bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new tumorgraft panel to accelerate precision medicine in prostate cancer
Authors: Béraud Claire , Bidan Nadege , Lassalle Myriam , Lang Hervé , Lindner Véronique , Krucker Clémentine , Masliah-Planchon Julien , Potiron Eric , Lluel Philippe , Massfelder Thierry , Allory Yves , Misseri Yolande 
Published: May 2023

BackgroundDespite the significant advances in the management of advanced prostate cancer (PCa), metastatic PCa is currently considered incurable. For further investigations in precision treatment, the development of preclinical models representing the complex prostate tumor heterogeneity are mandatory. Accordingly, we aimed to establish a resource of patient-derived xenograft (PDX) models that exemplify each phase of this multistage disease for accurate and rapid evaluation of candidate therapies.MethodsFresh tumor samples along with normal corresponding tissues were obtained directly from patients at surgery. To ensure that the established models reproduce the main features of patient’s tumor, both PDX tumors at multiple passages and patient’s primary tumors, were processed for histological characteristics. STR profile analyses were also performed to confirm patient identity. Finally, the responses of the PDX models to androgen deprivation, PARP inhibitors and chemotherapy were also evaluated.ResultsIn this study, we described the development and characterization of 5 new PDX models of PCa. Within this collection, hormone-naïve, androgen-sensitive and castration-resistant (CRPC) primary tumors as well as prostate carcinoma with neuroendocrine differentiation (CRPC-NE) were represented. Interestingly, the comprehensive genomic characterization of the models identified recurrent cancer driver alterations in androgen signaling, DNA repair and PI3K, among others. Results were supported by expression patterns highlighting new potential targets among gene drivers and the metabolic pathway. In addition, in vivo results showed heterogeneity of response to androgen deprivation and chemotherapy, like the responses of patients to these treatments. Importantly, the neuroendocrine model has been shown to be responsive to PARP inhibitor.ConclusionWe have developed a biobank of 5 PDX models from hormone-naïve, androgen-sensitive to CRPC primary tumors and CRPC-NE. Increased copy-number alterations and accumulation of mutations within cancer driver genes as well as the metabolism shift are consistent with the increased resistance mechanisms to treatment. The pharmacological characterization suggested that the CRPC-NE could benefit from the PARP inhibitor treatment. Given the difficulties in developing such models, this relevant panel of PDX models of PCa will provide the scientific community with an additional resource for the further development of PDAC research.
A mainstreaming oncogenomics model: improving the identification of Lynch syndrome
Authors: O’Shea Rosie , Crook Ashley , Jacobs Chris , Kentwell Maira , Gleeson Margaret , Tucker Katherine M. , Hampel Heather , Rahm Alanna Kulchak , Taylor Natalie , Lewis Sarah , Rankin Nicole M. 
Published: May 2023

Introduction“Mainstreaming” is a proposed strategy to integrate genomic testing into oncology. The aim of this paper is to develop a mainstreaming oncogenomics model by identifying health system interventions and implementation strategies for mainstreaming Lynch syndrome genomic testing.MethodsA rigorous theoretical approach inclusive of conducting a systematic review and qualitative and quantitative studies was undertaken using the Consolidated Framework for Implementation Research. Theory-informed implementation data were mapped to the Genomic Medicine Integrative Research framework to generate potential strategies.ResultsThe systematic review identified a lack of theory-guided health system interventions and evaluation for Lynch syndrome and other mainstreaming programs. The qualitative study phase included 22 participants from 12 health organizations. The quantitative Lynch syndrome survey included 198 responses: 26% and 66% from genetic and oncology health professionals, respectively. Studies identified the relative advantage and clinical utility of mainstreaming to improve genetic test access and to streamline care, and adaptation of current processes was recognized for results delivery and follow-up. Barriers identified included funding, infrastructure and resources, and the need for process and role delineation. The interventions to overcome barriers were as follows: embedded mainstream genetic counselors, electronic medical record genetic test ordering, results tracking, and mainstreaming education resources. Implementation evidence was connected through the Genomic Medicine Integrative Research framework resulting in a mainstreaming oncogenomics model.DiscussionThe proposed mainstreaming oncogenomics model acts as a complex intervention. It features an adaptable suite of implementation strategies to inform Lynch syndrome and other hereditary cancer service delivery. Implementation and evaluation of the model are required in future research.
Case report: Post-COVID new-onset neurocognitive decline with bilateral mesial-temporal hypometabolism in two previously healthy sisters
Authors: Cocciolillo Fabrizio , Chieffo Daniela Pia Rosaria , Giordano Alessandro , Arcangeli Valentina , Lazzareschi Ilaria , Morello Rosa , Zampino Giuseppe , Valentini Piero , Buonsenso Danilo 
Published: May 2023

BackgroundLong coronavirus disease (COVID) is increasingly recognized in adults and children; however, it is still poorly characterized from a clinical and diagnostic perspective, particularly in the younger populations.Case presentationWe described the story of two sisters—with high social and academic performance before their severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection—who reported severe neurocognitive problems, initially classified as psychologic pandemic distress and eventually found to have significant brain hypometabolism.ConclusionsWe provided a detailed clinical presentation of neurocognitive symptoms in two sisters with long COVID associated with brain hypometabolism documented in both sisters. We believe that the evidence of objective findings in these children further supports the hypothesis that organic events cause persisting symptoms in a cohort of children after SARS-CoV-2 infection. Such findings highlight the importance of discovering diagnostics and therapeutics.
The nature and structure of maternal parenting practices and infant behaviors in U.S. national and international samples
Authors: Bornstein Marc H. , Putnick Diane L. , Esposito Gianluca , Pearson Rebecca M. 
Published: May 2023

MethodsTwenty maternal parenting practices and 15 behaviors of their 5½-month-old infants in a U.S. national sample (N = 360) and 9 international samples (N = 653) were microcoded from videorecords of naturalistic interactions at home and aggregated into domains. Altogether, the samples were recruited from Argentina, Belgium, Brazil, France, Israel, Italy, Japan, Kenya, as well as the United States.Background and RationaleA previous test of three competing models of the nature and structure of the maternal parenting practices supported a hybrid 2 factor/6 domain model as superior to a 1-factor dimensional model and a multi-factor style model: Maternal parenting practices are structured into nurture, physical, social, didactic, material, and language domains undergirded by dyadic and extradyadic factors. Infant behaviors were organized into physical, social, exploration, nondistress vocalization, and distress communication domains. The current study sought to examine links connecting these previously identified maternal domains and factors with infant behavior domains using structural equation models.ResultsMothers' dyadic factor is associated with infant social behaviors with mother; and mothers' extradyadic factor and encouragement of infant physical development are associated with infant exploration of their immediate physical environment and physical development. Infant distress communication (and less nondistress vocalization) is associated with more maternal nurturing.DiscussionMothers' parenting practices in the middle of the first year of infant life are commonly structured and adapted to specific needs and developmental tasks of infants. Evaluations of mother-infant interactions with national and international samples permit a wide yet judicious analysis of common vs. specific models of mother-infant relationships.
Concentration of milk oxylipins after heat and homogenization treatments
Authors: Thum Caroline , Cirelli Amanda , Otoki Yurika , Ozturk Gulustan , Taha Ameer Y. , McNabb Warren C. , Roy Nicole C. , Leite Nobrega de Moura Bell Juliana Maria 
Published: May 2023

Heat treatment and homogenization of milk are common processing steps intended to reduce microbial load for safe human consumption, and to avoid creaming, respectively. Although the effects of combined pasteurization and homogenization on free fatty acids (FFA) and lipid oxidation markers such as hydroperoxides, and thiobarbituric acid reactive species (TBARS) have been well characterized, their effects on primary oxidized fatty acids known as oxylipins have not yet been determined. This study aimed to determine the effects of two heat treatments: milk pasteurization [high-temperature short time, 72°C for 15 s (HTST)] and sterilization [ultra-high temperature, 135°C for 3 s (UHT)] with or without homogenization (10, 17 or 24 MPa) on FFA (%), primary (hydroperoxides and oxylipins) and secondary oxidation compounds (TBARS). Heat treatments alone significantly reduced most oxylipins compared with raw milk, but did not alter % FFA, hydroperoxide, and TBARS levels. The combination of UHT and homogenization at 24 MPa increased % FFA, hydroperoxide value, and some oxylipins, compared to raw milk and other treatments. Overall, the combination of heat treatment and homogenization significantly increased oxylipin formation compared with heat treatment alone.
The Health Economic Assessment Tool (HEAT) for walking and cycling - experiences from 10 years of application of a health impact assessment tool in policy and practice
Authors: Kahlmeier Sonja , Cavill Nick , Thondoo Meelan , Rutter Harry , de Sa Thiago Herick , Racioppi Francesca , Gotschi Thomas 
Published: May 2023

IntroductionIn recent years, walking and cycling have moved into the focus as promising approaches to achieve public health, sustainable transport, climate goals and better urban resilience. However, they are only realistic transport and activity options for a large proportion of the population when they are safe, inclusive and convenient. One way to increase their recognition in transport policy is the inclusion of health impacts of walking and cycling into transport economic appraisals.MethodsThe Health Economic Assessment Tool (HEAT) for walking and cycling calculates: if x people walk or cycle a distance of y on most days, what is the economic value of impacts on premature mortality, taking into account effects of physical activity, air pollution and road fatalities, as well as effects on carbon emissions. Different data sources were collated to examine how the HEAT in more than 10 years of existence, and to identify lessons learned and challenges.ResultsSince its launch in 2009, the HEAT has gained wide recognition as a user friendly, yet robust, evidence-based tool usable by academics, policymakers, and practitioners. Originally designed for use in Europe, it has since been expanded for global use.DiscussionChallenges for a wider uptake of health-impact assessment (HIA) tools including active transport such as HEAT are the promotion and dissemination to local practitioners and policy makers also outside European and English-speaking regions and in low- and middle-income contexts, further increasing usability, and more generally the advancement of systematic data collection and impact quantification related to walking and cycling.
Three-dimensional simulation/printing-assisted surgery for symptomatic metastatic epidural spinal cord compression of posterior column: efficacy assessment based on 2-year follow-up
Authors: Sun Zhicheng , Jia Runze , Wang Xiyang , Pang Xiaoyang 
Published: May 2023

BackgroundSurgical intervention is necessary for resolving the symptoms of the spinal cord and nerve compression caused by symptomatic metastatic epidural spinal cord compression. However, surgeons are constantly seeking ways to improve surgical efficiency and safety. This study aims to evaluate the efficacy of 3D simulation/printing-assisted surgery for symptomatic metastatic epidural spinal cord compression of the posterior column.MethodsWe retrospectively analyzed the clinical data of patients who underwent surgical treatment for symptomatic metastatic epidural spinal cord compression of the posterior column in our hospital from January 2015 to January 2020. The simulated group underwent a 3D digital simulation of the lesion area using imaging data before surgery. Twelve patients in the simulated group also received 3D printing, while the direct surgery group did not receive any 3D simulation or printing. All patients were followed up for at least 2 years. We collected clinical data, including operation time, intraoperative blood loss, pedicle screw adjustment rate, intraoperative fluoroscopy times, the incidence of dural injury and cerebrospinal fluid leakage, VAS score, postoperative neurological function improvement, and tumor recurrence. Statistical analysis was performed using SPSS23.0, and P &lt; 0.05 was considered statistically significant.ResultsA total of 46 patients were included in this study, with 20 in the simulated group and 26 in the non-simulated group. The simulated group had better operation time, intraoperative blood loss, screw adjustment rate, fluoroscopy times, and incidence of dural injury/cerebrospinal fluid leakage compared to the non-simulated group. The VAS scores of the two groups improved significantly after the operation and at the last follow-up compared to before the operation. However, there was no statistically significant difference between the two groups. There was also no statistically significant difference in neurological function improvement between the two groups. In the simulated group, 25% of patients relapsed, while in the non-simulated group, 34.61% of patients relapsed. However, there was no statistical difference between the two groups.ConclusionPreoperative 3D simulation/printing-assisted surgery is a practical and feasible approach for treating symptomatic metastatic epidural spinal cord compression of the posterior column.
FUTURE SPECIALIST IN PHYSICAL EDUCATION AND SPORTS TRAININGIN USING MOTION GAMES IN PROFESSIONAL ACTIVITIES
Authors: Khlibkevych S. 
Published: May 2023

The article defines the specific features of a future specialist in physical education and sports training in using motion games in professional activities. Based on the analysis of educational standards and programs of specialist training, a comparative analysis of the methodological features of the teaching courses «Motion Games in Sports» and «Theory and Methodology of Teaching Motion Games and Entertainment» has been carried out in accordance with the requirements of the competency approach; the main integrated tasks of the training courses have been defined, the requirements for the knowledge, abilities, skills, culture of motor activity of future specialists in the field of physical culture and sports have been formulated. The phasing of the future physical culture and sports specialists’ pedagogical actions while implementing game methods is substantiated.
Conclusions have been made and practical recommendations have been provided based on the results of a comparative analysis of the educational programme: in general, the course «Motion Games in Sports» and «Theory and Teaching Methods of Motion Games and Entertainment» meet the requirements of the competence approach and the future specialists’ professional activities; teaching, structuring of material and distribution of forms and methods of teaching are carried out in accordance with the principles of consistency and systematicity; it is recommended to strengthen the program content of the course «Theory and Teaching Methods of Motion Games and Entertainment» with educational material about the role of motion games in the development of a person’s physical qualities and the differentiation of games by sports; teaching the discipline «Motion Games in Sports» for future coaches requires strengthening of age differentiation and substantiation of age aspects of the motion games usage; for the course «Motion Games in Sports» and «Theory and Teaching Methods of Motion Games and Entertainment» it is necessary to strengthen the research and project components of future specialists’ education.
Revenue Management Capability and Host Professionalization Degree
Authors: Sainaghi Ruggero 
Published: May 2023

This study explores how a revenue management capability can be created by Airbnb hosts and the role played by the professionalization degree, defined as the number of listings managed by a host. The theoretical lenses used by this study is the resource-based. Based on previous studies on revenue management in the field of hospitality, a wide list of routines, skills, know-how and coordination mechanisms are considered to explain how the revenue management capability can be created by a host. In particular, the revenue management process can be segmented into four major components: i) identifying the required information to set the revenue management strategy, ii) taking strategic and then tactical pricing and revenue management decisions, iii) managing the communication and interaction with the guests, and iv) the availability of a software dedicated to revenue management.
The study is based on qualitative data collected through interviews in the Milan destination. In line with previous studies, three different groups of hosts where identified: i) single hosts (also called group one), ii) hosts managing 3-5 listings (group two), iii) hosts managing more than 10 listings (group 3). The interviews were recorded, transcribed and coded using the software NVIVO. Results reports strong differences between the three groups of hosts and especially between single and big hosts (those managing ten or more listings). The goals itself are different: while single hosts prefer to select guest and maximize price, big hosts, supporting higher fixed costs, are strongly focused on revenue. All the four blocks are therefore managed in a different way. Small hosts are widely involved in the operating processes (check-in, cleaning, guest interaction) and in many cases the short-term rental is only an additional activity (the main work in another). Therefore, the time dedicated to data collection and revenue management strategy is limited. The opposite is for big hosts that are usually organized as a company with employees specialized per function and with a strong focus on revenue maximization. The paper is supportive for the emerging idea of professionalization degree. The study traces theoretical as well as practical conclusions. The main study limitations are listed.
The Pilgrim Consumer Behaviour along the Way of St. James
Authors: Monteiro Rafael , Silva Susana , Azevedo Daniel 
Published: May 2023

The purpose of this study is contributing to increase the knowledge about Pilgrim’s behaviour during their journey. It focuses mainly on food consumption expenses and habits. The study aims to describe the behavior of pilgrims along the Santiago route.
A cross-sectional quantitative study was performed to achieve our objectives. 225 pilgrims fulfilled a survey to characterise their profile and their consumption pattern during the pilgrimage.
Our results showed that most of the pilgrims describe themselves as tourist or mystical and transcendental. The pilgrimage lasts 13 days performing 23,6 kilometers for 6,5 hours per day. Regarding differences in the amount of money spent according to the pilgrim profile or the pilgrimage we only observe significant differences for the tourist profile intending to spend more money per day. In the same way, pilgrims performing less than 6 hours of walking per day intend to spend more money.
In conclusion, it seems that the Saint James Way seems to attract more people to the local community increasing their availability to spend money locally
Metode Proyek (Gardening) untuk Mengembangkan Kecerdasan Naturalis Anak di TK Alam Mutiara Umat
Authors: Sari Yuyun Indah , Suyadi  
Published: May 2023

Childhood is a period of play, playing activities will certainly provide real experiences and explore their natural intelligence, but in reality these activities have been replaced with the lecture method, in which children become bored. Therefore, it is necessary to have a project method to develop children's naturalist intelligence. This study aims to develop children's naturalist intelligence. Data collection techniques using observation and interviews. The data analysis technique uses conclusion drawing. Checking the validity of the findings using triangulation and peer examination. The results showed that with the project method, the naturalist intelligence of children could develop well.

ABSTRAK
Masa anak adalah masa bermain, dalam kegiatan bermain tentunya akan memberikan pengalaman nyata dan mengeksplor kecerdasan nauralisnya, namun pada kenyataannya kegiatan tersebut telah terganti menjadi metode ceramah, yang mana anak menjadi bosan. Oleh sebab itu diperlukan adanya metode proyek untuk mengembangkan kecerdasan naturalis anak. Penelitian ini bertujuan untuk mengembangkan kcerdasan naturalis anak. Teknik pengumpulan data menggunakan observasi dan wawancara. Teknik analisis data menggunakan penarikan kesimpulan. Pengecekan keabsahan temuan menggunakan triangulasi dan pemeriksaan teman sejawat. Hasil penelitian menunjukkan bahwa dengan adanya metode proyek maka kecerdasan naturalis anak dapat berkembang dengan baik.
PERILAKU ANAK AUTIS : PERKEMBANGAN DAN PENANGAN
Authors: Veryawan Armanila Sri Inda Lestari , Sri Inda Lestari  , Indah  , Veryawan  
Published: May 2023

R.A Baiturrofiqoh there is one hyperactive autistic child, therefore the researchers tried to examine this which aims to find out how the development of autistic children, stimulation of handling autistic children is clarified by supporting factors and inhibiting wear and tear in early childhood. The results of this study are the development of autistic children has begun to calm down when learning with teacher handling stimulation, namely trying to provide learning that is easily accepted by autistic children as well as inhibiting factors for children with learning difficulties and supporting factors for children or women. This study uses a descriptive qualitative research method in which all data were obtained through observation, interviews and documentation in accordance with the problem to be studied. Therefore, researchers hope to help teachers in teaching autistic children.Â Â