bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between Femoral Head Lateralization and Bone Morphology in Primary Hip Osteoarthritis
Authors: Inagaki Kenta , Hagiwara Shigeo , Kawarai Yuya , Terakawa Hiroakira , Miyamoto Shuichi , Suzuki Chiho , Yamagata Hiroyuki , Nakamura Junichi , Ohtori Seiji , Iida Satoshi 
Published: August 2023

Background. Osteoarthritis (OA) is the most common disease of the hip in adults, and its etiology is divided into two groups: primary and secondary. Although acetabular dysplasia is the most frequent reason for total hip arthroplasty (THA) in Japan, primary OA has increased recently. Although there are two types of femoral head migration in primary OA: superior and medial, there are some patients with prominent femoral head lateralization. This study aimed at evaluating the relationship between femoral head lateralization and bone morphology of the acetabulum and proximal femur using radiographic factors in primary OA of the hip. Methods. A retrospective study was conducted between 2008 and 2017 to assess 1308 hips with OA who underwent primary THAs at our institute. The diagnostic criteria for primary OA were Crowe type 1, Sharp’s angle <45°, and center-edge (CE) angle >25°. We classified patients with primary OA into two groups based on femoral head lateralization: group L with lateralization or group N without. Radiographic factors included Sharp’s angle, CE angle, acetabular inclination, acetabular depth ratio (ADR), acetabular head index (AHI), and femoral neck-shaft angle (FNA), all examined on an anteroposterior pelvic radiograph. Femoral neck anteversion was calculated using computerized axial tomography. Results. Primary OA was diagnosed in 210/1308 hips (16.1%) (group L: 112 hips (8.6%); group N: 98 (7.5%)). Patient demographics were not significantly different. Radiographic factors with observed significant differences between group L and group N were the average CE angle (33.0° vs. 35.1°, respectively,

p

= 0.009), ADR (251.6 vs. 273.4,

p

< 0.001), AHI (77.2 vs. 80.4,

p

< 0.001), and FNA (136.9° vs. 134.8°,

p

= 0.012). Conclusions. This investigation suggests that primary OA with femoral head lateralization demonstrated specific identifiable radiographic characteristics in the acetabulum and proximal femur that might contribute to hip joint instability such as the dysplastic hip.
Practicality of STAT3 Gene Polymorphisms and Sorafenib Trough Concentration as Biomarkers for Sorafenib-Induced Hand-Foot Skin Reaction in Hepatocellular Carcinoma
Authors: Takatsuka Hirokazu , Sugawara Takato , Uchida Masashi , Yamazaki Shingo , Suzuki Takaaki , Kanogawa Naoya , Ogasawara Sadahisa , Shiko Yuki , Kawasaki Yohei , Kato Naoya , Ishii Itsuko 
Published: August 2023

Introduction. The aim of this study was to evaluate the practicality of the signal transducer and activator of transcription (STAT) 3 polymorphisms as a predictive biomarker and sorafenib trough concentration as a monitoring biomarker for hand-foot skin reaction (HFSR) in patients with hepatocellular carcinoma (HCC). Methods. In total, 43 Japanese HCC patients were included. Sorafenib concentrations were measured, if possible, on days 8, 29, 35, and 57. The sorafenib concentration on day 8 (Cday8) was used for the analysis of HFSR occurring up to day 29. The median concentration for each patient (Cmedian) was used for HFSR occurring up to day 57 (study period). The STAT3 single nucleotide polymorphism (SNP) rs4796793 was determined using cell-free DNA extracted from plasma. Result. The Cday8 tended to be higher in the HFSR onset or grade ≥ 2 HFSR severity group than in the non-HFSR or grade ≤ 1 HFSR severity group. The Cmedian was significantly higher in the HFSR onset or grade ≥ 2 group than in the non-HFSR or grade ≤ 1 HFSR group. The Cmedian thresholds for predicting HFSR onset and severity were 3.62 μg/mL and 6.10 μg/mL, respectively. There was no association between STAT3 rs4796793 and HFSR onset or severity. In multivariate analysis, Cmedian values ≥ 3.62 μg/mL and >6.10 μg/mL were associated with the increased risk of HFSR onset (odds ratio: 16.6,

p

< 0.01) and severity (odds ratio: 15.7,

p

< 0.01), respectively. Conclusion. Monitoring of the sorafenib trough concentration may be practical for avoiding HFSR.
Pentecostals and Premillennialist Dispensationalism
Authors: Nel Marius 
Published: August 2023

Abstract
Early Pentecostals believed their experience of Spirit baptism represented the latter rain of prophecy that introduced Christ’s return. Therefore, their goal was to preach the Pentecostal gospel to all, expecting their success to hasten Christ’s return. They read the Bible through the lens of their charismatic experiences and left room for the Spirit, who inspired the Scriptures to explain its meaning. The next generations adopted a fundamentalist hermeneutical angle and included premillennialist dispensationalism to understand biblical prophecies. The doctrines of rapture, premillennialism, and a distinction between Israel and the church imply that the church belongs to the ‘parenthetical age’, indicating a delay in the prophetic timeline when Jews rejected Jesus. It took the emphasis away from the urgent need to evangelise the world, focusing on explaining the biblical ‘last events’ and setting timetables. It is argued that Pentecostals’ dispensationalism betrayed their unique ethos, values, and hermeneutical angle.
Advanced imaging and quantification of the cambium and developing xylem in eucalypts using X-ray micro- and nano-computed tomography
Authors: Schoeman Letitia , Drew David M. 
Published: August 2023

Summary
In recent years, the popularity of X-ray computed tomography (CT), as a non-destructive imaging technique, has continued to expand in various research domains. In wood research, X-ray CT has proven to be useful for three-dimensional (3D) structural studies investigating the complex tissues of trees. Wood formation (i.e., xylogenesis) initiates in the cambium and a narrow zone of subsequent differentiation, both of which play key roles in plant growth and development. However, the dynamics of xylogenesis in eucalypts remain relatively poorly understood, in large part due to challenges in sampling, imaging, and characterizing the cambium. Therefore, the aim of this study was to present a workflow to evaluate the feasibility of using X-ray CT to characterize and quantify the structural properties of the cambium in eucalypts. The growth responses of Corymbia hybrid seedlings, exposed to either irrigated or droughted conditions, was investigated by monitoring the structural development of the cambium. To track microstructural changes in the cambium, the same seedlings were imaged with X-ray micro-CT (μCT) one day before the treatments and again six days after the respective treatments. After the last X-ray μCT scan, X-ray nano-CT was also applied. Using image analysis techniques, the morphological characteristics of the cambium could be determined. X-ray μCT displayed a larger, thicker cambial zone in irrigated plants, while a much thinner cambium was visible in droughted seedlings. X-ray nano-CT revealed that droughted plants were associated with a significantly () smaller cambium volume containing smaller cells, compared to the cambium of irrigated plants. Light microscopy was used to validate the CT results and demonstrated no significant () difference in the cambium width and cell diameter obtained from the two respective CT techniques. The findings of this study proved X-ray CT to be a valuable tool for examining the effect of changing environmental conditions on the complex cambium structure of Corymbia hybrid seedlings.
Words of Wonder: The Cognitive and Semantic Dimension of the Literal and Figurative Denominators for wonder in Old English Sources
Authors: Minaya Gómez Francisco Javier 
Published: August 2023

Abstract
Based on the most recent research on emotion and, specifically, on contemporary aesthetic emotion theories, and combining methods from cognitive and historical linguistics, this paper aims at looking into the cognitive and semantic dimension of Old English literal and figurative denominators of wonder. Exploring how these terms are used in the Old English corpus, this paper highlights a recurrent use of literal emotion terms for wonder with varying semantics, and a wide array of figurative expressions that rely on the most common action tendencies and somatic profiles that are attributed to this emotion. This research stresses the rich variety that Old English authors had at their disposal when describing wonder-experiences and the many ways in which these authors described and narrated these emotional experiences, all of which, in extreme, reveals important information about the semantic dimension of these terms and identifiable patterns of conceptualisation for this emotion.
Banquo’s Daughters and the Lost #MeToo Macbeth, and Early Modern Alt-Media
Authors: Borlik Todd Andrew 
Published: August 2023

Abstract
This article investigates the disturbing accusation, first recorded in 1652, that Macbeth abducted and possibly raped a daughter of Banquo’s. Since Banquo himself was apparently fabricated by the Aberdonian chronicler Hector Boece in the 1520s to romanticize the Stuart dynasty’s origins, his daughter has no historical basis and tales of her grim fate likely represent a literary embellishment on the scene in which Malcolm reports Macbeth had confessed that kingship would awaken his insatiably lustful nature. These rumours, circulating at least by the early 1650s, would eventually culminate in an obscene prose romance entitled The Secret History of Mack-beth, first printed in 1708 shortly after the Acts of Union. Although the article entertains the tantalizing possibilities that Banquo’s daughter may have featured in the legendary uncut Macbeth, in deleted or censored additions to the play by Thomas Middleton (who created several female characters with the same name as Banquo’s daughter), or an unrealized adaptation planned by John Milton, the evidence proves too circumstantial. A safer assumption would be that the underground Macbeth was spawned by the radical press following Charles II’s coronation as King of Scotland at Scone in 1651. Nevertheless, this apocryphal legend illuminates some gaps in Shakespeare’s tragedy and affords an early example of how Shakespearean drama might be appropriated by an early modern forerunner of alt-media to feed a twisted sexual politics.
Edmund Spenser’s Sense of an Ending
Authors: Russell Jesse 
Published: August 2023

Abstract
Throughout his Faerie Queene, Edmund Spenser depicts himself as a “poet magus” who can peer behind the veil of Nature in order to discover a “secret teaching” of ethical and political virtue that he will impart to his readers. His readers are thus tasked with the chore of reforming the fallen world through the creation of an empire under Elizabeth. However, in “The Two Cantos of Mutabilitie,” Spenser seems to relinquish this vision. Indeed, Mutabilitie, on one level serves as a mirroring figure of Spenser’s own ambitions. Mutabilitie’s claims for the fragility and mutability of (temporal) existence are prefigured throughout The Faerie Queene, but in “The Two Cantos,” they take center stage. Spenser’s depiction of Nature’s triumph over Mutabilitie provides a lesson for Spenser himself, and he appears to reject his bombastic claims of knowledge as well as his projected imperial vision for a position of humble supplication before God, whose Providence is the ultimately the most powerful force in The Faerie Queene.
The Virus as Remedy: COVID-19 and the End of the Populist Meta-Crisis
Authors: Bitschnau Marco 
Published: August 2023

Abstract
Understood not only as a challenge to democracy but as a crisis, populism has received widespread attention in both media and academic circles for the better part of the past decade. Yet the outbreak of COVID-19 and its escalation into a pandemic eclipsed the fear of rising populism within weeks: With lockdowns imposed and civil liberties suspended, it lost its menacing character and became a mere background nuisance. This, I argue in this article, is the consequence of a discursive constellation in which there is only room for one dominant crisis – a meta-crisis as I call it – at a time. Populism filled this meta-crisis role for a long while, but the COVID-19 shock redirected society’s attention to a more pervasive and immediate threat. While this does not spell the end of populism, it still marks a notable shift in the relative importance we attribute to it.
Cardiovascular and Venous Thromboembolic Events After Hospital Discharge for COVID-19: A Prospective Single Center Study
Authors: Soudet S. , Basille D. , Carette H. , Mercier M. , Andrejak C. , Sevestre M.-A. 
Published: August 2023

Coronavirus disease 2019 (COVID-19) is associated with an increase in venous thrombotic and cardiovascular (CV) events has been reported during hospitalization. No systematic ultrasound follow-up to evaluate sequelae was ever that took place carried out prospectively associated with the evaluation of CV morbidity-mortality at 3 months post-discharge. Consecutive patients hospitalized for COVID-19 in the Amiens-Picardie University Hospital between 1st February and 31st August 2020 were included. The primary objective was the thrombosis incidence at 3 months after hospital discharge. Thrombosis was defined as either venous thromboembolism (VTE) or a CV event (CVE: myocardial infarction (MI), stroke or peripheral arterial disease). A secondary objective was to determine the risk factors for thrombotic events. We included 498 patients (279 men; 56%) of median age 66 (55-76) years. The primary composite outcome occurred in 27 patients (5.4%); 19 patients (3.8%) presented a CVE (stroke, n = 5; MI, n = 9; and peripheral arterial disease, n = 5). Two patients (0.8%) presented VTE. Six patients (1.2%) died. In multivariate analysis, a previous CVE was associated with thrombosis (OR 3.11; 95% CI 1.17-8.24). COVID-19 was significantly associated with thrombotic events post hospital discharge. Special attention should be given to CVE in the follow-up of patients with a previous thrombotic event.
Reinke’s Edema: Cold Steel Versus Radiofrequency Coblation
Authors: Lou Xudan , Lou Zhengcai 
Published: August 2023

Objective: This study compared the effects of radiofrequency (RF) coblation and cold steel (CS) surgery for the treatment of Reinke’s edema (RE). Methods: A retrospective analysis was conducted on 61 patients with RE, with 33 (54.1%) in the CS surgery group and 28 (45.9%) in the RF coblation group. The primary endpoints were the bilateral operation time and dyspnea severity, assessed preoperatively and at 1 and 3 months postoperatively. Secondary endpoints included subjective and objective vocal assessments, laryngovideostroboscopy (LVS) images, and Voice Handicap Index-10 (VHI-10) scores obtained before and at 1 and 3 months postoperatively. Results: The average bilateral operation time was significantly shorter in the RF coblation group (24.2 ± 3.9 min) compared to the CS group (38.4 ± 5.2 min) ( P = .041). All patients experienced a decrease in their Dyspnea Severity Index (DSI) scores postoperatively, with no significant differences observed between the two groups at any time point. However, improvements in the grade of hoarseness, roughness, and asthenia were significantly greater in the RF coblation group than in the CS group ( P < .001). There were no statistically significant differences in breathiness and strain between the two groups. The average VHI-10 score significantly decreased from preoperative values in both groups ( P < .001), with no significant differences observed between the two groups at any time point. Conclusions: The RF coblation procedure is a reliable and safe method for RE surgery, offering an effective treatment choice for RE.
Multi-objective multidisciplinary design optimization of liquid-propellant engines thrust chamber based on a surrogate model
Authors: Alimohammadi Hamid Reza , Aghaei-Togh Reza 
Published: August 2023

The design of liquid-propellant engines (LPEs) has several challenges in setting the performance parameters. Accordingly, optimizing the design of a thrust chamber is of considerable importance that has been considered in several research projects. Previous research has focused on multidisciplinary design optimization (MDO). However, despite these efforts, the main issues remain. The present paper proposes a multi-objective multidisciplinary design optimization based on an efficient adaptive surrogate model of the thrust chamber to address these issues. The proposed method introduces a practical multidisciplinary optimization method based on an adaptive surrogate model that uses the moving least squares methodology, CCM, sensitivity analysis, and the elite multi-objective genetic algorithm (NSGAII). Due to the high importance of specific impulse and thrust-to-weight ratio, these two functions were used as target functions and in the NSGAII framework, the Pareto frontier was drawn for them. The proposed method is applied to a thrust-chamber engine test case. The results show that the target performance of the engine is improved, the specific impulse value is increased by 3.4 s, and the thrust-to-weight ratio is increased by 4%. These values represent significant advances in LPE engine design. The results obtained in this study indicate the potential of the proposed method in solving large-scale thrust-chamber design optimization problems.
How does ethical leadership influence nurses’ job performance? Learning goal orientation as a mediator and co-worker support as a moderator
Authors: Zhang Chunyu , Xiao Qijie , Liang Xiaoyan , Klarin Anton , Liu Liping 
Published: August 2023

Background Ethical nurse leaders play a pivotal role in helping their nurse employees deliver high-quality healthcare services. However, we still lack a comprehensive understanding of the mediating and moderating mechanisms by which ethical leadership improves job performance. Purpose This study aims to investigate: (1) whether ethical leadership would enhance nurses’ job performance; (2) whether learning goal orientation acts as a mediator; and (3) whether co-worker support operates as a moderator. Participants and research context We collected two-wave data from 218 nurses working in hospitals located in Jiangsu, China. Research design A time-lagged study based on an online survey design was utilized for data collection between September 2022 and January 2023. PROCESS Model 5 was employed to test the research hypotheses. Ethical considerations We obtained ethics approval from the University Ethics Committee. The nursing participants were assured that their survey responses were completely anonymous. Results and discussion Ethical leadership is not significantly correlated with job performance. However, ethical leadership has an indirect impact on nurses’ job performance through the mediator (learning goal orientation). Moreover, co-worker support moderates the relationship between ethical leadership and job performance. Conclusion The conceptual model provides us with a fine-grained understanding of the relationship between ethical leadership and nurses’ job performance. We highlight the mediating role of learning goal orientation and the moderating role of co-worker support. We suggest that healthcare organizations should devote more efforts to promoting ethical leadership, co-worker support, and learning goal orientation.
Two cases of nursing older nursing home residents during COVID-19
Authors: Jaarsma Pier , Gelhaus Petra , Eklund Saksberg My 
Published: August 2023

Introduction Two ethical challenges of nursing home nurses during the COVID-19 pandemic in Sweden are discussed in this paper. Background Historically, the nurse’s primary concern is for the person who is ill, which is the core of nurses’ moral responsibility and identity. In Sweden, person-centered care is generally deemed important in nursing older nursing home residents. Objective To chart moral responsibilities of nursing home nurses in two cases involving older residents during the COVID-19 pandemic in Sweden. Methods We used Margaret Urban Walker’s framework for moral responsibilities and the International Council of Nurses (ICN) code of ethics for nurses (2021) for our normative analysis. Ethical considerations Written and verbal consent was obtained before the interviews, and information was given that participation was entirely voluntary and possible to cancel at any time before the work was published. The Swedish Ethical Review Agency gave an advisory opinion stating that there were no ethical objections to this research project (Dnr. 2020-05649). Findings Case #1: a palliative older nursing home resident who was coercively tested for COVID-19, and case #2: a COVID-19–infected resident with dementia who was isolated using sedation. The decision that was finally made in the respective case was analyzed in the light of either consequentialist/utilitarian or non-consequentialist/deontological reasons. Discussion Empowerment of nurses as moral agents is required for the application of practical wisdom in the balancing of different care relationships (responsibilities), moral identities (professional virtues), and competing moral values. This requires resources and opens possibilities for profound ethical reflection in nursing education and at work. Conclusion During the COVID-19 pandemic, the moral and professional responsibility of nursing home nurses to deliver person-centered care was sometimes problematically abandoned in favor of a more utilitarian manner of ethical decision-making.
Outpatient Utilization of the RAM Cannula for Nasal Noninvasive Ventilation in Children
Authors: Truitt Brittany A , Kallam Erin F , Price Eric W , Shah Amit S , Simon Dawn M , Kasi Ajay S 
Published: August 2023

Background: The RAM cannula® consists of nasal prongs that can be used to administer oxygen, continuous, and bilevel positive airway pressure therapies. Studies have reported the efficacy and utility of the RAM cannula in inpatients requiring noninvasive ventilation (NIV); however, there is limited literature on the use of the RAM cannula to provide NIV in the outpatient setting. Objectives: This study aimed to describe the clinical features and outcomes of children who used NIV via RAM cannula in the outpatient setting. Design: Retrospective review. Methods: We conducted a retrospective review of children treated with outpatient NIV via RAM cannula at our institution between January 2010 and March 2023. The analyzed data included age, diagnoses, indications for NIV, duration of RAM cannula use, complications, and outcomes at 6 months. Results: We identified 20 patients who used outpatient NIV via RAM cannula during the study period. The median age at initiation of NIV via RAM cannula was 5.8 months (IQR 2.4-9.9 months). Indications for NIV included sleep-related hypoventilation (15%), restrictive lung disease (25%), obstructive sleep apnea (45%), and chronic respiratory failure (50%), with 6 patients having ⩾2 indications for NIV. RAM cannula was utilized for inability to tolerate conventional NIV interfaces (80%), to alleviate dyspnea (60%), and to avoid tracheostomy (55%). Patients used NIV via RAM cannula for a median duration of 7.7 months (IQR 3.7-20.6 months). Patient outcomes included ongoing usage of RAM cannula (55%), changing to conventional NIV interfaces (15%) or oxygen (10%), weaning off respiratory support (5%), and death (15%). There were no complications related to using the RAM cannula. Conclusion: Our study demonstrates the utility of outpatient NIV via RAM cannula in children with a variety of diagnoses until clinical improvement or tolerance of conventional interfaces, and for avoidance of tracheostomy.