bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell‐Type Specific miRNA Regulatory Network Responses to ABA Stress Revealed by Time Series Transcriptional Atlases in Arabidopsis
Authors: Gao Zhaoxu , Su Yanning , Jiao Guanzhong , Lou Zhiying , Chang Le , Yu Renbo , Xu Chao , Han Xue , Wang Zejia , Li Jian , Deng Xing Wang , He Hang 
Published: January 2025

AbstractIn plants, microRNAs (miRNAs) participate in complex gene regulatory networks together with the transcription factors (TFs) in response to biotic and abiotic stresses. To date, analyses of miRNAs‐induced transcriptome remodeling are at the whole plant or tissue levels. Here, Arabidopsis’s ABA‐induced single‐cell RNA‐seq (scRNA‐seq) is performed at different stages of time points–early, middle, and late. Single‐cell level primary miRNAs (pri‐miRNAs) atlas supported the rapid, dynamic, and cell‐type specific miRNA responses under ABA treatment. MiRNAs respond rapidly and prior to target gene expression dynamics, and these rapid response miRNAs are highly cell‐type specific, especially in mesophyll and vascular cells. MiRNA‐TF‐mRNA regulation modules are identified by identifying miRNA‐contained feed‐forward loops (M‐FFLs) in the regulatory network, and regulatory networks with M‐FFLs have higher co‐expression and clustering coefficient (CC) values than those without M‐FFLs, suggesting the hub role of miRNAs in regulatory networks. The cell‐type‐specific M‐FFLs are regulated by these hub miRNAs rather than TFs through sc‐RNA‐seq network analysis. MiR858a‐FBH3‐MYB module inhibited the expression of MYB63 and MYB20, which related to the formation of plant secondary wall and the production of lignin, through M‐FFL specifically in vascular. These results can provide prominent insights into miRNAs' dynamic and cell‐type‐specific roles in plant development and stress responses.
Machine Learning‐Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug–Drug Self‐Assembly
Authors: Zhang Chengyuan , Yuan Yuchuan , Xia Qiong , Wang Junjie , Xu Kangkang , Gong Zhiwei , Lou Jie , Li Gen , Wang Lu , Zhou Li , Liu Zhirui , Luo Kui , Zhou Xing 
Published: January 2025

AbstractSmall molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small molecules for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen drug combinations for self‐assembling nanomedicines, employing physiochemical parameters to predict formation via machine learning. Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) are identified as effective carriers for antineoplastic drugs, with high drug loading. Nanomedicines, PEG‐coated indomethacin/paclitaxel nanomedicine (PiPTX), and laminarin‐modified indomethacin/paclitaxel nanomedicine (LiDOX), are developed with extended circulation and active targeting functions. Indomethacin/paclitaxel nanomedicine iDOX exhibits pH‐responsive drug release in the tumor microenvironment. These nanomedicines enhance anti‐tumor effects and reduce side effects, offering a rapid approach to clinical nanomedicine development.
Synergetic Contributions of High Quenching Concentration and Tuned Square Antiprism Geometry Boosting Far‐Red Emission of Eu3+ with Near‐Unit Efficiency
Authors: Li Hong , Haider Asif Ali , Xie Zhi , Liu Conglin , Zhang Hongzhi , Jiang Hongming , Li Junpeng , Zhu Jing 
Published: January 2025

AbstractFar‐red phosphors have emerged as a desirable research hotspot owing to their critical role in promoting plant growth. Especially, Eu3+ ions typically present the 5D0→7FJ (J = 0, 1, 2, 3, 4) transitions, which overlap with the far‐red light required for plant photosynthesis. However, achieving high‐efficiency far‐red emission of Eu3+ remains challenging due to weak 5D0→7F4 transition and concentration quenching. The study constructs two anomalously efficient far‐red garnet phosphors A3Sc2C3O12 (A = Y3+, Gd3+. C = Al3+, Ga3+):Eu3+. A high‐resolution STEM measurement equipped with an aberration corrector provides the direct proofs for both the [EuO8] configuration‐dependent strong 5D0→7F4 and the origin of high quenching concentration. Excitedly, a two‐component substitution (replacing Y3+‐Al3+ with Gd3+‐Ga3+) triggers a near‐unity internal quantum efficiency (IQE = 99.01%) and high external quantum efficiency (EQE = 38.73%) in Gd3Sc2Ga3O12:60%Eu3+, resulting from the effective modulation of 5D0→7F4/7F2 transitions. A far‐red LEDs device based on Gd3Sc2Ga3O12:60%Eu3+ exhibits an output power of 113 mW at 300 mA. Subsequently, practical applications for promoting plant growth underscore the significance of these findings. This work opens a new path for the development of highly efficient far‐red phosphors via the synergistic effect of Eu3+ square antiprism configuration and high quenching concentration.
Network congestion games with player failures for charging problem of EVs via matrix approach
Authors: Liu Shuqi , Ma Lijun , Wang Jinhuan 
Published: January 2025

AbstractWith the increasing popularity of electric vehicles (EVs), the congestion problem encountered during EV charging has become a new challenge that needs to be addressed. In this paper, the congestion problem of EV charging is investigated within the framework of network congestion games. It takes into account congestion during both travelling and charging stages. Initially, for the scenario where no player fails, the EV charging problem is modeled as a network congestion game, which is proven to be a potential game. Secondly, two types of games with player failures are considered. The game with player failures on roads is verified a weighted potential game, drawing support from the semi‐tensor product (STP) of matrices. The game in which players only fail at charging stations, rather than on roads, is not a (weighted) potential game but admits at least one Nash equilibrium (NE). Thirdly, the effect of player failures on NEs is discussed, and the condition that keeps the NE of the original game unchanged is provided. Finally, the theoretical results are validated through examples.
Synthesis and Characterization of Brucine Gold Nanoparticles for Targeted Breast Cancer Therapy: Mechanistic Insights Into Apoptosis and Antioxidant Disruption in MCF‐7 Cells
Authors: Alamelu Saravanan , Venkatesan Kamalesh Balakumar , Srinivasan Manoj Kumar , Pachaiappan Pugalendhi 
Published: January 2025

ABSTRACTGlobally, breast cancer continues to be the leading type of cancer affecting women, with rising mortality rates projected by 2030. This highlights the importance of developing new, affordable treatments, like drug delivery systems that use nanoparticles. Gold nanoparticles (AuNPs), including their exceptional optical and physical attributes, make them an attractive vehicle for targeted treatment, allowing for accurate and focused delivery of medication directly to cancerous cells while reducing harmful side effect. This study focuses on the synthesis and characterization of brucine‐gold nanoparticles (BRU‐AuNPs) for targeted breast cancer therapy by evaluating their antioxidant and apoptotic mechanism. BRU‐AuNPs were synthesized and characterized (UV–Vis spectroscopy, Fourier transform infrared [FTIR], scanning electron microscopy [SEM], x‐ray diffraction [XRD], dynamic light scattering [DLS], and zeta potential) to confirm successful synthesis, size, and stability. In vitro studies were assessed using MCF‐7 breast cancer cell lines to evaluate cell cytotoxicity, antioxidant balance, reactive oxygen species (ROS) generation, mitochondrial membrane potential, apoptosis induction, cell migration, and pro‐apoptotic gene expression. Characterization results confirmed the successful synthesis of BRU‐AuNPs with an average crystal size of 85.40 nm and stable surface charge. Results demonstrated that BRU‐AuNPs reduced MCF‐7 cell viability in a dose‐dependent manner, with an IC50 value of 11.47 µg/mL. Treatment with BRU‐AuNPs altered the antioxidant balance, increased ROS generation, depolarized mitochondrial membranes, and induced apoptosis. Additionally, BRU‐AuNPs inhibited cell migration and upregulated pro‐apoptotic gene expression. The synthesized BRU‐AuNPs exhibit potential as a highly effective targeted delivery system for breast cancer treatment. Their ability to directly deliver BRU to tumor cells while reducing side effects and enhancing therapeutic efficacy underscores their promise in advancing breast cancer therapy. Further studies are warranted to explore their clinical potential and optimize therapeutic outcomes.
The Legitimacy–Commitment Paradox in Corporate Sustainability Strategy Formulation
Authors: Albertsen Rikke Rønholt 
Published: January 2025

ABSTRACTResearchers have long problematised the gap between corporations' formulated sustainability strategies and their actual contributions to sustainability. This study draws on 24 months of real‐time observations in a multinational company to explore the origins of this gap in the formulation phase of corporate sustainability (CS) strategy. The findings show that contradictory logics and processes related to (a) gaining external legitimacy and (b) mobilising internal commitment impose paradoxical demands on the formulation process. Strategy makers tackled these tensions through rhetorical ambiguity and temporal separation. However, while these paradox management strategies facilitated coping with conflicting demands and avoiding deadlocks in the formulation process, they also created a commitment vacuum that undermined implementation. This study highlights the role of the formulation phase as an overlooked origin of implementation failure. The findings nuance our understanding of defensive and proactive paradox responses and call for further examination of the unintended outcomes of paradox responses.
Small Molecule X‐ray Crystal Structures at a Crossroads
Authors: Hill Nathan D. D. , Boeré René T. 
Published: January 2025

AbstractRefinement of ‘small molecule’ crystal structures from X‐ray diffraction benefits from advances in methods derived from quantum crystallography. After outlining some pertinent principles and reasons for needed improvements in the theoretical structure model, the author′s experience in implementing Hirshfeld Atom Refinement using the NoSpherA2 option in the popular Olex2 crystallographic GUI is outlined. The method allows the placement of hydrogen atoms with accuracy comparable to neutron diffraction. Moreover, the average precisions of bonds involving light atoms is found to improve in most cases, with the degree of improvement correlating strongly with the overall quality of the diffraction data and the refinement model. A suggested workflow for HAR with NoSpherA2 is provided. A call is made for wide‐spread adoption, along with a community‐wide development of ‘standard protocols for the use of aspherical form factors in chemical crystallography’.
Current and future burden of female breast cancer in the Middle East and North Africa region using estimates from GLOBOCAN 2022
Authors: Zahwe Mariam , Bendahhou Karima , Eser Sultan , Mukherji Deborah , Fouad Heba , Fadhil Ibtihal , Soerjomataram Isabelle , Znaor Ariana 
Published: January 2025

AbstractBreast cancer is the most diagnosed female cancer and the most common cause of cancer death in women in the Middle East and North Africa (MENA) region. In this study, we aimed to describe the current patterns of breast cancer among women in the MENA region and estimate the burden for the year 2050. We used the estimates of the breast cancer incidence and mortality from the GLOBOCAN 2022 database and predicted the burden of breast cancer in 2050 according to different scenarios. With 118,200 new breast cancer cases and 41,000 deaths, breast cancer contributed to 25% of cancer incidence and almost 20% of cancer mortality among women in MENA. The highest incidence rates were in Algeria and Iraq (≥60/100,000) and the lowest rates in Saudi Arabia and Yemen (<30/100,000). The highest mortality rates were in Iraq, Syrian Arab Republic, Algeria, and Sudan (>20/100,000), and the lowest in Saudi Arabia (7.6/100,000). While the incidence rates were low compared to other world regions, the mortality rates (16.9/100,000) were higher than in any other world region except Sub‐Saharan Africa. The incidence rates for women <50 years in MENA were 5.5 times lower than in women aged ≥50 years, and lower than for women <50 years in Western countries. By 2050, the burden of breast cancer is estimated to increase to 219,000 new cases and to 88,900 deaths (86% and 117%, respectively). Scaling up cancer control to curb the rising burden alongside improved surveillance is vital to develop targeted interventions and improving outcomes.
The Resilience of Green Bonds During Market Turmoil: Implications for Investors and Policymakers
Authors: Meo Muhammad Saeed , Afshan Sahar , Zaied Younes Ben , Staniewski Marcin 
Published: January 2025

ABSTRACTDespite significant growth, green bonds comprise less than 1% of the conventional bonds market, and more research is needed to determine their role as diversifiers, hedges or safe havens. In compliance. This study examines the co‐movement between green bonds and various financial markets (stocks, commodities, digital currencies, bonds and foreign exchange) before and during COVID‐19, using daily data from 28/11/2008 to 21/3/2022 and using quantile‐based analysis. The findings based on quantile‐on‐quantile regression confirm an asymmetric/non‐linear association between green bonds and other financial markets before COVID‐19, with the association varying depending on market conditions, such as bearish, normal and bullish. During the COVID‐19 period, a robust negative correlation is identified between green bonds and other financial markets, affirming the safe‐haven role of green bonds against broader financial markets. These findings have important policy implications for investors, fund managers and policymakers. For increased diversification, investors in conventional and Islamic equities, commodities, conventional bonds, Sukuk markets, virtual and foreign currency markets can find it advantageous to include green bonds as a protection to downside risk.
Results on Existence, Uniqueness, and Stability of an Impulsive Caputo–Katugampola Hybrid FDE With p$$ p $$‐Laplacian Operator
Authors: Devi Darshana , Borah Jayanta 
Published: January 2025

ABSTRACTThe article deals with a second kind of hybrid noninstantaneous impulsive fractional differential equation with ‐Laplacian operator involving Caputo–Katugampola fractional derivatives. The rudimentary concept of this article is to establish the existence, uniqueness, Hyers–Ulam stability, and Hyers–Ulam–Rassias stability. The fixed point approach is the basis for establishing the results of solution to the considered problem. An example is also given to highlight the main findings.
Joint k‐b space diffusion‐weighted image reconstruction and apparent diffusion coefficient fitting for diffusion‐weighted turbo‐spin‐echo imaging
Authors: Dai Yan , Jia Xun , Liu Jiaen , Liao Yen‐Peng , Deng Jie 
Published: January 2025

AbstractBackgroundDiffusion‐weighted (DW) turbo‐spin‐echo (TSE) imaging offers improved geometric fidelity compared to single‐shot echo‐planar‐imaging (EPI). However, it suffers from low signal‐to‐noise ratio (SNR) and prolonged acquisition times, thereby restricting its applications in diagnosis and MRI‐guided radiotherapy (MRgRT).PurposeTo develop a joint k‐b space reconstruction algorithm for concurrent reconstruction of DW‐TSE images and the apparent diffusion coefficient (ADC) map with enhanced image quality and more accurate quantitative measurements.MethodsThe joint k‐b reconstruction model was formulated as an optimization problem subject to a self‐consistency condition comprising the exponential decay relationship between DW images and the ADC map. The objective function included a data fidelity term confirming an agreement between the reconstructed images and measured k‐space data, incorporating the mono‐exponential decay relationship between DW images and ADC map as a constraint, along with spatial regularization terms on both amplitude and phase images. The optimization problem was solved using the alternating‐direction method of multipliers (ADMM). We evaluated the performance of the joint reconstruction (JR) algorithm for DW‐TSE in a phantom study and patient studies on five brain and head/neck cancer patients. Image distortion, accuracy, and repeatability of ADC measurements were assessed and compared with those from conventional Fourier‐transformed (FFT)‐based reconstruction and magnitude‐based ADC fitting methods, as well as with the clinically used DW‐EPI technique.ResultsThe proposed joint k‐b reconstruction method demonstrated improved SNR and enhanced accuracy of ADC measurements in DW‐TSE compared to the conventional method. Additionally, JR‐DW‐TSE with fewer averages at high b‐values provided better image quality than the conventional FFT‐reconstructed DW‐TSE with full averages.ConclusionThe proposed joint k‐b reconstruction method for DW‐TSE has the potential to deliver distortion‐robust diffusion‐weighted MRI (DWI) for clinical applications, which is particularly crucial for MRgRT.
Presenting Symptoms Define Time to Diagnosis in Degenerative Cervical Myelopathy: Process Mapping From a Musculoskeletal Triage Unit in the UK
Authors: Foulds Stephanie , Henshaw Lorraine , Davies Benjamin M. 
Published: January 2025

ABSTRACTStudy DesignRetrospective cohort study.ObjectiveTackling delayed diagnosis in degenerative cervical myelopathy (DCM) is a global research priority. On average, it takes 2–5 years, leading to worse outcomes from surgery and greater disability. Many countries in the UK use interface triage units run by specialist physiotherapists that sit between primary and secondary care termed musculoskeletal services. Their role in the efficient diagnosis of DCM is unknown. The aim of this study was to map the journey of the patient in the musculoskeletal service and to establish the presenting signs and symptoms.MethodsA retrospective review of 2.5 years of clinical notes was performed in a musculoskeletal service. Process mapping was utilised to visualise the patient's journey and identify delays to diagnosis and presenting signs and symptoms.ResultsTwenty‐seven cases were reviewed. Patients spent an average of three months in the service. There was a wide variety of presenting symptoms. DCM was more often suspected if patients had both upper limb symptoms and gait disturbance or pathological reflexes. Delays occurred when patients had no gait disturbance or a normal or incomplete neurological assessment. Longest delays occurred when patients received electrophysiology tests for differential diagnosis of peripheral neuropathies. Delays were also seen with incorrect triaging of MRI results.ConclusionsWhere DCM is the principal differential diagnosis, diagnosis was faster. Incomplete examination, misinterpretation of MRI findings or delays in other investigations contributed to delays. Improved awareness and protocols of care within musculoskeletal services represent an opportunity to accelerate diagnosis in DCM.
Reliability and Validity of the Japanese Version of the Internet Gaming Disorder Scale for Children (IGDS‐C)
Authors: Ono Koki , Tokushige Makoto , Hiratani Nanami , Kaneko Kyosuke , Hamamura Toshitaka , Miyamoto Yuki , Tateno Masaru , Ito Masaya , Takano Ayumi 
Published: January 2025

ABSTRACTAimThe Internet Gaming Disorder Scale is a 9‐item screening instrument developed based on the diagnostic criteria for Internet Gaming Disorder (IGD) in the DSM‐5. This study aimed to examine the reliability and validity of the Internet Gaming Disorder Scale for children (IGDS‐C) in Japanese clinical and nonclinical populations.MethodsThe study included clinical outpatients aged 9–29 with problematic game use and nonclinical adolescents aged 12–18 who played online games at least once a week. Reliability was examined by calculating internal consistency and test–retest reliability. Validity was assessed using Spearman's correlation and Confirmatory Factor Analysis (CFA).ResultsA total of 746 participants (93 clinical, 653 nonclinical) were eligible for statistical analysis. Reliability results revealed acceptable internal consistency (Cronbach's α = 0.87) and test–retest reliability (intraclass correlation coefficient = 0.62). CFA results (Comparative Fit Index = 0.92, Tucker–Lewis Index = 0.90, root mean square error of approximation = 0.10, standardized root mean square residual = 0.05, factor loadings = 0.59–0.71) and significant correlations with the GAMES test, psychological distress, and gaming hours verified the validity of the IGDS‐C.ConclusionThe study verified the reliability and validity of the IGDS‐C in Japanese clinical and nonclinical participants, suggesting that it generally reflects the severity of IGD well.
Clinical and Electromyographic Characteristics of Pediatric Laryngeal Dyskinesia
Authors: Alobida Nasser W. , Binnasser Ameen , King Aleksandra , Isaac Andre , El‐Hakim Hamdy 
Published: January 2025

AbstractObjectiveTo report the clinical and laryngeal electromyographic (LEMG) parameters of children with laryngeal dyskinesia (LD) and its prevalence among laryngeal mobility disorder (LMD) requiring full airway examination.Study DesignRetrospective uncontrolled study.SettingTertiary pediatric center.MethodsEligible children (<17 years old) were stridulous patients suspected of LMD (16 years period). We included those diagnosed with LD according to previously described criteria by Denoyelle et al, followed up for at least 3 months, who were assessed endoscopically and LEMG. Primary outcome: LEMG scores, and the prevalence of LD in all LMD who required airway exam under anesthesia. Secondary outcomes: clinical resolution, McGill scores, and instrumental swallowing test.ResultsA total of 44 patients (<17 years) were identified. Of these, 29 were included (25 boys; median age: 9.83 months [0.42‐116.58]). LD constituted 18.58% of all patients during the study period. Asymmetry of movement and LEMG between the 2 sides was noted (the right side was more affected). Seventeen had swallowing difficulties (13 abnormal instrumental tests), and 27 snored (mean McGill score 3). The median follow up was 49.96 months (range: 5.25‐243.25). Symptoms improved in all patients, but one, by the last follow‐up date.ConclusionLD is prevalent among LMD and is mostly self‐limiting. We noted asymmetry of LEMG grades between the 2 sides of the larynx, male predominance, and functional deficits in sleep and swallowing. The diagnosis requires a complete endoscopic exam with LEMG. Conflating this entity with bilateral laryngeal paralysis has likely impacted the documented epidemiology and natural history.