bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of steel beams with external pretension, considering the environmental and financial impact
Authors: Fiorotti Kamila Madeira , Silva Gabrieli Fontes , Calenzani Adenilcia Fernanda Grobério , Alves Élcio Cassimiro 
Published: March 2023

Abstract
With the advancement technology for reinforced concrete structures, it becomes increasingly feasible to use this technology for steel structures. The objective of this work is to present the formulation of the optimization problem of steel beams with external pretension with straight or polygonal tracing cables, considering the environmental and economic impacts. For the objective function formulation, the minimization of CO2 emission and cost in the design of the structure was considered. As constraints were established the states limits imposed by ABNT NBR 8800:2008. The program was developed within the MATLAB Platform (2016) and the optimization problem solution was obtained through the native Genetic Algorithms method. Routine validation was performed using examples found in the literature and an analysis of the predominant collapse modes was performed. The results indicate that monosymmetric profiles have gains when it comes to reducing CO2 emissions and cost when compared to doubly symmetrical profiles, in addition it was observed that straight cables generate better values of CO2 emission and cost when compared to polygonal cables.
Melatonin alleviates pyroptosis by regulating SIRT3/FOXO3α/ROS axis and interacting with apoptosis
Authors: Cong Lin , Liu Xiankun , Bai Yiming , Qin Qin , Zhao Lili , Shi Ying , Bai Yunpeng , Guo Zhigang 
Published: March 2023

Abstract
Atherosclerosis (AS), a significant contributor to cardiovascular disease (CVD), is steadily rising with the aging of the global population. Pyroptosis and apoptosis, both caspase-mediated cell death mechanisms, play an essential role in the occurrence and progression of AS. The human pineal gland is the primary producer of melatonin (MT), an indoleamine hormone with powerful anti-oxidative, anti-pyroptosis, and anti-apoptotic properties. This study examined MT's antioxidative stress and anti-pyroptotic effects on human THP-1 macrophages treated with nicotine. Our research found that MT downregulated NOD-like receptor family protein 3 (NLRP3) inflammasome, ASC, and caspase-1 expressions and abrogated the release of Interleukin-1β (IL1β) and Interleukin-18 (IL-18), indicating effective pyroptosis inhibition. These changes were paralleled by a reduction in reactive oxygen species (ROS) production, reversal of sirtuin3 (SIRT3), and Forkhead box O3 (FOXO3α) upregulation. The findings suggest that MT is a viable strategy for counteracting pyroptosis and apoptosis in AS patients by up-regulating SIRT3, promoting FOXO3α, and suppressing ROS production. In inhibiting pyroptosis, MT also inhibits apoptosis, mainly caused by the interaction of caspase-1 and caspase-3 proteins. In vivo studies using ApoE-/- mice confirmed that nicotine could accelerate plaque formation caused by high-fat diets. Moreover, mice treated with MT showed a significant reduction in AS lesion area and increased in cellulose level. Importantly, our understanding of the inhibitory pathways for macrophage pyroptosis will allow us to identify other novel therapeutic targets that will help treat, prevent, and reduce AS-associated mortality.
Mental health treatment programs for children and young people in secure settings: A systematic review
Authors: Schutte Valerie , Danseco Evangeline , Lucente Gabrielle , Sundar Purnima 
Published: March 2023

Abstract

Background:While there are mental health treatment programs for children and young people in secure settings (i.e., secure treatment programs) in many countries, there is a lack of transparency and consistency across these that causes confusion for stakeholders and challenges for the design and delivery of high-quality, evidence-based programs. This systematic review addresses two questions: What do mental health treatment programs for children and young people in secure community settings look like across jurisdictions? What is the evidence underlying the various components of these programs?Methods:Twelve databases were searched in November 2021: CINAHL, EMBASE, MEDLINE, PsycINFO, PubMed, Scopus, Science Direct, Academic Search Complete, Psychology and Behavioral Sciences collection, Google Scholar, OpenDOAR, and GreyLit.org. To be included, publications had to be empirical literature or a report on mental health treatment within a secure setting for people under the age of 25; contain pre-identified keywords; be based on a research or evaluation study conducted since 2000; and be assessed as low risk of bias using an adaptation of the Critical Appraisal Skills Programme qualitative research checklist. The systematic review included 63 publications. Data were collected and analyzed in NVivo qualitative software using a coding framework.Results:There are secure treatment programs in Australia, Belgium, Canada, New Zealand, the Netherlands, England and Wales, Scotland, and the United States of America. Although there are inconsistencies across programs in terms of the systems in which they are embedded, client profiles, treatments provided, and lengths of stays, most share commonalities in their governance, definitions, designs, and intended outcomesConclusions:The commonalities across secure treatment programs appear to stem from them being designed around a need for treatment that includes a mental disorder, symptom severity and salience involving significant risk of harm to self and/or others, and a proportionality of the risks and benefits of treatment. Most share a common logic; however, the evidence shows that this logic tends not to lead to sustained outcomes. Policymakers, service providers, and researchers could use the offered recommendations to ensure the provision of high-quality secure treatment programming to children and young people with serious and complex mental health needs.
NL-1 restores oxidative stress and apoptosis via mitoNEET induced mitophagy after subarachnoid hemorrhage in rats
Authors: Zhang Tongyu , Zhang Minghai 
Published: March 2023

Abstract

Background:NL-1, a ligand of mitoNEET with antileukemic effect. Recent study proved that it binds to mitoNEET resulting in neuroprotective effects of ischemic stroke model. However, its underlying process in subarachnoid hemorrhage (SAH) is still unclear. Thus, we aimed to investigate the possible mechanism of NL-1 after SAH in rats.Methods:112 male adult Sprague-Dawley rats were used for experiments. SAH model was performed with endovascular perforation. Rats were given intraperitoneally (i.p.) with NL-1 (3 mg/kg, 10 mg/kg, 30mg/kg) or a vehicle (10% DMSO aqueous solution) at 1h after SAH. A novel mitophagy inhibitor liensinine (60 mg/kg) was injected i.p. 24 hours before SAH. SAH grades, short-term and long-term neurological scores were measured for neurobehavior. TdTmediated dUTP nick end labeling (TUNEL) staining, dihydroethidium (DHE) staining and western blot measurements were used to detect the outcomes and mechanisms of NL-1 administration.Results:NL-1 treatment significantly improved short-term neurological behavior in Modified Garcia and beam balance sores in comparison with SAH + vehicle group. NL-1 administration also increased mitoNEET which induced phosphatase and tensin-induced kinase 1 (PINK1), Parkin and LC3II related mitophagy compared with SAH + vehicle group. In addition, the expressions of apoptotic protein Cleaved Caspase-3 and oxidative stress related protein Romo1 in NL-1 treatment group were reversed from SAH + vehicle group. Meanwhile, NL-1 treatment notably reduced TUNEL-positive cells, DHE-positive cells compared with SAH + vehicle group. NL-1 treatment notably improved long-term neurological behavior in rotarod and water maze tests compared to SAH + vehicle group. However, liensinine could abolish the treatment effects of NL-1 on neurobehavior and pathway related proteins’ expression.Conclusions:NL-1 induced PINK1/PARKIN related mitophagy via mitoNEET, which reduced oxidative stress and apoptosis in early brain injury after SAH in rats. NL-1 may serve as a prospective drug for the treatment of SAH.
How can local government contribute to the development of social capital? A novel strategy for local and integrated sustainability
Authors: Shafieisabet Naser , Khaksar Sogand 
Published: March 2023

Abstract
One of the most critical elements of local and integrated sustainability is raising the social capital of the villagers, even though the effectiveness of the local administration influences this. Enhancing the many facets of villagers' social capital is challenging and sometimes needs to be within reach in underdeveloped nations. Only a few studies have looked at the variables that might prevent or promote the development of villagers' social capital related to their involvement in integrated, sustainable local development projects. This article investigates the figure of social capital in sustainable, locally based rural development in Tehran Province, Iran, to fill this knowledge gap. The results show the intrinsic barriers to improving social capital dimensions because of exogenous factors affecting local government. They use empirical data, such as legal and regulatory factors, government policy-making, and local government dependence on the national government, especially in top-down management like Iran, the framework of social organizations related to formal institutions. Findings also show that if the local government's exogenous factors and the villagers' power are improved, their social capital will increase, and the local government and villagers can use it. Such knowledge can transform the villagers' experiences to enhance their social capital by focusing on a pattern between themselves and their settlement. The villagers' social capital can significantly enable them to achieve what they aspire to in local and integrated sustainability rural development and make actual change. This article concludes with this analysis's implications for improving villagers' social capital in local and integrated sustainability.
Some Double Series for Π and Their q-analogues
Authors: Gu Guoping , Wang Xiaoxia 
Published: March 2023

Abstract
In this paper, by applying the partial derivative operator on summation formulas of hypergeometric series and basic hypergeometric series, we establish several double series for π and their q-analogues.
2010 Mathematics Subject Classification. Primary 33C20; Secondary 05A10, 33D15.
Double-Pulley, V-Shaped Fixation Technique for Arthroscopic Repair of Ideberg Type IA Glenoid Fracture
Authors: Li Baichuan , Sun Jianchao , Rong Ke , Deng Haiquan , Tang Zhongfei , Tang Jian 
Published: March 2023

Abstract

Background: Different techniques have been described for glenoid fractures, there is still a need for safe and effective agents to promote outcomes. To evaluate the clinical effect of the Double-pulley, V-shaped fixation technique under arthroscopy in the treatment of Ideberg Type IA glenoid fractures.
Methods: From January 2016 to April 2021, the clinical data of 17 patients with pulley type IA fractures treated by the V-shaped fixation technique under shoulder arthroscopy were retrospectively analyzed. Preoperative X-ray, CT, and MRI examinations were completed, and the average defect area of glenoid fracture was 25%. The functional score of the shoulder joint, such as the visual analog scale (VAS), Constant score, and Modified Rowe score, was used to evaluate the preoperative and final follow-up clinical outcomes. The active shoulder range of motion (ROM) was also collected preoperatively and at the final postoperative follow-up (forward flexion and abduction). Accordingly, intraoperative and postoperative complications were also observed.
Results: The mean follow-up was 49.52 months (16-79 months). The patients’ follow-up exams showed that shoulder joint flexion, abduction, external rotation, internal rotation, and pain were not significantly different from those of the contralateral side (p > 0.05). The mean Constant score was 83.52 (58-98), and the average Modified Rowe score was 94.29 (70-100). X-ray and CT films of all cases showed good healing without articular depression or steps. Three patients had traumatic arthritis, with VAS<3 pain. No postoperative complications, such as infections, nerve or vessel damage, or suture anchor problems occurred during the follow-up period.
Conclusions:Using the Double-pull, V-shaped fixation technique can stabilize the reduction of glenoid fractures while reducing the possibility of bone destruction. It is a good solution and provides an opportunity to treat rotator cuff tears associated with the procedure. However, there is an extended learning curve for shoulder arthroscopy.
Using LAP PROTECTOR™ to prevent subcutaneous emphysema after robotic gastrectomy
Authors: Hayashi Kengo , Inaki Noriyuki , Sakimura Yusuke , Yamaguchi Takahisa , Obatake Yoshinao , Terai Shiro , Kitamura Hirotaka , Kadoya Shinichi , Bando Hiroyuki 
Published: March 2023

Abstract
Subcutaneous emphysema (SE), a complication of robotic gastrectomy (RG), occurs when the gas used to establish pneumoperitoneum escapes and enters the soft tissue. SE typically does not result in major clinical problems, but massive SE can have life-threatening consequences. Hence, developing adequate preventive methods against postoperative SE is essential. We aimed to determine whether an existing protective device, the LAP PROTECTOR™ (LP), can be used to reduce the incidence of SE after RG. We analyzed the data of 194 patients who underwent RG at our hospital between August 2016 and December 2022. Since September 2021 (the 102nd patient), we have used the LP (FF0504; Hakko Medical, Hongo, Tokyo, Japan) at the trocar site, as this was expected to reduce the incidence of SE. The primary endpoint of this study was the efficacy of the LP in reducing the incidence of clinically relevant SE (defined as SE extending into the cervical area) a day after RG. Univariate analysis revealed that sex, body mass index (BMI), and LP usage differed significantly between patients with and without postoperative SE. Logistic regression analysis revealed that male sex (odds ratio [OR]: 0.22, 95% confidence interval [CI]: 0.15–0.72, P < 0.001), high BMI (OR: 0.13, 95% CI: 1.23–4.45, P = 0.009), and LP usage (OR: 0.11, 95% CI: 0.04–0.3, P < 0.001) were preventive factors independently associated with a lower incidence of clinically relevant SE. Placing an LP at the trocar site may be a safe and effective method of preventing SE after RG.
Simplified deep-learning approach for estimating the ultimate axial load of circular composite columns
Authors: Veerapandian Varunkumar , Pandulu Gajalakshmi , Jayaseelan Revathy , Y Mohammed Asif M 
Published: March 2023

Abstract
Composite columns were preferred over Reinforced Concrete columns in modern-day construction techniques due to their confinement effect. Different materials were utilized as the outer confining tube and are mainly characterized by their mechanical properties. The main objective of this research is to develop a novel simplified Artificial Neural Network model for the determination of the ultimate axial load of the circular composite columns irrespective of the type of confining tube. A database had been created with the existing experimental results of the composite columns and is employed for training, testing, and validation of the model. A set of composite columns were selected from the real-time experimental study and the ultimate axial load of the columns was determined and validated against the developed model. A user-friendly graphical user interface is created from the proposed model which can help the researchers for anticipating the ultimate axial load of the circular composite columns easily and efficiently.
Effectiveness of conjunctival-limbal autograft with marginal Tenon’s layer excision in pterygium treatment: non-randomized comparative study
Authors: Çiftçi Süleyman 
Published: March 2023

Abstract
Purpose: To unveil the success rate of conjunctival-limbal autograft with marginal Tenon’s layer excision (CLAG-MTE) on pterygium recurrence rate.
Materials and Methods: This study is an interventional non-randomized, non-equivalent control group design. Data of 40 patients in CLAG group and 38 patients in CLAG-MTE group retrospectively reviewed. Patients of the both series were selected from whose surgeries were performed from February 2008 to January 2015. The recurrence rate of conjunctival-limbal autograft (CLAG) and CLAG-MTE was compared. And also, the limbal-conjunctival series of some studies which reported a high success rate on recurrence rate and Hirst's preliminary series were included in this comparison.
Results: The recurrence rate was 5.1% (4 eyes) in the CLAG group and 0% in the CLAG-MTE group. The mean follow-up period was 21.1±5.6 months in the CLAG group and 22.6±6.8 in the CLAG-MTE group. In Fisher's Exact Test, the difference in recurrence rate between the CLAG and the CLAG-MTE groups was not statistically significant.
When all the series were compared by One-way ANOVA in respect to recurrence rate, significant differences were found between a number of them. CLAG series, still, were found successful like CLAG-MTE series. However, when they were compared with Hirst’s and Al Fayez’s series, CLAG-MTE series were found to be more successful than CLAG series. Also, in the means of plot analysis, the CLAG-MTE series were showing the lowest plot while the CLAG and Güler’s series were showing the highest plot. The other series -especially the Hirst’s- ranked in between.
Conclusions: CLAG-MTE is the most effective in preventing recurrence among the techniques which were compared in this study. Moreover, it is relatively easy and less invasive in comparison to Hirst's technique.

Synopsis
The CLAG-MTE is a successful technique. Besides, Tenon’s capsule pulleys are not touched and it is done far from semilunar fold. So, the surgery involves only the ocular surface.
Awake craniotomy for high-grade gliomas – a prospective cohort study in a UK tertiary- centre
Authors: Ramakrishnan Piravin Kumar , Saeed Fozia , Thomson Simon , Corns Robert , Mathew Ryan K. , Sivakumar Gnanamurthy 
Published: March 2023

Abstract
Background:
Awake craniotomy (AC) is preferred for maximising extent of resection (EOR) in high-grade glioma (HGG) in eloquent regions without worsening neurological function. Studies from the UK reporting on AC include a heterogenous group of patients which limit the evaluation of the true impact of AC in HGG patients. This study aims to report solely the experience and outcomes of AC for HGG surgery from our centre.
Methods:
A prospective review of all patients who underwent AC for HGG from 2013–2019 were performed. Data on patient characteristics including but not limited to demographics, pre- and post-operative Karnofsky performance status (KPS), tumour location and volume, type of surgery, EOR, tumour histopathology, intra- and post-operative complications, morbidity, mortality, disease recurrence, progression-free survival (PFS) and overall survival (OS) from the time of surgery were collected.
Results:
Fifteen patients (6 males;9 females;17 surgeries) underwent AC for HGG (median age:55; range:26–73 years). Two patients underwent repeat surgeries due to disease recurrence. Median pre- and post-operative KPS score was 90 (range:80–100) and 90 (range:60–100), respectively. The EOR ranges from 60–100% with a minimum of 80% achieved in 81.3% cases. There were 15 cases of glioblastoma IDH-wildtype, CNS WHO Grade 4, 1 case of oligodendroglioma IDH-mutant 1p/19-codeleted, CNS WHO grade 3, and 1 case of Astrocytoma IDH-mutant, CNS WHO grade 3. Post-operative complications include focal seizures (17.6%), transient aphasia/dysphasia (17.6%), permanent motor deficit (11.8%), transient motor deficit (5.9%) and transient sensory disturbance(5.9%). There were no surgery-related mortality or post-operative infection. The median PFS and OS were 13 (95%CI 5–78) and 30 (95%CI 21–78) months, respectively.
Conclusion:
This is the first study in the UK to solely report outcomes of AC for HGG surgery. Our data demonstrates that AC for HGG in eloquent region is safe and feasible and provides comparable outcomes to those reported in the literature.
Assessment of Arsenic (As)-Induced Hepato-Nephro alterations, enzymatic inhibition and Neurobehavioral instability in Charles foster rats
Authors: Shankar Prabhat , Singh Rana Vikram , Srivast Abhinav , Kumar Arun 
Published: March 2023

Abstract
The extremely hazardous trace metal arsenic is ubiquitous in the Earth’s crust contaminating groundwater globally. The present study was conducted to evaluate the arsenic-induced hepato-nephro alterations, enzymatic inhibition and neurobehavioral instability and in Charles foster rats. Rats were divided into four groups (n = 6; each) weighing with 160 ± 20 g. The group I (control) received arsenic free distilled water and remaining three treatment group (group II − 5 mg kg− 1 body weight, group III; 8mg kg− 1 body weight and group IV; 12mg kg− 1 body weight) were treated with Sodium arsenite (NaAsO2) in combination with distilled water for 90 days. This experimental exposure reveals severe haematological, biochemical and histopathological changes along with neuro-behavioural disorders. The presence of arsenic in blood were analysed through Graphite Furnace Atomic Absorption Spectrophotometer (GF-AAS). Compare to control group the analysed level of arsenic is too high in blood. The saviour significantly (P < 0.0001) changes were observed in haematological and hepato-nephro biochemical parameters. In observational view the behavioural infirmities, weight loss, hair loss, keratosis and the limb paralysis seen. The study concludes that regular exposure of arsenic significantly alters the levels of antioxidants (ROS) and leads to severe cellular alteration in hepato-nephro region compare to control group.