bluuebunny/crossref_metadata_2025_split huggingface dataset:
Difficult-to-treat TAFRO syndrome associated with Sjögren’s syndrome successfully treated with Dual B cell depletion therapy: A case report
Authors: Watanabe Mitsuru , Okada Masato , Haji Yoichiro , Kato Mizuki , Ito Takanori , Amari Yui , Mizuno Yukina , Hozumi Mirai 
Published: March 2023

Abstract
TAFRO syndrome is a systemic inflammatory disease of unknown etiology. It is characterized by thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly. Herein, we report the case of a 60-year-old male with TAFRO syndrome. A few weeks after the patient developed an intermittent fever, he presented to our hospital with diarrhea, abdominal distension, and whole-body edema (face, extremities, and abdomen). Autoantibody and lip biopsy findings supported the diagnosis of primary Sjögren’s syndrome (pSS). High-dose steroids and tocilizumab were used to treat his refractory thrombocytopenia and ascites. However, systemic inflammation and renal dysfunction did not improve, resulting in temporary hemodialysis. Eventually, dual B-cell depletion therapy with rituximab and belimumab ameliorated the patient’s symptoms. About 16 weeks after discharge, the patient’s overall condition had improved. The TAFRO syndrome may be a severe manifestation of pSS. Considering the immunological context, B cell-targeted therapy provides new insights into improving this life-threatening disease and enables rapid steroid tapering.
A comparative analysis of phytochemicals vs synthetic drugs/nanomedicines in the treatment of Uterine Fibroid: A Systematic Review
Authors: Upadhyay Sonal , Bhushan Ravi , Pandey Vivek , Tripathi Anima , Sahu Alakh N. , Rani Anjali , Diwakar Amita , Gupta Rashmi , Dubey Pawan K. 
Published: March 2023

Abstract
Uterine fibroids (UFs) or leiomyoma is the most common gynaecological disorder affecting 70% of premenopausal women and one of the leading causes of infertility. To date, there is no specific therapy available except surgical intervention including hysterectomy or myomectomy. However, to manage UFs, lot of high cost medications are prescribed although they have serious side effects on women’s reproductive health. Recently an increasing trend has been seen on consuming dietary phytochemicals to control diverse gynaecological ailments. This review's goal is to provide a summary of the knowledge that is currently available regarding the mechanisms of action of various botanical medications with anti-uterine fibroid efficacy. The present results showed that dietary phytocompounds (Dehydroxyelephantopin, Butein, Capsaicin, Fisetin, Kaempferol, Resveratrol, Silibinin and Curcumin) could probably be effective as therapeutic compounds for uterine leiomyoma. These phytochemicals indicated their capability to regulate main fibroid promoting and initiating events for instance, proliferation, inflammation, angiogenesis and fibrosis in various experimental setup through modulating various signalling pathways, such as Smad 2/3, PI3K/AKT/mTOR, ERK 1/2 and β-catenin indicating that they could serve as targets for prevention and/or treatment of ULM. This review provides key molecular insights for development of phytochemical based novel personalized therapy for non-surgical management of ULMs which may help to avoid hysterectomy.
Open parotid gland biopsy under combined superficial cervical plexus and auriculotemporal nerve block
Authors: Mourouzis Constantinos , Panagiotopoulos Theodoros , Rallis George 
Published: March 2023

Abstract
Purpose
In high-risk patients often regional anaesthesia is more preferable and easier to perform compared to general anaesthesia. In this case report we evaluate the efficacy of combined superficial cervical plexus block and auriculotemporal nerve block in an open parotid gland biopsy.
Methods
Under combined superficial cervical plexus block and auriculotemporal nerve block we performed an open parotid gland biopsy in a patient who suffered from severe systemic problems posing high risk for general anaesthesia.
Results
The operation was uneventful, the duration of anaesthesia and analgesia until the first analgesic request were satisfactory.
Conclusion
It can be concluded that the combination of a regional anaesthesia technique with a superficial cervical plexus nerve block and auriculotemporal block is an alternative and safe technique for patients with parotid gland tumours requiring biopsy for setting a diagnosis.
Uncommon Presentation of Meningococcal Pneumonia in Vietnam: A Case Report
Authors: Trong Thang Khong , Nguyen Tung Phi , Nguyen Nam Ngoc Phuong , Vu Hoai Thi Thu , Nguyen Khanh Phuong Hoang 
Published: March 2023

Abstract
This is a case report of an elderly male patient who was diagnosed with meningococcal pneumonia resulting in respiratory failure. The patient had pre-existing conditions of chronic obstructive pulmonary disease (COPD) and prostate cancer. Upon admission, the patient exhibited symptoms such as a purulent cough producing sputum, dyspnea, decreased oxygen saturation, and chest X-ray images that were consistent with pneumonia. The bacteria responsible for the infection was identified as Neisseria meningitidis through bacterial culture, which was found to be antibiotic-resistant. The patient did not show any signs of septicemia or meningitis. Treatment was initiated with an appropriate antibiotic regimen, and the patient was discharged after demonstrating improvement over 10 days. Close contacts of the patient were given prophylactic antibiotics, and no secondary infections were recorded. In this article, we will present a detailed case report, and provide an overview of the epidemiology of meningococcal infections in Vietnam, as well as summarizing the clinical characteristics of meningococcal pneumonia cases globally.
Immunometabolic actions of trabectedin and lurbinectedin on human macrophages: Relevance for their antitumor activity
Authors: Bosca Lisardo , Povo-Retana Adrián , Fariñas Marco , Landauro-Vera Rodrigo , Mojena Marina , Alvarez-Lucena Carlota , Fernández-Moreno Miguel , Castrillo Antonio , Rosa Juan de la , Sánchez-García Sergio , Foguet Carles , Mas Francesc , Marin Silvia , Cascante Marta 
Published: March 2023

Abstract
In recent years, the central role of cell bioenergetics in regulating immune cell function and fate has been recognized, giving rise to the interest in immunometabolism, an area of research focused on the interaction between metabolic regulation and immune function. Thus, early metabolic changes associated with the polarization of macrophages into pro-inflammatory or pro-resolving cells under different stimuli have been characterized. Tumor-associated macrophages are among the most abundant cells in the tumor microenvironment; however, it exists an unmet need to study the effect of chemotherapeutics on macrophage immunometabolism. Here, we use a systems biology approach that integrates transcriptomics and metabolomics to unveil the immunometabolic effects of trabectedin (TRB) and lurbinectedin (LUR), two DNA-binding agents with proven antitumor activity. Our results show that TRB and LUR activate human macrophages toward a pro-inflammatory phenotype by inducing a specific metabolic rewiring program that includes ROS production, changes in the mitochondrial inner membrane potential, increased pentose phosphate pathway, lactate release, TCA cycle, serine and methylglyoxal pathways in human macrophages. Glutamine, aspartate, histidine, and proline intracellular levels are also decreased, whereas oxygen consumption is reduced. The observed immunometabolic changes could explain additional antitumor activities of these compounds and open new avenues to design therapeutic interventions that specifically target the immunometabolic landscape in the treatment of cancer.
Radiologic and histopathology features of follicular dendritic cell sarcoma in the stomach and abdominal cavity: a case report
Authors: zhan ting , xing shanshan , lu chunhua 
Published: March 2023

Abstract
It is highly uncommon for the gastrointestinal tract to be affected by follicular dendritic cell sarcoma(FDCS), a rare mesenchymal tumor that typically develops in the lymph nodes. Here, we describe a 64-year-old woman who discovered a lump in her left upper abdomen six months ago and was just taken to the hospital due to excruciating abdominal pain. An abdominal CT scan shows a soft tissue mass around the cardia. The patient underwent “radical total gastrectomy and esophagojejunostomy (Roux-Y anastomosis)”. Immunohistochemical and postoperative histopathology results were compatible with FDCS. The pathogenic characteristics of FDCS have received substantial discussion in the literature, however, the imaging characteristics of FDCS that involves the stomach and abdominal cavities have received less attention. This case report aims to enhance clinicians' understanding and diagnosis of dendritic cell sarcoma in the stomach and abdominal cavities of abdominal follicles and reduce the rate of clinical misdiagnosis.
Knowledge-Graph Based Multi-Domain Model Integration Method for Digital-Twin Workshops
Authors: Wang Xiangdong , Hu Xiaofeng , Ren Zijie , Tian Tianci , Wan Jiafu 
Published: March 2023

Abstract
The digital twin workshop is a new workshop operation paradigm that enables precise decision-making by fusing virtual and physical space. As a complex manufacturing system, the digital twin model of the workshop must integrate models from different domains in order to provide personalized services. The interoperability of multi-domain models and the dynamic update of parameters become obstacles. In this paper, a knowledge graph (KG)-based multi-domain model integration method for digital twin workshops is proposed. The multi-domain model integration architecture based on KG is consisted of model element, model ontology, model data, semantic integration and network connection. Then, the KG of multi-domain model for design, manufacturing and simulation is constructed through ontology modeling and knowledge extraction. On this basis, multi-domain model integration is realized through semantic inference and knowledge query. The model parameters are updated through file exchange during the dynamic simulation. Finally, multiple scenarios in the subassembly workshop for hull construction are used to verify the efficacy of the proposed method. During the assembly and welding of hull parts, the integration of the product model, equipment model, and simulation model is realized, which assists in meeting the service requirements of multiple business scenarios.
Dietary Diversity Practice and its associated factors among Adult People Living with HIV who go to health facilities in Ilu Abbabor Zone, South West Ethiopia: a facility-based cross-sectional study
Authors: negera ebissa , Belachew Tefera , Hassan Kalkidan 
Published: March 2023

Abstract
Introduction: Patients with HIV/AIDS are at high risk of consuming low-quality, monotonous food. The current study aimed to assess dietary intake adequacy and its associated factors among adult ART patients in Ilu Abbabor Zone, South West, Ethiopia. Methods: A facility-based cross-sectional study was conducted in six different health care facilities. Epi-Data was used for data entry, and SPSS version 21 was used for analysis. The level of significance in the final model was set at (P < 0.05). Results: The current study found that the majority of respondents (61.2%) had an inadequate dietary diversity practice. Adults on ART, on the other hand, have adequate dietary diversity practice. On the other hand, dietary diversity practice of adult people on ART, significantly associated with; being ever married [AOR = 0.366; 95% CI: (0.211, 0.634)], household number >/=5 [AOR = 2.45; 95% CI: (1.522, 4.088)], clinical stage of disease [AOR = 2.474; 95% CI (1.124, 5.444), and obesity [AOR = 0.290; 95% CI: (0.099, 0.846)]. Conclusions: The vast majority of study subjects (61.2%) had an inadequate dietary diversity practice. Furthermore, the adequacy of adult ART dietary intake was significantly related to marital status, household number, clinical stage of disease, and nutritional status. As a result, unmarried adult people living with HIV/AIDS must receive care and support. It is strongly advised to integrate nutrition with RH services, particularly family planning. Finally, early HIV/AIDS diagnosis and management, as well as nutrition, are critical for delaying the rapid progression of HIV to Acquired Immune Deficiency Syndrome (AIDS).
Catalytic activity of phenol oxidation over iron and cooper-exchanged pillared bentonite
Authors: CHELLAL Khalida , HAMIDOUCHE Fahim , Naima BOUDIEB , MEGUELLATI Zineb , TRARI Mohamed 
Published: March 2023

Abstract
Al, mixed Al-Fe and Al-Cu pillared clays were prepared. The solids were characterized by X-ray diffraction (XRD), N2 adsorption and H2-TPR. The dispersion of the cold clay suspension, before the pillaring, increases the basal spacing and the specific surface area. CWPO of phenol under mild conditions (25 °C, 1 atm) was carried out without correction of pH. Mixed Al-Fe and Al-Cu pillared clays have comparable performances, although they showed some differences in the H2O2 decomposition kinetics. A total conversion of H2O2 is obtained without the complete phenol conversion over mixed Al-Fe pillared clays suggesting the presence of active species in these catalysts. In a slight excess of H2O2, the activity increased for all iron-based clays catalysts with the increase in Fe content. A total conversion of phenol is obtained after 15 h of reaction over Fe/MR-AlFe(10) and after extending the reaction time to 30 h in the presence of Fe/MR-Al. While MR-AlFe(10) only converted 57.12% under the same conditions. MR-AlFe(10) has the greater basal space (17.44 Å) and is more active for H2O2 decomposition than Fe/MR-Al, which certainly allowed greater accessibility of the reactant to the iron species. Iron exchanged and post-pillared clay with mixed (Al-Fe) solution containing 10% of iron expressed as molar percentage {Fe/MR-AlFe (10)} was the most efficient for this reaction combining good catalytic activity with high stability against iron leaching (0.02%). It showed a total phenol degradation, the highest H2O2 decomposition (85.7%) and more than 80% of TOC removal after 15 h of reaction.
WITHDRAWN: Developing a novel cylindrical dielectric resonator antenna fed by microstrip line for millimeter-wave applications
Authors: Hasnaoui Yassine El , Mazri Tomader 
Published: March 2023

Abstract
The current work presents a novel cylindrical dielectric resonator (CDR) antenna geometry operating at 28 GHz for fifth-generation wireless communication networks (5G). Because of its high radiating power factor, the used dielectric resonator is regarded as a promising new candidate in the field of antennas. The CDR antenna is made up of a FR4 Epoxy Resin substrate with a relative permittivity of 4.4 and a height of 1.8 mm, to which we added a dielectric resonator with a relative permittivity of 8.3, a height of 1.5 mm and a radius of 1.34 mm and it fed by a single microstrip line. The designed antenna geometry was simulated and optimized with the electromagnetic solver HFSS, and the results were validated with the CST microwave studio software. The results allowed us to obtain an antenna radiation at the desired frequency of 28 GHz with an interesting return loss value, a good radiation pattern, a high gain, a large bandwidth and a high directivity. As a result, this antenna is suitable for a wide range of wireless satellite applications.
Impact of Pension Income on Healthcare Utilization of Older Adults in Rural China
Authors: Yan Peizhe , Li Fenghang , Nicholas Stephen , Maitland Elizabeth , Tan Jialong , Chen Chen , Wang Jian 
Published: March 2023

Abstract

OBJECTIVE
In China, rural residents experience poorer health conditions and a higher disease burden compared to urban residents but have lower healthcare services utilization. Rather than an insurance focus on enhanced healthcare services utilization, we focus on an income shock, in the form of China’s New Rural Pension Scheme (NRPS), on outpatient, inpatient and discretionary over-the-counter drug utilization by over 60-year-old rural NRPS residents.
METHODS
Providing a monthly pension of around RMB88(USD12.97), NRPS covered all rural residents over 60 years old. Fuzzy regression discontinuity design (FRDD) was employed to explore the NRPS causal effect on healthcare services utilization, measured by outpatient and inpatient visits and discretionary over-the-counter drug purchases. The nationwide China Health and Retirement Longitudinal Study (CHARLS) 2018 provided the data.
RESULTS
Without significant changes in health status and medication needs, 60-plus-year-old NRPS recipients significantly increased the probability of discretionary drug purchases by 33 percentage points. NRPS had no significant effect on the utilization of outpatient and inpatient utilization. The increase in the probability of discretionary drug purchases from the NRPS income shock was concentrated in healthier and low-income rural residents. Robustness tests confirmed that FRDD was a robust estimation method and our result is robust.
CONCLUSION
NRPS was an exogenous income shock that significantly increased the probability of discretionary over-the-counter drug purchases among over 60-year-old rural residents, but not the utilization of inpatient or outpatient healthcare services. Income remains an important constraint for rural residents to improve their health. We recommend policymakers consider including commonly used over-the-counter drugs in basic health insurance reimbursements for rural residents; provide health advice for rural residents to make discretionary over-the-counter drug purchases; and to mount an information campaign on over-the-counter drug purchasing in order to increase the health awareness of rural residents.
The combination of subclonal and clonal TP53 and KRAS alterations and poor response to first line therapy identifies ultra-high-risk patients with pediatric T-lymphoblastic leukemia (T-ALL)
Authors: Kempter Tamara , Richter-Pechanska Paulina , Michel Katarzyna , Rausch Tobias , Erarslan-Uysal Busra , Eckert Cornelia , Zimmermann Martin , Stanulla Martin , Schrappe Martin , Cario Gunnar , Köhrer Stefan , Kirschner-Schwabe Renate , Korbel Jan , Kunz Joachim , Kulozik Andreas 
Published: March 2023

Abstract
It has been the hypothesis of this study that clonal or subclonal variants of TP53 and KRAS that signify ultra-high risk in relapsed pediatric T-ALL indicate a poor prognosis at initial disease. We analyzed two cohorts of 160 and 226 BFM-patients, one consisting of 81 patients who later relapsed and 79 matched non-relapsing controls. Cohort-2 consisted of consecutive patients of whom 30 relapsed. In cohort-1 targeted sequencing revealed TP53 clonal and subclonal variants in 6/81 relapsing but in none of the non-relapsing patients (p=0.014). KRAS alterations occurred in 9/81 relapsing and 2/79 non-relapsing patients (p=0.032). No relapsing patient with TP53 and/or KRAS alterations survived, whereas 19/67 relapsing patients without such variants did (p=0.023). In cohort-2, 196 patients without relapse included 10 with TP53 or KRAS variants, all of whom were non-high risk based on treatment response. However, in the entire group of 386 patients the 188 patients with poor treatment response included 9 with such a variant of whom 8 relapsed and died. Of these, 5 had not undergone stem-cell-transplantation. In conclusion, these data show that subclonal and clonal TP53 and KRAS alterations at initial diagnosis indicate a dismal prognosis in children with T-ALL and poor treatment response.
Investigation of the stability and gastrointestinal digestion of camellia oleifera oil bodies as a natural delivery system for curcumin
Authors: Huang Zi-Wei , wu xuehui , lan xiaohe , zhang bing 
Published: March 2023

Abstract
We extracted Camellia oleifera oil bodies (COOB) from Camellia oleifera seeds (COS) to evaluate the function of oil bodies in delivering lipophilic bioactive compounds. Curcumin was loaded into COOB by pH shift method to form Curcumin-Camellia oleifera oil body emulsion (COB). Characterization analysis of COB with different mass fractions showed that COB had the best encapsulation efficiency (80.56%), particle size (2.17 μm), and environmental stress, could show excellent stability at salt concentrations from 100 to 500 mmol/L or pH values of 3 and 5 to 9 and at different temperature treatments when the addition of curcumin was 1%. Based on the digestion of COB in the gastrointestinal tract, a stable and sustained release of the active substance and, ultimately, a bioavailability of 81.51% of curcumin and 37.33 μmol/ml of free fatty acids were obtained in COOB carriers, which indicated COOB has the potential as a natural delivery system for lipophilic bioactive compounds.
Juxtaglomerular cell tumor：how to identify this rare disease by ultrasound?
Authors: Wang Li , Li Meiying , Jin Siqi , Ouyang Yunshu , Wang Fenglan , Lv Ke , Li Jianchu , Jiang Yuxin , Liu He , Zhu Qingli 
Published: March 2023

Abstract
Purpose：To study the value of ultrasound in the diagnosis of juxtaglomerular cell tumor (JGCT).
Methods: From January 2005 to July 2020, fifteen patients diagnosed as JGCT by surgical pathology in Peking Union Medical College Hospital were collected. All patients underwent preoperative ultrasound examination. The clinical, laboratory, ultrasound, computed tomography (CT), surgical, and pathological features of the patients were analyzed retrospectively.
Results: The 15 patients were 5 males and 10 females with a median age of 29 years (10~72 years). 14 of them had hypertension and one had normal blood pressure. The tumors were all solitary, with a median diameter of 1.5 cm (0.9-5.9 cm). Among the fifteen patients, eleven were corrected detected by preoperative ultrasound, and four were missed. There was a significant difference in tumor size (2.64±1.48 cm vs. 1.23±0.21 cm) and whether the tumor protruded outward (9/11 vs. 0/4) between the ultrasound-detected group and the ultrasound-missed group (p=0.010, p=0.011). Of the 11 tumors detected by ultrasound, four were extremely hypoechoic, two were hypoechoic, three were isoechoic, and two were hyperechoic. Color Doppler showed no blood flow in five tumors no more than 2cm, and mild blood flow in six tumors more than 2cm.
Conclusions: JGCT is rare, and has characteristic clinical manifestations. Diagnosis should be suspected in case of secondary hypertension, particularly in young women, if no renal vascular cause is found. Ultrasound, combined with clinical manifestations, was helpful for the diagnosis.