bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between external and internal doses to the thyroid after the Fukushima Daiichi Nuclear Power Plant accident
Authors: Ishikawa Tetsuo , Ohba Takashi , Hasegawa Arifumi , Akahane Keiichi , Yasumura Seiji , Kamiya Kenji , Suzuki Gen 
Published: January 2023

AbstractTo analyze the association between radiation dose and thyroid cancer after the 2011 Fukushima Daiichi Nuclear Power Plant (FDNPP) accident, external doses have often been used because of the difficulty to estimate internal thyroid doses individually due to the lack of human data. However, no evaluation has been made as to whether external dose is a good surrogate marker for internal thyroid dose individually. This study aimed at analyzing the relationship between external doses and internal thyroid doses estimated by recently developed methodology. For four municipalities affected by the accident, 200 individuals aged under 20 at the time of the accident per municipality were randomly selected, and their external and internal thyroid doses and their ratios were estimated individually. In a separate analysis, median and arithmetic mean values for external thyroid doses estimated for persons of 16 municipalities that included the above four were compared with those for previously estimated internal thyroid doses. The ratios of the median of internal thyroid dose to that of external thyroid dose in these 16 municipalities ranged from 0.56 to 13.8 for 15-year-old children and 0.91 to 21.1 for 1-year-old children. No consistent relationship between external and internal thyroid doses was found in all 16 municipalities. Thus, thyroid doses from both external and internal exposures should be used to analyze the association between radiation dose and thyroid cancer detection rates for persons who lived in Fukushima Prefecture at the time of the FDNPP accident. (240).
Bayesian fusion: scalable unification of distributed statistical analyses
Authors: Dai Hongsheng , Pollock Murray , Roberts Gareth O 
Published: January 2023

Abstract
There has been considerable interest in addressing the problem of unifying distributed analyses into a single coherent inference, which arises in big-data settings, when working under privacy constraints, and in Bayesian model choice. Most existing approaches relied upon approximations of the distributed analyses, which have significant shortcomings—the quality of the inference can degrade rapidly with the number of analyses being unified, and can be substantially biased when unifying analyses that do not concur. In contrast, recent Monte Carlo fusion approach is exact and based on rejection sampling. In this paper, we introduce a practical Bayesian fusion approach by embedding the Monte Carlo fusion framework within a sequential Monte Carlo algorithm. We demonstrate theoretically and empirically that Bayesian fusion is more robust than existing methods.
Catching profound optical flares in blazars
Authors: Bhatta Gopal , Zola Staszek , Drozdz M , Reichart Daniel , Haislip Joshua , Kouprianov Vladimir , Matsumoto Katsura , Sonbas Eda , Caton D , Pajdosz-Śmierciak Urszula , Simon A , Provencal J , Góra Dariusz , Stachowski Grzegorz 
Published: January 2023

ABSTRACT
Flaring episodes in blazars represent one of the most violent processes observed in extra-galactic objects. Studies of such events shed light on the energetics of the physical processes occurring in the innermost regions of blazars, which cannot otherwise be resolved by any current instruments. In this work, we present some of the largest and most rapid flares captured in the optical band in the blazars 3C 279, OJ 49, S4 0954+658, TXS 1156+295, and PG 1553+113. The source flux was observed to increase by nearly ten times within a time-scale of a few weeks. We applied several methods of time series analysis and symmetry analysis. Moreover, we also performed searches for periodicity in the light curves of 3C 279, OJ 49 and PG 1553+113 using the Lomb–Scargle method and found plausible indications of quasi-periodic oscillations (QPOs). In particular, the 33- and 22-day periods found in 3C 279, i.e. a 3:2 ratio, are intriguing. These violent events might originate from magnetohydrodynamical instabilities near the base of the jets, triggered by processes modulated by the magnetic field of the accretion disc. We present a qualitative treatment as the possible explanation for the observed large amplitude flux changes in both the source-intrinsic and source-extrinsic scenarios.
A naive Bayes classifier for identifying Class II YSOs
Authors: Wilson Andrew J , Lakeland Ben S , Wilson Tom J , Naylor Tim 
Published: January 2023

ABSTRACTA naive Bayes classifier for identifying Class II YSOs has been constructed and applied to a region of the Northern Galactic Plane containing 8 million sources with good quality Gaia EDR3 parallaxes. The classifier uses the five features: Gaia G-band variability, WISE mid-infrared excess, UKIDSS and 2MASS near-infrared excess, IGAPS Hα excess, and overluminosity with respect to the main sequence. A list of candidate Class II YSOs is obtained by choosing a posterior threshold appropriate to the task at hand, balancing the competing demands of completeness and purity. At a threshold posterior greater than 0.5, our classifier identifies 6504 candidate Class II YSOs. At this threshold, we find a false positive rate around 0.02 per cent and a true positive rate of approximately 87 per cent for identifying Class II YSOs. The ROC curve rises rapidly to almost one with an area under the curve around 0.998 or better, indicating the classifier is efficient at identifying candidate Class II YSOs. Our map of these candidates shows what are potentially three previously undiscovered clusters or associations. When comparing our results to published catalogues from other young star classifiers, we find between one quarter and three quarters of high probability candidates are unique to each classifier, telling us no single classifier is finding all young stars.
Gravito-turbulence in local disc simulations with an adaptive moving mesh
Authors: Zier Oliver , Springel Volker 
Published: January 2023

ABSTRACTSelf-gravity plays an important role in the evolution of rotationally supported systems such as protoplanetary discs, accretion discs around black holes, or galactic discs, as it can both feed turbulence and lead to gravitational fragmentation. While such systems can be studied in the shearing box approximation with high local resolution, the large density contrasts that are possible in the case of fragmentation still limit the utility of Eulerian codes with constant spatial resolution. In this paper, we present a novel self-gravity solver for the shearing box based on the TreePM method of the moving-mesh code arepo. The spatial gravitational resolution is adaptive, which is important to make full use of the quasi-Lagrangian hydrodynamical resolution of the code. We apply our new implementation to two- and three-dimensional, self-gravitating discs combined with a simple β-cooling prescription. For weak cooling we find a steady, gravito-turbulent state, while for strong cooling the formation of fragments is inevitable. To reach convergence for the critical cooling efficiency above which fragmentation occurs, we require a smoothing of the gravitational force in the two-dimensional case that mimics the stratification of the three-dimensional simulations. The critical cooling efficiency we find, β ≈ 3, as well as the box-averaged quantities characterizing the gravito-turbulent state, agrees well with various previous results in the literature. Interestingly, we observe stochastic fragmentation for β &gt; 3, which slightly decreases the cooling efficiency required to observe fragmentation over the lifetime of a protoplanetary disc. The numerical method outlined here appears well suited to study the problem of galactic discs as well as the magnetized, self-gravitating discs.
galstreams: A library of Milky Way stellar stream footprints and tracks
Authors: Mateu Cecilia 
Published: January 2023

ABSTRACT
Nearly a hundred stellar streams have been found to date around the Milky Way and the number keeps growing at an ever faster pace. Here we present the galstreams library, a compendium of angular position, distance, proper motion, and radial velocity track data for nearly a hundred (95) Galactic stellar streams. The information published in the literature has been collated and homogenized in a consistent format and used to provide a set of features uniformly computed throughout the library: e.g. stream length, end points, mean pole, stream’s coordinate frame, polygon footprint, and pole and angular momentum tracks. We also use the information compiled to analyse the distribution of several observables across the library and to assess where the main deficiencies are found in the characterization of individual stellar streams, as a resource for future follow-up efforts. The library is intended to facilitate keeping track of new discoveries and to encourage the use of automated methods to characterize and study the ensemble of known stellar streams by serving as a starting point. The galstreams library is publicly available as a python package and served at the galstreams GitHub repository.
V994 Herculis: a unique triply eclipsing sextuple star system
Authors: Zasche P , Borkovits T , Jayaraman R , Rappaport S A , Brož M , Vokrouhlický D , Bíró I B , Hegedüs T , Kiss Z T , Uhlař R , Schwengeler H M , Pál A , Mašek M , Howell S B , Dallaporta S , Munari U , Gagliano R , Jacobs T , Kristiansen M H , LaCourse D , Omohundro M , Terentev I , Vanderburg A , Henzl Z , Powell B P , Kostov V B 
Published: January 2023

ABSTRACTWe report the discovery with the Transiting Exoplanet Survey Satellite (TESS) of a third set of eclipses from V994 Herculis (V994 Her, TIC 424508303), previously only known as a doubly eclipsing system. The key implication of this discovery and our analyses is that V994 Her is the second fully characterized (2+2) + 2 sextuple system, in which all three binaries eclipse. In this work, we use a combination of ground-based observations and TESS data to analyse the eclipses of binaries A and B in order to update the parameters of the inner quadruple’s orbit (with a derived period of 1062 ± 2 d). The eclipses of binary C that were detected in the TESS data were also found in older ground-based observations, as well as in more recently obtained observations. The eclipse timing variations of all three pairs were studied in order to detect the mutual perturbations of their constituent stars, as well as those of the inner pairs in the (2 + 2) core. At the longest periods they arise from apsidal motion, which may help constraining parameters of the component stars’ internal structure. We also discuss the relative proximity of the periods of binaries A and B to a 3:2 mean motion resonance. This work represents a step forward in the development of techniques to better understand and characterize multiple star systems, especially those with multiple eclipsing components.
A method to enrich polypeptidyl-tRNAs to capture snapshots of translation in the cell
Authors: Yamakawa Ayako , Niwa Tatsuya , Chadani Yuhei , Kobo Akinao , Taguchi Hideki 
Published: January 2023

AbstractLife depends on proteins, which all exist in nascent states when the growing polypeptide chain is covalently attached to a tRNA within the ribosome. Although the nascent chains, i.e. polypeptidyl-tRNAs (pep-tRNAs), are considered as merely transient intermediates during protein synthesis, recent advances have revealed that they are directly involved in a variety of cell functions, such as gene expression control. An increasing appreciation for fine-tuning at translational levels demands a general method to handle the pep-tRNAs on a large scale. Here, we developed a method termed peptidyl-tRNA enrichment using organic extraction and silica adsorption (PETEOS), and then identify their polypeptide moieties by mass spectrometry. As a proof-of-concept experiment using Escherichia coli, we identified ∼800 proteins derived from the pep-tRNAs, which were markedly biased towards the N-termini in the proteins, reflecting that PETEOS captured the intermediate pep-tRNA population during translation. Furthermore, we observed the changes in the pep-tRNA set in response to heat shock or antibiotic treatments. In summary, PETEOS will complement conventional methods to investigate nascent chains in the cell.
A novel RHH family transcription factor aCcr1 and its viral homologs dictate cell cycle progression in archaea
Authors: Yang Yunfeng , Liu Junfeng , Fu Xiaofei , Zhou Fan , Zhang Shuo , Zhang Xuemei , Huang Qihong , Krupovic Mart , She Qunxin , Ni Jinfeng , Shen Yulong 
Published: January 2023

AbstractCell cycle regulation is of paramount importance for all forms of life. Here, we report that a conserved and essential cell cycle-specific transcription factor (designated as aCcr1) and its viral homologs control cell division in Sulfolobales. We show that the transcription level of accr1 reaches peak during active cell division (D-phase) subsequent to the expression of CdvA, an archaea-specific cell division protein. Cells over-expressing the 58-aa-long RHH (ribbon-helix-helix) family cellular transcription factor as well as the homologs encoded by large spindle-shaped viruses Acidianus two-tailed virus (ATV) and Sulfolobus monocaudavirus 3 (SMV3) display significant growth retardation and cell division failure, manifesting as enlarged cells with multiple chromosomes. aCcr1 over-expression results in downregulation of 17 genes (&gt;4-fold), including cdvA. A conserved motif, aCcr1-box, located between the TATA-binding box and the translation initiation site of 13 out of the 17 highly repressed genes, is critical for aCcr1 binding. The aCcr1-box is present in the promoters and 5′ UTRs of cdvA genes across Sulfolobales, suggesting that aCcr1-mediated cdvA repression is an evolutionarily conserved mechanism by which archaeal cells dictate cytokinesis progression, whereas their viruses take advantage of this mechanism to manipulate the host cell cycle.
Genome-wide mapping of protein–DNA damage interaction by PADD-seq
Authors: Zhu Yongchang , Tan Yuanqing , Li Lin , Xiang Yuening , Huang Yanchao , Zhang Xiping , Yin Jiayong , Li Jie , Lan Fei , Qian Maoxiang , Hu Jinchuan 
Published: January 2023

AbstractProtein–DNA damage interactions are critical for understanding the mechanism of DNA repair and damage response. However, due to the relatively random distributions of UV-induced damage and other DNA bulky adducts, it is challenging to measure the interactions between proteins and these lesions across the genome. To address this issue, we developed a new method named Protein-Associated DNA Damage Sequencing (PADD-seq) that uses Damage-seq to detect damage distribution in chromatin immunoprecipitation-enriched DNA fragments. It is possible to delineate genome-wide protein–DNA damage interactions at base resolution with this strategy. Using PADD-seq, we observed that RNA polymerase II (Pol II) was blocked by UV-induced damage on template strands, and the interaction declined within 2 h in transcription-coupled repair-proficient cells. On the other hand, Pol II was clearly restrained at damage sites in the absence of the transcription–repair coupling factor CSB during the same time course. Furthermore, we used PADD-seq to examine local changes in H3 acetylation at lysine 9 (H3K9ac) around cisplatin-induced damage, demonstrating the method's broad utility. In conclusion, this new method provides a powerful tool for monitoring the dynamics of protein–DNA damage interaction at the genomic level, and it encourages comprehensive research into DNA repair and damage response.
Structure and functional determinants of Rad6–Bre1 subunits in the histone H2B ubiquitin-conjugating complex
Authors: Shukla Prakash K , Bissell Jesse E , Kumar Sanjit , Pokhrel Srijana , Palani Sowmiya , Radmall Kaitlin S , Obidi Onyeka , Parnell Timothy J , Brasch Julia , Shrieve Dennis C , Chandrasekharan Mahesh B 
Published: January 2023

AbstractThe conserved complex of the Rad6 E2 ubiquitin-conjugating enzyme and the Bre1 E3 ubiquitin ligase catalyzes histone H2B monoubiquitination (H2Bub1), which regulates chromatin dynamics during transcription and other nuclear processes. Here, we report a crystal structure of Rad6 and the non-RING domain N-terminal region of Bre1, which shows an asymmetric homodimer of Bre1 contacting a conserved loop on the Rad6 ‘backside’. This contact is distant from the Rad6 catalytic site and is the location of mutations that impair telomeric silencing in yeast. Mutational analyses validated the importance of this contact for the Rad6–Bre1 interaction, chromatin-binding dynamics, H2Bub1 formation and gene expression. Moreover, the non-RING N-terminal region of Bre1 is sufficient to confer nucleosome binding ability to Rad6 in vitro. Interestingly, Rad6 P43L protein, an interaction interface mutant and equivalent to a cancer mutation in the human homolog, bound Bre1 5-fold more tightly than native Rad6 in vitro, but showed reduced chromatin association of Bre1 and reduced levels of H2Bub1 in vivo. These surprising observations imply conformational transitions of the Rad6–Bre1 complex during its chromatin-associated functional cycle, and reveal the differential effects of specific disease-relevant mutations on the chromatin-bound and unbound states. Overall, our study provides structural insights into Rad6–Bre1 interaction through a novel interface that is important for their biochemical and biological responses.
Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding
Authors: Bruekner Susanne R , Pieters Wietske , Fish Alexander , Liaci A Manuel , Scheffers Serge , Rayner Emily , Kaldenbach Daphne , Drost Lisa , Dekker Marleen , van Hees-Stuivenberg Sandrine , Delzenne-Goette Elly , de Konink Charlotte , Houlleberghs Hellen , Dubbink Hendrikus Jan , AlSaegh Abeer , de Wind Niels , Förster Friedrich , te Riele Hein , Sixma Titia K 
Published: January 2023

AbstractThe DNA mismatch repair protein MutSα recognizes wrongly incorporated DNA bases and initiates their correction during DNA replication. Dysfunctions in mismatch repair lead to a predisposition to cancer. Here, we study the homozygous mutation V63E in MSH2 that was found in the germline of a patient with suspected constitutional mismatch repair deficiency syndrome who developed colorectal cancer before the age of 30. Characterization of the mutant in mouse models, as well as slippage and repair assays, shows a mildly pathogenic phenotype. Using cryogenic electron microscopy and surface plasmon resonance, we explored the mechanistic effect of this mutation on MutSα function. We discovered that V63E disrupts a previously unappreciated interface between the mismatch binding domains (MBDs) of MSH2 and MSH6 and leads to reduced DNA binding. Our research identifies this interface as a ‘safety lock’ that ensures high-affinity DNA binding to increase replication fidelity. Our mechanistic model explains the hypomorphic phenotype of the V63E patient mutation and other variants in the MBD interface.
Association between β-carotene supplementation and risk of cancer: a meta-analysis of randomized controlled trials
Authors: Zhang Yulin , Yang Jiaqi , Na Xiaona , Zhao Ai 
Published: January 2023

Abstract

Context
β-Carotene, which is derived from most fruits and vegetables, is the most common type of carotenes. Existing studies have demonstrated that β-carotene is associated with some positive health outcomes. However, results about the effects of supplemental β-carotene on cancer are inconsistent.

Objective
To determine the association between supplemental β-carotene intake and the risk of cancers.

Data sources
Eight databases (PubMed, Web of Science, Embase, Cochrane, China National Knowledge Infrastructure, Wangfang, China Science and Technology Journal Database, and Chinese Biomedical Literature Database) were systematically searched until September 2022.

Data extraction
Only reports from randomized controlled trials in which an association between supplemental β-carotene intake and the risk of cancer was found were included in the meta-analysis.

Data analysis
A total of 18 eligible studies based on 8 different randomized controlled trials were included in the meta-analysis, with varying sample sizes from 391 to 39 876 participants. There was no significant association between supplemental β-carotene intake and overall cancer incidence rate after synthesizing all the results (risk ratio [RR]: 1.02; 95% confidence interval [CI], 0.99–1.05). Results from subgroup analysis indicated that intake of supplemental β-carotene significantly increased the risk of lung cancer (RR: 1.19; 95%CI: 1.08–1.32), whereas no significant associations were observed for other site-specific cancers. In addition, smokers and the subgroup of participants with only low-dose β-carotene intake had a risk increment of cancer if they took supplemental β-carotene (RR: 1.16; 95%CI: 1.05–1.29).

Conclusion
β-Carotene supplementation has no beneficial or harmful effect on cancer incidence; moreover, it might have potentially harmful effects on lung cancer, especially for people who smoke. On the basis of the evidence from this study, supplemental intake of β-carotene is not recommended for preventing cancer, and the establishment of a tolerable upper intake level of β-carotene should be considered.
Greek Death Rituals and Lament
Authors: Holst-Warhaft Gail 
Published: January 2023

Abstract
Research into Greek death rituals and laments was begun in the nineteenth century in an attempt to establish continuity between modern and ancient Greece. Despite valuable insights, the approach biased understanding of laments and other death rituals. Later anthropological studies of Greek regions and villages built up a detailed picture of customs and beliefs about death, showing that, despite regional variations and modernization, they follow predictable patterns from village to village and are observed in immigrant communities in the cities. Revivals of lament and lament therapy indicate new trends in lament research but are far removed from the ritual and religious context that created them. Comparative studies of Balkan lament are rare and would benefit the field.
Receiving the Vision of Vatican II in Oceania
Authors: Rush Ormond 
Published: January 2023

Abstract
This chapter will explore the reception of Vatican II in the widely diverse geographical, cultural, and ecclesiastical region called Oceania. It will be demonstrated that an understanding of the reception of Vatican II throughout the local churches of Oceania can be conceived as taking place on three levels, based on Alois Grillmeier’s framework of conciliar reception in the early Church: official reception (by the hierarchy); theological reception (by theologians); and spiritual reception (by the baptized faithful). These three levels are important, since the hierarchy, theologians, and lay faithful have distinct but complementary roles in the Church. This chapter will also consider the council’s communio ecclesiology as another useful criterion for evaluating and assessing how deeply the conciliar vision has been received at these three levels.