bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing Specialist Perinatal Mental Health Services: the door of opportunity
Authors: Wrigley M. , O’Riordan F. 
Published: March 2023

AbstractThe development of Specialist Perinatal Mental Health Services in Ireland in recent years (2018–2021) is described. The paper highlights the role of unexpected opportunity in advancing this much needed service for women, infants and their families. It also emphasises the need for funding combined with an implementation mechanism to ensure that the service emerging is true to the Model of Care designed and is available in a uniform manner to women nationally.
Breaking the ice in a conversation: abstract words prompt dialogs more easily than concrete ones
Authors: Fini Chiara , Falcinelli Ilenia , Cuomo Giovanna , Era Vanessa , Candidi Matteo , Tummolini Luca , Mazzuca Claudia , Borghi Anna M. 
Published: March 2023

AbstractAbstract domains of knowledge may have social origins. However, whether abstract concepts (ACs) may also differentially affect communicative interaction and conversation has not been explored. Here, we studied ACs’ communicative functions by collecting in an Italian and an English sample, ratings for concrete concept (CC) and ACs related to three main dimensions: communicative/pragmatic [i.e., Openness to Negotiation (ON), Easiness to Start a Conversation (ESC)], semantic/metacognitive [i.e., Social Metacognition (SM) – perceived need of others, Word Confidence (WC), Contextual Availability (CA)], and emotional–experiential (i.e., Pleasantness, Valence, Familiarity). Overall, Italian participants judged it was easier to start a conversation, the more pleasant, familiar, and positively valenced were rated the concepts. Crucially, at lower values of the emotional–experiential component (i.e., Familiarity in the Italian sample, also Pleasantness and Valence in an English sample), there was an advantage of ACs over CCs in the ESC. Moreover, in the Italian sample, participants rated ACs higher on SM, ON, and lower on WC and CA. Notably, in both the Italian and English sample, ACs with higher ratings on the ESC dimension belonged to the Self-Sociality subcluster. The results offer new insights into the pragmatic aspects linked to ACs’ use.
Broken Circle: Premature Deindustrialization, Chinese Capital Exports, and the Stumbling Development of New Territorial Industrial Complexes
Authors: Neel Phillip 
Published: March 2023

AbstractWhile inherited models of industrial development and the role of Foreign Direct Investment (FDI) in the developmental process associate urbanization and rising industrial output with the industrialization of employment, suggesting that the structural shift to a service-based job market is a sign of developmental “maturity,” such models fail to explain the secular tendency toward “premature deindustrialization” that has become increasingly evident in poor countries worldwide. These models cannot account for the deep bifurcations between output and employment, formality and informality, and industrialization and urbanization observable on the ground in the world's fastest growing cities. Meanwhile, the alternative models of critical development theorists tend to focus on failures of industrial takeoff and classic relations of dependency, none of which adequately account for the phenomenon being observed today. This paper explores an alternate explanation for premature deindustrialization, drawing from Marxian theories of technical change and the secular tendencies of capitalist development. The argument is illustrated with examples taken from the author's field work in Dar es Salaam, Tanzania, and the Pearl River Delta in China. Ultimately, the phenomenon of premature deindustrialization suggests that the great circle of development may collapse under its own contradictions before industrialization circumnavigates the globe.
Combining pMINFLUX, graphene energy transfer and DNA-PAINT for nanometer precise 3D super-resolution microscopy
Authors: Zähringer Jonas , Cole Fiona , Bohlen Johann , Steiner Florian , Kamińska Izabela , Tinnefeld Philip 
Published: March 2023

Abstract3D super-resolution microscopy with nanometric resolution is a key to fully complement ultrastructural techniques with fluorescence imaging. Here, we achieve 3D super-resolution by combining the 2D localization of pMINFLUX with the axial information of graphene energy transfer (GET) and the single-molecule switching by DNA-PAINT. We demonstrate <2 nm localization precision in all 3 dimension with axial precision reaching below 0.3 nm. In 3D DNA-PAINT measurements, structural features, i.e., individual docking strands at distances of 3 nm, are directly resolved on DNA origami structures. pMINFLUX and GET represent a particular synergetic combination for super-resolution imaging near the surface such as for cell adhesion and membrane complexes as the information of each photon is used for both 2D and axial localization information. Furthermore, we introduce local PAINT (L-PAINT), in which DNA-PAINT imager strands are equipped with an additional binding sequence for local upconcentration improving signal-to-background ratio and imaging speed of local clusters. L-PAINT is demonstrated by imaging a triangular structure with 6 nm side lengths within seconds.
The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma
Authors: Morgado-Palacin Lucia , Brown Jessie A. , Martinez Thomas F. , Garcia-Pedrero Juana M. , Forouhar Farhad , Quinn S. Aidan , Reglero Clara , Vaughan Joan , Heydary Yasamin Hajy , Donaldson Cynthia , Rodriguez-Perales Sandra , Allonca Eva , Granda-Diaz Rocio , Fernandez Agustin F. , Fraga Mario F. , Kim Arianna L. , Santos-Juanes Jorge , Owens David M. , Rodrigo Juan P. , Saghatelian Alan , Ferrando Adolfo A. 
Published: March 2023

AbstractThe TINCR (Terminal differentiation-Induced Non-Coding RNA) gene is selectively expressed in epithelium tissues and is involved in the control of human epidermal differentiation and wound healing. Despite its initial report as a long non-coding RNA, the TINCR locus codes for a highly conserved ubiquitin-like microprotein associated with keratinocyte differentiation. Here we report the identification of TINCR as a tumor suppressor in squamous cell carcinoma (SCC). TINCR is upregulated by UV-induced DNA damage in a TP53-dependent manner in human keratinocytes. Decreased TINCR protein expression is prevalently found in skin and head and neck squamous cell tumors and TINCR expression suppresses the growth of SCC cells in vitro and in vivo. Consistently, Tincr knockout mice show accelerated tumor development following UVB skin carcinogenesis and increased penetrance of invasive SCCs. Finally, genetic analyses identify loss-of-function mutations and deletions encompassing the TINCR gene in SCC clinical samples supporting a tumor suppressor role in human cancer. Altogether, these results demonstrate a role for TINCR as protein coding tumor suppressor gene recurrently lost in squamous cell carcinomas.
Double dome structure of the Bose–Einstein condensation in diluted S = 3/2 quantum magnets
Authors: Watanabe Yoshito , Miyake Atsushi , Gen Masaki , Mizukami Yuta , Hashimoto Kenichiro , Shibauchi Takasada , Ikeda Akihiko , Tokunaga Masashi , Kurumaji Takashi , Tokunaga Yusuke , Arima Taka-hisa 
Published: March 2023

AbstractBose–Einstein condensation (BEC) in quantum magnets, where bosonic spin excitations condense into ordered ground states, is a realization of BEC in a thermodynamic limit. Although previous magnetic BEC studies have focused on magnets with small spins of S ≤ 1, larger spin systems potentially possess richer physics because of the multiple excitations on a single site level. Here, we show the evolution of the magnetic phase diagram of S = 3/2 quantum magnet Ba2CoGe2O7 when the averaged interaction J is controlled by a dilution of magnetic sites. By partial substitution of Co with nonmagnetic Zn, the magnetic order dome transforms into a double dome structure, which can be explained by three kinds of magnetic BECs with distinct excitations. Furthermore, we show the importance of the randomness effects induced by the quenched disorder: we discuss the relevance of geometrical percolation and Bose/Mott glass physics near the BEC quantum critical point.
Polymerizable rotaxane hydrogels for three-dimensional printing fabrication of wearable sensors
Authors: Xiong Xueru , Chen Yunhua , Wang Zhenxing , Liu Huan , Le Mengqi , Lin Caihong , Wu Gang , Wang Lin , Shi Xuetao , Jia Yong-Guang , Zhao Yanli 
Published: March 2023

AbstractWhile hydrogels enable a variety of applications in wearable sensors and electronic skins, they are susceptible to fatigue fracture during cyclic deformations owing to their inefficient fatigue resistance. Herein, acrylated β-cyclodextrin with bile acid is self-assembled into a polymerizable pseudorotaxane via precise host-guest recognition, which is photopolymerized with acrylamide to obtain conductive polymerizable rotaxane hydrogels (PR-Gel). The topological networks of PR-Gel enable all desirable properties in this system due to the large conformational freedom of the mobile junctions, including the excellent stretchability along with superior fatigue resistance. PR-Gel based strain sensor can sensitively detect and distinguish large body motions and subtle muscle movements. The three-dimensional printing fabricated sensors of PR-Gel exhibit high resolution and altitude complexity, and real-time human electrocardiogram signals are detected with high repeating stability. PR-Gel can self-heal in air, and has highly repeatable adhesion to human skin, demonstrating its great potential in wearable sensors.
Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
Authors: Wang Xudong , Neale Chris , Kim Soo-Kyung , Goddard William A. , Ye Libin 
Published: March 2023

AbstractUnderstanding the roles of intermediate states in signaling is pivotal to unraveling the activation processes of G protein-coupled receptors (GPCRs). However, the field is still struggling to define these conformational states with sufficient resolution to study their individual functions. Here, we demonstrate the feasibility of enriching the populations of discrete states via conformation-biased mutants. These mutants adopt distinct distributions among five states that lie along the activation pathway of adenosine A2A receptor (A2AR), a class A GPCR. Our study reveals a structurally conserved cation-π lock between transmembrane helix VI (TM6) and Helix8 that regulates cytoplasmic cavity opening as a “gatekeeper” for G protein penetration. A GPCR activation process based on the well-discerned conformational states is thus proposed, allosterically micro-modulated by the cation-π lock and a previously well-defined ionic interaction between TM3 and TM6. Intermediate-state-trapped mutants will also provide useful information in relation to receptor-G protein signal transduction.
C–N bond formation by a polyketide synthase
Authors: Wang Jialiang , Wang Xiaojie , Li Xixi , Kong LiangLiang , Du Zeqian , Li Dandan , Gou Lixia , Wu Hao , Cao Wei , Wang Xiaozheng , Lin Shuangjun , Shi Ting , Deng Zixin , Wang Zhijun , Liang Jingdan 
Published: March 2023

AbstractAssembly-line polyketide synthases (PKSs) are molecular factories that produce diverse metabolites with wide-ranging biological activities. PKSs usually work by constructing and modifying the polyketide backbone successively. Here, we present the cryo-EM structure of CalA3, a chain release PKS module without an ACP domain, and its structures with amidation or hydrolysis products. The domain organization reveals a unique “∞”-shaped dimeric architecture with five connected domains. The catalytic region tightly contacts the structural region, resulting in two stabilized chambers with nearly perfect symmetry while the N-terminal docking domain is flexible. The structures of the ketosynthase (KS) domain illustrate how the conserved key residues that canonically catalyze C–C bond formation can be tweaked to mediate C–N bond formation, revealing the engineering adaptability of assembly-line polyketide synthases for the production of novel pharmaceutical agents.
The dynamic nature of percolation on networks with triadic interactions
Authors: Sun Hanlin , Radicchi Filippo , Kurths Jürgen , Bianconi Ginestra 
Published: March 2023

AbstractPercolation establishes the connectivity of complex networks and is one of the most fundamental critical phenomena for the study of complex systems. On simple networks, percolation displays a second-order phase transition; on multiplex networks, the percolation transition can become discontinuous. However, little is known about percolation in networks with higher-order interactions. Here, we show that percolation can be turned into a fully fledged dynamical process when higher-order interactions are taken into account. By introducing signed triadic interactions, in which a node can regulate the interactions between two other nodes, we define triadic percolation. We uncover that in this paradigmatic model the connectivity of the network changes in time and that the order parameter undergoes a period doubling and a route to chaos. We provide a general theory for triadic percolation which accurately predicts the full phase diagram on random graphs as confirmed by extensive numerical simulations. We find that triadic percolation on real network topologies reveals a similar phenomenology. These results radically change our understanding of percolation and may be used to study complex systems in which the functional connectivity is changing in time dynamically and in a non-trivial way, such as in neural and climate networks.
Photothermally induced natural vibration for versatile and high-speed actuation of crystals
Authors: Hagiwara Yuki , Hasebe Shodai , Fujisawa Hiroki , Morikawa Junko , Asahi Toru , Koshima Hideko 
Published: March 2023

AbstractThe flourishing field of soft robotics requires versatile actuation methodology. Natural vibration is a physical phenomenon that can occur in any material. Here, we report high-speed bending of anisole crystals by natural vibration induced by the photothermal effect. Rod-shaped crystal cantilevers undergo small, fast repetitive bending (~0.2°) due to natural vibration accompanied by large photothermal bending (~1°) under ultraviolet light irradiation. The natural vibration is greatly amplified by resonance upon pulsed light irradiation at the natural frequency to realise high frequency (~700 Hz), large bending (~4°), and high energy conversion efficiency from light to mechanical energy. The natural vibration is induced by the thermal load generated by the temperature gradient in the crystal due to the photothermal effect. The bending behaviour is successfully simulated using finite element analysis. Any light-absorbing crystal can be actuated by photothermally induced natural vibration. This finding of versatile crystal actuation can lead to the development of soft robots with high-speed and high-efficient actuation capabilities.
Finite element modeling of meniscal tears using continuum damage mechanics and digital image correlation
Authors: Nesbitt Derek Q. , Burruel Dylan E. , Henderson Bradley S. , Lujan Trevor J. 
Published: March 2023

AbstractMeniscal tears are a common, painful, and debilitating knee injury with limited treatment options. Computational models that predict meniscal tears may help advance injury prevention and repair, but first these models must be validated using experimental data. Here we simulated meniscal tears with finite element analysis using continuum damage mechanics (CDM) in a transversely isotropic hyperelastic material. Finite element models were built to recreate the coupon geometry and loading conditions of forty uniaxial tensile experiments of human meniscus that were pulled to failure either parallel or perpendicular to the preferred fiber orientation. Two damage criteria were evaluated for all experiments: von Mises stress and maximum normal Lagrange strain. After we successfully fit all models to experimental force–displacement curves (grip-to-grip), we compared model predicted strains in the tear region at ultimate tensile strength to the strains measured experimentally with digital image correlation (DIC). In general, the damage models underpredicted the strains measured in the tear region, but models using von Mises stress damage criterion had better overall predictions and more accurately simulated experimental tear patterns. For the first time, this study has used DIC to expose strengths and weaknesses of using CDM to model failure behavior in soft fibrous tissue.
Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal membrane oxygenation
Authors: Rozencwajg Sacha , Heinsar Silver , Wildi Karin , Jung Jae‐Seung , Colombo Sebastiano Maria , Palmieri Chiara , Sato Kei , Ainola Carmen , Wang Xiaomeng , Abbate Gabriella , Sato Noriko , Dyer Wayne B. , Livingstone Samantha , Helms Leticia , Bartnikowski Nicole , Bouquet Mahe , Passmore Margaret R. , Hyslop Kieran , Vidal Bruno , Reid Janice D. , McGuire Daniel , Wilson Emily S. , Rätsep Indrek , Lorusso Roberto , Schmidt Matthieu , Suen Jacky Y. , Bassi Gianluigi Li , Fraser John F. 
Published: March 2023

AbstractDifferential hypoxaemia (DH) is common in patients supported by femoral veno-arterial extracorporeal membrane oxygenation (V-A ECMO) and can cause cerebral hypoxaemia. To date, no models have studied the direct impact of flow on cerebral damage. We investigated the impact of V-A ECMO flow on brain injury in an ovine model of DH. After inducing severe cardiorespiratory failure and providing ECMO support, we randomised six sheep into two groups: low flow (LF) in which ECMO was set at 2.5 L min−1 ensuring that the brain was entirely perfused by the native heart and lungs, and high flow (HF) in which ECMO was set at 4.5 L min−1 ensuring that the brain was at least partially perfused by ECMO. We used invasive (oxygenation tension—PbTO2, and cerebral microdialysis) and non-invasive (near infrared spectroscopy—NIRS) neuromonitoring, and euthanised animals after five hours for histological analysis. Cerebral oxygenation was significantly improved in the HF group as shown by higher PbTO2 levels (+ 215% vs − 58%, p = 0.043) and NIRS (67 ± 5% vs 49 ± 4%, p = 0.003). The HF group showed significantly less severe brain injury than the LF group in terms of neuronal shrinkage, congestion and perivascular oedema (p < 0.0001). Cerebral microdialysis values in the LF group all reached the pathological thresholds, even though no statistical difference was found between the two groups. Differential hypoxaemia can lead to cerebral damage after only a few hours and mandates a thorough neuromonitoring of patients. An increase in ECMO flow was an effective strategy to reduce such damages.
Advanced quantum image representation and compression using a DCT-EFRQI approach
Authors: Haque Md Ershadul , Paul Manoranjan , Ulhaq Anwaar , Debnath Tanmoy 
Published: March 2023

AbstractIn recent years, quantum image computing draws a lot of attention due to storing and processing image data faster compared to classical computers. A number of approaches have been proposed to represent the quantum image inside a quantum computer. Representing and compressing medium and big-size images inside the quantum computer is still challenging. To address this issue, we have proposed a block-wise DCT-EFRQI (Direct Cosine Transform Efficient Flexible Representation of Quantum Image) approach to represent and compress the gray-scale image efficiently to save computational time and reduce the quantum bits (qubits) for the state preparation. In this work, we have demonstrated the capability of block-wise DCT and DWT transformation inside the quantum domain to investigate their relative performances. The Quirk simulation tool is used to design the corresponding quantum image circuit. In the proposed DCT-EFRQI approach, a total of 17 qubits are used to represent the coefficients, the connection between coefficients and state (i.e., auxiliary), and their position for representing and compressing grayscale images inside a quantum computer. Among those, 8 qubits are used to map the coefficient values and the rest are used to generate the corresponding coefficient XY-coordinate position including one auxiliary qubit. Theoretical analysis and experimental results show that the proposed DCT-EFRQI scheme provides better representation and compression compared to DCT-GQIR, DWT-GQIR, and DWT-EFRQI in terms of rate-distortion performance.
Identifying polymorphic cis-regulatory variants as risk markers for lung carcinogenesis and chemotherapy responses in tobacco smokers from eastern India
Authors: Sengupta Debmalya , Mukhopadhyay Pramiti , Banerjee Souradeep , Ganguly Kausik , Mascharak Prateek , Mukherjee Noyonika , Mitra Sangeeta , Bhattacharjee Samsiddhi , Mitra Ritabrata , Sarkar Abhijit , Chaudhuri Tamohan , Bhattacharjee Gautam , Nath Somsubhra , Roychoudhury Susanta , Sengupta Mainak 
Published: March 2023

AbstractAberrant expression of xenobiotic metabolism and DNA repair genes is critical to lung cancer pathogenesis. This study aims to identify the cis-regulatory variants of the genes modulating lung cancer risk among tobacco smokers and altering their chemotherapy responses. From a list of 2984 SNVs, prioritization and functional annotation revealed 22 cis-eQTLs of 14 genes within the gene expression-correlated DNase I hypersensitive sites using lung tissue-specific ENCODE, GTEx, Roadmap Epigenomics, and TCGA datasets. The 22 cis-regulatory variants predictably alter the binding of 44 transcription factors (TFs) expressed in lung tissue. Interestingly, 6 reported lung cancer-associated variants were found in linkage disequilibrium (LD) with 5 prioritized cis-eQTLs from our study. A case–control study with 3 promoter cis-eQTLs (p < 0.01) on 101 lung cancer patients and 401 healthy controls from eastern India with confirmed smoking history revealed an association of rs3764821 (ALDH3B1) (OR = 2.53, 95% CI = 1.57–4.07, p = 0.00014) and rs3748523 (RAD52) (OR = 1.69, 95% CI = 1.17–2.47, p = 0.006) with lung cancer risk. The effect of different chemotherapy regimens on the overall survival of lung cancer patients to the associated variants showed that the risk alleles of both variants significantly decreased (p < 0.05) patient survival.