bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monocytes presenting a pro-inflammatory profile persist in patients submitted to a long-term pharmacological treatment after acute myocardial infarction
Authors: de Carvalho Daniel Carneiro , Fonseca Francisco Antonio Helfenstein , Izar Maria Cristina de Oliveira , Silveira Ana Luíza Pereira Assunção , Tuleta Izabela Dorota , do Amaral Jônatas Bussador , Neves Lucas Melo , Bachi André Luis Lacerda , França Carolina Nunes 
Published: January 2023

Introduction: Although it is broadly known that monocyte recruitment is involved in atherosclerosis development and that, in accordance with the microenvironment, these cells can be modulated into three well-known subpopulations: Classical (CD14++CD16−), intermediate (CD14++CD16+), and non-classical (CD14+CD16++), the effects of treatment with different pharmacological strategies (based on lipid-lowering and antiplatelets) after acute myocardial infarction upon the monocytes modulation and the role of the chemokine receptors CCR2, CCR5 and CX3CR1 in this context, are poorly understood.Methods: In this study, patients [n = 148, both men (n = 105, 71%) and women (n = 43, 29%)] submitted to treatment with a 2×2 factorial design, in which they received rosuvastatin 20 mg or simvastatin 40 mg plus ezetimibe 10 mg, as well as ticagrelor 90 mg or clopidogrel 75 mg were enrolled. Monocyte subsets were analyzed by flow cytometry at baseline (BL), and after one (1-M) and 6 months (6-M) of treatment.Results: Firstly, our results showed that, regardless of the treatment received, higher percentages of classical monocytes and lower of non-classical monocytes were found at the 6-M time point than BL values, whilst the percentage of intermediate monocytes was higher in all time points assessed than the other subsets. There were reductions in the CCR2 expression by non-classical and intermediate monocytes, without differences for the classical subtype. Concerning the CCR5 expression, there were reductions in the three monocyte subtypes, whereas the CX3CR1 expression increased both in intermediate and classical monocytes, without differences for non-classical monocytes. In relation to the treatment received, a higher percentage of intermediate monocytes at the 6-M time point than the values BL was observed in the group treated with simvastatin + ezetimibe + clopidogrel. No significant differences were found concerning non-classical, intermediate, and classical monocytes, for CCR2, CCR5, and CX3CR1 in the four treatment arms.Conclusion: Taken together, our results demonstrated that even under lipid-lowering and antiplatelet therapy for 6 months, the inflammatory phenotype of monocytes still persisted in the patients enrolled in this study.
Knowledge mapping of mitochondrial calcium uniporter from 2011 to 2022: A bibliometric analysis
Authors: Pan Deng , Xu Lin , Shi Dazhuo , Guo Ming 
Published: January 2023

Background: Calcium uptake research has a long history. However, the mitochondrial calcium uniporter (MCU) protein was first discovered in 2011. As investigations of mitochondrial calcium uniporter represent a new research hotspot, a comprehensive and objective perspective of the field is lacking. Hence, this bibliometric analysis aimed to provide the current study status and trends related to mitochondrial calcium uniporter research in the past decade.Methods: Articles were acquired from the Web of Science Core Collection database. We quantified and visualized information regarding annual publications, journals, cocited journals, countries/regions, institutions, authors, and cocited authors by using CiteSpace 5.8. R3 and VOSviewer. In addition, we analysed the citation and keyword bursts related to mitochondrial calcium uniporter studies.Results: From 2011 to 2022, 1,030 articles were published by 5,050 authors from 1,145 affiliations and 62 countries or regions. The country with the most published articles was the United States. The institution with the most published articles was the University of Padua. Rosario Rizzuto published the most articles and was also the most cocited author. Cell Calcium published the largest number of articles, whereas Journal of Biological Chemistry had the most cocitations. The top 5 keywords related to pathological processes were oxidative stress, cell death, permeability transition, apoptosis, and metabolism. MICU1, calcium, ryanodine receptor, ATP synthase and cyclophilin D were the top 5 keywords related to molecules.Conclusion: mitochondrial calcium uniporter research has grown stably over the last decade. Current studies focus on the structure of the mitochondrial calcium uniporter complex and its regulatory effect on mitochondrial calcium homeostasis. In addition, the potential role of mitochondrial calcium uniporter in different diseases has been explored. Current studies mostly involve investigations of cancer and neurodegenerative diseases. Our analysis provides guidance and new insights into further mitochondrial calcium uniporter research.
Scanning electron microscopy, biochemical and enzymatic studies to evaluate hydro-priming and cold plasma treatment effects on the germination of Salvia leriifolia Benth. seeds
Authors: Ghodsimaab Seyedeh Parisa , Makarian Hassan , Ghasimi Hagh Ziba , Gholipoor Manoochehr 
Published: January 2023

Finding a suitable method to increase seed germination rates of medicinal plants is critical to saving them from extinction. The effects of cold plasma (CP) treatments (using surface power densities of 80 and 100 W, with exposure times of 0, 120, 180, and 240 s) and incorporating hydropriming (carried out for 24 and 2 h on normal and uncovered seeds, respectively) to enhance the seed germination of Salvia leriifolia Benth a native endangered Iranian medicinal plant, were evaluated in this study. Scanning electron microscopy (SEM) images identified more destroyed mesh-like structures in hydro-primed and uncovered seeds than in normal and dry seeds. In comparison to the control, and other treatments, employing 100 W of CP for 240 s produced the maximum germination percentage and rate, as well as a seedling vigor of I and II in hydro-primed and uncovered seeds. The levels of α-amylase activity increased when the power and exposure times of CP were increased. The uncovering and hydropriming of S. leriifolia seeds resulted in increased enzyme activity. Malondialdehyde (MDA) and hydrogen peroxide (H2O2) contents were enhanced by increasing the power and exposure time of CP, especially in uncovered and hydro-primed seeds. The activity of antioxidant enzymes, including catalase (CAT) and superoxide dismutase (SOD), was correlated to changes in MDA and H2O2 levels. Finally, direct contact of CP with uncovered seeds in a short exposure time can improve the germination of S. leriifolia seeds via microscopic etching and activation of enzymes.
Divergent coupling mechanism of precipitation on plant community multifunction across alpine grassland on the Tibetan Plateau
Authors: Liu Miao , Li Yang , Sun Le , Du Ziyin , Li Wencheng , Zhang Lin , Wang Jinniu , Chen Ji 
Published: January 2023

IntroductionIt is essential to understand plant adaptive strategies on plant stoichiometric traits at the species level rather than at the community level under various environmental conditions across the Tibetan Plateau (TP).MethodsHere, plant community function and edaphic and meteorological factors were collected at 111 sites along an extensive water–heat gradient during the peak growing season in 2015. Community-weighted mean trait (CWM) was introduced to illuminating dynamics of the functional trait at the community level.ResultsOur results indicated that plant functional traits, including CWM-leaf total carbon (CWM_LTC), CWM-leaf total nitrogen (CWM_LTN), and CWM-leaf total phosphorus (CWM_LTP), showed similar and comparatively marked increases from alpine meadow (AM) to alpine steppe (AS). Moreover, since the tightly coordinated variation among each plant functional trait of AM was higher than that of AS, a more stable coupling mechanism of these plant functional traits could be observed in AM under a long-term evolutionary habit. Specifically, there was higher annual mean precipitation (AMP) in AM than that in AS significantly (P &lt; 0.01), and AMP was significantly correlated with soil moisture and soil total phosphorus in AM. Generally, our findings suggest that precipitation determines divergent coupling plant community function in both AS and AM.
Gender differences in professional social responsibility: Are women more responsible at work than men?
Authors: Reig-Aleixandre Natalia , García-Ramos José Manuel , De la Calle-Maldonado Carmen 
Published: January 2023

IntroductionThere is overwhelming evidence that companies with women on their boards of directors have higher levels of Corporate Social Responsibility. The relation between professional women and collective or organisational responsibility has been widely studied. However, to date there has been little research into the individual attitudes of women towards social responsibility. The purpose of this study is to analyse the differences in attitudes towards social responsibility between men and women in their professional life.MethodsA study sample (N = 524; 347 women; Medad = 37) was assembled using the LinkedIn social media platform and participants, after providing their informed consent, were asked to answer the Professional Social Responsibility Questionnaire.ResultsThe results showed significant differences in Professional Social Responsibility between men and women, with moderate effect (t(522) = 2.078; p = 0.038; η2 = 0.191), in favour of women. The women participants scored higher in the dimensions Discovery of Personal Values (t(522) = 2.342; p = 0.020; η2 = 0.216) and Social Awareness (t(522) = 2.179; p = 0.030; η2 = 0.201), both with representative effect sizes.DiscussionThese results suggest that the greater commitment to Corporate Social Responsibility of companies with women on their boards of directors is due, in part, to the greater individual or personal social responsibility of women. Higher levels of Discovery of Personal Values and Social Awareness amongst women may also result in better decision-making, ultimately accruing to the benefit of the company in terms of its financial results and reputation.
Validity and reliability of the Indonesian version of the Scale for the Assessment of Negative Symptoms
Authors: Amin Mustafa M. , Effendy Elmeida , Camellia Vita , Saragih Munawir , Kamil Ahmad , Harsono Rusly 
Published: January 2023

BackgroundNegative symptoms have long been conceptualized as a core aspect of schizophrenia. Despite widespread recognition of the status of these symptoms as independent dimensions of schizophrenia, they are sometimes difficult to distinguish from depression or cognitive impairment. Therefore, objective assessment of schizophrenia symptoms is critical by obtaining a valid and reliable Indonesian version of the SANS instrument. This study aimed to determine the content validity, concurrent, internal consistency reliability, inter-rater, cut-off value, sensitivity, and specificity of the SANS instrument.MethodsThis is a diagnostic study using the cross-sectional method to determine the relationship between the SANS and PANSS instruments on the negative symptom subscale. It was located at the Prof. Dr. M. Ildrem Mental Hospital of North Sumatera Province.ResultsOf the 400 subjects, 67.5% were males, and the median age of the subjects was 37 years (18–45). The results of the content validity test were good (mean I-CVI=1.00), and the concurrent validity test comparing the SANS and PANSS instruments on the negative symptom subscale obtained significant results (p &lt; 0.001) with a strong correlation (r = 0.763). Additionally, the consistency reliability test had a very high internal score (Cronbach alpha = 0.969), the overall inter-rater reliability test was “very good” (ICC = 0.985), and the cut-off value was 10.5 with sensitivity and specificity values of 72.9 and 77.9%, respectively.ConclusionThe Indonesian version of the SANS instrument is valid and reliable for measuring negative symptoms in people with schizophrenia in Indonesia.
Are serum levels of inflammatory markers associated with the severity of symptoms of bipolar disorder?
Authors: Wu Xiuhua , Chen Zhongcheng , Liao Yingtao , Yang Zhihua , Liang Xiaolin , Guan Nianhong , Gan Zhaoyu 
Published: January 2023

BackgroundTo explore the relationship between serum levels of inflammatory markers and symptomatic severity of bipolar disorder (BD).Materials and methodsA cross-sectional study was conducted on 126 BD patients with current depressive episode (BDD), 102 BD patients with current mixed or (hypo)manic episode (BDM) and 94 healthy controls (HC). All participants were drug-naïve and had no current active physical illness associated with inflammatory response or history of substance abuse. Fasting serum levels of CRP, leptin (LEP), adiponectin (ADP), visfatin (VIS), TNF-α, IL-2, IL-6, IL-10, IL-17), and monocyte chemoattractant protein-1 (MCP-1) were measured with enzyme-linked immunosorbent assay (ELISA). Symptomatic severity of BD was assessed with HAMD-17 and YMRS. Generalized linear model was used to determine the association between the serum levels of inflammatory markers and symptomatic severity of BD.ResultsThe serum levels of IL-6, IL-10 and IL-17, and the IL-6/IL-10 ratio were significantly lower in mild BDD than in HC. In moderate BDD, the serum levels of MCP, IL-6 and IL-17 were significantly lower than in HC. In severe BDD, the serum level of ADP, MCP-1, IL-10 and IL-17and the IL-17/IL-10 ratio were significantly lower than in HC. The serum levels of TNF-α and the IL-6/IL-10 ratio were significantly higher in mild BDM than in HC. In moderate BDM, the serum level of VIS, IL-2, and IL-17 were significantly higher than in HC, but the IL-6/IL-10 ratio was significantly lower than in control. In severe BDM, the serum levels of IL-6 and IL-17 and the ratios of IL-6/IL-10 and IL-17/IL-10 were significantly lower than in HC, but the neutrophil/lymphocyte ratio was significantly higher than in HC.ConclusionIn BDD, immune-inhibition is persistently predominant, while in mild-to-moderate BDM, immune system is activated but inhibited in severe BDM. The dynamic change of serum inflammatory markers suggests that alteration of peripheral inflammatory markers in BD is state-dependent instead of trait-marked.
Exploring core mental health symptoms among persons living with HIV: A network analysis
Authors: Han Shuyu , Zhang Yizhu , Yang Xianxia , Li Ke , Zhang Lili , Shao Ying , Ma Jianhong , Hu Yan , Zhu Zheng , Zhang Yukun , Wang Zhiwen 
Published: January 2023

ContextPersons living with HIV (PLWH) commonly experience mental health symptoms. However, little is known about the core mental health symptoms and their relationships.ObjectiveThis study aimed to evaluate the prevalence of various mental health symptoms and to explore their relationships in symptom networks among PLWH.MethodsFrom April to July 2022, we recruited 518 participants through convenience sampling in Beijing, China, for this cross-sectional study. Forty mental health symptoms, including six dimensions (somatization symptoms, negative affect, cognitive function, interpersonal communication, cognitive processes, and social adaptation), were assessed through paper-based or online questionnaires. Network analysis was performed in Python 3.6.0 to explore the core mental health symptoms and describe the relationships among symptoms and clusters.ResultsOf the 40 mental health symptoms, the most common symptoms were fatigue (71.2%), trouble remembering things (65.6%), and uncertainty about the future (64.0%). In the single symptom network, sadness was the most central symptom across the three centrality indices (rS = 0.59, rC = 0.61, rB = 0.06), followed by feeling discouraged about the future (rS = 0.51, rC = 0.57, rB = 0.04) and feelings of worthlessness (rS = 0.54, rC = 0.53, rB = 0.05). In the symptom cluster network, negative affect was the most central symptom cluster across the three centrality indices (rS = 1, rC = 1, rB = 0.43).ConclusionOur study provides a new perspective on the role of each mental health symptom among PLWH. To alleviate the mental health symptoms of PLWH to the greatest extent possible and comprehensively improve their mental health, we suggest that psychological professionals pay more attention to pessimistic mood and cognitive processes in PLWH. Interventions that apply positive psychology skills and cognitive behavioral therapy may be necessary components for the mental health care of PLWH.
Role of rumination and hope on negative life events and suicidal ideation under the background of normalization of pandemic prevention and control: A moderated mediation model
Authors: Yao Yingying , Qiao Zhihong , Dong Fangbai , Ni Jianchao 
Published: January 2023

IntroductionThe study aimed to investigate the impact and mechanism of negative life events on college students' suicidal ideation during the COVID-19 pandemic and the buffering effect of hope under the background of normalization of pandemic.MethodsA total of 5211 participants took part in this study. Self-reported negative life events, rumination, hope and suicide ideation were measured using a range of questions and scales. Our research demonstrated that the incidence of suicidal ideation among college freshmen in the past week was higher during the COVID-19 pandemic than that before the pandemic. In this study, conditional process model 15 was used to verify the hypothetical model of rumination as a potential mediator and hope as a moderator.ResultsThe hypothesized moderated mediation model was verified significant (β = -0.047, 95% CI = [-0.061, -0.035]), and hope was found to moderate the direct effect of negative life events on suicidal ideation (β = -0.039, t = -2.937, 95% CI = [-0.065, -0.013]) as well as the indirect effect of through the mediator rumination (β = -0.134, t = -10.850, 95% CI = [-0.158, -0.110]).DiscussionWe found that rumination partially mediated the effect of negative life events on suicidal ideation, and hope buffered the direct and indirect effect of negative life events on suicidal ideation. The implications of the findings for clinical interventions are discussed, including the importance of hope arousal as a protective factor and rumination as a cognitive mechanism for emotion regulation under the background of normalization of pandemic.
Cross-Section Observational Study to Assess Antimicrobial Resistance Prevalence among Bovine Respiratory Disease Bacterial Isolates from Commercial US Feedlots
Authors: Jobman Erin , Hagenmaier Jacob , Meyer Nathan , Harper Lee Bob , Taylor Lisa , Lukasiewicz Kip , Thomson Dan , Lowe James , Terrell Shane 
Published: January 2023

Antimicrobial resistance (AMR) is a global public health threat that jeopardizes efficacy of antibiotics in veterinary and human medicine. Antibiotics are commonly administered to target the bacterial component of bovine respiratory disease (BRD). The objectives of this study were to obtain a better understanding of antibiotic resistance in BRD-associated bacteria (Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni), investigate the clinical significance of AMR by monitoring clinical outcomes, and determine if regional differences exist in AMR trends. Deep pharyngeal swabs were used to sample beef cattle at initial BRD diagnosis (n = 453) from US feedlots representing three geographic regions. Organisms were identified by bacterial culture and subjected to broth microdilution antimicrobial susceptibility testing. Bacterium prevalence include P. multocida (36.0%), M. haemolytica (32.7%), and H. somni (28.5%). Of the Histophilus isolates, 39.5% were resistant to at least one antimicrobial, compared to 11.7% and 8.8% Pasteurella and Mannheimia, respectively. Non-susceptibility across all organisms was 5.7 X more likely in animals that received metaphylaxis, than those that did not (p < 0.0001; OR 5.7; CI 2.6–12.5). During days on feed 21–40, non-susceptibility of Histophilus was 8.7 X more likely than Mannheimia (p = 0.0002; OR 8.7; CI 2.8 to 27.4) and 6 X more likely than Pasteurella (p = 0.0016; OR 6.0; CI 2.0–18.0).
Design for performance improvement via structure optimization and contact engineering in MoS2 FETs with 2 nm gate length
Authors: Wang Fei , Ma Xiaolei , Chen Jiezhi 
Published: January 2023

Abstract
To provide theoretical designs for performance improvement, MoS2-based FETs with 2 nm gate length are investigated by numerical simulations. It is found that by optimizing structure with underlap (UL), off-current (I
off) is suppressed by ∼103 in MoS2 FETs. Contact engineering by H-passivation could modulate the Schottky barrier for higher on-current (I
on) and lower subthreshold swing in Si-MoS2 FETs. More importantly, even in Si-MoS2 FETs with 2 nm gate length, ∼107
I
on/I
off could be achieved by structure optimization to suppress I
off and contact engineering to modulate the Schottky barrier. Our results are significant to guide designs of MoS2 integrations in ultimate-scaled technology.
SÍNDROME DE NONNAN: RELAÇÃO DE UM TREINAMENTO MOTOR E SUAS CONSEQUÊNCIAS NAS ALTERAÇÕES OFTALMOLÓGICAS
Authors: Castilho Rosemeire Ribeiro , Rogero Cássia Schiffer , Silveira Ivaneide Pereira de Souza , Grillo Denise Elena 
Published: January 2023

O Objetivo deste estudo é observar se intervenções em Atividades Físicas com movimentos e solicitações específicas para uma criança de 11 anos, com síndrome de Nonnan podem auxiliar na melhoria das alterações oculares que esta criança apresenta. Neste relato de caso, uma menina de 11 anos com a síndrome, após treinos específicos em aulas de Educação Física, como solicitações de movimentos de lateralidade, deslocamentos anteroposteriores, manipulação de objetos coloridos e de formatos diferentes, e exploração de espaços diversos, observou-se as alterações optométricas, nesta paciente. Em cada atividade foi solicitado que a criança observasse e fizesse movimentos com a cabeça e globo ocular, na intenção de procurar, exatamente, os locais que deveriam ser atingidos pela participante, bem como os locais onde deveriam ser colocados e recolocados os objetos manipulados. Foram observados por meio de testes na optometria, antes e depois das atividades se houve melhoria no desenvolvimento das alterações oculares. Um ponto importante de se relatar é que a paciente, com orientação da optometrista, executou as atividades motoras e funcionais com um tampão no olho esquerdo, para estimular olho direito onde ela apresenta dificuldade. Os resultados observados nos trazem à conclusão que, com as atividades físicas realizadas foram trabalhados o sistema pulvinar advindos pela concentração, motivação, atenção e foco como solicitados nas atividades físicas acima. Nas atividades físicas pudemos, também, observar a evolução do aspecto neuro visual do sistema pulvinar (Rhein, 2019), por meio das atividades de concentração em cores, tamanhos diferentes de materiais, observação de distancias percorridas pela paciente.
Recebido em: 29/11/2022
Reformulado em: 14/12/2022
Aceito em: 14/12/2022