bluuebunny/crossref_metadata_2025_split huggingface dataset:
Second generation androgen receptor antagonist, TQB3720 abrogates prostate cancer growth via AR/GPX4 axis activated ferroptosis
Authors: Zhang Zhongqing , Xie Tianlei , Zhang Shun , Yin Haoli , Zhang Xuyu , Zhang Siyuan , Chen Wei , Yu Ding , Qiu Xuefeng , Zhao Wei , Guo Hongqian , Zhuang Junlong 
Published: January 2023

Purpose: Prostate cancer (PCa) poses a great threat to humans. The study aimed to evaluate the potential of TQB3720 in promoting ferroptosis to suppress prostate cancer, providing a theoretical basis for PCa therapy.Methods: PCa cells and nude mice models were divided into TQB3720, enzalutamide (ENZ), and control groups. Sulforhodamine B assay, colony formation assessment, organoids culture system, and the CCK8 assay were used for detecting proliferation. Western blot assay was processed to detect the expression of androgen receptor (AR), ferroptosis, and apoptosis-related genes. Flow cytometry was applied to measure the intracellular ROS levels. ELISA was performed to determine the cellular oxidized glutathione (GSSG) and malondialdehyde (MDA) levels. RT-qPCR was conducted to detect the mRNA expression of genes in AR signaling. BODIPYTM™ 581/591 was processed for detection of intracellular lipid peroxidation levels. The interaction of AR with other translational factor complex proteins was explored using Co-immunoprecipitation (Co-IP), and the chromatin immunoprecipitation (ChIP) assay was performed to detect the binding of AR-involved translational complex to downstream genes promoter. Luciferase reporter assay was conducted to examine the translation activity of GPX4 promoter, and immunohistochemistry (IHC) was conducted to analyze the levels of c-MYC, Ki-67 and AR in TQB3720-treated cancer tissues.Results: Here, we found TQB3720 inhibits the growth of prostate cancer in vitro and in vivo. TQB3720 treatment induced intracellular levels of GSSG and MDA significantly, by which hints AR antagonist caused ferroptosis-related cell death. Moreover, molecular evidence shown TQB3720 regulates downstream of AR signaling by binding AR resulting in inhibition of AR entry into the nucleus. Additional, we also proved that TQB3720 abrogates the interaction between AR and SP1 and leads to decrease GPX4 transcription.Conclusion: TQB3720 promotes ferroptosis in prostate cancer cells by reducing the AR/SP1 transcriptional complex binding to GPX4 promoter. As a result, it is suggested to be a potential drug for clinic prostate cancer treatment.
Chiral uncertainties in ab initio elastic nucleon-nucleus scattering
Authors: Baker Robert B. , Burrows Matthew , Elster Charlotte , Launey Kristina D. , Maris Pieter , Popa Gabriela , Weppner Stephen P. 
Published: January 2023

The effective interaction between a nucleon and a nucleus is one of the most important ingredients for reaction theories. Theoretical formulations were introduced early by Feshbach and Watson, and efforts of deriving and computing those ‘optical potentials’ in a microscopic fashion have a long tradition. However, only recently the leading order term in the Watson multiple scattering approach could be calculated fully ab initio, meaning that the same nucleon-nucleon (NN) interaction enters both the structure as well as the reaction pieces on equal footing. This allows the uncertainties from the underlying chiral effective NN interaction to be systematically explored in nucleon-nucleus elastic scattering observables. In this contribution the main ingredients for arriving at the ab initio leading order of the effective nucleon-nucleus interaction in the Watson approach will be reviewed. Concentrating on one specific chiral NN interaction from the LENPIC collaboration and light nuclei with a 0+ ground state, the leading order nucleon-nucleus interaction is calculated using up to the third chiral order (N2LO) in the nucleon-nucleon potential, and elastic scattering observables are extracted. Then pointwise as well as correlated uncertainty quantification is used for the estimation of the chiral truncation error. Elastic scattering observables for 4He, 12C, and 16O for between 65 and 200 MeV projectile energy will be analyzed.
Assessing proprioception through time-variability properties of acceleration
Authors: Montull Lluc , Borrallo Alex , Almarcha Maricarmen , Balagué Natàlia 
Published: January 2023

Proprioception is a crucial property for movement stability and balance, but its current assessment, based on clinical testing, lacks precision and adequacy in real contexts. This study proposes assessing proprioception and its sensitivity to training effects through acceleration time series recorded during two slackline experiments. In the first experiment, slackliners of different expertise (highly and poorly trained) had to walk on a slackline for 30 s. In the second, twelve beginners had to balance up on the slackline for at least 11 s before and after a training process. Acceleration time series were recorded in body components (legs and centre of mass) and the slackline. The acceleration fluctuations were analysed through Detrended Fluctuation Analysis. The obtained Hurst (H)-exponents were compared between both groups (first experiment) and before and after training (second experiment) using Whitney and Wilcoxon tests, respectively. The values of H-exponents were lower in the highly trained group (Z = −2.15, p = 0.03) (first experiment), and in the post-training conditions (Z = −2.35, p = 0.02) (second experiment). These results suggest better motor and proprioceptive control with training status. Hence, the time-variability structure of acceleration in real contexts, like slackline tasks, is proposed as an objective measure of proprioception and its training effects.
The predictors of spiritual dryness among Iranian cancer patients during the COVID-19 pandemic
Authors: Farahani Azam Shirinabadi , Kerdar Sara Hamideh , Ashrafizadeh Hadis , Büssing Arndt , Mehrnoush Nasrin , Akbari Mohammad Esmaeil , Karami Maryam , Tajalli Salehe , Mojen Leila Khanali , Rassouli Maryam 
Published: January 2023

BackgroundSpiritual struggles affect the wellbeing of religious people. Among them are strugglers with God which is perceived as non-responsive and distant. These perceptions were so far analyzed predominantly in Western societies with a Christian background, but not in Muslims from Iran. The aim of this study was to determine the predictors of spiritual dryness among cancer patients in Iran during the COVID-19 pandemic.MethodsCross-sectional study with standardized questionnaires (i.e., Spiritual Dryness Scale, WHO-5, BMLSS-10, Awe/Gratitude Scale) among 490 cancer patients (mean age 49.50 ± 14.92 years) referring to the selected educational hospitals in Tehran (the capital of Iran), who were selected through convenience sampling and based on the inclusion criteria, enrolled between December 2020–May 2021. Data analysis was done using SPSS software version 26 and the statistical methods including calculating the mean and the standard deviation, correlation coefficients, as well as regression analysis.ResultsThe overall experience of spiritual dryness was perceived regularly in 10.2% of Iranian cancer patients, sometimes in 22.9%, rarely in 22.9%, and never in 43.3%. The mean ± SD was 25.66 ± 5.04, and the scores ranged from 10 to 55. A higher score means greater spiritual dryness. The strongest predictors of spiritual dryness were praying activities Furthermore, the perception of burden due to the pandemic was positively correlated with spiritual dryness. Moreover, each 1 unit increase in its score changed the spiritual dryness score by 0.2 units. The regression of spirituality-related indicators, demographic-clinical variables, and health-related behaviors accounted for 21, 6, and 4% of the total SDS variance, respectively. These findings show that with an increase in praying, performing daily prayers, and the indicators related to spirituality, spiritual dryness will decrease. Most patients were able to cope with these phases often or even regularly, while 31.1% were never or rarely only able to cope.ConclusionThe results of this study showed that in times of crisis, cancer patients’ faith and confidence in God could be challenged. It is not the disease itself which seems to be associated with this form of crisis, but their religious practices. Therefore, it is necessary to support these patients during their struggle, especially as spirituality is one of the best approaches to cope with the disease.
Intergenerational residential school attendance and increased substance use among First Nation adults living off-reserve: An analysis of the aboriginal peoples survey 2017
Authors: Toombs Elaine , Lund Jessie I. , Mushquash Aislin R. , Mushquash Christopher J. 
Published: January 2023

IntroductionThe Truth and Reconciliation Commission of Canada (TRCC) published 94 Calls to Action in 2015 to address long-term, intergenerational effects of the residential school system, highlighting the pervasive impact of colonialism on the wellbeing of Indigenous peoples in Canada. Indeed, research with Indigenous populations in Canada has captured that prior experiences of residential schools contributes to the intergenerational transmission of mental and physical health disparities. Despite these studies, further research is needed that contextualizes the influence of residential schools within broader frameworks that consider Indigenous social determinants of health in Canada. As such, the purpose of the present study was to examine patterns of substance use and mental and physical health among individuals with a history of residential school attendance (RSA) and individuals reporting parent or two-generation (parent and grandparent) RSA.MethodData from the Aboriginal Peoples Survey (2017), involving 10,030 First Nations individuals living off reserve, were analyzed.ResultsSelf-reported mental and physical health scores were significantly lower among those had attended residential schools, whose parents attended residential schools, and whose grandparents attended residential schools, when compared to those who did not. Further, family RSA was associated with increased substance use among participants, though the findings were variable based on sex and specific substance analyzed. Meanwhile, individual and family RSA was not associated with increased likelihood of a mental health diagnosis.DiscussionThese findings provide additional support for how both parental and two-generation family histories of RSA are associated with individual physical and mental health outcomes. Further, these findings articulate the need for the TRCC's Calls to Action to be actually implemented, including community-based approaches that harness the strength of Indigenous people and communities who aim to close the gap in these health disparities for their children and families.
Survey on public awareness, attitudes and self-protective behavior adoption in different periods of COVID-19
Authors: Fang Fang , Chen Sijie , Geng Xianhui , Kiprop Emmanuel 
Published: January 2023

IntroductionThe outbreak and spread of the pandemics have been an issue of critical concern globally, posing a significant threat to the health sector globally. This study aimed to examine the basic knowledge and attitudes toward the recommended protective measures at different times, respond to the COVID-19 pandemic, and provide recommendations for developing targeted strategies and measures for preventing and controlling public health emergencies.MethodsThe study used self-filled questionnaires to examine the public's knowledge, attitudes, and practices on COVID-19 at two different period, from 20 to 31 March 2020 (the beginning period) and 22–27 April 2022 (the regular epidemic prevention and control period). Descriptive and quantitative analyses were used for statistical analysis.Results and discussionThe survey collected 2375 valid questionnaires. A comparison of the two periods reveals that as the epidemic continued over a long period, the level of knowledge, attitudes toward preventive measures, risk perceptions, and adoption behavior of the respondents at the beginning of the epidemic were significantly higher than during the regular epidemic prevention and control period. With the upsurge in the spread of the epidemic, the public needs a multi-channel, targeted, and all-round guidance and information on prevention and control of the COVID-19, and internalizes knowledge into individual's behavior of actively responding to diseases.When the epidemic lasts for a long time, the relevant agencies should strengthen their monitoring role to promote public compliance with the recommended measures.
Effects of functional limitations and activities of daily living on the mortality of the older people: A cohort study in China
Authors: Gao Yumeng , Du Liang , Cai Jianping , Hu Tingfa 
Published: January 2023

IntroductionPrevalence of functional limitations (FLs) and disabled activities of daily living (ADL) cause heavy burdens to the health of the older people. Stratified by gender, this study aimed to explore the effects of FL and ADL on the mortality of the older people in China, and the mechanism was then discussed.MethodsWe used survey data of a prospective 10-year cohort (2008–2018), from the China Longitudinal Healthy Longevity Survey (CLHLS). The primary outcome was all-cause mortality, and Independent variables included FL, basic ADL (BADL), and instrumental ADL (IADL). Covariates involved socio-demographic characteristics, health-related behaviors, and health status of the participants in the CLHLS project.ResultsThere were 967 (19.20%) male and 2,235 (32.36%) female older people performed functional limitations, and their survival time was 60.98 (SE = 0.66) and 55.19 (SE = 0.55) months, respectively. Old adults with FL had significantly poorer survival than the ones without (Log-rank test, P &lt; 0.001). Weibull regression suggested that FL (P &lt; 0.001), abnormal BADL (P &lt; 0.001) and IADL (P &lt; 0.001) were negatively associated with the survival of the older people. Further analysis showed that BADL and IADL performed significantly mediating roles in the relation of FL and survival time in old adults; additionally, for female older people, BADL also exhibited a significant moderating role in the effect of FL on survival.ConclusionsPrevalence of FL was serious among the older people in China, especially for the women. Disabilities of BADL and IADL and FL were negatively associated with the survival time of the older people in China. Regarding the effect of FL on survival, BADL and IADL performed significantly mediating roles, and the moderating role of BADL existed only for the female. These suggested evidence to implement strategies to maintain health in the older people.
Evaluating the implementation of a multi-level mHealth study to improve hydroxyurea utilization in sickle cell disease
Authors: Hankins J. S , Potter M. B , Fernandez M. E , Melvin C , DiMartino L , Jacobs S. R , Bosworth H. B , King A. A , Simon J , Glassberg J. A , Kutlar A , Gordeuk V. R , Shah N , Baumann A. A , Klesges L. M ,   the Sickle Cell Disease Implementation Consortium
Published: January 2023

BackgroundSickle Cell Disease (SCD) is a progressive genetic disease that causes organ damage and reduces longevity. Hydroxyurea is an underutilized evidence-based medication that reduces complications and improves survival in SCD. In a multi-site clinical trial, part of the NIH-funded Sickle Cell Disease Implementation Consortium (SCDIC), we evaluate the implementation of a multi-level and multi-component mobile health (mHealth) patient and provider intervention to target the determinants and context of low hydroxyurea use. Given the complexity of the intervention and contextual variability in its implementation, we combined different behavioral and implementation theories, models, and frameworks to facilitate the evaluation of the intervention implementation. In this report, we describe engagement with stakeholders, planning of the implementation process, and final analytical plan to evaluate the implementation outcomes.MethodsDuring 19 meetings, a 16-member multidisciplinary SCDIC implementation team created, conceived, and implemented a project that utilized Intervention Mapping to guide designing an intervention and its evaluation plan. The process included five steps: (1) needs assessment of low hydroxyurea utilization, (2) conceptual framework development, (3) intervention design process, (4) selection of models and frameworks, and (5) designing evaluation of the intervention implementation.ResultsBehavioral theories guided the needs assessment and the design of the multi-level mHealth intervention. In designing the evaluation approach, we combined two implementation frameworks to best account for the contextual complexity at the organizational, provider, and patient levels: (1) the Consolidated Framework for Implementation Research (CFIR) that details barriers and facilitators to implementing the mHealth intervention at multiple levels (users, organization, intervention characteristics, broader community), and (2) the Technology Acceptance Model (TAM), a conceptual model specific for explaining the intent to use new information technology (including mHealth). The Reach Effectiveness Adoption Implementation and Maintenance (RE-AIM) framework was used to measure the outcomes.DiscussionOur research project can serve as a case study of a potential approach to combining different models/frameworks to help organize and plan the evaluation of interventions to increase medication adherence. The description of our process may serve as a blueprint for future studies developing and testing new strategies to foster evidence-based treatments for individuals living with SCD.
Coronary artery bypass grafting vs. percutaneous coronary intervention in coronary artery disease patients with advanced chronic kidney disease: A Chinese single-center study
Authors: Li Yang , Hou Xuejian , Xu Xiaoyu , Huang Zhuhui , Liu Taoshuai , Xu Shijun , Rui Hongliang , Zheng Jubing , Dong Ran 
Published: January 2023

ObjectivesAims to compare the contemporary and long-term outcomes of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in coronary artery disease (CAD) patients with advanced chronic kidney disease (CKD).Methods823 CAD patients with advanced CKD (eGFR &lt; 30 ml/min/1.73 m2) were collected, including 247 patients who underwent CABG and 576 patients received PCI from January 2014 to February 2021. The primary endpoint was all-cause death. The secondary endpoints included major adverse cardiac and cerebrovascular events (MACCEs), myocardial infarction (MI), stroke and revascularization.ResultsMultivariable Cox regression models were used and propensity score matching (PSM) was also performed. After PSM, the 30-day mortality rate in the CABG group was higher than that in the PCI group but without statistically significant (6.6% vs. 2.4%, p = 0.24). During the first year, patients referred for CABG had a hazard ratio (HR) of 1.42 [95% confidence interval (CI), 0.41–3.01] for mortality compared with PCI. At the end of the 5-year follow-up, CABG group had a HR of 0.58 (95%CI, 0.38–0.86) for repeat revascularization, a HR of 0.77 (95%CI, 0.52–1.14) for survival rate and a HR of 0.88(95%CI, 0.56–1.18) for MACCEs as compared to PCI.ConclusionsAmong patients with CAD and advanced CKD who underwent CABG or PCI, the all-cause mortality and MACCEs were comparable between the two groups in 30 days, 1-year and 5 years. However, CABG was only associated with a significantly lower risk for repeat revascularization compared with PCI at 5 years follow-up.
Antropologia, desejo e texturas da vida: uma entrevista com Veena Das
Authors: Sarti Cynthia , Pierobon Camila , Ferreira Letícia , Das Veena , Vianna Adriana , Gambarotto Bruno 
Published: January 2023

Entrevista com Veena Das, por Camila Pierobon, Letícia Ferreira, Adriana Vianna e Cynthia Sarti.
Indicators Сharacterizing the Ability to Orientate’s Problem in Disabled Children Due to Pathology of Vision Organ Aged to 6 Years
Authors: В.В. Голикова, , И.Т. Дорошенко, , А.В. Бояровская, , К.В. Голикова, , М.В. Амельченя, , Н.А. Захарова, 
Published: January 2023

Цель. Разработка показателей, характеризующих ограничение способности к ориентации у детей-инвалидов вследствие патологии органа зрения в возрасте до 6 лет. Материалы и методы. Было проведено клинико-экспертное исследование с оценкой степени выраженности нарушения функций органов и систем организма, оценкой степени выраженности ограничения категорий жизнедеятельности 54 детей-инвалидов в возрасте до 6 лет с патологией органа зрения. Результаты. По результатам проведенного клинико-экспертного исследования детей-инвалидов с патологией органа зрения в возрасте до 6 лет было установлено, что формирование ограничения способности к ориентации обусловлено влиянием остроты зрения на лучше видящем глазу (r=–0,57, р<0,05) и на хуже видящем (r=–0,43, р<0,05), а также нарушением зрительных реакций на лучше видящем (r=–0,84, р<0,05) и на хуже видящем (r=–0,81, р<0,05) глазу. Выводы. Полученные результаты исследования позволили разработать показатели зрительных нарушений, характеризующих различные степени ограничения способности к ориентации у детей-инвалидов вследствие патологии органа зрения в возрасте до 6 лет.
Purpose. Development of indicators characterizing the ability to orientate’s problem in disabled children due to pathology of vision organ aged to 6 years. Materials and methods. The clinical assessment study was conducted assessment of the severity of functions impairments of body’s organs and systems, assessment of the severity of problems of vital activity categories in 54 disabled children aged to 6 years with pathology of the organ of vision. Results. According to the results of the clinical assessment of children with disabilities due to pathology of vision organ aged to 6 years, it was found that formation the ability to orientate’s problem was due to the influence of visual acuity in the best seeing eye (r=–0.57, p<0.05) and the worse seeing (r=–0.43, p<0.05), as well as impaired visual reactions in the best seeing eye (r=–0.84, p<0.05) and in the visually impaired (r=–0.81, p<0.05). Conclusions. The obtained results of the study made it possible to develop visual impairments’s indicators of that characterize of indicators characterizing the severity of problems of the ability to orientate’s problem in disabled children due to pathology of vision organ aged to 6 years.
SPICE compact model of controlling electrons of spin qubits using FinFET
Authors: Pérez-Rodríguez Elias A. , Orvañanos-Guerrero María T. , Tanamoto Tetsufumi 
Published: January 2023

AbstractSemiconductor qubits have garnered attention in the field of device physics. Owing to the limited coherence of electrons and holes, smaller and more compact qubits are desirable. This requirement is aligned with the miniaturization of conventional transistors. In this study, we consider a compact spin qubit based on the FinFET (Fin Field-Effect Transistor) by using the SPICE (Simulation Program with Integrated Circuit Emphasis) simulator. The qubits are represented by the quantum dots (QDs) between the Fin structure. In order to setup the qubit, we have to control the number of electrons through the FinFET. Here, we consider the circuit model of our system by treating the transport properties of the QD and the FinFET as single-electron phenomena. We provide the SPICE simulation results and show the single-electron current as the functions of the FinFET parameters such as the channel length and width including the operation temperature.