bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the relationship between post‐disaster operating status of establishments and urban reconstruction projects and regulations in tsunami‐affected urban areas: Analysis of establishments affected by tsunami due to the Great East Japan Earthquake by individual panel data from Economic Census
Authors: Masumura Akinobu , Kubota Aya 
Published: September 2023

AbstractWhile urban reconstruction projects and land use regulations were implemented in each area affected by the tsunami following the Great East Japan Earthquake, concerns were raised regarding the impact of these projects and regulations on the industry sector. This study aimed to investigate the relationship between business recovery and post‐disaster urban planning, such as urban reconstruction projects and disaster risk area designations. We developed chronological panel data of establishment units before and after the disaster using individual data from Economic Census, inundation range data, urban reconstruction project zone data, and disaster risk area data. Cross‐tabulation tables and independence tests were conducted using the panel data. The results indicate that for establishments inundated to a depth of at least 1 m located outside the disaster risk area, the survival rate was significantly lower for those inside the urban reconstruction project area. For establishments outside the urban reconstruction project area, the survival rate was significantly lower for those inside the disaster risk area, for both nonflooded and flooded depths of at least 1 m. The results revealed that besides inundation damage, industry sectors, and numbers of employees, urban reconstruction project implementation and disaster risk area designation were some factors impeding survival.
Spatiotemporalized Hydrogel Microspheres Promote Vascularized Osteogenesis via Ultrasound Oxygen Delivery
Authors: Chen Shuyu , Han Xiaoyu , Cao Yang , Yi Weiwei , Zhu Ying , Ding Xiaoqian , Li Kai , Shen Jieliang , Cui Wenguo , Bai Dingqun 
Published: September 2023

AbstractDisturbance of spatiotemporal oxygen balance is the main cause of delayed healing or nonhealing of large bone defects. The accurate administration of oxygen to regulate disruptions in the spatiotemporal oxygen equilibrium during 9 h of hypoxia is imperative for bone tissue regeneration. Herein, oxygen‐loaded nanobubbles prepared by double emulsification are successfully embedded in GelMA/HepMA microsphere macromolecular meshwork by microfluidic techniques, and a spatiotemporalized hydrogel microsphere is constructed by noncovalently binding bone morphogenetic protein 2 (BMP‐2). The spatiotemporalized hydrogel microspheres precisely “remote control” oxygen release by ultrasound in vitro 9 h after bone injury to regulate spatiotemporal oxygen homeostasis disorder, maintain a high level of vascular endothelial growth factor (VEGF) expression, and accelerate bone repair. The spatiotemporalized hydrogel microspheres possess good oxygen‐carrying capacity and ultrasonic responsiveness, and the oxygen concentration increases to 1.63, 1.95, 2.11, and 2.29 times under the ultrasound action at different intensities of 1, 2, 3, and 4 W, respectively, providing the conditions for the precise regulation of spatiotemporal oxygen balance disorder by ultrasound. In the in vitro hypoxia model and in vivo rat femoral defect model, the spatiotemporal hydrogel microspheres show good vascularization and osteogenesis capabilities, which provide a new strategy for the clinical treatment of large bone defects.
Self‐Assembled Amphiphilic Camptothecin Nanoparticles with Glutathione‐Responsive and Tumor‐Targeting Ability for Enhanced Colorectal Cancer Therapy
Authors: Song XiaoJie , Lan Kang‐Li , Xue Yi‐Fei , Liu Hong‐Min , Lv Qi‐Yan , Zhao Zhen , Cui Hui‐Fang 
Published: September 2023

AbstractCamptothecin (CPT) is impeded by low solubility, non‐tumor‐targeting ability, and fast blood clearance. Self‐assembly of hydrophobic drugs into nanostructures, especially nanoparticles (NPs), can improve their anti‐cancer effects. In this study, arginine‐glycine‐aspartic acid (RGD), a hydrophilic and tumor‐targeting peptide, is conjugated with CPT through a glutathione‐cleavable disulfide bond. The synthesized amphiphilic molecule CPT‐ss‐RGD self‐assembled into stable NPs in an aqueous solution with diameters of ≈86nm. They exhibited low critical aggregation concentrations, good stability, and glutathione responsiveness. They can be specifically taken up by CRC cells through RGD integrin‐mediated uptake, and exhibit high toxicity to CRC cells and multicellular tumor spheroids. As expected, CPT‐ss‐RGD NPs prolonged the blood circulation time and enhanced the tumor accumulation of CPT, exhibiting excellent anti‐tumor growth ability and few side effects. Thus, CPT‐ss‐RGD NPs have great clinical translational potential for CRC therapy. The successful self‐assembly of the CPT‐ss‐RGD NPs provides a new method for the self‐delivery of hydrophobic therapeutics in vivo.
Scalable Generation of Pre‐Vascularized and Functional Human Beige Adipose Organoids
Authors: Escudero Mélanie , Vaysse Laurence , Eke Gozde , Peyrou Marion , Villarroya Francesc , Bonnel Sophie , Jeanson Yannick , Boyer Louisa , Vieu Christophe , Chaput Benoit , Yao Xi , Deschaseaux Frédéric , Parny Mélissa , Raymond‐Letron Isabelle , Dani Christian , Carrière Audrey , Malaquin Laurent , Casteilla Louis 
Published: September 2023

AbstractObesity and type 2 diabetes are becoming a global sociobiomedical burden. Beige adipocytes are emerging as key inducible actors and putative relevant therapeutic targets for improving metabolic health. However, in vitro models of human beige adipose tissue are currently lacking and hinder research into this cell type and biotherapy development. Unlike traditional bottom‐up engineering approaches that aim to generate building blocks, here a scalable system is proposed to generate pre‐vascularized and functional human beige adipose tissue organoids using the human stromal vascular fraction of white adipose tissue as a source of adipose and endothelial progenitors. This engineered method uses a defined biomechanical and chemical environment using tumor growth factor β (TGFβ) pathway inhibition and specific gelatin methacryloyl (GelMA) embedding parameters to promote the self‐organization of spheroids in GelMA hydrogel, facilitating beige adipogenesis and vascularization. The resulting vascularized organoids display key features of native beige adipose tissue including inducible Uncoupling Protein‐1 (UCP1) expression, increased uncoupled mitochondrial respiration, and batokines secretion. The controlled assembly of spheroids allows to translate organoid morphogenesis to a macroscopic scale, generating vascularized centimeter‐scale beige adipose micro‐tissues. This approach represents a significant advancement in developing in vitro human beige adipose tissue models and facilitates broad applications ranging from basic research to biotherapies.
Artificial Neurons Using Ag−In−Zn−S/Sericin Peptide‐Based Threshold Switching Memristors for Spiking Neural Networks
Authors: He Nan , Yan Jie , Zhang Zhining , Qin Haiming , Hu Ertao , Wang Xinpeng , Zhang Hao , Chen Pu , Xu Feng , Sheng Yang , Zhang Lei , Tong Yi 
Published: September 2023

AbstractMemristive devices with threshold switching characteristics can be effectively utilized to mimic biological neurons acting as one of the key building blocks for constructing advanced hardware neural networks. In this work, the emulation of leaky integrate‐and‐fire memristive neuron is realized in one single cell with Ag/Ag−In−Zn−S/silk sericin/W architecture without the need for additional auxiliary circuits. The studied devices demonstrate excellent electrical properties, such as stably repeatable threshold switching, concentratedly low threshold voltage (≈0.4 V), and relatively small device‐to‐device variation. In addition, multiple neural features, such as leaky integrate‐and‐fire neuron functionality and strength‐modulated spike frequency characteristic, have been successfully emulated owing to the forming‐free volatile threshold switching effect. The stable volatile threshold switching behaviors and regular firing event may be attributed to the controllable metallic Ag filamentary mechanism. Furthermore, a solid accuracy of 91.44% of the pattern recognition of Modified National Institute of Standards and Technology (MNIST) data is obtained via a trained spiking neural network (SNN) based on the leaky integrate‐and‐fire behavior of sericin‐based device. These achievements shed light on the fact that employing sericin biomaterials has great application potential in advanced neuromorphic computation.
Solution‐processed D‐A‐π‐A‐D radicals for highly efficient photothermal conversion
Authors: Huang Jiaxing , Wang Zejun , Zhu Weiya , Li Yuan 
Published: September 2023

AbstractOrganic donor‐acceptor semiconductors exhibit great potential in photothermal conversion. However, it is still challenging to achieve pure organic materials with broad absorption comparable with inorganic materials such as graphene. Herein, two D‐A‐D type DPA‐BT‐O4 and NDI‐TPA‐O4 and three D‐A‐π‐A‐D type Th‐O4, Th2‐O4, and IDT‐O4 were readily prepared via two high‐yield steps and simple air oxidization. The stability can be attributed to their multiple resonance structures based on the aromatic nitric acid radical mechanism. Compared with the D‐A‐D radicals, the conjugation extension of the D‐A‐π‐A‐D radicals endows them with a narrowed band gap and broad absorption in powder. Interestingly, the IDT‐O4 powder with aggregation‐induced radical effect exhibits broad absorption between 300 and 2500 nm, which is comparable with graphene and other inorganic materials. Under irradiation of 0.9 W/cm2 (808 nm), the temperature of IDT‐O4 powder rises to 250°C within 60 s. The water evaporation conversion efficiency of 94.38 % and an evaporation rate of 1.365 kg/m2 h−1 under one sun illumination were achieved. IDT‐O4 stands as one of the most efficient photothermal conversion materials among pure organic materials via a rational design strategy.
Analyzing the occurrence of foaming in batch fermentation processes using multiway partial least square approaches
Authors: Nguyen Xuan Dung James , Sharma Niket , Liu Y. A. , Lee Youngju , McDowell Christopher C. 
Published: September 2023

AbstractThis article presents an application of multiway partial least squares (MPLS) methods to develop interpretative correlation models to monitor the foaming occurrence and improve batch fermentation. We choose the exhaust differential pressure as a quality variable to quantify the foaming occurrence and consider three‐dimensional datasets of different batches, process variables, and measurements. We integrate batch‐wise unfolding (BWU) and observation‐wise unfolding (OWU) of plant datasets with standard, dynamic, and kernel PLS methods. We find that dynamic PLS (DPLS) with OWU and time‐lagged quality variables to be the most efficient, accurate, and easy to implement. The BWU approach is useful for analyzing the differences between batches and identifying abnormalities and outliers, while the OWU quantifies the variation within a given batch. With OWU, the DPLS method with one unit of time lag in the quality variable is the most effective, accurate, and easy to implement. With both BWU and OWU, we identify the quantitative effects of process variables on the quality variable and providence guidance to improve fermentation performance.
Higher Procedural Volumes Are Associated with Faster Treatment Times, Better Functional Outcomes, and Lower Mortality in Patients Undergoing Endovascular Treatment for Acute Ischemic Stroke
Authors: Nogueira Raul G. , Haussen Diogo C. , Smith Eric E. , Sun Jie‐Lena , Xian Ying , Alhanti Brooke , Blanco Rosalia , Mac Grory Brian , Doheim Mohamed F. , Bhatt Deepak L. , Fonarow Gregg C. , Hassan Ameer E. , Joundi Raed A. , Mocco J , Frankel Michael R. , Schwamm Lee H. 
Published: September 2023

ObjectiveWe aimed to characterize the association of hospital procedural volumes with outcomes among acute ischemic stroke (AIS) patients undergoing endovascular therapy (EVT).MethodsThis was a retrospective, observational cohort study using data prospectively collected from January 1, 2016 to December 31, 2019 in the Get with the Guidelines–Stroke registry. Participants were derived from a cohort of 60,727 AIS patients treated with EVT within 24 hours at 626 hospitals. The primary cohort excluded patients with pretreatment National Institutes of Health Stroke Scale (NIHSS) < 6, onset‐to‐treatment time > 6 hours, and interhospital transfers. There were 2 secondary cohorts: (1) the EVT metrics cohort excluded patients with missing data on time from door to arterial puncture and (2) the intravenous thrombolysis (IVT) metrics cohort only included patients receiving IVT ≤4.5 hours after onset.ResultsThe primary cohort (mean ± standard deviation age = 70.7 ± 14.8 years; 51.2% female; median [interquartile range] baseline NIHSS = 18.0 [13–22]; IVT use, 70.2%) comprised 21,209 patients across 595 hospitals. The EVT metrics cohort and IVT metrics cohort comprised 47,262 and 16,889 patients across 408 and 601 hospitals, respectively. Higher procedural volumes were significantly associated with higher odds (expressed as adjusted odds ratio [95% confidence interval] for every 10‐case increase in volume) of discharge to home (1.03 [1.02–1.04]), functional independence at discharge (1.02 [1.01–1.04]), and lower rates of in‐hospital mortality (0.96 [0.95–0.98]). All secondary measures were also associated with procedural volumes.InterpretationAmong AIS patients primarily presenting to EVT‐capable hospitals (excluding those transferred from one facility to another and those suffering in‐hospital strokes), EVT at hospitals with higher procedural volumes was associated with faster treatment times, better discharge outcomes, and lower rates of in‐hospital mortality. ANN NEUROL 2024;95:146–155
The reliability of parametric methods in the case of rating scales: A simulation study
Authors: Kindermann Harald 
Published: September 2023

AbstractA recurring question is whether rating scales should be considered metrically scaled or merely ordinally scaled. This has direct implications for the permissible statistical procedures for significance testing. Based on the results of a simulation study, it is shown that the use of parametric procedures for rating scales has distinct advantages over the nonparametric alternatives. It is also shown that the parametric procedures are robust to violations of the assumption of normality, which only result in a modest loss of power compared with continuous variables. This loss should be taken into account when calculating the optimal sample size. The results suggest that sample sizes about 25% larger should be chosen for discrete rating scales than for continuous variables.
Photo‐Induced Carbonylation of Aryl Bromides for the Synthesis of Aryl Esters and Amides Under Transition Metal‐Free Conditions
Authors: Zheng Yan , Teng Bing‐Hong , Zhang Youcan , Wu Xiao‐Feng 
Published: September 2023

AbstractIn this work, we developed a photo‐induced carbonylation of aryl bromides under transition metal‐free conditions. The reaction shows good activity with alcohol and amine nucleophiles. Various esters and amides were formed from aryl halides and alcohols and amines under mild conditions in moderate to good yields.
Randomized controlled trial on the effect of 1‐hour infusion of vincristine versus push injection on neuropathy in children with cancer (final analysis)
Authors: Uittenboogaard Aniek , van den Berg Marleen H. , Abbink Floor C. H. , Twisk Jos W. R. , van der Sluis Inge M. , van den Bos Cor , van den Heuvel‐Eibrink Marry M. , Segers Heidi , Chantrain Christophe , van der Werff ten Bosch Jutte , Willems Leen , Kaspers Gertjan J. L. , van de Velde Mirjam Esther 
Published: September 2023

AbstractIntroductionVincristine is an integral component of treatment for children with cancer. Its main dose‐limiting side effect is vincristine‐induced peripheral neuropathy (VIPN). The VINCA trial was a randomized controlled trial that explored the effect of 1‐hour infusion compared with push injection of vincristine on the development of VIPN in children with cancer. The short‐term outcomes (median follow‐up 9 months) showed that there was no difference in VIPN between the randomization groups. However, 1‐hour infusion was less toxic in children who also received azoles. We now report the results of the final analyses (median follow‐up 20 months), which includes treatment outcome as a secondary objective (follow‐up 3 years).MethodsVIPN was measured 1–7 times per participant using the Common Terminology Criteria for Adverse Events (CTCAE) and the pediatric‐modified total neuropathy score. Poisson mixed model and logistic generalized estimating equation analysis for repeated measures were performed.ResultsForty‐five participants per randomization group were included. There was no significant effect of 1‐hour infusion compared with push injection on VIPN. In participants receiving concurrent azoles, the total CTCAE score was significantly lower in the one‐hour group (rate ratio 0.52, 95% confidence interval 0.33–0.80, p = 0.003). Four patients in the one‐hour group and one patient in the push group relapsed. Two patients in the one‐hour group died.Conclusion1‐hour infusion of vincristine is not protective against VIPN. However, in patients receiving concurrent azoles, 1‐hour infusion may be less toxic. The difference in treatment outcome is most likely the result of differences in risk profile.
Perspectives for immunotherapy ofEBV‐associatedGLELC: A relatively “hot” tumor microenvironment
Authors: Lei Yanna , Cao Peng , Zheng Xiufeng , Wei Jing , Cheng Mo , Liu Ming 
Published: September 2023

AbstractBackgroundEpstein–Barr virus (EBV)‐associated gastric lymphoepithelioma‐like carcinoma (EBVaGLELC) represents a small number of gastric cancer (GC), and research on tumor microenvironment (TME) and treatment strategy are still lacking.AimsHere, we aim to elucidate the immune features of this rare disease and further help to develop more effective treatment options.Materials & MethodsA retrospective analysis was conducted between 2019 to 2022 in West China Hospital to reveal the immunological characteristics of EBV‐positive GLELC. The difference of immune cell subset and tumor vascular structure between gastric denocarcinoma (GAC) and EBVaGLELC will be pointed out.Discussion13 patients with GELEC and 8 patients with GAC were retrospectively studied. The heterogeneity of the immune cell profile was then confirmed through multiplexed immunofluorescence staining (mIF), which revealed a higher proportion of CD3+T cells, CD8+T cells, and Treg cells in the EBV‐associated GLELC group. Such a distinct TME may provide therapeutic advantages, and patients with this rare subtype of GC could be good candidates for immune checkpoint inhibitors (ICIs). Angiogenesis in EBV‐positive GLELC may be less intense than that in gastric adenocarcinoma (GAC), a feature that might decrease their susceptibility to antiangiogenic therapy. Furthermore, we reported a 52‐year‐old male with advanced EBV‐positive GLELC who showed a favorable response to the combined therapy with . A repeat evaluation showed sustained partial response (PR), and the progression‐free survival (PFS) was more than 34 months until now.ConclusionCompared with GAC, EBVaGLELC revealed higher T cell infiltration and less intense of angiogenesis. It displays relatively “hot” TME that may provide the rationality to treat with immunotherapy in EBV‐related GLELC.
How should extra‐large Lugol‐unstained lesions of the esophagus be treated? Results from a population‐based cohort study
Authors: Liu Mengfei , Qi Zifan , Zhou Ren , Guo Chuanhai , Liu Anxiang , Yang Haijun , Li Fenglei , Duan Liping , Shen Lin , Wu Qi , Liu Zhen , Pan Yaqi , Liu Fangfang , Liu Ying , Cai Hong , He Zhonghu , Ke Yang 
Published: September 2023

AbstractBackgroundCurrent guidelines recommend only severe dysplasia and above (SDA) lesions of the esophageal squamous epithelium for clinical intervention. However, the histopathologic diagnosis derived from tissue biopsies may be subject to underestimation of severity.Methods1073 participants from whom biopsies were taken at baseline chromoendoscopic examination in a population‐based screening trial were enrolled in this study. The size of the Lugol‐unstained lesions (LULs) was mainly analyzed. The outcome was defined as SDA lesions either identified at baseline screening, or during follow‐up, collectively referred to as the cumulative risk of SDA. Multivariable logistic regression models were used to evaluate the cumulative risk of SDA.ResultsOne hundred and forty‐six SDA cases were identified in the study period. Participants with large LULs had a high cumulative incidence of SDA (cumulative incidence16–20mm: 55.88%; cumulative incidence>20mm: 76.92%) in the median of 7‐year duration. LULs of large size were significantly associated with a higher cumulative risk of SDA, regardless of the pathologic diagnosis (adjusted OR16–20mmvs.≤5mm = 21.02, 95% CI: 7.56–58.47; adjusted OR>20mmvs.≤5mm = 33.62, 95% CI: 11.79–95.87).ConclusionsResults from this study suggest physician–patient shared decision‐making regarding clinical treatment or intensive surveillance should be carried out for LULs >20 mm in the esophagus, regardless of the histologic diagnosis. For those with LULs of 16–20 mm, intensive surveillance would also best be considered.
Isocyanide‐Based One‐Pot Cascade Synthesis of 3‐Acyl Isoindolinones†
Authors: Liu Jia , Zhu Yi‐Ming , Xu Xiao‐Ping , Ji Shun‐Jun 
Published: September 2023

Comprehensive SummaryA series of 3‐acyl‐substituted isoindolinone derivatives were synthesized in a one‐pot manner via the reaction of o‐bromobenzaldehydes, isocyanides, and carboxylic acids in the presence of palladium catalyst and base. The reaction employing easily available starting materials features simple operation and high efficiency. The mechanistic study showed that the reaction might undergo 1) Pd‐catalyzed [3+2] cyclization of o‐bromobenzaldehyde with isocyanide and the re‐insertion of another molecule of isocyanide, 2) addition of carboxylic acid to in situ formed ketenimine followed by a rearrangement relay to give 3,3‐diacyl‐substituted isoindolinone derivative. Further transformations of the obtained products through decarbonylation could also be realized.