bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Tpeak-Tend Interval as an Arrhythmogenicity Index in Graves' Disease
Authors: Kirac Cem Onur , Sirikci Vehbi , Findikli Huseyin Avni 
Published: May 2023

Introduction.Graves’ disease is the most common cause of hyperthyroidism. The mortality rate increases by 20% in hyperthyroid patients; cardiac problems are the leading cause of death and arrhythmia is the most common cardiac complication.
Our study aimed to evaluate the corrected QT interval (QTc), the Tpeak-Tend interval (Tp-e), and the Tp-e/QTc ratio to predict arrhythmia risk in patients with Graves’ disease.
Methods. The study included 64 patients with Graves’ disease and 57 euthyroid controls. The 12-lead electrocardiograms of the individuals under study were evaluated. The QTc interval, the Tp-e interval, and the Tp-e/QTc ratio of all participants were determined and statistically evaluated with thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) values.
Results. Tp-e (p < 0.001) and QTc (p < 0.05) were significantly prolonged in the group of patients with Graves’ disease as compared to the control group. Heart rate was higher in patients with Graves’ disease as well (p < 0.05). Correlation analysis in patients with hyperthyroidism demonstrated that Tp-e (r=0.372, p=0.002), QTc (r=0.291, p=0.020), and fT3 levels were significantly and positively correlated. Similarly, Tp-e (r=0.271, p=0.030), QTc (r=0.259, p=0.039), and fT4 levels were significantly and positively correlated.
Conclusions. We observed a significant prolongation of the Tp-e and QTc intervals with the increase in fT3 and fT4 levels. On the other hand, our study demonstrated that the sensitivity and specificity of Tp-e in the prediction of hyperthyroidism were 70.3% and 70.1%, respectively (AUC=0.724 (CI: 0.629-0.818)), the optimal cut-off value=83.5 ms). The Tp-e interval, which has recently been used as one of the arrhythmogenicity indices, may be an indicator of arrhythmia risk in patients with Graves’ disease.
Turkish Dental Students’ Perceptions and Awareness of Dental Implant Education: A Questionnaire Study
Authors: Izgi Eda , Mollaoglu Nur 
Published: May 2023

Objective. This study aimed to assess Turkish dental students’ awareness of and attitudes toward dental implant therapy, as well as the effectiveness of dental implantology lecture from their point of view.
Materials and Methods. This study used a cross-sectional online survey. A total of 425 third-, fourth- and fifth-year dental students enrolled in Gazi University School of Dentistry during the 2020-2021 academic year were invited to participate in the survey anonymously and voluntarily. Following the descriptive part (age, gender, and education status), all the participants were asked 11 questions.
Results. Total of 415 questionnaires were analyzed. The 3rd-year students stated that they were“ poorly” informed about dental implants (n=88, 64.7%), while the 4th- and 5th-year students were“ moderately” infromed (n=78, 54.2% and n=60, 44.4%, respectively) (p < 0.001). All the students were believed that they needed to get more information during their undergraduate studies (p < 0.01). More than half of all students preferred to have PhD or speciality training after graduation (p > 0.05). Approximately 80% of all students believed that dentists should receive specialized training in order to practice implant dentistry (p > 0.05).
Conclusions. The results of this study show that some Turkish dental students find DI treatment a difficult operation and that they do not know enough about it. As a result, it is anticipated that improving the current curriculum will contribute to the course success and make dental students feel better prepared for dental implantology following graduation.
“MedEd” on Twitter: A Social Network Analysis
Authors: Iqbal Shazia , Ahmad Shahzad , Samsudin Mohd Ali , Lodhi Saood Khan , Manji Salima Naveed 
Published: May 2023

Background. In the current era, Twitter is an increasingly popular tool for the dissemination of information as a social media voice. Social media is a valid, but underutilized, education tool at medical education institutions. Social media technologies provide opportunities for the presentation of information in alternative and multiple formats to enhance engagement, content creation, and motivation for individual and collaborative learning.
Objective. This study examined the type of social structure and sub-clusters do exist regarding “MedEd” on the Twitter network. Additionally, it determined the top opinion leaders in these networks and which type of topics generates users’ interest regarding “MedEd”.
Methods. This study applied NodeXL to analyze the results and retrieved Twitter data on November 1, 2022 by using the keywords “MedEd”. The data were saved and interpreted in the “vertices” and “edges” on the NodeXL worksheets.
Results. We found that the top opinion leader (vertex) “Cryptovitas” had the highest in- betweenness and out-degree centrality. “Innov_medicine” had the in-degree centrality for networks. “In-Degree” and “Out-Degree” are the count of Tweets an opinion leader gets and forwards messages out, correspondingly. The study found that although “Cryptovitas” had the highest in-betweenness centrality, “taylorswift13” had the maximum number of followers (91,523,045) with in-betweenness centrality of 0.0. This indicates that the vertex having maximum influence with the largest number of in-betweenness centrality has not linked with several followers.
Conclusions. Using Twitter embodies a potential prospect to engage the medical education community. The content of top networks’ tweets was around the number of “MedEd” innovations with the potential to significantly improve medical education delivery and innovative technologies in healthcare services. There is no link between the number of followers and in-betweenness centrality to influence the strength of social media voice. Although clinical and social tweets were there, not much was discussed regarding the curriculum reforms, continued professional development, technical issues in MedEd, and assessments. This triggers the insistence for rapid and innovative adaptations to the new learning environments and remarkable revolutions in medical education, including the encouragement of evidence-based education. The Twitter discussions promoted a research network circulating a wide range of informative innovations and collaborations.
Qualitative and Quantitative Determination of Secondary Metabolites of Sphaeranthus indicus and Spathodea campanulata Flowers Extracts
Authors: Chauhan Madhvi Singh , Yadav Swati 
Published: May 2023

Since the dawn of time, humans have used plants as a natural source for healing and remedies. Among these, medicinal herbs have gained popularity due to their widespread use and lack of negative side effects. The globe has seen a rise in plant study in recent years, and a tonne of data has been gathered to demonstrate the enormous potential of the therapeutic plants employed in many traditional systems. In this work, flower extracts of Sphaeranthus indicus and Spathodea campanulata from the Madhya Pradesh region of Bhopal were evaluated for their qualitative and quantitative phytochemical composition. The well-known test procedure described in the literature was used to determine the quantitative analysis of total phenolics and flavonoids as well as the qualitative analysis of various phytochemical constituents. Sphaeranthus indicus and Spathodea campanulata both included alkaloids, carbohydrates, saponins, fixed oils and lipids, flavonoids, and phenolics, according to phytochemical analyses. By using the Folins Ciocalteau reagent method and the aluminium chloride method, respectively, phenolic and flavonoid quantities were analysed quantitatively. The amount of total phenolics in the methanolic extract of the flowers of Sphaeranthus indicus and Spathodea campanulata was 18.23±0.16 and 217.00±0.916mg/gm, respectively. Flavonoids came in second with 164.10±0.52 and 79.33±3.511mg/gm. This research gave information that might be used to standardize and correctly identify this plant material. The wide range of phytochemicals found in the plant thus points to its medicinal potentials, which could be investigated in both traditional medicine and the drug manufacturing business.
Keywords: Sphaeranthus indicus, Spathodea campanulata, Qualitative analysis, quantitative analysis, Phytochemical analysis
Formulation and Evaluation of Sustained Release Tablet of Metformin by Ionic Gelation Technique using Sida acuta Gum as Release Retardant
Authors: Okafo Sinodukoo Eziuzo , Monioro Phillips Oghenerhivwe , Enyaosah Perpetual Ogochukwu , Offor Amarachi 
Published: May 2023

This research was done to formulate and assess the sustained release property of metformin tablets prepared from metformin microcapsules produced by ionic gelation technique using Sida acuta gum or sodium carboxymethylcellulose as release retardant. Sida acuta gum was produced by isopropyl alcohol precipitation of the filtrate obtained from distilled water maceration of powdered dried Sida acuta leaves. Metformin and Sida acuta gum compatibility was determined using FTIR. Metformin microcapsules were prepared by ionic gelation technique using sodium alginate alone or with either Sida acuta gum or sodium carboxymethylcellulose as release retardant. The microcapsules were evaluated for % yield and flow properties. The size and surface morphology of the microcapsules were determined using scanning electron microscopy. Metformin tablets were prepared from the microcapsules using direct compression technique. The tablets were evaluated for hardness, friability and in vitro dissolution. There was no major incompatibility between metformin and Sida acuta gum. The microcapsules have excellent flow property and were of micrometer size range. They have rough surfaces. The friability of the tablets ranged from 0.4-1.6% while the hardness was from 3.82-11.17 Kgf. The tablets from formulations M2 failed both friability and hardness test. About 44.5-47.1% of metformin was released from the tablet formulations after 6 h while 86.0-100% was released after 10 h. All the tablet formulations showed sustained release ability.
Keywords: Microcapsules, metformin, Sida acuta gum, sustained release, ionic gelation
Formulation, Evaluation and Antibacterial Effect of Herbal Toothpaste using leaves and flowers Acmella ciliata
Authors: Nirmala Devi N , Rasmi R , Aparna K , Gokul K V , Kavya K , Lanina T 
Published: May 2023

Oral hygiene, an integral part of the body’s general well-being, it is the practice of keeping the mouth clean and disease free by using tooth paste, mouth wash etc. Plants have been a great source of medical agents for many years and even be considered the origin of modern medicine. Phytochemicals the secondary metabolites of the plants are active ingredients that possess therapeutic properties that are considered as a medicine or drug for therapeutic purposes for the curing of diseases and improving human health. The main objective of this study is to formulate and develop an herbal toothpaste from herbal source and to evaluate its antibacterial activity. The herbal toothpaste containing leaves and flowers of Acmella ciliate, clove, honey and leaves of guava as the herbal ingredients. Different types of formulations (F1-F3) were formulated using Calcium carbonate as cleaning and polishing agent, Glycerine as humectant, Sodium lauryl sulphate, Sodium chloride as a stain remover from the teeth, Honey. The three formulations were evaluated by various parameters like colour, taste, fragrance, consistency, pH, shape maintenance, threading property, moisture content and foaming character. The herbal toothpaste having aqueous extract of herbal source are tested for antibacterial activity against K. pneumoniae, S. aureus, P. aeruginosa and S. pyogenes. The result shows that the bacteria were found to be more sensitive to the formulated toothpaste as seen by zone of inhibition. Further studies would benefit from a uniform method of assessment for clinical effectiveness of plaque and gingivitis and safety of the formulated herbal toothpaste.
Keywords: Phytochemicals,Acmella ciliate,herbal toothpast, antibacterial activity
Approaches to Improve Oral Bioavailability of Antihypertensive Drugs: A Mini-Review
Authors: Dole Radhika , Kothapally Daniel , Chukkala Sampoorna , Thatipelli Ravi Chander 
Published: May 2023

Hypertension elevates the risk of heart disease and stroke which are one of the most frequent causes of death. Fortunately, hypertension is manageable with the use of anti-hypertensives and a healthy lifestyle. However, patient non-adherence to the prescribed dosing regimen is the primary reason for uncontrolled blood pressure levels. Daily multiple doses of medication are one of the major reasons for patient non-compliance to the dosing regimen. Multiple doses of medication are a result of low solubility and high first-pass metabolism of anti-hypertensives. There are several approaches to improve the bioavailability of anti-hypertensives like polymeric and non-polymeric approaches to enhance solubility, avoiding first-pass metabolism through alternate routes of drug delivery and others. The objective of this review is to discuss different approaches to enhance the oral bioavailability of anti-hypertensive drugs.
Keywords: Solubility enhancements, solid lipid nanoparticles, hot melt extrusion, drug delivery, pharmacokinetics, poorly soluble, oral bioavailability.
Application of Lipids in Hot Melt Extrusion Technology
Authors: Dindigala Anil Kumar , Kodam Mounika Rajya Lakshmi 
Published: May 2023

Lipids are commonly used excipients in drug delivery for improving solubility of low soluble drugs, enhancing bioavailability through avoiding first pass metabolism through nanoparticulate approach, modifying the drug release, binders, permeation enhancers, transfection agents etc. Lipids alone or in combination of polymers are increasingly being used in hot melt extrusion (HME) technology for preparation of controlled release formulations, solid dispersions, self-emulsifying drug delivery systems, semi-solid formulations, solid lipid nanoparticles and others. Properties like low melting temperature, viscosity, ability to extrude at low temperature and ability to load high doses of drug favor use of lipids in HME technology. This review emphasizes the use of lipids for variety of applications in HME technology.
Keywords: Lipids, Hot melt extrusion, solubility, bioavailability, parameters.
Antidiabetic activity of methanol extract and fractions of Costus speciosus leaves in normal and alloxan induced diabetic rats
Authors: Siriwardhene Malitha Aravinda , Sabalingam Sriaandhal , Goonetilleke Anil 
Published: May 2023

Introduction: Costus speciosus is a common plant used for the treatment of diabetes mellitus and various other ailments in traditional medicine in Sri Lanka. The present study was conducted to investigate the hypoglycemic effect of the leaves of C. speciosus in both normal and alloxan induced male Wistar diabetic rat models. Methods: A methanolic extract of the leaves was produced and used for the preliminary phytochemicals screening. Methanol extract was further partitioned with different solvents (n-hexane, chloroform, ethyl acetate and n-butanol) according to their polarity. Male Wistar rats weighing 150-220 g were randomly divided during the test. In vivo antidiabetic activity of partitioned fractions of C. speciosus leaves was performed in normal rats and alloxan induced NIDDM rats. Standard t-test was used to determine statistical significance. Results: A glucose tolerance test with normal rats indicated that peak levels of blood glucose were reached in 90 minutes after the glucose load. It is noteworthy that the test group recorded a significantly (p < 0.05) lower blood glucose level at 90 minutes, indicating that the 80 % methanol extract exerted an overall hypoglycemic effect with normal rats at 90 minutes, despite being challenged with glucose load. The same dose showed an improvement in the glucose tolerance of alloxan-induced diabetic rats, reducing the blood glucose at 90 minutes by 60 % compared with control. These effects were found to be comparable with the effect of the synthetic drug glipizide at a dose of 20 mg/kg. In alloxan-induced diabetic rats, long term administration of the 80% methanolic extract of C. speciosus leaves daily for 6 weeks resulted in a significant lowering of fasting and postprandial serum glucose when compared to diabetic control rats. Conclusion: Diabetic rats group treated with C. speciosus extract displayed significantly (p<0.05) decreased blood glucose level compared to the control group.
Keywords: Alloxan, Costus speciosus, diabetes mellitus, hypoglycemia, anti-hyperglycemia
Effect of Gallic Acid on Distant Organ Stomach in Intestinal Ischemia Reperfusion Injury
Authors: Başaran Süreyya Özdemir , Kaplan Özge , Aşır Fırat 
Published: May 2023

Aim: To examine the effects of gallic acid (GA) in the stomach in rats undergoing intestinal ischemia/reperfusion (IR) with Beclin -1 immunostaining.
Material-Metod: 24 male Wistar albino rats were divided into control, IR and IR+GA groups. For the IR protocol, 60 minutes of ischemia and reperfusion were applied. The small intestines of the rats in the control group were removed by laparotomy and the abdomen was closed without applying anything else. Ischemia and reperfusion was applied to the superior mesenteric artery (SMA) for 60 minutes with a clamp in rats in the IR group. The blood flow was stopped with a clamp on the SMA of the rats in the IR+GA group and ischemia was applied for 60 minutes. 50 mg/kg gallic acid was given intraperitoneally to the animals, 60 minutes of reperfusion was performed, and the abdomen was closed. The stomach tissues were placed in paraffin blocks after routine histological follow-ups. Five micrometer-thick sections were taken from the paraffin blocks and stained with Hematoxylin-eosin and Beclin-1 immunostaining.
Results: In the IR group, degeneration of gastric folds, apoptosis of epithelial cells and degeneration of lamina muscularis were observed. In the IR + GA group, gastric folds improved, but cell infiltration in the lamina propria and degeneration in the muscular layer were observed. Beclin-1 expression was positively observed in the surface epithelial cells and gastric glands in the control group. In the IR group, it was observed that the gastric folds were positive on the surface cells and negative in the submucosa, while in the IR + GA group, it was intensely expressed in the gastric epithelium and gastric glands.
Conclusion: By increasing the expression of beclin-1, GA treatment induced autophagy in gastric mucosal cells, triggered the destruction of damaged cells and provided restoration of the mucosal layer.
Keywords: Beclin-1, gallic acid, apoptosis
An outline of endocrine disrupting chemicals and the influencing hormones: what the human society ought to know?
Authors: UTHAYANAN KAMALAKUMAR , Sundareswaran Seshadhri 
Published: May 2023

Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormones action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Significant advances in research into endocrine-disrupting chemicals (EDCs) and their health effects have elevated concerns in recent years about these chemicals among a number of international scientific and health organizations. The research reviewed here provides knowledge about EDC’s that health scientists can use to inform their research and decision-making processes.
Keywords: Endocrine disrupting chemicals, hormones action, cancer, reproductive impairment, cognitive deficits and obesity
Implantable Drug Delivery System: An Innovative Approach
Authors: Amreen Soha , Shahidulla S M , Sultana Aasia , Fatima Nimrah 
Published: May 2023

The conventional routes of drug administration has limited control over drug release and maintaining constant plasma therapeutic drug concentrations for longer periods of time. To avoid these problems associated with utilization of traditional dosage forms, there was essential need for development of new dosage forms which would discharge drugs at controlled rate for local activity. This led to improvement of Novel Drug Delivery Systems (NDDS) that offers optimisation of therapeutic properties of drugs and makes them safer, productive and dependable over traditional ways of administration. Implantable drug delivery system (IDDS) forms a part of novel drug delivery system. This route of administering medications allows targeted distribution, location specificity, constant release rate, low amount of drug requirements, and minimisation of adverse effects with improved efficacy. It provides possibility of administering drugs once weekly to yearly which otherwise previously require frequent daily dosing. Different implantable technologies are currently in use for many therapeutic applications such as in dentistry, ophthalmology, contraception and oncology. However, the expensiveness of this newly improved drug delivery system is quite high which hinders its large scale use. Moreover, the recently developed devices require further enhancement and hence thorough scientific trials are needed before wide implementation in populations.
Keywords: Implantable drug delivery, implants, drug delivery system, implantable pump, modulated drug delivery, novel drug delivery system
Formulation and evaluation of Transdermal Patch for the treatment of Migraine
Authors: Jajoo Vidhi Sunil , Shrirame Dnyaneshwar S. , Sawale Amol V. , Atram Sandeep C. 
Published: May 2023

A migraine is a specific kind of headache disorder that primarily affects the head. It can range in severity from mild to severe and is often accompanied by other symptoms like vomiting, nausea, illness, dizziness that gets worse with movement, photophobia, sonophobia, severe disability, or other types of nature. Triptans that are administered intravenously can be used to treat migraines and irritated injection sites. Transdermal delivery means that the medications will be administered through the skin in a precise, regulated manner. Our study aims to identify all possible transdermal patch combination and application for the treatment of migraines. The drug rizatriptan belongs to a group of drugs known as selective serotonin receptor agonists. It functions by constricting blood vessels in the brain, preventing the transmission of pain signals to the brain, and preventing the production of several naturally occurring compounds that produce pain, nausea, and other migraine symptoms. Verapamil belongs to the group of drugs known as calcium-channel blockers. It works by relaxing the blood vessels in order to reduce the workload of the heart. The Lambda max Rizatriptan and Verapamil is 278.9nm and 228nm respectively. They are soluble in most of the solvents. When used with verapamil, rizatriptan's transdermal patch improves patient compliance in those with hypertension. P2 patch shows the optimized results.
Keywords: Migraine, Rizatriptan, Verapamil, Bioavailability, Transdermal patch.
Peripheral Venous Catheter-Associated Bloodstream Infections (PVC-BSI) Risk Compared With Central Line-Associated Bloodstream Infections (CLABSI)
Authors: Feldheim Aryeh , Alicdan Jessica , Fong Calvin , Edward Myers Frank , Torriani Francesca J. 
Published: May 2023

Highlights
The rates of PVC-BSI and CLABSI were comparable outside of the ICU setting. The risk of Staphylococcus aureus bacteremia was greater in PVC-BSI. An EMR-based PVC-BSI active surveillance program is achievable in most hospitals.