bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of adenoma recurrence after endoscopic mucosal resection
Authors: Tate David J , Desomer Lobke , Argenziano Maria Eva , Mahajan Neha , Sidhu Mayenaaz , Vosko Sergei , Shahidi Neal , Lee Eric , Williams Stephen J , Burgess Nicholas G , Bourke Michael J 
Published: July 2023

ObjectiveResidual or recurrent adenoma (RRA) after endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps (LNPCPs) of ≥20 mm is a major limitation. Data on outcomes of the endoscopic treatment of recurrence are scarce, and no evidence-based standard exists. We investigated the efficacy of endoscopic retreatment over time in a large prospective cohort.DesignOver 139 months, detailed morphological and histological data on consecutive RRA detected after EMR for single LNPCPs at one tertiary endoscopy centre were prospectively recorded during structured surveillance colonoscopy. Endoscopic retreatment was performed on cases with evidence of RRA and was performed predominantly using hot snare resection, cold avulsion forceps with adjuvant snare tip soft coagulation or a combination of the two.Results213 (14.6%) patients had RRA (168 (78.9%) at first surveillance and 45 (21.1%) thereafter). RRA was commonly 2.5–5.0 mm (48.0%) and unifocal (78.7%). Of 202 (94.8%) cases which had macroscopic evidence of RRA, 194 (96.0%) underwent successful endoscopic therapy and 161 (83.4%) had a subsequent follow-up colonoscopy. Of the latter, endoscopic therapy of recurrence was successful in 149 (92.5%) of 161 in the per-protocol analysis, and 149 (73.8%) of 202 in the intention-to-treat analysis, with a mean of 1.15 (SD 0.36) retreatment sessions. No adverse events were directly attributable to endoscopic therapy. Further RRA after endoscopic therapy was endoscopically treatable in most cases. Overall, only 9 (4.2%, 95% CI 2.2% to 7.8%) of 213 patients with RRA required surgery.Thus 159 (98.8%, 95% CI 95.1% to 99.8%) of 161 cases with initially successful endoscopic treatment of RRA and follow-up remained surgery-free for a median of 13 months (IQR 25.0) of follow-up.ConclusionsRRA after EMR of LNPCPs can be effectively treated using simple endoscopic techniques with long-term adenoma remission of >90%; only 16% required retreatment. Therefore, more technically complex, morbid and resource-intensive endoscopic or surgical techniques are required only in selected cases.Trial registration numbersNCT01368289andNCT02000141
Low-intensity daily smoking and mortality risk among Mexican women
Authors: Gutiérrez-Torres Daniela Sarahí , Brochier Marion , Stern Dalia , Cortés-Valencia Adrian , Hernández-Ávila Juan Eugenio , Morales-Carmona Evangelina , Barrientos-Gutierrez Tonatiuh , Inoue-Choi Maki , Lajous Martin , Freedman Neal D 
Published: July 2023

Objective
To examine the association between low-intensity smoking (10 or less cigarettes per day) and all-cause and cause-specific mortality risk among women who smoke and by age at cessation among women who previously smoked.

Methods
In this study, 104 717 female participants of the Mexican Teachers’ Cohort Study were categorised according to self-reported smoking status at baseline (2006/2008) and were followed for mortality through 2019. We estimated HRs and 95% CIs for all-cause and cause-specific mortality using multivariable Cox proportional hazards regression models with age as the underlying time metric.

Results
Smoking as few as one to two cigarettes per day was associated with higher mortality risk for all causes (HR: 1.36; 95% CI 1.10 to 1.67) and all cancers (HR: 1.46; 95% CI 1.05 to 2.02), compared with never smoking. Similarly, slightly higher HRs were observed among participants smoking ≥3 cigarettes per day (all causes HR: 1.43; 95% CI 1.19 to 1.70; all cancers HR: 1.48; 95% CI 1.10 to 1.97; cardiovascular disease HR: 1.58; 95% CI 1.09 to 2.28).

Conclusions
In this large study of Mexican women, low-intensity smoking was associated with higher mortality risk for all causes and all cancers. Interventions are needed to promote cessation among women who smoke at low-intensity in Mexico, regardless of how few cigarettes they smoke per day.
A black hole toy model with non-local and boundary modes from non-trivial boundary conditions
Authors: Cheng Peng 
Published: July 2023

AbstractWe study gauge theories between two parallel boundaries with non-trivial boundary conditions, which serve as a toy model for black hole background with two boundaries near the horizon and infinite, aiming for a better understanding of the Bekenstein–Hawking entropy. The new set of boundary conditions allows boundary modes and non-local modes that interplay between the two boundaries. Those boundary modes and Wilson lines stretched between the two boundaries are carefully analyzed and are confirmed as physical variables in the phase space. Along with bulk fluctuation modes and topological modes, the partition function and entropy of all physical modes are evaluated via Euclidean path integral. It is shown that there are transitions between the dominance of different modes as we vary the temperature. The boundary fluctuation modes whose entropy is proportional to the volume dominate at high temperatures, and the boundary-area scaled boundary modes and Wilson lines are the more important at low temperatures. At super-low temperatures, when all the fluctuation modes die off, we see the topological modes whose entropy is the logarithm of the length scales of the system. The boundary modes and non-local modes should have their counterparts in a black hole system with similar boundary conditions, which might provide important hints for black hole physics.
Quasiperiodic oscillations around hairy black holes in Horndeski gravity
Authors: Rayimbaev Javlon , Dialektopoulos Konstantinos F. , Sarikulov Furkat , Abdujabbarov Ahmadjon 
Published: July 2023

AbstractTesting gravity theories and their parameters using observations is an important issue in relativistic astrophysics. In this context, we investigate the motion of test particles and their harmonic oscillations in the spacetime of non-rotating hairy black holes (BHs) in Hordeski gravity, together with astrophysical applications of quasiperiodic oscillations (QPOs). We show possible values of upper and lower frequencies of twin-peak QPOs which may occur in the orbits from innermost stable circular orbits to infinity for various values of the Horndeski parameter q in relativistic precession, warped disk models, and three different sub-models of the epicyclic resonant model. We also study the behaviour of the QPO orbits and their position relative to innermost stable circular orbits (ISCOs) with respect to different values of the parameter q. It is obtained that at a critical value of the Horndeski parameter ISCO radius takes 6M which has been in the pure Schwarzschild case. Finally, we obtain mass constraints of the central BH of microquasars GRS 1915+105 and XTE 1550-564 at the GR limit and the possible value of the Horndeski parameter in the frame of the above-mentioned QPO models. The analysis of orbits of twin peak QPOs with the ratio of upper and lower frequencies 3:2, around the BHs in the frame of relativistic precession (RP) and epicyclic resonance (ER4) QPO models have shown that the orbits locate close to the ISCO. It is obtained that the distance between QPO orbits and ISCO is less than the error of the observations.
A spatially constrained QCD colour reconnection in $$\textrm{pp}$$, $$\textrm{p}A$$, and $$AA$$ collisions in the Pythia8/Angantyr model
Authors: Lönnblad Leif , Shah Harsh 
Published: July 2023

AbstractWe present an updated version of the QCD-based colour reconnection model in Pythia8, where we constrain the range in impact parameter for which reconnections are allowed. In this way, we can introduce more realistic colour reconnections in the Angantyr model for heavy ion collisions, where previously only reconnections within separate nucleon sub-collisions have been allowed. We investigate how the new impact parameter constraint influences final states in $$\textrm{pp}$$
pp
collisions, and retune parameters of the multi-parton interaction parameters in Pythia to compensate so that minimum bias data are reproduced. We also study multiplicity distributions in $$\textrm{p}A$$

p
A

collisions and find that, in order to counteract the loss in multiplicity due to the introduction of global colour reconnections, we need to modify some parameters in the Angantyr model while keeping the parameters tuned to $$\textrm{pp}$$
pp
fixed. With Angantyr we can then extrapolate to $$AA$$

AA

collisions without further parameter tuning and retaining a reasonable description of the basic multiplicity distributions.
Integrated Multi-omics Analysis of Early Lung Adenocarcinoma Links Tumor Biological Features with Predicted Indolence or Aggressiveness
Authors: Senosain Maria-Fernanda , Zou Yong , Patel Khushbu , Zhao Shilin , Coullomb Alexis , Rowe Dianna J. , Lehman Jonathan M. , Irish Jonathan M. , Maldonado Fabien , Kammer Michael N. , Pancaldi Vera , Lopez Carlos F. 
Published: July 2023

Lung adenocarcinoma (LUAD) is a heterogeneous group of tumors associated with different survival rates, even when detected at an early stage. Here, we aim to investigate the biological determinants of early LUAD indolence or aggressiveness using radiomics as a surrogate of behavior. We present a set of 92 patients with LUAD with data collected across different methodologies. Patients were risk-stratified using the CT-based Score Indicative of Lung cancer Aggression (SILA) tool (0 = least aggressive, 1 = most aggressive). We grouped the patients as indolent (x ≤ 0.4, n = 14), intermediate (0.4 &gt; x ≤ 0.6, n = 27), and aggressive (0.6 &gt; x ≤ 1, n = 52). Using Cytometry by time of flight (CyTOF), we identified subpopulations with high HLA-DR expression that were associated with indolent behavior. In the RNA sequencing (RNA-seq) dataset, pathways related to immune response were associated with indolent behavior, while pathways associated with cell cycle and proliferation were associated with aggressive behavior. We extracted quantitative radiomics features from the CT scans of the patients. Integrating these datasets, we identified four feature signatures and four patient clusters that were associated with survival. Using single-cell RNA-seq, we found that indolent tumors had significantly more T cells and less B cells than aggressive tumors, and that the latter had a higher abundance of regulatory T cells and Th cells. In conclusion, we were able to uncover a correspondence between radiomics and tumor biology, which could improve the discrimination between indolent and aggressive LUAD tumors, enhance our knowledge in the biology of these tumors, and offer novel and personalized avenues for intervention.Significance:This study provides a comprehensive profiling of LUAD indolence and aggressiveness at the biological bulk and single-cell levels, as well as at the clinical and radiomics levels. This hypothesis generating study uncovers several potential future research avenues. It also highlights the importance and power of data integration to improve our systemic understanding of LUAD and to help reduce the gap between basic science research and clinical practice.
Proteogenomic Approaches for the Identification of NF1/Neurofibromin-depleted Estrogen Receptor–positive Breast Cancers for Targeted Treatment
Authors: Kim Beom-Jun , Zheng Ze-Yi , Lei Jonathan T. , Holt Matthew V. , Chen Anran , Peng Jianheng , Fandino Diana , Singh Purba , Kennedy Hilda , Dou Yongchao , Chica-Parrado María del Rosario , Bikorimana Emmanuel , Ye Dan , Wang Yunguan , Hanker Ariella B. , Mohamed Nada , Hilsenbeck Susan G. , Lim Bora , Asirvatham Jaya Ruth , Sreekumar Arun , Zhang Bing , Miles George , Anurag Meenakshi , Ellis Matthew J. , Chang Eric C. 
Published: July 2023

NF1 is a key tumor suppressor that represses both RAS and estrogen receptor-α (ER) signaling in breast cancer. Blocking both pathways by fulvestrant (F), a selective ER degrader, together with binimetinib (B), a MEK inhibitor, promotes tumor regression in NF1-depleted ER+ models. We aimed to establish approaches to determine how NF1 protein levels impact B+F treatment response to improve our ability to identify B+F sensitive tumors. We examined a panel of ER+ patient-derived xenograft (PDX) models by DNA and mRNA sequencing and found that more than half of these models carried an NF1 shallow deletion and generally have low mRNA levels. Consistent with RAS and ER activation, RET and MEK levels in NF1-depleted tumors were elevated when profiled by mass spectrometry (MS) after kinase inhibitor bead pulldown. MS showed that NF1 can also directly and selectively bind to palbociclib-conjugated beads, aiding quantification. An IHC assay was also established to measure NF1, but the MS-based approach was more quantitative. Combined IHC and MS analysis defined a threshold of NF1 protein loss in ER+ breast PDX, below which tumors regressed upon treatment with B+F. These results suggest that we now have a MS-verified NF1 IHC assay that can be used for patient selection as a complement to somatic genomic analysis.

Significance:
A major challenge for targeting the consequence of tumor suppressor disruption is the accurate assessment of protein functional inactivation. NF1 can repress both RAS and ER signaling, and a ComboMATCH trial is underway to treat the patients with binimetinib and fulvestrant. Herein we report a MS-verified NF1 IHC assay that can determine a threshold for NF1 loss to predict treatment response. These approaches may be used to identify and expand the eligible patient population.
The Design Problem Revisited
Authors: Lutfi Dina 
Published: July 2023

Abstract
The terms “problem and solution” are omnipresent the world over in various design disciplines and designers often position themselves as problem solvers. Through a rigorous exploration of different perspectives on the problem-solution model and its impact, this article revisits how designers define, perceive, and consequently practice design. It closely explores how frequently propagated terminology and perceptions can impact designers and their work—educationally and professionally. The article also presents alternative approaches to thinking about and practicing design.
Mediating Interpersonal Synchronization in Children through a Full-Body Mixed Reality System: Analysis of the Pre-Interactive Mandala Experience
Authors: Gali Olga , Ercan Sena Beste , Atherton Gray , Cross Liam , Sayis Batuhan , Heaton Pamela , Pares Narcis 
Published: July 2023

Abstract
Interpersonal entrainment (IPE), motor synchronization to a common rhythm, can be used to strengthen the ability to communicate and coordinate actions between citizens. Different studies show how children's and adults’ behaviors changed positively by increasing their cooperation, helpfulness, and affiliation levels after performing activities in synchrony. However, those activities are often affected by the mediation of a researcher. This problem can be addressed by using new technologies such as mixed reality (MR) full-body systems. The aim of this study was to develop a playful MR pre-interactive (noninteractive visual/auditory cues) experience, the Mandala, to promote IPE. Sixty-six children were presented, in groups of four, with one of the conditions: async movements and ambient music (control) or sync movements accompanied by rhythmic (experimental 1) or ambient music (experimental 2). We analyzed the children's ability to follow the visual elements well (temporal pattern and precision), the good use of the interactive object, and their level of synchrony. The results show how the children followed the visual pattern well and accurately, used the interactive object as proposed, and achieved high levels of synchrony. We provided initial insights on how full-body MR systems can be used to promote IPE without an external facilitator.
Analyse linguistique d’un corpus épistolaire en moyen arabe
Authors: Guerrero Jairo 
Published: July 2023

Résumé
Dans cet article nous présentons l’analyse linguistique d’un corpus de lettres luso- marocaines partiellement numérisées et conservées aux archives centrales portugaises. Ces documents datent tous de la première moitié du Xe/XVIe siècle et sont écrits en moyen arabe, un registre de langue écrite qui se caractérise par l’utilisation combinée de la langue classique et d’éléments dialectaux. L’objectif final de cette étude est de proposer quelques pistes pour retracer l’histoire des parlers arabes marocains modernes.
Fatigue strength of self-piercing riveted joints of carbon fiber reinforced composite and Al5052 alloy plates
Authors: Lee Ju-Ho , Oh Man-Jin , Kim HoKyung 
Published: July 2023

Self-piercing riveting (SPR) is an alternative to the conventional spot-welding method when joining sheets of dissimilar materials. In this study, the static and fatigue strengths of the SPR joints of carbon fiber composite laminate and an Al5052 aluminum alloy plate under various loading conditions were evaluated. Fatigue test results show that the load amplitudes, corresponding to the fatigue endurance limit, based on a lifetime of one million cycles, were 680 N, 323 N, and 305 N for loading angles of 0°, 45° and 90°, respectively, with corresponding fatigue ratios of the joints of 33%, 23% and 24%. The fatigue strengths at the loading angles of 45°, and 90° in terms of the equivalent stress intensity factor were found to be much higher than those at a loading angle of 0°. This is partially due to the difference in the fatigue failure modes. Regarding the fatigue strength designs of SPR joints consisting of composite laminate and aluminum alloy plates under various loads, it can be suggested that the tensile-shear strengths dominate the SPR fatigue strengths of the joints because they are highly vulnerable to tensile-shear loading.
Effects of a Mentoring Program for Black, Indigenous, and People of Color and First-Generation Public Health Students
Authors: Grilo Stephanie , Bryant Monét , Garbers Samantha , Wiggin Maggie , Samari Goleen 
Published: July 2023

Objectives: Among graduate public health students, Black, Indigenous, and other people of color (BIPOC; including Latinx, Asian, Middle Eastern and North African, Native Hawaiian and Pacific Islander, and multiracial) experience educational and personal challenges that require institutional support and reform. The objective of this study was to evaluate the effects of an antiracist mentorship program on the sense of belonging and overall experience among BIPOC and first-generation students at Columbia University Mailman School of Public Health in New York City. Methods: We used 2 data sources to retrospectively evaluate experiences of BIPOC and first-generation graduate students: the 2021 Mentoring of Students and Igniting Community (MOSAIC) Student Survey (n = 39), which collected data on experiences of students who participated in the MOSAIC program, and the 2016-2020 Graduate Exit Surveys (n = 1222), which collected data on graduating students’ experiences, satisfaction, and perspectives on diversity, equity, and inclusion. A difference-in-difference analysis compared overall experience, public health career preparedness, quality of life, and department satisfaction among all students before (2016-2018) and after (2019-2020) implementation of the MOSAIC program. Results: Satisfaction among graduate students attributable to the MOSAIC program introduced in 2019 increased by about 25%. Compared with students who had not been exposed to MOSAIC, students exposed to MOSAIC had a 25% positive difference ( P = .003) in overall graduate school experience, a 28% difference ( P < .001) in quality of life, and a 10% difference ( P = .001) in satisfaction with their departments. Conclusion: Mentorship for BIPOC and first-generation public health graduate students offers an effective strategy to improve student experiences and satisfaction with graduate departments and, ultimately, may help students meet educational and professional goals.
High-risk human papillomavirus infection among Nigerian women: A systematic review and meta-analysis
Authors: Ezechi Oliver , Akinsolu Folahanmi , Salako Abideen , Abodunrin Olunike , Adewole Ifeoluwa , Olagunju Mobolaji , Okunbor Hilary , Sanni-Adeniyi Rukayat , Zamba Emmanuella , Njuguna Diana Wangeshi , Eleje George 
Published: July 2023

Objective We conducted a systematic review and meta-analysis to determine the prevalence of high-risk human papillomavirus (hrHPV) infection and its associated risk factors among Nigerian women. Methods Databases including PubMed, Web of Science, Scopus, and CINAHL were searched for studies published between 01 January 2001 and 31 December 2022, that had reported hrHPV infection and associated risk factors among women in Nigeria from ages of 25 to 65 years. Results Of the 136 records initially retrieved, 18 were eligible for analysis. The prevalence of hrHPV genotypes was 25%, and for hrHPV 16 and 18, were 9% and 10%, respectively. The prevalence of hrHPV among HIV+ve women was 71%. The most common risk factors for hrHPV were age at coitarche and multiple sex partners. Conclusion hrHPV prevalence is high in women in Nigeria and common among those HIV+ve. Rapid screening for hrHPV genotypes is recommended, and multivalent HPV vaccines should be considered for women.
Oral vitamin D supplementation on the prevention of peritoneal dialysis-related peritonitis: A pilot randomised controlled trial
Authors: Zhang Yu-Hui , Xu Xiao , Pi Hai-Chen , Yang Zhi-Kai , Johnson David W , Dong Jie 
Published: July 2023

Objective: Peritoneal dialysis (PD)-related peritonitis is independently associated with low serum 25-hydroxy vitamin D [25(OH)D] levels. Our objective is to examine the feasibility of conducting a large, randomised controlled trial to determine the effects of vitamin D supplementation on the risk of PD-related peritonitis. Design: Pilot, prospective, open-label randomised controlled trial. Setting: Peking University First Hospital, China. Participants: Patients receiving PD who had recovered from a recent episode of peritonitis between 30 September 2017 and 28 May 2020. Interventions: Oral natural vitamin D supplementation (2000 IU per day) versus no vitamin D supplementation for 12 months. Primary and secondary outcome measures: Primary outcomes were feasibility (recruitment success, retention, adherence, safety) and fidelity (change in serum 25(OH)D level during follow-up) for a large, randomised controlled trial in the future to determine the effects of vitamin D on PD-related peritonitis. Secondary outcomes were time to peritonitis occurrence and outcome of subsequent peritonitis. Results: Overall, 60 among 151 patients were recruited (recruitment rate was 39.7%, 95% CI 31.9–47.5%, recruitment rate among eligible patients was 61.9%, 95% CI 52.2–71.5%). Retention and adherence rates were 100.0% (95% CI 100.0–100.0%) and 81.5% (95% CI 66.8–96.1%), respectively. During follow-up, serum 25(OH)D levels increased in the vitamin D (VD) group (from 19.25 ± 10.11 nmol/L to 60.27 ± 23.29 nmol/L after 6 months, p < 0.001, n = 31), and remained higher ( p < 0.001) than those in the control group ( n = 29). No differences were observed between the two groups with respect to time to subsequent peritonitis (hazard ratio 0.85, 95% CI 0.33–2.17) or any of the peritonitis outcomes. Adverse events were uncommon. Conclusions: A randomised controlled trial of the effect of vitamin D supplementation on peritonitis occurrence in patients receiving PD is feasible, safe and results in adequate serum 25(OH)D levels.