bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasonography combined with endoscopic ultrasound-guided fine-needle aspiration to diagnosis of primary pancreatic lymphoma: a case report
Authors: Zhang Jie , Wen Hua , Du Zhaozhao , Fan Ling , Li Jie , Lu Ning , Cui Manli , Zhang Mingxin 
Published: December 2022

Abstract
Background
Primary pancreatic lymphoma (PPL) is an extremely rare disease with relatively non-specific clinical symptoms.It is easily overlooked and even misdiagnosed as pancreatic cancer.Clinically, we can rely on ultrasound or CT-guided aspiration for histopathological examination.These can avoid unnecessary dissection procedures and complications and reduce the lethality of lymphoma.
Case presentation
A 79-year-old woman was admitted to the hospital with "abdominal pain with cough for 1 month and worsening abdominal distension for 2 weeks".Abdominal CT/MRI: irregular soft tissue mass in the caudal region of the pancreatic body, multiple enlarged lymph nodes in the abdominal cavity and retroperitoneum, partially fused in the form of masses, metastasis was considered. Ultrasonography results: pancreatic cancer.Pathology of the abdominal mass puncture was suggestive of aggressive B-cell lymphoma.After pathological confirmation on November 20, 2021, she was transferred to the hematology department for chemotherapy with CHOP, CHOPE, and R-ESHAP regimens.She was stabilized after chemotherapy and then progressed and died in October 2022.
Conclusions
The diagnosis of PPL requires a multidisciplinary treatment model,full communication and in-depth discussion with all auxiliary and clinical departments to solve difficult problems, improve the level of treatment, promote individualized and standardized treatment of lymphoma, achieve early diagnosis and treatment, and thus reduce the mortality of lymphoma.
WITHDRAWN: Temporal Transcriptome Highlights the Involvement of Cytokine/JAK/STAT3 Signaling Pathway in the Osteoinduction of BMSCs
Authors: Ru Xiao , Cai Peian , Jin Pan , Zhong Qiuling , Huang Yuanjun , Tan Manli , Zheng Li , Lu Zhenhui 
Published: December 2022

Abstract
Background: Mesenchymal stem cells (MSCs)-based therapy offers an effective strategy for bone regeneration to solve the clinical orthopedic problems. However, the transcriptional regulation of multiple transitional stages of osteogenesis from MSCs has not been fully characterized.
Methods and Results: Bone marrow mesenchymal stem cells (BMSCs) stimulated with osteogenic induction media were utilized to construct the in vitro osteogenic differentiation model. BMSCs were harvested after induction for 0, 7, 14 and 21 days, respectively, to perform the mRNA-sequencing (mRNA-Seq). The transcription factor networks and common molecules during the osteogenesis were revealed by using the temporal transcriptome. Further verification was performed by the quantitative real time polymerase chain reaction (qRT-PCR) and immunofluorescence. It showed that BMSCs could differentiate into osteogenic, and crucial regulator in Cytokine/JAK/STAT3 signaling pathway including leukemia inhibitory factor (LIF), interleukin-6 (IL6)and colony stimulating factor 3 (CSF3) that modulate the phosphorylation of STAT3 were positivity associated with osteogenesis and angiogenesis.
Conclusions: Our work might provide new insights in the crucial features of the transcriptional regulation during the osteogenesis, as well as offer important clues about the activity and regulation of Cytokine/JAK/STAT3 signaling pathway in osteoinduction of MSCs.
Virtual Screening on Protein-Ligand Interactions: A pharmacological Aspect of Zingiber officinale for COVID-19 remedy
Authors: Gurisha Mikidadi S. , Jackson Alex , Rao P. V. Kanaka 
Published: December 2022

Abstract
With the current pandemic of the novel coronavirus disease 2019(COVID-19) in hand, researchers around the world are dexterously working to find the best suitable drug candidates and to overcome vaccination-related challenges. In Tanzania, ginger (Zingiber officinale) has been taken as a traditional remedy for COVID-19 by processing it into a different drinks. Computer-aided drug discovery provides a promising attempt to allow scientists to develop new and target-specific drugs to fight any disease. Therefore, in this study, Virtual Screening was conducted on 113 phytochemicals derived from the Zingiber officinale herb to find lead molecules for SARS-CoV-2. A total of 10 phytochemicals qualified from PyRx Virtual Screening, out of which only 5 demonstrated a substantial binding affinity with D614G SARS-CoV-2 protein, compared to remdesivir which is so far recommended by the FDA in the treatment of COVID-19. Molecular docking analysis was conducted using BIOVIA Discovery Studio, where 7BNO Open conformation of D614G SARS-CoV-2 was used as the protein receptor. The results shows that, Gingerenone A have greater binding affinity of -7.6, followed by Jyperin − 7.0, Meletin − 6.9, Isorhamnetin − 6.8 and Shogaol − 5.9. The binding affinity of remdesivir (-6.8) is less than binding affinity of Gingerenone A by 1%. These results are signifying that these phytochemicals can be used in drugs development. On the other hand, binding affinity for some of Zingiber Officinale phytochemicals derived from this study were compared with those from other studies conducted using similar approach. Equally, all selected phytochemicals demonstrated compliances with Lipinski's Rule of Five. Therefore, the present study identifies potential inhibitors of D614G SARS-CoV-2 protein for COVID 19 which needs to be validated further, both experimentally and clinically.
A Cascaded Convolutional Neural Network for Image Deblurring and Denoising
Authors: M Mahendra B , Sonoli Savita , Gowda Tarun 
Published: December 2022

Abstract
Although noise management has received a lot ofattention recently, image deblurring is still difficult. Imageswithout any noisy pixels are the focus of the current deblurringnetworks. To explicitly or implicitly lessen the impact of noisypixels on image deblurring, existing methods primarily relyon repetitive noise detection stages. However, these iterativeoptimization procedures and heuristic operations, which aredifficult and time-consuming, are frequently used in these noisypixels detection steps. In this paper we propose a cascaded modelof two separate networks which will handle the noisy pixelswithout any reduction in image quality. Our model aims todenoise an image first and then deblur it. In addition, it wasfound that deblurring an image first, then denoising it, producedbetter results than training a deblurring network on noisy images.Numerous tests demonstrate that this cascaded network performscompetitively in terms of PSNR and SSIM.
Mapping the research trend of PCOS: from 2006 to 2022
Authors: Zhu Jiani 
Published: December 2022

AbstractBackground: Multi-field specialists are required to assist in treatment. The large amount of literature on PCOS and its complex mechanism are difficult to sort out by reading the literature alone, thus we conduct a bibliometric study on PCOS, aiming to clarify the current research results of PCOS and predict the future research hotspots.Objectives: Our research aims to map the research trend of PCOS from 2006 to 2022, and help readers quickly understand its research history and future development trend.Methods: Literatures published from January 1, 2006 to June 30, 2022 were retrieved in the PubMed database, and devided into 4 periods. Of each peroid, major mesh terms/subheadings were extracted and used to conduct co-occurrence matrices and term-article matrices by Bibliographic Item Co-Occurrence Matrix Builder (BICOMB) software. The gCLUTO software was used to bicluster the term-article matrix. Social network analysis was conducted based on the word co-occurrence matrix by Gephi software.Results: From 2006 to 2010, research mainly focused on the infertility etiology and therapy of PCOS. In next period, from 2011 to 2015, research hotspots shifted to infertility drug therapy of PCOS and obesity and infertility of PCOS. After that, from 2016 to 2019, the relationship between insulin resistance and blood hormones, obesity and infertility, PCOS genetics and metabolism has attracted people's attention. In recent two years, the research of cardiovascular diseases and PCOS has become a hot topic, and epigenetics of PCOS has attracted extensive attention.Conclusions:This study well describes the research and development process of PCOS in the past 16 years, as well as the research hotspots and trends in the future.
Feasibility of 1 H MR spectroscopy in malignant pulmonary lesions at 3 Tesla: phantom study and clinical verification
Authors: Ebrahimi Marzieh , Bitarafan-Rajabi Ahmad , Paymani Zeinab , Kooranifar Siavash , Zare-Sadeghi Arash , Fard-Esfahani Armaghan , Raminfard Samira , Rohringer Taryn J 
Published: December 2022

Abstract
Purpose:
Primary lung malignancies are the leading cause of cancer death worldwide. In addition to primary lung malignancy, the presence of pulmonary metastases has a critical role in patient prognostication and management. Recently, cellular and molecular imaging, particularly proton magnetic resonance spectroscopy (1H MRS), has been employed for early tumor detection. This article aims to survey the role of 1H-MRS as a virtual biopsy technique to determine the biological make-up of lung lesions.
Methods:
NEMA IEC phantom analysis was utilized to acquire free induction decay (FID) of several tumor markers including choline, lactate, and creatine on single-voxel spectroscopy (SVS) at 3 Tesla (T) MRI. Various protocol modifications were performed on acquisition and processing steps. Preliminary in vivo verifications were subsequently performed on MRS datasets of 4 patients with malignant lung pathologies.
Results:
1H MRS of phantom revealed detectable peaks of choline, lactate and creatine in concentrations above the threshold of 1 µ Molar (µM) in patients with lung malignancies. Our result demonstrate that the phantom sphere diameter is the most influential factor on peak detectability with minimum reasonable value of 13mm; with the least acceptable in vitro voxel size of 1 cm3 and in vivo equivalent of 8 cm3. Trading off between acquisition time and signal to noise ratio (SNR), the appreciable number of acquisition (NAS) was equal to 64. A quantitative formula was derived to calculate metabolite concentrations (AUC=0.73). Concordant results were obtained on pilot clinical assessments.
Conclusion:
This preliminary study provides a one-stop-shop solution for SVS through optimizing acquisition and processing parameters as well as absolute quantification of choline, lactate, and creatine concentrations in malignant pulmonary lesions, with successful clinical verification.
Symptomatology and Quality of Life After Rubber Band Ligation for Haemorrhoidal Disease
Authors: Peinado Paula Pastor , Ocaña Juan , Barnó Pedro Abadía , Pérez Araceli Ballestero , Hernández Juan Diego Pina , Velasco Gloria Rodríguez , Montes Irene Moreno , Conde Elena Mendía , de Blas Estela Tobaruela , Cebrián José María Fernández , Trill Javier Die , Pérez Juan Carlos García 
Published: December 2022

Abstract

Purpose
The main objective of this study was to assess the impact on quality of life after rubber band ligation (RBL) in patients with symptomatic grade II-III haemorrhoids who did not improve after 6 months of conservative treatment, using quality of life scores.
Methods
This was a prospective cohort observational study where patients with haemorrhoidal disease and indication for RBL were included between December 2019 and December 2020. Patient´s quality of life was assessed by scores: HDSS (Hemorrhoidal Disease Symptom Score) and SHS (Short Health Scale), obtained by personal interview and telephone calls. Secondary objectives were: to evaluate the rate of patients requiring one or more RBL procedures, to establish the overall success rate of RBL and to analyse complications.
Results
A total of 100 patients were finally included. Regarding the impact on quality of life after RBL, a significant reduction was found in the HDSS and SHS scores (p<0.001). The main improvement was found in the first month and it was maintained until the sixth month. A high degree of satisfaction with the procedure was reported by 76% of patients. The overall success rate of banding was 89% at 18 months. A 12% complication rate was detected, the most frequent complication was severe anal pain (58.3%) and self-limiting bleeding (41.7%).
Conclusion
Hemorrhoidal RBL as a treatment for symptomatic grade II-III haemorrhoids that do not respond to medical treatment leads to a significant improvement in patients' symptoms and quality of life. It also has a high degree of satisfaction between patients.
Cascading use of renewable growing media versus peat or mineral wool: added value of biochar for end-of-life, recycling of nutrients and C storage potential
Authors: Vandecasteele Bart , Similon Lotte , Moelants Julie , Hofkens Maarten , Melis Peter , Visser Rianne 
Published: December 2022

Abstract

The composition of horticultural substrates for soilless greenhouse cultivation directly affects the sustainability of the cropping system but has also an indirect effect through the end-of-life of the spent media. Biochar amendment in growing media as bulk material and source of nutrients may improve the sustainability of controlled-environment agriculture. Horticultural substrates at the end of soilless strawberry and tomato cultivation were compared in 6 trials at commercial scale. Conventional mineral wool and peat-based blends were compared with peat-reduced and peat-free organic blends with or without 10 vol% biochar. Nutrients, C stability of the growing media and their value as soil improver were measured. The organic growing media had a high potential for reuse and for C storage. Spent mineral wool was significantly richer in total P, K, Mg and Ca and significantly lower in organic C content and C stability than the other blends, with a clearly lower value as soil improver than the organic blends. Biochar amendment in renewable organic blends increases its value as soil improver and the potential for reuse: adding 10 vol% biochar in the blend significantly increased the C content by 8% and the C:N ratio of the spent growing media but not the C stability. The pH of the biochar in the growing media decreased from 9.1 to 6.2 due the cultivation while the CEC increased. This research illustrates the feasibility of using biomass and biochar in cascade, i.e., first as growing medium, and finally as a C-rich soil improver.
The power law relationship between the semi-major axis and the product of the mass ratio and the square of the rotation period ratio in an eccentric system, its role and the physical mechanism of its formation
Authors: Dai Yongfeng 
Published: December 2022

Abstract
This study introduces the concepts of mass ratio order of magnitude and synchronous orbit radius ratio, and investigates the relationship between semi-major axis and synchronous orbit radius ratio in known systems with the same level of mass ratio order of magnitude, the same level of spin-orbit angle, and eccentric/circular orbits, including binaries, star-planet systems and planet-moon systems. Results show that in a system with an eccentric orbit (e>0.01) and a mass ratio order of magnitude greater than –7.5217, the semi-major axis has a power-law distribution relationship with the product of the mass ratio and the square of the rotation period ratio, and under conditions of spin-orbit alignment, the power-law exponent has a positive linear relationship with the mass ratio order of magnitude and is greater than 0 and less than or equal to 1. Meanwhile, this study also concludes that this power law relationship plays a decisive role in the formation of eccentric orbits. Based on Einstein’s equivalence principle and Newton’s law of gravity, this study also proposes that a moving gravitational field may exert a drag force on a mass body in the moving direction, and reveals the physical mechanism of the formation of this power law relationship. Based on such a mechanism, this study proposes that for a spin-orbit misaligned system, its power-law exponent is close to the product of the power-law exponent under conditions of spin-orbit alignment and the cosine of the spin-orbit angle.
Associations of HLA polymorphisms with anti-SARS-CoV-2 spike and neutralizing antibody titers in Japanese rheumatoid arthritis patients vaccinated with BNT162b2
Authors: Higuchi Takashi , Oka Shomi , Furukawa Hiroshi , Tohma Shigeto 
Published: December 2022

Abstract
Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019. Anti-SARS-CoV-2 spike (S) and neutralizing antibodies (Abs) are measured to evaluate the efficacy of vaccines. Human leukocyte antigen (HLA) may be associated with vaccine efficacy. Here, we investigated the association of HLApolymorphisms with the production of anti-SARS-CoV-2 S or neutralizing Abs in vaccinated rheumatoid arthritis (RA) patients in Japan.
Methods: Genotyping of DRB1and DQB1 was conducted in 87 Japanese RA patients vaccinated with BNT162b2. Associations of allele or haplotype carrier frequencies with anti-SARS-CoV-2 S or neutralizing Abs were examined.
Results: DRB1*12:01 was significantly positively associated with the production of S Ab (P= 0.0225, odds ratio [OR] 6.08, 95% confidence interval [CI] 1.32-28.03). The DQB1*03:01 allele carrier frequency tended to be higher in high responders of S Ab. Allele carrier frequencies of DRB1*15:01 (P= 0.0102, OR 9.26, 95% CI 1.65-52.01) and DQB1*06:02(P=0.0373, OR 7.00, 95%CI 1.18-41.36) were higher in responders of neutralizing Ab. Haplotype and two-locus analyses of DRB1 and DQB1 suggested that DRB1 alleles were the primary drivers of these associations. Logistic regression analysis showed associations of these alleles independent of clinical characteristics.
Conclusion: Independent associations were found between HLA alleles and anti-SARS-CoV-2 Ab production by vaccinated RA patients.
A Patient with Newly Diagnosed Hypertension and Pre-Existing Type 2 Diabetes Mellitus Had a Confirmed COVID-19: A Case Report and Discussion
Authors: Bereda Gudisa 
Published: December 2022

Abstract
COVID-19 aggravates pre-existing diabetes mellitus and contributes to newly discovered hypertension by increasing blood pressure by inhibiting the activity of angiotensin-converting enzymes 2 in the rennin-angiotensin system. Diabetes patients may be more vulnerable to COVID-19 due to chronic comorbidities such as obesity and cardiovascular disease such as hypertension. On March 23, 2022, a retired black African woman in her sixties was taken into the emergency room with the chief complaints of frequent midnight urine, hazy vision, headache, fever, and tingling in her hands and feet. A throat swab polymerase chain reaction test that revealed positive results after 28 hours was used to confirm COVID-19. Her electrocardiogram showed sinus tachycardia with a heart rate of 105 beats per minute. Fluid resuscitation (0.9% normal saline) of 1000 mL and drip insulin administration were commenced as soon as she was brought to an intensive care unit. In this case report, the patient had been previously diagnosed with type 2 diabetes mellitus. COVID-19 affects the beta cells, forcing them to release insulin and increasing the insulin insufficiency, which leads to her blood glucose raising. Type 2 diabetes mellitus is therefore the most frequent comorbidity of COVID-19 in this case report. Poor blood glucose management in the case of COVID-19 may increase the pathogen's susceptibility, the likelihood that patients will be admitted to the hospital, and the likelihood that mortality will be enhanced.
Custom Hardware and Software Integration: Bluetooth Based Wireless Thermal Printer for Restaurant and Hospital Management
Authors: Viswanatha V , A.C Ramachandra , M Sathish B , P Ashwini Kumari , R Venkata Siva Reddy , R Srinivasa Murthy 
Published: December 2022

Abstract
In this paper, the communication between Arduino Mega microcontroller and mini thermal printer is implemented by hardware and software integration. The microcontroller is programmed to transfer the data from microcontroller to printer using a serial communication protocol such as universal asynchronous receiver and transmitter (UART) via Serial communication devices such as MAX232 converter, DB9 connector which is nothing but RS232 serial port, and universal serial bus (USB) communication port. Data sent by the microcontroller is made to print from the printer and it is shown in the result section. Digital pins '3' and '4' on the microcontroller are used as virtual Rx and Tx serial lines while leaving the main serial port open for debugging purposes. Interfacing between UART of microcontroller, MAX232, serial port, and the USB port of printer are well established with the complete schematic diagram. The mini thermal printer prints whatever is sent by the microcontroller. A simple code similar to the one used for the serial monitor works for the printer. The baud rate needs to be set at 9600 for the microcontroller to communicate with the printer. The system is designed to print data wirelessly using Bluetooth HC-05 for restaurant and hospital management applications. The system has high adaptability. It can be used in many situations not only for restaurant and hospital management.
Criminal responsibility for illegal intervention in the work of court’s automatical flow of documents: analysis of the basic elements of crime
Authors: В. А. Козак  
Published: December 2022

The article analyses objective and subjective sights of criminal’s structure, foreknowleged by part 1 art. 376 cc (illegal intervention in the work of court’s automatical system of flow of documents) formulated relative propositions according improvement of criminal low of Ukraine.
Development of the Legal Regulation of Punishment in the Form of Fine According to the Criminal Code of Ukraine of 2001
Authors: Gornostay Alesia 
Published: December 2022

This topic is relevant because in practice the application of such punishment as a fine is very common, and it has many problematic aspects of the purpose. The purpose of the article is the genesis of the criminal law regulation of punishment in the form of a fine in the current Criminal Code of Ukraine and the analysis of the changes that have taken place over the past 20 years. To achieve this goal, the author used dialectical, historical and comparative methods. These methods helped to investigate the processes of formation and development of the institution of the fine in the Criminal Code of Ukraine of 2001. In the article, the author analyzes the norms of the criminal legislation of Ukraine, which regulate the concept of a fine and the order of its calculation, the maximum and minimum size of the fine. The author emphasizes that the prevalence of the fine in legislation and judicial practice, the methods of its calculation, its size, the grounds and conditions of its application are not constant and are conditioned by socio-economic, political, criminological and legal factors of specific historical periods. This is especially relevant for Ukraine. Current criminal law establishes a fine as the mildest type of punishment among other types of punishment, but this is a controversial provision. The author emphasizes that the legislator hopes for a fine as an effective form of punishment for persons who have committed certain criminal offenses, primarily corruption and against property. At the same time, it was emphasized that regular changes in the rules on fines, especially regarding the size of this type of punishment, are not without significant drawbacks. In this work, they are outlined. Certain positions regarding their elimination have been expressed. Possible options for reforming regulatory provisions are proposed.