bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Materializing Rhetorics of Early Music
Authors: Gibson Jonathan 
Published: July 2023

Ever since Pierre Schaeffer’s admonition in his Traité des objets musicaux of 1966 to avoid “preoccupations about how things are made” by “turning our backs on the instrument” and “listening to sound objects with their instrumental causes hidden,” materially oriented studies of sound have attended increasingly to sound objects and to ontologies of sound broadly, often turning away from considerations of the tactile materiality of sound sources. Deviating from this trend, this study focuses squarely on sound source materiality, and on our motivations for either foregrounding or dismissing it in our verbal, visual, and sonic rhetorics.
As a case study, I turn to the Early Music movement, understood here as a constellation of cultures invested in the consumption and historically informed production of mostly European music written before c.1750. Seeking to distance themselves from the classical music mainstream, this movement’s participants have often adopted rhetorical stances that foreground and celebrate the materiality of sound sources, particularly instruments and their constituent parts. Rooted partly in the assumption that instruments may act as material conduits to imagined historical soundscapes, these materializing rhetorics are also born out of affinities among producers and consumers of Early Music for musical works whose poetics are themselves bound up in materiality—and in turn, for particular instruments whose sounds tend to animate such poetics. Selected theories of Michel Chion, Roland Barthes, and others are invoked in an effort to situate the verbal, visual, and sonic materializing rhetorics of Early Music cultures within broader discussions of sound source materiality.
A tale of two inhibitors: diarylquinolines and squaramides
Authors: Chen James , Ekiert Damian C 
Published: July 2023

The diarylquinoline bedaquiline (BDQ) is an FDA‐approved drug for the treatment of multidrug‐resistant tuberculosis that targets the mycobacterial adenosine triphosphate (ATP) synthase, a key enzyme in cellular respiration. In a recent study, Courbon et al (2023) examine the interaction between Mycobacterium smegmatis ATP synthase with the second generation diarylquinoline TBAJ‐876 and the squaramide inhibitor SQ31f, showing that both drugs prevent the rotatory motions needed for enzymatic function.
MOV10 recruits DCP2 to decap human LINE‐1 RNA by forming large cytoplasmic granules with phase separation properties
Authors: Liu Qian , Yi Dongrong , Ding Jiwei , Mao Yang , Wang Shujie , Ma Ling , Li Quanjie , Wang Jing , Zhang Yongxin , Zhao Jianyuan , Guo Saisai , Liu Zhenlong , Guo Fei , Zhao Dongbing , Liang Chen , Li Xiaoyu , Peng Xiaozhong , Cen Shan 
Published: July 2023

AbstractLong interspersed element 1 (LINE‐1) is the only active autonomous mobile element in the human genome. Its transposition can exert deleterious effects on the structure and function of the host genome and cause sporadic genetic diseases. Tight control of LINE‐1 mobilization by the host is crucial for genetic stability. In this study, we report that MOV10 recruits the main decapping enzyme DCP2 to LINE‐1 RNA and forms a complex of MOV10, DCP2, and LINE‐1 RNP, exhibiting liquid–liquid phase separation (LLPS) properties. DCP2 cooperates with MOV10 to decap LINE‐1 RNA, which causes degradation of LINE‐1 RNA and thus reduces LINE‐1 retrotransposition. We here identify DCP2 as one of the key effector proteins determining LINE‐1 replication, and elucidate an LLPS mechanism that facilitates the anti‐LINE‐1 action of MOV10 and DCP2.
Comparative reproduction of the female horse, elephant and rhinoceros: implications for advancing assisted reproductive technologies
Authors: Meuffels-Barkas Janine , Wilsher Sandra , Allen W R Twink , Ververs Cyrillus , Lueders Imke 
Published: July 2023

Recent loss of rhinoceros subspecies has renewed interest in using more advanced assisted reproductive technologies (ART) in rhinoceroses and elephants. Currently, only semen collection, semen preservation and artificial insemination (AI) have been used repeatedly with success in these species. Although ovum pick-up (OPU) and intra-cytoplasmic sperm injection (ICSI) have been reported recently in rhinoceroses, the techniques are not yet optimised. In contrast, multiple ART applications are routinely used in the horse. Since elephants and rhinoceroses share some reproductive features with equids, we postulate that procedures such as OPU, ICSI, in vitro fertilisation (IVF) and embryo transfer (ET), which are well established in the horse, may represent a basis to develop protocols for endangered pachyderms. In this review, we summarise current knowledge on reproductive physiology relevant to ART. We discuss the current state of ART in all three families and the requirements for the successful implementation of OPU, ICSI, IVF and ET in these species.

Lay summary
Wild rhinoceros and elephant populations are facing ongoing threats; therefore, additional measures are required to protect these species for future generations. Assisted reproductive technologies (ART) include the collection of semen to directly inseminate females or to fertilise oocytes (eggs) in a laboratory to produce embryos, which can be transferred into a recipient female at a later date. While these techniques are routinely used in humans and domestic animals such as the horse, more research is needed to incorporate such technologies into the breeding of elephants and rhinoceroses. As the horse is the closest related domestic species to the rhinoceros, it may serve as the best possible role model. We discuss the current state of ART in the horse, elephant and rhinoceros and the possibilities for future use of these techniques in breeding such endangered animals.
Influência da artroplastia de quadril no desempenho de atividades funcionais, risco de quedas e qualidade de vida de idosos institucionalizados
Authors: Malezan Fleig Tania Cristina , Périco Eduardo , Grave Magali Teresinha Quevedo , Silva Joice 
Published: July 2023

Introdução: o envelhecimento é um processo caracterizado por modificações anatômicas e fisiológicas; fenômeno complexo que envolve aspectos socioculturais, políticos e econômicos em interação dinâmica e permanente com a dimensão biológica e subjetiva dos indivíduos. Causa ao longo do tempo, perdas osteomusculares, aumentando o risco de quedas e fraturas de quadril. Considerando a estrutura familiar moderna, novas exigências sociais e a necessidade de cuidados direcionados, muitos destes idosos passam a residir em Instituições de Longa Permanência (ILPI). Objetivo: verificar a influência da artroplastia de quadril no desempenho de atividades funcionais, risco de quedas e qualidade de vida de idosos institucionalizados. Método: estudo de casos múltiplos, exploratório, descritivo e transversal, de análise quantitativa. Participaram 5 idosos com idades entre 65 e 80 anos (média=71 anos; DP:5,87), sendo 03 homens e 02 mulheres, que realizaram cirurgia de artroplastia de quadril. Os instrumentos de coleta de dados foram o Índice de Barthel, Questionário SF-36 (Short-Form Health Survey), Escala de Tinetti e duas perguntas comparando as respostas do antes e depois da cirurgia. Resultados: através do Índice de Barthel verificou-se que 03 (60%) idosos apresentam dependência leve, 01 (20%) dependência moderada, e 01 (20%) é independente em atividades de vida diária. No SF-36 observou-se que idosos apresentam menor média no estado geral de saúde (EGS) (+-41,0; DP: 20,7) e maior média no item limitação por aspectos emocionais (LAE) (+-73,5; DP: 27,8). O Índice de Tinetti apontou que 03 (60%) dos idosos apresentam alto risco de quedas e 02 (40%) apresentam baixo risco de quedas; 04 (80%) referiram que sua vida melhorou após a cirurgia. Conclusão: a artroplastia de quadril, de forma geral, influenciou positivamente na qualidade de vida dos idosos, entretanto, o EGS e o risco de quedas são uma preocupação presente nesta população.
The main non-invasive neuromodulatory techniques: an infographic
Authors: Lopes Tiago da Silva , Lopes Larissa Conceição Dias , Lopes Tallya da Silva , Lopes Tallita da Silva , De Oliveira Lilian Becerra 
Published: July 2023

INTRODUCTION: This infographic aims to present the main non-invasive neuromodulatory techniques that can be used to assess and/or modulate central nervous system excitability. Single- and paired-pulse transcranial magnetic stimulation (TMS) can be used to assess brain excitability through the delivery of magnetic pulses over the cerebral cortex. The motor evoked potential is an indirect measure of motor cortex excitability and is the most used cortical measure of excitability. RESULTS: Neuromodulation may be achieved through several techniques, which may be used to promote top-down or bottom-up effects. Among the top-down techniques is direct current stimulation (DCS) which can change its nomenclature according to the stimulation target, for example, transcranial (tDCS), or cerebellar (ctDCS). In addition, also can be included in top-down techniques the transcranial random noise stimulation (tRNS), transcranial alternate current stimulation (tACS), and repetitive TMS (rTMS). On other hand, the bottom-up techniques include the peripheral electrical stimulation (PES), transcutaneous auricular vagus nerve stimulation (taVNS), transcutaneous spinal direct current stimulation (tsDCS), and repetitive peripheral magnetic stimulation (rPMS). CONCLUSION: The neuromodulatory effects are dependent on several parameters that can be specific to physical principles (electrical or magnetic). For example, in repetitive P/TMS the frequency, type and angular orientation of coil, distance between the coil and the brain, pulse waveform, and pattern of stimulation are presented as important parameters able to interfere with the quality of stimulation. The same can be observed in tDCS, ctDCS, and tsDCS with the polarity and shape and montage of electrode, intensity, site and duration of stimulation, and current density.
Is skin grafting in the patient with cutaneous sporotrichosis the definitive therapy?
Authors: Monterrubio Nayeli Marilú López , Sánchez Omar Sosa , Montaño Mónica Heredia , Barrientos Cheryl Zilahy Díaz , Tovar Fernando Navarro , Trujillo Hector Alejandro Carzolio 
Published: July 2023

Sporotrichosis is a subacute to chronic infection caused by the dimorphic fungal genus Sporothrix. The infection usually affects the skin and subcutaneous tissues, but occasionally it can occur at other sites, mainly in immunocompromised patients. The symptoms of extracutaneous sporotrichosis can be subtle and diagnosis is often delayed. A 54-year-old male was received, originally from Huajuapan de León, Oaxaca; who was with an established diagnosis of type 2 diabetes mellitus; later admitted by the general surgery service with a diagnosis of necrotizing fasciitis of the left and right thoracic limb. When culture was collected with Sporothrix schenckii report, management was established with itraconazole, potassium iodide and with subsequent addition of amphotericin B, with antibiotic therapy directed for superinfection by opportunistic agents. After multiple surgical cleanings with degradation of necrotic tissue, implementation of negative pressure system and amputation of nonviable fingers, it was decided to proceed with the application of skin autografts, despite the persistence of the agent in subsequent culture reports, which are fully integrated, without evidence of new ulcerodular lesions so far. Although there are currently no parameters defined in the literature that guide the time or the appropriate conditions to perform skin grafts in the areas affected by cutaneous sporotrichosis, there are, on the contrary, reports of successful cases where surgical management has been effective even in the presence of positive cultures for Sporothrix schenckii. We consider that these results open the panorama of options for the current management of cutaneous sporotrichosis, making it necessary to consider surgical management in the therapeutic range of the same, allowing the deliberation on other more conservative options before the failure of classical therapy and the imminence of amputation.
A randomized controlled open labelled study to evaluate clinical efficacy of Bacillus clausii (TIL 19T, TIL 21C, TIL 28S, TIL 30R) in the management of acute diarrhoea in children
Authors: Shetty Satvik A , A Ramnath , Valliappan Subramanian , Kumar Dinesh , Arasan R Ezhil 
Published: July 2023

Acute Diarrhoea in children is the most frequent gastroenterological disorder and is a common cause of dehydration in children. The management of acute diarrhoea consists of the replacement of lost fluid with glucose-electrolyte oral rehydration solution. Probiotics have been used as adjunctive therapy in the treatment of acute diarrhoea. In this study we evaluated the efficacy of Bacillus clausii (TIL 19T, TIL 21C, TIL 28S, TIL 30R) in management of Acute diarrhoea in children. 48 children aged between 6 months and 15 years with acute bacterial gastroenteritis or acute viral gastroenteritis were included in the study. The study group received poly antibiotic resistant B. clausii strains (TIL 19T, TIL 21C, TIL 28S, TIL 30R)as a probiotic along with standard treatment for diarrhoea and the control group received standard treatment for diarrhoea without B. clausii. The results at the end of 48 hours showed a significant improvement in very severe and high grade diarrhoea category in the children belonging to the study group. That is, all patients had recovered to low grade or normal grade (P &#60; 0.01). Analysis of diarrhoeal stool group showed 64% of children in the control group continued to have loose stools as compared to just 24% in the study group (P &#60; 0.01). No serious adverse events were recorded in both the groups. The use of B. clausii strains(TIL 19T, TIL 21C, TIL 28S, TIL 30R)in Acute Diarrhoea in children has shown to improve the recovery time from the illness and improvement in stool consistency due to its probiotic effect.
МЕТОД КОДУВАННЯ НИЗЬКОІНФОРМАТИВНИХ СЕГМЕНТІВ ВІДЕОІНФОРМАЦІЙ-НОГО РЕСУРСУ ДЛЯ ПІДВИЩЕННЯ ЇХ ДОСТУПНОСТІ
Authors: Бучік Сергій , Бабенко Юрій , Цімура Юрій , Пчельніков Сергій , Ушань Владислав 
Published: July 2023

Обґрунтовується значимість відеоінформаційного ресурсу для багатьох прикладних сфер. В тому числі сюди відносяться системи управління, відеоконтролю, моніторингу, відеоконференційного зв’язку. Показується наявність дисбалансу між рівнями інтенсивності відеопотоку та існуючими характеристиками щодо забезпечення пропускної здатності інформаційно-телекомунікаційних систем. Це призводить до суперечності між означеними вимогами до якісних характеристик відеосервісів. Звідси існує потреба відносно підвищення рівня доступності відеоінформаційних ресурсів в умовах забезпечення їх цілісності з використанням інформаційних та телекомунікаційних технологій. Означені технології використовуються на різних етапах доставки відеоінформації. Одним з напрямком вирішення сформульованої проблеми є використання технологій кодування відеопотоку. Однак існуючи підходи не достатньо враховують семантичну та структурну вагу сегментів. Це призводить до виникнення втрат цілісності в умовах збільшення рівня стиснення відеоданих. Звідси, для сучасних технологій кодування існує протиріччя. Воно обумовлено наявністю обернено пропорційної залежності між об’ємом кодованих сегментів та рівнем їх семантичної цілісності. Обґрунтовано, що низькоінформативні сегменти дозволяють застосовувати нові процеси обробки. Вони забезпечують певне зменшення бітового об’єму сегментів. Показано, що це створює умови для підвищення загального рівня цілісності відеоресурсів. Тому мета статті полягає у розробці методу кодування низькоінформативних сегментів відеоінформаційного ресурсу для підвищення їх доступності. Побудовано метод для створення синтаксичного опису компактного уявлення сегментів. При цьому вони не впливають на втрату семантичної цілісності відеоресурсу. Метод включає наступні етапи обробки. Перший ‑ виключати кількість психовізуальної надмірності в часовому просторі на основі : виявлення областей допустимої корекції за локальним показником; округляти базові елементи області допустимої корекції до шести старших біт. Другий – усувати структурну надмірність на основі формування параметрів для опису області допустимої корекції.
Best Available Techniques Principle: International Treaties and Drafting in National Legislation
Authors: Tomažič Luka Martin 
Published: July 2023

Best available techniques (BAT) is a legal principle with origins in public international law. Through the activities of drafters at national levels, it finds its various expressions in the legal systems of individual states. This article will analyse the possible approaches to including the BAT principle in national legislation and the general guidelines that drafters should follow to achieve the desired effectiveness of legislation. International treaties are to be understood as partial drafting instructions. A case study will be made for the Slovenian legal system, where the expression of the BAT principle within the Slovenian national regulatory framework will be critically evaluated.
Povzetek. Najboljše razpoložljive tehnologije (BAT) so pravno načelo, ki izvira iz mednarodnega javnega prava. Z dejavnostmi pripravljavcev zakonodaje na nacionalnih ravneh je dobilo različne izraze v pravnih sistemih posameznih držav. V tem članku bodo analizirani možni pristopi k vključitvi načela BAT v nacionalno zakonodajo in splošne smernice, ki bi jih morali upoštevati pripravljavci zakonodaje, da bi dosegli želeno učinkovitost zakonodaje. Mednarodne pogodbe je treba razumeti kot delna navodila za pripravo besedil. Izdelana bo študija primera slovenskega pravnega sistema, kjer bo kritično ovrednoteno izražanje načela BAT v slovenskem nacionalnem zakonodajnem okviru.
Cornerstones for the Cross-border Attorney Service and the Importance of the EU-En4s Project and Partner Networking
Authors: Bores Lazo Jesús 
Published: July 2023

Many papers and contributions identify the processes by which consistent cross‐border service to the client may be achieved within globally integrated firms. The role of international attorneys is becoming very complex due to new global challenges. To surpass these obstacles, the principal solution is to cooperate and develop close collaboration with colleagues. This is why projects such as EU-En4s Diversity of Enforcement Titles in cross-border Debt Collection in EU, led by the University of Maribor, are so relevant.
Povzetek. Številni članki in prispevki opredeljujejo postopke, s katerimi je mogoče v globalno povezanih podjetjih doseči dosledno čezmejno storitev za stranko. Vloga mednarodnih odvetnikov postaja zaradi novih globalnih izzivov zelo zapletena. Za premagovanje teh ovir je glavna rešitev sodelovanje in razvijanje tesnega sodelovanja s kolegi. Zato so projekti, kot je EU-En4s Diversity of Enforcement Titles in cross-border Debt Collection in EU, ki ga vodi Univerza v Mariboru, tako pomembni.
La percepción sociolingüística en torno a las hablas locales urbano/rurales de la provincia de Melipilla
Authors: Céspedes Macarena , Martínez-Herrera Carolina , Poblete Mario 
Published: July 2023

La presente investigación sociolingüística tiene como objetivo principal rastrear diversas percepciones en torno a la variación entonativa de diferentes localidades en contextos rurales y urbanos en la provincia de Melipilla, Región Metropolitana. En la metodología, se incorporó un acercamiento etnográfico a las diferentes localidades, en las que se aplicó una encuesta de percepción a 87 sujetos, hombres y mujeres, de entre 18 y 70 años. En este artículo, se darán a conocer los resultados más relevantes en torno a las percepciones y autopercepciones acerca de usos específicos de estas comunidades y de su identidad hablada, entendiendo que dichas entidades se aproximan entre sí debido a la creciente urbanización de las localidades rurales cercanas a Santiago de Chile (Céspedes 2017).
KAJIAN SEMIOTIK JEAN BAUDRILLARD DALAM IKLAN TELEVISI NESTLE BEAR BRAND
Authors: Nararya Raden Roro Widya Dhana Kusuma , Laksana Rangga Cahyo Mukti 
Published: July 2023

Iklan sebagaimana yang disampaikan oleh Kotler harus dapat memuat pesan yang menarik perhatian, mempertahankan ketertarikan, membangkitkan keinginan, serta menggerakkan tindakan. Dalam hal ini, iklan televisi Nestle Bear Brand berusaha menyajikan pesan melalui tanda-tanda visual berupa naga putih yang masuk ke dalam kaleng susu beruang. Sebagai bagian dari masyarakat yang mengonsumsi tanda-tanda visual tersebut, penulis ingin mendapatkan kesimpulan akademis terkait absurditas kode dalam iklan televisi Nestle Bear Brand yang hingga kini masih menjadi perbincangan publik. Dengan mengkaji fenomena tersebut dalam perspektif semiotika Jean Baudrillard, penulis mendapati kesimpulan bahwasanya tidak ada kebenaran absolut dalam sebuah iklan, yang ada hanya simulasi. Absurditas kode yang diciptakan oleh iklan televisi Nestle Bear Brand adalah sebuah media dalam menyampaikan pesan. Sebagai produsen makanan dan minuman terbesar di dunia, Nestle Bear Brand ingin menciptakan realitas untuk produknya guna lebih menanamkan citra di benak audiens. Adapun makna dari tanda visual yang diciptakan adalah bagaimana produsen susu steril ini selalu menjaga kualitas produknya hingga khasiatnya tidak perlu diragukan lagi, terdepan dalam hal menjaga keseimbangan tubuh dari berbagai ancaman penyakit.
PERANCANGAN VIDEO ANIMASI 2D SEBAGAI MEDIA EDUKASI PEMBELAJARAN DARING DI MASA PANDEMI COVID-19
Authors: Soliha Mutia Putri , Pertiwi Elianna Gerda , Kalbuadi Gandung Anugrah 
Published: July 2023

Pandemi COVID-19 merupakan sebuah peristiwa yang telah menjadi sorotan dunia sejak tahun akhir 2019. Berbagai upaya juga serentak dilakukan oleh satu persatu negara diseluruh penjuru dunia agar meminimalisir perpindahan virus. Di Indonesia, pelaksanaan pembelajaran di semua jenjang pendidikan dilakukan secara daring. Dalam setiap jenjang pendidikan di Indonesia, sekolah dasar adalah salah satu tingkat pendidikan yang mengalami kendala belajar terbesar dalam pembelajaran daring. KBM secara daring ternyata memiliki berbagai persoalan yang dirasakan oleh siswa, guru, dan orang tua sebagai guru nomor dua atau pendampingan siswa belajar dirumah. Berdasarkan Penelitian oleh Agus Purwanto dkk., pada 3 pihak terdampak sekolah daring yang dilakukan pada wilayah provinsi Banten, kendala yang dirasakan siswa adalah Sulit mengerti materi yang diberikan secara daring, rindu teman, berkurang uang jajan, harus berbagi gawai dengan anggota keluarga dan distraksi lainnya. Orang tua juga memiliki kendala yakni harus mengeluarkan biaya kuota dan gawai, belum terlalu mengenal aplikasi belajar selain whatsapp, sulit membagi waktu untuk mengajari anak, dan lain sebagainya. Guru juga memiliki kendalanya sendiri seperti Siswa kurang rzesponsive dan antusias, terkadang tidak serius mengerjakan tugas, berpikir ekstra menyiapkan materi dan teknik penyampaian yang menarik, dan lain sebagainya. Oleh sebab itu, kemudian peneliti membuat sebuah perancangan yang berjudul “Perancangan Video Pendek Animasi 2D Sebagai Media Alternatif Edukasi “Fenomena Sekolah Dalam Jaringan Selama Masa Pandemi Covid-19 2020”.