bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Comparison of PC-Trees and PQ-Trees
Authors: Fink Simon D. , Pfretzschner Matthias , Rutter Ignaz 
Published: July 2023

PQ-trees and PC-trees are data structures that represent sets of linear and circular orders, respectively, subject to constraints that specific subsets of elements have to be consecutive. While equivalent to each other, PC-trees are conceptually much simpler than PQ-trees; updating a PC-tree so that a set of elements becomes consecutive requires only a single operation, whereas PQ-trees use an update procedure that is described in terms of nine transformation templates that have to be recursively matched and applied.

Despite these theoretical advantages, to date no practical PC-tree implementation is available. This might be due to the original description by Hsu and McConnell [
14
] in some places only sketching the details of the implementation. In this paper, we describe two alternative implementations of PC-trees. For the first one, we follow the approach by Hsu and McConnell, filling in the necessary details and also proposing improvements on the original algorithm. For the second one, we use a different technique for efficiently representing the tree using a Union-Find data structure. In an extensive experimental evaluation we compare our implementations to a variety of other implementations of PQ-trees that are available on the web as part of academic and other software libraries. Our results show that both PC-tree implementations beat their closest fully correct competitor, the PQ-tree implementation from the OGDF library [
6
,
15
], by a factor of 2 to 4, showing that PC-trees are not only conceptually simpler but also fast in practice. Moreover, we find the Union-Find-based implementation, while having a slightly worse asymptotic runtime, to be twice as fast as the one based on the description by Hsu and McConnell.
Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy–Induced Necrosis
Authors: Ghosh Santanu , Yang Rachel , Duraki Darjan , Zhu Junyao , Kim Ji Eun , Jabeen Musarrat , Mao Chengjian , Dai Xinyi , Livezey Mara R. , Boudreau Matthew W. , Park Ben H. , Nelson Erik R. , Hergenrother Paul J. , Shapiro David J. 
Published: July 2023

Abstract

Several emerging therapies kill cancer cells primarily by inducing necrosis. As necrosis activates immune cells, potentially, uncovering the molecular drivers of anticancer therapy–induced necrosis could reveal approaches for enhancing immunotherapy efficacy. To identify necrosis-associated genes, we performed a genome-wide CRISPR-Cas9 screen with negative selection against necrosis-inducing preclinical agents BHPI and conducted follow-on experiments with ErSO. The screen identified transient receptor potential melastatin member 4 (TRPM4), a calcium-activated, ATP-inhibited, sodium-selective plasma membrane channel. Cancer cells selected for resistance to BHPI and ErSO exhibited robust TRPM4 downregulation, and TRPM4 reexpression restored sensitivity to ErSO. Notably, TRPM4 knockout (TKO) abolished ErSO-induced regression of breast tumors in mice. Supporting a broad role for TRPM4 in necrosis, knockout of TRPM4 reversed cell death induced by four additional diverse necrosis-inducing cancer therapies. ErSO induced anticipatory unfolded protein response (a-UPR) hyperactivation, long-term necrotic cell death, and release of damage-associated molecular patterns that activated macrophages and increased monocyte migration, all of which was abolished by TKO. Furthermore, loss of TRPM4 suppressed the ErSO-induced increase in cell volume and depletion of ATP. These data suggest that ErSO triggers initial activation of the a-UPR but that it is TRPM4-mediated sodium influx and cell swelling, resulting in osmotic stress, which sustains and propagates lethal a-UPR hyperactivation. Thus, TRPM4 plays a pivotal role in sustaining lethal a-UPR hyperactivation that mediates the anticancer activity of diverse necrosis-inducing therapies.

Significance:
A genome-wide CRISPR screen reveals a pivotal role for TRPM4 in cell death and immune activation following treatment with diverse necrosis-inducing anticancer therapies, which could facilitate development of necrosis-based cancer immunotherapies.
The Cooperative Human Tissue Network of the National Cancer Institute: Supporting Cancer Research for 35 Years
Authors: McCall Shannon J. , Lubensky Irina A. , Moskaluk Christopher A. , Parwani Anil , Radin Kiley , Ramirez Nilsa C. , Von Menchhofen Zachery , Washington Mary K. , LiVolsi Virginia A. 
Published: July 2023

Abstract
The Cooperative Human Tissue Network was created by the NCI in 1987 to support a coordinated national effort to collect and distribute high quality, pathologist-validated human tissues for cancer research. Since then, the network has expanded to provide different types of tissue samples, blood and body fluid samples, immunohistologic and molecular sample preparations, tissue microarrays, and clinical datasets inclusive of biomarkers and molecular testing. From inception through the end of 2021, the network has distributed 1,375,041 biospecimens. It served 889 active investigators in 2021. The network has also taken steps to begin to optimize the representation of diverse communities among the distributed biospecimens. In this article, the authors review the 35-year history of this network, describe changes to the program over the last 15 years, and provide operational and scientific highlights from each of the divisions. Readers will learn how to engage with the network and about the continued evolution of the program for the future.
Data from A Novel Autologous CAR-T Therapy, YTB323, with Preserved T-cell Stemness Shows Enhanced CAR T-cell Efficacy in Preclinical and Early Clinical Development
Authors: Dickinson Michael J. , Barba Pere , Jäger Ulrich , Shah Nirav N. , Blaise Didier , Briones Javier , Shune Leyla , Boissel Nicolas , Bondanza Attilio , Mariconti Luisa , Marchal Anne-Laure , Quinn David S. , Yang Jennifer , Price Andrew , Sohoni Akash , Treanor Louise M. , Orlando Elena J. , Mataraza Jennifer , Davis Jaclyn , Lu Darlene , Zhu Xu , Engels Boris , Moutouh-de Parseval Laure , Brogdon Jennifer L. , Moschetta Michele , Flinn Ian W. 
Published: July 2023

<div>Abstract<p>CAR T-cell product quality and stemness (T<sub>stem</sub>) are major determinants of <i>in vivo</i> expansion, efficacy, and clinical response. Prolonged <i>ex vivo</i> culturing is known to deplete T<sub>stem</sub>, affecting clinical outcome. YTB323, a novel autologous CD19-directed CAR T-cell therapy expressing the same validated CAR as tisagenlecleucel, is manufactured using a next-generation platform in <2 days. Here, we report the preclinical development and preliminary clinical data of YTB323 in adults with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL; NCT03960840). In preclinical mouse models, YTB323 exhibited enhanced <i>in vivo</i> expansion and antitumor activity at lower doses than traditionally manufactured CAR T cells. Clinically, at doses 25-fold lower than tisagenlecleucel, YTB323 showed (i) promising overall safety [cytokine release syndrome (any grade, 35%; grade ≥3, 6%), neurotoxicity (any grade, 25%; grade ≥3, 6%)]; (ii) overall response rates of 75% and 80% for DL1 and DL2, respectively; (iii) comparable CAR T-cell expansion; and (iv) preservation of T-cell phenotype. Current data support the continued development of YTB323 for r/r DLBCL.</p>Significance:<p>Traditional CAR T-cell manufacturing requires extended <i>ex vivo</i> cell culture, reducing naive and stem cell memory T-cell populations and diminishing antitumor activity. YTB323, which expresses the same validated CAR as tisagenlecleucel, can be manufactured in <2 days while retaining T-cell stemness and enhancing clinical activity at a 25-fold lower dose.</p></div>
Single‐ Versus Dual‐Chamber Implantable Cardioverter‐Defibrillator for Primary Prevention of Sudden Cardiac Death in the United States
Authors: Margolis Gilad , Hamuda Nashed , Kobo Ofer , Elbaz Greener Gabby , Amir Offer , Homoud Munther , Madias Christopher , Heist Edwin Kevin , Ruskin Jeremy N. , Kazatsker Mark , Roguin Ariel , Leshem Eran , Rozen Guy 
Published: July 2023

Background
Routine addition of an atrial lead during an implantable cardioverter‐defibrillator (ICD) implantation for primary prevention of sudden cardiac death, in patients without pacing indications, was not shown beneficial in contemporary studies. We aimed to investigate the use and safety of single‐ versus dual‐chamber ICD implantations in these patients.

Methods and Results

Using the National Inpatient Sample database, we identified patients with no pacing indications who underwent primary‐prevention ICD implantation in the United States between 2015 and 2019. Sociodemographic and clinical characteristics, as well as in‐hospital complications, were analyzed. Multivariable logistic regression was used to identify predictors of in‐hospital complications. An estimated total of 15 940 patients, underwent ICD implantation for primary prevention of sudden cardiac death during the study period, 8860 (55.6%) received a dual‐chamber ICD. The mean age was 64 years, and 66% were men. In‐hospital complication rates in the dual‐chamber ICD and single‐chamber ICD group were 12.8% and 10.7%, respectively (
P
<0.001), driven by increased rates of pneumothorax/hemothorax (4.6% versus 3.4%;
P
<0.001) and lead dislodgement (3.6% versus 2.3%;
P
<0.001) in the dual‐chamber ICD group. Multivariable analyses confirmed atrial lead addition as an independent predictor for “any complications” (odds ratio [OR], 1.1 [95% CI, 1.0–1.2]), for pneumo/hemothorax (odds ratio, 1.1 [95% CI, 1.0–1.4]), and for lead dislodgement (odds ratio, 1.3 [95% CI, 1.1–1.6]).

Conclusions
Despite lack of evidence for clinical benefit, dual‐chamber ICDs are implanted for primary prevention of sudden cardiac death in a majority of patients who do not have pacing indication. This practice is associated with increased risk of periprocedural complications. Avoidance of routine implantation of atrial leads will likely improve safety outcomes.
Bidirectional Association Between Frailty and Cardiac Structure and Function: The Atherosclerosis Risk in Communities Study
Authors: Ramonfaur Diego , Skali Hicham , Claggett Brian , Windham B. Gwen , Palta Priya , Kitzman Dalane , Ndumele Chiadi , Konety Suma , Shah Amil M. 
Published: July 2023

Background
Frailty and heart failure frequently coexist in late life. Limited data exist regarding the longitudinal associations of frailty and subclinical cardiac dysfunction. We aim to quantify the association of frailty with longitudinal changes in cardiac function and of cardiac function with progression in frailty status in older adults.

Methods and Results
Participants in the Atherosclerosis Risk in Communities cohort underwent frailty assessments at Visit 5 (V5; 2011–2013), V6 (2016–2017), and V7 (2018–2019), and echocardiographic assessments at V5 and V7. We assessed the association between frailty status at V5 and changes in frailty status from V5 to V7 and changes in cardiac function over 6 years. We then evaluated the association of cardiac function measured at Visit 5 with progression in frailty status over 4 years. Multivariable regression models adjusted for demographics and comorbidities. Among 2574 participants free of heart failure at V5 and V7 (age 74±4 years at V5 and 81±4 years at V7), 3% (n=83) were frail. Frailty at V5 was associated with greater left atrial volume index and E/e' ratio at V5 and 7. Participants who transitioned from robust at V5 to frail at V7 demonstrated greater increases in left ventricular mass index, left atrial volume index, and E/e' over the same period. Among 1648 robust participants at Visit 5, greater left ventricular mass index and mean wall thickness, lower tissue Doppler imaging e', and higher E/e' ratio at Visit 5 were associated with progression in frailty status.

Conclusions
Among robust, older adults free of heart failure, progression in frailty and subclinical left ventricular remodeling and diastolic dysfunction are interrelated.
Learning Intention-Aware Policies in Deep Reinforcement Learning
Authors: Zhao Tingting , Wu Shuai , Li Guixi , Chen Yarui , Niu Gang , Sugiyama Masashi 
Published: July 2023

AbstractDeep reinforcement learning (DRL) provides an agent with an optimal policy so as to maximize the cumulative rewards. The policy defined in DRL mainly depends on the state, historical memory, and policy model parameters. However, we humans usually take actions according to our own intentions, such as moving fast or slow, besides the elements included in the traditional policy models. In order to make the action-choosing mechanism more similar to humans and make the agent to select actions that incorporate intentions, we propose an intention-aware policy learning method in this letter To formalize this process, we first define an intention-aware policy by incorporating the intention information into the policy model, which is learned by maximizing the cumulative rewards with the mutual information (MI) between the intention and the action. Then we derive an approximation of the MI objective that can be optimized efficiently. Finally, we demonstrate the effectiveness of the intention-aware policy in the classical MuJoCo control task and the multigoal continuous chain walking task.
Ranges of Randomization
Authors: Agranov Marina , Ortoleva Pietro 
Published: July 2023

Abstract
A growing literature has shown that people sometimes prefer to randomize between two options. We investigate how prevalent this behavior is in an experiment using a novel and simple method. Subjects face a list of questions in which one of the alternatives is fixed and the other varies, like a Multiple Price List, but in each row they can randomize between the options. We find that the majority of subjects chose to randomize in the majority of questions, and notably, they did so for ranges of values that were “very large.”
Does Economics Make You Sexist?
Authors: Paredes Valentina , Paserman M. Daniele , Pino Francisco J. 
Published: July 2023

Abstract
We provide direct evidence on explicit and implicit biases against women among students in economics relative to other fields. We conducted a large scale survey among undergraduates in Chile, among both entering first-year students and students in years 2 and above, combining a wide battery of measures to create an index of gender bias. Economics students are more biased than students in other fields. There is some evidence that economics students are more biased already upon entry, before exposure to economics classes. The gap becomes more pronounced among students in years 2 and above, especially for male students.
Did the Federal Reserve Break the Phillips Curve? Theory & Evidence of Anchoring Inflation Expectations
Authors: Bundick Brent , Smith A. Lee 
Published: July 2023

Abstract
In a macroeconomic model with drifting long-run inflation expectations, the anchoring of inflation expectations manifests in two testable predictions. First, expectations about inflation far in the future should no longer respond to news about current inflation. Second, better anchored inflation expectations weaken the relationship between unemployment and inflation, flattening the reduced-form Phillips curve. We evaluate both predictions and find that the Federal Reserve's communication of a numerical inflation objective, first through its Summary of Economic Projections and later through the announcement of a 2 percent target in 2012, better anchored inflation expectations. Moreover, inflation expectations in the United States have remained anchored amid the volatility of the COVID-19 pandemic. In contrast, similar analysis reveals no evidence of anchoring in Japan despite the adoption of a numerical inflation target.
High-Pressure, High-Paying Jobs?
Authors: Nagler Markus , Rincke Johannes , Winkler Erwin 
Published: July 2023

Abstract
Work-related stress has reportedly increased over time. Using worker-level survey and experimental data, we investigate the labor market consequences of work pressure. We build a measure of pressure strongly associated with adverse health outcomes and show that pressure comes with a sizable earnings premium, reflecting workers' willingness-to-pay to avoid pressure. As expected, we do not find a premium among civil servants who face strong labor market frictions. Our experimental evidence is consistent with workers sorting into high-pressure jobs and with a sizable market-level compensating differential. Differences in the prevalence and valuation of work pressure explain substantial shares of wage inequality.
Multiscale Influences on Rainfall in Northeast Australia
Authors: Dao Thi Lan , Vincent Claire L. , Lane Todd P. 
Published: July 2023

Abstract
This study examines the multiscale modulation of mean and extreme rainfall in Northeast (NE) Australia under different background modes of variability, which is a new aspect given the high-resolution and long-term observational datasets. Daily rainfall probability is significantly modified by the Madden–Julian oscillation (MJO), and its influence varies with the seasons and is associated with atmospheric circulation anomalies. Rainfall generally decreases during El Niño and increases during La Niña years; however, there is a notable spatial nuance to El Niño–Southern Oscillation (ENSO)-associated extreme rainfall, with some locations showing the opposite precipitation response to the typical ENSO–rainfall relationship. Despite more precipitation overall in La Niña years, the mean and extreme precipitation responses to the MJO appear to be stronger and more often statistically significant during El Niño compared to La Niña periods. The impact of ENSO on the MJO–rainfall relationship is stronger than the variation of the MJO itself with ENSO, and likely reflects a change in the MJO modulation of rain-bearing atmospheric processes. During El Niño periods, diurnal rainfall amplitude is generally stronger in the central and southern subtropical parts of the study area than during La Niña periods, while the opposite tendency occurs in the northern tropical part. The diurnal cycle of both mean and extreme precipitation is amplified during suppressed convection phases compared to enhanced convection phases of the MJO. In general, the peak time of diurnal cycle does not change with MJO regimes, but there are some notable differences in rainfall propagation between enhanced and suppressed MJO phases.

Significance Statement
This study presents a new perspective on the relationship between precipitation in Northeast (NE) Australia and two important climate modes, the Madden–Julian oscillation (MJO) and El Niño–Southern Oscillation (ENSO). Rainfall in NE Australia is strongly influenced by the MJO, ENSO, and their interaction, suggesting that climate models need to capture both individual climate modes and their interactions for reliable rainfall projections. These findings have societal climate risk implications, as NE Australia is an area prone to catastrophic flooding due to extreme rainfall.
DPCA-Based Doppler Radar Measurements from Space: Effect of System Errors on Velocity Estimation Performance
Authors: Durden S. L. , Beauchamp R. M. , Graniello S. , Venkatesh V. , Tanelli S. 
Published: July 2023

Abstract
The displaced phased center antenna (DPCA) method of clutter cancellation for ground moving target detection from airborne platforms has been in use for a number of decades. Application of the DPCA method for spaceborne Doppler weather radar velocity estimation was suggested in 2007. The initial description and analysis of the technique was followed several years ago by demonstration using a multiantenna airborne radar. Recent reviews of methods and technology for spaceborne cloud and precipitation radar have also mentioned possible use of DPCA. However, to date, analyses of the application of DPCA to spaceborne Doppler weather radar have assumed that the two channels and antennas are identical, including perfect alignment, and that the DPCA condition is well-satisfied. This study uses simulation to examine the effects of relaxing these assumptions. The simulation method and its validation are discussed, with companion analytical calculations in the appendix. Next, simulations are used to show the effects on the Doppler estimates from errors in pointing and positioning relative to the ideal DPCA. The DPCA technique is relatively robust to possible errors, indicating that a practical DPCA radar system can provide precise Doppler measurements from space.

Significance Statement
Analytical and simulation results show that the displaced phase center antenna approach can enable spaceborne atmospheric Doppler radar measurements with good accuracy, even in the presence of antenna mispointing and other system errors.
Balance, self-efficacy and collective individualism: Young people’s ideal eater types
Authors: Bohm Ingela , Bengs Carita 
Published: July 2023

Background: In health education, there is a risk of giving overly prescriptive recommendations, potentially activating conflicting in-group norms that reduce message receptiveness. For example, the notion of ‘unhealthy youth’ is a stereotype which suggests that young people are expected to make unhealthy choices. If such in-group norms are activated as part of health education, the will to emulate healthy out-group behaviour may decrease. Objective: The objective of this study was to explore how young people construct different types of eaters in relation to health recommendations. Method: Group interviews were conducted with 31 students aged 10–16 years (from school grades 5 and 8) in northern Sweden and data were analysed using reflexive thematic analysis. Results: The analysis yielded eight ideal eater types: healthy-but-not-too-healthy; obsessively healthy; devil-may-care; destabilised; contextual; powerless; intuitive; and discontented eaters. Participants’ preferred types did not overly regulate their eating, bute intuitively ate what they liked and/or needed in a balanced way. They were also receptive to social and contextual cues without being completely guided by them. Conclusion: Even in the current era of individualism, food retains its social meanings, and young people’s views of healthy eating are shaped by valued social groups. We therefore recommend the promotion of shared individualism as part of health education, where the expression of individual taste is encouraged alongside adherence to group norms. It is also crucial to highlight how healthy and unhealthy foods can coexist as part of a balanced diet.
Mechanical and thermal properties of polyvinyl acetate foams reinforced with biopolymers
Authors: Ergun Mehmet Emin , Ozen Ertan , Yildirim Nadir , Dalkilic Berk , Baysal Ergun 
Published: July 2023

The study developed and designed polyvinyl acetate (PVAc) foams using advanced freeze-drying technology, which exhibited good heat-insulating ability, flame retardancy, and mechanical properties. Different combinations of bleach kraft pulp, water-soluble chitosan, and zinc borate were used to reinforce the foams. The foams exhibited desirable compression and flexural properties, with compression strength and compression modulus ranging from 0.01 MPa to 0.08 MPa and 0.05 MPa to 0.29 MPa, respectively, while flexural strength and flexural modulus ranged from 0.12 MPa to 5.37 MPa and 9.86 MPa to 260,85 MPa, respectively. The use of zinc borate as a reinforcement resulted in improved thermal properties and reduced mass loss at 600°C by 20.69%. Thermal conductivity tests indicated that the foams had low thermal conductivity values ranging from 0.037 W/mK to 0.074 W/mK. The foams with zinc borate (60 g/L) and high molecular weight water-soluble chitosan (70 g/L) reinforcement exhibited high limiting oxygen index (LOI) of 28.72%. Overall, the results suggest that the PVAc foams could serve as a promising sustainable alternative in thermal insulation and construction fields.