bluuebunny/crossref_metadata_2025_split huggingface dataset:
An unusual presentation of Goodpasture syndrome
Authors: George Jisa , Rajarathinam Buddhan , Kulasekaran Rajkumar , Kurhekar Pranjali 
Published: March 2023

ABSTRACT
Goodpasture disease is an anti–glomerular basement membrane (anti-GBM) disease that manifests as progressive glomerulopathy and alveolar hemorrhage. Our case was a 68-year-old female who presented with decompensated liver disease (DCLD) with no prior history suggestive of liver disease. She had dyspnea, bilateral pitting edema, icterus with normal renal parameters, and elevated liver enzymes. Ultrasonogram revealed shrunken liver, ascites, and portal hypertension with normal renal cortex echogenicity. Over the next three days, she developed progressive oliguria, hematuria, and breathlessness, with arterial blood gas showing hypoxia with acidosis and hyperkalemia. Bronchoscopic alveolar lavage was suggestive of hemorrhagic fluid. The patient succumbed to the disease in 24 hours. Anti-GBM antibodies came positive by immunofluorescence assay which confirmed the diagnosis of Goodpasture syndrome. Unusual presentation of DCLD in our case resulted in a delay in diagnosis that could have been crucial in altering the outcome.
The efficacy of paravertebral block evaluated by pain-related biomarkers and reactive oxygen species (ROS) following surgery for breast cancer
Authors: Mitragotri Milon V. , Sheikh Safiya I. , Alur Jagadish , Kurugodiyavar Mahesh D. , Vanti Gulamnabi L. , Sarasamma Athira G. 
Published: March 2023

ABSTRACT

Background and Aims:
Paravertebral block has been found to be a recommended method of analgesia for breast surgeries. We aimed to assess the efficacy of paravertebral block compared to morphine by means of the visual analogue scale (VAS), pain-related biomarkers, and reactive oxygen species (ROS) in adult patients undergoing breast cancer surgeries under general anesthesia.

Methodology:
Forty patients undergoing breast surgery with or without lymph outcome were randomly divided into two groups. Group M received general anesthesia with intraoperative injection morphine (0.1 mg/kg) and group P received general anesthesia with paravertebral block with 0.25% bupivacaine (0.3 ml/kg). The primary objective was to compare the postoperative pain using VAS at baseline, 2 hours, 24 hours, and 48 hours. Secondary objectives were to compare the levels of pain-related biomarkers and ROS in both the groups at baseline, 24 hours, and 48 hours and to study the correlation between the VAS and level of pain-related biomarkers and ROS.

Results:
There was no significant difference in the postoperative VAS scores in both the groups (P = 0.252, 0.548, 0.488 at baseline, 24 hours, and 48 hours, respectively) and no significant difference in the mean biomarkers in both the groups. The mean VAS negatively correlated with biomarker levels at 24 hours and 48 hours, but the change in VAS after 24 hours and 48 hours did not significantly correlate with the change in the biomarkers.

Conclusion:
Paravertebral block is equally efficacious to intraoperative morphine for breast surgeries for postoperative analgesia. The biomarker levels were not significantly different when patients received paravertebral block or morphine.
Anaphylaxis spares no drug
Authors: Makker Robina , Mishra Priyanka , Ahuja Kanishak 
Published: March 2023

ABSTRACT
Peri-anesthetic anaphylaxis is a rare but grave problem. After receiving informed consent for publication, we discuss the case of a female patient posted for laparoscopic cholecystectomy who developed an anaphylactic reaction to intravenous diclofenac, mimicking post-laparoscopy respiratory complication in the perioperative period. A 45-year-old, American Society of Anesthesiologists physical status (ASA-PS) I, female patient was posted for laparoscopic cholecystectomy under general anesthesia (GA). The procedure took 60 minutes and concluded uneventfully. In the post-anesthesia care unit, the patient complained of respiratory difficulty. Even after the supplemental oxygen and in absence of any significant finding on respiratory examination, the patient soon developed severe cardiorespiratory collapse. On evaluation, administration of intravenous diclofenac a few minutes before the event was suspected as the trigger for this anaphylactic response. The patient responded to the injection of adrenaline, and her post-surgical progress over the next two days was uneventful. The retrospective tests done for confirming diclofenac hypersensitivity were found to be positive. No drug, however safe, should be given blindly without proper observation and monitoring. The course of development of anaphylaxis can range from a few seconds to minutes and hence, the earliest recognition and prompt action can be the only deciding factor between life and death for such patients.
Anesthetic concerns of achondroplastic patients with hip movement restriction scheduled for retrograde intrarenal surgery
Authors: Bandyopadhyay Soumily , Kumar Amit , Ayub Arshad 
Published: March 2023

ABSTRACT
Achondroplasia is an autosomal dominant inherited disorder that results in premature ossification of the epiphyseal growth plates and restriction of proximal long bone movement. Herein, we report the anesthetic management of such a patient undergoing stone retrieval in the lithotomy position. He had a restricted ability to flex and abduct the hip joint and lumbar hyperlordosis. These were anticipated to be a concern for the lithotomy position and prone to positional injuries. Hence, the decision was made to position the patient before induction of anesthesia in the presence of surgeons to ensure the optimal exposure needed for the procedure while avoiding any hyperflexion or abduction of the hip and knee joints. The position tolerated by the patient when awake and unsedated should be followed intraoperatively. Achondroplasia is also associated with difficult airway features, obesity, sleep apnea, and multisystem involvement. Careful preoperative evaluation and intraoperative vigilance are needed to manage these patients undergoing surgery.
Central pontine myelinolysis after liver transplant
Authors: Biagio Murta e Di Flora Francisco , Machado Oliveira Maurício Vitor , Henrique Torres Menezes Pedro , Delgado Marina Ayres 
Published: March 2023

ABSTRACT
Based on brain magnetic resonance imaging results, the second and third most frequent causes of central pontine myelinolysis (CPM) were liver transplant (LT) and cirrhosis, which together accounted for 13.7% and 12.5% of all diagnoses of CPM. Medical diseases including cirrhosis, LT, malnutrition, and alcoholism are well-known conditions associated with CPM in addition to hyponatremia. The prognosis is poor and depends on early diagnosis and treatment to achieve better outcomes. This is a case report of CPM occurring after a deceased donor LT in a patient presenting many risk factors such as chronic hyponatremia, previous episodes of encephalopathy, and tacrolimus immunosuppression. We briefly discuss the pathophysiology, risk factors, diagnosis, and treatment, highlighting the role and challenges of the anesthesiologist in managing this kind of patient and preventing the syndrome in the context of major surgery.
Space-Time Methods for Time-Dependent Partial Differential Equations
Authors: Larsson Stig , Nochetto Ricardo H. , Sauter Stefan A. , Wieners Christian 
Published: March 2023

Modern discretization and solution methods for time-dependent PDEs consider the full problem in space and time simultaneously and aim to overcome limitations of classical approaches by first discretizing in space and then solving the resulting ODE, or first discretizing in time and then solving the PDE in space.
The development of space-time methods for hyperbolic and parabolic differential equation is an emerging and rapidly growing field in numerical analysis and scientific computing. At the first Workshop on this topic in 2017 a large variety of interesting and challenging concepts, methods, and research directions have been presented; now we exchange the new developments.
The focus is on the optimal convergence of discretizations and on efficient error control for space-time methods for hyperbolic and parabolic problems, and on solution methods with optimal complexity. This is complemented by applications in the field of time-dependent stochastic PDEs, non-local material laws in space and time, optimization with time-dependent PDE constraints, and multiscale methods for time-dependent PDEs.
The Status of Antioxidants and Oxidative Damage in Patients with COVID-19
Authors: BİNİCİ İrfan , ALP Hamit Hakan , HUYUT Zübeyir , GÜRBÜZ Esra , GÜNBATAR Hülya , AKMEŞE Şükrü , KARAHOCAGİL Mustafa Kasım 
Published: March 2023

Objectives: COVID-19 is an important viral disease that affects human health significantly. It has recently become widespread worldwide. The oxidant/antioxidant balance has an important effect on viral infections. This study investigated superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione (GSH), total thiol (TT), native thiol (NT), disulphide (DS), oxidative DNA damage, and malondialdehyde (MDA) levels in COVID-19 patients.
Material and methods: 35 patients were diagnosed with COVID-19 by reverse transcriptase-polymerase chain reaction (RT-PCR), and 35 healthy volunteers at Dursun Odabaş Medical Center were included in the study. Levels of GSH, GPx, SOD, NT, TT and DS were measured by enzyme-linked immunosorbent assay (ELISA) in the serum samples. MDA and 8-hydroxy-2-deoxyguanosine/106deoxyguanosine (8-OHdG/106dG) were measured by high-pressure liquid chromatography (HPLC) in the serum samples.
Results: SOD, GSH-PX, GSH, NT and TT levels were lower in the COVID-19 patient group compared to the healthy control group, while the levels of DS and 8-OHdG/106dG were significantly higher (p=0.001). In addition, there were a negative correlation between 8-OHdG/106dG and GSH, NT and TT, while there was a positive correlation with DS.
Conclusion: This study revealed that SOD, GPX, MDA, 8-OHdG, and DS increased and GSH, NT, and TT decreased in COVID-19 patients. These results revealed that COVID-19 patients have reduced levels of antioxidant proteins and increased oxidative stress markers.
Pengaruh Kompensasi dan Motivasi Kerja terhadap Kinerja Karyawan dengan Kepuasan Kerja sebagai Variabel Mediasi pada Organisasi Oppio Coffe Yogyakarta
Authors: Angody Ilvan Arjun , Prayekti Prayekti 
Published: March 2023

The purpose of this study is to describe (1) the effect of compensation on employee performance. (2) The effect of work motivation on employee performance. (3) the effect of job satisfaction on employee performance. (4) job satisfaction mediates the effect of motivation on employee performance. (5) job satisfaction mediates the effect of compensation on employee performance. This research is a type of quantitative research, with a population of all employees of Oppio Coffee Yogyakarta. The sampling technique in this study is a non-probability sampling technique where the technique used is saturated sampling (census). The number of samples in this study were 53 employees of Oppio Coffee Yogyakarta. Data collection techniques in this study using a questionnaire. The data analysis methods used in this research are validity test, reliability test, descriptive test, classical assumption test, multiple linear regression and Sobel test. Data analysis was conducted to identify the independent variables that affect the dependent variable.The results showed that (1) compensation had no positive and significant effect on employee performance. (2) Compensation has no positive and significant effect on employee job satisfaction. (3) Job satisfaction has a positive and significant effect on employee performance. (4) job satisfaction as a mediating variable of the effect of compensation on employee performance has a positive and significant effect. (5) Job satisfaction as a mediating variable the effect of work motivation on employee performance has a positive and significant effect.
Keywords : compensation, work motivation, employee performance, job satisfaction.
Analisa Kesehatan Fiskal di Provinsi Riau Periode 2019 – 2021
Authors: Mukaddas Hamsina , Saefudin Mohamad , Puspitasari Mila , Digdowiseiso Kumba 
Published: March 2023

The condition of regional fiscal health is a condition for implementing regional autonomy and fiscal decentralization. This study took samples of districts/cities in Riau Province in the period 2019 - 2021 to be analyzed using the Fiscal Health Index. The results of the analysis will be able to describe the condition of the fiscal health of each Regency/City in the Riau Province area before and during the Covid-19 pandemic. The research method used is a quantitative descriptive study and determines all districts/cities as the unit of analysis. The measurement model used refers to the Regulation of the Minister of Home Affairs of the Republic of Indonesia Number 19 of 2020 concerning Measurement of the Regional Financial Management Index, but only focuses on 3 (three) indicators from the dimensions of regional financial conditions. The three indicators are financial independence, financial flexibility, and service solvency. The results of this study can be concluded that of the 12 districts/cities in Riau Province are included in the low category, both in financial independence, financial flexibility and service solvency. This condition may affect their ability to implement decentralization and regional autonomy. Of the 12 Regencies/Cities in Riau Province that have the highest Fiscal Health Index in a row in 2019-2021 are Bengkalis and Kepaluauan Meranti Regencies, while those with the lowest Fiscal Health Index are Indragiri Hulu and Indragiri Hilir Regencies. This comparison is only in the scope of Regencies/Cities in Riau Province.
Keywords: Regional Fiscal Health, Fiscal Decentralization, Financial Independence, Financial Flexibility, Service Solvability
Upaya Pencegahan Stunting dan Potensi Tumbuh Kembang Anak
Authors: Mukhsin Abd. Mukhsin , Nasution, Dini Rahmawati , Farha Mazidatul , Mustika Mustika , Nahda Zuhra 
Published: March 2023

Stunting is a developmental disorder experienced by children due to poor nutrition, repeated infections, and inadequate psychosocial stimulation. Stunting is a condition in which children experience growth disorders as a result of insufficient nutritional intake for a relatively long time, causing the child's height to not match his age. Some of the factors that cause stunting are the practice of giving colostrum and exclusive breastfeeding, children's consumption patterns, and infectious diseases, access and availability of food ingredients as well as environmental sanitation and health. Stunting that has occurred if it is not balanced with catch-up growth results in decreased growth, the problem of stunting is a public health problem associated with an increased risk of illness, death and inhibition of both motor and mental growth.
Keywords: Children, Prevention, Stunting
Upaya Peningkatan Minat Baca Murid SD 112318 Sipare-pare Tengah
Authors: Batubara Indah Wulan Sari , Hasibuan Elda Anzely , Sipahutar Mispa Herlina Wati , Sipahutar Mispa Herlina Wati , Tanjung Intan Sari , Syahputra Abdi , Munandar Arif , Panjaitan Nurul Hayati , Damayanti Nefi 
Published: March 2023

Efforts to increase children's interest in reading are a shared responsibility, between librarians, teachers, parents, and the community are directly responsible for developing interest in reading. To develop interest in reading, children need to be given stimuli that encourage interest in reading students themselves. Efforts to encourage students to read as many books as possible are not effective. Forcing children to buy books is also unethical. One of the activities carried out to develop and increase interest in reading for each student is the provision of subsidized textbooks. This book is a reference for students and teachers in schools where textbooks and the learning process always try to complement the reading. Books that stimulate children's interest in reading. Increasing interest and interest in reading, especially among students, requires effective library management. The purpose of this research is to increase students' reading interest which is still very low. The location of this survey is SD Negeri 112318, Merbau Regency, Sipare-Pare Tengah. and has a learning theme for grades 3 and 5.
Keywords: Reading Interest, Librarian, Library
Impact of Climate Change on Intermodal Transportation
Authors: David Merly 
Published: March 2023

Purpose: The purpose of the study is to examine the impacts of climate change on intermodal transport.
Methodology: This study adopted a desktop methodology. This study used secondary data from which include review of existing literature from already published studies and reports that was easily accessed through online journals and libraries.
Findings: The impact of climate change on intermodal transport is associated with heavy rains, carbon dioxide emissions and greenhouse gases. The study also found that climate change has made the transport sector to develop strategies to mitigate the effect of climate change.
Unique Contribution to Theory, Practice and Policy: The study used the agro-economic models and ricardian model for climate change assessment. The study recommended that additional maintenance and rehabilitation costs may be required to compensate for additional distresses related to climate change. Therefore there is need for heavy investment of emergency funds for repair and maintenance of the way, this includes ports and seas.
Temperature Change in the Contiguous 48 States Between 1901 and 2020
Authors: Cappelletti Lucas W. , Lash Benjamin L. , Levine Noah E. , Sommers Paul Martin 
Published: March 2023

Climate change has become a global emergency. Many people have studied the rise in temperatures over the last few decades. But few have studied how monthly average temperatures at the state level in the United States have changed for more than a century.
The authors divide the 120-year period January 1901 to December 2020 into two 60-year periods and then compare the monthly average temperature in each period for each of the 48 contiguous U.S. states. When these data are divided into seasons, the largest changes are observed for winter (December, January, ad February) and summer (June, July, and August) months, especially among states that have coastal access to the Pacific Ocean or the Atlantic Ocean in the northeast.
Apart from presenting a series of two-sample t-tests for each of the 48 states for all seasons combined and one for each of the four seasons, the authors also present color-coded maps summarizing the statistical results for the winter and summer seasons. The maps use the p-value of each two-sample t-test to show which states in each season between the two 60-year periods are getting cooler (green, light blue, dark blue) and which states are getting warmer (yellow, orange, red).
Evaluating the effects of implementing a hospital-acquired pressure injury risk assessment hand-off tool
Authors: Baldwin Stena , Junious DeMonica 
Published: March 2023

More than 2.5 million patients suffer from pressure ulcer injuries each year, estimating that 60,000 die from complications (Joint Commission Center for Transforming Healthcare, 2021). Hospital acquired pressure injuries (HAPI) present as skin and muscle damage, slowed healing, and increased pain and infections that result from delayed wound care and treatments to fragile areas. Reports from Rondinelli et al. (2018) showed that implementing a HAPI risk assessment hand-off tool worked to reduce such events.
In 2021, a coastal community hospital located in Southeast Texas recorded 5% HAPI events, which resulted in the creation of a student developed HAPI risk assessment hand-off tool. The aim of this quality improvement (QI) project was to decrease HAPI events in the Cardiothoracic IMU to 0% by February 2022. Kurt Lewin's Change Theory was used to guide project interventions.
After receiving project approval, four changes were implemented. A unit champion, responsible for monitoring the accuracy of Braden Score documentation was designated. Nurses implemented interaction-based patient repositioning every 2 hours and participated in monthly HAPI prevention and education meetings. Lastly, nurses completed the hand-off tool to verify staff compliance. Chart audits and a student developed questionnaire was used to determine the usefulness of the HAPI risk assessment hand-off tool. After one month of chart audits, and use of the hand off tool, the HAPI occurrence rate decreased to 3%. This project concluded that the student developed HAPI risk assessment hand-off tool had no significant effect on the reduction of HAPI occurrences within the cardiothoracic IMU.
De eeuw van de grote reparaties
Authors: Van Tussenbroek Gabri 
Published: March 2023

Dit artikel gaat in op een aantal zeer ingrijpende reparaties van Amsterdamse gebouwen in de zeventiende en achttiende eeuw. Het gaat daarbij om twee soorten reparaties: herstel van fundamenten en reparatie van steun- en kapconstructies. Problemen met fundamenten konden worden veroorzaakt door een fluctuerende grondwaterstand, een te hoog gelegd fundament of ondeugdelijkheden in de constructie, al dan niet in combinatie met onregelmatigheden in de natuurlijke drassige ondergrond. Behalve huizen, waarvan de fundamenten al veel eerder werden verstevigd, kwamen vanaf de vroege zeventiende eeuw reparaties van torens voor. Daarbij werd doorgaans een extra fundering geslagen waaraan de bestaande structuur werd verankerd. Bekende voorbeelden zijn de Stadhuistoren, de Montelbaanstoren en de toren van de Oude Kerk.
Reparatie van steun- en kapconstructies had vaak een andere reden: achterstallig onderhoud, te zware of onjuiste belasting, bouwfouten en krachtenwerking van buitenaf, zoals wind of andere krachten. De reparatie van de kap van de Burgerzaal in 1700 werd uitgevoerd vanwege een ondeugdelijke constructie en inwatering. Een voorbeeld van krachten van buitenaf vormt de ook in Amsterdam gevoelde aardbeving van Lissabon van 1 november 1755 en twee latere bevingen, in december van dat jaar en op 18 februari 1756. Deze aardschokken waren vermoedelijk de aanleiding dat het stadsbestuur kort hierna bouwvallige huizen in de stad liet slopen, en ook om de Montelbaanstoren en de Oosterkerk ingrijpend te herstellen.
De in dit artikel gepresenteerde voorbeelden laten zien dat er soms uiterst kostbare herstellingen moesten worden uitgevoerd om het voortbestaan van een gebouw te garanderen. Hiermee wordt tevens duidelijk dat dit soort herstel weliswaar kan worden ingegeven door een incident zoals een aardbeving, maar dat herstel een fenomeen is dat onlosmakelijk is verbonden met de lange levenscyclus van gebouwen