bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness in storing and reducing floods of the red river upstream reservoirs under the incident of Lienmac dyke
Authors: Nguyen Dang Giap , Dao Cong-Binh , Mai Viet-Chinh 
Published: August 2023

Abstract
The Red river and Thai Binh river’s dyke system includes 56 dikes classified from grade III to special grade with a total length of 2.207,75km which 37.709km of special grade, 553.70km of grade I, 502,43km of grade II and grade III. At the present, on the Red River and Thai Binh River systems, there are 230 existing weak locations, which have not been completely reinforced yet. It might cause unsafety situations of large flood flush and high water levels of rivers for a long time. Therefore, studying the solutions to support the response under unsafety situations of the dike system is a significant meaning topic. The present paper aims to evaluate the effectiveness of solutions using reservoirs at the Red river upstream in order to store and reduce floods in downstream. This also supports the effort to respond the urgent situations upstream such as huge floods, dyke failures in downstream and dyke failure at Lien Mac. In the scope of this paper, one and two-dimensional hydraulic simulation method was utilized, which describes the scenarios to regulate the upstream reservoir of the Red River and hydraulic calculation of the downstream river network. Then, the effectiveness of flood reduction in each scenario can be estimated. Simulation results show that depending on the calculation scenarios, the capacity of reservoirs can be 5.553 million m3 to cut and reduce flood for downstream. The flooded area might be decreased by 47.528 ha in case using a part of the capacity of the construction. The time when the reservoirs completely close the floodgates and do not discharge the flood into downstream is from 27 to 30 hours, this is an important time for the Lien Mac dike to be completely sealed within 24 hours. The time when the reservoirs completely close the floodgates and do not discharge the flood into downstream is from 27 to 30 hours, this is an important time for the Lien Mac dike to be completely closed within 24 hours.
A study on using nano calcite as the accelerated agent in microbially induced calcium carbonate precipitation for soil-sand bio-cementation
Authors: Huynh Nguyen Ngoc Tri , Huyen Nguyen Pham Huong , Duc Nguyen Anh , Thien Nguyen Thanh , Truong Ho Van , Son Nguyen Khanh 
Published: August 2023

Abstract
Bio-cementation through bacterial mineralization can be considered an “eco-friendly” solution for soft or loose sandy soils, particularly in ground slopes and high rainfall zones, to achieve sustainable development goals. Using urelytical bacteria with the ability to decompose urea for calcium carbonate precipitation can be selected as the primary agent for the bio-cementation process. This study clarifies the effects of adding nano calcite as nucleation sites for enhancing the bio-cementation with Vietnam-isolated bacteria. Both microstructure of the precipitation and MICP capacity were studied. Microscopic, SEM/EDS, and X-ray diffraction data were used to characterize and identify the mineral compositions. Also, a simulated rainfall model and wind flow were set up to evaluate the erosion resistance of sand samples.
Finite element analysis of compaction load to investigate the stress-deformation behavior of soil geosynthetic composite mass: A case study
Authors: Phan Truc , Gui Meen-Wah , Pham Thang 
Published: August 2023

Abstract
When building Soil Geosynthetic Composite (SGC) walls, fill compaction is normally carried out by operating a compactor in a general direction parallel to the wall face. In other words, a moving point or area load is often used to apply a compaction load on a newly installed soil lift. Pham (2009) and Wu and Pham (2010) demonstrated that the compaction-induced stress (CIS) caused by multiple passes of a compactor moving toward or away from a section can be calculated by taking into account the compaction load applied directly above the section under consideration using a simplified stress path proposed by Duncan and Seed (1986). Additionally, by simulating the compaction, the CIS due to fill compaction may be correctly assessed. The CIS resulting from fill compaction can also be accurately assessed by simulating the compaction load, such as by applying a distribution load on top of each backfill layer or a distribution load at the top and bottom of each soil layer, or by applying various widths of strip load to the top of each backfill layer. The objective of this study was to validate the numerical simulation of the compaction load to stress deformation behavior of SGC mass under operating stress conditions. In order to conduct the numerical analysis, data from both a full-scale instrumented SGC mass based on large-scale soil geosynthetic composite (SGC) experiments and a 6 m-high SGC (Pham, 2009) were employed. This study will examine a few SGC behavior parameters, including reinforcement strains, lateral displacements, and reinforcement strains. The objective of the FE modeling is to demonstrate the effect, emphasize the significance of the compaction conditions to the stress-deformation behavior of SGC mass, and validate the findings from the field-scale experiments and proposed model by Pham (2009) and Wu and Pham (2010).
Simulation of shallow landslides induced by typhoon in July 2018 in Gogoshima, Ehime Prefecture, Japan based on a simple model
Authors: Nguyen T V , Ozaki T , Wakai A , Kimura T , Sato G , Kitamura N 
Published: August 2023

Abstract
Every year, many typhoons make landfall in Japan causing disasters on mountain slopes across the country. Rainfall induced landslides in Japan mostly occur at shallow depths. Developing simple models of rainfall-induced landslides provides a practical alternative to finite element methods in large-scale landslide modelling and prediction. Therefore, authors previously developed a simple method to calculate the advance of the wetting front into fine sand slopes subjected rainfall. However, during intense rainfall, the excess rainfall that cannot be absorbed into the soil will generate runoff on the slope surface, which has not been included in the previous model. Thus, this study integrated the model with a surface water modeling module to simulate the disasters more comprehensively. The surface water is controlled by 2D shallow water equations and the digital elevation model depression removal process. The combined model is able to provide the maps of the wetting front, surface water depth, and factor of safety of slope during rainstorms. The newly integrated model was used to simulate rainfall-induced disasters in the Gogoshima Island during the July 2018 typhoon. The simulation results disclosed that both moving of the wetting front and surface water flows contributed to shallow landslides along catchments in this island.
An energy-sensitive interfacial-superconductor photodetector
Authors: Wang Xiaohan , Chen Qi , Liu Ruxin , Wang Hao , Zhang Xu , Ma Liang , Guan Yanqiu , Zhang Biao , Li Haochen , Guo Shuya , Yang Zhuolin , Yu Shun-Li , Wang Xuefeng , Tu Xuecou , Jia Xiaoqing , Zhao Qingyuan , Chen Jian , Kang Lin , Zhang Labao , Wu Peiheng 
Published: August 2023

Abstract
The investigation of photon response in the superconducting state of interfacial superconductors holds both fundamental and practical significance, yet it remains largely unexplored. Here, we report an energy-sensitive photodetector utilizing a microstrip patterned on an interfacial superconductor (LaAlO3/KTaO3), achieving photon response spanning from visible to near-infrared wavelengths. Remarkably, the photon response pulse amplitude at the same wavelength is linearly related to the incident light power, showing a unique detection capability that is different from the conventional superconducting single-photon detectors. Our results suggest that the energy-sensitive characteristic arises from the Kondo effect observed in the two-dimensional electron gases of the interfacial superconductor, wherein incident photons alter the normal resistance. This study broadens the potential applications of interface superconductors and presents a versatile approach for the advancement of energy-sensitive photodetection technologies.
Deep-learning-based image segmentation for image-based computational hemodynamic analysis of abdominal aortic aneurysms: a comparison study
Authors: Lyu Zonghan , King Kristin , Rezaeitaleshmahalleh Mostafa , Pienta Drew , Mu Nan , Zhao Chen , Zhou Weihua , Jiang Jingfeng 
Published: August 2023

Abstract
Computational hemodynamics is increasingly being used to quantify hemodynamic characteristics in and around abdominal aortic aneurysms (AAA) in a patient-specific fashion. However, the time-consuming manual annotation hinders the clinical translation of computational hemodynamic analysis. Thus, we investigate the feasibility of using deep-learning-based image segmentation methods to reduce the time required for manual segmentation. Two of the latest deep-learning-based image segmentation methods, ARU-Net and CACU-Net, were used to test the feasibility of automated computer model creation for computational hemodynamic analysis. Morphological features and hemodynamic metrics of 30 computed tomography angiography (CTA) scans were compared between pre-dictions and manual models. The DICE score for both networks was 0.916, and the correlation value was above 0.95, indicating their ability to generate models comparable to human segmentation. The Bland-Altman analysis shows a good agreement between deep learning and manual segmentation results. Compared with manual (computational hemodynamics) model recreation, the time for automated computer model generation was significantly reduced (from ∼2 h to ∼10 min). Automated image segmentation can significantly reduce time expenses on the recreation of patient-specific AAA models. Moreover, our study showed that both CACU-Net and ARU-Net could accomplish AAA segmentation, and CACU-Net outperformed ARU-Net in terms of accuracy and time-saving.
Transboundary effects from idealized regional geoengineering
Authors: MacMartin Douglas G , Kravitz Ben , Goddard Paul B 
Published: August 2023

Abstract
Regional geoengineering, by reflecting sunlight over a very limited spatial domain, might be considered as a means to target specific regional impacts of climate change. One of the obvious concerns raised by such approaches is the extent to which the resulting effects would be detectable well beyond the targeted region (e.g. in neighbouring countries). A few studies have explored this question for targeted regions that are still comparatively large. We consider idealized simulations with increased ocean albedo over relatively small domains; the Gulf of Mexico (0.23% of Earth's surface) and over the Australian Great Barrier Reef (0.07%), both with negligible global radiative forcing. Applied over these very small domains, the only statistically significant non-local changes we find are some limited reduction on summer precipitation in Florida in the Gulf of Mexico case (adjacent to the targeted region). The lack of transboundary effects suggests that governance needs for such targeted interventions are quite distinct from those for more global sunlight reflection.
VAPEX: an interactive web server for the deep exploration of natural virus and phage genomes
Authors: Hepp Benjamin , Lorieux Florence , Degaugue Augustin , Oberto Jacques 
Published: August 2023

Abstract

Motivation
Studying the genetic makeup of viruses and phages through genome analysis is crucial for comprehending their function in causing diseases, progressing medicine, tracing their evolutionary history, monitoring the environment, and creating innovative biotechnologies. However, accessing the necessary data can be challenging due to a lack of dedicated comparative genomic tools and viral and phage databases, which are often outdated. Moreover, many wet bench experimentalists may not have the computational proficiency required to manipulate large amounts of genomic data.

Results
We have developed VAPEX (Virus And Phage EXplorer), a web server which is supported by a database and features a user-friendly web interface. This tool enables users to easily perform various genomic analysis queries on all natural viruses and phages that have been fully sequenced and are listed in the NCBI compendium. VAPEX therefore excels in producing visual depictions of fully resolved synteny maps, which is one of its key strengths. VAPEX has the ability to exhibit a vast array of orthologous gene classes simultaneously through the use of symbolic representation. Additionally, VAPEX can fully analyze user-submitted viral and phage genomes, including those that have not yet been annotated.

Availability and implementation
VAPEX can be accessed from all current web browsers such as Chrome, Firefox, Edge, Safari, and Opera. VAPEX is freely accessible at https://archaea.i2bc.paris-saclay.fr/vapex/.
O02 A case for diagnosis: ectodermal dysplasia and severe myelodysplasia
Authors: O’Connor Cathal , Bourke John 
Published: August 2023

Abstract
A 13-year-old girl was referred to us by our paediatric colleagues due to vulval dermatitis. She had a history of congenital hypotrichosis, microcephaly, abnormal dentition, dyshidrosis manifest as recurrent febrile seizures in infancy, recurrent infections, neutropaenia and macrocytosis. Her father and younger brother have a similarly striking phenotype, with complete absence of scalp and body hair, abnormal teeth, abnormal sweating, but normal nails. In addition, the father has required a stem cell transplant for myelodysplastic syndrome. None of the family have keratoderma, cleft palate, ectrodactyly or cardiomyopathy. DNA from our index patient was sent to Cardiff for the ectodermal dysplasia (ED) plus 70 gene panel for next-generation sequencing, but no mutation was found. Our paediatric haematology colleagues sequentially arranged dyskeratosis congenita panel, myeloid panel, and whole-exome sequencing for the younger brother, which did not identify a causative mutation. Unusually, all three were found to have mosaic trisomy 18. The transmission of trisomy 18 from parent to child as a mosaic trait in both generations is extremely unusual, and mosaic trisomy 18 has not been previously reported to cause ED. We would appreciate any input on a genetic diagnosis for this family with a distinctive phenotype consistent with hypohidrotic ED associated with myelodysplasia, with extensive genetic testing revealing a potentially spurious or coincidental mosaic trisomy 18 in all three affected family members.
O04 Segmental congenital haemangioma: a novel subtype of a rare vascular tumour
Authors: Oyedepo Jadesola , Glover Mary , O’Neill Claire , Polubothu Satyamaanasa , Solman Lea 
Published: August 2023

Abstract
Congenital haemangiomas (CH) are rare vascular tumours present at birth. These high-flow vascular lesions can lead to significant morbidity secondary to high-output cardiac failure (HOCF) and Kasabach–Merritt phenomenon (KMP). They are classically round/oval lesions and present anywhere on the body. The majority involute spontaneously in the first 2 years of life. We describe three patients who presented with an unusual segmental pattern CH of the head/scalp: the first with a segmental CH of the left forehead, extending over the left eye with associated ipsilateral heterochromia and anisocoria; the second with a segmental ulcerated CH of the right scalp – catastrophic haemorrhage from the CH sadly resulted in death at age 6 weeks; the third with a left forehead segmental CH. None of the CH in this series developed HOCF or KMP. All lesions were consistent with CH on sonography and histology where available. Patients 1 and 3 exhibited spontaneous involution in the first 2 years of life. Segmental CH have been reported once before in a series of three patients, although involving the arm/trunk rather than the head. Two of the three patients developed KMP/HOCF. The genetic basis in this cohort was identical to that of classic nonsegmental CH, activating somatic mutations in GNAQ/11. The striking segmental pattern in our cohort is likely attributable to the timing of the somatic hit during development. Identification of this pattern in CH gives important insights into vascular tumorigenesis. Further cohort studies are needed to determine if this group has differing clinical outcomes from classical CH.
P03 Utility of the infantile haemangioma referral score in optimizing referrals to a specialist centre
Authors: Harrington Robert , Leahy Marion , Byrne Berbie , Murphy Annette 
Published: August 2023

Abstract
The Infantile Haemangioma Referral Score (IHReS) is a validated, decision-making tool designed to aid physicians in appropriate and timely referral of patients with infantile haemangiomas (IH) to specialist centres. Previous studies have assessed its usefulness in identifying patients who require referral; however, none have analysed its utility in identifying those who do not. We sought to assess the use of the IHReS score by GPs and paediatricians and to correlate the patients’ score with outcomes through retrospective, cross-sectional analysis of all new IH referrals to a dedicated IH clinic over 6 months. The IHReS was retrospectively applied using information from referral letters and dermatology clinic letters. Data on demographics, wait time and outcomes were analysed. Forty-four patients were identified (females, n = 23; males, n = 21). The mean age at referral was 30 (SD 48) weeks. Only three (7%) referrals had recorded the patient's IHReS. Overall, 17 (39%) patients did not satisfy criteria for referral when the IHReS was applied retrospectively. Of these, 10 (59%) were discharged on the first visit, 6 (35%) were offered follow-up and one did not attend. No patients in this group received propranolol. Of the 27 (61%) patients who met the IHReS criteria 12 (44%) required propranolol, 11 (41%) were monitored for potential treatment, and 4 (15%) were discharged. The IHReS is a useful tool for identifying patients with IH who do not require referral to a specialist centre. It is underutilized by GPs and paediatricians and its use could reduce the number of inappropriate referrals to dermatology.
P05 Biologics combined with conventional systemic agents for the treatment of children with severe psoriasis: real-life data from the BiPe cohorts
Authors: Mahé Emmanuel , Hadj-Rabia Smaïl , Mazereeuw-Hautier Juliette , Mallet Stéphanie , Phan Alice , Severino-Freire Maëlle , Boralevi Franck , Aubert Hélène , Barthelemy Hugue , Girard Céline , Martin Ludovic , Barbarot Sébastien , di Lernia Vito 
Published: August 2023

Abstract
Combined therapies, defined as treatment modalities involving combinations of two or more drugs, are used with three main aims: to increase the efficacy of each drug; to reduce the toxicity of each drug; and, in some cases, to reduce costs by reducing the required dosages of each treatment. We explored the use of combinations of conventional systemic therapies and biologics in children with psoriasis in daily practice from the 170 children in the Franco–Italian BiPe cohorts to evaluate the use, efficacy and safety of combined conventional systemic–biologic therapies. In total, 33 children (19.4%) from 13 dermatology centres received 48 combined conventional systemic–biologic therapies (cumulative duration 43.6 years), including three triple combination therapies (acitretin–methotrexate, with a TNF-α inhibitor). Fourteen different combinations were used, most frequently etanercept–acitretin (n = 10), adalimumab–acitretin (n = 7), adalimumab–methotrexate (n = 5) and ustekinumab–methotrexate (n = 5). The combined therapies were started at biologic initiation in 41 cases (85.4%), and after a period of biologic monotherapy in the remaining seven cases. Mean PGA and PASI scores decreased between baseline and M3 with all the combinations used. Four serious adverse events were reported, all with favourable outcomes. Combined therapies have been used frequently in the treatment of childhood psoriasis, in a range of clinical situations and in variable drug combinations, without significant toxicity. Although the use of these combined therapies needs to be clarified in future management guidelines, these combined therapies should be considered for the treatment of children with severe psoriasis, psoriatic arthritis and recalcitrant ­disease.
P08 Linear IgA bullous dermatosis: treatment challenge
Authors: Bulic Suzana Ozanic , Gagro Alenka , Pustisek Nives , Ulamec Monika 
Published: August 2023

Abstract
Linear IgA bullous dermatosis (LABD) is a rare idiopathic or drug-induced autoimmune blistering disease characterized by widespread annular blisters caused by IgA autoantibodies directed against different antigens of the basement membrane zone (BMZ) of the skin and mucosae. Linear deposits of IgA at the dermoepidermal junction are a dominant diagnostic feature. Dapsone is the most commonly used systemic treatment with complete remission achieved in most patients. A 15-month-old boy presented with widespread annular blisters, erosions and haemorrhagic crusts on the face, scalp, torso, extremities and genital skin. An episode of acute bronchitis preceded the skin lesions. The patient was otherwise healthy. A skin biopsy of a lesion showed subepidermal blistering with neutrophils and eosinophils in the superficial dermis. Direct immunofluorescence revealed linear IgA and discrete linear IgG deposits along the BMZ. Treatment with oral prednisone 1–2 mg kg–1 daily and dapsone 1–2 mg kg–1 daily resulted in modest control of LABD and prompted introducing concomitant medications in the following sequence, IVIG, methotrexate 10 mg weekly for 6 months, and ciclosporin 5 mg kg–1 daily over 4 months, all with moderate disease control. Prednisone was stopped after 2 years and the LABD cleared with dapsone 2 mg kg–1 daily. The attempt of tapering the dapsone resulted in a flare. The treatment of LABD is based on case reports and varies with the degree of involvement and identification of inciting factors. The severe, treatment-resistant LABD in our patient, managed by the multidisciplinary team and shared care with the parents, resulted in a good and safe treatment outcome.
P10 Think zinc: nutritional deficiency in a breastfed infant associated with antenatal proton-pump inhibitor exposure
Authors: Porter Emma , Molloy Oonagh , Murphy Michelle , O’Connor Cathal 
Published: August 2023

Abstract
A 5-month-old infant presented with a 3-month history of a dramatic periorofacial and acral dermatitis associated with recurrent infections, increasing lethargy and poor feeding. He was born at full term, breastfed exclusively, and had no family history of skin disease. Serum alkaline phosphatase was 41 (range 82–383) and zinc levels were undetectably low (&lt; 3 mg mol–1; normal 10–25). Maternal breastmilk zinc levels were low (3.15, control mean 12.7), and maternal serum zinc was normal. A rapid improvement was noted within days of zinc sulfate supplementation. Zinc supplementation was stopped after 3 months, with normal follow-up zinc levels. The mother had taken omeprazole from 30 weeks’ gestation to birth. In her previous pregnancy there was no proton-pump inhibitor (PPI) ingestion, and no manifestation of zinc deficiency in the older sibling, who had also been breastfed exclusively. Maternal genetic testing for defects in SLC30A2, a zinc transporter in mammary tissue, was negative. Acrodermatitis enteropathica involves recessive mutations in the SLC39A4 gene, and secondary transient infantile zinc deficiency can be due to prematurity, low zinc intake, or malabsorptive processes such as cystic fibrosis. It is rare in breastfed infants due to enhanced bioavailability of zinc. PPIs can decrease serum zinc due to intestinal chelation, although little is known regarding their effect on transplacental or transmammary zinc transmission. To our knowledge this is the first report of zinc deficiency in a breastfed infant associated with maternal PPI use, potentially due to diminished transmammary and/or transplacental zinc transmission.