bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fe3O4@nano-almondshell/Si(CH2)3/2-(1-piperazinyl)ethylamine as an effective magnetite almond shell-based nanocatalyst for the synthesis of dihydropyrano[3,2-c]chromene and tetrahydrobenzo[b]pyran derivatives
Authors: Mallah Dina , Mirjalili Bi Bi Fatemeh , Bamoniri Abdolhamid 
Published: April 2023

AbstractThe preparation and design of nano-catalysts based on magnetic biopolymers as green and biocompatible nano-catalysts have made many advances. This paper deals with the preparation of magnetite biopolymer-based Brønsted base nano-catalyst from a nano-almond (Prunus dulcis) shell. This magnetite biopolymer-based nano-catalyst was obtained through a simple process based on the core-shelling of nano-almond shell and Fe3O4NPs and then the immobilization of 3-chloropropyltrimethoxysilane as linker and 2-aminoethylpiperazine as a basic section. Structural and morphological analysis of this magnetite biopolymer-based nano-catalyst were done using Fourier transform infrared spectroscopy, field emission scanning electron microscopy, X-ray diffraction, Thermogravimetric analysis, Vibrating sample magnetization, Energy-dispersive X-ray spectroscopy, Brunauer–Emmett–Teller, and Transmission electron microscopy techniques. The performance of the synthesized Fe3O4@nano-almondshell/Si(CH2)3/2-(1-piperazinyl)ethylamine as a novel magnetite biopolymer-based nano-catalyst for the synthesis of dihydropyrano[3,2-c]chromene and tetrahydrobenzo[b]pyran was investigated and showed excellent efficiency.
Qualitative study on diabetic cutaneous wound healing with radiation crosslinked bilayer collagen scaffold in rat model
Authors: Li Hongwei , Chen Xin , Ren Kang , Wu Lihao , Chen Gong , Xu Ling 
Published: April 2023

AbstractDiabetes may leave patients more prone to skin problems, and minor skin conditions can more easily turn into serious damage to the extracellular matrix, which further impairs the skin's mechanical properties and delays wound healing. Therefore, the aim of the work is to develop extracellular matrix substitution to remodel the mechanical properties of diabetic cutaneous wound and thus accelerate diabetic wound healing. A green fabrication approach was used to prepare radiation crosslinked bilayer collagen scaffold from collagen dispersion. The morphological, mechanical and swelling characteristics of radiation crosslinked bilayer collagen scaffold were assessed to be suitable for cutaneous wound remodeling. The feasibility of radiation crosslinked bilayer collagen scaffold was performed on full-skin defect of streptozotocin-induced diabetic rats. The tissue specimens were harvested after 7, 14, and 21 days. Histopathological analysis showed that radiation crosslinked bilayer collagen scaffold has beneficial effects on inducing skin regeneration and remodeling in diabetic rats. In addition, immunohistochemical staining further revealed that the radiation crosslinked bilayer collagen scaffold could not only significantly accelerate the diabetic wound healing, but also promote angiogenesis factor (CD31) production. Vascularization was observed as early as day 7. The work expands the therapeutic ideas for cutaneous wound healing in diabetes.
Clinical results of autologous protein solution injection for knee osteoarthritis with severe disease grade is inferior to mild or moderate grade
Authors: Kuwasawa Ayano , Okazaki Ken , Noda Kuniko , Nihei Kotaro 
Published: April 2023

AbstractAutologous protein solution (APS) is made from platelet-rich plasma that extracts high-concentration growth factors and cytokines. Intra-articular APS injection was reported to improve knee osteoarthritis (KOA) pain and function. However, efficacy differences regarding osteoarthritis severity remained unknown. This retrospective study clinically assessed 220 knees with KOA in the Kellgren–Lawrence (KL) grades 2–4 that underwent APS injection using the Knee Injury and Osteoarthritis Outcome Score (KOOS). A telephone survey was performed for patients who dropped out to check symptom changes. The recalculated estimated responder rate included the telephone survey results. The 12-month follow-up was completed with 148 knees (67%), whereas 72 knees dropped out. The follow-up rate was significantly lower in KL4 than KL2 and 3. The KOOS significantly improved in 148 knees, whereas the KOOS was lower in KL4 than in KL2. The responder rate was 55% total, 58% in KL2, 57% in KL3, and 47% in KL4; however, the estimated responder rate, including the telephone survey, was 49% total, 55% in KL2, 54% in KL3, and 36% in KL4. This study showed improved clinical symptoms 1-year after APS injections for KOA, with a lower responder rate in KL4 than in KL2 or KL3.
Eardrum-inspired soft viscoelastic diaphragms for CNN-based speech recognition with audio visualization images
Authors: Park Seok-Jin , Lee Hee-Beom , Kim Gi-Woo 
Published: April 2023

AbstractIn this study, we present initial efforts for a new speech recognition approach aimed at producing different input images for convolutional neural network (CNN)-based speech recognition. We explored the potential of the tympanic membrane (eardrum)-inspired viscoelastic membrane-type diaphragms to deliver audio visualization images using a cross-recurrence plot (CRP). These images were formed by the two phase-shifted vibration responses of viscoelastic diaphragms. We expect this technique to replace the fast Fourier transform (FFT) spectrum currently used for speech recognition. Herein, we report that the new creation method of color images enabled by combining two phase-shifted vibration responses of viscoelastic diaphragms with CRP shows a lower computation burden and a promising potential alternative way to STFT (conventional spectrogram) when the image resolution (pixel size) is below critical resolution.
LipidOz enables automated elucidation of lipid carbon–carbon double bond positions from ozone-induced dissociation mass spectrometry data
Authors: Ross Dylan H. , Lee Joon-Yong , Bilbao Aivett , Orton Daniel J. , Eder Josie G. , Burnet Meagan C. , Deatherage Kaiser Brooke L. , Kyle Jennifer E. , Zheng Xueyun 
Published: April 2023

AbstractLipids play essential roles in many biological processes and disease pathology, but unambiguous identification of lipids is complicated by the presence of multiple isomeric species differing by fatty acyl chain length, stereospecifically numbered (sn) position, and position/stereochemistry of double bonds. Conventional liquid chromatography-mass spectrometry (LC-MS/MS) analyses enable the determination of fatty acyl chain lengths (and in some cases sn position) and number of double bonds, but not carbon-carbon double bond positions. Ozone-induced dissociation (OzID) is a gas-phase oxidation reaction that produces characteristic fragments from lipids containing double bonds. OzID can be incorporated into ion mobility spectrometry (IMS)-MS instruments for the structural characterization of lipids, including additional isomer separation and confident assignment of double bond positions. The complexity and repetitive nature of OzID data analysis and lack of software tool support have limited the application of OzID for routine lipidomics studies. Here, we present an open-source Python tool, LipidOz, for the automated determination of lipid double bond positions from OzID-IMS-MS data, which employs a combination of traditional automation and deep learning approaches. Our results demonstrate the ability of LipidOz to robustly assign double bond positions for lipid standard mixtures and complex lipid extracts, enabling practical application of OzID for future lipidomics.
Effect of aliovalent bismuth substitution on structure and optical properties of CsSnBr3
Authors: Chaudhary Madhusudan , Karmakar Abhoy , Mishra Vidyanshu , Bhattacharya Amit , Mumbaraddi Dundappa , Mar Arthur , Michaelis Vladimir K. 
Published: April 2023

AbstractAliovalent substitution of the B component in ABX3 metal halides has often been proposed to modify the band gap and thus the photovoltaic properties, but details about the resulting structure have remained largely unknown. Here, we examine these effects in Bi-substituted CsSnBr3. Powder X-ray diffraction (XRD) and solid-state 119Sn, 133Cs and 209Bi nuclear magnetic resonance (NMR) spectroscopy were carried out to infer how Bi substitution changes the structure of these compounds. The cubic perovskite structure is preserved upon Bi-substitution, but with disorder in the B site occurring at the atomic level. Bi atoms are randomly distributed as they substitute for Sn atoms with no evidence of Bi segregation. The absorption edge in the optical spectra shifts from 1.8 to 1.2 eV upon Bi-substitution, maintaining a direct band gap according to electronic structure calculations. It is shown that Bi-substitution improves resistance to degradation by inhibiting the oxidation of Sn.
Rapid differentiation of soil and root microbiomes in response to plant composition and biodiversity in the field
Authors: Burrill Haley M , Wang Guangzhou , Bever James D 
Published: April 2023

AbstractResearch suggests that microbiomes play a major role in structuring plant communities and influencing ecosystem processes, however, the relative roles and strength of change of microbial components have not been identified. We measured the response of fungal, arbuscular mycorrhizal fungal (AMF), bacteria, and oomycete composition 4 months after planting of field plots that varied in plant composition and diversity. Plots were planted using 18 prairie plant species from three plant families (Poaceae, Fabaceae, and Asteraceae) in monoculture, 2, 3, or 6 species richness mixtures and either species within multiple families or one family. Soil cores were collected and homogenized per plot and DNA were extracted from soil and roots of each plot. We found that all microbial groups responded to the planting design, indicating rapid microbiome response to plant composition. Fungal pathogen communities were strongly affected by plant diversity. We identified OTUs from genera of putatively pathogenic fungi that increased with plant family, indicating likely pathogen specificity. Bacteria were strongly differentiated by plant family in roots but not soil. Fungal pathogen diversity increased with planted species richness, while oomycete diversity, as well as bacterial diversity in roots, decreased. AMF differentiation in roots was detected with individual plant species, but not plant family or richness. Fungal saprotroph composition differentiated between plant family composition in plots, providing evidence for decomposer home-field advantage. The observed patterns are consistent with rapid microbiome differentiation with plant composition, which could generate rapid feedbacks on plant growth in the field, thereby potentially influencing plant community structure, and influence ecosystem processes. These findings highlight the importance of native microbial inoculation in restoration.
The effect of wheat genotype on the microbiome is more evident in roots and varies through time
Authors: Quiza Liliana , Tremblay Julien , Pagé Antoine P , Greer Charles W , Pozniak Curtis J , Li Rong , Haug Brenda , Hemmingsen Sean M , St-Arnaud Marc , Yergeau Etienne 
Published: April 2023

Abstract
Crop breeding has traditionally ignored the plant-associated microbial communities. Considering the interactions between plant genotype and associated microbiota is of value since different genotypes of the same crop often harbor distinct microbial communities which can influence the plant phenotype. However, recent studies have reported contrasting results, which led us to hypothesize that the effect of genotype is constrained by growth stages, sampling year and plant compartment. To test this hypothesis, we sampled bulk soil, rhizosphere soil and roots of 10 field-grown wheat genotypes, twice per year, for 4 years. DNA was extracted and regions of the bacterial 16 S rRNA and CPN60 genes and the fungal ITS region were amplified and sequenced. The effect of genotype was highly contingent on the time of sampling and on the plant compartment sampled. Only for a few sampling dates, were the microbial communities significantly different across genotypes. The effect of genotype was most often significant for root microbial communities. The three marker genes used provided a highly coherent picture of the effect of genotype. Taken together, our results confirm that microbial communities in the plant environment strongly vary across compartments, growth stages, and years, and that this can mask the effect of genotype.
Hygrothermal ageing characterisation of epoxy resin based on transmission characteristics of microwave resonator with interdigital‐capacitor‐shaped defected ground structure
Authors: Xiao Mi , Zhang Wei , Wang Xuguang 
Published: April 2023

AbstractIn this article, a method is proposed for the characterisation of epoxy resin thermal and hygrothermal ageing based on microwave resonator with interdigital‐capacitor‐shaped defected ground structure (IDCS‐DGS), which can realise rapid and simple non‐destructive testing of the ageing degree of epoxy resin materials. The resonant frequency of IDCS‐DGS was proved to decrease with the increase of dielectric constant of the around material by means of simulation. The breakdown test at high voltage showed the deterioration of epoxy resin after hygrothermal ageing, which is caused by moisture absorption and hydrolysis process. In addition, thermal ageing also caused a decline in the insulation performance of epoxy resin samples. Accelerated oxidation of epoxy resin samples at high temperatures produces polar molecules that increase the dielectric constant of the samples. As for the hygrothermal ageing samples, the entrance of polar water molecules will increase the dielectric constant of epoxy resin, and thus make an effect on the resonant frequency of IDCS‐DGS. The tests of transmission performance show that after the hygrothermally aged epoxy resin samples were put on the microwave sensor, the resonant frequency decreased continuously with hygrothermal ageing time, and the deviations of resonant frequency are highly consistent with the weight variation rate of the samples.
KMT-2021-BLG-2010Lb, KMT-2022-BLG-0371Lb, and KMT-2022-BLG-1013Lb: Three microlensing planets detected via partially covered signals
Authors: Han Cheongho , Lee Chung-Uk , Zang Weicheng , Jung Youn Kil , Christie Grant W. , Zhang Jiyuan , Albrow Michael D. , Chung Sun-Ju , Gould Andrew , Hwang Kyu-Ha , Kim Doeon , Ryu Yoon-Hyun , Shin In-Gu , Shvartzvald Yossi , Yang Hongjing , Yee Jennifer C. , Cha Sang-Mok , Kim Dong-Jin , Kim Seung-Lee , Lee Dong-Joo , Lee Yongseok , Park Byeong-Gon , Pogge Richard W. , Natusch Tim , Mao Shude , Maoz Dan , Penny Matthew T. , Zhu Wei 
Published: April 2023

Aims. We inspect the four microlensing events KMT-2021-BLG-1968, KMT-2021-BLG-2010, KMT-2022-BLG-0371, and KMT-2022-BLG-1013, for which the light curves exhibit partially covered short-term central anomalies. We conduct detailed analyses of the events with the aim of revealing the nature of the anomalies.
Methods. We tested various models that can explain the anomalies of the individual events, including the binary-lens (2L1S) and binary-source (1L2S) interpretations. Under the 2L1S interpretation, we thoroughly inspected the parameter space to determine the existence of degenerate solutions, and if they existed, we tested whether the degeneracy could be resolved.
Results. We find that the anomalies in KMT-2021-BLG-2010 and KMT-2022-BLG-1013 are uniquely defined by planetary-lens interpretations with planet-to-host mass ratios of q ~ 2.8 × 10−3 and ~1.6 × 10−3, respectively. For KMT-2022-BLG-0371, a planetary solution with a mass ratio q ~ 4 × 10−4 is strongly favored over the other three degenerate 2L1S solutions with different mass ratios based on the χ2 and relative proper motion arguments, and a 1L2S solution is clearly ruled out. For KMT-2021-BLG-1968, on the other hand, we find that the anomaly can be explained either by a planetary or a binary-source interpretation, making it difficult to firmly identify the nature of the anomaly. From the Bayesian analyses of the identified planetary events, we estimate that the masses of the planet and host are (Mp/MJ, Mh/M⊙) = (1.07−0.68+1.15, 0.37−0.23+0.40), (0.26−0.11+0.13, 0.63−0.28+0.32), and (0.31−0.16+0.46, 0.18−0.10+0.28) for KMT-2021-BLG-2010L, KMT-2022-BLG-0371L, and KMT-2022-BLG-1013L, respectively.
Diabetische Ketoazidoseraten bei Manifestation eines Typ-1-Diabetes bei Kindern und Jugendlichen in Sachsen
Authors: Manuwald Ulf , Schoffer Olaf , Rothe Ulrike , Kugler Joachim , Kiess Wieland 
Published: April 2023

ZUSAMMENFASSUNGDer Typ-1-Diabetes tritt meist schon im Kindes- und Jugendalter auf. Durch die irreversible Störung der Insulinproduktion bei einem neu manifestierten Diabetes Typ 1 kann die für den Körper benötigte Energie nicht mehr aus Glukose gewonnen werden, sondern ersatzweise aus Fett. Infolge des Fettabbaues kann es dann zu einer diabetische Ketoazidose kommen.Durch Auswertung des Sächsischen Kinder-Diabetes-Registers konnte eine überproportionale Zunahme an diabetischen Ketoazidosen bei Manifestation gegenüber der ebenfalls, aber nur moderat steigenden Typ-1-Diabetes-Inzidenz verzeichnet werden.Somit ist ein Präventionsprogramm zur Senkung der Ketoazidoseraten bei Manifestation durch Früherkennung eines Typ-1-Diabetes dringend erforderlich.
Neues zur Diabetesepidemiologie
Authors: Manuwald Ulf , Schoffer Olaf , Rothe Ulrike , Kugler Joachim , Kiess Wieland 
Published: April 2023

ZUSAMMENFASSUNGDas Sächsische Kinder-Diabetes-Register wurde 1999 etabliert. Eine Auswertung der Daten bis 2019 zeigte einen kontinuierlichen Anstieg der Inzidenz und deutete darauf hin, dass die Periodenprävalenz sowie die letzten Inzidenzraten des Typ-1-Diabetes bei Kindern und Jugendlichen in Sachsen sich verringert oder ein Plateau erreicht haben könnten. Durch den in den weiteren Jahren (2020/2021) starken Anstieg der Inzidenz und Prävalenz setzte sich dieses sich damals andeutende Plateau bezüglich des Trends der Periodenprävalenz nicht fort.Ob dies im Zusammenhang mit COVID19, eine echte Trendzunahme oder ein Zufallseffekt sein könnte, sollte in zukünftigen Studien unter Einbeziehung möglicher korrelierender Umweltfaktoren untersucht werden.
Effects of a Multicomponent Lipid Emulsion on Brain Volumes in Extremely Low Birth Weight Infants
Authors: Costa Simonetta , Cocca Carmen , D'Apolito Gabriella , De Gisi Antonietta , Fattore Simona , Tataranno Maria L. , Benders Manon , Pastorino Roberta , Colosimo Cesare , Vento Giovanni 
Published: April 2023

Objective During the early weeks of life optimization of nutrition in extremely preterm infants presents a critical opportunity to attenuate the adverse neurological consequences of prematurity and potentially improve neurodevelopmental outcome. We hypothesized that the use of multicomponent lipid emulsion (MLE) in parenteral nutrition (PN) would be related to larger volume of the cerebellum on brain magnetic resonance at term of equivalent age (TEA) in extremely low birth weight (ELBW) infants.
Study Design We analyzed the brain magnetic resonance imaging (MRI) at TEA of a cohort of preterm infants with gestational age ≤28 weeks and/or birth weight <1,000 g randomly assigned in our previous trial to receive an MLE or soybean-based lipid emulsion (SLE). The primary outcome of the study was the cerebellar volume (CeV), valued on MRI acquired at TEA. Secondary outcomes included total brain volume (TBV), supratentorial volume, brainstem volume, and CeV corrected for TBV evaluated on MRI acquired at TEA.
Results MRIs at TEA of 34 infants were then analyzed: 17 in the MLE group and 17 in the SLE group. The postmenstrual age (PMA) at which MRIs were performed were comparable between the two study groups. The CeV as well as the PMA-corrected CeV were significantly higher in the MLE group than in the SLE group. No difference was found among the other brain volumes considered.
Conclusion Our results suggest that the use of MLE in PN could promote CeV growth in ELBW infants, valued with MRI at TEA.
Key Points
Sleep and Life Quality in Frail Elderly – A Narrative Review
Authors: Chagas Janeffer de Melo , Santos Eduardo Henrique Rosa , Ronchi Carlos Fernando , Biagini Angelo Piva 
Published: April 2023

Abstract
Introduction Population aging is a growing reality worldwide, characterized by a rapidly developing event that is not always associated with quality of life. Elderly health stands out, pointing to the need for public health policies that ensure effective and resolutive approaches for this population, and should be applied especially by primary health care, through actions that encourage active aging. The present review aimed to identify whether sleep disorders impact the quality of life in frail elderly.
Methods We proceeded with the selection of keywords that led to the search of articles. The search was defined in the Lilacs, PubMed, and Embase databases, conducted from July to November, 2020.We have found a total of 455 articles, of which 9 were included in the present review.
Results The studies obtained subjective (self-report and questionnaires) and objective (devices and exams) data that characterized frailty, disorders, and sleep quality in the elderly. Some studies have found a relationship between frailty and sleep disorders in women, others in men, and some have identified the existence of a relationship between these factors and the age of the participants who composed the samples.
Conclusion Based in our results, we conclude that disorders and poor sleep quality interfere in the quality of life of frail elderly.
Association of Hypovitaminosis D with Sleep Parameters in Rotating Shift Worker Drivers
Authors: de Menezes-Júnior Luiz Antônio Alves , Fajardo Virgínia Capistrano , Neto Raimundo Marques do Nascimento , de Freitas Sílvia Nascimento , Oliveira Fernando Luiz Pereira , Pimenta Fausto Aloísio Pedrosa , Machado-Coelho George Luiz Lins , Meireles Adriana Lúcia 
Published: April 2023

Abstract
Objective To evaluate the association between sleep parameters and hypovitaminosis D in rotating shift drivers.
Material and Methods We conducted a cross-sectional study on 82 male rotating shift workers (24–57 years old) with at least one cardiovascular risk factor (such as hyperglycemia, dyslipidemia, abdominal obesity, physical inactivity, hypertension, and smoking). Polysomnography was used to evaluate sleep parameters. Logistic regression was used to model the association between hypovitaminosis D and sleep parameters after adjustment for relevant covariates.
Results Hypovitaminosis D (< 20 ng/mL) was seen in 30.5% of the workers. Shift workers with hypovitaminosis D had lower sleep efficiency (odds ratio [OR]: 3.68; 95% confidence interval [CI]: 1.95–5.53), lower arterial oxygen saturation (OR: 5.35; 95% CI: 3.37–6.12), and increased microarousal index (OR: 3.85; 95% CI: 1.26–5.63) after adjusting.
Conclusion We suggest that hypovitaminosis D is associated with greater sleep disturbances in rotating shift workers.