bluuebunny/crossref_metadata_2025_split huggingface dataset:
NIH HEAL Common Data Elements (CDE) implementation: NIH HEAL Initiative IDEA-CC
Authors: Adams Meredith C B , Hurley Robert W , Siddons Andrew , Topaloglu Umit , Wandner Laura D ,   ICDEWG, Adams Meredith C B , Arnsten Julia , Bao Yuhua , Barry Declan , Becker William C , Fiellin David , Fox Aaron , Ghiroli Megan , Hanmer Janel , Horn Brady , Hurlocker Margo , Jalal Hawre , Joseph Verlin , Merlin Jessica , Murray-Krezan Christina , Pearson Matthew , Rogal Shari , Starrels Joanna , Bachrach Rachel , Witkiewitz Katie , Vasquez Angel 
Published: February 2023

Abstract

Objective
The National Institutes of Health (NIH) HEAL Initiative is making data findable, accessible, interoperable, and reusable (FAIR) to maximize the value of the unprecedented federal investment in pain and opioid-use disorder research. This involves standardizing the use of common data elements (CDE) for clinical research.

Methods
This work describes the process of the selection, processing, harmonization, and design constraints of CDE across a pain and opioid use disorder clinical trials network.

Results
The network alignment allowed for incorporation of newer data standards across the clinical trials. Specific advances included geographic coding (RUCA), deidentified patient identifiers (GUID), shareable clinical survey libraries (REDCap), and concept mapping to standardized concepts (UMLS).

Conclusions
While complex, harmonization across a network of chronic pain and opioid use disorder clinical trials with separate interventions can be optimized through use of CDEs and data standardization processes. This standardization process will support the robust secondary data analyses. Scaling this process could standardize CDE results across interventions or disease state which could help inform insurance companies or government organizations about coverage determinations. The development of the HEAL CDE program supports connecting isolated studies and solutions to each other, but the practical aspects may be challenging for some studies to implement. Leveraging tools and technology to simplify process and create ready to use resources may support wider adoption of consistent data standards.
Cognitive-Motor Dual-Task Costs on Postural Sway During Sit-to-Stand Movement in Children With Cerebral Palsy
Authors: Lima Camila Resende Gâmbaro , Pavão Sílvia Leticia , da Silva Bruna Romão , de Campos Ana Carolina , Saavedra Sandra , Rocha Nelci Adriana Cicuto Ferreira 
Published: February 2023

Abstract

Objective
The purpose of this study was to investigate the cognitive-motor dual-task costs (DTCs) on postural sway of children with typical development (TD) and children with cerebral palsy (CP) during the sit-to-stand movement.

Methods
Twenty children with TD (mean age = 9.35 years) and 17 children with CP (mean age = 8.29 years) randomly performed 3 test conditions: simple motor task, low-complexity cognitive-motor dual-task, and high-complexity cognitive-motor dual-task. The sit-to-stand movement was divided into 3 phases for data analysis: preparation (P1), rising (P2), and stabilization (P3). For each of these phases, the DTCs were calculated by the percentage change in the center of pressure area of sway, velocity of sway, and duration variables between the simple and dual-task conditions. Analysis of variance was applied to test the group, task conditions, and interaction effects.

Results
Children with CP had lower DTC than children with TD in area of sway in P1 and P2 variables; anteroposterior velocity of sway in P1, P2, and P3; and duration in P3. Children with TD had higher DTC in the high-complexity cognitive-motor dual-task than in the low complexity one. Children with CP did not show adaptations between the dual-task conditions, showing no differences in DTCs.

Conclusion
The simultaneous performance of a motor task and a cognitive task seems to affect children with CP and children with TD differently, but the effects depend on the specific demands of each task. These results demonstrate the importance of rehabilitation actions to place demands involving a variety of postural sway strategies.

Impact
DTCs are different for children with TD and children with CP. Assessment and rehabilitation strategies must take into account the postural sway behavior of these children.
University–industry cooperation: a taxonomy of intermediaries
Authors: Santos Telmo N , Dias José G , Mendonça Sandro 
Published: February 2023

AbstractThe fragmentation of the literature on intermediaries between the university and industry has led to a disorganised and confused theoretical landscape. This research addresses this gap in the literature by proposing an analytical tool that can be used as guidance. For this purpose, this work provides a taxonomy of these intermediaries and classifies them into five different classes. To this end, we review 125 studies on university–industry cooperation (UIC) intermediaries. In addition to the general and innovation-related information, we extracted specific data related to the relevant UIC intermediaries from each article, i.e. the type(s) of intermediary addressed and its identified functions. This taxonomy is based on twenty-two functions identified in the UIC intermediary literature and thirteen UIC intermediary types. The five proposed classes of intermediaries are specialised in five different roles. This integrative background can be applied in future research and in the definition of policy-based guidelines.
European scholarly journals from small- and mid-size publishers: mapping journals and public funding mechanisms
Authors: Laakso Mikael , Multas Anna-Maija 
Published: February 2023

Abstract
This study investigates the relationship between scholarly journal publishing and public funding, specifically concerning the context of small- and mid-sized journal publishers in European countries. As part of the movement towards open science, an increasing number of journals globally are free to both read and publish in, which increases the need for journals to seek other resources instead of subscription income. The study includes two separate components, collecting data separately for each European country (including transcontinental states): (1) the volume and key bibliometric characteristics of small- and mid-sized journal publishers and (2) information about country-level public funding mechanisms for scholarly journals. The study found that there are 16,387 journals from small- and mid-sized publishers being published in European countries, of which 36 per cent are already publishing open access. There is a large diversity in how countries reserve and distribute funds to journals, ranging from continuous inclusive subsidies to competitive grant funding or nothing at all.
The dim light melatonin onset across ages, methodologies, and sex and its relationship with morningness/eveningness
Authors: Kennaway David J 
Published: February 2023

AbstractThe onset of melatonin secretion, the dim light melatonin onset (DLMO), is a tool for determining the phase of the circadian timing system. Although small studies have investigated the impacts of age and methods of calculating DLMO, there is no DLMO reference range. In the current study, the saliva DLMO from 3579 participants from 121 published studies and plasma DLMO from 818 healthy controls from 31 studies (aged 3–73 years) were analyzed. In a subset of 53 papers (1749 participants), individual saliva DLMO and Morningness Eveningness Questionaire (MEQ) scores were obtained from authors or mined from publications and a reference range was constructed. Saliva DLMO was earliest in children to 10 years of age and latest around 20 years of age and thereafter advanced with age by 30 min in the oldest participants. Melatonin assay methods and DLMO calculation methods had little effect on the determination of the DLMO. Saliva DLMO was correlated (p &lt; 0.001) with the MEQ score; lower MEQ scores were associated with later DLMO. MEQ scores increased with age, reflecting a tendency toward morningness. An evaluation of 14 saliva DLMO studies of clinically diagnosed patients living with delayed sleep–wake phase disorder (mean ages 20 to 31 years) revealed mean saliva DLMO within the reference range albeit at the late extreme. Peak plasma melatonin levels from 179 studies of healthy participants revealed a high degree of variability within studies and age groups, but only a small decline between the 20 and 50 years and lowest levels after 70 years.
Carcass and meat quality traits in Brangus steers
Authors: Rodriguez Eduardo E , Hamblen Heather , Flowers Sara , Leal Joel D , Carr Chad , Scheffler Tracy , Mateescu Raluca G 
Published: February 2023

Abstract
The quality grade system used in the United States to identify carcasses with superior eating satisfaction to consumers is based on the amount of marbling within the ribeye and the maturity of the carcass. However, the most important quality attribute for consumers is tenderness. The objective of this study was to investigate the phenotypic correlations between carcass and meat quality traits of strip loin steaks from Brangus steers, particularly the relation between the United States Department of Agriculture (USDA) quality grade and tenderness. Warner–Bratzler shear force (WBSF) values in this study averaged 5.10 ± 0.96 kg, slightly higher than the national average of 4.55 ± 1.14 kg. Average WBSF across all quality grades ranged from 4.90 to 5.27 kg with standard deviations ranging from 0.78 to 1.40 kg. In the present Brangus steer population, there was a weak negative (−0.13) but favorable correlation (P &lt; 0.05) between marbling score and tenderness measured through WBSF. The USDA quality grade had a significant (P = 0.02) effect on WBSF. The WBSF least square means were significantly higher in the Select compared with the Choice¯, and Choiceº quality grades. The Choice⁺ and Prime quality grades were not significantly different from any quality grades regarding the WBSF. The standard quality grade did not have significantly different WBSF least square means from any other quality grade. The range of WBSF values was large, especially in the lower quality grade categories, indicating that there is considerable variation in tenderness, even within quality grade. The high level of variation in tenderness within USDA quality grades highlights the limitation of the USDA grading system to predict eating quality or tenderness.
The Howard Street Method: A Community Pharmacy-led Low Dose Overlap Buprenorphine Initiation Protocol for Individuals Using Fentanyl
Authors: Noel Marnie , Abbs Elizabeth , Suen Leslie , Samuel Lysa , Dobbins Sarah , Geier Michelle , Soran Christine S. 
Published: February 2023

Objectives
Buprenorphine treatment significantly reduces morbidity and mortality for people with opioid use disorder. Fear of precipitated withdrawal remains a barrier to starting buprenorphine for patients who use synthetic opioids, particularly fentanyl. We aim to evaluate the development and implementation of a buprenorphine low dose overlap initiation (LDOI) protocol in an urban public health community pharmacy.

Methods
We performed a retrospective chart review of patients with nonprescribed fentanyl use (N = 27) to examine clinical outcomes of a buprenorphine LDOI schedule, named the Howard Street Method, dispensed from a community pharmacy in San Francisco from January to December 2020.

Results
Twenty-seven patients were prescribed the Howard Street Method. Twenty-six patients picked up the prescription and 14 completed the protocol. Of those who completed the protocol, 11 (79%) reported no symptoms of withdrawal and 3 (21%) reported mild symptoms. Four patients (29%) reported cessation of full opioid agonist use and 10 (71%) reported reduction in their use by the end of the protocol. At 30 days, 12 patients (86%) were retained in care and 10 (71%) continued buprenorphine. At 180 days, 6 patients (43%) were retained in care and 2 (14%) were still receiving buprenorphine treatment.

Conclusions
We found that a LDOI blister-pack protocol based at a community pharmacy was a viable intervention for starting buprenorphine treatment and a promising alternative method for buprenorphine initiation in an underresourced, safety-net population of people using fentanyl.
Military Soft Skills Applicable to the ICU
Authors: Chalela Julio A. , Britell Patrick 
Published: February 2023

OBJECTIVES:
To describe how soft skills acquired during military service can be applied to the practice of critical care medicine.

DATA SOURCES:
A systematic search was performed in PubMed.

STUDY SELECTION:
We selected all studies that addressed soft skills in medicine.

DATA EXTRACTION:
Information present in published articles was analyzed by the authors and incorporated in the article if relevant to the practice of critical care medicine.

DATA SYNTHESIS:
Integrative review of 15 articles combined with the authors' clinical experience practicing military medicine in country and overseas while also practicing academic intensive care medicine.

CONCLUSIONS:
Soft skills used in the military have potential applications to modern intensive care medicine. Teaching soft skills in parallel with the technical aspects of intensive care medicine should be an integral part of critical care fellowships.
Comparison of Doses from Disposals of Technologically Enhanced Naturally Occurring Radioactive Materials in Kentucky and Oregon
Authors: Caffrey Emily A. , Rood Arthur S. , Grogan Helen A. , Mangini Colby , Till John E. 
Published: February 2023

Abstract
Oil and natural gas fracking waste contains technologically enhanced naturally occurring radioactive material (TENORM) and has increasingly been disposed of in unpermitted landfills, causing concern among regulators and the public about potential exposures. There are numerous issues with TENORM waste, including the lack of Federal regulations on its disposal and the lack of permitted landfills capable of accepting these waste streams. This paper examines two situations in which TENORM was placed in unpermitted landfills, one in Kentucky and one in Oregon. The same modeling and dose calculation methods were used in both cases, allowing for a comparison between the two sites. Site-specific differences, source terms, and doses from the disposals and potential remediation options are discussed and compared. Predicted groundwater concentrations are shown and compared against the relevant regulations for each site. Despite the differences in site and TENORM waste characteristics, it was more protective of the community and the environment to leave the waste in place at both sites. Radiation doses to landfill workers on site and to members of the public were low, both during the original disposal and for the remediation alternatives evaluated. Removal of the TENORM material in either case presents significant non-radiological risks that outweigh any benefit from the long-term dose reduction.
Escherichia coli-related disseminated intravascular coagulation: Case report and literature review
Authors: Wu Junjun , Li Huaming , Wang Yufang , Xu Rong 
Published: February 2023

Background:

Escherichia coli can cause severe infections. The latter can lead to disseminated intravascular coagulation (DIC). The importance of an early diagnosis of DIC is illustrated through this case report.

Aim:
Review the utility and shortcomings of representative clinical indicators of E coli infection and DIC.

Case report:
A 48-year-old man presented with diarrhea, nausea, and vomiting with fever of 2-day duration, during which consciousness was lost for 12 hour. Hematology was undertaken. The coagulation profile, liver function, and kidney function were determined, and blood cultures undertaken. The final diagnosis was acute gastroenteritis complicated by DIC. Meropenem (1.0 g, q8h, i.v.) was started, along with active replacement of fluids. Anticoagulant therapy (low-molecular-weight heparin 0.4 mL, q.d.s.) was given. Plasma supplementation of coagulation factors and albumin was applied. On day-5 of therapy, hematology showed the platelet count, D-dimer level, and prothrombin time to be improved significantly. Low-molecular-weight heparin treatment was stopped and antibiotic treatment was continued for 1 week. The patient made a full recovery.

Conclusions:
In severe infection, timely assessment of the platelet count, procalcitonin level, coagulation function, as well as rational use of antibiotics, can improve the prognosis of patients.
Effectiveness and safety of electroacupuncture combined with conventional drugs in the treatment of stable angina pectoris in coronary artery disease: A systematic evaluation and meta-analysis
Authors: Pang Shuwen , Lv Yajuan , Zhong Wenfang , Qian Jing , Zhao Yueli , Zhong Jiahui , Huang Weiyi 
Published: February 2023

Background:
The objective of this study is to systematically evaluate the clinical effectiveness and safety of electroacupuncture combined with conventional drugs in the treatment of stable angina pectoris.

Methods:
Computer searches of 3 Chinese literature databases (CNKI, VIP, WangFang) and 4 English literature databases (PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science), all searched from the time of database construction to October 2022. Two researchers were selected to independently perform literature screening, data extraction, and risk of bias evaluation, and meta-analysis of the included studies was performed using RevMan 5.3 software.

Results:
A total of 7 publications with a total of 1042 patients were included, and electroacupuncture combined with conventional drug therapy compared with drug therapy alone was effective in improving clinical symptoms of angina pectoris (relative risk [RR] = 1.19, 95% CI = [1.09, 1.31], P = .0002), clinical treatment efficiency of electrocardiography (RR = 1.34, 95% CI = [1.19, 1.50], P = .00001), visual analog score (VAS) (mean deviation = 0.07, 95% CI = [−0.11, 0.25], P = .44), and Seattle Angina Scale (mean deviation = 4.91, 95% CI = [2.91, 6.91], P < .00001) were better than conventional drug therapy, while the number of adverse events in the intervention group was lower than that in the control group. One of the outcome indicators with greater heterogeneity was tested by sensitivity analysis, and each outcome indicator was found to be more robust. The risk of bias evaluation of each outcome indicator using funnel plots suggested the possibility of publication bias.

Conclusion:
The current study results found that electroacupuncture combined with conventional drugs can significantly improve the clinical symptoms of patients with stable angina pectoris compared with conventional drug therapy, with a low incidence of adverse reactions, but the number of high-quality literature with rigorous study design protocols is currently low, which may cause bias in the results of this study, so the above conclusions need to be further verified through clinical trials.
The Role of Anxiety Sensitivity in the Association Between Childhood Maltreatment and Sleep Disturbance Among Adults in Psychiatric Inpatient Treatment
Authors: Amarneh Dania , Lebeaut Antoine , Viana Andres G. , Alfano Candice A. , Vujanovic Anka A. 
Published: February 2023

Abstract
The present investigation examined associations of childhood maltreatment, anxiety sensitivity (AS), and sleep disturbance among a diverse sample of adults in psychiatric inpatient treatment. We hypothesized that childhood maltreatment would be indirectly associated with greater sleep disturbance through elevated AS. Exploratory analyses examined the indirect effect models with three AS subscales (i.e., physical, cognitive, and social concerns) as parallel mediators. A sample of adults in acute-care psychiatric inpatient treatment (N = 88; 62.5% male; M
age = 33.32 years, SD = 11.07; 45.5% White) completed a series of self-report measures. After accounting for theoretically relevant covariates, childhood maltreatment was indirectly associated with sleep disturbance through AS. Parallel mediation analyses revealed that no individual subscale of AS significantly accounted for this association. These findings suggest that heightened levels of AS may explain the association between childhood maltreatment and sleep disturbance among adults in psychiatric inpatient treatment. Interventions targeting AS can be brief and efficacious and have the potential to improve clinical outcomes among psychiatric populations.
Multimorbidity and Correlates of Comorbid Depression and Generalized Anxiety Disorder in a Nationally Representative US Sample
Authors: Jegede Oluwole , Stefanovics Elina A. , Rhee Taeho Greg , Rosenheck Robert A. 
Published: February 2023

Abstract
Generalized anxiety disorder (GAD) and major depressive disorder (MDD) frequently occur together, but sociodemographic, behavioral, and diagnostic correlates of this comorbidity have not been comprehensively studied. Data from the nationally representative US sample surveyed in the National Epidemiologic Survey on Alcohol and Related Conditions–III (N = 36,309) were used to define three groups, individuals with a) both past-year GAD and MDD (n = 909, 16.9%), b) GAD only (n = 999, 18.6%), and c) MDD only (n = 3471, 64.5%). The comorbid group was compared with each single-diagnosis group on sociodemographic, behavioral, and diagnostic characteristics based on effect sizes (risk ratios and Cohen's d) rather than p values because of the large sample sizes. Multivariable-adjusted logistic regression analyses were used to identify factors independently associated with the comorbid group. Bivariate analysis showed that the comorbid group had more parental and childhood adversities, additional psychiatric disorders, and poorer mental health quality of life than both single-disorder groups. Multivariable-adjusted logistic regression of the comorbid group showed that on two of five factors, additional psychiatric diagnoses were significantly more frequent than in the GAD-only group, and that on three of six factors, additional psychiatric diagnoses were significantly more frequent than in the MDD-only group. There is a significantly higher burden of social adjustment problems, comorbid psychiatric disorders, and poorer mental health–related quality of life among individuals with comorbid GAD-MDD than those with single disorders. The adversities associated with this non-SUD psychiatric comorbidity are comparable to those associated with the more extensively studied comorbidity of psychiatric and substance use disorders and deserve further research and treatment.
Clinical Nurse Specialist and Clinical Nurse Leader Collaboration During the COVID-19 Pandemic
Authors: Cosper Pamela , Bossie Julia , Bond Cynthia L. , Hunter Donna 
Published: February 2023

Purpose
The aim of this study was to describe an innovative strategy to maintain healthcare worker safety and optimal patient outcomes that was implemented by a healthcare system in the Southeastern United States during the COVID-19 pandemic.

Program Description
During the surges of the COVID-19 pandemic, healthcare systems have struggled with healthcare worker burnout, high staff turnover rates, and redeployment of staff to unfamiliar areas and the uncertainty regarding COVID-19 personal protection and patient care. Clinical nurse specialist/clinical nurse leader teams were created to help ensure healthcare worker safety and optimize patient care outcomes.

Outcome
Healthcare worker safety and desired patient outcomes were maintained. Throughput was expedited for emergency department patients, and there was timely implementation of therapeutic modalities for critically ill patients.

Conclusion
Clinical nurse specialist/clinical nurse leader team collaboratively cross-trained staff to ensure their safety and delivery of quality patient care. The team was pivotal in helping safeguard staff from harm while optimizing patient outcomes. Lessons learned will help us in future disasters as well as our daily operations.