bluuebunny/crossref_metadata_2025_split huggingface dataset:
Papier-stylo/écran-clavier : un match à l’issue incertaine
Authors: Doquet Claire 
Published: March 2023

Les outils d’écriture se sont diversifiés dans les dernières décennies, notamment à travers l’usage de l’ordinateur. Cet article examine les différences induites par l’usage de technologies distinctes : le papier et le stylo d’un côté, l’écran et le clavier de l’autre. La relation entre le scripteur et son écrit est abordée du point de vue des usagers – écrivains, journalistes, élèves en situation scolaire – à la lumière d’études génétiques, linguistiques et psychologiques. L’espace scriptural est également considéré, avec une description du rôle et des fonctions de la page d’écriture dans l’énonciation écrite et une caractérisation du traitement de texte comme à la fois imposant une linéarisation et affectant les unités spatiales – lignes et pages – d’une certaine labilité. Enfin, des « procédures siliscrites », propres à l’écriture sur traitement de texte, sont mises au jour et envisagées du point de de vue de l’impact de cette technologie sur l’écriture.
Le toucher Touch/to touch him
Authors: Crasson Aurèle , Lebrave Jean-Louis , Pedrazzi Jérémy , Alonso Laurent 
Published: March 2023

Le philosophe Jacques Derrida entreprend à plus de 50 ans de passer de la machine à écrire à l’ordinateur. Si MacWrite, le logiciel de traitement de texte qu’il gardera jusqu’à la fin de sa vie, ne modifie pas, selon lui, sa façon d’écrire, son usage pousse Derrida à reconsidérer la chaîne de production de ses textes au regard des contraintes imposées par le support numérique : le nommage des fichiers (différent du titre du texte), le stockage dans des dossiers, la sauvegarde des textes sur de nouveaux périphériques numériques et la gestion des copies que cela engendre, la communication des textes aux éditeurs et amis qui passe désormais davantage par une disquette que par une forme imprimée. L’usage du traitement de texte change, en revanche, pour Derrida une économie d’écriture qui s’exprime à travers les traces laissées dans ses fichiers nativement numériques. Cet article présente deux études parallèles menées dans le cadre du projet « Derrida Hexadécimal » : l’une concernant l’exploration de fichiers nativement numériques dans la perspective de leur étude génétique et une réflexion sur une nouvelle codicologie numérique, et l’autre présentant la genèse d’un corpus derridien, Le toucher, Jean-Luc Nancy, établie à partir des fichiers provenant des supports numériques du philosophe (disques durs et disquettes).
Ces machines qui (nous) écrivent
Authors: Lebrave Jean-Louis , Mahrer Rudolf 
Published: March 2023

Comment l’instrument d’écriture conditionne-t-il les autres composants du complexe scriptural, à savoir le scripteur, l’écrit et le processus d’écriture lui-même ? Des différentes questions que cette analyse de la production écrite en quatre termes permet de formuler, l’article retient principalement la question génétique : celle des interactions entre le processus et les outils. Après avoir rappelé, à l’aide de textes empruntés aux auteurs latins, que les réflexions sur les instruments d’écriture et leurs propriétés sont anciennes, nous nous attacherons à faire apparaître l’ambivalence du verbe écrire, qui désigne à la fois les opérations proprement scripturales (l’inscription matérielle de la trace sur le support) et les opérations abstraites de nature textuelle qui sont leur finalité. En distinguant soigneusement ces deux plans, l’analyse des machines à écrire permet d’aborder l’écriture du point de vue de son ergonomie. On est conduit à s’interroger d’une part sur la manière dont la technologie affecte la textualisation, la qualité des textes produits et les sujets de l’écriture, et d’autre part, symétriquement, sur la manière dont les technologies graphiques ne cessent de s’ajuster aux aptitudes physiques et mentales des sujets qui écrivent. Nous illustrons ces effets de feedback par les cas du traitement de texte, de la dictée et de la machine à écrire au sens étroit.
Status of integrin subunit alpha 4 promoter DNA methylation in colorectal cancer and other malignant tumors: a systematic review and meta-analysis
Authors: Jafarpour Sima , Yazdi Maryam , Nedaeinia Reza , Vatandoost Nasimeh , Ferns Gordon A. , Salehi Rasoul 
Published: March 2023

Background and purpose:
Although many recent studies have analyzed the validation of integrin subunit alpha 4 (ITGA4) biomarker for cancer detection in patients with various malignancies, the diagnostic value of ITGA4 methylation for malignant tumors remains uncertain. We performed a systematic review and meta-analysis to unravel the relationship between ITGA4 promoter methylation status and malignant tumors.

Experimental approach:
A meta-analysis was performed using the metaphor package in R 3.5 and Meta-Disc 1.4 software. Data were derived from a search of main electronic databases up to January 2022. SROC analysis was used to evaluate the status of ITGA4 promoter methylation in colorectal cancer (CRC) and other cancers. A total of 1232 tumor samples and 649 non-tumor samples from 13 studies were analyzed.

Findings/Results:
The pooled results including all types of cancer provided evidence that ITGA4 hypermethylation was more frequent in tumor samples than non-tumor samples (OR 13.32, 95% CI 7.96-22.29). Methylation of ITGA4 has a pooled sensitivity of 0.95 (95% CI: 0.94-0.97), a pooled specificity of 0.57 (95% CI: 0.54-0.60), and an area under the curve (AUC) of 0.94. When the analysis was performed independently for CRC, it revealed a higher association (OR = 20.77, 95% CI: 9.15-47.15). The assessment of ITGA4 methylation of tissue samples resulted in a pooled sensitivity of 0.99 (95% CI: 0.97-1.00) and a pooled specificity of 0.90 (95% CI: 0.86-0.93), and AUC of 0.94 for the diagnosis of CRC.

Conclusion and implications:

ITGA4 methylation analysis is a reliable method for CRC screening in tissue samples.
Betaine attenuates oxidative stress and cognitive dysfunction in an amyloid β-induced rat model of Alzheimer’s disease
Authors: Alipourfard Fatemeh , Shajiee Hooman , Nazari-Serenjeh Farzaneh , Hojati Vida , Alirezaie Masoud 
Published: March 2023

Background and purpose:
Increasing evidence indicates that oxidative stress is an important factor in the pathogenesis and progression of Alzheimer’s disease (AD). Betaine is trimethylglycine with antioxidant and neuroprotective properties. The present study aimed to evaluate the possible beneficial effects of betaine on oxidative stress and memory deficits induced by intrahippocampal injection of amyloid beta (Aß) in an AD model.

Experimental approach:
Forty adult male Wistar rats were divided into 5 equal groups: the control and Aß groups which received oral gavage of saline (1 mL daily) for 14 days. The other 3 groups (betaine + Aß) received betaine (5, 10, and 15 mg/kg, orally) for 14 consecutive days. On the 15th day, all of the groups were injected bilaterallyintrahippocampal of Aß (5 µg/µL), except controls that were injected with normal saline as a vehicle. Seven days after the Aß injection, memory was assessed in a passive avoidance test. Changes in catalase activities and glutathione peroxidase, glutathione, and malondialdehyde concentrations were investigated to determine the antioxidant activity in the rat hippocampus.

Findings/Results:
Data showed that betaine pretreatment of Aß-injected rats improved memory in avoidance tasks. In addition, betaine pretreatment attenuated oxidative stress.

Conclusion and implications:
The current findings showed that oral administration of betaine could prevent Aß-induced impairment of memory possibly through suppression of oxidative stress in the hippocampus area of rats.
Protective effect of yacon leaves extract (Smallanthus sonchifolius (Poepp.) H. Rob) through antifibrosis, anti-inflammatory, and antioxidant mechanisms toward diabetic nephropathy
Authors: Widowati Wahyu , Tjokropranoto Rita , Onggowidjaja Philips , Widya Kusuma Hanna Sari , Wijayanti Cahyaning Riski , Marthania Meganita , Yati Afif , Rizal Rizal 
Published: March 2023

Background and purpose:
Diabetic nephropathy (DN) is a chronic kidney failure, which may lead to fatality. Mesangial cell proliferation, renal inflammation, stress oxidative, and fibrosis are involved in DN progression. Yacon leaves (Smallanthus sonchifolius (Poepp.) H. Rob.) contains large amounts of phenolic compounds and it has the ability to inhibit oxidative stress, inflammation, and fibrosis. Considering the potential of yacon leaves extract (YLE), it may be used for DN treatment. This research aimed to elucidate YLE’s potential as anti-DN through anti-inflammatory, antioxidant, and antifibrosis mechanisms.

Experimental approach:
Mesangial cells were induced by glucose 20 mM for 5 days and treated with YLE concentrations as much as 5, 10, and 50 µg/mL. TGF-β1, TNF-α, and MDA levels were measured using the ELISA method. SMAD2, SMAD3, SMAD4, and SMAD7 gene expressions were analyzed using the qRT-PCR method.

Findings/Results:
YLE at 5, 10, and 50 µg/mL could reduce the levels of TGF-β1, TNF-α, and MDA compared with the DN cells model. YLE could reduce gene expressions of SMAD2, SMAD3, and SMAD4 and increase SMAD7 expression.

Conclusion and implications:
YLE potentially mitigated diabetic nephropathy through antifibrosis, anti-inflammatory, and antioxidant capacities.
MAPPING THE POTENTIAL AND DEVELOPMENT OF INDEPENDENT CATEGORY VILLAGES IN BOGOR REGENCY
Authors: Rahmi Amelia 
Published: March 2023

Independent villages are villages that have sufficient availability and access to essential services, adequate infrastructure, accessibility/transportation that is not difficult, good public services, and an already excellent administration. However, not all independent villages are able to be independent in all aspects. The ranking of village categories is based on social, economic, and social aspects. This study aims to determine the ranking of independent category village villages on different size scales and find out which villages are superior in every social, economic, and social. This study used RapidMiner to determine the ranking of independent villages and cobwebs as a mapping of the advantages of each dimension. The results of this study were obtained from 14 villages that belong to the high-independent category. From these fourteen villages, the results of mapping using cobwebs for each dimension were obtained. The mapping results show that one village excels in two dimensions, namely Bojonggede Village, in the economic and social dimensions. Meanwhile, in the ecological dimension, Sukahati Village is a superior village. Suppose you look at the advantages of each dimension, then for the first dimension, namely the economic dimension. In that case, there are five superior villages, including Tajur, Limusnunggal, Cileungsi, Pondok Udik, Bojonggede, Cibanteng, and Gunungsari Villages. The second dimension is the social dimension; one village looks superior, Bojonggede Village. Finally, in the ecological dimension, the superior village is Sukahati Village.
Meditaciones, anticipaciones y prolongaciones del diario de viaje por el Mediterráneo, de J. Marías
Authors: Gómez Álvarez Nieves 
Published: March 2023

Notas de un viaje a Oriente, el Diario del Crucero por el Mediterráneo que realizó el joven Julián Marías en 1933, durante sus años de estudio en la Facultad de Filosofía de la Universidad Central de Madrid, que constituye la reedición en tiempos recientes de su primer texto publicado, ha merecido algunas reseñas académicas. Este artículo se propone analizar, primeramente, hasta qué punto el joven Marías había ya interiorizado a sus 19 años la técnica filosófica aprendida de su maestro Ortega y Gasset, reflejada en su manera de mirar la realidad y estructurarla metafísicamente, así como en su propio estilo, animado espléndidamente por la metáfora.
Se mostrará asimismo cómo los temas principales de las Notas enlazan con los desarrollos posteriores. Hay un hilo de continuidad entre la manera de comprender la herencia helénica aquí y lo escrito en su obra Historia de la filosofía, así como lo hay entre su reflexión juvenil sobre la temporalidad con la de Antropología metafísica
Hadjadj: nuevas perspectivas en la crítica al programa transhumanista
Authors: Gutiérrez González Manuel Alejandro 
Published: March 2023

La fe en el progreso técnico ha llevado a la liberación de las energías de la naturaleza y con ello, como dice Heidegger, se ha inaugurado el peligro de “ser absorbido por la tecnología”. En esta línea se encuentra las propuestas del transhumanismo, como el biomejoramiento humano, tratando de superar las limitaciones humanas como la salud, el conocimiento, la afectividad y moral, y mortalidad haciendo uso de las nuevas tecnologías NBIC.

El filósofo francés, Fabrice Hadjadj, es un nuevo referente en la discusión del transhumanismo con sus análisis sobre la tecnología y la corporeidad humana. Mi propósito es mostrar las críticas que se encuentran en el pensamiento de Hadjadj a los núcleos esenciales del movimiento transhumanista, interpretándolas como desarrollos que continúan y profundizan las ya realizadas por autores como Jürgen Habermas y Michael Sandel; además, pretendo mostrar que son plausibles, tienen consideraciones convincentes y una nueva forma de pensar y responder al transhumanismo. La estructura está dividida en tres partes: 1) la exposición de los argumentos y crítica que Hadjadj hace a esta postura filosófica basándome en las liberaciones de nuestras limitaciones antes mencionadas; 2) centrarme en la propuesta que hace para superar esta postura, cómo complementa las críticas que hacen Habermas y Sandel desde una perspectiva metafísica; y, por último, 3) la defensa del ser humano desde su visión basada en sus “cuatro vueltas”.
OVEROVANIE VLASTNOSTÍ VLÁKNOVÝCH KOMPOZITOV NA BÁZE ORGANICKÉHO PLNIVA
Authors: Terpáková Eva 
Published: March 2023

Súčasné stavebníctvo vyžaduje produkty, ktoré vyhovujú nielen technickým požiadavkám ale zároveň spĺňajú bezpečnostné a hygienické kritéria. Z tohto dôvodu sa vyvíjajú progresívne materiály a to najmä vo forme kompozitných produktov. Pri ich výrobe sa dokáže cielene regulovať zloženie a preto aj optimalizácia výsledných vlastností. Príspevok pojednáva o testovaní paralelne vyrobených sád kompozitov s celul.zovými vláknami. Testované boli pevnostné charakteristiky, vybrané fyzikálne parametre a tepelná vodivosť. Výsledky získané z testovania kompozitov v časovom slede 28, 60 dní naznačujú perspektívnu možnosť ich aplikácie vo funkcii výplňových prvkov.
VÝBER TECHNOLÓGIE PRE SANÁCIU KONTAKTNÉHO ZATEPĽOVACIEHO SYSTÉMU
Authors: Belániová Barbora , Antošová Naďa , Kosák Martin , Vavrík Ivan 
Published: March 2023

Údržba a oprava existujúcich konštrukcií kontaktného zatepľovacieho systému je dôležitou požiadavkou v oblasti zatepľovania. Hlavnou témou je návrh sanačných metód na poškodenú konštrukciu ETICS. Ťažiskom príspevku je analýza technológií z hľadiska technickej a technologickej náročnosti, ceny a životnosti sanačného opatrenia. Cieľom je návrh a výber optimálnej sanačnej metódy v modelovom príklade.
VPLYVY ZMENY KLÍMY NA VYUŽÍVANIE HYDROENERGETICKÉ POTENCIÁLU VO VYBRANÝCH POVODIACH NA SLOVENSKU
Authors: Rončák Peter , Rumann Ján , Hlavčová Kamila , Szolgay Ján 
Published: March 2023

Článok sa zaoberá hodnotením vplyvu zmeny klímy na využívanie hydroenergetického potenciálu vo vybraných povodiach na území Slovenska. Z.kladným ukazovateľom potenciálu využitia vodnej energie je výpočet tzv. hydroenergetického potenciálu (HEP). Zmenené klimatické podmienky charakterizované najmä zmenami zrážok, potenciálnou evapotranspiráciou a teplotou vzduchu v budúcich desaťročiach boli predpovedané podľa najnovších výstupov z dvoch regionálnych modelov klimatických zmien KNMI a MPI a podľa emisného scenára A1B. Na určenie zmien dlhodobého priemerného mesačného odtoku v porovnaní medzi referenčným obdobím 1981-2010 a budúcimi časovými horizontami sme použili fyzikálne založený zrážkovo-odtokový model WetSpa. Na základe prognóz klimatických zmien podľa dvoch spom.naných scenárov výsledky naznačujú, že vplyvy zmeny klímy v budúcnosti môžu viesť k poklesu hydroenergetického potenciálu.
MONITORING STAVEB – SLEDOVÁNÍ NASAZENÍ ZVEDACÍCH PROSTŘEDKŮ
Authors: Šťastný Jiří , Motyčka Vít , Doubek Rostislav , Brandtner Michal , Bříza Lukáš 
Published: March 2023

Při realizaci pozemních staveb jsou ve velké míře využívány zvedací prostředky. Při jejich efektivním a správném využití lze lépe dodržet časový plán stavby, a tedy i termín plánovaného ukončení výstavby. Často dochází k neefektivnímu využívání zvedacích prostředků a vznikají tak prostoje nebo naopak zvedací prostředky nestíhají pokrýt požadované množství procesů. Zabýv.me se sběrem dat (časového vytížení zvedacích prostředků), které umožní posoudit využití zvedacích mechanismů v průběhu celé výstavby. Vyhodnocení naměřených dat bude podkladem pro simulační model, který umožní časovou vytíženost věžových jeřábů lépe posoudit.
KRAJINOU BRTNICKÝCH PODSTÁVKOVÝCH DOMŮ
Authors: Šulcová Stanislava 
Published: March 2023

Nadcházející článek je volným pokračováním článku „Mikulášovice a jejich zapomenuté podstávky“, který byl zveřejněn v čísle 01/2017. Článek „Krajinou brtnických podst.vkových domů“ se zaměřuje na vývoj krajiny a zmapování podst.vkových domů v Brtníkách, v malé vesničce na severu děčínského okresu. První část článku se věnuje samotnému vzniku sídla a vývoji sídelní struktury, druhá část pak samotné analýze brtnických podst.vkových domů, které spoluurčují a charakterizují zdejší malebnou krajinu.
Dexamethasone Intravitreal Implant (Ozurdex)
Authors: CADTH  
Published: March 2023

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses Dexamethasone (Ozurdex) 0.7 mg intravitreal implant.
Indication: For the treatment of adult patients with diabetic macular edema who are pseudophakic.
Longevity of Partial and Complete Dentures
Authors: Khangura Sara D. , Grobelna Aleksandra , Haas Robyn , Subramonian Anusree 
Published: March 2023

Removable complete dentures may last for an average of 10.06 years, with most complete dentures lasting for at least 5 years.
Most metal partial dentures may last for at least 5 years.
We did not identify any studies that met inclusion criteria for our report describing the longevity of removable plastic partial dentures.
The included studies did not report populations, interventions, and outcomes clearly or consistently. This made some of the findings difficult to interpret.
Bringing a Poem to a Gunfight
Authors: Singh Shubhangi 
Published: March 2023

The contribution has been reworked and re-versioned from the video work, Bringing a Poem to a Gunfight (2021).
Bringing a Poem to a Gunfight looks at armours and bodies and puts forth the two parallel inquiries within the discourse on movement, visibility, control and identity. It inquires if public safety automatically equals nation building by the way of militarization.
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Shubhangi Singh’s practice ranges from moving image, text, lecture-performances and installations. Her work often draws upon existing knowledges to address movement, identity and queries related to the body and its relationship with its environment.
Singh considers ideas of absence and absenting in her work as a way of reflecting upon what is visible, particularly in relation to memory, the labour of memorialising and history.
QUANTIFYING SULFUR DISPERSION USING POPULATION SURVIVAL ANALYSIS OF TENSILE STRENGTH
Authors: Wong Dominica H. C. , Ignatz-Hoover Frederick , Childress Ashley , Jackson Grayson L. , Padmakumar Amrish 
Published: March 2023

ABSTRACT
High-performance rubber compounds require good dispersion of polymers, fillers, and other additives. However, fine powdery additives such as zinc oxide and insoluble sulfur (IS) are characteristically difficult to disperse, and poor dispersion may lead to large crosslink and modulus gradients in the final vulcanizate. IS dispersion can be assessed directly or indirectly, yet many techniques suffer from a lack of sensitivity and accuracy or are cost prohibitive. Herein, we describe the application of a two-parameter Weibull distribution and population survival analysis of cured rubber tensile strength as a simple technique to evaluate IS dispersion. We use statistical tools to determine the optimum number of sample replicates required to differentiate the quality of dispersion in rubber articles through the Weibull scale and shape estimates (α and β, respectively). We then demonstrate how mixing cycle time and intensity affect the dispersion of two IS grades and show that judicious choice of IS can lead to reduced cycle mix times, productivity improvements, and energy cost savings.
Threats Detection in IoT Network
Authors: ABU KWAİDER Hanan , AVAROĞLU Erdinç 
Published: March 2023

The recent growth in Internet of Things (IoT) deployment has increased the rapidness of integration and extended the reach of the internet from computers, tablets, and phones to countless devices in our physical world. This growth makes our life more convenient and industries more efficient. However, at the same time, it brought numerous challenges in terms of security and expanded the area of cyber-attacks, especially the DoS and DDoS attacks. Moreover, since many IoT devices run custom or outdated operating systems, and most do not have enough resources to run typical intrusion detection systems, it was necessary to search for alternative solutions. Therefore, many researchers have joined the race to develop new lightweight intrusion detection methods. In this study, we have investigated the detection of different DoS attacks on the IoT network using machine learning techniques. The studied attacks are TCP Syn-Flood Attack, UDP Flood Attack, HTTP Slowloris GET Attack, Apache Range Header DoS, and Port Scan attack. We have proposed a new dataset, namely HEIoT21, which was generated in a real smart home environment using a collective of IoT devices and non-IoT devices connected to a wireless network. The proposed dataset included normal and anomaly data, and using the CiCflowmeter application, we extracted 82 network features from the proposed dataset. The dataset was labeled and categorized into binary-class and multi-class. Our dataset underwent multiple feature selection methods to keep only enough features to produce a good detection accuracy; for that, we have used Anova F-value Feature Selection, Random Forest importance feature selection, and Sequential Forward Feature Selection. The feature selection techniques produced three new sub-datasets, which were evaluated using multiple machine learning algorithms like Logistic Regression (LR), J48 Decision Tree (DT), Naïve Bayes, and Artificial Neural Network (ANN). A comparison study was conducted on the result obtained from applying the different machine learning algorithms on the derived sub-datasets, which led to the finding that the most suitable feature selection technique for the proposed dataset was Anova F-value and the best-fit machine learning algorithm for the proposed dataset was The Decision Tree which produced an accuracy result of 99.92% for binary classification and 99.94% for multi-class classification.
In the end, our study was compared with other studies in the field of IoT intrusion detection, and we found that the result obtained through this study was higher than most others. Therefore, the proposed dataset could be of great use to those who want to work on the analysis and detection of the existing network security threats. Also, this study can be considered a cornerstone for a proper lightweight intrusion detection system, where the datasets can be expanded to include other types of attacks, new detection rules can be added, and an alert mechanism can be integrated to become a complete detection system.