bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Short-Term Efficacy of Bifidobacterium Quadruple Viable Tablet in Patients With Diarrhea-Predominant Irritable Bowel Syndrome: Potentially Mediated by Metabolism Rather Than Diversity Regulation
Authors: Bai Tao , Xu Zhiyue , Xia Peijun , Feng Yichao , Liu Bing , Liu Hongling , Chen Yunwang , Yan Guangjun , Lv Bin , Yan Zaihong , Dai Ning , Long Yanqin , Wei Wei , Shi Zhihong , Li Xiaoqing , Fang Xiucai , Gao Huibin , Qi Lingzhi , Hou Xiaohua 
Published: January 2023

INTRODUCTION:
The therapeutic effect of probiotics for irritable bowel syndrome (IBS) was controversial. This study aims to evaluate the short-term efficacy of Bifidobacterium quadruple viable tablet in patients with diarrhea-predominant IBS and explore factors associated with response to probiotics.

METHODS:
A randomized, double-blind, placebo-controlled, multicenter trial was performed in 15 hospitals. A total of 290 patients who fulfilled the eligibility criteria were assigned to the probiotics or placebo group randomly with a ratio of 1:1 for a 4-week treatment and a 2-week follow-up. The primary outcome was the response rate. It was regarded as the proportion of patients with composite responses of improvement in both abdominal pain and diarrhea simultaneously.

RESULTS:
After 4-week continuous administration, the response rates of the probiotics and the placebo were 67.59% and 36.55%, respectively (P < 0.001). In the probiotics, those with higher abdominal pain scores (2.674 [1.139–6.279]) were more likely to respond, but responders in placebo had lower Hamilton Depression Scale score (0.162 [0.060–0.439]), lower Hamilton Anxiety Scale score (0.335 [0.148–0.755]), and higher degree of bloating (2.718 [1.217–6.074]). Although the diversity of the microbiota was not significantly changed by probiotics, the abundance of bacteria producing short-chain fatty acids (SCFAs), including Butyricimonas (P = 0.048), Pseudobutyrivibrio (P = 0.005), Barnesiella (P = 0.020), and Sutterella (P = 0.020), and the concentration of SCFAs including butyric acid (P = 0.010), valeric acid (P = 0.019), and caproic acid (P = 0.046) in feces increased.

DISCUSSION:
A Bifidobacterium quadruple viable tablet had a significant short-term efficacy for the treatment of diarrhea-predominant IBS and was more effective in patients with higher abdominal pain scores. This kind of probiotics could improve the abundance of several bacteria producing SCFAs and the concentration of fecal SCFAs compared with placebos.
A Prospective Study of Preemptive Tenofovir Disoproxil Fumarate Therapy in HBsAg-Positive Patients With Diffuse Large B-Cell Lymphoma Receiving Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone
Authors: Kim Do Young , Kim Yu Ri , Suh Cheolwon , Yoon Dok Hyun , Yang Deok-Hwan , Park Yong , Eom Hyeon Seok , Lee Jeong-Ok , Kwak Jae-Yong , Kang Hye Jin , Hyun Shin Young , Jo Jae-Cheol , Chang Myung Hee , Yoo Kwai Han , Lim Sung-Nam , Shin Ho-Jin , Kim Won Seog , Kim In-Ho , Kim Min Kyung , Kim Hyo Jung , Lee Won-Sik , Mun Yeung-Chul , Kim Jin Seok 
Published: February 2023

INTRODUCTION:
This prospective study aimed to investigate the efficacy and safety of preemptive antiviral therapy with tenofovir disoproxil fumarate (TDF) for HBsAg-positive patients with newly diagnosed diffuse large B-cell lymphoma receiving rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy.

METHODS:
We enrolled 73 patients from 20 institutions. The primary end point was the absolute risk of hepatitis B virus (HBV)-related hepatitis during preemptive TDF therapy and for 24 weeks after withdrawal from TDF. Hepatitis was defined as a more than 3-fold increase in serum alanine aminotransferase from baseline or an alanine aminotransferase level of ≥100 U/L. HBV-related hepatitis was defined as hepatitis with an increase in serum HBV-DNA to >10 times that of the pre-exacerbation baseline or an absolute increase of ≥20,000 IU/mL compared with the baseline.

RESULTS:
No patient developed HBV reactivation or HBV-related hepatitis during preemptive antiviral therapy (until 48 weeks after completion of R-CHOP chemotherapy) with TDF. All adverse events were grade 1 or 2. HBV reactivation was reported in 17 (23.3%) patients. All HBV reactivation was developed at a median of 90 days after withdrawal from TDF (range, 37–214 days). Six (8.2%) patients developed HBV-related hepatitis at a median of 88 days after withdrawal from TDF (range, 37–183 days).

DISCUSSION:
Preemptive TDF therapy in HBsAg-positive patients with diffuse large B-cell lymphoma receiving R-CHOP chemotherapy was safe and effective for preventing HBV-related hepatitis. However, a long-term maintenance strategy of preemptive TDF therapy should be recommended because of the relatively high rate of HBV-related hepatitis after withdrawal from TDF (ClinicalTrials.gov ID: NCT02354846).
Pathogen-Specific Alterations in the Gut Microbiota Predict Outcomes in Flare of Inflammatory Bowel Disease Complicated by Gastrointestinal Infection
Authors: Axelrad Jordan E. , Chen Ze , Devlin Joseph , Ruggles Kelly V. , Cadwell Ken 
Published: February 2023

INTRODUCTION:
Enteric infection with Clostridioides difficile, Escherichia coli subtypes, and norovirus is commonly detected in flares of inflammatory bowel disease (IBD). We associated the gut microbiome during flare complicated by a gastrointestinal pathogen with outcomes of IBD.

METHODS:
We performed a cross-sectional study of 260 patients (92 IBD and 168 non-IBD) with a gastrointestinal polymerase chain reaction panel positive for C. difficile, E. coli, or norovirus, or negative during an episode of diarrhea from 2018 to 2020, and 25 healthy controls. Clinical variables, IBD status, and 2-year outcomes were collected. Using 16S rRNA sequencing, we measured the effect size of the gut microbiome on IBD characteristics and outcomes.

RESULTS:
There were major differences in the gut microbiome between patients with and without a pathogen and IBD. In IBD, a higher proportion of patients without a pathogen required hospitalization and IBD therapies at flare and within the 2 years after flare, driven by a milder disease course in flares complicated by an E. coli subtype or norovirus. Examining the contribution of clinical covariates, the presence of IBD, and C-reactive protein, C. difficile had a greater relative influence on the gut microbiome compared with the presence of an E. coli subtype or norovirus. In patients with C. difficile or no pathogen, lower microbiome diversity at flare was associated with adverse IBD outcomes over 2 years.

DISCUSSION:
Distinctive pathogen-specific gut microbiomes were associated with subsequent IBD outcomes. These findings may have direct implications for the management of IBD flares complicated by enteric pathogens.
Validity and Diagnostic Performance of Computing Fractional Flow Reserve From 2-Dimensional Coronary Angiography Images
Authors: Mohammadi Vahid , Ghasemi Massoud , Rahmani Reza , Mehrpooya Maryam , Babakhani Hamidreza , Shafiee Akbar , Sadeghian Mohammad 
Published: January 2023

Background
Measurement of fractional flow reserve (FFR) is the gold standard for determining the physiologic significance of coronary artery stenosis, but newer software programs can calculate the FFR from 2-dimensional angiography images.

Methods
A retrospective analysis was conducted using the records of patients with intermediate coronary stenoses who had undergone adenosine FFR (aFFR). To calculate the computed FFR, a software program used simulated coronary blood flow using computational geometry constructed using at least 2 patient-specific angiographic images. Two cardiologists reviewed the angiograms and determined the computational FFR independently. Intraobserver variability was measured using κ analysis and the intraclass correlation coefficient. The correlation coefficient and Bland-Altman plots were used to assess the agreement between the calculated FFR and the aFFR.

Results
A total of 146 patients were included, with 95 men and 51 women, with a mean (SD) age of 61.1 (9.5) y. The mean (SD) aFFR was 0.847 (0.072), and 41 patients (27.0%) had an aFFR of 0.80 or less. There was a strong intraobserver correlation between the computational FFRs (r = 0.808; P < .001; κ = 0.806; P < .001). There was also a strong correlation between aFFR and computational FFR (r = 0.820; P < .001) and good agreement on the Bland-Altman plot. The computational FFR had a high sensitivity (95.1%) and specificity (90.1%) for detecting an aFFR of 0.80 or less.

Conclusion
A novel software program provides a feasible method of calculating FFR from coronary angiography images without resorting to pharmacologically induced hyperemia.
Titik Lemah Industri Keuangan Fintech di Indonesia: Kajian Perbandingan Hukum
Authors: Sudirman Lu , Disemadi Hari Sutra 
Published: February 2023

Kemajuan teknologi mendorong industri keuangan digital terus mengalami perkembangan yang semakin pesat dan salah satunya adalah financial fechnology (fintech). Indonesia belum memiliki regulasi yang spesifik, menjadikan Indonesia masih lemah secara pondasi hukum dalam mewujudkan suatu kemajuan dalam industri keuangan. Penelitian ini bertujuan untuk memahami dan menganalisa kondisi pengaturan fintech khususnya di Indonesia dan Singapura. Metode penelitian yang digunakan adalah hukum normatif dengan menggunakan data yang diperoleh melalui studi kepustakaan. Hasil penelitian ini menunjukan perkembangan industri fintech Indonesia yang tergolong maju, dapat terus dikembangkan dengan menelaah perkembangan industri fintech yang ada di Singapura. Hukum fintech Indonesia dan Singapura masih bertumpu pada beberapa aturan yang dikeluarkan Otoritas Jasa Keuangan (OJK) di Indonesia dan Monetary Authority of Singapore (MAS) di Singapura. Inilah yang masih menjadi titik lemah kedua bangsa ini. Peran hukum yang masih terkesan lemah menjadikan suatu celah besar yang harus segera diperbaiki dalam arus perkembangan industri fintech. Industri Fintech yang melibatkan masyarakat secara luas dan mengandung nominal uang yang sangat banyak, perlunya suatu hadirnyahukum yang dapat menjamin perlindungan kepentingan para stakeholders.
Cost-Reducing Technologies and Labor Supply in a Krugman-type Model where Consumption is Time-Constrained: Some New Results
Authors: Pant Manoj , Huria Sugandha 
Published: January 2023

Abstract
This study demonstrates why traditional “cost-saving” technical progress fails in an economy where consumption is time-constrained. In such a case, introducing “time-saving” technical progress establishes a new consumption-production equilibrium characterized by higher per-capita consumption and real income, lower prices, and, a higher scale of production for surviving producers. Nonetheless, since there is a limit to how much time can be saved by technological advances, the model also suggests an alternative solution in the form of a rising labor force (say via immigration) to close the production-consumption gap. This solution generates an unambiguous increase in welfare, vis-à-vis cost-reducing or time-saving technical progress.
MD-based study on the deformation process of engineered Ni–Al core–shell nanowires: Toward an understanding underlying deformation mechanisms
Authors: Mohammed Bassam A. , Batbooti Raed S. 
Published: February 2023

Abstract
Nowadays, core/shell structures due to very high thermal and electrical conductivity are taken into account in the manufacture of many industrial sensors and catalysis. Ni–Al core/shell structures are known as one of the most practical materials due to their high chemical stabilities at elevated temperatures. Since the evaluation of the mechanical properties of the industrial core/shell catalysts is crucial, identification of the mechanism responsible for their plastic deformation has been a challenging issue. Accordingly, in this study, the mechanical properties and plastic deformation process of Ni–Al core/shell structures were investigated using the molecular dynamics method. The results showed that due to the high-stress concentration in the Ni/Al interface, the crystalline defects including dislocations and stacking faults nucleate from this region. It was also observed that with increasing temperature, yield strength and elastic modulus of the samples decrease. On the other hand, increasing the temperature promotes the heat-activated mechanisms, which reduces the density of dislocations and stacking faults in the material. Consequently, the obstacles in the slip path of the dislocations as well as dislocation locks are reduced, weakening the mechanical properties of the samples.
Studie zum Entwicklungsprozess des positiven Images von Chinesen in der deutsch-chinesischen Wirtschaftskommunikation: Reziproke Perspektive
Authors: Wang Enuo 
Published: February 2023

Zusammenfassung
Das Image von Chinesen in der Wirtschaftskommunikation verändert sich mit der Globalisierung. Basierend auf einer Inhaltsanalyse wird das positive Image von Chinesen in der deutsch-chinesischen Wirtschaftskommunikation aus reziproker Perspektive mithilfe des Begriffes der Imageforschung rekonstruiert und untersucht. In diesem Beitrag werden das Interview als Datenerhebungsinstrument und die Inhaltsanalyse als Analysemethode verwendet. Die Interviewfragen wurden mit einem Fokus auf positive Bilder von Chinesen entworfen. Basierend auf den Interviewfragen wurden Tiefeninterviews mit 16 deutschen und 20 chinesischen Mitarbeitern, die im Kontext der chinesisch-deutschen Wirtschaftskommunikation tätig sind, unter einer interaktiven Perspektive durchgeführt. Als wirkungsvolle Ergänzung zu den Tiefeninterviews wurden Betriebsexkursionen und Datenerhebungen durchgeführt. Durch systematische Gegenüberstellung dieser von beiden Seiten entwickelten drei Bildertypen lässt sich der Grad an kognitiver Kongruenz oder Inkongruenz bestimmen. Auf den vier Ebenen der geschäftlichen Aktivitäten wie Kommunikation, Beziehung, Arbeit und Leistung wird das positive Bild von Chinesen in der Wirtschaftskommunikation beschrieben und analysiert. Auf dieser Basis wird die kulturelle Relevanz der chinesisch-deutschen Wirtschaftskommunikation zusammengefasst. Die Forschungsergebnisse zeigen, dass chinesische Kulturfaktoren wie Höflichkeit, Menschenfreundlichkeit und Flexibilität einen Einfluss auf das Bild von Chinesen haben. Die Ergebnisse zeigen auch, dass der Entwicklungsprozess des positiven Images von Chinesen in der chinesisch-deutschen Wirtschaftskommunikation Eigenschaften wie Relativität, Mehrdimensionalität und Synergie widerspiegelt.
Exploring the Experiences of Male Intercollegiate Soccer Coaches who are People of Color
Authors: Parris Patrice , Workman Jamie , Archibald James , Asola Eugene 
Published: February 2023

AbstractThe purpose of this study was to explore and discuss the lived experiences and stories of people of color male intercollegiate soccer coaches, and to make meaning of their experiences to better understand why there are a lack of people of color male coaches in the NCAA soccer community. Critical race theory served as the theoretical framework. Through the use of narrative inquiry, the researchers interviewed people of color male soccer coaches in the NCAA. The researchers analyzed, categorized, and coded into themes using procedures for conducting and analyzing narrative research. Several themes emerged from interviews with six people of color college male soccer coaches. In this article, the authors discuss two major themes, relationships and race, and provides implications for intercollegiate coaches and administrators as well as directions for future research.
Aptamer-based detection of serotonin based on the rapid in situ synthesis of colorimetric gold nanoparticles
Authors: Ip Im-Fong , Wang Yi-Shan , Chang Chia-Chen 
Published: February 2023

Abstract
Serotonin, a neurotransmitter that affects brain function, is associated with cancer progression, thus making it a potential biomarker. Despite the increasing efforts and ideas for gold nanoparticle (AuNP)-based colorimetric detection over the years, preparing AuNPs and sensing targets are separate processes, and this incurs more time to operate and produces excess waste. Herein, we report a simple, sensitive, and rapid colorimetric detection method for serotonin based on the in situ formation of AuNP. When only the aptamer is present, it can prevent chloride-induced aggregation of AuNPs because it easily binds to the freshly synthesized AuNPs through its exposed bases to increase the positive charge of the AuNP surfaces. When a complex of serotonin and its aptamer is formed, this complex disturbs the adsorption between aptamers and AuNPs, resulting in reduced stability of AuNPs and easy aggregation of nanoparticles. Therefore, serotonin was measured by color change, consistent with the change in peak intensity in the UV-vis absorption spectrum. The sensor demonstrated good sensitivity with a detection limit of 1 ng/mL (5.7 nM) for serotonin, which is comparable to or better than that of other aptamer-based colorimetric detection methods, further exhibiting the requisite selectivity against possible interferents. These results serve as a basis for developing other biosensors using aptamer-mediated in situ growth of AuNPs.
Adoption of IoT-based healthcare devices: An empirical study of end consumers in an emerging economy
Authors: Dutta Abhisek , Kovid Raj K. , Thatha Mounika , Gupta Jatin 
Published: February 2023

Abstract
The Internet of things (IoT) is a technology with varied applications in numerous fields. One such field is healthcare, which has a dire need of using this technology to help millions benefit from the attention and availability of healthcare professionals. This study identifies important factors that influence the adoption of IoT-based healthcare devices among end users and suggest a predictive model of adoption. The model is based on the UTAUT2 with newer variables identified from the literature. The sample (n = 253) was collected from four major cities in India, and partial least squares-structural equational model was used to assess the measurement and the structural model. The factors such as ubiquitous, social influence, perceived health risk, and relative advantage had a significant influence on attitude (ATT), which influences behavioral intention (BI) toward IoT-based healthcare devices. Facilitating condition (FC) and price value did not show any significant influence on ATT toward the technology, but FC had a direct influence on BI. The study helps in advancing IS research by adding new variables to the existing knowledge and proposing a model based on UTAUT2. Furthermore, it also brings important practical implications for practitioners.
Microbial production of lactic acid using organic wastes as low-cost substrates
Authors: Chauhan Sushmita , Mitra Shreya , Yadav Mukesh , Kumar Amit 
Published: January 2023

Abstract
Lactic acid is a natural organic acid with diverse of applications in food, pharmaceutical, cosmetics, and chemical industry. Recently, the demand of lactic acid has been grown due to its utilization for polylactic acid production. Microbial production of lactic acid production is preferable due to optical purity of product, utilization of low cost substrates, and low energy requirement. Lignocellulosic biomass and other organic wastes are considered potential raw materials for cost-effective production of lactic acid. The raw materials are either hydrolyzed by enzymes or dilute acids to release the reducing sugars that are fermented in to lactic acid. This review has been focussed on microbial production of lactic acid using different organic wastes as low cost substrate.
Are VEGF and SCUBE1 gene expressions increased in diabetic retinopathy?
Authors: Ayan Durmuş , Zor Kürşad Ramazan , Özmen Esma , Biçer Gamze Yıldırım , Önder Çağatay Emir , Sarı İsmail 
Published: February 2023

Abstract

Objectives
In the current study, we synergistically evaluated vascular endothelial growth factor (VEGF) gene expression levels and signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) gene expression levels in diabetic patients without retinopathy, non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR).

Methods
94 blood samples from 26 healthy controls, 29 non-DR, 22 NPDR, and 17 PDR patients were collected in sterile EDTA tubes. Total RNA was obtained from these samples without waiting and then converted to cDNA. The expression levels of the VEGF and SCUBE1 genes were determined by quantitative real-time polymerase chain reaction (qPCR).

Results
SCUBE1 gene expression levels were 2.15 (p=0.015), 1.75 (p=0.799), 2.37 (p=0.037) times higher, and VEGF gene expression levels were 1.71 (p=0.023), 1.75 (p=0.012), 1.85 (p=0.031) times higher in the non-DR, NPDR, and PDR groups compared to the control group, respectively. VEGF gene expression levels were significantly higher in participants with HbA1c levels ≥5.7% compared to those with <5.7. SCUBE1 and VEGF gene expression levels were significantly higher in participants with fasting plasma glucose (FPG) levels ≥126 mg/dL than those with <126 mg/dL.

Conclusions
As a result, SCUBE1 gene expression levels are higher than VEGF gene expression levels, especially in the PDR group. Therefore, SCUBE1 may contribute to the pathology of DR just like VEGF by generating angiogenesis. However, we believe there is a need for experimental animal model studies with DR examining SCUBE1 gene expression levels in tissue samples.
Analyzing pH-dependent structural characteristics and optical transmittance of titanium dioxide
Authors: Anwar Nadia , Iqbal Muhammad Aamir , Ahmed Muqarrab , Anwar Bushra , Abbas Iqra , Iqbal Syeda Tehreem , Anwar Fouzia , Mushahid Nosheen , Capangpangan Rey Y. , Alguno Arnold C. 
Published: February 2023

AbstractThe use of titanium dioxide (also known as titania) in solar cells, biomaterials, and photocatalytic processes has generated an ever-increasing amount of interest. Titania is widely used in a variety of applications because it is nanocrystalline, chemically stable, has a high refractive index, is mechanically hard, and transmits visible light well. In this work, titania nanoparticles were formed via sol–gel synthesis, wherein the effect of varying pH values such as 3, 5, 7, 9, and 11 has been investigated on the synthesized nanoparticles by studying their structural characteristics and analyzing their optical transmittance. Structural analysis of the synthesized TiO2shows formation of the brookite phase at all pH values under as-synthesized conditions. Moreover, structural parameters including crystallite size, dislocation density, and unit cell volume were also calculated. Cell volume was calculated at various pH levels and measured between 255.7 and 257.2 Å3. Optical analysis shows a transmission increase with a pH increase, and maximum transmission has been observed above 80% for a pH value of 11.