bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extracellular traps are evident in Romanowsky‐stained smears of bronchoalveolar lavage from children with non‐cystic fibrosis bronchiectasis
Authors: Bleakley Amy S. , Kho Steven , Binks Michael J. , Pizzutto Susan , Chang Anne B. , Beissbarth Jemima , Minigo Gabriela , Marsh Robyn L. 
Published: August 2023

AbstractBackground and ObjectiveThe importance of extracellular traps (ETs) in chronic respiratory conditions is increasingly recognized but their role in paediatric bronchiectasis is poorly understood. The specialized techniques currently required to study ETs preclude routine clinical use. A simple and cost‐effective ETs detection method is needed to support diagnostic applications. We aimed to determine whether ETs could be detected using light microscopy‐based assessment of Romanowsky‐stained bronchoalveolar lavage (BAL) slides from children with bronchiectasis, and whether the ETs cellular origin could be determined.MethodsArchived Romanowsky‐stained BAL slides from a cross‐sectional study of children with bronchiectasis were examined for ETs using light microscopy. The cellular origin of individual ETs was determined based on morphology and physical contact with surrounding cell(s).ResultsETs were observed in 78.7% (70/89) of BAL slides with neutrophil (NETs), macrophage (METs), eosinophil (EETs) and lymphocyte (LETs) ETs observed in 32.6%, 51.7%, 4.5% and 9%, respectively. ETs of indeterminate cellular origin were present in 59.6% of slides. Identifiable and indeterminate ETs were co‐detected in 43.8% of slides.ConclusionBAL from children with bronchiectasis commonly contains multiple ET types that are detectable using Romanowsky‐stained slides. While specialist techniques remain necessary to determining the cellular origin of all ETs, screening of Romanowsky‐stained slides presents a cost‐effective method that is well‐suited to diagnostic settings. Our findings support further research to determine whether ETs can be used to define respiratory endotypes and to understand whether ETs‐specific therapies may be required to resolve airway inflammation among children with bronchiectasis.
Mineral extraction and long‐term human capital accumulation
Authors: Feng Chen , Zhang Yao , Zhao Renjie , Zhao Xiaolu 
Published: August 2023

AbstractThis study examines the long‐term impacts of early coal mining on human capital outcomes. Based on coal mines across 260 prefectures in late Qing China (c.1840–1912), we find that early coal mining led to a significant rise in schooling years in 2000. We trace the historical channels and show that the influence of early coal mining has persisted through and helped shape the modernization of China, which includes local industrialization and a complimentary supply of educational infrastructure. These results suggest that in contrast to other grabbing mineral extraction, inclusive coal mining systems benefit long‐term human capital accumulation and economic growth, not mining activity per se.
Sociality and the minimal self: On Dan Zahavi’s “group‐identification, collectivism, and perspectival autonomy”
Authors: Bower Matt E. M. 
Published: August 2023

AbstractI present and critically examine Dan Zahavi's view that minimal selfhood and self‐awareness per se do not have a social character. I argue that Zahavi's conception of the minimal self as fundamentally asocial makes it hard to comprehend the unity of the self and that it is partly the result of an overly narrow conception of what it might mean for the self to be social.
Cardiovascular and metabolic effects of hyperbilirubinemia in a cohort of Italian Olympic athletes
Authors: Di Gioia Giuseppe , Crispino Simone Pasquale , Monosilio Sara , Maestrini Viviana , Nenna Antonio , Segreti Andrea , Squeo Maria Rosaria , Lemme Erika , Ussia Gian Paolo , Grigioni Francesco , Pelliccia Antonio 
Published: August 2023

AbstractIntroductionBilirubin was supposed to have cardio‐metabolic protective role by signaling functions. Indeed, mild hyperbilirubinemia has immunosuppressive and endocrine activities and may offer protection against oxidative stress‐mediated diseases. Gilbert syndrome (GS) has been hypothesized to provide cardio‐metabolic benefits.ObjectiveTo investigate the prevalence of hyperbilirubinemia and its cardio‐metabolic effects in a cohort of elite Italian athletes engaged in different sports disciplines.MethodsWe enrolled 1492 elite athletes (age 25.8 ± 5.1) practising different disciplines (power, skills, endurance, and mixed) underwent blood, echocardiographic, and exercise tests. GS was diagnosed per exclusionem in athletes with isolated asymptomatic unconjugated hyperbilirubinemia.ResultsGS was highlighted in 91 athletes (6%; globally 9% male and 2.4% female); 82% were males (p < 0.0001) showing higher indirect bilirubin (0.53 ± 0.4 vs. 0.36 ± 0.24 mg/dL in females, p < 0.0001). GS athletes had fewer platelets (201 ± 35 vs. 214 ± 41, p = 0.01), higher iron (male: 124 ± 44 vs. 100.9 ± 34 mcg/dL, p < 0.0001; female: 143.3 ± 35 vs. 99.9 ± 42 mcg/dL, p < 0.0001), and lower erythrocyte sedimentation rate, (1.93 ± 0.9 vs. 2.80 ± 2.7 mm/H, p = 0.03). At multivariate analysis, male (OR 3.89, p = 0.001) and iron (OR 3.47, p = 0.001) were independently associated with GS. No significant differences were found in cardiac remodeling, heart rate, blood pressure, arrhythmias, or power capacity at stress test. Endurance athletes (313) presented higher total (p = 0.003) and indirect bilirubin (p = 0.001).ConclusionBilirubin has several metabolic effects (including immunosuppressive and endocrine) and plays a role in regulating antioxidant pathways exercise‐related with hematological consequences but seems not to affect significantly cardiovascular remodeling. Endurance athletes present higher bilirubin concentrations, likely as an adaptive mechanism to counteract increased oxidative stress.
The Yates, Conover, and Mantel statistics in 2 × 2 tables revisited (and extended)
Authors: Martín Andrés Antonio , Hernández María Álvarez , Gayá Moreno Francisco 
Published: August 2023

AbstractAsymptotic inferences about the difference, ratio or odds‐ratio of two independent proportions are very common in diverse fields. This article defines for each parameter eight conditional inference methods. These methods depend on: (1) using a chi‐squared type statistic or a z type one; (2) using the classic Yates continuity correction or the less well‐known Conover one; and (3) whether the p‐value of the test is determined by doubling the one‐tailed p‐value or by the Mantel method (asymmetrical approach). In all cases, the conclusions are: (i) the methods based on the chi‐squared statistic should not be used, as they are too liberal; (ii) for those in favor of using the criterion of doubling the p‐value, the best method is using the z statistic with Conover continuity correction; and (iii) for those in favor of the asymmetrical approach, the best method is based on the z statistic with Conover continuity correction and the Mantel p‐value.
Spatial transcriptomics drives a new era in plant research
Authors: Yin Ruilian , Xia Keke , Xu Xun 
Published: August 2023

SUMMARYThe plant community lags far behind the animal and human fields concerning the application of single‐cell methodologies. This is primarily due to the challenges associated with plant tissue dissection and the limitations of the available technologies. However, recent advances in spatial transcriptomics enable the study of single‐cells derived from plant tissues from a spatial perspective. This technology is already successfully used to identify cell types, reconstruct cell‐fate lineages, and reveal cell‐to‐cell interactions. Future technological advancements will overcome the challenges in sample processing, data analysis, and the integration of multiple‐omics technologies. Thanks to spatial transcriptomics, we anticipate several plant research projects to significantly advance our understanding of critical aspects of plant biology.
Paraneoplastic sacroiliitis
Authors: Arad Uri , Werren Charles , White Douglas 
Published: August 2023

A man in his early 70s presented with stiffness and aching in the shoulder and pelvic girdles. His C reactive protein level was elevated at 116 mg/L, leading to an initial diagnosis of polymyalgia rheumatica. Treatment with prednisone at 20 mg/day provided limited improvement and relapses recurred despite concomitant immunosuppressive agents. Extensive investigations failed to reveal an underlying aetiology.Five years later, gross painless haematuria led to the detection of an invasive papillary urothelial carcinoma. A review of the staging CT scan revealed findings compatible with bilateral erosive sacroiliitis, which had developed since his initial presentation. Radical cystoprostatectomy provided temporary relief but after a further 9 months, symptoms relapsed, and metastatic spread was discovered.Paraneoplastic sacroiliitis is a rare clinical entity; and to the best of our knowledge, this is the first reported case associated with a solid tumour.
Developing a supportive and palliative care intervention for patients with allogeneic stem cell transplantation: protocol of a multicentre mixed-methods study (allo-PaS)
Authors: Pralong Anne , Herling Marco , Holtick Udo , Scheid Christoph , Hellmich Martin , Hallek Michael , Pauli Berenike , Reimer Alinda , Schepers Carolin , Simon Steffen T 
Published: August 2023

IntroductionAlthough allogeneic stem cell transplantation (allo-SCT) is a curative treatment for many haematological malignancies, it is often associated with a high morbidity and mortality. Yet, little is known about the needs for supportive and palliative care among allo-SCT recipients. Moreover, targeted interventions that reduce symptom burden and suffering are still lacking. The present study aims to inform a supportive-palliative care intervention for patients with allo-SCT and their informal carers by exploring their experience and assessing their needs, especially their existential concerns, regarding four research topics: symptom burden and quality of life; coexistence of a chance for cure and a relevant risk of dying; change in goals of care; dying phase.Methods and analysisThis is a descriptive mixed-methods study in progress with a convergent parallel design. Data on the four research topics will be collected and analysed separately in three steps: (1) qualitative semi-structured interviews among 20 patients, 20 informal carers and 12 healthcare providers (HCPs) and focus groups among 12–24 HCPs; (2) a quantitative cross-sectional survey with validated questionnaires and self-developed questions among 100 patients, 100 informal carers and 50 HCPs; (3) a retrospective case analysis of all deceased patients who underwent an allo-SCT between 2010 and 2019, with collection of quantitative and qualitative data. The qualitative and quantitative data sets will be finally merged for comparison and interpretation. Results will serve to develop a supportive-palliative care intervention.Ethics and disseminationThe Ethics Commission of the Faculty of Medicine of the University of Cologne approved this study (20–1370_2). The study results will be published in peer-review journals, be presented at congresses and will be translated into clinical practice through the development of the palliative-supportive care intervention.Trial registration numberDRKS00027290 (German Clinical Trials Register).
Impact of the COVID-19 pandemic on mortality trends in Japan: a reversal in 2021? A descriptive analysis of national mortality data, 1995–2021
Authors: Tanaka Hirokazu , Togawa Kayo , Katanoda Kota 
Published: August 2023

ObjectiveThe COVID-19 pandemic led to an increase in mortality in most countries in 2020, deviating from prior decreasing trends. In Japan, however, mortality was suggested to decrease in 2020. This study investigated long-term mortality trends and cause-specific contributions, focusing on the period of the COVID-19 pandemic in Japan.DesignWe analysed Japanese age-standardised mortality rates (ASMRs) from 1995 to 2021 using vital statistics.Main outcome measuresThe cause-specific annual ASMR changes were calculated in comparison with the previous year over the abovementioned period.ResultsThere was a general downward trend in overall ASMR for both sexes until 2020 followed by a small increase in 2021. In men, the all-cause ASMR (per 100 000 persons) decreased from 1352.3 to 1328.8 in 2020 (−1.74% from 2019), and increased to 1356.3 in 2021 in men (+2.07% from 2020). In women, the all-cause ASMR decreased from 746.0 to 722.1 in 2020 (−3.20% from 2019), and increased to 737.9 (+2.19% from 2020) in 2021. ASMRs from malignant neoplasms, pneumonia, accidents and suicide (men only) continued to decrease during the COVID-19 pandemic while the trend of cardiovascular mortality increased in 2021. Analysis of ASMR changes revealed that COVID-19, senility, cardiovascular disease and ‘other causes not classified as major causes’ contributed to the all-cause mortality increase in 2021.ConclusionsIn Japan, the decreasing trend in overall mortality continued in 2020 despite the COVID-19 pandemic. However, approximately 2% mortality increase was observed in 2021, which was attributable to COVID-19, senility, cardiovascular disease and ‘other causes’. The year 2021 was a turning point of mortality trends in Japan, although continued monitoring is warranted.
Perspectives of healthcare and social support sector policymakers on potential solutions to mitigate financial impact among people with TB in Mozambique: a qualitative study
Authors: Nhassengo Pedroso , Yoshino Clara , Zandamela Américo , De Carmo Verónica , Burström Bo , Khosa Celso , Wingfield Tom , Lönnroth Knut , Atkins Salla 
Published: August 2023

ObjectivePeople with tuberculosis (TB) and their households face severe socioeconomic consequences, which will only be mitigated by intersectoral collaboration, especially between the health and social sectors. Evidence suggests that key factors for successful collaboration include shared goals, trust, commitment, resource allocation, efficient processes and effective communication and motivation among collaborating parties. This study aimed to understand healthcare and social support sector policymakers’ perspectives on potential solutions to mitigate financial impact among people with TB and their households in Mozambique.DesignQualitative study with primary data collection through one-to-one in-depth interviews.SettingGaza and Inhambane provinces, Mozambique.ParticipantsPolicymakers in the health and social support sector.ResultsA total of 27 participants were purposefully sampled. Participants were asked about their perspectives on TB-related financial impact and potential solutions to mitigate such impact. Participants reported that people with TB are not explicitly included in existing social support policies because TB per se is not part of the eligibility criteria. People with TB and underweight or HIV were enrolled in social support schemes providing food or cash. Two themes were generated from the analysis: (1) Policymakers suggested several mitigation solutions, including food and monetary support, but perceived that their implementation would be limited by lack of resources; and (2) lack of shared views or processes related to intersectoral collaboration between health and social support sector hinders design and implementation of social support for people with TB.ConclusionDespite health and social sector policymakers reporting a willingness for intersectoral collaboration to mitigate TB-related financial impact, current approaches were perceived to be unilateral. Collaboration between health and social support sectors should focus on improving existing social support programmes.
Association between serum triglyceride to high-density lipoprotein cholesterol ratio and sarcopenia among elderly patients with diabetes: a secondary data analysis of the China Health and Retirement Longitudinal Study
Authors: Lin Yinghe , Zhong Shanshan , Sun Zhihua 
Published: August 2023

ObjectivePrevious studies investigating the association between the serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and the occurrence of sarcopenia in different populations have yielded inconsistent results. This study aimed to investigate the potential association between TG/HDL-C ratio and sarcopenia among elderly Chinese patients with diabetes.DesignA secondary data analysis.SettingThis was a secondary analysis of data from the China Health and Retirement Longitudinal Study.ParticipantsIn this study, 752 elderly individuals with diabetes were included after excluding individuals aged <60 years old, those with missing data for the assessment of sarcopenia and missing measurements for plasma glucose or glycated haemoglobin.Outcome measuresThe primary information included TG/HDL-C ratio, muscle strength, physical performance, muscle mass and covariables. The association between TG/HDL-C ratio and sarcopenia was assessed using ordinal logistic regression and linear regression analysis.ResultsOn multivariate ordinal logistic regression, among male patients, compared with those with the lowest quartile of TG/HDL-C ratio (≤1.41), those with the highest quartile (>4.71) had a significantly lower risk of more severe sarcopenia (OR 0.24, 95% CI 0.10 to 0.54). Similarly, among female patients, compared with those with the lowest quartile of TG/HDL-C ratio (≤2.07), those with the highest quartile (>5.61) had a significantly lower risk of more severe sarcopenia (OR 0.17, 95% CI 0.07 to 0.44). In multivariate linear regression, male patients with the highest quartile of TG/HDL-C ratio (β=0.36, 95% CI 0.20 to 0.51) had higher muscle mass than those with the lowest quartile. Similarly, female patients with the highest quartile of TG/HDL-C ratio (β=0.31, 95% CI 0.10 to 0.51) had higher muscle mass than those with the lowest quartile.ConclusionsThere was a negative association between TG/HDL-C ratio categorised by quartile and sarcopenia, which indicates that a higher TG/HDL-C ratio may be related to better muscle status.
Special Delivery: Programming with Mailbox Types
Authors: Fowler Simon , Attard Duncan Paul , Sowul Franciszek , Gay Simon J. , Trinder Phil 
Published: August 2023

The asynchronous and unidirectional communication model supported by mailboxes is a key reason for the
success of actor languages like Erlang and Elixir for implementing reliable and scalable distributed systems. While many actors may send messages to some actor, only the actor may (selectively) receive from its mailbox. Although actors eliminate many of the issues stemming from shared memory concurrency, they remain vulnerable to communication errors such as protocol violations and deadlocks.
Mailbox types are a novel behavioural type system for mailboxes first introduced for a process calculus by de’Liguoro and Padovani in 2018, which capture the contents of a mailbox as a commutative regular expression. Due to aliasing and nested evaluation contexts, moving from a process calculus to a programming language is challenging. This paper presents Pat, the first programming language design incorporating mailbox types, and describes an algorithmic type system. We make essential use of quasi-linear typing to tame some of the complexity introduced by aliasing. Our algorithmic type system is necessarily co-contextual, achieved through a novel use of backwards bidirectional typing, and we prove it sound and complete with respect to our declarative type system. We implement a prototype type checker, and use it to demonstrate the expressiveness of Pat on a factory automation case study and a series of examples from the Savina actor benchmark suite.
SkyBridge 2.0: A Fine-grained Vertical 3D-IC Technology for Future ICs
Authors: Bhat Sachin , Li Mingyu , Kulkarni Sourabh , Moritz Csaba Andras 
Published: August 2023

Gate-all-around field effect transistors (FETs) are set to replace FinFETs to enable continued miniaturization of ICs in the deep nanometer regime. IMEC and IRDS roadmaps project that 3D integration of gate-all-around FETs is a key path for the IC industry beyond 2024. In this article, we present SkyBridge 2.0, an IC technology featuring high density fine-grained 3D integration of vertical gate-all-around nanowire FETs, contacts, and interconnect while also solving 3D routability. We utilize industry-standard EDA tools to develop a customized design and technology co-optimization (DTCO) flow to design and evaluate SkyBridge 2.0. This DTCO flow covers process emulation of standard cells and SRAM to enable scalable manufacturing pathway, TCAD characterization of vertical nanowire FETs to obtain IV and CV characteristics, compact modeling accurately the device behavior, RC parasitic extraction of 3D interconnects and performance, and power and area assessment using ring oscillators. The technology assessment using ring oscillators shows that SkyBridge 2.0 at the chosen design point, using 10 nm nanowires, achieves ∼18% performance and 31% energy efficiency benefits compared to 7 nm FinFET technology. Area analysis of logic cells shows up to six times density benefits versus aggressively scaled 2D-CMOS cells. In addition to logic, we architect 3D SRAM to support low-power memory designs. SkyBridge 2.0 SRAM shows ∼20% improvement in read and write static noise margin, up to three times lower leakage current, and up to four times density benefits compared to 7 nm FinFET technology.
MANAGEMENT OF IRREGULAR ASTIGMATISM AFTER CORNEAL ULCER WITH RGP CONTACT LENS IN PATIENTS WITH HIGH MYOPIA
Authors: Noviantari I Gusti Agung Ratna , Handayani Ariesanti Tri 
Published: August 2023

Introduction: RGP contact lenses are indicated for correcting refractive errors in cases of high myopia and irregular astigmatism due to changes in the corneal curvature.
Case Report: A 30-year-old female came with complaints of redness, pain, glare, blurred vision, and yellow discharge and tearing on the left eye for 2 days, history of using Soft Contact Lens (SCL) since 10 years old due to myopia. Visual Acuity of the right eye (VOD) with glasses was 6/12 and VA of the left eye (VOS) was 1/300. The patient was diagnosed with left eye corneal ulcer and was given levofloxacin eye drops, hydroxypropyl methylcellulose eye drops, and vitamin C 1000 mg. The left eye's corneal ulcer healed after three days, but the scarring left the cornea's surface uneven.. Patients were advised to replace the contact lenses with RGP contact lenses. After the RGP fitting, the appropriate size was obtained in both eyes and the patient adapted well with VOD RGP 1.0 and VOS RGP 1.0 False. The patient felt helped by the RGP contact lens.
Discussion: RGP was given because it helped reduce the bacterial infection risk. RGP has a higher oxygen transmissibility and maintains the cornea's curvature to become more regular. It can be utilized as an optical device to repair excessive myopia in addition to irregular astigmatism.
Conclusion: RGP contact lens can be an option for irregular astigmatism after corneal ulcers due to the SCL use in patients with high myopia to provide good outcomes.