bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunoglobulin G4 in eosinophilic esophagitis: Immune complex formation and correlation with disease activity
Authors: Medernach Jonathan G. , Li Rung‐Chi , Zhao Xiao‐Yu , Yin Bocheng , Noonan Emily A. , Etter Elaine F. , Raghavan Shyam S. , Borish Larry C. , Wilson Jeffrey M. , Barnes Barrett H. , Platts‐Mills Thomas A. E. , Ewald Sarah E. , Sauer Bryan G. , McGowan Emily C. 
Published: July 2023

AbstractBackgroundRecent studies have shown deposition of immunoglobulin G4 (IgG4) and food proteins in the esophageal mucosa of eosinophilic esophagitis (EoE) patients. Our aims were to assess whether co‐localization of IgG4 and major cow's milk proteins (CMPs) was associated with EoE disease activity and to investigate the proteins enriched in proximity to IgG4 deposits.MethodsThis study included adult subjects with EoE (n = 13) and non‐EoE controls (n = 5). Esophageal biopsies were immunofluorescence stained for IgG4 and CMPs. Co‐localization in paired samples from active disease and remission was assessed and compared to controls. The proteome surrounding IgG4 deposits was evaluated by the novel technique, AutoSTOMP. IgG4‐food protein interactions were confirmed with co‐immunoprecipitation and mass spectrometry.ResultsIgG4‐CMP co‐localization was higher in the active EoE group compared to paired remission samples (Bos d 4, p = .02; Bos d 5, p = .002; Bos d 8, p = .002). Co‐localization was also significantly higher in the active EoE group compared to non‐EoE controls (Bos d 4, p = .0013; Bos d 5, p = .0007; Bos d 8, p = .0013). AutoSTOMP identified eosinophil‐derived proteins (PRG 2 and 3, EPX, RNASE3) and calpain‐14 in IgG4‐enriched areas. Co‐immunoprecipitation and mass spectrometry confirmed IgG4 binding to multiple food allergens.ConclusionThese findings further contribute to the understanding of the interaction of IgG4 with food antigens as it relates to EoE disease activity. These data strongly suggest the immune complex formation of IgG4 and major cow's milk proteins. These immune complexes may have a potential role in the pathophysiology of EoE by contributing to eosinophil activation and disease progression.
Complementary feeding practices are related to the risk of food allergy in the ELFE cohort
Authors: Adam T. , Divaret‐Chauveau A. , Roduit C. , Adel‐Patient K. , Deschildre A. , Raherison C. , Charles M.‐A. , Nicklaus S. , de Lauzon‐Guillain B. 
Published: July 2023

AbstractBackgroundConflicting results have been obtained when analyzing the relationship between complementary feeding (CF) practices and allergic diseases in childhood. This study aims to further explore the association between allergic diseases in early childhood (10.1016/j.jaci.2012.02.036) and the age at CF introduction (10.1016/S0140‐6736(15)00149‐X), food diversity in the first year of life (10.1016/j.ijporl.2019.109759) and the delayed introduction of major allergenic foods.MethodsThis analysis focused on 6662 children from the French nationwide ELFE cohort. Data on feeding practices were collected monthly from 3 to 10 months old. Their age at CF introduction was calculated alongside a diversity score, and the number of major allergenic foods (out of eggs, fish, wheat, and dairy products) not introduced at 8 and 10 months. Their associations with parent‐reported allergy‐related health events between 1 and 5.5 years were assessed using logistic regressions adjusted for confounding factors. A sensitivity analysis excluding early allergic cases (occurring between 2 months and 1 or 2 years) was conducted.ResultsLate CF (>6 months) was related to a higher risk of food allergy (OR [95% CI] = 1.35 [1.02; 1.78]), a low diversity score at 8 months to a higher risk of asthma (OR [95% CI] = 1.22 [1.01; 1.48]), and two allergenic foods or more not being introduced at 10 months to a higher risk of rhinoconjunctivitis (OR [95% CI] = 1.20 [1.00; 1.44]) and food allergy (OR [95% CI] = 2.46 [1.77; 3.42]). Only this last association remained significant after the exclusion of early cases.ConclusionThe delayed introduction of major allergenic foods is related to a higher risk of food allergy, which supports the updated guidelines for allergy prevention.
Functioning in older adults with bipolar disorder: A report on recommendations by the International Society of bipolar disorder (ISBD) older adults with bipolar disorder (OABD) task force
Authors: Montejo Laura , Orhan Melis , Chen Peijun , Eyler Lisa T. , Gildengers Ariel , Martinez‐Aran Anabel , Nunes Paula Villela , Olagunju Andrew T. , Patrick Regan , Vieta Eduard , Dols Annemiek , Jimenez Esther 
Published: July 2023

AbstractObjectivesDespite the importance of psychosocial functioning impairment in Bipolar Disorder (BD), its role among Older Adults with BD (OABD) is not well known. The development of guidelines for the assessment of psychosocial functioning helps to facilitate a better understanding of OABD and can lead to better tailored interventions to improve the clinical outcomes of this population.MethodsThrough a series of virtual meetings, experts from eight countries in the International Society of Bipolar Disorder (ISBD) on OABD task force developed recommendations for the assessment of psychosocial functioning.ResultsWe present (1) a conceptualization of functioning in OABD and differences compared with younger patients; (2) factors related to functioning in OABD; (3) current measures of functioning in OABD and their strengths and limitations; and, (4) other potential sources of information to assess functioning.ConclusionsThe task force created recommendations for assessing functioning in OABD. Current instruments are limited, so measures specifically designed for OABD, such as the validated FAST‐O scale, should be more widely adopted. Following the proposed recommendations for assessment can improve research and clinical care in OABD and potentially lead to better treatment outcomes.
Smart access and smart protection for welfare gain in Europe during COVID‐19: An empirical investigation using real‐time data
Authors: Pasha Humaira Kamal 
Published: July 2023

AbstractThe COVID‐19 (Coronoavirus Disease 2019) pandemic has had many disastrous effects on welfare globally, particularly in European countries. In recent research, a new debate has arisen as a result of the shift of day‐to‐day activities to virtual platforms, which has augmented concerns related to smart (data) access and smart (data) protection. This study examines the economic, social, and psychological indicators of welfare gain within the context of the COVID‐19 pandemic and examines their impact on smart access and smart protection using the data of Survey of Health, Ageing and Retirement in Europe and real‐time Google Trends from June to August 2020. The findings indicate a negative relationship between smart access and economic crisis caused by COVID‐19, while households with sufficient resources support smart protection. Psychological effects including nervousness and anxiety are highly related to smart access. Likewise, being helpful in a time of uncertainty, societal contact, and social measures (hygiene and face mask) significantly and positively impact smart protection. The findings suggest that countries should combine their welfare agencies with health and economic institutes, and initiate projects related to cybersecurity.
Lysyl oxidase‐like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3
Authors: Lu Yi‐Jie , Deng Yi‐Ting , Ko Hui‐Hsin , Peng Hsin‐Hui , Lee Hsiang‐Chieh , Kuo Mark Yen‐Ping , Cheng Shih‐Jung 
Published: July 2023

AbstractLysyl oxidase‐like 2 (LOXL2) is a matrix‐remodeling enzyme that has recently been identified as an important regulator of tumor progression and metastasis. This study discovered that LOXL2 expression in oral squamous cell carcinoma (OSCC) tissues was significantly associated with tumor clinical stage, lymph node metastasis and patients' overall survival time. LOXL2‐overexpressing human buccal SCC TW2.6 (TW2.6/LOXL2) and hypopharyngeal SCC FaDu (FaDu/LOXL2) cells exhibited enhanced migration, invasion, epithelial–mesenchymal transition (EMT), and cancer stem cell (CSC) phenotypes, independently of its enzymatic activity. Moreover, TW2.6/LOXL2 significantly increased tumor‐initiating frequency in SCID mice. We further demonstrated that LOXL2 increased the levels of interferon‐induced protein with tetratricopeptide repeats 1 (IFIT1) and IFIT3 in TW2.6/LOXL2 and FaDu/LOXL2 cells. We also identified IFIT1 and IFIT3 as key downstream components of LOXL2 action in migration, invasion, EMT, and CSC phenotypes in TW2.6 and FaDu cells. Furthermore, a significant positive correlation between LOXL2 expression and IFIT1 and IFIT3 overexpression in human OSCC tissues was observed. In addition, TW2.6/LOXL2 and FaDu/LOXL2 cells were 3.3‐ to 3.6‐fold more susceptible to the epidermal growth factor receptor (EGFR) inhibitor gefitinib than were their respective control cells. The antitumor effect of gefitinib on orthotopic TW2.6/LOXL2 xenograft tumor was fourfold higher than that on controls. Our results indicate that LOXL2 expression is a strong prognostic factor for OSCC and may be used as a marker to identify patients most likely to respond to EGFR‐targeted therapy.
Role of the functional head impulse test in evaluating vestibulo‐ocular reflex abnormalities in individuals with Parkinson's disease
Authors: Karababa Ercan , Sonkaya Ali Rıza , Satar Bülent , Korkmaz Hanifi 
Published: July 2023

AbstractPurposeTo assess vestibular‐ocular reflex (VOR) function in patients with Parkinson's disease (PD) using a new method called functional head impulse test (fHIT).Study DesignCase–control study.SettingTertiary medical center.ParticipantsTwenty individuals with PD were recruited for PD group, and twenty healthy individuals for the control group. Ages of both groups ranged from 47 to 76 years.Main Outcome MeasuresAccording to the modified Hoehn‐Yahr score, PD group was classified as an early stage with a range of 1–2.5 and a mid‐late stage with a range of 3–5. Percentage of correct answers (%CA) was calculated using fHIT for lateral, anterior and posterior semicircular canal (SCC) planes.ResultsPD group had statistically lower fHIT %CA in the right lateral, left lateral, and left posterior SCC planes compared to control group (p < .05). There was no statistical difference between two PD severity groups and functional VOR abnormality.ConclusionIt was concluded that the functional VOR in the right lateral and left lateral and left posterior SCC plane was affected in individuals with PD. Our results show that impaired VOR and reduced dynamic visual acuity should be considered in individuals with PD for vestibular rehabilitation exercises.
Keratin‐positive giant cell‐rich tumors of soft tissue with HMGA2::NCOR2 fusions
Authors: Weigelt Maximillian A. , Azzato Elizabeth M. , Habermehl Gabriel K. , Billings Steven D. , Ko Jennifer S. , Fritchie Karen J. 
Published: July 2023

AbstractBackgroundGiant cell tumor of soft tissue (GCT‐ST) is a rare soft tissue neoplasm that is morphologically similar to but genetically distinct from giant cell tumor of bone. A novel keratin‐positive GCT‐ST (KPGCT‐ST) harboring HMGA2::NCOR2 fusions was recently discovered. Fewer than 30 cases have been described; herein is reported an additional seven.MethodsCases diagnosed as GCT‐ST were retrieved from institutional archives and consultation files. The histopathologic characteristics were assessed, and the electronic medical record was reviewed.ResultsSeven tumors were identified in six women and one man with a median age of 23 years. All patients underwent excision; no recurrences or metastases were noted during a median follow‐up period of 7 months. Histopathologically, the tumors were characterized by a multinodular proliferation of keratin‐positive mononuclear cells with evenly admixed osteoclast‐like giant cells and absent neoplastic bone. A fibrous capsule with lymphoid cuffing was frequently seen. Foamy macrophages, inflammation, hemorrhage, and hemosiderin were variably present. The HMGA2::NCOR2 fusion was detected in all cases.ConclusionsOur findings support previously reported hypotheses that KPGCT‐ST is a spectrum of the same entity as the recently described xanthogranulomatous epithelial tumor. Although follow‐up data are limited, to date, KPGCT‐ST appears to follow an indolent course.
Caveolin‐1 protein expression as a prognostic biomarker of gastrointestinal tumours: A systematic review and meta‐analysis
Authors: Kamposioras Konstantinos , Dinas Petros C. , Barriuoso Jorge , Trachana Varvara , Dimas Konstantinos 
Published: July 2023

AbstractBackgroundGastrointestinal (GI) cancers remain a major threat worldwide, accounting for over 30% of cancer deaths. The identification of novel prognostic biomarkers remains a challenge despite significant advances in the field. The CAV1 gene, encoding the caveolin‐1 protein, remains enigmatic in cancer and carcinogenesis, as it has been proposed to act as both a tumour promoter and a tumour suppressor.MethodsTo analyse the differential role of caveolin‐1 expression in both tumour cells and stroma in relation to prognosis in GI tumours, we performed a systematic review and meta‐analysis according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines; PROSPERO registration number: CRD42022299148.ResultsOur analysis showed that high levels of caveolin‐1 in tumour cells were associated with poor prognosis and inferior overall survival (OS) in oesophageal and pancreatic cancer and hepatocellular carcinoma (HCC), but not in gastric and colorectal cancer. Importantly, our study showed that higher stromal caveolin‐1 expression was associated with significantly longer OS and disease‐free survival in colorectal cancer. Analysis of stromal caveolin‐1 expression in the remaining tumours showed a similar trend, although it did not reach statistical significance.ConclusionsThe data suggest that caveolin‐1 expression in the tumour cells of oesophageal, pancreatic cancer and HCC and in the stroma of colorectal cancer may be an important novel predictive biomarker for the clinical management of these diseases in a curative setting. However, the main conclusion of our analysis is that caveolin‐1 expression should always be assessed separately in stroma and tumour cells.
A comparison of neutral‐action and interaction‐independent integrals for mixed‐mode problems
Authors: González‐Albuixech Vicente F. , Giner Eugenio 
Published: July 2023

AbstractThe fracture of structures under mixed‐mode loaded cracks is usually assessed using stress intensity factors (SIFs). Domain integrals, specially the
‐integral and the interaction integral, are widely used for SIF extraction and provide high accurate estimations with finite element methods, although the
‐integral does not allow the separation of the SIF components. However, interaction integral definition implies hypothesis that are not fulfilled in generic non‐planar cracks and therefore other methods can be an option to solve this problem. A different path‐independent integral, the neutral‐action integral, was introduced in 2010 by Kienzler et al. The application of the
‐integral and the neutral‐action integral allows the computation of the SIF in a mixed‐mode situation and separate the SIF components. The presented study considers the applicability of the neutral‐action integral and investigates its limitations. The research is performed using well‐known and basic problems that can be considered as a basis for other more complicated cases, in order to obtain an convergence analysis without introducing further errors.
Unveiling the rise of non‐native fishes in eastern alpine mountain rivers: Population trends and implications
Authors: Niedrist G. H. , Hilpold A. , Kranebitter P. 
Published: July 2023

AbstractInsufficient knowledge about the occurrence and spread of non‐native fish in mountain regions has impeded effective management strategies worldwide. To address this gap, this study analysed over 1300 electrofishing surveys across 650 sites, encompassing a vast 7400 km2 area in the Eastern Alps. The primary objectives were to quantify the occurrence of non‐native species and predict their spread in different river types. Furthermore, the study estimated population sizes and biomass trends for over 150 sites that were surveyed multiple times between 2000 and 2020. Out of the 42 fish species in the study region, 11 were identified as non‐native. Notably, two invasive species of Union concern, Lepomis gibbosus and Pseudorasbora parva, increased their population sizes by 8% and 9% per year, over the past decades, supposedly supported by increasing water temperatures. Among the non‐native species relevant for recreational fishing, Oncorhynchus mykiss populations showed a significant increase of approximately 7% per year, Salmo trutta populations remained stable, and Salvelinus fontinalis populations experienced a notable decline of approximately 7.4% per year. These varying population trends may be attributed to disparities in stocking intensities, with S. fontinalis receiving minimal stocking compared to the other species. This study revealed that non‐native and invasive fish species are a relevant part of fish communities in mountain rivers. Non‐salmonid non‐natives thrive in warm rivers at lower elevations, whereas salmonid non‐natives consolidate in steeper habitats. Because rising temperatures in mountain rivers will accelerate the spread and growth of these species, this first quantification of the current extent will improve fish management strategies in mountainous areas.
Clinical and histological features of patients with chronic hepatitis B virus infection in the grey zone
Authors: Gan Qin Yi , Wang Jie Xiao , Qian Feng , Wang Yin Ling , Huang Yan , Zhang Zheng Lan , Jiang Shao Wen , Zhang Chen Xi , Cai Ming Hao , Qian Cong , Fu Hao Shuang , Zhao Shuang , Zhou Hui Juan , Cao Zhu Jun , Xie Qing 
Published: July 2023

AbstractChronic HBV infection patients who do not conform to any of the usual immune states are regarded as ‘grey zone’ patients. We aimed to investigate the proportion of chronic HBV infection patients in the grey zone, and evaluate the clinical characteristics and liver pathological changes in grey zone patients. Clinical data of 1391 treatment‐naive chronic HBV infection patients with liver biopsy were collected. Natural history of HBV infection was determined based on European Association for the Study of the Liver (EASL) 2017, American Association for the Study of Liver Diseases (AASLD) 2018 and Chinese 2019 guidelines for the prevention and treatment of chronic HBV infection. Significant liver histological changes and associated risk factors of normal ALT grey zone patients were analysed. According to EASL, AASLD and Chinese criteria, there were 50.0%, 28% and 37.4% chronic HBV infection patients in the grey zone. Among the 353 grey zone patients with normal ALT, 72.4% had significant liver histological changes. ALT (optimal cut‐off value 25 IU/L) and HBV DNA (optimal cut‐off value 18,000 IU/mL) were independent risk factors of significant liver histological abnormalities. In conclusion, a substantial proportion of grey zone patients with normal ALT have significant liver histological changes that can be predicted by levels of serum ALT and HBV DNA. These results provide guidance of antiviral treatment in grey zone patients.
Serum 25‐hydroxyvitamin D, vitamin D receptor, and vitamin D binding protein concentrations in dogs with acute pancreatitis compared to healthy control dogs
Authors: Lee Dohee , Koo Yoonhoi , Chae Yeon , Choi Yeongeun , Yun Taesik , Kang Byeong‐Teck , Yang Mhan‐Pyo , Kim Hakhyun 
Published: July 2023

AbstractBackgroundPrevious studies have documented vitamin D imbalance in dogs with acute pancreatitis (AP), but no studies have investigated serum vitamin D receptor (VDR) and vitamin D‐binding protein (VDBP) concentrations.ObjectivesCompare serum 25‐hydroxyvitamin D (25[OH]D), VDR, and VDBP concentrations in healthy dogs and dogs with AP and identify correlations between these concentrations with ionized calcium, C‐reactive protein (CRP), and canine‐specific pancreatic lipase (Spec cPL) concentrations.AnimalsTwenty‐two dogs with AP and 20 healthy control dogs.MethodsProspective cross‐sectional study. Serum 25(OH)D concentrations were measured using a chemiluminescence immunoassay, and VDR and VDBP concentrations were measured using a ELISA kit designed for dogs.ResultsSerum concentrations of 25(OH)D were lower in dogs with AP (mean ± SD, 66.1 ± 39.2 ng/mL) than in controls (96.8 ± 30.4 ng/mL;P = .01), and VDR concentrations were lower in dogs with AP (5.3 ± 3.5 ng/mL) than in controls (7.4 ± 2.5 ng/mL;P = .03). No difference was observed in serum VDBP concentrations between the groups. Serum VDR concentrations differed between survivors (median [interquartile range] = 6.6 [4.3‐8.2] ng/mL) and nonsurvivors (2.7 [0.5‐3.5] ng/mL;P = .01). Negative correlations were observed among serum VDR, CRP (rs = −0.55), and Spec cPL (rs = −0.47) concentrations in dogs with AP.Conclusions and Clinical ImportanceDogs with AP had lower serum 25(OH)D and VDR concentrations than controls. Additionally, our study suggests a potential role of VDR expression in the inflammatory process of AP in dogs.
Impact of anesthetics on pyloric characteristics measured using the EndoFLIP® system in patients with gastroparesis
Authors: Desprez Charlotte , Jacques Jérémie , Clavier Thomas , Wallenhorst Timothée , Leroi Anne Marie , Gourcerol Guillaume 
Published: July 2023

AbstractBackgroundPyloric distensibility has been reported as a predictive measure in gastroparesis. Measures can be obtained either during endoscopy under anesthesia or in unsedated patients. However, the impact of anesthetic drugs on the results of pyloric characteristics remains unknown. The objective of the present study was to determine the impact of anesthetics on pyloric characteristics measured using EndoFLIP® in patients with gastroparesis.MethodsConsecutive patients with gastroparesis from three French tertiary centers were retrospectively analyzed. Patients with a previous history of pyloric intervention were not considered for analysis. Medical records were reviewed for the potential use of anesthetic drugs during EndoFLIP® measurement.Key ResultsOne hundred twenty‐five patients were included in the present study [median age: 55.0 years (43.0–66.0)]. Thirty‐four patients (27.2%) had pyloric assessment without general anesthesia and 91 patients (72.8%) with general anesthesia. Pyloric pressure at 40 mL of distension was higher in patients with general anesthesia in comparison with patients without general anesthesia [18.7 (13.0–25.6) mmHg vs. 15.4 (11.9–20.7) mmHg; p = 0.044)]. In multivariate analysis, suxamethonium chloride administration was associated with decreased pyloric distensibility (OR: 3.9; 95% CI: 1.3–11.4; p = 0.013) while ephedrine was rather associated with increased pyloric distensibility (OR: 0.3; 95% CI: 0.1–0.9; p = 0.036).Conclusions and InferencesThis study is the first to have found an impact of general anesthesia on pyloric measurement using the EndoFLIP®. Therefore, further studies are needed to confirm these findings, if possible, prospective studies.