bluuebunny/crossref_metadata_2025_split huggingface dataset:
CycLing and EducATion (CLEAT): protocol for a single centre randomised controlled trial of a cycling and education intervention versus standard physiotherapy care for the treatment of Hip Osteoarthritis
Authors: Wainwright Thomas W , Parkinson Erika P , Immins Tikki , Docherty Sharon , Goodwin Elizabeth , Hawton Annie , Low Matthew , Samways Joanna , Rees Tim , Saunders Geoff , Middleton Robert G 
Published: April 2023

AbstractBackgroundOsteoarthritis (OA) is a chronic degenerative joint disorder for which there is no known cure. Non-surgical management for people with mild-to-moderate hip OA focuses mainly on alleviating pain and maximising function via the National Institute for Health and Care Excellence (NICE) recommended combination of education and advice, exercise, and, where appropriate, weight loss. The CHAIN (Cycling against Hip pAIN) intervention is a group cycling and education intervention conceived as a way of implementing the NICE guidance.MethodsCycLing andEducATion (CLEAT) is a pragmatic, two parallel arm, randomised controlled trial comparing CHAIN with standard physiotherapy care for the treatment of mild-to-moderate hip OA. We will recruit 256 participants referred to the local NHS physiotherapy department over a 24-month recruitment period. Participants diagnosed with hip OA according to NICE guidance and meeting the criteria for GP exercise referral will be eligible to participate. Primary outcome is the difference in HipDisability and Osteoarthritis Outcome Score (HOOS)function, daily living subscale between those receiving CHAIN and standard physiotherapy care. Secondary outcomes include performance-based functional measures (40m walking, 30s chair stand and stair climb tests), ability for patient to self-care (patient activation measure) and self-reported health-related resource use including primary and secondary care contacts. The primary economic endpoint is the number of quality adjusted life years (QALYs) at 24 weeks follow-up. The study is funded by the National Institute for Health Research, Research for Patient Benefit PB-PG-0816-20033.DiscussionThe literature identifies a lack of high-quality trials which inform on the content and design of education and exercise in the treatment of patients with hip OA and explore cost-effectiveness. CLEAT is a pragmatic trial which seeks to build further evidence of the clinical benefits of the CHAIN intervention compared to standard physiotherapy care within a randomised, controlled trial setting, and examine its cost-effectiveness.Trial registration numberISRCTN19778222. Protocol v4.1, 24th October 2022
TIGAR promotes malignant proliferation of NSCLC by modulating deoxynucleotide anabolism via a YBX1-RRM2B axis
Authors: fang Jie , Liu Ben , Hao Shuai , Wu Jun-Chao , Li Bin , Lan Qing , Xu Guoqiang , Miao Chao-yu , Qin Zheng-Hong 
Published: April 2023

Abstract
Background:Lung cancer is one of the most common causes of cancer-related death worldwide due to its rapid growth and metastasis. TIGAR plays a role in promoting survival in various cancer cells, but the molecular mechanisms on metabolic reprogram in tumor cells are not fully understood.
Methods: TIGAR expression was detected in lung cancer by western blot and immunohistochemistry. A shRNA interference system was used to knockdown the TIGAR in NSCLC cell lines to delineate its role in NSCLC tumor proliferation using in vitro functional assays and in vivo mouse models. Finally, transcriptomics and metabolomics were used to identify the mechanism of TIGAR.
Results: The expression of TIGAR in tumor tissues of NSCLC patients was significantly higher than that of adjacent tissues, which was associated with poor prognosis of NSCLC. The proliferation of NSCLC cells in vitro and the growth of xenografted tumors in vivo were significantly inhibited by TIGAR knockdown. With a combination of transcriptomics and metabolomics, we found that TIGAR maintained intracellular deoxyribonucleotide levels by regulating the expression of the ribonucleotide reductase (RNR) subunit RRM2B, a protein involved in deoxynucleotide synthesis. Further studies with LC-MS and co-immunoprecipitation revealed that TIGAR interacted with the transcription factor YBX1, participated in its phosphorylation and nuclear translocation to induce the expression of its downstream gene RRM2B. In addition, overexpression of RRM2B or exogenous supplementation of dNTPs effectively rescued the restriction of cell proliferation and DNA repair caused by TIGAR knockdown.
Conclusion: The present studies revealed a novel mechanism of TIGAR in promoting the proliferation and DNA repair of NSCLC cells through maintaining the intracellular deoxynucleotide level via the YBX1-RRM2B axis.
Risk Factors for Postoperative Disseminated Intravascular Coagulation in Surgical Patients with Non-occlusive Mesenteric Ischemia
Authors: Kobayashi Toshimichi , Hidaka Eiji , Ando Akitoshi , Koganezawa Itsuki , Nakagawa Masashi , Yokozuka Kei , Ochiai Shigeto , Gunji Takahiro , Sano Toru , Tomita Koichi , Tabuchi Satoshi , Chiba Naokazu , Kawachi Shigeyuki 
Published: April 2023

Abstract
Purpose The prognostic impact of disseminated intravascular coagulation (DIC) in surgical patients with non-occlusive mesenteric ischemia (NOMI) is unclear. This study aimed to confirm the association between postoperative DIC and prognosis and to identify preoperative risk factors associated with postoperative DIC.Methods This retrospective study included 52 patients who underwent emergency surgery for NOMI between January 2012 and March 2022. Kaplan–Meier curve analysis with the log-rank test was used to compare 30-day survival and hospital survival between patients with and without postoperative DIC. In addition, univariate and multivariate logistic regression analyses were performed to identify the preoperative risk factors for postoperative DIC.Results The 30-day and hospital mortality rates were 30.8% and 36.5%, respectively, and the incidence rate of DIC was 51.9%. Compared to patients without DIC, patients with DIC showed significantly lower rates of 30-day survival (41.5% vs 96%, log-rank P < 0.001) and hospital survival (30.2% vs 86.4%, log-rank, P < 0.001). Logistic regression analyses showed that the Japanese Association for Acute Medicine (JAAM) DIC score (OR = 2.697; 95% CI, 1.408–5.169; P = 0.003) and Sequential Organ Failure Assessment (SOFA) score (OR = 1.511; 95% CI, 1.111–2.055; P = 0.009) were independent risk factors for postoperative DIC in surgical patients with NOMI.Conclusion The development of postoperative DIC is a significant prognostic factor for 30-day and hospital mortality in surgical patients with NOMI. In addition, the JAAM DIC score and SOFA score have a high discriminative ability for predicting the development of postoperative DIC.
Performance of Endobronchial Ultrasound Transbronchial Needle Aspiration as the First Nodal Staging Procedure for the Determination of Programmed Death Ligand-1 Expression in Non-Small Cell Lung Cancer Patients
Authors: Polanco Dinora , Pinilla Lucía , Gracia-Lavedan Esther , Gatius Sonia , Zuil María , Pardina Marina , Gómez Silvia , Barbé Ferrán 
Published: April 2023

Abstract
Purpose The determination of the Programmed Death Ligand-1 (PD-L1) expression is part of the diagnostic algorithm for advanced non-small-cell lung cancer (NSCLC) patients. We aimed to analyze the diagnostic performance of EBUS-TBNA performed as first-choice nodal staging procedure for the determination of PD-L1 expression in NSCLC patients.Methods Longitudinal-prospective study including NSCLC patients diagnosed between January 2018 and October 2019, for whom a primary tumor biopsy sample and an EBUS-TBNA cytological malignant sample were available. Samples with fewer than 100 malignant cells were considered inadequate. PDL-1 IHC 22C3 pharmDx antibody was used. The percentage of tumor cells expressing PD-L1, setting 1% and 50% as cutoff points, was collected. The weighted kappa coefficient was used to assess the concordance of PD-L1 expression. The PD-L1 expression was compared precision terms.Results From a total of 43 patients, 53 pairs of samples were obtained, of which 23 (43.4%) were adequate and included for analysis. The weighted kappa coefficient for PD-L1 expression was 0.41 (95% CI: 0.15–0.68) and 0.56 (95% CI: 0.23–0.9) for cutoff values ≥ 1% and ≥ 50%, respectively. In advanced stages, the weighted kappa coefficient was 0.6 (95% CI: 0.3–0.9) and 1 (95% CI: 1–1) for PD-L1 expression cutoff values ≥ 1% and ≥ 50%, respectively. EBUS-TBNA showed a sensitivity, specificity, positive predictive value, and negative predictive value of 1 to detect PDL-1 expression ≥ 50% in advanced stages.Conclusion EBUS-TBNA performed as first nodal staging procedure provides reliable specimens for the detection of PD-L1 expression ≥ 50% in advanced NSCLC patients and could guide immunotherapy.
Falls and falls-related injuries in individuals with chronic ankle symptoms: A cross-sectional study
Authors: Smith Michelle , Mahrouqi Munira Al , MacDonald David , Vicenzino Bill 
Published: April 2023

Abstract
Background Falls are major public concern globally. While falls are associated with osteoarthritis and persistent pain at the hip and knee, falls have not been investigated in people with chronic ankle symptoms. This cross-sectional survey aimed to compare self-reported history of falls between adults with and without chronic ankle symptoms. Secondary aims were to compare concern about falling and balance confidence between groups, and to identify factors associated with falling.Methods 226 participants (134 participants with chronic ankle pain and/or stiffness and 92 controls) participated in this cross-sectional case-control study. Participants completed an online survey about falls in the past 12 months, injuries and hospitalisation associated with falling, concern about falling, balance confidence, function, pain and comorbidities.Results 86 (64%) participants with chronic ankle symptoms and 24 (26%) controls reported at least one fall in the last 12 months (p < 0.001). Participants with chronic ankle symptoms reported more falls, more injurious falls, and more hospitalisations because of a fall than controls (p > 0.002). There was a small effect for lower balance confidence and higher concern about falling in symptomatic participants (standardised mean difference: 0.39–0.49; p > 0.017). Multiple linear regression analysis identified that falling was associated with concern about falling (p = 0.001) and the presence of ankle symptoms (p = 0.01).Conclusions Falls and falls-related injuries are a problem in individuals with chronic ankle symptoms. The high falls occurrence and concern about falling in individuals with chronic ankle symptoms suggest the need for clinicians to assess these factors in this population.
Environmental, Social, and Governance (ESG) and Artificial Intelligence in Finance: State-of-the-Art and Research Takeaways
Authors: LIM Tristan 
Published: April 2023

Abstract

The rapidly growing research landscape in finance, encompassing environmental, social, and governance (ESG) topics and associated Artificial Intelligence (AI) applications, presents challenges for both new researchers and seasoned practitioners. This study aims to systematically map the research area, identify knowledge gaps, and examine potential research areas for researchers and practitioners. The investigation centers around three research questions: key research themes for ESG and AI in finance, research intensity and interest evolution, and the use and progression of AI techniques within these themes. Eight archetypical research domains were identified: (i) Trading and Investment, (ii) ESG Disclosure, Measurement and Governance, (iii) Firm Governance, (iv) Financial Markets and Instruments, (v) Risk Management, (vi) Forecasting and Valuation, (vii) Data, and (viii) Responsible Use of AI. Distinctive AI techniques were found to be employed across these archetypes. The study contributes to consolidating knowledge on the intersection of ESG, AI, and finance, offering an ontological inquiry and key takeaways for practitioners and researchers. Important insights include the popularity and crowding of the Trading and Investment domain, the growth potential of the Data archetype, and the high potential of Responsible Use of AI, despite its low publication count. By understanding the nuances of different research archetypes, researchers and practitioners can better navigate this complex landscape and contribute to a more sustainable and responsible financial sector.
Particulate Matters (PM2.5, PM10) and the risk of depression: analysis of the Korean Longitudinal Study of Aging (KLoSA), 2016-2020 in South Korea
Authors: Park Hyunkyung , Kim Ho , Lee Whanhee , Song Insung , Kwon Dohoon , Oh Jieun , Moon Jeongmin , Park Jinah , Min Jieun , Kim Ejin , Jang Hyemin , Kang Cinoo 
Published: April 2023

Abstract
Background
There is a growing concern that particulate matter (PM) such as PM2.5 and PM10 has contributed to exacerbating psychological disorders, particularly depression. However, little is known about the roles of these air pollutants on depression in elderly. Therefore, this study aimed to examine the association between PM2.5 and PM10, and depression in the elderly population in South Korea.
Methods
We used panel survey data, the Korean Longitudinal Study of Aging (KLoSA), administered by the Labor Institute during the study period of 2016, 2018, and 2020 covering 217 districts in South Korea (n = 7674). Annual district-specific PM2.5 and PM10 concentrations were calculated for the study period from the monthly prediction concentrations produced by a machine-learning-based ensemble model (cross-validated R2: 0.87), then linked to the people matching with year and their residential district. We constructed a generalized estimating equation (GEE) model with a logit link to identify the associations between each of the long-term PM2.5 and PM10 exposures and depression (CES-D 10) after adjusting for individual and regional factors as confounders.
Results
In single-pollutant models, we found that long-term 10 μg/m3 increments in PM2.5 (OR 2.83, 95% CI 2.18–3.67) and PM10 (OR 2.36, 95% CI 1.99–2.79) were associated with an increased risk of depression in the elderly. Associations were consistent after adjusting for other air pollutants (NO2, O3, and CO) in two-pollutant models. In addition, the impacts substantially differed by regions grouped by the tertile of the population density, for which the risks of particulate matters on depression were substantial in the middle- or high-density population regions in contrast to the low-density population regions.
Conclusions
Long-term exposure to PM2.5 and PM10 was associated with a higher risk of developing depression in elderly people. The impact was modified by the population density level of the region where they reside.
Maintaining long-term physical activity after cancer: A conceptual framework to inform intervention development
Authors: Grimmett Chloe , Corbett Teresa , Bradbury Katherine , Morton Kate , May Carl R , Pinto Bernardine M , Foster Claire 
Published: April 2023

Abstract
Purpose: This paper describes a conceptual framework of maintenance of physical activity and its application to future intervention design.
Methods: Evidence from systematic literature reviews and in-depth (N=27) qualitative interviews with individuals with cancer were used to develop a conceptual framework of long-term physical activity behaviour. Determinants of long-term PA were listed and linked with domains of the Theoretical Domains Framework which in turn were linked to associated behaviour change techniques (BCTs) and finally to proposed mechanisms of action (MoA).
Results: The conceptual framework is presented within the context of non-modifiable contextual factors (such as demographic and material resources) and in the presence of learnt and adapted behavioural determinants of skills, competence and autonomous motivation that must be established as part of the initiation of physical activity behaviour. An inventory of 8 determinants of engagement in long-term PA after cancer was developed. Clusters of BCTs are presented along with proposed MoA which can be tested using mediation analysis in future trials.
Conclusion: Understanding the processes of PA maintenance after cancer and presentation of implementable and testable intervention components and mechanisms of action to promote continued PA can inform future intervention development.
Implications for cancer survivors. This resource can act as a starting point for selection of intervention components for those developing future interventions. This will facilitate effective support of individuals affected by cancer to maintain PA for the long term.
Molecular identification of Opisthorchis viverrini among the northeastern Cambodian population by internal transcribed spacer 2 (ITS2)- based polymerase chain reaction (PCR)
Authors: Rattanapitoon Schawanya , La Nav , Boonsuya Alisa , Thanchonnang Chutharat , Arunsan Patpicha , Pechdee Phornphitcha , Leng Monica , Rattanapitoon Nathkapach 
Published: April 2023

Abstract

The southeast Asian fluke Opisthorchis viverrini remains endemic, particularly in Thailand, Lao PDR, Cambodia, Vietnam, and Myanmar. However, there is a lack of data on the prevalence of liver fluke infection in Kratie Province in northeastern Cambodia. The present study aimed to detect O. viverrini DNA in fecal specimens using polymerase chain reaction (PCR) based on the internal transcribed spacer 2 (ITS2) region of ribosomal DNA (rDNA). The prevalence and percentage of O. viverrini infection were described by data analysis. The associated prevalence of O. viverrini infection was examined by bivariate binary logistic regression analyses. The total number of fecal specimens (n = 377) used for identifying food-borne trematodes was 6.89% of O. viverrini DNA-positive cases. Moreover, most O. viverrini infections were found in males (3.71%), those < 20 years (3.44%), those at primary school level (2.91%), farmers (3.18%), and the Trapaing Srae village (4.24%) in Snuol district, Kratie Province. O. viverrini infection was associated with age < 20 years (ORcru=0.569, 95% CI = 0.388–0.836, p = 0.004, ORadj=0.604, 95% CI = 0.412–0.885, p = 0.010). This study demonstrates that O. viverrini infection is distributed in rural areas located near freshwater reservoirs. Therefore, active surveillance, clinical examination of related hepatobiliary and cholangiocarcinoma, and health education are needed.
PRAME induces genomic instability in uveal melanoma
Authors: Harbour J. William , Kurtenbach Stefan , Sanchez Margaret , Kuznetsoff Jeffim , Rodriguez Daniel , Weich Natalia , Dollar James , Cruz Anthony , Kurtenbach Sarah , Field Matthew , Decatur Christina , Sorouri Mahsa , Lai Fan , Shiekhattar Ramin , Pelaez Daniel , Correa Zelia , Verdun Ramiro 
Published: April 2023

Abstract
PRAME is a CUL2 ubiquitin ligase subunit that is normally expressed in the testis but becomes aberrantly overexpressed in many cancer types in association with aneuploidy and metastasis. Here, we show that PRAME is expressed predominantly in spermatogonia around the time of meiotic crossing-over in coordination with genes mediating DNA double strand break repair. Expression of PRAME in somatic cells upregulates pathways involved in meiosis, chromosome segregation and DNA repair, and it leads to increased DNA double strand breaks, telomere dysfunction and aneuploidy in neoplastic and non-neoplastic cells. This effect is mediated at least in part by ubiquitination of SMC1A and altered cohesin function. PRAME expression renders cells susceptible to inhibition of PARP1/2, suggesting increased dependence on alternative base excision repair pathways. These findings reveal a distinct oncogenic function of PRAME than can be targeted therapeutically in cancer.
Database study of risk factors for breast cancer-related lymphedema: statistical analysis of 2359 cases in 10 years
Authors: Matsumoto Akihiro , Ushio Kai , Kimura Hiroaki , Tomioka Shinichi , Sasada Shinsuke , Mikami Yukio 
Published: April 2023

Abstract
Background
Identification of risk factors is important for the prevention of Breast Cancer-Related Lymphedema (BCRL), and epidemiological large-scale studies are needed. Although database studies are suitable for large-scale surveys, there have been no studies using databases to investigate risk factors for BCRL. The purpose of this study was to test the hypothesis that database-based studies are useful in identifying risk factors for BCRL.
Methods
Patients diagnosed with breast cancer during a 10-year period from April 2009 to March 2020 were selected from the medical database of Hiroshima University Hospital. As a retrospective observational study, risk factors for BCRL were validated by logistic regression analysis (p < 0.05).
Results
A total of 4471 breast cancer patients were selected and 2359 met study criteria; the incidence of BCRL was 4.8%. Risk factors for BCRL ultimately identified by multivariate logistic regression analysis were obesity with BMI 25 to 30 (OR = 3.066, 95%CI: 1.408 ~ 6.677), severe obesity with BMI > 30 (OR = 5.791, 95%CI: 2.239 ~ 14.97), surgical axillary lymph node dissection (OR = 3.212, 95%CI: 1 .918 ~ 5.378), chemotherapy with docetaxel (OR = 1.795, 95%CI: 1.062 ~ 3.032), and conventional radiation to the breast or chest wall with lymph nodes in the irradiated area (OR = 3.299, 95%CI: 1.842 ~ 5.910).
Conclusions
The risk factors for BCRL identified in this study were generally similar to those in previous studies, indicating that database-based studies are useful for identifying risk factors for BCRL. A multicenter study involving a larger number of patients and study items needs to be conducted in order to more fully elucidate the risk factors for BCRL.
Nuevos viejos tiempos: aportes a la cronología de El Churcal (Valle Calchaquí central, Salta)
Authors: Sprovieri Marina , Barbich Santiago 
Published: April 2023

Nuestro objetivo es evaluar la cronología del poblado conglomerado de El Churcal (valle Calchaquí, Salta), a partir de nuevos fechados radiocarbónicos realizados sobre muestras provenientes de excavaciones estratigráficas recientes. Para ello, además, se han recalibrado y contextualizado dos dataciones previas del sitio y considerado datos existentes sobre la cronología de otros asentamientos de la región y del Noroeste argentino. Sobre la base de la nueva información radiocarbónica podemos sostener que la ocupación de El Churcal alcanzó fechas más tardías que la originalmente planteada, algunas de las cuales se superponen a los límites temporales planteados actualmente para los primeros momentos de la presencia inka en el área. Esto nos sugiere la posibilidad de que El Churcal se encontrara ocupado al inicio de dicho proceso, lo que resulta significativo para reflexionar sobre el rol de los grandes poblados conglomerados en el proceso de ocupación regional más tardío y de avance inkaico.