bluuebunny/crossref_metadata_2025_split huggingface dataset:
Job retention vocational rehabilitation for employed people with inflammatory arthritis: adaptations to the WORKWELL trial due to the impact of the COVID-19 pandemic
Authors: Ching Angela , Parker Jennifer , Haig Alexandra , Sutton Chris J. , Cotterill Sarah , Forshaw Denise , Culley June , Hammond Alison 
Published: December 2022

AbstractThere are high levels of work disability, absenteeism (sick leave) and presenteeism (reduced productivity) amongst people with inflammatory arthritis. WORKWELL is a multi-centre, randomised controlled trial of job retention vocational rehabilitation for employed people with inflammatory arthritis. The trial tested the effectiveness and cost-effectiveness of the WORKWELL programme compared to the receipt of written self-help information only. Both arms continued to receive usual care. In March 2020, due to the COVID-19 pandemic, the WORKWELL trial paused to recruitment and intervention delivery. To successfully re-start, protocol amendments were rapidly submitted and changes to existing trial procedures were made. The WORKWELL protocol was adapted in response to both the practical issues likely faced by many clinical research studies active across NHS sites during the pandemic and additional trial-specific challenges. A key eligibility criterion for the trial required participants to be in paid work for at least 15 h per week. However, UK national lockdowns led to a substantial proportion of the workforce suddenly being furloughed or unable to work, and many people with arthritis taking immunosuppressive medications were asked to shield themselves. Thus, the number of eligible participants was reduced. Those continuing to work were harder to identify, as hospital clinics moved to remote delivery, and also to then screen, consent and treat, as the hospital research staff and clinical therapists were re-deployed. New recruitment and consent strategies were applied, and where sites had reduced capacity, responsibilities were absorbed by the trial management team. Remote intervention delivery and electronic data capture were also implemented. By rapidly adapting the WORKWELL protocol and procedures, the trial successfully reopened to recruitment in July 2020, only 4 months after the trial pause. We were able to achieve recruitment figures above the pre-COVID target and maintain a high retention rate. In addition, we found many of the protocol changes beneficial, as these streamlined trial procedures, thus improving efficiency. It is likely that many strategies implemented in response to the pandemic may become standard practice in future research within trials of a similar design and methodology.Trial registration: ClinicalTrials.gov NCT03942783. Retrospectively registered on 08 May 2019. ISRCTN Registry ISRCTN61762297. Retrospectively registered on 13 May 2019.
PrImary decompressive Craniectomy in AneurySmal Subarachnoid hemOrrhage (PICASSO) trial: study protocol for a randomized controlled trial
Authors: Güresir Erdem , Lampmann Tim , Brandecker Simon , Czabanka Marcus , Fimmers Rolf , Gempt Jens , Haas Patrick , Haj Amer , Jabbarli Ramazan , Kalasauskas Darius , König Ralph , Mielke Dorothee , Németh Robert , Oppong Marvin Darkwah , Pala Andrej , Prinz Vincent , Ringel Florian , Roder Constantin , Rohde Veit , Schebesch Karl-Michael , Wagner Arthur , Coch Christoph , Vatter Hartmut 
Published: December 2022

Abstract
Background
Poor-grade aneurysmal subarachnoid hemorrhage (SAH) is associated with poor neurological outcome and high mortality. A major factor influencing morbidity and mortality is brain swelling in the acute phase. Decompressive craniectomy (DC) is currently used as an option in order to reduce intractably elevated intracranial pressure (ICP). However, execution and optimal timing of DC remain unclear.

Methods
PICASSO resembles a multicentric, prospective, 1:1 randomized standard treatment-controlled trial which analyzes whether primary DC (pDC) performed within 24 h combined with the best medical treatment in patients with poor-grade SAH reduces mortality and severe disability in comparison to best medical treatment alone and secondary craniectomy as ultima ratio therapy for elevated ICP. Consecutive patients presenting with poor-grade SAH, defined as grade 4–5 according to the World Federation of Neurosurgical Societies (WFNS), will be screened for eligibility. Two hundred sixteen patients will be randomized to receive either pDC additional to best medical treatment or best medical treatment alone. The primary outcome is the clinical outcome according to the modified Rankin Scale (mRS) at 12 months, which is dichotomized to favorable (mRS 0–4) and unfavorable (mRS 5–6). Secondary outcomes include morbidity and mortality, time to death, length of intensive care unit (ICU) stay and hospital stay, quality of life, rate of secondary DC due to intractably elevated ICP, effect of size of DC on outcome, use of duraplasty, and complications of DC.

Discussion
This multicenter trial aims to generate the first confirmatory data in a controlled randomized fashion that pDC improves the outcome in a clinically relevant endpoint in poor-grade SAH patients.

Trial registration
DRKS DRKS00017650. Registered on 09 June 2019.
Comparison of the variability in mortality data generated by CDC bottle bioassay, WHO tube test, and topical application bioassay using Aedes aegypti mosquitoes
Authors: Althoff Rachel A. , Huijben Silvie 
Published: December 2022

Abstract
Background
Insecticide resistance remains a major public health problem. Resistance surveillance is critical for effective vector control and resistance management planning. Commonly used insecticide susceptibility bioassays for mosquitoes are the CDC bottle bioassay and the WHO tube test. Less commonly used in the field but considered the gold standard for assessing insecticide susceptibility in the development of novel insecticides is the topical application bioassay. Each of these bioassays has critical differences in how they assess insecticide susceptibility that impacts their ability to differentiate between resistant and susceptible populations or determine different levels of resistance intensity.

Methods
We compared the CDC bottle bioassay, the WHO tube test, and the topical application bioassay in establishing the dose–response against deltamethrin (DM) using the DM-resistant Aedes aegypti strain MC1. Mosquitoes were exposed to a range of insecticide concentrations to establish a dose–response curve and assess variation around model predictions. In addition, 10 replicates of 20–25 mosquitoes were exposed to a fixed dose with intermediate mortality to assess the degree of variation in mortality.

Results
The topical application bioassay exhibited the lowest amount of variation in the dose–response data, followed by the WHO tube test. The CDC bottle bioassay had the highest level of variation. In the fixed-dose experiment, a higher variance was similarly found for the CDC bottle bioassay compared with the WHO tube test and topical application bioassay.

Conclusion
These data suggest that the CDC bottle bioassay has the lowest power and the topical application bioassay the highest power to differentiate between resistant and susceptible populations and assess changes over time and between populations. This observation has significant implications for the interpretation of surveillance results from different assays. Ultimately, it will be important to discuss optimal insecticide resistance surveillance tools in terms of the surveillance objective, practicality in the field, and accuracy of the tool to reach that objective.

Graphical Abstract
Oral immunization of mice with recombinant Lactobacillus plantarum expressing a Trichinella spiralis galectin induces an immune protection against larval challenge
Authors: Xu Yang Xiu Yue , Zhang Xin Zhuo , Weng Min Min , Cheng Yong Kang , Liu Ruo Dan , Long Shao Rong , Wang Zhong Quan , Cui Jing 
Published: December 2022

Abstract
Background
Trichinella spiralis is an important foodborne parasite that presents a severe threat to food safety. The development of an anti-Trichinella vaccine is an important step towards controlling Trichinella infection in food animals and thus ensure meat safety. Trichinella spiralis galectin (Tsgal) is a novel protein that has been identified on the surface of this nematode. Recombinant Tsgal (rTsgal) was found to participate in larval invasion of intestinal epithelium cells (IECs), whereas anti-rTsgal antibodies impeded the invasion.

Methods
The rTsgal/pSIP409- pgsA′ plasmid was constructed and transferred into Lactobacillus plantarum strain NC8, following which the in vitro biological properties of rTsgal/NC8 were determined. Five groups of mice were orally immunized three times, with a 2-week interval between immunizations, with recombinant NC8-Tsgal, recombinant NC8-Tsgal + α-lactose, empty NC8, α-lactose only or phosphate-buffered saline (PBS), respectively. The vaccinated mice were infected orally with T. spiralis larvae 2 weeks following the last vaccination. Systemic and intestinal local mucosal immune responses and protection were also assessed, as were pathological changes in murine intestine and skeletal muscle.

Results
rTsgal was expressed on the surface of NC8-Tsgal. Oral immunization of mice with rTsgal vaccine induced specific forms of serum immunoglobulin G (IgG), namely IgG1/IgG2a, as well as IgA and gut mucosal secretion IgA (sIgA). The levels of interferon gamma and interleukin-4 secreted by cells of the spleen, mesenteric lymph nodes, Peyer's patches and intestinal lamina propria were significantly elevated at 2–6 weeks after immunization, and continued to rise following challenge. Immunization of mice with the oral rTsgal vaccine produced a significant immune protection against T. spiralis challenge, as demonstrated by a 57.28% reduction in the intestinal adult worm burden and a 53.30% reduction in muscle larval burden, compared to the PBS control group. Immunization with oral rTsgal vaccine also ameliorated intestinal inflammation, as demonstrated by a distinct reduction in the number of gut epithelial goblet cells and mucin 2 expression level in T. spiralis-infected mice. Oral administration of lactose alone also reduced adult worm and larval burdens and relieved partially inflammation of intestine and muscles.

Conclusions
Immunization with oral rTsgal vaccine triggered an obvious gut local mucosal sIgA response and specific systemic Th1/Th2 immune response, as well as an evident protective immunity against T. spiralis challenge. Oral rTsgal vaccine provided a prospective approach for control of T. spiralis infection.

Graphical Abstract
Exponential stability of an alternate control system with double impulses
Authors: Hu Xingkai 
Published: December 2022

AbstractIn this paper, we propose a new system called an alternate control system with double impulses. The present system is a cyclic control system, composed of four parts in a circle: to the first and last halves of each period of the system we add different continuous controls, and at the half-period time and the end of each period of the system we add different impulses. We then investigate the exponential stability of the considered system. An example based on Chua’s circuit is provided to confirm the effectiveness of the theoretical result.
Selfie phenomenon among a sample of Egyptian university students: rate and psychiatric correlates
Authors: Hashem Reem El Sayed Mohamed , Hassan Ghada A. M. , El-Sheikh Mona Mahmoud , Hassan Hadeer , Azzam Lobna Abu-Bakr Ismail 
Published: December 2022

AbstractBackgroundThe selfie phenomenon is an emanating one, specifically affecting adolescents and young adults. It emerges as a reflection of a wide spectrum of neuropsychiatric disorders. Based on this, the current study aimed to assess the rate of the selfie phenomenon among Egyptian university students and its sociodemographic and psychiatric correlates. During the study procedure, we enrolled 200 undergraduate Egyptian university students from two different faculties and were assessed using the Selfie Behavioral Scale, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Structured Clinical Interview for DSM-IV-TR Axis II Disorders, and Global Assessment of Functioning Scale.Results49.5% of the students being assessed had borderline selfitis with a higher rate among females. We found a highly significant association between the selfie phenomenon and depression, anxiety, obsessive-compulsive disorder, eating disorders, and other psychiatric disorders and personality disorders, and we also found that selfies had a significant negative association with the level of functioning among students.ConclusionsResults concur with previous existing literature regarding the magnitude of the selfie phenomenon and its relationship with different psychiatric disorders and personality disorders.
Beers criteria and potentially inappropriate medications in elderly: awareness, practice, knowledge and barriers among community pharmacists in Nigeria
Authors: Akande-Sholabi Wuraola , Fafemi Adeola 
Published: December 2022

Abstract
Background
Potential inappropriate medications (PIMs) used in the elderly are an avoidable source of disease and death. Beers Criteria is among the commonly used measures that document PIMs. Community pharmacists’ knowledge on PIMs and existing criteria are essential to moderate the use of PIMs which would enhance overall health outcomes and costs. This study investigates awareness, knowledge, practice, and barriers of PIMs among community pharmacists in Ibadan, Nigeria.

Methods
A cross-sectional study was carried out on 109 community pharmacists with the use of a self-administered questionnaire. Nine clinical vignettes based on the 2019 Beers Criteria were used to evaluate PIMs knowledge. Practice behavior regarding elderly clients was evaluated using a 5-point Likert scale with six items. Data were summarized by descriptive and inferential statistics.

Results
Respondents who knew guidelines that listed specific PIMs were (49; 47.1%), and of these, (21; 42.9%) were aware of Beers Criteria. From all the respondents, only 45 (41.3%) demonstrated good knowledge of Beers Criteria, while 82 (75.2%) narrated good practice when dealing with elderly clients in terms of asking suitable questions and contemplating their ages while dispensing medications. Major barrier identified was lack of knowledge of Beers Criteria (80; 73.4%). Pharmacists who were aware of Beers Criteria statistically had better knowledge than others (p = 0.003).

Conclusion
Beers Criteria awareness among community pharmacists is sub-optimal in Ibadan, Nigeria. Although practice when dealing with elderly customers was satisfactory, the knowledge was unsatisfactory. This underscores the need to intensify the awareness and use of guidelines that document specific PIMs such as Beers Criteria among community pharmacists.
Outcome and morbidity of liver surgery in children: a single-centre, 47-year experience
Authors: Zaidan Hind , Said Hanan , Mortell Alan , AlShafei Abdulrahman , Breatnach Finn , Heaton Nigel , Corbally Martin T. 
Published: December 2022

Abstract
Background
The outcome and survival of children with both benign and malignant liver tumours, over a 47-year period was recorded at The National Paediatric Cancer Centre, Our Lady’s Children’s Hospital (OLCHC), Crumlin. The retrospective study documents the impact of improved chemotherapy, multidisciplinary team approach and specific paediatric hepatobiliary surgical training on morbidity, outcome and survival.

Methods
A retrospective review of the hospital records of all children who presented with a primary liver tumour (benign or malignant) or a primary malignancy significantly involving the liver was undertaken. A review of the management of all such patients at OLCHC, between 1964 and 2011 was performed. This retrospective study reports on two distinct periods, group 1 (1964–1990, N = 21 patients, previously reported) and group 2 (1994–2011, N = 33). Follow-up for all group 2 patients ended in November 2014.

Results
A marked difference in survival was noted between the groups with 91% overall survival in group 2 patients as compared to 28% in group 1. Significant complications were documented in group 1 but were uncommon in group 2.

Conclusion
The improvement in mortality and morbidity reflects improved staging and chemotherapy in all patients with a malignant disease but also improved surgical strategies and multi-disciplinary team management (MDT). Specialist training in liver surgery had a significant impact on post-operative morbidity. The results suggest that in certain circumstances, rare and complex liver surgery may be performed in small centres if the necessary supports and experience co-exist.
A deep learning workflow for weak reflection extraction in pitch-catch measurements in the cased hole
Authors: Wang Qiang , Wang Hua , Shi Shaopeng 
Published: December 2022

As a key technology to evaluate cement bonds in the cased hole, an advanced ultrasonic logging tool combines pulse-echo and pitch-catch measurements in which the latter one provides reflections from the cement-formation interface (called third-interface-echo [TIE]) to evaluate the bond condition and determine casing eccentering as well as cement velocity. However, the TIE would be weak and not easy to pick due to the eccentered tool and casing and it would overlap with the strong multiple reflections between the casing inner surface and the transducer-housing tool. We have developed a deep learning workflow to extract weak TIE from noisy data and to preserve its amplitude at the same time. First, we use synthetic waveforms from thousands of finite-difference simulations as initial training data sets to train a deep learning network, which is modified from a network in speech separation. Then, the trained model is used to predict the field data through an active-learning strategy. The improved network is further used to extract the weak TIEs, which are not easy to pick in the initial deep learning model. Finally, the TIE waves image is converted to a pseudovelocity image to obtain the minimum traveltime path by solving the eikonal equation. The shortest traveltime path is used as the TIE arrival time. In addition, a 3D visualization is used to display the borehole shape from the picked arrival time. The applications in synthetic data and data set from a calibration well illustrate a good performance of our workflow in which the weakest TIE extracted from the network can reach 50 dB compared to the maximum amplitude in the full waveform. The picked arrival times can be used to reconstruct a borehole shape.
Towards simulating time evolution of specific quantum many-body system by lower counts of quantum gates
Authors: Jian Guanlin , Yang Yuan , Liu Ze , Zhu Zhen-Gang , Wang Zhengchuan 
Published: December 2022

Abstract
In the noisy intermediate-scale quantum (NISQ) era, quantum computers have become important tools to simulate the real-time evolution of strong correlated many-body systems. The general scheme of designing quantum circuits to simulate the quantum dynamics is based on the Trotter-Suzuki decomposition technique, which has its limitation because the accuracy of evolution process depends on the size of trotter steps when the evolution operator is decomposed as quantum gates. Going beyond the limitation of the Trotter-Suzuki scheme, we design a parameterized quantum circuit named α-circuit with simple determined size and the only one control parameter θ to simulate the real-time evolution of the specific XXX Heisenberg model with the specific initial state

. The α-circuit can accurately generate the time-evolution results by tuning parameter θ, which means the circuit can also be regarded as a good state preparation machine (SPM).
Facioscapulohumeral Muscular Dystrophy
Authors: Mul Karlien 
Published: December 2022

ABSTRACT

PURPOSE OF REVIEW
This article reviews the current knowledge on the clinical characteristics and disease mechanism of facioscapulohumeral muscular dystrophy (FSHD), as well as advances in targeted therapy development.

RECENT FINDINGS
FSHD has a wide range of severity, yet a distinct phenotype characterized by weakness of the facial, shoulder, and upper arm muscles, followed by weakness of the trunk and leg muscles. It can be caused by two genetic mechanisms that share a common downstream pathway, namely, the epigenetic derepression and subsequent misexpression of the myotoxic DUX4 transcription factor. Treatment is currently supportive and outlined in evidence-based guidelines. Advances in the understanding of the pathogenic mechanism of FSHD are paving the way for targeted therapy development. Approaches for targeted therapies to reduce DUX4 expression that are currently being explored include small molecules, antisense oligonucleotides, vector-based RNA interference, and gene therapy. In anticipation of more clinical trials, “clinical trial preparedness,” including the development of sensitive biomarkers and clinical outcome measures, are needed.

SUMMARY
The cornerstones of the diagnosis of FSHD are clinical observation and genetic testing. Management is currently supportive, but progress in the understanding of the disease mechanism has shifted the field of FSHD toward targeted therapy development.
Metabolic Myopathies
Authors: Tarnopolsky Mark A. 
Published: December 2022

ABSTRACTPURPOSE OF REVIEWMetabolic myopathies are disorders that affect skeletal muscle substrate oxidation. Although some drugs and hormones can affect metabolism in skeletal muscle, this review will focus on the genetic metabolic myopathies.RECENT FINDINGSImpairments in glycogenolysis/glycolysis (glycogen storage disease), fatty acid transport/oxidation (fatty acid oxidation defects), and mitochondrial metabolism (mitochondrial myopathies) represent most metabolic myopathies; however, they often overlap clinically with structural genetic myopathies, referred to as pseudometabolic myopathies. Although metabolic myopathies can present in the neonatal period with hypotonia, hypoglycemia, and encephalopathy, most cases present clinically in children or young adults with exercise intolerance, rhabdomyolysis, and weakness. In general, the glycogen storage diseases manifest during brief bouts of high-intensity exercise; in contrast, fatty acid oxidation defects and mitochondrial myopathies usually manifest during longer-duration endurance-type activities, often with fasting or other metabolic stressors (eg, surgery, fever). The neurologic examination is often normal between events (except in the pseudometabolic myopathies) and evaluation requires one or more of the following tests: exercise stress testing, blood (eg, creatine kinase, acylcarnitine profile, lactate, amino acids), urine (eg, organic acids, myoglobin), muscle biopsy (eg, histology, ultrastructure, enzyme testing), and targeted (specific gene) or untargeted (myopathy panels) genetic tests.SUMMARYDefinitive identification of a specific metabolic myopathy often leads to specific interventions, including lifestyle, exercise, and nutritional modifications; cofactor treatments; accurate genetic counseling; avoidance of specific triggers; and rapid treatment of rhabdomyolysis.