bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between cognitive capacity and metabolic indices in patients with neuropsychiatric disorders
Authors: Rajabi Fatemeh , Rahimi Somayyeh , Maracy Mohammad R. , Barekatain Majid 
Published: September 2023

BACKGROUND:
Although previous studies suggested the relationship between metabolic indices and cognitive capacity, results have been conflicting. The prevalence of metabolic and cognitive disorders is high in patients with neuropsychiatric disorders. We aimed to assess the relationship between laboratory metabolic indices and specific areas of cognitive capacity.

MATERIALS AND METHODS:
This was a retrospective review of the medical records of 423 from 452 patients with neuropsychiatric disorders who were admitted to the neuropsychiatry unit, Ayatollah Kashani Hospital, Isfahan, Iran, from September 1, 2018, to September 30, 2022. We extracted demographic factors, laboratory metabolic indices, and scores of the Neuropsychiatry Unit Cognitive Assessment tool (NUCOG). We utilized a generalized linear model (GLM) to demonstrate the effect of metabolic indices on the risk of reduction in cognitive domains. Due to the presence of missing data in the metabolic indices, we used the multiple imputation method.

RESULTS:
The regression coefficient of NUCOG total score and subscale scores for metabolic indices using GLM after multiple imputation method demonstrated that among the metabolic indicators, fasting blood sugar (FBS) had the reverse relationship with the total score of NUCOG (β = -.05). Among the NUCOG subscales, executive functioning had the strongest relationship with FBS (β = -.01). Also, there was a negative relationship between patients' age and the total score of NUCOG (β = -.38). Educational level had a positive relationship with the total NUCOG score (β =10.2).

CONCLUSIONS:
The main metabolic factors that might reduce cognitive capacity were higher FBS.
Effects of Patient and Seizure-Related Factors on Drug Load in Seizure-Free Patients with Idiopathic Generalized Epilepsy
Authors: Eren Fulya , Gül Günay 
Published: September 2023

Introduction:
Idiopathic generalized epilepsies (IGEs) include four different epilepsy syndromes and IGE have mostly a good response to antiepileptic drugs (AEDs). The most common IGE subgroup is juvenile myoclonic epilepsy (JME). It generally responds well to low doses of AEDs; however, some patients need higher doses of medication. In this study was hypothesized that patient and epilepsy characteristics of seizure-free patients with high drug load might differ from those with low drug load. For this purpose, it was aimed to compare patients with JME and patients with other generalized epilepsies (non-JME IGE) regarding these factors concerning drug load.

Patients and Methods:
The records of the epilepsy outpatient clinic from 2010 to 2020 were retrospectively evaluated for patients with IGEs. Patients without any epileptic seizures in the last year were accepted as seizure-free. Drug load is calculated by dividing the prescribed daily dose by defined daily dose (PDD/DDD). A total drug load (TDL) equal to one and greater was considered as a high TDL (≥1, high-TDL group), where a drug load of below one was considered as a low TDL (<1, low-TDL group). The high-TDL and low-TDL groups in patients with JME and non-JME IGE were compared in terms of sociodemographic characteristics, personal and family histories, duration of epilepsy, seizure characteristics, epilepsy syndromes, electroencephalography findings, and AEDs and doses.

Results:
In this study, 119 patients (69 females, 50 males) with a mean age of 30.11 (range, 18–65) years were included. The mean age of onset and duration of the disease was 16.21 (range, 3–47) years and 13.6 (1–45) years, respectively. Sixty-three of the patients were diagnosed as having JME, and 56 patients were diagnosed as having non-JME IGE (39 with generalized tonic-clonic seizures alone, 17 juvenile absence epilepsy). According to the TDL, 35 patients were classified in the low-TDL group and 84 patients in the high-TDL group. The age of disease onset was higher in the non-JME IGE group (P = 0.027). Triple-type seizures were significantly more common in the JME group (P < 0.001). No statistically significant differences were found between the low- and high-TDL groups regarding patient and epilepsy characteristics in the JME and non-JME IGE groups.

Conclusion:
Most seizure-free patients had low-TDL in the JME and non-JME IGE groups. No association was observed in the JME and non-JME IGE groups regarding the total AED load.
Long-Term Surgical Outcomes and Predictors of Surgical Treatment in Temporal Lobe Epilepsy
Authors: Yildirim Irem , Gurses Asli Akyol , Ataoglu Esra Erkoc , Kurt Gokhan , Akdemir Umit Ozgur , Oner Ali Yusuf , Hirfanoglu Tugba , Atay Lutfiye Ozlem , Serdaroglu Ayşe , Bilir Erhan 
Published: September 2023

Background:
Surgical treatment of epilepsy is a favored modality in the management of refractory temporal lobe epilepsy (TLE) and known to be quite effective. The aim of this study was to evaluate the long-term outcomes in surgical treatment of TLE and to identify prognostic factors influencing postoperative seizure remission.

Materials and Methods:
The patients who underwent anterior temporal lobectomy (ATL) with the diagnosis of refractory TLE in our center between the years of 2006 and 2020 were included. Preoperative workup process was carried out by a multidisciplinary team and consisted of neuropsychological examination, long-term electroencephalography, brain magnetic resonance imaging (MRI), and fluorodeoxyglucose positron emission tomography (FDG-PET) for each patient. Postoperative assessment of seizure control was repeated every year following surgery and categorized according to Engel's outcome classification. The predictive value of baseline demographic, clinical, laboratory, imaging, and histopathological parameters on postoperative seizure control was also evaluated.

Results:
One hundred and forty-three patients who underwent ATL with the diagnosis of TLE were included. According to Engel's classification, the seizure freedom rate was found to be 83.2% at the 2nd year, 81.3% at the 4th year, and 79.2% at the 10th year after surgery. In the univariate analysis, febrile seizure (FS) history, unilateral interictal epileptiform discharges (IEDs), hippocampal sclerosis (HS) on MRI, unilateral temporal hypometabolism (HM) on FDG-PET, and HS in histopathology were predictors of seizure control at the postoperative 2nd and 10th years. FS history, unilateral localization of IEDs, and unilateral FDG-PET findings of temporal HM were found to be the independent predictors of postoperative seizure control on multivariate analysis.

Conclusions:
In the current study, we revealed that epilepsy surgery provides effective seizure control and represents a beneficial therapeutic option in refractory TLE. Our results also suggested that FS history, unilateral IEDs, and unilateral FDG-PET findings of temporal HM were independent predictors of seizure remission in these patients.
Asymptomatic Median Neuropathy in Patients with Diabetic Polyneuropathy
Authors: Alemdar Murat 
Published: September 2023

Aim:
This study aims to investigate whether asymptomatic median neuropathy (AMN) in patients with diabetic peripheral polyneuropathy (DPNP) is a result of polyneuropathic involvement of median nerve (MN) or its true entrapment.

Subjects and Methods:
We determined the grades of the Michigan severity scale and the rates of peripheral nerve conduction abnormalities in study subgroups, including patients with carpal tunnel syndrome (CTS), AMN, and normal MN conductions to highlight if the severity of polyneuropathic involvement was different between them. In addition, the results of conventional and comparative nerve conduction studies (NCSs) were compared between these study subgroups.

Results:
Distributions of Michigan grades and rates of abnormalities in peroneal and sural NCSs were similar between the subgroups (P > 0.05 for all analyses). Abnormality rates of ulnar NCSs were higher in the AMN group than in the other groups, whereas those of comparative transcarpal NCSs were higher in the CTS group. The mean distal sensory latency (DSL) and motor latency (DML) of MN were longer, sensory conduction velocity (SCV) was slower in the CTS group than AMN group, whereas MN motor conduction velocity (MCV) was slower, UN DSL was longer, SCV was slower, SNAP amplitude was smaller, DML was longer, and MCV were slower in the AMN group (P < 0.05 for all analyses).

Discussion:
Our findings reveal that grade of polyneuropathic involvement is more prominent in AMN, whereas transcarpal MN conduction delay is greater in CTS. The results of the study suggest that the prominence of polyneuropathic impairment in addition to a lesser degree of MN sheet compression obscures the clinical signs in patients with diabetes with AMN.
The Properties of Exosomes Derived from Mesenchymal Stem Cells Preconditioned with L-Ascorbic Acid and Cobalt (II) Chloride
Authors: Barlian Anggraini , Amsar Rizka Musdalifah , Prawitasari Salindri , Wijaya Christofora Hanny , Ana Ika Dewi , Wungu Triati Dewi Kencana 
Published: September 2023

Extracellular vesicles including exosomes, are produced by cells for intracellular communication. Preconditioning of parental cells influences exosome properties. The purpose of this study was to examine the effects of L-ascorbic acid (LAA) and cobalt (II) chloride (CoCl2) on human Wharton’s jelly mesenchymal stem cell (hWJ-MSC)-derived exosomes and their ability to promote stem cell differentiation into chondrocytes. The cells were isolated from the umbilical cord and characterized according to the criteria for mesenchymal stem cell. The cells were cultured in a serum-free medium containing LAA and CoCl2. Cell-produced exosomes were isolated and characterized. hWJ-MSCs can grow in serum-free medium containing LAA and CoCl2. Exosomes derived from hWJ-MSCs had a round morphology, particle size within the exosome range, CD 63 expression, and the capacity to be internalized by cells. The production of exosomes by hWJ-MSCs was enhanced by LAA treatment. LAA and CoCl2 promoted stem cell differentiation into chondrocytes, as indicated by the production of collagen type II and glycosaminoglycans. LAA and CoCl2 affect the properties of MSC-derived exosomes. LAA induces cells to produce exosomes in greater quantities, which have the potential to promote chondrogenic differentiation of stem cells.
Determinants of youth participation in agribusiness activities in Ikwuano Local Government Area, Abia State, Nigeria
Authors: Nnamani N.G. , Obediah C.P. 
Published: September 2023

Young people perceive agriculture as a profession of intense labour, not profitable and unable to support their livelihood compared to what white collar jobs offer. The study was on determinants of youth participation in agribusiness activities in Ikwuano Local Government Area, Abia State, Nigeria. Specifically, the study examined the socio-economic characteristics of youths in the study area; identified various agro-related enterprises participated by the youths and estimated factors that influence youth participation in agro- related enterprises. Random sampling technique was used to select 90 respondents for the study. Data were analyzed using both descriptive statistics and Probit regression model. Majority (62.42%) of the youths were male. Mean age of the respondents was 23 years. About 90% of the youths were single with diverse levels of formal education. The agribusiness enterprises mostly participated in by the youths were animal production (51.1%) and crop production (23.33%). Result of Probit regression showed that age, household size, access to land, non-farm income, empowerment were 1% respectively and sex (5%) were significant variables influencing youth participation in agribusiness activities. It was recommended that youth in the study area enhance their livelihood sources through diversifying into other agro-related enterprises such as sale of agro-inputs and agro-processing.
The phytochemicals, antioxidant activities and nutritive qualities of some selected tomato pastes sold in Umuahia Metropolis, Abia State, Nigeria
Authors: Ukom A.N. , Obikwelu C.L. , Okparauka I.I. , Ogbu O.T. 
Published: September 2023

Tomato paste contains antioxidant compounds which act against free radical actions in the body and prevents oxidative damage and boost the physiological health of consumers. However, information on the phytochemicals, antioxidant activities and nutritive qualities of tomato pastes sold in Umuahia Metropolis is scarce. This work was undertaken to fill this gap on five selected commercial tomato pastes sold in Umuahia Metropolis, Abia State, Nigeria namely, Sonia (SON), Gento (GEN), Superdelicieux (SUP), Star (STA) and Clappa (CLA). The physicochemical and antioxidant activity parameters were determined by standard methods. The results showed that lycopene (4.20 mg 100g‒1 ), vitamin C (12.76 mg 100g‒1 ) and vitamin A (1.43 mg 100g‒1 ) were significantly (p < 0.05) higher in STA tomato paste. β-carotene (3.02 mg 100g‒1 ) and vitamin E (11.14 mg 100g‒1 ) were significantly (p < 0.05) higher in CLA tomato paste, while phenol was significantly (p < 0.05) higher in SUP tomato paste. The chemical composition revealed that total solid ranged from 28.91 (STA) to 31.67% (SON), reducing sugar ranged from 8.78 (SUP) to 16.16% (CLA), while titratable acidity ranged from 0.21 (SON) to 0.31% (GEN) and pH ranged from 4.27 (CLA) to 4.47 (STA), respectively. Minerals concentration for Ca ranged from 1.79 (CLA) to 2.86 mg 100g‒1 (SON), Mg from 8.57 (SON) to 13.61 mg 100g‒1 (STA), K from 7.81 (SON) to 30.44 mg 100g‒1 (STA), Na from 12.21 (STA) to 15.59 mg 100g‒1 (CLA) and Fe from 0.82 (STA) to 1.89 mg 100g‒1 (SON). Stronger antioxidant activity was observed in SON paste for 1,1- diphenyl-2-picryl (DPPH) (62.07%), 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) (41%) and Ferric Reducing Antioxidant Power (FRAP) (47.88%). The results revealed that concentration of nutritive quality was specific to individual tomato paste, but SON possessed stronger antioxidant activity scavenging power than other tomato pastes. From the results of physicochemical and antioxidant activity of these tomato pastes, they may be used to boost physiological performance against degenerative diseases.
Pendidikan Islam pada Anak Usia Dini: Peran Orang Tua dalam Membentuk Identitas Keagamaan dalam Rumah Tangga
Authors: Hafid Abd. 
Published: September 2023

This study aimed to analyze the role of parents in shaping early childhood religious identity in the household. This research is qualitative research with a case study type. Samples in this study were taken using purposive sampling techniques in three families. Data was collected through interview, observation, and documentation techniques, and analyzed through four stages, namely data reduction, data display, verification, and conclusions. Data validity tests are carried out using the triangulation method. The results showed that in forming religious identity in early childhood, parents play more of a role as motivators by providing religious education from an early age. In addition, parents also provide concrete examples of practicing religious values in daily life in the household, and parents provide high support and motivation to children to get religious education both formally and non-formally.
Strategi Pengembangan Kompetensi Soft Skills Tenaga Kerja Di Balai Latihan Kerja (BLK)
Authors: Nuraeni Yeni 
Published: September 2023

Terjadinya perubahan di dunia industri menyebabkan perubahan juga di dunia kerja sehingga terjadi transformasi ketenagakerjaan. Industri saat ini tidak hanya membutuhkan kompetensi berkaitan dengan hard skill saja tetapi juga kompetensi di sisi soft skills. Lembaga pelatihan termasuk Balai Latihan Kerja (BLK) harus melakukan perubahan dan penyesuaian, termasuk untuk dapat mengantisipasi adanya perubahan kepesertaaan tenaga kerja dari generasi milineal ke generasi Z yang menimbulkan perubahan karakteristik tenaga kerja. Penelitian ini bertujuan untuk melakukan analisis terhadap kebutuhan softskill di era revolusi industri 4.0 & 5.0 dan bagaimana strategi BLK untuk dapat menghasilkan lulusannya yang memiliki kompetensi softskill sesuai dengan kebutuhan Dunia Usaha dan Dunia Industri. Metode penelitian ini yang digunakan adalah kualitatif desktriptif. Pengumpulan data primer dan sekunder dilakukan melalui serangkaian proses yang meliputi kajian literatur, Focus Group Discussion (FGD), wawancara mendalam dengan pemangku kepentingan terkait. Hasil penelitian menunjukan bahwa BLK harus melakukan perbaikan dan penguatan program pembelajaran di BLK yang berkaitan dengan berbagai aspek dengan melibatkan stakeholders terkait. Kesimpulan dari penelitian ini adalah perbaikan dan Pengembangan Sistem Pelatihan yang harus dilakukan oleh BLK yaitu ; Instruktur BLK 80-90% berasal dari Industri atau pelaku usaha yang berpengalaman, BLK memiliki sistem pengawasan untuk proses pembelajaran soft skills serta penambahan alokasi waktu pelatihan soft skills di BLK.
Efektivitas Sistem Pengendalian Internal Piutang Anggota Pada Koperasi Kredit Swasti Sari Kupang
Authors: Leu Theresia Fouk , Widyasari Yolanda O. M. 
Published: September 2023

The problem studied in this study is the weakness of the internal control system, such as there are still cooperative members who are late in paying their installments and there are also task traps. The formulation of the problem in this study is how the Level of Effectiveness of the Internal Control System of Member Receivables in the Swasti Sari Kupang Credit Cooperative. The purpose of this study is to determine the effectiveness of the internal control system of member receivables at the Swasti Sari Kupang Credit Cooperative. In accordance with the results of data analysis that has been stated in the previous chapter, it can be concluded that the internal control system of member receivables seen from 4 (four) research indicators, namely organizational structure, The authority system and recording procedures, healthy practices and competent employees at the Swasti Sari Kupang Credit Cooperative are classified as Effective, in accordance with the results of the calculation of the percentage of respondents' answers who answered Yes by 86.22%, which means that the Swasti Sari Kupang Cooperative has implemented elements of the implementation of the Member Receivables SPI, namely, the existence of an Organizational Structure, Authority System and Recording Procedures, Healthy Practices and Competent Employees.
The advice given based on the results of this study is: For the Swasti Sari Kupang Credit Cooperative, namely to maintain the Effectiveness of the Internal Control System that has been implemented so far. And it is also expected that institutions pay attention to the weaknesses of the internal control system such as: occurring task traps, there are members of the Cooperative who are late in paying their installments. For other research, this thesis can be used as a reference for other research in conducting similar research or further research on the Effectiveness of the Internal Control System for Member Receivables.
Peran Asuransi BPJS Ketenagakerjaan Terhadap Buruh Yang Bukan Penerima Upah (BPU) Di Kabupaten Batu Bara
Authors: Akbar Faisal , Arif Muhammad , Syahriza Rahmi 
Published: September 2023

BPJS Ketenagakerjaan (Badan Penyelenggara Jaminan Sosial) adalah program jaminan sosial yang merupakan tanggung jawab dan kewajiban Negara untuk memberikan perlindungan sosial ekonomi tertentu dan penyelenggaranya menggunakan mekanisme asuransi. Selain itu BPJS Ketenagakerjaan hanya di peruntukkan bagi tenaga kerja. Dalam program jaminan sosial ini ada 2 yaitu BPJS ketenagakerjaan dan BPJS Kesehatan, dan keduanya tentu memiliki fungsi yang berbeda. BPJS Ketenagakerjaan hanya diperuntukkan bagi tenaga kerja sedangkan BPJS Kesehatan diperuntukkan bagi seluruh lapisan masyarakat. BPJS Ketenagakerjaan memiliki empat jenis program jaminan sosial bagi tenaga kerja yaitu, Jaminan Kecelakaan Kerja (JKK), Jaminan Kematian (JK), Jaminan Hari Tua (JHT), dan Jaminan Pensiun (JP). Pada penelitian ini permasalahan yang muncul dari kurangnya kesadaran masayarakat yang berstatus Buruh yang Bukan Penelima Upah (BPU). Adapun poin yang harus di perhatikan oleh lembaga BPJS Ketenagakerjaan Kabupaten Batu Bara khususnya mengarah kepada buruh yang Bukan Penerima Upah (BPU) dikarenakan masih banyaknya masyarakat yang berstatus buruh belum mengetahui dan kurangnya pemahaman masyarakat terhadap BPJS Ketenagakerjaan, sangat banyaknya SDM di Kabupaten Batu Bara yang statusnya buruh harian lepas yang bekerja tidak menggunakan jaminan keselamatan kerja yaitu BPJS Ketenagakerjaan. Penelitian ini adalah penelitian Kualitatif Deskriftif dengan menggunakan data primer dalam bentuk wawancara kepada petugas bagian umum kantor BPJS Ketenagakerjaan dan narasumber dari para pekerja yang statusnya buruh yang Bukan Penerima Upah (BPU) dan data sekunder yaitu data yang di dapat dari refrensi berupa jurnal, tulisan, dan sumber lainnya. Berdasarkan hasil penelitian menunjukkan bahwa dalam peran BPJS Ketenagakerjaan pihak BPJS Ketenagakerjaan Kbupaten Batu Bara sudah melakukan persentase dalam bentuk sosialisasi ke desa-desa dengan peserta yang di hadiri oleh pekerja yang statusnya buruh harian lepas atau buruh yang Bukan Penerima Upah (BPU). Dan juga dari para buruh yang Bukan Penerima Upah (BPU) masih banyak yang belum mengetahui apa itu BPJS Ketenagakerjaan dan selama mereka bekerja mereka hanya mengetahui BPJS Kesehatan.
Pengaruh Kompetensi Profesional Guru,Motivasi Kerja Dan Semangatkerja Terhadap Kinerja Guru Di SMP Kadijah Padang
Authors: Sudirman Sudirman 
Published: September 2023

This study aims to determine the effect of teacher professional competence, work motivation and work enthusiasm both individually and collectively on teacher performance at SMP Kadijah Padang.
The subjects of this study were all 32 teachers at SMP Kadijah Padang. This research is an ex-post facto research. The data collection method uses a Likert scale model questionnaire for the variables of Teacher Professional Competence, Work Motivation and Work Spirit, while the Teacher Performance variable uses the questionnaire method, and documentation from the Principal. The data analysis technique used to test the hypothesis is the regression analysis technique.
The results of the study show that (1) there is a significant effect of teacher professional competence on teacher performance in SMP Kadijah Padang as evidenced by Fcount < Ftable (2.026 < 4.22), (2) there is a significant effect of work motivation on teacher performance - teachers at SMP Kadijah Padang as evidenced by: Fcount < Ftable (2.451 < 4.22), (3) there is a significant effect of morale on the performance of teachers at SMP Kadijah Padang as evidenced by: Fcount > Ftable (17.141 > 4, 22); the contribution of work enthusiasm to teacher performance is 39.73%; (4) there is a significant influence of the teacher's professional competence, work motivation and work enthusiasm together on the performance of teachers at SMP Kadijah Padang as evidenced by: Fcount > Ftable (5.832 > 3.01); the contribution of teacher professional competence, work motivation and work enthusiasm together to teacher performance is 42.16%.
Ampliación de distribución de Didelphis albiventris (Didelphimorphia, Didelphidae) en su extremo austral, provincia de Rio Negro, Argentina
Authors: Pastrán-López Orlando G. A. , Rivero-Castro Andrés G. , Ruiz-Estebez Elías G. , Amoni-Sacchi Hector J. , Sánchez-Castro Lilen 
Published: September 2023

Se presenta un nuevo registro de la comadreja overa (Didelphis albiventris) en el noreste
patagónico, puntualmente en el departamento de San Antonio, provincia de Río Negro, Argentina.
El registro se ubica en la ecorregión Monte de Llanuras y Mesetas y extiende la distribución conocida
para este marsupial a aproximadamente 152 km al sur de la referencia previa más cercana. Este
registro es además, el más austral documentado para la especie