bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cisheteronormativity and its influence on the psychosocial experience of LGBTQ+ people with cancer: A qualitative systematic review
Authors: Franco‐Rocha Oscar Y. , Wheldon Christopher W. , Osier Nico , Lett Elle , Kesler Shelli R. , Henneghan Ashley M. , Suárez‐Baquero Daniel Felipe Martín 
Published: April 2023

AbstractObjectiveCisheteronormativity refers to the relationship of heterosexual and cisgender privilege stemming from patriarchy. Although studies have shown that cisheteronormativity can impact health outcomes for lesbian, gay, bisexual, transgender, queer and other sexual, gender diverse, and gender nonconforming (LGBTQ+) people, the specific impact on cancer care has not been described. We synthesized the qualitative evidence on how cisheteronormativity impacts the psychosocial experience of LGBTQ+ people with cancer.MethodsWe conducted a historic search in the CINAHL, LGBT+ Health, PsycInfo, and PubMed databases. Qualitative studies that described the psychosocial experience of LGBTQ+ people with cancer were included. After appraising the quality of the publications, 11 articles were included. Then, we conducted inductive nominal coding, taxonomic analysis, and thematic synthesis.ResultsTwo main themes emerged, (1) Cisheteronormativity as a social determinant of health, and (2) Cancer, sexual orientation, and gender: Associations and introjections. The themes comprise four categories and 13 subcategories that describe the impact of cisheteronormativity on the cancer experience of LGBTQ+ people.ConclusionCisheteronormativity within the healthcare system impacts the psychosocial experience of LGBTQ+ people with cancer. Understanding how these gender biases, norms, and social expectations impact the cancer experience is necessary to transform social norms and promote health equity.
Enhancing the •OH generation of atmospheric pressure plasma jets by mixing water aerosols at downstream region
Authors: Lin Tsung‐Rong , Hsieh Yu‐Shen , Zhang Rui‐Zhe , Cheng Yun‐Chien 
Published: April 2023

AbstractWe established a downstream plasma–aerosol mixing system to increase the generation of •OH in an atmospheric pressure plasma jet (APPJ). Four downstream plasma–aerosol mixers were designed, and flow rates of water aerosol were adjusted. Methods to increase •OH in APPJ include increasing ambient humidity, adding water to working gas, treating on wet surfaces, or using water electro‐spray, but have disadvantages. Our method can increase the reaction area between water and plasma and prevent water from quenching the plasma. The ICCD, TA test, and sterilization results revealed that mixing aerosols in the downstream region effectively increased the amount of •OH generation and enhanced sterilization effect. The cone swirl mixer and two‐way swirl mixer generated the strongest and widest •OH emission region, respectively.
Damage of SARS‐CoV‐2 spike protein by atomic oxygen of cold atmospheric plasma: A molecular dynamics study
Authors: Yang Zihao , Xiao Ao , Liu Dawei , Shi Qi , Li Yan 
Published: April 2023

AbstractRecently, the cold atmospheric plasma (CAP) has demonstrated a satisfactory ability to inactivate severe acute respiratory syndrome CoV‐2 (SARS‐CoV‐2), but the microscopic inactivation mechanism is still unclear. This paper takes the interaction process between O atoms generated by plasma and the spike protein of coronavirus as the research object. It uses the reaction molecular dynamics simulation method to study the reaction mechanism of different numbers of O atoms and the spike protein molecules. The results show that the O atom triggers a chain reaction by taking away hydrogen atoms in the spike protein molecule, destroying the molecular structure of the spike protein and making it inactive. The severity of the reaction and the destruction of the spike protein molecule also increases with increasing O atom numbers.
Genetically encoded crosslinkers to address protein–protein interactions
Authors: Aydin Yasmin , Coin Irene 
Published: April 2023

AbstractNoncanonical amino acids (ncAAs) for photo‐ and chemical crosslinking are powerful biochemical tools for studying and manipulating interactions between proteins both in vitro and in intact cells. Since the first crosslinking ncAAs were genetically encoded about 20 years ago, the technology has now ripened beyond the proof‐of‐principle demonstrations and is contributing to the study of relevant biological questions in the frame of modern integrative approaches. Here, we provide an overview of available photo‐activatable ncAAs for photo‐crosslinking and electrophilic ncAAs for genetically encoded chemical crosslinking (GECX), with a major focus on the most recent entries such as ncAAs for SuFEx click chemistry and photo‐activatable ncAAs for chemical crosslinking. We present recent examples of the application of genetically encoded crosslinkers to capture protein–protein interactions and identify interaction partners in live cells, to investigate molecular mechanisms of protein function, to stabilize protein complexes for structural studies, to derive structural information about protein complexes from the physiological cell environment, up to perspective applications of GECX‐ncAAs for the development of covalent drugs.
Characterizations of a Spacetime of Quasi‐Constant Sectional Curvature and F(R)$\mathcal {F}(\mathcal {R})$‐Gravity
Authors: De Uday Chand , De Krishnendu , Zengin Fusun Ozen , Demirbag Sezgin Altay 
Published: April 2023

AbstractThe main aim of this article is to investigate a spacetime of quasi‐constant sectional curvature. At first, the existence of such a spacetime is established by several examples. We have shown that a spacetime of quasi‐constant sectional curvature agrees with the present state of the universe and it represents a Robertson Walker spacetime. Moreover, if the spacetime is Ricci semi‐symmetric or Ricci symmetric, then either the spacetime represents a spacetime of constant sectional curvature, or the spacetime represents phantom era. Also, we prove that a Ricci symmetric spacetime of quasi‐constant sectional curvature represents a static spacetime and the spacetime under consideration is of Petrov type I, D or O. Finally, we concentrate on a quasi‐constant sectional curvature spacetime solution in ‐gravity. As a result, various energy conditions are studied and analyzed our obtained outcomes in terms of a ‐gravity model.
Complexity‐Free Anisotropic Solution of Buchdahl's Model and Energy Exchange Between Relativistic Fluids by Extended Gravitational Decoupling
Authors: Maurya S. K. , Singh Ksh. Newton , Govender Megan , Ray Saibal 
Published: April 2023

AbstractIn this work, we present an anisotropic generalization of the Buchdahl static stellar model by implementing the method of extended gravitational decoupling and further requirement of vanishing complexity (Herrera, Phys Rev D 97:044010,2018). Starting off with a general spherically symmetric static metric with two unknown gravitational potentials, we impose the condition of vanishing complexity which then reduces the problem to a single‐generating metric function [Contreras and Stuchlik, Eur. Phys. J. C (2022) 82:706]. The Buchdahl ansatz is then employed to obtain the complete gravitational behavior of the isotropic seed solution. The method of extended gravitational decoupling is thereafter utilized to obtain an anisotropic counterpart of the Buchdahl perfect gravitating sphere. We subject our solution to rigorous physical tests to ensure that it serves as a viable candidate for compact objects such as neutron stars as well as pulsars. We show that the decoupling parameter plays a crucial role in determining the stability and regularity of several key physical features of the entire stellar model. A novel finding of our investigation is the energy exchange between the seed solution and the secondary source which we show is sensitive to the decoupling parameter. In addition, it has also been shown that the direction of energy flow depends on the radial distance of the shell from the center of the stellar configuration.
Biased computation of probability of target attainment for antimicrobial drugs
Authors: Toutain Pierre‐Louis , Gandia Peggy , Pelligand Ludovic , Ferran Aude A. , Lees Peter , Bousquet‐Mélou Alain , Concordet Didier 
Published: April 2023

AbstractThe medical literature is replete with articles in which there is confusion between “free concentration” and “unbound fraction” (fu), which is the ratio of free to total plasma concentration. The lack of clarity in distinguishing between these two terms has led to biased computations, erroneous interpretations, and misleading recommendations. The problems are highlighted in this paper, taking the example of calculation of Probability of Target Attainment (PTA). This metric is used to propose pharmacokinetic/pharmacodynamic (PK/PD) breakpoints required for the interpretation of Antimicrobial Susceptibility Testing. Based on Monte Carlo simulations of the PK/PD index, area under the unbound concentration time curve/minimum inhibitory concentration (fAUC/MIC), computation of PTA from total plasma concentrations scaled by fu ineluctably leads to biased estimates. The bias is greater if the variability associated with fu is added, instead of removing it during this scaling. The explanation for the bias is that total plasma drug concentrations are intrinsically more variable than the corresponding free concentrations. This is due to the variability of antimicrobial binding for total, but not for free plasma concentrations. In consequence, the greater variability always leads to underestimation of the PK/PD cutoff (i.e., the critical MIC that is guaranteed for a given percentile of the population). A further consequence is an increase in calculated dosage required to attain the targeted quantile. This erroneous approach, of using free antimicrobial drug fraction, is not limited to the derivation of PK/PD cutoff, but may also have consequences for antimicrobials drug safety in clinical patients.
Prognosis of pulmonary arterial hypertension patients with pericardial effusion before and after initiation of parenteral prostacyclin therapy
Authors: Abu‐Rmaileh Muhammad , Mirza Omer , Patel Chandni , Shah Trushil , Hardin Elizabeth A. , Bartolome Sonja D. , Chin Kelly M. 
Published: April 2023

AbstractFew studies have evaluated the effects of pulmonary arterial hypertension therapies on pericardial effusion. We evaluated hemodynamics, echocardiograms, and outcomes for 119 parenteral prostanoid‐treated patients. We discovered an increased frequency of pericardial effusions posttreatment, and that a moderate‐large pericardial effusion at initiation, but not at 1st follow‐up, was significantly associated with mortality.
Ensemble‐based estimates of the impact of potential observations
Authors: Griewank Philipp J. , Weissmann Martin , Necker Tobias , Nomokonova Tatiana , Löhnert Ulrich 
Published: April 2023

AbstractIn order to conduct observation‐network design experiments for a forecast system, methods are needed to estimate the benefit of potential observations. Ideally, these methods are flexible enough to accommodate multiple observation types and forecast lead times while being computationally fast enough to evaluate many potential observational network layouts. For ensemble forecasts, this can be achieved by assuming that analysis and forecast errors are represented by the respective ensemble variance and by assuming a linear ensemble sensitivity between the background state and a forecast quantity of choice. These assumptions enable estimating how much the forecast error of a forecast quantity would be reduced for an arbitrary combination of observation locations and types without the need to run additional forecasts. An aspect that has received little attention is that to apply these variance‐reduction estimates to a specific ensemble‐forecast system consistently, the system's localization needs to be taken into account. We introduce and compare three methods to take localization into account when estimating the benefit of potential observations. One method requires explicitly inverting the background ensemble covariance matrix, one method avoids the inversion but needs to be provided with estimates of signal propagation over time, and the third method requires both the inversion and the signal propagation estimate. We introduce a simple linear‐advection toy model to perform various observing‐system simulation experiments to test the three methods with point and indirect observations. Our results indicate that the methods requiring signal propagation to be provided are best suited to short lead times, whereas the remaining method is more accurate if signal propagation is not known well; for example, for longer lead times.
Reaction mechanism between Gen (n = 2–5) clusters and single water molecule based on density functional theory
Authors: Tang Leilei , Shi Shunping , Song Yong , Duan Zhanjiang , Jiang Jing , Diao Kai , Hu Jiabao , Chen Deliang 
Published: April 2023

AbstractThe ground state structures of Gen (n = 2–5) clusters and their adsorption energy values with single water molecule were calculated using density functional theory. We also investigated the reaction pathways between Gen (n = 2–5) clusters and single water molecule. Based on molecular orbital and natural population analysis (NPA) figures, it was found that the O atom in H2O binds to the Gen (n = 2–5) clusters to form GenO (n = 2–5) and releases hydrogen. Notably, the Ge2 cluster exhibited the most efficient interaction with single water molecule based on the comparison of the energy values during the reaction of hydrogen generation. Furthermore, NPA and density of states analyses indicate that the Ge atoms in the products did not reach their highest oxidation state, suggesting that GenO (n = 2–5) may continue to react with more water molecules to generate hydrogen. Our results provide a deeper understanding of the chemical reaction properties.
3D‐Printed Micro/Nano‐Scaled Mechanical Metamaterials: Fundamentals, Technologies, Progress, Applications, and Challenges
Authors: Su Ruyue , Chen Jingyi , Zhang Xueqin , Wang Wenqing , Li Ying , He Rujie , Fang Daining 
Published: April 2023

AbstractMicro/nano‐scaled mechanical metamaterials have attracted extensive attention in various fields attributed to their superior properties benefiting from their rationally designed micro/nano‐structures. As one of the most advanced technologies in the 21st century, additive manufacturing (3D printing) opens an easier and faster path for fabricating micro/nano‐scaled mechanical metamaterials with complex structures. Here, the size effect of metamaterials at micro/nano scales is introduced first. Then, the additive manufacturing technologies to fabricate mechanical metamaterials at micro/nano scales are introduced. The latest research progress on micro/nano‐scaled mechanical metamaterials is also reviewed according to the type of materials. In addition, the structural and functional applications of micro/nano‐scaled mechanical metamaterials are further summarized. Finally, the challenges, including advanced 3D printing technologies, novel material development, and innovative structural design, for micro/nano‐scaled mechanical metamaterials are discussed, and future perspectives are provided. The review aims to provide insight into the research and development of 3D‐printed micro/nano‐scaled mechanical metamaterials.
Synergistic Effect of N‐NiMoO4/Ni Heterogeneous Interface with Oxygen Vacancies in N‐NiMoO4/Ni/CNTs for Superior Overall Water Splitting
Authors: Li Guang‐Lan , Qiao Xiang‐Yue , Miao Ying‐Ying , Wang Tian‐Yu , Deng Fei 
Published: April 2023

AbstractThe exploring of economical, high‐efficiency, and stable bifunctional catalysts for hydrogen evolution and oxygen evolution reactions (HER/OER) is highly imperative for the development of electrolytic water. Herein, a 3D cross‐linked carbon nanotube supported oxygen vacancy (Vo)‐rich N‐NiMoO4/Ni heterostructure bifunctional water splitting catalyst (N‐NiMoO4/Ni/CNTs) is synthesized by hydrothermal‐H2 calcination method. Physical characterization confirms that Vo‐rich N‐NiMoO4/Ni nanoparticles with an average size of ≈19 nm are secondary aggregated on CNTs that form a hierarchical porous structure. The formation of Ni and NiMoO4 heterojunctions modify the electronic structure of N‐NiMoO4/Ni/CNTs. Benefiting from these properties, N‐NiMoO4/Ni/CNTs drives an impressive HER overpotential of only 46 mV and OER overpotential of 330 mV at 10 mA cm−2, which also shows exceptional cycling stability, respectively. Furthermore, the as‐assembled N‐NiMoO4/Ni/CNTs||N‐NiMoO4/Ni/CNTs electrolyzer reaches a cell voltage of 1.64 V at 10 mA cm−2 in alkaline solution. Operando Raman analysis reveals that surface reconstruction is essential for the improved catalytic activity. Density functional theory (DFT) calculations further demonstrate that the enhanced HER/OER performance should be attributed to the synergistic effect of Vo and heteostructure that improve the conductivity of N‐NiMoO4/Ni/CNTs and facilitatethe desorption of reaction intermediates.
Highly Stable and Efficient Oxygen Evolution Electrocatalyst Based on Co Oxides Decorated with Ultrafine Ru Nanoclusters
Authors: Du Jian , Chen Dexin , Ding Yunxuan , Wang Linqin , Li Fei , Sun Licheng 
Published: April 2023

AbstractExploring highly active and durable electrocatalysts for oxygen evolution reaction (OER) is significant to achieve efficient anion exchange membrane (AEM) water electrolysis. Herein, hollow Co‐based N‐doped porous carbon spheres decorated with ultrafine Ru nanoclusters (HS‐RuCo/NC) are reported as efficient OER electrocatalysts via the pyrolysis of carboxylate‐terminated polystyrene‐templated bimetallic zeolite imidazolate frameworks accommodating Ru (III) ions. The unique hollow structure with hierarchically porous characteristics contributes to the electrolyte penetration for fast mass transport and the exposure of more metal sites. Theoretical and experimental studies reveal the synergistic effect between the in situ formed RuO2 and Co3O4 as another critical factor for the high OER performance, where the coupling of RuO2 with Co3O4 can optimize the electronic configuration of RuO2/Co3O4 heterostructure and decrease the energy barrier during OER. Meanwhile, the presence of Co3O4 can efficiently suppress the over‐oxidation of RuO2, endowing the catalysts with high stability. As expected, when the resultant HS‐RuCo/NC was integrated into an AEM water electrolyzer, the obtained electrolyzer exhibits a cell voltage of 2.07 V to launch the current density of 1 A cm−2 and excellent long‐term stability at 500 mA cm−2 under room temperature in alkaline solution, outperforming the commercial RuO2‐based AEM water electrolyzer (2.19 V).
P and Se Binary Vacancies and Heterostructures Modulated MoP/MoSe2 Electrocatalysts for Improving Hydrogen Evolution and Coupling Electricity Generation
Authors: Yan Wensi , Ma Hui , Zhao Xueting , Zhang You , Vishniakov Paul , Wang Xin , Zhong Xiaohong , Hong Zhe , Maximov Maxim Yu. , Song Li , Peng Shengjie , Li Lei 
Published: April 2023

AbstractIt is not enough to develop an ideal hydrogen evolution reaction (HER) electrocatalysts by single strategy. Here, the HER performances are significantly improved by the combined strategies of P and Se binary vacancies and heterostructure engineering, which is rarely explored and remain unclear. As a result, the overpotentials of MoP/MoSe2‐H heterostructures rich in P and Se binary vacancies are 47 and 110 mV at 10 mA cm−2 in 1 m KOH and 0.5 m H2SO4 electrolytes, respectively. Especially, in 1 m KOH, the overpotential of MoP/MoSe2‐H is very close to commercial Pt/C at the beginning and even better than Pt/C when current density is over 70 mA cm−2. The strong interactions between MoSe2 and MoP facilitate electrons transfer from P to Se. Thus, MoP/MoSe2‐H possesses more electrochemically active sites and faster charge transfer capability, which are all in favor of high HER activities. Additionally, Zn‐H2O battery with MoP/MoSe2‐H as cathode is fabricated for simultaneous generation of hydrogen and electricity, which displays the maximum power density of up to 28.1 mW cm−2 and stable discharging performance for 125 h. Overall, this work validates a vigorous strategy and provides guidance for the development of efficient HER electrocatalysts.
Tailoring the Angular Mismatch in MoS2 Homobilayers through Deformation Fields
Authors: Burns Kory , Tan Anne Marie Z. , Hachtel Jordan A. , Aditya Anikeya , Baradwaj Nitish , Mishra Ankit , Linker Thomas , Nakano Aiichiro , Kalia Rajiv , Lang Eric J. , Schoell Ryan , Hennig Richard G. , Hattar Khalid , Aitkaliyeva Assel 
Published: April 2023

AbstractUltrathin MoS2 has shown remarkable characteristics at the atomic scale with an immutable disorder to weak external stimuli. Ion beam modification unlocks the potential to selectively tune the size, concentration, and morphology of defects produced at the site of impact in 2D materials. Combining experiments, first‐principles calculations, atomistic simulations, and transfer learning, it is shown that irradiation‐induced defects can induce a rotation‐dependent moiré pattern in vertically stacked homobilayers of MoS2 by deforming the atomically thin material and exciting surface acoustic waves (SAWs). Additionally, the direct correlation between stress and lattice disorder by probing the intrinsic defects and atomic environments are demonstrated. The method introduced in this paper sheds light on how engineering defects in the lattice can be used to tailor the angular mismatch in van der Waals (vdW) solids.
How Size and Strain Effect Synergistically Improve Electrocatalytic Activity: A Systematic Investigation Based on PtCoCu Alloy Nanocrystals
Authors: Zhang Wenjing , Li Jing , Wei Zidong 
Published: April 2023

AbstractTo reveal how the size effect and strain effect synergistically regulate the mass activity (MA) and specific activity (SA) of Pt alloy nanocrystal catalysts in oxygen reduction reaction (ORR), remains to be difficult due to the highly entangled factors. In this work, six ternary PtCoCu catalysts with sequentially changed composition, size, and compression strain are prepared. It is found that the smaller the alloy particles, the higher the electrochemical active surface area (ECSA) and MA values, that is, the particle size plays a decisive role in the size of the ECSA and MA. While, along alloy size decrease, the intrinsic activity SA first increases, then remains unchanged, and finally rapidly increases again. This detailed analysis shows that for the alloys above 4 nm, it is the surface coordination number that decides the SA, while for those below 4 nm, it is the well‐regulated compression strain that determines the SA. Particularly, Pt47Co26Cu27 demonstrates the MA of 1.19 A mgPt−1 and SA of 1.48 mA cm−2, being 7.9 and 6.4 times those of commercial Pt/C respectively, representing an especially superior ORR catalyst.