bluuebunny/crossref_metadata_2025_split huggingface dataset:
BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROS
Authors: Guo Xiao , Zhu Yuemeng , Guo Lu , Qi Yiwen , Liu Xiaocheng , Wang Jinhui , Zhang Jiangtao , Cui Linlin , Shi Yueyang , Wang Qichu , Liu Cenxi , Lu Guangxing , Liu Yilian , Li Tao , Hong Shangyu , Qin Yingying , Xiong Xuelian , Wu Hao , Huang Lin , Huang He , Gu Chao , Li Bin , Li Jin 
Published: February 2023

AbstractPremature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle‐stimulating hormone. Though POI affects many aspects of women's health, its major causes remain unknown. Many clinical studies have shown that POI patients are generally underweight, indicating a potential correlation between POI and metabolic disorders. To understand the pathogenesis of POI, we performed metabolomics analysis on serum and identified branch‐chain amino acid (BCAA) insufficiency‐related metabolic disorders in two independent cohorts from two clinics. A low BCAA diet phenotypically reproduced the metabolic, endocrine, ovarian, and reproductive changes of POI in young C57BL/6J mice. A mechanism study revealed that the BCAA insufficiency‐induced POI is associated with abnormal activation of the ceramide‐reactive oxygen species (ROS) axis and consequent impairment of ovarian granulosa cell function. Significantly, the dietary supplement of BCAA prevented the development of ROS‐induced POI in female mice. The results of this pathogenic study will lead to the development of specific therapies for POI.
KARAKTERISTIK ASPEK KESEHATAN LINGKUNGAN DAN PERILAKU PASIEN COVID-19 DALAM PELAKSANAAN ISOLASI MANDIRI
Authors: Pawenang Eram Tunggul , Wijayanti Yuni , Siwiendrayanti Arum 
Published: February 2023

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) adalah penyebab penyakit baru yang dikenal dengan nama COVID-19. Perpindahan SARS-CoV-2 dapat terjadi melalui singgungan tidak berjarak dengan orang yang positif terinfeksi, sehingga perlu isolasi mandiri untuk membatasi kontak. Isolasi mandiri di rumah sangat dianjurkan untuk individu yang diyakini telah terpapar COVID-19, baik tanpa gejala maupun dengan gejala ringan. Studi ini bertujuan untuk melihat karakteristik segi kesehatan lingkungan, dan tingkah laku pasien isolasi mandiri COVID-19 yang terdata di Puslakes UNNES. Penelitian menggunakan jenis deskriptif kuantitatif dengan menggunakan pendekatan potong lintang. Pemilihan sampel responden menggunakan total sampling dan di dapatkan pasien COVID-19 yang melakukan isolasi mandiri sebanyak 73 pasien. Instrumen yang digunakan adalah kuesioner. Penelitian memberikan hasil pada aspek lingkungan menunjukkan fasilitas sanitasi responden mayoritas baik (95,5%), diikuti desinfeksi (76,7%), kamar tidur memenuhi syarat (75,3%), pengelolaan limbah memenuhi syarat (69,9%), dan kamar mandi memenuhi syarat (64,4%). Berdasarkan aspek perilaku, responden dengan perilaku baik sebesar 54,8%, termasuk dalam kategori yang rendah karena yang baik minimal 80%. Terdapat hubungan antara aspek lingkungan desinfeksi dengan perilaku isoman yang baik pada responden yang terdata di Puslakes UNNES (p value 0,016).
Eosinophilic Granulomatosis with Polyangiitis in an 8-year-old Girl Manifesting as Hypereosinophilic Syndrome with Myocarditis, Stroke, and Subsequent Orbital Involvement
Authors: Paņina Aleksandra , Ligere Elīna , Aleksejeva Elīna , Davidsone Zane , Cebura Elizabete , Erdmane Irina 
Published: February 2023

Hypereosinophilic syndrome (HES) is a heterogeneous group of disorders characterized by peripheral blood eosinophilia of 1.5 × 109/L (1,500/μL) or greater, with evidence of end-organ damage attributable to eosinophilia (e.g., heart, liver or lung) with no other cause for the end-organ damage [1]. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disorder that may affect multiple organ systems (lungs, heart, kidneys, or the nervous system). The disorder is characterized by hypereosinophilia in the blood and tissues, inflammation of blood vessels (vasculitis), and the development of inflammatory nodular lesions called granulomatosis [2]. We report a case with a 9-year-old girl presenting with severe hypereosinophilia, ischemic stroke, right-sided hemiparesis and myocarditis treated with methylprednisolone, enoxaparin, rivaroxaban and carvedilol. The patient recovered successfully from myocarditis and stroke but manifested with right-sided orbital involvement as pre- and post-septal orbital cellulitis 10 months later with necrotizing granulomatous perivascular chronic infiltration with eosinophilic infiltration treated with methylprednisolone and subsequent mepolizumab with successful remission of orbital involvement, but severe exogenous Cushing’s syndrome and myocardial fibrosis.
O verdadeiro desafio do TikTok
Authors: Coelho Renato Arnellas 
Published: February 2023

O homem, pela sua própria natureza, busca diversos meios de interação social ao longo de sua vida. Recentemente, o crescente número de usuários do aplicativo TikTok não passa desapercebido pela Igreja que vê em tudo uma oportunidade para evangelizar. A cada nova geração é missão da Igreja transmitir o evangelho às novas pessoas que chegam a este mundo. No contexto atual, as gerações mais jovens estão cada vez mais conectadas nas redes sociais e, após a pandemia de 2020, muitos jovens aderiram ao uso do aplicativo TikTok como meio de entretenimento pessoal e de interação social para aliviar as tensões geradas pela situação atípica de isolamento generalizado. Apesar do TikTok não ter sido criado como meio de evangelização, mas de diversão, cabe à Igreja vencer esse verdadeiro desafi o e conseguir com sua fecunda criatividade transmitir sua mensagem nesses novos locais em que as pessoas se encontram, precisando para isso conhecer melhor seus potenciais e limitações, bem como fugir de eventuais perigos que as novas tecnologias podem apresentar. Para tanto, certos princípios e orientações já tratados no documento de Medellín podem ajudar a fornecer pistas para esse novo meio de comunicação social chamado TikTok.
Teaching retirees life adjustment pattern for lifelong educational service delivery in Rivers State, Nigeria
Authors: Eseyin Emmanuel Olorunleke , Eseyin Chisom Ure 
Published: February 2023

AbstractEvery year, several teachers retire from the education sector in Rivers State and these teaching retirees still have a lot they can contribute to the education system but can only deliver lifelong educational services when life after retirement is patterned to what is obtainable during active service. The study investigated teaching retirees' life adjustment pattern for lifelong educational service delivery in Rivers State. The study's design was descriptive survey and 18,073 retirees formed the population of the study out of which 391 retirees were sampled through multistage sampling. Data were collected using questionnaire which was face and content validated by experts in University of Port Harcourt with a Cronbach alpha determined reliability index of 0.94. Answers were provided to the research questions using mean score and SD while at 5% level of significance the hypotheses were tested using z-test statistics. The study revealed that retired teachers adjust economically using different patterns including engaging in paid employment. The retirees also adjusted socially through different patterns. Conclusively, the study identified that the retirees had economic and social adjustment patterns needed for providing lifelong educational services in Rivers State.
Intermittent cold exposure upregulates regulators of cardiac mitochondrial biogenesis and function in mice
Authors: Mohan Mithra Sudha , Sreedevi Aswani Sukumaran , Sakunthala Aparna Nandakumaran , Boban Puthenpura T. , Sudhakaran Perumana R. , Kamalamma Saja 
Published: February 2023

AbstractHypothermic conditions enhance the incidence of cardiovascular diseases due to increased blood pressure. Cold-induced adaptive thermogenesis increased mitochondrial biogenesis and function in skeletal muscles and adipocytes. Here, we studied the effect of intermittent cold exposure on the regulators of cardiac mitochondrial biogenesis, function, and its regulation by SIRT-3. Intermittent cold exposed mice hearts showed normal histopathology with increased mitochondrial antioxidant and metabolic function, as evidenced by an increase in the activity and expression of MnSOD and SDH. A substantial increase in mitochondrial DNA copy number and increase in the expression of PGC-1α and its downstream targets NRF-1 and Tfam indicated the possibility of enhanced cardiac mitochondrial biogenesis and function on intermittent cold exposure. Increased mitochondrial SIRT-3 level and decreased total protein lysine acetylation indicate increased sirtuin activity in cold exposed mice hearts. Ex vivo cold mimic using norepinephrine showed a significant increase in PGC-1α, NRF-1, and Tfam levels. AGK-7, a SIRT-3 inhibitor, reversed the norepinephrine-induced upregulation of PGC-1α and NRF-1, indicating the role of SIRT-3 on the production of PGC-1α and NRF-1. Inhibition of PKA with KT5720 in norepinephrine treated cardiac tissue slices indicates the role of PKA in regulating the production of PGC-1α and NRF-1. In conclusion, intermittent cold exposure upregulated the regulators of mitochondrial biogenesis and function through PKA and SIRT-3 mediated pathway. Our results emphasize the role of intermittent cold-induced adaptive thermogenesis in overcoming chronic cold-induced cardiac damage.
In Search of a Feminist Theory of Expression
Authors: Ascarate Luz 
Published: February 2023

In the Tractactus Logico Philosophicus, Wittgenstein concludes that what cannot be spoken about is better left unsaid, which would correspond to everything that is not scientific language susceptible of being formalized in the propositional framework. It is not until Philosophical Investigations that he will find the formula of the “expression” taken in an encompassing sense with its notion of “seeing aspects”. For his part, in his course “Le problème de la parole”, Merleau-Ponty, elaborates a reflection on language that begins with the consideration of the scientific and logical naivety of language, in relation to Saussure's linguistics, and ends with the comparison between Proust and Stendhal. In this last part, he proposes that literature, as a creative language and an expressive operation, is both true life, connected with the ontological foundation of what exists, and phenomenology that shows the institution of that life. In both authors, the logical consideration is overwhelmed by the expressive power of language. Our contribution will make a comparison between Wittgenstein's and Merleau-Ponty's reflections on language and expressiveness. With this, we will seek to propose the bases of a feminist theory of expression, that is, a theory that seeks to show the particularity of female expressiveness.
Wittgenstein and Feminism: Alice Crary in Conversation with Mickaëlle Provost
Authors: Provost Mickaëlle , Crary Alice 
Published: February 2023

Alice Crary is a moral and social philosopher who has written widely on issues in metaethics, moral psychology and normative ethics, philosophy and feminism, critical animal studies, critical disability studies, critical philosophy of race, philosophy and literature, and Critical Theory. She has written on philosophers such as John L. Austin, Stanley Cavell, Cora Diamond, John McDowell, Iris Murdoch and Ludwig Wittgenstein. This is the first of two parts of the interview with Crary conducted in a single exchange in the first weeks of January 2022, where she discusses ordinary language philosophy and feminism, Wittgenstein’s conception of mind and its relation to feminist ethics, the link between Wittgenstein and Critical Theory, and her own views about efforts to bring about social and political transformations. The second part on “Wittgenstein and Critical Theory” is published in the regular volume 11 of NWR.
Tractatus Logico-Philosophicus
Authors: Wittgenstein Ludwig 
Published: February 2023

Tractatus Logico-Philosophicus by Ludwig Wittgenstein: Three parallel tree-structured editions. (1) Tree-structured arrangement of the German text, edited by David G. Stern, Joachim Schulte and Katia Saporiti. (2) Tree-structured arrangement of the English translation by Ogden and Ramsey, edited by David G. Stern. (3) Tree-structured arrangement of the English translation by Pears and McGuinness, edited by David G. Stern.
PANDEMİ DÖNEMİNDE AMELİYATHANE ÇALIŞANLARINDA TÜKENMİŞLİĞİN DEĞERLENDİRİLMESİ
Authors: KURT Devrim Tanıl , ÇAKIRCA Müge 
Published: February 2023

Amaç
Koronavirüs pandemisiyle birlikte genelde tüm sağlık
çalışanları, özelde de ameliyathane personelleri zor
şartlarla çalışmak zorunda kaldılar. Bu çalışmanın
amacı, ameliyathane çalışanlarında tükenmişlik seviyelerini
incelemektir.
Gereç ve Yöntem
Şubat 2021’de ameliyathanede çalışan 162 sağlık
çalışanına Kopenhag tükenmişlik ölçeği uygulandı.
Katılımcıların kişisel, iş ve pandemi ile ilişkili olmak
üzere üç alt başlıkta tükenmişlik seviyeleri ölçüldü. 50
puan üzerinde skorlar yüksek tükenmişlik olarak kabul
edildi.
Bulgular
Kişisel tükenmişlik 66.9±19.5, iş ile ilgili tükenmişlik
66.8 ± 16.1, pandemi ile ilişkili tükenmişlik 74.3± 12.1
olarak bulundu. Tüm alt ölçekler için kadın cinsiyette
olanların daha yüksek skora sahip oldukları bulundu.
Sonuç
Ameliyathane çalışanlarının pandemi dönemindeki
tükenmişlik düzeyleri yüksek seviyelerde tespit edilmiştir.
Tükenmişliği azaltacak veya önleyecek eylemlere
bu konuda ihtiyaç bulunmaktadır.
EXCESSIVE USE OF FLAXSEED MAY POSE A THREAT TO KIDNEY TISSUE: AN EXPERIMENTAL STUDY
Authors: ARMAĞAN İlkay , YEŞİLOT Şükriye 
Published: February 2023

Objective
We aimed to investigate the effects of flaxseed,
which is widely used due to its healing effects, on the
kidney tissue when the daily recommended dose is
exceeded.
Material and Methods
We divided the male Wistar Albino rats into four
groups of eight, namely the control, OD-1 (1.4 mg/
kg/d), OD-2 (2.8 mg/kg/d), and OD-3 (5.6 mg/kg/d)
groups. Ground flaxseed was administered to each
overdose group by oral gavage for 7 days. At the
end of the experiment, blood and kidney samples
were collected. Blood samples were centrifuged and
serum was separated for renal function analyses.
The half of the kidney samples were stored at -20
°C until biochemical analyses and we fixed the
remaining tissues with 10% buffered formalin for
histopathological analysis.
Results
Serum urea and BUN levels were significantly
increased in all overdose groups compared to the
control group (for all p˂0.05). TAS levels significantly
decreased in the OD-3 group compared to the control
(p=0.044). There was an increase renal TOS levels
in all overdose groups compared to the control
and also, OSI level of the OD-3 group significantly
increased compared to the control (p=0.016). While
histopathological changes were not observed in OD-1
and OD-2 groups compared to the control group,
there were non-significant histopathological changes
in OD-3 group.
Conclusion
It was concluded that the use of flaxseed above the
recommended daily dose can pose a threat to kidney
tissue. So, while being used for its benefit, in order not
to be exposed to its toxic effects, overuse and longterm
use should be avoided.
One-stage revision reconstruction of the anterior cruciate ligament using autograft: retrospective cohort study
Authors: Butkova Lyudmila L. , Orletsky Anatoly K. 
Published: February 2023

BACKGROUND: Revision reconstruction of the anterior cruciate ligament (ACL) is a technically more complex procedure than primary reconstruction. Recurrence of anterior instability is most often associated with a technical error during the primary operation. The primary task of revision reconstruction is to identify the cause of recurrence of anterior instability and careful preoperative planning. Thus, the principles of ACL anatomical location to be essential restore stability. This paper discusses options for revision anatomical reconstruction of the ACL, including surgical technique, preoperative preparation, and choice of autograft material.
AIM: This study aimed to evaluate the results of a one-stage revision reconstruction of the ACL and show that this method can be performed in one stage, rather than in two stages, which will lead to a reduction in the patients recovery time and return to usual physical activity.
MATERIALS AND METHODS: To monitor the long-term treatment results, 50 of 92 patients with revision through one-stage ACL reconstruction, who were examined 9, and 12 months after surgery, were enrolled. All patients were young, who were working from age 18 to 42 years. The mean age was 29 years. This group included only male patients. As a graft material, all patients underwent sampling of the tendons of the fine and semitendinous muscles from the diseased or the contralateral limb. To assess the treatment results, the IKDC scale, Lysholm scale, arthrometric testing on KT-1000, and functional tests were conducted.
RESULTS: The use of developed surgical approaches made it possible to obtain good treatment results in patients with recurrences of anterior instability according to the Lysholm score of 82 points. Grade II residual lateral instability was observed in two (4%) patients in the observed group and in seven (14%) patients in the control group. According to the subjective assessment of treatment outcomes, 19 patients (38%) remained satisfied with them.
CONCLUSION: The practical application of the proposed options for the location of the channels and methods for fixing the autograft in the intraosseous channels make it possible to perform revision arthroscopic reconstruction of the ACL in one stage, without additional bone grafting of the channels, which in turn reduces the treatment and recovery time of patients, as evidenced by the results.
The Damage Assessment for Rapid Response (DARR) Method and its Application to Different Ground-Motion Levels and Building Types
Authors: Petrovic Bojana , Scaini Chiara , Parolai Stefano 
Published: February 2023

AbstractSeismic recordings in buildings and on the ground are increasingly available due to the increment and expansion of seismic monitoring networks worldwide. However, most urban strong-motion networks consist of stations installed at the ground or, less frequently, in selected building’s basement. It is, therefore, of utmost importance to develop methods that can provide estimates of expected structural damage, starting from earthquake recordings at the ground level. Damage Assessment for Rapid Response (DARR) provides first-level estimates of the expected damage to buildings, based on ground-motion recordings and simple information on buildings’ characteristics. In this work, we apply DARR using both weak and strong ground-motion recordings available for different low- and mid-rise building typologies. A total of 9 buildings and 19 earthquake recordings were analyzed. DARR reproduces the shaking at the building’s top, and estimates the peak structural relative displacement or average interstory drift. Results show that the method works well for the considered building types and ground-motion levels for the estimation of relative and total displacements using first-order assessments. Comparison with the previously defined thresholds allows the estimation of expected damage. Our results (i.e., no damage for most buildings and events) are consistent with the absence of damaging events in northeastern Italy in the studied period (2019–2021). For a school building in central Italy, which was heavily damaged by the 2016 Central Italian sequence, DARR correctly predicted this fact.
SETAS: A Spherical Version of the Space–Time ETAS Model
Authors: Xiong Ziyao , Zhuang Jiancang 
Published: February 2023

AbstractTo analyze and forecast seismicity globally or in high-latitude regions, and particularly in relation to remote seismicity interactions on a worldwide scale, we reformulate the space–time epidemic-type aftershock sequence (ETAS) model from a planar to a spherical version and implement it in a FORTRAN software package, spherical ETAS (SETAS). This article explains the details of the related algorithms and the usage of the package, which can fit the SETAS model to seismicity data from regions specified by three types of boundaries: no, quadrilateral, and spherical polygon boundaries. The software is tested with the Global Centroid Moment Tensor (Global CMT) catalog and compared to the original planar ETAS model by fitting both the versions to local seismicity in Japan and Alaska. The results show that the spherical model has a high computational efficiency, even with a large range of global data, and is consistent with the well-established planar version at the local scale.
RMC: Red Metodológica de Confianza
Authors: Lozano Correa Luz Janeth , Pérez Uribe Rafael Ignacio , Andrade Valbuena Nelson Andrés 
Published: February 2023

Este artículo presenta los conceptos relacionados con el constructo “confianza” y su importancia para cohesionar los esfuerzos necesarios para obtener los objetivos organizacionales, principalmente cuando se trata de la relación entre la alta gerencia y sus inmediatos colaboradores. Para conceptualizar la confianza entre jefes y colaboradores se realizó una investigación entre los años 2017 y 2018 en 224 medianas empresas ubicadas en Bogotá, D.C. - Colombia, que permitió construir y formular la “Red Metodológica de Confianza (RMC)”, en la cual se caracterizan las “dimensiones, variables e ítems” que muestran el nivel de las relaciones de confianza entre ellos (jefes y colaboradores) en una organización. A partir del total de las empresas medianas listadas en la base de datos del año 2017 de la superintendencia de sociedades, se realizó “intencionalmente un muestreo aleatorio simple con distribución de acuerdo con el tamaño, donde los elementos de la muestra (empresas) se seleccionaron de modo aleatorio” (Lozano-Correa, 2021, p.84). Para compilar la información en las empresas “se realizó un trabajo de campo que consistió en la aplicación de la metodología de prospectiva de MIC-MAC (Matriz de Impactos Cruzados Multiplicación Aplicada a una Clasificación)” (Pérez-Uribe y Vargas, 2016). Se hizo un análisis factorial con los datos arrojados y para estudiar su relación se trabajó con el análisis multivariado de regresión múltiple con el paquete estadístico “StatGraphics Centurion”, “con el cual se analizaron simultáneamente medidas múltiples de cada ítem sometido en la investigación” (Lozano-Correa, 2021, pp. 83 y 84). Se trabajaron tres hipótesis, de las cuales se comprobaron dos de ellas. Todo este trabajo les permitió a los investigadores autores de este articulo proponer un modelo para medir la confianza y sus componentes, que facilita el análisis del nivel en que se encuentran las dimensiones, variables e ítems en una organización, con lo cual se puede formular un plan de fortalecimiento para llevar a la organización a ejecutar las mejores acciones para el manejo de los constructos de la Red Metodológica de Confianza.