bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sonographic ductal changes and pertinent characteristics that associate with proliferative lesions of breast
Authors:   , Rengganis Anggraeni 
Published: April 2023

Managing for sonographic focally thick duct lesions is not established in practice guidelines. Most cases showed scant cells on fine-needle aspiration (FNA). The study aimed to detect any variables that could predict proliferative lesions of the ducts and avoid unnecessary biopsies. A retrospective cohort design was done to analyze the association between ultrasound (US) variables and the outcome of proliferative or non-proliferative ductal lesions, determined by corresponding histopathology or cytology on consecutive follow-ups for at least three years. The data collection from 2015-2017 at King Chulalongkorn Memorial Hospital showed that 199 female patients with 210 index lesions met the eligibility criteria, 56.3% were the patients on screening (setting#1), 22.1% were examined for symptomatic lesions (setting#2), and 21.6% were treated breast cancer in follow-up (setting#3). The patients' age was categorized into <50 and ≥50 years old with a ratio of 53:47. The presence of the six associated US parameters was as follows; internal nodularity (65.7%), mixed echoic wall (41.0%), location at the periphery (69.0%), vascularity (35.2%), calcification (39.5%), and mean diameter of 4.50 (SD 1.43) mm. Of the final outcome, 71 cases had proliferative ductal lesions (18 of which were malignant). The non-proliferative disease was found in 66.2% of cases (52.4% yielded scanty cells on FNA). The regression model depicted vascularity as the single fixed predictor with an odds of 2.21 (95%CI 1.16, 4.19). The age cutoff at 50 and settings#2, #3 categories did not fit well when added to the model with OR of 1.17 (95%CI 0.62, 2.22), 1.87 (95%CI 0.90, 3.87), 0.55 (95%CI 0.23, 1.30), respectively. In conclusion, feeding vessels are a pertinent parameter to be a predictor of proliferative lesions. Focally thick ducts without associated parameters seem not worrisome, and only observation is merited.
Adaptation strategies for survival of hotel business entrepreneurs in Chiang Mai to COVID-19 situation in 2020
Authors:   , Paepuang Priya 
Published: April 2023

This research aims to explore the adaptation strategies for the COVID-19 pandemic by hotel entrepreneurs in Chiang Mai. Data was mainly collected from 154 hotels categorized into 4 types by Department of Provincial Administration and Online Travel Agency (OTA). Data analysis was conducted through data collecting week-by-week from 1st February to 31st December 2020 and the relationship of measurements and adaptation indicators was diagrammed. Moreover, this research interviewed four entrepreneurs of hotel type 2 in two areas including Nimmanahaeminda Road and the Old town. There are three major findings: 1. The target group is different in different locations. For example, the consumer focus group of hotels located in Nimmanahaeminda Road is mainly Thai guests. Its average price trend is positive. 2. The opening and closure of each location reflects adaptation strategies. For example, hotel type 4 located in the Old Town was closed approximately 63 days. 3. Adapting strategies of Chiang Mai's hotel entrepreneurs can be applied in the short-run; however, in the long-run, GPP and GDP can be driven by international travel demand.
Determining the effectiveness of the health-EDRM framework and twitter data analysis as the near real-time source of information during the COVID-19 situation
Authors:   , Saengtabtim Kumpol 
Published: April 2023

Coronavirus pandemic or COVID-19 pandemic is considered to be one of the most severe disasters that affect both lives and economics to all the countries around the world. Health Emergency and Disaster Risk Management Framework or HEALTH-EDRM framework is the disaster management framework established in late 2019. One objective of this framework is to reduce the impact of the disaster that affects the lives of the people. Risk communication which is considered as the main function of this framework is also the main key for reducing the amount of affecting people. In this research, the analysis of the effectiveness of the HEALTH-EDRM framework will be defined based on the amount of the COVID-19 affected, death, and the ratio of death and affected cases in Asia Oceania. The paired t-test analysis will be used to compare the effectiveness for dealing with the COVID-19 situation in the aspect of the member of the framework and the economic situation. Furthermore, the Twitter microblogging platform will be defined as whether it can be used for risk communication function in terms of nearly real-time and reliable property. The analysis will be performed by comparing the content between the WHO’s situation report and the Twitter data from 21 January 2020 until 16 August 2020 based on daily, weekly, monthly, and quarterly based. The Latent Dirichlet Allocation (LDA) and Cosine Similarity will be used as the tools for generating topics and comparing the similarity. The results of both analyses show that even though the HEALTH-EDRM framework did not perform well to help their members for dealing with the COVID-19 situation, this framework can perform well for helping the least developed countries. In addition, Twitter is proved to be useful as a near real-time and reliable source of information.
Iterative roots of two-dimensional mappings
Authors: Yu Zhiheng , Li Lin , Matkowski Janusz 
Published: April 2023

AbstractAs a weak version of embedding flow, the problem of iterative roots is studied extensively in one dimension, especially in monotone case. There are few results in high dimensions because the constructive method dealing with monotone mappings is unavailable. In this paper, by introducing a kind of partial order, we define the monotonicity for two-dimensional mappings and then present some results on the existence of iterative roots for linear mappings, triangle-type mappings, and co-triangle-type mappings, respectively. Our theorems show that even the property of monotonicity for iterative roots of monotone mappings, which is a trivial result in one dimension, does not hold anymore in high dimensions. At the end of this paper, the problem of iterative roots for two well-known planar mappings, that is, Hénon mappings and coupled logistic mappings, are also discussed.
The Healing through Arts (HeARTS) program for children bereaved by cancer: Pilot study findings from Singapore
Authors: Ong Saryna , Loh Travis , Wong Phyllis , Teo Irene 
Published: April 2023

AbstractObjectivesThe article aims to investigate the feasibility, acceptability, and initial efficacy of a short-term 3-day art therapy group for children who have experienced parental death to cancer.MethodsThe study utilized a pretest–posttest design and included children (n = 20) aged 7–12 years. The feasibility of the intervention was measured by recruitment ability, study compliance, and intervention adherence, while acceptability was assessed using a child-reported satisfaction survey. Efficacy was examined using the child-reported Pediatric Quality of Life Inventory (PedsQL), while the emotional, social, and behavioral functioning of children was measured using the parent-reported Strengths and Difficulties Questionnaire. Paired sample t-tests were used for analyses.ResultsThe intervention was found to be feasible (80% recruitment rate and 100% session adherence). Acceptability was high, and all participants were satisfied and found the intervention to be helpful. While results did not reach statistical significance, improvements in psychosocial and physical quality of life were reported by all the children post-intervention and at the 3-month follow-up. Parent-reported a decrease in behavioral difficulties scores and an increase in prosocial behavior scores at post-intervention and at the 3-month follow-up.Significance of resultsThe 3-day art therapy group intervention was shown to be feasible to conduct and acceptable to the recipients. The intervention shows promise in improving post-death adjustment and quality of life outcomes of children bereaved by parental death due to cancer that were maintained after 3 months. The use of art therapy groups to ameliorate difficulties associated with parental loss and to assist children in coping day-to-day difficulties should be further investigated.
Vanguards of the counter-revolution: the far–right and the French Army’s guerre révolutionnaire doctrine
Authors: Cooney Cian 
Published: April 2023

Abstract
Guerre révolutionnaire doctrine was conceived of as a riposte to the new form of warfare which the French Army encountered and fell victim to in Indochina. Taking inspiration from both the Indochina experience and communist writers, the doctrine inevitably advocated and replicated totalitarian tactics and methods. One of its major tenets was the intrusion of the army into the realm of politics, an incursion which resulted in huge turmoil. Previous studies have centred on a discussion of the doctrine itself, with limited consideration of its impact within political circles. The current article seeks to address this gap in the literature with an exploration of far-right ideological precepts present in guerre révolutionnaire doctrine and to explain why this doctrine struck a chord with l’extrême-droite in France. Given the extent of far-right political action during the Algerian War in defence of l’Algérie française, an examination of this connection is of significant interest.
Social distinctions of directors and firm performance
Authors: Ramachandra Suresh , Rahman Asheq 
Published: April 2023

PurposeThis paper aims to examine the effects of the social distinction of company directors on firm performance.Design/methodology/approachThe social distinction of company directors adds to the firm’s reputation, allowing the firm to access resources and privileges. The indicators of social distinction this study uses are the prenominal titles of directors in Malaysian companies. As Malaysian companies are known to have directors with political connections and the prenominal titles can be intertwined with these connections, to ascertain the effects of social distinction on firm performance, this study examines whether social distinctions proxy and complement political connections in improving firm performance. This study uses Tobin’s Q (TQ) for longer-term performance and gross sales for current-year performance.FindingsThis study finds evidence to suggest that the impact of higher-order titles on Tobin’s Q and sales is greater in politically unconnected firms than in connected firms. This study also finds evidence to suggest that higher-order titles amplify the effect on Tobin’s Q in politically connected firms, whereas lower-order titles amplify sales, both moderated by firm-age. The findings shed light on the mediating variables that contribute to the above, and are robust for alternative performance measures, and account for endogeneity concerns.Research limitations/implicationsThe results are generalisable only to countries where social distinctions are of significance.Practical implicationsFuture research on political connections should consider social connections that affect firms. Also, such research should prompt the awarders of titles to prohibit the use of titles for pecuniary motives to minimise market imperfections.Originality/valueAdding to the prior literature on the characteristics of directors and firm performance, this study shows that the social distinctions of directors do matter.
The drivers and barriers of telecommuting: The case of Lebanon during COVID‐19
Authors: Ismail Hussein , Blaique Lama , Syagha Ola 
Published: April 2023

AbstractThis study aims to investigate the barriers and drivers relating to telecommuting as a mode of work in the wake of the coronavirus pandemic. Using a qualitative research design, data from 30 interviews conducted with employees from different departments and specialties in Lebanon were analysed. The results reveal three main themes, namely, technological context, organisational context and national context in relation to the experiences of workers telecommuting during the pandemic. There are limited studies that examine telecommuting in the Middle East region in general and in Lebanon in particular. The study highlights the benefits of telecommuting and offers several organisational and contextual implications that would enhance the adoption of telecommuting in the Middle East region.
Supplementary Figures S1 and S2 from Fluorouracil Enhances Photodynamic Therapy of Squamous Cell Carcinoma via a p53-Independent Mechanism that Increases Protoporphyrin IX levels and Tumor Cell Death
Authors: Anand Sanjay , Rollakanti Kishore R. , Brankov Nikoleta , Brash Douglas E. , Hasan Tayyaba , Maytin Edward V. 
Published: April 2023

<p>Figure S1.	UVB-induced squamous cell carcinoma (SCC) of the skin, when treated with 5-FU, shows increased expression of the differentiation marker E-cadherin, relative to vehicle treatment alone. Figure S2.	Pretreatment of cutaneous UVB-induced SCC with 5-FU prior to PDT causes enhanced tumor cell death, as measured by TUNEL and by H&E histological staining.</p>
Abstract 6235: Discovery of novel HDAC6 inhibitors that enhance proteasomal activity to boost antigen presentation and trigger anti-myeloma T-cell immunity
Authors: Rana Priyanka S. , Ignatz-Hoover James , Driscoll James J. 
Published: April 2023

Abstract
Transformative success of cancer immunotherapy has revolutionized cancer treatment and can induce long lasting responses in patients with cancers from a wide range of histologies. However, only a fraction of patients respond to immunotherapy and cancer cells escape immunosurveillance through molecular mechanisms that remain elusive. Proteasomes play a central role in the immune response by generating peptides from intracellular antigens which are presented on the cell surface for recognition by CD8+ cytotoxic T lymphocytes (CTLs). Malignant cells employ strategies to downregulate antigen presentation and impair CTL-mediated tumor recognition and lysis. Recently, we discovered that HDAC6-specific inhibitors increased intracellular proteasome activity and the generation of antigenic class I MHC peptides. However, current HDAC6 inhibitors have pharmacologic liabilities that limit efficacy, e.g., low potency and solubility, poor pharmacokinetic properties and potential genotoxicity. Therefore, we performed a cell-based, high-throughput screen (HTS) of 9,600 HDAC-specific compounds to identify novel compounds that increased proteasomal activity in myeloma cells. We identified 8 hits that increased proteasomal activity at least two-fold. Importantly, two novel molecules identified in the HTS increased proteasome activity more potently and more rapidly than the HDAC6-specific inhibitors Tubastatin-A and ACY-1215 (Ricolinostat) with comparatively low cytotoxicity. Proteasomes degrade chicken ovalbumin (Ova) to generate the immunodominant antigen SIINFEKL presented at the cell surface complexed with the MHC-class I molecule H-2Kb. Treatment of tumor cells with Tubastatin-A and ACY-1215 increased levels of the MHC-class I-SIINFEKL complex by ~3-fold. Tumor cells were pretreated with Tubastatin-A and ACY-1215 and then co-cultured with CTLs that had been genetically-engineered to express a SIINFEKL-restricted T-cell receptor (TCR). Pre-treatment of lymphoma or multiple myeloma cells with novel HDAC6 inhibitors also increased tumor lysis by CTLs that expressed the SIINFEKL-restricted TCR by 2-fold. Taken together, our results support repositioning pharmacologics that inhibit HDAC6 to activate proteasomal generation of antigenic peptides and boost antigen presentation as cancer immunotherapeutics.
Citation Format: Priyanka S. Rana, James Ignatz-Hoover, James J. Driscoll. Discovery of novel HDAC6 inhibitors that enhance proteasomal activity to boost antigen presentation and trigger anti-myeloma T-cell immunity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6235.
Supplementary Tables and Figures S1-S8; Material and Methods from Functional TCR Retrieval from Single Antigen-Specific Human T Cells Reveals Multiple Novel Epitopes
Authors: Simon Petra , Omokoko Tana A. , Breitkreuz Andrea , Hebich Lisa , Kreiter Sebastian , Attig Sebastian , Konur Abdo , Britten Cedrik M. , Paret Claudia , Dhaene Karl , Türeci Özlem , Sahin Ugur 
Published: April 2023

<p>Supplementary Table S1.	Primers used in this study. Supplementary Table S2. A/B	Coverage of TCR-α (A) and TCR-β (B) variable genes with clonotype-specific primers. Supplementary Table S3.	Characteristics of cloned TCRs. Supplementary Figure S4.	Flow cytometric sorting of pp65-specific CD8+ T cells from CMV-seropositive donor ID3 after one week of expansion. Supplementary Table S5.	Synthetic peptides used in this study. Supplementary Figure S6.	Functionality of TCRCD8-NY#5 in CD4+ and CD8+ T cells. Supplementary Figure S7.	Functionality of NY-ESO-1-specific CD4-TCRs in CD8+ T cells. Supplementary Table S8.	HLA haplotypes from healthy donors and NSCLC patients. Supplementary Methods.	Detailed materials and methods.</p>
Figure S2 from CD86<sup>+</sup> Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses
Authors: Wennhold Kerstin , Thelen Martin , Lehmann Jonas , Schran Simon , Preugszat Ella , Garcia-Marquez Maria , Lechner Axel , Shimabukuro-Vornhagen Alexander , Ercanoglu Meryem S. , Klein Florian , Thangarajah Fabinshy , Eidt Sebastian , Löser Heike , Bruns Christiane , Quaas Alexander , von Bergwelt-Baildon Michael , Schlößer Hans A. 
Published: April 2023

<p>Supplementary Figure 2: Gating strategy for flow cytometry. Live CD45+ cells were gated after live/dead discrimination and removal of doublets as shown.</p>
Data from Combination IFNβ and Membrane-Stable CD40L Maximize Tumor Dendritic Cell Activation and Lymph Node Trafficking to Elicit Systemic T-cell Immunity
Authors: Zheng Hong , Yu Xiaoqing , Ibrahim Mohammed L. , Foresman Dana , Xie Mengyu , Johnson Joseph O. , Boyle Theresa A. , Ruffell Brian , Perez Bradford A. , Antonia Scott J. , Ready Neal , Saltos Andreas N. , Cantwell Mark J. , Beg Amer A. 
Published: April 2023

<div>Abstract<p>Oncolytic virus therapies induce the direct killing of tumor cells and activation of conventional dendritic cells (cDC); however, cDC activation has not been optimized with current therapies. We evaluated the adenoviral delivery of engineered membrane-stable CD40L (MEM40) and IFNβ to locally activate cDCs in mouse tumor models. Combined tumor MEM40 and IFNβ expression induced the highest cDC activation coupled with increased lymph node migration, increased systemic antitumor CD8<sup>+</sup> T-cell responses, and regression of established tumors in a cDC1-dependent manner. MEM40 + IFNβ combined with checkpoint inhibitors led to effective control of distant tumors and lung metastases. An oncolytic adenovirus (MEM-288) expressing MEM40 + IFNβ in phase I clinical testing induced cancer cell loss concomitant with enhanced T-cell infiltration and increased systemic presence of tumor T-cell clonotypes in non–small cell lung cancer (NSCLC) patients. This approach to simultaneously target two major DC-activating pathways has the potential to significantly affect the solid tumor immunotherapy landscape.</p></div>
The effects of chemotherapy, primary tumor location and histological subtype on the survival of stage III colon cancer patients
Authors: Zhou Chenghui , Lu Liqing , Huang Qiulin , Tang Zhen , Tang Rong , Xiao Zhongsheng , Xiao Shuai 
Published: April 2023

Abstract
Objective
Colon cancer (CC) is one of the most common cancers worldwide and has a poor prognosis. Surgery followed by adjuvant chemotherapy is the standard treatment strategy for stage III CC patients. Primary tumor location (PTL) is an important factor for the long-term survival of CC. However, the difference in the prognosis between the histological subtypes of mucinous adenocarcinoma (MAC) and nonspecific adenocarcinoma (AC) in stage III CC patients is unclear. The correlation of chemotherapy, PTL and histological subtype with the overall survival (OS) of stage III CC patients has not yet been explored.

Methods
Patients diagnosed with stage III CC from 2010 to 2016 in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved. The clinicopathological features and OS were analyzed according to the chemotherapy, PTL and histological subtype.

Results
A total of 28,765 eligible stage III CC patients were enrolled in this study. The results showed that chemotherapy, left-sided CC (LCC) and AC were favorable prognostic factors for OS. Right-sided CC (RCC) had worse OS than LCC regardless of chemotherapy. MAC had worse OS than AC in the patients with chemotherapy, but the survival benefits disappeared in the patients without chemotherapy. Additionally, in LCC, MAC had worse OS than AC regardless of chemotherapy. However, in RCC, MAC had worse OS than AC in patients with chemotherapy but had similar OS to AC in patients without chemotherapy. In the AC group, RCC had worse OS than LCC regardless of chemotherapy. In the MAC group, RCC had comparable OS to LCC regardless of chemotherapy. Four subgroups, i.e., RCC/MAC, RCC/AC, LCC/MAC and LCC/AC, all showed benefits from chemotherapy. Among them, LCC/AC had the best OS, and RCC/MAC had the worst OS compared with the other three subgroups.

Conclusion
The prognosis of MAC is worse than that of AC in stage III CC. LCC/AC has the best OS, while RCC/MAC has the worst OS but still benefits from chemotherapy. The impact of chemotherapy on survival is greater than that of histological subtype, but the impact of histological subtype on survival is similar to that of PTL.