bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Immolated Nanoadjuvant for In Situ Vaccination Immunotherapy of Colorectal Cancer
Authors: Wang Weiqi , Zhu Qiwen , Jin Yilan , Gao Jing , Li Jianan , Zheng Xiaohua , Gao Weidong , Saeed Madiha , Sheng Weizhong , Yu Haijun 
Published: June 2023

AbstractVaccination immunotherapy has revolutionized cancer treatment modalities. Although the immunomodulatory adjuvant generally employs for potentiating vaccine response, systemic administration may drive immune‐related side effects, even immune tolerance. Therefore, tunable immunoadjuvants are highly desirable to simultaneously stimulate the immune response and mitigate systemic toxicity. Self‐immolated nanoadjuvants are herein reported to potentiate vaccination immunotherapy of cancer. The nanoadjuvants are engineered by co‐assembling an intracellular acidity‐ionizable polymeric agonist of toll‐like receptor 7/8 resiquimod (R848) and polymeric photosensitizer pyropheophorbide a (PPa). The resultant nanoadjuvants specifically accumulate at the tumor site via passive targeting and are dissociated in the acidic endosome versicles to activate PPa via protonation of the polymer backbone. Upon 671 nm laser irradiation, PPa performed photodynamic therapy to induce immunogenic cell death of tumor cells and subsequently releases R848 in a customized manner, which synergistically activates dendritic cells (DCs), promotes antigen cross‐presentation, and eventually recruits cytotoxic T lymphocytes for tumor regression. Furthermore, the synergistic in situ vaccination immunotherapy with immune checkpoint blockade induce sustained immunological memory to suppress tumor recurrence in the rechallenged colorectal tumor model.
Bleeding the Excited State Energy to the Utmost: Single‐Molecule Iridium Complexes for In Vivo Dual Photodynamic and Photothermal Therapy by an Infrared Low‐Power Laser
Authors: Tang Shi‐Jie , Li Qing‐Fang , Wang Meng‐Fan , Yang Rong , Zeng Li‐Zhen , Li Xue‐Lian , Wang Rui‐Dong , Zhang Hongbin , Ren Xiaoxia , Zhang Dan , Gao Feng 
Published: June 2023

AbstractA series of cyclometalated Ir(III) complexes with morpholine and piperazine groups are designed as dual photosensitizers and photothermal agents for more efficient antitumor phototherapy via infrared low‐power laser. Their ground and excited state properties, as well as the structural effect on their photophysical and biological properties, are investigated by spectroscopic, electrochemical, and quantum chemical theoretical calculations. They target mitochondria in human melanoma tumor cells and trigger apoptosis related to mitochondrial dysfunction upon irradiation. The Ir(III) complexes, particularly Ir6, demonstrate high phototherapy indexes to melanoma tumor cells and a manifest photothermal effect. Ir6, with minimal hepato‐/nephrotoxicity in vitro, significantly inhibits the growth of melanoma tumors in vivo under 808 nm laser irradiation by dual photodynamic therapy and photothermal therapy and can be efficiently eliminated from the body. These results may contribute to the development of highly efficient phototherapeutic drugs for large, deeply buried solid tumors.
Metal‐Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction
Authors: Vecchioni Simon , Lu Brandon , Livernois William , Ohayon Yoel P. , Yoder Jesse B. , Yang Chu‐Fan , Woloszyn Karol , Bernfeld William , Anantram M. P. , Canary James W. , Hendrickson Wayne A. , Rothschild Lynn J. , Mao Chengde , Wind Shalom J. , Seeman Nadrian C. , Sha Ruojie 
Published: June 2023

AbstractDNA double helices containing metal‐mediated DNA (mmDNA) base pairs are constructed from Ag+ and Hg2+ ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials is impractical without a complete lexical and structural description. Here, the programmability of structural DNA nanotechnology toward its founding mission of self‐assembling a diffraction platform for biomolecular structure determination is explored. The tensegrity triangle is employed to build a comprehensive structural library of mmDNA pairs via X‐ray diffraction and generalized design rules for mmDNA construction are elucidated. Two binding modes are uncovered: N3‐dominant, centrosymmetric pairs and major groove binders driven by 5‐position ring modifications. Energy gap calculations show additional levels in the lowest unoccupied molecular orbitals (LUMO) of mmDNA structures, rendering them attractive molecular electronic candidates.
Bioadhesives with Antimicrobial Properties
Authors: Nakipoglu Mustafa , Tezcaner Ayşen , Contag Christopher H. , Annabi Nasim , Ashammakhi Nureddin 
Published: June 2023

AbstractBioadhesives with antimicrobial properties enable easier and safer treatment of wounds as compared to the traditional methods such as suturing and stapling. Composed of natural or synthetic polymers, these bioadhesives seal wounds and facilitate healing while preventing infections through the activity of locally released antimicrobial drugs, nanocomponents, or inherently antimicrobial polers. Although many different materials and strategies are employed to develop antimicrobial bioadhesives, the design of these biomaterials necessitates a prudent approach as achieving all the required properties including optimal adhesive and cohesive properties, biocompatibility, and antimicrobial activity can be challenging. Designing antimicrobial bioadhesives with tunable physical, chemical, and biological properties will shed light on the path for future advancement of bioadhesives with antimicrobial properties. In this review, the requirements and commonly used strategies for developing bioadhesives with antimicrobial properties are discussed. In particular, different methods for their synthesis and their experimental and clinical applications on a variety of organs are reviewed. Advances in the design of bioadhesives with antimicrobial properties will pave the way for a better management of wounds to increase positive clinical outcomes.
Multistable Metafluid based Energy Harvesting and Storage
Authors: Peretz Ofek , Ben Abu Ezra , Zigelman Anna , Givli Sefi , Gat Amir D. 
Published: June 2023

AbstractThe thermodynamic properties of fluids play a crucial role in many engineering applications, particularly in the context of energy. Fluids with multistable thermodynamic properties may offer new paths for harvesting and storing energy via transitions between equilibria states. Such artificial multistable fluids can be created using the approach employed in metamaterials, which controls macro‐properties through micro‐structure composition. In this work, the dynamics of such “metafluids” is examined for a configuration of calorically‐perfect compressible gas contained within multistable elastic capsules flowing in a fluid‐filled tube. The velocity‐, pressure‐, and temperature‐fields of multistable compressible metafluids is studied by both analytically and experimentally, focusing on transitions between different equilibria. The dynamics of a single capsule is first examine, which may move or change equilibrium state, due to fluidic forces. The interaction and motion of multiple capsules within a fluid‐filled tube is then studied. It shows that such a system can be used to harvest energy from external temperature variations in either time or space. Thus, fluidic multistability allows specific quanta of energy to be captured and stored indefinitely as well as transported as a fluid, via tubes, at standard atmospheric conditions without the need for thermal isolation.
Shaping Synthetic Multicellular and Complex Multimaterial Tissues via Embedded Extrusion‐Volumetric Printing of Microgels
Authors: Ribezzi Davide , Gueye Marième , Florczak Sammy , Dusi Franziska , de Vos Dieuwke , Manente Francesca , Hierholzer Andreas , Fussenegger Martin , Caiazzo Massimiliano , Blunk Torsten , Malda Jos , Levato Riccardo 
Published: June 2023

AbstractIn living tissues, cells express their functions following complex signals from their surrounding microenvironment. Capturing both hierarchical architectures at the micro‐ and macroscale, and anisotropic cell patterning remains a major challenge in bioprinting, and a bottleneck toward creating physiologically‐relevant models. Addressing this limitation, a novel technique is introduced, termed Embedded Extrusion‐Volumetric Printing (EmVP), converging extrusion‐bioprinting and layer‐less, ultra‐fast volumetric bioprinting, allowing spatially pattern multiple inks/cell types. Light‐responsive microgels are developed for the first time as bioresins (µResins) for light‐based volumetric bioprinting, providing a microporous environment permissive for cell homing and self‐organization. Tuning the mechanical and optical properties of gelatin‐based microparticles enables their use as support bath for suspended extrusion printing, in which features containing high cell densities can be easily introduced. µResins can be sculpted within seconds with tomographic light projections into centimeter‐scale, granular hydrogel‐based, convoluted constructs. Interstitial microvoids enhanced differentiation of multiple stem/progenitor cells (vascular, mesenchymal, neural), otherwise not possible with conventional bulk hydrogels. As proof‐of‐concept, EmVP is applied to create complex synthetic biology‐inspired intercellular communication models, where adipocyte differentiation is regulated by optogenetic‐engineered pancreatic cells. Overall, EmVP offers new avenues for producing regenerative grafts with biological functionality, and for developing engineered living systems and (metabolic) disease models.
Engineering the Structural Uniformity of Gel Polymer Electrolytes via Pattern‐Guided Alignment for Durable, Safe Solid‐State Lithium Metal Batteries
Authors: Kang Qi , Zhuang Zechao , Liu Yijie , Liu Zhenhui , Li Yong , Sun Bin , Pei Fei , Zhu Han , Li Hongfei , Li Pengli , Lin Ying , Shi Kunming , Zhu Yingke , Chen Jie , Shi Chaoqun , Zhao Yan , Jiang Pingkai , Xia Yongyao , Wang Dingsheng , Huang Xingyi 
Published: June 2023

AbstractUltrathin and super‐toughness gel polymer electrolytes (GPEs) are the key enabling technology for durable, safe, and high‐energy density solid‐state lithium metal batteries (SSLMBs) but extremely challenging. However, GPEs with limited uniformity and continuity exhibit an uneven Li+ flux distribution, leading to nonuniform deposition. Herein, a fiber patterning strategy for developing and engineering ultrathin (16 µm) fibrous GPEs with high ionic conductivity (≈0.4 mS cm−1) and superior mechanical toughness (≈613%) for durable and safe SSLMBs is proposed. The special patterned structure provides fast Li+ transport channels and tailoring solvation structure of traditional LiPF6‐based carbonate electrolyte, enabling rapid ionic transfer kinetics and uniform Li+ flux, and boosting stability against Li anodes, thus realizing ultralong Li plating/stripping in the symmetrical cell over 3000 h at 1.0 mA cm−2, 1.0 mAh cm−2. Moreover, the SSLMBs with high LiFePO4 loading of 10.58 mg cm−2 deliver ultralong stable cycling life over 1570 cycles at 1.0 C with 92.5% capacity retention and excellent rate capacity of 129.8 mAh g−1 at 5.0 C with a cut‐off voltage of 4.2 V (100% depth‐of‐discharge). Patterned GPEs systems are powerful strategies for producing durable and safe SSLMBs.
Superhydrophobic Copper‐Composite Surfaces Exert Antibacterial Effects against Gram‐Negative and ‐Positive Bacteria
Authors: Mirmohammadi Seyed Mehran , Savijoki Kirsi , Hoshian Sasha , Varmanen Pekka , Yli‐Kauhaluoma Jari , Jokinen Ville , Franssila Sami 
Published: June 2023

AbstractCopper shows a high promise in developing biomedical materials with antibacterial effect. The antibacterial effect can be enhanced by nanostructured surfaces with superhydrophobic properties, which reduce the solid contact area available for bacterial adhesion and adherent growth. Here, three structured surfaces are fabricated to test the combined effect of copper and superhydrophobicity for antibacterial effects. One of the samples is superhydrophobic but does not contain copper, one contains copper but is not superhydrophobic, and the third is both superhydrophobic and contained copper. The antibiofilm and bactericidal effects of these samples are tested against medically important Gram‐positive and ‐negative bacteria including Staphylococcus aureus (S. aureus), Staphylococcus epidermidis (S. epidermidis), and Pseudomonas aeruginosa (P. aeruginosa). The findings indicate that copper alone without superhydrophobicity, while decreasing the cell viability in most of the tested species, supports remarkably more biomass compared to the reference sample. The superhydrophobic and copper bearing samples, while allowing adherent growth to take place, provide the greatest bactericidal effect against two P. aeruginosa strains, and both the antibiofilm and/or bactericidal effects against S. aureus and S. epidermidis. Thus, this study reports that nanostructured materials, combining superhydrophobicity with copper, can be the method of choice to neutralize pathogens with different cell‐wall structures and surface components mediating adherent growth.
Bottom‐Up Tunable Broadband Semi‐Reflective Chiral Mirrors
Authors: Wu Wenbing , Battie Yann , Genet Cyriaque , Ebbesen Thomas W. , Decher Gero , Pauly Matthias 
Published: June 2023

AbstractConventional mirrors flip the handedness of circularly polarized light upon reflection. However, there is an increasing demand for the design and fabrication of handedness‐preserving mirrors as well as chiral reflective metasurfaces with tunable spin states of reflected photons that work in a broad wavelength range in the UV and visible domain. Most chiral mirrors fabricated up to now are prepared by top‐down techniques, such as e‐beam lithography, which are very costly and difficult to scale up to macroscopic devices. Here, an efficient bottom‐up strategy is introduced for fabricating chiral mirrors by using Layer‐by‐Layer assembly of oriented silver nanowire layers prepared by grazing incidence spraying on a semi‐reflective silver layer. The resulting chiral metasurfaces display structure‐dependent differential reflectance for circularly polarized light in a broad wavelength range in the UV, visible, and near infrared domains, reaching an extremely high figure of merit. Their differential reflectance reaches up to 95% of the maximum polarization efficiency, with the handedness of the reflected light being partially preserved. These large‐area chiral mirrors with tunable chiral reflectance open perspectives in various fields, such as in optics, sensing, and chiral light‐matter interactions.
Paths towards a healthier BMI among short and adequate sleepers: A pathway network analysis considering movement behaviors in low‐income preschoolers
Authors: de Souza Alesandra Araújo , Bandeira Paulo Felipe Ribeiro , Vale Susana Maria Coelho Guimarães , da Cunha Glacithane Lins , Mota Jorge Augusto Pinto Silva , de Lucena Martins Clarice Maria 
Published: June 2023

AbstractIntroductionShort sleep duration has been seen as a predictor of higher body mass index (BMI) in youth. Sleep duration varies substantially along early childhood, and the paths towards a healthier BMI, considering the other movement behaviors (physical activity‐PA and screen time) are unexplored in preschoolers.AimTo construct a sleep‐BMI model to capture the direct and indirect paths to intervening towards a healthier BMI, according to low‐income preschoolers' compliance with the other movement behaviors.MethodsTwo hundred and seventy two preschoolers (4.5 ± 0.0; 138 boys) participated in the study. Sleep and screen time (ST) were assessed in a face‐to‐face interview with primary caregivers. PA was assessed using accelerometer (wGT3X‐BT). Preschoolers were categorized as compliant or not with sleep, screen time, total and moderate to vigorous PA recommendations. BMIz‐score was calculated according to preschoolers' sex and age. All the assessed variables, besides sex and age were included in a Network Pathway Analysis (NPA) according to age as nodes.ResultsAt 3 years old, a direct and negative path between sleep‐BMIz score was observed. At four and 5 years old, this relationship became positive. Further, girls were more compliant with sleep, ST and total PA recommendations. Total PA (TPA) showed the highest expected influence value in the general, 3 and 4 years old NPA.ConclusionThe NPA analysis showed different directions for the relationship between sleep and BMIz score, according to age. Intervention strategies to a healthier BMI among preschoolers compliant or not with sleep recommendations should focus in increasing TPA.
Synthesis of Hybrid Isoxazole‐triazole Compounds as Potential Antiproliferative Agents
Authors: Karetnikov Georgy L. , Skvortsov Dmitry A. , Moseicheva Anastasiia A. , Zyk Nikolay V. , Bondarenko Oksana B. 
Published: June 2023

AbstractAn efficient route for the synthesis of a series of new hybrid isoxazole‐triazole compounds in high yields and excellent regioselectivity starting from either 2‐aryl‐1,1‐dichlorocyclopropanes or N‐hydroxybenzimidoyl chlorides was developed. The synthesized isoxazole‐triazole hybrids were evaluated for their biological activity.
Synthesis of Dihydropyrazoles by Pd‐Catalyzed Carboamination of Alkenyl Hydrazones with Aryl Triflates
Authors: Gao Min , Wang Yinqiang , Wu Shuaijie , Ni Feier , Hu Cangzhu , Jin Feifei , Sun Jing , Han Ying , Wang Lei 
Published: June 2023

AbstractHerein, we presented a novel and highly efficient strategy for the synthesis of dihydropyrazoles via Pd‐catalyzed carboamination reaction of alkenyl hydrazones with aryl triflates. The simultaneous formation of C−C and C−N bonds in one step is particularly appealing. This methodology provides a practical and efficient avenue of the synthesis of diversely aryl substituted dihydropyrazoles in good yields.
Rhodium‐Catalyzed C−H Alkylation for the Stereoselective Synthesis of β,β‐Disubstituted Dehydroamino‐Acid Motifs
Authors: Nanjo Takeshi , Sada Hikari , Nagaya Taisei , Maruo Yuri , Takemoto Yoshiji 
Published: June 2023

AbstractIn this article, we describe the stereoselective formation of β,β‐disubstituted dehydroamino acids (ΔAAs) in peptides using a cationic rhodium catalyst and methyl trifluoroborate salt. Using this approach, an alkyl group was directly installed on a β‐monosubstituted ΔAA in the peptide chain and both isomers of dehydroisoleucine, an important yet usually inaccessible ΔAA, were successfully obtained.
B7Be6B7: A Boron‐Beryllium Sandwich Complex
Authors: Dong Xue , Tiznado William , Liu Yu‐qian , Leyva‐Parra Luis , Liu Xin‐bo , Pan Sudip , Merino Gabriel , Cui Zhong‐hua 
Published: June 2023

AbstractPlanar boron clusters have often been regarded as “π‐analogous” to aromatic arenes because of their similar delocalized π‐bonding. However, unlike arenes such as C5H5− and C6H6, boron clusters have not previously shown the ability to form sandwich complexes. In this study, we present the first sandwich complex involving beryllium and boron, B7Be6B7. The global minimum of this combination adopts a unique architecture having a D6h geometry, featuring an unprecedented monocyclic Be6 ring sandwiched between two quasi‐planar B7 motifs. The thermochemical and kinetic stability of B7Be6B7 can be attributed to strong electrostatic and covalent interactions between the fragments. Chemical bonding analysis shows that B7Be6B7 can be considered as a [B7]3−[Be6]6+[B7]3− complex. Moreover, there is a significant electron delocalization within this cluster, supported by the local diatropic contributions of the B7 and Be6 fragments.
Naphth[4]arene: Synthesis, Conformations, and Application in Color‐Tunable Supramolecular Crystalline Assemblies
Authors: Gu Meng‐Jie , Han Xiao‐Ni , Guo Wei‐Chen , Han Ying , Chen Chuan‐Feng 
Published: June 2023

AbstractAlthough the chemistry of macrocyclic arenes has seen rapid development in recent years, the synthesis of new macrocyclic arenes from aromatic rings with no directing groups remains a challenge. In this work, a new macrocyclic arene, naphth[4]arene (NA[4]A), composed of four naphthalene rings bridged by methylene groups, was synthesized using macrocycle‐to‐macrocycle conversion. NA[4]A shows 1,3‐alternate and 1,2‐alternate conformations in the solid state, which can be selectively obtained. By supramolecular co‐assembly of NA[4]A and 1,2,4,5‐tetracyanobenzene (TCNB) in different concentrations and temperatures, two conformation‐dependent crystalline luminescent co‐assemblies 1,2‐NTC and 1,3‐NTC can be selectively prepared. Interestingly, the two charge‐transfer crystalline assemblies containing NA[4]A with different conformations show bright yellow and green fluorescence, and also display high photoluminescence quantum yields (PLQYs) of 45 % and 43 %. Furthermore, they exhibit color‐tunable two‐photon excited upconversion emission.
What is the “modified” CTAB protocol? Characterizing modifications to the CTAB DNA extraction protocol
Authors: Schenk John J. , Becklund L. Ellie , Carey S. James , Fabre Paige P. 
Published: June 2023

AbstractCetyltrimethylammonium bromide (CTAB)–based methods are widely used to isolate DNA from plant tissues, but the unique chemical composition of secondary metabolites among plant species has necessitated optimization. Research articles often cite a “modified” CTAB protocol without explicitly stating how the protocol had been altered, creating non‐reproducible studies. Furthermore, the various modifications that have been applied to the CTAB protocol have not been rigorously reviewed and doing so could reveal optimization strategies across study systems. We surveyed the literature for modified CTAB protocols used for the isolation of plant DNA. We found that every stage of the CTAB protocol has been modified, and we summarized those modifications to provide recommendations for extraction optimization. Future genomic studies will rely on optimized CTAB protocols. Our review of the modifications that have been used, as well as the protocols we provide here, could better standardize DNA extractions, allowing for repeatable and transparent studies.
Tunable Quantum Anomalous Hall Gap in Compressed Graphene/CrI3 van der Waals Heterostructures
Authors: Ren Jun‐Tong , Feng Yuan , Ke Sha‐Sha , Lü Hai‐Feng 
Published: June 2023

AbstractTwo‐dimensional magnetic heterostructures have attracted special attention due to their potential applications in fundamental physics and spintronics. Here, the magnetic and electronic properties of the van der Waals heterostructure formed by graphene and CrI3 is investigated. The first‐principles calculations show that the spin‐polarized electron density of graphene sensitively depends on the charge transfer between graphene and CrI3, which can be modulated by applying an electric field. However, the spin‐polarized density exhibits a non‐monotonic change with electric field due to the unstable charge distribution between graphene and CrI3. When the interface distance is compressed by 1.1 Å, the enhanced interaction between graphene and CrI3 stabilizes the charge distribution. As a result, the quantum anomalous Hall gap increases from 6 to 22 meV with an external electric field in the compressed heterostructure. In addition, halogen ligands play an important role in the interaction between Cr atoms and graphene and can regulate the range of spin‐polarized density.
Polycyclic Aromatic Hydrocarbon‐based Soft Materials: Applications in Fluorescent Detection, Gelation, AIEE and Mechanochromism
Authors: Goyal Hina , Kumar Pramod , Gupta Rajeev 
Published: June 2023

AbstractThe present review discusses selected compounds based on polycyclic aromatic hydrocarbons (PAHs); mainly those containing naphthalene, anthracene, fluorene, pyrene, triphenylene and perylene rings. The focus has been placed to highlight both properties and applications of such PAH‐containing compounds in gelation, aggregation‐induced enhanced emission (AIEE) and mechanochromism as well as in fluorescence sensing of assorted analytes.