bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Going global’ and pollution in home country: Evidence from Chinese industrial firms
Authors: Lin Xi , He Ling‐Yun 
Published: April 2023

AbstractThe relationship between international investment and the environment is always concerned around the world, but the literature mainly focuses on the impact of foreign direct investment (FDI) (especially from developed countries to developing countries). Currently, many developing countries have regarded outward foreign direct investment (OFDI) as a critical task of economic development and encourage firms to ‘Going global’. After OFDI, how do firms' pollution emissions change? In this study, we employ the data of Chinese industrial firms to empirically answer this question. In particular, we combine inverse probability weighted matching with a difference‐in‐difference approach to identify the causal effect of OFDI on firm‐level pollution emissions. Our result indicates that OFDI leads to the reduction in both emission intensity and emission levels. This pollution reduction is driven by improving abatement technology and decreasing energy intensity. It potentially implies that OFDI reduces pollution emissions mainly through the ‘reverse technology spillover’ effect rather than ‘pollution transfer’ effect. In addition, pollution reductions caused by OFDI are prominent for local production OFDI and resource exploitation OFDI, OFDI to high‐income countries as well as capital‐intensive industries. Overall, this study not only provides an initial evidence for the relationship between OFDI and the environment at the firm level but also provides enlightenments for international investment and sustainable development.
Long‐term outcome in patients with mantle cell lymphoma following high‐dose therapy and autologous stem cell transplantation
Authors: Metzner Bernd , Müller Thomas H. , Casper Jochen , Kimmich Christoph , Köhne Claus‐Henning , Petershofen Eduard , Renzelmann Andrea , Thole Ruth , Voss Andreas , Dreyling Martin , Hoster Eva , Klapper Wolfram , Pott Christiane 
Published: April 2023

AbstractBackgroundLong‐term clinical and molecular remissions in patients with mantle cell lymphoma (MCL) after autologous stem cell transplantation (ASCT) have been evaluated in only a few studies.Design and MethodsSixty‐five patients with MCL received ASCT (54 first‐line ASCT, 10 second‐line ASCT, and 1 third‐line ASCT). In the case of long‐term remission (≥5 years; n = 27), peripheral blood was tested for minimal residual disease (MRD) by t(11;14)‐ and IGH‐PCR at the last follow‐up.ResultsTen‐year overall survival (OS), progression‐free survival (PFS), and freedom from progression (FFP) after first‐line ASCT were 64%, 52%, and 59% versus after second‐line ASCT 50%, 20%, and 20%, respectively. Five‐year OS, PFS, and FFP for the first‐line cohort were 79%, 63%, and 69%, respectively. Five‐year OS, PFS, and FFP after second‐line ASCT were 60%, 30%, and 30%, respectively. Treatment‐related mortality (3 months after ASCT) was 1.5%. So far 26 patients developed sustained long‐term clinical and molecular complete remissions of up to 19 years following ASCT in first treatment line.ConclusionSustained long‐term clinical and molecular remissions are achievable following ASCT.
Cytokine profile of the epidermis is region specific and may determine the characteristics of inflammation
Authors: Szabó Lilla , Dajnoki Zsolt , Somogyi Orsolya , Gáspár Krisztián , Hendrik Zoltán , Szabó Imre Lőrinc , Szöllősi Attila Gábor , Dinya Tamás , Törőcsik Dániel , Kapitány Anikó , Szegedi Andrea 
Published: April 2023

AbstractRecent data indicate that distinct skin areas show different microbial/chemical milieu. Keratinocytes (KC) respond to these stimuli by producing cytokine mediators. Therefore, we aimed to determine KC‐derived cytokine expression in distinct healthy skin regions (gland‐poor [GP], sebaceous gland‐rich [SGR] and apocrine gland‐rich [AGR]), and their changes in skin diseases of the given regions (atopic dermatitis [AD], papulopustular rosacea [PPR] and psoriasis). Cytokines were analysed at the mRNA and protein levels, and literature analysis was performed for functional categorization. The three regions showed characteristically different cytokine patterns. GP was featured by an IL‐25/IL‐33/IL‐36RA/IL‐38/IL‐18 cytokine milieu, SGR was characterized by IL‐23/IL‐17C/IL‐18, and AGR skin exhibited a mixed IL‐25/IL‐33/IL‐23/IL‐18 profile. Literature analyses revealed different homeostatic and proinflammatory roles of these cytokine patterns (Th2 related in GP, Th17 related in SGR and mixed Th2/Th17 in AGR). In skin diseases which are primarily epidermal cytokine‐driven (AD, PPR), the level of the regionally characteristic cytokines were further elevated, in contrast to the autoantigen‐driven psoriasis, where the cytokine pattern was independent from the localization. Healthy skin regions are equipped with different KC‐derived cytokine profiles, which may influence each region's capability of mediator production in certain types of dermatoses.
Review of audio deepfake detection techniques: Issues and prospects
Authors: Dixit Abhishek , Kaur Nirmal , Kingra Staffy 
Published: April 2023

AbstractIn the past years, multimedia content has improved in realism and plausibility owing to the development of deep learning techniques, particularly the generative adversarial networks and variational auto‐encoders. Though digital content, especially digital movies shot from a certain viewpoint gives a true representation of reality, yet the ubiquitous usage of content manipulation techniques casts doubt on its veracity. Deepfaking an AI based tampering technique, is able to map facial and acoustic features of a source person onto the target with an intention to make target say or enact the things that has not happened in real. Numerous approaches have been proposed in the literature for detection of image and video deepfakes. With technological advancement, researchers have also started to examine audio deepfakes and ways to detect them. As there is currently no comprehensive overview of audio deepfake generation and detection techniques, this paper aims to provide a survey of the relevant literature in this area. This survey paper intends to help research fraternity about the available audio generation and detection approaches for design of reliable detection models in future to classify fake and real audios.
Traces in the shadow: Occupational outcomes of previously undocumented migrants in Italy
Authors: Molinari Rocco , Impicciatore Roberto , Ortensi Livia Elisa 
Published: April 2023

AbstractUsing a representative sample of currently legal third‐country immigrants in Italy, obtained from the Social Condition and Integration of Foreign Citizens survey, this article examines the long‐term labour market consequences of previous undocumented spells. First, formerly undocumented immigrants are identified using retrospective information on respondents' legal status. Second, immigrants are classified according to the duration of irregular spells before the achievement of the first residence permit. Third, current labour market outcomes are investigated to account for the endogeneity underlying the previous undocumented history. Results show that even though formerly undocumented immigrants are more likely to participate in the labour market, they are more likely to be employed in underqualified occupations than continuously legal immigrants. The duration of the irregular experience affects occupational qualification negatively, among both men and women. The lack of legal entry channels and policies to plan and regulate migration to Italy may reinforce labour market segmentation, exposing migrants to long‐term occupational downgrade.
Executive summary of consensus clinical practice guidelines for the prevention of infection in patients with multiple myeloma
Authors: Teh Benjamin W. , Reynolds Gemma , Slavin Monica A. , Cooley Louise , Roberts Matthew , Liu Eunice , Thursky Karin , Talaulikar Dipti , Mollee Peter , Szabo Ferenc , Ward Chris , Chan Henry , Prince H. Miles , Harrison Simon J. ,   the Medical and Scientific Advisory Group Myeloma Australia and National Centre for Infections in Cancer
Published: April 2023

AbstractInfection remains a significant contributor to morbidity and mortality in patients with myeloma. This guideline was developed by a multidisciplinary group of clinicians who specialise in the management of patients with myeloma and infection from the medical and scientific advisory group from Myeloma Australia and the National Centre for Infections in Cancer. In addition to summarising the current epidemiology and risk factors for infection in patients with myeloma, this guideline provides recommendations that address three key areas in the prevention of infection: screening for latent infection, use of antimicrobial prophylaxis and immunoglobulin replacement and vaccination against leading respiratory infections (severe acute respiratory syndrome coronavirus 2, influenza and Streptococcus pneumoniae) and other preventable infections. This guideline provides a practical approach to the prevention of infection in patients with myeloma and harmonises the clinical approach to screening for infection, use of prophylaxis and vaccination to prevent infectious complications.
Informing a value care model: lessons from an integrated adult neurogenomics clinic
Authors: McLean Alison , Tchan Michel , Devery Sophie , Smyth Renee , Shrestha Rupendra , Kumar Kishore R. , Tomlinson Susan , Tisch Stephen , Wu Kathy H. C. 
Published: April 2023

AbstractBackgroundAdvances in genomics provide improved opportunities for diagnosis of complex neurogenetic disorders, yet the optimal approach to translate these benefits to the outpatient clinic is unclear.AimsWe retrospectively reviewed referral indications and outcomes of an integrated multidisciplinary team (MDT) clinic pathway for adults with suspected neurogenetic disorders. The associated cost implications were estimated.MethodsConsecutive patients who attended the neurogenomics clinic from January 2017 to April 2020 were included. The clinic comprised neurologists, clinical geneticists and genetic counsellors, who assessed each patient concurrently.ResultsNinety‐nine new patients were referred spanning 45 different clinical diagnoses. Following MDT clinical assessment, 23% (23/99) of referral diagnoses were revised prior to molecular testing. Eighty‐one patients (82%) underwent genetic testing, including 43 exome‐based panels, 15 whole‐genome sequencing, 14 single gene tests, 27 repeat‐primed polymerase chain reaction testing and two chromosomal microarrays. Overall, 33/99 patients (33%) received a diagnosis, either a molecular diagnosis (n = 24, of which 22 were diagnostic and two were predictive) or a clinical diagnosis (n = 9). Of the clinical diagnosis cohort, five patients received a diagnosis without molecular testing and four patients whose negative testing (one diagnostic and three predictive) allowed exclusion of genetic differentials and, hence, confirmation of clinical diagnoses. The diagnostic rate following MDT and diagnostic testing was 30% (28/94), excluding the five predictive testing cases. MDT assessment aligned with eventual molecular diagnoses in 96% of cases. The estimated average costs were AU$1386 per patient undergoing MDT assessment and AU$4159 per diagnosis achieved.ConclusionsWe present an integrated multidisciplinary neurogenomics clinic pathway providing a diagnostic yield of 33% (30% excluding predictive testing cases), with costing implications. The relatively high diagnostic yield may be attributed to multidisciplinary input integrating accurate phenotyping of complex disorders and interpretation of genomic findings.
The epidemiological pattern of seasonal influenza in four sentinel sites in Iraq
Authors: Radhi Ahmed Hasan , Ibrahim Ziyad Hazim , Alhilifi Riyadh 
Published: April 2023

AbstractIntroductionInfluenza is an acute viral infection with significant morbidity and mortality. It occurs annually each winter, which is called seasonal influenza, and is preventable through safe vaccine.AimThe aim of this work is to know the epidemiological pattern of patients with seasonal influenza in Iraqi sentinel sites.MethodsA cross‐sectional study was carried out on records of patients who attended four sentinel sites and registered to have influenza‐like illness (ILI) or severe acute respiratory infection (SARI), and laboratory investigated.ResultsThe total number of cases was 1124; 36.2% of them aged 19–39 years; 53.9% were female; 74.9% lived in urban areas; 64.3% diagnosed as ILI; and 35.7% as SARI; 15.9% had diabetes, 12.7% had heart disease, 4.8% had asthma, 3% had a chronic lung disease, and 2% had hematological disease; 94.6% did not get influenza vaccine. About COVID‐19 vaccine, 69.4% were not vaccinated, 3.5% got only one dose, and 27.1% completed two doses. Only the SARI cases needed admission; among them, 95.7% were cured. 6.5% were diagnosed with influenza‐A virus, 26.1% had COVID‐19, and 67.5% were negative. Among those with influenza, 97.3% had H3N2 subtype and 2.7% had H1N1 pdm09.ConclusionsThe percentage of influenza virus in Iraq is relatively small. The age, classification of case (ILI or SARI), having diabetes, heart disease, or immunological disease, and taking COVID‐19 vaccine have a significant association with influenza.RecommendationsIt is needed for similar sentinel sites in other health directorates and for rising health education about seasonal influenza and its vaccine.
Linagliptin ameliorated cardiac fibrosis and restored cardiomyocyte structure in diabetic mice associated with the suppression of necroptosis
Authors: Adhikari Juthi , Hirai Taro , Kawakita Emi , Iwai Kunimitsu , Koya Daisuke , Kanasaki Keizo 
Published: April 2023

ABSTRACTAims/IntroductionLinagliptin is a selective dipeptidyl peptidase (DPP)‐4 inhibitor capable of successfully regulating blood glucose levels. The cardiovascular protective effects of several DPP‐4 inhibitors have been shown in preclinical studies; however, the detailed influence of DPP‐4 inhibitors on diabetic pathological alterations in cardiac tissue has not yet been elucidated.Materials and MethodsWe combined laboratory‐based experiments and bioinformatics techniques to identify suitable candidate targets with significant biological pathways. Mice with streptozotocin‐induced insulin deficiency diabetic model were utilized for in vivo experiments. Mice were euthanized at 24 weeks after the induction of diabetes; linagliptin intervention was carried out for 4 weeks before euthanasia. Microarray analysis of heart samples was carried out.ResultsMice with streptozotocin‐induced diabetes, but not control mice, showed cardiac fibrosis with an endothelial–mesenchymal transition program, and myocardial fiber and sarcomere disruption; linagliptin alleviated these diabetes‐associated pathological alterations without altering blood glucose levels. Bioinformatics analysis utilizing a microarray dataset identified 10 hub genes that were confirmed to have human disease relevance by Gene Expression Omnibus analysis. Among these hub genes, we focused on the Sox9–necroptosis axis as a therapeutic target in diabetic hearts. Indeed, diabetic mice showed the induction of necroptosis‐associated genes and the phosphorylation of RIP3 and mixed lineage kinase domain‐like protein.ConclusionsLinagliptin showed excellent heart protection in mice with streptozotocin‐induced diabetes associated with alterations in human disease‐relevant hub genes. Further investigation is required to determine why DPP‐4 inhibitors do not show similar superior organ‐protective effects in the clinical setting.
What came first, the shark or the egg? Discovery of a new species of deepwater shark by investigation of egg case morphology
Authors: White William T. , O'Neill Helen L. , Devloo‐Delva Floriaan , Nakaya Kazuhiro , Iglésias Samuel P. 
Published: April 2023

AbstractApristurus ovicorrugatus, a new species of deepwater catshark, is described from northwestern Australia. Unique egg cases belonging to an unknown species of Apristurus prompted a more detailed investigation of Apristurus specimens off northwestern Australia. One specimen previously identified as A. sinensis collected off Dampier Archipelago was found gravid with a single egg case. Removal of this egg case confirmed that this species was responsible for producing the unique egg cases previously recorded. The egg cases of this species have strong T‐shaped longitudinal ridges on the dorsal and ventral surfaces which are unique in the genus Apristurus. The ridges most closely resemble those present in Bythaelurus canescens from South America, but are larger and always T‐shaped. The holotype is closest morphologically to A. sinensis but differs in having a medium brown buccal cavity (vs. jet black), ridged egg cases (vs. smooth egg cases), fewer intestinal spiral valve turns and larger pectoral fins. The holotype is also similar, and closest on a molecular level, to A. nakayai with which it shares a unique synapomorphic character, the white shiny iris (apomorphic within the genus). A late‐term embryo removed from an egg case superficially resembled the holotype except in having two parallel rows of enlarged dermal denticles on the dorsolateral predorsal surface. Recent nomenclatural changes to the genera Apristurus and Pentanchus are discussed and challenged. This study highlights the important contribution that egg case morphology has on oviparous elasmobranch taxonomy.
Curricular Quality Improvement in Midwifery: Simulating Unexpected Perinatal Loss
Authors: Altman Susan D. , Tilley Charles P. , Feldman Rebecca , Brennan Mary , Wholihan Dorothy 
Published: April 2023

IntroductionCaring for families experiencing perinatal loss is a fundamental component of midwifery practice, but little attention is paid to perinatal palliative care in midwifery curricula. Lack of educational preparation and self‐care resources negatively impacts midwifery students and health care teams caring for families experiencing stillbirth.ProcessA private, urban university conducted a curricular quality improvement project to integrate perinatal palliative care into the midwifery curriculum using a high‐fidelity, branching simulation pedagogy. Simulation objectives were developed from curricular gap analyses and the Core Competencies for Basic Midwifery Practice. Development of the Unexpected Perinatal Loss Simulation was guided by the International Nursing Association for Clinical Simulation and Learning Outcomes and Objectives and Design Standards. The Unexpected Perinatal Loss Simulation was revised based on qualitative data from student focus groups and expert content validation.OutcomesQualitative data yielded 4 key domains: presimulation, simulation skills, prior experience/personal reflections, and recommendations. Simulation procedures and scenario content were revised, after which 8 expert clinicians in the fields of midwifery, palliative care, and psychiatry validated the scenario content using the Lynn method. Two items did not meet the content validity index (CVI) threshold of 0.78, necessitating review by stakeholders; however, the overall scenario CVI threshold was met (0.82).DiscussionThrough this project, faculty integrated perinatal palliative care into the midwifery program using a novel approach of high‐fidelity, branching simulation, structured debriefing, and an introductory self‐care skills workshop. Potential clinical impact includes skillful perinatal palliative care with effective communication skills to mitigate how families experience and remember a traumatic loss and facilitate the grieving process. Students voiced insights into how they would process loss and seek support to mitigate their own grief as future midwives.
Can Security Design Foster Household Risk‐Taking?
Authors: CALVET LAURENT E. , CELERIER CLAIRE , SODINI PAOLO , VALLEE BORIS 
Published: April 2023

ABSTRACTThis paper shows that securities with nonlinear payoff designs can foster household risk‐taking. We demonstrate this effect by exploiting the introduction of capital guarantee products in Sweden between 2002 and 2007. Their fast and broad adoption is associated with an increase in expected financial portfolio returns. The effect is especially strong for households with low‐risk appetite ex ante. These empirical facts are consistent with a life‐cycle model in which households have pessimistic beliefs or preferences combining loss aversion and narrow framing. Our results illustrate how security design can mitigate behavioral biases to increase mean household portfolio returns.
Development of University of Tokyo's eating disorders inventory in female athletes
Authors: Chiba Yoko , Nose‐Ogura Sayaka , Sekiguchi Kuniko , Eda Kaori , Nakamura Hiroe , Koshimizu Takako , Yamamoto Hiroaki , Yamaguchi Tatsuya , Harada Miyuki , Wada‐Hiraike Osamu , Osuga Yutaka 
Published: April 2023

AbstractAimsThis study aimed to develop a scale to screen for eating disorders in female athletes.MethodsPreliminary survey: A total of 275 female athletes (mean age: 19.4 ± 1.0 years) and 7 female athletes diagnosed with eating disorders (mean age: 20.1 ± 2.5 years) were administered screening items prepared based on an existing scale, followed by exploratory factor analysis.Main survey: Six items, relating to three factors, were extracted, and 201 female athletes (mean age: 22.3 ± 4.8 years) and 6 female athletes diagnosed with current or a history of eating disorders (mean age: 18.8 ± 2.9 years) were queried. The diagnostic validity of the scale was then evaluated.ResultsPreliminary survey: Questions (α = 0.71) were extracted from six items, relating to three factors, and collectively termed the University of Tokyo's eating disorders inventory in female athletes (TEDIFA). To determine the scale cut‐off score, ROC analysis was performed with the total score, and the cut‐off and gray zone scores were set at 13 and 11, respectively.Main survey: At the cut‐off score of 13, AUC, sensitivity, and specificity were 0.83 (p < 0.05), 75%, and 90%, respectively.ConclusionsThe scale that was developed, TEDIFA, consisted of six items. The cut‐off scores were set at 11 for the gray zone (sensitivity: 75%; specificity: 56%; accurate diagnosis rate: 60%), and 13 for positivity (sensitivity: 75%; specificity: 90%; accurate diagnosis rate: 87%), demonstrating the reliability and validity of the scale.