bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Beneficial Effects of Ivabradine Aganist Myocardial Damage induced by Isoproterenol in Rats
Authors: Polat Seyhan , Altuntas Miray , Gunata Mehmet , Polat Alaadin , Tanriverdi Lokman Hekim , Yildiz Azibe , Durhan Merve , Vardi Nigar , Cigremis Yilmaz , Parlakpinar Hakan 
Published: February 2023

Abstract
Purpose: We aimed to investigate the potential benefits of two doses of ivabradine against isoproterenol-induced myocardial damage in rats.
Methods: The rats were randomly divided into 4 groups: Control (n=8); Saline was administered, Isoproterenol (ISO) (n=12); 150 mg/kg ISO was administered for 2 days, ISO+Low-dose IVA (ISO+LIVA) (n=12); 1 mg/kg IVA was administered for 4 days in addition to ISO. ISO+High-dose IVA (ISO+HIVA) group (n=12): 10 mg/kg IVA was administered for 4 days in addition to ISO. Thereafter, hemodynamic, histopathological, and biochemical studies were performed.
Results: In the ISO+LIVA and ISO+HIVA groups, ISO-induced myocardial changes including increase in density of granulation tissue and degenerated cardiomyocyte were equally decreased. HR was mildly reduced and arterial blood pressures were slightly increased in the IVA-treated groups versus the ISO group. In the hearts of IVA-treated groups, malondialdehyde level was significantly reduced and Glutathione (GSH) level and catalase (CAT) activity were mildly increased compared to the ISO group. Elevation of GSH and CAT activity were more pronounced in ISO+HIVA group.
Conclusion: Our results indicate that both 1 mg/kg and 10 mg/kg doses of IVA were effective against heart damage induced by ISO via its negative chronotropic, anti-oxidant (dose dependent), anti-inflammatory and anti-degenerative properties.
Decoding the Indian Economic Slowdown: An Insight into the Factors behind the Stumble
Authors: Baranidharan S. 
Published: February 2023

Abstract
Purpose: The purpose of this study is to examine the economic challenges faced by the Indian economy in the past 12 years and the strategies implemented to overcome them, particularly in the context of the recent crisis and recession.
Design/methodology/approach: A qualitative research design was used, incorporating both secondary data sources, such as government reports, academic journals, and expert interviews. This approach provided a comprehensive understanding of the Indian economy during the past 12 years. The Economic statistics like the Consumer Price Index, GDP, Gross Savings and Investment Rates, Trade Ratio of GDP, Share of Manufacturing and Industry in GDP, and Bank NPA used to understand the causes of the slowdown.
Findings: The findings reveal that the Indian economy has faced significant challenges in recent years, particularly due to the COVID-19 pandemic, resulting in a decline in economic growth, consumer spending, investment, and exports. However, the study also discovered that the Indian economy has shown resilience in overcoming these challenges, with a rebound in 2021 due to government and monetary policy measures.
Research limitations/implications: The study has some limitations, including dependence on secondary data sources and a lack of comprehensive data on the pandemic's impact on the Indian economy. Further research is necessary to gain a more in-depth understanding of the challenges faced by the Indian economy and the efficacy of management strategies implemented.
Practical implications: The findings of this study have practical implications for policymakers and business leaders, highlighting the challenges faced by the Indian economy and the importance of effective management strategies to overcome them.
Social implications: The challenges faced by the Indian economy have significant social implications, affecting the livelihoods of millions and having a ripple effect on the wider economy. This study's findings provide important insight into the social impact of the recent crisis and recession on the Indian economy.
Originality/value: This study provides unique insights into the economic challenges faced by the Indian economy in the past 12 years and the strategies implemented to overcome them. It adds to the existing body of knowledge by offering a comprehensive analysis of the impact of the recent crisis and recession on the Indian economy.
JEL Codes: E32, E62, O23, O24.
Comparative Efficacy of Angiotensin Converting Enzymes Inhibitors and Angiotensin Receptor Blockers in Patients with Heart Failure in Tanzania: A Prospective Cohort Study
Authors: Mayala Mark , Mayala Henry , Khanbhai Khuzeima 
Published: February 2023

Abstract
Background

Heart failure has been a rising concern in Tanzania. New drugs have been introduced, including the group of drugs called Angiotensin receptor Neprilysin inhibitors (ARNI), but due to their high cost, angiotensin-converting enzymes inhibitors (ACEIs) and Angiotensin receptor blockers (ARBs) have been mostly used in Tanzania. However, according to our knowledge, the efficacy comparison of the two groups is yet to be studied in Tanzania. The aim of this study was to compare the efficacy of ACEIs and ARBs among patients with heart failure.

Methodology

This was a hospital-based prospective cohort study done at Jakaya Kikwete Cardiac Institution (JKCI), Tanzania, from June to December 2020. Consecutive enrollment was done until fulfilling the inclusion criteria. Clinical details were measured at baseline. We assessed the relationship between ARBs and ACEI users with N-terminal pro-Brain natriuretic peptide (NT pro-BNP) levels at admission and at 1-month follow-up using a chi-square test. A Kaplan-Meier curve was used to estimate the survival time of the two groups.

Results

155 HF patients were enrolled, with a mean age of 48 years, whereby 52.3% were male, and their mean left ventricular ejection fraction (LVEF) was 37.3%. 52 (33.5%) heart failure patients were on ACEIs, 57 (36.8%) on ARBs, and 46 (29.7%) were neither using ACEIs nor ARBs. At least half of the patients did not receive a Guideline directed medical therapy (GDMT), with only 82 (52.9%) receiving a GDMT. A drop in NT pro-BNP levels was observed during admission and at 1-month follow-up on both groups, from 6389.2pg/ml to 4000.1pg/ml for ARB users and 5877.7pg/ml to 1328.2pg/ml for the ACEIs users. There was no statistical difference between the two groups when estimated by the Kaplan-Meier curve, though, more deaths were observed in those who were neither on ACEIs nor ARBs, with a calculated P value of 0.01.

Conclusion

This study demonstrates that ACEIs have more efficacy and overall better clinical outcome than ARBs, but this should be taken under the patient-based case, considering the side effects of ACEIs and patients’ adherence.
The Effect of RAS/BRAF Mutation Status on Prognosis and Relapse Pattern in Early Stage Colon Cancers
Authors: Kunt Nazli , Araz Murat , Yildirim Mahmut Selman , Findik Siddika , Kocak Mehmet Zahid , Eryilmaz Melek Karakurt , Artac Mehmet 
Published: February 2023

Abstract
Purpose
It is known that the RAS and BRAF mutations are predictive for targeted therapies together with chemotherapy in the treatment of metastatic colon cancer and affect negatively the prognosis of the disease. In early stage cancer, however, there are limited studies in the literature about the relationship of this mutational condition with prognosis and relapse pattern of the disease. In this study, in addition to classical risk factors, we evaluated the effects of mutational status on the clinical pattern at recurrence and survival in early stage colon cancer.
Methods
Patients who diagnosed with early-stage colon cancer and when following up recurrence or metastasis was detected were included in this study. Patients were divided into two groups as positive and negative RAS/BRAF mutations. Mutation analysis was performed from the early stage tissue of the patients whose mutation was positive at the time of recurrence. The relationship between mutation status and progression-free survival (PFS), overall survival (OS), and relapse pattern was analyzed.
Results
The number of patients with positive and negative mutations in the early stage were 39 and 40, respectively. 69% of the patients in the mutant group and 70% of the patients in the wild group were in stage 3. Both OS (47.27 months vs. 67.53 months; p = 0.02) and PFS (25.12 vs. 38.13 months; p = 0.049) were statistically significantly lower in mutant patients. Most patients had distant metastases at the time of recurrence on both sides (61.5% vs. 62.5%, respectively). There was no significant difference between mutant and non-mutant patients in terms of distant metastasis and local recurrence rates (p = 0.657). In the mutation re-analysis performed from the early stage tissue of the patients with mutations in the metastatic period, 11.4% of the patients were found to have no mutations.
Conclusion
Presence of mutation in early stage colon cancer is associated with shorter OS and PFS. The mutational status did not have a significant effect on the recurrence pattern. Because of the discordance of early-stage and late-stage mutational status, it is recommended to perform mutation analysis from tissue at relapse, if possible.
Prognostic value of preoperative circulating tumor cells for hepatocellular carcinoma with portal vein tumor thrombosis: A propensity score analysis
Authors: Yu Jing-jing , Li Ya-ni , Shu Chang , Yang Hui-yuan , Huang Zhao , Tao Ran , Chen Yue-yue , Chen Xiao-ping , Xiao Wei 
Published: February 2023

Abstract
Purpose The role of circulating tumor cell (CTC) has not been fully understood in Hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT).
Methods In this retrospective analysis, 316 HCC patients who underwent hepatectomy and preoperative CTC detection were included. Forty-one pairs of matched HCC patients with/without PVTT were selected by a propensity score matching (PSM) analysis. The preoperative CTC counts were compared in patients of full cohort and PSM model respectively. While their associations with disease-free survival (DFS) and overall survival (OS) were further analyzed.
Results Before and after PSM analysis, the preoperative CTC counts in HCC with PVTT group were substantially higher than in HCC without PVTT group. In full cohort of patients and in PSM model, patients with CTC ≥ 2 showed significantly shorter OS and DFS than patients with CTC < 2. The outcome of HCC patients with PVTT could be well differentiated by preoperative CTC levels, HCC patients with CTC ≥ 2 had noticeably shorter OS (9.9 months vs. 24.6 months, P = 0.0003) and DFS (6.0 months vs. 12.3 months, P = 0.0041) than those with CTC < 2. Moreover, preoperative CTC ≥ 2 remained independent in all groups’ multivariate analysis.
Conclusion We discovered a link between preoperative CTC counts and the occurrence of PVTT, and confirmed the prognostic significance of preoperative CTC in HCC patients with PVTT. These findings suggested that preoperative CTC counts have the potential to assist in identifying patients with HCC and PVTT who may benefit from surgery.
TransitCrowd: Estimating Subway Stations Demand with Mobile Crowdsensing Data
Authors: Vitello Piergiorgio , Fiandrino Claudio , Connors Richard D. , Viti Francesco 
Published: February 2023

Abstract
Traditionally Public Transport (PT) demand estimation relies on manual survey-based or, where available, smartcard passenger data. However, even if these are precious data for researchers, providers and municipalities make it rarely available. The problem is poised to worsen accounting for the variety of formats and the low granularity in which such data is available. Only recently first steps towards the use of more advanced ICT-based data-driven approaches have started to emerge, which can provide new opportunities for generating more data and insights into transit demand patterns and behaviour.
In this paper, we tackle one specific instance of transit demand estimation, that of subway stations. We design and test the TransitCrowd tool, which estimates the transit users entering and exiting stations using as proxy the subway crowdness provided by Google Popular Times crowdsensed information that is available at sheer scale in any city. Then subway crowdness is mapped to the precise volume and temporal dynamics of entrances and exits profiles at the level of each subway station. TransitCrowd's key component is the one-time calibration which creates temporal signatures of the stations. We assess TransitCrowd's estimation accuracy for two cities across a two-months period, i.e., New York and Washington.
Transformationsprozesse und der Aufbau von (medialer) Gestaltungskompetenz zur nachhaltigen Entwicklung in Bildungsprozessen
Authors: Autenrieth Daniel , Nickel Stefanie 
Published: February 2023

Der Beitrag präsentiert das Entwicklungsprojekt «Expo Zukunft der Nachhaltigkeit digital und partizipativ» (ExpoNaDig partizipativ) sowie erste qualitativ erhobene projektbegleitende Forschungsergebnisse. Im Zentrum steht ein virtuell-kreativer Raum, mit dem Ziel der gemeinschaftlichen und offenen Gestaltung einer erweiterbaren digitalen Weltausstellung für eine nachhaltige Zukunft. Es geht darum, jungen Menschen (national wie global) eine Plattform zu geben, um prospektiv ihre Ideen und Wünsche visualisieren zu können sowie um aus den Visionen der nachwachsenden Generation (Unterrichts-)Material und Aktivitäten zur Stärkung von Gestaltungskompetenzen zugunsten einer Bildung für nachhaltige Entwicklung abzuleiten. ExpoNaDig möchte für eine zukunftsfähige Entwicklung im Zusammenspiel von Ökologie, Sozialem und Ökonomie die in Grundsatz 21 der Rio-Deklaration angesprochene geistig-schöpferische Dimension stärken, in der es darum geht, «die Kreativität, die Ideale und den Mut der jungen Menschen auf der ganzen Welt» zu mobilisieren. Der Beitrag untersucht anhand des Projektbeispiels die Fragen danach, wie junge Menschen Nachhaltigkeits-Kompetenzen entwickeln können, und untersucht dabei (organisationslogische) Strukturen und deren Auswirkungen auf pädagogisches sowie kreatives und partizipatives Handeln.
Factors influencing the use of rainwater for agricultural irrigation: the case of greenhouse agriculture in southeast Spain
Authors: López-Felices B. , Velasco-Muñoz J. F. , Aznar-Sánchez J. A. , Román-Sánchez I. M. 
Published: February 2023

Abstract
The availability and quality of water resources for agricultural irrigation are being increasingly compromised by different factors. In this context, the installation of rainwater harvesting (RWH) systems for use in agricultural holdings can contribute to mitigating this problem. However, the use of these systems by farmers continues to be very low. This paper analyses the factors that influence a farmer's decision to adopt these systems to take advantage of rainwater. Greenhouse agriculture in southeast Spain is the case studied. For this, a binary logistic regression model based on a survey administered to farmers was used. Among the variables found to be significant, the most important variables are the quantity of water in the pond, the pond capacity and environmental awareness. The variables that least affect the adoption decision are age, education level and income. These results have allowed the development of the main lines of action for policy-makers to intervene in order to promote the adoption of these systems. These measures focus on enhancing the training of farmers, providing them with financial support and boosting their environmental awareness. The results of this study lead to improved research on farmers’ behaviour and sustainable management of water resources in agriculture.
Distribution of multiple antibiotic-resistant Gram-negative bacteria in potable water from hand-dug wells in Iwo, Nigeria
Authors: Atobatele Bukola Oyerinola , Owoseni Abimbola 
Published: February 2023

AbstractThe provision of potable water is a global challenge. Infections caused by drinking contaminated water are a regular occurrence in developing countries. This study was carried out to determine Gram-negative bacterial distribution and antibiotic resistance in potable water from hand-dug wells within Iwo, Nigeria. Thirty hand-dug wells were randomly selected within Iwo for sampling carried out between October and December 2018. Bacteria identification was carried out using standard methods. The most probable number (MPN) and antibiotic resistance profile as well as Multiple Antibiotic Resistance Index (MARI) for these isolates were determined in addition to studying their haemolysis patterns on blood agar. Results showed that all the water samples from these hand-dug wells were highly contaminated. The highest value &gt;1,100+ was recorded for 21 samples. In addition, 11 genera of bacteria were isolated: Citrobacter, Enterobacter, Escherichia, Klebsiella, Morganella, Neisseria, Proteus, Providencia, Salmonella, Serratia and Pseudomonas. Antibiotic resistance to cefixime and cefuroxime were 92.6 and 90.9%, respectively. One hundred and sixty-nine (96.6%) isolates had a MARI greater than 0.2 and all showed haemolysis. Ingestion of this contaminated water has major public health implications. Hence, it is advisable that every individual should embark on in-house water treatment to avoid water-borne diseases.
Modeling climate change impact on the inflow of the Magat reservoir using the Soil and Water Assessment Tool (SWAT) model for dam management
Authors: Singson Czarimah L. , Alejo Lanie A. , Balderama Orlando F. , Bareng Jeoffrey Lloyd R. , Kantoush Sameh A. 
Published: February 2023

AbstractUnderstanding the impact of climate change on watersheds using hydrologic models is timely and vital to dam management. The study predicts changes in the inflow of the Magat reservoir using the Soil and Water Assessment Tool (SWAT) under the two Representative Concentration Pathway (RCP) scenarios for future centuries. The monthly calibration process (18 years) and validation process (10 years) of the model resulted in an NSE of 0.73, R2 of 0.74, RSR of 0.52, PBIAS of 8.38, NSE of 0.56, R2 of 0.62, RSR of 0.66, and a PBIAS of 17.3, respectively. Under RCP 4.5 and RCP 8.5 scenarios, the model predicted that during the dry and normal years, there will be an average decrease of inflow of 18.56 and 5.41% but an increase of 19.25% during the wet years. Peak flow will likely occur in September for all the scenarios, with a maximum discharge of up to 342.46 m3/s. The study recommends the integration of the model results to update the dam discharge protocol on the forecasting of monthly and annual inflows of the Magat dam to aid the dam management in observing long-term changes in the flow of water going into the reservoir.
Linking Phenotypes and Genotypes with Matrix Factorizations
Authors: Li Jianqiang , Guan Yu , Xu Xi , Ma Zerui , Pei Yan 
Published: February 2023

Aims:
We linked phenotypes and genotypes by PheGe-Net, a unified operation frame.

Background:
Genotype refers to the general name of all gene combinations of an individual. It
reflects the genetic composition of organisms. Phenotype refers to the macroscopic characteristics
of an organism that can be observed.

Objective:
Identifying the phenotype-genotype association assists in the explanation of the pathogenesis
and the progress of genomic medicine.

Methods:
PheGe-Net exploited the similarity net of phenotypes and genotypes and recognized
phenotype-genotype relationships to discover their hidden interactions.

Results:
By conducting experiments with a real-world dataset, the validity of our PheGe-Net is
verified. Our method outperformed the second-best one by around 3% on Accuracy and NMI
when clustering the phenotype/genotype; it also successfully detected phenotype-genotype associations,
for example, the association for obesity (OMIM ID: 601665) was analyzed, and among the
top ten scored genes, two known ones were assigned with scores more than 0.75, and other eight
predicted ones are also explainable.

Conclusion:
PheGe-Net is not only able to discover latent phenotype or genotype clusters but also
can uncover the hidden relationships among them, as long as there are known similarity networks
of phenotype, genotype, and acknowledged pheno-genotype relationships.
4-Nerolidylcatechol (4-NC) and Docetaxel Synergize in Controlling Androgen-
independent Prostate Cancer Cells
Authors: da Silva Guimarães Gabriela , Cordeiro Antonielle Oliveira , Gazolla Matheus Coutinho , Vecchi Lara , Pereira Zoia Mariana Alves , de Vasconcelos Azevedo Fernanda Van Petten , Moreira Campos Igor , de Souza Costa Danilo , Soares  Mota Sara Teixeira , Alves Ribeiro Matheus , Goulart Luiz Ricardo , da Silva Filho Ademar Alves , Araújo Thaise Gonçalves 
Published: February 2023

Background:
Effective cancer treatment still challenges medicine since the strategies employed so far are not sufficiently safe and capable of specifically eliminating tumor cells. Pros-tate cancer (PCa) is a highly incident malignant neoplasm, and the outcome of patients, especially those with advanced castration-resistant PCa (CRPC), depends directly on the efficacy of the thera-peutic agents, such as docetaxel (DOC).

Objective:
This study investigated the synergistic potentiation of 4-nerolidylcatechol (4-NC) with DOC in inhibiting androgen-independent PCa cells.

Methods:
The cytotoxic effect of 4-NC was evaluated against non-tumorigenic (RWPE-01) and PCa cell lines (LNCaP and PC-3), and the antiproliferative potential of 4-NC was assessed by flow cytometry and colony formation. The Chou-Talalay method was applied to detect the synergistic effect of 4-NC and DOC, and the mechanism of anticancer activities of this combination was inves-tigated by analyzing players in epithelial-mesenchymal transition (EMT).

Results:
4-NC significantly reduced the viability of PC-3 cells in a dose-dependent manner, de-creasing colony formation and proliferation. The combination of 4-NC and DOC was synergistic in the androgen-independent cells and allowed the reduction of DOC concentration, with increased cy-totoxicity and induction of apoptosis when compared to compounds alone. Furthermore, when 4-NC was co-administered with DOC, higher expression levels of proteins associated with the epithe-lial phenotype were observed, controlling EMT in PC-3 cells.

Conclusion:
Collectively, these data demonstrated, for the first time, that the combination of 4-NC with reduced doses of DOC could be especially valuable in the suppression of oncogenic mecha-nisms of androgen-independent PCa cells.