bluuebunny/crossref_metadata_2025_split huggingface dataset:
ENVASARC: A pivotal trial of envafolimab and envafolimab in combination with ipilimumab in patients with advanced or metastatic undifferentiated pleomorphic sarcoma or myxofibrosarcoma who have progressed on prior chemotherapy.
Authors: Riedel Richard F. , Chawla Sant P. , Druta Mihaela , Jones Robin Lewis , Schuetze Scott , Lam Joelle , Zhuang Dongliang , Freddo James L. , Adams Bonne J. , Theuer Charles P. , D'Angelo Sandra P. 
Published: June 2023

TPS11583 Background: Metastatic undifferentiated pleomorphic sarcoma (UPS) and the genetically related myxofibrosarcoma (MFS) are soft tissue sarcoma (STS) subtypes with poor prognoses. While responses to first-line chemotherapy can approach 20%, efficacy remains limited in the 2nd-line setting and beyond. Pazopanib, the only FDA approved treatment in the refractory setting, has demonstrated an objective response rate (ORR) of 4%. Envafolimab is a single domain PD-L1 antibody administered by rapid subcutaneous (SQ) injection that is approved for the treatment of microsatellite instability-high (MSI-H) cancer in China. The activity of envafolimab appears to be similar to other PD-1 antibodies administered intravenously (i.v.). Envafolimab demonstrated a 32% ORR in MSI-H colorectal cancer patients with progressive disease following three approved chemotherapeutics, similar to the ORR of 28% and 33% with nivolumab and pembrolizumab in these patients, respectively. The rationale for the ENVASARC is based on envafolimab activity in STS in phase 1 trials and previously reported activity of checkpoint inhibition in UPS/MFS: single-agent pembrolizumab demonstrated a 23% ORR, while the combination of nivolumab and ipilimumab demonstrated a 29% ORR in refractory UPS/MFS. Methods: ENVASARC (NCT 04480502) is a pivotal multicenter (at 30 U.S. and U.K. centers) open-label, randomized, non-comparative, parallel cohort study of envafolimab 600 mg every 3 weeks by SQ injection (n = 80) or envafolimab 600 mg every 3 weeks by SQ injection combined with ipilimumab 1 mg/kg every 3 weeks i.v. for four doses (n = 80) in patients with locally advanced, unresectable or metastatic UPS/MFS with disease progression on one or two lines of prior therapy. The primary objective of each of parallel cohort is to demonstrate an ORR with a lower limit of the 95% confidence interval that excludes 5.0% in each cohort. If ≥ 9 responders are observed among the 80 patients enrolled in each cohort, then the lower bound of the 95% confidence interval will exclude 5.0%. Secondary endpoints include duration of response, PFS and OS. Key inclusion criteria: ≤ 2 prior lines of therapy ([neo]adjuvant therapy excluded), ECOG ≤ 1. Clinical trial information: NCT04480502 .
A feasibility study of 177Lu-PSMA radioligand therapy alternated with radium-223 in patients with bone-metastatic, oligo-metastatic, hormone-sensitive prostate cancer after curative therapy: The DUET study.
Authors: Vis André , Ettema Rosemarijn , Hendrikse Harry , van der Gaag Suzanne , Oprea-Lager Daniela Elena 
Published: June 2023

TPS5113 Background: Previous randomized clinical trials have shown an improvement in overall survival in patients with metastatic castration resistant prostate cancer (mCRPC), who have already failed other therapies, treated with 177Lu-PSMA radioligand therapy (RLT). Although 177Lu-PSMA RLT has shown exciting treatment responses in men with mCRPC and suggests a low toxicity profile, it has not been widely investigated in patients with metastatic hormone-sensitive prostate cancer (HSPCa). As of today, treatment with systemic drugs is proof of concept in advanced or metastatic HSPCa, as well as in other cancer types, and leads to improved oncological outcome, potentially by eradicating micro-metastatic disease. As a bone-seeking calcium mimetic, Radium-223 (Ra-223) is incorporated into new bone stroma, predominantly within sclerotic metastatic deposits. The high-energy of the alpha-particle radiation generates double-stranded DNA breaks, offering a potent and highly localized cytotoxic effect in the target areas. In a phase 3, randomized, double-blind, placebo-controlled study, Ra-223 has proven to significantly improve overall survival (by a treatment comprising 1 injection per month, at a dose of 50 kBq per kilogram of body weight intravenously), as compared with placebo. The optimal therapy in patients with oligometastatic bone HSPCa after previous curative treatment has not yet been defined. Methods: This is a single center, interventional, one-arm phase I-II study that prospectively investigates if a treatment strategy in which two types of cytotoxic RLT, i.e., an alpha-emitter and a beta-emitter, alternatively offered to patients with oligometastatic HSPCa, is feasible and safe. Eight patients with low volume, PSMA expressing, radiological progressive HSPCa (minimal 2 bone metastases, maximal 5, and at 0 to 3 lymph node metastases) will be recruited. In these patients, loco-regional radiotherapy or surgery is not an option anymore. The PSA doubling time in participating patients should be less than 6 months. Primary endpoint: To assess the feasibility and safety in patients with bone metastatic, oligometastatic HSPCa, treated by Ra-223 RLT alternated with 177Lu-PSMA RLT Secondary endpoints: Toxicity and (serious) adverse events will be monitored and reported in concordance with the NCI CTCAE v5.0; Assessment of the xerostomia inventory; Prostate-specific antigen (PSA) levels on follow-up at 3, 6 and 12-months; Investigative Treatment: Patients enrolled in the trial will receive three intravenous applications of Radium-223, in a dose of 5.5 kBq/kg body weight at t = 0 weeks, t = 4 weeks and t = 8 weeks (±1), and two intravenous applications of 7.4 GBq 177Lu-PSMA RLT at t = 6 weeks and t = 12 weeks (±1). Clinical trial information: NL81658.029.22.
Chantal Akerman and the Cinéfille
Authors: Mitchell Elspeth 
Published: June 2023

Abstract
One of Akerman's lesser-known films, Portrait d'une jeune fille de la fin des années 60 à Bruxelles (Portrait of a Young Girl in the Late Sixties in Brussels, Belgium, 1993) provides a critical lens for discovering the cinéfille as a concept for Akerman's cinema and feminist film theory. Cinéfille is conceptually both similar to and different from its near homophone, cinéphile, and aligns the moving image (ciné) with the girl (fille). The article develops the concept in relation to three areas: the possibility of a cine-love before and beyond the masculine frame of cinephilia; Akerman's complex relation to her own cinematic becoming and cinema's historiography; and the distinct temporality and duration of cinema produced by and for the figure of the girl. The article demonstrates that in Akerman's filmmaking, the figure of girl as cinéfille is not a position of resistance, nor a scene of perpetual adolescence, but a positive queer feminist creative engagement with the possibility of new forms of knowing, relating, and desiring. Attending to the emergence of the cinéfille and cinefillia allows us to articulate a sense of looking back that is not simply tied to nostalgia and loss. It also reveals a moment of creative discovery and intensity that emerges in the durational aesthetic form for which Akerman's cinema is well known. The cinéfille is a form of becoming realized in cinema.
Novel Standalone Motion-Sparing Pelvic Fixation Prevents Short-Term Insufficiency Fractures After Midsacrectomies Without Sacrificing Normal, Mobile Lumbar Segments Traditionally Used for Stabilization
Authors: Lo Sheng-fu Larry , Pieters Thomas A , Hersh Andrew M. , Green Ross , Suk Ian , Pennington Zach , Elsamadicy Aladine A , Sciubba Daniel M 
Published: June 2023

BACKGROUND AND OBJECTIVES:
Sacrectomy is often the treatment of choice to provide the greatest chance of progression-free and overall survival for patients with primary malignant bone tumors of the sacrum. After midsacrectomy, the stability of the sacropelvic interface is diminished, resulting in insufficiency fractures. Traditional stabilization involves lumbopelvic fixation but subjects normal mobile segments to fusion. The purpose of this study was to determine whether standalone intrapelvic fixation is a safe adjunct to midsacrectomy, avoiding both sacral insufficiency fractures and the morbidity of instrumenting into the mobile spine.

METHODS:
A retrospective study identified all patients who underwent resection of sacral tumors at 2 comprehensive cancer centers between June 2020 and July 2022. Demographic, tumor-specific, operative characteristics and outcome data were collected. The primary outcome was presence of sacral insufficiency fractures. A retrospective data set of patients undergoing midsacrectomy without hardware placement was collected as a control.

RESULTS:
Nine patients (5 male, 4 female), median age 59 years, underwent midsacrectomy with concomitant placement of standalone pelvic fixation. No patients developed insufficiency fractures during the 216 days of clinical and 207 days of radiographic follow-up. There were no adverse events attributable to the addition of standalone pelvic fixation. In our historical cohort of partial sacrectomies without stabilization, there were 4/25 patients (16%) with sacral insufficiency fractures. These fractures appeared between 0 and 5 months postoperatively.

CONCLUSION:
A novel standalone intrapelvic fixation after partial sacrectomy is a safe adjunct to prevent postoperative sacral insufficiency fractures in patients undergoing midsacrectomy for tumor. Such a technique may allow for long-term sacropelvic stability without sacrificing mobile lumbar segments.
LOGÍSTICA E AGRICULTURA: O PAPEL DOS INVESTIMENTOS EM INFRAESTRUTURA PARA O AVANÇO DA PRODUÇÃO DE SOJA NO CERRADO
Authors: Lima Costa Everton , Abner Matheus João Abner , Caixeta-Filho José Vicente , Péra Thiago Guilherme 
Published: June 2023

O Cerrado é o segundo maior bioma brasileiro, ocupando 24% do território nacional. As áreas cobertas pela vegetação desse bioma se tornaram as principais regiões produtoras de soja no país, a partir da segunda metade do século passado. Dentre os obstáculos para essa expansão da atividade está a defasada estrutura logística, que dependente do modal rodoviário para o transporte da produção, é um grande entrave para a competitividade do agronegócio brasileiro. Frente a esse cenário, de importância de maiores investimentos em logística, o objetivo principal deste trabalho é indicar quais os principais determinantes para o avanço da área cultivada de soja nos municípios produtores do Cerrado, com ênfase no papel dos investimentos em infraestrutura logística, representados pelos investimentos públicos em rodovias, no crescimento da área produzida. Para isso, foram estimados modelos econométricos de painéis de dados dinâmicos, por meio de System GMM. Os dados são de 880 municípios, para a década de 2008 até 2017. Os resultados apontam que aumentos no investimento em rodovias são determinantes positivos e estatisticamente significantes para o aumento da área cultivada. Além dessa variável, os resultados apontam que o desempenho econômico da atividade apresenta efeito positivo sobre o aumento da área, bem como a densidade populacional, efeitos negativos. Foram consideradas ainda variáveis referentes ao desmatamento e rebanhos de bovinos, para o período corrente e anterior.
Clinical manifestations of Graves’ disease among adults - a review of literature
Authors: Skoczylas Kamila , Rokicki Sebastian , Schok Katarzyna , Mikulska Julia 
Published: June 2023

Introduction: The most common cause of hyperthyroidism among adults is Graves' disease. The symptoms that occur in the course of this disease affect various systems and organs, including the skin, eyes, cardiovascular system, nervous system and respiratory system.
The aim of the study: The aim of the work was to review available publications and materials and present the current state of knowledge on possible symptoms of Graves' disease among adults.
Material and method: A review of publications available in the PubMed database was conducted. Articles were searched in English using keywords such as Graves' disease, hyperthyroidism, thyrotoxicosis, thyroid disease. Subsequently, works related to the subject of the publication were selected.
Conclusions: Graves' disease is a fairly common endocrine disorder, but its diagnosis can be delayed due to the variety and non-specificity of symptoms. In untreated cases, hyperthyroidism can lead to a life-threatening condition. Effective antithyroid drugs are available, so it is important to remain vigilant and recommend monitoring thyroid function tests if there are suspicions of its dysfunction.
Knee injuries in volleyball - a review of the articles
Authors: Zwolski Maciej , Puchalski Krzysztof , Szumlas Zuzanna , Klocek Konrad , Kostecki Bartosz , Jurek Aleksander , Mrozek Łukasz , Hajduk Aleksandra 
Published: June 2023

Introduction and purpose: The aim of this study is to review and analyze scientific research on the topic of volleyball injuries. We attempt to identify the types of injuries that are characterized by increased frequency, diagnostic possibilities, and treatment methods. We believe that this work can support individuals involved in sports and sports medicine personnel in accessing information more quickly and facilitate the direction of further research into preventing injuries among volleyball players.
State of Knowledge: Knee injuries are divided into overload and acute injuries. Overload syndromes include degenerative changes to the patellar ligament. Medical history and physical exam suffice for accurate diagnosis. Treatment for jumper’s knee is based mostly on conservative treatment. Meniscus injuries are equally common such as ACL rupture. Not all meniscus injuries require surgery, and the key factor in making a decision is the pattern of tearing and the presence of appropriate vascularization.
Conclusions: Based on analyzed studies we assumed that every third serious injury among volleyball players is the knee injury. There is no single preferred method of treatment. Early diagnosis and intervention are crucial to prevent the progression of the disease. Stretching and eccentric strengthening exercises are recommended in the early stages. Efficiency of platelet-rich plasma injections remains uncertain. Further research is needed to determine the most effective treatment. In acute knee injuries, ACL damage often coexists. Treatment for such injuries typically involves surgical intervention. Arthroscopy is the preferred method. Meniscus repair has a high success rate and enables a rapid return to physical fitness.
“Addressing the bigger picture”: A qualitative study of internal medicine patients’ perspectives on social needs data collection and use
Authors: Davis Victoria H. , Dainty Katie N. , Dhalla Irfan A. , Sheehan Kathleen A. , Wong Brian M. , Pinto Andrew D. 
Published: June 2023

Background
There is increasing interest in collecting sociodemographic and social needs data in hospital settings to inform patient care and health equity. However, few studies have examined inpatients’ views on this data collection and what should be done to address social needs. This study describes internal medicine inpatients’ perspectives on the collection and use of sociodemographic and social needs information.

Methods
A qualitative interpretive description methodology was used. Semi-structured interviews were conducted with 18 patients admitted to a large academic hospital in Toronto, Canada. Participants were recruited using maximum variation sampling for diverse genders, races, and those with and without social needs. Interviews were coded using a predominantly inductive approach and a thematic analysis was conducted.

Results
Patients expressed that sociodemographic and social needs data collection is important to offer actionable solutions to address their needs. Patients described a gap between their ideal care which would attend to social needs, versus the reality that hospital-based teams are faced with competing priorities and pressures that make it unfeasible to provide such care. They also believed that this data collection could facilitate more holistic, integrated care. Patients conveyed a need to have a trusting and transparent relationship with their provider to alleviate concerns surrounding bias, discrimination, and confidentiality. Lastly, they indicated that sociodemographic and social needs data could be useful to inform care, support research to inspire social change, and assist them with navigating community resources or creating in-hospital programs to address unmet social needs.

Conclusions
While the collection of sociodemographic and social needs information in hospital settings is generally acceptable, there were varied views on whether hospital staff should intervene, as their priority is medical care. The results can inform the implementation of social data collection and interventions in hospital settings.
Study on the photoelectrocatalytic activity of reduced TiO2 nanotube films for removal of methyl orange
Authors: Thi Thanh Thuy Mai , Thi Van Anh Nguyen , Thi Xuan Mai , Vinh Tran Quang , Thi Binh Phan 
Published: June 2023

Abstract
The reduced TiO2 film on which a photoelectrocatalytic (PEC) process had occurred was created from TiO2 nanotube film electrodes by the electrochemical reduction method. The obtained samples’ structure and morphology were characterized using UV-Vis diffuse reflectance spectroscopy, scanning electron microscopy, high-resolution transmission electron microscopy, photoluminescence, and X-ray diffraction. Cyclic voltammetry, linear sweep voltammetry, electrochemical impedance spectroscopy, chronoamperometry, UV-Vis absorbance spectroscopy, and Mott–Schottky plots were employed to examine the electrochemical and photoelectrochemical activities of the prepared electrodes. The results showed that the optimal conditions of cathodic polarization were a potential of −1.4 V for 60 min. The reduced TiO2 nanotube film electrode had better photoelectrochemical activities than pristine TiO2 under UV light due to the higher photocurrent density (13.7 mA‧cm−2) at 1.5 V (vs Ag/AgCl, sat. KCl reference electrode) compared to pristine TiO2 achieving 7.3 mA‧cm−2, indicating more effective charge separation and transport. The degradation of methyl orange (MO) on pristine TiO2 and reduced TiO2 electrodes was carried out in electrocatalytic (EC) and PEC conditions. The PEC process on the reduced TiO2 electrode had the highest MO processing efficiency (98.4%), and the EC process for MO removal on reduced TiO2 had higher efficiency (95.1%) than the PEC process on pristine TiO2 (89.2%).
A rare cause of hyperphenylalaninemia: four cases from a single family with DNAJC12 deficiency
Authors: Gunes Dilek , Senturk Leyli 
Published: June 2023

Abstract

Objectives
DNAJC12 deficiency (OMIM# 617384) is a new cause of hyperphenylalaninemia (HPA). The deficiency of the co-chaperone protein DNAJC12 was identified in 2017. To date, only 43 patients have been reported. Here, we report four patients from a single family with DNAJC12 deficiency while being followed up with a diagnosis of HPA.

Case presentation
Two of the patients, who were cousins, were diagnosed with HPA by newborn screening. And the other two patients were siblings of these patients. Neurological examinations were normal except for one patient with mild learning disability. A c.158-2A>T p.(?) biallelic pathogenic variant was detected in intron 2 of the DNAJC12 gene. In the 24 h tetrahydrobiopterin (BH4) challenge test, there was a significant decrease in phenylalanine levels, especially at the 16th hour. Three patients had decreased homovalinic acid (HVA) and 5-hydroxyindoleacetic acid (5HIAA) in cerebrospinal fluid (CSF), while only one had decreased 5HIAA. In treatment, sapropterin, levodopa/carbidopa and 5-OH tryptophan were started.

Conclusions
We propose that it will be beneficial to evaluate the patients who have unexplained hyperphenylalaninemia for DNAJC12 deficiency. Patients with early diagnosis of neurotransmitter deficiency may be given a chance to be treated before clinical symptoms begin.
Uric acid and sCD163 as biomarkers for metabolic dysfunction and MAFLD in children and adolescents with overweight and obesity
Authors: Orry Sofie , Dalstrup Jakobsen Dorthe , Kristensen Nickolai Malte , Meldgaard Bruun Jens 
Published: June 2023

Abstract

Objectives
The prevalence of childhood obesity increases globally, and noninvasive methods are needed to identify metabolic dysfunction and obesity-related complications such as pediatric metabolic associated fatty liver disease (MAFLD). We investigated whether uric acid (UA) and the macrophage marker soluble form of cysteine scavenger receptor CD163 (sCD163) can be used as biomarkers for deteriorated metabolism or pediatric MAFLD in children with overweight or obesity.

Methods
Cross-sectional clinical and biochemical data from 94 children with overweight or obesity was included. Surrogate liver markers were calculated, and correlations were investigated using Pearson’s or Spearman’s correlation test.

Results
UA and sCD163 correlated with BMI standard deviation score (r=0.23, p<0.05; r=0.33, p<0.01) and body fat (r=0.24, p<0.05; r=0.27, p=0.01). UA correlated with triglycerides (ρ=0.21, p<0.05), fat free mass (r=0.33, p<0.01), and gamma-glutamyl transferase (r=0.39, p<0.01). sCD163 correlated with the pediatric NAFLD fibrosis score (r=0.28, p<0.01) and alanine aminotransferase (r=0.28, p<0.01). No correlation was found between UA and pediatric MAFLD.

Conclusions
UA and sCD163 was identified as markers of a deranged metabolic profile, thus acting as easily accessible biomarkers for obesity and an obesity-related deranged metabolism. Furthermore, increasing levels of sCD163 could be a useful biomarker of pediatric MAFLD. Future prospective studies are warranted.
A versatile dynamic noise control framework based on computer simulation and modeling
Authors: Li Jie , Zhang Zonglu 
Published: June 2023

Abstract
This article attempts to effectively reduce the impact of active noise pollution on human life, and to make up for the traditional passive noise control technique. In low-frequency noise control, there are some shortcomings. The making of active noise control (ANC) technique, in low-frequency noise reduction, can achieve very good results. This article proposes a versatile dynamic noise control framework based on computer simulation and modeling. The research is mainly focused on the principle and application of versatile dynamic noise control framework. To accomplish this, a research method combining theoretical analysis, software simulation, and hardware realization is adopted. The derivation process of the adaptive algorithm (LMS algorithm, filter-XLMS algorithm, etc.) is introduced in detail, and the influencing factors of algorithm performance, a variable step size normalization algorithm based on relative error is proposed. Perform simulation calculations on various algorithms in MATLAB, analyze parameters such as step factor, filter order, etc., and the degree of influence on the algorithm’s convergence speed and steady-state performance. Common command set software is used, the path adaptive identification is realized, and the program design of the versatile dynamic noise control framework is used. After completion of software and hardware debugging on the experimental platform of generalized comfort, the experimental equipment layout is completed. Using the additive random noise method, the adaptive offline modeling of the first path of the versatile dynamic noise control framework is realized. Finally, utilizing the experimental platform of generalized comfort, the adaptive ANC experiment of the single-channel filtered least mean square algorithm is conducted, then the experimental data are analyzed, and at last, the actual application effect of the versatile dynamic noise control framework is verified.