bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Penoscrotal Basal Cell Carcinoma – An Institutional Retrospective Review
Authors: Light Jeremy G. , Muñoz Genevieve , Council M. Laurin 
Published: March 2023

Abstract
Basal cell carcinoma (BCC) of the sun-protected genital region is rare. We examined all penoscrotal BCC at a single institution over an 18-year period. A total of 7 cases were identified, 5 scrotal and 2 penile. Four cases (57%) were treated with Mohs micrographic surgery (MMS) and 3 cases (43%) with conventional excision. A prior retrospective review of vulvar BCC at our institution during the same time period showed that MMS was utilized in 4 (11%) of 35 cases. Functional preservation is vital when performing surgery on the genitals and tissue-sparing MMS provides optimal tumor clearance and outcomes for both males and females.
Leveraging Response Times in Learning Environments: Opportunities and Challenges
Authors: Pelánek Radek 
Published: March 2023

Abstract
Computer-based learning environments can easily collect student response
times. These can be used for multiple purposes, such as modeling student
knowledge and affect, domain modeling, and cheating detection. However, to
fully leverage them, it is essential to understand the properties of response
times and associated caveats. In this study, we delve into the properties of
response time distributions, including the influence of aberrant student
behavior on response times. We then provide an overview of modeling
approaches that use response times and discuss potential applications of
response times for guiding the adaptive behavior of learning environments.
An Energy Efficient VM Selection Using Updated Dragonfly Algorithm in Cloud Computing
Authors: Prashar Ajay , Thakur Jawahar 
Published: March 2023

Abstract
Cloud computing is popular among industries, academia, and government to supply reliable and scalable computational power. High speed networks in cloud data centers connect Virtual machines with Physical Machines. Virtualization assists the cloud service providers to manage resources effectively but unoptimized and inefficient services degrade the performance of the system. The scheduling architecture of cloud computing includes Physical Machines (PMs), Virtual Machines (VMs) and the allocation and migration policy of the VMs over the PMs. The overutilized PMs get a few migrations and this paper introduces a novel behaviour of VM selection from overutilized PM using Swarm intelligence. The evaluation of the proposed algorithm architecture is compared with other state of art optimization algorithm from the same series. The evaluation has been done on the base of Quality of Service (QoS) parameters such as SLA-Violation, energy consumption against various load variation scenario to support elasticity. The proposed work has outcasted other techniques with significant margin in terms of QoS and the illustrations are discussed in the result.
A framework for assessing hazards related to pit lakes – application on European case studies
Authors: ALHEIB MARWAN , VAROUCHAKIS EMMANOUIL , Galetakis Michail , Renaud Vincent , Burda Jan 
Published: March 2023

Abstract
The number of abandoned mines is continuously increasing in the word. The sustainable exploitation of these abandoned mines is a top priority globally. Open-pit lakes created in the abandoned mining site provide benefits and present risks for the mining region. The paper presents a methodology to assess the hazards (mining and natural). The proposed methodology framework is based on well-established and internationally accepted risk management standards and allows the assessment of the long-term stability of pit lakes. Ground movement, water pollution, fire hazards are presented, and their impact evaluated based on feedback and international experiences. The methodology was applied for 13 European open-pit lakes created in former European coal and lignite mines. A risk assessment of Most lake, using qualitative and a weighted probabilistic approach that considers the overall and the individual effect of identified mining and natural hazards, shown that the main potential hazards are the ground movement and the flooding.
Phylogenetics of phyllocladiferous Phyllanthus (Phyllanthaceae): a new section exclusive from the Atlantic Rain Forest, with morphological and molecular support
Authors: Orlandini Priscila , Silva Otávio Luis Marques da , Cordeiro Inês , Souza Vinicius Castro 
Published: March 2023

Abstract
The latest phylogenetic and taxonomic studies emphasizing Phyllanthus(Phyllanthaceae) have significantly altered the relationships between its taxa. In this work, we inferred a phylogeny for the phyllocladiferous species of Phyllanthus, traditionally included within Phyllanthus sects. Choretropsis and Xylophylla from eastern Brazil and Caribbean, respectively. Our analysis demonstrated that these two sections are clearly distinct, but sect. Choretropsis, as it currently stands, does not form a monophyletic group. Thus, phylloclades arose in Phyllanthus at least in five distinct clades. Most species of sect. Choretropsis are recovered among representatives of other groups (sects. Antipodanthus and Phyllanthus subsect. Claussenianii), but no macromorphological feature could be traced for the clades we recovered. One exception is a clade containing P. dracenoides, P. gladiatus and P. pedicellatus, species with dracenoid habit and exclusive to the humid dense forests along Atlantic Forest domain, for which we describe a new section.
Age Operator Deep Sparse Fusion Extension of the Expression Recognition
Authors: Chen Bin , Shen Gang , Fan Feiyan 
Published: March 2023

Abstract
To solve the problem of trait differences in expression characteristics among different age groups, shortage of research on cross-age facial expression analysis, and the lack of datasets across ages, put forward the model in age factor deep sparse fusion extension of the expression recognition. The model utilizes a linear dictionary sequence of a high-level form as an input signal for a sparse representation, the input objects are constructed in a linear combination, and select the optimal solution in all solutions with the sparse level as an indicator, further through the convolutional, pooling and full connection processing of convolutional neural networks, the problems of high similarity, insufficient quantity and uneven distribution of data sets are solved through the fusion extension strategy, on this basis, the age operator is combined as feature elements and expression features are extracted and used as the basis for classification decision. Extension by deep sparse fusion, additional factors were extracted using anthropometric models, internal angle calculation and skin wrinkle detection of age operator as expression features, the comparison of results of multiple dataset experiments demonstrate the effectiveness and stability across datasets of the algorithm, the advantages of this algorithm are also demonstrated by the horizontal alignment of the representative cross-age expression classification algorithm. This method is effective for the accuracy and robustness of expression expressions across ages, it has the research value and the reference significance.
Postoperative noninvasive ventilation and complications after repair of oesophageal atresia-tracheoesophageal fistula (OA-TOF): a retrospective chart review
Authors: Zheng Maye , Ravindranathan Hari , Lui Kei , Krishnan Usha 
Published: March 2023

Abstract
Purpose:
Oesophageal atresia (OA) continues to carry a high morbidity rate despite significant advances in reducing its mortality. The primary aim of this study was to determine if postoperative use of high flow nasal cannula (HFNC) and/or continuous positive airway pressure (CPAP) are independent risk factors for adverse outcomes after surgical repair of OA-TOF.
Methods:
A retrospective chart review was conducted on all OA-TOF neonates repaired between 2007–2020 across Sydney Children’s Hospital (SCH) and The Royal Hospital for Women (RHW). The primary outcome measure was anastomotic leakage (AL). Other outcome measures included anastomotic stricture (AS), mediastinitis, sepsis, and pneumothorax.
Results:
We reviewed 104 charts. No significant association was found between HFNC (p = 0.074) or CPAP (p = 0.859) use with development of AL, or any other adverse outcome. Independent risk factors for AL include anastomosis under tension and type B, OA-TOF. Delayed first oral intake significantly increased risk of mediastinitis (p = 0.006) and sepsis (p < 0.001).
Conclusion:
Our results suggest postoperative use of HFNC and/or CPAP is safe. Reducing anastomotic tension during repair of OA-TOF and introducing early oral feeding appears to be protective. Further prospective research is still needed to guide postextubation ventilation strategies in this population.
The changing of IVF clinics business: international embryo migration does not affect clinical outcome
Authors: Pellegrini Livia , De Angelis Franco , Tartaglia Silvio , Toschi Marco , Galliano Daniela , Pellicer Antonio , Cozzolino Mauro 
Published: March 2023

Abstract
Purpose: The regulated transportation of cryopreserved human embryos resulting from assisted reproduction treatments offers opportunities for patients to undergo embryo transfer in other regions/countries. However, with this new business for fertility clinics comes the concern of maintaining unaltered embryo quality to assure satisfactory clinical outcomes. The goal of this study was therefore to evaluate the efficacy of the transportation process by comparing the survival rate and competence of the transported embryos to embryos produced on-site.
Methods:This retrospective study assessed the pregnancy outcomes of 608 single frozen embryo transfers at IVI Rome (Italy) between March 2021 and March 2022. Autologous or donated oocytes that were fertilized in vitro, cultured to the blastocyst stage, and cryopreserved in IVI Rome (Group A, n=440), were compared to embryos generated in Spanish IVI clinics and transferred to IVI Rome (Group B, n=168).
Results: Groups A and B respectively showed no significant difference in embryo survival rates after thawing (N= 430/440, 97.7% vs. N=165/168, 98.21%, p=0.71), pregnancy rate (N=221/440, 50.23% vs. N=77/168, 45.83%, p=0.33), clinical pregnancy rate (N=200/440, 45.45% vs. N=62/168, 36.90%, p=0.06), and cumulative miscarriage rate (N=42/221, 19,00% vs. 22/77, 28.57%, p=0.07), even after taking into account embryos screened with preimplantation genetic testing.
Conclusion: The regulated transport of cryopreserved embryos did not affect embryo survival rate or pregnancy outcomes. Our results support the safety of embryo cryopreservation and security of rapid medical shipping services, encouraging clinics and patients to transport their embryos with no significant risk to their competence.
Valorization of olive pomace: phenolic prospecting and biological potential
Authors: Böhmer-Maas Bruna Wendt , Otero Deborah Murowaniecki , Alves Pâmela Inchauspe Corrêa , Pedra Nathalia Stark , Radünz¹ Marjana , Gandra Eliézer Ávila , Zambiazi Rui Carlos 
Published: March 2023

AbstractThe study aimed to extract the phenolic compounds present in the two-phase olive pomace, to characterize biological potential. Two extracts were prepared, one using a 40% methanol solution, at 70 ºC and 180 minutes of stirring (E1), and the other one using an 80% methanol solution, at 70 ºC and 180 minutes of stirring (E2). Individual phenolic compounds were quantified by LC-ESI-qTOF-MS. The evaluation of the antioxidant activity was performed by spectrophotometry against hydroxyl radical, nitric oxide and DPPH (2,2-difenil-1-picril-hidrazil). The antihyperglycemic effect was evaluated against the enzymes α-amylase and α-glycosidase. The antitumoral activity was evaluated by tests of MTT (Tetrazolium salt) and Sulforodamine B. The antimicrobial tests performed were done by disk diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The major phenolic compound present in both extracts was tyrosol. Both extracts showed antioxidant activity, antihyperglycemic effect and antitumor action. These extracts exerted moderate and weak antimicrobial activity.
Predictive Value of Pulmonary Involvement Score and Clinical Parameters for Severe COVID-19: A Nomogram-Based Approach in Emergency Department
Authors: Ouyang Tao , Wei Shuxing , Tang Yichen , Jia Xuejia , Chen Ying , Dong Hongmeng , Jia Xiuqin , Guo Shubin , Yang Qi 
Published: March 2023

AbstractBackground This study aims to evaluate the prognostic value of a pulmonary involvement (PI) score in COVID-19 patients, both independently and in combination with clinical and laboratory parameters, following the adjustment of the dynamic zeroing policy in China. Methods A total of 288 confirmed COVID-19 pneumonia patients (mild/moderate group, 155; severe group, 133) from the Emergence Department, Beijing Chaoyang Hospital, were enrolled in this study and allocated to the training and validation cohort. The PI score of the initial chest CT was evaluated using a semi-quantitative scoring system, and clinical and laboratory parameters were collected. Radiomics and combination predictive models were developed using the least absolute shrinkage and selection operator (LASSO) logistic regression algorithm and multivariate logistic regression. The models' performance for predicting severe COVID-19 was assessed by receiver operating characteristics curve (ROC) analysis and calibration curve. Results Compared with the mild/moderate patients, the severe patients had higher levels of C-reactive protein (CRP), D-dimer, procalcitonin (PCT), and brain natriuretic peptide (BNP), but lower blood oxygen saturation and vaccination rate (P < 0.05). The severe group had a higher incidence of consolidation, multi-lobe involvement, interlobular septal thickening, air bronchogram sign, and pleural effusion compared to the mild/moderate group (P < 0.05). Moreover, the PI total score of severe patients was 16.4 ± 3.8, significantly higher than 8.5 ± 3.8 of milder patients (P < 0.001). The developed predictive nomogram, which includes four clinical characteristics and one CT feature, exhibited good performance in predicting severe COVID-19 with an area under the ROC (AUC) of 0.98 (95% CI, 0.97-1.00) in the training dataset, and 0.97 (95% CI, 0.94-1.00) in the validation dataset. Conclusions The combination predictive model, including CT score, clinical factors, and laboratory data, shows favorable predictive efficacy for severe COVID-19, which could potentially aid clinicians in triaging emergency patients.
Perturbation and resilience of the gut microbiome up to three months after β-lactams exposure in healthy volunteers suggest an important role of endogenous β-lactamases
Authors: d'Humières Camille , Delavy Margot , Alla Laurie , Ichou Farid , gauliard Emilie , Ghozlane Amine , Levenez Florence , Galleron Nathalie , Quinquis Benoit , Pons Nicolas , Mullaert Jimmy , Bridier-Nahmias Antoine , Condamine Bénédicte , Touchon Marie , Rainteau Dominique , Lamazière Antonin , Lesnik Philippe , Ponnaiah Maharajah , Lhomme Marie , Sertour Natacha , Devente Savannah , Docquier Jean-Denis , Bougnoux Marie-Elisabeth , Tenaillon Olivier , Magnan Mélanie , Ruppe Etienne , Grall Nathalie , Duval Xavier , Ehrlich Dusko , Mentre France , Denamur erick , Rocha Eduardo P C , Chatelier Emmanuelle Le , Burdet Charles 
Published: March 2023

Abstract
Background
Antibiotics notoriously perturb the gut microbiota. We used untargeted and targeted phenotypic and genotypic approaches to study faecal samples collected up to 90 days following a 3-day course of intravenous β-lactam antibiotics in 22 healthy volunteers. We studied the changes in the bacterial, phage and fungal components of the microbiota as well as the metabolome and the β-lactamase activity of the stools. This allowed assessing their degrees of perturbation and resilience.
Results
While only two subjects had detectable concentrations of antibiotics in their faeces, suggesting important antibiotic degradation in the gut, the intravenous treatment perturbed very significantly the bacterial and phage microbiota, as well as the composition of the metabolome. In contrast, treatment impact was relatively low on the fungal microbiota. At the end of the surveillance period, we found evidence of resilience across the gut system since most components returned to a state like the initial one, even if the taxonomic composition of the bacterial microbiota changed and the dynamics of the different components over time were rarely correlated. The richness of the resistome was significantly reduced up to day 30, while a significant increase in the relative abundance of β-lactamase encoding genes was observed up to day 10, consistent with a concomitant increase in the β-lactamase activity of the microbiota. The level of β-lactamase activity at baseline was positively associated with the resilience of the metabolome content of the stools.
Conclusions
In healthy adults, antibiotics perturb all the components of the microbiota, which mostly return to its baseline state within 30 days. These data suggest an important role of endogenous β-lactamases producing anaerobes in protecting the functions of the microbiota by de-activating the antibiotics reaching the colon.
Postoperative pain management in obese patients undergoing gastric bypass surgery, Ketorolac and Morphine combination compared to Morphine administration effects: A Randomized Controlled Trial
Authors: Arefian Noormohammad , Faresani Hamidreza Azizi , Tabashi Soodeh , Safamanesh Sina , Faridi Maziar , Zandpazandi Sara , Behnaz Faranak 
Published: March 2023

Abstract
Background: Obstructive Sleep Apnea (OSA) is the most common respiratory problem in obese patients with Body Mass Index (BMI) > 30. Although narcotics are the best choice for postoperative pain management, their side effects restrict their utilization in these patients. Therefore, postoperative pain management remains a challenge in morbidly obese patients to reduce narcotic administration and prevent OSA.
Methods: 70 obese patients with BMI > 40kg/m2 and BMI > 35kg/m2 with underlying diseases such as diabetes, hypertension, renal disease, and cardiovascular diseases, with American Society of Anesthesiologists (ASA) physical status 1 and 2 were enrolled in this clinical trial. Patients who underwent elective laparoscopic Reux-en Y bypass were divided into two groups. Group K received a Patient-Controlled Analgesia (PCA) infusion of Morphine, Paracetamol, and IM Ketorolac. Group M received a PCA infusion of Morphine, and Paracetamol. Patients’ pain scores were recorded using a visual analog scale (VAS) immediately after the surgery, 6, 12, 24 hours later, and upon discharge.
Results: 64 patients completed the study. Pain scores decreased after the surgery, 6, 12, 24 hours later, and at the time of discharge (5.009±1.7, 3.191±2.21, 2.731±2.82, 2.106±1.48, 1.431±1.25, p<0.001) the mean of the pain score in the group K was significantly different from the group M which received Morphine, at all checkpoints ( 1.7 ± 0.34, p < 0.001).
Conclusion: Ketorolac added to the Morphine infusion pump was more effective than the morphine regime in reducing postoperative pain in obese patients.
Growth of single-crystal imine-linked covalent organic frameworks in water using amphiphilic amino-acid derivatives
Authors: Zhou Zhipeng , Zhang Lei , Yang Yonghang , Vitorica-Yrezabal Iñigo J. , Wang Honglei , Tan Fanglin , Gong Li , Li Yuyao , Chen Pohua , Dong Xin , Liang Zihao , Yang Jing , Wang Chao , Hong Yuexian , Qiu Yi , Gölzhäuser Armin , Chen Xudong , Qi Haoyuan , Yang Sihai , Liu Wei , Sun Junliang , Zheng Zhikun 
Published: March 2023

Abstract
Living organisms explored functional biomolecules such as proteins bearing glycine to create single-crystals of minerals in water without resorting to low levels of supersaturation. However, this strategy remains poorly effective in the crystallization of organic polymers. Here, we report a biomimetic strategy and its implementation to synthesize single-crystals of an important class of organic polymers - covalent organic frameworks (COFs) in water under ambient conditions. The strategy explores assemblies of amphiphilic molecules of glycine derivatives as dynamic barriers to separate monomers in water and oil phases, thereby regulating the polymerization and crystallization processes. Monomers first polymerized into disordered solids regardless of concentration variations over five orders of magnitude, then transformed into crystals in a step-by-step fashion with monomers and dimers as main building units, affording six types of single-crystals at the gram-scale with yields of ≥ 92% besides a two-dimensional COF-366. This study will be a valuable addition to the repertoire of crystallization path and methodology of organic polymers and promote their industrial applications.
Enrichment of precious metals associated with chalcopyrite inclusions in sphalerite and pyrite
Authors: Zhang He , Qian Gujie , Zhou Fengfang , Cai Yuanfeng , Pring Allan 
Published: March 2023

Abstract
The results of investigations into enrichment of precious metals in sphalerite and pyrite from the Maluntou epithermal gold deposit, China, are reported. The obtained data suggest intimate associations of Au- and Ag-bearing nanoparticles with chalcopyrite inclusions in sphalerite and pyrite. The origins of chalcopyrite inclusions involved different hydrothermal processes, including recrystallization-driven phase separation from parent chalcopyrite-sphalerite solid solutions and replacement of pre-existing pyrite in the presence of Cu-bearing fluids. The chalcopyrite blebs/lamellae follow sphalerite {111} planes, which define a shared sulfur layer for both chalcopyrite and sphalerite. This study indicates that mixing and boiling during the evolution of ore-forming fluids for the Maluntou deposit are key processes for the abnormal enrichment of precious metals in sphalerite and pyrite. The chalcopyrite micro/nano inclusions enhanced enrichment of precious metals in sphalerite provides new insights into the controls on the enrichment of precious metals in sulfides.
Constructing the Image of Feminism in Russian Media: A Corpus Study
Authors: Erofeeva E. V. , Obukhova I. A. 
Published: March 2023

As any social movement, feminism finds its reflection in the media. Media are a full-fledged institution capable of shaping public consciousness, targeting particular social groups, setting standards of mass behavior, and determining the main directions of social development. This research featured Russian news about feminism in terms of event structure. It covered news headlines published in Russian media in 2014-2021 and retrieved via the Smi2.ru media aggregator. Feminism-related headlines were automatically extracted from a dataset of 8,954 headlines. The subcorpus was analyzed in the Semograph Information System, which made it possible to classify texts, obtain frequency data on certain classes, and establish connections between them. The frequency data analysis was represented as a graphical model of the news space in the field of feminism using the SciVi visualizer. The event and thematic analyses revealed a three-level classification. The media usually informed about events where participants belonged to various social groups that protested against something, e.g., people or performances. The news informed about the actions and reactions of media people and about art sphere. The article introduces a graphical model that shows the links between event components in the headlines. It demonstrated three main areas of action in the field of feminism: art, media, and feminist movements. Each of these fields has its own core and structure. The media sphere appeared to be closed on itself; the art-related news agenda focused mostly on social matters; the field of feminist movements was associated with counteracting and involved descriptions of radical actions. When informing about feminism, the media construct an alternative reality that differs from the real issues that feminism aims at resolving.