bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional and seasonal variability in human thermal stress in Poland
Authors: Tomczyk Arkadiusz M. , Bednorz Ewa 
Published: March 2023

AbstractThe study objective was to determine the spatial and temporal variability of Poland’s bioclimatic conditions and to designate heat-stress regions with the Universal Thermal Climate Index (UTCI) application. The study was based on daily data from the multiannual period 1966–2021 obtained for 37 stations in Poland, provided from the resources of the Institute of Meteorology and Water Management–National Research Institute (IMGW-PIB). The aforementioned data provided the basis for the calculation of the Universal Thermal Climate Index (UTCI). The study revealed high variability of bioclimatic conditions in Poland, both in temporal and spatial terms. Bioclimatic regions characterised by the different occurrence of heat stress were distinguished and characterised. Regions in the south-west and west of Poland proved the most favourable in bioclimatic terms, with the highest number of days with no thermal stress. In these regions, the highest UTCI values were observed, while the lowest were recorded in the northeast of Poland and at the east coast of the Baltic Sea. Among unfavourable biometeorological conditions, the ones causing hypothermia have so far occurred more frequently than the ones causing overheating of the human organism. However, UTCI has increased during the study period; therefore, under proceeding global warming, an increase in the frequency of occurrence of heat stress can be expected. So far, the most intensive increase in UTCI values in Poland was recorded in spring and the weakest in winter.
Time-Averaged Analysis and Numerical Modelling of the Behavior of the Multiphase Flow and Liquid Lamella Thickness Inside an Internal-Mixing ACLR Nozzle
Authors: Ballesteros Martínez Miguel Ángel , Gaukel Volker 
Published: March 2023

AbstractThe Air-Core-Liquid-Ring (ACLR) atomizer is an innovative internal-mixing pneumatic atomization technique, suitable for energy-efficient spray drying of highly viscous liquid feeds, with high solid contents. However, pneumatic atomizers such as the ACLR can suffer from unstable internal flow conditions, which may lead to a wide variation in the droplet diameter obtained. Therefore, the internal flow conditions of an ACLR-atomizer needs to be properly studied and comprehended. With that in mind, a computational fluid dynamic (CFD) model was implemented and tested with experimental data collected for different air pressures and liquid feed viscosities. The model used can predict average lamella thickness with a relative error of less than 10%, when compared to experimental results, although some degree of artificial dampening of the flow instabilities occurs at high viscosities and low pressures. These instabilities have to be investigated in more detail from both the numerical side, by further refining the CFD model to capture the moment-to-moment behavior of the flow, as well as on the experimental side, by studying the instability development at higher recording speeds.
Evaluation of combination treatment with DS-1205c, an AXL kinase inhibitor, and osimertinib in metastatic or unresectable EGFR-mutant non-small cell lung cancer: results from a multicenter, open-label phase 1 study
Authors: Yang James Chih-Hsin , Su Wu-Chou , Chiu Chao-Hua , Shiah Her-Shyong , Lee Kang-Yun , Hsia Te-Chun , Uno Makiko , Crawford Nigel , Terakawa Hiroshi , Chen Wen-Chi , Takayama Gensuke , Hsu Ching , Hong Ying , Saintilien Carline , McGill Joseph , Chang Gee-Chen 
Published: March 2023

SummaryThe objective of this study was to evaluate the safety and tolerability of DS-1205c, an oral AXL-receptor inhibitor, in combination with osimertinib in metastatic or unresectable EFGR-mutant non-small cell lung cancer (NSCLC) patients who developed disease progression during EGFR tyrosine kinase inhibitor (TKI) treatment. An open-label, non-randomized phase 1 study was conducted in Taiwan, in which 13 patients received DS-1205c monotherapy at a dosage of 200, 400, 800, or 1200 mg twice daily for 7 days, followed by combination treatment with DS-1205c (same doses) plus osimertinib 80 mg once daily in 21-day cycles. Treatment continued until disease progression or other discontinuation criteria were met. At least one treatment-emergent adverse event (TEAE) was reported in all 13 patients treated with DS-1205c plus osimertinib; with ≥ 1 grade 3 TEAE in 6 patients (one of whom also had a grade 4 increased lipase level), and 6 patients having ≥ 1 serious TEAE. Eight patients experienced ≥ 1 treatment-related AE (TRAE). The most common (2 cases each) were anemia, diarrhea, fatigue, increased AST, increased ALT, increased blood creatinine phosphokinase, and increased lipase. All TRAEs were non-serious, with the exception of an overdose of osimertinib in 1 patient. No deaths were reported. Two-thirds of patients achieved stable disease (one-third for > 100 days), but none achieved a complete or partial response. No association between AXL positivity in tumor tissue and clinical efficacy was observed. DS-1205c was well-tolerated with no new safety signals in patients with advanced EGFR-mutant NSCLC when administered in combination with the EFGR TKI osimertinib. ClinicalTrials.gov; NCT03255083.
Efficiency of large-scale aided phytostabilization in a mining pond
Authors: Shahrokh Vajihe , Martínez-Martínez Silvia , Faz Ángel , Zornoza Raúl , Acosta Jose A. 
Published: March 2023

AbstractMining activities accumulate large quantities of waste in tailing ponds, which results in several environmental impacts. In Cartagena–La Unión mining district (SE Spain), a field experiment was carried out in a tailing pond to evaluate the effect of aided phytostabilization on reducing the bioavailability of zinc (Zn), lead (Pb), copper (Cu) and cadmium (Cd) and enhancing soil quality. Nine native plant species were planted, and pig manure and slurry along with marble waste were used as amendments. After 3 years, the vegetation developed heterogeneously on the pond surface. In order to evaluate the factors affecting this inequality, four areas with different VC and an area without treatment (control area) were sampled. Soil physicochemical properties, total, bioavailable and soluble metals, and metal sequential extraction were determined. Results revealed that pH, organic carbon, calcium carbonate equivalent and total nitrogen increased after the aided phytostabilization, while electrical conductivity, total sulfur and bioavailable metals significantly decreased. In addition, results indicated that differences in VC among sampled areas were mainly owing to differences in pH, EC and concentration of soluble metals, which in turn were modified by the effect of non-restored areas on close restored areas after heavy rains due to a lower elevation of the restored areas compared to the unrestored ones. Therefore, to achieve the most favorable and sustainable long-term results of aided phytostabilization, along with plant species and amendments, micro-topography should be also taken into consideration, which causes different soil characteristics and thus different plant growth and survival.
Climate Change and Anti-Meaning
Authors: Di Paola Marcello , Nyholm Sven 
Published: March 2023

AbstractIn this paper, we propose meaningfulness as one important evaluative criterion in individual climate ethics and suggest that most of our greenhouse gas emitting actions, behaviours, and lives are the opposite of meaningful: anti-meaningful. We explain why such actions etc. score negatively on three important dimensions of the meaningfulness scale, which we call the agential, narrative, and generative dimensions. We suggest that thinking about individual climate ethics also in terms of (anti-) meaningfulness illuminates important aspects of our troubled ethical involvement with CC and can make a fresh and fruitful contribution to existing discussions, which tend to focus on moral responsibility and obligations.
Ownership, governance, and internationalization in family firms: a replication and extension
Authors: Debellis Francesco , Pinelli Michele , Hülsbeck Marcel , Heider Anne 
Published: March 2023

AbstractIn one of the most influential studies on family firm internationalization, Sciascia et al. (2012) advance a curvilinear relationship between family ownership and firm internationalization. We replicate their study adopting a three-step approach. First, we use the same measures on a different sample to test the generalizability of their findings. Second, we change the independent variable and hypothesize a negative relationship between family involvement in the board of directors and firm internationalization. Third, we introduce and measure the moderating role of firm age and firm size in this relationship. Our study advances the family firm internationalization literature both theoretically and methodologically. Theoretically, we show that it is not so much family ownership per se, but the influence the family obtains through board directorship that affects the family firm internationalization strategy. In addition, we show that this effect is moderated by firm age and size. Methodologically, our study is an important step forward toward increasingly transparent and replicable family business research.
Design optimization of multi-functional multi-lobe cryogenic fuel tank structures for hypersonic vehicles
Authors: Rodríguez-Segade Miguel , Steelant Johan , Hernáández Santiago , Díaz Jacobo 
Published: March 2023

AbstractHypersonic hydrogen-powered cruise vehicles offer promise for economical and reliable high-speed atmospheric transport. In recent years, several vehicle concepts have been developed in which the integration of fuel tanks is a major challenge, as they feature complex aerodynamic designs. In this work, we explore the viability of multi-lobe hydrogen tanks as a solution to obtain lightweight and volume-efficient structures. To do so, a parametric finite-element model was developed to fit multi-lobe geometries inside hypersonic vehicles. The parametric model was then incorporated into an optimization that minimizes the mass and maximizes the fuel capacity of the tank. The methodology is organized in two steps: the global search is driven by a two-level optimization consisting of a genetic algorithm with a nested gradient-based method; and a local search where each design is further improved to obtain a Pareto front. As presented in the results, this is a promising approach for designing multi-lobe tanks for complex geometries.
Determining the effect of mineral scaling formation under different injection water sources on the performance of Mishrif carbonate reservoir in Halfaya oilfield, Southern Iraq
Authors: Ghalib Hussein B. , Al-Hawash Adnan B. , Muttashar Wisam R. , Bozdag Ayla , Al-Saady Asaad A. 
Published: March 2023

AbstractThe chief source of the oilfield scale is the mixing of incompatible waters. This study demonstrated that mixing the reservoir of Mishrif formation (Halfaya oilfield) with six types of injection water sources, including Tigris River water, producing water formation, Gulf seawater, Marshes water, Middle Kirkuk formation water, and Main Outfall Drain water (AL-Masab AL-Aam Channel), leads to the formation of salt crusts that cause the reduction of reservoir rock permeability. According to the Piper diagram, the Mishrif formation water of all extant water samples was of the sodium chloride type (NaCl), except for HF-81, which was between (NaCl) and mix (CaMgCl) type. A geochemical simulation model of water alignment (PHREEQC) was used to simulate this problem, and it revealed the mineral scaling from mixing processes. These minerals precipitate in rock pores and clog them, which then cause damage to the petrophysical properties of the reservoir and prevent the passage of liquids. Results showed that the best water types used for injection are Middle Kirkuk formation water, followed by the general downstream, then Gulf seawater, but treatment before injection is needed. The study of geochemical modeling method can help to better understand scaling issues by efficiently identifying the best injection water from various selected types with the lowest possible cost, which in turn improves oil production.
System integration based on packing, piping and harness routing automation using graph-based design languages
Authors: Dinkelacker J. , Kaiser D. , Panzeri M. , Parmentier P. , Neumaier M. , Tonhäuser C. , Rudolph S. 
Published: March 2023

AbstractThe implementation of a fully instrumented, automated and simulation-enabled engineering software platform capable of automating the currently still manual model-based systems engineering (MBSE) design process for physical systems architecture generation and optimization in an aircraft wing is presented. The software platform uses graph-based design languages to integrate and entirely automate the mainly manual packing, piping and harness routing design. This design automation and optimization is achieved by a novel software stack of an optimization software coupled with a design compiler. It is shown that through rule-based model generation by a design compiler in the form of a design graph as a central data model, a cross-domain data consistency is achieved. This allows for automated execution and coupling of engineering tasks over several different domains such as packing, piping and routing design to converge to an optimized wing physical architecture design variant in agreement with given predetermined design constraints.
Foliar Spray of Stigmasterol Regulates Physiological Processes and Antioxidant Mechanisms to Improve Yield and Quality of Sunflower Under Drought Stress
Authors: Hanafy Rania Samy , Sadak Mervat Shamoon 
Published: March 2023

AbstractDrought stress is an unavoidable challenge limiting plant production and quality. Stigmasterol is a potential compound for plant protection and improvement productivity under drought. Thus, the effects of using stigmasterol as exogenous treatment on improving growth and productivity of sunflower grown under drought were studied. A pot experiment was carried out at two summer seasons, using foliar treatment of stigmasterol 0, 100, 200, and 300 mg L−1 on sunflower plants under different irrigation levels 80% and 50% water irrigation requirement (WIR). Drought stress (50% WIR) provoked significant reductions in growth and yield components; the percentages of decrease in head diameter reached 26.55%, head circumference 26.05%, seed weight per plant 36.26%, and 100 seed weight 29.61%, via decreasing photosynthetic pigments and indole acetic acid while elevating hydrogen peroxide (H2O2), lipid peroxidation (MDA), membrane leakage, lipoxygenase activity, some antioxidant compounds, enzymes, and osmolytes. Stigmasterol has a promotive effect on growth and productivity of sunflower through improving photosynthetic pigments, indole acetic acid, non-enzymatic, enzymatic antioxidant, and osmolytes, while it decreased membrane leakage, H2O2, and MDA, thus, improving yield quality. Moreover, stigmasterol improves the economic importance of sunflower seed oil. About 200 mg L−1 of stigmasterol was the most effective concentration in improving yield parameters, as it causes 19.84% and 25.29% in seed weight per plant and 26.72% and 33.95% of 100 seed weight under 80% and 50% WIR, respectively. Stigmasterol improved growth and productivity of sunflower under normal water conditions and could overcome the reduced impact of drought by improving growth and development and different physiological attributes.
Variability in Newborn Screening Across Canada: Spinal Muscular Atrophy and Beyond
Authors: Groulx-Boivin Emilie , Osman Homira , Chakraborty Pranesh , Lintern Stacey , Oskoui Maryam , Selby Kathryn , Van Caeseele Paul , Wyatt Alexandra , McMillan Hugh J. 
Published: March 2023

ABSTRACT:Background:Newborn screening (NBS) identifies infants with severe, early-onset diseases, enabling early diagnosis and treatment. In Canada, decisions regarding disease inclusion in NBS programs occur at the provincial level, which leads to variability in patient care. We aimed to determine whether important differences exist in NBS programs across provinces and territories. Given that spinal muscular atrophy (SMA) is the most recent disease added to NBS programs, we hypothesized that its inclusion would show interprovincial variability and be more likely in provinces already screening for a greater number of diseases.Methods:We conducted a cross-sectional survey of all NBS labs in Canada to understand: 1) what conditions were included in their program; 2) what genetic-based testing was performed and; 3) if SMA was included.Results:All NBS programs (N = 8) responded to this survey by June 2022. There was a 2.5-fold difference in the number of conditions screened (N = 14 vs N = 36) and a 9-fold difference in the number of conditions screened by gene-based testing. Only nine conditions were common to all provincial NBS programs. NBS for SMA was performed in four provinces at the time of our survey, with BC recently becoming the fifth province to add SMA to their NBS on October 1, 2022. Currently, 72% of Canadian newborns are screened for SMA at birth.Conclusion:Although healthcare in Canada is universal, its decentralization gives rise to regional differences in NBS programs which creates inequity in the treatment, care, and potential outcomes of affected children across provincial jurisdictions.
Adopting a Global AMR Target within the Pandemic Instrument Will Act as a Catalyst for Action
Authors: Van Katwyk Susan Rogers , Wilson Lindsay , Weldon Isaac , Hoffman Steven J. , Poirier Mathieu J.P. 
Published: March 2023

AbstractEnsuring that life-saving antimicrobials remain available as effective treatment options in the face of rapidly rising levels of antimicrobial resistance will require a massive and coordinated global effort. Setting a collective direction for progress is the first step towards aligning global efforts on AMR. This process would be greatly accelerated by adopting a unifying global target — a well-defined global target that unites all countries and sectors. The proposed pandemic instrument — with its focus on prevention, preparedness and response — represents an ideal opportunity to develop and adopt a unifying global target that catalyzes global action on AMR. We propose three key characteristics of a unifying global target for AMR that — if embedded within the pandemic preparedness instrument — could rally public support, funding, and political commitment commensurate with the scale of the AMR challenge.
Equitable Access to Antibiotics: A Core Element and Shared Global Responsibility for Pandemic Preparedness and Response
Authors: Ren Mengying , So Anthony D. , Chandy Sujith J. , Mpundu Mirfin , Peralta Arturo Quizhpe , Åkerfeldt Kerstin , Sjöblom Anna Karin , Cars Otto 
Published: March 2023

AbstractSecuring equitable antibiotic access as an essential component for health system resilience and pandemic preparedness requires a systems perspective. This article discusses key components that need to be coordinated and paired with adequate financing and resources to ensure antibiotic effectiveness as a global public good, which should be central while discussing a new global agreement.
An Awkward Fit: Antimicrobial Resistance and the Evolution of International Health Politics (1945-2022)
Authors: Kirchhelle Claas , Podolsky Scott H. 
Published: March 2023

AbstractDespite being acknowledged as a major global health challenge, growing levels of antimicrobial resistance (AMR) in pathogenic and commensal organisms have proven an awkward fit for international health frameworks. This article surveys the history of attempts to coordinate international responses to AMR alongside the origins and evolution of the current international health regulations (IHR). It argues that AMR, which encompasses a vast range of microbial properties and ecological reservoirs, is an awkward fit for the ‘organismal’ philosophies that centre on the rapid control of individual pathogens that have characterised international policy-making since the 19th century.
Using the International Pandemic Instrument to Revitalize the Innovation Ecosystem for Antimicrobial R&D
Authors: Caceres Andrea Morales , Singh Kshitij Kumar , Minssen Timo , Van Katwyk Susan Rogers , Hoffman Steven J. 
Published: March 2023

AbstractThe inclusion of antimicrobial resistance (AMR) and increased research and development (R&D) capabilities in the most recent outline of the World Health Organization’s (WHO’s) international pandemic instrument signals an opportunity to reshape pharmaceutical R&D system in favour of antimicrobial product development. This article explains why the current innovation ecosystem has disadvantaged the creation of antimicrobial products for human use. It also highlights how the COVID-19 pandemic experience can inform and stimulate international cooperation to implement innovative R&D incentives to bring new, life-saving antimicrobial products to the market.
Embed Multisectoral Governance Mechanisms in the Pandemic Instrument for One Health Action
Authors: Palkovits Michèle , Van Katwyk Susan Rogers , Hoffman Steven J. 
Published: March 2023

AbstractDespite recognition of the health threat posed at the human-animal-environment interface long ago, One Health has yet to be meaningfully integrated into global pandemic prevention, preparedness, and response. With the negotiation of the forthcoming pandemic instrument under the auspices of the World Health Organization (WHO) — which is inherently restricted by its own constitutional mandate of human health — One Health risks being sidelined once again. Genuine integration of a One Health approach into this treaty will require the institutionalization of formal One Health coordination mechanisms.
Turkey and African agency: the role of Islam and commercialism in Turkey's Africa policy
Authors: Süsler Buğra , Alden Chris 
Published: March 2023

AbstractThe concept of ‘agency’ and its role in capturing the dynamics between Africa and external actors feature increasingly in the African IR scholarship. Over the past decade, Turkey has become an increasingly prominent actor in Africa, strengthening political, cultural and economic ties with African states and providing humanitarian aid and development assistance. In this paper, we examine Turkey's relationship with Africa from the point of view of African agency and ask ‘How much and what kind of agency can we identify by examining the way in which Turkey approaches African states?’ The conventional understanding of the concept of African agency defines it in materialist terms and emphasises its transactional nature; it does not adequately explain incidents of enhanced outcomes for Africans in their relationship with Turkey. We argue that an under-examined aspect and a vital source of African agency lies within the discourses of Turkish policy which provide an enabling source of policy space for negotiation for Africans. We demonstrate that the notion of Muslim kinship in Turkish discourses not only distinguishes Turkey from most of the other external powers engaging with the continent but also enables African interlocutors to negotiate enhanced outcomes.