bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gabapentin Use Among Individuals Initiating Buprenorphine Treatment for Opioid Use Disorder
Authors: Ellis Matthew S. , Xu Kevin Y. , Tardelli Vitor S. , Fidalgo Thiago M. , Buttram Mance E. , Grucza Richard A. 
Published: September 2023

ImportanceGabapentin prescriptions have drastically increased in the US due to off-label prescribing in settings such as opioid use disorder (OUD) treatment to manage a range of comorbid conditions and withdrawal symptoms, despite a lack of evidence.ObjectiveTo assess the purpose and associated risks of off-label gabapentin use in OUD treatment.Design, Setting, and ParticipantsThis retrospective recurrent-event case-control study with a crossover design used administrative claims data from MarketScan Commercial and Multi-State Medicaid databases from January 1, 2006, to December 31, 2016. Individuals aged 12 to 64 years with an OUD diagnosis and filling buprenorphine prescriptions were included in the primary analysis conducted from July 1, 2022, through June 1, 2023. Unit of observation was the person-day.ExposuresDays covered by filled gabapentin prescriptions.Main Outcomes and MeasuresPrimary outcomes were receipt of gabapentin in the 90 days after initiation of buprenorphine treatment and drug-related poisoning. Drug-related poisonings were defined using codes from International Classification of Diseases, Ninth Revision, and International Statistical Classification of Diseases and Related Health Problems, Tenth Revision.ResultsA total of 109 407 patients were included in the analysis (mean [SD] age, 34.0 [11.2] years; 60 112 [54.9%] male). Among the 29 967 patients with Medicaid coverage, 299 (1.0%) were Hispanic, 1330 (4.4%) were non-Hispanic Black, 23 112 (77.1%) were non-Hispanic White, and 3399 (11.3%) were other. Gabapentin was significantly less likely to be prescribed to Black or Hispanic patients, and more likely to be prescribed to female patients, those with co-occurring substance use or mood disorders, and those with comorbid physical conditions such as neuropathic pain. Nearly one-third of persons who received gabapentin (4336 [31.1%]) had at least 1 drug-related poisoning after initiating buprenorphine treatment, compared with 13 856 (14.5%) among persons who did not receive gabapentin. Adjusted analyses showed that days of gabapentin use were not associated with hospitalization for drug-related poisoning (odds ratio, 0.98 [95% CI, 0.85-1.13]). Drug-related poisoning risks did not vary based on dosage.Conclusions and RelevanceGabapentin is prescribed in the context of a myriad of comorbid conditions. Even though persons receiving gabapentin are more likely to have admissions for drug-related poisoning, these data suggest that gabapentin is not associated with an increased risk of drug-related poisoning alongside buprenorphine in adjusted analyses. More data on the safety profile of gabapentin in OUD settings are needed.
Polarization‐Sensitive Optoelectronic Synapse Based on 3D Graphene/MoS2 Heterostructure
Authors: Li Yuning , Zhang Yang , Wang Yuqiang , Sun Jingye , You Qing , Zhu Mingqiang , Li Linan , Deng Tao 
Published: September 2023

AbstractOptoelectronic synapses with information sensing, processing, and memory function are promoting the development of artificial visual perception systems. However, optoelectronic synapses' relatively inferior optoelectronic performance impedes their application in complex neuromorphic computing. Herein, optoelectronic synapses based on 3D graphene/molybdenum disulfide (MoS2) heterostructure field‐effect transistors are developed by using the double stress layer self‐rolled‐up method. The graphene, with excellent electrical properties, enhances the carrier transport capacity of the device. The unique continuous photoconductivity of MoS2 is suitable for simulating various synaptic nerve morphological functions. Meanwhile, the 3D resonant microcavity is added to enhance the optical field and make the device polarization sensitive, which reveals more intangible features of objects. The device demonstrates room‐temperature photodetection at ultraviolet, visible, near‐infrared, and mid‐infrared regions, with photoresponsivity up to 105 A W−1 at 590 nm. Furthermore, multiple synaptic neuromorphic functions, such as inhibitory postsynaptic current, paired‐pulse facilitation, short‐term depression, and long‐term depression, are successfully emulated. Here a new concept is provided for designing high‐performance optoelectronic synapses with polarization sensitivity and excellent potential in artificial intelligence is shown.
Uniform and Multifunctional PEI‐POSS/Carbon Encapsulation for High‐Rate Performance and Surface Stabilization of Nickel‐Rich Layered Cathodes in Lithium‐Ion Batteries
Authors: Hwang Jeonguk , Lee Sanghyun , Kim Sucheol , Do Kwanghyun , Kim Sungwook , Jo Hyeonmin , Lim Hee‐Dae , Ahn Heejoon 
Published: September 2023

AbstractGraphene encapsulation is an attractive surface‐coating technology that can simultaneously improve the rate capability and cycle stability of nickel‐rich LiNixCoyMn1−x−yO2 (NCM). Here, carbon encapsulation with the addition of polyethylenimine (PEI) and polyhedral oligomeric silsesquioxane (POSS), which can effectively suppress access to and generation of harmful factors in the electrolyte to maximize the rate performance and cycle stability of nickel‐rich NCM, is described. The PEI‐POSS/carbon layer not only facilitates electron and lithium‐ion transport on the NCM surface but also inhibits side reactions with the electrolyte during repeated electrochemical reactions. In addition, it provides mechanical support that suppresses the formation of microcracks related to anisotropic volume change of nickel‐rich NCM secondary particles and inhibits irreversible phase transitions on surface structures by mitigating electrolyte wettability. As a result, PEI‐POSS/carbon‐encapsulated NCM exhibits a higher rate capability (84 mAh g−1 at 5 C) and cycle stability (93.5% for 100 cycles at 1 C) compared with bare NCM (0 mAh g−1 at 5 C and 78.4% for 100 cycles at 1 C). In a cycle test at 45 °C, it achieves a capacity retention of 72.6% for 100 cycles at 1 C, which is a 323% improvement in performance over that of bare NCM (22.5%).
Ultradurable Omni‐Liquid‐Repellent Smart Window as a High‐Performance Wettability/Transparency Manipulator Enabled via Laser‐Writing Magnetism‐Actuated Microshutters
Authors: Chen Chao , Yao Hao , Chen Yan , Zhang Long , Guo Sijia , Wu Sizhu , Li Shuyi , Lao Zhaoxin , Zhang Chenchu 
Published: September 2023

AbstractSlippery liquid‐infused porous surfaces (SLIPS) derived smart windows (SWs) that dynamically fine‐tune the solar spectrum are promising candidates for alleviating the global energy crisis, especially for dim rainy climates. Unfortunately, the inferior durability, high energy‐consumption, and slow tune‐responsivity over SLIPS‐based SWs greatly hinder their practical usage. Reported is an ultrarobust omni‐liquid‐repellent magnetism‐actuated reconfigurable microshutters (OLR‐MARS) via integrating a femtosecond laser ablation and soft‐lithography technique. By alternately loading/discharging a remote magnet, OLR‐MARS can be reversibly switched between a transparent mode and an opaque mode within 0.03 s, which is far sensitive than the previously‐reported SWs. Simultaneously, OLR‐MARS can harness the surface liquids between a slippery state (the sliding angle of ≈15o) and a sticky one (pinning at a tilt angle of 90o). Significantly, owing to its all‐solid‐state merit, OLR‐MARS demonstrates good longevity even when subjected to the raindrops impact above 1000 cycles. Results indicate dual switching over the interfacial hydrodynamics and optics. Last but not least, leveraging the optimized OLR‐MARS, encryption‐decryption, thermal management, and an angle‐dependent privacy‐screen is deployed. Current novel OLR‐MARS with robust durability, fast responsivity, and energy‐free advantages holds promising potential in self‐cleaning smart windows, energy‐saving buildings, antivoyeurism, etc.
Intrafibrillar Crosslinking Enables Decoupling of Mechanical Properties and Structure of a Composite Fibrous Hydrogel
Authors: Chen Zhengkun , Ezzo Maya , Zondag Benjamen , Rakhshani Faeze , Ma Yingshan , Hinz Boris , Kumacheva Eugenia 
Published: September 2023

AbstractThe fibrous network of an extracellular matrix (ECM) possesses mechanical properties that convey critical biological functions in cell mechanotransduction. Engineered fibrous hydrogels show promise in emulating key aspects of ECM structure and functions. However, varying hydrogel mechanics without changing its architecture remains a challenge. A composite fibrous hydrogel is developed to vary gel stiffness without affecting its structure by controlling intrafibrillar crosslinking. The hydrogel is formed from aldehyde‐modified cellulose nanocrystals and gelatin methacryloyl that provide the capability of intrafibrillar photocrosslinking. By varying the degree of gelatin functionalization with methacryloyl groups and/or photoirradiation time, the hydrogel's elastic modulus is changed by more than an order of magnitude, while preserving the same fiber diameter and pore size. The hydrogel is used to seed primary mouse lung fibroblasts and test the role of ECM stiffness on fibroblast contraction and activation. Increasing hydrogel stiffness by stronger intrafibrillar crosslinking results in enhanced fibroblast activation and increased fibroblast contraction force, yet at a reduced contraction speed. The developed approach enables the fabrication of biomimetic hydrogels with decoupled structural and mechanical properties, facilitating studies of ECM mechanics on tissue development and disease progression.
Liquid Nanoparticles for Nanocatalytic Cancer Therapy
Authors: Hu Ruizhi , Chen Xiaoying , Li Zhifang , Zhao Guojun , Ding Li , Chen Liang , Dai Chen , Chen Yu , Zhang Bo 
Published: September 2023

AbstractNanotechnology is revolutionizing cancer therapy, and catalyzes the emerging of ion‐involved cancer‐therapeutic modality, which unfortunately suffers from undesirable nanocarriers for efficient intracellular ion delivery. To radically extricate from this critical issue, the glutathione (GSH)‐responsive organosilica network is employed to lock the liquid drops at the nanoscale via a general bottom‐up strategy to achieve the systemic delivery of “ion drugs”. In this work, a sulfate radical generation donor (Na2S2O8), as a paradigm “ion drug”, is entrapped into this liquid nanoparticle for efficiently delivering to the tumor region. After further surface engineering with pH‐responsive tannic acid‐Fe2+ framework, these liquid nanoparticles achieve tumor‐microenvironmental pH/GSH‐dual responsive ion release (Fe2+/Na+/S2O82−) after reaching the tumor sites, where the Fe2+ further triggers S2O82− to generate toxic •SO4− and •OH, effectively executing cancer cell ferroptosis (Fe2+, reactive oxygen species—ROS) and pyroptosis (Na+, ROS). Such a tumor‐responsive/specific liquid nanoplatform is highly instructive for further ion‐mediated nanomedicine and disease treatment.
Potential of Estradiol‐Functionalized Polyisocyanide Hydrogels for Stimulating Tissue Regeneration of the Pelvic Floor
Authors: van Velthoven Melissa J. J. , Gudde Aksel N. , Enting Hilde , Hammink Roel , Roovers Jan‐Paul , Guler Zeliha , Oosterwijk Egbert , Kouwer Paul H. J. 
Published: September 2023

AbstractThe high reoperation rate in pelvic organ prolapse (POP) surgery is probably due to impaired wound healing, and therefore, novel strategies that promote tissue regeneration are urgently needed. Estrogen therapy shows beneficial effects for vaginal wound healing: it reduces the inflammatory response and improves vaginal tissue strength and quality. Earlier, scaffolds that release the most potent estrogen, β‐estradiol (E2) have been described. This work describes the results of conjugating E2 covalently to the synthetic, but highly mimetic, polyisocyanide hydrogel (PIC‐E2). As adipose‐derived stem cells (ASCs) possess regenerative capabilities, the combination of PIC‐E2 and ASCs may have a synergistic effect on pelvic floor tissue regeneration. The results show that the PIC‐E2 bioactivity is not hampered upon covalent E2 conjugation and upregulates various extracellular matrix (ECM) genes in ASCs. Moreover, PIC‐E2 exerts similar effects regarding ECM metabolism compared to other E2‐releasing biomaterials, but at much lower doses, which is economically and therapeutically favorable. Based on these in vitro findings, the combination of the PIC‐E2 hydrogel and ASCs may have the potential to stimulate tissue regeneration in vivo, and therefore, feasibly improve the surgical outcomes for POP in the future.
In Situ Atomic‐Scale Investigation of Structural Evolution During Sodiation/Desodiation Processes in Na3V2(PO4)3‐Based All‐Solid‐State Sodium Batteries
Authors: Shen Fang‐Chun , Ma Qianli , Tietz Frank , Kao Jui‐Cheng , Huang Chi‐Ting , Hernandha Rahmandhika Firdauzha Hary , Huang Chun‐Wei , Lo Yu‐Chieh , Chang Jeng‐Kuei , Wu Wen‐Wei 
Published: September 2023

AbstractRecently, all‐solid‐state sodium batteries (Na‐ASSBs) have received increased interest owing to their high safety and potential of high energy density. The potential of Na‐ASSBs based on sodium superionic conductor (NASICON)‐structured Na3V2(PO4)3(Na3VP) cathodes have been proven by their high capacity and a long cycling stability closely related to the microstructural evolution. However, the detailed kinetics of the electrochemical processes in the cathodes is still unclear. In this work, the sodiation/desodiation process of Na3VP is first investigated using in situ high‐resolution transmission electron microscopy (HRTEM). The intermediate Na2V2(PO4)3 (Na2VP) phase with the P21/c space group, which would be inhibited by constant electron beam irradiation, is observed at the atomic scale. With the calculated volume change and the electrode–electrolyte interface after cycling, it can be concluded that the Na2VP phase reduces the lattice mismatch between Na3VP and NaV2(PO4)3 (NaVP), preventing structural collapse. Based on the density functional theory calculation (DFT), the Na+ ion migrates more rapidly in the Na2VP structure, which facilitates the desodiation and sodiation processes. The formation of Na2VP phase lowers the formation energy of NaVP. This study demonstrates the dynamic evolution of the Na3VP structure, paving the way for an in‐depth understanding of electrode materials for energy‐storage applications.
Can heterosis and inbreeding depression explain the maintenance of outcrossing in a cleistogamous perennial?
Authors: Soto Tatyana Y. , Rojas‐Gutierrez Juan Diego , Oakley Christopher G. 
Published: September 2023

AbstractPremiseWhat maintains mixed mating is an evolutionary enigma. Cleistogamy—the production of both potentially outcrossing chasmogamous and obligately selfing cleistogamous flowers on the same individual plant—is an excellent system to study the costs of selfing. Inbreeding depression can prevent the evolution of greater selfing within populations, and heterosis in crosses between populations may further tip the balance in favor of outcrossing. Few empirical estimates of inbreeding depression and heterosis in the same system exist for cleistogamous species.MethodsWe investigate the potential costs of selfing by quantifying inbreeding depression and heterosis in three populations of the cleistogamous perennial Ruellia humilis Nutt (Acanthaceae). We performed three types of hand‐pollinations—self, outcross‐within, and outcross‐between populations—and measured seed number, germination, total flower production, and estimated cumulative fitness for the resulting progeny in a greenhouse experiment.ResultsWe found moderate inbreeding depression for cumulative fitness (<30%) in two populations, but outbreeding depression for crosses within a third population (–26%). For between‐population crosses, there was weak to modest heterosis (11–47%) in two of the population combinations, but modest to strong outbreeding depression (–21 to –71%) in the other four combinations.ConclusionsNeither inbreeding depression nor heterosis was of sufficient magnitude to explain the continued production of chasmogamous flowers given the relative energetic advantage of cleistogamous flowers previously estimated for these populations. Outbreeding depression either within or between populations makes the maintenance of chasmogamous flowers even harder to explain. More information is needed on the genetic basis of cleistogamy to resolve this conundrum.
Plasma Alzheimer's biomarkers and brain amyloid in Hispanic and non‐Hispanic older adults
Authors: Asken Breton M. , Wang Wei‐En , McFarland Karen , Arias Franchesca , Fiala Jacob , Velez‐Uribe Idaly , Mayrand Robin P. , Sawada Luana Okino , Freytes Christian , Adeyosoye Michael , Marsiske Michael , Rosselli Monica , Barker Warren W. , Curiel Cid Rosie , Loewenstein David A. , DeKosky Steven T. , Armstrong Melissa J. , Smith Glenn E. , Adjouadi Malek , Vaillancourt David E. , Duara Ranjan 
Published: September 2023

AbstractINTRODUCTIONAlzheimer's disease studies often lack ethnic diversity.METHODSWe evaluated associations between plasma biomarkers commonly studied in Alzheimer's (p‐tau181, GFAP, and NfL), clinical diagnosis (clinically normal, amnestic MCI, amnestic dementia, or non‐amnestic MCI/dementia), and Aβ‐PET in Hispanic and non‐Hispanic older adults. Hispanics were predominantly of Cuban or South American ancestry.RESULTSThree‐hundred seventy nine participants underwent blood draw (71.9 ± 7.8 years old, 60.2% female, 57% Hispanic of which 88% were Cuban or South American) and 240 completed Aβ‐PET. P‐tau181 was higher in amnestic MCI (p = 0.004, d = 0.53) and dementia (p < 0.001, d = 0.97) than in clinically normal participants and discriminated Aβ‐PET[+] and Aβ‐PET[‐] (AUC = 0.86). P‐tau181 outperformed GFAP and NfL. There were no significant interactions with ethnicity. Among amnestic MCI, Hispanics had lower odds of elevated p‐tau181 than non‐Hispanic (OR = 0.41, p = 0.006).DISCUSSIONPlasma p‐tau181 informs etiological diagnosis of cognitively impaired Hispanic and non‐Hispanic older adults. Hispanic ethnicity may relate to greater likelihood of non‐Alzheimer's contributions to memory loss.Highlights
Alzheimer's biomarkers were measured in Hispanic and non‐Hispanic older adults.
Plasma p‐tau181 related to amnestic cognitive decline and brain amyloid burden.
AD biomarker associations did not differ between Hispanic and non‐Hispanic ethnicity.
Hispanic individuals may be more likely to have non‐Alzheimer causes of memory loss.
Point‐of‐Care Testing for the Detection of MicroRNAs: Towards Liquid Biopsy on a Chip
Authors: Moro Giulia , Fratte Chiara Dalle , Normanno Nicola , Polo Federico , Cinti Stefano 
Published: September 2023

AbstractPoint‐of‐care (PoC) testing is revolutionizing the healthcare sector improving patient care in daily hospital practice and allowing reaching even remote geographical areas. In the frame of cancer management, the design and validation of PoC enabling the non‐invasive, rapid detection of cancer markers is urgently required to implement liquid biopsy in clinical practice. Therefore, focusing on stable blood‐based markers with high‐specificity, such as microRNAs, is of crucial importance. In this work, we highlight the potential impact of circulating microRNAs detection on cancer management and the crucial role of PoC testing devices, especially for low‐income countries. A detailed discussion about the challenges that should be faced to promote the technological transfer and clinical use of these tools has been added, to provide the readers with a complete overview of potentialities and current limitations.
Retrosynthetic Analysis Applied to Clip‐off Chemistry: Synthesis of Four Rh(II)‐Based Complexes as Proof‐of‐Concept
Authors: Broto‐Ribas Anna , Ruiz‐Relaño Sara , Albalad Jorge , Yang Yunhui , Gándara Felipe , Juanhuix Judith , Imaz Inhar , Maspoch Daniel 
Published: September 2023

AbstractClip‐off Chemistry is a synthetic strategy that our group previously developed to obtain new molecules and materials through selective cleavage of bonds. Herein, we report recent work to expand Clip‐off Chemistry by introducing into it a retrosynthetic analysis step that, based on virtual extension of the products through cleavable bonds, enables one to define the required precursor materials. As proof‐of‐concept, we have validated our new approach by synthesising and characterising four aldehyde‐functionalised Rh(II)‐based complexes: a homoleptic cluster; a cis‐disubstituted paddlewheel cluster; a macrocycle; and a crown.
Palladium/Norbornene‐Catalyzed Direct Vicinal Di‐Carbo‐Functionalization of Indoles: Reaction Development and Mechanistic Study
Authors: Liu Xin , Zhou Yun , Qi Xiaotian , Li Renhe , Liu Peng , Dong Guangbin 
Published: September 2023

AbstractMethods that can simultaneously install multiple different functional groups to heteroarenes via C−H functionalizations are valuable for complex molecule synthesis, which, however, remain challenging to realize. Here we report the development of vicinal di‐carbo‐functionalization of indoles in a site‐ and regioselective manner, enabled by the palladium/norbornene (Pd/NBE) cooperative catalysis. The reaction is initiated by the Pd(II)‐mediated C3‐metalation and specifically promoted by the C1‐substituted NBEs. The mild, scalable, and robust reaction conditions allow for a good substrate scope and excellent functional group tolerance. The resulting C2‐arylated C3‐alkenylated indoles can be converted to diverse synthetically useful scaffolds. The combined experimental and computational mechanistic study reveals the unique role of the C1‐substituted NBE in accelerating the turnover‐limiting oxidative addition step.
Trimethylsilyl Chloride Aids in Solubilization of Oxidative Addition Intermediates from Zinc Metal
Authors: Hanada Erin M. , McShea Patrick J. , Blum Suzanne A. 
Published: September 2023

AbstractTrimethylsilyl chloride (TMSCl) is commonly used to “activate” metal(0) powders toward oxidative addition of organohalides, but knowledge of its mechanism remains limited by the inability to characterize chemical intermediates under reaction conditions. Here, fluorescence lifetime imaging microscopy (FLIM) overcomes these prior limitations and shows that TMSCl aids in solubilization of the organozinc intermediate from zinc(0) metal after oxidative addition, a previously unknown mechanistic role. This mechanistic role is in contrast to previously known roles for TMSCl before the oxidative addition step. To achieve this understanding, FLIM, a tool traditionally used in biology, is developed to characterize intermediates during a chemical reaction—thus revealing mechanistic steps that are unobservable without fluorescence lifetime data. These findings impact organometallic reagent synthesis and catalysis by providing a previously uncharacterized mechanistic role for a widely used activating agent, an understanding of which is suitable for revising activation models and for developing strategies to activate currently unreactive metals.