bluuebunny/crossref_metadata_2025_split huggingface dataset:
The management of tooth wear: past, present and future
Authors: Mehta Shamir B , Banerji Subir 
Published: May 2023

Over the decades, the management of tooth wear has changed significantly. With the development in the materials available and an understanding of certain occlusal concepts, a minimally invasive strategy is now the preferred option. This article outlines these developments within an evidence-based framework. Contemporary research is referenced to support the clinical approaches to current management strategies and possible future expectations. CPD/Clinical Relevance: Knowledge of current concepts of tooth wear management in general dental practice should facilitate good treatment decisions
Safety and mortality outcomes for direct oral anticoagulants in renal transplant recipients
Authors: Firth Christine , Shamoun Fadi , Apolinario Michael , Lim Elisabeth S. , Zhang Nan , Keddis Mira T. 
Published: May 2023

Purpose
Direct oral anticoagulants (DOACs) are increasingly used in renal transplant recipients (RTR), but relatively understudied in this population. We assess the safety of post-transplant anticoagulation with DOACs compared to warfarin.

Methods
We conducted a retrospective study of RTRs at the Mayo Clinic sites (2011-present) that were anticoagulated for greater than 3 months excluding the 1st month post-transplant. The main safety outcomes were bleeding and all-cause mortality. Concomitant antiplatelet and interacting drugs were noted. DOAC dose adjustment was assessed according to common US prescribing practices, guidelines, and/or FDA labeling.

Results
The median follow-up was longer for RTRs on warfarin (1098 days [IQR 521, 1517]) than DOACs (449 days [IQR 338, 942]). Largely, there were no differences in baseline characteristics and comorbidities between RTRs on DOACs (n = 208; apixaban 91.3%, rivaroxaban 8.7%) versus warfarin (n = 320). There was no difference in post-transplant use of antiplatelets, immunosuppressants, most antifungals assessed, or amiodarone. There was no significant difference in incident major bleeding (8.4 vs. 5.3%, p = 0.89), GI bleeding (4.4% vs. 1.9%, p = 0.98), or intra-cranial hemorrhage (1.9% vs. 1.4%, p = 0.85) between warfarin and DOAC. There was no significant difference in mortality in the warfarin group compared to DOACs when adjusted for follow-up time (22.2% vs. 10.1%, p = 0.21). Rates of post-transplant venous thromboembolism, atrial fibrillation or stroke were similar between the two groups. 32% (n = 67) of patients on DOACs were dose reduced, where 51% of those reductions were warranted. 7% of patients that were not dose reduced should have been.

Conclusions
DOACs did not have inferior bleeding or mortality outcomes compared to warfarin in RTRs. There was greater use of warfarin compared to DOACs and a high rate of improper DOAC dose reduction.
Daily vs. monthly oral vitamin D3 for treatment of symptomatic vitamin D deficiency in infants: a randomized controlled trial
Authors: Gora Anupriya , Singh Preeti , Debnath Ekta , Malhotra Rajeev Kumar , Seth Anju 
Published: May 2023

Abstract

Objectives
Compare the efficacy and safety of daily vs. monthly oral vitamin D3 in treating symptomatic vitamin D deficiency in infants.

Methods
90 infants with symptomatic vitamin D deficiency were randomized into Daily (D) [46 infants] and Bolus (B) [44 infants] groups to receive oral vitamin D3, daily (2000 IU/day) and bolus (60,000 IU/month) for three months respectively. Both groups received daily oral calcium @50 mg/kg/day. Serum calcium (Ca), phosphate (P), alkaline phosphatase (ALP), 25-hydroxy cholecalciferol [25(OH)D], parathyroid hormone (PTH) levels, urine calcium: creatinine ratio and radiological score were assessed at baseline, 4 and 12 weeks. At the end of 12 weeks, 78 infants were available for evaluation of efficacy and safety of both regimens.

Results
Both regimens led to a statistically significant increase in Ca and P levels and fall in ALP and PTH levels from baseline to 4 and 12 weeks of therapy, with no inter-group difference. Infants in group D had statistically significant higher mean 25(OH)D levels as compared to group B at 4 weeks (group D 130.89 ± 43.43 nmol/L, group B – 108.25 ± 32.40 nmol/L; p – 0.012) and 12 weeks (group D – 193.69 ± 32.47 nmol/L, group B – 153.85 ± 33.60 nmol/L; p<0.001). Eight infants [group D – 6/41 (14.6 %); group B – 2/37 (5.4 %), p=0.268] developed mild asymptomatic hypercalcemia without hypercalciuria at 12 weeks that corrected spontaneously within a week.

Conclusions
Both daily and monthly oral vitamin D3 in equivalent doses are efficacious and safe for treating symptomatic vitamin D deficiency in infants.
NECAB3 promotes the migration and invasion of liver cancer cells through HIF-1α/RIT1 signaling pathway
Authors: Tian Yicheng , Shao Longjiang , Wang Qi , Ru Gan , Zhai Chuntao , Zhou Lihui 
Published: May 2023

Abstract
Liver cancer is a prevalent malignant tumor with high mortality worldwide, making it urgent to explore new targets for liver cancer therapy. N-terminal EF-hand calcium binding protein 3 (NECAB3) is a new recognized regulator of cancer, while its role in liver cancer remained elusive. Thus, the study clarified the action of NECAB3 on liver cancer development and explored the detailed mechanism. We found that NECAB3 was enhanced in liver cancer. Knockdown of NECAB3 restrained liver cancer cell migration and invasion. Besides, knockdown of NECAB3 suppressed the activation of the hypoxia-inducible factor 1-alpha (HIF-1α)/Ras like without CAAX 1 (RIT1) pathway. Furthermore, NECAB3 regulated liver cancer migration and invasion through modulating RIT1 expression. Moreover, downregulation of NECAB3 suppressed liver cancer tumor growth in vivo. In conclusion, NECAB3 was upregulated in liver cancer. Knockdown of NECAB3 suppressed aggressive phenotype of liver cancer via modulating the HIF-1α/RIT1 axis, providing a possible target for liver cancer therapy.
Schleiermachers Kritik an der Hamartiologie Augustins
Authors: Zhou Xiaolong 
Published: May 2023

Zusammenfassung
Schleiermachers Theorie der Erbsünde wird gewöhnlich als Abkehr von Augustinus verstanden. Diese Behauptung ist unhaltbar. Eine genauere Untersuchung wird zeigen, dass Schleiermachers Kritik an Augustinus darauf abzielt, Augustins Lehre von der Erbsünde logisch kohärent und widerspruchsfrei zu machen und die Gefahr eines manichäischen Dualismus so weit wie möglich zu umgehen. Darüber hinaus wird gezeigt, dass Schleiermachers Lehre von der Erbsünde in hohem Maße kohärent und in sich konsistent ist, da die folgenden Ideen Schleiermachers philosophische und theologische Schriften durchdringen: die Untrennbarkeit der transzendentalen Freiheit von den sinnlichen Trieben, die Untrennbarkeit von Materie und Form und die Untrennbarkeit von Gott und Welt. Auf diese Weise können wir den Geist von Schleiermachers Lehre der Erbsünde besser verstehen.
The efficacy of gemcitabine combined with immunotherapy in a patient with metastatic metaplastic squamous cell carcinoma of the breast
Authors: Liu Qi , Ji Kailun , Li Longlong , Wang Xiaolin , Sun Zheng , Xu Chunhong 
Published: May 2023

Abstract

Objectives
Metaplastic squamous cell carcinoma of the breast is a rare form of breast carcinoma for which there is currently no standard treatment.

Case presentation
We report the case of a 33-year-old woman with enlargement in her left breast who was diagnosed with metaplastic squamous cell carcinoma by core needle biopsy. The patient underwent a modified radical mastectomy. The immunohistochemistry showed it was a triple-negative breast cancer: progesterone receptor-negative (PR-), estrogen receptor-negative (ER-), and human epidermal growth factor receptor 2 -negative (HER2-). The patient received 6 cycles of adjuvant chemotherapy with nab-paclitaxel and carboplatin. One year later, she developed lung metastases from squamous cell carcinoma. Immunohistochemical results remained triple-negative (ER-, PR- and HER2-). The patient then received gemcitabine combined with immunotherapy. The patient has been assessed as stable disease so far.

Conclusions
Immunotherapy combined with gemcitabine showed good efficacy in the treatment of metastatic metaplastic squamous cell carcinoma of the breast after nab-paclitaxel combined with platinum-based therapy.
Perfil socio familiar y cognición social de un grupo de actores de acoso escolar en una institución educativa del departamento del Quindío - Colombia
Authors: Gonzales Portillo Juan , Arbeláez Caro Joan Sebastián , Gutiérrez Camacho Stephania , Ortega Cubillos Sandra Lorena 
Published: May 2023

Objetivo: Comparar los perfiles de dinámica familiar y de cognición social en los diferentes niveles de riesgo (víctimas y acosadores) acoso escolar en adolescentes del departamento del Quindío. Materiales y Métodos: La investigación siguió un diseño cuantitativo con un enfoque descriptivo de alcance comparativo. Se contó con la participación de 50 adolescentes de una institución educativa de la ciudad de Armenia, Quindío. Resultados: Los principales hallazgos de este estudio fueron en primer lugar que no hay diferencias en dinámica familiar o teoría de la mente entre las víctimas (F(1) = 0,51; p = 0.60), además existen diferencias en la teoría de la mente de los intimidadores (F(1) = 5.16; p = 0.00). Conclusiones: Tanto la dinámica familiar como la teoría de la mente tiene relación con en el riesgo de ser víctima o intimidador de acoso escolar.
Der Aufbau des Bibliothekssystems im Königreich Ungarn und im Großfürstentum Siebenbürgen im neuen Reichsrahmen (1686/1690–1815)
Authors: Monok István 
Published: May 2023

AbstractThe Kingdom of Hungary and the Grand Duchy of Transylvania were integrated into the Holy Roman Empire during the 18th century and accordingly, this shaped its institutional system. There were many obstacles to the creation of the “Empire-conform” library system. After 150 years of Ottoman rule, the country had to be rebuilt physically. It also had to build new Church and state centers, while the wars against the Turks continued, until the end of the 18th century. Public life was burdened by the anti-Protestantism of the Habsburg emperors, since, at the end of the 17th century, two-thirds of the country's population were Protestants. By the end of the 18th century this proportion had dropped to one-third. (At the same time, the Protestant institutional system was also dismantled.) In other words, the library system was built twice in a century and a half and demolished again to create a new system. In summary, however, it can be concluded that a library system conforming to that of the Habsburg Empire was established in the Kingdom of Hungary and Transylvania during the century following the end of the Ottoman rule.
Gambling advertising on Twitter before, during and after the initial Australian COVID-19 lockdown
Authors: Russell Alex M.T. , Hing Nerilee , Bryden Gabrielle Maria , Thorne Hannah , Rockloff Matthew J , Browne Matthew 
Published: May 2023

AbstractBackground and aimsCOVID-19 resulted in the shutdown of almost all sporting competitions and most venue-based gambling opportunities. This study examines how wagering operators in Australia responded, by examining their advertising.MethodsThe study compared Twitter activity during lockdown (March–May 2020) to the previous year for four major wagering operators.ResultsWagering operators continued to advertise in earnest, changing their marketing mix to include more race betting content, as races continued to operate. Most also promoted the only sports available, such as table tennis or esports. When sports resumed, sports betting advertising quickly returned to normal, or exceeded previous levels. Despite more content being available in the case of two operators, engagement from the public during lockdown was similar to or lower than previously.Discussion and conclusionThese results indicate that gambling operators can adjust quickly to major changes. These shifts appear to have been successful, with the increase in race betting during this period almost completely offsetting the decreases in sports betting. This is likely due in part to changes in advertising, which have been associated with increased betting activity, particularly amongst vulnerable people. Responsible gambling messages were virtually non-existent on Twitter, which contrasts with mandatory requirements in other media. The study highlights that regulatory changes to advertising, e.g., banning some content, are likely to be met with substitution of content, rather than reduction, unless advertising volume is also capped. The study also highlights the adaptive capacity of the gambling industry in the face of major disruption to supply.
Modulation of photoluminescence and optical limiting properties of spray-coated tin oxide thin film through Eu doping
Authors: Hind P. Asha , Patil Parutagouda Shankaragouda , Gummagol Neelamma B. , Goutam U. K. , Rajendra B. V. 
Published: May 2023

AbstractThis work reports the effect of Eu doping on the structural, morphological, linear, and nonlinear optical properties of Sn1−xEuxO2 (x = 0 to 0.10) thin films prepared using spray pyrolysis. The films crystallized in tetragonal structure and the crystallite size reduced due to Eu incorporation. The film morphology consisted of evenly distributed dense grains with trapezohedron or bipyramidal shape. The Eu doping reduced the transmittance and energy band gap of the deposited films. The photoluminescence (PL) emission spectra comprised the contributions from both the transitions related to the Eu3+ ions and the defects, such as oxygen vacancies and tin interstitials in the host lattice. The films also showed a near white light emission due to the different defect-related PL emissions. The Z-scan technique revealed the third-order optical nonlinearity shown by the films. Amongst the doped films, Sn0.92Eu0.08O2 films exhibited least optical limiting threshold.
Graphical abstract
URGENSI PENYESUAIAN METODE PEMBELAJARAN DI ERA DISRUPTIVE TECHNOLOGY
Authors: DJAENUDIN ASEP 
Published: May 2023

Seorang guru profesional di era milenial atau Generasi Y, tidak cukup hanya menguasai empat kompetensi guru, yakni kompetensi pedagogik, kepribadian, profesional, dan sosial. Perkembangan teknologi informasi yang begitu pesat, mengharuskan seorang guru menjadi bagian dari kemajuan teknologi itu sendiri. Jika mereka lahir pada Generasi X atau genereasi tradisional, maka mereka harus mengejar ketertinggalan itu dengan belajar berbagai aplikasi teknologi kekinian. Jika tidak, maka mereka hanya akan menjadi guru yang pandai menceritakan masa lalu belaka, padahal masa lalu sudah lama ditinggalkan. Mendikbud, Prof. Muhajir Effendi menambahkan guru profesional di zaman milenial harus memenuhi kompetensi inti (expertise), tanggung jawab social (responsibility), dan kesejawatan (esprit de corps). Di sinilah urgensinya guru menyesuaikan metode pembelajaran di era disruptive technology.A professional teacher in the millennial era or Generation Y, it is not enough to only master the four teacher competencies, namely pedagogic, personality, professional, and social competencies. The development of information technology is so rapid, requires a teacher to be part of the advancement of technology itself. If they were born in Generation X or the traditional generation,then they must catch up by learning various applications of contemporary technology. If not, then they will only become teachers who are good at telling the past, even though the past has long been abandoned. Minister of Education, Prof. Muhajir Effendi added that professional teachers in the millennial era must meet core competencies (expertise), social responsibility (responsibility), and peer relations (esprit de corps). This is where the urgency for teachers to adapt learning methods in the era of disruptive technology.
Dowel behaviour of rebars under combined axial and shear actions
Authors: Preti M. , Paderno A. , Cominoli L. 
Published: May 2023

AbstractThe resource of shear resistance provided by the dowel mechanism of rebar in reinforced concrete (RC) structures can significantly affected by the simultaneous presence of axial loading. This occurs for example of plastic hinges of seismic resistant structures. In fact, at load reversals in cycles of large deformation demand, rebars are subjected to combined axial and shear loading, particularly in those section where the shear transfer via aggregate interlocking is jeopardized by the opening of the crack throughout the entire section depth. Thus, a reliable assessment of the shear capacity of dowels under combined shear and axial load is required to check the element shear resistance. The paper describes the results of a specific experimental campaign on rebar dowels subjected to shear loading in presence of different levels of axial load. Both smooth and ribbed rebar dowels were investigated. A marked reduction of the dowel shear strength and stiffness in presence of increasing axial loading was experimentally observed, only partially compensated by the kinking effect. The latter was found to characterize the entire resource of dowel capacity when the axial load was close to the rebar yielding strength. The paper proposes an analytical model, adapted from others available in the literature, to predict the dowel shear-displacement response accounting for the applied axial load. The model helps the understanding of the dowel response, is suitable for hand calculation and can easily assist the dowel design. The experimental response was quite well captured for smooth dowels, while the prediction was less accurate for ribbed ones. Future refinements may address the local damage induce by the rebar pull-out, typical of ribbed rebars, which is neglected in present form of the model.
OPTIMIZATION OF OPERATING PARAMETERS OF OPEN COOLING TOWERS OF THE DOUBLE-CIRCUIT COOLING SYSTEM
Authors: Ivanyakov S. V. , Kryuchkov D. A. 
Published: May 2023

The operation of most chemical processes is accompanied by the cooling of various production streams over a wide temperature range using various refrigerants. At cooling temperatures of process streams up to 25 °C, the most common refrigerant is water prepared in circulating water supply systems of petrochemical plants equipped with fan cooling towers, the work of which is considered in the article. Operation of open cooling towers in single-circuit cooling systems is characterized by high economic efficiency with a wide range of thermal capacities. However, drip entrainment of circulating water, entry of production products into the atmosphere, enrichment of circulating water with oxygen followed by growth of microorganisms in water requires a transition to two-circuit systems in which cooling is carried out by a closed-cycle refrigerant cooled by open-cycle water passing through cooling towers. But such changes in cooling systems reduce the economic efficiency of these systems. The analysis of the equipment operation in the open and closed circuits of the cooling system, provided that a number of system parameters are constant (heat load, quality of purification of recuperation heat exchangers of the cooling system, etc.), made it possible to formulate optimization (minimization) of operating costs for water cooling. Taking into account the previously obtained models of pollution growth in recuperation heat exchangers and considering the vector of control parameters of the optimization problem, the main parameter of optimization (mimimization) of operating costs for cooling, which is the cooling temperature of cooling water, was identified. The results of the analysis of the influence of ambient air parameters on the temperature of the produced cooling water in the open cooling towers are also presented, and the calculation of the economic efficiency of the cooling system operation is carried out taking into account seasonal changes in ambient air parameters.
Pavonia paludicola (Malvaceae), a new record for Mexico
Authors: Carnevali Fernández-Concha Germán , Tapia-Muñoz José Luis , Ramírez-Morillo Ivón M. , Duno-de Stefano Rodrigo 
Published: May 2023

Background: Pavonia (Malvaceae) is a morphologically diverse genus with more than 200 species in America of which 32 have been previously reported in Mexico. In a field trip to the Reserva Estatal de Dzilam de Bravo, in northern Yucatan, a population of a Malvaceae species was detected that could not be unequivocally matched with any species known previously in the country.
Questions: What is the identity of the Malvaceae species collected? Is it a taxonomic national or regional novelty?
Species of study: Malvaceae, Malvoideae, Pavonia.
Study site and dates: Yucatan Peninsula, Mexico, 2021–2022.
Methods: Botanical specimens were collected and determined taxonomically through the use of specialized keys, and consulting of botanical collections. The conservation status was assessed using the IUCN methodology.
Results: The specimens collected at the study site do not represent an undescribed species but instead Pavonia paludicola Nicolson ex Fryxell, which is a new record for Mexico. The species is assessed as Least Concern (LC) along its full distributional range whereas the Yucatan population is assessed as Data Deficient (DD) at this time. Furthermore, we offer a key to the two species of Pavonia in the Mexican portion of the Yucatan Peninsula, the second being P. schiedeana Steud., whose conservation status is assessed as Least concerned (LC).
Conclusion: With the report of Pavonia paludicola, thirty-three species of the genus are now recognized from Mexico, two of which occur in the Mexican portion of the Yucatan Peninsula.
Ten studies on Translation of 19th Century Spain
Authors: Marín Zuluaga Olga Elena 
Published: May 2023

[TEXT IN SPANISH]
Book reviewed:
Zaro, Juan Jesús (Ed.) (2008). Diez estudios sobre la traducción en la España del siglo xix. Granada:Atrio, Colección Traducción en el Atrio, 271p. ISBN: 978-84-96101-63-0
АНАЛІЗ ЗАСТОСУВАННЯ ІСНУЮЧИХ ТЕХНІК РОЗПІЗНАВАННЯ ФЕЙКОВИХ НОВИН ДЛЯ ПРОТИДІЇ ІНФОРМАЦІЙНІЙ ПРОПАГАНДІ
Authors: Штефанюк Євгеній Федорович , Опірський Іван Романович , Гарасимчук Олег Ігорович 
Published: May 2023

Проблема виявлення неправдивої (фейкової) інформації, що передається через різні канали в мережі Інтернет стає все більш актуальною. Одним з різновидів такої інформації є цільова пропаганда, яка має конкретну мету та використовує спеціально створені ресурси. Для боротьби з таким інформаційним впливом можна використовувати вже розроблені засоби виявлення фейкових новин. В цій статті розглянуто особливості інформаційної пропаганди та підходів до боротьби з нею; ефективність роботи декількох відомих технік розпізнавання фейкових новин; проведено аналіз ефективності цих технік в контексті можливості їхнього застосування для протидії цілеспрямованим інформаційним впливам. На основі проведеного дослідження обрано найбільш перспективний алгоритм для розпізнавання інформаційної пропаганди в соціальних мережах.