bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the importance of species and their assemblages for the biodiversity‐ecosystem multifunctionality relationship
Authors: Mori Akira S. , Isbell Forest , Cadotte Marc W. 
Published: May 2023

AbstractBiodiversity changes, such as decline in species richness and biotic homogenization, can have grave consequences for ecosystem functionality. Careful investigation of biodiversity–ecosystem multifunctionality linkages with due consideration of conceptual and technical challenges is required to make the knowledge practically useful in managing social–ecological systems. In this paper, we introduced different methods to assess perspectives regarding the issue of diversity‐multifunctionality, including a possible multifunctional redundancy/uniqueness, and the influences of the number and identity of functions on multifunctionality. In particular, we aimed to align methods with detecting the mechanisms underpinning diversity‐multifunctional relationships that are free from statistical biases. Based on a set of novel methods that excluded analytical biases resulting from differences in the number and identities of multiple functions considered, we found that a substantial portion of species disproportionately supported ecosystem functions and that the diversity effects on multifunctionality were more markedly observed when more functions were considered. These results jointly emphasize that individual species are, to some extent, both functionally unique as well as redundant, highlighting the complexity and necessity for managed assemblages to retain high levels of diversity. We also observed that the relative magnitude of uniqueness or redundancy can differ between species and functions and therefore should be defined in a multifunctional context. We further found that only a small subset of species was identified as significantly less important, especially at low levels of multifunctionality. Taken together, given the low level of multifunctional redundancy we identified, we stress that unraveling the hierarchical roles of biodiversity at different levels, such as individual species and their assemblages, should be a high research priority, in both theory and practice.
Facile Fabrication of Bi24O31Br10 Nanosheets with Phosphorus Sulfide Quantum Dots for Highly Photocatalytic Treating Organic Dyes
Authors: Cao Congli , Xu Hu , Wang Dongsheng , Fang Zhen , Yu Jun , Wang Yuhong 
Published: May 2023

AbstractHerein, we report the synthesis of novel narrow band gap phosphorus sulfide quantum dots (PSQDs)‐modified bismuth oxybromide (Bi24O31Br10) heterojunction (noted as BOB/PS) for the highly efficient photo‐degradation of hazardous organic pollutants including rhodamine B (RhB), methyl orange (MO), and malachite green (MG). Such a high photocatalytic activity of BOB/PSQDs heterojunction derives from the improved visible‐light response capacity, high surface area/pore volume, and suitable band structure for efficient electron transfer to generate reactive oxygen species (ROS). ROS trapping experiments demonstrate that hydroxy (⋅OH) and superoxide radicals (⋅O2−) play important roles in the photo‐degradation. A possible S‐scheme mechanism for the enhanced photocatalytic activity of BOB/PS is proposed.
Fluorinated Analogues to the Pentuloses of the Pentose Phosphate Pathway
Authors: Scheibelberger Lukas , Stankovic Toda , Liepert Kaja , Kienzle Andreas , Patronas Eva‐Maria , Balber Theresa , Mitterhauser Markus , Haschemi Arvand , Pallitsch Katharina 
Published: May 2023

AbstractFluorinated carbohydrates are valuable tools for enzymological studies due to their increased metabolic stability compared to their non‐fluorinated analogues. Replacing different hydroxyl groups within the same monosaccharide by fluorine allows to influence a wide range of sugar–receptor interactions and enzymatic transformations. In the past, this principle was frequently used to study the metabolism of highly abundant carbohydrates, while the metabolic fate of rare sugars is still poorly studied. Rare sugars, however, are key intermediates of many metabolic routes, such as the pentose phosphate pathway (PPP). Here we present the design and purely chemical synthesis of a set of three deoxyfluorinated analogues of the rare sugars d‐xylulose and d‐ribulose: 1‐deoxy‐1‐fluoro‐d‐ribulose (1DFRu), 3‐deoxy‐3‐fluoro‐d‐ribulose (3DFRu) and 3‐deoxy‐3‐fluoro‐d‐xylulose (3DFXu). Together with a designed set of potential late‐stage radio‐fluorination precursors, they have the potential to become useful tools for studies on the complex equilibria of the non‐oxidative PPP.
Y‐box binding protein 1 influences zygotic genome activation by regulating N6‐methyladenosine in porcine embryos
Authors: Jiang Wen‐Jie , Sun Ming‐Hong , Li Xiao‐Han , Lee Song‐Hee , Heo Geun , Zhou Dongjie , Cui Xiang‐Shun 
Published: May 2023

AbstractY‐box binding protein 1 (YBX1) is a member of the family of DNA‐ and RNA‐binding proteins that play crucial roles in multiple aspects, including RNA stabilization, translational repression, and transcriptional regulation; however, its roles in embryo development remain less known. In this study, to investigate the function of YBX1 and its mechanism of action in porcine embryo development, YBX1 was knocked down by microinjecting YBX1 siRNA at the one‐cell stage. YBX1 is located in the cytoplasm during embryonic development. The mRNA level of YBX1 was increased from the four‐cell stage to the blastocyst stage but was significantly decreased in YBX1 knockdown embryos compared with the control. Moreover, the percentage of blastocysts was decreased following YBX1 knockdown compared with the control. Defecting YBX1 expression increased maternal gene mRNA expression and decreased zygotic genome activation (ZGA) gene mRNA expression and histone modification owing to decreased levels of N6‐methyladenosine (m6A) writer N6‐adenosine‐methyltransferase 70 kDa subunit (METTL3) and reader insulin‐like growth factor 2 mRNA‐binding protein (IGF2BP1). In addition, IGF2BP1 knockdown showed that YBX1 regulated the ZGA process through m6A modification. In conclusion, YBX1 is essential for early embryo development because it regulates the ZGA process.
Working hard for money decreases risk tolerance
Authors: Bechler Christopher J. , Lutfeali Samina , Huang Szu‐chi , Morris Joshua I. 
Published: May 2023

AbstractThis research examines how the effort that consumers exert to earn money affects their risk tolerance. We theorize and find that working harder—that is, more effortful earning—increases perceived ownership and valuation of earnings, and thus aversion to losing them, resulting in lower risk tolerance, even when risk is associated with better expected outcomes. Documenting this causal negative effort–risk relationship is important because it (1) runs contrary to consumers' lay beliefs and population‐level analysis which conversely suggest a positive effort–risk correlation (i.e., a Simpson's paradox, Experiment 2), (2) expands understanding of how the way in which people acquire money affects risk tolerance beyond classic research on windfall gains (i.e., unanticipated rewards) and house money (i.e., unrealized gains), and hence (3) reveals a unique mechanism of perceived ownership that drives this negative causal relationship. Leveraging this unique mechanism, we further show that this negative effort–risk relationship can be attenuated by changing the currency of the money that consumers earn to be one that consumers have low ownership over (e.g., Bitcoin for non‐crypto users).
2023 HRS/EHRA/APHRS/LAHRS Expert Consensus Statement on Practical Management of the Remote Device Clinic
Authors: Ferrick Aileen M. , Raj Satish R. , Deneke Thomas , Kojodjojo Pipin , Lopez‐Cabanillas Nestor , Abe Haruhiko , Boveda Serge , Chew Derek S. , Choi Jong‐Il , Dagres Nikolaos , Dalal Aarti S. , Dechert Brynn E. , Frazier‐Mills Camille G. , Gilbert Olivia , Han Janet K. , Hewit Sherri , Kneeland Christine , Mirza Starr DeEllen , Mittal Suneet , Ricci Renato Pietro , Runte Mary , Sinclair Susan , Alkmim‐Teixeira Ricardo , Vandenberk Bert , Varma Niraj ,   Document Reviewers, Davenport Elizabeth , Freedenberg Vicki , Glotzer Taya V. , Huang Jin‐Long , Ikeda Takanori , Kramer Daniel B. , Lin David , Rojel‐Martínez Ulises , Stühlinger Markus , Varosy Paul D. 
Published: May 2023

AbstractRemote monitoring is beneficial for the management of patients with cardiovascular implantable electronic devices by impacting morbidity and mortality. With increasing numbers of patients using remote monitoring, keeping up with higher volume of remote monitoring transmissions creates challenges for device clinic staff. This international multidisciplinary document is intended to guide cardiac electrophysiologists, allied professionals, and hospital administrators in managing remote monitoring clinics. This includes guidance for remote monitoring clinic staffing, appropriate clinic workflows, patient education, and alert management. This expert consensus statement also addresses other topics such as communication of transmission results, use of third‐party resources, manufacturer responsibilities, and programming concerns. The goal is to provide evidence‐based recommendations impacting all aspects of remote monitoring services. Gaps in current knowledge and guidance for future research directions are also identified.
Discovery of novel serum biomarkers for diagnosing and predicting postmenopausal osteoporosis patients by 4D‐label free protein omics
Authors: Li Chunyan , Pan Haizhou , Liu Wei , Jin Guohong , Liu Wuzheng , Liang Cuiying , Jiang Xieyuan 
Published: May 2023

AbstractWe aimed to identify protein biomarkers that could rapidly and accurately diagnose osteoporosis patients (OPs) using a highly sensitive proteomic immunoassay. Four‐dimensional (4D) label‐free proteomics analysis was performed to determine the differentially expressed proteins in serum collected from 10 postmenopausal osteoporosis patients and 6 non‐osteoporosis patients. The ELISA method was used to select the predicted proteins for verification. Serum was taken from 36 postmenopausal osteoporosis patients and 36 healthy individuals from normal postmenopausal women. Receiver operating characteristic (ROC) curves were used to determine the diagnostic potential of this method. We validated the expression of these six proteins using ELISA. The CDH1, IGFBP2, and VWF of osteoporosis patients were significantly higher than those of the normal group. PNP was significantly lower than that in the normal group. And using ROC curve calculation, serum CDH1 had a cut‐off of 3.78 ng/mL with a sensitivity of 84.4%, and PNP had a cut‐off of 944.32 ng/mL with 88.9% sensitivity. These outcomes suggest that serum‐level CHD1 and PNP have the potential power as effective indicators for the diagnosis of PMOP. Our results suggest that CHD1 and PNP might be associated with the pathogenesis of OP and would be helpful in diagnosing OP. Therefore, CHD1 and PNP may act as potential key markers in OP.
Assessment of cyanide intake through consumption of cassava‐based diets in the Democratic Republic of Congo
Authors: Miderho Christus C. , Njue Lucy G. , Abong' George O. 
Published: May 2023

AbstractBackgroundKonzo is attributed to inadequate cassava processing and consumption of cassava meals with little protein, which is characterized by a neurological disorder that causes paralysis of the lower limbs. However, the exposure to cyanide in the Mwana health zone is still unknown while the prevalence of konzo is assumed to be high compared with other areas in the Democratic Republic of Congo (DRC).ResultsThe results showed that women are the most affected (56.7%), followed by young people under the age of 10 (27%), and people from low socioeconomic class at 93.4%. The prevalence of konzo in Burhinyi is 0.06%. Cyanide intake by the population of Burhinyi ranged from 26 to 271 mg/kg bw/day at the 95th percentile through consumption of cassava‐based ugali. Margin of exposure was around 0.271 and 0.393 g/person/day.ConclusionPoor people, women, and children are more at risk for konzo disease due to a diet dominated by under processed food made from cassava. However, since 2011, the study area's konzo prevalence has remained constant.
Synchrony in psychotherapy: High physiological positive concordance predicts symptom reduction and negative concordance predicts symptom aggravation
Authors: Gernert Clara C. , Nelson Afton , Falkai Peter , Falter‐Wagner Christine M. 
Published: May 2023

AbstractObjectiveTherapeutic alliance is often considered as a predictor for therapeutic success. This study explored dyadic synchrony of skin conductance response (SCR) during naturalistic therapeutic interactions and investigated its potential as an objective biomarker for predicting therapy effectiveness.MethodsIn this proof‐of‐concept study, skin conductance from both dyad members was continuously measured via wristbands during psychotherapy. Patients and therapists completed post‐session reports capturing their subjective appraisal of therapeutic alliance. Additionally, patients completed symptom questionnaires. Each therapeutic dyad was recorded twice in a follow‐up design. The first session of the follow‐up group was assessed for physiological synchrony (Single Session Index (SSI)). Therapy outcome was captured by the difference between symptom severity scores over time.ResultsSCR synchrony significantly predicted the outcome variable of change in patients' global severity index (GSI). High positive SCR concordance was linked to a reduction in patients' GSI, while negative or small positive SSI values were linked to an increase in patients' GSI.ConclusionThe results demonstrate the presence of SCR synchrony in clinical interactions. Skin conductance response synchrony was a significant predictor for change in patients' symptom severity index, emphasizing its potential as an objective biomarker in the context of evidence‐based psychotherapy.
What affects self‐regulated learning ability in undergraduate nursing students: A structural equation modelling approach
Authors: Zhang Hongchen , Xiong Huajun , Chung Loretta Yuet Foon , Wang Yanhong , Wang Peiling , Fang Lei , Han Lin , Yang Yanwei 
Published: May 2023

AbstractAimTo examine how the effects of hardiness, self‐efficacy and positive academic emotion related to the SRL ability of undergraduate nursing students.DesignA cross‐sectional survey was designed.MethodsA total of 395 Chinese undergraduate nursing students from two undergraduate colleges filled out the questionnaires from May to June 2019. The relationships between hardiness, self‐efficacy, positive academic emotion and SRL ability were analysed by structural equation modelling.ResultsThe response rate was 94.05%. SRL ability was significantly positive correlated with hardiness, self‐efficacy and positive academic emotion in undergraduate nursing students. Self‐efficacy (β = 0.417, p < 0.001) and positive academic emotion (β = 0.232, p < 0.001) showed a direct effect on the SRL ability. Although hardiness showed no direct effect on the SRL ability, it affected SRL ability through three indirect ways: self‐efficacy (77.778%), positive academic emotion (14.184%) and the chain mediating effect from self‐efficacy to positive academic emotion (8.038%).ConclusionsNursing students with a higher level of hardiness would have higher self‐efficacy, and more positive and stable academic emotions to obtain the better SRL ability. The produced model provides insights into several factors associated with SRL ability of nursing students. Hardiness, self‐efficacy and positive academic emotion should be emphasized in the education of nursing students because these factors could improve their SRL ability and promote their life‐long learning.
Association of two variable number of tandem repeats in the monoamine oxidase A gene promoter with suicide completion: The present study and meta‐analysis
Authors: Hasegawa Masashi , Tanifuji Takaki , Okazaki Satoshi , Otsuka Ikuo , Shirai Toshiyuki , Shindo Ryota , Horai Tadasu , Mouri Kentaro , Takahashi Motonori , Kondo Takeshi , Ueno Yasuhiro , Hishimoto Akitoyo 
Published: May 2023

AbstractBackgroundOne potential cause of suicide is serotonergic dysfunction. Sex differences have been reported to modulate the effects of serotonergic polymorphisms. Monoamine oxidase A (MAOA) is an enzyme that degrades serotonin and is located on the X chromosome. A previous study indicated that the upstream (u) variable number of tandem repeat (VNTR) in the MAOA gene promoter may be associated with suicide. However, a meta‐analysis showed that this polymorphism may not be related to suicide. According to a recent study, compared with the uVNTR, the distal (d)VNTR and the haplotypes of the two VNTRs modulate MAOA expression.MethodsWe examined the two VNTRs in the MAOA gene promoter in 1007 subjects who committed suicide and 844 healthy controls. We analyzed the two VNTRs using fluorescence‐based polymerase chain reaction assays. We conducted a meta‐analysis for the two VNTRs to update it.ResultsOur results demonstrated that neither the genotype‐based associations nor allele/haplotype frequencies of the two VNTRs were significantly associated with suicide. In the meta‐analysis, we did not indicate relationships between uVNTR and suicide nor did we identify articles analyzing dVNTR in suicide.ConclusionOverall, we did not find a relationship between the two VNTRs in the MAOA promoter and suicide completion; thus, warranting further studies are required.
Targeting peroxisome proliferator‐activated receptor γ proteasomal degradation by magnolol is a potential avenue for adipogenesis‐mediated metabolic homeostasis
Authors: Li Peng‐Long , Li Mei , Wang Zhenya , Wang Xiao‐Ming , Liu Shuai‐Yang , Tian Song , Wang Zhou‐Xiang , Cheng Xu , Hu Yufeng , Zhang Peng , She Zhi‐Gang , Yang Hailong , Li Hongliang , Zhang Xiao‐Jing 
Published: May 2023

AbstractObjectiveAdipogenesis has been recognized as an attractive avenue for maintaining systemic homeostasis, with peroxisome proliferator‐activated receptor γ (PPARγ) showing predominant roles in this process. This study aims to identify promising drug candidates by targeting PPARγ for adipogenesis‐based metabolic homeostasis and to clarify the detailed mechanisms.MethodsMolecular events contributing to adipogenesis were screened, which identified PPARγ as having the predominant role. Promising agents of adipogenesis agonism were screened using a PPARγ‐based luciferase reporter assay. The functional capacity and molecular mechanisms of magnolol were intensively examined using 3T3‐L1 preadipocytes and dietary models.ResultsThis study found that F‐box only protein 9 (FBXO9)‐mediated lysine 11 (K11)‐linked ubiquitination and proteasomal degradation of PPARγ are critically required during adipogenesis and systemic homeostasis. Notably, magnolol was identified as a potent adipogenesis activator by stabilizing PPARγ. The pharmacological mechanisms investigations clarified that magnolol directly binds to PPARγ and markedly interrupts its interaction with FBXO9, leading to a decline in K11‐linked ubiquitination and proteasomal degradation of PPARγ. Clinically important, magnolol treatment significantly facilitates adipogenesis in vitro and in vivo.ConclusionsThe downregulation of K11‐linked ubiquitination of PPARγ caused by FBOX9 is essentially required for adipogenesis, while targeting PPARγ‐FBXO9 interaction provides a new avenue for the therapy of adipogenesis‐related metabolic disorder.
Betaine–homocysteine methyltransferase promotes adipocyte commitment and insulin resistance via p38 MAPK/Smad signaling
Authors: Liu Chuchu , Zhang Yao , Wang Yanping , Wang Ning , Xu Junting , Liang Xingxing , Xiong Jie , Lu Sijia , Zhou Peihui , Liu Junli , Chen Suzhen 
Published: May 2023

AbstractObjectiveBetaine–homocysteine methyltransferase (Bhmt) belongs to the family of methyltransferases and is involved in the one‐carbon metabolic cycle, which is associated with the risk of diabetes and adiposity. This study aimed to explore whether Bhmt participated in the development of obesity or its associated diabetes, as well as the mechanism involved.MethodsThe expression levels of Bhmt were examined in stromal vascular fraction cells and mature adipocytes in obesity and nonobesity. Knockdown and overexpression of Bhmt in C3H10T1/2 cells were used to investigate Bhmt's function in adipogenesis. Bhmt's role in vivo was analyzed using an adenovirus‐expressing system and a high‐fat diet–induced obesity mouse model.ResultsBhmt was highly expressed in stromal vascular fraction cells rather than mature adipocytes of adipose tissue and was upregulated in adipose tissue in obesity and C3H10T1/2‐commited preadipocytes. Overexpression of Bhmt promoted adipocyte commitment and differentiation in vitro and exacerbated adipose tissue expansion in vivo, with a concomitant increase in insulin resistance, whereas Bhmt silencing exhibited opposite effects. Mechanistically, Bhmt‐induced adipose expansion was mediated by stimulating the p38 MAPK/Smad pathway.ConclusionsThe findings of this study highlight the obesogenic and diabetogenic role of adipocytic Bhmt and propose Bhmt as a promising therapeutic target for obesity and obesity‐related diabetes.
Liraglutide versus semaglutide for weight reduction—a cost needed to treat analysis
Authors: Azuri Joseph , Hammerman Ariel , Aboalhasan Enis , Sluckis Ben , Arbel Ronen 
Published: May 2023

AbstractObjectiveHigher doses of the glucagon‐like peptide‐1 agonists liraglutide and, more recently, semaglutide have demonstrated a significant reduction in body weight. However, their comparative value for money for this indication is unclear.MethodsThe cost needed to treat to achieve a 1% reduction in body weight using semaglutide or liraglutide was calculated. The body weight reductions were extracted from the published STEP 1 trial and the SCALE trial results, respectively. A scenario analysis was performed to mitigate the primary differences between the two studies' populations. Drug costs were based on US GoodRx prices as of October 2022.ResultsLiraglutide in STEP 1 resulted in a weight loss of 5.4% (95% CI: 5%‐5.8%). Semaglutide in SCALE resulted in a weight loss of 12.4% (95% CI: 11.5%‐13.4%). The total cost of therapy with liraglutide during the trial was estimated at $17,585 compared with $22,878 with semaglutide. Accordingly, the cost needed to treat per 1% of body weight reduction with liraglutide is estimated at $3256 (95% CI: $3032‐$3517) compared with $1845 (95% CI: $1707‐$1989) with semaglutide.ConclusionsSemaglutide provides significantly better value for money than liraglutide for weight reduction.