 
Published: May 2023

AbstractAn exponential rise in global pollution and industrialization has led to significant economic and environmental problems due to the insufficient application of green technology for the chemical industry and energy production. Nowadays, the scientific and environmental/industrial communities push to apply new sustainable ways and/or materials for energy/environmental applications through the so-called circular (bio)economy. One of today’s hottest topics is primarily valorizing available lignocellulosic biomass wastes into valuable materials for energy or environmentally related applications. This review aims to discuss, from both the chemistry and mechanistic points of view, the recent finding reported on the valorization of biomass wastes into valuable carbon materials. The sorption mechanisms using carbon materials prepared from biomass wastes by emphasizing the relationship between the synthesis route or/and surface modification and the retention performance were discussed towards the removal of organic and heavy metal pollutants from water or air (NOx, CO2, VOCs, SO2, and Hg0). Photocatalytic nanoparticle–coated biomass-based carbon materials have proved to be successful composites for water remediation. The review discusses and simplifies the most raised interfacial, photonic, and physical mechanisms that might take place on the surface of these composites under light irradiation. Finally, the review examines the economic benefits and circular bioeconomy and the challenges of transferring this technology to more comprehensive applications.
Algal sorbents and prospects for their application in the sustainable recovery of rare earth elements from E-waste
Authors: Pinto João , Colónia João , Abdolvaseei Azadeh , Vale Carlos , Henriques Bruno , Pereira Eduarda 
Published: May 2023

Abstract
Efficient and sustainable secondary sourcing of Rare-Earth Elements (REE) is essential to counter supply bottlenecks and the impacts associated with primary mining. Recycled electronic waste (E-waste) is considered a promising REE source and hydrometallurgical methods followed by chemical separation techniques (usually solvent extraction) have been successfully applied to these wastes with high REE yields. However, the generation of acidic and organic waste streams is considered unsustainable and has led to the search for “greener” approaches. Sorption-based technologies using biomass such as bacteria, fungi and algae have been developed to sustainably recover REE from e-waste. Algae sorbents in particular have experienced growing research interest in recent years. Despite its high potential, sorption efficiency is strongly influenced by sorbent-specific parameters such as biomass type and state (fresh/dried, pre-treatment, functionalization) as well as solution parameters such as pH, REE concentration, and matrix complexity (ionic strength and competing ions). This review highlights differences in experimental conditions among published algal-based REE sorption studies and their impact on sorption efficiency. Since research into algal sorbents for REE recovery from real wastes is still in its infancy, aspects such as the economic viability of a realistic application are still unexplored. However, it has been proposed to integrate REE recovery into an algal biorefinery concept to increase the economics of the process (by providing a range of additional products), but also in the prospect of achieving carbon neutrality (as large-scale algae cultivation can act as a CO2 sink).
Graphical abstract
Coronary and carotid artery dysfunction and KV7 overexpression in a mouse model of Hutchinson-Gilford progeria syndrome
Authors: Macías Álvaro , Nevado Rosa M. , González-Gómez Cristina , Gonzalo Pilar , Andrés-Manzano María Jesús , Dorado Beatriz , Benedicto Ignacio , Andrés Vicente 
Published: May 2023

AbstractHutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disease caused by expression of progerin, a lamin A variant that is also expressed at low levels in non-HGPS individuals. Although HGPS patients die predominantly from myocardial infarction and stroke, the mechanisms that provoke pathological alterations in the coronary and cerebral arteries in HGPS remain ill defined. Here, we assessed vascular function in the coronary arteries (CorAs) and carotid arteries (CarAs) of progerin-expressing LmnaG609G/G609G mice (G609G), both in resting conditions and after hypoxic stimulus. Wire myography, pharmacological screening, and gene expression studies demonstrated vascular atony and stenosis, as well as other functional alterations in progeroid CorAs and CarAs and aorta. These defects were associated with loss of vascular smooth muscle cells and overexpression of the KV7 family of voltage-dependent potassium channels. Compared with wild-type controls, G609G mice showed reduced median survival upon chronic isoproterenol exposure, a baseline state of chronic cardiac hypoxia characterized by overexpression of hypoxia-inducible factor 1α and 3α genes, and increased cardiac vascularization. Our results shed light on the mechanisms underlying progerin-induced coronary and carotid artery disease and identify KV7 channels as a candidate target for the treatment of HGPS.
Characterizing external visualization in mathematics education research: a scoping review
Authors: Schoenherr Johanna , Schukajlow Stanislaw 
Published: May 2023

AbstractExternal visualization (i.e., physically embodied visualization) is central to the teaching and learning of mathematics. As external visualization is an important part of mathematics at all levels of education, it is diverse, and research on external visualization has become a wide and complex field. The aim of this scoping review is to characterize external visualizations in recent mathematics education research in order to develop a common ground and guide future research. A qualitative content analysis of the full texts of 130 studies published between 2018 and 2022 applied a deductive-inductive coding procedure to assess four dimensions: visualization product or process, type of visualization, media, and purpose. The analysis revealed different types of external visualizations including visualizations with physical resemblance ranging from pictorial to abstract visualizations as well as three types of visualizations with structural resemblance: length, area, and relational visualizations. Future research should include measures of visualization products or processes to help explain the demands and affordances that different types of visualizations present to learners and teachers.
Experimental investigation of hydrogen-intensified synthetic natural gas production via biomass gasification: a technical comparison of different production pathways
Authors: Bartik Alexander , Benedikt Florian , Fuchs Josef , Hofbauer Hermann , Müller Stefan 
Published: May 2023

AbstractA sustainable and secure energy supply requires alternative concepts for energy generation. Utilizing biomass to produce synthetic natural gas (SNG) allows the synthesis of a currently widely used energy carrier on a renewable basis. The additional integration of hydrogen increases the carbon utilization of the biomass. This study experimentally investigates and compares the production of raw-SNG in three novel process chain configurations combining the advanced dual fluidized bed (DFB) gasification technology, gas cleaning units, and a fluidized bed methanation reactor. The three process chains comprise the direct methanation of DFB product gas, a hybrid route with hydrogen addition to the DFB product gas, and the methanation of a hydrogen-enriched product gas generated through DFB gasification with in situ CO2 removal (SER process). The direct methanation of the DFB product gas yielded a raw-SNG CH4 content of 40 vol.-%db at 360 °C and atmospheric pressure conditions. Through the integration of external hydrogen in a hybrid process, the carbon utilization of the biomass could be increased from 37% to around 70% at an unchanged cold gas efficiency of 58–59%. Via the SER process, a high raw-SNG CH4 content of 70 vol.-%db was achieved at an increased cold gas efficiency of 66% without the need for external hydrogen. Finally, a comparison points out the main advantages of the process configurations and provides a decision basis for novel SNG production pathways.
Survival following vertebral compression fractures in population over 65 years old
Authors: Gutiérrez-González Raquel , Royuela Ana , Zamarron Alvaro 
Published: May 2023

Abstract
Background
Lower mortality has been demonstrated when vertebral compression fractures (VCFs) are treated surgically (vertebral augmentation) vs. conservatively.

Aims
To analyze the overall survival in patients over 65 who suffer a VCF, to review the principal causes of death, and to detect which factors are associated with a greater risk of mortality.

Methods
Patients over 65 years old diagnosed with acute, non-pathologic thoracic or lumbar VCF, treated consecutively from January 2017 to December 2020, were retrospectively selected. Those patients with follow-ups under 2 years or who required arthrodesis were excluded. Overall survival was estimated by the Kaplan–Meier method. Differences in survival were tested through the log-rank test. Multivariable Cox regression was used to assess the association of covariates and time to death.

Results
A total of 492 cases were included. Overall mortality was 36.2%. Survival rate at 1-, 12-, 24-, 48-, and 60-month follow-up was 97.4%, 86.6%, 78.0%, 64.4%, and 59.4%, respectively. Infection was the leading cause of death. The independent factors associated with a higher mortality risk were age, male, oncologic history, non-traumatic mechanism, and comorbidity during hospitalization. No statistical difference was found when comparing the two survival curves by treatment (vertebral augmentation vs. conservative) over time.

Conclusion
Overall mortality rate was 36.2% after a median follow-up of 50.5 months (95% CI 48.2; 54.2). Age, male sex, history of oncological disease, non-traumatic mechanism of the fracture, and any comorbidity during hospitalization were identified as variables independently associated with a higher risk of mortality following a VCF in the elderly.
The Development of Disordered Eating in Male Adolescents: A Systematic Review of Prospective Longitudinal Studies
Authors: Byrne Shauna E. , Basten Christopher J. , McAloon John 
Published: May 2023

AbstractA lack of research exists about the development of disordered eating in adolescent males. A systematic review was undertaken with the primary aim of identifying psychosocial risk factors that are prospectively associated with the development of disordered eating attitudes and behavior in adolescent males. The review’s secondary aim was to appraise the appropriateness of the psychometric assessment measures used to identify those risk factors. Electronic databases Scopus (Elsevier), PsycINFO (EBSCO), PsycARTICLES, Medline (Ovid), Web of Science Core Collection and Pubmed (Thomson Reuters) were searched for prospective longitudinal research involving 11–19 year-old adolescents that was published between 2010 and 2022. Twenty-one publications met inclusion criteria and thirty-five factors including fourteen psychological factors, ten body appearance factors, four sociocultural factors, three familial and four peer factors were identified as prospectively associated with the development of disordered eating attitudes and behavior in male adolescents. The psychometric assessment measures used to identify those factors, together with the proportion of female respondents upon whose data the measures were based, were critically appraised. Accurate assessment is imperative in generating reliable and valid research and informing clinical practice. Existing female-centric psychometric assessments normed predominantly on female participants may not be appropriate for use with adolescent males.
A nuanced understanding of the doping of poly(3,4-ethylenedioxythiophene) with tosylate
Authors: Petsagkourakis Ioannis , Kim Donghyun , Modarresi Mohsen , Rudd Sam , Rudd Roya , Zozoulenko Igor , Evans Drew 
Published: May 2023

AbstractThe conducting polymer poly(3,4-ethylenedioxythiophene) (known as PEDOT) is routinely fabricated into doped thin films for investigation of its inherent properties as well as for a range of applications. Fabrication of PEDOT is often achieved via oxidative polymerisation, where the conducting polymer is polymerised and doped (oxidised) to yield a conductive polymer thin film. The oxidiser and the polymerisation temperature are two parameters that may influence the properties and performance of the resultant PEDOT thin film. In this study, the role of temperature for the chemical polymerisation of PEDOT using the oxidiser iron tosylate is investigated from a computational and experimental viewpoint. While computations of the doping energetics suggest increasing doping with increasing temperature, x-ray photoelectron spectroscopy of fabricated PEDOT thin films indicate doping is much more complicated. With the aid of computations of the spatial distribution functions for tosylate in PEDOT, experiments indicate that two different populations of tosylate anions exist in the PEDOT matrix. Their relative populations change as a function of the polymerisation temperature. Therefore, polymerisation temperature plays a critical role in tailoring the properties of PEDOT in pursuit of being fit-for-purpose for the desired application.
Cancellations of periodic orbits for non-singular Morse–Smale flows
Authors: LIMA D. V. S. , DE REZENDE K. A. , DA SILVEIRA M. R. 
Published: May 2023

AbstractIn this work, we explore the dynamical implications of a spectral sequence analysis of a filtered chain complex associated to a non-singular Morse–Smale (NMS) flow
$\varphi $
on a closed orientable
$3$
-manifold
$M^3$
with no heteroclinic trajectories connecting saddle periodic orbits. We introduce the novel concepts of cancellations and reductions of pairs of periodic orbits based on Franks’ morsification and Smale’s cancellation theorems. The main goal is to establish an algebraic-dynamical correspondence between the unfolding of this spectral sequence associated to
$\varphi $
and a family of flows obtained by cancelling and reducing pairs of periodic orbits of
$\varphi $
on
$M^3$
. This correspondence is achieved through a spectral sequence sweeping algorithm (SSSA), which determines the order in which these cancellations and reductions of periodic orbits occur, producing a family of NMS flows that reaches a core flow when the spectral sequence converges.
Remark on complements on surfaces
Authors: Liu Jihao 
Published: May 2023

Abstract
We give an explicit characterization on the singularities of exceptional pairs in any dimension. In particular, we show that any exceptional Fano surface is

$\frac {1}{42}$

-lc. As corollaries, we show that any

$\mathbb R$

-complementary surface X has an n-complement for some integer

$n\leq 192\cdot 84^{128\cdot 42^5}\approx 10^{10^{10.5}}$

, and Tian’s alpha invariant for any surface is

$\leq 3\sqrt {2}\cdot 84^{64\cdot 42^5}\approx 10^{10^{10.2}}$

. Although the latter two values are expected to be far from being optimal, they are the first explicit upper bounds of these two algebraic invariants for surfaces.
Leveraging Community Context, Data, and Resources to Inform Suicide Prevention Strategies
Authors: Barnard Leslie M. , Spark Talia L. , Leavitt Colton , Leary Jacob , Lehmkuhl Lee J. , Johnston Nicole , Wallace Erik A. 
Published: May 2023

AbstractColorado has consistently had one of the highest rates of suicide in the United States, and El Paso County has the highest number of suicide and firearm-related suicide deaths within the state. Community-based solutions like those of the Suicide Prevention Collaborative of El Paso County may be more effective in preventing suicide as they are specific to local issues, sensitive to local culture, and informed by local data, community members, and stakeholders.
Reasonable Accommodation and Disparate Impact: Clean Shave Policy Discrimination in Today’s Workplace
Authors: Jiang Yucheng (Renee) 
Published: May 2023

AbstractThis article examines Bey v. City of New York — a recent Second Circuit case where four Black firefights suffering from Pseudofolliculitis Barbae (a skin condition causing irritation when shaving which mostly affects Black men) challenged the New York City Fire Department’s Clean Shave Policy — with an intersectional approach utilizing legal theories of racial, disability, and religious discrimination.