bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poly‐(Imidazolium‐Methylene) Chloride Mediated Self‐Assembly Strategy to Modulate Electronic Structure of Carbon Nitride for Enhanced Visible‐Light Photocatalytic Hydrogen Evolution
Authors: Zhang Xue , Yu Weiwei W. , Wang Guanchao C. , Zhao Zhongkui K. 
Published: February 2023

AbstractAs an attractive metal‐free conjugated polymer, graphitic carbon nitride (g‐C3N4) has attracted extensive attention in the field of solar energy conversion and storage as a visible light responsive hydrogen evolution. However, the photocatalytic efficiency of g‐C3N4 still has great room for improvement. Herein, a highly efficient visible‐light‐driven okra‐like tubular g‐C3N4photocatalyst (TCNMCA‐PImM) was synthesized via pyrolysis of a poly‐(imidazolium‐methylene) chloride (PImM)‐mediated molecular assembly prepared by a hydrothermal process of a solution containing PImM, melamine, and KOH, in which PImM acts as an electronic structure regulator owing to its strong hydrogen bond, π‐π interaction, and van der Waals force. On the basis of maintaining tri‐s‐triazine structure, the increase of graphitic N promotes the separation and transfer efficiency of photogenerated electrons and holes through the electron structure adjustment. The photocatalyst displays the notably promoted photocatalytic performance for H2 generation under visible‐light illumination. The optimized photocatalyst shows 1902 μmol h−1 g−1 of hydrogen evolution rate, which is 25.7 times higher than that of bulk g‐C3N4. The developed polymeric carbon nitride with unique geometric structure and electronic properties can be extended to other applications like CO2 capture for carbon neutralization strategy.
Genetic diversity and population structure of snap bean (Phaseolus vulgaris L.) from China revealed by microsatellite markers
Authors: Hao Junjie , Song Fengjing , Cui Xiao , Hua Zeke , Zhu TongDan , Wu Zhuobin , Wang Junwei , Chen Mingli , Zhang Xiaoyan 
Published: February 2023

AbstractSnap bean (Phaseolus vulgaris L.) is the vegetable form of common bean, and regarded as one of the most important and commonly consumed products in the world. In this study, 221 snap bean core accessions mostly from China were characterized the genetic diversity, gene pool identity, and relationships using 30 microsatellite markers, and concurrently evaluated for phenotype traits and phaseolin patterns. A total of 140 alleles were detected with an average of 4.67 per locus. The polymorphic information content ranged from 0.215 to 0.823, with an average of 0.488. Nei's genetic distances between accessions ranged from 0 to 0.9999, with an average of 0.6143. In those Chinese snap beans, structure analysis proved the existence of a high proportion of hybrid accessions except for identification of Andean and Mesoamerican gene pools. Neighbor‐joining clustering and principal coordinate analysis based microsatellite markers were similar in explaining the extent of diversity with both revealed Andean and Mesoamerican gene pools, which were divided into seven subgroups. Four of those subgroups, including one arising from introgression, were identified as belonging to the Andean gene pool, which likely represented Nueva Granada and Peru races. Other three subgroups were identified as belonging to the Mesoamerican gene pool, which likely represented the Mesoamerican race, owing to their close association with the control genotype. The diversity index of the qualitative traits was 0.80 to 1.88, with the average value of 1.20, while the diversity of the quantitative traits was ranked as 100‐seed weight (H′ = 1.98) > pod length (H′ = 1.90). Six principal components explained 69.13% of the total variation. Eight phaseolin patterns were identified in the 221 accessions. This study demonstrated the gene pool, as well as geographical, diversity of snap bean germplasms in China. The substantial diversity level is important for the utilization and conservation of snap bean, as well as future breeding programs.
Systematic design and prototyping of a low‐cost passive UHF‐RFID transponder
Authors: Kommey Benjamin , Addo Ernest Ofosu , Tamakloe Elvis 
Published: February 2023

AbstractThis paper presents a methodical design and prototyping of a passive European ultra‐high frequency (UHF) band radio frequency identification (RFID) transponder. The transponder has a 70 × 17 × 0.3 mm3 copper antenna whose design is based on the folded dipole architecture and utilizes techniques such as meandering and end loading to match a Texas Instruments (TI) UHF‐RFID chip through a T‐match feeding network. The tag's simulated and measured performances indicate good coverage of the entire UHF band with a return loss better than 10 dB. The transponder was then fabricated using inexpensive off‐the‐shelf materials and its performance was tested. The proposed tag achieved good gain, read range, and cost efficiency when compared with current folded dipole antennas and can be easily adapted for various applications such as supply chain, access or security, and vehicle identification.
What is the effect of a brief intervention to promote physical activity when delivered in a health care setting? A systematic review
Authors: Green Emily T. , Cox Narelle S. , Arden Clare M. , Warren Cathy J. , Holland Anne E. 
Published: February 2023

AbstractIssue AddressedWhat are the effects of a brief intervention to promote physical activity (PA) delivered in a health care setting other than primary care?MethodsMEDLINE, EMBASE, CINAHL and PsycINFO were used to identify randomised controlled trials which evaluated the effect of brief interventions to increase PA, delivered in a health care setting. Review outcomes included subjectively or objectively measured PA, adherence to prescribed interventions, adverse events, health‐related quality of life, self‐efficacy and stage of change in relation to PA. Where possible, clinically homogenous studies were combined in a meta‐analysis.ResultsTwenty‐five eligible papers were included. Brief counselling interventions were associated with increased PA compared to control, for both self‐reported PA (mean difference 34 minutes/week, 95% confidence intervals [95% CI] 9‐60 minutes), and pedometer (MD 1541 steps/day, 95% CI 433‐2649) at medium term follow up.ConclusionOur findings suggest that some brief interventions to increase PA, delivered in the health care setting, are effective at increasing PA in the medium term. There is limited evidence for the long‐term efficacy of such interventions. The wide variation in types of interventions makes it difficult to determine which intervention features optimize outcomes.So What?Brief counselling interventions delivered in a health care setting may support improved PA. Clinicians working in health care settings should consider the implementation of brief interventions to increase PA in vulnerable patient groups, including older adults and those with chronic illness.
Automated knee osteoarthritis severity classification using three‐stage preprocessing method andVGG16architecture
Authors: Saini Deepak , Khosla Ashima , Chand Trilok , Chouhan Devendra K. , Prakash Mahesh 
Published: February 2023

AbstractAs a nutshell, an early diagnosis of Knee Osteoarthritis (KOA) enhances the likelihood of an individual receiving treatment at its onset and prevents joint replacement surgery. Computer‐Aided‐Diagnosis (CAD) from the radiograph images have gained a wide‐spread attention in automated grading of KOA severity. But radiograph images have certain limitations, such as presence of too much noise and uneven contrast distribution across the image that impacts the accuracy and reliability of CAD systems. Therefore, a novel three‐stage pre‐processing method has been proposed using a combination of different techniques applied at sequential stages such as noise‐reduction using gaussian‐filter, normalization using pixel‐centering method, and balanced contrast enhancement technique. A transfer‐learning based VGG16 architecture has been used for severity classification. Our classification framework outperforms the existing state‐of‐the‐art methods achieving an excellent accuracy of 89.95\%. Therefore, our system can be used by the radiologists and physicians as a decision‐support tool in their daily diagnosis procedure.
Advances in thermal‐related analysis techniques for solid‐state lithium batteries
Authors: Wang Jianan , Yang Kai , Sun Shiyi , Ma Qianyue , Yi Gong , Chen Xin , Wang Ze , Yan Wei , Liu Xinhua , Cai Qiong , Zhao Yunlong 
Published: February 2023

AbstractSolid‐state lithium batteries (SSLBs) have been broadly accepted as a promising candidate for the next generation lithium‐ion batteries (LIBs) with high energy density, long duration, and high safety. The intrinsic non‐flammable nature and electrochemical/thermal/mechanical stability of solid electrolytes are expected to fundamentally solve the safety problems of conventional LIBs. However, thermal degradation and thermal runaway could also happen in SSLBs. For example, the large interfacial resistance between solid electrolytes and electrodes could aggravate the joule heat generation; the anisotropic thermal diffusion could trigger the uneven temperature distribution and formation of hotspots further leading to lithium dendrite growth. Considerable research efforts have been devoted to exploring solid electrolytes with outstanding performance and harmonizing interfacial incompatibility in the past decades. There have been fewer comprehensive reports investigating the thermal reaction process, thermal degradation, and thermal runaway of SSLBs. This review seeks to highlight advanced thermal‐related analysis techniques for SSLBs, by focusing particularly on multiscale and multidimensional thermal‐related characterization, thermal monitoring techniques such as sensors, thermal experimental techniques imitating the abuse operating condition, and thermal‐related advanced simulations. Insightful perspectives are proposed to bridge fundamental studies to technological relevance for better understanding and performance optimization of SSLBs.image
Fluorescent polymer markers photoconvertible with a 532 nm laser for individual cell labeling
Authors: Demina P. A. , Sindeeva O. A. , Abramova A. M. , Saveleva M. S. , Sukhorukov G. B. , Goryacheva I. Y. 
Published: February 2023

AbstractFluorescent photoconvertible materials and molecules have been successfully exploited as bioimaging markers and cell trackers. Recently, the novel fluorescent photoconvertible polymer markers have been developed that allow the long‐term tracking of individual labeled cells. However, it is still necessary to study the functionality of this type of fluorescent labels for various operating conditions, in particular for commonly used discrete wavelength lasers. In this article, the photoconversion of fluorescent polymer labels with both pulsed and continuous‐wave lasers with 532 nm‐irradiation wavelength, and under different laser power densities were studied. The photoconversion process was described and its possible mechanism was proposed. The peculiarities of fluorescent polymer capsules performance as an aqueous suspension and as a single capsule were described. We performed the successful nondestructivity marker photoconversion inside RAW 264.7 monocyte/macrophage cells under continuous‐wave laser with 532 nm‐irradiation wavelength, showing prospects of these fluorescent markers for long‐term live cell labeling.
Longitudinal change of serum inter‐alpha‐trypsin inhibitor heavy chain H4, and its correlation with inflammation, multiorgan injury, and death risk in sepsis
Authors: Zhao Xiangwang , Guo Yong , Li Lingyu , Li Yusheng 
Published: February 2023

AbstractBackgroundInter‐alpha‐trypsin inhibitor heavy chain H4 (ITIH4) inhibits infection‐induced inflammation and multiorgan injury through several methods. The present study aimed to estimate the association of serum ITIH4 with inflammatory cytokines, multiorgan injury, and death risk in sepsis patients.MethodsSerum samples were collected to detect ITIH4 by enzyme‐linked immunosorbent assay in 127 sepsis patients at admission (baseline), day (D)1, D3, and D7 after admission, as well as in 30 healthy controls (HCs). Additionally, 28‐day mortality was recorded in sepsis patients.ResultsITIH4 was reduced in sepsis patients versus HCs (median [interquartile range]: 147.9 [78.2–208.8] vs. 318.8 [237.2–511.4] ng/ml) (p < 0.001). In sepsis patients, ITIH4 was associated with the absence of cardiovascular and cerebrovascular disease history (p = 0.021). Additionally, ITIH4 was negatively correlated with tumor necrosis factor‐α (p < 0.001), interleukin (IL)‐1β (p < 0.001), IL‐6 (p = 0.019), IL‐17A (p = 0.002), and C‐reactive protein (p = 0.001), but positively related to IL‐10 (p = 0.007). Moreover, ITIH4 was also inversely associated with Acute Physiology and Chronic Health Evaluation II score (p = 0.002), Sequential Organ Failure Assessment (SOFA) score (p < 0.001), SOFA‐respiratory system score (p = 0.023), and SOFA‐renal system score (p = 0.007). Interestingly, ITIH4 gradually increased from baseline to D7 (p < 0.001); besides, ITIH4 at baseline (p = 0.009), D1 (p = 0.002), D3 (p < 0.001), and D7 (p = 0.015) were all decreased in sepsis deaths versus sepsis survivors.ConclusionSerum ITIH4 is raised from baseline to D7 after disease onset, and it reflects the reduction of systemic inflammation, disease severity, and 28‐day mortality for sepsis. However, further verification is required.
Gender and discouraged borrowers: Evidence from India
Authors: Ghosh Saibal 
Published: February 2023

AbstractUsing cross‐section data on small and medium enterprises (SMEs), the paper examines the importance of gender on discouraged borrowers in India. We distinguish the role of women across various capacities, such as owner, manager and owner‐manager. Controlling for potential endogeneity, the findings indicate that firms with women managers and those where women perform dual roles are more likely to be discouraged from borrowing. Furthermore, we show that interest rates and procedural complexities to be the key reasons that inhibit borrowing. Robustness tests lend credence to these findings.
Discovery of Isojacareubin as a covalent inhibitor of SARS‐CoV‐2 main protease using structural and experimental approaches
Authors: Khan Abbas , Heng Wang , Imran Kashif , Zhu Guanghao , Ji Jun , Zhang Yani , Guan Xiaoqing , Ge Guangbo , Wei Dong‐Qing 
Published: February 2023

AbstractThe ongoing pandemic with the emergence of immune evasion potential and, particularly, the current omicron subvariants intensified the situation further. Although vaccines are available, the immune evasion capabilities of the recent variants demand further efficient therapeutic choices to control the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic. Hence, considering the necessity of the small molecule inhibitor, we target the main protease (3CLpro), which is an appealing target for the development of antiviral drugs against SARS‐CoV‐2. High‐throughput molecular in silico screening of South African natural compounds database reported Isojacareubin and Glabranin as the potential inhibitors for the main protease. The calculated docking scores were reported to be −8.47 and −8.03 kcal/mol, respectively. Moreover, the structural dynamic assessment reported that Isojacareubin in complex with 3CLpro exhibit a more stable dynamic behavior than Glabranin. Inhibition assay indicated that Isojacareubin could inhibit SARS‐CoV‐2 3CLpro in a time‐ and dose‐dependent manner, with half maximal inhibitory concentration values of 16.00 ± 1.35 μM (60 min incubation). Next, the covalent binding sites of Isojacareubin on SARS‐CoV‐2 3CLpro was identified by biomass spectrometry, which reported that Isojacareubin can covalently bind to thiols or Cysteine through Michael addition. To evaluate the inactivation potency of Isojacareubin, the inactivation kinetics was further investigated. The inactivation kinetic curves were plotted according to various concentrations with gradient‐ascending incubation times. The KI value of Isojacareubin was determined as 30.71 μM, whereas the Kinact value was calculated as 0.054 min−1. These results suggest that Isojacareubin is a covalent inhibitor of SARS‐CoV‐2 3CLpro.
RIMeta: An R shiny tool for estimating the reference interval from a meta‐analysis
Authors: Jiang Ziren , Cao Wenhao , Chu Haitao , Bazerbachi Fateh , Siegel Lianne 
Published: February 2023

AbstractA reference interval, or an interval in which a prespecified proportion of measurements from a healthy population are expected to fall, is used to determine whether a person's measurement is typical of a healthy individual. For a specific biomarker, multiple published studies may provide data collected from healthy participants. A reference interval estimated by combining the data across these studies is typically more generalizable than a reference interval based on a single study. Methods for estimating reference intervals from random effects meta‐analysis and fixed‐effects meta‐analysis have been recently proposed and implemented using R software. We present an R Shiny tool, RIMeta, implementing these methods, which allows users not proficient in R to estimate a reference interval from a meta‐analysis using aggregate data (mean, standard deviation, and sample size) from each study. RIMeta (https://cers.shinyapps.io/RIMeta/) provides users a convenient way to estimate a reference interval from a meta‐analysis and to generate the reference interval plot to visualize the results. The use of this web‐based R Shiny tool does not require the installation of R or any background knowledge of programming. We explain all functions of the R Shiny tool and illustrate how to use it with a real data example.
Differences in pharyngeal swallow event timing: Healthy aging, Parkinson disease, and amyotrophic lateral sclerosis
Authors: Gandhi Pooja , Plowman Emily K. , Steele Catriona M. 
Published: February 2023

AbstractObjectiveThe pharyngeal phase of swallowing involves a coordinated sequence of events. Event durations may be prolonged in people with Parkinson disease (PwPD), and amyotrophic lateral sclerosis (PwALS); however, the cumulative effect of these changes is unexplored. We compared event latencies relative to hyoid burst (HYB) (time zero) to understand differences in deglutatory event timing. We hypothesized PwPD and PwALS would display similarly prolonged cumulative pharyngeal phase durations compared to healthy controls, with greater prolongations with increasing bolus viscosity.MethodWe retrospectively evaluated videofluoroscopic data of healthy adults (n = 78), PwPD (n = 17), and PwALS (n = 20). Participants swallowed 15 boluses of 20% (w/v) barium across five liquid consistencies. Paired raters evaluated nine deglutitive events using the ASPEKT method. Latencies were plotted by consistency relative to HYB and compared across cohorts using Mann–Whitney U tests (p ≤ .05). Cohen's d was calculated for all statistically significant results to determine effect size.ResultsIn PwPD, significantly prolonged latencies were observed on thin liquid boluses compared to healthy controls. Latencies to all post‐HYB events were significantly prolonged except for maximum upper esophageal sphincter distension. In PwALS, significantly prolonged latencies for events preceding and following HYB were noted on all consistencies compared to healthy controls and PwPD.ConclusionIn PwPD, event latencies for multiple components of the swallowing sequence were prolonged culminating in overall prolongation of the pharyngeal phase on thin liquid. A similar pattern, but with significantly greater prolongation, was seen in the PwALS, and extended to swallows of all liquid consistencies.
Patterns in sources and forms of nitrogen in a large eutrophic lake during a cyanobacterial harmful algal bloom
Authors: Kharbush Jenan J. , Robinson Rebecca S. , Carter Susan J. 
Published: February 2023

AbstractWestern Lake Erie experiences an annual, toxic cyanobacterial harmful algal bloom (cyanoHAB), primarily caused by excess anthropogenic inputs of nitrogen (N) and phosphorous (P). Because the non‐N fixing cyanobacteria species Microcystis dominates these blooms, N availability is hypothesized to play a central role in cyanoHAB progression, as well as production of the N‐rich toxin microcystin. Many previous studies focused on nitrate because it is the most abundant N substrate during bloom initiation. However, recent work implicated reduced N substrates like ammonium and dissolved organic N (DON) in promoting greater bloom biomass and longevity. To examine the relative importance of oxidized and reduced N substrates to phytoplankton during different bloom stages, we measured concentrations and natural abundance δ15N isotope values of dissolved N substrates and phytoplankton biomass throughout the entirety of the 2020 cyanoHAB in Western Lake Erie. The results provide the first data on DON dynamics and composition in Western Lake Erie, and suggest that phytoplankton, including Microcystis, likely relied on N regenerated from the DON pool in later bloom stages. In addition, the stable isotope data confirm the importance of nitrate delivered via the Maumee River to cyanobacterial growth and toxin production.
Relationship (breakup) reminders drive online advertising effectiveness
Authors: Tan Ser Zian , Bandyopadhyay Argho , Septianto Felix 
Published: February 2023

AbstractThis research investigates the effect of using relationship (breakup) reminders in advertising on click‐through rates. While previous research has found that relationship reminders may backfire when consumers lack or no longer have certain social relationships (e.g., close friends, family, or a romantic partner), the authors propose that ad messages encouraging consumers after a relationship breakup, as compared with simply reminding them of a current relationship, will increase consumer perceptions of social support from a brand. This is because consumers may find readily available social support from a brand when coping with a relationship breakup. This, in turn, will pique their interest in the brand and prompt them to seek more information. Across two experimental studies, the results show that consumers who are exposed to ad messages encouraging them after a relationship breakup (vs. reminding them of a current relationship) feel greater social support, leading to higher click‐through rates. Furthermore, this effect is moderated by destiny beliefs. These findings contribute to the implicit theories of relationships and the consumer–brand relationship literature by demonstrating how destiny beliefs are important to understanding consumer responses to advertisements utilizing relationship (breakup) messages. Furthermore, the findings can benefit marketers when designing relationship reminders in online advertising.