bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unmasked insulinoma occasioned by severe hypoglycemic coma immediately postpartum: a case report
Authors: Matsumoto Kiyoshi , Watanabe Miyu , Takao Ken , Takahashi Hirokazu , Daido Hisashi , Shibata Toshiro , Hirose Tokuyuki , Kato Takehiro , Mizuno Masami , Hirota Takuo , Suwa Tetsuya , Horikawa Yukio , Murakami Takaaki , Yabe Daisuke 
Published: August 2023

Abstract
Background
Insulinoma in women during pregnancy and postpartum is very rare; approximately 65% of cases are diagnosed early in pregnancy and ~ 35% immediately after delivery, few being found in middle or late pregnancy, likely due to increased insulin resistance seen after early-stage pregnancy. We successfully treated a case of insulinoma in which severe hypoglycemic coma immediately after delivery occasioned detailed investigation and diagnosis.

Case presentation
Our patient experienced hypoglycemic coma in the 3rd month of pregnancy (initially considered due to her hyperemesis gravidarum) that improved spontaneously during the gestational period. No abnormalities of plasma glucose or body weight were found in regular checkups during her pregnancy; however, recurrence of hypoglycemic coma after delivery led us to suspect insulinoma. While contrast enhanced computer tomography and endoscopic ultrasonography (EUS) initially failed to detect a tumor in the pancreas, selective arterial calcium stimulation test revealed an insulin-secreting tumor localized in the pancreatic body. She then underwent spleen-preserving distal pancreatectomy; a 10-mm tumor positive for chromogranin A, synaptophysin and insulin was identified.

Conclusions
Although pregnancy can mask insulinoma-associated symptoms and make diagnosis challenging, hypoglycemic episodes during early pregnancy, which were observed in this case, are suggestive of insulinoma. Importantly, in this case, accurate preoperative localization of the tumor enabled prompt curative surgery after delivery. Thus, clinical vigilance for the occurrence of insulinoma and its localization is appropriate for pregnant women suffering severe hypoglycemia.
Presenters at chiropractic research conferences 2010–2019: is there a gender equity problem?
Authors: Aspinall Sasha L , Nim Casper Glissmann , Harsted Steen , Miller Amy , Øverås Cecilie K , Roseen Eric J , Young James J , Søgaard Karen , Kawchuk Greg , Hartvigsen Jan 
Published: August 2023

Abstract
Background
Presenting at professional and scientific conferences can be an important part of an individual’s career advancement, especially for researchers communicating scientific findings, and can signal expertise and leadership. Generally, women presenting at conferences are underrepresented in various science disciplines. We aimed to evaluate the gender of presenters at research-oriented chiropractic conferences from 2010 to 2019.

Methods
We investigated the gender of presenters at conferences hosted by chiropractic organisations from 2010 to 2019 that utilised an abstract submission process. Gender classification was performed by two independent reviewers. The gender distribution of presenters over the ten-year period was analysed with linear regression. The association of conference factors with the gender distribution of presenters was also assessed with linear regression, including the gender of organising committees and abstract peer reviewers, and the geographic region where the conference was hosted.

Results
From 39 conferences, we identified 4,340 unique presentations. Women gave 1,528 (35%) of the presentations. No presenters were classified as gender diverse. Overall, the proportion of women presenters was 30% in 2010 and 42% in 2019, with linear regression demonstrating a 1% increase in women presenting per year (95% CI = 0.4–1.6%). Invited/keynote speakers had the lowest proportion of women (21%) and the most stagnant trajectory over time. The gender of conference organisers and abstract peer reviewers were not significantly associated with the gender of presenters. Oceanic conferences had a lower proportion of women presenting compared to North America (27% vs. 36%).

Conclusions
Overall, women gave approximately one-third of presentations at the included conferences, which gradually increased from 2010 to 2019. However, the disparity widens for the most prestigious class of keynote/invited presenters. We make several recommendations to support the goal of gender equity, including monitoring and reporting on gender diversity at future conferences.
A multidimensional nomogram combining clinical factors and imaging features to predict 1-year recurrence of low back pain with or without radicular pain after spinal manipulation/mobilization
Authors: Sun Dai , Liu Yang-yang , Luo Dan , Wu Ye-qi , Yan Zhi-qiang , Liang Yun-qi , Huang Xue-yan , Lin Jia-long , Luo Hua-song , Wang Rui 
Published: August 2023

Abstract
Background
In this retrospective study, we aimed to develop a nomogram to predict recurrence during a 1-year period of spinal manipulation/mobilization (SM/M) in patients with low back pain (LBP) with greater pain intensity, more severe comorbid conditions, or a neuropathic component.

Methods
A total of 786 consecutive patients with LBP treated with SM/M as primary therapy were divided into training (n = 545) and validation (n = 241) sets. Cox regression analyses were used to assess the relative value of clinical factors and lumbar magnetic resonance imaging features associated with recurrence during the 1-year period. Predictors of recurrence with significant differences were used to construct a nomogram in the training set. We evaluated the performance of the model on the training and validation sets to determine its discriminative ability, calibration, and clinical utility. The prognostic value of the nomogram for predicting recurrence was assessed using Kaplan–Meier analysis and time-dependent receiver operating characteristic analyses.

Results
A nomogram comprising hospitalization time, previous history of LBP, disease duration, lumbar range of motion, lower extremity tendon reflex, muscle strength, ratio of herniation to uncompressed dural sac area, and Pfirrmann classification was established for recurrence during a 1-year period after SM/M in patients with LBP. Favorable calibration and discrimination were observed in the nomogram training and validation sets (C-index 0.753 and 0.779, respectively). Decision curve analysis confirmed the clinical utility of the nomogram. Over a 1-year period, the nomogram showed satisfactory performance in predicting recurrence in LBP after SM/M.

Conclusion
We established and validated a novel nomogram that can accurately predict a patient's risk of LBP recurrence following SM/M. This realistic prognostic model may aid doctors and therapists in their decision-making process and strategy optimization for non-surgical treatment of LBP using SM/M.
Renal cancer secretome induces migration of mesenchymal stromal cells
Authors: Popławski Piotr , Zarychta-Wiśniewska Weronika , Burdzińska Anna , Bogusławska Joanna , Adamiok-Ostrowska Anna , Hanusek Karolina , Rybicka Beata , Białas Alex , Kossowska Helena , Iwanicka-Nowicka Roksana , Koblowska Marta , Pączek Leszek , Piekiełko-Witkowska Agnieszka 
Published: August 2023

Abstract
Background
Advanced renal cell carcinoma (RCC) is therapeutically challenging. RCC progression is facilitated by mesenchymal stem/stromal cells (MSCs) that exert remarkable tumor tropism. The specific mechanisms mediating MSCs’ migration to RCC remain unknown. Here, we aimed to comprehensively analyze RCC secretome to identify MSCs attractants.

Methods
Conditioned media (CM) were collected from five RCC-derived cell lines (Caki-1, 786-O, A498, KIJ265T and KIJ308T) and non-tumorous control cell line (RPTEC/TERT1) and analyzed using cytokine arrays targeting 274 cytokines in addition to global CM proteomics. MSCs were isolated from bone marrow of patients undergoing standard orthopedic surgeries. RCC CM and the selected recombinant cytokines were used to analyze their influence on MSCs migration and microarray-targeted gene expression. The expression of genes encoding cytokines was evaluated in 100 matched-paired control-RCC tumor samples.

Results
When compared with normal cells, CM from advanced RCC cell lines (Caki-1 and KIJ265T) were the strongest stimulators of MSCs migration. Targeted analysis of 274 cytokines and global proteomics of RCC CM revealed decreased DPP4 and EGF, as well as increased AREG, FN1 and MMP1, with consistently altered gene expression in RCC cell lines and tumors. AREG and FN1 stimulated, while DPP4 attenuated MSCs migration. RCC CM induced MSCs’ transcriptional reprogramming, stimulating the expression of CD44, PTX3 and RAB27B. RCC cells secreted hyaluronic acid (HA), a CD44 ligand mediating MSCs’ homing to the kidney. AREG emerged as an upregulator of MSCs’ transcription.

Conclusions
Advanced RCC cells secrete AREG, FN1 and HA to induce MSCs migration, while DPP4 loss prevents its inhibitory effect on MSCs homing. RCC secretome induces MSCs’ transcriptional reprograming to facilitate their migration. The identified components of RCC secretome represent potential therapeutic targets.

Graphical abstract
Optimal partial regularity of discontinuous subelliptic systems with VMO coefficients related to Hörmander’s vector fields
Authors: Zhu Yan , Wang Jialin , Liao Dongni 
Published: August 2023

AbstractIn this paper, we study discontinuous subelliptic systems with VMO coefficients related to Hörmander’s vector fields. In the case of growth exponential $p\geq 2$
p
≥
2
, the regularity results of the partial Hölder continuity of weak solutions are established based on the $\mathcal{A}$
A
-harmonic approximation method under the controllable growth condition.
Herpesviruses reactivation following COVID-19 vaccination: a systematic review and meta-analysis
Authors: Shafiee Arman , Amini Mohammad Javad , Arabzadeh Bahri Razman , Jafarabady Kyana , Salehi Seyyed Amirhossein , Hajishah Hamed , Mozhgani Sayed-Hamidreza 
Published: August 2023

Abstract
Background
The reactivation of herpesviruses (HHV) in COVID-19 patients is evident in the literature. Several reports have been published regarding the reactivation of these viruses (HSV, VZV, EBV, and CMV) among those who got COVID-19 vaccines. In this study, we aimed to review the current evidence to assess whether HHVs reactivation has any association with the prior administration of COVID-19 vaccines.

Methods
A systematic search was conducted on 25 September 2022 in PubMed/MEDLINE, Web of Science, and EMBASE. We included all observational studies, case reports, and case series which reported the reactivation of human herpesviruses following administration of COVID-19 vaccines.

Results
Our systematic search showed 80 articles that meet the eligibility criteria. Among the evaluated COVID-19 vaccines, most of the vaccines were mRNA based. Evidence from observational studies showed the possible relation between COVID-19 vaccine administration and VZV and HSV reactivation. The results of our proportion meta-analysis showed that the rate of VZV reactivation among those who received the COVID-19 vaccine was 14 persons per 1000 vaccinations (95% CI 2.97–32.80). Moreover, our meta-analysis for HSV reactivation showed the rate of 16 persons per 1000 vaccinations (95% CI 1.06–46.4). Furthermore, the evidence from case reports/series showed 149 cases of HHV reactivation. There were several vaccines that caused reactivation including BNT162b2 mRNA or Pfizer–BioNTech (n = 76), Oxford-AstraZeneca (n = 22), mRNA-1273 or Moderna (n = 17), Sinovac (n = 4), BBIBP-CorV or Sinopharm (n = 3), Covaxin (n = 3), Covishield (n = 3), and Johnson and Johnson (n = 1). Reactivated HHVs included varicella-zoster virus (VZV) (n = 114), cytomegalovirus (CMV) (n = 15), herpes simplex virus (HSV) (n = 14), Epstein-Barr virus (EBV) (n = 6), and HHV-6 (n = 2). Most cases reported their disease after the first dose of the vaccine. Many patients reported having comorbidities, of which hypertension, diabetes mellitus, dyslipidemia, chicken pox, and atrial fibrillation were common.

Conclusion
In conclusion, our study showed the possible association between COVID-19 vaccination and herpesvirus reactivation. The evidence for VZV and HSV was supported by observational studies. However, regarding other herpesviruses (EBV and CMV), further research especially from observational studies and clinical trials is required to elucidate the interaction between COVID-19 vaccination and their reactivation.
Chimeric antigen receptor engineered natural killer cells for cancer therapy
Authors: Zhang Yalan , Zhou Weilin , Yang Jiangping , Yang Jinrong , Wang Wei 
Published: August 2023

AbstractNatural killer (NK) cells, a unique component of the innate immune system, are inherent killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells and good tolerance of healthy cells, NK cells have been successfully employed in adoptive cell therapy to treat cancer patients. In recent years, the clinical success of chimeric antigen receptor (CAR)-T cells has proven the vast potential of gene-manipulated immune cells as the main force to fight cancer. Following the lessons learned from mature gene-transfer technologies and advanced strategies in CAR-T therapy, NK cells have been rapidly explored as a promising candidate for CAR-based therapy. An exponentially growing number of studies have employed multiple sources of CAR-NK cells to target a wide range of cancer-related antigens, showing remarkable outcomes and encouraging safety profiles. Clinical trials of CAR-NK cells have also shown their impressive therapeutic efficacy in the treatment of hematological tumors, but CAR-NK cell therapy for solid tumors is still in the initial stages. In this review, we present the favorable profile of NK cells as a potential platform for CAR-based engineering and then summarize the outcomes and strategies of CAR-NK therapies in up-to-date preclinical and clinical investigations. Finally, we evaluate the challenges remaining in CAR-NK therapy and describe existing strategies that can assist us in devising future prospective solutions.
Petrophysical interpretation of logging-while-drilling borehole measurements in the presence of electrical anisotropy, mud-filtrate invasion, noise, and well deviation effects
Authors: Bennis Mohamed , Torres-Verdín Carlos 
Published: August 2023

Petrophysical interpretation of logging-while-drilling (LWD) borehole measurements in the presence of electrical anisotropy, mud-filtrate invasion, noise, and well deviation effects remains a challenge in formation evaluation. In high-angle and horizontal (HAHZ) wells penetrating electrically anisotropic sandstones, phase and attenuation apparent resistivity logs often exhibit values larger than resistivity parallel to bedding planes. Consequently, traditional interpretation methods often fail to accurately estimate hydrocarbon saturation when using only the long-spacing phase apparent resistivity log (P40H) in petrophysical calculations. We implement two approaches (analytical and Bayesian) to estimate horizontal and vertical resistivities from apparent resistivity measurements. The first analytical approach is based on the numerical simulation of LWD resistivity measurements using synthetic models under various conditions of electrical anisotropy and well inclination to derive analytical models. The relative error of analytical approximations is less than 6%. In the presence of measurement noise and shoulder-bed effects, we implement a Bayesian method for well-log inversion and uncertainty quantification. The relative error of Bayesian inversion is less than 2%. Estimates of horizontal and vertical resistivities then can be used for petrophysical analysis. A challenging set of synthetic and field examples of HAHZ wells penetrating electrically anisotropic formations is selected for examination and verification of the new methods. For radial lengths of invasion less than 20 cm (8 in), sensitivity analysis indicates that the effects of conductive mud-filtrate invasion on long-spacing resistivity logs are negligible. The long-spacing phase (P40H) and attenuation (A40H) apparent resistivities are used to estimate horizontal and vertical resistivities. In the field examples under study, electrical anisotropy is caused by intercalated laminations of coarse- and fine-grained sandstones; the volumetric concentration of shale is negligible. Considering that Archie’s parameters are direction dependent, sensitivity analysis indicates that the effective value of the saturation exponent parallel to bedding planes is less sensitive to the volumetric concentration of fine-grained sandstone layers compared with the saturation exponent perpendicular to bedding planes. Thus, water saturation of grain-laminated sandstones in HAHZ wells can be estimated using horizontal resistivity with Archie’s parameters that are consistent with petrophysical interpretations performed in vertical wells. Estimates of water saturation in the field examples using horizontal resistivity agree with saturation-height models. Compared with conventional interpretation methods that use P40H as the formation resistivity, the new approach improved the estimation of hydrocarbon saturation by 10%.
Challenging Outlook of Caring for Adolescents and Young Adults With Cancer in Brazil: Results of a Nationwide Survey
Authors: Kazzi Ana I.M. , Diniz Paulo H.C. , Mano Max , Nogueira-Rodrigues Angélica 
Published: August 2023

PURPOSE The global burden of cancer in adolescents and young adults (AYAs) emerges as a major public health issue, in which remarkable challenges and unmet needs are evident. Because of sociodemographic inequalities, initiatives to change this scenario need to be expanded globally, particularly to low-middle–income countries (LMICs). This study aimed to gain information about the standards of AYA cancer care in Brazil from the physician's perspective. METHODS Physicians involved in AYA cancer care were invited to answer a national online survey. The questions covered several aspects from health care's demographics to specialized services availability, such as fertility and genetic counseling. The availability of a specialized AYA cancer care facility was the primary study end point, and the findings were stratified by region and treatment setting (public v private). RESULTS Among the physicians who responded (N = 249), 90% reported no access to a specialized AYA service. Only 20% had access to a fertility specialist, and 30% to a survivorship program in their institutions. Even external referrals to medical specialties were challenging, with 24% of the physicians reporting challenges. Despite the potential cardiotoxicity related to treatments, 43% of the respondents reported to refer patients for cardio-oncologists hardly ever. Furthermore, 36% of physicians had never enrolled AYA patients into clinical trials and 42% had never ordered a genetic test. Lack of specialized human resources was particularly evident in Northern Brazil, and delays in cancer diagnoses were frequent. CONCLUSION This first study addresses standards of AYA cancer care across Brazil. Importantly, the data disclose significant infrastructural gaps, implying that major investments in training and infrastructure are urgently needed. These data may mirror other LMICs reality.
Visualization of the biphasic calcium wave during fertilization in Caenorhabditis elegans using a genetically encoded calcium indicator
Authors: Toperzer Katie M. , Brennan Savannah J. , Carroll David J. , Guisbert Eric A. , Kim Guisbert Karen S. 
Published: August 2023

ABSTRACT
Fertilization is a critical step in development, yet internal fertilization events are notoriously difficult to visualize. Taking advantage of the calcium response that is a hallmark of sperm-egg fusion, we adapted the genetically encoded calcium indicator jGCaMP7s to visualize the moment of fertilization in Caenorhabditis elegans using fluorescence. We termed this tool the ‘CaFE’ reporter, for ‘calcium during fertilization in C. elegans’. The CaFE reporter produced a robust signal that recapitulated the previously reported, biphasic nature of the calcium wave and had no significant deleterious effects on worm physiology or fecundity. Calcium waves were not observed at the restrictive temperature in the spe-9(hc88) strain, in which sperm can still trigger meiotic maturation but can no longer fuse with the oocyte. Demonstrating the utility of the CaFE reporter, we analyzed polyspermy induced by inhibition of egg-3 via RNAi and observed late calcium waves in the uterus. This finding provides support to the idea that calcium release is not restricted to the first sperm fusion event during polyspermy. Establishment of the CaFE reporter in the genetically tractable and optically transparent worm provides a powerful tool to dissect the oocyte-to-embryo transition inside a living animal.
The Transition from Song to Poetry in Latvian Literature in the Second Half of the 19th Century
Authors: Grudule Māra 
Published: August 2023

The Latvian nation is a singing nation. The Singing Revolution and similar song- and singing-related references are traditionally associated with the image of Latvians. The origins of written Latvian are also related to song: the oldest known Christian song in Latvian, dating from 1530, is also one of the oldest examples of Latvian-language text.
In the second half of the 18th century, as a result of transferring from a German to a Latvian cultural space, a new genre of song was created by the German pastor Gotthard Friedrich Stender, the secular, didactic and sentimental ziņģe (a term coined from the German verb singen, ‘to sing’). As the level of education among Latvians was low and most information spread by word of mouth, the German pastors and the first generation of Latvian poets made use of ziņges as an informative tool. Around the middle of the 19th century, the Latvian national revival began. Without denying the importance of Latvian folk songs in the creation of national culture, the main focus of this article is on the secular ziņģes that were adopted from the German literary tradition, which up until the second half of the 19th century were a favourite tool for entertainment (singing) and spreading information orally. As the level of literacy among Latvians rose, the ziņģes receded to the periphery of the literary landscape, paving the way for a new concept for denoting a rhythmic text that was for the first time not melody-bound: dzeja, or ‘poetry’. The emergence of the new concept in 1869, which was related to the Latvian national revival and the formation of a national literary culture, at the same time also marked a turning point from orality to literacy in Latvian society.
Fair Trade factory farms: a false solution to a real problem
Authors: Canning Anna 
Published: August 2023

The dairy industry is in crisis in countries throughout the world. Rising industrialization in the sector coupled with corporate consolidation is harming small-scale farmers. Indeed, low milk prices and control over regional processing benefits processors and brands, who gain profits even as farmers and farmworkers suffer.
Around the globe, various initiatives have endeavoured to address the issues facing dairy production through a Fair Trade lens. This article briefly surveys these initiatives and then examines in depth a new ‘Fair Trade dairy’ label recently released by Fair Trade USA that has been developed and piloted with Chobani and Dairy Farmers of America.
This article examines the particulars of that standard as well as posing the question whether the values and principles of Fair Trade are even applicable to industrial animal agriculture.