bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors
Authors: Gonzalez Nicole , Rao Nina , Dean Michael , Lee Donghyuk , Hurson Amber N. , Baris Dalsu , Schwenn Molly , Johnson Alison , Prokunina-Olsson Ludmila , Friesen Melissa C. , Zhu Bin , Rothman Nathaniel , Silverman Debra T. , Koutros Stella 
Published: April 2023

<div>AbstractBackground:<p>Diesel exhaust is a complex mixture, including polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs (nitro-PAH), many of which are potent mutagens and possible bladder carcinogens. To explore the association between diesel exposure and bladder carcinogenesis, we examined the relationship between exposure and somatic mutations and mutational signatures in bladder tumors.</p>Methods:<p>Targeted sequencing was conducted in bladder tumors from the New England Bladder Cancer Study. Using data on 797 cases and 1,418 controls, two-stage polytomous logistic regression was used to evaluate etiologic heterogeneity between bladder cancer subtypes and quantitative, lifetime estimates of respirable elemental carbon (REC), a surrogate for diesel exposure. Poisson regression was used to evaluate associations between REC and mutational signatures.</p>Results:<p>We observed significant heterogeneity in the diesel-bladder cancer risk relationship, with a strong positive association among cases with high-grade, nonmuscle invasive <i>TP53</i>-mutated tumors compared with controls [OR<sub>Top Tertile vs.Unexposed</sub>, 4.8; 95% confidence interval (CI), 2.2–10.5; <i>P</i><sub>trend</sub> < 0.001; <i>P</i><sub>heterogeneity</sub> = 0.002]. In muscle-invasive tumors, we observed a positive association between diesel exposure and the nitro-PAH signatures of 1,6-dintropyrene (RR, 1.93; 95% CI, 1.28–2.92) and 3-nitrobenzoic acid (RR, 1.97; 95% CI, 1.33–2.92).</p>Conclusions:<p>The relationship between diesel exhaust and bladder cancer was heterogeneous based on the presence of <i>TP53</i> mutations in tumors, further supporting the link between PAH exposure and <i>TP53</i> mutations in carcinogenesis. Future studies that can identify nitro-PAH signatures in exposed tumors are warranted to add human data supporting the link between diesel and bladder cancer.</p>Impact:<p>This study provides additional insight into the etiology and possible mechanisms related to diesel exhaust-induced bladder cancer.</p></div>
Infarcts in a New Territory: Insights From the ESCAPE-NA1 Trial
Authors: Singh Nishita , Cimflova Petra , Ospel Johanna Maria , Kashani Nima , Marko Martha , Mayank Arnuv , Nogueira Raul G. , McTaggart Ryan A. , Demchuk Andrew M. , Poppe Alexandre Y. , Rempel Jeremy L. , Field Thalia S. , Dowlatshahi Dar , van Adel Brian , Swartz Richard H. , Shah Ruchir , Sauvageau Eric , Puetz Volker , Silver Frank L. , Campbell Bruce , Chapot René , Tymianski Michael , Goyal Mayank , Almekhlafi Mohammed A. , Hill Michael D. ,   on behalf of the ESCAPE-NA1 Trial Investigators
Published: April 2023

Background:
Infarct in a new territory (INT) is a known complication of endovascular stroke therapy. We assessed the incidence of INT, outcomes after INT, and the impact of concurrent treatments with intravenous thrombolysis and nerinetide.

Methods:
Data are from ESCAPE-NA1 trial (Safety and Efficacy of Nerinetide [NA-1] in Subjects Undergoing Endovascular Thrombectomy for Stroke), a multicenter, international randomized study that assessed the efficacy of intravenous nerinetide in subjects with acute ischemic stroke who underwent endovascular thrombectomy within 12 hours from onset. Concurrent treatment and outcomes were collected as part of the trial protocol. INTs were identified on core lab imaging review of follow-up brain imaging and defined by the presence of infarct in a new vascular territory, outside the baseline target occlusion(s) on follow-up brain imaging (computed tomography or magnetic resonance imaging). INTs were classified by maximum diameter (<2, 2–20, and >20 mm), number, and location. The association between INT and clinical outcomes (modified Rankin Scale and death) was assessed using standard descriptive techniques and adjusted estimates of effect were derived from Poisson regression models.

Results:
Among 1092 patients, 103 had INT (9.3%, median age 69.5 years, 49.5% females). There were no differences in baseline characteristics between those with versus without INT. Most INTs (91/103, 88.3%) were not associated with visible occlusions on angiography and 39 out of 103 (37.8%) were >20 mm in maximal diameter. The most common INT territory was the anterior cerebral artery (27.8%). Almost half of the INTs were multiple (46 subjects, 43.5%, range, 2–12). INT was associated with poorer outcomes as compared to no INT on the primary outcome of modified Rankin Scale score of 0 to 2 at 90 days (adjusted risk ratio, 0.71 [95% CI, 0.57–0.89]). Infarct volume in those with INT was greater by a median of 21 cc compared with those without, and there was a greater risk of death as compared to patients with no INT (adjusted risk ratio, 2.15 [95% CI, 1.48–3.13]).

Conclusions:
Infarcts in a new territory are common in individuals undergoing endovascular thrombectomy for acute ischemic stroke and are associated with poorer outcomes. Optimal therapeutic approaches, including technical strategies, to reduce INT represent a new target for incremental quality improvement of endovascular thrombectomy.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02930018.
Baltic Amber in Aššur. Forms and Significance of Amber Exchange between Europe and the Middle East, c.2000–1300 BC
Authors: Bunnefeld Jan-Heinrich , Becker Jörg , Martin Lutz , Pausewein Regine-Ricarda , Simon Stefan , Meller Harald 
Published: April 2023

Abstract
Under the large ziggurat of Aššur, Iraq, two Baltic amber beads were found in a foundation deposit dating to c.1800–1750 BC. Thereby, they represent one of the earliest and remotest evidence of this material. Its extreme rarity in the Mediterranean and the Middle East before c.1550 BC and its restriction there to high-ranking sites could be explained by the fact that the Únětice culture and the Wessex culture controlled the exchange of this raw material. Probably, the amber finds in the south result from a directional exchange with at most only a few intermediaries, as other finds in Europe and the Middle East from the early 2nd millennium BC also indicate. The amber finds may thus represent gifts from well-travelled persons from central or western Europe to the elites in the south. However, after c.1550 BC the picture changes, and it is perhaps possible to speak of trade through which amber became available in larger quantities in the Mediterranean and the Middle East.
Pilate Delivered Jesus to Them: Mark 15.15 in Ancient Versions and in Anti-Jewish Narratives
Authors: Visi Tamás 
Published: April 2023

Abstract
Some of the ancient manuscripts and versions of Mark 15.15 add the phrase ‘to them’ after the verb ‘[Pilate] delivered [Jesus]’, suggesting that Pilate delivered Jesus to the Jewish crowd who subsequently crucified him. This textual variant was well-established in the Syriac and Ethiopic traditions while it remained marginal in the Greek, Latin, and Coptic traditions. This pattern suggests that those translators and readers of the gospels who lived on the Eastern fringes or outside of the territory of the Roman empire were more inclined to accept the idea that Jesus had been executed by the Jewish mob (and not by the Roman soldiers) than those translators and readers who lived in the core territories of the empire. The Diatessaron most likely played an important role in disseminating this anti-Jewish narrative. The obliteration of historical memories about crucifixion as a Roman method of execution in late antiquity contributed to the formation of one of the most devastating anti-Jewish narratives of the ensuing centuries.
Compliance Standards in Continental Europe – Same, Same but Different!?
Authors: Michaelis Marcel , Mercuri Federico , Schoch Nicholas , Ollivier Alexis 
Published: April 2023

Abstract
This article deals with the ever-present hot topic of compliance and the related standards for a compliance management system (cms) in Continental Europe. It covers the existing legal regulations, the current case law, and the latest developments in Germany, France, and Italy with regard to the requirements for an effective cms. It also takes a look at the criteria that top management must fulfil in order to meet individual compliance requirements – and minimize the risk of liability. In addition, the authors also put the new iso standard 37301:2021 under the microscope and identify a common ground between the various national positions.
Sources of social support and clinical and functional evolution of people with schizophrenia
Authors: Vázquez Morejón Antonio J , León Rubio Jose María , Vázquez-Morejón Raquel 
Published: April 2023

Purpose: The impact of social support on comprehensive measures of results (clinical and functional) of the course of schizophrenia was studied, understood and evaluated as a multidimensional construct differentiating sources of support (family vs. nonfamily). Methods: One hundred fifty-two patients diagnosed with schizophrenia were assessed with the Mannheim Interview on Social Support (MISS) and the Social Functioning Scale (SFS). The hypotheses were explored in a prospective longitudinal design, using a causal correlational analysis for their evaluation by applying structural equation models. Results: The only explanatory factor of social functioning was Nonfamily social support, while the only explanatory factor of clinical result measurements was Family social support, observing a clearly differentiated impact of the different sources of support on the schizophrenia result measurements. It was also found that while Family social support explained 6.8% of the variance in the clinical result measurements, Nonfamily social support explained 13.7% of the variance in social functioning. Conclusion: The results confirmed the differential importance of social support variables (family vs. nonfamily) in the clinical and functional result measurements of people with schizophrenia.
Investigation of the microstructure, mechanical and wear performance of friction stir-processed AA6061-T6 plate reinforced with B4C particles surface composite
Authors: Abdelhady Saleh S , Elbadawi Rehab E , Zoalfakar Said H 
Published: April 2023

In this work, friction stir processing (FSP) was used to successfully embed boron carbide (B4C) particles into an aluminum matrix (AA6061-T6). Four specimens of aluminum 6061 composite reinforced with 4%, 6%, 8%, and 10% volume fraction of B4C were manufactured. The effects of B4C particles volume fraction on microstructure, mechanical and wear properties are investigated. The microstructural investigations demonstrated that a rise in the volume % of reinforcement greatly decreased the matrix grain size. The manufactured AA6061-T6 loaded with B4C surface composites demonstrated homogeneous B4C particle dispersion, with no significant particle clustering in the stir zone. In addition, it was established that increasing the volume fraction of B4C particles promoted grain refinement, increased hardness, and tensile strength. X-ray diffraction (XRD) was used to identify the reinforcement dispersion. For AA6061-T6 with 10% B4C particles, a maximum hardness value of 163 HV was obtained in the stir zone. Maximum yield strength of 165 MPa and ultimate tensile strength of 220 MPa were attained by AA6061-T6 with 10% B4C particles, which is an improvement of 21% over the specimen FSP without reinforcement. The strengthening of the grain refining was attributed for the increase in hardness and strength. The ductility was reduced by the incorporation of more B4C particles. Comparing the surface composite loaded with B4C to unreinforced friction stir processing and AA6061-T6 as received, it demonstrated superior wear resistance.
Safety and Feasibility of Hypnosis-Induced Sleep Endoscopy in Obstructive Sleep Apnea Patients.
Authors: Bobin Francois , Garreau Céline , Lechien Jerome R. 
Published: April 2023

Background Hypnosis was never used in sleep endoscopy assessment of obstructive sleep apnea syndrome (OSAS). The aim of the study was to assess the feasibility, safety, and patient satisfaction of hypnosis-induced sleep endoscopy (HISE). Methods From January to July 2021, 24 adults with moderate-to-severe OSAS at the polysomnography were included in the HISE protocol. The following outcomes were evaluated by the otolaryngologist and the hypnotherapist: safety, feasibility, and performance. The patient outcomes were assessed through a patient-reported outcome questionnaire assessing hypnosis acceptance, stress, anxiety, nasofibroscopy examination pain, and discomfort. Results Twenty-three patients completed the evaluations (16 males). The mean age of patients was 50.8 years. The nasofibroscopy was well-tolerated with low levels of stress during the HISE. Otolaryngologist adequately completed the VOTE scoring in 22 patients (95.7%). Hypnosis was ineffective in one patient because he felt pain during the nasofibroscopy procedure due to an important septal deviation. The hypnotherapist reported adequate satisfaction outcomes, with better results for trance compliance compared to other steps. There were no adverse effects or complications. The percentage of snoring was negatively associated with the level of consciousness during hypnosis (p = 0.012). The easiness of nasofibroscopy was positively associated with the levels of muscle relaxation (p = 0.036) and consciousness ( P = 0.002). Conclusion HISE is an effective alternative approach for the work-up of OSAS. Future controlled studies are needed to compare HISE with drug-induced sleep endoscopy and assess the cost-effective outcomes of both approaches.
Research Landscape on Student Suicide: A Bibliometric and Visual Analysis of 62 Years (1959-2021)
Authors: Srivastava Khusboo , Saxena Ankita 
Published: April 2023

Background: To guide and provide orientation to research on student suicide, this study aimed to analyze the research status on student suicide with the help of bibliometric analysis. Utilising bibliometric methodology, this study complements existing literature by giving a comprehensive, reliable thematic representation of this topic. Method: A Scopus search was done and all published research papers were reviewed. A total of 187 papers published between 1959 and 2021 were analyzed. We identified the most influential journals in this field, the most prolific nations and institutions, as well as the years with the most publications, the most cited papers, notable authors, and most researched areas, It was followed by use of the VOSviewer software (version 1.6.18) to construct and visualize the bibliometric networks like co-authorship network map, inter-country co-authorship network map, and keywords co-occurrences network maps. Results: The analysis reveals the current research trend where the number of publications on ‘student suicide’ reflects an overall upward trend over the years, suggesting that research on student suicidology is fast evolving but the pace is slow. The maximum publications were in the year 2020. The United States made the largest contribution (n = 85). The most productive institution was the University of Rochester, New York (n = 10). Allan J Schwartz was the most prolific author, with nine research papers. Journal of College Student Psychotherapy (n = 13) was the journal and Medicine (n = 118) was the discipline with the highest number of publications. Conclusion: The study potentially has important implications for designing more comprehensive screening and assessment tools for suicide risk. Future work should pay more attention to developing effective intervention programs for students. The results also highlight the need for more research work on student suicidology. More research in this area is needed to create awareness among students. Consequently, this study can be a big critique and torch bearer at the same time.
Support Needs in Carers of People With Parkinson’s From Early to Later Stages: A Qualitative Study With 36 Carers in 11 European Countries
Authors: Merritt Rowena K. , Hotham Sarah , Schrag Anette 
Published: April 2023

Background Parkinson’s Disease (PD) is associated with considerable carer burden, but there has been little qualitative research on the support needs of carers of People with Parkinson’s (PwP). Methods Semi-structured in-depth interviews with carers of PwP in 11 European countries. Results Interviews with 36 carers of PwP were analysed. At the time of diagnosis, carers often felt that they had a role in helping get a diagnosis and then in dealing with the impact of the diagnosis on the family. Information on medication was seen as particularly important for carers, and many of the carers felt that their informational needs differed from that of the PwPs. Many of the carers also felt that they needed to be present at all appointments to request referrals or ask for medication changes. Carers of those in the later stages of the disease often reported feeling isolated and not having any time for themselves. Conclusions The involvement of carers should be addressed more actively in the management of Parkinson’s.
Electroacupuncture of the cymba concha alleviates p-chlorophenylalanine-induced insomnia in mice
Authors: Zhang Fenyan , Zhang Xiaoming , Peng Qi , Tang Ling 
Published: April 2023

Objective: Insomnia is the most common sleep disorder and is often comorbid with mental and physical diseases. The present study was designed to investigate the hypnotic effect of electroacupuncture (EA) of the cymba concha to stimulate the auricular branch of the vagus nerve (ABVN). Methods: Mice were intraperitoneally injected with p-chlorophenylalanine (PCPA, 300 mg/kg·d) for 2 days to induce insomnia and subsequently received EA or manual acupuncture (MA) of the cymba concha for 30 min once daily for 5 consecutive days, or no treatment. The phenobarbital-induced sleep test was used to analyze the hypnotic effects and the open field test was used to analyze the locomotor activities and anxiolytic effects of EA/MA of the cymba concha. In addition, the levels of gamma-aminobutyric acid (GABA) and glutamate (Glu) in the hypothalamus and peripheral blood were determined by enzyme-linked immunosorbent assay (ELISA). Results: PCPA injection significantly decreased sleep duration, increased sleep latency and induced anxiety-like behaviors in mice. In PCPA-insulted mice, EA of the cymba concha improved the sleep disturbance by significantly prolonging sleep duration, while no change in sleep latency was observed. Moreover, EA of the cymba concha improved PCPA-induced anxiety-like behaviors without decreasing locomotor activities in the open field test. EA of the cymba concha increased the level of GABA in the hypothalamus and peripheral blood, while Glu concentrations remained unchanged. Conclusion: These findings indicate that EA of the region innervated by the ABVN upregulates GABA levels in the hypothalamus and ameliorates the symptoms of insomnia and anxiety, suggesting that EA of the cymba concha might have potential value as an intervention for insomnia.
Comparison of the Autopsy and Placental Findings in Second vs Third Trimester Stillbirth
Authors: Manjee Kiran , Price Erica , Ernst Linda M. 
Published: April 2023

Background: The pathology of second trimester fetal loss is not well-characterized due to lack of comprehensive autopsy studies. The purpose of this study is to compare autopsy pathology of second trimester and third trimester stillbirth. Methods: In this retrospective cohort study, fetal autopsies performed in-house with complete placental examination were included. From autopsy reports, maternal demographics, gestational age, sex, body and placental weight, congenital anomalies, and cause of death (COD) were obtained. Immediate COD was coded “probable” or “possible” according to Initial Causes of Fetal Death (INCODE). Results: Among 68 second trimester and 54 third trimester fetal autopsies, at least 1 probable COD was identified in 59/68 (87%) second trimester and 44/54 (81%) third trimester cases. 42/68 (62%) second trimester and 28/54 (52%) third trimester fetuses had probable COD secondary to placental pathology. Among placental causes, 29/42 (69%) second trimester and 14/28 (50%) third trimester stillbirths were related to compromised fetal microcirculation with umbilical cord abnormality. Conclusions: Among stillborn first and second trimester fetuses who undergo autopsy, the most prevalent COD is pathologic placental conditions, particularly those associated with umbilical cord obstruction. This study stresses the importance of placenta examination for establishing COD in both second and third trimester fetuses.
Measures of Fetal Growth and Cardiac Structure in Stillbirths With Placental Maternal Vascular Malperfusion: Evidence for Heart Weight Sparing and Structural Cardiac Alterations in Humans
Authors: Freedman Alexa A. , Price Erica , Franklin Andrew , Ernst Linda M. 
Published: April 2023

Background: Placental maternal vascular malperfusion (MVM) is associated with fetal growth restriction (FGR). While FGR increases the risk of cardiovascular disease, the impact of MVM on fetal cardiac structure is understudied. Methods: We utilized a cohort of autopsied stillbirths; 29 with MVM as the cause of death and 21 with a cause of death unrelated to MVM. Fetal and organ weights and heart measurements were standardized by gestational age and compared between MVM and non-MVM stillbirths. Differences in standardized fetal organ and cardiac measures as compared to standardized fetal body weight were calculated to account for body size. Results: MVM stillbirths had smaller organ and heart weights than non-MVM stillbirths; however, after accounting for gestational age, heart weight was the least affected among all organs. In an analysis of organ weights relative to body size, heart weights were 0.31 standard deviations (SD) larger than expected relative to body weight (95% CI: 0.04, 0.57). Right and left ventricle thicknesses and mitral valve circumference were also larger than expected relative to body weight. Conclusion: Stillbirth due to MVM was associated with relative sparing of heart weight and other heart measurements. The significance of these findings in liveborn infants needs further study.
Treatment Court Family Nights: An Accessible and Adaptable Support for Families Engaging in Recovery
Authors: Palombi Laura , Van Deelen Anna , Hawn Andrew , Kosobuski Lucas , Katras Mary Jo 
Published: April 2023

Introduction: While public health measures including physical distancing and stay-at-home orders have clear benefits in COVID-19 mitigation and prevention, they have provided unique challenges for individuals with substance use disorder (SUD), including Treatment Court (TC) participants. Methods: This study involved a qualitative evaluation of TC Family Nights; one series of Family Nights was conducted before the COVID-19 pandemic and the second series was adapted and held remotely due to COVID-19 distancing requirements. Results: Several important themes emerged, including general positive experiences, accessible session logistics, naloxone training, attention to stigma, building recovery capital, group engagement, social interaction, and community action. These themes will help inform future SUD recovery education. Conclusion: Online recovery support events provide a new model for courts and recovery organizations that seek multiple ways to provide connection and support for their participants and families during times when accessibility is prioritized, in-person activities are discouraged, and in resource-sparse and geographically isolated communities.