bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Improved Model for Evaluating the Hydraulic Behaviour of a Single Rock Joint Considering Contact Area Evolution During Shearing
Authors: Zhu X. , Gao M. , Si G. , Zhang C. , Moon J.-S. , Oh J. 
Published: September 2023

AbstractThe contact of rock joints during shearing induced by underground excavation significantly impacts the hydro-mechanical behaviour of fractured rock mass, since fluid tends to flow through a rough-walled fracture along connected channels while bypassing the contact areas with tortuosity. However, previous research mostly considered joint roughness or aperture changes based on 2D joint profiles, while the contact and tortuosity using 3D surfaces were often overlooked. This paper considers the evolution of contact area and aperture distribution during shearing. The concept of the critical inclination angle is introduced and correlated with the contact area during shearing based on Grasselli’s criterion. The standard deviation of the mean mechanical aperture is calculated using the modified algorithm. An improved model for estimating the hydraulic aperture with the mechanical aperture is then developed, applying an aperture correction term and a contact correction term. A number of shear-flow tests on artificial joint samples under constant normal loads are conducted. The accuracy and reliability of the proposed model are verified by comparing it against the experimental results and by comparing the prediction performance with other published models. Results show that the proposed model can improve the prediction of the hydraulic aperture and hydraulic conductivity of a single rock joint during shearing.
The clinical course and outcomes of non-aneurysmal subarachnoid hemorrhages in a single-center retrospective study
Authors: Tarkiainen Jeremias , Hovi Valtteri , Pyysalo Liisa , Ronkainen Antti , Frösen Juhana 
Published: September 2023

Abstract
Background
Non-aneurysmal subarachnoid hemorrhages (SAHs) are thought to have a benign clinical course compared to aneurysmal SAHs. The aim of this study is to report the clinical course and outcomes of non-aneurysmal SAHs in a large single-center study.

Methods
The patients with non-aneurysmal SAHs were screened from Tampere University Hospital from 2005 to 2020. The clinical data were collected from the patient’s medical records and from the imaging studies. The primary interest was the neurological outcome assessed by dichotomized GOS at 2 months. Multivariable logistic regression was used to study the factors associated with unfavorable outcome.

Results
We found 216 non-aneurysmal SAHs in 214 patients (2 patients with > 1 bleed). Ninety-seven percent of patients with a typical perimesencephalic bleeding pattern SAH (PSAH) (75/77) had a favorable outcome, while 86% of patients with non-perimesencephalic SAH (NPSAH) had a favorable outcome (84/98). In a multivariable logistic regression analysis, loss of consciousness (LOC) (aOR 214.67, 95% CI 17.62–2615.89) and Fisher grade 4 bleeding pattern (aOR 23.32, 95% CI 1.40–387.98) were associated with increased risk for unfavorable outcome (GOS 1–3). Vasospasm was seen in 20% of non-aneurysmal SAH patients, hydrocephalus in 17%, and 13% needed ventriculostomy.

Conclusions
Non-aneurysmal SAH seems to have a good prognosis for majority of patients, especially for patients with a PSAH. Non-aneurysmal SAH patients are however affected by vasospasm and hydrocephalus and have similar risk factors for poor outcome as patients with aneurysmal SAH. This suggests that it is the severity of the bleed rather than the etiology that associates with poor outcome.
Novelties for increased safety in cranio-vertebral surgery: a review
Authors: Tessitore Enrico , Mastantuoni Ciro , Cabrilo Ivan , Schonauer Claudio 
Published: September 2023

AbstractThe cranio-vertebral junction (CVJ) was formerly considered a surgical “no man’s land” due to its complex anatomical and biomechanical features. Surgical approaches and hardware instrumentation have had to be tailored in order to achieve successful outcomes. Nowadays, thanks to the ongoing development of new technologies and surgical techniques, CVJ surgery has come to be widely performed in many spine centers. Accordingly, there is a drive to explore novel solutions and technological nuances that make CVJ surgery safer, faster, and more precise. Improved outcome in CVJ surgery has been achieved thanks to increased safety allowing for reduction in complication rates. The Authors present the latest technological advancements in CVJ surgery in terms of imaging, biomaterials, navigation, robotics, customized implants, 3D-printed technology, video-assisted approaches and neuromonitoring.
Constitutive modeling of orthotropic nonlinear mechanical behavior of hardened 3D printed concrete
Authors: Mader Thomas , Schreter-Fleischhacker Magdalena , Shkundalova Olena , Neuner Matthias , Hofstetter Günter 
Published: September 2023

Abstract3D printing of concrete is a promising construction technology, offering the potential to build geometrically complex structures without the use of cost-intensive formwork. The layer-wise deposit of filaments during the 3D printing process results in an intrinsic orthotropic mechanical behavior in the hardened state. Beyond that, the material behavior of 3D printed concrete (3DPC) is governed by a highly nonlinear behavior, characterized by irreversible deformations, strain hardening, strain softening and a degradation of the material stiffness. In this contribution, a new constitutive model for describing the orthotropic and highly nonlinear material behavior of 3DPC will be presented. It is formulated by the extension of a well-established isotropic damage plasticity model for concrete to orthotropic material behavior by linear mapping of the stress tensor into a fictitious isotropic configuration. The performance of the new model will be evaluated by finite element simulations of three-point bending tests of 3DPC samples, performed for different orientations of the loading direction relative to the printing direction and comparison with experimental results. In addition, the applicability of the model to replicate the mechanical behavior of 3DPC, manufactured by the alternative 3D printing process of binder jetting of cementitious powders, will be demonstrated by 3D finite element simulations of an arch structure with varying orientations of the loading direction relative to the layering. Overall, the proposed model provides a computationally efficient modeling approach for large-scale finite element simulations of 3DPC structures, being a promising alternative to complex and computationally expensive finite element models considering distinct interfacial planes.
Pregnancy, fertile life factors, and associated clinical course in PRKN early-onset Parkinson’s disease
Authors: Bovenzi Roberta , Conti Matteo , Degoli Giulia Rebecca , Cerroni Rocco , Artusi Carlo Alberto , Pierantozzi Mariangela , Stefani Alessandro , Mercuri Nicola Biagio , Schirinzi Tommaso 
Published: September 2023

Abstract
Introduction
As the most common cause of autosomal recessive early onset Parkinson’s disease (EOPD), parkin type Parkinson’s disease (PRKN-PD) may affect female patients in childbearing age. Accordingly, issues related to fertility must be adequately addressed. Here, we landscaped fertile life factors and pregnancy course of a PRKN-PD cohort, including both novel cases directly observed at our center and published ones.

Methods
Six patients with confirmed PRKN-PD were examined by a structured interview on reproductive factors and associated modifications of PD disturbances, including one case followed up throughout pregnancy which was described in greater detail. Six studies reporting fertile life factors of nine PRKN-PD patients were reviewed collecting homogeneous data on fertile life and pregnancy course.

Results
PRKN-PD female patients experienced motor fluctuations with the menstrual cycle, pregnancy, and puerperium, which suggests a role for sex hormones in PD clinical burden. In some cases, abortion and miscarriages occurred during the organogenesis phase in patients receiving oral antiparkinsonian therapy; however, levodopa/benserazide monotherapy resulted to be the safest choice in pregnancy.

Conclusion
Collectively these data disclose the importance of pre-conception counseling in childbearing age PRKN-PD patients and EOPD in general.
A template-based approach for question answering over knowledge bases
Authors: Formica Anna , Mele Ida , Taglino Francesco 
Published: September 2023

AbstractIn this paper, we address the problem of answering complex questions formulated by users in natural language. Since traditional information retrieval systems are not suitable for complex questions, these questions are usually run over knowledge bases, such as Wikidata or DBpedia. We propose a semi-automatic approach for transforming a natural language question into a SPARQL query that can be easily processed over a knowledge base. The approach applies classification techniques to associate a natural language question with a proper query template from a set of predefined templates. The nature of our approach is semi-automatic as the query templates are manually written by human assessors, who are the experts of the knowledge bases, whereas the classification and query processing steps are completely automatic. Our experiments on the large-scale CSQA dataset for question-answering corroborate the effectiveness of our approach.
CLASRP oncogene as a novel target for colorectal cancer
Authors: Gu Quan , Wu Jianzhong , Xu Heng , Cao Haixia , Zhang Junying , Jing Changwen , Wang Zhuo , Du Mengjie , Ma Rong , Feng Jifeng 
Published: September 2023

AbstractClk4-associated serine/arginine-rich protein (CLASRP), an alternative splicing regulator, may be involved in the development and progression of cancer by regulating the activity of the CDC-like kinase (Clk) family. This study explored the biological function of CLASRP in colorectal cancer (CRC). The expression of CLASRP, which is associated with clinicopathological features, was analysed in CRC tissues and paired noncancer tissues by RT–PCR. The roles of CLASRP were investigated in CRC cells transfected with plasmids or shRNA through proliferation, migration and invasion assays in vitro and a xenograft model in vivo. Apoptosis was analysed using CLASRP-overexpressing CRC cells by western blotting. Clk inhibitors were used to perform functional research on CLASRP in CLASRP-overexpressing CRC cells. CLASRP was significantly upregulated in CRC cell lines, while high CLASRP expression was correlated with metastasis in CRC patients. Functionally, overexpression of CLASRP significantly promoted the proliferation, migration and invasion of CRC cells in vitro and tumour growth in vivo. Mechanistically, the proliferation, migration and invasion of CLASRP-overexpressing CRC cells were inhibited by Clk inhibitors, accompanied by low expression of CLASRP at the gene and protein levels. Clk inhibitors induced apoptosis of CLASRP-overexpressing CRC cells, resulting in direct blockade of cell growth. The expression levels of cleaved caspase 3 and cleaved caspase 8 were increased in CLASRP-overexpressing CRC cells treated with Clk inhibitors. CLASRP might serve as a promotional oncogene in CRC cells and be suppressed by Clk inhibitors through activation of caspase pathways.
Evaluation of cardiovascular autonomic dysfunction in symptomatic post-COVID-19 patients using the heart rate variability (HRV) and detection of subtle LV dysfunction using 2D global longitudinal strain (GLS)
Authors: Nour Amira , Fouad Mirna , Salam Zeinab Abdel 
Published: September 2023

Abstract
Aim
The COVID-19 disease primarily affects the respiratory system; however, cardiac involvement has been documented in the acute phase. We aimed to evaluate the cardiac autonomic function and subtle left ventricular dysfunction in those subjects recovered from mild to moderate acute COVID-19 patients but still symptomatic.

Methods and results
The study group was composed of 50 subjects with confirmed mild to moderate COVID-19. All subjects underwent routine 2D echocardiography assessment in addition to 2D speckle tracking and 24 h Holter monitoring for HRV analysis. The mean age of the study population was 42 ± 18 years; symptoms were reported as follows 27 (54%) had dyspnoea, 17 (34%) had palpitation, and 7 (14%) had dizziness. Time domain parameters Standard Deviation of NN intervals (SDNN), Standard Deviation of the Average NN intervals for each 5 min segment of a 24 h HRV recording (SDANN), and Root Mean Square of Successive RR interval Differences (rMSSD) were diminished with mean SDNN value being markedly impaired in 12 (24%) patients, while frequency domain parameters as assessed by the ratio of the Low-Frequency band power to the High-Frequency band power (LF/HF) with the mean of 1.837 with 8% of the patients being impaired. SDNN was significantly reduced in patients with impaired global longitudinal strain (p 0.000). The global longitudinal strain was diminished in 10 patients (20%); also, 80% of the patients with impaired GLS had decreased SDNN.

Conclusion
Our study targeted patients experiencing prolonged symptoms after COVID-19 illness. We detected a high incidence of GLS impairment using Speckle Tracking Echocardiography (STE) and a significant prevalence of diminished HRV. HRV (especially SDNN) and GLS were found to be significantly correlated.

Graphical abstract
Epigenetic control of pancreatic cancer metastasis
Authors: Krauß Lukas , Schneider Carolin , Hessmann Elisabeth , Saur Dieter , Schneider Günter 
Published: September 2023

AbstractSurgical resection, when combined with chemotherapy, has been shown to significantly improve the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC). However, this treatment option is only feasible for a fraction of patients, as more than 50% of cases are diagnosed with metastasis. The multifaceted process of metastasis is still not fully understood, but recent data suggest that transcriptional and epigenetic plasticity play significant roles. Interfering with epigenetic reprogramming can potentially control the adaptive processes responsible for metastatic progression and therapy resistance, thereby enhancing treatment responses and preventing recurrence. This review will focus on the relevance of histone-modifying enzymes in pancreatic cancer, specifically on their impact on the metastatic cascade. Additionally, it will also provide a brief update on the current clinical developments in epigenetic therapies.
Viscose nonwoven fabric with copper and its multifunctional properties
Authors: Cieślak Małgorzata , Kowalczyk Dorota , Baranowska-Korczyc Anna , Kamińska Irena , Krzyżowska Małgorzata , Janicka Martyna , Kubacki Jerzy 
Published: September 2023

AbstractThe antimicrobial functionalization of textile structures with copper and its compounds carried out by various methods increased significantly during the SARS-CoV-2 pandemic. So far, in order to obtain antiviral properties the magnetron technique using copper was applied mainly to flat textile structures; polypropylene, polyester and cotton nonwovens, and polyester and cotton woven fabrics. In this study, magnetron sputtering with copper was applied to modify the spatial viscose needle-punched nonwoven fabric. We found that the spatial nonwoven structure made of regenerated cellulose fibers and one-side sputtered with copper has strong antimicrobial activity against Gram-positive Staphylococcus aureus and Gram-negative Klebsiella pneumoniae. In the case of herpes simplex virus type 1 (HSV-1) McKrae strain, vaccinia virus (VACV) WR strain, influenza A virus H1N1 (IFV) and mouse coronavirus (MHV) JHV strain used in the study, Cu modified nonwoven fabric has only weak activity against herpes simplex virus type 1 (HSV-1). It also has no significant toxicity compared to the control medium and pristine nonwoven fabric. The modified nonwoven fabric is characterized also by hydrophobic properties, high electrical conductivity, good air and water vapor permeability, and meets the requirements of breathing resistance for all protection classes (FFP1, FFP2 and FFP3) specified in the EN 149-2001 standard.
Meiotic segregation and post-meiotic drive of the Festuca pratensis B chromosome
Authors: Ebrahimzadegan Rahman , Fuchs Jörg , Chen Jianyong , Schubert Veit , Meister Armin , Houben Andreas , Mirzaghaderi Ghader 
Published: September 2023

AbstractIn many species, the transmission of B chromosomes (Bs) does not follow the Mendelian laws of equal segregation and independent assortment. This deviation results in transmission rates of Bs higher than 0.5, a process known as “chromosome drive”. Here, we studied the behavior of the 103 Mbp-large B chromosome of Festuca pratensis during all meiotic and mitotic stages of microsporogenesis. Mostly, the B chromosome of F. pratensis segregates during meiosis like standard A chromosomes (As). In some cases, the B passes through meiosis in a non-Mendelian segregation leading to their accumulation already in meiosis. However, a true drive of the B happens during the first pollen mitosis, by which the B preferentially migrates to the generative nucleus. During second pollen mitosis, B divides equally between the two sperms. Despite some differences in the frequency of drive between individuals with different numbers of Bs, at least 82% of drive was observed. Flow cytometry-based quantification of B-containing sperm nuclei agrees with the FISH data.
Wordless Picturebooks as Resources for the Construction of the Pedagogy of Multiliteracies. The Case of Migrants, by Issa Watanabe
Authors: Pereira Íris Susana Pires , Gil Maitê , Bunzen Clecio 
Published: September 2023

Abstract
This article presents the study of Migrants (2019), a wordless picturebook by Peruvian author Issa Watanabe, developed to answer the following research question: To what extent can this visual text become a resource for the learning of multiliteracies? A visual discourse analysis of the narrative was performed, focusing on the identification of key meanings and semiotic resources used in their visual construction. Our findings unveil the prominent role of semiotic resources such as anthropomorphism, vectors, colours, position and unboundedness of the page frame, in the visual realization of key meanings such as diversity, journeys, death, and empathy. Upon these findings, we present Migrants as an extraordinary literary text to initiate children in learning the visual mode, one of the multiple modes currently used in the representation of meaning. We discuss our findings with reference to the main question leading the study, the pedagogical conceptualizations endorsed by the multiliteracies theoretical framework and other relevant research. While the study suggests that wordless picturebooks are called to play a prominent role in the construction of the multiliteracies pedagogical agenda, it furthermore points to the potential of the pedagogy of multiliteracies in the conceptualization of literary pedagogy itself.
Opinion Dynamics with Preference Matching: How the Desire to Meet Facilitates Opinion Exchange
Authors: Steinbacher Mitja , Steinbacher Matjaž , Knoppe Clemens 
Published: September 2023

AbstractThe paper reexamines an agent-based model of opinion formation under bounded confidence with heterogeneous agents. The paper is novel in that it extends the standard model of opinion dynamics with the assumption that interacting agents share the desire to exchange opinion. In particular, the interaction between agents in the paper is modeled via a dynamic preferential-matching process wherein agents reveal their preferences to meet according to three features: coherence, opinion difference, and agents’ positive sentiments towards others. Only preferred matches meet and exchange opinion. Through an extensive series of simulation treatments, it follows that the presence of sentiments, on one hand, hardens the matching process between agents, which leads to less communication. But, on the other hand, it increases the diversity in preferred matches between agents and thereby leads to a better-integrated social network structure, which reflects in a reduction of the opinion variance between agents. Moreover, at combinations of (a) high tolerance, (b) low sensitivity of agents to opinion volatility, and (c) low levels of confidence, agents are occasionally drawn away from the consensus, forming small groups that hold extreme opinions.
Potential to use metaverse for future teaching and learning
Authors: Onu Peter , Pradhan Anup , Mbohwa Charles 
Published: September 2023

AbstractMetaverse, a virtual shared space integrating augmented reality and virtual reality technologies, is often hailed as the “Internet of the future” for its potential to revolutionize online communication, collaboration, learning, and work. However, despite its promising strategic and business applications, there is a dearth of empirical evidence for evaluating its educational value. This qualitative study examined the impact of Metaverse on teaching and learning by examining its advantages and challenges. The outcomes highlight Metaverse’s remarkable potential for personalized and adaptive learning thanks to its immersive and interactive capabilities. An analysis of the existing literature suggests that Metaverse can create engaging learning experiences in which students can explore tailored virtual environments and interact within them. Semi-structured in-depth interviews were conducted to confirm the perception of metaverse-based education among students, educators, and program administrators, who view it as an innovative and effective educational delivery method. Several barriers require attention to ensure the successful integration of Metaverse in education, such as network connectivity, reliability, standardization and certification, organizational readiness, and the specialized skills necessary to leverage Metaverse’s potential. This study offers a comprehensive understanding of Metaverse’s potential, limitations, and critical factors contributing to its education success. By providing immersive and interactive learning experiences tailored to individual student needs, Metaverse holds the power to revolutionize teaching and learning. However, addressing challenges related to interoperability and the need for more evidence on its efficacy requires further research and development efforts. The significance of this study hinges on the continued exploration of Metaverse to enhance educational experiences, offering a novel and innovative approach to teaching and learning.
The Reversibility Paradox: Role of the Velocity Reversal Step
Authors: Binder P.M. 
Published: September 2023

AbstractThe reversibility, or Loschmidt paradox, is a thought experiment in which microscopic reversibility is exploited to generate an apparently spontaneous trajectory in which entropy decreases, thus violating the Second Law of Thermodynamics (SLT). To achieve this, the system is allowed to evolve from a low-entropy to a high-entropy configuration, at which point all velocities of its molecules are reversed, thus producing the desired effect. In this paper we focus on the velocity reversal step. Implementing this step requires the measurement of velocities and positions, which must be stored in a memory. Even in the case of a reversible measurement, the erasure of the stored information, necessary to reset the measuring device to its original state, has an entropy cost that offsets the entropy decrease during the reverse evolution of the system. This cost is sufficient to explain why the described procedure does not violate the SLT.