bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Localized Version of the Method of Fundamental Solutions in a Multi-level Context
Authors: Gáspár Csaba 
Published: March 2023

The Method of Fundamental Solutions is applied to the Laplace equation. Instead of using the traditional approach with external source points and boundary collocation points, the original domain decomposed into a lot of smaller, overlapping subdomains, and the Method of Fundamental Solutions is used to the individual local subdomains. After eliminating the local source points, local schemes are obtained. Instead of constructing a global scheme, the local subproblems are solved sequentially, in an iterative way. This mimics a multiplicative Schwarz method with overlapping subdomains, which assures the convergence of the method. Combining the iteration with a simple Seidel-type method, the resulting iteration is used as a smoothing procedure of a multi-level method. The points belonging to the coarse and fine levels are defined by a quadtree-generated cell system controlled by the boundary of the original domain. The multi-level character of the obtained method makes it possible to reduce the necessary number of iterations, that is, the overall computational cost can be significantly reduced. Moreover, the solution of large and ill-conditioned systems is completely avoided. The method is illustrated through several numerical test examples.
Effects of black pepper, tulsi, peppermint, garlic, black cumin, papaya, cinnamon and patent probiotics on growth performance of broiler
Authors: Amin Mohammad Rohul , Khokon Md Mehedi Hasan , Akter Nasrin , Imran Md Nurul Al , Uddin Md Jasim , Reza Md Ahsanur 
Published: March 2023

The experiment was conducted in Department of Physiology and Pharmacology, FANSVM, PSTU to study the effects of seven indigenous medicinal plants [black pepper (Piper nirgum), tulsi (Ocimum sanctum), peppermint (Mentha piperita), garlic (Allium sativum), black cumin (Nigella sativa), papaya (Carica papaya), cinnamon (Cinnamomum verum)] and two patent probiotics (SS Bio® and Poultrystar Sol®) on the growth performance (body weight and FCR) in broiler. The effects of black pepper, tulsi, peppermint, garlic, black cumin, papaya, cinnamon, SS Bio® and Poultrystar Sol® on hematological parameters (TEC, Hb and PCV) and biochemical parameter (blood glucose) were also observed. One hundred broiler were randomly divided into ten groups (A, B, C, D, E, F, G, H, I and J), each consisting of ten broiler. Group A was kept as control. 10% water extract of black pepper (seed), tulsi (leaves), peppermint (leaves), garlic (bulbs), black cumin (seed), papaya (leaves), cinnamon (bark) were administered orally to the broiler of group B, C, D, E, F, G and H, respectively. Broiler of group I and J received orally SS Bio® and Poultrystar Sol®, respectively. Black pepper, tulsi, peppermint, garlic, black cumin, papaya, cinnamon, SS Bio® and Poultrystar Sol® were significantly (p<0.01 and p<0.05) increased body weight and FCR up to the experimental period. TEC was significantly (p<0.05) increased at garlic treated broiler. After treatment with peppermint, garlic, black cumin, papaya, cinnamon, SS Bio® and Poultrystar Sol®, Hb content increased significantly (p<0.05) in broiler. Black pepper, tulsi, peppermint, black cumin, papaya, SS Bio® and Poultrystar Sol® treatment significantly (p<0.01 and p<0.05) increased PCV in broiler. Peppermint, garlic, black cumin, papaya, cinnamon, SS Bio® and Poultrystar Sol® caused significantly (p<0.01 and p<0.05) increased blood glucose. Tulsi decreased (p<0.05) significantly blood glucose. The present study reveal that indigenous medicinal plants can be used as alternatives to patent probiotics in broiler.
Asian Australas. J. Biosci. Biotechnol. 2019, 4 (3), 135-141
STRATEGI PROGRAM “MORNING ZONE” DI TRAX FM JAKARTA DALAM MENINGKATKAN JUMLAH PENDENGAR
Authors: Junito Daniel Bawono 
Published: March 2023

Tujuan dilakukannya penelitian ini adalah untuk mengetahui strategi yang dilakukan program Morning Zone di 101.4 Trax FM Jakarta dalam meningkatkan jumlah pendengar pada bulan Januari – Juli 2019 dan untuk mengetahui hambatan-hambatan yang dialami selama melakukan proses strategi program tersebut. Adapun dalam penelitian ini, peneliti menggunakan pendekatan kualitatif dengan metode analisis deskriptif dan teknik pengumpulan data dilakukan dengan cara wawancara mendalam. Dalam penelitian ini pula, peneliti menggunakan konsep srategi program yang dikemukakan oleh Morissan dalam bukunya berjudul Manajemen Media Penyiaran cetakan tahun 2008. Hasil penelitian berdasarkan wawancara mendalam yang dilakukan peneliti dengan Key Informan dan 3 Informan menunjukan kecocokan atau kesamaan jawaban antara Key Informan, Informan 1, dan Informan 2 atas pertanyaan-pertanyaan yang diajukan oleh peneliti mengenai strategi program. Adapun hasil penelitian ini diperkuat dengan adanya data jumlah pendengar program Morning Zone yang peniliti peroleh dari RnD MRA Group, baik sebelum penelitian ini dilakukan dan setelah penelitian ini dilakukan. Kesimpulan dari hasil penelitian yang dilakukan ini adalah strategi program yang dilakukan oleh stasiun radio 101.4 Trax FM Jakarta yang terdiri 4 strategi, yaitu dari perencanaan program, produksi dan pembelian program, eksekusi program, serta pengawasan dan evaluasi program menunjukan keberhasilan dalam meningkatkan jumlah pendengar program Morning Zone pada bulan Januari – Juli 2019.Kata Kunci: Strategi Program, Morning Zone, 101.4 Trax FM, Meningkatkan Jumlah Pendengar.
PENGARUH PESAN KAMPANYE ANTI MEROKOK TERHADAP SIKAP MASYARAKAT
Authors: Sitindaon Christina Meiliana 
Published: March 2023

Abstract This research was conducted in order to analyze the impact given related to information on smoking bans delivered through social media which is expected to be able to give effect to the public regarding smoking. And this research was conducted with a quantitative approach using survey methods conducted by distributing questionnaires as data collection. The number of respondents in this study were 97 people who were sampled using the Non-Probability Sampling Technique. Non-Probability sampling technique used in this study is purposive sampling where respondents in this study have criteria that will be used as samples, namely people who have seen or know information about smoking bans. Data analysis in this study used Univariate and Regression Test, after being analyzed the data was processed using SPSS. And the results of this study that Expression of Anti-Smoke Messages and Reception of Anti-Smoke Messages have a significant effect on Perceived Peer Smoking Norms, while Expression of Anti-Smoke Messages and Reception of Anti-Smoke Messages have a significant effect on Smoking Intentions. So in conclusion Information about smoking bans delivered through social media can affect a person's way of smoking because people who receive information submitted in the form of words or submitted by posting pictures on social media can make someone interested in reading and commenting on smoking-related information.Keywords: (Campaign PR, Anti Smoke Messages, Social Media, Intentions, Attitude)
STRATEGI MANAJEMEN KRISIS PUBLIC RELATIONS DALAM MENGEMBALIKAN KEPERCAYAAN KARYAWAN
Authors: Pratiwi Pebri Yanti , Haninda Ayu Rahma 
Published: March 2023

Kepercayaan pegawai PT Sigma Cemerlang Sinergi menurun terhadap perusahaan sejak hak pegawai tidak dipenuhi dan mengakibatkan timbulnya krisis. Penelitian ini mengungkap bagaimana strategi manajemen krisis public relations PT Sigma Cemerlang Sinergi dalam mengembalikan kepercayaan pegawai pasca krisis dengan analisis strategi manajemen krisis. Teori konsep yang digunakan yaitu strategi manajemen krisis PR oleh Firsan Nova (2017) di dalam buku yang berjudul "Crisis Public Relations" dan teori peran dan fungsi PR dari Cutlip-Center-Broom (2010). Metode kualitatif digunakan dengan pengumpulan data primer melalui wawancara mendalam dan data sekunder dari studi dokumentasi. Informan penelitian ini adalah Site Manager, Kepala bidang Human Resource and General Affair, dan salah satu karyawan tetap perusahaan. Hasil data wawancara dianalisis menggunakan tahapan koding (open-axial-selective coding). Temuan penelitian menunjukkan bahwa PT Sigma Cemerlang Sinergi tidak memiliki divisi khusus public relationsnamun aktivitas public relations telah dilakukan. Empat tahapan yang dilakukan PT Sigma Cemerlang Sinergi dalam mengatasi krisis (preventions, preparations, actions, dan recovery). Penelitian lanjutan dari penelitian ini dapat melakukan transferabilitas pada konteks dan subjek penelitian yang berbeda.
PREPARATION AND EVALUATION OF COMPRESSION-COATED MINI TABLETS FOR CHRONOPHARMACEUTICAL DRUG DELIVERY
Authors: EŞİM Özge , HASÇİÇEK Canan 
Published: March 2023

Objective: This study aims to prepare and evaluate time-controlled drug delivery system of telmisartan. Telmisartan has low aqueous solubility, which is its major drawback. The solubility of the drug enhanced by using solid dispersion method and compression coated chronotherapeutic tablets were formulated.
Material and Method: Solid dispersion of telmisartan was prepared by melting method. Direct compression method was used to prepare telmisartan containing core tablets and tablets were coated by compression-coating method. Prepared tablets were characterized in terms of hardness, diameter, and thickness. In order to demonstrate the pulsatile release, the tablets were subjected to USP Apparatus II dissolution test.
Result and Discussion: Solid dispersion of telmisartan increased the solubility of telmisartan significantly (p
Augmented Reality: New Approach in Distance Education Studentsâ€™ Learning Process
Authors: Marisa Marisa , Prabowo Suryo , Dhini Bachriah Fatwa , Aji Kristina Anugerah 
Published: March 2023

The Educational Technology Study Program of Universitas Terbuka offers online practical courses. However, students face difficulties to complete their learning objectives in these courses. This study aims to provide appropriate media and adequate learning experiences for distance education students using augmented reality. Design of this study uses ADDIE model. Population of this study are students and tutors in 20 regional offices. The results showed that augmented reality media in online tutorials was quite effective in providing learning experiences. Augmented reality can bring reality into classroom for distance education students and assist them practice their courses. Even so, students still face obstacles in using the media, namely the incompatibility of student devices with the media, and minimum required tools to produce instructional video program. Therefore, a synchronous learning session between students and tutor is necessary.
Eosinophilic esophagitis-associated epithelial remodeling may limit esophageal carcinogenesis
Authors: Fuller Annie D. , Karami Adam L. , Kabir Mohammad Faujul , Klochkova Alena , Jackson Jazmyne L. , Mu Anbin , Tan Yinfei , Klein-Szanto Andres J. , Whelan Kelly A. 
Published: March 2023

IntroductionUnder homeostatic conditions, esophageal epithelium displays a proliferation/differentiation gradient that is generated as proliferative basal cells give rise to suprabasal cells then terminally differentiated superficial cells. This proliferation/differentiation gradient is often perturbed in esophageal pathologies. Basal cell hyperplasia may occur in patients with gastroesophageal reflux disease (GERD), a condition in which acid from the stomach enters the esophagus, or eosinophilic esophagitis (EoE), an emerging form of food allergy. While GERD is a primary risk factor for esophageal cancer, epidemiological data suggests that EoE patients do not develop esophageal cancer.MethodsIn order to investigate the impact of EoE and esophageal cancer specifically on the cellular landscape of esophageal epithelium, we perform single cell RNA-sequencing in murine models of EoE and esophageal cancer, specifically esophageal squamous cell carcinoma (ESCC). We further evaluate modules of co-expressed genes in EoE- and ESCC-enriched epithelial cell clusters. Finally, we pair EoE and ESCC murine models to examine the functional relationship between these pathologies.ResultsIn mice with either EoE or ESCC, we find expansion of cell populations as compared to normal esophageal epithelium. In mice with EoE, we detect distinct expansion of 4 suprabasal populations coupled with depletion of 2 basal populations. By contrast, mice with ESCC display unique expansion of 2 basal populations and 1 suprabasal population, as well as depletion of 2 suprabasal populations. Senescence, glucocorticoid receptor signaling, and granulocyte-macrophage colony-stimulating factor pathways are associated with EoE-enriched clusters while pathways associated with cell proliferation and metabolism are identified in ESCC-enriched clusters. Finally, our in vivo data demonstrate that exposure to EoE inflammation limits tumor burden of esophageal carcinogenesis.DiscussionOur findings provide the first functional investigation of the relationship between EoE and esophageal cancer and suggest that esophageal epithelial remodeling events occurring in response to EoE inflammation may limit esophageal carcinogenesis. This investigation may have future implications for leveraging allergic inflammation-associated alterations in epithelial biology to prevent and/or treat esophageal cancer.
Biomechanical factors in the open gingival embrasure region during the intrusion of mandibular incisors: A new model through finite element analysis
Authors: Zhang Yubohan , Gao Jie , Wang Xu , Wang Jihong , Zhang Xu , Fang Shishu , Wang Wei , Ma Yanning , Jin Zuolin 
Published: March 2023

Introduction: Open gingival embrasure (OGE) is a common complication in adults following clear aligner therapy and the influence of gingival or alveolar bone biotype on OGE is of great concern. Unfortunately, due to the limited number of patients with clearaligner therapy and the clinical methods to distinguish the gingival biotype of patients being invasive, it is difficult to carry out clinical studies on the gingival or alveolar bone biotype of the OGE. In the meanwhile, the detailed biomechanics of the occurrence of OGE remains unknown. The goal of this study was to establish a new model to simulate the virtual space region, namely, the OGE region, to investigate the relationship between alveolar bone biotype and the occurrence of OGE, and explore potential biomechanical factors related to OGE.Methods: The OGE region in the interproximal space was established using a filler with a very low modulus of elasticity (1 × 10−6 MPa). To illustrate the biomechanics of OGE more exhaustively, a line was created at the top of the alveolar crest along the proximal tooth root. FEA was then used to analyze the biomechanics of the surrounding tissues, the OGE region and the line at the top of the alveolar crest along the proximal tooth root of the central incisor under two different labial bone thicknesses (thick and thin) with an axial inclination of 80°, 90° and 100°.Results: During intrusion of the incisors in clear aligner therapy, as inclination increased or bone tissue became thinner, the stress in the surrounding tissues [tooth root, alveolar crest, and periodontal ligament (PDL)] was greater. In the OGE region and interproximal alveolar crest, the strain increased with increasing inclination and labial bone thinning. The results from the line at the top of the alveolar crest along the proximal tooth root showed more detailed biomechanics: In all groups, stress and strain were focused on the mesial-labial alveolar crest. Interestingly, our results also demonstrated that when OGE occurs, other complications may arise, including root resorption and bone dehiscence.
Mechanism exploration and prognosis study of Astragali Radix-Spreading hedyotis herb for the treatment of lung adenocarcinoma based on bioinformatics approaches and molecular dynamics simulation
Authors: Guo Junfeng , Zhao Yuting , Wu Xuanyu , Li Ganggang , Zhang Yuwei , Song Yang , Du Quanyu 
Published: March 2023

Background: Herb pair of Astragali Radix (AR) and Spreading Hedyotis Herb (SH) has been frequently prescribed in clinical for the treatment of lung cancer owing to its favorable efficacy. Yet, the mechanism under the therapeutic effects remained unveiled, which has limited its clinical applications, and new drug development for lung cancer.Methods: The bioactive ingredients of AR and SH were retrieved from the Traditional Chinese Medicine System Pharmacology Database, with the targets of obtained components predicted by Swiss Target Prediction. Genes related to lung adenocarcinoma (LUAD) were acquired from GeneCards, OMIM and CTD databases, with the hub genes of LUAD screened by CTD database. The intersected targets of LUAD and AR-SH were obtained by Venn, with David Database employed to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Survival analysis of the hub genes of LUAD was carried out using TCGA-LUAD dataset. Molecular docking of core proteins and active ingredients was performed by Auto-Dock Vina software, followed by molecular dynamics simulations of protein-ligand complexes with well-docked conformations.Results: 29 active ingredients were screened out with 422 corresponding targets predicted. It is revealed that AR-SH can act on various targets such as EGFR, MAPK1, and KARS by ursolic acid (UA), Astragaloside IV(ASIV), and Isomucronulatol 7,2′-di-O-glucoside (IDOG) to alleviate the symptoms of LUAD. Biological processes involved are protein phosphorylation, negative regulation of apoptotic process, and pathways involved are endocrine resistance, EGFR tyrosine kinase inhibitor resistance, PI3K-Akt, and HIF-1 pathway. Molecular docking analysis indicated that the binding energy of most of the screened active ingredients to proteins encoded by core genes was less than −5.6 kcal/mol, with some active ingredients showing even lower binding energy to EGFR than Gefitinib. Three ligand-receptor complexes including EGFR-UA, MAPK1-ASIV, and KRAS-IDOG were found to bind relatively stable by molecular dynamics simulation, which was consistent with the results of molecule docking.Conclusion: We suggested that the herb pair of AR-SH can act on targets like EGFR, MAPK1 and KRAS by UA, ASIV and IDOG, to play a vital role in the treatment and the enhancement of prognosis of LUAD.
Identification and immuno-infiltration analysis of cuproptosis regulators in human spermatogenic dysfunction
Authors: Zhao Ming , Yu Wen-Xiao , Liu Sheng-Jing , Deng Ying-Jun , Zhao Zi-Wei , Guo Jun , Gao Qing-He 
Published: March 2023

Introduction: Cuproptosis seems to promote the progression of diverse diseases. Hence, we explored the cuproptosis regulators in human spermatogenic dysfunction (SD), analyzed the condition of immune cell infiltration, and constructed a predictive model.Methods: Two microarray datasets (GSE4797 and GSE45885) related to male infertility (MI) patients with SD were downloaded from the Gene Expression Omnibus (GEO) database. We utilized the GSE4797 dataset to obtain differentially expressed cuproptosis-related genes (deCRGs) between SD and normal controls. The correlation between deCRGs and immune cell infiltration status was analyzed. We also explored the molecular clusters of CRGs and the status of immune cell infiltration. Notably, weighted gene co-expression network analysis (WGCNA) was used to identify the cluster-specific differentially expressed genes (DEGs). Moreso, gene set variation analysis (GSVA) was performed to annotate the enriched genes. Subsequently, we selected an optimal machine-learning model from four models. Finally, nomograms, calibration curves, decision curve analysis (DCA), and the GSE45885 dataset were utilized to verify the predictions’ accuracy.Results: Among SD and normal controls, we confirmed that there are deCRGs and activated immune responses. Through the GSE4797 dataset, we obtained 11 deCRGs. ATP7A, ATP7B, SLC31A1, FDX1, PDHA1, PDHB, GLS, CDKN2A, DBT, and GCSH were highly expressed in testicular tissues with SD, whereas LIAS was lowly expressed. Additionally, two clusters were identified in SD. Immune-infiltration analysis showed the existing heterogeneity of immunity at these two clusters. Cuproptosis-related molecular Cluster2 was marked by enhanced expressions of ATP7A, SLC31A1, PDHA1, PDHB, CDKN2A, DBT, and higher proportions of resting memory CD4+ T cells. Furthermore, an eXtreme Gradient Boosting (XGB) model based on 5-gene was built, which showed superior performance on the external validation dataset GSE45885 (AUC = 0.812). Therefore, the combined nomogram, calibration curve, and DCA results demonstrated the accuracy of predicting SD.Conclusion: Our study preliminarily illustrates the relationship between SD and cuproptosis. Moreover, a bright predictive model was developed.
Thromboinflammatory response is increased in pancreas transplant alone versus simultaneous pancreas-kidney transplantation and early pancreas graft thrombosis is associated with complement activation
Authors: Rydenfelt Kristina , Kjøsen Gisle , Horneland Rune , Ludviksen Judith Krey , Jenssen Trond Geir , Line Pål-Dag , Tønnessen Tor Inge , Mollnes Tom Eirik , Haugaa Håkon , Pischke Søren Erik 
Published: March 2023

BackgroundPancreas transplant alone (PTA) recipients are more affected by pancreas graft thrombosis, and graft loss compared to simultaneous pancreas-kidney (SPK) recipients. The pathophysiology is unknown, but an increased immune response has been suggested in the PTA recipients. In this observational study, we compared perioperative thromboinflammation between PTA (n=32) and SPK (n=35) recipients, and between PTA recipients with (n=14) versus without (n=18) early graft thrombosis.MethodsWe measured C-reactive protein (CRP), plasma markers of activated coagulation and complement, and cytokines preoperatively and daily during the first postoperative week.ResultsPreoperatively, coagulation and complement activation markers were comparable between PTA and SPK recipients, while cytokine concentrations were higher in SPK recipients (TNF, IL-8, IP-10, MCP-1, MIP-1α; all p&lt;0.05). On the first postoperative day, PTA recipients had higher coagulation activation, measured as thrombin-antithrombin complex (TAT), than SPK recipients (p=0.008). In the first postoperative week, PTA recipients showed higher relative cytokine release (IL-6, IL-8, G-CSF, IP-10, MCP-1, and MIP-1α; all p&lt;0.05) while SPK recipients showed higher absolute cytokine concentrations (TNF, IL-1ra, IL-8, MIP-1α, and IL-4; all p&lt;0.05). PTA and SPK recipients showed similar terminal complement complex (TCC, sC5b-9) activation. On the first postoperative day, TCC (OR 1.2 [95% CI 1.0-1.5] for 0.1 CAU/ml increase, p=0.02) and CRP (OR 1.2 [95% CI 1.0-1.3] for 10 mg/L increase, p=0.04) were associated with an increased risk of early graft thrombosis. TCC was specific for graft thrombosis, while CRP increased with several complications. PTA recipients with compared to those without graft thrombosis had higher TCC pre- (p=0.04) and postoperatively (p=0.03).ConclusionThe relative increase in postoperative thromboinflammatory response was more pronounced in PTA recipients. Complement activation was associated with an increased risk of graft thrombosis. This study indicates that innate immune activation rather than elevated levels may affect early postoperative pancreas graft thrombosis.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT01957696, identifier NCT01957696