bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring longitudinal changes in implicit awareness of dementia: An investigation of the emotional Stroop effect in healthy ageing and mild dementia
Authors: Martyr Anthony , Nelis Sharon M. , Morris Robin G. , Marková Ivana S. , Roth Ilona , Woods Robert T. , Clare Linda 
Published: September 2023

AbstractThe aim of the study was to investigate responses to dementia‐relevant words in healthy older people and to investigate changes in response over 20‐months in people with early‐stage dementia. An emotional Stroop task, using colour‐naming dementia‐relevant words, was used as an indicator of implicit awareness of dementia. Overall, 24 people with dementia and 24 healthy older people completed an emotional Stroop task (T1). People with dementia completed the same task again after 12 (T2) and 20 (T3) months. For people with dementia emotional Stroop performance was contrasted with ratings of explicit awareness based on a detailed interview at T1 and at T2. For healthy older people and people with dementia response times to dementia‐relevant words were significantly longer than those for neutral words. The effect was absent for people with dementia at T3. This decline in the emotional Stroop effect was not associated with cognitive decline as measured by the MMSE. Ratings of explicit awareness showed no significant change over time. There was no association between explicit awareness and implicit awareness. Implicit awareness of the condition is evident in early‐stage dementia and can be elicited even where there is reduced explicit awareness. The emotional Stroop effect for dementia‐relevant words in people with dementia appears to decline over time, independently of changes in MMSE score, suggesting that implicit awareness fades as time progresses.
Paclitaxel‐carboplatin plus bevacizumab therapy for advanced neuroendocrine carcinoma of the uterine cervix: A retrospective case series
Authors: Kotaka Saki , Kondo Eiji , Kawai Yosuke , Okamoto Kota , Kishigami Yasuyuki , Yamawaki Takaharu , Nagao Kenji , Toru Hirata , Suzuki Shiro 
Published: September 2023

AbstractAimThere is no conclusive data on the prognosis of patients who receive paclitaxel‐carboplatin (TC) plus bevacizumab therapy for advanced neuroendocrine carcinoma (NEC) of the uterine cervix, a rare histological subtype of cervical cancer. Thus, the aim of this study was to determine the efficacy of TC chemotherapy plus bevacizumab and bevacizumab single maintenance therapy for advanced NEC of the cervix.MethodsThis was a retrospective review of patients who received TC plus bevacizumab therapy for metastatic, recurrent, or persistent NEC of the cervix at seven institutions between 2015 and 2020. Relevant data were extracted from the patients' medical records and analyzed.ResultsSeven patients, including six with small‐cell NEC and one with large‐cell NEC, were included for analysis. Three patients received bevacizumab single maintenance therapy following TC plus bevacizumab therapy, whereas four patients did not receive bevacizumab single maintenance therapy. The median overall survival and progression‐free survival of the patients who received bevacizumab single maintenance therapy were longer than those of the patients who did not receive the therapy (34 months vs. 10.5 months and 19 months vs. 5 months, respectively). However, the patients who received bevacizumab single maintenance therapy had received cisplatin‐based chemotherapy previously.ConclusionsOn the premise that cisplatin‐based chemotherapy is administered as the first‐line treatment for advanced NEC of the cervix, bevacizumab single maintenance therapy following TC plus bevacizumab may be considered the second‐ or third‐line treatment. However, the risk of adverse events, such as intestinal perforation, should be discussed with patients.
Laparoscopic versus open radical hysterectomy in FIGO 2018 early‐stage cervical adenocarcinoma: Long‐term survival outcomes after propensity score matching
Authors: Yin Zhaohong , Cui Zhumei , Kang Shan , Ji Mei , Li Donglin , Chen Biliang , Zhan Xuemei , Li Weili , Liu Ping , Chen Chunlin 
Published: September 2023

AbstractObjectiveTo compare the long‐term survival outcomes of laparoscopic radical hysterectomy (LRH) and open radical hysterectomy (ORH) in International Federation of Gynecology and Obstetrics (FIGO) 2018 early‐stage cervical adenocarcinoma.MethodsBased on the clinical diagnosis and treatment for cervical cancer in mainland China (Four C) database, the medical records of 1098 patients with FIGO 2018 early‐stage cervical adenocarcinoma were retrospectively reviewed. Long‐term and short‐term survival outcomes of the two groups were compared using a multivariate Cox regression model and the log‐rank method in the whole study population and after propensity score matching.ResultsThere was no difference in disease‐free survival (hazard ratio [HR] 0.921, 95% confidence interval [CI]: 0.532–1.595, p = 0.770) and overall survival (HR 1.168, 95% CI: 0.526–2.592, p = 0.702) between LRH (n = 468) and ORH (n = 468) in the risk‐adjusted analysis. LRH resulted in significantly lower estimated blood loss (342.7 vs. 157.5 mL, p < 0.001) and shorter postoperative anal exhaust time (2.8 vs. 2.5 days, p < 0.001) in risk‐adjusted analysis. The overall rates of intraoperative complications (2.4% vs. 4.3%, p = 0.100) and postoperative complications (7.5% vs. 6.2%, p = 0.437) showed no significant difference between the two groups. However, the LRH group had a significantly higher incidence of ureter injury (0.4% vs. 2.4%, p = 0.012) and great vessel injury (0.0% vs. 0.9%, p = 0.045) compared to the other group. No statistical variation in the site of recurrence was observed between the two groups (p = 0.613).ConclusionsLRH has comparable survival outcomes with ORH and was associated with earlier recovery in FIGO 2018 early‐stage adenocarcinoma of the uterine cervix. However, the LRH group had higher risk of ureter injury and great vessel injury.
A technique to convert a 3D printed cast used in the fabrication of an interim implant‐supported crown into a definitive cast capturing the acquired emergence profile
Authors: Mohsen Rawan , Chen Yu‐Jen , Liu Fei 
Published: September 2023

AbstractAn esthetic peri‐implant soft tissue contour is a critical element of the success of implant restorations in the esthetic zone. Once the optimal transmucosal soft tissue profile is formed, it needs to be accurately replicated on the master cast. This clinical technique involves the utilization of a silicone putty positioning index placed in the patient's mouth to accurately duplicate the external contour of teeth and soft tissue. By combining this positioning index with the implant‐supported interim crown, the 3D‐printed initial cast, which was used to fabricate the interim crown, can be conveniently and efficiently transformed into a definitive master cast.
The Effects of Internal Focus of Attention and Interoceptive Abilities on Golf Putting Performance
Authors: Mizuno Kanta , Masaki Hiroaki 
Published: September 2023

AbstractAn internal focus on movement interferes with automated movement execution, but physical sensations may not diminish performance. We hypothesized that interoception—a perception of the inner workings of the body—is associated with maintaining performance under internal focus. Eighteen competitive swimmers with high interoceptive ability and nine controls with no sports experience executed a golf putting task under pressure and no‐pressure tests, while the direction of attentional focus was manipulated. We recorded electroencephalograms and electrocardiograms during the task in three attentional conditions (i.e., sensation‐focus, movement‐focus, and no‐focus instruction). Interoceptive accuracy was evaluated by a heartbeat counting task and interoceptive sensibility was obtained using the Multidimensional Assessment of Interoceptive Awareness questionnaire. Results showed that internal focus on movement led to lower performance compared to the no‐focus instruction in both groups, whereas focusing on physical sensations did not change performance. Higher interoceptive sensibility predicted better performance when focusing on movement. These results suggest that higher interoceptive ability may prevent performance deterioration due to an internal focus toward movement.
Developing model systems for dinoflagellates in the post‐genomic era
Authors: Ishida Hisatake , John Uwe , Murray Shauna A. , Bhattacharya Debashish , Chan Cheong Xin 
Published: September 2023

AbstractDinoflagellates are a diverse group of eukaryotic microbes that are ubiquitous in aquatic environments. Largely photosynthetic, they encompass symbiotic, parasitic, and free‐living lineages with a broad spectrum of trophism. Many free‐living taxa can produce bioactive secondary metabolites such as biotoxins, some of which cause harmful algal blooms. In contrast, most symbiotic species are crucial for sustaining coral reef health. The year 2023 marked a decade since the first genome data of dinoflagellates became available. The growing genome‐scale resources for these taxa are highlighting their remarkable evolutionary and genomic complexities. Here, we discuss the prospect of developing dinoflagellate models using the criteria of accessibility, tractability, resources, research support, and promise. Moving forward in the post‐genomic era, we argue for the development of fit‐to‐purpose models that tailor to specific biological contexts, and that a one‐size‐fits‐all model is inadequate for encapsulating the complex biology, ecology, and evolutionary history of dinoflagellates.
Chlormethiazole as a hypnotic in elderly patients: A systematic review and meta‐analysis
Authors: Al Juburi Marwa , Cramer Holger , Schaefer Martin 
Published: September 2023

SummaryThe study objective was to estimate the efficacy and safety of chlormethiazole in older adults experiencing insomnia (sleep disorder). We therefore systematically searched Medline, Scopus, the Cochrane Library, PsycINFO, Ovid, ZB MED and PMC through December 2021 for randomized–controlled trials including patients > 60 years old with insomnia treated with chlormethiazole. Standardized mean differences or odds ratios with 95% confidence intervals were calculated for the main outcome parameters: sleep duration, onset of sleep, quality of sleep, adverse events or drop‐out rates compared with placebo and other drugs. Risk of bias was assessed using the Cochrane tool. Eight randomized–controlled trials with 424 patients were included. Chlormethiazole significantly increased the duration of sleep when compared with placebo (standardized mean difference = 0.61; 95% confidence interval = 0.11–1.11; p = 0.02). More patients receiving chlormethiazole had adequate quality of sleep than those receiving other drugs (odds ratio = 1.44; 95% confidence interval = 1.04–1.98; p = 0.03). No differences were found regarding the onset of sleep (standardized mean difference = 1.07; 95% confidence interval = 0.79–1.46; p = 0.65). Drop‐out rates were significantly lower under chlormethiazole treatment when compared with other drugs (odds ratio = 0.51; 95% confidence interval = 0.26–0.99; p = 0.05) and did not differ from placebo treatment (odds ratio = 1.37; 95% confidence interval = 0.23–8.21; p = 0.73). Side‐effects such as “hangover” and daytime drowsiness occurred less frequently during chlormethiazole treatment compared with other drugs in three out of four studies, but differences were not significant (odds ratio = 0.24; 95% confidence interval = 0.04–1.48; p = 0.12). In conclusion, chlormethiazole showed significant effects on the duration and the quality of sleep with better tolerability if compared with other drugs in older adults with insomnia.
Dietary nucleotides can prevent glucocorticoid‐induced telomere attrition in a fast‐growing wild vertebrate
Authors: Casagrande Stefania , Loveland Jasmine L. , Oefele Marlene , Boner Winnie , Lupi Sara , Stier Antoine , Hau Michaela 
Published: September 2023

AbstractTelomeres are chromosome protectors that shorten during eukaryotic cell replication and in stressful conditions. Developing individuals are susceptible to telomere erosion when their growth is fast and resources are limited. This is critical because the rate of telomere attrition in early life is linked to health and life span of adults. The metabolic telomere attrition hypothesis (MeTA) suggests that telomere dynamics can respond to biochemical signals conveying information about the organism's energetic state. Among these signals are glucocorticoids, hormones that promote catabolic processes, potentially impairing costly telomere maintenance, and nucleotides, which activate anabolic pathways through the cellular enzyme target of rapamycin (TOR), thus preventing telomere attrition. During the energetically demanding growth phase, the regulation of telomeres in response to two contrasting signals – one promoting telomere maintenance and the other attrition – provides an ideal experimental setting to test the MeTA. We studied nestlings of a rapidly developing free‐living passerine, the great tit (Parus major), that either received glucocorticoids (Cort‐chicks), nucleotides (Nuc‐chicks) or a combination of both (NucCort‐chicks), comparing these with controls (Cnt‐chicks). As expected, Cort‐chicks showed telomere attrition, while NucCort‐ and Nuc‐chicks did not. NucCort‐chicks was the only group showing increased expression of a proxy for TOR activation (the gene TELO2), of mitochondrial enzymes linked to ATP production (cytochrome oxidase and ATP‐synthase) and a higher efficiency in aerobically producing ATP. NucCort‐chicks had also a higher expression of telomere maintenance genes (shelterin protein TERF2 and telomerase TERT) and of enzymatic antioxidant genes (glutathione peroxidase and superoxide dismutase). The findings show that nucleotide availability is crucial for preventing telomere erosion during fast growth in stressful environments.
Clostridium butyricum MIYAIRI 588 alleviates periodontal bone loss in mice with diabetes mellitus
Authors: Zhang Yanan , Lu Miao , Zhang Yang , Yuan Xulei , Zhou Mengjiao , Xu Xiaohui , Zhang Tingwei , Song Jinlin 
Published: September 2023

AbstractThe gut microbiota is a bridge linking periodontitis and systemic diseases, such as diabetes mellitus (DM). The probiotic Clostridium butyricum MIYAIRI 588 (CBM588) is reportedly an effective therapeutic approach for gut dysbiosis. Here, in a mouse model, we explored the therapeutic effect of CBM588 on periodontal bone destruction in DM and DM‐associated periodontitis (DMP), as well as the underlying mechanism. Micro‐computed tomography revealed that DM and DMP both aggravated periodontal bone destruction, which was alleviated by intragastric supplementation with CBM588. Moreover, 16S rRNA sequencing and untargeted metabolite analysis indicated that CBM588 ameliorated DMP‐triggered dysbiosis and led to reduced oxidative stress associated with elevated 4‐hydroxybenzenemethanol (4‐HBA) in serum. Furthermore, in vitro and in vivo experiments found that the metabolite 4‐HBA promoted nuclear factor erythroid 2‐related factor 2 (Nrf2) signaling activation and modulated the polarization of macrophages, thus ameliorating inflammatory bone destruction in DMP. Our study demonstrates the protective effects of CBM588 in DM‐induced mice, with and without ligature‐induced periodontitis. The mechanism involves regulation of the gut microbiota and restoration of the integrity of the gut barrier to alleviate oxidative damage by elevating serum 4‐HBA. This study suggests the possibility of CBM588 as a therapeutic adjuvant for periodontal treatment in diabetes patients.
The madness of unrestrained reason: Reason and madness in Molière's Le misanthrope
Authors: Boysen Benjamin 
Published: September 2023

AbstractIn Molière's celebrated Le misanthrope, the spectator is witness to an immensely funny, albeit profound staging of the limits of rationality. The comedy exhibits how an idealist idea of the pure sovereignty of reason is ridiculous, self‐contradictory, and mad, since the distinction between ideality and reality, the universal and the particular, the social and the individual, is ignored or even dissolved. The comic art of literature steps forth as a joyous purging and corrective of the highly seductive, but essentially delusional appeals from philosophy and idealism to absolutize reason and thus render oneself sovereign. A totalized reason that nonetheless cancels itself and becomes madness.
The torchlight model of mapping in cognitive analytic therapy (CAT) reformulation: A qualitative investigation
Authors: Jefferis Steve , Fantarrow Zara , Johnston Lynne 
Published: September 2023

ObjectivesDespite the central role of formulation in psychological therapy, there is limited research on how formulations are constructed in clinical practice. In Cognitive Analytic Therapy (CAT), a formulation diagram (or CAT map) is used in transforming the client’s narrative into a psychological understanding of the difficulties. The objective was to build a theoretical model of the processes involved in the early stages of CAT mapping.DesignA qualitative research design using constructivist Grounded Theory Methodology (GTM) incorporating Interpersonal Process Recall (IPR) methods.MethodsCAT therapists participated in a role‐play therapy session with an actor (the 'client') and made an initial attempt at formulation by mapping. A video recording then formed the basis for a semi‐structured therapist interview. Following data analysis, a conceptual model and visual metaphor of the early process of CAT mapping was generated.ResultsThe Torchlight model conceptualizes the mapping process as a coming together of unique factors brought by client and therapist, alongside the conceptual apparatus of CAT. Each factor brings a unique light to the unfolding process of mapping and intermixes through a dialogical, collaborative process, analogous to coloured lights mixing to form new colours. The model outlines the mapping process itself as an iterative sequence of tasks, achieved through collaboration, within a growing therapeutic relationship.ConclusionsThe model offers an empirical underpinning to existing accounts of CAT mapping, and a potential tool for training.Practitioner points

The process by which individual CAT reformulation diagrams are started appears to be as unique to the therapist‐client dyad as the contents of the map, on the basis of the findings.

Mapping faithfully enacts the dialogical and developmental theoretical principles underpinning the CAT approach.

The Torchlight model is the first empirically based model of the processes taking place in the creation of CAT reformulation diagrams, in the early stages.
Experiences of receiving cognitive analytic therapy for those with complex secondary care mental health difficulties
Authors: Balmain Nadia , Melia Yvonne , John Christopher , Dent Helen , Smith Karen 
Published: September 2023

ObjectivesService users with complex mental health difficulties are more difficult to engage in treatment and drop‐out rates are higher, resulting in poorer clinical outcomes. Cognitive analytic therapy (CAT) is widely applied to service users with complex needs and shows promise in terms of engagement and outcomes. The aim of the present study was to examine the ‘lived experience’ of service users who have been retained in a full course of CAT treatment to provide important insights to why CAT seems to be an engaging psychotherapy, to inform future CAT delivery and practice with clients with complex needs.MethodSemi‐structured interviews were undertaken with six service users aged between 25 and 47 years who had accessed secondary mental health care services and had received an average of 24 sessions of CAT. Transcripts were analysed using interpretative phenomenological analysis (IPA).ResultsThe analysis yielded three superordinate themes with subthemes within these. The first superordinate theme referred to changes due to CAT (e.g., insight, tools to cope). The second theme referred to strong emotions evoked by CAT (e.g., feeling frustrated, scared, and upset). The final theme concerned the process of CAT (e.g., endings and therapeutic relationship).ConclusionsWhilst service users appeared to develop increased insight and acquire skills, there was variance in experiences of sustained and meaningful change post‐therapy. The findings suggest adaptations may be required with these service users such as delivering the sequential diagrammatic reformulation (SDR) in a hopeful way and addressing systemic barriers to ‘exits’ being made.Practitioner points

Overall, service users with complex mental health difficulties describe benefitting from CAT, identifying improved insight and the acquisition of tools to cope.

However, therapists need to be attuned to the potential fragility of service users and risk of negative affect, particularly during the reformulation phase. Consideration of delivering the SDR in a hopeful way may be therapeutic.

Systemic factors such as service users being pulled to maintain the status quo in their relationships, and lack of support for or resistance to change by important others limit service users from availing of ‘exits’ from problem procedures. This implicates the need for more attention to systemic and possibly multi‐agency working with this group of service users.
Organization‐investor fit: The role of temporal preferences in shaping investor attraction and organizational performance
Authors: Gamache Daniel L. , Busenbark John R. , Steinbach Adam L. , Lee Eric Y. , Matusik James 
Published: September 2023

AbstractFit is an essential consideration for organizations, and extensive research has explored its various types. We build on and extend fit research by advancing an important form of fit—organization‐investor (O‐I) fit, which reflects the compatibility between an organization and its investors. We argue that investors tend to be attracted to organizations whose preferences already “fit” their own and, in so doing, provide a relational perspective to the corporate governance literature that often views the relationship between investors and organizational managers as purely transactional. We focus on the fit of one of the most important factors shaping both organizational and investor behavior––temporal preferences. Specifically, we argue that investors are attracted to firms that fit with their temporal preferences and that high O‐I fit leads to better organizational performance. We tested our hypotheses in a longitudinal archival study of S&P 500 firms and supplemented these findings with two experiments. Together, we find strong support for our hypotheses. Our study showcases the critical role of O‐I fit in shaping the makeup of an organization's investors and its subsequent performance, suggesting the value for scholars, managers, and investors to consider the mutual benefits offered by fit in these relationships.