bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging evaluation of para-aortic lymph nodes in cervical cancer
Authors: Zhu Minying , Zhuo Qingchan , Liu Wenci , Guan Chengnong , Zuo Yufang 
Published: June 2023

Background In recent years, much literature has reported the diagnostic value of computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET)-CT in para-aortic lymph node metastasis of cervical cancer. Purpose To compare and analyze the para-aortic lymph node presentations found in cervical cancer on different images in order to determine the best precise imaging method for identifying metastatic lymph nodes. Material and Methods PubMed, Web of Science, MEDLINE, and other databases were searched for the non-invasive detection of metastatic lymph nodes for a comprehensive comparison. Results Positive lymph nodes on CT are significantly related to the following factors: short axis ≥10 mm; and round or central necrosis. Positive lymph nodes on MRI are significantly related to the following factors: short axis ≥8 mm; inhomogeneous signal intensity; morphology: round, irregular edge, extracapsular invasion, central necrosis, loss of lymph node structure, burrs, or lobes; and ADC value decreases, combined with local actuality. On PET-CT examination, when the short axis of the lymph node is >5 mm, the SUV is >2.5, or the FDG uptake is greater than that of the surrounding tissue, it is a metastatic lymph node. Conclusion In conclusion, different imaging techniques show metastatic lymph nodes in different ways. Combining the patient's medical history with the symptoms of the aforementioned lymph nodes, together with one or more imaging techniques, is important to diagnose para-aortic lymph nodes in cervical cancer.
Navigating the river: Experiences of women academic leaders in Vietnam
Authors: Phuong Jane , Rowe Pia , Lawless Ann 
Published: June 2023

Gender inequities in leadership positions in academia persist globally. However, there are significant variations depending on country contexts, and devising strategies to overcome these will require a thorough understanding of the country-specific barriers. While the underrepresentation of women in senior leadership positions has become a burgeoning field of inquiry in recent years, few studies have been conducted to investigate this problem in Vietnam. This qualitative research uses photo elicitation interviews and interpretative phenomenological analysis (IPA) to bridge this gap. It examines six Vietnamese women’s lived experiences as academic leaders and argues that by analysing the metaphors they use, we can extend our understanding of the issues academic women face. In Vietnam, the metaphor of a river that constantly changes represents the careers of women in academia. The study highlights the need to equalise and progressively introduce developmental opportunities to set Vietnamese women up for success in academic leadership. JEL Classification: i2i23
Use of Cardioprotective Antidiabetic Medications in Adults With and Without Cardiovascular Disease, 2015 to March 2020
Authors: Sherrill Christina H. , Hwang Andrew Y. 
Published: June 2023

Background: Certain glucagon-like peptide-1 receptor (GLP-1) agonists and sodium-glucose cotransporter-2 inhibitors (SGLT2-inhibitors) can reduce cardiovascular risk in individuals with type 2 diabetes and cardiovascular disease (CVD). However, these medications can be expensive, potentially limiting their use. Objectives: The primary objective was to characterize the use of cardioprotective GLP-1 agonists and SGLT2-inhibitors among adults with diabetes with and without CVD. The secondary objective was to investigate the association of socioeconomic factors and health care utilization with the use of these medications. Methods: Adults aged ≥20 years old with self-reported diabetes, A1c ≥6.5%, or fasting glucose ≥126 mg/dL were identified using the 2015 to March 2020 National Health and Nutrition Examination Survey. The primary outcome was the use of cardioprotective GLP-1 agonists or SGLT2-inhibitors compared in individuals with and without CVD. Secondary analyses included identification of socioeconomic factors and health care utilization associated with the use of cardioprotective antidiabetic medications, stratified by CVD status. Weighted analyses were conducted to account for the complex survey design. Results: Use of cardioprotective antidiabetic medications was higher in adults with CVD compared to those without CVD (7.8% vs. 4.6%, P = 0.02), which was driven by the use of cardioprotective SGLT2-inhibitors (4.6% versus 1.9%, P = 0.002). Lower income level and less frequent health care visits within the past year were associated with lower likelihood of using these medications. Conclusion and Relevance: Despite preferential use in individuals with diabetes and CVD, the prevalence of cardioprotective antidiabetic medication use remains relatively low. Disparities in use appear to exist based on income level and health care utilization.
LncRNA NEAT1 Promotes Vascular Endothelial Cell Dysfunction via miR-218-5p/GAB2 and Serves as a Diagnostic Biomarker for Deep Vein Thrombosis
Authors: Wang Shuping , Wang Fei , Ren Juan , Yang Hongyu 
Published: June 2023

Objective Deep vein thrombosis (DVT) is a common peripheral disease. This study aimed to elucidate the diagnostic biomarker of lncRNA nuclear-enriched abundant transcript 1 (NEAT1) in the DVT, and explore possible mechanisms in Human umbilical vein endothelial cells (HUVECs). Methods 101 patients with lower extremity DVT and 82 healthy controls were enrolled. RT-qPCR was designed to resolve the mRNA levels of NEAT1, miR-218-5p, and GAB2. ROC was applied for the diagnosis of DVT. Systemic inflammation (IL-1β, IL-6, and TNF-α) and adhesion factor (SELP, VCAM-1, and ICAM-1) were examined by the ELISA. And cell proliferation, migration, and apoptosis were conducted by the CCK-8, Transwell, flow cytometry assay. The targeting relationship was validated by Dual luciferase reporter and RIP analysis. Results NEAT1 and GAB2 were upregulated in patients with DVT, while miR-218-5p was decreased ( P < .01). Serum NEAT1 can identify DVT patients from healthy individuals. NEAT1 was positively correalted with fibrinolysis factors, coagulation factors, and vasoconstrictors. NEAT1 inhibited the proliferation, migration, and promoted apoptosis as well as inflammation and adhesion factors secretion of HUVECs ( P < .05), but all were impaired by overexpression of miR-218-5p ( P < .05). NEAT1 promoted GAB2 expression in DVT by acting as a sponge for miR-218-5p. Conclusion Elevated NEAT1 is a possible DVT diagnostic biomarker, and is implicated in vascular endothelial cell dysfunction via miR-218-5p/GAB2 axis.
Unusual stroke-like symptoms with oxaliplatin use
Authors: Soliman Abram , Habibi Shaghayegh , Dasanu Constantin A. 
Published: June 2023

Introduction Oxaliplatin has become the mainstay of treatment for many cancers, but its use can be accompanied by unusual side effects. Case report We describe herein a 74-year-old patient with pancreatic cancer who developed severe motor weakness affecting lower extremities after starting treatment with oxaliplatin on three separate occasions. Our patient also experienced slurred speech, with decreased ability to phonate and word-finding difficulty. Brain imaging studies did not suggest recent brain ischemia, and the symptoms resolved within 15–20 h. Management and outcome Oxaliplatin had to be discontinued due to suboptimal tolerance and a short-lived clinical response. After discontinuation of oxaliplatin, she did not experience any more similar symptoms. A score of 9 on the Naranjo nomogram supported a definite causality relationship between oxaliplatin and the observed neurologic toxicity. Discussion Rare reports of stroke-like events have previously been described with oxaliplatin. While the exact mechanism of these phenomena is not known, alterations in neuronal sodium channels might be involved. Clinicians, pharmacists, and patients need to be aware of these rare but important side effects of oxaliplatin. Nonetheless, work-up for a cerebrovascular accident is still warranted as hypercoagulability related to malignancy can also predispose the patients to strokes.
Measures to ensure safety during telerehabilitation of people with stroke: A scoping review
Authors: Gutierrez-Arias Ruvistay , González-Mondaca Camila , Marinkovic-Riffo Vinka , Ortiz-Puebla Marietta , Paillán-Reyes Fernanda , Seron Pamela 
Published: June 2023

Background Measures used to prevent adverse events during the implementation of exercise sessions delivered via telerehabilitation can be varied, ranging from simple telephone monitoring to synchronous therapist-led sessions. However, this information is scattered in the literature, as evidence synthesis studies have only addressed the safety, satisfaction, and effectiveness aspects of exercise delivered via telerehabilitation. Aims This scoping review aims to describe that measures are used to ensure safety during exercise sessions delivered to people with stroke through telerehabilitation, as reported by authors of primary studies. Secondarily, it describes the designs most frequently used to notify the effects of telerehabilitation and evidence level, the characteristics of the participants and type of stroke, and the characteristics of telerehabilitation. Summary of review A scoping review was conducted according to the Joana Briggs Institute (JBI) recommendations. A systematic search of MEDLINE (Ovid), Embase (Ovid), CENTRAL, and CINHAL was conducted from inception to August 2022, and a review of systematic review references on the topic. We included primary studies that enrolled adults with stroke who underwent exercise delivered via telerehabilitation. Two independent reviewers performed study selection and data extraction, and disagreements were resolved by consensus or a third reviewer. A qualitative analysis of the information was performed. One hundred seven primary studies (3991 participants) published between 2002 and 2022 were included. Most studies were case series (43%) and rated with an Oxford level of evidence of “4” (55.3%). Regarding randomized clinical trials, half included 53 or more participants (IQR 26.75 to 81). Most studies applied the exercises via asynchronous telerehabilitation (55.1%), of which only ten reported measures to avoid adverse events. Some of the measures included assessing the location where exercises are to be performed, only using a seated position, and using live warning systems that prevent or stop exercises when they are risky. Conclusions Reporting of measures implemented to prevent adverse events during exercise delivery via asynchronous telerehabilitation is scarce. Future primary studies should always consider reporting adverse events related to exercise delivery via telerehabilitation and strategies implemented to decrease the incidence of these unwanted safety events. Registration number INPLASY202290104.
Language and technological inclusion among immigrant low-income Latina mothers: A feminist action research intervention
Authors: Cedeño Diana 
Published: June 2023

Summary Although Latinx families comprise the largest growing population in the United States, research has not examined how the lack of social inclusion (e.g., multidimensional term comprising economic, political, and cultural dimensions, among others) influences the lives of low-income Latina mothers. Social inclusion, which is a term born as a counterpart to social exclusion, has been overlooked as an alternative construct that allows the development of personal agency. Contrary to social exclusion paradigms which often focus on deficits, social inclusion focuses on recognizing inherit strengths among vulnerable families. The first purpose of this research is to explore social inclusion (a strength perspective) as a much-needed alternative to social exclusion (deficit view). The second is to describe the experiences of low social inclusion among low-income urban Latina mothers via two interviews, a focus group, recollection of artifacts from participants, and reflective journaling, which were documented within a context of a feminist action research intervention. Participants consisted of 12 low-income Latina mothers ( N  =  12) who participated in a financial literacy intervention. Findings Via thematic analysis, findings confirmed two new dimensions of low social inclusion not found in traditional literature: low language and technological inclusion. Applications Recommendations for social work practitioners and future research include developing culturally relevant interventions among minoritized communities and families, for instance, by promoting bilingual curricula and implementing technology in current interventions, which can have significant positive effects on the social inclusion of vulnerable communities.
Liquid embolic agents for middle meningeal artery embolization in chronic subdural hematoma: Institutional experience with systematic review and meta-analysis
Authors: Sioutas Georgios S , Vivanco-Suarez Juan , Shekhtman Oleg , Matache Irina-Mihaela , Salem Mohamed M , Burkhardt Jan-Karl , Srinivasan Visish M , Jankowitz Brian T 
Published: June 2023

Introduction Chronic subdural hematoma (CSDH) is associated with high recurrence rates. Middle meningeal artery embolization (MMAE) has emerged as a promising treatment option. In this systematic review and meta-analysis, we aimed to assess the safety and efficacy of MMAE for CSDH using liquid embolic agents and compare them with particles. Methods We systematically reviewed all studies describing MMAE for CSDH with liquid embolic agents, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Additionally, we included a cohort of patients from our institution using liquid and particle embolic agents. Data were analyzed using random-effects proportions and comparisons meta-analysis, and statistical heterogeneity was assessed. Results A total of 18 studies with 507 cases of MMAE with liquid embolic agents (including our institutional experience) were included in the analysis. The success rate was 99% (95% confidence interval [CI]: 98–⁠100%), all complications rate was 1% (95% CI: 0–⁠5%), major complications rate was 0% (95% CI: 0–⁠0%), and mortality rate was 1% (95% CI: 0–⁠6%). The rate of hematoma size reduction was 97% (95% CI: 73–⁠100%), complete resolution 64% (95% CI: 33–⁠87%), radiographic recurrence 3% (95% CI: 1–⁠7%), and reoperation 3% (95% CI: 1–⁠7%). No significant differences in outcomes were found between liquid and particle embolic agents. Sensitivity analyses revealed that liquid embolic agents were associated with lower reoperation rates in upfront MMAE (risk ratio 0.13, 95% CI: 0.02–⁠0.95). Conclusion MMAE with liquid embolic agents is safe and effective for the treatment of CSDH. Outcomes are comparable to particles, but liquids were associated with a decreased risk of reoperation in upfront MMAE. However, further studies are needed to support our findings.
To Separate or to Include: A Qualitative Study of Placement Decisions for Students With Special Education Needs in China
Authors: Deng (邓猛) Meng , Ma (马滢) Ying , Xie (谢正立) Zhengli 
Published: June 2023

Purpose This study aimed to explore the perspectives of students with special education needs (SEN) and of relevant stakeholders on how they make decisions when choosing educational placements. Design/Approach/Methods Eight students with SEN (four with intellectual disabilities and four with physical disabilities) who had transferred between special and regular education schools and their stakeholders, including parents, school principals, classroom teachers, and students without SEN, participated in the interviews. Findings Findings revealed that students with SEN were torn between the two forms of conflict placement. Different educational placements implied different educational methods and effects, and educational effects contributed to placement choices in return. Placement decisions largely relied on SEN students’ abilities, stakeholders’ attitudes, and school policies, with SEN students’ abilities being the most dominant factor, implying a model based on personal ability instead of rights and support. Originality/Value The Chinese government should formulate and implement policies to bring about more systematic changes in the education system and ensure adequate resources and professional support for students with SEN.
Immune profiling after allogeneic hematopoietic cell transplantation in pediatric acute myeloid leukemia
Authors: Shahid Sanam , Ceglia Nicholas , Le Luduec Jean-Benoît , McPherson Andrew , Spitzer Barbara , Kontopoulos Theodota , Bojilova Viktoria , Panjwani M. Kazim , Roshal Mikhail , Shah Sohrab P. , Abdel-Wahab Omar , Greenbaum Benjamin , Hsu Katharine C. 
Published: June 2023

Abstract
Although allogeneic hematopoietic cell transplant (allo-HCT) is curative for high-risk pediatric acute myeloid leukemia (AML), disease relapse remains the primary cause of posttransplant mortality. To identify pressures imposed by allo-HCT on AML cells that escape the graft-versus-leukemia effect, we evaluated immune signatures at diagnosis and posttransplant relapse in bone marrow samples from 4 pediatric patients using a multimodal single-cell proteogenomic approach. Downregulation of major histocompatibility complex class II expression was most profound in progenitor-like blasts and accompanied by correlative changes in transcriptional regulation. Dysfunction of activated natural killer cells and CD8+ T-cell subsets at relapse was evidenced by the loss of response to interferon gamma, tumor necrosis factor α signaling via NF-κB, and interleukin-2/STAT5 signaling. Clonotype analysis of posttransplant relapse samples revealed an expansion of dysfunctional T cells and enrichment of T-regulatory and T-helper cells. Using novel computational methods, our results illustrate a diverse immune-related transcriptional signature in posttransplant relapses not previously reported in pediatric AML.
Multicenter phase 2 study of romidepsin plus lenalidomide for previously untreated peripheral T-cell lymphoma
Authors: Ruan Jia , Zain Jasmine , Palmer Brett , Jovanovic Borko , Mi Xinlei , Swaroop Alok , Winter Jane N. , Gordon Leo I. , Karmali Reem , Moreira Jonathan , Petrich Adam M. , Pro Barbara 
Published: June 2023

Abstract
Peripheral T-cell lymphomas (PTCLs) are associated with poor prognosis when treated with cytotoxic chemotherapy. We report the findings of a phase 2 study evaluating a chemotherapy-free combination of romidepsin plus lenalidomide as initial treatment for patients with PTCL who were aged &gt;60 years or noncandidates for chemotherapy. Treatment was initiated with romidepsin 10 mg/m2 IV on days 1, 8, and 15 and lenalidomide 25 mg taken orally from days 1 to 21 of 28-day cycle for up to 1 year. The primary objective was overall response rate (ORR). Secondary objectives included safety and survival. The study enrolled 29 patients with a median age of 75 years, including 16 (55%) angioimmunoblastic T-cell lymphoma (AITL), 10 (34%) PTCL– not otherwise specified, 2 ATLL, and 1 EATL. Grade 3 to 4 hematologic toxicities included neutropenia (45%), thrombocytopenia (34%), and anemia (28%). Grade 3 to 4 nonhematologic toxicities included hyponatremia (45%), hypertension (38%), hypoalbuminemia (24%), fatigue (17%), hyperglycemia (14%), hypokalemia (14%), dehydration (10%), and infection (10%). At median follow-up of 15.7 months, 23 patients were evaluable and received a median treatment of 6 cycles. The ORR was 65.2% with complete response (CR) at 26.1%, including 78.6% ORR and 35.7% CR for AITL. Median duration of response was 10.7 months, with 27.1 months for patients achieving CR. The estimated 2-year progression-free survival was 31.5%, and 2-year overall survival was 49.5%. This study provides the first demonstration that the biologic combination of romidepsin and lenalidomide is feasible and effective as initial therapy for PTCL and warrants further evaluation. This trial was registered at www.clinicaltrials.gov as #NCT02232516.
PRMT5 inhibition drives therapeutic vulnerability to combination treatment with BCL-2 inhibition in mantle cell lymphoma
Authors: Brown-Burke Fiona , Hwang Inah , Sloan Shelby , Hinterschied Claire , Helmig-Mason JoBeth , Long Mackenzie , Chan Wing Keung , Prouty Alexander , Chung Ji-Hyun , Zhang Yang , Singh Satishkumar , Youssef Youssef , Bhagwat Neha , Chen Zhengming , Chen-Kiang Selina , Di Liberto Maurizio , Elemento Olivier , Sehgal Lalit , Alinari Lapo , Vaddi Kris , Scherle Peggy , Lapalombella Rosa , Paik Jihye , Baiocchi Robert A. 
Published: June 2023

Abstract
Mantle cell lymphoma (MCL) is an incurable B-cell malignancy that comprises up to 6% of non-Hodgkin lymphomas diagnosed annually and is associated with a poor prognosis. The average overall survival of patients with MCL is 5 years, and for most patients who progress on targeted agents, survival remains at a dismal 3 to 8 months. There is a major unmet need to identify new therapeutic approaches that are well tolerated to improve treatment outcomes and quality of life. The protein arginine methyltransferase 5 (PRMT5) enzyme is overexpressed in MCL and promotes growth and survival. Inhibition of PRMT5 drives antitumor activity in MCL cell lines and preclinical murine models. PRMT5 inhibition reduced the activity of prosurvival AKT signaling, which led to the nuclear translocation of FOXO1 and modulation of its transcriptional activity. Chromatin immunoprecipitation and sequencing identified multiple proapoptotic BCL-2 family members as FOXO1-bound genomic loci. We identified BAX as a direct transcriptional target of FOXO1 and demonstrated its critical role in the synergy observed between the selective PRMT5 inhibitor, PRT382, and the BCL-2 inhibitor, venetoclax. Single-agent and combination treatments were performed in 9 MCL lines. Loewe synergy scores showed significant levels of synergy in most MCL lines tested. Preclinical, in vivo evaluation of this strategy in multiple MCL models showed therapeutic synergy with combination venetoclax/PRT382 treatment with an increased survival advantage in 2 patient-derived xenograft models (P ≤ .0001, P ≤ .0001). Our results provide mechanistic rationale for the combination of PRMT5 inhibition and venetoclax to treat patients with MCL.