bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor-Faktor Yang Berhubungan Dengan Perilaku BABS Di Wilayah Kerja Puskesmas Siulak Gedang
Authors: Imani Weci Refira , Nur Erdi , Awaluddin Awaludin , Adriyanti Sri Lestari 
Published: June 2023

Open Defecation Free (ODF) is an activity directed at changing the behavior of Open defecationtoward latrines. Based on the data obtained, there are 10 villages with a total of 457 households that have not been verified as open defecation free. The purpose of this study was to determine the factors related to open defecation behavior in the Siulak Gedang Health Center Work Area, Kerinci Regency in 2022. This research was a quantitative study with the approach cross sectional conducted in two villages in the Siulak Gedang Health Center Work Area. . The population in this study were all households in the village with high open defecation status, namely Siulak Gedang Village and Pelak Naneh Village as many as 515 families, with a sample of 100 families. Data was collected through interviews using a questionnaire. Data analysis with univariate and bivariate with statistical chi-square test. The results showed that there was a relationship between knowledge (p = 0.003), attitude (p = 0.000), socioeconomic (p = 0.002), and latrine ownership (p = 0.000) with open defecation behavior. There was no relationship between the support of health workers (p=1) with open defecation behavior. To reduce the number of open defecation (OD), it is hoped that the community always participates in implementing clean and healthy living behaviors, especially in the ownership and use of healthy family latrines.
Analisis Risiko Logam Berat Cr dan Cu Pada DAS Cilamaya
Authors: Sopian Sabiha Mawaddah , Cahyani Intan , Manenti Dini Auliana , Alifiana Winanda , Listriyani Ayu Suranti 
Published: June 2023

The existence of human activities around the watershed can cause polluted water, one of the pollutant substances is heavy metals. The purpose of this study was to measure the concentration and analyze the risk of exposure to metals contained in river water. This research was conducted in the Cilamaya River, West Java Province. Sampling was carried out 3 times in March, June and October 2021 at 4 different sampling points. The data used is secondary data from the Department of Environment and Forestry of West Java Province and then calculated and analyzed using the equation formula. The results of this study indicate that the risk of Cr heavy metal contamination at points 1-4 is 0.010958904. Meanwhile, the risk of Cu heavy metal contamination at point 1-4 is 0.0109589. Then the risk value for both Cu and Cr metals is ≤ 1, which means that the Cilamaya watershed is not at risk.
High-pressure synthesis and magnetic properties of tetragonal R2BaCuO5 (R = Sm and Eu)
Authors: Mishra Swarnamayee , Yanda Premakumar , Bhat Shrikant , Etter Martin , Sundaresan A. 
Published: June 2023

We report the experimental discovery of a new structural phase of well-known orthorhombic R2BaCuO5 (R = Sm and Eu), exhibiting a tetragonal crystal structure with space group P4∕mbm. The high-pressure tetragonal phase is isostructural with the brown phase R2BaCuO5 (R = La, Pr, and Nd). In this structure, the Cu ions form an isolated square planar environment, contrary to the orthorhombic phase, where the Cu ions are located in a distorted square pyramid. Magnetization and specific heat measurements reveal the long-range antiferromagnetic order of the Cu2+ and/or Sm3+ moments for the Sm-sample, with the magnetic specific heat accounting for only 35% of the magnetic entropy. Interestingly, the Eu-sample remains paramagnetic down to the lowest temperature. The high Curie-Weiss temperature of −140 K and magnetic entropy of 3% of the expected value indicates that the system is highly frustrated. We estimated the isothermal entropy change and investigated the magnetocaloric effect for Eu2BaCuO5, and the maximum entropy change detected at a field of 70 kOe at 3 K reaches 5.6 J kg-1K−1.
Change in blood pressure status defined by 2017 ACC/AHA hypertension guideline and risk of cardiovascular disease: results of over a decade of follow-up of the Iranian population
Authors: Kabootari Maryam , Tamehri Zadeh Seyed Saeed , Hasheminia Mitra , Azizi Fereidoun , Hadaegh Farzad 
Published: June 2023

BackgroundHypertension (HTN) is known to be the leading cause of cardiovascular disease (CVD) and mortality. We aimed to assess the impact of changes in 3 years in different blood pressure (BP) categories on incident CVD.MethodsIn this study, 3,685 Tehranians aged ≥30 years (42.2% men) free of prevalent CVD with BP level &lt;140/90 mmHg and not on BP-lowering medications were enrolled. Participants were grouped according to baseline BP category using the 2017 ACC/AHA hypertension guideline definition: normal BP (&lt;120/80 mmHg), elevated BP (120–129/&lt;80), and stage 1 HTN (130–139 and/or 80–89). The hazard ratio of incident CVD by changes in the BP category was estimated after adjustment for traditional risk factors using Cox's proportional hazard model, with stable normotension as a reference.ResultsDuring a median follow-up of 11.7 years, 346 CVD events (men = 208) occurred. Compared to the reference group, among participants with normal BP at baseline, only those with BP rising to stage 1 HTN [1.47 (0.99–2.16)], and among those with stage 1 HTN at baseline, regression to elevated BP [1.80 (1.11–2.91)], remaining at stage 1 [1.80 (1.29–2.52)], and progression to stage 2 HTN [1.81 (1.25–2.61)] had a higher risk for CVD; however, regression to normal BP attenuated this risk [1.36 (0.88–2.12)]. Conversion from elevated BP to any other categories had no significant association with CVD risk.ConclusionsGenerally, prevalent stage 1 HTN (regardless of changing category) and incident stage 1 HTN were significantly associated with a higher risk of CVD; even regression to elevated BP did not attenuate the risk. Accordingly, these populations are potential candidates for antihypertensive management.
Early-life exposure to endocrine-disrupting chemicals and autistic traits in childhood and adolescence: a systematic review of epidemiological studies
Authors: Cunha Yandra Giovanna de Oliveira , Amaral Giovanna Cavalcanti Brito do , Felix Alana Almeida , Blumberg Bruce , Amato Angelica Amorim 
Published: June 2023

AimsExposure to endocrine-disrupting chemicals (EDCs) during critical neurodevelopmental windows has been associated with the risk of autistic traits. This systematic review of epidemiological studies examined the association between maternal exposure to EDCs during pregnancy and the risk of autism spectrum disorder (ASD) in the offspring.MethodsWe searched PubMed, Web of Science, Scopus, and Google Scholar from inception to November 17, 2022, for studies investigating the association between prenatal exposure to EDCs and outcomes related to ASD. Two independent reviewers screened studies for eligibility, extracted data, and assessed the risk of bias. The review was registered in PROSPERO (CRD42023389386).ResultsWe included 27 observational studies assessing prenatal exposure to phthalates (8 studies), polychlorinated biphenyls (8 studies), organophosphate pesticides (8 studies), phenols (7 studies), perfluoroalkyl substances (6 studies), organochlorine pesticides (5 studies), brominated flame retardants (3 studies), dioxins (1 study), and parabens (1 study). The number of examined children ranged from 77 to 1,556, the age at the assessment of autistic traits ranged from 3 to 14 years, and most studies assessed autistic traits using the Social Responsiveness Scale. All but one study was considered to have a low risk of bias. Overall, there was no association between maternal exposure to specific ECDs during pregnancy and the occurrence of autistic traits in offspring.ConclusionsFindings from the epidemiological studies evaluated here do not support an association between prenatal exposure to ECDs and the likelihood of autistic traits in later in life. These findings should not be interpreted as definitive evidence of the absence of neurodevelopment effects of EDCs affecting ASD risk, given the limitations of current studies such as representative exposure assessment, small sample sizes, inadequacy to assess sexually dimorphic effects, or the effects of EDC mixtures. Future studies should carefully address these limitations.
Research on flood sediments and rainstorm events in Huangtuwa, Northern Shaanxi
Authors: Shi Hao , Yue Dapeng , Zhao Jingbo , Wang Xiaoning 
Published: June 2023

The research purpose of this paper is to reveal the relationship between flood deposits, rainfall and flooding in the Loess Plateau over the last 50 years. The research in this paper is of great significance as it reveals the torrential flood events and soil erosion in the central region of the Loess Plateau. Through grading analysis and 137Cs content determination of a closed lake sedimentary profile formed by landslide-blocked rivers in middle part of Loess Plateau, Zizhou County, Shaanxi Province, the age of the sedimentary formation in the section, as well as the rainstorm events and changes of soil erosion since 1954 are studied. The results show that the sediment particle size composition in the study section is fine, mainly comprising of coarse silt, while the content of sand particles (&gt;100 μm) is very low. The changes in137Cs content show that the sedimentary layer at a depth of 280–210 cm in the research profile was formed between 1954 and 1964, while the deep sedimentary layer at 210–70 cm was formed between 1965 and 1986 and the sedimentary layer above 70 cm depth was formed between 1987 and 2011. In total, 20 coarse particle layers (particle size &gt;50 μm) were deposited in the lake between 1954 and 2011. The sedimentation timing of the 20 coarse particle layers was basically consistent with the timing of rainstorm events (daily rainfall ≥60 mm) in the study area, indicating that the coarse particle sediments in the lake represent rainstorm events. Soil erosion was stronger between 1954 and 1985 and was weaker after 1986.
Diversified responses of vegetation carbon uptake to urbanization: a national-scale analysis
Authors: Zhang Xueliang , Qiu Dai , Xie Yichun , Tu Jianguang , Lan Hai , Li Xiaolei , Sha Zongyao 
Published: June 2023

IntroductionUrbanization converts vegetated lands into impervious surfaces and often degrades vegetation carbon sequestration in urban ecosystems. At the same time, the impact on urban vegetation growth from urban expansion could be spatially diverse given different natural environments and urban management practices.MethodsHere we applied time-series remotely sensed images and analyzed the urban growth for all the prefecture-level cities across China during 2001–2019, and compared the impact of urbanization on vegetation carbon uptake proxied by MODIS (MOD17A2H) net primary productivity (NPP) on Google Earth Engine platform.ResultsThe result indicated that at the national scale, the carbon uptake flux in urban areas was only 19% compared to that in the nonurban vegetated counterparts. The total urban area expanded by 22% and the vegetation carbon uptake in the newly urbanized zones was averagely reduced by 16% during the period, but with high spatio-temporal heterogeneity among cities and with exceptions demonstrating even improved NPP, highlighting diversified responses of vegetation carbon sequestration to urban sprawl. The changes of vegetation carbon sequestration in response to urbanization were found to be spatially clustered.DiscussionWe conclude that urban land management strategies unique to cities may attribute to the diversified responses of vegetation carbon capture to urbanization.
Taxonomic relationship among four European Physokermes species (Hemiptera: Coccomorpha) based on nuclear and mitochondrial DNA
Authors: Marques Joana F. , Winde Inis , Jönsson Anna Maria , Anderbrant Olle 
Published: June 2023

IntroductionScale insects (Hemiptera: Coccomorpha) feed on a wide variety of agricultural crops and forest and ornamental trees worldwide. These pest insects damage plants not only by causing sap loss but also by reducing the plant's photosynthetic activity. This is because the honeydew they produce acts as a substrate for mold, which covers leaf surfaces. In the last decades, several outbreaks of Physokermes spp. (soft-scale insects) have occurred throughout Europe and have partly been attributed to unusual weather conditions or climate change, as some species seem to be expanding their distribution range. However, the small size of these insects and their large intraspecific morphological variation have hindered the identification of the species responsible for outbreaks.MethodsIn this study, mitochondrial DNA (cytochrome c oxidase subunit I, COI), ribosomal RNA (28S), and nuclear (elongation factor 1α, EF1α) DNA markers were used to reconstruct the phylogenetic relationships of four Physokermes species sampled throughout Europe in 2013–2015.Results and discussionThe results allowed us to clearly distinguish P. hellenicus and P. inopinatus from each other, as these appeared in well-supported clades in the phylogenetic trees and from P. piceae and P. hemicryphys. However, P. hemicryphus appeared in a single clade in trees based on 28S and EF1α but among P. piceae in the COI tree. Further investigations are therefore required to determine the taxonomic status of P. piceae and P. hemicryphys, which seem to comprise a species complex.
Pyroptosis-related genes GSDMB, GSDMC, and AIM2 polymorphisms are associated with risk of non-small cell lung cancer in a Chinese Han population
Authors: Zhang Xia , Liu Rongfeng 
Published: June 2023

Background: Pyroptosis is essential for the remodeling of tumor immune microenvironment and suppression of tumor development. However, there is little information available about pyroptosis-related gene polymorphisms in non-small cell lung cancer (NSCLC).Methods: Six SNPs in the GSDMB, GSDMC, and AIM2 were genotyped in 650 NSCLC cases and 650 healthy controls using a MassARRAY platform.Results: Minor alleles of rs8067378, rs2305480, and rs77681114 were associated with a lower risk of NSCLC (p &lt; 0.005), whereas rs2290400 and rs1103577 were related to an increased risk (p &lt; 0.00001). Moreover, rs8067378-AG/GG, rs2305480-GA/AA, and rs77681114-GA/AA genotypes were associated with a decrease in NSCLC risk (p &lt; 0.005). In contrast, the TC/CC genotypes of rs2290400 and rs1103577 were associated with an elevated NSCLC risk (p &lt; 0.0001). Based on the analysis of genetic models, minor alleles of rs8067378, rs2305480 and rs77681114 were related to reduced risk of NSCLC (p &lt; 0.05); whereas rs2290400 and rs1103577 were related to increased risk (p &lt; 0.01).Conclusion: Our findings provided new insights into the roles of pyroptosis-related genes in NSCLC, as well as new factors to be considered for assessing the risk of developing this cancer.
Attempts to evaluate locus suicide recombination and its potential role in B cell negative selection in the mouse
Authors: Denis-Lagache Nicolas , Oblet Christelle , Marchiol Tiffany , Baylet Audrey , Têteau Ophélie , Dalloul Iman , Dalloul Zeinab , Zawil Lina , Dézé Ophélie , Cook-Moreau Jeanne , Saintamand Alexis , Boutouil Hend , Khamlichi Ahmed Amine , Carrion Claire , Péron Sophie , Le Noir Sandrine , Laffleur Brice , Cogné Michel 
Published: June 2023

IntroductionIn mature B cells, activation-induced deaminase reshapes Ig genes through somatic hypermutation and class switch recombination of the Ig heavy chain (IgH) locus under control of its 3’ cis-regulatory region (3’RR). The 3’RR is itself transcribed and can undergo “locus suicide recombination” (LSR), then deleting the constant gene cluster and terminating IgH expression. The relative contribution of LSR to B cell negative selection remains to be determined.MethodsHere, we set up a knock-in mouse reporter model for LSR events with the aim to get clearer insights into the circumstances triggering LSR. In order to explore the consequences of LSR defects, we reciprocally explored the presence of autoantibodies in various mutant mouse lines in which LSR was perturbed by the lack of Sµ or of the 3’RR.ResultsEvaluation of LSR events in a dedicated reporter mouse model showed their occurrence in various conditions of B cell activation, notably in antigen-experienced B cells Studies of mice with LSR defects evidenced increased amounts of self-reactive antibodies.DiscussionWhile the activation pathways associated with LSR are diverse, in vivo as well as in vitro, this study suggests that LSR may contribute to the elimination of self-reactive B cells.
Comparison of video laryngoscopy with direct laryngoscopy for intubation success in critically ill patients: a systematic review and Bayesian network meta-analysis
Authors: Kim Jae Guk , Ahn Chiwon , Kim Wonhee , Lim Tae-Ho , Jang Bo-Hyong , Cho Youngsuk , Shin Hyungoo , Lee Heekyung , Lee Juncheol , Choi Kyu-Sun , Na Min Kyun , Kwon Sae Min 
Published: June 2023

IntroductionThis review compares the efficacy of video laryngoscopy (VL) with direct laryngoscopy (DL) for successful tracheal intubation in critically ill or emergency-care patients.MethodsWe searched the MEDLINE, Embase, and Cochrane Library databases for randomized controlled trials (RCTs) that compared one or more video laryngoscopes to DL. Sensitivity analysis, subgroup analysis, and network meta-analysis were used to investigate factors potentially influencing the efficacy of VL. The primary outcome was the success rate of first-attempt intubation.ResultsThis meta-analysis included 4244 patients from 22 RCTs. After sensitivity analysis, the pooled analysis revealed no significant difference in the success rate between VL and DL (VL vs. DL, 77.3% vs. 75.3%, respectively; OR, 1.36; 95% CI, 0.84–2.20; I2 = 80%; low-quality evidence). However, based on a moderate certainty of evidence, VL outperformed DL in the subgroup analyses of intubation associated with difficult airways, inexperienced practitioners, or in-hospital settings. In the network meta-analysis comparing VL blade types, nonchanneled angular VL provided the best outcomes. The nonchanneled Macintosh video laryngoscope ranked second, and DL ranked third. Channeled VL was associated with the worst treatment outcomes.DiscussionThis pooled analysis found, with a low certainty of evidence, that VL does not improve intubation success relative to DL. Channeled VL had low efficacy in terms of intubation success compared with nonchanneled VL and DL.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=285702, identifier: CRD42021285702.
Divergent endophytic viromes and phage genome repertoires among banana (Musa) species
Authors: Aghdam Shiva A. , Lahowetz Rachel M. , Brown Amanda M. V. 
Published: June 2023

IntroductionViruses generally cause disease, but some viruses may be beneficial as resident regulators of their hosts or host microbiomes. Plant-associated viruses can help plants survive by increasing stress tolerance or regulating endophytic communities. The goal of this study was to characterize endophytic virus communities in banana and plantain (Musa spp.) genotypes, including cultivated and wild species, to assess virome repertoires and detect novel viruses.MethodsDNA viral communities were characterized by shotgun sequencing of an enriched endosphere extract from leaves and roots or corm of 7 distinct Musa genotypes (M. balbisiana, Thai Black, M. textilis, M. sikkimensis, Dwarf Cavendish, Williams Hybrid, and FHIA-25 Hybrid).ResultsResults showed abundant virus-like contigs up to 108,191 bp long with higher relative abundance in leaves than roots. Analyses predicted 733 phage species in 51 families, with little overlap in phage communities among plants. Phage diversity was higher in roots and in diploid wild hosts. Ackermanniviridae and Rhizobium phage were generally the most abundant taxa. A Rhizobium RR1-like phage related to a phage of an endophytic tumor-causing rhizobium was found, bearing a holin gene and a partial Shiga-like toxin gene, raising interest in its potential to regulate endophytic Rhizobiaceae. Klebsiella phages were of interest for possible protection against Fusarium wilt, and other phages were predicted with potential to regulate Erwinia, Pectobacterium, and Ralstonia-associated diseases. Although abundant phage-containing contigs were functionally annotated, revealing 1,038 predicted viral protein domains, gene repertoires showed high divergence from database sequences, suggesting novel phages in these banana cultivars. Plant DNA viruses included 56 species of Badnavirus and 26 additional non-Musa plant viruses with distributions that suggested a mixture of resident and transient plant DNA viruses in these samples.DiscussionTogether, the disparate viral communities in these plants from a shared environment suggest hosts drive the composition of these virus communities. This study forms a first step in understanding the endophytic virome in this globally important food crop, which is currently threatened by fungal, bacterial, and viral diseases.
Nutrient availability and acid erosion determine the early colonization of limestone by lithobiontic microorganisms
Authors: Chen Jin , Zhao Qing , Li Fangbing , Zhao Xiangwei , Wang Yang , Zhang Limin , Liu Jinan , Yan Lingbin , Yu Lifei 
Published: June 2023

IntroductionMicroorganisms, including the pioneer microorganisms that play a role in the early colonization of rock, are extremely important biological factors in rock deterioration. The interaction of microorganisms with limestone leads to biodeterioration, accelerates soil formation, and plays an important role in the restoration of degraded ecosystems that cannot be ignored. However, the process of microbial colonization of sterile limestone in the early stages of ecological succession is unclear, as are the factors that affect the colonization. Acid erosion (both organic and inorganic), nutrient availability, and water availability are thought to be key factors affecting the colonization of lithobiontic microorganisms.MethodsIn this study, organic acid (Oa), inorganic acid (Ia), inorganic acid + nutrient solution (Ia + Nut), nutrient solution (Nut), and rain shade (RS) treatments were applied to sterilized limestone, and the interaction between microorganisms and limestone was investigated using high-throughput sequencing techniques to assess the microorganisms on the limestone after 60 days of natural placement.ResultsThe results were as follows: (1) The abundance of fungi was higher than that of bacteria in the early colonization of limestone, and the dominant bacterial phyla were Proteobacteria, Bacteroidota, and Actinobacteriota, while the dominant fungal phyla were Ascomycota, Basidiomycota, and Chytridiomycota. (2) Acid erosion and nutrient availability shaped different microbial communities in different ways, with bacteria being more sensitive to the environmental stresses than fungi, and the higher the acidity (Ia and Oa)/nutrient concentration, the greater the differences in microbial communities compared to the control (based on principal coordinate analysis). (3) Fungal communities were highly resistant to environmental stress and competitive, while bacterial communities were highly resilient to environmental stress and stable.DiscussionIn conclusion, our results indicate that limestone exhibits high bioreceptivity and can be rapidly colonized by microorganisms within 60 days in its natural environment, and both nutrient availability and acid erosion of limestone are important determinants of early microbial colonization.