bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive autophagy reprogramming in Schwann cells during peripheral demyelination
Authors: Jo Young Rae , Oh Yuna , Kim Young Hee , Shin Yoon Kyung , Kim Hye Ran , Go Hana , Shin Jaekyoon , Park Hye Ji , Koh Hyongjong , Kim Jong Kuk , Shin Jung Eun , Lee Kyung Eun , Park Hwan Tae 
Published: January 2023

AbstractThe myelin sheath is an essential structure for the rapid transmission of electrical impulses through axons, and peripheral myelination is a well-programmed postnatal process of Schwann cells (SCs), the myelin-forming peripheral glia. SCs transdifferentiate into demyelinating SCs (DSCs) to remove the myelin sheath during Wallerian degeneration after axonal injury and demyelinating neuropathies, and macrophages are responsible for the degradation of myelin under both conditions. In this study, the mechanism by which DSCs acquire the ability of myelin exocytosis was investigated. Using serial ultrastructural evaluation, we found that autophagy-related gene 7-dependent formation of a “secretory phagophore (SP)” and tubular phagophore was necessary for exocytosis of large myelin chambers by DSCs. DSCs seemed to utilize myelin membranes for SP formation and employed p62/sequestosome-1 (p62) as an autophagy receptor for myelin excretion. In addition, the acquisition of the myelin exocytosis ability of DSCs was associated with the decrease in canonical autolysosomal flux and was demonstrated by p62 secretion. Finally, this SC demyelination mechanism appeared to also function in inflammatory demyelinating neuropathies. Our findings show a novel autophagy-mediated myelin clearance mechanism by DSCs in response to nerve damage.
Talar OsteoPeriostic grafting from the Iliac Crest (TOPIC) for lateral osteochondral lesions of the talus: operative technique
Authors: Dahmen Jari , Rikken Quinten G. H. , Kerkhoffs Gino M. M. J. , Stufkens Sjoerd A. S. 
Published: January 2023

Abstract
Objective
To provide a natural scaffold, good quality cells, and growth factors to facilitate replacement of the complete osteochondral unit with matching talar curvature for large osteochondral lesions of the lateral talar dome.

Indications
Symptomatic primary and non-primary lateral osteochondral lesions of the talus not responding to conservative treatment. The anterior–posterior or medial–lateral diameter should exceed 10 mm on computed tomography (CT) for primary lesions; for secondary lesions, there are no size limitations.

Contraindications
Tibiotalar osteoarthritis grade III, malignancy, active infectious ankle joint pathology, and hemophilic or other diffuse arthropathy.

Surgical technique
Anterolateral arthrotomy is performed after which the Anterior TaloFibular Ligament (ATFL) is disinserted from the fibula. Additional exposure is achieved by placing a Hintermann distractor subluxating the talus ventrally. Thereafter, the osteochondral lesion is excised in toto from the talar dome. The recipient site is micro-drilled in order to disrupt subchondral bone vessels. Thereafter, the autograft is harvested from the ipsilateral iliac crest with an oscillating saw, after which the graft is adjusted to an exactly fitting shape to match the extracted lateral osteochondral defect and the talar morphology as well as curvature. The graft is implanted with a press-fit technique after which the ATFL is re-inserted followed by potential augmentation with an InternalBrace™ (Arthrex, Naples, FL, USA).

Postoperative management
Non-weightbearing cast for 6 weeks, followed by another 6 weeks with a walking boot. After 12 weeks, a computed tomography (CT) scan is performed to assess consolidation of the inserted autograft. The patient is referred to a physiotherapist.
Concepts, utilization, and perspectives on the Dutch Nationwide Trauma registry: a position paper
Authors: Hoepelman R. J. , Driessen M. L. S. , de Jongh M. A. C. , Houwert R. M. , Marzi I. , Lecky F. , Lefering R. , van de Wall B. J. M. , Beeres F. J. P. , Dijkgraaf M. G. W. , Groenwold R. H. H. , Leenen L. P. H. 
Published: January 2023

AbstractOver the last decades, the Dutch trauma care have seen major improvements. To assess the performance of the Dutch trauma system, in 2007, the Dutch Nationwide Trauma Registry (DNTR) was established, which developed into rich source of information for quality assessment, quality improvement of the trauma system, and for research purposes. The DNTR is one of the most comprehensive trauma registries in the world as it includes 100% of all trauma patients admitted to the hospital through the emergency department. This inclusive trauma registry has shown its benefit over less inclusive systems; however, it comes with a high workload for high-quality data collection and thus more expenses. The comprehensive prospectively collected data in the DNTR allows multiple types of studies to be performed. Recent changes in legislation allow the DNTR to include the citizen service numbers, which enables new possibilities and eases patient follow-up. However, in order to maximally exploit the possibilities of the DNTR, further development is required, for example, regarding data quality improvement and routine incorporation of health-related quality of life questionnaires. This would improve the quality assessment and scientific output from the DNTR. Finally, the DNTR and all other (European) trauma registries should strive to ensure that the trauma registries are eligible for comparisons between countries and healthcare systems, with the goal to improve trauma patient care worldwide.
Impact of peripapillary staphylomas on the vascular and structural characteristics in myopic eyes: a propensity score matching analysis
Authors: Nie Fen , Zhang Lurong , Cao Mengdan , Zhou Dengming , Liu Ke , Ouyang Junyi , Luo Lijia , Zhu Ruiling , Liu Shaosan , Duan Xuanchu 
Published: January 2023

Abstract

Purpose
To apply propensity score matching to evaluate the impact of peripapillary staphylomas (PPS) on vascular and structural characteristics in the myopic eyes.

Methods
This was a prospective, cross-sectional study. Forty-one control eyes and 41 eyes with PPS were analyzed. The eyes were selected using propensity score matching analysis based on the age and axial length. All subjects underwent ophthalmologic examinations for assessing vessel and structure parameters using swept-source optical coherence tomography (SS-OCT), OCT angiography, color fundus photography, and ocular biometry.

Results
As compared with control eyes, the eyes with PPS had shallower anterior chamber depth (3.61 ± 0.24 mm vs 3.77 ± 0.24 mm, P = 0.004), higher intraocular pressure (IOP) (16.59 ± 2.88 mmHg vs 14.53 ± 2.45 mmHg, P = 0.002), and higher myopic spherical equivalent (− 11.52 ± 3.22D vs − 9.88 ± 2.20D, P = 0.009). while corneal curvature and lens thickness between the two groups were not statistically different. Compared with control eyes, increased macular deep vessel density, reduced macular choriocapillaris and radial peripapillary capillary, and thinning retinal layer, ganglion cell complex, choroidal layer as well as the superior and inferior peripapillary retinal nerve fiber layer were observed in eyes with PPS, apart from larger disc area, parapapillary atrophy area, and degree of disc rotation. Logistic regression analysis revealed that the IOP (P = 0.046), disc rotation (P = 0.003), and average peripapillary choroidal thickness (P = 0.009) were associated with the presence of PPS.

Conclusion
Close association of PPS with exacerbation of myopia and anatomical alterations was observed which not only affected the eye posterior segment but also the anterior segments. We further identified significant reductions in the radial peripapillary capillary and macular choroidal perfusion with the increase in macular deep retinal flow blood of myopic eyes with PPS. Higher IOP, thinner peripapillary choroidal thickness, and rotated optic disc were risk factors for the presence of PPS.
Mapping the primate thalamus: historical perspective and modern approaches for defining nuclei
Authors: García-Cabezas Miguel Ángel , Pérez-Santos Isabel , Cavada Carmen 
Published: January 2023

AbstractThe primate thalamus has been subdivided into multiple nuclei and nuclear groups based on cytoarchitectonic, myeloarchitectonic, connectional, histochemical, and genoarchitectonic differences. Regarding parcellation and terminology, two main schools prevailed in the twentieth century: the German and the Anglo-American Schools, which proposed rather different schemes. The German parcellation and terminology has been mostly used for the human thalamus in neurosurgery atlases; the Anglo-American parcellation and terminology is the most used in experimental research on the primate thalamus. In this article, we review the historical development of terminological and parcellation schemes for the primate thalamus over the last 200 years. We trace the technological innovations and conceptual advances in thalamic research that underlie each parcellation, from the use of magnifying lenses to contemporary genoarchitectonic stains during ontogeny. We also discuss the advantages, disadvantages, and practical use of each parcellation.
Anastomotic perfusion assessment with indocyanine green in robot-assisted low-anterior resection, a multicenter study of interobserver variation
Authors: Larsen Pernille O. , Nerup Nikolaj , Andersen Jesper , Dohrn Niclas , Klein Mads Falk , Brisling Steffen , Salomon Soren , Andersen Per V. , Möller Soren , Svendsen Morten B. S. , Rahr Hans B. , Iversen Lene H. , Gögenur Ismail , Qvist Niels , Ellebaek Mark B. 
Published: January 2023

Abstract
Background
Securing sufficient blood perfusion to the anastomotic area after low-anterior resection is a crucial factor in preventing anastomotic leakage (AL). Intra-operative indocyanine green fluorescent imaging (ICG-FI) has been suggested as a tool to assess perfusion. However, knowledge of inter-observer variation among surgeons in the interpretation of ICG-FI is sparse. Our primary objective was to evaluate inter-observer variation among surgeons in the interpretation of bowel blood-perfusion assessed visually by ICG-FI. Our secondary objective was to compare the results both from the visual assessment of ICG and from computer-based quantitative analyses of ICG-FI between patients with and without the development of AL.

Method
A multicenter study, including patients undergoing robot-assisted low anterior resection with stapled anastomosis. ICG-FI was evaluated visually by the surgeon intra-operatively. Postoperatively, recorded videos were anonymized and exchanged between centers for inter-observer evaluation. Time to visibility (TTV), time to maximum visibility (TMV), and time to wash-out (TWO) were visually assessed. In addition, the ICG-FI video-recordings were analyzed using validated pixel analysis software to quantify blood perfusion.

Results
Fifty-five patients were included, and five developed clinical AL. Bland–Altman plots (BA plots) demonstrated wide inter-observer variation for visually assessed fluorescence on all parameters (TTV, TMV, and TWO). Comparing leak-group with no-leak group, we found no significant differences for TTV: Hazard Ratio; HR = 0.82 (CI 0.32; 2.08), TMV: HR = 0.62 (CI 0.24; 1.59), or TWO: HR = 1.11 (CI 0.40; 3.11). In the quantitative pixel analysis, a lower slope of the fluorescence time-curve was found in patients with a subsequent leak: median 0.08 (0.07;0.10) compared with non-leak patients: median 0.13 (0.10;0.17) (p = 0.04).

Conclusion
The surgeon’s visual assessment of the ICG-FI demonstrated wide inter-observer variation, there were no differences between patients with and without AL. However, quantitative pixel analysis showed a significant difference between groups.

Trial Registration
ClinicalTrials.gov Identifier: NCT04766060.
Systemic oncological treatments in patients with advanced pancreatic cancer: a scoping review and evidence map
Authors: Salazar Josefina , Bracchiglione Javier , Acosta-Dighero Roberto , Meza Nicolas , Meade Adriana-G. , Quintana María Jesús , Requeijo Carolina , Rodríguez-Grijalva Gerardo , Santero Marilina , Selva Anna , Solà Ivan , Bonfill Xavier ,   Appropriateness of Systemic Oncological Treatments for Advanced Cancer (ASTAC) Research Group, Salas Karla , Antequera Alba , Auladell-Rispau Ariadna , Urrútia Gerard , Meinardi Pamela , Irassar Juan , Simancas Daniel , Dorantes Rosario , Merchán Angela , Cantero Yahveth , Hernandez Edgar , Sugrañes Miguel 
Published: January 2023

Abstract
Purpose
To identify, describe, and organise currently available evidence regarding systemic oncological treatments (SOTs) (chemotherapy, targeted/biological therapies, and immunotherapy) compared to best supportive care (BSC) for patients with advanced pancreatic cancer (PC).

Methods
We conducted a scoping review and evidence mapping, adhering to PRISMA-ScR checklist. We searched MEDLINE, EMBASE, Cochrane Library, Epistemonikos, PROSPERO, and clinicaltrials.gov for eligible studies. We included systematic reviews (SRs), randomised controlled trials (RCTs), quasi-experimental, and observational studies evaluating SOTs compared to BSC or no treatment in patients with advanced PC. Two independent reviewers performed the screening process and data extraction. We developed evidence maps as an interactive visualization display, including the assessed interventions and outcomes.

Results
Of the 50,601 records obtained from our search, we included 43 studies: 2 SRs, 16 RCTs, 4 quasi-experimental studies, 20 observational studies, and 1 protocol for a quasi-experimental study. Forty-two studies reported survival-related outcomes and most favoured SOTs, while five reported toxicity and most favoured BSC. Other patient-centred outcomes, such as quality of life, were scarcely reported.

Conclusions
This study highlights the current evidence gaps in studies assessing treatments for patients with advanced PC, mainly the lack of reports of non-survival-related outcomes, pointing out research areas that need further attention to make better recommendations for these patients.
Two New Methods for Defining Shut-In Pressure in Hydraulic Fracturing Tests
Authors: Trinh Nghia Quoc , Hagen Simon Alexander , Strømsvik Helene , Larsen Trond , Grøv Eivind 
Published: January 2023

AbstractHydraulic fracturing is one of the most common methods to determine in situ rock stress. The interpretation of the shut-in pressure to determine the minor principal stress is an important element of this method, and many different methods to interpret shut-in pressure have been studied and developed throughout the years. Each method has its advantages and disadvantages. With more than 50 years of research and development within the rock stress measurement field, especially in HF, SINTEF has established two practical ways of defining shut-in pressure. These methods are independent and termed zero flow and water hammer. The zero flow method has been used by SINTEF in more than 130 projects over the last 30 years. The methods clearly differ from the other methods as they are based on singular events in the development of pressure/flow versus time which enables us to read the shut-in pressure directly during testing. In this paper, a comparison is made between different methods for interpretation of shut-in pressure, including 12 existing methods and the 2 SINTEF methods. Comprehensive laboratory tests were performed, and a field test was selected from SINTEF’s database for demonstration and comparison of the methods. The SINTEF methods have been developed mainly for use in hard rock environment where the rock is a jointed aquifer and with low permeability. The application of the two methods has traditionally been hydroelectric power development, different types of tunnel, and cavern projects, and also in mineral mining. The methods have not been used in deep petroleum applications such as oil wells or offshore in porous rock types.
Ex vivo and in vivo evaluation of transsphenoidal Liqoseal application to prevent cerebrospinal fluid leakage
Authors: Slot Emma M. H. , Colmer Nadia , Serra Carlo , Holzmann David , Regli Luca , van Doormaal Tristan P. C. 
Published: January 2023

Abstract

Background
Despite improvements in closure techniques by using a vital nasoseptal flap, the use of sealing materials, and improved neurosurgical techniques, cerebrospinal fluid (CSF) leak after transsphenoidal surgery still is a clinically relevant problem. Liqoseal® (Polyganics bv, Groningen, The Netherlands) is a CE-approved bioresorbable sealant patch for use as an adjunct to standard methods of cranial dural closure to prevent CSF leakage. This study aims to evaluate the application of Liqoseal in transsphenoidal surgery ex vivo and in vivo.

Methods
1. We created an ex vivo setup simulating the sphenoidal anatomy, using a fluid pump and porcine dura positioned on a conus with the anatomical dimensions of the sella to evaluate whether the burst pressure of Liqoseal applied to a bulging surface was above physiological intracranial pressure. Burst pressure was measured with a probe connected to dedicated computer software. Because of the challenging transsphenoidal environment, we tested in 4 groups with varying compression weight and time for the application of Liqoseal. 2. We subsequently describe the application of Liqoseal® in 3 patients during transsphenoidal procedures with intraoperative CSF leakage to prevent postoperative CSF leakage.

Results
1. Ex vivo: The overall mean burst pressure in the transsphenoidal setup was 231 (± 103) mmHg. There was no significant difference in mean burst pressure between groups based on application weight and time (p = 0.227). 2. In Vivo: None of the patients had a postoperative CSF leak. No nose passage problems were observed. One patient had a postoperative meningitis and ventriculitis, most likely related to preoperative extensive CSF leakage. Postoperative imaging did not show any local infection, swelling, or other device-related adverse effects.

Conclusions
We assess the use of Liqoseal® to seal a dural defect during an endoscopic transsphenoidal procedure as to be likely safe and potentially effective.
Atrophy in subcortical gray matter in adult patients with moyamoya disease
Authors: Zuo Zhiwei , Li Guo , Chen Ya , Qiao Penggang , Zhu Jing , Wang Peng , Wu Fa , Yu Hongmei , Jiang Yalan , Yang Jindou , Li Gongjie , Jiang Rui , Du Feizhou 
Published: January 2023

Abstract
Background
Acute cerebrovascular accidents, long-term hypoperfusion, and/or remote neuronal degeneration may lead to structural alterations in patients with moyamoya disease (MMD). This study sought to comprehensively investigate the distribution characteristics of subcortical gray matter volume and their correlations with angiographic changes in the intracranial artery in patients with MMD.

Method
One hundred forty-two patients with MMD and 142 age- and sex-matched healthy controls underwent 3-dimensional high-resolution structural magnetic resonance imaging. Volumes of subcortical gray matter and subregions of the hippocampus and amygdala were calculated, and the degree of stenosis/occlusion of intracranial arteries in patients with MMD was evaluated on MR angiography.

Results
Volume reductions in the thalamus, caudate, putamen, hippocampus, amygdala, pallidum, and nucleus accumbens were found in patients with MMD. Hippocampal subfields and amygdala subnuclei in patients with MMD showed distinct vulnerability, and morphological alterations in specific subregions were more obvious than in the whole hippocampus/amygdala. Volume loss in several subcortical areas was related to disease duration and intracranial arterial changes.

Conclusions
Our findings revealed structural alteration patterns of subcortical gray matter in MMD. The specific atrophy in subregions of the hippocampus and the amygdala suggested potential cognitive and affective impairments in MMD, which warrants further investigation. Chronic cerebral hemodynamic alterations in MMD may play a pivotal role in morphological changes in subcortical areas.
Stokes–Mueller polarization-based analysis of model SARS-CoV-2 virions
Authors: K U Spandana , Hunakunti Bhagesh Basavraj , Le Gratiet Aymeric , Gogoi Ankur , Mazumder Nirmal 
Published: January 2023

Abstract
Understanding the virology of the coronavirus at the structural level has gained utmost importance to overcome the constant and long-term health complications induced by them. In this work, the light scattering properties of SARS-CoV-2 of size 140 nm were simulated by using discrete dipole approximation (DDA) for two incident wavelengths 200 nm and 350 nm, respectively. Three different 3-dimensional (3D) models of SARS-CoV-2 corresponding to 15, 20, and 40 numbers of spike proteins on the viral capsid surface were constructed as target geometries for the DDA calculations. These models were assessed by employing Stokes–Mueller polarimetry to obtain individual polarization properties such as degree of polarization (DOP), degree of linear polarization (DOLP), and degree of circular polarization (DOCP). Irrespective of its spike numbers, all the coronavirus models were found to display higher DOP and DOCP values and negligibly small DOLP values for circularly polarized incident light, indicating the presence of chiral structures. On the other hand, the lack of understanding about the dependence of the Mueller matrix on its microstructural properties was overcome by transforming 16 Mueller elements into sub-matrices with specific structural and physical properties using Lu–Chipman-based Mueller matrix polar decomposition method. The obtained properties such as retardance, diattenuation, and depolarization were used for investigating the composition and microstructural information. The approach presented in this work has the potential to understand the virology of the coronavirus at the structural level and, therefore, will be beneficial in developing effective detection strategies by exploiting their characteristic electromagnetic scattering signatures.
A generic framework for representing and analyzing model concurrency
Authors: Zschaler Steffen , Bousse Erwan , Deantoni Julien , Combemale Benoit 
Published: January 2023

AbstractRecent results in language engineering simplify the development of tool-supported executable domain-specific modeling languages (xDSMLs), including editing (e.g., completion and error checking) and execution analysis tools (e.g., debugging, monitoring and live modeling). However, such frameworks are currently limited to sequential execution traces and cannot handle execution traces resulting from an execution semantics with a concurrency model supporting parallelism or interleaving. This prevents the development of concurrency analysis tools, like debuggers supporting the exploration of model executions resulting from different interleavings. In this paper, we present a generic framework to integrate execution semantics with either implicit or explicit concurrency models, to explore the possible execution traces of conforming models, and to define strategies for helping in the exploration of the possible executions. This framework is complemented with a protocol to interact with the resulting executions and hence to build advanced concurrency analysis tools. The approach has been implemented within the GEMOC Studio. We demonstrate how to integrate two representative concurrent meta-programming approaches (MoCCML/Java and Henshin), which use different paradigms and underlying foundations to define an xDSML’s concurrency model. We also demonstrate the ability to define an advanced concurrent omniscient debugger with the proposed protocol. The paper, thus, contributes key abstractions and an associated protocol for integrating concurrent meta-programming approaches in a language workbench, and dynamically exploring the possible executions of a model in the modeling workbench.