bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alexander of Aphrodisias and the Active Intellect as Final Cause
Authors: Guyomarc’h Gweltaz 
Published: June 2023

Abstract
In his own De anima, Alexander of Aphrodisias famously identifies the “active” (poietikon) intellect with the prime mover in Metaphysics Λ. However, Alexander’s claim raises an issue: why would this divine intellect come in the middle of a study of soul in general and of human intellection in particular? As Paul Moraux asks in his pioneering work on Alexander’s conception of the intellect, is the active intellect a “useless addition”? In this paper, I try to answer this question by challenging a solution according to which the active intellect would intervene directly with the material intellect to trigger its ordinary working. I argue that the active intellect acts as a final cause, both for human intellect and for its ordinary objects of thought. The active intellect is twice “cause of the intellection”, i.e. cause of the actualization of human thought: once (i) when it offers thought occasions for thinking through objects, and again (ii) when it actualizes mediately the human intellect itself in its development. This reading agrees with Alexander’s usual position about the prime mover’s causality. It accounts for the multiplicity of expressions with which Alexander describes the causality of the active intellect in his De anima. It also explains why the development of human intellect has been described without direct reference to active intellect, since substances do not aim directly at the First cause, but their aiming at it is mediated by their desire for their own good.
L’articulation des chapitres 19 et 20 du traité VI, 2 [43] de Plotin. La priorité du genre sur ses espèces
Authors: Mouflier Camille 
Published: June 2023

Abstract
Chapter 20 of Plotinus’ treatise VI, 2 [43] has received particular attention because it seems to deal with the Intellect. However, the connection of this chapter with chapter 19 is problematic insofar as the latter deals with the ways in which species are generated by the first genera. Our aim will be to show that chapter 20 can only be understood in the light of the notion of genus. More precisely, Plotinus’ aim in this chapter is to demonstrate the priority of the genus over its species by means of the theory of double activity. In order to demonstrate this point, the notion of Intellect is introduced by Plotinus as a model (παράδειγμα) to conceive this priority. We will study successively these two chapters to justify this point, insisting on the link between them as well as on the reinterpretation of some key Aristotelian concepts. This study also shows that the use of the comparison with science allows Plotinus to justify the primacy of the intelligible totalities that are the Soul and the Intellect as well as the generation of their respective parts, the particular souls and the particular intellects.
Britain’s Failed Attempt at Monetary and Fiscal Exceptionalism
Authors: Marsh David 
Published: June 2023

Abstract
The autumn 2022 economic upheavals that brought down British Prime Minister Liz Truss’s government represented an ultimate extension of a high-risk exercise in British exceptionalism: the June 2016 referendum decision to leave the European Union. The ill-fated 23 September 2022 ‘mini budget’ introduced by Truss and Kwasi Kwarteng, her chancellor of the exchequer – like the referendum outcome six years earlier – was a landmark gesture of national independence. ‘The most ambitious and disastrous budget in modern British history’ illustrated how the intertwining forces of politics and economics set limits on ‘go it alone’ policies. The lessons reverberate beyond the UK’s borders.
Humor style predicts sarcasm use – evidence from Turkish speakers
Authors: Branowska Katarzyna , Kandemirci-Bayız Duygu , Abayhan Yasemin , Akdeniz Büşra , Banasik-Jemielniak Natalia 
Published: June 2023

Abstract
Humor and sarcasm are closely related – sarcasm is often identified with aggressive humor or humorous mockery. Research in this area is common in Western European languages, but not in non-WEIRD populations. The aim of the study was to examine the relationship between humor styles and sarcasm use in the Turkish-speaking population. We also attempted to predict the use of different sarcasm types (general sarcasm, embarrassment diffusion, face-saving, and frustration diffusion) by the scores of the Humor Styles Questionnaire (Martin, Rod A., Patricia Puhlik-Doris, Gwen Larsen, Jeanette Gray & Kelly Weir. 2003. Individual differences in uses of humor and their relation to psychological well-being: Development of the Humor Styles Questionnaire. Journal of Research in Personality 37(1). 48–75) scales (aggressive, affiliative, self-enhancing, and self-defeating humor). The data from 329 Turkish-speaking participants were collected: 250 women and 79 men (M
age = 37; SD = 12.32; age range: 18–70). Participants filled out online questionnaires including Sarcasm Self-Report Scale (Ivanko, Stacey L., Penny M. Pexman & Kara M. Olineck. 2004. How sarcastic are you? Individual differences and verbal irony. Journal of Language and Social Psychology 23(3). 244–271) adapted into Turkish, and the Humor Styles Questionnaire (Martin, Rod A., Patricia Puhlik-Doris, Gwen Larsen, Jeanette Gray & Kelly Weir. 2003. Individual differences in uses of humor and their relation to psychological well-being: Development of the Humor Styles Questionnaire. Journal of Research in Personality 37(1). 48–75) in Turkish adaptation (Tümkaya, Songül. 2011. Humor styles and socio-demographic variables as predictor of subjective well-being of Turkish university students. Egitim ve Bilim 36(160). 158–170). The results showed positive correlations between all humor styles and all sarcasm types, with the strongest correlation with aggressive humor. Regression analysis was used to find predictors of sarcasm use. Our results show that aggressive humor style is the main predictor of all self-reported sarcasm use scales.
Artificial Bee Colony algorithm in estimating kinetic parameters for yeast fermentation pathway
Authors: Ismail Ahmad Muhaimin , Remli Muhammad Akmal , Choon Yee Wen , Nasarudin Nurul Athirah , Ismail Nor-Syahidatul N. , Ismail Mohd Arfian , Mohamad Mohd Saberi 
Published: June 2023

Abstract
Analyzing metabolic pathways in systems biology requires accurate kinetic parameters that represent the simulated in vivo processes. Simulation of the fermentation pathway in the Saccharomyces cerevisiae kinetic model help saves much time in the optimization process. Fitting the simulated model into the experimental data is categorized under the parameter estimation problem. Parameter estimation is conducted to obtain the optimal values for parameters related to the fermentation process. This step is essential because insufficient identification of model parameters can cause erroneous conclusions. The kinetic parameters cannot be measured directly. Therefore, they must be estimated from the experimental data either in vitro or in vivo. Parameter estimation is a challenging task in the biological process due to the complexity and nonlinearity of the model. Therefore, we propose the Artificial Bee Colony algorithm (ABC) to estimate the parameters in the fermentation pathway of S. cerevisiae to obtain more accurate values. A metabolite with a total of six parameters is involved in this article. The experimental results show that ABC outperforms other estimation algorithms and gives more accurate kinetic parameter values for the simulated model. Most of the estimated kinetic parameter values obtained from the proposed algorithm are the closest to the experimental data.
Resonant inelastic tunneling using multiple metallic quantum wells
Authors: Zhang Yiyun , Lepage Dominic , Feng Yiming , Zhao Sihan , Chen Hongsheng , Qian Haoliang 
Published: June 2023

Abstract
Tunnel nanojunctions based on inelastic electron tunneling (IET) have been heralded as a breakthrough for ultra-fast integrated light sources. However, the majority of electrons tend to tunnel through a junction elastically, resulting in weak photon-emission power and limited efficiency, which have hindered their practical applications to date. Resonant tunneling has been proposed as a way to alleviate this limitation, but photon-emissions under resonant tunneling conditions have remained unsatisfactory for practical IET-based light sources due to the inherent contradiction between high photon-emission efficiency and power. In this work, we introduce a novel approach that leverages much stronger resonant tunneling enhancement achieved by multiple metallic quantum wells, which has enabled the internal quantum efficiency to reach ∼1 and photon-emission power to reach ∼0.8 µW/µm2. Furthermore, this method is applicable with different electronic lifetimes ranging from 10 fs to 100 fs simultaneously, bringing practical implementation of IET-based sources one step closer to reality.
Pan-cancer analysis, providing a reliable basis for IDO2 as a prognostic biomarker and target for immunotherapy
Authors: Mo Bangqian , Zhao Xiashuang , Wang Yongfeng , Jiang Xianglai , Liu Deming , Cai Hui 
Published: June 2023

Abstract

Objectives
Indoleamine 2,3-dioxygenase 2 (IDO2) is a homologous protein of the classical immune negative regulator Indoleamine 2,3-dioxygenase 1 (IDO1) that is indispensable in the metabolism of tryptophan and is closely related to the pathogenesis and progression of tumors. Nevertheless, the mechanism of IDO2 in malignant tumors is not fully understood warranting further research.

Methods
Data related to IDO2 in pan-cancer was obtained from The Cancer Genome Atlas (TCGA) database. Differences in IDO2 expression between pan-cancerous and corresponding normal tissues were analyzed, and survival rates were analyzed using Kaplan–Meier. The correlation between IDO2 expression and tumor-infiltrating immune cells (TIICs), tumor mutational load (TMB), microsatellite instability (MSI), mismatch repair (MMR), immune checkpoints (ICP) and DNA methyltransferase (DNMT) was investigated by Spearman correlation analysis. Functional enrichment analysis of IDO2 was performed to explore its biological and molecular roles in tumors.

Results
Our comprehensive pan-cancer analysis showed that IDO2 expression was significantly altered in most malignancies and correlated with poor prognosis. The expression of IDO2 was strongly associated with the progression of several tumors and excessive infiltration of immune cells in the tumor microenvironment (TME). The expression of IDO2 significantly correlated with TMB, MSI, MMR and ICP in different tumors. More importantly, functional enrichment analysis showed that IDO2 acts primarily through the regulation of antitumor immunological processes. RT-PCR validated IDO2 expression in multiple cancer cell lines, consistent with the bioinformatic analysis results.

Conclusions
IDO2 is closely related to tumor genesis and immunity, and can be used as an adjunct for the diagnosis and prognosis assessment of many tumors.
Differential expression and functions of miRNAs in bladder cancer
Authors: Huang Hao , Pi Xiaowu , Xin Chenqi , Gong Chen , Guo Feng , Wang Yang , Xiong Ying 
Published: June 2023

Abstract
Bladder cancer (BC), a urologic disease, commonly occurs globally and is very invasive. Patients with invasive BC have low 5-year survival rate. Hence, the mechanisms underlying BC development and progression should be elucidated. MicroRNAs (miRNAs), as common noncoding RNAs, are receiving increasing attention because of their biological functions. The irregular expression patterns of miRNAs are linked to BC occurrence; therefore, determining the functions of miRNAs in abnormally expressed BC tissues might enable to elucidate the pathogenetic mechanism of BC and offer new markers for the prognosis, diagnosis, and therapy of BC. Here, we consolidate the primary roles of miRNAs with atypical expression in BC development as well as their association with BC pathological grades and chemotherapy resistance development in patients with BC.
The inhibitory function of GDF11/BMP11 in liver cancer by inducing apoptosis and ROS–JNK pathway
Authors: Zhang Yonghui , Wang Chen , Li Jiaxin , Jin Lishan , Ding Wenxuan , Liu Huan , Zhou Na , Ren Zhengni , Zhang Junqi , Wei Yong , Li Lei , Pan Lianhong , Liu Dan 
Published: June 2023

Abstract

Objectives
The inhibitory mechanism of growth differentiation factor 11 (GDF11) on liver cancer cells is unknown. Our study applied RNA-Seq to investigate the transcriptome results of liver cancer cells after GDF11 treatment, revealing the underlying molecule mechanisms of the inhibitory roles of GDF11 on liver cancer cells.

Methods
First, mRNA and protein expression levels of GDF11 were detected through the Oncomine database and tissue microassay. In vitro, Smad2/3 signaling was checked using Western blot in liver cancer cell lines (MHCC97-H and HCCLM3) after GDF11 treatment. The growth effect of GDF11 on liver cancer cells was investigated by microscopic observation and the Cell Counting Kit-8 experiment. The underlying mechanisms were explored by transcriptome experiments, flow cytometry, electron microscopy, and Western blot.

Results
GDF11 was reduced in human malignant liver tissues and cell lines compared to normal liver tissues and cell lines. GDF11 activated Smad2/3 signaling and decreased cell viability in liver cancer cell lines (MHCC97-H and HCCLM3). RNA-Seq analysis found that 39 genes were significantly changed, 9 genes were significantly downregulated, and 30 genes were significantly upregulated. GDF11 could affect apoptosis and ROS, and JNK signaling.

Conclusions
GDF11 may have anti-liver cancer effects by affecting Smad2/3 and inducing apoptosis through the ROS-JNK pathway.
Rückführung dimensioneller Messungen an Großbauteilen für Windenergiesysteme
Authors: Kniel Karin , Heißelmann Daniel , Franke Matthias 
Published: June 2023

Zusammenfassung
Die hochgenaue und zuverlässige Messung von Großbauteilen für Windenergiesysteme auf Groß-Koordinatenmessgeräten (Groß-KMG) ist für deren störungsfreien Einsatz unter höchsten Belastungen unerlässlich. Um der Industrie auf diesem Gebiet Kalibrierungen auf höchstem Niveau sowie weitere messtechnische Unterstützung anbieten zu können, wurde in der Physikalisch-Technischen Bundesanstalt ein Groß-KMG etabliert. In diesem Beitrag werden die jüngsten Entwicklungen zu neuen Ansätzen für die Geometriefehlererfassung für große Messvolumina vorgestellt. Darüber hinaus gibt es Einblick in die Optimierungsstrategie für das neuartige Kalibrierverfahren M3D3 sowie in die Erweiterung des Virtuellen Koordinatenmessgerätes (VCMM) für die simulationsbasierte Messunsicherheitsbestimmung auf Groß-KMG.
Wittgenstein and Repetition
Authors: Arielli Emanuele 
Published: June 2023

Abstract
“I myself still find my way of philosophizing new, & it keeps striking me so afresh, & that is why I have to repeat myself so often. […] [R]epetitions […] [f]or me […] are necessary.” (CV 1998: 3e) Wittgenstein's style is well known for its recursive—and according to some interpreters, even obsessive-compulsive—quality, but they are part of a thinking method: “I suggest repetition as a means of surveying the connections.” (AWL 1979: 43) The style also mirrors recurring ideas such as “concepts are not for use on a single occasion” (Z 1981: 568), or the “bustle (Getriebe) of life […] comes about only through constant repetition” (RPP 1980b: 625 – 626).
The aim of this essay is to show how the notion of repetition (Wiederholung) plays a significant role in the evolution of Wittgenstein's thought. It is the manifestation of a philosophical praxis, and although the notion of repetition remains in the background, it is a constant presence in his production, often featuring alongside his best-known concepts, like rule following, aspect seeing, and his thoughts on music and mathematics. This article will examine the different ways in which Wittgenstein reflects on the question of repetition in relation to the idea of identity, variation, and diversity, and as a fundamental aspect of human practice that is not the mere manifestation of underlying rules or principles, but a necessary condition for their emergence.
Wahrheit in Wittgensteins Spätphilosophie
Authors: Forster Daniel 
Published: June 2023

Abstract

Truth in Wittgenstein′s Later Philosophy. In this paper I attempt to examine Wittgenstein′s understanding of truth in his later period. In doing so, I orient myself primarily on the remarks published as Philosophical Investigations and On Certainty. My primary aim in the destructive part is to show that his later philosophy neither espouses a redundancy and deflationary, nor an epistemic and anti-realist conception of truth. Both strands of interpretation are strongly represented in the debate. An examination of Wittgenstein’s remarks on the correspondence theory of truth will also shed some light on his thoughts about truth. Furthermore, in the preceding constructive part of this paper, I will try to demonstrate that (1) for Wittgenstein there is a strong link between truths that we accept based on our certainties and our use of the term “truth” and (2) that skepticism about truth, which claims that all accepted truths in our Weltbild (“world-view”) could be actually false, fails to give any meaning to its use of “truth”. This culminates in Wittgenstein′s insight, that the question of what truth is can only be answered relative to the Weltbild. Therefore, talking about truths that transcend our Weltbild becomes nonsense.
Wittgensteins Manuskriptbände aus dem Jahr 1929
Authors: Figueiredo Florian Franken 
Published: June 2023

Abstract

Wittgenstein's manuscript volumes from 1929: Reflections on the Chronology of MSS 105 – 107. In this paper I identify the evidence that might be used to establish a viable chronology for Wittgenstein’s writing of his manuscript volumes 105 – 107 and sections thereof. Since Wittgenstein omits to date his entries in these three 1929 volumes between February 15 and September 11, the evaluation of these different chronologies must remain somewhat speculative, but the justifications for each can, as I will show, be revealingly compared. I also argue that such attempts at a genealogical appreciation of Wittgenstein’s remarks is not only worthwhile on its own terms but it also further paves the way for an increased understanding of Wittgenstein’s philosophy. I articulate and evaluate three possible chronologies for the year 1929 and argue for the one I take to be the most plausible.
The Copyright Status of Wittgenstein’s Works
Authors: Lavazza Michele 
Published: June 2023

Abstract
Determining the copyright status of a literary work is not always straightforward, because copyrights are territorial and the relevant laws differ significantly country by country. In some legislations, for example, a work’s copyright status may depend on the publication date, on whether the publication was posthumous, on the quantity and quality of editorial interventions the manuscript underwent before publication, etc.
2021 marked the 70th anniversary of Wittgenstein’s death. In many countries, the duration of the copyright term is the author’s life plus 70 years. Thus, as of the moment of this writing, it is important to attempt a comprehensive analysis and to try to determine whether, where and why his manuscripts and his published works are in the public domain.
This paper clarifies the general principles of copyright and describes the rules and best practices that must be followed in the context of internet publications. Additionally, it examines the factors that make it particularly challenging to ascertain the copyright status both of Wittgenstein’s published works and of the transcriptions of his manuscripts. Lastly, it provides a detailed account of the copyright status of some of Wittgenstein’s works that were published in the second half of the 20th century, proving that they are in the public domain in most countries.
Wittgenstein’s Notebooks, Diaries and Diaristic Remarks
Authors: Somavilla Ilse 
Published: June 2023

Abstract
In my paper I will discuss the difference between Wittgenstein’s notebooks, personal diaries and his so called diaristic remarks scattered throughout the Nachlass. This includes a distinction between his philosophical and his diaristic entries. Secondly, I will outline the editing history of Wittgenstein’s Notebooks 1914 – 1916, his Secret Diaries (Geheime Tagebücher 1914 – 1916), Culture & Value and his diaries of the 1930s (Denkbewegungen).
Finally, I will focus on Wittgenstein’s coded remarks (in the wartime notebooks and in his diaristic remarks found in the Nachlass) and then discuss their significance not only in terms of his personal attitude toward life, ethics and religion but also in terms of their role in the context of his philosophizing. In doing so, I will discuss the question of the extent to which Wittgenstein’s method of encoding can be seen as a means for a special type of text, conceived for a sphere not readily accessible to normal language and science – a sphere he avoided talking about in the context of strict philosophical dispute.
New Philosophical Aspects and the Philological Questions Emerging by Exploring the Digital Edition of Wittgenstein’s Nachlass
Authors: De Iaco Moira 
Published: June 2023

Abstract
The main goals of this paper are to highlight the new philosophical aspects emerging from Wittgenstein’s Nachlass and to analyze some of the philological questions that should be considered by editors and translators of Wittgenstein’s writings and by scholars of Wittgenstein’s philosophy. There are undoubtedly advantages to be had from exploring Wittgenstein’s Nachlass and this contribution will be focused on them. However, there are also some critical issues to be taken into account. They concern Wittgenstein’s way of writing and doing philosophy as well as the status of Wittgenstein’s manuscripts and the history of their publication. The advantages of investigating Wittgenstein’s movements of thought through and across the Nachlass and the resulting critical issues will be argued from the perspective of direct work editing Wittgenstein (e. g., the edition of two discovered letters of 1934 from Wittgenstein to Sraffa) and through the semantic reconstruction of crucial concepts from Wittgenstein’s philosophy. This reconstruction has been realized by the searching of Wittgenstein’s concepts occurrences and the recording and exploration of the nuances of meaning represented by each occurrence within the project to compose a Wittgenstein dictionary from the Nachlass.
A temática ambiental no currículo de ciências da natureza: uma revisão dos anais do ENPEC de 2013 e 2015
Authors: Nogueira Liliane Samira Becari 
Published: June 2023

Este artigo comunica uma revisão bibliográfica cujoobjetivo foi analisar aspectos relacionados à inserção da temática ambiental nos currículos de Ciências da Natureza, da educação básica, evidenciados pelos trabalhos publicados nos anais do Encontro Nacional de Pesquisa em Ensino de Ciências (ENPEC), nos anos de 2013 e 2015. A análise foi estruturada em três categorias, a saber: “Concepções de currículo”, “Educação Ambiental (EA) e interdisciplinaridade” e “Possibilidades pedagógicas para a inserção da temática ambiental nos currículos”. A maioria dos trabalhos traz a interdisciplinaridade como a principal perspectiva de abordagem para as questões ambientais. A ausência de trabalhos que analisem a inserção da temática ambiental nas propostas curriculares brasileiras foi uma lacuna encontrada, uma vez que as Diretrizes Curriculares Nacionais para a Educação Ambiental (DCNEA) orientam o trabalho com a EA, em todos/as os níveis/modalidades de ensino, por um viés crítico e transformador.