bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality associated with Omicron and influenza infections in France before and during the COVID-19 pandemic
Authors: Goldstein Edward 
Published: August 2023

Abstract
For many deaths associated with influenza and Omicron infections, those viruses are not detected. We applied previously developed methodology to estimate the contribution of influenza and Omicron infections to all-cause mortality in France for the 2014–2015 through the 2018–2019 influenza seasons, and the period between week 33, 2022 and week 12, 2023. For the 2014–2015 through the 2018–2019 seasons, influenza was associated with annual average of 15,654 (95% CI (13,013, 18,340)) deaths, while between week 33, 2022 and week 12, 2023, we estimated 7,851 (5,213, 10,463) influenza-associated deaths and 32,607 (20,794, 44,496) SARS-CoV-2 associated deaths. For many Omicron-associated deaths for cardiac disease, mental&behavioural disorders, and other causes, Omicron infections are not characterised as a contributing cause of death – for example, between weeks 33–52 in 2022, we estimated 23,983 (15,307, 32,620) SARS-CoV-2-associated deaths in France, compared with 12,811 deaths with COVID-19 listed on death certificate. Our results suggest the need for boosting influenza vaccination coverage in different population groups in France, and for wider detection of influenza infections in respiratory illness episodes (including pneumonia) in combination with the use of antiviral medications. For Omicron epidemics, wider detection of Omicron infections in persons with underlying health conditions is needed.
Understanding the impact of the COVID-19 pandemic response on GI infection surveillance trends in England, January 2020–April 2022
Authors: Love Nicola K. , Douglas Amy , Gharbia Saheer , Hughes Helen , Morbey Roger , Oliver Isabel , Smith Gillian E. , Elliot Alex J. 
Published: August 2023

Abstract
Stepwise non-pharmaceutical interventions and health system changes implemented as part of the COVID-19 response have had implications on the incidence, diagnosis, and reporting of other communicable diseases. Here, we established the impact of the COVID-19 outbreak response on gastrointestinal (GI) infection trends using routinely collected surveillance data from six national English laboratory, outbreak, and syndromic surveillance systems using key dates of governmental policy to assign phases for comparison between pandemic and historic data. Following decreases across all indicators during the first lockdown (March–May 2020), bacterial and parasitic pathogens associated with foodborne or environmental transmission routes recovered rapidly between June and September 2020, while those associated with travel and/or person-to-person transmission remained lower than expected for 2021. High out-of-season norovirus activity was observed with the easing of lockdown measures between June and October 2021, with this trend reflected in laboratory and outbreak systems and syndromic surveillance indicators. Above expected increases in emergency department (ED) attendances may have reflected changes in health-seeking behaviour and provision. Differential reductions across specific GI pathogens are indicative of the underlying routes of transmission. These results provide further insight into the drivers for transmission, which can help inform control measures for GI infections.
Toward a Social Bioethics Through Interpretivism: A Framework for Healthcare Ethics
Authors: Dougherty Ryan J. , Fins Joseph J. 
Published: August 2023

AbstractRecent global events demonstrate that analytical frameworks to aid professionals in healthcare ethics must consider the pervasive role of social structures in the emergence of bioethical issues. To address this, the authors propose a new sociologically informed approach to healthcare ethics that they term “social bioethics.” Their approach is animated by the interpretive social sciences to highlight how social structures operate vis-à-vis the everyday practices and moral reasoning of individuals, a phenomenon known as social discourse. As an exemplar, the authors use social bioethics to reframe common ethical issues in psychiatric services and discuss potential implications. Lastly, the authors discuss how social bioethics illuminates the ways healthcare ethics consultants in both policy and clinical decision-making participate in and shape broader social, political, and economic systems, which then cyclically informs the design and delivery of healthcare.
‘Dance is a disease for us’: dancing through the night as a threat to moral order in urbanizing Estonia
Authors: Leivategija Karin 
Published: August 2023

AbstractThis article explores social dancing as the setting for moral struggles related to the urban night. Based on analysis of Estonian-language newspapers, I look at the historical context and expressed viewpoints linked with nocturnal public dance events in Estonian cities from 1880 to 1940. The established moral order was endangered by those staying out dancing late into the night. In the context of the multinationalism of urban areas and the national emancipation movement of the ethnic Estonian population, I investigate the transgressions and hazards that night dancing was perceived to bring, most significantly, threat to productivity, health and virtue.
Bilingual Abstract Semantic Associative Network Training (BAbSANT): A Russian–English case study
Authors: Gray Teresa , Palevich Julia , Sandberg Chaleece 
Published: August 2023

AbstractBAbSANT (Bilingual Abstract Semantic Associative Network Training) is a novel, theoretically motivated approach to anomia therapy for bilingual persons with aphasia (BPWA). We report on a Russian-dominant, Russian–English BPWA, who was trained on abstract English and Russian words. We hypothesized both within- and cross-language generalization when the non-dominant language was trained, and only within-language generalization when the dominant language was trained. We also hypothesized that cross-language generalization is modulated by nonverbal cognitive control. Results revealed that when English abstract words were trained, within-language generalization to concrete words and cross-language generalization to Russian abstract words was observed, confirming our first hypothesis. However, our second hypothesis was not confirmed. When Russian was trained, direct effects of treatment and within- or cross-language generalization effects were not observed. Our third hypothesis was confirmed. Results from cognitive control tasks from this individual suggest a role of nonverbal cognitive control on cross-language treatment outcomes.
Nutrition literacy status and its association with adherence to the Mediterranean diet, anthropometric parameters and lifestyle behaviours among early adolescents
Authors: Yurtdaş Depboylu Gamze , Kaner Gülşah , Süer Melisa , Kanyılmaz Mesude , Alpan Duygu 
Published: August 2023

AbstractObjective:To evaluate nutrition literacy status and its association with adherence to the Mediterranean diet (MD), anthropometric parameters and lifestyle behaviours among early adolescents.Design:This is a cross-sectional study. Nutrition literacy was evaluated using the ‘Adolescent Nutrition Literacy Scale’. Dietary intake was assessed by 24-h food recall. The ‘Mediterranean Diet Quality Index’ was used to evaluate adolescents’ adherence to the MD. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ). Body weight, height, waist, hip and neck circumference were measured.Setting:Four secondary schools in İzmir, TürkiyeParticipants:The study included 1074 secondary school students.Results:Adolescents’ nutrition literacy was at a moderate level. Nutrition literacy scores were significantly lower in those who skip main meals. Adolescents with high nutrition literacy had higher intakes of fibre, protein, protein, Ca, K, Mg, P, vitamin C, folate and Fe intake than those with low and moderate nutrition literacy (P < 0·05). According to IPAQ, active adolescents had higher nutrition literacy scores than inactive adolescents. There was no significant difference in BMI and anthropometric measurements of the adolescents according to their nutrition literacy level. Linear regression analysis showed that each unit increase in nutrition literacy increased adherence to the MD by 0·286 points (β = 0·286) and decreased total screen time by 0·182 points (β = –0·182).Conclusions:These findings showed that nutrition literacy among early adolescents was not optimal, and a higher nutrition literacy score was significantly associated with higher MD adherence, and healthy eating habits and lifestyle behaviours.
Response of Ecosystem Productivity to High Vapor Pressure Deficit and Low Soil Moisture: Lessons Learned From the Global Eddy‐Covariance Observations
Authors: Xu Shiqin , Gentine Pierre , Li Lingcheng , Wang Lixin , Yu Zhongbo , Dong Ningpeng , Ju Qin , Zhang Yuliang 
Published: August 2023

AbstractAlthough there is mounting concern about how high vapor pressure deficit (VPD) and low soil moisture (SM) affect ecosystem productivity, their relative importance is still under debate. Here, we comprehensively quantified the relative impacts of these two factors on ecosystem gross primary production (GPP) using observations from a global network of eddy‐covariance towers and two approaches (sensitivity analysis and linear regression model). Both approaches agree that a higher percentage of sites experience GPP reduction from high VPD than from low SM over the growing season. However, the constraint of high VPD and low SM on GPP reduction is tightly linked with climates and plant functional types. Humid and mesic ecosystems including forests and grasslands are dominated by VPD, while the semi‐arid and arid ecosystems including shrublands and savannas are dominated by SM. The varying dominant role of these two factors on GPP is closely related to plant stomatal behavior, as predicted by a stomatal conductance model. Additionally, we highlight the non‐linear impact of SM on GPP during droughts and the possible underestimation of the SM effects for deep‐rooted plants when only using surface‐layer SM. Our results shed light on a better understanding of the impacts of VPD and SM on vegetation productivity, with important implications for modeling the response and feedback of ecosystem dynamics to current and future climates.
Perturbations of JUICE/JDC Ion Measurements Caused by Spacecraft Charging in the Jovian Magnetosphere and the Ionosphere of Ganymede
Authors: Bochet M. , Bergman S. , Holmberg M. K. G. , Wieser M. , Wieser G. Stenberg , Wittmann P. , Gourinat Y. , Imhof C. , Barabash S. 
Published: August 2023

AbstractSpacecraft charging is a well‐known effect that occurs when a spacecraft is located in a charged environment such as plasma. In this process, the surface of the spacecraft acquires an electrostatic potential through the accumulation and emission of positive and negative charges. In addition to causing severe electrostatic discharges, it also significantly affects low‐energy particle measurements performed by instruments onboard the spacecraft as it causes a change in energy and a distortion of the Field Of View (FOV) of the instrument by modifying the trajectory of measured particles. Spacecraft charging is therefore an important aspect to consider for Jovian plasma Dynamics and Composition analyzer (JDC), an instrument which aims to perform cold plasma measurements around the Galilean moons onboard JUpiter ICy moons Explorer (JUICE). In this study we use SPIS to perform simulations to study the FOV distortion of JDC for positive ions caused by spacecraft charging in two environments of the JUICE mission: the ionosphere of Ganymede and the Jovian magnetosphere. We show that the resulting distortion of the instrument FOV is highly space dependent and varies in shape and intensity from a pixel to another. However, we show that in both environments the complexity of the interactions between measured positive ions and the spacecraft can be decomposed and described as a superposition of a finite number of elementary interactions (i.e., modes). We show that each mode is caused by a specific element of the spacecraft and leads to a characteristic distortion of the instrument FOV. This study constitutes a first step toward necessary spacecraft potential corrections of the measurements performed by JDC.
Lightning Evolution in Hailstorms From the Geostationary Lightning Mapper Over the Contiguous United States
Authors: Ni Xiang , Huang Fuxiang , Hui Wen , Xiao Hongyi 
Published: August 2023

AbstractAs two metrics that depict convection features, lightning and hail are generated through different physical mechanisms but are related. The Geostationary Lightning Mapper (GLM) provides a unique approach to monitoring and studying the continual evolution of lightning in hailstorms. In this study, 3 years of GLM observations were used to analyze the lightning evolution in hailstorms over the contiguous United States. The lightning rate had one peak at −2 min (relative to the hail occurrence time). The GLM lightning rates of large hail were lower than those of small hail in the hail occurrence time, but larger in the grids 0.2° west and east of the central grid. The maximum lightning rate grid generally moved southeastward. Observations of WWLLN confirmed these results but also highlighted differences, such as the high ratio between the WWLLN and GLM lightning rates around hail occurrence time. The events per flash and flash duration/area/energy generally showed opposite variations with lightning rate, and their low values were accompanied by high lightning rate and low detection efficiency of GLM relative to WWLLN. Furthermore, if the regional event rate was used in the lightning jump (LJ) algorithm, LJs preceded 94% of the hail reports, and the mean lead time reached 33 min. These results provide new insights into lightning features in hailstorms and verify the performance of the GLM in studying and monitoring hailstorms.
A randomized controlled trial investigating the effect of liraglutide on self-reported liking and neural responses to food stimuli in participants with obesity
Authors: Coppin Géraldine , Muñoz Tord David , Pool Eva R. , Locatelli Loïc , Achaibou Amal , Erdemli Asli , León Pérez Laura , Wuensch Lavinia , Cereghetti Donato , Golay Alain , Sander David , Pataky Zoltan 
Published: August 2023

Abstract
Background/Objectives
Obesity is a complex condition and the mechanisms involved in weight gain and loss are not fully understood. Liraglutide, a GLP-1 receptor agonist, has been demonstrated to successfully promote weight loss in patients with obesity (OB). Yet, it is unclear whether the observed weight loss is driven by an alteration of food liking. Here we investigated the effects of liraglutide on food liking and the cerebral correlates of liking in OB.

Subjects/Methods
This study was a randomized, single-center, double-blind, placebo-controlled, parallel group, prospective clinical trial. 73 participants with OB and without diabetes following a multidisciplinary weight loss program, were randomly assigned (1:1) to receive liraglutide 3.0 mg (37.40 ± 11.18 years old, BMI = 35.89 ± 3.01 kg) or a placebo (40.04 ± 14.10 years old, BMI = 34.88 ± 2.87 kg) subcutaneously once daily for 16 weeks.

Interventions/Methods
We investigated liking during food consumption. Participants reported their hedonic experience while consuming a high-calorie food (milkshake) and a tasteless solution. The solutions were administered inside the scanner with a Magnetic Resonance Imaging (MRI)-compatible gustometer to assess neural responses during consumption. The same procedure was repeated during the pre- and post-intervention sessions.

Results
None of the effects involving the intervention factor reached significance when comparing liking between the pre- and post-intervention sessions or groups. Liking during food reward consumption was associated with the activation of the ventromedial prefrontal cortex (vmPFC) and the amygdala. The liraglutide group lost more weight (BMI post-pre = −3.19 ± 1.28 kg/m2) than the placebo group (BMI post-pre = −0.60 ± 1.26 kg/m2).

Conclusions
These results suggest that liraglutide leads to weight loss without self-report or neural evidence supporting a concomitant reduction of food liking in participants with OB.
LZTR1 deficiency exerts high metastatic potential by enhancing sensitivity to EMT induction and controlling KLHL12-mediated collagen secretion
Authors: Abe Taiki , Kanno Shin-ichiro , Niihori Tetsuya , Terao Miho , Takada Shuji , Aoki Yoko 
Published: August 2023

AbstractLeucine zipper-like transcriptional regulator 1 (LZTR1), a substrate adaptor of Cullin 3 (CUL3)-based E3 ubiquitin ligase, regulates proteostasis of the RAS subfamily. Mutations in LZTR1 have been identified in patients with several types of cancer. However, the role of LZTR1 in tumor metastasis and the target molecules of LZTR1, excluding the RAS subfamily, are not clearly understood. Here, we show that LZTR1 deficiency increases tumor growth and metastasis. In lung adenocarcinoma cells, LZTR1 deficiency induced the accumulation of the RAS subfamily and enhanced cell proliferation, invasion, and xenograft tumor growth. Multi-omics analysis to clarify the pathways related to tumor progression showed that MAPK signaling, epithelial-mesenchymal transition (EMT), and extracellular matrix (ECM) remodeling-related gene ontology terms were enriched in LZTR1 knockout cells. Indeed, LZTR1 deficiency induced high expression of EMT markers under TGF-β1 treatment. Our search for novel substrates that interact with LZTR1 resulted in the discovery of a Kelch-like protein 12 (KLHL12), which is involved in collagen secretion. LZTR1 could inhibit KLHL12-mediated ubiquitination of SEC31A, a component of coat protein complex II (COPII), whereas LZTR1 deficiency promoted collagen secretion. LZTR1-RIT1 and LZTR1-KLHL12 worked independently regarding molecular interactions and did not directly interfere with each other. Further, we found that LZTR1 deficiency significantly increases lung metastasis and promotes ECM deposition around metastatic tumors. Since collagen-rich extracellular matrix act as pathways for migration and facilitate metastasis, increased expression of RAS and collagen deposition may exert synergistic or additive effects leading to tumor progression and metastasis. In conclusion, LZTR1 deficiency exerts high metastatic potential by enhancing sensitivity to EMT induction and promoting collagen secretion. The functional inhibition of KLHL12 by LZTR1 provides important evidence that LZTR1 may be a repressor of BTB-Kelch family members. These results provide clues to the mechanism of LZTR1-deficiency carcinogenesis.
Neutrophil extracellular traps contribute to immunothrombosis formation via the STING pathway in sepsis-associated lung injury
Authors: Zhu Shuainan , Yu Ying , Qu Mengdi , Qiu Zhiyun , Zhang Hao , Miao Changhong , Guo Kefang 
Published: August 2023

AbstractNeutrophil extracellular traps (NETs) are involved in the activation and dysfunction of multiple overlapping and interacting pathways, including the immune response to injury, inflammation, and coagulation, which contribute to the pathogenesis of sepsis-induced acute lung injury (SI-ALI). However, how NETs mediate the relationship between inflammation and coagulation has not been fully clarified. Here, we found that NETs, through stimulator of interferon genes (STING) activation, induced endothelial cell damage with abundant production of tissue factor (TF), which magnified the dysregulation between inflammatory and coagulant responses and resulted in poor prognosis of SI-ALI model mice. Disruption of NETs and inhibition of STING improved the outcomes of septic mice and reduced the inflammatory response and coagulation. Furthermore, Toll-like receptor 2 (TLR2) on the surface of endothelial cells was involved in the interaction between NETs and the STING pathway. Collectively, these findings demonstrate that NETs activate the coagulant cascade in endothelial cells in a STING-dependent manner in the development of SI-ALI.
Magnetoactive microlattice metamaterials with highly tunable stiffness and fast response rate
Authors: Zhang Wenqiang , Zhou Jingzhuo , Jia Yanwen , Chen Juzheng , Pu Yiru , Fan Rong , Meng Fanling , Ge Qi , Lu Yang 
Published: August 2023

AbstractActive metamaterials with shapes or mechanical properties that can be controlled remotely are promising candidates for soft robots, flexible electronics, and medical applications. However, current active metamaterials often have long response times and short ranges of linear working strains. Here, we demonstrate magnetoactive microlattice metamaterials constructed from 3D-printed, ultra-flexible polymer shells filled with magnetorheological (MR) fluid. Under compressive stress, the magnetorheological fluid develops hydrostatic pressure, allowing for a linear compression strain of more than 30% without buckling. We further show that under a relatively low magnetic field strength (approximately 60 mT), the microlattices can become approximately 200% stiffer than those in a relaxed state, and the energy absorption increases ~16 times. Furthermore, our microlattices showed an ultra-low response time with “field on” and “field off” times of ~200 ms and ~50 ms, respectively. The ability to continuously tune the mechanical properties of these materials in real time make it possible to modulate stress‒strain behavior on demand. Our study provides a new route toward large-scale, highly tunable, and remotely controllable metamaterials with potential applications in wearable exoskeletons, tactile sensors, and medical supports.
Single-cell lipidomics enabled by dual-polarity ionization and ion mobility-mass spectrometry imaging
Authors: Zhang Hua , Liu Yuan , Fields Lauren , Shi Xudong , Huang Penghsuan , Lu Haiyan , Schneider Andrew J. , Tang Xindi , Puglielli Luigi , Welham Nathan V. , Li Lingjun 
Published: August 2023

AbstractSingle-cell (SC) analysis provides unique insight into individual cell dynamics and cell-to-cell heterogeneity. Here, we utilize trapped ion mobility separation coupled with dual-polarity ionization mass spectrometry imaging (MSI) to enable high-throughput in situ profiling of the SC lipidome. Multimodal SC imaging, in which dual-polarity-mode MSI is used to perform serial data acquisition runs on individual cells, significantly enhanced SC lipidome coverage. High-spatial resolution SC-MSI identifies both inter- and intracellular lipid heterogeneity; this heterogeneity is further explicated by Uniform Manifold Approximation and Projection and machine learning-driven classifications. We characterize SC lipidome alteration in response to stearoyl-CoA desaturase 1 inhibition and, additionally, identify cell-layer specific lipid distribution patterns in mouse cerebellar cortex. This integrated multimodal SC-MSI technology enables high-resolution spatial mapping of intercellular and cell-to-cell lipidome heterogeneity, SC lipidome remodeling induced by pharmacological intervention, and region-specific lipid diversity within tissue.