bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arrhythmias in Pregnancy. Experience of the Multidisciplinary Team
Authors: Siromakha Sergii O. , Davydova Iuliia V. , Kravchuk Borys B. , Zalevskiy Valerii P. , Nakonechna Nataliia B. , Lazoryshynets Vasyl V. 
Published: December 2022

Arrhythmia is the main cause of pregnancy-related hospitalizations. Potential risk of arrhythmias during pregnancy is associated with hypercoagulation and increased risk of thromboembolism.
The aim. To increase patients’ safety and to improve maternal and perinatal outcomes by choosing the optimal medical strategy.
Methods. We present the experience of multidisciplinary care for 54 pregnant and parturient women (32 with tachy-, 20 with bradyarrhythmia and 2 with ventricular asynchrony) who were admitted to the cardiac surgery facility from December 2013 to February 2022. Pacemakers were implanted in 15 cases of complete atrioventricular block radiofrequency ablation was performed in 12 cases.
Results. There were no near misses and maternal losses in our group of patients. Two programmed perinatal losses were provided in patients with rhythm disorders and complex congenital heart defects. Type and place of delivery were chosen by the multidisciplinary team. There were nine childbirths at a specialized cardiac surgery clinic. There were no perinatal losses among patients who underwent rhythm interventions. In our group of patients, electrical cardioversion was performed in three cases, the pregnancies ended successfully with the birth of healthy newborns.
Conclusions. Arrhythmias in all trimesters of pregnancy and the postpartum period are a common reason for seeking medical attention and hospitalization during pregnancy.Most of the arrhythmias are hemodynamically insignificant and don’t require hospitalization. Maternal risk stratification of major cardiac events during pregnancy, childbirth and the postpartum period is the cornerstone for choosing a strategy of medical care for pregnant women with arrhythmias. Patients with hemodynamic manifestations of tachy- and bradyarrhythmias, as well as patients with life-threatening types of rhythm disturbances are in the focus of attention of pregnancy heart team. Preconceptional management of patients with life threating arrhythmias is the best type of care in these patients. Pregnancy and delivery in high-risk class patients should be managed in an experienced center with on-site interventional electrophysiology techniques. Rhythm interventions have extremely limited indications and can be conducted when less invasive treatment strategy is unsuccessful.
On the way to maturity...
Authors: De Souza Nery Caio Augusto , Godoy-Santos Alexandre Leme 
Published: December 2022

As we close another year of existence with the publication of this third issue of volume 16, we take the opportunity to share with everyone the joy of having complied with the requirements of the indexing platforms, reaching the milestones outlined for the first three years of the JFA.

Thanks to the joint effort of authors, reviewers, editors, and management team, who prepare, organize, and produce the journal, we achieved the appropriate temporal, quantitative, and qualitative flows whose results are expressed by the publication of 180 articles in three years.

We must celebrate the participation of countries worldwide, which surprised us with their interest in our vehicle of scientific dissemination. The chart and table below demonstrate that important countries such as the USA, Spain, Portugal, South Africa, and Australia have already become familiar with our system and honored us with their submissions.
But we still have a lot to do!!!

In addition to encouraging Latin American countries to collaborate more effectively by sending their studies, we would like to have young professionals on our side. It would be extremely useful for everyone if the training services for Foot and Ankle specialists throughout Latin America considered performing scientific studies and publishing them in the JFA as one of the technical training requirements. The research growth and published studies in our continent would soon be rewarded by the improvement in care and outcomes for our patients, the greatest objective of all.

The renewal and expansion of the Board of Reviewers started this year will continue, and soon, we hope to reduce even more the evaluation and decision time of each submission, in addition to improving, every day, the standard of revisions.

In this moment of reflection in which we see the end of another difficult year where we feel all the serious consequences of the pandemic that has hit humanity, we can celebrate a small victory achieved by every one of us who participated in constructing our journal to whom we are most grateful.

Happy Holidays to all!
The philosophy of the heart of Hryhoriy Skovoroda: a pedagogical view of the teachings of the outstanding Ukrainian thinker
Authors: Dovzhenko T. , Nebytova I. 
Published: December 2022

The article presents a pedagogical view of the philosophical teachings of the heart of Hryhoriy Skovoroda. The works of followers and biographers of are analyzed. H. Skovoroda, which outline the life of the philosopher. It is determined that the teachings of the heart are based on the idea of three worlds: the first – the macrocosm (Universe), the second – the microcosm (man), the third – the symbolic reality (Bible), which connects these two worlds and reflects them in itself. Quotes from the leading works of H. Skovoroda characterizing his philosophical doctrine of the heart. It is determined that the feelings and heart of H. Skovoroda became an instrument of knowledge, deepened the space of contemporary traditional science and brought his scientific thought to cosmic reality. Fragments of the biography of H. Skovoroda reflecting his philosophical views. It has been proved that in the history of Ukrainian culture the teachings of Hryhoriy Skovoroda became the starting point in the knowledge of the heart, combining religious and philosophical knowledge about it: the purified and enlightened human heart is the most important organ of metacognition (heart feeling).
LOS GRABADOS DE CUADRÚPEDOS EN EL ARTE RUPESTRE ATLÁNTICA. DISTRIBUCIÓN Y ANÁLISIS ESTILÍSTICA
Authors: Pereira-Martínez Xurxo , Méndez-Quintas Eduardo , Martínez Pilar Prieto Martínez Prieto 
Published: December 2022

Resumo:
El objetivo de este trabajo es mostrar el patrón de distribución de las figuras de zoomorfos en el noroeste ibérico, apartir de los datos recopilados por las diferentes administraciones de Galicia y Portugal, y de las prospeccionesrealizadas en el área del Miño litoral (Norte de Portugal y Suroeste gallego). Ofrecemos una síntesis actualizada sobreeste tipo de representaciones rupestres, con el estudio de 169 superficies con figuras de zoomorfos, analizando elemplazamiento de este tipo de motivos, siguiendo diferentes criterios como la especie de animal representado y/o lavariabilidad estilística. En base a los datos arqueológicos disponibles planteamos una atribución cronológica, para estetipo de representaciones de animales, dentro del último milenio B.C.
Palavras-chave: Arte Rupestre Atlántica, Zoomorfos, Cuadrúpedos, Noroeste Peninsular, Estilo.
Abstract:
The aim of this paper is to display the distribution pattern of zoomorphic figures in the northwest Iberian Peninsula,based on the data collected by the different administrative territories of Galicia and Northern Portugal and the surveyscarried out in the area of the coastal Minho (North of Portugal and Southwest Galicia). We provide an updatedsynthesis of this type of rock representations, with the study of 169 rock surfaces with zoomorphic figures, analysingthe location of this type of motifs, following different criteria such as the species of animal represented and/or stylisticvariability. Based on available archaeological data, we propose a chronological attribution for this type of animalrepresentations within the last millennium BC.
Keywords: Atlantic Rock Art, Zoomorphs, Quadrupeds, Northwest Iberia, Style.
Aspects and issues of marketing authorisation and use of medicinal products for COVID-19 prevention during the pandemic
Authors: Soldatov A. A. , Gorenkov D. V. , Merkulov V. A. , Bondarev V. P. 
Published: December 2022

At the end of 2019, an outbreak of a new coronavirus began in the city of Wuhan (Hubei Province) in the People's Republic of China. The outbreak turned into a pandemic. In the shortest possible time, national and international manufacturers developed preventive COVID-19 vaccines, and the population was vaccinated. During pandemics, accelerated approval of vaccines is an important factor that shortens the time to market with the aim of mass vaccination. The experience of rapidly developing and introducing vaccines into routine practice is not only important for managing the current pandemic, but also valuable in case of extremely likely future ones. The aim of this study was to analyse the main issues associated with assessing the safety and efficacy of vaccines for COVID-19 prevention during their registration and widespread use amid the pandemic and ongoing SARS-CoV-2 evolution. The vaccines for COVID-19 prevention were developed and introduced into healthcare practice very rapidly and under the circumstances of the pandemic, and the use of these vaccines has surfaced a number of concerns requiring further research. The most important issues identified in the performed analysis include, but are not limited to the need for accelerated assessment of the safety and immunogenicity of new vaccines; the lack of immune correlates of protection against SARS-CoV-2; the waning of antibody immunity over time, motivating the need to determine revaccination and post-recovery vaccination timelines; and the emergence of mutant SARS-CoV-2 variants. One of noteworthy aspects is the need to develop recommendations for updating the strain composition of registered COVID-19 vaccines. According to the conclusions, the level of herd immunity, including vaccine-induced protection, plays a certain role in virus evolution during the pandemic. If COVID-19 becomes seasonal, which is a probable scenario, regular revaccination can be essential.
Selection of a SARS-CoV-2 antibody quantification method and development of an antibody reference standard for ELISA to test immunoglobulin preparations
Authors: Smolyanova T. I. , Nikolaeva A. M. , Vyaznikova T. V. , Ivanov A. V. , Belyakova O. V. , Sakanyan E. I. 
Published: December 2022

The development of COVID-globulin, a COVID-19-specific human immunoglobulin preparation, involved choosing a method to quantify antibodies to SARS-CoV-2. Antibody titre determination by virus neutralisation (VN) is labour-intensive and unsuitable for large-scale application. To enable routine testing, it was necessary to develop a less demanding method; the enzyme-linked immunosorbent assay (ELISA) was the most appropriate of solutions. The lack of international and industry reference standards (RS) prompted the preparation and certification of an RS for COVID-globulin potency control.The aim of the study was to examine the possibility of substituting ELISA for VN and to develop an RS for SARS-CoV-2 antibody quantification in immunoglobulin preparations.Materials and methods: the authors used commercial ELISA kits by several manufacturers, COVID-globulin by Microgen (48 batches), and human plasma samples from multiple sources (1499 samples). The tests were performed by VN, ELISA, and chemiluminescent microparticle immunoassay.Results: the authors validated an ELISA method for SARS-CoV-2 antibody quantification with the selected reagent kits by the National Medical Research Center for Hematology (NMRC for Hematology) and Euroimmun AG. The authors demonstrated the possibility of using ELISA instead of VN (with a correlation coefficient of more than 0.9). They developed and characterised an in-house RS for SARS-CoV-2 antibody content in human immunoglobulin preparations. The RS was certified in newly introduced anti-COVID units (ACU) and in international binding antibody units (BAU) using the World Health Organisation (WHO) international reference panel (NIBSC code: 20/268). The RS's potency was measured in terms of its neutralising activity in ACU (320 ACU/mL) and BAU (2234.8 BAU/mL). The authors established the relationship between ACU and BAU units. For the selected ELISA reagent kits, the conversion factors were 6.4 (NMRC for Hematology) and 7.0 (Euroimmun AG).Conclusions: the ELISA method for SARS-CoV-2 antibody quantification and the RS for SARS-CoV-2 antibody content can be applied to determine the potency of human anti-COVID-19 immunoglobulins.
The use of quantitative enzyme-linked immunosorbent assay for the determination of S-antigen concentration in whole-virion inactivated adsorbed coronavirus vaccines
Authors: Oksanich A. S. , Krasko A. G. , Samartseva T. G. , Gasich E. L. , Ignatyev G. M. 
Published: December 2022

The severe consequences and high mortality of COVID-19 prompted the development of a wide range of preventive vaccines. The first vaccines to be tested were developed in China and formulated as inactivated SARS-CoV-2 adsorbed on aluminium hydroxide. One of the quality indicators for inactivated adsorbed vaccines is the degree of adsorption, which can be used to control the content not only of non-adsorbed antigen, but also of specific antigen in one dose of a vaccine.The aim of the study was to investigate the possibility of desorbing SARS-CoV-2 antigen from formulated adsorbed vaccines and the possibility of measuring its concentration using the BioScan-SARS-CoV-2 (S) ELISA kit for SARS-CoV-2 S-protein content determination.Materials and methods: the study used four batches of BBIBP-CorV by CNBG, Sinopharm (China) and three batches of CoronaVac by Sinovac Biotech (China). The authors desorbed SARS-CoV-2 S antigen in accordance with monograph FS.3.3.1.0029.15 of the State Pharmacopoeia of the Russian Federation (Ph. Rus.), edition XIV, and quantified it using the BioScan-SARS-CoV-2 (S) ELISA kit by Bioservice Biotechnology Co. Ltd. (Russia).Results: mean S-antigen concentrations in the desorbed samples ranged from 61 to 129 ng/mL for BBIBP-CorV and from 461 to 533 ng/mL for CoronaVac.Conclusions: the study demonstrated the possibility of specific SARS-CoV-2 antigen desorption from the surface of aluminium hydroxide using the Ph. Rus. method, as well as the possibility of S-antigen quantification in desorbed medicinal products and supernatants using the BioScan-SARS-CoV-2 (S) ELISA kit. The authors observed 3.6- to 8.7-fold difference between the S-antigen concentrations of the desorbed preparations by the two manufacturers.
Immunogenicity evaluation of Gam-COVID-Vac (Sputnik V)
Authors: Kirillov I. A. , Pirozhkov A. P. , Rubtsov V. V. , Loginova S. Ya. , Saifulina N. A. , Plekhanova T. M. , Timofeev M. A. , Kutaev D. A. , Logunov D. Y. , Gintsburg A. L. , Borisevich S. V. 
Published: December 2022

In November 2020, the Armed Forces of the Russian Federation began mass immunisation of the personnel with Gam-COVID-Vac (Sputnik V), the first Russia vaccine against the new coronavirus infection (COVID-19). Thus, it became necessary to assess post-vaccination antibody levels and the duration and intensity of humoral immunity to COVID-19.The aim of the study was to investigate the immunogenicity and efficacy of Gam-COVID-Vac in military medical staff after vaccination.Materials and methods: the authors determined the presence of specific antibodies in the serum of individuals immunised with Gam-COVID-Vac (477 volunteers) and COVID-19 convalescents (73 patients), using virus neutralisation (VN), enzyme-linked immunosorbent assay (ELISA) with reagent kits by several manufacturers, and immunoblotting. The results of the study were evaluated using analysis of variance.Results: VN detected virus neutralising antibodies in 90.7% of vaccinated subjects; ELISA, in 95.4%. Both VN and ELISA showed lower antibody levels in the vaccinated over 50 years of age. ELISA demonstrated a significantly higher concentration of anti-SARS-CoV-2 spike IgG in the Gam-COVID-Vac group than in the COVID-19 convalescent group. The correlation between antibody detection results by VN and ELISA was the strongest when the authors used their experimental reagent kit for quantitative detection of virus neutralising antibodies by competitive ELISA with the recombinant human ACE2 receptor. Having analysed the time course of neutralising antibody titres, the authors noted a significant, more than two-fold decrease in geometric means of the titres three months after administration of the second vaccine component.Conclusions: the subjects vaccinated with Gam-COVID-Vac gain effective humoral immunity to COVID-19. The decrease in titres indicates the need for revaccination in 6 months.
Safety of Pharmacotherapy in COVID-19 Patients: A Literature Review
Authors: Kryukov A. V. , Zhiryakova A. S. , Shevchuk Yu. V. , Matveev A. V. , Vechorko V. I. , Averkov O. V. , Glagolev S. V. , Temirbulatov I. I. , Mirzaev K. B. , Denisenko N. P. , Abdullaev Sh. P. , Sychev D. A. 
Published: December 2022

The safety of COVID-19 pharmacotherapy is a relevant issue, first of all, because of the current lack of experience with using particular medicinal products and with off-label prescribing. The aim of the study was to analyse information on potential adverse drug reactions (ADRs) and their predictors in etiology- and pathogenesis-oriented COVID-19 therapy. According to literature data, the main clinically significant risk factors for COVID-19 patients to develop an ADR are the duration of their hospital stay, combined use of antivirals, polypharmacy, and their history of drug allergies. The most common adverse reactions to antivirals, to virus-neutralising antibodies, and to human anti-COVID-19 immunoglobulin and convalescent plasma are, respectively, gastrointestinal and hepatobiliary disor ders; gastrointestinal disorders, neurological disorders, and allergic reactions; and transfusion reactions (fever, chills, etc.). For pathogenesis-oriented therapy with systemic glucocorticosteroids, the most characteristic ADR is hyperglycaemia. Janus kinase inhibitors and interleukin inhibitors are most often associated with gastrointestinal disorders and hypertransaminasemia; neutropenia is also characteristic of a number of interleukin inhibitors. Haemo static adverse reactions to anticoagulants depend on the patient’s dosing regimen and condition. Drug-drug interactions are a common problem in COVID-19 treatment, with the combination of nirmatrelvir and ritonavir showing the largest number of significant interactions attributed to their pharmacokinetics. Currently, there is data on the role of pharmacogenetic biomarkers in the safety and clinical outcomes of COVID-19 therapy. Thus, to improve the safety of COVID-19 therapy, an integrated approach is needed that will take into account both the clinical, demographic, and pharmacogenetic predictors of ADRs and the risk of drug-drug interactions.
Experience of Using Remdesivir in Patients with Novel Coronavirus Infection
Authors: Petrov V. I. , Ryazanova A. Yu. , Privaltseva N. S. , Nekrasov D. A. 
Published: December 2022

Timely, effective, and safe antiviral therapy in COVID-19 patients reduces complications, disability and mortality rates. The greatest concern with remdesivir is the risk of drug-induced liver injury, including in patients whose liver function is compromised by COVID-19.The aim of the study was to investigate the efficacy and safety of remdesivir in patients with confirmed SARS-CoV-2 infection who had been admitted to an infectious diseases hospital in the Volgograd region in March 2022. Materials and methods: the authors carried out an open, non-randomised, single-arm study using medical records of 234 patients who had been diagnosed with “U07.1 COVID-19, virus identified” and prescribed remdesivir upon admission. The effectiveness of therapy was evaluated using two criteria: the need for oxygen supplementation or ventilatory support, or mortality. The authors conducted the evaluation on days 7, 14, and 28 using the six-point ordinal severity scale by Y. Wang et al. The safety of therapy was assessed on the basis of complaints and changes in laboratory findings.Results: for the patients prescribed remdesivir at admission, the 7-day mortality rate was 3.0%, the 14-day mortality rate was 5.6%, and the 28-day mortality rate was 7.3%. With the exception of a patient with myocardial infarction, all the patients who had been hospitalised with mild COVID-19 and prescribed remdesivir did not require oxygen therapy and/or transfer to intensive care and were discharged following recovery. The patients with moderate to severe COVID-19 had the 14-day mortality rate of 6.4% and the 28-day mortality rate of 8.6%. 17 patients (7.2%) discontinued remdesivir prematurely for various reasons, including adverse drug reactions. Remdesivir therapy of 5-10 days was associated with an increase in ALT activity by 2.7 ± 0.8 times in 15.9% of patients with mild COVID-19, by 3.8 ± 1.8 times in 20.4% of patients with moderately severe COVID-19, and by 4.8 ± 2.7 times in 24% (12/50) of patients with severe COVID-19. In two patients (0.9%), the increase exceeded 10-fold the upper limit of normal.Conclusions: the obtained results support recommending remdesivir to patients with mild, moderate and severe COVID-19, including those with moderately elevated baseline activity of hepatic transaminases.
Take No Prisoners Caricature: Nikolai Remizov and the Revolution of 1905
Authors: Levitt Marcus C. 
Published: December 2022

Abstract
This article examines the brilliant caricatures by Nikolai Vladimirovich Remizov (Re-mi, born Vasil’ev, 1887–1975) for the Russian satirical journals of 1905–1907. This period marked the first stage of Remizov’s long career, when he emerged as one of the country’s most talented and well-known caricaturists. The article focuses on Remizov’s new, no-holds-barred satire depicting episodes of state-sponsored bloodletting. The satirical journals widely quoted the words of Dmitri Trepov to his troops during the October general strike “not to fire blanks and to spare no cartridges,” a phrase that became a tragi-comic mantra in the satirical journals. It also reflected the take-no-prisoners spirit of Remizov’s caricatures. Further, the article outlines Remizov’s subsequent participation in the few journals—in particular, Satirikon and Novyi Satirikon (New Satyricon)—that strove to keep the satirical tradition of 1905 alive. After the Bolshevik Revolution put a forcible end to these publications, Remizov emigrated, and later forged a long career in the United States as an art designer for stage, television and the big screen.
Physiological Illustration and a Women’s Fashion Magazine: Vasilii Timm’s Satirical Cartoons in Listok dlia svetskikh liudei, 1843–1844
Authors: Raykhlina Yelizaveta 
Published: December 2022

Abstract
The women’s fashion magazine Listok dlia svetskikh liudei (1839–1845) printed satirical lithographs by the Russo-Baltic artist Vasilii Fedorovich Timm in 1843–1844, providing an important forum for merging the physiological sketch with the fashion press. Listok presented Timm with a serialized format, whereby his satirical cartoons adapted the physiological sketch to a largely female readership, commenting on courtship, relationships, male vices, as well as social ills, urban life, and the state of journalism in the 1840s. Listok offered visual commentary on issues important to female readers as well as broader observations of Petersburg life and Russian society.