bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinetic Equilibrium of Two-dimensional Force-free Current Sheets
Authors: An Xin , Artemyev Anton , Angelopoulos Vassilis , Runov Andrei , Kamaletdinov Sergey 
Published: July 2023

Abstract
Force-free current sheets are local plasma structures with field-aligned electric currents and approximately uniform plasma pressures. Such structures, widely found throughout the heliosphere, are sites for plasma instabilities and magnetic reconnection, the growth rate of which is controlled by the structure’s current-sheet configuration. Despite the fact that many kinetic equilibrium models have been developed for one-dimensional force-free current sheets, their two-dimensional (2D) counterparts, which have a magnetic field component normal to the current sheets, have not received sufficient attention to date. Here, using particle-in-cell simulations, we search for such 2D force-free current sheets through relaxation from an initial, magnetohydrodynamic equilibrium. Kinetic equilibria are established toward the end of our simulations, thus demonstrating the existence of kinetic force-free current sheets. Although the system currents in the late equilibrium state remain field aligned as in the initial configuration, the velocity distribution functions of both ions and electrons systematically evolve from their initial drifting Maxwellians to their final time-stationary Vlasov state. The existence of 2D force-free current sheets at kinetic equilibrium necessitates future work in discovering additional integrals of motion of the system, constructing the kinetic distribution functions, and eventually investigating their stability properties.
Facilitating a Virtual International Experience for Undergraduate Students: Creating Global Awareness and Connection
Authors: Kumpula Renee S. , Krumwiede Kelly A. 
Published: July 2023

Background:
Preparing nursing students for practice is supported by developing a global perspective of health care delivery models. However, many schools of nursing and students lack the resources for study abroad.

Method:
Using a virtual stay-in place model, 42 international students applied an evidenced-based approach to study statistics, research, transitions in care, and elder care models that supported collaboration among peers from Austria, Switzerland, Chile, the United Kingdom, and the United States. Students explored social, economic, and reimbursement factors not encountered in the typical classroom.

Results:
Student beliefs and perspectives changed after completing a program with global peers. Survey results and themes in reflection papers indicated increased ability to conceptualize content in new ways, including holistic elder care, cultural practices and reimbursement options, and effects on future practice.

Conclusion:

Virtual international learning experiences are an effective education innovation that allows student to connect and learn from one another using a stay-in place model.

[
J Nurs Educ
. 2023;62(11):647–649.]
IL-27 Gene Therapy Induces Stat3-Mediated Expansion of CD11b+Gr1+ Myeloid Cells and Promotes Accumulation of M1 Macrophages in the Tumor Microenvironment
Authors: Zhu Jianmin , Yu Jianyu , Hu Aiyan , Liu Jin-Qing , Pan Xueliang , Xin Gang , Carson William E , Li Zihai , Yang Yiping , Bai Xue-Feng 
Published: July 2023

Abstract
IL-27 is a pleiotropic cytokine that exhibits stimulatory/regulatory functions on multiple lineages of immune cells and has a potential to be used as a therapeutic for cancer. We have recently demonstrated that administration of IL-27 producing adeno-associated virus (AAV-IL-27) exhibits potent inhibition of tumor growth in mouse models. In this study, we demonstrate that AAV-IL-27 treatment leads to significant expansion of CD11b+Gr1+ myeloid cells. AAV-IL-27–induced expansion of CD11b+Gr1+ cells is IL-27R–dependent and requires Stat3 signaling, but it is inhibited by Stat1 signaling. AAV-IL-27 treatment does not increase the self-renewal capacity of CD11b+Gr1+ cells but induces significant expansion of Lin−Sca1+c-Kit+ (LSK) and granulocyte–monocyte progenitor cells. Despite exhibiting significant suppression of T cells in vitro, IL-27–induced CD11b+Gr1+ cells lost the tumor-promoting activity in vivo and overall play an antitumor role. In tumors from AAV-IL-27–treated mice, CD11b+Gr1+ cells are largely F4/80+ and express high levels of MHC class I/II and M1 macrophage markers. Thus, IL-27 gene therapy induces Stat3-mediated expansion of CD11b+Gr1+ myeloid cells and promotes accumulation of M1 macrophages in the tumor microenvironment.
Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-α–Mediated Inflammation
Authors: Lou Yunwei , Jiang Shan , Song Miaomiao , Wang Han , Han Meijuan , Tian Xueqin , Zhao Yuxin , Gao Jingtao , Song Yaru , Ma Shujun , Zhao Peiqing , Zheng Qianqian , Niu Zhiyuan , Zhang Wen , Chang Tingmin , Chen Youhai H , Wang Hui 
Published: July 2023

Abstract
Intestinal epithelial cells (IECs) at the internal/external interface orchestrate the mucosal immune response, and IEC dysfunction has been linked to multiple inflammatory diseases, including inflammatory bowel disease. In this study, we found that a member of the TNF-α–induced protein 8 (TNFAIP8 or TIPE) family called TIPE1 is indispensable for maintaining epithelial cell barrier integrity and homeostasis under inflammatory conditions. TIPE1-deficient mice, or chimeric mice that were deficient in TIPE1 in their nonhematopoietic cells, were more sensitive to dextran sulfate sodium–induced experimental colitis; however, TIPE1 deficiency had no impact on the development of inflammation-associated and sporadic colorectal cancers. Mechanistically, TIPE1 prevented experimental colitis through modulation of TNF-α–dependent inflammatory response in IECs. Importantly, genetic deletion of both TIPE1 and its related protein TNFAIP8 in mice led to the development of spontaneous chronic colitis, indicating that both of these two TIPE family members play crucial roles in maintaining intestinal homeostasis. Collectively, our findings highlight an important mechanism by which TIPE family proteins maintain intestinal homeostasis and prevent inflammatory disorders in the gut.
Test-Retest Reliability and Reliable Change Index of Mobile Application Neurocognitive Testing Among Middle and High School Athletes
Authors: Hashida Kumiko , Lee JongSoo , Furutani Troy , Tsushima William T. , Tamura Kaori 
Published: July 2023

Context
A mobile application neurocognitive assessment has been used in place of equipment-intensive computerized neurocognitive-assessment protocols. A previous study showed high to very high test-retest reliability of neurocognitive assessment using the mobile application in healthy adults, but no researchers have explored test-retest reliability, reliable change indices (RCIs), and sex effects in middle school and high school populations when conducted 1 year apart.

Objectives
To examine the test-retest reliability and RCIs of baseline data collected at 2 time points approximately 1 year apart using a mobile application neurocognitive test in middle school and high school athletes. The secondary purpose was to investigate sex differences in neurocognitive measures.

Design
Cross-sectional study.

Setting
Institution.

Patients or Other Participants
A total of 172 middle school and high school healthy student-athletes (mean age = 13.78 ± 1.59 years).

Main Outcome Measure(s)
Mobile application neurocognitive test scores (reaction time, impulse control, inspection, and memory).

Results
Neurocognitive measures had low test-retest reliability across a 1-year time period in the middle and high school settings. Upon retesting, reaction time and inspection time improved in both middle and high school athletes, and impulse control improved in middle school athletes. More athletes in middle school showed RCI improvements compared with high school athletes. Although both males and females demonstrated improvements in neurocognitive measures throughout adolescence, males outperformed females in reaction time and impulse control.

Conclusions
A mobile application neurocognitive test displayed unacceptably low test-retest reliability, most likely due to the cognitive development occurring throughout adolescence. Additionally, significant RCIs were noted. These naturally occurring improvements due to cognitive development could mask postconcussion deficits. Age and sex warrant consideration with respect to the neurocognitive performance of middle and high school athletes.
Determinants of Intention to Disclose Musculoskeletal Injury in Adolescent Athletes
Authors: Cheever Kelly Martell , Dewig Derek , Nedimyer Aliza K. , Register-Mihalik Johna K. , Kossman Melissa K. 
Published: July 2023

Context
Although research indicates that the key to minimizing the effect of musculoskeletal injury, improving care, and mitigating long-term effects is to improve early injury care seeking, little is known about barriers to early musculoskeletal injury disclosure and care seeking.

Objective
To identify which determinants predicted sport-related musculoskeletal (MSK) injury disclosure by adolescent athletes.

Design
Cross-sectional study.

Setting
Online survey.

Patients or Other Participants
A total of 564 adolescent athletes (58% male, age = 15.81 ± 1.8 years).

Main Outcome Measure(s)
Online survey exploring determinants of age, gender, race, socioeconomic status, injury knowledge, attitudes, perceived social norms, and perceived behavioral control surrounding MSK injury disclosure, intention to disclose MSK injury, and actual behavior of disclosing MSK injury.

Results
Of the respondents, 457 (80.2%) reported having sustained ≥1 (mean = 3.2 ± 2.2; range = 1–10) MSK injuries related to sport. Those who endorsed having experienced an MSK injury disclosed not reporting or purposefully hiding 77% of their suspected MSK injuries. Several factors influenced a high intention to disclose MSK injury. Specifically, for each unit increase in total MSK injury knowledge (Exp[β] = 1.061, β=0.054, P = .020, 95% CI = 1.031, 1.221) and attitude (Exp[β] = 1.070, β = 0.064, P &lt; .001, 95% CI = 1.027, 1.115) score, 6% and 7% increases in the likelihood of a high intention to disclose an MSK injury, respectively, were observed. Moreover, for each unit increase in the social norm score (Exp[β] = 1.178, β=0.164, P &lt; .001, 95% CI = 1.119, 1.241), an 18% increase in the likelihood of a high intention to disclose an MSK injury was noted.

Conclusions
Designing interventions geared toward increasing the knowledge of signs and symptoms of MSK injury, improving attitudes surrounding disclosure, and better understanding the social context of disclosing MSK injuries may improve MSK injury disclosure behavior and reduce the associated social and economic burdens of these injuries.
Awareness of Use of GLP-1 agonists in the treatment of Diabetes Mellitus in Pakistan
Authors: Baig Muhammad Usman , Muhammad Ahmad Farooq  
Published: July 2023

Madam,
Diabetes mellitus (DM) is the most common metabolic disease worldwide. A quarter of Pakistan’s adult population is affected by DM. In Pakistan, the popular mono-therapy for treating both pre-diabetic and diabetic patients is metformin. For Metformin is combined with exogenous insulin/sitagliptin/sulphonylureas for dual therapy.1
Multiple studies over the past decade have shown encouraging results for GLP-1 analogues, especially semaglutide. The 2022 American Diabetic Association (ADA) and European Association for the Study of Diabetes (EASD) guidelines refer to semaglutide as a highly efficacious drug with minuscule side effects.2 They are the most efficacious drugs in reducing HBA1c among all the prescribed drugs for DM.3 In patients already taking metformin, the addition of subcutaneous semaglutide showed almost double the reduction in HBA1c than the addition of any other drug.3 In obese patients with DM, the weight reduction with semaglutide is significant than all other available medications, followed by its sister drug liraglutide.4 Recent studies also confirmed the added benefit of this class being cardioprotective and renoprotective, contrary to a belief once held about it.5 As of the studies done till now, the only majorly reported side effect of this drug is nausea and vomiting.
Internationally, physicians have started to widely prescribe this class of drug after their inclusion as the top recommended drug in ADA and EASD. We suggest that the physicians be educated on the mechanism of this drug in conferences and presentations. This will help raise awareness in the doctor’s community of Pakistan. This drug can prove fruitful in preventing the progression of DM to diabetic neuropathy and nephropathy, which can save countless lives and millions to our economy in pharmaceutical drugs.
Teacher Respons to Curriculum Changes in Madrasah Learning
Authors: Pelu Hanafi , Rosmiati Rosmiati 
Published: July 2023

This paper aims to explain the teachers’ reaction to curriculum changes in Madrasah learning. The qualitative research method will be applied in this study where researchers will describe data in the form of phrases rather than statistics. While descriptive research is commonly utilized by researchers. Descriptive types only explain phenomena, symptoms, events, and episodes that occur in certain populations or communities. According to the conclusions of this study, learning tools are the compass and forward and backward directions of educational institutions in Indonesia, particularly in Madrasas. Learning tools can be helpful in gaining success and success in implementing learning programs in certain educational units. Looking at the times, compiling a curriculum is not a simple task, but the curriculum is developed based on the needs for the development of a country's educational quality. Furthermore, the curriculum is a notion that must rise to meet all obstacles, yet changes to the curriculum cannot be avoided due to the necessity. Curriculum design is critical because education can meet the requirements of society. As a learning designer, the teacher must begin with a modest and concrete problem, such as the problem of the Madrasah environment. However, the teacher must also think broadly and be visionary. Teachers must remain professional in their tasks even when the curriculum in Indonesia changes, and they must provide a stimulating learning environment so that students feel challenged and like studying.
Meningkatkan Kinerja UMKM Melalui Pemasaran Digital untuk Meningkatkan Produk Perusahaan
Authors: Alexander Yayan Listanto 
Published: July 2023

Penelitian ini bertujuan untuk mengungkap beberapa strategi digital marketing dari produk baju bayi serta membuktikan efisiensi dari peningkatan kinerja UMKM melalui digital marketing. Penelitian ini menggunakan metode kualitatif deskriptif. Daya yang dinutuhkan sebagai pisau penelitian adalah data primer yang penulis peroleh dengan observasi dan wawancara kepada pihak yang berkaitan dengan penelitian ini. Dara sekunder penulis peroleh dari berbagai buku, artikel jurnal, dan litertur pendukung lainnya. Sementara hasil penelitian ini berupa: pertama, berdasarkan pendapat dari pemilik usaha UMKM yang meningkatakn kinerjanya melalui digital marketing hanya dengan membuat konten yang menarik dan mudah diingat orang. Kedua, berdasarkan pendapat dari peminat UMKM dan pelanggan “Garmen Baju Bayi Mamawawa” ini dapat mengefisiensi biaya dan dapat menjadi pesaing yang kuat untuk mereka yang tidak menggunakan digital marketing. Ketiga, berdasarkan pendapat masnyarakat umum ini UMKM memang membutuhkan peningkatan kerja dalam hal digital marketing untuk mengenalkan identitas produk dan identitas perusahaan UMKM di zaman yang serba menggunakan internet.
The Use of Web 2.0 Tools and Technologies in English Language Teaching-Learning Process
Authors: Roy Piu 
Published: July 2023

English language instruction increasingly makes use of web 2.0 tools and technologies as the most cutting-edge example of internet-based technology. Wikis, blogs, podcasts, social networks, and video conferencing are some of the most common examples of Web 2.0 technologies that have shown their use in language instruction and study. In the last ten years, Web 2.0 has become an essential part of the educational process, both within and outside the traditional classroom setting. Almost all language classes have used various technological tools and resources in recent years. Using multiple technologies has facilitated and improved students’ ability to learn new languages. The use of technology enables teachers to adapt classroom activities, which ultimately speeds up the language acquisition process. It is becoming more critical for teachers to use the tools and technology offered by Web 2.0 to encourage language learning in their classes. This research investigates the impact that contemporary technology has on the process of learning English as a second or foreign language. We looked at various mindsets to see what technology motivates English language learners to enhance their learning abilities. The researcher defines technology and explains how technology may be integrated into educational settings, namely language courses. It reviews previous studies on using Web 2.0 tools and technologies to enhance language learning abilities and makes recommendations for the improved use of these technologies, which aid students in improving their learning abilities. In addition, it reviews previous studies on using Web 2.0 tools and technologies to enhance language learning abilities. The anticipated results from the previously published research demonstrate that students’ language-learning abilities improve when they effectively use emerging technologies.
Organizational Commitment as an Antecedent of Organizational Citizenship Behavior: A Study of Nursing Staff Working in Select Government Hospitals in Sidama Regional State, Southern Ethiopia
Authors: Anisa Mengistu , Malhotra Meenakshi 
Published: July 2023

Successful organizations have employees who go beyond their formal job tasks and freely give their time and liveliness to succeed at the assigned job. Such humanity is neither prescribed nor required, yet it contributes to the smooth functioning of the organization. This study aimed to examine organizational commitment as an antecedent of Organizational Citizenship Behavior a study of nursing staff working in Select Government Hospitals in Sidama Regional State, Southern Ethiopia. Methodologically, the study has been mainly depending on the primary source of data obtained through nursing staff work in the Sidama regional state of southern Ethiopia. Among 1900 total nursing staff in the four hospitals in this study 210 samples have been considered for the analysis based on 204 of the respondents who responded to the questionnaire. In this study, SPSS and AMOS version 21 were applied for analysis purposes. The measurement model based on CFA reveals that the items are fitted for the construct after some of the items are removed as a result of low loadings. The structural equation model shows the positive relationship between the variables under the study. Based on the finding obtained theoretical and practical implications provided through the management of the hospitals need to have enhanced organizational commitment of nursing staff to reciprocate the result. Furthermore, the study opts for future researchers based on the gap mentioned.
Price Responses to Index Additions and Deletions: A Systematic Review with Bibliometric Analysis
Authors: Goyal Priyanka , Soni Pooja 
Published: July 2023

The present study aims to systematically review the research evidence available on the impact of additions and deletions of companies from various stock indices on their stock prices and provide directions for future research. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 flow diagram to select the final sample of 44 studies for systematic literature review using the Scopus database. These research studies have been reviewed subsequently to categorize, synthesize and map the extant literature using R studio. The study found that, on average, there is an increase in share prices of stocks being added to an index and stocks being excluded from the index evidenced negative abnormal returns. But the existing literature doesn’t provide conclusive evidence on whether these price effects are long or short-term. The study guides the investors, traders and other market participants regarding their long and short positions in the market and also provides future research directions to academicians.
Automation of Post-Order Costing Analysis By Using Visual Basic For Applications In Microsoft Excel: A Case Study
Authors: Kalwar Muhammad Ahmed , Khan Muhammad Ali , Wassan Asif Nawaz , Phul Zuhaib , Shaikh Shakeel Ahmed , Marri Hussain Bux 
Published: July 2023

Microsoft Excel is used to carry out reporting tasks in small and medium companies across the globe. Most people make reports manually in Microsoft Excel and the manual work takes a tremendous amount of time. The manual work can be easily automated with some effort in Microsoft Excel. This research is about the automation of report that was used to be made manually in Microsoft Excel.The present research is an extension of the previously conducted research (Kalwar, Shahzad, et al., 2022). The manual process to make the post-order costing analysis report in MS excel requires a lot of user time (22.80 minutes, just if there is a single order of only one article with one color), with the greater possibility of human error. Employees in ananonymous footwear company in Lahore used to generate the post-order costing report manually in Excel.Due to the above-mentioned reasons, it was proposedto automate the report using visual basic for applications (VBA) in Microsoft Excel.The planning and costing departmentof the company provided every single step required to make the report manually. A time study was conducted for each stepof report preparation using the stopwatch. VBA macros were programmed for automating all manual report-related processes in excel andthe accuracy of the report was also verified. After the report was automated, the time study was again conducted to measure the execution time after each click. A comparison of both methods indicated that the report automation saved 83.18% of employees' time Additionally, the automated method resulted in an error-free report, and the employee`sworkload was reducedas well.
Strength and conditioning programs in youth athletes: a systematic review
Authors: França Cíntia , Santos Francisco , Caldeira Romua ldo , Marques Adilson , Ihle Andreas , Lopes Helder , Gouveia Élvio Rúbio 
Published: July 2023

Purpose.The relationship between strength, power, and sports performance may have long-term effects on the development pathways of youth athletes. This study systematically reviewed the current evidence of strength and conditioning interventions among youngsters in competitive sports.Methods.The research was conducted following the Preferred Reporting Items for Systematic and Meta-Analyses (PRISMA) 2020 guidelines.Results.A total of 415 articles were identified, and 20 remained for analysis. All studies reported resistance training (RT) and/or plyometric training (PT) interventions as beneficial to improving youngsters’ overall physical fitness. The lower-body explosive strength, speed, and agility improvements were more evident in training plans that combined heavy RT and PT programs. The training frequency of twice a week was sufficient to induce strength gains. The results indicate that strength and conditioning programs positively influence sport-specific skills performance.Conclusions.PT and RT should not be implemented as single exercise interventions but as complementary programs to optimise physical and game performance. This study contributes to creating awareness among sports agents and coaches for integrating planned strength and conditioning programs with qualified instruction at least two times per week to improve young athletes’ physical development.