bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do older adults respond to cognitive behavioral therapy as well as younger adults? An analysis of a large, multi‐diagnostic, real‐world sample
Authors: Pomerleau Vincent Jetté , Sekhon Harmehr , Bajsarowicz Paulina , Demoustier Arnaud , Rej Soham , Myhr Gail 
Published: June 2023

AbstractObjectivesOlder adults (OA; ≥55 years of age) are underrepresented in patients receiving cognitive‐behavioral therapy (CBT). This study evaluates mental health outcomes for OA compared to younger adults (YA; <55 years of age) receiving CBT.DesignThis is a pre‐post study comparing the effectiveness of CBT for OA (n = 99) and YA (n = 601) in a CBT service located in a university‐affiliated tertiary care hospital in Canada. Data was collected between 2001 and 2021. Participants received a mean of 18.5 sessions (SD 10) of standard, evidence‐based CBT with treatment integrity checks. The main outcome was clinically significant change, as measured by the Reliable Change Index (RCI). Secondary outcomes were change in the Global Severity Index (GSI‐SCL) of the Symptoms Checklist‐90 (Revised), and Clinical Global Improvement scores (CGI).ResultsThe RCI allowed a comparison of treatment efficacy across diagnoses. Both groups experienced similar improvement on the RCI (2.92 [±3.64] vs. 3.15 [±4.86], p = 0.65). Furthermore, 39% of OA and 42% of YA no longer met criteria for their diagnoses. Groups did not differ with respect to changes in the GSI‐SCL. The CGI severity comparison suggested that OA had milder illness. In all outcomes (RCI, CGI and GSI‐SCL), participants improved over time.ConclusionsThis real‐world study analyzed a large sample of OA and YA undergoing CBT for various mental health conditions. Both groups were found to benefit equally.
Association of subjective cognitive complaints with poor sleep quality: A cross‐sectional study among Chinese elderly
Authors: Hu Qing , Song Yinhua , Wang Shibin , Lin Lihua , Ke Yunfei , Zhang Ping 
Published: June 2023

AbstractObjectivesSubjective cognitive complaints (SCC) are the earliest symptom of Alzheimer's disease (AD) progression. Increasing evidence shows an association between poor sleep quality and SCC, but the current conclusions regarding the association between poor sleep quality and SCC in older adults are contradictory. Here, we aimed to explore the correlation of SCC with poor sleep quality among older adults without dementia living in nursing home and community in China.MethodsA cross‐sectional survey on sleep and psychosomatic health of older adults was conducted in Guangdong, China, between November 2020 and March 2021. Socio‐demographic, health‐related information, psychological factors, sleep quality and SCC of participants were evaluated through a face‐to‐face interview. A 9‐item Subjective Cognitive Decline Questionnaire (SCD‐Q9) was used to measure SCC; SCD‐Q9 > 3 was defined as SCC. The Chinese version of the Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality; PSQI > 7 was defined as poor sleep quality. The relationship between SCC and sleep quality was evaluated using logistics regression analysis.ResultsThe study involved 730 participants (mean age 74.14 ± 8.246 years). The total SCC prevalence was 59.59%. The SCC group had poor sleep quality than the reference group (p < 0.05). Adjusted multiple logistic regression analysis revealed an association of poor sleep quality with SCC (OR = 1.841; 95% CI, 1.267–2.647; p = 0.001) after controlling for age, sex, residence, education level, marital status, income, smoking, alcohol consumption, tea drinking, multimorbidity, waist circumference, napping duration, anxiety symptoms, and depression symptoms. Hierarchical logistics regression analysis showed an association between sleep quality and SCC among community older adults (OR = 2.872; 95% CI: 1.787–4.615; p < 0.001), but not in nursing home residents (OR = 0.845; 95% CI: 0.437–1.637; p = 0.619).ConclusionsPoor sleep quality is associated with SCC in community older adults. Therefore, medical staff should take measures, such as earlier cognitive intervention, to postpone cognitive decline in older adults, in the meantime, earlier management and treatment of sleep disorders should be taken into consideration.
Prediction of complications of pre‐eclampsia using the fullPIERS high risk predictive model
Authors: Sharma Astha , Suri Jyotsna , Khanam Zeba , Pandey Divya , Bachani Sumitra , Sharma Anuradha 
Published: June 2023

AbstractObjectiveTo determine the predicted probability percentage of complications in women with pre‐eclampsia using the Pre‐eclampsia Integrated Estimate of Risk (fullPIERS) model within the first 24 h after admission and assess the model's predictive value for complications of pre‐eclampsia.MethodsThis was a prospective cohort study in which the fullPIERS model was applied to 256 pregnant women with pre‐eclampsia within the first 24 h after admission. These women were then followed for 48 h to 7 days for maternal and fetal complications. Reciever operating characteristics (ROC) curves were generated to assess the performance of the fullPIERS model for adverse outcomes of pre‐eclampsia.ResultsOf the 256 women enrolled in the study, 101 women (39.5%) developed maternal complications, 120 women (46.9%) developed fetal complications, and 159 women (62.1%) developed both. With an area under the ROC curve of 0.843 (95% confidence interval 0.789–0.897), the fullPIERS model had good discriminating ability to predict complications at any time point between 48 h and 7 days after admission. The sensitivity and specificity of the model at a ≥5.9% cut‐off value for predicting adverse maternal outcomes were 60% and 97%, respectively; they were 44% and 96%, respectively, for predicting combined fetomaternal complications with a cut‐off value of 4.9%.ConclusionsThe fullPIERS model performs reasonably well in predicting adverse maternal and fetal outcomes in women with pre‐eclampsia.
Ionic liquid engineering enabled in‐plane orientated 1D perovskite nanorods for efficient mixed‐dimensional perovskite photovoltaics
Authors: Wang Fei , Duan Dawei , Zhou Kang , Xue Y. Z. B. , Liang Xiao , Zhou Xianfang , Ge Chuangye , Zhou Chao , Xiang Jin , Zhu Jiajie , Zhu Quanyao , Lin Haoran , Shi Yumeng , Chen Yonghua , Li Gang , Hu Hanlin 
Published: June 2023

AbstractMixed‐dimensional engineering of perovskite material has been demonstrated as a facile and promising strategy to improve both photovoltaic performance and long‐term stability of perovskite solar cells (PSCs). In this study, we report an in‐plane preferred orientation of 1D perovskite induced by an ionic liquid (IL) of 1‐(3‐cyanopropyl)‐3‐methylimidazolium chloride (CPMIMCl) for the first time via sequential deposition approach, leading to a mixed dimensional perovskite thin films. The generated one‐dimensional (1D) CPMIMPbI3 with in‐plane orientation resides at the grain boundaries of three‐dimensional (3D) perovskite can be appreciably observed from the morphology level, leading to creation of high‐quality films with large grain size with more efficient defect passivation. Moreover, the dispersion of IL in the bulk phase of perovskite material allows for the formation of 1D perovskite for multiple level passivation to inhibit non‐radiative recombination and optimize carrier transport. This IL engineering strategy not only yields a mixed‐dimensional perovskite heterostructure with in‐plane orientation 1D perovskite nano‐rods but also significantly improves the opto‐electronic property with suppressed trap states. As a result, the CPMIMCl‐treated PSCs show an enhanced photovoltaic performance with a champion power conversion efficiency (PCE) up to 24.13%. More importantly, benefiting from the hydrophobicity of formed 1D perovskite and defects suppression, the corresponding PSC demonstrates an excellent long‐term stability and maintain 97.1% of its pristine PCE at 25°C under 50% RH condition over 1000 h. This research provides an innovative perspective for employing the low dimensional engineering to optimize the performance and stability of photovoltaic devices.image
Brazilian soybean expansion, US–China trade war, and US soybean exports
Authors: Dhoubhadel Sunil P. , Ridley William , Devadoss Stephen 
Published: June 2023

AbstractThis paper estimates the impact of Brazilian soybean area expansion on US and Brazilian soybean exports to China by projecting these countries’ exports for various Brazilian soybean area growth scenarios. The results indicate that the Brazilian area expansion does not significantly affect US soybean exports to China but positively impacts Brazil's soybean exports to China. Ex‐post analysis of the impacts of Chinese tariff during the US–China trade war indicates that China significantly diverted its imports from the United States to Brazil. We conclude that the US soybean trade policy should focus on mitigating the adverse effects of import demand changes.
Reduced GS Domain Serine/Threonine Requirements of Fibrodysplasia Ossificans Progressiva Mutant Type I BMP Receptor ACVR1 in the Zebrafish
Authors: Allen Robyn S. , Jones William D. , Hale Maya , Warder Bailey N. , Shore Eileen M. , Mullins Mary C. 
Published: June 2023

ABSTRACTFibrodysplasia ossificans progressiva (FOP) is a rare human genetic condition characterized by altered skeletal development and extraskeletal bone formation. All cases of FOP are caused by mutations in the type I bone morphogenetic protein (BMP) receptor gene ACVR1 that result in overactivation of the BMP signaling pathway. Activation of the wild‐type ACVR1 kinase requires assembly of a tetrameric type I and II BMP receptor complex followed by phosphorylation of the ACVR1 GS domain by type II BMP receptors. Previous studies showed that the FOP‐mutant ACVR1‐R206H required type II BMP receptors and presumptive glycine/serine‐rich (GS) domain phosphorylation for overactive signaling. Structural modeling of the ACVR1‐R206H mutant kinase domain supports the idea that FOP mutations alter the conformation of the GS domain, but it is unclear how this leads to overactive signaling. Here we show, using a developing zebrafish embryo BMP signaling assay, that the FOP‐mutant receptors ACVR1‐R206H and ‐G328R have reduced requirements for GS domain phosphorylatable sites to signal compared to wild‐type ACVR1. Further, ligand‐independent and ligand‐dependent signaling through the FOP‐mutant ACVR1 receptors have distinct GS domain phosphorylatable site requirements. ACVR1‐G328R showed increased GS domain serine/threonine requirements for ligand‐independent signaling compared to ACVR1‐R206H, whereas it exhibited reduced serine/threonine requirements for ligand‐dependent signaling. Remarkably, while ACVR1‐R206H does not require the type I BMP receptor partner, Bmpr1, to signal, a ligand‐dependent GS domain mutant of ACVR1‐R206H could signal independently of Bmpr1 only when Bmp7 ligand was overexpressed. Of note, unlike human ACVR1‐R206H, the zebrafish paralog Acvr1l‐R203H does not show increased signaling activity. However, in domain‐swapping studies, the human kinase domain, but not the human GS domain, was sufficient to confer overactive signaling to the Acvr1l‐R203H receptor. Together these results reflect the importance of GS domain activation and kinase domain functions in regulating ACVR1 signaling and identify mechanisms of reduced regulatory constraints conferred by FOP mutations. © 2023 American Society for Bone and Mineral Research (ASBMR).
Sleep disturbance and suicidality in psychiatrically hospitalized adolescents: The role of specific emotion regulation domains
Authors: Buitron Victor , Maron Micaela , Kudinova Anastacia , Thompson Elizabeth , Barker David H. , Wolff Jennifer C. 
Published: June 2023

AbstractBackgroundSleep disturbance is associated with broadband measurements of emotion regulation (ER). The linkage between ER, a multidimensional process, and suicidal ideation and suicide attempt is also documented in theoretical and empirical work. Recent research indicates that distinct profiles of ER are associated with psychiatric outcomes, including adolescent suicidal ideation and attempt. The present study examined whether specific domains of ER would explain the association between sleep disturbance, and ideation and attempt among psychiatrically hospitalized adolescents.MethodThe sample included 284 adolescents who completed self‐report measures on sleep disturbance, ER, suicidal ideation, suicide attempt, and psychiatric symptoms upon inpatient hospitalization.ResultsFindings indicated that sleep disturbance was associated with suicidal ideation. Further, a single ER domain (perceived limited access to ER strategies) fully accounted for the significant association between sleep disturbance and suicidal ideation. A reported suicide attempt in the past week was correlated with the nonacceptance of emotional responses, perceived limited access to ER strategies, and emotional clarity, but was not associated with sleep disturbance.DiscussionThe current findings highlight the importance of examining narrowband ER and indicate the presence of differential associations between sleep disturbance, ER, and suicide‐related outcomes. Findings further elucidate the possible role of impaired cognitive responses to emotional experiences in the co‐occurrence of sleep disturbance and youth psychiatric outcomes.
Disseminating online parenting resources through community‐academic partnerships
Authors: Schickler Ross , Park Alayna , Benfica Daniellee , Rodriguez Abigail , Eaton Emma , Bunge Eduardo 
Published: June 2023

AbstractThis community‐engaged study aimed to understand effective strategies for disseminating online parenting resources (OPRs) in schools. OPRs were disseminated through seven E‐Parenting tips and eight Facebook posts. Facebook posts were viewed a total of 12,404 times, and each post reached an average of 505 people each month. Average engagement rate was 2.41% per post. E‐Parenting tips yielded 1514 total clicks, and the average clicks per message was 216.29. E‐Parenting tips related to internalizing problems (e.g., anxiety, depression) had a higher click rate than E‐Parenting tips related to externalizing problems (e.g., oppositional behavior). OPRs disseminated through Facebook posts, and E‐Parenting tips resulted in wide reach and engagement. Different media channels should be utilized to disseminate different OPRs to as many parents as possible.
Chaperonin CCT controls extracellular vesicle production and cell metabolism through kinesin dynamics
Authors: Rojas‐Gómez Amelia , Dosil Sara G. , Chichón Francisco J. , Fernández‐Gallego Nieves , Ferrarini Alessia , Calvo Enrique , Calzada‐Fraile Diego , Requena Silvia , Otón Joaquin , Serrano Alvaro , Tarifa Rocio , Arroyo Montserrat , Sorrentino Andrea , Pereiro Eva , Vázquez Jesus , Valpuesta José M. , Sánchez‐Madrid Francisco , Martín‐Cófreces Noa B. 
Published: June 2023

SUMMARYCCT is required to regulate interorganelle contact sites through kinesin‐1 dynamics, modulating peroxisome and mitochondria activity, and ultimately controlling lipid cell content and metabolism.
Effect of laparoscopic liver resection on postoperative delirium in elderly patients with hepatocellular carcinoma
Authors: Nomi Takeo , Kaibori Masaki , Hirokawa Fumitoshi , Ueno Masaki , Hokuto Daisuke , Noda Takehiro , Nakai Takuya , Ikoma Hisashi , Iida Hiroya , Kubo Shoji 
Published: June 2023

AbstractBackgroundDelirium is a multifactorial and heterogeneous syndrome that is defined as acutely altered consciousness. This retrospective multicenter study evaluated the impact of postoperative delirium after liver resection for hepatocellular carcinoma (HCC) in elderly patients.MethodsPatients aged ≥75 years, who underwent curative liver resection for HCC at nine university hospitals from April 2010 to December 2017, were evaluated to compare short‐ and long‐term outcomes between patients with and without delirium. Risk factors for delirium were determined using multivariate regression analysis.ResultsThe rate of postoperative delirium was 14.2% (n = 80) in the study cohort of 562 patients. Multivariate analysis revealed smoking history, hypertension, sleeping pill consumption, and open liver resection as risk factors for postoperative delirium. The rate of other causes of death was significantly higher in the delirium group than in the no‐delirium group although the rate of death at 1 year due to HCC or liver failure was similar between the two groups (p = .015). The 1‐year mortality rates due to vascular diseases were 71.4% and 15.4% in the delirium and no‐delirium groups, respectively (p = .022). The 1‐, 3‐, and 5‐year survival rates after liver resection were 86.6%, 64.1%, and 36.5% in the delirium group and 91.3%, 71.2%, and 56.9% in the no‐delirium group, respectively (p = .046).ConclusionThe multivariate analysis revealed the possible benefits of laparoscopic liver resection in reducing the rate of postoperative delirium after liver resection for HCC in elderly patients.
Feasibility and criterion validity of the GLIM criteria in the critically ill: A prospective cohort study
Authors: Milanez Danielle Silla Jobim , Razzera Elisa Loch , Lima Júlia , Silva Flávia Moraes 
Published: June 2023

AbstractBackgroundThis study aimed to evaluate the feasibility and validity of the Global Leadership Initiative on Malnutrition (GLIM) criteria in the intensive care unit (ICU).MethodsThis was a cohort study involving critically ill patients. Diagnoses of malnutrition by the Subjective Global Assessment (SGA) and GLIM criteria within 24 h after ICU admission were prospectively performed. Patients were followed up until hospital discharge to assess the hospital/ICU length of stay (LOS), mechanical ventilation duration, ICU readmission, and hospital/ICU mortality. Three months after discharge, the patients were contacted to record outcomes (readmission and death). Agreement and accuracy tests and regression analyses were performed.ResultsGLIM criteria could be applied to 377 (83.7%) of 450 patients (64 [54–71] years old, 52.2% men). Malnutrition prevalence was 47.8% (n = 180) by SGA and 65.5% (n = 247) by GLIM criteria, presenting an area under the curve equal to 0.835 (95% confidence interval [CI], 0.790–0.880), sensitivity of 96.6%, and specificity of 70.3%. Malnutrition by GLIM criteria increased the odds of prolonged ICU LOS by 1.75 times (95% CI, 1.08–2.82) and ICU readmission by 2.66 times (95% CI, 1.15–6.14). Malnutrition by SGA also increased the odds of ICU readmission and the risk of ICU and hospital death more than twice.ConclusionThe GLIM criteria were highly feasible and presented high sensitivity, moderate specificity, and substantial agreement with the SGA in critically ill patients. It was an independent predictor of prolonged ICU LOS and ICU readmission, but it was not associated with death such as malnutrition diagnosed by SGA.
Optimization of chromatographic buffer conditions for the simultaneous analysis of phosphatidylinositol and phosphatidylinositol phosphate species in canola
Authors: Gertner David S , Bishop David P , Padula Matthew P 
Published: June 2023

The phosphatidylinositols and phosphatidylinositol phosphates are a set of closely related lipids known to influence various cellular functions. Irregular distributions of these molecules have been correlated with the development and progression of multiple diseases, including Alzheimer's, bipolar disorder, and various cancers. As a result, there is continued interest regarding the speciation of these compounds, with specific consideration on how their distribution may differ between healthy and diseased tissue. The comprehensive analysis of these compounds is challenging due to their varied and unique chemical characteristics, and current generalized lipidomics methods have proven unsuitable for phosphatidylinositol analysis and remain incapable of phosphatidylinositol phosphate analysis. Here we improved upon current methods by enabling the sensitive and simultaneous analysis of phosphatidylinositol and phosphatidylinositol phosphate species, whilst enhancing their characterization through chromatographic resolution between isomeric species. A 1 mM ammonium bicarbonate and ammonia buffer was determined optimal for this goal, enabling the identification of 148 phosphatidylinositide species, including 23 lyso‐phosphatidylinositols, 51 phosphatidylinositols, 59 oxidized‐phosphatidylinositols, and 15 phosphatidylinositol phosphates. As a result of this analysis, four distinct canola cultivars were differentiated based exclusively on their unique phosphatidylinositide‐lipidome, indicating analyses of this type may be of use when considering the development and progression of the disease through lipidomic profiles.
Spatial correlation and impact mechanism analysis of cultivated land fragmentation and quality in the Central Plain of Liaoning Province, Northeast China
Authors: Pang Ranran , Xu Huan , Zhang Meiyu , Qian Fengkui 
Published: June 2023

AbstractFurther exploration of the spatial correlation and mechanism of action between cultivated land fragmentation (CLF) and quality, which have guiding roles in improving cultivated land quality, is needed. However, the mechanism that determines how CLF affects quality has not yet been thoroughly investigated. The Central Plain of Liaoning Province was utilized as the research's study area, and the spatial autocorrelation analysis method was used to investigate the correlations between CLF and quality. The precise effects of different CLF indices on cultivated land quality have been specifically examined using the spatial error model (SEM). According to the findings, there is a “low in the west and high in the east” distribution tendency for CLF in the Central Plain area, and “high in the middle and low on both sides” for cultivated land quality. Furthermore, CLF and quality have a significant negative spatial link, with a correlation coefficient of −0.186. A rise in some CLF indices may enhance the difficulty of improving land quality. The quality of cultivated land declines by 0.275, 1.306, and 1.085 units for each unit rise in the number of patches (NP), edge density (ED), and aggregation index (AI) values, respectively. Therefore, it is possible to improve the degree of fragmentation of cultivated land according to local conditions, thereby improving the quality of cultivated land. The research results can provide a reference for achieving the trinity protection of cultivated land, in order to better improve the sustainability of cultivated land.
Fabrication of Highly Thermally Resistant and Self‐Healing Polysiloxane Elastomers by Constructing Covalent and Reversible Networks
Authors: Cai Yuanbo , Wang Yuan , Long Lu , Zhou Shengtai , Yan Liwei , Zhang Junhua , Zou Huawei 
Published: June 2023

AbstractThe fabrication of self‐healing elastomers with high thermal stability for use in extreme thermal conditions such as aerospace remains a major challenge. A strategy for preparing self‐healing elastomers with stable covalent bonds and dynamic metal–ligand coordination interactions as crosslinking sites in polydimethylsiloxane (PDMS) is proposed. The added Fe (III) not only serves as the dynamic crosslinking point at room temperature which is crucial for self‐healing performance, but also plays a role as free radical scavenging agent at high temperatures. The results show that the PDMS elastomers possessed an initial thermal degradation temperature over 380 °C and a room temperature self‐healing efficiency as high as 65.7%. Moreover, the char residue at 800 °C of PDMS elastomer reaches 7.19% in nitrogen atmosphere, and up to 14.02% in air atmosphere by doping a small amount (i.e., 0.3 wt%) of Fe (III), which is remarkable for the self‐healing elastomers that contain weak and dynamic bonds with relatively poor thermal stability. This study provides an insight into designing self‐healing PDMS‐based materials that can be targeted for use as high‐temperature thermal protection coatings.