bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between adoption of eHealth management module and optimal control of HbA1c in diabetes patients
Authors: Huang Junjie , Chan Sze Chai , Ko Samantha , Tong Ellen , Cheung Clement S. K. , Wong Wing Nam , Cheung Ngai Tseung , Wong Martin C. S. 
Published: April 2023

AbstractIn January 2021, the eHealth App was launched in Hong Kong by the Hong Kong government to support the Electronic Health Record Sharing System (eHRSS). A Health Management Module in the eHealth App introduced new functions to record blood pressure, blood sugar, and heart rate, and downloading and sharing records. This study aims to compare the level of glycaemic control between users of the eHealth App and non-users. Type 2 diabetes patients who have joined the eHRSS with existing haemoglobin A1c (HbA1c) level records are recruited. Correlations between predictors and optimal HbA1c control (<7%) are examined using logistic regression analyses. A total of 109,823 participants are included, with 76,356 non-users of eHealth App, 31,723 users of eHealth App, and 1744 users of the eHealth Management Module together with the App. We collect HbA1c values from Jan 2021 to May 2022, and they are 6 months after the use of the App on average. Users of the eHealth Management Module are found to have more optimal HbA1c levels across all subgroups, with the strongest effect observed in younger females (aOR = 1.66, 95% CI = 1.27–2.17). eHealth App usage is also positively associated with optimal HbA1c levels, particularly amongst younger females (aOR = 1.17, 95% CI = 1.08–1.26). Overall, users of eHealth App and eHealth Management Module demonstrate more optimal HbA1c levels when compared with non-users, particularly among younger adults and females. These findings support its potential adoption in diabetes patients. Future studies should examine the impact of eHealth interventions on other clinical targets and diabetes complications.
V modified Ni-based layer hydroxides for the electrocatalytic upgrading of amines to nitriles
Authors: Bai Shaoxiong , Chen Liang , Bai Jingjing , Lv Chenghang , Xu Shoudong , Zhang Ding , Meng Haibin , Guo Chunli , Yang Huimin , Shang Chenjing 
Published: April 2023

A NiV-LDH/NF catalyst was fabricated via a novel and inexpensive protocol, and it exhibited superior catalytic activity, selectivity, and stability for the electrochemical oxidative dehydrogenation reaction of benzylamine.
Design of a novel robust type‐2 fuzzy‐based adaptive backstepping controller optimized with antlion algorithm for buck converter
Authors: Khavari Fatemeh , Ghamari Seyyed Morteza , Abdollahzadeh Mohammd , Mollaee Hasan 
Published: April 2023

AbstractA type‐2 fuzzy logic‐based adaptive backstepping control (T2F‐ABSC) approach is presented for a DC/DC Buck converter. Lyapunov‐based backstepping control (BSC), which can guarantee convergence along with asymptotic stability of the system. Also, the black‐box technique is applied for the proposed system, which does not require an accurate mathematical model resulting in a lower computational burden, easy implementation, and lower dependency on the states of the model. On the other hand, for wider ranges of disturbances, including parametric variations, load uncertainty, supply voltage variation, and noise, this approach shows an unsuitable practical application based on its fixed gain values; therefore, the control parameters need to be optimized again to provide ideal operations. Type‐2 fuzzy structure is adopted here to optimize the gains of the ABSM in challenging conditions. Type‐2 fuzzy (T2F) has higher efficiency and faster dynamics with more adaptability to the system. To enhance the performance of the T2F, antlion optimization (ALO) has been used in this structure. ALO is a modern nature‐inspired algorithm, and it has some advantages over other optimizing algorithms. Furthermore, it has ability to find optimal answers in a shorter time, more accurately in contrast to the other optimization algorithms and is used to tune the membership function parameters of the (T2F) under the diverse search spaces. To depict the strength of the designed work, fuzzy‐PID and backstepping schemes proposed to carry out an analysis with this work.
Das kutane Plattenepithelkarzinom – ein Update
Authors: Burda Birgit , Schultz Erwin S. 
Published: April 2023

Zusammenfassung
Hintergrund Das kutane Plattenepithelkarzinom (PEK) ist nach dem Basalzellkarzinom der zweithäufigste bösartige Hauttumor. In Deutschland wurden 2014 über 50.000 PEK-Neuerkrankungen dokumentiert. Mit Zunahme der durchschnittlichen Lebenserwartung und Komorbiditäten treten mittlerweile auch gehäuft lokal fortgeschrittene Tumore mit Metastasierung auf.
Methode Selektive Literaturrecherche in PubMed und unter Berücksichtigung der deutschen S3-Leitlinien „Aktinische Keratosen und Plattenepithelkarzinom der Haut“ und „Prävention von Hautkrebs“.
Ergebnisse Beim PEK ist der Goldstandard die vollständige Exzision des Primärtumors mittels histopathologischer Kontrolle der Schnittränder. Eine Radiotherapie kann eingesetzt werden, wenn eine vollständige Exzision nicht erreicht werden kann bzw. Inoperabilität besteht. Im Falle eines metastasierten (mPEK) oder lokal fortgeschrittenen (laPEK) PEK, welches nicht kurativ operiert oder bestrahlt werden kann, werden systemische medikamentöse Therapien eingesetzt. Mit der Zulassung des PD1-Antikörpers Cemiplimab steht seit 2019 in der EU eine neue systemische Therapie zur Behandlung des fortgeschrittenen PEK zur Verfügung. Nach bis zu 3 Jahren Follow-up sprechen noch 46% der Patienten mit mPEK und laPEK auf Cemiplimab an, der Medianwert für das Gesamtüberleben und die Ansprechdauer ist in beiden Gruppen noch nicht erreicht. Weitere Antikörper gegen PD1 oder PDL1, Kombinationstherapien sowie die Immuntherapie mit onkolytischen Viren ermöglichen zahlreiche Therapieoptionen und sind aktuell Gegenstand der Forschung.
Schlussfolgerung Mit der Zunahme von fortgeschrittenen Stadien des PEK nimmt die Wichtigkeit des interdisziplinären Tumorboards für den Therapieentscheid immer mehr zu. Die Weiterentwicklung bestehender therapeutischer Konzepte, die Identifikation von gut wirksamen Kombinationstherapien sowie die Entwicklung weiterer verträglicher zielgerichteter Systemtherapien ist eine entscheidende dermatoonkologische Herausforderung der nächsten Jahre.
Screening Results for Diabetic Retinopathy in Germany in a Real-world
Cohort in a Metropolitan Diabetes Care Center
Authors: Mertes Bernardo , Kuniss Nadine , Piorkowski Michael , Mertes Linus Paul , Hammes Hans-Peter 
Published: April 2023

Abstract
Background Retinal screening is mandatory to prevent vision loss and
blindness due to diabetic retinopathy (DR). The aim of the study was to
determine retinopathy screening rates and potential barriers in a German
metropolitan diabetes care center.
Methods Between May and October 2019, 265 patients with diabetes mellitus
(95% type 2 diabetes; age 62±13.2 years; diabetes duration
11.1±8.5 years, HbA1c 7.4±1.0%) were referred to an
ophthalmologist (referral form with order “Fundoscopy in diabetes
mellitus, findings requested,” completed documentation form
“General practitioner’s/diabetologist’s report
to the ophthalmologist” and prepared documentation form
“Ophthalmologist’s report”). A structured interview was
used to assess the level of compliance with the guidelines and to identify
potential barriers to retinopathy screening in a real-world setting, including
the quantification of extra payments.
Results All patients were interviewed at 7.9±2.5 months after the
referral for retinopathy screening had been issued. According to patient
reporting, fundoscopy was performed in 191 (75%) patients.
Ophthalmological reports were obtained from 119/191 (62%)
patients (46% of the entire cohort). 10/119 (8%)
patients had been previously diagnosed with DR and 6/119 (5%)
with new-onset DR. In 158/191 (83%) of patients, the referral
had been accepted by the ophthalmology practice, of which 25,1% made a
co-payment of 36.2±37.6 €.
Discussion Despite a high screening performance in a real-world setting,
complete screening in compliance with German guidelines, including written
reporting, was found in less than half of the cohort. The prevalence and
incidence of DR are high. Even when referred according to the regulations,
one-quarter of patients made a co-payment. Efficient solutions to current
barriers can emerge with mutual time-saving information prior to examination and
feedback about the implementation of findings into treatment.
Der Zusammenhang zwischen onkologischen Therapien und wahrgenommener
Stigmatisierung bei Krebspatienten mit Brust-, Darm-, Lungen-und Prostatakrebs
– Ergebnisse einer registerbasierten Studie
Authors: Hornemann Beate , Haering Charis , Hentschel Leopold , Rentsch Anke , Taubenheim Sabine , Mehnert-Theuerkauf Anja , Esser Peter , Ernst Jochen 
Published: April 2023

Zusammenfassung
Hintergrund Untersuchungen zur Stigmatisierung von Krebspatienten zeigen
eine moderate bzw. hohe Relevanz wahrgenommener Stigmatisierung. Bislang gibt es
keine Studien, in denen Stigmatisierung explizit in Abhängigkeit von der
onkologischen Therapie betrachtet wird. Wir untersuchten in einer großen
Stichprobe die Rolle der onkologischen Therapie für die wahrgenommene
Stigmatisierung.
Methoden Im Rahmen einer registerbasierten bizentrischen Studie wurden
quantitative Daten von 770 Patienten (47,4% Frauen;
88%≥50 Jahre) mit Brust-, Darm-, Lungen- oder Prostatakrebs
ausgewertet. Die Stigmatisierung wurde mit der deutschen Version der Social
Impact Scale erhoben, das validierte Instrument umfasst neben einem Gesamtscore
vier Subskalen. Die Daten wurden mit dem t-Test sowie einer multiplen Regression
mit verschiedenen soziodemografischen und medizinischen Prädiktoren
analysiert.
Ergebnisse Von den 770 Krebspatienten erhielten 367 (47,7%) eine
Chemotherapie, ggf. in Kombination mit anderen Therapien (Operation,
Strahlentherapie). Bei allen Stigmatisierungsskalen zeigten sich signifikante
Mittelwertunterschiede (Effektstärken bis d=0,49) mit
höheren Werten für Patienten mit Chemotherapie. Die multiplen
Regressionsanalysen für die einzelnen Stigmatisierungsskalen
demonstrieren einen über alle fünf Modelle hinweg signifikanten
Einfluss der Variablen Alter (ß≤− 0,266) und
Depressivität (ß≤0,627) sowie (bei vier Modellen) der
Variable Chemotherapie (ß≤0,140) auf die wahrgenommene
Stigmatisierung. Strahlentherapie weist in allen Modellen nur einen schwachen
Einfluss auf und Operation hat keine Relevanz. Die erklärte Varianz
liegt zwischen R2=27% bis 46,5%.
Diskussion und Schlussfolgerung Die Befunde unterstützen die
Annahme eines Zusammenhangs der onkologischen Therapie, insbesondere der
Chemotherapie, auf die wahrgenommene Stigmatisierung von Krebspatienten.
Wichtige Prädiktoren sind dabei Depressivität und
jüngeres Alter (< 50). Diese (vulnerablen)
Personengruppen sollten in der klinischen Praxis daher besondere Aufmerksamkeit
bzw. psychoonkologische Zuwendung erfahren. Weitere Forschungen zu Verlauf und
Wirkmechanismen der therapiebezogenen Stigmatisierung sind darüber
hinaus notwendig.
Beta-Blocker Use during Pregnancy Correlates with Less Aortic Root Dilatation in Patients with Marfan's Syndrome
Authors: Roberts Emma A. , Pistner Andrew , Osobamiro Oyinkansola , Banning Stephanie , Shalhub Sherene , Albright Catherine , Horovitz Ofir , Buber Jonathan 
Published: April 2023

Abstract
Background Pregnant patients with Marfan's syndrome (MFS) are at an increased risk for adverse aortic outcomes. While beta-blockers are used to slow aortic root dilatation in nonpregnant MFS patients, the benefit of such therapy in pregnant MFS patients remains controversial. The purpose of this study was to investigate the effect of beta-blockers on aortic root dilatation during pregnancy in MFS patients.
Methods This was a longitudinal single-center retrospective cohort study of females with MFS who completed a pregnancy between 2004 and 2020. Clinical, fetal, and echocardiographic data were compared in patients on- versus off-beta-blockers during pregnancy.
Results A total of 20 pregnancies completed by 19 patients were evaluated. Beta-blocker therapy was initiated or continued in 13 (65%) of the 20 pregnancies. Pregnancies on-beta-blocker therapy experienced less aortic growth compared with those off-beta-blockers (0.10 [interquartile range, IQR: 0.10–0.20] vs. 0.30 cm [IQR: 0.25–0.35]; p = 0.03). Using univariate linear regression, maximum systolic blood pressures (SBP), increase in SBP, and absence of beta-blocker use in pregnancy were found to be significantly associated with greater increase in aortic diameter during pregnancy. There were no differences in rates of fetal growth restriction between pregnancies on- versus off-beta-blockers.
Conclusion This is the first study that we are aware of to evaluate changes in aortic dimensions in MFS pregnancies stratified by beta-blocker use. Beta-blocker therapy was found to be associated with less aortic root growth during pregnancy in MFS patients.
Synthesis of Ledipasvir through a Late-Stage Cyclopropanation and Fluorination Process
Authors: Sudhakar Gangarajula , Ramu Chennam , Kumaraguru T. , Reddy M. Sridhar , Rode Haridas B. , Ghosh Subhash , Reddy Ch. Raji 
Published: April 2023

AbstractWe have designed and developed an easily accessible advanced intermediate of ledipasvir that allowed late-stage cyclopropanation and difluorination, thereby providing a novel and more efficient process for the preparation of ledipasvir in the longest linear sequence of 8 steps with 20% overall yield.
Protest Event, Political Culture, and Biography: Post-protest Local Activism in Russia
Authors: Erpyleva Svetlana 
Published: April 2023

AbstractA biographical approach in social science is usually applied to study the life courses of a particular group of people or to explain individual action and meaning-making through biographical determinants. This article aims to develop the biographical approach by showing how it can be used to explain changes in political culture resulting from protest events. Using the case of post-protest local activism in Russia as an example, it demonstrates that a focus on activists’ biographies allows researchers to better understand how the nationwide protest event of 2011–12 changed the political culture of local activism. By focusing on biography, researchers can discover a very important feature of a protest event: its ability to make possible the meeting of people with biographical trajectories that would ordinarily take them in different directions. Consequently, events create opportunities for bringing opposite meanings, skills, and schemes of action together, thereby, allowing a cultural change to emerge. The article suggests that the proposed explanatory model develops biographical sociology by giving biography more power, informs the sociology of event, social movement studies, and political culture theories.
How to really quantify the economic value of customer information in corporate databases
Authors: Lamela-Orcasitas Carlos , García-Madariaga Jesús 
Published: April 2023

AbstractThis paper presents a novel solution to evaluate the real impact of information and information technology (IT) in companies as fundamental tools to assess how valuable the company’s customers are. The focus is on the concept of information and knowledge as an asset with intrinsic economic value and a variable to consider in order to achieve effective customer management. It is dual research. On the one hand, it is an exploratory-conceptual type based on a review of the literature and, on the other hand, it is descriptive-quantitative through the application of an empirical case study. The proposed new customer relationship management (CRM) information value model (VICRM) offers significantly different results from other traditional models. Its main advantages include the possibility of carrying out new segmentations of customers and estimations of the company’s value. On the other hand, the model corrects some of the classic problems in customer evaluation models, such as their high dependence on the retention rate or being very regressive in the first years. The results of this research aim to serve any company whose business model is Business to Consumer (B2C) to calculate, in an effective way, the value of a large amount of information companies have about their customers.
Artificial synapse based on carbon quantum dots dispersed in indigo molecular layer for neuromorphic applications
Authors: Mishra Amrita Bharati , Thamankar R. 
Published: April 2023

Conventional computers are limited in their performance due to the physical separation of the memory and processing units. To overcome this, parallel computation using artificial synapses has been thought of as a possible replacement in computing architecture. The development of nanoelectronic devices that can show synaptic functionalities is very important. Here, we report the robust synaptic functionalities of carbon quantum dots embedded in two terminal indigo-based organic synapses. The carbon quantum dots (CQDs) are prepared using an easy-to-do process from commercial jaggery. The CQDs have a size range between 3.5 and 4.5 nm with excellent light emission in the green region. CQD+indigo-based devices show extremely stable memory characteristics, with ON and OFF states differing by more than 10 Mohm. Devices show excellent long-term potentiation and long-term depression characteristics, with both synaptic weight updates following a double exponential behavior. The extent of nonlinearity is explained using the nonlinearity factor. The linear increase in memory is established with repeated learning and forgetting (or potentiation and depression) curves. This study gives a robust way to make an artificial synapse work efficiently at room temperature with excellent memory and synaptic behavior.
Copper and iron metal resistant rhizospheric bacteria boost the plant growth and bacoside A content in Bacopa monnieri under stress conditions
Authors: Kushwaha Ramesh Kumar , Joshi Samyukta Madhav , Bajaj Renuka , Mastan Anthati , Kumar Vinay , Patel Himani , Jayashree S. , Chaudhary Satya Prakash 
Published: April 2023

Bacteria that enhance plant growth and development and are found in the vicinity of roots are referred to as plant growth-promoting rhizobacteria. Some beneficial bacteria help plant tolerance to many hazardous chemical elements. In this context, Cupriavidus basilensis, Novosphingobium humi, Bacillus zanthoxyli, Bacillus sp., Paenibacillus alvei, Ancylobacter aquaticus and Ralstonia syzygii metal-tolerant rhizospheric bacteria were isolated from rhizospheric soil associated with Bacopa monnieri. The beneficial effects of rhizospheric bacteria on B. monnieri plant physiology and biochemical responses were investigated under pot conditions at two levels (100 μM and 500 μM) of CuSO4 or FeCl3. N. humi, A. aquaticus and R. syzygii bacterial strains were associated with significantly increased height and biomass under normal and stress conditions. An assay for indole acetic acid in isolated rhizospheric bacteria found differential secretion except Bacillus zanthoxyli. Bacoside A is a major phytocompound in B. monnieri with medicinal value; maximum induction was observed in the R. syzygii treatment. High concentration of copper and iron salts negatively influenced height, biomass and photosynthetic pigments; however N. humi, A. aquaticus, Bacilllus sp. and R. syzygii beneficial bacterial helped plants under stress conditions. Moreover, a significant enhancement in chlorophyll a and b was noticed in C. basilensis, B. zanthoxyli, Bacilllus sp., P. alvei and R. syzygii treatments, without much influence on carotenoid levels. Therefore, the present study emphasises the importance of isolating plant growth-promoting rhizobacteria for use in bacopa plants exposed to metals such as copper and iron in soil.
Invasional meltdown-under? Toads facilitate cats by removing a naïve top predator
Authors: Doody J. Sean , Rhind David , McHenry Colin M. , Clulow Simon 
Published: April 2023

Context Australia has been a battleground of invasive versus native species for ~200 years. Two of the most impactful invasive species to Australian animal communities are the toxic cane toad (Rhinella marina) and the predatory feral cat (Felis catus). Australia’s native fauna is evolutionarily naïve to both invaders because neither’s taxonomic group is native to the continent. Both invaders have had severe effects on Australian native animal communities including species extinctions, extirpations, and severe population declines, but until now their effects have generally been thought to be independent of one another. Aims We aimed to determine the impacts of invasive cane toads on monitor lizards and feral cats by estimating changes in relative abundance before and after the toad invasion. Methods We studied toad impacts at three sites in the Kimberley region of northern Australia. We used two methods for estimating relative abundance: camera traps and track station data. Data included greater than 4000 trap days and included 7 years over an 11-year period. Key results As expected, invading cane toads rapidly decimated populations of two species of monitor lizards (97–99% declines), including the top-order predatory Varanus panoptes. Unexpectedly, this loss was associated with a >10-fold mean increase in detection rates of cats by 5 years after the loss of V. panoptes, reflecting relative increases of 3.3–8.7 individual cats per site. Conclusions Although some unknown factor may have caused an increase in cats, their similar trophic position and niche to V. panoptes suggests that toads facilitated cats by effectively removing the lizards from the animal community. This interaction likely reflects one type of invasional meltdown, whereby a non-native species (cane toad) facilitated any aspect of another’s (feral cat) invasion (e.g. survival, reproduction, resource acquisition), but the latter has no detected influence on the former (+/0 interaction). Implications Because both invaders cause declines in animal populations and are difficult to control, the potentially synergistic tandem of cane toads and feral cats could have chronic, irreversible effects on animal communities.
General effective field theory of teleparallel gravity
Authors: Mylova Maria , Said Jackson Levi , Saridakis Emmanuel N 
Published: April 2023

AbstractWe construct the effective field theory (EFT) of the teleparallel equivalent of general relativity (TEGR). Firstly, we present the necessary field redefinitions of the scalar field and the tetrads. Then we provide all the terms at next-to-leading-order, containing the torsion tensor and its derivatives, and derivatives of the scalar field, accompanied by generic scalar-field-dependent couplings, where all operators are suppressed by a scale Λ. Removing all redundant terms using the field redefinitions we result to the EFT of TEGR, which includes significantly more terms comparing to the EFT of general relativity (GR). Finally, we present an application in a cosmological framework. Interestingly enough, although GR and TEGR are completely equivalent at the level of classical equations, we find that their corresponding EFTs possess minor but non-zero differences. Hence, we do verify that at higher energies the excitation and the features of the extra degrees of freedom are slightly different in the two theories, thus making them theoretically distinguishable. Nevertheless, we mention that these differences are suppressed by the heavy mass scale Λ and thus it is not guaranteed that they could be measured in future experiments and observations.