bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Pembuatan Abon Ikan Lele Untuk Peningkatan Pendapatan Masyarakat Di Desa Plalangan Kec. Kalisat Kab. Jember
Authors: Widjayanti Fefi Nurdiana , Setyowati Trias 
Published: June 2023

Ikan lele banyak dibudidayakan masyarakat dan dipilih atas dasar pertimbangan waktu panen yang jauh lebih cepat jika dibandingkan dengan Ikan konsumsi lainnya. ikan ini memiliki nilai ekonomis, mudah dipelihara karena termasuk ikan budidaya yang memiliki pertumbahan cepat, bisa tumbuh dan berkembang pada kondisi lingkungan dengan kepadatan tinggi dan minum air serta tahan terhadap penyakit. Permasalahan yang ditemukan (1) belum ada produksi abon ikan lele padahal peluang bisnisnya sangat besar (2) belum mempunyaai pengetahuan tentang cara pembuatan abon ikan lele. Oleh karena itu, Metode pendekatan yang ditawarkan untuk meyelesaikan persoalan mitra maka dengan memberikan bantuan pelatihan tentang cara pembuatan abon ikan lele, adapun tahapan pelaksaan kegiatan adalah : (a) Sosialisasi program pengabdian masyarakat; (b) Persiapan prakondisi sosial, yakni penguatan kegiatan produksi abon ikan lele pada mitra (c) Pelaksanaan program dengan memberikan penyuluhan (d) pendampingan mitra (e) penyuluhan tentang kemasan produk dan labelisasi kemasan (f) pelatihan sistem pemasaran yang didukung oleh lembaga terkait yaitu Perguruan Tinggi (Fakultas Ekonomi dan Fakultas Pertanian, Universitas Muhammadiyah Jember); (g) Pemantauan, evaluasi dan pelaporan, pelatihan laporan keuangan sederhana. Luaran dari kegiatan ini antara lain publikasi artikel ilmiah di Jurnal Nasional yang sudah terakreditasi Sinta yaitu di Jurnal LPPM UM Jember dan artikel di Media Elektronik nasional Berita Bangsa, perbaikan ketrampilan pengolahan produk dan pengemasan serta pemasaran yang dikembangkan untuk meningkatkan perilaku pembelian ulang konsumen. Luaran tambahan video kegiatan.
Penggunaan Limbah Kotoran Sapi Sebagai Bahan Dasar Pembuatan Pupuk Organik Cair
Authors: Hartatik Sri , Slameto Slameto , Ubaidillah Mohammad , Dewanti Parawita , Jalil Abdul 
Published: June 2023

Desa Purwoasri kecamatan Gumukmas kabupaten Jember memiliki luas wilayah sebesar 3092,34 km2. Sebagian besar penduduk memiliki mata pencaharian sebagai petani dan peternak. Pemenuhan kebutuhan pupuk bagi petani desa Purwoasri Gumukmas sering terkendala oleh langkanya ketersediaan pupuk pada waktu diperlukan. Di sisi lain, limbah kotoran sapi menumpuk karena tidak termanfaatkan dan dapat menjadi penyebab utama polusi lingkungan. Dengan demikian upaya pemahaman dan peningkatan kemampuan petani dalam memanfaatkan limbah kotoran sapi menjadi pupuk organik melalui penyuluhan dan pelatihan merupakan satu upaya untuk menyelesaikan permasalahan yang ada di desa Purwoasri. Kegiatan pengabdian pada masyarakat ini dilakukan melalui kerja sama antara peneliti, mahasiswa KKN dan PPL kecamatan Gumukmas. Pembuatan pupuk organic cair (POC) dilakukan dengan bahan dasar kotoran sapi yang dicampur dengan bahan lainnya. Hasil pengabdian menunjukkan bahwa petani desa Wonoasri sangat antusias untuk membuat POC dari limbah kotoran sapi yang selama menumpuk di halaman. Warga selanjutnya juga menginginkan desa Purwoasri sebagai desa binaan Universitas Jember
Predicting the Risk of Mortality for Patients Diabetic with Coronavirus Disease (COVID-19): A Retrospective study
Authors: Dharma Lindarto  , Ginting Fransiscus 
Published: June 2023

Background. One of the biggest causes of mortality of patients diabetic with COVID-19 in the globe is diabetes mellitus. The study's goal was to examine the predicting the risk of mortality for patients diabetic with coronavirus disease (COVID-19).
Methods. This is a retrospective study of patients diabetic with COVID-19 on 22 June 2020 to 21 July 2021 in H. Adam Malik Hospital Medan from 22 June 2020 to 21 July 2021.
We collected all the data from electronic medical records on diabetics with SARS-CoV-2 infection, including demographic, clinical, laboratory, and radiological characteristics, treatments, complications, and clinical outcomes. All patients had throat swabs taken from their upper respiratory tracts to determine whether they had SARS-CoV-2 infection. Diagnosis of diabetes mellitus used ADA criteria.
Results: There were 163 diabetic patients with COVID-19, consisting of mild (0%), moderate (39.8%), severe (44.2%), and critical (16.5%), and the most comorbid disease is hypertension. There was a significant age difference, length of stay, blood routine, and certain inflammatory markers between patients Diabetic with COVID-19 discharged from the hospital and died (all, p<0.05). The predicted death of patients diabetic with COVID-19 was D-dimer (OR: 4.069; p=0.008*;95% C.I: 1.43-11.55) and dexamethasone use (OR:4.769; p=0.007*; C.I: 1.54-14.71).
Conclusion. The use of dexamethasone and the increase of D-dimer values increase mortality predictions in treating diabetic patients with COVID-19 in hospitals. To prevent these harms, the management of inpatients diabetic with COVID-19 must be with good glucose consideration and monitoring.
User Satisfaction Analysis of E-Samsat SUMUT Application Using End User Computing Satisfaction (EUCS) Approach
Authors: Naufal M Farid , Utomo Rio Guntur , Achmad Kusuma Adi 
Published: June 2023

Technological developments have continued to develop until now and the community has even made it a necessity, one of which is the motorized vehicle tax payment processing service, where payments can be made via e-banking or a predetermined Bank ATM. Because of this, users believe that there is little to no difference between traditional Samsat and E-Samsat, the user returns to the Samsat Office to obtain validation of vehicle registration certificates (STNK). User satisfaction is formulating user satisfaction and comparing expectations and reality as follows: if expectations reality then very satisfied, if expectations = reality then satisfied and If expectations reality then not satisfied. The purpose of this study is to find out what factors influence user satisfaction in the North Sumatra E-Samsat application and recommendations to application developers so that user satisfaction does not decrease. This study uses quantitative methodology. Quantitative is a research method in which data collection techniques are carried out through surveys and questionnaire instruments and data analysis is carried out statistically. This study will use the End User Computing Satisfaction method, the EUCS method was chosen because it has 5 variables of content, accuracy, format, ease of use, and timeliness to measure factors that influence user satisfaction from information systems. The results of the discussion from this study using the EUCS method each variable get a score of 4 (satisfied) out of 5 total scores. But it's not perfect yet, so some improvements are needed to further increase user satisfaction.
Counting Bacterial Colony and Reducing noise on Low-Quality Image Using Modified Perona-Malik Diffusion Filter with Sobel Mask Fractional Order
Authors: Hamdani Ibnu Mansyur , Anam Syaiful , Shofianah Nur , Bustamin Syamsumar 
Published: June 2023

In the field of microbiology, the counting of bacterial colonies is fundamental and mandatory. This is done to estimate the number of bacterial cells in every 1 milliliter or gram of sample. The counting takes a long time and is tedious, so it requires an accurate and fast counting method. The image quality used is very low and contains noise. Therefore, a preprocessing method is needed to reduce the noise. The Perona-Malik filter method is known to be able to remove noise well. However, it is difficult to determine the appropriate gradient threshold parameter ( ) for each different image. To find the appropriate value of , the original Sobel Mask method and Sobel Mask Fractional-Order are used to estimate the value of . The experimental results show the results of noise reduction using PMD with a value of from the original Sobel Mask and Sobel Mask Fractional-Order. The results of the accuracy of determining the value of k with the Sobel Mask Fractional-Order (α=1.0) show higher results based on the F-Measure values for samples 1, 2, and 3 respectively 97%, 98%, and 90%.
Activation of aldehyde dehydrogenase-2 improves ischemic random skin flap survival in rats
Authors: Zhou Taotao , Wang Xibin , Wang Kaitao , Lin Yi , Meng Zhefeng , Lan Qicheng , Jiang Zhikai , Chen Jianpeng , Lin Yuting , Liu Xuao , Lin Hang , Wu Shijie , Lin Dingsheng 
Published: June 2023

ObjectiveRandom skin flaps have many applications in plastic and reconstructive surgeries. However, distal flap necrosis restricts wider clinical utility. Mitophagy, a vital form of autophagy for damaged mitochondria, is excessively activated in flap ischemia/reperfusion (I/R) injury, thus inducing cell death. Aldehyde dehydrogenase-2 (ALDH2), an allosteric tetrameric enzyme, plays an important role in regulating mitophagy. We explored whether ALDH2 activated by N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide (Alda-1) could reduce the risk of ischemic random skin flap necrosis, and the possible mechanism of action.MethodsModified McFarlane flap models were established in 36 male Sprague-Dawley rats assigned randomly to three groups: a low-dose Alda-1 group (10 mg/kg/day), a high-dose Alda-1 group (20 mg/kg/day) and a control group. The percentage surviving skin flap area, neutrophil density and microvessel density (MVD) were evaluated on day 7. Oxidative stress was quantitated by measuring the superoxide dismutase (SOD) and malondialdehyde (MDA) levels. Blood perfusion and skin flap angiogenesis were assessed via laser Doppler flow imaging and lead oxide-gelatin angiography, respectively. The expression levels of inflammatory cytokines (IL-1β, IL-6, and TNF-α), vascular endothelial growth factor (VEGF), ALDH2, PTEN-induced kinase 1 (PINK1), and E3 ubiquitin ligase (Parkin) were immunohistochemically detected. Indicators of mitophagy such as Beclin-1, p62, and microtubule-associated protein light chain 3 (LC3) were evaluated by immunofluorescence.ResultsAlda-1 significantly enhanced the survival area of random skin flaps. The SOD activity increased and the MDA level decreased, suggesting that Alda-1 reduced oxidative stress. ALDH2 was upregulated, and mitophagy-related proteins (PINK1, Parkin, Beclin-1, p62, and LC3) were downregulated, indicating that ALDH2 inhibited mitophagy through the PINK1/Parkin signaling pathway. Treatment with Alda-1 reduced neutrophil infiltration and expressions of inflammatory cytokines. Alda-1 significantly upregulated VEGF expression, increased the MVD, promoted angiogenesis, and enhanced blood perfusion.ConclusionALDH2 activation can effectively enhance random skin flap viability via inhibiting PINK1/Parkin-dependent mitophagy. Moreover, enhancement of ALDH2 activity also exerts anti-inflammatory and angiogenic properties.
A novel training program: laparoscopic versus robotic-assisted low anterior resection for rectal cancer can be trained simultaneously
Authors: Wang Yanlei , Wen Dongpeng , Zhang Cheng , Wang Zhikai , Zhang Jiancheng 
Published: June 2023

BackgroundCurrent expectations are that surgeons should be technically proficient in minimally invasive low anterior resection (LAR)—both laparoscopic and robotic-assisted surgery. However, methods to effectively train surgeons for both approaches are under-explored. We aimed to compare two different training programs for minimally invasive LAR, focusing on the learning curve and perioperative outcomes of two trainee surgeons.MethodsWe reviewed 272 consecutive patients undergoing laparoscopic or robotic LAR by surgeons A and B, who were novices in conducting minimally invasive colorectal surgery. Surgeon A was trained by first operating on 80 cases by laparoscopy and then 56 cases by robotic-assisted surgery. Surgeon B was trained by simultaneously performing 80 cases by laparoscopy and 56 by robotic-assisted surgery. The cumulative sum (CUSUM) method was used to evaluate the learning curves of operative time and surgical failure.ResultsFor laparoscopic surgery, the CUSUM plots showed a longer learning process for surgeon A than surgeon B (47 vs. 32 cases) for operative time, but a similar trend in surgical failure (23 vs. 19 cases). For robotic surgery, the plots of the two surgeons showed similar trends for both operative times (23 vs. 25 cases) and surgical failure (17 vs. 19 cases). Therefore, the learning curves of surgeons A and B were respectively divided into two phases at the 47th and 32nd cases for laparoscopic surgery and at the 23rd and 25th cases for robotic surgery. The clinicopathological outcomes of the two surgeons were similar in each phase of the learning curve for each surgery.ConclusionsFor surgeons with rich experience in open colorectal resections, simultaneous training for laparoscopic and robotic-assisted LAR of rectal cancer is safe, effective, and associated with accelerated learning curves.
Seasonality and geographical distribution of Kawasaki disease among Black children in the Southeast United States
Authors: Padilla Luz A. , Idigo Adeniyi J. , Maxwell Kathryn , Lau Yung , Wiener Howard W. , Shrestha Sadeep 
Published: June 2023

IntroductionKawasaki Disease (KD) is a leading cause of pediatric acquired heart disease in the United States, affecting up to 7,000 children annually. Seasonal variation, an epidemiological characteristic of KD, has previously been reported predominantly among Asian children; however, little is known about the epidemiology and seasonality of KD of Black children within the U.S.MethodsElectronic medical records were abstracted from 529 hospitalized KD patients admitted to a single tertiary center in Alabama between 2005 and 2019. Medical charts were reviewed to confirm KD diagnosis following American Heart Association criteria. Cases were stratified by the month of diagnosis date to assess seasonality, and statewide distribution of incidence is reported at county level using geographical spatial analysis. Comparisons were performed between Black patients and White patients with KD.ResultsThe average number of KD cases per year was 35. Approximately, 60% were males and 44% were White children (N = 234), 45% were Black children (N = 240) and 11% were other races (N = 55). Black children were younger than White children at KD admission (median age 32 vs. 41 months respectively, p = 0.02). Overall, the highest rates of cases occurred between January and April. When stratifying by race, cases started to rise in December among White children with the highest rates between February and April with a peak in March. Among Black children cases were high during the winter season (January–April) with a peak in April. Similarly high rates also occurred in June, July and November. There were no differences in geographical distribution of cases by race.ConclusionKD incidence among White children in Alabama follows a seasonal cycle similar to other regions in the U.S. However, sustained incidence and additional peaks outside of the usual KD seasonality were seen among Black children with KD. Further studies are needed to investigate differential triggers between races.
Case report: Minimally invasive removal of a dislodged thoracoamniotic shunt with an integral cystoscope in a preterm infant
Authors: Zhu Lichao , Wang Yanze , Song Honghao , Wang Xiaoqing , Zhang Mingang , Guo Feng 
Published: June 2023

IntroductionFetal pleural effusion is a rare condition that is associated with significant mortality. Although the insertion of fetal thoracoamniotic shunts can improve perinatal outcomes, there are several associated complications, such as intrathoracic dislodgement of the shunts. The optimal neonatal treatment for retained shunts remains uncertain.Case DescriptionA male infant was born at 32 weeks of gestation. He had antenatal hydrothorax that was detected at 27 weeks of gestation and was managed by intrauterine thoracoamniotic shunting. However, the shunt catheter dislodged into the fetal chest, which caused reaccumulated pleural effusion and respiratory distress requiring ventilatory support after birth. After the patient’s condition stabilized, minimally invasive removal of the retained catheter was performed on day 17 of life using an integral pediatric cystoscope via a 3-mm thoracic incision. The procedure took approximately 5 min. The postoperative course was uneventful, and the patient, who was discharged 39 days postnatally, is thriving at the 6-month follow-up.ConclusionsWe present a novel and effective approach to the management of an intrathoracic shunt using an integral cystoscope. This approach may offer a valuable alternative to traditional thoracoscopy in the neonatal period.
Cancer-associated fibroblast infiltration in osteosarcoma: the discrepancy in subtypes pathways and immunosuppression
Authors: Zhihao Zhang , Cheng Ju , Xiaoshuang Zuo , Yangguang Ma , Tingyu Wu , Yongyong Yang , Zhou Yao , Jie Zhou , Tao Zhang , Xueyu Hu , Zhe Wang 
Published: June 2023

Introduction: Osteosarcoma (OS), the primary malignant bone tumor, has a low survival rate for recurrent patients. Latest reports indicated that cancer-associated fibroblasts (CAFs) were the main component of tumor microenvironment, and would generate a variable role in the progression of tumors. However, the role of CAFs is still few known in osteosarcoma.Methods: The processed RNA-seq data and the corresponding clinical and molecular information were retrieved from the Cancer Genome Atlas Program (TCGA) database and processed data of tumor tissue was obtained from Gene Expression Omnibus (GEO) database. Xcell method was used in data processing, and Gene set variation analysis (GSVA) was used to calculates enrichment scores. Nomogram was constructed to evaluate prognostic power of the predictive model. And the construction of risk scores and assessment of prognostic predictive were based on the LASSO model.Results: This study classified Cancer Genome Atlas (TCGA) cohort into high and low CAFs infiltrate phenotype with different CAFs infiltration enrichment scores. Then TOP 9 genes were screened as prognostic signatures among 2,488 differentially expressed genes between the two groups. Key prognostic molecules were CGREF1, CORT and RHBDL2 and the risk score formula is: Risk-score = CGREF1*0.004 + CORT*0.004 + RHBDL2*0.002. The signatures were validated to be independent prognostic factors to predict tumor prognosis with single-factor COX and multi-factor COX regression analyses and Norton chart. The risk score expression of risk score model genes could predict the drug resistance, and significant differences could be found between the high and low scoring groups for 17-AAG, AZD6244, PD-0325901 and Sorafenib.Discussion: To sum up, this article validated the prediction role of CAF infiltration in the prognosis of OS, which might shed light on the treatment of OS.
Relationships between anthropometric and body composition characteristics and age in Polish women over 60 as affected by their socioeconomic and health status and physical activity levels
Authors: Podstawski Robert , Omelan Aneta , Borysławski Krzysztof , Wąsik Jacek 
Published: June 2023

Background: Little is known about changes in anthropometric and body composition (A&amp;BC) characteristics during the aging process. Research indicates that body composition can be linked with socioeconomic status (SES), health status (HS), and physical activity (PA) levels.Aim: The aim of this study was to evaluate age-related changes in A&amp;BC characteristics in female seniors aged 60+ in view of their SES, HS, and PA levels.Methods: The survey was conducted in November and December 2022 on a total of 661 female seniors. A questionnaire survey was conducted to obtain information about the participants’ socioeconomic status (chronic diseases, health status, marital status, membership in social organizations, financial status, place of residence, education). The respondents’ PA levels were assessed with the International Physical Activity Questionnaire (IPAQ), and their A&amp;BC characteristics were determined in a bioelectrical impedance analysis with the InBody 270 body composition analyzer. The relationships between A&amp;BC characteristics and age were evaluated based on the values of the Pearson correlation coefficient (r).Results: The mean values of Percent Body Fat (PBF), Body Mass Index (BMI), and the waist-hip ratio (WHR) were relatively high (37.2%, 28.5 kg/m2, and 0.8, respectively) and indicative of overweight and gynoid obesity. A higher number of significant negative correlations between A&amp;BC characteristics and age were observed in seniors with lower values of SES, HS, and PA, which points to more rapid involutional changes in this group of respondents. A segmental analysis also revealed significantly lower values of fat-free mass (FFM) and body fat mass (BFM) (both indicators were calculated in percentage and kg), in particular in the upper limbs, in women with lower SES, HS, and PA levels.Conclusion: Environmental factors, including biological, physiological, environmental, psychological, behavioral, and social factors, are significantly associated with aging in women. Age-related changes in A&amp;BC characteristics tend to proceed more rapidly in female seniors with low values of SES and HE and insufficient PA levels.
Single fibre cytoarchitecture in ventilator-induced diaphragm dysfunction (VIDD) assessed by quantitative morphometry second harmonic generation imaging: Positive effects of BGP-15 chaperone co-inducer and VBP-15 dissociative corticosteroid treatment
Authors: Mnuskina Sofia , Bauer Julian , Wirth-Hücking Anette , Schneidereit Dominik , Nübler Stefanie , Ritter Paul , Cacciani Nicola , Li Meishan , Larsson Lars , Friedrich Oliver 
Published: June 2023

Ventilator-induced diaphragm dysfunction (VIDD) is a common sequela of intensive care unit (ICU) treatment requiring mechanical ventilation (MV) and neuromuscular blockade (NMBA). It is characterised by diaphragm weakness, prolonged respirator weaning and adverse outcomes. Dissociative glucocorticoids (e.g., vamorolone, VBP-15) and chaperone co-inducers (e.g., BGP-15) previously showed positive effects in an ICU-rat model. In limb muscle critical illness myopathy, preferential myosin loss prevails, while myofibrillar protein post-translational modifications are more dominant in VIDD. It is not known whether the marked decline in specific force (force normalised to cross-sectional area) is a pure consequence of altered contractility signaling or whether diaphragm weakness also has a structural correlate through sterical remodeling of myofibrillar cytoarchitecture, how quickly it develops, and to which extent VBP-15 or BGP-15 may specifically recover myofibrillar geometry. To address these questions, we performed label-free multiphoton Second Harmonic Generation (SHG) imaging followed by quantitative morphometry in single diaphragm muscle fibres from healthy rats subjected to five or 10 days of MV + NMBA to simulate ICU treatment without underlying confounding pathology (like sepsis). Rats received daily treatment of either Prednisolone, VBP-15, BGP-15 or none. Myosin-II SHG signal intensities, fibre diameters (FD) as well as the parameters of myofibrillar angular parallelism (cosine angle sum, CAS) and in-register of adjacent myofibrils (Vernier density, VD) were computed from SHG images. ICU treatment caused a decline in FD at day 10 as well as a significant decline in CAS and VD from day 5. Vamorolone effectively recovered FD at day 10, while BGP-15 was more effective at day 5. BGP-15 was more effective than VBP-15 in recovering CAS at day 10 although not to control levels. In-register VD levels were restored at day 10 by both compounds. Our study is the first to provide quantitative insights into VIDD-related myofibrillar remodeling unravelled by SHG imaging, suggesting that both VBP-15 and BGP-15 can effectively ameliorate the structure-related dysfunction in VIDD.