bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity and reliability of the COVID‐19 Anxiety Syndrome Scale in Canadian dentists
Authors: Seth Rachita , Madathil Sreenath A. , Siqueira Walter L. , McNally Mary , Quiñonez Carlos R. , Glogauer Michael , Allison Paul J. 
Published: June 2023

AbstractBackgroundThe COVID‐19 pandemic has resulted in a high level of mental health problems for the population worldwide including healthcare workers. Several studies have assessed these using measurements for anxiety for general populations. The COVID‐19 Anxiety Syndrome Scale (C‐19ASS) is a self‐report measure developed to assess maladaptive forms of coping with COVID‐19 (avoidance, threat monitoring and worry) among a general adult population in the United States. We used it in a prospective cohort study of COVID‐19 incidence rates in practising Canadian dentists. We therefore need to ensure that it is valid for dentists in French and English languages. This study aimed to evaluate the validity of the C‐19ASS in that population.MethodsCross‐sectional data from the January 2021 monthly follow‐up in our prospective cohort study were used. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were performed.ResultsThe results of EFA revealed a 2‐factor structure solution that explained 47% of the total variance. The CFA showed a good model fit on the data in both English and French languages. The Cronbach's alpha indicated acceptable levels of reliability. Furthermore, the C‐19ASS showed excellent divergent validity from the Generalized Anxiety Disorder‐7 (GAD‐7) scale.ConclusionsThe C‐19ASS is valid and reliable instrument to measure COVID‐19‐related anxiety in English and French among Canadian dentists.Practical implicationsThis validated measure will contribute to understanding of the mental health impact of the pandemic on dentists in Canada and enable the dental regulatory authorities and organizations to intervene to help dentists.
Atomic‐level investigation on significance of photoreduced Pt nanoparticles over g‐C3N4/bimetallic oxide composites
Authors: Shenoy Sulakshana , Chuaicham Chitiphon , Sekar Karthikeyan , Sasaki Keiko 
Published: June 2023

AbstractDesigning an effective photocatalyst for solar‐to‐chemical fuel conversion presents significant challenges. Herein, g‐C3N4 nanotubes/CuCo2O4 (CN‐NT‐CCO) composites decorated with platinum nanoparticles (Pt NPs) were successfully synthesized by chemical and photochemical reductions. The size distribution and location of Pt NPs on the surface of CN‐NT‐CCO composites were directly observed by TEM. Extended X‐ray absorption fine structure (EXAFS) spectra of Pt L3‐edge for the above composite confirmed establishment of Pt−N bonds at an atomic distance of 2.09 Å in the photoreduced Pt‐bearing composite, which was shorter than in chemically reduced Pt‐bearing composites. This proved the stronger interaction of photoreduced Pt NPs with the CN‐NT‐CCO composite than chemical reduced one. The H2 evolution performance of the photoreduced (PR) Pt@CN‐NT‐CCO (2079 μmol h−1 g−1) was greater than that of the chemically reduced (CR) Pt@CN‐NT‐CCO composite (1481 μmol h−1 g−1). The abundance of catalytically active sites and transfer of electrons from CN‐NT to the Pt NPs to participate in the hydrogen evolution are the primary reasons for the improved performance. Furthermore, electrochemical investigations and band edge locations validated the presence of a Z‐scheme heterojunction at the Pt@CN‐NT‐CCO interface. This work offers unique perspectives on the structure and interface design at the atomic level to fabricate high‐performance heterojunction photocatalysts.
Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de‐palmitoylation
Authors: Shi Zhehao , Li Zhiming , Jin Bin , Ye Wen , Wang Luhui , Zhang Sina , Zheng Jiuyi , Lin Zixia , Chen Bo , Liu Fangting , Zhang Baofu , Ding Xiwei , Yang Zhen , Shan Yunfeng , Yu Zhengping , Wang Yi , Chen Jicai , Chen Qiang , Roberts Lewis R. , Chen Gang 
Published: June 2023

AbstractBackgroundFerroptosis is an important iron‐dependent form of cell death in hepatocellular carcinoma (HCC). Sorafenib, a potent ferroptosis inducer, is used to treat advanced HCC but its efficacy is limited by the development of drug resistance.MethodsThe effects of DUXAP8 expression on HCC progression were evaluated by TCGA database, Kaplan‐Meier analysis, and in situ hybridization analysis. Sorafenib resistant HCC cell lines were modeled in vitro to study the regulation of DUXAP8 on ferroptosis in HCC induced by sorafenib. We used RNA pull‐down, immunofluorescence assays, acyl‐biotinyl exchange assay and mass spectrometry analysis to assess the molecular mechanism of ferroptosis regulation by DUXAP8. Syngeneic subcutaneous and orthotopic CDX models were used to assess whether DUXAP8 inhibition improves HCC in vivo.ResultsLncRNA DUXAP8, which is highly expressed in liver cancer and associated with poor prognosis, contributes to sorafenib resistance through suppression of ferroptosis. In vitro tests revealed that DUXAP8 reduced the sensitivity of HCC to sorafenib‐induced ferroptosis by acting on SLC7A11, a subunit of the amino acid antiporter system xc‐. DUXAP8 facilitates SLC7A11 palmitoylation and impedes its lysosomal degradation, thereby enhancing SLC7A11 action and suppressing ferroptosis. RNA pull‐down and immunofluorescence assays confirmed that DUXAP8 decreased membrane translocation and promoted sorting of de‐palmitoylated SLC7A11 to lysosomes by binding of DUXAP8 to SLC7A11. In addition, mass spectrometric analysis found that the Cys414 residue of SLC7A11 might be the predominant mutant site responsible for molecular masking of SLC7A11 lysosomal sorting. Further, the antitumor effect of DUXAP8 knockdown was verified in orthotopic and subcutaneous CDX models.ConclusionsOur findings suggest that a novel translational strategy combining sorafenib with DUXAP8 silencing to overcome drug resistance may improve treatment efficacy in patients with advanced HCC.
Transitioning intravenous epoprostenol to oral selexipag in idiopathic pulmonary arterial hypertension: a case report
Authors: Alexandre André , Furtado Inês , Carvalho Luísa , Gonçalves Fabienne , Melo Alzira , Alves Joana , Santos Mário , Reis Abílio 
Published: June 2023

AbstractIntravenous (i.v.) prostacyclin is the cornerstone treatment in high‐risk pulmonary arterial hypertension (PAH) patients. Selexipag is an orally available prostacyclin receptor agonist. Limited data are available regarding the feasibility of transitioning from i.v. epoprostenol to selexipag. A 50‐year‐old woman with idiopathic PAH was diagnosed in a World Health Organization (WHO) Functional Class (FC) IV. She improved with upfront triple combination therapy, including i.v. epoprostenol. Over 2 years of follow‐up, the patient remained at low risk and expressed strong preference towards oral therapies. After careful risk–benefit clinical consideration, she was transitioned from i.v. epoprostenol to selexipag. Selexipag was started at dosage of 200 μg twice daily (b.i.d.) and titrated up to 1600 μg b.i.d. over 8 weeks (up‐titration of 200 μg b.i.d. every week). Simultaneously, i.v. epoprostenol was down‐titrated 3.0 ng/kg/min every week from a dosage of 27.5 ng/kg/min. The transition occurred under strict medical surveillance and was well tolerated. One year after discontinuation of epoprostenol, the patient remains in WHO FC I and has no signs of clinical deterioration. Although not generalizable to most PAH patients, this case highlights that a carefully planned transition from epoprostenol to selexipag is feasible in selected low‐risk patients within a shared medical decision‐making framework.
Synthesis, Characterization, and Singlet Oxygen Sensitization by Antimony (III/V) Corrole Complexes
Authors: Mondal Sruti , Pain Tanmoy , Villa Marco , Angeloni Sara , Tarai Arup , Ceroni Paola , Kar Sanjib 
Published: June 2023

AbstractThe synthesis, structural, spectroscopic characterization, and DFT/TD‐DFT calculations of antimony corroles are reported herein. The studied complexes can be described as [(Corr)SbIII] and [(Corr)(oxo)SbV]2, where Corr is the trianion of corrole. All these complexes are diamagnetic in nature as is evident from sharp peaks with normal chemical shifts in the 1H NMR spectra. Single crystal XRD analysis reveals that the antimony(V) corrole complex is the bis‐μ‐oxo‐bridged dinuclear antimony(V). Both the tetra and hexa‐coordinated [(Corr)SbIII] and [(Corr)(oxo)SbV]2 antimony complexes adopt domed‐structure with weak d‐π electron coupling. The Sb−O bond distances in the co‐facial dimer of [(Corr)(oxo)SbV]2 are 1.9802(16) Å (DFT: 2.0141 Å) (for Sb1−O1), and 1.9639(17) Å (DFT: 1.9957 Å) (for Sb2−O2) respectively. We observed that even though iodosobenzene is frequently used to oxidize [(Corr)SbIII] species, the oxidation of [(Corr)SbIII] is indeed very facile in nature and it even occurred in the air‐equilibrated CHCl3 solution while storing for few days. Excitation of these antimony (III/V) corrole complexes in DCM/MeOH (1 : 1) at 77 K results in red emission with maxima at 640–720 nm. The singlet oxygen production of [(Corr)(oxo)SbV]2 has a quantum yield of 69 % and is two times higher than the analogous [(Corr)SbIII] derivatives.
Study on mixing characteristics of multichamber static mixer
Authors: Shi Hongwei , Liu Ziqiang 
Published: June 2023

AbstractThis study presents a specialized mixer design for gas burners aimed at improving the efficiency of phase mixing while minimizing system resistance and energy consumption. The proposed design utilizes a multi‐cavity mixer employing both radial and axial mixing techniques, eliminating the need for additional power supply. Full premixed combustion of small gas‐fired industrial boiler has the function of “inhibiting” NOx emission from the source, and good mixing of fuel and combustion supporting air in the early stage is the primary prerequisite for realizing full premixed combustion denitration. In this article, a radial multichamber static mixer is designed following the characteristics of full premixed mixing in gas‐fired industrial boilers. The results demonstrate that the maximum pressure drop of the static mixer is 806 Pa; for gas and air branch pipes, the resistance coefficient f decreases rapidly with the increase in Reynolds number; when Re ≥ 1.2 × 103, the resistance coefficient in the air branch pipe decreases slowly; when Re ≥ 4.5 × 103, the resistance coefficient of gas branch pipe decreases slowly. Additionally, the maximum calculation error of symmetrical gas branch pipe is 9.1%. The static mixer's inlet exhibits a converted velocity of 24 m/s, and the outlet demonstrates an airflow velocity of 23.2 m/s. As a result, a kinetic energy loss of 6.5% is observed. The static mixing chamber makes the airflow rotate and causes different gases to shear and mix. The mixing channel has the function of correcting the airflow deviation, especially for the sudden expansion section. Generally, the two gases can be mixed evenly at the outlet of the mixer. The standard k‐e model and realizable k‐e model are employed to simulate the sudden expansion channel, and indicate that the standard k‐e has a wider range of influence. Further investigation is recommended to better comprehend and optimize this particular area of influence.
Healthy beverage index could decrease odds of metabolic syndrome: A cross‐sectional study
Authors: Nouri Mehran , Shateri Zainab , Rezaei Mahshid , Zangene Ali , Homayounfar Reza , Keshani Parisa 
Published: June 2023

AbstractSome studies indicated that sugar‐sweetened beverages (SSBs) were related to MetS risk, and others found no relationship between MetS and SSBs. Therefore, the present study aimed to investigate the relationship between healthy beverage index (HBI) and MetS in Iranian adults. This cross‐sectional study was performed on baseline data FASA cohort. Out of 10,127 participants in the FASA cohort study, 8838 participants were included in this study. The National Cholesterol Education Program's Adult Treatment Panel (ATP) III was used for MetS definition. The HBI was calculated by a 125‐item food frequency questionnaire with standard criteria. The association between HBI and MetS and its components was evaluated by univariate regression. Multivariate regression with the backward method was used for adjusting confounders. p < .05 was considered as statistically significant. Compared to the first quartile, it was observed that HBI in the last quartile was significantly related to lower odds of MetS in the multivariate analysis (odds ratio [OR] = 0.72; 95% confidence interval [CI]: 0.60–0.87, p < .001). Also, we observed a significant association between the last quartile of HBI with lower odds of high waist circumference (WC) (OR = 0.55; 95% CI: 0.45–0.67, p < .002). Our findings showed that the higher HBI score reduced MetS odds and WC. Therefore, to reduce the odds of MetS, a healthy pattern of beverage consumption, including drinking water, low‐fat milk, unsweetened tea, and coffee, and reducing the consumption of SSB are recommended. More studies are needed to confirm the findings.
Potential utility of urinary chemokine CCL2 to creatinine ratio in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in kidney transplant recipients
Authors: Gniewkiewicz Michal , Gozdowska Jolanta , Deborska‐Materkowska Dominika , Czerwinska Katarzyna , Perkowska‐Ptasinska Agnieszka , Burban Anna , Cieslik Aleksandra , Kosieradzki Maciej , Durlik Magdalena 
Published: June 2023

AbstractBackgroundChemokines (chemotactic cytokines) are small proteins which are engaged in many pathophysiological processes, including inflammation and homeostasis. In recent years, application of chemokines in transplant medicine was intensively studied. The aim of this study was to determine the utility of urinary chemokines CCL2 (C‐C motif ligand 2) and CXCL10 (C‐X‐C motif chemokine ligand 10) in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in renal transplant recipients.MethodsForty patients who had a protocol biopsy 1 year after renal transplantation were included. Concentrations of CCL2 and CXCL10 in urine with reference to urine creatinine were measured. All patients were under the supervision of one transplant center. Long‐term outcomes within 5 years after 1‐year posttransplant biopsy were analyzed.ResultsUrinary CCL2:Cr at the time of biopsy was significantly increased in patients who died or had graft failure. CCL2:Cr was proven to be a significant predictor of 5‐year graft failure and mortality (odds ratio [OR]: 1.09, 95% confidence interval [CI]: 1.02–1.19, p = .02; OR: 1.08, 95% CI: 1.02–1.16, p = .04; respectively).ConclusionChemokines are easily detected by current methods. In the era of personalized medicine, urinary CCL2:Cr can be considered as a factor providing complementary information regarding risk of graft failure or increased mortality.
Anomalies in agricultural trade: A Bayesian classifier approach
Authors: Khadka Savin , Gopinath Munisamy , Batarseh Feras A. 
Published: June 2023

AbstractThis study examines the uncertainty‐agricultural trade nexus. Uncertainty effects on macroeconomic indicators such as consumption and investment have been well studied. However, less is known about the relationship between uncertainty and international trade, particularly the heterogeneity of that linkage across sectors. Application of a novel data‐driven methodology—anomaly detection and classification via a Naïve Bayesian Classifier—to monthly data at the HS‐4 level finds that agricultural imports are reduced when economic policy uncertainty is high. The effects of policy‐related uncertainty are more persistent than that of supply‐side fluctuations. Anticipatory stock‐piling occurred when uncertainty is specific to trade policy.
DFT study on the catalytic decomposition of hydrogen peroxide by iron complexes of nitrilotriacetate
Authors: Chen Hsing‐Yin , Lin Yu‐Fen 
Published: June 2023

AbstractThe Fenton system in the presence of nitrilotriacetate (NTA) ligand is studied by DFT approach. The calculations show that complexation of Fe(II) with NTA significantly facilitates the H2O2 activation. The ferric‐hydroperoxo intermediate NTAFe(III)OOH predominantly decays via the disproportionation into NTAFe(II)OH2 and NTAFe(IV)O involving the formation of a μ‐1,2‐hydroperoxo‐bridged biferric intermediate. In this mechanism, the bridged hydroperoxo is reduced by hydroperoxo ligand rather than by Fe(III). On the one hand, the NTAFe(III)OOH is sluggish to undergo hydrogen abstraction; on the other hand, it is a good nucleophile that may perform aldehyde deformylation. The present calculations suggest that both ˙OH and Fe(IV)O are generated in the NTA‐assisted Fenton system. However, the polycarboxylate ligand provides a favorable environment for H2O2 to accumulate around iron ion through hydrogen bonding. This promotes the quenching of Fe(IV)O by H2O2, rationalizing why the Fe(IV)O species is hardly detected in the NTA‐assisted Fenton system.
The new advance of SALL4 in cancer: Function, regulation, and implication
Authors: Abouelnazar Fatma A. , Zhang Xiaoxin , Wang Maoye , Zhang Jiahui , Yu Dan , Zang Xueyan , Zhang Jiayin , Li Yixin , Xu Jing , Yang Qiurong , Zhou Yue , Tang Haozhou , Wang Yanzheng , Gu Jianmei , Zhang Xu 
Published: June 2023

AbstractSALL4 (split‐like protein 4) is a member of the mammalian homologs of the Drosophila homoeotic gene spalt (sal) and acts as a zinc finger transcription factor to govern the self‐renewal and pluripotency of embryonic stem cells. SALL4 expression gradually decreases during development and is even absent in most adult tissues. However, increasing evidence suggests that SALL4 expression is restored in human cancers and its aberrant expression is associated with the progression of many hematopoietic malignancies and solid tumors. The potent roles of SALL4 in regulating cancer cell proliferation, apoptosis, metastasis, and drug resistance have been reported. SALL4 plays a dual role in epigenetic modulation by acting as either an activator or a repressor of its target genes. Furthermore, SALL4 interacts with other partners to control the expression of many downstream genes and the activation of various key signaling transduction pathways. SALL4 is considered as a promising diagnostic and prognostic biomarker and therapeutic target for cancer. In this review, we highlighted the major advances in the roles and mechanisms of SALL4 in cancer and the therapeutic strategies for targeting SALL4 to treat cancer.
Ion‐beam deposited platinum as electrical contacting material in operando electron microscopy experiments at elevated temperatures
Authors: Simonsen Søren Bredmose , Ma Zhongtao , Mariegaard Elisabeth , De Angelis Salvatore , Dacayan Waynah Lou , Mølhave Kristian Speranza , Chatzichristodoulou Christodoulos 
Published: June 2023

AbstractEstablishing a stable and well conducting contacting material is critical for operando electron microscopy experiments of electrical and electrochemical devices at elevated temperatures. In this contribution, the nanostructure and electrical conductivity of ion beam deposited Pt are investigated both in vacuum and in oxygen as a function of temperature. Its microstructure is relatively stable up to a temperature of approx. 800°C and up to an applied current density of approx. 100 kA/cm2. Its conductivity increases with temperature, attributed to densification, with changes in the hydrocarbon matrix being less important. Recommendations are provided with respect to the Pt deposition parameters in terms of maximizing stability and minimizing electrical resistance.Research Highlights
It is feasible to use ion beam deposited Pt as electrical contacting material in operando electron microscopy.
The deposited Pt is relatively stable up to 800°C and approx. 100 kA/cm2.
The resistivity can be reduced by increasing the applied ion current during deposition and by thermal annealing at a temperature of 500°C in a few mbar of oxygen.
Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus)
Authors: Abd‐Elhafeez Hanan H. , Rutland Catrin Sian , Soliman Soha A. 
Published: June 2023

AbstractTelocytes (TCs) are present in a broad range of species and regulate processes including homeostasis, tissue regeneration and immunosurveillance. This novel study describes the morphological features of migrating TCs and their role during cartilage development within the air‐breathing organ in Clarias gariepinus, the African sharptooth catfish. Light microscopy (LM), transmission electron microscopy (TEM), and immunohistochemistry (IHC) were used to examine the TCs. TCs had a cell body and telopodes which formed 3D networks in the cartilage canals and extended their telopodes to become the foremost cellular elements penetrating the cartilage matrix. The TCs were also rich in lysosomes that secreted products to the extracellular matrix (ECM). In addition, TCs formed a homocellular synaptic‐like structure that had a synaptic cleft, and the presynaptic portion consisted of a slightly expanded terminal of the telopodes which contained intermediate filaments and secretory vesicles. Gap junctions were also identified between TCs, which also connected to mesenchymal stem cells, differentiating chondrogenic cells, macrophages, apoptotic cells, and endothelial cells. In addition to describing the basic morphology of TCs, the current study also investigated migrating TCs. The TC telopodes acquired an irregular contour when migrating rather than exhibiting an extended profile. Migrating TCs additionally had ill‐defined cell bodies, condensed chromatin, thickened telopodes, and podoms which were closely attached to the cell body. The TCs also expressed markers for MMP‐9, CD117, CD34 and RhoA. In conclusion, TCs may play multiple roles during development and maturation, including promoting angiogenesis, cell migration, and regulating stem cell differentiation.Research Highlights
Clarias gariepinus telocytes form 3D networks, extend their telopodes and contain lysosomes.
Telocytes form a homocellular synaptic‐like structure including clefts and a slightly expanded terminal of the telopodes which contains intermediate filaments and secretory vesicles.
Gap junctions form between telocytes, which also connect to mesenchymal stem cells, differentiating chondrogenic cells, macrophages, apoptotic cells, and endothelial cells.
Migrating telocytes were discovered which had ill‐defined cell bodies, condensed chromatin, thickened telopodes exhibiting irregular contours, and podoms which were closely attached to the cell body.