bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of nonlinear mixed‐effects continuous‐time models using the continuous‐discrete extended Kalman filter
Authors: Ou Lu , Hunter Michael D. , Lu Zhaohua , Stifter Cynthia A. , Chow Sy‐Miin 
Published: September 2023

AbstractMany intensive longitudinal measurements are collected at irregularly spaced time intervals, and involve complex, possibly nonlinear and heterogeneous patterns of change. Effective modelling of such change processes requires continuous‐time differential equation models that may be nonlinear and include mixed effects in the parameters. One approach of fitting such models is to define random effect variables as additional latent variables in a stochastic differential equation (SDE) model of choice, and use estimation algorithms designed for fitting SDE models, such as the continuous‐discrete extended Kalman filter (CDEKF) approach implemented in the dynr R package, to estimate the random effect variables as latent variables. However, this approach's efficacy and identification constraints in handling mixed‐effects SDE models have not been investigated. In the current study, we analytically inspect the identification constraints of using the CDEKF approach to fit nonlinear mixed‐effects SDE models; extend a published model of emotions to a nonlinear mixed‐effects SDE model as an example, and fit it to a set of irregularly spaced ecological momentary assessment data; and evaluate the feasibility of the proposed approach to fit the model through a Monte Carlo simulation study. Results show that the proposed approach produces reasonable parameter and standard error estimates when some identification constraint is met. We address the effects of sample size, process noise variance, and data spacing conditions on estimation results.
The decline in kidney function after heart transplantation and its impact on survival
Authors: Chaemchoi Tasigan , Ittiwattanakul Wannee , Ritteeverakul Puangpen , Intrarakamhang Ai‐lada , Thammanatsakul Kanokwan , Sinphurmsukskul Supanee , Siwamogsatham Sarawut , Puwanant Sarinya , Ariyachaipanich Aekarach 
Published: September 2023

AbstractBackgroundEvidence of decline in native renal function after heart transplantation (HTx) in the Asian population is limited. This study determined the incidence and risk factors associated with declining kidney function after HTx and its impact on survival.MethodsA retrospective study of consecutive adult heart transplant patients was conducted in a single center between 2010 and 2020. The decline in kidney function was defined as the presence of one of the following criteria, including a ≥ 40% decline in eGFR, absolute value <15 mL/min/1.73 m2 (calculated by the CKD‐EPI method), doubling of serum creatinine, or dialysis.ResultsA total of 79 patients (77% male, mean age 44.5 ± 11.53 years, with a mean eGFR at discharge from the heart transplant admission of 87.9 ± 25.48 mL/min/1.73 m2) were included. During the median follow‐up of 42 months, the rate of decline in eGFR was 3.9 mL/min/1.73 m2 per year, with a cumulative probability of decline in kidney function of 22% at 1 year and 43% at 5 years. The need for dialysis was 2.5% at 1 year and 5% at 5 years. The decline in kidney function within 1 year after discharge (hazard ratio (HR), 22.24; p = .007) and pre‐HTx diabetes mellitus (DM) (HR, 8.99; p = .034) were independently associated with the need for dialysis. Post‐HTx dialysis predicted all‐cause mortality (HR, 4.47; p = .017).ConclusionsApproximately 20% of HTx patients developed a decline in kidney function within 1 year after discharge. These individuals and pre‐HTx DM patients needed preventive measures to prevent progression to chronic dialysis, which impacted survival. (thaiclinicaltrials.org number, TCTR20230620004).
Generalized generosity: Lessons from a social and educational organization
Authors: Frémeaux Sandrine , Moneyron Jean‐Didier 
Published: September 2023

AbstractWhile the personal and social benefits of generosity have been demonstrated in sociological studies, little is known about the levers and mechanisms of generosity within organizations. This article explores how members of a social and educational organization can participate in the culture of generosity. Based on an analysis of 89 semi‐structured interviews with members of five different institutions oriented toward youth education, the authors provide insight into the different ways to contribute to disseminating generosity. Our study reveals how certain managerial practices can be effective levers for developing generalized generosity within an educational organization. We also show that each member of this type of organization is assigned specific roles of giver and receiver to enable their participation in the educational project.
Crafting literature reviews worth publishing: Five recommendations
Authors: Michailova Snejina 
Published: September 2023

AbstractCrafting and publishing high‐quality literature reviews is a challenging journey. In this Viewpoint article, I outline what authors should consider when submitting a stand‐alone literature review or a manuscript containing a literature review section to the European Management Review. I focus on five selected themes and offer recommendations to authors. I also address reviewers and editors when relating some of my observations to the “An A is an A” mentality debate.
Structural evolution, dielectric, electric, and energy storage properties of BaTi1‐xLixO3‐3xF3x oxyfluorides
Authors: Li Yumin , Bian Jianjiang 
Published: September 2023

AbstractSintering behavior, structural evolution, dielectric, electric, and energy storage properties of BaTi1‐xLixO3‐3xF3x (x = 0–0.10) oxy fluorides have been investigated by X‐ray diffraction, Raman spectroscopy, scanning electron microscopy (SEM), impedance, and ferroelectric analyzer in this paper. The oxy‐fluoride ceramic (x = .06) could be densified at ∼1000°C/2 h in an N2 atmosphere without reduction of Ti4+. The solid solutions experienced a transformation from a tetragonal phase into a pseudo‐cubic phase at room temperature with increasing doping levels, exhibiting typical relaxor features. Pseudo‐cubic phase with a small amount of residual tetragonal phase could be observed in x = .02, while a trace amount of BaF2 secondary phase appeared, resulting in the formation of oxygen vacancies in the x ≥ 0.08 compositions. Temperature‐dependent Raman analysis of the doped compositions seems to imply the presence of local polar clusters even above the Burns temperature. Insulation of the grain could be improved by appropriate doping of BaLiF3 due to an increase in the band gap, whereas high‐level doping (x > 0.06) leads to a decrease in insulation due to the formation of oxygen vacancies (BaTi0.94‐xLi0.06+xO2.82‐2xF0.18+x). Optimized energy storage properties with recoverable energy density Wrec = 2.92J/cm3, efficiency η = 85%, and breakdown strength (BDS) = 315 kV/cm can be achieved at x = .06 composition. Sintering of BaTi1‐xLixO3‐3xF3x in the ambient atmosphere leads to the deterioration of the dielectric, electric, and energy storage properties compared with the counterpart sintered in N2 due to the formation of F− vacancies (BaTi0.94Li0.06O2.82+xF0.18‐2x).
RETRACTED: Wound infection in robotic‐assisted radical prostatectomy compared with retropubic radical prostate surgery: A meta‐analysis
Authors: Zhu Wei , Wu Lingfeng , Xie Wenhua , Zhang Gaoyue , Gu Yanqin , Hou Yansong , He Yi 
Published: September 2023

AbstractA meta‐analysis investigation was executed to measure the wound infection (WI) in robotic‐assisted radical prostatectomy (RRP) compared with retropubic radical prostate surgery (RRPS). A comprehensive literature investigation till February 2023 was applied, and 1197 interrelated investigations were reviewed. The 19 chosen investigations enclosed 107 153 individuals with prostate cancer (PC) at the starting point. 72 008 of them were utilising RRP, and 35 145 were utilising RRPS. Odds ratio (OR) in addition to 95% confidence intervals (CIs) was utilised to compute the value of the WI in RRP compared with RRPS by the dichotomous approaches and a fixed or random model. RRP had significantly lower surgical site wound infection (SSWI) (OR, 0.33; 95% CI, 0.21–0.52, P < .001) and infected lymphoceles (ILs) (OR, 0.45; 95% CI, 0.22–0.92, P = .03) compared with RRPS in individuals with PC. RRP had significantly lower SSWI and ILs compared with RRPS in individuals with PC. However, care must be exercised when dealing with its values because of the low sample size of some of the nominated investigations for the meta‐analysis.
Enhanced acceptor concentration, proton conductivity, and hydration in multicomponent rare‐earth ortho‐niobates
Authors: Dawczak Arkadiusz , Skubida Wojciech , Mielewczyk‐Gryń Aleksandra , Gazda Maria 
Published: September 2023

AbstractThe structural properties of (La0.2Nd0.2Sm0.2Gd0.2Eu0.2)1−xCaxNbO4−δ (x = 0–0.05) series have been studied by X‐ray powder diffraction at room temperature. The thermal properties were investigated using thermogravimetry, from which the concentration of proton defects was determined. Additionally, dilatometry studies were carried out, from which the thermal expansion coefficients and the phase transition temperature between low‐ and high‐temperature polymorphs were determined. In order to determine the electrical properties, the electrochemical impedance spectroscopy measurements under atmospheres of dry synthetic air and saturated with water vapor and heavy water at 300–800°C temperature range were performed. All the studied materials were single‐phase compositions and were stable in monoclinic I2/c crystal structure at room temperature. The water uptake studies revealed a small mass change under the switch from dry to humidified synthetic air atmospheres, suggesting the formation of proton defects. The phase transition from monoclinic to tetragonal crystal structure in the (La0.2Nd0.2Sm0.2Gd0.2Eu0.2)1−xCaxNbO4−δ (x = 0–0.05) series occurs above 650°C. A small amount of calcium dopant increases the total conductivity in all tested atmospheres by two orders of magnitude, for example, from 0.34 μS cm−1 in La0.2Nd0.2Sm0.2Gd0.2Eu0.2NbO4 to 63.7 μS cm−1 in (La0.2Nd0.2Sm0.2Gd0.2Eu0.2)0.95Ca0.05NbO4−δ at 700°C in humid synthetic air atmosphere.
Synthesis and characterization of Celsian by solid‐state reaction process from mullite
Authors: Guo Tenglong , Li Yuanbing , Li Shujing , Qiao Zhe , Liu Jingfei , Li Xiaoxiao 
Published: September 2023

AbstractMonolithic barium aluminosilicate (Celsian), with good thermal shock resistance, high thermal stability, and strong versatility, is attractive material as a ceramic matrix for high‐temperature composites. However, Celsian cannot be precipitated directly during the synthesis process but can only be generated by crystallographic transformation of the metastable Hexacelsian at high temperatures, and this process is sluggish. In this study, mullite was chosen as the main raw material for the synthesis of Celsian with almost fully monoclinic through a simple one‐step solid‐state reaction process at a lower temperature and shorter time, which was investigated using differential thermal analysis, phase identification, microstructure observation, and FactSage thermodynamic calculations. The results showed that mullite is a favorable raw material for the synthesis of Celsian, effectively avoiding the appearance of BaAl2O4 in Hexacelsia, making it possible to synthesize Celsian with almost fully monoclinic with only 4.5 h of holding at 1300°C. This is a significant improvement compared to the higher temperatures and longer holding times required for the synthesis of Celsian from other raw materials, according to previous literature.
Prevalence and associated factors of chemotherapy‐related cognitive impairment in older breast cancer survivors
Authors: Zhou Xuan , Zhang Xueyan , Zhong Tangsheng , Zhou Meng , Gao Lan , Chen Li 
Published: September 2023

AbstractAimsTo examine the prevalence and associated factors of chemotherapy‐related cognitive impairment (CRCI) in older breast cancer survivors (BCS).DesignSystematic review.Data SourcesWe searched EMBASE, PubMed, PsychInfo, CINAHL, Cochrance Library, Web of Science, CNKI and SinoMed, without language restrictions, for studies published from the establishment of the database to September 2022.Review MethodsTwo researchers independently examined the full texts, data extraction and quality assessment, and any discrepancies were resolved through discussion with a third reviewer. Quality of evidence was assessed using the Newcastle‐Ottawa Scale and the Agency for Healthcare Research and Quality Scale.ResultsThe seven included studies showed that the estimated prevalence of CRCI in older BCS ranged from 18.6% to 27% on objective neuropsychological tests and from 7.6% to 49% on subjective cognitive assessments. The areas most affected were attention, memory, executive functioning and processing speed. CRCI was associated with 10 factors in six categories, including sociodemographic (e.g. age, education level), physiological (e.g. sleep disorders, fatigue and comorbidities), psychological (e.g. anxiety, depression), treatment modalities (e.g. chemotherapy cycles, chemotherapy regimens), genetic (e.g. APOE2, APOE4) and lifestyle factor (e.g. physical inactivity).ConclusionCRCI is multifactorial and has a relatively high prevalence. However, the results of subjective and objective cognitive examinations were inconsistent, possibly due to variations in tools used to evaluate different definitions of CRCI. Nevertheless, as there are few published studies of older BCS, this conclusion still require verification by well‐designed studies in the future.ImpactWe found that the prevalence of CRCI in older adults is relatively high and multifactorial, providing evidence for further health care for this population.No Patient or Public ContributionThere was no patient or public involvement.
Partial ownership, control, and investment in vertical relationships
Authors: Levy Nadav 
Published: September 2023

AbstractThis paper examines whether partial ownership of a trading partner can alleviate hold‐up problems and promote relationship‐specific investments. Unlike a silent financial interest, which does not give the owner control over the partner and promotes both parties' investments, partial control over the partner could reduce the partner's investment and lead the owner to overinvest, thereby decreasing the joint surplus. The inability of the owner to restrain himself from abusing his control limits the effectiveness of partial ownership. An analysis of the control environment should be part of the empirical analysis of partial ownership and the assessment of its potential benefits by competition authorities.
Nodal–paranodal antibodies in HIV‐immune mediated radiculo‐neuropathies: Clinical phenotypes and relevance
Authors: Moodley K. , Patel V. B. , Moodley A. A. , Bill P. L. A. , Kajee A. , Mgbachi V. , Fehmi J. , Rinaldi S. 
Published: September 2023

AbstractBackgroundThe frequency of nodal–paranodal antibodies in HIV‐infected patients with chronic immune‐mediated radiculo‐neuropathies (IMRN) has not been previously described.MethodsHIV‐infected patients who met the inclusion criteria for chronic IMRN were screened for immunoglobulin G (IgG) antibodies directed against nodal (neurofascin (NF)186) and paranodal (NF155, contactin‐1 (CNTN1) and contactin‐associated protein(Caspr1)) cell adhesion molecules, using a live, cell‐based assay.To explore potential pathogenicity, binding of human IgG to myelinated co‐cultures was assessed by incubation with patients' sera positive for nodal or paranodal antibodies. Normal human serum was added as a source of complement to assess for complement activation as a mechanism for myelin injury.ResultsTwenty‐four HIV‐infected patients with IMRN were included in the study, 15 with chronic inflammatory demyelinating polyneuropathy (CIDP), 4 with ventral root radiculopathies (VRR), and 5 with dorsal root ganglionopathies (DRG). Five patients with CIDP had combined central and peripheral demyelination (CCPD). Three patients (12.7%) tested positive for neurofascin IgG1 antibodies in the following categories: 1 patient with VRR was NF186 positive, and 2 patients were NF155 positive with DRG and mixed sensory‐motor demyelinating neuropathy with optic neuritis, respectively.ConclusionThe frequency of nodal–paranodal antibodies is similar among IMRN regardless of HIV status. Interpretation of the results in the context of HIV is challenging as there is uncertainty regarding pathogenicity of the antibodies, especially at low titres. Larger prospective immune studies are required to delineate pathogenicity in the context of HIV, and to establish a panel of antibodies to predict for a particular clinical phenotype.
Reducing brain kynurenic acid synthesis precludes kynurenine‐induced sleep disturbances
Authors: Rentschler Katherine M. , Milosavljevic Snezana , Baratta Annalisa M. , Wright Courtney J. , Piroli Maria V. , Tentor Zachary , Valafar Homayoun , O'Reilly Christian , Pocivavsek Ana 
Published: September 2023

SummaryPatients with neurocognitive disorders often battle sleep disturbances. Kynurenic acid is a tryptophan metabolite of the kynurenine pathway implicated in the pathology of these illnesses. Modest increases in kynurenic acid, an antagonist at glutamatergic and cholinergic receptors, result in cognitive impairments and sleep dysfunction. We explored the hypothesis that inhibition of the kynurenic acid synthesising enzyme, kynurenine aminotransferase II, may alleviate sleep disturbances. At the start of the light phase, adult male and female Wistar rats received systemic injections of either: (i) vehicle; (ii) kynurenine (100 mg kg−1; i.p.); (iii) the kynurenine aminotransferase II inhibitor, PF‐04859989 (30 mg kg−1; s.c.); or (iv) PF‐04859989 and kynurenine in combination. Kynurenine and kynurenic acid levels were evaluated in the plasma and brain. Separate animals were implanted with electroencephalogram and electromyogram telemetry devices to record polysomnography, and evaluate the vigilance states wake, rapid eye movement sleep and non‐rapid eye movement sleep following each treatment. Kynurenine challenge increased brain kynurenic acid and resulted in reduced rapid eye movement sleep duration, non‐rapid eye movement sleep delta power and sleep spindles. PF‐04859989 reduced brain kynurenic acid formation when given prior to kynurenine, prevented disturbances in rapid eye movement sleep and sleep spindles, and enhanced non‐rapid eye movement sleep. Our findings suggest that reducing kynurenic acid in conditions where the kynurenine pathway is activated may serve as a potential strategy for improving sleep dynamics.
Exploring the interaction of viscosity and nipple design on feeding performance in an infant pig model
Authors: Howe Stephen , Steer Kendall , Johnson Maxwell , Adjerid Khaled , Edmonds Chloe , German Rebecca , Mayerl Christopher 
Published: September 2023

AbstractInfant feeding behaviors are modulated via sensorimotor feedback, such that sensory perturbations can significantly impact performance. Properties of the nipple and milk (e.g., nipple hole size and viscosity) are critical sources of sensory information. However, the direct effects of varying milk and nipple properties on infant motor output and the subsequent changes in feeding performance are poorly understood. In this study, we use an infant pig model to explore the interaction between nipple hole size and milk viscosity. Using high‐speed videofluoroscopy and electromyography, we measured key performance metrics including sucks per swallow and suck duration, then synchronized these data with the onset and offset of activity of jaw opening and closing muscles. The combination of a small nipple hole and thick milk resulted in negative effects on both suck and swallow performance, with reduced feeding efficiency compared to the other treatments. It also appears that this combination of viscosity and hole size disrupts the coordination between correlates of tongue and jaw movements. We did not see a difference in feeding efficiency between viscosities when infants fed on the large‐hole nipple, which may be the result of non‐Newtonian fluid mechanics. Our results emphasize the importance of considering both fluid and nipple properties when considering alterations to an infant's feeding system.
Human in vivo evidence of reduced astrocyte activation and neuroinflammation in patients with treatment‐resistant depression following electroconvulsive therapy
Authors: Xu Shu‐xian , Xie Xin‐hui , Yao Lihua , Wang Wei , Zhang Honghan , Chen Mian‐mian , Sun Siqi , Nie Zhao‐wen , Nagy Corina , Liu Zhongchun 
Published: September 2023

AimThe current study aimed to investigate the neuroinflammatory hypothesis of depression and the potential anti‐inflammatory effect of electroconvulsive therapy (ECT) in vivo, utilizing astrocyte‐derived extracellular vesicles (ADEVs) isolated from plasma.MethodsA total of 40 patients with treatment‐resistant depression (TRD) and 35 matched healthy controls were recruited at baseline, and 34 patients with TRD completed the post‐ECT visits. Blood samples were collected at baseline and post‐ECT. Plasma ADEVs were isolated and confirmed, and the concentrations of two astrocyte markers (glial fibrillary acidic protein [GFAP] and S100β), an extracellular vesicle marker cluster of differentiation 81 (CD81), and nine inflammatory markers in ADEVs were measured as main analyses. In addition, correlation analysis was conducted between clinical features and ADEV protein levels as exploratory analysis.ResultsAt baseline, the TRD group exhibited significantly higher levels of two astrocyte markers GFAP and S100β, as well as CD81 compared with the healthy controls. Inflammatory markers interferon γ (IFN‐γ), interleukin (IL) 1β, IL‐4, IL‐6, tumor necrosis factor α, IL‐10, and IL‐17A were also significantly higher in the TRD group. After ECT, there was a significant reduction in the levels of GFAP, S100β, and CD81, along with a significant decrease in the levels of IFN‐γ and IL‐4. Furthermore, higher levels of GFAP, S100β, CD81, and inflammatory cytokines were associated with more severe depressive symptoms and poorer cognitive function.ConclusionThis study provides direct insight supporting the astrocyte activation and neuroinflammatory hypothesis of depression using ADEVs. ECT may exert an anti‐inflammatory effect through inhibition of such activation of astrocytes.