bluuebunny/crossref_metadata_2025_split huggingface dataset:
ATR inhibition augments the efficacy of lurbinectedin in small‐cell lung cancer
Authors: Schultz Christopher W , Zhang Yang , Elmeskini Rajaa , Zimmermann Astrid , Fu Haiqing , Murai Yasuhisa , Wangsa Darawalee , Kumar Suresh , Takahashi Nobuyuki , Atkinson Devon , Saha Liton Kumar , Lee Chien‐Fei , Elenbaas Brian , Desai Parth , Sebastian Robin , Sharma Ajit Kumar , Abel Melissa , Schroeder Brett , Krishnamurthy Manan , Kumar Rajesh , Roper Nitin , Aladjem Mirit , Zenke Frank T , Ohler Zoe Weaver , Pommier Yves , Thomas Anish 
Published: July 2023

AbstractSmall‐cell lung cancer (SCLC) is the most lethal type of lung cancer. Specifically, MYC‐driven non‐neuroendocrine SCLC is particularly resistant to standard therapies. Lurbinectedin was recently approved for the treatment of relapsed SCLC, but combinatorial approaches are needed to increase the depth and duration of responses to lurbinectedin. Using high‐throughput screens, we found inhibitors of ataxia telangiectasia mutated and rad3 related (ATR) as the most effective agents for augmenting lurbinectedin efficacy. First‐in‐class ATR inhibitor berzosertib synergized with lurbinectedin in multiple SCLC cell lines, organoid, and in vivo models. Mechanistically, ATR inhibition abrogated S‐phase arrest induced by lurbinectedin and forced cell cycle progression causing mitotic catastrophe and cell death. High CDKN1A/p21 expression was associated with decreased synergy due to G1 arrest, while increased levels of ERCC5/XPG were predictive of increased combination efficacy. Importantly, MYC‐driven non‐neuroendocrine tumors which are resistant to first‐line therapies show reduced CDKN1A/p21 expression and increased ERCC5/XPG indicating they are primed for response to lurbinectedin–berzosertib combination. The combination is being assessed in a clinical trial NCT04802174.
Overexcitability Berdasar Keberbakatan
Authors: Kosasih Ismawati , Suralaga Fadhilah , Maslihah Sri 
Published: July 2023

Setiap anak memiliki karakteristik yang berbeda. Setiap pendidik harus memahami perbedaan karakteristik siswanya agar dapat menyiapakan metode pembelajaran yang sesuai sehingga tujuan pembelajaran dapat dicapai secara optimal. Penelitian ini dilakukan untuk menguji apakah siswa berbakat memiliki karakteristik overexcitability dengan cara membandingkan skor overexcitability antara siswa berbakat dan siswa regular. Sampel yang dilibatkan dalam penelitian ini adalah 173 siswa di salah satu SMAN di Tangerang Selatan yang merupakan siswa program akselerasi dan regular. Overexcitability diukur menggunakan Instrumen hasil adaptasi dari Overexcitability Questionnaire II (OEQ II). Analisis data yang digunakan adalah independent sample t-test. Hasil penelitian ini menunjukkan bahwa H0 ditolak (Sig. 0.001, p 0.05)yang berarti siswa berbakat memiliki skor overexcitability yang lebih tinggi dari siswa regular. Namun, yang signifikan hanya psychomotor (Sig. 0.041, p 0.05), intellectual (Sig. 0.009, p 0.05), dan imaginational overexcitability (Sig. 0.000, p 0.05).Every child has different characteristics. Each educator must understand the different characteristics of his students in order to be able to prepare appropriate learning methods so that learning objectives can be achieved optimally. This research was conducted to test whether gifted students have overexcitability characteristics by comparing overexcitability scores between gifted students and regular students. Sample of this study includes 173 students of SMAN in Tangerang Selatan that were in acceleration and regular program. Overexcitability measured by an adaptation version of the Overexcitability Questionnaire II (OEQ II). Data analysis used is independent sample t-test. The results showed that H0 was rejected (Sig. 0.001, p 0.05) which means that gifted students have a higher overexcitability score than regular students. However, the only significant ones were psychomotor (Sig. 0.041, p 0.05), intellectual (Sig. 0.009, p 0.05), and imaginational overexcitability (Sig. 0.000, p 0.05).
Protestas sociales en el Perú: consecuencias en la salud mental de la población
Authors: Valle Rubén , Contreras-Pizarro Carlos H. 
Published: July 2023

Sr. Editor,
Desde mediados de diciembre del 2022 hasta parte de febrero del 2023 se desarrollaron en el Perú protestas sociales de gran magnitud que expresaron el reclamo de un sector de la población (1). Así, se registraron incidentes de violencia entre protestantes y las fuerzas del orden, bloqueo de carreteras, toma de aeropuertos, entre otros (2). Estos incidentes produjeron la paralización de actividades económicas, sentimiento de inseguridad e incertidumbre social (1); y al 5 de febre-ro del 2023, 59 fallecidos y 1229 heridos (2). Además, millones de personas atestiguaron estos incidentes directa o indirectamente por medios de comunicación y redes sociales.
ОЦІНКА КОНКУРЕНТОСПРОМОЖНОСТІ ТУРИСТИЧНО-РЕКРЕАЦІЙНОЇ СФЕРИ РЕГІОНІВ УКРАЇНИ
Authors: КРАВЦІВ Василь , ЖУК Петро 
Published: July 2023

Оцінено конкурентоспроможність туристично-рекреаційної сфери регіонів України. На основі застосовуваної при підготовці Світовим економічним форумом звітів «Конкурентоспроможність у сфері подорожей і туризму» методології визначення індексів конкурентоспроможності країн у сфері подорожей і туризму (The Travel & Tourism Competitiveness Index) запропоновано методичні підходи до оцінювання конкурентоспроможності цієї сфери на рівні регіонів України. Визначено алгоритм, показники та індикатори оцінювання, наведено розрахункові формули для обчислення часткових та інтегральних індексів конкурентоспроможності туристично-рекреаційної сфери регіонів. Висвітлено результати оцінювання за чотирма групами обраних показників – сприятливість середовища (три підгрупи показників: економічне середовище, безпека, демографія і ринок праці з відповідними індикаторами); інфраструктурний розвиток (дві підгрупи: транспортна інфраструктура, інформаційна і банківська інфраструктури); природні та історико-культурні ресурси (дві підгрупи: природно-ресурсний потенціал, історико-культурні ресурси); рівень розвитку оцінюваної сфери (одна підгрупа: розвиток туристично-рекреаційної сфери). Наведено часткові та інтегральний індекси регіонів за конкурентоспроможністю туристично-рекреаційної сфери. Здійснено аналіз отриманих результатів оцінювання і виокремлено регіони з найвищим потенціалом конкурентоспроможності туризму й рекреації. До них віднесено ті, що мають високі природно-ресурсний і історико-культурний потенціали туристично-рекреаційної діяльності – Львівська, Одеська, Закарпатська, Івано-Франківська області, а також регіони з високими економічним і демографічним потенціалами, розвинутою інфраструктурою – Київ, Дніпропетровська, Запорізька, Харківська, Київська області.
Вказано на доцільність використання переважно оціночних показників та індикаторів, які мають об’єктивний вимір. Водночас окреслено проблеми, пов’язані з відсутністю туризму і рекреації у національному класифікаторі видів економічної діяльності й системі вітчизняної статистики. Наголошено на вразливості туристично-рекреаційної діяльності стосовно чинників безпеки під час війни.
A Social Care System Implemented in Pediatric Primary Care: A Cluster RCT
Authors: Garg Arvin , Brochier Annelise , Tripodis Yorghos , Messmer Emily , Drainoni Mari-Lynn 
Published: July 2023

OBJECTIVES
To assess the implementation and effectiveness of the augmented WE CARE social care system on low-income children’s health care utilization and child maltreatment outcomes.

METHODS
We conducted a type 1 hybrid effectiveness-implementation cluster randomized controlled trial at 6 community health centers. Full-term infants were followed from birth to age 3. The 3 experimental clinics implemented the augmented WE CARE system at well-child visits, consisting of a self-report screening instrument for 7 basic needs; an electronic health record-generated resource information referral system; and access to a peer patient navigator. Families at control community health centers received usual care; 1 control site was contaminated and removed from primary analysis. We analyzed results using generalized mixed-effects models.

RESULTS
Overall, 878 children were followed until age 3. Implementation of WE CARE was poor with only 28.9% of visits having a WE CARE screener documented. WE CARE families received significantly more resource referrals than control families (43.1% vs 1.9%, adjusted odds ratio 4.6; 95% confidence interval, 2.0–5.6); 20% were referred to the patient navigator. WE CARE children had significantly higher immunization adherence ratios. Although there were no statistically significant differences with well-child visits, WE CARE children had higher rates of emergency department visits than control children. By age 3, WE CARE children had significantly higher hospitalization rates (14.1% vs 10.4%, adjusted odds ratio 1.3, 95% confidence interval: 1.03–1.7). There were no statistically significant differences with maltreatment outcomes.

CONCLUSIONS
We found poor implementation and mixed benefits for the augmented WE CARE system on immunization, health care utilization, and maltreatment outcomes in early childhood.
PROSPECTS FOR THE USE OF WOVEN METAL MESHES AS PHASE SEPARATORS
Authors: Davydov S.A. , Davydova A.V. , Kryvenko A.A. , Chupryna A.A. 
Published: July 2023

The constant complication of the tasks that arise before spacecraft during their flight mission puts very high demands on the fuel supply system. First of all, during orbital flight, very often there is a need to restart the main engines, or a constant supply of fuel to the engines of the control system. It is necessary to deliver fuel from tanks to engine combustion chambers in conditions of practical weightlessness. To ensure the ingress of fuel components from the tank into the drain line without gas inclusions, a fuel continuity system is added to the fuel supply system.
Among the various systems for ensuring fuel continuity, the most widespread over the past fifty years have been mesh phase separators, the main working element of which is woven metal mesh.
The paper considers the basic properties of systems of this type, their main design parameters from the point of view of the possibility of their improvement and the possibility of use in future designs of spacecraft. Considerable attention is paid to the shortcomings inherent in systems of this type. Possible ways to eliminate the limitations of the use of mesh phase separators through the development of new engineering design techniques and the use of modern technologies to create analogues of woven metal meshes, which are devoid of their main drawbacks, are considered.
AUTOMATED PIPELINE INSPECTION USING UNMANNED AERIAL VEHICLES
Authors: Shadrenkin P. V. , Tokarev A. P. 
Published: July 2023

Monitoring the condition of pipelines and site facilities of the oil and gas trunk transportation system, as well as other facilities of the oil and gas complex, allows you to collect the necessary information quickly, getting into hard-to-reach places where land transport or a person cannot get to, and reduce the response time to emergency situations and eliminate their consequences.
The paper considers the existing designs of unmanned aerial vehicles used in systems for remote monitoring of technological facilities, analyzes their advantages and disadvantages while inspecting the linear part of the trunk pipeline. Two variants for automated platforms placing along the route for taking off and recharging unmanned aerial vehicles are proposed. The first variant allows more thorough inspection while flying around, the second one allows using fewer platforms and longer inspection area.
ECOANALYTICAL CONTROL OF SURFACE WATERS IN THE ZONE OF INFLUENCE OF THE YAMBURG OIL AND GAS CONDENSATE FIELD
Authors: Kuznetsova G. M. , Kudryavtseva I. Yu. , Ilikbaeva V. Yu. , Kuznetsov V. O. 
Published: July 2023

The article is devoted to the actual problem of surface water monitoring in the zone of influence of oil and gas producing enterprises.
Aims and Objectives – comprehensive pollution assessment of natural water bodies located in the zone of influence of wastewater injection landfills of the integrated gas treatment plants IGTP-1 and IGTP-2 of the Yamburg Oil and Gas Condensate Field using the water pollution index.
The pollution assessment of natural waters was carried out in accordance with State Standard 17.1.3.07-82 «Nature protection. Hydrosphere. Procedures for quality control of water in reservoirs and stream flows». The average regional values of the controlled components correspond to the «Handbook on the use of average regional values of controlled Component content at monitoring Sites when assessing the state and level of environmental pollution in the Yamalo-Nenets Autonomous Okrug».
It has been concluded that, on average, the water pollution index of the studied territory for the period since 2019 up to 2021 corresponds to the 2nd quality class («clean»), excluding from the calculation the concentration of iron – a typomorphic element of the natural waters of the North taiga zone.
evaluación de la biblioteca digital académica desde el enfoque teórico de la aceptación tecnológica
Authors: Medina Hernández Ana Isabel 
Published: July 2023

Este artículo presenta una investigación sobre la intención de los usuarios para aceptar la biblioteca digital académica en Puerto Rico. Se utiliza como modelo la teoría unificada de aceptación y uso de la tecnología (UTAUT) de Venkatesh et al. (2003). Esta teoría establece que la intención de uso está influenciada por cuatro factores: expectativa de funcionamiento, expectativa de esfuerzo, influencia social y condiciones facilitantes. La investigación se realizó en la Biblioteca Conrado F. Asenjo del Recinto de Ciencias Médicas (RCM) de la Universidad de Puerto Rico (UPR). La metodología aplicada al entorno bajo estudio fue la cuantitativa y el método de recolección de datos fue la encuesta. La población participante fueron estudiantes de las Escuelas de Enfermería, Farmacia, Medicina, Medicina Dental, Profesiones de la Salud y Salud Pública del RCM de la UPR. El estudio encontró que los constructos expectativa de funcionamiento, influencia social y condiciones facilitantes tienen un efecto directo, positivo y significativo sobre la intención de los usuarios de la biblioteca digital. Los resultados indican que el efecto de la expectativa de esfuerzo sobre la intención fue negativo y no significativo.
An Optimum 1D Velocity Model for the Garhwal–Kumaun Himalaya Using Monte Carlo Style Inversion
Authors: Kanaujia Jyotima , Ravi Kumar M. , Vijayaraghavan R. , Solomon Raju P. 
Published: July 2023

Abstract
A Monte Carlo based algorithm is developed to improve the 1D velocity inversion routines and minimize bias due to the choice of a starting model. Using this algorithm, a well-resolved six-layer minimum 1D velocity model, down to ∼24 km depth, is determined for the Garhwal–Kumaun Himalaya. A total of 4765 P- and 4724 S-phase travel times of local earthquakes recorded at 53 broadband seismic stations are used for this purpose. The travel time–distance curves from these carefully analyzed phase data of events are used to subsequently derive a prior 1D velocity model. Forward modeling of the travel time–distance curve yields an average Moho depth of ∼46 km and bulk crustal P- and S-wave velocity values of 7.60 and 4.47 km/s, respectively. To circumvent the subjectivity due to manual intervention in the inversion and automate the process, we propose a Monto Carlo style semirandom generation of initial trial velocity models, guided by the initial values derived from forward modeling. The estimated minimum 1D model reveals P- and S-wave velocities increasing from 5.17 to 6.85 km/s and 3.12 to 3.82 km/s, respectively, from the surface to a depth of 26 km. Subsequently, an optimum model is constructed for the region by incorporating the Moho layer in the minimum 1D model.
Estrategia Pedagógica Disruptiva para Fortalecer la Disciplina Militar y el Comportamiento Ético
Authors: QUINTEROPATIÑO VÍCTOR MIGUEL 
Published: July 2023

La investigación que origina este artículo, buscaba proponer una estrategia pedagógica novedosa para fortalecer el valor de la disciplina militar y el comportamiento ético de los estudiantes de la Escuela de Suboficiales de la Fuerza Aérea Colombiana. Esta fue de tipo cualitativo descriptivo con un enfoque interpretativo utilizando observación participante declarada, en ella, el autor asistió a clases del núcleo humanístico, el tiempo de observación en promedio fue de una hora y en escenarios diversos (aula y campo abierto), se hizo especial énfasis en observar las estrategias pedagógicas empleadas por los docentes y la respuesta de los estudiantes, se evidenció apatía en los que aprenden y debilidades metodológicas en los que enseñan, por lo que la validación de expertos de la propuesta resultó positiva por la vinculación permanente de herramientas virtuales de aprendizaje.
TRANSLATION ACCURACY OF ENGLISH COMPLEX SENTENCE INTO INDONESIAN IN THE NOVEL OF “JULIET” BY ANNE FORTIER
Authors: Azzahra Nur Shofa , Ruminda Ruminda 
Published: July 2023

Translation has contributed a huge effect to everyday life since its existence. The translation is a very complex language activity that requires the translator to have knowledge on language and grammar, at the same time culture, social, religion, and material. The purpose of this study is to assess the translation accuracy of English complex sentences into Indonesia in a novel entitled “Juliet” written by Anne Fortier using the theory of Nababan’s translation accuracy assessment. The novel is the most dominant literary work to read. Nowadays, there are a lot of novels have been translated into various languages. It contains various sentence structures, and the structure should be translated well. The complex sentence has a complex and challenging structure. The method used in this study is qualitative. 52 data are collected and ranged from 1 to 3, depending on their accuracies. The higher the score shows, the more accurate translation; and the lower the score, the less accurate translation. The result showed that the translations are accurate, with a score of 2,7.
Bentuk Afiksasi pada Teks Narasi Mahasiswa BIPA: Kajian terhadap Hasil Tulis Mahasiswa BIPA Asal Afghanistan Angkatan Tahun 2021 di Universitas Muhammadiyah Malang
Authors: Nazihatun Najiba  , Wurianto Arif Budi , Isnaini M. 
Published: July 2023

Penelitian ini bertujuan menjelaskan atau mendeskripsikan bentuk serta makna afiksasi yang digunakan pada teks narasi mahasiswa BIPA asal Afghanistan angkatan tahun 2021 di Universitas Muhammadiyah Malang. Penelitian ini menggunakan pendekatan kualitatif metode deskriptif. Sumber data dalam penelitian ini berupa primer dan sekunder. Data primer berasal dari hasil karangan dua mahasiswa BIPA asal Afghanistan yang sedang menempuh studi S2 di Universitas Muhammadiyah Malang melalui program KNB (Kemitraan Negara Berkembang) yang dibuktikan dengan data sekunder berupa observasi secara langsung yang dilakukan selama 6 bulan mulai 6 September 2021 sampai 8 Maret 2022. Hasil penelitian ini ditemukan kesalahan penggunaan afiksasi disebabkan oleh kesalahan proses morfofonemis, kesalahan penggunaan afiks, kesalahan penggunaan kata dasar, dan kesalahan yang disebabkan oleh interferensi interlingual yaitu kesalahan akibat pengaruh dari B1 atau bahasa ibu terhadap B2 atau bahasa target. Temuan dalam penelitian ini dapat digunakan sebagai bahan evaluasi dalam proses pembelajaran BIPA terutama dalam materi afiksasi.
Aplikasi Spotify: Solusi Baru dalam Pembelajaran Menulis Cerpen di SMA
Authors: Hasan Jihan Septiani , Lubis Fitriani 
Published: July 2023

Tujuan penelitian ini (1) mendeskripsikan kemampuan menulis teks cerpen siswa kelas XI SMA Negeri 6 Medan dengan menerapkan aplikasi Spotify sebagai media pembelajaran; (2) mendeskripsikan kemampuan menulis teks cerpen siswa kelas XI SMA Negeri 6 Medan tanpa menerapkan aplikasi Spotify sebagai media pembelajaran; (3) mendeskripsikan pengaruh penerapan aplikasi Spotify sebagai media pembelajaran terhadap kemampuan menulis teks cerpen siswa kelas XI SMA Negeri 6 Medan. Metode penelitian yang digunakan adalah metode eksperimen dengan posttest-only control design. Hasil penelitian menunjukkan: (1) mean kelas yang menerapkan aplikasi Spotify adalah 82,2 dengan standar deviasi 11,51347 (2) mean kelas tanpa menerapkan aplikasi Spotify adalah adalah 54,8 dengan standar deviasi 21,43725 (3) Hasil perhitungan uji hipotesis diperoleh thitung = 6,699 dan ttabel = 1,667. Simpulan Ha diterima, yaitu thitung > ttabel, artinya adanya pengaruh positif pada penerapan aplikasi Spotify sebagai media pembelajaran menulis teks cerpen siswa kelas XI SMA Negeri 6 Medan. Aplikasi Spotify dapat digunakan sebagai alternatif media pembelajaran terkhusus sastra, dikarenakan: (1) meningkatkan antusias siswa berargumen dalam menentukan unsur-unsur pembangun teks cerpen yang didengar dari podcast, (2) menjadi referensi bagi siswa mengenai tema-tema cerpen dan majas, yang terdapat dalam Spotify (3) dapat melatih kemampuan menyimak siswa, karena proses kerja media Spotify belajar sambil mendengarkan.
Representation and Commodification of Female Body in the Indonesian Post Reform Horror Movies
Authors: Larasati Verena Vinandia , Wahid Abdul 
Published: July 2023

This study examines the representation and commodification practices of female bodies in the Indonesian horror films produced in the Post Reform Era. Three horror movies, i.e. Terowongan Casablanca (2007), Tali Pocong Perawan (2008), and Air Terjun Pengantin (2009), have been analyzed with qualitative textual analysis. This study finds that the female body is commodified in the movies through the costumes that show clearly their sexy bodies, the actions and gestures that demonstrate their seductive lust, and the setting of scenes that emphasize their sexual desires. These representations are closely related with the producers backgrounds and track records in the way that they are used to producing horror movies that mostly using sexy woman as lead actress. Keywords: representation, commodification, Indonesian horror movies, female body.
Battling Underaged Online Video Gamers: Probing the Negative Effects of Online Video Gaming Addictions on Young Adolescents
Authors: Demuyakor John 
Published: July 2023

Many countries, including China, have declared online video gaming addictions among children and young adolescents as a public health emergency. With these growing concerns about the number of times children and young adolescents of school-going age spend time playing online video games, this study seeks to examine the adverse effects of online video gaming among young adolescents aged 13-17. This article drew on the theory of online gaming addiction and employed a qualitative research design through in-depth interviews. This study has collected data from 40 respondents in five public junior high schools in the Chaoyang District of Beijing, China. The data analysis was done through consolidated thematic analysis. This study finds that online video gaming platforms have significantly resulted in excessive addictions and negatively affected students' educational achievements, social relations, and physical and mental health. Keywords: online video games; addictions; young adolescents; China’s public junior high schools.