bluuebunny/crossref_metadata_2025_split huggingface dataset:
Das Lehrnetzwerk Migration und Gesundheit: Aus- und Weiterbildung konsolidieren und weiterentwickeln
Authors: Führer Amand , Taché Stephanie , Riemenschneider Henna , Bozorgmehr Kayvan , Diaz-Monsalve Sonia , Knipper Michael , Mews Claudia , Schwienhorst-Stich Eva-Maria , Siebert Ute , Strelow Kai-Uwe , Ziegler Sandra 
Published: September 2023

ZusammenfassungPatient*innen mit Migrationsgeschichte stoßen im deutschen Gesundheitssystem vielfach auf Zugangsbarrieren, die die Qualität der ihnen zugänglichen Versorgung mindern und ihre Gesundheit beeinträchtigen. Diese Barrieren haben einerseits politische Ursachen, sind jedoch auch auf einen Mangel an migrations- und diversitätsbezogenen Inhalten im Medizinstudium und in anderen gesundheitsbezogenen Studien- und Ausbildungsgängen zurückzuführen. Obwohl die Versorgung von Patientinnen und Patienten mit eigener oder familiärer Migrationsgeschichte zum Alltag gehört, sind dafür relevante Inhalte bislang nicht in den Curricula verankert und werden bestenfalls in Form von Wahlpflichtfächern oder anderen fakultativen Lehrangeboten vermittelt.Um diese Situation zu verbessern und eine menschenrechtsbasierte, diversitätssensible und Equity-orientierte Weiterentwicklung der Curricula voranzutreiben, hat sich das „Lehrnetzwerk Migration und Gesundheit“ gegründet. Es zielt darauf ab, 1) in der Lehre aktive Personen miteinander zu vernetzen und den Austausch sowie die gemeinsame Weiterentwicklung von Lehrmaterial zu fördern, 2) darauf aufbauend einen Modellkurs „Migration und Gesundheit“ zu entwickeln und 3) Strategien für die longitudinale Implementierung entsprechender Inhalte in Pflichtcurricula zu erarbeiten. Diese Bestrebungen werden von Lehrforschung flankiert. An Mitarbeit im Lehrnetzwerk Interessierte sind herzlich eingeladen, die Autor*innen zu kontaktieren und an diesen Vorhaben mitzuwirken.
Patterns of PET-positive residual tissue at interim restaging and risk of treatment failure in advanced-stage Hodgkin’s lymphoma: an analysis of the randomized phase III HD18 trial by the German Hodgkin Study Group
Authors: Ferdinandus Justin , van Heek Lutz , Roth Katrin , Dietlein Markus , Eich Hans-Theodor , Baues Christian , Borchmann Peter , Kobe Carsten 
Published: September 2023

Abstract
Purpose
Response-adapted treatment using early interim functional imaging with PET after two cycles of chemotherapy (PET-2) for advanced-stage Hodgkin’s lymphoma (AS-HL) is the standard of care in several countries. However, the distribution of residual metabolic disease in PET-2 and the prognostic relevance of multiple involved regions have not been reported to date.

Methods
We retrospectively analyzed data from all PET-2-positive patients included in HD18. Residual tissue was visually compared with reference regions according to the Deauville score (DS). PET-2 positivity was defined as residual tissue with uptake above the liver (DS4). PFS was defined as the time from staging until progression, relapse, or death from any cause, or to the day when information was last received on the patient’s disease status and analyzed using Kaplan-Meier and Cox regressions. Comparisons were made between patients with 1–2 and >2 positive regions in PET-2 as well as patients without PET-2-positive regions randomized into comparator arms of HD18.

Results
Between 2008 and 2014, 1964 patients with newly diagnosed AS-HL were recruited in HD18 and randomized following their PET-2 scan. Of these, 480 patients had a positive PET-2 and were eligible for this analysis. Upper and lower mediastinum in almost half of all patients: 230 (47.9%) and 195 (40.6%), respectively. 372 (77.5%) of patients have 1–2 positive regions in PET-2. 5y-PFS for patients with 1–2 regions was 91.7% (CI95: 88.7–94.6) vs. 81.8% (CI95: 74.2–90.1) for those with >2 regions with a corresponding hazard ratio (HR) of 2.2 (CI95: 1.2–4.0). Compared with patients without PET-2-positive disease receiving 6–8 cycles of chemotherapy, patients with 1–2 had a higher risk for a PFS event (HR 1.35; CI95 0.81–2.28), but it was not statistically significant (p=0.25). Patients with >2 PET-2-positive lesions had a significantly higher risk (HR 2.95; CI95: 1.62–5.37; p<0.001).

Conclusion
PET-2-positive residuals of AS-HL are mostly located in the mediastinum, and a majority of patients have few affected regions. The risk of progression was twofold higher in patients with more than two positive regions in PET-2.
Effects of matcha tea extract on cell viability and estrogen receptor-β expression on MCF-7 breast cancer cells
Authors: Keckstein Simon , Tilgener Constantin , Jeschke Udo , Hofmann Simone , Vilsmaier Theresa , Keilmann Lucia , Heidegger Helene , Kaltofen Till , Batz Falk , Mahner Sven , Schröder Lennard 
Published: September 2023

Abstract
Purpose
In the following work, we investigated the effect of matcha green tea extract (MTE) on MCF-7 breast cancer cell viability and estrogen receptor-beta expression (ERβ).

Methods
MCF-7 cells were stimulated with MTE at concentrations of 5 and 10 µg/ml. Cell viability was assessed using a water-soluble tetrazolium assay (WST-1 assay) after an incubation time of 72 h. ERβ was quantified at gene level by real-time polymerase chain reaction (PCR). A western blot (WB) was carried out for the qualitative assessment of the expression behavior of on a protein level.

Results
The WST-1 test showed a significant inhibition of viability in MFC-7 cells after 72 h at 10 µg/ml. The WB demonstrated a significant quantitative decrease of ERβ at protein level with MTE concentrations of 10 µg/ml. In contrast, the PCR did not result in significant downregulation of ERβ.

Conclusion
MTE decreases the cell viability of MCF-7 cells and furthermore leads to a decrease of ERβ at protein level.
Boron-doped diamond nanosheet volume-enriched screen-printed carbon electrodes: a platform for electroanalytical and impedimetric biosensor applications
Authors: Ficek Mateusz , Cieślik Mateusz , Janik Monika , Brodowski Mateusz , Sawczak Mirosław , Bogdanowicz Robert , Ryl Jacek 
Published: September 2023

AbstractThis paper focuses on the development of a novel electrode based on boron-doped diamond nanosheet full-volume-enriched screen-printed carbon electrodes (BDDPE) for use as an impedimetric biosensor. Impedimetric biosensors offer high sensitivity and selectivity for virus detection, but their use as point-of-care devices is limited by the complexity of nanomaterials’ architecture and the receptor immobilisation procedures. The study presents a two-step modification process involving the electroreduction of diazonium salt at the BDDPE and the immobilisation of antibodies using zero-length cross-linkers for a selective impedimetric biosensor of Haemophilus influenzae (Hi). The incorporation of diamond nanosheets into BDDPE leads to enhanced charge transfer and electrochemical behaviour, demonstrating greatly improved electrochemically active surface area compared with unmodified screen-printed electrodes (by 44% and 10% on average for [Ru(NH3)6]Cl2 and K3[Fe(CN)6], respectively). The presented sensing system shows high specificity towards protein D in Hi bacteria, as confirmed by negative controls against potential interference from other pathogens, with an estimated tolerance limit for interference under 12%. The Hi limit of detection by electrochemical impedance spectroscopy was 1 CFU/mL (measured at − 0.13 V vs BDDPE pseudo-reference), which was achieved in under 10 min, including 5 min sample incubation in the presence of the analyte.
Graphical abstract
Cytogeography of Gagea bohemica (Liliaceae) outside the Mediterranean: two ploidy levels, spatial differentiation of cytotypes, and occurrence of mixed-ploidy populations
Authors: Horák David , Trávníček Bohumil , Király Gergely , Détraz-Méroz Jacqueline , Vymyslický Tomáš , Kozoni Marianthi , Harpke Dörte , Hroneš Michal 
Published: September 2023

AbstractGagea bohemica s.l. is a morphologically and karyologically highly variable group with many morphologically similar “narrow” taxa currently considered as a single variable species. It is predominantly distributed in Mediterranean and warmer parts of temperate belt of Europe. The large-scale data on its cytogeography and population cytotype structure which could provide a basis for taxonomy are lacking, only scattered data on ploidy have been published from various parts of its range. In this study, we sampled 106 populations in broader Central Europe, the northeastern Balkan Peninsula and the northwestern Black Sea coast in order to analyze their ploidy level, genome size and pollen stainability. Two cytotypes, i.e., tetraploid (2n = 48) and pentaploid (2n = 60), were found in the study area using chromosome counting and flow cytometry, both in pure and mixed-ploidy populations. Pure pentaploid populations are mainly distributed in Austria, Czechia, northwestern Hungary and Slovakia while tetraploid cytotype in pure and mixed-ploidy populations forming two lineages which are concentrated into two disjunct geographical areas: a western lineage in Germany and Switzerland and an eastern one in Bulgaria, southeastern Hungary, northern Greece, Romania, Serbia and Ukraine. The two lineages differ in their genome size regardless of their ploidy, indicating their independent origin. Analysis of pollen stainability using a modified Alexander stain revealed an unusual pattern with tetraploids having a lower pollen stainability (mean 44.29%) than pentaploids (mean 70.70%), but the western and eastern populations differed again from each other.
Lebensbedrohliche Verätzungen und Atemwegsschwellung nach Trinken von Rohrreiniger
Authors: Suárez Victor , Strom Olga , Blomeyer Ralf , Hamacher Laura , Hüser Christoph , Sieg Noëlle , Hackl Matthias Johannes , Burst Volker 
Published: September 2023

ZusammenfassungVergiftungen mit im Haushalt verfügbaren Chemikalien sind im Erwachsenenalter selten und kommen meist in suizidaler Absicht vor. Die in Rohrreinigern enthaltenen Substanzen bilden bei Kontakt mit Wasser stark ätzende Laugen, bei der Reaktion entsteht außerdem große Hitze. Im vorliegenden Fall kam es nach Ingestion verhältnismäßig geringer Mengen von Rohrreiniger zu ausgeprägten Verletzungen des Gastrointestinaltrakts sowie zur Entwicklung einer lebensbedrohlichen Atemwegsschwellung und Aspiration. Essenziell ist daher – neben Maßnahmen der Dekontamination und Kreislaufstabilisierung – eine rechtzeitige Sicherung der Atemwege. Die Patienten sollten schnellstmöglich in einem Krankenhaus mit 24 h-Gastroskopiebereitschaft vorgestellt werden.
On efficiency and the Jain’s fairness index in integer assignment problems
Authors: Rezaeinia Nahid , Góez Julio C. , Guajardo Mario 
Published: September 2023

AbstractGiven two sets of objects, the integer assignment problem consists of assigning objects of one set to objects in the other set. Traditionally, the goal of this problem is to find an assignment that minimizes or maximizes a measure of efficiency, such as maximization of utility or minimization of cost. Lately, the interest in incorporating a measure of fairness in addition to efficiency has gained importance. This paper studies how to incorporate these two criteria in an integer assignment, using the Jain’s index as a measure of fairness. The original formulation of the assignment problem with this index involves a non-concave function, which renders a non-linear non-convex problem, usually hard to solve. To this aim, we develop two reformulations, where one is based on a quadratic objective function and the other one is based on integer second-order cone programming. We explore the performance of these reformulations in instances of real-world data derived from an application of assigning personnel to projects, and also in instances of randomly generated data. In terms of solution quality, all formulations prove to be effective in finding solutions capturing both efficiency and fairness criteria, with some slight differences depending on the type of instance. In terms of solving time, however, the performances of the formulations differ considerably. In particular, the integer quadratic approach proves to be much faster in finding optimal solutions.
Adapting a multiscale approach to assess the compositional diversity of landscapes
Authors: Konrád Krisztina Dóra , Bede-Fazekas Ákos , Bartha Sándor , Somodi Imelda 
Published: September 2023

Abstract
Context
The role of landscape diversity and structure is crucial for maintaining biodiversity. Both landscape diversity and structure have often been analysed on one thematic layer, focusing on Shannon diversity. The application of compositional diversity, however, has received little attention yet.

Objectives
Our main goal was to introduce a novel framework to assess both landscape compositional diversity and structure in one coherent framework. Moreover, we intended to demonstrate the significance of the use of a neutral model for landscape assessments.

Methods
Both entire Hungary and nine of its regions were used as study areas. Juhász-Nagy’s information theory-based functions, i.e. “compositional diversity” and “associatum”, were introduced and applied in landscape context. Potential and actual landscape characteristics were compared by analysing a probabilistic representation of potential natural vegetation (multiple PNV, MPNV) and actual vegetation (AV), treating MPNV as a neutral model.

Results
A significant difference was found between the MPNV- and AV-based, maximal compositional diversity estimates. MPNV-based maximal compositional diversity was higher and the maximum appeared at a finer spatial scale. The differences were more prominent in human-modified regions. Associatum implied the spatial aggregation of both MPNV and AV. Fragmentation of AV was indicated by larger units carrying maximal compositional diversity and maximal associatum values.

Conclusions
Applying the multiscale Juhász-Nagy’s functions to landscape composition allowed more precise characterization of the landscape state than traditional Shannon diversity. Our results underline, that increasingly transformed landscapes host decreasing complexity of vegetation type combinations and increasing grain that carries the richest information on landscape vegetation patterns.
Multi-objective optimization for timber harvest management incorporating wildlife habitat goals
Authors: Schooler Sarah L. , Svoboda Nathan J. , Kroll Charles N. , Finnegan Shannon P. , Belant Jerrold L. 
Published: September 2023

Abstract
Context
The forestry industry provides important goods, services and economic benefits, but timber harvest can adversely impact ecosystem services, including wildlife habitat. Timber harvest planning can integrate wildlife habitat quality through multi-objective optimization for timber harvest and wildlife habitat suitability.

Objectives
Our objective was to develop a method to find optimal solutions for timber harvest and wildlife habitat suitability individually and concurrently, then apply the method to Roosevelt elk (Cervus elaphus roosevelti) on Afognak Island, Alaska.

Methods
We developed three seasonal habitat suitability models using elk locations and landscape variables including historical timber harvest on Afognak Island, Alaska. We used threshold-accepting optimization over a 50-year planning horizon to maximize timber harvest yield and habitat suitability in each season, then used multi-objective goal-deviation optimization to simultaneously maximize timber harvest volume and seasonal habitat suitability.

Results
The optimal solution for timber yield decreased seasonal average habitat suitability by 5.7%. Elk habitat suitability and corresponding optimal solutions varied seasonally; elk generally selected open landcovers and early- to mid-successional timber stands over late-successional and mature stands. Therefore, in the optimal solutions, stands were harvested before they reached maximum volume and few stands were harvested in early planning periods, resulting in a seasonal average loss of 17.5% yield. Multi-objective optimization decreased seasonal average suitability by 3.9% and yield by 1.4% compared to single-objective optimization.

Conclusions
Our multi-objective optimization approach that incorporates data-driven habitat suitability models using open-source software can enable managers to achieve desired quantity and quality of wildlife habitat while providing for resource extraction.
Long COVID quality of life and healthcare experiences in the UK: a mixed method online survey
Authors: Owen Rebecca , Ashton Ruth E. , Skipper Lindsay , Phillips Bethan E. , Yates James , Thomas Callum , Ferraro Francesco , Bewick Tom , Haggan Kate , Faghy Mark A. 
Published: September 2023

Abstract
Purpose
The complexity of long COVID and its diverse symptom profile contributes to unprecedented challenges for patients, clinicians, and healthcare services. The threat of long COVID remains ignored by Governments, the media and public health messaging, and patients’ experiences must be heard through understanding of the lived experience. This study aimed to understand the lived experience of those living with long COVID.

Methods
An online web-based survey was designed using Patient and Public Involvement and Engagement (PPIE) to increase understanding of the lived experiences of long COVID, and was distributed through PPIE groups, social media, and word of mouth. The survey used closed and open questions relating to demographics, pre- and post-COVID-19 health quality of life, daily activities and long COVID experiences.

Results
Within our sample of 132 people living with long COVID, the findings highlight that individuals are being severely impacted by their symptoms and are unable to or limited in participating in their daily activities, reducing quality of life. Long COVID places strain on relationships, the ability to live life fully and is detrimental to mental health. Varying health care experiences are described by participants, with reports of medical gaslighting and inadequate support received.

Conclusions
Long COVID has a severe impact on the ability to live life fully, and strains mental health. The appropriate mechanisms and support services are needed to support those living with long COVID and manage symptoms.
Oppy on arguments and worldviews: an internal critique
Authors: Békefi Bálint 
Published: September 2023

AbstractThis paper develops an internal critique of Graham Oppy’s metaphilosophy of religion – his theories of argumentation, worldview comparison, and epistemic justification. First, it presents Oppy’s views and his main reasons in their favor. Second, it argues that Oppy is committed to two claims – that only truth-conducive reasons can justify philosophical belief and that such justification depends entirely on one’s judgments about the theoretical virtues of comprehensive worldviews – that jointly entail the unacceptable conclusion that philosophical beliefs cannot be justified. Third, it briefly argues that of his two claims, it is his thoroughgoing coherentism that should be rejected.
Axial curvatures for corank 1 singular n-manifolds in $${{\mathbb {R}}}^{n+k}$$
Authors: Benedini Riul P. , Deolindo-Silva J. L. , Oset Sinha R. 
Published: September 2023

AbstractFor singular n-manifolds in $${{\mathbb {R}}}^{n+k}$$

R

n
+
k

with a corank 1 singular point at $$p\in M^n_{{\text {sing}}}$$

p
∈

M
sing
n

we define up to $$l(n-1)$$

l
(
n
-
1
)

different axial curvatures at p, where $$l=\min \{n,k+1\}.$$

l
=
min
{
n
,
k
+
1
}
.

These curvatures are obtained using the curvature locus (the image by the second fundamental form of the unitary tangent vectors) and are therefore second order invariants. In fact, in the case $$n=2$$

n
=
2

they generalise all second order curvatures which have been defined for frontal type surfaces. We relate these curvatures with the principal curvatures in certain normal directions of an associated regular $$(n-1)$$

(
n
-
1
)

-manifold contained in $$M^n_{{\text {sing}}}.$$

M
sing
n

.

We obtain many interesting geometrical interpretations in the cases $$n=2,3.$$

n
=
2
,
3
.

For instance, for frontal type 3-manifolds with 2-dimensional singular set, the Gaussian curvature of the singular set can be expressed in terms of the axial curvatures. Similarly for the curvature of the singular set when it is 1-dimensional. Finally, we show that all the umbilic curvatures which have been defined for singular manifolds up to now can be seen as the absolute value of one of our axial curvatures.
The derived Brauer map via twisted sheaves
Authors: Nocera Guglielmo , Pernice Michele 
Published: September 2023

AbstractLet X be a quasicompact quasiseparated scheme. The collection of derived Azumaya algebras in the sense of Toën forms a group, which contains the classical Brauer group of X and which we call $$\textsf{Br}^\dagger (X)$$

Br
†

(
X
)

following Lurie. Toën introduced a map $$\phi :\textsf{Br}^\dagger (X)\rightarrow H ^2_{\acute{e }t }(X,{\mathbb {G}}_{\textrm{m}})$$

ϕ
:

Br
†

(
X
)

→

H

e
´

t

2

(
X
,

G
m

)

which extends the classical Brauer map, but instead of being injective, it is surjective. In this paper we study the restriction of $$\phi $$
ϕ
to a subgroup $$\textsf{Br}(X)\subset \textsf{Br}^\dagger (X)$$

Br

(
X
)

⊂

Br
†

(
X
)

, which we call the derived Brauer group, on which $$\phi $$
ϕ
becomes an isomorphism $$\textsf{Br}(X)\simeq H ^2_{\acute{e }t }(X,{\mathbb {G}}_{\textrm{m}})$$

Br

(
X
)

≃

H

e
´

t

2

(
X
,

G
m

)

. This map may be interpreted as a derived version of the classical Brauer map which offers a way to “fill the gap” between the classical Brauer group and the cohomogical Brauer group. The group $$\textsf{Br}(X)$$

Br
(
X
)

was introduced by Lurie by making use of the theory of prestable $$\infty $$
∞
-categories. There, the mentioned isomorphism of abelian groups was deduced from an equivalence of $$\infty $$
∞
-categories between the Brauer space of invertible presentable prestable $${{\mathcal {O}}}_X$$

O
X

-linear categories, and the space $$Map (X,K ({\mathbb {G}}_{\textrm{m}},2))$$

M
a
p
(
X
,
K

(

G
m

,
2
)

)

. We offer an alternative proof of this equivalence of $$\infty $$
∞
-categories, characterizing the functor from the left to the right via gerbes of connective trivializations, and its inverse via connective twisted sheaves. We also prove that this equivalence carries a symmetric monoidal structure, thus proving a conjecture of Binda an Porta.
The Infidelity Protection Nature of Romantic Jealousy: Testing Five Predictions in the Greek Cultural Context
Authors: Apostolou Menelaos , Tzannetatou Georgia 
Published: September 2023

AbstractRomantic jealousy can lead to several negative outcomes, such as tensions between intimate partners, domestic violence, and even homicide. On the other hand, it has been hypothesized that this mechanism has a protective effect against infidelity. In the current research, we aimed to examine five predictions derived from this hypothesis. Specifically, we conducted a study with a sample of N = 333 Greek-speaking participants who were in an intimate relationship. Our findings revealed that intimate partners’ jealousy was predicted by discrepancies in mate value, attitudes toward cheating, and interactions with individuals of the opposite sex. Notably, the latter effect was observed exclusively among male participants. Furthermore, we found that an intimate partner exhibiting higher romantic jealousy was associated with reduced freedom to flirt with others. This effect was both direct and indirect, mediated by an increased fear of their partner’s reactions.