bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ghana’s progress towards measles elimination: Surveillance data analysis, Greater Accra Region, 2015 – 2019
Authors: Sheriff Amara Alhaji , Zakariah Adam , Dapaa Samuel , Odikro Magdalene A. , Issahaku Razak G. , Bandoh Delia , Noora Charles L. , Gebru Gebrekrstos N. , Kenu Ernest 
Published: March 2023

IntroductionAlthough measles is targeted for global elimination by 2020, an estimated 869,770 measles cases and 207,500 deaths occurred in 2019. Ghana adopted the World Health Organization measles elimination strategies, however, evidence of a systematic, comprehensive analysis of data tracking progress towards elimination is sparse. We analyzed measles data to describe its epidemiology, surveillance, and vaccination coverage performances in the Greater Accra Region.MethodsWe reviewed and conducted a descriptive analysis of measles surveillance, laboratory, and vaccination data for 2015 to 2019 obtained from the regional health directorate and National public health reference laboratory. Case patients’ demographic and clinical variables were analyzed into frequencies, proportions, and rates. We used WHO measles elimination performance targets; at least one suspected measles case reported per 100,000 population, 80% of suspected measles cases investigated with adequate blood samples, measles incidence &lt;1/1,000,000 population, 95% routine vaccination coverage and during SIAs as benchmarks.ResultsOf 930 suspected measles cases reported, 605(65.1%) were tested. Males accounted for 356(58.8%); 141(23.3%), 342(56.5%), and 122(20.2%), were children &lt;1, 1–4, and ≥5 years old respectively. Of those tested, 10(1.65%) were measles IgM confirmed, of which 7(70.0%) had received at least one dose of measles vaccine. Annualized measles reporting rate ranged from 1.8 to 6.4 per 100,000 population from 2015 to 2019. District specimen collection rate was 100%, and measles incidence was between 0 – 0.6 per million population in the period 2015–2019. Measles vaccination coverage increased from 73.5% in 2016 to 102% in 2019 with 75% of districts achieving 95% coverage in 2019.ConclusionThe measles case-based surveillance system and vaccination program in the Greater Accra region showed an increasing level of performance towards Ghana’s elimination status. However, performance in laboratory testing of blood specimens was suboptimal. Authorities of Ghana’s health system should strengthen laboratory capacity for prompt diagnosis of measles.
Mapping topography and network of brain injury in patients with disorders of consciousness
Authors: Liyana Arachige Manoj , Seneviratne Udaya , John Nevin , Ma Henry , Phan Thanh G. 
Published: March 2023

BackgroundThere is a growing interest in the topography of brain regions associated with disorders of consciousness. This has caused increased research output, yielding many publications investigating the topic with varying methodologies. The objective of this study was to ascertain the topographical regions of the brain most frequently associated with disorders of consciousness.MethodsWe performed a cross-sectional text-mining analysis of disorders of consciousness studies. A text mining algorithm built in the Python programming language searched documents for anatomical brain terminology. We reviewed primary PubMed studies between January 1st 2000 to 8th February 2023 for the search query “Disorders of Consciousness.” The frequency of brain regions mentioned in these articles was recorded, ranked, then built into a graphical network. Subgroup analysis was performed by evaluating the impact on our results if analyses were based on abstracts, full-texts, or topic-modeled groups (non-negative matrix factorization was used to create subgroups of each collection based on their key topics). Brain terms were ranked by their frequency and concordance was measured between subgroups. Graphical analysis was performed to explore relationships between the anatomical regions mentioned. The PageRank algorithm (used by Google to list search results in order of relevance) was used to determine global importance of the regions.ResultsThe PubMed search yielded 24,944 abstracts and 3,780 full texts. The topic-modeled subgroups contained 2015 abstracts and 283 full texts. Text Mining across all document groups concordantly ranked the thalamus the highest (Savage score = 11.716), followed by the precuneus (Savage score = 4.983), hippocampus (Savage score = 4.483). Graphical analysis had 5 clusters with the thalamus once again having the highest PageRank score (PageRank = 0.0344).ConclusionThe thalamus, precuneus and cingulate cortex are strongly associated with disorders of consciousness, likely due to the roles they play in maintaining awareness and involvement in the default mode network, respectively. The findings also suggest that other areas of the brain like the cerebellum, cuneus, amygdala and hippocampus also share connections to consciousness should be further investigated.
Proposal for a Two-Tier Re-classification of Stage IV/M1 domain of Renal Cell Carcinoma into M1 (“Oligometastatic”) and M2 (“Polymetastatic”) subdomains: Analysis of the Registry for Metastatic Renal Cell Carcinoma (REMARCC)
Authors: Meagher Margaret F. , Mir Maria C. , Minervini Andrea , Kriegmair Maximilian , Heck Matthias , Porpiglia Francesco , Van Bruwaene Siska , Linares Estefania , Hevia Vital , D’Anna Maurizio , Veccia Alessandro , Roussel Eduard , Claps Francesco , Palumbo Carlotta , Marchioni Michele , Afari Jonathan , Saitta Cesare , Liu Franklin , Rubio Jose , Campi Riccardo , Mari Andrea , Amiel Thomas , Checcucci Enrico , Musquera Mireia , Guruli Georgi , Pavan Nicola , Albersen Maarten , Antonelli Alessandro , Klatte Tobias , Autorino Riccardo , McKay Rana R. , Derweesh Ithaar H. 
Published: March 2023

PurposeWe hypothesized that two-tier re-classification of the “M” (metastasis) domain of the Tumor-Node-Metastasis (TNM) staging of Renal Cell Carcinoma (RCC) may improve staging accuracy than the current monolithic classification, as advancements in the understanding of tumor biology have led to increased recognition of the heterogeneous potential of metastatic RCC (mRCC).MethodsMulticenter retrospective analysis of patients from the REMARCC (REgistry of MetAstatic RCC) database. Patients were stratified by number of metastases into two groups, M1 (≤3, “Oligometastatic”) and M2 (&gt;3, “Polymetastatic”). Primary outcome was overall survival (OS). Secondary outcomes were cancer-specific survival (CSS). Cox-regression and Kaplan-Meier (KMA) analysis were utilized for outcomes, and receiver operating characteristic analysis (ROC) was utilized to assess diagnostic accuracy compared to current “M” staging.Results429 patients were stratified into proposed M1 and M2 groups (M1 = 286/M2 = 143; median follow-up 19.2 months). Cox-regression revealed M2 classification as an independent risk factor for worsened all-cause mortality (HR=1.67, p=0.001) and cancer-specific mortality (HR=1.74, p&lt;0.001). Comparing M1-oligometastatic vs. M2-polymetastatic groups, KMA revealed significantly higher 5-year OS (36% vs. 21%, p&lt;0.001) and 5-year CSS (39% vs. 17%, p&lt;0.001). ROC analyses comparing OS and CSS, for M1/M2 reclassification versus unitary M designation currently in use demonstrated improved c-index for OS (M1/M2 0.635 vs. unitary M 0.500) and CSS (M1/M2 0.627 vs. unitary M 0.500).ConclusionSubclassification of Stage “M” domain of mRCC into two clinical substage categories based on metastatic burden corresponds to distinctive tumor groups whose oncological potential varies significantly and result in improved predictive capability compared to current staging.
How do serum lipid levels change and influence progression-free survival in epithelial ovarian cancer patients receiving bevacizumab treatment?
Authors: Huang Xiaoyu , Huang Yong , Li Ping 
Published: March 2023

BackgroundThis study aimed to investigate how serum lipid levels affect epithelial ovarian cancer (EOC) patients receiving bevacizumab treatment and to develop a model for predicting the patients’ prognosis.MethodsA total of 139 EOC patients receiving bevacizumab treatment were involved in this study. Statistical analysis was used to compare the median and average values of serum lipid level variables between the baseline and final follow-up. Additionally, a method based on machine learning was proposed to identify independent risk factors for estimating progression-free survival (PFS) in EOC patients receiving bevacizumab treatment. A PFS nomogram dividing the patients into low- and high-risk categories was created based on these independent prognostic variables. Finally, Kaplan–Meier curves and log-rank tests were utilized to perform survival analysis.ResultsAmong EOC patients involved in this study, statistical analysis of serum lipid level variables revealed a substantial increase in total cholesterol, triglycerides, apolipoprotein A1, and free fatty acids, and a significant decrease in apolipoprotein B from baseline to final follow-up. Our method identified FIGO stage, combined chemotherapy regimen, activated partial thromboplastin time, globulin, direct bilirubin, free fatty acids, blood urea nitrogen, high-density lipoprotein cholesterol, and triglycerides as risk factors. These risk factors were then included in our nomogram as independent predictors for EOC patients. PFS was substantially different between the low-risk group (total score &lt; 298) and the high-risk group (total score ≥ 298) according to Kaplan–Meier curves (P &lt; 0.05).ConclusionSerum lipid levels changed variously in EOC patients receiving bevacizumab treatment. A prediction model for PFS of EOC patients receiving bevacizumab treatment was constructed, and it can be beneficial in determining the prognosis, selecting a treatment plan, and monitoring these patients’ long-term care.
Nutritional impact of CFTR modulators in children with cystic fibrosis
Authors: Gaschignard Margaux , Beaufils Fabien , Lussac-Sorton Florian , Gallet Pauline , Clouzeau Haude , Menard Joris , Costanzo Aurélie , Nouard Lucie , Delhaes Laurence , Tetard Candice , Lamireau Thierry , Fayon Michael , Bui Stéphanie , Enaud Raphaël 
Published: March 2023

BackgroundNutritional status is a major prognostic factor for breathing and the survival of patients with cystic fibrosis (CF). Since 2012, the development of CFTR modulators has considerably transformed the outcome of this disease. Indeed, both lung function and body mass index are improved by CFTR modulators, such as Lumacaftor/Ivacaftor. However, few data exist regarding the outcome of nutritional intakes under Lumacaftor/Ivacaftor.MethodsWe conducted a prospective single-center study in children with CF treated with Lumacaftor/Ivacaftor to evaluate their nutritional intake before and after treatmentResultsThirty-four children were included in this study, with a median age of 12.4 years [11.9; 14.7]. There was no significant improvement in weight, height or BMI. Patients' total energy intake was not significantly changed with Lumacaftor/Ivacaftor, while carbohydrate intakes decreased significantly. We found that blood levels of vitamin E and Selenium were significantly increased under Lumacaftor/Ivacaftor, without a significant increase in supplementation. In patients with a BMI Z-score &lt; 0 at treatment initiation, there was a significant improvement in weight and BMI Z-score, while TEI and carbohydrate intakes were significantly lower.ConclusionWe showed that treatment with Lumacaftor/Ivacaftor improved the nutritional status of patients without necessarily being associated with an increase in nutritional intake. Although these data need to be confirmed in larger cohorts, they support the hypothesis that weight gain under modulators is multifactorial, and may be related to a decrease in energy expenditure or an improvement in absorption.
Relationship of epilepsy on the linguistic-cognitive profile of children with ASD: A systematic review of the literature
Authors: Cano-Villagrasa Alejandro , Moya-Faz Francisco José , López-Zamora Miguel 
Published: March 2023

IntroductionThe prevalence of comorbidity between epilepsy and Autism Spectrum Disorder (ASD) in the pediatric age increased significantly in recent years. The onset of epilepsy negatively influences the abilities of the user with ASD. Thus, epilepsy will be a disabling factor that will reduce the cognitive-linguistic skills of users with ASD. The main objective of this work is to review the current scientific literature and to compare the relationship of epilepsy on the development of cognitive and linguistic skills of children with ASD.MethodsIn this regard, a systematic search was carried out in the main sources (Medline, PubMed, WOS, ResearchGate and Google Scholar). 481 articles were identified, from which, after meeting the different inclusion and exclusion criteria, a total of 18 studies of relevance to the objectives of this work were selected.ResultsThe results reflect that, at a global level, epilepsy significantly influences the performance of cognitive- linguistic skills in people with ASD.DiscussionIn conclusion, epilepsy in the ASD population leads to a reduction in cognitive and linguistic abilities, which respond to the different types of epilepsy and their location, significantly impacting the quality of life and basic activities of daily living of the user with ASD.
A conceptual model for building program sustainability in public health settings: Learning from the implementation of the program sustainability action planning model and training curricula
Authors: Moreland-Russell Sarah , Jost Eliot , Gannon Jessica 
Published: March 2023

BackgroundThe emergence of implementation science has driven an increase in research examining the implementation of evidence-based programs and policies. However, there has been less attention through program sustainability. To achieve the full benefit of investment in program development and implementation, there must be an understanding of the factors that relate to sustainability; additionally, there is a need for a robust set of tools and trainings to support strategic long-term program sustainability. This paper presents results of our sustainability training intervention and a new conceptual model of sustainability. The proposed conceptual model builds upon the intervention design, further specifying the implementation strategy, strategy-mechanism linkages, and effect modifiers.MethodsThis research is part of the larger randomized control trial evaluating the effectiveness of the Program Sustainability Action Planning Model and Training Curricula. Specifically, this multimethod study establishes a conceptual model for program sustainability and related capacity-building interventions. The training intervention was delivered through workshops and technical assistance to 11 state tobacco control programs, principally entailing the development and implementation of a sustainability action plan. We utilize descriptive statistics and participant perspectives to evaluate the training intervention and propose an empirically-grounded conceptual model for sustainability capacity-building interventions in public health settings.ResultsParticipants found intervention components (workshop, workbook, instructor and resources) to be effective. Overall, participants found the intervention improved their ability to develop sustainability action plans and assess their program and partners. Throughout the study, program managers emphasized the importance of the workshop in providing direction for their sustainability work and the value of robust, ongoing technical assistance. Program managers identified several factors that interfered with intervention reception including staff turnover, competing priorities, partnership challenges, and the COVID-19 pandemic.ConclusionThe present study documents the development and implementation of a novel Program Sustainability Action Planning Model and Training Curricula, one of the first interventions designed to improve program sustainability. In addition, we present an empirically-grounded conceptual model for program sustainability. Considering the paucity of research in this understudied and undefined topic area, this is an important contribution that can serve as a framework for similar intervention designs and implementation efforts.
Clinical Trail Registration: ClinicalTrails.gov identification number is NCT03598114.
Understanding farmer knowledge and site factors in relation to soil-borne pests and pathogens to support agroecological intensification of smallholder bean production systems
Authors: Ngoya Zuwena J. , Mkindi Angela G. , Vanek Steven J. , Ndakidemi Patrick A. , Stevenson Philip C. , Belmain Steven R. 
Published: March 2023

IntroductionPests and diseases limit common bean (Phaseolus vulgaris) production in intensifying smallholder farming systems of sub-Saharan Africa. Soil-borne pests and diseases (SPD) are particularly challenging for farmers to distinguish and manage in cropping systems that vary in terms of soils, farmer knowledge, and management factors. Few studies have examined soil drivers of SPD in smallholder systems, integrated with farmers' perceptions and management practices.MethodsIn Kilimanjaro, Tanzania, we assessed farmer knowledge and SPD management for common bean alongside soil type and soil quality. Focus group discussions and field survey findings including farmer observations and soil nutrient balances were integrated with soil analyses of farmers' fields. Multiple correspondence analysis (MCA) and principal component analysis (PCA) assessed relationships among farmer demographics, pests and diseases, soil characteristics, and management practices.Results and discussionSurveys revealed that 100% of farmers knew of the bean foliage beetle (Ootheca bennigseni) but few recognized the soilborne pest Ophiomyia spp. or bean fly despite it being more destructive. About a third of farmers knew of root rot diseases caused by Pythium spp. and Fusarium spp. Synthetic pesticides were used by 72% of farmers to control pests, while about half that (37%) used pesticidal plants, particularly Tephrosia vogelii extracts sprayed on foliage. Regarding SPD, 90% of farmers reported that their management practices were ineffective. Meanwhile, synthetic fertilizers were used by nearly all farmers in beans intercropped with maize (Zea mays), whilst very few farmers used manure or compost. Soil available phosphorus was lowbut showed a balance between inputs and outputs regardless of whether fields were owned. Field nitrogen balances were more negative when fields were owned by farmers. An MCA showed that older farmers employed a greater number of pest control practices. The PCA showed that field variability was dominated by soil organic matter, elevation, and soil pH. Higher organic matter levels were also associated with less stunting and wilting of beans observed by farmers. Our results suggest that research and farmer learning about SPD ecology are key gaps, alongside recycling of organic residues to soils. Cost-effective and sustainable practices to manage bean SPDs for smallholders are also needed.
Применение средств оздоровительной аэробики в процессе эстетического воспитания студенток
Authors: Kapustina T. V. , Alpatova А. А , Pluzhnikova Yu.Yu. 
Published: March 2023

Цель: определить роль и влияние средств оздоровительной аэробики в процессе эстетического воспитания студенток. Материал. Для проведения исследования были набраны группы студенток: основная и контрольная по 30 человек. Перед началом исследования с помощью анкетирования была выявлена самооценка студенток относительно воздействия аэробики на их психоэмоциональное состояние. Результаты. На основе анализа литературы установлено, что занятия аэробикой развивает творческие способности и имеет целенаправленное воздействие на: эстетическое воспроизведение, образование мышления, воображения, владение способами деятельности, эмоциональных отношений к объектам эстетического характера. Современная аэробика – это очень динамичная структура, которая постоянно пополняется арсеналом используемых средств и методов. Появляются все новые и новые виды занятий аэробикой с использованием различных предметов, тренажеров и других устройств. Современная оздоровительная аэробика – один из массовых видов физической культуры, привлекательной стороной которого является не только доступность двигательных действий, но и их высокая оздоровительная и эстетическая направленность. Показано положительное влияние оздоровительной аэробики под музыкальное сопровождение на эстетическое развитие студенток основной группы. По всем критериям оценки уровня эстетического восприятия была выявлена положительная динамика. Общее психоэмоциональное состояние и интерес к занятиям улучшились в ходе исследования. У студенток, которые на протяжении всего эксперимента занимались аэробикой, самочувствие и настроение улучшилось, мотивация к занятиям повысилась, а активность показала максимальный результат из перечисленного выше. Выводы. Аэробика может быть рекомендована как вид физической деятельности для эстетического воспитания студенток.
Успішність виступів збірних команд з футболу 7х7 (спортсмени-інваліди з наслідками ДЦП та іншими неврологічними захворюваннями) на Паралімпійських іграх
Authors: Sobko I.M. , Seryi A.V. , Grinchenko I.B. , Yurchenko P.O. 
Published: March 2023

Мета роботи – теоретично та експериментально обґрунтувати вплив вікових та техніко-тактичних показників на успішність виступів головних лідерів з футболу ДЦП на Паралімпійських іграх. Матеріал і методи. Учасники. Збірні команди України, Росії, Бразилії, Ірану з футболу з ДЦП у кількості 12 чоловік, вік 21-39 років. Хід дослідження. Був проаналізований розподіл місць ведучих футбольних команд Світу з футболу спортсменів з ДЦП на Паралімпійських іграх за останні 15 років. Зафіксовані вікові та техніко-тактичні показники чоловічих збірних команд з футболу України, Росії, Бразилії, Ірану. Результати. Показано, що в четвірку найсильніших чоловічих футбольних команд світу з ДЦП входять збірні України, Росії, Бразилії, Ірану. Складено моделі множинної лінійної регресії між місцем, яке займає команда на Паралімпійських іграх за останні 15 років, та віковими і техніко-тактичними показниками. Обрана модель множинної регресії представлена перемінними кількість гравців 30-40 років та кількість забитих м’ячів. Виявлено, успішність виступів збірних команд з інвалідному спорті на головних змаганнях залежить від віку спортсменів та їх техніко-тактичної підготовленості. Переважна більшість досвідчених гравців у складі збірної дає змогу команді показати кращий результат на головних змаганнях ніж суперники. Висновки. Виявлено, успішність виступів збірних команд з інвалідному спорті на головних змаганнях залежить від віку спортсменів та їх техніко-тактичної підготовленості. Рекомендовано врахування віку спортсменів з обмеженими можливостями на всіх етапах чотирирічного циклу підготовки. Адже у спортсменів даної категорії з віковими даними багато в чому пов'язані темпи зростання спортивної майстерності При комплектуванні складу збірної команди тренерам необхідно звертати особливу увагу на гравців 30-40 років.