bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die Pläne der EU-Kommission für einen CO₂-Grenzausgleich
Authors: Söllner Fritz 
Published: February 2023

Zusammenfassung
Das CO₂-Grenzausgleichssystem der EU kann die Verlagerung der Produktion beziehungsweise von Emissionen in Drittländer nur zum Teil verhindern. Es wird sehr hohe Kosten verursachen, nicht zu einer kosteneffizienten Emissionsreduktion beitragen und kaum Anreize für Drittländer schaffen, ihre Emissionen zu reduzieren. Das System ist nicht WTO-konform und wird deshalb Anlass zu handelspolitischen Streitigkeiten und Konflikten geben, unter denen vor allem Deutschland mit seinen hohen Exportüberschüssen zu leiden haben wird. Es spricht vieles dafür, das vorgeschlagene System nicht zu realisieren und die Wettbewerbsnachteile europäischer Unternehmen weiter durch die teilweise gratis erfolgende Zuteilung von ETS-Zertifikaten auszugleichen.
“She of Uriah” (Matthew 1,6): An Evocative and Multivalent Genealogical Annotation
Authors: Aernie Jeffrey W. 
Published: February 2023

Abstract
This article examines an aspect of Matthew’s unique reference to Bathsheba that is often neglected in discussions of the women in the genealogy, namely the position of this genealogical annotation within the three-part generational structure of Matthew’s genealogy (Matt 1,17). It will be argued that consideration of the structural position of this annotation points to its intentional multivalence. Matthew refers to Bathsheba as “she of Uriah” to create conceptual and structural connections with multiple components of Jesus’s genealogy. To develop this thesis, the article discusses the integrated narrative function of Matthew’s genealogical annotations, examines the distinct structural position of “she of Uriah” within the genealogy, and demonstrates how its multivalence sharpens contemporary readings of the women in Matthew’s genealogy.
Mit realistischem Blick – Lukanische Perspektiven auf Geld
Authors: Wojtkowiak Heiko 
Published: February 2023

Abstract
The widespread tendency to see money as primarily or even exclusively negative in Luke deserves critical scrutiny. On the contrary, it can be shown that Luke views money with a clear-eyed realism, including a broad acceptance of the role that money plays in everyday human life. On the parabolic level, the importance of money is recognized even beyond its necessity for ensuring immediate survival, and monetary institutions such as earning interest or money changers are used as analogies. Even in texts with critical perspectives on money, no purely negative assessment is given. The significance of Luke’s nuanced perspective on money is shown by the light it sheds on our understanding of the parable of the Dishonest Manager.
τὰ στοιχεῖα τοῦ κόσμου Again: Interpreting Cosmos in Gal 4,3 and 9 as Prepuce (or Foreskin)
Authors: Barrier Jeremy W. 
Published: February 2023

Abstract
The meaning of the phrase τὰ στοιχεῖα τοῦ κόσμου in Gal 4,3 has been debated for nearly two millenia. A new understanding of Paul’s utilization of the term τοῦ κόσμου is considered in this essay. In addition to ὁ κόσμος meaning “the world” in Gal 4,3, an argument can be made that ὁ κόσμος is a reference to the “adornment” of the penis (i. e., the foreskin). The lexicographical evidence supports this reading. In other words, the reference to κόσμος in Gal 4,3 is an additional critique of the Galatians’ decision to circumcise the male members of their communities.
Ein Geist der Besonnenheit? Σωφρονισμός in 2Tim 1,7
Authors: Krauter Stefan 
Published: February 2023

Abstract
Almost all current translations of 2Tim 1:7 understand σωφρονισμός in this verse as a synonym of σωφροσύνη. So do authoritative recent commentaries and dictionaries. This paper demonstrates that word formation makes this unlikely and that σωφρονισμός is never used synonymously with σωφροσύνη in ancient Greek literature. It is shown that the usual meaning of “making someone σώφρων” is possible and appropriate for 2Tim 1:7. A survey of ancient translations and interpretations of the verse by ancient Christian writers shows that most of them also consider this meaning possible and obvious.
Frühaufklärung produktionskritischer Diskontinuitäten
Authors: Dobler Richard , Frech Nicolas , Reinhart Gunther 
Published: February 2023

Abstract
Um Industriebetrieben die Nutzung von Chancen und die Vermeidung von Risiken durch Diskontinuitäten zu ermöglichen, ist ein geeigneter Frühaufklärungsansatz notwendig. Obwohl Frühaufklärungssysteme bereits entwickelt wurden, gilt es weiterhin, eine Methodik zu erforschen, die sich insbesondere mit produktionskritischen Diskontinuitäten beschäftigt. Daher wird im Rahmen dieses Beitrags eine solche Vorgehensweise vorgestellt.
KI-Kanban-Behälter
Authors: Rokoss Alexander , Popkes Lennart , Kramer Kathrin , Green Thorben , Schmidt Matthias 
Published: February 2023

Abstract
Mit dem Kanban-Verfahren gesteuerte Produktionssysteme nutzen heute elektronische Unterstützung zur Verfolgung einzelner Behälter, um datenbasiert Logistikprozesse zu verbessern. Dieser Beitrag stellt eine alternative technische Auslegung vor. Es finden mit Sensoren ausgestattete Behälter Verwendung, welche über einen KI-fähigen Mikrocontroller ihren Standort im Produktionssystem dezentral ermitteln, um ohne feste Erfassungspunkte eine permanente Nachverfolgbarkeit der Behälter zu gewährleisten.
Soziotechnische Gestaltung einer intelligenten Personaleinsatzplanung
Authors: Gabriel Stefan , Bentler Dominik , Bansmann Michael , Andrew Latos Benedikt , Kühn Arno , Dumitrescu Roman 
Published: February 2023

Abstract
In diesem Beitrag wird die soziotechnische Gestaltung einer Intelligenten Personaleinsatzplanung beim Unternehmen Miele & Cie. KG im Rahmen des Leuchtturmprojekts „InTime“ im Kompetenzzentrum Arbeitswelt.Plus beschrieben. Hierzu werden die Durchführung und Auswertung einer Interviewreihe sowie das daraus erarbeitete Soll-Konzept vorgestellt.
Systems & Life Cycle Engineering für Strategische Souveränität
Authors: Michels Nico , Bitzer Michael 
Published: February 2023

Abstract
Die Betrachtung von Produkt-Systemen über alle Phasen des Lebenszyklus gewinnt durch aktuelle Trends und deren Änderungsfrequenz zunehmend an strategischer Bedeutung für die Produktentwicklung. Der Ansatz des Systems & Life Cycle Engineerings kann hier genutzt werden, um die Innovation von Produkten zu unterstützen, um die Strategische Souveränität zu befähigen.
Klimamanagement zur Verbesserung der CO2-Bilanz in der Produktion
Authors: Budde Felix , Gellert Benjamin , Orth Ronald , Kohl Holger 
Published: February 2023

Abstract
Einzelne Klimaschutzmaßnahmen werden bereits von vielen Unternehmen erfolgreich umgesetzt. Doch oftmals fehlen ein systematischer Ansatz sowie die finanziellen Ressourcen zur Umsetzung eines konsequenten Klimaschutzes unter Beibehaltung des wirtschaftlichen Erfolgs. In diesem Beitrag wird ein Vorgehensmodell zur zielgerichteten und potenzialorientierten Ableitung und Umsetzung von Klimaschutzmaßnahmen im Rahmen eines betrieblichen Klimamanagements vorgestellt. Der Fokus liegt dabei auf kleinen und mittleren Unternehmen des produzierenden Gewerbes.
Effiziente Stagnationswasser-Entfernung in trinkwassertechnischen Anlagen
Authors: Gallin Paul , Rudolph Mathias , Brandt Ulf , Scheiba Stefan 
Published: February 2023

Abstract
Verweilzeiten zwischen werkseitiger Montage und Gebäudeinstallation führen bei trinkwassertechnischen Kompaktanlagen zur Stagnationswasser-Kontamination. Um die daraus resultierende Kontamination des Trinkwassernetzes bei einer Gebäudeinstallation zu vermeiden, sollte Restwasser bereits werksseitig entfernen werden. Im selben Prozessschritt können Anlagen desinfiziert oder sterilisiert werden. Im Rahmen eines Kooperationsprojektes wurde ein entsprechendes System entwickelt.
Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐NLRP3 inflammasomes
Authors: Enosi Tuipulotu Daniel , Feng Shouya , Pandey Abhimanu , Zhao Anyang , Ngo Chinh , Mathur Anukriti , Lee Jiwon , Shen Cheng , Fox Daniel , Xue Yansong , Kay Callum , Kirkby Max , Lo Pilato Jordan , Kaakoush Nadeem O , Webb Daryl , Rug Melanie , Robertson Avril AB , Tessema Melkamu B , Pang Stanley , Degrandi Daniel , Pfeffer Klaus , Augustyniak Daria , Blumenthal Antje , Miosge Lisa A , Brüstle Anne , Yamamoto Masahiro , Reading Patrick C , Burgio Gaetan , Man Si Ming 
Published: February 2023

AbstractMoraxella catarrhalis is an important human respiratory pathogen and a major causative agent of otitis media and chronic obstructive pulmonary disease. Toll‐like receptors contribute to, but cannot fully account for, the complexity of the immune response seen in M. catarrhalis infection. Using primary mouse bone marrow‐derived macrophages to examine the host response to M. catarrhalis infection, our global transcriptomic and targeted cytokine analyses revealed activation of immune signalling pathways by both membrane‐bound and cytosolic pattern‐recognition receptors. We show that M. catarrhalis and its outer membrane vesicles or lipooligosaccharide (LOS) can activate the cytosolic innate immune sensor caspase‐4/11, gasdermin‐D‐dependent pyroptosis, and the NLRP3 inflammasome in human and mouse macrophages. This pathway is initiated by type I interferon signalling and guanylate‐binding proteins (GBPs). We also show that inflammasomes and GBPs, particularly GBP2, are required for the host defence against M. catarrhalis in mice. Overall, our results reveal an essential role for the interferon‐inflammasome axis in cytosolic recognition and immunity against M. catarrhalis, providing new molecular targets that may be used to mitigate pathological inflammation triggered by this pathogen.
Ribosome biogenesis factors—from names to functions
Authors: Dörner Kerstin , Ruggeri Chiara , Zemp Ivo , Kutay Ulrike 
Published: February 2023

AbstractThe assembly of ribosomal subunits is a highly orchestrated process that involves a huge cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified by genetic screens and proteomic approaches of pre‐ribosomal particles in Saccharomyces cerevisiae. Later, research on human ribosome synthesis not only demonstrated that the requirement for many of these factors is conserved in evolution, but also revealed the involvement of additional players, reflecting a more complex assembly pathway in mammalian cells. Yet, it remained a challenge for the field to assign a function to many of the identified factors and to reveal their molecular mode of action. Over the past decade, structural, biochemical, and cellular studies have largely filled this gap in knowledge and led to a detailed understanding of the molecular role that many of the players have during the stepwise process of ribosome maturation. Such detailed knowledge of the function of ribosome biogenesis factors will be key to further understand and better treat diseases linked to disturbed ribosome assembly, including ribosomopathies, as well as different types of cancer.
Sperm utilize tumor necrosis factor alpha to shut down a 2-methoxyestradiol nongenomic pathway that accelerates oviductal egg transport in the rat
Authors: Oróstica María L , Reuquen Patricia , Guajardo-Correa Emanuel , Parada-Bustamante Alexis , Cardenas Hugo , Orihuela Pedro A 
Published: February 2023

In brief
Mating shuts down the 2-methoxyestradiol (2ME) nongenomic pathway that accelerates oviductal egg transport in the rat. This study shows that sperm cells, but not vaginocervical stimulation, utilize TNF-α to shut down this 2ME nongenomic pathway.

Abstract
The transport of oocytes or embryos throughout the oviduct to the implantation site in the uterus is defined as egg transport. In the rat, 2-methoxyestradiol (2ME) accelerates egg transport through the oviduct via a nongenomic pathway. Mating is known to shut down this 2ME pathway and then trigger an estradiol genomic pathway that accelerates egg transport. Here, we tested whether intrauterine insemination (IUI) or vaginocervical stimulation (VCS) shuts down the 2ME nongenomic pathway that accelerates egg transport, and if these mating components require tumor necrosis factor alpha (TNF-α). Levels of TNF-α and the mRNA for TNF-α receptors were measured in the oviduct of IUI or VCS rats. The tissue distribution of TNF-α receptor proteins and the concentration of the mRNA for catechol-O-methyl transferase (Comt) and 2ME were also analyzed in the oviduct. Finally, we assessed whether 2ME accelerates egg transport in IUI or VCS rats previously treated with the TNF-α antagonist W9P9QY. Results show that IUI, but not VCS, increased TNF-α and their receptors in the oviduct. IUI and VCS did not change the tissue distribution of TNF-α receptors; however, both decreased the oviductal concentration of Comt and 2ME. IUI and VCS each blocked the 2ME-induced egg transport acceleration; however, only the IUI was antagonized by the TNF-α antagonist. We concluded that IUI and VCS inhibit the 2ME nongenomic pathway that accelerates egg transport; however, the vias of action are distinct, with a TNF-α increase on spermatozoa presence being required for the shutdown of the 2ME pathway.
Sleep Apnea in Children With Down Syndrome
Authors: Seither Katelyn , Helm Benjamin M. , Heubi Christine , Swarr Daniel , Suhrie Kristen R. 
Published: February 2023

OBJECTIVE
The authors of this study aimed to evaluate the use of polysomnography (PSG) in children with Down syndrome (DS) between ages 0 and 7 years, to assess the prevalence and severity of obstructive sleep apnea (OSA) and associated comorbidities, and to describe interventions used for OSA.

METHODS
A retrospective cohort study was performed at Cincinnati Children’s Hospital Medical Center for children with DS born between 2013 and 2019. Data were extracted from the electronic medical record, including demographics, age at PSG, PSG results, and interventions after an abnormal PSG. Statistical analysis included unadjusted bivariate association testing and multivariable logistic regression modeling to investigate associations with OSA severity.

RESULTS
Among 397 patients in the cohort, 59% (n = 235) had a documented PSG and 94% (n = 221) had an abnormal study with 60% (n = 141) demonstrating moderate or severe OSA. There was an inverse relationship between age and OSA severity (P &lt; .001). In a multiple regression model, OSA severity was associated with increased rates of failure to thrive (P &lt; .01), aspiration (P = .02), and laryngomalacia (P &lt; .01). After medical or surgical intervention, 73% of patients experienced the resolution of OSA or an improvement in OSA severity.

CONCLUSION
In this study of pediatric patients with DS, OSA was identified most frequently in the first year of life. In addition, to prompt evaluation of symptomatic infants, our data support earlier PSG screening for patients requiring neonatal ICU care and those with feeding difficulties, airway abnormalities, and/or pulmonary hypertension given their increased risk for severe OSA.
An overview of approaches for modelling uncertainty in harmonic load-flow
Authors: Romero A. A. , Zini H. C. , Ratta G. 
Published: February 2023

Harmonic distortion is a growing problem in all power systems (PS) around the world due to the increasing use of electronic power devices and nonlinear loads (NLL). Several methods have been developed for the computational analysis of PS harmonic load-flow (HLF). These approaches allow harmonic distortion to be estimated at each PS bus when NLLs (the harmonic sources) are distributed throughout a whole network. Some widely accepted deterministic formulations are used in HLF analysis; however, harmonic distortion in PS is a time-varying phenomenon because both linear loads (LL) and NLLs change non-predictably all the time. Moreover, network configuration also varies and such considerations make HLF calculation a mathematical problem which must be able to model the uncertainty associated with input data. Some approaches based on probability theory and others using fuzzy sets and possibility theories have been proposed for modeling such uncertainty. This paper was thus aimed at providing an overview regarding these approaches. The main HLF formulations within probabilistic and possibilistic frameworks have thus been introduced and some numerical comparisons have been made to clarify some concepts raised.
Rating curve estimation using Envisat virtual stations on the main Orinoco river
Authors: León Juan , Seyler Frederique , Puerta Astrid 
Published: February 2023

Rating curve estimation (height-stream relation) made by hydrometric stations representing cross-sections of a river is one of hydrometrics' fundamental tasks due to the fact that it leads to deducing a river's average daily flow on that particular section. This information is fundamental in any attempt at hydrological modelling. However, the number of hydrological control stations monitoring large hydrological basins has been reduced worldwide. Space hydrology studies during the last five years have shown that satellite radar altimetry means that hydrological monitoring networks' available information can be densified due to the introduction of so-called virtual stations and the joint use of such information along with in-situ measured flow records for estimating expenditure curves at these stations. This study presents the rating curves for 4 Envisat virtual stations located on the main stream of the Orinoco River. Virtual stations' flows were estimated by using the Muskin-gum-Cunge 1D model. There was less than 1% error between measured and estimated flows. The methodology led to reducing average zero flow depth; in this case, it led to depths ranging from 11 to 20 meters being found along the 130 km of the Orinoco River represented by the virtual stations being considered.
AlN film deposition as a semiconductor device
Authors: Caicedo Julio Cesar , Pérez Taborda C , Chaparro Willian Aperador 
Published: February 2023

AlN films were deposited by pulsed laser deposition (PLD) using an Nd: YAG laser (λ = 1064 nm). The films were deposited in a nitrogen atmosphere as working gas; the cathode was an aluminium high purity (99.99%) target. The films were deposited using 7 J/cm2 laser fluence for 10 minutes on silicon (100) substrates. The working pressure was 9x10-3 mbar and the substrate temperature was varied from 200°C to 630°C. The thickness measured by profilometer was 150 nm for all films. Moreover, surface acoustic wave (SAW) devices with a Mo/AlN/Si configuration have been fabricated using AlN-buffer and Mo Channel. The films’ morphology and composition were studied using scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX), respectively. The films’ optical reflectance spectra and colour coordinates were obtained by optical spectral reflectometry in the 400-900 cm-1 range using an Ocean Optics 2000 spectrophotometer. The present work found clear dependence on morphological properties, reflectance, dominant wavelength colour purity, frequency response and acoustic wave speed in terms of the temperature applied to the substrate. About 30% reduction in reflectance was observed and increased acoustic wave speed of about 1.3 % when the temperature was increased from 200°C to 630°C.
Las clases virtuales en México durante la pandemia. Ventajas y desventajas
Authors: Martínez Aguilar José Manuel , Pérez Múzquiz Erika E. 
Published: February 2023

La modalidad de clases virtuales debido a la contingencia sanitaria provocada por la COVID-19 hace necesarios estudios diagnósticos que permitan conocer sus efectos en el proceso de aprendizaje-enseñanza. En este trabajo se confrontan las ventajas y desventajas de las clases virtuales, según la opinión de 350 estudiantes y 100 profesores de universidades públicas de México, obtenida mediante un sondeo hecho por los autores a través de Google Forms®. Entre los resultados obtenidos, se puede destacar que tanto los profesores como los estudiantes identifican más desventajas que ventajas respecto a las clases virtuales; sin embargo, ambos reconocen que debido a la pandemia era necesario continuar las clases bajo esta modalidad. Aunque hay diferencias entre las respuestas de profesores y estudiantes, y se identifica que la experiencia para los docentes ha sido más positiva, también hay coincidencias. Entre las desventajas mencionadas, sobresalen la falta de interacción personal, la poca motivación, el estrés que el encierro genera, la carencia de equipo y deficiencia de la señal de internet, entre otras. Algunas de las ventajas que más se mencionan son la facilidad de acceder a distintas fuentes por medios electrónicos, el ahorro económico y el adquirir nuevas habilidades informáticas.
Sacituzumab govitecan expands its therapeutic spectrum among breast cancer subtypes
Authors: Vranic Semir 
Published: February 2023

Antibody-drug conjugates (ADCs) are novel, highly potent drugs composed of a small molecule of an anticancer drug (payload)attached to humanized antibody recognizing an epitope on the surface of cancer cells. ADCs are rapidly expanding in the oncology field. By 2022, >180 ADC-based clinical trials have been conducted [1]. Most of these clinical trials are in phases I or II [1]. Several ADCs have been approved and used for the treatment of various malignancies (e.g., brentuximab vedotin (BV) for the treatment of CD30+ lymphomas, trastuzumab emtansine (T-DM1) for advanced/metastatic/or early-stage high-risk HER2-positive breast cancer with residual disease after neoadjuvant treatment) [2].
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Программа «Земский доктор» как фактор миграции врачей на периферию регионов Центрального федерального округа
Authors: Шарепина Екатерина Александровна 
Published: February 2023

Программа «Земский доктор» (далее Программа) в 2022 г. отмечает 10-летний юбилей, наряду с положительными эффектами исследователи и эксперты отмечают ряд проблем ее реализации и спорность достигнутых результатов. Существующие исследования конструируют социально-демографический «портрет» врачей-участников без привязки к мотивациям и направлениям переезда, что противоречит подходу рассмотрения процесса миграции как комплексного, обоснованного в теории push-pull факторов миграции Э. Ли. В данной работе представлена классификация стратегий, основанная на мотивациях к переезду (притягивающие и выталкивающие факторы); обстоятельствах, осложняющих процесс переезда; социально-демографических характеристиках врачей-мигрантов и их миграционных намерениях. Эмпирическая база исследования: биографические интервью с врачами – участниками Программы и экспертные интервью с руководителями и кадровыми службами медучреждений из 9 регионов Центрального федерального округа. В 5 из 6 выделенных стратегий переезд мотивируется совокупностью факторов и выходит за рамки только материальной мотивации. В большей степени остаются работать в медучреждениях те врачи – участники Программы, которые заинтересованы в переезде в более крупный или центральный населенный пункт или наоборот в «побеге» из предыдущего населенного пункта (используют средства Программы как стартовый капитал), а также те, кто получают выплаты при возвращении в родной населенный пункт по семейным причинам или для отработки целевого направления. Врачи, участвующие в Программе исключительно для получения материальных выплат, предпочитают формат маятниковых перемещений или оценивают свой переезд как временный. Основной практический вывод статьи заключается в том, что программы компенсационных выплат для более эффективной работы должны быть дополнены неэкономическими стимулами.