bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience with multitargeted antitumor vaccine in a child with diffuse midline glioma, H3 K27M-mutant
Authors: Кулева Светлана , Борокшинова Ксения , Балдуева Ирина , Нехаева Татьяна , Артемьева Анна , Ефремова Наталья , Емельянова Наталья , Новик Алексей , Новиков Сергей , Гиршович Михаил , Сенчуров Евгений , Гумбатова Эльвира , Хабарова Рина , Михайлова Елена , Семенова Юлия , Сахаутдинов Газиз 
Published: June 2023

Диффузная глиома высокой степени злокачественности (high-grade глиома) — наиболее часто встречающаяся высокозлокачественная первичная опухоль головного мозга с крайне агрессивным течением и неблагоприятным прогнозом.
В статье описывается клинический случай 10-летнего ребенка с диффузной срединной глиомой головного мозга с альтерацией в гене H3 K27, которому после стандартного химиолучевого лечения в качестве поддерживающей терапии создан дендритноклеточный вакцинный препарат на основе иммуногенных раковотестикулярных и GD2 антигенов [(CTA+ (cancer-testis antigen) GD2+ (ganglioside)] вакцина). Опухолевый лизат был представлен глиобластомной клеточной культурой с экспрессией GD2 96%. В качестве ростовых и дифференцировочных факторов дендритных клеток, полученных из моноцитов периферической крови, были ГМ-КСФ (гранулоцитарно-макрофагальный колониестимулирующий фактор), ИЛ4 (интерлейкин 4) и ФНОα (фактор некроза опухоли α).
Мультитаргетная иммунотерапия CTA+GD2+ аутологичной ДК-вакциной априори решает эволюционную проблему фенотипической гетерогенности и обладает большей клинической и иммунологической эффективностью в отношении high-grade глиом с их постепенным иммуноредактированием.
Development of Smart Food Value Chain Intervention Models for the Milkfish Industry in Region 1, Philippines
Authors:   College of Economics and Management, University of the Philippines Los Baños, Laguna, Philippines (CEM-UPLB), Zapata Normito R., Jr. , Sarmiento Janelle Ayne C. ,   CEM-UPLB, Cruz Mar B. ,   CEM-UPLB
Published: June 2023

Milkfish production is an important sector of the Philippine aquaculture industry. The Ilocos Region (Region 1), particularly the province of Pangasinan, is the country’s largest producer of milkfish. However, production and environmental constraints confront the milkfish industry, such as insufficient egg supply, degradation of water quality, limited processing facilities and technology, and noncompliance of small-scale processors to food safety standards. To achieve sustainability and resilience, the Department of Science and Technology-Philippine Council for Agriculture, Aquatic and Natural Resources Research and Development (DOST-PCAARRD) commissioned a value chain study to examine the current and “new normal” threats posed to Region 1’s milkfish industry. The study aims to develop intervention models to create a “smart” milkfish value chain. In a smart value chain, the industry players access quality information better, and there are technological innovations along the chain. Various milkfish industry players, such as hatchery operators, growout operators, market intermediaries, retailers, and processors, were interviewed for the study. Furthermore, consultations with various stakeholders, such as relevant government agencies and industry practitioners, determined the most suitable solutions to address the value chain’s core issues. The value chain analysis surfaced a need for an effective strategy to help farmers adopt technological solutions. In addition, the efforts of various support institutions should be harmonized and rationalized. We are proposing these interventions: (1) create a regional milkfish seedstock command center; (2) implement a science and technology community-based farm; and (3) establish a bangus processing enterprise development hub.
La adaptación del manga Hana Yori Dango al drama coreano Boys Over Flowers: similitudes y diferencias en el aspecto narrativo, enunciativo y discursivo
Authors: Lock Aspiros Fatima Susana , Aspiros Bermudez Jannet 
Published: June 2023

El presente trabajo de investigación pretende comparar la manera en que se lleva a cabo la adaptación del manga Hana Yori Dango al drama coreano Boys Over Flowers e identificar las principales similitudes y diferencias en el aspecto narrativo, enunciativo y discursivo. La investigación fue de tipo analítica, comparativa e interpretativa, con un enfoque cualitativo; y la técnica que se utiliza para aproximarse al objeto de estudio y analizar los ejes temáticos es el análisis del discurso. En conclusión, el manga va a servir como referente visual al momento de la adaptación, por lo que a lo largo del drama se puede encontrar algunas equivalencias estéticas con respecto a la versión original. A pesar de los cambios y modificaciones que se realizaron en varias escenas, la línea dramática de la historia se mantiene, siendo el tema principal el amor, el cual va a ser dramatizado y expuesto a situaciones difíciles.
Modelo de open government para optimizar la gestión municipal de un gobierno local
Authors: Quispe De los Santos Jinna Laura , Ramos Giribaldi Ana Myriam , Narvaste Bertha Silva , Llerena Rodríguez Sofía Yrene 
Published: June 2023

Este artículo tiene como objetivo presentar la implementación de un modelo de open government para optimizar la gestión municipal del gobierno local de Jayanca, tomando como referencia los fundamentos teóricos del enfoque Smart y el modelo SISTERA. Este estudio corresponde a un tipo de investigación Cuasi experimental con la aplicación de pre y pos test a una muestra de 263 ciudadanos del distrito de Jayanca. Se aplicó el instrumento: Escala para medir la gestión municipal, obteniendo como resultado que el 97.3% de los ciudadanos encuestados percibieron una baja calidad de la gestión municipal y solo un 2.7% percibieron una mediana calidad, resultando oportuna la implementación de un modelo de open government que incluya un conjunto de estrategias y acciones basadas en la transparencia y acceso a la información pública, participación y colaboración ciudadana, rendición de cuentas e integridad, innovación y tecnología, que permita optimizar la gestión municipal, luego de la implementación del modelo se aplicó nuevamente el instrumento a la muestra y se realizaron las comparaciones de los resultados del pre y pos test, para determinar su efectividad, con lo cual se determinó finalmente que el modelo de open government optimizó significativamente la gestión municipal del gobierno local de Jayanca.
The poster, from the classroom to society
Authors: Arias Villamar John , Alume Cusme Franklyn , Acosta-Torres Mónica 
Published: June 2023

The teaching processes - learning of Graphic Design, are framed in diverse visual aspects to solve problems that the current society demands. One of these aspects to deal with in this research, is the poster, and how the educator and teacher, manage a specific analysis in synergy, on the behavior that it acquires to emit a message. In the career of Graphic Design - FACSO- University of Guayaquil, two experimental workshops were held, in order to develop the compositional level of the student and in turn, to evolve the knowledge about the functionality of the poster, from the perspective of not only conceptual but also strategic problem solving graphics.
Análisis del impacto económico en la vivienda social en Portoviejo de un diseño de hormigón, enfocado en las características de los agregados gruesos y finos suministrados por canteras locales
Authors: Villafuerte Quimiz Byron Armando , Ortiz Hernández Eduardo Humberto , Panchana de Calderero Ramona 
Published: June 2023

El concreto es un material pétreo artificial usado para la construcción de diversas estructuras, desde las más complejas a las más sencillas, desde rascacielos hasta una vivienda social. Los agregados pétreos (agregado grueso y fino) representan el mayor porcentaje de los componentes que lo conforman, por ende, la elección de estos áridos a utilizar en la mezcla repercute directamente al costo de su elaboración y consecuentemente en el producto final. En la presente investigación se planteó determinar el impacto económico en la vivienda social en la ciudad de Portoviejo de un diseño de hormigón, enfocado en las características física y mecánicas de los agregados gruesos y finos suministrados por canteras locales. Se plantea realizar un diseño de la cantera “Uruzca” y otro de “Megarok” determinado así la variación económica a través de las propiedades de los agregados. El estudio se desarrolló en dos etapas: la primera corresponde al trabajo de campo y laboratorio, mientras que la segunda se enfoca en el trabajo en gabinete que contempla el procesamiento de ensayos, cálculos, dosificación de los diseños y análisis de costo. Al finalizar la investigación se obtuvo que con la cantera “Uruzca” del cerro Guayabal se tiene una reducción económica equivalente al 9.45% en comparación a la cantera “Megarok” del sector Picoazá.
Titan’s North–South Haze Asymmetry Ratio and Boundary at Visible Wavelengths over the Cassini Mission
Authors: Vashist Aadvik S. , Heslar Michael F. , Barnes Jason W. , Hennen Corbin , Lorenz Ralph D. 
Published: June 2023

Abstract
We document the evolution of the north–south asymmetry (NSA) of Titan’s haze albedo during the Cassini mission between 2004 and 2017. We analyze coadded cube images taken at 96 distinct wavelengths between 0.35 and 1.05 μm by the Cassini Visual and Infrared Mapping Spectrometer (VIMS-V) instrument from 14 Titan flybys. Over half of a Titan year, we observe a near-complete transition in the NSA boundary latitude across the geographic equator from the southern to the northern hemisphere, including a 3 yr fading of the boundary for several years after the equinox. The fading transition of the NSA matches previous observations of a reversal of the NSA in Hubble Space Telescope images of Titan before the winter solstice between 1997 and 2000. A comparison of NSA images taken at similar times but different phase angles shows the NSA boundary is detectable, albeit with less contrast, at moderately high phase angles (∼90°). Analysis of the NSA boundary in T61 and T67 VIMS images further supports a small tilt between the superrotating atmosphere and the solid body of Titan, as suggested in a previous analysis of 0.890 μm images from the Cassini Imaging Science Subsystem.
Une nationalité d’appoint. Transmissions et usages stratégiques de la double nationalité dans les espaces frontaliers lillois et genevois
Authors: Clément Garance 
Published: June 2023

Dans les agglomérations frontalières lilloise et genevoise, l’obtention de la nationalité du pays voisin est un phénomène courant qui se reproduit de génération en génération sans attirer d’attention politique ou scientifique particulière. Comment expliquer ces processus d’acquisition et de transmission d’une double nationalité qui n’offre que de faibles avantages comparatifs au sein de l’espace international ? À partir de quels arbitrages conjugaux et parentaux la double nationalité est-elle obtenue et dans quelle mesure fait-elle l’objet d’usages stratégiques au sein des populations frontalières ? En partant de situations où les processus d’acquisition se font quasiment « à nationalité égale », il s'agit d’étudier les conditions de transmission et les formes d’appropriation « subsidiaire » de la double nationalité, en les rapportant aux positions de classe, de « race » et à la génération des individus. Au carrefour de la sociologie urbaine et de la sociologie des migrations, l’article montre que la binationalité ne favorise pas seulement l’accumulation d’un capital international mais constitue également une ressource localisée, mobilisée en appoint d’autres ressources pour soutenir des stratégies résidentielles, scolaires ou fiscales.
Des migrants de luxe ? Une exploration des motivations pratiques et symboliques des bénéficiaires chinois du programme de citoyenneté par investissement canadien
Authors: May Paul 
Published: June 2023

Quelles étaient les motivations des personnes qui se sont tournées vers le programme canadien de citoyenneté par investissement ? Pour répondre à cette question, nous nous appuyons sur une série de dix-neuf entretiens semi-directifs effectués auprès de personnes d’origine chinoise ayant obtenu la nationalité canadienne par le biais de ce programme. Basée sur le concept de nationalité comme système de stratification sociale à l’échelle mondiale, cette recherche montre que l’éducation des enfants, l’accès à un logement spacieux et à un environnement sanitaire de qualité arrivent en tête des raisons avancées. La mobilité accrue, très discutée dans la littérature académique, n’est recherchée que dans la mesure où elle donne accès à ces biens. La volonté d’acquérir un statut privilégié au sein du système capitaliste mondial constitue également une source de motivation, le passeport canadien représentant un objet de distinction sociale et le signe d’appartenance aux nations les plus riches.
Déconstruire la cartographie des relations sino-africaines : le cas des ports
Authors: Aurégan Xavier 
Published: June 2023

Cet article propose une vision critique des productions – cartographiques – universitaires portant sur les rôles chinois dans les ports africains. Pour ce faire, une contre-représentation cartographique de ces présences chinoises est générée afin de prendre en compte tout d’abord les modalités d’intervention chinoises, de déconstruire ensuite la cartographie afférente et, enfin, d’inverser les représentations et la cartographie afro-chinoise portuaire. Les résultats de l’enquête font état d’une présence chinoise multimodale qui peut être qualifiée de parcellaire, avec 55 ports et 12 ports secs africains financés, construits et/ou subsidiairement gérés par un acteur chinois, mais également 149 qui ne le sont pas.
Anopheles sampling collections in the health districts of Korhogo (Côte d’Ivoire) and Diébougou (Burkina Faso) between 2016 and 2018
Authors: Taconet Paul , Zogo Barnabas , Soma Dieudonné Diloma , Ahoua Alou Ludovic P. , Mouline Karine , Dabiré Roch Kounbobr , Amanan Koffi Alphonsine , Pennetier Cédric , Moiroux Nicolas 
Published: June 2023

Characterizing the entomological profile of malaria transmission at fine spatiotemporal scales is essential for developing and implementing effective vector control strategies. Here, we present a fine-grained dataset of Anopheles mosquitoes (Diptera: Culicidae) collected in 55 villages of the rural districts of Korhogo (Northern Côte d’Ivoire) and Diébougou (South-West Burkina Faso) between 2016 and 2018. In the framework of a randomized controlled trial, Anopheles mosquitoes were periodically collected by Human Landing Catches experts inside and outside households, and analyzed individually to identify the genus and, for a subsample, species, insecticide resistance genetic mutations, Plasmodium falciparum infection, and parity status. More than 3,000 collection sessions were carried out, achieving about 45,000 h of sampling efforts. Over 60,000 Anopheles were collected (mainly A. gambiae s.s., A. coluzzii, and A. funestus). The dataset is published as a Darwin Core archive in the Global Biodiversity Information Facility, comprising four files: events, occurrences, mosquito characterizations, and environmental data.
The image of Geser in the works of artists of the 20th and 21st centuries: to pose the problem
Authors: Белокурова С.М. 
Published: June 2023

Статья посвящена исследованию различных аспектов одного из самых популярных образов в кочевой культуре Центральной Азии — Гэсэр-хану, или Абай Гэсэру, который является символом отваги, доблести, защиты слабых. Актуализация образа рассматривается на примере творчества Н.К. Рериха, а также современных художников, академиков РАХ — Н.И. Рыбакова и Ч.Б. Шонхорова. Автор анализирует произведения, посвященные Гэсэриаде, и приходит к выводу, что универсальный характер Гэсэра как героя эпоса, воспринятого всеми кочевыми народами Центральной Азии, предполагает многочисленные грани образа, которые могут заинтересовать художников. А именно: связь героя со стихией земли, символическая слабость героя по сравнению с врагом, идеальный образ богатыря-защитника. Именно эти характеристики делают образ актуальным, ярким и вдохновляющим и для художника, и для зрителя.
The article is devoted to the study of various aspects of one of the most popular images in the nomadic culture of Central Asia — Geser Khan, or Abai Geser, who is a symbol of courage, valour, protection of the weak. The actualization of the image is considered on the example of the pictures painted by N.K. Roerich, as well as contemporary artists, academicians of the Russian Academy of Arts — N.I. Rybakov and Ch.B. Shоnkhorov. The author analyses the works of artists dedicated to the Geseriada and comes to the conclusion that the universal character of Geser, as the hero of the epic, perceived by all the nomadic peoples of Central Asia, suggests numerous facets of the image that may interest artists. Namely, the connection of the hero with the earth, the symbolic weakness of the hero in comparison with the enemies, the ideal image of the hero-defender. It is these characteristics that make the image relevant, bright and inspiring for both the artist and the viewer.
El estudio del pasado como objeto y como método
Authors: Sadarangani Javier 
Published: June 2023

Reseña de VINÍCIUS DE MORAIS, Marcus. Bolívar entre a Cruz e a Espada. Independencias e usos do passado colonial (1818-1822).
Review of VINÍCIUS DE MORAIS, Marcus. Bolívar entre a Cruz e a Espada. Independencias e usos do passado colonial (1818-1822).
MUSEOS EMANCIPADORES
Authors: Cortés Aliaga Gloria 
Published: June 2023

El presente texto intenta proponer prácticas museológicas que permitan crear nuevas etimologías, epistemologías y experiencias situadas al interior del museo a partir de la incorporación del sujeto “mujer” a la propia historia de la institución, entendiendo por “mujer(es)” a un cuerpo político más allá de su concepción cultural-biológica. De este modo, instalar la historia de los cuerpos feminizados en el museo, afectados todos ellos por cuestiones de género, racialización, clase, geografía, territorios, entre otros tantos agentes generadores de la desigualdad, obliga a la institución a reflexionar sobre sí misma y agitar las narrativas y las formas de hacer para provocar modos alternativos de agenciamiento comunitario y colectivo.
A partir del análisis de un conjunto de acciones autoconvocadas por sus trabajadoras y la invitación a diferentes artistas a accionar el museo, realizadas desde el año 2017 al 2023, se abordará el impacto que ejercen las prácticas curatoriales en el contexto institucional, a partir de la subversión del canon al interior de las colecciones, de encontrar las fisuras que permitan la incorporación de nuevos sujetos políticos y de la activación feminista.
The Impact of Work-Life Balance on Employee Work Quality Improvement in Nigeria
Authors: Abiodun Solihu Abdulakeem , Iyobhebhe Itohan , Sam Aitaa Sam Kilimvi 
Published: June 2023

Purpose: The challenge of achieving a healthy work-life balance (WLB) is a persistent concern in many organizations, with only a minority of businesses taking proactive measures to address it. Consequently, it is imperative to assist workers in establishing a healthy work-life balance. The primary aim of this study is to analyze the impact of work-life balance on enhancing employees' work quality. The research attempted to provide answers to the following research questions: i) Does flexible work arrangements impact employee job quality? (ii) Do leave policies to contribute to enhancing employee job quality? (iii) Do opportunities for career advancement impact employee work quality?
Methodology: The study employed epistemological research design, which concerns the logical inquiry and acquisition of knowledge reflecting on the researcher's perspective on the topic. The research used an inductive and interpretive methodology. Secondary data was obtained from Google Scholar, Research gate, and other open Access sources, to locate relevant and current publications for analysis and interpretation. Publications from 2012 and 2022 on WLB, Work Quality, Leave Policies, Career Progression, FWAs, and the impact of WLB on improving work quality considered as search variables.
Findings: The findings showed a significant impact of Flexible Work Arrangements (FWAs) on the quality of employee work. Additionally, a positive correlation was observed between employee work quality and leave programs. Finally, the study's findings indicate that career development opportunities impact the quality of productive work.
Recommendations: Consequently, the research suggests that adopting Flexible Work Arrangements (FWAs) by business managers could lead to an increase in employee contentment, a reduction in stress levels, and ultimately, an enhancement in work performance. The study also recommended that organizations provide employees with adequate and unobstructed access to leave and opportunities for career progression, as this can lead to increased job satisfaction.
Pola Pengobatan Dan Analisis Potensi Interaksi Obat Pada Pasien Anak Demam Berdarah Dengue (Dbd) Di Rumah Sakit Kalimantan Timur
Authors: Rahma Helda , Alim Muthia Dewi Marthilia 
Published: June 2023

Background: Dengue hemorrhagic fever is caused by transmission of the dengue virus by the Aedes aegypti mosquito. Dengue hemorrhagic fever is common in tropical countries such as Indonesia, where new cases are found every year. According to WHO that dengue fever is the leading cause of hospitalization for children. Dengue hemorrhagic disease is more susceptible to infection in children because the child's immune system is still very weak, so the virus is easy to multiply quickly in the body. Knowing the pattern of treatment and analysis of potential drug interactions in pediatric patients with dengue hemorrhagic fever at the East Kalimantan Hospital.
Methods: The research is non-experimental observational with a descriptive research design. The approach method used is the cross sectional method. Identification of data collection is carried out retrospectively, by taking sources from medical records for the years 2020-2021.
Results: Of the 47 patient samples, the most cases were male patients as many as 27 patients (57%) with the age of 11 years as many as 11 patients (23%) with a length of stay of less than 7 days as many as 45 patients (96%). Based on the pattern of treatment, the most widely used therapy was the rehydration group (RL) 28 patients (60%). In the case of drug interactions occurred as many as 2 cases (3%).
Conclusion: In this study show that there are cases of drug interactions.