bluuebunny/crossref_metadata_2025_split huggingface dataset:
An interpretable machine-learning model for predicting the efficacy of nonsteroidal anti-inflammatory drugs for closing hemodynamically significant patent ductus arteriosus in preterm infants
Authors: Liu Tai-Xiang , Zheng Jin-Xin , Chen Zheng , Zhang Zi-Chen , Li Dan , Shi Li-Ping 
Published: April 2023

BackgroundNonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used in the closure of ductus arteriosus in premature infants. We aimed to develop and validate an interpretable machine-learning model for predicting the efficacy of NSAIDs for closing hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants.MethodsWe assessed 182 preterm infants ≤ 30 weeks of gestational age first treated with NSAIDs to close hsPDA. According to the treatment outcome, patients were divided into a “success” group and “failure” group. Variables for analysis were demographic features, clinical features, as well as laboratory and echocardiographic parameters within 72 h before medication use. We developed the machine-learning model using random forests. Model performance was assessed by the area under the receiver operating characteristic curve (AUC). Variable-importance and marginal-effect plots were constructed to explain the predictive model. The model was validated using an external cohort of two preterm infants who received ibuprofen (p.o.) to treat hsPDA.ResultsEighty-three cases (45.6%) were in the success group and 99 (54.4%) in the failure group. Infants in the success group were associated with maternal chorioamnionitis (p = 0.002), multiple births (p = 0.007), gestational age at birth (p = 0.020), use of indometacin (p = 0.007), use of inotropic agents (p &lt; 0.001), noninvasive ventilation (p = 0.001), plasma albumin level (p &lt; 0.001), PDA size (p = 0.038) and Vmax (p = 0.013). Multivariable binary logistic regression analysis showed that maternal chorioamnionitis, multiple births, use of indomethacin, use of inotropic agents, plasma albumin level, and PDA size were independent risk factors influencing the efficacy of NSAIDs (p &lt; 0.05). The AUC of the random forest model was 0.792. The top-three features contributing most to the model in the variable-importance plot were the plasma albumin level and platelet count 72 h before treatment and 24-h urine volume before treatment. In the external cohort, treatment succeeded in one case and failed in the other. The probabilities of success and failure predicted by the random forest model were 60.2% and 48.4%, respectively.ConclusionBased on clinical, laboratory, and echocardiographic features before first-time NSAIDs treatment, we constructed an interpretable machine-learning model, which has a certain reference value for predicting the closure of hsPDA in premature infants under 30 weeks of gestational age.
Formalism of the NanOx biophysical model for radiotherapy applications
Authors: Alcocer-Ávila Mario , Monini Caterina , Cunha Micaela , Testa Étienne , Beuve Michaël 
Published: April 2023

Introduction: NanOx is a theoretical framework developed to predict cell survival to ionizing radiation in the context of radiotherapy. Based on statistical physics, NanOx takes the stochastic nature of radiation at different spatial scales fully into account. It extends concepts from microdosimetry to nanodosimetry, and considers as well the primary oxidative stress. This article presents in detail the general formalism behind NanOx.Methods: Cell death induction in NanOx is modeled through two types of biological events: the local lethal events, modeled by the inactivation of nanometric sensitive targets, and the global events, represented by the toxic accumulation of oxidative stress and sublethal lesions. The model is structured into general premises and postulates, the theoretical bases compliant with radiation physics and chemistry, and into simplifications and approximations, which are required for its practical implementation.Results: Calculations performed with NanOx showed that the energy deposited in the penumbra of ion tracks may be neglected for the low-energy ions encountered in some radiotherapy techniques, such as targeted radionuclide therapy. On the other hand, the hydroxyl radical concentration induced by ions was shown to be larger for low-LET ions and to decrease faster with time compared to photons. Starting from the general formalism of the NanOx model, an expression was derived for the cell survival to local lethal events in the track-segment approximation.Discussion: The NanOx model combines premises of existing biophysical models with fully innovative features to consider the stochastic effects of radiation at all levels in order to estimate cell survival and the relative biological effectiveness of ions. The details about the NanOx model formalism given in this paper allow anyone to implement the model and modify it by introducing different approximations and simplifications to improve it, or even adapt it to other medical applications.
Fathers’ presence and adolescents’ interpersonal relationship quality: Moderated mediation model
Authors: Li Ao , Sun Li , Fan ShiQing 
Published: April 2023

IntroductionMost previous studies focused on the effects of fathers’ presence on adolescent development, but rarely examined the mechanisms underlying the presence of fathers on adolescent development. Moreover, previous studies ignored the impact of fathers’ way of being present on adolescent interpersonal relationships. Based on social identity theory, the present study introduced adolescents’ social responsibility as a mediating variable to explore the influence of father’s presence style on adolescents’ interpersonal. This study examined the mechanism of fathers’ way of being present on father’s presence, adolescents’ social responsibility, and their quality of interpersonal relationships; if fathers adopt a democratic approach to be present, the study examines whether teenagers are more likely to enhance their sense of social responsibility and achieve harmonious interpersonal relationships.MethodsParticipants were 1,942 senior high school and college students who responded to the Fatherhood Questionnaire, Social Responsibility Questionnaire, and Interpersonal Relationship Quality Diagnosis Scale. This study used PROCESS macro of SPSS 24.0 and Amos 26.0 to examine the hypotheses.ResultsEmpirical results demonstrated that (a) fathers’ presence is directly and positively related to adolescents’ social responsibility, (b) fathers’ presence is indirectly and positively related to the quality of adolescents’ interpersonal relationships through social responsibility, and (c) parenting styles played a moderating role in the first half of the fathers’ presence on social responsibility and the quality of interpersonal relationships. Results demonstrated that more harmonious interpersonal relationships were present among teenagers when fathers adopted a democratic upbringing, and this interaction effect on interpersonal relationships was mediated by teenagers’ sense of social responsibility.DiscussionThe findings of this study enrich the literature by exploring the significance of emphasizing fathers’ democratic presence on teenagers’ sense of social responsibility and interpersonal relationships. The practical implications of this study are that society should encourage more fathers to be present and guide them to adopt a democratic parenting style that will benefit adolescents’ development and family well-being.
Characterizing spatial burn severity patterns of 2016 Chimney Tops 2 fire using multi-temporal Landsat and NEON LiDAR data
Authors: Park Taejin , Sim Sunhui 
Published: April 2023

The Chimney Tops 2 wildfire (CT2) in 2016 at Great Smoky Mountains National Park (GSMNP) was recorded as the largest fire in GSMNP history. Understanding spatial patterns of burn severity and its underlying controlling factors is essential for managing the forests affected and reducing future fire risks; however, this has not been well understood. Here, we formulated two research questions: 1) What were the most important factors characterizing the patterns of burn severity in the CT2 fire? 2) Were burn severity measures from passive and active optical remote sensing sensors providing consistent views of fire damage? To address these questions, we used multitemporal Landsat- and lidar-based burn severity measures, i.e., relativized differenced Normalized Burn Ratio (RdNBR) and relativized differenced Mean Tree Height (RdMTH). A random forest approach was used to identify key drivers in characterizing spatial variability of burn severity, and the partial dependence of each explanatory variable was further evaluated. We found that pre-fire vegetation structure and topography both play significant roles in characterizing heterogeneous mixed burn severity patterns in the CT2 fire. Mean tree height, elevation, and topographic position emerged as key factors in explaining burn severity variation. We observed generally consistent spatial patterns from Landsat- and lidar-based burn severity measures. However, vegetation type and structure-dependent relations between RdNBR and RdMTH caused locally inconsistent burn severity patterns, particularly in high RdNBR regions. Our study highlights the important roles of pre-fire vegetation structure and topography in understanding burn severity patterns and urges to integrate both spectral and structural changes to fully map and understand fire impacts on forest ecosystems.
Predicting prognosis and clinical efficacy of immune checkpoint blockade therapy via interferon-alpha response in muscle-invasive bladder cancer
Authors: Fan Bohan , Zheng Xin , Wang Yicun , Hu Xiaopeng 
Published: April 2023

Background: Immune checkpoint blockade (ICB) can prompt durable and robust responses in multiple cancers, involving muscle-invasive bladder cancer (MIBC). However, only a limited fraction of patients received clinical benefit. Clarifying the determinants of response and exploring corresponding predictive biomarkers is key to improving outcomes.Methods: Four independent formerly published cohorts consisting of 641 MIBC patients were enrolled in this study. We first analyzed the associations between various cancer hallmarks and ICB therapy response in two immunotherapeutic cohorts to identify the leading prognostic hallmark in MIBC. Furthermore, advanced machine learning methods were performed to select robust and promising predictors from genes functioning in the above leading pathway. The predictive ability of selected genes was also validated in multiple MIBC cohorts.Results: We identified and verified IFNα response as the leading cancer hallmark indicating better treatment responses, favorable overall survival, and an inflamed tumor microenvironment with higher infiltration of immune effector cells in MIBC patients treated with ICB therapy. Subsequently, two commonly selected genes, CXCL10 and LAMP3, implied better therapy response and the CXCL10highLAMP3high patients would benefit more from ICB therapy, which was comprehensively validated from the perspective of gene expression, clinical response, patient survival and immune features.Conclusion: Higher IFNα response primarily predicted better ICB therapeutic responses and reflected an inflamed microenvironment in MIBC. A composite of CXCL10 and LAMP3 expression could serve as promising predictive biomarkers for ICB therapeutic responses and be beneficial for clinical decision-making in MIBC.
Le maternel et le féminin : deux espaces de la vie psychique
Authors: Guignard Florence 
Published: April 2023

Florence Guignard, The maternal and the féminin components : two spaces of psychic life.
The author proposes two metaphorical models: the primary maternal, which contains the primary drive conflict, and the primary feminine, containing the constitution of desire. These two models represent an aspect of psychic space and designate two areas that both constitute and are constituted by the first intrapsychic conflicts. Starting with Freud, the author then examines the contributions of other authors (Bion, Fain, Meltzer, Rank, etc.) that support her concept of an intimate relationship based on identifications as well as object relations.

Key-words : Primary drive conflict, Constitution of desire, Masochism-feminity = Moebius strip.
Du corps à la pensée : empreintes du maternel
Authors: Emmanuelli Michèle , Boekholt Monika 
Published: April 2023

Cet article présente les résultats d'une recherche sur le fonctionnement psychique féminin, à partir d'un entretien et de deux épreuves projectives, le Rorschach et le TAT.
Le thème de la recherche et le sexe des psychologues cliniciennes ont, semble-t-il, infléchi la relation transférentielle dans un registre maternel. C'est de ce point de vue
que l'on peut comprendre les résultats, portant sur les différents registres de figuration du corps, les identifications et les représentations de relations. L'impact différentiel du Rorschach et du TAT y apparaît clairement.
La population est constituée de trente jeunes femmes âgées de 18 à 35 ans, non consultantes en psychiatrie.

Mots-clés : Féminin, Maternel, Rorschach, TAT, Transfert/épreuves projectives.
Fantasme d'infanticide et construction du narcissisme primaire ; expression projective au Rorschach et au TAT
Authors: Roman Pascal 
Published: April 2023

L'hypothèse que je me propose de mettre ici au travail est que les processus en jeu dans la constitution du narcissisme primaire mobilisent électivement les enjeux liés au fantasme d'infanticide et à la perlaboration d'une violence primitive. Dans ce cadre, une lecture de protocoles d'épreuves projectives (Rorschach et T.A.T) recueillis auprès d'enfants confrontés à l'expérience d'une violence parentale non élaborée, permet de repérer les éléments propres à spécifier des avatars dans les émergences symbolisantes.
Les caractéristiques propres à ces protocoles (expression brute de fantasmes violents, marques d'une répétition de type traumatique, instabilité des investissements identitaires et identificatoires...) ouvrent sur des perspectives pour penser un lien inter-fantasmatique au sein du groupe familial à partir du concept de violence fondamentale décrit par J. Bergeret.

Mots-clés : Fantasme d'infanticide. Narcissisme primaire, Violence fondamentale, Épreuves projectives.
Le « pervers » : agresseur ou victime ? Étude du Rorschach
Authors: Duflot Colette 
Published: April 2023

Colette Duflot, The "Pervert" : aggressor or victim ? Rorschach Study.
In the context of judicial assessments, psychologists encounter aggressors who are shown through clinical examination to have been victims themselves of diverse types of violence during their childhood.
One case study involving anamnesis, Rorschach and an interview immediately after the very revealing set of Rorschach responses illustrates this finding by bringing to light the weakness of the family's symbolic structure and the traumas which preceeded the burgeoning of sexual violence in a subject whose split functioning permitted superficial socio-affective adaptation to coexist with a fantasy world of the sado-masochistic type which was impossible to integrate.

Key-words : Sexual aggression, Rorschach, splitting
Actualité de la névrose
Authors: Chabert Catherine 
Published: April 2023

Catherine Chabert, Actualidad de la neurosis.
El desarrollo de las modalidades de funcionamiento de los estados-límites, permitiendo al mismo tiempo afinar el diagnóstico diferencial de las neurosis, ha entranado progresivamente un desvío en la aproximación de estas organizaciones psicopatológicas. La tendencia de hoy en día va en el sentido de la multiplicación de diagnósticos de funcionamientos Iímites y narcisistas.
Se trata de un cambio de la clínica ? Se trata de una contaminación que haria perder de vista las características efectivas de la neurosis ?
A partir de estos cuestionamientos, nos proponemos establecer rigurosamente, a través de la clínica proyectiva (Rorschach y TAT), los criterios diferenciadores que darán cuenta de la naturaleza intra-psáquica de los conflictos, de la especificidad de los mecanismos de defensa y de la articulación de las problemáticas neuróticas, poniendo especialmente en evidencia el interés del núcleo histérico que condiciona el funcionamiento.

Palabras-clave : Neurosis, Funcionamiento límite, Rorschach, TAT, Diagnóstico diferencial.
Approche analytique et système intégré : tous les chemins mènent-ils à Rome ?
Authors: Husain Odile 
Published: April 2023

Odile Husain, The Psychoanalytical Approach and the Comprehensive System : Do All Roads Lead to Rome ?
Confronting the psychoanalytical approach of the Rorschach and the Comprehensive System immediately raises a question of definition. Whereas the Comprehensive System generates a unified representation among its users, the same cannot be said for practitioners who claim their affiliation to the analytical approach. We will first examine compatibility as a trend and will wonder about the need for differentiating an addition of models from an integration of models. At a time when the tendency is one of reconciliation, we shall agree to disagree and will look upon these two models as both divergent and incompatible. Lastly, we will examine certain points of convergence which do not necessarily contradict the viewpoint of incompatibility.

Keywords : Rorschach - Analytical approach - Comprehensive System - Integration
Troubles du comportement chez l'enfant et dépendance à l'environnement : complémentarité des épreuves projectives
Authors: Cohen de Lara Aline 
Published: April 2023

Aline Cohen de Lara, Trastomos del comportamiento en el niño y dependencia al entorno. Complementaridad de las pruebas proyectivas.
A pesar de la similitud de los síntomas y de la pertenencia común al registro de los funcionamientos limites, los niños que presentan trastomos de la conducta y del comportamiento, relevan de organizaciones psicopatológicas diversas. Esto incita a ofrecer tratamientos diferenciados, individualizados, que pueden proponerse en un cuadro común de tomar a cargo. La noción de cuadro es fundamental en esta población por la cual la investigación ha mostrado la extrema sensibilidad a las modificaciones del entomo, de allí la necesidad de tener en cuenta en el tratamiento las interacciones con el medio. La aplicación de las pruebas proyeetivas de Rorschach y de TAT, consideradas como dos tipos de entornos, ha permitido constatar los modos de reac ción diferenciados en función del material y de los niños. Según la prueba propuesta, se deja al sujeto situarse a un grado de libertad variable. Paradoxalmente, el material no estructurado del Rorschach favorisó una mayor flexibilidad asociativa que las figuraciones impuestas del TAT, que tienen un efecto intrusivo y a veces desorganizante, bloqueando las capacidades de funcionamiento en un área transicional restricta. La distancia más o menos importante de tratamiento entre las dos puebas señala el impacto diferenciado del entorno sobre el funcionamiento psíquico. Esto constituye un indice de evaluación de la dependencia a los objetos externos, evaluación particularmente importante en relación a esa población a riesgos evolutivos múltiples, la dimension pronóstica estando íntimamente ligada, entre otras cosas, a los encuentros próximos y a la realidad del entomo en el cual los niños van a evolucionar.

Palabras-clave : Niños agitados - Trastomos del comportamiento - Patologías del actuar - Representación psíquica - Dependencia - Rorschach - TAT.
Conferencia Iberoamericana de Ministros de Cultura. Declaración de Panamá
Authors: - - 
Published: April 2023

Los Ministros y Responsables de Políticas Culturales de Iberoamérica nos hemos reunido en Panamá los días 5 y 6 de septiembre de 2000, con el fin de analizar las políticas culturales con y para la infancia y la juventud.
Los resultados de nuestras deliberaciones, que elevamos a la próxima Cumbre Iberoamericana de Jefes de Estado y de Gobierno a celebrarse en Panamá en noviembre de 2000, son los siguientes:
Uno de los más importantes elementos constitutivos de la Comunidad Iberoamericana está dado por su dimensión cultural, basada en el conjunto de valores y en el patrimonio común. La infancia y la juventud iberoamericanas son parte activa y fundamental en la construcción y transmisión de esta vitalidad diversa y multicultural.
Presentación. Profesión docente
Authors: Martínez Santiago Roberto 
Published: April 2023

Nuestra intención, manifestada en el planteamiento previo que hicimos a los autores invitados, era la de revisar la evolución de la profesión docente en relación con las reformas que desde hace más de diez años se vienen dando en los sistemas educativos iberoamericanos, y de las transformaciones habidas en las sociedades en las que intervienen.
Tanto el Comité Científico como la Dirección de la Revista entendieron que, si los mensajes repetidos desde todas las administraciones educativas reconocen a los docentes como actores principales del proceso de enseñanza–aprendizaje y de las reformas que lo afectan, debieron asignarles algún papel significativo en la puesta en práctica de estas últimas.
Ese papel pudo cambiar, y seguramente lo hizo, algunas o muchas de las condiciones profesionales y laborales en las que los docentes desempeñan su trabajo. También pudo afectar a la imagen que poseían de sí mismos o a las expectativas y el reconocimiento que otros actores tenían respecto de ellos.
[Reseña] Pedagogía de la muerte a través del cine
Authors: Asensi Díaz Jesús 
Published: April 2023

Mar Cortina Selva y Agustín de la Herrán. Pedagogía de la muerte a través del cine. Madrid: Universitas. 2011. 256 págs. isbn: 978-84-7991-350-2.
Después de la impactante obra «La muerte y su didáctica. Manual para Educación Infantil, Primaria y Secundaria» (2006), sus autores, los profesores Agustín de la Herrán y Mar Cortina vuelven a insistir en este tema tan relacionado con la formación humana como relegado o tapado por la sociedad. Y lo hacen ahora con un libro, «Pedagogía de la muerte a través del cine», que ellos coordinan y en el que colaboran otros autores. La idea fundamental es que la muerte es uno de los acontecimientos más radicales de la vida humana que la educación no debiera eludir, como lo hace. Ocultarla, banalizarla no conduce a nada. Tratarla o normalizarla en la educación conduciría a «una formación más equilibrada, mejor orientada y más humana de la persona y, desde ella, de los colectivos sociales», aseguran sus autores...
[Reseña] La dirección de centros educativos en Iberoamérica. Reflexiones y experiencias
Authors: Silva Patricia 
Published: April 2023

Joaquín Gairín (coord.). La dirección de centros educativos en Iberoamérica. Reflexiones y experiencias. Santiago de Chile: Fidecap. 265 págs. 2011. ISBN: 978-956-8986-01-8.
El libro es una herramienta de gran utilidad para los interesados en la Dirección Escolar. Las consideraciones y recomendaciones que se presentan son el resultado del análisis valorativo de más de veinticinco especialistas de doce países iberoamericanos que pertenecen a la Red AGE (Red de apoyo a la gestión educativa)...