bluuebunny/crossref_metadata_2025_split huggingface dataset:
Początki polskiej pieśni kościelnej i jej tematyka
Authors: Garnczarski Stanisław 
Published: January 2023

Polska pieśń kościelna, jednogłosowa i przeznczona dla ludu, stanowi ważny element wielkiego dziedzictwa kultury religijnej Kościoła w Polsce. Jej pojawienie się było w badaniach naukowców wyjaśniane przez wiele teorii. Powszechnie przyjmuje się, że powstała najprawdopodobniej w XIII wieku. Pierwsza badana teoria wywodzi ją z tzw. kierleszu, fonetycznie przekształconej krótkiej formuły Kyrie eleison, śpiewanej przy różnych okazjach. Jednakże, poza kilkoma przypadkami, nie słyszy się w Polsce nic o „kierleszu”. Preferowanym przez Feichta, przeciwnika teorii kierleszowej, źródłem polskiej pieśni jest wprowadzenie odmawiania w języku polskim pacierza w każdą niedzielę i święto, zaraz po odczytaniu Ewangelii. Jednakże można uznać te praktyki jako wstępny etap torujący drogę dla polskiej pieśni. Dominującą teorią jest ta, mówiąca, że źródłem pieśni w Polsce jest łacińska hymnodia, tłumaczona mniej lub bardziej wiernie na język polski. Powstanie polskiej pieśni religijnej wynikało przede wszystkim z zapotrzebowania wiernych na nie w obrzędach religijnych, zarówno pozaliturgicznych, jak i w samej liturgii. Pierwsze pieśni w języku polskim reprezentowały pieśni wielkanocne, pasyjne oraz maryjne.
Sadchikov Pavel E. Features of Molecular Sensitisation Profile in Infants with Risk of Allergic Diseases
Authors: Belyayeva Irina A. , Turti Tatyana V. , Namazova-Baranova Leyla S. , Bombardirova Elena P. , Vishneva Elena A. , Kaytukova Elena V. , Efendieva Kamilla E. , Shukenbaeva R. A. , Sadchikov Pavel E. 
Published: January 2023

Background. For now, there is little data on sensitivity features to specific allergen antigens in infants with initial allergy manifestations.Objective. The aim of the study is to determine the features of the primary molecular sensitisation profile in infants with risk of atopic disease according to their postnatal age.Methods. Full-term infants with burdened familial allergic history and/or skin/gastrointestinal allergy symptoms were examined: Group 1 — 50 children, age — 2.0 [1.0–3.0] months; Group 2 — 35 children, age — 9.0 [8.0–11.0] months.Results. The hereditary atopy risk was observed in 74% of cases (37/50) in Group 1 and in 71% of cases (25/35) in Group 2. 38% of children (19/50) in Group 1 were breastfed, in Group 2 — 60% of children (21/35). Supplemental feeding was implemented in 5.5 [5.0–6.0] months. Sensitisation was reported in 10% and 37% of children. Children of Group 1 were sensitised to food allergen antigens: cow's milk/meat (Bos d 6, Bos d 8), egg-white (Gal d 1, Gal d 2, Gal d 3), soybeans (Gly m 6), shrimps (Pen m 4); airborne allergens: house dust mite (Blo t 5, Der h 10), Anisakidae (Ani s 3), cockroach (Bla g 7). Children of Group 2 were sensitised to food allergen antigens: cow's milk (Bos d 6), egg-white (Gal d 1, Gal d 2), soybeans (Gly m 6), peanut (Ara h 1, Ara h 2, Ara h 6), kiwi (Act d 1), corn (Tri a 19); airborne allergens: cat (Fel d 1, Fel d 4), birch pollen (Bet v 1). Polyvalent sensitisation was revealed in 4% and 6% of cases, respectively.Conclusion. Infants have much wider range of allergens to which they are sensitive than it is commonly believed. Beside obligate food allergens, sensitisation can be caused by airborne allergens: house dust mites, epidermal, birch pollen; crossreactive component — tropomyosin.
Exclusión de la pena en el actuar del llamado drogodependiente en México
Authors: Flores López Pamela Ruiz , Castro Coria Eva Grissel 
Published: January 2023

Este trabajo examina —utilizando el análisis documental y la entrevista semi estructurada— algunos criterios de establecimiento de dependencia a drogas ilegales en México, para luego establecer los juicios que desde la perspectiva de la teoría del delito encuadrarían a inculpados por delitos de posesión y narcomenudeo en supuestos de estado de necesidad y falta de autonomía de la voluntad, de forma que se ofrezca un medio de defensa ante las actuales medidas desproporcionadas. Los resultados ofrecen una serie de criterios jurídicos contradictorios con losinstrumentos estudiados, así como una aparente falta de pruebas psicológicas en la determinación de dependencia en los inculpados. Se concluye que las concepciones jurídicas sobre dependencia a drogas requieren de una actualización que responda a los nuevos hallazgos en el área y que, mientras dicha actualización no exista, todo medio de defensa debe utilizarse para minimizar los efectos desproporcionados de las políticas actuales.
De la justicia social a la justicia compasiva: los aportes de Martha Nussbaum a la filosofía política
Authors: Pinedo Cantillo Iván Alfonso , Yáñez Canal Jaime 
Published: January 2023

Martha Nussbaum es fundamentalmente una filósofa política y moral que, cimentada en la tradición aristotélica, ha logrado integrar en unapostura teórica una visión de la justicia social con una perspectiva sobre la naturaleza y el cultivo de ciertas emociones morales que resultan apropiadas para edificar una nueva ciudadanía democrática. Para nuestra autora, la justicia no puede estar desligada del accionar de las personas en la vida cotidiana, por tanto, considera que este vínculo se puede materializar mediante el cultivo de las emociones, las cuales se entienden como elementos claves de la vida moral que afinan nuestra percepción del mundo y orientan nuestras elecciones. Guiados por esta noción, en este artículo presentamos algunos aspectos fundamentales del pensamiento político de Nussbaum, mostrando la transición que la autora experimenta en sus teorías desde las posturas del liberalismo de Rawls hasta consolidar su propia visión de la “justicia compasiva”, la cual es unaforma concreta de apuntalar la norma pública que defiende cómo todas las personas merecen igual respeto y dignidad. En este recorrido igualmente reflexionaremos sobre la influencia de las posturas comunitaristas de finales del siglo XX en los ideales de ciudadanía de la filósofa de Chicago.
Entre el origen y la pertenencia: consideraciones de Gadamer y Octavio Paz sobre el lenguaje de la poesía
Authors: Ruiz Pulgarín Yulieth Estefanía 
Published: January 2023

Este trabajo parte de la premisa de que, en El arco y la lira, Octavio Paz hace una reflexión acerca del lenguaje poético que se aproxima en diversos aspectos a la hermenéutica de Hans-George Gadamer. En ambos autores encontramos la idea de que la poesía es un lenguaje originario que, por su carácter creador, nos separa de las relaciones habituales del mundo, al mismo tiempo que nos conecta con la tradición. La poesía deviene, así, como una experiencia de origen y de pertenencia: nos lleva a lo que nunca antes habíamos contemplado (experiencia de la otredad y de lo indeterminado), pero también nos conecta con la historia y con la tradición que está presente en toda lengua. Así, el propósito de este trabajo es mostrar los puntos de encuentro entre ambos autores, que, desde puntos de partida muy diferentes, han llegado a planteamientos bastante compatibles entre sí, lo cual se explica, en buena medida, por el hecho de que ambos han superado la visión del lenguaje como medio y han afirmado la esencia lingüística de la poesía.
The EFL Undergraduate Students and English Reading Styles: Evidence from One English Education Program
Authors: Fortunasari Fortunasari , Ali Rd. M. , Lestari Lili , Harja Harlina , Sari Siti Rahma , Hidayati Sri 
Published: January 2023

The study was aimed to investigate the students’ English reading learning styles used by EFL undergraduate students. The participants were students from one English study program at Faculty Teacher Training and Education in Jambi, which aims to produce teachers in English teaching. This study used total sampling with 75 participants consisting of 22 participants in the second semester, and 53 participants in the sixth semester. The analysis of the data was based on the students’ response to twenty five statements that consist of five parts: there are auditory, kinesthetic, group, visual, and individual. For which they were required to choose any of five alternatives namely strongly agree, agree, not sure, disagree, and strongly disagree. The results revealed that the most preferred reading learning style among the respondents was the auditory learning style and the least is visual learning style. Then, for the gender male used kinesthetic learning style and female used auditory learning style. In this study, suggestions for future research, students, lectures and university are also discussed.
Aquisição alimentar por titulares do programa bolsa família
Authors: Correia Alessandra Layara de Sousa , Conceição Jullie Anny da , Lima Maria Edna Rodrigues de , Alberto Norma Sueli Marques da Costa , Pereira Theonas Gomes 
Published: January 2023

É responsabilidade dos governantes criar e implementar políticas públicas que promovam a segurança alimentar e nutricional da população, notadamente dos grupamentos expostos à pobreza. Um dos programas criados pelo governo brasileiro para auxiliar nesse cenário foi o Bolsa-Família. Esta pesquisa objetivou avaliar a contribuição do Programa Bolsa Família (PBF)para aquisição de alimentos por beneficiários. Trata-se de um estudo transversal descritivo, realizado junto aos beneficiários do PBF atendidos em uma Unidade Básica de Saúde da cidade de Teresina(Piauí). Os instrumentos utilizados para a coleta de dados foram dois formulários aplicados junto a 202 adultos, responsáveis pela aquisição de alimentos para a família, que aceitaram participar da pesquisa espontaneamente. A pesquisa seguiu os aspectos éticos recomendados pela resolução no 466/2012. O cenário encontrado revela que 78,7% das famílias recebiam o benefício há mais de um ano; 70,3% residiam em casa própria; 33,1% dividiam o domicílio com quatro ou mais pessoas; 68,8% possuíam renda inferior a um salário mínimo e 52,5% destinavam o benefício para a alimentação, associado a outros gastos. Observou-se que a frequência predominante de aquisição dos alimentos foi na seguinte ordem: mensal, semanal e quinzenal. O grupo alimentar com maior número de aquisição foi o composto por alimentos in natura ou minimamente processados, seguido dos ingredientes culinários processados. Para os grupos de alimentos processados e ultraprocessados foram observadas baixas frequências, em todas as categorias de aquisição (mensal, semanal e quinzenal). Conclui-se que o programa possui importante contribuição para aquisição de itens alimentares, especialmente de itens de primeira necessidade.
Faktor-Faktor Yang Mempengaruhi Audit Report Lag Serta Dampaknya Terhadap Trading Volume Activity
Authors: Amrizal  , Damayanti Fina 
Published: January 2023

ABSTRACT
This study was conducted to analyze the factors that affect audit report lag and its impact on trading volume activity. This research is divided into 2 models, the first is used to find out how leverage, company size, and KAP size affect audit report lag and the second is used to find out how audit report lag influences trading volume activity. The population in this study are mining sector companies listed on the Indonesia Stock Exchange for the 2015-2020 period with a sample of 6 companies taken by purposive sampling method. This study uses multiple linear regression analysis and shows the results that in the first model leverage and KAP size have a negative effect on audit report lag, while company size has no effect on audit report lag. In the second model, audit report lag affects trading volume activity.
Enhanced Deep Learning Frame Model for an Accurate Segmentation of Cancer Affected Part in Breast
Authors: Dewangan Kranti Kumar , Sahu Satya Prakash , Janghel Rekhram 
Published: January 2023

Abstract
Breast cancer is one of the primary causes of death occurring in females around the world. So, the recognition and categorization of breast cancer in the initial stage is necessary for helping the patients to have suitable action. In this research, a novel Spider Monkey-based Convolution Model (SMCM) is developed for detecting breast cancer cells in an early stage. Here, breast Magnetic Resonance Imaging (MRI) is utilized as the dataset trained to the system. Moreover, the developed SMCM function is processed on the breast MRI dataset to primarily detect and segment the affected part of breast cancer. Additionally, segmented images are utilized for tracking in the dataset that has identified the possibility of breast cancer. Moreover, the simulation of this approach is done by Python tool and the parameters of the current research work are evaluated with prevailing works. Hence, the outcomes show that the current research model produces improved accuracy for breast cancer segmentation than other models.
Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma
Authors: Islam Syed , Qassem Khawlah , Islam Shafiqul , Parag Rashed , Rahman Mohammad , Farhat Walid , Yeger Herman , aboussekhra Abdelilah , Karakas Bedri , Noman Abu Shadat 
Published: January 2023

Abstract
Keap1 mutations regulate Nrf2 activity and lead to chemoresistance in cancers. Yet the underlying molecular mechanisms of chemoresistance are poorly explored. By focusing and genotyping head and neck squamous cell carcinoma (HNSCC) that had available pathologic and clinical data, we provide evidence that Keap1 displays frequent alterations (17%) in HNSCC. Functional loss of Keap1 results in significant activation of Nrf2 and promotes cancer cell growth, proliferation, and elevated cancer stem cell (CSCs) self-renewal efficiency and resistance to oxidative stress. Furthermore, decreased Keap1 activity in these cells increased nuclear accumulation of Nrf2 and activation of the Notch pathway, causing enhanced transcriptional alterations of antioxidants, xenobiotic metabolism enzymes, and resistance to chemotherapeutic treatment. Limiting the Nrf2 activity by either Keap1 complementation or by Nrf2 silencing increased the sensitivity to chemotherapy in Keap1-mutated cells and repressed the CSC self-renewal activity. Our findings suggest that Keap1 mutations define a distinct disease phenotype and the Keap1-Nrf2 pathway is one of the leading molecular mechanisms for clinical chemotherapeutic resistance. Targeting this pathway may provide a potential and attractive personalized treatment strategy for overcoming chemotherapeutic resistance conferred by Keap1 mutations.
In-Vivo and In-silico Studies Revealed the Molecular Mechanisms of Colocasia esculenta Phenolics as Novel Chemotherapy against Benign Prostatic Hyperplasia via inhibition of 5α‒Reductase and α1-Adrenoceptor.
Authors: Tusubira Deusdedit , Munezero Jonasi , Agu Peter Chinedu , Ajayi Clement Olusoji , Oloro Joseph , Namale Nathiim , Ssedyabane Frank , Nakiguli Caroline Kiwanuka , Adegboyega Abayomi E. , Aja Patrick Maduabuchi 
Published: January 2023

Abstract
Benign Prostatic Hyperplasia (BPH) is a major cause of lower urinary tract infections and erectile dysfunction thus a major contributor to lowering the quality of life among older men. In this study, we investigated the molecular mechanism of Colocasia esculenta (CE) as a novel agent for BPH chemotherapy. In Vivo, we assigned 45 male Wistar albino rats about 6 weeks old into 9 experimental groups (n=5). BPH was induced in groups 2-9 with 3 mg/kg of Testosterone Propionate (TP) subcutaneously. Group 2 (BPH) was not treated. Group 3 was treated with 5mg/kg Finasteride (standard drug). Group 4-9 were treated each with 200 mg/kg body weight (b.w) of CE crude tuber extracts/fractions (ethanol, hexane, dichloromethane, ethyl acetate, butanone, aqueous). At the end of treatment, we sampled the rats’ serum to check the level of PSA. In Silico, we conducted a molecular docking of the crude extract of CE phenolics (CyP) previously reported, targeting 5α‒Reductase and α1-Adrenoceptor linked to the BPH progressions. We adopted the standard inhibitors/antagonists (5α‒reductase: finasteride; α1-adrenoceptor: tamsulosin) of the target proteins as controls. Furthermore, the pharmacological properties of the lead molecules were studied in terms of ADMET using swissadme and pKCSM resources, respectively. Results showed that administration of TP in male Wistar albino rats significantly (p<0.05) elevated serum PSA levels whereas CE crude extracts/fractions significantly (p<0.05) lowered the serum PSA level. Also, fourteen of the CyPs bind to at least one or two of the target proteins with their binding affinity of between -9.3 to -5.6 Kcal/mol and -6.9 to -4.2 Kcal/mol, respectively. The CyPs possess better pharmacological properties compared to the standard drugs. Therefore, they have the potentials to be enlisted for clinical trials towards the management of BPH.
Clinical utility of overviews on adverse events of pharmacological interventions
Authors: Sachse Thilo , Kanji Salmaan , Thabet Pierre , Schmiedl Sven , Thürmann Petra , Guirguis Fadi , Sajwani Shellyza , Gauthier Marie-France , Lunny Carole , Mathes Tim , Pieper Dawid 
Published: January 2023

Abstract
Background
Overviews (i.e., systematic reviews of systematic reviews, meta-reviews, umbrella reviews) are a relatively new type of evidence synthesis. Among others, one reason to conduct an overview is to investigate adverse events (AEs) associated with a healthcare intervention. Overviews aim to provide easily accessible information for healthcare decision makers including clinicians. We aimed to evaluate the clinical utility of overviews investigating AEs.
Methods
We used a sample of 27 overviews exclusively investigating drug-related adverse events published until 2021 identified in a prior project. We defined clinical utility as the extent to which overviews are perceived to be useful in clinical practice. Each included overview was assigned to one of seven pharmacological experts with expertise on the topic of the overview. The clinical utility and value of these overviews was determined using a self-developed assessment tool. This included four open-ended questions and a ranking of three clinical utility statements completed by clinicians. We calculated frequencies for the ranked clinical utility statements and coded the answers to the open-ended questions using an inductive approach.
Results
The overall agreement with the provided statements was high. According to the assessments, 67% of the included overviews generated new knowledge. In 93% of the assessments, the overviews were found to add value to the existing literature. The overviews were rated as more useful than the individual included systematic reviews (SRs) in 85% of the assessments. The answers to the open-ended questions revealed two key aspects of clinical utility in the included overviews. Firstly, it was considered useful that they provide a summary of available evidence (e.g., along with additional assessments, or across different populations or in different settings that have not been evaluated together in the included SRs). Secondly, it was found useful if overviews conducted a new meta-analysis to answer specific research questions that had not been answered previously.
Conclusions
Overviews on drug-related AEs are considered valuable for clinical practice by clinicians. They can make available evidence on AEs more accessible and provide a comprehensive view of available evidence. As the role of overviews evolves, investigations such as this can identify areas of value.
Mapping out a One Health model of antimicrobial resistance in the context of the Swedish food system: A literature scan
Authors: Cousins Melanie , Parmley E. Jane , Greer Amy L. , Neiterman Elena , Lambraki Irene A. , Vanderheyden Matthew N. , Wernli Didier , Jorgensen Peter Søgaard , Carson Carolee A. , Majowicz Shannon E. 
Published: January 2023

Abstract

Background: Antimicrobial resistance (AMR) causes worsening health, environmental, and financial burdens. Modeling complex issues such as AMR can help clarify the behaviour of the system and assess the impacts of interventions. While models exist for specific AMR contexts (e.g. on-farm, in hospital), due to inadequate collaboration and data availability, how well such models cover the broader One Health system is unknown. Our study aimed to identify models of AMR across the One Health system with a focus on the Swedish food system (objective 1), and data to parameterize the models (objective 2), to ultimately inform future development of a comprehensive model of possible AMR emergence and transmission across the entire system.
Methods: Using a previously developed causal loop diagram (CLD) of factors identified as important in the emergence and transmission of AMR in the Swedish food system, an extensive literature scan was performed to identify models and data from peer-reviewed and grey literature sources. Articles were searched using Google, Google Scholar, and Pubmed, screened for relevance, and the models and data were extracted and categorized in an Excel database. Visual representations of the models and data were overlayed on the existing CLD to illustrate coverage.
Results: A total of 126 articles were identified, describing 106 models in various parts of the One Health system; 54 were AMR specific. Four articles described models with an economic component (e.g. cost-effectiveness of interventions, cost-analysis of disease outbreaks). Most models were limited to one sector (n=60, 57%) and were compartmental (n=73, 69%); half were deterministic (n=53, 50%). Few multi-level, multi-sector models, and models of AMR within the animal and environmental sectors, were identified. A total of 414 articles were identified that contained data to parameterize the models. There were major data gaps for factors related to the environment, wildlife, and broad, ill-defined, or abstract ideas (e.g. human experience and knowledge).
Conclusions: There were no models that addressed the entire system and few that addressed the issue of AMR beyond one context or sector. Existing models have the potential to be integrated to create a mixed-methods model, provided that data gaps can be addressed.
Trim-Away in adult animals through Nano-ERASER and its application in cancer therapy
Authors: Wang Mingming , Wang Junfeng , Wang Yuzhen , Raja Manikanda , Gupta Gourab , Hu Xiangxiang , Shi Shanshan , Chen Hexin , Fan Daping , Xu Peisheng 
Published: January 2023

Abstract
Trim-Away is a versatile intracellular protein degradation pathway that has been extensively explored in vitro. However, the in vivo application of Trim-Away is limited at oocyte and zygote stages due to the lack of an in vivo practical approach for intracellular antibody delivery. To broaden the application of Trim-Away, especially for clinical use, we developed a nanogel-based Nano-ERASER system. Here, we demonstrated that the intracellular delivery of anti-programmed cell death ligand 1 (PD-L1) antibody through Nano-ERASER could effectively deplete PD-L1 in triple negative breast cancer (TNBC) cells and induce cancer cell death. Furthermore, with the help of a tumor tissue-targeted nanogel, anti-PD-L1 antibody-loaded Nano-ERASER effectively inhibited tumor progression in a TNBC mouse model. These results confirmed that Nano-ERASER realized Trim-Away in adult animals for the first time, which could be an effective tool for disease treatment and studying gene/protein function both in vitro and in vivo.