bluuebunny/crossref_metadata_2025_split huggingface dataset:
MODEL UNIFIED THEORY OF ACCEPTANCE USE OF TECHNOLOGY DI PERKULIAHAN DARING
Authors: Wangi Anggun Ayu , Kustono Alwan Sri , Effendi Rochman 
Published: January 2023

This study aims to analyze the effectiveness of online lectures for accounting students at Jember University by utilizing a technology acceptance model called the Unified Theory of Acceptance Use of Technology (UTAUT) model. This study uses primary data obtained directly from the respondents. The data collection process was carried out by distributing questionnaires online via google form. The sampling technique in this study used a random sampling method. We determine the number of samples using the Slovin formula. We used SPSS software version 25 and AMOS version 21 to process the data questionnaire. The results of the analysis in the study showed that there was a significant positive relationship between performance expectations and students' behavioral intentions when studying boldly. This is inversely proportional to the results between business expectations and behavioral intentions which do not have a significant positive result. Social influence has a significant positive effect on behavioral intentions when learning. The condition of the facility has no positive effect on behavioral intentions. Intention to behave positively towards using behavior. Furthermore, using behavior has a positive effect on the GPA. These results indicate that the online course for accounting students at the University of Jember is running effectively.Keywords: Effectiveness, Online Lecture, UTAUT

ABSTRAK
Penelitian ini bertujuan untuk menganalisis efektivitas perkuliahan daring bagi mahasiswa Akuntansi Universitas Jember dengan memanfaatkan sebuah model penerimaan teknologi yang bernama model Unified Theory of Acceptance Use of Technology (UTAUT). Penelitian ini menggunakan data primer yang didapat secara langsung dari responden. Proses pengambilan data dilakukan dengan penyebaran kuesioner secara online melalui google form. Teknik pengambilan sampel dalam penelitian ini menggunakan metode pemilihan sampel secara acak (randomly sampling method). Penentuan banyaknya jumlah sampel menggunakan rumus Slovin. Pengolahan data kuesioner dalam penelitian ini menggunakan software SPSS versi 25 dan AMOS versi 21. Hasil analisis pada penelitian menunjukkan bahwa terdapat hubungan positif signifikan antara ekspektasi kinerja dengan niat berperilaku mahasiswa pada saat perkuliahan daring. Hal ini berbanding terbalik dengan hasil antara ekspektasi usaha dengan niat berperilaku yang tidak memiliki hasil secara positif signifikan. Pengaruh sosial berpengaruh positif signifikan terhadap niat berperilaku pada saat perkuliahan daring. Kondisi fasilitas tidak berpengaruh secara positif terhadap niat berperilaku. Niat berperilaku berpengaruh secara positif terhadap perilaku menggunakan. Selanjutnya yaitu perilaku menggunakan berpengaruh secara positif terhadap Indeks Prestasi. Hasil ini menunjukkan bahwa kuliah daring bagi mahasiswa Akuntansi Universitas Jember berjalan efektif.Kata Kunci: Efektivitas, Perkuliahan Daring, UTAUT
Uplifting mountains and shaking deserts: volcano-tectonic earthquakes revealed by soft-sediment-deformation structures in Upper Cretaceous aeolian deposits
Authors: Alessandretti Luciano , Warren Lucas V. , Varejão Filipe G. , Rassi Raul , Dos Santos Maurício G.M. , Silva Mariana N.M. , Honorato Fernando R. , Estrada Michele J.T. , Cunha João V.O. 
Published: January 2023

ABSTRACT
During the last stages of Gondwana fragmentation, large regions of the newly formed South American continent were covered by extensive deserts. Some parts of this continental landmass were synchronously affected by pronounced tectonism and magmatism, which were responsible for reshaping the regional topography. In this context, the southwestern part of the Sanfranciscana Basin in central Brazil is a key area for understanding this particular period in the geodynamic evolution of the South American continent. Aeolian deposits of the Posse Formation in the basin occur in direct association with volcanic rocks of the Upper Cretaceous Mata da Corda Group. Here, we report evidence of synsedimentary magmatism in direct association with soft-sediment-deformation structures, including flame structures, load casts and pseudonodules, water-escape structures, convolute lamination, faults, breccias, and clastic dikes, developed exclusively in aeolian sandstone and siltstone facies. The deformation features are interpreted as indicative of liquefaction, fluidization, and brittle behavior of the loose to partially lithified, wet sandy–silty sediments. The Late Cretaceous aeolian sedimentation is contemporaneous with the uplift of the Paranaíba High and associated magmatism in the Minas–Goiás Alkaline Province. In this context, these significant volcano-tectonic activities are considered to have triggered ductile to brittle deformation in the reported aeolian deposits.
Identification of the function, immunological role and m6A modification of MYSM1 in head and neck squamous cell carcinoma
Authors: Wang Nan , Huang Xuanyu , Cheng Jinsheng 
Published: January 2023

Abstract
Background:MYSM1 displays vital roles in hematopoiesis and lymphocyte development. However, the prognosis, immune infiltration and m6A modification role of MYSM1 in Head and Neck squamous carcinoma (HNSC) remains unexplored.
Methods: A comprehensive bioinformatics analysis was used to identify the expression profiles and prognosis of MYSM1 in pan-cancer through multiple databases. TIMER and CIBERSORT database were used to analyze the relationship between MYSM1 expression and immune infiltration. GSEA and R language was utilized to estimate the functional enrichment analysis of MYSM1 in HNSC. The TCGA-HNSC cohort was used to investigate the relationship between MYSM1 expression and m6A modification in HNSC.
Results: MYSM1 was differentially expressed in a variety of cancers including HNSC, and highly MYSM1 expression was associated with favorable overall survival (OS) and histological grade. CIBERSORT analysis showed that MYSM1 expression was significantly correlated with the infiltration of multiple immune cells. And the specific mechanism of MYSM1 regulating immune infiltration may be involved in the PD-L1 expression and PD-1 checkpoint pathway in cancer and TNF signaling pathway. TCGA-HNSC cohort analysis revealed that MYSM1 expression was related to 9 m6A modifier genes.
Conclusion: Our comprehensive study found that MYSM1 can serve as a prognostic biomarker for determining prognosis, and is correlated with tumor immune infiltrating cells and m6A modification.
Compression of images with a mathematical approach based on sine and cosine equations and vector quantization (VQ)
Authors: Ghadami Raheleh , Rahebi Javed 
Published: January 2023

Abstract
Image compression is one of the most attractive and practical topics. Without image compression, the image size becomes too large for storage. The transmission of uncompressing images on computer networks slows down and network bandwidth is wasted. Various approaches to image compression have been proposed so far, one of which is vector quantization using mathematical concepts and image processing to compress images. The LBG algorithm is a practical algorithm for compressing images using vector quantization concepts. Most researchers have used meta-heuristic and optimization algorithms with a modeling approach of swarm behavior of living things to improve the quality of the LBG compression algorithm. This study uses a meta-heuristic method based on sine and cosine algorithms (SCA) to improve the quality of the image compression algorithm. In the proposed mathematical modeling method, the SCA algorithm is improved using spiral equations. The improved SCA algorithm is then used to find the optimal codebook in the LBG compression algorithm. Finding a better codebook in the proposed method will increase the quality of the compression images. The proposed method implemented in MATLAB software and experiments showed that the PSNR index in the proposed method improve the ratio of the LBG algorithm by about 13.73%. Evaluations show that the PSNR index of compressed images in the proposed method is higher and better than PBM, CS-LBG, FA-LBG, BA-LBG, HBMO-LBG, QPSO-LBG, PSO-LBG. The result shows the proposed method (or ISCA-LBG) has less time complexity than HHO and WOA compression algorithms.
Epi-Clock: A sensitive platform to help understand pathogenic disease outbreaks and facilitate the response to future outbreaks of concern.
Authors: Ji Cong , Shao Junbin Jack 
Published: January 2023

Abstract
The lack of virus fossilization precludes any references or ancestors for inferring evolutionary processes, and viruses have no cell structure, metabolism, or space to reproduce outside host cells. Most mutations yielding high pathogenicity become removed from the population, but adaptive mutations could be epidemically transmitted and fixed in the population. Therefore, determining how viruses originated, how they diverged and how an infectious disease was transmitted are serious challenges. To predict potential epidemic outbreaks, we tested our strategy, Epi-Clock, which applies the ZHU algorithm on different SARS-CoV-2 datasets before outbreaks to search for real significant mutational accumulation patterns correlated with the outbreak events. We imagine that specific amino acid substitutions are triggers for outbreaks. Surprisingly, some inter-species genetic distances of Coronaviridae were shorter than the intra-species distances, which may represent the intermediate states of different species or subspecies in the evolutionary history of Coronaviridae. The insertions and deletions of whole genome sequences between different hosts were separately associated with new functions or turning points, clearly indicating their important roles in the host transmission and shifts of Coronaviridae. Furthermore, we believe that non-nucleosomal DNA may play dominant roles in the divergence of different lineages of SARS-CoV-2 in different regions of the world because of the lack of nucleosome protection. We suggest that strong selective variation among different lineages of SARS-CoV-2 is required to produce strong codon usage bias, significantly appear in B.1.640.2 and B.1.617.2 (Delta). Interestingly, we found that an increasing number of other types of substitutions, such as those resulting from the hitchhiking effect, have accumulated, especially in the pre-breakout phase, even though some previous substitutions were replaced by other dominant genotypes. From most validations, we could accurately predict the potential pre-phase of outbreaks with a median interval of 5 days before. Using our pipeline, users may review updated information on the website https://bioinfo.liferiver.com.cn with easy registration.
Hippocampal Subregions Volume and Texture for the Diagnosis of Mild Cognitive Impairment
Authors: Chu Tongpeng , Liu Yajun , Zhang Zhongsheng , Zhang Gang , Dong Fanghui , Dong Jianli , Lin Shujuan 
Published: January 2023

Abstract
Purpose: The aim of this study was to examine the diagnostic efficacy of hippocampal subregions volume and texture in differentiating amnestic mild cognitive impairment (MCI) from normal aging changes.
Materials and Methods: Ninety MCI subjects and eighty-eight well-matched healthy controls (HCs) were selected from the ADNI-1 or ADNI-2 Database.Twelve hippocampal subregions volume and texture features were extracted using Freesurfer and MaZda based on T1 weighted magnetic resonance images. Then, two-sample t-test and Least Absolute Shrinkage and Selection Operator (LASSO) regression were developed to select a subset of the original features. Finally, a support vector machine (SVM) was used to perform the classification task and the area under the curve (AUC), sensitivity, specificity, and accuracy were calculated to evaluate the diagnostic efficacy of the model.
Results: The volume features with high discriminative power were mainly located in the bilateral CA1 and bilateral CA4, while texture feature were gray-level non-uniformity, run length non-uniformity and fraction. Our model based on hippocampal subregions volume and texture features achieved better classification performance with an AUC of 0.90.
Conclusions: Based on hippocampal subregions volume and texture can be used to diagnose MCI. Moreover, we found that the features that contributed most to the model were mainly textural features, followed by volume. These results may guide future studies using structural scans to classify patients with MCI.
Assessment of the activity of tigecycline and colistin on biofilm producer Klebsiella pneumoniae isolated from COVID-19 patients, Iran
Authors: Rahimi Sara , Bakht Mehdi , peymani Amir , Farshadzadeh Zahra , Ehteram Hasan , Bakhshi Ashraf , Nikkhahi Farhad , khakpour mohadeseh 
Published: January 2023

Abstract
Background
Pneumonia caused by β-lactamase-producing Klebsiella pneumoniae is encountered in hospitals. We aimed to investigate the activity of tigecycline, colistin and other selected antibiotics against 27 β-lactamase-producing Klebsiella pneumonia isolated from bronchoalveolar lavage (BAL) in COVID-19 patients.
Methods
In the current survey phenotypic screening of ESBL, AmpC, and carbapenemase enzymes was carried out. Detection of ESBL, AmpC, and carbapenemase genes was also performed by the PCR method. Biofilm formation was assessed by staining with 1% crystal violet. Finally, a set of the virulence-encoding genes were detected by the PCR method.
Results
This study demonstrated the high percentage of ESBL and carbapenemase-producing Klebsiella pneumoniae among COVID-19 patients. Tigecycline and colistin were more effective against these isolates. ESBL associated genes were detected in (18 (66.7%) blaTEM, 27 (100%) blaSHV, and 18 (66.7%) blaCTX−M) isolates. Also, carbapenemase-related genes were detected in 16 (59.3%) isolates. The prevalence of these genes were blaOXA−48−like 14(51.9%), and blaNDM1 2 (7.4%). Twenty-seven isolates exhibited biofilm formation. Molecular distribution of virulence genes revealed that 92.59%, 92.5%, 88.88%, 11.11% and 18.5% of the isolates carried entB, mrkD, Irp2, fimH and magA genes, respectively. MLST results for four colistin-resistant isolates showed three different sequence types-ST: ST3500, ST273, and 2 cases of ST2558.
Conclusion
The results of this study demonstrated the prevalence of infections caused by β-lactamase-producing Klebsiella pneumoniae, which are biofilm producers among respiratory hospitalized Patients. The effective antimicrobial activity of tigecycline to the bacteria that produce these enzymes may be efficient in faster and better treating COVID-19 patients which are hospitalized.
Sustainable Bioethanol Production by Solid State Fermentation: A Systematic Review
Authors: Ruslan Nur Fathin , Ahmad Noormazlinah , Abas Azlan , Sanfilippo Antonio , Mahmoud Khaled , Munaim Mimi Sakinah Abdul , Nour Abdurahman Hamid 
Published: January 2023

Abstract

Escalation of the global population has accelerated the demand for sustainable energy sources such as bioethanol. Traditionally, bioethanol has been produced using fossil fuels, which are non-renewable, non-sustainable, and not eco-friendly. Thus, there is a need to develop new technologies and low-cost raw materials in order to ensure that bioethanol is economically comparable to traditional fossil fuels. Solid-state fermentation (SSF) has been in the limelight within the scientific community because of its efficiency, cost-effectiveness, and promising technology to produce various products such as postbiotics and bioethanol. SSF involves the cultivation of microorganisms on solid substrate with the absence of free-flowing water, which eliminates the need for sugar extraction and reduces wastewater production. This systematic review provides an overview of the applications of SSF in bioethanol production while presenting recent studies and advancements of this technology for producing sustainable and cost-effective bioethanol.
Life cycle environmental impacts of wine grape production in Gansu, China
Authors: Wang Yaolin , Sun Tao , Li Yinke , Milne Eleanor , Yang Yanjun , Liu Kailin , Li Jinhui , Zhao Chuanyan , Yan Peiying , Li Shuo , Li Jingjing , Wan Xiang , Duan Bin , Wang Wei 
Published: January 2023

Abstract

Gansu, one of China’s major viniculture regions, is transforming its wine industry to a green production pattern. This study aims to delve into the environmental impacts associated with wine grape production in Gansu using life cycle assessment (LCA). Results show that the impacts of non-renewable energy consumption (NR) and global warming potential (GWP) are higher in the pre-farm stage than those in the on-farm phase. Nitrogen fertilizer (N) production and electricity generation contribute the most in the pre-farm stage, while N2O emission dominates the GWP impact in the on-farm phase. In contrast, the impacts of AP and EP in the on-farm stage are higher than their pre-farm counterparts. Organic fertilizer and N production as well as electricity generation are the main contributors to AP in the pre-farm stage, whereas NH3 emission predominates the on-farm impact category. Pesticide production contributes the most to EP in the pre-farm stage, while emission dominates the on-farm emission. N2O, NH3 and emissions are mainly the result of N application. Technological innovation, policy tools, precise and efficient fertilization, regulated deficit irrigation, alternate drip irrigation are all priorities to mitigate the environmental burden.
A picogram BA-ELISA quantification assay for rLj-RGD3, a platelet fibrinogen receptor antagonist, in the rat plasma and its application to a pharmacokinetic study
Authors: Wang Yuping , Liu Zhien , Han Guozhu , Yu Ping , Yang Xiaobo , Wang Jihong , Lv Li 
Published: January 2023

Abstract
rLj-RGD3, a new member of RGD-motif toxin protein family derived from Lampetra japonica by means of DNA recombinant technique, has been demonstrated to be a platelet fibrinogen receptor antagonist. The present article aims to report an innovative validated highly sensitive and specific biotin-avidin enzyme linked immunosorbent assay (BA-ELISA) in order to provide a bio-analytical method for its pharmacokinetic (PK) study. The concentration of rLj-RGD3 in rat plasma was measured at a picogram level by the developed double sandwich BA-ELISA assay, which used two different mouse anti-rLj-RGD3 monoclonal antibodies as capture antibody and detection antibody, respectively, directed at different epitopes. The method was validated to be highly specific (no interference with the detection from blank plasma), precise (RSD <10%) and accurate (94%-104%). The absolute recovery was as high as 94%-105%. The calibration curve showed good linearity ranging from 50 to 1600 pg/mL. The LOQ was found to be as low as 50 pg/mL. The above validated assay was successfully employed for the assessment of PK disposition of rLj-RGD3 in rats. After i.v. and s.c. dosing 30 µg/kg the rLj-RGD3 plasma concentration declined biexponentially with time, which could be best fitted by the two-compartment model. In conclusion, the BA-ELISA method reported here was proved to completely meet requirements for PK study of rLj-RGD3 with effective pharmacological dose at µg/kg BW level.
Acoustic-Driven Magnetic Skyrmion Motion
Authors: Yang Yang , Zhao Le , Yi Di , Xu Teng , Chai Yahong , Zhang Chenye , Jiang Dingsong , Ji Yahui , Jiang Wanjun , Tang Jianshi , Yu Pu , Wu Huaqiang , Nan Tianxiang 
Published: January 2023

Abstract
Magnetic skyrmions have great potential for developing novel spintronic devices. The electrical manipulation of skyrmions has mainly relied on current-induced spin-orbit torques. A recent theoretical model suggested that the skyrmions could be more efficiently manipulated by surface acoustic waves (SAW), an elastic wave that can couple with magnetic moment through magnetoelastic effect. However, the directional motion of skyrmions that is driven by SAW is still missing. Here, we experimentally demonstrate the motion of Néel-type skyrmions in Ta/CoFeB/MgO/Tamultilayers driven by propagating SAW pulses from on-chip piezoelectric transducers. Our results revealthat the elastic wave with longitudinal and shear vertical displacements (Rayleigh wave) traps skyrmions, while the shear horizontal wave effectively drives the motion of skyrmions. In particular, a longitudinal motion along the SAW propagation direction and a transverse motion due to topological charge, are observed and further confirmed by our micromagnetic simulations. This work demonstrates a promising approach based on acoustic waves for manipulating skyrmions, which could offer new opportunities for ultra-low power spintronics.
A Smartphone Application for Postoperative Care with an Instant Feedback System after Cataract Surgery
Authors: Wu Ming-Han , Wu Pei-Chang , Hseih Long-Bing , Lin Li-Man , Tsai Chia-Ling 
Published: January 2023

Abstract
Purpose: Outpatient postoperative periodic visits still lack information for the early detection of patients with initial infection or other serious conditions after cataract surgeries. We developed and accessed a postoperative care smartphone application (PC app) for patients to self-record and report postoperative symptoms/signs with an instant bidirectional feedback system.
Methods: The PC app alerted the patient to report and grade six ocular symptoms/signs associated with endophthalmitis or retinal detachment. Patients used the PC app for 7 days postoperatively to assess their symptoms/signs 4 times a day after receiving an alert. The data automatically collected using a cloud computer system judged the grade and sent messages to medical staff for further medical assistance. User information and satisfaction were collected from the questionnaire on the 7th day.
Results: 50 patients participated. There were two reports of symptom grade deterioration (increased photopsia and fever) in two patients. 81% of patients were satisfied or very satisfied to communicate their symptoms instantly with the app, 86% reported the app to be helpful, and 81% opined to use it again. While, 79% of patients considered the PC app to improve the quality of postoperative care, 86% found it helpful for seeking medical assistance. Critical themes included less willingness to look at smartphones after eye surgery, lack of a footnote area, and the need for more medical education.
Conclusion:
This novel PC app for self-reporting of postoperative symptoms and instant bidirectional feedback system could be useful for cataract patients. It was perceived to be satisfactory and improve the quality of patient care after cataract surgery.