bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical stimulation of mitochondria reduces blood glucose levels
Authors: Powner Michael B , Jeffery Glen 
Published: August 2023

Abstract
Mitochondria regulate metabolism, but solar light influences its rate. Red light increases mitochondrial membrane potentials and ATP production and may increase glucose demand. Here we show, with a glucose tolerance test, that red light exposure in normal subjects significantly reduces blood sugar levels. A 15 min exposure to 670 nm light, reduced the degree of blood glucose elevation following glucose intake by 27.7%, over 2 h. Maximum glucose spiking was reduced by 5.1%. Decreased blood glucose correlated with increased exhaled end-tidal CO2 partial pressure at 1 h, indicating the mechanism includes an increased oxidation rate. Consequently, 670 nm light exposure can be used to reduce blood glucose spikes following meals. This may reduce damaging fluctuations of blood glucose on the body, a major risk factor for diabetic complications, offering a safe, non-invasive intervention for glucose management of diabetes at home.
Hypodense thymic lesions in Hodgkin Lymphoma
Authors: Damek Adrian , Kurch Lars , Franke Friedrich , Attarbaschi Andishe , Beishuizen Auke , Cepelova Michaela , Ceppi Francesco , Daw Stephen , Dieckmann Karin , Fernández-Teijeiro Ana , Feuchtinger Tobias , Flerlage Jamie , Fosså Alexander , Georgi Thomas , Hasenclever Dirk , Hraskova Andrea , Karlen Jonas , Klekawka Tomasz , Kluge Regine , Körholz Dieter , Landman-Parker Judith , Leblanc Thierry , Mauz-Körholz Christine , Metzler Markus , Pears Jane , Steglich Jonas , Uyttebroeck Anne , Vordermark Dirk , Wallace William , Wohlgemuth Walter , Stoevesandt Dietrich 
Published: August 2023

Abstract
Hypodense volumes (HDV) in mediastinal thymic lesions can be visualized in a computed tomography scan in Hodgkin lymphoma.
We analyzed staging CT scans of 1178 patients with mediastinal involvement from the EuroNet-PHL-C1 trial and explored correlations of HDV with patient characteristics, mediastinal tumor volume and progression-free survival.
HDV occurred in 350 of 1178 patients (29.7%), typically in larger mediastinal volumes. There were different patterns in appearance with single lesions found in 243 patients (69.4%), multiple lesions in 107 patients (30.6%). Well delineated lesions were found in 248 cases (70.1%), diffuse lesions were seen in 102 cases (29.1%).
Clinically, B symptoms occurred more often in patients with HDV (47.7% compared to 35.0% without HDV (p=0.039)) and patients with HDV tended to be in higher risk groups. Inadequate overall early-18F-FDG-PET-response was strongly correlated with the occurrence of hypodense lesions (p<0.001).
Patients with total HDV > 40ml (n=80) had a 5-year PFS of 79.6% compared to 89.7% (p=0.01) in patients with HDV < 40ml or no HDV. This difference in PFS is not caused by treatment group alone.
HDV is a common phenomenon in HL with mediastinal involvement Further research should be considered for validation as an independent prognostic factor for PFS.
Long-term outcome after Sphinkeeper ® surgery for treating fecal incontinence – who are good candidates?
Authors: Dawoud Christopher , Widmann Kerstin Melanie , Pereyra David , Harpain Felix , Riss Stefan 
Published: August 2023

Abstract
Purpose: The long-term effect of the novel Sphinkeeper® procedure for treatment of faecal incontinence (FI) still remains unknown.
This study aimed to assess long-term functional outcomes after Sphinkeeper® surgery. Parameters of subjective and objective treatment success and the effect of prostheses dislocation were analysed.
Methods: The study was conducted at a tertiary referral center between August 2018 and September 2021 including 32 patients with FI (28 female and 4 male).
Functional outcome and quality of life were assessed using validated questionnaires before surgery, after 3, 6, 12 months and at the last follow-up appointment. Endo-anal ultrasound and anal manometry were conducted prior to Sphinkeeper® implantation and postoperatively.
Results: The mean follow-up time was 22.62 ± 8.82 months. 53.8% of patients reported having a symptom relief of at least 50% at the last follow-up. St. Mark's incontinence score decreased significantly after surgery (last follow-up visit: p=0.001). Similarly, physical Short Form health survey significantly improved after Sphinkeeper® implantation (p=0.011).
Patients with a higher degree of internal sphincter defect showed an improved objective therapy sucess (r=0.633, p=0.015) after Sphinkeeper® operation, whereas the type and severity of FI had no impact on the functional outcome. Notably, a higher number of dislocated prostheses (r=0.772, p=0.015) showed a significant correlation with reduced improvement of incontinence.
Conclusion: The Sphinkeeper® procedure showed a significant long-term functional improvement in over half of the enrolled patients. Patients with a higher internal sphincter defect benefited most from the Sphinkeeper® operation. Dislocation of the prostheses was associated with less favourable results.
Outcome after neck dissection – a single center cohort study
Authors: Molnár Krisztina , Käkilehto Sanni , Liisanantti Janne , Koivunen Petri , Kaakinen Timo , Nurkkala Juho , Lahtinen Sanna 
Published: August 2023

Abstract
Background
Postoperative complications and their impact on long-term outcome after neck dissection are not well studied. We wanted to assess postoperative complications and long-term survival in this patient group.
Methods
A total of 196 procedures were reviewed from the medical records among patients undergoing neck dissection between years 2014-2019. Medical and surgical complications as well as 5 years survival were recorded and evaluated postoperatively.
Results
A total of 42 (21.4%) surgical and 30 (15.3%) medical complications were recorded. In Cox regression, ASA classification > 2 (OR 2.92 (1.23-3.92) P=0.008) HR 1.97 (1.05-3.70)), pre- or postoperative irradiation (OR 2.21 (1.28 - 3.82) P=0.004. and medical complications (OR 2.45 (1.33 - 4.51) P=0.004) HR 1.92 (1.02-3.61)) were associated to 5-year mortality.
Conclusion
Medical complications and five-year mortality after neck dissection were associated with patients` chronic medical conditions.
Efficiency Droop Free UV-C LED by introducing p-doped LQB and p- n-p-n-p doped AlGaN Hole Injection Layer
Authors: Mazumder Indrani , Sapra Kashish , Chauhan Ashok , Mathew Manish , Singh Kuldip 
Published: August 2023

Abstract
The photosensitive and electrical characteristics of almost efficiency-droop-free UV-C LEDs with a Mg-doped LQB and Si-doped shallow periodic electron injection layer in between Mg-doped EBL and Hole injection layer are studied numerically in order to enhance the optical and electrical performance. SiLENSe software is used to look into the QB-QWs region's IQE, energy band profiles, electron and hole concentration, and radiative recombination rates. The findings show that the proposed UV-C LED has peak IQE 140% higher than the reference one, which is generally related to the improvement of electron and hole function overlapping in QB-QWs region. The proposed modification would decrease hole barrier depth by 64% in LQB-EBL, which is what causes the 190% better hole injection from Mg-doped layer.
On Implementing Stabilizing Leader Election with Weak Assumptions on Network Dynamics † ‡
Authors: Altisen Karine , Devismes Stéphane , Durand Anaïs , Johnen Colette , Petit Franck 
Published: August 2023

Abstract
We consider self-stabilization and its weakened form called pseudo-stabilization. We study conditions under which (pseudo- and self-) stabilizing leader election is solvable in networks subject to frequent topological changes. To model such an high dynamics, we use the dynamic graph (DG) paradigm and study a taxonomy of nine important DG classes. Our results show that self-stabilizing leader election can only be achieved in the classes where all processes are sources. Furthermore, even pseudo-stabilizing leader election cannot be solved in all remaining classes, except in the class where at least one process is a timely source. We illustrate this result by proposing a pseudo-stabilizing leader election algorithm for the latter class. We also show that in this last case, the convergence time of pseudo-stabilizing leader election algorithms cannot be bounded. Nevertheless, we show that our solution is speculative since its convergence time can be bounded when the dynamics is not too erratic, precisely when all processes are timely sources.
MSC Classification: 68W15 68M15
Accounting for variety
Authors: Winkler Julian 
Published: August 2023

Abstract
I introduce a general method to account for the distribution of underlying components (variety) in the growth of an aggregate quantity, using the notion of entropy. This accounting decomposition enables a number of insightful applications to index numbers in economics. The cross-entropy of GDP with respect to a benchmark captures the change in its distribution, and thus how well this benchmark matches data for price and volume indices across time. This 'error' changes demonstrably over time. Accounting of variety also lends itself to a decomposition of labour productivity growth by a technology component (how many more 'average' goods are produced per unit of labour?), and the allocation of labour (does the distribution of labour inputs converge to the distribution of outputs?) plus demand (does the distribution of expenditures diverge from the distribution of outputs?).
Examining the Effect of Painting Art on Student Well-Being and the Design Principles of Public Art on Campus
Authors: Huang Lanqing , Zhang Lingyan ,   Cheng Yao1, Ying Fangtian 
Published: August 2023

Abstract

Painting as an art form has the potential to evoke positive emotions and enhance students' well-being. Integrating it into campus art can improve public spaces and cultivate happiness among students. The study aims to explore sketch art's impact on students' happiness and propose adaptable design principles for 3D art on campus. Results indicate artists can effectively use cognitive and visual aspects to create exceptional artworks that harmonize with the campus environment, ultimately elevating student happiness. Further research is recommended to explore how campus art promotes public space development, enhances campus culture, and stimulates student happiness, providing valuable guidance to artists for creating high-quality campus art.
New Constructions of Two-Dimensional Binary Z-Complementary Array Sets with Large Zero Correlation Zone Width
Authors: xie chunlei , Li Chenrui , Sun Yu , Heng Ziling , Ming Yang 
Published: August 2023

Abstract

The one-dimensional (1-D) Z-complementary sequence set (ZCSS) has been widely employed in communications engineering. The concept of 1-D ZCSS can be extended to the two-dimensional (2-D) Z-complementary array set (ZCAS) where the 2-D aperiodic autocorrelations of constituent arrays sum to zero for the 2-D certain shifts.2-D ZCASs play an important role in radar, 2-D multi-carrier code-division multiple access (MC-CDMA) systems, multiple-input and multiple-output (MIMO) systems, ultra wideband communication systems, etc.In this paper, we focus on designing new 2-D ZCASs by using Boolean functions and concatenation.We first present a direct construction of (2k,2k,2n,142m,2n,122m)-ZCASs by employing Boolean functions.The constructed ZCASs have the largest known zero correlation zone (ZCZ) width and low peak to-mean envelope power (PMEPR).Next, we provide a class of 2-D ZCASs with ZCZ around the end-shift position by using concatenation, which have new lengths and large ZCZ widths.
Is it beneficial for patients with early breast cancer after mastectomy to receive internal mammary node irradiation? A propensity-matched analysis of a retrospective cohort
Authors: Xie Yuxin , Gou Qiheng , Zhang Yingjie 
Published: August 2023

Abstract
Background The association between internal mammary lymph node irradiation (IMNI) and survival in patients with early-stage breast cancer is currently controversial.
Objective We examined the effect of IMNI in patients treated with mastectomy and systemic treatment in China.
Methods We analyzed women with early-stage breast cancer who underwent mastectomy followed by adjuvant chest wall and regional lymph node irradiation (RNI) from the Breast Cancer Information Management System (BCIMS). We analyzed women with early-stage breast cancer who underwent mastectomy followed by adjuvant chest wall and regional lymph node irradiation (RNI) from the BCIMS. Patients were categorized into two groups: those who received IMNI and those who received no IMNI. Disease-free survival (DFS) was the primary endpoint. Cox proportional hazards models and propensity score-matching methods were used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) and to minimize bias.
Results In accordance with the study inclusion and exclusion criteria, a total of 1,015 patients were included, of whom 189 received adjuvant irradiation with IMNI and 826 received no IMNI. After propensity score matching, baseline characteristics were well-balanced between the two groups. During a median follow-up of 8.9 years, patients treated with IMNIfailed to achieve a better DFS (HR, 0.36; 95% CI, 0.13–0.99; P = 0.04) compared with those treated without IMNI after adjusting for confounders. Subtype analysis further showed that there was an elevated association between IMNI and decreased DFS.
Conclusion In China, our findings suggest that the inclusion of IMNs in the RNI protocol aftermastectomy has no survival benefit over twenty decades ago and needs to be carefully considered. Randomized studies are required to further confirm the influence of IMNI on prognosis.
Multi-Agent Cooperative Game Based Task Computing Mechanism for UAV-Assisted 6G NTN
Authors: Shao Sujie , Su Lili , Guo Shaoyong , Yu Peng , Qiu Xuesong 
Published: August 2023

Abstract
Unmanned Aerial Vehicle (UAV)-Assisted becomes promising prospects for the development of 6G non-terrestrial networks (NTN) due to their low cost, low latency, flexible coverage, and support for emergency response. UAVs utilize close-range multi-point cooperative computing to provide computational, storage, and communication resources for 6G NTN. However, insufficient resources and variable business requirements can lead to node overload or task timeout. Therefore, selecting collaborative nodes and optimizing data transmission paths between non-terrestrial nodes has become a formidable challenge. Due to the capacity constraints, power limitations, time-varying communication links, and increasing terminal demands, existing algorithms face difficulties in meeting the requirements of cooperative computing for nonterrestrial nodes. To solve the issue, this paper proposes a multi-task cooperative computing mechanism that focuses on node selection and path optimization. Furthermore, node selection and path optimization algorithm based on multiagent proximal policy optimization (NSPO-MAPPO) is designed to optimize the latency-aware multi-task cooperative computing objective, thereby improving computational task execution efficiency and service quality. Experimental comparisons with other algorithms demonstrate the effectiveness of our method in minimizing latency, enhancing task load balancing, and ensuring stable and reliable cooperative computing services for non-terrestrial nodes.
Fabricated of Bio-Filter to Improve Drainage Water
Authors: Sehsah Elsayed 
Published: August 2023

Abstract
The aim of the current research is to manufacture a bio-filter to improve the usage of drainage water and assess the added value of applying the low-cost rice straw filter in achieving higher water productivity, a cleaner product, and a cleaner environment, as well as reducing waste loads in water and improving water use efficiency. The laboratory unit test consisted of two main plastic tanks, a hydraulic centrifugal pump with 0.736 kW (1 hp), mechanical valves, a water tap flow instrument, pipes line, a pressure gauge manometer, and a rice straw filter. The first tank with a capacity of 100 liters of plastic material was used to collect the wastewater. The quality parameters for control pad fish water values before treatment were 478 mg/L, 305.9 mg/L, 156 mg/L, and 487 mg/L for COD, BOD, TDS, and TSS, respectively. The quality parameters for pad fish values after using the rice straw filter treatment were 34 mg/L, 22.2 mg/L, 21 mg/L, and 316 mg/L for COD, BOD, TDS, and TSS, respectively. The NH3 value for control wastewater was 10.4 mg/L compared to 7.12 mg/L, 6.8 mg/L, and 6 mg/L after using the developed rice straw filter at retention time 30 min, 45 min, and 60 min, respectively. Additionally, the maximum reduction of the COD, BOD, TDS, and TSS values was 85.58%, 85.82%, 79.75%, and 46.46% for using the manufactured cleaning unit with the developed rice straw filter, respectively.
An analysis of the convergence problem of a function in functional norms by applying the product Hausdorff operator
Authors: Swagata Swagata Nandy 
Published: August 2023

Abstract
In this study, we have obtained results regarding the convergence properties of a function of derived conjugate Fourier series in weighted Lipschitz and generalized Holder spaces. These results were obtained by utilizing the product Hausdorff operator. Several intriguing applications of our findings are also examined to observe the convergence behaviour of the function in the aforementioned spaces.
2010 MSC: 41A10, 42A10, 42B05.
Factors associated with the failure to achieve door to balloon time ≤90 minutes in patients with ST-segment elevation myocardial infarction in an electrocardiogram triage system: a retrospective observational study
Authors: Inoue Atsuhito , Mizobe Michiko , Takahashi Jin , Funakoshi Hiraku 
Published: August 2023

Abstract
Background
Door to balloon time is a crucial factor of mortality in patients with ST-segment elevation myocardial infarction. However, the factors that contribute to failure of achieving door to balloon time ≤90 minutes in an electrocardiogram triage system remain unknown.
Methods
This single-center retrospective observational study collected data from consecutive patients with ST-segment elevation myocardial infarction from April 2016 to March 2021. The primary outcome was the failure to achieve door to balloon time ≤90 minutes. A multivariate logistic regression model was performed to predict factors associated with failure to achieve door to balloon time ≤90 minutes.
Results
In total, 190 eligible patients were included. Of these, the 139 (73.2%) patients with door to balloon time ≤90 minutes were significantly younger compared to those with door to balloon time >90 minutes (p=0.02). However, there was no significant difference in sex and timing of hospital arrival between the door to balloon time ≤90 and >90 minutes groups. Presence of chest pain and ambulance usage were significantly more frequent in patients with door to balloon time ≤90 minutes (p≤0.01, p=0.02, respectively). Multivariate analysis showed that absence of chest pain (adjusted odds ratio 4.76; 95% confidence interval, 2.04-11.1; p<0.01) and non-ambulance usage (adjusted odds ratio 3.53; 95% confidence interval, 1.57-7.94; p<0.01) are predictive factors of failure to achieve door to balloon time ≤90 minutes.
Conclusion
Patients without chest pain as the chief complaint or non-ambulance usage were significantly associated with the failure to achieve door to balloon time ≤90 minutes.
Action and Interaction of Amyloid-β and Insulin on the Dopamine Release and Reuptake in the Lateral Dorsal Striatum of Rats
Authors: Mukhin Valery N. , Borovets Ivan R. , Sizov Vadim V. , Klimenko Victor M. 
Published: August 2023

Abstract
Accumulation of amyloid-β (Aβ) in the brain is an important link in the pathogenesis of Alzheimer's disease. Experimental studies show that Aβ can cause the dopaminergic dysfunction that is characteristic of this disease, and under Aβ influence not only the decrease but also the increase in phasic dopamine release is possible, depending on the structure of the brain. We aimed to investigate whether Aβ in a toxic form affects dopamine release or reuptake in the lateral dorsal striatum and, if so, whether this influence is mediated by the insulin signaling pathway. Aβ (fragment 25-35) and insulin solution were injected into the ventricular system of the anesthetized male Wistar rats. Within 10 minutes before and 30 minutes after the injection, electrically evoked dopamine elevations were registered with fast-scan cyclic voltammetry every 5 minutes. Release and reuptake were assessed separately by the kinetic analysis. The results show that Aβ acts on dopamine release and reuptake in the lateral dorsal striatum in several ways. It modulates the effect of insulin on dopamine release and reuptake, apparently acting through the insulin signaling pathway. In addition, Aβ increases dopamine release and basal levels by acting aside of the insulin signaling pathway.
Mixed methods usability evaluation of an assistive wearable robotic hand orthosis for people with spinal cord injury
Authors: Dittli Jan , Meyer Jan Thomas , Gantenbein Jessica , Bützer Tobias , Ranzani Raffaele , Linke Anita , Curt Armin , Gassert Roger , Lambercy Olivier 
Published: August 2023

Abstract
Background Robotic hand orthoses (RHO) aim to provide grasp assistance for people with sensorimotor hand impairment during daily tasks. Many of such devices have been shown to bring a functional benefit to the user. However, assessing functional benefit is not sufficient to evaluate the usability of such technologies for daily life application. A comprehensive and structured evaluation of device usability not only focusing on effectiveness but also efficiency and satisfaction is required, yet often falls short in existing literature. Mixed methods evaluations, i.e., assessing a combination of quantitative and qualitative measures, allow to obtain a more holistic picture of all relevant aspects of device usability. Considering these aspects already in early development stages allows to identify design issues and generate generalizable benchmarks for future developments.
Methods We evaluated the short-term usability of the RELab tenoexo, a RHO for hand function assistance, in 15 users with tetraplegia after a spinal cord injury through a comprehensive mixed methods approach. We collected quantitative data using the Action Research Arm Test (ARAT), the System Usability Scale (SUS), and timed tasks such as the donning process. In addition, qualitative data were collected through semi-structured interviews and user observations, and analyzed with a thematic analysis to enhance the usability evaluation. All insights were attributed and discussed in relation to specifically defined usability attributes such as comfort, ease of use, functional benefit, and safety.
Results The RELab tenoexo provided an immediate functional benefit to the users, resulting in a mean improvement of the ARAT score by 5.8 points and peaking at 15 points improvement for one user (clinically important difference: 5.7 points). The mean SUS rating of 60.6 represents an adequate usability, however, indicating that especially the RHO donning (average task time = 295s) was perceived as too long and cumbersome. The participants were generally very satisfied with the ergonomics (size, dimensions, fit) of the RHO. Increasing the ease of use, specifically in donning, as well as the need for tailoring options and customization were identified as main improvement areas to promote RHO usability.
Conclusion The short-term usability of the RELab tenoexo was thoroughly evaluated with a mixed methods approach, which generated valuable data to improve the RHO in future iterations. In addition, learnings that might be transferable to the evaluation and design of other RHO were generated, which have the potential to increase the daily life applicability and acceptance of similar technologies.