bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid detection of Yunnan Xiaomila based on lightweight YOLOv7 algorithm
Authors: Wang Fenghua , Jiang Jin , Chen Yu , Sun Zhexing , Tang Yuan , Lai Qinghui , Zhu Hailong 
Published: June 2023

IntroductionReal-time fruit detection is a prerequisite for using the Xiaomila pepper harvesting robot in the harvesting process.MethodsTo reduce the computational cost of the model and improve its accuracy in detecting dense distributions and occluded Xiaomila objects, this paper adopts YOLOv7-tiny as the transfer learning model for the field detection of Xiaomila, collects images of immature and mature Xiaomila fruits under different lighting conditions, and proposes an effective model called YOLOv7-PD. Firstly, the main feature extraction network is fused with deformable convolution by replacing the traditional convolution module in the YOLOv7-tiny main network and the ELAN module with deformable convolution, which reduces network parameters while improving the detection accuracy of multi-scale Xiaomila targets. Secondly, the SE (Squeeze-and-Excitation) attention mechanism is introduced into the reconstructed main feature extraction network to improve its ability to extract key features of Xiaomila in complex environments, realizing multi-scale Xiaomila fruit detection. The effectiveness of the proposed method is verified through ablation experiments under different lighting conditions and model comparison experiments.ResultsThe experimental results indicate that YOLOv7-PD achieves higher detection performance than other single-stage detection models. Through these improvements, YOLOv7-PD achieves a mAP (mean Average Precision) of 90.3%, which is 2.2%, 3.6%, and 5.5% higher than that of the original YOLOv7-tiny, YOLOv5s, and Mobilenetv3 models, respectively, the model size is reduced from 12.7 MB to 12.1 MB, and the model’s unit time computation is reduced from 13.1 GFlops to 10.3 GFlops.DiscussionThe results shows that compared to existing models, this model is more effective in detecting Xiaomila fruits in images, and the computational complexity of the model is smaller.
Paths towards parenthood after repeated treatment failures: a comparative study on predictors of psychological health outcomes in infertile couples persisting in treatments or opting for adoption
Authors: Zurlo Maria Clelia , Cattaneo Della Volta Maria Francesca , Vallone Federica 
Published: June 2023

IntroductionInfertility literature suggests widespread recourse to long-term medical treatments despite evidence of high stress, costs, and adverse effects of repeated treatment failures. However, there is a lack of research comparing predictors of stress and psychological health outcomes between members of infertile couples who – after repeated failures – persist in pursuing medical treatments (PT) with those who opted for quitting treatments and adopting (QTA). Basing on a transactional and multidimensional approach to infertility-related stress and health, the present study aims at exploring individual (socio-demographics; coping strategies) and situational (infertility-related parameters; infertility-related stressors; couple’s dyadic adjustment dimensions) predictors of state-anxiety and depression in male and female partners of PT-infertile couples and of QTA-infertile couples.MethodsParticipants were both members of 176 couples with duration of infertility and a history of medical treatments for at least 3 years (76 PT-infertile couples, 100 QTA-infertile couples). The study variables were compared by study group across genders. Structural equation models (SEM) were used to test main and moderating effects of study variables on state-anxiety and depression by study group and across genders.ResultsMembers of infertile couples quitting treatments and adopting (QTA) reported significantly lower levels of state-anxiety and depression, higher stress related to need for parenthood and rejection of childfree-lifestyle and lower stress related to social and couple’s relationship concerns than those who persist in pursuing medical treatments (PT). Members of infertile couples quitting treatments and adopting (QTA) recurred to a greater extent to active coping strategies (problem-solving/social-support) and to a lower extent to passive coping strategies (avoiding/turning-to-religion), and they reported higher levels of dyadic adjustment. Specificities in main and moderating factors related to state-anxiety and depression by study group and across genders were found.ConclusionFindings should be addressed to provide a comprehensive assessment of both members of infertile couples facing repeated treatment failures to identify risks and resources and develop tailored evidence-based interventions.
Metabolite-disease interaction prediction based on logistic matrix factorization and local neighborhood constraints
Authors: Zhao Yongbiao , Ma Yuanyuan , Zhang Qilin 
Published: June 2023

BackgroundIncreasing evidence indicates that metabolites are closely related to human diseases. Identifying disease-related metabolites is especially important for the diagnosis and treatment of disease. Previous works have mainly focused on the global topological information of metabolite and disease similarity networks. However, the local tiny structure of metabolites and diseases may have been ignored, leading to insufficiency and inaccuracy in the latent metabolite-disease interaction mining.MethodsTo solve the aforementioned problem, we propose a novel metabolite-disease interaction prediction method with logical matrix factorization and local nearest neighbor constraints (LMFLNC). First, the algorithm constructs metabolite-metabolite and disease-disease similarity networks by integrating multi-source heterogeneous microbiome data. Then, the local spectral matrices based on these two networks are established and used as the input of the model, together with the known metabolite-disease interaction network. Finally, the probability of metabolite-disease interaction is calculated according to the learned latent representations of metabolites and diseases.ResultsExtensive experiments on the metabolite-disease interaction data were conducted. The results show that the proposed LMFLNC method outperformed the second-best algorithm by 5.28 and 5.61% in the AUPR and F1, respectively. The LMFLNC method also exhibited several potential metabolite-disease interactions, such as “Cortisol” (HMDB0000063), relating to “21-Hydroxylase deficiency,” and “3-Hydroxybutyric acid” (HMDB0000011) and “Acetoacetic acid” (HMDB0000060), both relating to “3-Hydroxy-3-methylglutaryl-CoA lyase deficiency.”ConclusionThe proposed LMFLNC method can well preserve the geometrical structure of original data and can thus effectively predict the underlying associations between metabolites and diseases. The experimental results show its effectiveness in metabolite-disease interaction prediction.
Migrant and Refugee Youth’s Sexual and Reproductive Health and Rights: A Scoping Review to Inform Policies and Programs
Authors: Aibangbee Michaels , Micheal Sowbhagya , Mapedzahama Virginia , Liamputtong Pranee , Pithavadian Rashmi , Hossain Zakia , Mpofu Elias , Dune Tinashe 
Published: June 2023

Objectives:Migrants and refugee youth (MRY) in Western nations are less likely to participate in sexual reproductive health (SRH) services. Consequently, MRY are more likely to encounter adverse SRH experiences due to limited access to and knowledge of SRH services. A scoping review was conducted to examine MRY’s understanding of and the implications for inclusive sexual and reproductive health and rights (SRHR) programs and policies.Methods:A systematic search of literature across seven academic databases was conducted. Data were extracted following Partners for Dignity and Rights’ Human Rights Assessment framework and analysed using the thematic-synthesis method.Results:38 literature (peer-reviewed, 24 and grey, 14) were considered eligible for inclusion. The findings highlighted significant barriers and the under-implementation of SRHR support and services by MRY. Key policy implications include a need for programs to support MRY’s SRHR education, diversity, equity and inclusiveness and privacy protections.Conclusion:The review shows that the emerging evidence on MRY SRHR suggests gaps in practices for resourcing policies and programs that promote sustainable SRH for vulnerable populations. Policies for MRY’s SRHR should prioritise programs that focus on diversity, equity and inclusion with targeted education and community resourcing strategies for sustainability.
Association between radiomics features of DCE-MRI and CD8+ and CD4+ TILs in advanced gastric cancer
Authors: Huang Huizhen , Li Zhiheng , Xia Yue , Zhao Zhenhua , Wang Dandan , Jin Hongyan , Liu Fang , Yang Ye , Shen Liyijing , Lu Zengxin 
Published: June 2023

Objective: The aim of this investigation was to explore the correlation between the levels of tumor-infiltrating CD8+ and CD4+ T cells and the quantitative pharmacokinetic parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with advanced gastric cancer.Methods: We retrospectively analyzed the data of 103 patients with histopathologically confirmed advanced gastric cancer (AGC). Three pharmacokinetic parameters, Kep, Ktrans, and Ve, and their radiomics characteristics were obtained by Omni Kinetics software. Immunohistochemical staining was used to determine CD4+ and CD8+ TILs. Statistical analysis was subsequently performed to assess the correlation between radiomics characteristics and CD4+ and CD8+ TIL density.Results: All patients included in this study were finally divided into either a CD8+ TILs low-density group (n = 51) (CD8+ TILs &lt; 138) or a high-density group (n = 52) (CD8+ TILs ≥ 138), and a CD4+ TILs low-density group (n = 51) (CD4+ TILs &lt; 87) or a high-density group (n = 52) (CD4+ TILs ≥ 87). ClusterShade and Skewness based on Kep and Skewness based on Ktrans both showed moderate negative correlation with CD8+ TIL levels (r = 0.630–0.349, p &lt; 0.001), with ClusterShade based on Kep having the highest negative correlation (r = −0.630, p &lt; 0.001). Inertia-based Kep showed a moderate positive correlation with the CD4+ TIL level (r = 0.549, p &lt; 0.001), and the Correlation based on Kep showed a moderate negative correlation with the CD4+ TIL level, which also had the highest correlation coefficient (r = −0.616, p &lt; 0.001). The diagnostic efficacy of the above features was assessed by ROC curves. For CD8+ TILs, ClusterShade of Kep had the highest mean area under the curve (AUC) (0.863). For CD4+ TILs, the Correlation of Kep had the highest mean AUC (0.856).Conclusion: The radiomics features of DCE-MRI are associated with the expression of tumor-infiltrating CD8+ and CD4+ T cells in AGC, which have the potential to noninvasively evaluate the expression of CD8+ and CD4+ TILs in AGC patients.
Expression Characterization of ABCDE Class MADS-Box Genes in Brassica rapa with Different Pistil Types
Authors: Zhang Yi , Zhao Tong , Wang Yuqi , Yang Rong , Li Weiqiang , Liu Kaiwen , Sun Nairan , Hussian Iqbal , Ma Xinyan , Yu Hongrui , Zhao Kun , Chen Jisuan , Yu Xiaolin 
Published: June 2023

MADS-box is a vital transcription factor family that functions in plant growth and development. Apart from APETALA2, all genes in the ABCDE model that explain the molecular mechanism of floral organ development belong to the MADS-box family. Carpel and ovule numbers in plants are essential agronomic traits that determine seed yield, and multilocular siliques have great potential for the development of high-yield varieties of Brassica. In this study, ABCDE genes in the MADS-box family from Brassica rapa were identified and characterized. Their tissue-specific expression patterns in floral organs and their differential expression in different pistil types of B. rapa were revealed by qRT-PCR. A total of 26 ABCDE genes were found to belong to the MADS-box family. Our proposed ABCDE model of B. rapa is consistent with that of Arabidopsis thaliana, indicating that ABCDE genes are functionally conserved. These results of qRT-PCR showed that the expression levels of class C and D genes were significantly different between the wild-type (wt) and tetracarpel (tetrac) mutant of B. rapa. Interestingly, the expression of the homologs of class E genes was imbalanced. Therefore, it is speculated that class C, D, and E genes are involved in developing the carpel and ovule of B. rapa. Our findings reveal the potential for the selection of candidate genes to improve yield traits in Brassica crops.
Role of the Department of Clinical Laboratory Diagnostics and Immunology of the Grodno State Medical University in Training Specialist in Clinical Laboratory Diagnostics
Authors: Лелевич С.В. 
Published: June 2023

Специалисты клинической лабораторной диагностики являются крайне востребованными в современной медицине. В 70–80% случаев именно результаты лабораторных исследований являются определяющими при постановке диагноза, проведении дифференциальной диагностики отдельных форм патологии, а также при назначении специфической терапии и контроле за ее осуществлением. Кафедра клинической лабораторной диагностики и иммунологии учреждения образования «Гродненский государственный медицинский университет» обеспечивает образовательный процесс по лабораторным дисциплинам на лечебном, а также медико-диагностическом факультетах по специальностям 1-79 01 01 «Лечебное дело» и 1-79 01 04 «Медико-диагностическое дело». На кафедре осуществляется преподавание студентам ряда лабораторных дисциплин, среди которых клиническая биохимия, лабораторная гематология, клиническая микробиология, а также цитология. Кафедра также принимает участие в реализации учебных программ последипломного образования по клинической лабораторной диагностике, включая проведение курсов повышения квалификации, а также обучение в магистратуре и клинической ординатуре.
Specialists of clinical laboratory diagnostics are extremely in demand in modern medicine. In 70–80% of cases, it is laboratory findings that are decisive for diagnosis, differential diagnosis of some forms of pathology, and for appointment and monitoring of specific therapies. The Department of Clinical Laboratory Diagnostics and Immunology of Grodno State Medical University provides the educational process in laboratory disciplines at the Faculty of General Medicine, as well as at the Faculty of Medical Diagnostics, for specialties 1-79 01 01 "General Medicine" and 1-79 01 04 "Medical Diagnostics". At the Department, students are taught a range of laboratory disciplines, including clinical biochemistry, laboratory hematology, clinical microbiology, and cytology. The department participates in the implementation of postgraduate training programs in clinical laboratory diagnostics, including advanced training courses, as well as training in master’s degree and clinical residency.
Effectiveness of the Laboratory Diagnostics of Tuberculosis Based on the "Fast" Molecular and Genetic (GeneXpert, LineProbeAssay) and Bacteriological Analysis Methods Implemented in the Republican Hospital of the Correctional Institution "Correctional Facility No. 12": Research Results Review
Authors: Виташкевич О.А. , Николенко Е.Н. 
Published: June 2023

Туберкулез сомножественной и широкой лекарственной устойчивостью является глобальной проблемой здравоохранения. В Республике Беларусь, несмотря на резкое снижение заболеваемости в последние годы, число случаев туберкулеза со множественной лекарственной устойчивостью остается достаточно высоким: одна треть вновь диагностированных пациентов с туберкулезом и две трети пролеченных пациентов имеют форму со множественной лекарственной устойчивостью. Сложность эпидемиологической ситуации обусловливает высокие требования к качеству лабораторной диагностики туберкулеза, стандартизации исследований, использованию современных диагностических технологий – автоматизированных диагностических систем, молекулярно-генетических исследований. В статье представлен анализ использования молекулярно-генетических методов (Xpert MTB/Rif, LineProbeAssay) в лабораторной диагностике туберкулеза в сравнении с фенотипическими методами: с использованием автоматизированной системы ВАСТЕС MGIT 960 и классических методов исследования. Анализ проводился на основании данных обследования пациентов с туберкулезом, находившихся на лечении в Республиканской больнице ИУ «ИК № 12» за период с 2012 по 2021 год.
Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis is a global public health problem. Despite a sharp decline in morbidity in recent years in the Republic of Belarus, the number of multidrug-resistant tuberculosis cases remains quite high: one third of newly diagnosed tuberculosis patients and two thirds of treated patients present a multidrug-resistant form. Challenging epidemiological situation determines high requirements for the quality of tuberculosis laboratory diagnostics, tests standardization, for use of modern diagnostic technologies, i.e. automated diagnostic systems, and molecular and genetic testing. The article presents an analysis of molecular genetic methods (Xpert MTB/Rif, LineProbeAssay) applied in laboratory diagnosis of tuberculosis compared with phenotypic methods: by using ВАСТЕС MGIT 960 automated system and conventional testing methods. The analysis was carried out on the basis of the findings of medical examination of tuberculosis patients who were treated at the Republican Hospital of the Correctional Institution "Correctional Facility No. 12" for the period from 2012 to 2021.
Que nous apprend le concours de l’OVE sur la façon dont la recherche aborde la vie étudiante ?
Authors: Rey Olivier 
Published: June 2023

La condition étudiante est un objet de recherche qui s’est développé depuis les années 1990 en France. À travers les prix du concours de l’Observatoire de la vie étudiante, qui récompense chaque année un mémoire ou une thèse, cet article identifie les principales caractéristiques et évolutions des recherches portant sur les questions étudiantes ces vingt dernières années. Il montre à la fois la récurrence d’interrogations classiques sur la question des inégalités dans l’enseignement supérieur, des problématiques en construction sur la réussite étudiante et une attention nouvelle à la diversité des situations et des populations constitutives de l’expérience étudiante. L’intérêt des informations capitalisées par l’OVE, mais aussi leur caractère insuffisamment structuré pose des questions quant à la place de cet organisme au sein du paysage institutionnel de l’enseignement supérieur.
INVESTIGATION OF THE SKIN MICROBIOTA IN DOGS WITH PYODERMA
Authors: Tuyakhov M. F. 
Published: June 2023

The article presents the results of investigation of the skin microbiota in dogs with pyoderma.
The purpose of this study was to study the species composition of the skin microflora of dogs diagnosed with pyoderma and bacterial otitis for the further study of the sensitivity of the isolates to antibiotics in order to develop rational treatment schemes for patients with various forms of pyoderma.
A pyoderma symptom complex was detected in 48 animals, pyoderma itself was observed in 14 (29.17% of cases), acute wet dermatitis in 17 (35.41%), impetigo in 5 (10.42%), and purulent folliculitis in 12 (25 %).
A study of the composition of the skin microflora in dogs showed the presence of pathogens such as S. pseudintermedius, Proteus spp., Pseudomonas aeruginosa, Malassezia pahydermatis, Candida albicans, Essherichia coli. However, the research results also showed the presence of representatives of coagulase-positive cocci – S. aureus (54.1% of all cases) and coagulase-negative S. epidermidis (14.6%).
Representatives of Candida albicans were isolated in only one case (2.1%). Associations of S. aureus with Malassezia pachydermatis fungi were observed in 9 cases (34.6% of the number of cases of Staphylococcus aureus isolation), and in 5 cases (19.2%) with gram-negative Proteus spp.
Recuperación de las experiencias en educación ambiental, una formación inmersiva del docente en la Escuela Normal No. 1 de Toluca.
Authors: Reyes-Banda Sacnicté , Hannz-Sámano Carlos Israel , Arriaga-López Erasmo 
Published: June 2023

La praxis educativa ambiental en la Escuela Normal No. 1 de Toluca, se desarrolla desde diferentes estrategias según los requerimientos académicos y de gestión. En la ubicuidad académica se pretende atender los contenidos de manera secuencial, gradual y con profundidad, bajo la premisa lineal del binomio docencia-investigación, por ello, la perspectiva investigativa de la educación ambiental para este estudio permea en integrar elementos in situ desde y para una formación inmersiva del docente y de la comunidad normalista.
El acercamiento a la comunidad en la institución es derivado del análisis de resultados de la observación no participante, donde se determinó que las primeras acciones deberían estar encaminadas a la sensibilización de la comunidad escolar: directivos, docentes, estudiantes y personal administrativo. En este sentido, se implementaron dos acciones, las cuales fueron: una ceremonia indígena (docentes y estudiantes) y un taller vivencial de Carta de la Tierra con un enfoque en la cosmovisión de los pueblos originarios (docentes), ambos en el marco de la celebración del Día Internacional de la Madre Tierra.
La formación inmersiva del docente y en la comunidad, se vincula desde las diferentes acciones del habitus (fuera y dentro de la institución), el eje de la teoría crítica y el registro desde la investigación educativa bajo la integración cuidadosa y sistémica de la información.
La presente investigación es de tipo cualitativa, en la cual, se aplicó una técnica de encuesta con un instrumento de guía de preguntas a 374 participantes (directivos, docentes, estudiantes y administrativos), con la finalidad de identificar sus conocimientos, su interés en participar en acciones desde la institución en beneficio del medio ambiente y de la comunidad escolar.
Las conclusiones son derivadas del procesos y resultados recopilado de la investigación desarrollada respecto a la perspectiva y prospectiva de la educación ambiental en la Escuela Normal No. 1 de Toluca como agente de cambio, asimismo, es importante continuar con acciones y líneas que contribuyan a reducir el detrimento ambiental actual.