bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ocean Heat Content Responses to Changing Anthropogenic Aerosol Forcing Strength: Regional and Multi‐Decadal Variability
Authors: Boland Emma J. D. , Dittus Andrea J. , Jones Daniel C. , Josey Simon A. , Sinha Bablu 
Published: June 2023

AbstractThe causes of decadal variations in global warming are poorly understood, however it is widely understood that variations in ocean heat content (OHC) are linked with variations in surface warming. To investigate the forced response of OHC to anthropogenic aerosols (AA), we use an ensemble of historical simulations, which were carried out using a range of anthropogenic aerosol forcing magnitudes in a CMIP6‐era global circulation model. We find that the centennial scale linear trends in historical OHC are significantly sensitive to AA forcing magnitude (−3.0 ± 0.1 × 105 (J m−3 century−1)/(W m−2), R2 = 0.99), but interannual to multi‐decadal variability in global OHC appear largely independent of AA forcing magnitude. Comparison with observations find consistencies in different depth ranges and at different time scales with all but the strongest aerosol forcing magnitude, at least partly due to limited observational accuracy. We find that OHC is sensitive to aerosol forcing magnitude across much of the tropics and sub‐tropics, and stronger negative forcing induces more ocean cooling. The polar regions and North Atlantic show the strongest heat content trends, and also show the strongest dependence on aerosol forcing magnitude. However, the OHC response to increasing aerosol forcing magnitude in the North Atlantic and Southern Ocean is either dominated by internal variability, or strongly state dependent, showing different behavior in different time periods. Our results suggest the response to aerosols in these regions is a complex combination of influences from ocean transport, atmospheric forcings, and sea ice.
Long‐Term Offshore Borehole Fluid‐Pressure Monitoring at the Northern Cascadia Subduction Zone and Inferences Regarding the State of Megathrust Locking
Authors: Davis Earl E. , Sun Tianhaozhe , Heesemann Martin , Becker Keir , Schlesinger Angela 
Published: June 2023

AbstractThe Cascadia subduction megathrust off the Pacific Northwest follows an “end member” seismogenic behavior, producing large (up to moment magnitude 9) but infrequent (every several hundred years) earthquakes and tsunamis. Crustal deformation associated with the ongoing plate convergence has been characterized by land‐based geodetic observations, but the state of locking across the full breadth of the seismogenic fault is poorly constrained. We report results of offshore monitoring of borehole fluid pressure, as a proxy for formation volumetric strain, at a site ∼20 km landward of the Cascadia subduction deformation front since 2010. The multi‐depth pressure records were plagued by hydrologic noise, but noise at the deepest monitoring level (303 m sub‐seafloor) abated in 2015. Subsequently, including at the times of regional large earthquakes that caused significant dynamic stressing, no persistent pressure transients are present above a threshold of 0.08 kPa imposed by unremovable oceanographic signals, corresponding to a strain detection limit of ∼16 nanostrain. Simple dislocation models using local megathrust geometry suggest a resolvable slip of <1 cm along a trench‐normal corridor beneath the borehole for a range of slip‐patch dimensions. A large slip patch can be well resolved even at considerable along‐strike distances from the borehole; for instance, ∼10 cm slip is detectable over a 200‐km strike range for a slip‐patch radius of ∼50 km. This high sensitivity for detecting slip, along with the lack of observed events, stands in stark contrast to observations at other subduction zones, and suggests that the Northern Cascadia megathrust is most likely fully locked.
Hybrid Simulation of Proton Cyclotron Waves Upstream of Mars Generated by Pickup Ion Beam Distribution
Authors: Cheng Kun , Liu Kaijun , Mousavi Ameneh , Cowee Misa , Liu Yuqi , Wang Yan , Wang Mengmeng , Zheng Xianming , Zhou Jingyi 
Published: June 2023

AbstractLinear instability analysis as well as a corresponding two‐dimensional hybrid simulation are performed to examine the excitation of the proton cyclotron waves observed upstream of Mars. The waves are believed to be excited by the pickup ions produced from the ionization of the Martian hydrogen exosphere. And previous statistical analysis of wave observations suggested that the waves are mostly related to pickup ion beam velocity distributions. While earlier linear instability analysis of pickup ion beam distributions has mainly been focused on the parallel unstable modes, our analysis reveals that the maximum growth rate occurs at very oblique propagation. The corresponding hybrid simulation confirms the linear analysis results and further demonstrates that the pickup ions are scattered toward an isotropic shell velocity distribution by the waves excited. Interestingly, the waves at oblique propagation gradually damp out and the system is eventually dominated by waves of quasi‐parallel propagation.
Dissecting the causal association between social or physical inactivity and depression: a bidirectional two-sample Mendelian Randomization study
Authors: Zhao Guorui , Lu Zhe , Sun Yaoyao , Kang Zhewei , Feng Xiaoyang , Liao Yundan , Sun Junyuan , Zhang Yuyanan , Huang Yu , Yue Weihua 
Published: June 2023

AbstractA growing body of research suggests that social or physical activity can affect the risk of Major depressive disorder (MDD). However, the bidirectional relationship between them remains to be clarified further, especially between inactivity and MDD. Here, we performed a two-sample Mendelian Randomization analysis using genetic variants associated with social/physical activities and MDD, and assessed the mediating effect of obesity-related measures and brain imaging phenotypes. The dataset on MDD, social activities, and physical activities included 500,199; 461,369; 460,376 individuals, respectively. Information regarding body mass index (BMI), body fat percentage (BFP), IDPs for 454,633; 461,460; 8,428 participants, respectively. We identified bidirectional causal relationships between sport clubs or gyms, strenuous sports, heavy do-it-youself, other exercises and MDD. We also observed that leisure/social inactivity (odds ratio [OR] = 1.64; P = 5.14 × 10−5) or physical inactivity (OR = 3.67; P = 1.99 × 10−5) caused an increased risk of MDD, which were partially mediated by BMI or BFP and masked by the weighted-mean orientation dispersion index of left acoustic radiation or volume of right caudate. Furthermore, we discovered that MDD increased the risk of leisure/social inactivity (OR = 1.03; P = 9.89 × 10−4) or physical inactivity (OR = 1.01; P = 7.96 × 10−4). In conclusions, we found that social/physical activities reduced the risk of MDD, while MDD in turn hindered social/physical activities. Inactivity may increase the risk of MDD, which was mediated or masked by brain imaging phenotypes. These results help to understand the manifestations of MDD and provide evidence and direction for the advancement of intervention and prevention.
The dental management of patients irradiated for head and neck cancer
Authors: Goh Elizabeth Z. , Beech Nicholas , Johnson Nigel R. , Batstone Martin 
Published: June 2023

AbstractPatients undergoing radiotherapy for head and neck cancers are prone to a range of dental complications, including mucositis, trismus, xerostomia, radiation caries and osteoradionecrosis. Specific considerations include the preventive, restorative and rehabilitative management of such patients, and the prevention and treatment of complications. This article aims to highlight the current understanding and management of dental needs for patients who have had or will undergo radiotherapy.
Targeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis
Authors: Hong Shiao-Ya , Lu Ya-Ting , Chen Shih-Yu , Hsu Chiung-Fang , Lu Yi-Chun , Wang Cheng-Yi , Huang Kun-Lun 
Published: June 2023

AbstractIdiopathic pulmonary fibrosis is a progressive fibrotic disorder with no cure that is characterized by deterioration of lung function. Current FDA-approved drugs for IPF delay the decline in lung function, but neither reverse fibrosis nor significantly improve overall survival. SHP-1 deficiency results in hyperactive alveolar macrophages accumulating in the lung, which contribute to the induction of pulmonary fibrosis. Herein, we investigated whether employing a SHP-1 agonist ameliorates pulmonary fibrosis in a bleomycin-induced pulmonary fibrosis murine model. Histological examination and micro-computed tomography images showed that SHP-1 agonist treatment alleviates bleomycin-induced pulmonary fibrosis. Reduced alveolar hemorrhage, lung inflammation, and collagen deposition, as well as enhanced alveolar space, lung capacity, and improved overall survival were observed in mice administered the SHP-1 agonist. The percentage of macrophages collected from bronchoalveolar lavage fluid and circulating monocytes in bleomycin-instilled mice were also significantly reduced by SHP-1 agonist treatment, suggesting that the SHP-1 agonist may alleviate pulmonary fibrosis by targeting macrophages and reshaping the immunofibrotic niche. In human monocyte-derived macrophages, SHP-1 agonist treatment downregulated CSF1R expression and inactivated STAT3/NFκB signaling, culminating in inhibited macrophage survival and perturbed macrophage polarization. The expression of pro-fibrotic markers (e.g., MRC1, CD200R1, and FN1) by IL4/IL13-induced M2 macrophages that rely on CSF1R signaling for their fate-determination was restricted by SHP-1 agonist treatment. While M2-derived medium promoted the expression of fibroblast-to-myofibroblast transition markers (e.g., ACTA2 and COL3A1), the application of SHP-1 agonist reversed the transition in a dose-dependent manner. Our report indicates that pharmacological activation of SHP-1 ameliorates pulmonary fibrosis via suppression of CSF1R signaling in macrophages, reduction of pathogenic macrophages, and the inhibition of fibroblast-to-myofibroblast transition. Our study thus identifies SHP-1 as a druggable target for the treatment of IPF, and suggests that the SHP-1 agonist may be developed as an anti-pulmonary fibrosis medication that both suppresses inflammation and restrains fibroblast-to-myofibroblast transition.
Data fusion and multivariate analysis for food authenticity analysis
Authors: Hong Yunhe , Birse Nicholas , Quinn Brian , Li Yicong , Jia Wenyang , McCarron Philip , Wu Di , da Silva Gonçalo Rosas , Vanhaecke Lynn , van Ruth Saskia , Elliott Christopher T. 
Published: June 2023

AbstractA mid-level data fusion coupled with multivariate analysis approach is applied to dual-platform mass spectrometry data sets using Rapid Evaporative Ionization Mass Spectrometry and Inductively Coupled Plasma Mass Spectrometry to determine the correct classification of salmon origin and production methods. Salmon (n = 522) from five different regions and two production methods are used in the study. The method achieves a cross-validation classification accuracy of 100% and all test samples (n = 17) have their origins correctly determined, which is not possible with single-platform methods. Eighteen robust lipid markers and nine elemental markers are found, which provide robust evidence of the provenance of the salmon. Thus, we demonstrate that our mid-level data fusion - multivariate analysis strategy greatly improves the ability to correctly identify the geographical origin and production method of salmon, and this innovative approach can be applied to many other food authenticity applications.
High-efficiency bio-inspired hybrid multi-generation photovoltaic leaf
Authors: Huang Gan , Xu Jingyuan , Markides Christos N. 
Published: June 2023

AbstractMost solar energy incident (>70%) upon commercial photovoltaic panels is dissipated as heat, increasing their operating temperature, and leading to significant deterioration in electrical performance. The solar utilisation efficiency of commercial photovoltaic panels is typically below 25%. Here, we demonstrate a hybrid multi-generation photovoltaic leaf concept that employs a biomimetic transpiration structure made of eco-friendly, low-cost and widely-available materials for effective passive thermal management and multi-generation. We demonstrate experimentally that bio-inspired transpiration can remove ~590 W/m2 of heat from a photovoltaic cell, reducing the cell temperature by ~26 °C under an irradiance of 1000 W/m2, and resulting in a relatively 13.6% increase in electrical efficiency. Furthermore, the photovoltaic leaf is capable of synergistically utilising the recovered heat to co-generate additional thermal energy and freshwater simultaneously within the same component, significantly elevating the overall solar utilisation efficiency from 13.2% to over 74.5%, along with over 1.1 L/h/m2 of clean water.
SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases
Authors: Gonnot Fabrice , Boulogne Laura , Brun Camille , Dia Maya , Gouriou Yves , Bidaux Gabriel , Chouabe Christophe , Crola Da Silva Claire , Ducreux Sylvie , Pillot Bruno , Kaczmarczyk Andrea , Leon Christelle , Chanon Stephanie , Perret Coralie , Sciandra Franck , Dargar Tanushri , Gache Vincent , Farhat Fadi , Sebbag Laurent , Bochaton Thomas , Thibault Helene , Ovize Michel , Paillard Melanie , Gomez Ludovic 
Published: June 2023

AbstractDespite advances in cardioprotection, new therapeutic strategies capable of preventing ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA2) phosphorylation at serine 663 is a clinical and pathophysiological event of cardiac function. Indeed, the phosphorylation level of SERCA2 at serine 663 is increased in ischemic hearts of patients and mouse. Analyses on different human cell lines indicate that preventing serine 663 phosphorylation significantly increases SERCA2 activity and protects against cell death, by counteracting cytosolic and mitochondrial Ca2+ overload. By identifying the phosphorylation level of SERCA2 at serine 663 as an essential regulator of SERCA2 activity, Ca2+ homeostasis and infarct size, these data contribute to a more comprehensive understanding of the excitation/contraction coupling of cardiomyocytes and establish the pathophysiological role and the therapeutic potential of SERCA2 modulation in acute myocardial infarction, based on the hotspot phosphorylation level of SERCA2 at serine 663 residue.
MG1 interacts with a protease inhibitor and confers resistance to rice root-knot nematode
Authors: Wang Xiaomin , Cheng Rui , Xu Daochao , Huang Renliang , Li Haoxing , Jin Liang , Wu Yufeng , Tang Jiuyou , Sun Changhui , Peng Deliang , Chu Chengcai , Guo Xiaoli 
Published: June 2023

AbstractThe rice root-knot nematode (Meloidogyne graminicola) is one of the most destructive pests threatening rice (Oryza sativa L.) production in Asia; however, no rice resistance genes have been cloned. Here, we demonstrate that M. GRAMINICOLA-RESISTANCE GENE 1 (MG1), an R gene highly expressed at the site of nematode invasion, determines resistance against the nematode in several rice varieties. Introgressing MG1 into susceptible varieties increases resistance comparable to resistant varieties, for which the leucine-rich repeat domain is critical for recognizing root-knot nematode invasion. We also report transcriptome and cytological changes that are correlated with a rapid and robust response during the incompatible interaction that occurs in resistant rice upon nematode invasion. Furthermore, we identified a putative protease inhibitor that directly interacts with MG1 during MG1-mediated resistance. Our findings provide insight into the molecular basis of nematode resistance as well as valuable resources for developing rice varieties with improved nematode resistance.
Origin of minicircular mitochondrial genomes in red algae
Authors: Lee Yongsung , Cho Chung Hyun , Noh Chanyoung , Yang Ji Hyun , Park Seung In , Lee Yu Min , West John A. , Bhattacharya Debashish , Jo Kyubong , Yoon Hwan Su 
Published: June 2023

AbstractEukaryotic organelle genomes are generally of conserved size and gene content within phylogenetic groups. However, significant variation in genome structure may occur. Here, we report that the Stylonematophyceae red algae contain multipartite circular mitochondrial genomes (i.e., minicircles) which encode one or two genes bounded by a specific cassette and a conserved constant region. These minicircles are visualized using fluorescence microscope and scanning electron microscope, proving the circularity. Mitochondrial gene sets are reduced in these highly divergent mitogenomes. Newly generated chromosome-level nuclear genome assembly of Rhodosorus marinus reveals that most mitochondrial ribosomal subunit genes are transferred to the nuclear genome. Hetero-concatemers that resulted from recombination between minicircles and unique gene inventory that is responsible for mitochondrial genome stability may explain how the transition from typical mitochondrial genome to minicircles occurs. Our results offer inspiration on minicircular organelle genome formation and highlight an extreme case of mitochondrial gene inventory reduction.
Single-electron charge transfer into putative Majorana and trivial modes in individual vortices
Authors: Ge Jian-Feng , Bastiaans Koen M. , Chatzopoulos Damianos , Cho Doohee , Tromp Willem O. , Benschop Tjerk , Niu Jiasen , Gu Genda , Allan Milan P. 
Published: June 2023

AbstractMajorana bound states are putative collective excitations in solids that exhibit the self-conjugate property of Majorana fermions—they are their own antiparticles. In iron-based superconductors, zero-energy states in vortices have been reported as potential Majorana bound states, but the evidence remains controversial. Here, we use scanning tunneling noise spectroscopy to study the tunneling process into vortex bound states in the conventional superconductor NbSe2, and in the putative Majorana platform FeTe0.55Se0.45. We find that tunneling into vortex bound states in both cases exhibits charge transfer of a single electron charge. Our data for the zero-energy bound states in FeTe0.55Se0.45 exclude the possibility of Yu–Shiba–Rusinov states and are consistent with both Majorana bound states and trivial vortex bound states. Our results open an avenue for investigating the exotic states in vortex cores and for future Majorana devices, although further theoretical investigations involving charge dynamics and superconducting tips are necessary.
Tumour mutations in long noncoding RNAs enhance cell fitness
Authors: Esposito Roberta , Lanzós Andrés , Uroda Tina , Ramnarayanan Sunandini , Büchi Isabel , Polidori Taisia , Guillen-Ramirez Hugo , Mihaljevic Ante , Merlin Bernard Mefi , Mela Lia , Zoni Eugenio , Hovhannisyan Lusine , McCluggage Finn , Medo Matúš , Basile Giulia , Meise Dominik F. , Zwyssig Sandra , Wenger Corina , Schwarz Kyriakos , Vancura Adrienne , Bosch-Guiteras Núria , Andrades Álvaro , Tham Ai Ming , Roemmele Michaela , Medina Pedro P. , Ochsenbein Adrian F. , Riether Carsten , Kruithof-de Julio Marianna , Zimmer Yitzhak , Medová Michaela , Stroka Deborah , Fox Archa , Johnson Rory 
Published: June 2023

AbstractLong noncoding RNAs (lncRNAs) are linked to cancer via pathogenic changes in their expression levels. Yet, it remains unclear whether lncRNAs can also impact tumour cell fitness via function-altering somatic “driver” mutations. To search for such driver-lncRNAs, we here perform a genome-wide analysis of fitness-altering single nucleotide variants (SNVs) across a cohort of 2583 primary and 3527 metastatic tumours. The resulting 54 mutated and positively-selected lncRNAs are significantly enriched for previously-reported cancer genes and a range of clinical and genomic features. A number of these lncRNAs promote tumour cell proliferation when overexpressed in in vitro models. Our results also highlight a dense SNV hotspot in the widely-studied NEAT1 oncogene. To directly evaluate the functional significance of NEAT1 SNVs, we use in cellulo mutagenesis to introduce tumour-like mutations in the gene and observe a significant and reproducible increase in cell fitness, both in vitro and in a mouse model. Mechanistic studies reveal that SNVs remodel the NEAT1 ribonucleoprotein and boost subnuclear paraspeckles. In summary, this work demonstrates the utility of driver analysis for mapping cancer-promoting lncRNAs, and provides experimental evidence that somatic mutations can act through lncRNAs to enhance pathological cancer cell fitness.
A multicentre study on grey matter morphometric biomarkers for classifying early schizophrenia and parkinson’s disease psychosis
Authors: Knolle Franziska , Arumugham Shyam S. , Barker Roger A. , Chee Michael W. L. , Justicia Azucena , Kamble Nitish , Lee Jimmy , Liu Siwei , Lenka Abhishek , Lewis Simon J. G. , Murray Graham K. , Pal Pramod Kumar , Saini Jitender , Szeto Jennifer , Yadav Ravi , Zhou Juan H. , Koch Kathrin 
Published: June 2023

AbstractPsychotic symptoms occur in a majority of schizophrenia patients and in ~50% of all Parkinson’s disease (PD) patients. Altered grey matter (GM) structure within several brain areas and networks may contribute to their pathogenesis. Little is known, however, about transdiagnostic similarities when psychotic symptoms occur in different disorders, such as in schizophrenia and PD. The present study investigated a large, multicenter sample containing 722 participants: 146 patients with first episode psychosis, FEP; 106 individuals in at-risk mental state for developing psychosis, ARMS; 145 healthy controls matching FEP and ARMS, Con-Psy; 92 PD patients with psychotic symptoms, PDP; 145 PD patients without psychotic symptoms, PDN; 88 healthy controls matching PDN and PDP, Con-PD. We applied source-based morphometry in association with receiver operating curves (ROC) analyses to identify common GM structural covariance networks (SCN) and investigated their accuracy in identifying the different patient groups. We assessed group-specific homogeneity and variability across the different networks and potential associations with clinical symptoms. SCN-extracted GM values differed significantly between FEP and Con-Psy, PDP and Con-PD, PDN and Con-PD, as well as PDN and PDP, indicating significant overall grey matter reductions in PD and early schizophrenia. ROC analyses showed that SCN-based classification algorithms allow good classification (AUC ~0.80) of FEP and Con-Psy, and fair performance (AUC ~0.72) when differentiating PDP from Con-PD. Importantly, the best performance was found in partly the same networks, including the thalamus. Alterations within selected SCNs may be related to the presence of psychotic symptoms in both early schizophrenia and PD psychosis, indicating some commonality of underlying mechanisms. Furthermore, results provide evidence that GM volume within specific SCNs may serve as a biomarker for identifying FEP and PDP.