bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human‐centred design thinking and public health education: A scoping review
Authors: Romero Vivian , Donaldson Holly 
Published: August 2023

AbstractIssue AddressedHuman‐centred design thinking (HCDT) is gaining traction to develop appropriate public health interventions. The HCDT process helps frame problems with intention and encourages experimentation through collaboration. Public health graduates need an expanded toolkit to solve both the complex known problems of today, and the adaptability to solve the unknown problems of tomorrow. But how is the health promotion workforce being prepared with this innovation capability? This scoping review aims to provide a pedagogical understanding of teaching HCDT in public health education.MethodsThe Arksey & O'Malley framework is used to structure this review. Peer‐reviewed articles written from 2000 to 2023 across eight databases were analysed. The data extracted included: author/year, setting, aim/purpose, participants, HCDT framework, HCDT methods, outcomes and challenges.ResultsNine relevant publications were included from a total of 208 records. The first reported use of HCDT in public health and health promotion teaching was in 2015. Teaching inspiration drew from established HCDT frameworks: d.school and IDEO which promote the iterative process of empathy/inspiration, ideation and testing/implementation.ConclusionsHCDT has been used for both designing public health curricula and for teaching students to apply it in their practice. First, HCDT methods can be used to problem‐solve teaching and learning issues such as creating inviting learning environments and designing an HCDT unit. Second, the teaching of HCDT can prepare and equip the public health workforce to solve problems requiring tailored solutions from an empathetic and iterative stance working as a team. The teaching and practice of HCDT exemplifies the process of social innovation in health promotion.So What?As an emerging field, future studies and applications should include clarifying and evaluating the HCDT stages used. More publications will enable a fuller understanding and potentially advocate the necessity of teaching and learning HCDT in public health and health promotion.
Receptors expressions on peripheral lymphocytes and CD4+CD183+ as a diagnostics biomarker for rheumatoid arthritis: A case–control study in Ghana
Authors: Sakyi Samuel Asamoah , Buckman Tonnies Abeku , Yeboah‐Mensah Kwame , Senu Ebenezer , Effah Alfred , Antwi‐Berko Daniel , Dey Dzifa , Antwi Maxwell H. , Yorke Joseph , Boateng Andy O. , Addei Akwasi M. , Tanko Muniru M. , Boateng Richard 
Published: August 2023

AbstractBackgroundT cell receptors play important roles in the development and progression of rheumatoid arthritis (RA). Their involvement has been reported in inflammatory autoimmune diseases. However, their role in predicting RA is still under exploration. This study evaluated the expression of CD183 (CXCR3) receptors on T‐cells and other relevant biomarkers for detecting RA and determine their relationship with disease activity.MethodsThis unmatched case–control study included 48 newly diagnosed RA patients and 30 apparent healthy controls from the orthopedic units of Komfo Anokye Teaching Hospital (KATH), Kumasi and Korle‐Bu Teaching Hospital (KBTH), Accra, Ghana. Sociodemographic data was obtained, and blood samples were also collected and processed for flow cytometric analysis. Statistical analyses were done using SPSS version 26.0 and R programming language. p < .05 was considered statistically significant.ResultsThis study found a significant difference in age group (p < .0001), marital status (p = .0210), occupation (p = .0140), educational level (p = .0210) and religion (p = .0100) between RA patients and healthy controls. Moreover, hemoglobin level (p = .0010), waist circumference (p < .0001) and hip circumference (p = .0040) were significantly different between RA patients and controls. RA patients had significantly lower levels of CD4+CD183+ compared with the control group (p < .001), and was positively correlated with DAS score (r = .0397, p = .789). In Receiver Operator Characteristics analysis, CD4+CD183+ could significantly detect RA with a high area under the curve (AUC = 0.687, p = .018). At a cut‐off of 0.082, CD4+CD183+ was the best receptor biomarker for detecting RA with a sensitivity of 90.0%, specificity of 25.9%, a positive predictive value of 69.2%, and a negative predictive value of 58.3%.ConclusionCD4+CD183+ best predict RA and is positively correlated with disease activity. CD4+CD183+ could serve as diagnostics and disease‐monitoring biomarker for RA; however, it demonstrates low specificity. Future studies should be directed on CD4+CD183+ and other biomarkers to augment their diagnostics performances and routine management in RA.
High systemic immune‐inflammation index is relevant to osteoporosis among middle‐aged and older people: A cross‐sectional study
Authors: Zhang Suli , Ni Wenyan 
Published: August 2023

AbstractBackgroundAs one of novel inflammatory indexes proposed in recent years, systemic immune‐inflammation index (SII) can comprehensively reflect the inflammatory and immune state of the body. This study aims to explore the relationship between SII and osteoporosis among middle‐aged and older people.Materials and MethodsOur study includes 20,497 individuals from National Health and Nutrition Examination Survey (NHANES) 2005–2008, and target study population are confined to people aged 45 years and above. SII is calculated as platelet count × neutrophil count/lymphocyte count. Multivariate logistic regression analysis is used to explore the link between SII and osteoporosis, and receiver operating characteristics curve is used to screen optimal cut‐off value of SII for indicating the occurrence of osteoporosis.ResultsA total of 435 people with osteoporosis are screened among 4625 middle‐aged and older people, and individuals in osteoporosis group have higher SII than those in nonosteoporosis group (p = .024). Logistic regression analysis indicates that with the enhancement of SII, prevalence of osteoporosis in each tertile category also increases (p < .001). This tendency is also not changed in univariate model (p < .001), as well as the adjustments for different parameters. Moreover, we also identify that SII of 530.09 is the optimal cut‐off value for indicating the occurrence of osteoporosis among middle‐aged and older people.ConclusionsThis present NHANES‐based study noticed that higher SII is positively linked to osteoporosis among middle‐aged and older people, and SII should not exceed 530.09 for them to obtain a potentially lower risk of osteoporosis.
Stretchable, skin‐conformable neuromorphic system for tactile sensory recognizing and encoding
Authors: Wu Mengge , Zhuang Qiuna , Yao Kuanming , Li Jian , Zhao Guangyao , Zhou Jingkun , Li Dengfeng , Shi Rui , Xu Guoqiang , Li Yingchun , Zheng Zijian , Yang Zhihui , Yu Junsheng , Yu Xinge 
Published: August 2023

AbstractExpanding wearable technologies to artificial tactile perception will be of significance for intelligent human–machine interface, as neuromorphic sensing devices are promising candidates due to their low energy consumption and highly effective operating properties. Skin‐compatible and conformable features are required for the purpose of realizing wearable artificial tactile perception. Here, we report an intrinsically stretchable, skin‐integrated neuromorphic system with triboelectric nanogenerators as tactile sensing and organic electrochemical transistors as information processing. The integrated system provides desired sensing, synaptic, and mechanical characteristics, such as sensitive response (~0.04 kPa−1) to low‐pressure, short‐ and long‐term synaptic plasticity, great switching endurance (>10 000 pulses), symmetric weight update, together with high stretchability of 100% strain. With neural encoding, demonstrations are capable of recognizing, extracting, and encoding features of tactile information. This work provides a feasible approach to wearable, skin‐conformable neuromorphic sensing system with great application prospects in intelligent robotics and replacement prosthetics.
Exploring the factors influencing Mobile‐based Ubiquitous System adoption in the Bangladesh RMG sector: A view through DOI and TOE
Authors: Ahad Taimur , Busch Peter 
Published: August 2023

AbstractRelatively little is known about micro‐ and macro‐level determinants of mobile phone ubiquitous system (MbUS) adoption by the manufacturing industry, such as is the case with the ready‐made garment (RMG) industry in Bangladesh. This research closes this gap, by presenting the adoption factors of MbUS in RMGs through applying the Rogers' Diffusion of Innovation theory and technology, organization, environment framework, to explore individual, technological, organizational, and environmental determinants of MbUS adoption. The study also reports on critical country level‐factors, organizational success factors and obstacles in MbUS adoption in RMGs. A qualitative method using interviews with the ready‐made garment (RMG) factory owners, managers, employees, and IT experts, suggests technological readiness, easily understandable MbUS technology, RMG capability, government intervention, and a supportive regulatory environment, were found to be macro‐level determinants of successful MbUS adoption. A survey was also conducted to explore the micro‐level customer‐centric factors, which found the relative advantages of MbUS, cost, the age of user's (p < 0.000), and influence on intention to use MbUS. This paper also identifies MbUS as a technical solution for time‐critical information in RMGs, the competitive environment of RMGs, empowerment opportunities and countrywide demands to improve the RMG situation, are important adoption factors of MbUS rarely identified in prior literature. The findings will be of value to RMGs, government, and MbUS developers, to accelerate development of MbUS in Bangladesh. Furthermore, the findings have implications for other developing countries by improving the capacity of RMGs, while realizing their own development goals through mobile technologies.
The relationship between mother and father racial‐ethnic socialization profiles and family cohesion and sociopolitical values among Asian American adolescents
Authors: Atkin Annabelle L. , Ahn Lydia HaRim , Yi Jacqueline 
Published: August 2023

AbstractIntroductionAlthough research on racial‐ethnic socialization with Asian American families examines academic and psychological outcomes, less is known about whether messages from mothers and fathers are related to their adolescent's Asian American sociopolitical values and family cohesion.MethodsCross‐sectional survey data were collected from 308 Asian American adolescents, ages 14−18, in the United States in 2021 (Mage = 16.83; standard deviation = 1.15).ResultsUsing latent profile analysis, we found that there were three socialization profiles for mothers (integration socialization, moderate separation socialization, and high separation socialization) and two for fathers (integration socialization and high separation socialization). The integration socialization reported more maintenance of heritage culture and becoming American messages, with the lowest reports of awareness of discrimination and avoidance of outgroups. The high separation profile had the highest amount of maintenance of heritage culture messages, awareness of discrimination, and avoidance of outgroups but lowest amount of becoming American messages. Looking at profiles for youths' perceptions of mothers, the moderate separation profile had slightly lower scores on maintenance of heritage culture messages, moderate scores on avoidance of outgroups, and higher reports of becoming American and awareness of discrimination compared to the high separation profile. Adolescents with mothers in the integration profile had the greatest mother‐child cohesion and highest level of sociopolitical values. With fathers, Asian American adolescents reported greater father−child cohesion in the integration profile, but there were no differences between socialization profiles and youth's Asian American sociopolitical values.ConclusionsFindings highlight the importance of parental messages on both identity outcomes (i.e., sociopolitical values) and family processes (i.e., family cohesion).
Vaginal wall thickness as potential biomarker of vaginal health. A proposal for standardized ultrasound measurement using three‐dimensional transvaginal ultrasound
Authors: Alcazar Juan Luis , Para Elisa , Tomaizhe Aida , Laza Maria Victoria , Guerriero Stefano 
Published: August 2023

AbstractVaginal wall thickness could be used as a biomarker of vaginal health. We propose a standardized method using three‐dimensional (3D) ultrasound for measuring vaginal wall thickness. Fill the vagina with gel. Insert the endovaginal transducer into the vagina up to the middle third. In the sagittal plane, visualizing the cervix and vaginal fornices, capture a 3D volume of the upper third of the vagina. Using tomographic ultrasound imaging function in the sagittal plane and the posterior vaginal fornix as the reference obtain at least three axial planes of the vagina, separated by 1 cm. Measure the vaginal wall thickness at a distance of 2 cm from the posterior vaginal fornix at 12, 3, 6, and 9 o'clock. The reproducibility of measurements was high. Measurements of vaginal wall thickness can be reliably performed.
A surrogate forelimb: Evolution, function and development of the avian cervical spine
Authors: Marek Ryan D. 
Published: August 2023

AbstractThe neck is a critical portion of the avian spine, one that works in tandem with the beak to act as a surrogate forelimb and allows birds to manipulate their surroundings despite the lack of a grasping capable hand. Birds display an incredible amount of diversity in neck morphology across multiple anatomical scales—from varying cervical counts down to intricate adaptations of individual vertebrae. Despite this morphofunctional disparity, little is known about the drivers of this enormous variation, nor how neck evolution has shaped avian macroevolution. To promote interest in this system, I review the development, function and evolution of the avian cervical spine. The musculoskeletal anatomy, basic kinematics and development of the avian neck are all documented, but focus primarily upon commercially available taxa. In addition, recent work has quantified the drivers of extant morphological variation across the avian neck, as well as patterns of integration between the neck and other skeletal elements. However, the evolutionary history of the avian cervical spine, and its contribution to the diversification and success of modern birds is currently unknown. Future work should aim to broaden our understanding of the cervical anatomy, development and kinematics to include a more diverse selection of extant birds, while also considering the macroevolutionary drivers and consequences of this important section of the avian spine.
Predictors of morbidity and in‐hospital mortality following procedure‐related cardiac tamponade
Authors: Deshpande Saurabh , Swatari Hiroyuki , Ahmed Raheel , Collins George , Khanji Mohammed Y. , Somers Virend K. , Chahal Anwar A. , Padmanabhan Deepak 
Published: August 2023

AbstractBackgroundCardiac tamponade (CT) can be a complication following invasive cardiac procedures. We assessed CT following common cardiac electrophysiology (EP) procedures to facilitate risk prediction of associated morbidity and in‐hospital mortality.MethodsPatients who underwent various EP procedures in the cardiac catheterization lab (ablations and device implantations) were identified using the International Classification of Diseases, Ninth and Tenth Edition, Clinical Modification (ICD‐9‐CM and ICD‐10‐CM, respectively) from the Nationwide Inpatient Sample (NIS) database. Patient demographics, presence of comorbidities, CT‐related events, and in‐hospital death were also abstracted from the NIS database.ResultsThe frequency of CT‐related events in patients with EP intervention from 2010 to 2017 ranged from 3.4% to 7.0%. In‐hospital mortality related to CT‐related events was found to be 2.2%. Increasing age was the only predictor of higher mortality in atrial fibrillation (AF) ablation and cardiac resynchronization therapy (CRT) groups (OR [95% CI]: AF ablation = 11.15 [1.70–73.34], p = .01; CRT = 1.41 [1.05–1.90], p = .02).ConclusionsIn the real‐world setting, CT‐related events in EP procedures were found to be 3.4%–7.0% with in‐hospital mortality of 2.2%. Older patients undergoing AF ablation were found to have higher mortality.
Reversing seasonality of Southern Hemisphere Annular Mode trend in the 21st century
Authors: Zheng Fei , Liu Xiaoning , Wang Hao , Li Yuxun , Wang Rui , Yao Shuailei , Dong Wenjie 
Published: August 2023

AbstractThe Southern Hemisphere Annular Mode (SAM) is the dominant mode of atmospheric circulation in the Southern Hemisphere extratropical region. In the late 20th century, the SAM underwent a remarkable positive trend, with the strongest trend occurring in austral summer because of Antarctic ozone depletion. In this study, we quantitatively explore changes in the seasonality of the SAM trend under the background of ozone recovery. As expected, accompanied by ozone recovery since 2001, the summer SAM trend has decreased, thus reducing the seasonal difference in the SAM trend between summer and winter. However, what was not expected and found in this study is that the winter SAM has meanwhile shown an increasing positive trend in the early 21st century, which further reverses the seasonality of the SAM trend, leading to a stronger trend in winter rather than summer, which is different from the seasonality in the late 20th century. The reason underlying the winter SAM changes is explored from the perspective of natural variability. Winter SAM exhibits clear multidecadal variability, and the recent increasing trend is a part of multidecadal oscillation. The multidecadal variability of winter SAM may partly originate from the Atlantic Multidecadal Oscillation. The seasonality of linear trend in extratropical surface climate also exhibits reversing characteristics since 2001. In the early 21st century, the acceleration of westerlies and the strengthening of Amundsen Sea Low are stronger in winter, reversing the previous seasonality in the late 20th century, in which the acceleration of westerlies and the strengthening of Amundsen Sea Low is stronger in summer.
Down the drain: The dynamic interplay of governance adjustments addressing setbacks in large public–private projects
Authors: Fang F. , van der Valk W. , Vos B. , Akkermans H. A. 
Published: August 2023

AbstractLarge government projects involving public–private collaborations inherently suffer from setbacks such as delays, cost overruns, or failure to meet contracted performance. Such setbacks may effectively be addressed through adjustments to contractual and relational governance; yet to date, the dynamics of governance adjustments and their interplay in addressing setbacks is not well understood. This research presents a dynamic theory of how parties can effectively address project setbacks through adjustments to contractual and relational governance. The dynamic theory was generated using longitudinal case data from two large public–private projects in the Netherlands that faced comparable project setbacks but deployed opposing governance adjustments, leading to drastically different project outcomes (i.e., collapse vs. recovery). This theory was then elaborated through two more cases and evidence from the literature. A system dynamics simulation model was then built that reproduces the different governance adjustments and outcomes observed in the four projects and serves to extend theory building. The refined theory not only shows under what conditions adjustments to contractual or relational governance are most effective, but also that governance adjustment interplay may trigger unintended side effects. As such, the theory explains why the careful balancing of governance adjustments is critical to project outcomes.
Effects of gait modifications on tissue‐level knee mechanics in individuals with medial tibiofemoral osteoarthritis: A proof‐of‐concept study towards personalized interventions
Authors: Esrafilian Amir , Halonen Kimmo S. , Dzialo Christine. M. , Mannisi Marco , Mononen Mika E. , Tanska Petri , Woodburn Jim , Korhonen Rami K. , Andersen Michael S. 
Published: August 2023

AbstractGait modification is a common nonsurgical approach to alter the mediolateral distribution of knee contact forces, intending to decelerate or postpone the progression of mechanically induced knee osteoarthritis (KOA). Nevertheless, the success rate of these approaches is controversial, with no studies conducted to assess alterations in tissue‐level knee mechanics governing cartilage degradation response in KOA patients undertaking gait modifications. Thus, here we investigated the effect of different conventional gait conditions and modifications on tissue‐level knee mechanics previously suggested as indicators of collagen network damage, cell death, and loss of proteoglycans in knee cartilage. Five participants with medial KOA were recruited and musculoskeletal finite element analyses were conducted to estimate subject‐specific tissue mechanics of knee cartilages during two gait conditions (i.e., barefoot and shod) and six gait modifications (i.e., 0°, 5°, and 10° lateral wedge insoles, toe‐in, toe‐out, and wide stance). Based on our results, the optimal gait modification varied across the participants. Overall, toe‐in, toe‐out, and wide stance showed the greatest reduction in tissue mechanics within medial tibial and femoral cartilages. Gait modifications could effectually alter maximum principal stress (~20 ± 7%) and shear strain (~9 ± 4%) within the medial tibial cartilage. Nevertheless, lateral wedge insoles did not reduce joint‐ and tissue‐level mechanics considerably. Significance: This proof‐of‐concept study emphasizes the importance of the personalized design of gait modifications to account for biomechanical risk factors associated with cartilage degradation.
Software‐based screening for efficient sgRNAs in Lactococcus lactis
Authors: Wang Hui , Ai Lianzhong , Xia Yongjun , Wang Guangqiang , Xiong Zhiqiang , Song Xin 
Published: August 2023

AbstractBACKGROUNDThe two essential editing elements in the clustered regularly interspaced short palindromic repeats (CRISPR) editing system are promoter and single‐guide RNA (sgRNA), the latter of which determines whether Cas protein can precisely target a specific location to edit the targeted gene. Therefore, the selection of sgRNA is crucial to the efficiency of the CRISPR editing system. Various online prediction tools for sgRNA are currently available. These tools can predict all possible sgRNAs of the targeted gene and rank sgRNAs according to certain scoring criteria according to the demands of the user.RESULTSWe designed sgRNAs for Lactococcus lactis NZ9000 LLNZ_RS02020 (ldh) and LLNZ_RS10925 (upp) individually using online prediction software – CRISPOR – and successfully constructed a series of knockout strains to allow comparison of the knockout efficiency of each sgRNA and analyze the differences between software predictions and actual experimental results.CONCLUSIONOur experimental results showed that the actual editing efficiency of the screened sgRNAs did not match the predicted results – a phenomenon that suggests that established findings from eukaryotic studies are not universally applicable to prokaryotes. Software prediction can still be used as a tool for the initial screening of sgRNAs before further selection of suitable sgRNAs through experimental experience. © 2023 Society of Chemical Industry.