bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative analysis of an endoplasmic reticulum stress‐related signature in multiple myeloma
Authors: Wu Chengyu , Liu Mei , Liu Jia , Jia Mingyuan , Zeng Xinyi , Fu Ze , Geng Yanlai , He Ziqi , Zhang Xian , Yan Hua 
Published: September 2023

AbstractBackgroundMultiple myeloma (MM) is a malignancy in which plasma cells proliferate abnormally, and it remains incurable. The cells are characterized by high levels of endoplasmic reticulum stress (ERS) and depend on the ERS response for survival. Thus, we aim to find an ERS‐related signature of MM and assess its diagnostic value.MethodsWe downloaded three datasets of MM from the Gene Expression Omnibus database. After identifying ERS‐related differentially expressed genes (ERDEGs), we analyzed them using Gene Ontology enrichment analysis. A protein–protein interaction network, a transcription factor–mRNA network, a miRNA–mRNA network and a drug–mRNA network were constructed to explore the ERDEGs. The clinical application of these genes was identified by calculating the infiltration of immune cells and using receiver operating characteistic analyses. Finally, qPCR was performed to further confirm the roles of ERDEGs.ResultsWe obtained nine ERDEGs of MM. Gene Ontology enrichment indicated that the ERDEGs played a role in the endoplasmic reticulum membrane. Additionally, the protein–protein interaction network showed interaction among the ERDEGs, and there were 20 proteins, 107 transcription factors, 42 drugs or molecular compounds and 51 miRNAs which were likely to interact with the nine genes. In addition, immune cell infiltration analyses showed that there was a strong correlation between the nine genes and immune cells, and these potential biomarkers exhibited good diagnostic values. Finally, the expression of ERDEGs in MM cells was different from that in healthy donor samples.ConclusionThe nine ERS‐related genes, CR2, DHCR7, DNAJC3, KDELR2, LPL, OSBPL3, PINK1, VCAM1 and XBP1 are potential biomarkers of MM, and this supports further clinical development of the diagnosis and treatment of MM.
Ontogenetic skull variation in a shovel‐headed amphisbaenian species
Authors: Hohl Leandro dos S. L. , Azorit Concepción , Vassallo Aldo I. , Casinos Adrià , Machado Alessandra S. , Lopes Ricardo T. , Rocha‐Barbosa Oscar 
Published: September 2023

AbstractLeposternon microcephalum is a species belonging to the Amphisbaenia, a group of burrowing reptiles. Amphisbaenia present various morphological and physiological adaptations that allow them to penetrate the ground and live underground, through a system of galleries and permanent chambers that they build themselves. Among the morphological adaptations in this group, those of the skull stand out as it serves as the main excavation tool. Four basic skull shapes are recognized: rounded, keeled, shovel‐shaped, and spade‐shaped. The skull of L. microcephalum belongs to this last type, which is considered the most specialized. The species inhabits soils that are highly compacted and difficult to penetrate. Among the species of Leposternon present in South America, L. microcephalum has the widest distribution, being found in all Brazilian biomes and neighboring countries such as Bolivia, Argentina, Paraguay, and Uruguay. The analysis of the skull of this species was carried out using three‐dimensional geometric morphometrics (3D‐GMM), a technique that allows comparative analysis, through robust statistical methods, of shape and its variations, using Cartesian coordinate data from a configuration of homologous landmarks. The technique allows the size and shape components of a structure to be analyzed separately. From an ontogenetic point of view, this methodology had also been used to investigate variations in Cynisca leucura, a member of the Amphisbaenidae with a rounded head. Our hypothesis is that the patterns of morphological differentiation in the skull, mainly in the intermediate and occipital regions, are similar in different Amphisbaenia species. Therefore, the objective of this study was to analyze cranial morphological variations in an ontogenetic series of L. microcephalum using 3D‐GMM. Computed Tomographic scans of 13 specimens were analyzed: juveniles (N = 8) and adults (N = 5), based on 20 landmarks that characterize the skull. Principal components and regression analyses between shape (dependent variable) and size (independent variable) showed a clear difference between the cranial morphological pattern of juvenile individuals and that of adults. For instance, young specimens tend to have a dorsoventrally tall neurocranium, with the tip of the snout more anteriorly oriented and its dorsal border subtly curved. Dorsally, the parietal region is thicker and smoothly dome‐shaped in juveniles. As in C. leucura, the variation was strongly correlated with the size change from juvenile to adult, indicating a dominant role for ontogenetic allometry in determining skull shape.
Clinical Evaluation of Cystic Renal Masses With Bosniak Classification by Contrast‐Enhanced Ultrasound and Contrast‐Enhanced Computer Tomography
Authors: Lan Li , Yang Yu , Xu Zi‐qiang , Jin Xuan‐chen , Huang Ka‐te , Chen Yu‐xuan , Yang Chen‐xing , Zhou Man 
Published: September 2023

ObjectivesThe study aims to compare retrospectively three clinically applied methods for the diagnostic performance of cystic renal masses (CRMs) by contrast‐enhanced ultrasound (CEUS) and contrast‐enhanced computer tomography (CECT) with Bosniak classification system.MethodsA total of 52 cases of Bosniak II–IV CRMs in 49 consecutive patients were diagnosed from January 2013 to July 2022 and their data were analyzed. All patients had been subjected to CEUS and CECT simultaneously. Pathological diagnoses and masses stability were used as standard references to determine whether lesions were malignant or benign. Then 49 CRMs only with pathologic results were classified into group 1 and 2.ResultsA total of 52 CRMs in 49 enrolled patients were classified into 8 category II, 16 category IIF, 15 category III, and 13 category IV by CEUS (EFSUMB 2020), 10 category II, 13 category IIF, 16 category III, and 13 category IV by CEUS (V2019), while 15 category II, 9 category IIF, 13 category III, and 15 category IV by CECT (V2019). Pathological results and masses stability longer than 5 years follow‐up performed substantially for CEUS (EFSUMB 2020), CEUS (V2019), and CECT (V2019) (kappa values were 0.696, 0.735, and 0.696, respectively). Among 49 pathologic approving CRMs, wall/septation thickness ≥4 mm, wall/septation thickness, presence of enhancing nodule and the diameter were found to be statistically significant for malignancy. Twenty‐two malignant masses were correctly diagnosed by CEUS (V2019), while 21 malignant masses were both correctly diagnosed by CEUS (EFSUMB 2020) and CECT (V2019), and 1 mass was misdiagnosed.ConclusionsBosniak classification of EFSUMB 2020 version might be as accurate as version 2019 CEUS and version 2019 CECT in diagnosing CRMs, and CEUS is found to have an excellent safety profile in dealing with clinical works.
Clinical significance of abdominal computed tomography and colonoscopy in the evaluation of phlebosclerotic colitis
Authors: Wang Pin‐Yi , Weng Kung‐Hsun , Liou Jyun‐Yan , Kuo Hsing‐Tao , Ho Chung‐Han , Sheu Ming‐Jen 
Published: September 2023

AbstractClinical manifestations of phlebosclerotic colitis (PC) exhibit significant variability, necessitating diverse treatment strategies depending on disease severity. However, there is limited research exploring the relationship between imaging findings and disease severity. Hence, this retrospective study aimed to analyze the correlation between computed tomography (CT) findings, colonoscopic features, and disease severity. This study compared the abdominal CT characteristics, colonoscopy findings, and treatment modalities of 45 PC patients. CT images were assessed for the severity of mesenteric venous calcification, maximum colonic wall thickness, number of involved colonic segments, and presence of pericolic inflammation. Colonoscopic images were assessed for dark purple discoloration mucosa, erosive and ulcerative lesions, mucosal edema, luminal narrowing, and the number of involved colonic segments. In addition, patients were categorized into three groups: the observation (n = 15), medical treatment (n = 19), and operation (n = 11) groups. In CT images, a significant difference in pericolic inflammation (p = 0.039) was observed among groups. Further, significant differences in dark purple discoloration mucosa (p = 0.033), erosive or ulcerative lesions (p < 0.001), mucosal edema (p < 0.001), luminal narrowing (p = 0.012), and the number of involved colonic segments (p = 0.001) were observed in colonoscopy. Moreover, we found positive correlations between CT and colonoscopy features. In conclusion, CT manifestations and colonoscopy findings exhibited correlation with disease severity in PC. When limited to one diagnostic tool, observations from that tool can infer potential manifestations of the alternative tool.
Understanding drivers of the spatial variability of soil organic carbon in China's terrestrial ecosystems
Authors: Li Ya‐Ting , Yang Ren‐Min , Zhang Xin , Xu Lu , Zhu Chang‐Ming 
Published: September 2023

AbstractThe carbon balance of the global ecosystems is significantly influenced by the soil organic carbon (SOC) pool in China's terrestrial ecosystems. Nevertheless, the current understanding of the main controlling factors of SOC in different ecosystems and their discrepancies is limited. The goal of this research was to better understand the human and environmental variables affecting SOC in China's terrestrial ecosystems. We designed a conceptual framework using 2674 samples collected from four ecosystems (grasslands, shrublands, wetlands, and croplands) in China during the 2000–2014 period, combining geodetector and multiple regression (MR) approaches to investigate the effects of environmental conditions, human activity, and their interplay on surface SOC (0–20 cm). Results showed that there were large discrepancies in the strength of influencing factors among different ecosystems. Total nitrogen (TN), mean annual temperature (MAT), and bulk density (BD) were the major factors influencing SOC in grasslands. BD, TN, and pH dominated in shrublands. For wetlands, SOC stocks were primarily attributed to maximum temperature (TMMX), MAT, and potential evapotranspiration (PET). Croplands are predominantly controlled by minimum temperature (TMMN), MAT, and TN. These results highlight that natural factors, particularly climatic and soil characteristics, were the dominant factors controlling SOC stocks in China's terrestrial ecosystems. This work also highlights that the interaction of two influencing factors, especially, pairs of soil characteristics factors, pairs of climate and soil characteristics factors, can well explain the drivers of SOC on the surface soil in China. Our study emphasizes the spatial heterogeneity of the factors that influence SOC in terrestrial ecosystems, enhancing knowledge of SOC at the national level, and providing the guideline for devising better policy to improve C sequestration and mitigate climate changes.
Single‐cell RNA sequencing of retina revealed novel transcriptional landscape in high myopia and underlying cell‐type‐specific mechanisms
Authors: Yao Yunqian , Chen Zhenhua , Wu Qingfeng , Lu Yi , Zhou Xingtao , Zhu Xiangjia 
Published: September 2023

AbstractHigh myopia is a leading cause of blindness worldwide with increasing prevalence. Retina percepts visual information and triggers myopia development, but the underlying etiology is not fully understood because of cellular heterogeneity. In this study, single‐cell RNA sequencing analysis was performed on retinas of mouse highly myopic and control eyes to dissect the involvement of each cell type during high myopia progression. For highly myopic photoreceptors, Hk2 inhibition underlying metabolic remodeling from aerobic glycolysis toward oxidative phosphorylation and excessive oxidative stress was identified. Importantly, a novel Apoe+ rod subpopulation was specifically identified in highly myopic retina. In retinal neurons of highly myopic eyes, neurodegeneration was generally discovered, and the imbalanced ON/OFF signaling driven by cone‐bipolar cells and the downregulated dopamine receptors in amacrine cells were among the most predominant findings, indicating the aberrant light processing in highly myopic eyes. Besides, microglia exhibited elevated expression of cytokines and TGF‐β receptors, suggesting enhanced responses to inflammation and the growth‐promoting states involved in high myopia progression. Furthermore, cell–cell communication network revealed attenuated neuronal interactions and increased glial/vascular interactions in highly myopic retinas. In conclusion, this study outlines the transcriptional landscape of highly myopic retina, providing novel insights into high myopia development and prevention.
TMM: A comprehensive CAD system for hepatic fibrosis 5‐grade METAVIR staging based on liver MRI
Authors: Liu Hui , Fu Yaqing , Guo Dongmei , Li Shuo , Jin Yilin , Zhang Aoran , Wu Chengjun 
Published: September 2023

AbstractBackgroundPrecise staging of hepatic fibrosis with MRI is necessary as it can assist precision medicine. Computer aided diagnosis (CAD) system with distinguishing radiomics features and radiologists domain knowledge is expected to obtain 5‐grade meta‐analysis of histological data in viral hepatitis (METAVIR) staging.PurposeThis study aims to obtain the precise staging of hepatic fibrosis based on MRI as it predicts the risk of future liver‐related morbidity and the need for treatment, monitoring and surveillance. Based on METAVIR score, fibrosis can be divided into five stages. Most previous researches focus on binary classification, such as cirrhosis versus non‐cirrhosis, early versus advanced fibrosis, and substantial fibrosis or not. In this paper, a comprehensive CAD system TMM is proposed to precisely class hepatic fibrosis into five stages for precision medicine instead of the common binary classification.MethodsWe propose a novel hepatic fibrosis staging CAD system TMM which includes three modules, Two‐level Image Statistical Radiomics Feature (TISRF), Monotonic Error Correcting Output Codes (MECOC) and Monotone Multiclassification with Deep Forest (MMDF). TISRF extracts radiomics features for distinguishing different hepatic fibrosis stages. MECOC is proposed to encode monotonic multiclass by making full use of the progressive severity of hepatic fibrosis and increase the fault tolerance and error correction ability. MMDF combines multiple Deep Forest network to ensure the final five‐class classification, which can achieve more precise classification than the common binary classification. The performance of the proposed hepatic fibrosis CAD system is tested on the hepatic data collected from our rabbits models of fibrosis.ResultsA total of 140 regions of interest (ROI) are selected from MRI T1W of liver fibrosis models in 35 rabbits with F0(n = 16), F1(n = 28), F2(n = 29), F3(n = 44) and F4(n = 23). The performance is evaluated by five‐fold cross‐validation. TMM can achieve the highest total accuracy of 72.14% for five fibrosis stages compared with other popular classifications. To make a comprehensive comparison, a binary classification experiment have been carried out.ConclusionsT1WI can obtain precise staging of hepatic fibrosis with the help of comprehensive CAD including radiomics features extraction inspired by radiologists, monotonic multiclass according to the severity of hepatic fibrosis, and deep learning classification.
Delays Starting Postoperative Radiotherapy Among Head and Neck Cancer Patients: A Systematic Review and Meta‐analysis
Authors: Duckett Kelsey A. , Kassir Mohamed Faisal , Nguyen Shaun A. , Brennan Emily A. , Chera Bhishamjit S. , Sterba Katherine R. , Hughes Halbert Chanita , Hill Elizabeth G. , McCay Jessica , Puram Sidharth V. , Sandulache Vlad C. , Kahmke Russel , Ramadan Salma , Nussenbaum Brian , Alberg Anthony J. , Graboyes Evan M. 
Published: September 2023

AbstractObjectiveInitiating postoperative radiotherapy (PORT) within 6 weeks (42 days) of surgery is the first and only Commission on Cancer (CoC) approved quality metric for head and neck squamous cell carcinoma (HNSCC). No study has systematically reviewed nor synthesized the literature to establish national benchmarks for delays in starting PORT.Data SourcesFollowing Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines, we performed a systematic review of PubMed, Scopus, and CINAHL.Review MethodsStudies that described time‐to‐PORT or PORT delays in patients with HNSCC treated in the United States after 2003 were included. Meta‐analysis of proportions and continuous measures was performed on nonoverlapping datasets to examine the pooled frequency of PORT delays and time‐to‐PORT.ResultsThirty‐six studies were included in the systematic review and 14 in the meta‐analysis. Most studies utilized single‐institution (n = 17; 47.2%) or cancer registry (n = 16; 44.4%) data. Twenty‐five studies (69.4%) defined PORT delay as >6 weeks after surgery (the definition utilized by the CoC and National Comprehensive Cancer Network Guidelines), whereas 4 (11.1%) defined PORT delay as a time interval other than >6 weeks, and 7 (19.4%) characterized time‐to‐PORT without defining delay. Meta‐analysis revealed that 48.6% (95% confidence interval [CI], 41.4‐55.9) of patients started PORT > 6 weeks after surgery. Median and mean time‐to‐PORT were 45.8 (95% CI, 42.4‐51.4 days) and 47.4 days (95% CI, 43.4‐51.4 days), respectively.ConclusionDelays in initiating guideline‐adherent PORT occur in approximately half of patients with HNSCC. These meta‐analytic data can be used to set national benchmarks and assess progress in reducing delays.
Body image dissatisfaction and academic buoyancy in adolescents: The mediating roles of social anxiety and basic psychological needs satisfaction
Authors: Zhao Dan , Bai Baoyu , Bai Chengzhi 
Published: September 2023

AbstractAcademic buoyancy has a significant and stable effect on adolescent academic achievement. Thus, it is vital to examine the antecedent variables of academic buoyancy. However, little research has examined the effect of body image dissatisfaction on academic buoyancy. This study investigates the link between body image dissatisfaction and academic buoyancy in Chinese adolescents, focusing on the mediating roles of social anxiety and basic psychological needs satisfaction. Using the Negative Physical Self Scale, the Social Anxiety Scale for Adolescents, the Basic Psychological Needs Satisfaction Scale, and the Academic Buoyancy Scale, questionnaires were administered to 516 high school students in Henan and Hunan provinces in China. The results revealed that: (1) basic psychological needs satisfaction mediated the relationship between body image dissatisfaction and academic buoyancy among Chinese adolescents; (2) social anxiety and basic psychological needs satisfaction had a serial mediating role between body image dissatisfaction and academic buoyancy among Chinese adolescents. This research provides a pioneering exploration of the effect of body image dissatisfaction on academic buoyancy and its mechanisms. Implications for secondary school education practices and directions for future research are discussed.
Automated hanging water column for characterizing water retention and hysteresis of coarse‐textured porous media
Authors: Dixon Chihiro , Blakeslee Adam , Mills Melanie , Sheng Wenyi , Jones Scott B. 
Published: September 2023

AbstractModeling and characterizing hysteretic water retention is critical for predicting hydrodynamic behavior in porous media. This is especially true in coarse‐textured media used in geotechnical engineering, greenhouse, and landscape industries, where subtle changes in water status may lead to plant stress. However, based on the traditional hanging water column method, water retention measurements are laborious and time consuming because of the stepwise manual water potential adjustments and wait‐time requirements for equilibrium conditions to develop. Therefore, we designed and fabricated an automated system to collect wetting‐ and drying‐water retention data from coarse porous media. The basic system consisted of (1) a compound pressure transducer (± 70‐cm range) providing both the porous medium's volumetric water content (θ) and matric potential (h) determinations, (2) a 70‐cm linear actuator to vertically position a 50‐mL burette, and (3) a diffuse laser distance sensor positioned by a 10‐cm linear actuator to monitor the burette's vertical position relative to the sample position. This automated system determined the initial drying process beginning with a fully saturated sample (h = 0 cm) and determined subsequent wetting‐ and drying‐water retention curves. Our automated water retention measurements in quartz sand (ASTM C778‐21) exhibited maximum‐ and minimum‐standard deviation in θ of 0.013 and 0.00044 cm3 cm−3, respectively. Parameters of the hysteretic water retention model of quartz sand were characterized using repeated measurements. Results of this research included the creation of an automated water retention system and the well‐characterized hydraulic parameters for the original well‐graded and narrowly sieved particle sizes of quartz sand.
Base station location generation algorithm for satellite‐terrestrial co‐existence studies
Authors: Singh Bhadouria Vijay , Chakraborty Sucharita , Buch Saket D. , Chandra Bera Subhash 
Published: September 2023

SummaryThe enormous growth of mobile broadband traffic is a catalyst for expanding terrestrial communication systems and their integration with satellite communication systems. This results in sharing frequencies allocated to satellite communication systems with terrestrial systems. As this can lead to interference between the incumbent and the upcoming service, coexistence studies are conducted. In the case of sharing satellite uplink frequencies with terrestrial communication systems, interference from base stations (BSs) is dominant. While there are methods to estimate the number of BSs that may be deployed, it is unclear where the BSs will be located. The BS locations play a pivotal role in interference calculation, as the values of link budget parameters are highly dependent on the longitude and latitude of interfering transmitters. This article presents an intelligent method which balances network capacity and coverage for simulating base stations (BSs) in coexistence studies. A realistic BS distribution is generated using weighted K‐means clustering (WKMC) algorithm and incorporating population density along with Haversine distance. The paper provides a case study of co‐frequency, co‐coverage interference in the satellite uplink in the C‐band to demonstrate the impact of BS distribution on the results of coexistence studies. This paper will find applications in upcoming frequency sharing and coexistence studies and the design of integrated satellite‐terrestrial communication networks.