bluuebunny/crossref_metadata_2025_split huggingface dataset:
Icacinaceae Plant Family: A Recapitulation of the Ethnobotanical, Phytochemical,
Pharmacological, and Biotechnological Aspects
Authors: Hazarika Sangeeta , Borah Pobitra , Deb Pran Kishore , Venugopala Katharigatta N. , Hemalatha Siva 
Published: May 2023

Abstract:
Icacinaceae, an Angiospermic family comprising 35 genera and 212 accepted species, including
trees, shrubs, and lianas with pantropical distribution, is one of the most outshining yet least explored plant
families, which despite its vital role as a source of pharmaceuticals and nutraceuticals has received a meagre
amount of attraction from the scientific community. Interestingly, Icacinaceae is considered a potential alternative
resource for camptothecin and its derivatives, which are used in treating ovarian and metastatic colorectal
cancer. However, the concept of this family has been revised many times, but further recognition is still needed.
The prime objective of this review is to compile the available information on this family in order to popularize
it in the scientific community and the general population and promote extensive exploration of these taxa. The
phytochemical preparations or isolated compounds from the Icacinaceae family have been centrally amalgamated
to draw diverse future prospects from this inclusive plant species. The ethnopharmacological activities
and the associated endophytes and cell culture techniques are also depicted. Nevertheless, the methodical evaluation
of the Icacinaceae family is the only means to preserve and corroborate the folkloristic remedial effects
and provide scientific recognition of its potencies before they are lost under the blanket of modernization.
MDAlmc: A Novel Low-rank Matrix Completion Model for MiRNADisease
Association Prediction by Integrating Similarities among MiRNAs
and Diseases
Authors: Zeng Xueying , Yang Jialiang , Wang Kun , Xu Junlin , Tian Geng , Li Yang 
Published: May 2023

Introduction:
The importance of microRNAs (miRNAs) has been emphasized by an increasing
number of studies, and it is well-known that miRNA dysregulation is associated with a variety
of complex diseases. Revealing the associations between miRNAs and diseases are essential to disease
prevention, diagnosis, and treatment.

Methods:
However, traditional experimental methods in validating the roles of miRNAs in diseases
could be very expensive, labor-intensive and time-consuming. Thus, there is a growing interest in predicting
miRNA-disease associations by computational methods. Though many computational methods
are in this category, their prediction accuracy needs further improvement for downstream experimental
validation. In this study, we proposed a novel model to predict miRNA-disease associations by
low-rank matrix completion (MDAlmc) integrating miRNA functional similarity, disease semantic
similarity, and known miRNA-disease associations. In the 5-fold cross-validation, MDAlmc achieved
an average AUROC of 0.8709 and AUPRC of 0.4172, better than those of previous models.

Results:
Among the case studies of three important human diseases, the top 50 predicted miRNAs of
96% (breast tumors), 98% (lung tumors), and 90% (ovarian tumors) have been confirmed by previous
literatures. And the unconfirmed miRNAs were also validated to be potential disease-associated miRNAs.

Conclusion:
MDAlmc is a valuable computational resource for miRNA–disease association prediction.
Natural Flavonoids as Potential Therapeutics in the Management of
Diabetic Wound: A Review
Authors: Chanu Nongmaithem Randhoni , Gogoi Pal , Barbhuiya Pervej Alom , Dutta Partha Pratim , Pathak Manash Pratim , Sen Saikat 
Published: May 2023

Abstract:
Flavonoids are important bioactive phenolic compounds abundant in plants and exhibit different therapeutic potentials. A wound is a significant problem in diabetic individuals. A hyper-glycaemic environment alters the normal wound-healing process and increases the risk of microbial infection, leading to hospitalization, morbidity, and amputation. Flavonoids are an important class of phytochemicals with excellent antioxidant, anti-inflammatory, antimicrobial, antidiabetic, anti-tumor, and wound healing property. Quercetin, hesperidin, curcumin, kaempferol, apigenin, luteo-lin, morin, etc. have shown their wound healing potential. Flavonoids effectively exhibit antimicro-bial activity, scavenge reactive oxygen species, augment endogenous antioxidants, reduce the ex-pression and synthesis of inflammatory cytokines (i.e. IL-1β, IL-6, TNF-α, NF-κB), inhibit inflam-matory enzymes, enhance anti-inflammatory cytokine (IL-10), enhance insulin section, reduce insu-lin resistance, and control blood glucose level. Several flavonoids like hesperidin, curcumin, quer-cetin, rutin, naringin, and luteolin have shown their potential in managing diabetic wounds. Natural products that maintain glucose haemostatic, exert anti-inflammatory activity, suppress/inhibit mi-crobial growth, modulate cytokines, inhibit matrix metalloproteinase (MMP), stimulate angiogene-sis and extracellular matrix, and modulate growth factor can be considered as a potential therapeutic lead to treat diabetic wound. Flavonoids were found to play a positive role in management of dia-betic wounds by regulating MMP-2, MMP-8, MMP-9, MMP-13, Ras/Raf/ MEK/ERK, PI3K/Akt, and nitric oxide pathways. Therefore, it can be assumed that flavonoids could be potential therapeu-tics to prevent devastating effects of diabetic wounds. This paper focused on the potential role of flavonoids in managing diabetic wounds and discussed their possible mechanism of action.
Computational Insight into the Mechanism of Action of DNA Gyrase
Inhibitors; Revealing a New Mechanism
Authors: Muhammed Muhammed Tilahun , Aki-Yalcin Esin 
Published: May 2023

Background:
Discovery of novel antimicrobial agents is in need to deal with antibiotic resistance.
Elucidating the mechanism of action for established drugs contributes to this endeavor. DNA
gyrase is a therapeutic target used in the design and development of new antibacterial agents. Selective
antibacterial gyrase inhibitors are available; however, resistance development against them is a big challenge.
Hence, novel gyrase inhibitors with novel mechanisms are required.

Objective:
The aim of this study is to elucidate mode of action for existing DNA gyrase inhibitors and to
pave the way towards discovery of novel inhibitors.

Methods:
In this study, the mechanism of action for selected DNA gyrase inhibitors available was carried
out through molecular docking and molecular dynamics (MD) simulation. In addition, pharmacophore
analysis, density functional theory (DFT) calculations, and computational pharmacokinetics analysis of the
gyrase inhibitors were performed.

Results:
This study demonstrated that all the DNA gyrase inhibitors investigated, except compound 14, exhibit
their activity by inhibiting gyrase B at a binding pocket. The interaction of the inhibitors at Lys103 was
found to be essential for the binding. The molecular docking and MD simulation results revealed that compound
14 could act by inhibiting gyrase A. A pharmacophore model that consisted of the features that would
help the inhibition effect was generated. The DFT analysis demonstrated 14 had relatively high chemical
stability. Computational pharmacokinetics analysis revealed that most of the explored inhibitors were estimated
to have good drug-like properties. Furthermore, most of the inhibitors were found to be non-mutagenic.

Conclusion:
In this study, mode of action elucidation through molecular docking and MD simulation,
pharmacophore model generation, pharmacokinetic property prediction, and DFT study for selected DNA
gyrase inhibitors were carried out. The outcomes of this study are anticipated to contribute to the design of
novel gyrase inhibitors.
Screening and Identification of Key Genes for Cervical Cancer, Ovarian
Cancer and Endometrial Cancer by Combinational Bioinformatic Analysis
Authors: Pang Feng , Shi Dong , Yuan Lin 
Published: May 2023

Introduction:
Cervical cancer, ovarian cancer and endometrial cancer are the top three cancers
in women. With the rapid development of gene chip and high-throughput sequencing technology, it
has been widely used to study genomic functional omics data and identify markers for disease diagnosis
and treatment. At the same time, more and more public databases containing genetic data have appeared.
The result of the bioinformatic analysis can provide a diagnosis of new perspectives on cell
origin and differences.

Methods:
In this paper, three datasets about cervical cancer, ovarian cancer and endometrial cancer from
GEO were used to dig out common DEGs (differentially expressed genes) among cervical cancer/ovarian
cancer/endometrial cancer. DEGs contain 400 up-regulation genes and 157 down-regulation genes.

Results::
The results of GO (gene ontology) functional enrichment analysis show that the BP (biological
process) changes of DEGs are mainly in cell division, mitotic nuclear division, sister chromatid cohesion,
and DNA replication. The CC (cell component) function enrichments of DEGs were mainly in the
nucleoplasm, nucleus, condensed chromosome kinetochore, chromosome, centromeric region. The MF
(molecular function) function enrichments of DEGs were mainly in protein binding. The results of the
KEGG pathway analysis showed that the upregulation DEGs were mainly enriched in retinoblastoma
gene in the cell cycle, cellular senescence, oocyte meiosis, and pathways in cancer, while the downregulation
DEGs enriched in thiamine metabolism, protein processing in endoplasmic reticulum. Similarly,
the function of the most significant module was enriched in cell division, condensed chromosome kinetochore,
and microtubule motor activity.

Conclusion:
In the result, 4 of the top 10 hub genes (CCNA2, CCNB1, CDC6 and CDK1) will provide
help for future biomedical experimental research.
A Double-Emulsion Method for the Fabrication of PLA Single-Hole Hollow
Particles
Authors: Li Yanan , Zhang Liyun , Tian Rui , Pranantyo Dicky , Chen Linfeng , Xia Fan 
Published: May 2023

Background:
Polymeric hollow particles with a single-hole structure have attracted
broad interest due to their combined advantages of a hollow cavity and an opening hole in the
shell.

Aim:
In the past decades, much progress has been made in the fabrication of such particles with
various strategies. However, there is a lack of research on the easy fabrication of biodegradable
polylactide (PLA) single hole particles (PLA SHHPs).

Methods:
In this work, we reported a simple double emulsion method for the fabrication of PLA
SHHPs. The W/O/W double emulsion was formed by homogenizing PLA chloroform and brilliant
blue G (BBG) solution. Scanning electron microscopy and confocal laser scanning microscopy
were used for the characterization. It was found that the concentrations of PLA chloroform and
BBG solution both had a significant influence on the emulsion structure.

Result:
PLA SHHPs with a percentage >85% were obtained from the emulsion composed of
PLA chloroform (10.0 w%) and BBG solution (4 mM). The particle formation mechanism was
also proposed based on the result of the low interfacial tension between PLA chloroform/BBG
solution.

Conclusion:
The results may inspire new development of PLA particles with unique structures,
which are promising to be used in drug delivery, catalysis, microreaction and micromotors.
Determination Analysis of Leading Commodity in the Melonguane National Border Strategic Area (NBSA)
Authors: Hanim Wasifah , Prasca Hafni Adinda , Pertiwi Widhi Netraning , Yudawisastra Helin Garlinia , Sugiartiningsih Sugiartiningsih 
Published: April 2023

Border areas are the gateway for a country;generally, it is an underdeveloped area. This study aims to develop the economy based on only commodities in the National Strategic Activity Center (NSA) Melongguane, Kepulauan Talaud Regency, North Sulawesi Province. This study uses qualitative and quantitative approaches. The qualitative approach is based on the policy formulation of the North Sulawesi Provincial government and the Kepulauan Talaud Regency, namely the Regional Spatial Planning (RTRW) document. While the quantitative method with the Location Quotient (LQ) analysis. Based on the North Sulawesi Provincial Spatial Planning (RTRW) document shows that the leading commodities at the Melongguane National Strategic Activity Center (NSA) are Nutmeg, Coconut, Clove, and Tuna-Skipjack-cob. The Location Quotient (LQ) analysis shows that the sub-districts with potential nutmeg commodities are Kabaruan and Damau sub-districts. At the same time, the potential locations for developing Tuna-Skipjack-cob are Nanusa and Miangas Districts.
Serious Games Based on Cognitive Bias Modification and Learned Helplessness Paradigms for the Treatment of Depression: Design and Acceptability Study
Authors: Ghosh Arka , Agnihotri Jagriti , Bhalotia Sradha , Sati Bharat Kumar , Agarwal Latika , A Akash , Tandon Swastika , Meena Komal , Raj Shreyash , Azad Yatin , Gupta Silky , Gupta Nitin 
Published: May 2023

Background
Depression is a debilitating mental health disorder, with a large treatment gap. Recent years have seen a surge in digital interventions to bridge this treatment gap. Most of these interventions are based on computerized cognitive behavioral therapy. Despite the efficacy of computerized cognitive behavioral therapy–based interventions, their uptake is low and dropout rates are high. Cognitive bias modification (CBM) paradigms provide a complementary approach to digital interventions for depression. However, interventions based on CBM paradigms have been reported to be repetitive and boring.

Objective
In this paper, we described the conceptualization, design, and acceptability of serious games based on CBM paradigms and the learned helplessness paradigm.

Methods
We searched the literature for CBM paradigms that were shown to be effective in reducing depressive symptoms. For each of the CBM paradigms, we ideated how to create a game so that the gameplay was engaging while the active therapeutic component remained unchanged.

Results
We developed 5 serious games based on the CBM paradigms and the learned helplessness paradigm. The games include various core elements of gamification, such as goals, challenges, feedback, rewards, progress, and fun. Overall, the games received positive acceptability ratings from 15 users.

Conclusions
These games may help improve the effectiveness and engagement levels of computerized interventions for depression.
Data Quality Degradation on Prediction Models Generated From Continuous Activity and Heart Rate Monitoring: Exploratory Analysis Using Simulation
Authors: Hearn Jason , Van den Eynde Jef , Chinni Bhargava , Cedars Ari , Gottlieb Sen Danielle , Kutty Shelby , Manlhiot Cedric 
Published: May 2023

Background
Limited data accuracy is often cited as a reason for caution in the integration of physiological data obtained from consumer-oriented wearable devices in care management pathways. The effect of decreasing accuracy on predictive models generated from these data has not been previously investigated.

Objective
The aim of this study is to simulate the effect of data degradation on the reliability of prediction models generated from those data and thus determine the extent to which lower device accuracy might or might not limit their use in clinical settings.

Methods
Using the Multilevel Monitoring of Activity and Sleep in Healthy People data set, which includes continuous free-living step count and heart rate data from 21 healthy volunteers, we trained a random forest model to predict cardiac competence. Model performance in 75 perturbed data sets with increasing missingness, noisiness, bias, and a combination of all 3 perturbations was compared to model performance for the unperturbed data set.

Results
The unperturbed data set achieved a mean root mean square error (RMSE) of 0.079 (SD 0.001) in predicting cardiac competence index. For all types of perturbations, RMSE remained stable up to 20%-30% perturbation. Above this level, RMSE started increasing and reached the point at which the model was no longer predictive at 80% for noise, 50% for missingness, and 35% for the combination of all perturbations. Introducing systematic bias in the underlying data had no effect on RMSE.

Conclusions
In this proof-of-concept study, the performance of predictive models for cardiac competence generated from continuously acquired physiological data was relatively stable with declining quality of the source data. As such, lower accuracy of consumer-oriented wearable devices might not be an absolute contraindication for their use in clinical prediction models.
Investigating the Connections Between Delivery of Care, Reablement, Workload, and Organizational Factors in Home Care Services: Mixed Methods Study
Authors: Darwich Adam S , Boström Anne-Marie , Guidetti Susanne , Raghothama Jayanth , Meijer Sebastiaan 
Published: April 2023

Background
Home care is facing increasing demand due to an aging population. Several challenges have been identified in the provision of home care, such as the need for support and tailoring support to individual needs. Goal-oriented interventions, such as reablement, may provide a solution to some of these challenges. The reablement approach targets adaptation to disease and relearning of everyday life skills and has been found to improve health-related quality of life while reducing service use.

Objective
The objective of this study is to characterize home care system variables (elements) and their relationships (connections) relevant to home care staff workload, home care user needs and satisfaction, and the reablement approach. This is to examine the effects of improvement and interventions, such as the person-centered reablement approach, on the delivery of home care services, workload, work-related stress, home care user experience, and other organizational factors. The main focus was on Swedish home care and tax-funded universal welfare systems.

Methods
The study used a mixed methods approach where a causal loop diagram was developed grounded in participatory methods with academic health care science research experts in nursing, occupational therapy, aging, and the reablement approach. The approach was supplemented with theoretical models and the scientific literature. The developed model was verified by the same group of experts and empirical evidence. Finally, the model was analyzed qualitatively and through simulation methods.

Results
The final causal loop diagram included elements and connections across the categories: stress, home care staff, home care user, organization, social support network of the home care user, and societal level. The model was able to qualitatively describe observed intervention outcomes from the literature. The analysis suggested elements to target for improvement and the potential impact of relevant studied interventions. For example, the elements “workload” and “distress” were important determinants of home care staff health, provision, and quality of care.

Conclusions
The developed model may be of value for informing hypothesis formulation, study design, and discourse within the context of improvement in home care. Further work will include a broader group of stakeholders to reduce the risk of bias. Translation into a quantitative model will be explored.
Frecuencia de agudización en casos de retratamiento endodóntico con diferente longitud de obturación
Authors: Oropeza Ledezma Daniel , Luna Domínguez Jorge Humberto , Luna Lara Carlos Alberto , Oliver Parra Rogelio 
Published: May 2023

Introducción: la remoción completa de materiales de obturación y dentina contaminada del conducto radicular durante el retratamiento endodóntico puede influir en la aparición de agudización endodóntica. Objetivo: establecer la frecuencia de agudización endodóntica posterior al retratamiento endodóntico de dientes anterosuperiores con diferente longitud de obturación apical. Material y métodos: se eligieron 33 casos con fracaso endodóntico para este estudio. Según la longitud apical de la obturación inicial, los sujetos se dividieron en dos grupos: el grupo A (n = 23) fueron casos obturados entre 0.0 y 2.0 mm al ápice radiográfico (AR) y el grupo B (n = 10) casos obturados entre 2.1 y 6 mm cortos al AR. Las obturaciones con gutapercha se eliminaron con instrumentos ProTaper retreatment D1 a D3 (Dentsply-Sirona, Ballaigues, Switzerland) más cloroformo. Posteriormente los conductos radiculares se instrumentaron con limas K-flexofile. Los casos reinstrumentados fueron obturados con gutapercha (Higyenic, Coltene Whaledent) y Sealapex (Kerr Sybronendo, WA) durante la misma cita. Los pacientes tomaron 400 mg de ibuprofeno cada ocho horas durante 72 horas y registraron el dolor postoperatorio a las ocho, 24, 48 y 72 horas. Se definió como agudización la aparición de dolor severo y/o inflamación (dolor en escala Heft-Parker a partir de 114 mm). Se determinaron porcentajes de casos positivos a la palpación y percusión a las 72 horas en ambos grupos. Resultados: dos pacientes presentaron agudización (6%), ambos en el grupo A. El dolor postoperatorio fue de 21.2% en los pacientes del grupo A a las ocho horas y 9.1% a las 48 horas. No se encontraron diferencias estadísticamente significativas en la presencia de agudización entre grupos (p > 0.05). Conclusiones: la agudización de casos de retratamiento endodóntico es de 6%. La longitud de obturación de casos indicados para retratamiento endodóntico no influye en la frecuencia de agudización postoperatoria.
Colocación de implante en zona estética y regeneración de tejidos blandos utilizando técnica ''VISTA'
Authors: Ramírez Rodríguez Alejandro Darío , Gómez Chávez Jorge Armando , Rodríguez-Chávez Jacqueline Adelina , Magaña Curiel Karina , Curiel González Ricardo , Bayardo González Daniel Eduardo 
Published: May 2023

Introducción: los implantes dentales son un tratamiento alternativo para la fijación de prótesis en situaciones de edentulismo parcial o total. Los requisitos más importantes en la colocación de un implante dental son la cantidad, calidad de hueso y tejidos blandos en el sitio receptor. La técnica VISTA por sus siglas en inglés (vestibular incisión subperiosteal tunnel access) permite un aumento de volumen en sentido horizontal a partir de la regeneración de tejidos duros y blandos. Objetivo: presentar el tratamiento de una restauración implantosoportada en la región del diente 21, en la cual se realizaron injertos de tejido óseo y tejido conjuntivo para aumentar el volumen horizontal del reborde utilizando la técnica VISTA. Reporte de caso: paciente masculino de 42 años, motivo de consulta "he perdido un diente"; a la exploración intraoral se observó la ausencia del diente 21. Se le colocó un implante (Straumann, SLActive, ø 3.3, longitud 12mm) y se le realizó injerto óseo (xenoinjerto de origen bovino (NuOss) y conjuntivo (membrana de colágena reabsorbible (RCM6) en la región vestibular utilizando la técnica VISTA para incrementar el volumen horizontal del reborde residual. La corona se realizó mediante un pilar Variobase a base de zirconia con porcelana vestibular estratificada. Se consiguió un aumento de reborde en sentido horizontal (2 mm), una estabilidad de los tejidos de soporte duros y blandos alrededor del implante, logrando una restauración estética, biológica y funcionalmente adecuada. Conclusión: la técnica vista propone un enfoque prometedor para el tratamiento de sitios implantarios con tejidos duros y blandos insuficientes para la cobertura total de la superficie del implante.