bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ursodeoxycholic acid in the management of symptomatic gallstone disease: systematic review and clinician survey
Authors: Hall Lewis , Halle-Smith James , Evans Richard , Toogood Giles , Wiggins Tom , Markar Sheraz R , Kapoulas Spyros , Super Paul , Tucker Olga , McKay Siobhan C 
Published: March 2023

Abstract

Background
Symptomatic gallstones are common. Ursodeoxycholic acid (UDCA) is a bile acid that dissolves gallstones. There is increasing interest in UDCA for symptomatic gallstones, particularly in those unfit for surgery.

Method
A UK clinician survey of use and opinions about UDCA in symptomatic gallstones was performed, assessing clinicians’ beliefs and perceptions of UDCA effectiveness. A systematic review was performed in accordance with the PRISMA guidelines. PubMed, MEDLINE, and Embase databases were searched for studies of UDCA for symptomatic gallstones (key terms included ‘ursodeoxycholic acid’; ‘UDCA’; ‘biliary pain’; and ‘biliary colic’). Information was assessed by two authors, including bias assessment, with independent review of conflicts.

Results
Overall, 102 clinicians completed the survey, and 42 per cent had previous experience of using UDCA. Survey responses demonstrated clinical equipoise surrounding the benefit of UDCA for the management of symptomatic gallstones, with no clear consensus for benefit or non-benefit; however, 95 per cent would start using UDCA if there was a randomized clinical trial (RCT) demonstrating a benefit. Eight studies were included in the review: four RCTs, three prospective studies, and one retrospective study. Seven of eight studies were favourable of UDCA for biliary pain. Outcomes and follow-up times were heterogenous, as well as comparator type, with only four of eight studies comparing with placebo.

Conclusion
Evidence for UDCA in symptomatic gallstones is scarce and heterogenous. Clinicians currently managing symptomatic gallstone disease are largely unaware of the benefit of UDCA, and there is clinical equipoise surrounding the benefit of UDCA. Level 1 evidence is required by clinicians to support UDCA use in the future.
Biliary drainage surgery before or after 3 months of life versus primary liver transplantation in children with biliary atresia: comparative cohort study
Authors: Fuchs Juri , Mrad Chaima , Gonzales Emmanuel , Ndiaye Dior , Fouquet Virginie , Héry Géraldine , Baujard Catherine , Guérin Florent , Branchereau Sophie 
Published: March 2023

Abstract

Background
Early biliary drainage surgery (BDS; Kasai) is associated with longer transplant-free survival in biliary atresia. However, evidence is lacking on whether an age limit can be established at which liver transplantation should be performed as first-line treatment for children with a delayed diagnosis of biliary atresia. The aim of the current study was to compare the outcome of a large cohort of children with biliary atresia who underwent BDS after 90 days of life with those who underwent early BDS (before 90 days) and those who did not receive BDS and were directly referred for primary liver transplantation.

Methods
All patients with biliary atresia treated at Bicêtre, Paris-Saclay University Hospital between 1995 and 2017 were analysed in this STROBE-compliant study. Three groups were defined: BDS before 90 days of life (early BDS); BDS after 90 days of life (late BDS); and patients without BDS who were referred for primary liver transplantation (no BDS). Patient characteristics, overall survival, and native liver survival were compared.

Results
Of 424 children with biliary atresia, 69 patients (16 per cent) were older than 90 days when they underwent BDS. Twenty-five patients had no BDS and were referred for primary liver transplantation (6 per cent). The main reason for not performing BDS was manifest portal hypertension (18/25). Two- and 5-year transplant-free survival were significantly higher in patients with late BDS compared with no BDS (53.5 versus 12.0 per cent respectively for 2-year data and 30.4 versus 4.0 per cent respectively for 5-year data, P &lt; 0.001). Five- and 10-year overall survival did not differ between early BDS (92 and 91 per cent respectively), late BDS (88 and 83 per cent respectively) and no BDS (80 and 80 per cent respectively, P = 0.061).

Conclusion
Age alone should not routinely be considered a contraindication to BDS in patients older than 90 days. Liver transplantation in infancy (less than 12 months) could be avoided in 88 per cent of cases with late diagnosis of biliary atresia and is delayed significantly even when BDS is performed after 3 months. Overall survival is at least equal to patients who are referred for primary liver transplantation.
Thermo-economic analysis of the performance of the combined system with evacuated tube collectors
Authors: Fadhil Smaisim Ghassan , Hadrawi Salema K , Abed Azher M , Majdi Hasan Sh. , Shamel Ali 
Published: March 2023

Abstract
Using combined cooling, heat and power systems can be an appropriate substitute for preventing emissions of pollutants and excessive consumption of fossil fuels. Utilizing renewable energy in these systems as a source of power generation can be an appropriate substitute for fossil-fuel-based systems. Therefore, in this paper, cogeneration cooling, heat and power systems based on gas-fired internal combustion engines with a solar-thermal system with evacuated tube collectors have been modelled and thermo-economic analysis has been done to compare fossil-fuel-based systems. The required rate of heat to supply the hot water is 50 kW. In the studied system, the internal combustion engine produces electrical energy. Then, the solar-thermal system with evacuated tube collectors and the gas-burning generator provide the thermal energy required by the studied building and the primary stimulus of the absorption chiller for cooling. In this study, two different scenarios are conducted in states considering simultaneous production systems and regardless of this environmental and thermo-economic analysis system. The results showed that the efficiency of the studied system was 60% in summer and 56% in winter.
Origin of hydrogen in aromatic and olefin products derived from (Al-) MCM-41 catalysed co-pyrolysis of glucose and polypropylene via isotopic labelling
Authors: Xue Junjie , Zhuo Jiankun , Wu Yifan , Jin Mingnuo , Sun Mufei , Yao Qiang 
Published: March 2023

AbstractCatalytic co-pyrolysis of biomass and plastic is an effective method to improve bio-oil produced by biomass pyrolysis. To further exploit the synergistic mechanism between biomass and plastic, co-pyrolysis of polypropylene (PP) and deuterated glucose (G) (1:1 wt%) over mesoporous catalysts MCM-41 (M) and Al-MCM-41(Al) was studied using a thermal gravimetric analyser (TGA) and pyrolysis–gas chromatography–mass spectrometry. The findings show that M and Al overlap the decomposition of PP and G, making synergy possible. With catalysts M and Al, the yield of olefins increases sharply to 36.75% and 13.66% more than the calculated value. Additionally, hydrogen transfers from G to 4C–13C olefins and aromatic products are influenced by the catalysts. Without a catalyst, there is no deuterium in all the co-pyrolytic products. However, catalysts M and Al can help transfer one to four deuterium atoms from G to the products. M and Al provide the pool for the intermediates of PP and G to form synergetic products. Additionally, Al helps break the carbon chain and transfer more deuterium into the products by reducing carbon atoms.
Multiple direct fetal amiodarone administration for supraventricular tachycardia with hydrops fetalis: a case report
Authors: Adenin Irvan , Kapnosa Hasani Rachmat Dediat 
Published: March 2023

AbstractBackgroundFetal supraventricular tachycardia (SVT) is the most common fetal tachyarrhythmia and can cause fetal heart failure and intrauterine death. The management varies within institution and usually based on published case series, institutional experience.Case summaryFetal SVT with hydrops (ascites and subcutaneous edema) was diagnosed at 26 weeks of gestational age. The first direct injection of fetal amiodarone into the umbilical vein resulted in temporary cardioversion to the sinus rhythm and mild transient maternal adverse event. The second direct fetal amiodarone to the fetal peritoneal cavity resulted in conversion to sinus rhythm, resolution of fetal hydrops, and normal fetal growth until delivery at 39 weeks gestational age.DiscussionTreatment of fetal SVT often requires prolonged maternal antiarrhythmic treatment and carries a significant risk of maternal adverse events. Direct fetal antiarrhythmic treatment often requires achieving adequate therapeutic drugs, especially in hydropic fetus. Amiodarone is one of drugs options for fetal SVT with hydrops because it has been shown to be highly effective with low fetal mortality. Continuous vital sign and ECG monitoring should be performed during direct fetal antiarrhythmic administration.
Impact of the antiplatelet strategy following patent foramen ovale percutaneous closure
Authors: Guedeney Paul , Farjat-Pasos Julio I , Asslo Gabriel , Roule Vincent , Beygui Farzin , Hermida Alexis , Gabrion Paul , Leborgne Laurent , Houde Christine , Huang Florent , Lattuca Benoit , Leclercq Florence , Mesnier Jules , Abtan Jérémie , Rouanet Stéphanie , Hammoudi Nadjib , Collet Jean-Philippe , Zeitouni Michel , Silvain Johanne , Montalescot Gilles , Rodés-Cabau Josep ,   for the AIR-FORCE Task Force
Published: March 2023

ABSTRACTAimsTemporary dual antiplatelet therapy (DAPT) is recommended following patent foramen ovale (PFO) percutaneous closure although its benefit, compared to single antiplatelet therapy (SAPT), has not been demonstrated in this setting. We aimed at assessing outcomes following PFO closure according to the antiplatelet strategy at discharge.Methods and resultsThe ambispective AIR-FORCE cohort included consecutive patients from seven centres in France and Canada undergoing PFO closure and discharged without anticoagulation. Patients treated in French and Canadian centres were mostly discharged with DAPT and SAPT, respectively. The primary endpoint was the composite of death, stroke, transient ischaemic attack, peripheral embolism, myocardial infarction, or BARC type ≥2 bleeding with up to 5 years of follow-up. The impact of the antiplatelet strategy on outcomes was evaluated with a marginal Cox model (cluster analyses per country) with inverse probability weighting according to propensity score. A total of 1532 patients (42.2% female, median age: 49 [40–57] years) were included from 2001 to 2022, of whom 599 (39.1%) were discharged with SAPT and 933 (60.9%) with DAPT, for ≤3 months in 894/923 (96.9%) cases. After a median follow-up of 2.4 [1.1–4.4] years, a total of 58 events were observed. In the weighted analysis, the rate of the primary endpoint up to 5 years was 7.8% in the SAPT strategy and 7.3% in the DAPT strategy (weighted hazard ratio 1.04, 95% confidence interval 0.59–1.83).ConclusionThe antiplatelet strategy following PFO closure did not seem to impact clinical outcomes, thus challenging the current recommendations of temporary DAPT.
Avoiding misleading estimates using mtDNA heteroplasmy statistics to study bottleneck size and selection
Authors: Giannakis Konstantinos , Broz Amanda K , Sloan Daniel B , Johnston Iain G 
Published: March 2023

Abstract
Mitochondrial DNA heteroplasmy samples can shed light on vital developmental and genetic processes shaping mitochondrial DNA populations. The sample means and sample variance of a set of heteroplasmy observations are typically used both to estimate bottleneck sizes and to perform fits to the theoretical “Kimura” distribution in seeking evidence for mitochondrial DNA selection. However, each of these applications raises problems. Sample statistics do not generally provide optimal fits to the Kimura distribution and so can give misleading results in hypothesis testing, including false positive signals of selection. Using sample variance can give misleading results for bottleneck size estimates, particularly for small samples. These issues can and do lead to false positive results for mitochondrial DNA mechanisms—all published experimental datasets we re-analyzed, reported as displaying departures from the Kimura model, do not in fact give evidence for such departures. Here we outline a maximum likelihood approach that is simple to implement computationally and addresses all of these issues. We advocate the use of maximum likelihood fits and explicit hypothesis tests, not fits and Kolmogorov–Smirnov tests via summary statistics, for ongoing work with mitochondrial DNA heteroplasmy.
Aminoacyl-tRNA Synthetase Evolution within the Dynamic Tripartite Translation System of Plant Cells
Authors: Sloan Daniel B , DeTar Rachael A , Warren Jessica M 
Published: March 2023

AbstractEukaryotes maintain separate protein translation systems for nuclear and organellar genes, including distinct sets of tRNAs and aminoacyl-tRNA synthetases (aaRSs). In animals, mitochondrial-targeted aaRSs are expressed at lower levels and are less conserved in sequence than cytosolic aaRSs involved in translation of nuclear mRNAs, likely reflecting lower translational demands in mitochondria. In plants, translation is further complicated by the presence of plastids, which share most aaRSs with mitochondria. In addition, plant mitochondrial tRNA pools have a dynamic history of gene loss and functional replacement by tRNAs from other compartments. To investigate the consequences of these distinctive features of translation in plants, we analyzed sequence evolution in angiosperm aaRSs. In contrast to previously studied eukaryotic systems, we found that plant organellar and cytosolic aaRSs exhibit only a small difference in expression levels, and organellar aaRSs are slightly more conserved than cytosolic aaRSs. We hypothesize that these patterns result from high translational demands associated with photosynthesis in mature chloroplasts. We also investigated aaRS evolution in Sileneae, an angiosperm lineage with extensive mitochondrial tRNA replacement and aaRS retargeting. We predicted positive selection for changes in aaRS sequence resulting from these recent changes in subcellular localization and tRNA substrates but found little evidence for accelerated sequence divergence. Overall, the complex tripartite translation system in plant cells appears to have imposed more constraints on the long-term evolutionary rates of organellar aaRSs compared with other eukaryotic lineages, and plant aaRS protein sequences appear largely robust to more recent perturbations in subcellular localization and tRNA interactions.
Coseismic and post-seismic characteristics of the 2021 Ganaveh earthquake along the Zagros foredeep fault based on InSAR data
Authors: Jafari Mahin , Aflaki Mahtab , Mousavi Zahra , Walpersdorf Andrea , Motaghi Khalil 
Published: March 2023

SUMMARY
The Ganaveh earthquake on 2021 April 18 (Mw 5.8) occurred in the southwest of the Dezful embayment of the Zagros Mountain belt, Iran, as a mainly compressive event. The InSAR coseismic displacement maps reveal a maximum of 17 cm of surface displacement in the satellite line of sight direction. InSAR inversion indicates a low-angle NE-dipping causative fault plane with a maximum slip of 95 cm at ∼6 km depth. It highlights the occurrence of the Ganaveh earthquake within the competent layers of the Zagros sedimentary cover, beneath the Gachsaran formation. A slight sinistral slip component (2.9 cm) is retrieved which is compatible with the USGS focal mechanism. Time-series analysis of SAR images after the main shock until the end of 2021 indicates a maximum of 7 cm of post-seismic surface displacement with a similar strike and pattern as the coseismic phase. This similarity and the distribution of aftershocks suggest an afterslip mechanism for the post-seismic phase. The inversion of post-seismic cumulative displacement evaluates a maximum of 30 cm slip at a depth of ∼5 km along the coseismic causative fault. A regional compressional stress regime (N041°E for the direction of the σ1 stress axis) is constrained by using the focal mechanisms of 39 earthquakes occurring between 1968 and 2021, including the Ganaveh main shock and its five larger aftershocks. Applying this direction of compression on the Ganaveh fault plane also results in a minor sinistral movement, consistent with the geodetic results. The relocated main shock and aftershocks as well as our InSAR coseismic displacement situations on the hanging wall of the Zagros Foredeep fault highlight it as the causative fault of the Ganaveh earthquake. To fit the geometry of the Ganaveh rupture plane with the Zagros Foredeep fault, we modelled a listric fault plane and its slip distribution using the available geological data. The retrieved slip variation on the listric plane is in close agreement with the slip pattern on the modelled planar geometry. The low dip angle of the rupture plane combined with a listric geometry highlights the thin-skin characteristics of the Zagros Foredeep fault as the causative fault of the Ganaveh earthquake. The occurrence of this moderate magnitude earthquake on the Zagros Foredeep fault underlines its role as the western structural boundary for the recurrence of Mb &gt; 5 events in the Dezful embayment.
The Holy Cross Mountains (Poland) terranes palaeoposition and depositional environment in Silurian—new insights from rock magnetic studies
Authors: Niezabitowska D K , Szaniawski R 
Published: March 2023

SUMMARY
The Holy Cross Mountains (HCM) in Poland, is an isolated natural outcrop of Palaeozoic rocks located within the Trans-European Suture Zone, a tectonic collage of continental terranes adjacent to the Tornquist margin of the Baltica. This uniqueness made the HCM a target for palaeogeographic research. Based on the facies differences, the HCM had been divided into two major units, the southern (the Kielce Unit) and northern (the Łysogóry Unit) part (SHCM and NHCM, respectively). Their position in relation to each other and the Baltica continent during Silurian times is still a matter of discussion, whether both parts of the HCM were separated terranes located along the Baltica margin or they shared in common palaeogeographic history. Here, we present the results of comprehensive rock magnetic measurements applied as a tool to interpret palaeoenvironmental conditions during deposition and burial and therefore allow discussion about the terranes’ relative position. To recognize the magnetic mineral composition and texture of studied Silurian graptolitic shales several rock magnetic measurements were conducted including low-temperature Saturated Isothermal Remanent Magnetization, thermal demagnetization of three-component IRM and hysteresis measurements, as well as anisotropy of magnetic susceptibility (AMS). The sampled rocks come from both units of the HCM. In all analysed samples we found single domain (SD) stoichiometric magnetite of mostly diagenetic (i.e. post-depositional) origin and goethite resulting likely from weathering. In turn, detrital magnetite, even if observed in previously investigated Silurian rocks from the Baltica margin, was not identified in this study, what we attribute to dissolution during diagenesis in the deep-water environment. Solely in the NHCM, SD hematite and maghemite grains were observed, which we interpret as detrital in origin. These grains have been preserved in the suboxic environment of the NHCM sub-basin bottom waters due to their resistance to dissolution in marine waters. Considering the deposition conditions (oxygenation of the near-bottom zone) rather similar for both HCM parts, we associate the presence of aeolian hematite grains solely in the NHCM rocks with a more proximal position of the NHCM than the SHCM in relation to the Baltica continent during late Llandovery (Silurian). This conclusion agrees with some existing palaeogeographic models. In addition to petromagnetic studies focused on the analysis of ferromagnets, AMS measurements were also carried out. The results indicate that the magnetic susceptibility is mainly governed by paramagnetic minerals, mostly phyllosilicates with small ferromagnetic contributions. Oblate AMS ellipsoid and distinct bedding parallel foliation indicate prevailing sedimentary-compactional alignment. Observed magnetic lineation of tectonic origin resulting from weak strain is related presumably to Variscian deformations.
The nursing home as a hub: boundary work as a key to community health promotion
Authors: Wegener Charlotte , Storm Marianne , Willumsen Elisabeth 
Published: March 2023

SummaryThis article considers ways in which a nursing home can come to serve as a hub for community health promotion. Inspired by the term ‘boundary crossing’ (Akkerman and Bakker. Boundary crossing and boundary objects. Rev Educ Res 2011;81:132–69), we suggest the notion of ‘boundary work’ to illustrate how a nursing home arranges community activities and includes a wide range of participants. In health research, a ‘hub’ refers to a space in which activities and expertise are ‘bound together’ over time. The concept of the hub indicates that health organizations have the power to become centres for health promotion by initiating new collaborations and opening up initiatives in two-way processes with the local community. The term ‘boundary work’ supports a perspective that dissolves organizational, professional and conceptual boundaries and directs attention towards social inclusion as a key to community health promotion in and beyond institutionalized elderly care. The article is based on a 4-year-long practice-based study of social innovation in elderly care in Norway and Denmark. Empirical illustrations show boundary work in which a nursing home comes to serve as a hub. We discuss a flexible framework for understanding, mapping and planning participatory approaches for health and wellbeing (South et al. An evidence-based framework on community-centred approaches for health: England, UK. Health Promot Int 2019;34:356–66) and briefly connect these approaches to the concept of social innovation as a possible future research path.