bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with non-initiation of osteoporosis pharmacotherapy after hip fracture: analysis of claims data in Japan
Authors: Fujii Tomoko , Mori Takahiro , Komiyama Jun , Kuroda Naoaki , Tamiya Nanako 
Published: July 2023

Abstract

Summary

In an analysis of claims data from a city in Japan, male patients and patients with dementia were less likely to receive osteoporosis pharmacotherapy after hip fracture. Treatment initiation rate has improved between 2014 and 2017.

Purpose
Older adults with recent hip fractures are at a high risk of recurrent fractures. However, the post-fracture care gap has been reported globally. This study examines factors associated with pharmacotherapy non-initiation within 1 year after hip surgery.

Methods
Using medical and long-term care (LTC) claims, and LTC needs certification data in Tsukuba City, Japan, we identified individuals aged 65 years or older who had hip fractures with subsequent surgical procedures between October 1, 2014, and December 31, 2017. Patient (age, sex, dementia, and comorbidities) and health service–related characteristics (fiscal year, type of hospital, number of hospital beds, and admission to recovery phase rehabilitation wards) were examined. The association of these factors with non-pharmacotherapy for osteoporosis within 1 year after hip fracture using multivariable logistic models was analyzed.

Results
We identified 275 patients with hip fractures who did not receive pharmacotherapy pre-fracture. Forty percent of them received pharmacotherapy within 1 year of post-fracture. Male sex (odds ratio (OR) = 4.49 [2.14–9.44]) and dementia (OR = 1.90 [1.03–3.52]) were associated with no pharmacotherapy, whereas later fiscal year (OR = 0.64 [0.48–0.87]) and admission to rehabilitation wards (OR = 0.25 [0.14–0.46]) were associated with pharmacotherapy initiation within 1 year of post-fracture. Comorbidities were not associated with the initiation of pharmacotherapy.

Conclusion
Pharmacotherapy for osteoporosis was less likely to be initiated after a hip fracture in male patients and patients with dementia. These patients should be considered for pharmacotherapy because they are at high risk of recurrent fractures.
Gravity assist space pruning and global optimization of spacecraft trajectories for solar system boundary exploration
Authors: Song Yuqi , Wu Weiren , Hu Hang , Lin Mingpei , Wang Hui , Zhang Jinxiu 
Published: July 2023

AbstractThe solar system boundary exploration mission has the characteristics of long flight time, high fuel consumption, complex gravity-assist sequence and strict constraints. Therefore, the number of decision variables and the search space of the transfer trajectory are very large, resulting in poor convergence and efficiency of the global search of the metaheuristic algorithm. Moreover, the existing gravity assist space pruning algorithm is no longer applicable for solar system boundary exploration. To effectively reduce the search space and improve the effect of trajectory optimization, an improved gravity assist space pruning algorithm is proposed. In this algorithm, a unique pruning procedure is used to effectively prune the search space, a shape of solution space box bounds combining rectangle and rhombus is adopted, and a method to automatically determine the solution space box bounds is presented. To verify the effectiveness of the improved gravity assist space pruning algorithm, the sensitivity of pruning effect to parameters is analyzed and the optimization effects of three typical metaheuristics are compared. The optimization results of 50 repeated runs of the differential evolution algorithm in the entire search space and the solution space box bounds are compared. Simulation results show that the performance of differential evolution algorithm is better than bat algorithm and firefly algorithm. And the improved pruning algorithm can increase the efficiency of subsequent optimization by more than eleven times and the convergence probability of the objective function by fifty of times. The applicability and efficiency of the proposed method for the solar system boundary exploration are demonstrated.
Trends in Routine Checkup Within the Past Year Following a Hurricane
Authors: Stimpson Jim P. , Lopez Mercado Damaris , Rivera-González Alexandra C. , Ortega Alexander N. 
Published: July 2023

Abstract
The goal of this nationally representative, cross-sectional study is to evaluate the trends in routine checkup within the last year associated with exposure to a hurricane. We compared Puerto Rico (2017 Hurricane Irma, Hurricane Maria), Texas (2017 Hurricane Harvey), and Florida (2017 Hurricane Irma, Hurricane 2018 Michael) with states that had a category 1-2 hurricane make landfall from 2014 to 2019: Georgia, Louisiana, Mississippi, North Carolina, and South Carolina. We found that states impacted by a major hurricane in 2017 had a drop in routine checkup while the states that experienced a category 1-2 landfall did have a change in that year. By the following year, all states reported an increase in routine checkup suggesting that the disruption in routine care was temporary.
Synaptic transistor with multiple biological functions based on metal-organic frameworks combined with the LIF model of a spiking neural network to recognize temporal information
Authors: Wang Qinan , Zhao Chun , Sun Yi , Xu Rongxuan , Li Chenran , Wang Chengbo , Liu Wen , Gu Jiangmin , Shi Yingli , Yang Li , Tu Xin , Gao Hao , Wen Zhen 
Published: July 2023

AbstractSpiking neural networks (SNNs) have immense potential due to their utilization of synaptic plasticity and ability to take advantage of temporal correlation and low power consumption. The leaky integration and firing (LIF) model and spike-timing-dependent plasticity (STDP) are the fundamental components of SNNs. Here, a neural device is first demonstrated by zeolitic imidazolate frameworks (ZIFs) as an essential part of the synaptic transistor to simulate SNNs. Significantly, three kinds of typical functions between neurons, the memory function achieved through the hippocampus, synaptic weight regulation and membrane potential triggered by ion migration, are effectively described through short-term memory/long-term memory (STM/LTM), long-term depression/long-term potentiation (LTD/LTP) and LIF, respectively. Furthermore, the update rule of iteration weight in the backpropagation based on the time interval between presynaptic and postsynaptic pulses is extracted and fitted from the STDP. In addition, the postsynaptic currents of the channel directly connect to the very large scale integration (VLSI) implementation of the LIF mode that can convert high-frequency information into spare pulses based on the threshold of membrane potential. The leaky integrator block, firing/detector block and frequency adaptation block instantaneously release the accumulated voltage to form pulses. Finally, we recode the steady-state visual evoked potentials (SSVEPs) belonging to the electroencephalogram (EEG) with filter characteristics of LIF. SNNs deeply fused by synaptic transistors are designed to recognize the 40 different frequencies of EEG and improve accuracy to 95.1%. This work represents an advanced contribution to brain-like chips and promotes the systematization and diversification of artificial intelligence.
Growth exponents reflect evolutionary processes and treatment response in brain metastases
Authors: Ocaña-Tienda Beatriz , Pérez-Beteta Julián , Jiménez-Sánchez Juan , Molina-García David , Ortiz de Mendivil Ana , Asenjo Beatriz , Albillo David , Pérez-Romasanta Luis A. , Valiente Manuel , Zhu Lucía , García-Gómez Pedro , González-Del Portillo Elisabet , Llorente Manuel , Carballo Natalia , Arana Estanislao , Pérez-García Víctor M. 
Published: July 2023

AbstractTumor growth is the result of the interplay of complex biological processes in huge numbers of individual cells living in changing environments. Effective simple mathematical laws have been shown to describe tumor growth in vitro, or simple animal models with bounded-growth dynamics accurately. However, results for the growth of human cancers in patients are scarce. Our study mined a large dataset of 1133 brain metastases (BMs) with longitudinal imaging follow-up to find growth laws for untreated BMs and recurrent treated BMs. Untreated BMs showed high growth exponents, most likely related to the underlying evolutionary dynamics, with experimental tumors in mice resembling accurately the disease. Recurrent BMs growth exponents were smaller, most probably due to a reduction in tumor heterogeneity after treatment, which may limit the tumor evolutionary capabilities. In silico simulations using a stochastic discrete mesoscopic model with basic evolutionary dynamics led to results in line with the observed data.
Rationalizing mineral gypsum use through microbially enriched municipal solid waste compost for amelioration and regaining productivity potential of degraded alkali soils
Authors: Singh Yash Pal , Arora Sanjay , Mishra Vinay Kumar , Singh Atul Kumar 
Published: July 2023

AbstractReclamation of alkali soils to harness their productivity potential is more complex due to the presence of excess sodium ions, poor hydraulic conductivity and infiltration rate, resulting in poor plant growth and crop productivity. Sodic soil reclamation using inorganic ameliorants like mineral gypsum or phosphogypsum is beyond the reach of small and marginal farmers having alkali soils because of their higher market prices and shortage of availability. Conjoint use of inorganic and organic amendments can be a pragmatic solution for improving soil physico-chemical and biological properties and sustaining crop productivity. Municipal solid waste compost (MSWC) available in abundant quantity if enriched with the efficient halophilic microbial consortium and used in conjunction with a reduced dose of gypsum can be a cost-effective approach for sustainable reclamation of alkali soils and harnessing their productivity potential. Hence, a field experiment was conducted on a high alkali soil (pH29.2 ± 0.10), electrical conductivity (EC) 1.14 ±  0.12﻿ dS m−1, exchangeable sodium percentage 48 ± 2.50 and organic carbon (0.30%) was conducted during 2018–19 to 2020–21 to study the combined effect inorganic and organic (enriched municipal solid waste compost (EMSWC)) amendments on amelioration of alkali soils and sustaining productivity of rice–wheat cropping system. Application of gypsum @ 25% GR + enriched MSW compost @ 10 t ha−1(T6) showed significant improvement in soil physico-chemical and biological properties over the sole application of organic (T3and T4), inorganic (T2) and control (T1). A significant improvement in soil fertility status in terms of available nitrogen and micronutrients as well as CO3,HCO3, Cl, Ca and Mg content were recorded with the combined application of organic and inorganic soil amendments (T5and T6) over the sole application of mineral gypsum. Soil microbial biomass carbon (MBC), nitrogen (MBN) and phosphorus (MBP) improved significantly due to the application of EMSWC with gypsum over the application of gypsum only. Grain yield of rice and wheat increased significantly (P < 0.05) owing to the application of a reduced dose of gypsum (25% GR) and EMSWC @ 10 t ha−1(T6) with values of 5.55 and 3.83 t ha−1, respectively over rest of the treatments. Three years economic analysis of the study revealed that treatments T6and T5gave the highest positive net return whereas it was lowest in treatment T1and negative in treatment T2. The highest benefit-to-cost ratio (B:C) was obtained in treatments T6and T5which were significantly higher compared to the rest of the treatments.
Effect of aerobic and resistance exercise training on endothelial function in individuals with overweight and obesity: a systematic review with meta-analysis of randomized clinical trials
Authors: Cortes Maiquel Bueno , da Silva Raphael Silveira Nunes , de Oliveira Patrícia Caetano , da Silva Diego Silveira , Irigoyen Maria Claudia Costa , Waclawovsky Gustavo , Schaun Maximiliano Isoppo 
Published: July 2023

AbstractThe objective of this systematic review was to examine the effects of exercise training on endothelial function in individuals with overweight and obesity. Our review study included only randomized controlled trials (RCTs) involving adults (≥ 18 years of age) with body mass index (BMI) ≥ 25.0 kg/m2. Our search was conducted in the electronic bases MEDLINE (PubMed), Cochrane, LILACS and EMBASE and in the gray literature. We performed random-effects analyses for effect estimates and used 95% prediction intervals (95% PI) for estimating the uncertainty of the study results. There were selected 10 RCTs involving 14 groups (n = 400). The quality assessment of studies using Cochrane risk-of-bias 2 (RoB 2) tool identified some concerns. Exercise training resulted in improved flow-mediated dilation (FMD) in individuals with overweight and obesity (p < 0.001) compared to the no-exercise control group. This effect of training modalities on FMD was seen for aerobic training (p < 0.001) but not for resistance training (p = 0.051). There was no difference in FMD in response to exercise training by BMI classification (overweight, obesity, overweight + obesity), p = 0.793. The present results are consistent with the notion that aerobic exercise training elicits favorable adaptations in endothelial function in individuals with overweight and obesity. Our findings should be interpreted with caution because of the small number of studies included in this review.
Preclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment
Authors: Allen Derek , Hanumantharao Samerender Nagam , McDonell Rylie , Irvine Karen-Amanda , Sahbaie Peyman , Clark David , Blum Paul 
Published: July 2023

AbstractInhibition of actin remodeling in nerves modulates action potential propagation and therefore could be used to treat acute pain. N-001 is a novel protein analgesic engineered from several C. Botulinum toxins. N-001 targets sensory neurons through ganglioside GT1b binding and ADP-ribosylates G-actin reducing actin remodeling. The activity and efficacy of N-001 was evaluated previously in vitro and in a mouse inflammatory pain model. To assess the relevance of N-001 for treatment of acute post-surgical pain, the current study evaluated the efficacy of N-001 in a mouse hind-paw incision model by peri-incisional and popliteal nerve block administration combined with mechanical testing. N-001 provided relief of pain-like behavior over 3 days and 2 days longer than the conventional long-acting anesthetic bupivacaine. Preclinical safety studies of N-001 indicated the drug produced no toxic or adverse immunological reactions over multiple doses in mice. These results combined with past targeting results encourage further investigation of N-001 as an analgesic for post-operative pain management with the potential to function as a differential nociceptor-specific nerve block.
General teleparallel gravity from Finsler geometry
Authors: Tong Yeheng 
Published: July 2023

Abstract
Riemannian geometry, as a basis for general relativity, can be obtained from the more general Finsler geometry in terms of the Cartan connection and Chern connection, as discussed frequently in the literature. However, there are other gravity theories that can be made to be equivalent to general relativity but are based on non-Riemannian geometry. Famous examples are the Teleparallel and Symmetric Teleparallel gravity theories. In this paper, we show how to obtain the geometry for Teleparallel gravity from Finsler geometry in terms of a ‘Teleparallel type’ connection.
Alginate hydrogels containing different concentrations of magnesium-containing poly(lactic-co-glycolic acid) microspheres for bone tissue engineering
Authors: Wang Lizhe , Li Yaxin , Jiang Shuai , Zhang Zhihao , Zhao Sinan , Song Yuru , Liu Jie , Tan Fei 
Published: July 2023

Abstract
The easy loss of crosslinking ions in alginate can result in structural collapse and loss of its characteristics as a bone scaffold. A novel injectable tissue engineering scaffold containing poly(lactic-co-glycolic acid) (PLGA) microspheres and alginate was fabricated to improve alginate’s physiochemical and biological properties. MgCO3 and MgO were loaded at a 1:1 ratio into PLGA microspheres to form biodegradable PLGA microspheres containing magnesium (PMg). Subsequently, different concentrations of PMg were mixed into a Ca2+ suspension and employed as crosslinking agents for an alginate hydrogel. A pure Ca2+ suspension was used as the alginate crosslinking agent in the control group. The influence of PMg on the physiochemical properties of the injectable scaffolds, including the surface morphology, degradation rate, Mg2+ precipitation concentration, and the swelling rate, was investigated. MC3T3-E1 cells were seeded onto the hydrogels to evaluate the effect of the resultant alginate on osteoblastic attachment, proliferation, and differentiation. The physicochemical properties of the hydrogels, including morphology, degradation rate, and swelling ratio, were effectively tuned by PMg. Inductively coupled plasma-optical emission spectroscopy results showed that, in contrast to those in pure PMg, the magnesium ions (Mg2+) in alginate hydrogel containing PMg microspheres (Alg-PMg) were released in a dose-dependent and slow-releasing manner. Additionally, Alg-PMg with an appropriate concentration of PMg not only improved cell attachment and proliferation but also upregulated alkaline phosphatase activity, gene expression of osteogenic markers, and related growth factors. These findings indicate that PMg incorporation can regulate the physicochemical properties of alginate hydrogels. The resultant hydrogel promoted cell attachment, matrix mineralization, and bone regeneration. The hydrogel described in this study can be considered a promising injectable scaffold for bone tissue engineering.
Effects of cold storage after cold acclimation on the fitness of Habrobracon hebetor (Hymenoptera: Braconidae)
Authors: Wei Lan , Yang Mao-Fa , Huang Ning , Ou Hou-Ding , Wang Xiu-Qin , Huang Yao , Yu Xiao-Fei 
Published: July 2023

Abstract
Habrobracon hebetor (Say) (Hymenoptera: Braconidae) is a cosmopolitan, idiobiont, and gregarious ectoparasitoid, which can parasitize the larvae of several pyralid and noctuid moths. However, adult parasitoids require cold storage to ensure that adequate individuals are available when a pest outbreak occurs. To understand the effects of cold storage after acclimation on offspring fitness of H. hebetor, the development, fecundity, population parameters, and paralysis rate of the F1 generation were evaluated using an age–stage, two-sex life table. Four pairing treatments were used in this study, with refrigerated males and females (ReF×ReM), unrefrigerated females and refrigerated males (UnF×ReM), refrigerated females and unrefrigerated males (ReF×UnM), and unrefrigerated females and males (UnF×UnM, control). Cold storage after acclimation had no significant effect on the fecundity or oviposition period of F0-generation H. hebetor. Moreover, the survival rate (Sa = 61.43%), proportion of females (Nf/N = 0.41), intrinsic rate of increase (r = 0.3450), finite rate of increase (λ = 1.4121), net reproduction rate (R0 = 149.47), and net paralysis rate (C0 = 74.52) of ReF×UnM and UnF×UnM (Sa = 50.00%, Nf/N = 0.34, r = 0.3297, λ = 1.3881, R0 = 155.69, C0 = 62.90, respectively) treatments were significantly higher than those of the ReF×ReM treatment (Sa = 45%, Nf/N = 0.16, r = 0.2277, λ = 1.2558, R0 = 68.81, C0 = 31.61, respectively) (except for the Sa of UnF×UnM treatment), and there was no significant difference between the 2 treatments. Overall, it is advisable to avoid simultaneous cold storage of female and male parasitoids or to add unrefrigerated males appropriately when using cold-stored parasitoids to control pests.
Relative Density as a Standardizing Metric for the Development of Size-Density Management Charts
Authors: Ray David , Seymour Robert , Fraver Shawn , Berrill John-Pascal , Kenefic Laura , Rogers Nicole , Weiskittel Aaron 
Published: July 2023

AbstractStand density management is central to achieving diverse silvicultural objectives. Decision-support tools in this domain range from expert opinion to sophisticated computer models that vary by forest type, region, and organization. The graphical frameworks represented by density management diagrams (DMDs) and stocking guides (SGs), collectively called size-density management charts (SDMCs), are well established and balance quantitative rigor with user accessibility. Regional differences in species composition and site quality are known to influence maximum size-density relationships, historically limiting the development of reliable charts. Advances in statistical modeling and data availability are overcoming this issue and should encourage more widespread use. We briefly review the history of SDMCs and propose the adoption of relative density based on stand density index as a logical metric for linking the DMD and SG formats. Examples of SDMC construction and use are illustrated for spruce-fir stands in Maine, USA.Study Implications: Recognition of the importance of stand density management has increased in recent years owing to its potential to address threats such as susceptibility to catastrophic wildfires and forest health issues exacerbated by environmental stress. Natural resource managers will benefit from adopting a language around density management that is both biologically grounded and consistent. A relative density framework is compatible with the two primary types of size-density management charts and thus meets this objective well. Relative density provides an ideal launching point for articulating levels of stand density, or stocking, to meet diverse management objectives determined under relevant socioecological constraints.
Positive outcome of diaphragm covering and total pleural covering techniques for catamenial pneumothorax
Authors: Koike Sachie , Kobayashi Nobutaka , Miyazawa Masahisa 
Published: July 2023

Abstract
Catamenial pneumothorax (CP) is reported to be caused by the endometriosis of diaphragm, lung and parietal pleura. Therefore, the resection of endometriotic lesion in these organs is reported as effective surgical treatment. Overlooking of endometrial tissues during the operation is believed to be the cause of recurrence after surgical treatment. To address this problem, we underwent total diaphragm covering (TDC) and total pleural covering with sheets of oxidized regenerated cellulose mesh. This report described two CP cases that underwent total diaphragm covering (TDC) and total pleural covering. Both patients were followed up for 1 year without recurrence.
A 6-year-old boy with an atypical liver neoplasm harboring a novel RPS6KA3 variant
Authors: Bustamante Daniel , Abadie Jude 
Published: July 2023

Abstract
Pediatric hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) are primary liver malignant neoplasms with 5-year event-free survival of &gt;80% and &lt;30%, respectively. In these patients, α-fetoprotein levels can guide surgical intervention and monitor disease progression. Although histology and immunohistochemical stains support diagnosis, genetic testing can elucidate mechanisms that drive pathogenesis. Pediatric HBL and HCC harbor well-characterized molecular signatures such as alterations in CTNNB1, TERT, and AXIN1 that alter the Wnt/β-catenin pathway. Approximately 8% of individuals with HCC harbor RPS6KA3 variants that appear with other gene mutations. Herein, we report a novel solitary pathogenic RPS6KA3 variant finding in a 6-year-old boy whose final diagnosis was hepatocellular malignant neoplasm, not otherwise specified.