bluuebunny/crossref_metadata_2025_split huggingface dataset:
MOBILE-BASED MULTIDOMAIN LIFESTYLE INTERVENTION AND HEALTH PROMOTION IN OLDER KOREAN AMERICANS
Authors: Kim Junhyoung 
Published: December 2022

Abstract
Prior studies have suggested that the nature-based virtual reality (VR) program serves as a therapeutic tool to increase health and wellbeing among older adults. While much research on virtual reality indicates their health benefits among older adults, there are research gaps in the current literature on the nature-based VR experiences of older Korean Americans. The objective of this study was to gather preliminary information on the health outcomes of the program as well as challenges to participation. Based on in-depth interviews with five participants, three main salient themes as positive outcomes emerged: (a) enjoyment, (b) stress reduction, and (c) cognitive function. On the other hand, there were three main challenges that participants experienced: (a) challenges in the immersion experience itself, (b) difficulties with the controllers, and (c) cybersickness. This finding suggests that the nature-based virtual reality program can serve older immigrant population as a therapeutic tool to increase their mental and cognitive health.
USING REAL-WORLD EVIDENCE TO SUPPORT THE FDA REGULATORY APPROVAL: METHODOLOGICAL CONSIDERATIONS
Authors: Lu Kevin , Slattum Patricia 
Published: December 2022

Abstract
Evidence from clinical trials has traditionally been used to support regulatory drug approval, whereas real-world evidence (RWE) has been used for post-marketing surveillance studies. With the enaction of the 21st Century Cures Act, the Food and Drug Administration (FDA) is evaluating the potential use of RWE to support new indications for an approved product or to satisfy post-approval study requirements. Yet the substantial evidence standard remains unchanged for FDA approval. To date, the FDA has issued guidelines or frameworks for using RWE for regulatory decisions. However, many methodological challenges remain unanswered when using RWE in gerontology research. This Pharmaceutical Care and Outcomes Research Interest Group-sponsored symposium consists of leading experts in the country to address these problems. The four papers in this symposium will address methodological challenges that are unique in gerontology research. Specifically, The first paper will introduce the FDA drug evaluation process, focusing on the key considerations for evaluating RWE in regulatory decision making; the second paper will discuss possible challenges related to data sources from which RWE are generated in aging research; the third paper will provide a case example of some of the challenges in using RWD sources to generate RWE in the Alzheimer’s Disease setting; and the fourth paper will provide recommendations for improving gerontology research based on RWE going forward.
CELL SENESCENCE IS A FEATURE AND MODULATOR OF THE AGED INFLAMMATORY BRAIN CELL LANDSCAPE
Authors: Schafer Marissa , Zhang Xu , Carver Chase , Pearsall Vesselina , Atkinson Elizabeth , Clarkson Benjamin , Grund Ethan , LeBrasseur Nathan 
Published: December 2022

Abstract
New strategies to preserve cognitive function could broadly benefit the aging population. Cellular senescence is a hypothesized mediator of inflammation-related tissue dysfunction in aging. Using single-cell RNA-sequencing, we discovered an age-related brain myeloid population exhibiting overlapping senescent and disease-associated activation signatures, including upregulation of chemoattractant factors. We confirmed senescent brain myeloid cells promote peripheral immune cell chemotaxis in vitro. Through mass cytometry, we demonstrate age- and sex-dependent increases in activated resident and infiltrating brain immune cells are reduced through systemic targeting of p16-positive senescent cells, which is associated with improvements in executive function and spatial learning tasks. Our high-dimensional results reveal dynamic remodeling of the age-dependent brain immune cell landscape and implicate senescent cell targeting as a strategy to counter inflammatory changes and cognitive decline.
AGE-ASSOCIATED GRANZYME K-EXPRESSING CD8+ T-CELLS ENHANCE ATHEROSCLEROSIS IN MICE
Authors: Tyrrell Daniel , Goldstein Daniel 
Published: December 2022

Abstract
A novel population of age-associated Granzyme K (GZMK)-expressing CD8 T cells was found in mice and humans. These cells enhance local tissue senescence and inflammation and are distinct from central memory and conventional Granzyme B- or Interferon γ-producing effector memory CD8 T cells. It is unknown whether these cells drive chronic disease; thus, we induced atherosclerosis in young (3-mo) and aged (18-mo) wild-type mice via the PCSK9-AAV model and used scRNAseq to demonstrate that this GZMK-CD8 T cell population homes to atherosclerotic lesions exclusively in aged mice. Neutralizing CD8 T cells demonstrates that GZMK-CD8 cells drive age-enhance atherosclerosis. Finally, we transferred GZMK-CD8 cells from different aged donors into young CD8-/- hosts and demonstrate that GZMK-CD8 cells from aged but not young donors drive atherosclerosis. In conclusion, we identified a novel role for this recently described population of aging-specific GZMK-expressing CD8+ T cells as a critical driver of chronic disease.
IMPLEMENTATION SCIENCE IN DEMENTIA CARE: METHODOLOGICAL, CULTURAL, AND SOCIODEMOGRAPHIC CONSIDERATIONS
Authors: Gaugler Joseph , Gitlin Laura , Prusaczyk Beth 
Published: December 2022

Abstract
The gap between aging science and practice persists. Getting the best possible evidence into the real world is a particular challenge in gerontology because of the complex needs of older persons, the family caregiving experience, the workforce shortage, and underlying structural concerns with how services for older people are regulated, paid for, and valued. The purpose of this symposium is to consider contextual dimensions to facilitate implementation, methodological considerations, strategies to inform cultural adaptation of evidence-based innovations, and how creativity and innovation in low- and middle-income countries can better inform implementation practices in resource rich countries and vice-versa. Specifically, Dr. Marie Boltz and colleagues will examine the conceptual and theoretical underpinnings of organizational readiness for implementation and the operationalization of the construct. Dr. Joseph Gaugler and co-authors will provide case examples of three “hybrid effectiveness” trials in dementia care in different care settings including community-based and residential long-term care settings, each of which incorporate implementation methods alongside traditional evaluations of effectiveness. Dr. Lauren Parker and her team will demonstrate how cultural adaptation strategies were applied to facilitate the implementation of a community-based, evidence-based dementia care intervention. Dr. Baker and colleagues consider implementation issues and innovations in low- and middle-income countries. Dr. Beth Prusaczyk, an implementation expert, will serve as Discussant and highlight future implementation issues to advance best practices that facilitate and expedite the translation of aging science.
CULTURAL ADAPTATION OF THE ADULT DAY SERVICE PLUS PROGRAM FOR HISPANIC/LATINO DEMENTIA CAREGIVERS
Authors: Parker Lauren , Marx Katherine , Knimbeng Manka , Johnson Elma , Koeuth Sokha , Gaugler Joseph , Gitlin Laura 
Published: December 2022

Abstract
Although Hispanic/Latinos are at disproportionate and increased risk for Alzheimer’s disease and related dementias, few evidence-based supportive care interventions have been specifically developed for or adapted for this population. Adapting a supportive care intervention requires more than Spanish language translation and necessitates an understanding of cultural nuances and care preferences of Hispanic/Latino families and staff who implement the intervention. This paper reports on the cultural adaptation of the Adult Day Service Plus (ADS Plus) intervention for delivery by staff to Hispanic/Latino caregivers which was guided by the Cultural Adaptation Process Model. Also, using the Framework for Reporting Adaptations and Modifications-Enhanced (FRAME),we discuss: 1) when modifications were made, 2) who determined modifications needed, 3) what aspects of the intervention were modified, 4) the relationship to fidelity and how fidelity was maintained, and 5) reasons for modifications. Modifications to the delivery and content were changed to reflect values and norms of both the Hispanic/Latino staff and the caregivers they serve. As supportive interventions for dementia caregivers are developed and implemented into real world settings, inclusion of cultural elements may enhance research participation from Hispanic/Latino provider sites and caregivers. We suggest in this paper that cultural adaptation is an essential consideration in developing an intervention as well as adapting evidence-based previously tested interventions, and in implementation science. Cultural adaptation offers an important lens by which to identify contextual factors impacting intervention adoption interventions and needed adaptations to assure equity in the reach of evidence-based programs.
DEPRESSION AND PAIN PERSEVERANCE THROUGH EMPOWERED RECOVERY (DAPPER) PILOT PROGRAM: A CASE STUDY ON TECHNOLOGY
Authors: Clair Catherine , Melvin Tonisha , Szanton Sarah , Saylor Martha Abshire , Thorpe, Jr. Roland J , Taylor Janiece 
Published: December 2022

Abstract
There is a paucity of work focusing on the engagement of older African American women with technology. The aim of the pilot study was to test the Depression and Pain Perseverance through Empowered Recovery (DAPPER) program in a sample of older African American women living with pain and low mood (N=19). The research team hypothesized that most of the women would prefer virtual visits, thus both in-person and virtual options were available for program delivery. So far, of 11 participants, five women have opted to do in-person visits. When asked why, one participant said that having the nurse come to her house was “rewarding, [especially] when you live alone.” Another participant commented that she did not have a computer in her home. These findings demonstrate that older adults exist on a spectrum of comfort with and access to technology.
CHALLENGES AND SOLUTIONS FOR MOBILE HEALTH INTERVENTION RESEARCH IN OLDER ADULTS WITH MULTIPLE CHRONIC CONDITIONS
Authors: Lukkahatai Nada , Junxin Li 
Published: December 2022

Abstract
Advances in smart phone technologies resulted in exponential growth in the use of mobile technology in health care. The mobile health or mHealth became a tool in engaging patients in self-care, monitor symptoms and provider-patients communication. Older adults living with Multiple Chronic Conditions (MCCs) are required to self-manage their complex conditions. These health demands are greater in low-income older adults. The mHealth can be beneficial in supporting health and increase access to care for this population. Our study examined a feasibility of combination of the mHealth and tailored exercise program for low SES older adults. We found that age-related physical and cognitive decline, acceptance of technology, complexity of user interface, and financial burden hinder the benefit and accessibility of the mHealth. The research team purpose solutions include improve user interface, create training session and technical support, provide incentives and technology and involve caregivers for these challenges.
RECRUITMENT OF SOMMA PARTICIPANTS: TECHNIQUES TO ENROLL OLDER ADULTS IN A COMPLEX STUDY
Authors: Newman Anne , Cawthon Peggy , Mau Theresa , Kritchevsky Stephen , Hepple Russell T , Coen Paul , Goodpaster Bret , Cummings Steven 
Published: December 2022

Abstract
We screened approximately 4200 individuals to enroll 881 including 41% men and 59% women with a mean age =73.4 ± 5SD years; 13% were Black, 85% White and 2% of other race and ethnic groups. We will add 80 individuals aged 30-69 years. Exclusions included unstable medical conditions and inability to walk 400 meters(m). The median baseline 400m gait speed at usual pace was 1.05 ± 0.18SD m/s. Techniques to recruit and enroll a diverse population for this complex project included the use of in-person and video-conference information sessions to explain the complicated study to interested adults and to screen potential participants as needed The COVID pandemic created numerous challenges; while SOMMA was able to meet its recruitment goals, the enrollment period lasted 33 months (instead of the originally planned 18 months). Attendance at follow-up in-person and phone-based assessments is excellent.
JOSEPH T. FREEMAN AWARD AND EXCELLENCE IN REHABILITATION OF AGING PERSONS AWARD PRESENTATIONS AND LECTURES
Authors: Brown Cynthia 
Published: December 2022

Abstract
The Joseph T. Freeman Award lecture will feature an address by the 2022 Freeman Award recipient Neil M. Resnick, MD, FGSA, of the University of Pittsburgh. The Joseph T. Freeman Award is a lectureship in geriatrics awarded to a prominent clinician in the field of aging, both in research and practice. The award was established in 1977 through a bequest from a patient's estate as a tribute to Dr. Joseph T. Freeman. The Excellence in Rehabilitation of Aging Persons Award lecture will feature an address by the 2022 Excellence in Rehabilitation Award recipient Patricia C. Heyn, PhD, FGSA, FACRM, of Marymount University. The Excellence in Rehabilitation of Aging Persons Award is designed to acknowledge outstanding contributions in the field of the rehabilitation of aging individuals.
REFLECTION AND INTENTION: END-OF-LIFE PLANNING IN FORMER CAREGIVERS OF PARENTS LIVING WITH DEMENTIA
Authors: Mroz Emily , Matta Tara , Ali Talha , Piechota Amanda , Abboud Anissa , Sharma Shubam , Monin Joan , Fried Terri 
Published: December 2022

Abstract
Family caregivers for parents living with Alzheimer’s Disease or Related Dementias (ADRD) provide support through health decline, care planning, and death. Guided by the Consensual Qualitative Research method and grounded in a life story framework, this study examines recalled caregiving experiences and descriptions of personal end-of-life planning in 32 midlife former caregivers of parents with ADRD (range: 40-65; 44% male). Former caregivers often expressed appreciation for end-of-life planning but varied in their engagement in planning since their loss. Descriptions of hesitation with planning were rooted in salient challenges from caregiving experiences and reflected relational concerns (e.g., about burdening others with care needs), planning complexity (e.g., perceiving too many factors to account for), or mortality denial (e.g., aversion to thinking more about death). These caregiving experiences may clarify the value of end-of-life planning while, in some cases, impeding decision-making, leading to gaps between former caregivers’ planning intentions and engagement.
REIMAGINING ADVANCE CARE PLANNING: FORMER CAREGIVERS OF AFRICAN AMERICANS WITH DEMENTIA PERSPECTIVES
Authors: Miller Emika , Moss Karen , Wright Kathy , Wilson-Lawson Kimberly , Happ Mary Beth , Rose Karen , Monroe Todd , Wills Celia 
Published: December 2022

Abstract
Advance care planning disparities persist among lower socioeconomic status African American older adults living with dementia despite multiple decades of research. The perspectives of former family caregivers are rarely used in developing effective interventions. This study aims to characterize the advance care planning and other health-related decision-making perspectives of former family caregivers of African Americans who lived with dementia. This qualitative study is part of an ongoing mixed-methods study to co-create a culturally tailored advance care planning intervention. Former caregivers (n=11) participated in semi-structured interviews and identified the following needs: Caregiver education, caregiver recognition by healthcare providers, and removal of caregiving obstacles. Participants also acknowledged their need to restore identity following the death of their care recipient and a desire to assist other caregivers through research participation. This study fills a critical gap by including former caregivers’ perspectives in co-creating a culturally tailored advance care planning intervention.
MIDLIFE CREATIVITY AMONG COMPOSERS AND NOVELISTS
Authors: O'Neill Desmond 
Published: December 2022

Abstract
Although the study of midlife has increased in recent years, it still lags behind study of life at the extremes of age. As a key threshold stage in the lifespan, our understanding can be enhanced by exploration of novelists and composers whose most substantive work began to be produced in midlife. This presentation will draw off the works of midlife works of composers who also composed into later life - Giussepe Verdi, Richard Strauss and Johannes Brahms - from the concert proposed by the Indianapolis Symphony during GSA 2022, as well as reflecting on the works of Anita Brookner as representative of other novelists and poets whose work and careers came to prominence in midlife.
SOCIAL STRESSORS ASSOCIATED WITH AGE-RELATED T LYMPHOCYTE PERCENTAGES IN OLDER US ADULTS: EVIDENCE FROM THE HRS
Authors: Klopack Eric , Crimmins Eileen , Cole Steve , Seeman Teresa , Carroll Judith 
Published: December 2022

Abstract
Exposure to stress is a risk factor for poor health and accelerated aging. Immune aging, including declines in naïve and increases in late memory and terminally differentiated T cells, plays a role in immune health and tissue specific aging, and may contribute to elevated risk for poor health among those who experience high psychosocial stress. Past data have been limited in estimating the contribution of life stress to the development of accelerated immune aging and investigating mediators such as lifestyle and CMV infection. This study utilizes a national sample of 5744 US adults over age 50 to assess the relationship of social stress (viz., everyday discrimination, stressful life events, lifetime discrimination, life trauma, and chronic stress) with flow cytometric estimates of immune aging, including naïve and terminally differentiated T cell percentages and the ratio of CD4+ to CD8+ cells. Experiencing life trauma and chronic stress was related to a lower percentage of CD4+ naïve cells. Discrimination and chronic stress were each associated with a greater percentage of terminally differentiated CD4+ cells. Stressful life events, high lifetime discrimination, and life trauma were related to a lower percentage of CD8+ naïve cells. Stressful life events, high lifetime discrimination and chronic stress were associated with a higher percentage terminally differentiated CD8+ cells. High lifetime discrimination and chronic stress was related to a lower CD4+:CD8+ ratio. Lifestyle factors and CMV seropositivity partially reduced these effects. Results identify psychosocial stress as a contributor to accelerating immune aging by decreasing naïve and increasing senescent T cells.
ADAPTING THE ECHO MODEL TO MEET THE NEEDS OF RURAL DEMENTIA CAREGIVERS
Authors: Schenck Sabine , Carrico Catherine , Carling Stacy 
Published: December 2022

Abstract
Caring for an individual with dementia may result in caregiver stress and burden (Cassie & Sanders, 2008), which can lead to detrimental health outcomes if not managed with effective coping skills and support (Shulz & Martire, 2004). Access to support and psychoeducation is limited in rural and frontier communities, and solutions are needed to reach caregivers across sparsely populated regions. Project ECHO (Extension for Community Health Outcomes) is an evidence-based model designed to improve patient outcomes through healthcare provider education. The Wyoming Dementia Together Caregiver Network is the first of its kind to adapt the ECHO model for family caregivers of persons with dementia. This presentation details evaluation results of 24 session across 52 weeks (n=162). Results suggest that adaptation of Project ECHO for family caregivers is feasible and palatable. In addition, the adapted program shows promise for improving caregiver outcomes such as depressive symptoms and caregiver burden.
CONNECTING THE DOTS: CHRONIC CARE MANAGEMENT PROGRAM IMPLEMENTATION IN RURAL PRACTICES
Authors: Jones Faith , Franke Kevin , Woods Tonja , Bjore Emma , Punke Elizabeth 
Published: December 2022

Abstract
As the focus of healthcare changes from a “sick” care model to a population health model, primary care and specialty clinic practices have new opportunities supported through Medicare reimbursement. The incorporation of team-based care coordination programs into clinic practices is an important step towards value-based care and achieving the Triple Aim: better health for the population, better care for individuals, and lower costs through improvements. Since 2019, six rural Wyoming primary care practices have completed training to implement and expand care coordination programs. HealthTechS3 provides participating clinics with team-based training in the implementation of the Chronic Care Management Program, Behavioral Health Integration, and other billable care coordination services. To date, 301 patients have enrolled in care coordination services. These practices have generated $350,000 in revenue. Using a consolidated implementation framework as a guide, critical components of successful rural care coordination program implementation are discussed.
REIMAGINING AGING: LESSONS ON HEALTHY AGING FROM AARP
Authors: Keenan Teresa , Lampkin Cheryl 
Published: December 2022

Abstract
This presentation will include insights on healthy aging based on data obtained from multiple recent AARP surveys fielded among nationally representative samples of midlife and older adults. Samples were weighted to reflect population estimates (i.e., gender, ethnicity, etc.). Studies also included oversamples of Black/African American and Hispanic/Latino respondents when possible, enabling enhanced analyses. This multi-analysis presentation will provide valuable insights on healthy aging in general, the impact the COVID-19 pandemic has had on the older populations’ ability to maintain healthy habits, and how our “new normal” suggests the need to reimagine healthy aging. This presentation will showcase exciting new findings from AARP Research on diet, exercise, resiliency, and mental health, among others. Augmented with qualitative data, this presentation will also allow participants to hear the voices of older adults on these issues. Additionally, new data collected in late fall 2022 will provide a preview of up-to-the-minute insights.