bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Sensitivity Kernels With Full Attenuation Computed by a Combination of the Strong Stability Preserving Runge‐Kutta Method and the Scattering‐Integral Method
Authors: Wang Nian , Yang Dinghui , Shen Yang , Bao Xueyang , Li Jiahang 
Published: August 2023

AbstractTo date developments of seismic attenuation models of the Earth have lagged those of velocity models. This is partly due to difficulties in isolating waveform perturbations caused by attenuation and velocity heterogeneities and partly due to different theories (e.g., ray theory, finite frequency theory) used in most previous and current studies to approximate sensitivity kernels and invert for the attenuation structure. We present in this paper a new method for computing the 3D waveform Fréchet kernels that account for full physical‐dispersion and dissipation attenuation. For solving the 3D isotropic anelastic wave equation described by the generalized Maxwell body model, we extend our previously proposed full waveform modeling method in Cartesian coordinates to that in spherical coordinates, which can provide stable numerical solutions even in the presence of strong attenuation. Then, we apply the scattering‐integral method for calculating 3D travel time and amplitude sensitivity kernels with respect to velocity and attenuation structures. We demonstrate the accuracy of our forward method and the effectiveness of the implementation of absorbing and free surface boundary conditions through numerical tests. Moreover, by choosing the Northwestern United States region as a realistic example, we verify the accuracy of the computed 3D sensitivity kernels through comparing the waveform measurements with predictions from the kernels. Finally, we discuss the importance of calculating full anelastic sensitivity kernels including both effects of physical dispersion and dissipation, where we specially explore the effect of scattering due to random velocity and attenuation heterogeneities on waveform measurements.
On the Formation of Global Inter‐Source Correlations and Applications to Constrain the Interiors of the Earth and Other Terrestrial Planets
Authors: Wang Sheng , Tkalčić Hrvoje 
Published: August 2023

AbstractThe cross‐correlation stack of earthquake late‐coda between seismic receivers on a global scale—global inter‐receiver correlogram—exhibits numerous features that provide information on the Earth's structure. The cross‐correlation stack between seismic sources (global inter‐source correlogram) can also be constructed, and, in theory, it should reproduce the correlation features seen in the inter‐receiver correlogram. However, practical attempts at global inter‐source correlograms have not produced the theoretical expectations. Namely, the obtained inter‐source correlograms are void of discernible correlation features. Here, we address this problem and document the steps that have to be undertaken to produce the inter‐source global correlogram with the equivalent abundance of correlation features. We show that forming inter‐source correlation features requires constructive contributions determined by specific source mechanisms and source‐receiver geometries. They are overwhelmed by destructive contributions if seismic records of all available sources and source‐receiver geometries are used. Building upon that, we present an effective procedure for constructing global inter‐source correlations through a rigorous selection of source mechanisms and source‐receiver geometries. The resulting inter‐source correlations exhibit numerous prominent correlation features as predicted. Notably, this method enables the construction of global inter‐source correlations in a special case with a single seismic receiver. Furthermore, we explore and demonstrate the feasibility of utilizing single‐receiver inter‐source correlations to constrain the interiors of the Earth and other terrestrial bodies. Our study facilitates practical applications of global inter‐source correlations, providing additional constraints on the Earth's structure and offering an effective routine to probe the interiors of other planets and moons using currently affordable resources.
A Comparison Study of Mg/Ca‐, Alkenone‐, and TEX86‐Derived Temperatures for the Brazilian Margin
Authors: Bahr A. , Jaeschke A. , Hou A. , Meier K. , Chiessi C. M. , Albuquerque A. L. Spadano , Rethemeyer J. , Friedrich O. 
Published: August 2023

AbstractThe reconstruction of accurate sea‐surface temperatures (SST) is of utmost importance due to the ocean's central role in the global climate system. Yet, a number of environmental processes might bias reliable SST estimations. Here, we investigate the fidelity of SST reconstructions for the western tropical South Atlantic (WTSA) for the interval covered by Marine Isotope Stages (MIS) 6–5, utilizing a core collected off eastern Brazil at ∼20°S. This interval was selected as previous SST estimates based on Mg/Ca ratios of planktic foraminifera suggested a peculiar pooling of warm surface waters in the WTSA during MIS 6 despite glacial boundary conditions. To ground‐truth the Mg/Ca‐based SST data we generated SST reconstructions on the same core material using the alkenone and TEX86 paleothermometers. Comparison with alkenone‐based temperature estimates corroborate the previous Mg/Ca‐based SST reconstructions, supporting the suggestion of a warm‐water anomaly during MIS 6. In contrast, TEX86‐derived temperatures, albeit representing annual mean SST in recent core top samples, are up to 6°C colder than Mg/Ca‐ and alkenone‐based SST reconstructions. We interpret the periods of anomalously cold TEX86‐temperatures as a result of a vertical migration of the TEX86 producers (heterotrophic marine Thaumarchaeota) toward greater water depths, following food availability during phases of enhanced fluvial suspension input. Likewise, the data suggest that alkenone‐based SST are, albeit to a minor degree when compared to TEX86, affected by river run‐off and/or a seasonal bias in the growth season of haptophyte algae.
Chasing Interannual Marine Paleovariability
Authors: Thirumalai Kaustubh , Maupin Christopher R. 
Published: August 2023

AbstractSeveral modes of tropical sea‐surface temperature (SST) variability operate on year‐to‐year (interannual) timescales and profoundly shape seasonal precipitation patterns across adjacent landmasses. Substantial uncertainty remains in addressing how SST variability will become altered under sustained greenhouse warming. Paleoceanographic estimates of changes in variability under past climatic states have emerged as a powerful method to clarify the sensitivity of interannual variability to climate forcing. Several approaches have been developed to investigate interannual SST variability within and beyond the observational period, primarily using marine calcifiers that afford subannual‐resolution sampling plans. Amongst these approaches, geochemical variations in coral skeletons are particularly attractive for their near‐monthly, continuous sampling resolution, and capacity to focus on SST anomalies after removing an annual cycle calculated over many years (represented as geochemical oscillations). Here we briefly review the paleoceanographic pursuit of interannual variability. We additionally highlight recent research documented by Ong et al., (2022, https://doi.org/10.1029/2022PA004483) who demonstrate the utility of Sr/Ca variations in capturing SST variability using a difficult‐to‐sample meandroid coral species, Colpophyllia natans, which is widespread across the Caribbean region and can be used to generate records spanning multiple centuries.
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
Authors: Zhang Xinchao , Zhang Yue , Wang Chaofu , Wang Xu 
Published: August 2023

AbstractTen-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3, can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxycytosine (5caC), and then two of these intermediates (5fC and 5caC) can be excised and return to unmethylated cytosines by thymine-DNA glycosylase (TDG)-mediated base excision repair. Because DNA methylation and demethylation play an important role in numerous biological processes, including zygote formation, embryogenesis, spatial learning and immune homeostasis, the regulation of TETs functions is complicated, and dysregulation of their functions is implicated in many diseases such as myeloid malignancies. In addition, recent studies have demonstrated that TET2 is able to catalyze the hydroxymethylation of RNA to perform post-transcriptional regulation. Notably, catalytic-independent functions of TETs in certain biological contexts have been identified, further highlighting their multifunctional roles. Interestingly, by reactivating the expression of selected target genes, accumulated evidences support the potential therapeutic use of TETs-based DNA methylation editing tools in disorders associated with epigenetic silencing. In this review, we summarize recent key findings in TETs functions, activity regulators at various levels, technological advances in the detection of 5hmC, the main TETs oxidative product, and TETs emerging applications in epigenetic editing. Furthermore, we discuss existing challenges and future directions in this field.
HSPA12A controls cerebral lactate homeostasis to maintain hippocampal neurogenesis and mood stabilization
Authors: Wang Jialing , Lu Ting , Gui Yali , Zhang Xiaojin , Cao Xiaofei , Li Yuehua , Li Chuanfu , Liu Li , Ding Zhengnian 
Published: August 2023

AbstractMood instability, a subjective emotional state defined as rapid mood oscillations of up and down, is a symptom that occurs in several psychiatric disorders, particularly major depressive disorder and bipolar disorder. Heat shock protein A12A (HSPA12A) shows decreased expression in the brains of schizophrenia patients. However, the causal effects of HSPA12A in any psychiatric disorders are completely unknown. To investigate whether HSPA12A affects mood stability, Hspa12a-knockout mice (Hspa12a−/−) and wild-type (WT) littermates were subjected to tests of open field, forced swimming, elevated plus maze, and sucrose preference. Cerebral lactate levels were measured in cerebrospinal fluid (CSF). Adult hippocampal neurogenesis (AHN) was assessed by BrdU labeling. We found that acute mood stress increased hippocampal HSPA12A expression and CSF lactate levels in mice. However, Hspa12a−/− mice exhibited behaviors of mood instability (anhedonia, lower locomotor activity, antidepression, and anxiety), which were accompanied by impaired AHN, decreased CSF lactate levels, and downregulated hippocampal glycolytic enzyme expression. By contrast, HSPA12A overexpression increased lactate production and glycolytic enzyme expression of primary hippocampal neurons. Intriguingly, lactate administration alleviated the mood instability and AHN impairment in Hspa12a−/− mice. Further analyses revealed that HSPA12A was necessary for sustaining cerebral lactate homeostasis, which could be mediated by inhibiting GSK3β in hippocampal neurons, to maintain AHN and mood stabilization. Taken together, HSPA12A is defined as a novel regulator of mood stability and exerts therapeutic potential for mood disorder. Our findings establish a framework for determining mood disorder and AHN relevance of cerebral lactate homeostasis.
Record-matching of STR profiles with fragmentary genomic SNP data
Authors: Kim Jaehee , Rosenberg Noah A. 
Published: August 2023

AbstractIn many forensic settings, identity of a DNA sample is sought from poor-quality DNA, for which the typical STR loci tabulated in forensic databases are not possible to reliably genotype. Genome-wide SNPs, however, can potentially be genotyped from such samples via next-generation sequencing, so that queries can in principle compare SNP genotypes from DNA samples of interest to STR genotype profiles that represent proposed matches. We use genetic record-matching to evaluate the possibility of testing SNP profiles obtained from poor-quality DNA samples to identify exact and relatedness matches to STR profiles. Using simulations based on whole-genome sequences, we show that in some settings, similar match accuracies to those seen with full coverage of the genome are obtained by genetic record-matching for SNP data that represent 5–10% genomic coverage. Thus, if even a fraction of random genomic SNPs can be genotyped by next-generation sequencing, then the potential may exist to test the resulting genotype profiles for matches to profiles consisting exclusively of nonoverlapping STR loci. The result has implications in relation to criminal justice, mass disasters, missing-person cases, studies of ancient DNA, and genomic privacy.
Chronic comorbid conditions and asthma exacerbation occurrence in a general population sample
Authors: Baljet Emma , Luijks Hilde , van den Bemt Lisette , Schermer Tjard R. 
Published: August 2023

AbstractChronic comorbid conditions are common in adults with asthma, and some may influence a patient’s asthma exacerbation risk. We explored associations between eighteen chronic comorbid conditions and asthma exacerbation occurrence in adults with asthma in a cross-sectional study nested within a cohort study using data from the two-yearly US National Health and Nutrition Examination Survey (NHANES) program. Data of 2387 adults with self-reported doctor-diagnosed current asthma from the 2007 to 2018 NHANES surveys were selected. Investigated chronic comorbidities were: angina pectoris; congestive heart failure; coronary heart disease; depression; diabetes mellitus; soft and hard drug use; gastroesophageal reflux; gout; history of heart attack; history of stroke; hypercholesterolemia; hypertension; kidney failure; liver conditions; obesity; rheumatoid arthritis; and thyroid problems. Outcome was defined as asthma exacerbation category: no, moderate, or severe exacerbation(s) in the past year. Ordinal logistic regression analysis with correction for potential confounders was used to estimate odds ratios (OR) for moderate or severe exacerbations. Observed associations with increased severe asthma exacerbation occurrence were: obesity (OR = 1.67; 95% confidence interval 1.24, 2.26), and rheumatoid arthritis (OR = 1.55; 1.04, 2.30). History of stroke (OR = 1.95; 1.22, 3.11) and rheumatoid arthritis (OR = 1.33; 1.00, 1.75) showed associations with increased moderate exacerbation occurrence. Age-stratified analysis showed soft drug use, obesity, depression, thyroid problems, and rheumatoid arthritis to be associated with moderate and/or severe exacerbation occurrence in one or more 10-year age strata. In conclusion, several chronic comorbid conditions were associated with asthma exacerbation occurrence, which confirms but also complements previous studies. Our observations contribute to understanding exacerbation risk estimation and, ultimately, personalized asthma management.
Ecological, social, and intrinsic factors affecting wild orangutans’ curiosity, assessed using a field experiment
Authors: Schuppli Caroline , Nellissen Lara , Carvajal Luz , Ashbury Alison M. , Oliver-Caldwell Natalie , Rahmaeti Tri , Laumer Isabelle , Haun Daniel 
Published: August 2023

AbstractThe readiness to interact with and explore novel stimuli—i.e., curiosity—is the cornerstone of innovation. Great apes show broad and complex innovation repertoires. However, little is known about the factors that affect curiosity in wild apes. To shed light on wild apes’ curiosity, we measured the reactions of wild Sumatran orangutans (Pongo abelii) to an experiment apparatus. Overall, individuals were reluctant to touch the apparatus. However, compared to adults, immatures showed higher tendencies to explore (measured through looking durations and the probability of touching the apparatus) and to approach (measured through approach latencies and approach distances) the apparatus but were more likely to show behavioral signs of agitation. The presence of conspecifics who approached the apparatus increased visual exploration and approach tendencies. Prevailing habitat food availability positively affected visual exploration but had a negative effect on approach tendencies. These findings indicate that intrinsic, social, and ecological factors affect reactions to novelty in wild orangutans and suggest that exploration, neophobia and neophilia are independently regulated. Because reactions to novelty can be an essential pathway to innovation, our results suggest that factors acting on different elements of curiosity must be considered to understand the evolution of innovative tendencies.
Tribological properties of high-speed steel surface with texture and vertical fibers
Authors: Feng Kai , Ni Jing , Wang Zixuan , Meng Zhen 
Published: August 2023

AbstractInadequate lubrication of the two touching surfaces during friction can lead to severe wear, especially in metal cutting. Therefore, a surface with synergistic anti-friction effect of texture and solid lubricant was proposed to improve lubrication. A mesh texture with excellent wettability was prepared on the high-speed steel (HSS) surface by laser, and then nylon fibers were vertically implanted into the grooves of the texture using the electrostatic flocking technology. The friction and wear state of different surfaces (smooth, textured, flocking) under dry/oil-lubricated were studied by a linear reciprocating wear tester. The coefficient of friction (COF) under different working conditions was used to analyze the anti-friction properties, and the wear rate was used to evaluate the wear resistance of the surface. The results showed that the tribological properties of flocking surfaces were better than those of the other two surfaces. This is because the addition of nylon fibers eases shear at the edges of the texture. The broken fibers form a solid lubricating film on the specimen surface, which prevents the surface from being scratched by debris. In addition, it is found that COF decreases with increasing load. Finally, the rapid wettability of the oil droplets on the flocking surface shows the great potential of the surface for lubrication and anti-friction.
IgG persistence showed weak clinical aspects in chronic schistosomiasis patients
Authors: Xie Shudong , Zhang Yu , Li Junhui , Zhou Jie , Li Jun , Zhang Pengpeng , Liu Yang , Luo Yulin , Ming Yingzi 
Published: August 2023

AbstractSchistosomiasis is a chronic parasitic disease, which affects the quality of daily life of patients and imposes a huge burden on society. Hepatic fibrosis in response to continuous insult of eggs to the liver is a significant cause of morbidity and mortality. However, the mechanisms of hepatic fibrosis in schistosomiasis are largely undefined. The purpose of our study is to detect the indicator to hepatic fibrosis in schistosomiasis. A total of 488 patients with chronic schistosomiasis japonica were enrolled in our study. The patients were divided into two groups according to liver ultrasound examination, which could indicate liver fibrosis of schistosomiasis with unique reticular changes. Logistic regression analysis showed that globulin, albumin/globulin, GGT levels and anti-Schistosoma IgG were independently associated with liver fibrosis in patients with schistosomiasis and IgG was the largest association of liver fibrosis (OR  2.039, 95% CI 1.293–3.213). We further compared IgG+ patients with IgG− patients. IgG+ patients (ALT 25 U/L, GGT 31 U/L) slightly higher than IgG− patients (ALT 22 U/L, GGT 26 U/L) in ALT and GGT. However, the fibrosis of liver in IgG+ patients (Grade II(19.7%), Grade III(7.3%)) were more severe than that in IgG− patients(Grade II(12.5%), Grade III(2.9%)) according to the grade of liver ultrasonography. Our results showed anti-Schistosoma IgG was independently associated with liver fibrosis in patients with chronic schistosomiasis japonica and patients with persistent anti-Schistosoma IgG might have more liver fibrosis than negative patients despite no obvious clinical signs or symptoms.
Mechanical hierarchy in the formation and modulation of cortical folding patterns
Authors: Chavoshnejad Poorya , Vallejo Liam , Zhang Songyao , Guo Yanchen , Dai Weiying , Zhang Tuo , Razavi Mir Jalil 
Published: August 2023

AbstractThe important mechanical parameters and their hierarchy in the growth and folding of the human brain have not been thoroughly understood. In this study, we developed a multiscale mechanical model to investigate how the interplay between initial geometrical undulations, differential tangential growth in the cortical plate, and axonal connectivity form and regulate the folding patterns of the human brain in a hierarchical order. To do so, different growth scenarios with bilayer spherical models that features initial undulations on the cortex and uniform or heterogeneous distribution of axonal fibers in the white matter were developed, statistically analyzed, and validated by the imaging observations. The results showed that the differential tangential growth is the inducer of cortical folding, and in a hierarchal order, high-amplitude initial undulations on the surface and axonal fibers in the substrate regulate the folding patterns and determine the location of gyri and sulci. The locations with dense axonal fibers after folding settle in gyri rather than sulci. The statistical results also indicated that there is a strong correlation between the location of positive (outward) and negative (inward) initial undulations and the locations of gyri and sulci after folding, respectively. In addition, the locations of 3-hinge gyral folds are strongly correlated with the initial positive undulations and locations of dense axonal fibers. As another finding, it was revealed that there is a correlation between the density of axonal fibers and local gyrification index, which has been observed in imaging studies but not yet fundamentally explained. This study is the first step in understanding the linkage between abnormal gyrification (surface morphology) and disruption in connectivity that has been observed in some brain disorders such as Autism Spectrum Disorder. Moreover, the findings of the study directly contribute to the concept of the regularity and variability of folding patterns in individual human brains.