bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling broad‐scale patterns of elk summer resource selection in Montana using regional and population‐specific models
Authors: Ranglack Dustin H. , Proffitt Kelly M. , Canfield Jodie E. , Gude Justin A. , Rotella Jay , Garrott Robert A. 
Published: December 2022

AbstractUnderstanding animal distribution is important for management of populations and their habitats. Across the western United States, elk (Cervus canadensis) provide important ecological, cultural, and economic benefits and the sound management of their habitats is of vital importance. In western Montana, National Forest lands are managed in part to provide and protect elk habitat needs, and summer elk habitat is managed with consideration to motorized routes. We evaluated the relative importance of nutritional resources, access routes, and other landscape attributes on elk summer resource selection at multiple spatial scales, and compared resource selection among nine different southwestern Montana elk populations to determine the applicability of generalized regional models for informing habitat management recommendations. First, we developed nine population‐specific and two regional summer resource selection models. Second, we evaluated the predictive performance of each model within and among elk populations using cross‐validation scores to identify the best model. We found that in all populations nutritional resources, best represented using normalized difference vegetation index (NDVI) metrics, were the most important factors associated with elk summer resource selection. Access routes affected resource selection in all populations; however, the influence of access routes was relatively modest as compared with nutritional resources. Of the access route covariates we considered, density of all routes (i.e., routes open and closed to motorized use) explained most variation in summer elk resource selection. Validation of population‐specific resource selection models among populations revealed that in many cases model predictions extrapolated to areas outside of the development area had modest to poor predictive performance, especially as distance from the modeled population increased. Thus, caution should be used when extrapolating resource selection models based on a single study population to other populations. Regional models of resource selection predicted resource selection across populations better than population‐specific models, particularly when constructed by pooling data from multiple populations, and we recommend these types of models be used to inform regional habitat management policies. Our results suggest that managers should expand any current management paradigm for elk summer habitat that is focused on limiting access route density to also consider nutritional resources as an important component of elk summer habitat.
Rapid shifts in migration routes and breeding latitude in North American bluebirds
Authors: Sonnleitner Jared , LaZerte Stefanie E. , McKellar Ann E. , Flood Nancy J. , Reudink Matthew W. 
Published: December 2022

AbstractSpatial and temporal shifts in the migratory patterns of birds have become more frequent as climate change and habitat alteration continue to impact ecosystems and the species dependent on them. In this study, we used eBird community science data collected over ten years to examine potential changes in the migratory patterns of three North American bluebird species: eastern (Sialia sialis), western (Sialia mexicana), and mountain (Sialia currucoides) bluebirds. Community science datasets such as those provided through eBird are a valuable tool for examining population‐level processes, as such data are often costly and time‐consuming to collect through other approaches (e.g., directly tracking individuals). Using generalized additive models, we produced smoothed migration paths for all three species over each season from 2009 to 2018. We asked whether there were changes over this 10‐year period in the timing of spring and fall migration and migration speed, and the population centroids during breeding and migration. In contrast to many species that are experiencing poleward shifts in their distributions, the population centroids during the breeding period of all three bluebird species appear to have shifted southward over the past decade. Perhaps most surprisingly, we also detected strong longitudinal shifts in the population centroids during migration in eastern and western bluebirds, with both species shifting toward the center of the continent. Despite these changes in migratory routes and breeding distributions, we detected no change in the migratory timing or speed of any of the species. Our analysis indicates that bluebirds are rapidly altering the pattern of their migration, likely in response to changing environmental conditions, but not always in the direction predicted.
Azulene‐Indole Fused Polycyclic Heteroaromatics
Authors: Duan Chao , Zhang Jianwei , Cai Shali , Xiang Junjun , Yang Xiaodi , Gao Xike 
Published: December 2022

AbstractLinear polycyclic systems are promising candidates in the area of organic electronics. Herein, we present the syntheses of three azulene‐indole (AzIn) fused polycyclic heteroaromatics (PHAs),AzIn‐1,AzIn‐2andDGAzIn, which have nitrogens and nonhexagonal rings simultaneously. The chemical structures, optical and electrochemical properties of three AzIn‐based PHAs have been investigated, as well as their protonation behaviors with trifluoroacetic acid (TFA). All three AzIn‐based PHAs exhibit narrow optical band gaps with moderate to good air stability,anti‐Kasha emission and reversible stimuli‐responsiveness. Furthermore, these straightforward and simple synthetic routes would provide a new entry for constructing novel azulene‐embedded π‐conjugates, especially for the seven‐membered ring of azulene unit, wherein the regioselective transformation is not well developed.
Environmental drivers of paraglacial time duration and intensity for scree slopes dynamics in forested environments
Authors: Germain Daniel , Stabile‐Caillé Ludwig 
Published: December 2022

AbstractThe highly fissile lithology of the rockwalls and the diversity of mass‐wasting processes provide a specific character to the active talus slopes of the northern Gaspé Peninsula since deglaciation. At a regional scale, the geology of the rockwalls, the patterns and modalities of deglaciation and the evolution towards a cold temperate morphoclimatic regime in a maritime context still influence the geomorphological dynamics of scree slopes today. At a local scale, the south–north orientation of the main coastal valleys influences insolation and exposure to prevailing winds, which in turn influence the snow cover regime and the occurrence of freeze–thaw cycles. The statistical analyses carried out from the mapping of 43 talus slopes and their geometric variables allowed the identification of significant environmental factors for the characterization of the dominant geomorphic processes: snow avalanches, frost‐coasted clast flows, debris flows and rockfalls. Slope aspect appears to be a key parameter in the nature of the processes acting on the talus slopes. East‐ and north‐facing talus slopes are generally covered by a significant snowpack in winter and the dominant processes are snow avalanches and debris flows. West‐ and south‐facing talus slopes face prevailing winds and insolation and are subject to frost‐coated clast flows, the main driver for forest regression, and rockfalls. However, the evolution of scree slopes in forested environments remains extremely complex due to the multiscale components that affect their evolution in the short, medium and long term.
Genome‐wide association analysis of chilling‐tolerant germination in a new maize association mapping panel
Authors: Ma Yun , Yao Lan , Zhang Liwei , Su Aiguo , Wang Ronghuan , Song Wei , Li Zhaowei , Zhao Jiuran 
Published: December 2022

AbstractMaize is a crop that is highly susceptible to the negative effects of low temperature. Low temperature can delay seed germination and cause a decrease in seed vigor, which seriously affects seedling emergence and yield. In this study, 190 maize accessions (inbred lines) with strong germination potential at normal temperature (25°C) were selected from more than 500 accessions to construct a new association mapping panel to further investigate germination under chilling stress (5°C). We re‐sequenced the genomes of the 190 diverse accessions and obtained 4,886,919 high‐quality SNPs. We then used this data to analyze population structure, perform principal components analysis, and construct a phylogenetic tree of the new maize panel. The relative germination rate (RGR) and relative germination index (RGI) are two traits that are significantly related to chilling‐tolerant germination. Genome‐wide association analysis showed that RGR and RGI shared a major QTL, and they also shared the top SNP. There were a total of 26 significant SNPs in common. These SNPs hit directly or indirectly within 37 candidate genes. Among these 37 gene candidates, eight are homologs of genes previously reported to be related to both germination and low‐temperature stress, and another 12 genes related to low‐temperature stress or other abiotic stresses such as drought, salinity, oxidative, and high light stress. In addition, RGR and RGI had another 15 and 26 significant SNPs, respectively, which were associated with 17 and 92 candidate genes, respectively. Further qRT‐PCR analysis using 26 chilling‐tolerant and 22 chilling‐sensitive accessions implied that Zm00001eb272370, Zm00001eb272390, and Zm00001eb272400 associated with the top SNP, may play different roles during cold‐germination. Thus, our study not only established a new association mapping panel suitable for investigation of germination at low temperature but also provided valuable genetic resources for future studies to improve chilling‐tolerant maize varieties.
Comparison of antibacterial and antioxidant potentials of pure and nanoemulsified Nepeta pogonosperma essential oil
Authors: Sharifi Kimia , Sharifi Akram 
Published: December 2022

AbstractThe current study aimed to investigate the antiradical and antibacterial potential of pure and its nanoemulsified (NNE) Nepeta pogonosperma essential oil (PNE). Antimicrobial activity of the essential oil against two Gram‐positive (E. faecalis and B. cereus) and two Gram‐negative (M. catarrhalis and K. pneumonia) food‐related pathogens during 60‐day storage was investigated based on disc diffusion, minimum inhibition concentration (MIC), and minimum bactericidal concentration (MBC). The chemical compounds of Nepeta essential oil were estimated by GC/MS. The physical properties of the nanoemulsion including polydispersity index (PDI), mean particle diameter, and viscosity were also determined. 4aα,7α,7aβ‐Nepetalactone (46.31%), 1,8‐cineole (23.13%), and (Z)‐α‐bisabolene (4.01%) were the main compounds of this essential oil. The Nepeta nanoemulsion had a mean droplet diameter of 254.07 nm, PDI of 0.281, and viscosity of 0.887 cP. NNE had stability for up to 60 days. The PNE showed a higher IC50 value than NNE (p < .05). During storage, the antiradical performance of both PNE and NNE was decreased (p < .05). However, emulsification was successful to control this decreasing trend. E. faecalis was the most susceptible bacteria to PNE and NNE, while the lowest inhibition zone was obtained for K. pneumoniae. At the first time, the antibacterial effect of PNE was more than NNE. However, over time nanoemulsion became more successful in maintaining its antibacterial effect. Overall, the incorporation of Nepeta pogonosperma essential oil into a nanoemulsion system can be a promising system to maintain the bioactivity of the essential oil for a longer time.
CA2 orchestrates hippocampal network dynamics
Authors: Oliva Azahara , Fernandez‐Ruiz Antonio , Karaba Lindsay A. 
Published: December 2022

AbstractThe hippocampus is composed of various subregions: CA1, CA2, CA3, and the dentate gyrus (DG). Despite the abundant hippocampal research literature, until recently, CA2 received little attention. The development of new genetic and physiological tools allowed recent studies characterizing the unique properties and functional roles of this hippocampal subregion. Despite its small size, the cellular content of CA2 is heterogeneous at the molecular and physiological levels. CA2 has been heavily implicated in social behaviors, including social memory. More generally, the mechanisms by which the hippocampus is involved in memory include the reactivation of neuronal ensembles following experience. This process is coordinated by synchronous network events known as sharp‐wave ripples (SWRs). Recent evidence suggests that CA2 plays an important role in the generation of SWRs. The unique connectivity and physiological properties of CA2 pyramidal cells make this region a computational hub at the core of hippocampal information processing. Here, we review recent findings that support the role of CA2 in coordinating hippocampal network dynamics from a systems neuroscience perspective.
Compound Specific Radiocarbon (14C) Dating of Our Colorful Past: from Theory to Practice
Authors: Hendriks Laura , Portmann Cyril 
Published: December 2022

AbstractFor generations, humanity has preserved customs, places, objects, artistic expressions, and values – our cultural heritage. The use of color on cultural heritage objects is ubiquitous and found on artefacts from prehistoric rock art to present day contemporary artworks. The chemical identification of the colored materials used within an artwork often provides information about the work's origin. At the simplest level, a comparison of the materials present with information on their first date of discovery indicates the earliest possible period in which the colored artefact was created. More precise constraints on the date of creation can be provided by radiocarbon (14C) dating, however until today no such analysis has ever been conducted on the compounds responsible for the object's color. The analysis of natural organic dyes and pigments is challenging, as the limited sampling access, their low concentrations and presence in highly complex matrix, are all major challenges to be overcome. The separation of intermingled carbon sources is without question the most difficult problem, yet feasible with the help of compound specific radiocarbon analysis (CSRA). Here, we discuss the potential of radiocarbon dating isolated natural organic dyes and pigments and explore new routes to date cultural heritage objects.
How do we design and evaluate health system strengthening? Collaborative development of a set of health system process goals
Authors: Bertone Maria Paola , Palmer Natasha , Kruja Krista , Witter Sophie ,   HSSEC Working Group 1
Published: December 2022

AbstractStrong health systems are widely recognized as a key requirement for improving health outcomes and also for ensuring that health systems are equitable, resilient and responsive to population needs. However, the related term Health Systems Strengthening (HSS) remains unclear and contested, and this creates challenges for how HSS can be monitored and evaluated. A previous review argued for the need to rethink evaluation methods for HSS to examine systemic effects of HSS investments. In line with that recommendation, this article describes the work of the HSS Evaluation Collaborative (HSSEC) in the development of a framework and tool to guide HSS monitoring, evaluation and learning by national and global actors. It was developed based on a rapid review of the literature and iterative expert consultation, with the aim of going beyond a focus on the building blocks of health systems and on health system outputs or health outcomes to think about the features that constitute a strong health system. As a result, we developed a list of 22 health system process goals which represent desirable attributes for health systems. The health system process goals (or rather, progress towards them) are influenced by positive and negative, intended and unintended effects of HSS interventions. Finally, we illustrate how the health system process goals can be operationalised for prospective and retrospective HSS monitoring, evaluation and learning, and how they also have the potential to be used for opening a space for participatory, inclusive policy dialogue about HSS.
Below canopy evapotranspiration in four different variable retention harvesting treatments in a red pine plantation forest
Authors: Bodo Alanna V. , Parker William C. , Elliott Ken A. , Arain M. Altaf 
Published: December 2022

AbstractVariable retention harvest (VRH) is a silvicultural approach that retains differing proportions and patterns of canopy trees across a harvested area to emulate natural disturbance effects on stand structure and enhance the resilience of the regenerating stand to abiotic and biotic stresses. Four VRH treatments were applied to an 83‐year‐old red pine (PinusresinosaAit.) plantation forest in the Mixedwood Plains Ecozone of Canada that included 55% aggregate retention (55A), 55% dispersed retention (55D), 33% aggregate retention (33A), 33% dispersed retention (33D) and an unharvested control (CN). In the sixth growing season after harvest, tree stem sap flow and eddy covariance flux measurements were used to examine the impacts of VRH on the dominant components of total stand evapotranspiration (ET), i.e., canopy transpiration (TC) and water flux from the understory vegetation and soil (ETU) as well as understory and canopy water use efficiency (WUE). A positive relationship was found between harvest intensity and the growth of understory vegetation and ETU. The contribution of ETUto ET was higher in the dispersed compared to the aggregate VRH treatments. Canopy transpiration contributed 83% of ET in the CN plot and 58%, 55%, 30% and 23% in the 55D, 55A, 33A and 33D treatments, respectively. Overall, VRH treatments resulted in increased canopy WUE but little comparative effect on understory WUE. Our results suggest that the dispersed retention pattern led to higher ET and productivity than the aggregate pattern of the same retention level. Where carbon sequestration and climate change mitigation is the primary management objective, higher retention levels such as 55D might be used to favour stand level carbon storage while accepting slower rates of understory development. Our findings on the effects of VRH on productivity and WUE of the canopy and understory will help forest managers to better employ VRH as an option to meet multiple objectives and adapt forests to a warmer, more variable climate.
Extracellular histone H3 facilitates ferroptosis in sepsis through ROS/JNK pathway
Authors: Han Zhijun , Yuan Zhizhou , Shu Linfei , Li Tao , Yang Fan , Chen Lei 
Published: December 2022

AbstractIntroductionPrevious evidence realized the critical role of histone in disease control. The anti‐inflammatory function of estradiol (E2) in sepsis has been documented. We here intended to unveil the role of extracellular histone H3 in sepsis regarding cell ferroptosis and the role of E2 in a such mechanism.MethodsClinical sample, cecal ligation and puncture (CLP)‐induced animal models and lipopolysaccharides (LPS)‐induced cell models were prepared for testing relative expression of extracellular histone H3 and E2 as well as analyzing the role of extracellular histone H3 and E2 in sepsis concerning cell viability, reactive oxygen species (ROS), and ferroptosis.ResultsUnder sepsis, we found increased ferroptosis and extracellular histone H3 content, but reduced E2 concentration. Extracellular histone H3 facilitated ferroptosis of human umbilical vein endothelial cells (HUVECs) induced by LPS through activating the ROS/c‐Jun N‐terminal kinase (JNK) pathway. Moreover, E2 antagonized the effect of extracellular histone H3 on LPS‐induced HUVEC ferroptosis and sepsis injury in CLP‐induced animal models.ConclusionWe highlighted that extracellular histone H3 facilitated lipopolysaccharides‐induced HUVEC ferroptosis via activating ROS/JNK pathway, and such an effect could be antagonized by E2.
Recent advance in mesenchymal stem cells therapy for atopic dermatitis
Authors: Najera Jonathan , Hao Jijun 
Published: December 2022

AbstractMesenchymal stem cells (MSCs) are multipotent cells found in a variety of tissues in the body, including but not limited to bone marrow, adipose tissue, umbilical cord, and umbilical cord blood. Given their immunomodulatory effect and ability to be readily isolated from several tissues, they have great potential to be used as a therapeutic agent in a variety of immune‐mediated disorders. Atopic dermatitis (AD) is a persistent and relapsing immune skin condition that has recently become more common in several species such as humans, canines, equines, and felines. The use of MSCs to treat AD has piqued the great interest of researchers in recent years. In this article, we review the recent understanding of AD pathology and advances in preclinical and clinical studies of MSCs, MSCs‐derived conditional media and exosomes as therapeutic tools to treat AD.
Mechanism of β‐hairpin formation in AzoChignolin and Chignolin
Authors: Zschau Richard L. , Zacharias Martin 
Published: December 2022

AbstractAzoChignolin is a photoswitchable variant of the mini‐protein Chignolin with an azobenzene (AMPP) replacing the central loop. AzoChignolin is unfolded with AMPP in the trans‐isomer. Transition to the cis‐isomer causes β‐hairpin folding similar to Chignolin. The AzoChignolin system is excellently suited for comprehensive analysis of folding nucleation kinetics. Utilizing multiple long‐time MD simulations of AzoChignolin and Chignolin in MeOH and water, we estimated Markov models to examine folding kinetics of both peptides. We show that while AzoChignolin mimics Chignolin's structure well, the folding kinetics are quite different. Not only folding times but also intermediate states differ, particularly Chignolin is able to fold in MeOH into an α‐helical intermediate which is impossible to form in AzoChignolin. The Markov models demonstrate that AzoChignolin's kinetics are generally faster, specifically when comparing the two main microfolding processes of hydrophobic collapse and turn formation. Photoswitchable loops are used frequently to understand the kinetics of elementary protein folding nucleation. However, our results indicate that intermediates and folding kinetics may differ between natural loops and photoswitchable variants.