bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of recurrence based on intravascular ultrasound findings after Eluvia placement in symptomatic peripheral arterial disease: A retrospective study
Authors: Yamada Takehiro , Tokuda Takahiro , Yoshioka Naoki , Koyama Akio , Nishikawa Ryusuke , Shimamura Kiyotaka , Aoyama Takuma 
Published: August 2023

AbstractBackground and AimsPolymer‐coated drug‐eluting stents (Eluvia) have shown favorable clinical outcomes in real‐world registries. There are no reports on recurrent predictors after Eluvia placement based on intravascular ultrasound (IVUS) findings.MethodsWe analyzed clinical data from the ASIGARU PAD registry, a retrospective, multicenter, observational study that enrolled patients who underwent endovascular therapy for superficial femoral and proximal popliteal arteries lesions using Eluvia or drug‐coated balloon. The primary outcome was the identification of recurrent predictors, including IVUS parameters at 12 months. The rate of target lesion recurrence was also assessed.ResultsIVUS images were obtained in 54 of 65 cases. Seven recurrent cases (13.0%) were observed within 12 months. The random survival forest method presented eight predictive variables of recurrence: Clinical Frailty Scale (CFS), distal stent edge area, distal plaque burden, age, sex, distal external elastic membrane (EEM) area, minimum stent area (MSA), and distal lumen area. Furthermore, the partial dependence plot showed that frailty (CFS ≥ 6), smaller distal stent edge area, higher and lower distal plaque burden, older and younger age, female sex, smaller distal EEM area, smaller MSA, and smaller and larger distal lumen area predicted recurrence after Eluvia placement within 12 months.ConclusionCFS, distal stent edge area, distal plaque burden, age, sex, distal EEM area, MSA, and distal lumen area were significant recurrent predictors after Eluvia placement.
Chasing assets abroad: Ideas for more effective asset tracing and recovery in cross‐border insolvency
Authors: Sarra Janis , Madaus Stephan , Mevorach Irit 
Published: August 2023

AbstractAsset tracing and recovery (ATR) has become highly challenging in the digital age, where, with the touch of computer keys, assets can be shifted through multiple jurisdictions within minutes, creating significant challenges for recovering value. While many countries have tools to enable ATR, these tools differ from jurisdiction to jurisdiction and often are not recognized across borders in a manner that keeps pace with the need for rapid ATR, particularly during insolvency. This article takes stock of the myriad ATR tools available in domestic systems to discern parameters of key ATR tools that have common objectives, features, and safeguards, and that can form the basis of more standardized understanding and application of such tools. It also explores the extent to which cross‐border ATR is aided by the leading frameworks for global, cross‐border insolvency—the UNCITRAL Model Laws on Cross‐Border Insolvency, insolvency‐related judgments, and enterprise groups—in the process, revealing gaps and uncertainties. Such uncertainties can result in losses to stakeholders affected by insolvencies of different business sizes but can be particularly detrimental in small and medium enterprise (SME) cross‐border insolvencies where there are typically more limited resources to chase assets. Against this backdrop, this article proposes ideas for the enhancement of the cross‐border insolvency framework, to allow for effective cross‐border access to information held abroad, the freezing of assets in cross‐border cases, and the cross‐border recovery of assets.
Genome‐wide study of genetic polymorphisms predictive for outcome from first‐line oxaliplatin‐based chemotherapy in colorectal cancer patients
Authors: Park Hanla A. , Edelmann Dominic , Canzian Federico , Seibold Petra , Harrison Tabitha A. , Hua Xinwei , Shi Qian , Silverman Allison , Benner Axel , Macauda Angelica , Schneider Martin , Goldberg Richard M. , Alberts Steven R. , Hoffmeister Michael , Brenner Hermann , Chan Andrew T. , Peters Ulrike , Newcomb Polly A. , Chang‐Claude Jenny 
Published: August 2023

AbstractWe conducted the first large genome‐wide association study to identify novel genetic variants that predict better (or poorer) prognosis in colorectal cancer patients receiving standard first‐line oxaliplatin‐based chemotherapy vs chemotherapy without oxaliplatin. We used data from two phase III trials, NCCTG N0147 and NCCTG N9741 and a population‐based patient cohort, DACHS. Multivariable Cox proportional hazards models were employed, including an interaction term between each SNP and type of treatment for overall survival (OS) and progression‐free survival. The analysis was performed for studies individually, and the results were combined using fixed‐effect meta‐analyses separately for resected stage III colon cancer (3098 patients from NCCTG N0147 and 549 patients from DACHS) and mCRC (505 patients from NCCTG N9741 and 437 patients from DACHS). We further performed gene‐based analysis as well as in silico bioinformatics analysis for CRC‐relevant functional genomic annotation of identified loci. In stage III colon cancer patients, a locus on chr22 (rs11912167) was associated with significantly poorer OS after oxaliplatin‐based chemotherapy vs chemotherapy without oxaliplatin (Pinteraction < 5 × 10−8). For mCRC patients, three loci on chr1 (rs1234556), chr12 (rs11052270) and chr15 (rs11858406) were found to be associated with differential OS (P < 5 × 10−7). The locus on chr1 located in the intronic region of RCSD1 was replicated in an independent cohort of 586 mCRC patients from ALGB/SWOG 80405 (Pinteraction = .04). The GWA gene‐based analysis yielded for RCSD1 the most significant association with differential OS in mCRC (P = 6.6 × 10−6). With further investigation into its biological mechanisms, this finding could potentially be used to individualize first‐line treatment and improve clinical outcomes.
Reflections on access to care for heavy menstrual bleeding: Past, present, and in times of the COVID‐19 pandemic
Authors: Henry Claire , Filoche Sara 
Published: August 2023

AbstractThe symptom of heavy menstrual bleeding (HMB) affects at least a quarter of reproductive‐age menstruators. However, given the variance in diagnosing the underlying causes, barriers, and inequity in access to care for HMB, and therefore reporting of HMB, this figure is likely to be a gross underestimate. HMB can have a detrimental impact on quality of life. From the limited reports available it is estimated that around 50%–80% of people with HMB do not seek care for this debilitating symptom, and for those that do, it may take years until the first treatment action. Almost half of those with HMB believe their condition is unworthy of treatment, that there is no treatment available, or that it is “normal”. The term “medical gaslighting” has recently been used to describe how healthcare professionals disregard people's symptoms. This has the ensuing effect of negatively compounding self‐doubt and embarrassment around menstrual bleeding, creating a cycle of diminished experience inhibiting further seeking of care. There is a scarcity of intervention studies informing increased access to care. Multilevel approaches are needed to increase access to care and support for those with HMB. During the COVID‐19 global pandemic, barriers to care access and support for HMB have been exacerbated and, given the significant pressures that this pandemic has placed on healthcare services worldwide, it will take many years to recover. In the meantime, it is crucial to ensure that medically “benign” conditions such as the symptom of HMB are not overlooked.
Clinical efficacy and risk factors for suction curettage and hysteroscopy in patients with type I and II cesarean scar pregnancy
Authors: Wu Tong , Wang Qingxuan , Liu Wei , Zhang Jing , Wang Wenhui , Wang Jun , Ji Cuihong , Liu Honghui , Tang Chunyan , Mi Xin 
Published: August 2023

AbstractObjectiveTo investigate the clinical efficacy and evaluate risk factors for suction curettage (SC) and hysteroscopy in the treatment of type I and II cesarean scar pregnancy (CSP).MethodsThis was a retrospective study including 100 women diagnosed with type I/II CSP. Patients were treated with either ultrasound‐guided SC (SC group) or hysteroscopy resection (surgery group). The success rates, mean operation time, hospitalization duration, hospitalization cost, risk factors, adverse events, and complications were analyzed.ResultsThe success rate of the SC and surgery groups were 85% and 100%, respectively, and the difference was statistically significant (P = 0.032). There was one case of type I CSP and eight cases of type II CSP that failed SC treatment. No failed cases were found in the surgery group. Analysis of the causes of treatment failure revealed that diameter of the gestational sac was a risk factor for SC failure (odds ratio, 19.66 [95% confidence interval {CI}, 1.70–227.72], P = 0.017). Comparing the clinical outcomes between the SC and surgery groups, although the mean operation time of the SC group was significantly shorter than the surgery group (15 [CI, 15–20] vs. 30 [CI, 27–40], P = 0.001), the cost and duration of hospitalization were significantly lower in the surgery group than that in the SC group. No significant differences were observed for adverse events and complications between the two groups (P > 0.05).ConclusionHysteroscopy is an effective and economical method for treating type I/II CSP. Moreover, SC is not recommended for patients with type I/II CSP with a gestation age ≥8 weeks.
The effectiveness of a novel treatment of TIM‐3(−) NK cells infusion in murine models of immune‐mediated bone marrow failure
Authors: Ding Shaoxue , Zhang Tian , Liu Zixuan , Cui Yi , Liu Chunyan , Fu Rong 
Published: August 2023

AbstractBackgroundT‐cell immunoglobulin and mucin‐containing domain (TIM)‐3 exerts its inhibitory effect on NK cells and participates in the immune pathogenesis of SAA. In this study, we aimed to explore a novel treatment method of TIM‐3(+) NK or TIM‐3(−) NK cell infusion in combination with immunosuppressive therapy for bone marrow failure (BMF)/aplastic anemia (AA) mice.MethodsBMF/AA mouse model was constructed. The TIM‐3 expression and functional molecules on TIM‐3(+) and TIM‐3(−) NK cells of the BMF group, total body irradiation (TBI) group, and normal control (NC) group mice were detected by flow cytometry. After treatment, the general condition, whole blood cell and bone marrow cell (BMC) count, and immune condition of mice from each group were compared.ResultsTIM‐3 expression in the peripheral blood NK cells of BMF mice was significantly lower than that of the TBI and NC group mice. TIM‐3(−) NK cells expressed more NKG2D receptors than TIM‐3(+) NK cells. The levels of P‐Akt and PI3K in TIM‐3(−) NK cells were higher than those in TIM‐3(+) NK cells. On the 17th day after BMF induction, the weight, peripheral whole blood cell count, and BMC count of BMF mice decreased significantly compared with that of the NC group mice. The therapeutic effect in the TIM‐3(−) NK cell treatment group was better than that in the TIM‐3(+) NK cell treatment and CsA treatment groups. Concurrently, the ratio of CD4+T and CD8+T cells of BMF mice was significantly lower than that of the NC group mice. The therapeutic effect in CsA + TIM‐3(−) NK group was more significant than that of the CsA treatment and the CsA + TIM‐3(+) NK groups.ConclusionsIn this study, we found that the general condition, peripheral whole blood cell and BMC count, and immune status of BMF mice improved significantly after CsA + TIM‐3(−) NK cell treatment. These results may provide further insights into the immune pathogenesis of SAA and novel therapeutic ideas for improving SAA treatment.
Correlation between different levels and patterns of dyslipidemia and glomerular filtration rate in patients with type 2 diabetes: A cross‐sectional survey of a regional cohort
Authors: Yadegar Amirhossein , Mohammadi Fatemeh , Rabizadeh Soghra , Ayati Aryan , Seyedi Seyed Arsalan , Nabipoorashrafi Seyed Ali , Esteghamati Alireza , Nakhjavani Manouchehr 
Published: August 2023

AbstractBackgroundDue to the high cardiovascular risk in patients with diabetic nephropathy, more attention should be paid to lipid levels and dyslipidemia in these patients. The current study investigated the association between single and mixed dyslipidemia patterns, estimated glomerular filtration rate (eGFR), and different chronic kidney disease (CKD) stages.MethodsThis cross‐sectional study evaluated 4059 patients with type 2 diabetes (T2D). TG, TC, LDL‐C, and HDL‐C were measured. Non‐HDL‐C and AIP were calculated. We estimated eGFR using the CKD‐EPI equation.ResultsWith the progression of the kidney failure stage, mean levels of TG, LDL‐C, non‐HDL‐C, and AIP decreased. HDL‐C levels decreased with the advance of the CKD stage in men but did not change significantly in women. The prevalence of single dyslipidemia, including high LDL‐C and high non‐HDL‐C, decreased with the advancing CKD stage. The prevalence of mixed dyslipidemia patterns, including high AIP and high LDL‐C, high AIP and high non‐HDL‐C, showed a significant downward tendency. TG and AIP levels were negatively, and HDL‐C levels were positively correlated with eGFR after adjusting for the risk factors. Also, CKD stage 3 was positively related to the risk of high TG and low HDL‐C.ConclusionThis study shows that blood lipids decreased with the progression of renal failure in patients with T2D. However, after adjustment, TG and AIP levels had negative, and HDL‐C levels had a positive correlation with eGFR, which could be consistent with the hypothesis that eGFR decreases with increasing TG or AIP levels or decreasing HDL‐C levels.
Beyond genetics: Deciphering the impact of missense variants in CAD deficiency
Authors: del Caño‐Ochoa Francisco , Ng Bobby G. , Rubio‐del‐Campo Antonio , Mahajan Sonal , Wilson Matthew P. , Vilar Marçal , Rymen Daisy , Sánchez‐Pintos Paula , Kenny Joanna , Ley Martos Myriam , Campos Teresa , Wortmann Saskia B. , Freeze Hudson H. , Ramón‐Maiques Santiago 
Published: August 2023

AbstractCAD is a large, 2225 amino acid multienzymatic protein required for de novo pyrimidine biosynthesis. Pathological CAD variants cause a developmental and epileptic encephalopathy which is highly responsive to uridine supplements. CAD deficiency is difficult to diagnose because symptoms are nonspecific, there is no biomarker, and the protein has over 1000 known variants. To improve diagnosis, we assessed the pathogenicity of 20 unreported missense CAD variants using a growth complementation assay that identified 11 pathogenic variants in seven affected individuals; they would benefit from uridine treatment. We also tested nine variants previously reported as pathogenic and confirmed the damaging effect of seven. However, we reclassified two variants as likely benign based on our assay, which is consistent with their long‐term follow‐up with uridine. We found that several computational methods are unreliable predictors of pathogenic CAD variants, so we extended the functional assay results by studying the impact of pathogenic variants at the protein level. We focused on CAD's dihydroorotase (DHO) domain because it accumulates the largest density of damaging missense changes. The atomic‐resolution structures of eight DHO pathogenic variants, combined with functional and molecular dynamics analyses, provided a comprehensive structural and functional understanding of the activity, stability, and oligomerization of CAD's DHO domain. Combining our functional and protein structural analysis can help refine clinical diagnostic workflow for CAD variants in the genomics era.
Predictors of implantation failure in left bundle branch area pacing using a lumenless lead in patients with bradycardia
Authors: Kato Hiroyuki , Sato Toshiaki , Shimeno Kenji , Mito Shinji , Nishida Taku , Soejima Kyoko 
Published: August 2023

AbstractBackgroundLeft bundle branch area pacing (LBBAP) is a novel conduction system pacing technique. In this multicenter study, we aimed to evaluate the procedural success, safety, and preoperative predictors of procedural failure of LBBAP.MethodsLBBAP was attempted in 285 patients with pacemaker indications for bradyarrhythmia, which were mainly atrioventricular block (AVB) (68.1%) and sick sinus syndrome (26.7%). Procedural success and electrophysiological and echocardiographic parameters were evaluated.ResultsLBBAP was successful in 247 (86.7%) patients. Left bundle branch (LBB) capture was confirmed in 54.7% of the population. The primary reasons for procedural failure were the inability of the pacemaker lead to penetrate deep into the septum (76.3%) and failure to achieve shortening of stimulus to left ventricular (LV) activation time in lead V6 (18.4%). Thickened interventricular septum (odds ratio [OR], 2.48; 95% confidence interval [CI], 1.15–5.35), severe tricuspid regurgitation (OR, 8.84; 95% CI, 1.22–64.06), and intraventricular conduction delay (OR, 8.16; 95% CI, 2.32–28.75) were preoperative predictors of procedural failure. The capture threshold and ventricular amplitude remained stable, and no major complications occurred throughout the 2‐year follow‐up. In patients with ventricular pacing burden >40%, the LV ejection fraction remained high regardless of LBB capture.ConclusionsSuccessful LBBAP was affected by abnormal cardiac anatomy and intraventricular conduction. LBBAP is feasible and safe as a primary strategy for patients with AVB, depending on ventricular pacing.
Otolaryngologic Side Effects After COVID‐19 Vaccination
Authors: Ahsanuddin Salma , Jin Ryan , Dhanda Aatin K. , Georges Kirolos , Baredes Soly , Eloy Jean Anderson , Fang Christina H. 
Published: August 2023

ObjectivesWith widespread vaccination against COVID‐19, concerns regarding side effects have been raised. We aim to assess the frequency of otolaryngologic adverse events (AEs) following COVID‐19 vaccination as compared with other vaccines in a national database.Study DesignRetrospective analysis of national registry.MethodsThe Food and Drug Administration's Vaccine Adverse Event Reporting System (VAERS) database was queried from December 2020 to May 2021 for all COVID‐19 vaccination AEs. Complaints were categorized as otolaryngologic and sub stratified into different anatomic components. Reporting odds ratios (ROR) and proportional reporting ratios (PRR) were determined for AEs of clinical significance.ResultsThe total number of AEs reported from vaccination with the Moderna, Pfizer‐BioNTech, and Janssen vaccines equaled 1,280,950. Of these, 62,660 (4.9%) were otolaryngologic in nature, with 32.6% associated with the oropharynx/larynx, 18.3% with the nasal cavity/sinuses, 17.1% with the ears/vestibular system, 10.0% with the oral cavity, and 21.9% miscellaneous. Signal ratios reached significance levels for dysgeusia (n = 2124, PRR: 17.33, ROR: 16.36), ageusia (n = 1376, PRR: 2.81, ROR: 2.81), anosmia (n = 983, PRR: 4.01, ROR: 4.01), rhinorrhea (n = 2203, PRR: 2.99, ROR: 3.00), throat tightness (n = 3666, PRR: 4.99, ROR: 5.00), throat irritation (n = 3313, PRR: 4.51, ROR: 4.52), dysphagia (n = 2538, PRR: 2.07, ROR: 2.07), tinnitus (n = 4377, PRR: 3.97, ROR: 3.98), and vertigo (n = 2887, PRR: 3.93, ROR: 3.93). Signal ratios were not significant for facial paralysis, Bell's palsy, anaphylaxis, sinusitis, hearing disability, and ear pain.ConclusionsAlthough several otolaryngologic symptoms were reported, few were found to be clinically significant. Of note, facial paralysis, Bell's palsy, and anaphylaxis did not meet signal thresholds to be determined significant.Level of Evidence4 Laryngoscope, 134:1163–1168, 2024
Spatially varying plankton synchrony patterns at seasonal and interannual scales in a well‐connected shelf sea
Authors: Honda Isabel A. , Ji Rubao , Solow Andrew R. 
Published: August 2023

AbstractSpatial population synchrony, defined as spatial covariation in population density fluctuations, exists across different temporal and spatial scales. Determining the degree of spatial synchrony is useful for inferring environmental drivers of population variability in the wake of climate change. In this study, we applied novel statistical methods to detect spatial synchrony patterns of Calanus finmarchicus on the Northeast U.S. Shelf at multiple spatiotemporal scales using unevenly distributed data. Our results reveal that C. finmarchicus subpopulations connected by advection are not necessarily in synchrony, indicating that the degree of synchrony is likely influenced by heterogeneity of local habitats. In addition, regionally synchronous environmental conditions (e.g., sea surface temperature) may not play as significant a role in influencing subregional population dynamics as was previously hypothesized. Overlooking the spatial heterogeneity of synchronous patterns at different time scales could lead to erroneous inferences of potential environmental drivers responsible for C. finmarchicus variability.
Implications of Low‐Refractive Mode Index on Nonlinear Optical Interactions
Authors: Vertchenko Larissa , Lavrinenko Andrei 
Published: August 2023

AbstractDespite ample experimental evidence that the so‐called epsilon‐near‐zero (ENZ) materials enable enhancement of nonlinear interactions in limited volumes of materials, there is still a lot of controversy about theoretical interpretation of results in search of optimal materials and structural configurations. The nonlinear performance of materials depending on their refractive index is compared and direct simulations prove with the indium‐tin oxide material that the regime with low refractive index is superior to the ENZ regime in terms of the third harmonic generation (THG) efficiency. It is shown that as a rule for low‐index materials the THG scales inversely proportional to the refractive index squared. Another advantage of low‐index modes is that they satisfy phase‐matching conditions by default. As exemplified by the direct numerical simulations, silicon‐based photonic crystals can effectively produce third harmonic waves, which can be manipulated to propagate in any desired direction. Such an approach helps to avoid unnecessary complexity in on‐chip linear and nonlinear circuitry and reduces potential sources of losses by unifying the whole production chain with implementation of the same material, e.g., silicon.