bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of hyper IgE with herpetic viral encephalitis and ecthyma gangrenosum in a male Egyptian patient
Authors: Ibrahim Hamdi , Maksod Safwat Abdel , Khorshed Magdy , Rady Hanan , Haron Marwa , Alkassas Omar , Alsisi Ahmed , Said Suzan , ALfishawy Mostafa , Mohamed Adel 
Published: January 2023

AbstractThere are two forms of hyper-immunoglobulin E syndromes (HIES): a dominant form (AD-HIES) is caused by mutations in signal transducer and activator of transcription 3 (STAT3), and a recessive form (AR-HIES) is caused by mutations in dedicator of cytokinesis 8 (DOCK8). DOCK8 autosomal recessive hyper IgE syndrome (AR-HIES) patients have a more symptomatic neurologic disease than those with STAT3 deficiency. Involvement of the central nervous system in patients with HIES has been rarely reported. Being a rare primary immuno-deficiency, the disease may be underdiagnosed and under-reported. In the central nervous system abnormalities with definite neurologic manifestations, very few articles were published previously which may vary from hemiplegia to partial facial nerve paralysis in children and acute disseminated encephalomyelitis (ADEM), but viral encephalitis has not been reported. Herein, we describe a 21-year-old male with hyper-immunoglobulin E syndrome presented with fever, pneumonia, skin abscesses, and altered consciousness who proved to have herpetic viral encephalitis. The purpose of this study is to emphasize that neurologic complications with herpetic viral encephalitis may occur in patients with hyper IgE syndrome. In the case series, no cases of hyper IgE were described to have viral encephalitis, and to the best of our knowledge, this is the first description of herpes simplex encephalitis in a patient with hyper IgE syndrome.
Target Trial Emulation: A Design Tool for Cancer Clinical Trials
Authors: Kwee Sandi A. , Wong Linda L. , Ludema Christina , Deng Chris K. , Taira Deborah , Seto Todd , Landsittel Douglas 
Published: January 2023

PURPOSE To apply target trial emulation to explore the potential impact of eligibility criteria on the primary outcome of a randomized controlled trial. METHODS Simulations of a real-world explanatory trial of transarterial radioembolization for advanced unresectable hepatocellular carcinoma with portal vein invasion were performed to examine the effects of cohort specification on survival outcomes and patient sample size. Simulations comprised 24 different permutations of the trial varied on three disease nonspecific eligibility parameters. Treatment and control arms for these emulated trials were drawn from the National Cancer Database and matched by treatment propensity. Target trial emulation served as the causal framework for this analysis, allowing the architecture of a true controlled experiment to address forms of bias routinely encountered in comparative effectiveness studies involving real-world observational data. RESULTS Twenty-four propensity score–matched cohorts comprising a wider clinical spectrum of patients than specified by the original target trial were successfully generated using the National Cancer Database. The arms for each of the emulated trials demonstrated exchangeability across all eligibility criteria and other clinical covariates. Significant treatment benefits were associated with only a narrow range of eligibility criteria, indicating that the original target trial was well specified. CONCLUSION The impact of patient selection on treatment outcomes can be studied using target trial emulation. This analytical framework can furthermore serve to leverage existing real-world data to inform the task of cohort specification for a randomized controlled trial, facilitating a more data-driven approach for this important step in clinical trial design.
Axiomatic de Sitter quantum Yang-Mills theory with color confinement and mass gap
Authors: Takook M. V. 
Published: January 2023

Abstract
The analyticity property of de Sitter's quantum Yang-Mills theory in the framework of Krein space quantization, including quantum metric fluctuation, is demonstrated. This property completes our previous work regarding quantum Yang-Mills theory in de Sitter's ambient space formalism, and we can construct an axiomatic quantum field theory similar to Wightman's axioms. The color confinement is proven for the general case, which was previously approved in the early universe. It is shown by using the interaction between gluon fields and the conformal sector of the gravitational field, which is a massless minimally coupled scalar gauge field. The gluon mass results from the interaction between the gluon fields and the massless minimally coupled scalar field as a conformal sector of the gravitational field and then the symmetry-breaking setting due to the vacuum expectation value of the scalar field.
Geometric latches enable tuning of ultrafast, spring-propelled movements
Authors: Longo Sarah J. , St. Pierre Ryan , Bergbreiter Sarah , Cox Suzanne , Schelling Benjamin , Patek S. N. 
Published: January 2023

ABSTRACT
The smallest, fastest, repeated-use movements are propelled by power-dense elastic mechanisms, yet the key to their energetic control may be found in the latch-like mechanisms that mediate transformation from elastic potential energy to kinetic energy. Here, we tested how geometric latches enable consistent or variable outputs in ultrafast, spring-propelled systems. We constructed a reduced-order mathematical model of a spring-propelled system that uses a torque reversal (over-center) geometric latch. The model was parameterized to match the scales and mechanisms of ultrafast systems, specifically snapping shrimp. We simulated geometric and energetic configurations that enabled or reduced variation of strike durations and dactyl rotations given variation of stored elastic energy and latch mediation. Then, we collected an experimental dataset of the energy storage mechanism and ultrafast snaps of live snapping shrimp (Alpheus heterochaelis) and compared our simulations with their configuration. We discovered that snapping shrimp deform the propodus exoskeleton prior to the strike, which may contribute to elastic energy storage. Regardless of the amount of variation in spring loading duration, strike durations were far less variable than spring loading durations. When we simulated this species' morphological configuration in our mathematical model, we found that the low variability of strike duration is consistent with their torque reversal geometry. Even so, our simulations indicate that torque reversal systems can achieve either variable or invariant outputs through small adjustments to geometry. Our combined experiments and mathematical simulations reveal the capacity of geometric latches to enable, reduce or enhance variation of ultrafast movements in biological and synthetic systems.
A gelatin-based feed for precise and non-invasive drug delivery to adult zebrafish
Authors: Ochocki Aleksander J. , Kenney Justin W. 
Published: January 2023

ABSTRACT
Although the use of adult zebrafish as a model organism has increased in recent years, there is room to refine methods, such as drug delivery, to make them less invasive and more precise. Here, we describe the development of a non-invasive gelatin-based feed method that is tailored to animals based on their body mass. The feed was readily eaten by zebrafish (&lt;1 min) with minimal leaching of compound when placed in water (&lt;5% in 5 min). As a proof of principle, we fed fish a NMDA receptor antagonist (MK-801, 4 mg kg−1) prior to the novel tank test. We found that MK-801 caused a general decrease in predator-avoidance/anxiety-like behavior (bottom dwelling) and an increase in locomotion in male fish, but not females. Our simple, easy to prepare and individually tailored gelatin-based feed enables precisely dosed, non-invasive drug delivery to adult-stage zebrafish for the first time.
Assessment of renal allograft rejection with diffusion tensor imaging
Authors: Das Chandan Jyoti , Kubihal Vijay , Kumar Sambuddha , Agarwal Sanjay Kumar , Dinda Amit Kumar , Sreenivas Vishnubhatla 
Published: January 2023

Objectives: To investigate the value of DTI in differentiation of renal allograft rejection from well-functioning stable allograft, using fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values. Methods: In this prospective study, 22 transplant recipients with well-functioning stable allograft (group A) and 20 patients with renal allograft rejection (group B + C) were recruited over a period of 19 months from January 2018 to July 2019. DTI-MRI was performed in all the patients, and FA and ADC values were measured in cortical and medullary regions of the transplanted kidney. On biopsy, graft rejection was classified as acute (group B) (n = 7) and chronic graft rejection (group C) (n = 13) based on the BANNF scoring system. Statistical analysis was performed using STATA v.14.0. Results: Statistically significant difference between group A and group B + C was noted for cortical (p < 0.001), and medullary (p = 0.003) FA values, and cortical (p = 0.020), and medullary (p = 0.046) ADC values. Cortical(p < 0.001) and Medullary(p = 0.020) FA values showed statistically significant difference between group A and group C, and cortical FA value(p = 0.012) also showed statistically significant difference between group B and group C. AUC (to differentiate between renal allograft rejection and well-functioning stable allograft) for cortical, and medullary FA values and cortical and medullary ADC values were 0.853(p < 0.001), 0.757(p = 0.004), 0.709(p = 0.021) and 0.736(p = 0.009), respectively. Conclusion and Advances in knowledge: DTI is a promising functional MRI technique for the non-invasive assessment of renal allograft function. Diffusion parameters, such as FA and ADC values, can be useful in the differentiation of renal allograft rejection from well-functioning stable allograft.
Aircraft Conflict Resolution: A Benchmark Generator
Authors: Pelegrín Mercedes , Cerulli Martina 
Published: January 2023

Aircraft conflict resolution is one of the major tasks of computer-aided air traffic management and represents a challenging optimization problem. Many models and methods have been proposed to assist trajectory regulation to avoid conflicts. However, the question of testing the different mathematical optimization approaches against each other is still open. Standard benchmarks include unrealistic scenarios in which all the flights move toward a common point or completely random generated instances. There is a lack of a common set of test instances that allows comparison of the available methods under a variety of heterogeneous and representative scenarios. We present a flight deconfliction benchmark generator that allows the user to choose between (i) different predefined scenario inspired by existing benchmarks in the literature; (ii) pseudo-random traffic meeting certain congestion measurements; (iii) and randomly generated traffic. The proposed setting can account for different levels of difficulty in the deconfliction of the aircraft and allows to explore and compare the real limitations of optimization approaches for aircraft conflict resolution. History: Accepted by Ted Ralphs, area editor for Software Tools. Funding: This work was supported by the H2020 Marie Skłodowska-Curie Actions [Grant 764759 ITN “MINOA”]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.1265 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2021.0283 ) at ( http://dx.doi.org/10.5281/zenodo.7377734 ).
De-Crypto-ing Signals in Initial Coin Offerings: Evidence of Rational Token Retention
Authors: Davydiuk Tetiana , Gupta Deeksha , Rosen Samuel 
Published: January 2023

Using the market for initial coin offerings (ICOs) as a laboratory, we provide evidence that entrepreneurs use retention to alleviate information asymmetry. The underlying technology and the absence of regulation make the ICO market well suited to study this question empirically. Using a hand-collected data set, we show that ICO issuers that retain a larger fraction of their tokens are more successful in their funding efforts and are more likely to develop a working product. Moreover, we find that retention is a stronger signal when markets are crowded, and investors do not have as much time to conduct due diligence. This paper was accepted by Will Cong, Special Section of Management Science: Blockchains and Crypto Economics. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2022.4631 .
On the Effect of Symmetry Requirement for Rendezvous on the Complete Graph
Authors: Bonamy Marthe , Pilipczuk Michał , Sereni Jean-Sébastien , Weber Richard 
Published: January 2023

We consider a classic rendezvous game in which two players try to meet each other on a set of n locations. In each round, every player visits one of the locations, and the game finishes when the players meet at the same location. The goal is to devise strategies for both players that minimize the expected waiting time till the rendezvous. In the asymmetric case, when the strategies of the players may differ, it is known that the optimum expected waiting time of [Formula: see text] is achieved by the wait-for-mommy pair of strategies, in which one of the players stays at one location for n rounds, while the other player searches through all the n locations in a random order. However, if we insist that the players are symmetric—they are expected to follow the same strategy—then the best known strategy, proposed by Anderson and Weber [Anderson EJ, Weber RR (1990) The rendezvous problem on discrete locations. J. Appl. Probab. 27(4):839–851], achieves an asymptotic expected waiting time of [Formula: see text]. We show that the symmetry requirement indeed implies that the expected waiting time needs to be asymptotically larger than in the asymmetric case. Precisely, we prove that for every [Formula: see text], if the players need to employ the same strategy, then the expected waiting time is at least [Formula: see text], where [Formula: see text]. We propose in addition a different proof for one our key lemmas, which relies on a result by Ahlswede and Katona [Ahlswede R, Katona GOH (1978) Graphs with maximal number of adjacent pairs of edges. Acta Mathematica Academiae Scientiarum Hungaricae 32(1–2):97–120]: the argument is slightly shorter and provides a constant larger than [Formula: see text], namely, [Formula: see text]. However, it requires that n be at least 16. Both approaches seem conceptually interesting to us. Funding: This work is a part of project TOTAL (Mi. Pilipczuk) that has received funding from the European Research Council under the European Union’s Horizon 2020 research and innovation program [Grant 677651]. It is also partially funded by French ANR projects [Grant ANR-16-CE40-0023] (DESCARTES) and [Grant ANR-17-CE40-0015] (DISTANCIA).
A General Framework for Bandit Problems Beyond Cumulative Objectives
Authors: Cassel Asaf , Mannor Shie , Zeevi Assaf 
Published: January 2023

The stochastic multiarmed bandit (MAB) problem is a common model for sequential decision problems. In the standard setup, a decision maker has to choose at every instant between several competing arms; each of them provides a scalar random variable, referred to as a “reward.” Nearly all research on this topic considers the total cumulative reward as the criterion of interest. This work focuses on other natural objectives that cannot be cast as a sum over rewards but rather, more involved functions of the reward stream. Unlike the case of cumulative criteria, in the problems we study here, the oracle policy, which knows the problem parameters a priori and is used to “center” the regret, is not trivial. We provide a systematic approach to such problems and derive general conditions under which the oracle policy is sufficiently tractable to facilitate the design of optimism-based (upper confidence bound) learning policies. These conditions elucidate an interesting interplay between the arm reward distributions and the performance metric. Our main findings are illustrated for several commonly used objectives, such as conditional value-at-risk, mean-variance trade-offs, Sharpe ratio, and more. Funding: This work was partially funded by the Israel Science Foundation [Contract 2199/20] and by the European Community’s Seventh Framework Programme FP7/2007–2013 [Grant 306638 (Scaling Up Reinforcement Learning: Structure Learning, Skill Acquisition, and Reward Shaping)].
The Day-to-Day Departure Time Choice of Heterogeneous Commuters Under an Anonymous Toll Charge for System Optimum
Authors: Guo Ren-Yong , Yang Hai , Huang Hai-Jun 
Published: January 2023

We consider a bottleneck system in a state of disequilibrium, in which commuters are heterogeneous in the values of travel time and schedule delays. Three representative dynamical systems are used to formulate the day-to-day departure time choice of commuters, and a Walrasian toll charge scheme is utilized to control the evolutionary process of traffic flows. The toll charge scheme is anonymous; that is, toll charges are identical for all user classes, and the scheme’s implementation does not need to resort to information on the values of travel time and schedule delays. We find that the system optimum (SO) flow pattern can be achieved at the stationary state under the implementation of the toll charge scheme. The equivalence between the stationary state and the SO, the existence of the toll charge for achieving the SO, and the convergence of day-to-day traffic flows to the SO under the implementation of the toll charge scheme are theoretically proved. The distributions of traffic flows and toll charges at the SO state during morning rush hour are analytically shown. The application of the toll charge scheme to a network with multiple trip origins is presented. The effectiveness of the toll charge scheme for achieving the SO is also examined by numerical analyses. Funding: This work was supported by the National Natural Science Foundation of China [Grants 72171007, 71890972/71890970, and 72021001]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2022.1191 .
Improving quality of cassava peel meal as raw material for tilapia feed
Authors: Putra Achmad Noerkhaerin , Indayah Unah , Nokiyah Nokiyah , Syamsunarno Mas Bayu 
Published: January 2023

Cassava peel meal (CPM) has potential as a raw material for fish feed due to its abundant availability and good nutritional content. The high crude fiber content inhibits the use of CPM as a raw material for fish feed. Therefore, this study aims to evaluate the effect of Aspergillus niger fermentation of CPM on dietary nutrient digestibility and growth performance of tilapia (Oreochromis niloticus). It was conducted in 2 stages. The first stage was a fermentation process of CPM, which used a factorial randomized design consisting of a dose difference of A. niger, namely 10, 15, 20, 30 g.kg-1 and a fermentation time of 0, 12, 24 hours with 3 replications each. At a dose of 1.5% of A. niger during 24 hours of fermentation, the crude fiber content of fermented CPM was reduced up to 7.19%. the second stage was a 45 days feeding trial on tilapia used a completely randomized design consisting of 3 different treatments with 3 replications, namely: reference feed, unfermented cassava peal meal based diet (CPMD), and A. niger fermented CPMD. A. niger fermented CPMD showed an increase in growth, dry matter, protein, energy, and raw material digestibility, as well as daily growth rate compared to unfermented CPMD. The daily growth rate of fermented CPMD of 1.32%/day was significantly higher with P0.05 than the unfermented CPMD of 0.72%/day. Furthermore, the digestibility value of material test in the fermented CPMD (48.73%) was significantly higher (P0.05) than unfermented CPMD (11.74%). These results indicate that A. niger fermented CPM has the potential to be used as raw material for tilapia fish feed. Keywords:Aspergillus nigerFermentationTilapiaCrude fiber
Analysis of changes in mangrove ecosystems in Banda Aceh city 17 years after the 2004 tsunami
Authors: Gogo Maulana , Abdullah Faisal , Syahreza Saumi , Budi Muhammad 
Published: January 2023

Mangrove has the most important role especially in the coastal area. The existence of mangrove habitats in Banda Aceh which got decreasing and loss after tsunami disaster in 2004. The purpose of this study was to the distribution of mangrove in Banda Aceh divided into five (5) sub districts including Jaya Baru, Kuta Alam, KutaRaja, Meuraxa, and Syiah Kuala. This study the mangrove changes after tsunami 2004, began from 2005, 2010, 2015, and 2022. The main data used in this study are Landsat 5 and Sentinel 2A images. Methods of image processing applied in this study are NDVI analysis and supervised classification-based image classification. Theresults are able to show the changes of mangrove area in Banda Aceh from 2004 to 2022. Mangrove area in 2005 is 28.89 ha, 2010 is 81.38 ha, 2015 is 180.27 ha, and 2022 is 121.34 ha. It can be seen that there is a decreasing of mangrove area from 2015 to 2022. The analysis results are also able to show that Kuta raja sub district has the largest mangrove area of 60.11 ha or 49.54 % of the overall area. According to the overall results, it can be said that remote sensing satellite images such as Landsat and Sentinel 2A are very useful in conducting the spatio-temporal research from the long-term periods. This study is hoped to be able to become a reference data in efforts to restore the mangrove in Banda Aceh in order to create the sustainable ecosystem area.Keywords:Mangrove ecosystemsRestorationNDVISupervised classificationSpatio temporal
Description scleractinian coral from Miang Island, East Kalimantan
Authors: Rosdianto Rosdianto , El Rahimi Sayyid Afdhal , Kryk Adrian , Arsad Sulastri , Luthfi Oktiyas Muzaky , Luthfi M Azurea Bahri 
Published: January 2023

The exact number of coral species in Indonesia is not unclear yet, in 2002 the coral taxonomist, JEN Veron, stated 590 species, and it was supported by an Indonesian coral taxonomist, Suharsono, eight years later. The current coral species data is 605 but it is from Coral Triangle Region area (CT). The eastern of Indonesia, which is located in the Coral Triangle Region, has received a lot of attention from coral researchers, due to coral species that have been described. On the other hand, the coral reef from the western part of Indonesia, including in the East Kalimantan, has not been explored much in recent times. Through the ecoregion view, E. Kalimantan region is clustered into ecoregion 43 (Sulu Sea) which has 540 coral species. Miang Island is one of the inhabited islands from E. Kalimantan, and has an unexplored coral reef ecosystem. The method had been used in this research is descriptive, which uses photos of live corals to describe colony characteristics corals. The results of the study have described 36 species of coral and several invertebrates that make up coral reefs on Miang Island.Keywords:Hard coralAcroporaPoritesIdentificationPulau Miang