bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal safe driving dynamics for autonomous interacting vehicles
Authors: Cohen Nathan , Chopard Bastien , Leone Pierre 
Published: September 2023

AbstractWe consider the car following problem for a set of autonomous vehicles following each other on either an infinite or circular road. The behavior of each car is specified by its "speed regulator", a device that decides to increase or decrease the speed of the car as a function of the head-tail distance to its predecessor and the speed of both cars. A collective behavior emerges that corresponds to previously proposed cellular automata traffic models. We further analyze the traffic patterns of the system in the long term, as governed by the speed regulator and we study under which conditions traffic patterns of maximum flow can or cannot be reach. We show the existence of suboptimal flow conditions that require external coordination mechanisms (that we do not consider in this paper) in order to reach the optimal flow achievable with the given density. In contrast with other approaches, we do not try to reproduce observed or measured traffic patterns. We analyze a deterministic speed regulator in order to decipher the emergent dynamics, and to ponder what maneuvers can be safely performed. Here, we restrict our attention to the car following problem. By comparing our speed regulator with classical models, auch as the Nagel–Schreckenberg and KKW models, we observe that although our regulator is formulated in simple terms, its dynamics share similarities with these models. In particular, the KKW model is designed to reproduce the observed behavior that a trailing car in the synchronization range of the leading car tends to regulate its speed to maintain a constant distance. this same behavior is adopted by our speed regulator, showing that this is a safe way of driving.
Characterizing human health damage from ionizing radiation in life cycle assessment
Authors: Paulillo Andrea , McKone Thomas E , Fantke Peter 
Published: September 2023

Abstract
Purpose
Although a wide number of industrial processes routinely release radionuclides into the environment, the resulting potential impacts on human health have been largely overlooked in life cycle assessment (LCA). As part of the Life Cycle Initiative project on Global Guidance for Life Cycle Impact Assessment Indicators and Methods (GLAM), we aim to develop a consensus-based source-to-damage framework and factors for characterizing human health damage from ionizing radiation in LCA.

Methods
Our framework comprises four modules. The fate and exposure modules are based on UCrad, an earlier developed compartment-based environmental model for radionuclides. The focus of the present work is on the dose response and severity modules, which are based on most recent data from the International Committee on Radiological Protection and the Global Burden of Disease project series. The characterization factors are expressed in terms of DALY per kBq released.

Results and discussions
We obtain characterization factors for 115 radionuclides and 8 environmental compartments. To evaluate our approach, we compare both effect factors (combining dose response and severity) and characterization factors with those proposed in earlier studies. Our analysis demonstrates that differences are explicable by the different approaches used in the fate and exposure modelling. We also test the sensitivity of our factors to different approaches for filling data gaps, suggesting that our factors are robust. Finally, we apply our factors in an illustrative case study on rice production and consumption under various scenarios to identify dominant radionuclides and how these differ when other approaches are used.

Conclusions
Our framework is aligned with widely adopted methodologies for human health impact assessment, thus enabling robust comparisons, and covers nearly all radionuclides released by anthropogenic activities, including those that may arise from disposal of nuclear waste. Our factors are readily applicable for assessing radionuclide emissions in LCA. As next step we recommend (i) incorporating decay products into the fate model and (ii) integrating a model for indoor emissions of radon and indoor exposure to naturally occurring radionuclides (NORM).
Flesh Without Blood: The Public Health Benefits of Lab‐Grown Meat
Authors: Anomaly Jonny , Browning Heather , Fleischman Diana , Veit Walter 
Published: September 2023

AbstractSynthetic meat made from animal cells will transform how we eat. It will reduce suffering by eliminating the need to raise and slaughter animals. But it will also have big public health benefits if it becomes widely consumed. In this paper, we discuss how “clean meat” can reduce the risks associated with intensive animal farming, including antibiotic resistance, environmental pollution, and zoonotic viral diseases like influenza and coronavirus. Since the most common objection to clean meat is that some people find it “disgusting” or “unnatural,” we explore the psychology of disgust to find possible counter-measures. We argue that the public health benefits of clean meat give us strong moral reasons to promote its development and consumption in a way that the public is likely to support. We end by depicting the change from farmed animals to clean meat as a collective action problem and suggest that social norms rather than coercive laws should be employed to solve the problem.
Increased Knowledge Mediates the Effect of Game Changers for Cervical Cancer Prevention on Diffusion of Cervical Cancer Screening Advocacy Among Social Network Members in a Pilot Trial
Authors: Ghai Ishita , Wagner Glenn J. , Matovu Joseph K. B. , Juncker Margrethe , Namisango Eve , Bouskill Kathryn , Nakami Sylvia , Beyeza-Kashesya Jolly , Luyirika Emmanuel , Wanyenze Rhoda K. 
Published: September 2023

Abstract
Background
Game Changers for Cervical Cancer Prevention (GC-CCP), a peer-led, group advocacy training intervention, increased cervical cancer (CC) prevention advocacy not only among intervention recipients, but also their social network members (referred to as “alters”) who were targeted with advocacy in a pilot randomized controlled trial. We examined mediators and moderators of this effect on alter advocacy, to understand how and for whom the intervention had such an effect.

Method
Forty women (index participants) who had recently screened for CC enrolled and were randomly assigned to receive the GC-CCP intervention (n = 20) or the wait-list control (n = 20). Up to three alters from each participant (n = 103) were surveyed at baseline and month 6. Measures of CC-related cognitive constructs (knowledge, enacted stigma, and risk management self-efficacy), as well as extent of advocacy received from index participants, were assessed as mediators of the intervention effect on alter advocacy using multivariate regression analyses. Alter characteristics were examined as moderators.

Results
Increased CC-related knowledge partially mediated the intervention effect on increased alter engagement in CC prevention advocacy; those with greater gains in knowledge reported greater engagement in advocacy. No moderators of the intervention effect were identified.

Conclusion
The effect of GC-CCP on alter CC prevention advocacy is enhanced by increased alter knowledge pertaining to CC prevention, causes, and treatment and suggests this may be key for diffusion of intervention effects on increased CC prevention advocacy throughout a social network.

Trial Registration
NCT04960748 (registered on clinicaltrials.gov, 7/14/2021).
A Soluble ‘Ba(Ni-ett)’ (ett = 1,1,2,2-Ethenetetrathiolate) Derived Thermoelectric Material
Authors: Hu Yaoyang , Rivers Geoffrey , Weir Michael P. , Amabilino David B. , Tuck Christopher J. , Wildman Ricky D. , Makarovsky Oleg , Woodward Simon 
Published: September 2023

AbstractWe describe the synthesis and characterisation of the first of a new class of soluble ladder oligomeric thermoelectric material based on previously unutilised ethene-1,1,2,2-tetrasulfonic acid. Reaction of Ba(OH)2 and propionic acid at a 1:1 stoichiometry leads to the formation of the previously unrecognised soluble [Ba(OH)(O2CEt)]⋅H2O. The latter when used to hydrolyse 1,3,4,6-tetrathiapentalene-2,5-dione (TPD), in the presence of NiCl2, forms a new material whose elemental composition is in accord with the formula [(EtCO2Ba)4Ni8{(O3S)2C = C(SO3)2}5]⋅22H2O (4). Compound 4 can be pressed into pellets, drop-cast as DMSO solutions or ink-jet printed (down to sub-mm resolutions). While its room temperature thermoelectric properties are modest (σmax 0.04 S cm−1 and Seebeck coefficient, αmax − 25.8 μV K−1) we introduce a versatile new oligomeric material that opens new possible synthetic routes for n-type thermoelectrics.
Graphical Abstract
The Influence of Selected Insecticides on the Oxidative Response of Atta sexdens (Myrmicinae, Attini) Workers
Authors: Poiani Silvana Beani , Dobeš Pavel , Kunc Martin , Pereira Mayara Cristina , Bueno Odair Correa , Hyršl Pavel 
Published: September 2023

AbstractReactive oxygen species (ROS) are generated as products of normal cellular metabolic activities; however, the use of pesticides to control leafcutter ants leads to unbalanced ROS production. We evaluated the effects of two insecticides (fipronil, sulfluramid) and metallic insecticide complex (magnesium complex [Mg(hesp)2(phen)] (1)) on the superoxide dismutase (SOD), glutathione (GSH) and the overall antioxidant capacity using two different methodologies: total radical-trapping potential (TRAP) and oxygen radical absorbance capacity (ORAC). Media workers of Atta sexdens (C. Linnaeus) were exposed to the insecticides for 24 h, 48 h, 72 h and 96 h before their fat bodies were dissected for analysis. The results showed that although the sulfluramid may cause the production of ROS, its slow action in the organism does not lead to oxidative stress. There is a rise in oxidative stress in workers of leafcutter ants treated with fipronil because SOD significantly increased when compared to the control group. On the other hand, Mg1-complex suppressed both GSH and SOD, indicating that the immune system may be affected by Mg1-complex, which has a delayed activity ideal for its use in chemical pest control. Both TRAP and ORAC evaluated total antioxidant capacities; however, ORAC proved to be a more sensitive method. In conclusion, the Mg1-complex is a new compound that should be further investigated as a potential replacement for fipronil and sulfluramid in pest control.
From Natural Towards Representative Decision Making in Sports: A Framework for Decision Making in Virtual and Augmented Environments
Authors: Janssen Tim , Müller Daniel , Mann David L. 
Published: September 2023

AbstractDecision making is vital in complex sporting tasks but is difficult to test and train. New technologies such as virtual and augmented reality offer novel opportunities for improving decision making, yet it remains unclear whether training gains using these new approaches will improve decision making on-field. To clarify the potential benefits, a clear conceptualization of decision making is required, particularly for invasive team sports such as football, basketball and field hockey, where decisions are complex with many possible options offered. Therefore, the aim of this position paper is to establish a framework for the design of virtual and augmented environments that help invasive team sport athletes to train their decision-making capacities. To achieve this, we propose a framework for conceptualising ‘natural’ decision making within the performance environment in invasive team sports that views decision making as a continuous cyclical process where the ball carrier interacts with teammates to create ‘windows of opportunity’, and where skilled decision makers often delay decisions to create time, and in turn new opportunities, rather than necessarily selecting the first option available to them. Within the framework, we make a distinction between decision making and anticipation, proposing that decision making requires a series of on-going anticipatory judgments. Based on the framework, we subsequently highlight the consequences for testing and training decision making using virtual and augmented reality environments, in particular outlining the technological challenges that need to be overcome for natural decision making to be represented within virtual and augmented environments.
Estimates for evolutionary partial differential equations in classical function spaces
Authors: Castro Alejandro J. , Israelsson Anders , Staubach Wolfgang , Yerlanov Madi 
Published: September 2023

Abstract
We establish new local and global estimates for evolutionary partial differential equations in classical Banach and quasi-Banach spaces that appear most frequently in the theory of partial differential equations. More specifically, we obtain optimal (local in time) estimates for the solution to the Cauchy problem for variable-coefficient evolutionary partial differential equations. The estimates are achieved by introducing the notions of Schrödinger and general oscillatory integral operators with inhomogeneous phase functions and prove sharp local and global regularity results for these in Besov–Lipschitz and Triebel–Lizorkin spaces.
Decolonization of Global Health Law: Lessons from International Environmental Law
Authors: Phelan Alexandra L. , Sirleaf Matiangai 
Published: September 2023

AbstractGlobal health law for pandemics currently lacks legal obligations to ensure distributional and reparative justice. In contrast, international environmental law contains several novel international legal mechanisms aimed at addressing the effects of colonialism and global injustices that arise from the disproportionate contributions to — and impacts of — climate change and biodiversity loss.
Adolescent psychological adjustment and social supports during pandemic-onset remote learning: A national multi-wave daily-diary study
Authors: Wang Ming-Te , Scanlon Christina L. , Del Toro Juan , Qin Xu 
Published: September 2023

AbstractIn spring 2020, U.S. schools universally transitioned to online learning due to the COVID-19 pandemic’s onset, thus creating a natural experiment for examining adolescents’ risk and resilience during an ongoing school crisis response. This longitudinal study used a daily-diary approach to investigate the role of social support in the link between remote learning and psychological well-being across 64 days among a national sample of adolescents (n = 744; 42% Black, 36% White, 22% Other ethnicity/race; 41% boys; 72% eligible for free/reduced-priced lunch; Mage=14.60, SDage=1.71, age-range = 12–17 years). On days when youth attended remote learning, they reported lower daily positive affect, more daily stress, and higher parent social support. There were no significant differences in the effect of remote learning on affect or stress by race or economic status. On days when youth experienced more parent support, they reported lower daily stress and negative affect and higher daily positive affect. On days when youth experienced more peer support, they reported higher daily positive affect. Overall, the study highlights the impact of pandemic-onset remote learning on adolescents’ psychological well-being and emphasizes the need for future research on school crisis contingency planning to address these challenges.
Sino–Japanese third-party market cooperation: asymmetries of economic diplomacy and politico-economic gaps
Authors: Zhang Muhui 
Published: September 2023

AbstractIn the wake of the intensifying Sino–Japanese rivalry in Asia, a new third-party market cooperation (TPMC) framework emerged in late 2018. The new mechanism was inaugurated around the time of former Japanese Prime Minister Shinzo Abe's visit to Beijing, displaying new attempts at Sino–Japanese economic diplomacy. Nonetheless, this article highlights the absence of major cooperative outcomes and suggests a pessimistic vision of TPMC's future, as three pairs of politico-economic gaps have led to asymmetries in the approaches adopted by China and Japan. First, a government-to-government policy asymmetry occurred between China's initiatives and Japan's responsiveness, as the latter merely utilized the TPMC as a temporary diplomatic tool to restore bilateral relations in late 2018 and appeared to have lost its policy momentum in the following years. Second, asymmetries in business modes and investment management between the two countries' enterprises have led to technical barriers in materializing the two governments' agreements into specific TPMC business collaboration. This study illustrated a project of Sino–Japanese collaboration in building a high-speed railway in Thailand, and saw this failed case as a warning for existing gaps of commercial modes. Third, both countries are now confronted with domestic underdeveloped public–private partnerships between state and private sectors. This article also aims to provide some policy-oriented implications for steadily implementing the Sino–Japanese TPMC in the future.
GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation
Authors: Shinzawa Koei , Matsumoto Shinji , Sada Ryota , Harada Akikazu , Saitoh Kaori , Kato Keiko , Ikeda Satsuki , Hirayama Akiyoshi , Yokoi Kazunori , Tanemura Atsushi , Nimura Keisuke , Ikawa Masahito , Soga Tomoyoshi , Kikuchi Akira 
Published: September 2023

AbstractGrowth regulation by estrogen in breast cancer 1 (GREB1) is involved in hormone-dependent and -independent tumor development (e.g., hepatoblastoma). In this study, we found that a GREB1 splicing variant, isoform 4 (Is4), which encodes C-terminal half of full-length GREB1, is specifically expressed via microphthalmia-associated transcription factor (MITF) in melanocytic melanoma, and that two MITF-binding E-box CANNTG motifs at the 5’-upstream region of GREB1 exon 19 are necessary for GREB1 Is4 transcription. MITF and GREB1 Is4 were strongly co-expressed in approximately 20% of the melanoma specimens evaluated (17/89 cases) and their expression was associated with tumor thickness. GREB1 Is4 silencing reduced melanoma cell proliferation in association with altered expression of cell proliferation-related genes in vitro. In addition, GREB1 Is4 targeting by antisense oligonucleotide (ASO) decreased melanoma xenograft tumor formation and GREB1 Is4 expression in a BRAFV600E; PTENflox melanoma mouse model promoted melanoma formation, demonstrating the crucial role of GREB1 Is4 for melanoma proliferation in vivo. GREB1 Is4 bound to CAD, the rate-limiting enzyme of pyrimidine metabolism, and metabolic flux analysis revealed that GREBI Is4 is necessary for pyrimidine synthesis. These results suggest that MITF-dependent GREB1 Is4 expression leads to melanoma proliferation and GREB1 Is4 represents a new molecular target in melanoma.
Reducing intrusive memories after trauma via an imagery-competing task intervention in COVID-19 intensive care staff: a randomised controlled trial
Authors: Iyadurai Lalitha , Highfield Julie , Kanstrup Marie , Markham Alfred , Ramineni Varsha , Guo Boliang , Jaki Thomas , Kingslake Jonathan , Goodwin Guy M. , Summers Charlotte , Bonsall Michael B. , Holmes Emily A. 
Published: September 2023

AbstractIntrusive memories (IMs) after traumatic events can be distressing and disrupt mental health and functioning. We evaluated the impact of a brief remotely-delivered digital imagery-competing task intervention on the number of IMs for intensive care unit (ICU) staff who faced repeated trauma exposure during the COVID-19 pandemic using a two-arm, parallel-group, single-blind randomised controlled trial, with the comparator arm receiving delayed access to active treatment (crossover). Eligible participants worked clinically in a UK NHS ICU during the pandemic and had at least 3 IMs of work-related traumatic events in the week before recruitment. Participants were randomly assigned (1:1) to immediate (weeks 1–4) or delayed (weeks 5–8) intervention access. Sequential Bayesian analyses to optimise the intervention and increase trial efficiency are reported elsewhere [1]. The primary endpoint for the pre-specified frequentist analysis of the final study population compared the number of IMs experienced in week 4 between the immediate and delayed access arms. Secondary outcomes included clinical symptoms, work functioning and wellbeing. Safety was assessed throughout the trial by scheduled questions and free report. All analyses were undertaken on an intention-to-treat basis (86 randomised participants). There were significantly fewer intrusive memories during week 4 in the immediate (median = 1, IQR = 0–3,n = 43), compared to the comparator delayed arm (median = 10, IQR = 6–17,n = 43), IRR 0.31, 95% CI: 0.20–0.48,p < 0.001. After crossover, the delayed arm also showed a significant reduction in IMs at week 8 compared to week 4. There were convergent findings for symptoms of PTSD, insomnia and anxiety, work engagement and burnout, general functioning and quality of life. The intervention was found safe and acceptable to participants. All adverse events were unrelated to the study. Our study provides the first evidence of a benefit on reducing IMs, improving other clinical symptoms, work functioning and wellbeing, as well as safety of a brief remotely-delivered digital imagery-competing task intervention. An efficacy trial with an active control and longer follow-up is warranted. The trial is registered at ClinicalTrials.gov (NCT04992390).
Genome-wide analysis of anorexia nervosa and major psychiatric disorders and related traits reveals genetic overlap and identifies novel risk loci for anorexia nervosa
Authors: Bang Lasse , Bahrami Shahram , Hindley Guy , Smeland Olav B. , Rødevand Linn , Jaholkowski Piotr P. , Shadrin Alexey , Connell Kevin S. O’ , Frei Oleksandr , Lin Aihua , Rahman Zillur , Cheng Weiqiu , Parker Nadine , Fan Chun C. , Dale Anders M. , Djurovic Srdjan , Bulik Cynthia M. , Andreassen Ole A. 
Published: September 2023

AbstractAnorexia nervosa (AN) is a heritable eating disorder (50–60%) with an array of commonly comorbid psychiatric disorders and related traits. Although significant genetic correlations between AN and psychiatric disorders and related traits have been reported, their shared genetic architecture is largely understudied. We investigated the shared genetic architecture of AN and schizophrenia (SCZ), bipolar disorder (BIP), major depression (MD), mood instability (Mood), neuroticism (NEUR), and intelligence (INT). We applied the conditional false discovery rate (FDR) method to identify novel risk loci for AN, and conjunctional FDR to identify loci shared between AN and related phenotypes, to summarize statistics from relevant genome-wide association studies (GWAS). Individual GWAS samples varied from 72,517 to 420,879 participants. Using conditional FDR we identified 58 novel AN loci. Furthermore, we identified 38 unique loci shared between AN and major psychiatric disorders (SCZ, BIP, and MD) and 45 between AN and psychological traits (Mood, NEUR, and INT). In line with genetic correlations, the majority of shared loci showed concordant effect directions. Functional analyses revealed that the shared loci are involved in 65 unique pathways, several of which overlapped across analyses, including the “signal by MST1” pathway involved in Hippo signaling. In conclusion, we demonstrated genetic overlap between AN and major psychiatric disorders and related traits, and identified novel risk loci for AN by leveraging this overlap. Our results indicate that some shared characteristics between AN and related disorders and traits may have genetic underpinnings.