bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medical scientific conferences and social networks
Authors: Alfimov A. Е. , Trofimova A. A. , Matvienko A. A. , Kodalaeva M. V. 
Published: April 2023

Introduction. Medical conferences are a key source of new and relevant knowledge for practicing physicians. Physicians use social media to share this knowledge with their colleagues. As a result, there is a lot of discussion on social media about the topics covered in the scientific presentations. This initiative has some educational value, which is being actively explored. The discussions around such posts make ideas, insights, opinions and experiences of peer-colleagues easily available. They also immediately raise awareness of new clinical research and scientific data.Objective. We studied how often Russian physicians use available social networks (vrachirf.ru, doktornarabote.ru. vk.com) to share information from scientific conferences with their colleagues.Materials and мethods. We searched for posts using keywords related to medical conferences and selected among the search results the entries whose authors, as physicians, disclosed selected elements of the content of scientific presentations.Results. We identified 65 entries over the past 4–12 months where physicians shared facts and ideas presented at scientific conferences. Entries posted on professional physicians’ social networks with access restricted to lay public generated vigorous meaningful discussions, unlike posts on the mainstream social network vk.com.Conclusions. Doctors very rarely share on social media the facts and ideas presented at Russian scientific medical conferences. Physicians demonstrate significant interest in these posts and actively discuss them. Further study should reveal the educational potential of the described phenomenon and suggest the pathways to its effective utilization.
Effect of dihydroquercetin on the toxic properties of nickel nanoparticles
Authors: Gmoshinski Ivan , Ananyan Mikhail , Shipelin Vladimir , Riger Nikolay , Trushina Eleonora , Mustafina Oksana , Guseva Galina , Balakina Anastasya , Kolobanov Alexey , Khotimchenko Sergey , Ozherelkov Dmitriy 
Published: April 2023

Dihydroquercetin (3,5,7,3',4'-pentahydroxy-flavanone) is known for its powerful antioxidant, organ-protective, and antiinflammatory activities that can be applied to heavy-metal intoxication. The present research objective was to evaluate the possible protective potential of dietary dihydroquercetin in a rat model of subacute (92 days) intoxication with nickel nanoparticles.
The experiment involved five groups of twelve male Wistar rats in each. Group 1 served as control. Other groups received nickel nanoparticles as part of their diet. Groups 2 and 4 received nickel nanoparticles with an average diameter of 53.7 nm (NiNP1), while groups 3 and 5 were fed with nanoparticles with an average diameter of 70.9 nm (NiNP2). The dose was calculated as 10 mg/kg b.w. Groups 4 and 5 also received 23 mg/kg b.w. of water-soluble stabilized dihydroquercetin with drinking water.
After the dihydroquercetin treatment, the group that consumed 53.7 nm nickel nanoparticles demonstrated lower blood serum glucose, triglycerides, low-density lipoprotein cholesterol, and creatinine. Dihydroquercetin prevented the increase in total protein and albumin fraction associated with nickel nanoparticles intake. The experimental rats also demonstrated lower levels of pro-inflammatory cytokines IL-1β, IL-4, IL-6, and IL-17A, as well as a lower relative spleen weight after the treatment. In the group exposed to 53.7 nm nickel nanoparticles, the dihydroquercetin treatment increased the ratio of cytokines IL-10/IL-17A and decreased the level of circulating FABP2 protein, which is a biomarker of increased intestinal barrier permeability. In the group that received 70.9 nm nickel nanoparticles, the dihydroquercetin treatment inhibited the expression of the fibrogenic Timp3 gene in the liver. In the group that received 53.7 nm nickel nanoparticles, dihydroquercetin partially improved the violated morphology indexes in liver and kidney tissue. However, dihydroquercetin restored neither the content of reduced glutathione in the liver nor the indicators of selenium safety, which were suppressed under the effect of nickel nanoparticles. Moreover, the treatment failed to restore the low locomotor activity in the elevated plus maze test.
Dihydroquercetin treatment showed some signs of detoxication and anti-inflammation in rats subjected to nickel nanoparticles. However, additional preclinical studies are necessary to substantiate its prophylactic potential in cases of exposure to nanoparticles of nickel and other heavy metals.
Recent Progress on Synthesis of Functionalized 1,5-Disubstituted Triazoles
Authors: Jaiswal Manoj K. , Gupta Abhishek , Ansari Faisal J. , Pandey Vinay K. , Tiwari Vinod K. 
Published: April 2023

Abstract:
Immediately after the invention of ‘Click Chemistry’ in 2002, the regioselective 1,2,3-triazole scaffolds resulted from respective organic azides and terminal alkynes under Cu(I) cataly-sis have been well recognized as the functional heterocyclic core at the centre of modern organic chemistry, medicinal chemistry, and material sciences. This CuAAC reaction has several notable features including excellent regioselectivity, high-to-excellent yields, easy to execute, short reac-tion time, modular in nature, mild condition, readily available starting materials, etc. Moreover, the resulting regioselective triazoles can serve as amide bond isosteres, a privileged functional group in drug discovery and development. More than hundreds of reviews had been devoted to the ‘Click Chemistry’ in special reference to 1,4-disubstituted triazoles, while only little efforts were made for an opposite regioisomer i.e., 1,5-disubstituted triazole. Herein, we have presented vari-ous classical approaches for an expeditious synthesis of a wide range of biologically relevant 1,5-disubstituted 1,2,3-triazole analogues. The syntheses of such a class of diversly functionalized tri-azoles have emerged as a crucial investigation in the domain of chemistry and biology. This tuto-rial review covers the literature assessment on the development of various synthetic protocols for the functionalized 1,5-disubstituted triazoles reported during the last 12 years.
Kaempferol: Topical Applications and Nanoformulations in the Treatment
of Diseases
Authors: Preeti  , Akhtar Juber , Verma Amit , Badruddeen  , Khan Mohammad Irfan , Ahmad Mohammad 
Published: April 2023

Abstract:
Kaempferol, a natural flavonoid found in numerous fruits, vegetables, and herbs, possesses
many pharmacological activities such as antioxidant, anti-inflammatory and anti-cancer.
Kaempferol has low aqueous solubility and hence has poor oral bioavailability. Numerous promising
techniques were used to enhance its absorption and structural transformation to deliver
kaempferol. Novel pharmaceutical technologies, including nanotechnology, carrier complex and
cocrystals have been established. However, this review discusses how to deliver kaempferol via
topical route in many diseases. This is the earliest review that aims to provide updated information
on chemistry, bioavailability, biosynthesis, therapeutic effects and available nanoformulations
of kaempferol. It also provides future directions so that the overall bioavailability of
kaempferol might be improved, and it may show expansive applications.
The Current Status and Future Direction of Extracellular Nano-vesicles in
the Alleviation of Skin Disorders
Authors: Ghorbani Raziyeh , Hosseinzadeh Simzar , Azari Arezo , Taghipour Niloofar , Soleimani Masoud , Rahimpour Azam , Abbaszadeh Hojjat Allah 
Published: April 2023

Abstract:
Exosomes are extracellular vesicles (EVs) that originate from endocytic membranes. The transfer
of biomolecules and biological compounds such as enzymes, proteins, RNA, lipids, and cellular waste
disposal through exosomes plays an essential function in cell-cell communication and regulation of pathological
and physiological processes in skin disease. The skin is one of the vital organs that makes up
about 8% of the total body mass. This organ consists of three layers, epidermis, dermis, and hypodermis
that cover the outer surface of the body. Heterogeneity and endogeneity of exosomes is an advantage that
distinguishes them from nanoparticles and liposomes and leads to their widespread usage in the remedy of
dermal diseases. The biocompatible nature of these extracellular vesicles has attracted the attention of
many health researchers. In this review article, we will first discuss the biogenesis of exosomes, their
contents, separation methods, and the advantages and disadvantages of exosomes. Then we will highlight
recent developments related to the therapeutic applications of exosomes in the treatment of common skin
disorders like atopic dermatitis, alopecia, epidermolysis bullosa, keloid, melanoma, psoriasis, and systemic
sclerosis.
SARS-CoV-2 Infection to Premature Neuronal Aging and
Neurodegenerative Diseases: Is there any Connection with Hypoxia?
Authors: Sivagurunathan Narmadhaa , Calivarathan Latchoumycandane 
Published: April 2023

Abstract:
The pandemic of coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, has become
a global concern as it leads to a spectrum of mild to severe symptoms and increases death tolls
around the world. Severe COVID-19 results in acute respiratory distress syndrome, hypoxia, and multi-
organ dysfunction. However, the long-term effects of post-COVID-19 infection are still unknown.
Based on the emerging evidence, there is a high possibility that COVID-19 infection accelerates premature
neuronal aging and increases the risk of age-related neurodegenerative diseases in mild to severely
infected patients during the post-COVID period. Several studies correlate COVID-19 infection
with neuronal effects, though the mechanism through which they contribute to the aggravation of neuroinflammation
and neurodegeneration is still under investigation. SARS-CoV-2 predominantly targets
pulmonary tissues and interferes with gas exchange, leading to systemic hypoxia. The neurons in
the brain require a constant supply of oxygen for their proper functioning, suggesting that they are
more vulnerable to any alteration in oxygen saturation level that results in neuronal injury with or
without neuroinflammation. We hypothesize that hypoxia is one of the major clinical manifestations of
severe SARS-CoV-2 infection; it directly or indirectly contributes to premature neuronal aging, neuroinflammation,
and neurodegeneration by altering the expression of various genes responsible for the
survival of the cells. This review focuses on the interplay between COVID-19 infection, hypoxia,
premature neuronal aging, and neurodegenerative diseases and provides a novel insight into the molecular
mechanisms of neurodegeneration.
A New Approach to the Position of Acupoints on the Back of Humans
Authors: Xie Shenglong , Liu Zijing , Zhang Liangan , Song Fengfeng 
Published: April 2023

Aim:
In order to realize the position of acupoints on the back of humans, a new acupoints positioning
approach combined with machine vision technology is proposed in this paper.

Background:
The acupuncture point (acupoint) is an important reference in the treatment of Traditional
Chinese Medicine (TCM). However, the traditional acupoints positioning method mainly depends on
manpower, which has the disadvantages of low efficiency and relying on practical experience heavily.

Objective:
In order to realize the position of acupoints on the back of humans, a new acupoints positioning
approach combined with machine vision technology is proposed in this paper.

Methods:
Firstly, the distribution of acupoints on the back of humans are determined according to the
meridian theory, and the coordinate of each acupoint are established based on the approach of fingercun
measurement, after review of previous literature and patents. Secondly, the principle of the proposed
acupoints positioning method is introduced based on the skeleton model of humans. Finally, the effectiveness
of the proposed approach is validated by experimental testing.

Results:
The value of emax is around 3.5mm and those of emae and erms are smaller than 0.25mm and
0.45mm, respectively.

Conclusion:
The experimental results prove that the proposed approach possesses the capability of
good adaptive capability and high.
Decision Aids for Patients With Head and Neck Cancer: Qualitative Elicitation of Design Recommendations From Patient End Users
Authors: Stringer Eleah , Lum Julian J , Livergant Jonathan , Kushniruk Andre W 
Published: April 2023

Background
Patients with head and neck cancer (HNC) carry a clinically significant symptom burden, have alterations in function (eg, impaired ability to chew, swallow, and talk), and decrease in quality of life. Furthermore, treatment impacts social activities and interactions as patients report reduced sexuality and shoulder the highest rates of depression across cancer types. Patients suffer undue anxiety because they find the treatment incomprehensible, which is partially a function of limited, understandable information. Patients’ perceptions of having obtained adequate information prior to and during treatment are predictive of positive outcomes. Providing patient-centered decision support and utilizing visual images may increase understanding of treatment options and associated risks to improve satisfaction with their decision and consultation, while reducing decisional conflict.

Objective
This study aims to gather requirements from survivors of HNC on the utility of key visual components to be used in the design of an electronic decision aid (eDA) to assist with decision-making on treatment options.

Methods
Informed by a scoping review on eDAs for patients with HNC, screens and visualizations for an eDA were created and then presented to 12 survivors of HNC for feedback on their utility, features, and further requirements. The semistructured interviews were video-recorded and thematically analyzed to inform co-design recommendations.

Results
A total of 9 themes were organized into 2 categories. The first category, eDAs and decision support, included 3 themes: familiarity with DAs, support of concept, and versatility of the prototype. The second category, evaluation of mock-up, contained 6 themes: reaction to the screens and visualizations, favorite features, complexity, preference for customizability, presentation device, and suggestions for improvement.

Conclusions
All participants felt an eDA, used in the presence of their oncologist, would support a more thorough and transparent explanation of treatment or augment the quality of education received. Participants liked the simple design of the mock-ups they were shown but, ultimately, desired customizability to adapt the eDA to their individual information needs. This research highlights the value of user-centered design, rooted in acceptability and utility, in medical health informatics, recognizing cancer survivors as the ultimate knowledge holders. This research highlights the value of incorporating visuals into technology-based innovations to engage all patients in treatment decisions.
Expectations of Anesthesiology and Intensive Care Professionals Toward Artificial Intelligence: Observational Study
Authors: Kloka Jan Andreas , Holtmann Sophie C , Nürenberg-Goloub Elina , Piekarski Florian , Zacharowski Kai , Friedrichson Benjamin 
Published: April 2023

Background
Artificial intelligence (AI) applications offer numerous opportunities to improve health care. To be used in the intensive care unit, AI must meet the needs of staff, and potential barriers must be addressed through joint action by all stakeholders. It is thus critical to assess the needs and concerns of anesthesiologists and intensive care physicians related to AI in health care throughout Europe.

Objective
This Europe-wide, cross-sectional observational study investigates how potential users of AI systems in anesthesiology and intensive care assess the opportunities and risks of the new technology. The web-based questionnaire was based on the established analytic model of acceptance of innovations by Rogers to record 5 stages of innovation acceptance.

Methods
The questionnaire was sent twice in 2 months (March 11, 2021, and November 5, 2021) through the European Society of Anaesthesiology and Intensive Care (ESAIC) member email distribution list. A total of 9294 ESAIC members were reached, of whom 728 filled out the questionnaire (response rate 728/9294, 8%). Due to missing data, 27 questionnaires were excluded. The analyses were conducted with 701 participants.

Results
A total of 701 questionnaires (female: n=299, 42%) were analyzed. Overall, 265 (37.8%) of the participants have been in contact with AI and evaluated the benefits of this technology higher (mean 3.22, SD 0.39) than participants who stated no previous contact (mean 3.01, SD 0.48). Physicians see the most benefits of AI application in early warning systems (335/701, 48% strongly agreed, and 358/701, 51% agreed). Major potential disadvantages were technical problems (236/701, 34% strongly agreed, and 410/701, 58% agreed) and handling difficulties (126/701, 18% strongly agreed, and 462/701, 66% agreed), both of which could be addressed by Europe-wide digitalization and education. In addition, the lack of a secure legal basis for the research and use of medical AI in the European Union leads doctors to expect problems with legal liability (186/701, 27% strongly agreed, and 374/701, 53% agreed) and data protection (148/701, 21% strongly agreed, and 343/701, 49% agreed).

Conclusions
Anesthesiologists and intensive care personnel are open to AI applications in their professional field and expect numerous benefits for staff and patients. Regional differences in the digitalization of the private sector are not reflected in the acceptance of AI among health care professionals. Physicians anticipate technical difficulties and lack a stable legal basis for the use of AI. Training for medical staff could increase the benefits of AI in professional medicine. Therefore, we suggest that the development and implementation of AI in health care require a solid technical, legal, and ethical basis, as well as adequate education and training of users.
Comparative study ofionogram F2 peak height from different techniques
Authors: Batista I. S. , Paula E. R. de , Abdu M. A. , Kantor I. J. 
Published: April 2023

Hicimos una intercomparaci6n entre los parámetros de altura hmF2, hpF2 y hmF2(M(3000)) deducidos de la curva h'(f) para identificar las condiciones y tendencias, si existiesen, bajo las cuales el hmF2, de acuerdo con el análisis de la altura verdadera de POLAN, podría ser mejor representado por cualquiera de los otros dos parámetros que son obtenidos por consideraciones simples. El análisis es efectuado para una estaci6n de latitud baja y otra ecuatorial, y para dos meses diferentes, representativos del verano y equinoccio locales. El análisis muestra que ambos, el hpF2 y el hmF2(M(3000)), son casi coincidentes durante la noche y dan una muy buena estimación del hmF2 (de acuerdo con el código POLAN), implicando que cualquiera de ellos puede ser usado para representar Ia altura del pico de la capa F2, dentro de la misma precisión. Sin embargo, durante el día el hpF2 da valores generalmente más altos que el hmF2(M(3000)), siendo la diferencia más pronunciada durante los meses de diciembre (verano local). Durante el día se observa también que el valor estimado de hmF2(M(3000)) supera el de hmF2 (obtenido de POLAN) en la estaci6n ecuatorial, y es inferior al mismo en la estaci6n de latitud baja, mientras que el valor de hpF2 es, en general, superior en ambas localidades.doi: Sin doi
Los paleoambientes holocenicos de la laguna babicora, Chihuahua, México
Authors: Ortega-Ramírez José R. 
Published: April 2023

En la región semiárida de la Laguna de Babícora, al noroeste del Estado de Chihuahua, se estudiaron ocho perfiles estratigráficos que cubren temporalmente el intervalo del Estadía Isotópico I. La interpretación de los resultados de los análisis edimentológicos, estadísticos, estratigráficos y siete fochamientos de 14C, permiten reconstituir y en algunos casos inferir los paleoambientes desde el Wisconsiniano Tardío hasta el Presente. La cronología paleoambiental propuesta en este trabajo es: (1) de ca. 18 ka.
A.P. a ca. 10 ka A.P. ambiente pluvial u Optimo Lacustre; (2) de ca. 10 ka A.P. a ca. 6 ka A.P., disminución de la precipitación y aumento de la temperatura, los ambientes son de tipo pantano; (3) de ca. 6 ka A.P. a 3 ka A.P. las condiciones áridas persisten; sin embargo, las estructuras, la morfología y la sedimentología de los depósitos fluviales sugieren precipitaciones ocasionales abundantes; (4) de ca. 3 ka A.P. al Presente, las condiciones semiáridas que caracterizan en nuestros días la región se instalan, precedidas por una fase de morfocstabilidad manifestada en un paleosuelo (horizonte Bt). De acuerdo con las características paleoambientalcs anteriores, suponemos que las condiciones paleoclimátieas de la región de La Laguna de Babícora fueron similares a las del suroeste de los Estados Unidos; es decir, régimen de lluvias centradas en invierno durante el Wisconsiniano Tardío, y en verano durante el Holoceno.doi: sin doi
Differential Associations of GAD Antibodies (GADA) and C-Peptide With Insulin Initiation, Glycemic Responses, and Severe Hypoglycemia in Patients Diagnosed With Type 2 Diabetes
Authors: Fan Baoqi , Lim Cadmon K.P. , Poon Emily W.M. , Lau Eric S.H. , Wu Hongjiang , Yang Aimin , Shi Mai , Tam Claudia H.T. , Wong Samuel Y.S. , Lee Eric Kam-Pui , Wang Maggie H.T. , Chu Natural H.S. , Ozaki Risa , Kong Alice P.S. , Chow Elaine , Ma Ronald C.W. , Luk Andrea O.Y. , Chan Juliana C.N. 
Published: April 2023

OBJECTIVE
We examined the associations of GAD antibodies (GADA) and C-peptide (CP) with insulin initiation, glycemic responses, and severe hypoglycemia in type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS
In 5,230 Chinese patients (47.6% men) with T2D (mean ± SD age: 56.5 ± 13.9 years; median diabetes duration: 6 [interquartile range 1, 12] years), enrolled consecutively in 1996–2012 and prospectively observed until 2019, we retrospectively measured fasting CP and GADA in stored serum and examined their associations with aforementioned outcomes.

RESULTS
At baseline, 28.6% (n = 1,494) had low CP (&lt;200 pmol/L) and 4.9% (n = 257) had positive GADA (GADA+). In the low-CP group, 8.0% had GADA+, and, in the GADA+ group, 46.3% had low CP. The GADA+ group had an adjusted hazard ratio (aHR) of 1.46 (95% CI 1.15–1.84, P = 0.002) for insulin initiation versus the GADA− group, while the low-CP group had an aHR of 0.88 (0.77–1.00, P = 0.051) versus the high-CP group. Following insulin initiation, the GADA+ plus low-CP group had the largest decrements in HbA1c (−1.9% at month 6; −1.5% at month 12 vs. −1% in the other three groups). The aHR of severe hypoglycemia was 1.29 (95% CI 1.10–1.52, P = 0.002) in the low-CP group and 1.38 (95% CI 1.04–1.83, P = 0.024) in the GADA+ group.

CONCLUSIONS
There is considerable heterogeneity in autoimmunity and β-cell dysfunction in T2D with GADA+ and high CP associated with early insulin initiation, while GADA+ and low CP, increased the risk of severe hypoglycemia. Extended phenotyping is warranted to increase the precision of classification and treatment in T2D.