bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental investigation of liquid metal droplet flow affected by a time-dependent magnetic field
Authors: Karcher Christian , Lyu Ze 
Published: May 2023

Abstract
The present study investigates experimentally the effects of a time-dependent and spatially inhomogeneous magnetic field on liquid metal droplet flow down an inclined substrate. The flow is solely excited by the electromagnetic interactions between the electrically conducting melt and the applied magnetic field. The metal droplet consists of the eutectic alloy GaInSn which is liquid at room temperature. The magnetic field is generated in the gap between two metallic disks that are equipped with a special geometric arrangement of permanent magnets and put into a measured rotation. During the experiments, a droplet of a measured volume is positioned on an electrically non-conducting substrate that is slightly inclined against the horizontal direction. Droplet and substrate are placed in between the two rotating magnetic disks. In our experiments, we record the electromagnetically excited flow of the droplet downwards onto the substrate using a high-speed camera system. Applying standard techniques of digital image processing, we measure both the displacement position and velocity of the droplet as a function of time. We observe that, depending on the rotation rate of the disks and angle of inclination, the magnetic field eventually triggers this spreading process. In more detail, by evaluating the recorded data, we find that the magnetic field excites capillary waves at the free surface of the droplet. These surface waves contribute to a redistribution of volume towards the contact line formed at the downward-facing end tip of the droplet. This mode of transport steepens the contact angle, allowing the droplet to move. Besides the fundamental aspect of this work, the present study may contribute to the electromagnetic control of both the production of metallic microfibers and metallurgic coating processes as well as to the non-contact electromagnetic flow measurement technique of Lorentz force velocimetry applied to liquid metal free-surface flows.
Hanging Topic Left Dislocations as extrasentential constituents: toward a paratactic account. Evidence from English and Spanish
Authors: Villa-García Julio 
Published: May 2023

Abstract
The paper argues for a bisentential, paratactic account of Hanging Topic Left Dislocations wherein the syntactically unconnected hanging topic phrase is the remnant of an elliptical copulative sentence which is linearly juxtaposed to the second, host sentence. This proposal represents a natural extension of Ott’s system for Clitic Left Dislocations and predicative non-restrictive nominal appositives. By assuming that the hanging topic is structurally disconnected from the host sentence, the analysis constitutes a radical departure from integrated/monosentential approaches within cartography, which analyze hanging topics as intrasentential, albeit peripheral, constituents in the left spine of the clause. Using data from English and Spanish as well as from other linguistic varieties, the paratactic approach provides a principled account of various issues facing monosentential analyses of hanging topics, including anti-connectivity, coreference with the resumptive/epithetic correlate, comma intonation/pause potential, case, insensitivity to locality constraints, islandhood, and potential presence of interjections between hanging topic and host sentence, amongst others. The account is also successful in capturing orphaned topics, which are not linked to any constituent in the sentence they occur with, alongside ‘interrogative’ and hyperdetached hanging topics.
The Standard Model and quantum state reduction from Heim’s field theory
Authors: Warmann Thomas 
Published: May 2023

Abstract
Core parts of the Standard Model are derived from B. Heim’s quantum field theory, whose poly-metric describes spacetime and matter in a unified formalism. Its non-linear eigenvalue equation transforms into the Einstein field equation in the macroscopic limit. The 6-dimensional Heim space can be determined as locally isomorphic to a SU(2) ⊗ SU(2) ⊗ U(1) ⊗ U(1) symmetry and thus to the SU(3), which allows to connect to the local gauge symmetries and boson fields of the Standard Model. The Fermion and Higgs field and their coupling are deduced from Heim’s basic equations, providing new insight into possible correlations of these fields. Furthermore, the derivation yields an additional imaginary coupling term which seems to account for quantum mechanical state reduction in the non-relativistic limit. The recently performed calculation of the mass spectrum of elementary particles in a new approach based on Heim’s theory (with average error to the data

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A New Mouse Model of Giant Axonal Neuropathy with Overt Phenotypes and Neurodegeneration Driven by Neurofilament Disorganization
Authors: Nath Banshi , Julien Jean-Pierre 
Published: May 2023

Research on pathogenic mechanisms underlying giant axonal neuropathy (GAN), a disease caused by a deficiency of gigaxonin, has been hindered by the lack of appropriate animal models exhibiting substantial symptoms and large neurofilament (NF) swellings, a hallmark of the human disease. It is well established that intermediate filament (IF) proteins are substrates for gigaxonin-mediated degradation. However, it has remained unknown to what extent NF accumulations contribute to GAN pathogenesis. Here, we report the generation of a new mouse model of GAN that is based on crossing transgenic mice overexpressing peripherin (Prph) with mice knockout forGan. The Gan−/−;TgPer mice developed early onset sensory-motor deficits along with IF accumulations made up of NF proteins and of Prph, causing swelling of spinal neurons at a young age. Abundant inclusion bodies composed of disorganized IFs were also detected in the brain of Gan−/−;TgPer mice. At 12 months of age, the Gan−/−;TgPer mice exhibited cognitive deficits as well as severe sensory and motor defects. The disease was associated with neuroinflammation and substantial loss of cortical neurons and spinal neurons. Giant axons (≥160 μm2) enlarged by disorganized IFs, a hallmark of GAN disease, were also detected in dorsal and ventral roots of the Gan−/−;TgPer mice. These results, obtained with both sexes, support the view that the disorganization of IFs can drive some neurodegenerative changes caused by gigaxonin deficiency. This new mouse model should be useful to investigate the pathogenic changes associated with GAN disease and for drug testing.SIGNIFICANCE STATEMENTResearch on pathogenic mechanism and treatment of GAN has been hampered by the lack of animal models exhibiting overt phenotypes and substantial neurofilament disorganization, a hallmark of the disease. Moreover, it remains unknown whether neurologic defects associated with gigaxonin deficiency in GAN are because of neurofilament disorganization as gigaxonin may also act on other protein substrates to mediate their degradation. This study reports the generation of a new mouse model of GAN based on overexpression of Prph in the context of targeted disruption of gigaxonin gene. The results support the view that neurofilament disorganization may contribute to neurodegenerative changes in GAN disease. The Gan−/−;TgPer mice provide a unique animal model of GAN for drug testing.
Ex situ culture of coral species Porites lobata (Scleractinia: Poritidae) and Pocillopora damicornis (Scleractinia: Pocilloporidae), Costa Rica: first assessment and implications
Authors: Marín-Moraga José A. , Chacón-Guzmán Jonathan , Méndez-Venegas Mauricio , Hernández-Mora Ronny A. , Cortés Jorge 
Published: May 2023

Introduction: Coral reefs worldwide-decline has prompted coral restoration as a viable strategy to rewild vulnerable, foundational coral species. Stony corals are now propagated by the thousands in both in-water and ex situ (land-based) coral nurseries, the latter being unexplored in Costa Rica, despite their potential benefits as a reef management tool.
Objective: To analyze the viability of ex situ culturing of the Pacific reef-building corals Porites lobata and Pocillopora damicornis at Parque Marino del Pacífico (PMP), Puntarenas, Costa Rica, aquaculture facilities. Methods: From May to October 2018 a total of 180 coral fragments were kept in an aquaculture recirculated system. Survival, growth, and fragment yield in relation to culture medium (physicochemical parameters) were recorded.
Results: Survival and growth rate varied between species and culture tanks. On average, surviving P. lobata fragments (68.89 %) placed in Tank 1 (T1) grew 216 %, while fragments placed in Tank 2 (T2) had a survival rate of 71.11 % and an increase of 277 % in live tissue area. P. damicornis fragments survival, basal and crown area percentage increase were: 71.11 %, 980 % and 366 % in T1, and 100 %, 976 % and 287 % in T2. Although fragments survival and growth were net positive, the yield in terms of culture was low, due to culture conditions in the tanks not meeting coral culture optimal requirements.
Conclusions: Survival and growth of both species varied depending on the tank in which they were placed. Survival was similar to that found in other ex situ studies and growth was similar to those reported in the wild, however culture performance in terms of yield was low. Aquaculture systems at PMP constitute a good base for the cultivation of corals, however for the culture effort to achieve maximum yield, current systems must be optimized according to the requirements of the target coral species.
Effect of hydroxylated and methylated flavonoids on cytochrome P450 activity in porcine intestinal epithelial cells
Authors: Karancsi Zita , Kovács Dóra , Csikó György , Palócz Orsolya , Jerzsele Ákos , Gálfi Péter , Farkas Orsolya 
Published: May 2023

AbstractCytochrome P450 (CYP) oxidases are among the main metabolizing enzymes that are responsible for the transformation of xenobiotics, including clinically important drugs. Their activity can be influenced by several compounds leading to decreased efficacy or increased toxicity of co-administered medicines. Flavonoids exert various beneficial effects on human and animal health; therefore they are used as food and feed supplements. However, they are also well-known for their CYP modulating potential. Since the amount of CYP enzymes is highest in the liver, interaction studies are mainly conducted in hepatocytes, however, CYP activity in the gastrointestinal tract is also remarkable. In this study, effects of apigenin (API), quercetin (QUE) and their methylated derivatives trimethylapigenin (TM-API), 3-O-methylquercetin (3M-QUE) and 3′,7-di-O-methylquercetin (3′7DM-QUE) on the CYP enzyme activity was examined in IPEC-J2 porcine intestinal epithelial cells. Potential food-drug interactions were studied using flavonoid treatment in combination with inducer and inhibitor compounds. API, TM-API, QUE and 3M-QUE significantly inhibited the CYP3A29 enzyme, while 3′7DM-QUE did not alter its activity. Enzyme inhibition has also been observed in case of some food-drug combinations. Our results support previous findings about CYP modulating effects of flavonoids and highlights the possibility of interactions when flavonoid-containing supplements are consumed during drug treatments.
A Classification Review of Hadith Research in Indonesia
Authors: Darmalaksana Wahyudin 
Published: May 2023

The abundance of hadith research demands a classification to sustain the discipline of hadith studies. This study aims to conduct a classification review on hadith research. The method used is qualitative through a literature review and employs a content analysis. The result shows some findings and discussions regarding the distribution, classification, and implication of hadith research. This study concludes that the classification of hadith research is significant for its enthusiasts to discern a position in sustainable research. Hence, this necessitates a formulation for hadith research development in the Department of Hadith Studies in Islamic higher education institutions in Indonesia.TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack//
Lessons learned from implementing a surge capacity support program for COVID-19 contact management in Ontario
Authors: Chambers Andrea , Quirk Jacquelyn , MacIntyre Elaina A. , Bodkin Andrea , Hanson Heather 
Published: May 2023

Abstract
Setting
In Ontario, local public health units (PHUs) are responsible for leading case investigations, contact tracing, and follow-up. The workforce capacity and operational requirements needed to maintain this public health strategy during the COVID-19 pandemic were unprecedented.

Intervention
Public Health Ontario’s Contact Tracing Initiative (CTI) was established to provide a centralized workforce. This program was unique in leveraging existing human resources from federal and provincial government agencies and its targeted focus on initial and follow-up phone calls to high-risk close contacts of COVID-19 cases. By setting criteria for submissions to the program, standardizing scripts, and simplifying the data management process, the CTI was able to support a high volume of calls.

Outcomes
During its 23 months of operation, the CTI was used by 33 of the 34 PHUs and supported over a million calls to high-risk close contacts. This initiative was able to meet its objectives while adapting to the changing dynamics of the pandemic and the implementation of a new COVID-19 provincial information system. Core strengths of the CTI were timeliness, volume, and efficient use of resources. The CTI was found to be useful for school exposures, providing support when public health measures were lifted, and in supporting PHU’s reallocation of resources during the vaccine roll-out.

Implications
When considering future use of this model, it is important to take note of the program strengths and limitations to ensure alignment with future needs for surge capacity support. Lessons learned from this initiative could provide practice-relevant knowledge for surge capacity planning.
Usos y funciones de los signos de puntuación en los Diez mandamientos (s. XIII)
Authors: Las Heras Calvo Miguel 
Published: May 2023

Este trabajo tiene por objetivo analizar el empleo de los signos de puntuación del texto de los Diez mandamientos (s. xiii), adscrito a la prosa didáctica medieval. La atención que ha recibido este texto por parte de los investigadores ha sido escasa; así que tras 30 años de su última edición (Franchini 1992a), retomamos este texto para poner de relieve su importancia en el ámbito de la puntuación medieval. Este estudio permitirá comprobar si sus usos se corresponden con lo que los investigadores han llamado «puntuación sintáctica» y observar cuáles son sus particularidades. Para ello se realizará un estudio sistemático de las unidades sintácticas más relevantes del texto en relación con los signos de puntuación que se emplean con ellas (punto medio [·] y guion [-]), así como con su ausencia (Ø).
Distance Traveled for Abortion at a North Carolina Tertiary Care Center Following Restrictive Legislation
Authors: Brenner Tara , Stuart Gretchen S. , Rowe Carly A. , Diener Zoe N. 
Published: May 2023

Background North Carolina enacted 5 statutes restricting abortion between 2011 and 2016. Our objective was to compare the proportion of women who traveled more than 25 miles to a Southern tertiary care center during 2 distinct time periods (2011 and 2017). Methods We conducted a time-series retrospective cohort study of women who obtained an abortion at University of North Carolina hos­pitals in 2011 and 2017. We collected data regarding residence, demographics, gestational age, indication, parity, and referral source. Our primary outcome was distance traveled from a person’s residence to the study center. Results We enrolled 399 women, 139 in 2011 and 260 in 2017. In 2011, 72% (100 of 139) traveled more than 25 miles, compared with 75% (195 of 260) in 2017. Fewer women traveled greater than 100 miles from their residence to our clinic in 2011 (20%) compared to 2017 (26%). Fewer women from neighboring states were seen in 2011 than 2017 (p = .04). Women seeking abortion in 2011 were 4 times less likely to have been referred from a freestanding abortion clinic compared with women in 2017 (9% [13 of 139] versus 37% [96 of 260]). Limitations The tertiary referral nature of our study limits generalizability. With 2 time-distinct cohorts, there may be factors that changed over the study period that remain unaccounted for. Conclusions A similar proportion of women traveled more than 25 miles for abortion before and after the legislative changes. Our finding that more women traveled greater than 100 miles to obtain an abortion in 2017 compared to 2011 highlights a key burden to abortion ac­cess in North Carolina. The increased number of women seen from freestanding abortion centers and from neighboring states following the legislative changes highlights an important geographical burden potentially associated with strict abortion restrictions.
Auxins seem promising as a tuning method for balancing sugars with acidity in grape musts from cv. Tempranillo, but not defoliation or application of magnesium to leaves
Authors: Olego Miguel Ángel , Quiroga Miguel Javier , Cuesta Lasso Mateo D. , Visconti Reluy Fernando , Garzón-Jimeno Enrique 
Published: May 2023

Global warming boosted by climate change affects grape quality, with increasing total soluble solids (TSS) content and decreasing total acidity (TA). However, current wine preferences increasingly include moderate alcohol content, higher acidity and the preservation of primary aromas reminiscent of grapes. Therefore, we hypothesised that applying phytohormones or mineral nutrients to leaves or carrying out defoliation can improve grape must properties in the face of climate warming and in accordance with current oenological trends. The effects of these three viticultural strategies were assessed independently from one another during three growing seasons in a Vitis vinifera L. cv. Tempranillo vineyard in northern Spain. Specifically, three 1-naphtaleneacetic acid (NAA) treatments, two early defoliations (ED; moderate and severe) and two foliar fertilisations with magnesium (Mg) were applied. Treatment with NAA was the most encouraging strategy for decreasing must TSS while increasing TA: it had slight effects on TSS in general and also slight effects on TA when applied close to veraison. The effects of the Mg treatments and moderate ED had null to slightly adverse effects. Finally, severe ED was clearly counter-productive. This study contributes to understanding the effects of both auxin and early defoliation treatments on grape must TSS, acidity and even yeast assimilable nitrogen (YAN) at harvest time. The favourable effects of NAA application are shown to be consistent though slight. Therefore, according to these results, the application of auxins may be an adequate choice for balancing sugars with acidity in grape musts. However, the results also suggest that more research needs to be undertaken to better characterise the effects of auxin treatments on grape must properties at harvest. In particular, different types of auxins, rates, concentrations and number of applications should be tested in the quest for more marked effects.
Regulation And Institutional Arrangement Of Village-Owned Enterprises After The Work Creation Era Applied
Authors: Gobel Rahmat Teguh Santoso , Muhtar Mohamad Hidayat , Putri Viorizza Suciani 
Published: May 2023

The management of BUMDesa is not yet optimal because many BUMDesa administrators still need to understand BUMDesa regulations and institutions. Seeing these problems, there needs to be capacity building preceded by legal reasons as a guideline for regulating BUMDesa management signs. Increasing the capacity of Village-Owned Enterprises (BUMDesa) as an organ driving the village economy can be carried out through the Job Creation Era, which has become a momentum for structuring BUMDesa regulations and institutions. The era of work creation referred to is the birth of Law Number 11 of 2020 concerning Job Creation which is now declared invalid with the presence of Government Regulation (Perpu) Number 2 of 2022 concerning Job Creation. This study uses normative legal research methods(normative legal research). The author uses this legal research because the focus is on studying literature and laws and regulations related to the object of research. The results of the research show that the Job Creation Perpu needs to be pushed into law so that it can become a legal umbrella for the establishment and management of BUMDesa institutions because, in fact, the spirit that is carried out in the Job Creation Era, namely improving the investment ecosystem and business activities, one of them through the institutional arrangement of BUM Desa.
The Effect Of Smart Tourism Technologies, Memorable Tourism Experiences, And Tourist Satisfactions On Traveller Loyalty (Study On Traveller Users Of The Tiket.Com App)
Authors: Safitri Liza Ria , Abdurrahman Agus 
Published: May 2023

The purpose of this study is to find out whether smart tourism technologies have an influence on tourist loyalty, to find out whether memorable tourism experiences have an influence on tourist loyalty, to find out whether tourist stratification has an influence on tourist loyalty, and to find out whether smart tourism technologies, memorable tourism experiences, and tourist stratification together affect loyalty tourist. The methods used in this study are descriptive types of research and quantitative approaches. The data collection technique is to distribute questionnaires to 100 respondents. The data analysis technique used is multiple regression analysis. The results obtained in this study are that there is a positive and significant influence between Smart Tourism Technologies on Tourist Loyalty of Tiket.Com App Users. There is a positive and significant impact between the Memorable Tourism Experience and the Traveller Loyalty of Tiket.Com App Users. There is a positive and significant impact between Tourist Satisfactions and Traveller Loyalty of Tiket.Com App Users. And simultaneously there is a positive and significant influence between smart tourism technologies (X1), memorable tourism experience (X2), and tourist satisfactions (X3) on the Loyalty of Tiket.Com App User Travellers. The level of relationship between the variables of smart tourism technologies (X1), memorable tourism experience (X2), and tourist satisfactions (X3) with the variable of tourist loyalty (Y) has a fairly strong level of relationship.
Extraction of Δ4 steroids from tooth dentin for LC-MS/MS
Authors: Cherney Michael , Auchus Richard 
Published: May 2023

Abstract
Tooth dentin provides a currently underutilized resource for investigating long-term steroid concentrations, and liquid chromatography tandem mass spectrometry (LC-MS/MS) provides a precise and reliable technique for measuring them. This protocol details a procedure developed for extracting Δ4 steroids from dentin, but it may be used for other solid media as well. Methanol is used to dissolve steroids from powdered dentin samples. After evaporation and reconstitution, supported liquid extraction is used to isolate dissolved Δ4 steroids for LC-MS/MS analysis. This protocol enables efficient, controlled processing of many samples, and uses readily available materials and supplies. A batch of samples can be processed in about 7 hours. This method requires access to LC-MS/MS and other lab equipment.