bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemberdayaan Pelaku Seni Jaranan Nganjuk Dalam Menangani Cidera Melalui Keterampilan Masase Terapi
Authors: Sifa Agus , Hariyanto Agus , Suryandoko Welly 
Published: December 2022

Pengabdian Kepada Masyarakat yang berjudul Pemberdayaan Pelaku Seni Jaranan Nganjuk Dalam Menangani Cidera Melalui Keterampilan Masase Terapi memiliki tujuan mendasar penerapan pada masyarakat yaitu mensejahterahkan dengan selalu menjaga kesehatan dengan cara menjaga kondisi fisik. Para pelaku Jaranan perlu diperdayakan agar taraf hidup dan daya hidup lebih baik. Maka, melalui pengabdian ini dapat memberikan kontribusi yang baik, sebab tujuan utama dilaksanakan pengabdian ini adalah agar pelaku dapat mandiri dalam mengatasi cidera ringan maupun cidera berat pada saat atau setelah pertunjukan. Pemberdayaan dilakukan dalam bentuk 1) Keterlibatan mitra sebagai peserta pelatihan masase terapi pada cidera, 2) Terlibat dalam penanganan cidera melalui keterampilan masase terapi, 3) Melibatkan pelaku Jaranan lainnya untuk diberdayakan agar memiliki keterampilan masase terapi, 5) Keterlibatan dalam membentuk kelompok masase terapi untuk para pelaku Jaranan. Tujuan utamanya agar pelaku Seni Jaranan memahami manfat, teknik dan praktik masase terapi ini. Berikutnya adalah dengan memberikan legitimasi untuk pelaku Jaranan yang mahir melakukan masase terapi berupa sertifikasi bahwa pelaku Seni Jaranan masing-masing telah memiliki keterampilan dalam menangani pemain Jaranan saat mengalami cidera.
Kata kunci: Seni Jaranan; Cidera; Masase Terapi
Transfigurasi Komunikasi Visual pada Corak Motif Batik Pamekasan Madura
Authors: Triandika Lulus , Dewi Danar Kristiana 
Published: December 2022

Sebagai warisan budaya, Batik Madura memiliki nilai sejarah dan filosofi yang mendalam. Kabupaten Pamekasan sebagai daerah penghasil batik di Madura senantiasa mempertahankan corak motifnya secara turun-temurun selama ratusan tahun. Namun pengaruh perkembangan kondisi sosial dan budaya ternyata memberikan pengaruh pada batik Pamekasan. Terutama pada corak motifnya, secara umum Batik Pamekasan menggunakan figur tumbuhan dan binatang dalam corak motifnya. Namun, secara detail pengaruh perkembangan sosial dan budaya terlihat dalam corak motif batik Pamekasan. Termasuk pengaruh figur selain tumbuhan dan binatang yang menjadi inspirasi pembuatan corak motif batik. Corak motif batik menarik untuk dikaji sebagai sebuah produk
budaya yang seharusnya mempertahankan tata aturan leluhur. Meskipun telah banyak kajian tentang batik, namun masih sedikit tentang corak motif dalam batik. Terlebih kajian tentang corak motif batik Pamekasan Madura dari perspektif komunikasi visual. Sehingga menarik untuk dikaji lebih dalam guna mengetahui perkembangan dalam corak motif batik Pamekasan. Penelitian ini menggunakan metode diskriptif kualitatif, dengan teknik pengumpulan data melalui observasi, studi literatur, dan hasil wawancara dengan narasumber. Analisis Semiotika visual Charles Sanders Peirce dipakai guna mengkaji objek penelitian yakni corak motif batik. Kemudian diambil kesimpulan berdasar analisis data.
A hybrid system for the overproduction of complex ergot alkaloid chanoclavine
Authors: Ma Yaqing , Yan Juzhang , Yang Lujia , Yao Yongpeng , Wang Luoyi , Gao Shu-Shan , Cui Chengsen 
Published: December 2022

Synthetic biology-based methods (Sbio) and chemical synthesis (Csyn) are two independent approaches that are both widely used for synthesizing biomolecules. In the current study, two systems were combined for the overproduction of chanoclavine (CC), a structurally complex ergot alkaloid. The whole synthetic pathway for CC was split into three sections: enzymatic synthesis of 4-Br-Trp (4-Bromo-trptophan) using cell-lysate catalysis (CLC), chemical synthesis of prechanoclavine (PCC) from 4-Br-Trp, and overproduction CC from PCC using a whole-cell catalysis (WCC) platform. The final titer of the CC is over 3 g/L in this Sbio-Csyn hybrid system, the highest yield reported so far, to the best of our knowledge. The development of such a combined route could potentially avoid the limitations of both Sbio and Csyn systems and boost the overproduction of complex natural products.
Lead-vanadate sorbents for iodine trapping and their conversion into an iodoapatite-based conditioning matrix
Authors: Pénélope R. , Campayo L. , Fournier M. , Le Gallet S. , Gossard A. , Grandjean A. 
Published: December 2022

New lead-vanadate based sorbents were synthesized with the aim to entrap and confine gaseous iodine in off-gas streams coming from reprocessing facilities of spent nuclear fuel. Their synthesis relies on the shaping of a lead-vanadate, lead sulfide and alginic acid mix as millimetric beads. These beads were calcined between 220°C and 500°C to remove organic alginic compounds template. However, according to the calcination temperature, lead sulfide could be partially oxidized, limiting iodine loading capacity. A compromise temperature between 290°C and 350°C was found to remove most of the alginic acid template and avoiding lead sulfide oxidation. These sorbents were tested for iodine trapping in static conditions at 60°C. They performed well with a sorption capacity up to 155 mg.g−1 by forming PbI2. Furthermore, these iodine-loaded sorbents could be easily converted into an iodine-containing lead-vanadate apatite matrix by spark plasma sintering. A dense sample was produced for a sintering temperature of 500°C under 70 MPa. Such a material could be suitable for radioactive iodine conditioning in deep geological disposal. Finally, lead-vanadate sorbents could provide an easy way to entrap and confine radioactive iodine from off-gas streams into a durable material within a few steps.
Pulmonary fibrosis in patients with COVID-19: A retrospective study
Authors: Li Fanglin , Deng Jiayi , Song Yongqiang , Wu Chenfang , Yu Bo , Wang Guyi , Li Jinxiu , Zhong Yanjun , Liang Fang 
Published: December 2022

BackgroundCoronavirus disease 2019 (COVID-19) pandemic has caused substantial threats to people’s physical health and lives, claiming the lives of over 6 million people worldwide. Although the mortality rate of COVID-19 is very low, many survivors may have different degrees and various sequelae. Previous studies have shown that pulmonary fibrosis (PF) were common on discharged COVID-19 patients, and PF itself is a poor prognostic factor.Methods227 COVID-19 hospitalized patients’ clinical and laboratory data from the first 15 days following admission were collected in this retrospective study. Groups were based on with or without PF of COVID-19. Categorical variables were compared with the chi-square test or Fisher’s exact test. Continuous variables were tested by Wilcoxon rank-sum test for the non-normal distribution. Spearman correlations were used to assess the correlations between PF with clinic parameters of multiple time points. Univariate and multivariate logistic regression were used to analyze for risk factors of COVID-19 patients with pulmonary fibrosis.ResultsSixty cases of COVID-19 patients were diagnosed with PF. Compared with 167 non-PF patients, those with PF were older and had higher proportions of fever, shortness of breath, hemoptysis, abdominal pain, hypertension, cardiovascular, diabetes, high flow nasal cannula (HFNC), severe disease, and virus shedding duration. Furthermore, the correlation analysis between PF and clinic parameters showed that PF were positively related to the C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and negatively correlated with hemoglobin (HGB) and albumin (ALB) at all time points in the first 15 days after admission. Moreover, We found that PF were significantly correlated with coagulation indexes prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fib) and fibrinolysis index D-Dimer at some phases. In addition, Univariate logistic regression analyses showed that age, fever, shortness of breath, hemoptysis, hypertension, cardiovascular, diabetes, HFNC, severe disease were the risk factors of COVID-19 patients with PF. However, multivariate logistic regression showed that age was the risk factor of COVID-19 patients with PF.ConclusionCombining various factors, advanced age is an independent risk factor of COVID-19 patients with PF. PF was significantly related with clinic parameter of inflammation/coagulopathy/fibrinolysis.
Rotational atherectomy for chronically and totally occluded coronary lesions: A propensity score-matched outcomes study
Authors: Tsai Tien-Chien , Lo Wei-Jung , Chen Wei-Jhong , Lai Chih-Hung , Su Chieh-Shou , Chang Wei-Chun , Wang Chi-Yen , Liu Tsun-Jui , Liang Kae-Woei , Lee Wen-Lieng , Chen Yu-Wei 
Published: December 2022

BackgroundDespite advances being made in techniques and devices, certain chronic total occlusion (CTO) lesions remain uncrossable or undilatable. Rotational atherectomy (RA) is usually necessary for such lesions to achieve successful revascularization.MethodsInformation regarding consecutive patients who underwent coronary RA was retrieved from the catheterization laboratory database. Patients who underwent RA for CTO lesion refractory using other conventional devices were recruited, with propensity score-matched cases serving as controls.ResultsA total of 411 patients underwent coronary RA in the study period. Most patients had high-risk features (65.7% had acute coronary syndrome (ACS), 14.1% ischemic cardiomyopathy, and 5.1% cardiogenic shock), while only 20.2% of the patients had stable angina. Among them, 44 patients underwent RA for CTO lesions (CTO group), whereas the propensity score matched controls consist of 37 patients (non-CTO group). The baseline characteristics, high-risk features, coronary artery disease (CAD) vessel numbers, left ventricular function and biochemistry profiles of both groups were the same except for more patients with diabetes (67.6% vs. 45.5%, p = 0.046) in the non-CTO group and more 1.25 mm burr uses in the CTO group. There were no significant differences in acute procedural outcomes or incidence of acute contrast-induced nephropathy (CIN), and no patient demanded emergent CABG or died during the procedure. There was no significant difference in major adverse cardiovascular events (MACE), CV MACE or individual components between the two groups in the hospital, at 30, 90, and 180 days or at 1 year.ConclusionIn comparison with the propensity risk factor scores-matched controls, there was no difference in procedural complications, acute CIN or clinical outcomes during various stages of RA for CTO lesions. RA for CTO patients was highly efficient and showed safety and outcome profiles similar to those for non-CTO lesions.
Non-linear relationship between albumin-corrected calcium and 30-day in-hospital mortality in ICU patients: A multicenter retrospective cohort study
Authors: Qin Xun , Cen Ji , Hu Haofei , Chen Xinglin , Wei Zhe , Wan Qijun , Cao Rong 
Published: December 2022

ObjectiveAlbumin-corrected calcium is usually calculated to reflect the real serum calcium level of the whole body by physicians. However, studies on the association between albumin-corrected calcium and 30-day in-hospital mortality in Intensive Care Unit (ICU) patients are rare. The purpose of our study was to explore the association between baseline albumin-corrected calcium and 30-day in-hospital mortality in the American ICU population.MethodsA multicenter retrospective cohort study of 102,245 ICU patients in the eICU-CRD v2.0 from the USA during 2014–2015 was performed. The average age was 63.7 ± 16.9 years, of which 55,313 (53.7%) were men and 47,758 (46.3%) were women. The association between albumin-corrected calcium and 30-day in-hospital mortality was analyzed by Cox proportional-hazards regression, smooth curve fitting, piecewise linear regression, subgroup analyses, and a series of sensitivity analyses.ResultsWe found that among ICU patients with calcium abnormalities, more than 95% were mild hypocalcemia or mild hypercalcemia. The risk of 30-day in-hospital mortality will increase by 10% in the ≥7.5–&lt; 8.5 mg/dl subgroup (OR=1.1, 95% CI 1.0–1.3) or 20% in the ≥10.3–&lt;12 mg/dl subgroup (OR=1.2, 95% CI 1.1–1.3) when the albumin-corrected calcium level increases by 1 mg/dl. Additionally, the relationship between albumin-corrected calcium and 30-day in-hospital mortality was U shaped; the inflection point was 8.9 mg/dl (log likelihood ratio test P = 0.005). Finally, after a series of sensitivity analyses, we found that the relationship between albumin-corrected calcium and 30-day in-hospital mortality remained significant.ConclusionIn a large nationally representative cohort of ICU patients, abnormalities in albumin-corrected calcium, particularly slight hypocalcemia or slight hypercalcemia, were associated with an increased 30-day in-hospital mortality risk, and yet the findings in this study need to be further confirmed by prospective studies.
A bibliometric analysis of NLRP3 inflammasome in acute lung injury/acute respiratory distress syndrome from 2010 to 2021
Authors: Xiao Zhuoran , Hu Song , Xu Wenting , Wang Sheng , Mo Wei , Deng Huimin , Wei Juan , Yang Hao , Zhou Wenyu , Li Quanfu , Zhou Huanping , Lv Xin 
Published: December 2022

BackgroundNod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is essential in the pathogenesis of acute respiratory distress syndrome (ARDS), a fatal clinical syndrome that deteriorated from acute lung injury (ALI). This bibliometric study aims to offer a thorough insight into the scientific output about NLRP3 inflammasome in ALI/ARDS and explore the intellectual base, developing trajectory and emerging trends.MethodsWe retrieved the literature from 2010 to 2021 from Science Citation Index Expanded (SCIE) database. Bibliometrix (3.1.4) R package and CiteSpace (5.8.R3) were used for further analysis and visualization.ResultsA total of 508 English articles and reviews published from 2010 to 2021 were identified. The annual number of publications presented a rapidly developing trend especially in recent years. Among all the 42 countries, China was the most productive and most cited country, while the USA had the greatest impact. Peter A. Ward from the USA was the most productive corresponding author, and 4 of these top 10 corresponding authors were from China. The most cited reference was written by Ahmed (2017) of Zhejiang University in China. The Journal of Immunology had highest citation count and G-index. Furthermore, the major disciplines of research front have drifted from “Medicine, Medical, Clinical” to “Molecular, Biology, Immunology” over the past 12 years. In the co-occurring network, the terms “acute lung injury,” “NLRP3 inflammasome,” “interleukin-1β,” “NF-κB,” and “NLRP3 activation” occurred most frequently, while in burst detection, “oxidative stress” had the highest burst strength. Co-citation network revealed that Cluster 2 “virus infection” was the most active area, including the most citation bursts. Cluster 0 “severe COVID-19” and Cluster 1 “dual inhibitor PTUPB” were emerging themes in recent years, and they involved the largest number of publications.ConclusionsThis bibliometric analysis revealed a rapid growth trend of the relatively novel topic: NLRP3 inflammasome in ALI/ARDS. China was the largest contributor, while the USA offered the most landmark papers. The major disciplines of research front drifted from “Medicine, Medical, Clinical” to “Molecular, Biology, Immunology.” In recent years, studies about the role of NLRP3 in COVID-19-associated ALI/ARDS and oxidative stress became hot spots.
A diagnostic model for predicting type 2 nasal polyps using biomarkers in nasal secretion
Authors: Wang Zaichuan , Wang Qiqi , Duan Su , Zhang Yuling , Zhao Limin , Zhang Shujian , Hao Liusiqi , Li Yan , Wang Xiangdong , Wang Chenshuo , Zhang Nan , Bachert Claus , Zhang Luo , Lan Feng 
Published: December 2022

BackgroundPredicting type 2 chronic rhinosinusitis with nasal polyps (CRSwNP) may help for selection of appropriate surgical procedures or pharmacotherapies in advance. However, an accurate non-invasive method for diagnosis of type 2 CRSwNP is presently unavailable.MethodsTo optimize the technique for collecting nasal secretion (NasSec), 89 CRSwNP patients were tested using nasal packs made with four types of materials. Further, Th2low and Th2highCRSwNP defined by clustering analysis in another 142 CRSwNP patients using tissue biomarkers, in the meanwhile, inflammatory biomarkers were detected in NasSec of the same patients collected by the selected nasal pack. A diagnostic model was established by machine learning algorithms to predict Th2highCRSwNP using NasSecs biomarkers.ResultsConsidering the area under receiver operating characteristic curve (AUC) for IL-5 in NasSec, nasal pack in polyvinyl alcohol (PVA) was superior to other materials for NasSec collection. When Th2low and Th2highCRSwNP clusters were defined, logistic regression and decision tree model for prediction of Th2highCRSwNP demonstrated high AUCs values of 0.92 and 0.90 respectively using biomarkers of NasSecs. Consequently, the pre-pruned decision tree model; based on the levels of IL-5 in NasSec (≤ 15.04 pg/mL), blood eosinophil count (≤ 0.475*109/L) and absence of comorbid asthma; was chosen to define Th2lowCRSwNP from Th2highCRSwNP for routine clinical use.ConclusionsTaken together, a decision tree model based on a combination of NasSec biomarkers and clinical features can accurately define type 2 CRSwNP patients and therefore may be of benefit to patients in receiving appropriate therapies in daily clinical practice.
Predicting the prognosis in patients with sepsis by a pyroptosis-related gene signature
Authors: Liang Shuang , Xing Manyu , Chen Xiang , Peng Jingyi , Song Zongbin , Zou Wangyuan 
Published: December 2022

BackgroundSepsis remains a life-threatening disease with a high mortality rate that causes millions of deaths worldwide every year. Many studies have suggested that pyroptosis plays an important role in the development and progression of sepsis. However, the potential prognostic and diagnostic value of pyroptosis-related genes in sepsis remains unknown.MethodsThe GSE65682 and GSE95233 datasets were obtained from Gene Expression Omnibus (GEO) database and pyroptosis-related genes were obtained from previous literature and Molecular Signature Database. Univariate cox analysis and least absolute shrinkage and selection operator (LASSO) cox regression analysis were used to select prognostic differentially expressed pyroptosis-related genes and constructed a prognostic risk score. Functional analysis and immune infiltration analysis were used to investigate the biological characteristics and immune cell enrichment in sepsis patients who were classified as low- or high-risk based on their risk score. Then the correlation between pyroptosis-related genes and immune cells was analyzed and the diagnostic value of the selected genes was assessed using the receiver operating characteristic curve.ResultsA total of 16 pyroptosis-related differentially expressed genes were identified between sepsis patients and healthy individuals. A six-gene-based (GZMB, CHMP7, NLRP1, MYD88, ELANE, and AIM2) prognostic risk score was developed. Based on the risk score, sepsis patients were divided into low- and high-risk groups, and patients in the low-risk group had a better prognosis. Functional enrichment analysis found that NOD-like receptor signaling pathway, hematopoietic cell lineage, and other immune-related pathways were enriched. Immune infiltration analysis showed that some innate and adaptive immune cells were significantly different between low- and high-risk groups, and correlation analysis revealed that all six genes were significantly correlated with neutrophils. Four out of six genes (GZMB, CHMP7, NLRP1, and AIM2) also have potential diagnostic value in sepsis diagnosis.ConclusionWe developed and validated a novel prognostic predictive risk score for sepsis based on six pyroptosis-related genes. Four out of the six genes also have potential diagnostic value in sepsis diagnosis.
Development and validation of a nomogram for predicting survival time and making treatment decisions for clinical stage IA NSCLC based on the SEER database
Authors: Xu Bingchen , Ye Ziming , Zhu Lianxin , Xu Chunwei , Lu Mingjian , Wang Qian , Yao Wang , Zhu Zhihua 
Published: December 2022

BackgroundThe aim of this study was to establish and validate a nomogram model for accurate prediction of patients’ survival with T1aN0M0 none small cell lung cancer (NSCLC).MethodsThe patients, diagnosed with the stage IA NSCLC from 2004–2015, were identified from the Surveillance, Epidemiology and End Results (SEER) database. The variables with a P-value &lt; 0.05 in a multivariate Cox regression were selected to establish the nomogram. The discriminative ability of the model was evaluated by the concordance index (C-index). The proximity of the nomogram prediction to the actual risk was depicted by a calibration plot. The clinical usefulness was estimated by the decision curve analysis (DCA). Survival curves were made with Kaplan–Meier method and compared by Log–Rank test.ResultsEight variables, including treatment, age, sex, race, marriage, tumor size, histology, and grade were selected to develop the nomogram model by univariate and multivariate cox regression. The C-index was 0.704 (95% CI, 0.694–0.714) in the training set and 0.713 (95% CI, 0.697–0.728) in the test set, which performed significantly better than 8th edition AJCC TNM stage system (0.550, 95% CI, 0.408–0.683, P &lt; 0.001). The calibration curve showed that the prediction ability of 3-years and 5-years survival rate demonstrated a high degree of agreement between the nomogram model and the actual observation. The DCA curves also proved that the nomogram-assisted decisions could improve patient outcomes.ConclusionWe established and validated a prognostic nomogram to predict 3-years and 5-years overall survival in stage IA NSCLC.