bluuebunny/crossref_metadata_2025_split huggingface dataset:
A nomogram for predicting prognostic risk factors in individuals with poor grade aneurysmal subarachnoid hemorrhage: a retrospective study
Authors: Song Li , Oppong Marvin Darkwah , Dammann Philipp , Wrede Karsten H. , Ahmadipour Yahya , Gümüs Meltem , Dinger Thiemo Florin , Rauschenbach Laurèl , Li Yan , Frank Benedikt , Sure Ulrich , Jabbarli Ramazan 
Published: January 2025

AbstractPoor-grade aneurysmal subarachnoid hemorrhage (PGASAH) is associated with high mortality and morbidity despite advanced treatments. Accurate prediction of prognosis remains a clinical challenge. This study aimed to identify independent risk factors and develop a predictive nomogram for unfavorable outcomes in PGASAH patients. This retrospective study included 348 PGASAH patients treated between 2003 and 2016. Univariate and multivariate logistic regression analyses were performed to evaluate the association of premorbid conditions, admission aSAH clinical parameters, admission laboratory parameters, and clinical complications with unfavorable outcomes, defined as mRS > 2 at 6 months. Independent predictors were identified, and a nomogram was constructed to assess predictive accuracy and clinical utility. The median age of PGASAH patients was 55.1 years, 64.9% were females. Independent predictors of unfavorable outcomes (mRS > 2) at 6 months included age > 55 years (aOR = 2.44), cardiac valve disease (aOR = 6.50), dilated pupils at admission (aOR = 2.64), early infarction (aOR = 5.56), and delayed cerebral ischemia (aOR = 5.09). The nomogram demonstrated good predictive performance with an AUC of 0.807. Decision curve analysis affirmed its clinical applicability. The intuitive nomogram helps physicians predict PGASAH prognosis at discharge, improving long-term management, optimizing resource allocation, and enhancing patient and family awareness and psychological preparedness. External validation is required for broader clinical use.
The i-FSC proxy for predicting inter-event and spatial variation of topographic site effects
Authors: Bou Nassif Aline , Maufroy Emeline , Lacroix Pascal , Chaljub Emmanuel , Causse Mathieu , Bard Pierre-Yves 
Published: January 2025

Abstract
Our study focuses on predicting topographic amplification of ground motion in the near-source region, where seismic rays reach the free-surface at varying incidence angles. We rely on data from previous 3D numerical simulations conducted on a topographic relief with a homogeneous medium. First, using neural networks, we identify which key parameters, describing the geometric characteristics of the relief relative to the seismic source position, control ground motion amplification. Then, we determine the functional form that relates these parameters to the simulated amplifications. Subsequently, we conduct a regression study to develop a model of topographic amplification, referred to as the i-FSC proxy (Illuminated Frequency-Scaled Curvature). Our estimator depends on the frequency-scaled (1) curvature, a parameter that accounts for the occurrence of amplifications over convex topographies and de-amplification over concave ones; (2) normalized illumination angle, a newly defined parameter that quantifies the slope exposure to the incoming wavefield, accounting for high amplification on slopes oriented opposite to the seismic source. The illumination parameter reduces the uncertainties of the proxy by a factor of 2 compared to estimators that rely solely on curvature. The proxy does not require high computational resources. It uses a digital elevation map and a seismic source position to predict amplification factors (without lithological effects) for an S-wave at any site on the surface topography. It allows exploration of variations in topographic amplification near seismic sources, representing a significant breakthrough as areas closest to the fault typically sustain the highest damages. A MATLAB script performing the i-FSC calculations is provided.
The Effects of Criminalisation on Activists: The Case of the NoTAP Environmental Movement
Authors: Di Ronco Anna 
Published: January 2025

AbstractDoes criminalisation have “chilling effects” on activists? If so, which are the criminalisation phases or strategies that discourage activists to act freely and in exercise of their human rights? This article investigates the chilling effects of criminalisation beyond the phases or strategies of police repression, labelling/stigmatisation, and surveillance, which have been addressed in the relevant multi-disciplinary literature thus far. Using the case study of the criminalised NoTAP environmental movement opposing a pipeline megaproject in the Italian southeastern Puglia region, this article shows the importance of investigating chilling effects on activists who have had experiences with the criminal justice system and with punitive measures outside the criminal law, such as administrative fines. It ends with an invitation for activist criminologists to contribute more substantially to this area of research, and to support activists throughout the “criminalisation cycle” - and through the most daunting phases of criminalisation, in particular.
Teacher-child talk in Shared-book Reading with Preschoolers: Linkages between Teacher Questioning and Child Responsiveness
Authors: Wu Yanpeng , Chen Si , Wang Xuerong , Qiao Peijing , Jiang Yinan 
Published: January 2025

Abstract
Teacher-child shared-book reading is an everyday activity that promotes preschoolers’ oral language and reading development. Previous studies have investigated various facets of teachers’ questioning techniques. Little research, however, has focused on text-based questions (TQ) and life-experience-based questions (LQ) and how they are associated with children’s responsiveness. Furthermore, teachers’ questioning in the Mandarin Chinese context remains underexplored. This study examines how text-based questions and life-experience based questions influenced teacher-child talk during two shared-book reading activities. The participants included 88 children and 15 teachers who were randomly paired with 5 to 7 children for one-on-one shared book reading sessions on different themes, totaling 88 dyads. All the sessions were videotaped and transcribed. We coded teachers’ questions by type and content based on level of cognitive demand, and the form of response elicited from the children. The results indicate that life-experience based questions significantly, positively predicted children’s verbal response, when controlling for the variables of children’s Expressive Vocabulary Test scores, age, quantity of teachers’ questions, and book themes. Conversely, text-based questions negatively predicted children’s verbal responses. Open questions (rather than closed questions) were associated with increased verbal response from the children. These findings suggest that teachers could increase the effectiveness of shared-book reading and preschoolers’ engagement in discussions by incorporating more open-ended, life-experience based questions.
Continual Learning in Medicine: A Systematic Literature Review
Authors: Bruno Pierangela , Quarta Alessandro , Calimeri Francesco 
Published: January 2025

AbstractContinual Learning (CL) is a novel AI paradigm in which tasks and data are made available over time; thus, the trained model is computed on the basis of a stream of data. CL-based approaches are able to learn new skills and knowledge without forgetting the previous ones, with no guaranteed access to previously encountered data, and mitigating the so-called “catastrophic forgetting” phenomenon. Interestingly, by making AI systems able to learn and improve over time without the need for large amounts of new data or computational resources, CL can help at reducing the impact of computationally-expensive and energy-intensive activities; hence, CL can play a key role in the path towards more green AIs, enabling more efficient and sustainable uses of resources. In this work, we describe different methods proposed in the literature to solve CL tasks; we survey different applications, highlighting strengths and weaknesses, with a particular focus on the biomedical context. Furthermore, we discuss how to make the methods more robust and suitable for a wider range of applications.
High Content Image Analysis of Cellular Responses of the Murine J774A.1 Cell Line and Primary Human Cells Alveolar Macrophages to an Extended Panel of Pharmaceutical Agents
Authors: Tietze Lysann , Urbano Laura , Eisenmann Stephan , Schwarzinger Jacqueline , Kollan Julia , Forbes Ben , Dailey Lea Ann , Hädrich Gabriela 
Published: January 2025

Abstract

Introduction

In vitro screening of macrophages for drug-induced effects, such as phospholipidosis, is useful for detecting potentially problematic compounds in the preclinical development of oral inhaled products. High-content image analysis (HCIA) is a multi-parameter approach for cytotoxicity screening. This study provides new insights into HCIA-derived response patterns of murine J774A.1 cells and primary human alveolar macrophages (hAM).

Methods
Several compounds were compared with reference groups (cationic amphiphilic drugs and apoptosis inducers) at different concentrations (0.01 to 10 µM). After incubation, cells were stained with fluorescence markers and HCIA was performed (Cytation™ 5 Cell Imaging System). Ten parameters were analysed: non-adherent cells, increased or reduced mitochondrial activity, membrane permeability, cell area, nuclear area, polynucleated cells, vacuole area, neutral and phospholipid content. A new system of response categorisation was developed for data analysis.

Results
Murine J774A.1 cells exhibited a drug-induced response pattern that was distinct to the corresponding pattern of hAM cells. Comparison with the literature revealed that primary cells (rat or human origin) have similar response patterns, while cell lines (mouse, rat or human) exhibited a different response pattern. Hierarchical clustering revealed toxicologically aligned clusters of compounds, suggesting potential use for understanding mechanisms of drug effects in cell lines and primary cells.

Conclusions
Valuable information for selecting a suitable cell type for HCIA screening of macrophage responses to drug compounds is provided. All cell types were suitable for screening drug-induced phospholipidosis. Still, human primary alveolar macrophages responded differently to drug treatment compared to macrophage cell lines and may be required to evaluate broader response-patterns and mechanisms of toxicity.
Epistemic oppression and the concept of coercion in psychiatry
Authors: Faissner Mirjam , Braun Esther , Hempeler Christin 
Published: January 2025

AbstractCoercion is still highly prevalent in contemporary psychiatry. Qualitative research indicates, however, that patients and psychiatric staff have different understandings of what they mean by ‘coercion’. Psychiatric staff primarily employ the concept as referring to instances of formal coercion regulated by law, such as involuntary hospital admission or treatment. Patients, on the other hand, use a broader concept, which also understands many instances of informal psychological pressure as coercive. We point out that the predominance of a narrow concept of coercion in psychiatry can have negative consequences for patients, and argue that this difference in how the concept ‘coercion’ is used is both grounded in epistemic oppression and reinforces such oppression. Epistemic oppression, as defined by Dotson, refers to the persistent epistemic exclusion of members of marginalized groups from participation in practices of knowledge production. We first demonstrate how patients may experience inferential inertia when communicating their experiences of coercion. We then show that the resulting predominance of a narrow concept of coercion in psychiatry can be described as a case of hermeneutical injustice in a context shaped by institutional hermeneutical ignorance. We argue for a change in institutional practices in psychiatry that allows for the adequate consideration of patients’ perspectives on coercion.
Analysing the impact of energy price increases on the vulnerable using the fuel poverty index: a case study of Kobe, Japan
Authors: Tabata Tomohiro , Tsai Peii 
Published: January 2025

Abstract
The global economic recovery from the COVID-19 pandemic and the Russian invasion of Ukraine have significantly increased global energy prices, resulting in higher household burdens for citizens. This study uses fuel poverty indicators to determine household vulnerability to increase in energy price in Japan. A web questionnaire was conducted asking about household income and fuel bills in 2021 and 2022, using Kobe City, Japan, as a case study. As the result, the percentage of fuel-poor households in 2022 was 5.39%, an increase of 0.23% over 2021. This suggests that fuel-poor households are increasing in response to increasing energy prices. The 2022 fuel poverty rate for elderly households was 1.48%, and it was 3.91% for households other than the elderly. Analysis result regarding the characteristics of households determined to be fuel-poor indicated that single-parent households were more likely to fall into fuel poverty than average households. A model combining binomial logistic regression and multiple regression analyses was derived to measure the effect of fuel poverty measures based on the questionnaire survey results. The study results of measures to reduce the time spent using climatization equipment during the daytime in summer by implementing energy sharing showed that all households and single-parent households could move out of fuel poverty. However, elderly households could not move out of fuel poverty, and an additional condition for breaking out of fuel poverty was an increase in the annual household income of elderly households by 0.2 million JPY (Japanese Yen).
Successful pediatric heart transplantation with bivalirudin use in a cyanotic single ventricle patient with an intracorporeal continuous flow ventricular assist device and heparin-induced thrombocytopenia
Authors: Sainathan Sandeep , Mulinari Leonardo 
Published: January 2025

AbstractWe describe a case of profound coagulopathy during orthotopic heart transplantation in a cyanotic single ventricle pediatric patient with an intracorporeal continuous flow ventricular assist device performed on bivalirudin for heparin-induced thrombocytopenia. This was successfully managed with central veno-arterial extracorporeal membrane oxygenation and hemofiltration as an adjunct to treat bivalirudin-induced coagulopathy due to lack of a reversal agent for bivalirudin.
Nonoperative Management of Gartland Type II Supracondylar Humeral Fractures: A Comprehensive Review
Authors: Booker Michaela , Sumandea Faith , Swarup Ishaan , Pandya Nirav 
Published: January 2025

Abstract

Purpose of Review
This review aims to provide a comprehensive analysis of the nonoperative management of Gartland Type II fractures in pediatric patients.

Recent Findings
Supracondylar humeral fractures (SCF) are one of the most common traumatic fractures in pediatric populations, characterized as transverse fractures at the distal humerus between the medial and lateral columns. Early studies strongly opposed closed reduction and casting as an acceptable treatment modality for Gartland type II fractures as an early case series showed high rates of complications; however, more recent studies have suggested better outcomes.

Summary
The optimal management of Gartland Type II supracondylar fractures has yet to be fully elucidated. This review highlights the indications, complications, and outcomes of nonoperative Gartland Type II supracondylar humeral fracture management. Additionally, it demonstrates the need for further research to inform guidelines on managing this condition.
Errors in the Spontaneous Language of Survivors of Pediatric Cerebellar Tumors
Authors: Svaldi Cheyenne , Galli Juan-Ignacio , Paquier Philippe , Keulen Stefanie , Van Elp Henrieke , Catsman-Berrevoets Coriene , Kingma Annet , Jonkers Roel , Kohnen Saskia , de Aguiar Vânia 
Published: January 2025

Abstract
Pediatric cerebellar tumor survivors may present with spontaneous language impairments following treatment, but the nature of these impairments is still largely unclear. A recent study by Svaldi et al. (Cerebellum. 23:523-44, 2023) found a broad spectrum of spontaneous language impairments irrespective of postoperative cerebellar mutism syndrome (pCMS) diagnosis in long-term pediatric cerebellar tumor survivors. Several patients presented with reduced grammatical or lexical accuracy, but a detailed error analysis was lacking. The present study builds on this study by 1) investigating the error types in spontaneous language across three language processing levels in the same participant group and 2) by evaluating the possible association between pCMS and the processing nature of the language impairments. Spontaneous language was evaluated in 12 long-term survivors of pediatric cerebellar tumors (M(SD) = 4;8(3;8) years), of whom five were diagnosed with pCMS. The proportion of occurrence of each error type was compared between each patient and five matched controls using individual case statistics, reflecting (lexico-)phonological (i.e., phonemic paraphasias), lexical-semantic (e.g., empty speech) and morphosyntactic processing (e.g., verb inflection errors). Each patient showed a significantly higher proportion of at least one of the included error types across all language processing levels. A higher proportion of general-all-purpose verbs and inaccurate verb inflection were the most common errors and respectively reflected lexical-semantic and morphosyntactic processing. Additional language impairments were identified using the error analysis that were not identified with standard language measures and psycholinguistic analysis, suggesting the added diagnostic value of error analyses.
Chemical fingerprinting of European radiolarites and raw material economies from the Moravian Aurignacian
Authors: Moník Martin , Nerudová Zdeňka , Gregar Filip , Pluháček Tomáš , Součková Jitka , Hamrozi Petr 
Published: January 2025

Abstract
Chemical fingerprinting and spectrophotometry were combined to conduct a provenance analysis of radiolarite artefacts from three Moravian (Czech Republic) Aurignacian sites of Tvarožná I, Nová Dědina I and Milovice I. Of the different methods used, laser ablation with inductively coupled plasma mass spectrometry (LA-ICP-MS) was the best suited to distinguish the different areas containing radiolarite outcrops. Based on their chemical fingerprint, Moravian Aurignacian radiolarite artefacts were most likely imported from the western Slovak part of the Pieniny Klippen Belt. The abundant radiolarite outcrops in the Vienna region were apparently ignored, with the possible exception of two radiolarite artefacts from the Milovice I site. However, these could also have been manufactured from gravel radiolarites found around the site. Upon assigning other lithologies from Aurignacian sites in Moravia to their areas of provenience, it transpired those imports derived primarily from non-south-western regions. A similar situation was previously observed in the Moravian Szeletian, possibly indicating information exchange between the two Upper Palaeolithic cultures. Although the subsequent Gravettian culture relied more on long-distance imports, north-eastern − south-western movements and transfers were predominant up until the end of the Moravian Upper Palaeolithic, largely due to the communication corridor of the Moravian Gate. Upper Palaeolithic Moravia was an important source of raw materials and a hub for gathering other materials and information from concrete supply zones, while others were neglected.
SESTA/FOSTA as de Facto Hate Policy: Combatting Carceral Investments and Uplifting Community-Based Solutions
Authors: Fuentes Kimberly , Levitt Lauren , Soriano Kimberly , Rowland Alisson , Wit Natasha 
Published: January 2025

Abstract
Introduction
Sex workers overlap demographically with individuals who are pushed into informal economies due to their marginalized identities. Although policies increasing the criminalization of sex work are not regarded as hate politics, we argue that these policies are de facto hate policies against LGBTQ + communities and other marginalized groups.

Methods
We utilize a literature review of nine empirical studies (2018–2023) on the effects of SESTA/FOSTA, a sex worker hate policy, as well as 25 interviews from a 2022 community-based study on the effects of California Senate Bill 233 (SB233), which decriminalized condom possession.

Results
SESTA/FOSTA harmed sex workers by reducing their income, restricting access to safety and screening resources, increasing the risk of exploitation and violence, and removing online spaces for community building and political organizing. Moreover, marginalized sex workers felt these effects most keenly. The SB233 interviews further revealed that condom possession was utilized as a means for law enforcement to harass trans women through pervasive harassment, deadnaming, and forcing sexual encounters with the threat of violence and jail time.

Conclusions
SESTA/FOSTA reveals how policies increasing the criminalization of sex workers also hate policies against marginalized groups. However, policies reducing the criminalization of sex workers, such as SB233, may be ineffective without community involvement. For this reason, we recommend community-based policies like SB357, which repealed loitering with intent.

Policy Implications
Hate politics increase carceral investments, leading to police harassment and surveillance of marginalized groups. We recommend community-led policy suggestions as an alternative.
Behavioral Aspects of Population Mobility Following a CBRN Event and Their Implications for Economic Consequence Analysis
Authors: Rose Adam , Djavadi Bess 
Published: January 2025

Abstract
Chemical, biological, radiological, and nuclear (CBRN) events can take a catastrophic toll on human life, the environment, and the economy. This article first presents the beginnings of a framework for the analysis of behavioral aspects of population mobility in the aftermath of a CBRN event in terms of four phases: quarantine, evacuation, resettlement, and return. Population movements are often omitted from economic consequence analyses because of the difficulty of conceptualizing and estimating them. Through a synthesis of the literature in the context of our analytical framework, we provide estimates of the drivers of important dimensions of population mobility relating to compliance, geography, and timing for each major threat type. We also provide an assessment of error bounds on these estimates. Our findings indicate that omission of various dimensions of population mobility can lead to the underestimation of economic consequences of CBRN events by one or two orders of magnitude. The analysis is intended to point out the relative sensitivities of bottom-line economic impacts to the various population mobility dimensions, so as to guide researchers undertaking this estimation and to help prioritize future research on reducing uncertainties in the direction of drivers that are the most impactful.