bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Anticancer Effect of Temozolomide through Synergistic Combination with Diltiazem in Neuroblastoma (SH-SY5Y) Cell Line
Authors: KARADEMİR Mustafa , SURARDAMAR Saime 
Published: June 2023

Objective: This study aimed to assess the enhanced anticancer effect of Temozolomide (TMZ) through a synergistic combination with Diltiazem (DTZ) in the neuroblastoma cell line (SH-SY5Y).
Material and Methods: The SH-SY5Y neuroblastoma cell line was cultured in a DMEM medium. TMZ and DTZ stock solutions were prepared and diluted to obtain different concentrations. The XTT assay was performed to evaluate cell viability. Cells were treated with TMZ alone or with DTZ for 24 and 48 hours. Viability was measured using the XTT-formazan product, and statistical analysis was performed.
Results: The viability of neuroblastoma cells treated with TMZ alone and TMZ+DTZ combination was assessed. At 24 hours, TMZ showed no cytotoxic effect, while DTZ showed a low cytotoxic impact. At 48 hours, TMZ and TMZ+DTZ combination exhibited significant cytotoxic effects. The cytotoxic effects were concentration-dependent and time-dependent. DTZ alone showed significant cytotoxic effects on neuroblastoma cells at specific concentrations.
Conclusion: The study demonstrated that TMZ alone and combined with DTZ had a significant cytotoxic effect on neuroblastoma cells. The combination of TMZ and DTZ may enhance the anticancer effect of TMZ and overcome drug resistance in neuroblastoma treatment. DTZ, a P-glycoprotein inhibitor, could prevent the efflux of TMZ from cancer cells, increasing its concentration and effectiveness.
Mnemonic Ecologies
Authors: Pieck Sonja K. 
Published: June 2023

An exploration of the Green Belt conservation project between the former East and West Germanies and its relationship to emergent ecosystems, trauma, and memorialization.
The first book-length scholarly treatment of Germany's largest conservation project, the Green Belt, Mnemonic Ecologies by Sonja Pieck presents a new interdisciplinary approach: that effective restoration and conservation of wounded land must merge ecology with memory. Since the Cold War's end in 1989, German conservationists have transformed the once-militarized border between East and West Germany into an extensive protected area. Yet as forests, meadows, and wetlands replace fences, minefields, and guard towers, ecological recovery must reckon with the pain of the borderlands' brutal past. The lessons gained by conservationists here, Pieck argues, have profound practical and ethical implications far beyond Germany.
Can conservation help heal both ecological and societal wounds? How might conservation honor difficult socioecological pasts? Deeply researched and evocatively written, this beautiful, interdisciplinary investigation into the legacy of war and nature's resurgence blends environmental history, ethics, geography, and politics with ecology and memory studies. Amid our rampant biodiversity crisis, Mnemonic Ecologies shows why conservation must include humanized landscapes in its purview, thus helping to craft a new conservation ethos that is collaborative, empathetic, and more sensitive to the connections between humans and the places they inhabit.
No Heavenly Bodies
Authors: Evans Christine E. , Lundgren Lars 
Published: June 2023

The compelling and little-known history of satellite communications that reveals the Soviet and Eastern European roles in the development of its infrastructure.
Taking its title from Hannah Arendt's description of artificial earth satellites, No Heavenly Bodies explores the history of the first two decades of satellite communications. Christine E. Evans and Lars Lundgren trace how satellite communications infrastructure was imagined, negotiated, and built across the Earth's surface, including across the Iron Curtain. While the United States' and European countries' roles in satellite communications are well documented, Evans and Lundgren delve deep into the role the Soviet Union and other socialist countries played in shaping the infrastructure of satellite communications technology in its first two decades.
Departing from the Cold War binary and the competitive framework that has animated much of space historiography and telecommunications history, No Heavenly Bodies focuses instead on interaction, cooperation, and mutual influence across the Cold War divide.
Evans and Lundgren describe the expansion of satellite communications networks as a process of negotiation and interaction, rather than a simple contest of technological and geopolitical prowess. In so doing, they make visible the significant overlaps, shared imaginaries, points of contact and exchange, and negotiated settlements that determined the shape of satellite communications in its formative decades.
Playful Wearables
Authors: Buruk Oğuz , Dagan Ella , Isbister Katherine , Segura Elena Márquez , Tanenbaum Theresa Jean 
Published: June 2023

An expert introduction to the world of “playful wearables” and their design, with a wide range of engaging examples, case studies, and exercises.
This pioneering introduction to the world of wearable technology takes readers beyond the practical realm (think Fitbits, Apple Watches, and smartglasses) to consider another important side of the technology—the playful. Playful Wearables offers an engaging account of what “playful wearables” are, why they matter, how they work, how they're made, and what their future might hold. The book's authors draw on decades of experience in design, development, and research to offer real-world examples, exercises, and implications, showing how this kind of wearable tech can introduce an invaluable element of play into our everyday lives.
As wearable technology emerges in the ecology of costume and fashion, the authors consider its intimate connection to identity and culture. And they look at the ways in which playful wearables, when smoothly integrated into everyday social experiences, support social interaction. The book then moves on to the mechanics of playful wearables—from design strategies and frameworks to specific methods and game design patterns. All of these elements point to possibilities beyond the realm of games and dedicated play, as the value and uses of playful wearables in the larger world of self, society, and culture become ever more apparent.
The Abundant University
Authors: Smith Michael D. 
Published: June 2023

Why our current system of higher education is financially and morally unsustainable and how to address the crisis with the creative implementation of digital technologies.
For too long, our system of higher education has been defined by scarcity: scarcity in enrollment, scarcity in instruction, and scarcity in credentials. In addition to failing students professionally, this system has exacerbated social injustice and socioeconomic stratification across the globe. In The Abundant University, Michael D. Smith argues that the only way to create a financially and morally sustainable higher education system is by embracing digital technologies for enrolling, instructing, and credentialing students—the same technologies that we have seen create abundance in access to resources in industry after industry.
The Abundant University explains how we got our current system, why it's such an expensive, inefficient mess, and how a system based on exclusivity cannot foster inclusivity. Smith challenges the resistance to digital technologies that we have already seen among numerous institutions, citing the examples of faculty resistance toward digital learning platforms. While acknowledging the understandable self-preservation instinct of our current system of residential education, Smith makes a case for how technology can engender greater educational opportunity and create changes that will benefit students, employers, and society as a whole.
Demystifying the Academic Research Enterprise
Authors: Droegemeier Kelvin K. 
Published: June 2023

What next-generation scholars need to know in order to thrive, and how they can actively participate in shaping the academic research enterprise.
The academic research enterprise is highly complex, involving multiple sectors of society and a vast array of approaches. In Demystifying the Academic Research Enterprise, Kelvin K. Droegemeier shows next-generation scholars across all disciplines how to become more productive earlier in their career, as well as how to help shape the academic research enterprise. The topics covered include public perceptions of scholarly work and its use in policy; understanding the big picture of funding and national priorities as well as identifying funding sources; research methods; collecting data and materials; writing grant proposals; publishing results; ethical conduct; bias and peer review; intellectual property and compliance regulations; partnerships and collaboration; diversity, equity, and inclusion; and the future of research.
Droegemeier's two principal goals are to enhance and accelerate scholars' understanding of the academic research process and to democratize that understanding, particularly at institutions that traditionally are underrepresented or lack robust resources. While intended for undergraduate and graduate students, postdoctoral scholars, and early career faculty, Demystifying the Academic Research Enterprise is also relevant to mid-career and senior faculty, research administrators, funding organizations, congressional staff, policymakers, and the general public. Droegemeier places scholars in a broader national and international context—not as passive recipients of the existing system but as key actors who actively participate in helping to set priorities, determine policies, drive systemic change, and advance knowledge.
Programming Your GPU with OpenMP
Authors: Deakin Tom , Mattson Timothy G. 
Published: June 2023

The essential guide for writing portable, parallel programs for GPUs using the OpenMP programming model.
Today's computers are complex, multi-architecture systems: multiple cores in a shared address space, graphics processing units (GPUs), and specialized accelerators. To get the most from these systems, programs must use all these different processors. In Programming Your GPU with OpenMP, Tom Deakin and Timothy Mattson help everyone, from beginners to advanced programmers, learn how to use OpenMP to program a GPU using just a few directives and runtime functions. Then programmers can go further to maximize performance by using CPUs and GPUs in parallel—true heterogeneous programming. And since OpenMP is a portable API, the programs will run on almost any system.
Programming Your GPU with OpenMP shares best practices for writing performance portable programs. Key features include:
• The most up-to-date APIs for programming GPUs with OpenMP with concepts that transfer to other approaches for GPU programming.
• Written in a tutorial style that embraces active learning, so that readers can make immediate use of what they learn via provided source code.
• Builds the OpenMP GPU Common Core to get programmers to serious production-level GPU programming as fast as possible.
Additional features:
• A reference guide at the end of the book covering all relevant parts of OpenMP 5.2.
• An online repository containing source code for the example programs from the book—provided in all languages currently supported by OpenMP: C, C++, and Fortran.
• Tutorial videos and lecture slides.
May We Make the World?
Authors: Zoloth Laurie 
Published: June 2023

An in-depth look at genetic alteration in the natural world and the oppositions to it, seen through the case study of a gene drive for malaria.
May We Make the World? is an engaging reflection on the history, nature, goal, and meaning of using a new technological idea—CRISPR-based genetic engineering—to alter the genome of the mosquito that carries malaria. This technology, called a “gene drive,” can alter the sex ratio in Anopheles gambiae mosquitoes, the key vector for falciparum, the deadliest form of malaria. P. Falciparum kills 400,000 people a year, largely the poorest children in the world among them. In her sobering examination of the issue, Laurie Zoloth considers the leading ethical arguments for and against gene drives, explores the regulatory efforts that have emerged long in advance of the science, and considers the philosophical questions raised by the struggle to eliminate malaria.
The development of a gene drive for malaria will have far-reaching implications for it represents the first use of genetic engineering in the natural world and the first creation of a genetic variant intended to spread in the African wild beyond human control. Drawing on two decades of work, Zoloth brilliantly argues that we can understand the complex moral issues at stake only by carefully reflecting on the science, the nature of the local and global discourse about genetic engineering, and the long history of malaria, which—as it transformed from a worldwide disease to a tropical one—reshaped the world as we know it.
The Hidden Powers of Ritual
Authors: Shore Bradd 
Published: June 2023

An illuminating overview of the development, benefits, and importance of ritual in everyday life, written by a leading cognitive anthropologist.
The Hidden Powers of Ritual is an engaging introduction to ritual studies that presents ritual as an evolved form of human behavior of almost unimaginable significance to our species. Every day across the globe, people gather to share meals, brew caffeinated beverages, or honor their ancestors. In this book, Bradd Shore, a respected anthropologist, reaches beyond familiar “big-R” rituals to present life's humbler, overshadowed moments, exploring everything from the Balinese pelebon to baseball to family Zoom sessions in the age of Covid to the sobering reenactment rituals surrounding the Moore's Ford lynchings. In each ritual, Shore shows how our capacity to ritualize behavior is a remarkable part of the human story.
Encompassing both the commonly unlabeled “interaction rituals” studied by sociologists and the symbolically elaborated sacred rituals of religious studies, Shore organizes his conception around detailed case studies drawn from international research and personal experience, weaving scholarship with a memoir of a life encompassed by ritual. A probing exploration that matches breadth with accessibility, The Hidden Powers of Ritual is a provocative contribution to ritual theory that will appeal to a wide range of readers curious about why these unique repetitive acts matter in our lives.
TMEM200A is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer
Authors: Fang Fujin , Zhang Tiantian , Lei Huan , Shen Xiaobing 
Published: June 2023

Background
Gastric cancer (GC) is one of the most common malignant tumors in the digestive system. Several transmembrane (TMEM) proteins are defined as tumor suppressors or oncogenes. However, the role and underlying mechanism of TMEM200A in GC remain unclear.

Methods
We analyzed the expression of TMEM200A in GC. Furthermore, the influence of TMEM200A on survival of GC patients was evaluated. The correlations between the clinical information and TMEM200A expression were analyzed using chi-square test and logistic regression. Relevant prognostic factors were identified performing univariate and multivariate analysis. Gene set enrichment analysis (GSEA) was performed based on the TCGA dataset. Finally, we explore the relationship between TMEM200A expression and cancer immune infiltrates using CIBERSORT.

Results
TMEM200A was up-regulated in GC tissues than that in adjacent non-tumor tissues based on TCGA database. Meta-analysis and RT-qPCR validated the difference in TMEM200A expression. Kaplan-Meier curves suggested the increased TMEM200A had a poor prognosis in GC patients. The chi-square test and logistic regression analyses showed that the TMEM200A expression correlates significantly with T stage. Multivariate analysis showed that TMEM200A expression might be an important independent predictor of poor overall survival in GC patients. GSEA identified five immune-related signaling pathways and five tumor-related signaling pathways significantly enriched in the high TMEM200A expression phenotype pathway. Finally, we found CD8+ T cells is apparently decreased in high TMEM200A expression group. Conversely, eosinophils is increased in high expression group compared with low expression group.

Conclusion
TMEM200A is a potential prognostic biomarker and correlated with immune infiltrates in GC.
Study on the Impact of Season and Location on the Native Pastures’ Quality in West Timor, Indonesia
Authors: Jelantik I. Gusti N. , Malelak Gemini E. M. 
Published: June 2023

Aims: The objective of this experiment was to investigate the monthly changes of crude protein and NDF content of forages and the in vitro organic matter digestibility of forages obtained from native pastures in West Timor.
Place and Duration of Study: Native pastures were located in three districts of West Timor, Indonesia. The collected forage samples were determined for crude protein (CP) and neutral detergent fiber (NDF) in the laboratory of feed chemistry, the Faculty of Animal Husbandry, Marine and Fishery. The in vitro study was also conducted in the same laboratory. The study was conducted from December 2021 to October 2022.
Methodology: Pasture samples were taken from six native pastures in three districts, i.e. districts of Kupang, Timor Tengah Selatan and Timor Tengah Utara. In each pasture, as many as five 40x40 cm quadrants of forages were clipped bimonthly throughout the year at 5 cm from the soil. Forage was then dried and composited for each district and thereafter sub-sampled for chemical analyses. Forage samples were determined for crude protein and NDF content as well as in vitro organic matter digestibility.
Results: Results showed forage quality fluctuated with months. The CP content and IVOMD were highest (P<.05) during the beginning of the rainy season and the lowest during the late dry season. In contrast, forage NDF content increased (P<.05) from 64% during the early wet season to 71-77% during the late wet season and dry season. There was no significant difference (P>.05) in the nutritive quality of native pasture among different districts in Timor.
Conclusion: Pasture quality fluctuates with months and its pattern is comparable among districts.
A Review of the Impact of Homelessness on Mental Health
Authors: Anombem Odiaka Mark , Arisoyin Abimbola , Okereke Obiamaka Pamela , Okobi Okelue Edwards , Mamman Aisha , Salawu Mujeeb Adedeji , Oaikhena Ijeoma Omosede 
Published: June 2023

Background: Homelessness has become a complex issue with profound impacts on society. Social determinants like housing significantly impacts human well-being in numerous ways, ranging from physical safety to appropriate access to necessities such as healthy food options and medical care. This research seeks to delve deeper into understanding how being homeless can affect mental health outcomes.
Methodology: A literature review conducted following a systematic method was integral to our research process. We searched PubMed, PsycINFO, and Scopus, utilizing a combination of keywords related to homelessness, mental health, and their impact.
Results: The reviewed studies consistently highlighted the prevalence of mental health disorders among homeless individuals, ranging from depression, suicide, alcoholism, substance abuse, and Schizophrenia. The evidence highlights the complex relationship between homeless status and psychological well-being, noting that lack of secure housing can trigger and exacerbate mental illness.
Conclusion: This review emphasizes the significance of providing homeless individuals with essential mental health aid and secure housing accommodations cannot be underscored enough. By recognizing the relationship between homelessness and mental health, society can work towards implementing effective strategies that promote recovery and social inclusion for this vulnerable population.
High‐Density, Crosstalk‐Free, Flexible Electrolyte‐Gated Synaptic Transistors Array via All‐Photolithography for Multimodal Neuromorphic Computing
Authors: Yuan Li , Zhao Tingting , Dai Junshuai , Xue Longwei , Zhang Xudong , Peng Cong , Wen Pan , Liu Hai , Hu Hong , Chen Longlong , Xin Hanshen , Li Jun , Li Xifeng , Zhang Jianhua 
Published: January 2025

AbstractHigh‐density bio‐electrolyte‐gated synaptic transistors (BEGTs) array are promising for constructing neuromorphic computing architectures. Due to the bulk ion conductivity and the crack sensitivity of the electrolyte film, patterning the electrolyte is an indispensable route to prevent spatial crosstalk and improve the flexibility of the device array. However, the susceptibility of bio‐electrolyte to organic solvents poses challenges in developing reliable all‐photolithography techniques for fabricating scalable, patterned, and high‐density BEGTs array. This study introduces an all‐photolithography method that adopts a photo‐crosslinker‐enabled electrolyte to create a high‐density (11846 devices per cm2) multimodal BEGTs array. This array demonstrates essential neuromorphic behaviors without inter‐device crosstalk and maintains its flexibility, enduring 200 bending cycles at a 6 mm radius without significant performance degradation. Meanwhile, the BEGTs array exhibits multimodal synaptic behavior, not only successfully mimicking the biological visual memory system for sensing and processing images but also proving highly accurate in classifying handwritten digits, making it suitable for constructing neuromorphic computing systems. This work offers a dependable strategy for the scalable and stable fabrication of BEGTs array, providing valuable insights for advancing artificial neuromorphic systems.
Boosting Amino Acid Synthesis with WOx Sub‐Nanoclusters
Authors: Wu Guanzheng , Ma Zengying , Heil Tobias , Zhang Leting , Hu Wangcheng , Wu Guoqing , He Wenhui , Dai Lei , Huang Yucheng , Qin Qing 
Published: January 2025

AbstractThe conversion of nitrate‐rich wastewater and biomass‐derived blocks into high‐value products using renewably generated electricity is a promising approach to modulate the artificial carbon and nitrogen cycle. Here, a new synthetic strategy of WOx sub‐nanoclusters is reported and supported on carbon materials as novel efficient electrocatalysts for nitrate reduction and its coupling with α‐keto acids. In acidic solutions, the NH3‐NH2OH selectivity can also optimized by adjusting the potential, with the total FE exceeding 80% over a wide potential range. After introducing α‐keto acids, the WOx/D‐CB electrode achieves remarkable activity and selectivity toward C2‐C6 amino acids. For glycine and alanine, impressive FEs of 49.34% and 38.22% based on transitional metal oxides can be obtained, surpassing those of WOx nanoclusters with larger size. In situ analysis and mechanistic studies reveal the critical role of WOx sub‐nanoclusters in reducing the energy barriers of key steps in alanine synthesis. This work opens up new insights into the rational design of cluster catalysts to promote electrochemical amino acid synthesis.