bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Variability in Morphology, Course, and Anatomical Types Observed in Nasopalatine Canal Using CBCT: A Retrospective Study
Authors: Singh Simran , Hebbale Manjula , Mhapuskar Amit , Jadhav Santosh , Mahapatra Subharina , Pillai Vedika 
Published: January 2025

Abstract

Introduction:
With the emerging trends in the dental practice, dental implants remain the up-front choice of replacing edentulous spaces. A detailed assessment of the anatomical landmarks, implant bone dimension, and bone quality evaluation by the radiologist is the key for successful implant placement. Knowledge of the nasopalatine canal anatomy, variability in shape, and possible pathologies associated with it are the mainstay for successful implant placement in maxilla.

Aim:
The study was conducted with the aim to study variations in morphology, course, and anatomical type of the nasopalatine canal. (NPC).

Methodology:
A total of two hundred CBCT scans were evaluated to study the variations in morphology, course, and anatomical types of the NPC, and the statical analysis was conducted for the same.

Results:
A total of two hundred CBCT scans were retrospectively analyzed. The most common morphology of the canal observed was funnel shaped in 52.5%, followed by cylindrical observed in 19.5%. Slanted curved was the most observed course of the canal seen in 38%. On comparing the above two parameters between the gender group, the results were statistically significant for the abovementioned parameters for both the groups (P value < 0.001*). The most common anatomical type observed was Type II which was observed in 67%.

Conclusion:
NPC is an important anatomical landmark to be considered when any dental procedures like dental implants are planned in anterior maxilla. The knowledge regarding the NPC morphology among the clinicians is of paramount importance in successful placement of implants and also other surgical procedures related to the anterior maxillary region.
Kimura Disease: A Rare Case with Multiple Recurrences involving Subcutaneous Tissue, Parotid Gland, and Lymph Nodes
Authors: Das Sukanya , Chavan Mahesh , Khare Vikram V. , Gaikwad Trupti 
Published: January 2025

Abstract
Kimura disease (KD) is an uncommon, long-standing inflammatory condition affecting the head and neck that has no recognized cause. It typically appears as a painless subcutaneous nodule mimicking a tumor. The characteristic triad other the painless subcutaneous masses include elevated serum immunoglobulin E and peripheral eosinophilia. We present a unique instance of KD involving a male individual, age 23 years, who has swelling in the pre-auricular area on the left side of the face. Establishing KD as a probable differential diagnosis is the key to prompt treatment, declining misdiagnosis, and enhancing the quality of the patient’s life.
Central Hemangioma of Mandibular Ramus Masquerading as Parotid Adenoma: A Case Report
Authors: Athisayakani Miraculie G. , Mohapatra Shreeyam , Debta Priyanka , Debta Fakir Mohan 
Published: January 2025

Abstract
Intraosseous hemangiomas rarely occur in jaw bones. Clinically, mucosal and soft tissue lesions are easily diagnosed, but intrabony lesions are difficult to distinguish due to varying symptoms, ranging from tooth mobility to pulsatile bleeding. These lesions also exhibit marked variability in their radiological appearance. We present a rare case report of a 75-year-old male with cavernous hemangioma of the left mandible with vague clinical features but characteristic radiographic and histological features.
“Incidentaloma” in Nasal Cavity: A Unique Case Report
Authors: Lakshmi Krithika C. , Ganesan Anuradha , Aniyan K Yesoda , Gauthaman Jeevitha 
Published: January 2025

Abstract
Foreign bodies are a frequent occurrence in the ear, nose, and throat region, especially in children under the age of three years. They can either remain unnoticed for a long period of time or may cause severe complications depending on the location and type of foreign body. A 16-year-old female patient reported the chief complaint of esthetic correction of teeth. On routine radiological examination, a radio-opaque mass was evident in the nasal cavity. The patient was completely asymptomatic. The mass was removed and identified as a goose-berry seed. This is the first reported case in which the patient had remained thoroughly asymptomatic for years together after a lodged foreign body. Such case reports are necessary to enhance the knowledge of radiologists in locating incidental findings so that it reduces the risk of performing unnecessary additional examinations and to prevent further complications.
Comparative Evaluation of Fusobacterium and Leptotrichia among Patients with Oral Leukoplakia and Healthy Individuals
Authors: Balasubramanian Senthil Kumar , Lakshmi Suman Jhansi , Kumar J Anand , Selvam Keerthana , Davidson S Sam Ponraj , Gomathi R 
Published: January 2025

Abstract

Background and Objectives:
The present study attempts to evaluate and assess the presence of Fusobacterium, Leptotrichia, and Campylobacter among patients manifesting oral leukoplakia and healthy individuals. The aim is to compare variations in the presence of total microbiomes in the oral cavity of patients manifesting oral leukoplakia and healthy individuals.

Methods:
This study comprised 55 male subjects, 27 with a history of tobacco smoking (leukoplakia patients) and 28 healthy individuals (nonsmokers) within the age range of 30 years and above. Mucosal swabs were collected from the oral sites of the subjects, and the microbial counts were assessed in the laboratory. Comparative evaluation of Fusobacterium, Leptotrichia, and the total microbiome of oral leukoplakia patients and healthy individuals was statistically analyzed using SPSS version 22.0.

Results:
The culture analysis of the study subject samples indicated a higher value of total microbial flora count, Fusobacterium, and Leptotrichia when compared to that of control subjects.

Conclusions:
This study suggests Fusobacterium and Leptotrichia may have a major influence in the malignant transformation of leukoplakia.
Correlation Between Salivary Levels and Tissue Expression Status of HER2 in Breast Cancer Patients – A Cross-Sectional Study
Authors: Arthisri Anandhi Sekar , Massillamani F , Vinothkumar Thilla Sekar , Veeraraghavan Vishnu Priya 
Published: January 2025

Abstract

Background:
Breast cancer constitutes a significant proportion of malignancies among the female population, accounting for approximately 25% of all cancer cases on a global scale. Human epidermal growth factor receptor-2 (HER2) is the more reliable marker in breast cancer diagnosis.

Objective:
This study investigates the potential of soluble salivary HER2 in breast cancer diagnosis and explores its correlation with demographic and hormonal factors.

Materials and Methods:
A total of 45 subjects were selected and divided into three groups: Group A: healthy patients (n = 15), Group B: HER2-negative breast cancer patients (n = 15), and Group C: HER2-positive breast cancer patients (n = 15). Patients’ saliva was collected, and assessment of salivary soluble HER2 was performed by using an enzyme-linked immunosorbent assay kit.

Results:
Salivary HER2 levels were 32.3 pg/ml in healthy group, 43.2 pg/ml in HER2-negative group, and 147.8 pg/ml in HER2-positive group. On evaluating the risk factors associated with the salivary HER2 levels, increased age (P = 0.007), positive family history (P = 0.006), patients with the habit of tobacco chewing (P = 0.001), and patients with no breastfeeding history (P = 0.001) showed a statistically significant result.

Conclusion:
Salivary HER2 levels were higher in both HER2-positive and -negative breast cancer groups compared to controls, indicating its potential as a noninvasive diagnostic tool for breast cancer screening.
Soft Tissue Myxoma Involving Palatal Gingiva: A Diagnostic Dilemma
Authors: Parakh Samata , Aditya Amita , Mishra Sunil , Shinde Omkar 
Published: January 2025

Abstract
Soft tissue myxomas are extremely rare benign soft tissue tumors of the oral cavity. They comprise of myxoid ground substance and often present as painless, slow-growing masses. Their differential diagnosis is challenging due to their non-specific clinical features and histopathologic similarities with other tumors of myxoid stroma. In this communication, diagnosis and management of soft tissue myxoma in the anterior palatal gingiva of a 22-year-old male patient is reported which clinically appeared as a routine hyperplastic growth. Both the incidence and location of this tumor was rare and has been sparsely reported in the literature.
Progressive Hemifacial Atrophy (Parry-Romberg Syndrome)
Authors: Aswath Nalini , Rakshanaa Rajalakshmi 
Published: January 2025

Abstract
Progressive hemifacial atrophy (PHA), also known as Parry-Romberg syndrome (PRS), is an auto-limitable condition with unknown etiology, characterized by slow and progressive hemiatrophy affecting one side of the face. It is a rare disorder, causing degenerative deformities involving the skin, subcutaneous tissue, and muscles, and sometimes extending to the osteocartilaginous structures, causing aesthetic, functional, and psychological problems, eventually affecting the quality of life of the patient. Management involves a multidisciplinary approach.
Comparative Study of Urethral Plate and Glans Characteristics in Experimentally Created Hypospadias and Clinical Cases Undergoing Snodgrass Repair
Authors: Rajput Manish , Gupta Archika , Singh Gurmeet , Rai Rahul Kumar , Kureel Shiv Narain , Manik Punita , Chauhan Navneet , Rawat Jiledar 
Published: January 2025

ABSTRACT

Aim:
The aim of this study was to study the urethral plate and glans configuration in experimentally created hypospadias in male human cadavers and its comparison with hypospadias patients planned for tubularized incised plate (TIP) urethroplasty.

Materials and Methods:
In five fresh human cadavers, hypospadias was created by placing one blade of scissors in the urethra and the other onto the ventral median raphe and cutting through the skin, penile dartos, and urethra and laying open urethral edges were sutured to edges of penile skin to create hypospadias. Urethral plate characteristics were recorded using Likert scale and the glans groove using the Plate Objective Scoring Tool (POST). The characters were compared with fifty hypospadias planned for TIP.

Results:
In experimentally created hypospadias, all urethral plates were very favorable with POST ratio being >1.5. In 50 hypospadias, cleft urethral plate with POST ratio >1.2 was recorded in 5 (10%). Flat urethral plate was recorded in 20 with 12 showing POST ratio >1.2 and 8 had <1.2. Narrow urethral plate was recorded in 25 with 15 showing POST ratio of >1.2 while 10 had <1.2. In all patients of POST ratio <1.2, ventral migration of dorsal end of glans meatus was present.

Conclusions:
Only 10% of hypospadias match the configuration of experimentally created hypospadias and are suitable for classic TIP. Patients with narrow urethral plates are suitable for TIP with the inclusion of paraurethral plate penile skin strip. All categories with POST score <1.2 are suitable for TIP with inner prepucial graft in incised glans bed and incised urethral plate.
Interstitial Cells of Cajal and Ganglion Cell Distribution in Sigmoid Stomal Limbs and Distal Rectum after Stoma Formation in Male Anorectal Malformation Patients Undergoing Staged Repair
Authors: Bamoria Priyanka , Ratan Simmi K. , Panda Shasanka Shekhar , Neogi Sujoy , Mandal Shramana , Kumar Chiranjiv , Saxena Gaurav 
Published: January 2025

ABSTRACT

Introduction:
This study was undertaken to assess the distribution of ganglion cells (GCs) and interstitial cells of Cajal (ICCs) across different points of distal rectal pouch in anorectal malformation (ARM) patients over the three stages of repair. We hypothesize that along with the surgical factors, there could be intrinsic factors as well which can be the cause of dysmotility in these patients after surgical repair.

Methodology:
Full-thickness colonic biopsy specimens were taken from the proximal stoma, distal stoma, and distal rectal pouch of 21 boys aged 0–8 months undergoing 3 staged repair of ARM at our tertiary care center between August 2022 and December 2023. There was an interstage interval of approximately 12–14 weeks. All underwent high-divided sigmoid colostomy in stage 1. Biopsy specimens for GC and ICC number were routinely processed, and immunohistochemistry was done for CD117. The data was assessed and compared with respect to location and stage of surgery.

Results:
Both GC and ICC showed a gradual decrease in mean number over three stages for both proximal and distal ends of colostomy. For proximal stoma, the distribution of either cell type did not differ across the stages, but for distal stoma, the number of cells was significantly lower in the second stage (following colostomy, before posterior sagittal anorectoplasty). However, no difference was noted between the second and third stages. This indicates that factors during/just after colostomy itself must be responsible for decrease in ICC/GC.

Conclusion:
Lesser number of GC and/or ICC in the distal pouch from stage 2 onward may point toward its association with projected hypomotility in ARM patients. Apart from innate distribution, we also infer that this could be consequent to vascular insult which may occur at the time of divided colostomy. Loop stoma may be a better alternative as vascularity is uninterrupted in loop colostomy.
CXCL13 levels in cerebrospinal fluid in relapsing-remitting multiple sclerosis: The role of Borrelia in neuroinfections
Authors: Karabörk Şeyda , Türkoğlu Şule Aydin , Yildiz Serpil , Sirmatel Fatma 
Published: January 2025

Background & objectives:
This study was compared the Borrelia antibodies and chemokine ligand 13 (CXCL13) levels in cerebrospinal fluid (CSF) samples from cases diagnosed with relapsing-remitting multiple sclerosis (RRMS), radiologically isolated syndrome (RIS), and pseudotumour cerebri (PTC).

Methods:
A total of 43 CSF samples were collected from patients diagnosed with RRMS, RIS and PTC. We prospectively investigated Borrelia IgG and IgM antibodies in the CSF samples of the cases by enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) method, and CXCL13 levels by ELISA. Data were statistically analysed using the the Spearman rank correlation test.

Results:
Five antigens (protein 19, 20, 21, 58, and outer surface protein C (OspC)) were positive due to confirmation of the positive samples for Borrelia antibodies by the WB method. There were no significant differences in CSF CXCL13 levels between the three groups. The CXCL13 level was found to be statistically higher in the demyelinating group compared to the PTC group (p=0.001).

Interpretation & conclusion:
The Borrelia antibodies were found positive in CSF samples of RRMS patients. The coexistence of high CXCL13 (may be a potential biomarker) suggests that LNB may also play a role in the etiopathogenesis of RRMS. In addition, the positive detection of OspC and p58 WB bands in most cases suggests that these protein bands can be used as in the differential diagnosis of neurodegenerative diseases and Lyme disease.
Evaluation of the transcrestal sinus elevation using simple lift kit with simultaneous grafting and implant placement
Authors: Emera Ahmed Nabil Saad Abo , Khalifa Mahmoud El-sayed , Sadakah Abd E.A. Elmongy , Ibrahim Marwa Taha 
Published: January 2025

Abstract

Background
Rehabilitation of the edentulous maxilla with dental implants is challenging. The transcrestal sinus elevation procedure has become an important preprosthetic surgical procedure for bone creation in the posterior maxilla with implant placement.

Purpose
This study was planned to evaluate the success of transcrestal sinus elevation using a simple lift kit with simultaneous grafting and placement of implant.

Patients and methods
A randomized clinical trial was conducted on ten patients with bone height below the floor of the maxillary sinus ranged from 5 to 8 mm, which was indicated for sinus membrane elevation using the simple lift kit. After preparation of the implant site and osteotomy, sinus membrane elevation using the simple lift kit and augmentation using bovine bone with the implant placement using surgical guide were done simultaneously. Osseointegration and bone height were measured using cone beam computed tomography after 6 months.

Results
Successful sinus membrane grafting using simple lift kit procedures was performed in 10 cases without sinus membrane perforation. A total of 10 implants were placed. The radiographic examination showed the bone height before and after sinus membrane lift was statistically significant, as there the increase in bone height ranged from 2.4 to 4.8 mm.

Conclusion
The simple lift kit is a minimally invasive technique, associated with very little discomfort and complications, which allows greater control and safety when performing the elevation of the sinus membrane.
Marginal seal of class V restorations using thermoviscous and sonic-fill bulk fill composites
Authors: Ghobashy Amira Magdy , Elmarhomy AL-Zahraa M. , Elsayed Hussein Y. 
Published: January 2025

Abstract

Aim
To investigate the cervical and occlusal marginal seal of class V restorations using thermoviscous, sonic-fill bulk-fill and conventional SDR flowable bulk-fill composites.

Materials and methods
Standardized class V cavities were prepared in 45 extracted sound human molars that were randomly divided into three equal groups (n = 15) according to the restorative material used. This was divided as follow: group I (Surefil SDR flowable bulk-fill composite), group II (VisCalor bulk-fill composite), and group III (Sonic-fill 2 composite). Each restoration was applied according to the manufacturer’s instructions. All the specimens were subjected to 500 thermocyclings then were immersed in 2% methylene blue dye and sectioned to detect extend of the dye penetration using stereomicroscope. The data were collected, tabulated, and statistically analyzed using SPSS, version 26.

Results
There was no significant difference between the three tested groups in both occlusal and cervical marginal adaptation. However, a statistically significant difference was observed between group I which recorded a higher mean score of microleakage versus group II with P value = 0.059 at the occlusal walls. Concerning the comparison between occlusal and cervical dye penetration, it was found that there was no significant difference in both group I and group III. While in group II the occlusal margins had a lower mean score values of microleakage than the cervical walls with statistically significant difference (P = 0.053).

Conclusion
All the tested materials presented nearly comparable occlusal and cervical marginal adaptation results. However, VisCalor bulk-fill composite enhanced the cervical marginal adaptation compared the occlusal margins.
Evaluation of patients’ knowledge about their rights and responsibilities at Kafr El-Sheikh University
Authors: Sabry Marwa Mohamed 
Published: January 2025

Abstract

Introduction
The American Dental Association has emphasized the importance of patients being aware of their rights and responsibilities. These responsibilities include providing accurate medical history information, reporting any changes, communicating desires and expectations, participating in healthcare decisions, and speaking out if unsure about dental prescriptions or approaches.
This study aimed to evaluate patients’ knowledge of their rights and responsibilities at Kafr El-Sheikh University.

Methods
A cross-sectional study was conducted at Kafr El-Sheikh University Clinics starting in March 2024. A structured interview administered by the researcher was used to gather data from the patients. The questionnaire consisted of three sections: socio-demographic variables (sex, education, income), knowledge of patients’ rights, and patients’ responsibilities.

Results
The results showed that all patients (100%) were aware of their responsibility to maintain regular oral healthcare routines at home and to fulfill financial obligations towards healthcare. However, 74.9% of respondents were unaware of their responsibility for the consequences of declining treatment or not following the agreed-upon treatment plan.

Conclusions
The study concluded that patients had insufficient knowledge of their rights and responsibilities. It was also observed that patients’ knowledge of their rights and responsibilities increased with higher income and education levels.
Antimicrobial effect of different concentrations of zirconium dioxide versus titanium dioxide nanoparticles incorporated in conventional polymethylmethacrylate denture base: A randomized clinical trial
Authors: Borg Hesham S. , Mostafa Tamer M.N. 
Published: January 2025

Abstract

Purpose
To compare the antimicrobial effect and reveal out the most effective concentration of zirconium dioxide (ZrO2) and titanium dioxide (TiO2) nanoparticles added to polymethylmethacrylate (PMMA) denture bases.

Patients and methods
Forty completely edentulous male patients with mean age of 48 years old randomly distributed into five groups (eight patients each): group I received PMMA dentures without additives, group II received 1% ZrO2 nanoparticles PMMA dentures, group III received 3% ZrO2 nanoparticles PMMA dentures, group VI received 1% TiO2 nanoparticles PMMA dentures, and group V received 3% TiO2 nanoparticles PMMA dentures. Microbiological evaluation concerning Candida albicans was performed from the fitting surface of dentures after 1 week, 2 weeks, and 1 month of denture delivery. Data were delivered, tabulated, and statistically analyzed using analysis of variance test followed by Tukey’s post-hoc test at a significance level of 5%.

Results
No statistical significant differences were found between the study groups (P ≥ 0.05) but all groups showed statistical significant difference with the control group (P < 0.05).

Conclusions
Although the limitations and results of this study; 3% TiO2 and 3% ZrO2 nanoparticles give the PMMA denture base the most powerful antimicrobial effect.
Evaluation of endo-crowns retention before and after radiotherapy
Authors: El-Sayed Abeer Shawky , Massoud Gaber I. , El-Dessouky Radwa A. , Aldesoky Amira I. 
Published: January 2025

Abstract

Objectives
This study aimed to evaluate endo-crowns retention before and after radiotherapy.

Materials and Methods
Thirty endodontically treated human molars were divided into three groups according to exposure to radiotherapy: group I (control group), group II (cemented before radiotherapy) and group III (cemented after radiotherapy). Specimens were prepared to receive endo-crowns using computerized numerical control milling machine with the following criteria: occlusal reduction parallel to the occlusal plane (butt joint) 1 mm above cemento–enamel junction, axial preparation with 8° total occlusal convergence, 3 mm pulpal floor depth and trapezoid shape pulp-chamber cavity. The pulpal orifices and undercuts in mesial and distal canals were protected with flowable composite. After cementation with Theracem cement, evaluation of retention of endo-crowns was performed using pull-out test on universal testing machine along the long axis of teeth at constant loading rate of 0.5 mm/min and the forces will be recorded at the point of dislodgment of endo-crown in newton.

Result
Irradiated groups recorded lower bond strength values than nonirradiated group. There is a highly significant difference between group I (control group) and group II (before radio group) with P value 0.000, also there is a highly significant difference between group I (control group) and group III (after radio group) with P value 0.000, since there is a significant difference between group II and group III.

Conclusion
Radiotherapy had a negative effect on retention of endo-crowns cemented before and after radiotherapy.