bluuebunny/crossref_metadata_2025_split huggingface dataset:
A system based on deep convolutional neural network improves the detection of early gastric cancer
Authors: Feng Jie , Yu Shang rui , Zhang Yao ping , Qu Lina , Wei Lina , Wang Peng fei , Zhu Li juan , Bao Yanfeng , Lei Xiao gang , Gao Liang liang , Feng Yan hu , Yu Yi , Huang Xiao jun 
Published: December 2022

BackgroundEarly gastric cancer (EGC) has a high survival rate, but it is difficult to diagnosis. Recently, artificial intelligence (AI) based on deep convolutional neural network (DCNN) has made significant progress in the field of gastroenterology. The purpose of this study was to establish a DCNN assist system to improve the detection of EGC.Methods3400 EGC and 8600 benign images were collected to train the DCNN to detect EGC. Subsequently, its diagnostic ability was compared to that of endoscopists using an independent internal test set (ITS, including 1289 images) and an external test set (ETS, including 542 images) come from three digestive center.ResultsThe diagnostic time of DCNN and endoscopists were 0.028s, 8.05 ± 0.21s, 7.69 ± 0.25s in ITS, and 0.028s, 7.98 ± 0.19s, 7.50 ± 0.23s in ETS, respectively. In ITS, the diagnostic sensitivity and accuracy of DCNN are 88.08%(95% confidence interval,95%CI,85.24%-90.44%), 88.60% (95%CI,86.74%-90.22%), respectively. In ETS, the diagnostic sensitivity and accuracy are 92.08% (95%CI, 87.91%- 94.94%),92.07%(95%CI, 89.46%-94.08%),respectively. DCNN outperformed all endoscopists in ETS, and had a significantly higher sensitivity than the junior endoscopists(JE)(by18.54% (95%CI, 15.64%-21.84%) in ITS, also higher than JE (by21.67%,95%CI, 16.90%-27.32%) and senior endoscopists (SE) (by2.08%, 95%CI, 0.75%-4.92%)in ETS. The accuracy of DCNN model was higher (by10.47%,95%CI, 8.91%-12.27%) than that of JE in ITS, and also higher (by14.58%,95%CI, 11.84%-17.81%; by 1.94%,95%CI,1.25%-2.96%, respectively) than JE and SE in ETS.ConclusionThe DCNN can detected more EGC images in a shorter time than the endoscopists. It will become an effective tool to assist in the detection of EGC in the near future.
Identifying diagnostic markers and constructing a prognostic model for small-cell lung cancer based on blood exosome-related genes and machine-learning methods
Authors: Zhang Kun , Zhang Chaoguo , Wang Ke , Teng Xiuli , Chen Mingwei 
Published: December 2022

BackgroundSmall-cell lung cancer (SCLC) usually presents as an extensive disease with a poor prognosis at the time of diagnosis. Exosomes are rich in biological information and have a powerful impact on tumor progression and metastasis. Therefore, this study aimed to screen for diagnostic markers of blood exosomes in SCLC patients and to build a prognostic model.MethodsWe identified blood exosome differentially expressed (DE) RNAs in the exoRBase cohort and identified feature RNAs by the LASSO, Random Forest, and SVM-REF three algorithms. Then, we identified DE genes (DEGs) between SCLC tissues and normal lung tissues in the GEO cohort and obtained exosome-associated DEGs (EDEGs) by intersection with exosomal DEmRNAs. Finally, we performed univariate Cox, LASSO, and multivariate Cox regression analyses on EDEGs to construct the model. We then compared the patients’ overall survival (OS) between the two risk groups and assessed the independent prognostic value of the model using receiver operating characteristic (ROC) curve analysis.ResultsWe identified 952 DEmRNAs, 210 DElncRNAs, and 190 DEcircRNAs in exosomes and identified 13 feature RNAs with good diagnostic value. Then, we obtained 274 EDEGs and constructed a risk model containing 7 genes (TBX21, ZFHX2, HIST2H2BE, LTBP1, SIAE, HIST1H2AL, and TSPAN9). Low-risk patients had a longer OS time than high-risk patients. The risk model can independently predict the prognosis of SCLC patients with the areas under the ROC curve (AUCs) of 0.820 at 1 year, 0.952 at 3 years, and 0.989 at 5 years.ConclusionsWe identified 13 valuable diagnostic markers in the exosomes of SCLC patients and constructed a new promising prognostic model for SCLC.
Analysis of the positive results and influencing factors of hepatitis B antibody in hospitalized neonates with AgHBs positive mothers
Authors: Min Yu xiao , Gao Ying , Liu Chun tian , Lu Xiao yu , Chen Xiao chun 
Published: December 2022

PurposeTo investigate the results of positive antibody to hepatitis surface antigen(anti-HBs)in hospitalized neonates whose mothers were hepatitis B surface antigen (AgHBs) positive and to explore the influencing factors.MethodThe study subjects were hospitalized neonates whose mothers were positive for AgHBs. According to the serological test results of five immune markers of hepatitis B virus (HBV), they were divided into positive for anti-HBs and negative for anti-HBs. Retrospective analysis of relevant factors affecting results of anti-HBs.Result269 cases (80.78%) were positive for anti-HBs and 64 cases (19.22%) were negative for anti-HBs. Univariate analysis results: the number of hepatitis B immunoglobulin (HBIG) injections after birth, whether HBIG was injected within 6 h, whether Hepatitis B vaccine (Hep B) was injected within 6 h, whether combined immunization within 12 h, whether Hep B was vaccinated on time after discharge, whether preterm birth, and whether low birth weight infants were statistically significant (P &lt; 0.05). The results of binary logistic regression analysis: HBIG injection time ≤6 h (OR = 0.213), combined immunization time ≤12 h (OR = 0.024) were protective factors; premature infants (OR = 7.175), ALB/GLO (OR = 9.792) and failure to complete three vaccinations on time (OR = 12.659) were risk factors (P &lt; 0.05).ConclusionAlthough China has implemented a national immunization program, vaccination of hospitalized neonates whose mothers are positive for AgHBs has not been effective. Therefore, it is recommended to strengthen training for medical staff and families to ensure that neonates can complete the three doses of vaccination on time after discharge from the hospital and to strengthen follow-up for premature infants.
FGF10 ameliorates lipopolysaccharide-induced acute lung injury in mice via the BMP4-autophagy pathway
Authors: Kong Xiaoxia , Lu Liling , Lin Daopeng , Chong Lei , Wen Shunhang , Shi Yaokai , Lin Lidan , Zhou Liqin , Zhang Hongyu , Zhang Hailin 
Published: December 2022

Introduction: Damage to alveolar epithelial cells caused by uncontrolled inflammation is considered to be the main pathophysiological change in acute lung injury. FGF10 plays an important role as a fibroblast growth factor in lung development and lung diseases, but its protective effect against acute lung injury is unclear. Therefore, this study aimed to investigate protective effect and mechanism of FGF10 on acute lung injury in mice.Methods: ALI was induced by intratracheal injection of LPS into 57BL/6J mice. Six hours later, lung bronchoalveolar lavage fluid (BALF) was acquired to analyse cells, protein and the determination of pro-inflammatory factor levels, and lung issues were collected for histologic examination and wet/dry (W/D) weight ratio analysis and blot analysis of protein expression.Results: We found that FGF10 can prevent the release of IL-6, TNF-α, and IL-1β, increase the expression of BMP4 and autophagy pathway, promote the regeneration of alveolar epithelial type Ⅱ cells, and improve acute lung injury. BMP4 gene knockdown decreased the protective effect of FGF10 on the lung tissue of mice. However, the activation of autophagy was reduced after BMP4 inhibition by Noggin. Additionally, the inhibition of autophagy by 3-MA also lowered the protective effect of FGF10 on alveolar epithelial cells induced by LPS.Conclusions: These data suggest that the protective effect of FGF10 is related to the activation of autophagy and regeneration of alveolar epithelial cells in an LPS-induced ALI model, and that the activation of autophagy may depend on the increase in BMP4 expression.
Methylome-wide association study of different responses to risperidone in schizophrenia
Authors: Du Huihui , Ma Jingsong , Zhou Wei , Li Mo , Huai Cong , Shen Lu , Wu Hao , Zhao Xianglong , Zhang Na , Gao Songyin , Wang Qi , He Lin , Wu Xuming , Qin Shengying , Zhao Mingzhe 
Published: December 2022

Background: Accumulating evidence shows that DNA methylation plays a role in antipsychotic response. However, the mechanisms by which DNA methylation changes are associated with antipsychotic responses remain largely unknown.Methods: We performed a methylome-wide association study (MWAS) to evaluate the association between DNA methylation and the response to risperidone in schizophrenia. Genomic DNA methylation patterns were assessed using the Agilent Human DNA Methylation Microarray.Results: We identified numerous differentially methylated positions (DMPs) and regions (DMRs) associated with antipsychotic response. CYP46A1, SPATS2, and ATP6V1E1 had the most significant DMPs, with p values of 2.50 × 10–6, 3.53 × 10–6, and 5.71 × 10–6, respectively. The top-ranked DMR was located on chromosome 7, corresponding to the PTPRN2 gene with a Šidák-corrected p-value of 9.04 × 10–13. Additionally, a significant enrichment of synaptic function and neurotransmitters was found in the differentially methylated genes after gene ontology and pathway analysis.Conclusion: The identified DMP- and DMR-overlapping genes associated with antipsychotic response are related to synaptic function and neurotransmitters. These findings may improve understanding of the mechanisms underlying antipsychotic response and guide the choice of antipsychotic in schizophrenia.
The vitellogenin receptor gene is involved in lifespan regulation of Zeugodacus cucurbitae (Coquillett) after short-term high-temperature treatment
Authors: Lian Yuyang , Peng Sihua , Yang Xiaofeng , Jia Jingjing , Li Jinlei , Wang Aqiang , Yang Shuyan , Zheng Rongjiao , Zhou Shihao 
Published: December 2022

Zeugodacus cucurbitae (Coquillett) is a highly damaging agricultural pest in many tropical and subtropical countries around the world and high temperatures usually affect its survival. To clarify the effect of short-term high temperatures on the survival and lifespan of Z. cucurbitae, newly emerged adults of three consecutive generations (F1, F2, and F3) were exposed to 25 °C, 33 °C, 37 °C, 41 °C, or 45 °C treatments for 1 h. The effect of these temperatures on survival and lifespan was evaluated using biological indicators such as lifespan and pupation rate. Then, to study the molecular regulatory mechanism of the lifespan of Z. cucurbitae after short-term high-temperature treatment, we exposed the newly emerged adults to 25 °C or 45 °C treatments for 1 h and used siRNA to interfere with the expression of the vitellogenin receptor (VgR) gene in the female to study the effect of the VgR gene on the lifespan of Z. cucurbitae. The results showed that the survival rate, lifespan, pupae weight, pupation rate, and emergence rate of Z. cucurbitae decreased with increased temperature, while the female sex ratio of offspring increased. The heat resistance of females was higher than that of males. Interference with the expression of the VgR gene resulted in shortening of the female’s lifespan by approximately 60% after exposure to 25 °C or 45 °C treatments for 1 h, which indicated involvement of the VgR gene in the regulation of Z. cucurbitae lifespan. This study provides a reference to guide integrated control of Z. cucurbitae in high-temperature seasons.
Characteristics and transcriptomic analysis of scar tissues on the inner uterine cavity wall in patients with intrauterine adhesions
Authors: Li Waixing , Gu Pan , Gao Bingsi , Zou Lingxiao , Zhang Aiqian , Huang Huan , Zhao Xingping , Xu Dabao , Cheng Chunxia 
Published: December 2022

Introduction: It has been previously reported that intrauterine adhesions (IUAs) are the main cause of uterine infertility. However, the histological origin of scar tissue present on the inner wall of the uterine cavity with IUAs has not been previously studied, which is particularly necessary for follow‐up research and prevention and treatment.Methods: In this study, myometrium with normal uterus were assigned to the control group and scar tissues with IUAs were assigned to the experimental group. And pathological characteristics and transcriptomic were analyzed between the two groups.Results: We founded no difference was noted in the histological morphology and the α-SMA expression between the experimental and control groups. A total of 698 differentially expressed genes were identified between the two groups. Gene Ontology (GO) analyses revealed that the DEGs were significantly enriched in cell proliferation, AP-1 complex formation, and angiogenesis. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses revealed that the target genes were significantly enriched in the AGE-RAGE, FOXO and TNF signaling pathway.Discussion: As far as we know, this is the first study to propose that the scar tissues are mainly derived from the myometrium and the first one to report differentially expressed genes in the scar tissues of IUAs.
A phenomenological exploration of work-related post-traumatic growth among high-functioning adults maltreated as children
Authors: Kaye-Tzadok Avital , Icekson Tamar 
Published: December 2022

IntroductionChildhood maltreatment is a highly prevalent traumatic experience, and its adverse psychological and behavioral consequences are well-documented. Notwithstanding these adverse outcomes, many individuals who suffered from traumatic experiences report post-traumatic growth, i.e., transformative positive changes resulting from their struggle to cope. Post-traumatic growth has been extensively explored among adult survivors of childhood maltreatment, with findings indicating both the previously recognized domains (personal strength, relating to others, appreciation of life, openness to new possibilities, and spiritual change) as well as abuse-specific domains of growth (e.g., increased ability to protect themselves from abuse). However, little attention has been given to vocational aspects of post-traumatic growth among survivors, despite the central role and importance of work in adulthood. Exploration of post-traumatic growth at work has focused on certain vocational traumatic experiences, such as those which occur in the military, or through secondary trauma. This exploratory qualitative study focuses on the question: What is the lived experience of work-related post-traumatic growth among high-functioning adult survivors of CM?MethodTwenty in-depth interviews were held with high-functioning working adults who were maltreated as children. Phenomenological analysis was applied to the retrospective data reported in these interviews.ResultRich descriptions of work-related positive psychological changes were provided by all participants. Analysis revealed that survivors’ post-traumatic growth corresponded with all five previously recognized domains of growth: changes in self, relating to others, openness to new possibilities, finding meaning to the abuse, and appreciation of life. It also revealed that work is perceived as a form of resistance (a subtheme of changes in self), and that finding meaning entails three emerging subthemes: being a survivor and a role model, giving others what was needed and never received, and making a better world.Discussion:While the vocational lives of survivors of childhood maltreatment have rarely been examined through the lens of post-traumatic growth, our results show this lens to be highly valuable. Work-related post-traumatic growth has relevance not only regarding vocational traumas occurring in adulthood as has been previously studied, but also in the context of childhood traumas. Moreover, our research broadens the understanding of the possible domains of work-related growth.
The role of leadership in collective creativity and innovation: Examining academic research and development environments
Authors: Huang Zijian , Sindakis Stavros , Aggarwal Sakshi , Thomas Ludivine 
Published: December 2022

IntroductionLeadership is pragmatically linked to innovation adoption and implementation at a team level, as managers oversee the strategic decisions and policymaking, control resources, and moderate the scanning and searching of the environment. The paper attempts to provide new concepts and examines theoretical and practical implications to better understand how the leadership role is executed in an R&amp;D environment to foster team creativity and innovation.MethodsA quantitative analysis was plausible over qualitative research mainly because the survey was conducted using a single technique, employing a questionnaire that was selected after checking the principal component analysis (PCA) and confirmatory factor analysis (CFA).ResultsThe findings show that the production of ideas positively impacts leadership, leading to growth and competitive advantage for the organization. Also, the PMEG (people, means, effects, goals) framework will positively impact leadership as leaders focus on those factorsthat influence an individual’s attitudes, behaviors, and interactions between groups.DiscussionThe paper highlights the involvement of R&amp;D organizations and groups in developing innovative products, services, technologies, and processes that further positively impact a team. This study is the first to highlight the role of the PMEG framework with the factors that influence an individual’s attitudes, behaviors, and interactions between groups. The study’s main contribution is to explore creativity as a potential mediator for leadership–organizational innovation.
Research on the consequences of employees’ unethical pro-organizational behavior: The moderating role of moral identity
Authors: Zhao Manlu , Qu Shiyou 
Published: December 2022

IntroductionIn recent years, employees’ unethical pro-organizational behavior (UPB) has become a social hot issue. This behavior benefits their organization or colleagues while violating core social ethics. Numerous studies have predominately focused on identifying the antecedents and formation mechanisms of UPB. However, only a few studies have focused on the effects and outcomes of UPB. Moreover, guilt triggered by unethical behaviors can motivate individuals to adopt pro-social behaviors, but studies on the effects of UPB on pro-social behavior of actors are rather limited. Therefore, this study explores the underlying relationship between employees’ UPB and their own pro-environmental behavior based on the conservation of resources theory.MethodsThrough collecting data (N = 319) from a Chinese online survey company in different time intervals, the theoretical model was tested by the application of Amos 27.0 and SPSS 25.0 for analysis of the data. The CFA, descriptive analysis, hierarchical regression were illustrated in the article.ResultsThis study demonstrated that, through emotions of guilt, employees’ UPB is negatively correlated with their own environmental protection act. While this relationship is being examined, moral identity plays this mediating role, which can moderate the indirect relationship between employees’ UPB and their environmental behavior through guilt.DiscussionThe purpose of the research was to identify the influence mechanisms that contribute to employees’ pro-organizational but unethical behavior. With guilt serving as the mediating variable and moral identity serving as the moderating variable, a research model built on the principle of the conservation of resources theory was constructed. This research examines the impact mechanism and boundary conditions of UPB on individual pro-environmental behaviors from the perspective of employees. This paper discusses the theoretical and practical implications of the report’s results.
Preschoolers’ temperament and social functioning in novel and routine contexts
Authors: Vaughan Helena Shoplik , Teglasi Hedwig 
Published: December 2022

IntroductionThe centrality of social competence to children’s short and long-term well-being has sparked interest in the factors that contribute to its development, including temperament, a set of biologically based dispositions. A large body of work documents two types of temperamental dispositions associated with young children’s social functioning: reactivity and regulation. There is consensus about the detrimental effects of negative reactive tendencies, called negative affective reactivity (NA), and about the beneficial effects of regulatory tendencies, called effortful control (EC), on social functioning. Another reactive component of temperament, Extraversion/Surgency (E/S) is less consistent in its relation with social functioning. Although NA is exacerbated by lack of familiarity, its contribution to social functioning in novel and routine contexts has not been systematically addressed.MethodsTo test this study’s hypotheses, we devised a structured interview of adaptive responsiveness in context (ARC) which was completed by parents of preschoolers along with a comprehensive temperament questionnaire. Additionally, children completed an individually administered task measuring emotion-situation knowledge (N = 92) and their teachers completed a standard social competence questionnaire.Results and DiscussionA path analysis that controlled for variance shared across contexts and temperamental traits showed that NA was the only unique predictor of social functioning in the Novel context, that EC was the only unique predictor of social functioning in the Routine context and that E/S was not a unique predictor of social functioning in either context. Bivariate analyses, conducted without controlling for context overlap, showed all reactive emotional traits (subsumed within NA and E/S) to correlate exclusively with ARC in the Novel contexts. However, regulatory traits showed a mixed pattern. Inhibitory Control correlated with ARC in both contexts but more highly in the Routine context, and Perceptual Sensitivity correlated with ARC in the Novel context.
Exercise improves the social and behavioral skills of children and adolescent with autism spectrum disorders
Authors: Toscano Chrystiane V. A. , Ferreira José P. , Quinaud Ricardo T. , Silva Keity M. N. , Carvalho Humberto M. , Gaspar Joana M. 
Published: December 2022

BackgroundCurrently, there is no standard treatment for Autism Spectrum Disorders (ASD), but there are many ways to minimize the symptoms and maximize abilities. Some studies suggest that exercise and other physical activities with children with ASD may be beneficial. In this study, we hypothesized that a physical exercise program (48-week exercise-intervention) could improve symptomatology dyad among children and adolescents with ASD. Our main aim was to examine the effects of physical activity on the primary clinical symptoms and associated comorbidities in children and adolescents with ASD.MethodsWe allocated 229 children with ASD, ranging in age from 2.3–17.3 years (M= 7.8,SD= 3.2), into three groups: (a) exercise- intervention group, (b) control group from the same institution, and (c) control group from another institution. The exercise program was performed at moderate intensity in a 30 min section twice a week for 48 weeks. We used Bayesian multilevel regression modeling to examine participant outcomes and responses to the exercise-intervention.ResultsOur results showed that a 48-week exercise-intervention substantially decreased ASD social interaction problems, attention deficit, emotional reactivity, stereotypical verbal and motor behavior, and sleep disturbances. However, physical exercise did not affect eye contact and food selectivity. We also observed that ASD severity and socioeconomic status influence eye contact, attention deficit, and sleep disturbance responses.ConclusionIn conclusion, children and adolescents with ASD exposed to a 48-week physical exercise-intervention program had important improvements in ASD symptoms. This study highlights that structured exercise programs can be a powerful complementary therapy for the ASD population.