bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benefits of a 12-Week Non-Drug “Brain Fitness Program” for Patients with Attention-Deficit/Hyperactive Disorder, Post-Concussion Syndrome, or Memory Loss
Authors: Fotuhi Majid , Khorrami Noah D. , Raji Cyrus A. 
Published: June 2023

Background: Non-pharmacologic interventions can potentially improve cognitive function, sleep, and/or mood in patients with attention-deficit/hyperactive disorder (ADHD), post-concussion syndrome (PCS), or memory loss. Objective: We evaluated the benefits of a brain rehabilitation program in an outpatient neurology practice that consists of targeted cognitive training, lifestyle coaching, and electroencephalography (EEG)-based neurofeedback, twice weekly (90 minutes each), for 12 weeks. Methods: 223 child and adult patients were included: 71 patients with ADHD, 88 with PCS, and 64 with memory loss (mild cognitive impairment or subjective cognitive decline). Patients underwent a complete neurocognitive evaluation, including tests for Verbal Memory, Complex Attention, Processing Speed, Executive Functioning, and Neurocognition Index. They completed questionnaires about sleep, mood, diet, exercise, anxiety levels, and depression—as well as underwent quantitative EEG—at the beginning and the end of the program. Results: Pre-post test score comparison demonstrated that all patient subgroups experienced statistically significant improvements on most measures, especially the PCS subgroup, which experienced significant score improvement on all measures tested ( p≤0.0011; d z≥0.36). After completing the program, 60% to 90% of patients scored higher on cognitive tests and reported having fewer cognitive and emotional symptoms. The largest effect size for pre-post score change was improved executive functioning in all subgroups (ADHD d z= 0.86; PCS d z= 0.83; memory d z= 1.09). Conclusion: This study demonstrates that a multimodal brain rehabilitation program can have benefits for patients with ADHD, PCS, or memory loss and supports further clinical trials in this field.
Corak dan Penafsiran Ayat Mawaris dalam Kitab Tafsir Marah Labid Karya Syekh Nawawi Al-Bantani
Authors: Tri Oktafia .Z Zeti Isra 
Published: June 2023

This article discusses the verses of the Qur'an, which is one of the efforts to understand the existing studies. Discussing the right of inheritance where this right of inheritance becomes inheritance property for heirs, the division of inheritance is the division of inheritance when someone has died, who gets the right of inheritance is that there are criteria for each reason what has been explained in the Quran and legal requirements in Islam, the division of property that gets is certain people such as parents, The side of the father, the side of the mother and many more criteria that get and become heirs. and whoever gets the inheritance, this is already explained in the Qur'an in surah An-nisa in verses 11-12 and in verse 176 which is interpreted in the book of tafsir Marah Labid. Written by Sheikh Nawawi Al-Banthani. And the interpretation of the book of Marah Labid uses the method of interpretation of tahlili and ijmali and is patterned interpretation.
Beyond Building: Designing Sustainability For Humans
Authors: Cairns-Spicer Mitchell Zayne 
Published: June 2023

<p>Advancements in building design and technology have greatly lessened the environmental impact of cities and homes—however architecture encompasses much more than building performance. Contemporary sustainable design removes the burden of behaving in a sustainable manner from the occupant and hides it behind high efficiency equipment and passive design strategies. This approach to design makes up for irresponsible human behavior, it mitigates the outcome of a behavioral problem. This thesis explores how architecture may be able to step beyond autonomous efficiency and better engage its occupants with their environmental impact and the resources they consume. It explores how architecture may be able to bring legibility to systems of resource consumption that are currently obfuscated from building occupants and ultimately advocate a mode of use in servitude of sustainable goals. </p>
Self-Regulated Architecture: Artificially Enhanced Environments
Authors: Guzman-Romero Andres 
Published: June 2023

<p>Notions of humanism permeate architecture. Since the enlightenment, humanism has been the central philosophical and theoretical discourse informing architecture. However, the conditions in which architecture serves as a mediating agent have been significantly intensified over the past few decades by technological advancements. The impact of these technologies challenges the conceptualization of the building as a static and neutral device. Instead, the building becomes a self-regulating organism with the capability of interacting with the user and the environment, blurring the line between the organic and inorganic. This design research explores the uncanny as an architectural device capable of producing an aesthetic affect beyond the traditional humanist framework. The design investigation will apply aspects of form, order, and scale to find an alternate approach towards the architectural object. Such modes of operation aim to reveal posthumanist relations between self and technology by intensifying the aesthetic engagement between the user and the building. </p>
Late Diagnosis of Turner Syndrome – Rare Genetic Disease : A Case Report
Authors: Gosal Astri Amelia , Artati Ratna Dewi 
Published: June 2023

Turner syndrome (TS) is a rare genetic disease that occurs only in girls and is the result of the complete or partial absence of the X chromosome. TS has often delayed diagnosis in late childhood or adolescent age and is rarely identified during the neonatal period. The clinical features are primary amenorrhea, short stature, infertility, and characteristic dysmorphic features. Late diagnosis is the main problem because early detection and appropriate management can improve the final height, sexual health and psychological development of patients. We report a case of turner syndrome in a 16-years and 4-months old female adolescent. The patient had specific clinical features of turner syndrome such as amenorrhea, absence of secondary sex growth and posture short stature since 14 years old. This case was confirmed from anamnesis, physical examination and chromosomal analysis, which demonstrated a gene karyotype of 45, X monosomy.
Job Insecurity, Grit and Work Engagement in The Hospitality Industry During Covid-19
Authors: Meiliyandrie Indah Wardani Laila , Oktavia Agustin Werinusa Jesi , Istiqomah Istiqomah , Reevany Bustami Mohammad 
Published: June 2023

This research was conducted to identify the influence of job insecurity and grit toward work engagement on 276 hospitality employees during the COVID-19 pandemic. It consisted of 81 male respondents and 195 female respondents. The sampling technique used was the purposive sampling technique, which has specific criteria. Those criteria are hospitality workers in hotels, the food and beverage industry, administration, marketing, travel, transportation, and housekeeping companies in Jakarta. This research used three measurement tools, namely, the Utrecht Work Engagement Scale (17 items; a = .856), the Job Insecurity Scale (9 items; a = .887), and the Grit Scale (12 items; a = .797). Multiple linear regression was used as a data analysis method. The findings indicated that during the COVID-19 pandemic, job insecurity and grit had an impact on the level of work engagement among hospitality employees. Job insecurity and grit both significantly affect how motivated people are at work in the hospitality industry. Employees’ job insecurity and grit have a positive relationship that can raise the value of work engagement. Therefore, decreasing job insecurity calls for high levels of grit and work engagement to keep employee positions within the organization. The strongest correlation was found between the dimensions of grit (perseverance of effort) and work engagement (dedication). Unlike this research, which was conducted on hospitality workers, the previous research was conducted on general workers. They expected the best performance, including maintaining a friendly smile and offering the best service in all circumstances while the pandemic was ongoing.
Chromosomal engineering of inducible isopropanol- butanol-ethanol production in Clostridium acetobutylicum
Authors: Omorotionmwan Bunmi B. , Wang Hengzheng , Baker Jonathan P. , Gizynski Krzysztof , Yoo Minyeong , Akaluka Cynthia , Zhang Ying , Minton Nigel P. 
Published: June 2023

The use of environmentally damaging petrochemical feedstocks can be displaced by fermentation processes based on engineered microbial chassis that recycle biomass-derived carbon into chemicals and fuels. The stable retention of introduced genes, designed to extend product range and/or increase productivity, is essential. Accordingly, we have created multiply marked auxotrophic strains of Clostridium acetobutylicum that provide distinct loci (pyrE, argH, purD, pheA) at which heterologous genes can be rapidly integrated using allele-coupled exchange (ACE). For each locus, ACE-mediated insertion is conveniently selected on the basis of the restoration of prototrophy on minimal media. The Clostridioides difficile gene (tcdR) encoding an orthogonal sigma factor (TcdR) was integrated at the pyrE locus under the control of the lactose-inducible, bgaR::PbgaL promoter to allow the simultaneous control of genes/operons inserted at other disparate loci (purD and pheA) that had been placed under the control of the PtcdB promoter. In control experiments, dose-dependent expression of a catP reporter gene was observed with increasing lactose concentration. At the highest doses tested (10 mM) the level of expression was over 10-fold higher than if catP was placed directly under the control of bgaR::PbgaL and over 2-fold greater than achieved using the strong Pfdx promoter of the Clostridium sporogenes ferredoxin gene. The utility of the system was demonstrated in the production of isopropanol by the C. acetobutylicum strain carrying an integrated copy of tcdR following the insertion of a synthetic acetone operon (ctfA/B, adc) at the purD locus and a gene (sadh) encoding a secondary dehydrogenase at pheA. Lactose induction (10 mM) resulted in the production of 4.4 g/L isopropanol and 19.8 g/L Isopropanol-Butanol-Ethanol mixture.
Clinical outcomes of chronic heart failure patients with unsuppressed sleep apnea by positive airway pressure therapy
Authors: Naito Ryo , Kasai Takatoshi , Tomita Yasuhiro , Kasagi Satoshi , Narui Koji , Momomura Shin-Ichi 
Published: June 2023

IntroductionHeart failure (HF) is an advanced stage of cardiac disease and is associated with a high rate of mortality. Previous studies have shown that sleep apnea (SA) is associated with a poor prognosis in HF patients. Beneficial effects of PAP therapy that is effective on reducing SA on cardiovascular events, were not yet established. However, a large-scale clinical trial reported that patients with central SA (CSA) which was not effectively suppressed by continuous positive airway pressure (CPAP) revealed poor prognosis. We hypothesize that unsuppressed SA by CPAP is associated with negative consequences in patients with HF and SA, including either obstructive SA (OSA) or CSA.MethodsThis was a retrospective observational study. Patients with stable HF, defined as left ventricular ejection fraction of ≤50%; New York Heart Association class ≥ II; and SA [apnea–hypopnea index (AHI) of ≥15/h on overnight polysomnography], treated with CPAP therapy for 1 month and performed sleep study with CPAP were enrolled. The patients were classified into two groups according to AHI on CPAP (suppressed group: residual AHI ≥ 15/h; and unsuppressed group: residual AHI &lt; 15/h). The primary endpoint was a composite of all-cause death and hospitalization for HF.ResultsOverall, data of 111 patients including 27 patients with unsuppressed SA, were analyzed. The cumulative event-free survival rates were lower in the unsuppressed group during a period of 36.6 months. A multivariate Cox proportional hazard model showed that the unsuppressed group was associated with an increased risk for clinical outcomes (hazard ratio 2.30, 95% confidence interval 1.21–4.38, p = 0.011).ConclusionOur study suggested that in patients with HF and SA including either OSA or CSA, presence of unsuppressed SA even on CPAP was associated with worse prognosis as compared to those with suppressed SA by CPAP.
Effectiveness, safety, and costs of thromboprophylaxis with enoxaparin or unfractionated heparin in inpatients with obesity
Authors: Amin Alpesh , Kartashov Alex , Ngai Wilson , Steele Kevin , Rosenthal Ning 
Published: June 2023

BackgroundObesity is a frequent and significant risk factor for venous thromboembolism (VTE) among hospitalized adults. Pharmacologic thromboprophylaxis can help prevent VTE, but real-world effectiveness, safety, and costs among inpatients with obesity are unknown.ObjectiveThis study aims to compare clinical and economic outcomes among adult medical inpatients with obesity who received thromboprophylaxis with enoxaparin or unfractionated heparin (UFH).MethodsA retrospective cohort study was performed using the PINC AI™ Healthcare Database, which covers more than 850 hospitals in the United States. Patients included were ≥18 years old, had a primary or secondary discharge diagnosis of obesity [International Classification of Diseases (ICD)-9 diagnosis codes 278.01, 278.02, and 278.03; ICD-10 diagnosis codes E66.0x, E66.1, E66.2, E66.8, and E66.9], received ≥1 thromboprophylactic dose of enoxaparin (≤40 mg/day) or UFH (≤15,000 IU/day) during the index hospitalization, stayed ≥6 days in the hospital, and were discharged between 01 January 2010, and 30 September 2016. We excluded surgical patients, patients with pre-existing VTE, and those who received higher (treatment-level) doses or multiple types of anticoagulants. Multivariable regression models were constructed to compare enoxaparin with UFH based on the incidence of VTE, pulmonary embolism (PE)­­­­­­­­–related mortality, overall in-hospital mortality, major bleeding, treatment costs, and total hospitalization costs during the index hospitalization and the 90 days after index discharge (readmission period).ResultsAmong 67,193 inpatients who met the selection criteria, 44,367 (66%) and 22,826 (34%) received enoxaparin and UFH, respectively, during their index hospitalization. Demographic, visit-related, clinical, and hospital characteristics differed significantly between groups. Enoxaparin during index hospitalization was associated with 29%, 73%, 30%, and 39% decreases in the adjusted odds of VTE, PE-related mortality, in-hospital mortality, and major bleeding, respectively, compared with UFH (all p &lt; 0.002). Compared with UFH, enoxaparin was associated with significantly lower total hospitalization costs during the index hospitalization and readmission periods.ConclusionsAmong adult inpatients with obesity, primary thromboprophylaxis with enoxaparin compared with UFH was associated with significantly lower risks of in-hospital VTE, major bleeding, PE-related mortality, overall in-hospital mortality, and hospitalization costs.
Iodine deficiency and real-life supplementation ineffectiveness in Polish pregnant women and its impact on thyroid metabolism
Authors: Filipowicz Dorota , Szczepanek-Parulska Ewelina , Mikulska-Sauermann Aniceta A. , Karaźniewicz-Łada Marta , Główka Franciszek K. , Szymanowski Krzysztof , Ołtarzewski Mariusz , Schomburg Lutz , Ruchała Marek 
Published: June 2023

IntroductionIodine is a pivotal component of thyroid hormones, and its deficiency leads to negative pregnancy outcomes. Therefore, during gestation, additional iodine supplementation is recommended.ObjectivesBy evaluating a group of women from western Poland, the study updated on iodine status during pregnancy and the effectiveness of iodine supplementation in relation to the maternal and neonatal thyroid function.Patients and methodsA total of 91 women were recruited before the delivery between 2019 and 2021. During the medical interview, the patients declared their dietary supplements intake. Thyroid parameters (TSH, ft3, ft4, a-TPO, a-Tg, and TRAb) were measured in the serum of mothers and in the cord blood of newborns after birth. Urinary iodine concentration (UIC) and urine/creatinine (UIC/crea) ratio were assessed in single urine samples using a validated high-performance liquid chromatography with ultraviolet detection (HPLC-UV). Neonatal TSH screening from dried blood spot was analyzed.ResultsPregnant women showed a median (interquartile range) UIC of 106 (69–156) µg/liter and UIC/crea ratio of 104 (62–221) µg/g, whereas approximately 20% had UIC/crea below 50 µg/g, indicating iodine deficiency. The iodine supplementation ratio was 68%. No significant differences in UIC, UIC/crea and thyroid parameters were found between iodine supplemented and non-supplemented groups; however, the highest ioduria was detected when iodine was supplemented in addition to levothyroxine in comparison with both substances administered separately. Patients with UIC/crea within 150–249 µg/g demonstrated the lowest TSH and a-TPO levels. Screening TSH was above 5 mIU/liter in 6% of children.ConclusionsDespite the national salt iodization and the recommendation to supplement iodine during gestation, the status of the abovementioned microelement and real-life intake revealed the ineffectiveness of the current iodine-deficiency prophylaxis model in pregnancy.
Identification and analysis of cellular senescence-associated signatures in diabetic kidney disease by integrated bioinformatics analysis and machine learning
Authors: Luo Yuanyuan , Zhang Lingxiao , Zhao Tongfeng 
Published: June 2023

BackgroundDiabetic kidney disease (DKD) is a common complication of diabetes that is clinically characterized by progressive albuminuria due to glomerular destruction. The etiology of DKD is multifactorial, and numerous studies have demonstrated that cellular senescence plays a significant role in its pathogenesis, but the specific mechanism requires further investigation.MethodsThis study utilized 5 datasets comprising 144 renal samples from the Gene Expression Omnibus (GEO) database. We obtained cellular senescence-related pathways from the Molecular Signatures Database and evaluated the activity of senescence pathways in DKD patients using the Gene Set Enrichment Analysis (GSEA) algorithm. Furthermore, we identified module genes related to cellular senescence pathways through Weighted Gene Co-Expression Network Analysis (WGCNA) algorithm and used machine learning algorithms to screen for hub genes related to senescence. Subsequently, we constructed a cellular senescence-related signature (SRS) risk score based on hub genes using the Least Absolute Shrinkage and Selection Operator (LASSO), and verified mRNA levels of hub genes by RT-PCR in vivo. Finally, we validated the relationship between the SRS risk score and kidney function, as well as their association with mitochondrial function and immune infiltration.ResultsThe activity of cellular senescence-related pathways was found to be elevated among DKD patients. Based on 5 hub genes (LIMA1, ZFP36, FOS, IGFBP6, CKB), a cellular senescence-related signature (SRS) was constructed and validated as a risk factor for renal function decline in DKD patients. Notably, patients with high SRS risk scores exhibited extensive inhibition of mitochondrial pathways and upregulation of immune cell infiltration.ConclusionCollectively, our findings demonstrated that cellular senescence is involved in the process of DKD, providing a novel strategy for treating DKD.
A shared genetic contribution to osteoarthritis and COVID-19 outcomes: a large-scale genome-wide cross-trait analysis
Authors: Huang Yi-Xuan , Tian Tian , Huang Ji-Xiang , Wang Jing , Sui Cong , Ni Jing 
Published: June 2023

BackgroundPatients with osteoarthritis (OA) are exposed to an increased risk of adverse outcomes of COVID-19, and they tend to experience disruption in access to healthcare services and exercise facilities. However, a deep understanding of this comorbidity phenomenon and the underlying genetic architecture of the two diseases is still unclear. In this study, we aimed to untangle the relationship between OA and COVID-19 outcomes by conducting a large-scale genome-wide cross-trait analysis.MethodsGenetic correlation and causal relationships between OA and COVID-19 outcomes (critical COVID-19, COVID-19 hospitalization, and COVID-19 infection) were estimated by linkage disequilibrium score regression and Mendelian Randomization approaches. We further applied Multi-Trait Analysis of GWAS and colocalization analysis to identify putative functional genes associated with both OA and COVID-19 outcomes.ResultsSignificant positive genetic correlations between OA susceptibility and both critical COVID-19 (rg=0.266, P=0.0097) and COVID-19 hospitalization (rg=0.361, P=0.0006) were detected. However, there was no evidence to support causal genetic relationships between OA and critical COVID-19 (OR=1.17[1.00-1.36], P=0.049) or OA and COVID-19 hospitalization OR=1.08[0.97-1.20], P=0.143). These results were robustly consistent after the removal of obesity-related single nucleotide polymorphisms (SNPs). Moreover, we identified a strong association signal located near the FYCO1 gene (lead SNPs: rs71325101 for critical COVID-19, Pmeta=1.02×10-34; rs13079478 for COVID-19 hospitalization, Pmeta=1.09×10-25).ConclusionOur findings further confirmed the comorbidity of OA and COVID-19 severity, but indicate a non-causal impact of OA on COVID-19 outcomes. The study offers an instructive perspective that OA patients did not generate negative COVID-19 outcomes during the pandemic in a causal way. Further clinical guidance can be formulated to enhance the quality of self-management in vulnerable OA patients.