bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of ceramic particles additives on the mechanical properties and machinability of carbon fiber/ polymer composites
Authors: Ali Noor Hassan , Shihab Suha K. , Mohamed Muzher T. 
Published: March 2023

Abstract
Hybrid polymer composites have recently become the interest of the world and their uses are increasing in various applications, especially mechanical, electronic, and other applications. Recently, advanced machining techniques for hybrid polymer composites have been used to solve many problems during machining processes, including the ability to form complex shapes, high performance, better surface features, and high levels of accuracy. Among many machining processes, Abrasive Water Jet Machining (AWJM) has attracted the attention of many researchers and engineers in many industries. In this study, hybrid polymer composites consisting of an epoxy matrix reinforced with six layers of carbon fibers with a fixed percentage (15%) and ceramic particles (SiC and Al2O3) with different weight percentage were prepared by hand lay-up method. Mechanical tests including (tensile test, flexural test, impact and hardness test) were conducted. The results of mechanical tests showed that an improvement in the tensile and flexural properties was of (19.7%) in the tensile strength, (40%) in the modulus of elasticity, )55.26%( in the flexural strength and )69.49%( in the flexural modulus,) 12%( in the hardness using hybrid polymer constituent (70 wt% Epoxy+15 wt% CF +10 wt% Sic +5 wt% Al2O3). However, this hybrid polymer constituent includes lowest value of impact strength. Also, the morphological analysis indicated the uniform distribution of particles, the best defect-free surface and the bonding strength between the reinforcement and the epoxy matrix can be obtained using this constituent which has contributed to the improvement in the mechanical properties. The AWJM automation process was also performed based on design of experiment (Taguchi L18 design) to study the effect of the selected AWJM parameters (the hybrid polymer constituents, transverse velocity, stand of distance) on the different response variables (surface roughness, hardness, and kerf width). The analysis of variance (ANOVA) concluded that the hybrid polymer with the constituents (70 wt% Epoxy+15 wt% CF +10 wt% Sic +5 wt% Al2O3) has the most influential factor on the responses followed by transverse velocity, and then stand of distance. Moreover, the grey relational analysis was beneficially used to determine the multi optimization of AWJM parameters.
Development of a novel epigenetic clock resistant to changes in immune cell composition
Authors: Verdin Eric , Tomusiak Alan , Floro Ariel , Tiwari Ritesh , Riley Rebeccah , Matsui Hiroyuki , Andrews Nicolas , Kasler Herbert 
Published: March 2023

Abstract

Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG methylation values to predict chronological or biological age. Increases in predicted epigenetic age relative to chronological age (epigenetic age acceleration) are connected to aging-associated pathologies, and changes in epigenetic age are linked to canonical aging hallmarks. However, epigenetic clocks rely on training data from bulk tissues whose cellular composition changes with age. We found that human naive CD8+ T cells, which decrease during aging, exhibit an epigenetic age 15–20 years younger than effector memory CD8+ T cells from the same individual. Importantly, homogenous naive T cells isolated from individuals of different ages show a progressive increase in epigenetic age, indicating that current epigenetic clocks measure two independent variables, aging and immune cell composition. To isolate the age-associated cell intrinsic changes, we created a new clock, the IntrinClock, that did not change among 10 immune cell types tested. IntrinClock showed a robust predicted epigenetic age increase in a model of replicative senescence in vitro and age reversal during OSKM-mediated reprogramming.
Camp Lejeune Marine Cancer Risk Assessment for Exposure to Contaminated Drinking Water from 1955-1987
Authors: Rosenfeld Paul E. , Spaeth Kenneth R , McCarthy Savannah J , Winter Sophia C , Wilson Maddie S , Hagemann Matthew 
Published: March 2023

Abstract
This study utilizes guidance from the United States Environmental Protection Agency (USEPA) and Agency for Toxic Substances and Disease Registry (ATSDR) to calculate the cancer risk to United States Marines who were exposed to carcinogens in drinking water at Marine Corps Base Camp Lejeune. Camp Lejeune is a 233-square-mile Marine Corps training facility in North Carolina. Nearby dry cleaners, landfills, and underground storage tanks contaminated drinking water systems that served Camp Lejeune (ATSDR, 2017). Some of the most toxic contaminants found in the drinking water modeled by ATSDR include benzene, tetrachloroethylene (PCE), trichloroethylene (TCE), trans-1,2-dichloroethylene (DCE), and vinyl chloride (VC). ATSDR utilized MODFLOW and EPANET modeling software to determine the level of contamination in the three main drinking water systems at Camp Lejeune: Tarawa Terrace, Holcomb Boulevard, and Hadnot Point. This paper explains methodology for how to quantify cancer risk for the Marines who lived and served at Camp Lejeune from 1953 to 1987 using ATSDR’s health assessment, chemical contaminant modeling, and USEPA methodology. While VC and TCE were found to be the main risk drivers, benzene and PCE also contributed to the cumulative cancer risk. This analysis shows (1) that the cancer risk was greatest during the 1970s and 1980s, and (2) that the ingestion exposure pathway had the greatest contribution to overall cancer risk, followed by dermal adsorption, with the smallest contribution from inhalation.
Micro drill resistance instrument measurements at different feed speeds: Novel conversion algorithm for enhanced accuracy
Authors: YAO Jianfeng , LU Jun , fu liyong 
Published: March 2023

Abstract
Drill feed speed significantly affects the measurement accuracy and efficiency of the micro drill resistance instrument. Generally, different speeds are set according to the density of the wood to be drilled. It is necessary to convert the resistance data measured at different drill feed speeds into resistance data at a uniform speed to properly analyze resistance data. In this study, drill resistance data for a Paulownia wood block was measured with a self-made micro drill resistance instrument at different drill feed speeds. We found that the drill resistance is positively correlated with changes in its feed speed and the natural logarithm of change times for feed speed. We developed a conversion algorithm for the micro drill resistance instrument measurements at different feed speeds. The accuracy of the conversion algorithm is up to 95%. The algorithm can be used to convert the drill resistance of Paulownia wood measured at different drill feed speeds; it has reference value for the mutual conversion of other tree species’ drill resistance data measured at different feed speeds. This work may provide a feasible solution to improving micro drill resistance instrument accuracy when drill feed speed error is high.
Diagnosis and comprehensive treatment of pancreatic glucagonoma presenting with multiple metastases and recurring postoperatively
Authors: Yu Shenghui , Ge Muxi , Zhang Cheng , Chen Lang , Zhao Lei 
Published: March 2023

Abstract
Background: Pancreatic glucagonoma is a rare neuroendocrine neoplasm with malignant potential. At present, clinicians have a poor understanding of the disease, and the current epidemiology, diagnosis and comprehensive treatment of the disease have not been fully established.
Case presentation: Herein, we report two patients with such tumors, one a 60-year-old woman hospitalized for blood glucose elevation and recurrent necrolytic migratory erythema (NME) of the trunk and limbs. Imaging studies showed an area (~3 cm) of reduced enhancement at head of pancreas. Examination of the subsequent pancreaticoduodenectomy specimen confirmed a pancreatic neuroendocrine tumor (G2). The patient’s blood glucose normalized postoperatively, and her skin erythema cleared. During follow-up, however, intramuscular injections (30 mg) of long-acting release (LAR) octreotide acetate microspheres were required at 28-day intervals for recurrent NME, and there was apparent hepatic and retroperitioneal nodal involvement after 36 months. The second patient was a 32-year-old woman hospitalized for recurrent glossitis, perioral dermatitis, and NME of both lower limbs. Imaging studies revealed a low-density nodule (~2 cm) in tail of pancreas, as well as multiple space-occupying lesions of liver. Distal pancreatectomy was undertaken, with splenectomy and palliative resection of hepatic nodules, confirming metastasis of a primary pancreatic neuroendocrine tumor (G2) to liver. The NME resolved postoperatively, but this patient also received intramuscular octreotide LAR injections (30 mg) at 28-day intervals. After 6 months, percutaneous radiofrequency ablation of residual liver lesions took place.
Conclusions： In patients with multiple liver metastases, palliative surgical treatment may confer patient benefits and prolong survival. Those with hormonal-based symptoms are often well controlled through somatostatin analog (SSA) administration. postoperative adjuvant therapy of metastatic pancreatic glucagonoma has also obvious effects on the prognosis.
Review of the relationship performance between travel behavior and resident physical-mental health in China
Authors: Sun Hao 
Published: March 2023

Abstract
The influence of travel behavior on the physical and mental health of Chinese residents should be investigated, which is of great significance to succeed the healthy China. Through the information visualization software CiteSpace, the research trend of the literatures in the China Knowledge Network database (CNKI) and Web of Science database is analyzed. The common measurement methods and data analysis methods in the current research are introduced, and the research on the relationship between traffic behavior and residents' physical and mental health from the aspects of significant impact factors, spatial scale and type and impact mechanism is combed and evaluated.
On the conformal Ein invariants
Authors: Labbi Mohammed Larbi 
Published: March 2023

Abstract
For a compact Riemannian $n$-manifold $(M,g)$ of positive scalar curvature, the capital $\Ein$ invariant of $g$ is defined to be the infinimum over $M$ of the quotient of the scalar curvature by the maximal eigenvalue of the Ricci curvature. This is a re-scale invariant and belongs to the interval $(0,n]$. For a positive conformal class $[g]$, we define the conformal invariant $\Ein([g]):=\sup\{\Ein(g): g\in [g]\}$. In this paper, we prove vanihing theorems for Betti numbers and for the higher homotopy groups of $M$ under optimal lower bounds on $\Ein([g])$ assuming that $g$ is locally conformally flat. We establish an inequality relating our invariant to Schoen-Yau conformal invariant $d(M,[g])$ from which we deduce a classification result for locally conformally flat manifolds with higher $\Ein([g])$. We show that the class of locally conformally flat manifolds with $\Ein([g])>k$ is stable under the operation of connected sums for $0
The Extremal Sigma Index of Connected Graphs with Given Number of Pendant Vertices
Authors: Yang Jing , Deng Hanyuan 
Published: March 2023

Abstract
The Sigma index of a graph G = (V,E) is defined as the sum of (d(u)−d(υ))2 over all edges uυ ∈ E, where d(υ) denotes the degree of the vertex u in G. In this paper, we completely determine the extremal values of the Sigma index of connected graphs with n vertices and p pendant vertices (1 ≤ p ≤ n − 1), and characterize the corresponding extremal graphs.
Molecular Dynamic, Hirshfeld Surface, Computational Quantum and Spectroscopic analysis of 4-Hydroxy-1-Naphthaldehyde
Authors: Mir M. Amin , Jassal MMS , Andrews Kim 
Published: March 2023

Abstract
The compound 4-Hydroxy-1-Naphthaldehyde, was analysed experimentally and by computational methods using DFT method and B3LYP/6-311 + + G (d, p) basis set with respect to its FTIR, NMR, and UV-Visible spectrum. The NMR chemical shifts of carbon and protons in CDCl3 was determined by GIAO method. The oxygen containing site is more electronegative position in 4H1NA molecule, as per MEP study. The UV-Visible spectra in MeOH was done in gas phase theoretically and by TD-DFT technique. For the molecule of reference, HOMO-LUMO and Donor-Acceptor interactions were also taken into consideration. Investigations also looked into ELF, Fukui activity, and nonlinear optical properties. Additionally computed were temperature-dependent thermodynamic properties. Hirshfeld surface analysis characterize the 3D molecular interactions on crystal surface.
Wavelet Gated Multiformer for Groundwater Time Series Forecasting
Authors: Rodrigues Vitor Hugo Serravalle Reis , Junior Paulo Roberto de Melo Barros , Marinho Euler Bentes dos Santos , Silva Jose Luis Lima de Jesus 
Published: March 2023

Abstract
Developing accurate models for groundwater control is paramount for planning and managing life-sustaining resources (water) from aquifer reservoirs. Significant progress has been made toward designing and employing deep-forecasting models to tackle the challenge of multivariate time-series forecasting. However, most models were initially taught only to optimize natural language processing and computer vision tasks. We propose the Wavelet Gated Multiformer, which combines the strength of a vanilla Transformer with the Wavelet Crossformer that employs inner wavelet cross-correlation blocks. The self-attention mechanism (Transformer) computes the relationship between inner time-series points, while the cross-correlation finds trending periodicity patterns. The multi-headed encoder is channeled through a mixing gate (linear combination) of sub-encoders (Transformer and Wavelet Crossformer) that output trending signatures to the decoder. This process can improve the model's predictive capabilities. We have also used the Multifractal Detrended Cross-Correlation Heatmaps (MF-DCCHM) to extract cyclical trends from pairs of stations across multifractal regimes by denoising the pair of signals with Daubechies wavelets. Our dataset was obtained from a network of eight wells for groundwater monitoring in Brazilian aquifers, six rainfall stations, eleven river flow stations, and three weather stations with atmospheric pressure, temperature, and humidity sensors.
Comparative microbiome analysis reveals the variation in microbial communities between ‘Kyoho’ grape and its bud mutant variety
Authors: Wei Tong-Lu , Wang Ze-Hang , Shang Ya-Xin , Pei Mao-Song , Liu Hai-Nan , Yu Yi-He , Shi Qiao-Fang , Guo Da-Long 
Published: March 2023

Abstract
Background: Microbes are an important part of the vineyard ecosystem, which significantly influence the growth and development of grapevines. High-throughput microbiome sequencing can fully identify the microbial communities so as to help to guide viticulture and disease control. Previously, we identified a bud mutant variety, named ‘Fengzao’, from ‘Kyoho’ grapes. With both ‘Fengzao’ and ‘Kyoho’, we conducted high-throughput microbiome sequencing and investigated their microbial communities in different tissues.
Methods: Samples of fruit, stem and leaf were separately collected from ‘Fengzao’ and ‘Kyoho’. After microbiome sequencing, analysis of OTU (Operational Taxonomic Unit) and taxonomy were conducted. The species diversity among different samples were analyzed by performing alpha and beta diversity analysis.
Results: A total of 34 OTUs were identified from the different tissues of ‘Fengzao’ and ‘Kyoho’. There were obvious differences in the microbial communities between ‘Fengzao’ and ‘Kyoho’. The fruit and the stem are the tissues with relatively higher abundance of microbes, while the leaves contained less microbes. The fruit and stem of ‘Kyoho’ and the stem of ‘Fengzao’ had relatively higher species diversity based on the alpha diversity analysis. Proteobacteria, Enterobacteriaceae and Rhodobacteraceae had significantly high abundance in ‘Fengzao’. Firmicutes and Pseudomonas were highly abundant in the stems of ‘Kyoho’, and family of Spirochaetaceae, Anaplasmataceae, Chlorobiaceae, and Sphingomonadaceae, and genera of Spirochaeta, Sphingomonas, Chlorobaculum and Wolbachia were abundant in the fruits of ‘Kyoho’.
Conclusion: The fruit and the stem (but not leaf) of grapevines are important hosts for microbes, and there are significant differences in microbial compositions between ‘Fengzao’ and ‘Kyoho’. These identified microbes will be significant resources for the future researches on the quality regulation and disease control of grapevines.
CircSLC1A4 Mediates N-glycosylation of MUC13 to Promote Cell migration, invasion and EMT in Hepatocellular Carcinoma Through Up-regulation of B4GALT5 Expression
Authors: Zhang Xianfeng , Chen Zhiyuan , Che Jinhui , Zhang Yongjun , Liu Yubin , Tan Weimin 
Published: March 2023

Abstract
Background: HCC (hepatocellular carcinoma) is the most common type of hepatic cancers with an overall poor prognosis and an alarming rising incidence. There is an urgent need to explore novel therapeutic targets for HCC treatment.
Methods: QRT-PCR (quantitative real-time PCR) was applied to analyze the expression level of circSLC1A4 in HCC cell lines. Database analysis, ChIP (chromatin immunoprecipitation), DNA pulldown, RIP (RNA-binding protein immunoprecipitation) and RNA pulldown assays were implemented to investigate the molecular mechanism of circSLC1A4 in HCC. Co-IP (Co-immunoprecipitation) and GST (glutathione S-transferase) pulldown assays were performed to detect the protein-protein interactions.
Results: B4GALT5 (beta-1,4-galactosyltransferase 5) promotes cell migration, invasion and EMT (epithelial-mesenchymal transition) in HCC. In addition, the characteristics of circSLC1A4 in HCC were explored. Functionally, circSLC1A4 acts as a tumor-propeller in HCC via regulating B4GALT5. Specifically, circSLC1A4 recruits FOXH1 (forkhead box H1) to stimulate the transcription of B4GALT5 and recruits DDX3X (DEAD-box helicase 3 X-linked) to stabilize B4GALT5 mRNA (messenger RNA). Besides, circSLC1A4 mediates B4GALT5-induced N-glycosylation of MUC13 (mucin 13) and activates Wnt/β-catenin signaling via MUC13.
Conclusion: Our study manifested that circSLC1A4 mediates N-glycosylation of MUC13 to promote HCC cell migration, invasion and EMT via up-regulating B4GALT5, offering insight into HCC treatment.
COVID-19 Infection and Dementia: A Prospective Analysis of Time-Varying Risk, Subtypes, and Subpopulations from the UK Biobank
Authors: Cao Yaying , Feng Chengwu , Chen Jing , Liu Yunman , Sheng Aili , Li Shuai , Hu Yonghua , Yuan Changzheng , Xie Junqing , Zong Geng 
Published: March 2023

Abstract
Background: Although COVID-19 patients were suggested to experience worse cognitive outcomes, there is a paucity of evidence on time-varying risk of dementia, especially the subtypes, as well as among critical subpopulations.
Methods: Out of over 50000 individuals from general population in the UK Biobank, SARS-COV-2 infected patients between March 1, 2020, and July 31, 2021 and maximally 5:1 propensity score matched contemporary non-infected individuals were selected, with baseline dementia excluded. Matching was done on demographic characteristics, lifestyle, and comorbidities. Dementia was captured according to primary care, inpatient records, and death registry, with the follow-up ending at the earliest of outcome occurrence, death, or August 31, 2021. Associations were evaluated using time-varying hazard ratios (HRs) and odds ratios (ORs).
Results: With a mean age of 64.5 years for 18032 COVID-19 patients and 83,008 controls, participants were followed for a median of 247 (IQR: 204–305) days and 255 dementia cases occurred, including 90 Alzheimer’s disease (AD) cases and 42 vascular dementia (VaD) cases. Compared with matched controls, dementia risk declined drastically after COVID-19 infection and sustained for all-cause dementia, VaD, and other dementia. During the acute phase (first 30 days), COVID-19 infection was associated with increased risks of dementia, with HRs (95% CIs) being 12.77 (6.77, 24.08) for all-cause dementia, 9.21 (2.77, 30.59) for AD, 5.53 (1.69, 18.11) for VaD, and 25.35 (8.74, 73.56) for other dementia. Among those not hospitalized within 30 days of enrollment, elevated dementia risk remained for all-cause dementia, VaD, and other dementia, with ORs being 1.82, 4.55, and 1.64, respectively. Among most of the subpopulations classified by demographic characteristics, APOE genotype, and comorbidities (except for those with chronic obstructive pulmonary diseases at enrollment), COVID-19 infection was associated with an elevated all-cause dementia risk and no modification effect was detected.
Conclusion: Declined yet sustained elevated dementia risk since COVID-19 infection was found and vascular risk factors may need extra attention during the long-term follow-up. Increased dementia risk from COVID-19 infection also applied for the non-hospitalized during the acute phase and most subpopulations. The potential dementia risk associated with Omicron and newer variants warrants further evaluation.
Meclofenoxate Inhibits Aggregation of Alpha-synuclein in vitro
Authors: Parui Adhuna , Biswas Soumojit , Roy Ipsita 
Published: March 2023

Background:
α-Synuclein, a natively disordered protein, is a key component of Lewy
bodies, the ubiquitinated protein aggregates which are the pathological hallmark of Parkinson’s disease
(PD). Meclofenoxate (centrophenoxine) is a nootropic drug which has shown beneficial therapeutic
effects in various neuronal diseases. Administration of meclofenoxate enhanced levels of dopamine
and improved motor function in animal models of Parkinson’s disease (PD). Evidence suggested that
dopamine interacts with and modulates α-synuclein aggregation.

Objective:
The aim of this work was to investigate whether the observed positive effect of addition of
meclofenoxate, a nootropic agent, on dopamine level, could be correlated with its effect on aggregation
of α-synuclein.

Methods:
Purification of recombinant human α-synuclein was performed by anion exchange
chromatography. The purified protein was incubated in the absence and presence of meclofenoxate and
was analyzed for aggregation by Thioflavin T fluorescence spectroscopy. Conformational changes in
α-synuclein were monitored by fluorescence spectroscopy and fluorescence quenching studies using a
neutral quencher. Secondary structure analysis of α-synuclein was monitored by circular dichroism
spectroscopy.

Results:
Recombinant human α-synuclein was expressed and purified by anion-exchange
chromatography. Incubation of α-synuclein with meclofenoxate led to lowering aggregation in a
concentration-dependent manner. Reduction in formation of oligomers was seen which suggested the
formation of an off-pathway species which did not give rise to an aggregation-competent entity.
Fluorescence quenching studies revealed that the additive distorted the native conformation of α-
synuclein, leading to the formation of lower amounts of aggregation-prone species.

Conclusion:
In the presence of higher concentrations of meclofenoxate, α-synuclein undergoes a
change in its conformation. This change is not dependent on the concentration of the additive. This
non-native conformer promotes the formation of a species which does not undergo further aggregation.
Our study provides a mechanistic explanation of the earlier observation that meclofenoxate has a
beneficial effect on progression of PD in animal models.