bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women’s experiences of living with adenomyosis and perceptions of the diagnostic journey: a scoping review
Authors: Taylor Margaret A , Croudace Tim J , Muir Fiona E , McBride Margot 
Published: January 2025

ObjectivesUterine adenomyosis is a common gynaecological disease that can be debilitating. It is poorly understood and may be overlooked in clinical settings. A research gap exists as there are currently no published scoping reviews on perceptions and experiences early in the illness course. As part of a professional doctorate thesis, the aim of this review is to systematically retrieve and describe available literature, exploring the impact of living with adenomyosis and perceptions of the diagnostic journey.DesignA scoping review is conducted using JBI methodology.Data sourcesMedline, CINAHL Plus, Web of Science, Google Scholar, Cochrane library, JBI and PROSPERO databases, EThOS online and Google. Searches were made from database inception to July 2023.Eligibility criteriaThe characteristics of the evidence sourced were deliberately broad. Studies exploring the experiences and perceptions of women diagnosed with adenomyosis were considered.Data extraction and synthesisTitles and abstracts were initially screened. Subsequently, eligibility was clarified through methods section inspection, and the remaining studies were read in depth. A manual hand-search of references of selected studies was conducted. Prespecified data were extracted, charted and categorised into themes.ResultsSix eligible studies were found, with themes describing impact and burdens, as well as several categories of unsupported needs. No studies specifically focused on perceptions of the diagnostic journey, but some eligible studies made minor reference to this and are included.ConclusionsThis review highlights the profound impact of adenomyosis and is the first to explore the lived experiences and the diagnostic journey. Understanding the burdens of disease in terms of perceptions and lived experience in combination with the experiences of diagnostic interactions is vital to improving diagnostic pathways. Education with improved multidisciplinary collaboration and further qualitative and case study research will be crucial to achieve this goal.RegistrationA priori protocol was registered (https://doi.org/10.17605/OSF.IO/2UDYN) and published (https://doi.org/10.1136/bmjopen-2023-075316).
A nested case-control study evaluating the relationship between adverse childhood experiences and immune-mediated inflammatory disease in the Canadian Longitudinal Study on Aging
Authors: O'Mahony Julia , Bernstein Charles N , Marrie Ruth Ann 
Published: January 2025

ObjectiveAdverse childhood experiences (ACE) have inconsistently been implicated as risk factors for immune-mediated inflammatory diseases (IMID). We evaluated whether the association of ACE with disease differs between IMID and other chronic diseases.DesignNested retrospective case-control study.SettingWe used data from the Canadian Longitudinal Study on Aging (CLSA), which recruited participants aged 45–85 years between 2010 and 2015.ParticipantsWe included 12 627 CLSA participants: 2 102 who reported diagnoses of IMID (258 multiple sclerosis (MS), 1 692 rheumatoid arthritis (RA) and 160 inflammatory bowel disease (IBD)), 5 519 with diabetes, 170 with epilepsy, 3 889 with asthma and 1 125 with no chronic diseases. ACE, including childhood maltreatment (physical, emotional and sexual abuse, neglect) and household dysfunction, were queried using questions from the Childhood Experiences of Violence Questionnaire-Short Form and the National Longitudinal Study of Adolescent to Adult Health Wave III questionnaire.Primary and secondary outcome measuresWe first evaluated whether the association of maltreatment differed across diagnoses (IMID, diabetes, asthma, epilepsy, no chronic diseases). Second, we evaluated whether the association between maltreatment differed across IMID. We repeated our analyses for different types of ACE.ResultsMaltreatment or household dysfunction was experienced by 64% of participants and 30% experienced both. On multivariable analysis, history of any maltreatment, sexual abuse, any household dysfunction and having ≥3 types of ACE were all associated with increased risk of IMID compared with no chronic disease. The association between ACE and IMID did not differ across MS, RA and IBD.ConclusionACE are common among Canadians with and without chronic diseases. History of any maltreatment or household dysfunction is associated with increased risk of chronic disease.
Effectiveness of the ARTHE-e app for exercise adherence in people with knee osteoarthritis: protocol for a randomised controlled trial
Authors: Pelletier-Visa Mathilde , Dobija Lech , Bonhomme Alexis , Lanhers Charlotte , Pereira Bruno , Coudeyre Emmanuel 
Published: January 2025

IntroductionOsteoarthritis, the most prevalent joint disease, poses a significant challenge due to its progressive nature and impact on the whole joint and periarticular structures. Although exercise is crucial for symptom improvement and progression slowdown, adherence to exercise programmes remains a concern. In response, we have developed a novel smartphone-based m-health application, ARTH-e, specifically designed to enhance adherence to adapted physical activity in individuals with knee osteoarthritis. We aim to perform a prospective,multicenter, randomized (1:1) controlled trial to compare the effectiveness of m-health application ARTH-e (intervention group) with standard care (control group) on exercise adherence in people with knee osteoarthritis. We hypothesise that adherence will be stronger among users of the ARTH-e application.Methods and analysisWe will recruit 120 participants from 5 hospitals in France. The participants will undergo a comprehensive assessment, including the Exercise Adherence Rating Scale (EARS) at 2, 4 and 6 months, Knee Injury and Osteoarthritis Outcome Score, Evaluation of the Perception of Physical Activity, Tampa Scale of Kinesiophobia, European Quality of Life 5 Dimensions and 3 Lines and a Visual Analogue Scale rating of pain at baseline and 6 months. Adherence will be monitored using a connected bracelet. The intervention group will use the ARTH-e application for 6 months, while the control group will follow stay-active advice from their physician. The primary outcome will be the difference between groups in the evolution of the EARS score at 6 months.Ethics and disseminationThe study has been approved by the medical ethics committee (Comité de Protection des Personnes) XI of Saint Germain en Laye (27 March 2024) (ID for ethics approval: 24.00330.000201). Eligible individuals will sign the informed consent form before enrolment. Study results will be reported in peer-reviewed publications and at scientific meetings.Trial registration numberNCT06359171.
Improving health outcomes by strengthening public sector capacity in social and behaviour change programming in Nigeria: a qualitative study
Authors: Adetunji Adetayo , Addo Bright , Abegunde Dele , Kalamar Amanda , Tulsiani Nrupa Jani , Sripad Pooja , Oyedokun-Adegbabo Foyeke , Ankomah Augustine 
Published: January 2025

ObjectiveThis paper examines the outcomes of the public sector capacity strengthening (PSCS) approach and how they contribute to the promotion of maternal, newborn, and child health, and nutrition (MNCH+N), family planning (FP) and malaria prevention-related outcomes.DesignThe qualitative study implemented from July to August of 2022 used the outcome harvesting methodology and key informant interviews to elicit information including most significant change (MSC) stories to evaluate project outcomes over 5 years (2017–2022).SettingThe study was conducted in Sokoto, Kebbi, Nasarawa, Bauchi and Ebonyi states of Nigeria.ParticipantsThe study focused on public sector stakeholders who were exposed to the PSCS intervention and were selected from government agencies. Nine study participants were engaged per state, bringing the total number of participants to 45. Data were analysed thematically and elicited MSC stories were analysed for content.ResultsThe PSCS approach empowered stakeholders at the individual level to disseminate MNCH+N, FP and malaria prevention messages, monitor health and social and behaviour (SBC) activities and increase the demand for health services. At the organisational level, the approach facilitated coordination of SBC activities, enabled training cascades and promoted adherence to health service guidelines. At the system level, it strengthened ward development committees to address health challenges. Challenges hindering stakeholders’ application of PSCS-acquired skills include inadequate workforce, negative attitudes of health workers, funding constraints, cultural barriers, lack of government ownership and limited accessibility.ConclusionsThis study shows that the PSCS approach is an effective model to scale up capacity for SBC in MNCH+N, FP and malaria prevention programmes. In response to documented supply-side challenges impeding the application of gained knowledge and skill, we recommend inclusive health worker recruitment, sensitisation programmes for health workers, government ownership, improved security, healthcare infrastructure and transportation systems.
Clinicopathological characteristics and survival outcomes of women aged ≤45 and >45 years with endometrial adenocarcinoma in tertiary referral hospital: a 21-year cohort study
Authors: Panyavaranant Pinyada , Rattanachaipipat Juthamas , Manchana Tarinee 
Published: January 2025

ObjectiveThis study aimed to compare clinicopathological characteristics and oncological outcomes in patients with endometrial cancer aged ≤45 and >45 years, with a focus on identifying distinct traits and prognostic factors in younger patients.DesignA retrospective cohort study.SettingThe study was conducted at King Chulalongkorn Memorial Hospital, Bangkok, Thailand, with a restricted study population from 1996 to 2016.ParticipantsA total of 1114 patients diagnosed with endometrial cancer and underwent surgery were strictly selected, excluding those who had received primary radiotherapy or had uterine sarcoma. Among the population, 188 patients (16.9%) were ≤45 years old and 926 patients (83.1%) were >45 years old.Outcome measuresThe primary outcome measures were disease-free survival (DFS) and overall survival (OS) at 5, 10 and 15 years, with an analysis of survival rates based on patient age groups and prognostic factors.ResultsYounger patients (≤45 years) displayed significantly higher rates of obesity, nulliparity and polycystic ovary syndrome (PCOS), as well as favourable pathological characteristics such as well-differentiated tumours and lower rates of myometrial invasion. They also exhibited better long-term survival outcomes, the DFS rates at 5, 10 and 15 years were 89.6% (95% CI: 84.0 to 98.3), 85.9% (95% CI: 79.0 to 90.6) and 76.8% (95% CI: 63.3 to 85.9), respectively, compared with 77.6% (95% CI: 74.6 to 80.2), 69.2% (95% CI: 65.6 to 72.5) and 53.5% (95% CI: 48.0 to 58.6) in the older group. Similarly, the OS rates at 5, 10 and 15 years were 94.7% (95% CI: 90.1 to 97.2), 91.7% (95% CI: 85.4 to 95.3) and 74.0% (95% CI: 51.7 to 87.2), respectively, compared with 86.9% (95% CI: 84.4 to 89.0), 76.6% (95% CI: 73.0 to 79.7) and 60.7% (95% CI: 55.0 to 65.8) in the older group. Independent prognostic factors consist of non-endometrioid histology, involvement of the lower uterine segment and cervix, omental metastasis, lymphovascular invasion and advanced stage.ConclusionsYoung patients with endometrial cancer exhibit distinct favourable clinicopathological characteristics associated with better oncological outcomes compared with older patients. However, certain aggressive disease features should be taken into consideration as they have a negative influence on prognosis significantly. These insights emphasise the need for targeted management strategies and further research.
Postpartum haemorrhage following vaginal delivery: a comprehensive analysis and development of predictive models for aetiological subgroups in Chinese women
Authors: Li Jinke , Zhang Dandan , Lin Hong , Shao Mengyuan , Wang Xiaoxue , Chen Xueting , Zhou Yangzi , Song Zixuan 
Published: January 2025

ObjectivesThis study aimed to dissect the aetiological subgroups of postpartum haemorrhage (PPH) that occur after vaginal delivery in women with full-term singleton pregnancies. Our goal was to craft and validate predictive models to guide clinical decision-making and optimise resource allocation.DesignA retrospective cohort study.SettingShengjing Hospital of China Medical University, Liaoning Maternal and Child Health Hospital, and Shenyang Women’s and Children’s Hospital.Participants29 842 women who underwent vaginal delivery were enrolled in the study across three hospitals from 2016 to 2022.Primary outcome measuresPPH, categorised into uterine atony (UA), placental factors (PF), cervical trauma (CT), and coagulation abnormalities (CA) by aetiology.ResultsThe logistic regression for overall PPH and UA-PPH showcased high discrimination (AUCs of 0.807 and 0.794, respectively), coupled with commendable calibration and DCA-assessed clinical utility, culminating in the development of a nomogram for risk prediction. The PF-PPH model exhibited a modest AUC of 0.739, while the CT-PPH and CA-PPH models demonstrated suboptimal clinical utility and calibration.ConclusionThe study identified factors associated with PPH and developed models with good performance for overall PPH and UA-PPH. The nomogram offers a valuable tool for risk prediction. However, models for PF-PPH, CT-PPH, and CA-PPH require further refinement. Future research should focus on larger samples and multicentre validation for enhanced model generalisability.
Developing a core outcome set for interventions in people with mild cognitive impairment: study protocol
Authors: Gabb Victoria Grace , Harding Sam , McNair Angus G K , Clayton Julie , Barrett-Muir Winsome , Richardson Alan , Woodward Natalie , Alderman Sophie , Dooley Jemima , Webb Joseph , Rudd Sarah , Coulthard Elizabeth , Turner Nicholas 
Published: January 2025

IntroductionThere is no standardised national guidance on clinical management for people living with mild cognitive impairment (MCI), and therapeutic interventions are limited. Understanding what outcomes are important and meaningful to people living with MCI and developing a core outcome set (COS) for research and clinical practice will improve the impact of clinical research and contribute towards developing effective care pathways for MCI. This study aims to develop a COS for adults living with MCI intended for use in interventional and clinical settings.Methods and analysisThe COS will be developed using a five-stage study design: (1) systematic literature search, (2) qualitative interviews, (3) evidence synthesis from stages 1 and 2, (4) two-round Delphi survey and (5) consensus meeting(s). First, we will conduct an umbrella review of existing MCI interventional studies and extract a list of outcomes. Qualitative interviews will be held with key stakeholders including individuals living with MCI, friends and family, and relevant professionals to identify further outcomes considered important. Outcomes from the review and interviews will be synthesised into a ‘long list’ of outcomes for potential inclusion in the COS. Two rounds of Delphi surveys followed by a consensus meeting will be used to reach stakeholder consensus on which outcomes should be included in the final COS.Ethics and disseminationWe have received ethical approval from the London—Queen Square Research Ethics Committee (23/PR/1580). Patient and public involvement and engagement are central to developing the COS. The results will be disseminated via conferences, peer-reviewed publications, briefing notes to key agencies, to the public via social media and blog posts and directly to stakeholders who participate in the project.Trial registration numberCore Outcome Measures in Effectiveness Trials Initiative 2117; PROSPERO registration: CRD42023452514.
Admission outcomes and their associated factors among children admitted to the paediatric emergency unit within 24 hours of Dilla University Referral Hospital, Ethiopia, 2023: a cross-sectional study
Authors: Dube Samuel Jigso , Seboka Binyam Tariku , Demeke Abel Desalegn , Feleke Mekdes Mekonnen , Jarso Abdo Hajo , Bati Asresu Feleke , Udo Etaferaw , Markos Selam Tadele , Kassaw Chalachew , Yeheyis Tomas , Debebe Amdehiwot Aynalem , Gechere Ephrem Geja , Dessie Yihenew Ayehu 
Published: January 2025

BackgroundChildren in paediatric emergency units are those who need special attention, and unless treated early, they are a vulnerable population to unwanted outcomes like death, discharge against medical advice or referral to other institutions within 24 hours.ObjectivesTo assess admission outcomes and their associated factors among children admitted to the paediatric emergency unit of Dilla University Referral Hospital, Ethiopia, 2023.MethodsAn institution-based cross-sectional study design was employed among children admitted to the paediatric emergency unit at Dilla University Referral Hospital from 8 May 2023 to 8 June 2023. A total of 885 complete charts of the children aged 29 days to 14 years were analysed. Structured checklist was used for data collection. STATA V.14 was used for data analysis. A multinomial logistic regression model was used to determine the factors associated with admission outcomes. Overall model fitness was checked using the likelihood ratio test.ResultOut of 885 patient charts reviewed, the magnitude of patients improved, transferred, died, referred and discharged against medical advice was 51%, 40.9%, 7.6%, 0.1% and 0.4%, respectively. Children presented with diarrhoea (adjusted OR (AOR) =2.92, 95% CI 1.46 to 5.84), severe respiratory distress (AOR=5.08, 95% CI 2.49 to 10.35), coma (AOR=3.71, 95% CI 1.24 to 11.13), comorbidity (AOR=3.33, 95% CI 1.49 to 7.41) and delay to seek healthcare (AOR=1.99, 95% CI 1.03 to 3.83) were significantly associated factors with emergency unit mortality, whereas pneumonia (AOR=1.76, 95% CI 1.16 to 2.65) and severe acute malnutrition (AOR=3.46, 95% CI 2.06 to 5.81) were significantly associated factors with intrahospital unit/ward transfer.ConclusionThe magnitude of mortality, transfer to the ward and discharge against medical advice were relatively higher. Interventions focused on early diagnoses, and the initiation of appropriate treatments was of the utmost relevance to improving patient outcomes.
How faculty with critical care specialties learn in a university hospital: a qualitative phenomenological study
Authors: Jeong Hyeyoon , Cho Hyena , Seo Kyoung-Woo , Lee Janghoon , Kim Miran , Yu Jihye 
Published: January 2025

ObjectivesThe study aims to explore the workplace learning experiences of medical faculty in critical care specialties at a university hospital, focusing on how they develop their professional identity and construct the meaning of their work.DesignQualitative, phenomenological study.SettingThe current study was conducted at a university hospital in South Korea between November 2022 and October 2023.ParticipantsFive faculty members (two males and three females) from critical care specialties (eg, emergency medicine) with over 15 years of experience, each having served as faculty at a university hospital for more than 5 years.ResultsSix key themes emerged: cultivating ‘doctor-ishness’ in the realm of critical care, beacon of inner drive: guiding professional growth, nexus for leveraging expertise and fostering professional growth, the challenging reality of becoming an ‘ideal’ faculty, the shifting tides of the medical profession’s role and weaving workplace learning into a unique rhythm of practice. These themes collectively highlight that faculty members’ workplace learning involves a transition from functional professionals to reflective practitioners.ConclusionsWorkplace learning of faculty members with critical care specialties is understood as an ongoing, context-dependent and individualised process in which emotions play a crucial role in determining the depth and significance of learning and shaping professional identities. This study highlights their capacity for agency and potential, offering a perspective beyond previous research that has primarily focused on their hardships. By shedding light on their workplace learning from an insider’s view and underscoring the need to support professional development in these high-stakes fields, our findings suggest theoretical and practical interventions to foster the mutual growth of faculty and hospital organisations.
Implementing an intrahospital transport preparation (IHT) and management project for critically ill patients: identification of barriers and facilitators using consolidated framework for implementation research (CFIR) – a qualitative study
Authors: Wang Jing , Zhang Xiaotian , Li Guifen , Lu Ying , Xie Rui , Cui Man , Li Baohua , Du Lanfang , Ma Li 
Published: January 2025

ObjectiveTo investigate the factors contributing to or hindering intrahospital transport preparation and management projects using the consolidated framework for implementation research (CFIR) framework.DesignSemistructured interviews were used in a qualitative descriptive study.SettingThis study was conducted in the emergency room of a tertiary hospital in Beijing, China, between December 2023 and January 2024.ParticipantsPurposive sampling was employed to recruit 22 doctors and nurses involved in intrahospital transport.Primary and secondary outcome measuresA content analysis technique was employed to transcribe and analyse all gathered data. Iterative methods were used for the data collection and analysis.Results39 implementation determinants—11 barriers, 25 facilitators and 3 neutral factors—were identified. These determining factors aligned with 23 of the 26 CFIR constructs and 5 CFIR domains. Facilitators were identified in four primary domains: ease of implementation, scientific and project completion, patient advantages and enhanced capacity for safe and professional transfer. Additionally, hurdles were identified in the CFIR domains of intervention characteristics, outer settings and inner settings. These barriers include inadequate training and mobilisation, insufficient information systems, unclear reward and punishment policies, a shortage of labour and material resources and the absence of established reward and punishment laws.ConclusionThis study identified the factors influencing the emergency department’s intrahospital transport planning and management project implementation. Despite numerous obstacles, the project provides a clear pathway for advancing intrahospital transport planning and management.