bluuebunny/crossref_metadata_2025_split huggingface dataset:
The dirty side of clean energy: Lithium ion batteries as a source of PFAS in the environment
Authors: Guelfo Jennifer , Ferguson P. , Beck Jonathan , Chernick Melissa , Doria-Manzur Alonso , Faught Patrick , Flug Thomas , Gray Evan , Jayasundara Nishad , Knappe Detlef , Joyce Abigail , Meng Pingping , Shojaei Marzieh 
Published: August 2023

Abstract

Lithium ion batteries (LiBs) are used globally as a key component of clean and sustainable energy iinfrastructure1,2. Emerging LiB technologies have incorporated a novel class of per- and polyfluoroalkyl substances (PFAS, i.e., "forever chemicals") known as bis-perfluoroalkyl sulfonimides (bis-FASIs)3–8. PFAS are recognized internationally as recalcitrant, mobile, and toxic environmental contaminants9. Despite this, virtually nothing is known about environmental impacts of bis-FASIs released during LiB manufacture, use, and disposal. Here we demonstrate that occurrence, ecotoxicity, and treatability of this novel class of PFAS are comparable to PFAS that are now prohibited and highly regulated worldwide10–15 and confirm the clean energy sector as an unrecognized and growing source of global PFAS release. U.S. and European surface water, soil, and sediment measurements confirmed bis-FASI release internationally at concentrations as high as 2,437 parts per trillion (ppt). Toxicity data demonstrated effects on swimming behavior in Daphnia magna at bis-FASI exposures of 10 ppt and swimming behavior and metabolic process changes in Danio rerio resulting from exposures of 25 ppt. Occurrence of up to 881 ppt of bis-FASIs in landfill leachates highlights current impacts of LiB disposal. Although fully recalcitrant to advanced oxidation processes, select bis-FASIs were removed from water during adsorptive treatment with similar or better efficiency as more hydrophobic PFAS such as perfluorooctane sulfonate (PFOS). LiB use is anticipated to increase globally over the next decade, and 8 million tons of LiB waste are projected by 2040 as a result of low recycling rates16. This suggests that environmental exposure to this novel, unregulated class of PFAS will increase with time and will be relevant to the majority of the world's population. Results underscore that environmental impacts of clean energy infrastructure merit scrutiny to ensure that reduced CO2 emissions are not achieved at the expense of increasing global releases of persistent organic pollutants.
Physical Understanding of the tropical cyclone intensity and size relations over the North Indian Ocean
Authors: Nekk Yerni Srinivas , Osuri Krishna Kishore , Mohapatra M 
Published: August 2023

Abstract

Tropical cyclone (TC) size and intensity define the potential destructiveness in the land-falling region. This study investigates the inter-relationships between size parameters (radius of maximum wind, Rmax; 34-knots wind, R34; and TC-fullness, TCF) and intensity. The best-track (size and intensity) data is obtained from Joint Typhoon Warning center during 2002–2021. The frequently observed R34, Rmaxand TCF are 100–150 km, 20–60 km, and 0.8, respectively for NIO TCs. Intensity and TCF are strongly related (0.7) than R34 (0.5) and Rmax(0.6). Analysis shows that size changes are weakly related to intensity changes (0.37–0.39). Diagnostic analysis has been conducted to address possible reasons for different TC groups 1) TCs with no size variation with intensity (Group-1), (2) both increase (Group-2), (3) size increases with no intensity change (Group-3), (4) Initial more size (Group-4). The dry air intrusion outside the eyewall in Group-1 TCs in low vertical wind shear condition limit rain-bands development, enabling moisture convergence into the primary eyewall that helps maintaining storm intensity without R34 increase. Strong surface fluxes in primary eyewall region supports convection and absolute angular momentum (AAM) at upper and lower levels, which boosts size and intensity in Group-2 TCs. Strong and broader surface fluxes and vertical velocities may create rain-bands or secondary-eyewall, causing bigger TCs with limited intensification in Group-3 TCs. Larger initial TC vortices maintains wider and intense surface fluxes, vertical velocities, and AAM in the TC inner and outer cores, supporting maintenance of larger TC size in Group-4.
MTDH Promotes Cancer Stem Cell Phenotypes and Correlated with Immune Infiltration in Hepatocellular Carcinoma
Authors: Wang Yiying , Shen Meimei , Gao Jian 
Published: August 2023

Abstract
Purpose
MTDH (Metadherin) has been suggested as one of the key oncogenes in most cancer types, including hepatocellular carcinoma. The aim of this study was to investigate the role of MTDH in hepatocellular carcinoma on stemness and immune infiltration.
Methods
MTDH expression in HCC tissues was detected using TCGA and GEO databases. Immunohistochemistry was used to analyze tissue samples. MTDH was stably knocked down or overexpressed by transfection with lentivirus in two HCC cell lines. Invasive and migratory abilities were evaluated using matrigel invasion and wound healing assays.Western blotting and qRT-PCR were used to determine gene expression. Flow cytometry, immunofluorescence, and tumor sphere formation assays were used to identify stem-like cell characterization. MTDH inhibition was evaluated in vivo for its effects on tumor growth. The correlation of MTDH with immune cells, immunomodulators, and chemokines was analyzed through the ssGSEA and TISIDB databases.
Results
The expression of MTDH is increased in hepatocellular carcinoma and leads to poor prognosis. HCC cells overexpressing MTDH invaded and migrated more, exhibited a stem cell-like phenotype, and formed spheres. MTDH inhibition attenuated these effects. In vivo, inhibition of MTDH suppressed HCC progression and expression of CD133. MTDH was positively correlated with immature dendritic cells, Th2 cells, central memory CD8 T cell, memory B cell, and CXCL2. MTDH was negatively associated with activated CD8 T cell, eosinophil, activated B cell, monocyte, CX3CL1, and CXCL12.
Conclusions
High levels of MTDH expression in HCC patients are associated with poor prognosis, promoting tumour stemness, immune infiltration and HCC progression.
Water budget study for groundwater recharge in Indus River Basin, Punjab (Pakistan)
Authors: Zakir-Hassan Ghulam , Akhtar Saleem , Shabir Ghulam , Hassan Faiz Raza , Ashraf Hadeed , Sultan Muhammad 
Published: July 2023

Abstract
Assessing groundwater recharge is crucial for managing and governing water resources in any region. Indus River Basin (IRB) is an area that relies heavily on canal and groundwater irrigation. The replenishment of groundwater is largely dependent on surface water supplies. The purpose of this research is to determine the amount of groundwater recharge from various sources in Rachna Doab. The study employed the water budget method to calculate seasonal groundwater recharge during the Rabi (October–March) and Kharif (April–September) (Summer) periods from 2005 to 2011. The main components of the recharge were rainfall, water conveyed through channels, and irrigation water applied to cultivated fields. Conversely, the extraction of water from private and public tube wells was the discharge component of the study. Groundwater levels increased during the Kharif season but decreased during the Rabi season. Average recharge contribution from rainfall was 45 and 14% during the Kharif and Rabi seasons, respectively. The total annual recharge from watercourses and irrigation fields was estimated to be approximately 33% of the total recharge. Rainfall was the most significant source of long-term seasonal recharge, followed by watercourses and irrigation fields. In general, the average depletion of the reservoir was 94 million cubic meters per season.
Lessons learned from a Tiger Worm Toilet implementation project in Sierra Leone
Authors: Sioné Laure , Bastable Andy , Ampilan Abdullah , Templeton Michael R. 
Published: July 2023

Abstract

This paper discusses the implementation of Tiger Worm Toilets (TWTs) as a sustainable alternative to pit latrines in areas with challenging environmental conditions. The study was carried out in Koinadugu, Sierra Leone, where TWTs were installed in 200 households, providing safe sanitation for approximately 1,200 individuals within a 17-month period. The study reveals that TWTs offer several benefits over traditional pit latrines, including higher cost efficiency. Despite some setbacks, TWTs have been well-received by the local communities, resulting in a significant reduction in open defaecation in areas where latrines are not viable. The study presents areas of further research and concludes with recommendations for future TWT designs based on the lessons learned.
Study on Gamma selection in the optimal operation of secondary water supply system based on deep Q-learning network
Authors: Geng Weimin , Yan Jun , Xie Shanbin , Zhang Dian 
Published: July 2023

Abstract

When the requirements for water pressure and quantity of drinking water for residents and industrial buildings exceed the capacity of the urban water distribution system, a secondary water supply system (SWSS) is supplied to users by pipelines through storage, pressurization, and other facilities. In China, SWSS has been installed in 97% of residential buildings and the operation of SWSS is directly related to the water pressure and water quality of the users' tap water. In this paper, the operation optimization objectives for the SWSS with storage facilities were proposed, and deep Q-learning network (DQN) was applied to optimize the control of SWSS. In this study, the pressure, the water age in the roof water tank, and the power consumption of the pumps were selected as the optimization objectives. The equation for the qualitative selection of the key hyperparameter (Gamma) was proposed and verified by the experiments in a community of City S in East China. The results indicated that with the decrease in the volume of the water tank, the larger Gamma value was recommended, and the more future conditions were considered. It is hoped that the result can be used as a reference in SWSS operation optimization.
Potential uses of Topical Resiquimod for Mycosis Fungoides Tumor Stage
Authors: Boretti Alberto 
Published: August 2023

Introduction:
Resiquimod (formula C17H22N4O2, ChEMBL Id 383322) is an immune response modifier that stimulates immune responses to tumor lesions mostly through toll-like receptors (TLR) 7 and 8 dependent pathways.

Methods:
This study considers the potential use of Resiquimod in the topical treatment of myco-sis fungoides tumor stage, for which standard-of-care is radiation therapy which has a very well-known dosage-effects relationship and efficacy, but also side effects, and also the limitation re-garding the number of times a same area can be treated during a lifetime.

Result:
Trials are suggested to evaluate the use of Resiquimod as a replacement for radiation therapy in case of shallow lesions, as well as a supporting agent to increase the efficacy and re-duce the dosage of the radiation therapy, lessening the side effects, and permitting many more uses for a same treatment zone.

Conclusion:
This study proposes more research for the possible use of Resiquimod in the standalone or synergetic treatment of MF tumor phase, as there is potential, but not yet evidence, for these uses.
To evaluate safety and efficacy of Keshohills hair oil in subjects with mild to moderate hair fall and dandruff
Authors: Ajitkumar Mandlecha  , Gous Shaukatali Mujawar  
Published: July 2023

Introduction - Hair fall is one of the minor diseases which is affecting approximately 1.7% of the world population and challenging task for physicians. Treating Hair issues with ayurvedic medicated oils have gained importance due to the safety and efficacy of their use. Keshohills hair oil is Ayurvedic proprietary medicine formulated as oil with herbs aimed at reducing hair fall and scalp dandruff. Objective - The aim of this clinical study was to evaluate the effectiveness of Keshohills hair oil in the management of hair fall and dandruff of the scalp in adults. Materials and Methods - 50 healthy respondents were enrolled and completed the period of study positively. The 60 Second Hair Comb Test, Adherent Scalp Flaking Score, Objective Hair Assessment Questionnaire, were used in the study. Conclusion - Keshohills hair oil was effective in reducing hair loss, treating Seborrheic dermatitis.
Aromatherapy: A New Pragmatism in Dentistry [Part-2]
Authors: Supriya PR  , N Nandan , N Sunil Raj , C Anitha , Vishwanathan Soundarya 
Published: July 2023

A new and alternative way to reduce anxiety levels in dental clinics is the use of aromatherapy. Aromatherapy uses plant materials and aromatic plant oils, including essential oils and other aroma compounds for improving psychological or physical well-being. Number of studies has been done to prove the therapeutic properties of various essential oils, but very few have been published on their use in dentistry. This review is a continuation of previous article which will provide an overview of remaining essential oils, including their therapeutic properties and applications in dentistry.
Effect of Shashti Shali Pinda Swedan and Sahchar Tail Matra Basti in the management of Young Onset of Parkinson Disorder (YOPD) - A Case Report
Authors: Chhaya Baghel  , Babita Dash  , Harsha Gupta  
Published: July 2023

The young onset Parkinson disease is a progressive neurodegenerative disease characterized by both motor and non motor features. The diseases affect families and caregivers through its progressive degenerative effect on mobility and the muscle control.[1] The main difference between young onset of Parkinson disorder (YOPD)and the late onset of Parkinson disorder (LOPD) is genetic etiology and clinical symptoms e.g., dystonia and levodopa induced per dyskinesia are common in YOPD. YOPD person carrying a greater social economic burden compared to late onset of Parkinson disease due to age factor. YOPD Patients more prone to levodopa related motor complication. Parkinson’s disease is referred to in the ancient Indian medical system of Ayurveda under the name Kampavata which is characterized by Kampa (Tremors), Stambha (Rigidity), Chesthahani (Akinesia) & Gativikriti (Gait Disorders). The case study is of a 45 years old male who has been diagnosed with early stage idiopathic Parkinson’s disease. No satisfactory treatment is seen in contemporary system of medicine so treatment is planned in here study.
Telephone-Based Intervention to Improve Family Planning Care in Pregnancies of Unknown Location: Retrospective Pre-Post Study
Authors: Flynn Anne Nichols , Koelper Nathanael C , Sonalkar Sarita 
Published: July 2023

Background
Patients followed for a pregnancy of unknown location are generally followed by a team of clinicians through telephone calls, and their contraceptive needs at the time of pregnancy resolution may not be addressed.

Objective
This study aimed to assess contraceptive counseling and contraceptive uptake before and after a telephone-based intervention.

Methods
This was a retrospective pre-post study assessing pregnancy intendedness in patients with a pregnancy of unknown location and the proportion of patients who received contraceptive counseling and a contraceptive prescription before and after the initiation of a telephone-based intervention. We reviewed medical records 1 year before and 1 year after implementation of our intervention for demographic characteristics, pregnancy intendedness, pregnancy outcome, contraceptive counseling documentation, receipt of contraception, and repeat pregnancy within 6 months. We assessed the effects of an implementation strategy to address family planning needs once pregnancy was resolved by comparing the proportions of patients who were counseled and received contraception before and after our intervention was implemented. We performed logistic regression to identify associations between covariates and the outcomes of contraceptive counseling documentation and receipt of contraception.

Results
Of the 220 patients in the combined cohort, the majority were Black (161/220, 73%) and ultimately had a resolved pregnancy of unknown location (162/220, 74%), and the proportion of pregnancies documented as unintended was 60% (132/220). Before our intervention, 27 of 100 (27%) patients received contraceptive counseling, compared with 94 of 120 (78%) patients after the intervention (odds ratio [OR] 9.77, 95% CI 5.26-18.16). Before the intervention, 17 of 90 (19%) patients who did not desire repeat pregnancy received contraception, compared with 32 of 86 (37%) patients after the intervention (OR 2.54, 95% CI 1.28-5.05). Our postintervention cohort had an increased odds of receiving contraceptive counseling (OR 9.77, 95% CI 5.26-18.16) and of receiving a contraceptive prescription (OR 2.54, 95% CI 1.28-5.05) compared with our preintervention cohort.

Conclusions
We found that over half of patients with a pregnancy of unknown location have an unintended pregnancy, and standardization of care through a telephone-based intervention improves contraceptive counseling and prescribing in patients with a resolved pregnancy of unknown location. This intervention could be used at any institution that follows patients with a pregnancy of unknown location remotely to improve care.
Digitally Delivered Interventions to Improve Nutrition Behaviors Among Resource-Poor and Ethnic Minority Groups With Type 2 Diabetes: Systematic Review
Authors: Karimi Nazgol , Opie Rachelle , Crawford David , O’Connell Stella , Ball Kylie 
Published: July 2023

Background
Resource-poor individuals, such as those with a low income, are disproportionately affected by diabetes and unhealthy eating patterns that contribute to poor disease self-management and prognosis. Digitally delivered interventions have the potential to address some of the barriers to healthy eating experienced by this group. However, little is known about their effectiveness in disadvantaged populations.

Objective
This systematic review is conducted to assess the effectiveness of digitally delivered interventions in improving nutritional behaviors and nutrition‐related health outcomes among disadvantaged people with type 2 diabetes (T2D).

Methods
MEDLINE complete, Global Health, Embase, CINAHL complete, Informit Health, IEEE Xplore, and Applied Science and Technology Source databases were searched for studies published between 1990 and 2022 on digitally delivered nutrition interventions for disadvantaged people with T2D. Two reviewers independently assessed the studies for eligibility and determined the study quality using the Cochrane Risk-of-Bias Assessment Tool. The Behavioral Change Technique Taxonomy V1 was used to identify behavior change techniques used in the design of interventions.

Results
Of the 2434 identified records, 10 (0.4%), comprising 947 participants, met the eligibility criteria and were included in the review. A total of 2 digital platforms, web and messaging services (eg, SMS text messaging interventions or multimedia messaging service), were used to deliver interventions. Substantial improvements in dietary behaviors were reported in 5 (50%) of the 10 studies, representing improvements in healthier food choices or increases in dietary knowledge and skills or self-efficacy. Of the 10 studies, 7 (70%) examined changes in blood glucose levels, of which 4 (57%) out of 7 achieved significant decreases in hemoglobin A1C levels ranging from 0.3% to 1.8%. The most frequently identified behavior change techniques across all studies were instruction on how to perform the behavior, information about health consequences, and social support.

Conclusions
This review provided some support for the efficacy of digitally delivered interventions in improving healthy eating behaviors in disadvantaged people with T2D, an essential dietary prerequisite for changes in clinical metabolic parameters. Further research is needed into how disadvantaged people with T2D may benefit more from digital approaches and to identify the specific features of effective digital interventions for supporting healthy behaviors among disadvantaged populations.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42020149844; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=149844
Kinerja Website Koleksi Langka Perpustakaan UGM Dan Perubahan Perilaku Pemustaka Pada Masa Pandemi Covid-19
Authors: Maryono Maryono 
Published: August 2023

Website koleksi langka digital perpustakaan UGM terus dikembangkan. Analisis kinerja website koleksi langka
digital perpustakaan UGM penting dilakukan. Penelitian ini bertujuan mengetahui asal pengunjung, rerata
jumlah kunjungan, rerata durasi waktu kunjungan, angka pentalan (bounce rate), piranti teknologi pengunjung, asal pencarian pengunjung, dan konten yang diakses pengunjung pada
alamat website http://langka.lib.ugm.ac.id/. Metode web analytics dengan tools aplikasi google analytics digunakan dalam penelitian ini. Pengumpulan data dilakukan selama 4 tahun sejak 18 Oktober 2018 sebelum masa pandemi Covid-19, hingga masa akhir pandemi 31 Desember 2022. Analisis data menghasilkan beberapa temuan penting terkait kinerja website, perubahan perilaku pemustaka dan konten yang diakses. Kunjungan ke website mengalami peningkatan yang cukup signifikan hingga total sejumlah 84.481, sedangkan angka pentalan (bounce rate) mencapai 0,88%. Penggunaan gadget mobile dan penelusuran secara organic search atau melalui mesin pencari (search engine) mulai mendominasi akses ke web langka. Ditemukan bahwa konten berjudul “Kitab primbon Betaljemur adammakna” meraih jumlah halaman terbanyak diakses mencapai 61.747 pageviews. Penelitian bermanfaat sebagai suatu model sistem informasi yang memantau kinerja web dan konten digitalnya yang merupakan hasil digitasi koleksi langka. Informasi empiris yang dihasilkan berguna khususnya dalam kegiatan evaluasi dan monitoring keterpakaian konten digital.
Program Pendambingan Belajar Anak-Anak Dalam Menumbuhkan Rasa Percaya Diri di Desa Reukieh Dayah Aceh Besar
Authors: Yoga Desi 
Published: July 2023

Tujuan dari penelitian ini adalah untuk mendeskripsikan program pendampingan belajar anak-anak dalam menumbuhkan rasa percaya diri serta kendala yang dihadapi dalam pelaksanaan program didesa Reukih dayah, Kecamatan Indrapuri, Kabupaten Aceh Besar. Metode penelitian yang digunakan daam penelitian ini adalah penelitian deskriptif kualitatif dengan menggunakan tehnik observasi, wawancara mendalam, dan dokumentasi. Lokasi dari penelitian ini adalah desa Reukih Dayah, Kecamatan Indrapuri, Kabupaten Aceh Besar. Adapun sasaran atau subjek dalam penelitian ini adalah 7 orang anak yang masih berada dibawah umur 13 tahun. Dari hasil penelitian menunjukkan bahwa program pendampingan belajar anak-anak dalam menumbuhkan rasa percaya diri dilaksanakan dengan tahapan perencanaan, pengorganisasian, monitoring dan evaluasi, perencanaan dilakukan dengan cara mengumpulkan peserta didik untuk melakukan tindak lanjut terhadap perencanaan yang sudah di rancang. Dan akhir evaluasi monitoring dilakukan secara berskala. Setelah dilakukan monitoring dan evaluasi secara keseluruhan maka ditemukanlah bahwa kendala dalam pelaksanaan program adalah adanya perbedaan kemampuan dan rasa takut yang besar untuk berdiri didepan. Sehingga timbullah rasa tidak percaya diri terhadap anak-anak yang ada di desa Reukih Dayah.