bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influenza transmissibility among patients and health-care professionals in a geriatric short-stay unit using individual contact data
Authors: Gustin Marie-Paule , Pujo-Menjouet Laurent , Vanhems Philippe 
Published: June 2023

AbstractDetailed information are lacking on influenza transmissibility in hospital although clusters are regularly reported. In this pilot study, our goal was to estimate the transmission rate of H3N2 2012-influenza, among patients and health care professionals in a short-term Acute Care for the Elderly Unit by using a stochastic approach and a simple susceptible-exposed-infectious-removed model. Transmission parameters were derived from documented individual contact data collected by Radio Frequency IDentification technology at the epidemic peak. From our model, nurses appeared to transmit infection to a patient more frequently with a transmission rate of 1.04 per day on average compared to 0.38 from medical doctors. This transmission rate was 0.34 between nurses. These results, even obtained in this specific context, might give a relevant insight of the influenza dynamics in hospitals and will help to improve and to target control measures for preventing nosocomial transmission of influenza. The investigation of nosocomial transmission of SARS-COV-2 might gain from similar approaches.
Small mammals reduce activity during high moon illumination under risk of predation by introduced predators
Authors: Taylor P. , Swan M. , Sitters H. , Smith A. , Di Stefano J. 
Published: June 2023

AbstractPredation influences prey survival and drives evolution of anti-predator behaviour. Anti-predator strategies by prey are stimulated by direct encounters with predators, but also by exposure to indicators of risk such as moonlight illumination and vegetation cover. Many prey species will suffer increased risk on moonlit nights, but risk may be reduced by the presence of dense vegetation. Determining the role of vegetation in reducing perceived risk is important, especially given predictions of increased global wildfire, which consumes vegetation and increases predation. We used remote cameras in southeastern Australia to compare support for the predation risk and habitat-mediated predation risk hypotheses. We examined the influence of moonlight and understorey cover on seven 20–2500 g mammalian prey species and two introduced predators, red foxes and feral cats. Activity of all prey species reduced by 40–70% with increasing moonlight, while one species (bush rat) reduced activity in response to increasing moonlight more sharply in low compared to high understorey cover. Neither predator responded to moonlight. Our findings supported the predation risk hypothesis and provided limited support for the habitat-mediated predation risk hypothesis. For prey, perceived costs of increased predation risk on moonlit nights outweighed any benefits of a brighter foraging environment.
A procedure and model for the identification of uni- and biarticular structures passive contribution to inter-segmental dynamics
Authors: Koussou Axel , Dumas Raphaël , Desailly Eric 
Published: June 2023

AbstractInter-segmental moments come from muscles contractions, but also from passive moments, resulting from the resistance of the periarticular structures. To quantify the passive contribution of uni- and biarticular structures during gait, we propose an innovative procedure and model. 12 typically developed (TD) children and 17 with cerebral palsy (CP) participated in a passive testing protocol. The relaxed lower limb joints were manipulated through full ranges of motion while kinematics and applied forces were simultaneously measured. The relationships between uni-/biarticular passive moments/forces and joint angles/musculo-tendon lengths were modelled by a set of exponential functions. Then, subject specific gait joint angles/musculo-tendon lengths were input into the determined passive models to estimate joint moments and power attributable to passive structures. We found that passive mechanisms contribute substantially in both populations, mainly during push-off and swing phases for hip and knee and push-off for the ankle, with a distinction between uni- and biarticular structures. CP children showed comparable passive mechanisms but larger variability than the TD ones and higher contributions. The proposed procedure and model enable a comprehensive assessment of the passive mechanisms for a subject-specific treatment of the stiffness implying gait disorders by targeting when and how passive forces are impacting gait.
Applying cosmetic oil with added aromatic compounds improves tactile sensitivity and skin properties
Authors: Samain-Aupic Léonard , Gilbert Laura , André Nathalie , Ackerley Rochelle , Ribot-Ciscar Edith , Aimonetti Jean-Marc 
Published: June 2023

AbstractTactile sensitivity generally decreases with aging and is associated with impairments in skin properties. Products that hydrate the skin can combat touch deficits and aromatic compounds have been shown to improve skin mechanical properties. Thus, we tested a base cosmetic oil against a perfumed oil, applied to the skin of females aged 40–60 years, on tactile sensitivity and skin properties after repeated application. Tactile detection thresholds were assessed using calibrated monofilaments applied at the index finger, palm, forearm, and cheek. Spatial discrimination on the finger was assessed using pairs of plates with different inter-band spaces. These tests were performed before and after 1 month of base or perfumed oil use. We found that tactile detection thresholds and spatial discrimination improved only in perfumed oil group. A complementary immunohistological study using human skin was conducted to estimate the expression of olfactory receptor OR2A4 and elastic fiber length. Further, the expression of OR2A4 intensity and the length of elastic fibers increased significantly with oil application, where larger effects were seen with the perfumed oil. We conclude that the application of a perfumed oil may be of additional benefit and could repair, and even prevent, tactile decline with aging by ameliorating skin condition.
Reasons for high prevalence of contraceptive withdrawal in Tehran, Iran
Authors: Erfani Amir , Kolahi Ali-Asghar 
Published: June 2023

AbstractThis study explores reasons for withdrawal use that is highly prevalent in Iran. A face-to-face semi-structured survey questionnaire was designed and 79 married women aged 15–49, who were only using withdrawal when attending five primary healthcare centers in Tehran during September–October 2021 were interviewed. Results showed that withdrawal mostly was chosen by the couple (67%), and partly by the woman alone (19%) or by the husband alone (14%). Participants evaluated withdrawal positively that has no side effect and cost, is easy to use and accessible, and increases sexual pleasure and intimacy. Most women agreed that husbands use withdrawal to protect their wife's health (76%). Women obtained contraceptive information primarily from gynecologists (42%), the internet (21%), midwives in public health centers (19%), and social networks (18%). "Side effects of modern methods" (37%), "fear of side effects" (16%), and "reduction in sexual pleasure" (14%) were the major reasons reported for using withdrawal. While 'side effects' was given mostly by women who alone or with their husband chose withdrawal (52%, 38%), 'reduction in sexual pleasure' and 'fear of side effects' were mostly reported by women whose husband was the sole decision maker in choosing withdrawal (28%, 25%). The 'fear of side effects' was reported mostly by women who had lower education (21%), used the internet for contraceptive information (23%), and whose husband alone chose withdrawal (25%). Cost of modern methods was a trivial reason for using withdrawal. Most withdrawal users (75%) would not switch to modern methods even if they were freely accessible. More educated women and their husbands would be less likely to switch to modern methods even they were provided freely (OR 0.28, CI 0.10–0.80; OR 0.20, CI 0.07–0.59). However, women who were using modern methods before, and those who alone chose withdrawal would be more likely to switch to modern methods (OR 6.4, CI 2.0–20.2; OR 3.4, CI 1.1–11.2). Access to regular contraceptive counselling and public health campaigns could help women to deal with fears of side effects of modern methods, learn their proper use, and to receive education on how to use withdrawal more effectively to avoid unintended pregnancies.
Stabilizer codes for open quantum systems
Authors: Pereira Francisco Revson F. , Mancini Stefano , La Guardia Giuliano G. 
Published: June 2023

AbstractThe Lindblad master equation describes the evolution of a large variety of open quantum systems. An important property of some open quantum systems is the existence of decoherence-free subspaces. A quantum state from a decoherence-free subspace will evolve unitarily. However, there is no procedural and optimal method for constructing a decoherence-free subspace. In this paper, we develop tools for constructing decoherence-free stabilizer codes for open quantum systems governed by the Lindblad master equation. This is done by pursuing an extension of the stabilizer formalism beyond the celebrated group structure of Pauli error operators. We then show how to utilize decoherence-free stabilizer codes in quantum metrology in order to attain the Heisenberg limit scaling with low computational complexity.
Portable impedance-sensing device for microorganism characterization in the field
Authors: Bouzid Karim , Greener Jesse , Carrara Sandro , Gosselin Benoit 
Published: June 2023

AbstractA variety of biosensors have been proposed to quickly detect and measure the properties of individual microorganisms among heterogeneous populations, but challenges related to cost, portability, stability, sensitivity, and power consumption limit their applicability. This study proposes a portable microfluidic device based on impedance flow-cytometry and electrical impedance spectroscopy that can detect and quantify the size of microparticles larger than 45 µm, such as algae and microplastics. The system is low cost ($300), portable (5 cm $$\times$$
×
5 cm), low-power (1.2 W), and easily fabricated utilizing a 3D-printer and industrial printed circuit board technology. The main novelty we demonstrate is the use of square wave excitation signal for impedance measurements with quadrature phase-sensitive detectors. A linked algorithm removes the errors associated to higher order harmonics. After validating the performance of the device for complex impedance models, we used it to detect and differentiate between polyethylene microbeads of sizes between 63 and 83 µm, and buccal cells between 45 and 70 µm. A precision of 3% is reported for the measured impedance and a minimum size of 45 µm is reported for the particle characterization.
Evaluation of the cardiac subvolume dose and myocardial perfusion in left breast cancer patients with postoperative radiotherapy: a prospective study
Authors: Wang Shan-Ying , Lin Kuan-Heng , Wu Yen-Wen , Yu Chih-Wei , Yang Shu-Ya , Shueng Pei-Wei , Hsu Chen-Xiong , Wu Tung-Hsin 
Published: June 2023

AbstractAdjuvant breast radiotherapy could reduce the risk of local recurrence. However, the radiation dose received by the heart also increases the risk of cardiotoxicity and causes consequential heart diseases. This prospective study aimed to evaluate more precisely cardiac subvolume doses and corresponding myocardial perfusion defects according to the American Heart Association (AHA)’s 20-segment model for single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) interpretation for breast cancer after radiotherapy. The 61 female patients who underwent adjuvant radiotherapy following breast cancer surgery for left breast cancer were enrolled. SPECT MPI were performed before radiotherapy for baseline study, and 12 months after for follow-up. Enrolled patients were divided into two groups, new perfusion defect (NPD) and non new perfusion defect found (non-NPD) according to myocardial perfusion scale score. CT simulation data, radiation treatment planning, and SPECT MPI images were fused and registered. The left ventricle was divided into four rings, three territories, and 20 segments according to the AHA’s 20-segment model of the LV. The doses between NPD and non-NPD groups were compared by the Mann–Whitney test. The patients were divided into two groups: NPD group (n = 28) and non-NPD group (n = 33). The mean heart dose was 3.14 Gy in the NPD group and 3.08 Gy in the non-NPD group. Mean LV doses were 4.84 Gy and 4.71 Gy, respectively. The radiation dose of the NPD group was higher than the non-NPD group in the 20 segments of LV. There was significant difference in segment 3 (p = 0.03). The study indicated that the radiation doses to 20 segments of LV in NPD were higher than those in non-NPD significantly at segment 3, and higher in other segments in general. In the bull’s eye plot combining radiation dose and NPD area, we found that the new cardiac perfusion decline may exist even in the low radiation dose region.Trial registration: FEMH-IRB-101085-F. Registered 01/01/2013, https://clinicaltrials.gov/ct2/show/NCT01758419?cond=NCT01758419&draw=2&rank=1.
Mate genetic similarity affects mating behaviour but not maternal investment in mice
Authors: Auer Kerstin E. , Primus Jasmin , Istel Sonja , Dahlhoff Maik , Rülicke Thomas 
Published: June 2023

AbstractMaternal investment can affect the survival and development of offspring. Here we experimentally investigated in mice, whether females alter implantation rates and pup survival after embryo transfer depending on the genetic similarity with their vasectomised mating partner. We selected the MHC genotype and genetic background of males and paired females either with males that shared the same MHC haplotype and genetic background (CBA/J inbred males, isogenic group), that shared half of the MHC haplotype and genetic background (B6CBAF1 hybrid males, semi-isogenic group), or that had a different MHC haplotype and genetic background (C57BL/6N inbred males, allogenic group). We performed 304 pairings, resulting in 81 vaginal plugs, which confirmed mating. Plug rates were significantly higher in the semi-isogenic group (36.9%) compared to the isogenic group (19.5%), but not the allogenic group (26%). We found no difference in the number of implantation sites, the number of born or surviving pups until weaning, or litter weight or sex ratio between groups. Even though we found a mating bias, we found no difference in maternal investment under laboratory conditions. At least under pathogen-free conditions our study does not provide any evidence for differential maternal investment when females could increase offspring genetic diversity or heterozygosity.
Positive rate of wheat allergens in the Chinese allergic population: a systematic review and meta-analysis
Authors: Yang Fengmei , Zhao Xinyi , Liu Wenfeng , Zhou Bo , Deng Lili , Chen Hongbing , Zhang Zhuo , Zhou Lin 
Published: June 2023

AbstractIn recent years, the prevalence of allergic diseases has increased significantly, causing great concern, and wheat, as one of the top 8 food allergens, is a common allergy trigger. Nevertheless, reliable estimates of the positivity rate of wheat allergens in the allergic population in China are still lacking. The systematic review and meta-analysis aims to evaluate the positive detection rate of wheat allergens in the Chinese allergic population and further provide a reference for the prevention of allergy. CNKI, CQVIP, WAN-FANG DATA, Sino Med, PubMed, Web of Science, Cochrane Library, and Embase databases were retrieved. Related research and case reports about the positive rate of wheat allergen in the Chinese allergic population published from inception to June 30, 2022, were searched, and meta-analysis was performed using Stata software. The pooled positive rate of wheat allergens and 95% confidence interval were calculated by random effect models, and the publication bias was evaluated using Egger’s test. A total of 13 articles were included for the final meta-analysis, in which wheat allergen detection methods involved only serum sIgE testing and SPT assessment. The results showed that the wheat allergen positivity detection rate in Chinese allergic patients was 7.30% (95% CI 5.68–8.92%). Subgroup analysis showed that the positivity rate of wheat allergens was influenced by region, but hardly by age and assessment method. The positive rates of wheat allergy in the population with allergic diseases were 2.74% (95% CI 0.90–4.58%) and 11.47% (95% CI 7.08–15.87%) in southern and northern China, respectively. In particular, the positive rates of wheat allergens were greater than 10% in Shaanxi, Henan and Nei Mongol, all of which belong to the northern region. These results suggest that wheat allergens are an important cause of sensitization in allergic populations from northern China, and therefore attention should be paid to early prevention in high-risk populations.
Identification of hypoxia-related genes and exploration of their relationship with immune cells in ischemic stroke
Authors: Yang Kai , Zhang Zhaoqi , Liu Xiaoju , Wang Tong , Jia Zhicheng , Li Xin , Liu Wei 
Published: June 2023

AbstractIschemic stroke (IS) is a major threat to human health, and it is the second leading cause of long-term disability and death in the world. Impaired cerebral perfusion leads to acute hypoxia and glucose deficiency, which in turn induces a stroke cascade response that ultimately leads to cell death. Screening and identifying hypoxia-related genes (HRGs) and therapeutic targets is important for neuroprotection before and during brain recanalization to protect against injury and extend the time window to further improve functional outcomes before pharmacological and mechanical thrombolysis. First, we downloaded the GSE16561 and GSE58294 datasets from the NCBI GEO database. Bioinformatics analysis of the GSE16561 dataset using the limma package identified differentially expressed genes (DEGs) in ischemic stroke using adj. p. values < 0.05 and a fold change of 0.5 as thresholds. The Molecular Signature database and Genecards database were pooled to obtain hypoxia-related genes. 19 HRGs associated with ischemic stroke were obtained after taking the intersection. LASSO regression and multivariate logistic regression were applied to identify critical biomarkers with independent diagnostic values. ROC curves were constructed to validate their diagnostic efficacy. We used CIBERSORT to analyze the differences in the immune microenvironment between IS patients and controls. Finally, we investigated the correlation between HRGs and infiltrating immune cells to understand molecular immune mechanisms better. Our study analyzed the role of HRGs in ischemic stroke. Nineteen hypoxia-related genes were obtained. Enrichment analysis showed that 19 HRGs were involved in response to hypoxia, HIF-1 signaling pathway, autophagy, autophagy of mitochondrion, and AMPK signaling pathway. Because of the good diagnostic properties of SLC2A3, we further investigated the function of SLC2A3 and found that it is closely related to immunity. We have also explored the relevance of other critical genes to immune cells. Our findings suggest that hypoxia-related genes play a crucial role in the diversity and complexity of the IS immune microenvironment. Exploring the association between hypoxia-related critical genes and immune cells provides innovative insights into the therapeutic targets for ischemic stroke.
Changes in group behaviour in response to a preferred environment reflect positive affect
Authors: Kleinhappel Tanja K. , Pike Thomas W. , Burman Oliver H. P. 
Published: June 2023

AbstractWhen observed in their preferred environments, animals display behavioural changes, such as an increase in resting or a reduction in agonism, suggestive of positive affect and improved welfare. However, most studies focus on the behaviour of individuals or, at most, pairs of animals; even though in group-living animals beneficial environmental changes may impact on how the group behaves as a whole. In this study, we investigated whether experiencing a preferred visual environment affected the shoaling behaviour of zebrafish (Danio rerio) groups. We first confirmed a group preference for an image of gravel placed underneath the base of a tank compared to a plain white image. Second, we observed replicated groups either with or without the preferred (gravel) image present to determine if a visually enriched and preferred environment could elicit changes in shoaling behaviour. We found a significant interaction between the observation time and test condition, with differences in shoaling behaviour reflective of increased relaxation emerging gradually over time in the gravel condition. The findings of this study reveal that experiencing a preferred environment can alter group behaviour, making such holistic changes valuable as potential indicators of positive welfare.
Stratospheric influences on surface ozone increase during the COVID-19 lockdown over northern China
Authors: Chen Zhixiong , Liu Jane , Cheng Xugeng , Yang Mengmiao , Shu Lei 
Published: June 2023

AbstractSurface ozone increased unexpectedly over northern China during the COVID-19 lockdown (CLD) period (23 January–29 February 2020), which was characterized by vigorous emission reduction. The reasons for this ozone enhancement have been speculated from perspectives of chemical responses to the emissions and meteorology. As known, the processes of natural stratospheric ozone injecting to the troposphere are most active in winter and spring. Yet, little attention was paid to stratospheric influences on this ozone enhancement. Here we report a stratospheric intrusion (SI) that reached the surface over northern China on 15–17 February during the CLD. The coevolution of enhanced ozone and sharply declined carbon monoxide and relative humidity (RH) was indicative of the SI occurrence. We show that the SI was facilitated by a cutoff low system that led to abnormally high surface ozone in most part of northern China. We estimate that over the SI period, the injected stratospheric ozone constituted up to 40–45% of the surface ozone over northern China. If the stratospheric ozone inputs were scaled over the entire CLD period, these inputs would account for 4–8% of the surface ozone. In view of the unexpected ozone increase during the CLD, this SI event could explain up to 18% of the ozone increase in some cities, and average 5–10% over larger areas that were affected. Hence, the nonnegligible stratospheric influences urge extra consideration of natural ozone sources in disentangling the role of emission reduction and meteorological conditions during the CLD in China and elsewhere in the world.
Single atom in a superoscillatory optical trap
Authors: Rivy Hamim Mahmud , Aljunid Syed A. , Lassalle Emmanuel , Zheludev Nikolay I. , Wilkowski David 
Published: June 2023

AbstractOptical tweezers have become essential tools to manipulate atoms or molecules at a single particle level. However, using standard diffraction-limited optical systems, the transverse size of the trap is lower bounded by the optical wavelength, limiting the application range of optical tweezers. Here we report trapping of single ultracold atom in an optical trap that can be continuously tuned from a standard Airy focus to a subwavelength hotspot smaller than the usual Abbe’s diffraction limit. The hotspot was generated using the effect of superoscillations, by the precise interference of multiple free-space coherent waves. We argue that superoscillatory trapping and continuous potential tuning offer not only a way to generate compact and tenable ensembles of trapped atoms for quantum simulators but will also be useful in single molecule quantum chemistry and the study of cooperative atom-photon interactions within subwavelength arrays of quantum emitters.