bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of the spatial and temporal distributions of tidal flat surface sediment based on multitemporal remote sensing
Authors: Zhang Nan , Li Huan , Zhang Jiabao , Chen Jiayin , Wu Hongbo , Gong Zheng 
Published: January 2023

IntroductionThe ecological environment of tidal flats often changes due to tidal erosion and sedimentation. The distribution of tidal flat surface sediment is a natural reflection of the changes in the external dynamic environment, the spatial and temporal distribution pattern is of great significance.MethodsIn this study, the output structure of traditional convolutional neural network is combined with BP neural network. Meanwhile, four phases of Sentinel-2 multispectral images were collected and combined with field data from the Doulonggang tidal flat in Jiangsu Province, China, to construct the sediment composition inversion model.ResultsThe inversion accuracy was higher than 80% compared with the measured results. According to the inversion result, from 2017 to 2022, the surface sediment particle size of the tidal flat in Jiangsu varied seasonally and was coarse in summer and fine in winter. Additionally, the sediment composition tended to coarsen, showing an interannual change trend of increasing sand content and decreasing clay and silt contents.DiscussionThe above change of the sedimentary environment of the tidal flat may be caused by the decrease of fine grained sediment deposition, the introduction of exotic vegetation, the global sea level rise and the influence of human activities.
Biomarkers in long COVID-19: A systematic review
Authors: Lai Yun-Ju , Liu Shou-Hou , Manachevakul Sumatchara , Lee Te-An , Kuo Chun-Tse , Bello Dhimiter 
Published: January 2023

PurposeLong COVID, also known as post-acute sequelae of COVID-19, refers to the constellation of long-term symptoms experienced by people suffering persistent symptoms for one or more months after SARS-CoV-2 infection. Blood biomarkers can be altered in long COVID patients; however, biomarkers associated with long COVID symptoms and their roles in disease progression remain undetermined. This study aims to systematically evaluate blood biomarkers that may act as indicators or therapeutic targets for long COVID.MethodsA systematic literature review in PubMed, Embase, and CINAHL was performed on 18 August 2022. The search keywords long COVID-19 symptoms and biomarkers were used to filter out the eligible studies, which were then carefully evaluated.ResultsIdentified from 28 studies and representing six biological classifications, 113 biomarkers were significantly associated with long COVID: (1) Cytokine/Chemokine (38, 33.6%); (2) Biochemical markers (24, 21.2%); (3) Vascular markers (20, 17.7%); (4) Neurological markers (6, 5.3%); (5) Acute phase protein (5, 4.4%); and (6) Others (20, 17.7%). Compared with healthy control or recovered patients without long COVID symptoms, 79 biomarkers were increased, 29 were decreased, and 5 required further determination in the long COVID patients. Of these, up-regulated Interleukin 6, C-reactive protein, and tumor necrosis factor alpha might serve as the potential diagnostic biomarkers for long COVID. Moreover, long COVID patients with neurological symptoms exhibited higher levels of neurofilament light chain and glial fibrillary acidic protein whereas those with pulmonary symptoms exhibited a higher level of transforming growth factor beta.ConclusionLong COVID patients present elevated inflammatory biomarkers after initial infection. Our study found significant associations between specific biomarkers and long COVID symptoms. Further investigations are warranted to identify a core set of blood biomarkers that can be used to diagnose and manage long COVID patients in clinical practice.
Case Report: Endoscopic radiofrequency ablation with radial-EBUS and ROSE
Authors: Zarogoulidis Paul , Hohenforst-Schmidt Wolfgang , Papadopoulos Vasileios , Perdikouri Eleni-Isidora , Courcoutsakis Nikolaos , Porpodis Konstantinos , Matthaios Dimitrios , Trigonakis Kostas 
Published: January 2023

BackgroundSingle pulmonary nodules are a common issue in everyday clinical practice. Currently, there are navigation systems with radial-endobronchial ultrasound and electromagnetic navigation for obtaining biopsies. Moreover, rapid on-site evaluation can be used for a quick assessment. These small lesions, even when they do not have any clinically significant information with positron emission tomography, are important to investigate.Case descriptionRadiofrequency and microwave ablation have been evaluated as local treatment techniques. These techniques can be used as therapy for a patient population that cannot be operated on. Currently, one verified operating system is used for endoscopic radiofrequency ablation through the working channel of a bronchoscope.ConclusionIn our case, a new system was used to perform radiofrequency ablation with long-term follow-up.
Understory species composition mediates soil greenhouse gas fluxes by affecting bacterial community diversity in boreal forests
Authors: Duan Beixing , Xiao Ruihan , Cai Tijiu , Man Xiuling , Ge Zhaoxin , Gao Minglei , Mencuccini Maurizio 
Published: January 2023

IntroductionPlant species composition in forest ecosystems can alter soil greenhouse gas (GHG) budgets by affecting soil properties and microbial communities. However, little attention has been paid to the forest types characterized by understory vegetation, especially in boreal forests where understory species contribute significantly to carbon and nitrogen cycling.MethodIn the present study, soil GHG fluxes, soil properties and bacterial community, and soil environmental conditions were investigated among three types of larch forest [Rhododendron simsii-Larix gmelinii forest (RL), Ledum palustre-Larix gmelinii forest (LL), and Sphagnum-Bryum-Ledum palustre-Larix gmelinii forest (SLL)] in the typical boreal region of northeast China to explore whether the forest types characterized by different understory species can affect soil GHG fluxes.ResultsThe results showed that differences in understory species significantly affected soil GHG fluxes, properties, and bacterial composition among types of larch forest. Soil CO2 and N2O fluxes were significantly higher in LL (347.12 mg m−2 h−1 and 20.71 μg m−2 h−1) and RL (335.54 mg m−2 h−1 and 20.73 μg m−2 h−1) than that in SLL (295.58 mg m−2 h−1 and 17.65 μg m−2 h−1), while lower soil CH4 uptake (−21.07 μg m−2 h−1) were found in SLL than in RL (−35.21 μg m−2 h−1) and LL (−35.85 μg m−2 h−1). No significant differences between LL and RL were found in soil CO2, CH4, and N2O fluxes. Soil bacterial composition was mainly dominated by Proteobacteria, Actinobacteria, Acidobacteria, and Chloroflexi among the three types of larch forest, while their abundances differed significantly. Soil environmental variables, soil properties, bacterial composition, and their interactions significantly affected the variations in GHG fluxes with understory species. Specifically, structural equation modeling suggested that soil bacterial composition and temperature had direct close links with variations in soil GHG fluxes among types of larch forest. Moreover, soil NO3−−N and NH4+ − N content also affected soil CO2, CH4, and N2O fluxes indirectly, via their effects on soil bacterial composition.DiscussionOur study highlights the importance of understory species in regulating soil GHG fluxes in boreal forests, which furthers our understanding of the role of boreal forests in sustainable development and climate change mitigation.
Serum uric acid to serum creatinine ratio predicts neurological deterioration in branch atheromatous disease
Authors: Liu Yinglin , Wang Honglei , Xu Ronghua , He Lanying , Wu Kun , Xu Yao , Wang Jian , Xu Fan 
Published: January 2023

Background and objectiveBranch atheromatous disease (BAD) makes patients prone to early neurological deterioration (END), resulting in poor prognosis. The aim of this study was to investigate the association between SUA/SCr and END in BAD stroke patients.MethodsWe conducted a retrospective study that included 241 patients with BAD-stroke within 48 h of symptom onset. We divided the patients into the END group and the no END group. END was defined as an NIHSS score increase of more than 2 points within 1 week. SUA/SCr was calculated by the concentration of serum uric acid and creatine (serum uric acid/serum creatine) on admission. Univariate and multivariate analyses were used to identify independent predictors of END in BAD-stroke patients.ResultsEND was observed in 24.1% (58/241) of the patients in our study. Multiple logistic regression analyses showed that SUA/SCr (aOR, 0.716; 95% CI, 0.538–0.952; P = 0.022) and female sex (aOR, 0.469; 95% CI, 0.245–0.898; P = 0.022) were associated with END after adjusting for confounding factors. The predicted value of SUA/Scr for END was a sensitivity of 79.3%, a specificity of 44.8%, and an AUC of 0.609 (95% CI, 0.527–0.691, P &lt; 0.05). The optimal cut-off value was 4.76.ConclusionSUA/SCr was negatively associated with the risk of END in BAD stroke patients.
Two levels vs. one level of phallopexy in the treatment of concealed penis in patients in pediatric age group
Authors: Elrouby Ahmed , Saad Israa , Kotb Mostafa 
Published: January 2023

IntroductionConcealed penis, which is the congenital type of buried penis, is a condition in which a normal-sized penis is totally or partially hidden by pubic, scrotal, or thigh skin. Several procedures had been described for its correction including phallopexy, that is, fixation of penile Buck's fascia to the sub-dermis.Aim of the workOur work aims to study the difference in outcome between performing phallopexy at one level and at two levels.Material and methodsOur study included 180 uncircumcised patients who had a concealed penis while having an average length of an outstretched penis. These patients were divided into two groups: the first one was treated with one level of phallopexy at the 3 and 9 o'clock points, while the second group was treated with the same procedure in addition to another level of stitches at the mid-penile level. The follow-up was carried out for one post-operative year regarding penile skin edema, infection, congestion, necrosis, and/or re-retraction.ResultsThe overall success rate was 96.1% for a normally-looking penis without post-operative re-retraction. Re-retraction developed in two patients (2.2%) of those who had one-level phallopexy and in five patients (5.6%) of those who had two-level phallopexy without statistical significance (FEp = .444). Penile skin edema developed in 76 patients (42.2%) being significantly lower in patients with lower body weight (p = .030*).ConclusionPhallopexy could be performed safely in the case of the concealed penis with satisfactory results. Two levels of phallopexy did not add any advantage to the post-operative results besides the fact that this may be demanding, time-consuming, and may require higher resources, so we recommend the easier one-level phallopexy in the treatment of such conditions with satisfactory results.
Radial head and neck fractures in children and adolescents
Authors: Kalbitz Miriam , Lackner Ina , Perl Mario , Pressmar Jochen 
Published: January 2023

BackgroundRadial head and neck fractures are a rare entity in pediatric patients. Due to specific characteristics of the blood supply and remodeling potential, the correct diagnosis and initiation of appropriate therapy are crucial for the outcome. Therefore, the aim of this retrospective observational study was to present the outcome of a series of pediatric patients with radial head and neck fractures.MethodsIn total, 67 pediatric and adolescent patients with a fracture of the proximal radius admitted to a Level I Trauma Center (Germany) between 2005 and 2017 were included in this retrospective observational study. Patients were stratified in accordance with the classification of Judet modified by Metaizeau and with the AO Pediatric Comprehensive Classification of Long Bone Fractures (AO-PCCF).ResultsAO-PCCF fracture type of proximal radius was age-dependent. Epiphyseal axis angle and displacement angle correlated significantly. Fractures treated with a K-wire or embrochage centromedullaire elastique stable (ECMES) presented higher displacement angles. The duration of callus formation was dependent on both the reduction technique and fracture displacement. The range of motion after complete fracture consolidation was dependent on the Metaizeau type and reduction technique but independent of the duration of immobilization and physical therapy.Conclusion and clinical relevanceBoth the epiphyseal axis and displacement angle are suitable for measuring the initial fracture displacement in radiographs. Consolidation is dependent on the initial displacement and reduction technique. The mini-open approach leads to a worse reduction result, later callus formation, and a more restricted range of motion in terms of pronation. Furthermore, the range of motion at follow-up is independent of the duration of immobilization and physiotherapy.
Nanomolar clodronate induces adenosine accumulation in the perfused rat mesenteric bed and mesentery-derived endothelial cells
Authors: Donoso M. Verónica , Hernández Felipe , Barra Rafael , Huidobro-Toro J. Pablo 
Published: January 2023

The vesicular nucleotide transporter (VNUT) is critical for sympathetic co-transmission and purinergic transmission maintenance. To examine this proposal, we assessed whether the bisphosphonate clodronate, claimed as a potent in vitro VNUT blocker, modified spontaneous and/or the electrically evoked overflow of ATP/metabolites and NA from mesentery sympathetic perivascular nerve terminals. Additionally, in primary endothelial cell cultures derived from this tissue, we also evaluated whether clodronate interfered with ATP/metabolite cell outflow and metabolism of N6-etheno adenosine 5′-triphosphate (eATP), N6-etheno adenosine (eADO), and adenosine deaminase enzyme activity. Rat mesenteries were perfused in the absence or presence of .01–1,000 nM clodronate, 1–1,000 nM Evans blue (EB), and 1–10 µM DIDS; tissue perfusates were collected to determine ATP/metabolites and NA before, during, and after perivascular electrical nerve terminal depolarization. An amount of 1–1,000 nM clodronate did not modify the time course of ATP or NA overflow elicited by nerve terminal depolarization, and only 10 nM clodronate significantly augmented perfusate adenosine. Electrical nerve terminal stimulation increased tissue perfusion pressure that was significantly reduced only by 10 nM clodronate [90.0 ± 18.6 (n = 8) to 35.0 ± 10.4 (n = 7), p = .0277]. As controls, EB, DIDS, or reserpine treatment reduced the overflow of ATP/metabolites and NA in a concentration-dependent manner elicited by nerve terminal depolarization. Moreover, mechanical stimulation of primary endothelial cell cultures from the rat mesentery added with 10 or 100 nM clodronate increased adenosine in the cell media. eATP was metabolized by endothelial cells to the same extent with and without 1–1,000 nM clodronate, suggesting the bisphosphonate did not interfere with nucleotide ectoenzyme metabolism. In contrast, extracellular eADO remained intact, indicating that this nucleoside is neither metabolized nor transported intracellularly. Furthermore, only 10 nM clodronate inhibited (15.5%) adenosine metabolism to inosine in endothelial cells as well as in a commercial crude adenosine deaminase enzyme preparation (12.7%), and both effects proved the significance (p &lt; .05). Altogether, present data allow inferring that clodronate inhibits adenosine deaminase activity in isolated endothelial cells as in a crude extract preparation, a finding that may account for adenosine accumulation following clodronate mesentery perfusion.
Wavelet analysis of laser Doppler microcirculatory signals: Current applications and limitations
Authors: Kralj Lana , Lenasi Helena 
Published: January 2023

Laser Doppler flowmetry (LDF) has long been considered a gold standard for non-invasive assessment of skin microvascular function. Due to the laser Doppler (LD) microcirculatory signal’s complex biological and physiological context, using spectral analysis is advisable to extract as many of the signal’s properties as feasible. Spectral analysis can be performed using either a classical Fourier transform (FT) technique, which has the disadvantage of not being able to localize a signal in time, or wavelet analysis (WA), which provides both the time and frequency localization of the inspected signal. So far, WA of LD microcirculatory signals has revealed five characteristic frequency intervals, ranging from 0.005 to 2 Hz, each of which being related to a specific physiological influence modulating skin microcirculatory response, providing for a more thorough analysis of the signals measured in healthy and diseased individuals. Even though WA is a valuable tool for analyzing and evaluating LDF-measured microcirculatory signals, limitations remain, resulting in a lack of analytical standardization. As a more accurate assessment of human skin microcirculation may better enhance the prognosis of diseases marked by microvascular dysfunction, searching for improvements to the WA method is crucial from the clinical point of view. Accordingly, we have summarized and discussed WA application and its limitations when evaluating LD microcirculatory signals, and presented insight into possible future improvements. We adopted a novel strategy when presenting the findings of recent studies using WA by focusing on frequency intervals to contrast the findings of the various studies undertaken thus far and highlight their disparities.
AI-based chatbot micro-intervention for parents: Meaningful engagement, learning, and efficacy
Authors: Entenberg Guido A. , Mizrahi Sophie , Walker Hilary , Aghakhani Shirin , Mostovoy Karin , Carre Nicole , Marshall Zendrea , Dosovitsky Gilly , Benfica Daniellee , Rousseau Alexandra , Lin Grace , Bunge Eduardo L. 
Published: January 2023

IntroductionMental health issues have been on the rise among children and adolescents, and digital parenting programs have shown promising outcomes. However, there is limited research on the potential efficacy of utilizing chatbots to promote parental skills. This study aimed to understand whether parents learn from a parenting chatbot micro intervention, to assess the overall efficacy of the intervention, and to explore the user characteristics of the participants, including parental busyness, assumptions about parenting, and qualitative engagement with the chatbot.MethodsA sample of 170 parents with at least one child between 2–11 years old were recruited. A randomized control trial was conducted. Participants in the experimental group accessed a 15-min intervention that taught how to utilize positive attention and praise to promote positive behaviors in their children, while the control group remained on a waiting list.ResultsResults showed that participants engaged with a brief AI-based chatbot intervention and were able to learn effective praising skills. Although scores moved in the expected direction, there were no significant differences by condition in the praising knowledge reported by parents, perceived changes in disruptive behaviors, or parenting self-efficacy, from pre-intervention to 24-hour follow-up.DiscussionThe results provided insight to understand how parents engaged with the chatbot and suggests that, in general, brief, self-guided, digital interventions can promote learning in parents. It is possible that a higher dose of intervention may be needed to obtain a therapeutic change in parents. Further research implications on chatbots for parenting skills are discussed.
Relationships between athletic ability and academic performance in primary school students: A 3-year follow-up study
Authors: Ji Hao Zong , Bai Cui Jin , Yun Yang , Dong Wu Xiang , Yi Qian Ze , Ping Wu Dan , Yi Tang , Xia Zheng Hong , Min Zhang Zhi , Long Xu Jing , Fei Zhang Teng , Ji Wang Jun , Zhen Li , Zhuang Gao , Ke Li Ying 
Published: January 2023

BackgroundThe aim of this study was to examine whether academic performance is associated with students' athletic ability in primary school.MethodsA 3-year follow-up study was conducted among 1,136 Chinese students. Sit-up and jump rope testers were used to measure 1-min sit-ups and 1-min jump ropes, respectively. Meanwhile, the Pittsburgh Sleep Quality Scale and the Beck Depression Inventory were used to estimate sleep quality and depression levels. The end-of-semester examinations were used to evaluate students' academic performance during the follow-up period.ResultsAfter adjusting for confounders, the mean change in Chinese language performance for participants stratified by 1-min sit-ups at baseline was 0.35 (95% CI: −0.37 to 0.76) for level 1 (slowest), 0.52 (95% CI: −0.54 to 1.08) for level 2, and 1.72 (95% CI: 1.14 to 2.30) for level 3 (fastest) (P for trend = 0.003); the mean change in math scores was 0.28 (95% CI: −0.50 to 0.95) for level 1 (slowest), 0.95 (95% CI: 0.38 to 1.52) for level 2, and 1.41 (95% CI: 0.82 to 1.99) for level 3 (fastest) (P for trend = 0.048). The mean change in foreign language scores was −0.45 (95% CI: −0.99 to −0.93) for level 1 (slowest), −0.14 (95% CI: −0.44 to 0.41) for level 2, and 0.69 (95% CI: 0.25 to 1.13) for level 3 (fastest) (P for trend = 0.004). The mean change in Chinese language performance for participants stratified by 1-min jump ropes at the baseline was 0.30 (95% CI: −0.16 to 0.76) for level 1 (slowest), 1.09 (95% CI: 0.42 to 1.76) for level 2, and 1.74 (95% CI: 1.14 to 2.35) for level 3 (fastest) (P for trend = 0.001). The mean change in math scores was 0.41 (95% CI: −0.11 to 0.92) for level 1 (slowest), 1.44 (95% CI: 0.69 to 2.19) for level 2, and 1.43 (95% CI: 0.76 to 2.10) for level 3 (fastest) (P for trend = 0.019). The mean change in foreign language performance was −0.71 (95% CI: −1.08 to −0.33) for level 1 (slowest), 0.95 (95% CI: −0.40 to 1.50) for level 2, and 0.91 (95% CI: 0.41 to 1.41) for level 3 (fastest) (P for trend &lt; 0.001).ConclusionThis study suggests that participation in jump rope and sit-up exercises may positively affect students' academic performance.
Effects of chronic stress on smartphone addiction: A moderated mediation model
Authors: Qiu Huake , Lu Hongliang , Pei Jiawei , Zhang Yajuan , Ma Yongjie , Xing Chen , Wang Xinlu , Zhu Xia 
Published: January 2023

IntroductionBased on the compensatory Internet use theory and diathesis-stress model, the present study explores the effects of chronic stress on smartphone addiction (SPA). As intolerance of uncertainty and emotion-related variables are important factors that affect addictive behavior, we explore the mediating role of intolerance of uncertainty and the moderating role of emotion differentiation.MethodsWe conducted a questionnaire survey of 286 participants (13.64% female; Mage = 22.88; SD = 3.77; range = 17–39) on chronic stress, SPA, intolerance of uncertainty, and emotion differentiation. SPSS 28.0 was used to analyze the descriptive statistics and correlations and test the moderated mediation model.ResultsWe find that (1) intolerance of uncertainty, SPA, and chronic stress are positively correlated with each other. Positive emotion differentiation is positively correlated with intolerance of uncertainty and negative emotion differentiation. (2) Intolerance of uncertainty plays a mediating role in chronic stress and SPA. (3) Positive emotion differentiation significantly moderates the relationship between chronic stress and SPA. Under the condition of low positive emotion differentiation, chronic stress is more effective in predicting SPA.DiscussionThese findings may contribute to intervention and prevention programs for SPA. Thus, the intervention and prevention of SPA can start from two directions-reduce the intolerance of uncertainty and enhance the ability to experience positive emotion differentiation.