bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum growth differentiation factor 15 levels as a marker for liver cirrhosis and hepatocellular carcinoma on top of liver cirrhosis
Authors: Anis Zainab M.A. , Ahmed Amira Y. , Soliman Hanan H. , Nagy Hala M. 
Published: May 2023

BackgroundCirrhosis is the 14th leading cause of mortality globally. Additionally, it is subclassified by clinical stage. Hepatocellular carcinoma (HCC) was reported to account for ~4.7% of patients with chronic liver disease in Egypt. Early detection and treatment are highly beneficial. Growth differentiation factor 15 (GDF-15) proteins are implicated in the infection, fibrosis, and apoptotic processes of the liver. GDF-15 mRNA is mostly found in the heart, kidney, and lungs, as well as in the liver. The adult liver expresses the greatest amounts of GDF-15 following surgical and pharmacological therapies that produce acute liver damage.AimThis study’s objective was to assess serum GDF-15 levels in individuals with cirrhosis of the liver and HCC on top of cirrhosis of the liver.Patients and methodsWe have recruited 90 people in three groups: group 1 comprised 35 patients with HCC, group 2 comprised 35 individuals having cirrhosis of the liver, and group 3 comprised 20 nonhepatic individuals who acted as controls.ResultsIn the HCC group, alpha-fetoprotein (AFP) was significantly higher than in the cirrhosis group, and the cirrhosis group has significantly higher AFP than in the control group. In comparison with the cirrhosis group, and in comparison with the control group, the HCC group had a significant increase in GDF-15 level.ConclusionsGDF-15 levels were substantially greater in individuals with HCC compared with patients with cirrhosis and healthy controls. It is more sensitive, specific, and accurate than AFP. Thus, we may regard GDF-15 as a new marker for the diagnosis of HCC.
Optical coherence tomography angiography of macular area in diabetic patients and healthy subjects
Authors: Ebidw Eman E.F. , El-Emam Sharif Y. , El-Touky Hesham M. , El-Koumy Hamdy A. El-Azim 
Published: May 2023

Background
Diabetic retinopathy is a complication of the microvessels related to diabetes that most commonly leads to blindness. Optical coherence tomography angiography (OCTA) is an innovative noninvasive procedure that allows depth-resolved imaging of the microvessels of the retina and choroid.

Aim
The aim of this work was to study OCTA of macular area in diabetic patients having no diabetic macular edema and in healthy persons.

Patients and methods
This cross-sectional, prospective research included 55 participants who were divided into two groups: group I included 30 eyes of 30 cases with type 2 diabetes mellitus [having no diabetic macular edema on fluorescein angiography (FA), clinical assessment, and optical coherence tomography (OCT) macular B-scan], and group II included 25 eyes of 25 healthy persons not having any ocular or systemic diseases. Both groups underwent FA, OCTA, and OCT. Two metrics from OCTA images were quantified: foveal avascular zone area and vessel area density at two levels, that is, superficial capillary plexus and deep capillary plexus. Moreover, diabetic changes such as microaneurysms, capillary nonperfusion, and vessel tortuosity were estimated in the two groups.

Results
Between cases and controls, a statistically significant variance in vessel area density values and foveal avascular zone area was observed in superficial capillary plexus and deep capillary plexus utilizing OCTA. No significant differences were detected between diabetic cases and normal participants regarding central foveal thickness.

Conclusions
OCTA was capable of detecting microvascular alterations in diabetic eyes before visualization through clinical evaluation or FA. OCTA may be able to rapidly and noninvasively test for diabetic maculopathy.
Different modalities for management of peripheral corneal ulcer
Authors: Elshahawy Sarah I.I. , Nasef Mohamed H. , Shaheen Mohamed A.E. , Elshorbagy Mohamed S. 
Published: May 2023

Background
The peripheral cornea has unique features, which make it more vulnerable to inflammatory reactions and necrosis. Peripheral corneal ulcer is caused by various infectious and noninfectious ocular and systemic diseases. It may impair vision by inducing astigmatism and ulcer progression to the center or threaten the eyeball integrity by spontaneous perforation. So, early diagnosis and proper treatment prevent blindness.

Aim
To evaluate different modalities for management of peripheral corneal ulcer.

Patients and methods
In this prospective study, 30 eyes of 29 patients having peripheral corneal ulcer were evaluated and treated with medical treatment and surgical intervention as adjunctive therapy in resistant cases. The duration of the study was 6 months with a follow-up period of 3 months.

Results
Of 30 eyes, 14 responded to medical treatment, with complete epithelial healing ranging from 2 to 6 weeks, with a mean of 3.36 ± 1.34 weeks. On the contrary, 16 of 30 eyes were resistant within 2 weeks and underwent surgical interference. A total of seven eyes were managed by amniotic membrane transplantation, and nine eyes were treated with tectonic keratoplasty. Time of healing ranged from 4 to 14 weeks, with a mean of 9.38 ± 3.91. All eyes showed anatomically successful outcomes.

Conclusion
Mild infectious peripheral keratitis heals on medical treatment. Cases of moderate infectious peripheral keratitis with history of diabetes mellitus or exposure keratitis need amniotic membrane transplantation as adjunctive therapy. Severe noninfectious cases with history of rheumatoid arthritis or Mooren’s ulcer need systemic treatment and tectonic keratoplasty.
Assessment of level of care of diabetic patients with nephropathy in predialysis stage 4 in Tanta
Authors: Elmoghany Ahmed A.A. , El-Naggar Mohammed H. , El-Sherbiny Ali , Ibrahim Ingy A.W. 
Published: May 2023

Background
Stage 4 chronic kidney disease (CKD) in comparison with earlier stages of CKD is associated with higher morbidity, mortality, and costs, and current guidelines recommend greater intensity of care for patients with stage 4 disease.

Aim
Our study assessed the level of care of patients with diabetic nephropathy (DN) in predialysis stage (CKD stage 4) in Tanta.

Patients and methods
A total of 257 patients experiencing DN stage 4 from Tanta were subjected to a questionnaire sheet that included age; duration of diabetes; time of diagnosis of DN; treatment of hypertension; patient diet; antidiabetic drugs; level of serum creatinine; estimated glomerular filtration rate; hemoglobin level; serum levels of Ca, Ph, parathyroid hormone, Na, K, and HCO3; lipid profile; statin therapy; and hemoglobin A1c. The data collected were compared with Kidney Disease: Improving Global Outcomes clinical practice guideline for the evaluation and management of CKD.

Results
Of the 257 patients, 27.6% were type 1 diabetics and 72.4% were type 2. The mean duration of diabetes was 12.43 years (±6.388). Overall, 29.9% had uncontrolled elevated blood pressure, of whom 27.2% were on no antihypertensive drugs. Renin-angiotensin-aldosterone system blockage agents were used in 52.1% of patients. Overall, 57.2% had good control of diabetes. Dyslipidemia was found in 49.4% patients of them 62.2% patients were on no statin therapy. Hypocalcemia was found in 5.4% patients, hyperphosphatemia was found in 12.4% patients, 4.7% had secondary hyperparathyroidism, 79.8% had bicarbonate level below normal range, 9.7% had mild elevate potassium level, and 20.4% had anemia.

Conclusion
Our patients reached stage 4 early after few years of diabetes, and parameters that need more level of care include hypertension, diabetes, treatment used for diabetes, dyslipidemia, and acidosis.
“Rule of Five” in Ureteral Dilatation and its Role in Ureteral Access Sheath Placement during Retrograde Intrarenal Surgery
Authors: Venkatachalapathy Vigneswara Srinivasan Sockkalingam , Palathullil Datson George , Abraham George Palathullil 
Published: May 2023

Purpose:
Sequential ureteral dilatation facilitates placement of ureteral access sheath during retrograde intrarenal surgery. The authors adopted some improvisations in conventional sequential ureteral dilatation methods to achieve improved ureteral accommodation and prefer to call the sequential ureteral dilatation performed with these improvisations as “Rule of five” (ROF) ureteral dilatation. The objective of the article was to describe the “ROF” ureteral dilatation technique and share the preliminary experience with the technique.

Materials and Methods:
“ROF” ureteral dilatation involves repetitive dilatation of ureter for five times by 10 Fr ureteral dilator, with each dilatation lasting for 5 s. The technique was used in patients who underwent retrograde intrarenal surgery for renal calculi and in whom 12 Fr ureteral dilator passage and 9.5/11.5 Fr ureteral access sheath placement was not possible by conventional sequential ureteral dilatation methods. Preliminary efficacy and safety outcomes were reported.

Results:
“ROF” ureteral dilatation was performed in 14 renal units. Ureteral access sheath placement was successful in 10 renal units (71.4%) and unsuccessful in 4 renal units (28.6%). Ureteral access sheath associated low-grade ureteral wall injury was noted in 2 renal units (14.3%). None had new onset hydroureteronephrosis in follow-up ultrasonography and all patients were asymptomatic in the follow-up period.

Conclusion:
“ROF” ureteral dilatation is an improvisation of conventional sequential ureteral dilatation. It facilitates successful and safe ureteral access sheath placement in a proportion of patients undergoing sequential ureteral dilatation.
Design and Analysis of Urban Land Lease Price Predicting Model Using Batch Gradient Descent Algorithm
Authors: Berhane Niguse Kifle 
Published: May 2023

Standard and econometric models are appropriate for causal relationships and interpretations among facets of the economy. But with prediction, they tend to over-fit samples and simplify poorly to new, undetected data. This paper presents a batch gradient algorithm for predicting the rice of land with large datasets. This paper uses a batch gradient descent algorithm to minimize the cost function, iteratively with possible combinations of the number of iterations i=1500 and learning rates, of 0.01, 0.02, 0.03 for the linear regression case and i = 100, 0.3, 0.2, and 0.1 for the multiple regression case. The paper uses Octave-4.0.3(GUI) for implementing 129 samples of the lease bid price of Mekelle City as training sets and feature inputs of two and three for linear regression and multiple regressions. Using = 0.01, the best fitting parameters found by training the dataset are with a cost of J=67.82. The model predicts with an accuracy of 92.6% using LR and 91.15% using MLR for a 315 m2 land size. As the learning rate increases, the fitting parameters increase and decrease respectively with an equal cost but the model’s prediction error increments slowly. With multiple regression, as the learning rate lowers, the model under fits prediction drastically (with an accuracy of 60%) with gradient descent and predicts with an accuracy of 91.5% with ordinary equations. So, prediction with ordinary equations provides the best fit for multiple regressions.
Conceptualization of Covid-19 in New Life Post Covid-19 Pandemic: A Semantic Cognitive Appoach
Authors: Bulan Deanty Rumandang , Silaswati Diana , Hermawan Dani 
Published: May 2023

At the time of writing, the government of Republic of Indonesia releases the warning the danger of new variant of Covid-19, Omicron XBB. Long after people get used to live on “the new life after pandemic”, we might perceive that the danger of Covid-19 has no longer considered as threatening as it used to before. Looking at how people perceive their life after new normal, this study aims to describe the conceptualization of Covid-19 newest variation, Omicron XBB, in online mass media. This study is conducted using a qualitative descriptive method that aims to depict how online mass media conceptualize the newest variation of Covid-19, Omicron XBB today. The data were gained from the news headline on online mass media in Indonesia, ranging from October to mid Desember 2022, and were analysed using the framework of the Conceptual Metaphor Theory (CMT). The results show that the Omicron XBB is no longer conceptualized as a war but later it is more depicted as a mobile thing/human.
INDONESIAN – ENGLISH CODEMIXING USED ON SELECTED TIKTOK ACCOUNT
Authors: Ndruru Sindy Claudia M. , Laia Surdini , Siahaan Hiace Vega Fernando 
Published: May 2023

Tujuan dari penelitian ini adalah untuk menganalisis penggunaan Campur Kode pada akun tiktok terpilih. Tujuan dari penelitian ini adalah untuk mengetahui jenis-jenis campur kode yang ditemukan pada akun TikTok terpilih, mengetahui jenis yang paling dominan dan alasan penggunaan jenis campur kode yang paling dominan pada akun TikTok terpilih. Dalam penelitian ini, penulis menggunakan desain deskriptif kualitatif. Penulis menggunakan teori Muysken ada tiga jenis campur kode yaitu insertion, Alternatin, dan Congruent Lexicalisation. Setelah menganalisis data, penulis menyimpulkan bahwa jenis campur kode yang paling dominan adalah Penyisipan dengan prosentase 52,4%, kemudian alternesi dengan prosentase 28,6% dan yang terakhir adalah leksikalisasi kongruen dengan prosentase 19%. Alasan jenis campur kode yang paling dominan pada akun tiktok yang dipilih adalah penyisipan karena bahasa Indonesia adalah bahasa ibu pemilik akun tiktok sehingga ketika mereka berbicara menggunakan campur kode mereka hanya memasukkan beberapa bahasa lain ke dalam kalimat, agar terlihat bergengsi karena pencampuran bahasa Inggris ketika seseorang berbicara bahasa Indonesia terlihat lebih keren dan menarik perhatian orang lain.
Cognitive Commitmen Behavioral Therapy Sebagai Penangkal Kecanduan Gagdet Pada Remaja Pada Masa New Normal Covid 19 Di Panti Asuhan St. Louis De Monfort Sikumuna Kota
Authors: Gero Sabina , Hamu Antonia Helena 
Published: May 2023

Pandemi covid 19 membawa perubahan kebijakan didunia pendidikan. Kebijakan tersebut membuat remaja sekolah tidak melakukan tatap muka dikelas dan menggantikan dengan metode pembelajaran jarak jauh berbasis internet atau daring yang banyak menggunakan Gagdet. Remaja bebas menggunakan gagdet untuk mengakses internet. Remaja lebih rentan terhadap kecanduan smartphone daripada orang dewasa. Tujuan dari pengabdian masyarakat ini adalah Pemberdayaan remaja dengan memberikan Cognitive commitment Behaviora therapy (CCBT) sebagai penanggkal kecanduan gadget pada remaja di Panti Asuhan St. Louis De Monfort, Sikumana Kupang. ceramah, bermain, small group discussion dan demonstrasi dengan didahului dan diakiri dengan pre test dan post test menggunakan kuisioner Kecanduan internet. Pemberian psikotherapy CCBT 5 sesi dan monitoring evaluasi. Kegatan ini dilaksanakan pada 5 Mei samapi 5 Juni 2021. Remaja sebanyak 62 orang. Hasil: Kecanduan gadget tingkat berat dari awal 52% turun menjadi 12%, Tingkat sedang dari 24% menjadi 52%, ringan 16% menjadi 20% dan normal 8% menjadi 16%. Remaaja yang kecanduan berat disarankan rujuk ke psikiatrik dan yang tingkat sedang meneruskan mencatat dalam Buku Pekerjaan rumah kegiatan pengalihan remaja dan di dampingi oleh pengasuh panti memonitor ketergantungan remaja dengan format yang tersedia dalam buku Kerja. Remaja sangat kooperatif dalam psikotherapi ini sehingga perlu dilkaukan secara berkala agar remaja dapat menggunakan gadget dengan bijak
Kelas Ibu Hamil Dalam Upaya Deteksi Dini Tanda Bahaya Kehamilan Di Desa Kuanheun Kabupaten Kupang Provinsi Nusa Tenggara Timur
Authors: Betan Mariana Oni 
Published: May 2023

Hasil Riset Kesehatan Dasar 2018 menunjukkan komplikasi kehamilan berupa bengkak pada kaki disertai kejang di Provinsi Nusa Tenggara Timur masih tinggi (4,7%) dibandingkan dengan proporsi nasional (2,7%). Hipertensi dalam kehamilan menjadi penyebab kelahiran bayi dengan berat badan lahir rendah. Profil Dinas Kesehatan Kabupaten Kupang tahun 2013 menunjukkan Kecamatan Kupang Barat menempati urutan ketiga persentase bayi berat lahir rendah tertinggi (12,30%) dan kasus malaria positif tertinggi kedua (100 kasus). Desa Kuanheun, salah satu desa di Kecamatan Kupang Barat, merupakan desa mitra Jurusan Keperawatan Poltekkes Kemenkes Kupang. Empat orang ibu hamil di desa ini termasuk dalam kategori berisiko. Pelaksaan kelas ibu hamil di desa ini bertujuan untuk meningkatkan pengetahuan dan sikap ibu hamil terhadap tanda-tanda bahaya kehamilan. Metode yang digunakan adalah penyuluhan. Kegiatan dilaksanakan di Puskesmas Pembantu yang dihadiri oleh 21 orang ibu hamil. Pengetahuan ibu mengalami peningkatansetelah mengikuti kelas ibu hamil. Nilai mean meningkat dari 39.00 menjadi 72.05 ((p-value = 0.001). Sikap ibu juga meningkat dimana nilai meanmeningkat dari 43.67 menjadi 75.48 ((p-value = 0.000). Kegiatan promosi kesehatan melalui kelas ibu hamil harus diterapkan di fasilitas kesehatan desa. Perlu adanya dukungan dari pemerintah desa dan masyarakat dalam menyiapkan fasilitas pelaksanaan kelas ibu hamil. Kegiatan kelas ibu hamil sebaiknya melibatkan keluarga.
Penyuluhan Kesehatan Nutrisi Pada Ibu Hamil Di Pmb Yuliyanti, Str.Keb. Teluk Betung Bandar Lampung
Authors: Astuti Susana Dwi , Hidayah Nanik 
Published: May 2023

Kesehatan ibu Hamil dipengaruhi pada supan nutrisi yang seimbang. Akibat kekurangan nutrisi dapat berakibat ibu dan janin tidak sehat selama ibu menjalani kehmilanya. Untuk menjaga kesehatan ibu dibutuhkan gizi yang seimbang selain baik untuk kesehatan ibu juga sangat bermanfaat untuk perkembangan janin ibu. Kehamilan yang tidak sehat dapat berakibat yang tidak baik untuk persiapan persalian, kekurangan nutrisi pada ibu hamil bisa berakibat ibu terkena anemia atau hypertensi apabila kecukupan gizi ibu tidak terpenuhi dan dapat berakibat terjadi Abortus serta Berat Bayi Lahir Rendah ( BBLR). Metode pemyuluhan dilakukan dengan cara Komunikasi Interpersonal pada Ibu hamil yang berjumlah 10 orang. Pelaksanaan penyuluhan di adakan di PMB Yulianti, STRKeb Di teluk Betung Bandar Lampung. Dengan media penyuluhan menggunakan Bener, Lembar Balik, dan Lifleat. Hasil dari Penyuluhan Ibu dapat memahami pentingnya Nutrisi Pada Ibu hamil dan Baik untuk perkembangan janin yang dikandungnya. Pentingnya Nutrisi Pada Ibu Hamil untuk menjaga keseimbangan kebutuhan Gizi pada Ibu hamil dan janin
INVESTIGATION OF THE MELANIN INSTAPHYLOCOCCUS AUREUS ISOLATED FROM PATIENTS WITH URINARY TRACT INFECTIONS.
Authors: Al-Ameri Kadhim H. A , Nasser Ashjan Agar 
Published: May 2023

The current study included isolating Staphylococcus aureus from the urine of men with urinary tract infections, where 17 isolates belonging to this species were obtained, which were diagnosed traditionally and by polymerase chain reaction. Then, the ability of the isolates to produce melanin was tested, as it is a substance that has great medical benefits, as it can be isolated and used as an antibacterial and antifungal, it has many other benefits. All isolates were melanin-producing, but the best of them were isolates 1, 2, 3and 10, which gave melanin amount of 3.1, 2.8, 3, and 2.9 mg/L, respectively, and gave a dry weight of 8.8, 6.5, and 6.1and 3.6 mg/l. Nitrogen sources gave close amounts of melanin, as follows: soybeans produced melanin with an amount of 2.7, yeast extract 2.6, and peptone 2.65 mg/l, while the best carbon sources culture medium was starch2.8 mg/l, then glucose came after that with 2.6 mg/l, then glycerol, maltose, fructose, sucrose, dextrose, and mannitol, with a yield of 2.4, 2.2, 2.2, 1.7, and 1.5 mg/l, respectively. The best temperature for melanin production was 35℃, followed by 30℃, then 25℃, then 40℃, then 20℃, with a melanin production amount of, 2.8, 2.3, 1.9, 1.7 and 1.1mg\l respectively. As for the pH, the best was 7, followed by 6, then 8, followed by 5, then 4 with melanin amount of 2.7,2.2, 1.7,1.7 and 1.3 mg\lrespectively.
Stand-up Comedy and Contemporary Feminisms
Authors: Tomsett Ellie 
Published: May 2023

What are the barriers to women’s participation in live comedy, and how these barriers are maintained in the digital era?
In this book, Ellie Tomsett considers how the origins of stand-up comedy still impact on current live comedy production, and explains how the contemporary stand-up scene still reflects wider societal stereotypes about the capabilities of women.
Using primary data collected from women-only comedy nights and immersive research with the UK Women in Comedy Festival in Manchester, Tomsett analyses examples of stand-up performed by contemporary comedians - including Bridget Christie, Lolly Adefope, Luisa Omielan and Ava Vidal - and questions how these performances relate to conceptions of feminist and postfeminist humour, as well as notions of backlash against contemporary feminisms. She focuses on live comedy that is explicitly feminist to consider how social attitudes to women, the increasing visibility of female labour outside the home, and the emergence of multiple (and sometimes contradictory) feminisms has influenced the comedy produced by women comedians in 21st century Britain.
Newly-developed De Cordovaâ€™s Formula for Calculation of LDL Cholesterol in Bangladeshi Population
Authors: Nasrin Nadia 
Published: May 2023

Raised serum LDL cholesterol is an important modifiable risk factor for the development of atherosclerosis and cardiovascular disease. So the management ofÂ dyslipidaemia is mostlyÂ based on the concentration of LDL cholesterol. Friedewaldâ€™s formula is commonly used method to estimate LDL cholesterol in most clinical laboratories. However, this formula cannot reflect the actual figure of LDL cholesterol. In 2013, de Cordova developed a new simple formula to calculate LDL cholesterol without using serum TG which is said to be more accurate than Friedewaldâ€™s formula. The present study was designed to compare the formula-based calculated LDL cholesterol (Friedewaldâ€™s formula and de Cordovaâ€™s formula) with directÂ homogenousÂ estimation. The objective of the present study was to evaluate of applicability of de Cordovaâ€™s formula for calculation of LDL cholesterol. By using non-probability sampling technique, 460 individuals were enrolled in the study who were attending in the one-point collection centre of BSMMU for lipid profile estimation. Subjects were categorized as normolipidaemic individuals and dyslipidaemic patients. Serum TC, TG, HDL cholesterol and LDL cholesterol were measured by direct automated method. LDL cholesterol was also calculated by Friedewaldâ€™s formula and de Cordovaâ€™s formula. Results were expressed as mean Â± SD. Comparison was done by Pearsonâ€™s correlation test, agreement was done by BlandAltman agreement test between measured and calculated LDL cholesterol. The mean Â± SD of measured LDL cholesterol was 132.99 Â± 36.65 mg/ dL. LDL cholesterol calculated by Friedewaldâ€™s formula and de Cordovaâ€™s formula were 121.39 mg/dL and 116.81 mg/dL respectively. The limits of agreement between measured LDL cholesterol (direct method) and calculated LDL cholesterol by de Cordovaâ€™s formula were lowest and agreement was better for all dyslipidaemic subjects. de Cordovaâ€™s formula showed better agreement with measured LDL cholesterol (direct method) than Friedewaldâ€™s formula for approximate calculation of LDL cholesterol without using triglycerides.Keywords: LDL cholesterol,Â de Cordovaâ€™sÂ formula, Friedewaldâ€™s formula
Edeka Minden setzt voll auf Bio-LNG
Authors: Bökamp Lena , Tewes Werner 
Published: May 2023

Mit dem Schritt, die ganze Lkw-Flotte auf einen Betrieb mit Bio-LNG umzustellen, läutet Edeka Minden ein neues Zeitalter in der Logistik ein. Das insgesamt 200 Mio. Euro schwere Investitionspaket zeigt, welchen Stellenwert CO₂-Einsparungen im Handel haben – und welches Potenzial kurzfristig in Bio-LNG steckt.