bluuebunny/crossref_metadata_2025_split huggingface dataset:
Schizencephaly diagnosed after an episode of seizure during labor: A case report
Authors: Paudel Kusum , Prasad Tanisha , Gyawali Prashant , Nepal Gaurav , Jaiswal Vikash 
Published: May 2023

AbstractSchizencephaly, an extremely rare anomaly of the cortex, is characterized by abnormal clefts in the cerebral cortex. Very often, this condition is diagnosed early in the childhood period but few instances exist in literature where schizencephaly‐associated seizures and hemiparesis have presented later in life too. Here, we report a rare case scenario of a lady in her late 30s who initially presented to us with obstetric concerns wherein schizencephaly remained an incidental finding despite the significantly large cortical cleft along with lobar holoprosencephaly and lissencephaly.
Porphyrins Anchored onto Colour Catcher®: Photoactive Material for the Conversion of Amines into Imines and Aldehydes into Carboxylic Acids
Authors: Damiano Caterina , Cavalleri Matteo , di Natale' Corrado , Paolesse Roberto , Gallo Emma 
Published: May 2023

AbstractA new photoactive material was obtained by the heterogenization of zinc(II) porphyrin onto cellulose‐based Colour Catcher® sheet. The so‐obtained Zn(porphyrin)@CC material performed very well in activating molecular oxygen in the photooxidative coupling of amines to imines and the photooxidation of aldehydes to corresponding acids in the presence of white light. The high eco‐compatibility of the solid support, the chemical stability of the photoactive material and the mild experimental conditions applied confer a very good sustainability to the procedure and open the doors to a larger employment of Colour Catcher®‐based porphyrin material in reactions mediated by light.
Cannabicitran: Its unexpected racemic nature and potential origins
Authors: Wood Jared S. , Gordon William H. , Morgan Jeremy B. , Williamson R. Thomas 
Published: May 2023

AbstractCannabicitran is a cannabinoid found in levels up to ~10% in commercial “purified” cannabidiol (CBD) extracts. The structure of this natural product was first reported more than 50 years ago. However, few studies have investigated cannabicitran or its origin despite the rapidly increasing interest in the use of cannabinoids for the treatment of a wide range of physiological conditions. Following on a recent detailed NMR and computational characterization of cannabicitran, our group initiated ECD and TDDFT studies aimed at unequivocally determining the absolute configuration of cannabicitran present inCannabis sativaextracts. To our surprise, we discovered the natural product was racemic, raising questions around its presumed enzymatic origin. Herein, we report the isolation and absolute configuration of (−)‐cannabicitran and (+)‐cannabicitran. Several possible scenarios for production of the racemate in the plant and/or during extract processing are discussed.
NTRK gene aberrations in triple‐negative breast cancer: detection challenges using IHC, FISH, RT‐PCR, and NGS
Authors: Zito Marino Federica , Buono Simona , Montella Marco , Giannatiempo Rosa , Messina Francesco , Casaretta Giovanni , Arpino Grazia , Vita Giulia , Fiorentino Francesco , Insabato Luigi , Sgambato Alessandro , Orditura Michele , Franco Renato , Accardo Marina 
Published: May 2023

AbstractTriple‐negative breast cancer (TNBC) is usually an aggressive disease with a poor prognosis and limited treatment options. The neurotrophic tyrosine receptor kinase (NTRK) gene fusions are cancer type‐agnostic emerging biomarkers approved by the Food and Drug Administration (FDA), USA, for the selection of patients for targeted therapy. The main aim of our study was to investigate the frequency of NTRK aberrations, i.e. fusions, gene copy number gain, and amplification, in a series of TNBC using different methods. A total of 83 TNBCs were analyzed using pan‐TRK immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), real‐time polymerase chain reaction (RT‐PCR), and RNA‐based next‐generation sequencing (NGS). Of 83 cases, 16 showed pan‐TRK positivity although no cases had NTRK‐fusions. Indeed, FISH showed four cases carrying an atypical NTRK1 pattern consisting of one fusion signal and one/more single green signals, but all cases were negative for fusion by NGS and RT‐PCR testing. In addition, FISH analysis showed six cases with NTRK1 amplification, one case with NTRK2 copy number gain, and five cases with NTRK3 copy number gain, all negative for pan‐TRK IHC. Our data demonstrate that IHC has a high false‐positive rate for the detection of fusions and molecular testing is mandatory; there is no need to perform additional molecular tests in cases negativity for NTRK by IHC. In conclusion, the NTRK genes are not involved in fusions in TNBC, but both copy number gain and amplification are frequent events, suggesting a possible predictive role for other NTRK aberrations.
A Phase 1, Open‐Label, Fixed‐Sequence, Drug–Drug Interaction Study of Zanubrutinib with Rifabutin in Healthy Volunteers
Authors: Tariq Bilal , Conto Stephanie , Cohen Aileen , Sahasranaman Srikumar , Ou Ying C. 
Published: May 2023

AbstractZanubrutinib is a second‐generation Bruton tyrosine kinase inhibitor that is primarily metabolized by CYP3A enzymes. Previous drug–drug interaction (DDI) studies have demonstrated that co‐administration of zanubrutinib with rifampin, a strong CYP3A inducer, reduces zanubrutinib plasma concentrations, potentially impacting activity. The impact of the co‐administration of zanubrutinib with less potent CYP3A inducers is unclear. This phase 1, open‐label, fixed‐sequence DDI study evaluated the pharmacokinetics, safety, and tolerability of zanubrutinib when co‐administered with steady‐state rifabutin, a known CYP3A inducer less potent than rifampin, in 13 healthy male volunteers (NCT04470908). Co‐administration of zanubrutinib with rifabutin resulted in a less than 2‐fold reduction of zanubrutinib exposures. Overall, zanubrutinib was well tolerated. The results of this study provide useful information for the evaluation of the DDI between rifabutin and zanubrutinib. In conjunction with safety and efficacy data from other clinical studies, these results will be taken into consideration to determine the appropriate dose recommendation of zanubrutinib when co‐administered with CYP3A inducers.
Simulation of the Influence Mechanism of Hydrothermal Modification on Magnesium Hydroxide
Authors: Shi Xiaoyan , Chen Hang , Sun Yuzhu , Song Xingfu 
Published: May 2023

AbstractTo overcome the drawbacks of strong polarity and easy agglomeration of ordinary magnesium hydroxide (MH), hydrothermal modification is customary applied to achieve its excellent dispersion as well as controllable morphology and particle size. In this paper, the influence mechanism of hydrothermal modification is elaborated from microstructure of MH. Structures and surface energy of crystal planes, affinity of water molecules for crystal planes, and crystal growth process are calculated by Materials Studio software. Furthermore, molecular dynamics simulations about solid–liquid interface model of MH and 1 mol L−1 NaOH solution at different temperatures are performed based on the theory of modified attachment energy model. The results indicate that (0 0 1) plane with the smallest surface energy has the strongest thermodynamic stability, equipping modified crystals with lamellar morphology and excellent dispersion. (0 0 1) plane cannot be dissolved easily because of the smallest affinity of water molecules. The magnesium atoms and hydroxyl groups on (1 0 1) plane dissolved are absorbed on (0 0 1) plane, resulting in the large value of I001/I101 in the X‐ray diffraction pattern. The relative growth rate of (1 0 1) plane R101 decreases with the increasing temperature, explaining why crystals become thicker with raising temperature.
Shaping a sustainable future: The impact of board gender diversity on clean energy use and the moderating role of environmental, social and governance controversies
Authors: Issa Ayman 
Published: May 2023

AbstractThis study investigates how gender‐diverse boards are related to the adoption of clean energy and examines whether environmental, social, and governance (ESG) controversies have an impact on this link. The study analyzes 2395 firm‐year observations from 13 European countries from 2006 to 2021. Drawing on the gender socialization theory and diversity theory, the research reveals a favorable effect of board gender diversity on a company's utilization of clean energy. It also demonstrates that ESG controversies play a significant role in moderating this relationship. Furthermore, the study affirms the critical mass theory by indicating that companies with at least three female board members exhibit a greater use of clean energy. The findings are robust to various methods, such as controlling for endogeneity problems, propensity score matching, sub‐sample analysis, and alternative econometric models. This study's implications are important for stakeholders, policymakers, and managers. It suggests that having a gender‐diverse board can increase the adoption of clean energy, benefiting a company's reputation and attractiveness to stakeholders. Policymakers can use these findings to design policies that encourage gender diversity on boards and achieve environmental goals, while managers can make informed decisions about board composition and clean energy adoption.
Therapeutic approach in heart failure with poor diuretic response: peripheral ultrafiltration vs. conventional treatment
Authors: López‐Vilella Raquel , Guerrero Cervera Borja , Sánchez‐Lázaro Ignacio , Donoso Trenado Víctor , Soldevila Orient Amparo , Devesa Such Ramón , Martínez Dolz Luis , Sánchez Pérez Pilar , Almenar Bonet Luis 
Published: May 2023

AbstractAimsPatients with heart failure (HF) admitted for decompensation often require high doses of intravenous diuretics. This study aims to analyse whether the use of peripheral ultrafiltration (UF) in patients hospitalized for acute HF with systemic‐predominant congestion results in better hydric control, renal protection, and reduction of hospital stay compared with conventional treatment.Methods and resultsThis study was a retrospective, comparative, single‐centre study of 56 patients admitted for HF with systemic congestion with a poor diuretic response after diuretic escalation. One group underwent peripheral UF (35 patients) and others were maintained on intense diuretic treatment (control group, 21 patients). The diuretic response and days of hospital stay were compared between and within groups. The baseline characteristics of both groups were similar: males with right ventricular failure and renal dysfunction. The inter‐group analysis showed that patients who received UF had better glomerular filtration rate (GFR; UF: 39.2 ± 18.2 vs. control: 28.7 ± 13.4 mL/min; P = 0.031) and higher diuresis (UF: 2184 ± 735 vs. control: 1335 ± 297 mL; P = 0.0001) at hospital discharge despite less need for diuretic drugs. Days of hospital stay were shorter in the UF group (UF: 11.7 ± 10.1 vs. control: 19.1 ± 14.4 days; P = 0.027). Intra‐group analysis showed that patients receiving UF improved GFR, increased diuresis, and reduced weight at discharge (P < 0.001), whereas patients on conventional treatment only experienced improved weight but worsening renal function at discharge.ConclusionsIn patients with acute HF with systemic congestion and diuretic resistance, UF compared with conventional treatment produces greater decongestion and renal protection, reduces the total diuretic load, and shortens the length of hospital stay.
Silver‐Catalyzed and Silver‐Promoted Reactions of Isocyanides
Authors: Wang Yeming , Zhang Chaoqun , Li Shizhe , Liu Lihui , Feng Xiaodong , Liu Gang 
Published: May 2023

AbstractIn recent years, the silver‐catalyzed and silver‐promoted isocyanide reactions have attracted much attention, due to its efficiency in the formation of diverse new bonds and good reaction selectivity. A series of highly useful linear or cyclic compounds have been constructed. In this review, the recent progress in this field is described in the sequence of synthesis of five‐membered heterocyclic compounds, synthesis of six‐membered heterocyclic compounds, synthesis of fused cyclic compounds as well as synthesis of linear nitrogen‐containing compounds.
A hierarchical Bayesian non‐asymptotic extreme value model for spatial data
Authors: Stolf Federica , Canale Antonio 
Published: May 2023

AbstractSpatial maps of extreme precipitation are crucial in flood prevention. With the aim of producing maps of precipitation return levels, we propose a novel approach to model a collection of spatially distributed time series where the asymptotic assumption, typical of the traditional extreme value theory, is relaxed. We introduce a Bayesian hierarchical model that accounts for the possible underlying variability in the distribution of event magnitudes and occurrences, which are described through latent temporal and spatial processes. Spatial dependence is characterized by geographical covariates and effects not fully described by the covariates are captured by spatial structure in the hierarchies. The performance of the approach is illustrated through simulation studies and an application to daily rainfall extremes across North Carolina (USA). The results show that we significantly reduce the estimation uncertainty with respect to state of the art techniques.
Maternal diet quality and nutrient intakes across preconception and pregnancy are not consistent with Australian guidelines: Results from the pilot BABY1000 study
Authors: Maneschi Katie , Geller Taryn , Collins Clare E. , Gordon Adrienne , Grech Allison 
Published: May 2023

AbstractBackground and objective: Maternal nutrition has profound and lasting effects on growth and health from infancy into adulthood. The aim of this manuscript was to assess diet quality and nutrient adequacy in preconception and pregnancy in BABY1000 pilot study participants (n = 171). Study design and methods: The Australian Eating Survey (AES) Food Frequency Questionnaire was administered to women based in Sydney, Australia, at preconception or 12 weeks' gestation (n = 158), and again at 36 weeks' gestation (n = 99). Primary outcomes were diet quality and nutrient intake. Diet quality was evaluated using the AES diet quality subscale, the Australian Recommended Food Score (ARFS). Nutrient intakes were compared to Australian Nutrient Reference Values. Diet quality and nutrient intakes were not consistent with Australian recommendations. Over 83% of women exceeded the suggested target limits for percentage energy from saturated fat. Median ARFS was 37 at baseline, and 38 in late pregnancy (maximum score 73). Inadequate micronutrient intakes from food were common; no participants met the Estimated Average Requirement for iron, 76%–84% for iodine, 70%–78% for calcium and 44%–50% for folate. Maternal diet quality and nutrient intakes in the current sample are inconsistent with pregnancy recommendations and therefore may not be supporting optimal perinatal or long‐term offspring health. Stronger messaging around the importance of prenatal nutrition, prevalence of dietary inadequacy, and availability of reliable support and information specific to nutrition in pregnancy is crucial in supporting women to improve their nutrition both before and during pregnancy.
Clinical and epidemiological profile of ST‐segment elevation myocardial infarction patients in a megacity of west of Iran
Authors: Janjani Parisa , Motevaseli Sayeh , Salimi Yahya , Bavandpouri Sousan Mahmoudi , Ziapour Arash , Salehi Nahid , Karami Sahar 
Published: May 2023

AbstractBackground and AimsLow‐ and middle‐income nations account for at least three‐quarters of cardiovascular disease deaths worldwide. This study aimed to obtain real knowledge about ST segment elevation myocardial infarction (STEMI) patients and provide the context for developing a principles for care quality improvement.MethodThis cross‐sectional study was conducted from July 2018 through December 2019. The study sample consisted of1169 eligible patients based on inclusion criteria. The data were collected using the standard EROP and three specialized, trained questionnaires. The collected data were checked by the quality control officer and analyzed using Stata Version 14.ResultsPatient baseline characteristics showed that body mass index, low‐density lipoprotein, high‐density lipoprotein, total cholesterol, and triglyceride levels were higher in women. Also, females recorded a considerable history of diabetes mellitus, hypertension, and hypercholesterolemia compared to men. The results also showed that most men were smokers (46.80%). Aspirin (94.27%), statins (91.48%), and clopidogrel (90.68%) were the common medications used at hospital discharge for patients.ConclusionThe present study suggests that identifying and managing modifiable risk factors can improve cardiovascular disease outcomes. Also, considering the early identification of STEMI patients with new therapies can effectively decrease the rate of cardiovascular disease and its attributed health outcomes.
Barriers to HPV vaccine uptake in adolescents of the indigenous Andean community of Peru
Authors: De La Cruz‐Ramirez Yuliana Mercedes , Olaza‐Maguiña Augusto Felix 
Published: May 2023

SynopsisThere are cultural and institutional barriers to HPV vaccine uptake in Peruvian indigenous adolescents, highlighting the presence of myths and distrust towards vaccines and health personnel.
Guide to equine exotic vectorborne diseases and their risks to UK horses
Authors: Whitlock Fleur , Colgate Victoria , Newton Richard 
Published: May 2023

Background: Infectious diseases remain a constant threat to human and animal populations, with the potential for far‐reaching and diverse impacts on health, welfare, trade, livelihoods and the economy. Over recent years, many infectious diseases have increased in incidence and geographical range and this is the result of a multitude of factors, of which population expansion, globalisation and climate change are notable. With increased international connectivity, emergence and re‐emergence of exotic diseases have arisen on multiple occasions in the UK.Aim of the article: This article reviews the epidemiology, clinical presentation, diagnosis, control and prevention of the key equine vectorborne diseases. It also outlines the surveillance initiatives in place for detection of these diseases, and the current risk status they pose to the UK equine population.
Uncertainty in phosphorus fluxes and budgets across the US long‐term agroecosystem research network
Authors: Welikhe Pauline , Williams Mark R. , King Kevin , Bos Janae , Akland Mark , Baffaut Claire , Beck E. Glynn , Bierer Andrew , Bosch David D. , Brooks Erin S. , Buda Anthony R. , Cavigelli Michel , Faulkner Joshua , Feyereisen Gary W. , Fortuna Ann‐Marie , Gamble Joshua. , Hanrahan Brittany R. , Hussain Mir Zaman , Kovar John L. , Lee Brad , Leytem April B. , Liebig Mark A. , Line Daniel , Macrae Merrin L. , Moorman Thomas B. , Moriasi Daniel , Mumbi Rose , Nelson Nathan , Ortega‐Pieck Aline , Osmond Deanna , Penn Chad , Pisani Oliva , Reba Michele L. , Smith Douglas R. , Unrine Jason , Webb Pearl , White Kate E. , Wilson Henry , Witthaus Lindsey M. 
Published: May 2023

AbstractPhosphorus (P) budgets can be useful tools for understanding nutrient cycling and quantifying the effectiveness of nutrient management planning and policies; however, uncertainties in agricultural nutrient budgets are not often quantitatively assessed. The objective of this study was to evaluate uncertainty in P fluxes (fertilizer/manure application, atmospheric deposition, irrigation, crop removal, surface runoff, and leachate) and the propagation of these uncertainties to annual P budgets. Data from 56 cropping systems in the P‐FLUX database, which spans diverse rotations and landscapes across the United States and Canada, were evaluated. Results showed that across cropping systems, average annual P budget was 22.4 kg P ha−1 (range = −32.7 to 340.6 kg P ha−1), with an average uncertainty of 13.1 kg P ha−1 (range = 1.0–87.1 kg P ha−1). Fertilizer/manure application and crop removal were the largest P fluxes across cropping systems and, as a result, accounted for the largest fraction of uncertainty in annual budgets (61% and 37%, respectively). Remaining fluxes individually accounted for <2% of the budget uncertainty. Uncertainties were large enough that determining whether P was increasing, decreasing, or not changing was inconclusive in 39% of the budgets evaluated. Findings indicate that more careful and/or direct measurements of inputs, outputs, and stocks are needed. Recommendations for minimizing uncertainty in P budgets based on the results of the study were developed. Quantifying, communicating, and constraining uncertainty in budgets among production systems and multiple geographies is critical for engaging stakeholders, developing local and national strategies for P reduction, and informing policy.
Synthesis of Chromeno[2,3‐b]quinoline derivatives via ZnCl2‐Mediated three‐component reaction of 2‐Aminochromenones, benzaldehydes and Cyclohexane‐1,3‐dione
Authors: Gan Jianbo , Zhou Wenyan , Shen Xinliang , Wang Cunde 
Published: May 2023

AbstractA novel ZnCl2‐promoted three‐component reaction strategy for the synthesis of hexahydrochromeno[2,3‐b]quinoline derivatives via the Aldol condensation/Michael addition/cycloaddition/dehydration cascade reaction of 2‐amino‐4H‐chromen‐4‐ones, aromatic aldehydes, and cyclohexane‐1,3‐dione was investigated. This procedure is environmentally friendly, highly efficient, and has a broad scope. The structures of the products obtained were determined based on x‐ray diffraction studies.
Opportunities to improve diagnosis in emergency transfers to the pediatric intensive care unit
Authors: Mehta Sanjiv D. , Congdon Morgan , Phillips Charles A. , Galligan Meghan , Hanna Christina M. , Muthu Naveen , Ruiz Jenny , Stinson Hannah , Shaw Kathy , Sutton Robert M. , Rasooly Irit R. 
Published: May 2023

AbstractBackgroundLate recognition of in‐hospital deterioration is a source of preventable harm. Emergency transfers (ET), when hospitalized patients require intensive care unit (ICU) interventions within 1 h of ICU transfer, are a proximal measure of late recognition associated with increased mortality and length of stay (LOS).ObjectiveTo apply diagnostic process improvement frameworks to identify missed opportunities for improvement in diagnosis (MOID) in ETs and evaluate their association with outcomes.Design, Settings, and ParticipantsA single‐center retrospective cohort study of ETs, January 2015 to June 2019. ET criteria include intubation, vasopressor initiation, or 60 mL/kg fluid resuscitation 1 h before to 1 h after ICU transfer. The primary exposure was the presence of MOID, determined using SaferDx. Cases were screened by an ICU and non‐ICU physician. Final determinations were made by an interdisciplinary group. Diagnostic process improvement opportunities were identified.Main Outcome and MeasuresPrimary outcomes were in‐hospital mortality and posttransfer LOS, analyzed by multivariable regression adjusting for age, service, deterioration category, and pretransfer LOS.ResultsMOID was identified in 37 of 129 ETs (29%, 95% confidence interval [CI] 21%–37%). Cases with MOID differed in originating service, but not demographically. Recognizing the urgency of an identified condition was the most common diagnostic process opportunity. ET cases with MOID had higher odds of mortality (odds ratio 5.5; 95% CI 1.5−20.6; p = .01) and longer posttransfer LOS (rate ratio 1.7; 95% CI 1.1–2.6; p = .02).ConclusionMOID are common in ETs and are associated with increased mortality risk and posttransfer LOS. Diagnostic improvement strategies should be leveraged to support earlier recognition of clinical deterioration.