bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Repairable Ionic Skin Based on Multiple Dynamic Bonds with Self‐Adhesive, Anti‐Freezing, and Antimicrobial Capabilities for Monitoring Human Motions
Authors: He Xiaoling , Yang Yuqing , Fan Jingying , Bai Xinyuan , Lu Hexuan , Wei Dongsheng 
Published: August 2023

AbstractBiomimetic ionic skins (i‐skins) have received intensive attention because of their capabilities to emulate various functions of human skin. However, challenges still remain in developing i‐skins with synergistic characteristics such as excellent mechanical properties, high strain sensitivity, freezing tolerance, and antimicrobial activity by a simple method. Herein, a hydrogel‐based i‐skin (P(AAc‐co‐CA)x) is facilely synthesized by one‐pot free radical copolymerization of vinyl choline‐asparagine ionic liquid (Cho‐Asn VIL) and acrylic acid (AAc) monomers using Al3+ as a crosslinker and bacterial cellulose (BC) as reinforcing agent, respectively. The resultant hydrogels integrate multiple excellent performances, including skin‐like modulus (100–300 KPa), superstretchability (2345 ± 97%), high self‐healing efficiency (93.7 ± 4.6%), recovery ratio (139.3 ± 7%) and conductivity (1.28 ± 0.06 S m−1), as well as transparency, self‐adhesiveness, antimicrobial activities, and biocompatible properties. Moreover, the i‐skins based on P(AAc‐co‐CA) x hydrogels exhibit high sensitivity (gauge factor (GF) of 2.77), rapid response time (300 ± 15 ms), and excellent durability to both tensile and compressive deformation, and thus can be used to monitor and distinguish human motions. Significantly, P(AAc‐co‐CA) x hydrogels can still maintain notable mechanical property, conductivity, and sensibility even at −20 °C. These integrated multiple advantages make P(AAc‐co‐CA) x hydrogels highly promising in the fields of i‐skins, flexible wearable sensors, and artificial intelligence.
Synthesis of Benzo[a]fluorene, Benzo[c]fluorene, and Benzo[j]fluoranthene via a Lewis Acid‐Catalyzed Prins‐Type Cycloaromatization: Application to the Total Synthesis of Viridistratin A
Authors: Jeong Myeonggyo , Yoon Moonsang , Nguyen Long Huu , Kim Soyeong , Han Jinhee , Tran Cong So , Kim Jisu , Jo Jeyun , Jung Young‐Suk , Yoo Jin‐Wook , Yun Hwayoung 
Published: August 2023

AbstractSynthesis of benzo[a]fluorene, benzo[c]fluorene, and benzo[j]fluoranthene have been accomplished from readily accessible enol ether precursors via a Lewis acid‐catalyzed Prins‐type cycloaromatization. Mechanistically, it was proposed that Lewis acids catalyze the generation of oxonium species, which accelerate subsequent annulation and aromatization. This protocol offers the benefit of an operationally simple, transition‐metal‐free, and air‐tolerant reaction condition, enabling gram‐scale syntheses of the desired products. The total synthesis of viridistratin A further supported this synthetic strategy for establishing polycyclic aromatic hydrocarbon architectures.
Decarbonization of the Electric Power Sector and Implications for Low‐Cost Hydrogen Production from Water Electrolysis
Authors: Badgett Alex , Brauch Joe , Saha Prantik , Pivovar Bryan 
Published: August 2023

AbstractIncreasing development of wind and solar generation in the power sector can create economic opportunities for the deployment of water electrolyzers that produce hydrogen. Temporal variation in the marginal cost of energy in future decarbonized grids can make it favorable for electrolyzers to dispatchably ramp hydrogen production up and down in response to low‐ and high‐cost times. Using this strategy, low‐cost hydrogen production is enabled by electrolyzers that are low‐capital cost and tolerant to frequent on/off cycling. Ramping down hydrogen production to a designated turndown ratio can avoid performance degradation caused by on/off cycling by not shutting the electrolyzer completely off. This comes with a slight cost penalty which can be minimized if the turndown ratio is low (i.e., the system ramps down hydrogen production to close to zero). These results suggest that electrolyzers integrated into future power systems are likely to benefit from the ability to ramp operation up and down quickly and operate in a standby mode. This analysis forms a basis for comparative tradeoffs between electrolyzer capital cost, operating strategy, and system durability and demonstrates the importance of considering all three factors in technoeconomic analysis.
Recent Progress on the Low‐Temperature Lithium Metal Batteries and Electrolytes
Authors: Huang Yiyu , Li Hongyan , Sheng Ouwei , Tao Xinyong , Jin Chengbin 
Published: August 2023

AbstractThe emergence and development of lithium (Li) metal batteries shed light on satisfying the human desire for high‐energy density beyond 400 Wh kg−1. Great efforts are devoted to improving the safety and cyclability of such new‐type batteries, and certain progress is successfully achieved. However, given the diversity of application scenarios, the practical applications of Li metal batteries still remain challenges, especially in extremely low temperatures. The drop in temperature largely reduces the capacity and lifespan of batteries due to sluggish Li‐ion (Li+) transportation and uncontrollable Li plating behaviors. Recently, attention is gradually paid to Li metal batteries for low‐temperature operation, where the explorations on high‐performance low‐temperature electrolytes emerge as a hot topic. In this review, the progress of low‐temperature Li metal batteries is systematically summarized. The challenges and influences of low temperatures on Li metal batteries are concluded. Subsequently, the solutions to low‐temperature Li metal batteries based on electrolyte engineering are reviewed and discussed. Additionally, the techniques for low‐temperature characterizations are classified and discussed. Most importantly, the future development prospects of low‐temperature Li metal batteries are proposed from sustainable perspectives.
A Multifunctional Interlocked Binder with Synergistic In Situ Covalent and Hydrogen Bonding for High‐Performance Si Anode in Li‐ion Batteries
Authors: Hwang Jae Hyuk , Kim Eunji , Lim Eun Young , Lee Woohwa , Kim Ji‐Oh , Choi Inhye , Kim Yong Seok , Kim Dong‐Gyun , Lee Jin Hong , Lee Jong‐Chan 
Published: August 2023

AbstractSilicon has garnered significant attention as a promising anode material for high‐energy density Li‐ion batteries. However, Si can be easily pulverized during cycling, which results in the loss of electrical contact and ultimately shortens battery lifetime. Therefore, the Si anode binder is developed to dissipate the enormous mechanical stress of the Si anode with enhanced mechanical properties. However, the interfacial stability between the Si anode binder and Cu current collector should also be improved. Here, a multifunctional thiourea polymer network (TUPN) is proposed as the Si anode binder. The TUPN binder provides the structural integrity of the Si anode with excellent tensile strength and resilience due to the epoxy‐amine and silanol‐epoxy covalent cross‐linking, while exhibiting high extensibility from the random coil chains with the hydrogen bonds of thiourea, oligoether, and isocyanurate moieties. Furthermore, the robust TUPN binder enhances the interfacial stability between the Si anode and current collector by forming a physical interaction. Finally, the facilitated Li‐ion transport and improved electrolyte wettability are realized due to the polar oligoether, thiourea, and isocyanurate moieties, respectively. The concept of this work is to highlight providing directions for the design of polymer binders for next‐generation batteries.
TRIM21‐Promoted FSP1 Plasma Membrane Translocation Confers Ferroptosis Resistance in Human Cancers
Authors: Gong Jun , Liu Yuhui , Wang Wenjia , He Ruizhi , Xia Qilong , Chen Lin , Zhao Chunle , Gao Yang , Shi Yongkang , Bai Yu , Liao Yangwei , Zhang Qi , Zhu Feng , Wang Min , Li Xu , Qin Renyi 
Published: August 2023

AbstractFerroptosis, an iron‐dependent form of regulated cell death driven by excessive accumulation of lipid peroxides, has become a promising strategy in cancer treatment. Cancer cells exploit antioxidant proteins, including Ferroptosis Suppressor Protein 1 (FSP1), to prevent ferroptosis. In this study, it is found that the E3 ubiquitin ligase TRIM21 bound to FSP1 and mediated its ubiquitination on K322 and K366 residues via K63 linkage, which is essential for its membrane translocation and ferroptosis suppression ability. It is further verified the protective role of the TRIM21‐FSP1 axis in RSL3‐induced ferroptosis in cancer cells and a subcutaneous tumor model. Moreover, TRIM21 is highly expressed in multiple gastrointestinal (GI) tumors, and its expression is further stimulated upon ferroptosis induction in cancer cells and the KPC mouse model. In summary, This study identifies TRIM21 as a negative regulator of ferroptosis through K63 ubiquitination of FSP1, which can serve as a therapeutic target to enhance the chemosensitivity of tumors based on ferroptosis induction.
A Mycovirus VIGS Vector Confers Hypovirulence to a Plant Pathogenic Fungus to Control Wheat FHB
Authors: Zhang Lihang , Wang Shuangchao , Ruan Shaojian , Nzabanita Clement , Wang Yanfei , Guo Lihua 
Published: August 2023

AbstractMycovirus‐mediated hypovirulence has the potential to control fungal diseases. However, the availability of hypovirulence‐conferring mycoviruses for plant fungal disease control is limited as most fungal viruses are asymptomatic. In this study, the virus‐induced gene silencing (VIGS) vector p26‐D4 of Fusarium graminearum gemytripvirus 1 (FgGMTV1), a tripartite circular single‐stranded DNA mycovirus, is successfully constructed to convert the causal fungus of cereal Fusarium head blight (FHB) into a hypovirulent strain. p26‐D4, with an insert of a 75–150 bp fragment of the target reporter transgene transcript in both sense and antisense orientations, efficiently triggered gene silencing in Fusarium graminearum. Notably, the two hypovirulent strains, p26‐D4‐Tri101, and p26‐D4‐FgPP1, obtained by silencing the virulence‐related genes Tri101 and FgPP1 with p26‐D4, can be used as biocontrol agents to protect wheat from a fungal disease FHB and mycotoxin contamination at the field level. This study not only describes the first mycovirus‐derived VIGS system but also proves that the VIGS vector can be used to establish multiple hypovirulent strains to control pathogenic fungi.
Anti‐PD‐1/Her2 Bispecific Antibody IBI315 Enhances the Treatment Effect of Her2‐Positive Gastric Cancer through Gasdermin B‐Cleavage Induced Pyroptosis
Authors: Lin Wu , Zhang Yingzi , Yang Yan , Lin Ben , Zhu Mengjia , Xu Jinling , Chen YiRan , Wu Weiwei , Chen Bingliang , Chen Xiangliu , Liu Jin , Wang Haohao , Teng Fei , Yu Xiongfei , Wang Haiyong , Lu Jun , Zhou Quan , Teng Lisong 
Published: August 2023

AbstractThe majority of patients with human epidermal growth factor receptor 2 (Her2)‐positive gastric cancer develop refractory to Her2‐targeted therapy, where upregulation of immune checkpoints plays an essential role. Herein, a recombinant fully human IgG1 bispecific antibody IBI315 targeting both PD‐1 and Her2 is developed and its antitumor efficacy as well as the underlying mechanism is investigated. IBI315 crosslinks the physical interaction between Her2‐positive tumor cells and PD‐1‐positive T cells, resulting in significantly enhanced antitumor effects compared to each parent antibody or their combination, both in vitro and in vivo mouse tumor models reconstituted with human immune cells using patient‐derived xenografts and organoids. Moreover, IBI315 treatment also induces the recruitment and activation of immune cells in tumors. Mechanistically, IBI315 triggers gasdermin B (GSDMB)‐mediated pyroptosis in tumor cells, leading to the activation and recruiments of T cells. The activated T cells secret IFNγ, enhancing GSDMB expression and establishing a positive feedback loop of T cell activation and tumor cell killing. Notably, GSDMB is found to be elevated in Her2‐positive gastric cancer cells, providing a rationale for IBI315's efficacy. IBI315 is supported here as a promising bispecific antibody‐based immunotherapy approach for Her2‐positive gastric cancer in preclinical studies, broadening the therapeutic landscape of this patient population.
Highly Stretchable Conductor Inspired by Compliant Mechanism
Authors: Lu Zhilai , Deng Yinjun , Zhou Xintong , He Lei , Song Jianan , Wang Qingshan , Xia Jianfang , Liu Linpeng , Hammad Farid A. , Tian Yanling 
Published: August 2023

AbstractFlexible and stretchable conductors have invaluable applications in multiple domains, such as sensors, displays, and electronic skins. The stable conductance exhibited by conductors when subjected to diverse forms of deformation, such as tensile stress, curvature, or torsion, represents a fundamental characteristic. Attaining high conductivity and stretchability simultaneously in conductive materials is a formidable challenge, owing to inherent constraints in materials found in nature. To overcome this problem, an innovative approach of structurally designing conductors using existing materials to achieve high deformability and stretchability, i.e. stretchable conductors inspired by a compliant mechanism is proposed in this paper. Thus, a novel stretchable conductor inspired by flexible mechanisms is introduced. Unlike stretchable conductors based on Kirigami structures, the stretchable conductor based on flexible mechanisms can achieve large in‐plane deformation within the material's strength limit. The concept and design process of the highly deformable stretchable conductor inspired by flexible mechanisms are presented in this paper. Experimental results show that the resistance change ratio of the conductor remains within 0.05% during the 0–200% strain process. The consistency and durability of the conductor during stretching deformation are also confirmed through 500 repetitions of the test. Additionally, the experiments with the electric motor and light‐emitting diode (LED) light confirm the conductor's ability to maintain a stable current.
Carbon‐Binder Design for Robust Electrode–Electrolyte Interfaces to Enable High‐Performance Microsized‐Silicon Anode for Batteries
Authors: Wang Fei , Wang Yuchen , Liu Zhendong , Zhang Chengzhi , Li Linqing , Ye Chong , Liu Jinshui , Tan Jun 
Published: August 2023

AbstractMicrosized‐silicon (µ‐Si, >1 µm) is one of the ideal anodes for lithium‐ion batteries due to its low‐cost, high tap density, and high specific capacity. However, during repeated lithiation/delithiation processes, µ‐Si undergoes huge volume changes. This leads to continued capacity loss during cycling due to severe particle pulverization, separation from the conductive network and uncontrolled growth of an unstable solid‐electrolyte interphase (SEI). Herein, an electrode construction strategy is proposed by carbonization of the slurry‐casting µ‐Si electrode. The organic binder serves as both carbon resource and physical framework, which is carbonized to form a carbon binder that is chemically bonded with the µ‐Si particles and within the electrode. The electrode with carbon binder ensures stable electric channel and promotes formation of a stable and passivating SEI at the interface with a high µ‐Si content up to 82 wt%. The carbon binder offers physical buffer that shield against localized strain and modifies the surface reactivity, which enables a high initial Coulombic efficiency (91.85%) and stable cycle performance at commercial‐level areal capacities (2 mAh cm−2). This work offers an easily scalable yet practical approach for the current battery industry without any electrolyte modification or complicated manufacturing methods.
Gradient Concentration Refilling of N Stabilizes Oxygen Vacancies for Enhanced Zn2+ Storage
Authors: Wang Ming , Zhao Guangyu , Bai Xiaoming , Yu Weijian , Zhao Chenghao , Gao Zhenren , Lyu Pengbo , Chen Zhaoyu , Zhang Naiqing 
Published: August 2023

AbstractThe introduction of oxygen vacancies into aqueous zinc ion battery (ZIB) cathodes can significantly improve the diffusion kinetics of Zn2+, endowing enhanced electrochemical performance. However, the stability of oxygen vacancies in batteries during aqueous electrolyte cycling has been overlooked. Here, the oxygen vacancy is stabilized by the refilling of different impurity atoms, and gradient concentration refilling of N achieves the most stable state of the oxygen vacancy with minimum formation energy (4.77 eV). The obtained Zn3V2O7(OH)2·2H2O with gradient N refilling of partial oxygen vacancies (N‐VO‐ZVO) achieves more stable oxygen vacancies and a low Zn2+ diffusion energy barrier (0.19 eV) with an ultra‐high rate performance of 186 mAh g−1 at 100 A g−1 and capacity retention rate of 84.9% after 10 000 cycles.
An insight into sainfoin (Onobrychis viciifolia Scop.) breeding: Challenges and achievements
Authors: Poudel Hari P. , Bhattarai Surendra , Singer Stacy D. , Biligetu Bill , Acharya Surya 
Published: August 2023

AbstractOver the last decade, there has been a renewed interest in sainfoin (Onobrychis viciifolia Scop.), particularly among western Canadian forage and beef‐cattle producers. A major trigger has been the availability of new sainfoin cultivars with improved compatibility with alfalfa (Medicago sativa). These new cultivars in binary mixture with alfalfa significantly reduced the incidence of alfalfa pasture bloat in grazing animals, potentially saving an estimated CAD 300–500 million worldwide, largely by eliminating direct animal losses and expenses associated with prevention and treatment. Although the development of new sainfoin cultivars was a significant breakthrough, this alone did not ensure its adoption by producers in western Canada. Indeed, concerns and questions endured, including whether sainfoin cultivars could in fact grow together with alfalfa and persist as a perennial crop, whether including sainfoin in alfalfa stands would make the pasture bloat safe, whether the biomass yield of sainfoin was comparable to that of alfalfa for a profitable return, and whether livestock would graze sainfoin to the same extent as alfalfa. In this review study, we provide an overview of sainfoin breeding research and discuss how new sainfoin cultivars (AAC‐Mountainview and AAC‐Glenview) were developed in Canada for binary mixtures with alfalfa. Additionally, we highlight current progress in sainfoin breeding efforts and the prospect of this species as a livestock feed for a sustainable agriculture system.
Impact of biological seed treatments on maize (Zea mays L.) and soil: Crop growth and yield
Authors: Cano Camacho Valeria , Potter Stephen W. , McDaniel Marshall D. , Licht Mark A. 
Published: August 2023

AbstractSeed treatments have been used since the 17th century, but interest has accelerated in the last 20 years due to our increased understanding and importance of the plant microbiome. Particularly, biological seed treatments (BST) have rapidly gained popularity because soil biota is critical to plant health. Despite growing interest and an expanding market, we still lack understanding of what conditions BST are most effective for plant health. The objective of this study was to understand if seed treatments (including BST) will increase maize (Zea mays L.) growth and grain yield. Here, we tested (1) four maize hybrids and (2) five seed treatments (untreated control [UTC], base fungicide control [BFC], BFC + Poncho [P5] [Clothianidin], BFC + Poncho Votivo [P5V] [Bacillus firmus I‐1582], BFC + Poncho Votivo + TWO.O [P5V2] [Bacillus firmus I‐1582 plus Bacillus thuringiensis EX297512]) across four site‐years. Both BFC and BST had little effect on normalized difference vegetation index (NDVI), plant height, and lodging. We did find a variable effect of BST on maize yield, with a significant site‐year × hybrid interaction (p = 0.06). For instance, in 2019 in Northwest Iowa, both BST treatments (P5V and P5V2) increased yield by an average of 1.5 Mg ha−1 compared to the control (+12%, p < 0.032). BST can improve maize yields, but complex hybrid‐BST interactions warrant further understanding in order to maximize the benefit of BST.
Novel amino acid ionic liquids prepared via one‐step lactam hydrolysis for the highly efficient capture of CO2
Authors: Wen Shuyue , Wang Tao , Zhang Xiaomin , Xu Weigao , Hu Xingbang , Wu Youting 
Published: August 2023

AbstractThis article proposes for the first time the preparation of a series of amino acid ionic liquids (AAILs) via one‐step hydrolysis of cheap lactams for the capture of CO2. The structures of the prepared AAILs are confirmed using NMR, FTIR, and ESI‐MS, and their physical properties are also determined. It is found that these AAILs are reversible CO2 absorbents with very high absorption capacities (0.15 to 0.18 g·g−1 at 313.2 K and 1.0 bar), better than almost all task‐specific ionic liquids reported in literatures. The absorption mechanism is also elucidated to be a combination of 1:1 and 2:1 stoichiometric reaction of AAILs with CO2 from NMR, FTIR, reaction equilibrium thermodynamical modeling and quantum calculations. The AAILs have the advantages of simple synthesis, high yield, and using available cheap raw materials. It is believed that this kind of AAILs have great potentials to be used as efficient CO2 absorbents.
A homozygous missense variant in the PLCB4 gene causes severe phenotype of auriculocondylar syndrome type 2
Authors: El Fizazi Khawla , Bouramtane Abdelhamid , Abbassi Meriame , El Asri Yasser Ali , Askander Omar , El Fahime Mustapha , Ouldim Karim , Ridal Mohammed , Bouguenouch Laila 
Published: August 2023

AbstractAuriculocondylar syndrome (ARCND) is a rare craniofacial birth defect characterized by malformations in the mandible and external ear (Question Mark Ear). Genetically, three distinct subtypes of ARCND (ARCND1, ARCND2, and ARCND3) have been identified. ARCND2 is linked to pathogenic variants in the PLCB4 gene (phospholipase C β4). PLCB4 is a key effector of the EDN1‐EDNRA pathway involved in craniofacial development via the induction, migration, and maintenance of neural crest cells. ARCND2 is typically inherited in an autosomal dominant pattern, with recessive inheritance pattern being rare. In this study, we report the first homozygous missense variant (NM_000933.4: c.2050G>A: p.(Gly684Arg)) in the PLCB4 gene causing ARCND in a 3‐year‐old patient with a severe clinical phenotype of the syndrome. The patient presented with typical craniofacial ARCND features, in addition to intestinal transit defect, macropenis, and hearing loss. These findings further delineate the phenotypic spectrum of ARCND associated with autosomal recessive PLCB4 loss of function variants. Notably, our results provide further evidence that these variants can result in a more severe and diverse manifestations of the syndrome. Clinicians should consider the rare features of this condition for better management of patients.
TfOH‐Catalyzed Highly Regioselective Synthesis of Conjugated Enones by Coupling of Alkynes and Aldehydes
Authors: Sudheer Mokhamatam , Rao Chinthu Joginarayana , Battula Venkateswara Rao 
Published: August 2023

AbstractTriflic acid‐catalyzed regioselective enone synthesis from intermolecular coupling of aldehydes and alkynes has been developed. The present reaction is very efficient, effective, simple in nature and mild. The substrate scope is very diverse. This metathesis reaction exclusively provided trans product using aryl and aliphatic aldehydes and internal and terminal alkynes.