bluuebunny/crossref_metadata_2025_split huggingface dataset:
mRNA COVID‐19 vaccination early in pregnancy and the risk of spontaneous abortion in an international pregnancy registry
Authors: Mansour Omar , Hernandez‐Diaz Sonia , Wyszynski Diego F. 
Published: February 2023

AbstractPurposemRNA COVID‐19 vaccines are used in pregnant populations whether advertently or inadvertently. However, evidence on the safety of these vaccines during pregnancy is limited. The objective of this study is to evaluate the effect of BNT162b2 (Pfizer‐BioNTech) and mRNA‐1273 (Moderna) vaccination during the first 20 weeks of gestation on the risk of spontaneous abortion (SAB).MethodsAll pregnant women who received at least one dose of BNT162b2 or mRNA‐1273 and enrolled in the COVID‐19 Vaccines International Pregnancy Exposure Registry (C‐VIPER) were prospectively followed from enrollment until 20 weeks of gestation, SAB, or loss to follow‐up. Baseline demographics, vaccination information, and pregnancy outcomes were collected via monthly online self‐administered questionnaires, vaccination certificates, and medical records. Life tables were used to calculate the cumulative risk of SAB. Cox regression was used to estimate the hazard ratio (HR) comparing the two vaccines groups stratified by country of residence and gestational age at enrollment.ResultsAmong 6840 participants who received at least one dose of BNT162b2 or mRNA‐1273 at any time in pregnancy between Jan‐Sep, 2021, 2129 met the inclusion criteria (1576 received BNT162b2 and 553 mRNA‐1273). The two groups were balanced in terms of baseline characteristics. There were 37 SABs, with an overall 13.4% estimated cumulative risk by 20 weeks of gestation, which is similar to the expected risk in the population. The HR of SAB comparing mRNA‐1273 to BNT162b2 was 1.46 (95% CI: 0.66, 3.22).ConclusionThe C‐VIPER data show no evidence that mRNA COVID‐19 vaccines increase the risk of SAB.
Synthesis and properties of biophenol‐furfural based bioresin for curing of styrene butadiene rubber
Authors: Koley Riya , Chattopadhyay Santanu , Bhowmick Anil K. 
Published: February 2023

AbstractIn the present work, biophenol and furfural‐based resol resin was synthesized and utilized for the very first time to cure styrene butadiene rubber (SBR). The reaction was studied over a range of times, temperatures, pH, and furfural to biophenol ratios to fix the optimum conditions. Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy revealed the functional groups and chemical structure of the synthesized resin, respectively. An exothermic peak for the resin curing appeared at 143°C in the differential scanning calorimetry thermogram of the resin. Then, the biophenol‐furfural resin was utilized for the curing of SBR. The synthesized resin increased the tensile strength of the raw rubber from 0.20 ± 0.01 MPa to 1.22 ± 0.10 MPa at 10 phr loading, and the crosslink density was 2.56 × 10−5 mol/mL. The activation energy for curing SBR containing 10 phr resin was 97 kJ/mol. The storage modulus of the resin‐cured compound was improved. The glass transition temperature of the raw SBR was also shifted from −43.8 to −42.3°C when 10 phr resin was used for the curing. Hence, for the first time, this work reported the utilization of biophenol‐biosourced furfural resin to cure rubbers.
Treatment of hepatocellular carcinoma with in situ generated plasma‐activated air‐driven water mist
Authors: Saadawy Hossam , Fathi Esraa M. , Elsayed Islam , Anzour Janset S. , Zaki Ahmed , El Shaer Mohamed , Emara Marwan 
Published: February 2023

AbstractSince the development of cold atmospheric plasma (CAP), substantial and significant usage of CAP applications was introduced in medicine. Here, we developed two combined sources of plasma to produce in situ plasma‐activated air‐driven water mist (PAAWM). The first is generated using air as a feed gas, while the second is plasma‐activated water generated by the ignition of plasma within the air‐driven water mist. Both contribute to the plasma jet generation of PAAWM. The antitumor efficacy of PAAWM was evaluated against two hepatocellular carcinoma cell lines (SNU‐449 and SNU‐475). The generated PAAWM was efficient in the treatment of both chemosensitive and chemoresistant hepatocellular carcinoma cells. These results may support using PAAWM alone or in combination with other treatment modalities.
Susceptibility monitoring and comparative gene expression of susceptible and resistant strains of Spodoptera frugiperda to lambda‐cyhalothrin and chlorpyrifos
Authors: do Nascimento Antonio Rogério Bezerra , Rodrigues Juliana Gonzales , Kanno Rubens Hideo , de Amaral Fernando Semmelroth Assunção e , Malaquias José Bruno , Silva‐Brandão Karina Lucas , Cônsoli Fernando Luís , Omoto Celso 
Published: February 2023

AbstractBACKGROUNDSpodoptera frugiperda (J. E. Smith) is a widespread agricultural pest with several records of resistance to different insecticides and Bt proteins, including the neurotoxic insecticides chlorpyrifos (organophosphate) and lambda‐cyhalothrin (pyrethroid). Here, we (i) characterized and monitored the susceptibility of field populations of S. frugiperda to chlorpyrifos (194 populations) and lambda‐cyhalothrin (197 populations) collected from major maize‐growing regions of Brazil from 2003 to 2016, and (ii) compared gene expression levels of laboratory‐selected, chlorpyrifos‐ and lambda‐cyhalothrin‐resistant strains to a susceptible reference strain (Sf‐ss) of S. frugiperda.RESULTSThe susceptibility monitoring detected average survival ranging from 29.3% to 36.0% for chlorpyrifos, and 23.1% to 68.0% for lambda‐cyhalothrin. The resistance ratio of the chlorpyrifos‐resistant strain (Clo‐rr) was 25.4‐fold and of the lambda‐cyhalothrin‐resistant strain (Lam‐rr) was 21.5‐fold. We identified 1098 differentially expressed genes (DEGs) between Clo‐rr and Sf‐ss, and 303 DEGs between Lam‐rr and Sf‐ss. Functional analyses of the DEGs revealed the up‐regulation of several detoxification enzymes, mainly cytochrome P450 belonging to CYP3 and CYP6 clans. Genes associated with regulatory processes, such as the forkhead box class O (FoxO) transcription factor were also up‐regulated. Variant analysis of target‐site mutations for both pesticides identified the A201S and F290V mutations in acetylcholinesterase‐1, both occurring in heterozigosis in the Clo‐rr S. frugiperda strain.CONCLUSIONOur data show that the overexpression of the enzymatic detoxification machinery is the main difference to explain the resistance of Clo‐rr and Lam‐rr strains of S. frugiperda to chlorpyrifos and lambda‐cyhalothrin, although a target‐site mutation also contributes to the Clo‐rr resistance to chlorpyrifos. © 2023 Society of Chemical Industry.
The quest for balance between capturing data and model complexity: A quantitative clinical pharmacology approach applied to monoclonal antibodies
Authors: Pressly Michelle A. , Peletier Lambertus A. , Zheng Songmao , Sharma Vishnu D. , Lien Yi Ting (Kayla) , Wang Weirong , Zhou Honghui , Schmidt Stephan 
Published: February 2023

AbstractThe main objective of this tutorial is to provide the readers with a roadmap of how to establish increasingly complex target‐mediated drug disposition (TMDD) models for monoclonal antibodies. To this end, we built mathematical models, each with a detailed visualization, starting from the basic TMDD model by Mager and Jusko to the well‐established, physiologically based model by Li et al. in a step‐wise fashion to highlight the relative importance of key physiological processes that impact mAb kinetics and system dynamics. As the models become more complex, the question of structural and parameter identifiability arises. To address this question, we work through a trastuzumab case example to guide the modeler's choice for model and parameter optimization in light of the context of use. We leave the readers of this tutorial with a brief summary of the advantages and limitations of each model expansion, as well as the model source codes for further self‐guided exploration and hands‐on analysis.
Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects
Authors: Shahcheraghi Seyed Hossein , Salemi Fateme , Small Shlomo , Syed Suliman , Salari Farzam , Alam Waqas , Cheang Wai San , Saso Luciano , Khan Haroon 
Published: February 2023

AbstractUsually, in aerobic metabolism, natural materials including nucleic acids, proteins, and lipids can experience auxiliary injury by oxidative responses. This damage produced by reactive oxygen/nitrogen species has been identified as “oxidative stress.” As a natural polyphenol got from red wine and peanuts, resveratrol is one of the most eminent anti‐aging mixtures. Based on many studies', resveratrol hinders destructive effects of inflammatory causes and reactive oxygen radicals in several tissues. The nuclear erythroid 2‐related factor 2 is a factor related to transcription with anti‐inflammatory, antioxidant possessions which is complicated by enzyme biotransformation and biosynthesis of lipids and carbohydrates. This review provides current understanding and information about the character of resveratrol against oxidative stress and regulation of inflammation via Nrf2 signaling pathway.
Contribution of risk and resilience factors to anxiety trajectories during the early stages of the COVID‐19 pandemic: A longitudinal study
Authors: Shilton Tal , Mancini Anthony D. , Perlstein Samantha , DiDomenico Grace E. , Visoki Elina , Greenberg David M. , Brown Lily A. , Gur Ruben C. , Gur Raquel E. , Waller Rebecca E. , Barzilay Ran 
Published: February 2023

AbstractThe COVID‐19 pandemic, and the response of governments to mitigate the pandemic's spread, resulted in exceptional circumstances that comprised a major global stressor, with broad implications for mental health. We aimed to delineate anxiety trajectories over three time‐points in the first 6 months of the pandemic and identify baseline risk and resilience factors that predicted anxiety trajectories. Within weeks of the pandemic onset, we established a website (covid19resilience.org), and enrolled 1362 participants (n = 1064 from US; n = 222 from Israel) who provided longitudinal data between April–September 2020. We used latent growth mixture modelling to identify anxiety trajectories and ran multivariate regression models to compare characteristics between trajectory classes. A four‐class model best fit the data, including a resilient trajectory (stable low anxiety) the most common (n = 961, 75.08%), and chronic anxiety (n = 149, 11.64%), recovery (n = 96, 7.50%) and delayed anxiety (n = 74, 5.78%) trajectories. Resilient participants were older, not living alone, with higher income, more education, and reported fewer COVID‐19 worries and better sleep quality. Higher resilience factors' scores, specifically greater emotion regulation and lower conflict relationships, also uniquely distinguished the resilient trajectory. Results are consistent with the pre‐pandemic resilience literature suggesting that most individuals show stable mental health in the face of stressful events. Findings can inform preventative interventions for improved mental health.
Chirality: An inescapable concept for the pharmaceutical, bio‐pharmaceutical, food, and cosmetic industries
Authors: Kandula Jony Susanna , Rayala VVS Prasanna Kumari , Pullapanthula Radhakrishnanand 
Published: February 2023

AbstractChirality resides in diverse fields such as pharmaceuticals, food, bio‐pharmaceuticals, and cosmetics. Drugs used in treating various disease conditions, the majority of the plant secondary metabolites, various chemicals used in cosmetics, and distinct flavoring agents used in food industries exhibit chirality. In this context, there is an obligation to extend the analysis to chiral aspects. Attempts have been made to summarize the systematic, successful approaches for enantiomeric production via both enantio‐selective synthesis and the resolution of enantiomers using various analytical techniques including crystallization, chiral chromatography, capillary electrophoresis, kinetic resolution mediated by enzymes. Efforts have also been made to describe the regulatory guidance regarding bridging studies in the milieu of chiral switching. The majority of the monoclonal antibodies, growth factors, blood components, deoxyribonucleic acids, enzymes, and even vaccines for various diseases like cancer, polio, malaria, tetanus, hepatitis B, cholera, diphtheria bind differently to the receptors because the majority of drug binding and antibody binding receptors are also exhibiting chirality. Recent advancements in the various analytical techniques involved in the chiral analysis of food to preserve the authenticity of distinct flavors and cosmetics to identify safer enantiomers and reduce side effects both to humans and the environment are described.
Universelle Hochleistungsstützen aus hochfesten Stählen ohne Schweißen
Authors: Nonn Jonas , Janiak Till , Jalaeeyan Asieh , Wolters Kevin , Feldmann Markus , Zehfuß Jochen , Claßen Martin 
Published: February 2023

AbstractIn den letzten Jahren werden Stahlverbundstützen aus normalfesten Stählen in der Baupraxis immer seltener eingesetzt. Grund für den Marktverlust ist u. a. die Preis‐ und Technologieentwicklung der konkurrierenden Stahlbeton‐Fertigteilbauweise. So wird erst durch den Einsatz hochfester Baustähle die Stahlbauweise für den Stützenmarkt im Hochbau wieder relevant. In Deutschland allerdings stehen der Verwendung höchstfester Baustähle derzeit große Hindernisse in Form von normativen Regelungen entgegen, die die Anwendung in Stahlverbundstützen praktisch ausschließen. Allerdings haben Hohlprofil‐Verbundstützen mit eingestellten Vollkernquerschnitten unter Verwendung von höchstfesten Stählen ohne Schweißverbindungen das Potenzial, Marktanteile im Hochbau zurückzugewinnen. Im Rahmen eines von der AiF (Arbeitsgemeinschaft industrieller Forschungsvereinigungen) geförderten Forschungsprojekts wird diese Thematik experimentell und theoretisch untersucht. Der vorliegende Aufsatz soll das Konzept solcher neuartigen Verbundstützen mit hochfesten Stählen aufzeigen und erste Einsichten in die experimentellen Forschungsergebnisse geben. Neben Stützenversuchen im Kalt‐ und Heißfall werden Kleinteilversuche durchgeführt, um verschiedene Einflussfaktoren zu untersuchen und die Grundlagen für neue und zugleich einfache Entwurfs‐ und Konstruktionsprinzipien zu schaffen.
Oxygen‐vacancy‐containing cerium oxide nanoparticle‐decorated nanonetwork‐structured carbon toward high‐performance lithium–sulfur batteries
Authors: Li Chuanfa , Ma Pengwei , Lin Shenghao , Cen Zongheng , Huang Junlong , Cui Yin , Li Shimei , Liu Shaohong , Fu Ruowen , Wu Dingcai 
Published: February 2023

AbstractLithium–sulfur (Li–S) batteries have been regarded as promising next‐generation energy‐storage devices owing to their inherently high theoretical energy density. Unfortunately, the poor capacity and cycling life caused by severe polysulfide shuttle effect and sluggish redox kinetics in sulfur cathodes greatly impede the practical application of Li–S batteries. Herein, a new class of nanonetwork‐structured carbon decorated with oxygen‐vacancy‐containing cerium oxide nanoparticles (NSC–CeO2−x), in which carbon skeleton is composed of highly conductive carbon nanotube core welded by hybrid carbon shell, has been developed via one‐step heating treatment of hybrid molecular brush and further employed as functional interlayer to modify separator of Li–S battery. Owing to the synergistic effect of the highly active CeO2−x nanoparticles and the three‐dimensional carbon nanonetwork in enhancing the preservation of the soluble polysulfides and boosting the redox kinetics of sulfur species, the NSC–CeO2−x significantly promotes the electrochemical performance of sulfur cathode. As a result, the as‐constructed Li–S batteries exhibit an ultrahigh initial sulfur utilization of 92.9% and an extremely large capacity of 751 mA h g−1 at a high rate of 5 C. Remarkably, a stable capacity of 728 mA h g−1 over 300 cycles at 1 C is also achieved.
Optimization of beam parameters for coupling beam pile structure foundations under vertical loading
Authors: Yousheng Deng , Keqin Zhang , Wenjie Li , Qian Song , Erli Ma 
Published: February 2023

SummaryThe coupling beam pile structure is a new type of foundation for high‐rise buildings that can be easily constructed. The vertical load‐bearing characteristics of the coupling beam pile structure are examined using indoor model tests and numerical calculations to optimize the beam structure's parameters. The validity of the finite element model is then confirmed, and the beam structure's width, length, and stiffness are changed to examine their effects on the load‐bearing capacity. The results show that the load–settlement curve of the structure varies slightly, with a 45.10% increase in load‐carrying capacity compared to a pile group foundation for the same load, and that the coupling beam can support heavier loads while also distributing the tension of the loads. The width and length of the coupling beam are proportional to the load‐carrying capacity of the structure. The width of the coupling beam should be kept at 3.5 times the pile diameter since any wider width results in the “wall group effect,” which reduces the foundation's ability to support the weight. The coupling beam's short length, which should be kept above 4.5 times the pile diameter, can aid in reducing the “pile group effect.” The coupling beam stiffness can be changed according to the scenario in practice; there is no upper limit. The coupling beam stiffness is 5 times the reference value when it has the strongest force transmission capacity but has essentially little impact on the structure's load‐carrying capacity.
Potential use of foundry sand and furnace blast sand for fabrication of visibly active composite to promote circular economy/waste management for treating real agro‐industrial wastewater
Authors: Puri Sonali , Verma Anoop 
Published: February 2023

AbstractA two‐step process of coagulation/flocculation followed by a simultaneous dual process (photocatalysis + photo‐Fenton) is developed to treat real pulp and paper (P and P) industry wastewater. The rigid stout color wastewater was treated using a sunlight‐responsive and cost‐effective Fe‐TiO2 composite using recirculating photoreactor with a total working volume of 4 L. The key point of this study is that the treatment is done in very less time (90 min), and it incorporates the idea of circular economy, as the composite is fabricated out of industrial rejects. The further intensification of the process was done by proper process optimization of both approaches. With an initial concentration of stout color (0.78 AU) and chemical oxygen demand (COD) (2200 mg/L), the optimized conditions gave a good reduction in % color and % COD, that is, 64.1% and 41.8% (1280 mg/L) after coagulation/flocculation and 89.74% and 53.12% (600 mg/L) after dual, respectively. The composite was characterized by using various techniques like field emission scanning electron microscopy (FESEM)/energy dispersive X‐ray analysis (EDAX), UV–visible diffuse reflectance spectroscopy (UV–vis DRS), and X‐ray diffraction (XRD) to check the catalyst composition, complexes formed between Fe‐TiO2, and the catalyst intactness in both fresh and 50 times recycled composite. A trapping study was also performed using various quenchers to confirm that OH• plays a major role in the present study among other radicals produced where 55–60% drop in color removal was seen. In order to foresee the commercial use of this study, the process' cost was also estimated.Practitioner points
Industrial waste products were used to fabricate inert support that promoted the idea of circular economy/waste management.
Iron from the waste used to execute photo‐Fenton process along with forming Fe‐TiO2 complex to make it visibly active composite.
Enhanced production of OH radicals facilitated removal of stout color and COD from the real pulp and paper industry wastewater in just 90 min.
Coagulation/flocculation followed by dual technique proved to be the best approach out of three different approaches applied.
Composite showed excellent durability even after 50 recycles.
Asymptotic property for eigenelements of the Laplace operator in a domain with an oscillating boundary
Authors: Jaouabi Ahlem , Khelifi Abdessatar 
Published: February 2023

AbstractThis work deals with the variations of eigenvalues and eigenfunctions for the Laplace operator in a bounded domain of with Dirichlet boundary conditions, a part of which boundary, depending on a small parameter ε, is rapidly oscillating. By using surface potentials we show that the eigenvalues are exactly built with the characteristic values of meromorphic operator‐valued functions that are of Fredholm type with index 0. Then, we proceed from the generalized Rouché's theorem to study the splitting problem.
Weak asymptotic solution of one dimensional zero pressure dynamics system in the quarter plane
Authors: Joseph Kayyunnapara Divya 
Published: February 2023

AbstractIn this paper we study a system of equations which appear in the modelling of many physical phenomena. Initially this system appeared in description of the large scale structure formation. Recently it is derived as a second order queueing model. We construct weakly asymptotic solutions of the initial boundary value problem for the system and interaction of waves in the quarter plane with boundary Riemann solution centered at (0,0) and Riemann solution centered at a point .
Next-to-next-to-leading-order QCD corrections to J/ψ plus ηc production at the B factories
Authors: Huang Xu-Dong , Gong Bin , Wang Jian-Xiong 
Published: February 2023

Abstract
In this paper, we calculate the next-to-next-to-leading-order (NNLO) QCD corrections to e+e− → J/ψ + ηc at the B factories. After including the NNLO corrections, the cross section of e+e−→ J/ψ +ηc is enhanced by about 17%, and the perturbative series of the prediction shows the convergent behavior. It is also found that the contributions from bottom quark starts at the $$ {\alpha}_s^3 $$

α
s
3

-order, which is about 2.4% of the total prediction. The renormalization scale μR dependence of the cross section is reduced at the NNLO level, but the prediction is sensitive to the charm quark mass mc. By considering the uncertainties caused by renormalization scale μR, charm quark mass mc and the NRQCD factorization scale μΛ, our prediction shows agreement with the BABAR and BELLE measurements within errors.
Pohozaev identity for Finsler anisotropic problems
Authors: Montoro Luigi , Sciunzi Berardino 
Published: February 2023

AbstractIn this paper we derive the Pohozaev identity for quasilinear equations $$\begin{aligned} -{\text {div}}(B'(H(\nabla u))\nabla H(\nabla u))=g(x, u) \quad \text{ in }\,\, \Omega , \quad \quad {(E)} \end{aligned}$$

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div
(

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)

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)

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=
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(
x
,
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)

in

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,

(
E
)

involving the anisotropic Finsler operator $$-{\text {div}}(B'(H(\nabla u))\nabla H(\nabla u))$$

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)

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. In particular, by means of fine regularity results on the vectorial field $$B'(H(\nabla u))\nabla H(\nabla u)$$

B
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)

∇
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, we prove the identity for weak solutions and in a direct way.