bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of benzydamine hydrochloride on cumulative propofol consumption in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP): A randomized placebo-controlled trial
Authors: Mohapatra Partha Sarathi , Gaur Bhanu Pratap Singh , Nayak Laba Kumar , Das Mousumi , Nath Preetam 
Published: January 2025

The Endoscopic retrograde cholangiopancreatography (ERCP) procedure is utilized for diagnosis and treatment of various biliary and pancreatic disorders. A variety of different drugs with different doses have been used to provide sedation, although they are associated with distinctive pros and cons. Propofol is a widely used sedative agent due to its rapid onset and short duration of action, making it suitable for procedures like ERCP. However, its use is not devoid of risks, including respiratory depression and hypotension. Therefore, strategies to minimize propofol dosage are of clinical significance. After obtaining institutional ethics committee approval and CTRI registration study was conducted on 150 patients posted for ERCP procedure, with random allocation into two groups of 75 in each group. One group received interventional drug and other group received placebo 3 minutes before the procedure. Cumulative propofol consumption in terms of µg/kg/min and incidence of desaturation, hypotension as well as sore throat within 24 hours was recorded. The results of the study demonstrated that total propofol consumption was significantly lower in the benzydamine hydrochloride group compared to the placebo group, with values of 144.1 ± 27.3 µg/kg/min versus 154.5 ± 30.7 µg/kg/min (p = 0.03). The incidence of desaturation was marginally lower in the intervention group (1.3%) compared to the placebo group (2.7%), although this difference was not statistically significant (p = 0.56). Similarly, the occurrence of hypotension was 9.3% in the benzydamine hydrochloride group and 12% in the placebo group (p = 0.59). Postoperative sore throat within 24 hours was reported in 9.3% of patients in the intervention group and 13.3% in the placebo group, but this difference also did not reach statistical significance (p = 0.44).The study concluded that benzydamine hydrochloride gargles are effective in reducing the cumulative propofol requirement during ERCP procedures. This reduction may help minimize dose-related complications associated with propofol use.
Opioid sparing effect of ultrasound-guided continuous bilateral erector spinae plane block in cardiac surgery requiring sternotomy: A cross-sectional observational study
Authors: Kamath Manjunath R , Belgaumkar Alok Gopal , Harish B G  
Published: January 2025

The erector spinae plane (ESP) block is mostly used to relieve pain in people who have had breast surgery. The block is now being used in cardiac surgery. Because sternotomy discomfort is severe, individuals undergoing this require multimodal analgesia. The ESP block has recently become popular in cardiac anaesthesia, necessitating the study.To determine the efficacy of ESP block in reducing the opioid requirement for postoperative analgesia in cardiac surgeriesThe study enrolled 66 people who were having heart surgery between January-2020 to December-2021; that required a median sternotomy. The anaesthesiologist separated them into two groups: group-1 received intravenous morphine, while group-2 received ESP block. The subjects were secured with a catheter in the ESP using USG guidance after receiving general anaesthesia according to institutional practice. Following Surgery, group-2 received 0.25% levobupivacaine bolus of 10ml, followed by a 0.125% levobupivacaine infusion at a rate of 5ml/hour. The other group was given 0.1mg/kg body weight of morphine every six hours. Following extubation, the subjects were assessed for pain using the Prince Henry hospital pain scale at intervals of 0, 3, 6, 12, 24, 48 hours 12 participants in the group-2 had the pain score of 1/5, at 6th hour interval whereas only 5 participants in the group-1 had 1/5. Further at 48-hour interval 30 of the participants in study group had pain score of 0/5, and only 19 participants in the control group had the pain score of zero. ESP block group had more patients with a pain score of zero than morphine group at different time points i.e., 5 vs 0 at 6 h; 30 vs 19 at 48 h (P&#60;0.05). ESP block has significantly reduced the intravenous opioid consumption, and it has also proved to have better patient satisfaction
Efficacy of isobaric 1% chloroprocaine intrathecal for patients undergoing infraumbilical short surgical procedures
Authors: Gowda Anup Natha Ramachandra , Shivashankar Archana , Shetty Sarika M , Babu T Raghavendra , Kumar M R Anil , Marulasiddappa Meghana 
Published: January 2025

The selection of an ideal anesthetic agent for spinal anesthesia is critical in an ambulatory setting. While lignocaine is associated with transient neurological symptoms (TNS), bupivacaine has a prolonged duration of action. This study aimed to evaluate chloroprocaine for its potential benefits in early ambulation and discharge. To assess the time required for micturition, ambulation, sensory and motor block characteristics, and the time taken for 2-segment regression, as well as to document complications such as hypotension, bradycardia, nausea, and vomiting. Following Institutional Ethics Committee (IEC) approval, this observational study involved 100 ASA I and II patients undergoing surgeries under subarachnoid block. Informed consent was obtained from all participants. All patients received 30 mg of 1% chloroprocaine intrathecally while in a sitting position. The primary endpoints were the time taken for micturition and ambulation, while secondary endpoints included sensory and motor block characteristics, time taken for 2-segment regression, and incidence of complications. The average time for unassisted ambulation was 130 ± 12.57 minutes, while the time for micturition was 152.59 ± 13.57 minutes. The onset of sensory block was 8.36 ± 1.48 minutes, and motor onset occurred at 10.10 ± 1.2 minutes. The duration of sensory block was 100 ± 12.12 minutes, and motor block lasted 105.93 ± 14.01 minutes. No instances of bradycardia or hypotension were observed in any patient. Chloroprocaine (30 mg) provided faster recovery from anesthesia, demonstrating its suitability for short outpatient surgical procedures, particularly regarding ambulation and early discharge from the hospital.
A comparison of oral tramadol and oral tapentadol for prevention of perioperative shivering during subarachnoid block in patients undergoing transurethral resection of prostate: A randomized control trial
Authors: Jannu Vinayaka , Namratha M  , Hanagandi Meghana Prasad 
Published: January 2025

: Postanaesthetic shivering is a frequent complication after subarachnoid block, particularly in elderly patients, and can lead to discomfort and adverse effects. Prophylactic interventions are needed to mitigate this issue and enhance patient comfort during surgery.: This randomized controlled trial (RCT) aimed to compare the efficacy of oral tramadol and tapentadol as premedications for the prevention of perioperative shivering following subarachnoid block in geriatric patients undergoing transurethral resection of the prostate (TURP).: A total of 150 elderly patients scheduled for TURP under subarachnoid block were enrolled in the study. Patients were randomized into two groups: Group A (n=75) received 50 mg of oral tramadol, and Group B (n=75) received 50 mg of oral tapentadol 90 minutes before surgery. After achieving an adequate block, body temperature (forehead and tympanic membrane), shivering grades, sedation scores, and the incidence of nausea and vomiting were recorded at regular intervals throughout the perioperative period. Data were analyzed using ANOVA, Student's t-test, test of proportions, and Fisher’s exact test where appropriate. A p-value of &#60;0.05 was considered statistically significant.: There were no significant differences between the two groups in the incidence of shivering. Mean body temperature measurements (forehead and tympanic membrane) were comparable across both groups throughout the observation period. The sedation scores between Group A and Group B showed no statistically significant differences. Four patients in Group A experienced nausea, while no such incidents were reported in Group B.: Both oral tramadol and oral tapentadol are equally effective as premedications for the prevention of perioperative shivering following subarachnoid block in elderly patients. However, tapentadol may be associated with a lower incidence of nausea compared to tramadol.
Comparison of effect of perioperative infusion of lidocaine vs dexmedetomidine on post-operative pain in patients undergoing laparoscopic cholecystectomy
Authors: Parveen Shirin , Rizwan Anam , Kaur Harpreet , Yadav Kirtika , Singh Harshita , Sidhu Karanvir S 
Published: January 2025

Growing concerns regarding opioid-related side effects and complications have prompted alternative analgesic modalities for post-operative pain in laparoscopic cholecystectomy. This study aimed to compare the efficacy of Lidocaine and Dexmedetomidine infusions administered intraoperatively by evaluating post-operative VAS scores, hemodynamic parameters, recovery profiles, total number of rescue analgesics required, and any side effects of the study drugs between the two groups. Interventional, double-blind, randomized study on 66 ASA I/II class patients aged 18 to 60 years of both genders. These Patients were randomized to Group L (Lidocaine) and Group D (Dexmedetomidine). Hemodynamic Parameters were noted at pre-defined time frames intra/post-operatively. Post-operative Visual Analogue Scale Score and Richmond Agitation Sedation Score monitoring was done. : The study did not result in any significant hemodynamic event, indicating the safety of both Lidocaine and Dexmedetomidine. Moreover, both drugs were found to be effective in managing post-operative pain but mean VAS was found to be significantly lower in Group D as compared to that in Group L at 120 min follow-up only (p&#60;0.05). The recovery characteristics were also similar for most of the evaluation periods, further reinforcing the safety and effectiveness of these drugs. It can be inferred that perioperative infusion of both Lidocaine and Dexmedetomidine effectively delayed the post-operative rescue analgesic need, with similar recovery profiles. However, of the two, Dexmedetomidine had a slight edge over Lidocaine in terms of analgesic effect and recovery profile.
Comparison of high flow nasal cannula and conventional oxygen therapy post-extubation in intensive care unit: A prospective crossover observational study
Authors: Bhat Govindraj M , Shetty Anil R , Kintamani Gouri Pratyusha 
Published: January 2025

Post-extubation respiratory support is crucial for optimal recovery and preventing reintubation in intensive care unit (ICU) patients. High Flow Nasal Oxygen (HFNO) has emerged as an effective alternative to conventional oxygen therapy (COT) for maintaining oxygenation and improving patient outcomes after extubation. This study aimed to compare the effects of HFNO and conventional oxygen therapy on dyspnea scores, arterial blood gas (ABG) parameters, physiological variables such as respiratory rate (RR), heart rate (HR), blood pressure, and patient comfort. ICU patients who were mechanically ventilated, ready for extubation, and had successfully completed a Spontaneous Breathing Trial (SBT) were enrolled. Participants were divided into two groups: Group A received HFNO for the first 30 minutes after extubation, followed by a Venturi Mask (VM) for the next 30 minutes. Group B received a VM immediately after extubation, followed by HFNO. Dyspnea scores were assessed using a visual analogue scale, and HR, Mean Arterial Pressure (MAP), RR, Oxygen Saturation (SpO₂), and ABG parameters were recorded and compared between the two groups. Baseline hemodynamic parameters, intubation time, and comorbidities were similar between the groups (p = 0.325). Both groups showed a significant improvement in dyspnea scores with HFNO (Group A: from 34.6 to 16.4, Group B: from 33 to 19.1). HR, MAP, RR, and SpO₂ remained stable with both HFNO and VM, while HFNO slightly improved the Partial Pressure of Oxygen (from 154 to 177.3). Patient comfort was significantly higher with HFNO compared to VM (p = 0.003). HFNO is more effective in reducing dyspnea and improving patient comfort post-extubation compared to conventional oxygen therapy, without affecting vital signs such as heart rate and respiratory rate. This suggests that HFNO is a promising modality for post-extubation oxygenation in ICU patients.
Effect of music therapy in the perioperative anaesthesia requirement in patients undergoing laparascopic cholecystectomy
Authors: Saxena Kirti N , Mishra Devika , Saha Moushumi , Wadhwa Bharti 
Published: January 2025

Music can create conditioned relaxation and helps in reducing stress levels. In clinical practice, music therapy can be combined with pharmacological treatment modalities to achieve additive or synergistic effects and to minimize the side effects associated with polypharmacy.70 patients of American Society of Anaesthesiologists (ASA) classification I–II, age between 18 and 50 years with body mass index (BMI) ≤30 kg/m2 who underwent laparoscopic cholecystectomy under general anaesthesia were randomly assigned to two groups (n = 35): the music group (M) and the no-music group (NM). Intraoperative hemodynamic stability, occurrence of awareness, postoperative pain and anxiety level and patient satisfaction were evaluated and compared between two groups. The patients in the music therapy group had better awakening quality (3.76 ± 1.64 vs. 5.11 ± 2.13; p &#60; 0.001) and lower level of pain according to a VAS (visual analogue scale) (2.73 ± 1.28 vs. 3.61 ± 1.40; p &#60; 0.001), and higher patient satisfaction rates (73.3 vs. 36.6, p &#60; 0.001). Incidence of intraoperative awareness, and intraoperative hemodynamic parameters like HR (heart rate), SAP (systolic arterial pressure), DAP (diastolic arterial pressure) and MAP (mean arterial pressure) were lower but not statistically significant.Intraoperative music therapy can be an effective method to decrease perioperative pain, anxiety and incidence of intraoperative awareness with better intraoperative hemodynamic stability and less perioperative analgesic consumption. In addition, it also showed a positive effect on postoperative parameters and level of sedation.
Comparison of intermittent intravenous bolus of phenylephrine and noradrenaline in management of spinal anesthesia induced hypotension in elective cesarean section: A randomized controlled trial
Authors: Choudhury Arpita , Das Shalini , Roy Sankar , Hembrom Bani Parvati Magda , Bhattacharya Dipasri 
Published: January 2025

Though Noradrenaline infusion is showing promising results for management of spinal anaesthesia-induced hypotension, there are very few studies that evaluated intermittent intravenous (i.v) bolus dose of inj. Noradrenaline. So, we aimed to compare intermittent i.v. bolus of phenylephrine and noradrenaline in management of spinal anaesthesia-induced hypotension in elective LSCS.This randomized controlled study was conducted in obstetrics operation theatre from August 2022 to April 2023. Intermittent I.V. bolus dose of Phenylephrine (Group A) was compared with intermittent I.V. bolus dose of Noradrenaline (Group B). Data regarding baseline heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), hypotension, bradycardia, total number of bolus doses of study drugs required, intraoperative nausea and vomiting, neonatal Apgar score at one and 5minute, and umbilical cord blood gas analysis at birth were collected and analyzed using standard statistical tests.HR at 9 minute, 12 minutes, 15 minutes, and 20 minutes after spinal anaesthesia was significantly lower in group A than in group B. No statistically significant difference was found between the groups in terms of SBP, DBP, MAP, APGAR score at one and five minutes, UA pH, UA PO2, UA PCO2, UA HCO, UV pH, UV PO2, UV PCO2, UV HCO. Incidence of nausea and vomiting was higher in group A than in group B (P-value = 0.006).Thoughintermittent I.V. bolus of both Phenylephrine and Noradrenaline are equally efficacious in management of spinal anaesthesia-induced hypotension during elective LSCS, inj. Noradrenaline is a better option with fewer adverse effects.
Seroprevalence And Sociodemographic Characteristics of Hepatitis B Virus Infection Among Pregnant Women Attending Rural Hospital in Karu-Abuja, Nigeria
Authors: GARBA Dr Sunusi Rimi , Sunday AKU Dr Amwe , Ali UMARU Dr Abdulsalam , NANDANG Dr Nanman , Lafia BABA Dr Saadatu , Jeremiah UDEH Dr Ikechukwu , UMAR Aliyu Amina , Zubvushia ACHI Dr Richard , SHITTU Dr Farida Abdulkarim , Precious ANYAOGU Dr Chukwuemeka , Adedoyin ADESIDA Dr Adewumi , Okechukwu UGWU Dr Aloy , Funtua RABIU Dr Anas , Mbakwe Dr Marcus , OMISAKIN Dr Sunday Isaac , Nantim Sunday Dr SHEDUM , Junaidu Dr ABDULKARIM , Nansuk Kansel Dr NANKAT 
Published: January 2025

Background: Hepatitis B virus (HBV) infection in pregnancy is associated with direct effect of pregnancy and potential viral transmission from mother to newborn. The data on hepatitis B virus infection among pregnant women in the rural area of Karu are very scarce. It is associated with a serious burden on the health care system and the economy of the family. This study therefore aimed to determine the seroprevalence of hepatitis b virus infection among pregnant women attending rural hospital in Karu-Abuja, Nigeria from 1st January 2021 to 31st December 2021
Study design: This was a retrospective cross-sectional study carried out among pregnant women that booked for antenatal care at Nigeria Customs Hospital Karu Abuja over a one-year period.
Materials and Method: Cases were identified from records in labour ward, and antenatal clinic, from November 1st, 2023, to October 31st, 2024. Data was entered and analyzed using the IBM Statistical Product and Service Solutions (SPSS Statistics) Version 27. Armonk, NY: IBM CorpA
Results: A total of 906 pregnant women were registered for antenatal care during the study period of which 79 cases were diagnosed with hepatitis B virus infection and only 74 has the complete information and were included in the statistical analysis. The retrieval rate was 93.6% and the prevalence of hepatitis B virus infection among the study participants was 8.7%. The mean age of the study participants were 31.459 ± 4.4635 years, The mean gestational age at the diagnosis was 23.86 (4.73) weeks. Majority of the participants were multigravida and had attended tertiary levels of education and were booked. About 44 (59.2) participants had received Hepatis vaccine.
Conclusion: The prevalence rate of hepatitis B sero-positivity among pregnant women attending the antenatal clinic was higher more than the national target of 8.0 and majority of participants were unvaccinated for HBV.
Effect of Silicon and Abscisic Acid Spray on Growth, Yield and Quality of Sunflower under Different Irrigation Periods
Authors: Ahmed Firas W. , AL-Tameemi Ali Jasim Hadi 
Published: January 2025

Background: During autumn season of 2022, a field experiment was conducted at College of Agricultural Engineering Sciences, University of Baghdad to investigate the effect of silicon and abscisic acid spraying on sunflowers under various water stress conditions on growth, yield and quality of sunflower in Calcareous Soil. Methods: The experiment involved three levels of water stress, with irrigation scheduled every 2, 4 and 6 days. Additionally, three concentrations of silicon 0, 2 and 4 mg L-1 and three concentrations of abscisic acid 0, 0.5, 1 mg L-1 was considered. The experimental design employed a randomized complete block design (RCBD) with a split-split plot arrangement with three replicates. Result: Results showed a significant effect of irrigation every 2 days exhibited superior performance, leading to peroxidase activity achieved 15.8 mg protein-1, catalase activity of 10.98 mg protein-1, abscisic acid concentration of 0.462 µg ml-1, silicon concentrations of 0.283%. The application of 4 mg L-1 of silicon proved to be superior, resulting in peroxidase activity of 20.35 mg protein-1, catalase activity of 18.58 mg protein-1, abscisic acid concentration of 0.473 µg ml-1, proline concentration of 12.46 µM g-1, silicon concentrations of 0.246 % and seed yield of 6.064 Mg ha-1. The use of 1 mg L-1 of abscisic acid achieved superiority, yielding peroxidase activity of 20.12 mg protein-1, catalase activity of 19.05 mg protein-1, abscisic acid of 0.508 µg ml-1, proline concentration of 14 µM g-1, silicon at 0.271 % and seed yield of 6.136 Mg ha-1 .
Effect of Organic Manures on Soybean [Glycine max (L.) Merrill] Performance and Soil Properties in Northeast of India, Nagaland
Authors: Sruthi Bingimalla , Singh A.K. , Ao Merasenla , Gadi Yabi 
Published: January 2025

Background: In 2022, a study was conducted at Nagaland University, Medziphema, to examine the impact of various organic nutrient sources on soybean growth, yield and soil properties during the kharif season. Methods: The experiment utilized a completely randomized design with nine treatments, including a control group and aimed to evaluate the performance of the MACS 1460 soybean variety. The experiment included treatments such as farmyard manure (FYM) at different rates, vermicompost, poultry manure and pig manure, applied at varying quantities. Result: Application of poultry manure at 3 t ha-1 demonstrated superior performance in terms of plant growth, yield and soil nutrient content, making it the optimal nutrient management practice for enhancing soybean productivity and soil properties in this specific context. Additionally, poultry manure at this rate significantly improved protein and oil content in the soybean.