bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology and nomogram of pediatric and young adulthood osteosarcoma patients with synchronous lung metastasis: A SEER analysis
Authors: Liu Tao , Cui Lin , He Zongyun , Chen Zhe , Tao Haibing , Yang Jin 
Published: July 2023

Background
Patients with osteosarcoma and synchronous lung metastasis (SLM) have poor survival. This study aimed to explore the epidemiology data and construct a predictive nomogram to identify cases at risk of SLM occurrence among pediatric and young adulthood osteosarcoma patients.

Methods
All data were extracted from Surveillance, Epidemiology, and End Results 17 registries. The age-standardized incidence rate (ASIR) and annual percentage change was evaluated, and reported for the overall population and by age, gender, race, and primary site. Univariate and multivariate logistic regression analyses were used to identify risk factors associated with SLM occurrence, then significant factors were used to develop the nomogram. The area under the receiver operating characteristic curve (AUC) and calibration curve were used to evaluated the predictive power of the nomogram. Survival analysis was assessed by the Kaplan-Meier method and the log-rank test. Multivariate Cox analysis was used to determine the prognostic factors.

Results
A total of 278 out of 1965 patients (14.1%) presented with SLM at diagnosis. The ASIR increased significant from 0.46 to 0.66 per 1,000,000 person-years from year 2010 to 2019, with an annual percentage change of 3.5, mainly in patients with age 10–19 years, male and appendicular location. All patients were randomly assigned into train cohort and validation cohort with a spilt of 7:3. In the train cohort, higher tumor grade, bigger tumor size, positive lymph nodes and other site-specific metastases (SSM) were identified as significant risk factors associated with SLM occurrence. Then a nomogram was developed based on the four factors. The AUC and calibration curve in both train and validation cohorts demonstrated that the nomogram had moderate predictive power. The median cancer-specific survival was 25 months. Patients with age 20–39 years, male, positive lymph nodes, other SSM were adverse prognostic factors, while surgery was protective factor.

Conclusions
This study performed a comprehensive analysis regarding pediatric and young adulthood osteosarcoma patients had SLM. A visual, clinically operable, and easy-to-interpret nomogram model was developed for predicting the risk of SLM, which could be used in clinic and help clinicians make better decisions.
The Media Environment of Political Thought: Rousseau, Marx, and the Politics of Selfies, Asaf Y. Shamis (2017)
Authors: Fallon Peter K. 
Published: July 2023

Review of: The Media Environment of Political Thought: Rousseau, Marx, and the Politics of Selfies, Asaf Y. Shamis (2017)
London: Lexington Books, 99 pp.,
ISBN 978-1-49853-293-8, h/bk, $72.11
ISBN 978-1-49853-295-2, p/bk, $40.78
ISBN 978-1-49853-293-8, e-book, $38.94
New Media and the Artaud Effect, Jay Murphy (2021)
Authors: Kerasovitis Konstantinos 
Published: July 2023

Review of: New Media and the Artaud Effect, Jay Murphy (2021)
Cham: Palgrave Macmillan, 220 pp.,
ISBN 978-3-030-83487-6, h/bk, $109.99
ISBN 978-3-030-83490-6, p/bk, $79.99
ISBN 978-3-030-83488-3, e-book, $59.99
Diversity of fungi from marine inundated wood from the Bay of Fundy, Nova Scotia, Canada
Authors: Adams Sarah J. , Walker Allison K. 
Published: July 2023

Abstract
Marine fungi play an integral role in the decomposition of intertidal organic substrata but remain understudied in cold-water habitats including Atlantic Canada. Marine inundated wood from the intertidal zone was sampled from 30 sites along the Bay of Fundy coastline in Nova Scotia, Canada. Wood types studied included attached and loose intertidal wood, and driftwood. Emergent fungi were cultured and identified using ITS (internal transcribed spacers) rDNA barcoding. Two hundred and twenty cultures representing 86 fungi are reported. Sixty-one fungi were new records for the Bay of Fundy, 41 are first records from the marine environment, and 19 fungi are potentially new to science. Fungi identified included eight obligate marine fungi, with the remaining fungi being facultatively marine. Eight ascomycetes were soft rot fungi; this ecological strategy for decaying woody material in cold-water marine environments is discussed. Historical records and roles of wood type and site on fungal colonization are discussed.
Clinical relevance of clonal hematopoiesis and its interference in cell-free DNA profiling of patients with gastric cancer
Authors: Lee Kwang Seob , Lee Choong-Kun , Kwon Soon Sung , Kwon Woo Sun , Park Sejung , Lee Seung-Tae , Choi Jong Rak , Rha Sun Young , Shin Saeam 
Published: July 2023

Abstract

Objectives
Clonal hematopoiesis (CH) is a condition in which healthy individuals have somatic mutations in hematopoietic stem cells. It has been reported with increased risk of hematologic malignancy and cardiovascular disease in the general population, but studies of Korean populations with comorbid disease entities are scarce.

Methods
White blood cells (WBCs) from patients with gastric cancer (GC) (n=121) were analyzed using a DNA-based targeted (531 genes) panel with customized pipeline designed to detect single nucleotide variants and small indels with low-allele-frequency of ≥0.2 %. We defined significant CH variants as having variant allele frequency (VAF) ≥2 % among variants found in WBCs. Matched cell-free DNA (cfDNA) samples were also analyzed with the same pipeline to investigate the false-positive results caused by WBC variants in cfDNA profiling.

Results
Significant CH variants were detected in 29.8 % of patients and were associated with age and male sex. The number of CH variants was associated with a history of anti-cancer therapy and age. DNMT3A and TET2 were recurrently mutated. Overall survival rate of treatment-naïve patients with stage IV GC was higher in those with CH, but Cox regression showed no significant association after adjustment for age, sex, anti-cancer therapy, and smoking history. In addition, we analyzed the potential interference of WBC variants in plasma cell-free DNA testing, which has attracted interest as a complementary method for tissue biopsy. Results showed that 37.0 % (47/127) of plasma specimens harbored at least one WBC variant. VAFs of interfering WBC variants in the plasma and WBC were correlated, and WBC variants with VAF ≥4 % in WBC were frequently detected in plasma with the same VAF.

Conclusions
This study revealed the clinical impact of CH in Korean patients and suggests the potential for its interference in cfDNA tests.
Platform regulation and “overblocking” – The NetzDG discourse in Germany
Authors: Pohlmann Jens , Barbaresi Adrien , Leinen Peter 
Published: July 2023

Abstract
This paper analyzes the internet policy discourse regarding the German Network Enforcement Act (NetzDG) in different media settings. We examine the conversation about this highly controversial anti-hate speech law on IT blogs, websites, and in daily German newspapers. We compare the positions brought forward in these different media environments concerning one of the most important topics within the discussion about the NetzDG, specifically the question of whether or not the law will result in censorship, limiting users’ freedom of expression. We employ pretrained transformer-based language models to detect and quantify recurring arguments in the debate.
Removal behavior of Zn and alkalis from blast furnace dust in pre-reduction sinter process
Authors: Zhao Guiqing , Li Ruoyan , Xing Xiangdong , Ju Jiantao , Li Xinyi , Zu Jian 
Published: July 2023

Abstract
In this study, iron concentrate and blast furnace dust were used as raw materials, and graphite was used as a reducing agent for mixing and briquetting. The briquettes were roasted in a high-temperature tube furnace at different temperatures and held for a certain time to simulate the pre-reduction sintering process. The effects of dust content, reduction time, and reduction temperature on the removal rate of zinc, potassium, and sodium and the metallization rate of the pre-reduction sintered products were investigated. The reduced briquettes were characterized by X-ray diffraction, scanning electron microscopy-energy dispersive spectroscopy, and flame atomic absorption spectroscopy to further explore the mechanisms of zinc, potassium, and sodium removal. The Zn removal rate and metallization rate increased gradually with the increase in dust content, reaching 97.57% and 87.14% at 30% dust content, respectively. Both K and Na removal rates reached a maximum of 83.57% and 94.78%, respectively, at 25% dust content. With the increase in reduction time and temperature, the removal rate of the three elements and the metallization rate gradually increased. When the briquettes with 20% blast furnace (BF) dust content were reduced at 1,200℃ for 20 min, the removal rates of zinc, potassium, and sodium reached 95.66%, 79.97%, and 91.49%, respectively, and the metallization rate reached 84.77%. It shows that the pre-reduction sintering process can effectively remove Zn, K, and Na from the BF dust and meet the requirements of subsequent BF production. The research results can provide some theoretical basis for industrial production.
The DEAD-box RNA helicase Dbp5 is a key protein that couples multiple steps in gene expression
Authors: Querl Luisa , Krebber Heike 
Published: July 2023

Abstract
Cell viability largely depends on the surveillance of mRNA export and translation. Upon pre-mRNA processing and nuclear quality control, mature mRNAs are exported into the cytoplasm via Mex67-Mtr2 attachment. At the cytoplasmic site of the nuclear pore complex, the export receptor is displaced by the action of the DEAD-box RNA helicase Dbp5. Subsequent quality control of the open reading frame requires translation. Our studies suggest an involvement of Dbp5 in cytoplasmic no-go-and non-stop decay. Most importantly, we have also identified a key function for Dbp5 in translation termination, which identifies this helicase as a master regulator of mRNA expression.
Multi-sensor remote sensing image alignment based on fast algorithms
Authors: Shu Tao 
Published: July 2023

Abstract
Remote sensing image technology to the ground has important guiding significance in disaster assessment and emergency rescue deployment. In order to realize the fast automatic registration of multi-sensor remote sensing images, the remote sensing image block registration idea is introduced, and the image reconstruction is processed by using the conjugate gradient descent (CGD) method. The scale-invariant feature transformation (SIFT) algorithm is improved and optimized by combining the function-fitting method. By this way, it can improve the registration accuracy and efficiency of multi-sensor remote sensing images. The results show that the average peak signal-to-noise ratio of the image processed by the CGD method is 25.428. The average root mean square value is 17.442. The average image processing time is 6.093 s. These indicators are better than the passive filter algorithm and the gradient descent method. The average accuracy of image registration of the improved SIFT registration method is 96.37%, and the average image registration time is 2.14 s. These indicators are significantly better than the traditional SIFT algorithm and speeded-up robust features algorithm. It is proved that the improved SIFT registration method can effectively improve the accuracy and operation efficiency of multi-sensor remote sensing image registration methods. The improved SIFT registration method effectively solves the problems of low accuracy and long time consumption of traditional multi-sensor remote sensing image fast registration methods. While maintaining high registration accuracy, it improves the image registration speed and provides technical support for a rapid disaster assessment after major disasters such as earthquakes and floods. And it has an important value for the development of the efficient post-disaster rescue deployment.
Rickets in proximal renal tubular acidosis: a case series of six distinct etiologies
Authors: Singhania Pankaj , Dhar Abhranil , Deshpande Aditya , Das Debaditya , Agrawal Neeti , Chakraborty Partha Pratim , Bhattacharjee Rana , Roy Ajitesh 
Published: July 2023

Abstract

Objectives
Proximal renal tubular acidosis (pRTA) is characterized by a defect in the ability of the proximal convoluted tubule to reabsorb bicarbonate. The biochemical hallmark of pRTA is hyperchloremic metabolic acidosis with a normal anion gap, accompanied by appropriate acidification of the urine (simultaneous urine pH <5.3). Isolated defects in bicarbonate transport are rare, and pRTA is more often associated with Fanconi syndrome (FS), which is characterized by urinary loss of phosphate, uric acid, glucose, amino acids, low-molecular-weight proteins, and bicarbonate. Children with pRTA may present with rickets, but pRTA is often overlooked as an underlying cause of this condition.

Case presentation
We report six children with rickets and short stature due to pRTA. One case was idiopathic, while the remaining five had a specific underlying condition: Fanconi-Bickel syndrome, Dent's disease, nephropathic cystinosis, type 1 tyrosinemia, and sodium-bicarbonate cotransporter 1-A (NBC1-A) defect.

Conclusions
Five of these six children had features of FS, while the one with NBC1-A defect had isolated pRTA.
Framework for identifying network attacks through packet inspection using machine learning
Authors: Shanker Ravi , Agrawal Prateek , Singh Aman , Bhatt Mohammed Wasim 
Published: July 2023

Abstract
In every network, traffic anomaly detection system is an essential field of study. In the communication system, there are various protocols and intrusions. It is still a testing area to find high precision to boost the correct distribution ratio. Many authors have worked on various algorithms such as simple classification, K-Means, Genetic Algorithm, and Support Vector Machine approaches, and they presented the efficiency and accuracy of these algorithms. In this article, we have proposed a feature extraction technique known as “k-means clustering,” which has its roots in signal processing and is employed to divide a set of n observations into k clusters, each of which has its origin from the observation with the closest mean. K-Means method is applied in this study to investigate the stream and its implementation and applications using Python and the dataset on the KDDcup99. The effectiveness of the outcome indicates the planned work’s efficiency in relation to other widely available alternatives. Apart from the applied method, a web-based framework is designed, which can inspect an actual network traffic packet for identifying network attacks. Instead of using a static file for testing the network attack, a web page-based solution uses database to collect and test the information. Real-time packet inspection is provided in the proposed work for identifying new attacks.
Forkhead Box P4 promotes the proliferation of cells in colorectal adenocarcinoma
Authors: Liu Aidong , Pang Jiuling , Xiong Guangyi , Liu Qi , Chen Liming 
Published: July 2023

Abstract

Objectives
Forkhead Box P4 (FOXP4) is a transcription factor that promotes tumor formation and progression. However, studies on its roles in colorectal adenocarcinoma (CRAC) and cell proliferation regulation are few to date. This work investigates the expression of FOXP4 in CRAC, explores the characteristic of FOXP4 in different clinicopathological features, and analyzes its regulation of cell proliferation.

Methods
The GEPIA database was used to predict the trend of FOXP4 expression in colon cancer and normal mucosa. Tumor tissue and normal paracancerous mucosal tissue were sampled from 64 cases diagnosed with CRAC and who were receiving radical surgery at Tianjin Hospital from January 2017 and December 2022. FOXP4 and proliferating cell nuclear antigen (PCNA) were detected by the immunohistochemistry EnVision method. The colon cancer cell lines SW480, HCT15, and SW620 and the normal colon cell line NCM460 were selected, and expression of FOXP4 was detected by the Western blot method. The siRNA-FOXP4 plasmid was synthesized and transfected with SW480 and HCT15 cell lines, respectively, to establish si-FOXP4 groups, and empty vector transfection group (NC-FOXP4) and blank control group (NC) was set up. The expression levels of FOXP4 and PCNA were detected by the Western blot method, while the cell proliferation activity was assessed using CCK-8. Normally distributed quantitative data were compared between two and more groups with ANOVA (SNK-based pairwise comparison), while intergroup enumeration data comparisons were performed through χ
2 test and assessed through linear correlation analysis.

Results
GEPIA-based prediction shows a potential rise in FOXP4 expression in colon cancer. The rate of positive FOXP4 expression is significantly higher in CRAC tissue than in normal mucosa (p<0.05). The difference in FOXP4 is statistically significant in the comparison of maximum tumor diameter and depth of invasion in CRAC (p<0.05) but not in the comparison of gender, age, degree of differentiation, tumor focus, tumor embolism, and lymph node metastasis (p>0.05). The expression levels of FOXP4 and PCNA in CRAC are positively correlated (p<0.05). FOXP4 expression is significantly higher in cell lines SW480, HCT15, and SW620 than in cell line NCM460. The cell proliferation activity and PCNA expression are significantly lower in si-FOXP4 group than in NC-FOXP4 and NC groups for cell lines SW480 and HCT15.

Conclusions
FOXP4 is highly expressed and has a proliferative effect on tumor cells in CRAC.
Freedom and Heteronomy in the Anthropocene
Authors: Stoner Alexander M. , Dahms Harry F. 
Published: July 2023

AbstractThe concept of the Anthropocene reflects a particular meaning of the “human” as it exists in society, and a specific understanding of freedom, which only became possible at the close of the twentieth century. Whereas Enlightenment thinkers such as Kant, Rousseau, and Adam Smith attempted to grasp the potential for humanity to be changed through society in a self-conscious process of attaining freedom, the “Age of Man” today appears entirely disconnected from human agency. Indeed, the Anthropocene is associated not with the flourishing of life but with the sixth mass extinction. Drawing insight from classical and contemporary critical theory, this paper seeks to explicate the emancipatory potential within the concept of the Anthropocene, and the ways in which this potential is blocked by material circumstances that masquerade as “freedom.”
Liberté et communauté en Islam
Authors: Triki Fathi 
Published: July 2023

Abstract
L’individu peine à émerger dans les sociétés musulmanes qui vivent toujours sous l’impérium de la communauté. La dignité du vivre-ensemble ne devient réelle que dans la mesure où l’individu se libère et choisit son mode de vie. La dignité implique la liberté et la liberté conduit à la dignité. La question est de savoir si l’islam est un obstacle à cette libération de l’individu et s’il englobe en son sein le communautarisme. Est-il vrai que l’Islam est une religion de l’identité, de la communauté et donc de l’exclusion de la dignité individuelle ?
Sport und Freiheit
Authors: Gebauer Gunter 
Published: July 2023

Abstract
In den letzten Jahren hat sich der internationale Sport so grundlegend gewandelt, dass er in Gefahr ist, seine historisch gewachsene Identität aufzugeben. Nicht seine bildliche Qualität, seine Intensität und Spannung haben sich verändert; sie haben im Gegenteil noch zugenommen. Auf einem anderen Feld haben sich Dinge ereignet, die dem Sport einen neuen Charakter geben. Doch diese Veränderungen gehören zu einem Ausschnitt der Wirklichkeit, der auf den Fernsehbildern und in den Kommentaren nicht erkennbar ist; für die meisten Zuschauer bleibt er unsichtbar.
Soft Paternalism and Freedom in the Age of Artificial Intelligence – Through the “tactfulness (融通無碍 Yuzu-Muge)” of 華厳学 Hua-Yan philosophy
Authors: Suzuki Shoko 
Published: July 2023

Abstract
Living in an era of technological innovations, we must understand and trust them to benefit from these new technologies. In this context, paternalism is renewed as the so-called “soft-” or “Libertarian paternalism”. How can we face it and ensure freedom in the vortex of wellmeaning advice and persuasion? This paper will discuss 1. the characteristics of freedom since the 18th century from the perspective of the Enlightenment discourse in Germany by Mendelssohn and Kant, 2. the conditions for freedom in the contemporary age of accelerating technological innovation, and 3. from trans-modernism, rethinking the dichotomy between otherness and autonomy, coercion and freedom, by the idea of 融通無碍 Yuzu-Muge, tactfulness in 華厳学 Hua-Yan Philosophy.
LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma
Authors: Alborzinia Hamed , Chen Zhiyi , Yildiz Umut , Freitas Florencio Porto , Vogel Felix C E , Varga Julianna Patricia , Batani Jasmin , Bartenhagen Christoph , Schmitz Werner , Büchel Gabriele , Michalke Bernhard , Zheng Jashuo , Meierjohann Svenja , Girardi Enrico , Espinet Elisa , Flórez Andrés F , dos Santos Ancely Ferreira , Aroua Nesrine , Cheytan Tasneem , Haenlin Julie , Schlicker Lisa , Xavier da Silva Thamara N , Przybylla Adriana , Zeisberger Petra , Superti‐Furga Giulio , Eilers Martin , Conrad Marcus , Fabiano Marietta , Schweizer Ulrich , Fischer Matthias , Schulze Almut , Trumpp Andreas , Friedmann Angeli José Pedro 
Published: July 2023

AbstractFerroptosis has emerged as an attractive strategy in cancer therapy. Understanding the operational networks regulating ferroptosis may unravel vulnerabilities that could be harnessed for therapeutic benefit. Using CRISPR‐activation screens in ferroptosis hypersensitive cells, we identify the selenoprotein P (SELENOP) receptor, LRP8, as a key determinant protecting MYCN‐amplified neuroblastoma cells from ferroptosis. Genetic deletion of LRP8 leads to ferroptosis as a result of an insufficient supply of selenocysteine, which is required for the translation of the antiferroptotic selenoprotein GPX4. This dependency is caused by low expression of alternative selenium uptake pathways such as system Xc−. The identification of LRP8 as a specific vulnerability of MYCN‐amplified neuroblastoma cells was confirmed in constitutive and inducible LRP8 knockout orthotopic xenografts. These findings disclose a yet‐unaccounted mechanism of selective ferroptosis induction that might be explored as a therapeutic strategy for high‐risk neuroblastoma and potentially other MYCN‐amplified entities.
Вплив спікання в умовах високих температур і тиску та механохімічного синтезу на кристалічну структуру монокарбідів TiC, ZrC, HfC
Authors: Білявина Н.М. , Туркевич В.З. , Курилюк А.М. , Стратійчук Д.А. , Наконечна О.І. , Когутюк П.П. , Стасюк Л.П. 
Published: July 2023

Методом рентгенівської дифракції вивчено фазовий склад продуктів HPHT спікання (7,7 ГПа, 1600—2450 °С) систем cBN—TiC—Al, cBN—ZrC—Al та cBN—HfC—Al (об’ємне співвідношення компонентів шихти 60 : 35 : 5). Встановлено, що твердофазні реакції в цих системах ініціюються за температур баротермічної обробки, вищих за 2000 °С, і спричинюють утворення боридів відповідного металу (MeB2) та AlN. На основі рентгеноструктурних розрахунків кристалічної структури окремих фазових складових показано, що за високих температур HPHT спікання бориди MeB2 розчиняють невелику кількість алюмінію, а вихідні монокарбіди MeC перетворюються в карбіди MeCʹ, які в дійсності являють собою тверді розчини Me1–xAlxC, що містять до ≈8, ≈7 та ≈6 ат. % Al для TiC, ZrC та HfC відповідно. Механізм накопичення алюмінію в металевій підґратці твердих розчинів Me1–xAlxC здійснюється через попереднє утворення в структурах вихідних карбідів MeC вакансій, кількість яких корелює зі значенням ентальпії утворення цих карбідів.