bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biochar produced from pressed palm fibre to removal β‐carotene from crude palm oil
Authors: Segala Bibiane Nardes , Steffens Bruna Clarissa , Ballus Cristiano Augusto , Bertuol Daniel Assumpção , Tanabe Eduardo Hiromitsu 
Published: January 2025

AbstractAdsorbents produced from the reuse of pressed palm fibres, a residue derived from the palm oil extraction process, are an alternative to commercial adsorbents for the removal of β‐carotene from crude palm oil. Two adsorbents produced by the pyrolysis of pressed palm fibres were analyzed, where one was chemically activated with phosphoric acid and the other was not activated. Under the conditions studied, biochar activated with phosphoric acid presented an adsorption capacity of 2.99 mg g−1 and 86% β‐carotene removal. The results of kinetic tests indicated that the pseudo‐second order (PSO) model revealed the best fit to the experimental data. The isothermal curves suggested the Brunauer–Emmett–Teller (BET) model adjusted better for the isotherms of 30, 40, and 50°C, while the Freundlich model was the one that best described the isotherm of 60°C. Thermodynamic parameters indicated that the adsorption process was spontaneous, favourable, and endothermic. Furthermore, the activated biochar showed a significant reduction in phosphorus content, indicating an alternative to commercial adsorbents (bleaching earths) traditionally used in the crude palm oil refining process, while also aligning with the principles of the circular economy. Analyses were carried out to characterize the adsorbent material and quantify the oil quality parameters.
Sustainable steel production: a question of the reducing agent
Authors: Zell Lukas , Nick Jonas , Quarthal Dominik , Oetken Marco , Friedrich Jens 
Published: January 2025

AbstractDie Stahlindustrie zählt zu den größten Verursachern von Kohlenstoffdioxid‐Emissionen. Um die Emissionen zu reduzieren, gibt es Bestrebungen, Eisen nicht durch Kohle, sondern durch Methan oder Wasserstoff zu reduzieren. Diese beiden Reduktionsmittel haben im Vergleich zu Kohlenstoff den Vorteil, weniger bis gar keine direkten Kohlenstoffdioxidemissionen zu generieren. Im Kontext eines zukunftsorientierten Chemieunterrichts werden in diesem Artikel zwei Experimente zur Reduktion von Eisen(III)‐oxid mit Wasserstoff und Methan vorgestellt.
Host‐Matrix Interactions and Molecular Functionalization: Shaping the Delayed Emission Properties of Indenophenanthridine Derivatives
Authors: Govindharaj Prasannamani , Kannan Jamuna , Shanmugam Sivakumar , Data Przemysław 
Published: January 2025

AbstractThe advancement of organic room temperature phosphorescence (RTP) materials has attracted considerable interest owing to their extensive applications. Their distinct advantages, including a metal‐free composition, low toxicity, and facile synthesis under ambient conditions, make them highly desirable. This study examines the delayed fluorescence (DF) and RTP of metal‐free, amorphous indenophenanthridine (IND)‐based derivatives (1–10) and provides insights into molecular functionalisation and host matrix effects on delayed emission (RTP and DF). IND derivatives have been used in bioimaging and organic analyte detections; however, their delayed emission mechanism photophysical processes are poorly understood. This work examines the derivatives’ physicochemical properties and time‐resolved photophysics to determine how molecular structure, host interaction, and delayed emission properties relate. The described IND compounds show RTP and/or TTA (triplet‐triplet annihilation) delayed fluorescence depending on the host environment. This research lays the groundwork for designing and developing new materials with increased RTP efficiency for future applications by detailing the detailed RTP processes and the crucial function of the host matrix.
Acceleration of Large‐Scale Power System Analysis Including Phase‐Domain Rotating Machine Models Using Partial Refactorization in Electromagnetic Transient Analysis
Authors: Yonezawa Rikido , Kawasaki Shoji 
Published: January 2025

ABSTRACTOne of the models for rotating machines, such as synchronous machines and induction machines, is the phase‐domain model, which is characterized by formulating the circuit equations of the rotating machine in the phase domain and solving them simultaneously with the external system to which the rotating machine is connected. Although this model has excellent numerical stability and calculation accuracy, it requires refactorization of the subcircuit that includes the rotating machine at each calculation time step, which degrades the calculation speed. This paper describes the results of an attempt to improve the calculation speed when using the phase‐domain model by using partial refactorization, which makes the refactorization process more efficient.
Unlocking the power of empagliflozin: Rescuing inflammation in hyperglycaemia‐ exposed human cardiomyocytes through comprehensive multi‐level analysis
Authors: Benedetti Rosaria , Chianese Ugo , Papulino Chiara , Scisciola Lucia , Cortese Mirko , Formisano Pietro , Del Gaudio Nunzio , Cabaro Serena , D'Esposito Vittoria , Pesapane Ada , Conte Mariarosaria , Signoriello Giuseppe , Barbieri Michelangela , Altucci Lucia , Paolisso Giuseppe 
Published: January 2025

AimsHyperglycaemic conditions increase cardiac stress, a common phenomenon associated with inflammation, aging, and metabolic imbalance. Sodium–glucose cotransporter 2 inhibitors, a class of anti‐diabetic drugs, showed to improve cardiovascular functions although their mechanism of action has not yet been fully established. This study investigated the effects of empagliflozin on cardiomyocytes following high glucose exposure, specifically focusing on inflammatory and metabolic responses.Methods and resultsA three‐part strategy was formulated: (i) a meta‐analysis of selected randomized clinical trials was carried out to assess the anti‐inflammatory effects of empagliflozin in diabetic patients; (ii) the impact of empagliflozin on human cardiomyocyte AC16 cells exposed to normal (5 mM) and high (33 mM) glucose concentrations for 2 and 7 days was explored by evaluating gene expression and protein levels of pivotal markers associated with cardiac inflammation, stress, endoplasmic reticulum damage, and calcium modulation; (iii) in silico data from bioinformatic analyses were exploited to construct an interaction map delineating the potential mechanism of action of empagliflozin on cardiac tissue. Empagliflozin reversed high‐glucose mediated alterations at the transcriptional level, decreasing inflammatory, metabolic, and aging signatures. Specifically, in vitro experiments on human cardiomyocytes, meta‐analyses of clinical data on inflammatory biomarkers from diabetic peripheral blood samples, and sequencing of pathological human heart tissues, all support that empagliflozin exerts anti‐inflammatory effects both systemically and directly in cardiac tissue, on cardiomyocytes.ConclusionOur study provides insights based on robust mechanistic data for optimizing heart failure management and highlights the intricate interplay between diabetes, inflammation, aging, and cardiovascular health.
Diagnostic models to differentiate Takotsubo syndrome from acute coronary syndrome: A systematic review and meta‐analysis
Authors: Diaz‐Arocutipa Carlos , Hernandez Adrian V. , Benites‐Moya Cesar Joel , Gamarra‐Valverde Norma Nicole , Yrivarren‐Cespedes Rafael , Torres‐Valencia Javier , Vicent Lourdes 
Published: January 2025

AbstractAimsDifferentiation between patients with Takotsubo syndrome and acute coronary syndrome (ACS) remains a challenge. We performed a systematic review to identify and evaluate diagnostic predictive models to distinguish both conditions.Methods and resultsWe performed an electronic search in PubMed, EMBASE, and Scopus until January 2024. Observational studies that developed and/or validated multivariable diagnostic models to differentiate Takotsubo syndrome from ACS were included. The risk of bias was assessed using the Prediction model Risk Of Bias ASsessment Tool (PROBAST). We conducted a narrative synthesis of the performance measures of the diagnostic models evaluated in each study. In addition, a random‐effects meta‐analysis of the c‐statistic with its 95% confidence interval (CI) of the InterTAK model was performed. Of 1015 articles, a total of 11 studies (n = 4552) were included. We identified eight new diagnostic models and eight were external validation of existing models. The most frequent model was InterTAK (n = 4). The reported c‐statistic ranged from 0.77 to 0.97 across all models. Calibration plots were reported only for two models. The summary c‐statistic was 0.89 (95% confidence interval 0.73–0.96) for the InterTAK model. The risk of bias was high for all models and the applicability was of low (50%) or unclear (50%) concern.ConclusionOur review identified multiple diagnostic models to diagnose Takotsubo syndrome. Although most models showed acceptable‐to‐good discriminative performance, calibration measures were almost unreported and the risk of bias was a concern in most studies.
Rediscovery of Nepeta koeieana (Lamiaceae): A Presumed Extinct Nepeta From Zagros Mountains, Iran
Authors: Zeraatkar Amin , Shirmardi Hamzehali 
Published: January 2025

ABSTRACTNepeta koeieana, an extremely rare and narrowly endemic species, has been rediscovered after 87 years in Kuhrang County, Chaharmahal, and Bakhtiari province. Species identification was conducted through an extensive review of taxonomic literature and comparison with similar species using herbarium specimens under a stereomicroscope. Colored photographs of the habitat and live plants, a table of comparisons, detailed morphological illustrations of closely allied species, and a geographical distribution map are provided. A revised morphological description based on fresh specimens, along with a discussion of the species' taxonomic position, is also included. Additionally, the typification of the species name is addressed. Field surveys evaluated population size, habitat, ecological interactions, and conservation status, and maps were created using Google Earth. The species is assessed as critically endangered (CR) based on its very small and restricted population size.
Analytical Solution and Energy Behavior to a Forced Shock Wave Problem Under Dusty Gas Regime
Authors: Gautam Ram Asrey , Nath Triloki 
Published: January 2025

ABSTRACTIn the presented research work, we have solved a new kind of problem of forced shock waves in a compressible inviscid perfect gas having dirty (dust) particles of small size in a one‐dimensional unsteady adiabatic flow. The approach that we have used is referred to as the generalized geometry approach. Here, we investigated how the density of the zone, which is undisturbed, changes as a function of the position from the point of the source of explosion. In addition, we have obtained analytically a novel solution to the problem in the form of a new rule of power of time and distance. Further, we have investigated the energy behavior of forced shock waves and interaction within the environment containing dust particles. Also, the behavior of the entire energy of a forced shock wave is expounded at different Mach numbers, respectively, for planar geometry, cylindrically symmetric geometry, and spherically symmetric geometry under a dusty gas medium. Furthermore, the findings show that dust particles in a gas produce a more sophisticated representation rather than the standard gas dynamics.
From Stigma to Strength? The Interrelations Between Sexual Identity Stigma, Well‐Being, and Accepting Communities on Instagram Amongst Sexual Minority Youth
Authors: Noon Edward John , Maes Chelly , Karsay Kathrin , Yang Chia‐chen , Pesout Ondra , Stefańczyk Michał Mikołaj 
Published: January 2025

ABSTRACTIntroductionInitial evidence suggests that engaging with accepting communities on social media such as Instagram may inform sexual minority youths' sense of stigma and well‐being. However, as existing research has predominately drawn upon cross‐sectional or qualitative designs, it is currently unclear whether the positive experiences identified in previous research accumulate, endure, or evolve over time. We also know relatively little about whether engagement with accepting online communities is primarily a compensatory or enhancing behavior. Thus, drawing upon minority stress theory and broaden‐and‐build theory, this study explores the longitudinal reciprocal relationships between perceived stigma, well‐being, and engagement with accepting Instagram communities.MethodThree‐wave panel data were collected from 460 sexual minority youth in the United States and Poland (M age = 18.58, SD = 1.64), and data were analyzed using a random intercept cross‐lagged panel model.ResultsAt the between‐person level, engagement with accepting Instagram communities was positively associated with perceived stigma and negatively associated with well‐being. No significant within‐person associations emerged between perceived stigma and engagement with accepting Instagram networks. However, a positive reciprocal relationship was found between well‐being and engagement with accepting Instagram communities. Cultural context had no moderating effect on the hypothesized model.ConclusionsResults suggest that whilst the interrelations between perceived stigma and engaging with accepting online networks may be short‐lived, engaging with supportive Instagram communities may contribute to an upward spiral of positive emotions. Findings therefore extend the existing literature regarding the potential benefits of social media use amongst sexual minority youth.
Effectiveness of a Novel PLA2R1 Knock‐In Rat Model in Repairing Renal Function Damage
Authors: Huang Bo , Sui Wen‐dong , Zhang Zi‐tong , Zhao Lu , Li Yin‐yin , Yang Dai‐he , Zhou Yun 
Published: January 2025

ABSTRACTPhospholipase A2 receptor 1 (PLA2R1) exists in many animals and plays an important role in membranous nephropathy. In this study, we aimed to evaluate a PLA2R1 knock‐in rat model with repaired kidney function to study the molecular mechanisms of membranous nephropathy. We constructed the PLA2R1 knockout [PLA2R1(−)] model and PLA2R1 knock in [PLA2R1(+)] model in rats. Consistent complement C3 and IgA expression was confirmed through colocalization studies. Urinary biochemical indicators were performed using Automatic Biochemistry Analyzer. The complement C3, IgG, and Nephrin were detected by immunofluorescence assay. The expression levels of complement C3, IgA, and PLA2R1 were detected by western blot. The differential expression proteins (DEPs) between control and PLA2R1(+) models were detected by liquid chromatography with tandem mass spectrometry. The PLA2R1(−) model showed proteinuria, complement C3 aggregation, and IgA and IgG deposition in the glomerulus. Comparing with the PLA2R1(−) model, the PLA2R1(+) model, the deposition of complement C3 and IgA in the glomerulus did not completely disappear, and IgG expression weakened. Moreover, the absolute value of urinary protein was much lower in the PLA2R1(+) model than in the PLA2R1(−) model, and some of the humanized PLA2R1 gene fragments repaired some of the kidney functions. Humanized PLA2R1‐insertion in rats can repair part of the renal function and reduce proteinuria, which will help in studying the molecular mechanisms of membranous nephropathy, as well as the entire membranous nephropathy‐related system and complement activation signaling pathway.
Systematic Molecular Influenza A/B Screening Upon Hospital Admission in Belgium, January–April 2022: Positivity Ratios and Viral Loads According to Symptomatology, Age, and Vaccination Status
Authors: Huyghe Evelyne , Abrams Steven , André Emmanuel , Anseeuw Kurt , Bernaert Eva , Bruynseels Peggy , Cuypers Lize , De Schouwer Pieter , Hilkens Petra , Keyaerts Els , Laenen Lies , Maes Justine , Magerman Koen , Van de gaer Otto , Verdonck Ann , Verstrepen Walter , Ombelet Sien , Naesens Reinout 
Published: January 2025

ABSTRACTThree hospitals implemented molecular point‐of‐care tests (POCTs) to screen patients for SARS‐CoV‐2 infection upon admission during the 2021/2022 influenza season, which in Belgium lasted from January to April 2022. The samples were simultaneously tested for influenza A/B. Influenza positivity at admission was examined in relation to patient characteristics and symptomatology. Influenza POCTs were performed on all patients requiring urgent hospitalization, regardless of the admission reason. A total of 9327 patients were included in the study, of which 411 (4.4%) tested positive for influenza A/B. Asymptomatic infection and mild illness accounted for respectively 11.2% (95% CI: 8.5%–14.6%), and 43.3% (95% CI: 38.6%–48.1%) of the cases. A total of 66% (95% CI: 60%–72%) of all patients in these symptom categories (asymptomatic and mild illness) showed a high viral load (cycle threshold [Ct] < 24). Only in 30 (7.3%, 95% CI: 5.2%–10.2%) of all cases and in two (4.4%, 95% CI: 1.2%–14.5%) of the asymptomatic cases, the symptomatology worsened during hospital stay. Coinfections with both influenza and SARS‐CoV‐2 occurred in 35 patients (8.5% of all influenza positive patients). There was no difference in symptomatology between patients with co‐infections and those with an influenza mono‐infection. Patients could not be reliably categorized into carriers with low versus high viral loads based on symptomatology, age, and vaccination status. More than half of the influenza‐positive individuals were either asymptomatic or had mild symptoms upon admission, while often carrying high viral loads. Our results show that without screening of patients at hospital admission, a considerable number of patients with a high viral load may be incorrectly classified as being not infectious.
Work Engagement in Agile Teams: Extending Multilevel JD‐R Theory
Authors: Junker Tom L. , Bakker Arnold B. , Derks Daantje , Pletzer Jan Luca 
Published: January 2025

ABSTRACTTeams often fail to mobilize their resources effectively, which can undermine team engagement. Prominent work engagement theories, including Job Demands‐Resources (JD‐R) theory, have not accounted for this conceptually. By taking a closer look at how teams can mobilize resources through their use of agile work practices (AWPs), we develop a multilevel extension of JD‐R theory. First, we propose that agile taskwork (i.e., use of sprint planning and iterative development practices) contributes to team engagement, especially in teams working on complex tasks. Second, we argue that agile teamwork (i.e., frequency of stand‐up and retrospective meetings) promotes team engagement only when team role conflict low. We test our hypotheses in a field study involving 110 teams (N = 694 employees) with multisource ratings of job demands and two different operationalizations of team engagement. Our findings demonstrate which AWPs contribute more (vs. less) strongly to team engagement. Moreover, results evidence the boosting principle of JD‐R theory at the team‐level by showing that resource mobilization through agile taskwork is most engaging in challenging contexts (i.e., high work complexity). We discuss the implications of these findings for JD‐R theory and research on collective work engagement.
hnRNPA2B1 drives colorectal cancer progression via the circCDYL/EIF4A3/PHF8 axis
Authors: Sun Yu‐Kai , Wang Jin‐Fu , Sun Xi‐Wen , Zhang Ming 
Published: January 2025

AbstractThe RNA‐binding protein hnRNPA2B1 acts as an m6A reader and plays a role in tumor development. This study investigates the potential mechanism of hnRNPA2B1 in colorectal cancer (CRC) progression. The expression profiles of hnRNPA2B1, circCDYL, and PHF8 in CRC cell lines were analyzed. Following si‐hnRNPA2B1 transfection, CRC cell proliferation, invasion, and migration were evaluated by CCK‐8 and Transwell. CDYL expression was detected after actinomycin D and RNase R treatment. RIP was conducted to assess the enrichment of hnRNPA2B1 and m6A on circCDYL. RIP and RNA pull‐down assays established the interaction between circCDYL and EIF4A3/PHF8. EIF4A3 expression was evaluated using RT‐qPCR and Western blot techniques. hnRNPA2B1 and PHF8 displayed high expression levels, whereas circCDYL showed low expression levels in colorectal cancer cells. Inhibition of hnRNPA2B1 reduced CRC cell proliferation, migration, and invasion. hnRNPA2B1 mechanistically elevated the m6A level of circCDYL while decreasing its expression, which in turn reduced the binding of circCDYL to EIF4A3 and enhanced PHF8 expression. In summary, hnRNPA2B1‐mediated m6A modification decreases circCDYL expression, which inhibits the interaction of circCDYL with EIF4A3, enhances PHF8 expression, and ultimately facilitates CRC progression.
Higher hospital volume reduces early failure rates in single‐stage revision TKR for infection: An analysis of the United Kingdom National Joint Registry and National Administrative Databases
Authors: Matthews Alexander H. , Gray William K. , Evans Jonathan P. , Knight Ruth , Evans Jonathan T. , Lamb Sarah E. , Briggs Tim , Porteous Andrew , Sabah Shiraz A. , Alvand Abtin , Price Andrew , Toms Andrew D. 
Published: January 2025

AbstractPurposeRevision knee replacement (RevKR) for infection is rare but increasing. It is hypothesised that higher hospital volume reduces adverse outcomes. The aim was to estimate the association of surgical unit volume with outcomes following first, single‐stage RevKR for infection.MethodsThis population‐based cohort study merged data from the United Kingdom National Joint Registry, Hospital Episode Statistics, National Patient Reported Outcome Measures and the Civil Registrations of Death. Patients undergoing procedures between 1 January 2009 and 30 June 2019 were included. Early outcomes were chosen to reflect the quality of the surgical provision and included re‐revision at 2 years, mortality, serious medical complications, length of stay and patient‐reported outcome measures (PROMs). Adjusted fixed effect multivariable regression models were used to examine the association between surgical unit mean annual caseload and the risk of adverse outcomes.ResultsA total of 1477 patients underwent first‐time single‐stage RevKRs for infection across 267 surgical units and 716 surgeons. Following adjustment for age, gender, American Society of Anaesthesiologists grade, surgeon volume, year of surgery and operation funder and modelling surgical unit volume with restricted cubic spline, a greater mean annual volume was associated with a lower risk of re‐revision at 2 years. The odds of re‐revision in hospitals performing fewer than or equal to 12 cases per year was 2.53 (95% confidence interval = 1.50–4.31) times more likely than hospitals performing three to four cases per month. Annual variation in surgical unit volume was not associated with mortality and serious medical complications within 90 days. Only 99 out of 1477 (7%) of patients had linked PROMs which precluded subsequent analysis.ConclusionOverall, higher volume surgical units had lower rates of early re‐revision following the first RevKR for infection. We were unable to provide recommended specific volume thresholds for units; however, the probability of re‐revision appears to be lowest in the highest volume units.Level of EvidenceLevel III, retrospective cohort study of prospectively collected data.