bluuebunny/crossref_metadata_2025_split huggingface dataset:
CLASS TOGETHER IN REALIZING THE VALUES OF MODERATION OF ISLAMIC EDUCATION THROUGH MULTICULTURAL SCHOOL CULTURE
Authors: Firmansyah Firmansyah 
Published: July 2023

Sultan Iskandar Muda High School in Medan under the auspices of The Sultan Iskandar Muda College Foundation located on Tengku Amir Hamzah Pekan I Sunggal Street, Medan Sunggal District, Medan Municipality. Sultan Iskandar Muda High School has its own uniqueness such as 1) Religion:religions recognized by the government such as Islam, Christianity, Buddhism, and Hinduism are in this school, Furthermore, mosques, churches, temples, and temples are built permanently in this school. 2) Â Culture:the diversity oflanguages, traditions, values, beliefs, myths, norms, and various tribes such as batak, Javanese, Chinese, Tamil, Mandailing, Malay, Karo, Aceh, Padang, Nias, Sunda, Banten Palembang, Ambon and Pakistan are in this school. Â This study aims Â first: Â to describe the values of moderation of Islamic education through multicultural school culture. This study uses qualitative type with Crasswell realist ethnography approach. Data collection techniques with participant observation techniques, in-depth interviews, and documentation. The result of this study is a joint class embodying the values of moderation of Islamic education through the culture of multicultural schools at SMA Sultan Iskandar Muda the first open values, secondly the value of dialogue, the third tolerance and the fourth is not extreme in religion.Keywords:Â tolerance, dialogue, open and not extreme in religion
VALUE OF MULTICULTURAL ISLAMIC EDUCATIONAT PATRA DHARMA BALIKPAPAN HIGH SCHOOL
Authors: Kusnan Kusnan 
Published: July 2023

This article aimed to describe value ofÂ multicultural islamic educationat patra dharma balikpapan high school . Due to the fact that Patra Dharma Balikpapan High School as an educational institution located in a diverse social environment has an awareness of its responsibility in maintaining togetherness in diversity. This study was conducted as a case study in Senior High School Of Patra Dharma which in practice have instilled the values of multicultural Islamic education. To analyze the event by collecting data through Interview technique, Observation, Documents, Audiovisual And Digital Materials and narrated in the form of qualitative-descriptive with descriptive interpretative analysis. The results of this study indicated therefore diversity must be responded to in the concept of education. For the ability of this goal, it is a value that must be developed, and those values are the values of multicultural Islamic education. These values include; as-samhiyah (tolerance), Al-musawwa (equal rights), tawazzun (equality), and ta'awun (mutual help). The values of multicultural Islamic education are the capital of social values that are crucial in building togetherness in diversity.Keywords:Â Values of Multicultural, Multicultural Islamic Education, Islamic Education
ISLAMIC EDUCATION CONSTRUCTION RAHMATAN LIL'ALAMIN IN THE PERSPECTIVE OF ISLAMIC RELIGIOUS FIGURES IN MALANG
Authors: Abrori Ali Mukhammad 
Published: July 2023

The Islamic Society of Malang, has pattern various forms of worship and da'wah . Diversity this , in one aside bring goodness , because with diversity that , will add treasure science islam . Diversity method worship as well as a model of da'wah , can cause internal divisions of Muslims , if no be addressed by wise and wise . As effort ward off affiliated Islamic movement with radicalism and takfiri, some religious leaders in Malang indeed must campaign Rahmatan's Islamic Da'wah Lil'Alamin . In this case , there are several problems that are the focus of research as well as destination in research , namely (1) What is the view of Malang Islamic religious leaders about the concept of Islamic education Rahmatan Lil'Alamin? (2) How is the process of adapting the Islamic religious leaders in Malang, carrying out the process of realizing the teachings of love in the context of Rahmatan Lil'Alamin's Islamic education? (3) How do Islamic religious leaders in Malang carry out the process of internalizing the values of Rahmatan Lil'Alamin's Islamic education? . For that in writing dissertation this , author use type approach qualitative. From result study this that the figures have differences and similarities in views about the definition and concept of Islamic education Rahmatan Lil'Alamin . Meanwhile, the points of similarity regarding Rahmatan Lil'Alamin's concept of Islamic education are: Muslim leaders agree that every human being must spread love to all of God's creatures. Every citizen of different ethnicity, religion, race, and class, must live, tolerate each other, love one another. In the midst of the diversity of sects and understandings, Islamic religious leaders have carried out a process of adjustment and embodiment in relation to Rahmatan Lil'Alamin's Islamic education. In relation to the internalization process, how these figures provide real guidance to the Muslim community, in relation to Rahmatan Lil'Alamin's Islamic education.Keywords:Â Islamic Education Construction, Rahmatan Lil'Alamin, Perspective Islamic religious figures.
EXTERNALIZATION OF THE MULTICULTURAL ISLAMIC EDUCATION CURRICULUM AT SCHOOL
Authors: Sulistiono Muhammad , Maskuri Maskuri , Arief Nur Fajar 
Published: July 2023

This research discusses the externalization ofÂ multicultural Islamic education which has the same wedge in the realm of learning, namely a contextual approach.Â So that externalization is a process of material association with application in everyday life, namely returning to the values that guide the life of the community. The search for multicultural values that became the foundation for the founding of the school. Then it turned into a guideline by the citizens of the school that reflected the experience of multicultural values.Â Furthermore, it is used as a foundation in the multicultural Islamic religious education curriculum. Based on the researcher's findings on the focus of research on the externalization ofÂ the multicultural Islamic education curriculum in schools which includes several aspects, namely; (1) the phenomenon of ideas, (2) the phenomenon of history, (3) the phenomenon of the reaction of society, (4) the phenomenon of social products.Keywords:Â externalization, curriculum, multicultural Islamic education
OPTIMIZATION OF WATER RESOURCES UTILIZATION DISTRIBUTION FOR AGRICULTURAL BENEFITS IN THE CLAMPIS IRRIGATION AREA SAMPANG DISTRICT
Authors: Zabadi Fairus 
Published: July 2023

Utilization of water resources and management is an important factor and has a decisive role in order to increase production per plant in general and crop production in particular. In order to maintain self-sufficiency in food, it is necessary to make efforts to continuously increase the intensity of potential food crops. These efforts include optimizing the proper distribution of water utilization. Factors to determine the need for irrigation water include land preparation, consumptive use, percolation and seepage, replacement of water layers, and effective rainfall. While the method used in this study is optimization using a linear program using the Solver facility in Microsoft Excel with the aim of optimizing the availability of irrigation water so as to produce maximum profits and distribution of irrigation utilization that is more effective and efficient. From the optimization results using the Solver and Microsoft Excel tools, it can be seen that the maximum area of ​​land that can be planted with the available inflow at the intake for MTI (Rice I 2086 Ha/Tobacco II 667.54 Ha), MT-II (Rice I 667, 54 Ha/Tobacco I 1391 Ha/PolowijoI 567.35 Ha/Rice II 128.11 Ha), MT III (Polowijo I 323.65 Ha/Rice II 348.89 Ha/Tobacco II 1261.46 Ha/Polowijo II 825, 00) and provides an analysis of the maximum profit of agricultural products of Rp. 178,183,800,000.00,-.

Keywords: Linear Program Optimization; Utilization of Water Resources; Agricultural Benefits; Klampis Irrigation.
Behavioral changes and dendritic remodeling of hippocampal neurons in adolescent alcohol-treated rats
Authors: Sircar Ratna 
Published: July 2023

Objective: Earlier, we and others have reported that alcohol exposure in adolescent rat impaired performance of a spatial memory task in the Morris water maze. The goal of the present study was to investigate the effects of acute adolescent alcohol treatment on the hippocampus-dependent (contextual fear conditioning) and hippocampus-independent (cued fear) memories. The study also looked at the structural changes in anterior CA1 hippocampal neurons in adolescent alcohol-treated rats.Methods: Adolescent female rats were administered with a single dose of alcohol (1.0, 1.5, or 2.0 g/kg) or vehicle either before training (pre-training) or after training (pre-testing). Experimental and control rats were trained in the fear conditioning paradigm, and 24 h later tested for both contextual fear conditioning as well as cued fear memory. Separate groups of rats were treated with either alcohol (2 g/kg) or vehicle and sacrificed 24 h later. Their brains were harvested and processed for rapid Golgi staining. Randomly selected CA1 pyramidal neurons were analyzed for dendritic branching and dendritic spine density.Results: Pre-training alcohol dose-dependently attenuated acquisition of hippocampus-dependent contextual fear conditioning but had no effect on the acquisition of amygdala-associated cued fear. When administered following training (pre-testing), alcohol did not alter either contextual conditioning or cued fear memory. Golgi stained CA1 pyramidal neurons in alcohol treated female rats had reduced basilar tree branching and less complex dendritic arborization.Conclusion: Alcohol specifically impaired hippocampal learning in adolescent rats but not amygdala-associated cued fear memory. Compared to vehicle-treated rats, CA1 hippocampal pyramidal neurons in alcohol-treated rats had less complex dendritic morphology. Together, these data suggest that adolescent alcohol exposure produces changes in the neuronal organization of the hippocampus, and these changes may be related to impairments in hippocampus-dependent memory formation.
Cardiovascular changes in the NZB/W F1 mouse model of lupus nephritis
Authors: Böhme Romy , Daniel Christoph , Ferrazzi Fulvia , Angeloni Miriam , Ekici Arif Bülent , Winkler Thomas H. , Hilgers Karl-Friedrich , Wellmann Ute , Voll Reinhard E. , Amann Kerstin 
Published: July 2023

BackgroundPatients with systemic lupus erythematosus (SLE), an autoimmune disease, have a higher risk of cardiovascular (CV) disease and death. In addition, up to 40%–50% of SLE patients develop lupus nephritis (LN) and chronic kidney disease, which is an additional CV risk factor. Thus, the individual contributions of LN and other SLE-specific factors to CV events are unclear.MethodsIn this study, we investigated the effect of LN on the development of CV changes using the female NZBxNZW F1 (NZB/W) mouse model of lupus-like disease, with female NZW mice as controls. Standard serologic, morphologic, immunohistologic, and molecular analyses were performed. In a separate group of NZB/W mice, systolic blood pressure (BP) was measured during the course of the disease using tail plethysmography.ResultsOur data show marked CV changes in NZB/W mice, i.e., increased heart weight, hypertrophy of the left ventricle (LV) and septum, and increased wall thickness of the intramyocardial arteries and the aorta, which correlated with the progression of renal damage, but not with the age of the mice. In addition, systolic BP was increased in NZB/W mice only when kidney damage progressed and proteinuria was present. Pathway analysis based on gene expression data revealed a significant upregulation of the response to interferon beta in NZB/W mice with moderate kidney injury compared with NZB mice. Furthermore, IFI202b and IL-6 mRNA expression is correlated with CV changes. Multiple linear regression analysis demonstrated serum urea as a surrogate marker of kidney function and IFI202b expression as an independent predictor for LV wall thickness. In addition, deposition of complement factors CFD and C3c in hearts from NZB/W mice was seen, which correlated with the severity of kidney disease.ConclusionsThus, we postulate that the pathogenesis of CV disease in SLE is affected by renal impairment, i.e., LN, but it can also be partly influenced by lupus-specific cardiac expression of pro-inflammatory factors and complement deposition.
An investigation into teachers’ occupational well-being and education leadership during the COVID-19 pandemic
Authors: Duong Anh Chien , Nguyen Hong Nhung , Tran Anh , Trinh Thong Minh 
Published: July 2023

IntroductionThe COVID-19 pandemic has necessitated rapid adjustments by teachers to ensure effective education. This shift in circumstances has created a more challenging working environment for teachers, leading to growing concerns about their occupational well-being both nationally and globally. While adapting to change and sustaining professional well-being are crucial for teachers, it is equally important to address their well-being during the pandemic. This study aims to contribute to the existing literature by employing questionnaires and semi-structured interviews to explore the occupational well-being of in-service teachers in Hanoi, Vietnam. Additionally, it seeks to examine their perceptions of school leaders’ efforts to enhance teachers’ well-being during the COVID-19 pandemic.MethodsConvenience sampling was utilized to collect questionnaire data from 103 in-service teachers and lecturers in Hanoi, Vietnam, between 2021 and 2022. Moreover, a purposive sampling approach was employed to select eight participants for semi-structured interviews. The questionnaires and interviews formed the primary methods of data collection for this study.ResultsThe findings of this study indicate that, overall, the participants exhibited a moderate level of occupational well-being. It was also observed that the participants received support from school leaders in terms of professional development, flexibility, and well-being activities during the COVID-19 pandemic. These results provide valuable insights for teachers to understand their personal occupational well-being and contribute to institutional awareness.DiscussionThe outcomes of this study have significant implications for teachers and principals. They shed light on the promotion of teachers’ occupational well-being during this critical period. Furthermore, the study illustrates how education stakeholders can play a role in enhancing teachers’ well-being. The discussion delves into the importance of personal occupational well-being and institutional awareness, emphasizing the need for collaboration among various stakeholders to create a conducive environment for teachers.
Serum folic acid: an effective indicator for arteriogenic erectile dysfunction
Authors: Feng Xingliang , Mei Yangyang , Xie Pinpeng , Xing Zhaoyu , Wang Xiaogang , Cui Li , Xu Renfang 
Published: July 2023

BackgroundThe present study is the first to explore the correlation between serum folic acid (FA) level and penile arterial peak systolic velocity (PSV) as measured via penile color Doppler ultrasonography (PDU), which directly reflects endothelial function in the penile artery.Materials and methodsA total of 244 consecutive erectile dysfunction (ED) patients and 72 healthy controls, recruited from the Andrology department and the Healthy Physical Examination Center of our hospital, respectively, from June 2020 to April 2022, were included in the study. Serum FA was measured in ED patients and healthy controls, and PDU examinations were conducted for all eligible ED patients. The Pearson method was used to evaluate the correlation between FA levels and PDU parameters in ED patients. A receiver operating characteristic (ROC) curve analysis was also performed to calculate the sensitivity and specificity of these parameters for prediction of arteriogenic ED.ResultsAfter the PDU test, the average serum FA level among patients diagnosed with arteriogenic ED was 8.08 ± 2.64 ng/ml, lower than the average of 10.78 ± 2.87 ng/ml among healthy controls. There were no statistically significant inter-group differences on any basic parameters, including age, body mass index, fasting blood glucose, total cholesterol, and triglyceride. For further analysis, we divided the arteriogenic ED group into three subgroups by PSV range to compare serum FA levels among these subgroups. The mean FA levels in each of these groups were 5.97 ± 1.51ng/ml, and 8.21 ± 2.37ng/ml, and 10.55 ± 2.56ng/ml, while the corresponding PSV values were 15.75 ± 2.39cm/s, 23.53 ± 2.19cm/s, and 32.72 ± 1.64cm/s. Overall, a positive correlation between PSV and FA level was found among patients with arteriogenic ED (r=0.605, P&lt;0.001). Furthermore, when FA level was used, with a cut-off value of 10.045 ng/ml, as a criterion to distinguish patients with arteriogenic ED from healthy controls, the area under the curve (AUC) was 0.772 (95% confidential interval: [0.696, 0.848]), for a sensitivity of 0.611 and specificity of 0.824.ConclusionSerum FA level is positively correlated with PSV in ED patients, and has the ability to distinguish patients with arteriogenic ED from healthy controls. Taking these findings together, FA deficiency should be regarded as an independent risk factor for arteriogenic ED.
Predictors and a prediction model for positive fine needle aspiration biopsy in C-TIRADS 4 thyroid nodules
Authors: Yang Zhijie , Gao Xin , Yang Lu 
Published: July 2023

ObjectivesTo screen out the predictors and establish a prediction model of positive fine needle aspiration biopsy (FNAB) in the Chinese Guidelines for Malignant Risk Stratification of Thyroid Nodule Ultrasound (C-TIRADS) 4 thyroid nodules, and this nomogram can help clinicians evaluate the risk of positive FNAB and determine if FNAB is necessary.MethodsWe retrospectively analyzed data from 547 patients who had C-TIRADS 4 thyroid nodules and underwent fine-needle aspiration biopsy (FNAB) at the Second Affiliated Hospital of Chongqing Medical University between November 30, 2021 and September 5, 2022. Patients who met our inclusion criteria were divided into two groups based on positive or negative FNAB results. We compared their ultrasound (US) features, BRAF V600E status, thyroid function, and other general characteristics using univariate and multivariate logistic regression analyses to identify independent predictors. These predictors were then used to construct a nomogram. The calibration plot, area under the curve (AUC), and decision curve analysis were employed to evaluate the calibration, discrimination, and clinical utility of the prediction model.ResultsOut of 547 patients, 39.3% (215/547) had a positive result on fine-needle aspiration biopsy (FNAB), while 60.7% (332/547) had a negative result. Univariate logistic regression analysis revealed no significant differences in TPOAb, TgAb, TSH, Tg, nodule location, sex, or solid status between the two groups (P&gt;0.05). However, age, nodule size, internal or surrounding blood flow signal, microcalcifications, aspect ratio, morphology, and low echo showed significant differences (P&lt;0.05). Multivariate logistic regression analysis was conducted to explore the correlation between potential independent predictors. The results showed that only age (OR=0.444, 95% Cl=0.296~0.666, P&lt;0.001), low echo (OR=3.549, 95% Cl=2.319~5.432, P&lt;0.001), microcalcifications (OR=2.531, 95% Cl=1.661~3.856, P&lt;0.001), aspect ratio (OR=3.032, 95% Cl=1.819~5.052, P&lt;0.001), and morphology (OR=2.437, 95% Cl=1.586~3.745, P&lt;0.001) were independent predictors for a positive FNAB. These variables were used to construct a prediction nomogram. An ROC curve analysis was performed to assess the accuracy of the nomogram, and AUC=0.793, which indicated good discrimination and decision curve analysis demonstrated clinical significance within a threshold range of 14% to 91%.ConclusionIn conclusion, 5 independent predictors of positive FNAB, including age (≤45 years old), low echo (yes), microcalcifications (yes), aspect ratio (&gt;1) and morphology (irregular), were identified. A nomogram was established based on the above 5 predictors, and the nomogram can be used as a complementary basis to help clinicians make decisions on FNAB of C-TI-RADS 4 thyroid nodules.
Effects of body mass index and insulin resistance on first-time assisted conception and perinatal outcomes in young polycystic ovary syndrome patients
Authors: Guo Jiayu , Chen Yuanhui , Jiang Yilin , Zhang Cuilian 
Published: July 2023

ObjectiveThe objective of the study was to explore the effect of body mass index (BMI) and insulin resistance (IR) levels on first-time assisted conception results and perinatal outcomes in young polycystic ovary syndrome (PCOS) patients.DesignThis was a single-center, retrospective, observational cohort study.PatientsYoung women with PCOS undergoing their first embryo transfer were included in the study.Main outcome measureEarly pregnancy loss rate was the main outcome measure.ResultsThe early pregnancy loss rate in the overweight + insulin resistance group (OW+IR group) was significantly higher than that in the non-overweight + non-insulin resistance group (NOW+NIR group) (18.16% vs. 9.02%, Bonferroni correction, P = 0.012). The early pregnancy loss rate in the non-overweight + insulin resistance group (NOW+IR group) and overweight + non-insulin resistance group (OW+NIR group) (18.18% and 17.14%, respectively) were also higher than that in the NOW+NIR group (6.07%), but the difference was not statistically significant (Bonferroni correction, all P &gt; 0.05). No significant difference was found in clinical pregnancy rate, live birth rate, and macrosomia rate (all P &gt; 0.05). After adjusting for confounding factors, BMI and IR levels were identified as independent risk factors for early pregnancy loss rate.ConclusionBMI and IR levels are independent risk factors for early pregnancy loss in young PCOS patients during the first embryo transfer cycle. Multiple indicators should be considered when assessing pregnancy outcomes, which will promote individualized pregnancy guidance and treatment procedures for PCOS patients.
Self-assembled GLP-1/glucagon peptide nanofibrils prolong inhibition of food intake
Authors: Ouberai Myriam M. , Gomes Dos Santos Ana L. , Kinna Sonja , Hornigold David C. , Baker David , Naylor Jacqueline , Liang Lihuan , Corkill Dominic J. , Welland Mark E. 
Published: July 2023

IntroductionOxyntomodulin (Oxm) hormone peptide has a number of beneficial effects on nutrition and metabolism including increased energy expenditure and reduced body weight gain. Despite its many advantages as a potential therapeutic agent, Oxm is subjected to rapid renal clearance and protease degradation limiting its clinical application. Previously, we have shown that subcutaneous administration of a fibrillar Oxm formulation can significantly prolong its bioactivity in vivo from a few hours to a few days.MethodsWe used a protease resistant analogue of Oxm, Aib2-Oxm, to form nanfibrils depot and improve serum stability of released peptide. The nanofibrils and monomeric peptide in solution were characterized by spectroscopic, microscopic techniques, potency assay, QCM-D and in vivo studies.ResultsWe show that in comparison to Oxm, Aib2-Oxm fibrils display a slower elongation rate requiring higher ionic strength solutions, and a higher propensity to dissociate. Upon subcutaneous administration of fibrillar Aib2-Oxm in rodents, a 5-fold increase in bioactivity relative to fibrillar Oxm and a significantly longer bioactivity than free Aib2-Oxm were characterized. Importantly, a decrease in food intake was observed up to 72-hour post-administration, which was not seen for free Aib2-Oxm.ConclusionOur findings provides compelling evidence for the development of long-lasting peptide fibrillar formulations that yield extended plasma exposure and enhanced in vivo pharmacological response.