bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Dimensions of E-learning on the Successful Implementation and Development of Digital Pedagogy in Nepalese Higher-level Educational Institutions
Authors: Adhikari Basanta Pd 
Published: April 2023

The dimensions of E-learning are technology, governance, awareness of E-learning, attitude toward e-learning, and e-content development, which are supported by seventeen subfactors of the vital measurements of E-learning pedagogy. The primary objective of this study was to examine the impact of the dimensions of E-learning on the successful implementation and development factors of digital pedagogy in higher education in Nepal. The quantitative research method and the survey study were applied to collect this study's data. The results indicate a significant association between social media for E-learning, the benefits of E-learning, using E-learning applications and technology, and the effective tools for teaching and the impact of E-learning dimensions for the successful implementation and development factors of digital pedagogy (p < 0.05).
But the results indicate no association between the E-content and open educational resources, the effectiveness and challenges of E-Learning, E-contents and open educational resources, and the benefits of E-learning for students, E-learning practice, roles of E-learning in capacity building, effective E-learning methods, E-learning methodologies and good practices, sources of E-learning, and optimization of learner efficiency and productivity, and the impact of the dimensions of E-learning for the successful implementation and development of digital pedagogy ( p > 0.05). The implication of this study would be beneficial to policymakers, researchers, academicians, educators, and college leaders in such a way to provide first-hand information about the areas to be focused on for successful implementation and development factors on E-learning pedagogy in the Nepalese higher education sector.
A Review of an Article Based on the Mixed Methods Approach in Educational Sciences Regarding Teacher Retention Intention in the Asian Context
Authors: Adhikari Basanta Pd , Adhikari Ramesh 
Published: April 2023

The primary objective of this study was to evaluate the different models of the mixed methods approach along with research problems, questions, and data analysis techniques and to review its overall methodology applied to collect data in a selected educational article. A mixed methods approach is a newly emerged research design of this 21st century where both quantitative and qualitative data can be collected one at a time. This study was based on the review of different articles, books, cases, magazines, and newspapers connecting with the mixed methods approach. The key focus of this study was to introduce the mixed methods approach, quantitative and qualitative approaches, evaluate the theoretical strengths and weaknesses of the mixed methods approach, and explicit meaning of both qualitative and quantitative design and its applications in the different fields of research studies.
The results indicate that the study has covered different aspects of the mixed methods approach along with the theoretical weaknesses of the mixed methods approach. The results have also focused on both quantitative and qualitative research approaches along with the mixed methods approach and different designs of the mixed methods approach. The results further indicate that the core designs of the mixed methods approach are contemporary development and expansion designs, the validity and reliability of the mixed methods approach, the generalization of research outcomes, and statistical generalization. It was indicated that the key findings and discussions were also focused on while reviewing different journals and online documents. The results suggest that factors affecting teacher retention and attrition intention were based on the high workload and unsupportive colleagues and administration, which are similar within China, Nepal, India, and Sri Lanka. The results show that approximately 42% of the teachers reported being highly stressed in China; the same scenario has also occurred in the Nepalese context. The implications of this study would be beneficial to young researchers, students, college teachers and master-level students to foreground the knowledge in the mixed methods approach.
Effective Contract in Higher Education: Intentions and Outcomes
Authors: Kurbatova M. V. , Donova I. V. 
Published: April 2023

The issue of the academic contract in the Russian higher education is associated with the salary systems reform in social sector and scientific field according to the adoption of the Decree of the President of the Russian Federation from May 7, 2012 No. 597 “On Measures for the Implementation of the State Social Policy”. Institutional project of the effective contract was aimed to solve two problems. Firstly, to raise the level of wages. Secondly, to its orientation to increase performance (i.e. outcomes-based payment). Over the past ten years in practice an effective contract evolved from innovation to university routine. On the other hand, researchers moved from substantiating approaches and elaborating methodologies to analyzing the experience of implementing an academic contract and then to evaluating its outcomes. The purpose of this study is to show the outcomes of the implementation of the effective contract project in the higher education system in two directions. Firstly, the achievement of target indicators for increasing the level of salaries of university teachers. Secondly, stimulating more efficient activities.Data from the Monitoring of higher education institutions effectiveness in 2021 is used in the study, and it includes data on 1222 universities. There is information on the average salary of university teachers (excluding part-time workers and civil contract staff) for 2020 for each educational institution, as well as on the ratio of teaching staff salary to the average salary in the region’s economy for 2016-2020. It was revealed that the task of introducing an effective contract for the increasing of salaries is generally being fulfilled but with significant difficulties due to the economic factors. The stimulating impact of an effective contract on the activities of university teachers is realized in conjunction with the solution of the tasks of increasing the effectiveness of the functioning of the universities themselves.
Kontribusi Kecerdasan Emosional terhadap Konflik Persahabatan pada Siswa SMP Negeri 1 Puding Besar, Bangka
Authors: Nitary Gian , Komarudin Komarudin 
Published: April 2023

Characteristics of friendships are spending time together, interacting in diverse contexts, distancing others from the relationship, and offering emotional support to one another. But in friendship there are often conflicts. Conflict is a social phenomenon that can happen to anyone and anywhere. To resolve conflicts and disputes that occur with friends, teenagers are required to be able to control their emotions. Adolescents who are able to reduce and control emotions can be seen from the emotional intelligence of adolescents. Correct emotional balance, satisfaction classification, and mood regulation are all possible with emotional intelligence. This study uses a quantitative research methodology. In this study, the quantitative method was applied with a correlational approach. This research was conducted at SMP Negeri 1 Puding Besar with a population of 350 students, but the researchers took a sample of 50 students. The sampling technique is purposive sampling. Data retrieval by filling in the scale. Data analysis using Pearson Correlation Product Moment. The results of this study found that the contribution of emotional intelligence to friendly conflict obtained a significant level < 0.001 < 0.05 with a correlation coefficient of 0.494, meaning that emotional intelligence has a correlation with friendly conflict. The contribution of emotional intelligence to friendly conflict is a negative relationship, so it can be assumed that the higher the emotional intelligence, the lower the friendship conflict.
Keywords: Emotional Intelligence, Friendship Conflict
An Artificial Intelligence Algorithm to Optimize the Classification of the Hepatitis Type
Authors: Hathal Khalil Hiba , Manfi Rada Sabah 
Published: April 2023

Hepatitis is one of the diseases that has become more developed in recent years in terms of the high number of infections. Hepatitis causes inflammation that destroys liver cells, and it occurs as a result of viruses, bacteria, blood transfusions, and others. There are five types of hepatitis viruses, which are (A, B, C, D, E) according to their severity. The disease varies by type. Accurate and early diagnosis is the best way to prevent disease, as it allows infected people to take preventive steps so that they do not transmit the difference to other people, and diagnosis using artificial intelligence gives an accurate and rapid diagnostic result. Where the analytical method of the data relied on the radial basis network to diagnose the disease, in addition to using the classification of the regression tree as well as the use of the genetic algorithm to improve the classification accuracy of both methods and by comparing the methods used to find out the most efficient methods of classification through criteria. Classification error, mean square root error, and average absolute relative error, and concluded that the experimental results are that the methods are good in terms of classification, as they gave results with less classification of error, and that the radial basis network was superior to the classification regression tree, and that the addition of the genetic algorithm led to an improvement classification accuracy.
Paper type: Research paper.
INHERITANCE DISTRIBUTION OF KHUNTSA MUSYKIL (EFFEMINATE)
Authors: Abizar Muhammad Hafidz , Al Amin Habibi 
Published: April 2023

This article is result of library research with a normative legal approach. Legal materials and data were obtained from Islamic legal norms regarding inheritance and khuntsa obtained from the texts of the Qur'an and Hadith, as well as the opinions of the jurists. This thesis discusses the distribution of khuntsa inheritance based on the opinion of Imam Ali As-Shobuni and Imam Abu Hanifah. People who do not have a clear gender status, not male and not female, are called khuntsa in Islamic law. One of the problems of khuntsa is in determining the right of inheritance. The Qur'an does not clearly state the portion of khuntha inheritance. This study concludes that in the unclear gender of khuntsa, it can be determined by two things, namely first, signs of maturity and second, where does urine come from. This argument is put forward using the istidlal theory used by Imam Ali As-Shobuni and Imam Abu Hanifah. If a khuntsa has a clear gender status, then this status follows the law of inheritance
Keyword : Khuntha mushkil, gender, inheritance.

DAFTAR PUSTAKA
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Hemocompatibility of cellulose phosphate aerogel membranes with potential use in bone tissue engineering
Authors: Schimper Christian B. , Pachschwöll Paul , Maitz Manfred F. , Werner Carsten , Rosenau Thomas , Liebner Falk 
Published: April 2023

Cellulose is an appealing material for tissue engineering. In an attempt to overcome some obstacles with cellulose II cell scaffolding materials related to insufficient biomineralization, lack of micron-size porosity, and deficiency in surface charge, respective solutions have been proposed. These included covalent phosphorylation of different cellulose materials targeting relatively low degrees of substitution (DS 0.18–0.23) and processing these cellulose derivatives into scaffolding materials by a dissolution/coagulation approach employing the hitherto rarely used TBAF/DMSO/H2O system for cellulose dissolution. Here, we report bioactivity and preliminary hemocompatibility testing of dual-porous cellulose phosphate aerogels (contrasted with the phosphate-free reference) obtained via coagulation (water/ethanol), solvent exchange and scCO2drying. Deposition of hydroxyapatite from simulated body fluid (7 days of immersion) revealed good bioactivity (1.5–2.2 mg Ca2+per mg scaffold). Incubation of the scCO2-dried and rehydrated scaffolding materials in heparin anticoagulated human whole blood was conducted to study selected parameters of hemostasis (prothrombin F1+2 fragment, PF4, count of thrombocyte-leukocyte conjugates) and inflammatory response (C5a fragment, leukocyte activation marker CD11b). Adhesion of leukocytes on the surface of the incubated substrates was assessed by scanning electron and fluorescence microscopy (DAPI staining). The results suggest that phosphorylation at low DS does not increase platelet activation. However, a significant increase in platelet activation and thrombin formation was observed after a certain fraction of the negative surface charges had been compensated by Ca2+ions. The combination of both phosphorylation and calcification turned out to be a potent means for controlling the inflammatory response, which was close to baseline level for some of the studied samples.
NIR-II fluorescence microscopic bioimaging for intrahepatic angiography and the early detection of Echinococcus multilocularis microlesions
Authors: Alifu Nuernisha , Yan Ting , Li Jun , Zhu Lijun , Aini Abudusalamu , Amuti Siyiti , Wu Juan , Qi Wenjing , Guo Gang , Zhang Wenbao , Zhang Xueliang 
Published: April 2023

Hepatic alveolar echinococcosis (HAE) is caused by the metacestode of Echinococcus multilocularis, which shows characteristics of malignant tumors with high mortality. However, traditional diagnostic imaging methods are still not sufficient for the recognition of HAE microlesions in the early stages. Near-infrared-II (900–1700 nm, NIR-II) fluorescence microscopic imaging (NIR-II-FMI) has shown great potential for biomedical detection. A novel type of negative target imaging method based on NIR-II-FMI with the assistance of indocyanine green (ICG) was explored. Then, NIR-II-FMI was applied to the early detection of HAE for the first time. The negative targeting NIR-II fluorescence imaging of HAE-infected mice at different stages with the assistance of ICG under 808 nm of laser irradiation was obtained. Especially, HAE microlesions at the early stage were detected clearly. Moreover, clear intrahepatic angiography was achieved under the same NIR-II-FMI system.
Genomic features, antimicrobial susceptibility, and epidemiological insights into Burkholderia cenocepacia clonal complex 31 isolates from bloodstream infections in India
Authors: Saroha Tanu , Patil Prashant P. , Rana Rekha , Kumar Rajesh , Kumar Sanjeet , Singhal Lipika , Gautam Vikas , Patil Prabhu B. 
Published: April 2023

IntroductionBurkholderia cepacia complex (Bcc) clonal complex (CC) 31, the predominant lineage causing devastating outbreaks globally, has been a growing concern of infections in non-cystic fibrosis (NCF) patients in India. B. cenocepacia is very challenging to treat owing to its virulence determinants and antibiotic resistance. Improving the management of these infections requires a better knowledge of their resistance patterns and mechanisms.MethodsWhole-genome sequences of 35 CC31 isolates obtained from patient samples, were analyzed against available 210 CC31 genomes in the NCBI database to glean details of resistance, virulence, mobile elements, and phylogenetic markers to study genomic diversity and evolution of CC31 lineage in India.ResultsGenomic analysis revealed that 35 isolates belonging to CC31 were categorized into 11 sequence types (ST), of which five STs were reported exclusively from India. Phylogenetic analysis classified 245 CC31 isolates into eight distinct clades (I-VIII) and unveiled that NCF isolates are evolving independently from the global cystic fibrosis (CF) isolates forming a distinct clade. The detection rate of seven classes of antibiotic-related genes in 35 isolates was 35 (100%) for tetracyclines, aminoglycosides, and fluoroquinolones; 26 (74.2%) for sulphonamides and phenicols; 7 (20%) for beta-lactamases; and 1 (2.8%) for trimethoprim resistance genes. Additionally, 3 (8.5%) NCF isolates were resistant to disinfecting agents and antiseptics. Antimicrobial susceptibility testing revealed that majority of NCF isolates were resistant to chloramphenicol (77%) and levofloxacin (34%). NCF isolates have a comparable number of virulence genes to CF isolates. A well-studied pathogenicity island of B. cenocepacia, GI11 is present in ST628 and ST709 isolates from the Indian Bcc population. In contrast, genomic island GI15 (highly similar to the island found in B. pseudomallei strain EY1) is exclusively reported in ST839 and ST824 isolates from two different locations in India. Horizontal acquisition of lytic phage ST79 of pathogenic B. pseudomallei is demonstrated in ST628 isolates Bcc1463, Bcc29163, and BccR4654 amongst CC31 lineage.DiscussionThe study reveals a high diversity of CC31 lineages among B. cenocepacia isolates from India. The extensive information from this study will facilitate the development of rapid diagnostic and novel therapeutic approaches to manage B. cenocepacia infections.
Diazoxide is a powerful cardioprotectant but is not feasible in a realistic infarct scenario
Authors: Kleinbongard Petra , Lieder Helmut , Skyschally Andreas , Heusch Gerd 
Published: April 2023

IntroductionDiazoxide is a powerful cardioprotective agent that activates mitochondrial ATP-dependent K-channels and stimulates mitochondrial respiration. Diazoxide reduced infarct size in isolated rodent heart preparations and upon pretreatment in juvenile pigs with coronary occlusion/reperfusion. We aimed to study the use of diazoxide in a more realistic adult pig model of reperfused acute myocardial infarction when diazoxide was administered just before reperfusion.Methods and resultsIn a first approach, we pretreated anaesthetised adult Göttingen minipigs with 7 mg kg−1 diazoxide (n = 5) or placebo (n = 5) intravenously over 10 min and subjected them to 60 min coronary occlusion and 180 min reperfusion; blood pressure was maintained by use of an aortic snare. The primary endpoint was infarct size (triphenyl tetrazolium chloride staining) as a fraction of area at risk; no-reflow area (thioflavin-S staining) was the secondary endpoint. In a second approach, diazoxide (n = 5) was given from 50 to 60 min coronary occlusion, and blood pressure was not maintained. There was a significant reduction in infarct size (22% ± 11% of area at risk with diazoxide pretreatment vs. 47% ± 11% with placebo) and area of no-reflow (14% ± 14% of infarct size with diazoxide pretreatment vs. 46% ± 20% with placebo). With diazoxide from 50 to 60 min coronary occlusion, however, there was marked hypotension, and infarct size (44% ± 7%) and area of no-reflow were not reduced (35% ± 25%).ConclusionsCardioprotection by diazoxide pretreatment was confirmed in adult pigs with reperfused acute myocardial infarction but is not feasible when diazoxide is administered in a more realistic scenario before reperfusion and causes hypotension.
Study of deformation law and support design feasibility of right-angled trapezoidal roadways
Authors: Chen Feng , Wang Xuebin , Bai Xueyuan 
Published: April 2023

Given the problems of serious asymmetric deformation and the difficulty in supporting right-angled trapezoidal roadways during the mining process, we established a mechanical model of surrounding rock for a right-angled trapezoidal roadway, determined the relationship between the deflection and tilt angle of the roadway roof, and determined that the typical failure mode of right-angled trapezoidal roadways is the upper slip of the high side. Two optimized support schemes are proposed, in which a constant resistance large deformation (CRLD) bolt + ordinary I-steel or a portal energy absorbing hydraulic (PEAH) support + ordinary bolt is used as the main support instead of an ordinary bolt + ordinary I-steel. Numerical simulation analysis shows that the aforementioned optimized support schemes can reduce the deformation, acoustic emission (AE) quantity, and AE energy of rock surrounding roadways and change how surrounding rock releases energy from main earthquake type to swarm earthquake type. The support scheme with CRLD bolt + ordinary I-steel or PEAH support + ordinary bolt as the main support can reduce the deformation of a roadway’s high side to 0.192 and 0.145 m, respectively. This shows that the two optimized schemes can effectively improve the overall bearing capacity and integrity of the rock surrounding roadways, which can be applied in the field.