bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors affecting community-based health insurance utilization among households in Degadamot District, Ethiopia: Community-based cross sectional study
Authors: Belayneh Melesse 
Published: June 2023

Abstract
Background: Community-based health insurance is provided in several countries as part of the overall health funding approach, Including Ethiopia. Ethiopia has been utilizing the Basic healthcare model and has endured a number of fundamental issues, such as insufficient service coverage, unequal access, and high out-of-pocket expenses. However, there are few studies showed that low CBHI utilization. However, enrollment is a progressive activity, and there is updated evidence about factors of utilization.
Objective: This study was focused on the factors affecting community-based health insurance utilization among households in Degadamot District, Ethiopia, in 2022.
Methods: A community-based cross-sectional study was employed among 736 households from August 15 to October 15, 2022. Participants were screened by using a two-stage sampling technique. Data were collected using an interviewer-administered pre-tested questionnaire and entered into EPI-Info 7 and transported to SPSS version 26. Multi-variable logistic regression was performed to further analysis. A p-value less than 0.05 with a 95% confidence interval accounted significantly between dependent and independent variables.
Result: Among the total of 736 respondents, 66.7% [63.2%–70.1%] of them reported being members of the CBHI scheme. The mean age (±SD) of the study participants was 44.9 (±16.5) years. The multivariate logistic regression analysis showed that participants who were aged in years of 35-54 years(AOR=2.89; 95% CI: 1.78, 4.69), 55-74 years(AOR=3.84; 95% CI: 2.18, 6.75), >= 75 years(AOR=2.25; 95% CI: 1.04, 4.89), family size of households who had 5 and above members(AOR=2.06; 95% CI: 1.43-2.95), primary education(AOR=2.10; 1.43, 2.95), secondary and above education(AOR=2.50; 95% CI: 1.88, 4.99), had own land (AOR: 1.62; 95% CI: 1.26, 3.54), had own domestic animals (AOR=2.11; 95% CI: 1.26, 3.54), enrolled in Safety net program (AOR=2.80; 95% CI: 1.52-5.15) and had good knowledge about CBHI(AOR=3.16; 95% CI: 2.08, 4.45) factors were significantly associated with CBHI utilization.
Conclusion: community-based health insurance utilization was affected by factors with age, family size, residence, educational status, owning land and domestic animals, being enrolled in the Safety Net program, and having good knowledge about CBHI were associated with CBHI utilization. As a result, a strong monitoring and evaluation system, strategies designed to increase awareness levels about the CBHI scheme's benefits, special considerations for aged people, and collaboration with social security sectors.
Research on Thermal Aging Properties of Modified E-51 Epoxy Resin for Cryogenic Application
Authors: Shu Shi , Zhang Xudong , Yang Jiaquan , Yang Yang , Li Mengyang , Hu Nannan 
Published: June 2023

Abstract
E-51 epoxy resin with medium viscosity can be used to. fabricate mechanical or insulating structural components. However, because of its brittleness, the unmodified E-51 epoxy resin system can’t absorb significant internal stress at cryogenic temperature. As a result, a modified E-51 epoxy resin system for cryogenic application was developed to investigate the thermal aging properties, which aims at understanding the impact of heating temperature and heating time on the evolution of micro-structure, thermo stability, and mechanical properties. Testing results show that the modified E-51 epoxy resin system has a stable micro-structure after undergoing 50 thermal cycling and 50 thermal cycling while heating at 105℃ with a duration of 120 hours. However, the mechanical tensile strength of the modified E-51 epoxy resin system undergoes a decline of approximately 13.63% when the heating duration increases to 240 hours. Moreover, heating the modified E-51 epoxy resin system for 480 hours can lead to significant changes in the micro-structure, which ultimately affects the mechanical tensile testing results. Therefore, to achieve high performance, achieving micro homogeneity and modification of the E-51 epoxy resin system are critical.
Biliary Neuroendocrine Neoplasms: A Clinicopathological and Prognostic Analysis of 36 Clinical Cases
Authors: Zhao Zhihao , Wu Qingyuan , Jiang Chao , Wang Meng 
Published: June 2023

Abstract

Background
Biliary neuroendocrine neoplasms are rare diseases characterized by low morbidity, difficult diagnosis, and poor prognosis. In this study, we aimed to provide a better understanding of this disease by analyzing the clinicopathological features, treatment, and factors associated with prognosis of 36 cases of neuroendocrine neoplasms arising from the gallbladder, bile ducts, and ampulla of Vater.
Results
The early stages of the disease often present with atypical symptoms, leading to a delayed diagnosis in most cases, abdominal discomfort was the primary manifestation at diagnosis. Neuroendocrine carcinoma was the most common pathological stage observed, with small-cell neuroendocrine carcinomas being the predominant subtype. Tumor recurrence occured mostly in the liver. The median follow-up time was 39 months, and the median survival time was 30 months. The 1-, 2-, and 3-year survival rates were 63.9%, 51.0%, and 35.7%, respectively. No significant effects of adjunctive therapy on prognosis were found. Pathological grade and access to R0 margin were found to be significantly associated with overall survival.
Conclusions
Biliary neuroendocrine neoplasms are challenging to diagnose at an early stage due to the absence of typical symptoms. Liver metastasis is relatively common in desease recurrence and is indicative of a poor prognosis., and poor histological grading and the inability to achieve R0 margin significantly shorten the survival period.
Swyer-James-Macleod Syndrome In A Geriatric Patient: A Case Report
Authors: Panchal Ishita , SHAH ABHI , Bhowmik Subham , Vohra Rimsha Rahim , Bloom Kim , Lloyd Kenneth Scott 
Published: June 2023

Abstract
Introduction:
Hyper-lucent lung syndrome or Swyer-James-Macleod syndrome is a rare, often an incidental finding, primarily showing unilateral hyper-lucency as a consequence of bronchiolitis obliterans. Often diagnosed in early childhood; though in some cases it may only be discovered in adulthood or on account of recurrent chest infections.
Case Presentation:
A patient presented to our outpatient center with complaints of shortness of breath with mild to moderate exertional dyspnea & exacerbations of symptoms classically associated with chronic obstructive pulmonary disease. Complaints have persisted for several years with waxing & waning intensity. There is a history of migraine, atrial fibrillation, hypothyroidism, and colon & breast cancer without recurrence.
Computed tomography of the chest with intravenous contrast showed asymmetric emphysematous changes with marked hyperinflation & attenuated vasculatures confined to the middle lobe of the right lung.
The patient was started on a combination of inhaled long-acting beta-agonists, corticosteroids & long-acting muscarinic antagonists and is almost asymptomatic.
Conclusion:
Geriatric patients are at increased risk of various age-related diseases, respiratory disorders being among them. Knowledge of this rare condition allows for its appropriate management as it often coexists with bronchiectasis & results in frequent respiratory infections, which may be preventable.
High figure of merit refractive index sensor derived from the axial length ratio of elliptically polarized light of chiral plasmonic structure arrays
Authors: Zhu Xupeng , Shi Huimin , Zhang Shi , Zheng Mengjie , Dai Peng , Huang Ruomeng , Liao Jun , Xue Shuwen , Zhang Jun 
Published: June 2023

Abstract
The refractive index sensor based on the Fano resonance effect (that is, Fano sensor) is one promising branch of plasmonic sensing applications owing to its narrow spectral line shape. Further improvement in the sensitivity and figure of merit (FOM) is the main issue in this field. In contrast to the Fano sensor, herein, we report a novel ultra-sensitive refractive index sensor based on the axial length ratio of transmitted elliptically polarized light of chiral plasmonic structure arrays (that is, ratio sensor). Compared with the optimized Fano sensor in the same asymmetric chiral plasmonic structure arrays, the proposed ratio sensor shows a better sensitivity performance of 556.9 nm/RIU, that is 1.31 times higher than that of the optimized Fano sensor. Specifically, the quality factor of the spectral line shape and FOM of the proposed ratio sensor reach 121.6 and 60, respectively, that are 2.14 and 2.92 times higher than those of the optimized Fano sensor, respectively. Our study proposes a potential path to achieve high-quality ultra-sensitive refractive index sensing.
Genotype-phenotype analysis in patients with PAX2 mutations: beyond renal coloboma syndrome
Authors: Kim Ji Hyun , Ahn Yo Han , Jang Yeonji , Park Eujin , Lee Hajeong , Kim Seong Heon , Song Ji Yeon , Han Kyoung Hee , Jung Jiwon , Lee Joo Hoon , Kang Hee Gyung , Jung Jae Ho , Cheong Hae Il 
Published: June 2023

Abstract
PAX2-related disorders encompass renal coloboma syndrome (RCS) and hereditary focal segmental glomerulosclerosis (FSGS)type 7. In this multicenter study on patients with PAX2 mutations, we explored genotype-phenotype correlations regarding kidney and ocular involvement and long-term clinical outcomes. Among 27 patients with PAX2 mutations detected from 2004–2022, 19 had RCS, 4 had FSGS, and 4 had isolated congenital anomalies of the kidneys and urinary tract (CAKUT). Based on genotypes, patients were classified into truncating (n=22) and missense (n=5) mutation groups. Truncating mutations were associated with RCS in 81.8% of cases, while missense mutations were linked to FSGS (n=2) and isolated CAKUT (n=2) in 80.0% of cases (P=0.034). Fourteen patients developed kidney failure at a median age of 14.5 years, with no difference in kidney survival between the truncating and missense mutation groups. However, mutations in the paired domain of PAX2 resulted in kidney failure more rapidly than mutations in other sites (P=0.025). Regarding ocular manifestations, the truncating mutation group exhibited more common, earlier onset and severe involvement compared to the missense mutation group. Our findings support genotype-phenotype correlations in ophthalmology field and emphasize the impact of the paired domain on kidney outcomes in patients with PAX2mutations.
Development and validation of a rating scale for barriers and facilitators of nurses' participation intention on “Internet + nursing service”
Authors: Tian Fei , Peng Zhekang , Mi Yuanyuan , Xi Zuyang , Zhang Zhaohui , Gui Shengmin , Liu Min , Zhang Ting , Qu Xingguang , Liu Jinglan 
Published: June 2023

Abstract

Background: With the increasing pace of China's aging population, the growing demand for public health services and the shortage of nursing human resources have become more prominent. The “Internet+ Nursing Services” have received more attention. Exploring the obstacles and promoting factors of nurses' willingness to participate in “Internet+ Nursing Services” and utilizing internet technology to increase the supply of nursing services has become a key issue.
Objective: This study aimed to develop a scale for assessing the obstacles and promoting factors of nurses' willingness to participate in “Internet+ Nursing Services”, and to test the validity and reliability of the scale.
Methods: A preliminary scale was developed through literature review, theoretical research, semi-structured qualitative interviews, and two rounds of Delphi expert inquiry. A convenience sampling method was used for the questionnaire survey. Likert 5-point scoring was used to assign importance to the items. The survey data of 659 clinical nurses from February to March 2023 were used for item analysis, exploratory factor analysis, and reliability and validity tests of the pre-test scale. The survey data of 538 clinical nurses in April 2023 were used for confirmatory factor analysis of the formal scale.
Results: The final scale consisted of 25 items and 4 dimensions (performance expectation, perceived risk, professional knowledge training needs, and non-professional knowledge training needs). The scale showed good structural validity and content validity: the Cronbach's α coefficient of the scale was 0.955, the split-half reliability was 0.778, the test-retest reliability was 0.944, the KMO value was 0.960, and the cumulative variance contribution rate of the 4 common factors was 83.147%. The content validity index of the scale (S-CVI) was 0.914. The confirmatory factor analysis model fit indices were good: χ2/df=4.234, RMSEA=0.078, NFI=0.940, IFI=0.953, TLI=0.947, and CFI=0.953.
Conclusion: The scale for assessing the obstacles and promoting factors of nurses' willingness to participate in “Internet+ Nursing Services” has good reliability and validity, and provides a reference for evaluating nurses' willingness to participate in “Internet+ Nursing Services”.
Spatial Quasi-Bound States of Dirac Electrons in Graphene Monolayer
Authors: Miniya Mohammed , Oubram Outmane , Hachimi Abdel Ghafour El , Gaggero-Sager Luis Manuel 
Published: June 2023

Abstract
Our study investigated the emergence of spatial Quasi-Bound States (QBSs) in graphene mono- layers induced by rectangular potential barriers. By solving the time-independent Dirac equation and using the transfer matrix formalism, we calculated the resonance energies and identify the QBSs based on probability density functions (PDF). We analyzed two types of structures: single and dou- ble barriers, and we find that the QBSs are located within the barrier region, at energies higher than the single barrier. Additionally, we observe QBSs in the double barrier and their position depends on the distance and width of the well between the two barriers. The width and height of the barrier significantly impact the QBSs while the well width influences the resonance energy levels of the QBSs in the double barrier. Interestingly, the QBSs can be manipulated in the graphene system, offering potential for optoelectronic devices. Finally, our results demonstrated that the spatial localization of these states is counter-intuitive and holds great promise for future research in optolectronic devices.
Cytokines and metabolites are the main descriptors of severe asthma in children when performing multi-omics analysis of bronchoaleveolar lavages
Authors: Briard Mélanie , Guillon Blanche , Venot Eric , Grauso Marta , Hennequet-Antier Christelle , Bruneau Aurélia , Fenaille François , Castelli Florence , Thomas Muriel , Lezmi Guillaume , Leite-de-Moraes Maria , Saint-Criq Vinciane , Adel-Patient Karine 
Published: June 2023

Abstract
Background. Severe asthma (SA) is a heterogeneous condition with multiple phenotypes. There is still an unmet need to characterize and understand underlying mechanisms taking place in the lungs in order to propose the most suitable therapeutic strategies for SA. For this purpose, we aimed to identify a local signature of severe asthma by conducting comprehensive multi-omics analysis of bronchoalveolar lavages fluids (BALs) from children with SA versus non-asthmatic (NA) controls.
Method. BALs were collected from twenty children with SA and from ten age-matched NA. We previously analyzed soluble and cellular immune components in those samples, and now propose to perform comprehensive analysis of their microbiota and their metabolome. Briefly, DNA from BALs was extracted and 16S rRNA gene (V3-V4 region) was amplified by PCR and sequenced. In parallel, untargeted metabolomics was performed using liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) following an established workflow for sample preparation, data acquisition and treatment. Each microbiome and metabolome dataset was first analysed independently by unsupervised multivariate analyses (Principal component analyses, PCA). Differences between groups for microbiota diversity indices, the relative distribution of each phyla and genera were then analysed. Metabolite set enrichment analysis (MSEA) and univariate supervised analysis were also performed. To identify a local signature of severe asthma, microbiota and metabolome data were further integrated, together with immune and with clinical data, using unsupervised Multi-Omics Factor Analysis (MOFA).
Results. Microbiota diversity was higher in children with SA versus NA, with higher relative abundances of Streptococcus, Corynebacterium, Tropheryma whipplei, Dolosigranulum pigrum and Moraxella nonliquefaciens. We identified 88 metabolites in BALs, but unsupervised PCA of corresponding data did not differentiate children with SA from NA. However, MSEA evidenced that biotin and carnitine synthesis, lysine degradation, methionine metabolism and spermidine and spermine biosynthesis pathways were significantly enriched in children with SA. Finally, multiblocks data integration identified a signature of SA, mainly described by metabolites and cytokines.
Conclusion. By integrating metabolome, microbiome and cytokines data obtained on BALs from children with severe asthma versus NA, our study uniquely described a local signature of SA.
Detection of Yield and Physiological Responses to Water Stress using Leaf Turgor Pressure and Thermal Images in Pepper
Authors: Camoglu Gokhan , Demirel Kursad , Kahriman Fatih , Akcal Arda , Nar Hakan 
Published: June 2023

Abstract
Today, the use of sensors and imaging techniques to obtain information about plants and soil in smart irrigation systems is rapidly becoming widespread. This study aimed to investigate the usability of leaf turgor pressure and thermal images to detect water stress and the irrigation time of pepper and to determine their relationship with physiological traits (leaf water potential, stomatal conductivity, superoxide dismutase, and catalase activity). For this purpose, the pepper (Capsicum annuum L. cv. "California Wonder") experiment was carried out in Canakkale, Turkey in 2017 and 2018. A total of four treatments were applied in the experiment, control (100%) and three different water stress levels (75%, 50%, and 25%). Leaf turgor pressure (Pp), thermal images and physiological measurements were carried out during the growing season. Soil moisture and leaf turgor pressure (Pp) were monitored in real time by remote. As a result of the study, the average evapotranspiration (ETc) was 697 mm, and the yield value was 83.7 t ha− 1 under non-stress conditions. Depending on the decrease in ETc, yield values also decreased significantly. The physiological traits of pepper were also adversely affected by water stress. Leaf water potential and stomatal conductivity values were statistically different in all irrigation treatments. The change in the activity of catalase (CAT) due to water stress was greater than that of superoxide dismutase (SOD). In this case, it can be said that other physiological traits are more successful than SOD in distinguishing water stress. According to the regression models, significant relationships were determined between both the indices calculated from the thermal images and Pp, yield and physiological traits. The predictive ability of Pp values has been strengthened with the addition of meteorological properties to the model in general. The highest correlation (R2 = 0.63) was between Pp + meteorological properties and the catalase activity. All the regression models between CWSI and IGp calculated from thermal images were statistically significant. The highest R2 values were obtained in August. In this month, the highest correlations were between CWSI and leaf water potential and stomatal conductivity (R2 = 0.91), IGp and stomatal conductivity (R2 = 0.80). The predictive power of CWSIp was higher than IGp. The experiment illustrated that Pp and temperature data, which are plant-based monitoring methods, have the potential to detect water stress in peppers.
Mutation in yl-HOG1 represses the filament-to-yeast transition in the dimorphic yeast Yarrowia lipolytica
Authors: Rzechonek Dorota A. , Szczepańczyk Mateusz , Mirończuk Aleksandra M. 
Published: June 2023

Abstract
Background
Yarrowia lipolytica is a dimorphic fungus, which switches from yeast to yeast-to-filament form in response to environmental conditions. For industrial purposes it is important to lock cells in the yeast or filamentous form depending on the fermentation process. yl-Hog1 kinase is a key component of the HOG signaling pathway, responsible for activating the osmotic stress response. Additionally, deletion of yl-Hog1 leads to increased filamentation in Yarrowia lipolytica, but causes significant sensitivity to osmotic stress induced by a high concentration of a carbon source.
Results
In this study, we tested the effect of point mutations on the function of yl-Hog1 protein kinase. The targets of modification were the phosphorylation sites (T171A-Y173A) and the active center (K49R). Introduction of the variant HOG1-49 into the hog1∆ strain partially improved growth under osmotic stress, but did not recover the yeast-like shape of the cells. The HOG1-171/173 variant was completely inactive, and its introduction further weakened the hog1∆ strains. To verify a genetic modification in filament form, we developed a new system based on green fluorescent protein (GFP) for easier screening of proper mutants.
Conclusions
These results provide new insights into the functions of yl-Hog1 protein in dimorphic transition and constitute a good starting point for further genetic modification of Y. lipolytica in filament form.
Emotional contagion in the human/dog dyad - physiological and cognitive consequences, and implications for pain management: A scoping review
Authors: Walt Ansi , Parker Romy 
Published: June 2023

Abstract
Objective
The objective of this scoping review is to explore the implications of human-dog dyadic interactions on canine chronic pain, by investigating the mediating role of human emotion on the affective and behavioural states of dogs typically associated with canine pain.
Introduction:
Canine chronic osteoarthritis pain causes significant burden of disease in pet dog populations. It is understood that chronic pain is complex and multidimensional, with poor correlation between disease severity and functional disability. Interactions with their human caregivers have measurable effects of affective and physiological states in dogs. A better understanding of how these interactions may affect functional disability in dogs with osteoarthritis pain will inform patient management approaches.
Inclusion criteria:
This review included studies evaluating behavioural, physiological, affective or cognitive changes in dogs, within a human-dog dyad, in response to human caregiver behaviour, personality or emotion.
Methods
The databases searched included PUBMED, SCOPUS, CINAHL, SOCINDEX, PSYCHARTICLES AND PSYCHINFO, and articles were screened by two independent reviewers for assessment against the inclusion criteria for the review.
Results
55 Full text articles were included in the results.
Conclusions
The data support the hypothesis that human affective states influence canine affect, physiology, cognition and behavioural adaptation.