bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haploidentical hematopoietic stem cell transplantation as individual treatment option in pediatric patients with very high-risk sarcomas
Authors: Eichholz Thomas , Döring Michaela , Giardino Stefano , Gruhn Bernd , Seitz Christian , Flaadt Tim , Schwinger Wolfgang , Ebinger Martin , Holzer Ursula , Mezger Markus , Teltschik Heiko-Manuel , Sparber-Sauer Monika , Koscielniak Ewa , Abele Michael , Handgretinger Rupert , Lang Peter 
Published: February 2023

BackgroundPrognosis of children with primary disseminated or metastatic relapsed sarcomas remains dismal despite intensification of conventional therapies including high-dose chemotherapy. Since haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is effective in the treatment of hematological malignancies by mediating a graft versus leukemia effect, we evaluated this approach in pediatric sarcomas as well.MethodsPatients with bone Ewing sarcoma or soft tissue sarcoma who received haplo-HSCT as part of clinical trials using CD3+ or TCRα/β+ and CD19+ depletion respectively were evaluated regarding feasibility of treatment and survival.ResultsWe identified 15 patients with primary disseminated disease and 14 with metastatic relapse who were transplanted from a haploidentical donor to improve prognosis. Three-year event-free survival (EFS) was 18,1% and predominantly determined by disease relapse. Survival depended on response to pre-transplant therapy (3y-EFS of patients in complete or very good partial response: 36,4%). However, no patient with metastatic relapse could be rescued.ConclusionHaplo-HSCT for consolidation after conventional therapy seems to be of interest for some, but not for the majority of patients with high-risk pediatric sarcomas. Evaluation of its future use as basis for subsequent humoral or cellular immunotherapies is necessary.
Efficacy and safety of different radiotherapy doses in neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: A retrospective study
Authors: Xu Yuyan , Zou Haizhou , Shao Zhenyong , Zhang Xuebang , Ren XiaoLin , He Huijuan , Zhang Dahai , Du Dexi , Zou Changlin 
Published: February 2023

BackgroundThis study aims to compare the efficacy and safety of neoadjuvant chemoradiotherapy (nCRT) with different radiotherapy doses (45Gy and 50.4Gy) in patients with locally advanced rectal cancer (LARC).MethodsHerein, 120 patients with LARC were retrospectively enrolled between January 2016 and June 2021. All patients underwent two courses of induction chemotherapy (XELOX), chemoradiotherapy, and total mesorectum excision (TME). A total of 72 patients received a radiotherapy dose of 50.4 Gy, while 48 patients received a dose of 45 Gy. Surgery was then performed within 5-12 weeks following nCRT.ResultsThere was no statistically significant difference between the baseline characteristics of the two groups. The rate of good pathological response in the 50.4Gy group was 59.72% (43/72), while in the 45Gy group achieved 64.58% (31/48) (P&gt;0.05). The disease control rate (DCR) in the 50.4Gy group was 88.89% (64/72), compared to 89.58% (43/48) in the 45Gy group (P&gt;0.05). The incidence of adverse reactions for radioactive proctitis, myelosuppression, and intestinal obstruction or perforation differed significantly between the two groups (P&lt;0.05). The anal retention rate in the 50.4Gy group was significantly higher in contrast to the 45Gy group (P&lt;0.05).ConclusionsPatients receiving a radiotherapy dose of 50.4Gy have a better anal retention rate but also a higher incidence of adverse events such as radioactive proctitis, myelosuppression, and intestinal obstruction or perforation, and a comparable prognosis to patients treated with a radiotherapy dose of 45Gy.
Capsulotomy opening diameter outcomes in aphakic eyes after primary congenital cataract removal and its association
Authors: Zhao Qihui , Chang Pingjun , Zhao Yinying , Wang Dandan , Zhao Yune 
Published: February 2023

AimTo observe the change of capsulotomy opening diameter (COD) in aphakic eyes after primary congenital cataract removal and investigate its influencing factors.MethodsOcular parameters, including corneal diameter (CD), axial length (AL), anterior and posterior COD (ACOD, PCOD), and age at surgery were recorded at primary congenital cataract removal and secondary intraocular lens implantation. The concentrations of 15 kinds of cytokines in aqueous humor samples collected at the primary surgery were detected. The change (Δ) of COD between two surgeries were described, and its association was analyzed.ResultsFifty eyes from 33 patients with congenital cataract who underwent primary and secondary surgery were enrolled. The changes in ACOD and PCOD were not statistically significant on the whole. ΔACOD was positively correlated with ΔCD and the concentrations of PDGF-AA, VEGF and TGF-β1. The concentration of FGF-2 and the interval between two surgeries showed negative correlations with ΔACOD and ΔPCOD.ConclusionCOD in aphakic eyes kept changing after primary surgery. The positive correlation between ΔACOD and ΔCD manifested the enlargement of ACOD was influenced by lateral eye growth. Meanwhile, ΔACOD was also associated with cytokines, indicating postoperative inflammation promoted the ACOD constriction.
The influence of age and sex on speed–strength performance in children between 10 and 14 years of age
Authors: Warneke Konstantin , Wagner Carl Maximilian , Konrad Andreas , Kadlubowski Björn , Sander Andre , Wirth Klaus , Keiner Michael 
Published: February 2023

Introduction: Speed-strength performance is important during human movements such as jumping, sprinting, and change of direction (COD) tasks, which are a substantial part of sports practice. Sex and age seem to influence performance output in young persons; however, few studies have focused on the influence of sex and age measured via standard protocols of performance diagnostics.Method: Therefore, the aim of this study was to investigate the influence of age and sex on linear sprint (LS), COD sprint, countermovement jump (CMJ) height, squat-jump (SJ) height, and drop-jump (DJ) height performance in untrained children and adolescents via a cross-sectional analysis. This study comprised 141 untrained male and female participants 10–14 years of age.Results: The results showed the influence of age in male participants on speed-strength performance, while in female participants, age did not significantly influence performance parameters. Moderate to high correlations between sprint and jump performance (r = 0.69–0.72), sprint and COD sprint performance (r = 0.58–0.72), and jump and COD sprint performance (r = 0.56–0.58) were found.Discussion: Based on the data from this study, it appears that the growth phase of age 10–14 does not necessarily lead to improvements in athletic performance. To ensure holistic motor development, female subjects in particular should be provided with specific training interventions with a focus on strength and power.
The acute effects of whole-body vibration on motor unit recruitment and discharge properties
Authors: Lecce E. , Nuccio S. , Del Vecchio A. , Conti A. , Nicolò A. , Sacchetti M. , Felici F. , Bazzucchi I. 
Published: February 2023

Introduction: several studies have reported improved neuromuscular parameters in response to whole-body vibration (WBV). This is likely achieved by modulation of the central nervous system (CNS). Reduced recruitment threshold (RT), which is the % of Maximal Voluntary Force (%MVF) at which a given Motor Unit (MU) is recruited, may be responsible for the force/power improvements observed in several studies.Methods: 14 men (25 ± 2.3 years; BMI = 23.3 ± 1.5 kg m2 MVF: 319.82 ± 45.74 N) performed trapezoidal isometric contractions of the tibialis anterior (TA) at 35-50-70 %MVF before and after three conditions: WBV, STAND (standing posture), and CNT (no intervention). The vibration was applied through a platform for targeting the TA. High-density surface electromyography (HDsEMG) recordings and analysis were used to detect changes in the RT and Discharge Rate (DR) of the MUs.Results: Mean motor unit recruitment threshold (MURT) reached 32.04 ± 3.28 %MVF before and 31.2 ± 3.72 %MVF after WBV, with no significant differences between conditions (p &gt; 0.05). Additionally, no significant changes were found in the mean motor unit discharge rate (before WBV: 21.11 ± 2.94 pps; after WBV: 21.19 ± 2.17 pps).Discussion: The present study showed no significant changes in motor unit properties at the base of neuromuscular changes documented in previous studies. Further investigations are needed to understand motor unit responses to different vibration protocols and the chronic effect of vibration exposure on motor control strategies.
Symptom distress and suicidal ideation among Chinese ovarian cancer patients: A moderated mediation model of depression and suicide resilience
Authors: Chen Jie , Zhang Yinying , Cheng Fang , Xie Jinzhi , Zhang Keke , Hu Deying 
Published: February 2023

ObjectiveThe aim of this study was to examine whether depression mediates the relationship between symptom distress and suicidal ideation in Chinese patients with ovarian cancer, and whether this mediating effect was moderated by suicide resilience.MethodsFrom March to October 2022, this cross-sectional study was performed in a three Grade 3A hospital and an oncology specialty hospital in Wuhan, Hubei Province, China. Ultimately, 213 ovarian cancer patients completed anonymous self-report. Bootstrapping method was used for regression analysis to test the mediating and moderating effects.ResultsAmong the 213 participants, 29.58% (n = 63) exhibited significant suicidal ideation. Symptom distress was positively associated with suicidal ideation, and depression partially mediated this relationship. Suicide resilience moderated the relationship between depression and suicidal ideation. In ovarian cancer patients with low suicide resilience, the effect of symptom distress on suicidal ideation through depression was greater, while in patients with high suicide resilience, this effect was attenuated.ConclusionOur study suggests that symptom distress could be more likely to lead to suicidal ideation as depression levels increase in ovarian cancer patients. Fortunately, suicide resilience could attenuate this negative effect.
A within-person examination of the effect of mentors’ daily ostracism on protégés’ displaced aggression and in-role performance
Authors: Li Miaomiao , Wu Lunwen , Qin Yinglin 
Published: February 2023

PurposeDrawing on social information processing theory and social comparison theory, we test how mentors’ daily ostracism triggers protégés’ envy, thus leading to decreased in-role performance and increased displaced aggression.Design/methodology/approachUsing an experience sampling study across three work weeks, the study provided theoretical and empirical examinations of dynamic, within-person processes related to mentors’ ostracism.FindingsMentors’ daily ostracism triggers protégés’ envy, which mediates the effect of mentors’ daily ostracism on protégés’ displaced aggression and in-role performance. Our findings supported our hypothesis of the buffering effect of mentorship quality on the negative effect of mentors’ ostracism on protégés’ envy but did not show a significant moderating effect on the mediating effect of protégés’ emotions between mentors’ daily ostracism and protégés’ behaviors.Research limitations/implicationsOur study focused on the victims of mentors’ ostracism on a daily basis. We constructed an overarching theoretical model to investigate how, why, and when mentors’ daily ostracism leads to protégés’ emotional and behavioral variability.Practical implicationsThe study provided how to cope with ostracism and envy.Originality/valueWe discuss the theoretical implications of our findings for research on mentors’ ostracism, protégés’ emotions, and protégés’ behaviors.
The relationship between psychiatric nurses’ perceived organizational support and job burnout: Mediating role of psychological capital
Authors: Tang Yingxue , Wang Yingxuan , Zhou Haiying , Wang Juan , Zhang Rui , Lu Qinghua 
Published: February 2023

BackgroundPsychiatric nurses need to keep close contact with patients suffering from mental illness. Because of the special nature of their profession, there is an increasing incidence of job burnout among psychiatric nurses.AimThis study examined the relationship between psychiatric nurses’ perceived organizational support, job burnout, and psychological capital. It also investigated the mediating role of psychological capital in the relationship between their perceived organizational support and job burnout.MethodsA total of 916 psychiatric nurses were recruited from 6 grade-III mental facilities in Shandong Province using the stratified sampling approach. Their data were collected and examined using a general demographic data questionnaire, The Maslach Burnout Inventory, the Perceived Organizational Support Scale, and the Psychological Capital Questionnaire.ResultsThe total score of job burnout was 53.71 ± 16.37. Specifically, 73.69% of the nurses had moderate to severe emotional exhaustion, 76.75% had moderate to severe job burnout pertaining to depersonalization, and 98.80% had moderate to severe job burnout pertaining to personal accomplishment. Spearman’s correlation analysis showed that both psychological capital (r = −0.35, p &lt; 0.01) and perceived organizational support (r = −0.31, p &lt; 0.01) were adversely related to job burnout. Additionally, psychological capital somewhat mediated the relationship between perceived organizational support and job burnout. Its mediating impact accounted for 33.20% of the overall effect.ConclusionThis study’s participants had a moderate to severe level of job burnout. However, organizational support and psychological capital can be crucial in alleviating this problem among psychiatric nurses. Therefore, nursing managers and medical institutions should undertake timely and positive interventions to improve psychiatric nurses’ mental health and prevent job burnout. While exploring the impact of organizational support and psychological capital on job burnout, future studies should consider other effective influencing factors, and the relationship between the different factors should be explored in depth. This would provide a basis for developing a job burnout prevention mechanism.
Passive and active suicidal ideation in a population-based sample of older adults: Associations with polygenic risk scores of relevance for suicidal behavior
Authors: Zettergren Anna , Jonson Mattias , Mellqvist Fässberg Madeleine , Najar Jenna , Rydberg Sterner Therese , Seidu Nazib M. , Kern Silke , Blennow Kaj , Zetterberg Henrik , Skoog Ingmar , Waern Margda 
Published: February 2023

IntroductionThere are few studies investigating genetic factors related to suicidal ideation or behavior in older adult populations. Our aim was to test associations between passive and active suicidal ideation and polygenic risk scores (PRSs) for suicidality and other traits of relevance for suicidality in old age (i.e. depression, neuroticism, loneliness, Alzheimer’s disease, cognitive performance, educational attainment, and several specified vascular diseases) in a population-based sample aged 70 years and older.MethodsParticipants in the prospective H70 study in Gothenburg, Sweden, took part in a psychiatric examination that included the Paykel questions on active and passive suicidal ideation. Genotyping was performed with the Neurochip (Illumina). After quality control of the genetic data the sample included 3467 participants. PRSs for suicidality and other related traits were calculated based on summary statistics from recent GWASs of relevance. Exclusion of persons with dementia or incomplete data on suicidal ideation yielded 3019 participants, age range 70–101 years. Associations between past year suicidal ideation (any level) and selected PRSs were analysed using general estimation equation (GEE) models, adjusted for sex and age.ResultsWe observed associations between passive/active suicidal ideation and PRSs for depression (three versions), neuroticism, and general cognitive performance. After excluding individuals with current major depressive disorder (MDD), similar associations were seen with PRS for neuroticism, general cognitive performance and two PRSs for depression. No associations were found between suicidal ideation and PRSs for suicidality, loneliness, Alzheimer’s disease, educational attainment, or vascular disease.DiscussionOur results could indicate which types of genetic susceptibility that are of importance for suicidality in old age, and these findings can help to shed light on potential mechanisms that may be involved in passive and active suicidal ideation in late-life, also in those with no current MDD. However, due to the limited sample size, the results need to be interpreted with caution until replicated in larger samples.
Case report: Hilar metastasis of breast cancer: A single-center retrospective case-control study
Authors: Yang Ruohan , Jia Lin , Lv Zheng , Cui Jiuwei 
Published: February 2023

PurposeThe lungs are a common metastatic organ in breast cancer, mainly due to blood metastasis. On imaging, most metastatic lesions show a peripheral round mass in the lung, occasionally with a hilar mass as the primary manifestation, showing burr and lobulation signs. This study aimed to investigate breast cancer patient's clinical characteristics and prognosis with two different metastatic sites in the lung.MethodsWe retrospectively analyzed patients admitted to the First Hospital of Jilin University between 2016 and 2021 diagnosed with breast cancer lung metastases. Forty breast cancer patients with hilar metastases (HM) and 40 patients with peripheral lung metastases (PLM) were matched 1:1 using a pairing method. To analyze the patient's prognosis, the clinical characteristics of patients with two different metastatic sites were compared using the chi-square test, Kaplan–Meier curve, and Cox proportional hazards model.ResultsThe median follow-up time was 38 months (2–91 months). The median age of patients with HM was 56 years (25–75 years), and that of patients with PLM was 59 years (44–82 years). The median overall survival (mOS) was 27 months in the HM group and 42 months in the PLM group (p = 0.001). The results of the Cox proportional hazards model showed that the histological grade (hazard ratio = 2.741, 95% confidence interval 1.442–5.208, p = 0.002) was a prognostic factor in the HM group.ConclusionThe number of young patients in the HM group was higher than that in the PLM group, with higher Ki-67 indexes and histological grades. Most patients had mediastinal lymph node metastasis, with shorter DFI and OS and poor prognosis.
Failure to rescue following anatomical lung resection. Analysis of a prospective nationwide database
Authors: Gómez-Hernández María Teresa , Rivas Cristina , Novoa Nuria , Jiménez Marcelo F. ,   the Spanish Group of Video-assisted Thoracic Surgery (GEVATS)
Published: February 2023

BackgroundRescue failure has been described as an important factor that conditions postoperative mortality after surgical interventions. The objective of this study is to determine the incidence and main determinants of failure to rescue after anatomical lung resections.MethodsProspective multicenter study that included all patients undergoing anatomical pulmonary resection between December 2016 and March 2018 and registered in the Spanish nationwide database GEVATS. Postoperative complications were classified as minor (grades I and II) and major (grades IIIa to V) according to the Clavien-Dindo standardized classification. Patients that died after a major complication were considered rescue failure. A stepwise logistic regression model was created to identify predictors of failure to rescue.Results3,533 patients were analyzed. In total, 361 cases (10.2%) had major complications, of which 59 (16.3%) could not be rescued. The variables associated with rescue failure were: ppoDLCO% (OR, 0.98; 95% CI, 0.96–1; p = 0.067), cardiac comorbidity (OR, 2.1; 95% CI, 1.1–4; p = 0.024), extended resection (OR, 2.26; 95% CI, 0.94–5.41; p = 0.067), pneumonectomy (OR, 2.53; 95 CI, 1.07–6.03; p = 0.036) and hospital volume &lt;120 cases per year (OR, 2.53; CI 95%, 1.26–5.07; p = 0.009). The area under the curve of the ROC curve was 0.72 (95% CI: 0.64–0.79).ConclusionA significant percentage of patients who presented major complications after anatomical lung resection did not survive to discharge. Pneumonectomy and annual surgical volume are the risk factors most closely related to rescue failure. Complex thoracic surgical pathology should be concentrated in high-volume centers to obtain the best results in potentially high-risk patients.
Antioxidant Potential of Tamarillo Fruits—Chemical and Infrared Spectroscopy Analysis
Authors: Rito Miguel , Marques Joana , da Costa Ricardo M. F. , Correia Sandra , Lopes Tércia , Martin Daniel , Canhoto Jorge M. P. L. , Batista de Carvalho Luís A. E. , Marques Maria Paula M. 
Published: February 2023

Native to South America, tamarillo (Solanum betaceum Cav.) is a small tree cultivated as a fruit crop in several regions of the world. Known for its sweet and sour taste, tamarillo fruits are very nutritious due to the presence of health-beneficial components such as fiber, vitamins, and antioxidants. Despite its nutritional value, tamarillo remains poorly known in global markets. The present work aims to study the antioxidant activity of four genotypes of tamarillo. Several chemical assays were performed to assess the antioxidant components and antioxidant activity of aqueous ethanolic extracts from each genotype. Overall, the Mealhada genotype (a red cultivar) showed the most interesting results, displaying the highest amount of total phenolic, flavonoids, and anthocyanin contents, as well as higher antioxidant activity. To evaluate the composition of the extract, Fourier-transform infrared spectroscopy (FTIR) was used to characterize important components in aqueous ethanolic extracts of the fruits, having revealed the presence of high amounts of phenols (the main compounds responsible for antioxidant activity), as well as triterpenoids and polysaccharides. The present results highlight the potential nutraceutical importance of tamarillo fruits.