bluuebunny/crossref_metadata_2025_split huggingface dataset:
Argentine consensus recommendations for lung cancer screening programmes: a RAND/UCLA-modified Delphi study
Authors: Boyeras Iris , Roberti Javier , Seijo Mariana , Suárez Verónica , Morero José Luis , Patané Ana Karina , Kaen Diego , Lamot Sebastián , Castro Mónica , Re Ricardo , García Artemio , Vujacich Patricia , Videla Alejandro , Recondo Gonzalo , Fernández-Pazos Alfonso , Lyons Gustavo , Paladini Hugo , Benítez Sergio , Martín Claudio , Defranchi Sebastián , Paganini Lisandro , Quadrelli Silvia , Rossini Sebastián , Garcia Elorrio Ezequiel , Sobrino Edgardo 
Published: February 2023

BackgroundLung cancer (LC) screening improves LC survival; the best screening method in terms of improving survival is low-dose CT (LDCT), outpacing chest X-ray and sputum cytology.MethodsA consensus of experts in Argentina was carried out to review the literature and generate recommendations for LC screening programmes. A mixed-method study was used with three phases: (1) review of the literature; (2) modified Delphi consensus panel; and (3) development of the recommendations. The Evidence to Decision (EtD) framework was used to generate 13 evaluation criteria. Nineteen experts participated in four voting rounds. Consensus among participants was defined using the RAND/UCLA method.ResultsA total of 16 recommendations scored ≥7 points with no disagreement on any criteria. Screening for LC should be performed with LDCT annually in the population at high-risk, aged between 55 and 74 years, regardless of sex, without comorbidities with a risk of death higher than the risk of death from LC, smoking ≥30 pack-years or former smokers who quit smoking within 15 years. Screening will be considered positive when finding a solid nodule ≥6 mm in diameter (or ≥113 mm3) on baseline LDCT and 4 mm in diameter if a new nodule is identified on annual screening. A smoking cessation programme should be offered, and cardiovascular risk assessment should be performed. Institutions should have a multidisciplinary committee, have protocols for the management of symptomatic patients not included in the programme and distribute educational material.ConclusionThe recommendations provide a basis for minimum requirements from which local institutions can develop their own protocols adapted to their needs and resources.
Long-term success after trabeculectomy in open-angle glaucoma: results of a retrospective cohort study
Authors: Wagner Felix Mathias , Schuster Alexander K , Kianusch Keywan , Stingl Julia , Pfeiffer Norbert , Hoffmann Esther M 
Published: February 2023

ObjectiveTo evaluate the long-term outcomes of trabeculectomy (TE) surgery in a large cohort with a minimum follow-up of 3 years.DesignRetrospective cohort study.SettingUniversity Eye Hospital, Germany.ParticipantsThree hundred and seventy-nine patients with open-angle glaucoma underwent TE with mitomycin C (MMC) between January 2013 and February 2017 with a minimal follow-up of 3 years. Eligible patients were identified via an electronic surgical case register.InterventionsAll patients had undergone TE with MMC following a set surgical protocol. To assess the influence of cataract surgery following TE, eyes which underwent cataract surgery at least 6 months after TE were matched 1:3 by sex and age to eyes who did not undergo cataract surgery during the follow-up period.Main outcome measuresPrimary outcome was the proportion of surgical success based on intraocular pressure (IOP), surgical complications, the need for revision surgery, loss of light perception and the need for additional pressure-lowering medication.ResultsThe mean follow-up time was 6 (±0.8, IQR: 5.4–6.5) years. Seventy-three per cent of eyes achieved qualified surgical success at the last follow-up (IOP≥5 mm Hg and ≤18 mm Hg, without surgical complications or complete loss of vision) but necessitated additional medical therapy, complete surgical success with no additional medical therapy was achieved in 69% of eyes. There was no significant difference in the success probability between eyes that had undergone cataract surgery after TE and those that had not (p=0.45).ConclusionsThe results demonstrate a high and stable success rate of TE after a mean follow-up time of approximately 6 years, that is, not affected by later cataract surgery.
Feasibility study of high-intensity interval training to reduce cardiometabolic disease risks in individuals with acute spinal cord injury
Authors: Maher Jennifer L , Whitmarsh Catherine , Smith Paula , Taylor Hazel , Fard Aram , Bilzon James 
Published: February 2023

IntroductionIndividuals ageing with spinal cord injury (SCI) experience an accelerated trajectory of diseases and disorders, such as cardiovascular disease and diabetes, that resemble those experienced with ageing alone. Currently, an evidence-based approach toward managing this problem does not exist and therefore the purpose of this study is to determine the feasibility of conducting a high-intensity exercise intervention in individuals with acute (<6 months postinjury) SCI to improve cardiometabolic health.Methods and analysisWe will conduct a single-centre, two parallel-arm, randomised feasibility study of a high-intensity interval training (HIIT) intervention in individuals with acute SCI. We will enrol 40 individuals (20 intervention, 20 control) with acute SCI attending inpatient rehabilitation at Salisbury District Hospital. Participants will be randomly allocated to the intervention group (HIIT) or control group for 18 weeks. Both groups will participate in standard care throughout the duration of the study. The HIIT group only will also perform supervised HIIT exercise on an arm cycle ergometer three times per week. Over the course of the intervention, most participants will be discharged from the hospital, and at this time, an arm cycle ergometer will be installed in their home and the intervention will transition into outpatient care. We will assess cardiorespiratory fitness, glycaemic control, lipid profile and body habitus as well as qualitative assessments of acceptability at weeks 0, 9 and 18 with the primary outcome being the feasibility of a full Randomised Controlled Trial (RCT).Ethics and disseminationThis study will inform a longer-term, definitive, multicentre RCT to establish the impact of this exercise intervention in maintaining the cardiometabolic health of patients during the acute phase following SCI. Results will be disseminated in different formats including peer-reviewed journal articles, conference presentations and internet media, to a wide audience including clinicians, researchers and individuals with SCI.Trial registration numberISRCTN57514022.
Health outcomes among offspring of US Coast Guard responders to the Deepwater Horizon oil spill, 2010–2011
Authors: Hall Clinton , Conlin Ava Marie S , Burrell Monica , Romano Celeste J , Bukowinski Anna T , Gumbs Gia R , Harville Emily W , Thomas Dana L , Denic-Roberts Hristina , Rusiecki Jennifer A 
Published: February 2023

ObjectiveTo evaluate the potential for adverse health outcomes among infants born to US Coast Guard (USCG) responders to the Deepwater Horizon (DWH) oil spill disaster.MethodsDepartment of Defense Birth and Infant Health Research programme data identified a cohort of singleton infants born 2010–2011 to USCG personnel in the DWH Oil Spill Coast Guard Cohort study. Infants were included if their military parent (‘sponsor’) responded to the oil spill during a selected reproductive exposure window (ie, 3 months preconception for male sponsors and periconception through pregnancy for female sponsors), or if their sponsor was a non-responder. χ2tests and multivariable log-binomial regression were used to compare the demographic and health characteristics of infants born to spill responders and non-responders.ResultsOverall, 1974 infants with a male sponsor (n=182 responder, n=1792 non-responder) and 628 infants with a female sponsor (n=35 responder, n=593 non-responder) in the DWH Oil Spill Coast Guard Cohort were identified. Health outcomes were similar among the offspring of male responders and non-responders. The frequency of any poor live birth outcome (ie, low birth weight, preterm birth or birth defect) was higher among infants born to female responders (17.1%, n=6) than non-responders (8.9%, n=53); the maternal age-adjusted association was suggestively elevated (risk ratio 1.93, 95% CI 0.89 to 4.16).ConclusionInfant health outcomes were comparable between the offspring of male USCG oil spill responders and non-responders. Findings were limited by the small number of infants identified, particularly among female responders, and should be interpreted with caution.
Sex-specific differences in the metabolic enzyme activity and transporter levels in mouse skeletal muscle during postnatal development
Authors: Takahashi Kenya , Kitaoka Yu , Hatta Hideo 
Published: February 2023

Although sex-associated differences in energy metabolism in adults are well-characterized, developmental sex-specific changes in skeletal muscle metabolism are largely unknown. This study investigated sex differences in high-energy phosphate, glycolytic, and mitochondrial enzyme activities and metabolite transporter protein levels in mouse skeletal muscles during the early postnatal period (day 10), post-weaning (day 28), sexual maturity (day 56), and adult life (day 140). No significant sex-specific differences were observed on days 10 and 28, except for glucose transporter (GLUT) 4 level. The hexokinase, phosphofructokinase, and lactate dehydrogenase activities of skeletal muscle were higher and the citrate synthase, cytochrome c oxidase, and β-hydroxyacyl-CoA dehydrogenase activities were lower in female mice than those in male mice on days 56 and 140. The GLUT4 and FAT/CD36 protein levels were higher and the monocarboxylate transporter 4 level was lower in the skeletal muscles of female mice than those of male mice, particularly on days 56 and 140. At 140 days of age, the respiratory exchange ratio during treadmill running (15 m/min, 60 min) was lower in females than that in males, despite no sex differences at rest. In summary, sex differences were not evident in the early postnatal and post-weaning periods but became apparent after the mice reached sexual maturity. These findings indicate that sexually mature animals are a better model for investigating sex differences, particularly in the context of studying energy metabolism in mice.
Muonic atom spectroscopy with microgram target material
Authors: Adamczak A. , Antognini A. , Berger N. , Cocolios T. E. , Deokar N. , Düllmann Ch. E. , Eggenberger A. , Eichler R. , Heines M. , Hess H. , Indelicato P. , Kirch K. , Knecht A. , Krauth J. J. , Nuber J. , Ouf A. , Papa A. , Pohl R. , Rapisarda E. , Reiter P. , Ritjoho N. , Roccia S. , Seidlitz M. , Severijns N. , von Schoeler K. , Skawran A. , Vogiatzi S. M. , Warr N. , Wauters F. 
Published: February 2023

AbstractMuonic atom spectroscopy–the measurement of the x rays emitted during the formation process of a muonic atom–has a long standing history in probing the shape and size of nuclei. In fact, almost all stable elements have been subject to muonic atom spectroscopy measurements and the absolute charge radii extracted from these measurements typically offer the highest accuracy available. However, so far only targets of at least a few hundred milligram could be used as it required to stop a muon beam directly in the target to form the muonic atom. We have developed a new method relying on repeated transfer reactions taking place inside a 100 bar hydrogen gas cell with an admixture of 0.25% deuterium that allows us to drastically reduce the amount of target material needed while still offering an adequate efficiency. Detailed simulations of the transfer reactions match the measured data, suggesting good understanding of the processes taking place inside the gas mixture. As a proof of principle we demonstrate the method with a measurement of the 2p-1s muonic x rays from a 5 $$\upmu \hbox {g}$$

μ
g

gold target.
Chaotic dynamics of a quantum Cournot duopoly game with heterogeneous expectations
Authors: Zhang Yuhuai , Yuan Jing , Zhang Yili 
Published: February 2023

On the basis of the bounded rationality and adaptive expectations, we investigate the dynamics of quantum Cournot duopoly game with heterogeneous players by using the Li et al. scheme. Further, we discuss the effect of quantum entanglement on local stability of the system. The results show that: (i) The special form of quantum Cournot duopoly game is the classical Cournot duopoly game, and the quantum Cournot duopoly game with naïve expectation is also a special form of quantum Cournot duopoly game with adaptive expectation. (ii) The increase or decrease of the stable region is dependent on the degree of quantum entanglement. It is related to the difference of relative marginal cost. (iii) The numerical simulation reveals the complexity characteristics of quantum dynamic Cournot game system through the analysis of stability region, bifurcation, strange attractor and sensitivity to initial conditions, and shows the difference from the classical dynamic Cournot model.
Transform margin source–sink clastic deposystems
Authors: Cronin Bryan T. , Nemčok M. , Doran H. 
Published: February 2023

Abstract

Shelf to basin floor clastic-sediment-routing models for individual structural parts of a transform margin are presented. Using 3D and 2D seismic, gravity and well data from the Guyana, Coromandal, Romanche, Saint Paul and Zenith–Wallaby Perth margins as examples, and drawing from a wide range of analogues, four discrete tectonic segments are recognized as characteristic of all transform margins: (1) the transform margin
sensu stricto
; (2) the local pull-apart segment on the transform margin; (3) the margin segment developed from the narrow horsetail splaying off from the transform; and (4) the margin segment developed from the extensional end of the horsetail structure, although there are other transitional variants specific to each margin. The routing of clastic sediments varies markedly across these segments. The shelfal staging area varies in width between the segments, increasing in width between segments 1 and 4, with wider shelves (10–25 km) characterized by significant sediment sorting through longshore drift, and narrower segments (0–10 km) often fed directly from focused fluvio-deltaic systems. The overall deep-water slope gradient decreases from segments (1) to (4), with sediment runout distance from shelf to basin floor increasing. The seafloor topography along the margin is highly variable, with significant sand sequestration on slopes with intra-slope ramps and terraces found in segments (2)–(4), with rapid downslope transitions from tributary slope gullies to slope channel complexes and then ponded intra-slope frontal splay complexes on the intra-slope terraces. Mass-transport deposits (MTDs) are ubiquitous and found as either regional slope MTDs or local collapses of slope channel complex margins. Stratigraphic and/or combination traps are associated with the ramp–terrace transitions. Local sectors show pinned long-lived intra-slope channel complex and canyon development, with prominent long-lived intra-slope stacking of intra-slope sandbodies. The outboard basin-floor- or trough-confined deep-water frontal splays (lobes), and their head area erosion by slope-originated MTDs, are directly controlled by the deposystems of the inboard slope systems. The lateral and vertical evolution of deep-water slope architecture is directly controlled by the inherited seafloor topography, set up by the underpinning crustal fabric across the four segments.
[18F]FDG and [18F]FES PET/CT Imaging as a Biomarker for Therapy Effect in Patients with Metastatic ER+ Breast Cancer Undergoing Treatment with Rintodestrant
Authors: Iqbal Ramsha , Yaqub Maqsood , Bektas Huseyyin O. , Oprea-Lager Daniela E. , de Vries Elisabeth G.E. , Glaudemans Andor W.J.M. , Aftimos Philippe , Gebhart Géraldine , Beelen Andrew P. , Schuit Robert C. , Windhorst Albert D. , Boellaard Ronald , Menke-van der Houven van Oordt C. Willemien 
Published: February 2023

Abstract

Purpose:
PET with 16α-[18F]-fluoro-17β-estradiol ([18F]FES) allows assessment of whole body estrogen receptor (ER) expression. The aim of this study was to investigate [18F]-fluorodeoxyglucose ([18F]FDG) and [18F]FES PET/CT imaging for response prediction and monitoring of drug activity in patients with metastatic ER-positive breast cancer undergoing treatment with the selective estrogen receptor downregulator (SERD) rintodestrant.

Experimental Design:
In this trial (NCT03455270), PET/CT imaging was performed at baseline ([18F]FDG and [18F]FES), during treatment and at time of progression (only [18F]FES). Visual, quantitative, and mutational analysis was performed to derive a heterogeneity score (HS) and assess tracer uptake in lesions, in relation to the mutation profile. The primary outcome was progression-free survival (PFS).

Results:
The HS and PFS in the entire group did not correlate (n = 16, Spearman's rho, P = 0.06), but patients with a low HS (&lt; 25.0%, n = 4) had a PFS of &gt; 5 months whereas patients with no [18F]FES uptake (HS 100.0%, n = 3) had a PFS of &lt; 2 months. [18F]FES uptake was not affected by estrogen receptor 1 (ESR1) mutations. On-treatment [18F]FES PET/CT scans showed no [18F]FES uptake in any of the baseline [18F]FES-positive lesions. At progression, [18F]FES uptake remained blocked in patients scanned ≤ 1–2 half-lives of rintodestrant whereas it restored in patients scanned ≥ 5 days after end of treatment.

Conclusions:
Absence of ER expression on [18F]FES PET is a predictor for no response to rintodestrant. [18F]FES uptake during treatment and at time of progression is useful to monitor the (reversible) effect of therapy and continued mode of action of SERDs.
See related commentary by Linden and Mankoff, p. 2015
Characterization of Cell-Free DNA Size Distribution in Osteosarcoma Patients
Authors: Udomruk Sasimol , Phanphaisarn Areerak , Kanthawang Thanat , Sangphukieo Apiwat , Sutthitthasakul Songphon , Tongjai Siripong , Teeyakasem Pimpisa , Thongkumkoon Patcharawadee , Orrapin Santhasiri , Moonmuang Sutpirat , Klangjorhor Jeerawan , Pasena Arnat , Suksakit Pathacha , Dissook Sivamoke , Puranachot Pitithat , Settakorn Jongkolnee , Pusadee Tonapha , Pruksakorn Dumnoensun , Chaiyawat Parunya 
Published: February 2023

Abstract

Purpose:
Cell-free DNA (cfDNA) analysis is a powerful tool for noninvasively predicting patient outcomes. We analyzed the size distribution of cfDNA and assessed its prognostic and diagnostic values in an osteosarcoma cohort.

Experimental Design:
The fragment size distribution and level of cfDNA were analyzed in 15 healthy donors and 50 patients with osteosarcoma using automated capillary electrophoresis. The prognostic performance of cfDNA size analysis was assessed using univariate and multivariable analyses. By performing whole-genome sequencing of matched cfDNA and osteosarcoma tissue samples, we investigated the correlation between the size and mutation profiles of cfDNA and the mutation concordance between cfDNA and paired tissue tumors.

Results:
The size of cfDNA fragments in patients with osteosarcoma was significantly shorter than in healthy donors, with the integrative analysis of size distribution and level of cfDNA achieving a high specificity and sensitivity of 100%. The short cfDNA fragment (150-bp cut-off) was an independent prognostic predictor in this osteosarcoma cohort [HR, 9.03; 95% confidence interval (CI), 1.13–72.20; P = 0.038]. Shortened cfDNA fragments were found to be a major source of mutations. Enrichment of cfDNA fragments with less than or equal to 150 bp by in silico size selection remarkedly improved the detection of copy-number variation signals up to 2.3-fold when compared with total cfDNA, with a higher concordance rate with matched osteosarcoma tissue.

Conclusions:
This finding demonstrated the potential of cfDNA size profiling in the stratification of poor prognostic patients with osteosarcoma. The short fragments of cfDNA are a promising source for boosting the detection of significant mutations in osteosarcoma.
See related commentary by Weiser et al., p. 2017
Single-Cell Transcriptomics Reveals Immune Reconstitution in Patients with R/R T-ALL/LBL Treated with Donor-Derived CD7 CAR-T Therapy
Authors: Chen Wei , Shi Hui , Liu Zhuojun , Yang Fan , Liu Jia , Zhang Leqiang , Wu Yajin , Xia Yuanshi , Ou Yuxuan , Li Ruiting , Zhang Ting , Zhang Jiecheng , Ke Xiaoyan , Hu Kai , Yu Jian 
Published: February 2023

AbstractPurpose:CD7 chimeric antigen receptor T (CAR-T) therapy has potent antitumor activity against relapsed/refractory (R/R) T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL), however, immune reconstitution after CAR-T remains largely unknown.Patients and Methods:An open-label phase I clinical trial (ChiCTR2200058969) was initiated to evaluate safety and efficacy of donor-derived CD7 CAR-T cells in 7 R/R T-ALL/LBL patients. CAR-T cells were detected by flow cytometry and PCR. Cytokine levels were quantified by cytometric bead arrays. Single-cell RNA sequencing (scRNA-seq) was adopted to profile immune reconstitution.Results:Optimal complete remission (CR) was 100% on day 28, and median followed-up time was 4 months. Leukopenia, thrombocytopenia, and neutropenia were observed in 6 patients, and infections occurred in 5 patients. Two patients died of serious infection and one died of a brain hemorrhage. CAR-T cells expanded efficiently in all patients. CD7+ T cells were eliminated in peripheral blood on day 11 after infusion, and CD7− T cells dramatically expanded in all patients. scRNA-seq suggested that immunologic activities of CD7− T cells were stronger than those of T cells before infusion due to higher expression levels of T-cell function-related pathways, and major characters of such CD7− T cells were activation of autoimmune-related pathways. Monocyte loss was found in 2 patients who died of serious infections, indicating the main cause of the infections after infusion. S100A8 and S100A9 were identified as potential relapse markers due to their notable upregulation in leukocyte lineage in relapsed patients versus non-relapse controls.Conclusions:Our data revealed cellular level dynamics of immune homeostasis of CD7 CAR-T therapy, which is valuable for optimizing the treatment of R/R T-ALL/LBL.
Ensuring Global Access to Cancer Medicines: A Generational Call to Action
Authors: Dare Anna J , Bayle Arnauld , Hatoqai Asma , Mungo Chemtai , Velilla Diego Gimenez , Soto-Perez-de-Celis Enrique , Gnangnon Freddy Houéhanou Rodrigue , Lim Melissa Siaw Han , Ralefala Tlotlo , Mushininga Venus Dadirai 
Published: February 2023

Summary:
Essential cancer treatments are not accessible, affordable, or available to patients who need them in many parts of the world. A new Access to Oncology Medicines (ATOM) Coalition, using public–private partnerships, aims to bring essential cancer medicines and diagnostics to patients in low- and lower middle-income countries.