bluuebunny/crossref_metadata_2025_split huggingface dataset:
BPIFB1 promotes metastasis of hormone receptor‐positive breast cancer via inducing macrophage M2‐like polarization
Authors: Hu Anbang , Liu Yansong , Zhang Hanyu , Wang Ting , Zhang Jiarui , Cheng Weilun , Yu Tianshui , Duan Yunqiang , Feng Jianyuan , Chen Ziang , Ding Yu , Li Yanling , Li Mingcui , Rong Zhiyuan , Shang Yuhang , Shakila Suborna S. , Zou Yiyun , Ma Fei , Guo Baoliang 
Published: September 2023

AbstractMetastasis is an important factor affecting the prognosis of hormone receptor‐positive breast cancer (BC). However, the molecular basis for migration and invasion of tumor cells remains poorly understood. Here, we identify that bactericidal/permeability‐increasing‐fold‐containing family B member 1 (BPIFB1), which plays an important role in innate immunity, is significantly elevated in breast cancer and associated with lymph node metastasis. High expression of BPIFB1 and its coding mRNA are significantly associated with poor prognosis of hormone receptor‐positive BC. Using enrichment analysis and constructing immune infiltration evaluation, we predict the potential ability of BPIFB1 to promote macrophage M2 polarization. Finally, we demonstrate that BPIFB1 promotes the metastasis of hormone receptor‐positive BC by stimulating the M2‐like polarization of macrophages via the establishment of BC tumor cells/THP1 co‐culture system, qPCR, Transwell assay, and animal experiments. To our knowledge, this is the first report on the role of BPIFB1 as a tumor promoter by activating the macrophage M2 polarization in hormone receptor‐positive breast carcinoma. Together, these results provide novel insights into the mechanism of BPIFB1 in BC.
Lamb–Shaffer syndrome: 20 Spanish patients and literature review expands the view of neurodevelopmental disorders caused by SOX5 haploinsufficiency
Authors: Tenorio‐Castano Jair , Gómez Ángela Sánchez‐Algaba , Coronado Mónica , Rodríguez‐Martín Pilar , Parra Alejandro , Pascual Patricia , Cazalla Mario , Gallego Natalia , Arias Pedro , Morales Aixa V. , Nevado Julián , Lapunzina Pablo 
Published: September 2023

AbstractLamb–Shaffer Syndrome (LSS; OMIM #616803; ORPHA #313892; ORPHA #313884) is an infrequent genetic disorder that affects multiple aspects of human development especially those related to the development of the nervous system. LSS is caused by variants in the SOX5 gene. At the molecular level, SOX5 gene encodes for a transcription factor containing a High Mobility Group (HMG) DNA‐Binding domain with relevant functions in brain development in different vertebrate species. Clinical features of Lamb–Shaffer syndrome may include intellectual disability, delayed speech and language development, attention deficits, hyperactivity, autism spectrum disorder, visual problems and seizures. Additionally, patients with the syndrome may present distinct facial dimorphism such as a wide mouth with full lips, small chin, broad nasal bridge, and deep‐set eyes. Other physical features that have been reported in some patients include short stature, scoliosis, and joint hypermobility. Here, we report the clinical and molecular characterization of a Spanish LSS cohort of new 20 patients and review all the patients published so far which amount for 111 patients. The most frequent features included developmental delay, intellectual disability, visual problems, poor speech development and facial dysmorphic features. Strikingly, pain insensitivity and hypermetropia seems to be more frequent than previously reported, based on the frequency seen in the Spanish cohort. Eighty‐three variants have been reported so far, single nucleotide variants (SNV) and copy number variants represent 47% and 53%, respectively, from the total of variants reported. Similarly to previous reports, the majority of the SNVs variants of the novel patients reported herein fall in the HMG domain of the protein. However, new variants, affecting other functional domains, were also detected. In conclusion, LLS is a rare genetic disorder mostly characterized by a wide range of developmental and neurological symptoms. Early diagnosis would allow to start of care programs, clinical follow up, prospective studies and appropriate genetic counseling, to promote clinical and social improvement to have profound lifelong benefits for patients and their families. Further research is needed to better understand the underlying mechanisms of the syndrome related to SOX5 haploinsufficiency.
Localized calcium oxalate crystals in primary cutaneous aspergillosis
Authors: Meyer Summer N. , Le Stephanie , Caro‐Chang Leah Antoinette , Awasthi Smita , Fung Maxwell A. , Kiuru Maija 
Published: September 2023

AbstractSelect Aspergillus species can produce oxalate as a fermentation byproduct, which may react with calcium ions to produce insoluble calcium oxalate crystals in tissues. These crystals are frequently associated with pulmonary Aspergillus infections, yet are rarely described in primary cutaneous aspergillosis. Herein, we report the presence of calcium oxalate crystals detected on cutaneous specimens from primary cutaneous Aspergillus niger and Aspergillus fumigatus infections in an immunocompromised, premature infant. No metabolic sources of oxalosis were found.
Aktuelle Situation der allergologischen Versorgung an deutschen Kliniken
Authors: Hollstein Moritz Maximilian , Schober Anna , Treudler Regina , Becker Sven , Epping Jelena , Hamelmann Eckard , Taube Christian , Wagenmann Martin , Wedi Bettina , Worm Margitta , Zink Alexander , Buhl Timo , Werfel Thomas , Traidl Stephan 
Published: September 2023

ZusammenfassungHintergrundDie Allergologie ist in Deutschland interdisziplinär organisiert. Zur Steuerung und Verbesserung fachbereichsübergreifender Kooperationen ist ein Überblick über die aktuelle Versorgungssituation notwendig.MethodeZwischen Januar und Februar 2022 wurden online und postalisch Fragebögen an Leitungen stationärer klinischer Fachbereiche versendet, denen die meisten allergologischen Krankheitsbilder zugeordnet werden (Dermatologie, HNO, Pneumologie, Pädiatrie, Umwelt/Arbeitsmedizin, Gastroenterologie; n = 899).ErgebnisseDie Rücklaufquote betrug 52,1%. Allergologische Abteilungen von Dermatologie, HNO und Pneumologie waren überwiegend in Ballungsgebieten verfügbar (> 100 000 Einwohner), während Antworten pädiatrischer Abteilungen größtenteils aus kleinen Städten kamen. 76,8% der befragten Kliniken gaben bestehende interdisziplinäre Behandlungskonzepte mit anderen Fachrichtungen an. Kliniken der Pädiatrie und der Pneumologie vermeldeten, insbesondere in kleineren Städten mit < 100 000 Einwohnern, unterproportional wenig interdisziplinäre Behandlungskonzepte mit Dermatologie und HNO‐Kliniken. Diagnostik und Therapie der allergischen Rhinitis wurden insbesondere durch die Abteilungen für HNO und Asthma vor allem durch die Abteilungen für Pneumologie durchgeführt. Die Betreuung der weiteren allergologischen Erkrankungen wurde am häufigsten aus der Dermatologie und Pädiatrie zurückgemeldet.SchlussfolgerungenIn Ballungsgebieten übernehmen beteiligte Fachbereiche die allergologische Versorgung kooperativ. Ein großes Spektrum der Versorgung wird in Kooperationen mit dermatologischen Kliniken abgedeckt. In ländlicheren Gebieten sind Kooperationen seltener, wobei hier die Versorgung vor allem durch pädiatrische Abteilungen erfolgt, was im Vergleich zu Ballungsgebieten das eingeschränktere Leistungsangebot erklären könnte.
S2k‐Leitlinie Diagnostik, Prävention und Therapie des Handekzems
Authors: Bauer Andrea , Brans Richard , Brehler Randolf , Büttner Marion , Dickel Heinrich , Elsner Peter , Fartasch Manigé , Herzog Claudia , John Swen‐Malte , Köllner Arno , Maul Julia‐Tatjana , Merk Hans , Molin Sonja , Nast Alexander , Nikolakis Georgios D. , Schliemann Sybille , Skudlik Christoph , Weisshaar Elke , Werfel Thomas , Zidane Miriam , Worm Margitta 
Published: September 2023

ZusammenfassungDie S2k‐Leitlinie „Diagnostik, Prävention und Therapie des Handekzems (HE)“ gibt auf der Grundlage eines evidenz‐ und konsensbasierten Ansatzes konkrete Handlungsanweisungen und Empfehlungen für die Diagnostik, Prävention und Therapie des HE. Die Leitlinie wurde auf der Grundlage der deutschen Leitlinie „Management von Handekzemen“ aus dem Jahr 2009 und der aktuellen Leitlinie der European Society of Contact Dermatitis (ESCD) „Guidelines for diagnosis, prevention and treatment of hand eczema“ aus dem Jahr 2022 erstellt. Allgemeines Ziel der Leitlinie ist es, Dermatologen und Allergologen in der Praxis und Klinik eine akzeptierte, evidenzbasierte Entscheidungshilfe für die Auswahl sowie Durchführung einer geeigneten und suffizienten Therapie für Patienten mit Handekzemen zur Verfügung zu stellen. Die Leitlinie basiert auf zwei Cochrane‐Reviews zu therapeutischen und präventiven Interventionen beim HE. Die übrigen Kapitel wurden überwiegend basierend auf nicht systematischen Literaturrecherchen durch die Expertengruppe erarbeitet und konsentiert. Die Expertenkommission bestand aus Mitgliedern von allergologischen und berufsdermatologischen Fachgesellschaften und Arbeitsgruppen, einer Patientenvertretung und Methodikern. Im Rahmen einer Konsensuskonferenz am 15.09.2022 wurden die Vorschläge für die Empfehlungen und Kernaussagen unter Verwendung eines nominalen Gruppenprozesses konsentiert. Der strukturierte Konsensfindungsprozess wurde professionell moderiert. Die vorliegende Leitlinie hat eine Gültigkeit bis zum 22.02.2028.
Do predator odours and warmer winters affect growth of salmonid embryos?
Authors: Filipsson Karl , Erlandsson Ann , Greenberg Larry , Österling Martin , Watz Johan , Bergman Eva 
Published: September 2023

AbstractConditions early in ontogeny can have considerable effects later on in life. Many salmonids spawn during the autumn, and temperature during subsequent embryogenesis may have far‐reaching effects on life‐history traits, especially when considering ongoing climate change. Even biotic conditions during embryogenesis, such as predation threat, may affect later life stages. Here, we examined how predator odours and increased temperatures affect embryonic growth and development of a fish (brown trout Salmo trutta). We found that embryos had lower body mass and greater yolk volume close to hatching when subjected to predator odours. Trout embryos incubated at temperatures representing natural winter conditions were larger than embryos incubated at higher temperatures, although the latter hatched earlier. Fry sizes at emergence did not differ between treatments, perhaps because of compensatory growth during spring. This study shows that predator presence can have similar effects on embryonic growth of salmonids as warming winters, with possible impact later in ontogeny.
Digitalisation in pre‐purchase examination and prospects for an equine health database in Germany—Results of an online survey among equine veterinarians
Authors: Folgmann Muriel Sarah , Kleinsorgen Christin , Stock Kathrin Friederike , Meister Daniel , Hellige Maren , Feige Karsten , Delling Uta 
Published: September 2023

AbstractBackgroundDigital recording and storage of health data are becoming increasingly important in the fields of both human and veterinary medicine. There is currently a lack of information on the level of digitalisation among equine veterinarians in Germany and their attitudes towards advanced digitalisation.ObjectivesTo collect opinions of equine veterinarians about (1) digital data collection in pre‐purchase examinations (PPEs), and (2) the establishment of an equine health database in Germany.Study designCross‐sectional survey.MethodsAn online survey was developed and distributed via email exclusively to equine veterinarians in Germany. After 40 days of data collection, answers were used for descriptive statistical analyses.ResultsThe survey was sent to 1055 recipients, of which 147 (13.9%) participated and 130 survey responses from equine veterinarians could be used for analyses. Most respondents were working in an equine practice (77.9%) and performing PPEs (93.8%), for which they mostly used printed protocols (86.0%). The PPE protocol of the German Equine Veterinary Association as a paper print was the format most frequently used (47.1%). The majority of participating equine veterinarians (90.2%) would use a digital protocol for PPEs if available. Concerns were expressed about user‐friendliness (55.9%) and integration into the daily veterinary routine (54.6%). Regarding the establishment of an equine health database, 72.3% of the respondents stated they would appreciate it. However, about one‐third would support such a development only under certain conditions: guaranteed data safety, collection of objective data or involving the opinion of other stakeholders.Main limitationsLow response rate, potential non‐response bias and wide range of question topics.ConclusionA positive attitude towards digital PPEs and an equine health database in Germany became apparent. To facilitate further progress, it would be crucial to consider the concerns and conditions identified in this study to generate maximum compliance.
Yeast Tor complex 1 phosphorylates eIF4E‐binding protein, Caf20
Authors: Kamada Yoshiaki , Ando Ryoko , Izawa Shingo , Matsuura Akira 
Published: September 2023

AbstractTor complex 1 (TORC1), a master regulator of cell growth, is an evolutionarily conserved protein kinase within eukaryotic organisms. To control cell growth, TORC1 governs translational processes by phosphorylating its substrate proteins in response to cellular nutritional cues. Mammalian TORC1 (mTORC1) assumes the responsibility of phosphorylating the eukaryotic translation initiation factor 4E (eIF4E)‐binding protein 1 (4E‐BP1) to regulate its interaction with eIF4E. The budding yeast Saccharomyces cerevisiae possesses a pair of 4E‐BP genes, CAF20 and EAP1. However, the extent to which the TORC1‐4E‐BP axis regulates translational initiation in yeast remains uncertain. In this study, we demonstrated the influence of TORC1 on the phosphorylation status of Caf20 in vivo, as well as the direct phosphorylation of Caf20 by TORC1 in vitro. Furthermore, we found the TORC1‐dependent recruitment of Caf20 to the 80S ribosome. Consequently, our study proposes a plausible involvement of yeast's 4E‐BP in the efficacy of translation initiation, an aspect under the control of TORC1.
Serum vitamin D deficiency is associated with increased risk of γδ T cell exhaustion in HBV‐infected patients
Authors: Li Ke , Lu Eying , Wang Qian , Xu Ruirong , Yuan Wenhui , Wu Ruan , Lu Ligong , Li Peng 
Published: September 2023

AbstractPrevious studies have demonstrated that T cell exhaustion is associated with poor clearance of Hepatitis B virus (HBV). However, whether the expression of exhaustion markers on innate‐like circulating γδ T cells derived from patients with HBV infection correlates with the serum level of vitamin D is not completely understood. In this study, we found that the frequency of circulating Vδ2+ T cell and serum levels of vitamin 25(OH)D3 were significantly decreased in patients with HBV. And serum 25(OH)D3 levels in HBV‐infected patients were negatively correlated with HBV DNA load and PD‐1 expression on γδ T cells. Interestingly, 1α,25(OH)2D3 alleviated the exhaustion phenotype of Vδ2 T cells in HBV‐infected patients and promoted IFN‐β expression in human cytotoxic Vδ2 T cells in vitro. Collectively, these findings demonstrate that vitamin D plays a pivotal role in reversing γδ T‐cell exhaustion and is highly promising target for ameliorating HBV infection.
The influence of direct anterior approach and postero‐lateral approach on wound complications after total hip arthroplasty: A meta‐analysis
Authors: Wu Ning , Ma Jingzu , Xiong Xianghua , Luo Xiaohai , Ma Xiaolin , Yang Xiao , Wang Wei , Wang Yuhai , Wang Zhaofu , Ma Feng 
Published: September 2023

AbstractTo date, we have reviewed the synthesis literature critically through four databases: PubMed, Embase, Cochrane Library and Web of Science. Eight relevant studies were examined after compliance with the criteria for inclusion and exclusion, as well as documentation quality evaluation. This report covered all randomised, controlled studies of total hip arthroplasty (THA) comparing the direct anterior approach (DAA) with the postero‐lateral approach (PLA). The main result was surgical site infection rate. The secondary results were duration of the operation, length of the incision and VAS score after surgery. The results of the meta‐analyses of wound infections in the present trial did not show any statistically significant difference in DAA versus PLA (between DAA and PLA) (OR = 1.42, 95%CI: 0.5 to 4.04, p = 0.51). Compared with PLA, DAA had shorter surgical incision (WMD = −3.2, 95%CI: −4.00 to −2.41; p < 0.001) and longer operative times(WMD = 14. 67, 95%CI: 9.24 to 20.09; p < 0.001). Postoperative VAS scores were markedly lower in DAA compared with PLA within 6 weeks of surgery (p < 0.05), with low heterogeneities(I2 = 0). We found that DAA did not differ significantly from PLA in terms of the risk of wound infection for THA and that the surgical incisions was shorter and less postoperative pain after surgery, even though DAA surgery takes longer.
Simultaneously low resistance drift and ultra‐fast phase change speed based on GeSb/Sb multilayer thin films
Authors: Wang Cheng , Hu Yifeng , Zhang Jianhao , Zhu Xiaoqin 
Published: September 2023

AbstractThermal stability and phase transition rate are two important issues that restrict the engineering applications of phase change memories. In this paper, GeSb/Sb multilayer films were prepared by multilayer stacking, and their phase transition properties were investigated. GeSb/Sb multilayer films had higher crystallization temperature, better data retention, and lower resistance drift than pure Sb films, which indicated that they had excellent thermal stability and accuracy of resistance identification. The test results of X‐ray diffraction and atomic force microscopy showed that GeSb spacer layers could inhibit grain growth of Sb film layers, thus reducing the roughness and potential fluctuation of the film surface. X‐ray reflectivity experiments showed that the GeSb/Sb multilayer films before and after crystallization had small volume changes. The devices based on [GeSb(7 nm)/Sb(3 nm)]8multilayer films could achieve reversible resistive transition operation between SET and RESET at a pulse width of 10 ns, showing satisfactory transition rate and operational power consumption. The low resistance drift and ultra‐fast phase transition speed make GeSb/Sb multilayer films one of the promising choices for phase change memories.
Association of leadless pacing with ventricular and valvular function
Authors: Arps Kelly , Li Bicong , Allen John Carson , Alenezi Fawaz , Frazier‐Mills Camille , Al‐Khatib Sana M. , Jackson Kevin P. , Jackson Larry R. , Thomas Kevin L. , Piccini Jonathan P. 
Published: September 2023

AbstractBackgroundTraditional transvenous pacemakers are associated with worsening tricuspid valve function due to lead‐related leaflet impingement, as well as ventricular dysfunction related to electromechanical dyssynchrony from chronic right ventricular (RV) pacing. The association of leadless pacing with ventricular and valvular function has not been well established. We aimed to assess the association of leadless pacemaker placement with changes in valvular regurgitation and ventricular function.Methods and ResultsEchocardiographic features before and after leadless pacemaker implant were analyzed in consecutive patients who received a leadless pacemaker with pre‐ and postprocedure echocardiography at Duke University Hospital between November 2014 and November 2019. Valvular regurgitation was graded ordinally from 0 (none) to 3 (severe). Among 54 patients, the mean age was mean age was 70.1 ± 14.3 years, 24 (44%) were women, and the most frequent primary pacing indication was complete heart block in 24 (44%). The median RV pacing burden was 45.4 (interquartile range [IQR] 3.5–97.0). On echocardiogram performed 8.9 months (IQR 4.5–14.5) after implant, there was no change in the average severity of tricuspid regurgitation (mean change 0.07 ± 1.15, p = .64) from pre‐procedure echocardiogram. We observed a decrease in the average left ventricular ejection fraction (LVEF) (52.3 ± 9.3 to 47.9 ± 12.1, p = .0019) and tricuspid annular plane systolic excursion (TAPSE) (1.8 ± 0.6 to 1.6 ± 0.4, p = .0437). Thirteen patients (24%) had absolute drop in LVEF of ≥10%.ConclusionWe did not observe short term worsening valvular function in patients with leadless pacemakers. However, consistent with the pathophysiologic impact of RV pacing, leadless pacing was associated with a reduction in biventricular function.
A novel ablation strategy for recurrent atrial fibrillation: Fractionated signal area in the atrial muscle ablation 1‐year follow‐up
Authors: Hirokami Jun , Nagashima Michio , Fukunaga Masato , Korai Kengo , Sadohara Yohei , Kaimi Ryogo , Takeo Ayaka , Niu Harushi , Ando Kenji , Hiroshima Kenichi 
Published: September 2023

AbstractIntroductionTreatment of recurrent atrial fibrillation (AF) is sometimes challenging due to non‐pulmonary vein (PV) foci. Fractionated signal area in the atrial muscle (FAAM) is a valid predictor of the location of non‐PV foci. FAAM ablation has the potential to decrease the recurrence rate of atrial tachyarrhythmia in patients with recurrent AF. We compared the clinical impact of FAAM ablation for recurrent AF, using 1 year follow up date.MethodsA total of 230 consecutive patients with symptomatic recurrent AF who underwent catheter ablation specifically targeting non‐PV foci as FAAM‐guided ablation (n = 113) and non‐FAAM‐guided ablation (n = 117) were retrospectively analyzed. FAAM was assigned a parameter (peaks slider, which indicates the number of components of fractionated signals), ranging from 1 to 15, indicating the location of the FAAM (1: largest, 15: smallest). FAAM‐guided ablation was performed by ablating FAAM until none inducibility of non‐PV foci. On the other hand, non‐FAAM‐guided ablation was performed via linear ablation, complex fractionated atrial electrogram ablation, superior vena cava isolation, and focal ablation according to the location of the non‐PV foci. The RHYTHMIA system was used to perform all the procedures. The primary endpoints were AF recurrence, atrial flutter, and/or atrial tachycardia.ResultsAfter a 1‐year follow up, freedom from atrial tachyarrhythmia was achieved in 90.3% and 75.2% of patients in the FAAM and non‐FAAM groups, respectively (hazard ratio = 0.438 [95% confidence interval: 0.243–0.788], p  =  .005).ConclusionsFAAM ablation showed a promising decrease in the recurrence rate of atrial tachyarrhythmia in patients with recurrent AF during a 1‐year follow‐up.