bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONSERVATIVE MANAGEMENT PELVIC FRACTURE URETHRAL INJURY (PFUI) IN A GIRL: A CASE REPORT
Authors: Sulistyanti Rachma Fitri , Satyagraha Paksi , Nurhadi Pradana , Daryanto Besut 
Published: September 2023

ABSTRACT
Objective: This case report aims to describe a different approach of PFUI by conservative management that resulted in good outcome. Case(s) Presentation: A 7-year-old girl patient was brought to the emergency department after falling from public transportation diagnosed with suspicious urethral rupture, perineal rupture grade III, vertical-shear type pelvic-ring injury, laceration wound on the right lower leg, abrasion on the medial side left lower leg and urinary retention. The patient underwent percutaneous cystostomy, pelvic bandage, a perineal debridement and repair, a cystography, percutaneous vesicolithotripsy, cystostomy and synechiae incision. One year after the first admission it was planned for urethroplasty due to completely obliterated from antegrade and retrograde panendoscopy. Discussion: 8 months later urethroplasty was aborted because of an open bladder neck, a fistula at the anterior connected to the distal of the bladder neck with size of 3 mm. The patient was performed a silicon cystostomy catheter insertion for 6 weeks. At the time of evaluation, the fistula was closed, it was proven by Qmax uroflowmetry was 18ml/s with average flow: 9.8 ml/s, voiding volume: 90ml, flow time: 9s, voiding time: 9s, hesistance:1.5, and PVR:5.35 cc. Conclusion: In this case, it showed that conservative management could improve PFUI with satisfactory result, proved by good result of uroflowmetry. However, periodic evaluations must be carried out to follow the progress of the disease and the possibility of future complications including sexual function.
Keywords: PFUI, girl, urethral rupture
Gambaran Tingkat Pengetahuan Ibu Tentang Penggunaan Obat Cacing Pada Anak
Authors: Kurniasih Dea Anita Ariani , Kurniasari Icha Putri Ayu , Gianti Lisna 
Published: September 2023

Latar belakang : Cacingan merupakan penyakit yang disebabkan oleh parasit usus yang tersebar meluas di Indonesia. Cacingan dikatakan jarang menyebabkan kematian, namun dapat mempengaruhi kesehatan dan produktivitas penderitanya dengan menurunkan status gizi. Efeknya lambat dan biasanya tanpa gejala, itulah sebabnya penyakit ini diabaikan di antara penyakit lainnya. Risiko ini semakin diperumit oleh fakta bahwa anak-anak dan orang tua/wali, terutama ibu, tidak mengetahui pencegahan cacingan. Menciptakan kesadaran di antara anak-anak dan orang tua dapat membantu melawan penyakit ini. Tujuan: Mengetahui gambaran tingkat pengetahuan ibu mengenai penggunaan obat cacing pada anak. Metode: Studi deskriptif kuantitatif metode survei potong lintang (cross sectional) dengan menggunakan kuesioner lewat google form dengan cara pengambilan sampel seluruhnya (total sampling), melibatkan 52 responden di salah satu Posyandu Kota Bandung. Hasil: Tingkat pengetahuan Ibu terhadap penggunaan obat cacing sebesar 59,6% memiliki tingkat pengetahuan baik, 34,6% memiliki tingkat pengetahuan cukup, dan 5,8% memiliki tingkat pengetahuan kurang. Simpulan dan saran: Penyakit cacingan pada anak dipengaruhi oleh tingkat pengetahuan ibu. Diperlukan konsumsi obat cacing secara teratur dan melakukan pemeriksaan kesehatan secara berkala dan edukasi kesehatan diberikan bagi ibu yang datang ke Posyandu.
Tingkat Kepuasan Konsumen terhadap Kualitas Pelayanan Obat Tanpa Resep di Apotek Nakula Tasikmalaya
Authors: Ririn Siti Nurapriani  , Eddy Suhardiana  , Kamiel Roesman Bachtiar  
Published: September 2023

Latar Belakang Telah dilakukan penelitian terhadap Apotek Nakula dengan melihat tingkat kepuasan konsumen Swamedikasi berdasarkan lima parameter yaitu tangible (bukti fisik), emphaty (empati), realibility (kehandalan), responsiveness (ketanggapan), dan assurance (jaminan). Tujuan dari penelitian ini yaitu untuk mengetahui tingkat kepuasan konsumen terhadap pelayanan obat tanpa resep dan tingkat kepuasan konsumen terhadap pelayanan obat tanpa resep berdasarkan tangible, emphaty, responsivene, reability dan assurance. Metode penelitian secara deskriptif dengan mmeberikan kuisioner pada konsumen untuk menilai tingkat kepuasan berdasarkan skala likert. Hasil penelitian berdasarkan kuisioner yang disampaikan diperoleh nilai kualitas pelayanan untuk dimensi tangible -0,57%, emphaty -0,80%, realibility -0,79%, responsitiveness -0,85% serta assurance -0,77% dan nilai kualitas secara keseluruhan adalah -0,70%. Maka kesimpulannya nilai kualitas pelayanan obat tanpa resep di Apotek Nakula konsumen belum puas
Perancangan dan Pembuatan Prototipe Motor Listrik BLDC 350 dan 3000 Watt
Authors: Muslimin Muslimin , Dhyani Putri Paramita , Luqyana Dhiya , Kristianto Daniel Janthinus Kristianto 
Published: September 2023

Adanya Peraturan Presiden Nomor 55 Tahun 2019 tentang Percepatan Program Kendaraan Bermotor Listrik Berbasis Baterai (Battery Electric Vehicle atau BEV) untuk Transportasi Jalan menunjukkan bahwa Indonesia telah menyatakan kesiapannya dalam memasuki era kendaraan listrik. Saat ini produksi motor listrik dengan merek lokal sangat sedikit. Mengetahui hal tersebut, X Group melihat menyusun pembuatan serta pengembangan kendaraan listrik roda dua dari bermesin engine hingga listrik. Penelitian ini bertujuan melakukan perancangan dan pembuatan prototipe motor listrik BLDC 350W dan 3000W. Metode yang digunakan pada penelitian ini adalah Research and Development. Inovasi produk harus dilakukan untuk menyesuaikan perubahan tersebut. Motor yang sudah difabrikasi dilakukan pengujian. Hasilnya diperoleh spesifikasi kebutuhan motor BLDC untuk sepeda listrik memiliki daya masukan sebesar 350 Watt dan tegangan sebesar 36 Volt dengan kecepatan dan torsi masing-masing adalah 500 rpm dan 5,35 Nm. Sedangkan spesifikasi kebutuhan motor BLDC untuk kendaraan roda dua (kendaraan motor listrik) memiliki daya masukan sebesar 3000 Watt dan tegangan sebesar 72 Volt dengan kecepatan dan torsi masing – masing adalah 1241,4 rpm dan 48,86 N.
Analisis struktur pasar rumput laut di Kabupaten Buton Selatan
Authors: Kardianto La Ode , Sarinah  , Riani Irdam , Siang Roslindah Daeng , Sidiq Azwar 
Published: September 2023

Penelitian ini bertujuan untuk mengetahui struktur pasar rumput laut. Teknik penarikan sampel dalam penelitian ini adalah menggunakan rumus Slovin dengan standar eror sebesar 10%. Metode analisis struktur pasar rumput laut meliputi pangsa pasar, hambatan keluar masuk pasar dan pengetahuan pasar rumput laut. Hasil penelitian menunjukkan bahwa struktur pasar rumput laut yang ada di Kabupaten Buton Selata adalah pangsa pasar 2 pedagang pengumpul memiliki selisih 44% dari total penjualan, hambatan untuk masuk kepemasaran rumput laut cukup besar karena nilai MES diatas 10%. Penentuan harga rumput laut ditentukan oleh pedagang pengumpul kota yang sudah disesuaikan dengan harga penjualan rumput laut di Makassar. Oleh karena itu, praktek penentuan harga yang terjadi dalam pemasaran rumput laut tersebut mengarah kepada pasar oligopsoni.
Analisis keuntungan pelaku usaha kerang kalandue (Polymesoda erosa) pada ekosistem mangrove di Kelurahan Korumba Kecamatan Mandonga Kota Kendari
Authors: Firdaus  , Nurdiana A  , Piliana Wa Ode , Rosmawati  , La Ola La Onu , Patiung Seventry Meliana 
Published: September 2023

Penelitian ini bertujuan untuk mengetahui total biaya, penerimaan dan keuntungan pada penangkapan dan pemasaran kerang mangrove (Polymesoda erosa) di ekosistem mangrove. Penelitian ini dilaksanakan pada Bulan April 2022 di Kelurahan Korumba Kecamatan Mandonga Kota Kendari. Metode penarikan sampel yang digunakan yaitu metode sensus dengan jumlah responden 8 orang nelayan penangkap kerang mangrove. Pengumpulan data dilakukan melalui wawancara, observasi dan dokumentasi. Analisis data yang digunakan adalah analisis biaya, analisis penerimaan dan analisis keuntungan. Penangkapan kerang dilakukan oleh suami sedangkan istri nelayan bertanggung jawab untuk melakukan penjualan kerang. Sebagian kecil hasil tangkapan diambil untuk konsumsi pribadi dan sebagian besar dijual. Jumlah tangkapan rata-rata perbulan adalah 276 kg. Hasil analisis menunjukan bahwa rata-rata total biaya per bulan yang dikeluarkan sebesar Rp 488.150. Besaran rata-rata penerimaan per bulan adalah Rp1.381.875. Rata-rata keuntungan per bulan yang diperoleh sebesar Rp 876.100. Artinya penangkapan kerang mangrove pada ekosistem mangrove di Kelurahan Korumba Kecamatan Mandonga Kota Kendari menguntungkan.
Hybrid surgery management challenges of a Behcet's disease patient with recurrence of aortic aneurysms: a case report
Authors: Chen Guo Xin , Wan Jiang Hong , Chen Chu Wen , Huang Bin 
Published: September 2023

BackgroundBehcet's disease is a vasculitis of unknown origin that can involve multiple organs or tissues. Aneurysm or pseudoaneurysm, also one of the complications of Behcet's disease, is usually accompanied by a poor prognosis. Surgery is usually accompanied by a high risk of complications, such as the recurrence of anastomotic pseudoaneurysms and blockage of the target vessel. Using hybrid surgery, we successfully treated a complex and recurrent abdominal aortic pseudoaneurysm in a patient with BD.MethodsWe report a 32-year-old female diagnosed with Behcet's disease with recurrent thoracoabdominal aortic aneurysm. Adequate immunotherapy was given during the perioperative period. The splanchnic artery branches were reconstructed, and the aneurysm was sequestered with endovascular repair. The patient recovered uneventfully and was discharged from the hospital 8 days after hybrid surgery. At the 60-month follow-up, no aneurysm was observed, the stent had no displacement or internal leakage, and the reconstructed blood vessels were unobstructed.ConclusionHybrid surgery could be a feasible and effective strategy for BD aneurysms. Adequate preoperative and postoperative immunotherapy with arterial anastomosis away from the diseased artery may be the key to success.
Modelling the pathology and treatment of cardiac fibrosis in vascularised atrial and ventricular cardiac microtissues
Authors: Reyat Jasmeet S. , di Maio Alessandro , Grygielska Beata , Pike Jeremy , Kemble Samuel , Rodriguez-Romero Antonio , Simoglou Karali Christina , Croft Adam P. , Psaila Bethan , Simões Filipa , Rayes Julie , Khan Abdullah O. 
Published: September 2023

IntroductionRecent advances in human cardiac 3D approaches have yielded progressively more complex and physiologically relevant culture systems. However, their application in the study of complex pathological processes, such as inflammation and fibrosis, and their utility as models for drug development have been thus far limited.MethodsIn this work, we report the development of chamber-specific, vascularised human induced pluripotent stem cell-derived cardiac microtissues, which allow for the multi-parametric assessment of cardiac fibrosis.ResultsWe demonstrate the generation of a robust vascular system in the microtissues composed of endothelial cells, fibroblasts and atrial or ventricular cardiomyocytes that exhibit gene expression signatures, architectural, and electrophysiological resemblance to in vivo-derived anatomical cardiac tissues. Following pro-fibrotic stimulation using TGFβ, cardiac microtissues recapitulated hallmarks of cardiac fibrosis, including myofibroblast activation and collagen deposition. A study of Ca2+ dynamics in fibrotic microtissues using optical mapping revealed prolonged Ca2+ decay, reflecting cardiomyocyte dysfunction, which is linked to the severity of fibrosis. This phenotype could be reversed by TGFβ receptor inhibition or by using the BET bromodomain inhibitor, JQ1.DiscussionIn conclusion, we present a novel methodology for the generation of chamber-specific cardiac microtissues that is highly scalable and allows for the multi-parametric assessment of cardiac remodelling and pharmacological screening.
Sediment variability in intermittently extracted sandbanks in the Belgian part of the North Sea
Authors: Kint Lars , Barette Florian , Degrendele Koen , Roche Marc , Van Lancker Vera 
Published: September 2023

Introduction: In the Belgian part of the North Sea, sand for beach and foreshore nourishments is extracted from the Hinder Banks, about 40 km offshore. The extraction is not screened for shells and other very coarse material, as is the case for sand extraction for industrial use. Intermittent but intensive sand extraction took place from 2012 to 2019 on the Oosthinder, and since 2019 on the Noordhinder.Methods: To better understand sediment variability during human-induced disturbance of the seabed, both sandbanks have been monitored using multibeam bathymetry and backscatter, and Reineck box cores on board of the Research Vessel Belgica A962. Acoustic and sediment data were preferably jointly collected within a one-week period to substantiate the interrelationships.Result: Very well-sorted medium sands with low backscatter values (−28 to −33 dB) are detected near the top of the sandbank, while (moderately) well-sorted coarser sands and shell fragments with high backscatter values (−20 to −24 dB) are detected in the deeper parts of the sandbank slope. Although natural conditions such as sandwave movement and storms may mask early sediment changes, 7 years of intermittent and intensive sand extraction on the upper parts of a gentle sandbank slope caused a seabed deepening of at least 2 m, a backscatter decrease between 5 and 8 dB, a reduction in carbonate content by 1%–5% and an increase in organic matter content by 1%–2%. Two years after the cessation of the operations, the carbonate content increased and organic matter content decreased by 1%–2%.Discussion: Natural variability of sediments remains dependent on depth and geomorphology in both undisturbed, as well as recently and longer disturbed sandbank systems. However, a spreading of the more homogeneous, very well-sorted medium sands with limited carbonate content from the sandbank crest to the upper parts of the sandbank slope was observed, as sand extraction progressed. Subsequently, possible first signs of a slow return to the original sediment characteristics were detected.
Effects of insulin therapy optimization with sensor augmented pumps on glycemic control and body composition in people with cystic fibrosis-related diabetes
Authors: Grancini V. , Alicandro G. , Porcaro L. L. , Zazzeron L. , Gramegna A. , Morlacchi L. C. , Rossetti V. , Gaglio A. , Resi V. , Daccò V. , Blasi F. , Orsi E. 
Published: September 2023

ObjectiveCystic fibrosis (CF)-related diabetes (CFRD) resulting from partial-to-complete insulin deficiency occurs in 40-50% of adults with CF. In people with CFRD, poor glycemic control leads to a catabolic state that may aggravate CF-induced nutritional impairment and loss of muscle mass. Sensor augmented pump (SAP) therapy may improve glycemic control as compared to multiple daily injection (MDI) therapy.Research design and methodsThis non-randomized clinical trial was aimed at evaluating the effects of insulin therapy optimization with SAP therapy, combined with a structured educational program, on glycemic control and body composition in individuals with insulin-requiring CFRD. Of 46 participants who were offered to switch from MDI to SAP therapy, 20 accepted and 26 continued the MDI therapy. Baseline demographic and clinical characteristics were balanced between groups using a propensity score-based overlap weighting procedure and weighted mixed-effects regression models were used to estimate changes in study outcomes.ResultsAfter 24 months changes in HbA1c were: -1.1% (-12.1 mmol/mol) (95% CI: -1.5; -0.8) and -0.1% (-1 mmol/mol) (95% CI: -0.5; 0.3) in the SAP and MDI therapy group, respectively, with a between-group difference of -1.0 (-10 mmol/mol) (-1.5; -0.5). SAP therapy was also associated with a decrease in mean glucose (between group difference: -32 mg/dL; 95% CI: -44; -20) and an increase in TIR (between group difference: 19.3%; 95% CI 13.9; 24.7) and in fat-free mass (between group difference: +5.5 Kg, 95% CI: 3.2; 7.8).ConclusionTherapy optimization with SAP led to a significant improvement in glycemic control, which was associated with an increase in fat-free mass.
Simultaneous series and shunt earth fault detection and classification using the Clarke transform for power transmission systems under different fault scenarios
Authors: Esmail Ehab M. , Alsaif Faisal , Abdel Aleem Shady H. E. , Abdelaziz Almoataz Y. , Yadav Anamika , El-Shahat Adel 
Published: September 2023

For high-voltage (symmetric and non-symmetric) transmission networks, detecting simultaneous faults utilizing a single-end-based scheme is complex. In this regard, this paper suggests novel schemes for detecting simultaneous faults. The proposed schemes comprise two different stages: fault detection and identification and fault classification. The first proposed scheme needs communication links among both ends (sending and receiving) to detect and identify the fault. This communication link between both ends is used to send and receive three-phase current magnitudes for sending and receiving ends in the proposed fault detection (PFD) unit at both ends. The second proposed scheme starts with proposed fault classification (PFC) units at both ends. The proposed classification technique applies the Clarke transform on local current signals to classify the open conductor and simultaneous faults. The sign of all current Clarke components is the primary key for distinguishing between all types of simultaneous low-impedance and high-impedance faults. The fault detection time of the proposed schemes reaches 20 ms. The alternative transient program (ATP) package simulates a 500 kV–150-mile transmission line. The simulation studies are carried out to assess the suggested fault detection and identification and fault classification scheme performance under various OCFs and simultaneous earth faults in un-transposed and transposed TLs. The behavior of the proposed schemes is tested and validated by considering different fault scenarios with varying locations of fault, inception angles, fault resistance, and noise. A comparative study of the proposed schemes and other techniques is presented. Furthermore, the proposed schemes are extended to another transmission line, such as the 400 kV–144 km line. The obtained results demonstrated the effectiveness and reliability of the proposed scheme in correctly detecting simultaneous faults, low-impedance faults, and high-impedance faults.
Persistence of immunological memory as a potential correlate of long-term, vaccine-induced protection against Ebola virus disease in humans
Authors: McLean Chelsea , Dijkman Karin , Gaddah Auguste , Keshinro Babajide , Katwere Michael , Douoguih Macaya , Robinson Cynthia , Solforosi Laura , Czapska-Casey Dominika , Dekking Liesbeth , Wollmann Yvonne , Volkmann Ariane , Pau Maria Grazia , Callendret Benoit , Sadoff Jerry , Schuitemaker Hanneke , Zahn Roland , Luhn Kerstin , Hendriks Jenny , Roozendaal Ramon 
Published: September 2023

IntroductionIn the absence of clinical efficacy data, vaccine protective effect can be extrapolated from animals to humans, using an immunological biomarker in humans that correlates with protection in animals, in a statistical approach called immunobridging. Such an immunobridging approach was previously used to infer the likely protective effect of the heterologous two-dose Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine regimen. However, this immunobridging model does not provide information on how the persistence of the vaccine-induced immune response relates to durability of protection in humans.Methods and resultsIn both humans and non-human primates, vaccine-induced circulating antibody levels appear to be very stable after an initial phase of contraction and are maintained for at least 3.8 years in humans (and at least 1.3 years in non-human primates). Immunological memory was also maintained over this period, as shown by the kinetics and magnitude of the anamnestic response following re-exposure to the Ebola virus glycoprotein antigen via booster vaccination with Ad26.ZEBOV in humans. In non-human primates, immunological memory was also formed as shown by an anamnestic response after high-dose, intramuscular injection with Ebola virus, but was not sufficient for protection against Ebola virus disease at later timepoints due to a decline in circulating antibodies and the fast kinetics of disease in the non-human primates model. Booster vaccination within three days of subsequent Ebola virus challenge in non-human primates resulted in protection from Ebola virus disease, i.e. before the anamnestic response was fully developed.DiscussionHumans infected with Ebola virus may benefit from the anamnestic response to prevent disease progression, as the incubation time is longer and progression of Ebola virus disease is slower as compared to non-human primates. Therefore, the persistence of vaccine-induced immune memory could be considered as a potential correlate of long-term protection against Ebola virus disease in humans, without the need for a booster.
Comparison of crystalloid and colloid co-load combined with norepinephrine prophylaxis on post-spinal anesthesia hypotension during cesarean delivery: a randomized sequential allocation dose-finding study
Authors: Chen Yi , Xu Xiangzhao , Qin Rui , Guo Lei , Ni Xinli 
Published: September 2023

BackgroundFluid loading is an essential component of treatment for reducing the incidence of post-spinal anesthesia hypotension and is necessary to maintain intravascular volume, perfuse tissues, and control spinal anesthesia hypotension after sympathetic blockade. We performed a randomized sequential allocation dose-finding study to compare the effects of 10 mL/kg crystalloid and 6% hydroxyethyl starch (130/0.4) co-load on the ED90 of prophylactic norepinephrine infusion for preventing post-spinal anesthesia hypotension during cesarean delivery.MethodsEighty patients were randomly allocated to receive either a 10 mL/kg crystalloid (Crystalloid Group, n = 40) or 6% hydroxyethyl starch (130/0.4) (Colloid Group, n = 40) co-load combined with prophylactic norepinephrine infusion during spinal anesthesia for cesarean delivery. The first patient received an initial prophylactic norepinephrine infusion rate of 0.025 μg/kg/min. Subsequent patients received a 0.005 μg/kg/min gradient dose of prophylactic norepinephrine. This dose was administered as a gradient based on its effectiveness for preventing post-spinal anesthesia hypotension (defined as SBP &lt; 80% of baseline value) and determined by the up-and-down sequential allocation methodology. The primary study outcome was the ED90 of prophylactic norepinephrine infusion. Secondary outcomes included the incidence of post-spinal anesthesia hypotension, bradycardia, hypertension, Apgar scores, and umbilical artery blood gas values were also measured.ResultsThe ED90 values of prophylactic norepinephrine infusion for preventing post-spinal anesthesia hypotension during cesarean delivery were 0.063 μg (95% CI: 0.050 to 0.064) and 0.062 μg (95% CI: 0.045 to 0.064) using isotonic regression analysis, and 0.068 μg (95% CI: 0.056 to 0.353) and 0.060 μg (95% CI: 0.050 to 3.590) using probit regression analysis in the Crystalloid Group and Colloid Group, respectively. The secondary outcomes were comparable between the two groups.ConclusionThe administration of a 10 mL/kg 6% hydroxyethyl starch (130/0.4) does not provide additional benefits compared to crystalloid co-load in reducing the ED90 of prophylactic norepinephrine infusion for preventing post-spinal anesthesia hypotension during cesarean delivery.
Protective effect of carbon dots derived from scrambled Coptidis Rhizoma against ulcerative colitis in mice
Authors: Mou Yanfang , Bai Xue , Ma Huagen , Li Tingjie , Zhao Yafang , Wu Tong , Zhang Yue , Qu Huihua , Kong Hui , Wang Xueqian , Zhao Yan 
Published: September 2023

Graphical AbstractSchematic diagram of the synthesis of SCR-CDs and diagram of the experimental protocol.