bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personality traits favourable for non-adherence to treatment in patients with chronic myeloid leukaemia: role of type A and D personality
Authors: Rychter Anna , Miniszewska Joanna , Góra-Tybor Joanna 
Published: January 2023

Abstract
Background
The introduction of BCR-ABL tyrosine kinase inhibitors (TKIs) to chronic myeloid leukemia (CML) therapy has revolutionized the treatment of this disease. Although regular TKI intake is a prerequisite for successful therapy, it has been shown that a significant proportion of patients are non-compliant. Recently there is growing evidence that personality traits may influenced the tendency for non-adherence to treatment in patients with chronic diseases. As far as we know, such a relationship in patients with CML has not been examined, yet. The aim of our study was to determine if personality traits favor non-adherence to treatment recommendations. We investigated the relationship between five-factor model personality factors (conscientiousness, neuroticism, agreeableness, extraversion, and openness) and medication non-adherence. We also checked if the patients with type A and type D personality, were at higher risk of poor medication adherence.

Methods
The following tools were used: self-constructed survey, the NEO-Five Factor Inventory, the Framingham Type A Scale, the D-Scale 14. The study included 140 CML patients treated with imatinib, dasatinib, or nilotinib.

Results
39% of patients reported skipping at least one dose of medication in the month prior to follow-up visit. 51% admitted to skipping such doses from the start of their treatment to the time at which our assessment was performed. We did not find any relationship between the mean values of the analyzed factors of the Big Five (neuroticism, extraversion, openness, agreeableness, conscientiousness) and adherence. However, our analysis revealed that CML patients who admitted to missing doses of drugs during the entire course of treatment demonstrated greater intensity of type A personality traits (p = 0.020). Regarding both factors of type D personality, it was revealed that higher level of negative affectivity significantly decreased the adherence (p = 0.020).

Conclusion
The results of our study indicate that screening for type D and A personalities may help to identify patients who are at higher risk of poor medication adherence.
Schimke immunoosseous dysplasia: an ultra-rare disease. a 20-year case series from the tertiary hospital in the Czech Republic
Authors: Zieg Jakub , Bezdíčka Martin , Němčíková Michaela , Balaščáková Miroslava , Suková Martina , Štěrbová Katalin , Vondrák Karel , Dušek Jiří , Křepelová Anna 
Published: January 2023

Abstract
Background
Schimke immunoosseous dysplasia (SIOD) is an ultra-rare inherited disease affecting many organ systems. Spondyloepiphyseal dysplasia, T-cell immunodeficiency and steroid resistant nephrotic syndrome are the main symptoms of this disease.

Case presentation
We aimed to characterize the clinical, pathological and genetic features of SIOD patients received at tertiary Pediatric Nephrology Center, University Hospital Motol, Prague, Czech Republic during the period 2001–2021. The mean age at diagnosis was 21 months (range 18–48 months). All patients presented with growth failure, nephropathy and immunodeficiency. Infections and neurologic complications were present in most of the affected children during the course of the disease.

Conclusions
Although SIOD is a disease characterized by specific features, the individual phenotype may differ. Neurologic signs can severely affect the quality of life; the view on the management of SIOD is not uniform. Currently, new therapeutic methods are required.
Efficacy of self-management program associated with a spa therapy for knee osteoarthritis patients (GETT 2): a research protocol for a randomized trial
Authors: Goldstein A. , Lanhers C. , Gay C. , Dubourg K. , Grange L. , Roques C. F. , Pereira B. , Coudeyre E. 
Published: January 2023

Abstract
Introduction
Osteoarthritis is a chronic pathology that involves multidisciplinary management. Self-management for patients is an essential element, present in all international guidelines. During the time of the spa therapy, the patient is receptive to take the advantage of self-management workshops.
The aim of this study is to assess the effects of 18 days spa therapy associated with a self-management intervention in patients with knee osteoarthritis in comparison with spa therapy alone on a priority objective, personalized and determined with the patient, chosen in the list of 5 objectives determined during the self-management initial assessment.

Methods and analysis
Two hundred fifty participants with knee osteoarthritis will participate to this multicenter, prospective, randomized, controlled study. All patients will benefit 18 days of spa therapy and patients randomized in the intervention group will participate to 6 self-management workshops. Randomization will be centralized. The allocation ratio will be 1:1. Data analysts and assessor will be blinded. The primary outcome is the effectiveness of the educational workshops associated with spa therapy in comparison with spa therapy alone on a priority objective, measured by Goal Attainment Scaling (GAS). The secondary outcomes are disability, health-related quality of life, and pain intensity.

Ethics and dissemination
Ethics were approved by the CPP Sud-Méditerranée II. The results will be disseminated in a peer-reviewed journal and disseminated at PRM, rheumatology, and orthopedics conferences. The results will also be disseminated to patients.

Trial registration
Trial registration number NCT03550547. Registered 8 June 2018.
Date and version identifier of the protocol. Version N°6 of March 12, 2018.
LessStress - how to reduce stress in school: evaluation of a universal stress prevention in schools: study protocol of a cluster-randomised controlled trial
Authors: Scheiner Christin , Daunke Andrea , Seidel Alexandra , Mittermeier Sabrina , Romanos Marcel , Kölch Michael , Buerger Arne 
Published: January 2023

Abstract
Background

Chronic stress is detrimental to health, and children and young people have had to cope with significantly more stress since the start of the COVID-19 pandemic. In particular, stress at school and in relation to learning is a major problem in this age group. Studies in Germany have indicated that the pandemic has led to a reduced quality of life (QoL) and an increased risk for psychiatric disorders in children and adolescents. Schools are an ideal setting for interventions against stress, which is one of the strongest predictors for the development of psychosocial problems. The present study seeks to address stress by means of a short prevention training programme in schools, including emotion regulation, mindfulness, and self-compassion. In addition to information material for self-study, students should have the opportunity to actively deal with the topic of stress and develop coping strategies within a short space of time. In contrast to very long stress reduction programmes that often last several weeks, the programme is delivered in just 90 min.

Methods
The effectiveness of the short and economical prevention programme LessStress will be examined in a cluster-randomised controlled trial (RCT) encompassing 1894 students. At several measurement time points, students from two groups (intervention and control) will be asked about their subjectively perceived stress levels, among other aspects. Due to the clustered nature of the data, mainly multilevel analyses will be performed.

Discussion
In Germany, there are no nationwide universal prevention programmes for students against stress in schools, and this gap has become more evident since the outbreak of the pandemic. Universal stress prevention in schools may be a starting point to promote resilience. By dealing with stress in a healthy way, mental health can be strengthened and maintained. Moreover, to reach at-risk students at an early stage, we advocate for a stronger networking between child psychiatry and schools.

Trial registration
German Clinical Trials Register (DRKS) DRKS00025721. Registered on November 4, 2021
Effects of physical training on functional, clinical, morphological, behavioural and psychosocial outcomes in post-COVID-19 infection: COVID-19 and REhabilitation study (CORE-study)—a study protocol for a randomised controlled clinical trial
Authors: Delevatti Rodrigo Sudatti , Danielevicz Angelica , Sirydakis Maria Eduarda , de Melo Paulo Urubatan Gama , de la Rocha Freitas Cíntia , Rech Cassiano Ricardo , Guglielmo Luiz Guilherme Antonacci , Speretta Guilherme Fleury Fina , Hansen Fernanda , Fonseca Fernanda Rodrigues , Starke Ana Carolina , de Lucas Ricardo Dantas , de Melo Junior José Tavares , Maurici Rosemeri , Gerage Aline Mendes 
Published: January 2023

Abstract
Background
The COVID-19 pandemic remains ongoing, with a significant number of survivors who have experienced moderate to severe clinical conditions and who have suffered losses of great magnitude, especially in functional capacity, triggering limitations to daily autonomy and quality of life. Among the possibilities of intervention for disease rehabilitation, physical exercise training stands out, which can benefit several health outcomes and favours the adoption of healthier behaviours. Therefore, the aim of the study will be to analyse the effects of physical training on the functional, clinical, morphological, behavioural and psychosocial status in adults and the elderly following COVID-19 infection.

Methods
A randomised controlled clinical trial is to be conducted in parallel, with the experimental group undergoing an intervention involving a multicomponent physical rehabilitation programme, carried out at the Sports Center in partnership with the Academic Hospital of the Federal University of Santa Catarina, in Florianópolis, Brazil. Participants will be adults and the elderly, of both sexes, in a post-COVID-19-infection state, who were hospitalised during the infection. The intervention will have a total duration of 24 weeks and will include a multicomponent physical training programme, which will have gradual progression in frequency, duration and intensity over time. Regarding the outcomes, before, at the 12th and after 24 weeks of intervention, functional (primary outcome = functional index of aerobic capacity), clinical, morphological, behavioural and psychosocial outcomes will be assessed.

Discussion
This study will contribute to a greater understanding of the safety, adherence and benefits of physical training in the rehabilitation of post-COVID-19 patients. The results of this study will be disseminated through presentations at congresses, workshops, peer-reviewed publications and local and international conferences, especially with a view to proposing a post-COVID-19 rehabilitation care protocol.

Trial registration
ReBEC, RBR-10y6jhrs. Registered on 22 February 2022. 2015.
Dermatofibrosarcoma protuberans challenges: a case series and review of the literature
Authors: Sheidaei Somayeh , Salehi Mahsa , Abedian kenari Fatemeh , Jafari Hamid Reza 
Published: January 2023

Abstract
Background
Dermatofibrosarcoma protuberans (DFSP) is a rare variant of skin sarcoma which is characterized by proliferation of spindle cells in a storiform pattern. Although it is mostly benign in its primary stages, it can cause a high burden of morbidity unless it is thoroughly excised.

Case presentation
Here, we review six cases of DFSP which were characterized by skin lesions in various parts of the body. Patients were from 26 to 51 years old; four were Asian men and two were Asian women. Wide surgical excision was performed for all these patients and no extra treatment was considered. Samples were studied by hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) tests. Only one of our patients experienced recurrence after the initial surgery.

Conclusion
Determining the best surgical method is still a dilemma in the treatment of DFSP lesions. There are numerous studies to prove the efficacy of various surgical interventions. Although DFSP is not commonly known as a malignant skin lesion, delay in treatment will have a catastrophic impact on patients’ lives. Thus, applying an in-time surgical method (wide local excision in our cases) in treating DFSP is crucial in preventing recurrence as well as decreasing the morbidity burden of DFSP.
Loss of TET2 impairs endothelial angiogenesis via downregulating STAT3 target genes
Authors: Shi Yefei , Li Bo , Huang Xinru , Kou Wenxin , Zhai Ming , Zeng Yanxi , You Shuangjie , Yu Qing , Zhao Yifan , Zhuang Jianhui , Peng Wenhui , Jian Weixia 
Published: January 2023

Abstract
Background
Ischemic diseases represent a major global health care burden. Angiogenesis is critical in recovery of blood flow and repair of injured tissue in ischemic diseases. Ten–eleven translocation protein 2 (TET2), a member of DNA demethylases, is involved in many pathological processes. However, the role of TET2 in angiogenesis is still unrevealed.

Methods
TET2 was screened out from three DNA demethylases involved in 5-hydroxylmethylcytosine (5-hmC) regulation, including TET1, TET2 and TET3. Knockdown by small interfering RNAs and overexpression by adenovirus were used to evaluate the role of TET2 on the function of endothelial cells. The blood flow recovery and density of capillary were analyzed in the endothelial cells-specific TET2-deficient mice. RNA sequencing was used to identify the TET2-mediated mechanisms under hypoxia. Co-immunoprecipitation (Co-IP), chromatin immunoprecipitation-qPCR (ChIP-qPCR) and glucosylated hydroxymethyl-sensitive-qPCR (GluMS-qPCR) were further performed to reveal the interaction of TET2 and STAT3.

Results
TET2 was significantly downregulated in endothelial cells under hypoxia and led to a global decrease of 5-hmC level. TET2 knockdown aggravated the hypoxia‐induced dysfunction of endothelial cells, while TET2 overexpression alleviated the hypoxia‐induced dysfunction. Meanwhile, the deficiency of TET2 in endothelial cells impaired blood flow recovery and the density of capillary in the mouse model of hindlimb ischemia. Mechanistically, RNA sequencing indicated that the STAT3 signaling pathway was significantly inhibited by TET2 knockdown. Additionally, Co-IP, ChIP-qPCR and GluMS-qPCR further illustrated that STAT3 recruited and physically interacted with TET2 to activate STAT3 target genes. As expected, the effects of TET2 overexpression were completely suppressed by STAT3 silencing in vitro.

Conclusions
Our study suggests that the deficiency of TET2 in endothelial cells impairs angiogenesis via suppression of the STAT3 signaling pathway. These findings give solid evidence for TET2 to be a therapeutic alternative for ischemic diseases.

Graphical Abstract
Beyond the Big Five personality traits for music recommendation systems
Authors: Kleć Mariusz , Wieczorkowska Alicja , Szklanny Krzysztof , Strus Włodzimierz 
Published: January 2023

AbstractThe aim of this paper is to investigate the influence of personality traits, characterized by the BFI (Big Five Inventory) and its significant revision called BFI-2, on music recommendation error. The BFI-2 describes the lower-order facets of the Big Five personality traits. We performed experiments with 279 participants, using an application (called Music Master) we developed for music listening and ranking, and for collecting personality profiles of the users. Additionally, 29-dimensional vectors of audio features were extracted to describe the music files. The data obtained from our experiments were used to test several hypotheses about the influence of personality traits and the audio features on music recommendation error. The performed analyses take into account three types of ratings that refer to the cognitive-emotional, motivational, and social components of the attitude towards the song. The experiments showed that every combination of Big Five personality traits produces worse results than using lower-order personality facets. Additionally, we found a small subset of personality facets that yielded the lowest recommendation error. This finding can condense the personality questionnaire to only the most essential questions. The collected data set is publicly available and ready to be used by other researchers.
Unravelling mechanisms underlying the action principles of a community-based health promotion programme: a realist evaluation
Authors: de Jong Marja A. J. G. , Wink Gerda , Koelen Maria A. , Wagemakers Annemarie 
Published: January 2023

Abstract
Background
Since 1986, WHO has advised that applying action principles such as citizen participation and intersectoral collaboration leads to better health. However, less is known about the workability of these principles and how they trigger specific outcomes in interaction with the context. A critical realist perspective was applied to get a better understanding of what worked, and why it worked, in the context of a Dutch community-based health promotion programme (CBHPP). The aim of the study was to unravel the mechanisms underlying the action principles and find combinations of contextual factors and mechanisms that trigger outcomes in a CBHPP.

Methods
In this single case study, a critical realist methodology was followed. Qualitative data used in this study originated from multiple sources and methods to ensure validity. They include evaluation sessions with coalition members (n = 6) and individual interviews (n = 6); group sessions with community workers (n = 1), a health broker (n = 1), and citizens (n = 12); and seven semi-annual progress reports and minutes of the coalition meetings. The collected data were then compared with the programme theory through a heuristic process of constructing, exploring, and refining context-mechanism-outcome configurations.

Results
The programme initiated a variety of new activities that differed in content, intensity, duration, and number of participants, organised and implemented together with citizens. The most prominent mechanism underlying both action principles were programme-related, namely, patience, personal contact, contribution of budget, and the programme coordinator’s leadership. Another important mechanism was creating visibility, which resulted in the involvement of the municipality and a budget to sustain the programme.

Conclusion
In this case study, personal contact, patience, perseverance, participatory action research activities, and visibility were found to be the most notable mechanisms underlying the citizen participation and intersectoral collaboration action principles. As the principle-based approach added value to the existing context and introduced most of the mechanisms that triggered the outcomes, it is recommended to include citizen participation and intersectoral collaboration not only as action principles but explicitly as targets in a CBHPP.
The relation between wheat, soybean, and hemp acreage: a Bayesian time series analysis
Authors: Han Joohun , Ng’ombe John N. 
Published: January 2023

AbstractThe 2018 United States Farm Bill has opened the possibility for farmers to increase their profits through hemp cultivation. The literature suggests hemp has the potential to replace soybeans in soybean–wheat double-cropping because hemp shares key attributes of soybeans as a rotation crop (profitability, potential as an energy crop, and maintenance of soil fertility). Nonetheless, due to a short history of hemp cultivation in the USA, it is difficult to predict a time series relationship between hemp, soybean, and wheat through conventional approaches. In this article, we use Bayesian time series models and data from Statistics Canada and the Alberta Agricultural and Rural Development Department to examine a time series relationship between hemp, wheat, and soybean acreage and therefore predict farmers’ decision when hemp is a legal alternative agricultural commodity. Our results show evidence of complementary and substitution relationships for hemp–wheat and hemp–soybean, respectively. In addition, the results indicate a potential of hemp monoculture as a positive response to self-positive shock on hemp acreage that lasts for years.
Intraoperative video recording in otolaryngology for surgical education: Evolution and considerations
Authors: Brennan Hannah L. , Kirby Simon D. 
Published: January 2023

Background Otolaryngology is a surgical speciality well suited for the application of intraoperative video recording as an educational tool considering the number procedures within the speciality that utilize digital technology. Intraoperative recording has been utilized in endoscopic surgeries and in evaluating technique in mastoidectomy, myringotomy and grommet insertion. The impact of intra-operative video recording in otolaryngology education is vast in creating access to surgical videos for preparation outside the operating room to individualized coaching and assessment. The purpose of this project is to highlight the role of intraoperative video recording in otolaryngology training and elucidate the challenges and considerations associated with implementation. Methods Related publications between 1999 to 2022 were reviewed from PubMed and Embase databases utilizing search terms “intraoperative videography,” “video recording surgery,” “otolaryngology,” and “surgical education.” 109 articles were screened independently by HB and SK, by title and abstract then full text review. 28 articles from the original search and 6 from the secondary reference review were included. Results The application of intraoperative video recording is evident in otolaryngology surgeries including endoscopic sinus surgery, laryngeal surgery, and other endoscopic procedures. There have been significant advancements in recording tools, including devices that can capture the surgeon's perspective. The considerations and challenges identified with utilizing this educational tool were categorized into different themes including ethics/consent, regulation, liability, data, technology, and human resources. Conclusion Intra-operative video recording has been demonstrated to have significant impact within otolaryngology education. It is critical to elucidate the challenges and considerations involved to utilize this educational tool effectively. Future directives will see video-based performance analytics providing comparative metrics to encourage precise coaching of surgical residents.
Coral distribution and diversity in Sakiyamawan–Amitoriwan nature conservation area of Iriomote Island in Japan
Authors: Shimokawa Shinya , Murakami Tomokazu , Kohno Hiroyoshi 
Published: January 2023

AbstractSakiyama and Amitori bays of Iriomote Island in Japan are adjacent, but their coral distributions differ significantly. This study investigates the differences in the coral distribution and diversity between both bays from the diversity index and intermediate disturbance hypothesis (IDH) perspective. In Amitori Bay, tabular and branching corals dominate the mouth and inner part of the bay, respectively. Coral diversity is maximum in the intermediate part of the bay, realizing the IDH. In Sakiyama Bay, branching and massive corals dominate the reef edge and coast sides of the bay’s intermediate part, respectively. Coral diversity is maximum in the reef edge part of the bay, and IDH is not realized. The difference in the soil inflow and geographical characteristics between both bays significantly affects their coral distribution and diversity.