bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphate NIMA-Related Kinase 2-Dependent Epigenetic Pathways in Dorsal Root Ganglion Neurons Mediates Paclitaxel-Induced Neuropathic Pain
Authors: Hsieh Ming-Chun , Lai Cheng-Yuan , Cho Wen-Long , Lin Li-Ting , Yeh Chou-Ming , Yang Po-Sheng , Cheng Jen-Kun , Wang Hsueh-Hsiao , Lin Kuan-Hung , Nie Siao-Tong , Lin Tzer-Bin , Peng Hsien-Yu 
Published: February 2023

BACKGROUND:
The microtubule-stabilizing drug paclitaxel (PTX) is an important chemotherapeutic agent for cancer treatment and causes peripheral neuropathy as a common side effect that substantially impacts the functional status and quality of life of patients. The mechanistic role for NIMA-related kinase 2 (NEK2) in the progression of PTX-induced neuropathic pain has not been established.

METHODS:
Adult male Sprague-Dawley rats intraperitoneally received PTX to induce neuropathic pain. The protein expression levels in the dorsal root ganglion (DRG) of animals were measured by biochemical analyses. Nociceptive behaviors were evaluated by von Frey tests and hot plate tests

RESULTS:
PTX increased phosphorylation of the important microtubule dynamics regulator NEK2 in DRG neurons and induced profound neuropathic allodynia. PTX-activated phosphorylated NEK2 (pNEK2) increased jumonji domain–containing 3 (JMJD3) protein, a histone demethylase protein, to specifically catalyze the demethylation of the repressive histone mark H3 lysine 27 trimethylation (H3K27me3) at the Trpv1 gene, thereby enhancing transient receptor potential vanilloid subtype-1 (TRPV1) expression in DRG neurons. Moreover, the pNEK2-dependent PTX response program is regulated by enhancing p90 ribosomal S6 kinase 2 (RSK2) phosphorylation. Conversely, intrathecal injections of kaempferol (a selective RSK2 activation antagonist), NCL 00017509 (a selective NEK2 inhibitor), NEK2-targeted siRNA, GSK-J4 (a selective JMJD3 inhibitor), or capsazepine (an antagonist of TRPV1 receptor) into PTX-treated rats reversed neuropathic allodynia and restored silencing of the Trpv1 gene, suggesting the hierarchy and interaction among phosphorylated RSK2 (pRSK2), pNEK2, JMJD3, H3K27me3, and TRPV1 in the DRG neurons in PTX-induced neuropathic pain.

CONCLUSIONS:
pRSK2/JMJD3/H3K27me3/TRPV1 signaling in the DRG neurons plays as a key regulator for PTX therapeutic approaches.
The Media Swirl
Authors: Vernallis Carol 
Published: February 2023

From fan-generated content on TikTok to music videos, the contemporary media landscape is becoming ever more vast, spectacular, and intense. In The Media Swirl Carol Vernallis examines short-form audiovisual media—Beyoncé’s Lemonade, brief sequences from Baz Luhrmann’s The Great Gatsby, TikTok challenges, YouTube mashups, commercials, and many other examples—to offer ways of understanding digital media. She analyzes music videos by Beyoncé, Lady Gaga, Janelle Monáe, Kendrick Lamar, Anderson .Paak, and others to outline how sound and image enhance each other and shape a viewer’s mood. Responding to today’s political-media landscape through discussions of Fox News and Presidential inaugurations, Vernallis shows how a media literacy that exceeds newscasts and campaign advertising is central to engaging with the democratic commons. Forays into industry studies, neuroscience, and ethics also inform her readings. By creating our own content and knowing what corporations, the wealthy, and the government do through media, Vernallis contends, we can create a more just world.
Association of Postoperative Drift in Hemoglobin With Mortality After Brain Tumor Craniotomy
Authors: Zhang Yu , Jia Lu , Tian Yixin , He Jialing , He Miao , Chen Lvlin , Hao Pengfei , Li Tiangui , Peng Liyuan , Chong Weelic , Hai Yang , You Chao , Fang Fang 
Published: February 2023

BACKGROUND:
Postoperative downward drift in hemoglobin (Hb) concentration may be associated with complications and death, even if nadir Hb remains more than the red blood cell transfusion threshold of 7 g/dL.

OBJECTIVE:
To assess whether postoperative Hb drift in patients undergoing brain tumor craniotomy influences mortality in the immediate perioperative period.

METHODS:
This retrospective cohort study included patients undergoing craniotomy for brain tumors. We defined no postoperative Hb decrease, mild decrease, moderate decrease, and severe decrease as postoperative Hb drift of ≤25%, 26% to 50%, 51% to 75%, and >75%, respectively. The primary outcome was 30-day mortality after craniotomy.

RESULTS:
This study included 8159 patients who underwent a craniotomy for brain tumors. Compared with patients with no postoperative Hb drift, the odds of postoperative mortality at 30 days increased in patients with mild postoperative Hb drift (adjusted odds ratio [OR] 2.47, 95% CI 1.72-3.56), moderate drift (adjusted OR 6.56, 95% CI 3.42-12.59), and severe drift (adjusted OR 12.33, 95% CI 3.48-43.62). When postoperative Hb drift was analyzed as a continuous variable, for each 10% increase in Hb drift, the adjusted OR of postoperative mortality at 30 days was 1.46 (95% CI 1.31-1.63).

CONCLUSION:
In patients undergoing brain tumor craniotomy, a small postoperative Hb drift was associated with increased odds of postoperative mortality at 30 days, even if the nadir Hb level remained greater than the red blood cell transfusion threshold of 7 g/dL. Future randomized clinical trials of perioperative transfusion practices may examine the effect of both nadir Hb and Hb drift.
Energetic costs of bill heat exchange demonstrate contributions to thermoregulation at high temperatures in toco toucans (Ramphastos toco)
Authors: Chaves Jussara N. , Tattersall Glenn J. , Andrade Denis V. 
Published: February 2023

ABSTRACTBody temperature regulation under changes in ambient temperature involves adjustments in heat production and heat exchange rates between the animal and the environment. One mechanism involves the modulation of the surface temperature of specific areas of the body through vasomotor adjustment. In homeotherms, this thermoregulatory adjustment is essential for the maintenance of body temperature over a moderate temperature range, known as the thermal neutral zone (TNZ). The bill of the toco toucan (Ramphastos toco) has been described as a highly efficient thermal window and hypothesized to assist in the thermal homeostasis of this bird. Herein, we directly evaluated the contribution of heat exchange through the bill of the toco toucan and role of the bill in the delimitation of the TNZ. To do this, we measured metabolic rate (MR), via oxygen consumption, over a range of ambient temperatures from 0 to 35°C. MR measurements were made in birds with the bill intact and with the bill insulated. The limits of the TNZ did not differ between treatments, ranging from 10.8 to 25.0°C. The MR differed among treatments only at elevated temperatures (30 and 35°C), reaching 0.92±0.11 ml O2 g−1 h−1 (mean±s.d.) for the intact group and 1.13±0.13 ml O2 g−1 h−1 for the insulated group. These results indicate that although heat dissipation through the bill does not contribute significantly to widening of the TNZ, it may well be critically important in assisting body temperature regulation at higher temperatures extending above the upper limit of the TNZ.
Surface figure measurement tool based on a radial shearing interferometer using a geometric phase lens with various spherical wavefronts
Authors: Mi Park Hyo , Joo Ki-Nam 
Published: February 2023

We describe a compact radial shearing interferometer based on a geometric phase lens as a surface figure measurement tool. Based on the polarization and diffraction characteristics of a geometric phase lens, two radially sheared wavefronts are simply generated, and the surface figure of a specimen can be immediately reconstructed from the radial wavefront slope calculated with four phase-shifted interferograms obtained from a polarization pixelated complementary metal-oxide semiconductor camera. In order to increase the field of view, moreover, the incident wavefront is adjusted according to the shape of the target, which allows the reflected wavefront to become planar. By the combination of the incident wavefront formula and the measurement result by the proposed system, the whole surface figure of the target can be instantaneously reconstructed. As the experimental result, the surface figures of various optical components were reconstructed at the extended measurement area with less than 0.78 µm deviations, and it was confirmed that the radial shearing ratio was fixed independent of the surface figures.
The usefulness of change in CT score for evaluating the activity of Mycobacterium abscessus (Mab) pulmonary disease (Mab-PD)
Authors: Shinfuku Kyota , Hara Hiromichi , Takasaka Naoki , Ishikawa Takeo , Araya Jun , Kuwano Kazuyoshi 
Published: February 2023

Objectives
Semi-quantitative CT score is generally used for evaluating the disease status of Mycobacterium abscessus (Mab) Pulmonary disease (Mab-PD). However, its accuracy and clinical usefulness are limited, since the CT score is largely affected by coexisting lung disease. Hence, we hypothesized that numerical change in CT score during the observation period may be useful for evaluating disease activity of Mab-PD.

Methods
Patients diagnosed with Mab-PD based on the official ATS/ERS/ESCMID/IDSA statement at Jikei University Hospital and Jikei Daisan Hospital between 2015 January 1 and 2021 July 31 were included (n = 32). We reviewed the medical records, and bacteriological and laboratory data of the patients. Chest CT was performed at diagnosis in all 32 cases. In 18 cases, chest CT images within 4 years before diagnosis were available. The numerical change in CT score between two time points was calculated and the association of the CT scores with sputum Gaffky score and serum CRP was examined.

Results
CT score at diagnosis was not correlated with sputum Gaffky score nor serum CRP, while the difference of absolute value and change rate in CT score between at diagnosis and immediate past CT were well correlated with both sputum Gaffky score and serum CRP.

Conclusions
Chronological change in CT score may more precisely reflect the disease activity of airway mycobacterial burden and systemic inflammation in Mab-PD at the timing of diagnosis.
Biomarkers for prediction of neurological complications after acute Stanford type A aortic dissection: A systematic review and meta-analysis
Authors: Si Yi , Duan Weixun , Xie Jiangang , Duan Chujun , Liu Shanshou , Wang Qianmei , Zhao Xiaojun , Wu Dan , Wang Yifan , Wang Lingxiao , Li Junjie 
Published: February 2023

Background
The predictive value of biomarkers such as neuron specific enolase (NSE), S100B, neurofilament (NFL), interleukin-6 (IL-6), coagulation factor R, and D-Dimer (DD) after acute Stanford A type aortic dissection (AAAD) with neurological complications has recently gained much attention from the research community. However, results from these studies are conflicting. This meta-analysis is conducted to assess the relationship between the biomarkers and the risk of neurological complications after AAAD.

Methods
Two reviewers performed a systematic literature search across eight databases (CNKI, Wan Fang, VIP, CBM, PubMed, Web of Science, Cochrane Library, and EMBASE). The studies regarding biomarkers in AAAD patients published up to February 2022 were included. These studies were subjected to rigorous scrutiny and data extraction to determine the weighted mean difference (WMD) and the 95% confidence interval (CI), which were analyzed using the RevMan 5.4 and Stata software 14.0.

Results
A total of 12 studies including 360 cases with neurological complications and 766 controls were incorporated into our meta-analysis. WMD analysis showed that there was a higher NSE levels in AAAD patients with postoperative neurological complications compared with controls (WMD = 0.640, 95% CI: 0.205 ~ 1.075, P = 0.004 < 0.005), and the level of S100B was related to the 6 h and 24 h postoperative neurological complications (6 h: WMD = 0.64, 95% CI: 0.27 ~ 1.02, P = 0.0007 < 0.001; 24 h: WMD = 0.281, 95% CI: 0.211 ~ 0.351, P < 0.001). Moreover, S100B levels at 6 hours after operation were significantly higher than that at 24 hours (WMD = 0.260, 95% CI: 0.166 ~ 0.354, P < 0.001).

Conclusion
NSE and S100B are both candidate biomarkers to predict postoperative neurological complications in patients with AAAD. Other markers are also valuable when used in conjunction with clinical judgement. The findings accentuate the necessity of further research to establish standardized values for these biomarkers in predicting neurological complications.
STI testing and subsequent clinic attendance amongst test negative asymptomatic users of an internet STI testing service; one-year retrospective study
Authors: Ayinde Oluseyi , Jackson Louise , Phattey Jara , Ross Jonathan D. C. 
Published: February 2023

AimTo explore the characteristics of online STI test users, and assess the frequency and factors associated with subsequent service use following a negative online STI test screen in individuals without symptoms.MethodsOne-year retrospective study of online and clinic STI testing within a large integrated sexual health service (Umbrella in Birmingham and Solihull, England) between January and December 2017. A multivariable analysis of sociodemographic and behavioural characteristics of patients was conducted. Sexual health clinic appointments occurring within 90 days of a negative STI test, in asymptomatic individuals who tested either online or in clinic were determined. Factors associated with online STI testing and subsequent clinic use were determined using generalized estimating equations and reported as odds ratios (OR) with corresponding 95% confidence intervals (CI).Results31 847 online STI test requests and 40 059 clinic attendances incorporating STI testing were included. 79% (25020/31846) of online STI test users and 49% (19672/40059) of clinic STI test takers were asymptomatic. Online STI testing was less utilised (p<0.05) by men who have sex with men (MSM), non-Caucasians and those living in neighborhoods of greater deprivation. Subsequent clinic appointments within 90 days of an asymptomatic negative STI test occurred in 6.2% (484/7769) of the online testing group and 33% (4960/15238) for the clinic tested group. Re-attendance following online testing was associated with being MSM (aOR 2.55[1.58 to 4.09]—MSM vs Female) and a recent prior history of STI testing (aOR 5.65[4.30 to 7.43] ‘clinic tested’ vs ‘No’ recent testing history).ConclusionsSubsequent clinic attendance amongst online STI test service users with negative test results was infrequent, suggesting that their needs were being met without placing an additional burden on clinic based services. However, unequal use of online services by different patient groups suggests that optimised messaging and the development of online services in partnership with users are required to improve uptake.
Establishment of reference intervals for hematological parameters of adult population in the western region of Saudi Arabia
Authors: Borai Anwar , Ichihara Kiyoshi , Bahijri Suhad , Almasoud Abdulaziz , Tamimi Waleed , Abdulhadi Wail , Lingga Jamil , Bawazeer Ali , Abdelaal Mohammed , Boraie Sultanah , Alsofyani Abeer , Elsayid Mohieldin , Sannan Naif S. , Al-Shareef Ali S. , Khan Eman , Almohammadi Mohammed 
Published: February 2023

Background
Most of hematology laboratories in Saudi Arabia utilize the reference intervals (RIs) provided by instrument manufacturers. This study aimed to define RIs of hematological parameters for adult population in the western region of Saudi Arabia and to explore their specific features from an international perspective.

Method
This study was conducted according to the harmonized protocol of IFCC Committee on RIs and Decision Limits. Blood samples collected from 409 healthy Saudi males and females adults were analyzed for complete blood count (CBC) by using Cell-Dyn Sapphire analyzer and for iron profile by using Architect analyzers. The needs for RIs partitioned by sex and age was based on standard deviation ratio (SDR) and/or bias ratio (BR). RIs were derived parametrically with/without application of the latent abnormal values exclusion method (LAVE).

Results
Based on thresholds of SDR≥0.4 and/or BR≥0.57, RIs were partitioned by sex for red-blood cell count, hemoglobin, hematocrit, red cell distribution width, erythrocyte sedimentation rate, iron, transferrin, ferritin, eosinophil, platelet, plateletcrit, etc. Partitioning by age was not necessary for any of the analytes. LAVE procedure caused appreciable changes in RI limits for most erythrocyte and iron parameters but not for leukocyte parameters. Comparable to other non-IFCC studies on CBC RIs, the RBC and hematocrit (Ht) ranges have shifted to a higher side in both genders. After applying the LAVE method, the male and female RIs for Hb were 4.56 to 6.22 ×106/μL and 3.94 to 5.25 ×106/μL respectively while RIs for Ht were 40.2 to 52.0% and 33.6 to 44.5% respectively.

Conclusion
LAVE method contributed to reducing the influence of latent anemia in deriving RIs for erythrocyte related parameters. Using the up-to-date methods, the RIs of CBC determined specifically for Saudis will help to improve the interpretation of test results in medical decision making.
The magnitude, but not the duration of elevated central venous pressure is associated with mortality in sepsis patients: An analysis of the MIMIC-IV database
Authors: Chen Han , Gong Shu-Rong , Shang Xiu-Ling , Li Jun , Yu Rong-Guo 
Published: February 2023

Background
It is unclear whether the magnitude and duration of elevated central venous pressure (ECVP) greater than ten mmHg has the same impact on mortality in sepsis patients.

Methods
Critically ill patients with sepsis were identified from the Medical Information Mart for Intensive Care (MIMIC)-IV database. The duration and the magnitude of ECVP were calculated. Normalized ECVP load was defined as the ECVP load (the sum of ECVP value times its duration) divided by the total duration of ECVP. The primary endpoint was 28-day mortality. Kaplan-Meier survival analysis was used to compare survival between patients with high or low normalized ECVP load.

Results
A total of 1071 sepsis patients were included. Higher normalized ECVP load was associated with higher mortality rate; in contrast, the duration of ECVP was not associated with mortality. A linear relationship between normalized ECVP load and mortality was identified. Patients with higher normalized ECVP load had less urine output and more positive fluid balance.

Conclusion
The magnitude, but not the duration of ECVP, is associated with mortality in sepsis patients. ECVP should be considered as a valuable and easily accessible safety parameter during fluid resuscitation.
Intervención y tratamiento. Un acercamiento al escenario de las inserciones profesionales en la Unidad Penitenciaria N° 2 de la Ciudad de Santa Fe
Authors: Zuzulich María Florencia 
Published: February 2023

Este trabajo tiene como objetivo presentar un análisis exploratorio sobre las actividades de los equipos profesionales abocados al tratamiento penitenciario en la ciudad de Santa Fe durante el 2019. Para ello, se ocupa de las tareas de los Equipos de Acompañamiento para la Reintegración Social (EARS) de la cárcel de varones, y del Organismo Técnico Criminológico provincial (OTC).
Durante la investigación nos interesamos por recomponer los elementos que se relacionaban a un contexto de cambios que tenía a estos equipos en el centro de la disputa. Nuestra premisa asume que la constitución de los EARS en las cárceles de Santa Fe, tuvieron como propósito correrse de la tensión existente entre un “paradigma correccionalista” y el modelo de “cárcel depósito” a partir de una reforma en las políticas penitenciarias llevada a cabo entre 2008-2011. Sin embargo, el proceso de declinación de la reforma, los sucesivos cambios institucionales, así como el propio giro hacia políticas de tendencias punitivas, supuso adaptaciones, resistencias y/o tensiones en las funciones de los equipos que son el centro de interés de este trabajo.
Se utilizó un enfoque cualitativo, donde se emplearon distintas técnicas de investigación: por un lado, un análisis de contenido de normas y documentos de política pública y por otro entrevistas en profundidad a las integrantes de los equipos referidos. En este escrito describimos el escenario con el que nos encontramos en la investigación, las tensiones subyacentes y las tareas y sentidos de las prácticas profesionales en la cárcel de varones de la ciudad de Santa Fe.
Tanguito Montielero. Vínculos con el tango rioplatense de principios del Siglo XX
Authors: Franzoi Debarbora Leonel 
Published: February 2023

Durante los últimos años el tanguito montielero, una especie musical y coreográfica tradicional de la provincia de Entre Ríos (Argentina) captó la atención de varios realizadores audiovisuales, investigadores, intérpretes y compositores, quienes coinciden en que la especie no presenta rasgos en común con el tango porteño más allá de su denominación. A través del análisis Neutro y de la lectura crítica de documentos y entrevistas, el trabajo se propone demostrar la existencia de múltiples vínculos entre el tanguito montielero y el tango rioplatense que se interpretaba a principios del siglo XX. El objetivo es ofrecer un aporte a la fundamentación del uso del término “tanguito” y de sus características como especie musical. El presente artículo es el resultado de un trabajo realizado en el marco del seminario de postgrado: Metodología de la investigación en músicas tradicionales y populares a cargo del Doctor Enrique Cámara de Landa; dictado durante el ciclo 2021 en la Universidad Nacional del Litoral.
Monitoreo y dinámica territorial de la pandemia (Covid–19) en la provincia de Córdoba. Información para la toma de decisiones
Authors: Buffalo Luciana , Díaz María del Pilar , Rydzewski Ana Laura , Giovine Manuel , Capdevielle Julieta , Echecolanea Juan Manuel 
Published: February 2023

Reseña del Proyecto COVID FEDERAL COFECYT de la Región CENTRO- MINCYT.
Yo bailo, ell_s danzan
Authors: Cohen Veronica 
Published: February 2023

En este artículo me propongo considerar los alcances que tiene la descripción fenomenológica para esclarecer la experiencia de un cuerpo que danza. Parto de las siguientes hipótesis:
1) La distinción entre bailar y danzar permite clarificar la diferencia entre la experiencia de la danza en tanto vivida en el propio cuerpo, a la que llamo bailar, y la experiencia de la danza de un_ otr_, que llamo danzar.
2) L_s bailarin_s poseen un conjunto de conocimientos prácticos acerca de su práctica que se ponen en juego pre reflexivamente en todo bailar.
3) La fenomenología brinda una herramienta para hacer esos conocimientos compartibles.
En primer lugar, desarrollaré por qué propongo hacer uso de las posibilidades que da el español (así como también el italiano) de distinguir entre “bailar” y “danzar”. En segundo lugar, abordaré el concepto de conocimiento práctico de Alfred Schutz[1] y sus posibilidades para comprender la experiencia de l_s bailarin_s. En tercer lugar, intentaré esclarecer cómo la fenomenología puede otorgar un método para poder verbalizar y hacer compartibles los conocimientos prácticos de l_s bailarin_s a través de la descripción y ofreceré ejemplos de, por un lado, descripciones de mi propia práctica como bailarina y, por otro lado, otras realizadas por bailarin_s y filósof_s en una serie de talleres que realicé llamados “Describir la danza”.