bluuebunny/crossref_metadata_2025_split huggingface dataset:
Production, consumption, and market supply of edible crickets: insights from East Africa
Authors: Musungu Arnold L. , Muriithi Beatrice W. , Ghemoh Changeh J. , Nakimbugwe Dorothy , Tanga Chrysantus M. 
Published: August 2023

AbstractGlobally, crickets are gaining recognition as a valuable alternative protein source for human consumption due to their lower resource requirement and ecological footprint compared to traditional livestock. In this paper, we examine strategies that may expedite the sustainable domestication of crickets as a food source. Using survey data from 306 households in western Kenya, we find that supplying cricket production starter kits, granting access to credit facilities, encouraging participation in farmer groups, and fostering partnerships can enhance the adoption of cricket farming. Moreover, we provide new evidence that institutional training significantly increases cricket yields while embracing cricket consumption (i.e. entomophagy) increases market supply. These findings underscore the importance of technical training, provision of production starter kits, and raising awareness about entomophagy to achieve sustainable mass production and adoption of cricket farming.
Magnetospirillum magneticum triggers apoptotic pathways in human breast cancer cells
Authors: Menghini Stefano , Vizovisek Matej , Enders Jonathas , Schuerle Simone 
Published: August 2023

AbstractThe use of bacteria in cancer immunotherapy has the potential to bypass many shortcomings of conventional treatments. The ability of anaerobic bacteria to preferentially accumulate and replicate in hypoxic regions of solid tumors, as a consequence of bacterial metabolic needs, is particularly advantageous and key to boosting their immunostimulatory therapeutic actions in situ. While several of these bacterial traits are well-studied, little is known about their competition for nutrients and its effect on cancer cells which could serve as another potent and innate antineoplastic action. Here, we explored the consequences of the iron-scavenging abilities of a particular species of bacteria, Magnetospirillum magneticum, which has been studied as a potential new class of bacteria for magnetically targeted bacterial cancer therapy. We investigated their influence in hypoxic regions of solid tumors by studying the consequential metabolic effects exerted on cancer cells. To do so, we established an in vitro co-culture system consisting of the bacterial strain AMB-1 incubated under hypoxic conditions with human breast cancer cells MDA-MB-231. We first quantified the number of viable cells after incubation with magnetotactic bacteria demonstrating a lower rate of cellular proliferation that correlated with increasing bacteria-to-cancer cells ratio. Further experiments showed increasing populations of apoptotic cells when cancer cells were incubated with AMB-1 over a period of 24 h. Analysis of the metabolic effects induced by bacteria suggest an increase in the activation of executioner caspases as well as changes in levels of apoptosis-related proteins. Finally, the level of several human apoptosis-related proteins was investigated, confirming a bacteria-dependent triggering of apoptotic pathways in breast cancer cells. Overall, our findings support that magnetotactic bacteria could act as self-replicating iron-chelating agents and indicate that they interfere with proliferation and lead to increased apoptosis of cancer cells. This bacterial feature could serve as an additional antineoplastic mechanism to reinforce current bacterial cancer therapies.
Digital inpainting of mural images based on DC-CycleGAN
Authors: Xu Zhigang , Zhang Chenmin , Wu Yanpeng 
Published: August 2023

Abstract
Located in Dunhuang, northwest China, the Mogao Grottoes are a cultural treasure of China and the world. However, after more than 2000 years of weathering and destruction, many murals faded and were damaged. This treasure of human art is in danger. Mural inpainting through deep learning can permanently preserve mural information. Therefore, a digital restoration method combining the Deformable Convolution (DCN), ECANet, ResNet and Cycle Generative Adversarial Network (CycleGAN) is proposed. We name it DC-CycleGAN. Compared with other image digital inpainting methods, the proposed DC-CycleGAN based mural image color inpainting method has better inpainting effects and higher model performance. Compared with the current repair network, the Frechet Inception Distance (FID) value and the two-image structural similarity metric (SSIM) value are increased by 52.61% and 7.08%, respectively. Image color inpainting of Dunhuang murals can not only protect and inherit Chinese culture, but also promote academic research and development in related fields.
Alactic base excess predicts the use of renal replacement therapy in patients with septic shock
Authors: Díaz Jesús S. Sánchez , Moguel Karla Gabriela Peniche , Gaxiola Fabiola Buelna , Ruiz José M. Reyes , Nieto Orlando R. Pérez , Sánchez María V. Calyeca 
Published: August 2023

Abstract
Background
Alactic base excess (ABE) is a novel biomarker that estimates the renal capability of handling acid–base alterations during the sepsis. Hence, the aim of this study was to evaluate the use of ABE to predict the renal replacement therapy (RRT) in patients with septic shock.

Methods
A total of 164 patients admitted to the intensive care units with a diagnosis of septic shock according to the third international consensus on sepsis and septic shock (Sepsis-3) were included. This study was retrospective, single center, and conducted between January 1, 2016, and December 31, 2020. The individuals were stratified in patients who did [n = 68] or did not [n = 96] receive the RRT. The diagnostic performed of the variables for the classification into patients who required RRT was evaluated by receiver operating characteristic (ROC) analysis and area under curve (AUC) was calculated. Univariate and multivariate logistic regression models were used to identify risk factors for RRT.

Results
The median age of the patients was 59 years and female sex (51.8%) predominated. ABE (odds ratio [OR] 1.2270, [95% confidence interval [CI] 1.0453–1.4403], p = 0.0124) and urea (OR 1.0114, [95% CI 1.0053–1.0176], p = 0.0002) were associated with risk of RRT. HCO3− (OR 0.6967, [95% CI 0.5771–0.8410], p = 0.0002) was a protective factor of RRT. ABE (AUC = 0.649, p < 0.0008), HCO3− (AUC = 0.729, p < 0.0001), and urea (AUC = 0.76, p < 0.0001) had a cutoff point of ≤ − 5.7 mmol/L, ≤ 19.36 mmol/L and > 75 mg/dL, respectively.

Conclusion
Although HCO3− is associated with low risk, ABE and urea are independent risk factors for RRT in the patients with septic shock.
Reducing harm and promoting positive media use strategies: new perspectives in understanding the impact of preschooler media use on health and development
Authors: Fitzpatrick Caroline , Binet Marie-Andrée , Cristini Emma , Almeida Maíra Lopes , Bégin Mathieu , Frizzo Giana Bitencourt 
Published: August 2023

AbstractMost children grow up in homes with easy access to multiple screens. Screen use by children between the ages of 0 to 5 has become a worldwide preoccupation. In the present narrative review, we examine child and parent screen use and its contribution to physical, cognitive, and social developmental outcomes. As research has mostly focused on the adverse consequences of screen media, we aim to depict both the negative and the positive influences of screen usage. To provide a more nuanced portrait of the potential benefits and harms of screen use, we examine how consequences of media use vary according to the content of media (ex., educational, violent), context (ex., using screens during mealtimes), and the nature (ex., passive vs active use) of child screen use. Our review supports existing screen time guidelines and recommendations and suggests that media content, the context of use, and the nature of child use, as well as the parent’s own screen use, be considered clinically. Future research should seek to clarify how these dimensions jointly contribute to child screen use profiles and associated consequences. Finally, child sex, behavioral/temperamental difficulties, and family adversity appear to contribute to child screen use and its consequences and should be considered in future research. Suggestions for harm-reduction approaches are discussed.
How do drivers mitigate the effects of naturalistic visual complexity?
Authors: Kondyli Vasiliki , Bhatt Mehul , Levin Daniel , Suchan Jakob 
Published: August 2023

AbstractHow do the limits of high-level visual processing affect human performance in naturalistic, dynamic settings of (multimodal) interaction where observers can draw on experience to strategically adapt attention to familiar forms of complexity? In this backdrop, we investigate change detection in a driving context to study attentional allocation aimed at overcoming environmental complexity and temporal load. Results indicate that visuospatial complexity substantially increases change blindness but also that participants effectively respond to this load by increasing their focus on safety-relevant events, by adjusting their driving, and by avoiding non-productive forms of attentional elaboration, thereby also controlling “looked-but-failed-to-see” errors. Furthermore, analyses of gaze patterns reveal that drivers occasionally, but effectively, limit attentional monitoring and lingering for irrelevant changes. Overall, the experimental outcomes reveal how drivers exhibit effective attentional compensation in highly complex situations. Our findings uncover implications for driving education and development of driving skill-testing methods, as well as for human-factors guided development of AI-based driving assistance systems.
Magnetic resonance imaging manifestations of vascular complications in patients with acute invasive fungal rhinosinusitis
Authors: Abokoura Sameh , Youssef Ayda , Nada Ayman , Abdelhalim Heba Ahmed 
Published: August 2023

Abstract
Background
Owing to significant morbidity and mortality with the development of vascular complications in patients with acute invasive fungal rhinosinusitis (AIFRS), early identification, and rapid medical or surgical interventions that are essential for improving patients’ outcomes. For the purpose of presurgical mapping and management planning, magnetic resonance imaging (MRI) is essential for the early identification and improved delineation of disease extent.

Objective
To evaluate variable MRI manifestations in the detection of the vascular complications in patients with AIFRS and its impact on patients’ survival.

Methods
A retrospective study, included 24 patients with histopathological proven AIFRS to review the para nasal sinus MRI findings. MRI were evaluated for the sinus involvement and the extrasinus extension into the orbit and/or the brain. Vascular structures were assessed for the development of vascular complications, like ICA for thrombosis, attenuation or pseudoaneurysm, cavernous sinus and superior ophthalmic veins for thrombosis.

Results
Of the reviewed 24 patients, 16 had cavernous sinus thrombosis, 15 had ICA thrombosis, 10 had ophthalmic vein thrombosis, 4 had ICA attenuation and only two cases had pseudoaneurysm of the ICA. Vascular thrombosis was more common with mucormycosis with cavernous sinus and ophthalmic vein thrombosis which were significantly increased among non survivor patients (90%, 70%), as compared to the survivor patients (50%, 14.29%), with P = 0.04 and 0.005 respectively.

Conclusions
Vascular complications are common in patients with AIFRS. MRI is helpful in accurate detection of vascular complications in patients with AIFRS.
Pulmonary mycoses among pulmonary tuberculosis in Kebbi State North Western Nigeria
Authors: Danlami Mohammed Bashar , Adefowepo Adesina Muibi , Manga Sahabi Sule , Yahaya Tajudeen Olanrewaju , Mshelia Mari Bata , Kalgo Zaharaddin Muhammad 
Published: August 2023

Abstract
Background
Pathogenic fungi are the source of the fungal illness known as pulmonary mycosis. The prevalence of pulmonary mycoses among patients with pulmonary tuberculosis is continuously rising, despite improvements in the disease’s diagnosis, treatment, and management. Three hundred clinically confirmed patients with pulmonary tuberculosis were recruited for this study. Sputum samples were collected and analyzed to detect M. tuberculosis using the GeneXpert machine. Fungal elements were determined using microscopy, culture, and fungal biochemical analysis. Fungal isolates were confirmed using nested PCR with the internal transcribed sequence region of the ribosomal cistron of the fungal species.

Results
Of the 300 sputum samples analyzed, 50 (16.7%) patients had pulmonary tuberculosis. Fungi pathogens were found in 142 patients (47.3%), with 99/142 (71.2%) primary infections, and 40/139 (29.5%) secondary infections. Among the secondary infections, 33 (11%) were fungi coinfections with rifampicin-sensitive MTB coinfections, while 7 (2.3%) were fungi co-infected with rifampicin-resistant MTB. Candida albican was the most common fungus isolate, accounting for 44 (31.7%), while non-Candidal albicans accounted for only 2 (1.4%). Of the 99 species responsible for primary infection, 33 (23.7%) were Blastomyces precursors, 30 (21.6%) were Candida species, and 21 (15.1%) were Aspergillus fumigatus. The fungal pathogen with the highest frequency of secondary infection was Candida species 14 (10.1%), followed by Aspergillus fumigatus 11 (7.9%), then Blastomyces precursors, and then 09 (6.5%).

Conclusion
In conclusion, this study determined the prevalence rate of fungal pathogens among pulmonary tuberculosis patients. The most dominant species observed were Blastomyces species, which are seldom reported in Africa and Nigeria. The two others were Aspergillus and Candida species. The study showed that a high percentage of cases of this species, responsible for pulmonary mycosis, were misdiagnosed and treated as pulmonary tuberculosis. Thus, there is a need for improved surveillance and accurate diagnosis of pulmonary infections for proper treatment.
A design of new wind power forecasting approach based on IVMD-WSA-IC-LSTM model
Authors: Li Zhenhui , Xiang Shuchen 
Published: August 2023

AbstractThe wind power forecasting (WPF) technology can reduce the adverse impact of wind power grid connection. Based on the characteristics of wind power data, an algorithm based on improved variational mode decomposition (IVMD) and long short-term memory (LSTM) Network is proposed to predict the wind power, and hyper parameter optimization search of LSTM using Whale Swarm Algorithm with Iterative Counter (WSA-IC). Firstly, through correlation analysis, the characteristics of 10 different wind power data are screened, and two kinds of data with large correlation with wind power are determined as input of the mode. Secondly, IVMD is used to calculate the maximum envelope kurtosis, determine the best decomposition parameters of the variational mode decomposition (VMD), and the original wind power and wind speed sequences are decomposed to obtain the IMF with different time scales. Finally, to address the problems of difficult optimization of hyper parameter and difficulty in obtaining optimal solutions for LSTM neural network modes, the WSA-IC algorithm is proposed to optimize its key hyper parameter, and the IVMD-WSA-IC-LSTM forecasting mode is established to obtain the short-term forecasting results of wind power. The algorithm is tested with the data of China Longyuan Power Group Corporation Limited. Compared with other common forecasting approaches using same data, the mean absolute error (MAE) of the forecasting approach is reduced to 0.007859, the mean square error (MSE) is reduced to 0.00011, and the determination coefficient is improved to 0.998828, which has higher forecasting accuracy.
Matrisome AnalyzeR – a suite of tools to annotate and quantify ECM molecules in big datasets across organisms
Authors: Petrov Petar B. , Considine James M. , Izzi Valerio , Naba Alexandra 
Published: August 2023

ABSTRACT
The extracellular matrix (ECM) is a complex meshwork of proteins that forms the scaffold of all tissues in multicellular organisms. It plays crucial roles in all aspects of life – from orchestrating cell migration during development, to supporting tissue repair. It also plays critical roles in the etiology or progression of diseases. To study this compartment, we have previously defined the compendium of all genes encoding ECM and ECM-associated proteins for multiple organisms. We termed this compendium the ‘matrisome’ and further classified matrisome components into different structural or functional categories. This nomenclature is now largely adopted by the research community to annotate ‘-omics’ datasets and has contributed to advance both fundamental and translational ECM research. Here, we report the development of Matrisome AnalyzeR, a suite of tools including a web-based application and an R package. The web application can be used by anyone interested in annotating, classifying and tabulating matrisome molecules in large datasets without requiring programming knowledge. The companion R package is available to more experienced users, interested in processing larger datasets or in additional data visualization options.
CULTURAL AND EDUCATIONAL TOURISM AS A DIRECTION OF USING AND PROTECTING THE CULTURAL HERITAGE OF THE REPUBLIC OF CRIMEA
Authors: Ibragimov Ernest E. , Anokhin Viktor S. 
Published: August 2023

The article substantiates the role of cultural and educational tourism in the popularization of the cultural heritage of the Republic of Crimea, reflects the importance of cultural tourism for the formation of national consciousness of citizens, examines the main objects of cultural heritage of the region, identifies the problems and prospects of using the cultural heritage of the region in tourism.
Cultural heritage is the most important resource for regional development, including cultural and educational tourism, which can be considered as an effective factor contributing to familiarization with the cultural heritage of the region, therefore, research aimed at developing methodological foundations for a balanced interaction of cultural heritage management processes and the development of tourism activities based on its use is relevant.
The purpose of the study: to substantiate the importance of cultural and educational tourism in promoting the cultural heritage of the Republic of Crimea and to identify current problems of their use in tourism.
The methodological basis of the research is the philosophical principles of cognition; dialectical, logical and systematic approaches to the consideration of phenomena and processes, as well as general scientific methods: analysis and synthesis to substantiate theoretical propositions, generalization, systematic approach and formal logic to deduce the content of relevant concepts.
The preservation of cultural heritage and its rational use are crucial for the sustainable attraction of tourist flows and the improvement of socio-economic indicators of the region. The activation of cultural and educational tourism throughout the Crimean region can contribute to the development of other sectors of the tourism industry and, of course, will have a positive impact on the preservation of cultural heritage.
Evaluation of remote services and patient satisfaction - a qualitative study
Authors: Laskowski Jakub , Kister Klaudia , Mazur Magdalena , Rektor Natalia , Małolepsza Aleksandra , Zach-Źródlak Monika , Rosa Lidia , Czechowska Julia , Bronst Paulina , Szabrańska Anna 
Published: August 2023

BACKGROUND: Telemedicine is among the most modern branches of medicine. In the field of mental health, telepsychiatry makes it possible to replace the traditional conversation with a specialist with an e-visit. With the development of remote services, qualitative studies evaluating this type of service have begun to be conducted. The studies involve both patients and clinicians. The purpose of this study is to show the advantages perceived by patients who use telepsychiatry services, as well as concerns that may discourage further use of digital therapy. The study also includes an evaluation of telemedicine services.
Material and methods: The authors created a proprietary structured questionnaire that consisted of two parts. The first concerned sociodemographic data, while the second addressed the subject of patients' evaluation with the use of telepsychiatry services, possible difficulties during e-visits and satisfaction with this type of consultation. Before completing the survey, patients filled out informed consent. The survey was conducted from November 2022 to May 2023.
Results: The final group of respondents was formed by 432 people. The largest group of respondents were patients with the diagnosis: affective disorders - 24.07%. The vast majority of respondents - 81.94% - indicated the possibility of teleportation from anywhere in the world as the greatest advantage of telepsychiatry. Another advantage is not having to take time off from work or school - 78.94%. Major disadvantages included: limited treatment methods (71.07% of respondents), made it more difficult to build a therapeutic alliance 59.03%, privacy and cybersecurity concerns 43.06%. Overall, patients rate telepsychiatry well - 66% of respondents were satisfied.
Conclusions: Telepsychiatry is well rated among most patients. More research is needed to develop clear guidelines for digital therapy. Patients receiving remote therapy should be screened for the development of addiction to mobile devices and the Internet.
Network Externalities and Market Dominance
Authors: Akerlof Robert , Holden Richard , Rayo Luis 
Published: August 2023

We propose a monopoly and Stackelberg duopoly model for “new economy” markets—with a Beckerian S-shaped demand curve at its center—that allows for intermediate degrees of firm focality and consumer heterogeneity. Because of network externalities, firms compete for the dominant market share, rather than the marginal consumer. This leads to a type of limit pricing—from within, rather than from outside the market—where the nondominant firm captures a positive market share that serves as a consolation prize. We characterize how firms’ technologies, “consumer impulses” (which might be influenced by past sales, defaults, or advertising), and network externalities affect competition, and derive implications for firm strategy. Broadly speaking, we find that the dominant firm should adopt an aggressive “top-dog” stance (akin to, but not identical to, that of a firm seeking to deter rival entry), whereas the nondominant firm should respond with an accommodating “puppy-dog” approach. This paper was accepted by Alfonso Gambardella, business strategy. Funding: R. Akerlof received financial support from the Institute for New Economic Thinking.