bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthy lifestyle and cognitive aging: What is the gap behind prescribing healthier lifestyle?
Authors: Aravena José M. 
Published: April 2023

AbstractAlthough there is a clear link between lifestyle and cognitive health, the dissonance between observational and intervention studies results reveals gaps in the knowledge of how to translate healthy lifestyles into better cognitive health for the population. This letter discusses gaps in interpreting observational studies linking healthy lifestyles and cognitive health in older adults. The main goal is to briefly highlight the necessity of understanding and incorporating intrinsic and extrinsic drivers of engagement in healthy lifestyles before prescribing and implementing individual and multicomponent programs.
Selective detection of nitrofurantoin by histidine‐capped silver nanoclusters with blue luminescence
Authors: Guo Yuyu , Chu Yiqing , Sun Xiaojuan , Cao Songhao , Li Xin , Li Xinyue 
Published: April 2023

AbstractIn view of the significance of nitrofurantoin, there is an urgent need for efficient analytical methods for accurate detection of nitrofurantoin. Considering their superior fluorescence performance and rarity of reports regarding nitrofurantoin detection by fluorescent silver nanoclusters (Ag NCs), Ag NCs with good stability and uniform size were synthesized through a simple method by protection of histidine (His) and reduction of ascorbic acid (AA). Based on the quenching by nitrofurantoin, Ag NCs were applied successfully in the detection of nitrofurantoin with high sensitivity. In the range of 0.5–150 μM, a linear relationship was found between ln(F0/F) and nitrofurantoin amounts. Static quenching and inner filter effect were proved to be the main quenching mechanisms. Significantly superior selectivity and satisfactory recovery results in bovine serum indicate that Ag NCs provide a better choice for nitrofurantoin detection.
Assessment of alcohol‐induced aggressive behavior in zebrafish (Danio rerio): A practical class
Authors: Lopes Andressa Rubim , Leandro Luana Paganotto , Mariano Maria Vitória Takemura , Posser Thais , Franco Jeferson 
Published: April 2023

AbstractEthanol (EtOH) is among the most consumed drugs in the world. The behavior of humans after ingestion of this drug is characteristic: At low doses it may be excitatory and at higher doses, it may induce depressant/sedative effects. Similar effects are observed in the zebrafish experimental model (Danio rerio), which has about 70% genetic similarity with humans and has been widely used in numerous research. With the objective of improving the learning of biochemistry students, this work aimed to develop a practical exercise in the laboratory for students to observe the behavioral repertoire of zebrafish under the effects of exposure to ethanol. Through this practical class, the students were able to observe the similarity of the behavior of the animal model with that of humans, showing its importance for the consolidation of knowledge, awakening in the students an interest in science and its applications in everyday life.
Using game concepts to improve programming learning: A multi‐level meta‐analysis
Authors: Costa Joana M. 
Published: April 2023

AbstractGamification has been widely used in education due to its application to different contexts. The vast number of possibilities allows the creation of learning strategies that lead to students' success. Despite the high acceptance of gamification among several authors in educational contexts, there are many dispersed studies with high differences in their results. Although gamification impacts motivation, interest, and engagement, its effect on students' learning outcomes needs to be clarified. This study aims to investigate the effects of gamification on programming learning and the impact of the most used game concepts on knowledge acquisition. A multi‐level meta‐analysis was conducted on studies above K‐12 to understand the effects of gamification in programming learning. From 15 combined effect sizes, it was analyzed the effect of points, badges, levels, avatars, leaderboards, and the number of elements used. The results showed that gamification leads to a significant increase in the results (Cohen's d = 0.4) but essentially due to the use of levels (p < .05). Using badges, points, avatars, and leaderboards showed no significant effect on programming learning, suggesting that these elements may be more beneficial to motivating or engaging the students. Gamification can be efficient in programming learning, but it is recommended the use of levels.
Impact of therapeutic strategy on disease‐free and overall survival of early‐stage cervical cancer: Surgery alone versus preoperative radiation
Authors: Mahiou Katia , Vincent Laura , Peignaux‐Casasnovas Karine , Costaz Hélène , Padeano Marie‐Martine , Amet Alix , Dabakuyo Sandrine , Mamguem Kamga Ariane , Bengrine‐Lefevre Leila , Coutant Charles 
Published: April 2023

AbstractBackground and ObjectivesThere is no international consensus for management of early‐stage cervical cancer (ESCC). This study aimed to retrospectively investigate disease‐free survival (DFS) and overall survival (OS) in patients with ESCC according to the therapeutic strategy used, surgery alone versus preoperative radiation following by surgery.MethodsData were retrospectively collected from 1998 to 2015 using the Gynecological Cancer Registry of the Côte d'Or. The inclusion criteria were FIGO 2018 ≤ IB2; squamous cell carcinoma, adenocarcinoma or adenosquamous type. Survival curves were compared using the log‐rank test.ResultsOne hundred twenty‐six patients were included. Median survival was 90 months. There was no significant difference in DFS (HR = 0.91, 95%CI [0.32–2.53], p = 0.858) or in OS between surgery alone versus preoperative radiation following by surgery (HR = 0.97, 95%CI [0.31–2.99], p = 0.961). In the subgroup of patients with stage ≥IB1, there was no significant difference in DFS (HR = 3.26, p = 0.2) or in OS (HR = 3.87, p = 0.2).ConclusionOur study did not identify any difference in survival according to the treatment strategy. Preoperative radiation following by surgery can be an alternative to surgery alone for ESCC.
Optimized hierarchical radial basis function neural networks by developing coronavirus herd immunity optimizer for solid oxide fuel cells
Authors: Zou Ting , Chen Zhihui , Razmjooy Saeid 
Published: April 2023

SummaryA new blackbox technique has been presented in this article for model estimation of solid oxide fuel cells (SOFCs) for providing better results. The proposed method is based on a hierarchical radial basis function (HRBF). The presented method is then developed by a new modified metaheuristic called developed coronavirus herd immunity algorithm (DCHIA). The suggested model has been named DCHIA‐HRBF. The proposed model is then trained by some data and prepared for identification and prediction. The model is then analyzed and put in comparison with several latest techniques for validation of the efficiency of the technique. It is also verified by the empirical data to prove its validation with the real data. The results show that the best cost for the performance index which is the network error, is achieved by the proposed developed coronavirus herd immunity algorithm with about 119.442, which is satisfying for the considered function and target against the other state‐of‐the‐art methods. As a result, the simulation results specified that the suggested DCHIA‐HRBF delivers high effectiveness as an identifier and prediction tool for the SOFCs.
Overseeding aeschynomene and N fertilization effects on forage characteristics, N fixation, and N2O‐N emissions of bahiagrass pastures
Authors: Garzon Jaime , Vendramini Joao M. B. , Silveira Maria L. , Dubeux Jose Carlos B. , Liao Hui‐Ling , Sollenberger Lynn E. , da Silva Hiran M. S. , Gomes Vinicius C. , de Oliveira Hugo M. R. 
Published: April 2023

AbstractAeschynomene (Aeschynomene americana L.) is a warm‐season annual legume forage used in tropical and subtropical regions; however, there is limited information on agronomic and environmental benefits of aeschynomene when overseeded into bahiagrass (Paspalum notatum Flüggé) swards. The objective of this study was to evaluate the effects of overseeding aeschynomene or applying N fertilizer to existing bahiagrass on forage characteristics, atmospheric N fixation, and N2O‐N emissions. The study was conducted in Ona, FL, from April 2019 to March 2021. Treatments were the split‐plot arrangement of bahiagrass‐aeschynomene or bahiagrass monoculture (main plot) and N fertilization level (0 or 60 kg N ha−1; subplot), distributed in a randomized complete block design with four replicates. Nitrogen fixation was estimated in plots receiving no N fertilization. The static chamber technique was used to estimate N2O‐N emissions. Overseeding aeschynomene did not increase forage accumulation (mean = 1300 kg dry matter [DM] ha−1 harvest−1) or N2O emissions (mean = 15 g N2O‐N ha−1 per day), but increased forage crude protein (CP) concentration (from 98 to 108 g kg−1) when compared to bahiagrass monoculture. Nitrogen fertilization increased forage accumulation (from 1200 to 1400 kg DM ha−1 per harvest) but it did not affect aeschynomene N fixation (84% N derived from atmospheric fixation [Ndfa]). Nitrous oxide emissions had significant temporal variability across all treatments; however, there were no differences in accumulated N2O‐N emissions among treatments (mean = 2.4 kg N2O‐N ha−1 per year). Overseeding aeschynomene is an effective management practice to increase forage CP concentration in pastures without increasing N2O‐N emissions.
Evidence for feasibility of implementing online brief cognitive‐behavioral therapy for eating disorder pathology in the workplace
Authors: Toro Carla T. , Payne Agatha , Jackson Tabitha , Russell Sean , Daly Guy , Waller Glenn , Meyer Caroline 
Published: April 2023

AbstractObjectiveCBT‐T is a brief (10‐week) cognitive‐behavioral therapy for non‐underweight eating disorders. This report describes the findings from a single center, single group, feasibility trial of online CBT‐T in the workplace as an alternative to health service settings.MethodThis trial was approved by the Biomedical and Scientific Research Ethics committee, University of Warwick, UK (reference 125/20‐21) and was registered with ISRCTN (reference number: ISRCTN45943700). Recruitment was based on self‐reported eating and weight concerns rather than diagnosis, potentially enabling access to treatment for employees who have not previously sought help and for those with sub‐threshold eating disorder symptoms. Assessments took place at baseline, mid‐treatment (week 4), post‐treatment (week 10), and follow‐up (1 and 3 months post‐treatment). Participant experiences following treatment were assessed using quantitative and qualitative approaches.ResultsFor the primary outcomes, pre‐determined benchmarks of high feasibility and acceptability were met, based on recruiting >40 participants (N = 47), low attrition (38%), and a high attendance rate (98%) over the course of the therapy. Participant experiences revealed low previous help‐seeking for eating disorder concerns (21%). Qualitative findings indicated a wide range of positive impacts of the therapy and the workplace as the therapeutic setting. Analysis of secondary outcomes for participants with clinical and sub‐threshold eating disorder symptoms showed strong effect sizes for eating pathology, anxiety and depression, and moderate effect sizes for work outcomes.DiscussionThese pilot findings provide a strong rationale for a fully powered randomized controlled trial to determine the effectiveness of CBT‐T in the workplace.Public SignificanceThis study demonstrates the feasibility of implementing an eating disorders intervention (online CBT‐T) in the workplace as an alternative to traditional healthcare settings. Recruitment was based on self‐reported eating and weight concerns rather than diagnosis, potentially enabling access to treatment for employees who had not previously sought help. The data also provide insights into recruitment, acceptability, effectiveness, and future viability of CBT‐T in the workplace.
Genome size variation withinCrithmum maritimum: Clues on the colonization of insular environments
Authors: Roxo Guilherme , Brilhante Miguel , Moura Mónica , de Sequeira Miguel Menezes , Silva Luís , Costa José Carlos , Vasconcelos Raquel , Talhinhas Pedro , Romeiras Maria M. 
Published: April 2023

AbstractAngiosperms present an astonishing diversity of genome sizes that can vary intra‐ or interspecifically. The remarkable new cytogenomic data shed some light on our understanding of evolution, but few studies were performed with insular and mainland populations to test possible correlations with dispersal, speciation, and adaptations to insular environments. Here, patterns of cytogenomic diversity were assessed among geographic samples (ca. 114) ofCrithmum maritimum(Apiaceae), collected across the Azores and Madeira archipelagos, as well as in adjacent continental areas of Portugal. Using flow cytometry, the results indicated a significant intraspecific genome size variation, spanning from reduced sizes in the insular populations to larger ones in the mainland populations. Moreover, there was a tendency for an increase in genome size along the mainland populations, associated with lower temperatures, higher precipitation, and lower precipitation seasonality. However, this gradient might be the result of historic phylogeographical events associated with previous dispersal and extinction of local populations. Overall, our findings provided evidence that smaller genome sizes might play a critical role in the colonization of islands, corroborating other studies that argue that organisms with smaller genomes use fewer resources, having a selective advantage under insular environments. Although further studies are needed to improve our understanding of the mechanisms underlying genome size evolution on islands, conservation strategies must be promoted to protect the rich cytogenomic diversity found amongC. maritimumpopulations, which occur in coastal areas that are particularly threatened by human activity, pollution, invasive species, and climate changes.
Personality in juvenile Atlantic cod ecotypes and implications for fisheries management
Authors: Beukeboom Rosanne , Phillips Joseph S. , Ólafsdóttir Guðbjörg Ásta , Benhaïm David 
Published: April 2023

AbstractAnimals show among‐individual variation in behaviors, including migration behaviors, which are often repeatable across time periods and contexts, commonly termed “personality.” These behaviors can be correlated, forming a behavioral syndrome. In this study, we assessed the repeatability and correlation of different behavioral traits, i.e., boldness, exploration, and sociality, and the link to feeding migration patterns in Atlantic cod juveniles. To do so, we collected repeated measurements within two short‐term (3 days) and two long‐term (2 months) intervals of these personality traits and genotypes of the Pan I locus, which is correlated with feeding migration patterns in this species. We found high repeatabilities for exploration behavior in the short‐ and long‐term intervals, and a trend for the relationship between exploration and the Pan I locus. Boldness and sociality were only repeatable in the second short‐term interval indicating a possible development of stability over time and did not show a relation with the Pan I locus. We found no indication of behavioral syndromes among the studied traits. We were unable to identify the existence of a migration syndrome for the frontal genotype, which is the reason that the link between personality and migration remains inconclusive, but we demonstrated a possible link between exploration and the Pan I genotype. This supports the need for further research that should focus on the effect of exploration tendency and other personality traits on cod movement, including the migratory (frontal) ecotype to develop management strategies based on behavioral units, rather than treating the population as a single homogeneous stock.
Mule deer fawn recruitment dynamics in an energy disturbed landscape
Authors: Murphy Kilian J. , Roberts David R. , Jensen William F. , Nielsen Scott E. , Johnson Sandra K. , Hosek Brian M. , Stillings Bruce , Kolar Jesse , Boyce Mark S. , Ciuti Simone 
Published: April 2023

AbstractWildlife population dynamics are modulated by abiotic and biotic factors, typically climate, resource availability, density‐dependent effects, and predator–prey interactions. Understanding whether and how human‐caused disturbances shape these ecological processes is helpful for the conservation and management of wildlife and their habitats within increasingly human‐dominated landscapes. However, many jurisdictions lack either long‐term longitudinal data on wildlife populations or measures of the interplay between human‐mediated disturbance, climate, and predator density. Here, we use a 50‐year time series (1962–2012) on mule deer (Odocoileus hemionus) demographics, seasonal weather, predator density, and oil and gas development patterns from the North Dakota Badlands, USA, to investigate long‐term effects of landscape‐level disturbance on mule deer fawn fall recruitment, which has declined precipitously over the last number of decades. Mule deer fawn fall recruitment in this study represents the number of fawns per female (fawn:female ratio) that survive through the summer to October. We used this fawn recruitment index to evaluate the composite effects of interannual extreme weather conditions, energy development, and predator density. We found that density‐dependent effects and harsh seasonal weather were the main drivers of fawn fall recruitment in the North Dakota Badlands. These effects were further shaped by the interaction between harsh seasonal weather and predator density (i.e., lower fawn fall recruitment when harsh weather was combined with higher predator density). Additionally, we found that fawn fall recruitment was modulated by interactions between seasonal weather and energy development (i.e., lower fawn fall recruitment when harsh weather was combined with higher density of active oil and gas wells). Interestingly, we found that the combined effect of predator density and energy development was not interactive but rather additive. Our analysis demonstrates how energy development may modulate fluctuations in mule deer fawn fall recruitment concurrent with biotic (density‐dependency, habitat, predation, woody vegetation encroachment) and abiotic (harsh seasonal weather) drivers. Density‐dependent patterns emerge, presumably due to limited quality habitat, being the primary factor influencing fall fawn recruitment in mule deer. Secondarily, stochastic weather events periodically cause dramatic declines in recruitment. And finally, the additive effects of human disturbance and predation can induce fluctuations in fawn fall recruitment. Here we make the case for using long‐term datasets for setting long‐term wildlife management goals that decision makers and the public can understand and support.
An interlaboratory capillary zone electrophoresis‐UV study of various monoclonal antibodies, instruments, and ε‐aminocaproic acid lots
Authors: Wiesner Rebecca , Zagst Holger , Lan Wenkui , Bigelow Stewart , Holper Peter , Hübner Göran , Josefsson Leila , Lancaster Claire , Lo Lili , Lößner Christopher , Lu Huixin , Neusüß Christian , Rüttiger Carolin , Schlecht Johannes , Schürrle Philipp , Selsam Alexander , van der Burg Debbie , Wang Shao‐Chun , Zhu Yunxiao , Wätzig Hermann , Sänger‐van de Griend Cari 
Published: April 2023

AbstractCapillary zone electrophoresis ultraviolet (CZE‐UV) has become increasingly popular for the charge heterogeneity determination of mAbs and vaccines. The ε‐aminocaproic acid (eACA) CZE‐UV method has been used as a rapid platform method. However, in the last years, several issues have been observed, for example, loss in electrophoretic resolution or baseline drifts. Evaluating the role of eACA on the reported issues, various laboratories were requested to provide their routinely used eACA CZE‐UV methods, and background electrolyte compositions. Although every laboratory claimed to use the He et al. eACA CZE‐UV method, most methods actually deviate from He's. Subsequently, a detailed interlaboratory study was designed wherein two commercially available mAbs (Waters’ Mass Check Standard mAb [pI 7] and NISTmAb [pI 9]) were provided to each laboratory, along with two detailed eACA CZE‐UV protocols for a short‐end, high‐speed, and a long‐end, high‐resolution method. Ten laboratories participated each using their own instruments, and commodities, showing excellence method performance (relative standard deviations [RSDs] of percent time‐corrected main peak areas from 0.2% to 1.9%, and RSDs of migration times from 0.7% to 1.8% [n = 50 per laboratory], analysis times in some cases as short as 2.5 min). This study clarified that eACA is not the main reason for the abovementioned variations.
Wrestling with Public Input on an Ethical Analysis of Scientific Research
Authors: Martschenko Daphne Oluwaseun , Callier Shawneequa L. , Garrison Nanibaa’ A. , Lee Sandra Soo‐Jin , Turley Patrick , Meyer Michelle N. , Parens Erik 
Published: April 2023

AbstractBioethicists frequently call for empirical researchers to engage participants and community members in their research, but don't themselves typically engage community members in their normative research. In this article, we describe an effort to include members of the public in normative discussions about the risks, potential benefits, and ethical responsibilities of social and behavioral genomics (SBG) research. We reflect on what might—and might not— be gained from engaging the public in normative scholarship and on lessons learned about public perspectives on the risks and potential benefits of SBG research and the responsible conduct and communication of such research. We also provide procedural lessons for others in bioethics who are interested in engaging members of the public in their research.
Vaccination uptake for pertussis and influenza vaccines in pregnancy among different practices at a single institution
Authors: Nieuwoudt C. , Reeder C. F. , Moss H. K. , van Nes J. B. , Schoutko W. W. , Jeter J. W. , Fortner K. B. 
Published: April 2023

AbstractObjectiveThe authors investigated tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) and influenza vaccination during pregnancy following Advisory Committee on Immunization Practices' (ACIP's) recommendation for antenatal pertussis vaccination.MethodsA retrospective chart review was performed in 2019 of women receiving prenatal care at our institution between January 1, 2014 and December 31, 2018. Receipt of ACIP‐recommended vaccines were examined using Current Procedural Terminology codes to identify initiation of prenatal care, then administration of Tdap and influenza vaccines. Data were examined by individual practice (university faculty, community physicians, obstetrics and gynecology (OBGYN) residents, and family medicine residents, practice staff composition, vaccination protocol use, and insurance status. Statistical analyses were performed using χ2 testing and χ2 testing of linear trend.ResultsWithin our cohort (n = 17 973), highest vaccination uptake occurred in the university‐based OBGYN faculty practice (Tdap = 58.2%, influenza = 56.5%) with lowest uptake in the OBGYN resident practice (Tdap = 28.6%, influenza = 18.5%). Higher uptake occurred in practices with standing orders, more advanced practice providers, lower provider to nursing ratios, and lower rates of Medicaid insurance.ConclusionThese data demonstrated higher vaccination uptake with standing orders, more advanced practice providers, and lower provider to nurse ratios. Future work optimizing practice staff composition and vaccination protocols may increase vaccine uptake.