bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the influence of agent modality and expression on agent-mediated fairness behaviours
Authors: Yip Hiu Lam , Petrini Karin 
Published: May 2023

AbstractWith technological developments, individuals are increasingly able to delegate tasks to autonomous agents that act on their behalf. This may cause individuals to behave more fairly, as involving an agent representative encourages individuals to strategise ahead and therefore adhere to social norms of fairness. Research suggests that an audio smiling agent may further promote fairness as it provides a signal of honesty and trust. What is still unclear is whether presenting a multimodal smiling agent (by using visual and auditory cues) rather than a unimodal smiling agent as normally available commercially (using only an auditory cue e.g., Siri) could amplify the impact of smiles. In the present study, participants (N = 86) played an ultimatum game either directly with another player (control), through a smiling multimodal and unimodal agent or through a neutral multimodal and unimodal agent. Participants’ task was to offer a number of tickets to the other player from a fixed amount. Results showed that when playing the ultimatum game through a smiling multimodal agent, participants offered more tickets to the other player compared to the control condition and the other agent conditions. Hence, exploiting multisensory perception to enhance an agent’s expression may be key for increasing individuals' pro-social behaviour when interacting through such an agent.
Cardiac Perfusion and Innervation Assessment by CZT-SPECT: Have a Look to Simultaneous Dual-isotope Protocol
Authors: D’Antonio Adriana , Falzarano Maria , Reina Fabrizio , Assante Roberta , Zampella Emilia , Maio Francesca , Buongiorno Pietro , Panico Mariarosaria , Mainolfi Ciro Gabriele , Mannarino Teresa , Cuocolo Alberto , Acampa Wanda 
Published: May 2023

Abstract
Purpose of Review
The purpose of this review is to provide a summary on the status of the art of simultaneous perfusion-innervation imaging by CZT-SPECT and to clarify its potential applications in clinical practice.

Recent Findings
Introduction of CZT cameras represented a critical breakthrough in nuclear cardiology. Although it has been demonstrated that cardiac innervation may be easily assessed by CZT-SPECT, as for now, there are only few studies investigating cardiac perfusion and innervation with simultaneous dual-isotope imaging by CZT cameras.

Summary
Perfusion and innervation assessment by CZT camera is a feasible tool, allowing to reduce radiation dose exposure and acquisition time, thanks to CZT better spatial, temporal, and energy resolution, with higher compliance by patients. Moreover, this technique allows to integrate regional evaluation of myocardial perfusion/innervation status, providing more accurate information for risk stratification of different cardiac disease.
Deep face segmentation for improved heart and respiratory rate estimation from videos
Authors: Fiedler Marc-André , Werner Philipp , Rapczyński Michał , Al-Hamadi Ayoub 
Published: May 2023

AbstractThe selection of a suitable region of interest (ROI) is of great importance in camera-based vital signs estimation, as it represents the first step in the processing pipeline. Since all further processing relies on the quality of the signal extracted from the ROI, the tracking of this area is decisive for the performance of the overall algorithm. To overcome the limitations of classical approaches for the ROI, such as partial occlusions or illumination variations, a custom neural network for pixel-precise face segmentation called FaSeNet was developed. It achieves better segmentation results on two datasets compared to state-of-the-art architectures while maintaining high execution efficiency. Furthermore, the Matthews Correlation Coefficient was proposed as a loss function providing a better fitting of the network weights than commonly applied losses in the field of multi-class segmentation. In an extensive evaluation with a variety of algorithms for vital signs estimation, our FaSeNet was able to achieve better results in both heart and respiratory rate estimation. Thus, a ROI for vital signs estimation could be created that is superior to other approaches.
The role of myeloid-derived suppressor cells in liver cancer
Authors: Zhou Shiyue , Zhao Zixuan , Zhong Hao , Ren Zehao , Li Yuye , Wang Hong , Qiu Yuling 
Published: May 2023

AbstractMDSCs are immature myeloid immune cells, which accumulate in models of liver cancer to reduce effector immune cell activity, contribute to immune escape and treatment resistance. The accumulation of MDSCs suppresses the role of CTL and the killing effects of NK cells, induces the accumulation of Treg cells, and blocks the antigen presentation of DCs, thus promoting the progression of liver cancer. Recently, immunotherapy has emerged a valuable approach following chemoradiotherapy in the therapy of advanced liver cancer. A considerable increasing of researches had proved that targeting MDSCs has become one of the therapeutic targets to enhance tumor immunity. In preclinical study models, targeting MDSCs have shown encouraging results in both alone and in combination administration. In this paper, we elaborated immune microenvironment of the liver, function and regulatory mechanisms of MDSCs, and therapeutic approaches to target MDSCs. We also expect these strategies to supply new views for future immunotherapy for the treatment of liver cancer.
Evolutionary Techniques for the Solution of Bio-Heat Equation Arising in Human Dermal Region Model
Authors: Ahmad Iftikhar , Ilyas Hira , Hussain Syed Ibrar , Raja Muhammad Asif Zahoor 
Published: May 2023

AbstractThe proposed research work analyzes the bio-inspired problem through artificial neural networks with a feed-forward approach utilized to approximate the numerical results for singular nonlinear bio-heat equation (BHE) with boundary conditions based on four different scenarios created on the variation of environmental temperature to illustrate the effects of temperature on the human dermal region. The log-sigmoid function is used to construct the fitness function, while the optimization solvers: pattern search and genetic algorithm, are then hybridized with the active set technique, interior point technique, sequential quadratic programming for accurate and reliable results of the proposed BHE with various scenarios where the convergence of the numerical results is also analyzed. Moreover, a comparison of the proposed technique is expressed through residual error that reveals the nature of the numerical results and their efficiency. Additionally, a comprehensive statistical analysis is presented for the designed technique to better illustrate the accuracy, reliability, and efficiency of the obtained results.
Immune-Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults
Authors: Jia Zhenghu , Ren Zhiyao , Ye Dongmei , Li Jiawei , Xu Yan , Liu Hui , Meng Ziyu , Yang Chengmao , Chen Xiaqi , Mao Xinru , Luo Xueli , Yang Zhe , Ma Lina , Deng Anyi , Li Yafang , Han Bingyu , Wei Junping , Huang Chongcheng , Xiang Zheng , Chen Guobing , Li Peiling , Ouyang Juan , Chen Peisong , Luo Oscar Junhong , Gao Yifang , Yin Zhinan 
Published: May 2023

AbstractAgeing is often accompanied with a decline in immune system function, resulting in immune ageing. Numerous studies have focussed on the changes in different lymphocyte subsets in diseases and immunosenescence. The change in immune phenotype is a key indication of the diseased or healthy status. However, the changes in lymphocyte number and phenotype brought about by ageing have not been comprehensively analysed. Here, we analysed T and natural killer (NK) cell subsets, the phenotype and cell differentiation states in 43,096 healthy individuals, aged 20–88 years, without known diseases. Thirty-six immune parameters were analysed and the reference ranges of these subsets were established in different age groups divided into 5-year intervals. The data were subjected to random forest machine learning for immune-ageing modelling and confirmed using the neural network analysis. Our initial analysis and machine modelling prediction showed that naïve T cells decreased with ageing, whereas central memory T cells (Tcm) and effector memory T cells (Tem) increased cluster of differentiation (CD) 28-associated T cells. This is the largest study to investigate the correlation between age and immune cell function in a Chinese population, and provides insightful differences, suggesting that healthy adults might be considerably influenced by age and sex. The age of a person's immune system might be different from their chronological age. Our immune-ageing modelling study is one of the largest studies to provide insights into ‘immune-age’ rather than ‘biological-age’. Through machine learning, we identified immune factors influencing the most through ageing and built a model for immune-ageing prediction. Our research not only reveals the impact of age on immune parameter differences within the Chinese population, but also provides new insights for monitoring and preventing some diseases in clinical practice.
Naked men on the run, regression to childhood: cultural figures of the trauma during the First World War
Authors: Fiorino Vinzia 
Published: May 2023

AbstractAlthough there is a wide-ranging historiography dealing with psychoneurosis, various manifestations of psychic suffering widespread among traumatised soldiers during the Great War have received less attention. This essay, based on an analysis of soldiers' clinical files in Italian psychiatric hospitals, draws out these phenomena. The main forms assumed by this kind of trauma are three: soldiers who strip off their uniform and wander around naked; a sort of regression to childhood; and a particular type of hysteria. The essay stresses how existingstereotypes about women were adapted to form a new way of describing masculinity in crisis, and the new political subject: the masses. Too many emotions, too many nerves, define the affected men: they are subjects deprived of personality, and their predicament highlights the transition from soldier-hero to mass-soldier.
Racial Integration, Cost-Benefit Analysis, and Philosophical Humility
Authors: Stanley Sharon 
Published: May 2023

AbstractD. C. Matthew offers an original and important critique of racial integration. His claim that integration will aggravate phenotypic devaluation of blackness, threatening black self-worth, is persuasive. However, his stronger normative argument that blacks should reject integration as a consequence because the potential harms to black self-worth outweigh its purported benefits is less convincing, as it rests on a dubious cost-benefit analysis. Ultimately, I argue that we should resist the impulse to offer a definitive cost-benefit analysis of racial integration in any case, given the uncertainty of such a complex process unfolding in a speculative future.
Integration and Reaction
Authors: Sundstrom Ronald R. 
Published: May 2023

AbstractD. C. Matthew argues that although integration offers blacks social and economic benefits, it also creates the conditions for phenotypic devaluation that leads to harm against black self-worth and servile behaviour. Therefore, he advises against integration because the resulting self-worth harms outweigh the benefits of integration. I argue that Matthew's cost-benefit calculation against integration lacks the requisite evidence, and amounts to a luxury belief that will result in more harm. Moreover, his interpretation of behaviour — which he construes as being indicative of a lack of self-worth — is unfounded. Further, his cost-benefit calculation results in socially reactionary sexual policing and ideological purity tests.
L'argument de Quine contre les logiques déviantes
Authors: Wagner Henri 
Published: May 2023

RésuméL'ambition de cet article est de restituer la radicalité de l'argument central contre les logiques déviantes que W.V.O. Quine déploie dans Philosophy of Logic. Cet argument a pour objet de mettre au jour l'inanité du concept de logique déviante, c'est-à-dire son caractère dénué de sens. En rendre compte requiert alors de prendre la mesure de sa dimension anti-psychologiste. Nous tâchons ainsi de montrer que le défi le plus radical de Quine ne consiste pas à opposer au logicien déviant que changer de lois logiques, c'est changer la signification des termes de constantes logiques.
Investigating the shared genetic architecture of post-traumatic stress disorder and gastrointestinal tract disorders: a genome-wide cross-trait analysis
Authors: Zhou Siquan , Luo Hang , Tian Ye , Li Haoqi , Zeng Yaxian , Wang Xiaoyu , Shan Shufang , Xiong Jingyuan , Cheng Guo 
Published: May 2023

AbstractBackgroundObservational studies suggest a correlation between post-traumatic stress disorder (PTSD) and gastrointestinal tract (GIT) disorders. However, the genetic overlap, causal relationships, and underlining mechanisms between PTSD and GIT disorders were absent.MethodsWe obtained genome-wide association study statistics for PTSD (23 212 cases, 151 447 controls), peptic ulcer disease (PUD; 16 666 cases, 439 661 controls), gastroesophageal reflux disease (GORD; 54 854 cases, 401 473 controls), PUD and/or GORD and/or medications (PGM; 90 175 cases, 366 152 controls), irritable bowel syndrome (IBS; 28 518 cases, 426 803 controls), and inflammatory bowel disease (IBD; 7045 cases, 449 282 controls). We quantified genetic correlations, identified pleiotropic loci, and performed multi-marker analysis of genomic annotation, fast gene-based association analysis, transcriptome-wide association study analysis, and bidirectional Mendelian randomization analysis.ResultsPTSD globally correlates with PUD (rg = 0.526, p = 9.355 × 10−7), GORD (rg = 0.398, p = 5.223 × 10−9), PGM (rg = 0.524, p = 1.251 × 10−15), and IBS (rg = 0.419, p = 8.825 × 10−6). Cross-trait meta-analyses identify seven genome-wide significant loci between PTSD and PGM (rs13107325, rs1632855, rs1800628, rs2188100, rs3129953, rs6973700, and rs73154693); three between PTSD and GORD (rs13107325, rs1632855, and rs3132450); one between PTSD and IBS/IBD (rs4937872 and rs114969413, respectively). Proximal pleiotropic genes are mainly enriched in immune response regulatory pathways, and in brain, digestive, and immune systems. Gene-level analyses identify five candidates: ABT1, BTN3A2, HIST1H3J, ZKSCAN4, and ZKSCAN8. We found significant causal effects of GORD, PGM, IBS, and IBD on PTSD. We observed no reverse causality of PTSD with GIT disorders, except for GORD.ConclusionsPTSD and GIT disorders share common genetic architectures. Our work offers insights into the biological mechanisms, and provides genetic basis for translational research studies.
A domain-theoretic framework for robustness analysis of neural networks
Authors: Zhou Can , Shaikh Razin A. , Li Yiran , Farjudian Amin 
Published: May 2023

AbstractA domain-theoretic framework is presented for validated robustness analysis of neural networks. First, global robustness of a general class of networks is analyzed. Then, using the fact that Edalat’s domain-theoreticL-derivative coincides with Clarke’s generalized gradient, the framework is extended for attack-agnostic local robustness analysis. The proposed framework is ideal for designing algorithms which are correct by construction. This claim is exemplified by developing a validated algorithm for estimation of Lipschitz constant of feedforward regressors. The completeness of the algorithm is proved over differentiable networks and also over general position${\mathrm{ReLU}}$networks. Computability results are obtained within the framework of effectively given domains. Using the proposed domain model, differentiable and non-differentiable networks can be analyzed uniformly. The validated algorithm is implemented using arbitrary-precision interval arithmetic, and the results of some experiments are presented. The software implementation is truly validated, as it handles floating-point errors as well.
Soil Moisture Variations From Boreal Forests to the Tundra
Authors: Kemppinen J. , Niittynen P. , Rissanen T. , Tyystjärvi V. , Aalto J. , Luoto M. 
Published: May 2023

AbstractSoil moisture has a profound influence on life on Earth, and this vital water resource varies across space and time. Here, we explored soil moisture variations in boreal forest and tundra environments, where comprehensive soil moisture datasets are scarce. We installed soil moisture sensors up to 14 cm depth at 503 measurement sites within seven study areas across northern Europe. We recorded 6,138,528 measurements to capture soil moisture variations of the snowless season from April to September 2020. We described the spatio‐temporal patterns of soil moisture, and test how these patterns are linked to topography and how these links vary in space and time. We found large spatial variation and often less pronounced temporal variation in soil moisture across the measurement sites within all study areas. We found that throughout the measurement periods both univariate and multivariate models with topographic predictors showed great temporal variation in their performance and in the relative influence of the predictors within and across the areas. We found that the soil moisture‐topography relationships are site‐specific, as the topography‐based models often performed poorly when transferred from one area to another. There was no general solution that would work well in all the study areas when modeling soil moisture variation with topography. This should be carefully considered before applying topographic proxies for soil moisture. Overall, these data and results highlight the strong spatio‐temporal heterogeneity of soil moisture conditions in boreal forest and tundra environments.
Pangenomics of the death cap mushroom Amanita phalloides, and of Agaricales, reveals dynamic evolution of toxin genes in an invasive range
Authors: Drott Milton T , Park Sung Chul , Wang Yen-wen , Harrow Lynn , Keller Nancy P , Pringle Anne 
Published: May 2023

Abstract
The poisonous European mushroom Amanita phalloides (the “death cap”) is invading California. Whether the death caps’ toxic secondary metabolites are evolving as it invades is unknown. We developed a bioinformatic pipeline to identify the MSDIN genes underpinning toxicity and probed 88 death cap genomes from an invasive Californian population and from the European range, discovering a previously unsuspected diversity of MSDINs made up of both core and accessory elements. Each death cap individual possesses a unique suite of MSDINs, and toxin genes are significantly differentiated between Californian and European samples. MSDIN genes are maintained by strong natural selection, and chemical profiling confirms MSDIN genes are expressed and result in distinct phenotypes; our chemical profiling also identified a new MSDIN peptide. Toxin genes are physically clustered within genomes. We contextualize our discoveries by probing for MSDINs in genomes from across the order Agaricales, revealing MSDIN diversity originated in independent gene family expansions among genera. We also report the discovery of an MSDIN in an Amanita outside the “lethal Amanitas” clade. Finally, the identification of an MSDIN gene and its associated processing gene (POPB) in Clavaria fumosa suggest the origin of MSDINs is older than previously suspected. The dynamic evolution of MSDINs underscores their potential to mediate ecological interactions, implicating MSDINs in the ongoing invasion. Our data change the understanding of the evolutionary history of poisonous mushrooms, emphasizing striking parallels to convergently evolved animal toxins. Our pipeline provides a roadmap for exploring secondary metabolites in other basidiomycetes and will enable drug prospecting.
Whey-based diet containing medium chain triglycerides modulates the gut microbiota and protects the intestinal mucosa from chemotherapy while maintaining therapy efficacy
Authors: Wardill Hannah R. , Da Silva Ferreira Ana Rita , Kumar Himanshu , Bateman Emma H. , Cross Courtney B. , Bowen Joanne M. , Havinga Rick , Harmsen Hermie J. M. , Knol Jan , Dorresteijn Bram , van Dijk Miriam , van Bergenhenegouwen Jeroen , Tissing Wim J. E. 
Published: May 2023

AbstractCytotoxicity (i.e. cell death) is the core mechanism by which chemotherapy induces its anti-cancer effects. Unfortunately, this same mechanism underpins the collateral damage it causes to healthy tissues. The gastrointestinal tract is highly susceptible to chemotherapy’s cytotoxicity, resulting in ulcerative lesions (termed gastrointestinal mucositis, GI-M) that impair the functional capacity of the gut leading to diarrhea, anorexia, malnutrition and weight loss, which negatively impact physical/psychological wellbeing and treatment adherence. Preventing these side effects has proven challenging given the overlapping mechanisms that dictate chemotherapy efficacy and toxicity. Here, we report on a novel dietary intervention that, due to its localized gastrointestinal effects, is able to protect the intestinal mucosal from unwanted toxicity without impairing the anti-tumor effects of chemotherapy. The test diet (containing extensively hydrolyzed whey protein and medium chain triglycerides (MCTs)), was investigated in both tumor-naïve and tumor-bearing models to evaluate its effect on GI-M and chemo-efficacy, respectively. In both models, methotrexate was used as the representative chemotherapeutic agent and the diet was provided ad libitum for 14 days prior to treatment. GI-M was measured using the validated biomarker plasma citrulline, and chemo-efficacy defined by tumor burden (cm3/g body weight). The test diet significantly attenuated GI-M (P = 0.03), with associated reductions in diarrhea (P < 0.0001), weight loss (P < 0.05), daily activity (P < 0.02) and maintenance of body composition (P < 0.02). Moreover, the test diet showed significant impact on gut microbiota by increasing diversity and resilience, whilst also altering microbial composition and function (indicated by cecal short and brained chain fatty acids). The test diet did not impair the efficacy of methotrexate against mammary adenocarcinoma (tumor) cells. In line with the first model, the test diet minimized intestinal injury (P = 0.001) and diarrhea (P < 0.0001). These data support translational initiatives to determine the clinical feasibility, utility and efficacy of this diet to improve chemotherapy treatment outcomes.
Intricacies of TGF-β signaling in Treg and Th17 cell biology
Authors: Wang Junying , Zhao Xingqi , Wan Yisong Y. 
Published: May 2023

AbstractBalanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are central to the balance between immune tolerance and immune rejection. Th cells adopt distinct functions to maintain tolerance and clear pathogens. Dysregulation of Th cell function often leads to maladies, including autoimmunity, inflammatory disease, cancer, and infection. Regulatory T (Treg) and Th17 cells are critical Th cell types involved in immune tolerance, homeostasis, pathogenicity, and pathogen clearance. It is therefore critical to understand how Treg and Th17 cells are regulated in health and disease. Cytokines are instrumental in directing Treg and Th17 cell function. The evolutionarily conserved TGF-β (transforming growth factor-β) cytokine superfamily is of particular interest because it is central to the biology of both Treg cells that are predominantly immunosuppressive and Th17 cells that can be proinflammatory, pathogenic, and immune regulatory. How TGF-β superfamily members and their intricate signaling pathways regulate Treg and Th17 cell function is a question that has been intensely investigated for two decades. Here, we introduce the fundamental biology of TGF-β superfamily signaling, Treg cells, and Th17 cells and discuss in detail how the TGF-β superfamily contributes to Treg and Th17 cell biology through complex yet ordered and cooperative signaling networks.