bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study design for development of novel safety biomarkers of drug-induced liver injury by the translational safety biomarker pipeline (TransBioLine) consortium: a study protocol for a nested case–control study
Authors: Grove Jane I. , Stephens Camilla , Lucena M. Isabel , Andrade Raúl J. , Weber Sabine , Gerbes Alexander , Bjornsson Einar S. , Stirnimann Guido , Daly Ann K. , Hackl Matthias , Khamina-Kotisch Kseniya , Marin Jose J. G. , Monte Maria J. , Paciga Sara A. , Lingaya Melanie , Forootan Shiva S. , Goldring Christopher E. P. , Poetz Oliver , Lombaard Rudolf , Stege Alexandra , Bjorrnsson Helgi K. , Robles-Diaz Mercedes , Li Dingzhou , Tran Thi Dong Binh , Ramaiah Shashi K. , Samodelov Sophia L. , Kullak-Ublick Gerd A. , Aithal Guruprasad P. ,   on behalf of the TransBioLine consortium
Published: September 2023

AbstractA lack of biomarkers that detect drug-induced liver injury (DILI) accurately continues to hinder early- and late-stage drug development and remains a challenge in clinical practice. The Innovative Medicines Initiative’s TransBioLine consortium comprising academic and industry partners is developing a prospective repository of deeply phenotyped cases and controls with biological samples during liver injury progression to facilitate biomarker discovery, evaluation, validation and qualification.In a nested case–control design, patients who meet one of these criteria, alanine transaminase (ALT) ≥ 5 × the upper limit of normal (ULN), alkaline phosphatase ≥ 2 × ULN or ALT ≥ 3 ULN with total bilirubin > 2 × ULN, are enrolled. After completed clinical investigations, Roussel Uclaf Causality Assessment and expert panel review are used to adjudicate episodes as DILI or alternative liver diseases (acute non-DILI controls). Two blood samples are taken: at recruitment and follow-up. Sample size is as follows: 300 cases of DILI and 130 acute non-DILI controls. Additional cross-sectional cohorts (1 visit) are as follows: Healthy volunteers (n = 120), controls with chronic alcohol-related or non-alcoholic fatty liver disease (n = 100 each) and patients with psoriasis or rheumatoid arthritis (n = 100, 50 treated with methotrexate) are enrolled. Candidate biomarkers prioritised for evaluation include osteopontin, glutamate dehydrogenase, cytokeratin-18 (full length and caspase cleaved), macrophage-colony-stimulating factor 1 receptor and high mobility group protein B1 as well as bile acids, sphingolipids and microRNAs. The TransBioLine project is enabling biomarker discovery and validation that could improve detection, diagnostic accuracy and prognostication of DILI in premarketing clinical trials and for clinical healthcare application.
Spreadsheet Simulation of Priority Queues
Authors: Leong Thin-Yin , Ma Nang-Laik 
Published: September 2023

This paper develops a spreadsheet simulation methodology for teaching simulation and performance analysis of priority queues with multiple servers, without resorting to macros, add-ins, or array formula. The approach is made possible by a “single overtaking” simplifying assumption under which any lower-priority customer may be passed in line by at most one higher-priority customer. By increasing the number of overtaking customers, one at a time, the simulation model is extended to the “multiovertaking” case. These simplifying assumptions make such spreadsheet simulations (of more complex queuing networks) accessible to students, and so the paper includes teaching and learning strategies for the classroom. Performance analysis of single-overtaking versus multiovertaking polices is included. Supplemental Material: The online data is available at https://doi.org/10.1287/ited.2022.0037 .
Acceptance and understanding of artificial intelligence in medical research among orthopaedic surgeons
Authors: Ormond Michael J. , Clement Nick D. , Harder Ben G. , Farrow Luke , Glester Andrew 
Published: September 2023

AimsThe principles of evidence-based medicine (EBM) are the foundation of modern medical practice. Surgeons are familiar with the commonly used statistical techniques to test hypotheses, summarize findings, and provide answers within a specified range of probability. Based on this knowledge, they are able to critically evaluate research before deciding whether or not to adopt the findings into practice. Recently, there has been an increased use of artificial intelligence (AI) to analyze information and derive findings in orthopaedic research. These techniques use a set of statistical tools that are increasingly complex and may be unfamiliar to the orthopaedic surgeon. It is unclear if this shift towards less familiar techniques is widely accepted in the orthopaedic community. This study aimed to provide an exploration of understanding and acceptance of AI use in research among orthopaedic surgeons.MethodsSemi-structured in-depth interviews were carried out on a sample of 12 orthopaedic surgeons. Inductive thematic analysis was used to identify key themes.ResultsThe four intersecting themes identified were: 1) validity in traditional research, 2) confusion around the definition of AI, 3) an inability to validate AI research, and 4) cautious optimism about AI research. Underpinning these themes is the notion of a validity heuristic that is strongly rooted in traditional research teaching and embedded in medical and surgical training.ConclusionResearch involving AI sometimes challenges the accepted traditional evidence-based framework. This can give rise to confusion among orthopaedic surgeons, who may be unable to confidently validate findings. In our study, the impact of this was mediated by cautious optimism based on an ingrained validity heuristic that orthopaedic surgeons develop through their medical training. Adding to this, the integration of AI into everyday life works to reduce suspicion and aid acceptance.Cite this article: Bone Jt Open 2023;4(9):696–703.
SDS-PAGE protein profile of albumin extracted by steaming from four marine and three brackish-water fishes
Authors: FATMA NUR , METUSALACH METUSALACH , TASLIM NURPUDJI ASTUTI , NURILMALA MALA 
Published: September 2023

Abstract. Fatma N, Metusalach, Taslim NA, Nurilmala M. 2023. SDS-PAGE protein profile of albumin extracted by steaming from four marine and three brackish-water fishes. Biodiversitas 24: 4027-4033. Snakehead fish is a type of fish that has been known as the best source of fish albumin. However, the increasing demand for and exploitation of snakehead fish albumin is not accompanied by the availability of sustainable snakehead fish stocks. Snakehead fish stocks in nature continue to experience depletion and cultivation efforts that have been carried out so far have not yielded satisfactory results. For this reason, it is necessary to find alternative sources of fish albumin. The purpose of this study was to determine the molecular weight of the albumin proteins extracted by water bath steaming from four marine fishes (Indian scad Decapterus russelli, short-bodied mackerel Rastrelliger brachysoma, goldband fusilier Pterocaesio chrysozona, Japanese threadfin bream Nemipterus japonicus) and three brackish-water fishes (white-lipped eel catfish Paraplotosus albilabris, barramundi Lates calcarifer, milkfish Chanos chanos). The method used was Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE) electrophoresis. Each sample was steamed in a water bath at 50°C for 30 minutes to obtain the crude extract's optimal yield and albumin content. The molecular weights of each protein band were analyzed using the Photocapt application, visualized and tabulated, and analyzed descriptively. Indian scad had six protein bands with three major (48 kD, 37 kD, 32 kD) and three minor bands (66 kD, 25 kD, 15 kD). Shortbodied mackerel had one major protein band (26 kD). Goldband fusilier had one major (33 kD) and four minor bands (50 kD, 69 kD, 57 kD, 26 kD). Japanese threadfin bream had one major (62 kD) and three minor bands (171 kD, 72 kD, 26 kD). White-lipped eel catfish had two major (41 kD, 34 kD and two minor bands (70 kD, 26 kD). Barramundi had one major (26 kD) and two minor bands (171 kD, 87 kD). Milkfish had one major (41 kD) and four minor bands (333 kD, 135 kD, 31 kD, 25 kD). It is hoped that this research will provide information on which fish have the potential as a source of fish albumin in terms of protein composition which resembles snakehead fish so that the properties provided are as good as albumin from snakehead fish.
Molecular evaluation of genetic diversity and relationships of Musa cultivars in Thailand using Start Codon Targeted (SCoT) markers
Authors: NITIWORAKARN SARUDA , PHAE-NGAM WUTTICHAI , VANIJAJIVA ONGKARN 
Published: September 2023

Abstract. Nitiworakarn S, Phae-Ngam W, Vanijajiva O. 2023. Molecular evaluation of genetic diversity and relationships of Musa cultivars in Thailand using Start Codon Targeted (SCoT) markers. Biodiversitas 24: 4060-4068. Musa cultivars are mostly obtained from crossing between wild diploid subspecies of M. acuminata (A genome) and M. balbisiana (B genome), and they reveal numerous levels of ploidy and genomic constitution. The present study, for the first time, investigated the genetic diversity of 90 Musa cultivars from 17 localities of Chai Badan district in Lopburi Province, Thailand, using start codon targeted (SCoT) markers. The SCoT technique has shown very high repeatability for characterizing Musa cultivars. The result indicated that DNA fingerprints from 30 SCoT primers generated 244 amplicons, among which 238 bands (97.54%) were polymorphic, with a mean of 7.93 polymorphic bands per primer. The average polymorphism information content (PIC) was high, ranging from 0.345 to 0.483, with an average of 0.432. Genetic diversity and its partitioning parameters were calculated and demonstrated that present Musa cultivars maintain relatively high genetic diversity. The unweighted pair-group method with an arithmetic cluster analysis, principal coordinate analysis and STRUCTURE analysis results were the same and showed the clear division of the genotypes into two distinct clusters, which were cluster-I consisted of only the AA genomes and cluster-II comprised of ABB and BB genomes. In conclusion, SCoT markers obtained here showed their manipulation in genetic diversity and the relationship of cultivated Musa, which would be practical for genetic preservation and continuing breeding programs in Thailand and other regions.
Genetic profiling of locally registered Philippine coffee using molecular markers linked to resistance against diseases and pests
Authors: SANTOS NICK RAINIER S. , MAGAT MONALIZA B. , MONDRAGON MIGUEL V. , CAO ERNELEA P. , SANTOS DAISY MAY C. 
Published: September 2023

Abstract. Santos NRS, Magat MB, Mondragon MV, Cao EP, Santos DMC. 2023. Genetic profiling of locally registered Philippine coffee using molecular markers linked to resistance against diseases and pests. Biodiversitas 24: 4136-4144. Coffee is a major commodity in the Philippines, but diseases and pests have hampered local production. Natural resistance could help increase production by eradicating infestation or lessening the symptoms of infection and minimizing the need for chemical control. Hence, this study aims to screen local Coffea arabica varieties, whose beans are prized for their superior taste and aroma, using genetic markers. These markers are linked to resistance against Coffee Leaf Rust (CLR, caused
by Hemileia vastatrix), Coffee Berry Disease (CBD, caused by Colletotrichum kahawae), and Root Knot Nematode (RKN, Meloidogynespp.). The Arabica samples were obtained from the Bureau of Plant Industry in Baguio City, Benguet, a main distributor of coffee seedlings to farmers. C. canephora and C. liberica trees from Cavite State University, Indang, Cavite, were used as control samples. Results reveal that the registered NSIC-2008-Cf-A-05 (Red Bourbon) Arabica tree contains a unique haplotype in a region of chromosome 3. This region has been linked to the SH3 gene, which confers resistance against CLR, a promising result for infested areas. However, all Arabica samples are inferred to be susceptible to CBD and RKN. Hence, NSIC-2008-Cf-A-05 is a potential source for resistance genes specifically against CLR in future breeding programs.
Polymorphic analysis of the OsHKT1;5 exon 1 gene region on seasonal rice varieties with salt tolerant capacity
Authors: NGUYEN THI PHA , LA HOANG TRUC NGAN , DO TAN KHANG , TRAN DINH GIOI 
Published: September 2023

Abstract. Nguyen TP, La HTG, Do TK, Tran DG. 2023. Polymorphic analysis of theOsHKT1;5exon 1 gene region on seasonal rice varieties with salt tolerant capacity. Biodiversitas 24: 4159-4165. In recent years, saline intrusion has caused serious damage to agricultural production in the Mekong Delta; therefore, research on salinity-tolerant rice varieties is necessary. This study was carried out to screen the salt tolerance capacity of 38 seasonal rice varieties in four concentrations of NaCl supplements, including 4‰, 6‰, 8‰, and 10‰ in comparison with IR28 and Pokkali checks according to IRRI (2021) methods. Eight rice cultivars in four levels of salinity tolerance (two varieties of each level) were selected to evaluate the nucleotide sequence polymorphism in the coding region of OsHKT1;5exon 1, comparedwith that of IR28 and Pokkali checkcultivars and Nipponbare referential variety. The results of salt tolerance screening showed that the salt concentration and the rate of reduction of plant height and root length were positively correlated. Nucleotide sequence polymorphism analysis of OsHKT1;5exon 1 indicated six nucleotide substitutions (SNP) at positions 382, 418, 551, 994, 1119, and 1152. Further analysis revealed thatfive SNPs were detected withthree missense mutations (P60A, R63H, and H255D) in salt tolerant check variety (Pokkali), three to four SNPs with one to two missense mutations H255D or P60A and H255D were observed in salt moderate tolerant varieties, while salt-sensitive varieties and sensitive check variety IR28 were observed with two SNPs and one missense mutation (H255D).
The Impact of Russia-Ukraine Conflict on Global Commodity Brent Crude Prices
Authors: PAL HEMENDRA 
Published: September 2023

This study investigates the impact of the Russia- Ukraine conflict on Brent Crude commodity pricing using World Bank time series data. The conflict’s influence on global oil and gas markets, characterized by intricate supply and demand dynamics, is analyzed through advanced time series techniques and machine learning modeling. Univariate models such as AutoCorrelation Function (ACF) and Partial AutoCorrelation Function (PACF) are employed to discern temporal patterns in Brent Crude prices. Additionally, Seasonal Autoregressive Inte- grated Moving Average (SARIMA) and Exponential Smoothing State Space (ETS) models are utilized to capture complex seasonality and trends in the data.
Moving beyond traditional methods, multivari ate models are leveraged to comprehensively grasp the multifaceted impact of the conflict. Principal Component Analysis (PCA) and Factor Analysis are applied to uncover latent variables influencing Brent Crude pricing in the context of global trade disruptions, inflation, and diplomatic negotiations. These extracted components are then integrated with ensemble machine learning algorithms, including Random Forest, Extra Tree Classifier, Gradient Boosting, K-Nearest Neighbors, and Decision Trees. The fusion of multivariate time series analysis and machine learning empowers a holistic understanding of the conflict’s intricate repercussions on commodity prices.
Through a comprehensive exploration of time series data and advanced machine learning modeling, this research contributes to a deeper understanding of the intricate relationship between the Russia-Ukraine conflict and global commodity pricing. The findings offer valuable insights for policymakers, industry stakeholders, and investors seeking to navigate the complex landscape of commodity markets during periods of geopolitical instability.
Peran Notaris Sebagai Pejabat Umum Dalam Era Revolusi Industri 4.0
Authors: Mirna Talita Dista Vennesya , Ratna Edith 
Published: September 2023

AbstractA notary is a public official who has the authority to make an authentic. Notaries have an obligation to keep up with the times that have a relationship with the notary. The era of the Industrial Revolution 4.0 was the beginning of the merger between automation technology and cyber technology. The purpose of this study is to determine the role of the notary as a general official in the era of the industrial revolution 4.0 and the responsibility of the notary as a general official in the era of the industrial revolution 4.0. The research method used is normative juridical. The results of this study were found that the role of the notary in providing support for government regulations to serve the process of licensing integrity with electronic (OSS), efforts to arrange business entities according to KBLI until the business entity has NIB. It is expected that the notary in the era of the Industrial Revolution 4.0 can be open to digitalization but without ignoring the duties and obligations of the Notary. The notary is responsible for the formal form of authentic deed in accordance with the law and must be careful so that there is no legal flaw. Keyword: notary; notary role; industry revolution 4.0AbstrakNotaris ialah pejabat umum yang memiliki wewenang dalam pembuatan akta otentik. Notaris memiliki kewajiban untuk mengikuti perkembangan zaman yang memiliki keterkaitan mengenai hubungan yang terkait dengan Notaris. Era Revolusi Industri 4.0 merupakan awal dari penggabungan antara teknologi otomatisasi dengan teknologi siber. Tujuan penelitian ini untuk mengetahui peran Notaris sebagai pejabat umum di era Revolusi Industri 4.0 dan tanggung jawab Notaris sebagai pejabat umum dalam era Revolusi Industri 4.0. Metode penelitian yang digunakan adalah Yuridis Normatif. Hasil penelitian ini didapatkan bahwa peran Notaris dalam memberi dukungan peraturan pemerintah untuk melayani proses perizinan terintegritasi dengan elektronik (OSS), upaya penataan badan usaha menurut KBLI hingga badan usaha tersebut memiliki NIB. Diharapkan notaris dalam era Revolusi Industri 4.0 ini dapat terbuka terhadap digitalisasi namun tanpa mengesampingkan tugas dan kewajiban Profesi Notaris. Notaris bertanggung jawab pada bentuk formal akta otentik sesuai undang-undang dan harus hati-hati agar tak ada cacat hukum.Kata kunci: notaris, peran notaris, revolusi industry 4.0
Hak Anak Akibat Perceraian Berdasarkan Undang-Undang Perkawinan Dan Kompilasi Hukum Islam
Authors: Triyanita Luluk Septaniar , Prananingtyas Paramita 
Published: September 2023

AbstractAnalyzing children's rights after parents' divorce and the legal consequences for parents who are less responsible for caring for children, based on Law Number 16/2019 concerning Amendments to Law Number 1/1974 concerning Marriage and Compilation of Islamic Law. This study aims to analyze the perspective of Law No. 16/2019 concerning Amendments to Law No. 1/1974 and the Compilation of Islamic Law related to fulfilling child custody after divorce, as well as analyzing the legal consequences for divorced parents based on this Law for negligence in fulfilling children's rights. The research method used is normative juridical. The results of the study concluded that Law No. 16/2019 concerning Amendments to Law No. 1/1974 clearly pays attention to fulfilling a number of children's rights properly, both in situations of intact husband and wife relationships and after divorce. There are consequences for parents who are negligent in the hadhanah obligation, with the implication of revoking the parent's control rights over the child. Keyword: due to divorce; children's rights; hadhanahAbstrakMenganalisis hak anak setelah perceraian orang tua dan konsekuensi hukum bagi orang tua yang kurang bertanggung jawab dalam pemeliharaan anak, berdasarkan Undang-Undang Nomor 16/2019 tentang Perubahan Atas Undang Nomor 1/1974 tentang Perkawinan dan Kompilasi Hukum Islam. Penelitian ini bertujuan menganalisis perspektif UU No 16/2019 tentang Perubahan Atas UU No 1/1974 dan Kompilasi Hukum Islam terkait pemenuhan hak asuh anak setelah perceraian, serta menganalisis konsekuensi hukum bagi orang tua yang bercerai berdasarkan UU tersebut terhadap kelalaian dalam pemenuhan hak anak. Metode penelitian yang dipergunakan yakni yuridis normatif. Hasil penelitian menyimpulkan bahwa UU No 16/2019 tentang Perubahan Atas UU No 1/1974 dengan jelas memperhatikan pemenuhan sejumlah hak anak dengan baik, baik dalam situasi hubungan suami istri yang utuh maupun setelah bercerai. Terdapat konsekuensi bagi orang tua yang lalai dalam kewajiban hadhanah, dengan implikasi pencabutan hak penguasaan orang tua terhadap anak tersebut.Kata kunci: akibat perceraian; hak anak; hadhanah
Penerapan Sistem Profit Pada Pembiayaan KPR Subsidi Di BTN Syariah Kota Semarang
Authors: Nur Chalizah Fira Adelia , Silviana Ana 
Published: September 2023

AbstractDecree of the Minister of Public Works and Public Housing No. 242/KPTS/M/2020 sets the interest rate/margin in KPR subsidized financing at 5%, BTN Syariah as the implementing bank also complies with this. The problem that arises is how to use the interest system for subsidized mortgage financing at the BTN Syariah Semarang City and whether the subsidized mortgage financing is in accordance with Islamic law. This study aims to provide an explanation of the interest system in Islamic banks in mortgage financing. This study uses a Social Legal approach with a descriptive analytical research specification. The results obtained from this study are that BTN Syariah does not use an interest system in its financing, the profits obtained are only based on margins and subsidized mortgages at BTN Syariah have been based on the DSN MUI fatwa and are declared permissible to be implemented.Keywords: financing; KPR subsidy; BTN syariahAbstrakKeputusan Menteri Pekerjaan Umum dan Perumahan Rakyat No. 242/KPTS/M/2020 menetapkan suku bunga/marjin dalam pembiayaan KPR Subsidi sebesar 5%, BTN Syariah sebagai bank pelaksana juga mematuhi hal tersebut. Permasalahan yang timbul adalah bagaimana penggunaan sistem bunga pada pembiayaan KPR Subsidi di BTN Syariah Kantor Cabang Kota Semarang dan apakah pembiayaan KPR Subsidi sudah sesuai dengan syariat Islam. Penelitian ini bertujuan memberikan penjelasan mengenai sistem bunga pada bank syariah dalam pembiayaan KPR. Penelitian ini menggunakan metode pendekatan Social Legal dengan spesifikasi penelitian bersifat deskriptif analitis. Hasil yang diperoleh dari penelitian ini adalah BTN Syariah tidak menggunakan sistem bunga pada pembiayaannya, keuntungan yang diperoleh hanya berdasarkan marjin dan KPR subsidi pada BTN Syariah telah berdasarkan fatwa DSN MUI dan dinyatakan diperbolehkan untuk dilaksanakan.Kata kunci: pembiayaan; KPR subsidi; BTN syariah