bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban distance to mental healthcare units and public transport increases duration of untreated psychosis in first-episode patients
Authors: Malinowski Fernando , Noto Cristiano , Cavalcante Daniel , Belangero Síntia , Ziebold Carolina , Bressan Rodrigo , Gadelha Ary 
Published: June 2023

Background: There is a growing interest in environmental and social determinants of mental health. However, how distance to healthcare and public transportation affect illness is neglected in schizophrenia research. Here, we are interested in how the availability of mental healthcare and the ways to reach it may be associated with psychosis. Aims: We aim to investigate the association between distances to healthcare units and subway stations and duration of untreated psychosis (DUP) and greater initial severity in an antipsychotic-naïve first episode of psychosis (FEP) sample. Method: Using 212 untreated FEP patients’ data, we calculated the distances from their residences to the places of interest. Diagnoses comprehended schizophrenia spectrum disorders, depressive and bipolar affective disorders, and substance-induced disorders. Linear regressions were performed with distances as independent variables, DUP and Positive and Negative Syndrome Scale (PANSS) scores as dependent variables. Results: Longer distance to emergency mental healthcare was related to longer DUP (95% CI: p = .034, B = 0.152) and higher total PANSS (95% CI: p = .007, B = 0.0189); longer distance to community mental healthcare units was related to longer DUP (95% CI: p = .004, B = 0.0204) and higher total PANSS (95% CI: p = .030, B = 0.152). Moreover, a longer distance to the closest subway station predicted longer DUP (95% CI: p = .019, B = 0.170). Conclusion: Our results indicate that poor healthcare access is related to longer DUP and higher initial PANSS scores. Future research should investigate how investments in mental health access and actions to improve public transport access could impact DUP and treatment outcomes in psychosis patients.
Thermochemical recycling of epoxy resin composites reinforced with carbon fiber
Authors: Nicolai Gabriel , Bôas Augusto PV , Méndez Manoel OA , Taranto Osvaldir P 
Published: June 2023

The aim of this study was to recovery carbon fiber present in composite materials with epoxy resin matrix using a thermochemical recycling way. A full factorial design was proposed with two factors: the degradation temperature (DT) and the number of thermal baths (NB), which were evaluated in a range of 600°C–650°C and 0–2 baths, respectively, for 30 min. The responses were burn-off degree (BO) and tensile strength. The BO indicated that the temperature as well as the number of thermal baths have positive effects and, therefore, contribute to the degradation of the epoxy resin. Regarding the tensile strength, higher DT promotes a more pronounced effect in that response, but its interaction with NB causes greater damage to the surface of the carbon fiber. A new recycling condition was evaluated and compared with commercial carbon fiber. The results of tensile strength indicated it is possible to test similar applications for both recovered fiber and commercial fiber. The morphological characterizations showed that recycled materials preserved their physical structure, and all surface groups were removed throughout the thermochemical degradation process. In addition, the SEM analyzes indicated the preservation of the wefts after recycling, although residual matrix and the beginning of sizing destruction were observed. Thermochemical recycling proved to be an effective and better way to reuse carbon fiber instead of landfill and incineration.
Samba and Surveillance: Censorship and Black Music during Brazilian Military Rule, 1964–1985
Authors: Bocskay Stephen 
Published: June 2023

The censorship and surveillance practices imposed on samba schools, musical performances, and compositions in Rio de Janeiro during the period of the military dictatorship (1964–1985) targeted black political organization at large and musical perspectives on black history and culture. Interviews with samba musicians and analyses of political police documents underscore the military government’s control of discourses and suppression of archives, demonstrating that censorship and surveillance in music and the arts continued after 1985. As práticas de censura e vigilância impostas às escolas de samba, performances e composições musicais no Rio de Janeiro durante o período da ditadura militar (1964-1985) cercearam a organização política negra em geral e as perspectivas musicais sobre a história e a cultura negras. Entrevistas com sambistas e análises de documentos policiais ilustram o controle governamental de discursos e o apagamento de arquivos, demonstrando que a censura e a vigilância na música e nas artes continuaram após 1985.
‘That just doesn’t feel right at times’ – lone working practices, support and educational needs of newly employed Healthcare Assistants providing 24/7 palliative care in the community: A qualitative interview study
Authors: Patynowska Katarzyna A , McConnell Tracey , McAtamney Colette , Hasson Felicity 
Published: June 2023

Background: Healthcare assistants working in hospice at home settings have a pivotal role in supporting people dying at home and their family caregivers. Some healthcare assistants are working alone in patients’ homes, which magnifies some of the issues reported for those working closely with other team members. There is a dearth of evidence in terms of education, training and support needs for healthcare assistants when working alone. Aim: To explore the role of newly employed lone working healthcare assistants delivering palliative care in the community, and their support and educational needs. Design: Qualitative exploratory study using semi-structured interviews. Setting/participants: Healthcare assistants ( n = 16) employed less than 12 months by a national non-profit hospice and palliative care provider located across the UK. Results: Analysis of interviews identified three main themes: (1) Healthcare assistants have a unique and complex role catering for holistic needs of patients and their family caregivers in the home environment; (2) preparation for the complex role requires focus on experiential learning and specific training to support holistic care provision; (3) lone workers experience loneliness and isolation and identify peer support as a key intervention to support their wellbeing. Conclusions: Given the complexities of their role within community palliative care teams, there are key learning points in relation to healthcare assistant preparation. Education and support networks should be prioritised to reduce isolation and support ongoing learning and development of newly employed healthcare assistants; all of which is vital to ensure safety and quality of care for the growing number of people they support in the community.
Baseline cognitive function predicts full remission of suicidal symptoms among patients with treatment-resistant depression and strong suicidal ideation after low-dose ketamine infusion
Authors: Lin Wei-Chen , Su Tung-Ping , Li Cheng-Ta , Wu Hui-Ju , Tsai Shih-Jen , Bai Ya-Mei , Tu Pei-Chi , Chen Mu-Hong 
Published: June 2023

Background: Whether pretreatment working memory and response inhibition function are associated with the rapid and sustained antisuicidal effect of low-dose ketamine among patients with treatment-resistant depression (TRD) and strong suicidal ideation is unclear. Methods: We enrolled 65 patients with TRD, comprising 33 who received a single infusion of 0.5 mg/kg ketamine and 32 who received a placebo infusion. The participants performed working memory and go/no-go tasks prior to infusion. We assessed suicidal symptoms at baseline and on postinfusion Days 2, 3, 5, and 7. Results: The full remission of suicidal symptoms persisted for 3 days after a single ketamine infusion and the ketamine-related antisuicidal effect persisted for 1 week. Lower cognitive impairment at baseline (indicated by a higher rate of correct responses on a working memory task) was associated with the rapid and sustained antisuicidal effect of low-dose ketamine in patients with TRD and strong suicidal ideation. Discussion: Patients with TRD and strong suicidal ideation but low cognitive impairment may benefit the most from the antisuicidal effect of low-dose ketamine.
Should we touch tricuspid valve at the time of LVAD implantation? A young patient series
Authors: Yavas Soner , Kervan Umit , Karahan Mehmet , Kocabeyoglu Sinan Sabit , Sert Dogan Emre , Ersoy Ozgur , Demirkan Burcu , Temizhan Ahmet , Ozatik Mehmet Ali 
Published: June 2023

Background: The aim of the study is to compare the results of patients who had moderate or severe tricuspid insufficiency (TI) at the time of left ventricular assist device (LVAD) implantation that did not undergo intervention. Methods: Between October 2013 and December 2019, 144 patients who did not undergo tricuspid valve repair (TVR) during LVAD implantation in our department were included in the study. The patients were divided into two groups according to the TI grade; Group 1: 106 patients (73.6%) with moderate TI and Group 2: 38 patients (26.4%) with severe TI. All patients were evaluated for mortality, need of inotrope, blood product transfusion, intensive care unit (ICU) stay, duration of mechanical ventilation, and early and late right ventricular failure (RVF). Minimally invasive technique was favored in patients with worse right ventricular (RV) function to prevent the need for postoperative RV support and bleeding. Results: The mean ages of the patients in the Group 1 and Group 2 were 46 ± 15 years (82% male), and 45 ± 11.2 years (81.5% males), respectively. Post-operative duration of mechanical ventilation, ICU stay, blood loss, and reoperations were similar ( p > 0.05). There was no significant difference in early RVF, pump thrombosis, stroke, bleeding, and 30-day mortality between groups ( p > 0.05). Incidence of late RVF was higher in Group 2 ( p < 0.05). Conclusion: Although the risk of late RVF may increase in patients with preoperative severe TI, not intervening in TI during LVAD implantation does not cause adverse clinical outcomes in the early period.
Effect of COVID-19 on sexual and reproductive functions of Egyptian males following recovery: A cross sectional study
Authors: GamalEl Din Sameh Fayek , Nabil Ismail Nashaat , Kaddah Amr , Abdel Salam Mohamed Ahmed , Korani Mahmoud Sayed , Hamed Mostafa Ahmed 
Published: June 2023

Introduction: We aimed to assess the sexual and the reproductive functions in males post COVID-19 infection in Beni-Suef Governorate. Methods: One hundred men were recruited in the current study. All participants were assessed by the Arabic validated version of the International Index of the Erectile Function 5 (ArIIEF-5), semen analysis, and Hospital Depression and Anxiety Scale (HADS). Finally, morning testosterone serum level was measured. Results: There were significant decreases in the sperm total motility, the ArIIEF-5 score, and serum total testosterone in the post COVID-19 patients after 3 months when compared to the controls. However, there were significant increases in the sperm total motility, the ArIIEF-5 score, and serum total testosterone in the post COVID-19 patients after 6 months group when compared to the post COVID-19 patients after 3 months group. Moreover, there was a significant increase in the HADS score in the post COVID-19 patients after 3 months when compared to the controls. In contrast, there was a significant decrease in the HADS score in the post COVID-19 patients after 6 months when compared to the post COVID-19 patients after 3 months. Conclusion: Our study had shown temporary impairment of sexual and reproductive functions in post COVID-19 convalescent males especially after 6 months from the onset of the infection.
Mechanism of Ziyuglycoside II-mediated Ferroptosis-related Proteins on the Proliferation and Metastasis of Human Lung Adenocarcinoma Cell Lines
Authors: Zhang Jian-hui , Xie Li-jun , Wang Han-lu , Chen Hui , Meng Xiao-rong , Lin Xing , Lin Xin-fu , Liao Li-sheng , Chen Ting , Luo Jie-Wei , Hong Lu-yu , Chen Xin 
Published: June 2023

Background Ferroptosis is a novel type of regulated cell death and targeting ferroptosis may be a potential treatment strategy for lung cancer. Ziyuglycoside II (ZYG II) has a significant inhibitory effect on the growth of lung cancer cells. However, the selective anti-tumor effect of the ZYG II against lung cancer has not been systemically studied. Objectives We combined ferrostatin-1 and erastin to explore the potential therapeutic mechanism of the ZYG II for lung adenocarcinoma. Materials and Methods A549 and H1299 cells were randomly divided into the control, ZYG II, ferroptosis inhibitor group (ZYG II+ ferrostatin-1), and erastin group (ZYG II+ erastin). Cell proliferation was detected using the CCK-8 method. Cell migration and invasion were evaluated using the Transwell assay. The protein expression levels of Glutathione Peroxidase 4 (GPX4), Solute Carrier Family 7 Member 11 (SLC7A11), and Transferrin receptor 1 (TFR1) were measured using western blotting. Results Compared with the control group, the cell proliferation, migration, and invasion abilities of the ZYG II group significantly decreased, the protein expression levels of GPX4 and SLC7A11 in the ZYG II group declined significantly, and the expression of TFR1 increased significantly ( p < 0.05). After adding ferrostatin 1 (ZYG II+ Ferrostatin 1), the cell proliferation, migration, and invasion abilities of the inhibited cells were significantly increased, the expression of GPX4 and SLC7A11 increased significantly and the expression of TFR1 decreased significantly ( p < 0.05). However, after adding the erastin (ZYG II+ erastin), the cell viability was further inhibited in A549, the expression levels of GPX4 and SLC7A11 were further inhibited and the expression of TFR1 was further increased ( p < 0.05). Conclusion ZYG II significantly inhibited the survival rate, proliferation, migration, and invasion ability of A549 and H1299 cells, possibly by inducing ferroptosis.
Primary Cleft Rhinoplasty with Custom Suture Needle for Alar Cartilage Repositioning in Unilateral Cleft Lip Patients: 3D Nasal Analysis
Authors: Kim Young Chul , Yoon Inah , Min Jae Cheong , Woo Soo Hyun , Kwon Soon Man , Oh Tae Suk 
Published: June 2023

Objective Primary nasal correction has been demonstrated to be a beneficial practice for patients with unilateral cleft lip and palate. However, there is currently no consensus among cleft surgeons regarding the ideal approach to addressing the malpositioned cartilages. This study aims to introduce a new surgical technique for repositioning deformed lower lateral cartilage during primary cleft rhinoplasty, which involves using a customized suture needle. Design Retrospective cohort study. Setting Tertiary university-affiliated hospital. Participants This retrospective study included 51 patients with unilateral cleft lip and palate who underwent primary rhinoplasty during the labial repair. Main outcome measures A morphological analysis of the nose was conducted using three-dimensional (3D) photographs. The cleft-to-noncleft side ratios of various nasal parameters, including nasal tip volume, nostril width, height, and area, were calculated at three time points: preoperative (T0), 3 months postoperative (T1), and 1 year postoperative (T2). Results Significant improvement (p < 0.05) was observed in the cleft-to-noncleft side ratios of nasal volume and nostril parameters. The nasal volume ratio and nostril height ratio remained stable, with no significant differences between the T1 and T2 periods. The nostril width ratio increased from 0.96 ± 0.13 at T1 to 1.05 ± 0.16 at T2, indicating an appropriate degree of surgical overcorrection of nasal width during primary lip repair. Conclusion Primary cleft rhinoplasty using a Chang's needle allows direct suture placement in the intercartilaginous region with minimally invasive approach, thereby preserving growth potential of the nose and restoring the nasal symmetry.
Hepatocellular Adenoma: Report of 2 Cases That Highlight the Relevance of Phenotype-Genotype Correlation in the Pediatric Population
Authors: Jiao Jingjing , Finberg Karin E. , Jain Dhanpat , Morotti Raffaella 
Published: June 2023

Background: Hepatocellular adenoma (HCA) in the pediatric population is very rare and there are only limited studies, especially with molecular characterization of the tumors. Main HCA subtypes recognized in the current WHO classification include HNF1A-inactivated HCA (H-HCA), inflammatory HCA (IHCA), β-catenin-activated HCA (b-HCA), and β-catenin-activated IHCA (b-IHCA) and sonic hedgehog HCA (shHCA) is reported as an emerging subtype. Methods: Clinical history, pathological information, and molecular studies for a series of 2 cases of pediatric HCA were reviewed. Results: Case 1 was a b-HCA characterized by somatic CTNNB1 S45 mutation in a 11-year-old male with Abernethy malformation. Case 2 was a H-HCA characterized by germline HNF1A variant (c.526+1G>A) in a 15-year-old male associated with maturity-onset diabetes of the young type 3 (MODY3). Conclusion: Our findings highlight the rarity of these 2 cases associated with adenomatosis, and the contribution of molecular/genetic analysis for proper sub-typing, prognosis and family surveillance.
Comparison of the effects of Valsalva maneuver, EMLA cream, and the combination of both in relieving pain of needle insertion on totally implantable access port: A randomized controlled study
Authors: Shi Simei , Zhu Ruiyun , Huang Xuxia , Qu Yanshan , Liang Qingtao , Lin Qiulian , Chen Youjing , Li Qiao , Liao Ting , Xin Mingzhu 
Published: June 2023

Background: Totally implantable access port (TIAP) is a subcutaneously implanted, long-term infusion device that is widely used in oncology patients. However, multiple needle insertions into TIAP may lead to pain, anxiety, and dread in patients. This study aimed to compare the effectiveness of Valsalva maneuver, eutectic mixture of local anesthetics (EMLA) cream, and the combination of both in relieving pain of cannulations on TIAP. Methods: This was a prospective randomized controlled study. We included 223 patients treated with antineoplastic drugs and randomized them into four groups: EMLA Group (Group E), control Group (Group C), Valsalva maneuver Group (Group V), and EMLA cream combing with Valsalva maneuver Group (Group EV). Each group was given the corresponding intervention before non-coring needle insertion. The data on pain scores and overall comfort were collected by numerical pain rating scale (NPRS) and visual analog scale (VAS). Results: Group E and Group EV experienced the least amount of pain scores in needle insertion, which was significantly lower than Group V and Group C ( p < 0.05). Meanwhile, Group E and Group EV obtained the highest comfort level, which was significantly higher than group C ( p < 0.05). Fifteen patients developed localized skin erythema after the application of medical Vaseline or EMLA cream and subsided within half an hour after rubbing. Conclusion: EMLA cream is a safe and effective way to alleviate pain during non-coring needle insertion in TIAP and enhance the overall comfort of patients. We recommend applying EMLA cream 1 h before needle insertion of TIAP, especially in patients having needle phobia or high pain scores from previous non-coring needle insertion.
A modern survey method for determining extraordinary loads based on multi-source online data
Authors: Xu Chi , Chen Jun , Li Jie 
Published: June 2023

Induced by unusual events such as people gatherings or furniture stacking, extraordinary loads rarely occur but can exhibit significant amplitudes. Though, sufficient statistical data are required to quantify the stochastic behavior of such loads, traditional surveys typically depend on manual on-site questionnaires, leading to low efficiency, occupant resistance and problematic weight estimation. In this study, multi-source online data are therefore used to propose a new survey method. Object weights are obtained from commodity information on e-commerce websites. Object quantities and occurrence intervals are acquired from questionnaires whose distribution employs an online user database. Using the proposed method, an online extraordinary load survey is conducted on residential buildings, covering 43,941 [Formula: see text] of floor area and collecting 14,186 weight samples. Three types of extraordinary loads are considered and their statistical properties of amplitudes and occurrence intervals are determined. The survey results indicate that the variations of amplitude statistics with area are well fitted by a form of the power function. On average, furniture stacking events are found to occur 0.07 time per year, but are most likely to exhibit a considerable amplitude. Finally, the acquired data are utilized to determine the fractile values of the lifetime maximum extraordinary loads.
Intra-cranial aneurysm treatment with contour or WEB – a single center comparison of intervention times and learning curves
Authors: Gärtner Friederike , Klintz Tristan , Peters Sönke , Bueno Neves Fernando , Mostafa Karim , Mahnke Justus , Hensler Johannes , Flüh Charlotte , Larsen Naomi , Jansen Olav , Wodarg Fritz 
Published: June 2023

Background and purpose Treating aneurysms with intra-saccular flow disruption is a feasible alternative to coil-embolization. Besides the established WEB device, the novel Contour Neurovascular System has emerged as a potentially easier alternative regarding sizing and deployment. We report the learning curve experienced at our center from the first 48 patients treated with Contour and compared it with 48 consecutive WEB cases. Methods Both groups were compared concerning intervention time, sizing failures leading to device changes and radiation dose. Additionally, we analyzed potential learning effects by comparing the first 24 Contour cases with our last 24 Contour cases and WEB cases respectively. Results Patient demographics, acute vs. incidental cases and aneurysm localization were comparable in both groups. The deployment time was faster in our 48 Contour cases (median: 22.0 ± 17.0 min), than in the WEB group (median: 27.5 ± 24.0 min). Total intervention time was similar for Contour (median: 68.0 ± 46.9 min) and WEB cases (median: 69.0 ± 38.0 min). Device implantation times in our WEB cases were slightly shorter in the later cases (median: 25.5 ± 24.1 min) than in the earlier (median: 28.0 ± 24.4 min) cases. In the Contour cohort, deployment times were similar for the first 24 cases (median: 22.0 ± 14.5 min) and the final 24 (median: 22.0 ± 19.4 min). Radiation dose was lower in the Contour group (1469.0 ± 1718 mGy*cm2 vs. 1788.0 ± 1506 mGy*cm2 using the WEB device). Less intra-procedural device changes were performed in the Contour cohort (6 of 48 cases, 12.5%), than in the WEB group (8 of 48 cases, 16.7%). Conclusion Aneurysm occlusion times and consequently radiation doses, as well as the amount of device changes were lower in the Contour group. Occlusion times did not differ in the first and last 24 Contour cases, leading to the assumption that the handling of Contour does not require extended training. A short training effect in occlusion times was noted, however, between the first and last WEB cases as shorter procedure times were seen in the latter cases.