Effect of olanzapine combined with art therapy on self harmony and cognitive function in patients with BD
Authors: Xu Ming , Duan Yuxi , Dai Jing 
Published: March 2023

BackgroundBipolar disorder (BD) is a mental disorder accompanied by mania and depression. Patient’s mood is sometimes high and sometimes low, and its presentation is complex and irregular. Olanzapine is a commonly used antipsychotic drug, which can improve the condition of patients with BD. However, simple drug treatment cannot achieve the desired effect. In recent years, the means of art intervention in psychological diseases has attracted much attention by enabling the patient’s body and mind in a relaxed and comfortable state through artistic activities. Therefore, it can improve the patient’s cognitive function and promote the patient’s self-harmony. Therefore, this experiment used olanzapine combined with art therapy to treat patients with BD, and observed the improvement of self-harmony and cognitive function of the patients.Subjects and Methods56 patients with BD admitted to our hospital from September 2021 to April 2022 were randomly selected and divided into experimental group (28 cases) and control group (28 cases). The patients in the control group were treated with olanzapine and basic drugs. The experimental group added the activity of appreciating famous paintings on this basis, aiming to improve the patients’ cognitive and memory abilities. After 2 months of the experiment, the self-harmonious psychological state of the patients was analyzed by observing the Self Consistency and Congruence Scale (SCCS) scores of the two groups of patients; The cognitive function of patients was analyzed by Wisconsin Card Sorting Test (WCST), Wechsler Adult Intelligence Scale (WAIS-RC), and Trail Making Test-A (TMT-A).ResultsTable 1 shows the changes of SCCS scores of the two groups of patients before and after the intervention. After the intervention, the total scores, and scores of each factor of the experimental group decreased significantly, and the scores of self-disharmony factors were significantly lower than those of the control group. For the improvement of cognitive function of the two groups of patients before and after the intervention, the scale score results showed that the WCST index values and TMT-A index values of the experimental group were significantly reduced after the intervention; All indicators of WAIS-RC increased significantly. The test results of the three types of scales in the experimental group were better than those in the control group.Table 1.Comparison of SCCS scores between the two groups before and after intervention ($ \overline{x}\pm s $)FactorGroupBefore interventionAfter interventionSelf-flexibilityExperimental group49.54±8.6545.22±7.98Control group46.97±6.7245.31±7.43Self-stereotypeExperimental group23.22±4.6518.21±3.72Control group23.43±3.6520.21±3.65Self-disharmonyExperimental group48.21±9.6542.24±9.98Control group48.97±9.7347.81±11.65Total scoreExperimental group94.27±12.7587.21±13.65Control group96.07±13.0394.50±14.21ConclusionsThis experiment intervened patients with BD through olanzapine combined with art therapy. The results show that olanzapine combined with art therapy can effectively improve the cognitive function of patients with BD and promote their self-harmony, which is conducive to improving the prognosis of patients.AcknowledgementsThe research is supported by: National social science fund project “Research on the Protection and Inheritance of Yao’s’ Ancient Legal Drum ‘Traditional Skills” (No. 21BMZ037).