bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biphasic bone graft substitute in revision total hip arthroplasty with significant acetabular bone defects
Authors: McPherson Edward J. , Stavrakis Alexandra I. , Chowdhry Madhav , Curtin Nora L. , Dipane Matthew V. , Crawford Brooke M. 
Published: December 2022

Aims Large acetabular bone defects encountered in revision total hip arthroplasty (THA) are challenging to restore. Metal constructs for structural support are combined with bone graft materials for restoration. Autograft is restricted due to limited volume, and allogenic grafts have downsides including cost, availability, and operative processing. Bone graft substitutes (BGS) are an attractive alternative if they can demonstrate positive remodelling. One potential product is a biphasic injectable mixture (Cerament) that combines a fast-resorbing material (calcium sulphate) with the highly osteoconductive material hydroxyapatite. This study reviews the application of this biomaterial in large acetabular defects. Methods We performed a retrospective review at a single institution of patients undergoing revision THA by a single surgeon. We identified 49 consecutive patients with large acetabular defects where the biphasic BGS was applied, with no other products added to the BGS. After placement of metallic acetabular implants, the BGS was injected into the remaining bone defects surrounding the new implants. Patients were followed and monitored for functional outcome scores, implant fixation, radiological graft site remodelling, and revision failures. Results Mean follow-up was 39.5 months (36 to 71), with a significant improvement in post-revision function compared to preoperative function. Graft site remodelling was rated radiologically as moderate in 31 hips (63%) and strong in 12 hips (24%). There were no cases of complete graft site dissolution. No acetabular loosening was identified. None of the patients developed clinically significant heterotopic ossification. There were twelve reoperations: six patients developed post-revision infections, three experienced dislocations, two sustained periprosthetic femur fractures, and one subject had femoral component aseptic loosening. Conclusion Our series reports bone defect restoration with the sole use of a biphasic injectable BGS in the periacetabular region. We did not observe significant graft dissolution. We emphasize that successful graft site remodelling requires meticulous recipient site preparation. Cite this article: Bone Jt Open 2022;3(12):991–997.
IDENTIDADE FRÁGIL
Authors: Kreibich Susiane 
Published: December 2022

Resenha:
RICOEUR, Paul. Identidade Frágil: Respeito ao outro e identidade cultural.
Texto publicado em Os direitos da pessoa em questão, Europe Europa 2000, publicação FIACAT.
Tradução de Douglas Carré, Claudia Tiellet e Noeli Dutra Rossatto, publicada em Saber Humano, v. 10, n. 17, p. 7-15, jul/dez. 2020. (ISSN 2446-6298).
Industrial Revolution 4.0 and its impact on the evolution of the firm’s organization and management
Authors: Kora Holta , Beluli Rajmonda 
Published: December 2022

Fourth Industrial Revolution or Industry 4.0 refers to the evolution of industries, particularly in the manufacturing and chain production areas. Executive managerial decisions this industry have a substantial impact on technology, data management and analytics, data security, risk management, regulatory compliance, validation, and human resource practices, among other things. Artificial Intelligence, sensors, enterprise-level solution platforms, and Machine Learning will all be used extensively in the fourth industrial revolution. In industry 4.0, the volume of external and internal Internet of Things (IoT) data is expected to expand, resulting in a drastic shift in information.
The IR4.0 will result in an abundance of data flowing to quality experts in real-time, and this data will come from various sources at the same time, necessitating intelligent utilization to enable quick and effective decision-making. Managers and quality control employees must make the necessary decisions to provide a smooth transition to digital technology, which will increase the efficiency and quality of manufactured goods and services. Companies will be required to employ effective risk management strategies as part of the fourth industrial revolution in order to improve product quality and operational efficiency by allowing machine learning and Artificial Intelligence to give the finest services. As a result, the risk management team must develop plans to ensure that these tactics are implemented properly.
Furthermore, quality managers must ensure that Quality 4.0, which will coincide with the fourth industrial revolution, is implemented effectively. Previous research into how Industry 4.0 affects managerial decisions has been lacking and unsatisfactory. As a result, the article tries to provide a complete assessment of the fourth industrial revolution’s management implications.
Remote teaching and research of tax law during the COVID-19 pandemic: side reflections
Authors: Parente Salvatore 
Published: December 2022

The pandemic emergency from COVID-19, an unexpected and dramatic event, alongside the effects of a health, economic and social nature, has had repercussions on teaching and research activities at university level. The essay sets out some reflections on the meaning and quality of the teaching and research functions at a distance and in hybrid mode, in the context of tax law, in a perspective of sharing and “cross-fertilization”.
A novel histopathological classification of implant periapical lesion: A systematic review and treatment decision tree
Authors: Gong Jiaming , Zhao Ruimin , Yu Zhanhai , Li Jianxue , Mei Mei 
Published: December 2022

Background
Implant periapical lesion (IPL), as a peri-implant disease originating from implant apex, maintains coronal osseointegration in the early stage. With the understanding to IPL increasingly deepened, IPL classification based on different elements was proposed although there still lacks an overall classification system. This study, aiming to systematically integrate the available data published in the literature on IPL associated with histopathology, proposed a comprehensive classification framework and treatment decision tree for IPL.

Methods and findings
English articles on the topic of “implant periapical lesion”, “retrograde peri-implantitis” and “apical peri-implantitis” were searched on PubMed, Embase and Web of Science from 1992 to 2021, and citation retrieval was performed for critical articles. Definite histopathology and radiology of IPL are indispensable criteria for including the article in the literature. The protocol was registered in PROSPERO (CRD42022378001). A total of 509 papers identified, 28 studies were included in this review. In only one retrospective study, 37 of 39 IPL were reported to be at the inflammatory or abscess stage. 27 cases (37 implants) were reported, including acute non-suppurative (1/37, developed to chronic granuloma), chronic granuloma (5/37), acute suppurated (2/37), chronic suppurated-fistulized (6/37), implant periapical cyst (21/37), poor bone healing (2/37), foreign body reaction (1/37). Antibiotics alone did not appear to be effective, and the consequence of surgical debridement required cautious interpretation because of the heterogeneity of lesion course and operation. Implant apicoectomy and marsupialization were predictable approaches in some cases.

Conclusions
The diversiform nature of IPL in the case reports confirms the need for such histopathological classification, which may enhance the comparison and management of different category.
Delirium in hospitalized COVID-19 patients: Predictors and implications for patient outcome
Authors: Wilke Vera , Sulyok Mihaly , Stefanou Maria-Ioanna , Richter Vivien , Bender Benjamin , Ernemann Ulrike , Ziemann Ulf , Malek Nisar , Kienzle Katharina , Klein Constantin , Bunk Stefanie , Goepel Siri , Mengel Annerose 
Published: December 2022

Introduction
Delirium is recognized as a severe complication of coronavirus-disease-2019 (COVID-19). COVID-19-associated delirium has been linked to worse patient outcomes and is considered to be of multifactorial origin. Here we sought to evaluate the incidence and risk factors of delirium in hospitalized COVID-19 patients, along with its impact on clinical outcome.

Methods
Consecutive adult COVID-19 patients admitted to a tertiary academic referral hospital between March 1st and December 31st, 2020 were included. Potential risk factors for delirium were evaluated, including: age, gender, disease severity (as per the highest WHO grading reached during admission), laboratory parameters for infection and renal function (as per their most extreme values), and presence of comorbidities. To assess the relative strength of risk factors for predicting the occurrence of delirium, we performed a random-forest survival analysis.

Results
347 patients with positive COVID-19 PCR test and median age 68.2 [IQR 55.5, 80.5] years were included. Of those, 79 patients (22.8%) developed delirium, 81 (23.3%) were transferred to ICU, 58 (16.7%) died. 163 (73.8%) patients were discharged home, 13 (5.9%) to another hospital, 32 (14.5%) to nursing homes, 13 (5.9%) to rehabilitation with an overall median admission-to-discharge time of 53 [IQR 14, 195] days. The strongest predictors for the occurrence of delirium were blood urea nitrogen (minimal depth value (MD): 3.33), age (MD: 3.75), disease severity (as captured by WHO grading; MD: 3.93), leukocyte count (MD: 4.22), the presence of a neurodegenerative history (MD: 4.43), ferritin (MD: 4.46) and creatinine (MD: 4.59) levels.

Conclusion
The risk of delirium in COVID-19 can be stratified based on COVID-19 disease severity and–similar to delirium associated with other respiratory infections–the factors advanced age, neurodegenerative disease history, and presence of elevated infection and renal-retention parameters. Screening for these risk factors may facilitate early identification of patients at high-risk for COVID-19-associated delirium.
Pharmaceutical care program for patients with chronic kidney disease in the community pharmacy: Detection of nephrotoxic drugs and dose adjustment. Viability study
Authors: Escribá-Martí Gema , Cámara-Ramos Iker , Climent-Catalá María Teresa , Escudero-Quesada Verónica , Salar-Ibáñez Luis 
Published: December 2022

Introduction
Chronic kidney disease (CKD) is a major health problem. Early detection is the key to reducing morbidity and mortality, but it is difficult because it occurs without symptoms. Diagnosis of CKD is also important to avoid nephrotoxic drugs and to adjust the doses of other medications that may be affected. Pharmacies, due to their proximity to the population, frequency of patient visits, and knowledge of medication use are an ideal location for point-of-care diagnosis or CKD.

Objective
To detect and refer to the primary care physician patients with low estimated glomerular filtration rate (eGFR) who use nephrotoxic drugs or who may require a dose adjustment.

Methodology
Pharmacy users over 60 years of age who agreed to participate were given a creatinine/eGFR test with a point-of-care meter. The eGFR was calculated and if it was less than 60 ml/min/1.73 m2, their medications were evaluated to identify nephrotoxic drugs or drugs that potentially required adjustment. If either were found, they were referred to their doctor for further management.

Results
198 patients were recruited in 4 pharmacies, of which 87 (43.9%) had an eGFR less than 60 ml/min/1.73 m2. They were taking a total of 635 medications. Of these 635 medications, 50 (7.9%) were affected by kidney function. Dose adjustment was recommended in 31 and discontinuation in 19. The primary care doctor accepted the recommendations for 14 medications: dose adjustment for 6 and withdrawal in 8. This represents 2.3% of medications taken by patients with an eGFR less than 60 ml/min/1.73 m2. The 50 medications identified were taken by 29 patients (33.3% of the 87 with a low eGFR) and a change in treatment was generated in 9 patients, representing 4.6% of the total number of patients in the sample, and 10% of the patients with a low eGFR.

Conclusion
Point-of-care testing for kidney function in a pharmacy setting is feasible and identifies a significant number of patients with eGFR under 60 ml/min/1.73 m2. It also allows for appropriate medication management recommendations in this patient group.
Childhood sexual abuse, alcohol and drug use problems among Black sexual minority men in six US Cities: Findings from the HPTN 061 study
Authors: Shangani Sylvia , van den Berg Jacob J. , Dyer Typhanye V. , Mayer Kenneth H. , Operario Don 
Published: December 2022

Background
Prior research has found a high prevalence of childhood sexual abuse (CSA) among sexual minority men (SMM) in the US, and has indicated that CSA is associated with higher rates of alcohol and drug use disorders. However, most of these studies have focused almost exclusively on White SMM. We assessed associations of CSA, alcohol use, and drug use problems among adult Black SMM.

Methods
Participants were 1,016 Black SMM recruited from six US cities (Atlanta, Boston, Los Angeles, New York City, San Francisco, and Washington, DC) between July 2009 and December 2011. We used hierarchical logistic regression to evaluate the associations between CSA, alcohol use problems (≥ 8 AUDIT), and drug use problems (excluding marijuana).

Results
Mean (SD) age was 37.8 (11.7) years, and 28.6% and 49.2% reported alcohol and drug use disorders in the past six months, respectively. Most of the study participants reported history of CSA (70.3%). Adjusting for sociodemographic and confounding variables, CSA was associated with higher odds of alcohol use problems (odds ratio (OR) = 1.52, 95% CI 1.09, 2.12) and drug use problems (OR = 1.58, 95% CI 1.19, 2.10) than non-CSA group.

Conclusion
Prevalence of CSA is high among BSMM in the US and is positively associated with alcohol and drug use problems. Substance use interventions should address the psychological health needs of BSMM with a history of CSA.
Preliminary validation of the Chinese version of the Shame and Stigma Scale among patients with facial disfigurement from nasopharyngeal carcinoma
Authors: Cai Yuqi , Zhang Yuan , Cao Wangnan , Hou Fengsu , Xin Meiqi , Guo Vivian Yawei , Deng Yang , Wang Shenghao , You Xinyi , Li Jinghua 
Published: December 2022

Objective
This study examined the reliability and validity of a Shame and Stigma Scale (SSS) and assessed shame and stigma among patients with facial disfigurement from nasopharyngeal carcinoma (NPC).

Methods
Data were collected from 218 patients with NPC through a cross-sectional survey between January 14, 2020, and December 1, 2020. The original SSS is a 20-item scale with four dimensions (i.e., shame with appearance, sense of stigma, regret, and social/speech concern). We used Cronbach’s alpha and McDonald’s omega to assess reliability and exploratory factor analysis (EFA) to assess the factor structure. We also used Pearson correlation analysis to examine the relationship between each item and total score of scale items and convergent validity.

Results
The final 18-item SSS had a Cronbach’s alpha coefficient of .89. The EFA revealed that the SSS has a four-factor structure: sense of stigma, social/speech concern, shame with appearance, and regret. These factors showed satisfactory reliability, with McDonald’s omega coefficients of .87, .77, .86, and .79, respectively. The scale showed significant relationship between each item and total score of scale items with respect to item–total correlations, item–subscale correlations, and item–other-subscale correlations. Convergent validity was supported by the significant positively correlated with the total scores for depression and anxiety.

Conclusion
The SSS is valid and reliable in assessing shame and stigma and monitoring treatment compliance among patients with NPC.
An exploration of under-registration of chronic kidney disease stages 3–5 in Belgian general practices using logistic regression
Authors: Van den Wyngaert Ine , Mamouris Pavlos , Vaes Bert , Van Pottelbergh Gijs 
Published: December 2022

Background
Early detection and treatment of chronic kidney disease (CKD) can prevent further deterioration and complications. Previous studies suggested that the diagnosis is often made when advanced renal failure occurs. The aims of this study were to describe the prevalence of unregistered CKD stages 3–5 in a Belgian General Practitioner population, to determine risk factors for under-registration and to investigate the diagnostic delay.

Methods
The analyses were carried out in the INTEGO database, a Flanders general practice-based morbidity registration network. The study used INTEGO data from the year 2018 for all patients ≥18 years old. CKD was defined as two consecutive eGFR laboratory measurements (eGFR <60 mL/min/1.73m2) at least three months apart during the baseline period. Registered CKD was characterised by a documented diagnosis of CKD (ICPC2 U99) during the ≥12-month lookback period before the first eGFR measurement and up to six months after the second eGFR in the EHR. The prevalence of unregistered CKD and the median time of diagnostic delay were estimated. Baseline characteristics were described. A multivariate cross-sectional logistic regression analysis was conducted to identify determinants of unregistered CKD. We estimated the odds ratios and their 95% confidence interval.

Results
Among included patients, there were 10 551 patients (5.5%) meeting the criteria of CKD. The prevalence of unregistered CKD was 68%. The mean diagnostic delay was 1.94 years (Standard deviation 0.93). Being a male, a concurrent diagnosis of diabetes, stroke, heart failure and hypertension, and more severe CKD (stages 3b, 4 and 5) independently increased the chance on registered CKD.

Conclusion
The proportion of patients who had no registered CKD code in the EHR was substantial. The differences between registered and unregistered patients make thinking about solutions to facilitate registration in the EHR imperative.
Effectiveness of brief mindfulness intervention for college students’ problematic smartphone use: The mediating role of self-control
Authors: Liu Fengbo , Zhang Zhongqiu , Liu Shuqiang , Feng Zhantao 
Published: December 2022

Background
Mainland China has the most smartphone users worldwide, especially among college students, while mindfulness intervention can significantly alleviate the level of problematic smartphone use. We examined the effects of a brief mindfulness intervention on problematic smartphone use and investigated if this effect is mediated by self-control.

Methods
Participants were recruited randomly from a university in Beijing of China. Forty-four college students were assigned to a mindfulness group or a control group. The mindfulness group took part in a brief (30 min) single-session mindfulness intervention. The control group was instructed to listen to a neutral news audio recording for the same duration (30 min). The Freiburg Mindfulness Inventory, Mobile Phone Addiction Tendency Scale, and Self-control Scale were used to measure state mindfulness, problematic smartphone use, and self-control of college students at pre-intervention and post-intervention, respectively.

Results
Two-way repeated-measures ANOVA revealed that the mindfulness group had significant improvements in state mindfulness (p = .049) and self-control (p = .012), and had significant alleviation in problematic smartphone use (p < .001) at post-intervention. In the regression model, self-control had a mediating effect between mindfulness intervention and problematic smartphone use (95% CI [0.490, 7.216]).

Conclusions
A brief single-session mindfulness intervention can alleviate the level of problematic smartphone use and increase the level of state mindfulness and self-control compared to the control group. Self-control can completely mediate the efficacy of the mindfulness intervention in reducing problematic smartphone use.
O papel da microbiota intestinal nos transtornos depressivos: uma revisão sobre o tema e estudos clínicos
Authors: Kasprowicz Julia Nahir , Savi Daiani Cristina 
Published: December 2022

A ligação direta do eixo intestino-cérebro é cada vez mais debatida como um fator importante no desenvolvimento das doenças mentais, principalmente no transtorno depressivo maior. Há um eixo de comunicação bidirecional entre cérebro e intestino, onde anormalidades na microbiota intestinal afetam o cérebro e o comportamento. Neste sentido, as perturbações na microbiota intestinal, que favorecem a disbiose, são consideradas fator de risco chave para o transtorno depressivo, e a regulação desta é um método de terapia e prevenção da depressão. O presente estudo analisou o impacto do tratamento com probióticos no desenvolvimento do transtorno depressivo maior, por meio de uma revisão bibliográfica integrativa de estudos clínicos publicados nos últimos 5 anos. Ao total, foram selecionados 8 artigos, nos quais as bactérias estudadas pertencem aos gêneros Bifidobacterium, Lactobacillus e Lactococcus. Os artigos apontam que a intervenção com probióticos atua no transtorno depressivo maior por três mecanismos de ação. Referindo-se a produção de ácidos graxos de cadeia curta, reduzindo o pH intestinal e retardando o crescimento de bactérias patogênicas. Promovendo a síntese de IgA a qual protege a barreira intestinal, impedindo a passagem de LPS para a circulação, diminuindo a inflamação sistêmica. Por fim, através do aumento dos níveis plasmáticos de triptofano e a diminuição da concentração de quinurenina, consequentemente melhorando a produção de serotonina. Assim, o cuidado com a microbiota intestinal e o uso de probióticos pode auxiliar no tratamento de transtornos depressivos e também na prevenção, atuando como uma nova opção terapêutica.
Religiusitas Guru PAI: Upaya Peningkatan Disiplin Beribadah Siswa di SMP Islam Al Azhar 3 Bintaro
Authors: Rokhmah Dewi 
Published: December 2022

PAI Teacher Religiosity: Efforts to Improve the Discipline of Student Worship at Al Azhar 3 Bintaro Islamic Junior High School.
The purpose of this study was to determine the role of PAI teacher religiosity in an effort to increase the discipline of student worship at SMP Islam Al Azhar 3 Bintaro. Sources of data in this study were school heads, Islamic education teachers, and students. The technique of collecting data was done by means of interviews, observation, and documentation. The data obtained were analyzed using four steps, namely data collection, data reduction, data presentation, and verification or drawing conclusions. The results of this study indicate that the religiosity of PAI teachers at SMP Islam Al Azhar 3 Bintaro plays a role in increasing student discipline in worship characterized by congregational prayer, tahfdiz Quran, and tadarus which are routinely carried out properly and correctly. The application of PAI teacher religiosity in an effort to increase the discipline of student worship by providing motivation and exemplary.