bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEKTIVITAS DARI EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia) SEBAGAI KANDIDAT ANTIDIABETES PADA TIKUS PUTIH (Rattus norvegicus) GALUR WISTAR
Authors: Rollando Rollando , Afthoni Muhammad Hilmi , Cesa Fibe Yulinda , Monica Eva , Wibawanty Nurul Azmi 
Published: June 2023

Latar belakang: Penyakit diabetes di Indonesia menduduki peringkat ketiga penyakit kronis terbanyak dengan prevalensi 5,6%. Terapi penyakit diabetes memerlukan waktu yang panjang dan memiliki resiko efek samping yang tinggi. Tanaman bihanong secara empiris digunakan untuk menurunkan kadar gula darah. Daun binahong memiliki metabolit sekunder seperti flavonoid, saponin, dan tanin yang secara ilmiah dapat menurunkan kadar gula darah. Tujuan: Penelitian ini menganalisis pengaruh induksi ekstrak etanol daun binahong terhadap penurunan gula darah tikus putih galur Wistar. Metode: Desain penelitian adalah post test control group desaign yang menggunakan 25 ekor tikus dan dibagi menjadi 5 kelompok. Dilakukan induksi streptozotocin (STZ) secara intraperitoneal dengan dosis 150 mg/KgBB untuk meningkatkan kadar glukosa pada hewan uji. Kontrol negatif diberikan 0,5% Na-CMC, kontrol positif diberikan glibenklamid, kelompok perlakuan I diberi ekstrak dengan dosis 80 mg/KgBB, kelompok perlakuan II dengan dosis 100 mg/KgBB, dan kelompok perlakuan III dengan dosis 120 mg/KgBB. Pengukuran kadar glukosa darah dilakukan setelah penginduksian STZ dan pemeriksaan dilakukan setiap harinya. Kadar glukosa dalam darah dianalisis menggunakan uji statistik one way ANOVA dan dilanjutkan dengan uji Post Hoc LSD. Hasil: Hasil menunjukkan bahwa setiap kelompok memiliki perbedaan yang signifikan pada efek terapi (p ≤ 0,05). Simpulan: Konsentrasi yang direkomendasikan untuk memberikan efek penurunan kadar gula darah yaitu pada dosis 80 mg/KgBB.
KORELASI NEUTROPHIL LYMPHOCYTE RATIO (NLR), SERUM GLUTAMIC OXALOACETIC TRANSAMINASE (SGOT) DAN SERUM GLUTAMIC PYRUVIC TRANSAMINASE (SGPT) PADA PASIEN COVID-19 SEBAGAI INDIKATOR INFLAMASI ORGAN HATI
Authors: Hasanah Fathul Hidayatul , Wahyuni Sri , Sari Fita 
Published: June 2023

Latar belakang: Aktivitas enzim hati Serum Glutamic Oxaloacetic Transaminase (SGOT) dan Serum Glutamic Pyruvic Transaminase (SGPT) akan meningkat ketika terjadi infeksi. Tujuan: untuk mengetahui korelasi NLR terhadap SGOT dan SGPT pada Pasien Covid-19 Sebagai Indikator Inflamasi Organ Hati. Metode: Desain penelitian menggunakan Study cross sectional dan tehnik sampling accidental. Responden berjumlah 38 pasien Covid-19 di rumah sakit Umum Daerah Nganjuk dengan kriteria inklusi pasien Covid-19 tidak memiliki riwayat penyakit liver dan kriteria ekslusi adalah pasien covid 19 dengan penyakit infeksi lain (Tuberculosis, Tipoid, demam dengue) dan penyakit autoimun. Hasil: Diperoleh nilai rata-rata NLR 7,0 >3,13 dengan 74% meningkat,Kadar rata-rata SGPT 58,5 UI dan 61% mengalami peningkatan, sedang rata-rata SGPT 46,7 UI dan 76% berada di rentang normal. Berdasarkan uji perason nilai NLR terhadap SGOT ( sig = 0,629 > 0,05 dan r = 0,081) dan NLR terhadap SGPT (sig = 0,575 >0,05 dan r= 0,094). Simpulan: tidak ada korelasi antara NLR terhadap SGOT dan SGPT pada pasien Covid-19
TINJAUAN PROSEDUR KELENGKAPAN PENCATATAN DATA DEMOGRAFI PASIEN BARU DI RSUD X TRENGGALEK
Authors: Susilowati Indah , Nurkhalim Ratna Frenty , Hasanah Latifah 
Published: June 2023

Latar belakang: Bentuk dokumentasi pertama kali dalam rekam medis dimulai dengan pencatatan data demografi pasien baru yang pertama kali datang ke rumah sakit. Isian data demografi mencakup identitas diri yang lengkap serta merupakan penentu upaya pemberian layanan kesehatan. Saat survei ditemukan kekosongan data identitas pasien yang dapat mempengaruhi isi dan kualitas rekam medis, secara keseluruhan bisa mengaburkan identifikasi pasien yang sesuai identitasnya. Tujuan :Penelitian ini adalah untuk meninjau prosedur mengenai kelengkapan pencatatan data demografi pasien rawat jalan baru di RSUD X Trenggalek. Metode :Penelitian ini termasuk deskriptif kuantitatif, dengan 96 sampel yang diambil secara accidental sampling, variabel penelitiannya kebijakan, standar operasional prosedur dan formulir pendaftaran pasien baru rawat jalan Hasil: Terdapat kebijakan dan standar operasional prosedur yang mengatur tentang pencatatan data demografi pasien, namun pelaksanannya masih ditemukan ketidaklengkapan formulir pendaftaran pasien baru rawat jalan sebesar 31,25%, yang sudah lengkap pengisiannya adalah 68,75%. Saran: perbaikan melakukan sosialisasi untuk pemahaman prosedur yang sudah ditentukan, evaluasi berkala pencatatan dan melengkapi formulir pendaftaran pasien baru rawat jalan
Generationenkonflikt in der Kanzlei – Eine Mediation im Stil der Klärungshilfe
Authors: Metzger Tilman 
Published: June 2023

Einer Kanzlei mit 10 Rechtsanwälten drohte die Abspaltung der jüngeren Mitglieder. In einer zweitägigen Mediation konnten die Frustrationen geklärt und Grundlagen für die Fortsetzung der Zusammenarbeit gelegt werden. Der Mediator arbeitete nach dem Ansatz der Klärungshilfe, entwickelt von dem Di­plompsychologen Dr. Christoph Thomann. Folgende für die Klärungshilfe typische Methoden kamen u. a. zur Anwendung: Mini-Kontrakte, Konfliktskizzen, Differenzierung zwischen vier Themenarten, Doppeln, Dialogisieren, Vertiefen sowie Zwischenerklärungen. Die wesentliche Voraussetzung für die Beilegung des Konfliktes im Wege der Klärungshilfe war, dass alle Beteiligten gemeinsam sich drei Viertel des Mediationsworkshops intensiv mit ihrer schwierigen Vergangenheit und Gegenwart auseinandersetzten. Die so transformierten Beziehungen und die erarbeiteten Informationen schufen die Basis für realistische Vereinbarungen.
Bisnis Nener dalam Perspektif Hukum Ekonomi Syariah (Studi Kasus CV. Simpatik Buleleng Bali)
Authors: Handayani Eka 
Published: June 2023

milkfish business to find out local and export business at the CV. Simpatik Buleleng pond company, this research methods, types of research used is field research, collected data by researchers include primary and secondary data, while the source obtained by observation, interview, and documentation, then teh data is analyzed descriptively throuh, display, reduction, verification and prescriptive, so that it produces the result that is 1. Companies set prices unilaterally, islam provides freedom in specify prices by Wahbah Zuhaili, Ibnu Araby, Imam Malik, dan Ibnu Taimiyah. 2. Nener sample calculation, becomes an agreement between siler and buyer. 3. The Fuqoha’ allow shigat fi’liyah (actions) clarity of sale and purchase transaction contracts, as well as exchanging goods using money this is allowed by Ibnu Qosim in the kitab athul qorib. 4. The high price of nener is allowed to use a Musawama sale and purchase contract (bargaining) 5. Ordering nener in larvae tuber not yet old enough to be harvested is a prohibition on buying and selling (gharar) by Imam Nawawi and Imam Al-Qorafi while according to Syafi’iyyah, Abu Yusuf Muhammad (Hanafiyah) and one narration of madhab Ahmad states that it is invalid, malikiyah and one narration of hanabilah that it is forbidden to buy and sell food that has not been received by hand. 6. Late payment of nener’s money, according to the argument of ijma’ by Ibnu Qoudamah rahimahullah stating that the sale and purchase is valid in accordance with the compensation given. 7.Nener’s death is the responsibility of the seller who should be the responsibility of the buyer, in this case it is contrary to the opinion of al-qadhi and scholars who belong to his group namely goods that have been determined to be the responsibility of the buyer. 8. Payment via ATM is allowed because the ijab & qobul consent can be fulfilled properly determined by the fiqh commission at the islamic conference organization number 107 on 17-23 sya’ban in 1410 H.
Cholangiocarcinoma: Pathologic and Molecular Classification in the Era of Precision Medicine
Authors: Gopal Purva , Robert Marie E. , Zhang Xuchen 
Published: June 2023

Context.—
Cholangiocarcinoma (CCA) is a heterogeneous cancer of the bile duct, and its diagnosis is often challenging.

Objective.—
To provide insights into state-of-the-art approaches for the diagnosis of CCA.

Data Sources.—
Literature review via PubMed search and authors’ experiences.

Conclusions.—
CCA can be categorized as intrahepatic or extrahepatic. Intrahepatic CCA is further classified into small-duct–type and large-duct–type, whereas extrahepatic CCA is classified into distal and perihilar according to site of origin within the extrahepatic biliary tree. Tumor growth patterns include mass forming, periductal infiltrating, and intraductal tumors. The clinical diagnosis of CCA is challenging and usually occurs at an advanced tumor stage. Pathologic diagnosis is made difficult by tumor inaccessibility and challenges in distinguishing CCA from metastatic adenocarcinoma to the liver. Immunohistochemical stains can assist in differentiating CCA from other malignancies, such as hepatocellular carcinoma, but no distinctive CCA-specific immunohistochemical profile has been identified. Recent advances in next-generation sequencing–based high-throughput assays have identified distinct genomic profiles of CCA subtypes, including genomic alterations that are susceptible to targeted therapies or immune checkpoint inhibitors. Detailed histopathologic and molecular evaluations of CCA by pathologists are critical for correct diagnosis, subclassification, therapeutic decision-making, and prognostication. The first step toward achieving these goals is to acquire a detailed understanding of the histologic and genetic subtypes of this heterogeneous tumor group. Here, we review state-of-the-art approaches that should be applied to establish a diagnosis of CCA, including clinical presentation, histopathology, staging, and the practical use of genetic testing methodologies.
ARENDT’S PERSPECTIVE ON THE ROLE OF THE INTELLECT IN THE ACT OF AVOIDING EVIL
Authors: Shelomita Selamat  
Published: June 2023

Human being is a rational animal who has the capability to think. The activity of thinking distinguishes man from other animals. Nevertheless, there are some people who do not use their capability to think. Many people just follow what other people said without really considering what they actually do. For Hannah Arendt, this is one of the factors that causes many evils have occurred in our daily life. Moreover, she used the term of the banality of evil to describe the evil that has happened because of the culprit’s inability to think. Therefore, she emphasized the importance of thinking in every human being. For her, thinking makes human to avoid grave evil.
MEMBOYONG KEPENTINGAN PRIBADI MENUJU KEUTAMAAN SOSIOLOGIS
Authors: Herwindo Chandra  
Published: June 2023

Self-interest starts at the early life of human beings. Along with his body self-interests also grows in the biological growth of a child. Mankind tends to do everything for his own interest, such as to fulfill his needs. Meanwhile, there is another terminology that close to self-interest, i.e. selfishness. Regardless we have to determine the meaning of both terminologies. Self-interest depends on condition, while selfishness focus on ones own interest. Selfishness has no value per se, and it is different with self-interest. In social relationship, self-interest is not without problem. In this paper, we try to describe several conditions of such relationship by using the theory of George Simmel. Is there any condition to bring the self-interest for a good relationship? Therefore, the purpose of this paper is to achieve the knowledge and an encouragement for the highest social virtue in relationship.
PERSPEKTIF YURIDIS-KANONIS TENTANG KEWAJIBAN IMAM MENJAGA RAHASIA PENGAKUAN
Authors: Rikardus Jehaut  
Published: June 2023

Artikel ini bertujuan untuk menegaskan kembali ajaran Gereja menyangkut kewajiban bapa pengakuan untuk menjaga rahasia pengakuan. Pertama-tama diuraikan secara singkat bagaimana hal ini berkembang dalam sejarah, khususnya kanon 21 dari Konsili Lateran IV (1215) dan Kodeks 1917. Pengetahuan tentang sejarah penting karena membantu kita memahami bagaimana tema ini berkembang dan menjadi dasar hukum Kodeks 1983. Kemudian dibahas tentang ketentuan normatif kan. 889, § 1 yang berbicara tentang rahasia pengakuan dan kewajiban bapa pengakuan menjaga rahasia tersebut. Rahasia pengakuan tidak dapat diganggu gugat karena merupakan unsur esensial dari sakramen tobat dan merupakan bagian dari hukum ilahi. Bapa pengakuan yang terbukti melanggar kewajiban ini akan dikenai sanksi ekskomunikasi otomatis atau hukuman lain yang diputuskan oleh otoritas gereja yang berwenang. Tantangan memang tidak ringan dewasa ini, khususnya di tempat di mana imam dipaksa untuk membuka rahasia pengakuan dalam kasus-kasus tertentu. Pemaksaan seperti ini harus dilawan karena merupakan pelanggaran terhadap kebebasan gereja dan kebebasan beragama. Perlawanan seperti ini merupakan sebuah keharusan, bila perlu sampai menumpahkan darah sekalipun.
Resoconto sul Convegno Nazionale SIRD 2023: «La SIRD tra passato, presente e futuro. Il ruolo della ricerca educativa ai tempi del COVID, della terza guerra mondiale, della globalizzazione e della crisi ecologica»
Authors: De Vincenzo Conny 
Published: June 2023

The National Conference «SIRD between past, present and future. The role of educational research in the times of COVID, world war III, globalization and the ecological crisis» was organized by the Italian Society of Educational Research (SIRD). The conference was organized on the occasion of SIRD’s 30th anniversary and aimed to foster active discussions on the key challenges that educational research has encountered in recent years. The event started with a plenary session that retraced the significant milestones that characterized the founding of SIRD, featuring speeches from past presidents of the society. Following, the conference delved into thematic working groups, which focused on relevant research topics including Teaching Learning Centers, PNRR and guidance, career access and progression, university teaching, research and teacher training, internationalization, 11/D2 coordination, doctoral training, quality of publications, and internationalization of journals. This paper provides a summary of the conference’s primary discussions, highlighting their relevance within the context of contemporary educational research.
A novel fast pedestrian recognition algorithm based on point cloud compression and boundary extraction
Authors: Zhang Yanjun 
Published: June 2023

Reason
Pedestrian recognition has great practical value and is a vital step toward applying path planning and intelligent obstacle avoidance in autonomous driving. In recent years, laser radar has played an essential role in pedestrian detection and recognition in unmanned driving. More accurate high spatial dimension and high-resolution data could be obtained by building a three-dimensional point cloud. However, the point cloud data collected by laser radar is often massive and contains a lot of redundancy, which is not conducive to transmission and storage. So, the processing speed grows slow when the original point cloud data is used for recognition. On the other hand, the compression processing of many laser radar point clouds could save computing power and speed up the recognition processing.

Methodology
The article utilizes the fusion point cloud data from laser radar to investigate the fast pedestrian recognition algorithm. The focus is to compress the collected point cloud data based on the boundary and feature value extraction and then use the point cloud pedestrian recognition algorithm based on image mapping to detect pedestrians. This article proposes a point cloud data compression method based on feature point extraction and reduced voxel grid.

Results
The Karlsruhe Institute of Technology and Toyota Technological Institute data set is used to investigate the proposed algorithm experimentally. The outcomes indicate that the peak signal-to-noise ratio of the compression algorithm is improved by 6.02%. The recognition accuracy is improved by 16.93%, 17.2%, and 16.12%, corresponding to simple, medium, and difficult scenes, respectively, when compared with the point cloud pedestrian recognition method based on image mapping, which uses the random sampling method to compress the point cloud data.

Conclusion
The proposed method could achieve data compression better and ensure that many feature points are retained in the compressed Point Cloud Data (PCD). Thus, the compressed PCD achieves pedestrian recognition through an image-based mapping recognition algorithm.
Socio- psychological Constructs and Perceived Economic Variables Impacting the Farmer Producer Organization members in Kerala: A Quantitative Analysis
Authors: Jose Asha Elizabeth , Jayalekshmi G. , Lade Ashish Homraj 
Published: June 2023

The present study focused on assessing the socio-psychological constructs and perceived economic variables affecting the functioning of the FPOs. An ex-post facto research design was used in the study. The study was conducted in Kerala. Districts from Northern, Central, and Southern Kerala having the maximum number of FPOs were selected for the study. Wayanad from Northern Kerala, Idukki from Central Kerala, and Trivandrum from Southern Kerala were purposively selected for the study. A purposive sampling technique was used for the selection of the FPOs. Two functioning FPOs were purposively selected from the three districts based on discussion with National Bank for Agriculture and Rural Development (NABARD), Small Farmers Agribusiness Consortium (SFAC), and Krishi Vigyan Kendra (KVK). From each selected FPO, 20 farmer members were randomly selected. A total of 40 farmers were surveyed from each district. Thus, from six FPOs in three districts, 120 farmer members were selected. A random sampling technique was used for the selection of the farmer members from each FPOs. The study rigorously examined parameters such as age, education, annual income, scientific orientation, training attended, credit orientation, social participation, group cohesiveness, and creativity levels among FPO members. It was observed that FPOs comprised middle-aged farmers who completed their education up to the high school level. A substantial proportion of FPO members fell within the medium income category, scientific orientation, and have attended relatively fewer training sessions. Additionally, the research unveiled the fact that the majority of the FPO members belonged to a medium level of credit orientation, social participation, group cohesiveness, and creativity among FPO members. These factors play a critical role in shaping the dynamics and effectiveness of FPOs.
Real World Evidence of Bempedoic Acid on Efficacy and Safety in Patients with Uncontrolled LDL-c and at High Risk of CVD
Authors: Manoj S. , Shah Jay , Kumar Dilip , Pradhan Akshaya , Kinare Amit B. , Sharma Ashwani Kumar , Aditya M. S. , Raj Ram Anil , Raina Akhter Amin , Patel Ashish , Das Biswajit , Bathe Dipak Suresh , Muchhala Sameer , Jhaveri Kunal 
Published: June 2023

Background and Objective: Cardiovascular disease (CVD) is a significant cause of morbidity and mortality worldwide, with high-risk patients requiring effective management to reduce their risk of cardiovascular events. Bempedoic acid is a novel therapeutic agent recently approved as an add-on therapy to statins in patients with uncontrolled LDL-c. Bempedoic acid inhibits cholesterol synthesis in the liver, which ultimately reduces the risk of cardiovascular events. Therefore, the present study aims to assess the efficacy and safety of bempedoic acid in patients with uncontrolled LDL-c (Previously on moderate or high-intensity statins) with a high risk of CVD in real-world settings.
Methods: This is a multicenter, retrospective, observational study on the data of high-risk-CVD patients collected from Bempedoic Acid on Efficacy and Safety in patients (BEST) Registry. The clinical data of 140 patients who were already on statin therapy and were receiving Bempedoic acid at a dose of 180 mg, along with measurements of the level of LDL-c, HbA1c, HDL, TG, TC, PPPG, FPG, AST, ALT, serum creatinine was taken into consideration. The primary outcome includes a change in LDL-c level, and secondary outcomes involve a change in the level of HbA1c, HDL, TG, TC, PPPG, FPG, AST, ALT, and serum creatinine at week 12 and 24. Adverse events were reported at both time points.
Results: A total of 140 patients were included in the present study with a mean age of 51.8 ± 9.2 years and had primary confirmed diagnosis of dyslipidemia with uncontrolled LDL-c. The mean levels of LDL-c decreased from the mean baseline value of 142.67 ± 46.49 mg/dL, to 106.78 ±33.92 mg/d; a statistically significant reduction by 23.23% (p < 0.01) at week 12. Similarly, at week 24, the mean LDL-c value reduced to 90.39 ± 38.89 mg/dL. A 33.38 % decrease was observed (p < 0.01). Other parameters such as non-HDL, FPG, PPPG, AST and serum creatinine also showed statistically significant reduction at week 12 and week 24.
Conclusion: The present study demonstrates that bempedoic acid is an effective add-on medication in lowering LDL-c levels in high-risk CVD patients with uncontrolled LDL-c.
Farmers Feedback on the Block Level Agro-met Advisory through District Agro Met Unit (DAMU) in Sirohi District of Rajasthan, India
Authors: Kumar Sushil , Singh Hari , Choudhary Ram Swaroop , Singh Mahendra 
Published: June 2023

The study was conducted during 2021‒22 in jurisdiction of Sirohi district, Rajasthan, India to analysis the importance of agromet advisories and how much it beneficial to farmers.
Indian meteorological department (IMD) and Indian Council of Agricultural Research under a centrally sponsored scheme of Ministry of Earth Science, Govt. of India established District Agro-Met Units (DAMUs) in Krishi Vigyan Kendra in 2019. DAMU will frame the block level agromet advisory services using multichannel communication mechanism in the country to reach out to 95.4 million farming households. On the basis of the weather forecasting,advisory messages prepared by Scientists of Krishi Vigyan Kendra Sirohi and sent to Famers of different blocks of Sirohi district viz., Sirohi, Sheoganj, Abu road, Pindwara & Reodar through various channel like,whats app & text messages on mobile, newspaper, meghdoot app etc. on every Tuesday & Friday. The study was undertaken in all blocks of Sirohi district of Rajasthan. Broadcasting of Agro-met Advisory Bulletin is continued as it plays an important role in planning the farm operations. There are many farmers in district who has been benefited with agro advisory service but for the easy analysis and observation, response of 200 farmers are kept in this study. Responses recorded on the basis of block, farming situation, medium of weather forecasting information, usefulness of weather forecasting, agricultural operations done by use of agro advisory, satisfaction by advisory services, accuracy of agro advisory service, losses observed due to aberrant weather conditions.