bluuebunny/crossref_metadata_2025_split huggingface dataset:
Edukasi dan upaya pencegahan kekerasan seksual pada remaja
Authors: Sari Desita , Rahmaniah Syarifah Ema , Yuliono Agus , Alamri Annisa Risqa , Utami Sonia , Andraeni Vindy , Wati Riska 
Published: August 2023

Desa Gunungrejo yang terletak di Kecamatan Singasari Kabupaten Berdasarkan data Komisi Perlindungan Anak Indonesia (KPAI) Kabupaten Mempawah, kasus kekerasan seksual terjadi peningkatan. Kekerasan seksual ini kerap kali menimbulkan korban yang dianggap sebagai oknum-oknum yang lemah seperti perempuan dan anak–anak yang masih di bawah umur. Hadirnya kekerasan seksual ini tentunya menjadi sebuah permasalahan yang cukup besar yang mana hal ini akan menimbulkan dampak yang negatif kepada korban. Tujuan kegiatan ini yaitu untuk meningkatkan kesadaran dan penguatan upaya pencegahan serta penanganan kekerasan seksual di lingkungan remaja dan sekolah. Metode kegiatan dilaksanakan dengan pendekatan Participatory Action Research (PAR). Aksi dilaksanakan dengan model ceramah, diskusi dan disertai game di SMPN 2 Segedong, Kabupaten Mempawah, Kalimantan Barat. Adapun materi yang disampaikan oleh kami berisikan tentang materi pengertian kekerasan seksual, pentingnya edukasi seksual, bentuk-bentuk dari kekerasan seksual, macam-macam kekerasan seksual, dampak dari kekerasan seksual dan hukum yang mengatur & melindungi korban tindak pidana dalam kekerasan seksual. Kasus kekerasan seksual terjadi peningkatan dari tahun ke tahun dan remaja menjadi kelompok rentan yang menjadi korban. kasus pelecehan seksual ini bisa terjadi karena adanya pemain kekuasaan (Quid Pro Quo). Penting untuk pihak sekolah membuat kebijakan untuk mencegah dan menangani kekerasan seksual. Para remaja juga mesti tahu apa yang dilakukan ketika mendapat kekerasan seksual. Selain itu perlu membuat gerakan upaya apa saja yang bisa mereka lakukan untuk melawan kasus kekerasan di lingkungan sekolah. Hasil kegiatan ini memperlihatkan adanya peningkatan pengetahuan, afektif dan psikomotor terkait pencegahan dan penanganan kekerasan seksual.
ANALISIS PENGARUH VARIABEL PENGAUDITAN DAN VARIABEL KEUANGAN TERHADAP OPINI AUDIT GOING CONCERN
Authors: Lim Alex Christian , Stephanus Daniel Sugama 
Published: August 2023

ABSTRAK
Penelitian ini bertujuan untuk membuktikan pengaruh variabel-variabel terhadap opini audit going concern. variabel-variabel tersebut terdiri atas dua faktor, yaitu faktor pengauditan dan faktor keuangan. Faktor pengauditan yang digunakan dalam penelitian ini terdiri atas kualitas audit, reputasi auditor, audit tenure, audit lag, dan opinion shopping. Kemudian, faktor keuangan yang digunakan dalam penelitian ini terdiri atas profitabilitas, likuiditas, solvabilitas, dan leverage. Sampel yang digunakan dalam penelitian ini adalah perusahaan manufaktur sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia. Pemilihan sampel dilakukan dengan menggunakan teknik purposive sampling. Berdasarkan proses seleksi sampel, diperoleh sejumlah 33 sampel perusahaan dan periode pengamatan penelitian dilakukan selama 5 periode tahun, sehingga jumlahnya yaitu 165 data, dari 33 perusahaan manufaktur sektor industri barang konsumsi selama 5 tahun. Jenis data yang digunakan adalah data sekunder yang dipublikasikan oleh Bursa Efek Indonesia, berupa data laporan keuangan auditan beserta laporan auditor independen perusahaan manufaktur sektor industri barang konsumsi. Teknik pengumpulan data dilakukan dengan teknik dokumentasi dengan cara mencari dan mengumpulkan data objek penelitian. Analisis dalam penelitian ini menggunakan regresi logistik. Hasil penelitian ini menunjukkan bahwa, seluruh variabel independen yang digunakan dalam penelitian ini, tidak berpengaruh signifikan terhadap opini audit going concern. Hal ini disebabkan karena dalam penelitian ini menggunakan sampel pada perusahaan yang tidak mengalami laba negatif (kerugian). Sehingga diperoleh hasil bahwa seluruh variabel independen yang digunakan dalam penelitian ini, tidak berpengaruh signifikan terhadap pemberian opini audit going concern pada perusahaan yang mengalami laba bersih positif (keuntungan).
Kata-kata Kunci: Opini Audit Going Concern, Kualitas Audit, Reputasi Auditor, Audit Tenure, Audit Lag, Opinion Shopping, Profitabilitas, Likuiditas, Solvabilitas, Leverage.
PERAN PERUSAHAAN KELUARGA, DIVERSIFIKASI PERUSAHAAN DAN LEVERAGE DALAM MANAJEMEN LABA
Authors: Damara Devina , Lembut Putu Indrajaya , Oktariani Fitri 
Published: August 2023

Penelitian ini bertujuan untuk membuktikan keterkaitan antara perusahaan keluarga, diversifikasi perusahaan dan leverage terhadap manajemen laba dengan good corporate governance sebagai variabel moderasi. Manajemen laba diproksi dengan menggunakan discretionary accrual. Variabel utama dependen dalam penelitian ini yaitu perusahaan keluaraga, diversifikasi perusahaan dan leverage. Peneliti juga melakukan uji beda pada variabel leverage sebelum dan selama Covid19. Sampel dalam penelitian ini adalah perusahaan keluarga di bidang manufaktur yang terdaftar di BEI pada periode 2017-2021. Sampel uji beda pada penelitian ini menggunakan tahun 2018-2019 sebelum Covid19 dan 2020-2021 selama Covid19. Jumlah sampel penelitian ini 14 perusahaan. Hipotesis penelitian diuji dengan menggunakan Partial Least Square Structural Equation Modeling dengan software SmartPLS 4.0 dan SPSS. Penelitian ini menunjukan bahwa tidak terdapat hubungann yang signifikan antara perusahaan keluarga dan leverage dengan manajemen laba. Variabel diversifikasi berpengaruh negatif terhadap manajemen laba. Variabel Good corporate governance tidak mampu memperlemah pengaruh perusahaan keluarga, diversifikasi perusahaan dan leverage terhadap manajemen laba. Sedangkan, tidak terdapat perbedaan sebelum dan selama Covid-19 terhadap leverage.
PERAN PERCEIVED VALUE DAN FREQUENCY CONSUMPTION TERHADAP REPURCHASE INTENTION KONSUMSI BUAH DI MASA PANDEMI COVID-19
Authors: Audrina Sheila Okthalia , Immanuel Dewi Mustikasari 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui pengaruh healthy consumption, perceived price fairness, perceived quality, terhadap repurchase intention konsumsi buah-buahan di tengah situasi pandemi COVID-19 dengan frequency consumption sebagai moderator dan perceived value sebagai mediator. Data kuisioner diolah dengan menggunakan PLS. Populasi dalam penelitian ini adalah masyarakat yang pernah membeli buah-buahan di Surabaya dan Sidoarjo. Teknik pengambilan sampel yang digunakan adalah purposive sampling dengan jumlah sampel sebanyak 386 responden. Hasil penelitian ini menunjukkan bahwa healthy consumption, perceived price fairness, perceived quality berpengaruh positif terhadap repurchase intention, dan perceived value memberikan efek mediasi penuh, sedangkan frequency consumption sebagai pemoderasi ditemukan memperlemah pengaruh healthy consumption terhadapa repurchase intention.
Kata kunci: Healthy consumption, frequency consumption, perceived price fairness, perceived quality, perceived value, and repurchase intention.
Contemporary European practice in transcatheter aortic valve implantation: results from the 2022 European TAVI Pathway Registry
Authors: Rosseel Liesbeth , Mylotte Darren , Cosyns Bernard , Vanhaverbeke Maarten , Zweiker David , Teles Rui Campante , Angerås Oskar , Neylon Antoinette , Rudolph Tanja Katharina , Wykrzykowska Joanna J. , Patterson Tiffany , Costa Giulia , Ojeda Soledad , Tzikas Apostolos , Abras Marcel , Leroux Lionel , Van Belle Eric , Tchétché Didier , Bleiziffer Sabine , Swaans Martin J. , Parma Radoslaw , Blackman Daniel J. , Van Mieghem Nicolas M. , Grygier Marek , Redwood Simon , Prendergast Bernard , Van Camp Guy , De Backer Ole 
Published: August 2023

BackgroundA steep rise in the use of transcatheter aortic valve implantation (TAVI) for the management of symptomatic severe aortic stenosis occurred. Minimalist TAVI procedures and streamlined patient pathways within experienced Heart Valve Centres are designed to overcome the challenges of ever-increasing procedural volume.AimsThe 2022 European TAVI Pathway Survey aims to describe contemporary TAVI practice across Europe.Materials and methodsBetween October and December 2022, TAVI operators from 32 European countries were invited to complete an online questionnaire regarding their current practice.ResultsResponses were available from 147 TAVI centres in 26 countries. In 2021, the participating centres performed a total number of 27,223 TAVI procedures, with a mean of 185 TAVI cases per centre (median 138; IQR 77–194). Treatment strategies are usually (87%) discussed at a dedicated Heart Team meeting. Transfemoral TAVI is performed with local anaesthesia only (33%), with associated conscious sedation (60%), or under general anaesthesia (7%). Primary vascular access is percutaneous transfemoral (99%) with secondary radial access (52%). After uncomplicated TAVI, patients are transferred to a high-, medium-, or low-care unit in 28%, 52%, and 20% of cases, respectively. Time to discharge is day 1 (12%), day 2 (31%), day 3 (29%), or day 4 or more (28%).ConclusionReported adoption of minimalist TAVI techniques is common among European TAVI centres, but rates of next-day discharge remain low. This survey highlights the significant progress made in refining TAVI treatment and pathways in recent years and identifies possible areas for further improvement.
‘I can’t say that anything has changed’: parents of autistic young people (16–25 years) discuss the impact of the Children and Families Act in England and Wales
Authors: Crane Laura , Davies Jade , Fritz Anne , Portman Kerrie , O’Brien Sarah , Worsley Alison , Remington Anna 
Published: August 2023

IntroductionIn 2014, changes to special educational needs and disability (SEND) legislation were introduced in England and Wales. These reforms aimed for young people and their families to receive the help and support they need, have a say regarding their support needs, and achieve better outcomes.MethodsWe examine the views of parents of autistic young people (16–25 years) regarding the impact of the reforms, several years after their introduction. In total, 115 parents of autistic young people (16–25 years) in England and Wales took part in our research: 84 completed an online survey, one took part in an interview, and 30 participated in both the survey and interview. Quantitative data, collected via the online survey, were analyzed descriptively. Qualitative data, collected via the survey and interview, were analyzed using inductive thematic analysis.ResultsParents overwhelmingly reported that their experiences had not improved since the introduction of the SEND reforms. This experience impacted their own, and their children’s, wellbeing. Parents felt that the reforms were simply delaying the inevitable, and there was still limited support for them or their children as they transitioned to adulthood.DiscussionDespite promises of a radically different system, and the potential of these reforms, parents reported that little had changed for them or their children since the introduction of the Children and Families Act.
The diagnostic effectiveness of serum sialic acid predicts both qualitative and quantitative prostate cancer in patients with prostate-specific antigen between 4 and 20 ng/mL
Authors: Sun Jingtao , Yan Lei 
Published: August 2023

IntroductionThis study aimed to evaluate the predictive value of the serum biochemical index, including alkaline phosphatase (AKP), lactate dehydrogenase (LDH), α-L-fucosidase (AFU), serum sialic acid (SA), and fibrinogen (FIB), for prostate cancer (PCa) and clinically significant prostate cancer (CSPCa) in patients with a prostate-specific antigen (PSA) value between 4 and 20 ng/mL.Patients and methodsThis study retrospectively examined the clinical data of 408 eligible patients who underwent prostate biopsies in our hospital between March 2015 and July 2022. CSPCa was defined as a “Gleason grade group of≥2”. For analyzing the association between PCa/CSPCa and serum biochemical index, univariable logistic regression and multivariable logistic regression were conducted. Based on the multivariable logistic regression model, we constructed models and compared the area under the curve (AUC). We generated the nomogram, the ROC curve, the DCA curve, and the calibration curve for PCa.ResultsOverall, we studied 271 patients with PCa (including 155 patients with CSPCa) and 137 non-PCa patients. Patients with PCa were more likely to consume alcohol, have higher total PSA (TPSA) values, and have lower free PSA (FPSA) and free/total PSA (f/T) values. There were higher TPSA values and lower f/T values in the CSPCa group when compared with the non-CSPCa group. The univariate logistic regression analyses did not show significant results. However, AKP, AFU, SA, TPSA, and FPSA all retain significant significance when all factors are included in multifactor logistic regression analysis. This finding suggests that the exposure factor exhibited an independent effect on the outcome after controlling for other factors, including the potential confounding effects that may have been underestimated. Through ROC curves, we found that SA and TPSA levels are more powerful predictors. In contrast, there is a lack of excellent predictive value for PCA and CSPCa using Age, AFU, FIB, and FPSA.ConclusionIn our study, serum biochemical index is a potential prediction tool for PCa and CSPCa for patients with PSA values between 4 and 20 ng/mL. Additionally, the new serum biochemical index SA is also useful when diagnosing PCa and CSPCa, as we conclude in our study.
Association of hypoglycaemia with the risks of arrhythmia and mortality in individuals with diabetes - a systematic review and meta-analysis
Authors: Li Gangfeng , Zhong Shuping , Wang Xingmu , Zhuge Fuyuan 
Published: August 2023

BackgroundHypoglycaemia has been linked to an increased risk of cardiac arrhythmias by causing autonomic and metabolic alterations, which may be associated with detrimental outcomes in individuals with diabetes(IWD), such as cardiovascular diseases (CVDs) and mortality, especially in multimorbid or frail people. However, such relationships in this population have not been thoroughly investigated. For this reason, we conducted a systematic review and meta-analysis.MethodsRelevant papers published on PubMed, Embase, Cochrane, Web of Knowledge, Scopus, and CINHAL complete from inception to December 22, 2022 were routinely searched without regard for language. All of the selected articles included odds ratio, hazard ratio, or relative risk statistics, as well as data for estimating the connection of hypoglycaemia with cardiac arrhythmia, CVD-induced death, or total death in IWD. Regardless of the heterogeneity assessed by the I2 statistic, pooled relative risks (RRs) and 95% confidence intervals (CI) were obtained using random-effects models.ResultsAfter deleting duplicates and closely evaluating all screened citations, we chose 60 studies with totally 5,960,224 participants for this analysis. Fourteen studies were included in the arrhythmia risk analysis, and 50 in the analysis of all-cause mortality. Hypoglycaemic patients had significantly higher risks of arrhythmia occurrence (RR 1.42, 95%CI 1.21-1.68), CVD-induced death (RR 1.59, 95% CI 1.24-2.04), and all-cause mortality (RR 1.68, 95% CI 1.49-1.90) compared to euglycaemic patients with significant heterogeneity.ConclusionHypoglycaemic individuals are more susceptible to develop cardiac arrhythmias and die, but evidence of potential causal linkages beyond statistical associations must await proof by additional specifically well planned research that controls for all potential remaining confounding factors.
Prevalence and determinants of RH alloimmunization in Rh-negative women in teaching hospitals of Addis Ababa, Ethiopia: a hospital-based cross-sectional study
Authors: Maruta Melat B. , Tesfaye Kiflom , Birhanu Esayas , Yigazu Nuradin , Yuya Mohammed , Debella Adera , Mussa Ibsa 
Published: August 2023

BackgroundDespite the implementation of immunization with an anti-D antigen for pregnant women, adverse pregnancy outcomes continue to occur in Ethiopia and most Sub-Saharan African countries. Consequently, the woman's obstetric care is compromised, and there is an increase in perinatal morbidity and mortality. In Ethiopia, the burden of the disease is not well understood, and no research has been conducted in the study area. Therefore, this study aims to determine the prevalence and determinants of Rh alloimmunization in Rh-negative women receiving care at Addis Ababa teaching hospitals.MethodsAn institutional-based cross-sectional study was conducted from 5 October 2020 to 5 May 2021, among 328 Rh-negative pregnant women who received antenatal care and delivery services at Teaching Hospitals under Addis Ababa University. Face-to-face interviews were used to gather data using a pre-tested structured questionnaire, and a chart review was performed using a checklist. The data were entered into Epidata version 3.1 and analyzed using SPSS version 22. Multivariable analysis and logistic regression were used to evaluate the predictors, and the results were presented as an adjusted odds ratio (AOR) with a 95% confidence interval. Statistical significance was declared at a p-value &lt; 0.05.ResultsAmong Rh-D negative individuals, 56(17.1%) were alloimunized with 95% CI (15.1%, 19.23%). The prevalence of Rh-D negative was 2.1% with 95% CI (1.56%, 2.76%). Factors such as unemployment [AOR = 2.28, 95% CI: 1.21, 4.28], failure to use anti-D prophylaxis in previous pregnancy [AOR = 2.08, 95% CI: 1.10, 3.92), and the presence of sensitizing events [AOR = 0.52, 95% CI: 0.27, 0.84] were statistically significant with the outcome variables.ConclusionsThis study pointed out that the prevalence of Rh was relatively large and that almost one in every five pregnant women was alloimunized. Factors such as unemployment and failure to use anti-D prophylaxis in a previous pregnancy were found to be associated with outcome variables. Therefore, all stakeholders and concerned entities should prioritize enhancing access and affordability to anti-D prophylaxis to prevent the occurrence of Rh alloimmunization and its associated adverse outcomes.
Comprehensive comparative analysis of the prognostic impact of systemic inflammation biomarkers for patients underwent cardiac surgery
Authors: Liu Zhang , Zhu Ge , Zhang Yonggui , Zhang Peng , Zang Wangfu , Shen Zile 
Published: August 2023

BackgroundInflammation plays an integral role in the development of cardiovascular disease, and few studies have identified different biomarkers to predict the prognosis of cardiac surgery. But there is a lack of reliable and valid evidence to determine the optimal systemic inflammatory biomarkers to predict prognosis.MethodsFrom December 2015 and March 2021, we collected 10 systemic inflammation biomarkers among 820 patients who underwent cardiac surgery. Time-dependent receiver operating characteristic curves (ROC) curve at different time points and C-index was compared at different time points. Kaplan–Meier method was performed to analyze overall survival (OS). Cox proportional hazard regression analyses were used to assess independent risk factors for OS. A random internal validation was conducted to confirm the effectiveness of the biomarkers.ResultsThe area under the ROC of lymphocyte-to-C-reactive protein ratio (LCR) was 0.655, 0.620 and 0.613 at 1-, 2- and 3-year respectively, and C-index of LCR for OS after cardiac surgery was 0.611, suggesting that LCR may serve as a favorable indicator for predicting the prognosis of cardiac surgery. Patients with low LCR had a higher risk of postoperative complications. Besides, Cox proportional hazard regression analyses indicated that LCR was considered as an independent risk factor of OS after cardiac surgery.ConclusionLCR shows promise as a noteworthy representative among the systemic inflammation biomarkers in predicting the prognosis of cardiac surgery. Screening for low LCR levels may help surgeons identify high-risk patients and guide perioperative management strategies.
miR-200a attenuated oxidative stress, inflammation, and apoptosis in dextran sulfate sodium-induced colitis through activation of Nrf2
Authors: Peng Shuai , Shen Lei , Yu Xiaoyun , Wu Jing , Zha Lanlan , Xia Yuan , Luo Hesheng 
Published: August 2023

IntroductionOxidative stress and inflammatory responses are critical factors in ulcerative colitis disease pathogenesis. Nuclear factor erythroid 2-related factor 2 (Nrf2) modulates oxidative stress and suppresses inflammatory responses, and the protective benefits of Nrf2 activation have been associated with the therapy of ulcerative colitis. MicroRNA-200a (miR-200a) could target Kelch-like ECH-associated protein 1 (Keap1) and activate the Nrf2-regulated antioxidant pathway. Nevertheless, whether miR-200a modulates the Keap1/Nrf2 pathway in dextran sulfate sodium (DSS)-induced colonic damage is unknown. Here, our research intends to examine the impact of miR-200a in the model of DSS-induced colitis.MethodsPrior to DSS intervention, we overexpressed miR-200a in mice for four weeks using an adeno-associated viral (AAV) vector to address this problem. ELISA detected the concentration of inflammation-related cytokines. The genes involved in inflammatory reactions and oxidative stress were identified using quantitative reverse transcription-polymerase chain reaction (qRT-PCR), western blot, and immunofluorescence. Moreover, we applied siRNAs to weakened Nrf2 expression to confirm the hypothesis that miR-200a provided protection via Nrf2.ResultsThe present study discovered miR-200a down-regulation, excessive inflammatory activation, enterocyte apoptosis, colonic dysfunction, and Keap1/Nrf2 antioxidant pathway inactivation in mouse colitis and NCM460 cells under DSS induction. However, our data demonstrated that miR-200a overexpression represses Keap1 and activates the Nrf2 antioxidant pathway, thereby alleviating these adverse alterations in animal and cellular models. Significantly, following Nrf2 deficiency, we failed to observe the protective benefits of miR-200a against colonic damage.DiscussionTaken together, through activating the Keap1/Nrf2 signaling pathway, miR-200a protected against DSS-induced colonic damage. These studies offer an innovative therapeutic approach for ulcerative colitis.