bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paradigm constraints on moral decision‐making dynamics
Authors: Gautheron Flora , Quinton Jean‐Charles , Muller Dominique , Smeding Annique 
Published: March 2023

AbstractInvestigating decision making with two‐alternative forced choice (2AFC) tasks may artificially constrain decisions, especially in the moral domain where we may want to express nuance. We aimed at examining whether paradigm constraints—that is, binary (as in 2AFC tasks) versus continuous response mode—constrained early decision‐making dynamics, as traceable in mouse movements. In the moral domain, long sentences are often used, and we therefore developed a new mouse‐tracking design adapted to long‐to‐process stimuli while also introducing mouse‐tracking‐compatible continuous response scales. Two preregistered studies, with adapted (Study 1) and newly designed (Study 2) mouse‐tracking paradigms tested how trajectories differed between response modes from an early stage onwards. Overall, findings provide evidence consistent with hypothesis, ruling out alternative explanations in terms of motor planning, hence questioning the prevalence of 2AFC tasks in decision‐making research. Discussion further focuses on paradigmatic challenges addressed by the present research and basic contributions regarding the bidirectional influences between ongoing actions and decisions.
Benefits of co‐translational complex assembly for cellular fitness
Authors: Khan Krishnendu , Fox Paul L. 
Published: March 2023

AbstractComplexes of two or more proteins form many, if not most, of the intracellular “machines” that execute physical and chemical work, and transmit information. Complexes can form from stochastic post‐translational interactions of fully formed proteins, but recent attention has shifted to co‐translational interactions in which the most common mechanism involves binding of a mature constituent to an incomplete polypeptide emerging from a translating ribosome. Studies in yeast have revealed co‐translational interactions during formation of multiple major complexes, and together with recent mammalian cell studies, suggest widespread utilization of the mechanism. These translation‐dependent interactions can involve a single or multiple mRNA templates, can be uni‐ or bi‐directional, and can use multi‐protein sub‐complexes as a binding component. Here, we discuss benefits of co‐translational complex assembly including accuracy and efficiency, overcoming hidden interfaces, localized and hierarchical assembly, and reduction of orphan protein degradation, toxicity, and dominant‐negative pathogenesis, all serving to improve cell fitness.
Progressive alterations in white matter microstructure across the timecourse of Huntington's disease
Authors: Estevez‐Fraga Carlos , Elmalem Michael S. , Papoutsi Marina , Durr Alexandra , Rees Elin M. , Hobbs Nicola Z. , Roos Raymund A. C. , Landwehrmeyer Bernhard , Leavitt Blair R. , Langbehn Douglas R. , Scahill Rachael I. , Rees Geraint , Tabrizi Sarah J. , Gregory Sarah 
Published: March 2023

AbstractBackgroundWhole‐brain longitudinal diffusion studies are crucial to examine changes in structural connectivity in neurodegeneration. Here, we investigated the longitudinal alterations in white matter (WM) microstructure across the timecourse of Huntington's disease (HD).MethodsWe examined changes in WM microstructure from premanifest to early manifest disease, using data from two cohorts with different disease burden. The TrackOn‐HD study included 67 controls, 67 premanifest, and 10 early manifest HD (baseline and 24‐month data); the PADDINGTON study included 33 controls and 49 early manifest HD (baseline and 15‐month data). Longitudinal changes in fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity, and radial diffusivity from baseline to last study visit were investigated for each cohort using tract‐based spatial statistics. An optimized pipeline was employed to generate participant‐specific templates to which diffusion tensor imaging maps were registered and change maps were calculated. We examined longitudinal differences between HD expansion‐carriers and controls, and correlations with clinical scores, including the composite UHDRS (cUHDRS).ResultsHD expansion‐carriers from TrackOn‐HD, with lower disease burden, showed a significant longitudinal decline in FA in the left superior longitudinal fasciculus and an increase in MD across subcortical WM tracts compared to controls, while in manifest HD participants from PADDINGTON, there were significant widespread longitudinal increases in diffusivity compared to controls. Baseline scores in clinical scales including the cUHDRS predicted WM microstructural change in HD expansion‐carriers.ConclusionThe present study showed significant longitudinal changes in WM microstructure across the HD timecourse. Changes were evident in larger WM areas and across more metrics as the disease advanced, suggesting a progressive alteration of WM microstructure with disease evolution.
Assessing the impact of corporate environmental performance on efficiency improvement in labor investment
Authors: Li Weiping , Chen Sihan , Gao Zhuxin , Chen Xiaoqi 
Published: March 2023

AbstractEnvironmental, social, and governance (ESG) factors have become increasingly important to employees and companies alike. It is important to integrate ESG considerations into labor investment decisions. We examine the impact of ESG performance on firms' labor investment efficiency. Using data from A‐share listed firms from 2015 to 2020, we find that ESG performance improves labor investment efficiency. Such positive effect is robust after using alternative measures for labor investment efficiency and ESG performance, alternative regression specifications, and a bunch of endogeneity tests. The mechanism tests show that a strong ESG record can reduce financial constraints and improve the information environment, thus subsequently boosting the efficiency of labor investment. The findings of the study shed light on efficiency improvement in labor investment for management, regulatory authority, and environmental activists.
Pyrazolopyrimidinone Based Selective Inhibitors of PDE5 for the Treatment of Erectile Dysfunction
Authors: Hudwekar Abhinandan D. , Kotwal Pankul , Dar Mohd. Ishaq , Balgotra Shilpi , Dogra Ashish , Kour Jaspreet , Chobe Santosh S. , Nandi Utpal , Hussain Syed Sajad , Sawant Sanghapal D. 
Published: March 2023

AbstractContinuing research with our earlier finding of sildenafil based analogs in the search of new inhibitors of PDE5 for erectile dysfunction suggested that there is a scope of modifications at N‐methylpiperazine ring with hydrophobic region followed by hydrogen bond donor or acceptor region. However, the leads identified earlier had some limitations like poor pharmacokinetic (PK) profile, low aqueous solubility and poor bioavailability. In this direction, a new series of sildenafil based analogs were designed, synthesized and screened for their PDE5 inhibitory activity. In this series compound 18 was found to have excellent in vitro activity with selectivity towards PDE5 isozyme, also the in vivo activity and pharmacokinetic profile was excellent. The cyp inhibition and CaCO2 permeability was also excellent for compound 18.
Synthesis and Characterization of New Lutidinium Ionic Liquid‐Supported Vanadylsalicylaldoxime Complex for Catalytic Application in Epoxidation Reaction
Authors: Elshaarawy Reda F. M. , Abdel Gawad Hamad H. , Hassan Hassan M. A. , Abd Alaal Reda M. , Hassan Eman M. , Yahya Rana O. , Ismail Lamia A. 
Published: March 2023

AbstractA new chelating task‐specific ionic liquid (TSIL), lutidinium‐based salicylaldoxime (LSOH), and its square pyramidal vanadyl(II) complex (VO(LSO)2) have been successfully synthesized and structurally characterized using elemental (CHN), spectral, and thermal analyses. The catalytic activity of the lutidinium‐salicylaldoxime complex (VO(LSO)2) in the alkene epoxidation reactions was studied under various reaction conditions, such as solvent effect, alkene/oxidant molar ratio, pH, reaction temperature, reaction time, and the catalyst dose. The results demonstrated that the CHCl3 solvent, 1 : 3 of the cyclohexene/H2O2 ratio, pH 8, temperature of 340 K, and catalyst dose of 0.012 mmol are assigned as the optimum conditions for achieving maximum catalytic activity for VO(LSO)2. Moreover, the VO(LSO)2 complex has the potential for application in the effective and selective epoxidation of alkenes. Notably, under optimal VO(LSO)2 conditions, cyclic alkenes convert more efficiently to their corresponding epoxides than linear alkenes.
Two‐Step Validation Approach for Tools To Study the DNA Repair Enzyme SNM1A
Authors: Fay Ellen M. , Newton Ailish , Berney Mark , El‐Sagheer Afaf H. , Brown Tom , McGouran Joanna F. 
Published: March 2023

AbstractWe report a two‐step validation approach to evaluate the suitability of metal‐binding groups for targeting DNA damage‐repair metalloenzymes using model enzyme SNM1A. A fragment‐based screening approach was first used to identify metal‐binding fragments suitable for targeting the enzyme. Effective fragments were then incorporated into oligonucleotides using the copper‐catalysed azide–alkyne cycloaddition reaction. These modified oligonucleotides were recognised by SNM1A at >1000‐fold lower concentrations than their fragment counterparts. The exonuclease SNM1A is a key enzyme involved in the repair of interstrand crosslinks, a highly cytotoxic form of DNA damage. However, SNM1A and other enzymes of this class are poorly understood, as there is a lack of tools available to facilitate their study. Our novel approach of incorporating functional fragments into oligonucleotides is broadly applicable to generating modified oligonucleotide structures with high affinity for DNA damage‐repair enzymes.
A step‐growth strategy to grow vertical porous aromatic framework nanosheets on graphene oxide: Hybrid material‐confined Co for ammonia borane methanolysis
Authors: Li Xiugang , Yao Qilu , Shi Rongwei , Huang Minsong , Lu Zhang‐Hui 
Published: March 2023

AbstractThe rational synthesis of a two‐dimensional (2D) porous aromatic framework (PAF) with a controllable growth direction remains a challenge to overcome the limitation of traditional stacked 2D materials. Herein, a step‐growth strategy is developed to fabricate a vertically oriented nitrogen‐rich porous aromatic framework on graphene oxide (V‐PAF‐GO) using monolayer benzidine‐functionalized GO (BZ‐GO) as a molecular pillar. Then, the confined Co nanoparticle (NP) catalysts are synthesized by encapsulating ultra‐small Co into the slit pores of V‐PAF‐GO. Due to the high nitrogen content, large specific surface area, and adequate slit pores, the optimized vertical nanocomposites V‐PAF‐GO provide abundant anchoring sites for metal NPs, leading to ultrafine Co NPs (1.4 nm). The resultant Co/V‐PAF‐GO catalyst shows an extraordinary catalytic activity for ammonia borane (AB) methanolysis, yielding a turnover frequency value of 47.6 min−1 at 25°C, comparable to the most effective non‐noble‐metal catalysts ever reported for AB methanolysis. Experimental and density functional theory studies demonstrate that the electron‐donating effect of N species of PAF positively corresponds to the low barrier in methanol molecule activation, and the cleavage of the O–H bond in CH3OH has been proven to be the rate‐determining step for AB methanolysis. This work presents a versatile step‐growth strategy to prepare a vertically oriented PAF on GO to solve the stacking problem of 2D materials, which will be used to fabricate other novel 2D or 2D–2D materials with controllable orientation for various applications.
HAV‐Peptides Attached to Colloidal Probes Faithfully Detect E‐Cadherins Displayed on Living Cells
Authors: Toy Silan , Dietz Jörn , Naumann Peter , Trothe Janina , Thomas Franziska , Diederichsen Ulf , Steinem Claudia , Janshoff Andreas 
Published: March 2023

AbstractCell adhesion molecules are crucial for a variety of biological processes, including wound healing, barrier formation and tissue homeostasis. One of them is E‐cadherin which is generally found at adherent junctions between epithelial cells. To identify this molecule on the surface of cells, E‐cadherin mimetic peptides with a critical amino acid sequence of HAV (histidine‐alanine‐valine) were synthesized and attached to solid‐supported membranes covering colloidal probes. Two different functionalization strategies were established, one based on the complexation of DOGS‐NTA(Ni) with a polyhistidine‐tagged HAV‐peptide and the other one relying on the formation of a HAV‐lipopeptide using in situ maleimide‐thiol coupling. Binding studies were performed to verify the ability of the peptides to attach to the membrane surface. Compared to the non‐covalent attachment via the His‐tag, we achieved a higher yield by lipopeptide formation. Colloidal probes functionalized with HAV‐peptides were employed to measure the presence of E‐cadherins on living cells either using video particle tracking or force spectroscopy. Here, human HaCaT cells were examined confirming the specific interaction of the HAV‐peptide with the E‐cadherin of the cells. Statistical methods were also used to determine the number of single‐bond ruptures and the force of a single bond. These findings may be essential for the development of novel biosynthetic materials given their potential to become increasingly relevant in medical applications.
Hydrogen Bonding Parameters by Rapid Colorimetric Assessment: Evaluation of Structural Components Found in Biological Ligands and Organocatalysts
Authors: Roenfanz Hanna F. , Paniak Thomas J. , Berlin Cameron B. , Tran Van , Francisco Karol R. , Lassalas Pierrik , Devas Anisha , Landes Olivia , Rosenberger Avalon , Rotella Madeline E. , Ballatore Carlo , Kozlowski Marisa C. 
Published: March 2023

AbstractHydrogen bonding is a key molecular interaction in biological processes, drug delivery, and catalysis. This report describes a high throughput UV‐Vis spectroscopic method to measure hydrogen bonding capacity using a pyrazinone sensor. This colormetric sensor reversibly binds to a hydrogen bond donor, resulting in a blue shift as additional equivalents of donor are added. Titration with excess equivalents of donor is used to determine the binding coefficient, ln(Keq). Over 100 titrations were performed for a variety of biologically relevant compounds. This data enabled development a multiple linear regression model that is capable of predicting 95 % of ln(Keq) values within 1 unit, allowing for the estimation of hydrogen bonding affinity from a single measurement. To show the effectiveness of the single point measurements, hydrogen bond strengths were obtained for a set of carboxylic acid bioisosteres. The values from the single point measurements were validated with full titrations.
Traceless N‐Polyfluoroalkylation of Weakly Nucleophilic Nitrogen Containing Compounds
Authors: Santos Laura , Audet Florian , Donnard Morgan , Panossian Armen , Vors Jean‐Pierre , Bernier David , Pazenok Sergii , Leroux Frédéric R. 
Published: March 2023

AbstractHere we report an efficient access to high‐value N‐polyfluoroalkyl anilines, primary polyfluoroalkylamines and N,N‐bis(polyfluoroalkyl)amines, via N‐polyfluoroalkylation of sulfonamides and phthalimide derivatives using sulfuryl fluoride (SO2F2). The in situ formation of polyfluoroalkyl fluorosulfonates from commercially available fluorinated alcohols and economical sulfuryl fluoride is highly advantageous given that some polyfluoroalkyl halides are ozone‐depleting substances (ODS) regulated by the Montreal protocol. This general method is applied to the polyfluoroalkylation of a variety of sulfonamides, N‐sulfonyl carbamates and phthalimide with a wide tolerance of functional groups. The process thus provides viable access for industry to N‐(polyfluoroalkyl)anilines as well as primary and secondary N‐(polyfluoroalkyl)amines, which are very valuable but not easily accessible building blocks for life science applications.
Tamoxifen use and risk of endometrial cancer in breast cancer patients: A systematic review and dose–response meta‐analysis
Authors: Ghanavati Matin , Khorshidi Yasaman , Shadnoush Mahdi , Akbari Mohammad Esmaeil , Ardehali Seyed Hossein , Chavarri‐Guerra Yanin , Akbari Atieh , Barragan‐Carrillo Regina , Amin Amlashi Manoochehr , Javid Zeinab , Rahmani Jamal 
Published: March 2023

AbstractBackgroundWorse prognosis of endometrial cancers (EC) in tamoxifen‐treated women compared to non‐tamoxifen‐treated women been proposed. The relationship between tamoxifen treatment of breast cancer (BC) and the risk of EC is controversial and there is no agreement between publication results on this issue (the answer to all comments provided in the page 2 of manuscript). The aim of this study is investigation the association between tamoxifen treatment and the risk of EC in patients with BC.Methods and ResultsWe conducted a comprehensive search with related keywords in MEDLINE/PubMed, SCOPUS, and Web of Science databases until April 16, 2022. Random‐effects model (DerSimonian and Laird) was used to pool risk ratios (RRs) with 95% confidence intervals (CIs) of EC. Dose, cumulative dose, and duration‐response analysis were performed in linear and non‐linear states. Twenty‐six studies reported a relation between tamoxifen treatment and risk of EC in patients with BC. Results showed a direct relationship between tamoxifen use and EC (RR: 2.03, 95% CI: 1.68–2.45; I2:76%). By increase the age of participants, the risk of EC was decrease (coef = −.0206), although this was not statistically significant (p = .37). Linear dose–response model indicated a direct significant association between dose and duration use of tamoxifen and EC (dose: exe(b) = 1.019, p = .001; duration: exe(b) = 1.014, p = .001). Non‐linear dose–response analysis confirmed linear analysis.ConclusionThis study highlights that tamoxifen use is a significant risk factor related to the incidence of EC in patients with BC.
Attachment in individuals with eating disorders compared to community controls: A systematic review and meta‐analysis
Authors: Jewell Tom , Apostolidou Eleni , Sadikovic Kevser , Tahta‐Wraith Kirsty , Liston Sarah , Simic Mima , Eisler Ivan , Fonagy Peter , Yorke Isabel 
Published: March 2023

AbstractObjectiveIndividuals with eating disorders are known to have higher rates of insecure attachment compared to community controls, but the factors underlying this finding are poorly understood. We conducted the first meta‐analysis comparing attachment in eating disorder samples compared to community controls that included quality assessment, publication bias and moderation analysis.MethodWe pre‐registered our meta‐analysis (CRD42019146799) and followed PRISMA guidelines. We searched PsychINFO, Embase, Medline, CINAHL, and Scopus for publications. Attachment scores were extracted, and Cohen's d calculated for each study using a random effects model.ResultsIn total, 35 studies were included in the meta‐analysis and six studies were summarized in a narrative review. Eating disorder samples showed higher rates of insecure attachment compared to community controls, with a large effect size, across measurement methods and different attachment dimensions. Blinding of assessors moderated effect sizes for attachment interview studies, but no other moderators were significant.DiscussionRisk of insecure attachment is elevated in individuals with eating disorders, albeit heterogeneity is high and largely unexplained. Clinicians may need to take this into account in their work, particularly given the association between attachment insecurity and challenges to therapeutic alliance. Future studies comparing eating disorder samples with community samples should control for general psychopathology.Public SignificanceAttachment is a broad concept referring to a person's thoughts, feelings and behaviors in relation to close others. This systematic review and meta‐analysis found that individuals with eating disorders are lower in attachment security than community controls, regardless of attachment construct or measurement approach. Attachment may be relevant in influencing eating disorder recovery, the development of therapeutic alliance, and potentially clinical outcomes, although more research is needed.
The Inhibitory Effect of Gallic Acid Alkyl Esters on Lipid Oxidation of Intactly Soaked Oyster Meats and Oyster Meat Homogenates during Refrigerated Storage
Authors: Luo Ying , Zhao Guan‐Hua , Pei Xue‐Chen , Yin Fa‐Wen , Liu Hui‐Lin , Qin Lei , Zhou Da‐Yong 
Published: March 2023

AbstractIn this study, the antioxidant effects of gallic acid (GA) and its alkyl esters including methyl gallate (MG), butyl gallate (BG), octyl gallate (OG), and lauryl gallate (LG) in whole oyster meats and oyster meat homogenates during cold storage are investigated. The oxidation degree of lipid is measured by peroxide value (POV), thiobarbituric acid active substances (TBARS), and polyunsaturated fatty acid (PUFA) percentage. The results show that the lipid oxidation in the two types of samples is inhibited by GA alkyl esters, and the antioxidant effects first increase and then decrease along with the extension of the chain length, among the esters, BG and OG are relatively more effective. Therefore, it is speculated that the antioxidant capacity of GA alkyl esters may be influenced by hydrophobicity and follows a “cut‐off effect” in whole oyster meats and oyster meat homogenates.Practical application: Seafood is easily oxidized even under cold storage because it contains more PUFA. Antioxidants are widely used to inhibit lipid oxidation. In this study, the antioxidant capacity of GA alkyl esters in whole oyster meats and oyster meat homogenates is investigated, which improves the selection of suitable antioxidants to strengthen the oxidation stability of oyster samples for cold storage.
The Oxidation of Organo‐Boron Compounds Using Electrochemically Generated Peroxodicarbonate
Authors: Kohlpaintner Philipp J. , Marquart Lucas , Gooßen Lukas J. , Waldvogel Siegfried R. 
Published: March 2023

AbstractPeroxodicarbonate represents a green and largely underexplored oxidizer generated electrochemically from aqueous carbonate solutions. Through state‐of‐the‐art electrolyzer technology, highly concentrated solutions have now become accessible. These were successfully employed as green oxidizer in deborolative hydroxylations. A plethora of phenols and alcohols have thus been synthesized in up to 99 % from organoboron compounds using only green and non‐toxic solvents. This transformation was successfully scaled‐up to multi‐gram batch sizes.