bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diseño del sistema automatizado para la generación y gestión de documentos en la etapa precontractual de compras públicas para instituciones públicas en el Ecuador
Authors: De la Rosa-Martín Tonysé , León-González Jorge Luis 
Published: January 2023

La presente investigación se centra en el Diseño de un sistema para la generación de documentos en la etapa preparatoria y precontractual de compras públicas para las instituciones públicas del Ecuador. Se realizó una investigación completa de las falencias en los procesos actuales que se manejan para las compras públicas, se determinó realizar distintos módulos para la generación de documentos, además de módulos de administración. Este sistema fue desarrollado en un ambiente web como lenguaje principal PHP, además se utilizaron dos frameworks: Laravel y Bootstrap, también se utilizará la librería de JQuery, como almacenamiento de los datos se utilizó el gestor de base de datos MariaDB.Este Sistemas se apoya en la metodología de desarrollo de Software RUP (Rational Unified Process), se utilizó el lenguaje unificado de modelado UML, estas son herramientas necesarias en el análisis y diseño de sistemas POO (Programación orientada a objetos). El sistema resuelve el problema de la gestión de las compras públicas para instituciones inscritas al gobierno en el Ecuador.
Palabras clave:
Compras, oferta pública, gobierno, institucionalidad.

ABSTRACT
The present investigation focuses on the Design of a system for the generation of documents in the pre-contractual and pre-contractual stage of public purchases for public institutions in Ecuador. A complete investigation of the shortcomings in the current processes that are managed for public purchases was carried out, it was determined to carry out different modules for the generation of documents, in addition to administration modules. This system was developed in a web environment as the main language PHP, in addition two frameworks were used: Laravel and Bootstrap, the JQuery library will also be used, as data storage the MariaDB database manager was used. This Systems is based on the RUP (Rational Unified Process) Software development methodology, the unified modeling language UML was used, these are necessary tools in the analysis and design of OOP (Object Oriented Programming) systems. The system solves the problem of managing public purchases for institutions registered with the government in Ecuador.
Keywords:
Purchases, public offering, government, institutionality.
Hormones et perturbateurs endocriniens : quelles similitudes ? Quelles différences ? / Hormones and endocrine disruptors: what similarities? What are the differences?
Authors: Combarnous Yves 
Published: January 2023

Endocrine disruptor compounds (EDC) are synthetic or natural compounds in the environment promoting unwanted modifications of endocrine homeostasis (regulated by endogeneous hormones) in human and/or in animals. In the present note, we describe similarities and differences between hormones and EDCs’ mechanisms of action, in order to decipher more precisely the structural and biological characteristics of the latters and to better appreciate their risks, and not only their hazards.
De obras que se autodestruyen, de aporías estéticas y de intentos variados de despistar. Una interpretación de la obra de Banksy
Authors: Murcia Serrano Inmaculada 
Published: January 2023

En una subasta de Sotheby´s del año 2018, una versión en óleo de la obra del artista callejero anónimo que firma con el nombre de Banksy se autotrituró parcialmente en el momento en el que era pujada al mejor postor. En el acto propiciado por Banksy a se ponían en juego asuntos teóricos de gran calado. Por un lado, el aprovechamiento del tópico teórico de la agencia material, en este caso, encarnada en un objeto artístico que “cobró vida” en el momento de la subasta; en segundo lugar, el acto en sí de la autodestrucción de la obra, que entronca, aunque particularizándolo, con los numerosos gestos iconoclastas que durante siglos han estado asociados con el contexto del arte; en tercer lugar, la importancia del fin perseguido por Banksy con esta acción, un fin no exento de aporías, contradicciones y fascinantes paradojas que terminan en la interesante reflexión en torno a la institucionalización y la comercialización de las obras de arte. Todos ellos entroncan con el espíritu con el que nació el arte conceptual.
Prevalensi dan Faktor-faktor yang Berhubungan dengan Simtom Depresi pada Penduduk di Indonesia (Analisis Data IFLS5 Tahun 2014-2015
Authors: Simanjuntak Tri Damayanti , Noveyani Adistha Eka , Kinanthi Citra Anggun 
Published: January 2023

Berdasarkan data WHO, secara global prevalensi jumlah orang yang hidup dengan depresi diperkirakan mengalami peningkatan sebesar 18,4% antara tahun 2005 dan 2015. Depresi merupakan fenomena yang kompleks, karena diduga beberapa simtom depresi memiliki faktor risiko yang berbeda. Beberapa penelitian sebelumnya tentang depresi fokus pada kelompok tertentu, misalnya lansia, pelajar, maupun ibu setelah melahirkan yang dilakukan pada cakupan wilayah yang cukup kecil. Penelitian ini bertujuan meneliti prevalensi dan faktor-faktor yang berhubungan dengan simtom depresi di Indonesia. Desain penelitian ini adalah cross-sectional dan menggunakan data sekunder, yaitu survei nasional Indonesia Family Life Survey ke-5 (IFLS5). Teknik sampling yang digunakan adalah teknik stratified random sampling dimana ditemukan sebanyak 27.622 orang yang memenuhi kriterian inklusi dan eksklusi. Penelitian ini menunjukkan prevalensi simtom depresi pada populasi Indonesia pada tahun 2014 - 2015 adalah 23,14%. Dari analisis multivariat dengan cox regression ditemukan bahwa kelompok usia 18-25 (PR=1,64, 95% CI 1,52-1,77), perempuan (PR=1,39, 95% CI 1,29-1,49), berpisah/cerai (PR=1,31, 95% CI 1,20-1,42), merokok (PR=1,28, 95% CI 1,19-1,38), aktivitas berat (PR=1,61, 95% CI 1,52-1,71), hipertensi (PR=1,32, 95% CI 1,24 - 1,41), dan kanker (PR=1,31, 95% CI 1,53-1,63) berhubungan dengan simtom depresi. Studi ini menunjukkan bahwa risiko depresi dapat diturunkan dengan mengendalikan faktor risiko, seperti untuk tidak merokok, aktivitas fisik disesuaikan dengan kebutuhan, cegah hipertensi, dan cegah kanker. Dimasa mendatang diperlukan penelitian lebih lanjut terkait faktor sosial dengan depresi dengan desain studi yang lebih baik untuk menunjukkan hubungan kausalitas.
Soil Acidity and its Distribution in Laterite Soils of Northern Kerala: A Descriptive Analysis
Authors: Sreelakshmi M. M. , Aparna B. , B. Rani 
Published: January 2023

Soil acidity is one of the major constraints of crop production in tropical soils. A study was conducted to examine different forms of soil acidity, contribution of each fraction to total acidity and distribution of exchangeable Al+3, exchangeable H+ detrital laterite rice wetlands of Kerala. Among the series, the Kalikkadavu series reported the highest exchangeable acidity with a mean of 1.66 ± 0.23 meq/100g at a depth of 0-15 cm. Soils from Angadipuram series showed high values for exchangeable hydrogen with a mean of 0.71 ± 0.87 meq/100g and a range of 0.2- 3 meq/100g. Kalikkadavu series reported a high value for exchangeable hydrogen with a mean value of 1.29 ± 0.23 meq/100 g. Regarding potential acidity, Nanminda series reported the highest with a mean value of 40.2 meq/100g. Descriptive statistics of pH dependent acidity data revealed highest acidity for Nanminda series in surface layer with a mean value of 39.27 ± 1.77 meq/100g while in subsurface soils, Arathil series has reported the highest with a mean value of 32.21 ± 3.28 meq/100g. From the paired t-test analysis, significant variations of potential acidity and pH-dependent acidity were observed across surface and subsurface while exchangeable acidity, exchangeable Al+3, exchangeable H+ have shown non-significant variation.Hence, we recommend a proper soil management system that lowers the surface and subsoil acidity in low-pH soil. Again, for best effects in terms of biomass production and economic crop yields, amelioration of soil acidity should be followed by optimum plant nutrient inputs.
Effect of Organic and Liquid Manures on Yield, Yield Attributes and Economic of Urdbean
Authors: Ram Verma Singh , Yadav S. S. , Hritik Srivastava , Umesh Singh Kumar , Yashvant Singh , Shivendra Mishra Kumar 
Published: January 2023

A field experiment was carried out in 2020 kharif season, on loamy sand soil at the S.K.N. College of Agriculture's Agronomy Farm in Jobner (Rajasthan). It included two foliar sprays of each of four liquid manures (control, 100% RDP panchgavya @ 5%, 100% RDP vermiwash @ 10%, and 100% RDP cow urine @ 5%), totaling sixteen treatment combinations. It included four treatments of organic manures (control, 100% RDP through FYM, through vermicompost, and through poultry manure) and two foliar sprays of each of four liquid manures. Three replications of the experiment were set up using a Randomized Block Design. 'Krishna' variety of urdbean was sown as on July 13, 2020, a test crop with a 30-cm row spacing. The results showed that two foliar sprays of 5% panchgavya were the most effective liquid manure treatment in raising the maximum seed production (942 kg/ha), straw yield (2,121 kg/ha), and biological yield (3,063 kg/ha) of urdbean. The highest levels of nitrogen, phosphorous, and potassium were found in seed and straw under this liquid manure treatment, which was comparable to two foliar sprays of 10% vermiwash. However, applying 100% RDP through FYM was the most lucrative strategy, for obtaining higher yield, net returns of '36,314/ha and a B:C ratio of 2.68. Foliar spraying with 5% panchgavya also generated an extra 36,798/ha in net returns over the control, which had the highest B:C ratio of 2.37.
The Association between Neutrophil to Lymphocyte Ratio and Demographic and Clinical Data in Diabetic Peripheral Neuropathy Patients in Jeddah
Authors: Magadmi Rania , Bakedo Leyan , Abid Deema , Yaqoub Roaya , Darwish Eman , Khawjah Afrah 
Published: January 2023

Introduction: Diabetes mellitus (DM) is a major chronic systemic health concern that could develop macro- and microvascular complications. One of the commonest microvascular complications is diabetic peripheral neuropathy (DPN) which is a type of nerve damage caused by uncontrolled hyperglycemia of diabetic patients. DPN is one of the most common causes of reduction in life quality and disability in DM patients, as well as; it overload the national health care system. Finding a cost-effective, easy prognostic marker to early detect DPN could be an important step in prevention DM complications. Our research aimed to assess the association between neutrophil to lymphocyte ratio and demographic and clinical data in diabetic neuropathy patients with average age of 60 years.
Methodology: A retrospective study was conducted on 133 patients by reviewing the data records over the period of 10 years from January 2012 to July 2022. The study was done at king Abdul-Aziz University Hospital, Jeddah, in the western region of KSA amongst diabetic peripheral neuropathy patients who are using either oral hypoglycemic agents or insulin with regular follow ups.
Results: The study included a total of 133 patients with most of them being male i.e., 81 (61%). The mean age of the patients was 60(SD13.5) years. Approximately two-third of the patients 86(64.7%) had diabetes for more than 10 years. There was no significant association identified for gender, age group, nationality, and medication (p >0.05) with HbA1c or NLR. Moreover, there was no significant association between NLR and HbA1c categories.
Conclusion: In conclusion our study showed non-significant relationship between NLR and DPN among elderly diabetic patient at King Abdu al-aziz university hospital (KAUH).
Characteristics Associated With Refractory Course, Blindness, and Treatment Strategy–Related Outcomes in Patients With Mucous Membrane Pemphigoid
Authors: Kridin Khalaf , van Beek Nina , Bühler Elena , Kochan Anne S. , Ranjbar Mahdy , Beissert Stefan , Zillikens Detlef , Günther Claudia , Schmidt Enno 
Published: January 2023

ImportanceMucous membrane pemphigoid (MMP) is a rare and heterogeneous subepithelial autoimmune bullous disease with predominant mucosal involvement. Characteristics associated with the disease course and complications are yet to be delineated.ObjectivesTo evaluate characteristics associated with refractory disease course and blindness among patients with MMP and to estimate the association of different treatment strategies with the prognostic outcome.Design, Setting, and ParticipantsA retrospective cohort study of consecutive patients diagnosed with MMP and followed up for more than 1 year from 2007 to 2020 in 2 tertiary referral centers. Data were analyzed from January 1, 2009, to June 30, 2020.Main Outcomes and MeasuresCharacteristics associated with refractory disease course and blindness were evaluated using multivariable logistic regression model.ResultsThe study encompassed 121 patients with MMP (mean [SD] age, 66.0 [14.0] years; 78 (64.5%) were women), of whom 56 (46.3%) followed a refractory course and 13 (10.7%) developed blindness. Anti–LAD-1 IgA (odds ratio [OR], 3.42; 95% CI, 1.11-10.52; P = .03) and anti–dermal-epidermal/epithelial junction (DEJ) IgG (by indirect immunofluorescence on human salt-split skin; OR, 2.92; 95% CI, 1.26-6.78; P = .01) were significantly associated with refractory course. Development of blindness was associated with older age (≥68 years; OR, 6.38; 95% CI, 1.35-30.16; P = .009), initial presentation with bilateral ocular involvement (OR, 7.92; 95% CI, 2.04-30.68; P = .001), and scarring ocular lesions (OR, 5.11; 95% CI, 1.47-17.79; P = .006). However, 4 (30.8%) and 2 (15.4%) of those experiencing blindness had no ocular scarring lesions and unilateral ocular involvement at the onset of their disease, respectively. Patients progressing to blindness were more likely to be treated by 3 or more immunosuppressive/immunomodulatory drugs (OR, 4.07; 95% CI, 1.17-14.14; P = .02) and by cyclophosphamide (OR, 7.64; 95% CI, 2.24-26.09; P &amp;lt; .001). Patients developing blindness and refractory course were more frequently managed by intravenous immunoglobulin (OR, 7.64; 95% CI, 2.24-26.09; P &amp;lt; .001 and OR, 3.47; 95% CI, 1.42-8.45; P = .005, respectively).Conclusions and RelevanceFindings of this cohort study support that patients with MMP with anti–LAD-1 IgA and anti-DEJ IgG reactivity should be carefully monitored. While initial bilateral ocular disease and scarring ocular lesions were associated with blindness, patients initially presenting with unilateral and nonscarring ocular disease may still develop severe vision impairment.
Hydrofluoric Acid‐Removable Additive Optimizing Electrode Electrolyte Interphases with Li+ Conductive Moieties for 4.5 V Lithium Metal Batteries
Authors: Jiang Gaoxue , Liu Jiandong , He Jian , Wang Huaping , Qi Shihan , Huang Junda , Wu Daxiong , Ma Jianmin 
Published: January 2023

AbstractHigh‐voltage lithium metal batteries (LMBs) are capable to achieve the increasing energy density. However, their cycling life is seriously affected by unstable electrolyte/electrode interfaces and capacity instability at high voltage. Herein, a hydrofluoric acid (HF)‐removable additive is proposed to optimize electrode electrolyte interphases for addressing the above issues. N, N‐dimethyl‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl) aniline (DMPATMB) is used as the electrolyte additive to induce PF6− decomposition to form a dense and robust LiF‐rich solid electrolyte interphase (SEI) for suppressing Li dendrite growth. Moreover, DMPATMB can help to form highly Li+ conductive Li3N and LiBO2, which can boost the Li+ transport across SEI and cathode electrolyte interphase (CEI). In addition, DMPATMB can scavenge traced HF in the electrolyte to protect both SEI and CEI from the corrosion. As expected, 4.5 V Li|| LiNi0.6Co0.2Mn0.2O2 batteries with such electrolyte deliver 145 mAh g−1 after 140 cycles at 200 mA g−1. This work provides a novel insight into high‐voltage electrolyte additives for LMBs.
Super‐Resolution Detection of DNA Nanostructures Using a Nanopore
Authors: Chen Kaikai , Choudhary Adnan , Sandler Sarah E. , Maffeo Christopher , Ducati Caterina , Aksimentiev Aleksei , Keyser Ulrich F. 
Published: January 2023

AbstractHigh‐resolution analysis of biomolecules has brought unprecedented insights into fundamental biological processes and dramatically advanced biosensing. Notwithstanding the ongoing resolution revolution in electron microscopy and optical imaging, only a few methods are presently available for high‐resolution analysis of unlabeled single molecules in their native states. Here, label‐free electrical sensing of structured single molecules with a spatial resolution down to single‐digit nanometers is demonstrated. Using a narrow solid‐state nanopore, the passage of a series of nanostructures attached to a freely translocating DNA molecule is detected, resolving individual nanostructures placed as close as 6 nm apart and with a surface‐to‐surface gap distance of only 2 nm. Such super‐resolution ability is attributed to the nanostructure‐induced enhancement of the electric field at the tip of the nanopore. This work demonstrates a general approach to improving the resolution of single‐molecule nanopore sensing and presents a critical advance towards label‐free, high‐resolution DNA sequence mapping, and digital information storage independent of molecular motors.
Coordinatively Stiffen and Toughen Hydrogels with Adaptable Crystal‐Domain Cross‐Linking
Authors: Xu Liju , Qiao Yan , Qiu Dong 
Published: January 2023

AbstractConventional hydrogels usually suffer from the inherent conflict between stiffness and toughness, severely hampering their applications as load‐bearing materials. Herein, an adaptable crystal‐domain cross‐linking design is reported to overcome this inherent trade‐off for hydrogels by taking full advantage of both deformation‐resisting and energy‐dissipating capacities of cross‐linking points. Through solvent exchange to homogenize the polymer network, followed by salting out to foster crystallization, a class of sal‐exogels with high number densities of uniform crystalline domains embedded in homogeneous networks is constructed. During the deformation, those adaptive crystalline domains initially survive to arrest deformation, while later gradually disentangle to efficiently dissipate energy, crucial to the realization of the desirable compatibility between stiffness and toughness. The resultant sal‐exogel achieves coordinatively enhanced stiffness (52.3 ± 2.7 MPa) and toughness (120.7 ± 11.7 kJ m−2), reconciling the challenging trade‐off between them. This finding provides a practical and universal route to design stiff and tough hydrogels and has a profound impact on many applications requiring hydrogels with such combined mechanical properties.
Nonanimal Euglena gracilis‐Derived Extracellular Vesicles Enhance Skin‐Regenerative Wound Healing
Authors: Ko Yuri , Baek Hwira , Hwang Jee‐Hyun , Kim Youngseok , Lim Kyung‐Min , Kim Junoh , Kim Jin Woong 
Published: January 2023

AbstractThis study proposes using microalgae‐containing carbohydrate bioactives, an Euglena gracilis‐derived extracellular microvesicle (EMVEG) system, for enhanced skin regeneration. The critical deformation ratio, 1.67, during cell extrusion enables the authors to tune the particle size of the EMVEG at ≈1 µm, thus satisfying the encapsulation yield of β‐1,3‐glucan and the cellular delivery performance. In vitro 5‐bromo‐2'‐deoxyuridine and cell scratch assays reveal that the EMVEG promotes the proliferation and migration of skin cells, thereby increasing both collagen synthesis and the expressions of proliferation‐associated proteins. An ex vivo wound‐healing test using both artificial and porcine skin reveals that similar to that seen using β‐1,3‐glucan, the EMVEG can substantially increase the cell population, expressing the proliferation‐related protein, termed proliferating cell nuclear antigen. These results demonstrate that the EMVEG system shows considerable potential in the field of skin regeneration. This technique is expected to design new types of extracellular vesicles that are applicable for skin regeneration in the pharmaceutical and cosmetic industries.
Bulk Incorporation with 4‐Methylphenethylammonium Chloride for Efficient and Stable Methylammonium‐Free Perovskite and Perovskite‐Silicon Tandem Solar Cells
Authors: Duong The , Nguyen Thuan , Huang Keqing , Pham Huyen , Adhikari Sunita Gautam , Khan Motiur Rahman , Duan Leiping , Liang Wensheng , Fong Kean Chern , Shen Heping , Bui Anh Dinh , Mayon Azul Osorio , Truong Thien , Tabi Grace , Ahmad Viqar , Surve Sachin , Tong Jingnan , Kho Teng , Tran‐Phu Thanh , Lu Teng , Zheng Jianghui , Paetzold Ulrich W. , Lemmer Uli , Baillie Anita Ho , Liu Yun , Andersson Gunther , White Thomas , Weber Klaus , Catchpole Kylie 
Published: January 2023

AbstractMethylammonium (MA)‐free perovskite solar cells have the potential for better thermal stability than their MA‐containing counterparts. However, the efficiency of MA‐free perovskite solar cells lags behind due to inferior bulk quality. In this work, 4‐methylphenethylammonium chloride (4M‐PEACl) is added into a MA‐free perovskite precursor, which results in greatly enhanced bulk quality. The perovskite crystal grains are significantly enlarged, and defects are suppressed by a factor of four upon the incorporation of an optimal concentration of 4M‐PEACl. Quasi‐2D perovskites are formed and passivate defects at the grain boundaries of the perovskite crystals. Furthermore, the perovskite surface chemistry is modified, resulting in surface energies more favorable for hole extraction. This facile approach leads to a steady state efficiency of 23.7% (24.2% in reverse scan, 23.0% in forward scan) for MA‐free perovskite solar cells. The devices also show excellent light stability, retaining more than 93% of the initial efficiency after 1000 h of constant illumination in a nitrogen environment. In addition, a four‐terminal mechanically stacked perovskite‐silicon tandem solar cell with champion efficiency of 30.3% is obtained using this MA‐free composition. The encapsulated tandem devices show excellent operational stability, retaining more than 98% of the initial performance after 42 day/night cycles in an ambient atmosphere.
Visible‐Light‐Promoted Electron Donor‐Acceptor Complex Enabled Decarboxylative Alkylation of Quinoxalin‐2(1H)‐ones and N‐Hydroxyphthalimide Esters with Na2S as a Catalytic Donor
Authors: Song Hai‐Yang , Zhang Zhuo‐Tao , Tan Hong‐Yu , Lu Yu‐Han , Yang Tian‐Bao , Chen Jin‐Yang , Ji Hong‐Tao , He Wei‐Min 
Published: January 2023

AbstractWe developed a novel and efficient method for the synthesis of various 3‐alkylated quinoxalin‐2(1H)‐ones (32 examples, 70%–96% yields) through electron donor‐acceptor complex enabled alkylation of quinoxalin‐2(1H)‐ones with N‐ hydroxyphthalimide esters as the alkyl source and Na2S as the catalytic electron donor under external photocatalyst‐, oxidant‐ and additive‐free conditions.