bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ovarian hyperstimulation that truly matters: Admissions, severity and prevention strategies
Authors: Medwin Chase , Rozen Genia , Agresta Franca , Nassar Nassar , Polyakov Alex 
Published: April 2023

IntroductionOvarian hyperstimulation syndrome (OHSS) is a common but serious complication of in vitro fertilisation. Despite available strategies to reduce OHSS incidence, a small proportion of patients will develop the clinically significant disease with substantial morbidity. Efforts toward better understanding and the prevention of severe disease are required to improve patient outcomes.AimsThe aims are to: (1) formulate clinically relevant OHSS classification for inpatient settings and data collection/reporting; (2) estimate OHSS prevalence requiring hospital admission in Victoria; and (3) determine the extent of OHSS preventability with clinical strategies.Materials and MethodsThis retrospective cohort study included all OHSS admissions in a tertiary referral centre, January 2016–December 2021, which included approximately 40% of all cases of hospitalisation for OHSS in the State of Victoria. Patient characteristics, treatment regimes, fertility treatment outcomes, timing classification, and clinical markers of disease severity were studied. Patients were classified as having mild, moderate, or severe OHSS with a novel inpatient classification system.ResultsOf 199 OHSS cases presenting to the tertiary institution, 107 were classified as moderate/severe, with no significant difference between age, body mass index, length of stimulation and follicle number between mild/moderate and severe groups. There were more cases of early hyperstimulation (137) compared to late (62) presentation, of which 53% were severe. The average length of stay overall was 3.1 days, and 5.2 days for severe presentations. In 15% of severe cases, an agonist trigger was used.ConclusionsThe overall prevalence of OHSS requiring hospital admission appears to be low (approximately 0.6% of all stimulated cycles). Established risk factors may not accurately predict clinically relevant OHSS risk. Further monitoring, clinician and patient education are required to minimise the risk of significant OHSS that results in hospital admissions.
Early experience with pure laparoscopic donor hepatectomy: comparison with open donor hepatectomy and non‐donor laparoscopic hepatectomy
Authors: Linn Yun Le , Chong Yvette , Tan Ek‐Khoon , Koh Ye‐Xin , Cheow Peng‐Chung , Chung Alexander Y. F. , Chan Chung‐Yip , Jeyaraj Prema Raj , Goh Brian K. P. 
Published: April 2023

AbstractBackgroundPure laparoscopic donor hepatectomy (L‐DH) has seen a rise in uptake in recent years following the popularization of minimally invasive modality for major hepatobiliary surgery. Our study aimed to determine the safety and compare the perioperative outcomes of L‐DH with open donor hepatectomy (O‐DH) and laparoscopic non donor hepatectomy (L‐NDH) based on our single institution experience.MethodsEighty of 113 laparoscopic hemi‐hepatectomies performed between 2015 and 2022 met study inclusion criteria. Of these, 11 were L‐DH. PSM in a 1:2 ratio of L‐DH versus L‐NDH and 1:1 ratio of L‐DH versus O‐DH were performed, identifying patients with similar baseline clinicopathological characteristics.ResultsAfter 2:1 matching, the L‐DH cohort were significantly younger (P < 0.001) and had lower ASA scores (P < 0.001) than the L‐NDH cohort. L‐DH was associated with a longer median operating time (P < 0.001) and shorter median postoperative stay (P < 0.001) than L‐NDH. After 1:1 matching, there were no significant differences in baseline demographic between the L‐DH and O‐DH cohorts. L‐DH was associated with lower median blood loss (P = 0.040) and shorter length of stay compared to O‐DH (P = 0.004). There were no significant differences in recipient outcomes for both cohorts.ConclusionL‐DH can be adopted safely by surgeons experienced in L‐NDH and ODH. It is associated with decreased blood loss and shorter length of stay compared to O‐DH.
Inter‐grader reliability in the Danish screening programme for diabetic retinopathy
Authors: Thykjær Anne Suhr , Andresen Jens , Andersen Nis , Bek Toke , Heegaard Steffen , Hajari Javad , Schmidt Laugesen Caroline , Möller Sören , Pedersen Frederik Nørregaard , Kawasaki Ryo , Højlund Kurt , Rubin Katrine Hass , Stokholm Lonny , Peto Tunde , Grauslund Jakob 
Published: April 2023

AbstractPurposeThe Danish Registry of Diabetic Retinopathy includes information from >200 000 patients who attends diabetic retinopathy (DR) screening in Denmark. Screening of patients with uncomplicated type 2 diabetes is often performed by practicing ophthalmologists, while patients with type 1 and complicated type 2 diabetes attends screening at hospitals. We performed a clinical reliability study of retinal images from Danish screening facilities to explore the inter‐grader agreement between the primary screening ophthalmologist and a blinded, certified grader.MethodsInvitations to participate were sent to screening facilities across Denmark. The primary grader uploaded fundus photographs with information on estimated level of DR (International Clinical Diabetic Retinopathy scale as 0 [no DR], 1–3 [mild, moderate or severe nonproliferative DR {NPDR}], or 4 [proliferative DR {PDR}]), region of screening, image style, and screening facility. Images were then regraded by a blinded, certified, secondary grader. Weighted kappa analysis was performed to evaluate agreement.ResultsFundus photographs from 230 patients (458 eyes) were received from practicing ophthalmologists (52.6%) and hospital‐based grading centres (47.4%) from all Danish regions. Reported levels of DR by the primary graders were 66.8%, 12.2%, 13.1%, 1.3% and 5.5% for DR levels 0–4. The overall agreement between primary and secondary graders was 93% (κ = 0.83). Based on screening facility agreement was 96% (κ = 0.89) and 90% (κ = 0.76) for practicing ophthalmologists and hospital‐based graders.ConclusionIn this nationwide study, we observed a high overall inter‐grader agreement and based on this, it is reasonable to assume that reported DR gradings in the screening programme in Denmark, accurately reflect the truth.
Evaluating the integration hypothesis: A meta‐analysis of the ICSEY project data using two new methods
Authors: Abu‐Rayya Hisham M. , Berry John W. , Sam David L. , Grigoryev Dmitry 
Published: April 2023

AbstractThe Integration Hypothesis states that acculturating migrants who adopt the integration strategy (i.e. being doubly engaged, in both their heritage culture and in the larger national society) will have better psychological and socio‐cultural adaptation than those who adopt any other strategy (Assimilation, Separation or Marginalization). This hypothesis was supported in the original evaluation of the ICSEY project data, using the mean adaptation scores for individuals in the four acculturation clusters. This conclusion was further supported by an analysis that used scores that were derived from the two underlying dimensions. This paper further evaluates this hypothesis meta‐analytically using two new methods: Cultural Involvement and Cultural Preference; and Euclidean Distance. The results showed that these two methods provided support for the integration hypothesis, for both psychological adaptation and socio‐cultural adaptation. The pattern of relationships was stronger for positive than for negative indicators of adaptation. Theoretical and practical implications of the results are discussed.
U3 snoRNA‐mediated degradation of ZBTB7A regulates aerobic glycolysis in isocitrate dehydrogenase 1 wild‐type glioblastoma cells
Authors: Dong Weiwei , Liu Yunhui , Wang Ping , Ruan Xuelei , Liu Libo , Xue Yixue , Ma Teng , E Tiange , Wang Di , Yang Chunqing , Lin Hongda , Song Jian , Liu Xiaobai 
Published: April 2023

AbstractAimsThe isocitrate dehydrogenase (IDH) phenotype is associated with reprogrammed energy metabolism in glioblastoma (GBM) cells. Small nucleolar RNAs (snoRNAs) are known to exert an important regulatory role in the energy metabolism of tumor cells. The purpose of this study was to investigate the role of C/D box snoRNA U3 and transcription factor zinc finger and BTB domain‐containing 7A (ZBTB7A) in the regulation of aerobic glycolysis and the proliferative capacity of IDH1 wild‐type (IDH1WT) GBM cells.MethodsQuantitative reverse transcription PCR and western blot assays were utilized to detect snoRNA U3 and ZBTB7A expression. U3 promoter methylation status was analyzed via bisulfite sequencing and methylation‐specific PCR. Seahorse XF glycolysis stress assays, lactate production and glucose consumption measurement assays, and cell viability assays were utilized to detect glycolysis and proliferation of IDH1WT GBM cells.ResultsWe found that hypomethylation of the CpG island in the promoter region of U3 led to the upregulation of U3 expression in IDH1WT GBM cells, and the knockdown of U3 suppressed aerobic glycolysis and the proliferation ability of IDH1WT GBM cells. We found that small nucleolar‐derived RNA (sdRNA) U3‐miR, a small fragment produced by U3, was able to bind to the ZBTB4 3′UTR region and reduce ZBTB7A mRNA stability, thereby downregulating ZBTB7A protein expression. Furthermore, ZBTB7A transcriptionally inhibited the expression of hexokinase 2 (HK2) and lactate dehydrogenase A (LDHA), which are key enzymes of aerobic glycolysis, by directly binding to the HK2 and LDHA promoter regions, thereby forming the U3/ZBTB7A/HK2 LDHA pathway that regulates aerobic glycolysis and proliferation of IDH1WT GBM cells.ConclusionU3 enhances aerobic glycolysis and proliferation in IDH1WT GBM cells via the U3/ZBTB7A/HK2 LDHA axis.
Does the presence of a general counsel in top management affect securities class action lawsuits?
Authors: Hsu Audrey Wen‐Hsin , Liu Sophia 
Published: April 2023

AbstractResearch Question/IssueThis study investigates the effect of the presence of a firm's general counsel on the top management team on the likelihood that a US publicly traded company is targeted by a securities class action (SCA).Research Findings/InsightsUsing a US sample of class action lawsuits against publicly traded companies, we provide evidence that firms whose top management includes the general counsel (TMC) are less likely to be involved in SCAs. We further investigate the association of the presence of a TMC with the subsequent four litigation outcomes: market reaction to the lawsuits, duration of the lawsuit process, dismissal of the lawsuit, and the settlement approved by the courts. We find that firms with a TMC experience more favorable consequences on all four dimensions of litigation outcomes. The results hold after controlling for endogeneity, unobserved firm‐related omitted variable bias, and monitoring mechanisms.Theoretical/Academic ImplicationsThe findings support that establishing a TMC acts as an effective governance mechanism in reducing corporate litigation risk and adverse legal outcomes.Practitioner/Policy ImplicationsOur evidence suggests that a TMC can help monitor operating and financial decisions. This study suggests that Section 307 of the Sarbanes–Oxley Act (SOX) works in terms of explicitly emphasizing the general counsel's responsibility. Thus, this study offers insights to policymakers who are interested in enhancing the function of the governance mechanism by which a corporate general counsel can influence the capital market.
Self‐reported THC content and associations with perceptions of feeling high among cannabis consumers
Authors: Lineham Jesse , Wadsworth Elle , Hammond David 
Published: April 2023

AbstractIntroductionFew studies have examined consumer knowledge and communication of tetrahydrocannabinol (THC) content among cannabis consumers, including potential differences by cannabis legislation. The study sought to: (i) examine self‐reported knowledge of THC content across 10 cannabis products; (ii) examine self‐reported intoxication levels; and (iii) examine association between self‐reported THC levels and intoxication levels.MethodsRepeat cross‐sectional surveys were conducted in Canada and the United States in September–November 2020 as part of the International Cannabis Policy Study. Respondents were past 12‐month cannabis consumers, aged 16–65 (n = 13,689). A weighted logistic regression model examined the association between expected intoxication of dried flower, jurisdiction and frequency of cannabis use.ResultsAcross all 10 cannabis products, approximately two‐thirds of consumers did not know the quantitative THC level of the cannabis product they last used. Qualitative levels of THC (e.g., ‘low’ or ‘high’ THC) showed moderate correspondence with quantitative self‐reported THC levels for most products. Approximately half of consumers across all products reported achieving their desired intoxication level at last use, with higher levels among more frequent consumers and Canadian consumers of dried flower (F = 2.54, p = 0.019).Discussion and ConclusionsOverall, comprehension of THC levels in cannabis products is low among consumers in both illegal and legal markets.
Culturally constituted universals: Evidential basis of belief matters
Authors: Haskaraca Feride Nur , Ilgaz Hande 
Published: April 2023

AbstractDifferences in the sequence with which children pass the tasks in Wellman and Liu's (2004) theory of mind (ToM) battery is increasingly bringing into question the universal and cultural specifics of children's developing understanding of others' minds. Children from China, Iran, and Turkey pass the knowledge access (KA) task of the battery earlier than they pass the diverse beliefs (DB) task (e.g., Selcuk et al., 2018). This pattern is the reverse of what has been documented with children from Australia and the US (e.g., Peterson et al., 2005). This paper presents three studies with Turkish samples that explore the possible reasons for developmental sequence and performance differences in the ToM battery. Study 1 investigated Turkish‐speaking adults' judgments of appropriateness for different epistemic verbs as used in the DB and false belief (FB) tasks. Study 2 investigated whether adults' performance (i.e., accuracy, reaction time) on FB tasks were affected by culturally preferred uses of these verbs. Collectively these studies showed that adults found different epistemic language (“guess,” “think,” and the Turkish‐specific “falsely think”) to be appropriate for different belief‐based tasks. However, there was no difference in adults' performance based on epistemic language. In Study 3, Turkish‐speaking preschoolers' performance in belief‐related tasks based on variations in epistemic language and epistemic features (i.e., presence of evidence) was investigated. Among five modifications, Turkish children benefited only from a modification that involved the manipulation of the epistemological basis for ambiguous beliefs (i.e., visual evidence for belief).Research Highlights
Turkish adults find different epistemic language (“guess,” “think,” and the Turkish‐specific “falsely‐think”) to be appropriate for different belief‐based tasks (diverse and false belief tasks).
Turkish adults’ performance on false belief (FB) tasks is not affected by epistemic language.
Turkish children perform better in diverse beliefs (DB) task if an epistemological basis for ambiguous beliefs (i.e., visual evidence for either belief) is provided.
‘Good jobs’, training and skilled immigration
Authors: Mountford Andrew , Wadsworth Jonathan 
Published: April 2023

AbstractHas skilled immigration into the UK led to a reduction in the training of native‐born workers? To address this concern, this paper describes a theoretical model where immigration can affect the training of native‐born workers both positively and negatively, and where its effects may differ according to the characteristics of the migrant and of the training firm's sector. It then investigates this issue empirically using UK Labour Force Survey data from 1995 to 2018. At the aggregate level, there is a small positive association between skilled immigration and native training rates. However, a more disaggregated analysis finds that the relationship between immigration and native training depends on the skill level of the immigrant, the skill level of trainees, and the sector into which immigration occurs. In particular, traded goods sectors show a positive association between training of UK‐born workers and both unskilled and skilled immigration. In non‐traded high‐wage sectors, the association between skilled immigration and UK‐born training is negative. These findings highlight the importance of allowing for heterogeneous effects from immigration when formulating policy or when modelling immigration's effects across the wider economy.
An exceedingly rare cause of neonatal shock and the value of point‐of‐care ultrasound
Authors: Yang Yun , Zhang Xin , Fang Lingyun , Yang Yali 
Published: April 2023

AbstractWe present a case of a 13‐day‐old neonate with shock who was diagnosed with congenital variation of aortic arch and critical coarctation of aorta by cardiac point‐of‐care ultrasound. Finally, surgery confirmed the anomalies. This case demonstrates the value of cardiac point‐of‐care ultrasound in detecting congenital anomalies of great vessels in neonates and may be beneficial in clinical management.
The structure of microbial communities in redoximorphic microsites of Gleysol
Authors: Samoilova Ekaterina , Tejnecký Václav , Kopecky Jan , Drábek Ondřej , Stovicek Adam , Vokurková Petra , Rapoport Daria , Němeček Karel , Buresova‐Faitova Andrea , Chotěborský Rostislav , Patrmanová Tereza , Hromasová Monika , Sagova‐Mareckova Marketa 
Published: April 2023

AbstractMicrobial communities were studied in redoximorphic microsites of highly heterogeneous Gleysol at a mm scale using 16S and 18S amplicon sequencing to demonstrate if the composition of soil microbes reflects the differences in ferric and ferrous micro‐sites. In both explored gley horizons with redoximorphic features (Bg2 and Cg), ferric mottles were significantly enriched with total P and Fe and depleted of O, Si, Al, K and Ca compared with the adjacent ferrous groundmass (SEM–EDS). Ferric mottles were determined as Fe oxide coatings and hypocoatings. In Bg2, both prokaryotic and micro‐eukaryotic communities differed significantly between mottles and groundmass in composition of operational taxonomic units (OTUs) and in proportions of phyla, reflecting heterogeneities in the soil properties there. Mottles in Bg2 were characterized by increased proportion of Proteobacteria, decreased proportion of Acidobacteriota among prokaryotes and by dominance of a single proteobacterial OTU from Anaplasmataceae compared to all other samples. The composition of micro‐eukaryotes showed an opposite trend, as micro‐eukaryotes of Bg2 groundmass were unique among the other horizons, while micro‐eukaryotes of Bg2 mottles had similar composition to neighbouring horizons. Microbial communities of adjacent samples were not more similar to each other than communities of randomly selected ones in Bg2 horizon. That suggests that at mm scale, the sample distance does not represent the driving factor of microbial community composition and that the adjacent samples differ rather due to physicochemical factors. The spatial organization of microbial communities revealed in Bg2 has not reappeared in similarly organized Cg horizon, probably due to other overriding factors. The differences revealed between Bg2 and Cg horizons, including granulometric composition, content of crystalline Fe, exchangeable Al, and organic carbon, as well as exposition to groundwater, were discussed as possible reasons of the distinct organization in Cg. The similarity of pro−/eukaryotic communities of adjacent and non‐adjacent couples suggests no distance decay pattern at a mm scale. The agreement between patchiness in soil properties and microbial communities was revealed for the first time and confirms the importance of microscale patterns in soil.
Migrants’ transnational social positioning strategies in the middle classes
Authors: Stock Inka 
Published: April 2023

AbstractThis paper examines the influence of class on migrants’ social positioning strategies in transnational spaces. It contributes to debates about the processes of transnational class‐making and class formation. Going beyond an analysis of class in socio‐economic terms, the paper focuses on peoples’ (changing) subjective understandings of middle‐class membership as a relevant factor in migrants’ transnational social positioning strategies. Based on qualitative interview data with middle‐class migrants in Germany, the presentation relates their experiences with downward social mobility before and after migration to their subjective perspectives on middle‐class membership over time and in different places. The findings show that middle‐class performance is shaped by migration experiences but also shapes peoples’ mobility trajectories and therefore influences and promotes different transnational lifestyles.
Writing differently with film: An animated video on gender, leadership, and language
Authors: Biehl Brigitte , Schönfeld Katerina 
Published: April 2023

AbstractThe animated video “Leadership and Discourse” (original title: “Führung und Sprache”) (4:05 min) is produced by us (a filmmaker and a scholar) and stands as an artistic research contribution that is published on the GWO website (https://bcove.video/3yBUL04). It links to and develops forms of “writing differently” in organization studies with moving images, colors, and sound. Drawing on feminist research, it visualizes how language creates a view on leadership as white, heterosexual, and masculine that excludes women and non‐binary individuals, queer people, and people of color. The male leader stereotype “stands” his ground and dominates all others. The video also shows how marginalized positions may find their form when they act in solidarity, reject misogynist vocabulary and hate‐speech, redefine words, and create new terms. In a way that a text cannot, the film allows viewers to experience gender and leadership as a product and artifact of discursive practices. It invites viewers to affectively relate to the content and encourages them to re‐imagine ourselves and others in organizations and leadership relationships beyond binary gender stereotypes. This written article serves as an academic framing, a common standard for artistic research, offering an interpretation of the video and situating the theoretical contribution. We theorize how artistic research as “writing differently” can challenge dominant forms of knowledge production and may support learning and leadership development with alternative, reflective, and experiential approaches and materials.