bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic cell tracking using time‐lapse MRI with variable temporal resolution Cartesian sampling
Authors: Armstrong Mark , Wilken Enrica , Freppon Felix , Masthoff Max , Faber Cornelius , Xiao Dan 
Published: July 2023

AbstractPurposeTemporal resolution of time‐lapse MRI to track individual iron‐labeled cells is limited by the required data‐acquisition time to fill k‐space and to reach sufficient SNR. Although motion of slowly patrolling monocytes can be resolved, detection of fast‐moving immune cells requires improved acquisition and reconstruction strategies.Theory and MethodsFor accelerated MRI cell tracking, a Cartesian sampling scheme was designed, in which the fully sampled and undersampled k‐space data for different acceleration factors were acquired simultaneously, and multiple undersampling ratios could be chosen retrospectively. Compressed‐sensing reconstruction was applied using dictionary learning and low‐rank constraints. Detection of iron‐labeled monocytes was evaluated with simulations, rotating phantom experiments and in vivo mouse brain measurements at 9.4 T.ResultsFully sampled and 2.4‐times and 4.8‐times accelerated images were reconstructed and had sufficient contrast‐to‐noise ratio (CNR) for single cells to be resolved and followed dynamically. The phantom experiments showed an improvement in CNR of 6.1% per μm/s in the 4.8‐times undersampled images. Geometric distortion of cells caused by motion was visibly reduced in the accelerated images, which enabled detection of moving cells with velocities of up to 7.0 μm/s. In vivo, additional cells were resolved in the accelerated images due to the improved temporal resolution.ConclusionThe easy‐to‐implement flexible Cartesian sampling scheme with compressed‐sensing reconstruction permits simultaneous acquisition of both fully sampled and high temporal resolution images. The CNR of moving cells is effectively improved, enabling the recovery of high velocity cells with sufficient contrast at virtually no cost.
Invalidity of Tokyo guidelines in acute biliary pancreatitis: A multicenter cohort analysis of 944 pancreatitis cases
Authors: Juhász Márk Félix , Tóháti Rebeka , Jászai Viktória Adrienn , Molnár Regina , Farkas Nelli , Czakó László , Vincze Áron , Erőss Bálint , Szentesi Andrea , Izbéki Ferenc , Papp Mária , Hegyi Péter , Párniczky Andrea ,   the Hungarian Pancreatic Study Group
Published: July 2023

AbstractBackgroundThere is a noteworthy overlap between the clinical picture of biliary acute pancreatitis (AP) and the 2018 Tokyo guidelines currently used for the diagnosis of cholangitis (AC) and cholecystitis (CC). This can lead to significant antibiotic and endoscopic retrograde cholangiopancreatography (ERCP) overuse.ObjectivesWe aimed to assess the on‐admission prevalence of AC/CC according to the 2018 Tokyo guidelines (TG18) in a cohort of biliary AP patients, and its association with antibiotic use, ERCP and clinically relevant endpoints.MethodsWe conducted a secondary analysis of the Hungarian Pancreatic Study Group's prospective multicenter registry of 2195 AP cases. We grouped and compared biliary cases (n = 944) based on the on‐admission fulfillment of definite AC/CC according to TG18. Aside from antibiotic use, we evaluated mortality, AC/CC/AP severity, ERCP performance and length of hospitalization. We also conducted a literature review discussing each criteria of the TG18 in the context of AP.Results27.8% of biliary AP cases fulfilled TG18 for both AC and CC, 22.5% for CC only and 20.8% for AC only. Antibiotic use was high (77.4%). About 2/3 of the AC/CC cases were mild, around 10% severe. Mortality was below 1% in mild and moderate AC/CC patients, but considerably higher in severe cases (12.8% and 21.2% in AC and CC). ERCP was performed in 89.3% of AC cases, common bile duct stones were found in 41.1%.ConclusionAround 70% of biliary AP patients fulfilled the TG18 for AC/CC, associated with a high rate of antibiotic use. Mortality in presumed mild or moderate AC/CC is low. Each of the laboratory and clinical criteria are commonly fulfilled in biliary AP, single imaging findings are also unspecific—AP specific diagnostic criteria are needed, as the prevalence of AC/CC are likely greatly overestimated. Randomized trials testing antibiotic use are also warranted.
Life Experiences of Borderline Personality Disorder Survivors in the Recovery Process: A Qualitative Study
Authors: Sarwendah Endah Sarwendah , Suryani Suryani , Widianti Efri 
Published: July 2023

Background: Borderline Personality Disorder or BPD is a personality disorder with the main symptoms are emotional instability, impulsive behavior, negative self-concept, and impaired interpersonal function. Recovery in BPD is directed at the existence of satisfaction and meaning in life even with limited conditions due to symptoms of the disorder that still exists.Purpose: The aim of this study is to explore the life experiences of BPD survivors in their recovery processMethod: This research is a qualitative research with a phenomenological approach. In-depth interviews were conducted with 10 BPD survivors from the Indonesian BPD Community. Interview transcripts were analyzed using the Colaizzi method.Result: Six themes were extracted in this study, namely,Â the recovery process is not found alone, it is difficult to understand and love oneself, it is difficult to build stable relationships with others, the journey to make peace with oneself, the most painful experiences that come from the closest people and the experience of mental health services in Indonesia.Conclusion: The process of self-identification has been the first step in an individual's journey with BPD in the recovery process. The available support system has helped BPD survivors to be able to adapt to the experience resulting from BPD symptoms. It is necessary to increase the knowledge of nurses about BPD in order to be able to provide good nursing careKeyword: borderline personality disorder, life experience, recovery
The Efficacy of Translanguaging in Selected South African Mathematics and Science Intermediate Phase Classrooms
Authors: Ndhlovana Shalom Nokuthula , Charamba Erasmos 
Published: July 2023

The 2015 TIMSS and 2021 PIRLS results show the underachievement of our learners in reading comprehension, mathematics and science. Analysts of both assessments suggest the low performance is caused, chiefly, by the misalignment between learners’ home languages and the language of instruction. Even though today’s classrooms have become more and more culturally and linguistically diverse resulting in the majority of learners entering the classroom with a home language different from the language of instruction, the teaching of such learners still follows a monolingual trajectory. This has resulted in a drop- in the number of primary school learners exhibiting basic mathematics and scientific literacy in South Africa. Through semi-systemic review, the current study sought to explore the role language plays in concept comprehension among learners as well as examining the efficacy of translanguaging in mathematics and science classrooms. Eight studies were reviewed and results suggest that proficiency in the language of instruction plays a crucial role in comprehension of scientific and mathematical concepts. The study also shows the efficacy of translanguaging in enhancing the academic performance of learners and recommends the use of translanguaging within multilingual contexts.
Accelerated cystogenesis by dietary protein load is dependent on, but not initiated by kidney macrophages
Authors: Sedaka Randee , Huang Jifeng , Yamaguchi Shinobu , Lovelady Caleb , Hsu Jung-Shan , Shinde Sejal , Kasztan Malgorzata , Crossman David K. , Saigusa Takamitsu 
Published: July 2023

BackgroundDisease severity of autosomal dominant polycystic kidney disease (ADPKD) is influenced by diet. Dietary protein, a recognized cyst-accelerating factor, is catabolized into amino acids (AA) and delivered to the kidney leading to renal hypertrophy. Injury-induced hypertrophic signaling in ADPKD results in increased macrophage (MФ) activation and inflammation followed by cyst growth. We hypothesize that the cystogenesis-prompting effects of HP diet are caused by increased delivery of specific AA to the kidney, ultimately stimulating MФs to promote cyst progression.MethodsPkd1flox/flox mice with and without Cre (CAGG-ER) were given tamoxifen to induce global gene deletion (Pkd1KO). Pkd1KO mice were fed either a low (LP; 6%), normal (NP; 18%), or high (HP; 60%) protein diet for 1 week (early) or 6 weeks (chronic). Mice were then euthanized and tissues were used for histology, immunofluorescence and various biochemical assays. One week fed kidney tissue was cell sorted to isolate tubular epithelial cells for RNA sequencing.ResultsChronic dietary protein load in Pkd1KO mice increased kidney weight, number of kidney infiltrating and resident MФs, chemokines, cytokines and cystic index compared to LP diet fed mice. Accelerated cyst growth induced by chronic HP were attenuated by liposomal clodronate-mediated MФ depletion. Early HP diet fed Pkd1KO mice had larger cystic kidneys compared to NP or LP fed counterparts, but without increases in the number of kidney MФs, cytokines, or markers of tubular injury. RNA sequencing of tubular epithelial cells in HP compared to NP or LP diet group revealed increased expression of sodium-glutamine transporter Snat3, chloride channel Clcnka, and gluconeogenesis marker Pepck1, accompanied by increased excretion of urinary ammonia, a byproduct of glutamine. Early glutamine supplementation in Pkd1KO mice lead to kidney hypertrophy.ConclusionChronic dietary protein load-induced renal hypertrophy and accelerated cyst growth in Pkd1KO mice is dependent on both infiltrating and resident MФ recruitment and subsequent inflammatory response. Early cyst expansion by HP diet, however, is relient on increased delivery of glutamine to kidney epithelial cells, driving downstream metabolic changes prior to inflammatory provocation.
Perlindungan Hak Konsumen dalam Layanan e-Commerce melalui Sistem COD: Elaborasi dalam Kerangka Hukum Islam
Authors: Illa Nabillah  , Euis Fajriyah  , Firdaus  
Published: July 2023

Online buying and selling are a form of buying and selling activity that has its own characteristics, which utilizes the internet. Such conditions are very favorable to consumers on the one hand, because they provide an opportunity to have many choices in obtaining goods and services. After all, violations of consumer rights are possible. Therefore, it is necessary to protect consumer rights in buying and selling online. This study aims to analyze the protection of consumer rights in e-Commerce services through the COD system at JNE Galagamba-Ciwaringin-Cirebon and its elaboration within the framework of Islamic law. This research is a qualitative research with data collection using observation techniques, documentation, and interviews. Protection of consumer rights in e-commerce transactions through the COD system carried out at JNE Galagamba-Ciwaringin-Cirebon is basically in accordance with Islamic law because there are khiyar rights, namely the return of goods and funds. delivery of goods with the COD system where it has been carried out according to the procedure for customers who order online.
Preface: 4th International Conference on Educational Reform, Management Science and Sociology (ERMSS 2023)
Authors: Coleridge Antonia , Tong Fuyu 
Published: July 2023

2023 4th International Conference on Educational Reform, Management Science and Sociology (ERMSS 2023) was successfully held online during January 7-8, 2023 in Detroit, USA. This conference aims to become a springboard for research, innovation and entrepreneur sharing several key technological developments and emerging applications of informatization in education technology, information management, engineering management, business management and public management.
ERMSS 2023 invited scholars and experts in related fields from various universities to participate in the review and guidance of this conference. The conference focuses on the latest research fields, and aims to provide an international cooperation and exchange platform for experts, scholars and business managers to share their research achievements, discuss the key challenges and research directions of the development, and jointly promote the industrialization cooperation and continuous innovation of international academic achievements. This collection of proceedings compiles oral and paper presentations submitted by the authors and scrutinized by the special committee.
Organizing Committees of ERMSS
Detroit, USA
Ligand‐Induced Cation–π Interactions Enable High‐Efficiency, Bright, and Spectrally Stable Rec. 2020 Pure‐Red Perovskite Light‐Emitting Diodes
Authors: Zhang Jibin , Cai Bo , Zhou Xin , Yuan Fanglong , Yin Chunyang , Wang Heyong , Chen Hongting , Ji Xinzhen , Liang Xiangfei , Shen Chao , Wang Yu , Ma Zhuangzhuang , Qing Jian , Shi Zhifeng , Hu Zhangjun , Hou Lintao , Zeng Haibo , Bai Sai , Gao Feng 
Published: July 2023

AbstractAchieving high‐performance perovskite light‐emitting diodes (PeLEDs) with pure‐red electroluminescence for practical applications remains a critical challenge because of the problematic luminescence property and spectral instability of existing emitters. Herein, high‐efficiency Rec. 2020 pure‐red PeLEDs, simultaneously exhibiting exceptional brightness and spectral stability, based on CsPb(Br/I)3 perovskite nanocrystals (NCs) capping with aromatic amino acid ligands featuring cation–π interactions, are reported. It is proven that strong cation–π interactions between the PbI6‐octahedra of perovskite units and the electron‐rich indole ring of tryptophan (TRP) molecules not only chemically polish the imperfect surface sites, but also markedly increase the binding affinity of the ligand molecules, leading to high photoluminescence quantum yields and greatly enhanced spectral stability of the CsPb(Br/I)3 NCs. Moreover, the incorporation of small‐size aromatic TRP ligands ensures superior charge‐transport properties of the assembled emissive layers. The resultant devices emitting at around 635 nm demonstrate a champion external quantum efficiency of 22.8%, a max luminance of 12 910 cd m−2, and outstanding spectral stability, representing one of the best‐performing Rec. 2020 pure‐red PeLEDs achieved so far.
Estimating reliability for evaluating nitrate accumulation in sorghum (Sorghum bicolor L. Moench) inbred A‐lines
Authors: Ralston Shayln R. , Rooney William L. , Boerman Nicholas A. 
Published: July 2023

AbstractSorghum is an important forage crop in many cropping systems. Nitrate can accumulate in the vegetative plant tissue to levels high enough that result in fatality when fed to ruminant livestock when grown under high nitrate conditions. If variation among inbred lines can be documented for nitrate concentration, it may be possible to reduce nitrate accumulation within forage sorghum hybrids by selecting inbred lines having lower nitrate accumulation. The goal of this study was to evaluate a diverse set of male‐sterile sorghum inbred lines grown under high nitrate conditions, to observe if genotypic variation exists among lines used to produce forage sorghum hybrids. Forty replicates of 20 sorghum A‐lines were grown in a greenhouse and received either 272 kg ha−1 or 408 kg ha−1 of actual nitrogen per plant through applications of ammonium nitrate. Variance components were extracted from linear regression models and reliability was estimated on an entry‐mean basis. Leaf and stem reliability estimates were 0.95 and 0.93, respectively. These reliability estimates indicate the genetic variance comprised most of the phenotypic variance, and that our measurements were consistent. Significant differences were also observed between genotypes for both leaf and stem tissue. Therefore, sufficient genetic variance exists for developing male sterile sorghum inbred lines having leaf nitrate concentrations below the potentially lethal toxicity threshold of 10,000 μg g−1.
L5 spondylolysis: Anatomical study comparing healed and unhealed lesions
Authors: Grayson Viktoriya S. , Couldwell Mitchell W. , Shekhawat Devendra , Chaiyamoon Arada , Cardona Juan J. , Keshavarzi Sassan , Iwanaga Joe , Dumont Aaron S. , Tubbs R. Shane 
Published: July 2023

AbstractThe anatomy and pathogenesis of spondylolysis has been widely studied; however, the microanatomy of spondylolysis of the lumbar vertebra has not been well described. Therefore, we aim to better elucidate this anatomy. Twenty dry bone specimens of healed and unhealed spondylolysis of the L5 vertebra were collected from human skeletal remains. Twelve L5 vertebrae were examples of unhealed spondylolysis and eight specimens exhibited a healed (i.e., bony fusion of the lesion) spondylolysis lesion. The specimens underwent macro and microanatomical analysis followed by CT and microCT imaging. Finally, selected healed and unhealed lesions were submitted for histological analysis using Mason Trichrome staining. The pars interarticularis of two L5 vertebrae without signs of healed/unhealed spondylolysis were evaluated histologically as controls. Of the 12 unhealed L5 pars defects, three were unilateral on left side. Of the eight healed pars defects, all were unilateral and seven of these were on left sides. One unilateral pars defect also had spina bifida occulta. Both on imaging and histological analysis, healed pars defects were only so superficially and not at deeper levels. Histologically, unhealed edges were made up of dense cortical bone while healed edges were made up primarily of trabecular bone. Based on our anatomical findings, the so‐called healed spondylolysis lesions, although externally fused, are not thoroughly fused internally. Moreover, the anterior and posterior edges of the unhealed spondylosysis lesions are irregular and show signs of long‐term disarticulation. Taken together, these data suggest that such ‘healed’ lesions might not be as stable as the normal L5 pars interarticularis.
Reconceptualizing emotion regulation and coping strategy usage in eating disorders research: The utility of a regulatory flexibility framework
Authors: Dougherty Elizabeth N. , Bottera Angeline R. , Haedt‐Matt Alissa A. , Wildes Jennifer E. 
Published: July 2023

AbstractEmotion regulation and coping strategies are often conceptualized in eating disorder (ED) research as inherently adaptive or maladaptive, and successful regulation is often defined as greater overall use of adaptive strategies. However, recent empirical work outside of the field of EDs challenges this categorical conceptualization of strategies, demonstrating that adaptiveness is determined by the ability to flexibly implement and adjust strategies based on contextual demands (i.e., regulatory flexibility). Despite evidence that emotion regulation and coping strategies are best conceptualized in terms of flexibility in the broader literature, few ED studies have adopted this model. We review the current conceptual framework of emotion regulation and coping strategies used in ED research and present regulatory flexibility as an alternative approach to conceptualizing these strategies. The lack of research on regulatory flexibility among individuals with EDs limits our understanding of the role of emotion regulation and coping difficulties in ED risk and maintenance. Adopting a regulatory flexibility model of strategies in EDs may extend knowledge of the role of emotion regulation difficulties in the development and maintenance of EDs. We highlight the potential utility of investigating regulatory flexibility and present recommendations for future research on regulatory flexibility in EDs.Public Significance StatementResearch on emotion regulation and coping strategy usage in eating disorders often view regulatory strategies as inherently adaptive or maladaptive. However, recent studies support defining strategies in terms of flexibility. Adopting a regulatory flexibility model of strategies in eating disorders research may advance knowledge of the role of emotion regulation difficulties in the development and maintenance of eating disorders, ultimately enhancing prevention and treatment efforts.
Conservation implications of a mismatch between data availability and demographic impact
Authors: Nicol‐Harper Alex , Doncaster C. Patrick , Hilton Geoff M. , Wood Kevin A. , Ezard Thomas H. G. 
Published: July 2023

AbstractCost‐effective use of limited conservation resources requires understanding which data most contribute to alleviating biodiversity declines. Interventions might reasonably prioritise life‐cycle transitions with the greatest influence on population dynamics, yet some contributing vital rates are particularly challenging to document. This risks managers making decisions without sufficient empirical coverage of the spatiotemporal variation experienced by the species. Here, we aimed to explore whether the number of studies contributing estimates for a given life‐stage transition aligns with that transition's demographic impact on population growth rate, λ. We parameterised a matrix population model using meta‐analysis of vital rates for the common eider (Somateria mollissima), an increasingly threatened yet comparatively data‐rich species of seaduck, for which some life stages are particularly problematic to study. Female common eiders exhibit intermittent breeding, with some established breeders skipping one or more years between breeding attempts. Our meta‐analysis yielded a breeding propensity of 0.72, which we incorporated into our model with a discrete and reversible ‘nonbreeder’ stage (to which surviving adults transition with a probability of 0.28). The transitions between breeding and nonbreeding states had twice the influence on λ than fertility (summed matrix‐element elasticities of 24% and 11%, respectively), whereas almost 15 times as many studies document components of fertility than breeding propensity (n = 103 and n = 7, respectively). The implications of such mismatches are complex because the motivations for feasible on‐the‐ground conservation actions may be different from what is needed to reduce uncertainty in population projections. Our workflow could form an early part of the toolkit informing future investment of finite resources, to avoid repeated disconnects between data needs and availability thwarting evidence‐led conservation.
The impact of COVID‐19 shelter‐in‐place policy responses on excess mortality
Authors: Agrawal Virat , Cantor Jonathan , Sood Neeraj , Whaley Christopher 
Published: July 2023

AbstractAs a way of slowing COVID‐19 transmission, many countries and U.S. states implemented shelter‐in‐place (SIP) policies. However, the effects of SIP policies on public health are a priori ambiguous. Using an event study approach and data from 43 countries and all U.S. states, we measure changes in excess deaths following the implementation of COVID‐19 shelter‐in‐place (SIP) policies. We do not find that countries or U.S. states that implemented SIP policies earlier had lower excess deaths. We do not observe differences in excess deaths before and after the implementation of SIP policies, even when accounting for pre‐SIP COVID‐19 death rates.