bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilization of Treat-to-Target Monitoring Colonoscopy After Treatment Initiation in the US-Based Study of a Prospective Adult Research Cohort With Inflammatory Bowel Disease
Authors: Yang Jeff Y. , Lund Jennifer L. , Funk Michele Jonsson , Hudgens Michael G. , Lewis James D. , Kappelman Michael D. 
Published: April 2023

INTRODUCTION:
Endoscopic healing has been associated with improved long-term clinical outcomes in inflammatory bowel disease (IBD) and is a recommended target for treatment. Evidence is limited regarding real-world uptake and patterns of treat-to-target monitoring to assess endoscopic healing after treatment initiation. We aimed to estimate the proportion of patients in the Study of a Prospective Adult Research Cohort with IBD (SPARC IBD) who received colonoscopy in the 3–15 months after starting a new IBD treatment.

METHODS:
We identified SPARC IBD patients who initiated a new biologic (infliximab, adalimumab, certolizumab pegol, golimumab, vedolizumab, and ustekinumab) or tofacitinib. We estimated the proportion of patients who received colonoscopies in the 3–15 months after IBD treatment initiation and described use by patient subgroups.

RESULTS:
Among 1,708 eligible initiations from 2017 to 2022, the most common medications were ustekinumab (32%), infliximab (22%), vedolizumab (20%), and adalimumab (16%). The median patient age was 38 years, with 66% Crohn's disease; 55% were female, and 12% were non-White. In the 3–15 months after medication initiation, 49.3% (95% confidence interval 46.2%–52.5%) of initiations were followed by a colonoscopy. Colonoscopy use was similar between ulcerative colitis and Crohn's disease, but was higher among male patients, those older than 40 years, and those who received colonoscopy within 3 months of initiation. Colonoscopy use varied between study sites, from 26.6% (15.0%–38.3%) to 63.2% (54.5%–72.0%).

DISCUSSION:
Approximately half of SPARC IBD patients received colonoscopy in the 3–15 months after initiation to a new IBD treatment, suggesting a low uptake of treat-to-target colonoscopy for the assessment of mucosal healing in real-world clinical practice. The variation in colonoscopy use between study sites suggests a lack of consensus and a need for more robust evidence around whether or not the practice of routine monitoring colonoscopy is associated with improved patient outcomes.
The effect of the growth ring orientation on spring-back and set-recovery in surface-densified wood
Authors: Scharf Alexander , Lemoine Antoine , Neyses Benedikt , Sandberg Dick 
Published: April 2023

Abstract
Wood under thermo-mechanical densification behaves differently depending on the cross-sectional growth ring orientation (GRO) relative to the direction of compression. This influences the degree of cell damage, but also the shape-memory effects occurring when the compression load is released (spring-back) and when the timber is re-moistened (set-recovery). To study how the GRO influences the shape-memory effects, Scots pine specimens were separated into three distinct groups of GRO (Flat, Inclined, Hybrid) and then thermo-mechanically surface-densified. Spring-back and set-recovery were determined by thickness measurements and by digital image correlation. A GRO parallel to the densified surface, resulted in a low spring-back and a high set-recovery which were uniform over the width of the specimen. Specimens with a GRO between 15 and 45° to the densified surface showed high spring-back and low set-recovery, indicating cell-wall damage. Spring-back mainly occurred in the non-plasticised region immediately below the heated surface region and elasto-plastic rolling-shear deformation along individual growth rings occurred. The GRO of softwood subjected to thermo-mechanical densification determines if an applied load results in rolling shear-deformation or radial compression. This in turn determines where in the cross-section and when in the process the cells deform and if this deformation occurs below or above the glass-transition temperature.
Preparation of CaO–SiO2–Al2O3 inorganic fibers from melting-separated red mud
Authors: Du Peipei , Zhang Yuzhu , Long Yue , Xing Lei 
Published: April 2023

Abstract
To investigate the feasibility of preparing CaO–SiO2–Al2O3 inorganic fibers with melting-separated red mud, the properties of the melting-separated red mud were analyzed by X-ray fluorescence, X-ray diffraction, and differential thermal-thermogravimetric analyses. The composition of the melting-separated red mud satisfied the requirements for the composition of inorganic fibers. During the melting of the melting-separated red mud, tetrahedral skeleton fracture reactions occurred at 1,234°C, anionic group reverse binding occurred at 1,250°C, and there was no other obvious reaction peak during the whole melting process, which lasted for 51 min. The minimum suitable fiber forming temperature of the melting-separated red mud melt was 1,433°C, which was 83°C greater than its crystallization temperature, 1,350°C. Within this temperature range, the activation energy of particle movement in the melt was 1008.65 kJ·mol−1, and the melt exhibited good fluidity. Considering the temperature distribution corresponding to the melting properties of the melting-separated red mud, CaO–SiO2–Al2O3 inorganic fibers could be prepared when the melting-separated red mud was subjected to component reconstruction by increasing the silicon content, reducing the aluminum content, and adding a moderate amount of calcium. Quartz sand and light burnt dolomite were used as modifying agents and inorganic fibers were prepared under laboratory conditions. The fibers prepared from the modified melting-separated red mud by adding different amounts of melting-separated red mud had smooth surfaces and were arranged in a crossed manner at the macroscopic level. Their color was grayish-white, and small quantities of slag balls were doped inside the fibers. With an increase in the amount of melting-separated red mud from 50 to 100%, the average fiber diameter increased from 5.5 to 8.0 μm, and their slag ball content increased from 2.9 to 6.0%. Overall, under laboratory conditions, when the amount of melting-separated red mud added was 50%, dolomite was 22.5% and quartz sand was 27.5%, the performance of the fiber was the best.
Time series data for process monitoring in injection molding: a quantitative study of the benefits of a high sampling rate
Authors: Bogedale Lucas , Schrodt Alexander , Heim Hans-Peter 
Published: April 2023

Abstract
Process monitoring systems are playing an increasingly important role in reducing production capacity losses in injection molding. Process monitoring and optimization systems are mostly based on processing data of injection molding machine control systems. These data consist of scalar data and time series. This paper introduces a novel approach to modelling injection molding processes using only time series data and evaluates the quantitative influences of varying sampling times on calculation of integral values and model quality. On the basis of the first experiment, it is shown that the sampling rates of these time series have a large influence on information which can be derived from this data (e.g. injection work). These findings provide an assessment of whether the effort is justified for the respective requirements on the accuracy of the injection work and other parameters derived from the time series. In the second experiment, a model is presented which uses only the injection flow and injection pressure profile as input and achieves high coefficients of determination for the prediction of the part weight, despite the absence of mold sensor data and scalar data. It is shown that higher sampling rates of time series results in higher prediction quality of these models. This improves the understanding of the data needed for high quality machine learning models of injection molding processes and enable users to estimate a lower bound for the sample rates of time series for their use cases.
„Weglassen, wovor man sich eher hüten sollte“: Zu inhaltlichen Veränderungen in der offiziellen Übersetzung einer safavidischen Weltchronik ins Türkische im Istanbul der „Tulpenzeit“
Authors: Bockholt Philip 
Published: April 2023

Abstract
In the 1720s, the Ottoman grand vizier Dāmād İbrāhīm Pasha ordered a translation of the Persian world history Ḥabīb al-Siyar into Turkish. The chronicle deals with the history of the Islamic world until the 1520s and was penned 200 years earlier by the historian Khvāndamīr in Iran for the ruling dynasty of the Safavids. As its author composed it for the archenemies of the Ottomans and gave it a Shiʿi outlook, the committee of eight translators assigned by the grand vizier faced the challenge of translating explicitly anti-Ottoman and pro-Shiʿi sections within the text. By contextualizing the Turkish version of the Ḥabīb al-Siyar, the article sheds light on the question of how texts were translated during the so-called Tulip Age. Specifically, it analyzes the approach taken by the translators concerning historical events of utmost importance to the Ottomans, such as Sultan Bāyezīd I’s defeat by Timur at Ankara in 804/1402 and Sultan Selīm’s victory over Shah Ismāʿīl at Chāldirān in 920/1514. Another point of interest is the depiction of the Sayyid lineage of the Safavids as given in both texts, which was a controversial issue between the two dynasties for centuries.
Muḥammad und Cædmon und die Siebenschläferlegende. Zur Verbindung zwischen Palästina und Canterbury im 7. Jahrhundert
Authors: Eich Thomas 
Published: April 2023

Abstract
There are strong parallels between the popular description of Muḥammad’s first revelation in the Sīra of Ibn Isḥāq and a depiction of a seventh-century Northumbrian monk Cædmon in the Historia ecclesiastica gentis Anglorum by Bede Venerabilis. There has been some debate about whether these parallels are more or less coincidental, but very good arguments for a relation between the two texts have been put forward. This article adds to this line of research by providing a concrete model of how a Middle Eastern Vorlage might have traveled to Bede Venerabilis. It is argued that the archbishop of Canterbury, Theodore of Tarsus (d. 690), played a key role in this transfer. His biography puts into focus the transposition of Greek-Palestinian and -Egyptian monk congregations including relics and texts to Italy and especially Rome during the seventh century. The relevance of the surviving texts from the school of Canterbury for the study of seventh-century Middle Eastern history is then further illustrated with a version of the so-called legend of the Seven Sleepers of Ephesos recorded in Theodore’s biblical exegesis. Theodore’s specific version of that legend overlaps significantly with the version contained in the Qurʾān in Sura 18 (al-Kahf, “The cave”). It has always been clear that Sūrat al-Kahf refers to the Christian Seven Sleepers legend. However, since all other hitherto known versions of the story differed significantly from the Qurʾān version, the connection between the versions was usually imagined within a model of “oral transmission.” The version recorded from Theodore’s seventh century teaching sessions now allow us to draw a more nuanced picture in which this specific version of the legend can be situated in seventh-century Palestine. Possibly it was linked to the veneration of Lot in that region, drawing a parallel between Lot’s wife, who had supposedly been transformed into a pillar of salt, but was apparently thought to not have died, and the unnaturally long sleep of the Seven Sleepers over centuries.
The Crisis of Religious Identity in Sixteenth Century Central Asia: The Centrality of ʿAlidism in the

Maẓhar al-ʿAjāʾib
Authors: Shanazarova Aziza 
Published: April 2023

Abstract
The present study explores the centrality of ʿAlidism in the religious profile of a Sufi community active in the early sixteenth century in Mawarannahr, which was at the center of the ongoing major religio-political transformations in the aftermath of the decline of the Timurid dynasty. This community was led by a female Sufi master celebrated as Aghā-yi Buzurg (the Great Lady). The misfortunes faced by Aghā-yi Buzurg and her followers during this critical transitional period was related to her group’s upholding the Timurid-era tradition of ʿAlid devotion under the early Shibanid rule. The public proclamation of pro-ʿAlid sentiments in post-Timurid Central Asia became dangerous in the early sixteenth century when the veneration of ʿAlī and his descendants started being associated with sympathies toward the Shiʿi Safavids. It is remarkable that Aghā-yi Buzurg’s public career as a leader of the Sufi community consisting of male and female disciples was not the main factor provoking the attacks against her community, but instead, it was their admiration of ʿAlī and his descendants.
On-chip multivariant COVID 19 photonic sensor based on silicon nitride double-microring resonators
Authors: Grosman Arieh , Duanis-Assaf Tal , Mazurski Noa , Zektzer Roy , Frydendahl Christian , Stern Liron , Reches Meital , Levy Uriel 
Published: April 2023

Abstract
Coronavirus disease 2019 (COVID-19) is a newly emerging human infectious disease that continues to develop new variants. A crucial step in the quest to reduce the infection is the development of rapid and reliable virus detectors. Here, we report a chip scale photonic sensing device consisting of a silicon-nitride double microring resonator (MRR) for detecting SARS-CoV-2 in clinical samples. The sensor is implemented by surface activation of one of the MRRs, acting as a probe, with DNA primers for SARS-CoV-2 RNA, whereas the other MRR is used as a reference. The performance of the sensor is determined by applying different amounts of SARS-CoV-2 complementary RNA. As will be shown in the paper, our device detects the RNA fragments at concentrations of 10 cp/μL and with sensitivity of 750 nm/RIU. As such, it shows a promise toward the implementation of label-free, small form factor, CMOS compatible biosensor for SARS-CoV-2, which is also environment, temperature, and pressure independent. Our approach can also be used for detecting other SARS-CoV-2 genes, as well as other viruses and pathogens.
A Primer on Green Finance: From Wishful Thinking to Marginal Impact
Authors: Krahnen Jan , Rocholl Jörg , Thum Marcel 
Published: April 2023

Abstract
We raise some critical points against a naïve interpretation of “green finance” products and strategies. These critical insights are the background against which we take a closer look at instruments and policies that might allow green finance to become more impactful. In particular, we focus on the role of a taxonomy and investor activism. We also describe the interaction of government policies with green finance practice – an aspect, which has been mostly neglected in policy debates but needs to be taken into account. Finally, the special case of green government bonds is discussed.
Bi‐allelic pathogenic variants in PABPC1L cause oocyte maturation arrest and female infertility
Authors: Wang Weijie , Guo Jing , Shi Juanzi , Li Qun , Chen Biaobang , Pan Zhiqi , Qu Ronggui , Fu Jing , Shi Rong , Xue Xia , Mu Jian , Zhang Zhihua , Wu Tianyu , Wang Wenjing , Zhao Lin , Li Qiaoli , He Lin , Sun Xiaoxi , Sang Qing , Lin Ge , Wang Lei 
Published: April 2023

AbstractOocyte maturation arrest is one of the important causes of female infertility, but the genetic factors remain largely unknown. PABPC1L, a predominant poly(A)‐binding protein in Xenopus, mouse, and human oocytes and early embryos prior to zygotic genome activation, plays a key role in translational activation of maternal mRNAs. Here, we identified compound heterozygous and homozygous variants in PABPC1L that are responsible for female infertility mainly characterized by oocyte maturation arrest in five individuals. In vitro studies demonstrated that these variants resulted in truncated proteins, reduced protein abundance, altered cytoplasmic localization, and reduced mRNA translational activation by affecting the binding of PABPC1L to mRNA. In vivo, three strains of Pabpc1l knock‐in (KI) female mice were infertile. RNA‐sequencing analysis showed abnormal activation of the Mos‐MAPK pathway in the zygotes of KI mice. Finally, we activated this pathway in mouse zygotes by injecting human MOS mRNA, and this mimicked the phenotype of KI mice. Our findings reveal the important roles of PABPC1L in human oocyte maturation and add a genetic potential candidate gene to be screened for causes of infertility.
Olha quem está falando!
Authors: Tomaz Renata 
Published: April 2023

Este artigo se origina de pesquisa mais ampla que analisa de que modo o conteúdo noticioso on-line enquadra a visibilidade de crianças youtubers. A proposta geral é compreender em que medida o protagonismo digital delas torna suas vozes mais audíveis quanto a suas demandas geracionais, no debate público. Para tanto, a investigação apresenta uma análise de conteúdo aplicada a uma amostra de 52 notícias publicadas em páginas da internet brasileira, entre 2017 e 2019. Os resultados parciais indicam que as matérias analisadas reconhecem as crianças como sujeitos e atores de uma dinâmica social. No entanto, os assuntos pautados tendem a vincular suas vozes a marcadores sociais fortemente alinhados a valores neoliberais, restringindo essa cobertura a aspectos como fama e riqueza.
Islamic Education System for Elderly Islamic Boarding School in Cikarang, West Java
Authors: Chaedar Muhammad Rusmin , Syah Muhibbin , Ahmad Nurwadjah 
Published: April 2023

Some of the elderly feel themselves as marginalized in social life, because of a decline in physical and mental abilities. So not a few who experience depression because of their weak faith. Therefore, intensive religious training is needed for them. One of the institutions for the religious development of the elderly is a boarding school which specifically fosters the elderly. This study aims to analyze the elderly education program at the Daarul Fikri Integrated Islamic Boarding School , Cikarang Bekasi, West Java about the basic values of the elderly pesantren; The purpose of the pesantren for the elderly; Characteristics of elderly Islamic boarding school students; Elderly boarding school program; Elderly islamic boarding school materials; Elderly boarding school method; Impact and evaluation of learning on religious understanding of the elderly. This study uses a qualitative approach with a descriptive method. The data collection technique uses observation, interview, and documentation techniques. Meanwhile, the analysis method goes through several stages, namely: data reduction, data presentation, and verification and drawing conclusions. The results of the study show: 1) The basic values of the elderly pesantren are support for the elderly to be able to live independently; 2) Islamic boarding schools for the elderly were established to accommodate the elderly who want to deepen their religious knowledge and seek inner peace; 3) Elderly students have special characteristics; 4) The elderly pesantren program is only held for one week for each generation; 5) The teaching materials in Islamic boarding schools for the elderly are the Qur'an, Islamic studies (Tawhid, Tafsir, Fiqh, akhlaq (islamic morality), tashihul worship, riyadloh / sports / natural meditation, worship guidance, dhikr, and morals. 6) The learning methods used in Islamic boarding schools for the elderly are discussions and lectures; 7) Elderly pesantren alumni feel an increase in religious insight and are diligent in establishing friendships. While the evaluation is focused on the implementation of the Islamic boarding school for the elderly.
The health/power/criminality-nexus in the state of exception
Authors: Ahearne Gemma , Freudenthal Robert 
Published: April 2023

The positioning of the ‘other’ as a dangerous vector of disease is a long-standing trope. This has existed both in racial terms, such as the 1905 Aliens Act, and for others positioned as on the outliers of society, such as sex workers, under the Contagious Diseases Acts 1864, 1866, 1869 (Hamilton, 1978). The public health system has long been used as a system of control, alongside its self-described role as existing for the betterment of population health. Similarly, other aspects of our health system have long functioned both as a foundational part of the welfare state, and as key perpetrators of racial injustice and part of the carceral state. This is most obvious in the psychiatric system, where there continues to be a disproportionate detention of black men (Singh, 2007). Injustice, surveillance, and even mass detention, that is enacted within a health systems framework is rarely given the same critical focus as other systems of power, such as the criminal justice system – which has been highlighted by the reality that various recent reports into racial discrimination only give a brief mention to the role of healthcare systems in perpetrating various injustices (Equality and Human Rights Commission, 2016). During the pandemic the healthcare system has increasingly been used as a justification for advancing a state apparatus of biopower, and has experienced little resistance from the organised left.
An economic evaluation of presymptomatic Sars-Cov-2 (COVID-19) detection using anomaly detection models in the COVID-RED Trial
Authors: Korkmaz Serkan , Hansen Paul Lynggård , Kjellberg Jakob 
Published: April 2023

Abstract
Background: There is an average 5 day delay between a COVID-19 infection and symptom onset. Evidence suggests between 35% and 50% of all transmissions occur within this time-frame. Presymptomatic COVID-19 detection, therefore, serves a crucial role in containing the spread of COVID-19. An early COVID-19 detection algorithm were developed in the COVID-Red trial, which based on anomalies in biophysical markers, measured via a bracelet, predicts COVID-19 infection.
Method: This paper is an economic evaluation of the anomaly detection model developed in the COVID-Red trial with a health sector perspective. The primary outcome is the incremental cost effectiveness ratio (ICER), where the effectiveness is measured as early COVID-19 detection. Data on healthcare utilisation and COVID-19 testing are collected through biweekly surveys, structured phone interviews and a daily symptom diary. All data is self reported.
Results: COVID-19 can be detected 3.50 days earlier using an anomaly detection model, as opposed to a deterministic approach. The associated costs are ­≈54€ and ≈50€, on average, in the intervention and control group respectively. The ICER is 1.15€, and implies a marginal cost of 1.15€ per days of early detection.
Conclusion: The anomaly detection model detects COVID-19 3.5 earlier than otherwise possible, with a marginal cost of 4€. The ICER is 1.15€. Compared to the existing test strategies, the bracelet and algorithm combination is expensive. It can be considered inexpensive amongst, for example, healthcare workers where structured COVID-19 screenings are common.
Trial registration: Dutch Trial Register, NL9320. Registered 18/02/2021, https://clinicaltrialregister.nl/en/trial/23180