bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-language activation of idiom meanings: Evidence from French– Vietnamese– and Indonesian–English bilinguals
Authors: Jared Debra , Nguyen Pearley , Grant-Pereira Alyssa , Rizkyana Qamara , Maziyah Mohamed Mirrah 
Published: July 2023

AbstractThe aim of the present study was to determine whether bilinguals activate the figurative meaning of an idiom that is specific to one language when they are exposed to its translation in their other language. We used a cross-modal priming task in which participants heard L2 English sentences that ended with an idiom translated from their L1. They then saw a visually presented stimulus that was either related to the meaning of the L1 idiom, a matched control word, or a nonword, and made a lexical decision. Three experiments were run, each with a different group of bilinguals (French–English, Vietnamese–English, and Indonesian–English), and each with a monolingual English control group. In all three studies, the effect of relatedness for bilinguals and monolinguals differed, demonstrating cross-language activation of idiom meanings. Evidence was obtained that suggested that culture-specific information in idioms influenced processing.
Continent‐Ocean Transition or Boundary? Crowd‐Sourced Seismic Interpretations of the East‐India Passive Margin
Authors: Bond Clare E. , Alcalde Juan , Butler Robert W. H. , McDermott Ken , Carbonell Ramon 
Published: July 2023

AbstractOn the edge of our continents, oceanic crust meets continental crust. At passive margins, those where there is no active tectonics, subduction or transform faulting, these crustal types are connected as sharp continent‐ocean boundaries (COB) or as diffuse continent‐ocean transition (COT) zones. Passive margins are hard to explore and consequently relatively little is known about their morphology or the geological processes of their formation. Here we elicit and analyze seismic image interpretations of the passive margin offshore East India conducted by 17 groups of geoscientists to better understand the differences, or lack therein, of COB or COT interpretations of the margin. The group interpretations provide a wide range of margin models, five of which are abrupt COB based and 11 which are diffuse COT based. However, interpretations within the COB set vary in the placement of the boundary line between continental and oceanic crust, the boundary placement lying within the range of interpreted COT zones, with the average COB location falling in the center of the interpreted COT zones. These crowd‐sourced results are then compared with 10 published interpretations across the margin, which show COB and COT zones falling in the same area. These findings raise questions as to the real differences in COB and COT models and the geological processes involved in their formation. Considering this, we discuss the implications for passive margin models and the use of Wisdom of Crowds‐type approaches in reflecting on both the range of interpretation‐based models and in the value of determining “average” model approaches.
The Impact of Human‐Induced Climate Change on Future Tornado Intensity as Revealed Through Multi‐Scale Modeling
Authors: Woods Matthew J. , Trapp Robert J. , Mallinson Holly M. 
Published: July 2023

AbstractA novel, multi‐scale climate modeling approach is used to show the potential for increases in future tornado intensity due to anthropogenic climate change. Historical warm‐ and cool‐season (WARM and COOL) tornado events are virtually placed in a globally warmed future via the “pseudo‐global warming” method. As hypothesized based on meteorological arguments, the tornadic‐storm and associated vortex of the COOL event experiences consistent and robust increases in intensity in an ensemble of imposed climate‐change experiments. The tornadic‐storm and associated vortex of the WARM event experiences increases in intensity in some of the experiments, but the response is neither consistent nor robust, and is overall weaker than in the COOL event. An examination of environmental parameters provides further support of the disproportionately stronger response in the cool‐season event. These results have implications on future tornadoes forming outside of climatologically favored seasons.
Influence of Lateral Plume Channel on the Evolution of Rift Arms of the Afar Triple Junction: Constraints From 3‐D Gravity Interpretation
Authors: Sreenidhi K. S. , Betts P. G. , Radhakrishna M. , Armit R. 
Published: July 2023

AbstractThe Afar region presents a unique example of a juvenile R‐R‐R triple junction with the arms evolved to various stages of maturity. The lithosphere in this area has been modified heterogeneously by the nearby Afar mantle plume. To gain a comprehensive and consistent understanding of the link between crustal geometry and geodynamics of the region and facilitate comparisons across different tectonic elements, we developed a high‐resolution crustal thickness map of the region that resolves major tectonic features. The calculation involved a well‐constrained 3‐D inversion of upper mantle‐corrected crustal Bouguer gravity anomalies computed with the help of tomography‐derived densities. Our results match earlier localized crustal thickness estimates, illustrating the method's efficacy. A thinner crust (∼20–26 km) is revealed in the Afar compared to adjacent continental regions. The Main Ethiopian Rift has the thickest crust in the central part of the rift (∼38–40 km) and thinner to the north (∼30 km) and south (∼35 km). The crustal thickness along the Gulf of Aden changes from east (∼5 km) to west (∼17 km) in the west, consistent with a westward transition from seafloor spreading to continental rifting. The southern Red Sea is characterized by asymmetric crustal thickness, with a thicker crust (∼17 km) on the eastern flank compared to the western flank (∼11 km), which we attribute to the influence of a sub‐lithospheric channel from the Afar mantle plume. We propose a model describing the channel leading to asymmetric features of the southern Red Sea, such as crustal accretion, marginal topography, and volcanism.
New Insights Into Scavenging Effect of Aerosol Species During Summer Rainfall Process in Beijing
Authors: Li Yan , Sun Jiaxing , Bi Yongheng , Wang Qingqing , Zhao Xiujuan , Lei Lu , Du Aodong , Li Zhijie , Wang Zifa , Pan Xiaole , Han Congzheng , Sun Yele 
Published: July 2023

AbstractPrecipitation is a critical factor in changing aerosol life cycle, yet its impact on aerosol species with different properties in megacities remains unclear. Here we characterized the changes of PM2.5 aerosol species during rainfall processes in five summers (2018–2022) in Beijing using highly time‐resolved measurements of aerosol chemical speciation monitor along with precipitation. Average pattern of 233 rainfall processes showed that over 30% decreases in aerosol species before rain start were due to the increased wind speed, and the subsequent decreases were caused by the combined effects of precipitation and winds with an average scavenging of 62%–100% in 1 hr. We also observed very different responses of aerosol species to precipitation depending on intensities, duration and formation mechanisms. During the rainfall processes, aerosol composition showed decreased contributions of organics and sulfate, particularly from late night to morning, while increased contributions of nitrate and chloride due to enhanced gas‐particle partitioning associated with the increase of relative humidity and the decrease of temperature. The scavenging rates of aerosol species significantly increased as the increase of rainfall intensity (>5 mm hr−1) and duration (>4 hr). However, the scavenging effect of light rainfall was negligible although the cumulative contribution was ∼50% due to high frequency, and even caused increases in nitrate and chloride. The case analysis of aerosol evolution during weak and heavy rainfall events further illustrated the dual impacts of precipitation on aerosol species through wet scavenging and secondary formation.
Alterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy
Authors: Gaynor Nicola , Blanco Alfonso , Madden Stephen F. , Moran Barry , Fletcher Jean M. , Kaukonen Damien , Ramírez Javier Sánchez , Eustace Alex J. , McDermott Martina S. J. , Canonici Alexandra , Toomey Sinead , Teiserskiene Ausra , Hennessy Bryan T. , O’Donovan Norma , Crown John , Collins Denis M. 
Published: July 2023

Abstract
Background
The phase II neo-adjuvant clinical trial ICORG10-05 (NCT01485926) compared chemotherapy in combination with trastuzumab, lapatinib or both in patients with HER2+ breast cancer. We studied circulating immune cells looking for alterations in phenotype, genotype and cytotoxic capacity (direct and antibody-dependent cell-mediated cytotoxicity (ADCC)) in the context of treatment response.

Methods
Peripheral blood mononuclear cells (PBMCs) were isolated from pre- (n = 41) and post- (n = 25) neo-adjuvant treatment blood samples. Direct/trastuzumab-ADCC cytotoxicity of patient-derived PBMCs against K562/SKBR3 cell lines was determined ex vivo. Pembrolizumab was interrogated in 21 pre-treatment PBMC ADCC assays. Thirty-nine pre-treatment and 21 post-treatment PBMC samples were immunophenotyped. Fc receptor genotype, tumour infiltrating lymphocyte (TIL) levels and oestrogen receptor (ER) status were quantified.

Results
Treatment attenuated the cytotoxicity/ADCC of PBMCs. CD3+/CD4+/CD8+ T cells increased following therapy, while CD56+ NK cells/CD14+ monocytes/CD19+ B cells decreased with significant post-treatment immune cell changes confined to patients with residual disease. Pembrolizumab-augmented ex vivo PBMC ADCC activity was associated with residual disease, but not pathological complete response. Pembrolizumab-responsive PBMCs were associated with lower baseline TIL levels and ER+ tumours.

Conclusions
PBMCs display altered phenotype and function following completion of neo-adjuvant treatment. Anti-PD-1-responsive PBMCs in ex vivo ADCC assays may be a biomarker of treatment response.
NRF2 transcriptionally regulates Caspase-11 expression to activate HMGB1 release by Autophagy-deficient hepatocytes
Authors: Khambu Bilon , Cai Genxiang , Liu Gang , Bailey Niani Tiaye , Mercer Arissa A. , Baral Kamal , Ma Michelle , Chen Xiaoyun , Li Yu , Yin Xiao-Ming 
Published: July 2023

AbstractInjury or stress can induce intracellular translocation and release of nuclear HMGB1, a DAMP molecule known to participate in inflammation and other pathological processes. Active release of HMGB1 from stimulated macrophages can be mediated by inflammasomes, which cleave Gasdermin D to form pores on cytoplasmic membranes. We previously had shown that active release of HMGB1 from autophagy deficient hepatocytes also depended on the inflammasome but how the inflammasome was activated was not known. Here we report that persistent activation of transcription factor NRF2 under the autophagy deficient condition led to transcriptional upregulation of Caspase-11 expression, which could then activate the CASPASE-1inflammasome. Using chromatin immunoprecipitation (CHIP) and luciferase-based reporter assays, we show that NRF2 directly binds to the Caspase-11 promoter and transcriptionally increase the expression of Caspase-11. Genetic deletion of Caspase-11 in autophagy-deficient livers represses the release of HMGB1 and its pathological consequence, ductular cell proliferation. Consistently, deletion of NLRP3, which can activate CASPASE-1 mediated inflammasomes under other types of signals, did not prevent HMGB1 release and ductular cell proliferation in autophagy deficient livers. Surprisingly, while cleavage of GASDEMIN D occurred in autophagy-deficient livers its deletion did not prevent the HMGB1 release, suggesting that CASPASE-11-mediated inflammasome activation may also engage in a different mechanism for HMGB1 release by the autophagy deficient hepatocytes. Collectively, this work reveals the novel role of NRF2 in transcriptional upregulation of Caspase-11 and in inflammasome activation to promote active release of HMGB via a non-Gasdermin D mediated avenue.
Extracellular vesicles from neural progenitor cells promote functional recovery after stroke in mice with pharmacological inhibition of neurogenesis
Authors: Campero-Romero Aura N. , Real Fernando H. , Santana-Martínez Ricardo A. , Molina-Villa Tonatiuh , Aranda Cristina , Ríos-Castro Emmanuel , Tovar-y-Romo Luis B. 
Published: July 2023

AbstractNeural progenitor cells (NPCs) of the subventricular zone proliferate in response to ischemic stroke in the adult mouse brain. Newly generated cells have been considered to influence recovery following a stroke. However, the mechanism underlying such protection is a matter of active study since it has been thought that proliferating NPCs mediate their protective effects by secreting soluble factors that promote recovery rather than neuronal replacement in the ischemic penumbra. We tested the hypothesis that this mechanism is mediated by the secretion of multimolecular complexes in extracellular vesicles (EVs). We found that the molecular influence of oxygen and glucose-deprived (OGD) NPCs-derived EVs is very limited in improving overt neurological alterations caused by stroke compared to our recently reported astrocyte-derived EVs. However, when we inhibited the ischemia-triggered proliferation of NPCs with the chronic administration of the DNA synthesis inhibitor Ara-C, the effect of NPC-derived EVs became evident, suggesting that the endogenous protection exerted by the proliferation of NPC is mainly carried out through a mechanism that involves the intercellular communication mediated by EVs. We analyzed the proteomic content of NPC-derived EVs cargo with label-free relative abundance mass spectrometry and identified several molecular mediators of neuronal recovery within these vesicles. Our findings indicate that NPC-derived EVs are protective against the ischemic cascade activated by stroke and, thus, hold significant therapeutic potential.
Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis
Authors: Zhang Jianjian , Zhang Yao , Feng Dengyuan , Zhou Hai , Gui Zeping , Zheng Ming , Hang Zhou , Gu Min , Tan Ruoyun 
Published: July 2023

AbstractChronic allograft dysfunction (CAD) is a major factor that hinders kidney transplant survival in the long run. Epithelial–mesenchymal transition (EMT) has been confirmed to significantly contribute to interstitial fibrosis/tubular atrophy (IF/TA), which is the main histopathological feature of CAD. Aberrant expression of the regulator of calcineurin 1 (RCAN1), recognized as an endogenous inhibitor of the calcineurin phosphatase, has been shown to be extensively involved in various kidney diseases. However, it remains unclear how RCAN1.4 regulates IF/TA formation in CAD patients. Herein, an in vivo mouse renal transplantation model and an in vitro model of human renal tubular epithelial cells (HK-2) treated with tumor necrosis factor-α (TNF-α) were employed. Our results proved that RCAN1.4 expression was decreased in vivo and in vitro, in addition to the up-regulation of Yin Yang 1 (YY1), a transcription factor that has been reported to convey multiple functions in chronic kidney disease (CKD). Knocking in of RCAN1.4 efficiently attenuated chronic renal allograft interstitial fibrosis in vivo and inhibited TNF-α-induced EMT in vitro through regulating anti-oxidative stress and the calcineurin/nuclear factor of activated T cells cytoplasmic 1 (NFATc1) signaling pathway. In addition, suppression of YY1 mediated by shRNA or siRNA alleviated TNF-α-induced EMT through abolishing reactive species partly in an RCAN1.4-dependent manner. Notably, we confirmed that YY1 negatively regulated RCAN1.4 transcription by directly interacting with the RCAN1.4 promoter. In addition, histone deacetylase 2 (HDAC2) interacted with YY1 to form a multi-molecular complex, which was involved in TNF-α-induced RCAN1.4 transcriptional repression. Therefore, RCAN1.4 is suggested to be modulated by the YY1/HDAC2 transcription repressor complex in an epigenetic manner, which is a mediated nephroprotective effect partly through modulating O2⋅− generation and the calcineurin/NFATc1 signaling pathway. Thus, the YY1–RCAN1.4 axis constitutes an innovative target for IF/TA treatment in CAD patients.
Selective activation of STAT3 and STAT5 dictates the fate of myeloid progenitor cells
Authors: Zhang Meichao , Meng Yiling , Ying Yingxia , Zhou Pingting , Zhang Suning , Fang Yong , Yao Yuan , Li Dong 
Published: July 2023

AbstractThe molecular programs that govern the directed differentiation of myeloid progenitor cells are still poorly defined. Using a previously established immortalized, phenotypically normal myeloid progenitor cell model mEB8-ER, we unveil a new mechanism mediated by STAT5 and STAT3 at a bifurcation point of myeloid progenitor cell-fate specification. We find that myeloid progenitor cells can spontaneously differentiate into neutrophils with a basal level of STAT3 phosphorylation, which is enhanced by G-CSF treatment or STAT3 over-expression, leading to elevated neutrophil differentiation. Reduced STAT3 phosphorylation caused by GM-CSF treatment, STAT3 specific inhibitor, or STAT3 depletion leads to attenuated myeloid differentiation into neutrophils, while elevating differentiation into monocytes/macrophages. In contrast, STAT5 appears to have an antagonistic function to STAT3. When activated by GM-CSF, STAT5 promotes myeloid differentiation into monocytes/macrophages but inhibits neutrophil differentiation. At the mechanistic level, GM-CSF activates STAT5 to up-regulate SOCS3, which attenuates STAT3 phosphorylation and consequently neutrophil differentiation, while enhancing monocyte/macrophage differentiation. Furthermore, inhibition of STAT5 and STAT3 in primary myeloid progenitors recapitulates the results from the mEB8-ER model. Together, our findings provide new mechanistic insights into myeloid differentiation and may prove useful for the diagnosis and treatment of diseases related to abnormal myeloid differentiation.
Distinct types of multicellular aggregates in Pseudomonas aeruginosa liquid cultures
Authors: Melaugh Gavin , Martinez Vincent A. , Baker Perrin , Hill Preston J. , Howell P. Lynne , Wozniak Daniel J. , Allen Rosalind J. 
Published: July 2023

AbstractPseudomonas aeruginosaforms suspended multicellular aggregates when cultured in liquid media. These aggregates may be important in disease, and/or as a pathway to biofilm formation. The polysaccharide Psl and extracellular DNA (eDNA) have both been implicated in aggregation, but previous results depend strongly on the experimental conditions. Here we develop a quantitative microscopy-based method for assessing changes in the size distribution of suspended aggregates over time in growing cultures. For exponentially growing cultures ofP. aeruginosaPAO1, we find that aggregation is mediated by cell-associated Psl, rather than by either eDNA or secreted Psl. These aggregates arise de novo within the culture via a growth process that involves both collisions and clonal growth, and Psl non-producing cells do not aggregate with producers. In contrast, we find that stationary phase (overnight) cultures contain a different type of multicellular aggregate, in which both eDNA and Psl mediate cohesion. Our findings suggest that the physical and biological properties of multicellular aggregates may be very different in early-stage vs late-stage bacterial cultures.
Spectral kissing and its dynamical consequences in the squeeze-driven Kerr oscillator
Authors: Chávez-Carlos Jorge , Lezama Talía L. M. , Cortiñas Rodrigo G. , Venkatraman Jayameenakshi , Devoret Michel H. , Batista Victor S. , Pérez-Bernal Francisco , Santos Lea F. 
Published: July 2023

AbstractTransmon qubits are the predominant element in circuit-based quantum information processing, such as existing quantum computers, due to their controllability and ease of engineering implementation. But more than qubits, transmons are multilevel nonlinear oscillators that can be used to investigate fundamental physics questions. Here, they are explored as simulators of excited state quantum phase transitions (ESQPTs), which are generalizations of quantum phase transitions to excited states. We show that the spectral kissing (coalescence of pairs of energy levels) experimentally observed in the effective Hamiltonian of a driven SNAIL-transmon is an ESQPT precursor. We explore the dynamical consequences of the ESQPT, which include the exponential growth of out-of-time-ordered correlators, followed by periodic revivals, and the slow evolution of the survival probability due to localization. These signatures of ESQPT are within reach for current superconducting circuits platforms and are of interest to experiments with cold atoms and ion traps.
Emergent topological quantum orbits in the charge density wave phase of kagome metal CsV3Sb5
Authors: Tan Hengxin , Li Yongkang , Liu Yizhou , Kaplan Daniel , Wang Ziqiang , Yan Binghai 
Published: July 2023

AbstractThe recently discovered kagome materials AV3Sb5 (A = K, Rb, Cs) attract intense research interest in intertwined topology, superconductivity, and charge density waves (CDW). Although the in-plane 2 × 2 CDW is well studied, its out-of-plane structural correlation with the Fermi surface properties is less understood. In this work, we advance the theoretical description of quantum oscillations and investigate the Fermi surface properties in the three-dimensional CDW phase of CsV3Sb5. We derived Fermi-energy-resolved and layer-resolved quantum orbits that agree quantitatively with recent experiments in the fundamental frequency, cyclotron mass, and topology. We reveal a complex Dirac nodal network that would lead to a π Berry phase of a quantum orbit in the spinless case. However, the phase shift of topological quantum orbits is contributed by the orbital moment and Zeeman effect besides the Berry phase in the presence of spin-orbital coupling (SOC). Therefore, we can observe topological quantum orbits with a π phase shift in otherwise trivial orbits without SOC, contrary to common perception. Our work reveals the rich topological nature of kagome materials and paves a path to resolve different topological origins of quantum orbits.
LRRC10 regulates mammalian cardiomyocyte cell cycle during heart regeneration
Authors: Salamon Rebecca J. , McKeon Megan C. , Bae Jiyoung , Zhang Xiaoya , Paltzer Wyatt G. , Wanless Kayla N. , Schuett Alyssa R. , Nuttall Dakota J. , Nemr Stephen A. , Sridharan Rupa , Lee Youngsook , Kamp Timothy J. , Mahmoud Ahmed I. 
Published: July 2023

AbstractLeucine-rich repeat containing 10 (LRRC10) is a cardiomyocyte-specific protein, but its role in cardiac biology is little understood. Recently Lrrc10 was identified as required for endogenous cardiac regeneration in zebrafish; however, whether LRRC10 plays a role in mammalian heart regeneration remains unclear. In this study, we demonstrate that Lrrc10–/– knockout mice exhibit a loss of the neonatal mouse regenerative response, marked by reduced cardiomyocyte cytokinesis and increased cardiomyocyte binucleation. Interestingly, LRRC10 deletion disrupts the regenerative transcriptional landscape of the regenerating neonatal mouse heart. Remarkably, cardiac overexpression of LRRC10 restores cardiomyocyte cytokinesis, increases cardiomyocyte mononucleation, and the cardiac regenerative capacity of Lrrc10–/– mice. Our results are consistent with a model in which LRRC10 is required for cardiomyocyte cytokinesis as well as regulation of the transcriptional landscape during mammalian heart regeneration.