bluuebunny/crossref_metadata_2025_split huggingface dataset:
Working on connective professionalism: What cross-sector strategists in Swedish public organizations do to develop connectivity in addressing ‘wicked’ policy problems
Authors: Kanon Miranda , Andersson Thomas 
Published: February 2023

Abstract
In light of current debates on ‘protective’ and ‘connective’ professionalism, this article explores a new type of occupational position that is emerging within the Swedish public sector: the cross-sector strategist. The growing presence of this intermediary occupational position is seen as attempts to formalize and institutionalize the imprecise roles and governance of ‘wicked’ policy problems, and the job of these strategists is focused on supporting other jurisdictions to meet and act. By pursuing connective strategies in the form of triggering, selling, bridging, brokering, and forming accountabilities, cross-sector strategists seek to establish embedded workspaces where strategic action and decisions can be produced jointly and across jurisdictional boundaries. The study illustrates how calls for changes in professional action towards connectivity are now part of the formal organizational structure of public sector organizations, confirming the incapability of professional actors to connect in the absence of intermediary support functions. In the concluding discussion, we consider the relevance of ‘connective professionalism’ as a descriptive theoretical device applied to work settings understood as increasingly complex and interdependent, with calls for inter-professional collaboration and intensifying engagement in preventing problems rather than simply treating them.
Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part I: Mammary gland and digestive tract
Authors: Suzuki Keiji , Imaoka Tatsuhiko , Tomita Masanori , Sasatani Megumi , Doi Kazutaka , Tanaka Satoshi , Kai Michiaki , Yamada Yutaka , Kakinuma Shizuko 
Published: February 2023

Abstract
While epidemiological data are available for the dose and dose-rate effectiveness factor (DDREF) for human populations, animal models have contributed significantly to providing quantitative data with mechanistic insights. The aim of the current review is to compile both the in vitro experiments with reference to the dose-rate effects of DNA damage and repair, and the animal studies, specific to rodents, with reference to the dose-rate effects of cancer development. In particular, the review focuses especially on the results pertaining to underlying biological mechanisms and discusses their possible involvement in the process of radiation-induced carcinogenesis. Because the concept of adverse outcome pathway (AOP) together with the key events has been considered as a clue to estimate radiation risks at low doses and low dose-rates, the review scrutinized the dose-rate dependency of the key events related to carcinogenesis, which enables us to unify the underlying critical mechanisms to establish a connection between animal experimental studies with human epidemiological studies.
Microwave response to kink oscillations of a plasma slab
Authors: Kaltman Tatyana I , Kupriyanova Elena G 
Published: February 2023

ABSTRACT
The modulation of the intensity of microwave emission from a plasma slab caused by a standing linear kink fast magnetoacoustic wave is considered. The slab is stretched along a straight magnetic field, and can represent, for example, a current sheet in a flaring active region in corona of the Sun, or a streamer or pseudostreamer stalk. The plasma density is non-uniform in the perpendicular direction and described by a symmetric Epstein profile. The plasma parameter β is taken to be zero, which is a good approximation for solar coronal active regions. The microwave emission is caused by mildly relativistic electrons which occupy a layer within the oscillating slab and radiate via the gyrosynchrotron (GS) mechanism. Light curves of the microwave emission were simulated in the optically thin part of the GS spectrum, and their typical Fourier spectra were analysed. It is shown that the microwave response to a linear kink magnetohydrodynamic wave is non-linear. It is found that, while the microwave light curves at the node oscillate with the same frequency as the frequency of the perturbing kink mode, the frequency of the microwave oscillations at the antinode is two times higher than the kink oscillation frequency. Gradual transformation the one type of the light curves to another occurs when sliding from the node to the antinode. This result does not depend on the width of the GS-emitting layer inside the oscillating slab. This finding should be considered in the interpretation of microwave quasi-periodic pulsations in solar and stellar flares.
Characterization of inpaint residuals in interferometric measurements of the epoch of reionization
Authors: Pagano Michael , Liu Jing , Liu Adrian , Kern Nicholas S , Ewall-Wice Aaron , Bull Philip , Pascua Robert , Ravanbakhsh Siamak , Abdurashidova Zara , Adams Tyrone , Aguirre James E , Alexander Paul , Ali Zaki S , Baartman Rushelle , Balfour Yanga , Beardsley Adam P , Bernardi Gianni , Billings Tashalee S , Bowman Judd D , Bradley Richard F , Burba Jacob , Carey Steven , Carilli Chris L , Cheng Carina , DeBoer David R , de Lera Acedo Eloy , Dexter Matt , Dillon Joshua S , Eksteen Nico , Ely John , Fagnoni Nicolas , Fritz Randall , Furlanetto Steven R , Gale-Sides Kingsley , Glendenning Brian , Gorthi Deepthi , Greig Bradley , Grobbelaar Jasper , Halday Ziyaad , Hazelton Bryna J , Hewitt Jacqueline N , Hickish Jack , Jacobs Daniel C , Julius Austin , Kariseb MacCalvin , Kerrigan Joshua , Kittiwisit Piyanat , Kohn Saul A , Kolopanis Matthew , Lanman Adam , La Plante Paul , Loots Anita , MacMahon David Harold Edward , Malan Lourence , Malgas Cresshim , Malgas Keith , Marero Bradley , Martinot Zachary E , Mesinger Andrei , Molewa Mathakane , Morales Miguel F , Mosiane Tshegofalang , Neben Abraham R , Nikolic Bojan , Nuwegeld Hans , Parsons Aaron R , Patra Nipanjana , Pieterse Samantha , Razavi-Ghods Nima , Robnett James , Rosie Kathryn , Sims Peter , Smith Craig , Swarts Hilton , Thyagarajan Nithyanandan , van Wyngaarden Pieter , Williams Peter K G , Zheng Haoxuan 
Published: February 2023

ABSTRACTTo mitigate the effects of Radio Frequency Interference (RFI) on the data analysis pipelines of 21 cm interferometric instruments, numerous inpaint techniques have been developed. In this paper, we examine the qualitative and quantitative errors introduced into the visibilities and power spectrum due to inpainting. We perform our analysis on simulated data as well as real data from the Hydrogen Epoch of Reionization Array (HERA) Phase 1 upper limits. We also introduce a convolutional neural network that is capable of inpainting RFI corrupted data. We train our network on simulated data and show that our network is capable of inpainting real data without requiring to be retrained. We find that techniques that incorporate high wavenumbers in delay space in their modelling are best suited for inpainting over narrowband RFI. We show that with our fiducial parameters discrete prolate spheroidal sequences (dpss) and clean provide the best performance for intermittent RFI while Gaussian progress regression (gpr) and least squares spectral analysis (lssa) provide the best performance for larger RFI gaps. However, we caution that these qualitative conclusions are sensitive to the chosen hyperparameters of each inpainting technique. We show that all inpainting techniques reliably reproduce foreground dominated modes in the power spectrum. Since the inpainting techniques should not be capable of reproducing noise realizations, we find that the largest errors occur in the noise dominated delay modes. We show that as the noise level of the data comes down, clean and dpss are most capable of reproducing the fine frequency structure in the visibilities.
Gas clumping and its effect on hydrostatic bias in the MACSIS simulations
Authors: Towler Imogen , Kay Scott T , Altamura Edoardo 
Published: February 2023

ABSTRACT
We use the MACSIS hydrodynamical simulations to estimate the extent of gas clumping in the intracluster medium of massive galaxy clusters and how it affects the hydrostatic mass bias. By comparing the clumping to the azimuthal scatter in the emission measure, an observational proxy, we find that they both increase with radius and are larger in higher mass and dynamically perturbed systems. Similar trends are also seen for the azimuthal temperature scatter and non-thermal pressure fraction, both of which correlate with density fluctuations, with these values also increasing with redshift. However, in agreement with recent work, we find only a weak correlation between the clumping, or its proxies, and the hydrostatic mass bias. To reduce the effect of clumping in the projected profiles, we compute the azimuthal median following recent observational studies, and find this reduces the scatter in the bias. We also attempt to correct the cluster masses by using a non-thermal pressure term and find overcorrected mass estimates (1 − b = 0.86 to 1 − b = 1.15) from 3D gas profiles but improved mass estimates (1 − b = 0.75 to 1 − b = 0.85) from projected gas profiles, with the caveat of systematically increased scatter. We conclude that the cluster-averaged mass bias is minimized from applying a non-thermal pressure correction (1 − b = 0.85) with more modest reductions from selecting clusters that have low clumping (1 − b = 0.79) or are dynamically relaxed (1 − b = 0.80). However, the latter selection is most effective at minimizing the scatter for individual objects. Such results can be tested with next-generation X-ray missions equipped with high-resolution spectrometers such as Athena.
The abundance of z ≳ 10 galaxy candidates in the HUDF using deep JWST NIRCam medium-band imaging
Authors: Donnan C T , McLeod D J , McLure R J , Dunlop J S , Carnall A C , Cullen F , Magee D 
Published: February 2023

ABSTRACTWe utilize JWST NIRCam medium-band imaging to search for extreme redshift (z ≥ 9.5) galaxy candidates in the Hubble ultra deep field (HUDF) and the additional pointing within the GOODS-South field provided by the second NIRCam module. Our search reveals six robust candidates, three of which have recently been spectroscopically confirmed. One of these three is the previously controversial z ≃ 12 galaxy candidate UDF-22980 which is now detected in five JWST NIRCam medium-band filters (F182M, F210M, F430M, F460M, and F480M), efficiently excluding alternative low-redshift solutions and allowing us to now report a secure photometric redshift of zphot = 11.6 ± 0.2. We also detect two galaxies at z ≥ 12.5 including a newly-detected candidate in the imaging provided by the second NIRCam module (south-west of the HUDF) at zphot = 12.6 ± 0.6. We determine the physical properties of the six galaxies by fitting the 14-band photometry with Bagpipes. We find stellar masses of log (M⋆/M⊙) ≃ 7.5−8.7 and star-formation rates of $\log (\rm {SFR}/M_{\odot }^{-1} \rm {yr}^{-1}) \simeq 0.3 - 5.0$. Despite the relatively small cosmological volume covered by the HUDF itself and the second NIRCam module imaging, we find that the existence of these galaxies is fully consistent with the latest measurements of both the ultraviolet luminosity function and cosmic star-formation rate density at z ≃ 11, supporting a gradual steady decline in the cosmic star-formation rate density out to at least z ≃ 15.
Evolution of rotating 25 M⊙ Population III star: physical properties and resulting supernovae
Authors: Aryan Amar , Pandey Shashi Bhushan , Gupta Rahul , Ror Amit Kumar 
Published: February 2023

ABSTRACT
In this letter, we report the outcomes of 1D modelling of a rotating 25 M⊙ zero-age main sequence Population III (Pop III) star up to the stage of the onset of core collapse. Rapidly rotating models display violent and sporadic mass-losses after the main-sequence stage. In comparison to the solar metallicity model, Pop III models show very small pre-supernova radii. Further, with models at the stage of the onset of core collapse, we simulate the hydrodynamic simulations of resulting supernovae. Depending upon the mass-losses due to corresponding rotations and stellar winds, the resulting supernovae span a class from weak Type II to Type Ib/c. We find that the absolute magnitudes of the core-collapse supernovae resulting from Pop III stars are much fainter than that resulting from a solar metallicity star. From our simulation results, we also conclude that within the considered limits of explosion energies and nickel masses, these transient events are very faint, making it difficult for them to be detected at high-redshifts.
HaploBlocks: Efficient Detection of Positive Selection in Large Population Genomic Datasets
Authors: Kirsch-Gerweck Benedikt , Bohnenkämper Leonard , Henrichs Michel T , Alanko Jarno N , Bannai Hideo , Cazaux Bastien , Peterlongo Pierre , Burger Joachim , Stoye Jens , Diekmann Yoan 
Published: February 2023

AbstractGenomic regions under positive selection harbor variation linked for example to adaptation. Most tools for detecting positively selected variants have computational resource requirements rendering them impractical on population genomic datasets with hundreds of thousands of individuals or more. We have developed and implemented an efficient haplotype-based approach able to scan large datasets and accurately detect positive selection. We achieve this by combining a pattern matching approach based on the positional Burrows–Wheeler transform with model-based inference which only requires the evaluation of closed-form expressions. We evaluate our approach with simulations, and find it to be both sensitive and specific. The computational resource requirements quantified using UK Biobank data indicate that our implementation is scalable to population genomic datasets with millions of individuals. Our approach may serve as an algorithmic blueprint for the era of “big data” genomics: a combinatorial core coupled with statistical inference in closed form.
Chryseochelins—structural characterization of novel citrate-based siderophores produced by plant protecting Chryseobacterium spp.
Authors: Rehm Karoline , Vollenweider Vera , Gu Shaohua , Friman Ville-Petri , Kümmerli Rolf , Wei Zhong , Bigler Laurent 
Published: February 2023

Abstract
Bacteria secrete siderophores whose function is to acquire iron. In recent years, the siderophores of several Chryseobacterium species were shown to promote the health and growth of various plants such as tomato or rice. However, the chemical nature of Chryseobacterium siderophores remained unexplored despite great interest. In this work, we present the purification and structure elucidation by nuclear magnetic resonance (NMR) spectroscopy and tandem mass spectrometry (MS/MS) of chryseochelin A, a novel citrate-based siderophore secreted by three Chryseobacterium strains involved in plant protection. It contains the unusual building blocks 3-hydroxycadaverine and fumaric acid. Furthermore, the unstable structural isomer chryseochelin B and its stable derivative containing fatty acid chains, named chryseochelin C, were identified by mass spectrometric methods. The latter two incorporate an unusual ester connectivity to the citrate moiety showing similarities to achromobactin from the plant pathogen Dickeya dadantii. Finally, we show that chryseochelin A acts in a concentration-dependent manner against the plant-pathogenic Ralstonia solanacearum strain by reducing its access to iron. Thus, our study provides valuable knowledge about the siderophores of Chryseobacterium strains, which have great potential in various applications.
Recipient UvrD helicase is involved in single- to double-stranded DNA conversion during conjugative plasmid transfer
Authors: Shen Minjia , Goldlust Kelly , Daniel Sandra , Lesterlin Christian , Yamaichi Yoshiharu 
Published: February 2023

AbstractDissemination of antibiotic resistance, a current societal challenge, is often driven by horizontal gene transfer through bacterial conjugation. During conjugative plasmid transfer, single-stranded (ss) DNA is transferred from the donor to the recipient cell. Subsequently, a complete double-stranded (ds) plasmid molecule is generated and plasmid-encoded genes are expressed, allowing successful establishment of the transconjugant cell. Such dynamics of transmission can be modulated by host- or plasmid-encoded factors, either in the donor or in the recipient cell. We applied transposon insertion sequencing to identify host-encoded factors that affect conjugative transfer frequency in Escherichia coli. Disruption of the recipient uvrD gene decreased the acquisition frequency of conjugative plasmids belonging to different incompatibility groups. Results from various UvrD mutants suggested that dsDNA binding activity and interaction with RNA polymerase are dispensable, but ATPase activity is required for successful plasmid establishment of transconjugant cells. Live-cell microscopic imaging showed that the newly transferred ssDNA within a uvrD− recipient often failed to be converted to dsDNA. Our work suggested that in addition to its role in maintaining genome integrity, UvrD is also key for the establishment of horizontally acquired plasmid DNA that drives genome diversity and evolution.
Hepatotoxicity from high-dose methotrexate in primary central nervous system lymphoma
Authors: Zhang Joy C , Stotts Matthew J , Horton Bethany , Schiff David 
Published: February 2023

Abstract

Background
High-dose methotrexate (HDMTX) is a mainstay of primary central nervous system lymphoma (PCNSL) treatment. Transient hepatotoxicity from HDMTX has been characterized in pediatric patients but not in adults. We sought to characterize hepatotoxicity in adult PCNSL patients undergoing HDMTX treatment.

Methods
Retrospective study of 65 PCNSL patients treated at the University of Virginia from 02/01/2002 to 04/01/2020 was performed. Hepatotoxicity was defined using National Cancer Institute Common Toxicity Criteria (CTC) for adverse events, fifth version. High-grade hepatotoxicity was defined as a bilirubin or aminotransferase CTC grade of 3 or 4. Relationships between clinical factors and hepatotoxicity were assessed with logistic regression.

Results
Most patients (90.8%) had a rise of at least one aminotransferase CTC grade during HDMTX treatment. 46.2% had high-grade hepatotoxicity based on aminotransferase CTC grade. No patients developed high-grade bilirubin CTC grades during chemotherapy. Liver enzyme test values decreased to low CTC grade or normal in 93.8% of patients after the conclusion of HDMTX treatment without treatment regimen changes. Prior ALT elevation (P = .0120) was a statistically significant predictor of high-grade hepatotoxicity during treatment. Prior history of hypertension was associated with increased risk of toxic serum methotrexate levels during any cycle (P = .0036).

Conclusions
Hepatotoxicity develops in the majority of HDMTX-treated PCNSL patients. Transaminase values decreased to low or normal CTC grades in almost all patients after treatment, without modification of MTX dosage. Prior ALT elevation may predict patients’ increased hepatotoxicity risk, and hypertension history may be a risk factor for delayed MTX excretion.
Wages of UK immigrant men across generations: who catches up?
Authors: Ochmann Nico 
Published: February 2023

Abstract
This article examines UK immigrant-native wage differentials for men across major first- and second-generation immigrant groups with the UK Household Longitudinal Study (UKHLS) pooling cross-sections over the years 2009–19. I find that first-generation immigrants with UK human capital experience less of a wage disadvantage than their immigrant counterparts with foreign language proficiency, qualifications, and work experience. Conditional on the heterogeneity in these productivity characteristics of first-generation immigrants, I observe no intergenerational economic progress across the two generations relative to UK natives. Using a conditional decomposition shows that UK work experience and not the source country of study for the qualification is a key factor in reducing first-generation, immigrant-native wage differentials in the UK.
First photometric investigation of OGLE-SMC-ECL-2063: A low-metallicity massive contact binary in the SMC
Authors: Wu Chuqi , Qian Shengbang , Li Fuxing , Zejda Miloslav , Mikulásek Zdeněk , Zhu Liying , Liao WenPing , Zhao Ergang 
Published: February 2023

Abstract
Studying massive binaries in different evolution stages or environments may help us to solve the problem of the evolution of massive binaries. The metallicity in the Small Magellanic Cloud (SMC) is much lower than that in our Milky Way, and binaries in the SMC are rarely studied. OGLE-SMC-ECL-2063 is a short-period early-type binary with a period of ${0{_{.}^{\circ}}6317643}$ in the SMC. We use the Wilson–Devinney code to analyze its light curves. The result shows that OGLE-SMC-ECL-2063 is an overcontact binary with a high mass ratio of 0.900 and a fill-out factor of $35.9\%$. The O − C curves of the period of OGLE-SMC-ECL-2063 show a long-term increase with a cyclic oscillation of amplitude A = 0.00503 d and period P3 = 14.80 yr. All the evidence above indicates that OGLE-SMC-ECL-2063 is in the Case A mass transfer evolutionary state. The mass transfer rate $\dot{M}_2 = -5.67 \times 10^{-7} M_{\odot }\:$yr−1 is derived and used to explain the continuous period increase. Because both components of OGLE-SMC-ECL-2063 are early-type stars, the existence of a third body may be the reason for the cyclic change in period. The mass of the third body is derived to be no less than 0.70 M⊙ and the orbital separation to be no more than 13.22 au. Combining the result of light-curve analysis, the third body tends to be a low-mass late-type star. Such high-mass-ratio binaries play an important role in the evolution of early-type binaries. Thus, researching OGLE-SMC-ECL-2063 provides the basis for us to study the formation and evolution of early-type contact binaries.
Deposit Insurance Premiums and Bank Risk
Authors: Kim Edward T , Rezende Marcelo 
Published: February 2023

AbstractDeposit insurance premiums impose costs on banks’ balance sheets, narrowing profit margins and inducing banks to “search for yield.” This paper estimates the effects of deposit insurance premiums on bank portfolio rebalancing using supervisory data and a kink in the insurance premium schedule. We show that deposit insurance premiums weaken banks’ demand for reserves (a liquid asset with no credit risk) and strengthen the supply of short-term interbank loans (a less liquid asset with credit risk). We discuss the implications of these findings for optimal deposit insurance pricing. (JEL G21, G28)