bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erectile dysfunction in patients with liver cirrhosis; upper Egypt experience
Authors: Haridy Mustafa Ahmed , Mohamed Mohamed Fakhry , Badr Ahmed Fathy , Mekky Mahmoud AbdelSabour , Abdelmola Omran Mohamed , Mohammedin Emad Abdelrazzak , Sawy Safwat Salama , El-Nady Mohammed Ali Ahmed , Agamy Maha Mohamed , Ead Khalid Abdelazeem , Mostafa Hamdy Mahfouz 
Published: January 2023

Abstract
Background

normal sexual activity is an important issue in the quality of life for both males and females. Several diseases were associated with erectile dysfunction, unfortunately, data about erectile dysfunction in cirrhotic patients was scanty. This study was conducted to determine the prevalence and risk factors of erectile dysfunction in patients with liver cirrhosis.

Method: a

cross-sectional study was conducted on 200 patients with liver cirrhosis they were divided into three groups according to Child score and erectile dysfunction was studied by (IIEF-5) Questionnaire and penile Doppler.

Results

the prevalence of erectile dysfunction in the cirrhotic patient was 80%. the erectile dysfunction worsens with the worsening of the liver condition (Child C), also 20% of the cirrhotic patients had penile venous leakage which became 28.6% in advance liver cirrhosis (Child C). Multivariate logistic regression showed that advancing in age, Albumin less than 2.8 g/dl, INR 1.7-2.2, Hb>16 g/dl and Child C were predictors of erectile dysfunction in cirrhotic patients.

Conclusion

Erectile dysfunction was found in 80% of cirrhotic patients. It was more frequently observed in cirrhotic patients having an advanced disease (child C). Patients reporting ED had elevated INR, serum bilirubin, suppressed serum albumin, and elevated level of hemoglobin.
WITHDRAWN: Green HRM and Green Innovation
Authors: Bancea Alexandru , Chan Jeff , Cartwright-Johnson Shawn , Muszynski Philip 
Published: January 2023

Abstract

We examined the relationships between green transformational leadership, green innovation, and environmental performance via the lens of green human resource management, taking a resource-based perspective and applying the ability-motivation-opportunity hypothesis. Using a questionnaire, we were able to collect tetradic data from 309 SMEs in the manufacturing industry (SMEs). To do so, we used structural equation modeling (SEM) with a covariance emphasis to evaluate our assumptions. The results indicate that green human resource management strategies mediate the connection between green transformational leadership and green innovation. We also found that green HRM has an indirect effect on a company's environmental performance through green innovation. All of our assumptions about both direct and indirect effects were confirmed, and our findings have numerous theoretical and practical implications. Finally, our study contributes significantly to theory by showing that the HRM-performance relationship depends on a combination of the additive and interactive effects of green transformational leadership and green innovation as antecedent and mediator, respectively, on firm environmental performance. In sum, our study contributes to the existing body of literature by building upon the notion that leadership significantly affects HRM practices, which in turn predicts green innovation in the workplace.
Anti-scaling performances of different aged landfill leachates on PPR and ABS pipe materials
Authors: Zhao Rui , Chen Jingfang , Liu Jie , Li Min , Yang Hongwei 
Published: January 2023

Abstract
Landfill leachate, because of its complex components, may cause pipe clogging during its collection and transportation, and pose a threat to the environment. This study considers two typical drainage pipe materials, i.e., polypropylene-random (PPR) and acrylonitrile-butadiene-styrene (ABS), to discriminate their anti-scaling performances through a landfill leachate immersion experiment. The results show that both PPR and ABS pipe materials immersed in the younger-aged leachate are prone to scaling. The mass concentrations of Ca2+ in the leachate play a key role in scale formation, followed by Mg2+, pH, oxidation–reduction potential (ORP), dissolved oxygen (DO), and Cl−. In particular, Ca2+, pH, and DO show a positive relationship in scaling, while Mg2+ acts in a negative relationship. Calcium carbonate is the major constituent of the scales, accounting for 72.3% of the total. The scaling on the surface of the PPR pipe material is more serious than that of the ABS pipe material, revealed by the corresponding weight increment that is 33% higher than that related to ABS during the experimental period. It is thus indicated that ABS has better anti-scaling performance, which may be an optional material selected for the system design of leachate collection and transportation.
Standing waves of the stepped dropshaft in a deep tunnel stormwater system
Authors: Sun Jingkang , Qian Shangtuo , Xu Hui , Chen Yaohui , Ren Weichen 
Published: January 2023

Abstract
The deep tunnel stormwater system, consisting of dropshafts and underground tunnels, is used to alleviate or prevent urban water problems associated with extreme rainfall events. The stepped dropshaft can transport surface runoff to the tunnels with high energy dissipation, low risk of cavitation and good exhaust performance, which well meets the requirement of the deep tunnel stormwater system. In the present study, the characteristics of the standing wave were investigated by experiments and numerical simulations, including the peak, trough and length of the standing wave. The flow regimes were divided into the nappe flow, the transition flow and the skimming flow with the increase of discharge, in which the standing wave mainly occurs on the external wall under the nappe flow and the transition flow. Influences of inflow discharge and dropshaft geometries were analyzed, including step rotation angle, relative step height and dropshaft curvature. The relations of the characteristics of standing wave with these effect factors were obtained. The maximum discharge capacity of the stepped dropshaft was established by considering that the standing wave just reached the above steps, which could be useful for the design and safe operation of the stepped dropshaft.
Preparation of environment-friendly SiO2 aerogel based on waste boron mud and its adsorption behavior for toluene
Authors: Liu Yue , Zhang Tonglu , Wang Bai , Hu Jianshe 
Published: January 2023

AbstractTo mitigate the environmental hazards of boron mud waste accumulation, we prepared environmental-friendly SiO2 aerogels by extracting them through alkaline leaching treatment and optimized the experimental conditions. The optimum process parameters for alkaline leaching solution NaOH concentration, leaching temperature, solid-to-liquid ratio, and leaching time were 2 mol/L, 95 °C, 1:4, and 3 h, respectively. In this work, cheap and non-toxic hydroxy silicone oil (PDMS–OH) and hydrogen-containing silicone oil (PMHS) were used as surface modifiers instead of toxic and expensive trimethylchlorosilane (TMCS) in the SiO2 aerogel modification process. The best performance under the optimum conditions was achieved with 60% PDMS–OH-modified SiO2 aerogel. Organic liquid spills, represented by toluene, pose a great danger to the environment and water bodies. We treated free toluene on the water surface with the aerogel mentioned above and its adsorption capacity was up to 2,655 mg/g. After the adsorption of toluene, the aerogels coalesced into agglomerates for subsequent collection and handling. Furthermore, after five repeated applications, the adsorption capacity remained at 91.43% of the initial application. Overall, this research provided an inexpensive and simple solution for the treatment of organic liquids in wastewater.
Fish Protein Hydrolysates: Bioactive Properties, Encapsulation and New Technologies
for Enhancing Peptides Bioavailability
Authors: Moya Moreira Thaysa Fernandes , Gonçalves Odinei Hess , Leimann Fernanda Vitória , Ribeiro Ricardo Pereira 
Published: January 2023

Abstract:
Fish protein hydrolysates (FPHs) can be obtained from substrates such as fish muscle, skin, and
wastes and assign value to these fish by-products. Proteolytic enzymes catalyze the hydrolysis of these fish substrates'
peptide bonds resulting in smaller peptides that present several bioactive properties. Hydrolysates' bioactive
properties are a function of the fish species used as the substrate, the enzyme selectivity or specificity, pH
and temperature applied in the reaction, etc. Furthermore, many pre-treatment methods are being applied to fish
protein substrates to improve their enzyme susceptibility and increase the number of smaller bioactive peptides.
This review addresses the production of FPHs and the main bioactive properties evaluated recently in the literature
and emphasizes the substrate treatments by high-pressure processing, microwave, ultrasound, and thermal
treatments to achieve better bioactivity making essential amino acids more available in peptides. The bioactive
properties most found in FPHs were antioxidants, antimicrobials, anticancer, and antihypertensive. These bioactivities
may vary depending on the conditions of hydrolysis, fish species, and fractionation and isolation of specific
peptides.New technologies for the treatment of by-products can reduce process losses and achieve better
results by cleavage of proteins. Conversely, encapsulation and film utilization can improve bioactivity, bioavailability,
and controlled release when applied to foods, resulting in improved health.
Liposomal Formulation Improves the Bioactivity of Usnic Acid in RAW
264.7 Macrophage Cells Reducing its Toxicity
Authors: Vasarri Marzia , Ponti Linda , Degl'Innocenti Donatella , Bergonzi Maria Camilla 
Published: January 2023

Background:
Reactive oxygen species (ROS) production and oxidative stress may be responsible
for the onset of several chronic diseases. Usnic acid (UA) is a natural secondary metabolite of
lichens with several healthful bioactivities, including antioxidant properties. However, UA is a hydrophobic
compound known for its hepatic toxicity. These aspects limit its therapeutic applications. To
overcome these drawbacks and improve the pharmacological use of hydrophobic compounds, nanotechnology
is widely used. Therefore, the incorporation of UA into appropriate nanocarriers could enhance
the bioactivity of UA by increasing its solubility.

Objective:
The aim of this work was to improve the solubility of UA and its bioactivity in the absence
of cytotoxicity.

Methods:
In this study, UA loaded liposomes (UA-LP) were developed. The formulations were chemically
and physically characterized, and an in vitro release study was performed. Free UA and UA-LP
were tested on RAW 264.7 murine macrophages in terms of cytotoxicity, intracellular ROS production,
and NO release in the absence or presence of pro-oxidant LPS stimulus.

Results:
UA-LP showed excellent physical and chemical stability during storage and improved solubility
of UA. UA-LP showed an antioxidant effect in the absence of cytotoxicity compared with free UA
on LPS-exposed macrophages.

Conclusion:
For the first time, liposomal formulation improved the beneficial action of UA in terms of
solubility and antioxidant activity.
Negami: An Augmented Reality App for the Treatment of Spatial Neglect After Stroke
Authors: Stammler Britta , Flammer Kathrin , Schuster Thomas , Lambert Marian , Karnath Hans-Otto 
Published: January 2023

Background
A widely applied and effective rehabilitation method for patients experiencing spatial neglect after a stroke is “visual exploration training.” Patients improve their ipsilesional bias of attention and orientation by training exploration movements and search strategies toward the contralesional side of space. In this context, gamification can have a positive influence on motivation for treatment and thus on the success of treatment. In contrast to virtual reality applications, treatment enhancements through augmented reality (AR) have not yet been investigated, although they offer some advantages over virtual reality.

Objective
This study aimed to develop an AR-based app (Negami) for the treatment of spatial neglect that combines visual exploration training with active, contralesionally oriented rotation of the eyes, head, and trunk.

Methods
The app inserts a virtual element (origami bird) into the real space surrounding the patient, which the patient explores with the camera of a tablet. Subjective reports from healthy elderly participants (n=10) and patients with spatial neglect after stroke (n=10) who trained with the new Negami app were analyzed. Usability, side effects, and game experience were assessed by various questionnaires.

Results
Training at the highest defined difficulty level was perceived as differently challenging but not as frustrating by the group of healthy elderly participants. The app was rated with high usability, hardly any side effects, high motivation, and entertainment. The group of patients with spatial neglect after stroke consistently evaluated the app positively on the dimensions of motivation, satisfaction, and fun.

Conclusions
The Negami app represents a promising extension by adding AR to traditional exploration training for spatial neglect. Through participants’ natural interaction with the physical surrounding environment during playful tasks, side effects as symptoms of cybersickness are minimized and patients’ motivation appeared to markedly increase. The use of AR in cognitive rehabilitation programs and the treatment of spatial neglect seems promising and should receive further investigation.
ALPHA-GLUCOSIDASE INHIBITOR ACTIVITIES AND PHYTOCHEMICALS SCREENING OF THE PEPEROMIA GENUS CULTIVATED IN INDONESIA
Authors: SAEPUDIN SYUMILLAH , SUSILAWATI YASMIWAR 
Published: January 2023

Objective: Peperomia is a genus belong to Piperaceae family, which is valuable as ornamental and has several medical uses but not widely explored in their pharmacological activities. Some peperomia plant has been investigated and reported to have various activities, recently as diabetes mellitus. This research was conducted to screening phytochemical profile and to determine alpha-glucosidase inhibitor activities of five species in genus Peperomia that are easy to grow and has been cultivated in Indonesia.
Methods: Dried leaves were macerated with 70% ethanol and vaporized by rotary evaporator. Phytochemical screening was conducted using qualitative chemical analysis and inhibition of alpha-glucosidase was conducted using p-nitrophenyl-α-D-glucopyranoside as substrate, and absorbance was measured with a spectrophotometer UV-Vis.
Results: The phytochemical screening of the leaves extracts demonstrated the presence of various secondary metabolites, such as flavonoids, phenol, tannins, quinone, alkaloids, saponins, steroids, and triterpenoids. The inhibition of alpha-glucosidase showed that the IC50 value of ethanol extract of P. obtusifolia, P. clusiifolia, P. caperata (green), P. caperata (red), and P. argyreia leaves were 2.90; 18.05; 21.46; 23.81; and 48.70 µg/ml respectively.
Conclusion: The highest inhibition of alpha-glucosidase activity was showed by P. obtusifolia with an IC50 value of 2.90 µg/ml. Further research is needed to explore its potential as an antidiabetic.
GC-MS PROFILE AND ANTIBACTERIAL ACTIVITY OF ESSENTIAL OIL FROM STROBILANTHES KALIMANTANENSIS LEAVES: A NEW SPECIES FROM EAST KALIMANTAN, INDONESIA
Authors: PRABOWO WISNU CAHYO , NARSA ANGGA CIPTA , ANDARISTA DZAKI BAYU , KUNCORO HADI , KUSUMA SRI AGUNG FITRI , SUSILAWATI YASMIWAR 
Published: January 2023

Objective: The aim was to determine the botanical, GC-MS chemical characteristics and antibacterial activity of Strobilanthes. kalimantanensis as a new species.
Methods: Characterization of plants through microscopic and macroscopic analysis, isolation of essential oil (EO) by steam distillation, GC-MS analysis of essential oil content and antibacterial effectiveness tests.
Results: The results of the steam distillation process of essential oil produced yield 0.547%, clear and has fresh scent. GC-MS results from essential oils identified major phytochemicals, including anethole and estragole. Antibacterial activity of EO is 100 mg/ml against Staphylococcus aureus and 150 mg/ml against Bacillus subtilis, Escherichia coli, and Streptococcus epidermidis.
Conclusion: Plant with the first species reported as Strobilanthes kalimantanensis contains essential oils that have antibacterial activity.
BOMBAX CEIBA LINN: A CRITICAL REVIEW ON PHYTOCHEMISTRY, TRADITIONAL USES, PHARMACOLOGY, AND TOXICITY FROM PHYTOPHARMACEUTICAL PERSPECTIVE
Authors: GUPTA NIRAJ , SHARMA DEVENDER , RANI REKHA 
Published: January 2023

Traditional medicines are becoming crucial and decisive role in the prevention and cure of diseases and disorders. Traditional medicines have various pharmacological activities which important for human health. Bombax Ceiba widely used from past decades for the treatment of diseases and disorders. Bombax ceiba is usually referred to as kapok tree and moca, which belongs to Bombacaceae. Moca is a crucial medicative, plant widely found in a tropical and subtropical Asian country like India, Pakistan. Various scientific studies or medicative usage has been reported within the traditional systems of drugs like Ayurveda, Siddha and Unani. Owing to this widespread attention about traditional medicines, scientific validations of medicinal plants have become a thrust area of research. In this paper, the scientific validation of Bombax ceiba for various biological activities has been reviewed with its chemical constituents present in the whole plant and with its traditional and contemporary uses. This manuscript also provides deep inside of recent patents associated with Bombax ceiba in the past decade.
“Citādāks reps” vai “kristīgā glance”: Dievs un pasaule Latvijas kristīgajā repā
Authors:   Latvijas Universitāte, Andrejevs Ņikita 
Published: January 2023

Historically, Christian rap emerged in the context of Evangelical Christianity in the US. Since its birth in the 1970s, it has been often represented as a tool for evangelization and outreach in the modern urban environment. Although there are stories of purported success of these attempts, most US Christian rappers have since turned to Christians as their primary audiences. There are two main attitudes towards the world and its culture among Christian rappers that are manifest in their approach to the style of their songs. Nevertheless, the general attitude towards the world and culture in Christian rap is that of distancing from these aspects, and Christian rappers want to transform or educate the faithless society, Thereby denying the world its capacity to acquire genuine meaning and truth without Christian assistance. There is a discussion on terminology for engaging Christian rap from an academic perspective. Although some Christian rap scholars prefer to use a definition such as “Christians and hip-hop” to include all the possible interactions of Christians, rappers, and hip-hop culture, throughout the article the studied phenomenon is called “Christian rap” to distance the study of the actual rap lyrics and theology they contain from the analysis of hip-hop beats, breakdance, graffiti and/or other elements of hip-hop culture. This problem with definition mirrors the discussion common to the study of Contemporary Christian music genres, where there is debate on the question of criteria that can be employed to define “Christian music”. Latvian Christian rap represents an array of attitudes towards the world. There are examples of “worship rap” or separational approach to Contemporary Christian music and examples of integrational approach. These two approaches represent different attitudes towards the world, although fundamentally all Latvian Christian rappers that are mentioned in the article distance themselves from the world and wish to enlighten it or reach the faithless with their appropriation of popular contemporary music. Latvian Christian rap is a marginal phenomenon because it struggles with acceptance in Christian circles as much as among non-Christians that are to be its main and desired audience. Rap and hip-hop are perceived to be connected to protest, violence, drugs and other things that are foreign to the image of Christianity in Latvia.
Catholic Encounters in Jack Kerouac’s “Lonesome Traveler” and Lowell Novels
Authors:   Latvijas Universitāte, Stikāne Ilze 
Published: January 2023

Amerikāņu rakstnieks Džeks Keruaks dzīves laikā interesējās par dažādām reliģiskajām tradīcijām, vislielāko uzmanību līdzās budismam pievēršot kristietībai. Rakstā analizēti Keruaka ceļojumu rakstu krājumā Lonesome Traveler atrodamie baznīcu apmeklējumu apraksti un salīdzināti ar Louelas romāniem, kuru notikumi balstīti pilsētā, kurā Keruaks uzauga. Šie teksti liecina par gadījumiem, kad Keruaks vai viņa varoņi, apmeklējot baznīcas, gūst emocionālus pārdzīvojumus vai pat mistiskas pieredzes. Caur šīm pieredzēm Keruaks un viņa varoņi atkal un atkal atgriežas pie Jēzus Kristus un viņa piemēra. Keruaks savos ceļojumos nebūtu uzlūkojams kā svētceļnieks vai tūrists – viņa aprakstos pietrūkst iepriekšēja nodoma, kas to apstiprinātu. Drīzāk viņa īstenotajiem baznīcu apmeklējumiem piemīt spontāna daba, kas raksturo arī to laikā gūtās autentiskās pieredzes. Šādās situācijās, kas apcerētas grāmatā Lonesome Traveler, sastapšanās ar katolicismu Keruakam atgādina par viņa ģimenes praktizēto reliģiju un par Jēzus nozīmi. Šis atgādinājums tālāk izraisa ilgas pēc mājām, kur būtu iespējamas nepārtrauktas personiskas attiecības ar Dievu, kādas tās ir attēlotas Louelas romānos.
Glucagon Prescribing and Costs Among U.S. Adults With Diabetes, 2011–2021
Authors: Herges Joseph R. , Galindo Rodolfo J. , Neumiller Joshua J. , Heien Herbert C. , Umpierrez Guillermo E. , McCoy Rozalina G. 
Published: January 2023

OBJECTIVETo characterize contemporary trends in glucagon fill rates and expenditures in a nationwide cohort of adults with diabetes overall and by key demographic and clinical characteristics.RESEARCH DESIGN AND METHODSIn this retrospective cohort study, we examined 1) glucagon fill rates per 1,000 person-years and 2) patient out-of-pocket and health plan costs per filled glucagon dose among adults with diabetes included in OptumLabs Data Warehouse between 1 January 2011 and 31 March 2021.RESULTSThe study population comprised 2,814,464 adults with diabetes with a mean age of 62.8 (SD 13.2) years. The overall glucagon fill rate decreased from 2.91 to 2.28 per 1,000 person-years (−22%) over the study period. In groups at high risk for severe hypoglycemia, glucagon fill rates increased from 22.46 to 36.76 per 1,000 person-years (64%) among patients with type 1 diabetes, 11.64 to 16.63 per 1,000 person-years (43%) among those treated with short-acting insulin, and 16.08 to 20.12 per 1,000 person-years (25%) among those with a history of severe hypoglycemia. White patients, women, individuals with high income, and commercially insured patients had higher glucagon fill rates compared with minority patients, males, individuals with low income, and Medicare Advantage patients, respectively. Total cost per dosing unit increased from $157.97 to $275.32 (74%) among commercial insurance beneficiaries and from $150.37 to $293.57 (95%) among Medicare Advantage beneficiaries.CONCLUSIONSGlucagon fill rates are concerningly low and declined between 2011 and 2021 but increased in appropriate subgroups with type 1 diabetes, using short-acting insulin, or with a history of severe hypoglycemia. Fill rates were disproportionately low among minority patients and individuals with low income.