bluuebunny/crossref_metadata_2025_split huggingface dataset:
Citrulline enteral administration markedly reduces immunosuppressive extrafollicular plasma cell differentiation in a preclinical model of sepsis
Authors: Gauthier Juliette , Grégoire Murielle , Reizine Florian , Lesouhaitier Mathieu , Desvois Yoni , Ghukasyan Gevorg , Moreau Caroline , Amé Patricia , Tarte Karin , Tadié Jean‐Marc , Delaloy Céline 
Published: December 2022

AbstractThe sustained immunosuppression associated with severe sepsis favors an increased susceptibility to secondary infections and remains incompletely understood. Plasmablast and plasma cell subsets, whose primary function is to secrete antibodies, have emerged as important suppressive populations that expand during sepsis. In particular, sepsis supports CD39hi plasmablast metabolic reprogramming associated with adenosine‐mediated suppressive activity. Arginine deficiency has been linked to an increased risk of secondary infections in sepsis. Overcoming arginine shortage by citrulline administration efficiently improves sepsis‐induced immunosuppression and secondary infections in the cecal ligation and puncture murine model. Here, we aimed to determine the impact of citrulline administration on B cell suppressive responses in sepsis. We demonstrate that restoring arginine bioavailability through citrulline administration markedly reduces the dominant extrafollicular B cell response, decreasing the immunosuppressive LAG3+ and CD39+ plasma cell populations, and restoring splenic follicles. At the molecular level, the IRF4/MYC‐mediated B cell reprogramming required for extrafollicular plasma cell differentiation is shunted in the splenic B cells of mice fed with citrulline. Our study reveals a prominent impact of nutrition on B cell responses and plasma cell differentiation and further supports the development of citrulline‐based clinical studies to prevent sepsis‐associated immune dysfunction.
Heterodinuclear M1M2 Complexes (M1=Ni, Pd, Pt; M2=Rh, Ir) Supported by a Tetradentate Phosphine Ligand and Their Application for Hydrosilylation
Authors: Nakajima Takayuki , Takubo Mizuki , Komura Yurika , Maeda Yuki , Sato Miwa , Zouda Maki , Tanase Tomoaki 
Published: December 2022

AbstractA new series of cationic heterodinuclear complexes, [M1M2Cl2(meso‐dpmppp)(RNC)2]PF6 (M1=Ni, M2=Rh, R=tBu (1 a); M1=Pd, M2=Rh, R=tBu (2 a), Xyl (2 b); M1=Pt, M2=Rh, R=tBu (3 a), Xyl (3 b); M1=Pd, M2=Ir, R=tBu (4 a)), supported by a tetradentate phosphine ligand, meso‐Ph2PCH2P(Ph)(CH2)3P(Ph)CH2PPh2 (meso‐dpmppp), were synthesized by stepwise reactions of meso‐dpmppp with NiCl2 ⋅ 6H2O or MCl2(cod) (M=Pd, Pt), forming mononuclear metalloligands of [M1Cl2(meso‐dpmppp)], and with [M2Cl(cod)]2 (M2=Rh, Ir) and RNC (R=tBu, Xyl) in the presence of [NH4][PF6]. The related neutral PdRh complex, [PdRhCl3(meso‐dpmppp)(XylNC)] (5), was also prepared. The structures of 1–5 were determined by X‐ray analyses to contain two square planar d8 metal centers with face‐to‐face arrangement, where meso‐dpmppp supports M1 and M2 metal ions in cis/trans‐P,P coordination mode, combining cis‐{M1P2Cl2} and trans‐{M2P2(CNR)2} units. Complexes 1–4 showed an intence characteristic absorption around 422–464 nm derived from RhI→RNC MLCT transition (HOMO→LUMO+1), which are influenced by changing M1 (NiII, PdII, PtII) metal ions since HOMO composed of dσ* orbitals appreciably destabilized by changing M1 from Ni to Pd, and Pt. The electronic structures of 1 a–4 a were investigated on the basis of DFT calculations and NBO analyses to show weak but noticeable d8–d8 metallophilic interaction as empirical dispersion energy of 0.9–1.5 kcal/mol without M1–M2 covalent bonding interaction. In addition, 1–5 were utilized as catalysts for hydrosilylation of styrene, and the NiRh complex 1 a was found to show higher activity and chemo‐ and regioselectivity compared with 2–5.
Synthesis of 4‐Alkenylated Pyrazolinones by 2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ)‐Mediated Oxidative Coupling Reaction
Authors: Tao Yuhui , Gu Huafang , Xia Hongshuang , Yang Hongjiao , Li Jinghua , Xu Xiaoliang , Cheng Dongping 
Published: December 2022

Abstract1,3‐Diarylpropenes firstly serve as efficient alkenylated reagents for the functionalization of pyrazolinones. In the presence of 2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ), it undergoes oxidative coupling and final dehydrogenation to give the highly substituted E,E‐α,β,γ,δ‐dienpyrazolinones in moderate to excellent yields.
Electrocatalytic Determination of the antibiotic Levofloxacin using modified carbon paste electrode with a poly‐murexide thin film voltammetrically
Authors: Khodari M. , Hassan Nahla Z. , Mohamed Adila E. , Rashed M. N. 
Published: December 2022

AbstractIn this work, a simple, cheap, sensitive, and selective modified carbon paste electrode is proposed for the electroanalytical determination of Levofloxacin (LEVO), the drug used to treat pneumonia caused by coronavirus. The electrochemical polymerization method was applied to create a thin poly‐murexide film (POMUR) on the bare carbon paste electrode (BCPE) surface to enhance its electrocatalytic activity. The peak current response of LEVO obtained by POMUR/CPE was increased by 14.2 μA compared to BCPE. Scanning electron microscopy (SEM) and cyclic voltammetry (CV) techniques were employed to characterize BCPE and POMUR/CPE. Under the optimal experimental circumstances, the prepared sensor was capable of determining LEVO with a low limit of detection (LOD) of 7.18 nM (S/N = 3) for a linear dynamic range of 25 – 1 × 103 nM utilizing differential pulse voltammetry (DPV). Moreover, the practical applicability of POMUR/CPE for determining LEVO in pharmaceutical formulations and biological samples (human serum) demonstrated high sensitivity and selectivity with a recovery of 95.08 – 100.5 %.
The contribution of grain sorting to the dynamics of the bedload active layer
Authors: Recking Alain , Vázquez Tarrío Daniel , Piton Guillaume 
Published: December 2022

AbstractDuring the last 20 years, flume and field experiments have shown that grain sorting contributes to bed‐level fluctuations and bedload pulses. In this work, we propose a new analysis of these experimental data. From the flume data, we derive a model for gravel‐bed rivers where both local (bedform‐scale) slope and bedload are known to fluctuate through space and time, in the so‐called ‘bedload active layer’. The model uses standard concepts and empirical tools with reach‐averaged data for the hydraulics and sediment transport. It considers a maximum slope for local armouring equal to the mean bed slope (reach scale) affected by a coefficient which expresses the difference in mobility of the coarse fraction considered alone or in a mixture. The minimum local slope for bed erosion is the mean bed slope corrected by a coefficient that depends on the armour ratio Ar (ratio of the surface to the subsurface grain diameter) and the reach‐averaged transport rate. The model is compared with a compilation of scour–fill depths measured in the field. Results suggests that the slope fluctuations in 1D flume experiments are consistent with in‐channel bed‐level fluctuations associated with scour–fill processes in the active layer. The model also suggests that although the length scale of the maximum scour depth δ is on the order of the bed surface D90, it is well explained by the product between the mean bed slope S and the active channel width W, with δ ≈ 1.4SW. For the pulse intensity, we provide a justification for the simplified squared slope equation for solid concentration C = Qs/Q ∝ S2 (with Qs the solid discharge, Q the water discharge and S the slope), which has often been used in place of standard bedload equations for modelling highly concentrated bedload transport events in mountain streams.
Enhanced Elman spike neural network for cluster head based energy aware routing in WSN
Authors: Meenakshi B. , Karunkuzhali D. 
Published: December 2022

AbstractAn enhanced Elman spike neural network (EESNN) optimized with hybrid wild horse optimization and chameleon swarm algorithm is proposed in this manuscript for multi‐objective cluster head selection and energy aware routing in wireless sensor network (CH‐EESNN‐Hyb‐WH‐CSOA‐WSN). Initially, EESNN is used to intelligent selection of cluster head. Then, the optimal cluster head utilized the selected data transferring process with the consideration of multi‐objective fitness function based EESNN. Here, some of the multi‐objective fitness function factors are considered, like energy, delay, throughput, distance between the nodes, traffic rate and cluster density. The hybrid wild horse optimization and chameleon swarm algorithm (Hyb‐WH‐CSOA) is taken into account for the optimal route path selection with minimal delay. The proposed CH‐EESNN‐Hyb‐WH‐CSOA‐WSN method is activated in network simulator 3 (NS‐3) tool. The performance of the proposed method is examined under certain performance metrics, like count of alive nodes, drop, network lifetime, delay, throughput, energy consumption, and packet delivery ratio. Finally, the proposed method attains 98.78%, 97.21%, 99.61% lower delay, 98.78%, 99.21%, 96.78% higher delivery ratio, and 99.57%, 98.67%, 98.88% lower packet drop compared with the existing methods, like optimal secure cluster head placement through source coding techniques in wireless sensor networks (CHP‐HMC‐WSN), optimal placement of single cluster head in wireless sensor networks via clustering (CHP‐K‐Means C‐PSO‐WSN) and hybrid firefly approach along particle swarm optimization for energy efficient optimum cluster head selection in wireless sensor networks (CHP‐HFAPSO‐WSN) respectively.
Temporary induction of hypoxic adaptations by preconditioning fails to enhance Schwann cell transplant survival after spinal cord injury
Authors: David Brian T. , Curtin Jessica J. , Brown Jennifer L. , Scorpio Kerri , Kandaswamy Veena , Coutts David J. C. , Vivinetto Ana , Bianchimano Paola , Karuppagounder Saravanan S. , Metcalfe Mariajose , Cave John W. , Hill Caitlin E. 
Published: December 2022

AbstractHypoxic preconditioning is protective in multiple models of injury and disease, but whether it is beneficial for cells transplanted into sites of spinal cord injury (SCI) is largely unexplored. In this study, we analyzed whether hypoxia‐related preconditioning protected Schwann cells (SCs) transplanted into the contused thoracic rat spinal cord. Hypoxic preconditioning was induced in SCs prior to transplantation by exposure to either low oxygen (1% O2) or pharmacological agents (deferoxamine or adaptaquin). All preconditioning approaches induced hypoxic adaptations, including increased expression of HIF‐1α and its target genes. These adaptations, however, were transient and resolved within 24 h of transplantation. Pharmacological preconditioning attenuated spinal cord oxidative stress and enhanced transplant vascularization, but it did not improve either transplanted cell survival or recovery of sensory or motor function. Together, these experiments show that hypoxia‐related preconditioning is ineffective at augmenting either cell survival or the functional outcomes of SC‐SCI transplants. They also reveal that the benefits of hypoxia‐related adaptations induced by preconditioning for cell transplant therapies are not universal.
Value of routine follow‐up in oropharyngeal squamous cell cancer patients treated with curative intent
Authors: Brands Maria T. , Swinkels Iris J. , Aarts Anne M. W. M. , Verbeek André L. M. , Merkx Matthias A. W. , Marres Henri A. M. , Kaanders Johannes H. A. M. , Melchers Willem J. G. , van Engen‐van Grunsven Ilse , Takes Robert P. , Geurts Sandra M. E. 
Published: December 2022

AbstractBackgroundThe major goal of routine follow‐up in oropharyngeal squamous cell carcinoma (OPSCC) patients is the asymptomatic detection of new disease in order to improve survival. This study evaluated the effect of routine follow‐up on overall survival (OS).MethodsA retrospective cohort of 307 consecutive OPSCC patients treated with curative intent between 2006 and 2012 was analyzed. The effectiveness of routine follow‐up was studied by comparing treatment‐intent and OS in patients with asymptomatically versus symptomatically detected new disease.ResultsThree‐ and five‐year risks of new disease were 29% (95% CI: 24–34) and 33% (95% CI: 27–39). Of the 81 patients with locoregional recurrence or second primary head and neck cancer, 8 (10%) were detected asymptomatically with no difference in OS with those detected with symptoms.ConclusionsAsymptomatic detection of new disease during routine visits was not associated with improved OS. The focus of follow‐up should be on providing psychosocial care and rehabilitation.
COVID‐19 vaccination coverage and vaccine hesitancy among Australians with disability and long‐term health conditions
Authors: Aitken Zoe , Emerson Eric , Kavanagh Anne Marie 
Published: December 2022

AbstractIssue AddressedCOVID‐19 vaccination is the cornerstone of managing Australia's COVID‐19 pandemic and the success of the vaccination program depends on high vaccination coverage. This paper examined differences in COVID‐19 vaccination coverage and vaccine hesitancy for people with disability, long‐term health conditions, and carers – subgroups that were prioritised in Australia's vaccination program.MethodsUsing data from 2400 Australians who participated in two waves of the Taking the Pulse of the Nation survey in April and May 2021, we described vaccination coverage and hesitancy among people with disability, severe mental health conditions, severe long‐term health conditions, frequent need for assistance with everyday activities, and carers.ResultsVaccination coverage was estimated to be 8.2% in the population overall and was similar for people with disability, those with frequent need for assistance, and carers. It was higher for people with severe long‐term health conditions (13.4%) and lower for people with severe mental health conditions (4.3%). Vaccine hesitancy was high overall (35.6%) and was similarly high across the priority groups, with only small differences for people with disability, severe long‐term health conditions and frequent need for assistance.ConclusionsThis study highlights a lack of difference in vaccination coverage for people with disability, long‐term health conditions, and carers compared to the general population.So what?Sub‐optimal vaccination coverage for people in the priority groups leaves many people at significant risk of serious disease or death if exposed to COVID‐19, particularly in light of easing of disease‐control restrictions across Australia and the emergence of new variants.
High performance work systems and employee mental health: The roles of psychological empowerment, work role overload, and organizational identification
Authors: Kim Kyoung Yong , Messersmith Jake G. , Pieper Jenna R. , Baik Kibok , Fu Sherry (Qiang) 
Published: December 2022

AbstractEmployee mental health is a central issue in today's global workplace. This paper analyzes the effect of high performance work systems (HPWSs) on employee mental health. We integrate HPWS concepts with job demands‐resources (JD‐R) theory to examine competing theoretical perspectives—a positive HPWS influence and a negative HPWS influence on employee mental health. We examine employees' perceptions of psychological empowerment as an indicator of the motivational pathway of the JD‐R and work‐role overload as an indicator of the strain pathway to explain the differential effect of HPWSs on mental health. We also incorporate organizational identification theory to demonstrate how one's identification with the organization can either accentuate or attenuate feelings of both psychological empowerment and work‐role overload. Findings from a study of 999 employees in 174 South Korean organizations indicate that HPWSs are positively associated with employee mental health via employee perceptions of empowerment and that HPWSs are negatively associated with employee mental health through perceptions of work‐role overload. Furthermore, the study finds that organizational identification attenuates the relationship between HPWS and both empowerment and overload. Practice‐level post hoc analyses also reveal that the job design characteristics, pay level, and participative decision‐making are linked to empowerment. In addition, participative decision‐making is most strongly associated with work overload.
Associative factors for atopic dermatitis and other atopic diseases in middle‐aged adults: A population‐based birth cohort study among 5373 subjects
Authors: Haarala Anna K. , Sinikumpu Suvi‐Päivikki , Jokelainen Jari , Pekkanen Juha , Huilaja Laura 
Published: December 2022

AbstractBackground and aimsThe study aimed to examine parental, longitudinal and current associative factors for atopic dermatitis (AD) and to compare those to other atopic diseases in 46‐year‐old adults.MethodsQuestionnaire data from the Northern Finland Birth Cohort 1966 study were used. To analyze allergic sensitization, skin prick tests (n = 5373) were performed for birch, timothy, cat, and house dust mite at age 46.ResultsMaternal (odds ratio [OR] 1.81; 95% confidence interval [CI] 1.25–2.59) and paternal allergy (OR 2.54; CI 1.76–3.64), sensitization to any of the four tested aeroallergens (OR 1.56; CI 1.04–2.30) as well as polysensitization (OR 3.04; CI 2.10–4.37) were associated with current AD. Living on a farm in infancy was negatively associated with allergic rhinitis, allergic conjunctivitis, and atopic multimorbidity. Current AD (OR 2.65; CI 1.44–4.60) and all atopic diseases associated with indoor air related symptoms. Current AD associated with other atopic diseases, most strongly with allergic rhinitis (OR 4.92; CI 3.92–6.22).ConclusionCurrent AD in a 46‐year‐old general population occurred frequently with allergic rhinitis, allergic conjunctivitis, and asthma in the Northern Finland Birth Cohort study 1966. Parental allergy and sensitization to common aeroallergens were found as shared associative factors for AD, allergic rhinitis, allergic conjunctivitis, and asthma. AD and other atopic diseases associated with symptoms related to poor indoor air quality. In daily practice, it is important to take these comorbidities into consideration when treating patients with AD.
The myth of normative development
Authors: Forbes Samuel H. , Aneja Prerna , Guest Olivia 
Published: December 2022

AbstractOver the past decade, the field of psychology has come under increasing fire for the replicability of purported findings, for the transparency of the methods used, and for the generalisability of the claims. In general, these criticisms have focused on the methodological and statistical aspects of published work. Herein, we highlight the importance of diversity of both our participant samples in empirical studies and of our researchers within developmental psychology as a barrier to generalisability. Far beyond being a purely methodological question, for example, of heterogenous sampling, ignoring the importance of context and environment in development implies risking failing to comprehend pivotal facets of development. Importantly, we discuss the harms done to our science's theoretical contributions as a direct result of defining and maintaining misplaced “norms” or “normative” developmental scenarios. Finally, we outline how even small steps by individuals can be impactful, such as ceasing to request unsubstantiated comparisons to the Western “norm” in peer review.Highlights
Developmental Psychology seeks to understand how humans develop.
To do this, we also need to understand the dynamic cultural context of participants and of the field.
A failure to do this sets up implied norms, which is harmful to the field and to our understanding of human development.
We examine these norms and make recommendations to avoid this phenomenon.
The impact of the “Attachment and Biobehavioural Catch‐Up” program on attachment related parent behavior—A systematic review
Authors: O'Byrne Emma , McCusker Chris , McSweeney Shane 
Published: December 2022

Abstract“Attachment and Biobehavioural Catch‐Up” (ABC) is a 10 session home visiting program, grounded in attachment theory. It aims to improve child emotion regulation, attachment and behavioral outcomes through changing caregivers’ attachment related behaviors. There is increasing evidence with respect to the effectiveness of ABC in producing positive child outcomes, but the intervention's direct effect on parent outcomes remains unclear. This review examined the association of ABC with attachment related parent outcomes. The PubMed, EMBASE, PyschINFO and SCOPUS databases were searched for relevant studies in August 2021, and again in April 2022. The eligibility criteria for included studies were (1) infants aged 0–27 months at time of the ABC intervention, (2) “at risk” parents, (3) controlled trials published in peer‐reviewed journals and (4) utilized a measure of attachment related parent outcomes. Eleven eligible studies were included. The findings showed ABC had a significant small to medium effect on a variety of attachment related parent outcomes among parents presenting with multiple psychosocial risk factors. “Sensitivity” was measured most frequently, with small to medium main effect sizes recorded at follow‐up, compared to controls. Implications for the clinical effectiveness of the ABC program in community settings are discussed. Future research should clarify who ABC is most effective for and how it compares to similar interventions.
Grain yield prediction model based on the analysis of climate and irrigated area conditions in the wheat grain‐filling period
Authors: Gong Qizhou , Huang Hongliang , Zhang Bingjiang 
Published: December 2022

AbstractThe food problem is a major issue of common concern around the world, and the forecasting of wheat output can help to promote the solution of this problem. This paper analyses the relationship between wheat yield and weather, precipitation and irrigated area; proposes a Bayesian optimized machine model of the XGBoost regression algorithm; and applies it to forecast wheat yield in Uttar Pradesh, India. Second, the stability and robustness of the XGBoost model using the top five parameter combinations of the optimization score were evaluated by cross‐validation, and the best model was used to predict wheat yield in Uttar Pradesh, India. Finally, the model is compared with other prediction models, and the tenfold cross‐validation experimental results show the effectiveness of the model. Ultimately, by learning from the available data and using the 2022 wheat irrigation data to forecast wheat yield per acre, we obtain a wheat production estimate of 17 930 817 t in Uttar Pradesh in 2022, which is a decreasing trend from previous years' wheat output. The impact of extreme heat on total production is somewhat contained by the year‐on‐year increase in the irrigated area in Uttar Pradesh.