bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria
Authors: van den Biggelaar Robin H.G.A. , Walburg Kimberley V. , van den Eeden Susan , van Doorn Cassandra L.R. , Meiler Eugenia , de Ries Alex S. , Fusco M. Chiara , Meijer Annemarie H. , Ottenhoff Tom H.M. , Saris Anno 
Published: August 2023

AbstractThe emergence of antimicrobial resistance has created an urgent need for alternative treatment strategies against deadly bacterial species. In this study, we investigated the potential of kinase inhibitors as host-directed therapies (HDTs) for combating infectious diseases caused by intracellular bacteria, specificallySalmonellaTyphimurium (Stm) andMycobacterium tuberculosis(Mtb). We screened 827 ATP-competitive kinase inhibitors with known target profiles from two Published Kinase Inhibitor Sets (PKIS1 and PKIS2) using intracellular infection models forStmandMtb, based on human cell lines and primary macrophages. Additionally, thein vivoefficacy of the compounds was assessed using zebrafish embryo infection models. Our kinase inhibitor screen identified 14 hit compounds forStmand 19 hit compounds forMtbthat were effective against intracellular bacteria and non-toxic for host cells. Further validation experiments showed the high efficacy of mostStmhit compounds and their ability to fully clear the intracellular infection both in cell lines and primary human macrophages. From these, two structurally relatedStmhit compounds, GSK1379738A and GSK1379760A, exhibited significant effectiveness againstStmin infected zebrafish embryos. Compounds that were active against intracellularMtbincluded morpholino-imidazo/triazolo-pyrimidinones that specifically target the kinases PIK3CB and PIK3CD as well as 2-aminobenzimidazoles targeting BLK, ABL1 and TRKA. Overall, this study provided insight into critical kinase targets acting at the host-pathogen interface and identified novel kinase inhibitors as potential HDTs for intracellular bacterial infections.
Extracellular Matrix Proteins Changes in the Left Ventricular Unloading and Overloading after Myocardial Infarction
Authors: Mavropoulos Spyros A. , Sakata Tomoki , Mazurek Renata , Ravichandran Anjali J. , Marx Jonas M. , Ishikawa Kiyotake 
Published: August 2023

AbstractBackgroundThe cardiac extracellular matrix (ECM) is a dynamic scaffold that transmits and responds to forces that act on the heart during the cardiac cycle. While acute left ventricle (LV) unloading by percutaneous LV assist device (pLVAD) is now a therapeutic option, its impact on ECM is unknown. We hypothesize that the composition of LV ECM proteins changes in response to reduced wall stress with mechanical LV unloading.MethodsTen Yorkshire pigs underwent myocardial infarction, and one week later were subjected to either 2 hours of LV unloading with pLVAD or 2 hours of LV overloading by mechanically-induced acute aortic regurgitation. Non-ischemic remote myocardium was processed for ECM specific proteomics. Volcano plots were constructed to determine differentially expressed proteins between the groups. Gene ontology (GO) analysis was performed to identify associated molecular processes and biological functions. Immunofluorescence microscopy was performed to validate differential protein expression.ResultsOf the 986 proteins analyzed, 39 were significantly differentially expressed between overloaded and unloaded myocardium. GO analysis by molecular function revealed that differences tending towards RNA binding and lipid binding proteins. Analysis by biological process showed that cell differentiation, vesicle transport, and programmed cell death were the processes most affected. Staining for three of the identified differentially expressed proteins had results congruent with proteomic analysis.ConclusionsThere were significant differences in the protein composition of the cardiac ECM between acutely unloaded and overloaded myocardium, suggesting that it actively responds to altered LV load.
Identifying key factors that encourage vegetable intake by young adults: using the health belief model
Authors: Hartwell Heather , Bray Jeff , Lavrushkina Natalia , Lacey Jodie , Rodrigues Vanessa Mello , Fernandes Ana Carolina , Bernardo Greyce Luci , Martinelli Suellen Secchi , Cavalli Suzi Barletto , Proença Rossana Pacheco da Costa 
Published: August 2023

PurposeAdequate vegetable consumption is fundamental to a healthy balanced diet; however, global compliance with recommendations is poor which is particularly important for young adults as they form food consumption habits. There is a growing interest in the circular economy of hospitality and sustainability of current dietary patterns in light of climate change and an expanding global population. The food value chain needs to be considered both vertically and horizontally where the research and development (R&D) investment is optimised by being “joined up” and not fragmentary; in addition, consumer trade-offs of health vs for example sensory appeal are taken into consideration. The purpose of this study was to identify factors predicting acceptance of vegetable dishes by young adults and present a roadmap that can be used for dish development and healthful marketing.Design/methodology/approachThis study used the health belief model (HBM) as framework to investigate key factors that encourage vegetable intake by young adults using an online questionnaire sample of 444 enrolled in undergraduate programs at universities in Brazil.FindingsStructural modelling showed that vegetable consumption frequency was positively influenced by Health concerns, Naturalness and Self-efficacy (including cooking skills), whereas Sensory factors and Familiarity demonstrated a negative loading that might be related to unpleasantness.Originality/valueGlobally, there is a strong need to promote the consumption of vegetables as a public health policy priority but also to ameliorate barriers to action that could be facilitated by availability, dish development and healthful marketing in hospitality operations.
Now what? An assessment of perceived legacies post-Olympic cycle
Authors: Feller Rodrigo , Turick Robert M. , Walker Khirey B. , Downs Benjamin J. 
Published: August 2023

PurposeThe purpose of this study is to examine the post-event perceptions of Rio de Janeiro residents regarding the legacies left to them from hosting the 2016 Olympic Games. Additionally, this study examines how perceptions of Olympic legacies differed amongst demographic groups.Design/methodology/approachUtilizing a mixed-methods approach, participants were asked to complete a survey questionnaire and answer three open-ended questions. An adapted version of Fredline et al. (2003)'s General Scale to Measure Social Impacts (GSMSI) was selected for this study. In total, 156 useable responses were collected. An exploratory factor analysis was utilized for the survey items while the three open-ended questions were coded abductively as positive, negative or mixed feelings.FindingsThe quantitative results shows that Rio residents believe that hosting the 2016 Olympic Games had a mostly negative impact on their perception of legacies. Through reading open-ended responses, participants expressed disappointment over the legacies left to them. These findings suggest that hosting the Olympic Games may not have been beneficial to the life of Rio de Janeiro residents, and it may have been particularly worse for members of the middle class.Originality/valueDue to the recency of the Rio 2016 Olympic Games, a few studies have explored the long-term legacies left to the local population. However, the uniqueness of this study lays on the perceptions of legacies from hosting the Rio 2016 after a full Olympic cycle has passed.
Readiness of lean sustainability in healthcare organizations
Authors: Thomas Albi , Suresh M. 
Published: August 2023

Purpose
This paper aims to “identify,” “analyse” and “categorise” the readiness factors of lean sustainability in health-care organisation using total interpretive structural modelling (TISM).

Design/methodology/approach
To obtain the data, a closed-ended questionnaire was used in addition to a scheduled interview. To identify how the factors interact, the TISM approach was used, and the matriced’ impacts croise’s multiplication applique’e a UN classement (MICMAC) analysis was used to rank and categorise the lean sustainability readiness factors.

Findings
This study identified ten lean sustainability readiness factors for health-care organisation. The identified factors are resources utilization practice (F1), management commitment and leadership (F2), operational flexibility (F3), workforce engagement and time commitment (F4), sustainability motivational factors (F5), awareness of lean and sustainable practice (F6), hospital design (F7), energy efficiency practices in hospitals (F8), responsible autonomy (F9) and new system adoptability training (F10). The key/driving factors are identified in this study are operational flexibility, sustainability motivational factors, management commitment and leadership, new system adoptability training.

Research limitations/implications
The study focussed primarily on lean sustainability factors for the health-care sector.

Practical implications
This research will aid key stakeholders and academics in the better understanding the readiness factors that influence lean sustainability in health-care organisation. This study emphasises the factors that must be considered when applying lean sustainable practices in health care as a real-world application in a health-care organisation. These readiness factors for lean sustainability can be used by an organization to comprehend more about the concept and the components that contribute to health-care lean sustainability.

Originality/value
This study proposes the TISM technique for health care, which is a novel attempt in the subject of lean sustainability in this sector.
What do we know about real earnings management in the GCC?
Authors: Alghemary Mahmoud , Al-Najjar Basil , Polovina Nereida 
Published: August 2023

PurposeThe authors empirically investigate the association between acquisition, ownership structure and accrual earnings management (AEM) on real earnings management (REM) using Gulf Cooperation Council (GCC)-listed firms' context.Design/methodology/approachThe authors' sample consists of 1,892 firm-year observations for the period from 2007–2017, and the authors adopt a panel data approach in investigating the interrelationships in this study. The authors employ different econometrics approach to test the authors' hypotheses.FindingsThe findings reveal that acquiring companies engage more in AEM if compared to REM. In terms of ownership structure, institutional ownership and state ownership mitigate the engagement in REM, whereas foreign ownership is found to be an ineffective mechanism in reducing engagement in REM. The authors report similar findings on ownership structure for AEM. The authors also find that the GCC firms engage more in REM when the firms engage in AEM, suggesting a complementary relation between these two earnings management techniques. These findings are robust after controlling for different aspects including any endogeneity issue in the authors' models.Originality/valueThe authors' research highlights the importance of understanding REM and AEM dynamics in GCC context. Also, the authors' findings on ownership structure suggest that GCC-listed firms can gain from institutional and state ownership which restricts earnings management, improving firm transparency and subsequently impacting firm performance.
An integrative model for online community citizenship behavior of luxury fashion brands on Instagram
Authors: Hsu Li-Chun 
Published: August 2023

PurposeThis study explores the creation of online brand relationships from the personal, social and brand perspectives of social media and its influence on the community citizenship behavior to establish an integrative model. With social identity theory (SIT) and the theory of socially shared cognition (TSSC) as the theoretical basis for model integration, this study identifies the key factors that maintain the relationship between online community members and brands and prompt brand members to establish a close emotional connection with the brand and generate community citizenship behavior for the brand.Design/methodology/approachThis study examines community members who own products from luxury fashion brands (e.g. Louis Vuitton, Chanel and Hermès) and have followed the official Instagram account of the luxury fashion brand for at least 1 year, with a total of 582 valid samples. Structural equation modeling (SEM) is used to test the model.FindingsAll except for one of the hypotheses are supported, and the theoretical model exhibits acceptable goodness-of-fit. The strongest effect is that of brand community identification on affective brand commitment, followed by that of online co-creation on community citizenship behavior and that of brand commitment on community citizenship behavior.Originality/valueSIT was used as the basis and extended to the TSSC to integrate the theoretical perspectives. This study identifies the online brand relationship between service providers and consumers, explores possible causes and consequences from multiple perspectives and proposes conclusions and practical management implications as references for marketing personnel.
Firm capabilities, use of Internet technologies and export performance: an empirical study of Polish exporters
Authors: Trąpczyński Piotr , Kawa Arkadiusz 
Published: August 2023

PurposeThe objective of the paper is to examine the effects of firm capabilities on the use of Internet technologies, as well as the effect of the use of Internet technologies on export performance, by drawing from the resource-based view (RBV) and the information systems literature.Design/methodology/approachThe authors test their propositions by using structural equation modelling (SEM) for 165 Polish exporters from the industrial manufacturing sector.FindingsThe authors’ findings indicate that the use of Internet technologies is positively related to the possessed capabilities of the firms. The use of Internet technologies is in turn positively related to export performance. The authors also find partial evidence for the fact notion that these relationships are moderated by the technology intensity of the sector.Research limitations/implicationsFirms which develop capabilities utilizing Internet technologies are able to enhance both communication and distribution efficiencies which in turn improve the effectiveness of their international operations.Practical implicationsManagers, particularly in sectors with a higher technological intensity, can find these findings useful as the study indicates where they should allocate their efforts to manage various Internet technologies activities for better export performance.Originality/valueExisting literature has focused predominantly on the application of Internet technologies in the area of e-commerce. The authors go a step further in enhancing the understanding of digitalization in the business models of exporting firms by accounting for a broad variety of Internet-based technologies used by exporters.
The nexus between peace and mental well-being: contributions for public happiness
Authors: Marujo Helena Á 
Published: August 2023

Purpose
This underscores individual and social implications for how mental disorders and mental well-being are constructed, conceived of and treated. Further, this paper aims to examine positive psychology’s role in supporting the advancement of a broader systemic and contextual approach to mental health. With that aim, this paper connects data on mental health and well-being with peace studies to describe the systems of value and social ecologies underpinning mental disorders, using public happiness/Felicitas Publica as a possible framework to enhance public mental health while intervening at the local level (Bruni and Zamagni, 2007; Marujo and Neto, 2013, 2014, 2016, 2017, 2021; Marujo et al., 2019).

Design/methodology/approach
Theoretical foundations and data on positive peace and mental well-being are described with the intention to propose a systemic, contextual, relational, communitarian, economic and sociopolitical perspective of well-being that goes beyond individual bodies and/or brains and, instead, views mental disorder and mental health as social currency (Beck, 2020).

Findings
The interventions using dialogic, conversational and community approaches are a possible path to promote peace, mental health and public happiness.

Research limitations/implications
Examining the interplay between the fields of positive psychology, mental health and cultures of peace, this work contributes to the broadening of research and subsequent intervention topics through transdisciplinary approaches while reinforcing the role of systemic and social determinants and complementing the prevalent medical model and intraindividual perspective of mental health and well-being.

Practical implications
Adopting positive psychology to address mental health through public happiness concepts and interventions opens opportunities to respond to the ebb and flow of social challenges and life-giving opportunities. Therefore, the paper intends to articulate actor-related, relational, structural and cultural dimensions while moving away from discrete technocratic and individual models and pays attention to the way their implementations are aligned with both individual and social needs.

Social implications
The work offers an inclusive, equalitarian, politically sensitive approach to positive mental health and positive psychology, bringing forward a structural transformation and human rights-based approach perspective while rethinking the type of social and political solutions to mental health issues.

Originality/value
Creating a critically constructive debate vis-à-vis the fluidity and complexity of the social world, the paper examines mental health and positive psychology simultaneously from a “hardware” (institutions, infrastructures, services, systems, etc.) and a “software” (i.e. individuals and community/societal relations).
Mandatory carbon reporting, voluntary carbon disclosure and ESG performance
Authors: Jiang Yan , Tang Qingliang 
Published: August 2023

Purpose
This study aims to examine the impact of mandatory adoption of The Act 2013 in UK on voluntary carbon disclosure. Mandatory adoption of The Act 2013 in UK is a compelling setting to examine this research question because it is an exogenous imposed event and is unlikely to be affected by disclosure choice.

Design/methodology/approach
This study uses a difference-in-differences research design to examine the impact of mandatory adoption of The Act 2013 in UK on voluntary carbon disclosure. The treatment sample includes 451 UK firms subject to mandatory adoption of The Act 2013, and the control sample includes firms from 15 EU countries that did not mandate adoption during the sample period.

Findings
The authors document an increase in the quantity and quality of voluntary carbon disclosure following adoption of The Act 2013 in the treatment sample relative to the control sample. They also find that firms with better environmental, social and governance (ESG) performance experience a highly significant increase in voluntary carbon disclosure after adoption of The Act 2013. For firms from carbon-intensive vs less-carbon-intensive sectors, the results suggest that firms in carbon-intensive sectors experience a greater increase in the propensity of voluntary disclosure after adoption of The Act.

Originality/value
The authors examine the impact of mandatory adoption of The Act 2013 in UK on voluntary carbon disclosure and the impact of firms’ ESG activity on the relationship between voluntary and mandatory carbon disclosure. To the best of the authors’ knowledge, this insight has never been documented in the literature.
Damage in a saguaro (Carnegiea gigantea) population in the El Pinacate and Gran Desierto de Altar Biosphere Reserve, Sonora, Mexico
Authors: Jiménez‐Sierra Cecilia L. , Arroyo‐Pérez Erika , Matias‐Palafox María Loraine , Torres‐Orozco Daniel , Burgos‐Solorio Armando , Quintanar‐Isaías Alejandra , González‐Adán María de los Ángeles , Vázquez‐Quesada Benito 
Published: August 2023

AbstractThe saguaro is an endemic and emblematic columnar cactus of the Sonoran Desert that offers refuge and food to different species. Climate change and increased ultraviolet exposure are threatening this species. Although reports of an increase in “epidermal browning” in saguaro populations in the United States have been published, to the best of our knowledge, no studies of this or other types of damage to Mexican saguaro populations are available. The present research is the first report of its kind performed in a saguaro population in the El Pinacate and Gran Desierto de Altar Biosphere Reserve (Sonora, Mexico). Seven types of damage were evaluated and classified in saguaro stems: cactus cortical scaling (CCS = epidermal browning), girdling, shell, exposed root, eyelet, termite tubes, and topping cuts. In addition, an anatomical comparison of healthy and CCS‐damaged tissues is presented. Shell was the most frequent type of damage (91% of individuals), followed by CCS (73%). Girdling occurred mainly in small organisms. Shell, exposed root, eyelet, and termite tubes tended to occur more frequently in larger organisms, whereas CCS tended to be more evenly distributed among differently sized individuals. Of all individuals, 3.3% were undamaged, 89.2% were moderately damaged, and 7.5% were highly damaged. CCS damage causes differences in the composition of the tissues, as well as in stomata distribution, thus compromising the photosynthetic function of the stem. The snapshot of the state of the individuals provided in the present study highlights the need for longer‐term studies considering the long life cycle of the saguaro to develop conservation strategies.
Becoming Buddhists: The emergence of a prestigious temple
Authors: Zheng Enying 
Published: August 2023

AbstractHow does a novel organizational prototype come about and succeed to the point where it becomes recognized as an icon? To address this question, this article examines the organizational emergence of a prestigious temple. Drawing on interviews and content analysis of 6320 blog entries between 2006 and 2018, we identify how an organized way of practicing Buddhism emerged in China and trace its founding monks to students from two elite universities. We argue that organizational emergence—in this case the rise of a prestigious temple and what it stands for—was manifested by identity claims of “who we are” to audiences. Declaring “who we are not” prior to establishing this temple, the founding monks subsequently claimed their organizational identity in three distinct stages: who we are in this temple, who we are as a temple, and who we are as Buddhism. As these identity claims were recognized by the audiences, a novel Buddhist organization emerged. This article contributes to an organizational perspective of religious study and provides a focused case with sufficient temporary variations to explore how identity claims facilitate organizational emergence. It has important implications for understanding incremental yet fundamental institutional changes, as it provides a template of organized religion that nurtures social skills for self‐organizing. More broadly, these insights contribute toward developing a vibrant civil society.