bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular risk profiling among South Asian adults in Hong Kong: a latent class analysis
Authors: Chung Gary Ka-Ki , Lee Woohyung , Vargas Danna Camille , Sharma Bulbul , Sun Kai Sing , Hung Heidi , Tong Lee Sha , Tang Tsz Lui , Munir Hasiba , Wong Chi Yui , Pun Soniya , Chio Man Hin , Wong Eliza Lai-Yi , Dong Dong , Yeoh Eng-Kiong 
Published: January 2025

Abstract

Background
South Asians living in urbanized settings are facing disproportionate cardiovascular burden largely attributable to modifiable risk factors. Given the rapid surge in South Asian population in Hong Kong, this study aims to identify and distinguish clusters of cardiovascular risk profiles among community-dwelling South Asian adults.

Methods
Between June 2022 and December 2023, 1181 South Asian adults were recruited through territory-wide outreach health assessments on lifestyle, psychological distress, obesity, clinical cardiovascular conditions, and sociodemographic factors. Latent class analysis was performed to classify the cardiovascular profiles, followed by multinomial logistic regression to identify the sociodemographic characteristics across classes.

Results
Five latent classes were identified: low risk (19.6%), lifestyle risk plus distress (8.9%), obesity risk (33.4%), lifestyle risk plus distress with obesity (26.6%), and high clinical risk (11.4%). Apart from the higher clinical risk in older adults, women tended to cluster into classes with obesity, while men and the economically active were more likely in classes with poorer lifestyles and stress. Pakistani and Nepalese consistently exhibited higher risks compared to Indians, whereas the less educated tended to cluster into the high clinical risk class.

Conclusion
This study revealed distinct cardiovascular risk patterns and sociodemographic features within the South Asian community in Hong Kong. The heavy burden on obesity especially in women, lifestyle and psychological risks especially in men, and low overall physical activity level may be translated into a tremendous cardiovascular disease burden in the forthcoming decades, in particular among Pakistani and Nepalese as well as the socioeconomically disadvantaged.
Tumour DNA methylation markers associated with breast cancer survival: a replication study
Authors: Zarean Elaheh , Li Shuai , Wong Ee Ming , Makalic Enes , Milne Roger L. , Giles Graham G. , McLean Catriona , Southey Melissa C. , Dugué Pierre-Antoine 
Published: January 2025

Abstract

Background
Tumour DNA methylation has been investigated as a potential marker for breast cancer survival, but findings often lack replication across studies.

Methods
This study sought to replicate previously reported associations for individual CpG sites and multi-CpG signatures using an Australian sample of 425 women with breast cancer from the Melbourne Collaborative Cohort Study (MCCS). Candidate methylation sites (N = 22) and signatures (N = 3) potentially associated with breast cancer survival were identified from five prior studies that used The Cancer Genome Atlas (TCGA) methylation dataset, which shares key characteristics with the MCCS: comparable sample size, tissue type (formalin-fixed paraffin-embedded; FFPE), technology (Illumina HumanMethylation450 array), and participant characteristics (age, ancestry, and disease subtype and severity). Cox proportional hazard regression analyses were conducted to assess associations between these markers and both breast cancer-specific survival and overall survival, adjusting for relevant participant characteristics.

Results
Our findings revealed partial replication for both individual CpG sites (9 out of 22) and multi-CpG signatures (2 out of 3). These associations were maintained after adjustment for participant characteristics and were stronger for breast cancer-specific mortality than for overall mortality. In fully-adjusted models, strong associations were observed for a CpG in PRAC2 (per standard deviation [SD], HR = 1.67, 95%CI: 1.24–2.25) and a signature based on 28 CpGs developed using elastic net (per SD, HR = 1.48, 95%CI: 1.09–2.00).

Conclusions
While further studies are needed to confirm and expand on these findings, our study suggests that DNA methylation markers hold promise for improving breast cancer prognostication.
Maternal smoking during infancy increases the risk of allergic diseases in children: a nationwide longitudinal survey in Japan
Authors: Shigehara Kenji , Matsumoto Naomi , Tsuge Mitsuru , Uda Kazuhiro , Saito Yukie , Yashiro Masato , Yorifuji Takashi , Ikeda Masanori , Tsukahara Hirokazu 
Published: January 2025

Abstract

Background
The incidence of allergic diseases has been increasing in Japan. In particular, a serious decline in the age of onset of allergic rhinitis has been observed. Passive smoking from parental smoking has a significant impact on children’s health; however, it is difficult to restrict smoking in the home. While various studies have previously reported on the relationship between passive smoking and the development of allergic diseases in children. However, there have been no reports on passive smoking and allergic diseases on a national scale.

Methods
Using Japanese national longitudinal survey data (n = 38,444) for newborns born between May 10 and 24, 2010, we assessed parental smoking habits when their children were 6 months old and investigated the association with the development of allergic diseases until the age of 5.5 years. The risk ratios and 95% confidence intervals for the development of different allergic diseases were analyzed after adjusting for potential confounders using Poisson regression with a robust error variance.

Results
The risk ratio for developing allergic rhinitis/allergic conjunctivitis (AR/AC) in children was significantly higher in the maternal smoking groups ( ≦ 10 cigarettes/day; RR 1.15, 95% CI 1.02–1.30; ≧11 cigarettes/day; RR 1.16, 95% CI 0.93–1.44). Furthermore, associations were found between the maternal smoking group in the presence of paternal smoking and the risk of developing bronchial asthma ( ≦ 10, RR 1.33 95% CI 1.17–1.52; ≧11, RR 1.71 95% CI 1.38–2.1), food allergy ( ≦ 10, RR 1.36 95% CI 1.12–1.63; ≧11, RR 1.25 95% CI 0.84–1.86), atopic dermatitis ( ≦ 10, RR 1.42 95% CI 1.22–1.66; ≧11, RR 1.6 95% CI 1.2–2.13), and AR/AC ( ≦ 10, RR 1.21 95% CI 1.07–1.36; ≧11, RR 1.35 95% CI 1.09–1.67).

Conclusions
Maternal smoking during infancy increases the risk of developing AR/AC in children. Considering paternal smoking, maternal smoking further increased the risk of developing allergic diseases in children, suggesting that reducing parental smoking at home may reduce the risk of developing allergic diseases in children.
Identification of a pathogenic NHLRC1 variant in a consanguineous Pakistani family affected with severe and rapidly progressive Lafora disease
Authors: Aslam Zain , Zubaida Bibi , Khan Ranjha , Badshah Mazhar , Naeem Muhammad 
Published: January 2025

Abstract

Background
Autosomal recessively inherited progressive myoclonic epilepsy of Lafora, which is also known as Lafora disease, is a fatal neurodegenerative disorder. It affects individuals in late childhood or early adolescence and presents with symptoms of progressive mental and physical deterioration. This disease is caused by pathogenic genetic variants in either of two genes: EPM2A on chromosome 6q24, encoding laforin, or NHLRC1 (EPM2B) on chromosome 6p22, encoding malin.

Case presentation
In this study, we report a clinical and molecular investigation of Lafora disease segregating in a consanguineous Pakistani family. The proband presented with symptoms of rapidly progressive myoclonic epilepsy, but laboratory studies were negative for Lafora bodies and ragged red fibres. Sanger DNA sequencing of the genomic DNA of the proband for EPM2A and NHLRC1 identified a previously reported pathogenic nonsense variant in NHLRC1 (NM_198586.3:c.793C > T), which encodes the E3 ubiquitin ligase called malin. The NHLRC1 variant was found in a homozygous state in the proband, predicting a premature stop codon at position 265 (NP_940988.2:p.Arg265Ter). If the mRNA escaped nonsense-mediated decay, it would result in a truncated protein lacking 130 amino acids, including three NHL (NCL-1, HT2A, LIN-41) repeats.

Conclusions
Our study emphasizes the role of molecular genetic testing in patients presenting with symptoms of progressive myoclonic epilepsy.
Focus on the Forgotten Organelle: Regulation of Lysosomes in Skeletal Muscle
Authors: Moradi Neushaw , Kuznyetsova Anastasiya , Sanfrancesco Victoria C. , Champsi Sabrina , Hood David A. 
Published: January 2025

Abstract
Research on the role of the lysosome as the terminal organelle in autophagy and in communicating with other organelles in skeletal muscle is in its infancy. We hypothesize that the lysosome can adapt positively to exercise to improve the clearance of cargo, like dysfunctional mitochondria, within muscle, representing an important therapy for protein homeostasis in aging and muscle disuse.
Prevalence and clinical impact of the London classification: a prospective, international, multicenter study from the Lower Gastrointestinal International Consortium (LoGIC)
Authors: Vollebregt Paul F , Heitmann Paul T , Damon Henri , Garcia-Zermeño Karla , Garcia Fausto Daniel , Baker Jason , Schloithe Ann , Moshiree Baharak , Remes-Troche Jose M , Mion François , Dinning Phil G , Knowles Charles H , Scott S Mark 
Published: January 2025

Introduction:
The London classification provides standardization for characterization of disorders of anorectal function, although prevalences and clinical impact of these disorders are unclear.

Methods:
An international research consortium was established, including five specialist centers. Prospective data were collected in consecutive adults referred for refractory chronic constipation (CC), fecal incontinence (FI) or coexistent CC/FI over 18 months. Patients completed a standardized clinical questionnaire and underwent anorectal physiology tests which were performed and interpreted using uniform methodology. The prevalence of the London classification was compared between symptom groups (CC, FI and coexistent CC/FI), equipment types, and sites. Clinical impact was assessed using Cleveland Clinic constipation and St. Marks incontinence scores.

Results:
Of 1,012 included patients (85.6% women), 30.5% had self-reported CC, 33.2% had FI, and 36.3% had coexistent CC/FI. Rectoanal areflexia was uncommon (3.1%). Disorders of anal tone/contractility (CC: 45.0%; FI: 68.5%; coexistent CC/FI: 63.8%; p<0.0001), and disorders of rectal sensation (major findings: rectal hyposensitivity, CC: 10.0%; FI: 5.0%; coexistent CC/FI: 11.1%; p=0.018; rectal hypersensitivity, CC: 3.8%; FI: 9.0%; coexistent CC/FI: 4.9%; p=0.025) varied between symptom groups and were associated with symptom severity. Most disorders of rectoanal coordination were found in similar proportions across symptom groups and were not associated with severity of CC (median Cleveland Clinic constipation score 10-14 in all groups). Prevalences of some disorders differed between equipment types (specifically balloon expulsion test).

Discussion:
This prospective multicenter study provides information on the prevalence and clinical impact of the London classification, and will guide refinement of the current London classification.
Vision und Realität: Liaison Librarians und Informationskompetenz an der Universitäts- und Zentralbibliothek Zürich
Authors: Tschander Ladina , Sommaruga Andrea , Bernasconi Bettina 
Published: January 2025

Zusammenfassung
Die Gründung der Universitätsbibliothek Zürich warf die Frage auf, wie der Kontakt zu Forschenden, Lehrenden und Studierenden gestaltet werden soll, wenn das Bibliothekspersonal nicht mehr Teil der Institute ist. Die Nähe zur Akademie ist essenziell für die Vermittlung von Informationskompetenz. Zusammen mit der Zentralbibliothek Zürich wurde ein Alternativkonzept entwickelt. Seit 2022 arbeiten über 50 Liaison Librarians in diesem Bereich. Der Bericht untersucht die Zusammenarbeit und die erreichten Ergebnisse sowie die bestehenden Herausforderungen.
Metasurface-enhanced biomedical spectroscopy
Authors: Li Qiang , Yu Shiwang , Li Zhancheng , Liu Wenwei , Cheng Hua , Chen Shuqi 
Published: January 2025

Abstract
Enhancing the sensitivity of biomedical spectroscopy is crucial for advancing medical research and diagnostics. Metasurfaces have emerged as powerful platforms for enhancing the sensitivity of various biomedical spectral detection technologies. This capability arises from their unparalleled ability to improve interactions between light and matter through the localization and enhancement of light fields. In this article, we review representative approaches and recent advances in metasurface-enhanced biomedical spectroscopy. We provide a comprehensive discussion of various biomedical spectral detection technologies enhanced by metasurfaces, including infrared spectroscopy, Raman spectroscopy, fluorescence spectroscopy, and other spectral modalities. We demonstrate the advantages of metasurfaces in improving detection sensitivity, reducing detection limits, and achieving rapid biomolecule detection while discussing the challenges associated with the design, preparation, and stability of metasurfaces in biomedical detection procedures. Finally, we explore future development trends of metasurfaces for enhancing biological detection sensitivity and emphasize their wide-ranging applications.
Synthesizing sustainable construction paradigms: A comprehensive review and bibliometric analysis of granite waste powder utilization and moisture correction in concrete
Authors: Raman Sphurty , Nateriya Raman 
Published: January 2025

Abstract
This comprehensive review and scientometric analysis address the critical need for sustainable construction practices by examining the utilization of granite waste in concrete. The study responds to mounting environmental challenges in construction waste management, particularly addressing granite processing waste which comprises 50–60% of production [Indian Bureau of Mines. ariMinerals yearbook 2021 (Part-III: Mineral reviews), 60th edn, Granite (Advance Release), Indian Bureau of Mines, Ministry of Mines, Government of India, Nagpur, 2021.]. Through rigorous analysis of 585 publications from 2008 to 2024, the study reveals optimal granite waste replacement levels of 20–25% for sand and 10–15% for cement, yielding enhanced mechanical properties with compressive strengths up to 66 and 72 MPa, respectively. The research emphasizes the crucial role of moisture correction based on saturated surface dry conditions for consistent performance. Key findings demonstrate that granite waste can effectively replace up to 25% of sand and 15% of cement, contributing to reduced landfill use and lower CO2 emissions. The study identifies research gaps, including limited long-term durability studies and the need for standardization. Future directions propose investigating synergies with other supplementary cementitious materials and applications in emerging concrete technologies. This work provides a framework for optimizing granite waste in concrete, balancing environmental benefits with improved mechanical properties, and offering valuable insights for developing sustainable concrete solutions that potentially reduce environmental impact while enhancing performance.
„Mundi inversi“ Slávy dcery
Authors: Kiss Szemán Róbert 
Published: January 2025

Studie se zabývá strukturálními otázkami jednoho z nejvýznamnějších děl Jána Kollára, Slávy dcery (1824), které vyšlo před dvěma sty lety. Po prvním vydání básník dílo rozšířil o dva nové zpěvy (1832): Lethe provází čtenáře do slovanského nebe, Acheron vykresluje utrpení hříšníků ve slovanském pekle. Tyto písně sice zůstaly v genealogickém vztahu s původním dílem, ale jako nové, zvláštní textové formy zásadně změnily strukturu prvotní básnické skladby. Studie podrobuje kritice v české a slovenské literární historii obecně přijímaný estetický úsudek, dle kterého autor zmíněnými dvěma novými zpěvy „pokazil“ své původní dílo z r. 1824.Prostředníctvím recepční estetiky autor studie vychází z vědecké hypotézy, že Kollár, který ve 20. letech vytvořil básnickou skladbu Slávy dcera, ji na přelomu 30. let dekonstruoval a rozšířil. Nový textový konglomerát nejenom zásadně změnil rozsah původního básnického díla, ale otevřel také možnosti nové čtenářské interpretace na změněném recepčním horizontu třicátých a čtyřicátých let 19. století.Výskyt topoi souvisejících s alteritou není v Kollárově díle raritou: již dříve se autorovi podařilo identifikovat mimo jiné topos „fertilitas Pannoniae/Slaviae“ nebo „querela Hungariae/Slaviae“. V této studii se autor pokouší popsat dva nové zpěvy básnického díla pomocí pojmu „mundus inversus“, tedy literárního topoi „obráceného světa“ (Curtius, 1946). „Mundus inversus“ je kulturní topos známý z alterity, ke kterému sahali i autoři pozdějších období, včetně Kollára, s cílem představit kulturní a jazykové neřesti své doby, jakož i společenskou a politickou absurditu. Ke zobrazení převrácené společnosti použil Kollár bohatý vzorový materiál, v němž jsou většinou zastoupeni aktéři slovanských, německých a uherských dějin, církve a kultury. (Byly z nich vybrány ty nejtypičtější příklady, včetně sonetů představujících sv. Jeronýma jako „slovanského“ církevního otce, dále někteří emblematičtí němečtí historikové nebo maďarsko-srbský bilingvní básník Mihály Vitkovics.)Ukazuje se, že rozšíření Slávy dcery o dva zmíněné zpěvy slouží i k tematizaci nevýhodného postavení nastupujících novodobých slovanských národů v mocenských strukturách habsburské říše a Uherského království. V tomto pojetí sloužily karnevalizace (Bachtin) a literární topos „mundus inversus“ také jako kritika koloniálního systému 19. století, a přispěly tak k formování slovanského národního emblematismu.
SEEING AI COMO FERRAMENTA DE INCLUSÃO NA PÓS-GRADUAÇÃO: explorando benefícios e desafios na acessibilidade para alunos com deficiência visual
Authors: Brito Silvânia Rabelo , Chahini Thelma Helena Costa , Bottentuit Junior João Batista 
Published: January 2025

As Tecnologias Digitais de Informação e Comunicação (TIDC) têm promovido novas formas de interação e acesso ao conhecimento, criando várias oportunidades pedagógicas e facilitando a autonomia dos indivíduos. A tecnologia assistiva (TA), uma área interdisciplinar focada na identificação de recursos e serviços que melhoram a participação de pessoas com deficiência ou mobilidade reduzida, deve ser integrada à educação para maximizar seus benefícios. Este artigo de pesquisa visa demonstrar como o uso das tecnologias assistivas, especificamente o aplicativo Seeing AI da Microsoft, pode contribuir para auxiliar o acesso, permanência e atendimento educacional especializado para alunos com deficiência visual na pós-graduação. Utilizando uma abordagem descritiva, o estudo apresenta e analisa as funcionalidades do Seeing AI, discutindo suas aplicações no contexto acadêmico. Os principais resultados mostram que tal ferramenta pode facilitar a leitura de textos e a navegação em ambientes, oferecendo suporte prático aos alunos. No entanto, limitações relacionadas à precisão em ambientes acadêmicos e à necessidade de uma conexão de internet estável também são destacadas. As informações fornecidas podem servir como base para outras instituições que buscam implementar tecnologias assistivas, promovendo uma inclusão mais efetiva para estudantes com deficiência visual no contexto desafiador do ambiente acadêmico da pós-graduação.
Nanosilica Revolution: Unveiling the Impact on Enhancing Performance in Oil and Gas Well Cement
Authors: Montassir Mohamed , El-Mahallawi Iman , Salem Adel M. , Abdelhafiz Mostafa 
Published: January 2025

Summary
In recent times, numerous oil and gas wells have experienced diverse failures ranging from downhole plug malfunctions to compromised wellbore integrity, resulting in damage to aquifers, loss of assets, and posing significant economic and environmental hazards. The inclusion of nanosilica into oil and gas well cement emerges as a promising solution, demonstrating a positive influence on enhancing mechanical properties, such as compressive strength and durability. This study investigates the impact of nanosilica on the mechanical properties of Class G Portland cement slurry, aiming to enhance its application in the oil and gas industry. The influence of nanosilica on the cement compressive strength behavior of oilwell cementing systems directly set and cured under the condition of 110°C and 2,000 psi is studied. Test results indicate that the cement slurries containing 3% nanosilica experienced compressive strength enhancement by 40% compared with the base sample after 24 hours. The compressive strength test results are corroborated by further evidence from a permeability test as well as microstructure analysis of the set cement. The thermal stability of the set cement samples using thermogravimetry analysis (TGA) concludes that the sample containing 3% nanosilica has the lowest mass loss. Future research should focus on long-term durability studies and comprehensive mechanical property assessments to further validate the benefits of these nanomaterials in real-world conditions.
Determinants of foreign direct investment in the Middle East and North Africa region: evidence from balanced panel data analysis
Authors: Nazzal Ahmed , Rebull María-Victoria Sánchez , Niñerola Angels Monserrat 
Published: January 2025

Abstract

Purpose: this study investigates factors influencing foreign direct investment (FDI) inflows to the Middle East and North Africa (MENA) region.
Approach/design: using a balanced Panel data from 24 MENA economies covering 1980-2022 we employ econometric techniques (unit root, cointegration, FMOLS, DOLS, AMG, CCEMG) to evaluate the impacts of market and resource-seeking motives, institutional, government policies (macroeconomic level), and political risk on FDI inflows into MENA region.
Findings: The long-term results suggest that market size, low corruption, government effectiveness and exchange rate contribute to FDI inflows while natural resources availability, role of law and voice and accountability deters FDI inflows to MENA. Contrary, political stability and regulatory quality factors has no significant effects on FDI inflows.
Originality/Value: the study has potential implications for boosting FDI inflows into MENA region MENA such as: Policymakers of MENA economies should adopt stable monetary policies, implement policies and regulations to Promote private sector development, improve institutional quality and maintain macroeconomic stability. Diversification of economies and reduction of reliance on natural resources are essential for long-term FDI attraction. Additionally, green innovation should be encouraged by spending more on R&D, green technology and improving policies regarding the rule of law to create a good investment environment.
Future Research: Further research is needed to explore the specific mechanisms through which these factors influence FDI inflows and to assess the potential impact of other variables, such as technological advancements and regional integration.
Extended distribution of Lycianthes biflora (Lour.) Bitter (Solanaceae) in Eastern Ghats, India
Authors: Sahu Sudam C. , Priyadarshini Sifan , Tudu Sabita , Jena Jeevan K. , Gogineni Prakash C. , Dash Sudhansu Sekhar 
Published: January 2025

Abstract

Lycianthes biflora (Lour.) Bitter, hitherto known only from northeastern India, is now reported for the first time from the Eastern Ghats based on a collection from the Similipal Biosphere Reserve of Odisha. The present report confirms the range extension of this species further to Eastern Ghats from northeastern region of the country. A detailed taxonomic description, ecology, phenology, distribution, field and dissected floral parts and T.S. of immature fruit photographs were provided for easy identification.