bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Ford Female Achievement Model for Excellence (F2AME): Empowering Black Females for Success
Authors: Middleton Tanya , Ford Donna 
Published: June 2023

The educational realities for Black female students attending predominantly White institutions (PWIs) are experiences too often omitted or sub-grouped with Black male student experiences. The academic resiliency of this dual minority group who continue to outpace their racial counterparts in postsecondary degree completion has received increased attention. Black females are double ‘minorities’ who contend with racism and sexism by virtue of being Black and female. Therefore, the psychological and emotional costs of navigating through such unfavorable environments warrant a deeper conversation. This article reviews the academic climate, and socioemotional and psychological factors faced by Black females enrolled in two PWI contexts – gifted and talented education (GATE) and in higher education – with strategies for support and success framed in Ford’s Female Achievement Model for Excellence (F2AME).
Synthesis, characterization, and performance of chitosan/nylon 6/polyurethane blend for the removal of chromium (VI) and lead (II) ions from aqueous solutions for enhanced kinetic adsorption studies
Authors: Jayakumar S. , Sudarsan S. , Sridhar B. , Parthiban E. , Prabu A. V. , Jha Sudan 
Published: June 2023

Abstract

Adsorption is vital for the elimination of Cr6+ and Pb2+ ions in the contaminated solution medium. A ternary blend made up of chitosan, nylon 6 and polyurethane foam (CS/Ny 6/PUF) blend in the ratio of 2:1:1 has been investigated. These blends are used as an adsorbent due to the insoluble nature in acidic and basic medium. The adsorption efficacy was analyzed by modifying pH, contact time, and adsorbent dosage. The maximum uptake of metal ions has been exhibited in the pH range 5. An equilibrium adsorption statistic indicated that adsorption isotherm follows the Freundlich model. The adsorption kinetic parameters specified that the adsorption of chromium has shown pseudo-second-order and lead pseudo-first-order reaction.
A Novel Hypoxia-related lncRNA Risk Score Model for Prognosis Evaluation
of Clear Cell Renal Cell Carcinoma
Authors: Liu Fu , Li Xinyuan , Zhou Xiang , Tong Hang , Hu Zili , Bai Xuesong , Gou Xin 
Published: June 2023

Background:
Renal cell carcinoma is the most common aggressive tumor of the genitourinary system. The main pathological subtype is clear cell renal cell carcinoma (ccRCC), and its treatment options are very limited. Therefore, identifying specific biomarkers of ccRCC is of great significance for diagnosis and prognosis.

Methods:
First, we obtained transcriptome data and clinical data of 611 patients with renal clear cell carcinoma to analyze the relationship between hypoxia-related lncRNAs and overall survival (OS). We screened hypoxia-related lncRNAs through Pearson correlation and Cox regression analysis. Univariate and multivariate regression analysis were applied to assess survival-related risk factors. According to the median risk score, patients were divided into two groups. Next, a nomogram map was built, and GSEA was used for gene function annotation. RT-qPCR, Western Blot, and Flow Cytometry were used to determine the role of SNHG19 in RCC cells.

Results:
By analyzing the co-expression of hypoxia genes and lncRNAs, 310 hypoxia-related genes were obtained. Four sHRlncRs (AC011445.2, PTOV1-AS2, AP004609.3, and SNHG19) with the highest prognostic values were included in the group to construct the HRRS model. The high-risk group had a shorter OS than the low-risk group. HRRS was considered to be an independent prognostic factor and associated with OS. The two groups showed different pathways in GSEA. Experiments showed that SNHG19 plays essential roles in the autophagy and apoptosis of RCC cells.

Conclusion:
We constructed and validated a hypoxia-related lncRNA model for ccRCC patients. This study also provides new biomarkers for the poor prognosis of ccRCC patients.
Gelatin-based Targeted Delivery Systems for Tissue Engineering
Authors: Zhai Xinyue , Wu Yuqian , Tan Huaping 
Published: June 2023

Abstract:Gelatin is an attractive material for drug delivery and tissue engineering applications due to its excellent biocompatibility and biodegradability, which has been utilized as cell, drug, and gene carriers. Gelatin is less immunogenic compared to collagen and its precursor and retains informational signals, such as RGD (Arg-Gly-Asp) sequence, thus promoting cell adhesion and proliferation. To tune the mechanical strength and bioactivity, gelatin can be easily modified via chemical reactions and physical methods to obtain various derivatives. Furthermore, gelatin-based biomaterials can be achieved through chemical immobilization of specific molecules and physical combination with other biopolymers. This review focuses on the recent advances of gelatin and its derivatives as biomaterials in the field of drug delivery, including cell scaffolds for tissue engineering applications.
Maternal High Fat Diet and its Expressions in the Heart and Liver in
the Mice Embryogenesis
Authors: Nirala Sanjeev , Tan Xue-Rui , Shafiq Muhammad , Basnet Rajesh , Singh Apekshya 
Published: June 2023

Background:
The developmental biology for the nonalcoholic fatty liver
disease and coronary heart disease are known but elaborative ideas of triglycerides
phenomenon in the embryo-genesis of the liver and the heart are still not clear.

Objective:
The aim of the study was to relate different triglycerides like LXRα, LPL, LDL
R, PPARG-, SREBP-1C expression in the high fat fed mice with the normal fed diet
mice in the process of developmental and embryo-genesis biology.

Methods:
Tissue preparation was done by ripalysis. Different protein content was
obtained via western blot for the 6 samples namely a-17.5 days mice embryo heart; b-
0th day or the birthday mice infant heart; c-1 week mice infant heart; d-2 weeks mice
infant heart; e-3 weeks mice infant heart; f-Adult mice heart. Protein lysates from the
heart tissues of the mice was obtained via homegenization and centrifugation.
Hematoxylin and Eosin (H and E) was done to see the fat droplets in the liver tissues at
the different developmental stages.

Result:
LXRα,SREBP-1C expression in 17.5 days mice embryo heart and 0th day or
the birthday mice infant heart is highly expressed in the high fat diet. LDL-R in the high
fat diet mice is increased in 2 weeks mice infant heart but in17.5 days mice embryo
heart and in 0th day or the birthday mice infant heart it is low expression but from 1week
mice infant heart to the adult mice heart the expression is in decreasing trend. Similarly
LPL is highly expressed in17.5 days mice embryo heart and 1 week mice infant heart
and thus low expression in decreasing order until adult mice heart.Thus, these results
collectively shows that maternal HF diet increases expression of proteins such as LPL,
LDLr in the embryo phase and thus getting normal expressions in the adult phase that
facilitate Triglycerides (TAG) hydrolysis across the liver and the heart. Also,maternal
high fat diet increases the SREBP1c expression, leading to stimulation of LPL
Expression.

Conclusion:
In summary, using a pregnant mice model, we found that maternal high fat
diet increases the fetal fat accumulation. Elevated placental LPL activity and expression
of genes that facilitate placental lipid transport suggest that enhanced placental lipid
transport may play a key role in maternal nutrition and obesity-induced fetal fat
accumulation.
Analysis of Harmonic Compensation for Grid-side Current of Series
Sixfold-circuit “Phase-hopping” AC-AC Frequency Converter
Authors: Yang Jixin , Xu Zhengwang , Zhu Jin , Zhang Jiarui , Shen Shikang 
Published: June 2023

Background:
A series sixfold-circuit “phase-hopping” AC-AC frequency converter
(SSCPH-AAFC) is an extension of traditional AC-AC frequency converters. Compared to traditional
frequency converters, it has the advantages of energy-saving, low cost, and simple control.
Additionally, it can increase the upper limit of the frequency conversion to the power frequency.
Through multiplexing processing, it reduces the harmonic content of the output waveform,
making it suitable for applications, such as large-capacity fan or pump speed control.

Objective:
Although SSCPH-AAFC reduces harmonic content, the harmonic content of the single-
phase and three-phase grid-side currents still reach 14.65% and 10.20%, respectively. To
meet national standards for practical application, a compensation circuit needs to be designed to
further reduce grid-side current harmonics.

Methods:
To address harmonic problems, a targeted single-phase current open-loop compensation
method was designed based on the analysis of the current waveform defect. The method
compensated for harmonics by selecting appropriate trigger angles and reducing the harmonic
distortion rate of the power grid to meet the necessary application standards.

Results:
The method was simulated and analyzed using MATLAB, and the results showed that
after single-phase open-loop compensation, the total harmonic distortion (THD) of the grid-side
current for a single-phase SSCPH-AAFC was 2.64%, and for a three-phase SSCPH-AAFC, it
was 1.80%.

Conclusion:
This method has a good effect and can meet the standard requirements.
Green Capping Agents and Digestive Ripening for Size Control of
Magnetite for Magnetic Fluid Hyperthermia
Authors: Kahil Heba , Ali Ismail Abd El-Rahim , Ebraheem Hadir 
Published: June 2023

Background:
Magnetite is the most recognized iron oxide candidate used for various biological
applications.

Objective:
This work is a complete study that addresses the synthesis of magnetic nanoparticles and
investigates the feasibility of using green tea and ascorbic acid as capping agents.

Methods:
Synthesis of magnetite by two wet chemical methods namely: coprecipitation and solvothermal
methods. The samples were characterized using X-ray diffraction (XRD), transmission
electron microscope (TEM), and vibrating sample magnetometer (VSM).

Results:
The results reveal the impact of coating on the size and morphology of the particles. The
study also proves that autoclaving the samples prepared by coprecipitation results in smaller particle
size and narrower size distribution due to digestive ripening. In addition, a novel and facile methodology
for coating magnetite with polyethylene glycol is presented. The potential of the particles to be
used for magnetic fluid hyperthermia is assessed by measuring the specific absorption rate (SAR) of
the samples.

Conclusión:
The results show that all the prepared magnetite samples showed a promising capacity to
be used as magnetic fluid hyperthermia agents.
Timing of Kidney Replacement Therapy among Children and Young Adults
Authors: Larkins Nicholas G. , Lim Wai , Goh Carrie , Francis Anna , McCarthy Hugh , Kim Siah , Wong Germaine , Craig Jonathan C. 
Published: June 2023

Background
No randomized trials exist to guide the timing of the initiation of KRT in children. We sought to define trends and predictors of the eGFR at initiation of KRT, center-related clinical practice variation, and any association with patient survival.

Methods
Children and young adults (1–25 years) commencing KRT (dialysis or kidney transplantation) between 1995 and 2018 were included using data from the Australia and New Zealand Dialysis and Transplant Registry. The associations between eGFR on commencing KRT and covariates were estimated using quantile regression. Cox regression was used to estimate the association between eGFR and patient survival. Logistic regression, categorizing eGFR about a value of 10 ml/min per 1.73 m2, was used in conjunction with a random effect by center to quantify clinical practice variation.

Results
Overall, 2274 participants were included. The median eGFR at KRT initiation increased from 7 to 9 ml/min per 1.73 m2 over the study period and the 90th centile from 11 to 17 ml/min per 1.73 m2. The effect of era on median eGFR was modified by modality, with a greater increase among those receiving a preemptive kidney transplant (1.0 ml/min per 1.73 m2 per 5 years; 95% confidence interval [CI], 0.6 to 1.5) or peritoneal dialysis (0.7 ml/min per 1.73 m2 per 5 years; 95% CI, 0.4 to 0.9) compared with hemodialysis (0.1 ml/min per 1.73 m2 per 5 years; 95% CI, −0.1 to 0.3). There were 252 deaths (median follow-up 8.5 years, interquartile range 3.7–14.2) and no association between eGFR and survival (hazard ratio, 1.01 per ml/min per 1.73 m2; 95% CI, 0.98 to 1.04). Center variation explained 6% of the total variance in the odds of initiating KRT earlier. This rose to over 10% when comparing pediatric centers alone.

Conclusions
Children and young adults progressively commenced KRT earlier. This change was more pronounced for children starting peritoneal dialysis or receiving a preemptive kidney transplant. Earlier initiation of KRT was not associated with any difference in patient survival. A substantial proportion of clinical practice variation was due to center variation alone.

Podcast
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Development of an Approach to Assess the Consequences of Fuel-Air Mixtures Explosions Taking into Account the Development Features
Authors: Тyurin A. P. , Yannikov I. M. 
Published: June 2023

Introduction. In the study of the problem of the impact of negative factors from explosions at gas stations on people and the infrastructure of settlements, a probabilistic approach is often used. The limitation of this approach is that when it is implemented, the concept of clutter of the surrounding space does not reflect the relationship between the area occupied by buildings and the total area affected by the shock wave. Therefore, this article is devoted to the development and justification of an approach to assessing the consequences of explosions of fuel-air mixtures (FA), taking into account the peculiarities of the development of settlements. The work objective is to develop an approach for assessing the consequences of explosions of fuel-air mixtures, taking into account the development features. The solution to this problem will facilitate decision-making for the development of effective protective measures for surrounding objects.Materials and Methods. The authors have conducted an analytical review of the research results in the field of study and the existing approaches to assessing the consequences of explosions at filling stations (FS) and gas stations (GS), based on the specific conditions of their location on the territory of settlements.Results. An approach has been developed to assess the consequences of explosions of fuel-air mixtures, taking into account the development features. The main causes, types of accidents with an explosion at a gas station and the scale of their consequences have been identified. Along with the theoretical justification of the issue under consideration, the authors provide a detailed description of the applied research methodology, as well as the characteristics of the objects of research, taking into account their location. When calculating the consequences of explosions of fuel-air mixtures, it was proposed for the first time to use a development density factor equal to the ratio of the area of the existing facilities to the total area of the territory affected by the shock wave. This approach justifies the need to apply additional protective measures in the areas where gas stations are located. The methods of analysis used are described in detail with justification of the reliability of the measurement results.Discussion and Conclusion. The application of the approach proposed in the article for calculating the consequences of an explosion of fuel-air mixtures, taking into account the development density, makes it possible to control the location and the level of risk from possible explosions at gas stations in a real situation. The proposed approach for calculating the consequences allows you to quickly assess possible risks in real time and plan specific measures to minimize them in accordance with the existing situation in the area of the gas station.
Production Facilities Safety Assessment According to the Maximum Values of Machines Reliability
Authors: Deryushev V. V. , Teplyakova S. V. , Zaitseva M. M. 
Published: June 2023

Introduction. At the stage of designing technical devices and performing appropriate strength calculations of metal structures, sufficiently large reserves of strength are taken, which, theoretically, exclude any failures of parts. In fact, the machines work with frequent failures. Of interest are undiagnosed failures that lead to a critical decrease in safety, especially at hazardous production facilities. It is assumed that the previously applied approaches of selective determination of the maximum (minimum) reliability value, based on point estimates of the distribution parameters of the two-parameter Weibull law, lead to an overestimation of the calculated indicators of the probability of failure-free operation, i.e. underestimation of risk. Therefore, the work objective is to consider an approach to assessing the risk of operating production facilities in a situation of accidental occurrence of dangerous and undiagnosed failures in systems.Materials and Methods. Methods for technical devices safety assessment based on probability theory were used in the work, and the probability of machine failure was determined based on the well-known method of reliability theory. This method consists in calculating and constructing distribution functions of random variables (load-bearing capacity and loading) that influence the occurrence of failure. The level of increase in the reliability index was determined, leading to frequent unpredictable failures of technical devices (machines) and a decrease in the safety of their operation.Results. The signs of inconsistency of strength calculations based on overestimated safety margins, which in theory exclude failures of parts and machines in general, are identified and substantiated. A new approach to risk assessment of operating production facilities in a situation of accidental occurrence of dangerous and undiagnosed failures by safety systems has been developed and implemented. An algorithm for determining the three parameters of Weibull's law for a population based on sample data has been developed. The resource distribution densities of the boom of the single-bucket excavator EK-14 are constructed. The recommendations are given to increase the probability of failure-free operation to 0.9989.Discussion and Conclusion. The results of the conducted research allow us to substantiate a new approach to risk assessment of operating production facilities in the event of dangerous and undiagnosed failures of basic parts by safety systems, leading to negative consequences.
Hubungan Imunisasi Anak Dengan Persepsi Minum Susu Pasca Covid 19 Di Masyarakat Desa Nagrog Kecamatan Cicalengka Kabupaten Bandung
Authors: Christi Raden Febrianto , Suharwanto Dwi , Salman Lia Budimulyati Salman Budimulyati , Gharizah Alhuur Ken Ratu 
Published: June 2023

Imunisasi adalah kegiatan rutin bulanan yang umumnya dilakukan oleh petugas posyandu untuk memberikan vaksin kepada bayi dan balita. Tujuan kegiatan ini adalah meningkatkan pengetahuan dan pelaksanaan program imunisasi pasca covid 19 dengan persepsi minum susu. Pengabdian Kepada Masyarakat melalui program Kuliah Kerja Nyata (KKN) dengan telah dilaksanakan pada bulan Juli-Agustus 2022 di Desa Nagrog Kecamatan Cicalengka Kabupaten Bandung. Sasaran adalah orang tua yang telah memiliki balita dan anak kurang dari 10 tahun. Kegiatan diikuti 50 peserta tanpa dikelompokan secara umur dan jumlah anak. Metode dalam pelaksanaan kegiatan ini adalah menyiapkan (pre test) secara tulisan kemudian menyebarkanya kepada peserta dan melakukan pengumpulan jawaban dilanjutkan dengan ceramah atau pemberian materi imunisasi, diskusi dan tanya jawab antara narasumber dengan peserta. Hasil menunjukkan pre test bahwa peserta mengetahui dan memahami imunisasi serta hubunganya dengan persepsi minum susu pasca covid 19 sebesar 60%, sedangkan 40% belum mengetahui. Sedangkan post test meningkat menjadi 100% artinya terdapat peningkatan pengetahuan dan pemahaman terhadap imunisasi anak dengan persepsi minum susu. Kesimpulan penyuluhan kegiatan imunisasi anak pasca pandemi covid 19 pada masyarakat Desa Nagrog Kecamatan Cicalengka Kabupaten Bandung dapat meningkatkan pemahaman, keaktifan serta antusias dalam usaha kegiatan program imunisasi dengan persepsi minum susu.
Cryoballoon ablation for atrial fibrillation in octogenarians: a propensity score-based analysis with a younger cohort
Authors: Cecchini Federico , Mugnai Giacomo , Kazawa Shuichiro , Bolzan Bruna , Iacopino Saverio , Maj Riccardo , Placentino Filippo , Ribichini Flavio , Sieira Juan , Sofianos Dimitrios , Sorgente Antonio , Tomasi Luca , de Asmundis Carlo , Chierchia Gian-Battista 
Published: June 2023

Background
In terms of safety and efficacy, cryoballoon ablation (CB-A) has become a valid option for achieving pulmonary vein isolation (PVI) in patients affected by symptomatic atrial fibrillation. However, CB-A data in octogenarians are still scarce and limited to single-centre experiences. The present multicentre study aimed to compare the outcomes and complications of index CB-A in patients older than 80 years with a cohort of younger patients.

Methods and results
We retrospectively enrolled 97 consecutive patients aged ≥80 years who underwent PVI using the second-generation CB-A. This group was compared with a younger cohort of patients using a 1:1 propensity score matching. After the matching, 70 patients from the elderly group were analysed and compared with 70 younger patients (control group). The mean age was 81.4 ± 1.9 years among octogenarians and 65.2 ± 10.2 years in the younger cohort. The global success rate after a median follow-up of 23 [18–32.5] months was 60.0% in the elderly group and 71.4% in the control group (P = 0.17). Phrenic nerve palsy was the most common complication occurring in a total of 11 patients (7.9%): in 6 (8.6%) patients in the elderly group and in 5 patients (7.1%) in the younger group (P = 0.51). Only two (1.4%) major complications occurred: one (1.4%) femoral artery pseudoaneurysm in the control group, which resolved with a tight groin bandage, and one (1.4%) case of urosepsis in the elderly group. Arrhythmia recurrence during the blanking period and the need for electrical cardioversion to restore sinus rhythm after PVI were found to be the only independent predictors of late arrhythmia relapses.

Conclusions
The present study showed that CB-A PVI is as feasible, safe and effective among appropriately selected octogenarians as it is in younger patients.