bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Do Different Processes Shape Temperature Probability Distributions? A Percentile-Averaged Temperature Tendency Decomposition
Authors: Quan Heng , Zhang Boer , Bourguet Stephen , Linz Marianna , Chen Gang 
Published: April 2023

Abstract
Studying temperature probability distributions and the physical processes that shape them is important for understanding extreme temperature events. Previous work has used a conditional mean temperature framework to reveal whether horizontal temperature advection drives temperature to extreme or median values at a specific location as a method to dynamically interpret temperature probability distributions. In this paper, we generalize this method to study how other processes shape temperature probability distributions and explore the diverse effects of horizontal temperature advection on temperature probability distributions at different locations and different temperature percentiles. We apply this generalized method to several representative regions to demonstrate its use. We find that temperature advection drives temperatures toward more extreme values over most land in the midlatitudes (i.e., cold air advection occurs during cold anomalies and warm air advection occurs during warm anomalies). In contrast, we find that horizontal temperature advection dampens temperature anomalies in some coastal summer monsoon regions, where extreme temperatures result from other processes, such as horizontal humidity advection and vertical temperature advection. By calculating the mean of processes conditioned on the temperature percentile, this method enables composite analysis of processes that contribute to events for all percentiles and a range of processes. We show examples of composites at different percentiles for certain processes and regions to illustrate the conditional mean analysis. This general approach may benefit future studies related to temperature probability distributions and extreme events.
The role of evanescent modes in global-local analysis of ultrasonic guided waves in plates with varying local zone-scatterer relations
Authors: Spada Antonino , Zhang Mingyue , Lanza di Scalea Francesco , Capriotti Margherita 
Published: April 2023

In order to provide a reliable and robust SHM performance, Ultrasonic Guided Waves (UGWs) need to be analyzed and understood. Numerical modeling of UGW propagation and scattering by hybrid methods offers the possibility of simulating UGW interaction with waveguides of arbitrary cross-sections and discontinuities. Maximizing the accuracy of such methods is important to perform quantitative SHM, while maintaining minimum computational cost. This work investigates the role of evanescent modes in the numerical analysis of UGWs in aluminum and composite plates with defects, by the hybrid Global-Local method. The complex solutions to the UGW eigenvalue problem are found and the scattering spectra for A0 and S0 incident modes are calculated. The accuracy of the numerical solution is then studied by computing the error in terms of energy balance. Parametric studies with respect to the local zone size, defect dimensions and shape are conducted including and excluding evanescent modes in the analysis. Considerations are provided to obtain a solution with error no greater than 5%, in terms of varying local zone – scatterer relations within plate waveguides.
New insights in the multimodal imaging of retinitis pigmentosa
Authors: Berni Alessandro , Arrigo Alessandro , Bianco Lorenzo , Antropoli Alessio , Saladino Andrea , Mansour Ahmad M. , Vilela Manuel , Bandello Francesco , Parodi Maurizio Battaglia 
Published: April 2023

Retinitis pigmentosa (RP) is a group of inherited rod-cone dystrophies, noted for a high genotypical and phenotypical heterogeneity. Traditionally, VA, visual field, and electroretinography have been used to assess RP progression. However, visual acuity and visual field tests are essentially subjective and, especially in the late stages of the disease, are unable to confidently reveal minor progression. Therefore, there is a need for novel examination modalities that rely on quantitative, structural measurements. In this regard, several non-invasive imaging techniques have been studied, including spectral-domain optical coherence tomography, optical coherence tomography angiography, and fundus autofluorescence. By correlating surrogate biomarkers with functional measurements of the disease, these techniques may be able to develop reliable outcome meters that can be used to gain a deeper understanding of the underlying causes of the disease and to assess the effectiveness of therapy even before an actual loss of vision occurs. In this review, we will summarize the recent imaging findings and biomarkers that have been identified in RP patients. Our goal is to provide information that can promptly aid in selecting patients for clinical trials and new gene therapies, monitoring the disease progression, and evaluating treatment outcomes.
Experiences with recruitment and retention of adolescents and emerging adults in a weight loss intervention trial
Authors: Horst Gilbert , Miller Hailey , Peeler Anna , Charleston Jeanne , Dell Thomas , Juraschek Stephen P , Brady Tammy M 
Published: April 2023

Background/Aims: Efficient and effective participant recruitment is key for successful clinical research. Adolescent and emerging adult recruitment into clinical trials can be particularly challenging, especially when targeting underrepresented groups. This study aimed to determine the most successful recruitment strategies from those employed during a pediatric trial testing the efficacy of a behavioral intervention on adiposity and cardiovascular disease risk. Methods: We determined the effectiveness, cost, and diversity of the final research population by each recruitment method utilized in the EMPower trial, a randomized clinical trial designed to test the effect of a technology-delivered behavioral Healthy Lifestyle intervention on adiposity, blood pressure, and left ventricular mass among adolescents and emerging adults with overweight or obesity. Effectiveness was determined by respondent yield (RY; number of respondents/number contacted), scheduled yield (SY; number scheduled for a baseline visit/number of respondents), enrollment yield (EY; number enrolled/number of respondents), and retention (number completed/number enrolled). Cost-effectiveness of each recruitment method was calculated and demographics of participants recruited via each method was determined. Results: A minimum of 109,314 adolescents and emerging adults were contacted by at least one recruitment method (clinic, web-based, postal mailing, electronic medical record (EMR) messaging) leading to 429 respondents. The most successful strategies in terms of RY were clinic-based recruitment (n = 47, 61% RY), community web-postings (n = 109, 5.33% RY), and EMR messaging (n = 163, 0.99% RY); however, website, postal mailings, and EMR recruitment led to more successful SY and EY. Postal mailings were the most costly strategy to employ (US$3261/completed participant) with EMR messaging the second most costly (US$69/completed participant). Community web-postings were free of charge. Clinic-based recruitment did not add additional costs, per se, but did require a substantial amount of personnel time (63.6 h/completed participant). Final cohort diversity primarily came from postal mailings (57% Black) and EMR messages (50% female). Conclusion: Electronic medical record messaging and web-based recruitment were highly successful and cost-effective strategies in a pediatric clinical trial targeting adolescents and emerging adults, but was less successful in recruiting a diverse cohort. Clinic recruitment and postal mailings, despite being costly and time-consuming, were the strategies that enrolled a greater proportion of underrepresented groups. While online forms of trial recruitment are growing in popularity, clinic-based recruitment and non-web-based strategies may be required to ensure participant diversity and representation.
E. urophylla × E. grandis high-quality genome and comparative genomics provide insights on evolution and diversification of eucalyptus
Authors: Shen Chao , Li Limei , Ouyang Lejun , Su Min , Guo Kexin 
Published: April 2023

AbstractBackgroundEucalyptus urophylla × Eucalyptus grandis, an economically important forest tree, provides important raw material for energy and reduces damage to native forests. However, the absence of a high-qualityE. urophylla × E. grandisreference genome has significantly hindered its evolution and genetic analysis.ResultsWe successfully presented a high-quality reference genome ofE. urophylla × E. grandis(545.75 Mb; scaffold N50, 51.62 Mb) using a combination of the Illumina, PacBio HiFi, and Hi-C sequencing platforms. A total of 34,502 genes and 58.56% of the repetitive sequences in this genome were annotated. Using genome evolution analyses, we identified a recent whole-genome duplication (WGD) event inE. urophylla × E. grandis. We further found that gene families associated with starch and sucrose metabolism, flavonoid biosynthesis, and plant–pathogen interaction were significantly expanded inE. urophylla × E. grandis. Moreover, comparative genomic and evolutionary analyses showed large structural variations among the different chromosomes of the 34 Eucalyptus accessions, which were divided into six clades.ConclusionsOverall, our findings provide a valuable resource for expanding our understanding of theE. urophylla × E. grandisgenome evolution, genetic improvement, and its comparative biology.
Identification of an individualized therapy prognostic signature for head and neck squamous cell carcinoma
Authors: Lin Cheng , Chen Yuebing , Pan Jianji , Lu Qiongjiao , Ji Pengjie , Lin Shuiqin , Liu Chunfeng , Lin Shaojun , Li Meifang , Zong Jingfeng 
Published: April 2023

Abstract
Background
Head and neck squamous cell carcinoma (HNSCC) are the most common cancers in the head and neck. Therapeutic response-related genes (TRRGs) are closely associated with carcinogenesis and prognosis in HNSCC. However, the clinical value and prognostic significance of TRRGs are still unclear. We aimed to construct a prognostic risk model to predict therapy response and prognosis in TRRGs-defined subgroups of HNSCC.

Methods
The multiomics data and clinical information of HNSCC patients were downloaded from The Cancer Genome Atlas (TCGA). The profile data GSE65858 and GSE67614 chip was downloaded from public functional genomics data Gene Expression Omnibus (GEO). Based on TCGA-HNSC database, patients were divided into a remission group and a non-remission group according to therapy response, and differentially expressed TRRGs between those two groups were screened. Using Cox regression analysis and Least absolute shrinkage and selection operator (LASSO) analysis, candidate TRRGs that can predict the prognosis of HNSCC were identified and used to construct a TRRGs-based signature and a prognostic nomogram.

Result
A total of 1896 differentially expressed TRRGs were screened, including 1530 upregulated genes and 366 downregulated genes. Then, 206 differently expressed TRRGs that was significantly associated with the survival were chosen using univariate Cox regression analysis. Finally, a total of 20 candidate TRRGs genes were identified by LASSO analysis to establish a signature for risk prediction, and the risk score of each patient was calculated. Patients were divided into a high-risk group (Risk-H) and a low-risk group (Risk-L) based on the risk score. Results showed that the Risk-L patients had better overall survival (OS) than Risk-H patients. Receiver operating characteristic (ROC) curve analysis revealed great predictive performance for 1-, 3-, and 5-year OS in TCGA-HNSC and GEO databases. Moreover, for patients treated with post-operative radiotherapy, Risk-L patients had longer OS and lower recurrence than Risk-H patients. The nomogram involves risk score and other clinical factors had good performance in predicting survival probability.

Conclusions
The proposed risk prognostic signature and Nomogram based on TRRGs are novel promising tools for predicting therapy response and overall survival in HNSCC patients.
Selenium uptake, translocation, subcellular distribution and speciation in winter wheat in response to phosphorus application combined with three types of selenium fertilizer
Authors: Hu Caixia , Nie Zhaojun , Shi Huazhong , Peng Hongyu , Li Guangxin , Liu Haiyang , Li Chang , Liu Hongen 
Published: April 2023

Abstract
Background
Selenium (Se) deficiency causes a series of health disorders in humans, and Se concentrations in the edible parts of crops can be improved by altering exogenous Se species. However, the uptake, transport, subcellular distribution and metabolism of selenite, selenate and SeMet (selenomethionine) under the influence of phosphorus (P) has not been well characterized.

Results
The results showed that increasing the P application rate enhanced photosynthesis and then increased the dry matter weight of shoots with selenite and SeMet treatment, and an appropriate amount of P combined with selenite treatment increased the dry matter weight of roots by enhancing root growth. With selenite treatment, increasing the P application rate significantly decreased the concentration and accumulation of Se in roots and shoots. P1 decreased the Se migration coefficient, which could be attributed to the inhibited distribution of Se in the root cell wall, but increased distribution of Se in the root soluble fraction, as well as the promoted proportion of SeMet and MeSeCys (Se-methyl-selenocysteine) in roots. With selenate treatment, P0.1 and P1 significantly increased the Se concentration and distribution in shoots and the Se migration coefficient, which could be attributed to the enhanced proportion of Se (IV) in roots but decreased proportion of SeMet in roots. With SeMet treatment, increasing the P application rate significantly decreased the Se concentration in shoots and roots but increased the proportion of SeCys2 (selenocystine) in roots.

Conclusion
Compared with selenate or SeMet treatment, treatment with an appropriate amount of P combined with selenite could promote plant growth, reduce Se uptake, alter Se subcellular distribution and speciation, and affect Se bioavailability in wheat.
Barotrauma in COVID-19 acute respiratory distress syndrome: retrospective analysis of the COVADIS prospective multicenter observational database
Authors: Serck Nicolas , Piagnerelli Michael , Augy Jean Loup , Annoni Filippo , Ottavy Gregoire , Courcelle Romain , Carbutti Giuseppe , Lejeune Francois , Vinsonneau Christophe , Sauneuf Bertrand , Lefebvre Laurent , Higny Julien , Grimaldi David , Lascarrou Jean-Baptiste 
Published: April 2023

Abstract
Background
Despite evidence suggesting a higher risk of barotrauma during COVID-19-related acute respiratory distress syndrome (ARDS) compared to ARDS due to other causes, data are limited about possible associations with patient characteristics, ventilation strategy, and survival.

Methods
This prospective observational multicenter study included consecutive patients with moderate-to-severe COVID-19 ARDS requiring invasive mechanical ventilation and managed at any of 12 centers in France and Belgium between March and December 2020. The primary objective was to determine whether barotrauma was associated with ICU mortality (censored on day 90), and the secondary objective was to identify factors associated with barotrauma.

Results
Of 586 patients, 48 (8.2%) experienced barotrauma, including 35 with pneumothorax, 23 with pneumomediastinum, 1 with pneumoperitoneum, and 6 with subcutaneous emphysema. Median time from mechanical ventilation initiation to barotrauma detection was 3 [0–17] days. All patients received protective ventilation and nearly half (23/48) were in volume-controlled mode. Barotrauma was associated with higher hospital mortality (P < 0.001) even after adjustment on age, sex, comorbidities, PaO2/FiO2 at intubation, plateau pressure at intubation, and center (P < 0.05). The group with barotrauma had a lower mean body mass index (28.6 ± 5.8 vs. 30.3 ± 5.9, P = 0.03) and a higher proportion of patients given corticosteroids (87.5% vs. 63.4%, P = 0.001).

Conclusion
Barotrauma during mechanical ventilation for COVID-19 ARDS was associated with higher hospital mortality.
Effect of anesthesia administration method on apgar scores of infants born to women undergoing elective cesarean section
Authors: Gwanzura Chipo , Gavi Samuel , Mangiza Marcia , Moyo Faith Vhenekai , Lohman Matthew C. , Nhemachena Taazadza , Chipato Tsungai 
Published: April 2023

Abstract
Background
Neonatal health at delivery as measured by apgar scores is an important outcome. This study was done to assess the impact of anesthesia on Apgar 1-minute and 5-minute scores of infants delivered through elective cesarean section in Zimbabwe.

Methods
We carried out a secondary analysis of data from the Efficacy of Tranexamic Acid in Preventing Postpartum Hemorrhage (ETAPPH) clinical trial in Zimbabwe. Outcomes measured were infant Apgar scores at 1 and 5 min, exposure was the administration of either a general (intravenous propofol/ketamine/sodium thiopental) or spinal (hyperbaric bupivacaine 0.5%) anesthesia for anesthesia during the elective cesarean section procedure. Marginal Structural Logistic Modelling (MSM) using an unstabilized Inverse Probability Treatment Weight (IPTW) estimator was used to assess the relationship between anesthetic administration method and infant Apgar scores.

Results
Four hundred and twenty-one (421) women who had an elective caesarean section in the ETAPPH study had their infants assessed for Apgar scores. Comparing general anesthesia to spinal anesthesia, spinal anesthesia was related to good Apgar scores at 1-minute (adjusted odds ratio [aOR] = 4.0, 95% Confidence Interval = 1.5–10.7, sensitivity analysis E-value = 3.41). Spinal anesthetic administration was also related to good Apgar scores at 5 min (adjusted odds ratio [aOR] = 6.2, 95% Confidence Interval = 1.6–23.1, sensitivity analysis E-value = 4.42).

Conclusions
When providing anesthesia for patients undergoing elective cesarean section, care should be taken on the method of administration of anesthetic agents. General anesthesia tends to depress Apgar scores at 1 min, although most neonates recover and have better scores at 5 min. Spinal anesthesia should be the first choice whenever possible.

Trial registration
The clinical trial from which data of this study was abstracted was registered under clinical trials registration number NCT04733157.
Characteristics, prognostic determinants of monocytes, macrophages and T cells in acute coronary syndrome: protocol for a multicenter, prospective cohort study
Authors: Lin Muzhi , Wang Bing , Wei Bo , Li Chao , Tu Lin , Zhu Xiaohan , Wu Zheyi , Huang Guangwei , Lu Xiyang , Xiong Guobao , Lu Shanglin , Yang Xinglin , Li Peng , Liu Xingde , Li Wei , Lu Yuming , Zhou Haiyan 
Published: April 2023

Abstract
Background
Acute coronary syndrome(ACS) is the leading cause of mortality and disability worldwide. Immune response has been confirmed to play a vital role in the occurrence and development of ACS. The objective of this prospective, multicenter, observational study is to define immune response and their relationship to the occurrence and progressive of ACS.

Methods
This is a multicenter, prospective, observational longitudinal cohort study. The primary outcome is the incidence of major adverse cardiovascular events (MACE) including in-stent restenosis, severe ventricular arrhythmia, heart failure, recurrent angina pectoris, and sudden cardiac death, and stroke one year later after ACS. Demographic characteristics, clinical data, treatments, and outcomes are collected by local investigators. Furthermore, freshly processed samples will be stained and assessed by flow cytometry. The expression of S100A4, CD47, SIRPα and Tim-3 on monocytes, macrophages and T cells in ACS patients were collected. Follow-up: during hospitalization, 3, 6 and 12 months after discharge.

Discussion
It is expected that this study will reveal the possible targets to improve the prognosis or prevent from occurrence of MACE in ACS patients. Since it’s a multicenter study, the enrollment rate of participants will be accelerated and it can ensure that the collected data are more symbolic and improve the richness and credibility of the test basis.

Ethics and dissemination
This study has been registered in Chinese Clinical Trial Registry Center. Ethical approval was obtained from the Affiliated Hospital of Guizhou Medical University. The dissemination will occur through the publication of articles in international peer-reviewed journals.

Trial Registration
Chinese Clinical Trial Registry: ChiCTR2200066382.
Comparison of valvuloplasty and replacement for surgical treatment of tricuspid infective endocarditis
Authors: Xie Linfeng , Chen Xiaodong , He Jian , Lin Sixian , Chen Xingfeng , Wu Qingsong , Chen Ling , Zhuang Jingxiang , Qiu Zhihuang , Chen Liangwan 
Published: April 2023

Abstract
Background
Owing to the increase in both intravenous drug injections and intracardiac and vascular interventional treatments among drug users, the incidence of infective endocarditis (IE) involving the tricuspid valve, which sits between the two right heart chambers, has gradually increased. This study aimed to compare the clinical outcomes of different surgical procedures for tricuspid infective endocarditis (TIE).

Methods
We retrospectively analyzed fifty-six patients who underwent tricuspid valve surgery at our hospital from January 2006 to August 2019. All patients were diagnosed with TIE and indicated a need for surgery. Perioperative and follow-up data were collected to summarize and analyze the clinical outcomes of different surgical approaches, including tricuspid valvuloplasty (TVP) and tricuspid valve replacement (TVR) for TIE.

Results
Cardiopulmonary bypass (CPB) time, aortic cross-clamp (ACC) time, postoperative mechanical ventilation time, and intensive care unit (ICU) stay time were shorter in the TVP group than in the TVR group. Additionally, the incidence of red blood cell transfusion and postoperative complications was lower in the TVP group than in the TVR group. The postoperative 30-day mortality rates were similar between both the groups. Fifty-two patients were followed up for an average of 5.50 ± 3.79 years. The postoperative 3-, 5-, and 7-year survival rates were 100%, 100%, and 95.5% in the TVP group and 96.7%, 96.7%, and 96.7% in the TVR group, respectively. The 5-year and 10-year reoperation rates were 0% and 0% in the TVP group and 6.7% and 20% in the TVR group, respectively.

Conclusion
Both TVR and TVP for TIE significantly improved the functional status of the heart with satisfactory efficacy. TVP was found to be superior to TVR in reducing the need for postoperative blood transfusions, reducing the risk of postoperative complications, and reducing the need for long-term reoperations.