bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic resonance imaging for treatment response evaluation and prognostication of hepatocellular carcinoma after thermal ablation
Authors: Zhang Yun , Wei Hong , Song Bin 
Published: May 2023

Abstract
Hepatocellular carcinoma (HCC) accounts for the vast majority of primary liver cancer and constitutes a major global health challenge. Tumor ablation with either radiofrequency ablation (RFA) or microwave ablation (MWA) is recommended as a curative-intent treatment for early-stage HCC. Given the widespread use of thermal ablation in routine clinical practice, accurate evaluation of treatment response and patient outcomes has become crucial in optimizing individualized management strategies. Noninvasive imaging occupies the central role in the routine management of patients with HCC. Magnetic resonance imaging (MRI) could provide full wealth of information with respect to tumor morphology, hemodynamics, function and metabolism. With accumulation of liver MR imaging data, radiomics analysis has been increasingly applied to capture tumor heterogeneity and provide prognostication by extracting high-throughput quantitative imaging features from digital medical images. Emerging evidence suggests the potential role of several qualitative, quantitative and radiomic MRI features in prediction of treatment response and patient prognosis after ablation of HCC. Understanding the advancements of MRI in the evaluation of ablated HCCs may facilitate optimal patient care and improved outcomes. This review provides an overview of the emerging role of MRI in treatment response evaluation and prognostication of HCC patients undergoing ablation.

Clinical relevance statement
MRI-based parameters can help predict treatment response and patient prognosis after HCC ablation and thus guide treatment planning.

Key points

ECA-MRI provides morphological and hemodynamic assessment of ablated HCC.

EOB-MRI provides more information for tumor response prediction after ablation.

DWI improve the characterization of HCC and optimize treatment decision.

Radiomics analysis enables characterization of tumor heterogeneity guidance of clinical
decision-making.

Further studies with multiple radiologists and sufficient follow-up period are needed.

Graphical abstract
Urinary neutrophil gelatinase-associated lipocalin and plasma IL-6 in discontinuation of continuous venovenous hemodiafiltration for severe acute kidney injury: a multicenter prospective observational study
Authors: Komaru Yohei , Oguchi Moe , Sadahiro Tomohito , Nakada Taka-aki , Hattori Noriyuki , Moriguchi Takeshi , Goto Junko , Shiga Hidetoshi , Kikuchi Yoshihiko , Negi Shigeo , Shigematsu Takashi , Kuriyama Naohide , Nakamura Tomoyuki , Doi Kent 
Published: May 2023

AbstractBackgroundPatients with severe acute kidney injury (AKI) who require continuous venovenous hemodiafiltration (CVVHDF) in intensive care unit (ICU) are at high mortality risk. Little is known about clinical biomarkers for risk prediction, optimal initiation, and optimal discontinuation of CVVHDF.MethodsThis prospective observational study was conducted in seven university-affiliated ICUs. For urinary neutrophil gelatinase-associated lipocalin (NGAL) and plasma IL-6 measurements, samples were collected at initiation, 24 h, 48 h after, and CVVHDF discontinuation in adult patients with severe AKI. The outcomes were deaths during CVVHDF and CVVHDF dependence.ResultsA total number of 133 patients were included. Twenty-eight patients died without CVVHDF discontinuation (CVVHDF nonsurvivors). Urinary NGAL and plasma IL-6 at the CVVHDF initiation were significantly higher in CVVHDF nonsurvivors than in survivors. Among 105 CVVHDF survivors, 70 patients were free from renal replacement therapy (RRT) or death in the next 7 days after discontinuation (success group), whereas 35 patients died or needed RRT again (failure group). Urinary NGAL at CVVHDF discontinuation was significantly lower in the success group (93.8 ng/ml vs. 999 ng/ml,p < 0.01), whereas no significant difference was observed in plasma IL-6 between the groups. Temporal elevations of urinary NGAL levels during the first 48 h since CVVHDF initiation were observed in CVVHDF nonsurvivors and those who failed in CVVHDF discontinuation.ConclusionsUrinary NGAL at CVVHDF initiation and discontinuation was associated with mortality and RRT dependence, respectively. The serial changes of urinary NGAL might also help predict the prognosis of patients with AKI on CVVHDF.Graphical Abstract
Variational Autoencoders for chord sequence generation conditioned on Western harmonic music complexity
Authors: Comanducci Luca , Gioiosa Davide , Zanoni Massimiliano , Antonacci Fabio , Sarti Augusto 
Published: May 2023

AbstractIn recent years, the adoption of deep learning techniques has allowed to obtain major breakthroughs in the automatic music generation research field, sparking a renewed interest in generative music. A great deal of work has focused on the possibility of conditioning the generation process in order to be able to create music according to human-understandable parameters. In this paper, we propose a technique for generating chord progressions conditioned on harmonic complexity, as grounded in the Western music theory. More specifically, we consider a pre-existing dataset annotated with the related complexity values and we train two variations of Variational Autoencoders (VAE), namely a Conditional-VAE (CVAE) and a Regressor-based VAE (RVAE), in order to condition the latent space depending on the complexity. Through a listening test, we analyze the effectiveness of the proposed techniques.
Factors affecting “employees’ creativity”: the mediating role of intrinsic motivation
Authors: Yesuf Yohannes Mekonnen , Getahun Demis Alamirew , Debas Asemamaw Tilahun 
Published: May 2023

AbstractThis article examines a particular set of influences on the creativity of individual researchers at an Ethiopian agricultural research institute. One set of influences is "work orientations," and the others are "domain-relevant skills" and "creativity-relevant processes." The study posits that another important influence, intrinsic motivation, is a mediating influence between these factors and creativity. The study moves beyond past research by examining the influences together in a structural equation model. The data were collected from 307 researchers working with an agricultural research institute in different centers in Ethiopia. Partial Least Squares (PLS) path modeling, SmartPLS3, was used to empirically test the proposed hypotheses. The findings suggested the significantly positive direct effects of creativity-relevant processes, career orientation, and calling orientation on employees’ creativity. Moreover, the results of mediating effects showed significant indirect effects of domain-relevant skills, creativity-relevant processes, career orientation, and job orientation via intrinsic motivation on enhancing employees’ creativity. However, the results did not confirm the direct effects of domain-relevant skills and job orientation on employees’ creativity. In addition, the results did not confirm the hypothesis that the mediator, intrinsic motivation, had a statistically significant effect on the relationship between job orientation and employees’ creativity. Finally, for managers and decision-makers who prioritize employees’ creativity, these findings will deepen their understanding of the holistic role of intrinsic motivation in nurturing employees’ creativity.
Cuproptosis-Related Ferroptosis genes for Predicting Prognosis in kidney renal clear cell carcinoma
Authors: Luo Gang , Wang Lini , Zheng Ziyu , Gao Baobao , Lei Chong 
Published: May 2023

AbstractKidney renal clear cell carcinoma (KIRC) is a main subtype of kidney cancers. Cuproptosis and ferroptosis are correlated with immune infiltration and prognosis in tumors. However, the role of Cuproptosis-related Ferroptosis genes (CRFGs) in KIRC has rarely been fully understood. Therefore, we constructed a prognostic signature based on different expression of CRFGs in KIRC. All raw data of this study were extracted from public TCGA datasets. Cuproptosis and Ferroptosis genes were collected from the previous research. Finally, a total of 36 significantly different CRFGs were identified from TCGA–KIRC cohort. Six-gene signature (TRIB3, SLC2A3, PML, CD44, CDKN2A and MIOX) was identified by LASSO Cox regression based on the significantly different CRFGs. The CRFGs signature was correlated with worse overall survival and the AUC was 0.750. Functional enrichment indicated that CRFGs were mainly enriched in metabolism, drug resistance, tumor immunity pathways. Besides, the IC50 and immune checkpoint differentially expressed between different groups. The proposed 6-CRFGs signature is a promising biomarker to predict clinical outcomes and therapeutic responses for KIRC patient.
Failure Mechanisms and Rehabilitation Scenarios for Concrete Hydroelectric Facilities Affected by Alkali–Aggregate Reaction
Authors: Ftima Mahdi Ben , Yildiz Emre 
Published: May 2023

AbstractThis work focuses on the failure mechanisms of concrete hydroelectric facilities affected by alkali–aggregate reaction (AAR). Identification of potential failure mechanisms is based on an original “top-down approach” using an AAR pushover analysis with multi-physics numerical simulation of a representative hydroelectric facility. Different global rehabilitation scenarios based on slot-cutting and grouting techniques are discussed and compared, using different performance metrics. A new quantitative performance metric, specifically developed for the nonlinear sophisticated analysis tool and considering the volumetric cracking caused by AAR is also suggested. Based on comparison results, a combination of grouting after a partial slot-cutting in the neighborhood of the discontinuities, appears to provide the best compromise in terms of stress relief and extent of cracking. New AAR benchmark problems, issued from the top-down approach, are also suggested for the first time in the literature.
High-risk spatiotemporal patterns of cutaneous leishmaniasis: a nationwide study in Iran from 2011 to 2020
Authors: Firouraghi Neda , Bergquist Robert , Fatima Munazza , Mohammadi Alireza , Hamer Davidson H. , Shirzadi Mohammad Reza , Kiani Behzad 
Published: May 2023

AbstractBackgroundCutaneous leishmaniasis (CL) is a wide-reaching infection of major public health concern. Iran is one of the six most endemic countries in the world. This study aims to provide a spatiotemporal visualization of CL cases in Iran at the county level from 2011 to 2020, detecting high-risk zones, while also noting the movement of high-risk clusters.MethodsOn the basis of clinical observations and parasitological tests, data of 154,378 diagnosed patients were obtained from the Iran Ministry of Health and Medical Education. Utilizing spatial scan statistics, we investigated the disease’s purely temporal, purely spatial, spatial variation in temporal trends and spatiotemporal patterns. AtP = 0.05 level, the null hypothesis was rejected in every instance.ResultsIn general, the number of new CL cases decreased over the course of the 9-year research period. From 2011 to 2020, a regular seasonal pattern, with peaks in the fall and troughs in the spring, was found. The period of September–February of 2014–2015 was found to hold the highest risk in terms of CL incidence rate in the whole country [relative risk (RR) = 2.24,P < 0.001)]. In terms of location, six significant high-risk CL clusters covering 40.6% of the total area of the country were observed, with theRRranging from 1.87 to 9.69. In addition, spatial variation in the temporal trend analysis found 11 clusters as potential high-risk areas that highlighted certain regions with an increasing tendency. Finally, five space-time clusters were found. The geographical displacement and spread of the disease followed a moving pattern over the 9-year study period affecting many regions of the country.ConclusionsOur study has revealed significant regional, temporal, and spatiotemporal patterns of CL distribution in Iran. Over the years, there have been multiple shifts in spatiotemporal clusters, encompassing many different parts of the country from 2011 to 2020. The results reveal the formation of clusters across counties that cover certain parts of provinces, indicating the importance of conducting spatiotemporal analyses at the county level for studies that encompass entire countries. Such analyses, at a finer geographical scale, such as county level, might provide more precise results than analyses at the scale of the province.Graphical Abstract
The association of care burden with motivation of vaccine acceptance among caregivers of stroke patients during the COVID-19 pandemic: mediating roles of problematic social media use, worry, and fear
Authors: Kukreti Shikha , Strong Carol , Chen Jung-Sheng , Chen Yi-Jung , Griffiths Mark D. , Hsieh Meng-Tsang , Lin Chung-Ying 
Published: May 2023

Abstract
Background
The aim of the present study was to investigate the relationship between care burden and motivation of COVID-19 vaccine acceptance among caregivers of patients who have experienced a stroke and to explore the mediating roles of social media use, fear of COVID-19, and worries about infection in this relationship.

Methods
A cross-sectional survey study with 172 caregivers of patients who had experienced a stroke took part in a Taiwan community hospital. All participants completed the Zarit Burden Interview, Bergen Social Media Addiction Scale, Worry of Infection Scale, Fear of COVID-19 Scale, and Motors of COVID-19 Vaccine Acceptance Scale. Multiple linear regression model was applied to construct and explain the association among the variables. Hayes Process Macro (Models 4 and 6) was used to explain the mediation effects.

Results
The proposed model significantly explained the direct association of care burden with motivation of COVID-19 vaccine acceptance. Despite the increased care burden associated with decreased vaccine acceptance, problematic social media use positively mediated this association. Moreover, problematic social media use had sequential mediating effects together with worry of infection or fear of COVID-19 in the association between care burden and motivation of vaccine acceptance. Care burden was associated with motivation of vaccine acceptance through problematic social media use followed by worry of infection.

Conclusions
Increased care burden among caregivers of patients who have experienced a stroke may lead to lower COVID-19 vaccines acceptance. Moreover, problematic social media use was positively associated with their motivation to get COVID-19 vaccinated. Therefore, health experts and practitioners should actively disseminate accurate and trustworthy factual information regarding COVID-19, while taking care of the psychological problems among caregivers of patients who have experienced a stroke.
The atypical hues of the Santa Cruz blue-and-white cargo: non-invasive analysis of glaze defects and color variations in mid-Ming porcelain
Authors: Hsieh Ellen , Fischer Christian , C. Orillaneda Bobby 
Published: May 2023

Abstract
Color variations and sometimes the frosted appearance of Chinese blue-and-white porcelain produced in folk kilns and recovered in underwater archaeological contexts are usually reported without further investigation. This study focuses on the causes responsible for the appearance of the glaze and blue decorations of late fifteenth-century blue-and-white porcelain from the Santa Cruz, one of the most important mid-Ming shipwrecks discovered in Asian waters. Besides detailed visual observations, chemical composition and colorimetric data were collected on a set of similarly shaped plates showing significant differences in the aspect of the glaze and tones and shades of the blue color. Results from portable X-ray fluorescence (pXRF) analysis confirmed the Jingdezhen origin of the ware and the use of domestic asbolane ores for the Co-based blue pigment. Visual and microstructural analysis has shown that the degree of opacity of the glaze is primarily linked to the crystallization of anorthite, which in some cases has pushed the pigment layer towards the surface, contributing to the development of white-brownish weathering spots. The colorimetric data acquired with fiber optics reflectance spectroscopy (FORS) allowed us to quantify chromaticity parameters and confirm the visual perception of a ‘not-so-blue’ color of the decoration. Without excluding a possible contribution of the underwater environment, the observed variations can be mainly attributed to the ware’s production and more specifically to pigment characteristics, manufacturing processes, and firing conditions even though the connection with these factors is not straightforward and prompts further research and broader discussions. From a historical perspective, it is suggested that the atypical hues are correlated with the progressive switch from foreign to domestic pigment sources during the Chenghua period (1465–87 CE) and the subsequent technological adaptations required by an ever-increasing demand for Chinese blue-and-white porcelain at the turn of the sixteenth century.
The effect of maxillary molar distalization with clear aligner: a 4D finite-element study with staging simulation
Authors: Mao Bochun , Tian Yajing , Xiao Yujia , Li Jing , Zhou Yanheng 
Published: May 2023

Abstract
Introduction
Long-term simulation of tooth movement is crucial for clear aligner (CA) treatment. This study aimed to investigate the effect of maxillary molar distalization with CA via an automatic staging simulation.

Method
A finite-element method (FEM) model of maxillary dentition, periodontal ligaments, attachments, and corresponding CA was established, and a prescribed 2-mm distalization with 0.1 mm each step of the second molar was simulated. The long-term tooth movement under orthodontic force was simulated with an iterative computation method. The morphologic changes of CA during staging were simulated with the thermal expansion method.

Results
Twenty steps of molar distalization were simulated. Significant distal tilting of the second molar was revealed, along with the proclination of anterior teeth, which caused the ‘reversed bow effect’. For the second molar, 4.63°distal tilting at the 20th step was revealed. The intrusion of the incisors and the second molar were 0.43 mm, 0.39 mm, and 0.45 mm, respectively, at step 20. All the anterior teeth showed a proclination of approximately 1.41°–2.01° at the 20th step. The expression rate of the designed distalization of the second molar was relatively low (approximately 68%) compared to the high efficacy of interdental space opening between molars with CA (approximately 89%).

Conclusion
A novel method of simulating long-term molar distalization with CA with FEM was developed. The FEM results suggested distal tilting of the second molar and the proclination of anterior teeth during the molar distalization.
24-h Movement Guidelines and Overweight and Obesity Indicators in Toddlers, Children and Adolescents: A Systematic Review and Meta-Analysis
Authors: Marques Adilson , Ramirez-Campillo Rodrigo , Gouveia Élvio R. , Ferrari Gérson , Tesler Riki , Marconcin Priscila , Loureiro Vânia , Peralta Miguel , Sarmento Hugo 
Published: May 2023

Abstract
Background
Engaging in physical activity increases energy expenditure, reducing total body fat. Time spent in sedentary behaviours is associated with overweight and obesity, and adequate sleep duration is associated with improved body composition. This systematic review aimed to analyse the relationship between compliance with the 24-h movement guidelines and obesity indicators in toddlers, children and adolescents.

Methods
A systematic review and meta-analysis was conducted. PubMed, Web of Science and Scopus were searched from inception to December 2021. Cross-sectional and prospective studies that analysed the relationship between 24-h movement guidelines and overweight and obesity written in English, French, Portuguese or Spanish were included. PROSPERO registration number is CRD42022298316.

Results
The associations between meeting the 24-h movement guidelines and standardised body mass index were null in the two studies for toddlers. Seven studies analysed the relationship between compliance with the 24-h movement guidelines and overweight and obesity among preschool children. Of these seven studies, six found no association between compliance with 24-h movement guidelines and body composition. Among children and adolescents, 15 articles were analysed. Of these 15 studies, in seven, it was found that children and adolescents who meet the 24-h movement guidelines were more likely to have lower risks of overweight and obesity. The meta-analysis yielded a pooled OR = 0.80 (95% CI = 0.68 to 0.95, p = 0.012, I2 = 70.5%) in favour of compliant participants. Regarding participants’ age groups, compliance with 24-h movement guidelines seems to exert greater benefits on overweight and obesity indicators among children-adolescents (OR = 0.62, p = 0.008) compared to participants at preschool (OR = 1.00, p = 0.931) and toddlers (OR = 0.91, p = 0.853).

Conclusion
Most included studies have not observed a significant relationship between compliance with the 24-h movement guidelines and overweight and obesity in toddlers, children and adolescents.
Feasibility and preliminary efficacy of structured programming and a parent intervention to mitigate accelerated summer BMI gain: a pilot study
Authors: Weaver R. G. , Armstrong B. , Adams E. , Beets M. W. , White J. , Flory K. , Wilson D. , McLain A. , Tennie B. 
Published: May 2023

AbstractBackgroundThis study assessed the initial feasibility and preliminary efficacy of providing children a free summer day camp and a parent intervention to improve self-regulation and mitigate accelerated summer BMI gain.MethodsThis pilot 2x2 factorial randomized control trial used a mixed-methods design to evaluate providing children a free summer day camp (SCV), a parent intervention (PI), and the combination of these two strategies (SCV+PI) to mitigate accelerated summer body mass index (BMI) gain. Progression criteria for feasibility and efficacy were assessed to determine if a full-scale trial was warranted. Feasibility criteria included recruitment capability (≥80 participants recruited) retention (≥70% participants retained), compliance (≥80% of participants attending the summer program with children attending ≥60% of program days, and ≥80% of participants completing goal setting calls with ≥60% of weeks syncing their child’s Fitbit), and treatment fidelity (≥80% of summer program days delivered for ≥9 h/day, and ≥80% of participant texts delivered). Efficacy criteria were assessed via achieving a clinically meaningful impact on zBMI (i.e., ≥0.15). Changes in BMI were estimated using intent-to-treat and post hoc dose-response analyses via multilevel mixed-effects regressions.ResultsFor recruitment, capability and retention progression criteria were met with a total of 89 families participating and 24 participants randomized to the PI group, 21 randomized to the SCV group, 23 randomized to the SCV+PI group, and 21 randomized to the control. However, fidelity and compliance progression criteria were not achieved due to COVID-19 and lack of transportation. Progression criteria for efficacy was also not achieved as intent-to-treat analyses did not show changes in BMI gain that were clinically meaningful. Post hoc dose-response analyses showed that for each day (0 to 29) of summer programming children attended they gained −0.009 (95CI= −0.018, −0.001) less in BMIzscore.ConclusionsEngagement in both the SCV and PI was not ideal due to COVID-19 and lack of transportation. Providing children with structured summer programming to mitigate accelerated summer BMI gain may be an effective strategy. However, because feasibility and efficacy progression criteria were not met, a larger trial is not warranted until further pilot work is completed to ensure children attend the programming.Trial registrationThe trial reported herein was prospectively registered at ClinicalTrials.gov. Trial #: NCT04608188.