bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal and perinatal outcome of women with early‐onset severe pre‐eclampsia before 28 weeks: Is expectant management beneficial in a low‐resource country? A prospective observational study
Authors: Gangadhar Lekha , Rengaraj Sasirekha , Thiyagalingam Sutharsika , Bethou Adhisivam 
Published: December 2022

AbstractObjectiveTo study the maternal and perinatal outcomes in women with severe pre‐eclampsia before 28 weeks of pregnancy.MethodsA descriptive study from a tertiary care center. All consecutive women with severe pre‐eclampsia withonset before 28 weeks of pregnancy were included. The details were collected in a predesigned structured proforma prospectively.ResultsThe study cohort included 145 women with a mean maternal age of 26.97 ± 5.36 years (range 19–47 years). The mean duration of prolongation of pregnancy was 13.04 ± 10.57 days (range 1–51 days). A total of 29.7% (n = 43) of women had at least one major adverse maternal outcome, and the most common was HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome (n = 24,16.6%), followed by eclampsia (n = 12,8.3%). The stillbirth rate was high (n = 103,68.7%), and most occurred in the antepartum period. Of 47 (31.3%) neonates born alive, only eight (17.02%;8/47) survived up to 28 days of life. Fetal growth restriction with Doppler abnormalities and neonatal sepsis were the most common reasons for perinatal mortality.ConclusionExpectant management should not be considered routinely when the onset of severe pre‐eclampsia is before 25+6 weeks of pregnancy. Between 26 and 27+6 weeks it can be offered under close monitoring and the perinatal survival depends on the neonatal services available in their facility.
Bioactive ZnO‐assisted 1393 glass scaffold promotes osteogenic differentiation: Some studies
Authors: Ali Akher , Paladhi Ankush , Hira Sumit Kumar , Singh Bhisham Narayan , Pyare Ram 
Published: December 2022

AbstractWe developed ZnO‐assisted 1393 bioactive glass‐based scaffold with suitable mechanical properties through foam replica technique and observed to be suitable for bone tissue engineering application. However, the developed scaffolds' ability to facilitate cellular infiltration and integration was further assessed through in vivo studies in suitable animal model. Herein, the pure 1393 bioactive glass (BG) and ZnO‐assisted 1393 bioactive glass‐ (ZnBGs; 1, 2, 4 mol% ZnO substitution for SiO2 in pure BG is named as Z1BG, Z2BG, Z3BG, respectively) based scaffolds were prepared through sol–gel route, followed by foam replica techniques and characterized by a series of in vitro and some in vivo tests. Different cell lines like normal mouse embryonic cells (NIH/3T3), mouse bone marrow stromal cells (mBMSc), peripheral blood mononuclear cells, that is, lymphocytes and monocytes (PBMC) and U2OS (carcinogenic human osteosarcoma cells) were used in determination and comparative analysis of the biological compatibility of the BG and ZnBGs. Also, the alkaline phosphatase (ALP) activity, and osteogenic gene expression by primer‐specific osteopontin (OPN), osteocalcin (OCN), and glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) genes were performed to study osteogenic differentiability of the stromal cells in different BGs. Moreover, radiological and histopathological tests were performed in bone defect model of Wister rats to evaluate the in vivo bone regeneration and healing. Interestingly, these studies demonstrate augmented biological compatibility, and superior osteogenic differentiation in ZnBGs, in particular Z3BG than the pure BG in most cases.
Design, synthesis, and in silico study of hybrid oxoazetidine conjugated thiazoles as anti‐EGFR with cytotoxicity activity
Authors: Pathak Prateek , Gupta Santosh , Grishina Maria , Khalilullah Habibullah , Verma Amita 
Published: December 2022

AbstractWe report a series of hybrid oxoazetidine conjugated thiazoles as epidermal growth factor receptor (EGFR) inhibitors, which were synthesized and tested using a variety of in silico and in vitro studies. The compounds were found to be active against breast and hepatic cancer cell lines, with Compounds 7a, 7b, and 7e being the most potent ones. The derivatives were also evaluated for molecular docking and complementarity studies to explicate fundamental substituent groups essential for their bioactivity. Moreover, the structural activity relationship of the analogues was performed for future compound optimization. These studies advocated that the analogues have a high affinity towards EGFR with favorable anticancer potential. The study advised that the derivatives have potency against breast and hepatic cancer and can assist as an initial scaffold for further development of anti‐EGFR compounds.
Development of an MRI‐Based Radiomics‐Clinical Model to Diagnose Liver Fibrosis Secondary to Pancreaticobiliary Maljunction in Children
Authors: Yang Yang , Zhang Xinxian , Zhao Lian , Mao Huimin , Cai Tian‐na , Guo Wan‐liang 
Published: December 2022

BackgroundPreoperative diagnosis of liver fibrosis in children with pancreaticobiliary maljunction (PBM) is needed to guide clinical decision‐making and improve patient prognosis.PurposeTo develop and validate an MR‐based radiomics‐clinical nomogram for identifying liver fibrosis in children with PBM.Study TypeRetrospective.PopulationA total of 136 patients with PBM from two centers (center A: 111 patients; center B: 25 patients). Cases from center A were randomly divided into training (74 patients) and internal validation (37 patients) sets. Cases from center B were assigned to the external validation set. Liver fibrosis was determined by histopathological examination.Field Strength/SequenceA 3.0 T (two vendors)/T1‐weighted imaging and T2‐weighted imaging.AssessmentClinical factors associated with liver fibrosis were evaluated. A total of 3562 radiomics features were extracted from segmented liver parenchyma. Maximum relevance minimum redundancy and least absolute shrinkage and selection operator were recruited to screen radiomics features. Based on the selected variables, multivariate logistic regression was used to construct the clinical model, radiomics model, and combined model. The combined model was visualized as a nomogram to show the impact of the radiomics signature and key clinical factors on the individual risk of developing liver fibrosis.Statistical TestsMann–Whitney U and chi‐squared tests were used to compare clinical factors. P < 0.05 was considered statistically significant in the final models.ResultsTwo clinical factors and four radiomics features were selected as they were associated with liver fibrosis in the training (AUC, 0.723, 0.927), internal validation (AUC, 0.718, 0.885), and external validation (AUC, 0.737, 0.865) sets. The radiomics‐clinical nomogram yielded the best performance in the training (AUC, 0.977), internal validation (AUC, 0.921), and external validation (AUC, 0.878) sets, with good calibration (P > 0.05).Data ConclusionOur radiomic‐based nomogram is a noninvasive, accurate, and preoperative diagnostic tool that is able to detect liver fibrosis in PBM children.Evidence Level3.Technical EfficacyStage 2.
Weekly symptom profiles of nonhospitalized individuals infected with SARS‐CoV‐2 during the Omicron outbreak in Hong Kong: A retrospective observational study from a telemedicine center
Authors: Luo Jingyuan , Zhang Jialing , Tang Hiu To , Wong Hoi Ki , Ma Yanfang , Xie Duoli , Peng Bo , Lyu Aiping , Cheung Chun Hoi , Bian Zhaoxiang 
Published: December 2022

AbstractOmicron BA.2.2 is the dominant variant in the Hong Kong outbreak since December 31, 2021. There is no study reporting the weekly symptom profile after infection. In this retrospective study, participants who tested positive for SARS‐CoV‐2 after December 31, 2021, and registered in the telemedicine system between March 14 and May 6, 2022, were analyzed. Among registered 12 950 self‐quarantined COVID‐19‐positive patients, 11 776 symptomatic patients were included for weekly symptom profile analysis. A total of 4718 (40.1%) patients reported symptoms in the first week after a positive test, 2501 (21.2%) in the second week, 1498 (12.7%) in the third week, 1048 (8.9%) in the fourth week, and 2011 (17.1%) in over 4 weeks. Cough was the most common symptom in all participants. Patients in the first week had higher odds of reporting fever (0.206, 95% confidence interval [CI]: 0.161–0.263, p < 0.001) and sore throat (0.228, 95% CI: 0.208–0.252, p < 0.001). Patients in over 4 weeks had higher odds of reporting fatigue (1.263, 95% CI: 1.139–1.402, p < 0.001). Further, having at least two vaccine doses linked to lower odds of having fever (0.675, 95% CI: 0.562–0.811, p < 0.001), but not associated with the presence of cough and fatigue. Diabetic patients had higher odds of reporting diarrhea (1.637, 95% CI: 1.351–1.982, p < 0.001). Symptoms from Omicron infection may last for more than 4 weeks and symptom profiles vary from week to week. Vaccination and comorbidity affect the symptom profiles.
Disparities in survival outcomes among Black patients with HPV‐associated oropharyngeal cancer
Authors: Baliga Sujith , Mitchell Darrion , Yildiz Vedat O. , Gogineni Emile , Konieczkowski David J. , Grecula John , Blakaj Dukagjin M. , Liu Xuefeng , Gamez Mauricio E. 
Published: December 2022

AbstractPatients with human papillomavirus‐associated oropharyngeal squamous cell carcinoma (HPV‐OPSCC) have a favorable prognosis and excellent overall survival (OS), and studies have demonstrated these findings in cohorts of predominantly White patients. Racial/ethnic (R/E) minorities, particularly Black patients, with head and neck squamous cell carcinoma (HNSCC) have worse survival outcomes compared with White patients. In this study, we aimed to determine if Black patients with HPV‐OPSCC have a similar favorable prognosis to the White population. This was a population‐based retrospective cohort study that analyzed HNSCC patients using the National Cancer Database from 2010 to 2016. We identified patients with Stage I–IV HPV‐ OPSCC who were treated with radiation, surgery, chemotherapy, or a combination of modalities. Patient outcomes were stratified by R/E groups including White Versus Black patients. The main outcome in this study was OS. Analyses for proportions of categorical variables were performed using a χ2 or Fisher's exact test. Univariate and multivariate time‐to‐event survival analyses were performed using Kaplan–Meier product limit estimates and log‐rank test to test the differences between strata. A Cox proportional hazards regression model was used to assess the association between covariates and risk of death (OS). We identified 9256 OPSCC patients who met inclusion criteria and were treated between 2010 and 2016, of which 7912 were White (85.5%) and 1344 were Black (14.5%). A total of 1727 were HPV‐OPSCC, of which 1598 were White (92.5%) and 129 (7.5%) were Black. By race, the 5‐year OS for White versus Black OPSCC patients was 42% versus 23%, respectively (log‐rank, p < 0.0001). Among HPV‐positive OPSCC patients, the 5‐year OS for White versus Black patients was 65% versus 39% (log‐rank, p < 0.0001). Among HPV‐negative patients, the 5‐year OS for White versus Black patients was 36% versus 13% (log‐rank, p < 0.0001). On multivariate analysis, after accounting for age, sex, insurance status, income, Charlson–Deyo score, receipt of surgery, distance from facility, and total treatment time, Black race trended toward, but was not associated with worse survival. Hazard ratio (HR:1.24, 95% confidence interval [CI] 0.85–1.81, p = 0.255). This national cohort study of OPSCC patients demonstrates that Black patients with HPV‐OPSCC have a poor prognosis and OS similar to HPV‐negative White patients. This may be partly due to socioeconomic barriers such as insurance and income. Further work is needed to better understand the specific drivers of inferior survival outcomes in this specific patient population.
Physical compatibility of medications with concentrated neonatal and pediatric parenteral nutrition: A simulated Y‐site drug compatibility study
Authors: Ross Emma L. , Petty Kirsten , Salinas Allison , Her Cheng , Carpenter John F. 
Published: December 2022

AbstractBackgroundThe physical intravenous Y‐site compatibility of 15 different medications with highly concentrated neonatal and pediatric parenteral nutrition (PN) compounds is described, using existing and novel methods.MethodsPN formulations were developed based on common prescribing practices in a 400+‐bed freestanding children's hospital. Medications at commonly used pediatric concentrations were mixed in a 1:1 ratio with both pediatric and neonatal PN formulations and incubated at room temperature for 4 h to simulate Y‐site administration. Samples were then analyzed using the light obscuration (LO) technique, as recommended by United States Pharmacopeia (USP) chapter <788>, in addition to novel flow imaging (FI) microscopy and backgrounded membrane imaging (BMI). Physical compatibility was determined using USP <788> particle count limits for all techniques.ResultsMost combinations were found to be compatible per USP <788> thresholds. Pediatric PN was incompatible by at least two methods with cisatracurium 2 mg/ml, sildenafil 0.8 mg/ml, furosemide 10 mg/ml, and ketamine 10 mg/ml. Neonatal PN was incompatible by at least two methods with cisatracurium 2 mg/ml and furosemide 10 mg/ml. Overall, results for 20 of the 30 combinations (66%) agreed across all three methods. FI and BMI results agreed for 22 of 30 combinations. LO agreed with FI in 25 of 30 combinations, and BMI and LO results agreed in 23 of 30 combinations.ConclusionMost combinations tested were found to be compatible across all methods. Novel methods of FI and BMI seem useful to further evaluate LO findings and improve accuracy of particle counts when assessing PN‐medication combinations.
High‐performance liquid chromatography micro‐fraction bioactive evaluation combined with countercurrent chromatographic separation of antioxidants from Citrus peel and their tyrosinase inhibition activities
Authors: Fang Liqun , Lin Tingting , Chen Ben , You Haibo , Wu Chunyan , Chu Chu , Tong Shengqiang 
Published: December 2022

In the present study, high‐performance liquid chromatography micro‐fraction bioactive evaluation and high speed countercurrent chromatography were performed on screening, identification and isolation of antioxidants from Citrus peel. Three compounds were screened as antioxidants and tyrosinase inhibitors using 2,2′‐azino‐bis (3‐ethyl‐benzothiazoline‐6‐sulfonic acid) radical cation scavenging assay and tyrosinase activity test, then they were identified as eriocitrin, narirutin and hesperidin. Moreover, the solvent system ethyl acetate‐n‐butanol‐water (6:4:10, v/v/v) was used for separation of ethyl acetate extract of Citrus peel by high speed countercurrent chromatography. In total, 0.45 mg of eriocitrin with 87.10% purity, 2.04 mg of narirutin with 95.19% purity and 1.35 mg of hesperidin with 95.19% purity were obtained from 20 mg of ethyl acetate extract of Citrus peel in a single run and then each component was subjected to 2,2′‐azino‐bis (3‐ethyl‐benzothiazoline‐6‐sulfonic acid) radical cation scavenging assay and tyrosinase inhibition assay. Eriocitrin showed great antioxidant activity (the half‐maximum concentration: 3.65 µM) and tyrosinase inhibition activity (the half‐maximum concentration: 115.67 µM), while narirutin and hesperidin exhibited moderate activity. Tyrosinase inhibition activity for eriocitrin in vitro was reported for the first time. Furthermore, molecular docking between eriocitrin and mushroom tyrosinase was also studied.
Phosphorus adsorption in a degraded soil under forestry recovery after bauxite mining in Paragominas, eastern Amazon, Brazil
Authors: dos Santos Cassio Rafael Costa , Kato Osvaldo Ryohei , Noronha Norberto Cornejo , do Socorro Freitas Souza Luana , de Oliveira Ferreira Eric Victor , de Matos Gilson Sérgio Bastos , de Araújo Dênmora Gomes , Gama Marcos André Piedade 
Published: December 2022

AbstractThe availability and retention of phosphorus (P) in soils under recovery process after mining operations play an important role in the management of this nutrient. The objective of this study was to evaluate the P adsorption in a reconstituted soil as a function of two forest recovery processes after bauxite mining. We evaluated three systems: native forest (FOR), planting of forest seedlings after bauxite mining (TPL), and natural regeneration of vegetation after bauxite mining (NRV). In each system, eight sampling plots were deployed. In each plot, we collected litter and soil samples. The soil samples were collected at depths of 0–5, 5–10, 10–20, and 20–40 cm, for soil chemical analysis and adjustment of P adsorption isotherms. We also performed an inventory of the tree vegetation to obtain basal area (G) and species diversity (H′). Forest was significantly superior with respect to most soil fertility, litter, and vegetation attributes, followed by natural regeneration and planting. In general, the adsorption curves and maximum phosphorus adsorption capacity (MPAC) in soil followed the order planting > natural regeneration > forest. We observed a negative relationship between phosphorus adsorption and soil organic matter, potential acidity, and available phosphorus. This result highlights the importance of biomass conservation and maintenance to ensure phosphorus availability in reclamation practices. Furthermore, such results indicate that both soil cover and plant species diversity should be considered when selecting species to improve P availability for reclamation of mined areas.
Interactive effects of nutrients and temperature on herbivorous predation in a coastal plankton community
Authors: Franzè Gayantonia , Anderson Stephanie I. , Kling Joshua D. , Wilburn Paul , Hutchins David A. , Litchman Elena , Rynearson Tatiana A. , Menden‐Deuer Susanne 
Published: December 2022

AbstractMarine microbial communities in coastal environments are subject to both seasonal fluctuations and anthropogenic alterations of environmental conditions. The separate influences of temperature and resource‐dependency on phytoplankton growth, community, and ecosystem metabolism are relatively well understood. However, winners and losers in the ocean are determined based on the interplay among often rapidly changing biological, chemical and physical drivers. The direct, indirect, and interactive effects of these conditions on planktonic food web structure and function are poorly constrained. Here, we investigated how simultaneous manipulation of temperature and nutrient availability affects trophic transfer from phytoplankton to herbivorous protists, and their resulting implications at the ecosystem level. Temperature directly affected herbivorous protist composition; ciliates dominated (66%) in colder treatment and dinoflagellates (60%) at warmer temperatures. Throughout the experiments, grazing rates were < 0.1 d−1, with higher rates at subzero temperatures. Overall, the nutrient–temperature interplay affected trophic transfer rates antagonistically when nutrients were amended, and synergistically, when nutrients were not added. This interaction resulted in higher percentages of primary production consumed under nutrient unamended compared to nutrient amended conditions. At the ecosystem level, these changes may determine the fate of primary production, with most of the production likely exported out of the pelagic zone in high‐temperature and nutrient conditions, while high‐temperature and low‐nutrient availability strengthened food web coupling and enhanced trophic transfer. These results imply that in warming oceans, management of coastal nutrient loading will be a critical determinant of the degree of primary production removal by microzooplankton and dependent ecosystem production.
Alternating [1.1.1]Propellane‐(Meth)Acrylate Copolymers: A New Class of Dielectrics with High Energy Density for Film Capacitors
Authors: Cheng Xiang‐Yue , Feng Qi‐Kun , Dang Zhi‐Min , Du Fu‐Sheng , Li Zi‐Chen 
Published: December 2022

AbstractPolymer dielectrics with high energy density are of urgent demand in electric and electronic devices, but the tradeoff between dielectric constant and breakdown strength is still unsolved. Herein, the synthesis and molar mass control of three alternating [1.1.1]propellane‐(meth)acrylate copolymers, denoted as P‐MA, P‐MMA, and P‐EA, respectively, are reported. These copolymers exhibit high thermal stability and are semi‐crystalline with varied glass transition temperatures and melting temperatures. The rigid bicyclo[1.1.1]pentane units in the polymer backbone promote the orientational polarization of the polar ester groups, thus enhancing the dielectric constants of these polymers, which are 4.50 for P‐EA, 4.55 for P‐MA, and 5.11 for P‐MMA at 10 Hz and room temperature, respectively. Moreover, the high breakdown strength is ensured by the non‐conjugated nature of bicyclo[1.1.1]pentane unit. As a result, these copolymers show extraordinary energy storage performance; P‐MA exhibits a discharge energy density of 9.73 J cm–3 at 750 MV m–1 and ambient temperature. This work provides a new type of promising candidates as polymer dielectrics for film capacitors, and offers an efficient strategy to improve the dielectric and energy storage properties by introducing rigid non‐conjugated bicyclo[1.1.1]pentane unit into the polymer backbone.
Verification of the shaped beam feed for high aperture usage efficiency single offset parabolic reflector compact antenna test range
Authors: Zhang Liang , Yao Yuan , Chen Tianyang , Li Zhi , Ruan Jinbo , Yu Junsheng , Chen Xiaodong 
Published: December 2022

AbstractIn this letter, to verify that the shaped beam feed can enhance the aperture usage efficiency of a single‐offset parabolic reflector compact antenna test range (CATR), a shaped beam horn is proposed. First, we obtain the radiation intensity function of the feed. Then, a coaxial cavity horn feed with a half‐ring is designed to shape the illumination that reaches the main reflector. Measured results demonstrate that, with no edge treatment, the quiet zone size can be up to 75% of the main reflector diameter under 1.20 dB amplitude variations and 12° phase variations at 102.40 GHz, and 70% aperture usage efficiency ranging from 102 to 103 GHz with phase variations less than 12° and amplitude variations less than 1.40 dB. The design verifies that the shaped beam feed can enhance the aperture usage efficiency of a single‐offset CATR.