bluuebunny/crossref_metadata_2025_split huggingface dataset:
Added value of 18F-FDOPA PET to the management of high-grade glioma patients after their initial treatment: a prospective multicentre study
Authors: Darcourt Jacques , Bourg Veronique , Gal Jocelyn , Schiappa Renaud , Blonski Marie , Almairac Fabien , Mondot Lidiane , Lejeune Florence , Collombier Laurent , Kas Aurelie , Taillandier Luc , Verger Antoine 
Published: January 2023

Abstract
Background. Diagnostic value of 18F-fluoro-L-dihydrophenylalanine (18F-FDOPA) PET in patients with suspected recurrent gliomas is recognised. We conducted a multicentre prospective study to assess its added value in the practical management of patients suspected of recurrence of high grade gliomas (HGG).
Methods. Patients with a proven HGG (WHO grade III and IV) were referred to the multidisciplinary neuro-oncology board (MNOB) during their follow-up after initial standard of care treatment and when MRI findings were not fully conclusive. Each case was discussed in 2 steps. For step 1, a diagnosis and a management proposal was made only based on the clinical and the MRI data. For step 2, the same process was repeated taking the 18F-FDOPA PET results into consideration. A level of confidence of the decisions was assigned to each step. Changes in diagnosis and management induced by 18F-FDOPA PET information were measured. When unchanged, the difference in the confidence of the decisions were assessed. The diagnostic performances of each step was measured.
Results. 107 patients underwent a total of 138 MNOB assessments. The proposed diagnosis changed between step 1 and step 2 in 37 cases (26.8%) and the proposed management changed in 31 cases (22.5%). When the management did not change, the confidence in the MNOB final decision was increased in 87 cases (81.3 %). Step 1 had a sensitivity, specificity and accuracy of 83%, 58% and 66% and step 2, 86%, 64% and 71% respectively.
Conclusion. 18F-FDOPA PET adds significant information for the follow-up of HGG patients in clinical practice.
How Oral Conditions and Oral Substance Abuse Can Affect the Oral Health Related Quality of Life of Patients With Acquired Immunodeficiency Virus?
Authors: Chimbinha Ítalo Gustavo , de Morais Sidney Raiski , Piovesan Chaiana , Pinto Tatiana Perrone Militz , Ardenghi Thiago Machado , Guedes Renata 
Published: January 2023

AbstractBackground This survey’s aim was to evaluate the impact of oral conditions and oral substance abuse on the oral health related quality of adult patients carrying the virus that causes acquired immunodeficiency syndrome, in Santa Maria city, Brazil. Methods This cross-sectional survey examined all HIV patients between 18 and 65 years in treatment and follow-up at the outpatient Service of infectious diseases in Santa Maria. Three previously trained and calibrated examiners conducted the clinical examination. A structured questionnaire was used to assess socioeconomic characteristics and oral substance abuse. To evaluate the oral health related to the quality of life the OHIP-14 questionnaire was used. The data was analyzed with multivariate regression of Poisson. Results Individuals with the HIV virus who had DMF-t > 3 showed a greater impact on their quality of life compared to those with DMF-t ≤ 3 (RP 1.03; 95 CI% 1.01–1.06). Drug users had a greater impact than those who did not use drugs (RP 1.52; 95 CI% 1.06–2.19). Antiretroviral therapy users and smoking habits did not influence oral health-related quality of life. HIV patients without social support had a greater impact on their quality of life compared to patients with social support (RP 1.71; 95CI% 1.20–2.44). Furthermore, the use of toothpaste showed to be a protective factor (RP 0.49; 95 CI% 0.32–0.74). Conclusion Presence of tooth decay, absence of social support, use of drugs, and use of toothpaste affects the oral heath quality of life in adult HIV patients.
Pulmonary Carcinoid Tumour of Endobronchial Presentation: A Case Report
Authors: Valderrama-Saldaña Mayra , Cubas W Samir , Reina Helen , Somocursio José , Small Max 
Published: January 2023

Abstract

Introduction: Lung carcinoid tumors account for 1-2 % of malignant lung neoplasms. Early diagnosis is crucial, and surgery at an early stage may improve the clinical picture and may even be a curative option.
Case report: We present the case of a 78-year-old woman with a history of poorly controlled arterial hypertension, anxious syndrome, irritable bowel syndrome, and paroxysmal palpitations for the last two years. Imaging showed a left hilar nodular lesion causing endobronchial obstruction in the left lower lobe. Anatomopathology revealed a low-grade pulmonary neuroendocrine tumor, and pulmonary resection with nodal staging was promptly considered.
Conclusions: The diagnosis of pulmonary carcinoid tumor is challenging; therefore, it is necessary to maintain suspicion in patients with non-specific and/or persistent respiratory symptoms, and complete resection and prolonged close follow-up should be considered despite a satisfactory postoperative course.
Clonal hematopoiesis in idiopathic cytopenia of undetermined significance
Authors: Wu Hanyang , Gu Chao-yang , Liu Shuang , Dong Qiao-feng , Dong Lin , Wang Liang , Wang Xinru , Cui Si-yuan , Li Zhao , Liu Xin-guang , Ma Daoxin , Ji Chunyan 
Published: January 2023

Abstract
The mutation landscapes and clinical significance of clonal hematopoiesis (CH) in idiopathic cytopenia of undetermined significance (ICUS) is still unclear. Based on the next-generation sequencingdata of 281 ICUS patients, we sought to depict the profile of CH in ICUS and evaluate its role in disease progression. It was found that CH occurred in 27% of the patients, and was more prevalent in male patients. The incidence of CH accumulated with age. AXSL1, DNMT3A, U2AF1 and TET2 were the most frequently mutated genes. Exclusive mutations existed in DNMT3A and U2AF1, and co-occurring mutations were found between SRSF2 and TET2, SRSF2 and WT1. Fifteen of the 281 ICUS patients transformed to hematological malignancies, and CH group had a higher incidence of leukemic transformation than non-CH group. Variant allele frequencies (VAFs) of the mutated genes, such asASXL1, U2AF1 and TP53, showed an obvious elevation after disease transformation. Moreover, CH patients had a shorter overall survival and progression-free survival. These data indicated that CH was a common phenomenon in ICUS patients, and it contributed greatly to the increased risk of disease progression, suggesting the significance of gene mutation monitoring in ICUS management.
Contribution of Timescale Patterns to Photoplethysmography-based Blood Pressure Estimation
Authors: Xing Xiaoman , Huang Rui , Jiang Chenyu , Dong Wen-fei 
Published: January 2023

Abstract
Objective: Single-site photoplethysmography (PPG)-based blood pressure (BP) estimation has raised a lot of interest due to its compactness and low cost. However, this method relies on PPG morphological features, which are sensitive to noise and measurement conditions. The underlying physiological mechanism was also unclear at this moment. In this study, we propose to add timescale patterns of PPG to improve the BP estimation performance and clarify the underlying mechanism.
Methods: In-silico simulation with a four-element Windkessel model showed that peripheral resistance and vascular compliance variation during a cardiac cycle correlated with PPG’s long- and short-term self-similarity, which significantly correlated with BP. A publicly available dataset was used to validate the simulation predictions using mutual information analysis and regression performance assessment.
Results: The hemodynamic property of the cardiovascular system determines how fast PPG responds to a stimulus. High vascular compliance or peripheral resistance leads to prolonged and overlapped responses, which could be described by timescale patterns. Adding these patterns significantly increased the PPG-BP mutual information and improved the BP estimation performance. Compared to algorithms with morphological and biometric features, the mean absolute error (MAE) of calibrated systolic BP (SBP) reduced from 5.37mmHg to 4.51mmHg, while the MAE of calibration-free diastolic BP (DBP) reduced from 3.46mmHg to 2.81mmHg. The median intra-subject correlation between SBP/DBP estimation and ground truth increased from 0.63/0.34 to 0.80/0.68, which means the intrinsic BP fluctuation was better captured.
Conclusion: Timescale patterns were vital to single-site PPG-based BP estimation. Understanding its physiological implication may help us design algorithms with clear interpretability and simplified structures.
Treatment strategy for BVO-ME based on long-term outcomes correlating retinal structure by OCT image and visual acuity
Authors: Fujiwara Ryo , Mori Hidetsugu , Kimura Motoki , Yamada Haruhiko , Takahasi Kanji , Hattori Yuki 
Published: January 2023

Abstract

Purpose: Intravitreal anti-vascular endothelial growth factor (VEGF) is a mainstream treatment for reducing ME secondary to BRVO (BVO-ME）. Regrettably, most reports of intravitreal anti-VEGF for BVO-ME have disclosed only short-term outcomes. Here, we characterized long-term indicators for the visual prognosis of patients with BVO-ME, including the correlation between retinal structure by OCT and visual acuity.
Methods: Patients with BVO-ME were retrospectively recruited based on clinical records in Kansai Medical University Hospital from June 2012 to March 2022. Patients were divided into two groups according to BCVA at the final visit: Group A (≥0.7) and Group B (≤0.6).
Results: 47 eyes from 45 patients were assessed. The mean follow-up period from initial to final visit was 64.38 ± 15.07 (range, 38-100) months. BCVA in Group A (n = 32) was significantly greater than in Group B (n = 15) at all timepoints. The ratio that the number of eyes which the EZ band and the foveal bulge were intact in Group A was higher than in Group B (p = 0.0004 and p = 0.0002, respectively). The ratio that the number of eyes which recurrence SRD was observed by the final visit in Group A was lower than in Group B (p = 0.0485).
Conclusion: The integrity of the EZ band and an intact foveal bulge were significant predictors for visual acuity. In contrast, recurrent SRD led to poor visual acuity in the long term, even if BCVA was good in the short term.
A novel approach for decoupling and separating the thermal positioning errors of machining center linear axes
Authors: Yao Xiaopeng , Hu Teng , Wang Xiaohu , Mi Liang , Yin Guofu 
Published: January 2023

Abstract
CNC machining center linear axis thermal positioning errors, seen as the synthetic consequences of geometric and thermal errors, respectively generated due to the manufacturing and assembling inaccuracies and the asymmetric thermal deformation of the machining center structure, are significantly affected by varying position of the cutting point and shifting state of temperature field. Hence, developing a practical approach to reduce or even eliminate thermal positioning errors is crucial. This paper proposes a novel approach to decouple and separate machining center linear axis thermal positioning errors, based on which a highly accurate prediction model of the thermal positioning error is formulated. Firstly, a new concept on thermal positioning error sensitivity is presented where grey correlation analysis is borrowed to characterize the mapping between varying temperature fields and thermal positioning errors, according to which the sensor sensitivities and distributions are derived and optimized, respectively. Then, the thermal positioning errors are decoupled and separated into geometric and thermal errors by adopting multiple linear regression and GM (1, n) algorithms, respectively. Finally, the corresponding embedded compensation module is also developed within the SIEMENS 840D CNC system to realize the online compensation strategy providing the engineering applications. Experimental validations are performed on a commercial machining center, where the thermal positioning errors of the Z-axis are measured with the help of a laser interferometer testing kit and a thermal inspection instrument. The data comparisons indicate that the maximum thermal positioning errors of the Z-axis in the cold and warm state are respectively decreased for 86.5% and 71.6% after activating the compensation module, which also suggests that the proposed approach is adequate and accurate to decouple and separate the thermal positioning errors.
Risk factors affecting patients survival with colorectal cancer in Morocco : Survival Analysis using an Interpretable Machine Learning Approach
Authors: Badisy Imad El , BenBrahim Zineb , Khalis Mohamed , Elansari Soukaina , ElHitmi Youssef , Abbas Fouad , Mellas Nawfal , Rhazi Karima EL 
Published: January 2023

Abstract

The aim of our study was to assess the overall survival rates for colorectal patients in Morocco and to identify strong prognostic factors using a novel approach combining survival random forest and the Cox model. Covariate selection was performed using the variable importance based on permutation and partial dependence plots were displayed to explore in depth the relationship between the estimated partial effect of a given predictor and survival rates. The predictive performance was measured by two metrics, the Concordance Index (C-index) and the Brier Score (BS). Overall survival rates at 1, 2 and 3 years were, respectively, 87% (SE = 0.02; CI-95% = 0.84–0.91), 77% (SE = 0.02; CI-95% = 0.73–0.82) and 60% (SE = 0.03; CI-95% = 0.54–0.66). In the Cox model after adjustment for all covariates, sex, tumor differentiation had no significant effect on prognosis, but rather tumor site had a significant effect. The variable importance obtained from RSF strengthens that surgery, stage, insurance, residency, and age were the most important prognostic factors. The discriminative capacity of the Cox PH and RSF was, respectively, 0.771 and 0.798 for the C-index, while the accuracy of the Cox PH and RSF was, respectively, 0.257 and 0.207 for the Brier Score. This shows that RSF had both better discriminative capacity and predictive accuracy. Our results show that patients who are older than 70, living in rural areas, without health insurance, at a distant stage and who have not had surgery constitute a subgroup of patients with poor prognosis.
Association between single nucleotide variants and severe chronic pain in older adult patients after lower extremity arthroplasty
Authors: Xu Rui , Jin Yinan , Tang Suhong , Wang Wenwen , Sun Yu-E , Liu Yue , Zhang Wei , Hou Bailing , Huang Yulin , Ma Zhengliang 
Published: January 2023

Abstract
Background

Hip or knee osteoarthritis (OA) is one of the main causes of disability worldwide and occurs mostly in the older adults. Total hip or knee arthroplasty is the most effective method to treat OA. However, severe postsurgical pain leading to a poor prognosis. So, investigating the population genetics and genes related to severe chronic pain in older adult patients after lower extremity arthroplasty is helpful to improve the quality of treatment.

Methods

We collected blood samples from elderly patients who underwent lower extremity arthroplasty from September 2020 to February 2021 at the Drum Tower Hospital Affiliated to Nanjing University Medical School. The enrolled patients provided measures of pain intensity using the numerical rating scale on the 90th day after surgery. Patients were divided into the case group (Group A) and the control group (Group B) including 10 patients respectively by the numerical rating scale. DNA was isolated from the blood samples of the two groups for whole-exome sequencing.

Results

In total, 661 variants were identified in the 507 gene regions that were significantly different between both groups (P < 0.05), including CASP5, RASGEF1A, CYP4B1, etc. These genes are mainly involved in biological processes, including cell–cell adhesion, ECM–receptor interaction, metabolism, secretion of bioactive substances, ion binding and transport, regulation of DNA methylation, and chromatin assembly.

Conclusions

The current study shows some variants within genes are significantly associated with severe postsurgical chronic pain in older adult patients after lower extremity arthroplasty, indicating a genetic predisposition for chronic postsurgical pain.
The study was registered according to ICMJE guidelines. The trial registration number is ChiCTR2000031655 and registration date is April 6th, 2020.
The Interactive Impact of Pain and Task Difficulty on Effort-Related Cardiovascular Reactivity
Authors: Cancela Tamara , Silvestrini Nicolas 
Published: January 2023

Abstract
Objective
Multiple evidence suggests that pain impairs cognitive task performance. However, much less is known about the impact of pain on cognitive effort, i.e., the mobilization of resources during cognitive task performance. The present experiment investigated how pain interacts with task difficulty to influence the allocation of effort.
Methods
Healthy volunteers were administered individually adjusted painful or nonpainful thermal stimulations during an easy or difficult cognitive task. Effort was assessed as cardiovascular reactivity during task performance, in particular the cardiac pre-ejection period (PEP). Based on pain research showing that pain adds supplementary demand on cognitive functioning, we expected pain to influence effort because it should increase subjective task difficulty. Consequently, drawing on motivational intensity theory, we predicted and found a crossover interaction between pain and task difficulty on PEP reactivity.
Results
Pain led to stronger effort than nonpainful stimulations in the easy task, which was expected due to additional pain-related demand. However, nonpainful stimulations led to stronger reactivity than painful stimulations in the difficult task, which was predicted due to too high required effort and disengagement in the pain condition. Moreover, our results showed that pain increased perceived task difficulty.
Conclusions
These findings provide first evidence that objective task difficulty moderates physical pain’s impact on effort assessed as cardiovascular response. Clinical implications in the context of chronic pain are discussed.
Renal lobulation – a benign anatomical variation?
Authors: Covantsev Serghei , Arnaut Oleg , Mulaeva Karina , Belic Olga 
Published: January 2023

Abstract
Introduction: Renal lobulation (also known as fetal or embryonic lobulation) is a rare variation of development when renal lobules have a visible anatomical space between them. Fetal lobulation is considered to be rare in adult patients and can be seen in 0.5-4% of cases.
Material and methods: The study was conducted on 54 human kidneys from patients who died due to causes unrelated to renal pathology and were fixed in a 10% formaldehyde solution. After seven days of preservation in a formaldehyde solution the kidneys were dissected manually. The data acquired during the study was analyzed statistically (Spearmans correlation, cross-tabulation analysis, Mann-Whitney test and logistic regression).
Results: The group with fetal lobulation (n=16) was associated with a length M=9.89 (SD=0.6, p=0.15). By comparison the kidneys without lobulation (n=38) were associated with a numerically bigger length M=10.29 (SD=0.607, p=0.098). To test the hypothesis that lobulation is associated with a statistically significant different length a Mann-Whitney test was performed, which indicated that the length of the kidneys is smaller in case of lobulation U=198, Z= -2.04, p=0.04. cross-tabulation also demonstrated that kidney lobulation may be influenced by the presence of polar arteries with r=0.41 (p<0.02). The likelihood ratio was 7.28, df 1, p=0.003 odds ratio 6.857 (CI 95%=1.84-25.61). There was no relationship between fetal lobulation and number of major calyces or sex (p>0.05). A logistic regression was performed to ascertain the effects of polar arteries on the likelihood that kidneys have cortex lobulation (Step 1) and the effect of both polar arteries and length on the likelihood that kidneys have cortex lobulation (Step 2). In the step 1 the logistic regression model was statistically significant, χ2(1) = 8.73, p = 0.003. The model explained 21.2% (Nagelkerke R2) of the variance in kidney lobulation and correctly classified 75.9% of cases. Kidneys with lobulation were 6.85 times more likely to have polar arteries than kidneys without lobulation.
Conclusions: The data from our research indicates that even though no pathological conditions are linked until now with lobulated kidneys the incidence of vascular variations (specifically polar arteries) is higher when there is persistent fetal lobulation. Therefore, this condition can be caused by hemodynamic changes inside the organ. Kidneys with fetal lobulation also tend to be smaller. The proposed model need validation and completion up to determination coefficient value 0.8.
Trajectories of Sleep Disturbance and Self-Management of Chronic Conditions during COVID-19 among Middle-aged and Older Adults
Authors: Kim Minjee , Opsasnick Lauren , Batio Stephanie , Benavente Julia Y. , Bonham Morgan , Zheng Pauline , Lovett Rebecca M. , Bailey Stacy C. , Kwasny Mary , Ladner Daniela P. , Chou Sherry HY. , Linder Jeffrey A. , Weintraub Sandra , Luo Yuan , Zee Phyllis C. , Wolf Michael S. 
Published: January 2023

Abstract

Background:The COVID-19 pandemic has had a widespread impact on sleep quality, yet little is known about the prevalence of sleep disturbance and its impact on self-management of chronic conditions during the ongoing pandemic.
Objective: To evaluate trajectories of sleep disturbance, and their associations with one’s capacity to self-manage chronic conditions.
Design: A longitudinal cohort study linked to 3 active clinical trials and 2 cohort studies with 5 time points of sleep data collection (July 15, 2020 – May 23, 2022).
Participants: Adults living with chronic conditions who completed sleep questionnaires for two or more time points.
Exposure: Trajectories of self-reported sleep disturbance across 5 time points.
Main Outcomes: 3 self-reported measures of self-management capacity, including subjective cognitive decline, medication adherence, and self-efficacy for managing chronic disease.
Results: 549 adults aged 23 to 91 years were included in the analysis. Two thirds had 3 or more chronic conditions; 42.4% of participants followed a trajectory of moderate or high likelihood of persistent sleep disturbance across the study period. Moderate or high likelihood of sleep disturbance was associated with older age (RR 1.57, 95% CI 1.09, 2.26, P<.05), persistent stress (RR 1.54, 95% CI 1.16, 2.06, P=.003), poorer physical function (RR 1.57, 95% CI 1.17, 2.13, P=.003), greater anxiety (RR 1.40, 95% CI 1.04, 1.87, P=.03) and depression (RR 1.63, 95% CI 1.20, 2.22, P=.002). Moderate or high likelihood of sleep disturbance was also independently associated with subjective cognitive decline, poorer medication adherence, and worse self-efficacy for managing chronic diseases (all P<.001).
Conclusions: Persistent sleep disturbance during the pandemic may be an important risk factor for inadequate chronic disease self-management and potentially poor health outcomes in adults living with chronic conditions. Public health and health system strategies might consider monitoring sleep quality in adults with chronic conditions to optimize health outcomes.