bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nature-inspired biomolecular corona-based on poly(caffeic acid) as a low potential and time-stable glucose biosensor
Authors: Kuznowicz Maria , Jędrzak Artur , Jesionowski Teofil 
Published: August 2023

Abstract
Herein, we present novel biosensor based on nature-inspired poly(caffeic acid) (PCA) grafted to magnetite (Fe3O4) nanoparticles with glucose oxidase (GOx) from Aspergillus niger via adsorption technique. The biomolecular corona was applied to fabrication of biosensor system with screen printed electrode (SPE). The obtained results indicated an operation of the system at low potential (0.1 V).
Then, amperometric measurements were performed to optimize conditions like various pH and temperatures. The SPE/Fe3O4@PCA-GOx biosensor presented a linear range from 0.05 mM to 25.0 mM, with a sensitivity of 1198.0 μA mM−1 cm−2 and a limit of detection 5.23 μM, which was compared to other biosensors presented in the literature. The proposed system was selective towards various interferents (maltose, saccharose, fructose, L-cysteine, uric acid, dopamine and ascorbic acid) and shows high recovery in relation to tests on real samples, up to 10 months of work stability.
Moreover, the Fe3O4@PCA-GOx biomolecular corona has been characterized using various techniques such as Fourier transform infrared spectroscopy (FTIR), high-resolution transmission electron microscopy (HRTEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and Bradford assay.
Demonstration of a Terahertz Coplanar-Strip Spoof-Surface-Plasmon Polariton Low Pass Filter
Authors: Haghighat Mohsen , Darcie Thomas , Smith Levi 
Published: August 2023

Abstract
There is a growing interest in Spoof Surface Plasmon Polariton (SSPP) structures at Terahertz (THz) frequencies for applications such as filtering, sensing, and communications. However, to date, there are limited experiments which confirm SSPP characteristics at THz frequencies. The majority of literature focuses on simulation or verification by device scaling down to Gigahertz (GHz) frequencies where standard vector network analyzers are readily available. This paper presents the first experimental verification of SSPP characteristics at THz frequencies in a guided wave system useing coplanar strip (CPS) feedlines. Specifically, we design three SSPP structures with varying band-edge frequencies (1.04 THz, 0.63 THz, and 0.53 THz), then fabricate and verify the low-pass transmission characteristics using a modified THz-time-domain spectrometer (THz-TDS) system. We find strong agreement between simulation, theory, and experiment.
A radiomics based method for prediction of prostate cancer Gleason score using enlarged region of interest
Authors: Zhuang Haoming , Chatterjee Aritrick , Fan Xiaobing , Qi Shouliang , Qian Wei , He Dianning 
Published: August 2023

Abstract
Background
Prostate cancer (PCa) is one of the most common cancers in men worldwide, and its timely diagnosis and treatment are becoming increasingly important. MRI is in increasing use to diagnose cancer and to distinguish between non-clinically significant and clinically significant PCa, leading to more precise diagnosis and treatment. The purpose of this study is to present a radiomics-based method for determining the Gleason score (GS) for PCa using tumour heterogeneity on multiparametric MRI (mp-MRI).
Methods
Twenty-six patients with biopsy-proven PCa were included in this study. The quantitative T2 values, apparent diffusion coefficient (ADC) and signal enhancement rates (α) were calculated using multi-echo T2 images, diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MRI (DCE-MRI), for the annotated region of interests (ROI). Then texture feature analysis, ROI range expansion and feature filtering was performed. Then obtained data were put into support vector machine (SVM), K-Nearest Neighbor (KNN) and other classifiers for binary classification.
Results
The highest classification accuracy was 73.50% for distinguishing between clinically significant (Gleason 3 + 4 and above) and non-significant cancers (Gleason 3 + 3) and 81.50% for distinguishing between Gleason 3 + 4 from Gleason 4 + 3 and above, which was achieved using the SVM model and initial ROIs drawn by the radiologists. The accuracy improved when using expanded ROIs to 77.78% using SVM and 85.71% using Bayesian classification for distinguishing between clinically significant and non-significant cancers and Gleason 3 + 4 from Gleason 4 + 3 and above, respectively.
Conclusions
The classification results indicate the research significance and value of this study for determining the GS for prostate cancer using the expansion of the ROI region.
Satisfaction and use of the Didactic simulator for learning the nursing process: An observational study
Authors: Barrientos Alberto Cruz , Calvo Eva Manuela Cotobal , Otero Ana Sáinz , Rodríguez José Manuel de la Fuente , Sánchez Daniel Román , Barrientos Inés Carmona 
Published: August 2023

Abstract
Introdution: The implementation of ICTs in daily healthcare practice has become standardized. In relation to education within the nursing degree, ICTs make it possible to carry out practical immersion training from the classroom or from any other place with an Internet connection, as evidenced by circumstances that have occurred in recent years, such as the pandemic caused by COVID-19. Objective: To develop a didactic simulation program for the training of the nursing process that promotes learning in the nursing care process. Methodology: The methodological approach is quantitative and it is a descriptive cross-sectional study. The sampling method used was non-probabilistic by convenience. Results: When observing the comparison of the averages of student satisfaction with respect to the didactic simulator, it is worth mentioning that all the items are above 2.80 on a score in which "0" is the minimum value and "5" the maximum value. The results of the use of the computer tool by the students, we highlight as significant data that all the items present an average equal to or lower than 3.04 out of 7, where "1" corresponds to a lot of use and "7" to little use. Conclusion: The implication of ICT in the teaching-learning process among Nursing Degree students, it is considered optimal. when analyzing the answers obtained in the items that refer to a higher ease in the execution of development of Care plans, a fundamental work in Nursing performance.
The sensitivity of climate and climate change to the efficiency of atmospheric heat transport
Authors: Ge Qi , Zheng Zhihua , Kang Litai , Donohoe Aaron , Armour Kyle , Roe Gerard 
Published: August 2023

Abstract
Atmospheric heat transport (AHT) moderates spatial gradients in surface temperature, and its efficiency (hereinafter referred to as diffusivity) shapes the distribution of moist static energy and the hydrological cycle. Using a linear downgradient rule for AHT, we diagnose zonalmean diffusivity using observational and model data. We find it varies two- to three-fold with season and latitude, but is nearly invariant across different climate states. We then employ a moist energy balance model (MEBM) to explore the impacts of changing the magnitude and spatial pattern of diffusivity on the climatology and climate response to forcing. Spatial anomalies in diffusivity in the extra-tropics have a larger impact on temperature and hydrology than diffusivity anomalies in the tropics. We demonstrate that compensating dynamical adjustments in the MEBM act to mute the impact of changing diffusivity patterns on the resulting climate. We isolate the impacts of spatial patterns of forcing, ocean heat uptake, radiative feedbacks, and diffusivity on the spatial pattern of climate change; and find that the pattern of climate change is least sensitive to the detailed pattern of diffusivity. Overall, these results suggest that although diffusivity is far from spatially invariant, understanding the climatology and spatial patterns of climate change does not depend of a detailed characterization of the spatial pattern of diffusivity.
WITHDRAWN: Phenological stages of growth in grapevine (Vitis vinifera L.) via codes and details as per BBCH scale
Authors: Manzoor Ikra , Sultan Rania Mohammad Sabri , Kumar Pravin , Abidi Ishfaq. A. , Nisa Bismat un , Bhat K. M. , Mir M. A. , Lone Showkat A , Iesa Mohamed A. M. , Tarique Mohammed , Nazim Naveena , Dar Showket Ahmad , Youssef Rawa 
Published: August 2023

Abstract

Background
Considering the phenological aspects, Vitis vinifera has peculiar position in the plant kingdom exhibiting various phenophases from dormancy until senescence viz., budburst, bloom, berry-set, ripening and harvesting. Just like other systems of agriculture and horticulture, grape orchardists and scientists require various types of scales which are convenient, globally accepted, error-free and reliable to study its growth and development.
Materials and methods
In this study, the details of specific phenological stages of grapevine were measured with the help of Biologische Bundesanstalt, Bundessortenamt, und Chemische Industrie (BBCH) scale. The BBCH-scale employs decimal coding with additional drawings into it for defining the phenology of grapevine with first digit showing principal growth stage of growth and the second digit the secondary stage of growth corresponding to ordinal number or percentage value.
Results
In this study, the phenological stages of growth in grapevine covering the entire cycle of growth, from with sprouting and ending upon senescence were identified and discussed. The stages are divisible into seven principal growth stages; two representing vegetative phase (sprouting (0) and leaf development (1)) and four stages describing reproductive growth (inflorescence emergence (5), flowering (6), development of fruits (7), ripening of berries (8)) and last stage is for senescence (9) as per BBCH scale. In the principal stages of growth a total of 17 secondary stages of growth
Conclusion
The phonological growth stages of grapevine have been detailed as per BBCH scale via codings distinguishing its vegetative and reproductive cycle.
Clinical Efficacy of Intelligent Optimal Pulse Technology in the Treatment of Evaporative Dry Eye
Authors: Xia Jia-yi , Liu Yi , Fang Yu-ting , Zhu Sheng-yu , Ji Hua-ying 
Published: August 2023

Abstract
AIM: To evaluate the efficacy and safety
of intense pulsed light (IPL) therapy with intelligent optimal
pulse technology (IOPT) in the treatment of evaporative dry eye
(EDE).
METHOD: A total of 84 eyes from 42
patients with EDE were enrolled to receive either three sessions of
IOPT combined with meibomian gland expression (MGX) or MGX-alone
treatment sessions at 3-week intervals. The ocular surface disease
index(OSDI) score, tear meniscus height(TMH), fluorescein break-up
time of the tear film(FBUT), corneal fluorescein staining(CFS)
score, Schirmer I test(SIT), tear film lipid layer grade(TFLL), lid
margin abnormality score(LAS), and assessment of 15 meibomian
glands in each of the upper and lower eyelids, including meibomian
gland expressibility(MGE), total meibomian gland secretion
quality(TMGS), and meibomian gland dropout rate(MGDR), were
evaluated at various time points, including day(D)0, D21, D42, D63,
and the 3-month follow-up visit after treatment(3 M). Safety
outcome measures were comprised of best-corrected visual acuity
(BCVA), intraocular pressure (IOP), eye structure damage under slit
lamp biomicroscopy, and facial skin appearance at each visit.
RESULT: The OSDI score, CFS, TFLL, LAS,
TMGS, and MGE showed a statistically significant greater
improvement in the treatment group after three courses of treatment
compared with those in the control group (all p<0.05). While
these improved in both groups in comparison to baseline (D0), the
eyelid MGDR was significantly improved only in the treatment group
(P<0.05). At the 3-month follow-up after treatment (3 M), only
the OSDI score, FBUT, upper eyelid MGE, TMGS and eyelid MGDR were
statistically significant, while there was no significant
difference in the control group compared to baseline (D0).
CONCLUSION: IOPT is a safe and effective
treatment for EDE. It is more effective than MGX alone in improving
symptoms, reducing ocular surface inflammation, and improving
meibomian gland structure and function.
Clinical trial registry
number(TRN): KY2023227;
(Date:14/06/2023)
Trends in Israeli Community-Based Opioid Prescribing, 2010-2020, an Observational Study
Authors: Dressler Reuven L. , Kaliner Ehud , Cohen Matan J 
Published: August 2023

Abstract
Background - Prescription opioids are widely used for pain control and palliative care but have been associated with a variety of untoward effects, including opioid use disorder, addiction, and increased mortality. Patterns of opioid use in Israel are to date poorly described. Methods - Using a representative community-based sample, the authors performed a retrospective analysis of filled opioid prescriptions of Israeli HMO members 18 years of age or older during the years of 2010–2020 that filled at least one opioid prescription. Morphine milligram equivalent (MME) calculations were stratified by presence or absence of oncology diagnosis and by specific opioid medication. Results - The percentage of HMO members who filled at least one opioid prescription increased every year from 2.1% in 2010 to 4.2% in 2020. There was an increase in the MME per prescription (44.2%), daily MME per capita (142.1%) and MME per prescription-filling patient (39%) from 2010 to 2020. Increased prescription opioid use is driven by a small group of patients, which is less than 1.5% of opioid-prescribed patients and 0.1% of the adult population, primarily owing to fentanyl use. Conclusion - Curbing prescription opioid use in Israel should be a focused directed effort rather than an overreaching intervention, complemented by improved physician training and access to non-opioid therapies, as well as improved data collection and analysis.
The value of combined detailed first- trimester ultrasound– biochemical analysis for screening fetal aneuploidy in the era of non-invasive prenatal testing
Authors: Ye Caixia , Duan Hongyan , Liu Mengyuan , Liu Jianqiang , Xiang Jingwen , Yin Yizhen , Zhou Qiong , Yang Dan , Yan Ruiling , Li Ruiman 
Published: August 2023

Abstract
Purpose
This study aimed to investigate the performance, cost-effectiveness and additional findings of combined detailed ultrasound and biochemical screening for risks of major fetal trisomies in the first- trimester.
Methods
This is a retrospective analysis study, we estimated the risk of trisomies 21, 18 and 13 based on maternal age, fetal nuchal translucency thickness, nasal bone, ductus venosus pulsatility index velocity, tricuspid regurgitation, fetal heart rate, free beta-human chorionic gonadotropin, and pregnancy-associated plasma protein A in singleton pregnant women, and performed non-invasive prenatal testing for women with risks of trisomy 21 between 1:500 and 1:300. Invasive diagnostic testing was performed for women with positive or failed non-invasive prenatal testing result and in the high-risk group of this screening method. The direct costs were compared between this strategy and the non-invasive prenatal testing which alone used as first-line screening for all pregnant women.
Results
Among 25,155 singleton pregnant women who underwent screening, 24,361 were available for analysis, of these, 194 cases underwent non-invasive prenatal testing. Among the 24,361 women, 39, 19, and 7 had trisomies 21, 18 and 13, respectively. The use of this strategy could potentially detect approximately 94.87% of trisomy 21 cases, 100% of trisomy 18 cases, and 100% of trisomy 13 cases, with false-positive rates of 2.49%, 0.41%, and 0.49%, respectively. The overall detection rate and overall false-positive rates were 96.92% and 2.52%, respectively. The detection rate was 100% in the advanced age group and 94.12% in the general age group. Additionally, structural abnormalities were detected in 137 fetuses, and 44 fetuses had other chromosomal abnormalities. The total cost of this strategy was $3,730,843.30, and the cost per person tested was $153.15. The total cost of using non-invasive prenatal testing as the first-line strategy would be $6,813,387.04 and the cost per person tested was $279.68.
Conclusions
Our strategy is an efficient and cost-effective approach for detecting major trisomies and identifying more fetuses with a potential abnormality. Therefore, this strategy is a valuable screening method and highly feasible in the clinical setting.
The combined application of frailty index and prognostic nutritional index for short-term prognosis after colorectal surgery
Authors: Huang Lihong , Jian Mengru , Song Shixi , LI Zhifa , Wu Xiaobing , Chen Huixian , Qin Haifeng , Li Ziqiao , Chen Rong 
Published: August 2023

Abstract
objective
Cooperative physiological reserve function is closely related to postoperative mortality and adverse outcome. Elderly patients with colorectal cancer should be performed preoperative geriatric assessment (CG). To construct a PNI-MFI-5 score system based on prognostic nutrition index (PNI) and modified debilitation index (MFI-5), to evaluate the elderly before operation and to explore the value of predicting poor prognosis after colorectal cancer operation.
Methods
213 elderly patients who underwent radical resection of colorectal cancer were selected. The critical values of IPN and MFI-5 and their correlation were determined by receiver operating characteristic (ROC) curve, and the relationship between PNI-MFI-5 score and clinical parameters of colorectal cancer was analyzed. COX regression model was used to determine the relationship between PNI-MFI-5 score and postoperative poor prognosis, and ROC curve was used to determine the predictive efficiency of PNI-MFI-5.
Results
There was a significant correlation between preoperative PNI and preoperative MFI-5 score (r = -0.14, p < 0.05). The PNI-MFI scores increased significantly in advanced age (P < 0.003), ASA grade 3–4 (p < 0.001), preoperative anemia (p < 0.001), preoperative hypoproteinemia (p < 0.001) and tumor diameter ≥ 5cm (p < 0.001). A total of 73 patients had adverse outcome events, of which postoperative hypoproteinemia accounted for the highest proportion, followed by pulmonary infection. With each increase of grade, postoperative pulmonary infection (OR = 2.374,p < 0.001), anastomotic leakage (OR = 2.390,p < 0.001), septicemia (OR = 4.198,p < 0.001), hypoproteinemia (OR = 3.075, p < 0.001), cardio-cerebrovascular accident (OR = 3.742) occurred. The risk of postoperative adverse outcome events such as death at 30 days after operation (OR = 4.198,p < 0.05) increased. Further univariate and multivariate analysis showed that only PNI-MFI-5 score (OR = 2.540,95%CI 1.498–4.307 score pendant 0.001) was an independent predictor of adverse outcome events after CRC. The prediction efficiency of PNI-MFI-5 was higher, and the area under the curve of PNI-MFI-5 score (AUC = 0.724,P < 0.001) was larger than that of MFI-5 score (AUC = 0.678,95%CI 0.602–0.753 (P < 0.001) and PNI (AUC = 0.667,95%CI 0.585–0.748, P༜0.001).
Conclusion
The perioperative risk model of IPN-MFI-5 score system was constructed to accurately predict the risk of postoperative adverse outcome in patients with colorectal cancer.
Sonic-induced cellular vibrations disrupt poricidal cone trichomes to boost tomato floral pollination
Authors: CAZZONELLI CHRISTOPHER , Anwar Sidra , Dingley Angus , Vinoth Thailammai , Liang Weiguang , Sindel Brian , George Laurel , Wang Chun , Happy Happy 
Published: August 2023

Abstract
Artificial pollination methods rely primarily on air-jets, vibrating wands and trellis tapping which can spread pathogens. This problem can be addressed by non-contact sonic techniques that vibrate cells via sound waves yet how frequency and intensity affect pollination, seed set and fruit size remain unclear. Our study systematic characterizes frequency-dependent vibration events on greenhouse-grown tomato flowers comparing them with contact-induced oscillations from a vibrating wand and a mechanical shaker arm. Sonic vibrations in the frequency range from 50 to 10,000 Hz increased pollination, fruit size, weight, and seed set in Sweetelle and Endeavour commercial varieties. Scanning electron microscopy revealed sonication loosened the trichomes joining the poricidal cone lobes that encase the anthers filled with pollen. Ultra-sonic frequencies enlarged fruit size, whereas seed set remained constant thereby challenging the floral cells power-law rheological characteristics in different frequency scales. Our bioacoustics non-contact precision technology can be used to boost tomato floral self-pollination.
Teaser
Leveraging bioacoustics from bees and bats to boost precision pollination of tomato flowers and fruit size in commercial varieties
A Nomogram for stratifying the malignancy risk for BI- RADS 4 breast masses detected on supplemental ultrasound in dense breast women
Authors: Li Cheng , Luo Yong , Jiang Yan , Wu Xumiao , Li Qi 
Published: August 2023

Abstract
Supplemental ultrasound is an effective way to increase the sensitivity of screening mammography for detecting breast cancer in women with dense breasts. However, due to its low positive predictive value (PPV), it often results in numerous unnecessary biopsies. This study aims to develop a predictive model that can stratify the malignancy risk of BI-RADS category 4 breast masses, which are identified additionally through supplemental ultrasound after screening mammography in women with dense breasts. After applying inclusion/exclusion procedures, a total of 425 eligible masses were selected from our institutional medical database. These masses were then divided into a training set (n=298) for model construction and a validation set (n=127) for model validation. A logistic regression model including five predictive characteristics was constructed and a corresponding nomogram was generated. The predictive model demonstrates robust calibration, discrimination, and clinical utility upon validation. By setting a threshold, the model can classify breast masses into low and high malignancy risk groups. Breast masses classified as low-risk can safely omitted from biopsy, thereby increasing the PPV for the remaining cases. As a result, this model improves the clinical utility of supplemental ultrasound in women with dense breasts.
Prognostic impact of erector spinae muscle cross-sectional area in patients with pleuroparenchymal fibroelastosis
Authors: Kitahara Shinsuke , Abe Mitsuhiro , Kono Chiyoko , Sakuma Noriko , Ishi Daisuke , Kawasaki Takeshi , Ikari Jun , Suzuki Takuji 
Published: August 2023

Abstract
Pleuroparenchymal fibroelastosis (PPFE) progresses slowly but sometimes relatively quickly, leading to decreased activities of daily living (ADL) and muscle weakness. Skeletal muscle atrophy and muscle weakness in patients with chronic obstructive pulmonary disease (COPD) may be caused by cachexia and are associated with reduced ADLs and increased risk of death. However, the association between skeletal muscle mass and the prognosis of patients with PPFE remains unknown. We retrospectively analysed the clinical significance of the erector spinae muscle cross-sectional area (ESMCSA), a skeletal muscle index, and predictors of mortality within 3 years in 51 patients with PPFE and 62 patients with COPD. Patients with PPFE had significantly lower ESMCSA than those with COPD, and lower ESMCSA (< 22.57 cm2) was associated with prognosis within 3 years (log-rank test; p = 0.006), whereas lower body mass index (BMI) showed no association. Multivariate analysis showed that ESMCSA was an independent predictor of mortality within 3 years in patients with PPFE (hazard ratio, 0.900; 95% confidence interval: 0.834–0.964, p = 0.003). These results suggest the importance of monitoring ESMCSA in patients with PPFE and that assessing skeletal muscle mass in patients with PPFE could be a more useful prognostic indicator than BMI.