bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaginismus: An Approach from biology to psychological aspect
Authors: Prananjaya Bintang Arroyantri , Aini Syarifah , Loo Jiann Lin , Ikhsan Diyaz Syauki , Suryani Puji Rizki , Rashid Alessandro Syafei 
Published: May 2023

Background: The prevalence of vaginismus ranges from 1-6%, and the ratio becomes 5%-17% in clinical setting, although it varies widely worldwide. The main cause of vaginismus is not known, but is often considered multifactorial. This paper aims to describe the factors that contribute to vaginismus. Case: A 26 years old, married woman, health practitioner presented with the complaint of not being able to have sexual intercourse. About 1 month ago, since marriage, the patient was unable to have sexual intercourse with her husband. The patient feels guilty and anxious because of the inability to please her husband. The patient's father was very dominant and was a "religious" type of parent who always gave advice with religious aspects regarding all matters. The patient's mother was a nervous person and always said that what the father said was a law that had to be obeyed. Likewise, talk about sex is a taboo topic of discussion and is considered embarrassing. Discussion: Many factors need to be explored related vaginismus. In the case, the biological aspect can be ruled out because the patient has consulted with the ob-gyn doctor. from the psychological aspect; perceptions, attitudes and attitudes towards sex and the values ​​held by parents contribute to vaginismus in this patient. Conclusion: a therapeutic approach which focuses on all aspects promises quite good therapeutic outcomes.
Rapeseed Meal Waste Biomass as Single-Cell Protein Substrate for Nutritionally-Enhanced Feed Component
Authors: Dygas Dawid , Liszkowska Wiktoria , Steglińska Aleksandra , Sulyok Michael , Kręgiel Dorota , Berłowska Joanna 
Published: May 2023

Rapeseed meal (RM) is an important agroindustrial by-product produced in large quantities by oil extraction from seeds. However, the efficient utilization of RM as animal feed is limited by its low metabolizable energy, poor palatability, and high levels of fiber and anti-nutritional components. Here, we investigate the potential of enriching RM with single-cell protein by fermentation with conventional and unconventional yeasts, to make a nutritionally improved feed component. The process of simultaneous saccharification and fermentation improved the parameters of the waste biomass, especially the protein content, the amount of crude fiber, and the degree of biotransformation of isoflavone compounds present in the waste material. Fermentation yielded the highest protein gain for the Saccharomyces cerevisiae Ethanol Red strain (ΔN=2.38%) at a biomass load of 12.5 g and for Scheffersomyces stipitis (ΔN=2.34%) at an enzyme dose of 0.125ml/10g DM. Crude fiber content (CF) was reduced by 2.55–7.18%. The SSF process resulted in the conversion of isoflavones to forms with fewer adverse effects and lower estrogenic activity.
Multiomics Data Analysis Identified CpG Sites That Mediate the Impact of Smoking on Cardiometabolic Traits
Authors: Nikpay Majid 
Published: May 2023

Understanding epigenome paths through which smoking contributes to cardiometabolic traits is important for downstream applications. In this study, I used a SNP-based analytical pipeline to integrate several publicly available datasets and identify CpG sites that mediate the impact of smoking on cardiometabolic traits. After applying stringent statistical criteria, 11 CpG sites were detected that showed significant association (P&lt;5e-8) with cardiometabolic traits at both discovery and replication stage. By integrating eQTL data, I identified genes behind a number of these associations. cg05228408 was hypomethylated in smokers and contributed to higher blood pressure by lowering the expression of CLCN6 gene. cg08639339 was hypermethylated in smokers and lowered metabolic rate by increasing the expression of RAB29; furthermore, I noted TMEM120A mediated the impact of smoking-cg17325771 on LDL, and LTBP3 mediated the smoking-cg07029024 effect on heart rate.
This study provides a list of CpG sites that mediates the impact of smoking on cardiometabolic traits and a framework to investigate epigenome path through which a lifestyle habit modifies disease risks.
PERANAN POLRI DALAM PENANGGULANGAN TINDAK PIDANA SIBER OLEH DESK COLLECTOR PINJAMAN ONLINE
Authors: Nurwahridya Meingga Mahening , Hartiwiningsih ' 
Published: May 2023

<p>Abstrak<br />Tujuan penelitian ini mendeskripsikan dan mengkaji permasalahan, mengapa Polri dalam melaksanakan tugasnya untuk menanggulangi tindak pidana dalam penagihan pinjaman online oleh desk collector belum optimal. Penelitian ini adalah penelitian hukum empiris bersifat deskriptif. Jenis data sekunder meliputi bahan hukum primer dan bahan hukum sekunder. Teknik pengumpulan data yang digunakan adalah wawancara dan studi kepustakaan, selanjutnya teknis analisis yang digunakan adalah metode kualitatif. Hasil penelitian menunjukkan bahwa Polri dalam melaksanakan tugasnya untuk menanggulangi tindak pidana dalam penagihan pinjaman online (cyber crime) oleh desk collector belum optimal dikarenakan adanya hambatan-hambatan, baik hambatan dari undang-undang perbankan, tidak adanya alat untuk membuktikan tindak pidana ITE, kesulitan mendatangkan saksi dan ahli, dan minimnya SDM kepolisian yang paham pembuktian ITE dan masyarakat yang belum bisa kooperatif.<br />Kata Kunci : Hambatan kepolisian; penanggulangan kejahatan; tindak pidana ITE; Pinjaman Online.</p><p>Abstract<br />This study describes and examines why the Indonesian Police Department is not optimal while there’s on duty for prevention Desk Collector crime. This research is empiric legal research which is descriptive. In nature the data used in this research is secondary data including primary legal materials and secondary. Data collection techniques used is interview and library study. Technical analysis is qualitative method. The results shows that Indonesian Police Department is not optimal while there’s on duty for preventing Desk Collector crime (cyber crime) to online lending costumer is because there’s many obstacles, such as banking regulation, there is no tool for cyber crime evidence, difficulty in bringing witness and expert witness, lack of personnel Indonesian police department who understand the cyber crime evidence, and many people doesn’t cooperative with the police. <br />Keywords : Police obstacles; crime prevention; cyber crime; online lending.</p>
Trends in Female Authorship in Orthopaedic Literature from 2002 to 2021
Authors: Ghattas Yasmine S. , Kyin Cynthia , Grise Alison , Glasser Jillian , Johnson Taylor , Druskovich Katherine , Cannada Lisa K. , Service Benjamin C. 
Published: May 2023

Background:
Significant gender disparity exists in orthopaedic surgery. While women have increasingly entered the field, we are short of the critical mass needed to drive change, including in authorship. This study aimed to characterize trends in authorship in peer-reviewed orthopaedic journals in the context of gender.

Methods:
This is a cross-sectional bibliometric study of orthopaedic journals in the United States. Articles that were indexed in the orthopaedic category of the Clarivate Journal Citation Report (JCR) and the Science Citation Index Expanded (SCIE) were analyzed (n = 82). Journals not originating from the U.S. (n = 43) or not considered primarily orthopaedic journals (n = 13) were excluded. The 2020 impact factors (IFs) of the remaining 26 journals were recorded. The articles underwent automated data collection from PubMed for January 2002 to December 2021 using R software to collect the title, the journal, the publication year, the first and senior author names, and the country of origin. Gender was determined by Gender API (https://gender-api.com). Names with <90% accuracy were excluded.

Results:
Overall, 168,451 names were studied, with 85,845 and 82,606 first and senior authors, respectively. Of the first and senior authors, 13.6% and 9.9%, respectively, were female. The proportion of female first authors was significantly greater than the proportion of female senior authors. The average IF was significantly higher for male authors compared with female authors (p < 0.005). Articles with female first authors were significantly more likely to have a female senior author. Orthopaedic subspecialty journals had a smaller proportion of manuscripts authored by female first and senior authors than general journals (p < 0.0001). There were 4,451 articles written by a single author, of which 92% (4,093) were written by a man and 8% (358) were written by a woman. Over the 20-year study period, the proportion of female first authorship exhibited a significant positive trend; however, there was a non-significant increase in female senior authorship.

Conclusions:
Female representation in orthopaedics has been growing over the past decade. Increasing publication rates of female authors reveal steps toward positive gender equity in the field and present an opportunity for female leadership visibility, illustrating the capabilities of women in orthopaedics and encouraging more women to join the field.
Arthroscopic Pectoralis Minor Release After Reverse Shoulder Arthroplasty
Authors: Stern Elinor , Karzon Anthony L. , Hussain Zaamin B. , Khawaja Sameer R. , Cooke Hayden L. , Pirkle Sarah , Bowers Robert L. , Gottschalk Michael B. , Wagner Eric R. 
Published: May 2023

Case:
A 74-year-old male patient presenting with chronic radiating shoulder pain, paresthesias, and weakness had previously undergone reverse shoulder arthroplasty and anterior cervical discectomy and fusion for an irreparable cuff tear and cervical radiculopathy, respectively. After being diagnosed with neurogenic thoracic outlet syndrome and undergoing physiotherapy, the patient's recalcitrant condition was surgically managed with arthroscopic pectoralis minor tenotomy, suprascapular nerve release, and brachial plexus neurolysis.

Conclusion:
This ultimately led to complete pain relief and improved function. By sharing this case, we aim to shed light on this overlooked pathology and help prevent unnecessary procedures for others suffering from similar conditions.
Numerical Study on Simultaneous Propagation of Multiple Fractures: A Method to Design Nonuniform Perforation and In-Stage Diversion
Authors: Yunpeng Wang , Tiankui Guo , Ming Chen , Zhanqing Qu , Zunpeng Hu , Jinhao Cao , Dingwei Weng 
Published: May 2023

Summary
The uneven propagation of multifractures is a key factor restricting production growth due to stress shadow and heterogeneity. To date, limited-entry fracturing techniques, nonuniform perforation, and in-stage diversion have been commonly used to promote even multifracture growth. In this study, a fully coupled multiple pseudo-3D (P3D) fracture simulator has been developed to examine the competitive propagation of multifractures during multicluster fracturing in a horizontal well. The present model considers stress interaction among multiple fractures, perforation erosion, fluid distribution among clusters, and in-stage diversion. The results of the model are validated against the reference data. Using the model, a series of numerical simulations are performed to investigate multifracture propagation with nonuniform perforation and in-stage diversion fracturing. We estimate the value of stress interaction for different fractures and time based on the approximate solution of Perkins-Kern-Nordgren (PKN) fracture in the viscosity-dominated regime and improve the dimensionless parameter that characterizes the competition between stress interaction and perforation friction. The fluid distributes evenly when the dimensionless parameter is less than unity (perforation friction is larger than stress interference). Based on this dimensionless parameter, a method to design nonuniform perforation and in-stage diversion is proposed. Results show that in the case of homogeneous in-stage stress, the perforation parameters should be selected under the condition that the dimensionless parameter is less than unity. In the case of heterogeneous in-stage stress and based on the perforation parameters selected under homogeneous stress conditions, the perforation holes in the high-stress cluster should be increased, making the reduction of perforation friction equal to the value of the in-stage stress heterogeneity. The stress heterogeneity can be balanced by decreasing the perforation friction of the high-stress clusters. In this way, nonuniform perforation under heterogeneous in-stage stress conditions can be designed quantitatively without numerical simulation. For in-stage diversion treatment, a method to design the number of ball sealers is proposed based on the results of nonuniform perforation, and only several or even zero groups of simulation are necessary to find the optimal number of ball sealers. A series of numerical simulations shows that the proposed design method is reliable and achieves a satisfactory result in an actual field case. The results can be helpful for nonuniform perforation and in-stage diversion design for multicluster fracturing in a horizontal well.
Effectiveness of a Heart Disease Blended Learning Program in Future Physiotherapy Professionals: A Prospective Study
Authors: Marques-Sule Elena , Hernández-Guillén David , Cezón-Serrano Natalia , Arjona-Tinaut Laura , Sillero-Sillero Amalia , Sánchez-González Juan Luis , Cobos-Rincón Ana , Juárez-Vela Raúl , Tejada-Garrido Clara Isabel , Muñoz-Gómez Elena 
Published: May 2023

Abstract
Background. Blended learning is a novel learning methodology.
Purpose. To determine the effectiveness of a heart disease blended learning program in future physiotherapy professionals.
Methods. 124 participants (average age 21.20 (SD=4.67) years, 58.87% female) performed an 8-week heart disease blended learning program that included face-to-face classes and online resources. Knowledge was assessed at baseline, at 4, 8, 12 and 20 weeks. Motivation and engagement were assessed at 4 and 8 weeks. Design of the instructions and learning behaviors were measured at 8 weeks.
Results. Knowledge significantly increased mid-program (p=0.02), at the end of the program (p<0.001), at 12 weeks (p<0.001) and 20 weeks (p=0.001). After the intervention, a high intrinsic motivation was shown (5.60 (SD=0.80)) over 7), whilst extrinsic motivation scored 4.24 (SD=0.97) over 7. Finally, engagement (3.98 (SD=0.52) over 5), design of the instructions (4.15 (SD=0.62) over 5) and learning behaviors (70.51 (SD=36.08) downloads, 28.97 (SD=16.09) topics visited, and online questionnaires scored 7.67 (SD=1.60) over 10) reported adequate scores.
Conclusion. This program seems to be an appropriate methodology in future physiotherapy professionals, since it improved knowledge and participants exhibited a high motivation and an adequate engagement, design of the program instructions and learning behaviors.
Use of flower strips to attract pollinator insects and natural enemies in tomato crops
Authors: Ladeia Sarah Cavalari , Santos Milaine Fernandes , Júnior Ernandes Sobreira Oliveira , Santos Alexandre dos , Galbiati Carla 
Published: May 2023

Abstract

The goal of this research was to analyze the effect of flower strips and the proximity of corn fields on the environmental services of regulation by insects (pollination and biological control) in tomato crops (Solanum lycopersicum). The study was conducted using commercial tomatoes (6.200 m²) in the Brazilian Cerrado. The experimental outline was completely randomized with 15 plots of 5 x 4 meters, constructed with 16 tomato plants, in two treatments: 1) tomato plants without attractive flower strips (control) and 2) tomato plants with attractive flower strips of cilantro and sorghum. The sampling of pollinator insects and natural enemies was performed using trap-type bee bowls and active collection. Data were analyzed by generalized linear models (GLM) to compare insect diversity and abundance between treatments. As a result, the richness (p = 0.040) and abundance (p = 0.030) of pollinating insects were significantly higher in tomatoes with sorghum flowers than in the control. The effect of mixing strips of intercropped flowers (cilantro and sorghum) increased the abundance (p = 0.007) and richness (p = 0.005) of the total natural enemies and pollinators in richness (p = 0.030) and abundance (p = 0.020) in the tomato plants with the flower strips compared to the tomato plants without the strips. Our results clearly show that the use of attractive flower strips of the mix of cilantro and sorghum in interleaved periods with tomato plants contributes to the permanence of the services provided by insects to the crop field.
Independent transcriptional patterns reveal biological processes associated with disease-free survival in early colorectal cancer
Authors: Fehrmann Rudolf , Knapen Daan , Lopez Sara Hone , de Groot Derk Jan , de Haan Jacco , de Vries Elisabeth , Dienstmann Rodgrigo , de Jong Steven , Bhattacharya Arkajyoti 
Published: May 2023

Abstract

Bulk transcriptional profiles of early colorectal cancer (CRC) can fail to detect biological processes associated with disease-free survival (DFS) if the transcriptional patterns are subtle and/or obscured by other processes’ patterns. Consensus independent component analysis (c-ICA) can dissect such transcriptomes into statistically independent transcriptional components (TCs), capturing both pronounced and subtle biological processes. Here, we applied c-ICA to 4,268 transcriptomes and identified 191 TCs, 43 of which were associated with DFS, revealing transcriptional diversity among DFS-associated biological processes. A prominent example is the epithelial-mesenchymal transition (EMT), for which we identified an association with eight independent DFS-associated TCs, each with coordinated upregulation or downregulation of various sets of genes. This finding indicates that early CRC may have eight distinct routes to achieve EMT, each requiring a specific peri-operative treatment strategy. Finally, we stratified patients into DFS patient subgroups with distinct transcriptional patterns associated with stage 2 and stage 3 CRC.
ISG20L2: an RNA nuclease regulating T cell activation
Authors: Rodríguez-Galán Ana , Dosil Sara , Hrčková Anna ,   Lola Fernández-Messina1, Feketová Zuzana , Pokorná Julie , Fernández-Delgado Irene , Camafeita Emilio , Gómez Manuel , Huesca Marta Ramírez- , Gutiérrez-Vázquez Cristina , Sánchez-Cabo Fátima , Vázquez Jesús , Vaňáčová Štěpánka , Sanchez-Madrid Francisco 
Published: May 2023

Abstract

ISG20L2, a 3’ to 5’ exoribonuclease previously associated with ribosome biogenesis, is identified here in activated T cells as an enzyme with a preferential affinity for uridylated miRNA substrates. This enzyme is upregulated in T lymphocytes upon TCR and IFN type I stimulation, and appears to be involved in regulating T cell function. ISG20L2 silencing leads to an increased basal expression of CD69, and induces greater IL2 secretion. However, ISG20L2 absence impairs CD25 upregulation, CD3 synaptic accumulation and MTOC translocation towards the antigen-presenting cell during immune synapsis. Remarkably, ISG20L2 controls the expression of immunoregulatory molecules, such as AHR, NKG2D, CTLA-4, CD137, TIM-3, PD-L1 or PD-1, which show increased levels in ISG20L2 knockout T cells. The dysregulation observed in these key molecules for T cell responses support a role for this exonuclease as a novel RNA-based regulator of T cell function.
Attitudes to alcohol and consumption of alcohol in UK residents aged 50 and above
Authors: Webster Bobbie , Thelu Madeleine , Orrell Martin , Jones Katy A 
Published: May 2023

Abstract
Background Many people aged 50 and over are increasing their alcohol consumption. Excessive alcohol use, combined with aging, can have a detrimental effect on health and wellbeing. This study aimed to measure alcohol consumption and explore attitudes to alcohol in this age group. Attitudes to ageing and demographic factors were explored as predictors.Methods Cross-sectional survey data were gathered from 2,675 UK residents aged 50 or over (mean age = 66) through the Join Dementia Research platform. Demographic data, alcohol consumption (AUDIT-C), attitudes to alcohol and ageing were collected. Two-tailed bivariate Spearmen correlation was used, and two linear and hierarchical regression models were conducted.Results A total of 34.8% (n = 931) of participants were classed as ‘at-risk’ drinkers. Majority (n = 1,671 63.5%) stated they knew the UK Government guidelines for alcohol intake, and most agreed drinking over this limit would affect their physical (n = 2,177 82.7%), and mental health (n = 1,961 74.5%). Younger people, those with higher levels of education, in better overall health had higher AUDIT-C scores, with age the only significant block in the hierarchical regression model. Less risky attitudes to alcohol were predicted by more positive attitudes to ageing and better self-reported health in the regression model.Conclusions There is a need for more information about alcohol limits and health effects in this age group. Variables shown to influence alcohol consumption and attitudes to alcohol could be used when designing targeted information to reduce alcohol consumption. Future research should identify other risk factors in this age group.
Laser mode speckle ghost imaging of underwater environments
Authors: Feng Guoying , Yang Mochou , Wu Yi , Wang Peng 
Published: May 2023

Abstract
Absorption, scattering, noise, and low-sensitivity detector lead to poor quality in conventional underwater imaging. In response, Ghost imaging (GI) has emerged as an effective anti-interference underwater imaging method based on the relationship between illumination speckle patterns and a non-spatial-resolution detector. Conventional speckle patterns are distributed based on mathematical models such as the random, Hadamard, or Walsh models. In this study, we apply novel speckle patterns based on a physical model of M2 ordered laser modes to GI. The laser mode speckle pattern GI (LMS-GI) system achieves perfect imaging quality at a sampling rate of 5% or less; good imaging quality persists even below 0.64%. Despite relative random noise of 1.0%~ 5.0%, it outperforms the other GIs. Furthermore, at a low sampling rate of 2.48%, LMS-GI is effective not only in inclement weather, but also in complex liquid environments such as turbid liquids and biological tissue fluids.