bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between serum high-sensitivity C-reactive protein (hs-CRP) and glycated hemoglobin (HbA1c) in South Indian population
Authors: Vinod Anjana , M. Ganesh , A. Manikandan , M. Rakchna 
Published: April 2023

Introduction and Aim: Cardiovascular disease are a leading cause of death in the world. Atherosclerosis plays the most important role in its pathophysiology. It is a slowly progressing chronic inflammatory process resulting in increased levels of inflammatory markers in serum. hs-CRP is a novel biomarker of coronary heart disease risk prediction. Type 2 diabetes mellitus individuals are at an increased risk of developing cardiovascular diseases. In this study, we aim to find the association of HbA1c with hs-CRP in the South Indian population.

Materials and Methods: This was a retrospective study. The study participants were categorised into 3 groups based on their serum hs-CRP levels: Group 1 with hs-CRP < 1.0 mg/L; group 2 with hs-CRP 1.0 – 3.0 mg/L and group 3 with hs-CRP > 3.0 mg/L. The sample size was estimated to be 40 for each group. Age, fasting blood glucose, postprandial blood glucose, HbA1c, hs-CRP, total count, and ESR were collected. Statistical analyses were performed with SPSS version 16.0.

Results: Age showed no significant difference among the groups. FBS, PPBS, HbA1c, TLC, and ESR showed a significant difference among the 3 groups. TLC, FBS, PPBS, and HbA1c had a significant positive correlation with hs-CRP.

Conclusion: hs-CRP has a statistically significant positive correlation with HbA1c, fasting blood sugar, and postprandial blood sugar Additionally, we also observed that total leukocyte count had a significant positive correlation with hs-CRP and HbA1c. Hence, our results show that impaired glycemic control is associated with an increased risk of developing cardiovascular diseases.
Cytoprotective and anti-inflammatory effect of ethanolic extract of Withania somnifera root in combination with doxycycline in rotenone induced cytotoxicity in neuroblastoma cell lines
Authors: Epuri Vishala , Prathap Lavanya , Reddy Venkateshwar , B. Rajesh , B. Ramesh 
Published: April 2023

Introduction and Aim: Parkinson's disease (PD) is a neurodegenerative disorder that destroys dopaminergic neurons in the nigrostriatal area of the midbrain this results in a movement difficulty characterised by tremors, bradykinesia, and postural instability The present in vitro study is designed to assess the beneficial (cytoprotectant and anti-inflammatory) and cyto-toxicological effects of ethanolic Withania somnifera (Ashwagandha) root extract (EWSR) in presence of Rotenone (ROT) and other known neuroprotectants (Doxycycline and Ellagic acid).

Materials and Methods: The nine groups used in the in vitro studies were normal control, positive control (Rotenone or Rot), W. somnifera root extract (EWSR), Doxycycline (Doxy), Ellagic acid (EA), ROT with EWSR, ROT with doxy, ROT with EA, ROT with EWSR-doxy, and ROT with EWSR-doxy-EA. The EWSR, doxy and EA treatment was started on the 24th hour following the rotenone administration and continued for the next 36 hours. After the 36th hour of protective therapy, quantification of pro-inflammatory cytokines (ELISA), cell viability or analyses of neuronal cell loss, cell cycle analysis and molecular analysis (RTPCR) was performed as a part of assessment.

Results: Observations from the present in vitro studies clearly demonstrate the cytoprotective and anti-inflammatory properties of EWSR, and these beneficial or protective effects got enhanced when treated in combination with Doxy and EA indicating synergistic effect in the cells that were priorly treated with ROT, and later treated with EWSR, Doxy, and EA individually and in combination.

Conclusion: The findings imply that EWSR reduces the in vitro effects of ROT by acting as an anti-inflammatory and cytoprotective agent.
Sensitive and rapid Bradford and BCA protein assay by a common desktop scanner
Authors: Parween Shahila , Nahar Pradip 
Published: April 2023

Introduction and Aim: The conventional method of protein quantification involves the need for a costly spectrophotometer which is a bulky and expensive instrument. Also, it requires a considerable quantity of protein which is often valuable or not affordable. In this communication, we report a sensitive image-based protein assay method overcoming the challenges faced by the conventional method. BCA and Bradford protein assay in a miniaturized form is carried out on a polypropylene micro-test plate (PPµTP) using only 1 µl of the precious protein solution in the nanogram range without the need for expensive equipment for quantification.

Materials and Methods: In this procedure, after the assay reaction, the assay plate with a color solution is turned upside down for capturing images in a desktop scanner. The image is then quantified digitally by a color space using freely available Adobe Photoshop and Macbeth color calculator software.

Results: Standard graphs made by the present image–based method agreeably correlate with the absorbance–based method carried out in a microtiter plate with a Pearson coefficient of 0.995178 and 0.981006 for BCA and Bradford assay respectively. A test protein quantified by this method shows an accuracy of 97%. Further, we have reduced the protein assay time to 75 s only by performing the assay on PPµTP by microwave irradiation.

Conclusion: Image-based protein assay is also performed in an ultra-miniature assay plate (UAP) which requires only 1 µl of assay solution, reducing the detection limit further to the 10 femtogram/test zone. In short, image–based protein assay on PPµTP and UAP platforms could be an outstanding alternative either to spectrophotometric or paper–based protein assay.
LCM2021 – The UK Land Cover Map 2021
Authors: Marston Christopher G. , O'Neil Aneurin W. , Morton R. Daniel , Wood Claire M. , Rowland Clare S. 
Published: April 2023

Abstract. Land cover is a key environmental variable, underpinning widespread environmental research and decision-making. The UK Centre for Ecology and Hydrology (UKCEH) have provided reliable land cover information since the early 1990’s; this supports multiple scientific, government and commercial objectives. Recent advances in computation and satellite data availability have enabled annual UKCEH land cover maps since 2017. Here we introduce the latest, annual UK Land Cover Map, representing 2021 (LCM2021) and describe its production and validation. LCM2021 methods replicate those for LCM2017 to LCM2020 with minor deviations to enhance accuracy. LCM2021 is based on the classification of satellite and spatial context data into 21 land cover/habitat classes, from which a product suite is derived. The production of LCM2021 involved three highly automated key stages: pre-processing of input data, image classification and production of the final data products. Google Earth Engine scripts were used to create an input data stack of satellite and context data. A set of training areas was created, based on data harvested from historic UKCEH land cover maps. The training data were used to construct a Random Forest classifier, which yielded classified images. Compiled results were validated against 35,182 reference samples, with correspondence tables indicating variable class accuracy and an overall accuracy of 82.6 % for the 21-class data and 86.5 % at a 10 aggregated-class level. The UK Land Cover Map product suite includes a set of raster products in various projections, thematic and spatial resolutions (10 m, 25 m and 1 km) and land-parcel/vector product. The data are provided in 21-class (all configurations) and aggregated 10-class versions (1 km raster products only). All raster products are freely available for academic and non-commercial research. The data for Great Britain (GB) are provided in the British National Grid projection (https://epsg.io/27700) and the Northern Ireland (NI) data are in the TM75 Irish National Grid (https://epsg.io/29903). Information on how to access the data is given in the Data Availability section of the paper.
HUBUNGAN DUKUNGAN KELUARGA TERHADAP MOTIVASI PASIEN KANKER PAYUDARA YANG TELAH KEMOTERAPI
Authors: Titik Rusmiati  , Lisda Maria  
Published: April 2023

Latar belakang: Kanker Payudara merupakan sel ganas yang dapat membunuh wanita nomor dua di dunia. Pengobatan kemoterapi pada kanker payudara dapat menyebabkan efek samping yang buruk sehingga kepatuhan pasien menjadi rendah. Diperlukan motivasi yang tinggi untuk dapat mematuhinya. Motivasi salah satunya di dapatkan dari dukungan keluarga. Tujuan: untuk mengetahui Hubungan Dukungan Keluarga Terhadap Motivasi Pasien Kanker Payudara yang Telah kemoterapi di RS Pusri Palembang Metode: Jenis penelitian ini adalah kuantitatif observasional analitik dengan pendekatan crossectional. Populasi dalam penelitian ini adalah pasien kanker payudara yang menjalani kemoterapi di RS Pusri Palembang sebanyak 102 orang. Jumlah sampel sebanyak 50 orang. Penelitian ini dilaksanakan pada Maret - April 2022. Pengumpulan data menggunakan data primer. Analisis data menggunakan uji Spearman rank test. Hasil: Sebagian besar responden mendapatkan dukungan keluarga cukup yaitu 56 Sebagian besar responden memiliki motivasi kemoterapi cukup yaitu 82. Ada hubungan dukungan keluarga terhadap motivasi pasien kanker payudara yang telah kemoterapi di RS Pusri Palembang ( P value 0,000). Nilai Correlation Coefficient 0,591 yang berarti kekuatan hubungan sedang Kesimpulan: Ada hubungan yang sedang Antara dukungan keluarga dengan motivasi pasien kanker payudara yang kemoterapi di RS Pusri Palembang Saran: untuk mengembangkan penelitian intervensi untuk meningkatkan dukungan keluarga dalam rangka memotivasi pasien kanker dalam menjalani kemoterapi kanker payudara
HUBUNGAN HIPERTENSI DENGAN KEJADIAN PREEKLAMPSIA PADA IBU HAMIL DI RUMAH SAKIT UMUM RADEN MATTAHER
Authors: Haryanti Dwiharyanti , Rahmah Rahmah 
Published: April 2023

Preeklampsia adalah penyebab utama matinya mortilitas dan morbiditas ibu dan janin. Preeklampsia adalahsindrom yang ditandai dengan hipertensi dan proteinuria yang timbul setelah 20 minggu kehamilan.Tujuan penelitian ini adalah untuk mengetahui adanya hubunga hipertensi pada ibu hamil dengan kejadian preeclampsia diRSUD Raden Mattaher Provinsi Jambi 2018.Penelitian ini dilakukan pada tanggal 29 April 2019 di RSUD Raden Mattaher Jambi, Hasil penelitian yang telah dilakukan didapatkan bahwa ibu yang mengalami preeklampsia sebagian besar yang hipertensi (54.6%) dan sebagian kecil yang tidak tidak hipertensi yang mengalami preeklampsia (45.4 %). Hasil uji statistik chi-square diperoleh nilai p-value 0.002 ( p<0.5 ) disimpulkan bahwah terdapat hubungan hipertensi pada ibu hamil terhadap preeklampsia.
PENGARUH PIJAT OKSITOSIN TERHADAP PRODUKSI ASI PADA IBU POST PARTUMDI WILAYAH KERJA PUSKESMAS KEDURANG KABUPATEN BENGKULU SELATAN TAHUN 2019
Authors: Sari Ruri Maiseptya 
Published: April 2023

Penelitian ini berujuan untuk melihat pengaruh pijat oksitosin terhadap produksi ASI pada ibu post partum di wilayah kerja puskesmas kedurang. Penelitian ini menggunakan metode penelitian pra eksperimental dengan pendekatan bersifat Eksperimen One Group Pre-Test-Post Test. Populasi dalam penelitian ini adalah ibu hamil yang memiliki tapsiran persalinan bulan juni dan juli yang berjumlah 19 orang dengan sampel menggunakan teknik accedental sampling. Pengumpulan data dalam penelitian ini menggunakan data primer untuk melihat identitas responden dan data sekunder dengan cara melakukan pijat oksitosin pada responden. Analisis data dilakukan dengan uji shapiro-wilk dan uji paired sample t-test.hasil penelitian didapatkan : (1) dari 17 sampel terdapat 13 responden produksi ASI kurang dan 4 responden produksi ASI cukup. (2) dari 17 responden terdapat 6 orang responden produksi ASI kurang dan 11 responden produksi ASI cukup. (3) terdapat pengaruh yang signifikan antara pijat oksitosin terhadap produksi ASI pada ibu post partum di wilayah kerja puskesmas kedurang kabupaten bengkulu selatan tahun 2019. Diharapkan pihak puskesmas untuk dapat meningkatkan pengetahuan dan wawasan masyarakat khususnya tentang cara peningkatan jumlah produksi ASI pada ibu post partum dengan cara melakukan penyuluhan tentang pijat oksitosin dalam meningkatkan jumlah produksi ASI.
HUBUNGAN KEHAMILAN SEROTINUS DAN KADAR ERITROSITDENGANKEJADIAN ASFIKSIA PADA NEONATUS DI RUMAH SAKIT UMUM DAERAH RADEN MATTAHER PROVINSI JAMBI
Authors: Mariana Silvia , Riya Rosa 
Published: April 2023

Asfiksia adalah kegagalan nafas secara spontan pada saat lahir atau beberapa saat setelah lahir.serotinus adalah penyebab utama mortalitas dan morbiditas ibu dan janin.Eritrosit memiliki inti sel yang beredar di sirkulasi pada keadaan hipoksia terjadi peningkatan eritrosit berinti bebanding lurus dengan semakin beratnya hipoksia yang terjadi.
Tujuan penelitian ini adalah untuk mengetahui adanyan hubungan kehamilan serotinus dan kadar eritrosit ibu dengan kejadian asfiksia pada neonatus di RSUD Raden Mattaher Provinsi Jambi 2018.Metode Penelitian ini menggunakan desain penelitian case-control dengan pendekatan Retrospektive..
Hasil penelitian yaitu serotinus tidak beresiko dengan asfiksia (40,7%) dan serotinus beresiko kejadian asfiksia (59,3%) dengan nilai Odds Ratio53,861. eritrosit tidak beresiko dengan kejadian asfiksia (65,0%), eritrosit beresiko kejadian kejadian asfiksia (35,0% ) dimana nilai Odds Ratio.100, 161. Hasil uji chi-square di peroleh P=0,000 untuk kehamilan serotinus , P=0,000 untuk kadar eritrosit, artinya ada hubungan kehamilan serotinus dan kadar eritrosit dengan kejadian asfiksia neonatorum di rsud radden Mattaher Provinsi Jambi.

Kata Kunci :Asfiksia, Kehamilan Serotinus, kadar eritrosit
TINGKAT PENGETAHUAN MAHASISWA KESEHATAN DAN NON KESEHATAN TERHADAP PENGGUNAAN OBAT BATUK DI STIKES KELUARGA BUNDA JAMBI
Authors: Raihana Nadia , Anjelin Ririn , Nadiroh Eka Ulya , Widyanti Elisa 
Published: April 2023

Batuk merupakan upaya pertahanan paru terhadap berbagai rangsangan yang ada dan refleks fisiologis yang melindungi paru dari trauma mekanik, kimia dan suhu. Batuk merupakan gejala tersering penyakit pernapasan dan masalah yang sering kali dihadapi dokter dalam praktik sehari- hari di Indonesia. Pengobatan batuk biasanya dilakukan dengan pengobatan sendiri atau swamedikasi. Hasil suatu studi menunjukkan bahwa mahasiswa kesehatan lebih memahami tentang penggunaan obat batuk dibandingkan dengan mahasiswa non kesehatan. Oleh karena itu, penelitian ini bertujuan untuk mengetahui hubungan antara jenis pendidikan (mahasiswa kesehatan dan mahasiswa non kesehatan) dengan tingkat pengetahuan terhadap penggunaan obat batuk serta untuk mengetahui perbedaan yang signifikan antara tingkat pengetahuan mahasiswa kesehatan dengan mahasiswa non kesehatan terhadap penggunaan obat batuk di STIKes Keluarga Bunda Jambi.
Penelitian ini menggunakan metode deskriptif analitik bersifat non-eksperimental melalui penyebaran kuesioner. Penelitian dilakukan di STIKes Keluarga Bunda Jambi. Jumlah sampel yang digunakan adalah 16 responden. Hasil penelitian menunjukkan gambaran tingkat pengetahuan responden dikelompokkan menjadi 3 kategori yaitu baik, sedang, dan kurang. Usia dan jenis kelamin tidak memiliki hubungan dengan tingkat pengetahuan responden mengenai penggunaan obat batuk. Hasil yang diperoleh yaitu terdapat perbedaan signifikan antara tingkat pengetahuan mahasiswa kesehatan dengan mahasiswa non kesehatan terhadap pengetahuan penggunaan obat batuk. Dalam penelitian ini diketahui bahwa tingkat pengetahuan mahasiswa kesehatan lebih tinggi di banding mahasiswa Non kesehatan di STIKes Keluarga Bunda Jambi.
Presentasi dan Representasi: Lima Desain Sampul dari Satu Novel
Authors: Ajidarma Seno Gumira 
Published: April 2023

The novel Coming Home (Pulang) by Toha Mochtar has had five cover designs that have appeared in a span of 41 years. Chronologically, the five novels were published in 1958, 1962, 1967, 1972, and 1999. The focus of this research departs from these five cover illustrations which on one side become narrative representations in the novel. However, on the other hand it can be said to represent socio-political discourses from the era when they were composed. The method used in this study is a qualitative method through examining illustrations. To examine the illustration, representation and discourse approaches (concepts) are used. From the results of the analysis it can be seen that these historical factors and determinants can be interpreted as the cause of the differences in each cover design, and when examined chronologically, the five covers show a cultural and historical process, namely the meeting between peasant life and political history. The findings in this study also show that each cover, apart from being a narrative representation, also has its own story which can be dismantled through various critical analyses. Novel Pulang karya Toha Mochtar memiliki lima desain sampul yang muncul dalam rentang waktu 41 tahun. Secara kronologis, kelima novel tersebut terbit pada tahun 1958, 1962, 1967, 1972, dan 1999. Fokus penelitian ini bertolak dari kelima ilustrasi sampul ini yang di satu sisi menjadi representasi naratif dalam novel. Akan tetapi, di sisi lain dapat dikatakan sebagai representasi wacana sosial-politik dari zaman ketika mereka digubah. Metode yang digunakan dalam penelitian ini adalah metode kualitatif melalui pemeriksaan ilustrasi. Untuk memeriksa ilustrasi tersebut, digunakan pendekatan (konsep) representasi dan wacana. Dari hasil analisis terlihat bahwa faktor-faktor historis dan determinan tersebut dapat ditafsirkan sebagai penyebab adanya perbedaan di setiap desain sampul, dan jika diperiksaÂ dalam perbandingan secara kronologis, kelima sampul tersebut menunjukkan sebuah prosesÂ kultural dan historis, yaitu pertemuan antara kehidupan petani dan sejarah politik. Temuan dalam penelitian ini juga menunjukkan bahwa setiap sampul, selain menjadi representasi naratif, juga memiliki cerita masing-masing yang dapat dibongkar lewat berbagai analisis kritis.
It’s Complicated: Some Irregular Line-Ending Morphosyllabic Sequences in Piers Plowman B
Authors: Cornelius Ian 
Published: April 2023

ABSTRACT
Recent scholarship on the meter of fourteenth-century English alliterative verse demonstrates that lines end with a trochaic constituent. Piers Plowman is a recognized anomaly, yet there is disagreement about the extent of the differences. In this article, I examine long final dips, the vocalic quality of syllables in the final dip, and the placement of word divisions. Throughout, my focus is on the B version of the poem. I make a survey of lines with a word division after the final lift and of lines ending in -ly adverbs, compounds in -man, compounds in -nesse, nouns in -(i)oun, and gerunds. I compare the frequency of each sequence at the close of the a-verse and b-verse, observing that many individual items skew towards the norms of usage observed in other alliterative poems. Yet, more than other alliterative poets, Langland allows semantic and expository priorities to override prosodic form.
La evolución reciente de las importaciones de bienes a la luz de algunos condicionantes
Authors: García Esteban Coral , Gómez Loscos Ana , Martín Machuca César 
Published: April 2023

Motivación
Las importaciones españolas de bienes crecieron en 2022 por encima de lo que se derivaría de sus determinantes tradicionales (demanda final y competitividad-precio), por lo que resulta de interés valorar qué elementos actuaron como soporte adicional de las compras al exterior.
Ideas principales
•Las tensiones en los mercados de la energía provocadas por la invasión rusa de Ucrania impulsaron las importaciones energéticas, debido a las estrategias de almacenamiento ante eventuales problemas de suministro y de reexportación hacia otros países de la Unión Europea.
•Las importaciones de bienes cuyos procesos productivos son intensivos en el uso de energía se habrían visto impulsadas por la pérdida de competitividad de la producción interior ante el encarecimiento de las materias primas energéticas.
•El elevado dinamismo de las importaciones también se habría apoyado en la orientación de la producción industrial hacia ramas con mayor contenido importado, cuya demanda se habría incrementado por los cambios de hábitos asociados a la pandemia (p. ej., farmacéutica, informática y telecomunicaciones) y por la recuperación de la movilidad (p. ej., textil).
Enjektör ile Beslenen Prematüre Bebeklerin Annelerinin Taburculuk Sonrası Beslenmenin Devamlılığını Sağlama Durumları ve İlişkili Faktörler
Authors: GÜNER BAŞARA Sultan , BAHADIR ARSU Emel , NOĞAN Raziye 
Published: April 2023

Giriş: Prematüre bebeklerin beslenmesinde optimal bir metot tanımlamak çok zordur. Bu nedenle anne memesini emme durumuna gelene kadar emzirmeye alternatif beslenme metodu kullanılmıştır
Yöntem: Araştırma gözlemsel prospektif olarak yapılmıştır. Yenidoğan yoğun bakım ünitesinde tedavi ve bakım alan prematüre bebeğe sahip 75 anne ile yürütülmüştür. Annelere enjektörle beslenme eğitimi verilmiştir. Taburculuk sırasında ve sonrası dönemde bebeğin beslenme yöntemi ve kilosuna ait veriler anneler ile telefon görüşmesi aracılığıyla elde edilmiştir.
Bulgular: Çalışmaya katılan annelerin %68.0’ı daha önce bebek emzirme deneyimi yaşamış, %77.3’ü de bebeğini enjektör ile iyi beslendiğini ifade etmiştir. Bebeklerinin %52.0’ının 30-32. gestasyon yaşında, %74.6’sının postnatal 1-5. gün peroral beslenmeye başladıkları tespit edilmiştir. Taburculuk sonrası 7. gün beslenme yöntemleri ile kilo alımları arasında istatistiksel olarak anlamlı fark bulunmuştur (p=0.018).
Sonuç: Annelerin doğum şekli bebeklerinin besleme yöntemini etkilemektedir. Anneler 0. gün enjektör yöntemi ile beslemeyi tercih etmektedir. Gestasyon yaşı 36 hafta ve üzerinde olan prematüre bebeklerin enjektör yönteminde verilen süt veya mamayı daha iyi alabilmektedir. Kanguru bakımı alan annelerin enjektör ile beslenme yöntemini tercih edebildikleri saptanmıştır.
Intraobserver and Interobserver Reproducibility of Classifications of Tibial Plateau Fractures and the Surgical Approaches Chosen Comparing 2D CT and 3D Printing: Reliability Study
Authors: Osma-Rueda Jose , Mantilla-Angarita Fabian , Lopez-Gualdron Clara 
Published: April 2023

Introduction:
Reliability is the study of internal consistency, reproducibility (intraobserver and interobserver), and agreement. Reproducibility studies that classify tibial plateau fractures have used plain radiography and two-dimensional (2D) CT scans and three-dimensional (3D) printing. The objective of this study was to evaluate the reproducibility of the Luo Classification of tibial plateau factures and the surgical approaches chosen for these fractures based on 2D CT scans and 3D printing.

Methods:
A reliability study was performed at the Universidad Industrial de Santander, Colombia, that evaluated the reproducibility of the Luo Classification of tibial plateau fractures and the choice of surgical approaches based on 20 CT scans and 3D printing, with five evaluators.

Results:
For the trauma surgeon, reproducibility was better when evaluating the classification using 3D printing, with a kappa of 0.81 (95% confidence interval [CI], 0.75-0.93; P < 0.01) than when using CT scans, with a kappa of 0.76 (95% CI, 0.62-0.82; P < 0.01). When comparing the surgical decisions made by the fourth-year resident with those of the trauma surgeon, a fair reproducibility was obtained using CT, with a kappa of 0.34 (95% CI, 0.21-0.46; P < 0.01), which improved to substantial when using 3D printing, with a kappa of 0.63 (95% CI, 0.53-0.73; P < 0.01).

Discussion:
This study found that 3D printing provided more information than CT and decreased measurement errors, thereby improving reproducibility, as shown by the higher kappa values that were obtained.

Conclusion:
The use of 3D printing and its usefulness are helpful to decision making when providing emergency trauma services to patients with intraarticular fractures such as those of the tibial plateau.