bluuebunny/crossref_metadata_2025_split huggingface dataset:
ELISPOT assays with pp65 peptides or whole HCMV antigen are reliable predictors of immune control of HCMV infection in seropositive kidney transplant recipients
Authors: Zavaglio Federica , Rivela Francesca , Cassaniti Irene , Arena Francesca , Gabanti Elisa , Asti Anna L. , Lilleri Daniele , Rampino Teresa , Baldanti Fausto , Gregorini Marilena 
Published: January 2023

AbstractHuman cytomegalovirus (HCMV) infection represents a major complication for solid organ transplant recipients. The aim of this study was to verify if the measurement of HCMV‐specific T‐cells could help to identify patients protected against HCMV disease cytokine flow cytometry using infected dendritic cells as stimulus (CFC‐iDC, which discriminates between CD4+ and CD8+ T cells), and ELISPOT, using infected cell lysate (ELISPOT‐iCL) or pp65 (ELISPOT‐pp65) as stimulus, were adopted. Among the 47 kidney transplant recipients (KTR) enrolled, 29 had a self‐resolving HCMV infection (Controllers) and 18 required antiviral treatment (Non‐Controllers). HCMV‐specific T‐cell frequency at the peak of HCMV infection identified Controllers and Non‐Controllers, although the diagnostic performance of CD8+ CFC‐iDC (area under the curve [AUC] of the receiver‐operator characteristic curve: 0.65) was lower than that of CD4+ CFC‐iDC (AUC: 0.83), ELISPOT‐iCL (AUC: 0.83) and ELISPOT‐pp65 (AUC: 0.80). CFC‐iDC detected a protective immune reconstitution significantly earlier (median time: 38 days) than ELISPOT‐iCL and ELISPOT‐pp65 (median time: 126 and 133 days, respectively). Time to protective immune reconstitution in Non‐Controllers was significantly longer than in Controllers with the ELISPOT and the CD4+ CFC‐iDC assays, but not with CD8+ CFC‐iDC. The majority of patients did not require antiviral treatment after protective immune reconstitution, with the exception of five patients according to CFC‐iDC assay, one patient according to ELISPOT‐iCL assay and three patients according to ELISPOT‐pp65 assay. Monitoring the HCMV‐specific immunological reconstitution with is effective in discriminating KTR at risk of or protected from HCMV disease and the ELISPOT assays are suitable for implementation in the clinical setting.
It is time to improve the acceptance of COVID‐19 vaccines among people with chronic diseases: A systematic review and meta‐analysis
Authors: Zhao Yang , Du Juan , Li Zhen , Xu Zhe , Wu Yaxin , Duan Wenshan , Wang Wenjing , Zhang Tong , Xu Junjie , Wu Hao , Huang Xiaojie 
Published: January 2023

AbstractThis study aims to investigated COVID‐19 vaccine acceptance among people with chronic diseases and the factors correlating with their vaccination hesitancy. The articles were searched in PubMed, Ovid, EMBASE, and web of science databases between December 2019 and October 2022. Cross‐sectional studies, including the acceptance of the COVID‐19 vaccine by patients with chronic diseases (≥18 years old), were included in this study. The outcomes included the proportion and 95% confidence interval (95% CI) of chronic disease patients willing to be vaccinated and the odds ratio (OR) and 95% CI of correlating factors. The source of heterogeneity was analyzed through meta‐regression and subgroup analysis. We included 31 studies involving 57 875 patients with chronic disease. The overall COVID‐19 vaccine acceptance among patients with chronic disease was 0.65 (95% CI, 0.59–0.72). The acceptance among the elderly patients was 0.53 (95% CI, 0.26–0.80). South America had the highest COVID‐19 vaccine acceptance rate and Asia the lowest, while on a country level, the United Kingdom had the highest acceptance rate among patients with chronic diseases. People with rheumatic immune diseases had the lowest rate of COVID‐19 vaccine acceptance. Concerns about vaccine safety had a statistically different effect on acceptance. Overall, the health systems ought to focus on educating specific groups of individuals on the benefits of COVID‐19 vaccination and addressing safety concerns.
The bright side of trust‐less relationships: A dyadic investigation of the role of trust congruence on supplier knowledge acquisition across borders
Authors: Wang Lei , Zhang Chun , Narayanan Sriram 
Published: January 2023

AbstractTrust is considered essential to interfirm knowledge acquisition across borders. However, recent studies indicate that interfirm collaboration can thrive even in low trust situations. This study proposes that low trust can facilitate supplier knowledge acquisition (SKA) across borders if it is aligned with the other party's trust. Rather than high trust from a single party, trust congruence—similar levels of trust from buyers and suppliers regardless of their levels—may be more predictive of successful knowledge acquisition across borders. We further propose that different types of trust congruence have distinct effects on SKA across borders. Last, we propose that the influence of trust congruence on SKA is conditional on the presence of effective knowledge appropriability mechanisms (KAMs) and institutional distance between buyer and supplier home countries in cross‐border transactions. Data are collected from 648 managers working for 162 matched dyads of manufacturing suppliers in China and buyers from 24 OECD countries. The findings support the propositions and suggest that supply chain managers should pay attention to aligning trust levels with their partners in cross‐border transactions, and especially do so when lacking effective KAMs and when buyers and suppliers are from similar institutional environments.
Zinc concentration and bioavailability of Chinese steamed bread prepared from foliar zinc‐biofortified wheat grain
Authors: Wang Shaoxia , Shi Cailing , Tian Xiaohong , Liu Qing 
Published: January 2023

AbstractBACKGROUNDIncreasing the concentration of zinc (Zn) in a widely consumed staple food, such as Chinese steamed bread (CSB), is a promising strategy for alleviating Zn malnutrition in humans. The aim of this study, which was based on a 2‐year field experiment, was to evaluate the effectiveness of spraying Zn fertilizer combined with commonly applied (i) pesticides and/or (ii) KH2PO4 (PK) to increase the concentration of Zn and its bioavailability in wheat grain and the CSB derived from it.RESULTSAll the foliar Zn applications (foliar Zn alone or combined with pesticides and PK) significantly increased the concentration of Zn in grain and derived CSB by 69.1% and 63.1%, respectively. Milling caused an 86–88% loss of Zn, while the process of producing CSB caused an 11–26% increase in the concentration of Zn. A net gain of 2.5–8.3 mg Zn kg−1 of CSB was achieved owing to foliar applications of Zn. The concentration of phytic acid (PA) decreased dramatically during milling (89–90%) and the production of CSB (69–72%). As a result, the Zn bioavailability was greater in the CSB than in grain. Foliar applications of Zn also increased the estimated Zn bioavailability of CSB to be as high as 5.5–7.8 mg, which is adequate for human nutrition. Enrichment with Zn had no adverse effects on the quality of CSB.CONCLUSIONThe mixture of foliar Zn with pesticides and PK represents a useful approach to improve the bioavailable Zn of CSB without altering its quality. © 2023 Society of Chemical Industry.
RNA sequencing and bioinformatics analysis of circular RNAs in asphyxial newborns with acute kidney injury
Authors: Pan Jing‐Jing , Yang Yang , Chen Xiao‐Qing , Shi Jia , Wang Mu‐Zi , Tong Mei‐Ling , Zhou Xiao‐Guang 
Published: January 2023

AbstractAs one kind of novel noncoding RNA, circular RNAs (circRNAs) are involved in different biological processes. Although growing evidences have supported the important role of circRNAs in renal diseases, the mechanism remains unclear in neonatal acute kidney injury (AKI). High‐throughput sequencing analysis was used to investigate the expression of circRNAs between hypoxia‐induced AKI neonates and controls. Bioinformatics analysis was conducted to predict the function of differentially expressed circRNAs. Finally, the differentially expressed circRNAs were screened and determined by quantitative real‐time PCR (qPCR). (1) A total of 296 differentially expressed circRNAs were identified (Fold change >2 and p < 0.05). Of them, 184 circRNAs were markedly upregulated, and 112 were significantly downregulated in the AKI group. (2) The pathway analysis showed that ubiquitin‐mediated proteolysis, renal cell carcinoma, Jak‐STAT, and HIF‐1 signaling pathways participated in AKI. (3) Top five upregulated and five downregulated circRNAs with higher fold changes were selected for qPCR validation. Hsa_circ_0008898 (Fold Change = 5.48, p = 0.0376) and hsa_circ_0005519 (Fold Change = 4.65, p = 0.0071) were significantly upregulated, while hsa_circ_0132279 (Fold Change = −4.47, p = 0.0008), hsa_circ_0112327 (Fold Change = −4.26, p = 0.0048), and hsa_circ_0017647 (Fold Change = −4.15, p = 0.0313) were significantly downregulated in asphyxia‐induced AKI group compared with the control group. This study could contribute to future research on neonatal AKI and facilitate the identification of novel therapeutic targets.
Biophysical interactions control the progression of harmful algal blooms in Chesapeake Bay: A novel Lagrangian particle tracking model with mixotrophic growth and vertical migration
Authors: Xiong Jilian , Shen Jian , Qin Qubin , Tomlinson Michelle C. , Zhang Yinglong J. , Cai Xun , Ye Fei , Cui Linlin , Mulholland Margaret R. 
Published: January 2023

AbstractClimate change and nutrient pollution contribute to the expanding global footprint of harmful algal blooms. To better predict their spatial distributions and disentangle biophysical controls, a novel Lagrangian particle tracking and biological (LPT‐Bio) model was developed with a high‐resolution numerical model and remote sensing. The LPT‐Bio model integrates the advantages of Lagrangian and Eulerian approaches by explicitly simulating algal bloom dynamics, algal biomass change, and diel vertical migrations along predicted trajectories. The model successfully captured the intensity and extent of the 2020 Margalefidinium polykrikoides bloom in the lower Chesapeake Bay and resolved fine‐scale structures of bloom patchiness, demonstrating a reliable prediction skill for 7–10 d. The fully coupled LPT‐Bio model initialized/calibrated by remote sensing and controlled by ambient environmental conditions appeared to be a powerful approach to predicting transport pathways, identifying bloom hotspots, resolving concentration variations at subgrid scales, and investigating responses of HABs to changing environmental conditions and human interference.
The impact of enterprise digital transformation on financial performance—Evidence from Mainland China manufacturing firms
Authors: Yonghong Li , Jie Shao , Ge Zhan , Ru Zhou 
Published: January 2023

AbstractFocusing on digital transformation of manufacturing enterprises, this paper investigates the relationship between digital transformation and financial performance of manufacturing enterprises through descriptive statistical analysis, correlation analysis, multilayer linear regression analysis, and group testing of the impact of digital transformation stages on the financial performance of enterprises, taking listed manufacturing companies that implement digital transformation as a sample. The research results show that there is a significant positive impact of digital transformation on financial performance of manufacturing enterprises; the more digitalized the information technology (IT) architecture is when enterprises undergo digital transformation, the closer to hybrid cloud platform + agile manufacturing, the higher the inventory turnover rate and total asset turnover rate of enterprises will be; in the early stage of digital transformation of enterprises, the profitability performance of enterprises will be reduced. However, as the digitalization process of enterprises deepens, the net sales margin and total asset return of enterprises will gradually increase, which may be due to the reason that the impact of enterprise digital transformation on profitability performance has a certain lag.
MRI conditional safety of mixed systems: Study of the impact of active implant medical device impedance on the radiofrequency‐induced lead heating
Authors: Fall Abdou Khadir , Guraliuc Anda Raluca , Monfret Nicolas , Setzu Romano 
Published: January 2023

PurposeThe aim of this paper is to study the impact of pulse generator small impedance variations on the overall radiofrequency (RF)‐induced heating of a cardiac rhythm management (CRM) lead in a 1.5 T MR system.MethodsAn analysis was conducted on two CRM pacing leads with different structural designs. The leads were connected to three CRM devices belonging to different technological platforms: two pacemakers and a cardiac resynchronization therapy defibrillator (CRT‐D). All pulse generators had a small (< ) RF input impedance compared to the overall system (pulse generator and lead) impedance. In addition, two Dummy load devices with an input impedance that is not negligible compared to the lead impedance were also studied. The implantable systems were studied in terms of RF deposited power at the lead electrodes, which is proportional to the RF‐induced heating.ResultsResults show that both leads behave very similarly in terms of RF deposited power for the same in‐vivo tangential E‐field excitation when mounting any of the pulse generators; reported differences are well below the combined uncertainty . On the other hand, both Dummy load devices resulted in a RF deposited power which differs from the other pulse generators by values larger than the combined uncertainty.ConclusionThe results of our experimental analysis show that different pulse generators would not change the RF‐induced heating behavior of a given lead, provided that the pulse generator impedances are small (in our study less than 5%) compared to the overall system impedance.
Health equilibrium in Korean adults with type 2 diabetes mellitus: A hybrid concept analysis
Authors: Seo Kawoun , Song Youngshin 
Published: January 2023

AbstractAimThe aim of the study was to provide a concept analysis of health equilibrium among patients with diabetes and introduced its operational definition.DesignA concept analysis was conducted using a hybrid model of Schwartz‐Barcott and Kim (Nursing research methodology: issues and implementations, Aspen, 1986).MethodsUsing consolidated criteria for reporting qualitative research guidelines, 10 participants with diabetes mellitus were interviewed. Each participant conducted at least two interviews, with each interview session lasting approximately 20–60 min at home or in a quiet place with some privacy. Data were analysed using a grounded theory approach.ResultsThe health equilibrium concept included four categories with 12 attributes: cognitive (commitment to health, willingness to make life adjustments, balanced awareness, maintaining control), social (social role performance, holding a social support system, participation in social relationships), behavioural (leading a balanced life, making efforts to maintain health, modulating overreaction diabetes) and psychological (hopefulness for a healthy life psychological stability) factors. Thus, health equilibrium was defined as a state in which remain committed to health, while maintaining a stable daily life, social relationships and psychological stability despite prejudices against the disease and self‐care experiences.ConclusionHealth equilibrium for diabetes patients was defined as maintaining cognitive, social, behavioural and psychological equilibrium as a process of willingly adjusting to life with diabetes. This can help people with diabetes improve self‐care and maintain social roles.
Aspiration Prevention Surgery: Clinical Factors Associated With Improvements in Oral Status Intake and Suction Frequency
Authors: Koyama Misaki , Ueha Rumi , Sato Taku , Goto Takao , Yamauchi Akihito , Kaneoka Asako , Suzuki Sayaka , Nito Takaharu , Yamasoba Tatsuya 
Published: January 2023

AbstractObjectiveIn recent years, the use of aspiration prevention surgery (APS) for the treatment of severe dysphagia has been on the rise. However, relevant clinical studies have included small samples, and the frequency of, and risk factors for postoperative complications have not been clarified. We investigated the clinical features of patients undergoing APS and whether oral‐intake status and suction frequency could be reduced.Study DesignA case series.SettingSingle‐institution academic center.MethodsWe retrospectively evaluated medical charts generated from 2010 to 2021. The clinical characteristics of patients undergoing APS, changes in the oral‐intake status (Functional Oral Intake Scale, FOIS), suction frequency before and after surgery, risk factors for postoperative complications, and factors contributing to improvements in postoperative oral‐intake status were retrieved.ResultsWe included the data of 100 patients (median age: 65 years, 72 men). Amyotrophic lateral sclerosis was the most common primary disease (28%), and glottis closure was the most common APS (69%). Postoperatively, 78% of patients showed improvements in the FOIS score, and suction frequency decreased in 85% of cases. Postoperative complications were observed in 10 patients (10%), wound infection in 6, and bleeding in 4; all improved. Higher preoperative FOIS scores were significantly associated with postoperative complications (p = 0.02).ConclusionAPS contributed to improving the FOIS score and helped reduce the suction frequency in most cases. APS can be performed safely with proper perioperative management, even in patients with poor preoperative general conditions and nutritional status.
A Survival Nomogram Containing Lymph Node Ratio for Hypopharyngeal Carcinoma Patients After Neck Dissection
Authors: Li Feiran , Huang Qiang , Hsueh Chiyao , Huang Huiying , Zhu Yi , Gong Hongli , Tao Lei , Zhou Liang , Zhang Ming 
Published: January 2023

AbstractObjectiveThe purpose of our study is to establish a survival nomogram based on lymph node ratio (LNR) in hypopharyngeal carcinoma.Study DesignRetrospective cohort study.SettingHypopharyngeal squamous cell carcinoma (HPSCC) is prone to regional metastasis. Emerging evidence has shown that LNR is a promising prognostic factor in HPSCC.MethodsFrom January 2004 to January 2018, 411 HPSCC patients who underwent neck dissection at our institution were retrospectively studied. The enrolled patients were divided into training and validation cohorts at a ratio of 7:3. A survival nomogram was finally built based on factors screened from multivariate analysis using the bidirectional stepwise method.ResultsLNR was superior to other nodal classifications for survival prediction and was used to establish the R classification. A nomogram was developed using R classification (p < .001), pT classification (p < .001), tumor invasive depth (p < .001), and internal jugular vein adhesion (p = .001). The C‐indexes were 0.712 and 0.703 in the training and validation dataset. The 36‐ and 60‐month AUCs were 0.767 and 0.766 in the training dataset and 0.713 and 0.757 in the validation dataset, respectively. The calibration curves showed relatively good agreement between the predicted and actual probability.ConclusionBased on the LNR, we developed a survival nomogram for HPSCC after neck dissection, which will be a practical tool to discriminate patients with different survival risks.
Climate Change and Otolaryngology–Head and Neck Surgery
Authors: Haugen Thorsen , Prichardo Priscilla , Hellums Ryan , Lindemann Logan 
Published: January 2023

AbstractThe COVID‐19 pandemic has illustrated that global events can have a profound impact on our health systems. While the pandemic is unprecedented, it does underscore the need to prepare for future global health concerns. Climate change is a looming threat with significant consequences for otolaryngologists and our patients. In this commentary, we discuss the need to assess our preparedness for climate change as well as the importance of reflecting on our responsibility to minimize our footprint.
Comparative Treatment Outcomes for Idiopathic Subglottic Stenosis: 5‐Year Update
Authors: Tierney William S. , Huang Li‐Ching , Chen Sheau‐Chiann , Berry Lynn D. , Anderson Catherine , Amin Milan R. , Benninger Michael S. , Blumin Joel H. , Bock Jonathan M. , Bryson Paul C. , Castellanos Paul F. , Clary Matthew S. , Cohen Seth M. , Crawley Brianna K. , Dailey Seth H. , Daniero James J. , de Alarcon Alessandro , Donovan Donald T. , Edell Eric S. , Ekbom Dale C. , Fink Daniel S. , Franco Ramon A. , Garrett Catherine Gaelyn , Guardiani Elizabeth A. , Hillel Alexander T. , Hoffman Henry T. , Hogikyan Norman D. , Howell Rebecca J. , Johns Michael M. , Kasperbauer Jan L. , Khosla Sid M. , Kinnard Cheryl , Kupfer Robbi A. , Langerman Alexander J. , Lentz Robert J. , Lorenz Robert R. , Lott David G. , Makani Samir S. , Maldonado Fabien , Matrka Laura , McWhorter Andrew J. , Merati Albert L. , Mori Matthew , Netterville James L. , O'Dell Karla , Ongkasuwan Julina , Postma Gregory N. , Reder Lindsay S. , Rohde Sarah L. , Richardson Brent E. , Rickman Otis B. , Rosen Clark A. , Rohlfing Matthew , Rutter Michael J. , Sandhu Guri S. , Schindler Joshua S. , Schneider Glenn Todd , Shah Rupali N. , Sikora Andrew G. , Sinard Robert J. , Smith Marshall E. , Smith Libby J. , Soliman Ahmed M. S. , Sveinsdóttir Sigríður , Veivers David , Verma Sunil P. , Weinberger Paul M. , Weissbrod Philip A. , Wootten Christopher T. , Shyr Yu , Francis David O. , Gelbard Alexander 
Published: January 2023

AbstractThe North American Airway Collaborative (NoAAC) previously published a 3‐year multi‐institutional prospective cohort study showing variation in treatment effectiveness between 3 primary surgical techniques for idiopathic subglottic stenosis (iSGS). In this report, we update these findings to include 5 years of data evaluating treatment effectiveness. Patients in the NoAAC cohort were re‐enrolled for 2 additional years and followed using the prespecified published protocol. Consistent with prior data, prospective observation of 487 iSGS patients for 5 years showed treatment effectiveness differed by modality. Cricotracheal resection maintained the lowest rate of recurrent operation (5%), followed by endoscopic resection with adjuvant medical therapy (30%) and endoscopic dilation (50%). These data support the initial observations and continue to provide value to providers and patients navigating longitudinal decision‐making.Level of evidence: 2—prospective cohort study.