bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Pilot Study Conducted at a Tertiary Cancer Care Center, Evaluating the Serum Asparaginase Activity in Children Suffering from Acute Lymphoblastic Leukemia after the Administration of Biosimilar Pegaspargase
Authors: Venkatagiri Archana Melavarige , Bhat Vasudeva K. , Asok Arjun , Prabhu Krishnananda 
Published: September 2023

Abstract
Introduction L-asparaginase is considered to be the most important component in the treatment of acute lymphoblastic leukemia (ALL). Intensifying the use of L-asparaginase during treatment for ALL has resulted in a significant rise in the percentage of children and adolescents who are cured of the disease. Asparaginase trough activity more than or equal to 100 IU/L on day 7 has been found to be the desired activity level in all childhood leukemia patients.
Objectives Due to the paucity of data on biosimilar pegaspargase in the upfront setting, we planned this prospective pilot study to evaluate the levels of serum asparaginase activity (SAA) after biosimilar pegaspargase infusion.
Materials and Methods It is a prospective, single-center, pilot study of 10 pediatric ALL patients for the duration of 6 months. All children less than 18 years with ALL on treatment with curative intent and receiving pegaspargase and who provided informed consent were included in this study. The enzymatic spectrophotometric method was used to determine SAA, and it was measured on the 7th and 14th days after the first dosage of pegaspargase-asparaginase, as well as on the 14th day after the second dose of pegaspargase-asparaginase, while toxicity was charted according to Common Terminology Criteria for Adverse Events (CTCAE) version 4.0.
Results From 10 patients with a median age of 5.5 years, a grand total of 29 samples were taken for analysis. Children who received pegaspargase had either B-ALL or T-ALL. After the first dose, mean ± SD (standard deviation), SAA levels at day 7 was 131.3 ± 38 IU/L and at Day 14 was 94.8 ± 8 IU/L. After the second dose, mean ± SD SAA level at day 14 was 86.1 ± 15 IU/L. No patient had clinical hypersensitivity reaction and no patient reported any asparaginase-related toxicity. One patient died due to sepsis, infection with multidrug-resistant gram-negative bacteria.
Conclusions Biosimilar pegaspargase maintained good SAA levels 7 and 14 days after infusion.
Drug Trial Registration: Clinical Trial Registry of India vide reference CTRI/2021/08/036033 and available at https://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=59285&EncHid=&userName=
Probing shock dynamics inside micro-wire targets after high-intensity laser irradiation using small angle x-ray scattering of a free-electron laser
Authors: Kluge Thomas , Bussmann Michael , Galtier Eric , Glenzer Siegfried , Grenzer Jörg , Gutt Christian , Hartley Nicholas J , Huang Lingen , Garcia Alejandro Laso , Lee Hae Ja , McBride Emma E , Metzkes-Ng Josefine , Nakatsutsumi Motoaki , Nam Inhyuk , Pelka Alexander , Prencipe Irene , Randolph Lisa , Rehwald Martin , Rödel Christian , Rödel Melanie , Toncian Toma , Yang Long , Zeil Karl , Schramm Ulrich , Cowan Thomas E 
Published: September 2023

Abstract
In this paper, we present an experiment that explores the plasma dynamics of a

7
μ

m

diameter carbon wire after being irradiated with a near-relativistic-intensity short pulse laser. Using an x-ray free electron laser pulse to measure the small angle x-ray scattering signal, we observe that the scattering surface is bent and prone to instability over tens of picoseconds. The dynamics of this process are consistent with the presence of a sharp, propagating shock front inside the wire, moving at a speed close to the hole boring velocity or that expected from a thermal shock at a few tens of Mbar.
Multi-agent blind quantum computation without universal cluster states
Authors: Cao Shuxiang 
Published: September 2023

Abstract
Blind quantum computation (BQC) protocols enable quantum algorithms to be executed on third-party quantum agents while keeping the data and algorithm confidential. The previous proposals for measurement-based BQC require preparing a highly entangled cluster state. In this paper, we show that such a requirement is not necessary. Our protocol only requires pre-shared Bell pairs between delegated quantum agents, and there is no requirement for any classical or quantum information exchange between agents during the execution. Our proposal requires fewer quantum resources than previous proposals by eliminating the need for a universal cluster state.
Constraining primordial magnetic fields with line-intensity mapping
Authors: Adi Tal , Libanore Sarah , Cruz Hector Afonso G. , Kovetz Ely D. 
Published: September 2023

AbstractPrimordial magnetic fields (PMFs) offer a compelling explanation for the origin of observed magnetic fields, especially on extragalactic scales. Such PMFs give rise to excess of power in small scale matter perturbations that could strongly influence structure formation. We study the impact of the magnetically enhanced matter power spectrum on the signal that will be observed by line-intensity mapping (LIM) surveys targeting carbon monoxide (CO) emission from star-forming galaxies at high redshifts. Specifically, the voxel intensity distribution of intensity maps provides access to small-scale information, which makes it highly sensitive to signatures of PMFs on matter overdensities. We present forecasts for future LIM CO surveys, finding that they can constrain PMF strength as small asB1Mpc∼ 0.006–1 nG, depending on the magnetic spectral index and the targeted redshifts.
New Continuum Observations of the Andromeda galaxy M31 with FAST
Authors: Zhang Wenjun , Sun Xiaohui , Wang Jie 
Published: September 2023

Abstract
We present a new total intensity image of M31 at 1.248 GHz, observed with the Five-hundred-meter Aperture Spherical radio telescope (FAST) with an angular resolution of

4
′

and a sensitivity of about 16 mK. The new FAST image clearly reveals weak emission outside the ring due to its high sensitivity on large-scale structures. We derive a scale length of 2.7 kpc for the cosmic ray electrons and find that the cosmic ray electrons propagate mainly through diffusion by comparing the scale length at 4.8 GHz. The spectral index of the total intensity varies along the ring, which can be attributed to the variation of the spectra of synchrotron emission. This variation is likely caused by the change of star formation rates along the ring. We find that the azimuthal profile of the non-thermal emission can be interpreted by an axisymmetric large-scale magnetic field with varying pitch angle along the ring, indicating a complicated magnetic field configuration in M31.
Optimization of parameters for portable X-ray diffraction/X-ray fluorescence combined analysis device (P-XRDF-CAD)
Authors: He Z. , Xu Y.J. , Huang N. , Wang P. , Peng B. , Yuan J.X. , An Z. 
Published: September 2023

Abstract
This paper aims to optimize the parameters of a portable
device that combines X-ray diffraction (XRD) and X-ray fluorescence
(XRF) analysis techniques. By using the same X-ray source and
detector, the device enables the simultaneous acquisition of
two-dimensional XRD and XRF information from a sample with the
advantage of high analysis efficiency and consistency in the
measurement points. The equipment and slit materials are discussed,
including the selection of the X-ray source (Moxtek MAGNUM) and the
detector (Andor CCD camera). We also explore two different slit
designs (the bottom-hole and side-hole) and optimize their
dimensions using rectangular holes instead of inclined trapezoidal
holes. Considering the fluorescence X-rays of the filters in the
X-ray tube spectra, a theoretical formula is derived for rapid and
accurate calculation. The calculated results are compared with the
experimental results of Al and Ni filters, demonstrating good
agreement across various tube voltages and filter
thicknesses. Furthermore, an XRD/XRF comprehensive analysis platform
is established. The effects of tube voltage, tube current, exposure
time, and pixel-binning on the single-pixel events of the CCD camera
are investigated and can be used to guide the selection of
appropriate device parameters. The effects of the frame and tube
voltage on the XRD/XRF analysis efficiency are examined for several
sample materials, including Al, α-Fe, Zn, and
ZrO2(Y2O3).
Nonlinear multivariate constitutive equations for modeling hot deformation behavior
Authors: Ahmedabadi Parag M 
Published: September 2023

Abstract
Nonlinear constitutive equations are proposed to model variations in flow stress as a function of strain rate and temperature during hot deformation. Modified constitutive are applied to seventy data sets about hot deformation of alloys. Two modifications to conventional constitutive models are introduced, viz. (1) nonlinear and (2) multivariate models with the fitting of flow stress simultaneously with two variables. The predictive accuracy of constitutive equations was evaluated using three statistical parameters and compared with a conventional Arrhenius-like model. It is shown that nonlinear constitutive equations have improved predictive accuracy for variations in flow stress during hot deformation. The advantages of multivariate models include less computation and material parameters that are constants independent of temperature or strain rate. In another type of multivariate model, flow stress is expressed as linear and nonlinear polynomial functions of the Zener-Holloman parameter. This approach gives a single value of the activation energy of hot deformation. The results have indicated that a generalized second-order multivariate constitutive equation can be used to better predict flow stress, as a function strain rate and temperature, during hot deformation.
A new method for preventing stress cracking in repairable ceramic packages by changing the sealing ring shape
Authors: Yao Xin , Tian Shuang , Fang Yucai , Jiao Honghao , Wang Jianfeng , Wang Bo , Zhou Jian , Xue Feng 
Published: September 2023

Abstract
High-reliable ceramic packages are impressionable to the parallel seam welding (PSW) parameters leading to low yield and reliability. In this study, the structure of the ceramic package was modified by changing the sealing ring to improve weldability and high-temperature reliability. Three types of ceramic packages with different-shaped sealing rings, which are conventional rectangular rings, notch inward rings, and notch outward rings, were fabricated by Au-Sn soldering and a follow-up PSW process. The packages with the rectangular ring failed in the subsequent high-temperature aging test. The packages with the notch inward ring exhibited an early failure after PSW. Cracks were generated in the Au-Sn solder and propagated into the ceramic substrate. The packages with the notch outward ring exhibited remarkable weldability and reliability. Sequential thermo-structural coupling was used to simulate the temperature and stress distribution in the packages. The maximum principal stress in the aforementioned ceramic substrates rapidly increased to approximately 170.0 MPa, 168.5 MPa and 101.4 MPa in the PSW process. Stress concentration existed at the outside corner around the rectangular and notch inward-shaped sealing rings. The maximum temperature at the local position in the ceramic was raised to 250.3 °C, 238.6 °C and 157.2 °C depending on the shape of the sealing ring. The extra transmission path in the notch outward ring relieved thermal mismatch and deformation at the Au-Sn/ceramic interface during PSW. The packages with notch outward rings were recommended especially in the repairable ceramic packaging.
Climate change hazards, physical infrastructure systems, and public health pathways
Authors: Ikonomova Maria , MacAskill Kristen 
Published: September 2023

Abstract
Climate-related hazards such as heatwaves, flooding, wildfires, and storms will increase morbidity and mortality unless infrastructure decision-makers—including urban planners, infrastructure asset managers, and utility providers—implement preventive measures to protect public health from these hazards. Existing research and policies have not systematically identified the key risk factors that these decision-makers need to manage to protect public health in a changing climate. This gap leads to unclarity regarding what infrastructure interventions are required to prevent climate-related health risks and what actors have a responsibility to manage these risks. The Climate-Health-Infrastructure-Pathways Model is introduced in this paper to address this gap and provide a conceptual map that captures the role of physical infrastructure systems in the pathways between climate-related hazards and health risks. The model surpasses what can be found in existing climate change research and policy, including the latest IPCC reporting, and is a conceptual qualitative tool that offers a typology of climate and health risks for infrastructure management. Decision-makers can use the model as a starting point to review the coverage of their current climate risk management plans and identify further opportunities to develop preventive infrastructure responses to protect public health in a changing climate.
Iron deficiency in myocardial ischaemia: molecular mechanisms and therapeutic perspectives
Authors: Corradi Francesco , Masini Gabriele , Bucciarelli Tonino , De Caterina Raffaele 
Published: September 2023

Abstract
Systemic iron deficiency (SID), even in the absence of anaemia, worsens the prognosis and increases mortality in heart failure (HF). Recent clinical–epidemiological studies, however, have shown that a myocardial iron deficiency (MID) is frequently present in cases of severe HF, even in the absence of SID and without anaemia. In addition, experimental studies have shown a poor correlation between the state of systemic and myocardial iron. MID in animal models leads to severe mitochondrial dysfunction, alterations of mitophagy, and mitochondrial biogenesis, with profound alterations in cardiac mechanics and the occurrence of a fatal cardiomyopathy, all effects prevented by intravenous administration of iron. This shifts the focus to the myocardial state of iron, in the absence of anaemia, as an important factor in prognostic worsening and mortality in HF. There is now epidemiological evidence that SID worsens prognosis and mortality also in patients with acute and chronic coronary heart disease and experimental evidence that MID aggravates acute myocardial ischaemia as well as post-ischaemic remodelling. Intravenous administration of ferric carboxymaltose (FCM) or ferric dextrane improves post-ischaemic adverse remodelling. We here review such evidence, propose that MID worsens ischaemia/reperfusion injury, and discuss possible molecular mechanisms, such as chronic hyperactivation of HIF1-α, exacerbation of cytosolic and mitochondrial calcium overload, amplified increase of mitochondrial [NADH]/[NAD+] ratio, and depletion of energy status and NAD+ content with inhibition of sirtuin 1–3 activity. Such evidence now portrays iron metabolism as a core factor not only in HF but also in myocardial ischaemia.
Non-invasive estimation of left ventricular systolic peak pressure: a prerequisite to calculate myocardial work in hypertrophic obstructive cardiomyopathy
Authors: Batzner Angelika , Hahn Patrick , Morbach Caroline , Störk Stefan , Maack Christoph , Verheyen Nicolas , Gerull Brenda , Frantz Stefan , Seggewiss Hubert 
Published: September 2023

Abstract

Aims
Myocardial work (MyW) is an echocardiographically derived parameter to estimate myocardial performance. The calculation of MyW utilizes pressure strain loops from global longitudinal strain and brachial blood pressure (BP) as a surrogate of left ventricular systolic pressure (LVSP). Since LVSP cannot be equated with BP in hypertrophic obstructive cardiomyopathy (HOCM), we explored whether LVSP can be derived non-invasively by combining Doppler gradients and BP.

Methods and results
We studied 20 consecutive patients (8 women, 12 men; mean age 57.0 ± 13.9 years; NYHA 2.1 ± 0.8; maximal septal thickness 24.7 ± 6.3 mm) with indication for first alcohol septal ablation. All measurements were performed simultaneously in the catheterization laboratory (CathLab)—invasively: ascending aortic and LV pressures; non-invasively: BP, maximal (CWmax) and mean (CWmean) Doppler gradients.
LVSP was 188.9 ± 38.5 mmHg. Mean gradients of both methods were comparable (CathLab 34.3 ± 13.4 mmHg vs. CW 31.0 ± 13.7 mmHg). Maximal gradient was higher in echocardiography (64.5 ± 28.8 mmHg) compared with CathLab (54.8 ± 24.0 mmHg; P &lt; 0.05). Adding BP (143.1 ± 20.6 mmHg) to CWmax resulted in higher (207.7 ± 38.0 mmHg; P &lt; 0.001), whereas adding BP to CWmean in lower (174.1 ± 26.1 mmHg; P &lt; 0.01) derived LVSP compared with measured LVSP. However, adding BP to averaged CWmax and CWmean resulted in comparable results for measured and derived LVSP (190.9 ± 31.6 mmHg) yielding a favourable correlation (r = 0.87, P &lt; 0.001) and a good level of agreement in the Bland–Altman plot.

Conclusion
Non-invasive estimation of LVSP in HOCM is feasible by combining conventional BP and averaged CWmean and CWmax gradients. Hereby, a more reliable estimation of MyW in HOCM may be feasible.
Examining the Malleability of Negative Views of Aging, Self-Efficacy Beliefs, and Behavioral Intentions in Middle-Aged and Older Adults
Authors: Diehl Manfred , Rebok George W , Roth David L , Nehrkorn-Bailey Abigail , Rodriguez Diana , Tseng Han-Yun , Chen Diefei 
Published: September 2023

Abstract

Objectives
This study examined the malleability of a tripartite cluster of purported mechanistic variables targeted in a 4-week intervention program designed to improve adults’ engagement in physical activity. The targeted cluster of purported mechanisms consisted of negative views of aging (NVOA), self-efficacy beliefs, and behavioral intentions.

Methods
A randomized single-blind control group design was used to implement the AgingPLUS program in a sample of middle-aged and older adults (N = 335; Mage = 60.1 years; SDage = 8.3 years; age range 45–75 years).

Results
Using an intention-to-treat approach and analyses of covariance adjusting for participants’ baseline scores, findings showed significant improvements in the purported mechanistic variables both at the immediate (Week 4) and delayed posttest (Week 8) in the treatment group but not in the control group. These improvements were for the most part maintained until 8-month postrandomization, although to a smaller extent. Specifically, participants in the AgingPLUS group showed significant improvements in NVOA, self-efficacy beliefs, and behavioral intentions compared to the Health Education control group. Standardized effect sizes for statistically significant effects were variable and ranged from small (d = −0.23) to large (d = 0.80). Effect sizes showed some decay of the intervention at the 8-month posttest.

Discussion
Taken together, the findings supported the efficacy of the AgingPLUS program and showed that variables representing the purported mechanisms of the intervention were significantly moved in a positive direction. In doing so, the AgingPLUS program met a major requirement of the experimental medicine approach to behavior change interventions.

Clinical Trials Registration Number
NCT0329948
Associations of Perceived Stress and Psychological Resilience With Cognition and a Modifiable Dementia Risk Score in Middle-Aged Adults
Authors: Franks Katherine H , Bransby Lisa , Cribb Lachlan , Buckley Rachel , Yassi Nawaf , Chong Trevor T -J , Saling Michael M , Lim Yen Ying , Pase Matthew P 
Published: September 2023

Abstract

Objectives
Psychological stress has been proposed as a risk factor for cognitive impairment and dementia. However, it remains unclear how an individual’s stress-coping ability (i.e., psychological resilience) is related to cognition. This cross-sectional study investigated whether perceived stress and psychological resilience were associated with cognition and a modifiable dementia risk score in a large community-based sample of cognitively normal adults. The moderating effect of psychological resilience was also examined.

Methods
Participants (mean age = 57 ± 7 years) enrolled in the web-based Healthy Brain Project completed the Perceived Stress Scale and the Connor–Davidson Resilience Scale. Domains of attention and working memory were assessed using the Cogstate Brief Battery (n = 1,709), and associative memory was assessed using the Cambridge Neuropsychological Test Automated Battery (n = 1,522). Dementia risk was estimated for 1,913 participants using a modified version of the Cardiovascular Risk Factors, Aging, and Incidence of Dementia dementia risk score, calculated using only readily modifiable dementia risk factors.

Results
In separate linear regression analyses adjusted for age, sex, education, and race, greater levels of perceived stress and lower levels of psychological resilience were associated with poorer performance across all cognitive domains, as well as a higher modifiable dementia risk score. Psychological resilience did not moderate the effect of perceived stress on cognition or the dementia risk score.

Discussion
Higher perceived stress and lower resilience were associated with poorer cognition and a greater burden of modifiable dementia risk factors. Intervention studies are required to determine if lowering stress and building resilience can mitigate cognitive deficits and reduce dementia risk.
Random attractors for a stochastic nonlocal delayed reaction–diffusion equation on a semi-infinite interval
Authors: Hu Wenjie , Zhu Quanxin , Caraballo Tomás 
Published: September 2023

Abstract
The aim of this paper is to prove the existence and qualitative property of random attractors for a stochastic non-local delayed reaction–diffusion equation (SNDRDE) on a semi-infinite interval with a Dirichlet boundary condition at the finite end. This equation models the spatial–temporal evolution of the mature individuals for a two-stage species whose juvenile and adults both diffuse that lives on a semi-infinite domain and subject to random perturbations. By transforming the SNDRDE into a random evolution equation with delay, by means of a stationary conjugate transformation, we first establish the global existence and uniqueness of solutions to the equation, after which we show the solutions generate a random dynamical system. Then, we deduce uniform a priori estimates of the solutions and show the existence of bounded random absorbing sets. Subsequently, we prove the pullback asymptotic compactness of the random dynamical system generated by the SNDRDE with respect to the compact open topology, and hence obtain the existence of random attractors. At last, it is proved that the random attractor is an exponentially attracting stationary solution under appropriate conditions. The theoretical results are illustrated by application to the stochastic non-local delayed Nicholson’s blowfly equation.