bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the effect of Helicobacter pylori cagPAI variety on gene expression pattern related to gastric cancer
Authors: Ahmadzadeh Alireza , Rashidi Mohsen , Mohsenifar Zhaleh , Faeghi Fariborz , Rezaei-Tavirani Mostafa , Ahmadi Nayebali , Zali Mohammad Reza , Alebouyeh Masoud , feizi Mehdi , Ahmadzadeh Zobayde 
Published: March 2023

Abstract

Objectives
We aimed to determine possible association between heterogeneity of Helicobacter pylori cytotoxin-associated gene pathogenicity island and gene expression profiles in patients with distinct histopathological changes.

Methods
Gastric biopsies were obtained from seventy five patients. Microbiological and pathological examinations were done and intactness of Helicobacter pylori cagPAI was determined by PCR using 11 pairs of primers flanking cagζ-cagA regions and cagPAI empty site. Alterations at mRNA levels of eight genes were investigated by real-time PCR and their association with cagPAI intactness and histopathological changes examined statistically.

Results
A larger proportion of cagPAI positive strains colonized patients with SAG (52.4%), followed by CG (33.3%), and IM (14.3%). Intact cagPAI was found in 87.5% of the strains obtained from patients with SAG, while significantly lower frequency was detected among those with CG (12.5%) and IM (0%). No significant difference was found among the studied histological groups and fold changes in gene expression of gastric biopsies of Helicobacter pylori infected patients with distinct cagPAI status. However, in each histological group, the strains with more complete gene cluster induced (ErbB2, CCNE1, CTNNB1, and MMP7 in SAG and IM groups) or reduced (TP53, in CG group) expression of the GC associated genes in relatively higher levels. APC, TP53 and E-cadherin were down-regulated in patients with SAG and IM compared with CG patients, irrespective to the status of cagPAI integrity.

Conclusions

Helicobacter pylori strains that carry more complete cagPAI segment could induce remarkably higher levels of mRNA changes of GC associated genes in all histopathological groups.
The different effects of the ideal L2 self and intrinsic motivation on reading performance via engagement among young Chinese second-language learners
Authors: Zhu Xinhua , Chan Shui Duen , Yao Yuan , Zhu Siyu 
Published: March 2023

Abstract
Although motivational variables have been extensively examined in the context of English as a second/foreign language (ESL/EFL), they have received little attention when learning Chinese as a second language (CSL), especially among elementary school students in lower grades. Considering the significant impact of psychological variables on language learning and the dilemma of Chinese reading for non-Chinese speaking (NCS) students from Hong Kong, this study examined the structural relationship between the ideal L2 self and intrinsic motivation, as well as their impacts on the learning engagement and reading performance of 475 Hong Kong first-grade NCS students. Two findings were noteworthy: (1) under the simultaneous consideration of the above-mentioned variables, intrinsic motivation affects learning engagement and Chinese reading performance more than the ideal self; (2) the indirect effects of intrinsic motivation on reading performance through learning engagement are more significant than its direct effect on reading performance. The implications of the findings are discussed.
Angry lions and scared neighbors: Complex demonstrations in sign language role shift at the sign-gesture interface
Authors: Steinbach Markus 
Published: March 2023

Abstract
Sign languages make use of the full expressive power of the visual-gestural modality to report the utterances and/or actions of another person. A signer can shift into the perspective of one or more persons and reproduce the utterances or actions from the perspective of these persons. This modality-specific device of utterance and action report is called role shift or constructed action. Especially in sign language narration, role shift is a productive and expressive means that can be used to demonstrate linguistic and non-linguistic actions. Recent developments in sign language linguistics put forth new formal semantic analyses of role shift at the interface between sign language and gesture, integrating insights from classical cognitive and formal analyses of quotation, demonstration and perspective/context shift in spoken and sign languages. In this article, I build on recent accounts of role shift as a modality-specific device of demonstration and show that a modified version of this theory even accounts for cases of complex demonstrations including hybrid demonstrations, multiple demonstrations and demonstrations involving a complex interaction of gestural and linguistic components.
Mormoopid bats from Brazil: updates on the geographic distribution of three species and their echolocation calls
Authors: Falcão Fábio , Pavan Ana Carolina 
Published: March 2023

Abstract
Mormoopids are a small group of insectivorous bats largely distributed from the southwestern United States throughout Central and South America. They occupy a wide variety of habitats, and in Brazil have usually been associated with habitats in the Amazon, Cerrado, or Caatinga biomes. Nevertheless, most of the information compiled so far to infer their distributional limits is based on roosting colonies occasionally found in caves or on inventories using bat mist netting, which is known to be an ineffective method for capturing aerial insectivorous bats. In this contribution, we present new occurrence records of mormoopid bats based on acoustic surveys in the Caatinga and Cerrado biomes and make an extensive literature review to provide an up-to-date distribution of these bats in Brazil. We additionally describe important parameters of the echolocation calls of mormoopids across the geographical scope of our study, contrasting our data with published information to provide a better overview of the intraspecific acoustic variation of these bat species. Our acoustic data reveal a larger area of occurrence of mormoopids in Brazil than previously known, confirming new records for two states.
Radiomics model using preoperative computed tomography angiography images to differentiate new from old emboli of acute lower limb arterial embolism
Authors: Liu Rong , Yang Junlin , Zhang Wei , Li Xiaobo , Shi Dai , Cai Wu , Zhang Yue , Fan Guohua , Li Chenglong , Jiang Zhen 
Published: March 2023

Abstract
Our purpose was to devise a radiomics model using preoperative computed tomography angiography (CTA) images to differentiate new from old emboli of acute lower limb arterial embolism. 57 patients (95 regions of interest; training set: n = 57; internal validation set: n = 38) with femoral popliteal acute lower limb arterial embolism confirmed by pathology and with preoperative CTA images were retrospectively analyzed. We selected the best prediction model according to the model performance tested by area under the curve (AUC) analysis across 1,000 iterations of prediction from three most common machine learning methods: support vector machine, feed-forward neural network (FNN), and random forest, through several steps of feature selection. Then, the selected best model was also validated in an external validation dataset (n = 24). The established radiomics signature had good predictive efficacy. FNN exhibited the best model performance on the training and validation groups: its AUC value was 0.960 (95% CI, 0.899–1). The accuracy of this model was 89.5%, and its sensitivity and specificity were 0.938 and 0.864, respectively. The AUC of external validation dataset was 0.793. Our radiomics model based on preoperative CTA images is valuable. The radiomics approach of preoperative CTA to differentiate new emboli from old is feasible.
From netrin‐1‐targeted SPECT/CT to internal radiotherapy for management of advanced solid tumors
Authors: Kryza David , Wischhusen Jennifer , Richaud Mathieu , Hervieu Maëva , Sidi Boumedine Jacqueline , Delcros Jean‐Guy , Besse Sophie , Baudier Thomas , Laval Pierre‐Alexandre , Breusa Silvia , Boutault Erwan , Clermidy Hugo , Rama Nicolas , Ducarouge Benjamin , Devouassoux‐Shisheboran Mojgan , Chezal Jean‐Michel , Giraudet Anne‐Laure , Walter Thomas , Mehlen Patrick , Sarrut David , Gibert Benjamin 
Published: March 2023

AbstractTargeted radionuclide therapy is a revolutionary tool for the treatment of highly spread metastatic cancers. Most current approaches rely on the use of vectors to deliver radionuclides to tumor cells, targeting membrane‐bound cancer‐specific moieties. Here, we report the embryonic navigation cue netrin‐1 as an unanticipated target for vectorized radiotherapy. While netrin‐1, known to be re‐expressed in tumoral cells to promote cancer progression, is usually characterized as a diffusible ligand, we demonstrate here that netrin‐1 is actually poorly diffusible and bound to the extracellular matrix. A therapeutic anti‐netrin‐1 monoclonal antibody (NP137) has been preclinically developed and was tested in various clinical trials showing an excellent safety profile. In order to provide a companion test detecting netrin‐1 in solid tumors and allowing the selection of therapy‐eligible patients, we used the clinical‐grade NP137 agent and developed an indium‐111‐NODAGA‐NP137 single photon emission computed tomography (SPECT) contrast agent. NP137‐111In provided specific detection of netrin‐1‐positive tumors with an excellent signal‐to‐noise ratio using SPECT/CT imaging in different mouse models. The high specificity and strong affinity of NP137 paved the way for the generation of lutetium‐177‐DOTA‐NP137, a novel vectorized radiotherapy, which specifically accumulated in netrin‐1‐positive tumors. We demonstrate here, using tumor cell‐engrafted mouse models and a genetically engineered mouse model, that a single systemic injection of NP137‐177Lu provides important antitumor effects and prolonged mouse survival. Together, these data support the view that NP137‐111In and NP137‐177Lu may represent original and unexplored imaging and therapeutic tools against advanced solid cancers.
La voix de l’Autre. Singularités et altérités vocales dans les contacts entre Byzantins et leurs voisins occidentaux (IXe-XIIe s.)
Authors: Drocourt Nicolas 
Published: March 2023

AbstractEven though our sources globally make it difficult to hear the voices of individuals during the mid-Byzantine period, some of them give us a few insights, notably when Byzantine authorities are confronted with Western neighbours. Indeed, Byzantine singing and liturgic practices are frequently mentioned in Latin sources. They are often associated with other aspects of what one may call a “sound landscape”, and they are presented in a positive manner. But laughter and pronunciation are vocal variations that are usually more criticized in the perception ‘Latins’ and Byzantines have of each other. Furthermore, when political and military tensions arise, variations in the tone of voice of the Other can be severely judged and condemned. Finally, very often, voices heard within the context of encounters between ‘Latins’ and ‘Greeks’ may be associated with questions of order and disorder according to Byzantine authors.
Determinant Inequalities for Positive Definite Matrices via Cartwright–Field’s Result for Arithmetic and Geometric Weighted Means
Authors: Dragomir Silvestru Sever 
Published: March 2023

Assume that Aj, j ∈ {1, … , m} are positive definite matrices of order n. In this paper we prove among others that, if 0 < l In ≤ Aj, j ∈ {1, … , m} in the operator order, for some positive constant l, and In is the unity matrix of order n, thenwhere Pk ≥ 0 for k ϵ {1, …, m} and .
Optimizing chemistry for designing oxidation resistant FeCrAl alloys
Authors: Roy Indranil , Abouelella Hamdy , Umretiya Rajnikant V. , Roychowdhury Subhrajit , Feng Bojun , Ravi Sandipp Krishnan , Ghosh Sayan , Rebak Raul B. , Ruscitto Daniel M. , Gupta Vipul , Hoffman Andrew 
Published: March 2023

AbstractTraditionally, FeCrAl alloys played an important role in high-temperature applications due to their ability to form a passive Al oxide film at temperatures above ~ 800 °C. Recently, FeCrAl alloys became of interest for the application of accident tolerant nuclear fuel cladding. This study covers work done at GE Research for better understanding the role of Al, Cr, and Mo in oxidation kinetics and thermodynamics. Several models and commercial prototype alloys have been tested in hydrothermal corrosion autoclave loops, at low temperature steam exposure (~ 400 °C), high temperature steam exposure (~ 1000 °C or higher), and high temperature air exposures. The results provide insights on how chromium and aluminum play a significant role in both high temperature and low temperature oxidation of FeCrAl. Additionally, machine learning tools are used to gain further insights on both predicting future optimized chemistries for balancing the properties of hydrothermal corrosion, low and high temperature steam oxidation, and thermal aging (which is exacerbated due to radiation in a nuclear reactor environment). GE plans to use this framework to further optimize the FeCrAl alloy system for use in nuclear reactor environments.
Graphical abstract
Long noncoding RNA HOXA-AS2 ameliorates chronic intermittent hypoxia-induced lung inflammation by regulating miR-17-5p/tipe2 axis
Authors: Gao Kun , Lv Aiai , Zhang Qiang , Li Yanzhong , Yue Zhiyong , Xu Shuai 
Published: March 2023

Purpose: The purpose is to confirm whether long noncoding RNA HOXA-AS2 relieves chronic intermittent hypoxia (CIH)-induced lung inflammation.
Methods: Male Sprague Dawley rats were used to establisha CIH rat model. Hematoxylin and Eosin staining was used on the lung tissue injury to determine the successful construction of CIH animal model. Arterial partial pressure of oxygen (PaO2) and carbon dioxide (PaCO2) were measured. HOXA-AS2 was overexpressed to evaluate its role in the progression and development of CIH. T cell differentiation and cytokine production were determined using flow cytometry. Cell apoptosis was determined using terminal deoxynucleotidyl transferase dUTP nick end labelling assay kit. The target of HOXA-AS2 and miR-17-5p was predicted by the Encyclopedia of RNA Interactomes (ENCORI) and confirmed using luciferase assay.
Results: HOXA-AS2 was downregulated in CIH rat models. Lung tissue injury was observed in CIH rats, and the injury was attenuated by the overexpression of HOXA-AS2. PaO2 was reduced and PaCO2 was induced in CIH rats, which was reversed by the overexpression of HOXA-AS2. The overexpression of HOXA-AS2 inhibited CIH-induced cell apoptosis. It also reversed alterations in the levels of interferon gamma (IFNγ), interleukin (IL)-2, IL-6, IL-1β, tumor necrosis factor alpha (TNF-α), and transforming growth factor beta1 (TGF-β1) in rats caused by CIH. The overexpression of HOXA-AS2 prevented the induction in CD4+ IFN-γ+ T cells and reduction in CD4+TGF-β1+ T cells. The overexpression of HOXA-AS2 upregulated tumor necrosis factor-alpha-induced protein 8-like 2 (tipe2) key regulator through directly targeting miR-17-5p. Further experiments proved that tipe2 was the direct target of miR-17-5p.
Conclusion: This study manifested that HOXA-AS2 acted as an anti-inflammatory regulator and protected lung tissue injury from CIH in the rat model; this was mediated by upregulation of tipe2 through directly targeting miR-17-5p. HOXA-AS2 upregulated the expression of tipe2, providing new understanding and therapeutic target for CIH.
LINC00632 relates to milder Th1/Th2 imbalance, attenuated nasal symptoms, and better response to therapy in allergic rhinitis patients
Authors: Shi Yanan , Zhang Guimin , Ji Ran , Zhang Shengchi , Shen Shaobo 
Published: March 2023

Objective: Long intergenic noncoding RNA 00632 (LINC00632) regulates nasal inflammation and CD4+ T cell differentiation into T helper (Th) 2 cells in allergic rhinitis (AR). This study aimed to explore the relationship between LINC00632 and Th1/Th2 balance, and the clinical value of LINC00632 in AR patients.
Methods: In total, 120 AR patients, 20 non-atopic obstructive snoring patients as disease controls (DCs), and 20 healthy controls (HCs) were recruited. Their LINC00632 expressions in peripheral blood mononuclear cells were detected by RT-qPCR.
Results: LINC00632 expression was declined in AR patients compared with DCs and HCs (both P ˂ 0.001). Moreover, LINC00632 could distinguish AR patients from DCs with an area under curve (AUC) of 0.795 (95% confidence interval [CI]: 0.701–0.889), and from HCs with an AUC of 0.895 (95%CI: 0.831–0.960). LINC00632 was positively related to Th1 cells (P = 0.037) and Th1/Th2 axis (P ˂ 0.001) in AR patients. In addition, LINC00632 was inversely associated with Th2 cells (P ˂ 0.001) and interleukin (IL)-4 (P = 0.010) in AR patients. Besides, LINC00632 was negatively related to rhinorrhea score (P = 0.019), itching score (P = 0.008), sneezing score (P = 0.004), and total nasal symptom score (TNSS) (P ˂ 0.001), but no correlation between LINC00632 and congestion score was observed (P = 0.093). During treatment, LINC00632 was elevated, while TNSS score was reduced (both P ˂ 0.001). Furthermore, LINC00632 increment was associated with the reduction of TNSS score during the therapy (P = 0.005).
Conclusion: LINC00632 relates to milder Th1/Th2 imbalance, attenuated nasal symptoms, and better response during 4-week therapy in AR patients.
MOVIMENTO DAS REPRESENTAÇÕES SOCIAIS DOS PROFESSORES SOBRE CAMPO NO PERU E NO BRASIL
Authors: Freitas Erica Fernanda Justino de , Rocha Maria Isabel Antunes 
Published: March 2023

Este texto descreve parte dos processos de uma pesquisa de doutorado em Educação desenvolvida na Universidade Federal de Minas Gerais. Considerando a Pedagogia da Alternância um instrumento histórico nas lutas das populações camponesas no Peru e no Brasil pelo direito à educação, torna-se relevante discutir as relações que se estabelecem em um contexto educacional contra hegemônico que se compromete com as questões do universo camponês e pressiona os professores a se posicionarem. Dessa forma, os referenciais teóricos foram estudados à luz das Representações Sociais em Movimento que colocam em diálogo realidades educacionais camponesas distintas, mas semelhantes em termos sócio/históricos. O texto apresenta reflexões sobre o processo de movimentação das representações sociais sobre campo de professores que atuam em contextos geradores de mudança,
apontando movimentos representacionais de reelaboração, de manutenção e de recusa. Este texto contribui teoricamente com a compreensão da perspectiva do movimento em estudos sobre a Teoria das Representações Sociais, a partir da análise de experiências sobre objetos comuns em diferentes contextos educativos.
Sharia Card: An Alternative For Islamic Payment
Authors: Yusuf Mahmud 
Published: March 2023

The formulation of the problem in this study is to narrate the sharia card as a solution for using credit cards in the community. The research method used is the library research method with content analysis as an analytical knife so that the right solution is found in drawing conclusions. To ensure the validity of the data, the researcher will use the triangulation technique of sources derived from various literatures that are relevant to the research theme. The results showed that credit cards in traditional banks, this is a method of payment for the purchase and sale of goods and services, and it is possible to pay at once or in installments up to a certain minimum amount (ba’i bit-taqsith), which is haram. To avoid it, sharia cards use Islamic principle., which is not used for transactions that are not in accordance with sharia, and does not encourage excessive consumption. The main card holder must have the financial ability to pay off on time and must not provide services that are contrary to sharia. Tujuan penelitian ini adalah untuk menganalisa eksistensi kartu syariah sebagai solusi penggunaan kartu kredit di masyarakat. Metode penelitian yang digunakan adalah metode penelitian kepustakaan dengan pendekatan content analisis untuk menemukan solusi yang tepat dalam penarikan kesimpulan. Penulis menggunakan teknik triangulasi sumber dari berbagai literatur yang relevan dengan tema penelitian untuk menjamin keabsahan data. Hasil penelitian menunjukkan bahwa kartu kredit di bank konvensional yang merupakan metode pembayaran untuk pembelian dan penjualan barang serta jasa, di mana pembayarannya dapat dilakukan sekaligus atau dicicil hingga jumlah minimum tertentu termasuk dalam kategori riba yang haram. Maka untuk menghindarinya, kartu syariah menggunakan prinsip Islam, yaitu yang tidak menyebabkan sifat konsumtif dan tidak digunakan untuk transaksi yang tidak sesuai syariah. Pemegang kartu utama harus memiliki kemampuan finansial untuk melunasi tepat waktu dan tidak boleh memberikan pelayanan yang bertentangan dengan syariah.
Análisis del Ciclo de Madurez Tecnológica de Superficies Antibacterianas y Autolimpiantes a base de TiO2/ZnO
Authors: Sinisterra Santiago , Camargo-Amado Rubén , Triviño Diego , Machuca Martínez Fiderman 
Published: March 2023

El desarrollo de nanomateriales cerámicos con propiedades autolimpiantes es un campo de investigación importante ya que pueden ser usados en diferentes sectores como la industria textil, aeroespacial, automotriz y en elementos de protección biomédica. En este contexto, el objetivo del trabajo es analizar e identificar las tendencias mundiales en investigación, nivel de innovación, así como las tecnologías emergentes en el desarrollo de nanopartículas de TiO2/ZnO con propiedades antibacteriales y autolimpiantes; a partir del seguimiento tecnológico de patentes y Trabajos académicos mediante el uso de métodos bibliométricos usando el software de análisis bibliométrico Lens.
Se estimaron las etapas de desarrollo tecnológico a través del modelo logístico usando el software Loglet Lab 4 y se calcularon los parámetros de Yoon, tasa de madurez tecnológica (TMR), patentes potenciales por aparecer (EPP), tiempo de vida remanente (ERL), con 4 indicadores definidos: Patentes otorgadas (i1), aplicaciones de patentes (i2), trabajos académicos (i3) y capital humano (i4).
La tendencia tecnológica de las patentes para el primer periodo (período I) se enfocaron en el desarrollo de procesos de catálisis, mientras que en el período II en tecnología de fabricación de cosméticos y desinfectantes. En el período III aparece la nanotecnología aplicada en cosméticos y procesos de desinfección, finalmente, en el período IV se observó una tendencia hacia los procesos de desinfección y recubrimientos, así como también la cantidad de aplicaciones de patentes para este período. Japón es el país líder en esta tecnología actualmente y la compañía Gearbox LLC encabeza la lista de mayor cantidad de patentes otorgadas.
Esta tecnología de superficies autolimpiantes registró en promedio una tasa de madurez del 51.48%, con lo cual se ubica en una etapa de madurez, siendo una tecnología catalogada en el inicio de su fase como “tecnología líder” con posibilidad de inversión en el desarrollo de nuevos productos y procesos.