bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual dimorphism in peripheral blood cell characteristics linked to recanalization success of endovascular thrombectomy in acute ischemic stroke
Authors: Overmars L. Malin , van Solinge Wouter W. , Ruijter Hester M. den , van der Worp H. Bart , Van Es Bram , Hulsbergen-Veelken Cornelia A. R. , Biessels Geert Jan , Exalto Lieza G. , Haitjema Saskia 
Published: August 2023

AbstractEndovascular thrombectomy (EVT) success to treat acute ischemic stroke varies with factors like stroke etiology and clot composition, which can differ between sexes. We studied if sex-specific blood cell characteristics (BCCs) are related to recanalization success. We analyzed electronic health records of 333 EVT patients from a single intervention center, and extracted 71 BCCs from the Sapphire flow cytometry analyzer. Through Sparse Partial Least Squares Discriminant Analysis, incorporating cross-validation and stability selection, we identified BCCs associated with successful recanalization (TICI 3) in both sexes. Stroke etiology was considered, while controlling for cardiovascular risk factors. Of the patients, successful recanalization was achieved in 51% of women and 49% of men. 21 of the 71 BCCs showed significant differences between sexes (pFDR-corrected < 0.05). The female-focused recanalization model had lower error rates than both combined [t(192.4) = 5.9, p < 0.001] and male-only models [t(182.6) = − 15.6, p < 0.001]. In women, successful recanalization and cardioembolism were associated with a higher number of reticulocytes, while unsuccessful recanalization and large artery atherosclerosis (LAA) as cause of stroke were associated with a higher mean corpuscular hemoglobin concentration. In men, unsuccessful recanalization and LAA as cause of stroke were associated with a higher coefficient of variance of lymphocyte complexity of the intracellular structure. Sex-specific BCCs related to recanalization success varied and were linked to stroke etiology. This enhanced understanding may facilitate personalized treatment for acute ischemic stroke.
Serpina3n/serpina3 alleviates cyclophosphamide-induced interstitial cystitis by activating the Wnt/β-catenin signal
Authors: Fang Weilin , Song Qixiang , Lv Tingting , Lv Jianwei , Cai Zhikang , Wang Zhong , Song Xin , Ji Xiang , Huang Jin 
Published: August 2023

Abstract
Background/objective
Serpina3n/Serpina3 has been identified to be implicated in inflammatory diseases, but its role in interstitial cystitis/bladder pain syndrome (IC/BPS) remains unknown. Here, we aimed to reveal serpina3n/serpina3 role in IC/BPS in vivo and in vitro.

Methods
The IC/BPS model in mice was induced by intraperitoneal injection of 150 mg/kg of cyclophosphamide (CYP). HE and toluidine blue staining were used for histology assessment. Serpina3n/serpina3 expression in the bladder tissues from IC/BPS patients and mouse models were determined by qPCR, immunohistochemistry and western blotting. XAV-939 treatment was applied to inhibit β-catenin activation. Serpina3 role in modulating the growth and apoptosis of HBlEpCs, a human primary bladder epithelial cell line, was assessed by CCK-8 and flow cytometry assays.

Results
Serpina3n/serpina3 expression was decreased in both human and mice bladder tissues with IC/BPS. Upregulation of serpina3n significantly alleviated CYP-induced bladder injury, with decreased mast cells and pro-inflammatory factor levels, including IL-1β, IL-6, and TNF-α, while increased IL-10 level. In addition, serpina3 overexpression inhibited the apoptosis of HBlEpCs, and increased cell growth. In mechanism, we found that serpina3 overexpression promoted the activation of wnt/β-catenin signaling. And, the inhibition of wnt/β-catenin signaling with XAV-939 abolished serpina3n/serpina3 role in protecting bladder tissues from CYP-induced cystitis, as well as inhibiting HBlEpC apoptosis.

Conclusion
Serpina3n/serpina3 expression was decreased in IC/BPS. Overexpression of serpina3n could alleviate CYP-induced IC/BPS by activating the Wnt/β-catenin signal. This study may provide a new therapeutic strategy for IC/BPS.
Investigating state and trait aspects of resilience using Generalizability theory
Authors: Child Lucy E. , Medvedev Oleg N. 
Published: August 2023

AbstractChallenges of modern living such as burden of disease, a global COVID-19 pandemic and workplace stress leading to anxiety and depression raise the importance of psychological resilience. Psychological interventions should increase trait resilience that involves reinforcing state resilience and requires a clear distinction between state and trait aspects of the construct. Generalizability theory is the appropriate method increasingly used to distinguish between state and trait and to establish reliability of psychological assessment. G-theory was applied to examine five major resilience scales completed at 3 time-points by the sample (n = 94) that possess adequate statistical power for such analyses. All five resilience scales demonstrated strong reliability and generalizability of scores across occasions and sample population as expected for a valid trait measure (G > 0.90). However, eight state aspects of resilience were identified from all five resilience scales including adaptation to change; perseverance; self-confidence while facing adversity; self-efficacy; trust in instincts; ability to follow plans; non-reactivity; and ability to plan. State aspects of resilience appear to show more variability and, pending further research, could potentially be a target for resilience-building interventions. All five measures of resilience are useful to assess long-lasting changes in resilience. Development of a state resilience scale is warranted.
Potato Tuber Lenticels: A Review of Their Development, Structure, Function, and Disease Susceptibility
Authors: Bethke Paul Carl 
Published: August 2023

AbstractPotato tuber lenticels are essential components of the potato skin. This review draws on more than a century of published literature to give a comprehensive overview of potato tuber lenticels. This review describes the development and structure of lenticels, as well as the number of lenticels per tuber. Lenticels facilitate gas exchange between the atmosphere and the interior of the tuber, and data on lenticel permeability to oxygen and carbon dioxide are summarized. Conditions that promote proliferation of filling cells and lenticel enlargement are described in the context of laboratory experiments and observations from the field. Lenticels are potential sites of infection by plant pathogens including common scab, powdery scab and late blight. Research demonstrating interactions between lenticels and various diseases is presented, with an emphasis on potato soft rot. Many aspects of lenticel biology remain poorly understood and a few compelling unanswered questions are highlighted.
An improved blood hemorrhaging treatment using diatoms frustules, by alternating Ca and light levels in cultures
Authors: Li Qinfeng , He Zheng , Rozan Hussein. E. , Feng Chao , Cheng Xiaojie , Chen Xiguang 
Published: August 2023

AbstractHemorrhage control requires hemostatic materials that are both effective and biocompatible. Among these, diatom biosilica (DBs) could significantly improve hemorrhage control, but it induces hemolysis (the hemolysis rate > 5%). Thus, the purpose of this study was to explore the influence of Ca2+ biomineralization on DBs for developing fast hemostatic materials with a low hemolysis rate. Here, CaCl2 was added to the diatom medium under high light (cool white, fluorescent lamps, 67.5 µmol m−2 s−1), producing Ca-DBs-3 with a particle size of 40–50 μm and a Ca2+ content of Ca-DBs-3 obtained from the higher concentration CaCl2 group (6.7 mmol L−1) of 0.16%. The liquid absorption capacity of Ca-DBs-3 was 30.43 ± 0.57 times its dry weight; the in vitro clotting time was comparable to QuikClot® zeolite; the hemostatic time and blood loss using the rat tail amputation model were 36.40 ± 2.52 s and 0.39 ± 0.12 g, which were 40.72% and 19.50% of QuikClot® zeolite, respectively. Ca-DBs-3 showed no apparent toxicity to L929 cells (cell viability > 80%) and was non-hemolysis (the hemolysis rate < 2%). This study prepared Ca-DBs-3 with a rapid hemostatic effect and good biocompatibility, providing a path to develop diatom biosilica hemostatic materials.
Large yellow croaker (Larimichthys crocea) mitofusin 2 inhibits type I IFN responses by degrading MAVS via enhanced K48-linked ubiquitination
Authors: Li Wen-Xing , Wang Xiao-Hong , Lin Yi-Jun , Zhou Yuan-Yuan , Li Jun , Zhang Xiang-Yang , Chen Xin-Hua 
Published: August 2023

AbstractIn mammals, mitofusin 2 (MFN2) is involved in mitochondrial fusion, and suppresses the virus-induced RIG-I-like receptor (RLR) signaling pathway. However, little is known about the function of MFN2 in non-mammalian species. In the present study, we cloned an MFN2 ortholog (LcMFN2) in large yellow croaker (Larimichthys crocea). Phylogenetic analysis showed that MFN2 emerged after the divergence of amphioxus and vertebrates. The protein sequences of MFN2 were well conserved from fish to mammals. LcMFN2 was expressed in all the tissues/organs examined at different levels, and its expression was upregulated in response to poly(I:C) stimulation. Overexpression of LcMFN2 inhibited MAVS-induced type I interferon (IFN) promoter activation and antiviral gene expression. In contrast, knockdown of endogenous LcMFN2 enhanced poly(I:C) induced production of type I IFNs. Additionally, LcMFN2 enhanced K48-linked polyubiquitination of MAVS, promoting its degradation. Also, overexpression of LcMFN2 impaired the cellular antiviral response, as evidenced by the increased expression of viral genes and more severe cytopathic effects (CPE) in cells infected with spring viremia of carp virus (SVCV). These results indicated that LcMFN2 inhibited type I IFN response by degrading MAVS, suggesting its negative regulatory role in cellular antiviral response. Therefore, our study sheds a new light on the regulatory mechanisms of the cellular antiviral response in teleosts.
Evaluation of the effect of different conventional roof types and industrial activity on harvested rainwater in Southern Nigeria
Authors: Nicholas Eno-obong Sunday , Ukoha Pius Onyeoziri 
Published: August 2023

AbstractHarvested rainwater is still the only source of acceptable drinking water for rural communities in Nigeria and in some countries, where there are no water networks and it is the rooftop rainwater harvesting that is being exercised for the potable and non-potable usages. This study was aimed at evaluating the effect of roof types and industrial activity on rainwater quality by analysing the physico-chemical/bacteriological characteristics, heavy metals and investigating the metal composition of the roof types. Rainwater was harvested from long-span aluminium, asbestos, corrugated iron, Cameroon zinc, stone-coated tiles roof run-offs and directly from the sky in the urban and rural areas of Imo State between the months of April-July, 2017. The results were compared with water quality standards (NAFDAC, USEPA, WHO and NSDWQ) for drinking water and Water Quality Index (WQI) ratings since there is no standard for rainwater quality. Roofs ages from < 5, 5–10, 15–20, and > 25 years in use were considered. Heavy metals were analysed using Flame-AAS; other parameters were analysed using standard methods. The WQI ratings were calculated using the weighted arithmetic method. Results show mean values ranging from 5.70 to 6.60 for pH, E.coli (not detected) and heavy metals (mg/L) burden of 0.00–0.09 for Pb, Cr (0.00–0.79), Zn (0.00–0.06), Fe (0.00–0.50) and Al (0.00–0.63). The WQI ratings gave excellent water to unfit for drinking water quality in both urban and rural areas. Since the harvested rainwater was not free of contamination, a few helpful recommendations were suggested for positive impacts in Nigeria as a whole.
Generalized Ricci Solitons on Three-Dimensional Lorentzian Walker Manifolds
Authors: Pirhadi Vahid , Fasihi-Ramandi Ghodratallah , Azami Shahroud 
Published: August 2023

AbstractIn this paper, we characterize the generalized Ricci soliton equation on the three-dimensional Lorentzian Walker manifolds. We prove that every generalized Ricci soliton with $$C, \beta ,\mu \ne 0$$

C
,
β
,
μ
≠
0

on a three-dimensional Lorentzian Walker manifold is steady. Moreover, non-trivial solutions for strictly Lorentzian Walker manifolds are derived. Finally, we give some conditions on the defining function f under which a generalized Ricci soliton on a three-dimensional Lorentzian Walker manifold to be gradient.
Migration–contagion processes
Authors: Baccelli F. , Foss S. , Shneer S. 
Published: August 2023

AbstractConsider the following migration process based on a closed network of N queues with
$K_N$
customers. Each station is a
$\cdot$
/M/
$\infty$
queue with service (or migration) rate
$\mu$
. Upon departure, a customer is routed independently and uniformly at random to another station. In addition to migration, these customers are subject to a susceptible–infected–susceptible (SIS) dynamics. That is, customers are in one of two states: I for infected, or S for susceptible. Customers can swap their state either from I to S or from S to I only in stations. More precisely, at any station, each susceptible customer becomes infected with the instantaneous rate
$\alpha Y$
if there are Y infected customers in the station, whereas each infected customer recovers and becomes susceptible with rate
$\beta$
. We let N tend to infinity and assume that
$\lim_{N\to \infty} K_N/N= \eta $
, where
$\eta$
is a positive constant representing the customer density. The main problem of interest concerns the set of parameters of such a system for which there exists a stationary regime where the epidemic survives in the limiting system. The latter limit will be referred to as the thermodynamic limit. We use coupling and stochastic monotonicity arguments to establish key properties of the associated Markov processes, which in turn allow us to give the structure of the phase transition diagram of this thermodynamic limit with respect to
$\eta$
. The analysis of the Kolmogorov equations of this SIS model reduces to that of a wave-type PDE for which we have found no explicit solution. This plain SIS model is one among several companion stochastic processes that exhibit both random migration and contagion. Two of them are discussed in the present paper as they provide variants to the plain SIS model as well as some bounds and approximations. These two variants are the departure-on-change-of-state (DOCS) model and the averaged-infection-rate (AIR) model, which both admit closed-form solutions. The AIR system is a classical mean-field model where the infection mechanism based on the actual population of infected customers is replaced by a mechanism based on some empirical average of the number of infected customers in all stations. The latter admits a product-form solution. DOCS features accelerated migration in that each change of SIS state implies an immediate departure. This model leads to another wave-type PDE that admits a closed-form solution. In this text, the main focus is on the closed stochastic networks and their limits. The open systems consisting of a single station with Poisson input are instrumental in the analysis of the thermodynamic limits and are also of independent interest. This class of SIS dynamics has incarnations in virtually all queueing networks of the literature.
Excessive Pricing in Pharmaceuticals under Article 102 TFEU
Authors: Veraldi Jacquelyn D. 
Published: August 2023

AbstractHigh pharmaceutical pricing practices in Europe have been increasingly on the radar of the European Union, academia and civil society as a risk to Member State health budgets. It is therefore hardly surprising that, in recent years, competition authorities have resuscitated the excessive pricing prohibition contained in Article 102(a) TFEU. Focusing on this phenomenon, this piece highlights the diverse ways in which the United Brands test has been applied in pharmaceuticals by conducting a comparative study of the decisional practice of national competition authorities. Several observations and arguments are then derived therefrom, demonstrating that, while difficult (most notably in respect to patent-protected products), competition authorities and courts have established sophisticated ways of determining whether a pharmaceutical price is excessive in the sense of Article 102(a) TFEU. These findings should encourage hesitant competition authorities and private plaintiffs to at least carry out preliminary investigations when they suspect excessive pricing in pharmaceuticals is taking place.
Acceptable Risks in Europe’s Proposed AI Act: Reasonableness and Other Principles for Deciding How Much Risk Management Is Enough
Authors: Fraser Henry , Bello y Villarino José-Miguel 
Published: August 2023

AbstractThis paper critically evaluates the European Commission’s proposed AI Act’s approach to risk management and risk acceptability for high-risk artificial intelligence systems that pose risks to fundamental rights and safety. The Act aims to promote “trustworthy” AI with a proportionate regulatory burden. Its provisions on risk acceptability require residual risks from high-risk systems to be reduced or eliminated “as far as possible”, having regard for the “state of the art”. This criterion, especially if interpreted narrowly, is unworkable and promotes neither proportionate regulatory burden nor trustworthiness. By contrast, the Parliament’s most recent draft amendments to the risk management provisions introduce “reasonableness” and cost–benefit analyses and are more transparent regarding the value-laden and contextual nature of risk acceptability judgments. This paper argues that the Parliament’s approach is more workable and better balances the goals of proportionality and trustworthiness. It explains what reasonableness in risk acceptability judgments would entail, drawing on principles from negligence law and European medical devices regulation. It also contends that the approach to risk acceptability judgments needs a firm foundation of civic legitimacy, including detailed guidance or involvement from regulators and meaningful input from affected stakeholders.
Tame or wild Toeplitz shifts
Authors: FUHRMANN GABRIEL , KELLENDONK JOHANNES , YASSAWI REEM 
Published: August 2023

AbstractWe investigate tameness of Toeplitz shifts. By introducing the notion of extended Bratteli–Vershik diagrams, we show that such shifts with finite Toeplitz rank are tame if and only if there are at most countably many orbits of singular fibres over the maximal equicontinuous factor. The ideas are illustrated using the class of substitution shifts. A body of elaborate examples shows that the assumptions of our results cannot be relaxed.
COVID-19 fear and its associated correlates among type-2 diabetes patients in Bangladesh: A hospital-based study
Authors: Shuvo Suvasish Das , Hossen Md Toufik , Hossain Md Sakhawot , Khatun Asma , Mazumdar Sanaullah , Riazuddin Md , Roy Deepa 
Published: August 2023

Abstract
The outbreak of COVID-19 has caused widespread fear among people around the world, particularly those with underlying health conditions such as type-2 diabetes. This study aimed to investigate COVID-19 fear and its associated potential factors among type-2 diabetes patients in Bangladesh. A total of 1,036 type-2 diabetes patients residing in the Jashore district of Bangladesh were interviewed using the COVID-19 Fear Scale in Bengali language. A pre-validated questionnaire was used to collect data on sociodemographic, lifestyle-related characteristics, and COVID-19-related information. Logistic regression was performed to identify factors associated with perceived fear of COVID-19. The mean score of the COVID-19 fear was 18.1 ± 5.6. Approximately 45 and 39% were most afraid and uncomfortable thinking about COVID-19, respectively. Regression analysis revealed that gender, age, occupation, residence, physical activity, smoking, and dietary diversity score were associated with fear. Additionally, respondents who had limited self-care practice, unaffordable medicine, medicine shortages, a close friend or family member diagnosed with COVID-19, and financial problems during COVID-19 were significant predictors of COVID-19 fear. Healthcare providers should implement interventions, including appropriate education and counseling, to address the psychological impact of the COVID-19 pandemic on type-2 diabetes patients in Bangladesh.
Starch Analyses on Culinary Equipment from Chavin de Huantar
Authors: Mesía-Montenegro Christian , Weber Sadie L. 
Published: August 2023

AbstractExcavations at the Wacheqsa sector from Chavin de Huantar identified contexts from the Middle Formative (1100–900 BC) and Late Formative (900–550 BC) periods. We present results of starch analysis conducted in culinary equipment (ceramics) retrieved from domestic occupations and a large midden. Microbotanical analysis revealed a variety of plant food resources, such as maize, beans, olluco, and possibly chili peppers.
The blood of Christ: Sacrificial death or moral authority?
Authors: Wiese Tammy 
Published: August 2023

AbstractThe phrase blood of Christ has traditionally been interpreted as and used interchangeably with Christ's sacrificial death. As such, Jesus’ death is seen to be more crucial to salvation than his incarnation and resurrection. The blood of Christ language in the New Testament books of Hebrews and Romans echoes Old Testament cultic atonement language. Given recent and ample exegetical biblical scholarship that suggests blood of Christ language might refer to Christ's incarnational, resurrected life, we should explore the resulting soteriological implications. What salvific significance is there to the cross if Jesus Christ entered the Most Holy Place with his lifeblood flowing in his veins as David Moffitt asserts? I propose that the cross reveals God's legal and moral authority to forgive sin without minimising the law.
Seeking contexts that promote neurodiverse social success: Patterns of behavior during minimally-structured interaction settings in autistic and non-autistic youth
Authors: McNair Morgan L. , Keenan Elliot Gavin , Houck Abigail P. , Lerner Matthew D. 
Published: August 2023

AbstractWhile peer interaction differences are considered a central feature of autism, little is known regarding the nature of these interactions via directly-observed measurement of naturalistic (i.e., minimally-structured) groups of autistic and non-autistic adolescent peers. 148 autistic and non-autistic adolescents (111 male, Mage = 14.22, SDage = 1.90; MIQ = 103.22, SDIQ = 15.80) participated in a 50-minute, minimally-structured, naturalistic peer interaction paradigm with activities of varying social demands: an incidental social demand (eating in a room with peers), a physical social demand (playing a physically-interactive game), and a verbal social demand (playing a verbal game). While autistic youth exhibited fewer overall interaction behaviors than non-autistic youth, the two groups did not differ in amount of positive, negative, and low-level interaction behaviors. Within activities, autistic and non-autistic youth only differed in positive interaction behaviors during the context of a verbal social demand. Youth who displayed more positive interaction behaviors during this same activity had less autism spectrum disorder symptomatology, controlling for nested group effects and relevant covariates. These results point toward subtle differences in social demands across naturalistic settings that can either support or impede prosocial interaction for autistic youth, providing a guidepost for identifying settings that best promote social success for neurodiverse populations.