bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enabling health potential: exploring nonlinear and complex results of osteopathic manual medicine through complex systems theory
Authors: Ching Leslie M. , Benjamin Bruce A. , Stiles Edward G. , Shaw Harriet H. 
Published: January 2023

AbstractOsteopathic medicine is a holistic, patient-specific approach. Explaining the impact of osteopathic manipulative medicine (OMM) has been problematic because many of its effects are nonlinear. Complex systems theory (CST) is explored as a mechanism of understanding the interplay of the body’s anatomy and physiology, an illness process, and the effects of OMM. Tensegrity is discussed as an example of an emergent property of the body’s systems that affects not only biomechanics but also pathophysiology. Previous explanations of osteopathic philosophy are reviewed. The Host + Disease=Illness paradigm is a way to think through the impact of host and disease factors on an illness state, and how targeted interventions may affect the illness. The Osteopathic 5 Models are another way to view the body’s complexity. The area of greatest restriction (AGR) screen can be understood to direct OMM in a way that respects complexity and enables asymmetric and nonlocal results to realize health potential. The impact of this framework is in coherently explaining the impact of osteopathic philosophy and OMM and exploring new approaches to research.
Study on pathogen spectrum of 1,046 hospitalized children with respiratory tract infections during COVID-19
Authors: Han Xin-Yuan , Wang Xue-Ling , Zhang Jin , Gong Xue-Lei , Kan Li-Juan , Wei Jie-Hong , Zhang Xiu-Ming 
Published: January 2023

Abstract

Objectives
This study aimed to describe the pathogen spectrum of bacteria and viruses of RTIs in hospitalized children during the Coronavirus disease 2019 (COVID-19) epidemic in Shenzhen.

Methods
From October 2020 to October 2021, the results of pathogenic tests causing RTIs were retrospectively analyzed in hospitalized children in Shenzhen Luohu Hospital Group.

Results
829 sputum samples for bacterial isolation and 1,037 nasopharyngeal swabs for virus detection in total. The positive detection rate (PDR) of bacteria was 42.1%. Staphylococcus aureus (18.8%) was the predominant bacteria detected in positive cases, with Moraxella catarrhalis (10.9%), Streptococcus pneumoniae (9.5%) following. The PDR of the virus was 65.6%. The viruses ranking first to third were Human Rhinovirus (HRV), Respiratory syncytial virus (RSV), and Human Parainfluenza (HPIV), with rates of 28.0, 18.1, and 13.5%, respectively. Children under 3 years were the most susceptible population to RTIs. The pathogens of S. aureus, M. catarrhalis, S. pneumoniae, HRV, and HPIV were more prevalent in autumn. Meanwhile, RSV had a high rate of infection in summer and autumn. S. aureus and HRV had higher co-infection rates.

Conclusions
Our findings demonstrate the pathogen spectrum of 1,046 hospitalized children with RTIs in Shenzhen, China, during the COVID-19 outbreak.
Nano-kirigami enabled chiral nano-cilia with enhanced circular dichroism at visible wavelengths
Authors: Liu Xing , Liang Qinghua , Zhang Xiaochen , Ji Chang-Yin , Li Jiafang 
Published: January 2023

AbstractNano-kirigami method enables rich diversity of structural geometries that significantly broaden the functionalities of optical micro/nano-devices. However, the methodologies of various nano-kirigami are still limited and as a result, the chiral nano-kirigami structure has yet been pushed to the limit for operation at visible wavelength region. Here, the merits of the various nano-kirigami strategies are comprehensively explored and bio-inspired nano-cilia metasurface with enhanced circular dichroism at visible wavelengths is demonstrated. The stereo chiral nano-cilia metasurface is designed with three-fold rotational symmetry, which exhibits tuneable chiroptical responses when the nano-cilia are deformed to form strong chiral light–matter interactions. By employing electron-beam lithography (EBL) and focused ion beam (FIB) lithography, on-chip nano-cilia metasurfaces are experimentally realized in near-infrared wavelengths region and at visible wavelengths, respectively, successfully validating the giant circular dichroism revealed in simulations. Our work is useful to broaden the existing platform of micro/nano-scale manufacturing and could provide an effective method for the realization of versatile bioinspired nanostructures with profound chiroptical responses.
A broadband, self-powered, and polarization-sensitive PdSe2 photodetector based on asymmetric van der Waals contacts
Authors: Zhang Xuran , Dai Mingjin , Deng Wenjie , Zhang Yongzhe , Wang Qi Jie 
Published: January 2023

Abstract
Self-powered photodetectors with broadband and polarization-sensitive photoresponse are desirable for many important applications such as wearable electronic devices and wireless communication systems. Recently, two-dimensional (2D) materials have been demonstrated as promising candidates for self-powered photodetectors owing to their advantages in light–matter interaction, transport, electronic properties, and so on. However, their performance in speed, broadband response, and multifunction is still limited. Here, we report a PdSe2 photodetector with asymmetric van der Waals (vdWs) contacts formed by using a homojunction configuration. This device achieves a high responsivity approaching 53 mA/W, a rise/decay time of about 0.72 ms/0.24 ms, and a detectivity of more than 5.17 × 1011 Jones in the visible-near infrared regime (532–1470 nm). In addition, a linear polarization-sensitive response can be observed with an anisotropy ratio of 1.11 at 532 nm and 1.62 at 1064 nm. Furthermore, a strong anisotropic response endows this photodetector with outstanding polarization imaging capabilities, realizing a contrast-enhanced degree of linear polarization imaging. Our proposed device architecture demonstrated the great potential of PdSe2-based asymmetric vdWs contacts for high-performance photodetectors operating without any external bias.
Implementation of an enhanced recovery program for complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a referral center: a case control prospective study
Authors: Charleux-Muller Diane , Fabacher Thibaut , Romain Benoit , Meyer Nicolas , Brigand Cécile , Delhorme Jean-Baptiste 
Published: January 2023

Abstract

Objectives
Current recommendations regarding enhanced recovery programs (ERPs) after complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are based on a low level of evidence. The aim of this study is to evaluate the effect of implementing an adapted ERP for CCRS and HIPEC in a referral center.

Methods
We conducted a study with a prospective group of 44 patients (post-ERP group) who underwent CCRS with HIPEC between July 2016 and June 2018, the period during which ERP was implemented. This group was compared to a second retrospective group of 21 patients who underwent CCRS with HIPEC between June 2015 and June 2016, during which ERP was not yet implemented (pre-ERP group).

Results
The ERP compliance rate was 65% in the post-ERP group. The hospital length of stay (HLS) was shorter in the post-ERP group: 24.9 days (IQR 11–68, pre-ERP group) vs. 16.1 days (IQR 6–45, post-ERP group), as was the major morbidity rate (pre-ERP group=33.3% vs. post-ERP group=20.5%). The nasogastric tube, urinary catheter and abdominal drains were all retrieved faster in the post-ERP group.

Conclusions
The implementation of an adapted ERP after CCRS with HIPEC procedures reduces morbidity and shortens the HLS.
Development of purification of no-carrier-added 47Sc of theranostic interest: selective separation study from the natTi(n,p) process
Authors: Rizk Hoda E. , Breky Mohamed M. E. , Attallah Mohamed F. 
Published: January 2023

Abstract
Scandium-47 is one of the most promising medical radioisotopes, and its production and trace separation make it an attractive candidate for theranostic application. In this study, the production of no-carrier-added (NCA) 47Sc through the natTi(n,p) reaction and subsequent purification using liquid–liquid extraction was done for the theranostic application. The comparative separation of NCA 47Sc after the dissolution of an activated Ti target using Di-2-Ethylhexyl Phosphoric Acid (HDEHP) in kerosene was evaluated. The extraction process was optimized in terms of the concentration of extractant, extraction time, pH, and reaction temperature to achieve the maximum possible separation. HDEHP is efficient and promising for rapid extraction and separation of NCA 47Sc from Ti ions at low acidity (pH 0.85) with high extraction percent (>99%), contaminated with 22.3% of Ti ions after 5 min of extraction time. Different stripping reagents were used to separate loaded 47Sc and Ti ions. Firstly, 5 M HCl was enough for stripping the loaded Ti ions. Then the loaded 47Sc was separated with a purity of 100% using 0.05 M NaOH. The obtained results find the HDEHP a promising extractant for efficient separation of 47Sc from irradiated Ti target for preparing the 47Sc radiopharmaceuticals for theranostics applications.
Screening the in vitro Antimicrobial and Antioxidant Activities of Methanolic Extract of Epiphyllum oxypetalum (DC.) Haw. Leaf
Authors: Mahmad Afzan , Teh Ubaidah  , Salim Fatimah , Shaharun Maizatul Shima 
Published: January 2023

Epiphyllum oxypetalum (E. oxypetalum) is traditionally used to cure liver infections, for wound healing, and to alleviate viral–related diseases. However, as the alcohol and aqueous solvents have low total phenolic and flavonoid content (TPC and TFC), antioxidant, and antibacterial capabilities, a different polarity would be more suitable. Thus, this study aimed to evaluate the methanolic extract of E. oxypetalum leaf. The chemical constituents were identified through TPC and TFC, as well as GC–MS analysis. The methanolic extract of E. oxypetalum leaf was evaluated for antimicrobial properties against five bacterial strains - Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, and a fungal strain of Candida albicans using the disc diffusion method. The antioxidant activity of the methanolic extract of E. oxypetalum leaf was also assessed using DPPH assay. The highest values of the TPC and TFC of the methanolic extract of E. oxypetalum leaf were 179.86 ± 0.17 mg GAE/g and 75.07 ± 0.17 mg QE/g, respectively. The GC–MS had 27 m/z peaks, indicating the presence of various bioactive compounds including phenolic compounds and fatty acids. In the antimicrobial study, the zone of inhibition (ZOI) was between 2.8–3.5 mm for antibacterial activity and there was also a significant antifungal activity of 1.8 mm against Candida albicans. The IC50 DPPH assay value of methanolic extract of E. oxypetalum leaf was 14 µg/ml, indicating high antioxidant properties. This study provides evidence that the methanolic extract of E. oxypetalum leaf possesses significant antioxidant and antimicrobial properties which could be attributed to its diverse chemical constituents. These findings suggest the potential of E. oxypetalum leaf as a natural source of medicine, antimicrobial, and antioxidant properties.
-Based Virtual Screening Towards The Discovery of Usnic Acid Derivatives as Novel mTOR Inhibitor to Treat Breast Cancer
Authors: Wong Kelvin Khai Voon , Natasya Baharudin Nurul Farina , Roney Miah , Mohd Aluwi Mohd Fadhlizil Fasihi 
Published: January 2023

In this study, mTOR is chosen as the main target for breast cancer treatment. While the existing drugs still pose severe side effects, research on finding new anti-cancer drug should be done continuously. Usnic acid (UA) has been studied for its wide range of biological properties and potential in pharmaceutical research. A structure-based virtual screening approach is applied since it could reduce production time, cost and environmental issues. This study comprises molecular docking simulation, ADMET filtration and drug-likeness prediction. 340 UA derivatives were retrieved from literature and used to build an in-house database. The resulting compounds from docking were then filtered using ADMET prediction which comprises human intestine absorption, aqueous solubility, plasma protein binding, cytochrome P450 2D6 (CYP2D6) and hepatotoxicity parameters to identify the most potent UA derivatives with favourable physicochemical characteristics. After all, the hit compound, 118, was further stimulated in order to forecast its drug-like features. The chalcone-based scaffold of 118 resembled the reported breast cancer compound’s chemical structure strengthening the results obtained from this study. Thus, it is concluded that the structure-based virtual screening was an efficient and effective approach in the discovery of UA derivative, 118, as a potential novel mTOR inhibitor to treat breast cancer.
Die Wiener Weltausstellung 1873. •
Authors: Ujvári Hedvig 
Published: January 2023

AbstractThe oeuvre of the orientalist, Turkologist and traveler Ármin Vámbéry has been well researched, his long life full of adventures and his travels made him a famous personality on several continents during the Dualism-era, and so he has not succumbed to oblivion to this day. However, his creativity and work are multi-layered, so they require the approaches of various scientific disciplines, e.g. some facets of his widely ramified and not least unexplored journalistic work can be contributed to Vámbéry research. This article is devoted to Vámbéry's publication on the occasion of the Vienna World Exhibition of 1873, which also allow a comparison with the feuilletons of his friend, who later became a writer, cultural critic and Zionist, Max Nordau (1849, Pest–1923, Paris).
Quality of life of patients with paraurethral cysts
Authors: Mansur A. , Gritskievich A. A. , Kostin A. A. , Kulchenko N. G. , Pospelova O. M. , Kalinycheva G. E. 
Published: January 2023

Background. Paraurethral cyst (PC) is often found in women aged 20–60 years. The prevalence of PC in the female population is 1–6 %. Since PC are often located in the distal urethra and lie close to the genitals of a woman, the symptoms associated with this disease cause women both physical and psychological suffering.Aim. To assess the quality of life of women with PC.Materials and methods. The study included female individuals (n = 106) aged 18–60 years, in whom PC were detected during examination of the perineal region. The quality of life of the patients was assessed on the basis of the health quality questionnaire – SF-36.Results. The average volume of the PC in the observed women was 3.2 ± 1.3 cm. In the observed women, the intensity of pain in the perineum was directly proportional to the duration of the disease: up to a year – 86.3 ± 4.1; from one to three years – 76.4 ± 8.3; more than three years – 64.4 ± 9.2 (p <0.05). In this regard, in this category of patients, indicators of physical activity, psychological health and role functioning due to emotional state were reduced. Repeatedor constant pain during urination and during sexual activity causes severe distress, which affects the quality of life of patients with cystic formations in the paraurethral region.Conclusion. In women with PC on the background of dyspareunia up to 3 years and more, physical and psychological aspects of health suffer.
Análisis de los Modelos Organizacionales desde la Perspectiva de la Sociología de las Organizaciones en la Industria de la Construcción
Authors: Chávez Valencia Luis Elías , Martínez Molina Wilfrido , Tiburcio Sánchez María de Lourdes 
Published: January 2023

Alrededor del mundo, las expresiones de la cotidianidad llegan a ser contrastantes, a grados de mutualismo excluyente y radicalizados por la infodemia y el abuso del sentido común, que conducen a un pensamiento abigarrado y recalcitrante generalizado, mismo que promueve el individualismo, que a su vez es trasladado a las organizaciones contemporáneas, entre ellas las empresas de construcción. Para que el profesional pueda gestar los cambios en la empresa, y en el caso específico del frente de obra de la gerencia de residencia, es menester que reconozca los roles sociales de ese grupo, es decir, identificar el performance del profesionista, el capataz, el albañil y su ayudante, de tal forma que le permita proponer estructuras organizacionales tales como los comités ejecutivos plurales. Pero dicha intervención, puede darse siempre y cuando el frente de obra se comporte como una organización inteligente, la cual se entiende como un conglomerado que sobrepasa la productividad objetivo de la empresa, y que se da por medio de la comunicación simbólica, que logra que las cuadrillas puedan identificarse con la misión, visión y metas de la empresa, o con las estructuras normativas que promueven una cultura organizacional.
Propuesta de Innovación en Mercadotecnia para una Pequeña Empresa en la Industria del Vestido en Puebla
Authors: Ortíz Carranco Araceli , Ramírez Rosas José Gonzalo , Hernández Solís Rafael 
Published: January 2023

OBJETIVO: Proponer una innovación en mercadotecnia mediante un canal online, monitoreada con la Metodología del Cuadro de Mando Integral (CMI) en una Pyme poblana.
MATERIAL Y MÉTODO: Se analizó el desempeño del departamento de ventas de la Pyme y se elaboró la matriz de Fortalezas, Oportunidades, Debilidades y Amenazas (FODA); posteriormente, se realizó la Matriz Analítica de Definición de Estrategias (MAFE) para determinar la estrategia a seguir, así como el análisis del proceso de ventas, para proponer el nuevo canal de ventas online, optando por el social selling. Se hizo el análisis estadístico con el coeficiente R-cuadrado para determinar la correlación entre las variables objeto de estudio.
RESULTADOS: Se construyeron los indicadores para cada perspectiva del CMI, utilizando el software para monitoreo en tiempo real. Se logró la eliminación de los tiempos en el proceso de ventas, donde se cumplieron objetivos en el aumento de ventas de dicho departamento apoyándose del social selling de la Pyme.
CONCLUSIONES: La pyme estudiada innovó la Mercadotecnia, optando por el social selling para un mejor proceso, logrando aumentar su nivel de ventas, por lo que, el riesgo de quiebra se minimizó y se pudo comprobar el éxito de esta innovación.
Factors Associated with the Incidence of Stress Urinary Incontinence in Uterine Prolapse Cases at RSUD Dr. Soetomo Surabaya
Authors: Sari Romi Kiki Nur Fita , Kurniawati Eighty Mardiyan 
Published: January 2023

<div class="WordSection1"><p><strong>Background:</strong> Urinary incontinence (UI) is the involuntary leakage of urine, which can cause problems and have a negative impact on quality of life. Stress urinary incontinence is one of the subtypes of urinary incontinence which is defined as the involuntary expulsion of urine during exertion or physical activity, or sneezing, or coughing. The purpose of this study was to explain the relationship between age, type of delivery, parity, and body mass index with the incidence of stress urinary incontinence in cases of uterine prolapse at RSUD Dr Soetomo Surabaya.</p><p><strong>Method:</strong> This type of research is a quantitative research using analytical observational method, with a cross sectional approach. The sampling technique in this study was total sampling that met all inclusion and exclusion criteria. The independent variables of this study were age, type of delivery, parity, and body mass index. The dependent variable of this study is stress urinary incontinence.</p><p><strong>Result:</strong> Fisher's Exact test results on age, type of delivery, parity, and body mass index obtained p-values of 0.004, 0.021, 0.021, 0.014, 0,014 respectively. Because the p value of the five variables &gt; 0.05, it can be concluded that H1 is accepted.</p><p><strong>Conclusion: </strong>There is a relationship between age, type of delivery, parity, body mass index, and degree of uterine prolapse. The results of the logistic regression test showed that most related variable to the incidence of stress urinary incontinence was age.</p></div><div class="WordSection2"> </div><strong><br clear="all" /></strong>
Intervention for Reducing Maternal Mental Health Problems in The Golden Period: Systematic Review
Authors: Fatin Farisya Nurliana , Fitriana Farida , Hardianto Gatut 
Published: January 2023

<p><strong>Background: </strong>Data from World Health Organization informs that 10-16% of pregnant women and 13-20% of postpartum women have mental health problems worldwide. The most vulnerable time in this problem is when women experience it in the first 1000 days of life or the golden period. This issue has been untreated because of the gap between needs and service availability. This study aims to analyze the intervention for reducing maternal mental health problems during the golden period, especially can provide by the midwife as a health professional who is more accessible to the mother.</p><p><strong>Methods: </strong>Systematic review took articles from PubMed, Science Direct, Epistemonikos, and Google Scholar. Literature searching found 235 articles in 2021 that were analyzed using the PRISMA diagram.<strong></strong></p><p><strong>Result: </strong>Maternal mental health problem occurs due to the transition phase of the parent which is making a change of role and responsibility. It can provide negative effects on mother and child health. The articles have shown non-pharmacology interventions that have a different effect. Even, cognitive behavioral therapy shows a dominant effect in all studies that can use as single or combine therapy depending on the mother's condition. The midwife has also responsible to do early detection and should be taken training to facilitate this service for the mother.</p><p><strong>Conclusion: </strong>Maternal mental health during the golden period is crucial, especially for optimizing the child's development by the mother. Although the interventions have variated result, it is still beneficial for the mother.</p>
Analysis of Compliance Factors of Pregnant Mothers to Health Protocol Covid 19 when Containing Antenatal Care
Authors: Yunia Yusi Ratna , Dinengsih Sri , Novelia Shinta 
Published: January 2023

WHO recommends regular pregnancy checkups 8 meetings. However, with the current condition of the Covid-19 pandemic still not over, routine checks can be reduced in intensity to just 6 times. In several regions in Indonesia, such as in Yogyakarta, 6 pregnant women who tested positive for Covid 19 were found, in Surabaya there were 123 pregnant women who were positive for Covid-19, in Gresik there were 20 positive pregnant women for Covid-19 and in the Lampung region there were also three pregnant women who were positive Covid-19. With the increasing number of pregnant women who are positive for Covid 19, compliance with health protocols must be tightened in which pregnant women are people who are vulnerable to Covid 19 transmission. , and family support. The Objectives: know the analysis of the compliance factor of pregnant women with the Covid 19 health protocol during an ANC visit. Analytical research using cross-sectional method. The sample in this study amounted to 100 respondents. The sampling technique used total sampling. The research instrument was a questionnaire. Data were analyzed using univariate and bivariate with chi square statistical test. There was no significant relationship between age and education (p value> 0.05), while knowledge and family support showed a relationship with covid 19 health protocol compliance with p value <0.05. Compliance with the covid 19 health protocol in pregnant women is influenced by knowledge and family support. It is hoped that health workers should increase couns