bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mycoprotein as chicken meat substitute in nugget formulation: Physicochemical and sensorial characterization
Authors: Hashempour‐Baltork Fataneh , Jannat Behrooz , Dadgarnejad Manouchehr , Mirza Alizadeh Adel , Khosravi‐Darani Kianoush , Hosseini Hedayat 
Published: April 2023

AbstractThe aim of this study was to replace chicken breast by mycoprotein in nuggets and optimizing the sensory and technological properties. In the first step of the study, 14 formulations were prepared by mixture design to evaluate the impact of three binding agents (as independent variables): soy protein isolate, phosphate, and carrageenan on sensory properties. Then, the optimized formulation of mycoprotein nugget (with higher acceptability) was characterized and compared to chicken nugget (control) from texture, color, and physicochemical aspects. The texture attributes including hardness, springiness, cohesiveness, and chewiness of the optimized sample (1.37 kg, 0.70 mm, 0.56, and 0.53 kg.mm) had no significant difference (p > .05) compared to control. Based on the results, optimized sample had a lower lightness and yellowness (a*, b*, and L* were 3.06, 18.62, and 59.23, respectively) rather than the similar value of the control (2.20, 21.27, and 79.10, respectively), which indicated carrageenan did not lead to any significant impact (p > .05) on the color. Also, mycoprotein nugget showed 33% lower cooking loss in comparison to control. Moisture, protein, lipid, and ash in optimized sample were 57.9 ± 1.9, 24.1 ± 1.0, 13.2 ± 1.2, and 2.1 ± 0.5, respectively. Investigation on physicochemical properties shows an acceptable characterization in optimized sample in comparison to control. The results of this study present an opportunity to produce nonmeat nuggets with similar texture and acceptable sensory and technological characteristics by using mycoprotein as meat alternative. The production of mycoprotein is eco‐friendly, not dependent on climate (flood and drought) and landscape limitation, which is an important aspect in meat alternatives in the near future.
Has Iran achieved the goal of reducing the prevalence of households faced with catastrophic health expenditure to 1%?: A national survey
Authors: Shokri Azad , Bolbanabad Amjad Mohamadi , Rezaei Satar , Moradi Ghobad , Piroozi Bakhtiar 
Published: April 2023

AbstractBackground and AimsOne of the goals of the Islamic Republic of Iran is to reduce the prevalence of catastrophic health expenditures among Iranian households to 1% by the end of the sixth 5‐year development plan (2016−2021). This study was conducted to evaluate the level of access to this goal in the final year of this program.MethodsA national cross‐sectional study was conducted on 2000 Iranian households in five provinces of Iran in 2021. Data were collected through interviews using the World Health Survey questionnaire. Data from households whose health care costs were more than 40% of their capacity to pay were included in the group of households with catastrophic health expanditure (CHE). Determinants of CHE were identified using univariate and multivariate regression analysis.Results8.3% of households had experienced CHE. The variables of being a female head of household (odd ratio [OR] = 2.7), use of inpatient (OR = 1.82), dental (OR = 3.09), and rehabilitation services (OR = 6.12), families with disabled members (OR = 2.03) and low economic status of the households (OR = 10.73) were significantly associated with increased odds of facing CHE (p < 0.05).ConclusionIn the final year of the sixth 5‐year development plan, Iran has not yet achieved its goal of “reducing the percentage of households exposed to CHE to 1%.” Policymakers should pay attention to factors increasing the odds of facing CHE in designing interventions.
Public health concerns about Tuberculosis caused by Russia/Ukraine conflict
Authors: Paul Innocent K. , Nchasi Goodluck , Bulimbe Deusdedith B. , Mollel Meshack K. , Msafiri George G. , Mbogo Alex , Mswanzari Mayunga B. , Joseph Msengi , Mahmoud Ashraf , Volkova Anastasiia 
Published: April 2023

AbstractAccording to WHO, Ukraine has the fourth‐highest Tuberculosis (TB) incidence in the WHO European region while globally has the fifth‐highest number of confirmed cases of extensively drug‐resistant TB. Before the Russian invasion in Ukraine several interventions have been employed to mitigate the TB epidemic in the country. However, the ongoing war has demolished meticulous efforts and subsequently worsen the situation. WHO in collaboration with the Ukraine government and other organizations such as EU and UK are required to take up arms against the situation. In this work, implications brought up from the war, efforts, and recommendations to battling TB epidemic due to the war are highlighted.
Technical computations for dependent shear rate effect on magnetized peristaltic transport of synovia with two fluid viscosity models: Arthritis treatments
Authors: Ibrahim M. G. , Brini S. , Sfina N. , Briki K. 
Published: April 2023

AbstractSynovitis studies are the key to the treatment of most arthritis diseases in a human physique. So this study visualizes the effects of two dependent fluid viscosity models on magnet nano peristaltic transport of synovial fluid in nonuniform channel walls. Two fluid models are constructed, the first model considered that the Shear rate is dependent on fluid concentration (model‐I), and the exponentially dependent viscosity on the fluid concentration is proposed as a second model (model‐II). The fluid models are represented by a highly nonlinear system of partial differential equations. Joule heat, thermal radiation, and Arrhenius energy are studied as external effects. Those models are offered in a gradient mechanism, then simplified using droppings bars and using the fact of long wavelength, and low Reynolds. Pressure gradient and trapped bolus profiles and shear stress distribution as well as fluid temperature, velocity, and concentration performance are scrutinized. Analytical results are obtained in appropriate/chosen boundary conditions depending on the walls of the channel. Attracted/signified results are compared with the nearest trusted results by Khan et al. Solution intervals are sub‐divided and analytically treated at each of them by multi‐stage differential transform algorithms. Outcomes gratify that, joints are provided by more cushion and lubrication at high fluid temperatures. Magnetic effects are advised in rheumatoid arthritis treatments, increasing the synovial fluid temperature and allowing fluid particles to move freely inside joints.
Role of lncRNA MAGI2‐AS3 in lipopolysaccharide‐induced nucleus pulposus cells injury by regulating miR‐374b‐5p/interleukin‐10 axis
Authors: Yu Jiang , Li Chengjin 
Published: April 2023

AbstractBackgroundIntervertebral disc degeneration (IDD) is a pathological process that occurs during the natural aging of intervertebral discs. Accumulating evidence suggests that noncoding RNAs (ncRNAs), including microRNAs and long ncRNAs (lncRNAs), participate in the pathogenesis and development of IDD. Herein, we examined the role of lncRNA MAGI2‐AS3 in the pathogenic mechanism of IDD.Material and MethodsTo develop an IDD in vitro model, we treated human nucleus pulposus (NP) cells with lipopolysaccharide (LPS). Aberrant levels of lncRNA MAGI2‐AS3, miR‐374b‐5p, interleukin (IL)‐10 and extracellular matrix (ECM)‐related proteins in NP cells were examined using reverse transcription‐quantitative PCR and western blot analysis. LPS‐induced NP cell injury and inflammatory response were confirmed using the MTT assay, flow cytometry, Caspase3 activity, and enzyme‐linked immunosorbent assay. Dual‐luciferase reporter assay and rescue experiments were performed to confirm targets between lncRNA MAGI2‐AS3 and miR‐374b‐5p or miR‐374b‐5p and IL‐10.ResultsLPS‐induced NP cells exhibited low levels of lncRNA MAGI2‐AS3 and IL‐10 expression, along with high miR‐374b‐5p expression. miR‐374b‐5p was a target of lncRNA MAGI2‐AS3 and IL‐10. LncRNA MAGI2‐AS3 ameliorated injury, inflammatory response, and ECM degradation in LPS‐treated NP cells by downregulating miR‐374b‐5p to upregulate IL‐10 expression.ConclusionsLncRNA MAGI2‐AS3 increased IL‐10 expression levels by sponging miR‐374b‐5p, which, in turn, alleviated LPS‐triggered decreased NP cell proliferation and increased apoptosis, inflammatory response, and ECM degradation. Therefore, lncRNA MAGI2‐AS3 may be a potential therapeutic target for IDD.
Magnetized vermiculite as a tool for the treatment of produced water generated by oil companies: Effects on aquatic organisms before and after treatment
Authors: Viana Tais S. , Campos Diana , Bartilotti Mariana , Leite Fernanda G. , Zanoni Maria Valnice Boldrin , Dorta Daniel J. , Oliveira Danielle P. , Pestana João L. T. 
Published: April 2023

AbstractProduced water (PW) generated by oil companies is a highly impacting waste that contains chemicals such as metals and organic and inorganic compounds. Given its polluting potential, PW requires effective treatment before being discharged into the environment. Conventional treatments have limited efficiency in removing PW toxicity, so alternative approaches must be developed and standardized. In this context, treatment with adsorbent materials like magnetized vermiculite (VMT‐mag) is highlighted. This work aimed to evaluate the efficiency of treatment with VMT‐mag in reducing PW toxicity to aquatic biota. For this purpose, three aquatic species (the midge Chironomus riparius, the planarian Girardia tigrina, and the crustacean Daphnia magna) were exposed to untreated PW and to PW treated with VMT‐mag at laboratory conditions. The assessed endpoints included mortality, growth, emergence, and developmental time of C. riparius; mortality, locomotion, feeding, and head regeneration of G. tigrina; and intrinsic population growth rate (r) and reproductive output of D. magna. The results showed that all the species exposed to raw PW were impaired: C. riparius had delayed development, G. tigrina had reduced locomotor activity and delayed head regeneration, and D. magna had reduced reproduction and delayed intrinsic population growth rate (r). Most of the analyzed parameters showed that treatment with VMT‐mag diminished PW toxicity. Therefore, using VMT‐mag to treat PW may be the key to reducing the PW effects on aquatic organisms.
Trauma‐focused treatment of a client with Complex PTSD and comorbid pathology using EMDR therapy
Authors: De Jongh A. , Hafkemeijer L. C. S. 
Published: April 2023

AbstractObjectiveComplex post‐traumatic stress disorder (CPTSD) is a classification within the International Classification of Diseases, 11th Revision (ICD‐11) that, besides the DSM‐5 symptom clusters of post‐post‐traumatic stress disorder (PTSD), includes the presence of negative self‐concept, difficulties in regulating emotions and relationship skills. The purpose of the present study was to provide guidance on how to deliver Eye Movement Desensitization and Reprocessing (EMDR) therapy in the context of CPTSD, based on current clinical knowledge and the latest scientific research findings.MethodThis paper describes the treatment of a 52‐year‐old woman with CPTSD and borderline personality disorder for which immediate trauma‐focused EMDR therapy was used.ResultsFirst, a description of what EMDR therapy entails and some important treatment strategies that the therapist may employ to assist in trauma‐focused treatment of clients with CPTSD using EMDR therapy are outlined.ConclusionThe treatment results are in line with mounting evidence supporting the notion that EMDR therapy is a safe and potentially effective treatment alternative for individuals with CPTSD or personality problems.
Utilization of three‐dimensional framework theory in identifying the motivational factors for selecting a postgraduate dental specialty–A pilot study
Authors: Zulfiqar Kanwal , Farid Huma , Luqman Uzair , Ilyas Kausar , Bashir Ulfat 
Published: April 2023

AbstractObjectivesThree‐dimensional framework theory classifies factors influencing career selection into intrinsic, extrinsic, and interpersonal dimensions. The objectives of this pilot research were to assess the psychometric properties of a scale encompassing factors affecting post‐graduation specialty selection according to three‐dimensional framework theory and identify motivational factors that affect dental students’ and interns’ choice of post‐graduation specialty.MethodologyA closed‐ended self‐structured research instrument consisting of a list of 19 factors was presented to dental students and dental interns at Margalla Dental College, Rawalpindi, Pakistan, and Islamic International Dental College, Islamabad, Pakistan (n = 235). Exploratory factor analysis and Cronbach‐alpha (α) were used to assess the construct validity and reliability (internal consistency) of the scale respectively. Descriptive analysis and non‐parametric tests were used for data analysis with a level of significance at ≤0.05.ResultsA 3‐factor solution with 11 items was stabilized. Cronbach‐alpha of the pilot study turned out to be 0.72. With a response rate of 92.15%, the most common motivational factor affecting post‐graduation specialty selection was the Intrinsic factor “personnel joy and motivation to work hard.” Dental interns and male participants were more likely to select the post‐graduation specialty due to intrinsic motivational factors (p < 0.05). Inspiration from the family member and supporting the family also influenced male participants and interns respectively (p < 0.05). Female participants preferred to choose a less saturated field (p < 0.05). A medium positive statistically significant correlation was observed between the interpersonal motivational factor “inspiration by a teacher” and the choice of “basic sciences” as a post‐graduation specialty (p < 0.01).ConclusionThis pilot study resulted in the development of a scale with a 3‐factor solution stabilized at 11 items. The internal consistency of the scale turned out to be 0.72. Oral and maxillofacial surgery was the first choice of post‐graduation chosen by 35.5% of the respondents. Fellowship was chosen as the preferred type of post‐graduation by 46% of the respondents. Irrespective of gender and designation, the top most influential factor, chosen by 88.5% of the respondents, was the intrinsic motivational factor “personal joy and motivation to work hard.”
Referral networks for pediatric patients with genetic conditions: The perspective of occupational therapists
Authors: Henly Megan , Phillips Kimberly G. , Smith Sarah L. , Kloza Edward M. , Brucker Debra L. 
Published: April 2023

AbstractFamilies of children with developmental delays but no diagnosed genetic condition may benefit from connection to genetic systems of care. This work examines the role of occupational therapy as a space for families of pediatric patients to gain access to genetic services. Between September 2021 and February 2022, we interviewed 20 occupational therapists in New England who work primarily with pediatric patients. We transcribed the interviews and used a grounded theory approach to identify and code recurring themes. The data reveal several barriers to linking pediatric patients to genetic systems of care, including lack of insurance coverage, wait times for appointments and test results, hesitant primary care providers, and familial and cultural stigma of disability. We discuss the unique role of occupational therapists as professionals who spend substantial time with patients, often in their everyday environments, to bridge these barriers. We also address challenges associated with occupational therapists facilitating connections to genetics services, including their lack of specialized knowledge of genetics and barriers fully integrating with others on the medical team.
Intraoperative Bleeding Control with Terlipressin in Functional Endoscopic Sinus Surgery
Authors: Pavlov Vladimir E. , Polushin Yury S. , Kolotilov Leonid V. , Karpishchenko Sergey A. 
Published: April 2023

ObjectiveTo evaluate the use of terlipressin for intraoperative bleeding reduction in functional endoscopic sinus surgery (FESS).MethodsThis prospective, randomized, single‐center, single‐blinded cohort study included 74 cases of FESS performed under general anesthesia (GA). The patients were randomized into two groups: WT (without terlipressin, n = 39) and T (with 200 μg terlipressin, n = 35). Bleeding intensity (BI) was assessed using a 6‐point scale. Heart rate (HR), mean blood pressure (MBP), perfusion index (PI), and BI were recorded at 10, 30, and 60 min after surgery. A BI score ≥2 qualified as significant.ResultsThe T group had significantly higher MBP compared with the WT group, but HR values did not differ significantly. PI and BI scores were significantly reduced in the T group compared with the WT group. The risk of significant bleeding in the treatment group was 35.5 times lower (odds ratio [OR], 0.028; 95% confidence interval [CI], 0.006–0.138) at 30 min and 7.1 times lower (OR, 0.140; 95% CI, 0.049–0.402) at 60 min. The prognostic model for significant bleeding at 60 min showed that only terlipressin played a significant role in bleeding control (p < 0.05). The model predicted a 13.9‐fold decrease in significant bleeding risk in the T group.ConclusionLow doses (200 μg) of terlipressin reduced intraoperative bleeding without decreasing blood pressure during FESS under GA.Level of Evidence2 Laryngoscope, 133:3313–3318, 2023
The impact of distance traveled and rurality on the clinical course of head and neck cancer
Authors: Debick Nadia , Gemmiti Amanda , Ryan Jesse 
Published: April 2023

AbstractObjectiveTo explore the relationship between distance traveled and rurality to clinical timepoints and 2‐year disease free survival (DFS) in newly diagnosed HNC patients.MethodsThis study was conducted through retrospective analysis, with key independent variables including distance to academic medical center and rurality score. To better understand delays in care, the sample was divided into two groups based on an optimal treatment timeline. We then assessed for the impact of distance traveled.ResultsA higher proportion of patients in the optimal treatment timeline group resided in metropolitan areas, which also had a lower mean index of medically underserviced score. Patients in this group had a shorter duration from first presentation for HNC to presentation to an academic medical center and a shorter duration from referral to presentation. However, there was no significant difference in 2‐year DFS between the groups. Those who lived closest to Upstate were more likely to identify as Black. Those who live in suburban communities around Upstate were most likely to initiate treatment within 1 month of presentation. Those who live farthest from Upstate were the least likely to have an HPV‐negative cancer of the head and neck, and more likely to receive surgery as part of treatment and to receive a biopsy prior to presenting to Upstate.ConclusionsDespite differences in distance traveled and rurality between communities, there was no impact on 2‐year DFS. Together, we suggest that these findings support that socioeconomic and patient factors, instead of travel distance alone, impact HNC workup patterns.Level of EvidenceLevel III.
Production of phytodetritus by a coral reef sponge increases from shallow to mesophotic depths
Authors: Lesser Michael P. , Macartney Keir J. , Slattery Marc 
Published: April 2023

AbstractOn Caribbean coral reefs, sponges are important members of the benthic community and have an important role in consuming particulate organic matter (POM) and dissolved organic matter (DOM), with the subsequent production of detritus that is then shunted into a process now referred to as the “sponge‐loop.” An emergent species of sponge commonly found on Caribbean coral reefs, Agelas tubulata, increases in size and growth rate from shallow (< 30 m) to mesophotic depths (30–150 m) on Grand Cayman Island. A. tubulata depends largely on heterotrophy across shallow to mesophotic depths and has been shown to utilize detritus on shallow reefs. However, detritus production by A. tubulata on shallow and mesophotic coral reefs has not been previously reported. Here we show, using flow cytometry, that sponge detritus includes a previously unquantified component, phytodetritus. Sponge phytodetritus production was shown experimentally to be greater in sponges from mesophotic depths compared to sponges from shallow coral reefs. Additionally, the size range of this phytodetritus corresponds to the size range of autotrophic picoplankton, primarily prochlorophytes, known to be an important food source for filter‐feeding sponges. Given the known lability of phytodetritus, compared to other more recalcitrant components of the detrital pool, its role in the food web of mesophotic communities combined with the increased availability of live POM, may be an underappreciated component of mesophotic community carbon and nitrogen flow.
Advances in Intelligent Stimuli‐Responsive Microneedle for Biomedical Applications
Authors: Xu Kai , Weng Jie , Li Jianshu , Chen Xingyu 
Published: April 2023

AbstractMicroneedles (MNs) are a new type of drug delivery method that can be regarded as an alternative to traditional transdermal drug delivery systems. Recently, MNs have attracted widespread attention for their advantages of effectiveness, safety, and painlessness. However, the functionality of traditional MNs is too monotonous and limits their application. To improve the efficiency of disease treatment and diagnosis by combining the advantages of MNs, the concept of intelligent stimulus‐responsive MNs is proposed. Intelligent stimuli‐responsive MNs can exhibit unique biomedical functions according to the internal and external environment changes. This review discusses the classification and principles of intelligent stimuli‐responsive MNs, such as magnet, temperature, light, electricity, reactive oxygen species, pH, glucose, and protein. This review also highlights examples of intelligent stimuli‐responsive MNs for biomedical applications, such as on‐demand drug delivery, tissue repair, bioimaging, detection and monitoring, and photothermal therapy. These intelligent stimuli‐responsive MNs offer the advantages of high biocompatibility, targeted therapy, selective detection, and precision treatment. Finally, the prospects and challenges for the application of intelligent stimuli‐responsive MNs are discussed.
Dimensions of Network Polymers: Universal Relationship for the Ratio between Mean‐Square Radius of Gyration and Graph Diameter
Authors: Tobita Hidetaka 
Published: April 2023

AbstractMean‐square radius of gyration Rg2 and the graph diameter D, which describe the dimensions of polymers, are investigated for the network polymers. Both for the random and nonrandom statistical networks whose cycle rank is r, a linear relationship Rg2 = ar D applies. The ratio ϕ of ar against the corresponding ring‐free architecture a0, ϕr = ar/a0 has a universal relationship applicable both for the random and nonrandom networks with ϕr∝r−0.25 for large r’s, and an empirical relationship, ϕr = [(1 + r)−2/3 + r/2]−0.25 is proposed. For the polymer fraction having a given number of r, the nonrandom nature of crosslinking tends to make both Rg2 and D larger compared with the corresponding random networks, except for the limited cases with small values of r’s.