bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Aligning Non-Order-Associated Binary Decision Diagrams
Authors: Bochkarev Alexey A. , Smith J. Cole 
Published: April 2023

Recent studies employ collections of binary decision diagrams (BDDs) to solve combinatorial optimization problems. This paper focuses on the problem of optimally aligning two BDDs, that is, transforming them to enforce a common order of variables while keeping the total size of the diagrams as small as possible. We address this problem, which is known to be NP-hard, by introducing and studying a simplified problem instead of working with the more complex original diagrams. We discuss some basic properties of the simplified problem, design a corresponding heuristic for the original problem, and show empirically that this approach yields good quality alignments while significantly reducing the complexity of intermediate diagram transformations. We highlight the practicality of this approach in the context of a variation of the uncapacitated facility location problem. History: Accepted by Andrea Lodi, Area Editor for Design and Analysis of Algorithms–Discrete. Funding: This work was supported by the Office of Naval Research [Grant N00014-17-1-2421]. Supplemental Material: The online appendices are available at https://doi.org/10.1287/ijoc.2023.1293 .
When Liability Is Not Enough: Regulating Bonus Payments in Markets with Advice
Authors: Honda Jun , Inderst Roman , Ottaviani Marco 
Published: April 2023

We introduce a model of advice in which firms steer advisors through nonlinear incentive schemes. In addition to developing an isomorphism to pricing with mixed bundling, we obtain three main insights. First, firms optimally use nonlinear bonuses to economize on the rent paid to advisors. Second, equilibrium bonus payments induce advisors to make biased recommendations that are artificially contingent on each other, resulting in an inefficient allocation. Third, if advisor liability is stepped up, firms respond by increasing the size of the bonus, leaving advisor bias unchanged. These results shed light on prevailing compensation practices for advisors and support direct regulatory interference. This paper was accepted by Joshua Gans, business strategy.
O PERFIL E A EVASÃO DAS AULAS DE EDUCAÇÃO FÍSICA NA PERSPECTIVA DOS ALUNOS DO ENSINO MÉDIO
Authors: Maffei Willer Soares , Dos Reis Gleyce Soares , Verardi Carlos Eduardo Lopes 
Published: April 2023

Tem como objetivo compreender o perfil e o nível de participação dos alunos do 3° ano do Ensino Médio nas aulas de Educação Física. Participaram do estudo 517 alunos de oito escolas públicas estaduais de um município do interior paulista. Para coleta de informações foi aplicado questionário com questões abertas e fechadas. Os resultados foram analisados por meio de estatística descritiva e análise de conteúdo e indicam atividades livres como núcleo central das aulas e experiências com o saber fazer e o saber sobre esse fazer, esses com menor destaque. Motivações pessoais e pedagógicas foram apontadas como causas para a evasão. Considera-se como urgente, perceber que, em momentos de crise e mudança, a educação física só se justificará na escola se tratar efetivamente de um saber específico que não pode ser menosprezado ou descaracterizado, de outra forma, corre o risco de ser excluída desse nível de ensino, conforme projeto em curso.
As irmãs – ou seriam amigas? – de Shakespeare: descobrindo e lendo mulheres escritoras da modernidade nascente inglesa
Authors: Thosi Aline Fernandes 
Published: April 2023

Em um de seus ensaios feministas entitulado Um teto todo seu (1929), Virginia Woolf (1882-1941) questiona a aparente ausência de mulheres escritoras no Renascimento inglês. A indagação de Woolf é pertinente, uma vez que a literatura masculina era, irrefutavelmente, dominante na modernidade nascente. O presente artigo propõe um retorno à era do Bardo – de mãos dadas com Woolf – para que seja feita uma investigação sobre as possíveis autoras inglesas contemporâneas de Shakespeare. A partir dessa investigação, um breve panorama do contexto histórico e do cenário literário feminino na Inglaterra dos séculos XVI e XVII será apresentado.
Meniscus cell lysate induces mitochondrial dysfunction of fibroblast-like synoviocytes via upregulating ANT3 in osteoarthritis
Authors: Du Xue , Jiang Zongrui , Fang Guibin , Liu Ruonan , Wen Xingzhao , Wu Yinjuan , Hu Shu , Zhang Zhiqi 
Published: April 2023

AimsThis study aimed to investigate the role and mechanism of meniscal cell lysate (MCL) in fibroblast-like synoviocytes (FLSs) and osteoarthritis (OA).MethodsMeniscus and synovial tissue were collected from 14 patients with and without OA. MCL and FLS proteins were extracted and analyzed by liquid chromatography‒mass spectrometry (LC‒MS). The roles of MCL and adenine nucleotide translocase 3 (ANT3) in FLSs were examined by enzyme-linked immunosorbent assay (ELISA), flow cytometry, immunofluorescence, and transmission electron microscopy. Histological analysis was performed to determine ANT3 expression levels in a male mouse model.ResultsWe discovered for the first time that MCL was substantially enriched in the synovial fluid of OA patients and promoted the release of inflammatory cytokines from FLSs through MCL phagocytosis. Through LC‒MS, ANT3 was identified and determined to be significantly upregulated in MCL and OA-FLSs, corresponding to impaired mitochondrial function and cell viability in OA-FLSs. Mitochondrial homeostasis was restored by ANT3 suppression, thereby alleviating synovial inflammation. Furthermore, elevated ANT3 levels inhibited ERK phosphorylation. Specifically, silencing ANT3 prevented inhibition of ERK phosphorylation and significantly reduced the elevation of reactive oxygen species (ROS) and JC1 membrane potential in MCL-induced synovial inflammation.ConclusionThis study revealed the important roles of MCL and ANT3 in FLS mitochondria. Silencing ANT3 rescued ERK phosphorylation, thereby restoring mitochondrial homeostasis in FLSs and alleviating synovitis and OA development, offering a potential target for treating synovitis and preventing early-stage OA.Cite this article: Bone Joint Res 2023;12(4):274–284.
Building bridges in place of barriers between school practitioners and researchers: on the role of embedded intermediaries in promoting evidence-based policy
Authors: Brants Hagit Sabo , Ariel Barak 
Published: April 2023

Background:
The literature on evidence-based policy in education offers insight into the need to form partnerships between researchers and practitioners with particular attention to the role of intermediaries. However, the operationalisation of the partnership, especially in school violence prevention, the focal policy of this research, remains unclear.
Objectives:
To identify potential intermediaries and explore their role in forming an evidence-based school violence prevention policy.
Method:
In-depth interviews with headteachers and members of school executive teams in Israel.
Findings:
The participants discussed three types of possible intermediaries that could facilitate a relationship between researchers and practitioners – internal inspectors, school counsellors, and external academics.
Discussion and conclusions:
We concluded that embedded intermediaries are needed to form a bridge between practice and research in the area of school violence prevention. These embedded intermediaries ought to have expertise in research methods, as well as expertise in an educational subject matter, and must be committed to the scientific approach rather than to political or organisational agendas. The formation of the research partnership must be inclusive and marked by the involvement of middle-rank policymakers (for example, headteachers) in the selection of the research questions and methodology and in the implementation of policy implications. Otherwise, evidence-based policy is unlikely to take root.
Constant envelope OFDM transmission over metro-regional optical links
Authors: Santos Caio M. , Marciano Pablo R. N. , Pontes Maria J. , Segatto Marcello E. V. , Silva Jair A. Lima 
Published: April 2023

The transmission of constant envelope orthogonal frequency division multiplexing (CE-OFDM) signals is experimentally demonstrated in this paper to increase the reach of metro-regional optical links. A recirculating fiber loop was implemented for this aim. A reach extension of 100 km of standard single-mode fiber was achieved with the CE-OFDM-based system, considering 16 quadrature amplitude modulation (16-QAM) as subcarrier mapping and links without optical dispersion compensation. Link lengths as long as 700 km, with spectral efficiency of 1.89 b/s/Hz, were accomplished with performances below the forward error correction limit.
All-dielectric metasurface based ultranarrow bandpass filter in optical C-band
Authors: Bhowmik Bhairov Kumar , Bhowmik Tanmay , Pandey Pranav Kumar , Raju Makaraju Srinivasa , Sikdar Debabrata , Kumar Gagan 
Published: April 2023

Metasurface-based nanophotonics devices can potentially replace traditional bulky optical components such as optical filters, modulators, and switches. In this study, we report a dielectric metasurface-based ultranarrow bandpass filter operating at 1549.8 nm with the ability to tune the central wavelength within the C-band. The proposed tunable filter consists of a 2D periodic array of gallium arsenide blocks placed on top of a quartz substrate. The introduction of a symmetry-breaking defect results in an ultranarrow resonance with an FWHM of 0.31 nm at a 1549.8 nm wavelength when a TE-polarized wave is normally incident. The sharp, high Q factor resonance is understood to be governed by the symmetry-protected bound state in the continuum. The resonant response can be tuned by changing the periodicity, thickness, and asymmetry of the metasurface constituents. The multipolar analysis indicates the excitation of the electric quadrupole mode at the resonance wavelength. Our findings can be useful for the design of compact tunable ultranarrow bandpass filters for optical communications systems.
Investigating public behavior with artificial intelligence-assisted detection of face mask wearing during the COVID-19 pandemic
Authors: Seresirikachorn Kasem , Ruamviboonsuk Paisan , Soonthornworasiri Ngamphol , Singhanetr Panisa , Prakayaphun Titipakorn , Kaothanthong Natsuda , Somwangthanaroj Surapoom , Theeramunkong Thanaruk 
Published: April 2023

Objectives
Face masks are low-cost, but effective in preventing transmission of COVID-19. To visualize public’s practice of protection during the outbreak, we reported the rate of face mask wearing using artificial intelligence-assisted face mask detector, AiMASK.

Methods
After validation, AiMASK collected data from 32 districts in Bangkok. We analyzed the association between factors affecting the unprotected group (incorrect or non-mask wearing) using univariate logistic regression analysis.

Results
AiMASK was validated before data collection with accuracy of 97.83% and 91% during internal and external validation, respectively. AiMASK detected a total of 1,124,524 people. The unprotected group consisted of 2.06% of incorrect mask-wearing group and 1.96% of non-mask wearing group. Moderate negative correlation was found between the number of COVID-19 patients and the proportion of unprotected people (r = -0.507, p<0.001). People were 1.15 times more likely to be unprotected during the holidays and in the evening, than on working days and in the morning (OR = 1.15, 95% CI 1.13–1.17, p<0.001).

Conclusions
AiMASK was as effective as human graders in detecting face mask wearing. The prevailing number of COVID-19 infections affected people’s mask-wearing behavior. Higher tendencies towards no protection were found in the evenings, during holidays, and in city centers.
Association between watching wide show as a reliable COVID-19 information source and preventive behaviors: A nationwide survey in Japan
Authors: Kuwahara Keisuke , Kato Mio , Ishikawa Hirono , Shinozaki Tomohiro , Tabuchi Takahiro 
Published: April 2023

Introduction
Current pandemic prompted a surge in the television (TV) news watching. However, its influence is poorly understood. In Japan, wide show, a major genre of soft news TV programs, broadcasted COVID-19 for long hours, and was pointed out that it broadcasted COVID-19 sensationally, arousing fear and anxiety, and that it criticized individuals gathering in closed places. Thus, wide show may promote preventive behaviors but also produce fear or anxiety and aggressiveness towards others not engaging in preventive behaviors. We examined this issue using large-scale nationwide data.

Methods
We analyzed the cross-sectional data of 25,482 individuals from the Japan COVID-19 and Society Internet Survey conducted in 2020. Participants reported the type of COVID-19 information sources including TV news and wide show, and their trustworthiness. We calculated multivariable-adjusted prevalence ratios (PRs) of engaging in recommended preventive behaviors strictly (defined as always engaging in hand washing, mask wearing, and attempting to keep physical distancing) and alerting others not engaging in preventive behaviors, respectively.

Results
About 72.4% of the participants obtained information from TV news with reliance, while corresponding values were 50.3% for wide show. Overall, 32.8% engaged in recommended preventive behaviors strictly, and 9.6% alerted others. Watching wide show both with and without reliance were significantly associated with alerting others (adjusted PRs: 1.48 and 1.34, respectively) but not associated with preventive behaviors. Watching TV news was neither associated with strict preventive behaviors nor alerting others.

Conclusion
Watching TV news and wide show was not associated with strict preventive behaviors; watching wide show was associated with only alerting others. Although causality is unclear, actions may be needed for TV stations broadcasting wide show to understand own influences on society in a timely manner amid the health emergencies.
Calcitriol modifies tight junctions, improves barrier function, and reduces TNF‐α‐induced barrier leak in the human lung‐derived epithelial cell culture model, 16HBE 14o‐
Authors: Rybakovsky Elizabeth , DiGuilio Katherine M. , Valenzano Mary Carmen , Geagan Sophie , Pham Kaithlyn , Harty Ronald N. , Mullin James M. 
Published: April 2023

AbstractUsing the 16HBE 14o‐ human airway epithelial cell culture model, calcitriol (Vitamin D) was shown to improve barrier function by two independent metrics – increased transepithelial electrical resistance (TER) and reduced transepithelial diffusion of 14C‐D‐mannitol (Jm). Both effects were concentration dependent and active out to 168 h post‐treatment. Barrier improvement associated with changes in the abundance of specific tight junctional (TJ) proteins in detergent‐soluble fractions, most notably decreased claudin‐2. TNF‐α‐induced compromise of barrier function could be attenuated by calcitriol with a concentration dependence similar to that observed for improvement of control barrier function. TNF‐α‐induced increases in claudin‐2 were partially reversed by calcitriol. The ERK 1,2 inhibitor, U0126, itself improved 16HBE barrier function indicating MAPK pathway regulation of 16HBE barrier function. Calcitriol's action was additive to the effect of U0126 in reducing TNF‐ α ‐induced barrier compromise, suggesting that calcitriol may be acting through a non‐ERK pathway in its blunting of TNF‐ α – induced barrier compromise. This was supported by calcitriol being without effect on pERK levels elevated by the action of TNF‐α. Lack of effect of TNF‐ α on the death marker, caspase‐3, and the inability of calcitriol to decrease the elevated LC3B II level caused by TNF‐α, suggest that calcitriol's barrier improvement does not involve a cell death pathway. Calcitriol's improvement of control barrier function was not additive to barrier improvement induced by retinoic acid (Vitamin A). Calcitriol improvement and protection of airway barrier function could in part explain Vitamin D's reported clinical efficacy in COVID‐19 and other airway diseases.
Neonatal exposure to hypoxia induces early arterial stiffening via activation of lysyl oxidases
Authors: Steppan Jochen , Nandakumar Kavitha , Wang Huilei , Jang Rosie , Smith Logan , Kang Sara , Savage William , Bauer Maria , Choi Rira , Brady Travis , Wodu Bulouere Princess , Scafidi Susanna , Scafidi Joseph , Santhanam Lakshmi 
Published: April 2023

AbstractHypoxia in the neonatal period is associated with early manifestations of adverse cardiovascular health in adulthood including higher risk of hypertension and atherosclerosis. We hypothesize that this occurs due to activation of lysyl oxidases (LOXs) and the remodeling of the large conduit vessels, leading to early arterial stiffening. Newborn C57Bl/6 mice were exposed to hypoxia (FiO2 = 11.5%) from postnatal day 1 (P1) to postnatal day 11 (P11), followed by resumption of normoxia. Controls were maintained in normoxia. Using in vivo (pulse wave velocity; PWV) and ex vivo (tensile testing) arterial stiffness indexes, we determined that mice exposed to neonatal hypoxia had significantly higher arterial stiffness compared with normoxia controls by young adulthood (P60), and it increased further by P120. Echocardiography performed at P60 showed that mice exposed to hypoxia displayed a compensated dilated cardiomyopathy. Western blotting revelated that neonatal hypoxia accelerated age‐related increase in LOXL2 protein expression in the aorta and elevated LOXL2 expression in the PA at P11 with a delayed decay toward normoxic controls. In the heart and lung, gene and protein expression of LOX/LOXL2 were upregulated at P11, with a delayed decay when compared to normoxic controls. Neonatal hypoxia results in a significant increase in arterial stiffness in early adulthood due to aberrant LOX/LOXL2 expression. This suggests an acceleration in the mechanical decline of the cardiovascular system, that contributes to increased risk of hypertension in young adults exposed to neonatal hypoxia that may increase susceptibility to further insults.
The Wigner transformation associated with the Hankel multidimensional operator
Authors: Amri Besma 
Published: April 2023

Abstract
We consider the Hankel multidimensional operator

Δ
α

\Delta_{\alpha}

,

α
=

(

α
1

,
…
,

α
n

)

∈

]

−

1
2

,

+
∞

[

n

\alpha=(\alpha_{1},\dots,\alpha_{n})\in\mathopen{]}-\frac{1}{2},+\infty\mathclose{[}^{n}

, defined on

]
0
,

+
∞

[

n

\mathopen{]}0,+\infty\mathclose{[}^{n}

by

Δ
α

=

∑

j
=
1

n

(

∂
2

∂

x
j
2

+

2
⁢

α
j

+
1

x
j

⁢

∂

∂

x
j

)

.

\Delta_{\alpha}=\sum_{j=1}^{n}\biggl{(}\frac{\partial^{2}}{\partial x_{j}^{2}}+\frac{2\alpha_{j}+1}{x_{j}}\frac{\partial}{\partial x_{j}}\biggr{)}.

We define and study the Wigner transformation

V
g

\mathscr{V}_{g}

(called also Gabor transform), where

g
∈

L
2

⁢

(

d
⁢

μ
α

)

g\in L^{2}(d\mu_{\alpha})

and

d
⁢

μ
α

d\mu_{\alpha}

is the measure defined on

[
0
,

+
∞

[

n

[0,+\infty\mathclose{[}^{n}

by

d
⁢

μ
α

⁢

(
x
)

=

⨂

j
=
1

n

x
j

2
⁢

α
j

+
1

2

α
j

⁢
Γ
⁢

(

α
j

+
1

)

⁢
d
⁢

x
j

.

d\mu_{\alpha}(x)=\bigotimes_{j=1}^{n}\frac{x_{j}^{2\alpha_{j}+1}}{2^{\alpha_{j}}\Gamma(\alpha_{j}+1)}\,dx_{j}.

Using harmonic analysis related to the Hankel operator

Δ
α

\Delta_{\alpha}

, we prove a Plancherel theorem and an orthogonality property for the transformation

V
g

\mathscr{V}_{g}

.
Next, we establish a reconstruction formula for

V
g

\mathscr{V}_{g}

and give some applications.
In the second part of this work, as applications of the Wigner transformation

V
g

\mathscr{V}_{g}

, we define and study the anti-Wick operators

A

g
1

,

g
2

⁢

(
σ
)

\mathscr{A}_{g_{1},g_{2}}(\sigma)

, where

g
1

,

g
2

∈

L
2

⁢

(

d
⁢

μ
α

)

g_{1},g_{2}\in L^{2}(d\mu_{\alpha})

are called window functions and

σ
∈

L
p

⁢

(

d
⁢

μ
α

⊗
d

⁢

μ
α

)

\sigma\in L^{p}(d\mu_{\alpha}\otimes d\mu_{\alpha})

is a signal.
Building on the properties of the Wigner transformation

V
g

\mathscr{V}_{g}

, we prove that the operators

A

g
1

,

g
2

⁢

(
σ
)

\mathscr{A}_{g_{1},g_{2}}(\sigma)

are bounded linear operators and compact on the Hilbert space

L
2

⁢

(

d
⁢

μ
α

)

L^{2}(d\mu_{\alpha})

.
Finally, we establish a formula of the trace for the anti-Wick operator

A

g
1

,

g
2

⁢

(
σ
)

\mathscr{A}_{g_{1},g_{2}}(\sigma)

when the signal 𝜎 belongs to

L
1

⁢

(

d
⁢

μ
α

⊗
d

⁢

μ
α

)

L^{1}(d\mu_{\alpha}\otimes d\mu_{\alpha})

.
The role of Bruton’s kinase inhibitors (BTKi) in accelerated Chronic Lymphocytic Leukemia (a-CLL): a case of successful response to acalabrutinib
Authors: Catania Gioacchino , Tavarozzi Rita , Pini Giacomo Maria , Borra Tiziana , Gandolfo Carolina , Zacchi Giulia , Pietrasanta Daniela , Monaco Federico , Zanni Manuela , Lettieri Maddalena , Rivela Paolo , Zallio Francesco , Ladetto Marco 
Published: April 2023

Abstract

Objectives
The use of Bruton’s tyrosine kinase (BTK) inhibitors has changed the clinical history of patients with chronic lymphocytic leukemia (CLL) in both naïve and relapsed/refractory settings. “Accelerated” chronic lymphocytic leukemia (a-CLL) is a relatively rare form of CLL representing less than 1 % of all CLL cases. a-CLL patients usually have a more aggressive course and a reduced overall survival was reported with conventional chemo-immunotherapy approaches.

Methods
The role of Bruton Tyrosine Kinase-inhibitor, ibrutinib, in a-CLL is well established with encouraging preliminary results.

Results
We report a case of a-CLL-treated first-line with second-generation BTKi, acalabrutinib with a prompt clinical response. As known, it is the first literature report on acalabrutinib in a-CLL highlighting the role of second-generation BTKi also in this high-risk setting.

Conclusions
Target therapies (Bruton Kinase inhibitors and Bcl2 inhibitors) have improved the therapeutic landscape of CLL. The availability of therapeutic targets requires greater diagnostic accuracy to choose the most appropriate therapy for each patient.
Digging deep: hoary marmots (Marmota caligata) use refuge burrows excavated by grizzly bears (Ursus arctos)
Authors: Jung Thomas S. , Arnold Sarah M. , Heathcote Alexandra L. , Kukka Piia M. , Willier Caitlin N. , McCulley Alice M. , Stotyn Shannon A. , Wilcox Kirsten A. 
Published: April 2023

Abstract
Hoary marmots (Marmota caligata) dig burrows in alpine meadows rich in forage as ready refuge from potential predators. Refuge burrows enable hoary marmots to engage in risk-sensitive foraging when they are away from more secure resting burrows on talus slopes. Grizzly bears (Ursus arctos) commonly excavate refuge burrows while hunting marmots, substantially changing the physical characteristics of the burrow by removing earthen material. However, it is not known if marmots continue to use excavated burrows as refuge. We opportunistically inspected 22 burrows excavated by grizzly bears for use by marmots at two sites in northwestern Canada. We found marmot feces at 10 of 22 excavated burrows, indicating that marmots continued to use these burrows after they were excavated by bears. While marmots may dig several refuge burrows in alpine meadows, and bears may substantially modify them while hunting marmots, our observations indicate that some excavated burrows retain value for foraging marmots. However, the extent of their utility is unknown. We postulate several reasons why hoary marmots may use excavated burrows and suggest avenues for further research.