bluuebunny/crossref_metadata_2025_split huggingface dataset:
KLF5 Promotes Tumor Progression and Parp Inhibitor Resistance in Ovarian Cancer
Authors: Wu Yong , Chen Siyu , Shao Yang , Su Ying , Li Qin , Wu Jiangchun , Zhu Jun , Wen Hao , Huang Yan , Zheng Zhong , Chen Xiaojun , Ju Xingzhu , Huang Shenglin , Wu Xiaohua , Hu Zhixiang 
Published: September 2023

AbstractOne major characteristic of tumor cells is the aberrant activation of epigenetic regulatory elements, which remodel the tumor transcriptome and ultimately promote cancer progression and drug resistance. However, the oncogenic functions and mechanisms of ovarian cancer (OC) remain elusive. Here, super‐enhancer (SE) regulatory elements that are aberrantly activated in OC are identified and it is found that SEs drive the relative specific expression of the transcription factor KLF5 in OC patients and poly(ADP‐ribose) polymerase inhibitor (PARPi)‐resistant patients. KLF5 expression is associated with poor outcomes in OC patients and can drive tumor progression in vitro and in vivo. Mechanistically, KLF5 forms a transcriptional complex with EHF and ELF3 and binds to the promoter region of RAD51 to enhance its transcription, strengthening the homologous recombination repair (HRR) pathway. Notably, the combination of suberoylanilide hydroxamic acid (SAHA) and olaparib significantly inhibits tumor growth and metastasis of PARPi‐resistant OC cells with high KLF5. In conclusion, it is discovered that SEs‐driven KLF5 is a key regulatory factor in OC progression and PARPi resistance; and potential therapeutic strategies for OC patients with PARPi resistance and high KLF5 are identified.
Multiporphyrinic architectures: Advances in structural design for photodynamic therapy
Authors: Gao Yuwei , Li Yan , Xu Zhengwei , Yu Shuangjiang , Liu Junqiu , Sun Hongcheng 
Published: September 2023

AbstractRationally designed multiporphyrinic architectures for boosting photodynamic therapy (PDT) have attracted significant attentions recently years due to their great potential for light‐mediated generation of reactive oxygen species. However, there is still a gap between the structure design and their PDT performance for biomedical applications. This tutorial review provides a historical overview on (i) the basic concept of PDT for deeply understanding the porphyrin‐mediated PDT reactions, (ii) developing strategies for constructing porphyrinic architectures, like nanorings, boxes, metal‐organic frameworks (MOFs), covalent‐organic frameworks (COFs), vesicles, etc., where we classified into the following three categories: multiporphyrin arrays, porphyrinic frameworks, and others porphyrin assemblies, (iii) the various application scenarios for clinical cancer therapy and antibacterial infection. Also, the existing challenges and future perspectives on the innovation of porphyrinic architectures for clinical PDT applications are mentioned in the end section. Moreover, the porphyrinic nanomaterials with atomically precise architectures provide an ideal platform for investigating the relationship between structures and PDT outputs, design of personalized “all‐in‐one” theranostic agents, and the popularization and application in wider biomedical fields.
Secular trends and urban–rural disparities in height of Chinese adolescents aged 18 years from 1985 to 2019
Authors: Li Chengyue , Maimaiti Sigandan , Zhou Zhidong , Zang Liuhong 
Published: September 2023

AbstractObjectivesTo examine the secular trends and urban–rural disparities in height of Chinese adolescents aged 18 years from 1985 to 2019.MethodsData were extracted from the Chinese National Surveys on Students' Constitution and Health from 1985 to 2019, and the heights of a total of 76 554 boys and 75 908 girls aged 18 years were measured. The Mann–Kendall trend test was used to analyze the secular trends in height. Changes in different periods and urban–rural disparities were tested by z‐tests and calculating the ratios of the coefficient of variation (CV) of height.ResultsThe height of Chinese boys and girls aged 18 years increased from 168.21 and 157.10 cm in 1985 to 172.15 cm and 160.11 cm in 2019, respectively, with a larger increase in rural areas. The secular trends in height were the largest for boys from 1995 to 2005 and for girls from 2014 to 2019, and the same results were observed in urban and rural areas. The urban–rural disparities for boys and girls decreased by 1.79 and 0.91 cm, respectively, with significant decreases for boys in all regions and for girls in the eastern region. The overall CVs of height increased by 0.13% and 0.25% for boys and girls, respectively, with the largest increase among rural girls.ConclusionsThe height of Chinese adolescents aged 18 years continued to increase between 1985 and 2019. The urban–rural disparities narrowed, and inequalities within rural areas for girls increased.
Eutectic‐Based Polymer Electrolyte with the Enhanced Lithium Salt Dissociation for High‐Performance Lithium Metal Batteries
Authors: Zhang Dechao , Liu Yuxuan , Sun Zhaoyu , Liu Zhengbo , Xu Xijun , Xi Lei , Ji Shaomin , Zhu Min , Liu Jun 
Published: September 2023

AbstractThe deployment of lithium metal anode in solid‐state batteries with polymer electrolytes has been recognized as a promising approach to achieving high‐energy‐density technologies. However, the practical application of the polymer electrolytes is currently constrained by various challenges, including low ionic conductivity, inadequate electrochemical window, and poor interface stability. To address these issues, a novel eutectic‐based polymer electrolyte consisting of succinonitrile (SN) and poly (ethylene glycol) methyl ether acrylate (PEGMEA) is developed. The research results demonstrate that the interactions between SN and PEGMEA promote the dissociation of the lithium difluoro(oxalato) borate (LiDFOB) salt and increase the concentration of free Li+. The well‐designed eutectic‐based PAN1.2‐SPE (PEGMEA: SN=1: 1.2 mass ratio) exhibits high ionic conductivity of 1.30 mS cm−1 at 30 °C and superior interface stability with Li anode. The Li/Li symmetric cell based on PAN1.2‐SPE enables long‐term plating/stripping at 0.3 and 0.5 mA cm−2, and the Li/LiFePO4 cell achieves superior long‐term cycling stability (capacity retention of 80.3 % after 1500 cycles). Moreover, Li/LiFePO4 and Li/LiNi0.6Co0.2Mn0.2O2 pouch cells employing PAN1.2‐SPE demonstrate excellent cycling and safety characteristics. This study presents a new pathway for designing high‐performance polymer electrolytes and promotes the practical application of high‐stable lithium metal batteries.
Mixed‐Valence CuI/CuIII Metal–Organic Frameworks with Non‐innocent Ligand for Multielectron Transfer
Authors: Fu Shang‐Yuan , Chang Cheng‐Han , Ivanov Alexander S. , Popovs Ilja , Chen Jeng‐Lung , Liao Yen‐Fa , Liu Hsin‐Kuan , Chirra Suman , Chiang Yun‐Wei , Lee Jui‐Chin , Liu Wei‐Ling , Kaveevivitchai Watchareeya , Chen Teng‐Hao 
Published: September 2023

AbstractWe report two novel three‐dimensional copper‐benzoquinoid metal–organic frameworks (MOFs), [Cu4L3]n and [Cu4L3 ⋅ Cu(iq)3]n (LH4=1,4‐dicyano‐2,3,5,6‐tetrahydroxybenzene, iq=isoquinoline). Spectroscopic techniques and computational studies reveal the unprecedented mixed valency in MOFs, formal Cu(I)/Cu(III). This is the first time that formally Cu(III) species are witnessed in metal–organic extended solids. The coordination between the mixed‐valence metal and redox‐non‐innocent ligand L, which promotes through‐bond charge transfer between Cu metal sites, allows better metal‐ligand orbital overlap of the d‐π conjugation, leading to strong long‐range delocalization and semiconducting behavior. Our findings highlight the significance of the unique mixed valency between formal Cu(I) and highly‐covalent Cu(III), non‐innocent ligand, and pore environments of these bench stable Cu(III)‐containing frameworks on multielectron transfer and electrochemical properties.
Synthesis and Prospects of Holey Two‐dimensional Platinum‐group Metals in Electrocatalysis
Authors: Dutta Soumen , Gu Byeong Su , Lee In Su 
Published: September 2023

AbstractAdvanced electrocatalysts can enable the widespread implementation of clean energy technologies. This paper reviews an emerging class of electrocatalytic materials comprising holey two‐dimensional free‐standing Pt‐group metal (h‐2D‐PGM) nanosheets, which are categorically challenging to synthesize but inherently rich in all the qualities necessary to counter the kinetic and thermodynamic challenges of an electrochemical conversion process with high catalytic efficiency and stability. Although the 2D anisotropic growth of typical nonlayered metal crystals has succeeded and partly improved their atom‐utilization efficiency, regularly distributed in‐planar porosity can further optimize three critical factors that govern efficient electrocatalysis process: mass diffusion, electron transfer, and surface reactivity. However, producing such advanced morphological features within h‐2D‐PGMs is difficult unless they are specially engineered using approaches such as templating or kinetic ramification during 2D growth or controlled etching of preformed 2D‐PGM solids. Therefore, this review highlighting the successful fabrication of various porous PGM nanosheets and their electrocatalytic benefits involving smart nanoscale features could inspire next‐generation scientific and technological innovations toward securing a sustainable energy future.
Controlling Metal‐Oxide Reducibility for Efficient C−H Bond Activation in Hydrocarbons
Authors: Yang Guo‐Qing , Niu Yiming , Kondratenko Vita A. , Yi Xianfeng , Liu Chang , Zhang Bingsen , Kondratenko Evgenii V. , Liu Zhong‐Wen 
Published: September 2023

AbstractKnowing the structure of catalytically active species/phases and providing methods for their purposeful generation are two prerequisites for the design of catalysts with desired performance. Herein, we introduce a simple method for precise preparation of supported/bulk catalysts. It utilizes the ability of metal oxides to dissolve and to simultaneously precipitate during their treatment in an aqueous ammonia solution. Applying this method for a conventional VOx−Al2O3catalyst, the concentration of coordinatively unsaturated Al sites was tuned simply by changing the pH value of the solution. These sites affect the strength of V−O−Al bonds of isolated VOxspecies and thus the reducibility of the latter. This method is also applicable for controlling the reducibility of bulk catalysts as demonstrated for a CeO2−ZrO2−Al2O3system. The application potential of the developed catalysts was confirmed in the oxidative dehydrogenation of ethylbenzene to styrene with CO2and in the non‐oxidative propane dehydrogenation to propene. Our approach is extendable to the preparation of any metal oxide catalysts dissolvable in an ammonia solution.
On‐Surface Synthesis and Real‐Space Visualization of Aromatic P3N3
Authors: Zhong Qigang , Mardyukov Artur , Solel Ephrath , Ebeling Daniel , Schirmeisen André , Schreiner Peter R. 
Published: September 2023

AbstractOn‐surface synthesis is at the verge of emerging as the method of choice for the generation and visualization of unstable or unconventional molecules, which could not be obtained via traditional synthetic methods. A case in point is the on‐surface synthesis of the structurally elusive cyclotriphosphazene (P3N3), an inorganic aromatic analogue of benzene. Here, we report the preparation of this fleetingly existing species on Cu(111) and Au(111) surfaces at 5.2 K through molecular manipulation with unprecedented precision, i.e., voltage pulse‐induced sextuple dechlorination of an ultra‐small (about 6 Å) hexachlorophosphazene P3N3Cl6 precursor by the tip of a scanning probe microscope. Real‐space atomic‐level imaging of cyclotriphosphazene reveals its planar D3h‐symmetric ring structure. Furthermore, this demasking strategy has been expanded to generate cyclotriphosphazene from a hexaazide precursor P3N21 via a different stimulation method (photolysis) for complementary measurements by matrix isolation infrared and ultraviolet spectroscopy.
Non‐Covalent Interactions between Polyvinyl Chloride and Conjugated Polymers Enable Excellent Mechanical Properties and High Stability in Organic Solar Cells
Authors: Guan Chong , Xiao Chengyi , Liu Xin , Hu Zhijie , Wang Ruoyao , Wang Chao , Xie Chengcheng , Cai Ziqi , Li Weiwei 
Published: September 2023

AbstractThe incorporation of insulating polymers into conjugated polymers has been widely explored as a strategy to improve mechanical properties of flexible organic electronics. However, phase separation due to the immiscibility of these polymers has limited their effectiveness. In this study, we report the discovery of multiple non‐covalent interactions that enhances the miscibility between insulating and conjugated polymers, resulting in improved mechanical properties. Specifically, we have added polyvinyl chloride (PVC) into the conjugated polymer PM6 and observed a significant increase in solution viscosity, indicative of favorable miscibility between these two polymers. This phenomenon has been rarely observed in other insulating/conjugated polymer composites. Thin films of PM6/PVC exhibit a much‐improved crack‐onset strain of 19.35 %, compared to 10.12 % for pristine PM6 films. Analysis reveal that a “cyclohexyl‐like” structure formed through dipole‐dipole interactions and hydrogen bonding between PVC and PM6 acted as a cross‐linking site in the thin films, leading to improved mechanical properties. Moreover, PM6/PVC blend films have demonstrated excellent thermal and bending stability when applied as an electron donor in organic solar cells. These findings provide new insights into non‐covalent interactions that can be utilized to enhance the properties of conjugated polymers and may have potential applications in flexible organic electronics.
Receding horizon control for continuous‐time mean‐field systems
Authors: Gao Rong , Liu Junzhe , Zhang Fang , Xu Juanjuan , Wang Hongxia 
Published: September 2023

AbstractIn this paper, we study the receding horizon control (RHC) stabilization of continuous‐time mean‐field system. An explicit RHC controller is obtained by introducing a cost function with two terminal matrices and the conditions that make the system stable are also obtained; that is, when two coupled Lyapunov inequalities are satisfied, the system controlled by RHC is stabilized. Finally, a simulation example is given to verify the effectiveness of the proposed strategy.
“We are exhausted, worn out, and broken”: Understanding the impact of service satisfaction on caregiver well‐being
Authors: Fong Vanessa C. , McLaughlin Janet , Schneider Margaret 
Published: September 2023

AbstractFew studies exist that have examined the impact of service‐related factors and system‐level disruptions (i.e., the pandemic) on families of autistic children in Canada using large sample sizes. To address this gap, the goal of this research was to examine the impact of satisfaction with autism services on caregiver stress, controlling for important demographic variables, such as family income, marital status, and child level of support needs. The impact of navigating and accessing services on parent well‐being was also explored. A total of 1810 primary caregivers of autistic children or youth living in Ontario, Canada completed a survey with both closed‐ and open‐ended questions in the summer of 2021. A hierarchical multiple regression was conducted to examine the impact of satisfaction with autism services on caregiver stress. Open‐ended responses on the survey from a subset of the sample (n = 637) were coded using thematic analysis to understand the impact of navigating and accessing services on parent well‐being. Satisfaction with services significantly predicted caregiver stress after controlling for marital support, family income, and child level of support needs. Qualitative analysis revealed impacts of navigating and accessing services in three areas: (1) Physical, (2) Emotional/Psychological, and (3) Financial Well‐being. Understanding parent perceptions of satisfaction with services can shed light on strategies for improving services that support parent well‐being.
Preparation of silver nanoparticles by Osbeckia stellata aqueous extract via green synthesis approach: Characterization and assessment of their antioxidant, antidiabetic, cytotoxicity, and antibacterial properties
Authors: Baishya Tania , Das Priya , Ashraf Gouhar Jahan , Dua Tarun Kumar , Paul Paramita , Nandi Gouranga , Dutta Ankita , Limbu Divya , Kumar Anoop , Adhikari Manab Deb , Bhattacharya Malay , Sahu Ranabir 
Published: September 2023

AbstractSilver nanoparticles (Ag NPs) via green synthesis using medicinal plants have been widely used in natural product research due to the economical and eco‐friendly properties of NPs. The plant‐derived Ag NPs biosynthesis comprises the interaction between silver nitrate (precursor) and bioactive components of plant extract (reducing agents). In this work, Ag NPs were biosynthesized using Osbeckia stellata leaves aqueous extract. Characterization of Ag NPs was done by using ultraviolet–visible absorption (UV–Vis) spectroscopy, dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), X‐ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy‐dispersive X‐ray analysis (EDX). Further, antioxidant, antidiabetic, cytotoxicity, and antimicrobial activities were evaluated to establish the pharmacological properties of Ag NPs. UV–Vis spectroscopy and FTIR showed an absorption peak of Ag NPs due to the surface plasmonic resonance. In contrast, the particle size in the nanometer range was analyzed by XRD and DLS. The size of the particle was confirmed by the SEM, TEM, and EDX in the nanometer range. This study showed the spherical shape and crystalline nature of NPs. Zeta potential was used to determine the stability of Ag NPs. Biosynthesized Ag NPs showed significantly potent antioxidant, antidiabetic, and cytotoxicity activity. Ag NPs also showed effectiveness against gram‐positive (Escherichia coli) and gram‐negative (Staphylococcus aureus) bacteria in the antimicrobial activity study. The result concluded that these Ag NPs might be used in biomedical and pharmacological fields.
Untersuchungen zur Schub‐Druck‐Tragfähigkeit von Mauerwerk aus kleinformatigen Mauersteinen
Authors: Eisinger Thomas , Fischer Oliver 
Published: September 2023

AbstractDie Beanspruchbarkeit von Mauerwerk bestehend aus kleinformatigen künstlichen Mauersteinen hinsichtlich einer kombinierten Schub‐Druck‐Belastung ist ein komplexes und nicht abschließend erforschtes Themengebiet. Aufgrund der praktischen Relevanz dieser Thematik und aus Gründen der Nachhaltigkeit ist daher weiterhin Forschung zu betreiben, um die bestehenden Wissenslücken schließen zu können. Am Lehrstuhl für Massivbau der Technischen Universität München (TUM) wurden und werden deshalb intensive und umfangreiche theoretische und experimentelle Untersuchungen angestellt mit der Zielsetzung, die Trag‐ und Schädigungsmechanismen von kleinformatigem Mauerwerk, wie es in vielen älteren Bestandsgebäuden vorkommt, für unterschiedlichste Belastungsszenarien und verschiedenste Parameterkombinationen systematisch zu analysieren. Um den versuchstechnischen Aufwand zu minimieren, wurde eine Methode geschaffen, die es anhand von überwiegend kleinmaßstäblichen Untersuchungen an Wandausschnitten in effizienter Weise ermöglicht, das Tragverhalten von kleinformatigem Mauerwerk realitätsnah abzubilden. Mithilfe dieser sog. Einheitszellenmethode konnten im Ergebnis Aussagen zur zweiaxialen Beanspruchbarkeit von historischem Mauerwerk im Hinblick auf den Einfluss von Normalspannungsniveau und Neigungswinkel der diagonalen Kraftresultierenden abgeleitet werden.
Development of a joint derivatization protocol for the unequivocal identification of the monosaccharide composition in four dendrobium polysaccharides and free monosaccharide by GC–MS
Authors: Yang Wei‐Han , Hao Jing‐Wen , Chen Nai‐Dong , Li Jiao 
Published: September 2023

AbstractThe determination of monosaccharides is crucial for studying the structure of polysaccharides and the composition of free monosaccharides in living organisms. Based on previous derivatization gas chromatography–mass spectrometry (GC–MS) methods, we aimed to develop a novel analytical protocol for better quantifying monosaccharides. In this study, sugar alcohol acetylation, saccharonitrile acetylation, silylation and a combination of sugar alcohols acetylation and saccharonitrile acetylation were compared. The optimal method was verified with the monosaccharide determination of four polysaccharides and four free monosaccharides from Dendrobium. The results showed that the novel combined derivatization method was superior to the other three methods in terms of content analysis of monosaccharides. Furthermore, it possessed good linearity (all calibration curves showed relative coefficients ≥ 0.999), sensitivity, precision (relative standard deviation < 2%), and accuracy (recovery, 95.7–105%). Finally, the novel method established in this study was successfully employed in determining the monosaccharide composition of four polysaccharides and four free monosaccharide samples from Dendrobium.
Toward a sustainable business model: A study of market perception and value propositions of stone dust concrete in Thailand
Authors: Janjirawatna Nathatai , Khin Khin Oo Nay Chi , Rakthin Sirisuhk 
Published: September 2023

AbstractThe stone mining and construction sectors are crucial for Thailand's economic advancement. Yet, they face issues such as substantial stone waste accumulation, causing environmental pollution and the resource‐intensive nature of concrete production. Existing studies lack comprehensive coverage of Thailand's specific environmental challenges related to these industries and their sustainable solutions. There is also a knowledge gap concerning region‐specific influences and the relationship between stone dust and concrete sustainability within Thailand's unique geographical and socio‐economic context. Furthermore, sustainable practices in stone dust concrete within Thailand are insufficiently investigated. To bridge these gaps, this study examines the viability of the stone dust concrete business and its potential to mitigate social and environmental challenges. The research reveals alignment between the stone dust concrete business model and stakeholder needs through interviews with industry stakeholders. Subsequently, barriers like the absence of sustainable concrete standards, higher costs, and limited consumer demand for eco‐friendly products are identified.