bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dayside Vertical Wind Reversal at Transition Altitude From E to F Regions Observed by the ICON Satellite
Authors: Huang Yuyang , Xiong Chao , Wu Jiawei , Stolle Claudia , Wang Fengjue , Zheng Yuhao , Xu Chunyu , Hu Yang , Wang Simin 
Published: May 2023

AbstractThe Michelson Interferometer for Global High‐Resolution Thermospheric Imaging (MIGHTI) onboard the Ionospheric Connection Explorer (ICON) mission measures the neutral winds from about 88 to 310 km altitudes, which provides a good opportunity to investigate the vertical distribution of the neutral winds. In this study we used the green line of MIGHTI to focus on the wind reversal due to large vertical shears at the transition altitude from E to F regions (∼120–220 km). For the limitations of green line filter during night‐time, we therefore present only the results on the dayside from 0600 to 1800 local time (LT). Based on more than 2 years data, there were 206 and 96 orbits identified with clear wind reversal in the meridional and zonal components, respectively. These events almost covered the whole altitude of ∼120–220 km. Interestingly, such wind reversal occurs mostly (about 75%) during magnetic quiet periods with Kp less than 2. Their dependences on LT, geographic latitude (Glat) and longitude (Glon) have been further analyzed. Two different trends for the wind reversals on LT dependence have been found, for example, the mean altitude of meridional (zonal) wind reversal is higher at dawn, and then slowly decreases toward dusk; or the mean altitude of wind reversal is higher at dusk and slowly decreases toward dawn. Such two kinds of altitude trends of wind reversal are also found for the dependence on Glat, but not on Glon. In addition, we find that there are about 90% orbits with wind reversal simultaneously observed at the low E and F regions, but the altitude variations of wind reversal can be the same or opposite in the two regions, even for the same orbit. This result suggests that the wind reversals at the low E and low F regions should be different. The climatology of the wind reversals at low F region observed by ICON provides helpful constrain for the neutral wind simulation based on physical models.
The Upper‐Mantle Structure Beneath Alaska Imaged by Teleseismic S‐Wave Reverberations
Authors: Hao Shangqin , Shearer Peter , Liu Tianze 
Published: May 2023

AbstractAlaska is a tectonically active region with a long history of subduction and terrane accretion, but knowledge of its deep seismic structure is limited by a relatively sparse station distribution. By combining data from the EarthScope Transportable Array and other regional seismic networks, we obtain a high‐resolution state‐wide map of the Moho and upper‐mantle discontinuities beneath Alaska using teleseismic SH‐wave reverberations. Crustal thickness is generally correlated with elevation and the deepest Moho is in the region with basal accretion of the subducted Yakutat plate, consistent with its higher density due to a more mafic composition. The crustal thickness in the Brooks Range agrees with the prediction based on Airy isostasy and the weak free‐air gravity anomaly, suggesting that this region probably does not have significant density anomalies. We also resolve the 410, 520, and 660 discontinuities in most regions, with a thickened mantle transition zone (MTZ) and a normal depth difference between the 520 and 660 discontinuities (d660‐d520) under central Alaska, indicating the presence of the subducted Pacific slab in the upper MTZ. A near‐normal MTZ and a significantly smaller d660‐d520 are resolved under southeastern Alaska, suggesting potential mantle upwelling in the lower MTZ. Beneath the Alaska Peninsula, the thinned MTZ implies that the Pacific slab may not have reached the MTZ in this region, which is also consistent with recent tomography models. Overall, the results demonstrate a bent or segmented Pacific slab with varying depths under central Alaska and the Alaska Peninsula.
Inside-out assembly of viral antigens for the enhanced vaccination
Authors: Cao Fengqiang , Peng Sha , An Yaling , Xu Kun , Zheng Tianyi , Dai Lianpan , Ogino Kenji , Ngai To , Xia Yufei , Ma Guanghui 
Published: May 2023

AbstractCurrent attempts in vaccine delivery systems concentrate on replicating the natural dissemination of live pathogens, but neglect that pathogens evolve to evade the immune system rather than to provoke it. In the case of enveloped RNA viruses, it is the natural dissemination of nucleocapsid protein (NP, core antigen) and surface antigen that delays NP exposure to immune surveillance. Here, we report a multi-layered aluminum hydroxide-stabilized emulsion (MASE) to dictate the delivery sequence of the antigens. In this manner, the receptor-binding domain (RBD, surface antigen) of the spike protein was trapped inside the nanocavity, while NP was absorbed on the outside of the droplets, enabling the burst release of NP before RBD. Compared with the natural packaging strategy, the inside-out strategy induced potent type I interferon-mediated innate immune responses and triggered an immune-potentiated environment in advance, which subsequently boosted CD40+ DC activations and the engagement of the lymph nodes. In both H1N1 influenza and SARS-CoV-2 vaccines, rMASE significantly increased antigen-specific antibody secretion, memory T cell engagement, and Th1-biased immune response, which diminished viral loads after lethal challenge. By simply reversing the delivery sequence of the surface antigen and core antigen, the inside-out strategy may offer major implications for enhanced vaccinations against the enveloped RNA virus.
Long-term exposure to air pollution and severe COVID-19 in Catalonia: a population-based cohort study
Authors: Ranzani Otavio , Alari Anna , Olmos Sergio , Milà Carles , Rico Alex , Ballester Joan , Basagaña Xavier , Chaccour Carlos , Dadvand Payam , Duarte-Salles Talita , Foraster Maria , Nieuwenhuijsen Mark , Sunyer Jordi , Valentín Antònia , Kogevinas Manolis , Lazcano Uxue , Avellaneda-Gómez Carla , Vivanco Rosa , Tonne Cathryn 
Published: May 2023

AbstractThe association between long-term exposure to ambient air pollutants and severe COVID-19 is uncertain. We followed 4,660,502 adults from the general population in 2020 in Catalonia, Spain. Cox proportional models were fit to evaluate the association between annual averages of PM2.5, NO2, BC, and O3 at each participant’s residential address and severe COVID-19. Higher exposure to PM2.5, NO2, and BC was associated with an increased risk of COVID-19 hospitalization, ICU admission, death, and hospital length of stay. An increase of 3.2 µg/m3 of PM2.5 was associated with a 19% (95% CI, 16–21) increase in hospitalizations. An increase of 16.1 µg/m3 of NO2 was associated with a 42% (95% CI, 30–55) increase in ICU admissions. An increase of 0.7 µg/m3 of BC was associated with a 6% (95% CI, 0–13) increase in deaths. O3 was positively associated with severe outcomes when adjusted by NO2. Our study contributes robust evidence that long-term exposure to air pollutants is associated with severe COVID-19.
Oxidative cleavage and ammoxidation of organosulfur compounds via synergistic Co-Nx sites and Co nanoparticles catalysis
Authors: Luo Huihui , Tian Shuainan , Liang Hongliang , Wang He , Gao Shuang , Dai Wen 
Published: May 2023

AbstractThe cleavage and functionalization of C–S bonds have become a rapidly growing field for the design or discovery of new transformations. However, it is usually difficult to achieve in a direct and selective fashion due to the intrinsic inertness and catalyst-poisonous character. Herein, for the first time, we report a novel and efficient protocol that enables direct oxidative cleavage and cyanation of organosulfur compounds by heterogeneous nonprecious-metal Co-N-C catalyst comprising graphene encapsulated Co nanoparticles and Co-Nx sites using oxygen as environmentally benign oxidant and ammonia as nitrogen source. A wide variety of thiols, sulfides, sulfoxides, sulfones, sulfonamides, and sulfonyl chlorides are viable in this reaction, enabling access to diverse nitriles under cyanide-free conditions. Moreover, modifying the reaction conditions also allows for the cleavage and amidation of organosulfur compounds to deliver amides. This protocol features excellent functional group tolerance, facile scalability, cost-effective and recyclable catalyst, and broad substrate scope. Characterization and mechanistic studies reveal that the remarkable effectiveness of the synergistic catalysis of Co nanoparticles and Co-Nx sites is crucial for achieving outstanding catalytic performance.
Hyperphosphorylated PTEN exerts oncogenic properties
Authors: van Ree Janine H. , Jeganathan Karthik B. , Fierro Velasco Raul O. , Zhang Cheng , Can Ismail , Hamada Masakazu , Li Hu , Baker Darren J. , van Deursen Jan M. 
Published: May 2023

AbstractPTEN is a multifaceted tumor suppressor that is highly sensitive to alterations in expression or function. The PTEN C-tail domain, which is rich in phosphorylation sites, has been implicated in PTEN stability, localization, catalytic activity, and protein interactions, but its role in tumorigenesis remains unclear. To address this, we utilized several mouse strains with nonlethal C-tail mutations. Mice homozygous for a deletion that includes S370, S380, T382 and T383 contain low PTEN levels and hyperactive AKT but are not tumor prone. Analysis of mice containing nonphosphorylatable or phosphomimetic versions of S380, a residue hyperphosphorylated in human gastric cancers, reveal that PTEN stability and ability to inhibit PI3K-AKT depends on dynamic phosphorylation-dephosphorylation of this residue. While phosphomimetic S380 drives neoplastic growth in prostate by promoting nuclear accumulation of β-catenin, nonphosphorylatable S380 is not tumorigenic. These data suggest that C-tail hyperphosphorylation creates oncogenic PTEN and is a potential target for anti-cancer therapy.
Ab initio quantum simulation of strongly correlated materials with quantum embedding
Authors: Cao Changsu , Sun Jinzhao , Yuan Xiao , Hu Han-Shi , Pham Hung Q. , Lv Dingshun 
Published: May 2023

AbstractQuantum computing has shown great potential in various quantum chemical applications such as drug discovery, material design, and catalyst optimization. Although significant progress has been made in the quantum simulation of simple molecules, ab initio simulation of solid-state materials on quantum computers is still in its early stage, mostly owing to the fact that the system size quickly becomes prohibitively large when approaching the thermodynamic limit. In this work, we introduce an orbital-based multifragment approach on top of the periodic density matrix embedding theory, resulting in a significantly smaller problem size for the current near-term quantum computer. We demonstrate the accuracy and efficiency of our method compared with the conventional methodologies and experiments on solid-state systems with complex electronic structures. These include spin-polarized states of a hydrogen chain (1D-H), the equation of state of a boron nitride layer (h-BN) as well as the magnetic ordering in nickel oxide (NiO), a prototypical strongly correlated solid. Our results suggest that quantum embedding combined with a chemically intuitive fragmentation can greatly advance quantum simulation of realistic materials, thereby paving the way for solving important yet classically hard industrial problems on near-term quantum devices.
Developmental and reproductive toxicity of a recombinant protein subunit COVID-19 vaccine (ZF2001) in rats
Authors: Song Yisheng , Shao Jinjin , She Guangbiao , Lv Wanqiang , Chen Guoyu , Liu Jing , Zhang Lili , Zhang Chengda , Wang Jiahong , Tian Ruiyu , Dai Lianpan , Gao George F. , Huang Enqi , Zhang Lijiang 
Published: May 2023

AbstractZF2001, a protein subunit vaccine against coronavirus disease 2019 (COVID-19), contains recombinant tandem repeat of dimeric receptor-binding domain (RBD) protein of the SARS-CoV-2 spike protein with an aluminium-based adjuvant. During the development of this vaccine, two nonclinical studies were conducted to evaluate female fertility, embryo-fetal development, and postnatal developmental toxicity in Sprague‒Dawley rats according to the ICH S5 (R3) guideline. In Study 1 (embryo-fetal developmental toxicity, EFD), 144 virgin female rats were randomly assigned into four groups and received three doses of vaccine (25 μg or 50 μg RBD protein/dose, containing the aluminium-based adjuvant), the aluminium-based adjuvant or a sodium chloride injection administered intramuscularly on days 21 and 7 prior to mating and on gestation day (GD) 6. In Study 2 (pre- and postnatal developmental toxicity, PPND), ZF2001 at a dose of 25 μg RBD protein/dose or sodium chloride injection was administered intramuscularly to female rats (n = 28 per group) 7 days prior to mating and on GD 6, GD 20 and postnatal day (PND) 10. There were no obvious adverse effects in dams, except for local injection site reactions related to the aluminium-based adjuvant (yellow nodular deposits in the interstitial muscle fibres). There were also no effects of ZF2001 on the mating performance, fertility or reproductive performance of parental females, embryo-fetal development, postnatal survival, growth, physical development, reflex ontogeny, behavioural and neurofunctional development, or reproductive performance of the offspring. The strong immune responses associated with binding and neutralising antibodies were both confirmed in dams and fetuses or offspring in these two studies. These results would support clinical trials or the use of ZF2001 in maternal immunisation campaigns, including those involving women with childbearing potential, regardless of pregnancy status.
Chloroplast genome characterization of Uncaria guianensis and Uncaria tomentosa and evolutive dynamics of the Cinchonoideae subfamily
Authors: Castro Andrezza Arantes , Nunes Rhewter , Carvalho Larissa Resende , Targueta Cíntia Pelegrineti , dos Santos Braga-Ferreira Ramilla , de Melo-Ximenes Amanda Alves , Corvalán Leonardo Carlos Jeronimo , Bertoni Bianca Waleria , Pereira Ana Maria Soares , de Campos Telles Mariana Pires 
Published: May 2023

AbstractUncariaspecies are used in traditional medicine and are considered of high therapeutic value and economic importance. This work describes the assembly and annotation of the chloroplast genomes ofU. guianensisandU. tomentosa, as well as a comparative analysis. The genomes were sequenced on MiSeq Illumina, assembled with NovoPlasty, and annotated using CHLOROBOX GeSeq. Addictionaly, comparative analysis were performed with six species from NCBI databases and primers were designed in Primer3 for hypervariable regions based on the consensus sequence of 16 species of the Rubiaceae family and validated on an in-silico PCR in OpenPrimeR. The genome size ofU. guianensis and U. tomentosawas 155,505 bp and 156,390 bp, respectively. Both Species have 131 genes and GC content of 37.50%. The regionsrpl32-ccsA, ycf1,andndhF-ccsAshowed the three highest values of nucleotide diversity within the species of the Rubiaceae family and within theUncaria genus, these regions weretrnH-psbA,psbM-trnY,andrps16-psbK.Our results indicates that the primer of the regionndhAhad an amplification success for all species tested and can be promising for usage in the Rubiaceae family. The phylogenetic analysis recovered a congruent topology to APG IV. The gene content and the chloroplast genome structure of the analyzed species are conserved and most of the genes are under negative selection. We provide the cpDNA of NeotropicalUncariaspecies, an important genomic resource for evolutionary studies of the group.
Unraveling attributes of COVID-19 vaccine acceptance and uptake in the U.S.: a large nationwide study
Authors: McCabe Sean D. , Hammershaimb E. Adrianne , Cheng David , Shi Andy , Shyr Derek , Shen Shuting , Cole Lyndsey D. , Cataldi Jessica R. , Allen William , Probasco Ryan , Silbermann Ben , Zhang Feng , Marsh Regan , Travassos Mark A. , Lin Xihong 
Published: May 2023

AbstractSARS-CoV-2 vaccines are useful tools to combat the Coronavirus Disease 2019 (COVID-19) pandemic, but vaccine reluctance threatens these vaccines’ effectiveness. To address COVID-19 vaccine reluctance and ensure equitable distribution, understanding the extent of and factors associated with vaccine acceptance and uptake is critical. We report the results of a large nationwide study in the US conducted December 2020-May 2021 of 36,711 users from COVID-19-focused smartphone-based app How We Feel on their willingness to receive a COVID-19 vaccine. We identified sociodemographic and behavioral factors that were associated with COVID-19 vaccine acceptance and uptake, and we found several vulnerable groups at increased risk of COVID-19 burden, morbidity, and mortality were more likely to be reluctant to accept a vaccine and had lower rates of vaccination. Our findings highlight specific populations in which targeted efforts to develop education and outreach programs are needed to overcome poor vaccine acceptance and improve equitable access, diversity, and inclusion in the national response to COVID-19.
A randomized controlled trial of effects of open-label placebo compared to double-blind placebo and treatment-as-usual on symptoms of allergic rhinitis
Authors: Schaefer Michael , Zimmermann Kurt , Enck Paul 
Published: May 2023

AbstractPlacebo effects are known for numerous clinical symptoms. Until recently, deception of placebos was thought to be essential for placebo effects, but intriguing new studies suggest that even placebos without concealment (open-label placebos) may help patients with various clinical disorders. Most of those studies compared open-label placebo treatments with no treatment conditions (or treatment “as usual”). Given that open-label placebo studies obviously cannot be blinded, additional control studies are important to assess the efficacy of open-label placebos. The current study aimed to fil this gap by comparing open-label with conventional double-blind placebos and treatment as usual. Patients with seasonal allergic rhinitis were randomly divided in different groups. The first group received open-label placebos, the second double-blind placebos, and the third was treated as usual. After 4 weeks, results demonstrated that open-label placebos improved allergic symptoms more than treatment-as-usual and even more as double-blind placebos. In addition, we observed that allergic symptoms in general (and also the open-label placebo effects) were reduced by the Covid-19 pandemic. The results suggest that seasonal allergic symptoms may be relieved by open-label placebos. We discuss these results by addressing possible different mechanisms of open-label and conventionally concealed placebo treatments.
Modified stepping behaviour during outdoor winter walking increases resistance to forward losses of stability
Authors: Best Aaron N. , Wu Amy R. 
Published: May 2023

AbstractHealthy humans are proficient at maintaining stability when faced with diverse walking conditions, however, the control strategies that lead to this proficiency are unclear. Previous laboratory-based research has predominantly concluded that corrective stepping is the main strategy, but whether this finding holds when facing everyday obstacles outside of the laboratory is uncertain. We investigated changes in gait stability behaviour when walking outdoors in the summer and winter, hypothesizing that as ground conditions worsened in the winter, the stepping strategy would be hindered. Stability would then be maintained through compensatory strategies such as with ankle torques and trunk rotation. Data was collected in the summer and winter using inertial measurement units to collect kinematics and instrumented insoles to collect vertical ground reaction forces. Using the goodness of fit for a multivariate regression between the centre of mass state and foot placement we found that, counter to our hypothesis, stepping was not hindered by winter conditions. Instead, the stepping strategy was modified to increase the anterior-posterior margin of stability, increasing the resistance to a forward loss of stability. With stepping being unhindered, we did not observe any additional compensation from the ankle or trunk strategies.
A reconfigurable graphene patch antenna inverse design at terahertz frequencies
Authors: Mashayekhi Mohammad , Kabiri Pooria , Nooramin Amir Saman , Soleimani Mohammad 
Published: May 2023

AbstractThis article investigates the inverse design of a reconfigurable multi-band patch antenna based on graphene for terahertz applications to operate frequency range (2–5THz). In the first step, this article evaluates the dependence of the antenna radiation characteristics on its geometric parameters and the graphene properties. The simulation results show that it is possible to achieve up to 8.8 dB gain, 13 frequency bands, and 360$$^\circ$$

∘

beam steering. Then and due to the complexity of the design of graphene antenna, a deep neural network (DNN) is used to predict the antenna parameters by given inputs like desired realized gain, main lobe direction, half power beam width, and return loss in each resonance frequency. The trained DNN model predicts almost with 93% accuracy and 3% mean square error in the shortest time. Then, this network was used to design five-band and three-band antennas, and it has been shown that the desired antenna parameters are achieved with negligible errors. Therefore, the proposed antenna finds many potential applications in the THz frequency band.
Enhancing the upconversion efficiency of NaYF4:Yb,Er microparticles for infrared vision applications
Authors: Khosh Abady Keyvan , Dankhar Dinesh , Krishnamoorthi Arjun , Rentzepis Peter M. 
Published: May 2023

AbstractIn this study, (NaYF4:Yb,Er) microparticles dispersed in water and ethanol, were used to generate 540 nm visible light from 980 nm infrared light by means of a nonlinear stepwise two-photon process. IR-reflecting mirrors placed on four sides of the cuvette that contained the microparticles increased the intensity of the upconverted 540 nm light by a factor of three. We also designed and constructed microparticle-coated lenses that can be used as eyeglasses, making it possible to see rather intense infrared light images that are converted to visible.