bluuebunny/crossref_metadata_2025_split huggingface dataset:
Re-considering Nonresolution in Cyprus: The Impact of Illiberal Conditions on Liberal Peacebuilding
Authors: Gür Gül M. 
Published: April 2023

Abstract
Although bi-communal violence in Cyprus ended almost 50 years ago, the island’s northern and southern sides have yet to reach a comprehensive peace deal. As a result, Cypriots live in a state of functional coexistence whereby they interact with each other in a limited fashion and nonviolently. This article examines the most common explanations for the status quo of nonresolution that has existed in Cyprus for decades before offering a new explanation to consider and address this nonresolution: the mismatch between “liberal” peacebuilding interventions and “illiberal” conditions. To overcome this mismatch, this article argues that it is first necessary to address illiberal conditions to allow peacebuilding attempts to be successful. If illiberalities are not dealt with, they will not only sustain and perpetuate nonresolution, but they will also prevent the emergence of positive peace.
Metal Quivers from Hasanlu
Authors: Cifarelli Megan , Castelluccia Manuel 
Published: April 2023

Abstract
During the remarkable excavations at Hasanlu, in northwestern Iran, thousands of metal objects were discovered, but few have been systematically studied. The goal of this study is to present a catalogue of the metal quivers found by the Joint Expedition to Hasanlu (1956–1977), led by Robert H. Dyson of the University of Pennsylvania Museum. After a brief introduction concerning the site and the evidence for metal quivers in the Ancient Near East as a whole, the examples discovered at Hasanlu will be presented and analyzed within their archaeological contexts.
The Demonic ‘Sub-Humanity’ of the Bears in the Mazdean Framework and Other Remarks
Authors: Panaino Antonio 
Published: April 2023

Abstract
Ancient Iranians knew well “bears”, in spite of the fact that they are not frequently mentioned in the oldest literature of the Zoroastrians. Despite the classification of bears as wild and demonic beasts, their common name was not particularly affected by strong and unexpected changes due to linguistic taboos, at least in the earlier phases. The present article investigates the position of bears within the Pahlavi literature and discusses some aspects of their denomination within the Iranian linguistic area with special care for the Mazdean traditions in which bears were considered as having descended from the civilizing hero J̌am and a demoness.
On Peace Activists and Skilled Survivors
Authors: Mielke Katja 
Published: April 2023

Abstract
This article examines multiple entanglements of Afghan exiles’ biographies in West Germany with Cold War- and contemporary history. The life stories of six men who have been residing in Germany since the 1970s but were physically and cognitively highly mobile in their engagement for change in Afghanistan highlight the role of human agency in transnational history-making. The analysis shows that during the time of intense engagement connecting West Germany and Afghanistan, their lives became truly transnational, and the vernacular cosmopolitanism they practised has shaped transnational history from below. While all six life stories mirror transgressive biographies in connection with wartime events and differ from the global cosmopolitanism of elites, these life courses are neither standardised nor linear. The findings point to three types of transgressive biographies—skilled survivors, quietists and masters of crossover—that have preserved the transnational dimension that had been so significant earlier in the exiles’ lives to varying degrees and differed regarding related perceptions of failure, loss and regret.
Armenian Studies in Conversation with Critical Indigenous Studies and Settler Colonial Studies
Authors: Makhdoumian Helen 
Published: April 2023

Abstract
This article argues that Armenian Studies can learn from and contribute to the fields of critical Indigenous studies and settler colonial studies in generative ways, especially as those fields increasingly become global in scope. After surveying recent scholarly discourses in Armenian Studies, I illuminate pathways forward for interdisciplinary approaches to the study of indigeneity, colonization, genocide, removal, dispossession, biocultural assimilation, cultural heritage preservation, and memory work. I situate these potential possibilities and needed nuances within a larger discussion on the origins, aims, and current state of critical Indigenous studies and settler colonial studies, two interrelated but distinct modes of inquiry.
Use of Tenecteplase in Acute Ischemic Stroke in the Time of SARS-CoV-2
Authors: Ostos Fernando , Rodríguez-López Alberto , Martin Jiménez Paloma , Sánchez Carmen Sánchez , Martínez-Salio Antonio , Ballenilla Federico , Lizasoaín Ignacio , Calleja-Castaño Patricia 
Published: April 2023

Tenecteplase (TNK) is a fibrinolytic drug that is administrated in a single bolus, recommended in eligible patients with acute ischemic stroke prior to mechanical thrombectomy. This study explores its usefulness in adverse situations, such as the SARS-CoV-2 pandemic. We conducted a retrospective study involving consecutive patients with suspected acute ischemic stroke treated either with intravenous fibrinolysis with alteplase during 2019 or with TNK (.25 mg/kg) between March 2020 and February 2021. A comparative analysis was made to compare patient treatment times and prognosis. A total of 117 patients treated with alteplase and 92 with TNK were included. No significant differences were observed in age, main vascular risk factors or previous treatments. The median National Institutes of Health Stroke Scale was 8 in the alteplase group and 10 in those treated with TNK (P = .13). Combined treatment with mechanical thrombectomy was performed in 47% in the alteplase group and 46.7% in the TNK group; Thrombolysis In Cerebral Infarction scale 2b-3 recanalization was achieved in 83% and 90.7%, respectively (P = .30). There was a decrease in onset-to-needle median time (165 min vs 140 min, P < .01) and no significant variations in door-needle median time. There was no significant difference in the incidence of symptomatic hemorrhagic transformation in mortality or functional independence at 3 months. The easier administration of TNK has improved the accessibility of fibrinolytic therapy, even in adverse circumstances, such as the COVID-19 pandemic. Its use appears to be safe and effective, even in patients who are not candidates for mechanical thrombectomy.
Trabecular Bone Remodeling After Posterior Lumbar Interbody Fusion: Comparison of Three-Dimensional Porous Tantalum and Titanium-Coated Polyetheretherketone Interbody Cages
Authors: Segi Naoki , Nakashima Hiroaki , Shinjo Ryuichi , Kagami Yujiro , Machino Masaaki , Ito Sadayuki , Ouchida Jun , Morishita Kazuaki , Oishi Ryotaro , Yamauchi Ippei , Imagama Shiro 
Published: April 2023

Study Design Retrospective cohort study Objectives The criteria for determining completion of intervertebral stability after posterior lumbar interbody fusion (PLIF) remain controversial. Several new radiological indicators of bone growth and osteointegration have been established. We compared computed tomography (CT) findings related to osteointegration after PLIF with interbody cages of two different materials and designs. Methods We retrospectively analyzed data from 103 patients who underwent PLIF with three-dimensional porous tantalum (Tn) cages or titanium-coated polyetheretherketone (TiP) cages. CT images obtained 3 months and 1 year after surgery were examined for trabecular bone remodeling (TBR), cancellous condensation (CC), and vertebral endplate cyst (VEC) formation. The incidences of each finding were compared by cage type, and rates of instrument failure and pseudarthrosis were determined. Results Three months postoperatively, 87% of the levels with Tn cages exhibited TBR, whereas 96% of those with TiP cages did not (P < .001). Most levels with Tn cages levels exhibited TBR and no CC 3 months (81%) and 1 year (94%) after surgery. Although 78% of levels with TiP cages exhibited CC and no TBR 3 months after surgery, 59% exhibited both CC and TBR 1 year after surgery. Significantly fewer VECs formed around the Tn cages than around the TiP cages both 3 months (P = .002) and 1 year (P < .001) after surgery. Implant-related problems occurred at levels that exhibited neither TBR nor CC. Conclusions The porous tantalum cage may enable intervertebral stability that is comparable to bony fusion soon after surgery.
Mosunetuzumab monotherapy is active and tolerable in patients with relapsed/refractory diffuse large B-cell lymphoma
Authors: Bartlett Nancy L. , Assouline Sarit , Giri Pratyush , Schuster Stephen J. , Cheah Chan Y. , Matasar Matthew , Gregory Gareth P. , Yoon Dok Hyun , Shadman Mazyar , Fay Keith , Yoon Sung-Soo , Panizo Carlos , Flinn Ian , Johnston Anna , Bosch Francesc , Sehn Laurie H. , Wei Michael C. , Yin Shen , To Iris , Li Chi-Chung , Huang Huang , Kwan Antonia , Penuel Elicia , Budde Lihua E. 
Published: April 2023

Abstract
As part of a phase 1 or 2 study, this single-arm expansion cohort established the efficacy and safety of mosunetuzumab monotherapy in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) (received ≥2 previous lines of therapy). Intravenous mosunetuzumab was administered with cycle (C) 1 step-up dosing for cytokine release syndrome (CRS) mitigation: C1 day (D) 1: 1 mg; C1D8 2 mg; C1D15 and C2D1: 60 mg; C3 + D1: 30 mg. Hospitalization was not mandatory. Patients with complete response (CR) completed treatment after C8; those with partial response or stable disease continued treatment for a total of 17 cycles. The primary end point was CR rate (best response), assessed against a historical control CR rate (20%) by independent review facility. Eighty-eight patients (73.9% de novo DLBCL; 26.1% transformed follicular lymphoma) were enrolled; all had received previous anthracycline and anti-CD20 therapy. Overall response and CR rates were 42.0% (95% confidence interval [CI], 31.6-53.1) and 23.9% (95% CI, 15.4-34.1), respectively; CR rate did not reach statistical significance vs the historical control (P = .36). Median time to first response was 1.4 months. Median progression-free survival was 3.2 months (95% CI, 2.2-5.3). The CR rate in 26 patients who received previous chimeric antigen receptor T-cell (CAR-T) therapy was 12%. CRS was one of the most common adverse events (26.1% of patients); predominantly grade 1 to 2 and primarily in C1. Four patients (4.5%) discontinued mosunetuzumab owing to adverse events. Mosunetuzumab demonstrated notable efficacy and a manageable safety profile in patients with R/R DLBCL, including those previously treated with CAR-Ts. This trial was registered at www.clinicaltrials.gov as #NCT02500407.
Chromatin accessibility differences between alpha, beta, and delta cells identifies common and cell type-specific enhancers
Authors: Mawla Alex M. , van der Meulen Talitha , Huising Mark O. 
Published: April 2023

Abstract
Background
High throughput sequencing has enabled the interrogation of the transcriptomic landscape of glucagon-secreting alpha cells, insulin-secreting beta cells, and somatostatin-secreting delta cells. These approaches have furthered our understanding of expression patterns that define healthy or diseased islet cell types and helped explicate some of the intricacies between major islet cell crosstalk and glucose regulation. All three endocrine cell types derive from a common pancreatic progenitor, yet alpha and beta cells have partially opposing functions, and delta cells modulate and control insulin and glucagon release. While gene expression signatures that define and maintain cellular identity have been widely explored, the underlying epigenetic components are incompletely characterized and understood. However, chromatin accessibility and remodeling is a dynamic attribute that plays a critical role to determine and maintain cellular identity.

Results
Here, we compare and contrast the chromatin landscape between mouse alpha, beta, and delta cells using ATAC-Seq to evaluate the significant differences in chromatin accessibility. The similarities and differences in chromatin accessibility between these related islet endocrine cells help define their fate in support of their distinct functional roles. We identify patterns that suggest that both alpha and delta cells are poised, but repressed, from becoming beta-like. We also identify patterns in differentially enriched chromatin that have transcription factor motifs preferentially associated with different regions of the genome. Finally, we not only confirm and visualize previously discovered common endocrine- and cell specific- enhancer regions across differentially enriched chromatin, but identify novel regions as well. We compiled our chromatin accessibility data in a freely accessible database of common endocrine- and cell specific-enhancer regions that can be navigated with minimal bioinformatics expertise.

Conclusions
Both alpha and delta cells appear poised, but repressed, from becoming beta cells in murine pancreatic islets. These data broadly support earlier findings on the plasticity in identity of non-beta cells under certain circumstances. Furthermore, differential chromatin accessibility shows preferentially enriched distal-intergenic regions in beta cells, when compared to either alpha or delta cells.
Assessment of the nasal microbiota in dogs with fungal rhinitis before and after cure and in dogs with chronic idiopathic rhinitis
Authors: Vangrinsven Emilie , Fastrès Aline , Taminiau Bernard , Billen Frédéric , Daube Georges , Clercx Cécile 
Published: April 2023

Abstract
Background
Pathogenesis of canine fungal rhinitis is still not fully understood. Treatment remains challenging, after cure turbinate destruction may be associated with persistent clinical signs and recurrence of fungal rhinitis can occur. Alterations of the nasal microbiota have been demonstrated in dogs with chronic idiopathic rhinitis and nasal neoplasia, although whether they play a role in the pathogenesis or are a consequence of the disease is still unknown. The objectives of the present study were (1) to describe nasal microbiota alterations associated with fungal rhinitis in dogs, compared with chronic idiopathic rhinitis and controls, (2) to characterize the nasal microbiota modifications associated with successful treatment of fungal rhinitis. Forty dogs diagnosed with fungal rhinitis, 14 dogs with chronic idiopathic rhinitis and 29 healthy control dogs were included. Nine of the fungal rhinitis dogs were resampled after successful treatment with enilconazole infusion.

Results
Only disease status contributed significantly to the variability of the microbiota. The relative abundance of the genus Moraxella was decreased in the fungal rhinitis (5.4 ± 18%) and chronic idiopathic rhinitis (4.6 ± 8.7%) groups compared to controls (51.8 ± 39.7%). Fungal rhinitis and chronic idiopathic rhinitis groups also showed an increased richness and α-diversity at species level compared with controls. Increase in unique families were associated with fungal rhinitis (Staphyloccaceae, Porphyromonadaceae, Enterobacteriaceae and Neisseriaceae) and chronic idiopathic rhinitis (Pasteurellaceae and Lactobacillaceae). In dogs with fungal rhinitis at cure, only 1 dog recovered a high relative abundance of Moraxellaceae.

Conclusions
Results confirm major alterations of the nasal microbiota in dogs affected with fungal rhinitis and chronic idiopathic rhinitis, consisting mainly in a decrease of Moraxella. Besides, a specific dysbiotic profile further differentiated fungal rhinitis from chronic idiopathic rhinitis. In dogs with fungal rhinitis, whether the NM returns to its pre-infection state or progresses toward chronic idiopathic rhinitis or fungal rhinitis recurrence warrants further investigation.
Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose
Authors: Wang Ya , Wang Jiahui , Li Hehai , Lao Jianlong , Jia Dan , Liu Junlong , Wang Jinming , Luo Jianxun , Guan Guiquan , Yin Hong , Li Youquan 
Published: April 2023

Abstract
Background
Probiotics can reduce free radical scavenging rate and oxidative damage, and improve activity of crucial antioxidative enzymes in host cells. This study aimed to isolate Bifidobacterium spp. from faeces of babies, and investigate the antioxidant effects of the Bif. longum T37a in mice weight loss and aging model induced by D-galactose.

Results
T37a have good antioxidant properties in the DPPH assay and anti-lipid peroxidation test. Compared with the model group, T37a low group significantly increased the thymus index and the levels of T-AOC and GSH-Px of mice. T37a high group significantly decreased the spleen and liver index of mice and the levels of MDA in liver, significantly increased in liver HDL-C levels, and decreased LDL-C in liver.

Conclusions
T37a may be an anti-aging and weight-loss probiotics for its antioxidant capacity, and it is necessary to study further the molecular mechanism of T37a as antioxidant.
A new method to separate the impacts of interday and intraday temperature variability on mortality
Authors: Wen Bo , Wu Yao , Guo Yuming , Li Shanshan 
Published: April 2023

Abstract
Background
Temperature variability (TV) is associated with increased mortality risks. However, the independent impacts of interday and intraday are still unknown.

Methods
We proposed a new method to decompose TV into interday TV and intraday TV through algebra derivation. Intraday TV was defined as the weighted average standard deviation (SD) of minimum temperature and maximum temperature on each day. Interday TV was defined as the weighted SD of daily mean temperatures during the exposure period. We then performed an illustrative analysis using data on daily mortality and temperature in France in 2019–2021.

Results
The novel interday and intraday TV indices were good proxies for existing indicators, inlcluding diurnal temperature range (DTR) and temperature change between neighbouring days (TCN). In the illustrative analyses, interday and intraday TVs showed differentiated mortality risks. Mortality burden related to TV was mainly explained by the intraday component, accounting for an attributable fraction (AF) of 1.81% (95% CI: 0.64%, 2.97%) of total mortality, more than twice the AF of interday TV (0.86%, 95% CI: 0.47%, 1.24%).

Conclusions
This study proposed a novel method for identifying and isolating the different components of temperature variability and offered a comprehensive way to investigate their health impacts.
Randomized prospective trial to detect and distinguish between medication nonadherence, drug-drug interactions, and disease progression in chronic cardiometabolic disease
Authors: Peabody John W , Ganesan Divya , Valdenor Czarlota , Paculdo David , Schrecker Joshua , Westerfield Christopher , Heltsley Rebecca 
Published: April 2023

Abstract
Background
Disentangling nonadherence (NA), drug-drug interactions (DDIs), and disease progression from each other is an important clinical challenge for providers caring for patients with cardiometabolic diseases. NAs and DDIs are both ubiquitous and often overlooked. We studied a novel chronic disease management (CDM) test to detect medication adherence and the presence and severity of DDIs.

Materials and methods
We conducted a prospective, randomized controlled trial of 236 primary care physicians using computer-based, simulated patients, measuring clinical care with and without access to the CDM test. The primary outcomes were whether use of the CDM test increased the accuracy of diagnoses and ordering better treatments and how effective the intervention materials were in getting participants to order the CDM test.

Results
Physicians given the CDM test results showed a + 13.2% improvement in their diagnosis and treatment quality-of-care scores (p < 0.001) in the NA patient cases and a + 13.6% improvement in the DDI cases (p < 0.001). The difference-in-difference calculations between the intervention and control groups were + 10.4% for NA and + 10.8% for DDI (p < 0.01 for both). After controlling for physician and practice co-factors, intervention, compared to control, was 50.4x more likely to recognize medication NA and 3.3x more likely to correctly treat it. Intervention was 26.9x more likely to identify the DDI and 15.7x more likely to stop/switch the interacting medication compared to control. We found no significant improvements for the disease progression patient cases.

Conclusion
Distinguishing between nonadherence, drug-drug interactions, and disease progression is greatly improved using a reliable test, like the CDM test; improved diagnostic accuracy and treatment has the potential to improve patient quality of life, medication safety, clinical outcomes, and efficiency of health delivery.

Trial Registration
clinicaltrials.gov (NCT05192590).
Characteristics and outcomes of COVID-19 patients during the BA.5 omicron wave in Tehran, Iran: a prospective observational study
Authors: Salehi Mohammadreza , Salami Khaneshan Arezoo , Farahani Abbas Shakoori , Doomanlou Mahsa , Arabzadeh Mohammad , Sobati Abolfazl , Farhadi Kousha , Fattahi Reza , Mohammadnejad Esmaeil , Abdoli Asghar , Zebardast Jayran 
Published: April 2023

Abstract
Background
Omicron (B.1.1.529) is the fifth variant of concern of SARS-CoV-2, which has several subvariants. Clinical features of BA.1 and BA.2 infections have been described in the literature, but we have limited information about the clinical profile of BA.5, which caused the seventh wave in Iran.

Methods
A prospective observational study was conducted on the BA.5 confirmed patients referred to Imam Khomeini Hospital Complex, Tehran, Iran, from 11th to 31st August 2022. The patients were divided into the two groups of outpatients and hospitalized patients, and their clinical, radiological, and laboratory data and outcomes were recorded and analyzed.

Results
We included 193 patients with confirmed BA.5 infection, of whom 48 patients (24·8%) were hospitalized. The mean age of the patients was 45·3 ± 16·5 years, and 113 patients (58·5%) were female. The mean number of days patients had symptoms was 6·8 ± 2·4 days. The most common symptoms were weakness (69·9%), sore throat (67·4%), myalgia (66·3%), hoarseness (63·7%), headache (55·4%), fatigue (54·9%), and dry cough (50·3%). Fever and dyspnea were significantly more observed in the hospitalized patients (p < 0·0001). The COVID-19 vaccination rate was significantly lower in hospitalized patients than in outpatients (35/48–72·9% vs. 140/145 − 96·6%, p < 0·0001). The most common underlying diseases were hypertension (16·1%), diabetes mellitus (9·8%), and cardiovascular diseases (9·8%), all of which were significantly more common in hospitalized patients. Lung opacities were observed in 81·2% of hospitalized patients. By the end of our study, 1·5% of patients died despite receiving critical care services.

Conclusions
Our findings suggested that BA.5 symptoms are more non-respiratory and usually improve within 7 days. Although the proportion of hospitalized patients is still significant, very few patients require intensive care. COVID-19 vaccination is effective in reducing the hospitalization rate.

Trial registration
Not applicable. This study is not a clinical trial.