bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN METODE PROBLEM BASED INSTRUCTION (PBI ) DALAM UPAYA MENINGKATKAN PRESTASI BELAJAR IPA PADA MATERI PEWARISAN SIFAT MAKHLUK HIDUP SISWA KELAS IX DI UPT SMP NEGERI 22 GRESIK
Authors: Moerniningsih  
Published: August 2023

The purpose of this study was to improve the learning outcomes of fifth-grade students through the Problem Based Instruction (PBI). The research used was classroom action research (PTK) with a type of collaborative research and carried out in two cycles. Each cycle consists of 4 stages, namely planning, implementation, observation, and reflection and carried out in 3 meetings. The subjects in the study consisted of 17 students consisting of 15 male students and 11 female students. The data analysis technique used is the data analysis of the observation sheet used to determine the feasibility of the learning model and student learning outcomes in science learning. Based on the results of this study, the results of the implementation of the learning model increased in each cycle I by 75,05% in the sufficient category to be 84,86 % in the second cycle in the good category. While the percentage of completeness of student learning outcomes in the first cycle amounted to 85 % and in the second cycle the percentage of student learning completeness increased by 90 %. It can be concluded that by applying the model PBI for students at UPT SMP Negeri 22 Gresik

Abstrak
Tujuan penelitian ini untuk meningkatkan prestasi belajar siswa melalui penerapan model Problem Based Instruction (PBI) pada mata pelajaran IPA di UPT SMP Negeri 22 Gresik. Metode penelitian yang digunakan adalah penelitian tindakan kelas (PTK) dengan jenis penelitian kolaborasi dan dilaksanakan sebanyak dua siklus. Setiap siklusnya terdiri dari 4 tahapan yaitu perencanaan, pelaksanaan, observasi, dan refleksi dan dilaksankan dalam 3 pertemuan. Subjek dalam penelitian terdiri dari 32 siswa yang terdiri dari 17 siswa laki-laki dan 15 siswa perempuan. Teknik analisis data yang digunakan yaitu analisis data lembar observasi dan tes yang digunakan untuk mengetahui keterlaksanaan model pembelajaran dan hasil belajar siswa dalam pembelajaran IPA. Berdasarkan hasil penelitian ini, diperoleh hasil keterlaksanaan model pembelajaran mengalami peningkatan di setiap siklus I sebesar 75,05 % dalam kategori cukup menjadi 84,86% pada siklus II dalam kategori baik, sedangkan persentase ketuntasan hasil belajar siswa pada siklus I sebesar 85 % dan pada siklus II persentase kentuntasan belajar siswa meningkat sebesar 90 %. Hal ini dapat disimpulkan bahwa dengan menerapkan model PBI dapat meningkatkan hasil belajar IPA untuk siswa di UPT SMP Negeri 22 Gresik
Influence of CO and PES support modules on filtration performance of 3D printed Chitosan/AgNP/GO composite membranes
Authors: Ogazi Anthony , Osifo Peter O. 
Published: August 2023

Abstract

In this study, the effects of cotton (CO) and polyester (PES) fabric support modules on the filtration performance of Chitosan/silver nanoparticles/graphene oxide (CS/AgNP/GO) composite membranes modified with Dimethyl acetamide (DMAc) were investigated. The contact angle of the modified CS matrix decreased with proper blending of membrane composites, which improved fluid transport due to strongly bound water oxygen-containing functional groups present in the modified chitosan, according to the FTIR report. The experimental results revealed that both plain CO and PES fabrics can successfully serve as support modules for 3D printed CS/AgNP/GO composite membranes, increase water permeability, and effectively improve the filtration process. However, the effectiveness of the modified CS membrane separation process depends on the molecular interaction between the membrane composite structure and the support materials. The water absorbency of CO fabric is 16.3% higher than that of polyester (PES), confirming greater wettability. The CO-supported composite membranes exhibited the highest average permeation flux of 0.221 Lm− 2h− 1, while that of the PES-supported composite and unsupported modified CS membranes was 0.153 Lm− 2h− 1 and 0.127 Lm− 2h− 1, respectively, indicating that 100% plain CO and PES fabrics may serve as membrane support materials for water purification. Furthermore, the presence of particulate matter, including inactivated or active bacterial strains, on the membrane surface and low pressure could influence a reduction in permeation flux.
A one-pot chitosan pyrolysis in the presence of a ZnCl 2 /NaCl salts for carbons with electrocatalytic activity
Authors: Kochaniec Maria K. , Lieder Marek 
Published: August 2023

Abstract

The one-step carbonization of low cost and abundant chitosan biopolymer in the presence of salt eutectics ZnCl2/NaCl results in nitrogen-doped carbon nanostructures (8.5% total nitrogen content). NaCl yields the spacious 3D structure, which allows external oxygen to easily reach the active sites for the oxygen reduction reaction (ORR) distinguished by their high onset potential and the maximum turnover frequency of 0.132 e site⁻¹ s⁻¹. Data clearly show that the presence of NaCl during the synthesis exhibits the formation of pores having large specific volumes and surface (specific surface area of 1217.4 m2 g− 1), and holds advantage by their pores characteristics like their micro size part which provides platform for mass transport distribution in three-dimensional N-doped catalysts for ORR. It holds advantage over sample pre-treated with LiCl in terms of the micropores specific volume and area, seen as their percentage rate, measured in the BET. Thus, the average concentration of the active site on the surface is larger.
Association of hepcidin with serum lipids, triglyceride-glucose index, and High-sensitivity cardiac troponin T in Metabolic syndrome population
Authors: Wang Xiaona , Xiao Wenkai , Sheng Li , Ye Ping 
Published: August 2023

Abstract

Background
Hepcidin has been viewed as a reliable surrogate of cardiovascular disease (CVD) risk. We investigate the correlation between Hepcidin with serum lipids, triglyceride-glucose index, and High-sensitivity cardiac troponin T (Hs-cTnT) in community-based population by using Hs-cTnT as measuring indicator for myocardial injury.
Methods
We analyzed the association of baseline Hepcidin with serum lipids, triglyceride-glucose index, and Hs-cTnT levels in 1447 subjects from a community-based population in Beijing, China.
Results
There were significant differences in age, sex, smoking, SBP, HDL-C, LDL-C, Sd-LDL, PCSK9, LDL-TG, Apo EH, Lp(a), eGFR, hepcidin and Hs-cTnT between populations with or without Mets (P < 0.05). In correlation analysis, hepcidin was correlated with TG (β = 0.663; p = 0.002), sd-LDL (β = 9.893; p = 0.015), PCSK9 (β = 16.385; p < 0.001), RLP-C (β = 8.530; p = 0.011), LDL-TG (β = 4.652; p = 0.006), and TyG (r = 0.246; p < 0.001). Multiple linear regression analysis showed that baseline hepcidin (β = 0.584, 95%CI:0.236–0.932, P = 0.001) was positively correlated with follow-up Hs-cTnT levels in subjects with Mets. Additionally, HDL-C levels were negatively correlated with follow-up Hs-cTnT levels (β=−0.429, 95% CI: -0.791- -0.066, P = 0.021). In subjects with Mets, Logistics regression model showed that hepcidin was associated with elevated Hs-cTnT (HR = 2.534, 95%CI: 1.267–5.357, P < 0.05), but not for non-Mets group. Model 1 showed that high hepcidin was a risk factor for elevated Hs-cTnT independent of hepcidin, TG, Sd-LDL, PCSK-9, RLP-C, LDL-TG, Lp(a) and HDL-C in subjects with Mets (HR = 3.284; 95%CI: 1.015–10.634, P < 0.001).
Conclusions
Our findings in a Chinese cohort suggest that hepcidin is a risk factor for elevated Hs-cTnT in patients with Mets.
Case report: Pneumonia in an elderly Tibetan male caused by Shewanella algae
Authors: fu xiaohong , Huang Qian , feng huanxiang , gou wei 
Published: August 2023

Abstract
Background
Shewanella algae is a gram-negative bacterium that is widely found in aquatic habitats and rarely causes lung infections in inland areas.
Case presentation
This case report presents the clinical presentation and treatment of a 68-year-old Tibetan male who developed cough, phlegm, chills, fatigue, and shortness of breath. Laboratory tests showed elevated white blood cell count（WBC10030/ul） and procalcitonin levels（PCT0.067ng/ml）, and chest CT revealed scattered lesions. A gram-negative bacterium was isolated from lower respiratory tract specimens and identified as Shewanella algae using various techniques including BioMerieux VITEK 2 Compact, MALDI-TOF-MS (Autof ms1000), and 16S rRNA gene sequence analysis. The patient's lung infection improved after one week of treatment with ceftazidime, and he was discharged.
Conclusion
This case highlights a rare occurrence of lung infection caused by Shewanella algae in elderly Tibetan men residing in non-marine environments.
Bronchopulmonary foregut malformation with severe hemoptysis in advanced age: a case report and literature review
Authors: Cai Cheng-Sen , Yuan Yuchun , Li Bin , Fu Lina , Zhang Xiaoye , Wang Jun 
Published: August 2023

Abstract
Bronchopulmonary foregut malformation (BPFM) is a rare developmental malformation disease due to embryonic defects, with an even rarer occurrence in adults. We report a diagnosed case in an adult patient, and notably, this is the first reported case of such advanced age. Additionally, she experienced coughing up approximately 1 liter of blood and partial lung tissue, accompanied by respiratory failure and shock. Following treatment with transcatheter arterial embolization, her condition improved, and she has remained stable during follow-up. We present a case report and conducted a systematic review on this particular case.
MS-stability of the predator-free and positive equilibria for food chain model with vigilance under stochastic perturbations
Authors: Tan Jianguo , Jiang Xiao han 
Published: August 2023

Abstract
Most stability analyzes of SDE models are based on the construction of Lyapunov functions, but it is difficult to find suitable Lyapunov functions in some cases. This paper investigates a vigilant food chain model assuming that the model is subject to random perturbations proportional to deviations from the system state and equilibrium point. Using Kronecker product and semi-vectorization dimensionality reduction method, the explicit sufficient condition and stable region of asymptotically mean square(MS) stability of stochastic system are obtained. The influence of noise intensity and bi-parameters changes on the mean square stable region are analyzed. From the analysis, the following conclusions are obtained: mid-level predators are the most responsive to disturbance, while bottom prey are least sensitive to disturbance. Overall, the increase in perturbation reduces the MS-stable geometry volume and maximum resilience.
Advancing Emergency Preparedness, Resilience and Response through High-Fidelity Simulation: A scoping literature review.
Authors: Newton Jon , Critchley Anya 
Published: August 2023

Abstract
Background: The sudden or unexpected occurrence of major incidents presents challenging and unpredictable working environments for emergency service personnel. Effectively training those with a response role is therefore of fundamental importance and vital for embedding resilience within organisations. NHS England’s Emergency Preparedness, Resilience and Response (EPRR) Framework specifies the training requirements for responder organisations, yet limited guidance exists to support the educational quality or tangible outputs the table-top scenarios and live-play exercises should provide. In recent years, High-Fidelity Simulation (HFS) has gained recognition as an effective method for advancing clinical acumen within this domain, yet few studies have attempted to validate its capability for cultivating psychological readiness and mental resilience.
Methods: To further teaching and learning practices we conducted a scoping literature review to ascertain if skills in critical thinking, emotional preparedness and mental resilience might be developed through the utilisation of HFS for major incident training.
Findings: In all six studies returned by our search strategy, HFS was universally found to enhance critical thinking skills and decision-making. However, no studies have yet been conducted which formally evaluate developments in emotional preparedness and mental resilience.
Conclusion: A sparsity of high-ranking evidence currently exists to guide teaching and learning developments within major incident training; and a research-knowledge gap for developing emotional preparedness and mental resilience has been identified. Further targeted research is required to ascertain the true benefits of HFS and its potential role in supporting the EPRR Cycle of Preparedness.
Mutation mapping of PD-L1 expression in advanced non-small cell lung cancer: A real-world retrospective cohort study
Authors: Hao Fang , Ma Qing , Zhong Diansheng 
Published: August 2023

Abstract
Background:
The duration of response to immune checkpoint inhibitors (ICIs) varies because of tumor immune heterogeneity and employing programmed death receptor ligand 1 (PD-L1) expression to evaluate the efficacy of anti-programmed cell death-1 (PD-1)/PD-L1 antibodies remains controversial.
Experimental Design:
A total of 138 advanced non-small cell lung cancer (NSCLC) patients subdivided into 2 groups - 52 patients with a PD-L1 Expression≥50% and 86 patients with a PD-L1 Expression <50% - based on next-generation sequencing (NGS) to analyze multiple-dimensional data types, including tumor mutation burden (TMB), gene alterations, gene enrichment analysis, therapy response, and immune-related adverse events (irAEs).
Results:
High level of PD-L1 expression was significantly associated with advanced age and TMB status. The PD-L1≥50% cohort bear mutations of KRAS, NOTCH1, and FAT, while PD-L1<50% group exhibited mutations of EGFR, PTEN, or LATS1/2. Except the ascertained DNA damage response regulation, it seemed that Hippo-YAP signal played a potential role in mediating PD-L1 expression. Even though there was no significant difference between PD-L1≥50% and PD-L1<50% cohorts on therapy response, patients with a PD-L1 Expression≥50% eclicited high irAEs incidence rate and increased plasma interleukin 6 (IL-6) concentration.
Conclusions:
This real-world retrospective study suggested that high expression of PD-L1 exhibited dysfunction of Hippo signaling and collaborated with anti- cytokines and chemokines therapy may optimize clinical therapy efficacy.
Degradation of the wild fruit forest infulences the diversity of soil bacterial and fungal communities in the Tianshan Mountains
Authors: Rong Xiaoying , Wu Nan , Yin Benfeng , Zhou Xiaobing , Zhu Bingjian , Li Yonggang , Aanderud Zachary T. , Zhang Yuanming 
Published: August 2023

Abstract
Background and aims:
The wild fruit forest in the Tianshan Mountains is a vital reservoir of germplasm resources for improving the genetic diversity of temperate fruit trees worldwide. In recent years, however, this forest ecosystem has been seriously threatened by outbreaks of diseases and insect pests as well as climate change. Analyses of soil microbial community diversity following degradation of the forest could provide insights into its impact on soil quality and the ecosystem.
Methods
In this study, we applied 16S rRNA and ITS gene sequencing to analyze the microbial community composition of soil samples surrounding healthy and degraded Malus sieversii and also recorded soil physiochemical variables.
Results
we found that degradation of the wild fruit forest due to M. sieversii decline significantly reduced the beta diversity of topsoil bacterial communities and fungal symbiotic groups. The decline in M. sieversii loosened connections among bacterial and fungal co-occurrence networks. Analysis of community assemblies revealed that migration rates of bacteria and fungi were both higher in the topsoil around degraded M. sieversii, thus suggesting that dispersal restriction affects microbial species in the degraded wild fruit forest. Narrow niche-breadth bacterial species were preferentially selected by the decline in M. sieversii, leading in turn to more variation in fungal functional diversity (i.e., increased beta diversity of pathogenetic fungi but decreased diversities of symbiotic and saprotrophic fungi).
Conclusions
Our results show that degradation of M. sieversii lead to variations in microbial diversity and in the underlying function of forest microorganisms. The study offers the inclusion of microbial information during soil quality monitoring is crucial to gain a better, more accurate understanding of how degradation of M. sieversii impacts soil quality and the ecosystem.
The impact of the clinical pharmacists intervention on the appropriate antibiotic therapy of septic patients: a non-randomized controlled study
Authors: Sürmelioğlu Nursel , Demirkan Kutay , Karakoç Emre , Gündüz Murat , Özcengiz Dilek 
Published: August 2023

Abstract
Objective: Effective antimicrobial therapy is critical for the treatment of patients in the intensive care unit (ICU), especially septic patients. Early application of empirical therapy and subsequent de-escalation and appropriate dose selection are the three essential elements for optimal antimicrobial therapy. In this study, it was aimed to evaluate the impact of clinical pharmacists on antibiotic treatment of septic patients, and secondly, to determine drug-related problems in septic patients.
Methods: This study was conducted at ICU of a university hospital. Septic patients who were provided medication review service by a clinical pharmacist were assigned to the intervention group. The control group consists of patients who were not provided medication review service. Intervention and control group were compared in terms of, time to de-escalation, appropriateness of antimicrobial dosing, and drug treatment costs.
Results: 130 patients were included in the study to be divided equally between the intervention (prospective) and control groups (retrospective). 753 drug-related problems were detected in the intervention group. 644 intervention recommendations for these problems were presented to ICU team. Of these interventions, 298 (46.3%) were made for antimicrobial drugs. Statistically significant differences were found in comparison of time to de-escalation, appropriateness of the antimicrobial drug dosage, and antibiotic costs between the intervention and control groups (p£0.001).
Conclusion: A clinical pharmacist on the sepsis management team may help ensure that septic patients receive the optimal antibiotic therapy and the reduction of antibiotic costs.
Ameliorative Effect of Adhatoda Vasica Against Aflatoxicosis in Broiler Chicken
Authors: Muthusamy Sakthi Priya , Appusamy Jagadeeswaran , Amirthalingam Natarajan 
Published: August 2023

Abstract
Background : The effect of aflatoxin in broilers is well known. However dietary supplementation of crude leaf powder of Adhatoda vasica was found to decrease the negative effect of aflatoxin B1 because of bio-adsorbing feature of the active ingredient and the detoxifying nature of the herbal material. The main goal of this study was to ascertain how Adhatoda vasica crude leaf powder along with aflatoxin contaminated diet ameliorated the toxic effects of aflatoxin B1 on zootechnic performance indicators, bone morphometric characters, serum biochemistry, antioxidant profile, organ weights, gross pathology and histopathology of liver and kidney. Broiler chicks of one day old were divided into six groups. The G1 group was given a formulated basal diet without any supplements. The G2 group was fed with balanced diet with Adhatoda vasica crude leaf powder at 0.5 % inclusion. The G3 group was fed with balanced diet with aflatoxin B1 (50 µg/kg). The G4 group was fed with balanced diet with aflatoxin B1 (50 µg/kg) and Silymarin @1000mg/kg feed. The G5 was fed with balanced diet with aflatoxin B1 (50 µg/kg) and Adhatoda vasica crude leaf powder at 0.1 % and G6 was fed with balanced diet with aflatoxin B1 (50 µg/kg) and Adhatoda vasica crude leaf powder at 0.5 % inclusion from day 1 to day 35 of age.
Results: According to the results of the study, Aflatoxin supplementation in the feed had a detrimental impact on zootechnical performance, bone morphometric characters, serum biochemical parameters, gross and histopathology. Aflatoxin supplementation led to liver injury that was indicted by serum biochemistry and histopathology in the liver and kidney tissues. Supplementation of the crude leaf powder of Adhatoda vasica exhibited significant detoxifying effect as evidenced by improved growth performance and bone morphometric characters and ameliorating changes in the levels of serum biochemical parameters and the antioxidant enzymes. The effect of the herb in reducing the pathological lesions were also similar to the standard drug.
Conclusion: Crude leaf powder of the plant Adhatoda vasica could be used as a suitable herbal alternative to mitigate aflatoxicosis in broiler chicken.
Platelet Microparticles Influence Gene Expression and Modulate Biological Activities of Chronic Myeloid Leukemia Cells (K562)
Authors: Nikravesh Fariba , Khalilabadi Roohollah Mirzaee , Farsinejad Alireza , Valandani Hajar Mardani 
Published: August 2023

Abstract
Background
The current understanding emphasizes the intricate interplay between leukemia and its environment. Platelet microparticles play a crucial role in facilitating intercellular communication and contribute to the complex landscape of cancer pathology. This study aimed to investigate the influence of Platelet microparticles on cell proliferation, apoptosis, and the expression of key genes, including P53, P21, Cyclin D1, Bax, and Bcl-2, within the context of a Chronic Myeloid Leukemia cell line (K562).
Methods and Results
Platelet microparticles were obtained through centrifugation at various speeds, and their concentration was quantified using the BCA assay. To determine the size and immunophenotypic characteristics of the PMPs, both the DLS technique and flow cytometry were employed. Cell proliferation was assessed using the MTT assay, and cell cycle analysis was conducted through DNA content evaluation. Real-time PCR was utilized for gene expression analysis of Bax, Bcl-2, Cyclin D1, P53, and P21. Flow cytometry was employed to examine cell apoptosis. The findings revealed that platelet microparticles have the ability to decrease proliferation of the K562 cell line, while not exerting an impact on apoptosis and cell cycle progression. Analysis through real-time PCR indicated an upregulation in the gene expression of P53, P21, and Bcl-2, accompanied by a downregulation in Bax and Cyclin D1.
Conclusion
This investigation sheds light on the intricate relationship between CML and its microenvironment, particularly the involvement of platelet-derived microparticles. The study underscores the potential of PMPs to influence cell behavior and gene expression, providing a deeper understanding of their role in CML and its therapeutic implications.