bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the economics and environmental friendliness of Area-compensated GSHPs in cold regions in China
Authors: wang pengxuan , Wang Yixi , Gao Weijun , Xu Tongyu , Wei Xindong , Shi Chunyan , Qi Zishu , Bai Li 
Published: June 2023

Abstract
Ground Source Heat Pump is widely used in heating and cooling as a clean and efficient energy utilization technology. In cold regions, ground source heat pump systems have significant economic and environmental benefits. In this paper, we analyze the economic and environmental benefits of Area-compensated ground source heat pump systems in cold regions that achieve cooling and heating load balance through area compensation technology to assess their potential for sustainable development and environmental protection. The results show that the Area-compensated ground source heat pump system can operate stably and efficiently over a long period of time, and although the initial investment in the system is high, the initial investment can be recovered in a relatively short period of time by reducing energy consumption and operating costs. Compared with traditional heating and air conditioning systems, ground source heat pump systems can significantly save energy consumption and operating costs. At the same time, with the long-term operation of Area-compensated ground source heat pump systems, carbon dioxide emissions and air pollution can be greatly reduced compared to conventional systems. Area-compensated ground source heat pump systems provide a new way for sustainable development and environmental protection in cold regions by reducing energy consumption and operating costs, greenhouse gas emissions and pollutant release, and support the promotion of ground source heat pump systems in practical applications.
Long-term plasma-activated-water irrigation improves fruit yield in tomato
Authors: Priatama Ryza A. , Beak Hong Kwan , Song Ilchan , Park Soon-ju , Lee Young Koung 
Published: June 2023

Abstract
Plasma agriculture has recently gained popularity owing to its potential applications in precultivation, cultivation, and postharvest processes. Plasma treatments are beneficial seed-priming agents for improving seed germination. The increase plant growth during the seedling stage and enhance fruit storage duration during postharvest treatment. However, little research has been conducted to confirm the long-term effects of plasma-activated water (PAW) treatment on plant cultivation during stages from germination to harvest. Here, we demonstrate the utilization of PAW, generated from a single dielectric barrier discharge (SDBD) device, to understand the functional role of PAW in the cultivation of tomato ‘Micro-Tom’, from germination to harvest. PAW treatment enhanced the growth of young seedlings and increased the number of flowers, plant biomass, and yield compared with the control. Moreover, no adverse effects on the characteristics of fruits produced by PAW-treated plants were observed. These results highlight the potential of PAW as an alternative ecofriendly nutrient source for plant irrigation under nutrient-limiting conditions, during all the stages from seeds to fruits, and offer promising implications for future agricultural practices.
Long-term follow-up after the treatment of obstructive cuspids in the maxilla causing severe root resorption of the lateral incisors: two case reports
Authors: LI Ning , YANG Liu , YANG Qian , WANG Hongning , XU Xiaolin , WANG Tiejun 
Published: June 2023

Abstract
Background
Root resorption of adjacent teeth due to obstructed canines is common, and orthodontic treatment often leads to secondary resorption or even loss of adjacent roots. Clinical reports of long-term stability after treatment are rare.
Case presentation:
This study reports two cases of maxillary cuspid obstruction resulting in severe root resorption of the adjacent lateral incisors. Surgical exposure, orthodontic retraction and alignment of the impacted cuspids successfully retracted the impacted cuspids in both cases, and the resorbed lateral incisors were stable with no significant loosening and normal pulp vitality after treatment and 5 and 10 year follow-up.
Conclusions
Light orthodontic force may be used to move teeth with root resorption of adjacent teeth due to obstructive teeth. The path and direction in which the teeth are moved must be specifically designed so that the adjacent roots are not resorbed and long-term stability can be achieved.
Prevalence and impact of atrial fibrillation in elderly patients with hypertrophic cardiomyopathy
Authors: Song Changpeng , Cui Jingang , Zheng Xinxin , Lu Jie , Guo Xinli , Wang Shuiyun , Huang Xiaohong 
Published: June 2023

Abstract
Background: The study sought to identify the prevalence and the influence of atrial fibrillation (AF) on clinical course and outcomes in elderly patients with hypertrophic cardiomyopathy (HCM).
Methods: From January 2014 to December 2017, 351 consecutive elderly patients diagnosed with HCM in our center were enrolled in this study. Clinical and echocardiographic variables were assessed in association with AF. The effect of AF on all-cause and cardiovascular mortality was evaluated with multivariate Cox proportional hazards models.
Results: Of 351 patients (53% males, mean age 70.6 ± 5.2 years) with HCM, 122 (35%) had AF. AF was related to New York Heart Association (NYHA) class III/IV (OR=2.14, 95%CI: 1.27-3.63, P=0.005), history of stroke (OR=2.39, 95%CI: 1.16-4.91, P=0.018), left atrial dimension (OR=1.13, 95%CI: 1.08-1.19, P<0.001) and pulmonary hypertension (OR=2.91, 95%CI: 1.19-7.10, P=0.019). Over a median of follow-up period of 67 ± 22 months, 72 patients (21%) died. The five-year survival free from all-cause mortality was 83%, 70%, and 89% in the overall HCM population, AF, and non-AF groups, respectively. AF was a significantly independent predictor of all-cause mortality (HR=1.80, 95% CI: 1.02-3.86, P=0.042) and cardiovascular mortality (HR=1.89, 95% CI: 1.08-3.31, P=0.026). In addition, age and NYHA class III/IV were also independent predictors of all-cause and cardiovascular mortality.
Conclusion: AF was common and related to a variety of clinical variables in elderly patients with HCM. As AF was independently associated with poor outcomes, comprehensive managements of AF were important for those elderly patients with HCM and AF.
Comparison of cisplatin-based versus standard preoperative chemotherapy in patients with operable triple-negative breast cancer: Propensity score matching and inverse probability of treatment weighting analysis
Authors: Yamaguchi Ayane , Kawaguchi Kosuke , Kawanishi Kana , Maeshima Yurina , Nakakura Akiyoshi , Kataoka Tatsuki , Takahara Sachiko , Takada Masahiro , Kawashima Masahiro , Sakita-Kawaguchi Nobuko , Kotake Takeshi , Suzuki Eiji , Shimizu Hanako , Torii Masae , Morita Satoshi , ishiguro Hiroshi , Toi Masakazu 
Published: June 2023

Abstract
Purpose:
The efficacy of carboplatin is non-equivalent to that of cisplatin (CDDP) for various tumor types in curative settings. However, the role of CDDP in operable triple-negative breast cancer (TNBC) patients remains unknown. We conducted a multicenter observational study to examine the effects of CDDP added to preoperative chemotherapy in patients with TNBC.
Methods:
This retrospective study consecutively included previously untreated patients with stage I–III TNBC treated with preoperative chemotherapy with or without CDDP. The primary endpoint was distant disease-free survival (DDFS). Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were used to minimize confounding biases in comparisons between the two groups.
Results:
A total of 138 patients were enrolled in the study. Of these, 52 were in the CDDP group and 86 in the non-CDDP group. DDFS was significantly better in the CDDP group than in the non-CDDP group (unadjusted hazard ratio (HR) 0.127 and p < 0.001, PSM HR 0.141 and p < 0.003, IPTW HR 0.123 and p = < 0.001). Furthermore, among the patients with residual cancer burden (RCB) class II/III, DDFS was better in the CDDP group than in the non-CDDP group (unadjusted HR 0.192 and p = 0.013, PSM HR 0.237 and p = 0.051, IPTW HR 0.124 and p = 0.059).
Conclusions:
Our study showed that CDDP-containing regimens achieved favorable prognoses in patients with operable TNBC, especially for the RCB class II/III population. Confirmative studies are warranted to elucidate the role of CDDP in TNBC treatment.
Effect of Temperature Humidity Index (THI) on Resting Pattern of Dairy Cows in Different regions of Sri Lanka
Authors: weerasinghe Gayani , Rajapaksha Eranda , Samarakone Thusith 
Published: June 2023

Abstract
The ability to spend more time resting is extremely important for dairy cattle welfare. Through this study, lying behaviour of dairy cows belonged to Up-Country (UP), Mid-Country (MC), Coconut-Triangle (CT) and Western-Province (WP) of Sri Lanka was studied to get an insight into their resting pattern. Resting pattern was assessed in 170 Holstein-Friesian/Jersey crossed, tie-stalled lactating cows (UP = 49, MC = 49, CT = 48 and WP = 24) using electronic data loggers. Proper resting behaviours were attained in UP and MC regions with longer lying time (11.7, 11.3 h/d) and lying bout durations (78.0, 84.9 min) respectively where better THI ranges were observed compared to other regions. WP and CT resulted with lower lying times (9.00, 9.26 h/d) and lying bout durations (48.3, 64.3 min) respectively with higher THI ranges. Cows in all regions prefer to lie on their left side (UP-6.1, MC-6.1, CT-4.4, WP-4.7 h/d) and was significantly differ (P < 0.05) between MC-WP, MC-CT, UP-CT and UP-WP. A negative significant (P < 0.05) correlation was observed between THI and lying behaviour of cows. Unique pattern of diurnal lying down was detected with significant effect (P < 0.05) of time (hour) and Time x Treatment interaction. More lying down was observed in late night and early morning with a peak rest around the hours of 21:00–05:00. Overall, according to the results of the current study, the existing environmental conditions of four regions affected the resting pattern of dairy cows and, identification of possible mechanisms to modify cow’s environment to enhance cow comfort is vital.
Predictive value of combined diagnosis of albumin with alkaline phosphatase or monocyte percentage on the first day of admission to hospital for the risk of death from sepsis
Authors: Zhang Nannan , Tong Wenjing , Gui Yonghui , Yang Peng 
Published: June 2023

Abstract
Objectives: The objective of this study was to evaluate the predictive value of the combined diagnosis of albumin with alkaline phosphatase or monocyte percentage in the risk of death from sepsis.
Methods: A total of 185 patients admitted to the First Affiliated Hospital of Anhui Medical University from February 2022 to January 2023 were selected as the research objects.Laboratory data is selected at admission.To identify potential independent risk factors for sepsis, a multivariate logistic regression analysis was performed.Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive accuracy of ALP, MONO% combined with ALB or the combined diagnosis of all three for mortality outcome in patients with sepsis.
Results: Multiple logistic regression analysis showed that ALB, ALP, and MONO% were independent risk factors for death in patients with sepsis. As shown in Table 3, compared with the diagnosis of ALB alone. ALP or MONO% were diagnosed in combination with ALB or with all three, when all negative predictive values > 96%,the positive predictive value was increased from 36.36% to 42.11%, 46.88% and 47.05%; and the positive likelihood ratio was increased from 4.71 to 6.00 ,7.28 and 7.33 when in the case of negative likelihood ratio < 0.3 for all.
Conclusions: Our study demonstrates that the combined diagnosis of ALP or MONO% with ALB or the combined diagnosis of the three had higher diagnostic value than the single diagnosis of ALB. And the results of this study provide some laboratory basis for the combined laboratory multi-indicator diagnosis of patients with sepsis at risk of death.
Preoperative frailty predicts postoperative pain after total knee arthroplasty in elderly patients: a prospective observational study
Authors: Jin Yinan , Tang Suhong , Wang Wenwen , Zhang Wei , Hou Yunfan , Jiao Yang , Hou Bailing , Ma Zhengliang 
Published: June 2023

Abstract
Purpose
Frailty is a complex clinical syndrome characterized by reduced physiological reserves, which is reportedly associated with postoperative adverse outcomes and may increase the risk of postoperative pain. Our study aimed to explore whether frailty was an independent risk factor for pain after total knee arthroplasty (TKA) in elderly patients.
Methods
Included in this prospective observational study were patients aged 65 or older who underwent primary TKA. Frailty of the patients was assessed before surgery using the comprehensive geriatric assessment-frailty index and pain was evaluated before and after surgery using the Numerical Rating Scale.
Results
Of the 164 patients included in the final analysis, 51 patients were identified as being frail. Patients with chronic postsurgical pain (CPSP) had a significantly higher frailty index than those without CPSP, which was the same in patients with acute postoperative pain (APSP). After adjusting for other confounding factors, frailty was shown to be an independent risk factor for both CPSP (OR: 4.242, 95% CI: 1.286–13.997, P = 0.018) and APSP (OR: 13.232, 95% CI: 3.731–46.929, P < 0.001). The area under the receiver operating characteristic curve for frailty predicting CPSP was 0.728 (P < 0.001, 95% CI: 0.651–0.805).
Conclusions
Our findings demonstrated that preoperative frailty in elderly patients was a predictor of acute and chronic postoperative pain after TKA, suggesting that the frailty assessment should become a necessary procedure before operations, especially in elderly patients.
An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans
Authors: MacKenzie Alasdair , McEwan Andrew , Hing benjamin , Erickson Johanna , Urama Charity , Norton-Hughes Emily , Berry Susan , D'Ippolito Mariam , Delibegovic Mirela , Grassmann Felix 
Published: June 2023

Abstract
Obesity and anxiety are morbidities notable for their increased impact on society during the recent COVID-19 pandemic. Understanding the mechanisms governing susceptibility to these conditions will increase quality of life and our resilience to future pandemics. In the current study we explored the function of a highly conserved regulatory region (BE5.1) within the BDNF gene that harbours a polymorphism strongly associated with obesity (rs10767664; p = 4.69x10− 26). Analysis in primary cells suggested that the major T-allele of BE5.1 was an enhancer whereas the obesity associated A-allele was not. However, CRISPR/CAS9 deletion of BE5.1 from the mouse genome (BE5.1KO) produced no significant effect on the expression of BDNF transcripts in the hypothalamus, no change in weight gain after 28 days and only a marginally significant increase in food intake. Nevertheless, transcripts were significantly increased in the amygdala of female mice and elevated zero maze and marble burying tests demonstrated a significant increase in anxiety-like behaviour that could be reversed by diazepam. Consistent with these observations, human GWAS cohort analysis demonstrated a significant association between rs10767664 and anxiousness in human populations. Intriguingly, interrogation of the human GTEx eQTL database demonstrated no effect on BDNF mRNA levels associated with rs10767664 but a highly significant effect on BDNF-antisense (BDNF-AS) gene expression and splicing. The subsequent observation that deletion of BE5.1 also significantly reduced BDNF-AS expression in mice suggests a novel mechanism in the regulation of BDNF expression common to mice and humans which contributes to the modulation of mood and anxiety in both species.
Estimated Cardiorespiratory Fitness and Incident Risk of Cardiovascular Disease in China
Authors: Liu Yuanjiao , Zhu Jinghan , Guo Ziye , Yu Jiazhou , Zhang Xuhui , Ge Huiqing , Zhu Yimin 
Published: June 2023

Abstract
Background
Limited evidence is available on the association between estimated cardiorespiratory fitness (e-CRF) and incidence of cardiovascular disease (CVD) in Chinese population.
Methods
A total of 10507 participants from the China Health and Retirement Longitudinal Study (CHARLS) was recruited as baseline. e-CRF was calculated from sex-specific longitudinal non-exercise equations and further grouped into quartiles. Cox proportional models were used to calculate hazard ratio (HR) and 95% confidence interval (CI) for incidence risks of CVD, heart disease and stroke.
Results
During a median follow-up of 7 years, a total of 1862 CVD, 1409 heart disease and 612 stroke events occurred. In fully adjusted models, each one MET increment of e-CRF was associated with lower risk of CVD (HR = 0.91, 95%CI = 0.85–0.96 for males, HR = 0.87, 95%CI = 0.81–0.94 for females). Compared with the Quartile (Q)1 group, the HRs (95%CI) of the Q2, Q3 and Q4 groups were 0.84 (0.63–1.03), 0.72 (0.57–0.91) and 0.66 (0.51–0.87) for CVD in males. Females had HRs of 0.79 (0.66–0.96) in Q2, 0.71 (0.57–0.88) in Q3 and 0.58 (0.45–0.75) in Q4 for CVD. The associations between e-CRF and heart disease and stroke were slightly weaker than that for CVD in both males and females.
Conclusions
Higher e-CRF decreases the incident risk of CVD, heart disease and stroke.
Operational Analysis of the Pediatric Patient Flow in a Hospital
Authors: Takagi Hideaki , Kanai Yuta 
Published: June 2023

Abstract
The authors of this paper have been studying the system-scientific modeling of the inpatient flow in an acute-care hospitalusing the recorded order log data for the movement of patients over the observation period. We have thus far published theresults for obstetric \cite{Takagi-Kanai-Misue} and neonatal \cite{Kanai-Takagi} patients.The order log in the University of Tsukuba Hospital during the two fiscal years 2010--2011 is used as a data source.
In the present study, we deal with pediatric patients who are transferred over several wards from their admission untiltheir discharge. We calculate the number of admissions, ward transfers, and discharges during the two years of observation.Special attention is paid to the numbers of patients who are hospitalized before and after the finite observation periods.We consider the total number of days on which patients stay in each ward over the observation period, which is called the\textit {patient-days} (PD) as a measure of clinical load brought by patients on the hospital. We count the numbers ofpatients who arrive to, depart from, and stay in each ward over the observation period and show that these numberssatisfy the \textit{conservation law} for the patient flow in a hospital. We also confirm an identity relation among the meannumber of patients staying in each ward per day, mean number of patients who arrive to that ward per day, and mean numberof days a patient stays in that ward, called the mean \textit{length-of-stay} (LoS), which may be thought of as adiscrete-time, finite-horizon version of \textit{Little's law} in queueing theory. We propose a \textit{patient residence chart}to visualize the movement of each patient during their hospitalization. We present a method to classify the paths of patients,i.e., a sequence of pairs (ward number, length-of-stay on that ward), from which we calculate a variety of measures ofpatient movement.
Super-speed high-resolution distributed Brillouin sensor for mapping strain waves propagating an optical fiber
Authors: Song Kwang-Yong , Kim Ju Hyun , Yoon Jae Hyeong 
Published: June 2023

Abstract
Distributed fiber sensors based on Brillouin scattering have recently advanced into high-speed and high-resolution systems, aimed at identifying and characterizing dynamic strain events in civil structures and materials. This article introduces a super-speed, high-resolution distributed Brillouin sensor implemented through the utilization of lock-in-free balanced detection of orthogonally-polarized probe sidebands. The proposed system achieves a sampling rate exceeding 106 Sa/s (1 MSa/s) with a centimeter-level spatial resolution, surpassing the capabilities of previous Brillouin sensors. In test experiments, we demonstrate the polarization-independent measurement of the local Brillouin gain spectrum at a sampling rate of 2 MSa/s with a spatial resolution of 5 cm. Additionally, we acquire the full distribution map of Brillouin frequency along a 5.2 m standard single-mode fiber, utilizing a 10 kHz repetition rate and 144 sampling points. This high-performance system allows us to analyze the occurrence and propagation of the axial strain waves in a suspended optical fiber, induced by the popping noise of a powered speaker.
A detailed study to understand controlled additive manufacturing of regenerated cellulose
Authors: Garces Irina , Ngo Tri-Dung , Ayranci Cagri , Boluk Yaman 
Published: June 2023

Abstract
Environmental concerns within the 3D printing industry have attracted interest in finding biodegradable, eco-friendly material solutions. Cellulose is the most abundant natural polymer on the planet. Cellulosic pulp, derived from biomass, can be dissolved in eco-friendly solvents such as N-methyl morpholine N-oxide (NMMO) to produce Lyocell™. Lyocell™ has had applications in the textile industry for the last decade. It has shown promise in producing high-quality cellulosic fibers and the ability to be altered, tailored, and manufactured with ease. Despite this, additive manufacturing using cellulose is still an area of research with ample room to grow. In this work, we propose an in-depth study of using Lyocell™ to manufacture 3D-printed parts using an affordable desktop 3D-printer modification. The 3D printing process of Lyocell™ is completely circular as the solvent can be recovered from 3D-printed parts, and the printed parts are biodegradable. The design of the developed 3D printing equipment, the rheological properties, and the 3D printing of the cellulose-NMMO solution are discussed in this work.