bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Movement Habits Become Relevant in Novel Learning Situations
Authors: Barker Dean , Larsson Hakan , Nyberg Gunn 
Published: June 2023

Purpose: To (a) present a theoretical framework that describes how learners’ movement habits become relevant in the development of movement capability and (b) present data that illustrate how this process occurs in practice. Method: An investigation with preservice physical education teachers was conducted in two phases. The first phase involved examining participants’ movement habits, and the second phase involved examining the participants’ development of novel capabilities in the context of unicycling. Results: Empirical materials from two participants are presented as case studies. The cases demonstrate how different sets of movement habits interact with novel tasks, making the demand for creative action more or less likely. The cases also demonstrate how subjective and physical elements are interwoven. Finally, the cases provide insights into potentially productive habits for movement learning. Discussion/Conclusion: The paper is concluded with pedagogical implications, including a consideration of how crises might be managed in educational contexts.
‘Space to talk’: a Portuguese focus group study of parents’ experiences, needs and preferences in parenting support during prenatal and well-child care
Authors: Fareleira Filipa , Xavier Maria Raul , Tavares de Lima Filipa , Sampaio Reis Helena , Velte Julia , Martins Carlos 
Published: June 2023

ObjectiveTo explore the experiences, needs and preferences of a group of parents regarding the parenting support received during prenatal and well-child care in the Portuguese National Health Service.Design and settingWe undertook descriptive-interpretive qualitative research running multiple focus groups in Porto, Northern Portugal.Participants, data collection and analysisPurposive sampling was used between April and November 2018. Focus groups were conducted with 11 parents of a 0–3 years old with well-child visits done in primary care units. Thematic analysis was performed in a broadly inductive coding strategy and findings are reported in accordance with Consolidated Criteria for Reporting Qualitative Research guidelines.ResultsThree main themes were identified to describe parents’ experience when participating in their children’s healthcare: (1) logistics/delivery matter, including accessibility, organisation and provision of healthcare activities, unit setting and available equipment; (2) prenatal and well-child care: a relational place to communicate, with parents valuing a tripartite space for the baby, the family and the parent himself, where an available and caring health provider plays a major role and (3) parenting is challenging and looks for support, based on key points for providers to watch for and ask about, carefully explained and consensual among health providers.ConclusionThis study provides insight into parents’ needs and healthcare practices that affect the parenting experience. To meet parents’ preferences, sensitive health providers should guarantee a relational place to communicate and person-centredness, accounting for the whole family system to support healthy parenting collaboratively. Future studies are warranted to further strengthen the knowledge in the field of a population-based approach for parenting support.
Development and validation of a rurality index for healthcare research in Japan: a modified Delphi study
Authors: Kaneko Makoto , Ikeda Takaaki , Inoue Machiko , Sugiyama Kemmyo , Saito Manabu , Ohta Ryuichi , Cooray Upul , Vingilis Evelyn , Freeman Thomas R , Mathews Maria 
Published: June 2023

ObjectivesRural–urban healthcare disparities exist globally. Various countries have used a rurality index for evaluating the disparities. Although Japan has many remote islands and rural areas, no rurality index exists. This study aimed to develop and validate a Rurality Index for Japan (RIJ) for healthcare research.DesignWe employed a modified Delphi method to determine the factors of the RIJ and assessed the validity. The study developed an Expert Panel including healthcare professionals and a patient who had expertise in rural healthcare.SettingThe panel members were recruited from across Japan including remote islands, mountain areas and heavy snow areas. The panel recruited survey participants whom the panel considered to have expertise.ParticipantsThe initial survey recruited 100 people, including rural healthcare providers, local government staff and residents.Primary outcome measuresFactors to include in the RIJ were identified by the Expert Panel and survey participants. We also conducted an exploratory factor analysis on the selected factors to determine the factor structure. Convergent validity was examined by calculating the correlation between the index for physician distribution and the RIJ. Criterion-related validity was assessed by calculating the correlation with average life expectancy.ResultsThe response rate of the final survey round was 84.8%. From the Delphi surveys, four factors were selected for the RIJ: population density, direct distance to the nearest hospital, remote islands and whether weather influences access to the nearest hospital. We employed the factor loadings as the weight of each factor. The average RIJ of every zip code was 50.5. The correlation coefficient with the index for physician distribution was −0.45 (p<0.001), and the correlation coefficients with the life expectancies of men and women were −0.35 (p<0.001) and −0.12 (p<0.001), respectively.ConclusionThis study developed the RIJ using a modified Delphi method. The index showed good validity.
Cognitive and other neuropsychiatric symptoms in COVID-19: analysis of person-generated longitudinal health data from a community-based registry
Authors: Largent Joan , Xie Yiqiong , Knuth Kendall B , Toovey Stephen , Reynolds Matthew W , Brinkley Emma , Mack Christina D , Dreyer Nancy A 
Published: June 2023

ObjectiveTo describe cognitive symptoms in people not hospitalised at study enrolment for SARS-CoV-2 infection and associated demographics, medical history, other neuropsychiatric symptoms and SARS-CoV-2 vaccination.DesignLongitudinal observational study.SettingDirect-to-participant registry with community-based recruitment via email and social media including Google, Facebook and Reddit, targeting adult US residents. Demographics, medical history, COVID-19-like symptoms, tests and vaccinations were collected through enrolment and follow-up surveys.ParticipantsParticipants who reported positive COVID-19 test results between 15 December 2020 and 13 December 2021. Those with cognitive symptoms were compared with those not reporting such symptoms.Main outcome measureSelf-reported cognitive symptoms (defined as ‘feeling disoriented or having trouble thinking’ from listed options or related written-in symptoms)ResultsOf 3908 participants with a positive COVID-19 test result, 1014 (25.9%) reported cognitive symptoms at any time point during enrolment or follow-up, with approximately half reporting moderate/severe symptoms. Cognitive symptoms were associated with other neuropsychiatric symptoms, including dysgeusia, anosmia, trouble waking up, insomnia, headache, anxiety and depression. In multivariate analyses, female sex (OR, 95% CI): 1.7 (1.3 to 2.2), age (40–49 years (OR: 1.5 (1.2–1.9) compared with 18–29 years), history of autoimmune disease (OR: 1.5 (1.2–2.1)), lung disease (OR: 1.7 (1.3–2.2)) and depression (OR: 1.4 (1.1–1.7)) were associated with cognitive symptoms. Conversely, black race (OR: 0.6 (0.5–0.9)) and COVID-19 vaccination before infection (OR: 0.6 (0.4–0.7)) were associated with reduced occurrence of cognitive symptoms.ConclusionsIn this study, cognitive symptoms among COVID-19-positive participants were associated with female gender, age, autoimmune disorders, lung disease and depression. Vaccination and black race were associated with lower occurrence of cognitive symptoms. A constellation of neuropsychiatric and psychological symptoms occurred with cognitive symptoms. Our findings suggest COVID-19’s full health and economic burden may be underestimated.Trial registration numberNCT04368065.
Temporal structures that determine consistency and quality of care: a case study in hyperacute stroke services
Authors: Black Georgia B , Ramsay Angus I G , Simister Robert , Baim-Lance Abigail , Eng Jeannie , Melnychuk Mariya , Fulop Naomi J 
Published: June 2023

Background

Temporal structuring is determined by practices and social norms and affects the quality and timing of care
. In this case study of hyperacute stroke wards which provide initial stroke investigation, treatment and care, we explored temporal structuring patterns to explain how these may affect quality of care.

Methods
This paper presents a thematic analysis of qualitative interviews with hyperacute stroke staff (n=76), non-participant observations (n=41, ~102 hours) and documentary analysis of the relevant service standards guidance. We used an inductive coding process to generate thematic findings around the concept of temporal structuring, with graphically illustrated examples.

Results
Five temporal structures influence what-happens-when: (1) clinical priorities and quality assurance metrics motivate rapid activity for the initial life-prolonging assessments and interventions; (2) static features of ward organisation such as rotas and ward rounds impact consistency of care, determining timing and quality of care for patients; (3) some services experimented with staff rotas to try to meet peaks in demand, sometimes unsuccessfully; (4) implicit social norms or heuristics about perceived necessity affected staff motivation to make changes or improvements to consistency of care, particularly around weekend work; and (5) after-effects such as bottlenecks or backlogs affect quality of care, which are hard to measure effectively to drive service improvement.

Conclusions
Patients need temporally consistent high quality of care. Temporal consistency stems from the design of services, including staffing, targets and patient pathway design as well as cultural attitudes to working patterns. Improvements to consistency of care will be limited without changes to structures such as rotas and ward rounds, but also social norms around weekend work for certain professional groups.
Polyoxometalate Archetype-Boosted Stability and Charge Storage of 2D Graphene Nanosheets
Authors: Musa Ahammad , Islam Md. Mahinur , Bin Hasan Susan Md. Abu , Islam Md. Mominul 
Published: June 2023

In this study, the potential of impregnation of phosphotungstic acid (PTA), a polyoxometalate in enhancing specific capacitance (C
sp) and diminishing the well-known restacking phenomenon of graphene nanosheets was explored. Graphene nanosheets were prepared chemically from graphite powder through the formation of graphene oxide (GO) and then the subsequent reduction of GO to the reduced GO (rGO). Impregnation of PTA in rGO-PTA (rGP) composites was carried out by simply dispersing rGO and PTA derived from tungstic acid. Scanning electron microscopy, X-ray diffraction analysis, UV–vis reflectance spectroscopy, and Fourier-transform infrared spectroscopy were used to analyze the elemental composition, microstates, and morphology of the composites. The charge-storing capacity and stability of the prepared rGP composites casted on a graphite electrode were examined with cyclic voltammetric, chronopotentiometric, and electrochemical impedance techniques. The effect of ions on the charging capacity of the electrodes was verified using electrolytes with different ion sizes. About 100% enhancement of C
sp of rGO with 87% capacitance retention for 2000 charging-discharging cycles was achieved by impregnating rGP composites with only 1% PTA.
Mesenchymal-like Tumor Cells and Myofibroblastic Cancer-Associated Fibroblasts Are Associated with Progression and Immunotherapy Response of Clear Cell Renal Cell Carcinoma
Authors: Davidson Guillaume , Helleux Alexandra , Vano Yann A. , Lindner Véronique , Fattori Antonin , Cerciat Marie , Elaidi Reza T. , Verkarre Virginie , Sun Cheng-Ming , Chevreau Christine , Bennamoun Mostefa , Lang Hervé , Tricard Thibault , Fridman Wolf H. , Sautes-Fridman Catherine , Su Xiaoping , Plassard Damien , Keime Celine , Thibault-Carpentier Christelle , Barthelemy Philippe , Oudard Stéphane M. , Davidson Irwin , Malouf Gabriel G. 
Published: June 2023

Abstract

Immune checkpoint inhibitors (ICI) represent the cornerstone for the treatment of patients with metastatic clear cell renal cell carcinoma (ccRCC). Despite a favorable response for a subset of patients, others experience primary progressive disease, highlighting the need to precisely understand the plasticity of cancer cells and their cross-talk with the microenvironment to better predict therapeutic response and personalize treatment. Single-cell RNA sequencing of ccRCC at different disease stages and normal adjacent tissue (NAT) from patients identified 46 cell populations, including 5 tumor subpopulations, characterized by distinct transcriptional signatures representing an epithelial-to-mesenchymal transition gradient and a novel inflamed state. Deconvolution of the tumor and microenvironment signatures in public data sets and data from the BIONIKK clinical trial (NCT02960906) revealed a strong correlation between mesenchymal-like ccRCC cells and myofibroblastic cancer-associated fibroblasts (myCAF), which are both enriched in metastases and correlate with poor patient survival. Spatial transcriptomics and multiplex immune staining uncovered the spatial proximity of mesenchymal-like ccRCC cells and myCAFs at the tumor–NAT interface. Moreover, enrichment in myCAFs was associated with primary resistance to ICI therapy in the BIONIKK clinical trial. These data highlight the epithelial–mesenchymal plasticity of ccRCC cancer cells and their relationship with myCAFs, a critical component of the microenvironment associated with poor outcome and ICI resistance.

Significance:
Single-cell and spatial transcriptomics reveal the proximity of mesenchymal tumor cells to myofibroblastic cancer-associated fibroblasts and their association with disease outcome and immune checkpoint inhibitor response in clear cell renal cell carcinoma.
Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs With Potential to Prolong Cardiac Repolarization
Authors: Lee William , Ng Ben , Mangala Melissa M. , Perry Matthew D. , Subbiah Rajesh N. , Vandenberg Jamie I. , Hill Adam P. 
Published: June 2023

BACKGROUND:
Drug-induced or acquired long QT syndrome occurs as a result of the unintended disruption of cardiac repolarization due to drugs that block cardiac ion channels. These side effects have been responsible for the withdrawal of a range of drugs from market and are a common reason for termination of the development of new drugs in the preclinical stage. Existing approaches to risk prediction are expensive and overly sensitive meaning that recently there have been renewed efforts, largely driven by the comprehensive proarrhythmic assay initiative, to develop more accurate methods for allocation of proarrhythmic risk.

METHODS:
In this study, we aimed to quantify changes in the morphology of the repolarization phase of the cardiac action potential as an indicator of proarrhythmia, supposing that these shape changes might precede the emergence of ectopic depolarizations that trigger arrhythmia. To do this, we describe a new method of quantifying action potential morphology by measuring the radius of curvature of the repolarization phase both in simulated action potentials, as well as in action potentials measured from induced pluripotent stem cell-derived cardiomyocytes. Features derived from the curvature signal were used as inputs for logistic regressions to predict proarrhythmic risk.

RESULTS:
Optimal risk classifiers based on morphology were able to correctly classify risk to drugs in the comprehensive proarrhythmic assay initiative panels with very high accuracy (0.9375) and outperformed conventional metrics based on action potential duration at 90% repolarization, triangulation, and charge movement (qNet).

CONCLUSIONS:
Analysis of action potential morphology in response to proarrhythmic drugs improves prediction of torsadogenic risk. Furthermore, morphology metrics can be measured directly from the action potential, potentially eliminating the burden of undertaking complex screens of potency and drug-binding kinetics against multiple cardiac ion channels. As such, this method has the potential to improve and streamline regulatory assessment of proarrhythmia in preclinical drug development.
Evaluating and Modeling the Reliability of Continuous No-Rain Forecast from TIGGE Based on the First-Passage Problem and Fuzzy Mathematics
Authors: Cai Chenkai , Wang Jianqun , Li Zhijia , Shen Xinyi , Wen Jinhua , Wang Helong , Zhou Xinyan 
Published: June 2023

Abstract
As an important reference of reservoir regulation, more and more attention has been paid to the numeric precipitation forecast. Due to the uncertainty of meteorological prediction, reservoir regulation based on precipitation forecasts may lead to flood control risks. Therefore, the reliability of precipitation forecasts is crucial to the formulation of reservoir regulation strategy based on it. In this paper, a reliability assessment model for a continuous precipitation forecast is proposed based on the first-passage problem and fuzzy mathematics. The uncertainty of precipitation forecast is described by the generalized Bayesian model, and the fuzzy reliability of a continuous precipitation forecast can be obtained by the first-passage fuzzy probability model (FFPM). Due to the importance of a no-rain period in flood resource utilization, the no-rain forecasts from four different forecast centers in the Meishan basin are used as an example. The results show that the fuzzy mathematics is helpful in describing the uncertainty of the boundary for the no-rain set, and the fuzzy reliability of the no-rain forecast is affected by the selection of the range for the no-rain forecast, while the influence of the membership function is limited. Furthermore, due to the downward trend of fuzzy reliability as the lead time increases, there is a contradiction between excess water storage of the reservoir and the fuzzy reliability of the no-rain forecast. A longer continuous no-rain period means more excess water storage, but it also faces lower reliability. In actual reservoir regulation, the results of FFPM can be combined with more information to formulate better strategies for reservoir regulation.
Gender Differences in North American and International Otolaryngology Clinical Practice Guideline Authorship: A 17-Year Analysis
Authors: Mavedatnia Dorsa , Yi Grace , Wener Emily , Davidson Jacob , Chan Yvonne , Graham M. Elise 
Published: June 2023

Objective: To analyze gender differences in authorship of North American (Canadian and American) and international published otolaryngology—head and neck surgery (OHNS) clinical practice guidelines (CPG) over a 17-year period. Methods: Clinical practice guidelines published between 2005 and 2022 were identified through the Canadian Agency for Drugs and Technology in Health (CADTH) search strategy in MEDLINE and EMBASE. Studies were included if they were original studies, published in the English language, and encompassed Canadian, American, or international OHNS clinical practice guidelines. Results: A total of 145 guidelines were identified, encompassing 661 female authors (27.4%) and 1756 male authors (72.7%). Among OHNS authors, women and men accounted for 21.2% and 78.8% of authors, respectively. Women who were involved in guideline authorship were 31.0% less likely to be an otolaryngologist compared to men. There were no gender differences across first or senior author and by subspeciality. Female otolaryngologist representation was the greatest in rhinology (28.3%) and pediatrics (26.7%). American guidelines had the greatest proportion of female authors per guideline (34.1%) and the greatest number of unique female authors (33.2%). Conclusion: Despite the increasing representation of women in OHNS, gender gaps exist with regards to authorship within clinical practice guidelines. Greater gender diversity and transparency is required within guideline authorship to help achieve equitable gender representation and the development of balanced guidelines with a variety of viewpoints.
Mental health intervention research in Latin American correctional settings: A scoping review
Authors: Beigel Lukas , Forrester Andrew , Torales Julio , Aboaja Anne , Rivera Aroyo Guillermo , Roche Marcelo O’Higgins , Opitz-Welke Annette , Mundt Adrian P 
Published: June 2023

Background: The Latin American prison population has grown faster than anywhere else globally over the past two decades, reaching a total of 1.7 million people at any given time. However, research on mental health prevention and treatment interventions in Latin American prisons remains scarce. Aims: This study aimed to systematically review and synthesize research on prison mental health interventions conducted in the region. Methods: We used a two-stage scoping review design guided by the JBI Manual for Evidence Synthesis. Searches took place in December 2021 in nine databases using descriptors and synonyms. First, all prison mental health research in Latin America was retained. Secondly, using title and abstract screening, all research possibly related to interventions was retained for full text evaluation. Studies reporting interventions were assessed by country, language, institution, population, intervention type, intervention focus and outcomes. Results: N = 34 studies were included in this review. These were 13 case reports, seven expert consensus papers and 14 quantitative studies (four randomized controlled trials, nine cohort studies, one quasi-experimental study). Fourteen interventions were targeted at promoting prosocial behavior, seven studies each aimed to improve mental health and to treat substance use disorders. Six studies involved the treatment of sexual offending behavior, and 3 focused on reducing criminal recidivism. Psychoeducation (n = 12) and motivational interviewing (n = 5) were the most frequent intervention types studied. Promising data from trials showed that anger management, depression, substance use and reoffending could be successfully addressed through interventions. Conclusions: Implementation and effectiveness research of mental health interventions in Latin American prisons is scarce. Addressing mental health, substance use and prosocial behavior outcomes should be considered in future research. There is a particular dearth of controlled trials describing quantifiable outcomes.