bluuebunny/crossref_metadata_2025_split huggingface dataset:
LTCC-based broadband double-channel NMR coil with a split-spiral geometry
Authors: Liang Jianyi , Davoodi Hossein , Chau-Nguyen Khai , Badililta Vlad , Korvink Jan 
Published: January 2025

Abstract

In the field of nuclear magnetic resonance (NMR), planar spiral detector coils have been exploited for their ease of fabrication with a high tolerance for accommodating flat samples and for the ability to be integrated with microfluidic systems. Additionally, recent studies demonstrated the feasibility of designing such micro planar spirals for broadband operation1,2. Here we explore a novel embodiment of the planar spiral with a third contact added at an intermediary position of the spiral track, which acts as a double-channel NMR detector. The spiral geometry was optimized through simulation so that the inner loop and the full loop correspond to two frequency bands of interest. With the combined microfluidic and NMR devices fabricated for the first time in low-temperature cofired ceramic (LTCC) technology, we demonstrate untuned broadband operation by presenting 1D NMR spectra of 4 isotopes from 125MHz to 500MHz, as well as 2D 1H-13C HSQC measurements. The design is easy to use and shows high robustness, demonstrating potential for NMR studies of flow systems with multiple nuclei.
Bigatti shaver versus Bipolar electrocautry in management of endometrial polyps in infertile women
Authors: -Hassan Raya Muslim Al 
Published: January 2025

Abstract

Background:
Endometrial polyps may be characterized by heavy vaginal bleeding which needs surgical interventions like bipolar electrocautry surgery. They are commonly removed by excision using a resectoscope but this approach convey several complications like lack of complete removal, improper imaging , fluid intolerance and uterine or bowel injury .The new intrauterine Bigatti shaver (IBS) is a mechanical shaver that provides complete resection ,continuous fluid Input and deficit ,direct visualization and rare recurrence .Aim: To assess the intrauterine Bigatti shaver safety and value as hysteroscopic mechanical removal procedure for the management of endometrial polyps in comparison with resectoscope hysteroscopy.
Methods:.
The study was performed between October 2023 to October 2024 on sixty patients .All
demographics and operative information like set-up time, resection time and complications
were evaluated ,endometrial polyps were removed by two procedures, Bigatti shaver and resectoscope hysteroscopy .data collected and analyzed .
Results:
Sixty patients were divided into 2 groups for Bigatti shaver and resectoscope hysteroscopy
.There is significant difference in operating time between Bigatti shaver and resectoscope (2.46 ± 0.65, 7.44 ± 1.08 respectively ), in addition to significant difference in fluid input(1108.06±250.03, 1803.45 ± 431.14 respectively ) but fluid defecits have no significant
differences. In Bigatti shaver all patients have no bleeding as a complication when compared to resectoscope .
Conclusion:
.. The Bigatti shaver is a highly effective tool for the removal of endometrial polyps, offering a minimally invasive alternative to traditional methods. It combines mechanical tissue resection with continuous visualization, reduces the risk of uterine perforation and minimizes trauma to surrounding tissue, promoting faster recovery and enhanced patient outcomes
Suvmax of the Lesion Should Be Considered in the Treatment Plan for Stage I Non-small Cell Lung Cancer
Authors: Kocaman Gökhan , Ibrahımov Farrukh , Kahya Yusuf , Araz Mine , Elhan Atilla Halil , Enön Serkan 
Published: January 2025

Abstract

Objectives: High maximum standardized uptake value (SUVmax) is associated with poorly differentiated tumors and lymph node metastasis.It is still controversial which tumors can be treated with sublobar resection and there are publications stating that SUVmax of the tumor may be important in choosing sublobar resection. Our aim in this study is to examine the prognostic value of tumor SUVmax in stage 1 non-small cell lung cancer and to determine its place in sublobar resection preference.
Methods: The study included 314 patients who underwent wedge resection, segmentectomy or lobectomy for pathological stage I NSCLC with tumor size ≤3 cm between January 2008 and December 2020. SUVmax of the tumors are dichotomized according to ROC threshold value 5.2 and prognostic factors for recurrence-free and overall survival were analysed.
Results: In the multivariate survival analysis, SUVmax (p=0.012), lymphovascular and/or perineural invasion (p<0.001) and visceral pleural invasion (p=0.031) were found to be independent prognostic factors for recurrence-free survival (Table 2); age (p=0.027), sex (p=0.010) and SUVmax (p=0.036) for overall survival. While there was no difference between lobar or sublobar resection in terms of recurrence-free survival (p=0.647) in patients with SUVmax ≤5.2, lobectomy was found to be advantageous over sublobar resection for recurrence-free survival in patients with SUVmax >5.2 (76.6%±3.9% / 53.4%±12.1%, p=0.006, respectively)
Conclusions: High SUVmax (>5.2) is associated with poor recurrence-free survival and overall survival rates in pathological stage 1 NSCLC patients. In stage 1 patients, sublobar resection should be avoided if the primary tumor has a high SUVmax.
Assessment of Gonadal Hormones levels in Iron Deficient Females of Reproductive Age
Authors: Bani-Ahmad Mohammad A. , Hashim Jood M. , Khawaldeh Alia S. , Al-Odat Ibrahim A. , Al-Fawaeir Saad A. , Ahmad Abdelraheem A. Bani , Nazazleh Hiba A. 
Published: January 2025

Abstract

Background
Iron deficiency is a common malnutritional disorder with a wide variety of systemic clinical outcomes, including endocrine dysfunction. This study is a randomized descriptive study that, primarily, aimed to investigate that impacts of iron deficiency on the serum levels of gonadal hormones levels among females on reproductive age. To achieve so, a total of one hundred and twenty-three Female were included and were categorized by the menstrual phase based on obtained information form included subjects. Furthermore, based on their serum iron levels, subjects were subcategorized into iron sufficient (IS) and iron deficient (ID) females. Serum levels of iron, ferritin, Follicle-stimulating factor (FSH), Luteinizing hormone (LH), Progesterone, and estrogen were measured.
Results
No remarkable change in serum hormones levels during the follicular phase. During midcycle phase, ID subjects had significantly lower LH (17.49 ± 1.14 vs. 45.22 ± 6.31 IU/L, P < 0.001) and higher progesterone (11.2 ± 3.5 nmol/L vs. 1.95 ± 0.4 nmol/L, P < 0.05). Though it was statistically insignificant, the average serum estrogen among ID subjects was 128.4 ± 14.9 IU/L as compared to 202.4 ± 52.5 IU/L among IS females, P = 0.212. Serum LH and progesterone were significantly associated with serum iron levels (0.581, P < 0.005 and − 0.481, P < 0.05, respectively). Among ID females on luteal phase, significantly higher serum levels of estrogen (170.6 ± 9.5 pg/mL vs. 121.1 ± 13.1 pg/mL, P < 0.005) and progesterone (43.9 ± 3.3 nmol/L vs. 28.0 ± 4.1 nmol/L, P < 0.01). Furthermore, they were significantly associated with serum iron (-0.421, P < 0.05 and − 0.400, P < 0.05, respectively).
Conclusion
our data offers initial insights into the dysregulatory impacts of iron deficiency on the dynamic balance of gonadal hormones via the disruption of the hypothalamic-pituitary-gonadal-axis. Considering the positive feedback interaction, the main findings are the reduced levels of LH and estrogen below the optimal levels, during the luteal phase, in the context of iron deficiency. The reported impaired or delayed LH surge during the midcycle may reveal clinical impacts of iron deficiency on fertility and ability to conceive among females on reproductive age. Further investigation is required to validate our findings on a larger sample size and multiple time-points measurements throughout the menstrual phases of study subjects.
Aluminum Redox Catalysis: Cyclotrimerization of Alkynes
Authors: Zhang Xin , Liu Liu Leo 
Published: January 2025

Abstract

Aluminum catalysis has conventionally been limited to exploiting the Lewis acidic properties of the metal in its +III oxidation state. Herein, we show a low-valent aluminum species, specifically carbazolylaluminylene, which is capable of undergoing oxidative addition, twofold insertion, isomerization and reductive elimination processes via an Al(I)/Al(III) redox cycle—mimicking the quintessential steps characteristic of transition metal catalysis. This innovation enables effective, regioselective Reppe cyclotrimerization of alkynes to form a variety of benzene derivatives, achieving the highest turnover number of 2290. Through X-ray crystallography and quantum chemical analyses, we reveal that the adaptable nitrogen geometry of the carbazolyl ligand modulates the coordination environments at aluminum, thereby facilitating the catalytic cycle. Our work provides insights for further design and application of catalysis based on the main group redox cycle.
Sodium-Glucose Cotransporter 2 Inhibitors and Changes in Epicardial
Adipose Tissue: A Systematic Literature Review And Meta-Analysis
Authors: Theofilis Panagiotis , Oikonomou Evangelos , Vlachakis Panayotis K. , Karakasis Paschalis , Dimitriadis Kyriakos , Sagris Marios , Pamporis Konstantinos , Drakopoulou Maria , Siasos Gerasimos , Tsioufis Konstantinos , Tousoulis Dimitris 
Published: January 2025

Introduction:
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have emerged as a
groundbreaking class of antidiabetic medications renowned for their glucose-lowering effects and
cardiovascular benefits. Recent studies have suggested that SGLT2 inhibitors may extend their influence
beyond glycemic control to impact adipose tissue physiology, particularly within the epicardial
adipose depot. Epicardial adipose tissue (EAT), an actively secretory organ surrounding the heart,
has been implicated in the modulation of cardiovascular risk.

Aims:
This systematic review and meta-analysis aims to systematically review and synthesize existing
literature on the effects of SGLT2 inhibitors on EAT.

Methods:
We performed a literature search for studies assessing the changes in epicardial adipose
tissue volume/thickness before and after treatment with an SGLT2 inhibitor. We excluded reviews,
editorials, case reports/case series, experimental studies, and studies that did not use SGLT2 inhibitors
as the intervention. The main outcome of interest was the change in EAT volume/thickness at
follow-up.

Results:
The literature search yielded 72 results. After the application of the exclusion criteria, a total
of 11 studies were selected for data extraction and inclusion in the meta-analysis. A mean of 6.57ml
decreased EAT volume, and EAT thickness was reduced by a mean of 1.55mm. We detected that
treatment with an SGLT2 inhibitor was associated with decreased EAT volume/thickness compared
to the control group (SMD -1.79, 95% CI -2.91 to -0.66, p<0.01). There was substantial betweenstudy
heterogeneity (I2: 94%, p<0.001). Results remained robust even after the exclusion of any single
study. Subgroup analysis revealed a significantly greater effect size in randomized studies. Funnel
plot inspection and Egger’s regression test did not indicate the presence of publication bias

Conclusion:
This meta-analysis suggests that SGLT2 inhibitors use is associated with a reduction in
EAT volume/thickness, posing as a potential mechanism of their beneficial effects in heart failure
(HF) outcomes.
Irisquinone's Anti-cancer Potential: Targeting TrxR to Trigger ROS-mediated
Apoptosis and Pyroptosis
Authors: Zhang Qifeng , Wang Xinyan , Tana Gegen , Liang Guodong , Ma Yuheng , Bu Ren , Ga Lu 
Published: January 2025

Background:
Irisquinone, an important compound extracted from Semen Irisis, has been used clinically
as a radiotherapy sensitizer for lung, oesophageal, head and neck, breast and leukemia cancers. However, the
mechanism by which it acts against cancer is still unclear.

Objective:
The present study aims to investigate the anti-tumor activity and mechanism of Irisquinone.

Methods:
The effect of Irisquinone on cell viability and proliferation was evaluated using the CCK-8 assay. Fluorescence
probe (Fast-TRFS) and DTNB assay were used to observe the inhibitory effect of Irisquinone on both
intracellular and extracellular thioredoxin reductase (TrxR). The level of reactive oxygen species (ROS) in tumor
cells was assessed using the DCFH-DA probe. Annexin V-FITC/PI, staining and microscopy experiments, were
used to examine the apoptosis and pyroptosis. Western blotting analyses confirmed that Irisquinone induced
apoptosis and pyroptosis in cancer cells by inhibiting TrxR to increase ROS generation

Results:
Our research has shown that Irisquinone has anti-proliferative effects on several cancer cell lines while
having low toxicity to normal cells. The amount of ROS induced by inhibition of TrxR activated the BAX (proapoptotic
protein) and caspase-1(the pro-pyroptotic protein) to induce apoptosis and pyroptosis.

Conclusion:
Irisquinone showed anticancer activity through inhibiting TrxR. These results suggested that Irisquinone
will be developed to be an anti-tumor drug possibility.
Combination Therapy of SGLT 2 Inhibitors and GLP 1 Receptor Agonists for Glycaemic Management through Weight Reduction
Authors: Kumar Vinod , Amulya V B , Sharma Manjari , Saikrupa B V 
Published: January 2025

A great deal of anti-diabetic drugs leads to weight gain, which could contribute to obesity and possibly both diabetes and obesity. Glucose-lowering medications that contain sodium-glucose co-transporter 2 (SGLT2) inhibitors work by preventing the kidneys from reabsorbing glucose and sodium, which causes glycosuria and lowers plasma glucose levels. Consequently, its effects include decreases in HbA1c, blood glucose levels, and blood pressure along with decline in body weight and adiposity. Consistently, people on medications that inhibit SGLT2 tend to lose weight, but this weight loss is only modest since opposing regulatory processes work to keep the body's weight constant. This has driven researchers to investigate the use of SGLT2 inhibitors in combination with other drugs that work by reducing appetite, such as glucagon-like peptide 1 receptor agonists (GLP1RAs). In a retrospective study at the Wolver Hampton Diabetes Centre, researchers evaluated the effectiveness of combination therapy using GLP-1 agonists and SGLT-2 inhibitors in the management of diabetes and obesity. Patients on the combined regimen showed statistically significant improvements in clinical measures like body weight reduction, glycated hemoglobin (HbA1c) reduction, lower BMI, and reduced insulin dose. Such combinations, which include SGLT2 inhibitors, are intriguing because of the bodyweight effects and the indications of protection of cardiovascular and renal problems. These results imply that combination therapy using GLP-1 agonists and SGLT-2 inhibitors offers individuals with diabetes and obesity a promising treatment choice
Keywords: Diabetes Mellitus, obesity, SGLT 2 inhibitors, GLP 1 receptor agonist.
Biological Activities and Mechanisms of Actions of Bioactive Compounds (BACS) Identified in Pure and Ternary Blends of Cocoyam, Soya Bean and Bambara Groundnut Flour Using Gas Chromatography-Mass Spectrometry (GC-MS) Technique: A Review
Authors: Uro-Chukwu Henry Chukwuemeka , Uro-Chukwu Franklyn Chidiebere , Uro-Chukwu Frances Chidinma 
Published: January 2025

Background: functional foods contain bioactive compounds (BACS) and can be sourced from both animals and plants like cocoyam (CY), soya bean (SB) and bambara groundnut (BGN). previous studies have reported various bacs in each of these plants but literature is scanty on the types and amount, of bacs in such flour blends and formulations. when in combinations as blend, anti-oxidant, interactions occur, resulting in either potentiation, additive, synergistic or antagonistic effect, depending on several various variables. their in-vivo bioactivities which are due to various structural features of the BACS, can be antioxidant, anti-inflammatory, hypocholestrolaemic, antimicrobial and anti-diabetic activities. in this review the various bacs identified by gas chromotagraphy (GC)-mass spectrometry (MS) technique in the various formulations of CY-SB-BGN flour blends were researched for their biological activities and reported mechanisms of actions.
Methodology: a google search of a study on bacs identified using gc-ms in cy-sb-bgn flour blend was conducted and one paper was identified. the bacs reported in the study was noted and literature search of the various biological activities of such compounds and their mechanisms of actions were conducted. the results were documented and discussed.
Results and Discussion: the study revealed that thiadiazole, stilbene, aziridine, thiourea, amphetamine/phenylethylene, artemisinin, monoterpenoids, naphthalenes, i,4-diazpanes, phenols and flavanoids were the identified bacs in cy-sb-bgn flour blend formulations with both the pure and ternary blends showing different family classifications of compounds and different types of compounds in one family class. the biological activities and mechanisms of actions included antimicrobial, antioxidant, antiinflammatory and antidiabetic activities with reported mechanisms of actions for each of these invivo activities.
Conclusion: there are bacs in cy-sb-bgn formulations which are reported from studies to possess anti-microbial, anti-inflammatory, anti-oxidant and anti-diabetic properties invivo, with very established mechanisms of actions, making the use of such plant foods in disease management scientific, hence the recommendation of such plant foods use as adjunct in chronic disease management.
Keywords: Bioactive compounds, Plant foods, Cocoyam, Soya Bean, Bambara Groundnut
FILSAFAT KEHENDAK SCHOPENHAUER DAN SIFAT QANA’AH SEBAGAI LANDASAN GAYA HIDUP MINIMALIS
Authors: Arifin Jainul , Sofyan Nurul Hikmah , Pujiono Imam Prayogo 
Published: January 2025

Consumerism often promises or measures one’s happiness through the ownership of things. In fact, the happiness obtained from material possessions is only temporary . This research aims to study how the theory of "abjuring willing” in Schopenhauer's philosophy and qana'ah in the perspective of Sufism can contribute to strengthening the basis of a minimalist lifestyle, the purpose to provide a new life orientation for individuals who are bored with the cultural orientation of consumerism. This type of research is qualitative library research where in analyzing the researcher uses an integrative analysis method namely an analysis from a philosophical and Sufism perspective according to the theory offered by the author in this article. Data collection uses documentation techniques taken from sources relevant to the research focus. The finding of this research is that the theory of "abjuring willing” by Schopenhauer and qana'ah can be a basis for individuals to strengthen the implementation of a minimalist lifestyle. From the theory of " abjuring willing", individuals can learn to reduce the desire to have more. Meanwhile, by instilling qana'ah within oneself, individuals will feel satisfied with what they have.
Adaptive Property Reuse for Social Housing: Benefits, Challenges, and Best Practices
Authors: Sanchaniya Rashmi Jaymin , Černeckienė Jurgita , Gudumasu Naga Shilpa , Kundziņa Antra 
Published: January 2025

Abstract
This study examines the adaptive reuse of properties for the development of social housing, focusing on the benefits, challenges, and best practices associated with this approach. Through a comprehensive literature review and analysis of case studies, the research investigates how adaptive reuse can address housing shortages while promoting sustainable urban development. The study identifies key economic, environmental, and social benefits of adaptive reuse in social housing, including cost savings, reduced environmental impact, and community revitalisation. It also explores the technical, financial, regulatory, and social challenges often arising in such projects. The research presents a detailed analysis of successful adaptive reuse case studies, highlighting effective strategies to overcome common obstacles. Based on these findings, the study proposes a set of best practices for planning, designing, and implementing adaptive reuse projects in social housing. The paper concludes with policy recommendations and suggestions for future research, highlighting the potential of adaptive reuse to contribute significantly to sustainable and inclusive urban housing solutions.
Benefits Of Omega-3 In Peruvian Anchoveta: A Review Of Its Impact On Health
Authors: Herrera- Cruz Jorge Patrocinio , Castro- Rojas Miriam , Cornejo Rodolfo , Delgado -Flores Hilda , Minaya- Agüero Carmen del Pilar , Martínez- Albán Pascual Alejandro , Zúñiga- Vargas Oscar Alberto 
Published: January 2025

Objectives: The objective of the research was to analyze the current state of knowledge about Omega-3 in the Peruvian anchovy to understand its positive effects on health and promote its adequate consumption.

Theoretical framework: The Omega-3 fatty acid present in the Peruvian anchovy is widely known by the scientific community, but its information has not been disseminated enough to know its positive effects in the treatment of inflammatory and autoimmune diseases.

Method: The positive effects of Omega-3 fatty acid on health were explored from various perspectives, highlighting its anti-inflammatory action and potential in the prevention and treatment of chronic diseases.

Results and discussion: The anchovy, abundant in the Peruvian sea and economic for its availability of catch by the fishing fleet, offers an accessible alternative without compromising the nutritional content, especially relevant in regions with low economy where other sources of Omega-3 are unreachable. It is concluded that anchovy is an accessible source of Omega-3 with considerable nutritional and economic value. Consumption improves public health by preventing chronic and autoimmune diseases.

Implications of research: Promote public health policies that include anchovy to maximize its benefits to society, especially in vulnerable populations by ensuring food security and access to low-cost animal protein.

Originality/Value: It is essential to promote public health policies that include anchovy in accordance with the ecosystem approach applied to fisheries, food security and sustainable development goals. a rethinking of dietary recommendations is suggested, especially in vulnerable populations in Peru.