bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nurses quietly quit their job more often than other healthcare workers: an alarming issue for healthcare services
Authors: Galanis Petros , Katsiroumpa Aglaia , Vraka Irene , Siskou Olga , Konstantakopoulou Olympia , Katsoulas Theodoros , Moisoglou Ioannis , Gallos Parisis , Kaitelidou Daphne 
Published: June 2023

Abstract
Background: Quiet-quitting phenomenon in not new but has been frequently discussed during the COVID-19 pandemic. Interestingly, the level of quiet quitting among healthcare workers (HCWs) has not been measured yet.
Objective: To assess the level of quiet quitting among HCWs, and identify possible differences between nurses, physicians, and other HCWs. Moreover, we investigated the impact of socio-demographic variables, job burnout, and job satisfaction on quiet quitting levels.
Methods: We conducted a cross-sectional study with a convenience sample of HCWs during June 2023. HCWs included nurses, physicians, dentists, pharmacists, midwives, psychologists, and physiotherapists that have been working in healthcare services. We measured socio-demographic characteristics of HCWs, job burnout with “Copenhagen Burnout Inventory”, job satisfaction with “Job Satisfaction Survey”, and quiet quitting with “Quiet Quitting” Scale.
Results: Study population included 1760 HCWs with a mean age of 41.1 years. Among our sample, 57.9% were quiet quitters, while 42.1% were non quiet quitters. In particular, 67.4% of nurses were quiet quitters, while prevalence of quiet quitting for physicians and other HCWs were 53.8% and 40.3% respectively (p<0.001). Multivariable linear regression analysis identified that the levels of quiet quitting were higher among nurses than physicians and other HCWs. Moreover, greater job burnout contributed more to quiet quitting, while less satisfaction implied more quiet quitting. Shift HCWs, and those working in private sector experienced higher levels of quiet quitting. Additionally, we found a negative relationship between clinical experience and quiet quitting.
Conclusions: More than half of our HCWs were described as quit quitters. Levels of quiet quitting were higher among nurses even when controlling for several confounders. Higher levels of job burnout and lower levels of job satisfaction were associated with higher levels of quiet quitting.
Does Tafel Analysis Make Sense for Water Oxidation at Metal Oxide/Oxyhydroxide Electrocatalysts?
Authors: Leng Wenhua 
Published: June 2023

Abstract
The oxygen evolution reaction (OER) has a vital role in many alternative-energy systems because it provides the protons and electrons required for converting electricity into chemical fuels1. Metal oxides and oxyhydroxides shows state-of-the-art activity for the OER, and their reaction kinetics and mechanism are generally analyzed by phenomenological Tafel equation (applied overpotential vs. log (current density), η-log⁡(i)) and power law rate equation2 (current density vs. oxidative charge density, i ∝Qn, where n is reaction order relative to charge density). Here it is demonstrated that none of them is utterly appropriate and that the current density equals the oxidative charge density exponential dependent rate constant multiplying the oxidative charge density. It is striking found that Tafel equation is just an approximation of novel rate law that can fully describe the i-η relationship and give rise to contrast physical meanings of both Tafel slope and intercept to the traditional. In addition, the established rate law explains why the phenomenological Butler-Volmer theory (out-sphere theory), which focuses on electron transfer, can apply to analysis the OER rates (inner-sphere theory) under a certain circumstances. These findings may thus lead to key insights both for strategies to predict and/or enhance electrocatalytic performances and for understanding OER mechanism at atom/molecular level.
Conformational compaction as a mechanism for ATP resolubilization of protein condensates
Authors: Gong Zhou , Zhu Yueling , Lin Shiyan , Meng Ling-Shen , Sun Min , Liu Maili , Li Jingyuan , Tang Chun 
Published: June 2023

Abstract
ATP has been shown to regulate the phase separation behavior of intrinsically disordered proteins (IDPs), but a detailed mechanism remains to be fully established. Using the RG/RGG-rich motif from the HNRNPG protein as our model system, we show that the condensation of the IDP follows a biphasic relationship with the concentration of ATP. At a relatively low ATP concentration, ATP dynamically interacts with the protein and neutralizes surface charges, which promotes intermolecular interactions and favors phase separation. At the same time, ATP binding makes the protein more compact while enhancing local dynamics. As the ATP concentration increases, further compaction of the IDP hinders intermolecular interactions, and consequently prevents the protein from phase separation. We have thus identified IDP conformational compaction a mechanism for the ATP regulation of phase separation.
Glycemia control using remote technologies
Authors: Suplotova L. A. , Alieva O. O. 
Published: June 2023

Diabetes mellitus is a chronic metabolic disease with a rapidly increasing prevalence. Glycemic control in diabetes mellitus remains the key to improving the effectiveness of therapy, reducing the risk of hypoglycemia, preventing microvascular complications, and reducing the long-term risk of macrovascular complications. However, regular glycemic control is only a part of this process, since an equally important step is the timely and correct interpretation of the data obtained, as well as the decision on further therapeutic tactics. Technological advances are providing tools to help diabetic patients reach their glycemic targets and facilitate ongoing monitoring of blood glucose levels. Currently, there is the possibility of remote monitoring of glycemia, transmission of data to medical professionals and caregivers: blood glucose meters with wireless glucose reporting, continuous glucose monitors, flash glucose monitors, and non-invasive glucose monitoring systems. Large scientific studies have proven the effectiveness and prospects of telemedicine technologies in the treatment of diabetes. Today, the digitalization of healthcare is actively developing from telemedicine and remote interaction with patients to new digital approaches to diagnostics and information exchange. Thus, in the Russian Federation, within the framework of the digital transformation strategy of the Healthcare industry until 2024 and for the planned period until 2030, the Personal Medical Assistants project is being implemented, aimed at creating technologies for dynamic remote monitoring of patients using platforms of centralized diagnostic services based on a unified state information system in the field of healthcare.
Characteristics of glucose variability in different types of diabetes mellitus in young patients
Authors: Ovsyannikova A. K. , Dudina M. V. , Galenok R. B. , Antonova A. O. , Rymar O. D. 
Published: June 2023

Introduction. Rare types of diabetes mellitus including MODY (Maturity-Onset Diabetes of the Young) are quite complicated to verification and differential diagnosis. That is often leads to diagnostic delays, medical errors in choosing treatment tactics. This kind of event could aggravate the course of the disease and must be prevented.Aim. Evaluation the characteristics of glucose variability (GV) in different types of diabetes mellitus (DM) in young people using continuous glucose monitoring (CGM) systems is necessary to understand the diagnostic value of the method.Materials and methods. We studied 72 patients with clinical signs of MODY who underwent a molecular genetics study to verify the type of DM. According to the results of the study, patients were divided into 3 groups: with genetically confirmed MODY2 (n = 31), MODY3 (n = 16); comparison group consists of the patients with type 2 diabetes (n = 25). All patients at the second stage underwent CGM for 14 days. At the third stage, the obtained patterns of glycemia were presented in the form of GV indices using the GLINVA program, and an in-depth analysis of glucose variability was performed.Results. Some features in the characteristics of the glycemic profile in young people with monogenic forms of DM were noticed. It was determined that in MODY2 the level of fasting plasma glucose (FPG) (p = 0.004) and HbA1c (p = 0.010) was significantly lower than in MODY3, and low GV was determined during the day, which probably causes a lower incidence of diabetic complications than other types of diabetes. In individuals with MODY3, higher FPG and HbA1c values were found, in contrast to MODY2 and type 2 diabetes. MODY3 profile is characterized with significantly higher GV and longer time spent above the target ranges (compared to type 2 diabetes).Conclusions. The approach to evaluate the glycemic profile used in the study is modern and affordable. It could become a tool for determining criteria for diagnosing the type of diabetes in patients with clinical manifestations of MODY.
Innovative technologies in the management of diabetes mellitus: prevention of hypoglycemia
Authors: Svetlova O. V. , Gurieva I. V. 
Published: June 2023

One of the strategies for preventing hypoglycemia, along with structured patient education and the use of modern hypoglycemic agents, is self-control of glycemia with the achievement of individual therapeutic goals. Frequently recurring hypoglycemic episodes are associated with impaired recognition of hypoglycemia and increase the risk of severe hypoglycemia up to six times. Prevention of the development of severe hypoglycemia may be of key importance for the prevention of adverse cardiovascular events and the risk of sudden death in patients with diabetes mellitus. Repeated hypoglycemic episodes can lead to impaired recognition of hypoglycemia, as a result of which a lower blood glucose level is necessary for the development of clinical symptoms of hypoglycemia. The use of individual glucose meters is currently relevant, despite the active introduction into clinical practice of continuous monitoring of glycemia and flash monitoring. ccording to the Russian “Algorithms of specialized medical care for patients with diabetes mellitus”, patients are recommended to conduct self-monitoring using individual glucose meters at least 4 times a day when using continuous monitoring of glycemia in real time and at least 2 times a day when using flash monitoring of glycemia to assess accuracy and / or calibration monitoring data and in order to resolve the issue of correction of ongoing therapy. The desire for strict and adequate self-control dictates the need to use the latest means of glycemia control – intelligent glucose meters with high accuracy, ease of use and reliability of blood glucose measurements. The introduction of intelligent technologies – “smart” glucose meters using a mobile application, with the functions of “no coding”, “second chance”, data transmission to the attending physician – makes it possible to carry out remote monitoring, providing more effective management of diabetes mellitus.
Electroacupuncture Inhibits Ferroptosis Induced by Cerebral Ischemiareperfusion
Authors: Wang Gui-Ling , Xu Shu-Ying , Lv He-Qun , Zhang Chao , Peng Yong-Jun 
Published: June 2023

Background:
Electroacupuncture (EA) treatment has been recommended by World
Health Organization (WHO) for years on cerebral ischemia treatment, but the specific mechanism
is still elusive. Studies have shown that EA can relieve brain damage after ischemic stroke by inhibiting
programmed cell death (PCD), such as apoptosis, necroptosis, and autophagy. Ferroptosis,
a unique form of cell death, has been highlighted recently and found to occur in I/R injury. We,
therefore, investigated whether EA plays an essential role in relieving cerebral I/R injury via ferroptosis.

Methods:
The modified MCAO/R rats model was established and then divided into four groups
with or without EA treatment. Neurological deficit score and TTC staining were used to evaluate
the neurological deficit and infarct volume of each group. Transmission electron microscope
(TEM) and immunofluorescence staining were applied for mitochondrial ultrastructure and ROS
accumulation observation, respectively. The proteins and mRNA expression of ACSL4, TFR1, and
GPX4 were assessed by western blot and qPCR to detect the progress of ferroptosis.

Results:
EA treatment improved neurological deficits and reduced infarct volume. Moreover, EA
significantly relieved the mitochondrial morphological changes and inhibited ROS Production in
MCAO rats. In terms of its mechanism, EA obviously decreased the ACSL4 and TFR1 expressions
and promoted GPX4 levels in MCAO/R model rats.

Conclusion:
These findings indicate that EA might play an essential role in relieving cerebral I/R
injury via ferroptosis.
Does Patisiran Reduce Ocular Transthyretin Synthesis? A Pilot Study of
Two Cases
Authors: Cambieri Chiara , Marenco Marco , Colasanti Tania , Mancone Carmine , Corsi Alessandro , Riminucci Mara , Libonati Laura , Moret Federica , Chimenti Cristina , Lambiase Alessandro , Conti Fabrizio , Garibaldi Matteo , Inghilleri Maurizio , Ceccanti Marco 
Published: June 2023

Background:
Variant transthyretin-mediated amyloidosis (ATTR-v) is a well-characterized
disease affecting the neurologic and cardiovascular systems. Patisiran has been approved for neurologic
involvement as it reduces hepatic synthesis of transthyretin (TTR). Eye involvement is a lateonset
feature increasing the risk of glaucoma and cataracts in patients.

Aims:
The aim of this case series was to assess whether patisiran can effectively reduce TTR synthesis
in such a barrier-protected organ as the eye.

Methods:
Two patisiran-treated ATTR-v patients underwent serum and aqueous humor sampling to
measure TTR levels detected by SDS-PAGE and immunoblotting. Serum samples were compared to
healthy control (HC), whereas aqueous humor samples were compared to non-amyloidotic subjects affected
by cataracts and glaucoma.

Results:
Serum TTR levels representative of hepatic synthesis were sharply lower in treated patients if
compared to the HC (-87.5% and -93.75%, respectively). Aqueous humor TTR levels showed mild-tono
reduction in treated patients compared to non-amyloidotic subjects with cataracts (-34.9% and
+8.1%, respectively) and glaucoma (-41.1% and -2.1%).

Conclusions:
Patisiran does not seem to be as effective in inhibiting ocular TTR synthesis as it is in
inhibiting hepatic synthesis. Re-engineering the envelope could allow the drug to target RPE cells thus
avoiding any ocular involvement.
PENGARUH UMUR PEMAKAIAN ZEOLIT ALAM DAN ARANG DALAM PENYARINGAN AIR SUMUR SISTEM ADSORPSI TERHADAP KUALITAS BAKTERIOLOGIS AIR
Authors: Yulianti Dwiana Muflihah , Aminatun Tien , Yulianti Yuliati 
Published: June 2023

Penelitian ini bertujuan untuk mengetahui efektivitas pemakaian zeolit alam dan arang dalam pengolahan air sumur sistem adsorpsi terhadap kualitas bakteriologis air ditinjau dari indeks MPN coliform dan colifekal. Selain itu juga, untuk mengetahui lama batas umur pemakaian maksimal zeolit alam dan arang dalam pengolahan air sumur sistem adsorpsi terhadap kualitas bakteriologis air. Penelitian ini dilakukan selama 3 bulan pada bulan Juni, Juli dan Agustus 2015 dengan pengecekan setiap bulan sekali dengan 3 kali ulangan. Sampel yang digunakan adalah air sumur sebelum dilewatkan dan sesudah dilewatkan pada alat penyaringan air sumur sistem adsorpsi menggunakan zeolit alam dan arang. Selanjutnya sampel air sumur tersebut dihitung nilai MPN coliform total dan colifekalnya dan dianalisis menggunakan metode deskriptif dan dikomparasikan dengan standar baku mutu air pada PERMENKES no. 416/ MENKES/ PER/ IX/ 1990. Selain itu, dilakukan penghitungan persentase efektivitas alat dalam menyaring bakteri untuk mengetahui batas pemakaian alat penyaringan air sistem adsorpsi. Hasil penelitian ini didapatkan data, nilai MPN coliform yang telah dilewatkan pada alat penyaring air sumur yaitu 34 dan 35 MPN/100 ml, sudah memenuhi kriteria baku mutu air yang ditetapkan yaitu berada ≤ 50/100 ml kecuali nilai MPN coliform air sumur pada bulan ke-0. Persentase efektivitas tertinggi alat penyaring sebesar 87,86% untuk penyaringan bakteri coliform total dan 85,20% untuk penyaringan bakteri colifekal. Persentase efektivitas alat menunjukkan kecenderungan penurunan setelah satu bulan pemakaian, sehingga batas umur pemakaian zeolit alam dan arang maksimal dalam alat penyaring air sumur sistem adsorpsi adalah satu bulan.Kata kunci: zeolit alam, arang, adsorpsi, bakteriologis air
An Intensive Exercise Program Using a Technology-Enriched Rehabilitation Gym for the Recovery of Function in People With Chronic Stroke: Usability Study
Authors: Kerr Andy , Keogh Maisie , Slachetka Milena , Grealy Madeleine , Rowe Philip 
Published: June 2023

Background
Rehabilitation improves poststroke recovery with greater effect for many when applied intensively within enriched environments. The failure of health care providers to achieve minimum recommendations for rehabilitation motivated the development of a technology-enriched rehabilitation gym (TERG) that enables individuals under supervision to perform high-intensity self-managed exercises safely in an enriched environment.

Objective
This study aimed to assess the feasibility of the TERG approach and gather preliminary evidence of its effect for future research.

Methods
This feasibility study recruited people well enough to exercise but living with motor impairment following a stroke at least 12 months previously. Following assessment, an 8-week exercise program using a TERG (eg, virtual reality treadmills, power-assisted equipment, balance trainers, and upper limb training systems) was structured in partnership with participants. The feasibility was assessed through recruitment, retention, and adherence rates along with participant interviews. Effect sizes were calculated from the mean change in standard outcome measures.

Results
In total, 70 individuals registered interest, the first 50 were invited for assessment, 39 attended, and 31 were eligible and consented. Following a pilot study (n=5), 26 individuals (mean age 60.4, SD 13.3 years; mean 39.0, SD 29.2 months post stroke; n=17 males; n=10 with aphasia) were recruited to a feasibility study, which 25 individuals completed. Participants attended an average of 18.7 (SD 6.2) sessions with an 82% attendance rate. Reasons for nonattendance related to personal life, illness, weather, care, and transport. In total, 19 adverse events were reported: muscle or joint pain, fatigue, dizziness, and viral illness, all resolved within a week. Participants found the TERG program to be a positive experience with the equipment highly usable albeit with some need for individual tailoring to accommodate body shape and impairment. The inclusion of performance feedback and gamification was well received. Mean improvements in outcome measures were recorded across all domains with low to medium effect sizes.

Conclusions
This study assessed the feasibility of a holistic technology-based solution to the gap between stroke rehabilitation recommendations and provision. The results clearly demonstrate a rehabilitation program delivered through a TERG is feasible in terms of recruitment, retention, adherence, and user acceptability and may lead to considerable improvement in function, even in a chronic stroke population.

International Registered Report Identifier (IRRID)
RR2-doi.org/10.3389/fresc.2021.820929
Tindak Tutur Komisif Politikus Pemenang Partai Pemilu di Indonesia Tahun 2019: Kajian Pragmatik
Authors: Yelmida  
Published: June 2023

Penelitian ini bertujuan untuk mengetahui adanya tuturan komisif pada pidato politikus partai pemilu di Indonesia tahun 2019. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan etnografi, fenomenologi, grounded theory, dan studi kasus. Hasil penelitian ini menunjukan: 1. Jenis tindak tutur komisif yang terdapat pada pidato politikus pemenang partai pemilu di Indonesia tahun 2019 ditemukan jenis tindak tutur berniat, berjanji, dan, menawarkan. 2. Fungsi tindak tutur komisif politikus pemenang partai pemilu di Indonesia tahun 2019 terdiri atas 43 fungsi tindak tutur berniat ditandai dengan penanda gramatikal akan . 38 fungsi tindak tutur berjanji ditandai dengan penanda gramatikal harus, akan pasti dan InsyaAllah. 3 fungsi tindak tutur menawarkan ditandai dengan penanda gramatikal dapat, menawarkan. Tuturan bersumpah tidak ditemukan. Dengan demikian, kecenderungan yang paling banyak digunakan adalah tindak tutur janji yang komisif.
Spontaneous Intracranial Hemorrhage and Oral Anticoagulation
Authors: Duquet-Armand Marie , Bouziane Amine , Arruda Alexandra , Denault Jean-Simon , Routhier Annie , Cusson Tasha , Halwagi Antoine , Williamson David , Perreault Marc , Lordkipanidze Marie , Létourneau-Guillon Laurent , Thiboutot Zoé 
Published: June 2023

Background: Canadian data on intracranial hemorrhage (ICH) associated with oral anticoagulation is limited. Objectives: Primary study outcomes were baseline hematoma volumes and in-hospital mortality in patients with ICH associated with direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs). Second-ary outcomes included the use of four-factor prothrombin complex concentrate (4f-PCC).
Methods: Retrospective cohort study of patients with ICH associated with oral anticoagulation in three ter-tiary care hospitals in Montreal, Canada, between 2011 and 2018.
Results: Twenty-nine patients were receiving DOACs and 114 patients were under VKAs. Median baseline hematoma volumes were similar, 14.8 ml [5.7–42.8] in the DOAC group and 15.6 ml [5.9–38.1] in the VKA group (p = 0.91). In-hospital mortality rate was 34.5% in the DOAC group and 48.2% in the VKA group (p = 0.26). Only 17 patients (58.6%) in the DOAC group received 4f-PCC.
Conclusion: Our study did not demonstrate significant differences in outcomes of ICH associated with DOACs versus VKAs. Management approaches were variable.
RésuméContexte: Il existe peu de données canadiennes sur l’hémorragie intracrânienne (HIC) associée à la prise d’anticoagulants par voie orale.
Objectifs: Les critères d’évaluation principaux de l’étude sont le volume initial de l’hématome et la mortalité à l’hôpital chez des patients présentant une HIC associée à la prise d’anticoagulants oraux directs (AOD) par rapport à la prise d’antagonistes de la vitamine K (AVK). Les critères d’évaluation secondaires comprennent l’utilisation d’un concentré de complexe prothrombique à quatre facteurs (4f-PCC pour four-factor prothrombin complex concentrate).
Méthodologie: Étude de cohorte rétrospective portant sur des patients présentant une HIC associée à la prise d’anticoagulants oraux dans trois hôpitaux de soins tertiaires de Montréal (Canada) entre 2011 et 2018. Résultats: Au total, 29 patients prenaient des AOD et 114 des AVK. Les volumes médians des hématomes au départ sont semblables, soit de 14,8 ml (de 5,7 à 42,8) dans le groupe des AOD et de 15,6 ml (de 5,9 à 38,1) dans le groupe des AVK (p = 0,91). Le taux de mortalité à l’hôpital est de 34,5 % pour le groupe des AOD et de 48,2 % pour celui des AVK (p = 0,26). Seuls 17 patients (58,6 %) du groupe des AOD ont reçu le 4f-PCC.
Conclusion: Notre étude ne montre aucune différence importante dans les résultats concernant l’HIC associée à la prise d’AOD par rapport à la prise d’AVK. Les méthodes de prise en charge sont variables.