bluuebunny/crossref_metadata_2025_split huggingface dataset:
Förderung eines selbständigen Medikamentenmanagements
Authors: Schirmer Uwe Bernd 
Published: January 2023

Was ist zu diesem Thema bereits bekannt? Inzwischen werden Patient_innen im stationären und ambulanten Bereich zunehmend durch Pflegefachkräfte beim Medikamentenmanagement angeleitet. Zumeist bedeutet diese Anleitung ein gemeinsames Richten der Medikamente, manchmal kombiniert mit der Medikamenteneinnahme. Wie wird eine neue Perspektive eingebracht? Das nachfolgend beschriebene Medikamententrainingsprogramm (MTP) ist eine wirkungsvolle, evaluierte Intervention, die hilft, eine einheitliche Vorgehensweise aller Beteiligten zu sichern. Was sind die Auswirkungen für die Praxis? Das MTP nimmt die Bedenken und Sorgen der Patient_innen hinsichtlich der Medikation auf. Insbesondere die verlässliche Einnahme der Medikamente im häuslichen Kontext ist oft problematisch. Wir versuchen wegzukommen vom Ritual des Verteilens, das die Patient_innen passiv macht, hin zu einem gemeinsamen Handeln.
Neuroleptika absetzen und reduzieren
Authors: Zwicknagl Andrea , Burr Christian 
Published: January 2023

Was ist zu diesem Thema bereits bekannt? Neuroleptika gelten als Mittel der Wahl zur medikamentösen Behandlung von Menschen mit der Diagnose Schizophrenie. Nebenwirkungen sowie der Wunsch nach Reduzieren und Absetzen sind bei den Betroffenen häufig. In der Behandlung findet ein Austausch darüber oft nicht statt. Wie wird eine neue Perspektive eingebracht? Der Neuroleptika-Trialog bietet einen „sicheren“ Raum für diesen Austausch zwischen Betroffenen, Fachpersonen und Angehörigen, auch wenn die Beteiligung der Fachpersonen meist niedrig ist. Was sind die Auswirkungen für die Praxis? Es sollten in der Praxis Räume für einen solchen Austausch geschaffen werden. Fachpersonen können in Trialogen lernen, wie solche hilfreich gestaltet werden können.
Solar Cycle and Long‐Term Trends in the Observed Peak of the Meteor Altitude Distributions by Meteor Radars
Authors: Dawkins E. C. M. , Stober G. , Janches D. , Carrillo‐Sánchez J. D. , Lieberman R. S. , Jacobi C. , Moffat‐Griffin T. , Mitchell N. J. , Cobbett N. , Batista P. P. , Andrioli V. F. , Buriti R. A. , Murphy D. J. , Kero J. , Gulbrandsen N. , Tsutsumi M. , Kozlovsky A. , Kim J. H. , Lee C. , Lester M. 
Published: January 2023

AbstractThe mesosphere/lower thermosphere (MLT, 80–100 km) region is an important boundary between Earth's atmosphere below and space above and may act as a sensitive indicator for anthropogenic climate change. Existing observational and modeling studies have shown the middle atmosphere and the MLT is cooling and contracting because of increasing greenhouse gas emissions. However, trend analyses are highly sensitive to the time periods covered, their length, and the measurement type and methodology used. We present for the first time the linear and 11‐year solar cycle responses in the meteor ablation altitude distributions observed by 12 meteor radars at different locations. Decreasing altitudes were seen at all latitudes (linear trends varying from −10.97 to −817.95 m dec−1), and a positive correlation with solar activity was seen for most locations. The divergence of responses at high latitudes indicates an important and complex interplay between atmospheric changes and dynamics at varying time scales.
Microseismicity and lithosphere thickness at a nearly-amagmatic oceanic detachment fault system
Authors: Chen Jie , Crawford Wayne C. , Cannat Mathilde 
Published: January 2023

AbstractOceanic detachment faults play a central role in accommodating the plate divergence at slow-ultraslow spreading mid-ocean ridges. Successive flip-flop detachment faults in a nearly-amagmatic region of the ultraslow spreading Southwest Indian Ridge (SWIR) at 64°30’E accommodate ~100% of plate divergence, with mostly ultramafic smooth seafloor. Here we present microseismicity data, recorded by ocean bottom seismometers, showing that the axial brittle lithosphere is on the order of 15 km thick under the nearly-amagmatic smooth seafloor, which is no thicker than under nearby volcanic seafloor or at more magmatic SWIR detachment systems. Our data reveal that microearthquakes with normal focal mechanisms are colocated with seismically-imaged damage zones of the active detachment fault and of antithetic hanging-wall faults. The level of the hanging-wall seismicity is significantly higher than that documented at more magmatic detachments of slow-ultraslow ridges, which may be a unique feature of nearly-amagmatic flip-flop detachment systems.
DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation
Authors: Kwon Youngho , Rösner Heike , Zhao Weixing , Selemenakis Platon , He Zhuoling , Kawale Ajinkya S. , Katz Jeffrey N. , Rogers Cody M. , Neal Francisco E. , Badamchi Shabestari Aida , Petrosius Valdemaras , Singh Akhilesh K. , Joel Marina Z. , Lu Lucy , Holloway Stephen P. , Burma Sandeep , Mukherjee Bipasha , Hromas Robert , Mazin Alexander , Wiese Claudia , Sørensen Claus S. , Sung Patrick 
Published: January 2023

AbstractThe tumor suppressor BRCA2 participates in DNA double-strand break repair by RAD51-dependent homologous recombination and protects stressed DNA replication forks from nucleolytic attack. We demonstrate that the C-terminal Recombinase Binding (CTRB) region of BRCA2, encoded by gene exon 27, harbors a DNA binding activity. CTRB alone stimulates the DNA strand exchange activity of RAD51 and permits the utilization of RPA-coated ssDNA by RAD51 for strand exchange. Moreover, CTRB functionally synergizes with the Oligonucleotide Binding fold containing DNA binding domain and BRC4 repeat of BRCA2 in RPA-RAD51 exchange on ssDNA. Importantly, we show that the DNA binding and RAD51 interaction attributes of the CTRB are crucial for homologous recombination and protection of replication forks against MRE11-mediated attrition. Our findings shed light on the role of the CTRB region in genome repair, reveal remarkable functional plasticity of BRCA2, and help explain why deletion of Brca2 exon 27 impacts upon embryonic lethality.
A ferroptosis-related prognostic model with excellent clinical performance based on the exploration of the mechanism of oral squamous cell carcinoma progression
Authors: Fan Xin , Zhong Yun , Yuan Fang , Zhang Lingling , Cai Ying , Liao Lan 
Published: January 2023

AbstractAs a hot topic today, ferroptosis is closely involved in the progression and treatment of cancer. Accordingly, we built a prognostic model around ferroptosis to predict the overall survival of OSCC patients. We used up to 6 datasets from 3 different databases to ensure the credibility of the model. Then, through differentially expressed, Univariate Cox, and Lasso regression analyses, a model composed of nine prognostic-related differently expressed ferroptosis-related genes (CISD2, DDIT4, CA9, ALOX15, ATG5, BECN1, BNIP3, PRDX5 and MAP1LC3A) were constructed. Moreover, Kaplan–Meier curves, Receiver Operating Characteristic curves and principal component analysis used to verify the model's predictive ability showed the model's superiority. To deeply understand the mechanism of ferroptosis affecting the occurrence, development and prognosis of OSCC, we performed enrichment analysis in different risk groups identified by the model. The results showed that numerous TP53-related, immune-related and ferroptosis-related functions and pathways were enriched. Further immune microenvironment analysis and mutation analysis have once again revealed the correlation between risk score and immunity and TP53 mutation. Finally, the correlation between risk score and OSCC clinical treatment, as well as Nomogram show the brilliant clinical application prospects of the prognostic model.
The role of fear, closeness, and norms in shaping help towards war refugees
Authors: Kossowska Małgorzata , Szwed Paulina , Szumowska Ewa , Perek-Białas Jolanta , Czernatowicz-Kukuczka Aneta 
Published: January 2023

AbstractThe paper investigates the psychological factors associated with the unprecedented assistance that Poles have offered refugees from Ukraine since the outset of Russia’s invasion of Ukraine. Building on social identity theory, and examining the current social context in Poland, we focus on three social identity dimensions, i.e., a feeling of closeness towards refugees from Ukraine, anticipatory fears (of a Russian invasion), and a community norm of helping. These three dimensions predict collective helping resulting from a sense of a common fate and a feeling of togetherness with Ukrainians. We tested this hypothesis in a study (N = 1066) conducted between 11 and 17 March 2022. Participants were asked about their helping activities during the previous week; they also responded to questions on different measures of social identity processes. The results support our expectations, revealing that closeness, anticipatory fears, and social norms are associated with two forms of help: benevolent and activist. The results of the study contribute to the discussion on social identity processes underlying offers of help to people fleeing from war-zones. Thus, they enhance our understanding of the role of citizens in terms of their contribution to helping refugees, and can be used to improve responses to other humanitarian crises.
Synergy of ruthenium metallo-intercalator, [Ru(dppz)2(PIP)]2+, with PARP inhibitor Olaparib in non-small cell lung cancer cells
Authors: Yusoh Nur Aininie , Chia Suet Lin , Saad Norazalina , Ahmad Haslina , Gill Martin R. 
Published: January 2023

AbstractPoly(ADP-ribose) polymerase (PARP) are critical DNA repair enzymes that are activated as part of the DNA damage response (DDR). Although inhibitors of PARP (PARPi) have emerged as small molecule drugs and have shown promising therapeutic effects, PARPi used as single agents are clinically limited to patients with mutations in germline breast cancer susceptibility gene (BRCA). Thus, novel PARPi combination strategies may expand their usage and combat drug resistance. In recent years, ruthenium polypyridyl complexes (RPCs) have emerged as promising anti-cancer candidates due to their attractive DNA binding properties and distinct mechanisms of action. Previously, we reported the rational combination of the RPC DNA replication inhibitor [Ru(dppz)2(PIP)]2+ (dppz = dipyrido[3,2-a:2′,3′-c]phenazine, PIP = 2-(phenyl)-imidazo[4,5-f][1,10]phenanthroline), “Ru-PIP”, with the PARPi Olaparib in breast cancer cells. Here, we expand upon this work and examine the combination of Ru-PIP with Olaparib for synergy in lung cancer cells, including in 3D lung cancer spheroids, to further elucidate mechanisms of synergy and additionally assess toxicity in a zebrafish embryo model. Compared to single agents alone, Ru-PIP and Olaparib synergy was observed in both A549 and H1975 lung cancer cell lines with mild impact on normal lung fibroblast MRC5 cells. Employing the A549 cell line, synergy was confirmed by loss in clonogenic potential and reduced migration properties. Mechanistic studies indicated that synergy is accompanied by increased double-strand break (DSB) DNA damage and reactive oxygen species (ROS) levels which subsequently lead to cell death via apoptosis. Moreover, the identified combination was successfully able to inhibit the growth of A549 lung cancer spheroids and acute zebrafish embryos toxicity studies revealed that this combination showed reduced toxicity compared to single-agent Ru-PIP.
All oxide based flexible multi-folded invisible synapse as vision photo-receptor
Authors: Chen Ping-Xing , Panda Debashis , Tseng Tseung-Yuen 
Published: January 2023

AbstractAll oxide-based transparent flexible memristor is prioritized for the potential application in artificially simulated biological optoelectronic synaptic devices. SnOx memristor with HfOx layer is found to enable a significant effect on synaptic properties. The memristor exhibits good reliability with long retention, 104 s, and high endurance, 104 cycles. The optimized 6 nm thick HfOx layer in SnOx-based memristor possesses the excellent synaptic properties of stable 350 epochs training, multi-level conductance (MLC) behaviour, and the nonlinearity of 1.53 and 1.46 for long-term potentiation and depression, respectively, and faster image recognition accuracy of 100% after 23 iterations. The maximum weight changes of -73.12 and 79.91% for the potentiation and depression of the synaptic device, respectively, are observed from the spike-timing-dependent plasticity (STDP) characteristics making it suitable for biological applications. The flexibility of the device on the PEN substrate is confirmed by the acceptable change of nonlinearities up to 4 mm bending. Such a synaptic device is expected to be used as a vision photo-receptor.
Effect of pharmacogenetic variations on praziquantel plasma concentration and safety outcomes among school children in Rwanda
Authors: Barry Abbie , Kabatende Joseph , Telele Nigus Fikrie , Mnkugwe Rajabu Hussein , Mugisha Michael , Ntirenganya Lazare , Bienvenu Emile , Aklillu Eleni 
Published: January 2023

AbstractSchool-based mass drug administration (MDA) of Praziquantel (PZQ) is the global intervention strategy for elimination of schistosomiasis. Genetic variations in drug metabolizing enzymes and transporter proteins influences drug exposure and treatment outcomes, but data on PZQ pharmacokinetics and safety outcomes are scarce. We investigated the effect of pharmacogenetics variations on PZQ plasma concentrations and safety outcomes among 462 Rwandan schoolchildren who received single dose PZQ and albendazole in MDA. Genotyping for common functional variant alleles CYP3A4*1B, CYP3A5 (*3, *6, *7), CYP2C19 (*2, *3, *17), CYP2C9 (*2, *3) and CYP2J2*7 were done. Plasma concentration of PZQ, cis-4-OH-PZQ and trans-4-OH-PZQ were measured using LC/MS/MS. Active safety monitoring was done on days 1, 2, and 7 post-MDA. CYP2C9 and CYP2C19 genotypes were significantly associated with PZQ plasma concentrations and its cis- and trans-4-OH-PZQ/PZQ metabolic ratios (MR). CYP2C9*2 and CYP2C9*3 carriers had significantly higher PZQ concentration (p = 0.02), lower trans-4-OH-PZQ/PZQ (p < 0.001), and cis-4-OH-PZQ/PZQ (p = 0.02) MR. CYP2C19 (*2, *3) carriers had significantly higher plasma PZQ concentration than CYP2C19 *1/*1 and CYP2C19 *17 carriers (*1/*17 or *17/*17) (p < 0.001). CYP3A4 was significantly associated with cis-4-OH-PZQ MR (p = 0.04). Lower cis-4-OH-PZQ/PZQ MR (p < 0.0001) was a predictor of MDA-associated adverse events, but no significant association with genotypes were found. In conclusion, CYP2C9 and CYP2C19 genotypes significantly influence the plasma PZQ concentration and its MR. Lower cis-4-OH-PZQ/PZQ MR is significant predictor of adverse events following MDA.
Modification of sugarcane bagasse with iron(III) oxide-hydroxide to improve its adsorption property for removing lead(II) ions
Authors: Praipipat Pornsawai , Ngamsurach Pimploy , Sanghuayprai Amornrat 
Published: January 2023

AbstractLead contamination in wastewater results in toxicity of aquatic life and water quality, it is recommended to remove lead before discharging. Four sugarcane bagasse adsorbent materials of sugarcane bagasse powder (SB), sugarcane bagasse powder doped iron(III) oxide-hydroxide (SBF), sugarcane bagasse powder beads (SBB), and sugarcane bagasse powder doped iron(III) oxide-hydroxide beads (SBFB) were synthesized and characterized with various techniques. Their lead removal efficiencies were investigated by batch experiments on the effects of dose (0.1–0.6 g), contact time (1–6 h), pH (1, 3, 5, 7, 9, 11), and concentration (5–30 mg/L), adsorption isotherms, kinetics, and desorption experiments. All materials were amorphous phases presenting specific peaks of cellulose. SBB and SBFB detected sodium alginate peaks, and iron(III) oxide-hydroxide peaks were detected in SBF and SBFB. SB and SBF were scales or overlapping plate surfaces whereas SBB and SBFB had spherical shapes with coarse surfaces. The main functional groups of O–H, C=O, C–H, C–O, and C=C were observed in all materials, whereas Fe–O and –COOH were only found in materials with adding iron(III) oxide-hydroxide or bead material. The point of zero charges (pHpzc) of all materials was higher than 4. The optimum conditions of SB, SBF, SBB, and SBFB with the highest lead removal efficiency at a lead concentration of 10 mg/L and pH 5 were 0.6 g and 6 h (96.08%), 0.2 g and 3 h (100%), 0.2 g and 2 h (98.22%), and 0. 1 g and 2 h (100%), respectively. Since SBFB spent less adsorbent dose and contact time than other materials with a lead removal efficiency of 100%, it was a more potential adsorbent than other materials. Thus, adding iron(III) oxide-hydroxide and changing material form helped to improve material efficiencies for lead adsorption. The maximum adsorption capacities of SB, SBF, SBB, and SBFB were 6.161, 27.027, 23.697, and 57.471 mg/L, respectively by fitting the Langmuir model. Langmuir isotherm was best fitted for SB and SBB, whereas the Freundlich model was best fitted for SBF and SBFB. The pseudo-second-order kinetic model was best fitted for all materials. Moreover, all adsorbents could be reused for more than 5 cycles with the lead removal efficiency of more than 73%. Therefore, SBFB was potential material to further apply for lead removal in industrial applications.
Evaluating sea cucumbers as extractive species for benthic bioremediation in mussel farms
Authors: Grosso Luca , Rampacci Massimo , Pensa Davide , Fianchini Alessandra , Batır Esin , Aydın İlhan , Ciriminna Laura , Felix Pedro M. , Pombo Ana , Lovatelli Alessandro , Vizzini Salvatrice , Scardi Michele , Rakaj Arnold 
Published: January 2023

AbstractFilter-feeding mussels blend suspended particles into faeces and pseudo-faeces enhancing organic matter flows between the water column and the bottom, and strengthening benthic-pelagic coupling. Inside operating farms, high bivalve densities in relatively confined areas result in an elevated rate of organic sinking to the seabed, which may cause a localized impact in the immediate surrounding. Deposit-feeding sea cucumbers are potentially optimal candidates to bioremediate mussel organic waste, due to their ability to process organic-enriched sediments impacted by aquaculture waste. However, although the feasibility of this polyculture has been investigated for a few Indo-Pacific species, little is known about Atlanto-Mediterranean species. Hence, for the first time, in the present study, we conducted a comparative investigation on the suitability of different Mediterranean sea cucumber species, to be reared in Integrated Multitrophic Aquaculture (IMTA) with mussels. A pilot-scale experiment was accomplished operating within a mussel farm where two sea cucumbers species,Holothuria tubulosaandHolothuria polii, were caged beneath the long-line mussel farm ofMytilus galloprovincialis. After four months,H. tubulosashowed high survivorship (94%) and positive somatic growth (6.07%); converselyH. poliishowed negative growth (− 25.37%), although 92% of specimens survived. Furthermore, sea cucumber growth was size-dependent. In fact, smaller individuals, independently from the species, grew significantly faster than larger ones. These results evidenced a clear difference in the suitability of the two sea cucumber species for IMTA withM. galloprovincialis, probably due to their different trophic ecology (feeding specialization on different microhabitats, i.e. different sediment layers). Specifically,H. tubulosaseems to be an optimal candidate as extractive species both for polycultures production and waste bioremediation inM. galloprovincialisoperating farms.
Noni fruit extract ameliorates alcohol-induced hangover symptoms by reducing the concentrations of alcohol and acetaldehyde in a Sprague Dawley rat model and a human intervention study
Authors: Kim Kyeong Jin , Park Soo-yeon , Park Tae gwon , Park Hyeon-Ju , Kim Young-Jun , Kim Eun Ji , Shin Wonsuk , Kim Anhye , Yoo Hyounggyoon , Kweon MinSon , Jang Jihwan , Choi Su-Young , Kim Ji Yeon 
Published: January 2023

Noni fruit extract alleviates hangover caused by alcohol comsumption through increasing the activities of ADH and ALDH.
Recent Developments in Vestibular Migraine: A Narrative Review
Authors: Benjamin Tania , Gardi Adam , Sharon Jeffrey D. 
Published: January 2023

Purpose:
The aim of this study was to review current literature regarding the epidemiology of vestibular migraine (VM), patient presentation, pathogenesis, and treatment.

Recent Findings:
VM is becoming an increasingly recognized condition in the United States, currently affecting 2.7% of people. Patients may experience vestibular symptoms, such as vertigo and imbalance, with or without other migrainous symptoms. Recent evidence has also shown that patients with VM are at higher risk for cochlear dysfunction, such as sudden deafness, sensorineural hearing loss, and tinnitus. The heritability and genetics are not well understood, and the pathogenesis may involve calcitonin gene-related peptide, which is also implicated in migraine headaches. A disease-specific patient reported outcome measure, the Vestibular Migraine Patient Assessment Tool and Handicap Inventory, was recently developed and validated. A limited number of controlled trials have assessed various therapies for VM, including triptans and beta-blockers. More data are needed to understand whether or not currently available migraine treatments are effective for VM.

Summary:
VM is a common etiology of vertigo and dizziness, presenting with a characteristic spectrum of symptoms. Early data suggest that migraine treatments may be helpful in some cases.
Deep learning based carbon emissions forecasting and renewable energy's impact quantification
Authors: Mujeeb Sana , Javaid Nadeem 
Published: January 2023

AbstractGlobal warming is one of the most challenging issues of the current era. Revolutions in industrial, Information and Communication Technology (ICT) sectors significantly contribute in increasing global warming. Green House Gases (GHG) emissions from industrial, transportation, power and other sectors cause environmental pollution, which results in climate degradation. Environmental experts are well aware of the disastrous consequences of excessive global warming; therefore, several decarbonization strategies are developed and practiced in the recent past. A widely practiced decarbonization strategy is replacing fossil fuels by Renewable Energy Sources (RES) in the power systems. Electricity consumers are also encouraged to shift their consumption load to low carbon emissions' time periods. For accomplishing this task, an estimation of future carbon emissions is required. In this paper, power system's carbon emissions are predicted accurately with the help of a novel and an efficient forecasting model. The proposed model comprises of Spearman Correlation Analysis (SCA) and Improved Shallow Denoising Autoencoder (ISDAE) based feature engineering. Forecasting is performed through an Improved Particle Swarm Optimization (IPSO) based Deep Neural Network (DNN) forecaster. In addition, a comprehensive quantification analysis is also presented in this paper. The impacts of RES integration level on the electricity price, consumption cost and Greenhouse Gases (GHG) emissions are quantified descriptively and graphically. Performance of the proposed forecasting model is evaluated by Normalized Root Mean Square Error (NRMSE), Mean Absolute Error (MAE) and Mean Square Error (MSE). Simulation results prove that the proposed model outperforms Support Vector Machine (SVM) and Multiple Linear Regression (MLR) based carbon emission forecasting models in terms of forecasting accuracy.