bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge mapping of autophagy in chronic obstructive pulmonary disease from 2004 to 2024: a bibliometric analysis
Authors: Zhang Yating , Li Anqi , Xu Sumei , Liu Haoge 
Published: February 2025

BackgroundChronic obstructive pulmonary disease (COPD) has become a major global healthcare issue due to its high prevalence and mortality rates. Increasing evidence suggests that autophagy plays a role in the development of COPD, yet there is a lack of bibliometric analyses on literature related to autophagy and COPD. Therefore, this study aims to summarize the current research status, research direction, and research hotspots in the literature related to COPD and autophagy.MethodsA search was conducted on the Web of Science Core Collection for literature related to COPD and autophagy from October 2004 to October 2024. Subsequently, bibliometric and visualization analyses were performed on the included publications using R software, CiteSpace, and VOSviewer.ResultsA total of 481 published articles across 229 journals related to COPD and autophagy were included. During the study period, there was a trend of continuous growth in both the annual number of publications and citations in this field. The United States had the highest centrality, while China was the most productive country. Major research institutions included Maastricht University, Harvard University, and Jikei University. The American Journal of Physiology-Lung Cellular and Molecular Physiology, International Journal of Chronic Obstructive Pulmonary Disease, and Autophagy are the most influential journals in this field. The author with the most published papers is Araya J, while Choi AMK is the most influential author. Frequently appearing keywords include “oxidative stress,” “obstructive pulmonary disease,” “aging,” “apoptosis,” and “mitophagy.”ConclusionThis bibliometric study helps researchers quickly understand the research overview of autophagy and COPD, thus providing new insights and directions for future research in this field.
The effect of Zexie decoction on vestibular and auditory function in DDAVP-induced endolymphatic hydrops of Guinea pigs
Authors: Ji Renlong , Xu Yanchang , Li Kang , Jiang Wen , Li Yuan , Zeng Jianwei , Li Wei , Wang Caiji , Zhao Zeqi , Li Yalan , Konduru Naveena , Liu Wen , Qiao Yuehua , Li Xuanyi 
Published: February 2025

ObjectiveTo investigate the effects of Zexie decoction on vestibular and auditory function in guinea pigs with endolymphatic hydrolysis induced by desmopressin. Methods: Sixty guinea pigs were randomly and evenly divided into four groups, each group has 15 guinea pigs: normal control group, DDAVP group, DDAVP modeling combined with Zexie Decoction group, and DDAVP combined with Double Zexie group. At 7 and 14 days, bone-conducted cervical vestibular evoked myogenic potential tests, auditory brainstem responses, and distortion-product otoacoustic emissions were conducted on each group of guinea pigs to evaluate their vestibular and auditory function quantitatively. After functional testing, the outer hair cells were observed by scanning electron microscope. On day 14, one guinea pig was randomly selected from both the normal control group and DDAVP group to verify the successful establishment of the model using gadolinium-enhanced magnetic resonance imaging of the inner ear.ResultsWe conducted BC-cVEMP, ABR, and DPOAE tests on guinea pigs, and the results showed that DDAVP did affect vestibular function and hearing in guinea pigs. Analyses were performed from those results that were statistically significant, Zexie Decoction improved DDAVP-induced vestibular dysfunction and hearing loss dose-dependently, though complete reversal was not achieved. About scanning electron microscopy, outer hair cells of the DDAVP group showed significant loss and cilia lodging, however, treatment with Zexie decoction can alleviate the loss of outer hair cells and the lodging of cilia. When the outer hair cells were exposed to DDAVP for a long time, the improvement effect of Zexie decoction was not as obvious as before.ConclusionThe extent of improvement correlates with the concentration and dosage of Zexie Decoction. Even at double the dosage, Zexie Decoction only partially mitigates the decline in vestibular and auditory function induced by DDAVP, falling short of complete reversal.
Association of ADHD and LD with vision abnormalities among the children and adolescents in US, NHANES 1999–2004
Authors: Lu Jiamin , Zhou Kefan , Liang Yingyu , Li Qishan , Zhong Jiawen , Zeng Xia , Shen Tianran , Sun Chongzhen , Yu Xinping , Lu Jinhua , Yang Wenhan 
Published: February 2025

ObjectiveTo examine the association of ADHD and LD with visual impairment, uncorrected refractive error, and refractive error (myopia, hyperopia, and astigmatism) among US children and adolescents.MethodA population-based cross-sectional study included 3,385 participants aged 12–15 years from the large, representative sample of US NHANES. The diagnoses of ADHD and LD in children and adolescents, as reported by parents or adolescents themselves, were analyzed. All participants’ right eyes were used to calculate the spherical equivalent refractive errors (SER) during the investigation. Myopia, hyperopia, and astigmatism were classified by SER. Visual acuity was categorized into normal, uncorrected refractive error (URE), and visual impairment (VI) according to objectively assessed for each eye. Logistic regression analysis was used to estimate the associations between ADHD and LD and vision abnormalities.ResultsAmong a total of 3,385 children and adolescents aged 12–15 years, 279 were reported to have a diagnosis of ADHD, and 427 were reported to have a diagnosis of LD. Compared with those without ADHD, children and adolescents with ADHD had an increased risk of hyperopia, with odds ratios (ORs) of 1.66 (95% CI, 1.03–2.67). LD was associated with higher risks of hyperopia (OR = 1.85, 95% CI, 1.17–2.90) and astigmatism (OR = 1.63, 95% CI: 1.18–2.26). After controlling for confounding variables, the results remained stable. LD also increased the risk of vision impairment (OR = 3.05, 95% CI: 1.05–8.90) after controlling for confounders. Stratified analyses showed that ADHD was a risk factor for hyperopia in boys compared with girls (OR = 1.62, 95%CI = 1.03–2.72), in 12–13-year-old individuals compared with 14–15-year-olds (OR = 1.69, 95%CI = 1.05–3.42). LD was a risk factor for hyperopia and astigmatism in girls compared with boys (OR = 2.81, 95%CI = 1.53–5.14; OR = 2.18, 95%CI = 1.22–3.90), and in 12–13-year-old individuals compared with 14–15-year-olds (OR = 1.99, 95%CI = 1.16–3.42; OR = 1.65, 95%CI = 1.07–2.56).ConclusionChildren and adolescents diagnosed with ADHD and LD may be at a greater risk of developing hyperopia and astigmatism. To accurately diagnose and treat children affected by ADHD and LD, healthcare practitioners from various medical specialties should take this association into account.
Potential of transcranial ultrasound- and near-infrared spectroscopy-based acute stroke imaging for decision-making on intravenous thrombolysis treatment
Authors: Freitag Erik , Erdur Hebun , Khalil Ahmed A. , Harmel Peter , Kaffes Maximilian , Schmitz Christoph H. , Weber Joachim E. , Audebert Heinrich J. 
Published: February 2025

BackgroundMobile Stroke Units (MSU) shorten time to intravenous thrombolysis (IVT) and improve functional outcome, but they rely on computed tomography (CT) making them highly specialized and costly. Alternative technologies can potentially identify imaging-based IVT contraindications like intracranial hemorrhage (ICH) or malignancies (IM), e.g., by transcranial color-coded sonography (TCCS) and near-infrared spectroscopy (NIRS).MethodsUsing a simulation approach, we analyzed magnetic resonance imaging (MRI) scans of stroke-suspected patients within 4.5 h of symptom onset to assess TCCS and NIRS for identifying imaging-based IVT contraindications. Our study included both primary and sensitivity analyses, each employing conservative and optimistic scenarios. The primary analysis integrated clinical information from the emergency department, while the sensitivity analysis evaluated overall performance across all patients, regardless of clinical information. The conservative scenario defined TCCS detecting acute deep-brain hemorrhages or tumors &gt;20 mm from scalp surface or &gt; 10 mL in volume or causing &gt;4 mm midline-shift, while NIRS was defined detecting them &lt;20 mm from scalp surface with a volume &gt; 3.5 mL. The optimistic scenario defined TCCS detecting intracranial or subarachnoid acute/subacute hematoma or tumors &gt;20 mm from scalp surface or &gt; 5 mL in volume or causing &gt;2 mm midline-shift, while NIRS was defined detecting them &lt;35 mm from the scalp surface with volume &gt; 3.5 mL.ResultsWe assessed 1,089 consecutive patients undergoing acute MRI, identifying 69 with imaging-based IVT contraindications, of which 40 had additional non-imaging contraindications. In the primary analysis, among those 29 patients without non-imaging-based contraindications, TCCS/NIRS would have detected 15 of 25 ICH and 3 of 4 malignant tumors in the conservative scenario. In the optimistic scenario, 18 of 25 ICH and all malignant tumors would have been detected. In the sensitivity analyses, the conservative scenario would have detected 30 of 52 ICH and 8 of 17 malignant tumors, while the optimistic scenario would have identified 37 of 52 ICH and 12 of 17 malignant tumors.ConclusionWhile TCCS and NIRS technologies exhibit potential for identifying IVT contraindications in pre-hospital settings, comprehensive evaluation in real-world scenarios is imperative to ascertain their operational constraints.
Cueing-assisted gamified augmented-reality gait-and-balance rehabilitation at home for people with Parkinson’s disease: protocol of a pragmatic randomized controlled trial implemented in the clinical pathway
Authors: Geerse Daphne J. , Hoogendoorn Eva M. , van Doorn Pieter F. , van Bergem Jara S. , van Dam Annejet T. , Hardeman Lotte E. S. , Roerdink Melvyn 
Published: February 2025

BackgroundPhysiotherapy in the clinic is highly recommended for improving gait, balance, and fall risk in people with Parkinson’s disease. In addition, technology may help boost unsupervised exercise hours at home. Strolll is an augmented-reality (AR) neurorehabilitation platform for delivering gait-and-balance exercises onto AR glasses that can be performed under direct supervision of the therapist in the clinic, but also independently at home. Strolll AR also has the option to integrate AR cueing in gait-and-balance exercises to assist people with more severe mobility impairments in performing the exercises. The objective of this pragmatic randomized controlled trial (RCT) on Strolll AR is to examine its clinical feasibility and effectiveness for improving indicators of gait, balance, and falls risk. A secondary objective is to evaluate procedures for tailoring assistive AR cues.MethodsA total of 100 people with Parkinson’s disease (Hoehn and Yahr stages 1–3) with gait and/or balance impairments will participate in this study. This study is a pragmatic RCT in which all participants follow the same procedure. After a baseline assessment (T0), participants will start with a 6-week usual care control period, followed by a midterm assessment (T1). Subsequently, participants will undergo 2 weeks of in-clinic familiarization with Strolll AR. Then, participants will start with the 6-week Strolll AR intervention at home, followed by a final in-clinic assessment (T2). The primary study parameters are feasibility (i.e., safety, adherence, performance, and user experience) and effectiveness for improving indicators of gait, balance, and falls risk. For the statistical analyses on effectiveness, participants will be allocated to control (using T0-T1 change data) or intervention (using T1-T2 change data) groups using multiple (n = 20) randomizations. Recruitment started in May 2024 and the last T2 assessment is expected in February 2025.DiscussionThe design of this particular pragmatic RCT will demonstrate feasibility and effectiveness in a real-world setting and in a representative population. Strolll AR may facilitate the transition from supervised care in the clinic to independent care at home, providing a platform for delivering individualized treatment, assisted with AR cues when deemed beneficial, for improving gait, balance, and falls risk in people with Parkinson’s disease.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT06590987
Contributing factors to acute malnutrition among children admitted to public health facilities in South West Ethiopia: a matched case–control study
Authors: Tamiru Dessalegn , Girma Shimelis , Gizaw Getu 
Published: February 2025

IntroductionIn Ethiopia, acute malnutrition is one of the potential challenges to achieving the United Nations’ Sustainable Development Goals in reducing child mortality. Thus, this study aimed to determine factors associated with acute malnutrition among children aged 6–59 months attending public health facilities in Jimma town, South West Ethiopia, from March to December 2017.MethodsAn institution-based age-matched case–control study design was used. Two hundred and thirty-four children aged 6 to 59 months were randomly selected. Data were analyzed using SPSS version 20. Variables with a p-value of ≤0.25 in the bivariate analyses were entered into a multivariable regression analysis to determine the independent predictors of acute malnutrition.ResultsThis study showed that lack of maternal education (AOR = 4.08, 95% CI, 1.46, 11.40), poor child feeding (AOR = 5.97, 95% CI, 1.83, 19.44), low wealth index (AOR = 3.76, 95% CI, 1.24, 11.38), less hand washing (AOR = 5.57, 95% CI, 1.82, 16.97), exposure to diarrhea (AOR = 3.58, 95% CI, 1.15, 11.07), and bottle-feeding (AOR = 3.98, 95% CI, 1.29, 12.36) were significantly associated with acute malnutrition among children attending public health facilities in Jimma town.ConclusionThe findings of this study indicated that the sex of the child, family size, household wealth index, bottle-feeding, and maternal knowledge of child feeding were found to be independent predictors of acute malnutrition. Therefore, emphasis should be given to strengthening caregivers’ socioeconomic status and improving the knowledge of mothers regarding childfeeding practices.
Cardiovascular toxicity induced by immunotherapy in non-small cell lung cancer: a systematic review and meta-analysis of observational studies
Authors: Sabaté-Ortega Josep , Teixidor-Vilà Eduard , Sais Èlia , Hernandez-Martínez Alejandro , Montañés-Ferrer Claudia , Coma Núria , Polonio-Alcalá Emma , Pineda Victor , Bosch-Barrera Joaquim 
Published: February 2025

BackgroundImmune checkpoint inhibitors (ICIs), an immunotherapy used in cancer treatment, are associated with potential cardiovascular (CV) toxicity. Monitoring CV issues in non-small cell lung cancer (NSCLC) patients is challenging due to their lower incidence and diversity. Hence, enhancing our understanding of CV toxicities in patients receiving ICIs is required to improve their quality of life and survival. Hence, the main objective of this study is the evaluation of CV side effects in ICI-treated NSCLC patients by assessing the prevalence and hazard of CV events.MethodsA systematic review was conducted to identify relevant studies, up to November 21st, 2023. A meta-analysis was performed to examine the data extracted from the selected studies. The random-effects model was applied to account for heterogeneity among studies, reporting results as prevalence rates and hazard ratios (HR) alongside their corresponding 95% confidence intervals (CI). Studies meeting inclusion criteria were selected and outcomes were assessed through qualitative analysis.ResultsTwelve observational studies using Real world Data were included, encompassing 23,621 patients with NSCLC. Our findings indicated that patients treated with ICIs exhibited a 3% prevalence of CV events and a significantly higher hazard (HR = 1.78 (95% CI: 1.46, 2.17); p &lt; 0.00001; I2 = 72%) compared to patients treated with other drugs.ConclusionsThe treatment with ICIs caused a higher rate of CV events compared to non-ICI treatments. Nevertheless, further research is required to elucidate the underlying mechanisms and implications for patient care. This calls for continued research efforts to optimize the cardiovascular health of patients undergoing immunotherapy for lung cancer.
Association between serum oxidative stress indicators, inflammatory indicators and suicide attempts in adolescents with major depressive disorder
Authors: Peng Cao , Xu Mengting , Ye Meng , Yang Weiwei , Fang Maosheng 
Published: February 2025

BackgroundProgress in research on the neurobiology of suicide behavior in adolescents has notably lagged compared to that of adults. This study aimed to investigate the associations between serum indicators, including oxidative stress (OS) and inflammatory indicators, and psychological factors with suicide attempts (SA) in adolescents with major depressive disorder (MDD) while also exploring potential markers.MethodsThis study involved the psychological assessment of 106 first-time hospitalized adolescents aged 12 to 18 with MDD and the measurement of serum indicators. Participants were categorized into two groups according to their history of SA within the preceding six months. Screening the best markers for suicide by machine learning algorithms. Multivariable logistic regression was used to assess the correlation between these indicators and suicide. Secondly, Mendelian randomization (MR) was used to initially explore the causal relationship between these serum indicators and suicide.ResultsIn adolescents diagnosed with MDD, those who had attempted suicide exhibited elevated serum superoxide dismutase (SOD) activity, reduced nitric oxide (NO) levels, more severe anxiety and depressive symptoms, worse sleep quality, increased exposure to adverse life events, less effective coping strategies, worse parental attachment, more severe alexithymia, and more impulsivity when compared to their counterparts without a history of SA (all p&lt;0.05). The multivariable analyses showed a significant association between serum SOD activity (OR 1.254, 95% CI 1.043-1.534) and anxiety symptoms (OR 1.056, 95% CI 1.020-1.097) with SA in adolescents diagnosed with MDD. The MR analyses showed a causal association between genetically determined low uric acid (UA) levels and a higher risk of SA (OR 0.942 95%CI 0.896-0.991).ConclusionSerum SOD activity, anxiety symptoms, and UA levels may be potential markers of SA and suicide intent in adolescents with MDD.
Healthcare professionals’ knowledge, attitudes, and practice of podoconiosis management and associated factors in public hospitals in Ilu Ababor and Buno Bedelle zones, Southwest Ethiopia: a cross-sectional study
Authors: Tamiru Sanbato , Lulu Yohanis , Bidira Kebebe , Amsalu Bonsa , Duguma Abdissa , Nigusu Yared , Gezimu Wubishet 
Published: February 2025

BackgroundPodoconiosis is non-filarial lymphoedema of the lower extremities. It impairs individuals’ overall lives, including their health, economy, psychology, and social interactions. Podoconiosis is a preventable and effectively manageable disease. The insights and skills of healthcare professionals are vital for the prevention and management of podoconiosis. However, healthcare professionals’ knowledge, attitudes, and practices of podoconiosis management have been poorly studied in Ethiopia.ObjectiveThe study aimed to assess the healthcare professionals’ knowledge, attitudes, and practices toward podoconiosis management and associated factors in public hospitals in the Ilu Ababor and Buno Bedelle Zones.MethodsA facility-based cross-sectional study was conducted from December 1, 2022, to January 1, 2023. The data were collected from systematically selected health professionals using a self-administered structured questionnaire. Epi-data and SPSS were used for data entry and analysis, respectively. A binary logistic regression analysis was used to identify factors influencing the outcome variables. In the multivariable analysis, a p-value of ≤0.05 was used to pronounce statistical significance at a 95% confidence interval.ResultsFrom the total of 399 participants involved, 262 (65.7%) had poor knowledge, 213 (54.3%) had unfavorable attitudes, and 308 (77.2%) had never practiced podoconiosis management. Years of experience, level of education, type of qualification, podoconiosis training, taking courses in education curricula, and attitudes were identified as factors influencing knowledge. The participants’ attitudes were influenced by age, podoconiosis training, receiving technical support, and knowledge. Their practices were significantly affected by age, education level, podoconiosis training, taking podoconiosis courses in educational curricula, and knowledge.ConclusionThe current study found poor healthcare professionals’ insights and skills in podoconiosis management in the study area. Therefore, concerned bodies need to set up capacity-building training and guidelines for healthcare professionals in the area to boost their knowledge, attitudes, and practice toward podoconiosis management.
Evaluating the effectiveness and limitations of online health information tools in assessing the quality of medication-related content
Authors: Alhlayl Adel S. , Alzghaibi Haitham A. 
Published: February 2025

IntroductionThe internet has become a primary source of information on medicines, yet the quality of this information is inconsistent. Despite the proliferation of web-based resources, limited research has specifically examined the reliability of online information on medicines. The variability in quality can be attributed to the recent shift toward digital information-seeking and the absence of specialized tools designed to assess the quality of medication-related information online.AimTo evaluate the quality of information about Amitriptyline available on websites using three well-established, generic evaluation tools—HONcode, DISCERN, and JAMA—compared against the domain-specific Keystone action plan criteria.MethodsAdopting an evaluative research design, this study utilized the aforementioned four assessment tools to collect and analyze data. Four independent assessors were recruited to evaluate the quality of the information on selected websites.ResultsA Google search using “Amitriptyline” identified 30 websites for the study sample. Reliability analysis using Cronbach’s alpha, the Inter-Class Correlation coefficient, and Kendall’s rank-order correlation coefficient revealed that the Keystone criteria demonstrated the highest internal consistency and reliability compared to DISCERN, HONcode, and JAMA.ConclusionThis study indicates that the Keystone action plan criteria may serve as a reliable, domain-specific tool for evaluating medicines information on websites. The results underscore the importance of specialized assessment criteria for online medication information, as they provide more consistent and accurate evaluations compared to generic tools.