bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Immunocompetence and Biomarkers of Tolerance in Chimeric and Immunosuppression-free Kidney Allograft Recipients
Authors: Leventhal Joseph R. , Galvin John , Ison Michael G. , Feng Chris Yuhsuen , Ding Ruchuang , Lee John R. , Li Carol , Mathew James M. , Gallon Lorenzo , Gibson Meg , Belshe Dianne , Tollerud David J. , Gornstein Eric , Suthanthiran Manikkam , Ildstad Suzanne T. 
Published: June 2023

Background.
Thirty-seven patients have received a living-donor kidney transplant in a phase 2 study designed to induce tolerance with facilitated allogeneic hematopoietic stem cell transplant. The study protocol is based on tolerogenic CD8+/T-cell receptor− facilitating cells (FCR001; also including hematopoietic stem cells and αβ-T-cell receptor+ T cells) and low-dose, nonmyeloablative conditioning. Persistent chimerism allowing full immunosuppression (IS) withdrawal was achieved in 26 patients (time off IS 36–123 mo).

Methods.
We evaluated biomarkers of tolerance through urinary cell mRNA profiling and immunocompetence to respond to vaccination in these patients. We also assessed kidney function and metabolic parameters compared with standard-of-care patients on IS.

Results.
Persistently chimeric patients retained chimerism after removal of IS and remained rejection free without donor HLA–specific antibody development. The presence of donor chimerism at >50% correlated with a signature of tolerance in urinary cell mRNA profiles, with a uniquely elevated increase in the ratio of cytotoxic T lymphocyte–associated protein 4 to granzyme B mRNA. Tolerance was associated with protection from recurrence of immune-mediated causes of kidney disease. Tolerant participants were safely vaccinated, developed protective immune responses, and did not lose chimerism after vaccination. When compared with kidney transplant recipients treated with standard IS, tolerant participants showed stable kidney function and reduced medication use for hypertension and hyperlipidemia.

Conclusions.
These results suggest that elimination of IS has distinct advantages in living-donor kidney allograft recipients.
Reemergence of Acute ischemic Stroke hospitalizations in the United States from 2010 to 2020
Authors: Elbayomy Ahmed M. , Kim Jason J , Ammanuel Simon G , Bradbury Edward L. , Dempsey Robert J , Ahmed Azam S. 
Published: June 2023

AbstractBackground and ObjectivesStroke hospitalization rates in the United States are unequally distributed across the population. Factors such as age, race, socioeconomic status, and sex are associated with different hospitalization rates for acute ischemic stroke (AIS). This study aimed to review the patterns in these rates from 2010 to 2020.MethodsThe National Inpatient Sample (NIS) was used to analyze patterns in AIS hospitalizations in the United States between 2010 and 2020. The hospitalization rates were examined based on age, sex, race, region, stroke comorbidities, and income.ResultsThe overall rate of AIS hospitalization increased from 230 to 254 per 100,000 individuals (+10.4%) between 2010 and 2020. Initially, the rates declined from 2010 to 2015 (230 to 227 per 100,000); however, from 2016 to 2020, the AIS hospitalization rates (AIS-HR) increased (242 to 254 per 100,000). The rate of AIS hospitalization increased significantly for individuals aged 25–44 years (25–37 per 100,000, +48.0%) and 45–65 years (171–235 per 100,000, +37.4%). AIS hospitalization rates remained relatively stable for individuals aged 65– 84 years (669–688 per 100,000, +3.7%) and declined for those over 85 years (2005–1756 per 100,000, -12.4%). Among sex comparisons, AIS hospitalization rates were stable in women (241–250 per 100,000, +3.7%) and increased in men (270–308 per 100,000, +14.1%). In terms of race, Blacks had the highest age-adjusted yearly hospitalization rate (437), followed by Whites (215) and Hispanics (207) per 100,000 in 2020. There was a stepwise increase in AIS hospitalization rates based on the Charlson Comorbidity Index (CCI), with White, Black, and Hispanic populations having AIS hospitalization rates of CCI 0 and 1 (533, 434, and 233), CCI 2 (2197, 2555, and 2125), and CCI ≥ 3 (5283, 5724, and 4767) per 100,000, respectively.DiscussionAlthough the overall AIS hospitalization rate increased between 2010 and 2020, there was an initial decline until 2015, followed by a resurgence. This resurgence in AIS hospitalization rates was driven by greater underlying comorbidities, with disproportionate increases observed in Black and Hispanic populations. Further population analyses and cohort studies are required to confirm our findings.
Thermal compensation reduces DNA damage in UV-exposed amphibian larvae: Implications for high latitudinal and altitudinal species
Authors: Hird Coen , Cramp Rebecca L. , Franklin Craig E. 
Published: June 2023

ABSTRACT1. Increases in ultraviolet radiation (UVR) correlate spatially and temporally with global amphibian population declines and interact with other stressors such as disease and temperature. Declines have largely occurred in high-altitude areas associated with greater UVR and cooler temperatures.2. UVR is a powerful mutagenic harming organisms largely by damaging DNA. When acutely exposed to UVR at cool temperatures, amphibian larvae have increased levels of DNA damage. Amphibians may be able to compensate for the depressive effects of temperature on DNA damage through thermal acclimatisation, but it is unknown whether they or other ectotherms have this capacity.3. We reared striped marsh frog larvae (Limnodynastes peronii) in warm (25°C) and cool (15°C) temperatures under either a low or moderate daily dose of UVR (10 and 40 µW cm-2UV-B for 1 h at midday, respectively) for 18-20 days and then measured immediate DNA damage resulting from an acute high UVR dose (80 µW cm-2UV-B for 1.5 h) at a range of test temperatures (10, 15, 20, 25, and 30°C).4. Larvae acclimated to 15°C and exposed to UVR at 15°C completely compensated UVR-induced DNA damage compared with 25°C acclimated larvae exposed to UVR at 25°C. Additionally, warm-acclimated larvae had higher CPDs than cold-acclimated larvae across test temperatures, which indicated a cost of living in warmer temperatures. In contrast, larvae reared under chronic elevated UVR levels showed no evidence of UVR acclimation resulting in lower DNA damage following an acute high UVR exposure.5. Our finding that thermal acclimation inL. peroniilarvae compensated UVR-induced DNA damage at low temperatures suggested that aquatic ectotherms living in cool temperatures may be more resilient to high UVR than previously realised.6. We suggested individuals or species with less capacity for thermal acclimation of DNA repair mechanisms may be more at risk if exposed to changing thermal and UVR exposure regimes but cautioned that thermal acclimation of DNA repair mechanisms may not always be beneficial.
Estimating the population-level kidney benefits of improved uptake of SGLT2 inhibitors in patients with chronic kidney disease in Australian primary care
Authors: Neuen Brendon L , Jun Min , Wick James , Kotwal Sradha , Badve Sunil V , Jardine Meg J , Gallagher Martin , Chalmers John , Nallaiah Kellie , Perkovic Vlado , Peiris David , Rodgers Anthony , Woodward Mark , Ronksley Paul E 
Published: June 2023

AbstractBackgroundAlthough sodium glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of kidney failure and death in patients with chronic kidney disease (CKD), they are underused in routine clinical practice. We evaluated the number of patients with CKD in Australia that would be eligible for treatment with an SGLT2 inhibitor and estimated the number of cardiorenal and kidney failure events that could be averted with improved uptake of SGLT2 inhibitors.MethodsUsing nationally-representative Australian primary care data (MedicineInsight), we identified patients that would have met inclusion criteria of the CREDENCE, DAPA-CKD, and EMPA-KIDNEY trials between 1 January 2020 and 31 December 2021. We applied these data to age and sex-stratified estimates of CKD prevalence from the broader Australian population (using national census data) to generate population-level estimates for: (1) the number of CKD patients eligible for treatment with SGLT2 inhibitors and (2) the annual number of potentially preventable cardiorenal (CKD progression, kidney failure, or death due to cardiovascular disease or kidney failure), and kidney failure events with SGLT2 inhibitors based on trial event rates.ResultsIn MedicineInsight, 44.2% of adults with CKD would have met CKD eligibility criteria for an SGLT2 inhibitor; baseline use was 4.1%. Applying these data to the broader Australian population, we estimated 230,246 patients with CKD in Australia would have been eligible for treatment with any SGLT2 inhibitor. Optimal implementation of SGLT2 inhibitors (75% uptake in eligible patients) could reduce cardiorenal and kidney failure events annually in Australia by 3,644 (95% CI 3,526-3,764) and 1,312 (95% CI 1,242-1,385), respectively.ConclusionsImproved uptake of SGLT2 inhibitors for patients with CKD in Australian primary care has the potential to prevent large numbers of patients experiencing CKD progression or dying due to cardiovascular or kidney disease. Identifying strategies to increase the uptake of SGLT2 inhibitors is critical to realising the population-level benefits of this drug class.
Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems
Authors: Shakeshaft Amy , Martin Joanna , Dennison Charlotte A. , Riglin Lucy , Lewis Cathryn M. , O’Donovan Michael C. , Thapar Anita 
Published: June 2023

AbstractAnxiety and depression (emotional disorders) are familial and heritable, especially when onset is early. However, other cross-generational studies suggest transmission of youth emotional problems is explained by mainly environmental risks. We set out to test the contribution of parental non-transmitted genetic liability, as indexed by psychiatric/neurodevelopmental common polygenic liability, to youth emotional problems using a UK population-based cohort: the Millennium Cohort Study. European (N=6,328) and South Asian (N=814) ancestries were included, as well as a subset with genomic data from both parents (European: N=2,809; South Asian: N=254). We examined the association of transmitted (PGST) and non-transmitted polygenic scores (PGSNT) for anxiety, depression, bipolar disorder and neurodevelopmental disorders (attention-deficit/hyperactivity disorder [ADHD], autism spectrum disorder [ASD], schizophrenia) with youth emotional disorder and symptom scores, measured using the parent-and self-reported Strengths and Difficulties Questionnaire emotional subscale at 6 timepoints between ages 3-17 years. In the European sample, PGSTfor anxiety and depression, but not bipolar disorder, were associated with emotional disorder and symptom scores across all ages, except age 3, with strongest association in adolescence. ADHD and ASD PGSTalso showed association across ages 11-17 years. In the South Asian sample, evidence for associations between all PGSTand outcome measures were weaker. There was weak evidence of association between PGSNTfor anxiety and depression and age 17 symptom scores in the South Asian sample, but not in the European sample for any outcome. Overall, PGSTfor depression, anxiety, ADHD and ASD contributed to youth emotional problems, with stronger associations in adolescence. There was limited support for non-transmitted genetic effects: these findings do not support the hypothesis that parental polygenic psychiatric/neurodevelopmental liability confer risk to offspring emotional problems through non-transmitted rearing/nurture effects.
Pancreatic Tumor-Derived Extracellular Vesicles Stimulate Schwann Cell Phenotype Indicative of Perineural Invasion via IL-8 Signaling
Authors: Gregory Emory , Powers Isabel , Jamshidi-Parsian Azemat , Griffin Robert , Song Younghye 
Published: June 2023

AbstractPancreatic cancer remains a pre-eminent cause of cancer-related deaths with late-stage diagnoses leading to an 11% five-year survival rate. Moreover, perineural invasion (PNI), in which cancer cells migrate into adjacent nerves, occurs in an overwhelming majority of patients, further enhancing tumor metastasis. PNI has only recently been recognized as a key contributor to cancer progression; thus, there are insufficient treatment options for the disease. Attention has been focused on glial Schwann cells (SC) for their mediation of pancreatic PNI. Under stress, SCs dedifferentiate from their mature state to facilitate the repair of peripheral nerves; however, this signaling can also re-direct cancer cells to accelerate PNI. Limited research has explored the mechanism that causes this shift in SC phenotype in cancer. Tumor-derived extracellular vesicles (TEV) have been implicated in other avenues of cancer development, such as pre-metastatic niche formation in secondary locations, yet how TEVs contribute to PNI has not been fully explored. In this study, we highlight TEVs as initiators of SC activation into a PNI-associated phenotype. Proteomic and pathway assessments of TEVs revealed an elevation in interleukin-8 (IL-8) signaling and nuclear factor kappa B (NFκB) over healthy cell-derived EVs. TEV-treated SCs exhibited higher levels of activation markers, which were successfully neutralized with IL-8 inhibition. Additionally, TEVs increased NFκB subunit p65 nuclear translocation, which may lead to increased secretion of cytokines and proteases indicative of SC activation and PNI. These findings present a novel mechanism that may be targeted for the treatment of pancreatic cancer PNI.Statement of SignificanceIdentifying pancreatic tumor extracellular vesicles as key players in Schwann cell activation and perineural invasion by way of IL-8 will educate for more specialized and effective targets for an under-valued disease.
Political connection as a double-edged sword: the case of tax aggressiveness practice during the COVID-19 pandemic
Authors: Rudyanto Astrid , Julisar Julisar , Debora Debora 
Published: June 2023

PurposeThis research aims to examine the association between political connection and tax aggressiveness during the COVID-19 pandemic and the role of business ethics in the association between political connection and tax aggressiveness.Design/methodology/approachThis study employs a multiple regression method for 147 manufacturing firms listed on the Indonesia Stock Exchange during the pandemic era.FindingsPolitical connection has no association with tax aggressiveness. However, political connection has a negative (positive) association with tax aggressiveness in more (less) ethical firms. The results are robust after controlling for year-fixed effects, endogeneity issues and other tax aggressiveness measurements.Originality/valuePolitical connection is often cited as the driver of unethical business, including tax aggressiveness. However, this paper claims and finds that political connection is a double-edged sword. Ethical firms use political connection to reduce their tax aggressiveness, and vice versa. Previous research has paid little attention to this topic. This paper also uses COVID-19 as a natural experiment to highlight the importance of corporate social responsibility activities as business ethics.
Active BIM system for optimized multi-project ready-mix-concrete delivery
Authors: Begić Hana , Galić Mario , Klanšek Uroš 
Published: June 2023

PurposeReady-mix concrete delivery problem (RMCDP), a specific version of the vehicle routing problem (VRP), is a relevant supply-chain engineering task for construction management with various formulations and solving methods. This problem can range from a simple scenario involving one source, one material and one destination to a more challenging and complex case involving multiple sources, multiple materials and multiple destinations. This paper presents an Internet of Things (IoT)-supported active building information modeling (BIM) system for optimized multi-project ready-mix concrete (RMC) delivery.Design/methodology/approachThe presented system is BIM-based, IoT supported, dynamic and automatic input/output exchange to provide an optimal delivery program for multi-project ready-mix-concrete problem. The input parameters are extracted as real-time map-supported IoT data and transferred to the system via an application programming interface (API) into a mixed-integer linear programming (MILP) optimization model developed to perform the optimization. The obtained optimization results are further integrated into BIM by conventional project management tools. To demonstrate the features of the suggested system, an RMCDP example was applied to solve that included four building sites, seven eligible concrete plants and three necessary RMC mixtures.FindingsThe system provides the optimum delivery schedule for multiple RMCs to multiple construction sites, as well as the optimum RMC quantities to be delivered, the quantities from each concrete plant that must be supplied, the best delivery routes, the optimum execution times for each construction site, and the total minimal costs, while also assuring the dynamic transfer of the optimized results back into the portfolio of multiple BIM projects. The system can generate as many solutions as needed by updating the real-time input parameters in terms of change of the routes, unit prices and availability of concrete plants.Originality/valueThe suggested system allows dynamic adjustments during the optimization process, andis adaptable to changes in input data also considering the real-time input data. The system is based on spreadsheets, which are widely used and common tool that most stakeholders already utilize daily, while also providing the possibility to apply a more specialized tool. Based on this, the RMCDP can be solved using both conventional and advanced optimization software, enabling the system to handle even large-scale tasks as necessary.
Do corporate social responsibility practices have an impact on employer attractiveness – an approach to corporate volunteering programs
Authors: Seara Margarida , Proença Teresa , Ferreira Marisa R. 
Published: June 2023

PurposeThe purpose of this study is to understand the impact that Corporate Social Responsibility (CSR) practices have on the perceived attractiveness of companies in the eyes of their employees and potential candidates. Moreover, this study assesses the mediation role that Extrinsic (EA) and Intrinsic Attributions (IA) about Corporate Volunteering (CV) have on this relationship.Design/methodology/approachThree hundred and five responses were collected in an online questionnaire and a Structural Equation Modelling model was designed to explain the proposed relationships of the variables under study.FindingsThe authors found that the IA that employees/candidates make about CV programs have a direct and positive impact on the company’s attractiveness; it was not possible to conclude the same about EA.Originality/valueUnlike studies already existing in the area of corporate attractiveness that focus on the perspective of companies and customers, with a high focus on the organizational implementation of CSR and organizational benefits, this study has adopted a different perspective that focuses on the opinion of company employees, as well as the perspective of possible candidates. By not limiting participation to anyone, it covers a wide range of participants, allowing a broader knowledge of the labor market.
Evaluation of employment quality of college graduates based on interval MULTIMOORA with combination weights
Authors: Xie Jialiang , Wang Wenxin , Chen Yanling , Li Feng , Liu Xiaohui 
Published: June 2023

PurposeThe purpose of this paper is to develop a novel interval Multi-Objective Optimization by a Ratio Analysis plus the Full Multiplicative Form(MULTIMOORA) with combination weights to evaluate the employment quality of college graduates, where the criteria are expressed by interval numbers and the weights of criteria are completely unknown.Design/methodology/approachFirstly, considering the subjective uncertainty of the weights of the criteria, the interval best worst method (I-BWM) was present to determine the subjective weights of the criteria. Secondly, by the improved interval number distance measure, an improved interval deviation maximization method (I-MDM) was introduced to detemine the objective weights. In the following, based on the I-BWM and the improved I-MDM, a combination weighting method that takes into account the subjective and objective weights is proposed. Finally, a multi-criteria decision-making method based on the interval MULTIMOORA with combination weights is present to evaluate the employment quality of college graduates, and then a comparative analysis with some of the existing distance measures of interval numberswas conducted to illustrate the flexibility.FindingsAccording to the data of the Report on Employment Quality of Chinese College Graduats released by Mycos Research Institute in 2016–2020 and 2021–2022, the proposed method was used to evaluate the employment quality of college graduates during the period before and after the COVID-19 epidemic. The results verify that the method is more reasonable because the subjective and objective weights of the criteria can be fully considered. Finally, the feasibility and practicability of the proposed method are further verified by varying parameters.Originality/valuePresent an evaluation method on the employment quality of college graduates based on the Interval MULTIMOORA with combination weights considering the subjective and objective weights. And the proposed method is proved that it can provide a more reasonable evaluation results. At the same time, it is verified that the feasibility and the practicability of the proposed method are affected by varying parameters in the paper.
Tax incentives and upward R&D manipulation – evidence from the R&D tax deduction policy in China
Authors: He Yanan , Zhang Xindong , Hao Panpan , Dai Xiaoyong , Xue Haiyan 
Published: June 2023

PurposeThis paper investigates whether China's R&D tax deduction policy triggers firms to manipulate their R&D expenditures upward.Design/methodology/approachThis paper employs the ratio of actual tax savings as a proxy for the benefits of the R&D tax deduction policy based on manually collected and systematically cross-checked data. The relationship between tax benefits and abnormal R&D spending is estimated in a sample of Chinese A-share listed companies for the period 2007–2018.FindingsThe findings suggest that tax deductions lead to positive abnormal R&D spending and that this deviation in R&D spending may be attributed to firms' upward R&D manipulation for tax avoidance. The results also indicate that this behavior is more significant for the period after the policy revision, in non-HNTEs (high and new technology enterprises), and in firms with a high ratio of R&D expenses.Research limitations/implicationsIt is difficult to establish a sophisticated and unified model to identify the specific strategy of upward R&D manipulation that firms use to obtain tax benefits.Practical implicationsManagers should take into account upward R&D manipulation when designing governance mechanisms. Policymakers in developing countries may further pursue preferential tax policies that cover every stage of innovation activities gradually; the local provincial governments need to leverage their proximity and flexibility advantages to develop a tax collection and administration system.Originality/valueThis study contributes to the understanding of the complex effect of R&D tax incentives and helps more fully illuminate firms' upward R&D manipulation behavior from the perspective of tax planning strategies, which are underexplored in previous research.