bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Active and Stable NiCuMo Electrocatalyst Supported on 304 Stainless Steel Porous Transport Layer for Hydrogen Evolution in Alkaline Water Electrolyzer
Authors: Zaffora Andrea , Di Franco Francesco , Pupillo Davide , Seminara Barbara , Tranchida Giada , Santamaria Monica 
Published: February 2023

AbstractSeveral functionalized porous transport layers with Pt‐free electrocatalysts for hydrogen evolution reaction in alkaline conditions, based on Ni, Cu, and Mo, are prepared through electrodeposition onto a 304 stainless steel mesh. Morphological characterization confirms the fabrication of electrodes with high electrochemical surface active area due to the formation of hierarchical nanostructures. Mo presence into the electrocatalysts increases the activity toward the hydrogen evolution reaction. The optimization of electrodeposition process leads to the preparation of highly active NiCuMo electrocatalyst that exhibits near zero onset overpotential and overpotentials of 15 and 113 mV at 10 and 100 mA cm−2, respectively, in 1 m KOH electrolyte. Moreover, this electrocatalyst shows superior stability with respect to other Pt‐free electrocatalysts, reaching 100 h of durability with low overpotentials value demonstrating the successful preparation of very promising functionalized porous transport layers for future‐generation alkaline electrolyzers.
Three‐Dimensional Humanized Model of the Periodontal Gingival Pocket to Study Oral Microbiome
Authors: Adelfio Miryam , Martin‐Moldes Zaira , Erndt‐Marino Joshua , Tozzi Lorenzo , Duncan Margaret J. , Hasturk Hatice , Kaplan David L. , Ghezzi Chiara E. 
Published: February 2023

AbstractThe oral cavity contains distinct microenvironments that serve as oral barriers, such as the non‐shedding surface of the teeth (e.g., enamel), the epithelial mucosa and gingival tissue (attached gingiva) where microbial communities coexist. The interactions and balances between these communities are responsible for oral tissue homeostasis or dysbiosis, that ultimately dictate health or disease. Disruption of this equilibrium can lead to chronic inflammation and permanent tissue damage in the case of chronic periodontitis. There are currently no experimental tissue models able to mimic the structural, physical, and metabolic conditions present in the human oral gingival tissue to support the long‐term investigation of host–pathogens imbalances. Herein, the authors report an in vitro 3D anatomical gingival tissue model, fabricated from silk biopolymer by casting a replica mold of an adult human mandibular gingiva to recreate a tooth‐gum unit. The model is based on human primary cultures that recapitulate physiological tissue organization, as well as a native oxygen gradient within the gingival pocket to support human subgingival plaque microbiome with a physiologically relevant level of microbial diversity up to 24 h. The modulation of inflammatory markers in the presence of oral microbiome indicates the humanized functional response of this model and establishes a new set of tools to investigate host–pathogen imbalances in gingivitis and periodontal diseases.
Amorphous K‐Buserite Microspheres for High‐Performance Aqueous Zn‐Ion Batteries and Hybrid Supercapacitors
Authors: Wang Zhi‐Qiang , Chen Hong‐Ming , Liu Xiao‐Dong , Song Li‐Ying , Zhang Bu‐Sheng , Yang Yun‐Guo , Zhang Zhao‐Cheng , Li Qian , Gao Tian‐Qi , Bai Jing , Lau Woon‐Ming , Zhou Dan 
Published: February 2023

AbstractAqueous Zn‐ion batteries (AZIBs) and Zn‐ion hybrid supercapacitors (AZHSCs) are considered promising energy‐storage alternatives to Li‐ion batteries due to the attractive merits of low‐price and high‐safety. However, the lack of suitable cathode materials always hinders their large‐scale application. Herein, amorphous K‐buserite microspheres (denoted as K‐MnOx) are reported as cathode materials for both AZIBs and AZHSCs, and the energy‐storage mechanism is systematically revealed. It is found that K‐MnOx is composed of rich amorphous K‐buserite units, which can irreversibly be transformed into amorphous Zn‐buserite units in the first discharge cycle. Innovatively, the transformed Zn‐buserite acts as active materials in the following cycles and is highly active/stable for fast Zn‐diffusion and superhigh pseudocapacitance, enabling the achievement of high‐efficiency energy storage. In the AZIBs, K‐MnOx delivers 306 mAh g−1 after 100 cycles at 0.1 A g−1 with 102% capacity retention, while in the AZHSCs, it shows 515.0/116.0 F g−1 at 0.15/20.0 A g−1 with 92.9% capacitance retention at 5.0 A g−1 after 20 000 cycles. Besides, the power/energy density of AZHSCs device can reach up to 16.94 kW kg−1 (at 20 A g−1)/206.7 Wh kg−1 (at 0.15 A g−1). This work may provide some references for designing next‐generation aqueous energy‐storage devices with high energy/power density.
Synthesis of Linear Black Gold Nanostructures Processable as Sunlight and Low‐Energy Light Collecting Films for Photo‐Thermoelectricity
Authors: Kim Jeong Han , Pyun Seung Beom , Choi Min Ju , Yeon Ji Won , Hwang Young Ji , Cho Eun Chul 
Published: February 2023

AbstractAs one of the effort to cope with the energy crisis and carbon neutrality, utilization of low‐grade energy generated indoors (e.g., light) is imperative because this saves building and house energy, which accounts for ≈40% of total energy consumption. Although photovoltaic devices could contribute to energy savings, it is also necessary to harvest heat from indoor lights to generate electricity because the light absorbed by materials is mostly transformed into heat. For daily life uses, materials should not only have high absorptance and low emittance but also be easily processed into various forms. To this end, this work synthesizes black aqueous suspensions containing winding and bent linear gold nanostructures with diameters of 3–5 nm and length‐to‐diameter ratios of ≈4–10. Their optical and photo‐thermal characteristics are understood through experimental and theoretical investigations. Black gold nanostructures are conveniently processed into metal‐dielectric films on metal, glass, and flexible substrates. The film on copper has an absorptance of 0.97 and an emittance of 0.08. Under simulated sunlight and indoor LED light illumination, the film has equivalent photo‐thermal and photo‐thermoelectric performances to a top‐tier sunlight‐collecting film. This work attempts to modify the film structure to generate more usable electricity from low‐energy indoor light.
Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity
Authors: Wu Mengge , Yao Kuanming , Huang Ningge , Li Hu , Zhou Jingkun , Shi Rui , Li Jiyu , Huang Xingcan , Li Jian , Jia Huiling , Gao Zhan , Wong Tsz Hung , Li Dengfeng , Hou Sihui , Liu Yiming , Zhang Shiming , Song Enming , Yu Junsheng , Yu Xinge 
Published: February 2023

AbstractA critical challenge lies in the development of the next‐generation neural interface, in mechanically tissue‐compatible fashion, that offer accurate, transient recording electrophysiological (EP) information and autonomous degradation after stable operation. Here, an ultrathin, lightweight, soft and multichannel neural interface is presented based on organic‐electrochemical‐transistor‐(OECT)‐based network, with capabilities of continuous high‐fidelity mapping of neural signals and biosafety active degrading after performing functions. Such platform yields a high spatiotemporal resolution of 1.42 ms and 20 µm, with signal‐to‐noise ratio up to ≈37 dB. The implantable OECT arrays can well establish stable functional neural interfaces, designed as fully biodegradable electronic platforms in vivo. Demonstrated applications of such OECT implants include real‐time monitoring of electrical activities from the cortical surface of rats under various conditions (e.g., narcosis, epileptic seizure, and electric stimuli) and electrocorticography mapping from 100 channels. This technology offers general applicability in neural interfaces, with great potential utility in treatment/diagnosis of neurological disorders.
Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus
Authors: Čarna Maria , Onyango Isaac G. , Katina Stanislav , Holub Dušan , Novotny Jan Sebastian , Nezvedova Marketa , Jha Durga , Nedelska Zuzana , Lacovich Valentina , Vyvere Thijs Vande , Houbrechts Ruben , Garcia‐Mansfield Krystine , Sharma Ritin , David‐Dirgo Victoria , Vyhnalek Martin , Texlova Kateřina , Chaves Hernan , Bakkar Nadine , Pertierra Lucia , Vinkler Mojmir , Markova Hana , Laczo Jan , Sheardova Kateřina , Hortova‐Kohoutkova Marcela , Frič Jan , Forte Giancarlo , Kaňovsky Petr , Belaškova Silvie , Damborsky Jiři , Hort Jakub , Seyfried Nicholas T. , Bowser Robert , Sevlever Gustavo , Rissman Robert A. , Smith Richard A. , Hajduch Marian , Pirrotte Patrick , Spacil Zdenek , Dammer Eric B. , Limbäck‐Stokin Clara , Stokin Gorazd B. 
Published: February 2023

AbstractThe choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in aging and Alzheimer's disease (AD) shows extensive proteomic alterations including evidence of inflammation. Considering inflammation hampers functions of the involved tissues, the CSF abnormalities reported in these conditions are suggestive of ChP injury. Indeed, several studies document ChP damage in aging and AD, which nevertheless remains to be systematically characterized. We here report that the changes elicited in the CSF by AD are consistent with a perturbed aging process and accompanied by aberrant accumulation of inflammatory signals and metabolically active proteins in the ChP. Magnetic resonance imaging (MRI) imaging shows that these molecular aberrancies correspond to significant remodeling of ChP in AD, which correlates with aging and cognitive decline. Collectively, our preliminary post‐mortem and in vivo findings reveal a repertoire of ChP pathologies indicative of its dysfunction and involvement in the pathogenesis of AD.Highlights
Cerebrospinal fluid changes associated with aging are perturbed in Alzheimer's disease
Paradoxically, in Alzheimer's disease, the choroid plexus exhibits increased cytokine levels without evidence of inflammatory activation or infiltrates
In Alzheimer's disease, increased choroid plexus volumes correlate with age and cognitive performance
Divergent Asymmetric Total Synthesis of (−)‐Voacafricines A and B
Authors: Andres Rémi , Wang Qian , Zhu Jieping 
Published: February 2023

AbstractA divergent asymmetric total synthesis of voacafricines A and B, hexacyclic monoterpene indole alkaloids, has been accomplished featuring the following key steps: a) a catalyst‐controlled asymmetric Pictet–Spengler reaction of 6‐methoxytryptamine with a chiral α‐ketoester affording a 1,1‐disubstituted tetrahydro‐β‐carboline in excellent yield and diastereoselectivity; b) oxidative cleavage of a 3,5‐disubstituted cyclopentene furnishing a dialdehyde intermediate, which was effectively differentiated through spontaneous cyclization with the neighboring hydroxy and secondary amine functions; c) intramolecular nucleophilic addition of a tertiary amino nitrogen atom to the in situ generated oxonium species generating stereoselectively an unprecedented 8‐alkyl octahydro‐2H‐5,8‐methanofuro[2,3‐b]azepin‐8‐ium motif bearing five contiguous stereocenters. The synthesis confirmed the absolute configuration of these two natural products.
GTN057, a komaroviquinone derivative, induced myeloma cells' death in vivo and inhibited c‐MET tyrosine kinase
Authors: Okayama Mikio , Fujimori Kota , Sato Mariko , Samata Koichi , Kurita Koki , Sugiyama Hiromu , Suto Yutaka , Iwasaki Genji , Yamada Taketo , Kiuchi Fumiyuki , Ichikawa Daiju , Matsushita Maiko , Hirao Maki , Kunieda Hisako , Yamazaki Kohei , Hattori Yutaka 
Published: February 2023

AbstractObjectiveDespite the development of newly developed drugs, most multiple myeloma (MM) patients with high‐risk cytogenetic abnormalities such as t(4;14) or del17p relapse at anin early stage of their clinical course. We previously reported that a natural product,komaroviquinone (KQN), isolated from the perennial semi‐shrub Dracocephalum komarovi, i.e., komaroviquinone (KQN) and its derivative GTN024 induced the apoptosis of MM cells by producing reactive oxygen species (ROS), but both exhibited significant hematological toxicity. Aim of this study is to clarify anti‐tumor activity, safety and pharmacokinetics of GTN057, an optimization compound of KQN in vivo.MethodsICR/SCID xenograft model of KMS11, a t(4;14) translocation‐positive MM cell line, was used for in vivo study. Mice pharmacokinetics of GTN057 and the degradation products were analyzed by LC‐MS/MS.ResultsHerein, our in vitro experiments revealed that GTN057 is much less toxic to normal hematopoietic cells, induced the apoptosis of both MM cell lines andpatient samples, including those with high‐risk cytogenetic changes. A xenograft model of a high‐risk MM cell line demonstrated that GTN057 significantly delayed the tumor growth with no apparent hematological or systemic toxicities in vivo. The pathological examination of GTN057‐treated tumors in vivoshowed revealed apoptosis of MM cells and anti‐angiogenesis. In addition to the production of ROS, GTN057 inhibited the downstream signaling of c‐MET, a receptor tyrosine kinase a receptor forand hepatocyte growth factor (HGF) receptor. Thus, GTN057 is less toxic and is able tomay be a candidate drug for treating MM patients, via multifunctional mechanisms. We have also extensively studied the pharmacologyical analysis of GTN057. The metabolites of GTN057, (e.g.,such as GTN054), may also have anti‐tumorantitumor activity.ConclusionNatural products or and their derivatives can could be good sources of antineoplastic drugs even for high‐risk cancer.
Hovenianin A Alleviates Hepatic Fibrosis by Inhibiting the PI3K/AKT Pathway in TGF‐β1‐Induced HSCs Based on Network Pharmacology and Transcriptomic Analysis
Authors: Kuang Xiaolan , Ma Ting , Cai Wanna , Yang Jianzhan , Sun Biao , Zhang Xiaoqi , Liu Bo , Wang Sumei , Xu Fangfang 
Published: February 2023

AbstractHepatic fibrosis is a global health problem, which currently has no FDA approved antifibrotic therapy yet. This study aimed to explore the mechanism of Hovenia genus in the treatment of hepatic fibrosis by an integrative strategy combining network pharmacology analysis, molecular docking, transcriptomics and experimental validation. The traditional Chinese medicine systems pharmacology (TCMSP) database and literatures were used to collect the components of Hovenia genus. Public databases including GeneCards, TTD, PharmGkb were used to acquire the putative targets. The GO and KEGG analysis were applied to explore the underlying mechanisms. Furthermore, The TGF‐β1 induced hepatic stellate cells (HSCs) model were performed to evaluate the anti‐hepatic fibrosis activity of Hovenia genus. The RT‐qPCR, Western blotting and flow cytometry experiments were used to validate the anti‐hepatic fibrosis mechanisms of Hovenianin A. The KEGG analysis of network pharmacology and transcriptomics revealed that the core targets mainly enriched in PI3K‐Akt signaling pathways. The cell screening results indicated flavonoids were the main active ingredients of Hovenia. Hovenianin A, a bioactive bisflavonol, was validated to promote the apoptosis of HSCs by inhibiting PI3K‐Akt pathway. Molecular docking further corroborated the binding sites between Hovenianin A and AKT1. In summary, Hovenia may have therapeutic effects on liver fibrosis by modulating the PI3K‐Akt apoptosis pathway. Our findings may facilitate the development of Hovenia genus, which could help to treat liver fibrosis in the future.
Spontaneous splenic pseudocyst: Case report of a rare entity
Authors: Tiwari Govinda Prasad , Poudel Ramchandra , Nepal Sabin , Dhakal Sushil 
Published: February 2023

AbstractSplenic cysts are classified on the basis of epithelial lining, either primary or secondary. Primary cysts are further divided as parasitic and nonparasitic. The secondary cysts are usually post traumatic or after a splenic extension of pancreatic pseudocyst. However, not all pseudocysts are associated with trauma. Mostly, they are asymptomatic (30%–60%) and usually grow in size to cause compressive symptoms. Splenic pseudocysts should be differentiated with other malignant and nonmalignant pathology, specifically hydatid cysts, in order to manage them correctly. The walls of pseudocysts may be degenerative or calcified, which may resemble hydatid cysts. Here, we present a case of a non‐traumatic splenic cyst masquerading as a hydatid cyst preoperatively. The patient was taken up for surgery and intraoperatively noted to be a hemorrhagic cyst with a non‐splenic cyst wall. We decided to preserve the spleen with marsupialisation of cyst and omentoplasty. On histopathology, the diagnosis of a pseudocyst of spleen was made in view of absent epithelial lining. We would like to report this case because of the diagnostic dilemma, its clinical rarity and, even more, in the absence of any history of trauma.
Progress and perspective of single‐atom catalysts for membrane electrode assembly of fuel cells
Authors: Song Zhongxin , Li Junjie , Zhang Qianling , Li Yongliang , Ren Xiangzhong , Zhang Lei , Sun Xueliang 
Published: February 2023

AbstractA fuel cell is an energy conversion device that can continuously input fuel and oxidant into the device through an electrochemical reaction to release electrical energy. Although noble metals show good activity in fuel cell‐related electrochemical reactions, their ever‐increasing price considerably hinders their industrial application. Improvement of atom utilization efficiency is considered one of the most effective strategies to improve the mass activity of catalysts, and this allows for the use of fewer catalysts, saving greatly on the cost. Thus, single‐atom catalysts (SACs) with an atom utilization efficiency of 100% have been widely developed, which show remarkable performance in fuel cells. In this review, we will describe recent progress on the development of SACs for membrane electrode assembly of fuel cell applications. First, we will introduce several effective routes for the synthesis of SACs. The reaction mechanism of the involved reactions will also be introduced as it is highly determinant of the final activity. Then, we will systematically summarize the application of Pt group metal (PGM) and nonprecious group metal (non‐PGM) catalysts in membrane electrode assembly of fuel cells. This review will offer numerous experiences for developing potential industrialized fuel cell catalysts in the future.
Fast capture and stabilization of Li‐ions via physicochemical dual effects for an ultra‐stable self‐supporting Li metal anode
Authors: Zhang Xuzi , Li Yue , Zhang Hao , Li Ge 
Published: February 2023

AbstractLithium (Li) metal is regarded as one of the most promising anode candidates for next‐generation batteries due to its extremely high specific capacity and low redox potential. However, its application is still hindered by the uncontrolled growth of dendritic Li and huge volume fluctuation during cycles. To address these issues, flexible and self‐supporting three‐dimensional (3D) interlaced N‐doped carbon nanofibers (NCNFs) coated with uniformly distributed 2D ultrathin NiCo2S4 nanosheets (denoted CNCS) were designed to eliminate the intrinsic hotspots for Li deposition. Physicochemical dual effects of CNCS arise from limited surface Li diffusivity with a higher Li affinity, leading to uniform Li nucleation and less random accumulation of Li, as confirmed by ab initio molecular dynamics simulations. Due to the unique structure, exchange current density is reduced significantly and metallic Li is further contained within the interspace between the NCNF and NiCo2S4 nanosheets, preventing the formation of dendritic Li. The symmetric cell with a Li/CNCS composite anode shows a long‐running lifespan for almost 1200 h, with an exceptionally low and stable overpotential under 1 mA cm−2/1 mAh cm−2. A full cell coupled with a LiFePO4 cathode at a low N/P ratio of 2.45 shows typical voltage profiles but more significantly enhanced performance than that of a LiFePO4 cathode coupled with a bare Li anode.
Kinase Degraders, Activators, and Inhibitors: Highlights and Synthesis Routes to the Chemical Probes on opnMe.com, Part 1
Authors: Gollner Andreas , Heine Claudia , Hofbauer Karin S. 
Published: February 2023

AbstractKinases are among the most important and successful drug targets. Chemical probe compounds have played a critical role in elucidating the role of kinases in many biological pathways. There are currently twelve well‐validated chemical probes that target kinases available free‐of‐cost via the Molecules to Order (M2O) arm of Boehringer Ingelheim's open innovation platform, opnMe.com. Here we present a summary of the key data for each of these probe compounds and the synthesis routes to all twelve compounds. We hope this will aid researchers who use or plan to use these compounds in their research.
Thermal comfort and energy performance improvement by optimization of shading devices using improved Battle Royal algorithm
Authors: Hu Guiqiu , Hu Xiji , Pouramini Somayeh 
Published: February 2023

SummaryChina's building energy consumption accounts for 27.5% of China's total energy demand. This amount is increasing because of the considerable increase in the rate of household equipment mostly in air‐conditioning systems. In this study, the TRNSYS simulation tool and improved Battle Royal optimizer (IBRO) is coupled for energy optimization of the building based on the simulation to study the impact of the overhangs optimization. The thermal comfort enhancement is evaluated in three case studies of three different weather conditions in China. To validate the achieved results, a comparison of the optimum values with benchmark cases is performed with consideration of heating and cooling demands, and yearly discomfort percentage. According to the achievements, an improvement can be seen in the comfort level. Also, the cooling demand is decreased by 4.2% for Shanghai.
Chemoenzymatic Cascade Reaction for the Valorization of the Lignin Depolymerization Product G−C2‐Dioxolane Phenol
Authors: Terholsen Henrik , Meyer Jule R. H. , Zhang Zhenlei , Deuss Peter J. , Bornscheuer Uwe T. 
Published: February 2023

AbstractCombining solid acid catalysts with enzyme reactions in aqueous environments is challenging because either very acidic conditions inactivate the enzymes, or the solid acid catalyst is neutralized. In this study, Amberlyst‐15 encapsulated in polydimethylsiloxane (Amb‐15@PDMS) is used to deprotect the lignin depolymerization product G−C2 dioxolane phenol in a buffered system at pH 6.0. This reaction is directly coupled with the biocatalytic reduction of the released homovanillin to homovanillyl alcohol by recombinant horse liver alcohol dehydrogenase, which is subsequently acylated by the promiscuous acyltransferase/hydrolase PestE_I208A_L209F_N288A in a one‐pot system. The deprotection catalyzed with Amb‐15@PDMS attains up to 97 % conversion. Overall, this cascade enables conversions of up to 57 %.