bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absolute risks of self-harm and interpersonal violence by diagnostic category following first discharge from inpatient psychiatric care
Authors: Mok P. L. H. , Walter F. , Carr M. J. , Antonsen S. , Kapur N. , Steeg S. , Shaw J. , Pedersen C. B. , Webb R. T. 
Published: January 2023

Abstract

Background
Persons discharged from inpatient psychiatric services are at greatly elevated risk of harming themselves or inflicting violence on others, but no studies have reported gender-specific absolute risks for these two outcomes across the spectrum of psychiatric diagnoses. We aimed to estimate absolute risks for self-harm and interpersonal violence post-discharge according to gender and diagnostic category.

Methods
Danish national registry data were utilized to investigate 62,922 discharged inpatients, born 1967–2000. An age and gender matched cohort study was conducted to examine risks for self-harm and interpersonal violence at 1 year and at 10 years post-discharge. Absolute risks were estimated as cumulative incidence percentage values.

Results
Patients diagnosed with substance misuse disorders were at especially elevated risk, with the absolute risks for either self-harm or interpersonal violence being 15.6% (95% CI 14.9, 16.3%) of males and 16.8% (15.6, 18.1%) of females at 1 year post-discharge, rising to 45.7% (44.5, 46.8%) and 39.0% (37.1, 40.8%), respectively, within 10 years. Diagnoses of personality disorders and early onset behavioral and emotional disorders were also associated with particularly high absolute risks, whilst risks linked with schizophrenia and related disorders, mood disorders, and anxiety/somatoform disorders, were considerably lower.

Conclusions
Patients diagnosed with substance misuse disorders, personality disorders and early onset behavioral and emotional disorders are at especially high risk for internally and externally directed violence. It is crucial, however, that these already marginalized individuals are not further stigmatized. Enhanced care at discharge and during the challenging transition back to life in the community is needed.
Cell-Free DNA as a Diagnostic and Prognostic Biomarker in Pediatric Rhabdomyosarcoma
Authors: Lak Nathalie S.M. , van Zogchel Lieke M.J. , Zappeij-Kannegieter Lily , Javadi Ahmad , van Paemel Ruben , Vandeputte Charlotte , De Preter Katleen , De Wilde Bram , Chicard Mathieu , Iddir Yasmine , Schleiermacher Gudrun , Ruhen Olivia , Shipley Janet , Fiocco Marta , Merks Johannes H.M. , van Noesel Max M. , van der Schoot C. Ellen , Tytgat Godelieve A.M. , Stutterheim Janine 
Published: January 2023

PURPOSE Total cell-free DNA (cfDNA) and tumor-derived cfDNA (ctDNA) can be used to study tumor-derived genetic aberrations. We analyzed the diagnostic and prognostic potential of cfDNA and ctDNA, obtained from pediatric patients with rhabdomyosarcoma. METHODS cfDNA was isolated from diagnostic plasma samples from 57 patients enrolled in the EpSSG RMS2005 study. To study the diagnostic potential, shallow whole genome sequencing (shWGS) and cell-free reduced representation bisulphite sequencing (cfRRBS) were performed in a subset of samples and all samples were tested using droplet digital polymerase chain reaction to detect methylated RASSF1A ( RASSF1A-M). Correlation with outcome was studied by combining cfDNA RASSF1A-M detection with analysis of our rhabdomyosarcoma-specific RNA panel in paired cellular blood and bone marrow fractions and survival analysis in 56 patients. RESULTS At diagnosis, ctDNA was detected in 16 of 30 and 24 of 26 patients using shallow whole genome sequencing and cfRRBS, respectively. Furthermore, 21 of 25 samples were correctly classified as embryonal by cfRRBS. RASSF1A-M was detected in 21 of 57 patients. The presence of RASSF1A-M was significantly correlated with poor outcome (the 5-year event-free survival [EFS] rate was 46.2% for 21 RASSF1A-M ‒positive patients, compared with 84.9% for 36 RASSF1A-M ‒negative patients [ P < .001]). RASSF1A-M positivity had the highest prognostic effect among patients with metastatic disease. Patients both negative for RASSF1A-M and the rhabdomyosarcoma-specific RNA panel (28 of 56 patients) had excellent outcome (5-year EFS 92.9%), while double-positive patients (11/56) had poor outcome (5-year EFS 13.6%, P < .001). CONCLUSION Analyzing ctDNA at diagnosis using various techniques is feasible in pediatric rhabdomyosarcoma and has potential for clinical use. Measuring RASSF1A-M in plasma at initial diagnosis correlated significantly with outcome, particularly when combined with paired analysis of blood and bone marrow using a rhabdomyosarcoma-specific RNA panel.
Fashion’s Borders
Authors: Garrity Jane , Marshik Celia 
Published: January 2023

Abstract
The introduction traces the long history of fashion’s movement across cultural, national, and political borders. After brief case studies of early twentieth-century French and Spanish styles imagining fashion as an engine of transnational amity, the introduction highlights how fashion navigates some of the most troubled borders of recent years, including the conflict between Russia and Ukraine and racial violence. Fashion forces viewers and consumers to choose sides, whether through national identification or through recognition of the long history of black and brown bodies producing fashionable objects. To advance the global history of fashion, the introduction briefly discusses the work of designers Rawan Maki (Bahrain), Laurence Leenaert (Belgium), and Kim Jones (Great Britain), examining how each upends gender, race, class, or fashion binaries, and analyzes how LVMH and Uniqlo, brands at opposite ends of the contemporary style spectrum, underline the very different ways in which fashion traverses the globe in the twenty-first century. The introduction concludes with the hope that this issue will raise questions about fashion’s articulation of the relation among the local, the national, and the global, as well as about the human experience of interacting with the fashion industry in one national context while living in a globalized world.
Local Ontology and Lived Experience of Fashion toward a Gulf Fashion “Sustainability”
Authors: Maki Rawan 
Published: January 2023

Abstract
What makes fashion “local”? What makes it “sustainable”? Can non-Western fashion locales have the same definitions of sustainability espoused by the global industry? This article reflects on a fashion “sustainability” for Bahrain and the Arab Gulf that goes beyond a focus on product. Specifically, the article explores how fashion space is used in Bahrain by different groups, as well as equity of experience and phenomenology of these spaces in Bahrain. Fashion spaces—such as the mall or souk—are primary areas of public gathering in the Gulf. Based on the results of qualitative interviews and a Delphi study, this article puts forward the example of fashion spaces and tailoring in Bahrain, where an expanded definition of use is found in Gulf fashion practice when compared to the traditional “life cycle” view used in fashion sustainability discourse. These differences in fashion ontology compared to a Western context impact what could be considered true “innovation” in the case of the Arab Gulf. For instance, cocreation through tailoring in the Gulf is culturally prevalent and a default feature of existing material culture, whereas similar notions are classified in a context of “innovation” in Western discourse. Thus it becomes crucial to explore an Arab Gulf ontology of fashion as a precursor to its “sustainability” and honest discussion of its own transformation toward sustainability.
Convoluted Yarns
Authors: Rea Ann 
Published: January 2023

Abstract
Contrary to the claims of advertising, the Aran sweater is a wholly modern phenomenon; because it emerged in the early twentieth century, however, it became a symbol of authentic Irish identity, imbued with qualities that resist commercialization and industrial production and that even provide links to premodern rural culture that the Irish diaspora strips away. While postcolonial postmodernity may render authentic culture unfeasible, contemporary advertising intensifies the mystification and romanticization of the Aran sweater, even with the garment’s increasing machine production.
Έμφυλες διαφοροποιήσεις στην ψυχική υγεία: θεωρητικές προσεγγίσεις, ευρήματα και προοπτικές
Authors: Ζήση Αναστασία 
Published: January 2023

Το παρόν άρθρο στοχεύει σε μια κριτική και σύντομη επισκόπηση των βασικών θεωρητικών προσεγγίσεων για την εξήγηση των έμφυλων διαφοροποιήσεων στην ψυχική υγεία ακολουθώντας τρεις κατευθύνσεις. Η πρώτη κατεύθυνση αντιστοιχεί στην ψυχολογική προσέγγιση που δίνει έμφαση στις έμφυλες ταυτισιακές διαδικασίες και την ψυχική οργάνωση κατά την πρώιμη παιδική ηλικία, το γνωστικό ύφος και τα ατομικά σχέδια δράσης ανά φύλο. H δεύτερη κατεύθυνση αντιστοιχεί στην κοινωνικο-υλιστική προσέγγιση που ενδιαφέρεται για τις έμφυλες δομικές ανισότητες και τον αντίκτυπο τους στην ψυχική υγεία κυρίως των γυναικών, και η τρίτη, ακολουθεί τις μεταδομιστικές θεωρίες για τη λογοθετική, έμφυλη συγκρότηση της ψυχικής εμπειρίας. Παρουσιάζονται οι θεωρητικές παραδοχές και αντιπροσωπευτικά ευρήματα της κάθε προσέγγισης χωριστά, όπως και οι περιορισμοί ως προς την εξηγητική τους ισχύ. Οι ψυχολογικές σπουδές φύλου στην Ελλάδα έχουν χαμηλή ακαδημαϊκή παρουσία παρά τις επίσημες εκθέσεις αλλά και τα κείμενα των φεμινιστικών κινημάτων της βάσης που δείχνουν την επιδείνωση της θέσης των γυναικών στις περισσότερες κοινωνίες, όπου η γενικευμένη ανδρική κυριαρχία διαιωνίζεται. Αυτή η επιδείνωση έχει συνδεθεί με τα προγράμματα λιτότητας και την μαζική υποχώρηση του κράτους πρόνοιας που μετατρέπει τις γυναίκες σε έναν «εφεδρικό στρατό άμισθης κοινωνικής φροντίδας», και με την αναζωπύρωση του δεξιόστροφου αυταρχισμού σε πολλές κυβερνήσεις κρατών που προωθούν αναχρονιστικές νομοθεσίες αλλά και μια νέου τύπου σεξιστική κουλτούρα.
The mother-to-child transmission of HIV-1 and profile of viral reservoirs in pediatric population: A systematic review with meta-analysis of the Cameroonian studies
Authors: Ka’e Aude Christelle , Nka Alex Durand , Yagai Bouba , Domkam Kammogne Irénée , Ngoufack Jagni Semengue Ezechiel , Nanfack Aubin Joseph , Nkenfou Celine , Tommo Tchouaket Michel Carlos , Takou Desire , Sosso Samuel Martin , Fainguem Nadine , Abba Aissatou , Pabo Willy , Kamgaing Nelly , Temgoua Edith , Tchounga Boris , Tchendjou Patrice , Tetang Suzie , Njom Nlend Anne Esther , Ceccherini-Silberstein Francesca , Mercedes Santoro Maria , Fokam Joseph 
Published: January 2023

Background
The mother-to-child transmission of HIV-1 (MTCT) remains on the major route of HIV-transmission among pediatric populations in Africa. Though a prevention of MTCT (PMTCT) high-priority country, data on the MTCT burdens in Cameroon remains fragmented.

Objective
We sought to assess the pooled MTCT rate, its risk-factors, and to characterize viral reservoirs of infected-children in Cameroon.

Methods
All relevant observational cohort and cross-sectional studies conducted in Cameroon were searched from PubMed, African Journals Online, Google scholar, ScienceDirect and academic medical education databases. Heterogeneity and publication bias were respectively assessed by the I2 statistic and the Egger/funnel plot test. Meta-analysis was performed using the random effects model. MTCT rate >5% was considered as “high”. This review was registered in the Prospero database, CRD42021224497.

Results
We included a total of 29 studies and analyzed 46 684 children born from HIV-positive mothers. The overall rate of MTCT was 7.00% (95% CI = 6.07–8.51). According to regions, the highest burden was in Adamaoua-region (17.51% [95% CI:14.21–21.07]) with only one study found. PMTCT option-B+ resulted in about 25% reduction of MTCT (8.97% [95% CI: 8.71–9.24] without option-B+ versus 2.88% [95% CI: 5.03–9.34] with option-B+). Regarding risk-factors, MTCT was significantly associated with the absence of PMTCT-interventions both in children (OR:5.40 [95% CI: 2.58–11.27]) and mothers (OR: 3.59 [95% CI: 2.15–5.99]). Regarding viral reservoirs, a pro-viral DNA mean of 3.34±1.05 log10/mL was observed among 5/57 children and archived HIV drug resistance mutations were identified in pro-viral DNA marker among 21/79 infected-children.

Conclusion
In spite of the dropdown in MTCT following option-B+ implementation, MTCT remains high in Cameroon, with substantial disparities across regions. Thus, in this era of option-B+, achieving MTCT elimination requires interventions in northern-Cameroon. The variation in pro-viral load in infected-children underlines the relevance of characterizing viral reservoirs for possible infection control in tropical settings.
A hyperinflammation clinical risk tool, HI5-NEWS2, stratifies hospitalised COVID-19 patients to associate risk of death and effect of early dexamethasone in an observational cohort
Authors: Ardern-Jones Michael R. , Phan Hang T. T. , Borca Florina , Stammers Matt , Batchelor James , Reading Isabel C. , Fletcher Sophie V. , Smith Trevor , Duncombe Andrew S. 
Published: January 2023

Background
The success of early dexamethasone therapy for hospitalised COVID-19 cases in treatment of Sars-CoV-2 infection may predominantly reflect its anti-inflammatory action against a hyperinflammation (HI) response. It is likely that there is substantial heterogeneity in HI responses in COVID-19.

Methods
Blood CRP, ferritin, neutrophil, lymphocyte and platelet counts were scored to assess HI (HI5) and combined with a validated measure of generalised medical deterioration (NEWS2) before day 2. Our primary outcome was 28 day mortality from early treatment with dexamethasone stratified by HI5-NEWS2 status.

Findings
Of 1265 patients, high risk of HI (high HI5-NEWS2) (n = 367, 29.0%) conferred a strikingly increased mortality (36.0% vs 7.8%; Age adjusted hazard ratio (aHR) 5.9; 95% CI 3.6–9.8, p<0.001) compared to the low risk group (n = 455, 36.0%). An intermediate risk group (n = 443, 35.0%) also showed significantly higher mortality than the low risk group (17.6% vs 7.8%), aHR 2.2, p = 0.005). Early dexamethasone treatment conferred a 50.0% reduction in mortality in the high risk group (36.0% to 18.0%, aHR 0.56, p = 0.007). The intermediate risk group showed a trend to reduction in mortality (17.8% to 10.3%, aHR 0.82, p = 0.46) which was not observed in the low risk group (7.8% to 9.2%, aHR 1.4, p = 0.31).

Interpretation
Higher HI5-NEWS2 scores measured at COVID-19 diagnosis, strongly associate with increased mortality at 28 days. Significant reduction in mortality with early dexamethasone treatment was only observed in the high risk group. Therefore, the HI5-NEWS2 score could be utilised to stratify randomised clinical trials to test whether intensified anti-inflammatory therapy would further benefit high risk patients and whether alternative approaches would benefit low risk groups. Considering its recognised morbidity, we suggest that early dexamethasone should not be routinely prescribed for HI5-NEWS2 low risk individuals with COVID-19 and clinicians should cautiously assess the risk benefit of this intervention in all cases.
No Machos or Pop Stars: When the Leeds Art Experiment Went Punk, Gavin Butt (2022)
Authors: Bestley Russ 
Published: January 2023

Review of: No Machos or Pop Stars: When the Leeds Art Experiment Went Punk, Gavin Butt (2022)
Durham, NC: Duke University Press, 282 pp.,
ISBN 978-1-47801-863-6, p/bk, £20.99
From Arthaus to Bauhaus, 1972–1979, Andrew J. Brooksbank (2021)
Authors: Bestley Russ 
Published: January 2023

Review of: From Arthaus to Bauhaus, 1972–1979, Andrew J. Brooksbank (2021)
Stratford-upon-Avon: Tome & Metre, 284 pp.,
ISBN 978-1-83801-161-1, p/bk, £15.00
perfil das pessoas em situação de rua no brasil e a importância da sua reinserção na sociedade
Authors: Santos Maria Vera dos , Silva Evania Souza e , Souza Luiza Catarina Sobreira de 
Published: January 2023

Existe no Brasil uma média de 24.588 pessoas em situação de rua que estão incluídas em programas sociais, uma população que vive com menos de um dólar por dia e são considerados abaixo da linha da pobreza, não havendo contabilização do real número e características destes indivíduos pelos institutos responsáveis pelo senso populacional. Salienta-se, ainda, que essa população tem os vínculos familiares interrompidos ou fragilizados, sendo frutos de um longo processo de desigualdades e exclusão social. Os moradores de rua são tratados ora com compaixão ora com repressão, e mesmo sendo este assunto debatido há anos, ele não tem destaque na sociedade. Sendo assim, o objetivo desse trabalho foi tratar sobre a necessidade de reinserção dessa população na sociedade. Para tanto, adotou-se como método de abordagem o dedutivo e como procedimento metodológico o levantamento bibliográfico, sendo a pesquisa classificada como exploratória.
Goal-Directed Action Is Initially Impaired in a hAPP-J20 Mouse Model of Alzheimer’s Disease
Authors: Dhungana Amolika , Becchi Serena , Leake Jessica , Morris Gary , Avgan Nesli , Balleine Bernard W. , Vissel Bryce , Bradfield Laura A. 
Published: January 2023

AbstractCognitive-behavioral testing in preclinical models of Alzheimer’s disease has failed to capture deficits in goal-directed action control. Here, we provide the first comprehensive investigation of goal-directed action in a transgenic mouse model of Alzheimer’s disease. Specifically, we tested outcome devaluation performance in male and female human amyloid precursor protein (hAPP)-J20 mice. Mice were first trained to press left and right levers for pellet and sucrose outcomes, respectively (counterbalanced), over 4 d. On test, mice were prefed one of the outcomes to satiety and given a choice between levers. Devaluation performance was intact for 36-week-old wild-types of both sexes, who responded more on the valued relative to the devalued lever (Valued > Devalued). By contrast, devaluation was impaired (Valued = Devalued) for J20 mice of both sexes, and for 52-week-old male mice regardless of genotype. After additional lever press training (i.e., 8-d lever pressing in total), devaluation was intact for all mice, demonstrating that the initial deficits were not a result of a nonspecific impairment in reward processing, depression, or locomotor activity in J20 or aging mice. Follow-up analyses revealed that microglial expression in the dorsal CA1 region of the hippocampus was associated with poorer outcome devaluation performance on initial, but not later tests. Together, these data demonstrate that goal-directed action is initially impaired in J20 mice of both sexes and in aging male mice regardless of genotype, and that this impairment is related to neuroinflammation in the dorsal CA1 hippocampal region.
USP1/UAF1-Stabilized METTL3 Promotes Reactive Astrogliosis and Improves Functional Recovery after Spinal Cord Injury through m6A Modification of YAP1 mRNA
Authors: Ge Xuhui , Ye Wu , Zhu Yufeng , Cui Min , Zhou Jiawen , Xiao Chenyu , Jiang Dongdong , Tang Pengyu , Wang Jiaxing , Wang Zhuanghui , Ji Chengyue , Zhou Xuhui , Cao Xiaojian , Liu Wei , Cai Weihua 
Published: January 2023

RNA N6-methyladenosine (m6A) modification is involved in diverse biological processes. However, its role in spinal cord injury (SCI) is poorly understood. The m6A level increases in injured spinal cord, and METTL3, which is the core subunit of methyltransferase complex, is upregulated in reactive astrocytes and further stabilized by the USP1/UAF1 complex after SCI. The USP1/UAF1 complex specifically binds to and subsequently removes K48-linked ubiquitination of the METTL3 protein to maintain its stability after SCI. Moreover, conditional knockout of astrocytic METTL3 in both sexes of mice significantly suppressed reactive astrogliosis after SCI, thus resulting in widespread infiltration of inflammatory cells, aggravated neuronal loss, hampered axonal regeneration, and impaired functional recovery. Mechanistically, theYAP1transcript was identified as a potential target of METTL3 in astrocytes. METTL3 could selectively methylate the 3′-UTR region of theYAP1transcript, which subsequently maintains its stability in an IGF2BP2-dependent manner.In vivo, YAP1 overexpression by adeno-associated virus injection remarkably contributed to reactive astrogliosis and partly reversed the detrimental effects of METTL3 knockout on functional recovery after SCI. Furthermore, we found that the methyltransferase activity of METTL3 plays an essential role in reactive astrogliosis and motor repair, whereas METTL3 mutant without methyltransferase function failed to promote functional recovery after SCI. Our study reveals the previously unreported role of METTL3-mediated m6A modification in SCI and might provide a potential therapy for SCI.SIGNIFICANCE STATEMENTSpinal cord injury is a devastating trauma of the CNS involving motor and sensory impairments. However, epigenetic modification in spinal cord injury is still unclear. Here, we propose an m6A regulation effect of astrocytic METTL3 following spinal cord injury, and we further characterize its underlying mechanism, which might provide promising strategies for spinal cord injury treatment.
Implementasi Pendekatan Pembelajaran Saintifik pada Pembelajaran PPKn di Kelas X
Authors: Maradila Diah Ayu , Wahono Margi 
Published: January 2023

Curriculum 2013 aims to create productive, creative, innovative, affective Indonesian people by strengthening the integration of attitude, skill and knowledge. This curriculum points out scientific approach as the implemented approach in education, especially Civic Education learning. The approach is believed as the best way to develop attitude, skill and knowledge of students.Â The objective of this study is to find out the implementations, obstacles, and methods to resolve scientific approachâ€™s problem in Civic Education learning Class X in SMA Negeri 1 Kradenan. This study uses qualitative methods. The techniques of collecting data are: observation, interview, and documentation. The validity of study is examined by triangulation technique. The techniques of analyzing data are: reduction, presentation and conclusion. This study shows: (1) the implementations scientific approach in Civic Education learning Class X in SMA Negeri 1 Kradenan which are started from planning, implementation of 6M activities (Observing, Questioning, Experimenting, Associating, Communicating, and Creating ), and scoring. This learning method involves introduction, main activity, and conclusion. (2) the obstacles of implementing scientific approach in Civic Education learning are experienced by Civic Educationâ€™Â teachers and students. There are some obstacles in every steps of the scientific approach, they are: observing, questioning, collecting information, reasoning, and communicating. (3) teachers implement some methods to overcome obstacles of implementing scientific approach in Civic Education learning. The methods which are implemented in every step are: observing, questioning, collecting information, reasoning, and communicating.