bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rationally designed graphene channels for real‐time sodium ion detection for electronic tongue
Authors: Lee Chung Won , Jun Sang Eon , Kim Seung Ju , Lee Tae Hyung , Lee Sol A. , Yang Jin Wook , Cho Jin Hyuk , Choi Shinyoung , Kim Cheol‐joo , Kim Soo Young , Jang Ho Won 
Published: May 2023

AbstractMonitoring taste‐inducing ions and molecules continuously in liquids or solutions is of great considerable matter for the realization of the electronic tongue (E‐tongue). Particularly from the five major tastes, the highly selective, sensitive detection of Na+ in real‐time is prioritized. Prioritization is due to the saltiness of food is the key ingredient in most meals. Nevertheless, existing Na+ detecting devices have relatively low performances of selectivity, sensitivity, and lack of on–off functions. Additionally, conventional devices significantly deteriorate in capacity due to repetitive usage or lifetime shortage by degradation of the sensing material. Herein, a graphene‐based channel was rationally designed by the facile decoration of Calix[4]arene and Nafion to address this issue. They act as a receptor and a molecular sieve, respectively, to enhance selectivity and sensitivity and elongate the life expectancy of the device. This device was merged with a microfluidic channel to control the injection and withdrawal of solutions to fulfill dynamic on–off functions. The fabricated device has highly selective, sensitive Na+ detection properties compared to other 10 molecule/ionic species. Dynamic on–off functions of the device were available, also possesses a long lifespan of at least 220 days. Additionally, it can precisely discriminate real beverages containing Na+, which can be observed by principal component analysis plot. These features offer the possibility of ascending to a platform for E‐tongues in near future.image
Bidirectional relationship between bullying victimization and functions of aggression in adolescents: The mediating effect of teacher justice
Authors: Ren Ping , Wang Yue , Liang Yiting , Li Simeng , Wang Quanquan 
Published: May 2023

AbstractIntroductionBullying victimization and aggression are frequent phenomena among adolescents and have been linked to various mental health problems. Although the correlation between bullying victimization and aggression is well‐documented, the direction between the two has been debated. Moreover, the underlying mechanism through which victimization influences aggression or vice versa has gained little attention. The current study used data across two‐time points to address this gap and explore the reciprocal relationships between victimization and aggression. The mediating role of teacher justice and related gender differences were also examined.MethodsA total of 2462 Chinese adolescents (50.9% boys; Mage  =  13.95 years, SD = 0.60) completed measures on two occasions in 1 year with 6‐month assessment intervals. Structural equation modeling was used to examine the longitudinal relations among the variables.ResultsResults found that bullying victimization significantly and positively predicted both reactive and proactive aggression over time among the total sample. Reactive aggression significantly positively predicted victimization, while proactive aggression negatively predicted victimization in boys. Furthermore, teacher justice mediated the relationships between victimization and both functions of aggression. Mediation was gender‐specific, with a significant mediating effect on girls.ConclusionsThe results reveal the violent cycle of bullying victimization and aggression and underscore the role of teacher justice in this process. These findings have important implications for targeted interventions.
Biofabrication of silver nanoparticles employing biomolecules of Paraclostridium benzoelyticum strain: Its characterization and their in‐vitro antibacterial, anti‐aging, anti‐cancer and other biomedical applications
Authors: Faisal Shah , Ullah Riaz , Alotaibi Amal , Zafar Sania , Rizwan Muhammad , Tariq Muhammad Hamza 
Published: May 2023

AbstractThe current study aims to utilize the bacteria Paraclostridium benzoelyticum strain 5610 to synthesize bio‐genic silver nanoparticles (AgNPs). Biogenic AgNPs were thoroughly examined using various characterization techniques such as UV‐spectroscopy, XRD, FTIR, SEM, and EDX. Synthesis of AgNPs was confirmed by UV–vis analysis resulting in absorption peak at 448.31 nm wavelength. The SEM analysis indicated the morphological characteristics and size of AgNPs which was 25.29 nm. The face centered cubic (FCC) crystallographic structure was confirmed by XRD. Furthermore, FTIR study affirmed the capping of AgNPs by different compounds found in biomass of the Paraclostridium benzoelyticum strain 5610. Later, EDX was used to determine the elemental composition with respective concentration and distribution. Additionally, in the current study the antibacterial, anti‐inflammatory, antioxidant, anti‐aging, and anti‐cancer ability of AgNPs was assessed. The antibacterial activity of AgNPs was tested against four distinct sinusitis pathogens: Haemophilus in‐fluenza, Streptococcus pyogenes, Moraxella catarrhalis and Streptococcus pneumonia. AgNPs shows significant inhibition zone against Streptococcus pyogenes 16.64 ± 0.35 followed by 14.32 ± 071 for Moraxella catarrhalis. Similarly, the antioxidant potential was found maximum (68.37 ± 0.55%) at 400 μg/mL and decrease (5.48 ± 0.65%) at 25 μg/mL, hence the significant antioxidant ability was observed. Furthermore, anti‐inflammatory activity of AgNPs shows the strongest inhibitory action (42.68 ± 0.62%) for 15‐LOX with lowest inhibition activity for COX‐2 (13.16 ± 0.46%). AgNPs have been shown to exhibit significant inhibitory actions against the enzyme elastases AGEs (66.25 ± 0.49%), which are followed by AGEs of visperlysine (63.27 ± 0.69%). Furthermore, the AgNPs show high toxicity against HepG2 cell line which shows 53.543% reduction in the cell viability after 24 h of treatment. The anti‐inflammatory activity demonstrated a potent inhibitory effect of the bio‐inspired AgNPs. Overall, the biogenic AgNPs have the ability to be served for the treatments of anti‐aging and also due to their anti‐cancer, antioxidant abilities NPs may be a useful therapy choice for a variety of disorders including cancer, bacterial infections and other inflammatory diseases. Moreover, further studies are required in the future to evaluate their in vivo biomedical applications.Highlights
Biogenic synthesis of AgNPs using Paraclostridium benzoelyticum Strain for the first time.
FTIR analysis confirmed capping of potent biomolecules which are of great use in applied field especially Nanomedicines.
Notable antimicrobial activity against sinusitis bacteria and cytotoxic potential of synthesized AgNPs on in vitro basis produce a new idea shifting us to treat cancerous cell lines.
Gallic and ferulic acids suppress proteolytic activities and volatile trimethylamine production in the food‐borne spoiler Rahnella aquatilis KM05
Authors: Myszka Kamila , Tomaś Natalia , Wolko Łukasz 
Published: May 2023

AbstractBACKGROUNDRahnella aquatilis is a recognised microbial threat that alters the sensory properties of seafood. The high frequency with which R. aquatilis is isolated from fish has prompted a search for alternative preservatives. In the present study, in vitro and fish‐based ecosystem (raw salmon‐based medium) approaches were used to validate the antimicrobial effects of gallic (GA) and ferulic (FA) acids against R. aquatilis KM05. The results were compared with data describing the response of KM05 to sodium benzoate. Bioinformatics data of the whole genome were used to analyse the potential for fish spoilage by KM05 in detail, and the results revealed the main physiological characteristics that underlie reduced seafood quality.RESULTSIn the KM05 genome, the most abundantly enriched Gene Ontology terms were ‘metabolic process’, ‘organic substance metabolic process’ and ‘cellular process’. Through an evaluation of the Pfam annotations, 15 annotations were found to be directly involved in the proteolytic activity of KM05. Peptidase_M20 was the most abundantly represented (abundance value of 14060). Proteins representing the CutC family (abundance value of 427) indicated the potential for KM05 degradation of trimethyl‐amine‐N‐oxide. Subinhibitory concentrations of GA and FA suppressed the proteolytic activities of KM05 both in vitro and in RS medium by an average of 33–45%. These results were confirmed by quantitative real‐time PCR experiments, which also showed that the expression levels of genes involved in proteolytic activities and volatile trimethylamine production were also decreased.CONCLUSIONPhenolic compounds can be used as potential food additives for preventing quality deterioration of fish products. © 2023 Society of Chemical Industry.
Comprehensive quality evaluation of plant‐based cheese analogues
Authors: Fan Mengmeng , Wei Teng , Lu Xiang , Liu Mengge , Huang Yingchao , Chen Fang , Luo Ting , Fan Yawei , Liu Rong , Deng Zeyuan , Li Jing 
Published: May 2023

AbstractBACKGROUNDIn recent years, there has been an increasing demand for plant‐based cheese analogues, however, the protein content of plant‐based cheeses currently on the market is generally low and cannot meet the nutritional needs of consumers.RESULTSBased on the ideal value similarity method (TOPSIS) analysis the best recipe for plant‐based cheese was 15% tapioca starch, 20% soy protein isolate, 7% gelatine as a quality enhancer and 15% coconut oil. The protein content of this plant‐based cheese was170.1 g kg−1, which was close to commercial dairy‐based cheese and significantly higher than commercial plant‐based cheese, The fat content was 114.7 g kg−1, lower than that of commercial dairy‐based cheese. The rheology properties show that the viscoelasticity of the plant‐based cheese is higher than that of dairy‐based cheese and commercial plant‐based. The microstructure results show that the type and content of protein has a significant impact on its microstructure. The Fourier‐transform infrared (FTIR) spectrum of the microstructure shows a characteristic value at 1700 cm−1, because the starch was heated and leached to form a complex with lauric acid under the action of hydrogen bond. It can be inferred that in the interaction between plant‐based cheese raw materials, fatty acids serve as a bridge between starch and protein.COUCLUSIONThis study described the formula of plant‐based cheese and the interaction mechanism between the ingredients, providing a basis for the development of subsequent plant‐based cheese related products. © 2023 Society of Chemical Industry.
Excellent response to adalimumab in a patient with Papillon–Lefèvre syndrome: A case report
Authors: Almukhadeb Eman , Alanazi Wael , Alshareef Rahaf , Altukhaim Feras , Albalbeesi Amal 
Published: May 2023

AbstractPapillon–Lefèvre syndrome (PLS) is a rare autosomal recessive disease that presents clinically with palmoplantar keratoderma and periodontitis and results in early‐onset dental loss. PLS management is difficult. We report a 30‐year‐old female with PLS who had unfavourable response to topical keratolytic creams, oral isotretinoin and narrow‐band ultraviolet‐B (NB‐UVB) phototherapy but showed significant clinical improvement to adalimumab.
Long‐term secukinumab efficacy and safety in bio‐naïve patients with moderate‐to‐severe cutaneous psoriasis: A real‐world retrospective noninterventional multicentric experience (128 patients)
Authors: Melgosa Ramos Francisco Javier , Mateu Puchades Almudena , Guillén Climent Santiago , Galarreta Pascual Marta , Saéz Belló Marina , Martínez Ferrer María Angels , Alberola Fernando Toledo , Magdaleno Tapial Jorge , Sánchez Carazo Jose Luís , Díaz Javier Matáix , Schneller‐Pavelescu Apetrei Luca , García Fernández Laura , González Villanueva Iris , Belinchón Romero Isabel , Martín Jiménez Sergio , Santos Alarcón Sergio 
Published: May 2023

AbstractBackgroundThere is limited evidence over the real‐life secukinumab survival in psoriatic patients, especially in the long‐term bio‐naïve subjects, and to date biological treatments have been assessed in patients with a chronic and recalcitrant psoriasis. It has been hypothesised that early intensive treatment with biological therapies could decrease pathogenic tissue resident memory (TRm) cells migration and potentially modify the natural course of psoriasis and related comorbidities.ObjectivesTo analyze long‐term secukinumab efficacy, safety and survival, and its predictive factors for psoriasis treatment determining also whether early intervention may result in better outcomes for patients.MethodsBio‐naïve psoriatic patients under treatment with secukinumab (n = 128 patients) in a daily practice setting were analyzed in a retrospective multicentric study and followed up to 8 years. Drug survival rate, efficacy, posology and safety were reported.ResultsThe overall secukinumab survival was 81.9% for an average treatment exposure of 147.9 weeks. The approved posology was the most commonly prescribed regimen (78.7%), and 17.7% could be optimized. An absolut‐PASI ≤3 was reached by 86.6%, 82.6% and 91.7% at the weeks 48,156 and 264, respectively. The incidence of arthritis or psoriasis related comorbidities was low. The response was not influenced by weight, age (>65), gender or the presence of arthritis. No severe adverse events were reported.ConclusionsIn our bio‐naïve series, the high efficacy and long‐term survival rates observed and the low prevalence of arthritis and comorbidities might suggest that early intervention could contribute to modify the course of the disease, but further studies are needed.
RAS‐targeted cancer therapy: Advances in drugging specific mutations
Authors: Liu Cen , Ye Danyang , Yang Hongliu , Chen Xu , Su Zhijun , Li Xia , Ding Mei , Liu Yonggang 
Published: May 2023

AbstractRat sarcoma (RAS), as a frequently mutated oncogene, has been studied as an attractive target for treating RAS‐driven cancers for over four decades. However, it is until the recent success of kirsten‐RAS (KRAS)G12C inhibitor that RAS gets rid of the title “undruggable”. It is worth noting that the therapeutic effect of KRASG12C inhibitors on different RAS allelic mutations or even different cancers with KRASG12C varies significantly. Thus, deep understanding of the characteristics of each allelic RAS mutation will be a prerequisite for developing new RAS inhibitors. In this review, the structural and biochemical features of different RAS mutations are summarized and compared. Besides, the pathological characteristics and treatment responses of different cancers carrying RAS mutations are listed based on clinical reports. In addition, the development of RAS inhibitors, either direct or indirect, that target the downstream components in RAS pathway is summarized as well. Hopefully, this review will broaden our knowledge on RAS‐targeting strategies and trigger more intensive studies on exploiting new RAS allele‐specific inhibitors.
Joint radial trajectory correction for accelerated T2* mapping on an MR‐Linac
Authors: Bano Wajiha , Holmes Will , Goodburn Rosie , Golbabaee Mohammad , Gupta Amit , Withey Sam , Tree Alison , Oelfke Uwe , Wetscherek Andreas 
Published: May 2023

AbstractBackgroundT2* mapping can characterize tumor hypoxia, which may be associated with resistance to therapy. Acquiring T2* maps during MR‐guided radiotherapy could inform treatment adaptation by, for example, escalating the dose to resistant sub‐volumes.PurposeThe purpose of this work is to demonstrate the feasibility of the accelerated T2* mapping technique using model‐based image reconstruction with integrated trajectory auto‐correction (TrACR) for MR‐guided radiotherapy on an MR‐Linear accelerator (MR‐Linac).Materials and methodsThe proposed method was validated in a numerical phantom, where two T2* mapping approaches (sequential and joint) were compared for different noise levels (0,0.1,0.5,1) and gradient delays ([1, ‐1] and [1, ‐2] in units of dwell time for x‐ and y‐axis, respectively). Fully sampled k‐space was retrospectively undersampled using two different undersampling patterns. Root mean square errors (RMSEs) were calculated between reconstructed T2* maps and ground truth. In vivo data was acquired twice weekly in one prostate and one head and neck cancer patient undergoing treatment on a 1.5 T MR‐Linac. Data were retrospectively undersampled and T2* maps reconstructed, with and without trajectory corrections were compared.ResultsNumerical simulations demonstrated that, for all noise levels, T2* maps reconstructed with a joint approach demonstrated less error compared to an uncorrected and sequential approach. For a noise level of 0.1, uniform undersampling and gradient delay [1, ‐1] (in units of dwell time for x‐ and y‐axis, respectively), RMSEs for sequential and joint approaches were 13.01 and 9.32 ms, respectively, which reduced to 10.92 and 5.89 ms for a gradient delay of [1, 2]. Similarly, for alternate undersampling and gradient delay [1, ‐1], RMSEs for sequential and joint approaches were 9.80 and 8.90 ms, respectively, which reduced to 9.10 and 5.40 ms for gradient delay [1, 2]. For in vivo data, T2* maps reconstructed with our proposed approach resulted in less artifacts and improved visual appearance compared to the uncorrected approach. For both prostate and head and neck cancer patients, T2* maps reconstructed from different treatment fractions showed changes within the planning target volume (PTV).ConclusionUsing the proposed approach, a retrospective data‐driven gradient delay correction can be performed, which is particularly relevant for hybrid devices, where full information on the machine configuration is not available for image reconstruction. T2* maps were acquired in under 5 min and can be integrated into MR‐guided radiotherapy treatment workflows, which minimizes patient burden and leaves time for additional imaging for online adaptive radiotherapy on an MR‐Linac.
Robust online detection in serially correlated directed network
Authors: Yu Miaomiao , Zhou Yuhao , Tsung Fugee 
Published: May 2023

AbstractAs the complexity of production processes increases, the diversity of data types drives the development of network monitoring technology. This paper mainly focuses on an online algorithm to detect serially correlated directed networks robustly and sensitively. First, we consider a transition probability matrix to resolve the double correlation of primary data. Further, since the sum of each row of the transition probability matrix is one, it standardizes the data, facilitating subsequent modeling. Then we extend the spring length based method to the multivariate case and propose an adaptive cumulative sum (CUSUM) control chart on the strength of a weighted statistic to monitor directed networks. This novel approach assumes only that the process observation is associated with nearby points without any parametric time series model, which is in line with reality. Simulation results and a real example from metro transportation demonstrate the superiority of our design.
Exploring the impact of pediatric short bowel syndrome on parent well‐being using a disease‐specific pilot survey
Authors: Neumann Marie L. , Allen Jessica Y. , Ladner Amy , Kakani Swapna , Weaver Meaghann S. , Mercer David F. 
Published: May 2023

AbstractBackgroundChildren with short bowel syndrome (SBS) have complex care needs, most of which are met in the home by family caregivers who may experience a range of stressors unique to this experience. Prior research suggests that parents of children with SBS have poorer health‐related quality of life than peers parenting children without health needs, but the mechanisms shaping parent outcomes are understudied.MethodsA pilot survey was developed using a community‐driven research design to measure the impact of disease‐specific items on parent‐perceived well‐being. The cross‐sectional survey, which included both closed‐ended and open‐ended items, was distributed to a convenience sample of parents of children with SBS. Quantitative and qualitative data were integrated for a mixed‐methods analysis of how individual items impacted parent well‐being.ResultsTwenty parents completed the survey. Sleep interruptions, lack of support and resources, and psychological stressors and their mental health implications were more frequently reported as stressors than logistics related to caregiving (e.g., managing therapies and preparing specialized meals).ConclusionThe impact of a child's SBS on parent well‐being may stem mainly from three interconnected domains: poor sleep and its consequences, lack of access to support and resources, and a range of psychological stressors that affect parent mental health. Understanding the mechanisms through which SBS shapes parent well‐being is a necessary first step for developing targeted interventions to support parents and provide family‐centered care.
Exposure to a more unhealthy diet impacts sleep microstructure during normal sleep and recovery sleep: A randomized trial
Authors: Brandão Luiz Eduardo Mateus , Popa Alexandru , Cedernaes Erasmus , Cedernaes Christopher , Lampola Lauri , Cedernaes Jonathan 
Published: May 2023

AbstractObjectiveAlthough intake of specific macronutrients has been associated with sleep parameters, interventional evidence is lacking. Therefore, this randomized trial was conducted to examine how a more unhealthy high‐fat/high‐sugar (HFHS) diet impacts sleep in humans.MethodsIn a crossover study, 15 healthy young men consumed two isocaloric diets in random order for a week: an HFHS and a low‐fat/low‐sugar diet. Following each diet, in‐lab sleep was recorded using polysomnography during a full night of sleep and during recovery sleep after extended wakefulness. Sleep duration, macrostructure, and microstructure (oscillatory pattern and slow waves) were investigated using machine learning‐based algorithms.ResultsSleep duration did not differ across the diets based on actigraphy and the in‐lab polysomnography. Sleep macrostructure was similar after 1 week on each diet. Compared with the low‐fat/low‐sugar diet, consumption of the HFHS diet resulted in reduced delta power, delta to beta ratio, and slow wave amplitude but increased alpha and theta power during deep sleep. During recovery sleep, similar sleep oscillatory changes were observed.ConclusionsShort‐term consumption of a more unhealthy diet alters sleep oscillatory features that regulate the restorative properties of sleep. Whether such changes can mediate adverse health outcomes associated with consumption of an unhealthier diet warrants investigation.