bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wavefront-guided PRK treatment of myopia using a refractive aberrometer
Authors: Hofmeister Elizabeth M. , Cason John B. , Murdoch Donna M. , Yau Irene W. , Wang Ying , Parizadeh Dari D. , Janakiraman Devi Priya , Kasthurirangan Sanjeev 
Published: February 2023

Purpose:
To evaluate the safety, effectiveness, and patient-reported outcomes of wavefront-guided photorefractive keratectomy (PRK) for the correction of myopic refractive errors with and without astigmatism.

Setting:
U.S. multicenter study.

Design:
Prospective, nonrandomized clinical investigation.

Methods:
334 eyes (167 patients) underwent wavefront-guided PRK with the STAR S4 IR Excimer Laser System. Patients had preoperative myopic refractive errors with sphere up to −8.00 diopters (D) and cylinder up to −4.00 D with a maximum spherical equivalent (SE) of −10.00 D. All eyes were targeted for emmetropia, and treatment plans were derived from the iDESIGN system wavefront measurements.

Results:
At 6 months, the point of refractive stability, 99.4% of eyes achieved 20/20 or better uncorrected distance visual acuity (UDVA), 92% of eyes achieved 20/16 or better UDVA, 85.5% of eyes achieved manifest refraction SE (MRSE) within 0.50 D of target, mean SE was −0.06, and less than 1% of eyes lost more than 2 lines of corrected distance visual acuity. Glare and halos occurred with similar or lower frequencies at 6 months vs preoperative. Results from the National Eye Institute Refractive Error Quality of life questionnaire showed statistically significant improvements at 6 months vs preoperative across most measures of vision-related functioning and well-being. Approximately 98% of patients reported high satisfaction with their overall vision at 6 months.

Conclusions:
Wavefront-guided PRK with the iDESIGN aberrometer was safe, effective, and predictable for the correction of low to moderate myopia with and without astigmatism and led to high patient satisfaction.
Capillary Malformation-Arteriovenous Malformation Type 2, A Report of 6 Cases and Main Differential Diagnosis
Authors: Cordisco Maria Rosa , El-Feghaly Jinia , Prezzano James C. , Lanöel Agustina , Torres Natalia , Persico Susana , Requejo Flavio , Sierre Sergio , Fiandrino María José , Luna Laura , Maccario Maria Fernanda , Brouillard Pascal , Vikkula Miikka 
Published: February 2023

Objectives:
Capillary malformation-arteriovenous malformation (CM-AVM) is a rare disorder characterized by multifocal CMs associated with AVMs. While the phenotype of CMAVM1 has been well established in the literature, there are limited published reports documenting the clinical features of CMAVM2. Our aim is to highlight this phenotype, and the distinctive features of CMAVM2 compared with CMAVM1 and hereditary hemorrhagic telangiectasia, as prompt recognition is crucial to screen for fast-flow vascular malformations, which, if left untreated, can sometimes be life-threatening.

Methods:
This is a retrospective review of cases seen at multiple tertiary care centers in the United States and Argentina.

Results and Conclusions:
We report 6 pediatric patients with CMAVM2 presenting with diffuse multifocal cutaneous CMs, telangiectases favoring the lips, perioral area and upper trunk, and Bier spots. Three patients had epistaxis. One patient had an extracranial AVM and 1 patient had Parkes Weber syndrome. EPHB4 pathogenic variants were identified in all patients. CMAVM2 remains an underrecognized condition. Genetic testing and imaging studies are recommended to guide management.
Spontaneous thrombolysis of an unruptured intracranial aneurysm with spontaneous thrombosis
Authors: Xia Junyang , Pan Haojun , Jiang Xin , Liu Peipei 
Published: February 2023

Background:
Spontaneous thrombolysis of unruptured intracranial aneurysm with spontaneous thrombosis is rare and its significance remains unclear. To date, there are no published reports of spontaneous thrombolysis prior to growth of unruptured intracranial aneurysm with spontaneous thrombosis.

Methods:
We described a 65-year-old man with a chief complaint of mild weakness and numbness in the left limbs. He had a smoking history of 20 years. Then he was diagnosed having unruptured intracranial aneurysm with spontaneous thrombosis. His cerebrovascular digital subtraction angiography conducted 30 days after his first onset revealed spontaneous thrombolysis of the unruptured intracranial aneurysm. And his following brain computed tomography scan conducted 36 days after his first onset revealed growth of the unruptured intracranial aneurysm.

Results:
The diagnosis of unruptured right fetal-type posterior cerebral artery aneurysm with spontaneous complete thrombosis was established based on the preliminary physical examination and the imaging findings. The patient underwent embolization of the aneurysm and parent artery. We followed up with the patient for 12 months after his embolization of the aneurysm and parent artery. He experienced neither aneurysm recurrence nor cerebral infarction during this period, but his were not alleviated.

Conclusion:
Spontaneous thrombolysis after spontaneous thrombosis of unruptured intracranial aneurysm is an urgent indication for isolation of the aneurysm, as it may foreshadow the growth of unruptured intracranial aneurysm.
The efficacy and safety of acupuncture and related therapies for postpartum osteitis condensans llii
Authors: Ji Haiyang , Zhang Ke , Xu Kun , Qu Yao , Shi Lechen , Zhang Tong 
Published: February 2023

Background:
Osteitis condensans illi often leads to low back pain in postpartum women. At present, physical therapy and non-steroidal anti-inflammatory drugs are often used for osteitis condensans illi. Acupuncture and its related therapies have significant clinical efficacy in the treatment of osteitis condensans illi has been reported in many studies. The purpose of this study is to evaluate the efficacy and safety of acupuncture in the treatment of osteitis condensans illi, and to provide the latest evidence for clinical application.

Methods:
We will search PubMed, Web of Science, EMBASE, Cochrane Library, China Knowledge Resource Integrated Database, Weipu Database for Chinese Technical Periodicals, SinoMed, and Wanfang Database, conference papers and grey literature. All relevant randomized controlled trial using acupuncture and related therapies for osteitis condensans illi will be included. Two reviewers will independently search and screen date. Systematic review and meta-analysis will be completed by RevMan5.3 software (Cochrane St Albans House 57-59 Haymarket, London, United Kingdom).

Results:
This study will provide comprehensive evidence of high quality of acupuncture and related therapies for osteitis condensans illi from visual analog scale, numerical rating scale, Japanese Orthopaedic Association low back pain scale, Quality of Life Scale, and adverse reactions.

Conclusion:
This systematic review and meta-analysis will provide a reliable for evaluating the efficacy and safety of acupuncture and related therapies in treatment postpartum osteitis condensans illi.
Association Between Perioperative Costs and Induction Immunosuppression in Pediatric Liver Transplant Recipients
Authors: Ewing Caroline B. , Farnan Sheila , Squires James E. , Raghu Vikram K. 
Published: February 2023

Objectives:
The objectives of this study was to describe variation in induction regimen, identify predictors of induction immunosuppression (IS) choice, and examine the impact of induction IS regimen on length of stay (LOS) and total perioperative costs in pediatric liver transplant recipients.

Methods:
We analyzed liver transplant utilization data in the Pediatric Health Information System database. Patients were divided into 3 induction IS groups: (1) steroids only, (2) T-cell depleting antibody (TDA), and (3) non-TDA. We identified predictors of induction IS regimen and examined associations between each outcome and choice of induction IS.

Results:
We analyzed 4905 liver transplant recipients (50% female, 80% under age 13 years, 42% non-Hispanic White). Most patients (3162, 64%) received steroids only induction, and about twice as many patients received a non-TDA regimen (1093, 22%) versus a TDA regimen (650, 13%). Median total perioperative costs were highest for the TDA group [$146,438 (interquartile range $113,461–$195,575)] versus the non-TDA group [$129,307 ($102,632–$173,953)] and the steroids only group ($127,049 ($98,814–$181,053)]. Compared to steroids only induction, TDA was associated with increased LOS (+2 days, P = 0.017) with no difference in cost. Non-TDA induction was associated with a decreased LOS (−3 days, P < 0.001) and increased cost (+$42,542; P < 0.001) independent of LOS.

Conclusions:
Compared to a steroids only induction IS regimen, non-TDA induction was associated with increased total perioperative costs, even after adjustments for LOS. Future work will combine cost and outcome data to provide decision-making support in pediatric liver transplant recipients.
Intraoperative assessment of bone viability through improved analysis and visualization of dynamic contrast-enhanced fluorescence imaging: technique report
Authors: Elliott Jonathan Thomas , Jiang Shudong , Henderson Eric R. , Slobogean Gerard P. , O'Hara Nathan N. , Xu Cao , Xin Jing , Han Xinyue , Christian Melanie L. , Gitajn Ida Leah 
Published: February 2023

Abstract
Bone devitalization is believed to be a critical determinant of complications such as infection or nonunion. However, intraoperative assessment of bone devitalization, particularly in open fractures and infections, remains highly subjective resulting in variation in treatment. Optical imaging tools, particularly dynamic contrast-enhanced fluorescence imaging, can provide real-time, intraoperative assessment of bone and soft tissue perfusion, which informs the tissues' ability to heal and fight infection. We describe a novel technique to apply indocyanine green–based fluorescence imaging, using a device that is frequently used in the operating room to assess skin or flap perfusion in plastic surgery, to assess bone and deep tissue perfusion in three pertinent cases: (1) a chronic infection/nonunion after a Gustilo type 3A tibia fracture (patient 1), (2) an acute Gustilo type 3C tibia open fracture with extensive degloving/soft tissue stripping (patient 2), and (3) an atrophic nonunion of the humerus (patient 3). In all three cases, fluorescence imaging (both time-specific fluorescence and maximum fluorescence) and derived kinetic maps of time-to-peak, ingress slope, and egress slope demonstrated clear spatial variation in perfusion that corresponded to the patient pathogenesis. The impact of this information on patient outcome will need to be evaluated in future clinical trials; however, these cases demonstrate in principle that optical imaging information has the potential to inform surgical practice, reduce the variation in treatment, and improve outcomes observed in these challenging patients.
Hearing Results, Quality of Life, Patient Satisfaction, and Postoperative Complications of Day-case Versus Inpatient Stapes Surgery for Otosclerosis in Adults: A Randomized Controlled Trial
Authors: Derks Laura S. M. , Borgstein Isabelle , Kamalski Digna M. A. , Thomeer Hans G. X. M. , Tange Rinze A. , Grolman Wilko , Stokroos Robert J. , Wegner Inge 
Published: February 2023

Objective:
To investigate the effect of day-case stapes surgery on hearing results, quality of life, patient satisfaction, and complications rates, compared with inpatient stapes surgery.

Study Design:
A single-center, nonblinded, randomized controlled trial in a tertiary referral center.

Methods:
One hundred twelve adult patients planned for primary or revision stapes surgery were randomly assigned to either the day-case or inpatient treatment group. The effect on hearing outcomes (primarily), hearing benefits, quality of life, patient satisfaction, postoperative complications, and causes of crossover or readmission (secondarily) were assessed using auditory evaluations, questionnaires, and patients’ charts over a follow-up period of 1 year.

Results:
Audiometric measurements and postoperative success rates were not different between the inpatient and day-case group. There were no statistically significant differences between both groups regarding the overall quality of life (QoL) (HUI3), disease-specific QoL (GHSI), change in postoperative health status (GBI), and postoperative complications rate. We found a high patient satisfaction toward the day-case approach. Six patients allocated to the inpatient group requested same-day discharge. Of the day-case patients, there was a crossover rate to inpatient care of 38% (20 patients), mainly due to postoperative nausea and vomiting (25%), vertigo (20%), or dizziness (40%).

Conclusion:
We found no significant differences in outcomes of audiometric measurements, QoL, patient satisfaction and postoperative complications following day-case, and inpatient stapes surgery. Therefore, stapes surgery in a day-case setting seems to be a feasible approach in terms of postoperative outcome, safety, and desirability when taking patient selection and surgical planning into account. Besides this, the familiarity with a day-case approach of both patient and the surgical team, will increase the acceptance and feasibility of day-case stapes surgery.
Trends in Spontaneous Cerebrospinal Fluid Leak Repairs in the United States, 2009–2018
Authors: Totten Douglas J. , Schueth Elizabeth , Saltagi Mohamad Z. , Rabbani Cyrus , Harris Alyssa Hartsell , Tressman Dani , Hohmann Samuel F. , Nelson Rick F. 
Published: February 2023

Background:
Rates of spontaneous cerebrospinal fluid leak (sCSF) repairs have increased in recent decades in line with increases in obesity rates.

Objectives:
To determine if the national rate of sCSF leak has continued to rise in recent years and to identify associated risk factors utilizing a comprehensive national database comprising most academic medical centers.

Methods:
A retrospective review from 2009 to 2018 was performed using the Vizient Clinical Database (CDB) of 105 leading academic medical centers in the United States. Patients who underwent CSF leak repair in the CDB database using ICD-9 and ICD-10 diagnostic and procedure codes. Patients with epidural hematomas over the same time frame were used as a control. National rates of craniotomy for sCSF leak repair each quarter were assessed and sCSF leak patient characteristics (age, gender, obesity, hypertension, diabetes) were calculated.

Results:
The rate of craniotomy for all sCSF leak repairs increased by 10.2% annually from 2009 to 2015 (P < 0.0001). There was no statistically significant change in the rate of epidural hematomas over the same period. The rate of lateral sCSF leak repair increased on average by 10.4% annually from 2009 (218 cases/year) to 2018 (457 cases/year) (P < 0.0001). A statistically significant increase was observed across all regions of the United States (P ≤ 0.005). sCSF leak patients had an average (standard deviation) age of 55.0 (13.2) years and 67.2% were female. Obesity was the only demographic factors that increased significantly over time. Likely due to comorbid factors, Black patients comprise a disproportionately large percentage of lateral sCSF leak repair patients.

Conclusions:
The rate of craniotomy for spontaneous CSF leaks continues to rise by approximately 10% annually.
Systematic Review of Otologic and Neurotologic Surgery Using the 3-dimensional Exoscope
Authors: Chiang Harry , Ledbetter Leila , Kaylie David M. 
Published: February 2023

Objective:
The 3D exoscope is an emerging technology that has been met with success in neurosurgery and is now increasingly used in otologic and neurotologic surgery. There is currently no consensus on its safety, efficiency, and utility, compared to the traditional microscope for these procedures. This systematic review aims to evaluate the use of the 3-dimensional (3D) exoscope for otologic and neurotologic surgery.

Databases Reviewed:
MEDLINE/PubMed, Web of Science, Scopus, and EMBASE.

Methods:
A systematic search of the databases was conducted for otologic and neurotologic surgery using the 3D exoscope. English language papers with no limit on the date of publication were considered. Inclusion criteria: full articles studying otologic or neurotologic/skull base surgery using exoscopes. Exclusion criteria: non-otologic surgery and non-neurotologic/skull base surgery, exclusive use of the traditional microscope, editorials, video reports, and letters. Two authors independently reviewed papers for inclusion; discrepancies were settled by consensus. Extracted variables included: number of patients, types of surgical procedures, operative and postoperative complications, setup and operative time, and visualization and ergonomic rating.

Results:
Six articles containing 128 surgical cases (103 exoscopic and 25 microscopic) were analyzed. Of the exoscopic cases, 21% were surgeries for chronic ear disease, 5% were cochlear implants, and 74% were lateral skull base procedures encompassing a wide variety of approaches.

Conclusion:
Based on preliminary studies, the exoscope appears to be comparable in safety, visualization, and efficiency compared to the operating microscope, with the potential for increased comfort and ease of use.
An Elusive Diagnosis: Delays in Treatment and Opportunities for Improvement in Temporal Encephalocele and CSF Leak
Authors: Curry Steven D. , McCorkle Colin E. , Hatch Jonathan L. , Casazza Geoffrey C. 
Published: February 2023

Objective:
Symptoms of temporal encephalocele or cerebrospinal fluid (CSF) leak causing middle ear effusion or otorrhea can be nonspecific and mistaken for other common diagnoses, leading to delays in diagnosis, failed treatments, and a risk of meningitis. This study sought to investigate the association between symptomatology and time to definitive surgical management.

Study Design:
Retrospective cohort.

Setting:
Single tertiary care academic medical center.

Patients:
Adults treated surgically for temporal encephalocele or CSF leak. Revision cases were excluded.

Interventions:
Chart review was performed to identify pertinent symptoms at presentation. Multivariable regression was performed to analyze the association between symptoms and time to definitive management.

Main Outcome Measures:
Otologic and related symptoms present prior to middle cranial fossa (MCF). Time between symptom onset and surgical treatment.

Results:
Thirty-four patients had symptoms present a median of 15.5 months (interquartile range, 8–35 months; range, 1 month to 12 years) prior to surgery. The most common symptoms were subjective hearing loss in the affected ear (76.5%) and aural fullness (73.5%). Otorrhea was present in 55.9%, and 42.9% had a history of otorrhea after myringotomy with or without tube insertion. Meningitis occurred in 5 patients (14.7%). Only the absence of otalgia was statistically significantly associated with decreased time between symptoms onset and surgery (P = 0.01).

Conclusions:
Encephalocele and CSF leak were most commonly associated with aural fullness and hearing loss. Medical treatment for presumed Eustachian tube dysfunction or chronic ear disease were commonly observed. Patients had symptoms for a median of almost 1 and a half years prior to surgical management.
Beliefs and perspectives on the future of oncology pharmacy—collated results of member surveys of the European Society of Oncology Pharmacy
Authors: Crul Mirjam , Meier Carolin , Meier Klaus 
Published: February 2023

Abstract

Introduction:
The European Society of Oncology Pharmacy (ESOP) has nearly 4000 members in 66 countries. Periodically, the needs and interests of the members as well as the predictions of the members for the development of the profession of oncology pharmacy are mapped by the board of the Society. The aim of these inquiries is to help focus the Societies' advocacy works, knowledge exchange, and scientific and educational programs into those areas where the members deem this most needed.

Methods:
One survey into the future of oncology pharmacy was held in 12 individual countries during a national meeting on the topic of oncology pharmacy. In this survey, the forecasts of the members were researched. A second survey was held under the full membership to identify the topics of most interest within the broader field of oncology care.

Results:
Five hundred ninety-five colleagues responded to the future of oncology pharmacy survey and 757 to the topics of interest survey. Participating respondents came from 53 individual countries. Combined, the results show that both clinical care (in multiprofessional treatment teams) and education are important areas for the Society to continue paying attention to. The other important aspect of oncology pharmacy, which includes the practical and safety aspects of compounding, remains of great interest, especially regarding technical innovations such as robotics.

Conclusion:
ESOP will remain focused on its initial aim: to support optimal treatment for patients with cancer. The globally collated data from the two surveys show that both the clinical and the practical sides of the profession deserve continuing advancement.
A qualitative exploration of the lived experiences and perceived impact of a supportive-expressive group therapy on men living with gastrointestinal cancer
Authors: Martopullo Celestina , Oberoi Devesh V. , Carlson Linda E. , Bultz Barry D. 
Published: February 2023

Abstract

Background:
This study seeks to understand the functioning of a gastrointestinal (GI) men-only Supportive-Expressive Group Therapy (SEGT) program over time by exploring (1) men's lived experiences with group process and (2) perceived group impact relevant to supportive/expressive goals.

Methods:
A convenience sample of patients with GI cancer attending an ongoing, men-only GI cancer SEGT was interviewed at 3 and 6 months from enrollment. A qualitative study design with mixed inductive and framework thematic analysis was used. Open-ended, semistructured interviews directed the exploration of group experiences over time. SEGT goals framed the inquiry toward exploring the perceived impact of the group.

Results:
Twenty-three men were interviewed at 3 months and 13 men at 6 months of intervention. Men pointed to an overall global satisfaction with group process and subjects discussed. The SEGT model provided a sex sensitive, safe, and mutually supportive outlet for expressing and normalizing participants' feelings and emotions. Three central themes emerged relevant to group experiences: (1) the role of social comparison, (2) the role of supportive-expressive exchanges, and (3) the role of the group format, composition, and facilitation. Feeling heard and validated accelerated a sense of belonging and facilitated emotional disclosure. SEGT contributed to re-evaluation of life values/goals, mitigation of existential anxiety, and mood improvement.

Conclusions:
Group participants perceived the SEGT as effective in addressing and mitigating emotional and existential concerns. Perceived benefits were consistent with SEGT goals. The findings offer groundwork for developing men-centered cancer support groups that foster emotional exploration and expressive disclosure through validation and acceptance.