bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexually dimorphic differences in angiogenesis markers predict brain aging trajectories
Authors: Torres-Espin A , Rabadaugh Hannah , Fitzsimons S , Harvey D , Chou A , Lindberg C , Casaletto KB , Goldberger L , Staffaroni AM , Maillard P , Miller BL , DeCarli C , Hinman JD , Ferguson AR , Kramer JH , Elahi FM 
Published: July 2023

ABSTRACTAberrant angiogenesis could contribute to cognitive impairment, representing a therapeutic target for preventing dementia. However, most angiogenesis studies focus on model organisms. To test the relevance of angiogenesis to human cognitive aging, we evaluated associations of circulating blood markers of angiogenesis with brain aging trajectories in two deeply phenotyped human cohorts (n=435, age 74+9) with longitudinal cognitive assessments, biospecimens, structural brain imaging, and clinical data. Machine learning and traditional statistics revealed sex dimorphic associations of plasma angiogenic growth factors with brain aging outcomes. Specifically, angiogenesis is associated with higher executive function and less brain atrophy in younger women (not men), a directionality of association that reverses around age 75. Higher levels of basic fibroblast growth factor, known for pleiotropic effects on multiple cell types, predicted favorable cognitive trajectories. This work demonstrates the relevance of angiogenesis to brain aging with important therapeutic implications for vascular cognitive impairment and dementia.
How does femvertising work in a patriarchal context? An unwavering consumer perspective
Authors: Amir Aleena , Roca David , Sadaf Lubaba , Obaid Asfia 
Published: July 2023

PurposeGiven the extensive evidence of femvertising's positive effects in Western cultures, this paper aims to investigate how femvertising may influence customers' perceptions and brand-related outcomes in a patriarchal context such as Pakistan.Design/methodology/approachQualitative methodology was employed in this study, which was based on in-depth interviews involving 17 consumers (including both male and females). Thematic analysis was used to analyse the data.FindingsResults indicated that male and female consumers revealed varied and sometimes contradictory perspectives on the perception, understanding and behaviour towards femvertised adverts, which are governed by patriarchal gendered norms.Originality/valueThis study contributes to the body of knowledge by exploring the consumer perception towards femvertising in a patriarchal context, where gender disparity is evident. It also draws attention to the underlying cultural elements contributing towards the formation of those perceptions.
Evaluation of the impact of a self-stigma reduction programme on psychosocial outcomes among people with schizophrenia spectrum disorder
Authors: Hasan Abd , Alsharawneh Anas , Alasamee Nofaa 
Published: July 2023

Purpose
The purpose of this study is to evaluate the effectiveness of a self-stigma reduction programme on self-stigma.

Design/methodology/approach
A randomized controlled trial was conducted from November 2017 to December 2018 with 278 people diagnosed with schizophrenia (PDwS). Participants were randomly assigned to receive a self-stigma reduction programme (psychoeducation, cognitive behavioural therapy and social skills training) or treatment as usual.

Findings
PDwS in the intervention group experienced a greater reduction in the level of self-stigma (20.19 vs −0.62; p < 0.001) at post-intervention and (37.35 vs −0.66; p < 0.001) at six-month follow-up.

Originality/value
The first RCT examines the problem and implements intervention in middle east country. Also, the authors have conducted high-quality RCT.
Influence of single‐room accommodation on nursing care: A realistic evaluation
Authors: Søndergaard Susanne Friis , Andersen Anne Bendix , Kolbæk Raymond , Beedholm Kirsten , Frederiksen Kirsten 
Published: July 2023

AbstractNowadays, it is common that newly built hospitals are designed with single‐room accommodation, unlike in the past, where shared accommodation was the favoured standard. Despite this change in hospital design, very little is known about how single‐room accommodation affects nurses' work environment and nursing care. This study evaluates how the single‐room design affects nurses and nursing care in the single‐room hospital design. Nurses working in the single‐room design predominantly work alone with little opportunity for peer training, interaction and reflection. In addition, the single‐room design affects the nurses' work environment due to changes in sensory stimulation and increased walking distances. Furthermore, a change in the discourse, namely, regarding the single room as the patient's home, makes the nurses react to queries, demands and tasks in a new way. Overall, the new hospital design forces the nurses into a more reactive role and affect their way of providing nursing care. Despite this, the nurses find single‐room accommodation beneficial for the patients and their nursing care.
Dynamics of a Parallel-Kinematics Machine With Six Pairs of Offset Joints
Authors: Han Hasiaoqier , Angeles Jorge 
Published: July 2023

Abstract
The authors propose a systematic formulation of the dynamics of the 6-P-RR-R-RR parallel-kinematics machine (PKM) with offset RR -joints. The kinematics of the same system is reported in an accompanying paper. Based on the kinematics model developed in the former, the dynamics model of the limb-chain is derived here using the Newton–Euler equations. Then, the constraint wrenches in the governing equations of the limb-chain are eliminated with the aid of the natural orthogonal complement. This is the twist-shaping matrix, which maps the joint-rate array of the limb-chain into the twist array of the PKM. Furthermore, the dynamics model of the whole PKM with offset joints is formulated. Moreover, the actuator forces are obtained. Finally, upon validation via simulation, the dynamics model is proven to be both precise and effective.
Configuration Synthesis Method of Multi-Mode Parallel Mechanism Based on Variable Mobility Branch
Authors: Gao Xueyuan , Li Fujuan , Han Xueyan , Liu Xinwang , Li Shihua 
Published: July 2023

Abstract
In order to obtain more configurations of multi-mode parallel mechanism with the expected motion modes, a new configuration synthesis method of multi-mode parallel mechanism is proposed in this paper. The generation principle of parallel mechanism with multiple motion modes is analyzed. The relation between the motion of moving platform and the motion of branch is obtained. The finite motion and instantaneous motion of existing variable mobility branches are analyzed, and variable mobility branches are decomposed into variable mobility generators. By using variable mobility generators to construct variable mobility branches, a configuration synthesis method of multi-mode parallel mechanism based on variable mobility branch is proposed. Taking the multi-mode parallel mechanism with 2T1R and 2R1T motion modes as an example, a new class of multi-mode parallel mechanisms is obtained. The proposed method enriches the configuration synthesis theory of multi-mode parallel mechanism and the synthesis results enrich the configurations of multi-mode parallel mechanism.
The Unprecedented Current Increase in the Amount of Charcoal Particles in Sediments of Lakes of the North Minusinsk Basin (Southern Siberia): Possible Evidence of Anthropogenic Influence
Authors: Rogozin D. Yu. , Burdin L. A. , Bolobanshchikova G. N. , Degermendzhy A. G. 
Published: July 2023

Abstract
The distribution of charcoal particles >100 µm in size, which are indicators of plant combustion in ambient territories, are analyzed in sediments of Shira and Uchum lakes located in southern Siberia in the steppe zone of the North Minusinsk Basin (Republic of Khakasiya and Krasnoyarsk krai). The age of the lakes is to 1400 and 500 years, respectively. The lacustrine sediments contain charcoal particles of three types. Particles of group 1 have elongated morphology and are interpreted as remnants of grassy plants and/or conifers. Particles of group 2 look like thin plates similar to relics of leaves and bark of trees. Group 3 is composed of various irregular volumetric particles, which are probably relics from wood and coal combustion. The particles of group 1 are mostly indicators of natural fires, and their amount is almost constant in the current period. The amount of charcoal particles of groups 2 and, mostly, 3 has strongly increased in past 100 years, which reflects an increase in the amount of artificially combusted wood and coal in the vicinities of the lakes in the present-day industrial period. An increase in the contribution of the charcoal particles to lacustrine sediments over the past 100 years has been detected for the first time for this region, which is unprecedented for the period of study. This is evidence of the anthropogenic impact on the dynamics of charcoal particles in lacustrine sediments. Our data can be useful for reconstruction of the dynamics of natural fires and the paleoclimate in southern Siberia in the Late Holocene.
Some Features of the Process of Interaction of Iron with Methane at a Temperature of 900°C and a Pressure of 100 MPa
Authors: Aranovich L. Ya. , Persikov E. S. , Bukhtiyarov P. G. , Shaposhnikova O. Y. , Nekrasov A. N. 
Published: July 2023

Abstract
Using the original high-gas pressure unit (IHPV), experiments were conducted for the first time on the interaction of iron with methane at a temperature of 900°C and a pressure of 100 MPa. Complex methods (microprobe, Raman spectroscopy, chromatography, mass balance calculations) are used for a thorough analysis of fluid compositions and metallic phases formed in experiments. For the first time, experimental and theoretical quantitative data on the composition of the fluid and the composition of the fluid components dissolved in the metal were obtained. Unlike the previously studied Fe3C–H2 system, in experiments, when Fe reacts with methane, there is an active interaction of carbon formed due to the pyrolysis of methane with iron up to the synthesis of Fe3C carbide. The experiments have shown that increasing pressure inhibits significantly hydrogen yield during methane conversion on metallic iron. Carbon saturation of iron with the formation of Fe3C is not complete within the entire volume of the metal during 24 h runs at 900°С. Employing molybdenum containers facilitates CH4 decomposition.
Use of a Rapid Rhino in haemorrhage control for penetrating neck injury presenting in traumatic cardiac arrest
Authors: Davies F , O’Meara M , Hudson C 
Published: July 2023

Background Penetrating neck injuries present as serious, life-threatening events which require advanced expeditious management if the patient is to survive without significant morbidity and mortality. In-hospital paradigms for high-volume centres include the use of Foley catheter balloon tamponade to temporarily or definitively control haemorrhage from carotid sheath structures, although these techniques are less commonly deployed in the field. Case report We highlight the case of a 25-year-old male who presented to the ambulance service with three self-inflicted neck wounds – one to each of the zones of the neck. The zone 2 wound had transected the internal jugular vein and also the ipsilateral vertebral artery, causing severe haemorrhage leading to hypovolaemic cardiac arrest in a remote farmhouse location. He was treated with a modified tamponade technique, employing the use of a Rapid Rhino 900™ epistaxis catheter, secured with sutures into the zone 2 wound prior to inflation. This resulted in complete haemostasis, which allowed the patient to be volume resuscitated, anaesthetised and flown by air ambulance to the regional trauma centre. His injuries were treated and his recovery was interrupted only by a transient Horner's syndrome. Discussion This report showcases the first time this modification of a well-known in-hospital technique was deployed, which proved life-saving in this case and could be of use to others. We discuss the importance of catheter tamponade techniques as opposed to direct packing, in particular for those who need to be transported either within, between or to the hospital. This is in contradistinction to other authors advocating direct packing as the mainstay of treatment.
Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia
Authors: Baird Lydia , Cannon Ping , Kandel Manju , Nguyen Tuong-Vi , Nguyen Anna , Wong Georgia , Murphy Cíara , Brownfoot Fiona C. , Kadife Elif , Hannan Natalie J. , Tong Stephen , Bartho Lucy A. , Kaitu’u-Lino Tu’uhevaha J. 
Published: July 2023

Abstract
Background
Preeclampsia is a severe complication of pregnancy which is attributed to placental dysfunction. The retrotransposon, Paternal Expressed Gene 10 (PEG10) harbours critical placental functions pertaining to placental trophoblast cells. Limited evidence exists on whether PEG10 is involved in preeclampsia pathogenesis. This study characterised the expression and regulation of PEG10 in placentas from patients with early-onset preeclampsia compared to gestation-matched controls.

Methods
PEG10 expression was measured in plasma and placentas collected from patients with early-onset preeclampsia (< 34 weeks’) and gestation-matched controls using ELISA (protein) and RT-qPCR (mRNA). First-trimester human trophoblast stem cells (hTSCs) were used for in vitro studies. PEG10 expression was measured during hTSC differentiation and hTSC exposure to hypoxia (1% O2) and inflammatory cytokines (IL-6 and TNFα) using RT-qPCR. Functional studies used PEG10 siRNA to measure the effect of reduced PEG10 on canonical TGF-$$\beta$$
β
signalling and proliferation using luciferase and xCELLigence assays, respectively.

Results
PEG10 mRNA expression was significantly reduced in placentas from patients with early-onset preeclampsia (< 34 weeks’ gestation) relative to controls (p = 0.04, n = 78 vs n = 18 controls). PEG10 protein expression was also reduced in preeclamptic placentas (p = 0.03, n = 5 vs n = 5 controls, blinded assessment of immunohistochemical staining), but neither PEG10 mRNA nor protein could be detected in maternal circulation. PEG10 was most highly expressed in hTSCs, and its expression was reduced as hTSCs differentiated into syncytiotrophoblasts (p < 0.0001) and extravillous trophoblasts (p < 0.001). Trophoblast differentiation was not altered when hTSCs were treated with PEG10 siRNA (n = 5 vs n = 5 controls).
PEG10 was significantly reduced in hTSCs exposed to hypoxia (p < 0.01). PEG10 was also reduced in hTSCs treated with the inflammatory cytokine TNF $$\alpha$$
α
(p < 0.01), but not IL-6. PEG10 knocked down (siRNA) in hTSCs showed reduced activation of the canonical TGF-β signalling effector, the SMAD binding element (p < 0.05) relative to controls. PEG10 knockdown in hTSCs however was not associated with any significant alterations in proliferation.

Conclusions
Placental PEG10 is reduced in patients with early-onset preeclampsia. In vitro studies suggest that hypoxia and inflammation may contribute to PEG10 downregulation. Reduced PEG10 alters canonical TGF-$$\beta$$
β
signalling, and thus may be involved in trophoblast dysfunction associated with this pathway.
Endoplasmic reticulum stress: a novel targeted approach to repair bone defects by regulating osteogenesis and angiogenesis
Authors: Wu Tingyu , Jiang Yaping , Shi Weipeng , Wang Yingzhen , Li Tao 
Published: July 2023

AbstractBone regeneration therapy is clinically important, and targeted regulation of endoplasmic reticulum (ER) stress is important in regenerative medicine. The processing of proteins in the ER controls cell fate. The accumulation of misfolded and unfolded proteins occurs in pathological states, triggering ER stress. ER stress restores homeostasis through three main mechanisms, including protein kinase-R-like ER kinase (PERK), inositol-requiring enzyme 1ɑ (IRE1ɑ) and activating transcription factor 6 (ATF6), collectively known as the unfolded protein response (UPR). However, the UPR has both adaptive and apoptotic effects. Modulation of ER stress has therapeutic potential for numerous diseases. Repair of bone defects involves both angiogenesis and bone regeneration. Here, we review the effects of ER stress on osteogenesis and angiogenesis, with emphasis on ER stress under high glucose (HG) and inflammatory conditions, and the use of ER stress inducers or inhibitors to regulate osteogenesis and angiogenesis. In addition, we highlight the ability for exosomes to regulate ER stress. Recent advances in the regulation of ER stress mediated osteogenesis and angiogenesis suggest novel therapeutic options for bone defects.
Benzodiazepine use, quality of life and psychiatric symptom burden in oral and injectable opioid agonist treatment: a cross-sectional study
Authors: Meyer Maximilian , Gygli Ferdinand , Westenberg Jean N. , Schmid Otto , Strasser Johannes , Lang Undine E. , Dürsteler Kenneth M. , Vogel Marc 
Published: July 2023

Abstract
Background
Use of benzodiazepines (BZD) in patients receiving opioid agonist treatment (OAT) is common and associated with a variety of negative health and social outcomes. This cross-sectional study investigates the impact of BZD use in OAT patients on their quality of life (QoL).

Methods
A convenience sample of patients receiving oral OAT or heroin-assisted treatment in two outpatient centres in Basel, Switzerland was investigated. Participants (n = 141) completed self-report questionnaires on psychiatric symptoms and psychological distress (The Symptom Checklist 27, SCL-27), depressive state (German version of the Center for Epidemiological Studies Depression Scale), quality of life (Lancashire Quality of Life Profile, LQOLP) and use of BZD and other drugs (self-report questionnaire). Substance use was assessed by urine toxicology testing.

Results
In bivariate analysis, total QoL scores were significantly lower for lifetime, current, and prolonged BZD users compared to participants without the respective use patterns. There was no significant relationship between BZD dose and QoL. In multivariable linear regression models controlling for psychiatric symptom load and depressive state, only lifetime use predicted lower QoL, whereas other BZD use patterns were not significantly associated.

Conclusions
The association of lower QoL and BZD use in OAT patients is strongly confounded by co-occurring depressive state and psychiatric symptoms. Careful diagnosis and treatment of co-occurring mental disorders in OAT is paramount to improve QoL in this patient population and may also help reduce BZD use.
Integration of photogrammetry and laser scanning for enhancing scan-to-HBIM modeling of Al Ula heritage site
Authors: Alshawabkeh Yahya , Baik Ahmad 
Published: July 2023

Abstract
The study highlights the significance of combining imaging and laser scanning techniques to enrich point clouds used for reliable documentation and Heritage Building Information Modeling (HBIM). The fusion-based approach was used to document Al Ula Heritage site in Saudi Arabia, a UNESCO World Heritage Site with well-preserved tombs from the first century BC. The HBIM parametric modeling process requires a detailed survey to collect all geometric data. Although terrestrial laser scanners (TLS) are an efficient tool for 3D recording of heritage scenes in a short period of time, the data resolution is insufficient for identifying and evaluating the spatial distribution of surface weathering forms. Furthermore, combining scans collected at different times may pose difficulties in recording the texture. These issues have an impact on the subsequent 3D modeling phase as well as the efficiency of interpreting and tracing surface features in the Scan-to-BIM process. The proposed workflow using imagery data to enhance both the geometry and coloring of laser point clouds. In addition to texture mapping, the high-resolution imagery is used to densify the laser data using dense image matching, allowing for a clear reading of the surface features, and serving as a useful tool to identify the type, extent, and severity of façade damage. TLS and imagery data were collected separately, with images taken at the best time and location for realistically recording of surface details. Finally, the captured images are orthorectified by TLS geometric information and used for HBIM texturing to provide realistic decay mapping. The results showed that the combination of TLS and photogrammetry allowed for the efficient collection of 3D data, which improved tracing and digitizing HBIM with complete mapping information. The research findings will be greatly useful in the management and planning of historic building conservation and restoration projects.
Fibromyalgia with psoriatic and rheumatoid arthritis: relationship with disease activity and serum vitamin D level
Authors: Abozaid Hanan S. , Khalaf Alshimaa Hamdy , Elgendy Dalia S. , Ahmed Rabab Hussein Ali 
Published: July 2023

Abstract
Background
The study of the relationship between the presence of fibromyalgia (FM) with rheumatoid (RA) and psoriatic arthritis (PsA) patients can affect the main disease outcome and the treatment decision. The research aims to assess the associated fibromyalgia and vitamin D level in rheumatoid and psoriatic arthritis patients.

Results
A cross-sectional study included 60 RA, 30 PsA, and 40 healthy controls, all of them were evaluated for the diagnosis of FM and serum vitamin D level, disease activity score 28 (DAS28), and health quality of life. The mean age of RA was 47.75 ± 11.11 SD, for PsA 44.17 ± 10.8 SD, and for the controls 44.35 ± 13.64 with no significant differences. FM was diagnosed in 21.7% of RA, 13.3% of PsA, and 2.5% of healthy controls with a significant difference among the three groups (P value = 0.025). RA and PsA patients with concomitant FM showed statistically significant higher disease activity scores, significantly worse quality of life than those without FM, and significantly lower serum vitamin D than those without FM.

Conclusion
Vitamin D deficiency and the presence of FM can be related to higher disease activity and less response to treatment, early recognition and treatment of FM and vitamin D deficiency in RA and PsA patients could be important to obtain a good response to therapy and achieve remission.