bluuebunny/crossref_metadata_2025_split huggingface dataset:
4-Terminal Inorganic Perovskite/Organic Tandem Solar Cells Offer 22% Efficiency
Authors: Liu Ling , Xiao Hanrui , Jin Ke , Xiao Zuo , Du Xiaoyan , Yan Keyou , Hao Feng , Bao Qinye , Yi Chenyi , Liu Fangyang , Wang Wentao , Zuo Chuantian , Ding Liming 
Published: December 2022

AbstractAfter fast developing of single-junction perovskite solar cells and organic solar cells in the past 10 years, it is becoming harder and harder to improve their power conversion efficiencies. Tandem solar cells are receiving more and more attention because they have much higher theoretical efficiency than single-junction solar cells. Good device performance has been achieved for perovskite/silicon and perovskite/perovskite tandem solar cells, including 2-terminal and 4-terminal structures. However, very few studies have been done about 4-terminal inorganic perovskite/organic tandem solar cells. In this work, semi-transparent inorganic perovskite solar cells and organic solar cells are used to fabricate 4-terminal inorganic perovskite/organic tandem solar cells, achieving a power conversion efficiency of 21.25% for the tandem cells with spin-coated perovskite layer. By using drop-coating instead of spin-coating to make the inorganic perovskite films, 4-terminal tandem cells with an efficiency of 22.34% are made. The efficiency is higher than the reported 2-terminal and 4-terminal inorganic perovskite/organic tandem solar cells. In addition, equivalent 2-terminal tandem solar cells were fabricated by connecting the sub-cells in series. The stability of organic solar cells under continuous illumination is improved by using semi-transparent perovskite solar cells as filter.
Additive-Driven Interfacial Engineering of Aluminum Metal Anode for Ultralong Cycling Life
Authors: Kumar Sonal , Rama Prasad , Yang Gaoliang , Lieu Wei Ying , Chinnadurai Deviprasath , Seh Zhi Wei 
Published: December 2022

AbstractRechargeable Al batteries (RAB) are promising candidates for safe and environmentally sustainable battery systems with low-cost investments. However, the currently used aluminum chloride-based electrolytes present a significant challenge to commercialization due to their corrosive nature. Here, we report for the first time, a novel electrolyte combination for RAB based on aluminum trifluoromethanesulfonate (Al(OTf)3) with tetrabutylammonium chloride (TBAC) additive in diglyme. The presence of a mere 0.1 M of TBAC in the Al(OTf)3 electrolyte generates the charge carrying electrochemical species, which forms the basis of reaction at the electrodes. TBAC reduces the charge transfer resistance and the surface activation energy at the anode surface and also augments the dissociation of Al(OTf)3 to generate the solid electrolyte interphase components. Our electrolyte's superiority directly translates into reduced anodic overpotential for cells that ran for 1300 cycles in Al plating/stripping tests, the longest cycling life reported to date. This unique combination of salt and additive is non-corrosive, exhibits a high flash point and is cheaper than traditionally reported RAB electrolyte combinations, which makes it commercially promising. Through this report, we address a major roadblock in the commercialization of RAB and inspire equivalent electrolyte fabrication approaches for other metal anode batteries.
Phonembewusstheit von angehenden Grundschullehrkräften: Wie gut sind sie auf den schriftsprachlichen Anfangsunterricht vorbereitet?
Authors: Böhme Richard , Berendes Karin 
Published: December 2022

ZusammenfassungDie eigene Phonembewusstheit ist ein wichtiger Teil der diagnostischen Kompetenz von Grundschullehrkräften. International ist die Phonembewusstheit von Lehrkräften bereits umfassend untersucht, national besteht dazu noch ein Forschungsdesiderat. Deswegen wurde ein standardisiertes Testverfahren zur Erfassung der Phonembewusstheit entwickelt und bei N = 271 Grundschullehramtsstudierenden des höheren Fachsemesters in Baden-Württemberg und Bayern eingesetzt.Die explizite Phonembewusstheit der Studierenden ist mit 41 % korrekt gelöster Items eher gering. Hauptverantwortlich sind dafür orthografische Interferenzeffekte. Insgesamt überschätzen 73 % ihre Leistung, wobei der Effekt umso stärker auftritt, je geringer die Testleistung ist. Die praktischen Implikationen werden diskutiert.
Interfacial structure between TiN sintered ceramics with and without an Fe-containing grain boundary phase and Ag–Cu eutectic brazing filler material
Authors: Terasaki Nobuyuki , Kon Naochika , Chiba Hajime , Ohashi Touyou , Sekino Tohru 
Published: December 2022

AbstractTo focus on the interfacial reaction between the Ag–Cu alloy layer and TiN in active metal brazing, the Ag–Cu brazed interfacial structures between Cu and two types of TiN sintered ceramics fabricated by different methods were examined. No grain boundary phase components consisting of the Ni-containing Fe phase or Mo2C were detected on the TiN grain surfaces of the TiN liquid-phase sintered ceramic bonding surfaces before brazing. The brazed specimens were heated at 850 °C for 0.5 h. No Cu/TiN solid-phase sintered ceramic bonding was obtained. The Ag–Cu alloy layer was bonded onto the TiN grains in the TiN liquid-phase sintered ceramic through an Fe- and Ni-containing segregation layer. This segregation layer was formed by an interfacial reaction between the TiN grains and the Ni-containing Fe in the TiN liquid-phase sintered ceramic dissolved in the Ag–Cu liquid phase.
β-Hydroxybutyric acid improves cognitive function in a model of heat stress by promoting adult hippocampal neurogenesis
Authors: Huang Jian , Wu Yongji , Chai Xuejun , Wang Shuai , Zhao Yongkang , Hou Yan , Ma Yue , Chen Shulin , Zhao Shanting , Zhu Xiaoyan 
Published: December 2022

AbstractHeat stress has multiple potential effects on the brain, such as neuroinflammation, neurogenesis defects, and cognitive impairment. β-hydroxybutyric acid (BHBA) has been demonstrated to play neuroprotective roles in various models of neurological diseases. In the present study, we investigated the efficacy of BHBA in alleviating heat stress-induced impairments of adult hippocampal neurogenesis and cognitive function, as well as the underlying mechanisms. Mice were exposed to 43 ℃ for 15 min for 14 days after administration with saline, BHBA, or minocycline. Here, we showed for the first time that BHBA normalized memory ability in the heat stress-treated mice and attenuated heat stress-impaired hippocampal neurogenesis. Consistently, BHBA noticeably improved the synaptic plasticity in the heat stress-treated hippocampal neurons by inhibiting the decrease of synapse-associated proteins and the density of dendritic spines. Moreover, BHBA inhibited the expression of cleaved caspase-3 by suppressing endoplasmic reticulum (ER) stress, and increased the expression of brain-derived neurotrophic factor (BDNF) in the heat stress-treated hippocampus by activating the protein kinase B (Akt)/cAMP response element binding protein (CREB) and methyl-CpG binding protein 2 (MeCP2) pathways. These findings indicate that BHBA is a potential agent for improving cognitive functions in heat stress-treated mice. The action may be mediated by ER stress, and Akt-CREB-BDNF and MeCP2 pathways to improve adult hippocampal neurogenesis and synaptic plasticity.
The Jasmine (Jasminum Sambac) Genome Provides Insight into the Biosynthesis of Flower Fragrances and Jasmonates
Authors: Chen Gang , Mostafa Salma , Lu Zhaogeng , Du Ran , Cui Jiawen , Wang Yun , Liao Qinggang , Lu Jinkai , Mao Xinyu , Chang Bang , Gan Quan , Wang Li , Jia Zhichao , Yang Xiulian , Zhu Yingfang , Yan Jianbin , Jin Biao 
Published: December 2022

Abstract
Jasminum sambac (jasmine flower), a world-renowned plant appreciated for its exceptional flower fragrance, is of cultural and economic importance. However, the genetic basis of its fragrance is largely unknown. Here, we present the first de novo genome assembly of J. sambac with 550.12 Mb (scaffold N50 = 40.10 Mb) assembled into 13 pseudochromosomes. Terpene synthase (TPS) genes associated with flower fragrance are considerably amplified in the form of gene clusters through tandem duplications in the genome. Gene clusters within the salicylic acid/benzoic acid/theobromine (SABATH) and benzylalcohol O-acetyltransferase/anthocyanin O-hydroxycinnamoyltransferases/anthranilate N-hydroxycinnamoyl/benzoyltransferase/deacetylvindoline 4-O-acetyltransferase (BAHD) superfamilies were identified to be related to the biosynthesis of phenylpropanoid/benzenoid compounds. Several key genes involved in jasmonate biosynthesis were duplicated, causing an increase in copy numbers. In addition, multi-omics analyses identified various aromatic compounds and many genes involved in fragrance biosynthesis pathways. Furthermore, the roles of JsTPS3 in β-ocimene biosynthesis, as well as JsAOC1 and JsAOS in jasmonic acid biosynthesis, were functionally validated. The genome assembled in this study for J. sambac offers a basic genetic resource for studying floral scent and jasmonate biosynthesis, and provides a foundation for functional genomic research and variety improvements in Jasminum.
Themes for future research on memory, mind and media
Authors: Wertsch James V. , Roediger Henry L. 
Published: December 2022

Abstract
We describe three areas of inquiry that we foresee as being important in future studies of collective memory, mind, and media. The first is the power of narratives, usually provided by collectives, which can be explicit and conscious or implicit and unconscious. A second important theme during this period of populism and nationalism is the study of the self-centredness (or egocentricity) of groups, especially nations believing their past is special. Such egocentricity can feed conflict among nations as well as groups within nations. The third important direction for research is future thinking, or studies of how people anticipate events they expect to unroll in their future and whether these events are mostly positive or negative. A puzzle of future thinking relative to collective memory is why people readily argue about and even fight over events from the past, but find it much more difficult to mobilise groups about life-threatening future events such as global warming or nuclear war. We look forward to studies in these crucial topics and others as they appear in Memory, Mind & Media.
Design of miniaturized single and dual-band bandpass filters using diamond-shaped coupled line resonator for next-generation wireless systems
Authors: Mushtaq Bilal , Khalid Sohail 
Published: December 2022

AbstractThis paper presents a multi-mode resonator (MMR) for next-generation wireless systems that achieves single and dual-band bandpass filter (BPF) responses using a split-ring dual-path structure. The proposed BPF design is realized by employing two pairs of parallel couple lines and two symmetrical step-impedance open-circuited stubs (SIOCS). SIOCS are used to improve selectivity and increase the number of transmission zeros/poles. The proposed single-band BPF exhibits an ultra-wideband (UWB) response having a center frequency of 7.5 GHz, a minimum insertion loss of less than 0.48 dB, and a maximum return loss of 25.35 dB. The proposed UWB BPF has a stopband suppression of 39.34 dB up to 18 GHz and a 3 dB fractional bandwidth of 48.23%. Moreover, a dual-band BPF has been accomplished by utilizing the same architecture while slightly changing the MMR structure and adding more coupling. The center frequency (bandwidth) of the dual broadband BPF is 7.40 GHz (2.40 GHz) and 14.15 GHz (1.7 GHz), respectively. The measured minimum insertion loss is less than 0.23 dB and a return loss of less than 16.8 dB with 3 dB FBWs of 32.4 and 12.1%. Finally, two prototypes are fabricated to validate the proposed characteristics. The BPF's simulated and measured results are in good agreement.
High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells
Authors: Hennig Paulina , Di Filippo Michela , Bilfeld Gilles , Mellett Mark , Beer Hans-Dietmar 
Published: December 2022

AbstractNLRP1 is the primary inflammasome sensor in human keratinocytes. Sensing of UVB radiation by NLRP1 is believed to underlie the induction of sunburn. Although constitutive NLRP1 activation causes skin inflammation and predisposes patients to the development of cutaneous SCCs, the NLRP1 pathway is suppressed in established SCCs. Here, we identified high levels of the autophagy receptor p62 in SCC cells lines and SCC tumors. Increased NF-κB activity in SCC cells causes p62 up-regulation. Suppression of p62 expression rescues UVB-induced NLRP1 inflammasome activation in early-stage SCC cells. p62 expression protects SCC cells from cytotoxic drugs, whereas NLRP1 sensitizes them. In summary, we identify p62 as a novel negative regulator of the NLRP1 inflammasome in human cutaneous SCC cells, in which suppression of NLRP1 by increased levels of p62 supports stress resistance of skin cancer cells.
Recent progress in ferroptosis: inducers and inhibitors
Authors: Du Yunxi , Guo Zhong 
Published: December 2022

AbstractFerroptosis is a new iron-dependent form of programmed cell death characterized by iron accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous interest in disease treatment research communities in pursuit to reveal the mechanism and key targets of ferroptosis because ferroptosis is closely related to the pathophysiological processes of many diseases. Recent studies have shown some key targets, such as glutathione peroxidase 4 (GPX4) and System Xc−, and several inducers and inhibitors have been developed to regulate these key targets. With the emergence of new ferroptosis targets, studies on inducers and inhibitors have made new developments. The selection and use of inducers and inhibitors are very important for related work. This paper briefly introduces important regulatory targets in the ferroptosis metabolic pathway, lists and categorizes commonly used and recently developed inducers and inhibitors, and discusses their medical application. The paper ends of with potential future research direction for ferroptosis.
Efficient neural codes naturally emerge through gradient descent learning
Authors: Benjamin Ari S. , Zhang Ling-Qi , Qiu Cheng , Stocker Alan A. , Kording Konrad P. 
Published: December 2022

AbstractHuman sensory systems are more sensitive to common features in the environment than uncommon features. For example, small deviations from the more frequently encountered horizontal orientations can be more easily detected than small deviations from the less frequent diagonal ones. Here we find that artificial neural networks trained to recognize objects also have patterns of sensitivity that match the statistics of features in images. To interpret these findings, we show mathematically that learning with gradient descent in neural networks preferentially creates representations that are more sensitive to common features, a hallmark of efficient coding. This effect occurs in systems with otherwise unconstrained coding resources, and additionally when learning towards both supervised and unsupervised objectives. This result demonstrates that efficient codes can naturally emerge from gradient-like learning.
Plant-specific features of respiratory supercomplex I + III2 from Vigna radiata
Authors: Maldonado M. , Fan Z. , Abe K. M. , Letts J. A. 
Published: December 2022

AbstractThe last steps of cellular respiration—an essential metabolic process in plants—are carried out by mitochondrial oxidative phosphorylation. This process involves a chain of multi-subunit membrane protein complexes (complexes I–V) that form higher-order assemblies called supercomplexes. Although supercomplexes are the most physiologically relevant form of the oxidative phosphorylation complexes, their functions and structures remain mostly unknown. Here we present the cryogenic electron microscopy structure of the supercomplex I + III2 from Vigna radiata (mung bean). The structure contains the full subunit complement of complex I, including a newly assigned, plant-specific subunit. It also shows differences in the mitochondrial processing peptidase domain of complex III2 relative to a previously determined supercomplex with complex IV. The supercomplex interface, while reminiscent of that in other organisms, is plant specific, with a major interface involving complex III2’s mitochondrial processing peptidase domain and no participation of complex I’s bridge domain. The complex I structure suggests that the bridge domain sets the angle between the enzyme’s two arms, limiting large-scale conformational changes. Moreover, complex I’s catalytic loops and its response in active-to-deactive assays suggest that, in V. radiata, the resting complex adopts a non-canonical state and can sample deactive- or open-like conformations even in the presence of substrate. This study widens our understanding of the possible conformations and behaviour of complex I and supercomplex I + III2. Further studies of complex I and its supercomplexes in diverse organisms are needed to determine the universal and clade-specific mechanisms of respiration.
A transcriptome dataset for gonadectomy-induced changes in rat spinal cord
Authors: Miller Shawn , Abrahante Juan E. , Roopra Avtar , Dougherty Brendan J. 
Published: December 2022

AbstractCirculating sex steroid hormones are critical for neural function and development of neuroplasticity in many regions of the central nervous system. In the spinal cord, our knowledge of steroid hormone influence mostly derives from mechanistic studies of pain processing in dorsal spinal cord circuits; less is known regarding hormonal influence of ventral spinal motor function. Gonadectomy (surgical removal of the testes in males and ovaries in females) rapidly and persistently reduces circulating sex steroids in both females and males, providing a means to interrogate the role of hormones on neural function. Here we provide a next-generation RNA sequencing (RNA-seq) data set to evaluate the impact of gonadectomy on the transcriptome of ventral spinal cord tissue of adult female and male rats.
The surgical resection of the primary tumor increases survival in patients with EGFR-mutant advanced non-small cell lung cancer: a tertiary center cohort study
Authors: Chen Ying-Yuan , Su Po-Lan , Huang Wei-Li , Chang Chao-Chun , Yen Yi-Ting , Lin Chien-Chung , Tseng Yau-Lin 
Published: December 2022

AbstractTumor resection could increase treatment efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) in patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC). This study aimed to retrospectively analyze patients with advanced EGFR-mutant NSCLC from a Taiwanese tertiary center and receiving EGFR-TKI treatment with or without tumor resection. A total of 349 patients were enrolled. After propensity score matching, 53 EGFR-TKI treated patients and 53 EGFR-TKI treated patients with tumor resection were analyzed. The tumor resection group showed improved progression-free survival (PFS) (52.0 vs. 9.8 months; hazard ratio [HR] = 0.19; p < 0.001) and overall survival (OS) (not reached vs. 30.6 months; HR = 0.14; p < 0.001) compared to the monotherapy group. In the subgroup analysis of patients with newly-diagnosed NSCLC, the tumor resection group showed longer PFS (52.0 vs. 9.9 months; HR = 0.14; p < 0.001) and OS (not reached vs. 32.6 months; HR = 0.12; p < 0.001) than the monotherapy group. In conclusion. the combination of EGFR-TKI and tumor resection provided better PFS and OS than EGFR-TKI alone, and patients who underwent tumor resection within six months had fewer co-existing genomic alterations and better PFS.
Early visual deprivation disrupts the mental representation of numbers in visually impaired children
Authors: Cappagli G. , Cuturi L. F. , Signorini S. , Morelli F. , Cocchi E. , Gori M. 
Published: December 2022

AbstractSeveral shreds of evidence indicate that visual deprivation does not alter numerical competence neither in adults nor in children. However, studies reporting non-impaired numerical abilities in the visually impaired population present some limitations: (a) they mainly assessed the ability to process numbers (e.g. mathematical competence) rather than represent numbers (e.g. mental number line); (b) they principally focused on positive rather than negative number estimates; (c) they investigated numerical abilities in adult individuals except one focusing on children (Crollen et al. in Cognition 210:104586, 2021). Overall, this could limit a comprehensive explanation of the role exerted by vision on numerical processing when vision is compromised. Here we investigated how congenital visual deprivation affects the ability to represent positive and negative numbers in horizontal and sagittal planes in visually impaired children (thirteen children with low vision, eight children with complete blindness, age range 6–15 years old). We adapted the number-to-position paradigm adopted by Crollen et al. (Cognition 210:104586, 2021), asking children to indicate the spatial position of positive and negative numbers on a graduated rule positioned horizontally or sagittally in the frontal plane. Results suggest that long-term visual deprivation alters the ability to identify the spatial position of numbers independently of the spatial plane and the number polarity. Moreover, results indicate that relying on poor visual acuity is detrimental for low vision children when asked to localize both positive and negative numbers in space, suggesting that visual experience might have a differential role in numerical processing depending on number polarity. Such findings add knowledge related to the impact of visual experience on numerical processing. Since both positive and negative numbers are fundamental aspects of learning mathematical principles, the outcomes of the present study inform about the need to implement early rehabilitation strategies to prevent the risk of numerical difficulties in visually impaired children.
Precise measurement of gene expression changes in mouse brain areas denervated by injury
Authors: Schlaudraff Jessica , Paul Mandy H. , Deller Thomas , Del Turco Domenico 
Published: December 2022

AbstractQuantitative PCR (qPCR) is a widely used method to study gene expression changes following brain injury. The accuracy of this method depends on the tissue harvested, the time course analyzed and, in particular on the choice of appropriate internal controls, i.e., reference genes (RGs). In the present study we have developed and validated an algorithm for the accurate normalization of qPCR data using laser microdissected tissue from the mouse dentate gyrus after entorhinal denervation at 0, 1, 3, 7, 14 and 28 days postlesion. The expression stabilities of ten candidate RGs were evaluated in the denervated granule cell layer (gcl) and outer molecular layer (oml) of the dentate gyrus. Advanced software algorithms demonstrated differences in stability for single RGs in the two layers at several time points postlesion. In comparison, a normalization index of several stable RGs covered the entire post-lesional time course and showed high stability. Using these RGs, we validated our findings and quantified glial fibrillary acidic protein (Gfap) mRNA and allograft inflammatory factor 1 (Aif1/Iba1) mRNA in the denervated oml. We compared the use of single RGs for normalization with the normalization index and found that single RGs yield variable results. In contrast, the normalization index gave stable results. In sum, our study shows that qPCR can yield precise, reliable, and reproducible datasets even under such complex conditions as brain injury or denervation, provided appropriate RGs for the model are used. The algorithm reported here can easily be adapted and transferred to any other brain injury model.