bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated transcriptomic and metabolomic profiles reveal the protective mechanism of modified Danggui Buxue decoction on radiation-induced leukopenia in mice
Authors: Chen Wei , Xin Jiayun , Wei Xintong , Ding Qianqian , Shen Yunheng , Xu Xike , Wei Yanping , Lv Yanhui , Wang Jie , Li Zhanhong , Zhang Weidong , Zu Xianpeng 
Published: August 2023

Leukopenia caused by radiation hinders the continuous treatment of cancers. Danggui Buxue Decoction (DBD) has been widely used in clinical owing to low toxicity and definite therapeutic effects to increase leukocytes. Meanwhile, icaritin (ICT) has also been proved to have the effect of boosting peripheral blood cells proliferation. However, there is no study to prove the efficacy of MDBD (Modified Danggui Buxue Decoction), a derivative herbal formula composed of DBD and ICT, in the treatment of radiation-induced leukopenia. In this study, we performed a model of 3.5 Gy whole-body radiation to induce leukopenia in mice. The results of pharmacodynamic studies demonstrated that MDBD could significantly increase the white blood cells in peripheral blood by improving the activity of bone marrow nuclear cells, reducing bone marrow damage, modulating spleen index, and regulating hematopoietic factors to alleviate leukopenia. We also analyzed the integrated results of metabolomics and transcriptomics and found that MDBD could relieve leukopenia and alleviate bone marrow damage by targeting steroid biosynthesis and IL-17 signaling pathway, in which the key genes are Jun, Cxcl2 and Egr1. Therefore, our study provides a basis for the effectiveness and compatibility in the combination of traditional Chinese medicine formula and small molecule drugs.
Resistance strategies and attitude certainty in persuasion: bolstering vs. counterarguing
Authors: Blankenship Kevin L. , Machacek Marielle G. , Standefer Jack 
Published: August 2023

IntroductionAlthough resistance to persuasion has been of interest in psychology, relatively little research has examined how different resistance strategies can affect the strength-related features of attitudes. The current research presents a metacognitive account of two resistance strategies and their effect on attitude certainty and intentions. Specifically, we examine how the strategies of counterarguing and bolstering can differentially affect attitude certainty and intentions to act on the attitude under attack.MethodsIn two experiments, we implemented a 2(Perceived Thought Type: bolster vs. counterargue) x 2(Perceived Argument Quality: weak vs. strong) between-participants design. Participants read weak or strong arguments about a counterattitudinal topic. After reporting their thoughts in response to the message topic, participants received bogus feedback regarding the nature of their thoughts (i.e., bolstering or counterarguing). Following the feedback, participants reported their attitudes and attitude certainty.ResultsIn Experiment 1 (N =241), participants’ thoughts perceived as counterarguments elicited attitude certainty that was more sensitive to the quality of the attacking information than when thoughts were perceived as bolstering one’s opinion. Experiment 2 (N  = 287) replicated the effect with a different topic and demonstrated a similar pattern on intentions to act on the attacked attitude.DiscussionThe research demonstrates that two relatively thoughtful strategies, bolstering and counterarguing, can play an important role in attitude certainty and intentions following a persuasion attempt.
Promoting culturally informed and sensitive practice in day-care centers—a contribution to the professionalization of day-care teachers
Authors: Buchner Ursula Gisela , Eberl Constanze Maria Luise , Hess Markus 
Published: August 2023

BackgroundBased on the growing number of families and young children with a refugee background in Germany, day-care teachers face enormous challenges regarding culturally informed practice. The project “Gemeinsam stark durch den Start” (Stronger together by starting together) addresses these challenges on various levels. At the level of day-care teachers, training in culturally informed and sensitive education is combined with reflection sessions about their own attitudes and prevailing intercultural norms, thus contributing to the professionalization of day-care teachers.AimThis paper focuses on mechanisms of action that contributed to the effectiveness of the training from two perspectives: the day-care teachers’ perspective and the trainers’ perspective.MethodsStaff members of 11 German day-care centers underwent graded online training sessions (team and in-depths trainings) addressing intercultural topics. All participants were presented with a questionnaire for their training evaluation before and after the training sessions. Also, participants of the in-depths trainings participated in semi-structured interviews on the training. Furthermore, qualitative interviews were conducted with all trainers (N = 4) of the workshops.ResultsDay-care teachers evaluated the online training positively, especially the improvement of professionalization and the implementation of training elements. Results reveal that (work-related) reflexive sessions as well as sessions dealing with the implementation of exercise tools into daily practice were rated as fundamental parts in the training. Teachers from high-risk day-care centers estimated the trainings’ effectiveness lower than those working in low-risk day-care centers. Qualitative data shows that the day-care teachers are in need of (theoretical) knowledge about all training elements and hands-on advice for dealing with specific situations. Especially day-care teachers within a high-risk environment, who already report having an elevated level of intercultural knowledge and skills, may need a higher dose training while low-risk day-care teachers may profit more from a low threshold training.ConclusionThe introduced training sessions focusing on intercultural sensitivity and competence present an important contribution to the professionalization of day-care teachers in working with children from different cultural backgrounds. Trainings should focus on reflexive elements as well as exercises in perspective taking and provide hands on materials for daily work.
Professional identification in the beginning of a teacher’s career: a longitudinal study on identity formation and the basic psychological need for autonomy in VET teacher training
Authors: Weiß Julia Katharina , Bottling Matthias , Kärner Tobias 
Published: August 2023

IntroductionThis study examines the extent to which VET trainee teachers’ identification with their profession is related to their basic psychological need for autonomy and whether this is reflected in their intention to stay in the field. Trainee’s subjective experience of their professional identity interacts with different conditions of the training environment, whereby we focus on perceived autonomy support and autonomy thwarting behavior of seminar teachers.MethodsOn the basis of a longitudinal design with a total of 79 trainee teachers in Germany and four survey time points during teacher training, corresponding developmental processes were traced over a total period of 1 year. Cross-lagged panel analyses allow us to draw conclusions about the extent to which professional identification of trainees interacts with autonomy-support or autonomy-thwarting conditions originating from seminar teachers and to what extent the aforementioned factors in turn affect intention to stay.ResultsCross-lagged panel analyses show that professional identification after 6 months in teacher training significantly predicts the intention to stay in the teaching profession half a year later. Significant cross paths each describe positive effects between professional identification and autonomy support and negative effects between professional identification and autonomy thwarting.DiscussionParticularly against the background of the shortage of teachers in Germany and other countries, the promotion of professional identification processes in the sense of a teacher identity can be assessed as crucial. In this respect, an autonomy-supporting environment, e.g., created by seminar teachers, can already contribute to that during teacher training.
The effect of long-haul COVID-19 toward domains of the health-related quality of life among recovered hospitalized patients
Authors: Trihandini Indang , Muhtar Manendra , Karunia Sakti Dea Allan , Erlianti Chintya Putri 
Published: August 2023

BackgroundPeople with long-haul COVID-19 could experience various health problems, from mild to severe. This research aimed to identify the effect of long-haul COVID-19, specifically on the Quality-of-Life domains experienced by COVID-19 patients who have been discharged.MethodsData collection was done online, using data from DKI Jakarta hospitalized patients confirmed with and recovered from SARS-CoV-2 infections. We selected patients who have a minimum of 28 days after being hospitalized for COVID-19 positive. The Logistic regression technique was used to analyze the data. The questionnaire used in this research contained questions regarding long-haul COVID-19 symptoms and domains of Quality of Life, which WHOQOL-BREF measured. Before collecting data, we tested the questionnaire with 30 recovered patients hospitalized outside DKI Jakarta.Results172 recovered inpatients who filled out the questionnaire correctly and were aged 18 years and above were randomly selected. Almost one-third (30.2%) of the recovered inpatients had long-haul COVID-19, with 23.8% experiencing one long-haul symptom and 6.4% experiencing more than one symptom. This research also showed that the long-haul effects of COVID-19 affected almost all domains of Quality of Life except the environmental one. Age, gender, and marital status were covariates for the association between long-haul COVID-19 and The Quality of Life.ConclusionContinuing health services after the patient is discharged from the hospital is an important program for COVID-19 survivors because it can prevent a decline in the Quality of Life among patients due to the long-haul COVID-19.
Does the first generic exclusivity system provide an economic incentive for early generic entrance under the patent linkage system?
Authors: Son Kyung-Bok 
Published: August 2023

IntroductionA period of exclusivity for the first generics, as part of the patent linkage system, was established in South Korea to provide an economic incentive for early generic entry. This study describes the dynamics of generic penetration and assesses the first mover market share advantages under the patent linkage system.MethodsPairs of originators and their corresponding generics granted the first generic exclusivity from 2015 to 2020 were identified. We categorized generics into first movers and latecomers, described the penetration curves of generics, and estimated the saturated market share of generics, first movers, and latecomers. Volume-based monthly prescriptions were used to describe the generics’ penetration curves. A logistic growth model was adopted to estimate the saturated market shares of generics.ResultsWe identified 28 pairs of originators and generics, presented penetration curves, and estimated generics market shares. The saturated market share of generics was 30%, and the time to saturation was approximately 33 months. The shapes of penetration varied by nationality, route, and number of generics. The existence of latecomers was associated with the decreased penetration speed over time and decreased market share of generics. However, the first mover market share advantages or latecomers’ disadvantages were consistently observed.ConclusionThe generic uptake in South Korea is delayed, limited, and context-dependent. However, first generics’ market share advantage suggests that a period of exclusivity, as part of the patent linkage system, could provide an economic incentive for early generic entrance.
Barriers and strategies for recruiting participants who identify as racial minorities in musculoskeletal health research: a scoping review
Authors: Le Denise , Almaw Rachel D. , Rinaldi Daniel , Ivanochko Natasha K. , Harris Sheereen , Benjamin Ashley , Maly Monica R. 
Published: August 2023

ObjectiveVisible minorities are disproportionately affected by musculoskeletal disorders (MSD) and other diseases; yet are largely underrepresented in health research. The purpose of this scoping review was to identify barriers and strategies associated with increasing recruitment of visible minorities in MSD research.MethodsElectronic databases (MEDLINE, EMBASE, CINAHL, and PsycInfo) were searched. Search strategies used terms related to the concepts of ‘race/ethnicity’, ‘participation’, ‘research’ and ‘musculoskeletal’. All research designs were included. Two reviewers independently screened titles and abstracts, completed full-text reviews, and extracted data. Papers that did not focus on musculoskeletal research, include racial minorities, or focus on participation in research were excluded. Study characteristics (study location, design and methods; sample characteristics (size, age, sex and race); MSD of interest) as well as barriers and strategies to increasing participation of visible minorities in MSD research were extracted from each article and summarized in a table format.ResultsOf the 4,282 articles identified, 28 met inclusion criteria and were included. The majority were conducted in the United States (27 articles). Of the included studies, the groups of visible minorities represented were Black (25 articles), Hispanic (14 articles), Asian (6 articles), Indigenous (3 articles), Middle Eastern (1 article), and Multiracial (1 article). The most commonly cited barriers to research participation were mistrust, logistical barriers (e.g., transportation, inaccessible study location, financial constraints), and lack of awareness or understanding of research. Strategies for increasing diversity were ensuring benefit of participants, recruiting through sites serving the community of interest, and addressing logistical barriers.ConclusionUnderstanding the importance of diversity in MSD research, collaborating with communities of visible minorities, and addressing logistical barriers may be effective in reducing barriers to the participation of visible minorities in health research. This review presents strategies to aid researchers in increasing inclusion in MSD-related research.
Perceptions of antimicrobial stewardship: identifying drivers and barriers across various professions in Canada utilizing a one health approach
Authors: McCubbin Kayley D. , de Jong Ellen , Smid Anne-Marieke C. , Ida Jennifer A. , Bodaneze Julia , Anholt R. Michele , Larose Samantha , Otto Simon J. G. , Barkema Herman W. 
Published: August 2023

IntroductionAs antimicrobial resistance (AMR) represents a substantial threat to the efficacy of available antimicrobial options, it is important to understand how to implement effective and practical mitigation efforts, including antimicrobial stewardship (AMS), across human, animal, and environmental sectors.MethodsA mixed-methods questionnaire was distributed virtually to attendees of the virtual One Health Antimicrobial Stewardship Conference (March 10–12, 2021) and their professional networks. Respondents (n = 81) were largely from the veterinary (75%) or human (19%) health sectors. Qualitative data were analyzed in NVivo using template analysis whereas quantitative data were analyzed in STATA using Kruskall-Wallis tests. The questionnaire asked respondents about their perceptions of AMS, as well as the perceived barriers and drivers of AMS efforts.ResultsPerceptions of what AMS meant to the respondents personally and their profession as a whole were grouped into 3 main themes: 1) AMS strategies or considerations in antimicrobial prescribing and use; 2) responsibility to maintain health and preserve antimicrobial effectiveness; and 3) reducing antimicrobial use (AMU) as a goal of AMS efforts. Identified AMS barriers had 3 main themes: 1) lack of various prescribing and AMU support mechanisms; 2) shift in prescriber attitudes to drive change; and 3) stronger economic considerations to support shifting prescribing practices. Drivers of AMS had the following themes: 1) leadership to guide change; 2) education to support optimizing AMU; and 3) research to identify best practices and opportunities for action. Across all questions, 2 cross-cutting themes emerged: 1) a One Health understanding of AMS; and 2) blame placed on others for a lack of AMS success.ConclusionOverall, sector-specific, but particularly cross-sectoral AMS drivers and barriers were identified, highlighting the importance of a One Health approach in AMR research and mitigation.
ANALISIS GRAVITY LOCATION MODEL DALAM PENENTUAN LOKASI GUDANG PADA SUPPLY CHAIN MANAGEMENT
Authors: Susanto Rani 
Published: August 2023

Kegiatan distribusi barang merupakan salah satu kegiatan dalam perancangan jaringan supply chain management. Kegiatan ini bertujuan agar produk yang dikirimkan tepat waktu dengan ongkos yang minimal. Dalam kegiatan pendistribusian, penempatan sumber pasokan dengan lokasi fasilitas memiliki peranan penting untuk memastikan barang bisa terkirim dengan baik kepada pelanggan. Jarak antara sumber pasokan dengan lokasi fasilitas yang relatif jauh menyebabkan ongkos transportasi menjadi semakin membengkak. PT. X merupakan perusahaan yang menerapkan jaringan supply chain pada perusahaannya dalam pemenuhan kebutuhan barang setiap kantor cabangnya. Lokasi cabang yang saling berjauhan dan kebutuhan barang yang berbeda-beda menyebabkan total ongkos (cost) semakin membengkak. Maka dari itu perusahaan membutuhkan rekomendasi lokasi fasilitas gudang penyimpanan barang untuk kebutuhan distribusi dengan lokasi yang paling optimal dan total ongkos yang minimal. Metode Gravity Location Model digunakan untuk menentukan lokasi yang akan menjadi penghubung antara sumber pasokan dengan lokasi fasilitas terkait. Model ini mempertimbangkan asumsi jika ongkos akan naik sesuai dengan volume yang dipindahkan dan penentuan koordinat x,y sebagai penentu lokasi. Hasil penelitian ini menyatakan bahwa titik koordinat yang paling optimal yang akan menjadi lokasi fasilitas gudang baru total ongkos (cost) sebesar Rp888.611. Dengan hasil tersebut, perusahaan mendapatkan rekomendasi lokasi fasilitas gudang yang paling optimal untuk memenuhi kebutuhan barang disetiap kantor cabangnya.
Kata Kunci: supply chain management, distribusi, Gravity Location Model
perusahaan ini yaitu pada titik (0,5;1,9) dengan
Rancang Bangun Sistem Informasi Point of Sale (POS) Berbasis Web (Studi Kasus Toko Andorio)
Authors: Mulyana Agus , Rusmawan Uus 
Published: August 2023

Proses manajemen penjualan yang saat ini berjalan di Toko Andorio masih menggunakan metode tradisional atau konvensional. Metode seperti ini kurang efisien dan efektif karena melibatkan penggunaan banyak buku nota dan tulisan manual. Pembuatan laporan juga memakan waktu karena harus menyalin data dari nota penjualan. Tujuan dari penelitian ini adalah mengembangkan sistem informasi Point Of Sale (POS) sebagai sarana untuk meningkatkan efisiensi dan efektivitas dalam proses penjualan dan pembuatan laporan di Toko Andorio. Dalam penelitian ini, metode perancangan aplikasi yang diterapkan adalah metode Waterfall, Waterfall merupakan salah satu metode Rekayasa Perangkat Lunak. Proses perancangan aplikasi ini dilakukan secara berurutan, dimulai dengan melakukan analisis kebutuhan, merancang sistem, melakukan implementasi dan pengujian, menerapkan program, dan terakhir adalah pemeliharaan. Bahasa pemrograman yang digunakan adalah PHP, dengan database MySQL. Hasil dari penelitian ini adalah Aplikasi sistem informasi Point Of Sale berbasis web yang dapat digunakan untuk memudahkan kegiatan oprasional Toko Andorio mulai dari proses transaksi seperti pembelian dan penjualan, serta memudahkan dalam rekapitulasi laporan seperti laporan pembelian, penjualan dan laporan stok.
Kata Kunci: MYSQL, PHP, Point of sale, Waterfall
Tratamento de maxila atrófica com implante personalizado: relato de caso
Authors: Da Maia Renan Prado Reis , Nascimento Ramon dos Santos , Ibanez Rafaella Brandão , Marins Luci Santos , Rivas Marcos Vidal , Cova Júlio César Pereira 
Published: August 2023

Atualmente, um dos maiores desafios para a implantodontia é reestabelecer e reconstruir as funções fisiológicas, estéticas e fonéticas em maxilas atróficas. Quando o nível ósseo do paciente não permite a instalação dos implantes convencionais, o tratamento de reabilitação pode ser realizado através dos procedimentos cirúrgicos reabilitadores, utilizando a tecnologia customizada, fabricada a base de titânio, a partir de análise computadorizada de toda a anatomia bucomaxilofacial do paciente. Neste trabalho é relatar um caso de uma paciente com perda óssea severa em região maxilar, sendo feita a reconstrução utilizando a precisão da Prótese Customizada da Maxila para Reabilitação Protética implantossuportada.
Síndrome de Burnout em profissionais de saúde da atenção primária no município de Guanambi – BA
Authors: Durães Arianne Thandara de Sousa , Fernandes Uilma Magalhães , Moreira Charles Neris , Teixeira Maria Luísa Santos , Nunes Luiz Carlos Pimenta , Souza Vitória Estela Duarte Trindade , Silva Raíssa Baleeiro Alves , Paca Mikaelly Martins 
Published: August 2023

A Síndrome de Burnout é caracterizada por três dimensões: exaustão emocional, despersonalização e realização pessoal. Este estudo buscou analisar os preditores e fatores associados à Síndrome de Burnout nos profissionais da Atenção Primária à Saúde no município de Guanambi, localizado no sudoeste baiano, distante 796 Km da capital do estado. A pesquisa foi realizada com 112 profissionais da atenção primária em 12 Unidades Básicas de Saúde, como instrumento de coleta de dados foi utilizado um questionário sociodemográfico, o Self Report Questionnaire e o Maslach Burnout Inventory. A análise dos dados foi realizada por meio do software IBM® SPSS® Statistics versão 24.0. Foram calculadas as frequências simples, relativas e aplicadas o intervalo de confiança para 95%, também foi utilizado o teste qui-quadrado de Pearson. Obtendo-se que a frequência da Exaustão Emocional é 52,0%, a Despersonalização 43,0% e a baixa Realização Pessoal incide em 66,0% dos profissionais. A prevalência da síndrome segundo os critérios de Grunfeld et al (2000), é 38,0% e de acordo com Ramirez et al (1995), é de 8,0%. Dentre os fatores associados à síndrome, destaca-se o sexo feminino, ser jovem, solteiro, trabalhar mais de 44 horas semanais, sem apresentar diferenças significativas entre as profissões. A maioria dos profissionais (59%) apresentam algum Transtorno Mental Comum de acordo com o Self Report Questionnaire. Esses achados sugerem uma maior vulnerabilidade do profissional da atenção primária à Síndrome de Burnout, sendo fundamental a implementação de ações voltadas para minimizar o esgotamento profissional e subsidiar mais apoio psicoemocional nesse ambiente.