bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction and simulation of mechanical properties of borophene-reinforced epoxy nanocomposites using molecular dynamics and FEA
Authors: Banerjee Nirvik , Sen Abhishek , Ghosh Partha S. , Biswas Amit R. , Sharma Shubham , Kumar Abhinav , Singh Rajesh , Li Changhe , Kaur Jatinder , Eldin Sayed M. 
Published: July 2023

Abstract
The purpose of this work is to predict the mechanical properties of single- to few-layered borophene (η-LB)/epoxy composites using molecular dynamics modelling. An epoxy matrix was used to hold borophene in layers, and a borophene sheet was homogeneously incorporated into the epoxy matrix to generate borophene/epoxy nanocomposites. In this work, the mechanical properties of borophene/epoxy nanocomposites have been analysed in further detail. In addition to the mechanical properties of the nanocomposites, the impacts of borophene on the density distribution of epoxy polymers in the nanocomposites led to the observation that the local density is relatively high near the borophene–β12 interface and gradually declines to the bulk value as one advances away from the interface. The mechanical properties of the borophene-layered nanocomposites were superior to those of their substitutes, with the former having a higher Young’s modulus and a lower thermal expansion coefficient. This is due to the fact that borophene layer loading may result in a significant quantity of high-density polymer being present in the nanocomposites, which enhances the overall properties of the nanocomposites. In addition, the interaction between the three to four layers of loaded borophene layer provides the greatest reinforcement among the two nanocomposites systems. Finite element analysis analyses on the preferred results of the β12 LB were in excellent agreement with those of the experimental simulation data, demonstrating that this computational technique may be used to reliably predict the characteristics of borophene/epoxy composites in the future.
Evaluating Different Covariate Balancing Methods: A Monte Carlo Simulation
Authors: Fukui Hideki 
Published: July 2023

Abstract
We investigate the effectiveness of five weighting and matching techniques, including propensity score matching (PSM), in improving covariate balance and reducing bias when estimating treatment effects in finite-sample situations through Monte Carlo simulations. King and Nielsen (2019. “Why Propensity Scores Should Not Be Used for Matching.” Political Analysis 27 (4): 435–54) argue that pruning observations based on PSM with 1-to-1 greedy matching can worsen rather than improve covariate balance and can increase the bias in the estimates of treatment effects. In our simulations, we observed this phenomenon not only in PSM with 1-to-1 greedy matching but also in other covariate balancing techniques that King and Nielsen (2019. “Why Propensity Scores Should Not Be Used for Matching.” Political Analysis 27 (4): 435–54) recommend as better matching methods, i.e. Mahalanobis distance matching (MDM) and coarsened exact matching (CEM). Regardless of the weighting/matching techniques and the data generation processes in this study, our findings indicate that matching and weighting under extreme caliper or cut-point settings does not improve covariate balance. In addition, once a substantially improved covariate balance is achieved in a given sample, the estimated bias tends to worsen slightly as the covariate balance continues to improve. Moreover, our simulation results suggest that OLS with proper covariates reduces selection bias as well as other weighting and matching methods. The results suggest that when analyzing observational data, it is important to avoid looking for a one-size-fits-all estimator and to identify the appropriate nonexperimental estimator carefully for the sample by thoroughly investigating the available data’s characteristics.
Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
Authors: Rattigan Kevin M , Zarou Martha M , Brabcova Zuzana , Prasad Bodhayan , Zerbst Désirée , Sarnello Daniele , Kalkman Eric R , Ianniciello Angela , Scott Mary T , Dunn Karen , Shokry Engy , Sumpton David , Copland Mhairi , Tardito Saverio , Vande Voorde Johan , Mussai Francis , Cheng Paul , Helgason G Vignir 
Published: July 2023

AbstractTo fuel accelerated proliferation, leukaemic cells undergo metabolic deregulation, which can result in specific nutrient dependencies. Here, we perform an amino acid drop‐out screen and apply pre‐clinical models of chronic phase chronic myeloid leukaemia (CML) to identify arginine as a nutrient essential for primary human CML cells. Analysis of the Microarray Innovations in Leukaemia (MILE) dataset uncovers reduced ASS1 levels in CML compared to most other leukaemia types. Stable isotope tracing reveals repressed activity of all urea cycle enzymes in patient‐derived CML CD34+ cells, rendering them arginine auxotrophic. Thus, arginine deprivation completely blocks proliferation of CML CD34+ cells and induces significantly higher levels of apoptosis when compared to arginine‐deprived cell lines. Similarly, primary CML cells, but not normal CD34+ samples, are particularly sensitive to treatment with the arginine‐depleting enzyme, BCT‐100, which induces apoptosis and reduces clonogenicity. Moreover, BCT‐100 is highly efficacious in a patient‐derived xenograft model, causing > 90% reduction in the number of human leukaemic stem cells (LSCs). These findings indicate arginine depletion to be a promising and novel strategy to eradicate therapy resistant LSCs.
Platelet‐derived lipids promote insulin secretion of pancreatic β cells
Authors: Karwen Till , Kolczynska‐Matysiak Katarzyna , Gross Carina , Löffler Mona C , Friedrich Mike , Loza‐Valdes Angel , Schmitz Werner , Wit Magdalena , Dziaczkowski Filip , Belykh Andrei , Trujillo‐Viera Jonathan , El‐Merahbi Rabih , Deppermann Carsten , Nawaz Sameena , Hastoy Benoit , Demczuk Agnieszka , Erk Manuela , Wieckowski Mariusz R , Rorsman Patrik , Heinze Katrin G , Stegner David , Nieswandt Bernhard , Sumara Grzegorz 
Published: July 2023

AbstractHyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism. Pancreatic β cells are the central regulators of systemic glucose homeostasis. Here, we show that factor(s) derived from β cells stimulate platelet activity and platelets selectively localize to the vascular endothelium of pancreatic islets. Both depletion of platelets and ablation of major platelet adhesion or activation pathways consistently resulted in impaired glucose tolerance and decreased circulating insulin levels. Furthermore, we found platelet‐derived lipid classes to promote insulin secretion and identified 20‐Hydroxyeicosatetraenoic acid (20‐HETE) as the main factor promoting β cells function. Finally, we demonstrate that the levels of platelet‐derived 20‐HETE decline with age and that this parallels with reduced impact of platelets on β cell function. Our findings identify an unexpected function of platelets in the regulation of insulin secretion and glucose metabolism, which promotes metabolic fitness in young individuals.
Implementasi Orhiba Di Mahad Al-Zaytun Pada Masa Pandemi Covid-19
Authors: Sobirin Sobirin , Santoso Budi 
Published: July 2023

The Corona Virus Disease outbreak, also known as the Corona virus or Covid-19, is an acute respiratory syndrome disease that has spread to nearly every country in the world, infecting and killing many people. Education is one aspect of life that has been affected by this epidemic. The Indonesian government enforces online or online learning to prevent transmission. Nonetheless, an educational institution known as the Al Zaytun Campus continues to provide face-to-face instruction while adhering to health protocols and implementing numerous innovations. The innovations implemented are referred to as ORHIBA (New Life Order). The topic of this paper is therefore "ORHIBA Implementation at Mahad Al Zaitun During the Covid-19 Pandemic." Using a phenomenological research methodology, this study aims to determine how ORHIBA is implemented on the Al Zaytun campus. From the research findings, it was determined that there were changes to a healthier lifestyle than usual, while still adhering to WHO health standards in handling Covid-19, in addition to a number of innovations in various sectors that produced better results. It is hoped that this way of life will serve as a model for other locations, including the government, which is presently implementing the New Normal way of life.Keywords: Strategy; ORHIBA; Covid-19 Pandemic AbstrakWabah Penyakit Virus Corona, juga dikenal sebagai virus Corona atau Covid-19, adalah penyakit sindrom pernafasan akut yang telah menyebar ke hampir setiap negara di dunia, menginfeksi dan membunuh banyak orang. Pendidikan merupakan salah satu aspek kehidupan yang terkena imbas dari wabah ini. Pemerintah Indonesia memberlakukan pembelajaran daring atau online untuk mencegah penularan. Meski demikian, lembaga pendidikan yang dikenal dengan nama Kampus Al Zaytun ini tetap memberikan pengajaran tatap muka dengan tetap mematuhi protokol kesehatan dan menerapkan berbagai inovasi. Inovasi yang diterapkan disebut sebagai ORHIBA (Tatanan Hidup Baru). Makalah ini diangkat dengan topik “Implementasi ORHIBA di Mahad Al Zaitun Selama Pandemi Covid-19”. Dengan menggunakan metodologi penelitian fenomenologi, penelitian ini bertujuan untuk mengetahui bagaimana implementasi ORHIBA di kampus Al Zaytun. Dari hasil penelitian diketahui adanya perubahan pola hidup yang lebih sehat dari biasanya, dengan tetap berpegang pada standar kesehatan WHO dalam penanganan Covid-19, selain sejumlah inovasi di berbagai sektor yang membuahkan hasil lebih baik. Cara hidup seperti ini diharapkan dapat menjadi percontohan bagi daerah lain, termasuk pemerintah yang saat ini menerapkan cara hidup New Normal.Kata Kunci: Strategi; ORHIBA; Pandemi Covid-19
Analisis Desentralisasi Asimetris Pada Pengangkatan Penjabat (PJ) Gubernur Provinsi DKI Jakarta
Authors: Asmui Asmui , Furqon Abdil Azizul , Maggalatung A. Salman , Rambe Mara Sutan , Ikhsan Muh. , Fadli Ahmad Risyad 
Published: July 2023

One of the impacts arising from the implementation of simultaneous elections and elections is the existence of vacancies in regional heads in several provinces and districts. To fill the vacancy, an Acting PJ was appointed by the Government. Rapture acting regional head as stipulated in the provisions of Article 201 paragraph (9) of the Law 10 of 2016 raises questions about its application in the DKI Jakarta Provincial Government. As regions with a special status different from other regional governments, Jakarta places the Governor with great authority, including appointing and dismissing the Mayor and Regent in Article 29 of 2007, which is indeed placed as an acting administrative task. Because of that great authority, the mechanism for electing the Governor of DKI Jakarta is more specialized, namely meeting the number of votes 50%, and if it is not fulfilled, a second round of elections will be held. This is done so that The governor elected by the people is truly of the will of the majority of the people because later the Governor has great authority. Given the specificity possessed by DKI Jakarta Government, hence the application of Article 201 paragraph (9) of Law Number 10 of 2016 is questionable, especially from its constitutionality.Keywords: Simultaneous Elections; Asymmetric Decentralization; Acting Regional Heads; DKI Jakarta AbstrakSalah satu dampak yang muncul dari pelaksanaan pemilu dan pemilukada serentak adalah adanya kekosongan jabatan pada kepala daerah di beberapa provinsi dan kabupaten. Sebagai upaya untuk mengisi kekosongan jabatan tersebut, maka diangkat Penjabat (PJ) oleh Pemerintah. Pengangkatan Penjabat (PJ) Kepala Daerah sebagaimana diatur dalam ketentuan Pasal 201 ayat (9) Undang-Undang 10 Tahun 2016 menimbulkan pertanyaan penerapannya di Pemerintah Provinsi DKI Jakarta. Sebagai daerah yang memiliki status kekhususan yang berbeda dengan pemerintahan daerah lain, DKI Jakarta menempatkan Gubernur dengan kewenangan yang besar, termasuk mengangkat dan memberhentikan Walikota dan Bupati yang dalam desain Undang-Undang Nomor 29 Tahun 2007, memang ditempatkan sebagai pelaksana tugas administratif. Karena kewenangan yang besar itu, mekanisme pemilihan Gubernur DKI Jakarta lebih dikhususkan lagi yaitu memenuhi jumlah suara 50%, dan jika tidak terpenuhi akan dilakukan putaran kedua pemilihan. Hal tersebut dilakukan agar Gubernur yang dipilih oleh masyarakat adalah benar-benar dari kehendak mayoritas masyarakat sebab nantinya Gubernur memiliki kewenangan yang besar. Mengingat kekhususan yang dimiliki Pemerintahan DKI Jakarta, maka penerapan Pasal 201 ayat (9) Undang-Undang Nomor 10 Tahun 2016 patut dipertanyakan terutama dari konstitusionalitasnya.Kata Kunci: Pemilu Serentak; Desentralisasi Asimetris; Penjabat Kepala Daerah; DKI Jakarta
The Urgency of Mediation in the Religious Courts
Authors: Hidayat Asep Syarifuddin 
Published: July 2023

This article addresses the necessity of using mediation in religious courts as a means of conflict resolution because it is proven to be both effective and helpful. In the context of resolving economic disputes according to Sharia law, mediation is an essential component in the process of bringing the opposing parties together to find a solution that is equitable and conducive to peaceful coexistence. This article describes the scope of mediation in religious courts. It discusses the several types of problems that can be handled by mediation, including business, contractual, and inheritance disagreements. In addition, the concepts of mediation that have been embraced by religious courts, such as the values of liberty, volunteering, and confidentiality, are explained below. The research method that was employed was a qualitative research method that used an approach that was based on both the literature and legislative requirements. According to the findings of recent research, the use of mediation in the process of conflict resolution can result in significant time, financial, and resource savings while also contributing to the preservation of amicable relations between the disputants. This article also provides a list of various case studies and empirical evidence that support the benefits of mediation within the setting of religious courts.Keywords: Mediation; Religious courts; Dispute Abstrak:Artikel ini membahas perlunya penggunaan mediasi di pengadilan agama sebagai sarana penyelesaian konflik karena terbukti efektif dan membantu. Dalam konteks penyelesaian sengketa ekonomi menurut hukum syariah, mediasi merupakan komponen penting dalam proses mempertemukan pihak-pihak yang bertikai untuk mencari solusi yang adil dan kondusif bagi hidup berdampingan secara damai. Artikel ini memberikan gambaran tentang ruang lingkup mediasi di peradilan agama. Ini membahas beberapa jenis masalah yang dapat ditangani oleh mediasi, antara lain masalah bisnis, perselisihan kontrak, dan perselisihan warisan. Selain itu, konsep-konsep mediasi yang dianut oleh peradilan agama seperti nilai-nilai kebebasan, kerelawanan, dan kerahasiaan dijelaskan di bawah ini. Metode penelitian yang digunakan adalah metode penelitian kualitatif yang menggunakan pendekatan yang didasarkan pada literatur dan persyaratan peraturan perundang-undangan. Menurut temuan penelitian terbaru, penggunaan mediasi dalam proses penyelesaian konflik dapat menghasilkan penghematan waktu, keuangan, dan sumber daya yang signifikan sementara juga berkontribusi pada pelestarian hubungan damai antara pihak yang berselisih. Artikel ini juga memberikan daftar berbagai studi kasus dan bukti empiris yang mendukung manfaat mediasi dalam lingkungan peradilan agama.Kata Kunci: Mediasi; Pengadilan Agama; Sengketa
Islam dan Doktrin Ekonomi
Authors: Zaki Muhammad 
Published: July 2023

Islam is a revelation sent down by Allah SWT. to His apostles to regulate all aspects of life both vertically and horizontally which contain broad guidance for life, while at the same time giving essential values to that life. Islam also means obedience, obedience to the will and law of Allah SWT. and fear Him who was sent down to organize human life in this world and the hereafter. Islamic teachings originate from the Quran, sunnah and ijtihad. The main points of Islamic teachings are believing in God Almighty, believing in the day of resurrection and giving charity, doing good deeds, and avoiding evil deeds. In general, the rules in Islam cover three main things, namely aqidah, sharia, and morals. Islam positions economic activity as one of the important aspects to gain glory (falah), and therefore the economic activity needs to be guided and controlled so that it goes in tune with Islamic teachings. Economic activity can only lead to falah as long as it is carried out based on Islamic beliefs and is colored by Islamic morality.Keywords: Islam, Economic activity, Falah. AbstrakIslam merupakan wahyu yang diturunkan oleh Allah swt. kepada rasul-Nya untuk mengatur segala aspek hidup baik vertikal maupun horizontal yang berisi tuntunan kehidupan secara luas, sekaligus memberikan nilai-nilai esensial pada kehidupan tersebut. Islam juga berarti sebagai kepatuhan, ketaatan terhadap kehendak dan hukum Allah swt. dan bertaqwa kepada-Nya yang diturunkan untuk menata kehidupan manusia di dunia dan akhirat. Ajaran-ajaran Islam bersumber dari Alquran, sunnah dan ijtihad. Pokok-pokok ajaran Islam adalah beriman kepada Tuhan Yang Maha Esa, mengimani hari kebangkitan dan pembalasan amal, melakukan amal-amal kebajikan, dan menjauhi perbuatan-perbuatan yang jahat. Secara umum aturan dalam Islam meliputi tiga hal pokok, yakni aqidah, syariah, dan akhlak. Islam memosisikan kegiatan ekonomi sebagai salah satu aspek penting untuk mendapatkan kemuliaan (falah), dan karenanya kegiatan ekonomi perlu dituntun dan dikontrol agar berjalan seirama dengan ajaran Isla. Kegiatan ekonomi hanya mampu membawa kepada falah selama dilaksanakan berdasarkan akidah Islam dan diwarnai dengan moral Islam.Kata kunci: Islam, Aktifitas ekonomi, Falah.
Versenysportolók hirtelen szívhalálának elemzése, az esetszámok csökkentésének lehetőségei
Authors: Major Zsuzsanna , Medvegy Zoltán , Tulit Tímea Terézia , Simonyi Gábor , Pavlik Gábor , Medvegy Mihály 
Published: July 2023

Bevezetés: A sportolói hirtelen szívhalál ritka (0,5–1/100 000
sportolói év), de az ismert sportolók hirtelen szívhalála általános
megrázkódtatást okoz. Célkitűzés: Kutatási célunk volt
összegyűjteni és tanulmányozni minél több hirtelenszívhalál-esetet, megítélni a
stressz szerepét és keresni a tragédiák csökkentésének lehetőségeit.
Módszer: Az interneten talált regiszterekből,
újságcikkekből kigyűjtöttünk 360 (köztük 14 nő) olyan sportolói hirtelen
szívhalált, amelynél a sportág, az életkor és a halál helye
(edzésen/versenyen/ezeket követően) megállapítható volt. Ezekből a halál évszáma
szerinti sorrendben egységes adatbázist készítettünk, amelyet készséggel
bocsátunk az érdeklődők rendelkezésére. Az eseteket sportágak szerint
csoportosítottuk, elemeztük. Eredményeink és irodalmi adatok alapján a tragédiák
csökkentése céljából javaslatokat tettünk. Eredmények és
következtetés: Versenyen több hirtelen szívhalál történt, mint
edzésen (239 vs. 99), de fizikai terheléssel nem járó
bemelegítés és sakkozás közben is történtek tragédiák, viszont a
maraton/félmaraton/triatlon sportolók tét nélküli edzésein nem volt hirtelen
szívhalál. Mindezek a stressz szerepét bizonyítják, ezért nagy tétű verseny
előtt pszichológiai beszélgetést ajánlunk. A csapatsportok edzésein is sok
(79/360) hirtelen szívhalál történt, ezért már ott is javaslunk reanimációs
készenlétet. Edzés/verseny után hirtelen szívhalál elsősorban a nagy statikus
erőkifejtést igénylő sportágakban történt, ott a versenyek utáni megfigyelés is
ajánlott. Az edzéseken meghalt sportolók fiatalabbak voltak a verseny közben
elhunytakhoz képest (p<0,01), ezért az edzéseken a fiatalokat fokozottan kell
orvosi és (alul)edzettségi szempontból figyelni. A maratonfutók és a
triatlonosok idősebbek voltak a csapatsportolóknál (p<0,005), és csak
versenyen haltak meg, ezért náluk verseny előtt is ajánlott egy alapvizsgálat és
1 hónapon belüli EKG. Irodalmi adatokból levont következtetések: a sportorvosi
vizsgálat egységesítése és hozzáférhető dokumentálása lenne szükséges; mivel a
hamarabb és szakszerűen megkezdett újraélesztés eredményesebb, minden versenyző
kapjon reanimációs oktatást. Orv Hetil. 2023; 164(29): 1155–1163.
Research and Nonresearch Industry Payments to Nephrologists in the United States between 2014 and 2021
Authors: Murayama Anju , Kamamoto Sae , Kugo Hinari , Saito Hiroaki , Ozaki Akihiko 
Published: July 2023

Significance Statement
Concerns about the financial relationships between nephrologists and the health care industry have been reported in the United States over the past decade. However, since the 2014 launch of the federal transparency database, Open Payments, few documents have explored the whole picture of research and nonresearch payments to US nephrologists from industry sources. In this study, the authors found that 87% of nephrologists have received nonresearch payments, and the aggregate amount of these payments has been increasing since 2014. Only 12% of nephrologists received research payments; these recipients were disproportionately male. In addition, the top 5% of nephrologists receiving nonresearch funds received 81% of all such payments. Nonresearch payments were larger among male nephrologists than among female nephrologists and increased by 8% annually among male nephrologists between 2014 and 2019.

Background
Financial relationships between nephrologists and the health care industry have been a concern in the United States over the past decade.

Methods
To evaluate industry payments to nephrologists, we conducted a cross-sectional study examining nonresearch and research payments to all US nephrologists registered in the National Plan and Provider Enumeration System between 2014 and 2021, using the Open Payments database. Payment data were descriptively analyzed on the basis of monetary value, and payment trends were evaluated by using a generalized estimating equations model.

Results
From 2014 through 2021, 10,463 of 12,059 nephrologists (87%) received at least one payment from the US health care industry, totaling $778 million. The proportion of nephrologists who did not receive nonresearch payments varied each year, ranging from 38% to 51%. Nonresearch payments comprised 22% ($168 million) of overall industry payments in monetary value but 87% in the number of payments. Among those receiving payments, the median per-physician 8-year aggregated payment values were $999 in nonresearch payments and $102,329 in associated research payments. Male nephrologists were more likely than female nephrologists to receive research payments, but the per-physician amount did not differ. However, nonresearch payments were three times larger for male nephrologists and increased by 8% annually between 2014 and 2019 among male nephrologists but remained stable among female nephrologists. The top 5% of nephrologists receiving nonresearch payments received 81% of all such payments.

Conclusions
Between 2014 and 2021, 87% of US nephrologists received at least one payment from the health care industry. Notably, nonresearch payments to nephrologists have been increasing since the Open Payments database's 2014 launch. Male nephrologists were more likely than female nephrologists to receive research payments.