bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review and Meta-Analysis of the Association Between Psychopathology and Social Functioning in Schizophrenia
Authors: Handest Rasmus , Molstrom Ida-Marie , Gram Henriksen Mads , Hjorthøj Carsten , Nordgaard Julie 
Published: June 2023

Abstract

Background
Impaired social functioning is a major, but under-elucidated area of schizophrenia. It’s typically understood as consequential to, eg, negative symptoms, but meta-analyses on the subject have not examined psychopathology in a broader perspective and there’s severe heterogeneity in outcome measures. To enhance functional recovery from schizophrenia, a more comprehensive understanding of the nature of social functioning in schizophrenia is needed.

Study Design
In this systematic review and meta-analysis, we searched PubMed, PsycInfo, and Ovid Embase for studies providing an association between psychopathology and social functioning. Meta-analyses of the regression and correlation coefficients were performed to explore associations between social functioning and psychopathology, as well as associations between their subdomains.

Study Results
Thirty-six studies with a total of 4742 patients were included. Overall social functioning was associated with overall psychopathology (95% CI [−0.63; −0.37]), positive symptoms (95% CI [−0.39; −0.25]), negative symptoms (95% CI [−0.61; -0.42]), disorganized symptoms (95% CI [−0.54; −0.14]), depressive symptoms (95% CI [−0.33; −0.11]), and general psychopathology (95% CI [−0.60; −0.43]). There was significant heterogeneity in the results, with I2 ranging from 52% to 92%.

Conclusions
This is the first systematic review and meta-analysis to comprehensively examine associations between psychopathology and social functioning. The finding that all psychopathological subdomains seem to correlate with social functioning challenges the view that impaired social functioning in schizophrenia is mainly a result of negative symptoms. In line with classical psychopathological literature on schizophrenia, it may be more appropriate to consider impaired social functioning as a manifestation of the disorder itself.
The Family Life of Peter and Ruth Townsend: Social Science and Methods in 1950s and Early 1960s Britain
Authors: Renwick Chris 
Published: June 2023

Abstract
Peter Townsend (1928–2009) was one of the most important British social scientists of the twentieth century, best known for pioneering and innovative research on poverty, as well as his political campaigning, most notably for the Child Poverty Action Group. This article returns to Townsend’s influential work on ageing, for which he first became widely known, during the 1950s and early 1960s. It does so to recover the ways in which his research, first in Bethnal Green at the Institute of Community Studies (ICS), and then at the London School of Economics, as well as the professional and political networks he built during this period, were rooted in and shaped by his home life in Hampstead. As will be shown, the most important figure in the interconnecting spheres of Townsend’s career was his wife, Ruth (1927–2011), who not only was central to the construction of a way of life in which the boundaries between research, the domestic sphere, and politics were often so blurred as to be non-existent, but also made significant and underappreciated contributions to her husband’s research.
Imagining Economic Growth in Post-War Britain
Authors: Tomlinson Jim 
Published: June 2023

Abstract
This article contends that common representations of the history of the British economy and economic policy in the ‘Golden Age’ period (circa 1950–73) as a story of ‘failure’ rely overwhelmingly on one measure, that of Gross Domestic Product (GDP) growth. Drawing on the foundational criticisms of this metric made by Simon Kuznets, it is argued that, for this period of British economic history, shortfalls in measured GDP growth in comparison with other rich countries are a very poor measure of changes in economic well-being in the UK. If we follow this argument and discard the belief that one metric can summarize trends in such well-being, the notion of ‘failure’ in this period should be set aside in favour of a more nuanced, multidimensional assessment.
Interaction of mercury species with proteins: towards possible mechanism of mercurial toxicology
Authors: Rupa Sharmin Akther , Patwary Md Abdul Majed , Matin Mohammed Mahbubul , Ghann William Emmanuel , Uddin Jamal , Kazi Mohsin 
Published: May 2023

AbstractThe nature of the binding of mercurials (organic and inorganic) and their subsequent transformations in biological systems is a matter of great debate as several different hypotheses have been proposed and none of them has been conclusively proven to explain the characteristics of Hg binding with the proteins. Thus, the chemical nature of Hg-protein binding through the possible transportation mechanism in living tissues is critically reviewed herein. Emphasis is given to the process of transportation, and binding of Hg species with selenol-containing biomolecules that are appealing for toxicological studies as well as the advancement of environmental and biological research.
Patients and Parents’ Satisfaction and Self-Reported Evaluation After Single-Event Multilevel Surgery in Cerebral Palsy
Authors: Morais Filho Mauro César de , Fujino Marcelo H. , Kawamura Cátia M. , Lopes José Augusto F. , Benavides Daniela M. , Muzaurieta Aurelio A. 
Published: May 2023

Purpose:
The aim of this study was to analyze the results of single-event multilevel surgery (SEMLS) in cerebral palsy (CP) based on objective gait outcomes and self-reported evaluations.

Methods:
In total, 258 patients with spastic diplegic CP, GMFCS I-III, who underwent SEMLS and with preoperative and postoperative gait analyses, were included in the SEMLS group (SG). The same database was used to compose the control group (CG) formed of 88 subjects who had performed at least 2 gait analyses and did not undergo surgical intervention between tests. Demographic data, Gait Deviation Index (GDI), and a self-reported questionnaire were analyzed, and results were compared between groups.

Results:
The GDI decreased from 59.6 to 57.9 in the CG and increased from 51.3 to 58.4 in the SG (P<0.001). There was no change in patients’ walking ability in the CG. The number of patients who walk community distances increased after SEMLS in the group that had a GDI improvement >5 points (from 12.3% to 24.7%, P=0.008) and in patients GMFCS I and II (from 9.2% to 20.4%, P=0.028). According to patient and parental responses on satisfaction, the most significant improvements were reported in self-esteem, mobility, body image, and independence. In total, 51.1% of the patients were extremely satisfied or satisfied, while 3.9% were unsatisfied or extremely unsatisfied with the treatment results. Of the parents surveyed, 60.1% were extremely satisfied or satisfied, whereas just 5.0% were unsatisfied or extremely unsatisfied.

Conclusions:
In the studied group, an improvement in outdoor walking for community distances after SEMLS, as reported in questionnaires, was observed only when GDI increase was >5 points and in GMFCS I and II.

Level of Evidence:
Level III.
An Update on Pediatric Acute Hematogenous Osteomyelitis in New Zealand - A Decade on
Authors: McDonald Anna C.E. , Julian Jack , Voss Lesley M. , Boyle Matthew J. , Crawford Haemish A. 
Published: May 2023

Introduction:
New Zealand (NZ) has high rates of pediatric acute hematogenous osteomyelitis (AHO) with males and children of Pasifika and Māori ethnicity overrepresented.

Aims:
To update the incidence of Pediatric AHO over 10 years, identifying trends in presentation, organisms, treatment, and outcomes.

Methods:
A 10-year retrospective review of children aged 6 weeks to 15 years admitted with Pediatric AHO across two centers from 2008 to 2017. Demographic data, features of presentation, investigations, management, and complications were collected. Incidence was calculated from census data. Data were compared with our osteomyelitis database from the previous decade.(1)

Results:
796 cases were identified. The incidence was 18 per 100,000 per annum. The average age was 7.7 years. Pasifika and Māori children are overrepresented (57%). 370 children (51%) came from low socioeconomic areas. Methicillin-sensitive Staphylococcus aureus was the most common pathogen (87%). Methicillin-resistant Staphylococcus aureus (MRSA) rates are low (4.4%). Forty-four (5.5%) children were admitted to the Pediatric Intensive Care Unit (PICU) with 9% mortality. The mean duration of antibiotics was 40 days. 325 children (41%) had surgery. Chronic infection has increased from 1.7% to 5.7%.

Conclusions:
NZ has high rates of AHO, however, the incidence has decreased from the previous decade. Males, those in low socioeconomic areas, Pasifika and Māori have high disease burden. The use of MRI as a diagnostic modality has increased. Future studies should focus on improving treatment via prospective analysis and reporting long-term morbidity to improve outcomes for children with severe disease and reduce rates of chronic infection.
Trauma systems in Italy: the Lombardy experience
Authors: Cioffi Stefano Piero Bernardo , Cimbanassi Stefania , Sammartano Fabrizio , Chiara Osvaldo 
Published: June 2023

Abstract
The epidemiology of major trauma in Italy reflects the current European trend. Most injuries come from road crash, domestic, and workplace accidents. During recent decades, the improvement of trauma systems led to a dramatic reduction of preventable deaths. This article describes the history, development, and current organization of the Lombardy trauma system, which has been one of the first to be developed in Italy.
COVID-19 and cardiovascular complications: updates of emergency medicine
Authors: Zhao Jianli , Xie Yaoli , Meng Zhijun , Liu Caihong , Wu Yalin , Zhao Fujie , Ma Xinliang , Christopher Theodore A. , Lopez Bernard J. , Wang Yajing 
Published: June 2023

Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV-2 variants, has become a global pandemic resulting in significant morbidity and mortality. Severe cases of COVID-19 are characterized by hypoxemia, hyperinflammation, cytokine storm in lung. Clinical studies have reported an association between COVID-19 and cardiovascular disease (CVD). Patients with CVD tend to develop severe symptoms and mortality if contracted COVID-19 with further elevations of cardiac injury biomarkers. Furthermore, COVID-19 itself can induce and promoted CVD development, including myocarditis, arrhythmia, acute coronary syndrome, cardiogenic shock, and venous thromboembolism. Although the direct etiology of SARS-CoV-2–induced cardiac injury remains unknown and underinvestigated, it is suspected that it is related to myocarditis, cytokine-mediated injury, microvascular injury, and stress-related cardiomyopathy. Despite vaccinations having provided the most effective approach to reducing mortality overall, an adapted treatment paradigm and regular monitoring of cardiac injury biomarkers is critical for improving outcomes in vulnerable populations at risk for severe COVID-19. In this review, we focus on the latest progress in clinic and research on the cardiovascular complications of COVID-19 and provide a perspective of treating cardiac complications deriving from COVID-19 in emergency medicine.
Mouse nerve growth factor suppresses neuronal apoptosis in valproic acid-induced autism spectrum disorder rats by regulating the phosphoinositide-3-kinase/serine/threonine kinase signaling pathway
Authors: Jian Jie , Li Li-Guo , Zhao Peng-Ju , Zheng Rui-Juan , Dong Xian-Wen , Zhao Yong-Hong , Yin Bao-Qi , Li Sheng , Cheng Hui , Li Hong-Lei , Li En-Yao 
Published: June 2023

Background
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by deficits in social communication and restrictive behaviors. Mouse nerve growth factor (mNGF), a neurotrophic factor, is critical for neuronal growth and survival, and the mNGF treatment is considered a promising therapy for neurodegeneration. In light of this, we aimed to evaluate the effect of mNGF on neurological function in ASD.

Methods
An ASD rat model was established by intraperitoneal injection of valproic acid (VPA). Social behavior, learning, and memory of the rats were measured. TdT-mediated dUTP Nick-end labeling and Nissl assays were performed to detect neuronal apoptosis and survival in the hippocampus and prefrontal cortex. Apoptosis-related proteins and oxidative stress markers were detected.

Results
mNGF improved locomotor activity, exploratory behavior, social interaction, and spatial learning and memory in VPA-induced ASD rats. In the hippocampus and prefrontal cortex, mNGF suppressed neuronal apoptosis, increased the number of neurons, superoxide dismutase, and glutathione levels, and decreased reactive oxygen species, nitric oxide, TNF-α, and IL-1β levels compared with the VPA group. In addition, mNGF increased the levels of Bcl-2, p-phosphoinositide-3-kinase (PI3K), and p-serine/threonine kinase (Akt), and decreased the levels of Bax and cleaved caspase-3, while the PI3K inhibitor LY294002 reversed these effects.

Conclusion
These data suggest that mNGF suppressed neuronal apoptosis and ameliorated the abnormal behaviors in VPA-induced ASD rats, in part, by activating the PI3K/Akt signaling pathway.
Obesity and fertility: a literature review of the association between parental obesity at the time of conception and embryo quality
Authors: Fufezan Maria Louise , Mocanu Edgar V. 
Published: June 2023

Obesity [body mass index (BMI) ≥30 kg/m2] has been shown to be a risk factor in reducing the rate of successful in vitro fertilization (IVF) outcomes. In this systematized literature review, we investigate whether embryo quality specifically is affected by single-parent obesity (maternal or paternal) and obesity in both parents at the time of conception. We systematically searched for studies published over the last 10 years that graded embryo quality in conventional IVF and intracytoplasmic sperm injection procedures. Studies that did not use measured weight and height for BMI calculation were excluded. Ten eligible articles were found across 13 public databases. Comparing the results of 1845 couples, both female and male obesity independently caused faster preimplantation embryo development (P <0.05). The fertilization rate was not affected by either female, male, or combined parental obesity (P>0.05). Day 3 embryo quality does not seem to be affected by either female or male obesity alone. The 2 studies that investigated the effect of combined parental obesity on embryo quality reached contradictory findings. Male, but not female, >7% BMI reduction following bariatric surgery significantly increased the number of top-quality embryos compared with their results before surgery (P<0.05). We conclude that embryos of couples with single-parent obesity are not of lower quality compared with those of normal-weight parents. Combined parental obesity may affect embryo quality. BMI reduction could lead toward a successful outcome in obese infertile couples, regardless of whether they are undergoing IVF or not.
How to measure arterial stiffness independently of blood pressure: the QKD method
Authors: Gosse Philippe , Boulestreau Romain , Doublet Julien , Laurent Stephane , Cremer Antoine 
Published: June 2023

Objective:
Arterial stiffness, an important predictor of cardiovascular event, has two components: one linked to the nonlinear elastic behaviour of the arterial wall and dependent of the blood pressure (BP) at the time of measurement, and the other linked to the structural modifications of the arterial wall as the consequences of the long-term effects of all cardiovascular risk factors, including BP. This second component is certainly the most important one and can be assessed with 24-h ambulatory monitoring of cardio-arm pulse transmission time (QKD method).

Methods:
The working hypothesis of this study is that QKD100-60, the value of the QKD for a 100 mmHg SBP and 60 bpm heart rate is independent of 24-h SBP in both normotensive volunteers and treated hypertensive patients, in whom the long-term influence of BP is limited, whereas QKD100-60 is not independent of 24-h SBP in untreated hypertensive patients in whom high BP was able to damage the arterial wall on the long term. So we studied the relationships of QKD100-60 with 24-h BP and heart rate together with age, sex, height in multivariate regression analysis in three groups of patients; normal, untreated and treated hypertensive patients. QKD was measured with Novacor devices.

Results:
In the normal population (n = 323, aged 29 ± 10 years) and in the treated hypertensive population (n = 425, aged 58 ± 13 years) the QKD100-60 was indeed not significantly related to 24-h SBP. In the untreated hypertensive population (n = 614, aged 51 ± 13 years) the QKD100-60 was weakly but significantly related to 24-h SBP (r = 0.249, P < 0.0001).

Conclusion:
Ambulatory monitoring of QKD provides indices of arterial stiffness independent of BP level at the time of measurement and most interestingly of 24-h BP with the potential to refine risk in patients with low traditional risk scores.
Role of descemet's stripping without keratoplasty in management of endothelial disease
Authors: Northey Luke C. , Moloney Gregory 
Published: May 2023

Purpose of review
To summarize recent literature on Descemet's stripping only (DSO) in management of endothelial disease with particular focus on Fuchs endothelial corneal dystrophy (FECD).

Recent findings
DSO is currently indicated in patients with early FECD, central guttae, and preserved peripheral corneal endothelial cell (CEC) count. Time to corneal clearance may be accelerated and maintained with addition of topical rho-kinase inhibitor (ROCKi). There are reports describing successful use of DSO to treat endothelial disease due to iatrogenic trauma. In patients with transcription factor 4 gene mutation, increased cytosine, thymine, guanine (CTG) triplet repeat load may be associated with DSO failure risk. Emerging pharmacotherapies and cell-suspension treatments may improve procedure effectiveness and expand clinical indications.

Summary
DSO can be used as the initial surgical treatment in management of symptomatic endothelial disease due to FECD where peripheral CEC function appears preserved. Stand-alone DSO or DSO combined with cataract surgery is effective and postoperative topical ROCKi supplementation will improve time to corneal clearance and CEC count.
RAND/UCLA Modified Delphi Panel on the Severity, Testing, and Medical Management of PIK3CA-Related Spectrum Disorders (PROS)
Authors: Broder Michael S , Adams Denise M , Canaud Guillame , Collins Christy , Davis Kristen , Frieden Ilona J. , Gibbs Sarah N , Hammill Adrienne M , Keppler-Noreuil Kim M , Nakano Taizo A , Penington Anthony , Srivastava Siddharth , Tollefson Megha M , Warman Matthew L 
Published: May 2023

Objective(s):
PIK3CA-related overgrowth spectrum (PROS) is a group of disorders caused by somatic variants in the PIK3CA gene. We aimed to update recommendations on the severity classification, testing, and medical management of patients with PROS.

Methods:
Using validated consensus methodology, we convened a 13-member panel in 2020 and reviewed current evidence on how to diagnose and treat PROS. The panel was asked to rate the level of disease severity, and the appropriateness of whether to test for a mutation and medical therapy in 217 patient scenarios before a virtual meeting. Panelists discussed areas of disagreement and completed ratings following the meeting.

Results:
The panel developed clinical presentations and endorsed the disease severity framework defined by functional impairment, a reduction in quality of life, and risk of death. Panelists agreed it is appropriate to test for a PIK3CA gene variant in every moderately/severely affected patient. Panelists agreed it may be appropriate to consider an mammalian (mechanistic) target of rapamycin inhibitor in some severely affected patients and some moderately affected patients with progressive disease. Although clinical trials have only recently begun and the evidence remains limited, panelists also agreed it may be appropriate to consider treatment with phosphoinositide 3-kinase/serine/threonine protein kinase inhibitors in severely affected patients with a confirmed PIK3CA variant or without a confirmed variant but with progressive disease.

Conclusion:
These recommendations represent the consensus of experts informed by published literature and experience. Future research should validate this guidance using clinical data. Once validated, we hope these recommendations will improve outcomes for patients with PROS.
Medications for opioid use disorder: An interactive educational program developed for the nurse practitioner curriculum
Authors: Culp-Roche Amanda , Vaughn Jacqueline , Arms Tamatha , Roberto Anka , Hubbell Sara , Link Tamara 
Published: June 2023

ABSTRACT
Opioid overdose deaths remain a major public health concern in the United States and led to the recent changes in regulations that allow nurse practitioners (NPs) to prescribe buprenorphine without the previously required Drug Addiction Treatment Act waiver. Previously, waiver requirements included 24 hours of opioid use disorder (OUD) and medications for OUD (MOUD) training. Although this training is no longer required, NPs need education related to providing nonstigmatizing care to individuals with OUD and safe MOUD prescribing practices. A combination of online didactic modules, in-person simulation activities, and experiential learning was provided to psychiatric mental health NP (PMHNP) and family NP (FNP) students enrolled in a Doctor of Nursing Practice (DNP) program. OUD was presented through a chronic care lens to normalize treatment and decrease stigma, and harm reduction principles were included to increase safe prescribing of MOUD. Fifty-six students completed the didactic training, 51 students participated in the simulation, and 11 students completed shadowing experiences with an experienced MOUD provider. Psychiatric mental health NP and FNP graduates of this DNP program have the knowledge and skills to provide MOUD to individuals struggling with OUD, thus potentially increasing access to care and decreasing overdose deaths.
Haemophilic arthropathy: basic protocols for clinical examination and imaging
Authors: Querol F. , Querol-Giner F. , Aguilar M. , Bonanad S. , Marqués E. , Blasco JM. , Pérez-Alenda S. 
Published: May 2023

In haemophilia, screening protocols in the prevention and treatment of common lesions still require unification of criteria. Patients with haemophilia seek medical consultation exclusively for two reasons: because they have requested an appointment for a routine check-up (1−2 times a year in case of severe haemophilia) or because they have developed acute bleeding that requires treatment.
The purpose of this paper is to emphasize the importance of an early differential diagnosis of joint damage and to review the techniques that allow an effective evaluation.
The World Federation of Haemophilia recommends the ‘Primary Prophylaxis’ treatment modality, and today, severe haemophilia patients adhering to that factor VIII/IX therapy have significantly reduced common injuries: haematomas, haemarthrosis, synovitis, and haemophilic arthropathy. The basic protocols and minimum data for the control of musculoskeletal health are described.
In summary, the primary goal of the haematologist-led multidisciplinary care team treating patients with haemophilia is likely to restore and/or preserve joint and musculoskeletal health, which is essential to promoting quality of life. Appropriate factor replacement regimens are required to prevent bleeding, these should be combined with physical activity and a physiotherapy program, in accordance with the recommendations of the World Health Organization for the general population.