bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regorafenib plus Vincristine and Irinotecan in Pediatric Patients with Recurrent/Refractory Solid Tumors: An Innovative Therapy for Children with Cancer Study
Authors: Casanova Michela , Bautista Francisco , Campbell-Hewson Quentin , Makin Guy , Marshall Lynley V. , Verschuur Arnauld C. , Cañete Nieto Adela , Corradini Nadège , Ploeger Bart A. , Brennan Barbara J. , Mueller Udo , Zebger-Gong Hong , Chung John W. , Geoerger Birgit 
Published: August 2023

Abstract

Purpose:
This phase Ib study defined the safety, MTD, and recommended phase II dose (RP2D) of regorafenib combined with vincristine and irinotecan (VI). Secondary objectives were evaluation of antitumor activity and pharmacokinetics (PK) of regorafenib and irinotecan.

Patients and Methods:
Patients aged 6 months to &lt;18 years with relapsed/refractory solid malignancies [≥50% with rhabdomyosarcoma (RMS)] received regorafenib (starting dose 72 mg/m2/day) concomitantly or sequentially with vincristine 1.5 mg/m2 on days 1 and 8, and irinotecan 50 mg/m2 on days 1–5 (21-day cycle). Adverse events (AE) and tumor response were assessed. PK (regorafenib and irinotecan) were evaluated using a population PK model.

Results:
We enrolled 21 patients [median age, 10 years; 12, RMS; 5, Ewing sarcoma (EWS)]. The MTD/RP2D of regorafenib in the sequential schedule was 82 mg/m2. The concomitant dosing schedule was discontinued because of dose-limiting toxicities in 2 of 2 patients treated. Most common grade 3/4 (&gt;30% of patients) AEs were neutropenia, anemia, thrombocytopenia, and leukopenia. The overall response rate was 48% and disease control rate [complete response (CR)/partial response/stable disease/non-CR/non-progressive disease] was 86%. Median progression-free survival was 7.0 months [95% confidence interval (CI), 2.9–14.8] and median overall survival was 8.7 months (95% CI, 5.5–16.3). When combined with VI, regorafenib PK was similar to single-agent PK in children and adults (treated with regorafenib 160 mg/day).

Conclusions:
Regorafenib can be combined sequentially with standard dose VI in pediatric patients with relapsed/refractory solid tumors with appropriate dose modifications. Clinical activity was observed in patients with RMS and EWS (ClinicalTrials.gov NCT02085148).
Novel Tenzing 7 Delivery Catheter for Thrombectomy in Acute Stroke: A Clinical Multicenter Experience
Authors: Tonetti Daniel A. , Bhattacharyya Meghna , Koneru Manisha , English Joey , Settecase Fabio , Kim Warren , Patel Pratit , Thomas Ajith , Jovin Tudor , Hanel Ricardo , Benalia Victor H.C. , Cortez Gustavo M. , Aghaebrahim Amin , Sauvageau Eric , Abdalkader Mohamad , Nguyen Thanh N. , Klein Piers , Dmytriw Adam , Shaikh Hamza A. 
Published: August 2023

Background
Preliminary in vitro and early clinical experience of the Tenzing 7 delivery catheter demonstrated high success rates of aspiration catheter intracranial delivery with minimal complications. This study aimed to examine the efficacy, safety, and efficiency of the Tenzing 7 delivery catheter to deliver therapeutic devices in aspiration mechanical thrombectomy for acute ischemic strokes using clinical experience from multiple institutions.

Methods
We performed a retrospective analysis of prospectively collected data from patients with acute ischemic stroke treated with aspiration mechanical thrombectomy using the Tenzing 7 delivery catheter between January 2020 and July 2022 at 6 high volume stroke centers. Primary efficacy outcome was success in aspiration catheter delivery to the face of the thrombus, and primary safety end point was rate of procedural complication.

Results
Of a total of 176 patients (mean age 70.1±14.9 years, 56.3% female, 89.2% middle cerebral artery occlusions), first‐pass effect (modified Thrombolysis in Cerebral Infarction score≥2B) was achieved in 90/166 (54.2%) successfully revascularized patients. Tenzing 7 delivered the aspiration catheter of choice to the site of occlusion in 95.9% of cases; the clot was not crossed with Tenzing 7 in 69% of cases. Successful recanalization (modified Thrombolysis in Cerebral Infarction score≥2B) was achieved in 94.9% of cases requiring a median of 1 pass (interquartile range 1–3). Nonflow limiting vessel dissection unrelated to Tenzing 7 occurred in 4 patients (2.3%), and intracranial vessel perforation unrelated to Tenzing 7 occurred in 4 cases (2.3%).

Conclusion
This multicenter clinical experience using Tenzing 7 in mechanical thrombectomy demonstrated high rates of technical success and a modest complication rate, similar to the published rates of technical success with other thrombectomy techniques. The Tenzing 7 delivery catheter is effective and safe for the delivery of the aspiration catheter in patients undergoing thrombectomy for acute ischemic stroke.
Defensive behaviour plasticity in Ananteris mauryi Lourenço, 1982 (Scorpiones: Buthidae) facing different predator species
Authors: Silva-Júnior André O. , Barbosa-da-Silva Hugo R. , Salomão Renato P. , Moura Geraldo J.B. , Lira André F.A. 
Published: August 2023

Abstract
Small species often fall prey to a wide range of predators in their natural habitats, and therefore require behavioural strategies to mitigate predation rates. In this study, we investigated the defensive behaviour of Ananteris mauryi, a small-bodied scorpion, against different natural predator species. Behavioural trials were conducted with A. mauryi individuals facing two different predators, spider and scorpion. Our results show that A. mauryi altered their defensive acts depending on the predator type, swinging their telson, cleaning their pedipalps, and run more frequently when facing spiders than scorpions. Additionally, we observed variation in the duration of behaviours according to predator type, with stinging attempts being performed more frequently against scorpions and run and metasoma swinging against spiders. Our findings suggest that scorpions have the ability to modulate their defensive behaviour according to the type of predator they face.
Environmental Autonomy
Authors: Savaşan Zerrin 
Published: August 2023

Abstract
This article aims to get a new brand start to the autonomy debate by examining environmental autonomy (ea) as a new concept under international law (il). In this respect, firstly, it focuses on establishing why such a notion is needed, where the idea comes from, so, on which basis the article’s analysis has been built. Secondly, to conceptualise ea in legal terms, it makes research on two sub-debates involving the principle of self-determination and nonhuman rights approach. Finally, it concludes that although there is no tangible certain legal basis to apply such a concept under current il other than the terms of indigenous rights; developments in recent decades show that, ea debate, testing the boundaries of law, might truly have the potential to the development of literature beyond the anthropocentric paradigms; but also underlines the need for further work on its potential legal framework under il.
“A Native of Poland Professing the Arts in London”: The Unconventional Jewish Life and Thought of Solomon Yom Tov Bennett (1767–1838)
Authors: Ruderman David 
Published: August 2023

Abstract
This essay offers a new reconstruction of the fascinating life and works of Solomon Yom Tov Bennett (1767–1838), a Jewish engraver and biblical scholar who emigrated from Belarus via Copenhagen and Berlin to London. While Bennett’s intellectual path might appear similar to several other notable Polish Jewish immigrants to Western Europe, he is quite distinctive for his remarkable coadunation of art and thought, for his unusual focus on biblical studies, for opening social and intellectual connections with some of the most famous and accomplished Christian intellectuals of London, and for his self-determination and drive to complete his life-long ambition of serving Western civilization by rewriting and correcting the entire standard edition of the English Old Testament, a task of translation, he fervently believed, that could only be fulfilled by a learned Jewish Hebraist like himself.
The Apprenticeship System in the Caribbean
Authors: Heuman Gad 
Published: August 2023

Abstract
Slavery was abolished in the Anglophone Caribbean on August 1, 1834. On that date, the enslaved became legally free. However, the freedom of the enslaved was heavily circumscribed by the Apprenticeship system which followed immediately after August 1. Under the terms of this system, former slaves—now called apprentices—were required to work up to 45 hours per week for their former masters without compensation. Apprentices resisted the system at its outset; subsequently, they attempted to assert their rights as much as possible during the Apprenticeship period, even in the face of a highly oppressive system. Yet, like the enslaved, apprentices have left very little direct evidence in the form of letters or diaries. But because of their appearances before the stipendiary magistrates and in the reports generated about the Apprenticeship system, we can recreate aspects of their world and understand how apprentices sought to take advantage of Apprenticeship for their own benefit.
The McKenzie Method versus guideline-based advice in the treatment of sciatica: 24-month outcomes of a randomised clinical trial
Authors: Kilpikoski Sinikka , Häkkinen Arja H , Repo Jussi P , Kyrölä Kati , Multanen Juhani , Kankaanpää Markku , Vainionpää Aki , Takala Esa-Pekka , Kautiainen Hannu , Ylinen Jari 
Published: August 2023

Objective To compare the effectiveness of a McKenzie Method intervention in patients with sciatica with guideline-based patient education. Design Multi-centre, assessor-blinded, parallel-group, randomised trial Setting Two tertiary hospitals providing operative spinal care. Subjects Sciatica patients with magnetic resonance imaging-confirmed lumbar disc herniation compressing a nerve root. Interventions The McKenzie group received specific back exercises for seven visits combined with an educational book, and the Control group received a single session of self-management guidance according to usual practices. Main measures The primary outcome was the number of surgical operations. Secondary outcomes were pain measured using the Visual Analogue Scale, disability using the Oswestry Disability Index and health-related quality of life using a RAND-36 questionnaire at baseline and 24-month follow-up. Results Altogether 66 patients, mean age of 43 years, of which 50% were females with long-lasting sciatica, mean 16 weeks, were randomised to two groups. Nineteen patients (29%) had surgery. There was no significant difference in surgery rates between the groups. Back and leg pain decreased, and disability improved in both groups. Health-related quality of life improved in six dimensions out of eight in both groups. There were no significant between-group changes in the patient-reported outcomes at the follow-up. Conclusions Multiple sessions of McKenzie-based back exercises with a McKenzie-specific patient's educational book produced effects equal to guideline-based advice at long-term follow-up. However, the power of these results is diminished due to the small patient population and confounding factors.
Factors Associated with Transition to Serious Mental Illness: Facteurs associés à la transition à une maladie mentale grave
Authors: Jalali Sara , Liu Lu , Wang JianLi , Kennedy Sidney H. , MacQueen Glenda , Lebel Catherine , Goldstein Benjamin l. , Bray Signe , Addington Jean 
Published: August 2023

Objective There is increasing interest in early intervention and detection strategies for youth at-risk of developing a serious mental illness (SMI). Little is known about early factors that may be related to the later development of a SMI; thus, the aim of this study was to determine what clinical factors might relate to the development of in this study psychosis, bipolar disorder and severe or recurrent major depression in at-risk youth. Method The sample consisted of 162 youth aged 12–26 years at different stages of risk. Thirty-one participants developed a SMI during the study. Those who made a transition were compared on a range of baseline clinical and functional measures with those who did not make the transition. A Cox regression model was used to assess the association between measures and later development of a SMI. Results Female sex, attenuated psychotic symptoms as assessed with the Scale of Psychosis-Risk Symptoms (SOPS) and ratings on the K-10 Distress Scale, were found to be significantly associated with the later transition to mental illness. Females were 2.77 times more likely to transition compared to males. For the SOPS and K-10 scales, there is a 14% increase in the transition rate relative to a one-scale increase in SOPS and a 7% increase in the transition rate relative to a one-point increase in the K-10. Conclusions Results from these longitudinal data provide further insight into the specific clinical measures that may be pertinent in early detection of mental illnesses.
‘Most people have no idea what autism is’: Unpacking autism disclosure using social media analysis
Authors: Edwards Chris , Love Abigail M A , Jones Sandra C , Cai Ru Ying , Nguyen Boyd Thai Hoang , Gibbs Vicki 
Published: August 2023

Autism disclosure can be a complicated decision that autistic people experience. Positive outcomes can include feelings of acceptance and support, but negative outcomes can include stigma and discrimination. Although a surge in research on this topic has led to more understanding around autism disclosure, the methodologies used may have limited who was contributing to the conversation and data. To overcome this, we analyzed 3 years (2020−2022) of social media data (Reddit and Twitter) as this was public information that did not rely on researcher data collection. Reflexive thematic analysis of 3121 posts led to the generation of four themes: People do not understand autism (with experiences related to employment, dating, healthcare and mental health), autistic people just want privacy and respect, autistic people can lead us forward and non-autistic people need to assume more responsibility. We discuss how autistic adults experience the impact of society’s lack of understanding of autism on a daily basis whether they disclose or not, and that it is everybody’s responsibility to challenge negative stereotypes and promote a more inclusive society. Lay abstract Autism disclosure – that is sharing their autism diagnosis or identity with a person or people – is a difficult decision for many autistic people. While telling people they are autistic can be positive and helpful, it can also create a lot of problems. What we have learnt is that disclosure is really complicated. Rather than asking research participants questions about what might happen, we looked at what people were saying on public social media posts (Reddit and Twitter) about what did happen. We used three years of posts that were related to autism disclosure from a wide range of adults (autistic and non-autistic). Four main ideas were created from our data, with the key finding being that society does not understand autism. This lack of understanding creates problems for autistic people in work, dating, healthcare and mental health. The remaining ideas were that autistic people should have privacy and be treated with respect, that autistic representation can help society and that non-autistic people need to do more to help autistic people. Our findings support that society needs to do more through autism advocacy, better media representation and more public role models. Increasing the accuracy of understanding of autism across society will mean that autistic people can feel safer to disclose if they want to.
Ten-year experience with use of cryopreserved allografts for redo infrapopliteal bypass
Authors: Mastrorilli Davide , Mezzetto Luca , Piffaretti Gabriele , D’Oria Mario , Bruno Salvatore , Franchin Marco , Veraldi Gian F 
Published: August 2023

Introduction The aim of this study is to report the early and late outcomes of cryopreserved saphenous vein (CSV) in redo infrainguinal bypass and to investigate possible predictors of primary patency loss. Methods All patients who underwent a redo bypass for critical limb ischemia from January 2010 to December 2020 were reviewed. Early and late complications were analyzed and included. The endpoints of the study were all cause mortality, major limb amputation, and primary patency (PP). Results Data were collected from 95 patients. Among the entire cohort, 16 (16.8%) patients received a cryopreserved vessel bypass with anastomosis in the popliteal artery and 79 (83.2%) patients had cryopreserved vessel bypasses with distal anastomosis in tibial vessels. Median duration of follow-up was 73 months; during this, period estimated survival at 5 years was 80.5 ± 4% (95% CI, 78.0–91.2) and estimates of freedom from limb amputation was 90.3 ± 3.2% (95% CI, 87.3–98.1). Overall, the estimated primary patency of the bypass was 43.7 ± 6.7% (95% CI, 30.2–51.4). On multivariable analysis, intraprocedural tibial vessel angioplasty (HR = 2.3, p = 0.01), distal anastomosis in tibial vessels (HR = 3.6, p = 0.36), and the use of a composite graft (HR = 2.4, p = 0.01) were independently associated with loss of PP. Conclusions The use of CSV in redo bypass is an effective strategy in salvaging threatened lower extremities and in preventing or delaying limb amputation. Our results confirm that further attempts at revascularization are generally appropriate, even in technically changing patients.
Applications of drug delivery systems, organic, and inorganic nanomaterials in wound healing
Authors: Lo Samantha , Mahmoudi Ebrahim , Fauzi Mh Busra 
Published: August 2023

AbstractThe skin is known to be the largest organ in the human body, while also being exposed to environmental elements. This indicates that skin is highly susceptible to physical infliction, as well as damage resulting from medical conditions such as obesity and diabetes. The wound management costs in hospitals and clinics are expected to rise globally over the coming years, which provides pressure for more wound healing aids readily available in the market. Recently, nanomaterials have been gaining traction for their potential applications in various fields, including wound healing. Here, we discuss various inorganic nanoparticles such as silver, titanium dioxide, copper oxide, cerium oxide, MXenes, PLGA, PEG, and silica nanoparticles with their respective roles in improving wound healing progression. In addition, organic nanomaterials for wound healing such as collagen, chitosan, curcumin, dendrimers, graphene and its derivative graphene oxide were also further discussed. Various forms of nanoparticle drug delivery systems like nanohydrogels, nanoliposomes, nanofilms, and nanoemulsions were discussed in their function to deliver therapeutic agents to wound sites in a controlled manner.
Intelligence, motoric and psychological outcomes in children from different ART treatments: a systematic review and meta-analysis
Authors: Djuwantono Tono , Aviani Jenifer Kiem , Permadi Wiryawan , Halim Danny , Achmad Tri Hanggono , Dhamayanti Meita 
Published: August 2023

Abstract
Background
Subtle abnormalities in children’s intelligence, motor skills, and psychology from various assisted reproductive treatments (ARTs) might be underdiagnosed. Understanding the prognosis of intelligence, motor skills, and psychology in children from ART would provide parents with reasonable expectations and enable them to plan relevant support to achieve the optimum potential in ART children.

Methods
We searched PubMed, EMBASE, Ovid, Google Scholar, and Scopus databases until April 13, 2021, to identify relevant studies. Thirty-four studies met the inclusion and exclusion criteria. The meta-analysis employed a standardized mean difference model. The outcome of this study is to compare intelligence quotient (IQ), motoric ability, and behavioral problems between all ARTs, in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) to naturally conceived (NC) children. Subdomains of intelligence based on the Cattell, Horn, and Carroll Model (CHC Model) of cognitive architecture, including fluid reasoning, short-term and working memory, processing speed, visual-spatial ability, long-term memory retrieval, and crystalized intelligence (knowledge), were evaluated and summarized in details. Motor skill was stratified into two domains: gross motoric and fine motoric. Behavioral problem was categorized as externalizing and internalizing behavior.

Results
Meta-analysis showed that verbal intelligence score in IVF toddlers is significantly lower than NC toddlers (p = 0.02); conversely, ICSI toddlers scored significantly higher verbal intelligence score compared to NC toddlers (p = 0.005). Toddlers born after ART had significantly lower non-verbal intelligence score (p = 0.047). IVF toddlers scored significantly lower fine motor score (p = 0.01) compared to naturally conceived toddlers. Based on parent's CBCL, NC toddlers had higher total (p = 0.01) and externalizing behavior (p = 0.001) scores compared to ART toddlers. Evaluation of full scale IQ and all domains of intelligence in preschool and primary school children revealed that no significant differences exist between ART and NC children. Based on preschool and primary school parents' CBCL, IVF children had significantly lower externalizing behavior score compared to NC children (p = 0.04). Meta-analyses of studies on young adolescents revealed that ART young adolescents scored higher academically than their NC counterparts, including on mathematics (p < 0.00001) and reading or language (p < 0.00001).

Conclusions
Despite differences in certain aspects, this finding suggests that ART is unlikely to cause negative impacts on children’s neurodevelopment.
Aberrant oscillatory activity in neurofibromatosis type 1: an EEG study of resting state and working memory
Authors: Booth Samantha J. , Garg Shruti , Brown Laura J. E. , Green Jonathan , Pobric Gorana , Taylor Jason R. 
Published: August 2023

AbstractBackgroundNeurofibromatosis type 1 (NF1) is a genetic neurodevelopmental disorder commonly associated with impaired cognitive function. Despite the well-explored functional roles of neural oscillations in neurotypical populations, only a limited number of studies have investigated oscillatory activity in the NF1 population.MethodsWe compared oscillatory spectral power and theta phase coherence in a paediatric sample with NF1 (N = 16; mean age: 13.03 years; female:n = 7) to an age/sex-matched typically developing control group (N = 16; mean age: 13.34 years; female:n = 7) using electroencephalography measured during rest and during working memory task performance.ResultsRelative to typically developing children, the NF1 group displayed higher resting state slow wave power and a lower peak alpha frequency. Moreover, higher theta power and frontoparietal theta phase coherence were observed in the NF1 group during working memory task performance, but these differences disappeared when controlling for baseline (resting state) activity.ConclusionsOverall, results suggest that NF1 is characterised by aberrant resting state oscillatory activity that may contribute towards the cognitive impairments experienced in this population.Trial registrationClinicalTrials.gov, NCT03310996 (first posted: October 16, 2017).