bluuebunny/crossref_metadata_2025_split huggingface dataset:
Projected changes in extreme precipitation and temperature events over Central Africa from COSMO‐CLM simulations under the global warming level of 1.5°C and above
Authors: Fotso‐Kamga Gabriel , Fotso‐Nguemo Thierry C. , Diallo Ismaila , Nyanchi Godwill T. , Yepdo Zéphirin D. , Chouto Steven , Kaissassou Samuel , Zebaze Sinclaire , Tanessong Roméo S. , Djiotang Tchotchou Lucie A. , Vondou Derbetini A. , Diedhiou Arona , Lenouo André 
Published: August 2023

AbstractThis study explores the response of the increased global warning levels (GWLs) on the spatio‐temporal characteristics of extreme precipitation and temperature events over Central Africa (CA). For this purpose, eight indices proposed by the Expert Team on Climate Change Detection and Indices have been computed based on an ensemble‐mean of simulations from the COnsortium for Small‐scale MOdelling in CLimate Mode (CCLM) regional climate model, under the Representative Concentration Pathways scenario RCP8.5. The ability of CCLM to represent the climatology of considered daily hydro‐climatic extreme indices related to both precipitation and temperature was also assessed. The results showed that despite the presence of some biases, the precipitation and temperature indices are satisfactorily represented by CCLM, with some notable improvements compared to the GCMs driving fields. The climate change signals under 1.5°C GWL threshold show mostly increases (decreases) in SDII, CDD, R95PTOT, T10, T90, WSDI, and DTR (RR1) over CA throughout the year, and these effects intensify towards a warmer world. Singularly, the strongest changes in these extreme events are generally recorded during the JJA season over the northern part of CA. The results also show on one hand a widespread decrease in mean precipitation (up to 2 mm · day−1 corresponding to ~50%) associated with the increase/decrease in CDD/RR1, and on the other hand an increase in mean temperatures (up to 4°C corresponding to ~18%) associated with the increase in both lowest and highest temperatures (T10, T90). This study suggests that the CA region will be prone to droughts and floods as well as heat waves in a warmer world and calls for climate action and adaptation strategies to mitigate the risks associated with the above changes on rain‐fed agriculture, water resource, and human health.
Friends in the village:do they matter for women’s involvement in household decisions?
Authors: D’Exelle Ben , Ignowski Liz 
Published: August 2023

AbstractIt is often assumed that social connections are good for female empowerment in developing countries. However, growing evidence suggests that empowered women may face backlash from their spouse. In this paper, we analyze how the number of friends that wives have in their village affects the wives’ involvement in household decisions about their own health and their children’s health. To do so, we use data from 700 couples in 30 villages in rural Tanzania. We estimate the effect of the number of friends on the wife’s involvement in household decisions using a multinomial logit regression combined with a control function that deals with potential endogeneity bias. We find that wives with more friends are less likely to make decisions jointly with their husband, and are more likely to report that their husband makes decisions without their involvement. We further explore whether the effects depend on the “type” of friends, as defined by their gender and whether they are shared with the husband.
Comparison of manual and artificial intelligence based quantification of myocardial strain by feature tracking—a cardiovascular MR study in health and disease
Authors: Gröschel Jan , Kuhnt Johanna , Viezzer Darian , Hadler Thomas , Hormes Sophie , Barckow Phillip , Schulz-Menger Jeanette , Blaszczyk Edyta 
Published: August 2023

Abstract
Objectives
The analysis of myocardial deformation using feature tracking in cardiovascular MR allows for the assessment of global and segmental strain values. The aim of this study was to compare strain values derived from artificial intelligence (AI)–based contours with manually derived strain values in healthy volunteers and patients with cardiac pathologies.

Materials and methods
A cohort of 136 subjects (60 healthy volunteers and 76 patients; of those including 46 cases with left ventricular hypertrophy (LVH) of varying etiology and 30 cases with chronic myocardial infarction) was analyzed. Comparisons were based on quantitative strain analysis and on a geometric level by the Dice similarity coefficient (DSC) of the segmentations. Strain quantification was performed in 3 long-axis slices and short-axis (SAX) stack with epi- and endocardial contours in end-diastole. AI contours were checked for plausibility and potential errors in the tracking algorithm.

Results
AI-derived strain values overestimated radial strain (+ 1.8 ± 1.7% (mean difference ± standard deviation); p = 0.03) and underestimated circumferential (− 0.8 ± 0.8%; p = 0.02) and longitudinal strain (− 0.1 ± 0.8%; p = 0.54). Pairwise group comparisons revealed no significant differences for global strain. The DSC showed good agreement for healthy volunteers (85.3 ± 10.3% for SAX) and patients (80.8 ± 9.6% for SAX). In 27 cases (27/76; 35.5%), a tracking error was found, predominantly (24/27; 88.9%) in the LVH group and 22 of those (22/27; 81.5%) at the insertion of the papillary muscle in lateral segments.

Conclusions
Strain analysis based on AI-segmented images shows good results in healthy volunteers and in most of the patient groups. Hypertrophied ventricles remain a challenge for contouring and feature tracking.

Clinical relevance statement
AI-based segmentations can help to streamline and standardize strain analysis by feature tracking.

Key Points
• Assessment of strain in cardiovascular magnetic resonance by feature tracking can generate global and segmental strain values.
• Commercially available artificial intelligence algorithms provide segmentation for strain analysis comparable to manual segmentation.
• Hypertrophied ventricles are challenging in regards of strain analysis by feature tracking.
Fructose: a modulator of intestinal barrier function and hepatic health?
Authors: Staltner Raphaela , Burger Katharina , Baumann Anja , Bergheim Ina 
Published: August 2023

Abstract
Purpose
Consumption of fructose has repeatedly been discussed to be a key factor in the development of health disturbances such as hypertension, diabetes type 2, and non-alcoholic fatty liver disease. Despite intense research efforts, the question if and how high dietary fructose intake interferes with human health has not yet been fully answered.

Results
Studies suggest that besides its insulin-independent metabolism dietary fructose may also impact intestinal homeostasis and barrier function. Indeed, it has been suggested by the results of human and animal as well as in vitro studies that fructose enriched diets may alter intestinal microbiota composition. Furthermore, studies have also shown that both acute and chronic intake of fructose may lead to an increased formation of nitric oxide and a loss of tight junction proteins in small intestinal tissue. These alterations have been related to an increased translocation of pathogen-associated molecular patterns (PAMPs) like bacterial endotoxin and an induction of dependent signaling cascades in the liver but also other tissues.

Conclusion
In the present narrative review, results of studies assessing the effects of fructose on intestinal barrier function and their impact on the development of health disturbances with a particular focus on the liver are summarized and discussed.
A magnetic nanoparticle-based microfluidic device fabricated using a 3D-printed mould for separation of Escherichia coli from blood
Authors: Jóskowiak Agnieszka , Nogueira Catarina L. , Costa Susana P. , Cunha Alexandra P. , Freitas Paulo P. , Carvalho Carla M. 
Published: August 2023

AbstractHerein, A microfluidic device is described, produced with a 3D-printed master mould that rapidly separates and concentrates Escherichia coli directly from whole blood samples, enabling a reduction in the turnaround time of bloodstream infections (BSIs) diagnosis. Moreover, it promotes the cleansing of the blood samples whose complexity frequently hampers bacterial detection. The device comprises a serpentine mixing channel with two inlets, one for blood samples (spiked with bacteria) and the other for magnetic nanoparticles (MNPs) functionalized with a (bacterio)phage receptor-binding protein (RBP) with high specificity for E. coli. After the magnetic labelling of bacteria throughout the serpentine, the microchannel ends with a trapping reservoir where bacteria-MNPs conjugates are concentrated using a permanent magnet. The optimized sample preparation device successfully recovered E. coli (on average, 66%) from tenfold diluted blood spiked within a wide range of bacterial load (102 CFU to 107 CFU mL−1). The non-specific trapping, tested with Staphylococcus aureus, was at a negligible level of 12%. The assay was performed in 30 min directly from diluted blood thus presenting an advantage over the conventional enrichment in blood cultures (BCs). The device is simple and cheap to fabricate and can be tailored for multiple bacterial separation from complex clinical samples by using RBPs targeting different species. Moreover, the possibility to integrate a biosensing element to detect bacteria on-site can provide a reliable, fast, and cost-effective point-of-care device.
Graphical abstract
Benign peripheral nerve sheath tumors: an interdisciplinary diagnostic and therapeutic challenge
Authors: Uerschels Anne-Kathrin , Dengler Nora F. , Chihi Mehdi , Lenkeit Annika , Dinger Thiemo F. , Jabbarli Ramazan , Sure Ulrich , Hagenacker Tim , Wrede Karsten H. , Gembruch Oliver 
Published: August 2023

AbstractA benign peripheral nerve sheath tumor (bPNST) is a rare lesion associated with peripheral nerval structures. Symptoms may be heterogeneous, complicating diagnosis finding. Additionally, management concepts of bPNST may vary. In some cases, initial misdiagnosis leads to mistreatment resulting in severe functional deficits and chronic pain syndromes. Therefore, we analyzed patients treated for bPNST in our specialized institution with a primary focus on prior misdiagnosis and possible mistreatment. Patients with bPNSTs (schwannomas, neurofibromas, hybrid nerve sheath tumors, and perineuriomas) treated at the Neurosurgical Department between January 1, 2015, and July 31, 2021, were included. Assessment of demographics, tumor entity, tumor location, symptoms, the interval between the onset of symptoms and surgery, involved medical specialties, and outpatients’ treatment, with particular focus on initial misdiagnosis and inappropriate medical treatment, was performed. Eighty-five patients were included in the final analysis with schwannoma being the most prevalent histopathological diagnosis (schwannoma (75.3%, n=64), neurofibroma (12.9%, n=11), hybrid nerve sheath tumor (5.9%, n=5), and perineurioma (5.9%, n=5)). An incorrect primary diagnosis was detected in 44.7% (n=38), leading to suboptimal or insufficient treatment in these cases. Of those, 28.9% (n=11/38) were treated suboptimal, while 18.5% (n=7/38) underwent unnecessary invasive diagnostics. Inappropriate surgery based on prior misdiagnosis, which led to severe neurological deficits in all these cases, was reported in 26.3% (n=10/38). For the first time, our data shows the quantity and impact of incorrect initial diagnosis in bPNST causing a delay in causative treatment or resulting in unnecessary or potentially harmful treatment.
Social Stories for Promoting Social Communication with Children with Autism Spectrum Disorder Using a Humanoid Robot: Step-by-Step Study
Authors: Silva Vinícius , Pereira Ana Paula , Soares Filomena , Leão Celina P. , Jurdi Andrea , Sena Esteves João , Hertzberg Juliana 
Published: August 2023

AbstractTechnological tools are being used in support sessions with children with autism spectrum disorder (ASD), producing a high level of encouragement and engagement in these individuals. A four-step study comprising a focus group session, thinking aloud sessions, an online questionnaire, and a pilot study was conducted. First, a focus group session was conducted with professionals (n = 10) with different backgrounds that support children with ASD on a daily basis. Considering the outputs from the focus group, thinking aloud sessions with two specialists and an online questionnaire with 138 participants were conducted. Finally, a pilot study with four children with ASD was performed in order to test the constraints of the system. The goal of this article is to present findings concerning the design of social stories in a storytelling game that uses a new object with playware technology (OPT) as tangible interface with children with ASD. The storytelling game allows promoting the recognition of emotions in a triadic setup involving a robot, a child, and a professional or researcher. The key issue in this activity is to find the adequacy of the scenarios. The participants pointed out the main aspects to take into account in the development of the storytelling scenarios. New designs of the story scenarios were developed and the final design of the OPT was elaborated. The pilot study allowed to conclude that the children understood the mechanics of the games and successfully interacted with the new OPT.
Secure Video Streaming Using Dedicated Hardware
Authors: Murray-Hill Nicholas , Fontes Laura , Machado Pedro , Ihianle Isibor Kennedy 
Published: August 2023

AbstractThe purpose of this article is to present a system that enhances the security, efficiency, and reconfigurability of an Internet-of-Things (IoT) system used for surveillance and monitoring. A Multi-Processor System-On-Chip (MPSoC) composed of Central Processor Unit (CPU) and Field-Programmable Gate Array (FPGA) is proposed for increasing the security and the frame rate of a smart IoT edge device. The private encryption key is safely embedded in the FPGA unit to avoid being exposed in the Random Access Memory (RAM). This allows the edge device to securely store and authenticate the key, protecting the data transmitted from the same Integrated Circuit (IC). Additionally, the edge device can simultaneously publish and route a camera stream using a lightweight communication protocol, achieving a frame rate of 14 frames per Second (fps). The performance of the MPSoC is compared to a NVIDIA Jetson Nano (NJN) and a Raspberry Pi 4 (RPI4) and it is found that the RPI4 is the most cost-effective solution but with lower frame rate, the NJN is the fastest because it can achieve higher frame-rate but it is not secure, and the MPSoC is the optimal solution because it offers a balanced frame rate and it is secure because it never exposes the secure key into the memory. The proposed system successfully addresses the challenges of security, scalability, and efficiency in an IoT system used for surveillance and monitoring. The Rivest-Shamir-Adleman (RSA) encryption key is securely stored and authenticated, and the edge device is able to simultaneously publish and route a camera stream feed high-definition images at 14 fps. The proposed system enhances the security, efficiency, and reconfigurability of an IoT system used for surveillance and monitoring. The RSA encryption key is effectively protected by the implementation of an MPSoC with Programmable Logic (PL), which also allows for faster processing and data transmission.
Market entry as a marketplace owner: when and why should you sell on your marketplace?
Authors: Rösch Jürgen 
Published: August 2023

AbstractThe new Digital Market Act (DMA) of the European Union imposes stricter rules on gatekeeper platforms. While this affects only a few very large platforms, the discussion surrounding the implementation of the DMA offers valuable insights into the strategic behaviors of those gatekeeper platforms. A gatekeeper platform, for example, may enter its platform as a supplier, which may hurt existing third-party suppliers and restrict fair competition on the platform. This paper flips the academic discussion on whether marketplace owners should be allowed to sell on their marketplaces. It illustrates why this behavior is profitable for gatekeepers and how marketplace owners can apply this knowledge to improve their business models. The paper identifies five situations in which becoming a supplier in one’s marketplace can be profitable, but it also proposes alternative solutions to entering the market.
Coordinated Metabolic Responses Facilitate Cardiac Growth in Pregnancy and Exercise
Authors: Schulman-Geltzer Emily B. , Collins Helen E. , Hill Bradford G. , Fulghum Kyle L. 
Published: August 2023

Abstract
Purpose of Review
Pregnancy and exercise are systemic stressors that promote physiological growth of the heart in response to repetitive volume overload and maintenance of cardiac output. This type of remodeling is distinct from pathological hypertrophy and involves different metabolic mechanisms that facilitate growth; however, it remains unclear how metabolic changes in the heart facilitate growth and if these processes are similar in both pregnancy- and exercise-induced cardiac growth.

Recent Findings
The ability of the heart to metabolize a myriad of substrates balances cardiac demands for energy provision and anabolism. During pregnancy, coordination of hormonal status with cardiac reductions in glucose oxidation appears important for physiological growth. During exercise, a reduction in cardiac glucose oxidation also appears important for physiological growth, which could facilitate shuttling of glucose-derived carbons into biosynthetic pathways for growth. Understanding the metabolic underpinnings of physiological cardiac growth could provide insight to optimize cardiovascular health and prevent deleterious remodeling, such as that which occurs from postpartum cardiomyopathy and heart failure.

Summary
This short review highlights the metabolic mechanisms known to facilitate pregnancy-induced and exercise-induced cardiac growth, both of which require changes in cardiac glucose metabolism for the promotion of growth. In addition, we mention important similarities and differences of physiological cardiac growth in these models as well as discuss current limitations in our understanding of metabolic changes that facilitate growth.
International Trauma-Informed Practice Principles for Schools (ITIPPS): expert consensus of best-practice principles
Authors: Martin Karen , Dobson Madeleine , Fitzgerald Kate , Ford Madeleine , Lund Stephan , Egeberg Helen , Walker Rebecca , Milroy Helen , Wheeler Keane , Kasten-Lee Amanda , Bayly Lisa , Gazey Angela , Falconer Sarah , Platell Monique , Berger Emily 
Published: August 2023

AbstractRecognition that schools should be responsive to children who are impacted by adversity and trauma is burgeoning internationally. However, consensus regarding the necessary components of a trauma-informed school is lacking. This research developed expert-informed and internationally relevant best-practice trauma-informed principles for schools. A four-phase methodology included (i) identification of school-relevant trauma-informed practice programs, (ii) inductive thematic analysis of the main concepts underlying programs, (iii) phrasing of draft Principles and (iv) Principle revision and finalisation via a two-round Delphi survey with international experts. Excellent agreement by experts on the importance of all Principles was achieved (round 1 ≥ 86.4%, 2 ≥ 92.3%). The final ‘International Trauma-Informed Practice Principles for Schools’ (ITIPPS) include four Overarching (A–D) and 10 Practice Principles (1–10). Summarised, these include that the school: (A) is student focussed; (B) models compassion and generosity; (C) is understanding and responsive; (D) incorporates recognition of their First Nations peoples in the school’s ethos: (1) prioritises safety and wellbeing; (2) models positive relationships; (3) provides a positive culture and connects; (4) consults and collaborates; (5) supports vulnerable students; (6) teaches social and emotional learning; (7) provides trauma-informed practice training; (8) is predictable yet flexible; (9) identifies and nurtures strengths and (10) reflects, changes and grows. The ITIPPS provide clear guidance for education sectors, schools and other settings about appropriate learning environments for children and young people impacted by trauma. Research is now underway in Western Australian schools to pilot test the feasibility and impact of using the ITIPPS within a framework (thoughtfulschools.org.au) to establish trauma-informed schools.
Human parietal epithelial cells (PECs) and proteinuria in lupus nephritis: a role for ClC-5, megalin, and cubilin?
Authors: Ceol Monica , Gianesello Lisa , Trimarchi Hernan , Migliorini Alberto , Priante Giovanna , Radu Claudia M. , Naso Elena , Angelini Annalisa , Calò Lorenzo A. , Anglani Franca , Del Prete Dorella 
Published: August 2023

Abstract
Background
Parietal epithelial cells are a heterogeneous population of cells located on Bowman’s capsule. These cells are known to internalize albumin with a still undetermined mechanism, although albumin has been shown to induce phenotypic changes in parietal epithelial cells. Proximal tubular cells are the main actors in albumin handling via the macromolecular complex composed by ClC-5, megalin, and cubilin. This study investigated the role of ClC-5, megalin, and cubilin in the parietal epithelial cells of kidney biopsies from proteinuric lupus nephritis patients and control subjects and identified phenotypical changes occurring in the pathological milieu.

Methods
Immunohistochemistry and immunofluorescence analyses for ClC-5, megalin, cubilin, ANXA3, podocalyxin, CD24, CD44, HSA, and LTA marker were performed on 23 kidney biopsies from patients with Lupus Nephritis and 9 control biopsies (obtained from nephrectomies for renal cancer).

Results
Two sub-populations of hypertrophic parietal epithelial cells ANXA3+/Podocalyxin−/CD44−, both expressing ClC-5, megalin, and cubilin and located at the tubular pole, were identified and characterized: the first one, CD24+/HSA−/LTA− had characteristics of human adult parietal epithelial multipotent progenitors, the second one, CD24−/LTA+/HSA+ committed to become phenotypically proximal tubular cells. The number of glomeruli presenting hypertrophic parietal epithelial cells positive for ClC-5, megalin, and cubilin were significantly higher in lupus nephritis patients than in controls.

Conclusions
Our results may provide further insight into the role of hypertrophic parietal epithelial cells located at the tubular pole and their possible involvement in protein endocytosis in lupus nephritis patients. These data also suggest that the presence of hypertrophic parietal epithelial cells in Bowman's capsule represents a potential resource for responding to protein overload observed in other glomerulonephritis.

Graphical abstract