bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are Rotations and Translations of Head Posture Related to Performance Parameters in Three Different Dynamic Tasks?
Authors: Saad Nabil , Moustafa Ibrahim Moustafa , Ahbouch Amal , Alsaafin Nour , Oakley Paul A. , Harrison Deed E. 
Published: July 2023

This study assessed the relationship between head posture displacements and biomechanical parameters in three different tasks. One hundred male and female students (20 ± 3yrs) were assessed via the PostureScreen Mobile app to quantify postural displacements of head rotations and translations including: 1) the cranio-vertebral angle (CVA) (°), 2) anterior head translation (AHT) (cm), 3) lateral head translation in the coronal plane (cm), and 4) lateral head side bending (°). Biomechanical parameters during gait and jumping were measured using the G-Walk sensor. The assessed gait spatiotemporal parameters were cadence (steps / min), speed (m / s), symmetry index, % left and right stride length (% height), and right and left propulsion index. The pelvic movement parameters were: 1) tilt symmetry index, 2) tilt left and right range, 3) obliquity symmetry index, 4) obliquity left and right range, 5) rotation symmetry index, and 6) rotation left and right range. The jump parameters measured were: 1) flight height (cm), 2) take off force (kN), 3) impact Force (kN), 4) take off speed (m / s), 5) peak speed (m / s), 6) average speed concentric phase (m / s), 7) maximum concentric power (kW), 8) average concentric power (kW) during the counter movement jump (CMJ), and 9) CMJ with arms thrust (CMJAT). At a significance-level of p ≤ 0.001, moderate to high correlations (0.4 &amp;lt; r &amp;lt; 0.8) were found between CVA, AHT, lateral translation head and all the gait and jump parameters. Weak correlations (0.2 &amp;lt; r &amp;lt; 0.4) were ascertained for lateral head bending and all the gait and jump parameters except for gait symmetry index and pelvic symmetry index, where moderate correlations were identified (0.4 &amp;lt; r &amp;lt; 0.6). The findings indicate moderate to high correlations between specific head posture displacements, such as CVA, lateral head translation and AHT with the various gait and jump parameters. These findings highlight the importance of considering head posture in the assessment and optimization of movement patterns during gait and jumping. Our findings contribute to the existing body of knowledge and may have implications for clinical practice and sports performance training. Further research is warranted to elucidate the underlying mechanisms and establish causality in these relationships, which could potentially lead to the development of targeted interventions for improving movement patterns and preventing injuries.
Sponging of five tumour suppressor miRNAs by lncRNA-KCNQ1OT1 activates BMPR1A/BMPR1B-ACVR2A/ACVR2B signalling and promotes chemoresistance to hepatocellular carcinoma
Authors: Banerjee Soma , Majumdar Swagata , Chakraborty Anannya , Das Sumit , Gorain Mahadeo , Chatterjee Soumyabrata , Dey Indrashish , Bhowmik Sayantani , Ghosh Suchandrima , Banerjee Sanjana , Ahammed Sk , Chowdhury Abhijit , Datta Simanti , Kundu Gopal C 
Published: July 2023

Abstract

Diverse mechanisms have been established to understand chemoresistance of hepatocellular carcinoma (HCC), but the contribution of non-coding RNAs are not surveyed well. We aimed here to explore the lncRNA/miRNA axis in hepatitis C and B virus infected HCC to investigate the mechanism of chemoresistance and to classify a potential therapeutic target for HCC. The small RNA transcriptome, and qRT-PCR validation with the liver tissues of both HCV and HBV infected HCC patients revealed that miR-424-5p/miR-136-3p/miR-139-5p/miR-223-3p/miR-375-3p were the most downregulated five miRNAs in HCC compared to normal (log2fold change ≤-1.5, Padj≤0.05).In-silicopathway analysis with the validated targets of each miRNA depicted that the signalling pathways regulating pluripotency of stem cells commonly targeted by the all five miRNAs. Subsequent validation by 3’UTR-luciferase assays and western blot analysis disclosed that these five miRNAs impeded either same or diverse genes, but all from BMP signaling pathways including BMPR1A/BMPR1B by miR-139-5p, miR-136-5p & miR-375-3p and ACVR2A/ACVR2B by miR424-5p & miR223-3p. Furthermore, restoration of each miRNA in Huh7/SNU449 cells inhibited phosphorylation of downstream SMAD1/5 and ERK1/2, and attenuated EMT/stemness/sphere formation/chemoresistance/invasion/migration of cells. To investigate the mechanism of suppression of these miRNAs, “DIANA” prediction tool was employed and lncRNA-KCNQ1OT1 was retrieved as interacting partner of all five miRNAs. Ago2-RNA-immuno-precipitation/in vitro RNA pull-down assays revealed that lncRNA-KCNQ1OT1 physically interacted and sequestered all the five miRNAs in the cytoplasm. Hence, KCNQ1OT1 was deleted in Huh7/SNU449 cells using CRISPR-technology and observed regression of oncogenic properties with enhanced chemosensitivity and reduced metastasis of cells. Shrinkage of tumor size/volume in NOD-SCID mice injected with KCNQ1OT1-K/O cells further strengthened our observations. Thus, lncRNA-KCNQ1OT1 is the main regulator, which reduces the level of beneficiary miRNAs in the tumor milieu and modulates BMP signaling to promote chemoresistance to HCC suggesting lncRNA-KCNQ1OT1 might have robust potential to be a therapeutic target for HCC.
Co-application of humic acid, potassium dihydrogen phosphate and melatonin (osmo-regulators) ameliorate the effects of drought stress in Barley (Hordeum vulgare L.)
Authors: Zafar Fizza , Noreen Zahra , Shah Anis Ali , Usman Sheeraz 
Published: July 2023

Abstract
Purpose
Drought has an adverse impact on the production and growth of cereals globally. Due to drought stress, cereals’ cultivation declined day by day, worldwide. Hence, ultimate yield does not fulfill the required demand. The current research investigated the consequences of drought stress on morpho-physiological, yield and biochemical parameters of barley plants and a comparison of different osmo-regulators and their ameliorating capacity towards drought stress.
Methods
A pot trial was held in a completely randomized (CR) design with three replicates manner to investigate the role of humic acid, potassium dihydrogen phosphate and melatonin (osmo-regulators) synergistic application in ameliorating drought stress. Three barely varieties (Haider-93, Sultan-17 and Jau-17) were selected for this experiment. The treatments applied were as follows; humic acid (400 ppm), potassium dihydrogen phosphate (20 ppm) and melatonin (0.5 mM) with two water levels i.e., Control (normal watering) and drought stress (stop watering).
Results
Results indicated that foliar application of all osmo-regulators improved propagation, antioxidants, proteins, chlorophyll, mineral contents and productivity parameters, while alleviate Malondialdehyde content, hydrogen peroxide and relative membrane permeability value studied under drought stress and non-drought stress. The maximum yield was noticed in Jau-17 plants given humic acid in control and drought stress in Jau-17. The order of effectiveness of osmo-regulators in this study was humic acid > melatonin > potassium dihydrogen phosphate.
Conclusion
Osmo-regulators examined in this study had potential role in combating against drought stress and could also be effective for various other abiotic stresses.
Blood Transfusion Is Associated with Hepatitis C in the Older Drinking Population: Analysis of the National Health and Nutrition Examination Survey from 2013 to 2018
Authors: Ji Kangkang , Shen Yucheng , Chen Wei , Zhang Leiming , Xu Kangjie , Meng Hai , Li Li , Sun Minli 
Published: July 2023

Abstract
BACKGROUND: Although blood transfusion and hepatitis C might be related, the exact association has not been reported. This study aimed to investigate whether blood transfusion increases the prevalence of hepatitis C infection among the older drinking population.
METHODS: This study included an older population with drinking habits participating in the National Health and Nutrition Examination Survey from 2013 to 2018. We used weighted multivariable logistic regression models to examine the association between hepatitis C and blood transfusion. A nomogram was employed to evaluate the prevalence of hepatitis C in older drinking people. Propensity matching (PSM) was conducted to balance the confounding factors. Logic models following the PSM were used to validate the association between blood transfusion and hepatitis C.
RESULTS: Among the 2972 individuals surveyed, hepatitis C virus (HCV) infection was reported in 6.43% (37/575) of the transfused group and 2.33% (56/2397) of the non-transfused group. The prevalence of HCV infection was significantly higher in the transfused group than in the non-transfused group. Blood transfusion history was associated with hepatitis C (odds ratio 11.430, 95% confidence interval 5.321–24.554) in the weighted multivariable logistic analysis. The association was particularly pronounced in people aged 60–69 years (odds ratio 14.907, 95% confidence interval 6.459–34.405). The nomogram suggested blood transfusion and age as the two major risk factors for HCV infection. Moreover, the results after PSM still showed that blood transfusions increase the risk of HCV infection.
CONCLUSION: Blood transfusion increases the risk of HCV infection in older drinking patients, with a higher risk, particularly in those aged 60–69 years.
The effect of long-term exposure to heated tobacco products on the central nervous system using novel in vivo experimental methods
Authors: Yamada Hidetada , Yamazaki Yu , Takebayashi Yoshiko , Yazawa Kyosuke , Sasanishi Miwako , Motoda Atsuko , Nakamori Masahiro , Morino Hiroyuki , Takahashi Tetsuya , Maruyama Hirofumi 
Published: July 2023

Abstract

Heated tobacco products (HTPs) are new products being promoted by the tobacco industry as having a reduced potential for harm compared with conventional cigarettes. However, there is insufficient information on the health risks of long-term exposure to HTPs on the central nervous system (CNS). To determine the health risks of HTP use, valid and reproducible in vivo protocols must be established. Therefore, we propose a simple experimental method to evaluate the impact of long-term exposure to HTPs on the CNS in an amyloid mouse model. App knock-in mice were exposed to HTPs for 16 weeks, five days per week. Serum cotinine concentration was used to validate the HTP exposure model. Histological analysis indicated that HTPs had minimal effects on amyloid pathology. However, gene ontology analysis was performed on differentially expressed genes in the cerebral cortex that had thresholds of |log2 Fold Change| > 1 and non-adjusted p value < 0.05. The results indicated that exposure to HTPs mainly affected non-inflammatory pathways in the CNS. Further studies are required to determine the safety of HTPs on the CNS. Our experimental method provides a convenient means for evaluating these parameters.
Mitigating Membrane Fouling in Dairy Wastewater Treatment System: Assessing the Effects of Integrated 3DP Turbulence Promoter
Authors: Al-Tayawi Aws N. , Gulyás Nikolett Sz. , Gergely Gréta , Fazekas Ákos Ferenc , Szegedi Balázs , Hodúr Cecilia , Lennert József Richárd , Kertész Szabolcs 
Published: July 2023

Abstract
Dairy factories annually generate increasing amounts of wastewater, which can cause eutrophication due to high concentrations of amino acids and lipids. To address this issue, membrane technology has emerged as a promising solution, but membrane fouling remains a significant challenge, since it can couse decreased flux, lessen membrane rejection performance and increased energy demand. This study aimed to reduce membrane fouling by integrated a Three-Dimensional Printed (3DP) turbulence promoter into an ultrafiltration dead-end cell and varying stirring speeds. Two mathematical models, Hermia and Resistance-in-series, were used to analyze the fouling process. According to both models, the cake layer formation model indicated the most prevalent fouling mechanism. The specific energy demand, permeate flux, membrane rejection, and membrane reversible and irreversible resistances were measured, calculated and compared. The results suggest that the combination of integrated 3DP turbulence promoter and high stirring speeds can effectively reduce membrane fouling in a dairy wastewater treatment module.
Light-driven electron transfer by Quantum vibronic ratcheting
Authors: Fleming Graham , Roy Partha , Widel Zachary , Liu Rui , Valdiviezo Jesús , Zhang Peng , Leonardo Cristina , Mansergh Jarrett , Chowdhury Sutirtha , Beratan David , Therien Michael 
Published: July 2023

Abstract
The optical control of coherence to improve and create a new molecular function is a grand challenge in science. In this work, we present a synthetic strategy to build a donor-donor-acceptor (D1D2A) supramolecular construct and tailor vibronic coherence to leverage an efficient long-range electron-transfer by defeating the thermodynamic energy trap imposed by Boltzmann statistics. The relaxed D1* lies 0.35 eV below the D2* state. By a combined transient IR and two-dimensional electronic vibrational spectroscopy study we show that selective excitation of the vibronic bands of lower energy primary donor (D1) leads to substantial rapid (< 200 fs) formation of a charge-transfer state (D1D2+A−), followed by hole transfer leading to (D1+D2A−). This provides direct evidence of electron transfer (secondary donor D2 to A) induced by a vibronic quantum ratcheted ‘uphill’ energy transfer from D1 to D2. Thus, it lays out a rational for improving efficiency of solar energy conversion and expanding the spectral bandwidth in synthetic light harvesting systems.
Presenteeism among Healthcare Workers in Samarinda and Related Factors – Study Using Stanford Presenteeism Scale 6 (SPS-6) Questionnaire Modified in Indonesian
Authors: Linda Linda , Adi Nuri Purwito , Werdhani Retno Asti , Soemarko Dewi Sumaryani , Friska Dewi 
Published: July 2023

Abstract

Background
Working while sick or also known as presenteeism is a risk factor that can have a negative impact on workers health and productivity. Presenteeism among healthcare workers will also increase the risk of patient safety. However, there is insufficient study on presenteeism in Samarinda. Thus, this study aims to determine the proportion of presenteeism, and factors related to presenteeism among healthcare workers in Samarinda.
Methods
This study used a cross-sectional study design, using primary data collected online during the period of October-November 2022. The sample used was convenience sampling with a minimum of 130 samples. SPSS version 26 was used to carry out binary logistic regression analysis.
Result
A total of 136 respondents completed the questionnaire, with the proportion of presenteeism was 31.6%. The dominant factors related to presenteeism among healthcare workers in Samarinda were stress factor (p = 0.001; aOR = 17.998; CI 95%=3.247–99.762) and work experience < 2 years (p = 0.048; aOR = 2.760; CI 95%=1.011–7.534). Pseudo-R square value was 33.2%.
Conclusion
Compared to other studies, the proportion of presenteeism obtained in this study was lower. Stress factor and work experience < 2 years were the dominant factors related to presenteeism. It is advisable for healthcare management to implement strategies to reduce stressors at the workplace, routine screening to detect stress and increasing job resources. For healthcare workers, it is advisable to increase self resources, nurture positive attitudes and relations with co-workers, and manage stress. Further study needed to explore other factors related to presenteeism.
Knowledge, Attitude, and Practices of Complementary and Alternative Medicine: A Patients' Perspective
Authors: Makarem Nisrine N , Brome Dayana , Sawaf Souad Susan , Sayyid Abdallah , Romani Maya 
Published: July 2023

Abstract
Background: Complementary and alternative medicine (CAM) includes a wide set of domains, including mind-body interventions, herbs and supplements, and alternative medical systems. Although CAM is commonly practiced in Lebanon, it is still not integrated into mainstream medicine. There is a paucity of data regarding patients’ utilization, familiarity, and attitudes toward CAM.
Objectives: The main aim of this study was to assess the knowledge, attitudes, and practices toward CAM among patients.
Material and Methods: A cross-sectional, questionnaire-based survey was conducted among 213 patients attending family medicine clinics at the American University of Beirut Medical Center (AUBMC).
Results: Among the respondents, 78.9% indicated that they had used CAM in the past six months. Thirty-three percent use CAM regularly as daily activity and as a way for health and immunity maintenance. The motive behind using CAM was related to CAM’s accessibility (63.3%), experience with CAM (64.8%), and not its less expensiveness (82%) or failure of traditional medicine (91.3%). Patients were most familiar with relaxation therapy (90.4%), massage (89.6%), meditation (87.3%), herbal medicine (86.5%), naturopathy (85.1%), yoga (81.7%), spiritual healing/ prayer (60.4%) as well as garlic (93.9%) and ginger (93%). Moderately favorable attitudes towards CAM were reflected by the patients as signified by the slightly above-mean average towards CAM permissiveness (M = 3.67, SD = .56). Approximately 90% of participants indicated that their physicians have never asked them about CAM usage, 76.5% indicated that they did not inform their physician about CAM use, and 70.8% indicated they would utilize CAM services if provided at the AUBMC.
Conclusion:The study findings indicate limited familiarity with CAM, high utilization rates, and positive attitudes toward it. This is the first study in Lebanon to assess knowledge, attitudes, and practices of all 5 CAM domains among patients within a healthcare setting in a major academic medical center as a follow-up on a study that assessed the knowledge, practices, and attitudes of physicians and nurses towards CAM at the same institution.
A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis
Authors: Escande Carlos , Cal Karina , Leyva Alejandro , Rodriguez-Duarte Jorge , Ruiz Santiago , Santos Leonardo , Colella Lucía , Ingold Mariana , Vilaseca Cecilia , Galliussi German , Ziegler Lucía , Peclat Thais , Bresque Mariana , Handy Rachel , King Rachel , Reis Larisa Menezes dos , Espasandin Camila , Breining Peter , Dapueto Rosina , Lopez Andres , Thompson Katie , Agorrody Guillermo , DeVallance Evan , Meadows Ethan , Lewis Sara , Barbosa Gabriele Santana , de Souza Leonardo Osbourne Lai , Chichierchio Marina Santos , Valez Valeria , Aicardo Adrian , Contreras Paola , Vendelbo Mikkel , Jakobsen Steen , Kamaid Andres , Porcal Williams , Calliari Aldo , Verdes Jose , Du Jianhai , Wang Yekai , Hollander John , White Thomas , Radi Rafael , Moyna Guillermo , Quijano Celia , O'Doherty Robert , Moraes-Vieira Pedro Manoel , Holloway Graham , Leonardi Roberta , Mori Marcelo , Camacho-Pereira Juliana , Kelley Eric , Duran Rosario , Lopez Gloria , Batthyany Carlos , Chini Eduardo 
Published: July 2023

Abstract
Obesity-related type II diabetes (diabesity) has increased global morbidity and mortality dramatically. Previously, the ancient drug salicylate demonstrated promise for the treatment of type II diabetes, but its clinical use was precluded due to high dose requirements. In this study, we present a nitroalkene derivative of salicylate, 5-(2-nitroethenyl)salicylic acid (SANA), a molecule with unprecedented beneficial effects in diet-induced obesity (DIO). SANA reduces DIO, liver steatosis and insulin resistance at doses up to 40 times lower than salicylate. Mechanistically, SANA stimulated mitochondrial respiration and increased creatine-dependent energy expenditure in adipose tissue. Indeed, depletion of creatine resulted in the loss of SANA action. Moreover, we found that SANA binds to creatine kinases CKMT1/2, and downregulation CKMT1 interferes with the effect of SANA in vivo. Together, these data demonstrate that SANA is a first-in-class activator of creatine-dependent energy expenditure and thermogenesis in adipose tissue and emerges as a candidate for the treatment of diabesity.
WITHDRAWN: Copper Nanoparticles on expression of LuxS of the genes in Pseudomonas aeruginosa strains anti-Biofilm formation
Authors: Ahmed Mais E. , Mohammed Luma 
Published: July 2023

Abstract

The resistance to broad spectrum antimicrobials therapy such Pseudomonas aeruginosa, . Biofilms are major virulence factors to resist antibiotics; in this concern the need for providing new alternatives for antibiotics is becoming an urgent requirement,Now day therapies and applications based treatments felid nanoparticle. copper Oxide nanoparticles, were produced from MDR and strong biofilm producer P. aeruginosa isolate by biological method, against P. aeruginosa colonization of the biofilm and LuxSgene expression.This study was aimed to explore whether green synthesized copper nanoparticles (CuNPs) can function as an anti-biofilm agent of P. aeruginosa bacteria. The nanoparticles was synthesized from cell free extract of P. aeruginosa. Characterization of biosynthesized copper nanoparticles was carried out to determine the chemical and physical properties of the product usinging AFM, TEM ,XRD and UV visible spectrometry. The hexagonal structure was confirmed by XRD, size range was marked 13-19nm by TEM, was used to confirm the surface morphology. AFM analysis used to reveal the roughness and distribution of nanoparticles. UV–visible spectra of the synthesized nanoparticles recorded maximum peak at 300 nm. Copper nanoparticles showed remarkable biofilm inhibitory on multidrug resistant at (32 μg/ml) sub Minimum Inhibitory Concentration (MIC), CuNPs exhibited remarkable effect against P. aeruginosa .Strong biofilm producer strains were incubated with 1ml of sub MIC of CuNPs for 24 -48 hrs at 37C . The current study has proven that copper oxide nanoparticles possess the ability to act as anti-biofilm agents against P. aeruginosa. This was evidenced by their significant downregulation of LuxS gene expression, The results indicated a major down-regulation in LuxS expression after exposure to CuNPs, suggesting the antimicrobial agent against multidrug-resistant P. aeruginosa infections.
Bio mediated synthesis of ZnS @ ZnO nanocomposite from Cucumis melo pulp and chicken feathers: Photodegradation of dyes and antibacterial activities.
Authors: Nandisha P S , . sowbhagya , Pasha M.A , Umesha B , Harshitha M 
Published: July 2023

Abstract
Synthesis of efficient photocatalyst in the form of ZnS @ ZnO nanocomposite from Cucumis melo pulp and waste chicken feather powder as fuel and source of oxygen and sulphur respectively is reported in this work. XRD, SEM, TEM, PL EDS, FT-IR, DRS, and EIS techniques are used to investigate the composite's structural, morphological, optical, and electrochemical properties. The SEM analysis confirmed core-shell nanocomposite formation consisting of nano ZnS as the core encapsulated by the nano ZnO shell. The XRD data of ZnS @ ZnO nanocomposite resembled pure crystalline ZnO and ZnS nanoparticles. The intensity and crystal size of nano ZnO, nano ZnS, and ZnS @ ZnO nanocomposite were calculated using the Debye-Scherrer equation and found to be 29, 24.2, and 71 nm, respectively. DRS confirmed the band gap of the synthesized material, which was calculated using a K-M plot and found to be 3.4 eV, 3.5 eV, and 3.04 eV for ZnO, ZnS nanoparticles, and ZnS @ ZnO composite, respectively. The synthesized ZnO-ZnS nanocomposite showed enhanced photocatalytic activity towards MB [92%], RhB [98.4%], and CR [90.9 %] dyes in water under Visible light. Radicals formation was confirmed by the ESR technique. TOC analysis was done to verify the organic dye degradation. ZnS @ ZnO nanocomposite also exhibited potent antibacterial activity.