bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antipsychotic-Induced Alterations in Lipid Turnover
Authors: Pereira Sandra , Au Emily , Agarwal Sri Mahavir , Wright David C , Hahn Margaret K 
Published: January 2023

AbstractSchizophrenia is a debilitating psychiatric disorder that is treated with antipsychotics. However, despite their efficacy, antipsychotics increase the risk of metabolic disorders in a population that suffers from premature cardiovascular death. Published reports to date strongly suggest that antipsychotic-induced alterations in lipid metabolism are part of the causal relationship between antipsychotic treatment and both metabolic and cardiovascular disease. Notably, some of the adverse effects of antipsychotics on lipid metabolism are independent of antipsychotic-induced weight gain. Moreover, some antipsychotics also have beneficial effects on certain aspects of lipid metabolism. In this review, we summarize the current knowledge regarding how antipsychotics modulate lipid turnover at the whole-body, tissue, and cellular levels. We also highlight gaps in the literature, especially with respect to the intracellular mechanisms through which antipsychotics affect lipid metabolism.
hnRNPH1 establishes Sertoli–germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice
Authors: Feng Shenglei , Wen Hui , Liu Kuan , Xiong Mengneng , Li Jinmei , Gui Yiqian , Lv Chunyu , Zhang Jin , Ma Xixiang , Wang Xiaoli , Yuan Shuiqiao 
Published: January 2023

ABSTRACTSpermatogenesis depends on the crosstalk of Sertoli cells (SCs) and germ cells. However, the gene regulatory network establishing the communications between SCs and germ cells remains unclear. Here, we report that heterogeneous nuclear ribonucleoprotein H1 (hnRNPH1) in SCs is essential for the establishment of crosstalk between SCs and germ cells. Conditional knockout of hnRNPH1 in mouse SCs leads to compromised blood–testis barrier function, delayed meiotic progression, increased germ cell apoptosis, sloughing of germ cells and, eventually, infertility of mice. Mechanistically, we discovered that hnRNPH1 could interact with the splicing regulator PTBP1 in SCs to regulate the pre-mRNA alternative splicing of the target genes functionally related to cell adhesion. Interestingly, we also found hnRNPH1 could cooperate with the androgen receptor, one of the SC-specific transcription factors, to modulate the transcription level of a group of genes associated with the cell–cell junction and EGFR pathway by directly binding to the gene promoters. Collectively, our findings reveal a crucial role for hnRNPH1 in SCs during spermatogenesis and uncover a potential molecular regulatory network involving hnRNPH1 in establishing Sertoli–germ cell crosstalk.
Preferential recruitment and stabilization of Myosin II at compartment boundaries in Drosophila
Authors: Wang Jing , Michel Marcus , Bialas Lisa , Pierini Giulia , Dahmann Christian 
Published: January 2023

ABSTRACT
The regulation of mechanical tension exerted at cell junctions guides cell behavior during tissue formation and homeostasis. Cell junctions along compartment boundaries, which are lineage restrictions separating cells with different fates and functions within tissues, are characterized by increased mechanical tension compared to that of cell junctions in the bulk of the tissue. Mechanical tension depends on the actomyosin cytoskeleton; however, the mechanisms by which mechanical tension is locally increased at cell junctions along compartment boundaries remain elusive. Here, we show that non-muscle Myosin II and F-actin transiently accumulate and mechanical tension is increased at cell junctions along the forming anteroposterior compartment boundary in the Drosophila melanogaster pupal abdominal epidermis. Fluorescence recovery after photobleaching experiments showed that Myosin II accumulation correlated with its increased stabilization at these junctions. Moreover, photoconversion experiments indicated that Myosin II is preferentially recruited within cells to junctions along the compartment boundary. Our results indicate that the preferential recruitment and stabilization of Myosin II contribute to the initial build-up of mechanical tension at compartment boundaries.
Comparing the predictive values of procalcitonin/albumin ratio and other inflammatory markers in determining COVID-19 severity
Authors: Damar Çakırca Tuba , Çakırca Gökhan , Torun Ayşe , Bindal Ahmet , Üstünel Murat , Kaya Ahmet 
Published: January 2023

Objective: To examine the relationship between COVID-19 severity and procalcitonin/albumin ratio (PAR) and compare the PAR with oft-reported inflammatory markers, including procalcitonin, white blood cell (WBC), neutrophil/lymphocyte ratio (NLR) and C-reactive protein (CRP).
Methods: In this retrospective research study conducted at Sanliurfa Training and Research Hospital during May to September 2020; total, 577 adult subjects diagnosed with COVID-19 were included and categorized into two groups based on place of hospitalization: the intensive care unit (ICU) group (n=151) and the general ward (GW) group (n=426). Laboratory test results and demographic characteristics of the subjects were recorded.
Results: PAR, NLR, CRP, WBC, neutrophil and procalcitonin values were markedly higher in the ICU group than in the GW group. On the contrary, lymphocyte count and albumin level were markedly lower. PAR showed positive correlations with WBC, NLR, and CRP. Multivariate analysis showed that advanced age, presence of hypertension, elevated PAR, WBC, NLR, urea and lactate dehydrogenase levels were independent risk factors associated with the need for intensive care in COVID-19 subjects. Among them, the PAR showed the highest odds ratio (5.564) for ICU admission. Additionally, the area under the ROC curve of the PAR (0.888) was markedly greater than that of WBC (0.777), NLR (0.822), CRP (0.842) and procalcitonin (0.870).
Conclusions: This study revealed that PAR was superior to procalcitonin, WBC, NLR and CRP in determining COVID-19 severity. PAR was an important predictor of ICU requirement in COVID-19 cases.
doi: https://doi.org/10.12669/pjms.39.2.6856
How to cite this: Damar Çakırca T, Çakırca G, Torun A, Bindal A, Üstünel M, Kaya A. Comparing the predictive values of procalcitonin/albumin ratio and other inflammatory markers in determining COVID-19 severity. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6856
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Kingdom Fungi capabilities as materials for design
Authors: Perez Rodriguez Carolina , Ayala-Garcia Camilo , Rognoli Valentina 
Published: January 2023

Background: Living organisms such as algae, bacteria, and fungi are used to construct novel materials that offer possibilities for innovation. The article aims to explore mycelial growth and analyze the necessary conditions for its development and durability showing its visual potential as a material to be included in a design project. We have explored the aesthetic and metabolic opportunities of the Fungi Kingdom for the design and production of new materials. Methods: Taking the processes that are commonly implemented in biology and by adopting them into design processes, we grow filamentous fungi and isolate them in pieces designed to show and guarantee their natural development, exposing themselves to stress variables such as temperature, humidity, and substrate, among others. Results: Perpetuity is evident after nine years of cultivation; the colonies remain in the container preserving their morphological character and the pigmentation presented from the beginning of incubation with a slight variation in the saturation of the colors. Conclusions: Depending on the species of fungi used and the stimuli applied by the designer, a wide variety of textures, shapes, and colors can be propitiated, generating new product languages and artifacts where their aesthetic qualities are maintained over time.
EPIDEMIOLOGICAL PREDICTION OF INTESTINAL INFECTION CAUSED BY SOME NON-POLIOENTEROVIRUSES OF COXSACKIE GROUP A AMONG THE POPULATION OF AZERBAIJAN FOR 2015–2024
Authors: Rustamova Lala I. 
Published: January 2023

Background. Despite significant achievements in research and diagnostic practice, as well as in the field of Molecular and Biological Technology, the problem of non-polioenterovirus infections is still at the stage of serious research.
Purpose. The purpose of the study epidemiological prevalense for some non-polioenteroviruses of Coxsackie group A among the population of Azerbaijan for 2015-2024.
Materials and methods. In the study, the period of some non-polioenteroviruses belonging to Coxsackie group A – KA18, KA20 and KA21 serotypes was confirmed by polymerase chain reaction among the population in Baku during 2006-2010.
The study was affirmed by design-descriptively; by method – clinically; by volume – by generalization; by type – scientifically; by material – retrospectively and prospectively; by term – transversely; by place – clinically.
Statistical analysis was carried out in MS EXCELL-2019 and IBM Statistics SPSS-26 using determinant and regression methods (ARIMA).
Results. On the basis of results of study the statistical reliability of prognostic model showing prediction of stabil appearing level of intestinal infection caused by some non-polioenteroviruses of Coxsackie group A (KA18, KA20 and KA21) among the child population of Azerbaijan for 2015-2024 have been determined.
Practical implications. The results of investigation show the advisability of the using of ARIMA models for epidemiological prediction of intestinal infection caused by Coxsackie group A among the population in Azerbaijan.
Handling with care
Authors: Sharma Priya 
Published: January 2023

Priya Sharma examines the importance of seamless complaints handling, and how best to utilise communication skills. Aim The reader should be able to understand the key components of effective complaints handling. Objectives To have an overview of the General Dental Council's regulatory requirements for handling complaints To appreciate the importance of professional complaints handling To understand how communication skills (verbal, written and non-verbal) are of primary importance
Chiral metasurfaces in anisotropic thin film lithium niobate and its nonlinear effect
Authors: Lv Xianpeng , Wu Shuyao , Tian Ziping , Li Yang , Yang Tiefeng , Qiu Wentao , Guan Heyuan , Lu Huihui 
Published: January 2023

Different from conventional two-dimensional photonic metasurfaces, chiral photonic metasurfaces, which are composed of a chiral pattern with subwavelength dimensions, exhibit different chiroptical physical phenomena, such as spin-preserving, nonlinear chiroptical effects, and optical vortex generation. However, the effect of symmetry in the vertical direction on the linear and nonlinear response of the chiral quasi-two-dimensional metasurface has been seldom reported. In this study, we design and simulate a chiral metasurface using topological patterns in lithium niobate (LN) thin film to obtain the optimal circular dichroism and its corresponding nonlinear effect. Triangular holes with a certain rotation constitute a quasi-two-dimensional metasurface, which possesses outstanding chirality for the spin state of light, thus allowing it to control linear and nonlinear chiralities. The nonlinear conversion efficiency ηSHG reaches 2×10−4 and 4×10−3 on the LN structure with substrate and without substrate, respectively. Nonlinear circular dichroism CDSHG is 5.8 dB at 783 nm on a SiO2 substrate. This tunable chiral metasurface is expected to be applicable to nonlinear chiroptical responses and chiral light modulation.
Cytogenetic Analysis in Patients with Azoospermia
Authors: Asja Begovac  , Mirela Mačkić-Đurović  , Aganović-Mušinović  
Published: January 2023

BACKGROUND
Azoospermia (the absence of sperm in the semen) significantly amounts to infertility in men (15 % of infertile men). Since genetics plays a huge part in its origin, genetic testing needs to be considered as an important part of early diagnostics when evaluating azoospermic patients. The aim of our study was to determine the genetic cause of azoospermia, to analyze karyograms and the possible presence of Y chromosome microdeletion.
METHODS
The study included 20 men diagnosed with azoospermia. The oldest male was 50 and the youngest was 24 years old. They were sent for analysis of karyotype and microdeletions of the Y chromosome (AZF region) to the Center for Genetics of the Faculty of Medicine.
RESULTS
The results of the cytogenetic analysis showed 3/20 (15 %) of abnormal karyotypes. Three patients were identified with two different translocations that were not previously reported. Two brothers were identified with the same translocation between the short arm of chromosome 8 and the long arm of chromosome 17 [46, XY, t(8;17)(p23;q11)], after both of them had failed in-vitro fertilization (IVF). The third patient with chromosomal translocation between the short arm of chromosome 4 and the long arm of chromosome 11 [46, XY, t(4;11)(p16;q13)]. Molecular genetic analysis showed no Y chromosome microdeletion in any of these three cases. However, from the rest of the group, only one patient had Y chromosome microdeletion in the AZFc region (one of the most common causes of genetic azoospermia). His karyotype was normal.
CONCLUSIONS
Our study confirms that cytogenetic and molecular genetic analysis plays an important role in identifying the cause of azoospermia. Genetic counseling should be provided when these abnormalities are identified before making any future medical decisions.
Motivos para salir y retornar a México: El caso de científicos(as) repatriados(as) (1991-2019)
Authors: García-Pascacio Luis Enrique , Yurén Camarena Teresa , Ramírez Pérez Jorge Ariel , Espinosa Meléndez Julieta 
Published: January 2023

Este trabajo tiene como objetivo explicar los motivos que tuvieron 32 investigadores(as) para salir al extranjero y retornar a México en el marco del programa de repatriación del CONACYT. La perspectiva de Bernard Lahire sobre socialización resultó útil porque permite ver los recorridos biográficos de los individuos al momento de formar parte de ciertos grupos o instituciones. Recurrimos al método biográfico para poder captar los procesos de socialización. La perspectiva de Lahire se complementa con la categoría contextos de recepción que permite leer teóricamente la dinámica de la repatriación y a su vez entender los motivos para salir y retornar. Si bien existe una política que incentiva el retorno, son los grupos de investigación e instituciones quienes determinan el retorno.
Existence and multiplicity of solutions for a new p(x)-Kirchhoff problem with variable exponents
Authors: Chu Changmu , Xie Yanling , Zhou Dizhi 
Published: January 2023

Abstract
In this article, we study a class of new p(x)-Kirchhoff problem without satisfying the Ambrosetti-Rabinowitz type growth condition. Under some suitable superliner conditions, we introduce new methods to show the boundedness of Cerami sequences. By using the mountain pass lemma and the symmetric mountain pass lemma, we prove that the p(x)-Kirchhoff problem has a nontrivial weak solution and infinitely many solutions.
Coding for Initial Newborn Care
Authors:   American Academy of Pediatrics
Published: January 2023

This article reviews the codes and reporting guidelines for initial newborn care services, including the following:
Attendance at delivery and newborn resuscitation Initial care of the normal newborn Initial hospital care of a sick newborn Initial neonatal intensive care Initial neonatal critical care A brief discussion of how code edits used by many payers affect reporting and payment is also provided.
Evaluation of Silybum marianum seed extract and vitamin B6 derivatives on methylglyoxal and sugar-induced oxidative DNA damage
Authors: İnceören N. , Çeken Toptancı B. , Kızıl G. , Kızıl M. 
Published: January 2023

AbstractReducing sugars are known to generate reactive oxygen species (ROS), mainly by means of the glycation reaction. The hydroxyl radical, a prominent entity of ROS, is known to alter cellular DNA and induces damage to DNA, and plays a role in diseases such as diabetes mellitus. In this study, the oxidative damage of DNA induced by the lysine/Fe3+/MG reaction was investigated. Silybum marianum seeds extract (SlyE), standard silymarin (Sly), and vitamin B6 derivatives, pyridoxal-5-phosphate (PLP), pyridoxamine (PM), and pyridoxine (P) in reversing glycation-induced damage in DNA were evaluated. In addition, different sugars and sugar phosphates were incubated with plasmid pBR 322 DNA to control and compare their harmful effects. Our results revealed that SlyE protected lysine/Fe3+/MG induced oxidative DNA damage more effectively than Sly. Vitamins, on the other hand, prevented this DNA damage in the order of PLP>P>PM. The DNA altering and damaging intensity of sugars and sugar phosphates tested increased considerably in the following order: Ribose-5-phosphate > fructose-6-phosphate > ribose > fructose > fructose-1,6 biphosphate > glucose-6 phosphate > glucose. The results show that the lysine/Fe3+/MG glycation reaction can cause oxidative damage of DNA through a mechanism involving hydroxyl radicals. It also provides evidence that ribose-5-phosphate and fructose and its phosphate metabolites can alter DNA more rapidly in vitro than glucose and its phosphate metabolites.
Maternal Characteristics and Complications in Pregnancies Complicated with Diabetes
Authors: ÇELİK Mehmet , GÜLER Abdül Hamid 
Published: January 2023

Abstract
Aim: Pregnancies complicated with diabetes are risky pregnancies with different maternal characteristics and increased maternal complications compared to the normal pregnant group. In this study, it is aimed to determine maternal characteristics and maternal complications in pregnant women with different glucose intolerance or blood glucose levels, and to compare them with the information in the literature and to investigate the effectiveness of our follow-up and treatment protocols.
Material and Method: This study is carried out with 223 patients at Ümraniye Training and Research Hospital between May 2009 and March 2010. Group 1 in the study, normal glycemic group; Group 2, group with 1 value higher in 100 g oral glucose tolerance test (OGTT); Group 3, gestational diabetes mellitus (GDM), is the blood sugar regulated group; Group 4, the uncontrolled group diagnosed with GDM and whose blood sugar is not regulated; Group 5 consisted of patients with pregestational diabetes mellitus, with or without regulated blood sugar.
Results: Considering the maternal characteristics, it is seen that the age, gravida, parity, body mass index (BMI) of Group 3, Group 4 and Group 5 patients are significantly higher than the patients in Group 1 and Group 2. The rates of preeclampsia, macrosomic baby and preterm birth are significantly higher in groups 4 and 5. In terms of delivery types, normal birth rate is high in Group 1, while cesarean section rates are high in Groups 4 and 5. According to the groups, the cases with a 1st minute apgar score less than 7 are significantly higher in Group 4 and Group 5.
Conclusion: It is revealed that different glucose intolerances cause some problems in pregnancy, increase complications, and uncontrolled blood glucose levels increase these problems and complications. In pregestational and gestational periods; In such cases, it should be aimed and ensured that these problems and complications are reduced to the lowest possible level with appropriate diagnosis and treatment approaches.
Assessment of Mothers' Mood and Cognition Functions in Perinatal Period and Their Influences on Breastfeeding Success
Authors: GÜLER SÖNMEZ Tuğba , ALTUNTAŞ Nilgün , AKSU Muhammed Hakan , ALTUNTAŞ Serra , ÜNSAL Ayşe , BAHÇECİTAPAR Melike , BAĞCI Hamit Harun , FİDANCI İzzet , ÇELİK Pinar 
Published: January 2023

Aim: In this study, we aimed to examine the effects of peripartum mother's cognitive functioning, anxiety, and postpartum depression of mothers on the practice of exclusive breastfeeding.
Material and Method: The pregnant women in the last trimester who were attended in the outpatient department of obstetrics and gynecology were included in the study as the study group. A total of three follow-ups were conducted in the study group. In our study Mini-Mental State Examination (MMSE) was used to assess cognitive functioning, State-Trait Anxiety Inventory (STAI) 1,2 to assess anxiety, Edinburgh Postnatal Depression Scale (EPDS) to assess postpartum depression, Breastfeeding Self-Efficacy Scale (BSES) to assess mother's self- efficacy in breastfeeding, LATCH Breastfeeding Assessment Tool to assess mother's and baby's breastfeeding technique.
Results: All of 158 pregnant and 96 non-pregnant women were enrolled in the study. After delivery, there was a significant decrease in STAI 2 scores compared to the prenatal period (p=0.001) and a significant increase in MMSE scores (p=0.001). There was no difference in STAI 1,2 , and MMSE scores between the groups with and without successful breastfeeding (p >0.05). LATCH scores were statistically significantly higher in the group that successfully breastfed (p =0.001). LATCH (r=-0.427, p
Cystic Echinococcosis in Children: Ten Years of Experience and Which Laboratory Result in Evaluating Ruptured Cases?
Authors: SALMAN Hakan , SALMAN Zeliha , KART Yeliz , AKÇAM Mustafa 
Published: January 2023

Aim
Hydatid disease (Echinococcosis) is a common zoonosis in countries that are involved in livestock such as our country. Our study aims to evaluate pediatric cases with hydatid disease over the last decade in our region and to determine the significance of initial clinical and laboratory findings in distinguishing ruptured hydatid cyst cases.
Materials and Methods
A retrospective analysis was made on demographic characteristics, presenting symptoms, physical examination, laboratory and radiological findings, and treatments of children with hydatid disease who were treated in our hospital and followed up regularly between January 2011 and December 2020.
Results
The study sample of 42 cases included 19 (45.2%) girls, with a median age of 125.5 (34-209) months. The most common symptom was abdominal pain (50%), and the most common physical examination finding was decreased breath sounds (23.8%). Thirty-five (83.3%) patients had single organ involvement and 7 (16.7) patients had multiple organ involvement. Cysts were detected in the right lobe of the liver in 24 (75%) of hepatic hydatid cysts and the left lobe in 7 (58.3%) of pulmonary hydatid cysts. The median size of the cysts was 57.5 (12-140) mm. The initial IHA titer, eosinophil count, eosinophil percentage, and sedimentation value were statistically significantly higher in patients with ruptured cysts than in those without rupture (p= 0.002, p= 0.003, p= 0.003, p= 0.02, respectively).
Conclusions
Initial pathological examination findings and at initial laboratory findings such as high IHA titer, eosinophil count, eosinophil percentage, sedimentation value can be used to distinguish rupture cases.