bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empfehlung für Fragebögen zur Untersuchung der Schultergelenkfunktion vom Research-Komitee der AGA
Authors: Wafaisade Arasch , Akgün Doruk , Günther Daniel , Laky Brenda , Mathis Dominic , Deichsel Adrian , Ackermann Jakob , Schüttler Karl Friedrich , Eggeling Lena , Kopf Sebastian , Herbst Elmar 
Published: May 2023

ZusammenfassungIn der Orthopädie und Unfallchirurgie hat die Bedeutung von PROMs („patient-reported outcome measures“) nicht nur klinisch und akademisch, sondern auch gesundheitspolitisch enorm zugenommen. Am Schultergelenk existieren zahlreiche solcher Messinstrumente, sodass für den Vergleich in Wissenschaft und Klinik eine einheitliche Verwendung geeigneter PROMs zu empfehlen ist. Ein PROM sollte wissenschaftliche Kriterien (u. a. Reliabilität, Validität, Responsiveness) erfüllen sowie in der jeweiligen Landessprache und nicht nur für die jeweilige Pathologie validiert sein. Zudem sollten Daten zur „minimal clinically important difference“ (MCID) vorliegen, um Ergebnisse nicht nur hinsichtlich ihrer statistischen Signifikanz, sondern auch der klinischen Relevanz beurteilen zu können. Ziel dieser Arbeit war es, für relevante Pathologien des Schultergelenks jeweils einen PROM zu empfehlen, der die o. g. Kriterien am besten erfüllt. Für das Schultergelenk werden dabei vom Research-Komitee der AGA unter Berücksichtigung dieser Kriterien folgende PROMs empfohlen: Constant-Murley-Score (CMS) für die Omarthrose bzw. Schulterendoprothetik, Western Ontario Stability Index (WOSI) für glenohumerale Instabilitäten und Western Ontario Rotator Cuff Index (WORCI) für Pathologien des Subakromialraums bzw. von Rotatorenmanschettenläsionen. Der Nottingham Clavicle Score (NCS) stellt ein geeignetes Instrument für die Klavikula sowie die angrenzenden Gelenke (Akromioklavikular- und Sternoklavikulargelenk) dar. Diese empfohlenen PROMs decken eine große Bandbreite an Schulterpathologien ab, sind bzgl. obiger Kriterien qualitativ hochwertig und für die deutsche Sprache validiert.
A comprehensive review on the medicinally valuable endosymbiotic fungi Penicillium chrysogenum
Authors: Shaaban Rawan , Elnaggar Mohamed S. , Khalil Noha , Singab Abdel Nasser B. 
Published: May 2023

AbstractRecently, it has been shown that metabolites derived from endosymbiotic fungi attracted high attention, since plenty of them have promising pharmaceutical applications. The variation of metabolic pathways in fungi is considered an optimistic source for lead compounds. Among these classes are terpenoids, alkaloids, polyketides, and steroids, which have proved several pharmacological activities, including antitumor, antimicrobial, anti-inflammatory, and antiviral actions. This review concludes the major isolated compounds from different strains of Penicillium chrysogenum during the period 2013–2023, together with their reported pharmacological activities. From literature surveys, 277 compounds have been identified from P. chrysogenum, which has been isolated as an endosymbiotic fungus from different host organisms, with specific attention paid to those showing marked biological activities that could be useful in the pharmaceutical industry in the future. This review represents documentation for a valuable reference for promising pharmaceutical applications or further needed studies on P. chrysogenum.
Comparative in vivo toxicokinetics of silver powder, nanosilver and soluble silver compounds after oral administration to rats
Authors: Mertens Jelle , Alami Anissa , Arijs Katrien 
Published: May 2023

AbstractSilver (Ag; massive, powder and nanoform) and Ag compounds are used in industrial, medical and consumer applications, with potential for human exposure. Uncertainties exist about their comparative mammalian toxicokinetic (‘TK’) profiles, including their relative oral route bioavailability, especially for Ag massive and powder forms. This knowledge gap impedes concluding on the grouping of Ag and Ag compounds for hazard assessment purposes. Therefore, an in vivo TK study was performed in a rat model. Sprague–Dawley rats were exposed via oral gavage for up to 28 days to silver acetate (AgAc; 5, 55, 175 mg/kg(bw)/d), silver nitrate (AgNO3; 5, 55, 125 mg/kg(bw)/d), nanosilver (AgNP; 15 nm diameter; 3.6, 36, 360 mg/kg(bw)/d) or silver powder (AgMP; 0.35 µm diameter; 36, 180, 1000 mg/kg(bw)/d). Total Ag concentrations were determined in blood and tissues to provide data on comparative systemic exposure to Ag and differentials in achieved tissue Ag levels. AgAc and AgNO3 were the most bioavailable forms with comparable and linear TK profiles (achieved systemic exposures and tissue concentrations). AgMP administration led to systemic exposures of about an order of magnitude less, with tissue Ag concentrations 2–3 orders of magnitude lower and demonstrating non-linear kinetics. The apparent oral bioavailability of AgNP was intermediate between AgAc/AgNO3 and AgMP. For all test items, highest tissue Ag concentrations were in the gastrointestinal tract and reticuloendothelial organs, whereas brain and testis were minor sites of distribution. It was concluded that the oral bioavailability of AgMP was very limited. These findings provide hazard assessment context for various Ag test items and support the prediction that Ag in massive and powder forms exhibit low toxicity potential.
The vestibular calyceal junction is dismantled following subchronic streptomycin in rats and sensory epithelium stress in humans
Authors: Maroto Alberto F. , Borrajo Mireia , Prades Sílvia , Callejo Àngela , Amilibia Emilio , Pérez-Grau Marta , Roca-Ribas Francesc , Castellanos Elisabeth , Barrallo-Gimeno Alejandro , Llorens Jordi 
Published: May 2023

AbstractHair cell (HC) loss by epithelial extrusion has been described to occur in the rodent vestibular system during chronic 3,3′-iminodipropionitrile (IDPN) ototoxicity. This is preceded by dismantlement of the calyceal junction in the contact between type I HC (HCI) and calyx afferent terminals. Here, we evaluated whether these phenomena have wider significance. First, we studied rats receiving seven different doses of streptomycin, ranging from 100 to 800 mg/kg/day, for 3–8 weeks. Streptomycin caused loss of vestibular function associated with partial loss of HCI and decreased expression of contactin-associated protein (CASPR1), denoting calyceal junction dismantlement, in the calyces encasing the surviving HCI. Additional molecular and ultrastructural data supported the conclusion that HC-calyx detachment precede HCI loss by extrusion. Animals allowed to survive after the treatment showed functional recuperation and rebuilding of the calyceal junction. Second, we evaluated human sensory epithelia obtained during therapeutic labyrinthectomies and trans-labyrinthine tumour excisions. Some samples showed abnormal CASPR1 label strongly suggestive of calyceal junction dismantlement. Therefore, reversible dismantlement of the vestibular calyceal junction may be a common response triggered by chronic stress, including ototoxic stress, before HCI loss. This may partly explain clinical observations of reversion in function loss after aminoglycoside exposure.
Exceptional collections for mirrors of invertible polynomials
Authors: Favero David , Kaplan Daniel , Kelly Tyler L. 
Published: May 2023

AbstractWe prove the existence of a full exceptional collection for the derived category of equivariant matrix factorizations of an invertible polynomial with its maximal symmetry group. This proves a conjecture of Hirano–Ouchi. In the Gorenstein case, we also prove a stronger version of this conjecture due to Takahashi. Namely, that the full exceptional collection is strong.
Therapy results in pediatric Hodgkin lymphoma — does less mean better? Experience from a single children’s oncology center
Authors: Stankiewicz Joanna , Kołtan Andrzej , Demidowicz Ewa , Bartoszewicz Natalia , Kołtan Sylwia , Czyżewski Krzysztof , Richert-Przygońska Monika , Dębski Robert , Pogorzała Monika , Tejza Barbara , Cisek Joanna , Księżniakiewicz Piotr , Jatczak-Gaca Agnieszka , Marjańska Agata , Salamon Marlena , Dąbrowska Anna , Urbańczyk Anna , Grześk Elżbieta , Jaremek Kamila , Łęcka Monika , Grochowska Oliwia , Styczyński Jan 
Published: May 2023

Abstract
Therapy results in pediatric Hodgkin lymphoma reflect remarkable progress in pediatric oncology. In the last decade, relevant development of new therapeutic options for children with refractory or relapsed disease has been made. In this study, we retrospectively analyzed therapy results and risk factors in children treated in a single oncology center according to five therapeutic protocols. Data from 114 children treated by a single institution between 1997 and 2022 were analyzed. Classic Hodgkin lymphoma therapy results were divided into four therapeutic periods: 1997–2009, 2009–2014, 2014–2019, and 2019–2022. For nodular lymphocyte-predominant Hodgkin lymphoma, data from one therapeutic protocol was analyzed. For the entire group, the 5-year probability of overall survival was 93.5%. There were no statistically significant differences between therapeutic periods. The occurrence of B symptoms at diagnosis and incidence of relapse were risk factors for death (p = 0.018 and p < 0.001). Relapse occurred in 5 cases. The 5-year probability of relapse-free survival for the entire group was 95.2%, without significant differences between groups. Patients treated between 1997 and 2009 had over a sixfold higher risk for events, defined as primary progression, relapse, death, or incidence of secondary malignancies (OR = 6.25, p = 0.086). The 5-year probability of event-free survival for all patients was 91.3%. Five patients died, and the most common cause of death was relapse. Modern therapeutic protocols in pediatric Hodgkin lymphoma are marked by excellent outcomes. Patients with disease relapses have a notably high risk of death, and the development of new therapeutic options for this group remains one of the main goals of current trials.
The accuracy of cystoscopy in predicting muscle invasion in newly diagnosed bladder cancer patients
Authors: van Straten Christine G. J. I. , Bruins Max H. , Dijkstra Siebren , Cornel Erik B. , Kortleve Michael D. H. , de Vocht Thijn F. , Kiemeney Lambertus A. L. M. , van der Heijden Antoine G. 
Published: May 2023

Abstract
Purpose
The prognosis of muscle-invasive bladder cancer (MIBC) has not improved for three decades. Transurethral resection of the bladder tumor (TURBT) is the standard procedure for local tumor staging. TURBT has several limitations, including the spread of tumor cells. Therefore, an alternative is needed in patients with suspected MIBC. Recent studies have shown that mpMRI is very accurate in staging bladder tumors. Because the diagnostic efficacy of urethrocystoscopy (UCS) has been reported as good as the efficacy of mpMRI to predict muscle invasion we performed this prospective multicenter study in which we compare UCS with pathology.

Methods
From July 2020 until March 2022, 321 patients with suspected primary BC in seven participating Dutch hospitals were included in this study. A flexible UCS was performed by urologists, physician assistants, or residents. Predictions of muscle invasion using a 5-point Likert scale alongside the histopathology data were recorded. The sensitivity, specificity, predictive values, and 95% confidence intervals were determined using a standard contingency table.

Results
Of the 321 included patients, 232 (72.3%) received a histopathological diagnosis of non-muscle-invasive bladder cancer (NMIBC) and 71 (22.1%) were histopathologically diagnosed as MIBC. In 2 patients (0.6%), classification was not possible (Tx). Cystoscopy predicted muscle invasion with a sensitivity of 71.8% (95% CI 59.9–81.9), and a specificity of 89.9% (95% CI 85.4–93.3). This corresponds to a positive predictive value (PPV) of 67.1% and a negative predictive value (NPV) of 91.7%.

Conclusion
Our study shows a moderate accuracy of cystoscopy to predict muscle invasion. This result does not support the use of cystoscopy only instead of TURBT for local staging.
Internal validation study to assess the SeqStudio™ for human identification’s performance
Authors: Soldati Giulia , Turrina Stefania , Saccardo Chiara , Ausania Francesco , De Leo Domenico 
Published: May 2023

AbstractThe SeqStudio™ for human identification (HID) is a new benchtop capillary electrophoresis (CE) platform recently developed by Applied Biosystems for genotyping and sequencing short tandem repeat (STR) fragments. Compared to the previous series of CE systems developed by this maker, it is more compact and easier to use. Moreover, by allowing the detection of 4 to 8 fluorescent dyes, it seems to be fully compatible with the different kits of autosomal and gonosomal STR markers usually used in forensic genetics, which are available in trade and supplied by various manufacturers. However, being a new CE model, before its routine use in forensic genetics applications, it should undergo appropriate analytical validation studies in its own laboratories to understand its potential and limitations. A series of experiments on DNA samples coming from cell line controls, using the GlobalFiler™ IQC Amplification Kit, were carried out to meet this purpose. The SeqStudio™ Genetic Analyzer for HID’s findings on genotyping reproducibility (precision and accuracy of sizing), sensitivity, signal variability between dyes (intra- and inter-color channel balance), and stutter ratios are reported. These findings confirm the validity of this new CE system and its capability to generate reliable results.
Detection of novel loci involved in non-seed-shattering behaviour of an indica rice cultivar, Oryza sativa IR36
Authors: Sugiyama Shohei , Sakuta Motoki , Tsujimura Yuki , Yamaguchi Yudai , Htun Than Myint , Inoue Chizuru , Numaguchi Koji , Ishii Takashige , Ishikawa Ryo 
Published: May 2023

AbstractAsian rice (Oryza sativa) was domesticated from O. rufipogon, and reduced seed-shattering behaviour was selected to increase yields. Two seed-shattering loci, qSH3 and sh4, are involved in reducing seed shattering in both japonica and indica rice cultivars, while qSH1 and qCSS3 are likely specific to japonica cultivars. In indica cultivars, qSH3 and sh4 fail to explain the degree of seed shattering, as an introgression line (IL) of O. rufipogon W630 carrying domesticated alleles at qSH3 and sh4 still showed seed shattering. Here we analysed differences in seed-shattering degree between the IL and the indica cultivar IR36. The values for grain detachment in the segregating population between the IL and IR36 were continuous. Based on QTL-seq analysis using the BC1F2 population between the IL and IR36, we detected two novel loci, qCSS2 and qCSS7 (QTLs for the Control of Seed Shattering in rice on chromosomes 2 and 7), which contributed to the reduced seed shattering in IR36. We further investigated the genetic interaction of qCSS2 and qCSS7 under the presence of qSH3 and sh4 mutations in O. rufipogon W630 and found that IL carrying IR36 chromosomal segments covering all four loci are required to explain seed-shattering degree in IR36. Since qCSS2 and qCSS7 were not detected in previous studies on seed shattering in japonica, their control may be specific to indica cultivars. Therefore, they are important to understanding the history of rice domestication as well as to adjusting the seed-shattering degree of indica cultivars to maximise their yield.
The importance of inflammatory biomarkers in non-specific acute and chronic low back pain: a systematic review
Authors: Pinto Eduardo Moreira , Neves João Rocha , Laranjeira Manuel , Reis Joaquim 
Published: May 2023

Abstract
Objective
The purpose of this study was to systematically review the evidence on inflammatory biomarkers as analytic predictors of non-specific low back pain (NsLBP).

Summary of background data
Low back pain (LBP) is the number one cause of disability globally, posing a major health problem that causes an enormous social and economic burden, and there is an increasing interest on the importance of biomarkers in quantifying and even emerge as potential therapeutic tools to LBP.

Methods
A systematic search was conducted on July 2022 in Cochrane Library, MEDLINE and Web of Science for all the available literature. Cross-sectional, longitudinal cohort or case–control studies that evaluated the relationship between inflammatory biomarkers collected from blood samples and low back pain in humans were considered eligible for inclusion, as well as prospective and retrospective studies.

Results
The systematic database search resulted in a total of 4016 records, of which 15 articles were included for synthesis. Sample size comprised a total of 14,555 patients with LBP (acute LBP (n = 2073); chronic LBP (n = 12482)) and 494 controls. Most studies found a positive correlation between classic pro-inflammatory biomarkers and NsLBP, namely C-reactive protein (CRP), interleukin 1 (IL-1) and IL-1β, interleukin 6 (IL-6) and tumour necrosis factor α (TNF-α). On the other hand, anti-inflammatory biomarker interleukin 10 (IL-10) demonstrated a negative association with NsLBP. Four studies have made direct comparisons between ALBP and CLBP groups regarding their inflammatory biomarkers profile.

Conclusions
This systematic review found evidence of increased levels of pro-inflammatory biomarkers CRP, IL-6 and TNF-α and decreased levels of anti-inflammatory biomarker IL-10 in patients with LBP. Hs-CRP was not correlated with LBP. There is insufficient evidence to associate these findings with the degree of pain severity or the activity status of the lumbar pain over time.
Optimization of a non-activating medium for short-term chilled storage of barramundi (Lates calcarifer) testicular spermatozoa
Authors: Marc Adrien F. , Guppy Jarrod L. , Marshall Hayley , Jerry Dean R. , Rudd Donna , Paris Damien B. B. P. 
Published: May 2023

AbstractReliable short-term chilled sperm storage is a critical prerequisite to using advanced reproductive techniques for captive breeding of barramundi (Asian sea bass; Lates calcarifer). Marine Ringer's solution (MRS) is a common non-activating medium (NAM) and has previously been used to store sperm from wild-caught barramundi. However, MRS-stored spermatozoa from captive-bred barramundi were observed to lyse within 30 min incubation. Therefore, this study aimed to optimize the composition of NAM for short-term chilled storage by characterizing and mimicking the biochemical profile of seminal and blood plasma of captive-bred barramundi. To further understand the effect of each component, osmolality was first examined to determine its effect on sperm viability. Thereafter, the effects of NaHCO3, pH, and Na+ and K+ concentrations on sperm motility were investigated. Optimization of the NAM formula was achieved through iterative adaptions. The increase in NAM osmolality from 260 to 400 mOsm/kg led to a significant improvement in sperm viability. Moreover, using HEPES instead of NaHCO3 as buffering agent significantly enhanced sperm motility and velocity. As a result, sperm samples diluted with optimized NAM (185 mM NaCl, 5.1 mM KCl, 1.6 mM CaCl2·2H2O, 1.1 mM MgSO4·7H2O, 10.0 mM HEPES, 5.6 mM D+ glucose, 400 mOsm/kg, pH 7.4) and stored at 4 °C showed no significant loss in total motility for up to 48 h and retained progressive motility for up to 72 h. The optimized NAM developed in this study significantly extended the functional lifespan of spermatozoa during chilled storage, permitting the ongoing development of advanced reproductive technologies for barramundi.
A two-field approach to multibody dynamics of rotating flexible bodies
Authors: Géradin Michel , Sonneville Valentin 
Published: May 2023

AbstractA two-field version of the floating frame-of-reference approach is developed to describe the dynamics of a flexible body in the case of motion in a uniformly rotating frame. Full decoupling of the kinetic energy results from splitting of the motion into rigid-body modes of the floating center of mass and a velocity field orthogonal to them. The motion equations are developed from a canonical variational expression in which displacement and velocity fields play independent roles. They turn out to keep the same global structure as in the case of motion in an inertial frame. The discretization of all inertia terms is discussed in depth. It is also shown that, in the case of discretization of the continuum with 3D solid elements, all gyroscopic terms can be derived from a mass kernel and associated $\mathbf{S} _{i}$

S
i

matrices. Model reduction is proposed using the Herting–Martinez method in order to automatically satisfy orthogonality of the velocity field to rigid-body modes. Two application examples of high-speed rotating systems are developed at length to assess the efficiency of the proposed methodology.
Is There a Pervasive World Real Credit Cycle?
Authors: Castro Vítor , Cerqueira Pedro A. , Martins Rodrigo 
Published: May 2023

AbstractThis paper analyses the international structure of credit and the potential buildup of a single world cycle using quarterly data for 48 economies between 1985 and 2015. For this analysis, we rely on an approximate factor model and on hard and fuzzy clustering methodologies. The results indicate that, for the whole sample, there are three common components to credit, one of these more pervasive and impacting most countries in the sample, particularly developed ones. One major cluster of countries is identified, but without the presence of both Japan and Germany, thus suggesting that a world real credit cycle is not yet formed. However, we found that the composition of this core cluster has been growing over the years, encompassing more countries and establishing a growing dominance over the credit cycles dynamic, opening the possibility for a single world credit cycle in the future.
Bounded rationality for relaxing best response and mutual consistency: the quantal hierarchy model of decision making
Authors: Evans Benjamin Patrick , Prokopenko Mikhail 
Published: May 2023

AbstractWhile game theory has been transformative for decision making, the assumptions made can be overly restrictive in certain instances. In this work, we investigate some of the underlying assumptions of rationality, such as mutual consistency and best response, and consider ways to relax these assumptions using concepts from level-k reasoning and quantal response equilibrium (QRE) respectively. Specifically, we propose an information-theoretic two-parameter model called the quantal hierarchy model, which can relax both mutual consistency and best response while still approximating level-k, QRE, or typical Nash equilibrium behavior in the limiting cases. The model is based on a recursive form of the variational free energy principle, representing higher-order reasoning as (pseudo) sequential decision-making in extensive-form game tree. This representation enables us to treat simultaneous games in a similar manner to sequential games, where reasoning resources deplete throughout the game-tree. Bounds in player processing abilities are captured as information costs, where future branches of reasoning are discounted, implying a hierarchy of players where lower-level players have fewer processing resources. We demonstrate the effectiveness of the quantal hierarchy model in several canonical economic games, both simultaneous and sequential, using out-of-sample modelling.