bluuebunny/crossref_metadata_2025_split huggingface dataset:
CircFNDC3B regulates osteoarthritis and oxidative stress by targeting miR-525-5p/HO-1 axis
Authors: Chen Zizheng , Huang Yizhen , Chen Yu , Yang Xiaodong , Zhu Jinjin , Xu Guang , Shen Shuying , Hu Ziang , Shi Peihua , Ma Yan , Fan Shunwu 
Published: February 2023

AbstractOsteoarthritis (OA) is a common chronic degenerative joint disease associated with a variety of risk factors including aging, genetics, obesity, and mechanical disturbance. This study aimed to elucidate the function of a newly discovered circular RNA (circRNA), circFNDC3B, in OA progression and its relationship with the NF-κB signaling pathway and oxidative stress. The circFNDC3B/miR-525-5p/HO-1 axis and its relationship with the NF-κB signaling pathway and oxidative stress were investigated and validated using fluorescence in situ hybridization, real-time PCR, western blotting, immunofluorescence analysis, luciferase reporter assays, pull-down assays, and reactive oxygen species analyses. The functions of circFNDC3B in OA was investigated in vitro and in vivo. These evaluations demonstrated that circFNDC3B promotes chondrocyte proliferation and protects the extracellular matrix (ECM) from degradation. We also revealed that circFNDC3B defends against oxidative stress in OA by regulating the circFNDC3B/miR-525-5p/HO-1 axis and the NF-κB signaling pathway. Further, we found that overexpression of circFNDC3B alleviated OA in a rabbit model. In summary, we identified a new circFNDC3B/miR-525-5p/HO-1 signaling pathway that may act to relieve OA by alleviating oxidative stress and regulating the NF-κB pathway, resulting in the protection of the ECM in human chondrocytes, highlighting it as a potential therapeutic target for the treatment of OA.
Momentum-resolved electronic structure of LaTiO2N photocatalysts by resonant Soft-X-ray ARPES
Authors: Lawley Craig , Arab Arian , Hartl Anna , Staykov Aleksandar , Döbeli Max , Schmitt Thorsten , Pergolesi Daniele , Lippert Thomas , Strocov Vladimir N. 
Published: February 2023

AbstractOxynitrides are promising materials for visible light-driven water splitting. However, limited information regarding their electron-momentum resolved electronic structure exists. Here, with the advantage of the enhanced probing depth and chemical state specificity of soft-X-ray ARPES, we determine the electronic structure of the photocatalyst oxynitride LaTiO2N and monitor its evolution as a consequence of the oxygen evolution reaction. After the photoelectrochemical reactions, we observe a partial loss of Ti- and La-N 2p states, distortions surrounding the local environment of titanium atoms and, unexpectedly, an indication of an electron accumulation layer at or near the surface, which may be connected with either a large density of metallic surface states or downward band bending. The distortions and defects associated with the titanium 3d states lead to the trapping of electrons and charge recombination, which is a major limitation for the oxynitride LaTiO2N. The presence of an accumulation layer and its evolution suggests complex mechanisms of the photoelectrochemical reaction, especially in cases where co-catalysts or passivation layers are used.
Forecasting hospital-level COVID-19 admissions using real-time mobility data
Authors: Klein Brennan , Zenteno Ana C. , Joseph Daisha , Zahedi Mohammadmehdi , Hu Michael , Copenhaver Martin S. , Kraemer Moritz U. G. , Chinazzi Matteo , Klompas Michael , Vespignani Alessandro , Scarpino Samuel V. , Salmasian Hojjat 
Published: February 2023

Abstract
Background
For each of the COVID-19 pandemic waves, hospitals have had to plan for deploying surge capacity and resources to manage large but transient increases in COVID-19 admissions. While a lot of effort has gone into predicting regional trends in COVID-19 cases and hospitalizations, there are far fewer successful tools for creating accurate hospital-level forecasts.

Methods
Large-scale, anonymized mobile phone data has been shown to correlate with regional case counts during the first two waves of the pandemic (spring 2020, and fall/winter 2021). Building off this success, we developed a multi-step, recursive forecasting model to predict individual hospital admissions; this model incorporates the following data: (i) hospital-level COVID-19 admissions, (ii) statewide test positivity data, and (iii) aggregate measures of large-scale human mobility, contact patterns, and commuting volume.

Results
Incorporating large-scale, aggregate mobility data as exogenous variables in prediction models allows us to make hospital-specific COVID-19 admission forecasts 21 days ahead. We show this through highly accurate predictions of hospital admissions for five hospitals in Massachusetts during the first year of the COVID-19 pandemic.

Conclusions
The high predictive capability of the model was achieved by combining anonymized, aggregated mobile device data about users’ contact patterns, commuting volume, and mobility range with COVID hospitalizations and test-positivity data. Mobility-informed forecasting models can increase the lead-time of accurate predictions for individual hospitals, giving managers valuable time to strategize how best to allocate resources to manage forthcoming surges.
Noise Exposure in Palestinian Workers Without a Diagnosis of Hearing Impairment: Relations to Speech-Perception-in-Noise Difficulties, Tinnitus, and Hyperacusis
Authors: Shehabi Adnan M. , Prendergast Garreth , Guest Hannah , Plack Christopher J. 
Published: February 2023

Purpose:
Many workers in developing countries are exposed to unsafe occupational noise due to inadequate health and safety practices. We tested the hypotheses that occupational noise exposure and aging affect speech-perception-in-noise (SPiN) thresholds, self-reported hearing ability, tinnitus presence, and hyperacusis severity among Palestinian workers.

Method:

Palestinian workers (
N
= 251, aged 18–70 years) without diagnosed hearing or memory impairments completed online instruments including a noise exposure questionnaire; forward and backward digit span tests; hyperacusis questionnaire; the short-form Speech, Spatial and Qualities of Hearing Scale (SSQ12); the Tinnitus Handicap Inventory; and a digits-in-noise (DIN) test. Hypotheses were tested via multiple linear and logistic regression models, including age and occupational noise exposure as predictors, and with sex, recreational noise exposure, cognitive ability, and academic attainment as covariates. Familywise error rate was controlled across all 16 comparisons using the Bonferroni–Holm method. Exploratory analyses evaluated effects on tinnitus handicap. A comprehensive study protocol was preregistered.

Results:
Nonsignificant trends of poorer SPiN performance, poorer self-reported hearing ability, greater prevalence of tinnitus, greater tinnitus handicap, and greater severity of hyperacusis as a function of higher occupational noise exposure were observed. Greater hyperacusis severity was significantly predicted by higher occupational noise exposure. Aging was significantly associated with higher DIN thresholds and lower SSQ12 scores, but not with tinnitus presence, tinnitus handicap, or hyperacusis severity.

Conclusions:
Workers in Palestine may suffer from auditory effects of occupational noise and aging despite no formal diagnosis. These findings highlight the importance of occupational noise monitoring and hearing-related health and safety practices in developing countries.

Supplemental Material:

https://doi.org/10.23641/asha.22056701
Optimal feature‐algorithm combination research for EEG fatigue driving detection based on functional brain network
Authors: Zhou Yi , Zeng ChangQing , Mu ZhenDong 
Published: February 2023

AbstractWith the increasing number of motor vehicles globally, the casualties and property losses caused by traffic accidents are substantial worldwide. Traffic accidents caused by fatigue driving are also increasing year by year. In this article, the authors propose a functional brain network‐based driving fatigue detection method and seek to combine features and algorithms with optimal effect. First, a simulated driving experiment is established to obtain EEG signal data from multiple subjects in a long‐term monotonic cognitive task. Second, the correlation between each EEG signal channel is calculated using Pearson correlation coefficient to construct a functional brain network. Then, five functional brain network features (clustering coefficient, node degree, eccentricity, local efficiency, and characteristic path length) are extracted and combined to obtain a total of 26 features and eight machine learning algorithms (SVM, LR, DT, RF, KNN, LDA, ADB, GBM) are used as classifiers for fatigue detection respectively. Finally, the optimal combination of features and algorithms are obtained. The results show that the feature combination of node degree, local efficiency, and characteristic path length achieves the best classification accuracy of 92.92% in the logistic regression algorithm.
Performance analysis and control of a novel 7‐level active neutral point clamped (ANPC) topology
Authors: Zaid Mohammad , Sarwar Adil , Quayyoom Layeba , Tayyab Mohammad , Bakhsh Farhad Ilahi , Iqbal Atif , Ahmad Akbar 
Published: February 2023

AbstractThis paper introduces a novel 7‐level active neutral‐point clamped (ANPC) switched capacitor multilevel inverter (SCMLI) with voltage‐boosting capabilities. The proposed converter can produce seven levels and a voltage boosting of 1.5 times with a single dc source. For boosting the voltage, two self‐balanced switched capacitors and two dc link capacitors with active neutral point are used with nine switches. For controlling the output voltage, the level‐shifted modulation technique and modified nearest level control technique is used. The performance of the converter is evaluated with both modulation techniques. The operation of the proposed SCMLI and the design of capacitors for the proposed circuit is discussed in detail. The proposed topology can eliminate the leakage current and has reduced voltage stress across switches which makes it suitable for solar photovoltaic applications. The proposed converter is compared with some other recently introduced converters in terms of voltage gain, the number of components used, and the voltage stress across the switches. For verifying the performance of the proposed circuit, the experimental and simulation results are presented in the paper. The experimental results closely agree with the simulation and theoretical studies. The total harmonic distortion (THD) in the output voltage and efficiency is compared with both modulation techniques.
Continuum reverberation mapping of MCG 08-11-011
Authors: Fian C. , Chelouche D. , Kaspi S. , Sobrino Figaredo C. , Lewis T. , Catalan S. 
Published: February 2023

Aims. We report the results from a photometric reverberation mapping campaign carried out with the C18 telescope at the Wise Observatory from 2019 to 2020, targeting the active galactic nucleus (AGN) MCG 08-11-011. The monitoring was conducted on a daily basis with specially designed narrow-band filters, spanning from optical to near-infrared wavelengths (∼4000 to 8000 Å) and avoiding prominent broad emission lines. We aim to measure inter-band continuum time lags, determine the size–wavelength relation, and estimate the host-subtracted AGN luminosity for this system.
Methods. We used the point-spread function photometry to extract the continuum light curves and measure the inter-band time lags using several methods, including the interpolated cross-correlation function, the z-transformed discrete correlation function, a von Neumann estimator, JAVELIN (in spectroscopic and photometric mode), MICA, and a multivariate correlation function.
Results. We find wavelength-dependent lags, τ(λ), up to ∼7 days between the multiband light curves of MCG 08-11-011. The observed lags are larger than predictions based on standard thin-disk theory by a factor of ∼3 − 7. We discern a significantly steeper (τ ∝ λ4.74) size-wavelength relation than the τ ∝ λ4/3 expected for a geometrically thin and optically thick accretion disk, which may result from the contribution of diffuse continuum emission to the flux. These results are similar to those found by previous continuum reverberation mapping campaigns.
Direct imaging discovery of a super-Jovian around the young Sun-like star AF Leporis
Authors: De Rosa Robert J. , Nielsen Eric L. , Wahhaj Zahed , Ruffio Jean-Baptiste , Kalas Paul G. , Peck Anne E. , Hirsch Lea A. , Roberson William 
Published: February 2023

Context.Expanding the sample of directly imaged companions to nearby, young stars that are amenable to detailed astrometric and spectroscopic studies is critical for the continued development and validation of theories of their evolution and atmospheric processes.Aims.The recent release of theGaiaastrometric catalog allows us to efficiently search for these elusive companions by targeting those stars that exhibit the astrometric reflex motion induced by an orbiting companion. The nearby (27 pc), young (24 Myr) star AF Leporis (AF Lep) was targeted because of its significant astrometric acceleration measured between the HIPPARCOSandGaiaastrometric catalogs, consistent with a wide-orbit planetary-mass companion detectable with high-contrast imaging.Methods.We used the SPHERE instrument on the VLT to search for faint substellar companions in the immediate vicinity of AF Lep. We used observations of a nearby star interleaved with those of AF Lep to efficiently subtract the residual point spread function. This provided sensitivity to faint planetary-mass companions within 1″ (~30 au) of the star.Results.We detected the companion AF Lep b at a separation of 339 mas (9 au) from the host star, at almost the exact location predicted by the astrometric acceleration, and within the inner edge of its unresolved debris disk. The measured K-band contrast and the age of the star yield a model-dependent mass of between 4 and 6MJup, consistent with the mass derived from an orbital fit to the absolute and relative astrometry of 4.3−1.2+2.9MJup. The near-infrared spectral energy distribution of the planet is consistent with an object at the L−T spectral type transition, but under-luminous with respect to field-gravity objects.Conclusions.AF Lep b joins a growing number of substellar companions imaged around stars in the youngβPictoris moving group. With a mass of between 3 and 7MJup, it occupies a gap in this isochronal sequence between hotter, more massive companions, such as PZ Tel B andβPic b, and the cooler 51 Eri b, which is sufficiently cool for methane to form within its photosphere. Lying at the transition between these two classes of objects, AF Lep b will undoubtedly become a benchmark for studies of atmospheric composition and processes, as well as an anchor for models of the formation and evolution of substellar and planetary-mass companions.
La possibilité d’un paysage chez l’agoraphobe
Authors: Fourment-Aptekman Marie-Claude 
Published: February 2023

La construction d’un paysage est-elle compatible avec l’agoraphobie ? Cette question sera analysée à partir de la description de cas cliniques variés, puis par un retour sur les définitions multiples du paysage. C’est à partir de ces considérations que nous émettrons l’hypothèse que la construction d’un paysage est possible chez tout être humain, même agoraphobe, si certaines conditions paysagères sont réunies, et aussi, grâce au travail de mémoire, à la littérature, à la peinture, au cinéma, et aux différents arts qui nous permettent d’avoir nos paysages à la fois comme espace intérieur et comme ouverture sur le monde.
Chronobiologische Schlafforschung
Authors: Zulley Jürgen 
Published: February 2023

ZusammenfassungBiologische Rhythmen über 24 Stunden betreffen praktisch alle Funktionen lebender Organismen. Diese Rhythmen sind nicht nur Folge des Tag-Nacht- oder Schlaf-Wach-Wechsels, sondern sie werden auch von „inneren Uhren“ erzeugt, sind mithin Ausdruck eines endogenen biologischen Rhythmus. Die im Beitrag beschriebenen Schlafstudien im Andechser Bunker weisen auf eine robuste Interaktion zwischen den biologischen Rhythmen und der Schlafregulation hin. Der zirkadiane Rhythmus (subjektiver und biologischer Tag) beträgt im Freilauf 25 Stunden. In unserem Alltag unter Einfluss des Tag-Nacht-Wechsels wird auch er vor allem durch den Einfluss des Tageslichts auf 24 Stunden synchronisiert. Helles Licht ist der wichtigste Zeitgeber, den die Menschen benötigen, um ihre biologischen Rhythmen „im Takt“ zu halten. Die biologischen Rhythmen geben bevorzugte Zeiträume für das Schlafen und das Wachen vor: Gegen 3 Uhr nachts findet sich ein biologisches Tief für viele Funktionen, gegen 17 Uhr herrscht verminderter Schlafdruck. Der Mittagsschlaf hat eine biologische Basis. Nächtliches kurzes Erwachen ist normal, gegen 3 Uhr sogar längeres Wachsein. Die spontane Schlafdauer beträgt 7–8 Stunden, sie setzt sich aber aus 2 kürzeren Schlafblöcken zusammen. Vor allem die Qualität des Tiefschlafs ist für den Erholungswert des Schlafes verantwortlich. Sein Auftreten hängt von der Dauer der vorhergehenden Wachzeit ab und ist unabhängig von der Schlafdauer.
Vaskulitis mimics
Authors: Schirmer Jan Henrik , Both Marcus , Müller OliverJ 
Published: February 2023

ZusammenfassungIdiopathische Vaskulitiden sind seltene entzündliche Systemerkrankungen,
die nach der Chapel-Hill Konsensus-Nomenklatur nach der Größe
der prädominant betroffenen Gebiete von Blutgefäßen
(große, mittelgroße, kleine Gefäße und
Gefäße variabler Größe) eingeteilt werden.
Vaskulitis mimics sind Syndrome, die ein ähnliches klinisches Bild
hervorrufen oder leicht mit einer idiopathischen Vaskulitis verwechselt werden
und teils sogar ein Krankheitsbild, das klinisch und histologisch einer
Vaskulitis gleicht, auslösen können. Die Zahl der Vaskulitis
mimics ist groß, je nach betroffenem Gefäßgebiet kommen
hereditäre Erkrankungen des Bindegewebes, genetisch bedingte
Immundefekt- und Autoinflammationssyndrome, infektiöse Erkrankungen,
seltene entzündliche Systemerkrankungen, Tumorerkrankungen,
medikamenteninduzierte Syndrome und zahlreiche weitere infrage. In diesem Review
wird eine Auswahl klassischer Imitatoren von Vaskulitiden, orientiert an der
Größe der betroffenen Blutgefäße
präsentiert und Konstellationen, die typische
„Fallstricke“ in der klinischen Abklärung darstellen
können, diskutiert.
A Review of FXIa Inhibition as a Novel Target for Anticoagulation
Authors: Koulas Ioannis , Spyropoulos Alex C. 
Published: February 2023

AbstractLimitations of vitamin K antagonists as chronic oral anticoagulant therapy have largely been supplanted by direct factor IIa and factor Xa inhibitor oral anticoagulants with similar efficacy but an overall better safety profile, lack of routine monitoring, and very limited drug–drug interactions compared with agents such as warfarin. However, an increased risk of bleeding remains even with these new-generation oral anticoagulants in fragile patient populations, in patients requiring dual or triple antithrombotic therapy, or high bleed risk surgeries. Epidemiologic data in patients with hereditary factor XI deficiency and preclinical studies support the notion that factor XIa inhibitors have the ability to be an effective but potentially safer alternative to existing anticoagulants, based on their ability to prevent thrombosis directly within the intrinsic pathway without affecting hemostatic mechanisms. As such, various types of factor XIa inhibitors have been studied in early phase clinical studies, including inhibitors of the biosynthesis of factor XIa with antisense oligonucleotides or direct inhibitors of factor XIa using small peptidomimetic molecules, monoclonal antibodies, aptamers, or natural inhibitors. In this review, we discuss how different types of factor XIa inhibitors work and present findings from recently published Phase II clinical trials across multiple indications, including stroke prevention in atrial fibrillation, dual pathway inhibition with concurrent antiplatelets post–myocardial infarction, and thromboprophylaxis of orthopaedic surgery patients. Finally, we refer to ongoing Phase III clinical trials of factor XIa inhibitors and their potential to provide definitive answers regarding their safety and efficacy in preventing thromboembolic events in specific patient groups.
Diagnostic Performance of a Particle Gel Immunoassay in Vaccine-Induced Immune Thrombotic Thrombocytopenia
Authors: Uzun Günalp , Althaus Karina , Hammer Stefanie , Wanner Yvonne , Nowak-Harnau Stefanie , Enkel Sigrid , Bakchoul Tamam 
Published: February 2023

AbstractVaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but serious complication of adenoviral vector-based COVID-19 vaccines. Similar to heparin-induced thrombocytopenia (HIT), antibodies reacting to platelet factor 4 (PF4) are responsible for platelet activation in VITT. The diagnosis of VITT includes the detection of anti-PF4 antibodies. Particle gel immunoassay (PaGIA) is one of the rapid immunoassays that is commonly used in the diagnosis of HIT to detect anti-PF4 antibodies. The aim of this study was to investigate the diagnostic performance of PaGIA in patients suspected of VITT. In this retrospective, single-center study, the correlation between PaGIA, enzyme immunoassay (EIA), and modified heparin-induced platelet aggregation assay (HIPA) in patients with findings suggestive of VITT was investigated. A commercially available PF4 rapid immunoassay (ID PaGIA H/PF4, Bio-Rad-DiaMed GmbH, Switzerland) and an anti-PF4/heparin EIA (ZYMUTEST HIA IgG, Hyphen Biomed) were used according to manufacturer's instructions. Modified HIPA was accepted as the gold standard test. Between March 8 and November 19, 2021, a total of 34 samples from clinically well-characterized patients (14 males, 20 females, mean age: 48.2 ± 18.2 years) were analyzed with PaGIA, EIA, and modified HIPA. VITT was diagnosed in 15 patients. Sensitivity and specificity of PaGIA were 54 and 67%, respectively. Anti-PF4/heparin optical density values were not significantly different between PaGIA positive and negative samples (p = 0.586). The sensitivity and specificity of EIA, on the other hand, were 87 and 100%, respectively. In conclusion, PaGIA is not reliable in the diagnosis of VITT because of its low sensitivity and specificity.
Inherited Platelet Disorders: A Short Introduction
Authors: Zieger Barbara , Boeckelmann Doris 
Published: February 2023

AbstractPlatelets play an important role regarding coagulation by contributing to thrombus formation by platelet adhesion, aggregation, and α-/δ-granule secretion. Inherited platelet disorders (IPDs) are a very heterogeneous group of disorders that are phenotypically and biochemically diverse. Platelet dysfunction (thrombocytopathy) can be accompanied by a reduction in the number of thrombocytes (thrombocytopenia). The extent of the bleeding tendency can vary greatly. Symptoms comprise mucocutaneous bleeding (petechiae, gastrointestinal bleeding and/or menorrhagia, epistaxis) and increased hematoma tendency. Life-threatening bleeding can occur after trauma or surgery. In the last years, next-generation sequencing had a great impact on unrevealing the underlying genetic cause of individual IPDs. Because IPDs are so diverse, a comprehensive analysis of platelet function and genetic testing is indispensable.