bluuebunny/crossref_metadata_2025_split huggingface dataset:
The therapeutic targets of N6-methyladenosine (m6A) modifications on tumor radioresistance
Authors: Zhang Yi , Gu Wendong , Shao Yingjie 
Published: July 2023

AbstractRadiation therapy is an important tool for malignant tumors, and its tolerance needs to be addressed. In recent years, several studies have shown that regulators of aberrant m6A methylation play an important role in the formation, development and invasion and metastasis of tumors. A large number of studies have confirmed aberrant m6A methylation as a new target for tumour therapy, but research on whether it can play a role in tumor sensitivity to radiotherapy has not been extensive and thorough enough. Recent studies have shown that all three major enzymes of m6A methylation have significant roles in radioresistance, and that the enzymes that play a role differ in different tumor types and by different mechanisms, including regulating tumor cell stemness, affecting DNA damage and repair, and controlling the cell cycle. Therefore, elucidating the mechanisms of m6A methylation in the radiotherapy of malignant tumors is essential to counteract radioresistance, improve the efficacy of radiotherapy, and even propose targeted treatment plans for specific tumors. The latest research progress on m6A methylation and radioresistance is reviewed in this article.
Uncertainty quantification for mineral precipitation and dissolution in fractured porous media
Authors: Botti Michele , Fumagalli Alessio , Scotti Anna 
Published: July 2023

AbstractIn this work we present an uncertainty quantification analysis to determine the influence and importance of some physical parameters in a reactive transport model in fractured porous media. An accurate description of flow and transport in the fractures is key to obtain reliable simulations, however, fractures geometry and physical characteristics pose several challenges from both the modeling and implementation side. We adopt a mixed-dimensional approximation, where fractures and their intersections are represented as objects of lower dimension. To simplify the presentation, we consider only two chemical species: one solute, transported by water, and one precipitate attached to the solid skeleton. A global sensitivity analysis to uncertain input data is performed exploiting the Polynomial Chaos expansion along with spectral projection methods on sparse grids.
Ring of Hope: A Novice’s Experience in a Cancer Centre
Authors: Shah Muhammad Hamza 
Published: July 2023

AbstractThe ringing of a bell has become an honored and cherished tradition in the realm of cancer survivorship care. As a medical student, I was initially unaware of this practice, but I have since gained a profound appreciation for its deep significance and emotional potency. Through the act of ringing the bell, patients who have successfully completed their cancer treatment are able to mark the end of a gruelling journey, while also heralding the start of a new and hopeful chapter in their lives.
Assessment of water quality using multivariate statistics and geographical information systems (GIS) of Wadi Aldabab, Taiz, Yemen
Authors: AL-Areeq Ahmed M. , Chowdhury Shakhawat , Rahman Muhammad T. , AL-Areeq Nabil M. , Quriaa Hadi 
Published: July 2023

AbstractThe shortage of water resources in Yemen has an implication on the availability and supply of safe water in the country. This study assessed the water quality in Wadi Al-Dabab, Taiz, Yemen. Water samples were collected from the springs and different types of wells (tube, manual) with depths ranging from 9 to 500 m. Multivariate statistical analysis was performed on 15 water quality parameters (WQP) from 15 locations to investigate the significant WQP and the possibility of data reduction. The water quality index (WQI) approach was used to assess its suitability for drinking purposes. Four principal components were identified to be significant, which explained 86.2% of the overall variance while four varifactors (VF) explained 80% of the data variance. The findings showed the possibility of data reduction by 20%, which could assist in water quality monitoring at a reduced cost. The WQI map shows that the water quality is good in a limited area and poor to very poor in most of the study area. The findings are likely to assist in identifying the important WQP for the protection of the drinking water sources while the less important WQP can be excluded, which might reduce the cost of water quality monitoring. The proposed approach is likely to be a cost-effective approach for the economically weak and water-stressed countries, which can contribute positively for the sustainable water resource management in Yemen and other water-stressed regions.
A statistical assessment of the fatigue strength improvement of butt-welded joints by flush grinding
Authors: Braun Moritz , Baumgartner Jörg , Hofmann Gloria , Drebenstedt Karl , Bauer Niklas Michael , Bakhschi Hadi , Kuhlmann Ulrike 
Published: July 2023

AbstractAll major rules and guidelines include fatigue design (FAT) classes for flush ground butt-welded joints. These FAT classes vary between FAT110 and FAT155; however, in the majority of cases, the underlying database and specimen-related details are unclear or unknown. This study evaluates 1003 fatigue test results gathered from various literature sources and tries to relate the fatigue strength improvement to typical specimen types and test conditions. To this goal, statistical methods based on correlation analysis are employed. Next, proposals for updates of rules and guidelines for flush ground butt-welded joints made of steel are established by determining new FAT classes and a suitable slope exponent. In addition, an overview of design standards and recommendations is given and main influencing factors are discussed.
Fedlabx: a practical and privacy-preserving framework for federated learning
Authors: Yan Yuping , Kamel Mohammed B. M. , Zoltay Marcell , Gál Marcell , Hollós Roland , Jin Yaochu , Péter Ligeti , Tényi Ákos 
Published: July 2023

Abstract
Federated learning (FL) draws attention in academia and industry due to its privacy-preserving capability in training machine learning models. However, there are still some critical security attacks and vulnerabilities, including gradients leakage and interference attacks. Meanwhile, communication is another bottleneck in basic FL schemes since large-scale FL parameter transmission leads to inefficient communication, latency, and slower learning processes. To overcome these shortcomings, different communication efficiency strategies and privacy-preserving cryptographic techniques have been proposed. However, a single method can only partially resist privacy attacks. This paper presents a practical, privacy-preserving scheme combining cryptographic techniques and communication networking solutions. We implement Kafka for message distribution, the Diffie–Hellman scheme for secure server aggregation, and gradient differential privacy for interference attack prevention. The proposed approach maintains training efficiency while being able to addressing gradients leakage problems and interference attacks. Meanwhile, the implementation of Kafka and Zookeeper provides asynchronous communication and anonymous authenticated computation with role-based access controls. Finally, we prove the privacy-preserving properties of the proposed solution via security analysis and empirically demonstrate its efficiency and practicality.
Rule of Law Through the ‘Urban Turn’ in South African Constitutionalism
Authors: Pieterse Marius 
Published: July 2023

AbstractThe 1996 South African Constitution transformed municipalities from creatures of statute into an interdependent sphere of government, thereby enabling South African cities to carve out a space for autonomous urban governance, which is closely associated with the progressive realisation of socio-economic rights. This article considers how South African courts have deployed, reconfigured and channelled the rule of law in intergovernmental relations disputes, disputes concerning the developmental obligations of local government and socio-economic rights disputes, in order to fortify urban autonomy, to substantively guide its exercise and to ensure dynamic accountability for urban local governments’ role in ensuring the progressive realisation of socio-economic rights.
Solvable models of quantum black holes: a review on Jackiw–Teitelboim gravity
Authors: Mertens Thomas G. , Turiaci Gustavo J. 
Published: July 2023

AbstractWe review recent developments in Jackiw–Teitelboim gravity. This is a simple solvable model of quantum gravity in two dimensions (that arises e.g. from the s-wave sector of higher dimensional gravity systems with spherical symmetry). Due to its solvability, it has proven to be a fruitful toy model to analyze important questions such as the relation between black holes and chaos, the role of wormholes in black hole physics and holography, and the way in which information that falls into a black hole can be recovered.
Optical and electrical evaluation of a nylon 11-ZnO film incorporation in disodium phthalocyanine heterostructures
Authors: Hamui Leon , Vergara María Elena Sánchez , Sánchez Mauricio Riestra 
Published: July 2023

AbstractDisodium phthalocyanine (Na2Pc) has been considered as promising organic semiconductor for optoelectronic applications, however, Na2Pc-based devices are not being fully studied. To study the Na2Pc as active layer for optoelectronic devices, and also the effect of the incorporation of a nylon 11-ZnO film within the device heterostructure, in this work two heterojunction cells of Ag/Na2Pc + TCNQ/triphenylamine/p-Si/Al and Ag/nylon 11-ZnO/Na2Pc + TCNQ/triphenylamine/p-Si/Al were fabricated by vacuum thermal evaporation technique. The topography of the heterostructures was analyzed by atomic force microscopy. Later, the films that form the heterostructure were optically characterized by Ultraviolet-visible spectroscopy and the optical band gap and the Urbach energy were obtained. The values of the optical gap for the films are between 2.08 and 2.93 eV. The value of Urbach energy is lower for the pristine triphenylamine film, and higher for the film composed of nylon and ZnO. Moreover, the two heterostructures present a strong photoluminescence in the visible region. On other hand, by introducing the nylon 11-ZnO film in the heterostructure shows an important increase of the short circuit current density (Jsc), conductivity and photocurrent values, indicative of a better mobility and more carriers generation. For this heterostructure a mean 79.7% external quantum efficiency and 0.48 mA/cm2 Jsc were obtained. These results indicate that these heterostructures can be used toward organic solar cell applications and remark on the large effect of the nylon 11-ZnO dielectric film addition on their performance.
A Blade Altering Toolbox for Automating Rotor Design Optimization
Authors: Wernick Akiva , Chen Jen-Ping 
Published: July 2023

AbstractThe Blade Altering Toolbox (BAT) described in this paper is a tool designed for fast reconstruction of an altered blade geometry for design optimization purposes. The BAT algorithm is capable of twisting a given rotor’s angle of attack and stretching the chord length along the span of the rotor. Several test cases were run using the BAT’s algorithm. The BAT code’s twisting, stretching, and mesh reconstruction capabilities proved to be able to handle reasonably large geometric alterations to a provided input rotor geometry. The test examples showed that the toolbox’s algorithm could handle any stretching of the blade’s chord as long as the blade remained within the original bounds of the unaltered mesh. The algorithm appears to fail when the net twist angle applied the geometry exceeds approximately 30 degrees, however this limitation is dependent on the initial geometry and other input parameters. Overall, the algorithm is a very powerful tool for automating a design optimization procedure.
Hierarchically porous N-doped carbon framework with enlarged interlayer spacing as dual-carbon electrodes for potassium ion hybrid capacitors
Authors: Gao Qingchao , Li Tuo , Liu Chanjuan , Sun Jinfeng , Liu Yang , Hou Linrui , Yuan Changzhou 
Published: July 2023

AbstractThanks to the high power/energy densities together with lower cost, potassium ion hybrid capacitors (PIHCs) have broad application prospects. Nevertheless, the significant volume changes during K+ intercalation/deintercalation together with the misfit between anode as well as cathode limit their further development. Herein, hierarchically porous nitrogen-doped carbon (N-HPC) is fabricated and used as two electrodes materials for PIHCs. The three-dimensional hierarchical porous structure and large interlayer distance of N-HPC afford enough space to alleviate the volume expansion of potassium. Furthermore, the suitable N doping enables additional active sites towards K+ storage and improves electrical conductivity of electrodes. Hence, the constructed PIHCs assembled with dual N-HPC electrodes deliver a high energy density of 103.5 Wh kg‒1 at 1000.0 W kg‒1. Meanwhile, the PIHCs devices also display superior cycling stability, achieving a capacity retention rate of 70.2% after 10,000 cycles at 1.0 A g‒1.
Graphical Abstract
Hierarchically porous nitrogen-doped carbon (N-HPC) is fabricated and used as two electrode materials for PIHCs. The three-dimensional porous structure of N-HPC, the larger inter-layer distance, and the synergy of N-doped introduction of more active sites make it have good magnification properties. At the same time, the assembled PIHCs cycle of 10000 laps has an excellent cycle retention rate.
A case report of unexplained persistent conjugated hyperbilirubinemia with normal liver transaminases over 23 years: remember Dubin-Johnson syndrome!
Authors: Khan Safeer , Ali Danish , Rehman Sabi Ur 
Published: July 2023

Abstract
Objectives
In clinical practice, clinicians usually ignore the possibility of a rare genetic disease, i.e., Dubin-Johnson Syndrome (DJS), for conjugated hyperbilirubinemia caused by a mutation in the ABCC2 gene or in the MRP2 protein. Therefore, the objective is to alert the readers about our third reported case of DJS in Pakistan. Moreover, we also want to draw the attention of health professionals to potential pharmacotherapeutic management of DJS, and the management of the potential increased susceptibility to drug toxicity.

Case report
We present a case of 23 years old Asian man, with unexplained persistent conjugated hyperbilirubinemia and normal liver transaminases. In 1999, the patient was admitted to a tertiary care hospital for raised conjugated bilirubin (CB), i.e., 67% of total bilirubin (CB; 11 mg/dl, total bilirubin; 16.4 mg/dl). After 19 years, in 2018, during regular checkup by a family physician, the CB was 73% of total bilirubin (CB; 3 mg/dl, total bilirubin; 4.1 mg/dl), while the results of other clinical tests were unremarkable. Soon after 3 years, in 2021, the patient visited a gastroenterologist for jaundiced eyes. Comprehensive clinical tests (CB was 53% of total bilirubin) were accomplished to exclude the other causes of conjugated hyperbilirubinemia, and DJS was diagnosed.

Conclusions
In summary, it is strongly recommended that the cases of unexplained persistent conjugated hyperbilirubinemia should be evaluated for the presence of DJS. Similarly, the drugs that increase the clearance of CB could prove to be a potential management strategy for cases that negatively affect patient’s quality of life.
Fibrin sealant for the prevention of anastomotic leakage after esophagectomy for esophageal or esophagogastric junction cancer: interim report of a prospective, phase III, randomized controlled study
Authors: Zhao Zerui , Li Zhichao , Huang Weizhao , Wang Geng , Mao Teng , Lv Wenqiang , Peng Lin , Chen Jiyang , Yang Hong 
Published: July 2023

Abstract
Purpose
Anastomotic leakage (AL) is one of the most pernicious complications after esophagectomy for patients with esophageal or esophagogastric junction cancer (EC or EJC). The application of fibrin sealant (FS) may be advantageous for reducing the incidence of AL. This study aims to evaluate the safety and effectiveness of FS in preventing AL in patients undergoing McKeown esophagectomy.

Methods
In this multicenter, prospective, randomized controlled trial, we planned to recruit 360 patients aged 18–75 years with resectable EC or EJC and the interim analysis was performed when the number of participants reaches 180. Patients assigned to the FS group received McKeown esophagectomy with 2.5ml FS applied to the cervical anastomosis, while patients in the control group received surgery alone. The primary endpoint was the incidence of cervical AL within the first 3 months postoperatively.

Result
From February 2019 to November 2021, 180 patients were recruited, with 89 in the FS group and 91 in the control group. There was no statistically difference between the incidence of AL between the two groups [6.7% (6/89) in the FS vs. 14.3% (13/91) in the control group, P = 0.16]. Complications was comparable (P = 0.76) between the FS group (42 of 89, 47.2%) and the control group (45 of 91, 49.5%). No adverse events related to FS or deaths occurred postoperatively.

Conclusion
The application of FS intraoperatively is feasible and does not increase the risk of complications, and its effectiveness for the prevention of AL needs to be revalidated after the completion of patient enrollment.

Trial registration
This trial was registered at ClinicalTrials.gov (NCT03847857) on February 19th, 2019.
An Interval-Valued Pythagorean Fuzzy AHP and COPRAS Hybrid Methods for the Supplier Selection Problem
Authors: Erdebilli Babek , Yilmaz İbrahim , Aksoy Tamer , Hacıoglu Umit , Yüksel Serhat , Dinçer Hasan 
Published: July 2023

AbstractCompanies must be able to identify their suppliers appropriately and effectively in order to survive in the competitive market conditions. In order to fulfill and surpass the expectations of the consumers and clients, companies need to interact with the relevant suppliers. It is a tough manner for companies to select the best supplier from a large number of relevant alternatives. The selection process of the appropriate supplier involves multiple interacting and competing factors. Generally, the selection process and its results cause a waste of time and money. For this purpose, MCDM methodologies are utilized to manage this complex process efficiently. MCDMs allows for consistent and accurate decision-making as well as the selection of the most appropriate supplier. MCDM is one the most preferred tool to select the best alternative under the conflicting and competitive criteria when the evaluations are made in crisp numbers. Therefore, MCDM methods are preferred in various applications in academia and real life. However, the evaluations could not be always possible with crisp numbers, especially in vague environments or evaluations needs qualitative data. This study is one of the first to combine the AHP and COPRAS supplier selection methods with interval-valued Pythagorean fuzzy (IPF) logic. The effectiveness of these IPF-AHP and IPF-COPRAS evaluations for the supplier selection problem is compared and examined. The experimental results of case scenarios show that IPF is an effective way to apply in decision-making applications. In addition, sensitivity analysis is conducted to evaluate the proposed methodologies. According to sensitivity analysis, the IPF-AHP and IPF-COPRAS be able to illustrate the effects of small changings in criteria weights. Therefore, companies can use the IPF-AHP and IPF-COPRAS to assist their decision-makers in identifying and selecting the best suppliers.
Building Flood Resilience Among Older Adults Living in Miami-Dade County, Florida
Authors: Bukvic Anamaria , Borate Aishwarya 
Published: July 2023

Abstract

Objective:
This paper explores compounding challenges for older coastal populations due to accelerated sea level rise at the nexus of physical hazard exposure and place-based socioeconomic and health considerations.

Methods:
This study applies geospatial analysis to assess the spatial distribution of older adults (age 65+) and their socioeconomic characteristics in Miami-Dade County in Florida. Next, it uses logistic regression to evaluate the socioeconomic determinants of block groups with 20% or more of residents age 65 and older at 3 feet of sea level rise compared to the other block groups in Miami-Dade.

Results:
The results show that this study area has an older population clustered in flood-prone locations along the shoreline. The block groups with more than 20% of older adults and sea level rise risk have higher homeownership and vacancy rates, a higher percentage of homes constructed before 1980, and more older individuals who live alone.

Conclusion:
This study identifies place-based compounding factors undermining the ability of older residents to adequately cope with accelerated sea level rise flooding in coastal urban locations. Namely, owning an older home in a declining neighborhood and living alone can trap older individuals in place and increase their flood risk.
Convergence and transdisciplinary teaching in quantitative biology
Authors: Mayes Robert , Dauer Joseph , Owens David 
Published: July 2023

Abstract
The United States National Science and Technology Council has made a call for improving STEM (Science, Technology, Engineering, and Mathematics) education at the convergence of science, technology, engineering, and mathematics. The National Science Foundation (NSF) views convergence as the merging of ideas, approaches, and technologies from widely diverse fields of knowledge to stimulate innovation and discovery. Teaching convergency requires moving to the transdisciplinary level of integration where there is deep integration of skills, disciplines, and knowledge to solve a challenging real-world problem. Here we present a summary on convergence and transdisciplinary teaching. We then provide examples of convergence and transdisciplinary teaching in plant biology, and conclude by discussing limitations to contemporary conceptions of convergency and transdisciplinary STEM.
Predicting climate-driven distribution shifts in Hyalomma marginatum (Ixodidae)
Authors: Hekimoglu Olcay , Elverici Can , Kuyucu Arda Cem 
Published: July 2023

AbstractHyalomma marginatum is an important tick species which is the main vector of Crimean–Congo haemorrhagic fever and spotted fever. The species is predominantly distributed in parts of southern Europe, North Africa and West Asia. However, due to ongoing climate change and increasing reports of H. marginatum in central and northern Europe, the expansion of this range poses a potential future risk. In this study, an ecological niche modelling approach to model the current and future climatic suitability of H. marginatum was followed. Using high-resolution climatic variables from the Chelsa dataset and an updated list of locations for H. marginatum, ecological niche models were constructed under current environmental conditions using MaxEnt for both current conditions and future projections under the ssp370 and ssp585 scenarios. Models show that the climatically suitable region for H. marginatum matches the current distributional area in the Mediterranean basin and West Asia. When applied to future projections, the models suggest a considerable expansion of H. marginatum's range in the north in Europe as a result of rising temperatures. However, a decline in central Anatolia is also predicted, potentially due to the exacerbation of drought conditions in that region.