bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic profiling of patients with different idiopathic inflammatory myopathy subtypes reveals potential biomarkers in plasma
Authors: Zhao Qianqian , Hu Qiu , Meng Shuhui , Zhang Qinguo , Wang Tingting , Liu Cuilian , Liu Dongzhou , Jiang Zhenyou , Hong Xiaoping 
Published: April 2023

AbstractIdiopathic inflammatory myopathy (IIM) are heterogeneous autoimmune diseases that primarily affect the proximal muscles. IIM subtypes include dermatomyositis (DM), polymyositis (PM), and anti-synthetase syndrome (ASS). Metabolic disturbances may cause irreversible structural damage to muscle fibers in patients with IIM. However, the metabolite profile of patients with different IIM subtypes remains elusive. To investigate metabolic alterations and identify patients with different IIM subtypes, we comprehensively profiled plasma metabolomics of 46 DM, 13 PM, 12 ASS patients, and 30 healthy controls (HCs) using UHPLC-Q Exactive HF mass spectrometer. Multiple statistical analyses and random forest were used to discover differential metabolites and potential biomarkers. We found that tryptophan metabolism, phenylalanine and tyrosine metabolism, fatty acid biosynthesis, beta-oxidation of very long chain fatty acids, alpha-linolenic acid and linoleic acid metabolism, steroidogenesis, bile acid biosynthesis, purine metabolism, and caffeine metabolism are all enriched in the DM, PM, and ASS groups. We also found that different subtypes of IIM have their unique metabolic pathways. We constructed three models (five metabolites) to identify DM, PM, ASS from HC in the discovery and validation sets. Five to seven metabolites can distinguish DM from PM, DM from ASS, and PM from ASS. A panel of seven metabolites can identify anti-melanoma differentiation-associated gene 5 positive (MDA5 +) DM with high accuracy in the discovery and validation sets. Our results provide potential biomarkers for diagnosing different subtypes of IIM and a better understanding of the underlying mechanisms of IIM.
Beyond farming women: queering gender, work and family farms
Authors: Pfammatter Prisca , Jongerden Joost 
Published: April 2023

AbstractThe issue of gender and agriculture has been on the research agendas of civil society organisations, governments, and academia since the 1970s. Starting from the role of women in agriculture, research has mainly focused on the gendered division of work and the normative constitution of the farm as masculine. Although the gendered division of work has been questioned, the idea of binary gender has mostly been taken as a given. This explorative research shifts the attention from the production of (traditional) gender roles to the making and unmaking of binary gender. An ethnographic study of four farms in Switzerland is drawn on to explore queer farming practices and investigate how queer farmers navigate gender normativity and what this tells us about gender in agriculture more broadly. After considering the mechanisms through which queer farmers are discouraged from farming as a livelihood on the basis of their sex, gender or sexuality, this article argues that queer farmers de- and re-construct gender and farming identities differently, which has research and policy implications for a more diverse and resilient rurality.
Dynamic stochastic modeling for adaptive sampling of environmental variables using an AUV
Authors: Berget Gunhild Elisabeth , Eidsvik Jo , Alver Morten Omholt , Johansen Tor Arne 
Published: April 2023

AbstractDischarge of mine tailings significantly impacts the ecological status of the sea. Methods to efficiently monitor the extent of dispersion is essential to protect sensitive areas. By combining underwater robotic sampling with ocean models, we can choose informative sampling sites and adaptively change the robot’s path based on in situ measurements to optimally map the tailings distribution near a seafill. This paper creates a stochastic spatio-temporal proxy model of dispersal dynamics using training data from complex numerical models. The proxy model consists of a spatio-temporal Gaussian process model based on an advection–diffusion stochastic partial differential equation. Informative sampling sites are chosen based on predictions from the proxy model using an objective function favoring areas with high uncertainty and high expected tailings concentrations. A simulation study and data from real-life experiments are presented.
Elabela, a Novel Peptide, Exerts Neuroprotective Effects Against Ischemic Stroke Through the APJ/miR-124-3p/CTDSP1/AKT Pathway
Authors: Zhang Kang-long , Li Shuang-mei , Hou Jing-yu , Hong Ying-hui , Chen Xu-xiang , Zhou Chang-qing , Wu Hao , Zheng Guang-hui , Zeng Chao-tao , Wu Hai-dong , Fu Jia-ying , Wang Tong 
Published: April 2023

AbstractElabela (ELA), which is the second endogenous peptide ligand of the apelin receptor (APJ) to be discovered, has been widely studied for potential use as a therapeutic peptide. However, its role in ischemic stroke (IS), which is a leading cause of disability and death worldwide and has limited therapeutic options, is uncertain. The aim of the present study was to investigate the beneficial effects of ELA on neuron survival after ischemia and the underlying molecular mechanisms. Primary cortical neurons were isolated from the cerebral cortex of pregnant C57BL/6J mice. Flow cytometry and immunofluorescence showed that ELA inhibited oxygen–glucose deprivation (OGD) -induced apoptosis and axonal damage in vitro. Additionally, analysis of the Gene Expression Omnibus database revealed that the expression of microRNA-124-3p (miR-124-3p) was decreased in blood samples from patients with IS, while the expression of C-terminal domain small phosphatase 1 (CTDSP1) was increased. These results indicated that miR-124-3p and CTDSP1 were related to ischemic stroke, and there might be a negative regulatory relationship between them. Then, we found that ELA significantly elevated miR-124-3p expression, suppressed CTDSP1 expression, and increased p-AKT expression by binding to the APJ receptor under OGD in vitro. A dual-luciferase reporter assay confirmed that CTDSP1 was a direct target of miR-124-3p. Furthermore, adenovirus-mediated overexpression of CTDSP1 exacerbated neuronal apoptosis and axonal damage and suppressed AKT phosphorylation, while treatment with ELA or miR-124-3p mimics reversed these effects. In conclusion, these results indicated that ELA could alleviate neuronal apoptosis and axonal damage by upregulating miR-124-3p and activating the CTDSP1/AKT signaling pathway. This study, for the first time, verified the protective effect of ELA against neuronal injury after ischemia and revealed the underlying mechanisms. We demonstrated the potential for the use of ELA as a therapeutic agent in the treatment of ischemic stroke.
Graphical Abstract
Transdiagnostic Cognitive Behavioral Group Interventions: A Systematic Review
Authors: Joaquim Stephanie Bittencourt , Simões de Almeida Raquel , Marques António J. 
Published: April 2023

Abstract
Background
Transdiagnostic cognitive behavioral therapy (tCBT) has presented itself as an intervention proposal that aims to integrate the common processes of human functioning with the therapeutic strategies of conventional cognitive-behavioral therapy, considered the gold standard for treating numerous disorders.

Objective
As far as we know, this review is the first to specifically evaluate transdiagnostic cognitive-behavioral interventions in groups. This review aimed to systematically examine the evidence regarding the efficacy of cognitive-behavioral transdiagnostic interventions in groups for the adult population compared to the general interventions or no intervention (control/waiting list).

Method
The report of the systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. PsycINFO, PubMed, and Web of Science databases were searched, obtaining a total of 1,058 records. After applying the inclusion and exclusion criteria, 32 articles, published between 2005 and 2022, were selected. Eligible studies were submitted to the assessment of the potential risk of bias through Cochrane's tool for risk assessment of bias (RoB 2).

Results
The results suggest that transdiagnostic treatments are superior to waiting list conditions and the common treatments, and are at least as effective as active control interventions and specific cognitive-behavioral treatments for diagnosis.
On the origin, characteristics, and usefulness of instrumental and relational understanding
Authors: Herheim Rune 
Published: April 2023

AbstractIn this
paper, the aim is to make a theoretical contribution by focusing on the origin, characteristics, and potential values of the concepts of instrumental and relational understanding. Five characteristics are identified to make it easier to operationalise the concepts and use them as an analytical framework. There is also a focus on how the concepts are closely related to two rationales for learning, the instrumental and the social rationale. The potential values of the concepts and their rationales are shown by using them to suggest a revision of the van Hiele framework and to analyse three empirical examples concerning young students’ understanding of triangles and a cylinder.
Carbon fluxes related to land use and land cover change in Baden-Württemberg
Authors: Ulrich Veit , Schultz Michael , Lautenbach Sven , Zipf Alexander 
Published: April 2023

AbstractSpatially explicit information on carbon fluxes related to land use and land cover change (LULCC) is of value for the implementation of local climate change mitigation strategies. However, estimates of these carbon fluxes are often aggregated to larger areas. We estimated committed gross carbon fluxes related to LULCC in Baden-Württemberg, Germany, using different emission factors. In doing so, we compared four different data sources regarding their suitability for estimating the fluxes: (a) a land cover dataset derived from OpenStreetMap (OSMlanduse); (b) OSMlanduse with removal of sliver polygons (OSMlanduse cleaned), (c) OSMlanduse enhanced with a remote sensing time series analysis (OSMlanduse+); (d) the LULCC product of Landschaftsveränderungsdienst (LaVerDi) from the German Federal Agency of Cartography and Geodesy. We produced a high range of carbon flux estimates, mostly caused by differences in the area of the LULCC detected by the different change methods. Except for the OSMlanduse change method, all LULCC methods achieved results that are comparable to other gross emission estimates. The carbon flux estimates of the most plausible change methods, OSMlanduse cleaned and OSMlanduse+, were 291,710 Mg C yr-1 and 93,591 Mg C yr-1, respectively. Uncertainties were mainly caused by incomplete spatial coverage of OSMlanduse, false positive LULCC due to changes and corrections made in OpenStreetMap during the study period, and a high number of sliver polygons in the OSMlanduse changes. Overall, the results showed that OSM can be successfully used to estimate LULCC carbon fluxes if data preprocessing is performed with the suggested methods.
Health risk assessment of methyl mercury from fish consumption in a sample of adult Qatari residents
Authors: Al-Sulaiti Maetha M. , Al-Ghouti Mohammad A. , Ramadan Gouda A. , Soubra Lama 
Published: April 2023

Abstract
Fish constitutes an essential source of high-quality protein and is, at the same time, the source of exposure to many hazardous contaminants, namely mercury and methyl mercury (MeHg). This study aims at assessing the risk that MeHg poses to the health of adult Qatari residents through fish consumption. Data on fish consumption were collected using a self-administered online survey composed of three sections that collected information about the fish-eating patterns of the participants. The fish species that were reported to be consumed by ≥ 3% of the respondents were sampled and analyzed for their total mercury (T-Hg) content levels. MeHg concentrations were derived from T-Hg content levels using a scenario-based approach. Disaggregated fish consumption and contamination data were combined using the deterministic approach to estimate MeHg intakes. The average, 75th, and 95th percentiles of the MeHg intake estimates were determined and compared to the tolerable weekly intake (TWI) set by the European Food Safety Agency (EFSA) (1.3 μg·kg−1·w−1). All fish samples contained T-Hg at levels ˂ 0.3–0.5 µg/g with a mean value of 0.077 µg/g. The study population had an average fish consumption of 736.0 g/week. The average estimated weekly intakes of MeHg exceeded TWI for some fish consumers including females of childbearing age and those following a high-protein diet. Our study highlights the need to establish regulatory guidelines and dietary advice based on risk/benefit ratio.
Marine food consumption by adult Atlantic salmon and energetic impacts of increased ocean temperatures caused by climate change
Authors: Strøm John Fredrik , Ugedal Ola , Rikardsen Audun Håvard , Thorstad Eva Bonsak 
Published: April 2023

AbstractAtlantic salmon Salmo salar are experiencing widespread population declines, and reductions in growth and survival in the marine environment are contributing factors. Our aims were to estimate marine food consumption of adult salmon and to determine how energetics would be directly affected by the increased ocean temperatures associated with climate change. We tagged previous spawners on outward migration (body size 76–119 cm) with archival tags and used a bioenergetic model to combine in situ temperature recordings with individual data on body growth. Average energy consumption was estimated to be 331–813 kJ per day, which is equivalent to 5–11 prey fish with an average body mass of ca. 15 g. Energy content of prey was the most important factor determining food consumption required to maintain growth. Conversely, the increases in ocean temperatures expected with climate change were predicted to have limited physiological effects on energy budgets and limited impact on the food consumption needed to maintain growth. We conclude that climatic warming will impact Atlantic salmon primarily through changes in prey availability and ecosystem structure rather than the direct effects of temperature on physiological performance.
The effectiveness of vaccination, testing, and lockdown strategies against COVID-19
Authors: Fritz Marlon , Gries Thomas , Redlin Margarete 
Published: April 2023

AbstractThe ability of various policy activities to reduce the reproduction rate of the COVID-19 disease is widely discussed. Using a stringency index that comprises a variety of lockdown levels, such as school and workplace closures, we analyze the effectiveness of government restrictions. At the same time, we investigate the capacity of a range of lockdown measures to lower the reproduction rate by considering vaccination rates and testing strategies. By including all three components in an SIR (Susceptible, Infected, Recovery) model, we show that a general and comprehensive test strategy is instrumental in reducing the spread of COVID-19. The empirical study demonstrates that testing and isolation represent a highly effective and preferable approach towards overcoming the pandemic, in particular until vaccination rates have risen to the point of herd immunity.
A Review of the Efficiency of White Light (or Other) Emissions in Singly and Co-Doped Dy3+ Ions in Different Host (Phosphate, Silicate, Aluminate) Materials
Authors: Reddy Leelakrishna 
Published: April 2023

AbstractIn this review we will present several research papers pertaining to white colour (or other) emission from Dy3+ doped and undoped phosphor materials. The search for a single component phosphor material that could deliver high quality white light under UV or near UV excitation is an area of active research for commercial purposes. Amongst all rare earth elements Dy3+ is the only ion that could deliver simultaneously blue and yellow light under UV excitation. In optimizing the Yellow/Blue emission intensity ratios, white light emission can be realized. Dy3+ (4f9) displays approximately 4 emission peaks at around 480 nm, 575 nm, 670 and 758 nm corresponding to transitions from the metastable 4F9/2 state to various lower states, such as 6H15/2 (blue), 6H13/2 (yellow), 6H11/2 (red) and 6H9/2 (brownish red), respectively. In general, the hypersensitive transition at 6H13/2 (yellow) is electric dipole in nature and becomes prominent only when Dy3+ ions are positioned at low symmetric sites with no inversion symmetry in the host matrix. On the other hand, the blue magnetic dipole transition at 6H15/2 becomes prominent only when Dy3+ ions are positioned at highly symmetric sites in the host material with inversion symmetry. Despite the white colour emission from the Dy3+ ions, these transitions are mainly associated with parity forbidden 4f -4f transitions, the white light produced maybe diminished at times, hence the need to include a sensitizer to bolster the forbidden transitions experienced by Dy3+ ions. In this review we will focus on the variability of the Yellow/Blue emission intensities in different host materials (phosphates, silicates, and aluminates) from Dy3+ ions (doped or undoped) by studying their photoluminescent properties (PL), their CIE chromaticity coordinates and correlated colour temperature (CCT) values for white colour emissions that is adaptable to different environmental conditions.
Empowerment: Freud, Canguilhem and Lacan on the ideal of health promotion
Authors: de Boer Bas , Aydin Ciano 
Published: April 2023

AbstractEmpowerment is a prominent ideal in health promotion. However, the exact meaning of this ideal is often not made explicit. In this paper, we outline an account of empowerment grounded in the human capacity to adapt and adjust to environmental and societal norms without being completely determined by those norms. Our account reveals a tension at the heart of empowerment between (a) the ability of self-governance and (b) the need to adapt and adjust to environmental and societal norms. We address this tension by drawing from the work of Freud, Canguilhem, and Lacan. First, we clarify through a discussion of Freud’s notion of sublimation that it is difficult to assess empowerment independent of any social valuations, but also that it is no less problematic to make it dependent on social valuations alone. Second, we draw from the work of Canguilhem to show how empowerment can be understood in terms of the individual’s capacity to tolerate the aggressions of a multiplicity of environments. Third, using Lacan, we show how empowerment requires incorporation of social and symbolic norms, without necessarily rendering ourselves a mere product of these norms. Finally, we demonstrate how the views of these authors can complement one another, resulting in a more sophisticated understanding of empowerment.
Exploring the boundaries in an interdisciplinary context through the Family Resemblance Approach: The Dialogue Between Physics and Mathematics
Authors: Satanassi Sara , Branchetti Laura , Fantini Paola , Casarotto Rachele , Caramaschi Martina , Barelli Eleonora , Levrini Olivia 
Published: April 2023

AbstractAmong the relevant aspects of the family resemblance approach (FRA), our study focuses on the potential of the approach to elaborate on disciplinary identities in an interdisciplinary context, specifically regarding the interplay between physics and mathematics. We present and discuss how the FRA wheel can be used and intertwined with the framework of boundary objects and boundary crossing mechanisms (Akkerman & Bakker, Review of Educational Research, 81, 132–169, 2011), which is well-known in STEM education for dealing with interdisciplinarity. The role of the FRA discussed in the article is dual: both practical and theoretical. It is practical in that we show how its use, in combination with the Akkerman and Bakker framework, appears effective in fostering productive discussions among prospective teachers on disciplinary identities and interdisciplinarity in historical cases. It is theoretical in that the combination of the two frameworks provides the vocabulary to characterise the ‘ambiguous nature’ of interdisciplinarity: like boundaries, interdisciplinarity both separates disciplines, making their identities emerge, and connects them, fostering mechanisms of crossing and transgressing the boundaries. This empirical study reveals how the theoretical elaboration took advantage of the prospective teachers’ contributions. We initially presented the FRA to characterise disciplinary identities, but the prospective teachers highlighted its potential to characterise also the boundary zone and the dialogue between physics and mathematics. The data analysis showed that the combinination of the two frameworks shaped a complex learning space where there was room for very different epistemic demands of the prospective teachers: from those who feel better within the identity cores of the disciplines, to those who like to inhabit the boundary zone and others who like to re-shape boundary spaces and move dynamically across them.
Codes of Conduct for Collaboration as Social Rule Systems for Transdisciplinary Processes
Authors: Scholz Roland W. , Renn Ortwin 
Published: April 2023

Abstract
This paper addresses the need for effective and fair codes of conduct for public-good-oriented transdisciplinary processes. These processes are characterized by the production of socially robust orientations (SoROs) through mutual learning and developing better action strategies by merging knowledge from practice and science. We argue that transdisciplinary processes should be governed by an appropriate social rule system that comprises codes of conduct for collaboration (CCC) in transdisciplinary discourses. In our view, participants in a transdisciplinary process must (1) follow rules of mutuality between science and practice (accepting the otherness of the other) and (2) enable the use and integration of knowledge from science and practice (e.g., through responsibility and/or co-leadership at all levels of a project). This requires (3) a protected discourse arena similar to an expanded Chatham House Rule that facilitates the generation of groundbreaking, novel ideas for sustainable transition. In transdisciplinary processes, CCC are based on these three perspectives and can be explicitly introduced yet require cultural and situational adaptations. Many aspects of transdisciplinary processes, such as legal status (e.g., who owns the data generated, whether it is a group or formal organization), are often unclear and need further investigation.
An experimental investigation of social risk preferences for health
Authors: Attema Arthur E. , L’Haridon Olivier , van de Kuilen Gijs 
Published: April 2023

AbstractIn this paper, we use the risk apportionment technique of Eeckhoudt, Rey and Schlesinger (2007) to study higher order risk preferences for others’ health as well as ex-ante and ex-post inequality preferences for social risky distributions, and their interaction. In an experiment on a sample of university students acting as impartial spectators, we observe risk aversion towards social health losses and a dislike of ex-ante inequality. In addition, evidence for ex-post inequality seeking is much weaker than evidence for ex-ante inequality aversion. Because ex-ante inequality aversion is unrelated to risk aversion, we conclude that simple forms of utilitarianism are not relevant for individual judgment of social risk over health. Last, our investigation of precautionary distribution, which would occur when one particular group in the society suffers from background health risk, shows substantial polarization of preferences.