bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilaterally Paralel Elliptic Flap Versus Karydakis Flap in Pilonidal Sinus Disease: A Randomized Controlled Trial
Authors: TURAN Umut Fırat , COBAN Serdar , AKIN Tezcan , BERKEM Huseyin , YUKSEL Bulent Cavit , ER Sadettin 
Published: May 2023

Abstract
Purpose
Pilonidal sinus disease is a disease that especially affects the young population and causes loss of workforce. Although many treatment methods have been defined, there is still no ‘gold standard’ treatment method. Our objective was to evaluate the postoperative results of bilateral parallel elliptical flap and karydakis flap in the surgical treatment of pilonidal sinus.
Methods
This study was conducted at the Colorectal Surgery Department of Ankara Numune Training and Research Hospital. It designed a prospective randomized controlled study. Patients that underwent surgery due to pilonidal sinus were included in the study. The patients were randomly divided into two groups. Surgery was performed with the bilateral parallel elliptical flap (BPEF) technique in one group and the karydakis flap (KF) technique in the other group. Postoperative pain, length of hospital stay, wound complications, time taken to return to work/school, and recurrence incidence were evaluated.
Results
A total of 102 patients were included in the study, 49 in the BPEF group and 53 in the KF group. The length of hospital stay was similar in the BPEF and KF groups (1.41 ± 0.81 and 1.45 ± 0.84, respectively; p > 0.05). There was less postoperative pain in the BPEF group (2.47 ± 1.02 vs 3.57 ± 1.10, p < 0.05). Wound complications were observed in nine patients in the BPEF group (18.2%) and 14 patients in the KF group (26.2%). The time to return to work/school was shorter in the BPEF group (21.06 ± 6.37 vs 27.04 ± 7.45; p < 0.05). Recurrence developed in two (4%) patients in the BPEF group and three (5.6%) patients in the KF group (p > 0.05).
Conclusions
The patients who underwent surgery with the bilateral parallel elliptical flap technique had less pain and a shorter time to return to work/school after the operation. The postoperative complication and recurrence rates were similar in both groups.
Trial Registration clinicaltrials.gov identifier: NCT05851690. (5/11/2023) (retrospectively registered)
Effects of Pentazocine on perioperative myocardial injury of elderly hypertensive patients
Authors: Tang Na , Li Chen 
Published: May 2023

Abstract
BACKGROUNDː To observe the effect of Pentazocine on elderly hypertensive patients with preoperative and postoperative cardiac troponin I (cTnI) concentration and the occurring rate of cardiovascular events;Analysis whether Pentazocine can reduce the perioperative myocardial injury of patients with non-cardiac surgery and play a role in myocardial protection. METHODSːSelective the hip replacement under spinal anesthesia of elderly hypertensive patients of the Second Affiliated Hospital of Shanxi Medical University from Nov. 2020 to June. 2021. 79 cases were randomly divided into two group :Pentazocine group (P group, n = 39), Control group (C group, n = 40);Monitor and record the blood pressure (BP), heart rate (HR), pulse oxygen saturation (SpO2), electrocardiogram (ECG) and intraoperative adverse cardiovascular events.With the use of ELISA to determinate the preoperative and 24h-postoperative cardiac troponin I (cTnI) concentrations. RESULTSː1. When compared with the moment entering the operating room, in both group, the mean arterial pressure (MAP), heart rate (HR), pulse oxygen saturation (SpO2) have significant statistical difference (P < 0.05)with the time after the surgury; the MAP, HR, SpO2 have no difference between the two groups in both of the time (P > 0.05). 2. The incidence of adverse cardiovascular events in P group was 10.3%(4/39), it was significantly lower than that of C group27.5%(11/40),which has significant statistical difference (P < 0.05).3. the concentrations of cTnI were not different before surgery (P > 0.05) between the two groups,the cTnI concentrations in the two groups after 24h of the surgery were both higher than those before the surgery, and the increasing range of P group was significantly lower than that in C group (P < 0.05). CONCLUSIONSː 1. The hip joint replacement have significant hemodynamic changes on elderly patients with hypertension and may cause different degrees of myocardial injury;2. Pentazocine can significantly reduce the impact of the damage on patients's myocardium;The myocardial protective effect may exist.
Optical solitons of a perturbed Biswas-Milovic equation with parabolic-law nonlinearity and spatio-temporal dispersion
Authors: Cinar Melih 
Published: May 2023

Abstract
This paper deals with a new variant of the Biswas-Milovic equation, referred to as the perturbed Biswas-Milovic equation with parabolic-law nonlinearity in spatio-temporal dispersion. To our best knowledge, the considered equation which models the pulse propagation in optical fiber is studied for the first time, and the abundant optical solitons are successfully obtained utilizing the auxiliary equation method. Furthermore, we also investigate the impact of the parameters such as the spatio-temporal dispersion and the parabolic nonlinearity on the behavior of the soliton. The auxiliary equation method was employed due to its effectiveness in extracting abundant and diverse kinds of soliton solutions, including bright, kink, and singular. It has been tested and verified using Mathematica that all solutions obtained satisfy the main equation. 3D, 2D, and contour graphs of the solution functions are plotted and interpreted to understand the physical behavior of the model. The new model and findings may contribute to the understanding and characterization of the nonlinear behavior of pulse propagation in optical fibers, which is crucial for the development of optical communication systems.
The effect of preoperative endoscopic tattooing on lymph node retrieval in colorectal cancer: a systematic review and meta-analysis
Authors: Nawras Mohamad , Chawla Karan , DeRiso Armelle , Dubchuk Christina , Beran Azizullah , Aziz Muhammad , Pannell Stephanie 
Published: May 2023

Abstract
Purpose
The effect of preoperative endoscopic tattooing (ET) on accurate colorectal cancer localization and resection has been well established. However, its effect on lymph node (LN) retrieval remains unclear. The purpose of this study was to systematically compare LN retrieval between patients with colorectal cancer who underwent preoperative ET and those who did not.
Methods
A systematic search for relevant studies was conducted using the following databases: PubMed, Embase, and Web of Science. Studies that compared LN retrieval in patients with colorectal cancer with and without preoperative ET were included. Weighted pooled odds ratio (OR) and mean difference (MD) with the corresponding 95% confidence intervals (CIs) for all outcomes using the random-effects model were calculated.
Results
10 studies, including 2231 patients with colorectal cancer were included. Six studies reported total LN yield and showed significantly higher LN yield in the tattooed group (MD:2.61; 95% CI:1.01–4.21, P = 0.001). Seven studies reported the number of patients with adequate LN retrieval and showed a significantly higher number of patients with adequate LN retrieval in the tattooed group (OR:1.89, 95% CI:1.08–3.32, P = 0.03). However, subgroup analysis revealed that both outcomes were only statistically significant in patients with rectal cancer, and not in patients with colon cancer.
Conclusions
Our results suggest that preoperative ET is associated with increased LN retrieval in patients with rectal cancer, but not in colon cancer. Further large-scale randomized control trials are necessary to validate our findings.
Research on deep gas geological laws and gas prediction: A case study of the Lvjiatuo coal mine
Authors: Li Wu , Cui Minrui , Hu Changqing 
Published: May 2023

Abstract
With the increasing demand for gas, the problem of local anomalies in deep gas urgently needs to be addressed. This study takes the Lvjiatuo coal mine as the research area, analyzes the main influencing factors of coal seam gas accumulation law in the research area, and predicts the deep gas content in the research area based on a neural network model optimized by particle swarm optimization (PSO-BP). The research results indicate that the development of folds and fault structures only plays a certain degree of control over the accumulation and distribution of gas content in the coal seams of Lvjiatuo coal mine, and the burial depth of the coal seams is the dominant factor affecting the deep gas accumulation in the research area; The mud content of coal seam roof has a significant impact on gas accumulation, and under similar geological factors, the higher the mud content of coal seam roof, the more gas content there is; The PSO-BP neural network model based on the data of coal seam burial depth, structural complexity index, roof mud content, and coal seam thickness in the research area can accurately predict the deep gas content in the area, and the predicted values are accurately fitted with the measured values; The research results have important theoretical and practical significance for studying the law of deep gas accumulation and predicting deep gas content.
Delineation of Groundwater Potential zone using geospatial tools and Analytical Hierarchy Process (AHP) in the State of Uttarakhand, India
Authors: Singh Atar , Kumar Rajesh , Kumar Ramesh , Pippal Prity Singh , Sharma Payal , Tanuja . , Sharma Abhilasha 
Published: May 2023

Abstract

Groundwater plays a vital role in global climate change and substantial human needs. However, the groundwater potential zone (GWPZ) delineation is essential for fulfilling livelihood needs. In recent years, studies based on geographic information systems (GIS) have acquired much attention in groundwater exploration. Therefore, in this study, we use a multi-criteria decision analysis (MCDA) based analytical hierarchy process (AHP) model, with overlay weighted linear combination method, to identify the groundwater potential zone in the state of Uttarakhand. Remote sensing (RS) images and conventional data for a geographic information system (GIS) were used to generate nine thematic layers, geomorphology, geology, LULC, drainage density, slope, Rainfall, soil, TWI, and curvature for groundwater potential zone demarcation. In addition, the AHP technique was used to identify the weight of the parameters and GIS tools for the overlay analysis. To determine the groundwater potential zone, a thematic map was given ratings of 'very poor', 'poor', 'moderate', 'good', 'very good' and 'excellent'. The results reveal that the area covered in the 'very poor' categories is 187.43 km2 (0.16%), 'poor' 2109.66 km2 (3.99%), 'moderate' 29024.06 km2 (54.78%), 'good' 15151.13 km2 (28.67%), 'very good' 6537.19 km2 (12.37%), and 'excellent' 814.84 km2 (1.55%) accordingly. The 'very poor' and 'moderate' groundwater potential zones were observed at 0.16% and 54.78%, respectively, and the possibility for GPZ gradually increased from the northeast to the southwest. The findings of this study have implications for future research on sustainable groundwater use, basin management, agriculture, and the link between groundwater and climate change.
Systematization, symbolization and microbicidal activeness of 3-amino 5,6-dimethoxyl-2-methyl derivatives Via 4H–benzo[d] [1,3]–oxazine–4–one and quinazolin-4-(3H)-one
Authors: Osarumwense P. O , Edwma M. O , USIFOH C. O , ERHUNSE M 
Published: May 2023

Abstract
The concentration of 2-amino-methyl-4, 5-dimethoxybenzoate with acetic anhydride yielded the cyclic compound 2-methyl-4, 5-disubstituted-1, 3-benzo-oxazine-4-one which further produce a novel 2,3-disubstituted quinazolin-4 ones via the reaction with hydrazine hydrate. The compounds synthesized were unequivocally confirmed by means of Infrared, Nuclear Magnetic Resonance (1H and 13C), Gas Chromatography Mass Spectrophotometer and Elemental analysis. The synthesized compounds were screened against various strains of microorganism; Staphylococcus aureus, Bacillus species, Escherichia coli, Klebsiella pneumonia, Serratia marcescens, and candida albicans. Compounds 1 and 2 showed significant activity against Staphylococcus aureusand Serratia marcescenswith MIC ranging from 6 – 12 mg/mL.
Effect of Fe3O4 coated bacterial consortium IQMJ-5 on the desulfurization of the organosulfur portion of Pakistani coal and its chemical characteristics
Authors: Khan Javed , Ali Muhammad Ishtiaq , Achakzai Jahangir Khan , Jamal Asif , Uddin Siraj , Liaquat Rabia 
Published: May 2023

Abstract
Coal is an abundant and inexpensive source of energy with immense application in different industrial sectors. However, its extensive utilization has resulted in several kinds of sulfur-related environmental issues. To tackle such issues, indigenously isolated Fe3O4-coated bacterial consortium IQMJ-5 cells were applied for the desulfurization of a Pakistani coal. The coated cells were allowed to desulfurize the coal in a shake flask experiment. To assess the desulfurization capabilities, both the pre- and post-desulfurized coal were characterized by different chemical and analytical techniques. The total sulfur content identified in the coal sample was about 4.50%. The results of the analysis showed that after treatment an increase in the carbon content and heating value of the coal sample was detected. Moreover, an amount of about 54.46% and 66.6% of organic and total sulfur, respectively were removed after biodesulfurization. The obtained results clearly suggest that the consortium can be a potential candidate for reducing sulfur-related environmental pollutants of fossil fuels at a more advanced commercial scale.
Propensity-matched analysis of robotic versus sternotomy approaches for mitral valve replacement
Authors: Yan Wenlong , Wang Yangyang , Wang Wei , Wang Qingjiang , Zheng Xin , Yang Sumin 
Published: May 2023

Abstract
Background
To compare early and medium-term outcomes between robotic and sternotomy approaches for mitral valve replacement (MVR).
Methods
Clinical data of 1393 cases who underwent MVR between January 2014 and January 2023 were collected and stratified into robotic MVR (n = 186) and conventional sternotomy MVR (n = 1207) groups. The baseline data of the two groups of patients were corrected by the propensity score matching (PSM) method.
Results
After matching, the baseline characteristics were not significant different between the two groups (standardized mean difference < 10%). Moreover, the rates of operative mortality (P = 0.663), permanent stroke (P = 0.914), renal failure (P = 0.758), pneumonia (P = 0.722), and reoperation (P = 0.509) were not significantly different. Operation, CPB and cross-clamp time were shorter in the sternotomy group. On the other hand, ICU stay time, post-operative LOS, intraoperative transfusion, and intraoperative blood loss were shorter or less in the robot group. Operation, CPB, and cross-clamp time in robot group were all remarkably improved with experience. Finally, all-cause mortality (P = 0.633), redo mitral valve surgery (P = 0.739), and valve-related complications (P = 0.866) in 5 years of follow-up were not different between the two groups.
Conclusions
Robotic MVR is safe, feasible, and reproducible for carefully selected patients with good operative outcomes and medium-term clinical outcomes.
Appendiceal actinomycosis: a case series with clinical, radiologic and histopathologic correlation
Authors: Montero Javier Arredondo , Vega Elena Carracedo , Villegas Irene Amat 
Published: May 2023

Abstract
Background: Actinomycosis is an infrequent chronic infection caused by Actinomyces israeli. Appendiceal actinomycosis is a highly uncommon pathology, with isolated reports in the literature to date.
Case report: We report 3 patients diagnosed of appendiceal actinomycosis. Two of our patients were male and one was female. The age range was 29-73 years. One patient presented as a complicated acute appendicitis (AA), other as a non-complicated AA and the last one followed a subacute course. Two of the patients received antibiotherapy for less than 2 weeks while one patient was treated for 12 months. All patients evolved favorably and did not present recurrences. AA was confirmed in two cases. Actinomyces colonies were identified and confirmed by different targeted stains in all cases.
Conclusions: Appendiceal actinomycosis is an infrequent pathology whose clinical presentation can be very variable. Future studies that characterize this entity in diagnostic, therapeutic and prognostic terms are required.
The ALKBH5/USP36 complex in glioblastoma is unstable and could be disrupted to facilitate temozolomide therapy
Authors: Lehrer Steven , Rheinstein Peter 
Published: May 2023

Abstract
Background: Alpha-ketoglutarate dependent dioxygenase-5 (ALKBH5), a de-ubiquinating enzyme, is abnormally activated and plays important functions in glioblastoma formation. Ubiquitin-specific peptidase 36 (USP36) is crucial for maintaining ALKBH5 stability and controlling ALKBH5-mediated gene expression in glioblastoma stem cells. Reduced cell proliferation, worsened self-renewal, and increased sensitivity to temozolomide (TMZ) therapy were all effects of USP36 depletion. Elucidation of the ALKBH5/USP36 complex structure may therefore facilitate the development of drugs that can block complex formation.
Methods: We have used the ClusPro web server for protein-protein docking to visualize and analyze the complex and GROMACS to perform molecular dynamics simulation.
Results: ClusPro protein docking analysis demonstrates the loose peripheral position of ALKBH5 in the ALKBH5/USP36 complex. Molecular dynamics simulation of ALKBH5 docked to USP36 suggests that ALKBH5/USP36 is not a stable structure.
Conclusion: The results of protein-protein docking and molecular dynamics simulation imply that the ALKBH5/USP36 complex is not stable and might be disrupted by a therapeutic molecule or molecules, improving the prognosis of glioblastoma. Knowledge of the ALKBH5/USP36 complex structure may facilitate the development of drugs that can block or disrupt complex formation.
Cost-effectiveness of prehabilitation prior to elective surgery: A systematic review of economic evaluations
Authors: Rombey Tanja , Eckhardt Helene , Kiselev Jörn , Silzle Julia , Mathes Tim , Quentin Wilm 
Published: May 2023

Abstract
Background

Prehabilitation aims at enhancing patients’ functional capacity and overall health status to enable them to withstand a forthcoming stressor like surgery. Our aim was to synthesise the evidence on the cost-effectiveness of prehabilitation for patients awaiting elective surgery compared with usual preoperative care.

Methods

We searched PubMed, Embase, the CRD database, ClinicalTrials.gov, the WHO ICTRP and the dissertation databases OADT and DART. Studies comparing prehabilitation for patients with elective surgery to usual preoperative care were included if they reported cost outcomes. All types of economic evaluations (EEs) were included regardless of design, analysis type and completion status. The primary outcome of the review was cost-effectiveness based on cost-utility analyses (CUAs).
The risk of bias of trial-based EEs was assessed with the Cochrane Risk of Bias 2 tool and the ROBINS-I tool, and the credibility of model-based EEs with the ISPOR checklist. Methodological quality of full EEs was assessed using the CHEC checklist. The EEs’ results were synthesised narratively using vote counting based on direction of effect.

Results

We included 45 unique studies: 25 completed EEs and 20 ongoing studies. Among the completed EEs, there were 22 trial-based EEs, and three model-based EEs, corresponding to four CUAs, three cost-effectiveness analyses, two cost-benefit analyses, 12 cost-consequence analyses and four cost-minimization analyses. Three of the four trial-based CUAs (75%) found prehabilitation cost-effective. Overall, 16/25 (64.0%) EEs found prehabilitation cost-effective based on direction of effects. When excluding studies of insufficient credibility/critical risk of bias, this number reduced to 14/23 (60.9%). In 8/25 (32.0%) cost-effectiveness was unclear, and in one EE prehabilitation was not cost-effective.

Discussion

We found some evidence that prehabilitation for patients awaiting elective surgery is cost-effective compared to usual preoperative care. However, we suspect a relevant risk of publication bias, and most EEs were of high risk of bias and/or low methodological quality. Furthermore, there was relevant heterogeneity depending on the population, intervention, and methods. Future EEs should be performed over a longer time horizon and apply a more comprehensive perspective.

Funding information and systematic review registration

Funding: Innovationsausschuss of the Federal Joint Committee (G-BA) (01NVF18024).
Registration: PROSPERO CRD42020182813.
Impact of Special Economic Zones on Export Diversification in Sub-Saharan Africa
Authors: SUKADI Emmanuel SUKADI A 
Published: May 2023

Abstract

Export diversification is a major concern for policymakers in Sub-Saharan Africa (SSA). Over the past 30 years, many countries of the region have adopted special economic zone (SEZ) programs with the aim of fostering industrial development and export-led growth. By offering various pro-investment incentives, SEZs are expected to contribute to the improvement of the business climate and attract firms from traditional and new sectors. This study analyses the impact of SEZ adoption on overall export diversification and on extensive and intensive margins in the SSA region. For that purpose, a difference-in-differences approach has been implemented on a panel of 32 SSA countries covering the period 1970–2014. It appears that SEZ adoption has contributed to balancing export shares more equally among traditional sectors, resulting in greater export diversification in these countries. However, this policy tool has appeared to be less effective in fostering the creation of new activity sectors.
Use of a combined topical preparation in the complex treatment of thrombophlebitis of the superficial veins of the lower extremities
Authors: Melnikov M. A. , Katorkin S. E. , Kushnarchuk M. Yu. , Kravtsov P. F. 
Published: May 2023

Introduction. Treatment of thrombophlebitis should be complex and, along with mandatory compression, include both systemic and local use of drugs.Aim. To evaluate the efficacy and safety of the standardized use of the combined drug gel containing heparin sodium, aescin and essential phospholipids in real clinical practice in the treatment of superficial vein thrombophlebitis.Materials and methods. The study included 68 patients with varicose veins complicated by superficial vein thrombophlebitis. In group 1 patients (n = 33), topical drugs were not used. In group 2 patients (n = 35), combined gel was used daily. The drug was applied to the skin of the lower extremities three times a day, 1 g of gel. Its total daily amount did not exceed 4 g of gel. The observation period was 10 days. A dynamic scoring of clinical symptoms was performed using alinear analog scale and thermometry of the skin of the lower extremities.Results. On day 10, patients of the main group showed a statistically significant decrease in thermographic parameters in the area of thrombophlebitis: Tmin 33.23 ± 0.12 °C, Tmax 39.86 ± 0.24 °C, Tmean 40.01 ± 0.16 °С (p ≤ 0.05). When assessing the symptoms of thrombophlebitis using alinear analog scale after 10 days of treatment, there was a general decrease in the number of points in the control group to 16.4 ± 0.12 and in the main group to 12.3 ± 0.16 points (p ≤ 0.05).Conclusion. A combined gel is an effective and safe drug for the treatment of patients with thrombophlebitis of the superficial veins of the lower extremities.