bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die „Hölle“ bezeugen
Authors: Löw Andrea 
Published: January 2023

Abstract
Im Herbst 1941 begann die systematische Deportation der deutschen Jüdinnen und Juden „nach Osten“. Einer der Zielorte war Riga; zwischen dem 27. November 1941 und dem 6. Februar 1942 fuhren zwanzig Transporte mit insgesamt etwa 20.000 Menschen zum Güterbahnhof Riga-Skirotava. Die Insassen des ersten Transports aus Berlin erschossen SS- und Polizeikräfte direkt nach der Ankunft, die Menschen in den folgenden Zügen gelangten an verschiedene Orte in und bei Riga: das Lager Jungfernhof, das Getto von Riga und das Lager Salaspils. Unmittelbar nach dem Krieg zeichneten manche Überlebende auf, wie sie nach der Deportation an Orten überlebt hatten, die sie zuweilen als „die Hölle“ bezeichneten. Einige dieser Zeugnisse sind hier dokumentiert.
MYB sustains hypoxic survival of pancreatic cancer cells by facilitating metabolic reprogramming
Authors: Anand Shashi , Khan Mohammad Aslam , Zubair Haseeb , Sudan Sarabjeet Kour , Vikramdeo Kunwar Somesh , Deshmukh Sachin Kumar , Azim Shafquat , Srivastava Sanjeev Kumar , Singh Seema , Singh Ajay Pratap 
Published: January 2023

AbstractExtensive desmoplasia and poor vasculature renders pancreatic tumors severely hypoxic, contributing to their aggressiveness and therapy resistance. Here, we identify the HuR/MYB/HIF1α axis as a critical regulator of the metabolic plasticity and hypoxic survival of pancreatic cancer cells. HuR undergoes nuclear‐to‐cytoplasmic translocation under hypoxia and stabilizes MYB transcripts, while MYB transcriptionally upregulates HIF1α. Upon MYB silencing, pancreatic cancer cells fail to survive and adapt metabolically under hypoxia, despite forced overexpression of HIF1α. MYB induces the transcription of several HIF1α‐regulated glycolytic genes by directly binding to their promoters, thus enhancing the recruitment of HIF1α to hypoxia‐responsive elements through its interaction with p300‐dependent histone acetylation. MYB‐depleted pancreatic cancer cells exhibit a dramatic reduction in tumorigenic ability, glucose‐uptake and metabolism in orthotopic mouse model, even after HIF1α restoration. Together, our findings reveal an essential role of MYB in metabolic reprogramming that supports pancreatic cancer cell survival under hypoxia.
Del turco al árabe
Authors: Petit Lorenza 
Published: January 2023

El estudio pretende investigar el vínculo que Bárbara Jacobs y Jorge Asís, autores latinoamericanos de origen árabe, mantienen, en su producción narrativa, con el mundo medio oriental de sus ancestros. El análisis se dirige a la representación del migrante árabe y su reconstrucción como respuesta al discurso orientalista presente en la literatura latinoamericana. De tal forma, el “árabe” se (re)incorpora, como elemento cultural, al imaginario latinoamericano y convierte a los autores en agentes culturales en México y Argentina. El objetivo es demonstrar que, los nietos de estos flujos migratorios hacen patente, en sus textos, un cambio de discurso que contrarresta la imagen de Oriente y del migrante como inmutable e inamovible.
Calidad de vida de los cafeticultores en las Altas Montañas de Veracruz, México
Authors: Gasperín-García Erika M. , Platas-Rosado Diego Esteban , Zetina-Córdoba Pedro , Vilaboa-Arroniz Julio , Dávila Francisco Marcos 
Published: January 2023

Introducción. La Región de las Altas Montañas (RAMVER) es la de mayor importancia productiva y socioeconómica para el cultivo del café del estado de Veracruz, México y una de las más representativas del sector a nivel nacional. Objetivo. Determinar la calidad de vida (CV) desde el punto de vista objetivo y subjetivo de los pequeños productores (PP) de café en la RAMVER, México. Materiales y métodos. Se aplicaron 150 entrevistas semiestructuradas a productores en once municipios ubicados en: Comapa, Coscomatepec, Huatusco, Ixhuatlán del café, Sochiapa, Tenampa, Tomatlán, Totutla, Tlaltetela, Tlacotepec y Zentla, durante el año 2020. Se obtuvo estadística descriptiva y medidas de tendencias central. Resultados. En el nivel objetivo, la CV se encontró baja, pero en el nivel subjetivo de los agricultores, se determinó como aceptable. En la valoración objetiva se identificó que los PP tienen educación mínima (primaria), el ingreso no es el adecuado (requieren realizar alguna actividad extra a la agrícola con un ingreso promedio anual neto de US $ 416 a US $1115); el costo de la salud se incrementó (por pandemia COVID-19) y se carece de una alimentación apropiada (19 a 25 comidas por mes). En la valoración subjetiva existe inseguridad y desconfianza con las autoridades gubernamentales, sin embargo, los productores se han adaptado a vivir en contextos socioeconómicos adversos, ya que valoran la vida en comunidad, las relaciones intrafamiliares y su entorno (la cafeticultura), esto pudiese estar influenciado por su propia cosmovisión. Conclusiones. Con o sin conocimiento sobre el concepto de calidad, los productores han desarrollado una capacidad aprendida o adquirida en lo individual y en lo colectivo para adaptarse al entorno. A nivel objetivo, la calidad de vida se consideró como baja, no obstante, los entrevistados tuvieron una percepción de satisfacción tanto en lo individual como en lo colectivo.
Galangin inhibits lipopolysaccharide-induced inflammation and stimulates osteogenic differentiation of bone marrow mesenchymal stem cells via regulation of AKT/mTOR signaling
Authors: Xiaoting Wang  , Xiao Xinglei 
Published: January 2023

Background: Bone marrow mesenchymal stem cells (BMSCs), with the abilities of multidirec-tional differentiation and self-renewal, have been widely used in bone repair and regeneration of inflammation-stimulated oral diseases. Galangin is a flavonoid isolated from Alpinia officinarum, exerts anti-obesity, antitumor, and anti-inflammation pharmacological effects. The roles of galangin in lipopolysaccharide-induced inflammation and osteogenic differentiation of BMSCs were investigated.
Methods: BMSCs were isolated from rat bone marrow and identified by flow cytometry. The isolated BMSCs were treated with 1 μg/mL lipopolysaccharides or cotreated with lipopolysaccharides and different concentrations of galangin. Cell viability and apoptosis were detected by MTT (tetrazolium component) and flow cytometry. ELISA was used to detect inflammation. Alizarin red staining was used to investigate osteogenic differentiation.
Results: The rat BMSCs showed negative rate of CD34, and positive rate of CD29 and CD44. Lipopolysaccharides treatment reduced cell viability of BMSCs, and promoted the cell apoptosis. Incubation with galangin enhanced cell viability of lipopolysaccharide-stimulated BMSCs, and suppressed the cell apoptosis. Galangin decreased levels of TNF-α, IL-1β, and IL-6 in lipo-polysaccharide-stimulated BMSCs through down-regulation of NF-κB phosphorylation (p-NF-κB). Galangin up-regulated expression of osteo-specific proteins, collagen type I alpha 1 (COL1A1), osteopontin (OPN), and runt-related transcription factor 2 (RUNX2), to promote the osteogenic differentiation of lipopolysaccharide-stimulated BMSCs. Protein expression of p-AKT and p-mTOR in lipopolysaccharide-stimulated BMSCs were increased by galangin treatment.
Galangin exerted an anti-inflammatory effect against lipopolysaccharide-stimulated BMSCs and promoted osteogenic differentiation through the activation of AKT/ mTOR signaling.
An Analysis of Ethiopian Federal TVET Institute Trainees’ Academic and Professional Needs of the English Language
Authors: Zeleke Ephrem , Arficho Zeleke , Mulatu Mebratu 
Published: January 2023

The present study was intended to analyze the Ethiopian Federal TVET Institute trainees’ academic and professional needs of the English language and its relevance to their needs. In the study, descriptive design was employed and data collection tools, namely close-ended questionnaires, semi-structured interviews and content analysis were used. Eighty trainees and 30 former graduates were included using simple random sampling technique to fill in questionnaires and for interviews two major course trainers and two former graduates among those who filled in the questionnaires were selected using the same sampling technique, and all the available (4) Communicative English Skills course instructors were included. Moreover, Communicative English Skills I and II course materials/modules were also analyzed to examine the relevance of the courses to meet the trainees’ academic and professional needs. The questionnaires data were analyzed quantitatively and qualitative data were analyzed using thematic data analysis methods. The study showed that reading technical course books, lecture handouts and examination papers, taking lecture notes, writing organized paragraphs concisely, exam answers, term papers and researches, presenting project reports and seminars orally in the classroom, and listening to lectures and technical conversations are the most frequently needed English sub-skills by the trainees. The findings also showed that most of the language contents are not compatible with the trainees’ English language needs. Thus, the teaching material currently in use lacks topical/thematic relevance to the trainees’ fields of study in almost all the units. The findings might have implications for ESP material developers and course designers.
Perceptions of Postgraduates Majoring in English Education on Speaking Assessment Module for Online Distance Learning (ODL)
Authors: Fahrughazi Syazwin , Omar Halizah , Mohamad Maslawati 
Published: January 2023

Assessment of speaking skills differs from other language skills. The methods of conducting speaking skills are included in the English Assessment Module developed by the researchers from the National University of Malaysia (UKM). The module is designed to cater postgraduates (adult learners) through Online Distance Learning (ODL) program. ODL has become essential in education setting for adult learners as they could manage their learning whilst juggling their career and personal commitments. The covid-19 pandemic has become the starting point for postgraduates to conduct the course remotely according to their preferences of learning. The revolution of education allows adult learners to pursue their Masters. The module includes various types of English language assessments in the context of speaking English as a Second Language (ESL). Hence, eight adult learners were interviewed to give their perceptions towards this newly designed module. This qualitative research method employed a set of semi-structured interview questions and open-ended questions via Google Meet. The findings showed that English Assessment Module; Speaking Assessment is well equipped with comprehensive information and guidelines on how the speaking assessments should be conducted in ESL context. Generally, the findings indicate that the English Assessment Module; Speaking Assessment is suitable for ODL postgraduates (adult learners). This paper also includes the participants’ suggestions to further improve the module. The findings could benefit the online distance course designers in designing better module for adult learners and enable the learners to learn effectively at their own convenience.
Diversidad de lepidópteros diurnos en un área de bosque seco tropical del occidente antioqueño
Authors: Orozco Silvia , Muriel Sandra B. , Palacio Jorge 
Published: January 2023

Los paisajes rurales albergan muchas especies silvestres y complementan la estrategia de conservación en las áreas naturales protegidas. Esta investigación se planteó dos preguntas: a) ¿Cual es la diversidad de mariposas diurnas de la granja del Politécnico JIC?, b) ¿De las especies encontradas qué proporción han sido referenciadas como indicadoras de bosques? Se dividió la granja en cinco zonas, en las cuales se realizaron once muestreos durante doce meses. Se determinó la diversidad esperada a través de estimadores no-paramétricos y se comparó la diversidad por zonas con el análisis de agrupamiento Chi-cuadrado. Se colectaron 933 individuos, que representaron 117 especies y seis familias: Nymphalidae (78), Pieridae (18), Hesperiidae (6), Riodinidae (6), Papilionidae (5) y Lycaenidae (4). Las especies nectarívoras más abundantes fueron Anartia amathea, Anartia jatrophae y Mechanitis menapsis, de las especies frugívoras capturadas, la única abundante fue Pareuptychia hesione. Un 23% de las especies pertenecen a subfamilias relacionadas con paisajes poco intervenidos. La diversidad esperada fue de 158 especies y este estudio encontró el 74% de ella. Las zonas presentaron baja similitud en las especies, la mayor diversidad y abundancia se presentó en las zonas uno y dos, posiblemente debido a la mayor abundancia de plantas ornamentales y arvenses forecidas todo el año. La presencia de especies típicas de sitios poco intervenidos indicaría que los parches de bosque de la granja son importantes en la provisión de recursos para las mariposas o como ruta de paso hacia parches de bosque mayores en este paisaje.
Detailed evaluation of site-response estimation methods across and along the sedimentary valley of volvi (EURO-SEISTEST)
Authors: Riepl J. , Bard P.-Y. , Hatzfeld D. , Papaioannou C. , Nechtschein S. 
Published: January 2023

AbstractUsing records from the EURO-SEISTEST area near Thessaloniki (Greece), we studied empirically the amplification effects of a sedimentary valley. One of the main advantages of this site is the very detailed knowledge of the near-subsurface structure due to exhaustive geophysical and geotechnical measurements and data analyses (Jongmans et al., 1998). The uniqueness of the seismological data set is the very dense network: 31 stations were installed perpendicular and parallel to the valley axis, with minimum interstation distances of 250 m. The mean amplifications along both axes, estimated from 13 local events, were imaged using the traditional spectral ratio technique. Variations of the mean amplifications due to the choice of different data subsets were tested by the use of up to 89 local events, supplemented by four teleseismic events offering good low-frequency resolution. Results obtained using the traditional spectral ratio technique were compared with results from a generalized inversion technique, the H/V ratio technique, a coda wave technique, and Nakamura's technique. Advantages and disadvantages of each method are outlined, especially from a practical point of view.
In-vitro investigation of primary stability of orthodontic mini implants with different lengths using resonance frequency analysis
Authors: Chandak Amruta Mantri , Tarvade Suchita Daokar , Sharma Mitali , Kaurani Harsha Jairaj 
Published: January 2023

Out of various ways of gaining anchorage, mini implants are gaining attention due to its minimum compliance and maximum curative effects.Mini implants are considered successful if they have sufficient primary stability that comes from mechanical interlocking of mini implant with the bone.Factors which influence the implant stability are bone physiology, implant size, shape and surface characteristics. Considering all other factors within anatomic constraints, what may play a role in primary stability of mini implants is length. Literature search to correlate mini implant length with primary stability was found to be insufficient and hence this study was undertaken. In this study, two goat jaws were subjected to spiral 3D CT scan and the areas with D2 bone density were identified and marked. In these D2 density marked areas, 30 implants of 1.5 x 6mm (GROUP A) and 30 implants of 1.5 x8mm (GROUP B) were placed. Their stability was measured by Radio Frequency Analysis using Osstell ISQ device with its Smart Peg. A connector was fabricated to make the fit of smart peg compatible with the head of mini implant. Readings were made in 5 different directions for each implant and their average value was considered as final reading. It was noted that primary mini implant stability is significantly higher (p 0.034) with GROUP B implants than with GROUP A implants. The increased length of mini-implants positively affects its primary stability and should be taken into consideration when implants are used as anchorage devices.
Effect of rapid maxillary expander with posterior bite blocks in hyperdivergent patients with adenoid hypertrophy- A cephalometric study
Authors: Soni Deepak Mohan , Negi K.S. , Azad Ramesh , Sood Sankalp , Chainta Dimple , Negi Nishant 
Published: January 2023

To analyze the effect of Rapid Maxillary Expansion (RME) with posterior bite blocks on craniofacial structures in hyperdivergent patients with adenoid hypertrophy and to compare them with control group. 32 patients of adenoid hypertrophy (mean age 11.6 yrs, range 8-12 years) with a transverse discrepancy were selected and divided into two groups in a random way - Group A: (n=16) hyrax RME with posterior bite block group, Group B: (n=16) control group. Group A- Lateral and Posteroanterior cephalograms were recorded pretreatment (T0), postexpansion (T1), and after 9 months retention (T2). Group B- Lateral and Posteroanterior cephalograms were recorded pretreatment (T0), and after 9 months (T2) concurrent with Group A. Cephalometric measurements in sagittal, vertical and transverse dimensions were taken and comparison was made using Paired and Unpaired t-test with p &#60; 0.05 as statistically significant. Group A underwent insignificant increase in SN-MP angle whereas it increased significantly in Group B. The lower facial height and jarabak’s ratio decreased significantly. All transverse parameters increased significantly with maximum increase in intermolar width when compared with Group B. Significant increase in the transverse dimensions of mid face occurs with RME thus increasing the upper airway patency and effective control of the vertical growth pattern, typical of adenoid hypertrophy, was seen in the treatment group when compared with the control group.
Study of Drug Utilization Pattern during Second Wave of Covid-19 in a Tertiary Care Centre: A Retrospective Cross Sectional Study
Authors: Gawali Ujwala P. , Gurung Aruna 
Published: January 2023

Background: To study the drug utilization trends among patients with COVID-19 disease during the second wave in a tertiary care hospital.
Methods: A retrospective cross-sectional study was conducted in patients admitted in COVID-19 wards during second wave of SARS – COVID-19 pandemic from 1st March 2021 to 30th June 2021. A total of 300 prescriptions were analysed. Assessment of prescription patterns were done as per the WHO-The International Network for Rational Use of Drugs (INRUD)drug use indicators.
Results: A total of 3106 drugs were analysed.The average number of drugs prescribed was 11±5.1. The most frequent prescription was that of analgesic and antipyretic drug Paracetamol (95.26%) followed by vitamin C (94.74%) and multivitamins(87.89%) . Nearly all patients in this study received antibacterials, 68% received antivirals. Antibacterials commonly used were cephalosporins, amoxicillin- clavulanic acid combination and pipercillin –tazobactam combination. Antiviral drug Remdesivir was also used extensively in our study (54.21%). Other class of drugs which were commonly prescribed to more patients were Dalteparin (73.16%) and corticosteroids like methyl prednisolone (52.63%) and dexamethasone (51.05%). 35.68% of the drugs were prescribed with generic name .45.43% of the drugs were injectables . 2.96% of the drugs were prescribed as fixed dose combinations.
Conclusion: In summary, the drug utilization for hospitalized patients with COVID-19 was diverse but generally complied with the ongoing guidelines. The drug were mostly prescribed from WHO essential drug list and percentage of fixed dose combination prescription was low. However not prescribing the drugs by generic name and large encounters of injectable was matter of concern. To get a better glimpse of drug utilization a more extensive study needs to be undertaken.
Correlation between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study
Authors: Khani Elnaz , Khoshbaten Manouchehr , Pourkarim Fariba , Asghari Jafarabadi Mohammad , Shaseb Elnaz 
Published: January 2023

Background: Non-alcoholic fatty liver disease (NAFLD) is one of the important health issues with high prevalence worldwide. However, there is no approved medication for that. As one of the indicators of metabolic syndrome, uric acid might play a role in the pathogenesis of NAFLD. In this study, we aimed to determine the correlation between serum uric acid level, liver enzymes, and ultrasonographic grading of NAFLD.
Methods: This cross-sectional study included patients aged 18-65 with NAFLD. Patients with other metabolic disorders and a history of using alcohol or medications that alter uric acid levels were excluded. The patients' serum uric acid, alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels, and ultrasonographic grading of NAFLD at baseline, third month, and sixth month were collected.
Results: Of the 3000 patients, 500 patients met the eligibility criteria. The results showed that there is a significant positive relationship between ALT and serum uric acid level at the first (P= 0.01), third (P=0.01), and sixth month (P=0.01). Furthermore, there was a significant positive correlation between AST and serum uric acid level at the sixth month (P= 0.001). The comparison of 249 patients' ultrasonographic grading showed no significant correlation with serum uric acid levels.
Conclusion: To conclude, the serum uric acid level significantly correlates with ALT and AST over six months but not with the ultrasonographic grading. Further studies are required to determine the role of uric acid-lowering agents in the treatment of NAFLD.
Experimental Simulation of a Tennis Ball using Wind Tunnel
Authors: Souza Cesar Almiro de , Campos Julio Cesar Costa , Siqueira Antonio Marcos de Oliveira , Treto Pedro Casanova , Tibiriça Alvaro Messias Bigonha , Rosa Henrique Márcio Pereira , Brito Rogério Fernandes 
Published: January 2023

In this study, tennis balls were analyzed experimentally through the use of a wind tunnel with speed ranging from 1m/s to 14 m/s, which is a variation in the Reynolds number (10,000 < Re < 60,000). In this context, aerodynamic aspects of the balls were evaluated, including the position of the seam and the degree fuzz, i.e., with and without fuzz. It was possible to analyze the effect of drag on the diameter, in the investigation of the relationship between the drag coefficient (CD) and the Reynolds number (Re) for new and used balls. Graphics were generated using the Reynolds number and the Drag Coefficient in order to assess the (non) dependency of these parameters. In the measurements performed, the static balls inside the wind tunnel were considered, i.e., without rotation. Therefore, no discussions about the Magnus force are presented. The results obtained, ? 3 to ? 0.60, were consistent for the range of the Reynolds number investigated. High values are expected for the drag coefficient, to the range of Reynolds number examined. The position of the seam, according to the related literatures, is negligible to high values of Reynolds, i.e., Re >50,000. On the other hand, for low values of Reynolds number, it can represent a difference of up to about 9% for the CD. The balls without fluff showed the strongest influence of the position of the seam, which characterizes the influence of this parameter. The effect of fuzz seemed to be responsible for about 10% of the total drag for low values of the Reynolds number. The diameter variation was analyzed alone.