bluuebunny/crossref_metadata_2025_split huggingface dataset:
ULTRASONIC ASSISTED SYNTHESIS AND CHARACTERIZATION OF CHITOSAN GRAF WITH 2-(DIMETHYLAMINOETHYLMETHACRYLATE) (DMAEMA) Cs-g-PDMAEMA
Authors: Dalhatu Sani Nazifi , Modu Kolo Alhaji , Mahmoud Auwal Adamu , Adamu Harami M. , Murtala Ridwanu 
Published: January 2023

Purpose: Many researchers reported the use of chitosan in various applications due to its desirable properties, but then its application in a certain condition is limited due to its lower mechanical stability, lower solubility in certain solvents, and crystallinity of the polymer. Numerous report has been published by many researchers across the world modifying chitosan to enhanced its properties thereby improving its application in various field
Methodology: Poly (2-dimethylaminoethyl methacrylate) (Cs-g-PDMAEMA) were successfully synthesized by Ultrasonic methods for the first time. The synthetic method was optimized by varying various reaction parameters and reaction conditions. The grafting was confirmed by characterizing the copolymer with FTIR, XRD, XPS, SEM, TGA, DTG, and DTA.
Findings: The results show a good percent grafting and percent yield up to 132%G and 94.7%Y at optimum condition, and also shows a decrease of thermal stability and crystallinity of chitosan, there was improved in porosity of the surface, and complexity of the surface functional group making it a good candidate for metal chelating. Observing various changes in the spectrum of these derivatives and that of pure chitosan in addition to the change in properties of these polymers such as surface morphology, thermal stability, and crystallinity.
Uniqe Contribution to Theory, Practice and Policy: It was suggested that this modification may improve the application of these polymers.
KeyWords: Chitosan, Cs-g-PDMAEMA, Ultrasonication, Grafting
Implementasi Sistem Pemasaran Kenderaan Roda Empat Pada Showroom Pt Armada Banda Jaya
Authors: Zulkarnaini Iskandar , Andika Dedy 
Published: January 2023

Sistem pemasaran yang selama ini digunakan oleh PT. Armada Banda Jaya adalah menggunakan cara kerja sama dengan agen lapangan untuk memasarkan mobil. Sistem penjualan dengan cara ini membutuhkan waktu yang lama dalam proses penjualan mobil tersebut maka sistem ini di nilai kurang efektif dan efesien. Jika hanya mengandalkan sistem penjualan dengan cara tersebut maka pendapatan perusahaan tidak mengalami peningkatan yang signifikan. Selain itu perkembangan perusahaan terasa dinilai agak lambat. Dalam melakukan penjualan masih menggunakan cara manual. Oleh karena itu, diperlukan suatu sistem absensi mahasiswa yang dapat melakukan pendataan dan pengelolaan data agar dapat dilakukan secara cepat, efisien, dan akurat. Pembuatan sistem ini dilakukan dengan cara pengumpulan data, analisa sistem, perancangan sistem, dan implementasi sistem. Sistem ini dibuat dengan menggunakan bahasa pemrograman PHP dan MySQL untuk pengelolaan database. Sebagai hasil dari Skripsi ini adalah dibuatnya aplikasi berbasis web Sistem Informasi promosi Berbasis PHP Menggunakan web yang memiliki fasilitas seperti: manajemen data mobil, manajemen data penjualan, dan laporan rekap penjualan. Dengan adanya aplikasi ini, diharapkan proses promosi pemasaran mobil lebih efektif dan akurat
La violencia familiar y la gestión de su tratamiento terapéutico en el Ministerio de la Mujer y Poblaciones Vulnerables
Authors: Reyes Castillo Eduardo Antonio 
Published: January 2023

El presente trabajo aborda la relación de la violencia familiar y la gestión de los del tratamiento terapéutico en el Ministerio de la Mujer y poblaciones vulnerables, a través de metodologías sistemáticas, analíticas sintético e histórico se abordaran experiencias y buenas prácticas donde se realizara un enfoque a la relación que se da a través de políticas públicas inclusivas, de participación, de integralidad y la interseccionalidad, en la búsqueda de promover una adecuada gestión e implementación del tratamiento terapéutico en los casos de violencia familiar a fin de contribuir eficazmente en el empoderamiento y el tratamiento de la violencia contra las mujeres y los miembros del grupo familiar.
Передумови розвитку малого підприємництва в сільській місцевості
Authors: Maslak Oleksandr , Maslak Nataliia , Huzhvenko Serhii 
Published: January 2023

Мета. Мета статті – проаналізувати передумови для створення фермерських господарств сімейного типу на основі особистих селянських господарств, розглянути можливі сценарії розвитку таких процесів в Україні, визначити стратегічні цілі розвитку малого підприємництва в сільській місцевості та основні шляхи їхнього досягнення.
Методологія / методика / підхід. Теоретико-методичною основою дослідження є діалектичний метод пізнання економічних процесів, фундаментальні положення сучасної економічної теорії, законодавчі акти України, наукові праці вітчизняних і зарубіжних учених щодо тенденцій і специфіки розвитку малого підприємництва в сільській місцевості. Для досягнення поставленої мети використано методи логічного узагальнення та систематизації; абстрактний метод; прийоми аналогії та зіставлення.
Результати. Результати аналізу передумов для створення фермерських господарств сімейного типу на основі особистих селянських господарств свідчать про значний нереалізований потенціал в Україні. Реалізації цього процесу сприятиме наявність трудових, природних ресурсів і сприятливих агрокліматичних умов, а також зростання попиту на традиційні та органічні продукти харчування. Розглянуто сценарії можливого розвитку малого підприємництва в сільській місцевості та визначено більш прийнятним той, що передбачає за рахунок підтримки суб’єктів малого підприємництва та розбудови ринкової інфраструктури розширення асортименту сільськогосподарської продукції та продовольства, збільшення обсягів їхнього виробництва, підвищення якості. Визначено стратегічні цілі розвитку малого підприємництва в сільській місцевості та основні шляхи їх досягнення.
Оригінальність / наукова новизна. Уперше проведено SWOT-аналіз розвитку малого підприємництва в сільській місцевості України й розглянуто три альтернативні сценарії можливого розвитку такого підприємництва на селі. Основними шляхами для досягнення визначених стратегічних цілей передбачається створення сприятливого податкового, фінансового мікроклімату для діяльності малих форм підприємництва в сільській місцевості й розбудови інфраструктури аграрного ринку.
Практична цінність / значущість. Надано рекомендації для підготовки регіональних програм розвитку агропромислового виробництва та сільських територій. Серед стратегічних цілей регіональних програм розвитку агропромислового комплексу та сільських територій запропоновано передбачити розширення підприємницького середовища на селі та розвиток діяльності сільськогосподарських обслуговуючих кооперативів.
Cabozantinib (Cabometyx)
Authors: CADTH  
Published: January 2023

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses cabozantinib (Cabometyx), tablets, 20 mg, 40 mg, 60 mg oral.
Indication: For the treatment of adult patients with locally advanced or metastatic differentiated thyroid carcinoma (DTC) that has progressed following prior VEGFR-targeted therapy and who are radioactive iodine-refractory or ineligible.
Headache, Anxiety And Depression In Patients With Vaginismus
Authors: KENAR Safiye Gül , KARACA Müjdegül , ÖZAKŞİT Gülnur , YÜKSEL Hatice , BEKTAŞ Hesna 
Published: January 2023

Abstract
Objective: Vaginismus is one of the most common problems among patients who apply to the sexual health outpatient clinic. It is known that sexual problems are more common in migraine and tension-type headache patients. Furthermore, the frequency of depression and anxiety is higher in both vaginismus and chronic headache patients. This study was conducted in 2021 and examined the headache characteristics, depression and anxiety in vaginismus patients.
Material and methods: In this prospective study, 87 patients diagnosed with vaginismus in the sexual health outpatient clinic were interviewed. Fifty patients who agreed to participate in the study were questioned regarding headache, and Beck depression and Beck anxiety scales were applied.
Results: Headache was present in 46% (n:23) of 50 vaginismus patients. Anxiety scores of patients with headaches were higher than those without headaches (p=0.032). The most common type of headache was migraine without aura (60.9%), followed by tension-type headache (30.4%). Beck depression scores of the low-income group were higher than the high-income group (p=0.006). There was no significant correlation between monthly headache frequency, total headache duration, Beck depression score, and Beck anxiety score.
Conclusions: Headache is a common neurological symptom in vaginismus patients, and the frequency of migraine is higher than tension-type headaches. Anxiety values are higher in vaginismus patients experiencing a headache. Therefore, headache and anxiety should be considered in the follow-up and treatment of vaginismus patients.
Comparison Of Biochemical Markers and Insulin Resistance of Polycystic Ovary Syndrome Patients Diagnosed with the Criteria of Rotterdam, Androgen Excess Society and National Institutes of Health
Authors: KIRICI Pınar , ECİN Seval Müzeyyen , MAVRAL Nihal , ÇİÇEK Sevil , CELİK Ebru 
Published: January 2023

Objective: There are different criteria to diagnose polycystic ovary syndrome (PCOS) such as Rotterdam Consensus, Androgen Excess Society (AES), and National Institutes of Health (NIH). We aimed to investigate the biochemical and insulin resistance-related markers of PCOS patients according to different diagnostic criteria.
Material and methods: 1299 patients admitted to our clinic retrospectively analyzed. Following the inclusion and exclusion criteria, 200 patients with Rotterdam (Group 1), 182 patients with AES (Group 2), and 180 patients with NIH (Group 3) criteria were included in the study. Results: Waist/hip ratio among all groups (p1 = 0.002; p2 = 0.0001; p3 = 0.0001), LH/FSH ratio between Group 1 and 3 (p2=0.017), AST between Group 2 and 3 (p3 =0.012), DHEA-S and modified Ferriman–Gallwey score between Group 1 and 2 (p1 = 0.041; p1 = 0.013, respectively) and Group 1 and 3 (p2= 0.003; p2 = 0.04, respectively) were significantly different. A significant difference was detected between Group 1 and 3 in body mass index ≥ 25 (kg/m2) (p = 0.006). A significant difference was detected among all groups in waist circumference ≥ 88 cm (p1 = 0.0001, p2 = 0.0012, p3 = 0.004).
Conclusion: The rate of metabolic syndrome was found to be higher in patients diagnosed with Rotterdam criteria, the rate of insulin resistance with NIH criteria, and the rate of dyslipidemia with AES criteria. However, these differences were not statistically significant.
ANALISIS DAN PERANCANGAN SISTEM INFORMASI PENGAMBILAN SURAT CUTI KERJA BERBASIS WEB PADA UNIT PENGELOLA KEGIATAN (UPK) SADU MANDIRI KECAMATAN SADU
Authors: Yaakub Saleh , Madhrozji Tutuk , Ediansa Oka 
Published: January 2023

Design a Web -Based Information System hearts to present information about and permit in the industrial management with PHP and MySQL. The system will design, process and manage absence and permit in the corporation. Design Information System uses flow diagram modeling, and relationship diagram. Implementation from this Information System will make easy to have a Permit Decision and make be more effective and efficient process. This System will be based HTML 5, so can be accessed using a browser from all device
A Flexible, Sloppy Blob?
Authors: Ross Don 
Published: January 2023

AbstractLadyman and Ross argue that analytic metaphysics is a misguided enterprise that should give way to a naturalized metaphysics that aims to reconcile everyday and special-scientific ontologies with fundamental physics as the authoritative source of knowledge on the general structure of the universe. Le Bihan and Barton (argue, as against this, that analytic metaphysics remains useful as a basis for the body of work in AI known as “applied ontology.” They stop short of claiming, however, that analytic metaphysics is useful as metaphysics. I consider a basis for making the stronger claim: Smith's project for building what he claims to be metaphysical foundations for applied ontology (and for AI generally). Ultimately, the stronger claim is rejected; but in the course of this dialectic new aspects of the naturalistic metaphysical project come to light, including relationships between it and the traditional metaphysical project of providing foundations for philosophical semantics of truth and reference.
Pengembangan Sistem Informasi Kehadiran Siswa Berbasis Website
Authors: Panji Florensius 
Published: January 2023

Abstrak
Penelitian ini menggunakan metodologi Research And Development (R&D). Langkah-langkah untuk mengembangkan sistem informasi kehadiran siswa berbasis website menggunakan model ADDIE yang merupakan singkatan dari Analysis, Design, Development, Implementation, Evaluation. Penelitian ini bertujuan untuk (1)Untuk mengetahui pengembangan sistem informasi Kehadiran siswa berbasis website di SMP Harapan Ananda Pontianak.(2) Untuk mengetahui kelayakan dari sistem informasi Kehadiran siswa berbasis website di SMP Harapan Ananda Pontianak. (3)Untuk mengetahui bagaimana respon dari guru setelah di implementasikan sistem informasi Kehadiran siswa berbasis website. Kelayakan sistem diperoleh dari hasil validasi kepada dua ahli sistem, hasil yang diperoleh dari ahli sistem adalah 4,55 dengan kategori “sangat layak” untuk hasil uji coba respon guru berjumlah 9 guru diperoleh hasil 4.39 dengan kategori “sangat layak”. Dengan ini dapat disimpulkan bahwa sistem informasi kehadiran siswa berbasis website sangat layak digunakan.
Abstract
This research uses Research And Development (R&D) methodology. Steps to develop a website-based student attendance information system using the ADDIE model which stands for Analysis, Design, Development, Implementation, Evaluation. This study aims to (1) To find out the development of a website-based student attendance information system at SMP Harapan Ananda Pontianak. (2) To determine the feasibility of a website-based student attendance information system at SMP Harapan Ananda Pontianak. (3) To find out how the response from the teacher after implementing a website-based student attendance information system. The feasibility of the system was obtained from the validation results to two system experts, the results obtained from the system experts were 4.55 with the category of "very feasible" for the results of the teacher response trial totaling 9 teachers obtained results of 4.39 with the category "very feasible". With this it can be concluded that the student attendance information system is website-based.
Association of Lipid-Lowering Drugs With Risk of Psoriasis
Authors: Zhao Sizheng Steven , Yiu Zenas Z. N. , Barton Anne , Bowes John 
Published: January 2023

ImportanceLipid pathways have been implicated in the pathogenesis of psoriasis, and some lipid-lowering drugs, such as statins, are hypothesized to have disease-modifying properties. However, large population-level studies are scarce, and causal interpretation of results from traditional observational designs is limited by confounding.ObjectiveTo investigate the causal association between genetically proxied lipid-lowering drugs and psoriasis risk.Design, Setting, and ParticipantsThis 2-sample mendelian randomization study was performed from August to October 2022 and included population-level genome-wide association studies of psoriasis in the UK Biobank and FinnGen studies and low-density lipoprotein (LDL) by the Global Lipids Genetics Consortium. The inverse variance–weighted method was used with pleiotropy robust methods and colocalization as sensitivity analyses.ExposuresGenetically proxied inhibition of 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR, targeted by statins), Niemann-Pick C1–like 1 (NPC1L1, targeted by ezetimibe), and proprotein convertase subtilisin/kexin type 9 (PCSK9, targeted by, eg, alirocumab), using LDL as the biomarker.Main Outcomes and MeasuresRisk of psoriasis.ResultsData from 12 116 patients with psoriasis and approximately 1.3 million individuals with LDL measurement were analyzed. Genetically proxied PCSK9 inhibition was associated with reduced risk of psoriasis (odds ratio, 0.69 per standard deviation reduction in LDL; 95% CI, 0.55-0.88; P = .003), which was replicated in FinnGen (odds ratio, 0.71; 95% CI, 0.57-0.88; P = .002). Sensitivity analyses did not provide statistical evidence of bias from pleiotropy or genetic confounding. No robust association was found for HMGCR or NPC1L1 inhibition.Conclusions and RelevanceThis mendelian randomization study suggests that PCSK9 is implicated in psoriasis pathogenesis, and its inhibition is associated with reduced psoriasis risk. These findings potentially pave the way for future studies that may allow personalized selection of lipid-lowering drugs for those at risk of psoriasis.
Variation in Use of Lung Cancer Targeted Therapies Across State Medicaid Programs, 2020-2021
Authors: Roberts Thomas J. , Kesselheim Aaron S. , Avorn Jerry 
Published: January 2023

ImportanceTargeted therapies for EGFR (OMIM 131550)– and ALK (OMIM 105590)–altered metastatic non–small cell lung cancer (NSCLC) substantially improve outcomes for some patients. However, use of these therapies is lower among Medicaid patients, and access to oncology care varies across state Medicaid programs. Evidence is lacking on how use of targeted therapies for metastatic NSCLC varies across state Medicaid programs.ObjectivesTo characterize state-level variation in the use of targeted therapies among Medicaid patients with metastatic NSCLC and to describe factors associated with this variation.Design, Setting, and ParticipantsThis cross-sectional study used publicly available data from the Medicaid Drug Utilization Database from 2020 and 2021 and peer-reviewed data on NSCLC incidence, the prevalence of EGFR and ALK alterations, and expected treatment durations to estimate expected use of targeted therapies for EGFR- and ALK-altered NSCLC in 33 states.ExposuresState-specific Medicaid programs and state policies and characteristics.Main Outcomes and MeasuresThe primary outcome was the estimated proportion of person-time of Medicaid patients with EGFR- or ALK-altered NSCLC associated with receipt of targeted therapy in each state Medicaid program. Nested linear regression models examined associations between the observed variation and state policies and characteristics.ResultsThere were an estimated 3461 person-years in which EGFR- and ALK-targeted therapies were indicated in 2020 and 2021. During these years, only 2281 person-years of EGFR- and ALK-targeted therapies were dispensed to Medicaid patients, suggesting that an estimated 66% of Medicaid patients with EGFR- and ALK-altered metastatic disease received indicated targeted therapies across all states. Rates of targeted therapy use ranged from 18% in Arkansas to 113% in Massachusetts; 30 of 33 states (91%) had lower rates of targeted therapy use than expected. The observed variation across state Medicaid programs was associated with Medicaid policies, the density of oncologists, and state gross domestic product per capita.Conclusions and RelevanceThis study suggests that rates of targeted therapy use among Medicaid patients with EGFR- and ALK-altered NSCLC were lower than expected and varied across state Medicaid programs. State policies and characteristics were associated with the observed variation, indicating where interventions could improve access to treatment and outcomes for patients with NSCLC.
Relationship between objective cognitive functioning and work performance among Japanese workers
Authors: Shibaoka Michi , Masuda Masashi , Iwasawa Satoko , Ikezawa Satoru , Eguchi Hisashi , Nakagome Kazuyuki 
Published: January 2023

Abstract

Objectives
We aimed to explore the relationship between objective cognitive functioning and work performance among Japanese workers.

Methods
From February to November 2019, this cross-sectional study enrolled workers aged 18–65 years from 10 companies located in a metropolitan area of Japan. We emailed invitations to participate to employees of companies that had agreed to cooperate with the study. We measured work performance with the question, “How would you rate your performance (compared with your optimum performance) over the past 4 weeks?” Responses were made via a visual analog scale (range: 0–100). Cognitive functioning was assessed using the THINC-integrated tool (THINC-it®). THINC-it® is a brief, objective computerized cognitive assessment battery. Associations between work performance and cognitive functioning tests were examined using logistic regression analysis.

Results
In total, 353 individuals provided e-consent to participate, of whom 276 were included in the analysis (after omitting those with missing values). The median work performance was used to divide participants into high- (scoring ≥ 80%) and low- (scoring &lt; 80%) performing groups. The P-values for trends indicated that association between cognitive domains, such as attention, executive functioning and working memory was significant (P &lt; .05). Work performance was significantly associated with cognitive function for the two tests that assess attention, executive functioning, and working memory in general workers.

Conclusions
Our results suggest that objective cognitive functioning may be related to work performance. Longitudinal investigations may allow for the establishment of causality.
Ultra‐Histocompatible and Electrophysiological‐Adapted PEDOT‐Based Hydrogels Designed for Cardiac Repair
Authors: Yu Chaojie , Yue Zhiwei , Zhang Hong , Shi Mingyue , Yao Mengmeng , Yu Qingyu , Liu Min , Guo Bingyan , Zhang Haitao , Tian Leqi , Sun Hong , Yao Fanglian , Li Junjie 
Published: January 2023

AbstractCurrently, although conducting polymers have exhibited potential electrophysiological modulation, designing bioinspired ultra‐histocompatible conducting polymers remains a long‐standing challenge. Moreover, the water dispersibility, conductivity, and biocompatibility of conducting polymers are incompatible, which restricts their application in tissue engineering. Herein, a multilevel template dispersion strategy is presented to produce poly(3,4‐ethylenedioxythiophene):(dextran sulfate/carboxymethyl chitosan) (PEDOT:(DSS/CMCS)) with biocompatibility superior to that of commercial poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) without sacrificing processability and conductivity. The PEDOT:(DSS/CMCS) and oxidized dextran solutions form an injectable PEDOT‐based hydrogel (PDCOH) mediated by dynamic covalent imine bonds under mild conditions. The PDCOH has a tissue‐matched modulus and conductivity to adapt to the mechanical environment of dynamic tissue and modulate fibrosis‐induced electrical decoupling. The PDCOH combined with adipose‐derived stem cells demonstrates superior cardiac repair effects over cell suspensions and nonconductive hydrogels, inhibiting ventricular remodeling, reducing fibrous scarring, promoting vascular regeneration, and restoring electrophysiological and pulsatile functions.