bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient hybrid enhanced genetic algorithm and ant colony system model for rerouting multimedia message in multiple node–link failures within wireless network
Authors: Owoade Ayoade A. , Ogundile Olayinka O. , Babalola Oluwaseyi P. , Balyan Vipin 
Published: April 2023

SummaryFailure‐resilient wireless networks have attracted the interest of the research community and have been an open area of concern in the studies of wireless network in recent years. Accordingly, different research on restoration techniques have been carried out to proffer solution to the network component failures. In the same vein, this article proposes a hybridized enhanced genetic algorithm and ant colony system (EGAACS) survivability model, which can instantly resolve node–link failure problems, thus improving the quality of service of the wireless network. The EGAACS is a hybrid model that combines the principles of the enhanced genetic algorithm (EGA) and ant colony system (ACS) models to form a capacity efficiency solution that outperforms the ACS and EGA models in terms of path cost and transmission delay. The resilience of this proposed EGAACS model is verified for different wireless network sizes (20, 30, 40, and 50 node networks). Simulation results show that the proposed EGAACS model generates the best close to optimal paths in terms of the path cost and transmission delay in comparison to the EGA and ACS models. In fact, the performance of the proposed EGAACS model is more conspicuous as the size of the network increases. More importantly, the proposed EGAACS model is suitable for real‐time wireless network as it exhibits moderate computational time complexity.
Maternal hair cortisol predicts periodic and aperiodic infant frontal EEG activity longitudinally across infancy
Authors: Brandes‐Aitken Annie , Pini Nicolò , Weatherhead Matthew , Brito Natalie H. 
Published: April 2023

AbstractMaternal stress is known to be an important factor in shaping child development, yet the complex pattern of associations between stress and infant brain development remains understudied. To better understand the nuanced relations between maternal stress and infant neurodevelopment, research investigating longitudinal relations between maternal chronic physiological stress and infant brain function is warranted. In this study, we leveraged longitudinal data to disentangle between‐ from within‐person associations of maternal hair cortisol and frontal electroencephalography (EEG) power at three time points across infancy at 3, 9, and 15 months. We analyzed both aperiodic power spectral density (PSD) slope and traditional periodic frequency band activity. On the within‐person level, maternal hair cortisol was associated with a flattening of frontal PSD slope and an increase in relative frontal beta. However, on the between‐person level, higher maternal hair cortisol was associated with steeper frontal PSD slope, increased relative frontal theta, and decreased relative frontal beta. The within‐person findings may reflect an adaptive neural response to relative shifts in maternal stress levels, while the between‐person results demonstrate the potentially detrimental effects of chronically elevated maternal stress. This analysis offers a novel, quantitative insight into the relations between maternal physiological stress and infant cortical function.
A healthy but depleted herd: Predators decrease prey disease and density
Authors: Lopez Laura K. , Cortez Michael H. , DeBlieux Turner S. , Menel Ilona A. , O'Brien Bruce , Cáceres Carla E. , Hall Spencer R. , Duffy Meghan A. 
Published: April 2023

AbstractThe healthy herds hypothesis proposes that predators can reduce parasite prevalence and thereby increase the density of their prey. However, evidence for such predator‐driven reductions in the prevalence of prey remains mixed. Furthermore, even less evidence supports increases in prey density during epidemics. Here, we used a planktonic predator–prey–parasite system to experimentally test the healthy herds hypothesis. We manipulated density of a predator (the phantom midge, Chaoborus punctipennis) and parasitism (the virulent fungus Metschnikowia bicuspidata) in experimental assemblages. Because we know natural populations of the prey (Daphnia dentifera) vary in susceptibility to both predator and parasite, we stocked experimental populations with nine genotypes spanning a broad range of susceptibility to both enemies. Predation significantly reduced infection prevalence, eliminating infection at the highest predation level. However, lower parasitism did not increase densities of prey; instead, prey density decreased substantially at the highest predation levels (a major density cost of healthy herds predation). This density result was predicted by a model parameterized for this system. The model specifies three conditions for predation to increase prey density during epidemics: (i) predators selectively feed on infected prey, (ii) consumed infected prey release fewer infectious propagules than unconsumed prey, and (iii) sufficiently low infection prevalence. While the system satisfied the first two conditions, prevalence remained too high to see an increase in prey density with predation. Low prey densities caused by high predation drove increases in algal resources of the prey, fueling greater reproduction, indicating that consumer–resource interactions can complicate predator–prey–parasite dynamics. Overall, in our experiment, predation reduced the prevalence of a virulent parasite but, at the highest levels, also reduced prey density. Hence, while healthy herds predation is possible under some conditions, our empirical results make it clear that the manipulation of predators to reduce parasite prevalence may harm prey density.
Circulating immune checkpoints predict heart failure outcomes
Authors: Screever Elles M. , Yousif Laura I.E. , Moslehi Javid J. , Salem Joe‐Elie , Voors Adriaan A. , Silljé Herman H.W. , de Boer Rudolf A. , Meijers Wouter C. 
Published: April 2023

AbstractAimsThere are limited data examining the role of immune checkpoint (IC) ligands in the pathophysiology of heart failure (HF). Therefore, we explore this in three HF animal models and in three different human cohorts (healthy, stable, and worsening HF).Methods and resultsTranscriptomic analyses of cardiac tissue of three different HF mouse models revealed differentially expressed IC receptors and their ligands compared with control mice. Based on this observation, serum levels of three well‐known IC ligands (i.e. sPD‐L1, sPD‐L2 and galectin‐9) were measured in stable HF patients from the Vitamin D Chronic Heart Failure (VitD‐CHF) study (n = 101), as well as healthy individuals from the Prevention of Renal and Vascular End‐stage Disease (PREVEND) study (n = 58). sPD‐L1, sPD‐L2, and galectin‐9 were all associated with New York Heart Association classification. In multivariate linear regression analyses, all three IC ligands were associated with galectin‐3 (β = 0.230, β = 0.283, and β = 0.304, respectively). sPD‐L1 and galectin‐9 were also associated with hs‐troponin‐T (β = 0.386 and β = 0.314). Regarding prognosis, higher serum levels of sPD‐L1 and galectin‐9 were significantly associated with increased risk for HF hospitalization and all‐cause mortality [hazard ratio 1.69 (1.09–2.59) and hazard ratio 1.50 (1.06–2.12)]. Furthermore, the importance of IC ligands was tested in another stage of HF, namely worsening HF patients. In the worsening HF cohort (The BIOlogy Study to Tailored Treatment in Chronic Heart Failure) (n = 2032), sPD‐L2 and galectin‐9 were associated with New York Heart Association classification and significantly predicted outcome with an increased relative risk of 15% and 20%, after multivariable adjustment, respectively.ConclusionsIC ligands are expressed in cardiac disease models, and serum levels of IC ligands are elevated in HF patients, are associated with disease severity, and significantly predict prognosis. These data indicate a potential role for IC ligands in HF pathogenesis.
Channel inception through bottom‐current erosion of pockmarks revealed by numerical simulation
Authors: Yu Kaiqi , Lefebvre Alice , Li Wei , Zhan Wenhuan , Miramontes Elda 
Published: April 2023

AbstractIn deep‐marine environments, the inception of channels can be induced by the interaction between bottom currents and rough topography. However, it is still unclear under which conditions such features can form and what happens in the earliest phase of channel development. In this study, based on the morphological, sedimentary and oceanographic settings of a pockmark field in the NW South China Sea, we reveal the process of channel inception through the erosion of pockmarks by bottom currents. Using numerical simulations, we show that an appropriate current velocity can induce the erosion of pockmark trains in cohesive sediments, leading to the coalescence of discrete pockmarks and the formation of a channel with a rough thalweg. The interaction of bottom currents with the pockmarks induces a significant erosion along the pockmarks axis. Bottom‐current erosion is strongest at the downstream edges of pockmarks, where the horizontal velocity reaches a maximum and an upwelling forms. Erosion increases as the distance between pockmarks reduces. In our simulation results, a channel is only formed by the coalescence of pockmarks if the distance between pockmarks is <6 times the diameter of the pockmark. This study provides evidence of the formation of channels by bottom currents, which helps reconstruct palaeoceanographic conditions based on sediment architecture. It also shows the complex hydrodynamics at these structures that strongly control sedimentary processes and may affect distribution of benthic ecosystems in marine environments.
Improvement of phytochemical and quality characteristics of Dracocephalum kotschyi by drying methods
Authors: Zamani Sahar , Bakhshi Davood , Sahraroo Amir , Ebadi Mohammad‐Taghi 
Published: April 2023

AbstractThis experiment was conducted to evaluate the effects of different drying methods on drying parameters and qualitative characteristics of Dracocephalum kotschyi in a completely randomized design with three replications. Treatments included shade drying as control, sun drying, cabinet drying (CD at 50 and 60°C), refractance window drying (RWD), infrared drying (IRD) at 200 and 300 W, and combination of RWD+ IRD at 200 and 300 W. According to the results, IRD, RWD, and RWD+ IRD effectively maintained valuable secondary metabolites compared to the conventional drying methods. The maximum total phenol content (2.7 and 2.66 mg GAE/g dry weight), total flavonoid content (2.26 and 2.33 mg QE/g dry weight), antioxidant activity (79% and 78.33%), and essential oil content (0.65% and 0.76%) were obtained from plants dried by RWD and IRD. Samples dried by RWD, IRD, and RWD+ IRD had high color quality, acceptable green color, and less browning. Also, RWD and IRD methods effectively reduced microbial contamination of dried plants compared to the control and other methods. The minimum aerobic mesophiles, mold, yeast, and coliforms were observed at 3.11, 0, and 1.47 log CFU/g in IRD 300 W and 3.17, 1, and 1.30 log CFU/g in RWD. D. kotschyi dried at CD 50°C had the maximum microbial contamination. Generally, according to the obtained results, RWD and IRD methods are suggested for drying of D. kotschyi and similar herbs due to shortening the drying time, preserving and improving the quality properties of dried plants.
Direct localization and delineation of human pedunculopontine nucleus based on a self‐supervised magnetic resonance image super‐resolution method
Authors: Li Jun , Guan Xiaojun , Wu Qing , He Chenyu , Zhang Weimin , Lin Xiyue , Liu Chunlei , Wei Hongjiang , Xu Xiaojun , Zhang Yuyao 
Published: April 2023

AbstractThe pedunculopontine nucleus (PPN) is a small brainstem structure and has attracted attention as a potentially effective deep brain stimulation (DBS) target for the treatment of Parkinson's disease (PD). However, the in vivo location of PPN remains poorly described and barely visible on conventional structural magnetic resonance (MR) images due to a lack of high spatial resolution and tissue contrast. This study aims to delineate the PPN on a high‐resolution (HR) atlas and investigate the visibility of the PPN in individual quantitative susceptibility mapping (QSM) images. We combine a recently constructed Montreal Neurological Institute (MNI) space unbiased QSM atlas (MuSus‐100), with an implicit representation‐based self‐supervised image super‐resolution (SR) technique to achieve an atlas with improved spatial resolution. Then guided by a myelin staining histology human brain atlas, we localize and delineate PPN on the atlas with improved resolution. Furthermore, we examine the feasibility of directly identifying the approximate PPN location on the 3.0‐T individual QSM MR images. The proposed SR network produces atlas images with four times the higher spatial resolution (from 1 to 0.25 mm isotropic) without a training dataset. The SR process also reduces artifacts and keeps superb image contrast for further delineating small deep brain nuclei, such as PPN. Using the myelin staining histological atlas as guidance, we first identify and annotate the location of PPN on the T1‐weighted (T1w)‐QSM hybrid MR atlas with improved resolution in the MNI space. Then, we relocate and validate that the optimal targeting site for PPN‐DBS is at the middle‐to‐caudal part of PPN on our atlas. Furthermore, we confirm that the PPN region can be identified in a set of individual QSM images of 10 patients with PD and 10 healthy young adults. The contrast ratios of the PPN to its adjacent structure, namely the medial lemniscus, on images of different modalities indicate that QSM substantially improves the visibility of the PPN both in the atlas and individual images. Our findings indicate that the proposed SR network is an efficient tool for small‐size brain nucleus identification. HR QSM is promising for improving the visibility of the PPN. The PPN can be directly identified on the individual QSM images acquired at the 3.0‐T MR scanners, facilitating a direct targeting of PPN for DBS surgery.
International publication trends in basic, applied, and conceptual behavior‐analytic journals
Authors: Curiel Hugo , Curiel Emily S. L. 
Published: April 2023

AbstractThe analysis of international and collaborative publication trends in prominent behavior‐analytic journals has been a topic of interest for behavioral researchers. This paper focuses on publication trends from 1997 through 2020 in three prominent journals: Journal of the Experimental Analysis of Behavior (JEAB), Journal of Applied Behavior Analysis (JABA), and Perspectives on Behavior Science (PBS). The variable of interest was the percentage of articles published per geographical category—Australasia/East Asia, Europe, Latin America, Middle East, North America, and Africa. The results showed that 79, 96, and 87% of the published articles in JEAB, JABA, and PBS, respectively, were conducted by researchers with a North American affiliation. Furthermore, 12, 4, and 4% of the articles in JEAB, JABA, and PBS, respectively, were coauthored by at least two researchers from different geographical categories.
Front Cover
Authors: He Bin , Zhang Yuxin , Meng Zhe , He Zhijun , Wang Chengming , Chen Zhenyu , Yin Zichen , Hu Zhangwei , Shi Yejiong , Zhang Ning , Zhang Wenxin , Wang Guihuai , Xue Ping 
Published: April 2023

OCTA can provide in‐vivo 3D microvasculature of bio‐tissue but faces challenges with motion sensitivity and time constraints. Our adaptive, efficient scanning protocol and motion compensation algorithms address these issues. Employing a high‐resolution spectral‐domain OCT system, our innovative OCTA method enhances vascular imaging performance and reconstructs human skin's relative blood speed imaging.Further details can be found in the article by Bin He, Yuxin Zhang, Zhe Meng, Zhijun He, Chengming Wang, Zhenyu Chen, Zichen Yin, Zhangwei Hu, Yejiong Shi, Ning Zhang, Wenxin Zhang, Guihuai Wang, and Ping Xue (e202200340)
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Policy effects of the expansion of telehealth under 1135 waivers on intentions to seek counseling services: Difference‐in‐difference (DiD) analysis
Authors: Zhai Yusen , Carney JoLynn V. , Hazler Richard J. 
Published: April 2023

AbstractPracticing counselors swiftly shifted to telehealth after insurance payers changed their policy to cover telehealth counseling under the expansion of telehealth with 1135 waivers, which has led to concerns over the policy effects on clients’ continuing counseling service‐seeking intentions. To determine if this shift to telehealth was associated with a change in clients’ counseling service‐seeking intentions while adjusting for unmeasured confounders and time trends, we performed a difference‐in‐difference analysis (a quasi‐experimental design) to compare changes between the client (treated) and non‐client (control) groups through a large national sample of emerging adults (N = 52,237). The study findings indicated that the shift to telehealth was not associated with a change in clients’ counseling service‐seeking intentions, providing support for the utility of telehealth counseling. Implications of these findings should be considered when assessing the merit of telehealth counseling to inform public policies and counseling practice in the post‐pandemic era.
The digital frontier as a liminal space
Authors: Belk Russell 
Published: April 2023

AbstractHadi et al. (Journal of Consumer Psychology, 34, 2023) have created a masterful and wide‐sweeping review of the consumer behavior literature on the Metaverse. They envision our encounter with the Metaverse as a consumer journey. In this commentary, I highlight some of their unique contributions and suggest additional insights that emerge when we view the digital frontier as a liminal place betwixt and between now and then, here and there, and reality and virtuality. The Metaverse is also a metaphor and I entertain three metaphoric interpretations. First, the Metaverse is an experience machine of the sort that Robert Nozick imagined in his thought experiment involving real and artificial pleasures. Alternatively, consumers themselves can be seen as desiring machines as Gilles Deleuze and Féliz Guattari characterized them, and the Metaverse can be seen as an instantiation of our collective desires. Or thirdly, the Metaverse can be regarded as a shared hallucination. As these diverse metaphors suggest, imagining the metaverse is a projective exercise. But the consequences may involve up to a trillion dollars in revenues, so I hope these provocations prove useful whether they are ultimately borne out or not.
Clinical presentation and management modalities of gallbladder cancer in Sudan: A single‐center study
Authors: Adam Khatab M. , Abdelrahim Elfatih Yousif , Doush Wael Mohialddin , Abdelaziz Muataz S. 
Published: April 2023

AbstractBackground and AimGallbladder cancer (GBC) is a rare and highly aggressive malignancy characterized by late presentation of nonspecific symptoms, poor curability, and high mortality. The gold standard for effective treatment depends on early detection and surgical excision. Hence, the aim of this study was to determine the patterns of clinical presentation and management modalities to reach excellent practice.MethodsA retrospective study was conducted during the period from May 2021 to April 2022 at Ibn Sina specialized hospital, Khartoum, Sudan, on 50 patients with GBC who underwent a preoperative clinical and radiological evaluation to enable the use of appropriate surgical and oncological approaches.ResultsGBC was more prevalent in females in this series where all had GBC (68%), in the ratio 2:1. Distribution of patients according to age ranged between 61 and 75 years, representing 44% of patients. Abdominal pain, nausea, and vomiting were present in 40% of patients. Fifty‐six percent of patients resided in urban areas. Transabdominal ultrasound (TUS) with CT scan diagnosed GBC in 54% of patients. GBC was metastatic (stage IV) in 52% of patients. Based on preoperative decision by a multidisciplinary team (MDT), 62% of patients had palliative nonsurgical oncological treatment. Histopathological analysis of the resected GBC showed adenocarcinoma in 74% of cases. The inoperable patients (42%) were treated palliativelly with endoscopic retrograde cholangiopancreatography/systemic chemotherapy. Finally, the overall mortality rate was 56%.ConclusionsAccurate early clinical diagnosis and advanced radiological modalities with curative surgical approaches including clear surgical resection margins and systemic oncological therapies will potentially help in improving GBC survival outcomes.
Impact of inflammatory cytokine and adipokine gene variations in the development of HIV‐associated lipodystrophy
Authors: Namdev Goldi , Choudhari Ranjana , Shyamveer  , Khan Abdul Arif , Ali Nemat , Rashid Summya , Singh Hari Om 
Published: April 2023

AbstractCytokines affect lipid and glucose metabolism and also alter the body's habitus. They play a role in the development of lipodystrophy syndrome. Adipocytes secrete the pro‐inflammatory cytokines IL‐1, TNF‐α and IL‐6. The plasma cytokine concentration is associated with the percentage and distribution of fat tissue in the body. The metabolic disturbances are strongly associated with increased levels of pro‐inflammatory cytokines (IL‐1, IL‐6 and TNF‐α). Plasma levels of cytokines such as TNF‐α, IL‐6 and leptin were found to be increased while plasma resistin levels were found to be variable in patients suffering from obesity and type II diabetes mellitus. Until now, limited information has been available on the polymorphism of cytokine and adipokine genes in patients of HIV‐associated lipodystrophy (HIVLD), which can contribute to individual variations in susceptibility to metabolic diseases, especially to HIVLD. Hence, we studied the association of cytokine and adipokine gene polymorphisms in various diseases and their impact on HIVLD. We carry out an extensive search using several databases, including PubMed, EMBASE and Google Scholar. The distribution of cytokine and adipokine gene polymorphisms and their expression levels varied among various populations. We examined the variants of cytokine and adipokine genes, which can contribute to individual variations in susceptibility to metabolic diseases, especially to HIVLD. In the current review, we present a brief account of the risk factors of HIVLD, the pathogenesis of HIVLD and the polymorphism of cytokine and adipokine genes in various diseases with special reference to their impact on HIVLD.
IGH::CD274 (PD‐L1) rearrangement in diffuse large B cell lymphoma and its therapeutic implication
Authors: Wu Xuemei , Chen Si , Chen Ping , Zhang Han , Zhang Liying , Wang Panjun , Li Bingzong , Rong Rong , Wang Yiting , Lang Xingping , Wang Kai , Zhang Xiaohui , Xiao Sheng 
Published: April 2023

AbstractDiffuse large B cell lymphoma (DLBCL) expresses abundant programmed death ligand 1 (PD‐L1), which shields tumor cells from immune attacks through the PD‐L1/PD‐1 signaling axis. The mechanism of PD‐L1 overexpression includes the deletion of the 3′end of PD‐L1, which increases its mRNA stability, and the gain or amplification of PD‐L1. Previous studies found two cases of DLBCL carrying an IGH::PD‐L1 by whole genome sequencing. We describe two more such cases by a targeted DNA next‐generation sequencing (NGS) capable of detecting IGH rearrangements, leading to PD‐L1 overexpression. DLBCL with PD‐L1 overexpression is often resistant to R‐CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisolone). Our patients responded to a combination of R‐CHOP and a PD‐1 inhibitor.