bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abemaciclib pharmacovigilance analysis：a real-world analysis of post-marketing surveillance Data
Authors: Dong Zhu , Wang Zejun , Dong Weizheng , Li Weizheng 
Published: April 2023

Abstract
Background
Abemaciclib is currently the most active Cyclin4/6-dependent kinase inhibitor (CDKI) for the treatment of estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative(HER2−) advanced breast cancer. We explored the potential adverse reactions of Abemaciclib by mining the relevant reported data and tried to provide information for the clinical safe medication.
Methods
Reporting odds ratio (ROR) was used to detect adverse event signals from the data in the US Food and Drug Administration (FDA) adverse event reporting system database (FAERS). The definition depended on preferred terms (PTs) and system organ class (SOCs) by the Medical Dictionary for Regulatory Activities (MedDRA).
Results
A total of 5680 reports and 12170 adverse events were retrieved, 55 alert signals were excavated. Among them, the strong signals were "weight decreased”, “blood creatinine increased”, “constipation”, “stomatitis”, “pleural effusion”, “pneumothorax”, ”hot flashes”, ”hypokalemia”, “blood potassium decreased”, “taste disorder”, “eating disorder”, ”renal impairment”, “kidney disease” and “lacrimation increased”. We found that “eating disorder”, “hot flush” and ”pleural effusion” are some new safety signals. The system organ class (SOC) involved in the highest frequency signals mainly focused on abnormal examination parameters and gastrointestinal system diseases.
Conclusions
Overall, by using the FDA FAERS the present study suggested some new safety signals, which deserve more careful monitoring in clinic.
Iodine Nutrition: Iodine content in iodized salt in Sri Lanka and the effect of temperature and storage conditions on the stability
Authors: Hettiarachchi H. H. K. A. P. K. , Premachandre G. M. G. C. K. , Jayasundera A. C. A. , Satharasinghe D. A. , Wanigasekera W. M. A. P. 
Published: April 2023

Abstract
Background
The major source of dietary iodine for the Sri Lankan population is iodized salt. The recommended fortification level of iodine is 15.0–30.0 ppm. Both excessive and insufficient iodine levels are harmful to the human body. Inadequate consumption of iodine leads to iodine deficiency disorders and excessive intake causes iodine-induced hyperthyroidism.
Methods
This study assessed the iodine content in commercially available salt products and evaluated the stability of iodine under different storage conditions. Packeted crystal and powdered salt products were used to determine the total iodine content by analyzing both iodide (I−) and iodate (IO3−). The effect of temperature and packaging material on the stability of iodine was also recorded.
Results
The results revealed that five products out of ten exceeded the recommended iodine level and were in the range of 31.60 ± 1.5 to 42.19 ± 3.48 ppm. The iodine content of four products was within the recommended fortified levels, and one had a lower amount of 12.77 ± 0.35 ppm. The mean iodine content of powdered salt was 35.08 ppm and 27.25 ppm in crystal salt. There was no significant effect of temperature at 25°C, 45°C, and 95°C on total iodine level and iodine level by iodate. The total mean iodine loss after heating to 95°C for 30 minutes was 5.0% in powdered salt and 8.7% in crystal salts. Total iodine retained during storage in opened containers for one week in glass containers was 90.78% in crystal salt and 87.11% in powdered salt. The percentage of iodine retained in plastic containers was 83.77% in crystal salt and 71.6% in powdered salt. In coconut shell containers 61.94% and 49.23% iodine retained was observed in crystal salt and powdered salt respectively. The lowest iodine retain was in gunny bags 54.24% in crystal salt and 44.77% in powdered salt.
Conclusions
Most of the commercially available salt products (50%) contain a higher amount of iodine than the recommended fortification levels. Short-term exposure of iodized salt to cooking temperatures and in different storage containers didn’t show any remarkable reduction in the levels of iodine.
A multi-response sensor based on a bat-like Zn(II) coordination polymer: synthesis, structure and ‘turn off’ sensing of TC, Fe3+ and AA in aqueous system
Authors: Zhang Ya-Tong , Wang Ai , Feng Si-Si , Yuan Cai-Xia , Lu Li-Ping 
Published: April 2023

Abstract
A new 2D homochiral zinc coordination polymer (Zn-CP) with 52-member rings was synthesized by solvothermal method. X-ray single crystal diffraction results show that the initial ligand (H2ibga = (4-(1H-imidazol-1-yl)benzyl)-L-glutamic acid) cyclized and crystallized in monoclinic with space group P2 after coordination with zinc(II) ions. Phase purity and thermal stability of Zn-CP were verified by X-ray powder diffraction (PXRD) and thermogravimetric (TG), respectively. Additionally, Zn-CP can recognize tetracycline (TC), Fe3+ and ascorbic acid (AA) rapidly and selectively in aqueous solution, with low detection limits (LODs) of 3.49 nM, 4.42 nM and 0.38 µM, respectively. The detection mechanisms have been investigated in detail.
Genetic contributions of noncognitive skills to academic development
Authors: Malanchini Margherita , Allegrini Andrea , Nivard Michel G , Biroli Pietro , Rimfeld Kaili , Cheesman Rosa , von Stumm Sophie , Demange Perline , Bergen Elsje van , Grotzinger Andrew , Raffington Laurel , Fuente Javier de la , Pingault Jean-Baptiste , Harden K , Tucker-Drob Elliot , Plomin Robert 
Published: April 2023

Abstract

Noncognitive skills such as motivation and self-regulation, predict academic achievement beyond cognitive skills. However, the role of genetic and environmental factors and of their interplay in these developmental associations remains unclear. We provide a comprehensive account of how cognitive and noncognitive skills contribute to academic achievement from ages 7 to 16 in a sample of >10,000 children from England and Wales. Results indicated that noncognitive skills become increasingly predictive of academic achievement across development. Triangulating genetic methods, including twin analyses and polygenic scores (PGS), we found that the contribution of noncognitive genetics to academic achievement becomes stronger over development. The PGS for noncognitive skills predicted academic achievement developmentally, with prediction nearly doubling by age 16, pointing to gene-environment correlation (rGE). Within-family analyses indicated both passive and active/evocative rGE processes driven by noncognitive genetics. By studying genetic effects through a developmental lens, we provide novel insights into the role of noncognitive skills in academic development.
Brief Report: Children with a history of both maternal immune activation and prematurity are not at increased risk of ADHD
Authors: Ellul Pierre , Wallez Solène , Acquaviva Eric , Rosenzwajg Michelle , Klatzmann David , Delorme Richard , Melchior Maria 
Published: April 2023

Abstract
Maternal autoimmune diseases (AID) are risk factors for Attention Deficit Hyperactivity Disorder (ADHD). Animal studies suggest that maternal immune activation (MIA) is a disease primer for ADHD, with second environmental factor precipitating the onset of the disease. Prematurity is also a major risk factor for ADHD. In this study, we sought to explore the interaction between parental AID and prematurity on ADHD risk in a community sample. Children of AID parents born prematurely appeared at increased odds of ADHD but but these two risk factors do not appear to be additive (OR: 1.39 [95 CI 0.75; 2.46]). Longitudinal studies with larger numbers of participants are needed.
Whole-Body Photobiomodulation Therapy for Fibromyalgia: A Feasibility Trial
Authors: Fitzmaurice Bethany C. , Heneghan Nicola R. , Rayen Asius T.A. , Grenfell Rebecca L. , Soundy Andrew A 
Published: April 2023

Abstract
Background
Effective treatment for fibromyalgia (FM) is lacking and further treatment options are needed. Photobiomodulation therapy (PBMT) represents one potential treatment option. Whilst favourable findings have been reported using localised PBMT, no investigations have established the value of whole-body PBMT for the complete set of symptom domains in FM.
Methods
A single-arm feasibility study was conducted in accordance to CONSORT (CONsolidated Standards of Reporting Trials) guidelines. A non-probability sampling method was used to access individuals with FM. The primary outcome measure was identified as the Revised Fibromyalgia Impact Questionnaire (FIQR). Forty-nine participants were screened and 21 trial participants entered the trial. Nineteen participants completed the intervention (18 whole-body PBMT sessions over approximately six weeks). Descriptive statistics and qualitative analysis was undertaken to represent feasibility outcomes. Acceptability of the trial device and processes were established. Outcome measures towards efficacy data were guided by core and peripheral OMERACT (outcomes measures in rheumatological clinical trials) domains, utilising a combination of participant-reported and performance-based outcome measures. Data for the embedded qualitative component of the trial were captured by participant-reported experience measures and audio-recorded semi-structured interviews.
Results
Positive changes were observed for FM-specific quality of life, pain, tenderness, stiffness, fatigue, sleep disturbance, anxiety, depression and cognitive impairment. Patient global assessment revealed improvements at 6 weeks, with continued effect at 24 weeks. FM-specific quality of life at 24 weeks remained improved compared with baseline scores.
Conclusions
Findings provide evidence to support a full-scale trial and shows promise regarding potential efficacy of this novel non-invasive treatment in an FM population.
Trial Registration
ClinicalTrials.gov trial; NCT05069363, 06/10/2021
Glymphatic improves inflammation and apoptosis after cerebral ischemia-reperfusion injury in mice through ERK signaling pathway
Authors: Li Xiaohong , Xie Zhuoxi , Zhou Qian , Tan Xiaoli , Meng Weiting , Pang Yeyu , Huang Lizhen , Ding Zhihao , Hu Yuanhong , Li Ruhua , Huang Guilan , Li Hao 
Published: April 2023

Abstract
Background
The acute inhibition of glymphatic after stroke has been shown to aggravate post-stroke inflammation and apoptosis; however, the related mechanisms remain ambiguous. This study aimed to assess the specific mechanism of inflammation and apoptosis after cerebral ischemia-reperfusion (I/R) injury by improving glymphatic dysfunction.
Materials and Methods
Ischemic stroke was induced using the mice middle cerebral artery occlusion (MCAO) model. The C57/BL6 mice were randomly divided into three groups as follows: sham operation, Ischemia-reperfusion (I/R) 48 hours, and N-(1,3,4-thiadiazol-2-yl) pyridine-3-carboxamide dihydrochloride (TGN-020) + I/R 48 hours treatment. Neurological examination, TTC, fluorescence tracer, western blot, and immunofluorescence staining were performed in all mice in sequence. The glymphatic function in the cortex surrounding cerebral infarction was determined using tracer, glial fibrillary acid protein (GFAP), aquaporin-4 (AQP4) co-staining, and beta-amyloid precursor protein (APP) staining, differential genes were detected using RNA-seq. Iba-1, IL-1β, TNF-α, cleaved caspase 3, and tunel staining were used to verify inflammation and apoptosis after TGN-020 treatment.
Results
Compared with I/R group, the degree of neurological deficit was alleviated in TGN-020 group. TGN-020 alleviated glymphatic dysfunction by improving astrocyte proliferation and reducing tracer accumulation in the peri-infarct area. RNA-seq showed that the differentially expressed genes were mainly involved in the activation of astrocytes and microglia, and involved in the ERK pathway. RNA-seq was verified by western blot and immunofluorescence.
Conclusions
The inflammation of astrocytes and microglia after cerebral ischemia-reperfusion (I/R) is closely related to the glymphatic system. The improvement of glymphatic function may play a neuroprotective role after cerebral I/R by inhibiting inflammation through ERK pathway.
Target the concomitant risk factors for pulmonary hypertension in an HIV-positive man: a case report
Authors: Sun Cuiming , Wen Ying , Chen Yanli 
Published: April 2023

Abstract
Background

Pulmonary hypertension (PH) is a progressive disease characterized by elevated pulmonary arterial pressure causing right ventricular failure and death. HIV infection is one of the high-risk factors for the development of PH and HIV-related PH is associated with non-AIDS-related comorbidities. In this study we report a case of pulmonary hypertension with several concomitant risk factors, who experienced a complete clinical improvement after drug rehabilitation, application of anti-retroviral therapy (ART) and Sildenafil.

Case presentation

A 37-year-old HIV-positive man complained about worsening dyspnea was diagnosed with severe pulmonary hypertension. Pulmonary hypertension in this case was characterized by association with multi-factors including amphetamine inhalation, HIV infection, bacterial liver abscess with the history of splenectomy and past ventricular septal defect, which was different from previously reported cases with HIV-related pulmonary hypertension who were associated solely to HIV infection.

Conclusion

Pulmonary hypertension should be suspected among HIV-positive patients with unexplained dyspnea. Notably, investigating the co-existent risk factors and a multidisciplinary team are crucial for early diagnose and improved prognosis of HIV- related pulmonary hypertension.
Evaluation of Photobiomodulation Therapy (117 and 90 seconds) on Pain, Regeneration, and Epigenetic Factors (HDAC 2, DNMT3a) Expression Following Spinal Cord Injury in A Rat Model
Authors: MotamedNejad Ali , Behroozi Zahra , Kookli Keihan , Ghadaksaz Alireza , Fazeli Seyedalireza Moghaddas , Moshiri Ali , Ramezani Fatemeh , Janzadeh Atousa 
Published: April 2023

Abstract

Background Photobiomodulation therapy (PBM), due to its anti-inflammatory, analgesic effects, and most importantly as a non-invasive procedure, has currently gained a special setting in pain relief and the treatment of Spinal cord injuries (SCI). However, the mechanism of action of the PBM is not yet completely understood. Methods In this study, SCI is induced by an aneurysm clip. Adult male rats were divided into 4 groups: Control, SCI, SCI + PBMT 90 seconds, and SCI + PBMT 117 seconds. After 7 weeks, hyperalgesia, allodynia, and functional recovery were assessed. Fibroblasts were counted after H&E staining. The expression of HDAC2, DNMT3a, GAD65, and GFAP after 4 weeks of daily PBMT (90 and 117 s) was probed by western blotting. Results Both PBMTs (90 & 117 seconds) significantly improved the pain and ability to move and fibroblast invasion was reduced. SCI + PBMT 90s, increased GAD65, HDAC2, and DNMT3a expression. However,PBMT 117s decreased GFAP, HDAC2, and DNMT3a. Conclusion PBMT 90 and 117 s improved the pain, and functional recovery equally. Yet, the mechanism of action appears to change with different durations of radiation.
WITHDRAWN: Electrochemical advanced oxidation processes: an efficient degradation method for the complete removal of Acid Blue 40
Authors: Júnior José Rubens Moraes , Claro Elis Marina Turini , Mendes Carolina Rosai , Dilarri Guilherme , Bidoia Ederio Dino 
Published: April 2023

Abstract

Degradation of Acid Blue 40 (AB40) anthraquinone dye by electrochemical treatment was examined using a dimensionally stable anode (DSA) and stainless-steel cathodes as electrode materials, with NaCl as supporting electrolyte and current density of 50 and 100 mA cm-2. To confirm if the electrolytic process was efficient in removing initial color and organic matter of the AB40 solution, spectrophotometric, chemical oxygen demand (COD) and biochemical oxygen demand (BOD5) analysis were performed. COD removal kinects were studied to evaluate the velocity rate of the reaction. Also, chloroform analysis was realized using a GC-MS to verify if it was generated during the process. Bioassays with Artemia salina, Saccharomyces cerevisiae and Lactuca sativa were performed to verify if the process reduced the initial toxicity. The electrolytic treatment presented itself as a remarkable process degrading almost completely 96.96% of the color in 10 minutes of treatment, using of current density of 50 mA cm-2. The AB40 solution became more degradable presenting an increase in the biodegradability index. A chloroform formation was observed with current density of 50 mA cm-2, however, it presented concentrations below the EPA-USA regulations. Bioassays presented low toxicity for the treated solutions. The electrolytic treatment was shown to be highly effective for degradation of AB40 dye solution and DSA electrodes showed remarkable catalytic activity with applied current. It has environmental compatibility with low-cost and durable electrodes. In addition, it was observed high energy efficiency, no requirement for large quantities of chemicals and the process presented safety under soft conditions.
Mountaineering Team-Based Optimization Technique to Solve Economic Load Dispatch Problem
Authors: REDDY Y VENKATA KRISHNA , Ramanaiah M Laxmidevi , Sudhakar A 
Published: April 2023

Abstract

Economical load dispatch (ELD) and combined economic emission dispatch (CEED) problems are solved using optimization approaches. In order to handle ELD and CEED problems, a novel metaheuristic optimization technique based on human intelligence called the mountaineering team based optimization (MTBO) algorithm is projected in this paper. The MTBO method implemented based on the human cooperation and social behaviour taking into account the usual occurrences to reach a mountain top, this represents the finest overall solution. The projected MTBO method is utilised to address optimisation problems. This approach involves analysing the stages of regular and climbing movements, which are based on the leader's experience, the obstacles encountered during the ascent, and the risk of being trapped in local optimum performance. Additionally, the group's coordination and social support are considered to safeguard members from common catastrophes. To evaluate the efficiency of the suggested method, considered six cases for the ELD problem and four cases for a CEED problem. Along with the MTBO, other optimization techniques like flower pollination algorithm (FPA), ant lion optimization (ALO) and grey wolf optimization (GWO) methods are used to solve ELD and CEED problem. The MTBO method outperforms the competition in terms of robustness, ease of implementation, effective optimization performance for a optimal global solutions.
Correlation between automated volumetry of temporal lobes and electroencephalography in dogs with idiopathic epilepsy
Authors: Drobot Paulina Kinga , Wrzosek Marcin Adam , Banasik Aleksandra Ewa , Owsińska-Schmidt Karolina Barbara , Podgórski Przemysław 
Published: April 2023

Abstract
Background: Refractory epilepsy is a concern for many canines diagnosed with idiopathic epilepsy. In humans, refractory epilepsy is most often associated with temporal lobe epilepsy (TLE). In dogs, TLE pathology can go unnoticed on standard magnetic resonance imaging (MRI) examination. In recent years, many studies have described the occurrence of TLE in dogs and cats diagnosed through volumetric evaluation of the hippocampus. Nevertheless, this has been performed manually, which may reduce the diagnostic sensitivity of the method. Additionally, due to the challenges involved in the manual assessment in dogs, volumetric evaluation of the brain lobes has not yet been possible. In contrast, automated volumetry has long been used for the diagnosis of many neurological diseases in humans. The development of veterinary medicine and availability of brain atlases has now made it possible to introduce automated volumetry in to veterinary neurology as well. Thus, this study aimed to develop an automatic volumetry method, translate the outcomes into the assessment of temporal lobe volume in dogs with idiopathic epilepsy, and correlate the results with the electroencephalography (EEG) of epileptiform discharges (EDs).
Results: An automated volumetry method was developed in this study, which allowed the evaluation of temporal lobe volumes of 31 dogs diagnosed with idiopathic epilepsy. The asymmetric ratio (AR) was then estimated and the results were correlated with the EEG EDs. Notably, 12/31 dogs had an AR greater than 6%. Among them, reduction in temporal lobe volume correlated with the side of the EEG EDs in seven cases. However, statistical analysis revealed no correlation between temporal lobe volume changes and ED location. There was a statistically significant difference in the AR between the group with a larger right ventricle and the group with symmetrical ventricles.
Conclusions: Our results may influence the classification of idiopathic epilepsy in dogs. Additionally, the diagnosis of TLE in dogs based on MRI volumetry in correlation with EEG examination, especially for dogs with drug-resistant epilepsy, can significantly influence the development of new therapeutic options such as surgery.
Etherswap (A crypto wallet)
Authors: Kaushalya Kaushalya Thopte , Yukta Yukta Pedhavi , Deepak Deepak Gavit , Suyash Suyash Gaikwad , Rushikesh Rushikesh Kale , Rahul Rahul Nagpure 
Published: April 2023

Abstract
This project aims to produce a cryptocurrency blockchain application. An online application can be accessed via this Blockchain Application System. Everyone with a net connection is able to access it throughout the Internet. This programme will assist the user in sending and receiving Ethereum over the blockchain network. A blockchain is a distributed, trustworthy data repository. Public-key cryptography and the Nobel idea are combined to make it work. The legitimate owner of the resource being traded signs each transaction on the blockchain. New currencies (resources) are created and given to an owner. Simply embed the new owner's public key in the transaction and sign it with the owner's private key to get ready for subsequent transactions that deliver those coins to other people. In this manner, a verifiable chain of transactions is established, with each new transaction linking to the previous transaction with the previous owner and having a new owner.
Complex of antamanide with the nitrate anion
Authors: Vaňura Petr , Sýkora David , Uhlíková Tereza 
Published: April 2023

Abstract

Anionic complex of antamanide with the nitrate anion has been proven by electrospray ionization mass spectrometry (ESI-MS) method. Further, applying quantum chemical DFT calculations, the most probable structure of this complex was derived. The nitrate anion is embedded in the molecule of antamanide and its oxygens atoms are bonded by seven bonds to the hydrogen atoms of the ligand. Finally, the interaction energy, E(int), of the antamanide-NO3- complex was calculated as E(int) = -175.9 kJ/mol