bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Overview of Uncertain Control Co-Design Formulations
Authors: Azad Saeed , Herber Daniel R. 
Published: June 2023

Abstract
This article explores various uncertain control co-design (UCCD) problem formulations. While previous work offers formulations that are method-dependent and limited to only a handful of uncertainties (often from one discipline), effective application of UCCD to real-world dynamic systems requires a thorough understanding of uncertainties and how their impact can be captured. Since the first step is defining the UCCD problem of interest, this article aims at addressing some of the limitations of the current literature by identifying possible sources of uncertainties in a general UCCD context and then formalizing ways in which their impact is captured through problem formulation alone (without having to immediately resort to specific solution strategies). We first develop and then discuss a generalized UCCD formulation that can capture uncertainty representations presented in this article. Issues such as the treatment of the objective function, the challenge of the analysis-type equality constraints, and various formulations for inequality constraints are discussed. Then, more specialized problem formulations such as stochastic in expectation, stochastic chance-constrained, probabilistic robust, worst-case robust, fuzzy expected value, and possibilistic chance-constrained UCCD formulations are presented. Key concepts from these formulations, along with insights from closely-related fields, such as robust and stochastic control theory, are discussed, and future research directions are identified.
Aero-Thermal Analysis of Rarefied Flow Over Inverse Cone Shaped Objects Using Direct Simulation Monte Carlo Analysis
Authors: Sharma Vatsalya , Assam Ashwani 
Published: June 2023

Abstract
When an object undergoes atmospheric entry, it experiences drag and heat load over its surface which determines its trajectory and ability to survive the hostile flow conditions. This work performs numerical analysis using direct simulation Monte Carlo (DSMC) simulations to study key flow features and properties on a cone-shaped body. The cone is created by varying the angle of extrusion (α) of the flat-nosed face of a cylinder in positive and negative directions. Detailed analysis of the key flow features is conducted, and the results of the distribution of surface heat transfer and drag coefficient on each of the negative α are contrasted against the results obtained for zero and positive α for which compressible flow physics are well defined. For α≤45 deg, heat flux increases with an increase in α, while the total drag experienced by the body decreases. Meanwhile, when α is increased in the negative direction, an inverse cone is formed, which creates a cavity inside the body, and the body decelerates more with an increasing magnitude of α. In contrast, the wall heat flux inside the cone remains quite low. These conditions allow the body to maintain a significantly low temperature during high-speed flow, like in the case of planetary entry, in comparison with the high temperature resulting in α≤0 deg cases. The present study also helps to improve the understanding of optimum cone-shaped space objects from the perspective of drag and heat flux.
Transient Temperature Distribution in a Half-Space Due to Local Surface Heating Via Non-Fourier Fractional Dual-Phase-Lag Model
Authors: Zhang Xue-Yang , Hu Ying , Li Xian-Fang 
Published: June 2023

Abstract
The non-Fourier heat transfer in a half-space is analyzed under sudden heating or cooling on a local surface. The non-Fourier heat transfer effect is described by the time-fractional dual-phase-lag (DPL) model, where the fractional derivative without singular kernel is used. An axisymmetric mixed initial-boundary value problem is solved by the use of the Hankel and Laplace transforms. Two typical cases of sudden temperature rising on a circular zone of the surface or an instantaneous surface heat source are analyzed. For sudden temperature rises, the heat flux and temperature gradient exhibit an inverse square-root singularity near the boundary of the heating zone and their dynamic intensity factors are computed numerically in the time domain. For the instantaneous surface point heat source, an exact solution of the transient temperature at any position in the Laplace domain is obtained. The effects of the fractional order and relaxation time on the temperature distribution and heat flux response are elucidated. The singular behavior of the transient thermal response and the non-Fourier effect of heat transfer are shown.
Magma migration and surface uplift in Pamir–western Tibet driven by deep lithospheric dynamics
Authors: Tang Gong-Jian , Wyman Derek A. , Dan Wei , Wang Qiang , Gadoev Mustafo , Oimahmadov Ilhomjon 
Published: June 2023

Abstract
There are two parallel &gt;1200-km-long semi-continuous (ultra)potassic magmatic belts in the southern (Karakorum-Lhasa) and the northern (Central Pamir–western Kunlun) parts of Pamir–western Tibet. The southern belt is widely attributed to northward subduction of the Indian plate, while it has been suggested that the northern belt relates to the southward subduction of the Asian plate. We report new zircon U-Pb ages and isotopic data for the northern belt that show eastward magma migration between ca. 20 Ma and the present, which are contemporaneous with continental-scale thermochronometric cooling ages. Whereas magma migration in the south was caused by progressive west-to-east Indian lithosphere break-off, magma generation in the north is shown to be related to asthenospheric mantle upflow through a small mantle window (~100 km width) forced by Indian lithosphere underthrusting, Pamir–western Tibet lithosphere mantle dripping, and resistance of the Tarim lithosphere. Northern belt magma migration relates to progressively eastward underthrusting of the Indian lithosphere that took ~15 m.y. to move northward across ~350 km to meet Asian lithosphere. Accordingly, both belts of (ultra)potassic magmatism relate to the northward subduction of the Indian plate that was responsible for plateau uplift in Pamir–western Tibet.
Cross-country and panel data estimates of the price elasticity of demand for cigarettes in Europe
Authors: Kohler Andreas , Vinci Linda , Mattli Renato 
Published: June 2023

ObjectiveOur goal is to provide estimates of the price elasticity of demand for cigarettes in Europe as a basis for public health policy on tobacco taxation.MethodsWe use secondary data on cigarette retail sales including illicit trade, prices, tobacco control measures and income from 2010 to 2020 of 27 European countries from Euromonitor, the WHO, the Tobacco Control Scale and the World Bank. We estimate the price elasticity of demand using instrumental variable regressions as well as panel data regressions taking into account that prices and quantities are determined simultaneously in the market.ResultsBased on cross-section data at the country level, we find that during the decade from 2010 to 2020, the demand for cigarettes in Europe has become neither more nor less elastic. Our estimates of the price elasticity based on panel data are around −0.4 (95% CI −0.67 to –0.24), in line with previous estimates for high-income countries. Furthermore, our analysis shows that estimates of the price elasticity of demand that are based on data including illicit trade tend to be lower. This has also been found in the previous literature.ConclusionsBy providing state-of-the-art, up-to-date estimates of the price elasticity of demand that are in line with the previous literature, we show that taxation can still be a cost-effective tobacco policy to reduce cigarette consumption and thus, the burden of smoking.
Systems science methods in public health: what can they contribute to our understanding of and response to the cost-of-living crisis?
Authors: Höhn Andreas , Stokes Jonathan , Pollack Roxana , Boyd Jennifer , Chueca Del Cerro Cristina , Elsenbroich Corinna , Heppenstall Alison , Hjelmskog Annika , Inyang Elizabeth , Kopasker Daniel , Sonthalia Shreya , Thomson Rachel M , Zia Kashif , Katikireddi Srinivasa Vittal , Meier Petra 
Published: June 2023

BackgroundMany complex public health evidence gaps cannot be fully resolved using only conventional public health methods. We aim to familiarise public health researchers with selected systems science methods that may contribute to a better understanding of complex phenomena and lead to more impactful interventions. As a case study, we choose the current cost-of-living crisis, which affects disposable income as a key structural determinant of health.MethodsWe first outline the potential role of systems science methods for public health research more generally, then provide an overview of the complexity of the cost-of-living crisis as a specific case study. We propose how four systems science methods (soft systems, microsimulation, agent-based and system dynamics models) could be applied to provide more in-depth understanding. For each method, we illustrate its unique knowledge contributions, and set out one or more options for studies that could help inform policy and practice responses.ResultsDue to its fundamental impact on the determinants of health, while limiting resources for population-level interventions, the cost-of-living crisis presents a complex public health challenge. When confronted with complexity, non-linearity, feedback loops and adaptation processes, systems methods allow a deeper understanding and forecasting of the interactions and spill-over effects common with real-world interventions and policies.ConclusionsSystems science methods provide a rich methodological toolbox that complements our traditional public health methods. This toolbox may be particularly useful in early stages of the current cost-of-living crisis: for understanding the situation, developing solutions and sandboxing potential responses to improve population health.
Penumbra-targeted CircOGDH siRNA-loaded nanoparticles alleviate neuronal apoptosis in focal brain ischaemia
Authors: Liu Yanfang , Zhang Tianyuan , Zou Xing , Yuan Zhongwen , Li Yufeng , Zang Jiankun , He Niu , He Lizhen , Xu Anding , Lu Dan 
Published: June 2023

BackgroundNanoparticles (NPs) are a class of substances that can be loaded with therapeutic agents delivered to specific areas. In our earlier research, we identified a neuron-derived circular RNA (circRNA), circular oxoglutarate dehydrogenase (CircOGDH), as a promising therapeutic target for acute ischaemic stroke. This study dedicated to explore a prospective preliminary strategy of CircOGDH-based NP delivered to the ischaemic penumbra region in middle cerebral artery occlusion/reperfusion (MCAO/R) mice.MethodsImmunofluorescence in primary cortex neurons and in vivo fluorescence imaging revealed endocytosis of Poly(lactide-co-glycolide) (PLGA) poly amidoamine(PAMAM)@CircOGDH small interfering RNA (siRNA) NPs. Western blotting analysis and CCK8 assay were performed to evaluate the apoptotic level in ischaemic neurons treated with PLGA–PAMAM@CircOGDH siRNA NPs. Quantitative reverse transcription PCR experiments, mice behaviour test, T2 MRI analysis, Nissl and TdT-mediated dUTP nick end labeling (TUNEL) co-staining were performed to evaluate the apoptosis level of ischaemic penumbra neurons in MCAO/R mice. Biosafety evaluation of NPs in MCAO/R mice was detected by blood routine examination, liver and kidney function examination and HE staining.ResultsPLGA–PAMAM@CircOGDH siRNA NPs were successfully assembled. Endocytosis of PLGA–PAMAM@CircOGDH siRNA NPs in ischaemic neurons alleviated neuronal apoptotic level in vitro and in vivo. Furthermore, mice behaviour test showed that the neurological defects of MCAO/R mice were significantly alleviated after the tail injection of PLGA–PAMAM@CircOGDH siRNA NPs, and no toxic effects were observed.ConclusionIn conclusion, our results suggest that PLGA–PAMAM@CircOGDH siRNA NPs can be delivered to the ischaemic penumbra region and alleviate neuron apoptosis in MCAO/R mice and in ischaemic neurons; therefore, our study provides a desirable approach for using circRNA-based NPs for the treatment of ischaemic stroke.
Cause-specific mortality in COPD subpopulations: a cohort study of 339 647 people in England
Authors: Whittaker Hannah , Rothnie Kieran J , Quint Jennifer K 
Published: June 2023

BackgroundIdentifying correlates of cause-specific mortality in patients with chronic obstructive pulmonary disease (COPD) may aid the targeting of therapies to reduce mortality. We determined factors associated with causes of death in a primary care COPD population.MethodsClinical Practice Research Datalink Aurum was linked to Hospital Episode Statistics and death certificate data. People with COPD alive between 1 January 2010 and 1 January 2020 were included. Patient characteristics were defined before the start of follow-up: (a) frequency and severity of exacerbations; (b) emphysema or chronic bronchitis; (c) Global Obstructive Lung Disease (GOLD) groups A–D; and (d) airflow limitation. We used Cox Proportional Hazards regression and competing risks to investigate the association between patient characteristics and risk of all-cause, COPD and cardiovascular (CV) mortality.Results339 647 people with COPD were included of which 97 882 died during follow-up (25.7% COPD related and 23.3% CV related). Airflow limitation, GOLD group, exacerbation frequency and severity, and COPD phenotype were associated with all-cause mortality. Exacerbations, both increased frequency and severity, were associated with COPD-related mortality (≥2 exacerbations vs none adjusted HR: 1.64, 1.57–1.71; 1 severe vs none adjusted HR: 2.17, 2.04–2.31, respectively). Patients in GOLD groups B–D had a higher risk of COPD and CV mortality compared with GOLD group A (GOLD group D vs group A, adjusted HR for COPD mortality: 4.57, 4.23–4.93 and adjusted HR for CV mortality: 1.53, 1.41–1.65). Increasing airflow limitation was also associated with both COPD and CV mortality (GOLD 4 vs 1, adjusted HR: 12.63, 11.82–13.51 and adjusted HR: 1.75, 1.60–1.91, respectively).ConclusionPoorer airflow limitation, worse functional status and exacerbations had substantial associations with risk of all-cause mortality. Differing results for CV and COPD-related mortality suggests interventions to prevent mortality may need to target particular characteristics or time points in the disease course.
Perspectives on laser-plasma physics in the relativistic transparency regime
Authors: King Martin , Wilson Robbie , Bacon Ewan F. J. , Dolier Ewan J. , Frazer Timothy P. , Goodman Jack , Gray Ross J. , McKenna Paul 
Published: June 2023

AbstractWith the advent of multi-petawatt lasers, the relativistic transparency regime of laser-plasma interactions becomes readily accessible for near-solid density targets. Initially opaque targets that undergo relativistic self-induced transparency (RSIT) have already shown to result in promising particle acceleration and radiation generation mechanisms, as well as relativistic optical and photonics phenomena that modify the spatial, temporal, spectral and polarization properties of the laser pulse itself. At the maximum laser intensities currently available, this opaque-to-RSIT transition regime can be achieved through ultrafast ionization, heating and expansion of initially ultrathin foil targets. Here, we review findings from our programme of work exploring this regime experimentally and numerically, including changes to the laser energy absorption, mechanisms for laser-driven particle acceleration and the generation of a relativistic plasma aperture. New physics induced by this aperture, such as the production of intense light with higher order spatial modes and higher harmonics, and spatially-structured and temporally-varying polarization states, is summarized. Prospects for exploring the physics of the RSIT regime with higher intensity and high repetition rate lasers, including expected new phenomena such as high-field effects and the application of new techniques such as machine learning, are also discussed; outlining directions for the future development of this promising laser-plasma interaction regime.
Perivascular Macrophages Mediate Microvasospasms After Experimental Subarachnoid Hemorrhage
Authors: Lin Xiangjiang , Khalin Igor , Harapan Biyan Nathanael , Terpolilli Nicole Angela , Schwarting Julian , Plesnila Nikolaus 
Published: June 2023

BACKGROUND:
Subarachnoid hemorrhage (SAH) is characterized by acute and delayed reductions of cerebral blood flow (CBF) caused, among others, by spasms of cerebral arteries and arterioles. Recently, the inactivation of perivascular macrophages (PVM) has been demonstrated to improve neurological outcomes after experimental SAH, but the underlying mechanisms of protection remain unclear. The aim of our exploratory study was, therefore, to investigate the role of PVM in the formation of acute microvasospasms after experimental SAH.

METHODS:

PVMs were depleted in 8- to 10-week-old male C57BL/6 mice (n=8/group) by intracerebroventricular application of clodronate-loaded liposomes and compared with mice with vehicle liposome injections. Seven days later, SAH was induced by filament perforation under continuous monitoring of CBF and intracranial pressure. Results were compared with sham-operated animals and animals who underwent SAH induction but no liposome injection (n=4/group each). Six hours after SAH induction or sham surgery, numbers of microvasospasms per volume of interest and % of affected pial and penetrating arterioles were examined in 9 standardized regions of interest per animal by in vivo 2-photon microscopy. Depletion of PVMs was proven by quantification of PVMs/mm
3
identified by immunohistochemical staining for CD206 and Collagen IV. Statistical significance was tested with
t
tests for parametric data and Mann-Whitney
U
test for nonparametric data.

RESULTS:

PVMs were located around pial and intraparenchymal arterioles and were effectively depleted by clodronate from 671±28 to 46±14 PVMs/mm
3
(
P
<0.001). After SAH, microvasospasms was observed in pial arteries and penetrating and precapillary arterioles and were accompanied by an increase to 1405±142 PVMs/mm
3
. PVM depletion significantly reduced the number of microvasospasms from 9 IQR 5 to 3 IQR 3 (
P
<0.001).

CONCLUSIONS:
Our results suggest that PVMs contribute to the formation of microvasospasms after experimental SAH.
Qohelet as Divine Hedonist
Authors: Sneed Mark 
Published: June 2023

Abstract
This paper will demonstrate that the best descriptor of Qohelet is divine hedonist, not absurdist, skeptic, pessimist, realist, nihilist or “Preacher of Joy.” This will be done by examining the relationship between Qohelet’s hebel-judgments and his carpe diem ethic and comparing Qohelet’s strategy with that of philosopher David Hume. Qohelet’s hebel-judgments serve to deconstruct the traditional formulation of the Tun-Ergehen-Zusammenhang, opening space for legitimating his preferred ethic: the carpe diem. In other words, Qohelet rhetorically paints a dark and dreary world in order to buttress his main ethic, the carpe diem, an ethic that is both hedonistic (using philosophical classification) in seeking pleasure and avoiding pain (reflected in his God-fearing motif), and divine in that this ethic must align with God’s mysterious decrees.
A New Look at Abigail’s Wisdom
Authors: Schwartz Sarah 
Published: June 2023

Abstract
This paper offers a new look at the design of Abigail’s character as a wise woman in 1 Sam 25, based on an analysis of the argumentative component of Abigail’s speech and the connections between her speech and the book of Proverbs. According to this analysis, Abigail is not only portrayed as a rescuer, but is also designed in the image of the wise educator in the book of Proverbs, who teaches David a fundamental theological principle about relying on God instead of on his own strength—despite the essential legitimacy to harm Nabal. This message is relevant to David’s status as an anointed king de jure, but as a refugee de facto. David’s adherence to Abigail’s message designs his character as a wise person who is willing to learn, indicating that the narrative justifies David’s monarchy through his encounter with Abigail.
Seasonal variation in the land hermit crab, Coenobita rugosus H. Milne Edwards, 1837 (Decapoda, Anomura) and a preliminary study of land hermit crabs as a bioindicator of turtle nesting at Penghu County Wang-An Island green turtle nesting refuge, Taiwan
Authors: Hsu Chia-Hsuan , Fang Wei-Ta , Jiang Bing-Rong , Chai Lei , Kao Wei-Cheng , Huang Tsung-Shun 
Published: June 2023

Abstract
The present study surveyed the land hermit crab species, body size, shell type, and shell suitability, at five sites over four seasons in the Penghu County Wang-an Island Green Turtle Nesting Refuge. Coenobita rugosus H. Milne Edwards, 1837 was the only species recorded and found at three sites (Tiantai Hill, Xi’an Reservoir, and Tudigong). The density index of hermit crabs exhibited notable variations across the sites, showing no significant variation with the changing seasons. The bush habitat displayed a higher density index compared to the sand habitat. Additionally, the sites differed significantly in terms of the shell type and body size of the hermit crabs. Further, no significant relationship was established between abundance and weather factors or between crab abundance and sea turtle nesting. This investigation is a preliminary examination of the possibility of land hermit crabs being used as bioindicators for breeding of sea turtles.
The Humours and the Dyes
Authors: Raggetti Lucia 
Published: June 2023

Abstract
This contribution presents the edition and translation of a new manuscript witness to the Arabic tradition of Galenic summaries On urine (MS Collegesville, Minnesota HMML olm 00041). Uroscopy appears to be a complementary diagnostic element in ancient medicine, which gained increasing popularity in later centuries, as attested by the rich traditions in Greek and Arabic. The summary, as attested in this manuscript witness, compares the four bodily humours to dyes, creating a concrete and tangible frame for the study and memorization of this diagnostic branch. This text, moreover, stresses the performative dimension of uroscopy, particularly in the form of instructions for physicians on how to recognize devious fake samples offered by obnoxious people seeking to test the physician in order to undermine his authority and credibility.
The Search for the Tang Royal Domain (Wangji 王畿)
Authors: Wu Chia-Yun 
Published: June 2023

Abstract
This essay discusses how the traditional Chinese geographical concept Nine Domains (Jiufu 九服) was applied in Yixing’s 一行 (683–727) large-scale gnomonic survey of the Tang dynasty. Yixing’s surveying method is reconstructed by comparing textual records with schematic delineations. This comparison shows that the centralized and symmetrical pattern in the arrangement of survey sites conforms to the visual and schematic delineations of the concept of Nine Domains. The design was meant to show that the Earth was in harmony with heavenly patterns, thus confirming Emperor Xuanzong of Tang’s 唐玄宗 mandate of heaven to govern. In this essay, I lay out Yixing’s empirical scientific work and symbolic cultural activity regarding calendrical reform to re-establish the legitimacy of the Tang dynasty regime. The case demonstrates an understanding of how Chinese astronomers interrelated Heaven and Earth and indicates an ongoing tension in the history of science about concept-practice relations.