bluuebunny/crossref_metadata_2025_split huggingface dataset:
The accuracy of dynamic computer assisted implant surgery in fully edentulous jaws: A retrospective case series
Authors: Wang Jiayi , Ge Yanjun , Mühlemann Sven , Pan Shaoxia , Jung Ronald E. 
Published: August 2023

AbstractObjectivesTo evaluate the accuracy of implant placement using a dynamic navigation system in fully edentulous jaws and to analyze the influence of implant distribution on implant position accuracy.Materials and MethodsEdentulous patients who received implant placement using a dynamic navigation system were included. Four to six mini screws were placed in the edentulous jaw under local anesthesia as fiducial markers. Then patients received CBCT scans. Virtual implant positions were designed in the planning software based on CBCT data. Under local anesthesia, implants were inserted under the guidance of the dynamic navigation system. CBCTs were taken following implant placement. The deviation between the actual and planned implant positions was measured by comparing the pre‐ and postsurgery CBCT.ResultsA total of 13 edentulous patients with 13 edentulous maxillae and 7 edentulous mandibles were included, and 108 implants were placed. The average linear deviations at the implant entry point and apex were 1.08 ± 0.52 mm and 1.15 ± 0.60 mm, respectively. The average angular deviation was 2.85 ± 1.20°. No significant difference was detected in linear and angular deviations between the maxillary and mandibular implants, neither between the anterior and posterior implants.ConclusionsThe dynamic navigation system provides high accuracy for implant placement in fully edentulous jaws, while the distribution of the implants showed little impact on implant position accuracy.
Impact of new allocation system on length of stay following heart transplantation in the United States
Authors: Doulamis Ilias P. , Gemelli Marco , Rempakos Athanasios , Tzani Aspasia , Oh Nicholas A. , Kampaktsis Polydoros , Guariento Alvise , Kuno Toshiki , Alvarez Paulino , Briasoulis Alexandros 
Published: August 2023

AbstractBackgroundUnited Network for Organ Sharing (UNOS) allocation criteria changed in 2018 to accommodate the increased prevalence of ventricular assist device use as a bridge to heart transplant, which consequently prioritized sicker patients. We aimed to assess the impact of this new allocation policy on the length of stay following heart transplantation. Secondary outcomes include other risk factors for prolonged hospitalization and its effect on mortality and postoperative complications.MethodsThe UNOS Registry was queried to identify patients who underwent isolated heart transplants in the United States between 2001 and 2023. Patients were divided into quartiles according to their respective length of stay.ResultsA total of 57 020 patients were included, 15 357 of which were allocated with the new system. The median hospital length of stay was 15 days (mean 22.7 days). Length of stay was longer in the new allocation era (25 ± 30 vs. 22 ± 27 days, p < .001). The longer length of stay was associated with increased 5‐year mortality in the new allocation system (aHR: 1.18; 95% CI: 1.15, 1.20; p‐value: < .001).ConclusionLonger hospital stays and associated observed increased risk for mortality in the era after the allocation criteria change reflect the rationale of this shift which was to prioritize heart transplants for sicker patients. Further studies are needed to track the progress of surgical and perioperative management of these studies over time.
Circulating tumour DNA testing in metastatic breast cancer: Integration with tissue testing
Authors: Ranghiero Alberto , Frascarelli Chiara , Cursano Giulia , Pescia Carlo , Ivanova Mariia , Vacirca Davide , Rappa Alessandra , Taormina Sergio Vincenzo , Barberis Massimo , Fusco Nicola , Rocco Elena Guerini , Venetis Konstantinos 
Published: August 2023

AbstractBreast cancer biomarker profiling predominantly relies on tissue testing (surgical and/or biopsy samples). However, the field of liquid biopsy, particularly the analysis of circulating tumour DNA (ctDNA), has witnessed remarkable progress and continues to evolve rapidly. The incorporation of ctDNA‐based testing into clinical practice is creating new opportunities for patients with metastatic breast cancer (MBC). ctDNA offers advantages over conventional tissue analyses, as it reflects tumour heterogeneity and enables multiple serial biopsies in a minimally invasive manner. Thus, it serves as a valuable complement to standard tumour tissues and, in certain instances, may even present a potential alternative approach. In the context of MBC, ctDNA testing proves highly informative in the detection of disease progression, monitoring treatment response, assessing actionable biomarkers, and identifying mechanisms of resistance. Nevertheless, ctDNA does exhibit inherent limitations, including its generally low abundance, necessitating timely blood samplings and rigorous management of the pre‐analytical phase. The development of highly sensitive assays and robust bioinformatic tools has paved the way for reliable ctDNA analyses. The time has now come to establish how ctDNA and tissue analyses can be effectively integrated into the diagnostic workflow of MBC to provide patients with the most comprehensive and accurate profiling. In this manuscript, we comprehensively analyse the current methodologies employed in ctDNA analysis and explore the potential benefits arising from the integration of tissue and ctDNA testing for patients diagnosed with MBC.
Diabetes prevention at scale: Narrative review of findings and lessons from the DIPLOMA evaluation of the NHS Diabetes Prevention Programme in England
Authors: Bower Peter , Soiland‐Reyes Claudia , Heller Simon , Wilson Paul , Cotterill Sarah , French David , Sutton Matt 
Published: August 2023

AbstractAimsThe NHS Diabetes Prevention Programme (NHS DPP) is a large‐scale, England‐wide behaviour change programme for people at high risk of progressing to type 2 diabetes. We summarise the findings of our six‐year DIPLOMA evaluation of its implementation and impact and highlight insights for future programmes.MethodsUsing qualitative interviews, document analysis, observation, surveys and large dataset analysis, eight interlinked work packages considered: equity of access; implementation; service delivery and fidelity; programme outcomes; comparative effectiveness and cost‐effectiveness in reducing diabetes incidence; and patient decision making and experience.ResultsDelivery of the NHS DPP encountered barriers across many aspects of the programme, and we identified inequalities in terms of the areas, organisations and patient populations most likely to engage with the programme. There was some loss of fidelity at all stages from commissioning to participant understanding. Despite these challenges, there was evidence of significant reductions in diabetes incidence at individual and population levels. The programme was cost‐effective even within a short time period.ConclusionsDespite the challenge of translating research evidence into routine NHS delivery at scale, our findings suggest that an individual‐level approach to the prevention of type 2 diabetes in a ‘high‐risk’ population was more effective than usual care. By embedding evaluation with programme delivery and working closely with the NHS DPP team, we provided actionable insights for improving communications with potential participants, supporting primary care referral, honing the delivery model with better provider relationships and more patient choice, increasing understanding of behaviour change techniques, and enriching the educational and health coaching content.
Combined tricuspid atresia‐ AV septal defect—a rare congenital cardiac abnormality
Authors: Bassam Khalil , Farhat Aziz , El‐Rassi Issam , Bitar Fadi , Arabi Mariam 
Published: August 2023

AbstractIntroductionCongenital heart diseases (CHDs) are one of the most common birth defects worldwide with a prevalence of 1%. CHDs can be classified into cyanotic and acyanotic diseases based on the presence or absence of the characteristic bluish discoloration of skin and mucus membranes. A subset of cyanotic diseases is single ventricle malformations. This group of disorders comprises 1% of all CHDs. A remarkable yet rare and underreported entity of single ventricle malformations is combined tricuspid atresia (TA) and atrioventricular (AV) septal defect which is characterized by the anatomical features of both entities. Combined TA‐AV septal malformation was first anatomically described in 1953 and further explored through echocardiography and cardiac catheterization in 1987 and then 1991. Since then, no studies have been documented in the literature prompting us to share our findings.MethodsHerein we are describing a rare and underreported cardiac lesion based of a retrospective revision of medical charts at the American University of Beirut Medical Center (AUBMC) Children's Heart Center, a tertiary medical center in the Middle EastResultsOut of 200 cases with confirmed single ventricle physiology, we identified a few patients with characteristics of combined TA‐AV septal defect. Our patients exhibited characteristic echocardiographic findings of primum ASD, VSD, atretic RAVV, and clefted LAVV.ConclusionIn short, TA‐AV septal defect is a rare, underreported congenital malformation. Tracking our patients’ clinical profiles will help improve our understanding of the prognosis of this entity. Our findings may also improve treatment modalities since replacing the left‐sided valve is often overlooked if the defect is inaccurately diagnosed. In addition, such findings can help shed light on the embryological development of the rarely encountered variation of AV septal malformation.
Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS
Authors: Woods Scott W. , Parker Sophie , Kerr Melissa J. , Walsh Barbara C. , Wijtenburg S. Andrea , Prunier Nicholas , Nunez Angela R. , Buccilli Kate , Mourgues‐Codern Catalina , Brummitt Kali , Kinney Kyle S. , Trankler Carli , Szacilo Julia , Colton Beau‐Luke , Ali Munaza , Haidar Anastasia , Billah Tashrif , Huynh Kevin , Ahmed Uzair , Adery Laura L. , Marcy Patricia J. , Allott Kelly , Amminger Paul , Arango Celso , Broome Matthew R. , Cadenhead Kristin S. , Chen Eric Y. H. , Choi Jimmy , Conus Philippe , Cornblatt Barbara A. , Glenthøj Louise Birkedal , Horton Leslie E. , Kambeitz Joseph , Kapur Tina , Keshavan Matcheri S. , Koutsouleris Nikolaos , Langbein Kerstin , Lavoie Suzie , Diaz‐Caneja Covadonga Martinez , Mathalon Daniel H. , Mittal Vijay A. , Nordentoft Merete , Pasternak Ofer , Pearlson Godfrey D. , Gaspar Pablo A. , Shah Jai L. , Smesny Stefan , Stone William S. , Strauss Gregory P. , Wang Jijun , Corcoran Cheryl M. , Perkins Diana O. , Schiffman Jason , Perez Jesus , Mamah Daniel , Ellman Lauren M. , Powers Albert R. , Coleman Michael J. , Anticevic Alan , Fusar‐Poli Paolo , Kane John M. , Kahn Rene S. , McGorry Patrick D. , Bearden Carrie E. , Shenton Martha E. , Nelson Barnaby , Calkins Monica E. , Hendricks Larry , Bouix Sylvain , Addington Jean , McGlashan Thomas H. , Yung Alison R. ,   The Accelerating Medicines Partnership Schizophrenia
Published: August 2023

AbstractAimTo harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR‐P): the Structured Interview for Psychosis‐risk Syndromes (SIPS) and the Comprehensive Assessment of At‐Risk Mental States (CAARMS).MethodsThe initial workshop is described in the companion report from Addington et al. After the workshop, lead experts for each instrument continued harmonizing attenuated positive symptoms and criteria for psychosis and CHR‐P through an intensive series of joint videoconferences.ResultsFull harmonization was achieved for attenuated positive symptom ratings and psychosis criteria, and modest harmonization for CHR‐P criteria. The semi‐structured interview, named Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS (PSYCHS), generates CHR‐P criteria and severity scores for both CAARMS and SIPS.ConclusionsUsing the PSYCHS for CHR‐P ascertainment, conversion determination, and attenuated positive symptom severity rating will help in comparing findings across studies and in meta‐analyses.
Whole blood transcriptional profiling reveals highly deregulated atherosclerosis genes in Philadelphia‐chromosome negative myeloproliferative neoplasms
Authors: Skov Vibe , Thomassen Mads , Kjær Lasse , Larsen Morten Kranker , Knudsen Trine A. , Ellervik Christina , Kruse Torben A. , Hasselbalch Hans Carl 
Published: August 2023

AbstractBackgroundThe Philadelphia‐negative chronic myeloproliferative neoplasms (MPNs) are associated with a huge comorbidity burden, including an increased risk of cardiovascular diseases. Recently, chronic inflammation has been suggested to be the driving force for clonal evolution and disease progression in MPN but also potentially having an impact upon the development of accelerated (premature) atherosclerosis.ObjectivesSince chronic inflammation, atherosclerosis, and atherothrombosis are prevalent in MPNs and we have previously shown oxidative stress genes to be markedly upregulated in MPNs, we hypothesized that genes linked to development of atherosclerosis might be highly deregulated as well.MethodsUsing whole blood gene expression profiling in patients with essential thrombocythemia (ET; n = 19), polycythemia vera (PV; n = 41), or primary myelofibrosis (PMF; n = 9), we herein for the first time report aberrant expression of several atherosclerosis genes.ResultsOf 84 atherosclerosis genes, 45, 56, and 46 genes were deregulated in patients with ET, PV, or PMF, respectively. Furthermore, BCL2L1, MMP1, PDGFA, PTGS1, and THBS4 were progressively significantly upregulated and BCL2 progressively significantly downregulated from ET over PV to PMF (all FDR <0.05).ConclusionsWe have for the first time shown massive deregulation of atherosclerosis genes in MPNs, likely reflecting the inflammatory state in MPNs in association with in vivo activation of leukocytes, platelets, and endothelial cells being deeply involved in the atherosclerotic process.
Real‐world practice of Helicobacter pylori management: A survey among physicians in Southeast Asia
Authors: Quach Duc Trong , Vilaichone Ratha‐korn , Luu Mai Ngoc , Lee Yeong Yeh , Ang Tiing Leong , Miftahussurur Muhammad , Aye Than Than , Basir Dewi Norwani , Vutha Ky , Vannarath Sengdao , Sollano Jose D. , Mahachai Varocha 
Published: August 2023

AbstractBackgroundMultidrug‐resistant Helicobacter pylori strains are emerging in Southeast Asia. This study evaluates the region's real‐world practice in H. pylori management.Materials and MethodsPhysicians who managed H. pylori eradication in daily practice across 10 Southeast Asian countries were invited to participate in an online questionnaire, which included questions about the local availability of antimicrobial susceptibility tests (ASTs) and their preferred eradication regimens in real‐world practice. An empiric regimen was considered inappropriate if it did not follow the local guidelines/consensus, particularly if it contained antibiotics with a high reported resistance rate or was recommended not to be empirically used worldwide.ResultsThere were 564 valid responses, including 314 (55.7%) from gastroenterologists (GIs) and 250 (44.3%) from non‐GI physicians. ASTs were unavailable in 41.7%. In countries with low and intermediate clarithromycin resistance, the most common first‐line regimen was PAC (proton pump inhibitor [PPI], amoxicillin, clarithromycin) (72.7% and 73.2%, respectively). Regarding second‐line therapy, the most common regimen was bismuth‐based quadruple therapy, PBMT (PPI, bismuth, metronidazole, tetracycline) (50.0% and 59.8%, respectively), if other regimens were used as first‐line treatment. Concomitant therapy (PPI, amoxicillin, clarithromycin, metronidazole) (30.5% and 25.9%, respectively) and PAL (PPI, amoxicillin, levofloxacin) (22.7% and 27.7%, respectively) were favored if PBMT had been used as first‐line treatment. In countries with high clarithromycin resistance, the most common first‐line regimen was PBMT, but the utilization rate was only 57.7%. Alarmingly, PAC was prescribed in 27.8% of patients, ranking as the second most common regimen, and its prescription rate was higher in non‐GI physicians than GI physicians (40.1% vs. 16.2%, p < 0.001).ConclusionsChoosing inappropriate regimens containing antibiotics with high resistance rates is not uncommon in Southeast Asia, especially among non‐GI physicians. In countries with high clarithromycin resistance, the PBMT regimen is underutilized.
Ceftazidime reduces cellular Skp2 to promote type‐I interferon activity
Authors: Qiao Caixia , Huang Fan , He Jiuyi , Wu Qiuyu , Zheng Zhijin , Zhang Tingting , Miao Ying , Yuan Yukang , Chen Xiangjie , Du Qian , Xu Yang , Wu Depei , Yu Zhengyuan , Zheng Hui 
Published: August 2023

AbstractSkp2 plays multiple roles in malignant tumours. Here, we revealed that Skp2 negatively regulates type‐I interferon (IFN‐I)‐mediated antiviral activity. We first noticed that Skp2 can promote virus infection in cells. Further studies demonstrated that Skp2 interacts with IFN‐I receptor 2 (IFNAR2) and promotes K48‐linked polyubiquitination of IFNAR2, which accelerates the degradation of IFNAR2 proteins. Skp2‐mediated downregulation of IFNAR2 levels inhibits IFN‐I signalling and IFN‐I‐induced antiviral activity. In addition, we uncovered for the first time that the antibiotic ceftazidime can act as a repressor of Skp2. Ceftazidime reduces cellular Skp2 levels, thus enhancing IFNAR2 stability and IFN‐I antiviral activity. This study reveals a new role of Skp2 in regulating IFN‐I signalling and IFN‐I antiviral activity and reports the antibiotic ceftazidime as a potential repressor of Skp2.
Improved densification in cold sintering of gadolinia‐doped ceria with reactive sintering aids
Authors: Zhao Yuye , Tang Jian , Xu Hongliang , Zhu Lei , Ni Na 
Published: August 2023

AbstractThis study explores a novel reactive cold sintering method for improving the density of gadolinia‐doped ceria (GDC) ceramics while reducing the annealing temperature. Instead of using deionized water as an aid in conventional cold sintering, stoichiometrically mixed Ce(NO3)3·6H2O and Gd(NO3)3·6H2O precursors were added as additives during the CSP in this study. The effects of processing parameters such as sintering temperature and additive content on the relative density of the compacts were investigated using synthesized GDC and commercial GDC powders as raw materials. The results showed that with the aid of precursors, GDC ceramics were sintered up to 90% of their theoretical densities at 850°C and up to 94% at 950°C when the synthesized nanopowder GDC was used. Additionally, the sintering mechanism was investigated, and it was found that the GDC generated by the precursor reaction effectively filled the gaps between the original particles, promoting densification of the sample after cold‐pressing.
Preparation of granite powder–based geopolymer by synergistic action of calcination and phosphoric acid
Authors: Jia Luxia , Huang Min , Huang Muyang , Luo Yongpeng , Zhang Xiuze , Liao Xianqing , Bao Shenxu 
Published: August 2023

AbstractUsing the solid waste of granite powder (GP) to prepare green cementitious materials is of great significance for the sustainable development of the construction industry. In this study, a phosphoric acid–based geopolymer (PABG) was directly prepared from GP through a combination of phosphoric acid and calcination processes. Reaction mechanism of phosphoric‐activated GP is studied by techniques of X‐ray diffraction, thermal analysis, Fourier transform infrared spectroscopy, SE mode, and mercury intrusion porosimetry (MIP) taking calcination temperature, calcination time, and phosphoric acid as variables. The results indicated that the addition of 15 wt.% phosphoric acid and calcination at the temperature of 200°C for 90 min significantly increased compressive strength from 0.70 to 20.92 MPa. The calcination temperature was the most important factor in the synthesis of PABG using GP. The decrease of the peak value of mineral phase after calcination indicates that high temperature promotes the reaction between phosphoric acid and GP. According to the results of MIP, the gel generated by the reaction of phosphoric acid and GP refines the pore structure, which is conducive to the improvement of geopolymer properties. These research results provide a reference for the preparation of geopolymers directly using low pozzolanic active GP.
Hidradenitis suppurativa: Detangling phenotypes and identifying common denominators
Authors: Vișan Maria‐Alexandra , Căruntu Constantin , Costache Raluca Simona , Tiplica George , Costache Daniel Octavian 
Published: August 2023

AbstractHidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a severe impact on patients' quality of life through its recurrent and painful nature, as well as its comorbidity burden. The shift in the pathogenic paradigm from a condition of the apocrine glands to an autoinflammatory disease associated with follicular destruction has rendered its understanding difficult, as there are still large gaps in pinpointing the underlying mechanisms, which cannot currently explain the existing clinical variation and as a result, translate into suboptimal therapy. Multifactorial involvement is hypothesized, with an implication of genetic mutations, microbiome dysbiosis, cytokine upregulation and environmental factors. Clinical observation is fundamental for diagnosis, however, the marked heterogeneity in presentation leads to delays in detection and challenges in treatment selection, showcasing clear limits in defining the link between genetic aspects of HS, the role of epigenetic factors and its pathogenic pathways. There have been attempts to formulate phenotypes that could aid in prognostication and management, however, current classification schemata show significant overlap and no validation through longitudinal studies. In this context, nomenclature poses a great challenge due to the lack of global agreement in the definition of lesions, which should be addressed by future research to enable simplified recognition and allow for more precise severity scoring. This could be complemented by the addition of extra dermatologic findings or paraclinical assessment in constructing phenotypes. The development of valid, predictive and reliable classifications of HS may lead to an improvement in comprehending its pathophysiology, favouring a more personalized approach in management. This could be achieved through consensus in the characterization of clinical features and data gathering, as well as validation attempts for described phenotypes. Ultimately, the genotype‐endotype‐phenotype correlation in HS requires targeted, systematic inquiries and should be addressed more largely to broaden the perspective on this debilitating entity.