bluuebunny/crossref_metadata_2025_split huggingface dataset:
Piano in Electroacoustic Discourse of Sound Representations
Authors: Kravchenko Anastasiia 
Published: September 2023

The purpose of the article is to study the piano’s performance expression in sound representations of electroacoustic opuses by Ukrainian composers. The research methodology is based on musicological, semiotic, cultural, and hermeneutical analysis. The scientific novelty of the study is that for the first time in the study of electroacoustic music of Ukraine, the importance of instrumentalism, namely piano lexicon, in the performance interpretation of sound images of a person, an epoch and the world reproduced in the semiotic-communicative and artistic-figurative space of electroacoustic compositions is emphasised. Conclusions. The creativity of regional composing schools in Ukraine is marked by the use of music and information technologies, as evidenced by the emergence of electromusical, electroacoustic, and audiovisual opuses. Electroacoustic music in Ukraine has a wide range of genre models of a hybrid type, combining the possibilities of acoustic instruments and multimedia technologies. The analysis of works for piano and magnetic tape by K. Tsepkolenko and A. Karnak shows that digital audio modifications provide an expansion of the audio spectrum through processing and programming of the series of sound, noise, and speech genesis, where verbal components reveal the ideological and conceptual basis of the compositions. The expression of the piano, embodied in the stylistics of modernism and avant-garde, shows the absence of elements of ethno-national character, which emphasises the tendency to a "globalised" type of performance aesthetics. In the semiotic and communicative interaction of the piano instrumental part with electronic media, a unique environment of multidimensional unity of movement, time, and space is formed. It reflects the sound images of a person, an epoch and the world in modelling the general philosophical picture of the dual oppositions of immanent and transcendent, which has historical and non-historical significance.
Key words: electroacoustics, music information technologies, composing school, piano art, piano performance, sound image, philosophical picture of the world.
Perspectivas da rede de Atenção Primária à Saúde ao Comportamento Suicida
Authors: Rodrigues Jeferson , Leal Ferreira Micheli , Ambrosina de Oliveira Vargas Mara , Zilli Francielly , Trentin Daiane , Antunes Lucas 
Published: September 2023

Objetivo: analisar a atuação dos profissionais da atenção primária à saúde à pessoa com comportamento suicida na perspectiva de redes de atenção. Métodos: pesquisa qualitativa desenvolvida com 19 profissionais da saúde de nível superior e com profissionais da gestão dos serviços da atenção primária à saúde de um município catarinense, realizada durante o período de agosto a setembro de 2018. Resultados: O comportamento suicida não é facilmente identificado, pois sua avaliação engloba o caminho percorrido na rede de atenção primária à saúde, e as dificuldades encontradas estão associadas à ausência de um protocolo ou diretriz que define e padroniza as ações. Conclusão: O estabelecimento de vínculo e aproximação entre profissionais e sujeitos acolhidos são apontados como importantes na atuação profissional, e as unidades básicas de saúde foram apontadas como a principal porta de entrada e gestora dos cuidados, embora a articulação entre os serviços enfrente limitações.
Margins of postural stability in Parkinson’s disease: an application of control theory
Authors: Rahmati Zahra , Behzadipour Saeed , Taghizadeh Ghorban 
Published: September 2023

Introduction: Postural instability is a restrictive feature in Parkinson’s disease (PD), usually assessed by clinical or laboratory tests. However, the exact quantification of postural stability, using stability theorems that take into account human dynamics, is still lacking. We investigated the feasibility of control theory and the Nyquist stability criterion—gain margin (GM) and phase margin (PM)—in discriminating postural instability in PD, as well as the effects of a balance-training program.Methods: Center-of-pressure (COP) data of 40 PD patients before and after a 4-week balance-training program, and 20 healthy control subjects (HCs) (Study1) as well as COP data of 20 other PD patients at four time points during a 6-week balance-training program (Study2), collected in two earlier studies, were used. COP was recorded in four tasks, two on a rigid surface and two on foam, both with eyes open and eyes closed. A postural control model (an inverted pendulum with a Proportional-integral-derivative (PID) controller and time delay) was fitted to the COP data to subject-specifically identify the model parameters thereby calculating |GM| and PM for each subject in each task.Results: PD patients had a smaller margin of stability (|GM| and PM) compared with HCs. Particularly, patients, unlike HCs, showed a drastic drop in PM on foam. Clinical outcomes and margins of stability improved in patients after balance training. |GM| improved early in week 4, followed by a plateau during the rest of the training. In contrast, PM improved late (week 6) in a relatively continuous-progression form.Conclusion: Using fundamental stability theorems is a promising technique for the standardized quantification of postural stability in various tasks.
Clinical relevance and outcome of familial papillary thyroid cancer: a single institution study of 626 familial cases
Authors: Li Zhuyao , Zhang Hongri , Yan Yu , Li Xiang , Jia Meng , Zhou Honglong , Lu Xiubo 
Published: September 2023

BackgroundWhether familial thyroid cancer is more aggressive than sporadic thyroid cancer remains controversial. Additionally, whether the number of affected family members affects the prognosis is unknown. This study focused mainly on the comparison of the clinicopathological characteristics and prognoses between papillary thyroid cancer (PTC) patients with and without family history.MethodsA total of 626 familial papillary thyroid cancer (FPTC) and 1252 sporadic papillary thyroid cancer (SPTC) patients were included in our study. The clinical information associated with FPTC and SPTC was recorded and analyzed by univariate analysis.ResultsPatients in the FPTC group had a higher rate of multifocality (p=0.001), bilaterality (p=0.000), extrathyroidal invasion (p=0.000), distant metastasis (p=0.012), lymph node metastasis (p=0.000), recurrence (p=0.000), a larger tumor size (p=0.000) and more malignant lymph nodes involved (central: p=0.000; lateral: p=0.000). In addition, our subgroup analysis showed no significant difference (p&gt;0.05) between patients with only one affected family member and those with two of more group in all clinicopathological characteristics. In papillary thyroid microcarcinoma (PTMC) subgroup analysis, we found that FPTMC patients harbored significantly larger tumors (p=0.000), higher rates of multifocality (p=0.014), bilaterality (p=0.000), distant metastasis (p=0.038), lymph node metastasis (p=0.003), greater numbers of malignant lymph nodes (central: p=0.002; lateral: p=0.044), higher rates of I-131 treatment (p=0.000) and recurrence (p=0.000) than SPTMC patients.ConclusionOur results indicated that PTC and PTMC patients with a positive family history had more aggressive clinicopathological behaviors, suggesting that more vigilant screening and management for FPTC may be helpful.
Molecular surveillance of dengue virus in field-collected Aedes mosquitoes from Bhopal, central India: evidence of circulation of a new lineage of serotype 2
Authors: Sarma Devojit Kumar , Rathod Lokendra , Mishra Sweta , Das Deepanker , Agarwal Ankita , Sharma Gaurav , Singh Tanim Arpit , Kumawat Manoj , Singh Samradhi , Verma Vinod , Kumar Manoj , Shubham Swasti , Tiwari Rajnarayan R. , Prakash Anil 
Published: September 2023

IntroductionDengue fever is hyperendemic in several Southeast and South Asian countries, including India, with all four serotypes (DENV 1–4) circulating at different periods and in different locations. Sustainable and improved virological and entomological surveillance is the only tool to prevent dengue and other vector-borne diseases.ObjectivesThe present study has been carried out to detect and characterize the circulating dengue virus (DENV) in field-collectedAedesmosquitoes in Bhopal, Central India.MethodsAedesmosquitoes were collected from 29 localities within Bhopal city during October 2020 to September 2022. DENV infection was assessed in the individual head and thorax regions ofAedesmosquitoes using reverse transcriptase PCR. Positive samples were sequenced, and the circulating serotypes and genotypes were determined using phylogenetic analysis.ResultsDENV RNA was detected in 7Aedes aegyptiand 1Aedes albopictus, with infection rates of 0.59 and 0.14%, respectively. Phylogenetic analysis revealed all the isolates belonged to DENV serotype 2 and distinctly clustered with the non-Indian lineage (cosmopolitan genotype 4a), which was not recorded from the study area earlier. The time to most common recent ancestor (TMRCA) of these sequences was 7.4 years old, with the highest posterior density (HPD) of 3.5–12.2 years, indicating that this new lineage emerged during the year 2014. This is the first report on the DENV incrimination in bothAe. aegyptiandAe. albopictusmosquitoes collected from Bhopal, Central India.ConclusionThe observed emergence of the non-Indian lineage of DENV-2 in Bhopal, which again is a first report from the area, coincides with the gradual increase in DENV cases in Bhopal since 2014. This study emphasizes the importance of DENV surveillance and risk assessment in this strategically important part of the country to decipher its outbreak and severe disease-causing potential.
The neutrophil-to-lymphocyte ratio is associated with mild cognitive impairment in community-dwelling older women aged over 70 years: a population-based cross-sectional study
Authors: Li Shengjie , Chen Xiaoyu , Gao Mengze , Zhang Xingyu , Han Peipei , Cao Liou , Gao Jing , Tao Qiongying , Zhai Jiayi , Liang Dongyu , Guo Qi 
Published: September 2023

BackgroundThe neutrophil-to-lymphocyte ratio (NLR) is a marker of inflammation that can be obtained quickly, conveniently, and cheaply from blood samples. However, there is no research to explore the effects of sex and age on the relationship between the NLR and mild cognitive impairment (MCI) in community-dwelling older adults.MethodsA total of 3,169 individuals aged over 60 years in Shanghai were recruited for face-to-face interviews, and blood samples were collected. MCI was assessed by the Mini-Mental State Examination (MMSE) and the Instrumental Activities of Daily Living (IADL) scale, and neutrophil count and lymphocyte counts were measured in fasting blood samples. The NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count.ResultsIn females, the NLR in the MCI group was significantly higher than that in the cognitively normal group (2.13 ± 0.94 vs. 1.85 ± 0.83, p &lt; 0.001) but not in men. Logistic regression showed that a higher NLR was an independent risk factor for MCI in women [odds ratio (OR) = 1.28; 95% confidence interval (CI) = 1.09–1.49]. In addition, the elevated NLR quartile was associated with an increased risk of MCI, especially in women older than 70 years (p-value for trend = 0.011).ConclusionCompared with males, female MCI patients had a significantly higher NLR than cognitively normal controls. In addition, elevated NLR was found to be significantly associated with MCI risk in women older than 70 years. Therefore, elderly Chinese women with a higher NLR value may be the target population for effective prevention of MCI.
Aspiration thrombectomy with the Penumbra System for patients with stroke and late onset to treatment: a subset analysis of the COMPLETE registry
Authors: Hassan Ameer E. , Fifi Johanna T. , Zaidat Osama O. 
Published: September 2023

BackgroundThe purpose of this study was to report the safety and performance of aspiration thrombectomy with the Penumbra System for patients with acute ischemic stroke (AIS) due to anterior circulation large vessel occlusion (LVO) and late onset to treatment.MethodsThis is a retrospective subset analysis of a global prospective multicenter registry (COMPLETE) that enrolled adults with AIS due to LVO and a pre-stroke modified Rankin Scale score (mRS) of 0 or 1 who were treated first-line with aspiration thrombectomy either alone (A Direct Aspiration First Pass Technique [ADAPT]) or in combination with the 3D Revascularization Device (ADAPT + 3D). This subset analysis included all patients in the registry who had anterior circulation LVO, an Alberta Stroke Program Early CT Score of at least 6, and late onset to treatment (&gt;6 h from stroke onset to puncture).ResultsOf the 650 patients in the COMPLETE registry, 167 were included in this subset analysis. The rate of successful revascularization (modified thrombolysis in cerebral infarction score 2b-3 achieved) at the end of the procedure was 83.2%, the rate of good functional outcome (mRS 0–2) at 90 days was 55.4%, and the all-cause mortality rate at 90 days was 14.4%. No device-related serious adverse events (SAEs) occurred. Procedure-related SAEs occurred in 9 patients (5.4%) within 24 h and in 12 patients (7.2%) overall. The rate of successful revascularization was higher for patients treated first-line with ADAPT (88.0%) than for patients treated first-line with ADAPT + 3D (75.0%; p = 0.035); no significant difference was observed between the ADAPT and ADAPT + 3D groups for any other primary or secondary outcome.ConclusionFor patients with AIS due to anterior circulation LVO and with late onset to treatment, aspiration thrombectomy with the Penumbra System appears to be safe and effective. The rates of good functional outcome and all-cause mortality from this study compared favorably with those rates from the medical management arms of the DAWN and DEFUSE-3 studies.Clinical trial registrationhttps://www.clinicaltrials.gov, NCT03464565.
Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit from WWOX tumor suppressor expression
Authors: Kałuzińska-Kołat Żaneta , Kołat Damian , Kośla Katarzyna , Płuciennik Elżbieta , Bednarek Andrzej K. 
Published: September 2023

IntroductionGlioblastoma (GBM) is notorious for its clinical and molecular heterogeneity, contributing to therapeutic failure and a grim prognosis. WWOX is one of the tumor suppressor genes important in nervous tissue or related pathologies, which was scarcely investigated in GBM for reliable associations with prognosis or disease progression despite known alterations. Recently, we observed a phenotypic heterogeneity between GBM cell lines (U87MG, T98G, U251MG, DBTRG-05MG), among which the anti-GBM activity of WWOX was generally corresponding, but colony growth and formation were inconsistent in DBTRG-05MG. This prompted us to investigate the molecular landscapes of these cell lines, intending to translate them into the clinical context.MethodsU87MG/T98G/U251MG/DBTRG-05MG were subjected to high-throughput sequencing, and obtained data were explored via weighted gene co-expression network analysis, differential expression analysis, functional annotation, and network building. Following the identification of the most relevant DBTRG-distinguishing driver genes, data from GBM patients were employed for, e.g., differential expression analysis, survival analysis, and principal component analysis.ResultsAlthough most driver genes were unique for each cell line, some were inversely regulated in DBTRG-05MG. Alongside driver genes, the differentially-expressed genes were used to build a WWOX-related network depicting protein–protein interactions in U87MG/T98G/U251MG/DBTRG-05MG. This network revealed processes distinctly regulated in DBTRG-05MG, e.g., microglia proliferation or neurofibrillary tangle assembly. POLE4 and HSF2BP were selected as DBTRG-discriminating driver genes based on the gene significance, module membership, and fold-change. Alongside WWOX, POLE4 and HSF2BP expression was used to stratify patients into cell lines-resembling groups that differed in, e.g., prognosis and treatment response. Some differences from a WWOX-related network were certified in patients, revealing genes that clarify clinical outcomes. Presumably, WWOX overexpression in DBTRG-05MG resulted in expression profile change resembling that of patients with inferior prognosis and drug response. Among these patients, WWOX may be inaccessible for its partners and does not manifest its anti-cancer activity, which was proposed in the literature but not regarding glioblastoma or concerning POLE4 and HSF2BP.ConclusionCell lines data enabled the identification of patients among which, despite high expression of WWOX tumor suppressor, no advantageous outcomes were noted due to the cancer-promoting profile ensured by other genes.
The psoas muscle density as a predictor of postoperative complications in elderly patients undergoing rectal cancer resection
Authors: Xiao Yun-Zhou , Wen Xiao-Ting , Ying Ying-Ying , Zhang Xiao-Yan , Li Lu-Yao , Wang Zhong-Chu , Su Miao-Guang , Zheng Xiang-Wu , Miao Shou-Liang 
Published: September 2023

BackgroundMuscle depletion that impairs normal physiological function in elderly patients leads to poor prognosis. This study aimed to evaluate the association between total abdominal muscle area (TAMA), total psoas area (TPA), psoas muscle density (PMD), and short-term postoperative complications in elderly patients with rectal cancer.MethodsAll elderly patients underwent rectal cancer resection with perioperative abdominal computed tomography (CT). Complications were assessed according to the Clavien-Dindo classification. Severe complications were defined as grade III-V following the Clavien-Dindo classification. Univariate and multivariate analyses were performed to evaluate risk factors of short-term severe postoperative complications.ResultsThe cohort consisted of 191 patients with a mean age of 73.60 ± 8.81 years. Among them, 138 (72.25%) patients had Clavien-Dindo 0- II, 53 (27.75%) patients had severe postoperative complications (Clavien-Dindo III-V), and 1(0.52%) patient died within 30 days of surgery. PMD was significantly higher in the Clavien-Dindo 0-II cohort compared to the Clavien-Dindo III-V cohort (p=0.004). Nevertheless, TAMA and TPA failed to exhibit significant differences. Moreover, the multivariate regression analysis implied that advanced age [OR 1.07 95%CI (1.02–1.13) p=0.013], male [OR 5.03 95%CI (1.76-14.41) p=0.003], high charlson comorbidity index (CCI) score [OR 3.60 95%CI (1.44-9.00) p=0.006], and low PMD [OR 0.94 95%CI (0.88-0.99) p=0.04] were independent risk factors of Clavien-Dindo III-V.ConclusionPreoperative assessment of the PMD on CT can be a simple and practical method for identifying elderly patients with rectal cancer at risk for severe postoperative complications.
Effectiveness and safety of oral anticoagulants for non-valvular atrial fibrillation: a population-based cohort study in primary healthcare in Catalonia
Authors: Giner-Soriano Maria , Ouchi Dan , Vives Roser , Vilaplana-Carnerero Carles , Molina Andrea , Vallano Antoni , Morros Rosa 
Published: September 2023

Objectives: Our objective was to analyse effectiveness and safety of oral anticoagulants (OAC) for stroke prevention in non-valvular atrial fibrillation.Material and methods: Population-based cohort study including adults initiating oral anticoagulants, either direct oral anticoagulants (DOAC) or vitamin K antagonists (VKA), during 2011–2020.Data source: SIDIAP, capturing information from the electronic health records of Primary Health Care in Catalonia, Spain.Study outcomes: stroke, cerebral and gastrointestinal (GI) haemorrhage, assessed by patients’ subgroups according to different clinical characteristics.Results: We included 90,773 patients. Male sex, older than 75, previous event, peripheral artery disease, deep vein thrombosis, or receiving antiplatelets, antidiabetics or proton pump inhibitors (PPI) was associated with higher stroke risk. For DOAC-treated, treatment switch increased stroke risk, while being adherent had a protective effect. Men, antidiabetic treatment or a previous event increased the risk of cerebral bleeding. Receiving direct oral anticoagulants had a protective effect in comparison to vitamin K antagonists. For DOAC-treated, treatment switch increased, and adherence decreased the bleeding risk. Men, people with chronic kidney disease or a previous event posed an increased risk of gastrointestinal bleeding, whereas receiving PPI had a protective effect. For DOAC-treated, switch was associated with a higher bleeding risk.Conclusion: Being men, a previous event and DOAC-switch posed a higher risk for all study outcomes. direct oral anticoagulants had a protective effect against cerebral bleeding in comparison to vitamin K antagonists. Adherence to direct oral anticoagulants resulted in lower risk of stroke and cerebral bleeding. We found no differences in the risk of stroke and gastrointestinal bleeding when we compared direct oral anticoagulants vs. vitamin K antagonists.
The effect of basic psychological needs on the flow experience in a digital gamified learning setting
Authors: Lüking Sarah , Wünsche Sarah , Wilde Matthias 
Published: September 2023

IntroductionDigitalization and gamification offer numerous motivation-enhancing opportunities to design biology lessons. For example, digital, gamified learning settings can enhance lessons by offering intense experiences. Such lessons might offer the opportunity to witness flow during the learning activity. For learners, flow can be positively influenced by perceived autonomy, competence, and relatedness. However, previous research on biology lessons has not focused on the impacts of the basic need satisfaction on the flow experience in digital learning settings.MethodsTo address this research gap, using the topic of the locomotion systems of animals, we investigated students’ perceived autonomy, competence, and relatedness as possible predictors of their flow experience while processing a digital, gamified learning environment. The teaching unit was thematically focused on the locomotion system of animals. Our sample consisted of 161 students (46.6% female) from sixth to eighth grade. Students’ perceived satisfaction of their basic needs and their flow experience were evaluated.Results and DiscussionResults confirmed perceived autonomy and perceived competence as predictors of students’ flow experience. However, perceived relatedness had no impact on the flow experience. Our findings are in line with the current state of research and prove to be mostly consistent with previous results.