bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preterm birth associated alterations in brain structure, cognitive functioning and behavior in children from the ABCD dataset
Authors: Ji Weibin , Li Guanya , Jiang Fukun , Zhang Yaqi , Wu Feifei , Zhang Wenchao , Hu Yang , Wang Jia , Wei Xiaorong , Li Yuefeng , Manza Peter , Tomasi Dardo , Gao Xinbo , Wang Gene-Jack , Zhang Yi , Volkow Nora D 
Published: June 2023

AbstractBackgroundPreterm birth is a global health problem and associated with increased risk of long-term developmental impairments, but findings on the adverse outcomes of prematurity have been inconsistent.MethodsData were obtained from the baseline session of the ongoing longitudinal Adolescent Brain and Cognitive Development (ABCD) Study. We identified 1706 preterm children and 1865 matched individuals as Control group and compared brain structure (MRI data), cognitive function and mental health symptoms.ResultsResults showed that preterm children had higher psychopathological risk and lower cognitive function scores compared to controls. Structural MRI analysis indicated that preterm children had higher cortical thickness in the medial orbitofrontal cortex, parahippocampal gyrus, temporal and occipital gyrus; smaller volumes in the temporal and parietal gyrus, cerebellum, insula and thalamus; and smaller fiber tract volumes in the fornix and parahippocampal-cingulum bundle. Partial correlation analyses showed that gestational age and birth weight were associated with ADHD symptoms, picvocab, flanker, reading, fluid cognition composite, crystallized cognition composite and total cognition composite scores, and measures of brain structure in regions involved with emotional regulation, attention and cognition.ConclusionsThese findings suggest a complex interplay between psychopathological risk and cognitive deficits in preterm children that is associated with changes in regional brain volumes, cortical thickness, and structural connectivity among cortical and limbic brain regions critical for cognition and emotional well-being.
Polarization in public attitudes toward end-of-life decisions in Israel – A cross-sectional study
Authors: Bodas Moran , Ziv Arnona , Rubin Carmit , Oberman Bernice , Tawil Yoel , Shaulov Adir , Kaplan Giora , Velan Baruch 
Published: June 2023

AbstractObjectivesEnd-of-life (EoL) processes are a complex socio-normative and ethical phenomenon. This study aimed to generate a database of public opinion in Israel concerning EoL processes and decisions and to identify differences in attitudes across subgroups in the population, particularly based on experience as a family caregiver of a dying patient.MethodsThis cross-sectional study was performed in late March 2022. The study utilized an online sample of 605 adults over the age of 50 including those who accompanied a loved one to their death in the last 3 years. Participants were requested to provide their opinions and attitudes on several aspects of EoL decisions, including truth-telling, medically assisted dying, EoL procedures, pre-death actions, and family caregivers’ engagement.ResultsWhile only 27% and ∼30% of participants support artificial respiration or feeding (respectively) of terminally ill patients, 66% support analgesic treatment, even at the risk of shortening life. The data show an association between religiosity and agreement with life-extending procedures. For example, while 83% of seculars support medically assisted dying, only 59% and 26% of traditional and religious respondents support it. However, no statistically significant differences were observed in support of family involvement in EoL process in any sociodemographic variable.Significance of resultsThe results of this study suggest that the Israeli public is relatively polarized on several issues about EoL processes, specifically patient autonomy and medically assisted dying. Yet, at the same time, there is a consensus among the Israeli public about certain EoL elements, particularly the importance of family caregivers in the EoL decision-making process.
Combining ability, heterosis, and heterobeltiosis to select highly productive F1 hybrids of habanero pepper (Capsicum chinense Jacq.)
Authors: Rodríguez-Llanes Yaritza , Pérez-Brito Daisy , Guzmán-Antonio Adolfo , Mijangos-Cortés Javier O. , Iglesias-Andreu Lourdes G. , Canto- Flick Adriana , Avilés-Viñas Susana A. , Pijeira-Fernández Gema , Santana-Buzzy Nancy 
Published: June 2023

AbstractSelection of lines from segregating generations and breeding hybrids to exploit heterosis or heterobeltiosis is an effective tool for improving economically important traits in the genus Capsicum. The objective of this study was to identify high potential parents to obtain high-yielding F1 hybrids using a Line × Tester (8 × 2) mating design in the Habanero pepper improvement programme. Ten parents and 16 hybrids were evaluated in order to determine their values of general combining ability, specific combining ability, heterosis, and heterobeltiosis. Parent NKA-11 had the highest values of GCA for different quantitative variables of the fruit, which does it suitable for future improvement works, and tester RNJ-04 showed the highest value of GCA for fruit length. The quantitative variables evaluated confirm a significant genetic variability among the Habanero pepper genotypes studied. The best hybrids were NEK-03xRNJ-04, NBA-06xRNJ-04, AKN-07xRNJ-04, and RKI-10xRNJ-04, which showed their high productive potential with values between 3.13 and 4.92 Kg/Pta, a quality, that would open to them the national market for fresh consumption. Based on the GCA values of the parents and heterosis of the progenies, it is concluded hybridization would be the most appropriate genetic improvement method to increase both yield (YP) and the number of fruits for plant.
Energy Conversion by Magnetic Reconnection in Multiple Ion Temperature Plasmas
Authors: Dargent J. , Toledo‐Redondo S. , Divin A. , Innocenti M. E. 
Published: June 2023

AbstractMagnetic reconnection is a process that converts magnetic energy into kinetic energy, both bulk and thermal. We study the energy partition in magnetotail reconnection in the presence of cold ion populations of ionospheric origin using kinetic simulations. We compare two simulations with one or two ion populations, but same ion moments. The ion distribution in the simulation with cold ions therefore corresponds to a non‐Maxwellian distribution with a large tail. The global energy budget does not change in the two cases, but when focusing on sub‐populations, the hot ion population (i.e., the tail of the velocity distribution function) gains more energy than the cold ion population (i.e., the core of the distribution). Hot and cold ions also gain different percentages of bulk and thermal energy.
Near Infrared Spectral Radiance at Multiple Wavelengths From Io's Volcanoes 1: The Low Spatial Resolution Night‐Time Galileo NIMS Data Set
Authors: Davies Ashley Gerard , Veeder Glenn J. 
Published: June 2023

AbstractWe have calculated surface‐leaving spectral radiances for 285 detections of volcanic thermal emission from Io observations made by the Galileo Near Infrared Mapping Spectrometer (NIMS) in the 0.7‐ – 5.2‐μm wavelength range, the first such analysis of the entire low‐spatial‐resolution night‐time data set. Most of these detections are of 53 individual hot‐spots. We establish that 4.8‐μm spectral radiance is a good proxy for total thermal emission from a hot spot. Many detections reported here have not been previously modeled. This set of hot‐spot detections is derived from NIMS night‐time observations obtained between June 1996 (orbit G1) and October 2001 (Orbit I32), where the hot‐spot is sub‐pixel. Modeling of the spectra yields total thermal emission from each volcano in each observation, as well as the 2:5‐μm spectral radiance ratio and radiant flux density. Surface‐leaving spectral radiance is derived at 2.0, 3.5, 3.8, 4.8, and 5.0 μm allowing direct comparison with data obtained by other spacecraft and ground‐based telescope data. The most energetic volcanic eruptions are identified. We find an unusual number of sources in a C30 observation suggesting that a vigorous volcanic activity was taking place simultaneously in multiple locations, possibly tidally controlled.
Multi-dimensional band structure spectroscopy in the synthetic frequency dimension
Authors: Cheng Dali , Lustig Eran , Wang Kai , Fan Shanhui 
Published: June 2023

AbstractThe concept of synthetic dimensions in photonics provides a versatile platform in exploring multi-dimensional physics. Many of these physics are characterized by band structures in more than one dimensions. Existing efforts on band structure measurements in the photonic synthetic frequency dimension however are limited to either one-dimensional Brillouin zones or one-dimensional subsets of multi-dimensional Brillouin zones. Here we theoretically propose and experimentally demonstrate a method to fully measure multi-dimensional band structures in the synthetic frequency dimension. We use a single photonic resonator under dynamical modulation to create a multi-dimensional synthetic frequency lattice. We show that the band structure of such a lattice over the entire multi-dimensional Brillouin zone can be measured by introducing a gauge potential into the lattice Hamiltonian. Using this method, we perform experimental measurements of two-dimensional band structures of a Hermitian and a non-Hermitian Hamiltonian. The measurements reveal some of the general properties of point-gap topology of the non-Hermitian Hamiltonian in more than one dimensions. Our results demonstrate experimental capabilities to fully characterize high-dimensional physical phenomena in the photonic synthetic frequency dimension.
Trimethoprim resistance in surface and wastewater is mediated by contrasting variants of thedfrBgene
Authors: Kneis David , Lemay-St-Denis Claudèle , Cellier-Goetghebeur Stella , Elena Alan X , Berendonk Thomas U , Pelletier Joelle N , Heß Stefanie 
Published: June 2023

AbstractTrimethoprim (TMP) is a low-cost, widely prescribed antibiotic. Its effectiveness is increasingly challenged by the spread of genes coding for TMP-resistant dihydrofolate reductases: dfrA, and the lesser-known, evolutionarily unrelated dfrB. Despite recent reports of novel variants conferring high level TMP resistance (dfrB10 to dfrB21), the prevalence of dfrB is still unknown due to underreporting, heterogeneity of the analyzed genetic material in terms of isolation sources, and limited bioinformatic processing. In this study, we explored a coherent set of shotgun metagenomic sequences to quantitatively estimate the abundance of dfrB gene variants in aquatic environments. Specifically, we scanned sequences originating from influents and effluents of municipal sewage treatment plants as well as river-borne microbiomes. Our analyses reveal an increased prevalence of dfrB1, dfrB2, dfrB3, dfrB4, dfrB5, and dfrB7 in wastewater microbiomes as compared to freshwater. These gene variants were frequently found in genomic neighborship with other resistance genes, transposable elements, and integrons, indicating their mobility. By contrast, the relative abundances of the more recently discovered variants dfrB9, dfrB10, and dfrB13 were significantly higher in freshwater than in wastewater microbiomes. Moreover, their direct neighborship with other resistance genes or markers of mobile genetic elements was significantly less likely. Our findings suggest that natural freshwater communities form a major reservoir of the recently discovered dfrB gene variants. Their proliferation and mobilization in response to the exposure of freshwater communities to selective TMP concentrations may promote the prevalence of high-level TMP resistance and thus limit the future effectiveness of antimicrobial therapies.
Alterations of auditory-evoked gamma oscillations are more pronounced than alterations of spontaneous power of gamma oscillation in early stages of schizophrenia
Authors: Tada Mariko , Kirihara Kenji , Koshiyama Daisuke , Nagai Tatsuya , Fujiouka Mao , Usui Kaori , Satomura Yoshihiro , Koike Shinsuke , Sawada Kingo , Matsuoka Jun , Morita Kentaro , Araki Tsuyoshi , Kasai Kiyoto 
Published: June 2023

AbstractSeveral animal models of schizophrenia and patients with chronic schizophrenia have shown increased spontaneous power of gamma oscillations. However, the most robust alterations of gamma oscillations in patients with schizophrenia are reduced auditory–oscillatory responses. We hypothesized that patients with early-stage schizophrenia would have increased spontaneous power of gamma oscillations and reduced auditory–oscillatory responses. This study included 77 participants, including 27 ultra-high-risk (UHR) individuals, 19 patients with recent-onset schizophrenia (ROS), and 31 healthy controls (HCs). The auditory steady-state response (ASSR) and spontaneous power of gamma oscillations measured as induced power during the ASSR period were calculated using electroencephalography during 40-Hz auditory click-trains. The ASSRs were lower in the UHR and ROS groups than in the HC group, whereas the spontaneous power of gamma oscillations in the UHR and ROS groups did not significantly differ from power in the HC group. Both early-latency (0–100 ms) and late-latency (300–400 ms) ASSRs were significantly reduced and negatively correlated with the spontaneous power of gamma oscillations in the ROS group. In contrast, UHR individuals exhibited reduced late-latency ASSR and a correlation between the unchanged early-latency ASSR and the spontaneous power of gamma oscillations. ASSR was positively correlated with the hallucinatory behavior score in the ROS group. Correlation patterns between the ASSR and spontaneous power of gamma oscillations differed between the UHR and ROS groups, suggesting that the neural dynamics involved in non-stimulus-locked/task modulation change with disease progression and may be disrupted after psychosis onset.
Caspase-1 affects chronic restraint stress-induced depression-like behaviors by modifying GABAergic dysfunction in the hippocampus
Authors: Li Mingxing , Sun Xuejiao , Wang Zongqin , Li Yi 
Published: June 2023

AbstractMajor depression disorder (MDD) is one of the most common psychiatric disorders and one of the leading causes of disability in worldwide. Both inflammation and GABAergic dysfunction have been implicated in the pathophysiology of MDD. Caspase-1, a classic inflammatory caspase, regulates AMPARs-mediated glutamatergic neurotransmission. However, the role of caspase-1 in chronic stress-induced GABAergic dysfunction remains largely unknown. In this study, we found that serum and hippocampal caspase-1-IL-1β levels increased significantly in chronic restraint stress (CRS) mice, and a significant negative correlation occurred between levels of caspase-1 and depression-like behaviors. Furthermore, CRS significantly decreased GAD67 mRNA levels and GABAergic neurotransmission accompanied by the reduction of GABA concentration, reduced the amplitude and frequency of mIPSCs inhibitory postsynaptic currents (mIPSCs) and the decreased surface expression of GABAARs γ2 subunit in the hippocampus. Genetic deficiency of caspase-1 not only blocked CRS-induced depression-like behaviors, but also alleviated CRS-induced impairments in GABAergic neurotransmission. Finally, reexpression of caspase-1 in the hippocampus of Caspase-1−/− mice increased susceptibility to stress-induced anxiety- and depression-like behaviors through inhibiting GAD67 expression and GABAARs-mediated synaptic transmission. Our study suggests that CRS dysregulates GABAergic neurotransmission via increasing the levels of caspase-1-mediated neuroinflammation in the hippocampus, ultimately leading to depression-like behaviors. This work illustrates that targeting caspase-1 may provide potential therapeutic benefits to stress-related GABAergic dysfunction in the pathogenesis of MDD.
Morphologic analysis of the foveal avascular zone for prediction of postoperative visual acuity in advanced idiopathic epiretinal membrane
Authors: Kim Gee-Hyun , Hwang Bo-Een , Chun Heejeong , Kim Joo Young , Kim Rae Young , Kim Mirinae , Park Young-Geun , Park Young-Hoon 
Published: June 2023

AbstractTo investigate the preoperative morphology of the foveal avascular zone (FAZ) for prediction of the postoperative visual acuity in advanced idiopathic epiretinal membrane (ERM). 28 patients (28 eyes) with unilateral idiopathic ERM who underwent pars plana vitrectomy with internal limiting membrane peeling were included. Superficial FAZ was measured preoperatively in both eyes using optical coherence tomography angiography. Area, perimeter, and circularity of FAZ were achieved, and the differences between the ERM eyes and the contralateral eyes were evaluated to analyze the degree of FAZ distortion in diseased eyes. The best-corrected visual acuity (BCVA) and central foveal thickness (CFT) were measured at baseline and more than 6 months after surgery. The correlations of the preoperative FAZ with BCVA and CFT were assessed. The FAZ in the eyes with ERM was significantly reduced, and the BCVA was significantly correlated with the FAZ area (FAZa) (P = 0.001) and the FAZ perimeter (FAZp) (P < 0.001) before surgery. LogMAR BCVA and CFT were significantly improved from 0.550 ± 0.221 to 0.354 ± 0.229 (P = 0.008), and from 524.393 ± 93.575 µm to 400.071 ± 75.979 µm (P < 0.001) after surgery. The preoperative FAZa and FAZp were significantly associated with letter score gain (P < 0.001, P < 0.001) and the postoperative final BCVA (P = 0.026, P = 0.006). The preoperative FAZp had correlation with ratio of postoperative to preoperative CFT (P = 0.016). The preoperative FAZp is a predictor of visual acuity and morphological prognosis after surgery in advanced idiopathic ERM.
A semi-empirical approach to calibrate simulation models for semiconductor devices
Authors: Jaiswal Rahul , Martínez-Ramón Manel , Busani Tito 
Published: June 2023

AbstractSemiconductor device optimization using computer-based prototyping techniques like simulation or machine learning digital twins can be time and resource efficient compared to the conventional strategy of iterating over device design variations by fabricating the actual device. Ideally, simulation models require perfect calibration of material parameters for the model to represent a particular semiconductor device. This calibration process itself can require characterization information of the device and its precursors and extensive expert knowledge of non characterizable parameters and their tuning. We propose a hybrid method to calibrate multiple simulation models for a device using minimal characterization data and machine learning-based prediction models. A photovoltaic device is chosen as the example for this technique where optical and electrical simulation models of an industrially manufactured silicon solar cell are calibrated and the simulated device performance is compared with the measurement data from the physical device.
Initial study on an expert system for spine diseases screening using inertial measurement unit
Authors: Pelc Mariusz , Vilimkova Kahankova Radana , Blaszczyszyn Monika , Mikolajewski Dariusz , Konieczny Mariusz , Khoma Volodymir , Bara Gregor , Zygarlicki Jaroslaw , Martinek Radek , Gupta Munish K. , Gorzelanczyk Edward Jacek , Pawłowski Mateusz , Czapiga Bogdan , Zygarlicka Malgorzata , Kawala-Sterniuk Aleksandra 
Published: June 2023

AbstractIn recent times, widely understood spine diseases have advanced to one of the most urgetn problems where quick diagnosis and treatment are needed. To diagnose its specifics (e.g. to decide whether this is a scoliosis or sagittal imbalance) and assess its extend, various kind of imaging diagnostic methods (such as X-Ray, CT, MRI scan or ST) are used. However, despite their common use, some may be regarded as (to a level) invasive methods and there are cases where there are contraindications to using them. Besides, which is even more of a problem, these are very expensive methods and whilst their use for pure diagnostic purposes is absolutely valid, then due to their cost, they cannot rather be considered as tools which would be equally valid for bad posture screening programs purposes. This paper provides an initial evaluation of the alternative approach to the spine diseases diagnostic/screening using inertial measurement unit and we propose policy-based computing as the core for the inference systems. Although the methodology presented herein is potentially applicable to a variety of spine diseases, in the nearest future we will focus specifically on sagittal imbalance detection.
Maternal exposure to childhood maltreatment and adverse birth outcomes
Authors: Keenan-Devlin Lauren S. , Borders Ann E. B. , Freedman Alexa , Miller Gregory E. , Grobman William , Entringer Sonja , Simhan Hyagriv , Wadhwa Pathik , Buss Claudia 
Published: June 2023

AbstractExposure to traumatic events during pregnancy may influence pregnancy and birth outcomes. Growing evidence suggests that exposure to traumatic events well before pregnancy, such as childhood maltreatment (CM), also may influence the course of pregnancy and risk of adverse birth outcomes. We aimed to estimate associations between maternal CM exposure and small-for-gestational-age birth (SGA) and preterm birth (PTB) in a diverse US sample, and to examine whether common CM-associated health and behavioral sequelae either moderate or mediate these associations. The Measurement of Maternal Stress (MOMS) Study was a prospective cohort study that enrolled 744 healthy English-speaking participants ≥ 18 years with a singleton pregnancy, who were < 21 weeks at enrollment, between 2013 and 2015. CM was measured via the Childhood Trauma Questionnaire (CTQ) and participants above the moderate/severe cut-off for any of the five childhood abuse and neglect scales were assigned to the CM-exposed group. Common CM-associated health (obesity, depressive symptoms, hypertensive disorders) and behavioral (substance use) sequelae were obtained from standardized questionnaires and medical records. The main outcomes included PTB (gestational age < 37 weeks at birth) and SGA (birthweight < 10%ile for gestational age) abstracted from the medical record. Multivariable logisitic regression was used to test associations between CM, sequeale, and birth outcomes, and both moderation and mediation by CM-related sequelae were tested. Data were available for 657/744 participants. Any CM exposure was reported by 32% of participants. Risk for SGA birth was 61% higher among those in the CM group compared to the non-CM group (14.1% vs. 7.6%), and each subsequent form of CM that an individual was exposed to corresponded with a 27% increased risk for SGA (aOR 1.27, 95% CI 1.05, 1.53). There was no significant association between CM and PTB (9.3% vs. 13.0%, aOR 1.07, 95% CI 0.58, 1.97). Of these sequelae only hypertensive disorders were associated with both CM and SGA and hypertensive disorders of pregnancy did not mediate the association between CM and SGA. Our findings indicate that maternal CM exposure is associated with increased risk for SGA birth and highlight the importance of investigating the mechanisms whereby childhood adversity sets the trajectory for long-term and intergenerational health issues.