bluuebunny/crossref_metadata_2025_split huggingface dataset:
Succinic acid production by wine yeasts and the influence of GABA and glutamic acid
Authors: Torres-Guardado Rafael , Rozès Nicolás , Esteve-Zarzoso Braulio , Reguant Cristina , Bordons Albert 
Published: July 2023

AbstractAs a consequence of alcoholic fermentation (AF) in wine, several compounds are released by yeasts, and some of them are linked to the general quality and mouthfeel perceptions in wine. However, others, such as succinic acid, act as inhibitors, mainly of malolactic fermentation. Succinic acid is produced by non-Saccharomyces and Saccharomyces yeasts during the initial stages of AF, and the presence of some amino acids such as γ-aminobutyric acid (GABA) and glutamic acid can increase the concentration of succinic acid. However, the influence of these amino acids on succinic acid production has been studied very little to date. In this work, we studied the production of succinic acid by different strains of non-Saccharomyces and Saccharomyces yeasts during AF in synthetic must, and the influence of the addition of GABA or glutamic acid or a combination of both. The results showed that succinic acid can be produced by non-Saccharomyces yeasts with values in the range of 0.2–0.4 g/L. Moreover, the addition of GABA or glutamic acid can increase the concentration of succinic acid produced by some strains to almost 100 mg/L more than the control, while other strains produce less. Consequently, higher succinic acid production by non-Saccharomyces yeast in coinoculated fermentations with S. cerevisiae strains could represent a risk of inhibiting Oenococcus oeni and therefore the MLF.
d-Serine as a sensor and effector of the kidney
Authors: Kimura Tomonori , Sakai Shinsuke , Isaka Yoshitaka 
Published: July 2023

Abstractd-Serine, a rare enantiomer of serine, is a biomarker of kidney disease and function. The level of d-serine in the human body is precisely regulated through the urinary clearance of the kidney, and its clearance serves as a new measure of glomerular filtration rate with a lower bias than creatinine clearance. d-Serine also has a direct effect on the kidneys and mediates the cellular proliferation of tubular cells via mTOR signaling and induces kidney remodeling as a compensatory reaction to the loss of kidney mass. In living kidney donors, the removal of the kidney results in an increase in blood d-serine level, which in turn accelerates kidney remodeling and augments kidney clearance, thus reducing blood levels of d-serine. This feedback system strictly controls d-serine levels in the body. The function of d-serine as a biomarker and modulator of kidney function will be the basis of precision medicine for kidney diseases.
Bergbau und Naturschutzrecht
Authors: Frenz Walter 
Published: July 2023

ZusammenfassungDer Bergbau gilt als besonderes Feld des Naturschutzes. Kann dieser sich durchsetzen oder gilt dies umgekehrt für den Bergbau? Im Ansatz sind beide gleichgewichtig. Dieses Gleichgewicht bricht sich auch im Rahmen des geltenden Rechts Bahn. In den unionsrechtlich geregelten Bereichen ist ohnehin der Naturschutz vorrangig – oder doch mit Aufweichungen wie jetzt im Hinblick auf den Windkraftausbau, für den auch Rohstoffe nötig sind?
GPR81-mediated reprogramming of glucose metabolism contributes to the immune landscape in breast cancer
Authors: li Xiaofeng , Chen Yiwen , Wang Ting , Liu Zifan , Yin Guotao , Wang Ziyang , Sui Chunxiao , Zhu Lei , Chen Wei 
Published: July 2023

Abstract
Background
Local tumor microenvironment (TME) plays a crucial role in immunotherapy for breast cancer (BC). Whereas, the molecular mechanism responsible for the crosstalk between BC cells and surrounding immune cells remains unclear. The present study aimed to determine the interplay between GPR81-mediated glucometabolic reprogramming of BC and the immune landscape in TME.

Materials and Methods
Immunohistochemistry (IHC) assay was first performed to evaluate the association between GPR81 and the immune landscape. Then, several stable BC cell lines with down-regulated GPR81 expression were established to directly identify the role of GPR81 in glucometabolic reprogramming, and western blotting assay was used to detect the underlying molecular mechanism. Finally, a transwell co-culture system confirmed the crosstalk between glucometabolic regulation mediated by GPR81 in BC and induced immune attenuation.

Results
IHC analysis demonstrated that the representation of infiltrating CD8+ T cells and FOXP3+ T cells were dramatically higher in BC with a triple negative (TN) subtype in comparison with that with a non-TN subtype (P < 0.001). Additionally, the ratio of infiltrating CD8+ to FOXP3+ T cells was significantly negatively associated with GPR81 expression in BC with a TN subtype (P < 0.001). Furthermore, GPR81 was found to be substantially correlated with the glycolytic capability (P < 0.001) of BC cells depending on a Hippo-YAP signaling pathway (P < 0.001). In the transwell co-culture system, GPR81-mediated reprogramming of glucose metabolism in BC significantly contributed to a decreased proportion of CD8+ T (P < 0.001) and an increased percentage of FOXP3+ T (P < 0.001) in the co-cultured lymphocytes.

Conclusion
Glucometabolic reprogramming through a GPR81-mediated Hippo-YAP signaling pathway was responsible for the distinct immune landscape in BC. GPR81 was a potential biomarker to stratify patients before immunotherapy to improve BC’s clinical prospect.
Late Holocene coastal dynamics south of the Chanthaburi estuary, eastern Gulf of Thailand
Authors: Ballian Armelle , Chawchai Sakonvan , Miocic Johannes M. , Charoenchatree Warinyupa , Bissen Raphael , Preusser Frank 
Published: July 2023

AbstractBeach ridges are depositional features that allow reconstruction of past sea-level variations, sediment dynamics, and storm activity. However, there are still very few systematic studies focusing on beach ridges available from the Gulf of Thailand. Along the east coast, satellite images provide evidence of beach ridges in the Chanthaburi Province, extending as far as 6 km inland, oriented parallel to the current coastline. These can be divided into a set of landward ridges (5.3–6.0 km inland) and seaward ridges (0.4–1.8 km inland) that are separated by an arm of the Chanthaburi estuary. Optically stimulated luminescence dating of 26 sand samples from 12 pits of ridge profiles suggests that the landward set of beach ridges formed ca. 3500 yr ago, while the seaward set of ridges formed between ca. 2100–1200 years ago, which also includes the modern active beach. It appears that the landward set of beach ridges developed during a period of relatively stable sea level followed by a rapid regression presently occupied by the arm of the Chanthaburi estuary. The seaward set of beach ridges apparently reflects a millennium of slowly retreating coastline until the modern beach ridge formed.
Imposing a Lifestyle: A New Argument for Antinatalism
Authors: Häyry Matti , Sukenick Amanda 
Published: July 2023

AbstractAntinatalism is an emerging philosophy and practice that challenges pronatalism, the prevailing philosophy and practice in reproductive matters. We explore justifications of antinatalism—the arguments from the quality of life, the risk of an intolerable life, the lack of consent, and the asymmetry of good and bad—and argue that none of them supports a concrete, understandable, and convincing moral case for not having children. We identify concentration on possible future individuals who may or may not come to be as the main culprit for the failure and suggest that the focus should be shifted to people who already exist. Pronatalism’s hegemonic status in contemporary societies imposes upon us a lifestyle that we have not chosen yet find almost impossible to abandon. We explicate the nature of this imposition and consider the implications of its exposure to different stakeholders with varying stands on the practice of antinatalism. Imposition as a term has figured in reproductive debates before, but the argument from postnatal, mental, and cultural imposition we launch is new. It is the hitherto overlooked and underdeveloped justification of antinatalism that should be solid and comprehensible enough to be used even by activists in support of their work.
Aiding Higher Education with Export Expansion in the Developing World
Authors: Suzuki Motoshi 
Published: July 2023

AbstractThe recent change towards advanced technologies favors skill-intensive labor, motivating workers to upgrade their educational achievements to the tertiary level. However, workers in many developing countries cannot exploit the opportunity for premium wages in skill-intensive sectors owing to insufficient education facilities and resources. In such contexts, aid to education provides a capacity-building tool to eliminate the insufficiency but is often unsuccessful. Using theories of trade and human capital, this study argues that complementarity between education aid and skill-intensive manufactured exports creates a synergistic effect in upgrading educational achievements by rectifying both structural and incentive constraints. Through extensive data analysis, the result demonstrates that skill-intensive exports enhance aid's effectiveness in increasing tertiary school enrollment, whereas neither exports nor aid alone significantly affect enrollment. It further shows that the aid–export complementarity is less relevant in low-income countries, whereas skill-intensive exports alone promote education upgrading in developed countries via the Stolper–Samuelson effect.
Early EEG-burst sharpness and 2-year disability in extremely preterm infants
Authors: Plomgaard Anne Mette , Stevenson Nathan , Roberts James A. , Hvass Petersen Tue , Vanhatalo Sampsa , Greisen Gorm ,   the SafeBoosC-II study group, Pellicer Adelina , Fumagalli Monica , Lemmers Petra , Pichler Gerhard , Dempsey Eugene , Claris Olivier , Hyttel-Sorensen Simon 
Published: July 2023

Abstract
Background
Automated computational measures of EEG have the potential for large-scale application. We hypothesised that a predefined measure of early EEG-burst shape (increased burst sharpness) could predict neurodevelopmental impairment (NDI) and mental developmental index (MDI) at 2 years of age over-and-above that of brain ultrasound.

Methods
We carried out a secondary analysis of data from extremely preterm infants collected for an RCT (SafeBoosC-II). Two hours of single-channel cross-brain EEG was used to analyse burst sharpness with an automated algorithm. The co-primary outcomes were moderate-or-severe NDI and MDI. Complete data were available from 58 infants. A predefined statistical analysis was adjusted for GA, sex and no, mild–moderate, and severe brain injury as detected by cranial ultrasound.

Results
Nine infants had moderate-or-severe NDI and the mean MDI was 87 ± 17.3 SD. The typical burst sharpness was low (negative values) and varied relatively little (mean –0.81 ± 0.11 SD), but the odds ratio for NDI was increased by 3.8 (p = 0.008) and the MDI was reduced by –3.2 points (p = 0.14) per 0.1 burst sharpness units increase (+1 SD) in the adjusted analysis.

Conclusion
This study confirms the association between EEG-burst measures in preterm infants and neurodevelopment in childhood. Importantly, this was by a priori defined analysis.

Impact

A fully automated, computational measure of EEG in the first week of life was predictive of neurodevelopmental impairment at 2 years of age.

This confirms many previous studies using expert reading of EEG.

Only single-channel EEG data were used, adding to the applicability.

EEG was recorded by several different devices thus this measure appears to be robust to differences in electrodes, amplifiers and filters.

The likelihood ratio of a positive EEG test, however, was only about 2, suggesting little immediate clinical value.
Pharmacological bioactivity of Ceratonia siliqua pulp extract: in vitro screening and molecular docking analysis, implication of Keap-1/Nrf2/NF-ĸB pathway
Authors: El-Zeftawy Marwa , Ghareeb Doaa 
Published: July 2023

AbstractInflammation is interfaced with various metabolic disorders. Ceratonia siliqua (CS) has a higher pharmaceutical purpose. The research aimed to investigate the biofunction of CS pulp aqueous extract (CS-PAE) with an emphasis on its integrated computational approaches as opposed to different specific receptors contributing to inflammation. The extract was assessed for its chemical and phenolic components via GC–MS, LC–MS, HPLC, and total phenolic and flavonoid content. In vitro, bioactivities and molecular docking were analyzed. Findings indicate that CS-PAE demonstrated higher scavenging activities of nitric oxide, 1,1-diphenyl-2-picrylhydrazyl radical, superoxide anion, hydrogen peroxide, and anti-lipid peroxidation (IC50 values were 5.29, 3.04, 0.63, 7.35 and 9.6 mg/dl, respectively). The extract revealed potent inhibition of RBCs hemolysis, acetylcholine esterase, monoamine oxidase-B, and α-glucosidase enzymes (IC50 was 13.44, 9.31, 2.45, and 1.5 mg/dl, respectively). The extract exhibited a cytotoxic effect against prostate cancer Pc3, liver cancer HepG2, colon cancer Caco2, and lung cancer A549 cell lines. Moreover, CS-PAE owned higher antiviral activity against virus A and some bacteria. When contrasting data from molecular docking, it was reported that both apigenin-7-glucoside and rutin in CS-PAE have a good affinity toward the Keap-1/Nrf2/ NF-ĸB pathway. In conclusion, CS-PAE showed promise in therapeutic activity in metabolic conditions.
The role of early synthetic materials degradation in the downfall of the Ansaldo A.1, an Italian World War I biplane fighter
Authors: La Nasa Jacopo , Ceccarini Alessio , Ducoli Riccardo , Manariti Antonella , Lucejko Jeanette J. , Degano Ilaria , Capra Neva , Giovannini Lucia , Tomasi Maria Luisa , Modugno Francesca , Colombini Maria Perla , Bonaduce Ilaria 
Published: July 2023

AbstractFrom the Pioneer Era of the aviation to World War I the evolution of aircraft technology and chemical synthesis enabled a unique coexistence of traditional craftsmanship, artistic decoration practices, and technological advancements. The study of the materials used in these early years of aviation is still an uncharted territory: a vast portion of remaining planes has been partially or completely repaired and restored, usually by total replacement of the fabric. The Italian biplane Ansaldo A.1 (1918) is a fighter aircraft and is one of the few planes in the world that still preserves its own original materials. In the last years, the fabric sections of the airplane have started to become brittle and loose cohesion, severely compromising the integrity of the aircraft, and resulting in a general alteration of the pictorial layers of the painted sections. A chemical investigation was undertaken to unveil the materials, and to elucidate the causes of the degradation. This study presents one of the first steps into the study of early historical aircrafts, defining the background for the conservation plans to preserve these objects for future generations.
Study on the spatial spillover effect of land use type change on carbon emissions
Authors: Zhang Ruiwu , Ying Jun , Zhang Yiqi 
Published: July 2023

AbstractLand use change affects the terrestrial carbon cycle, a crucial factor in attaining energy conservation and emission reduction under climate change. This study constructs panel data for thirteen Hangzhou districts and municipalities from 2000 to 2020. Using the spatial Durbin model, it analyzes the spatial spillover effect of land use change on carbon emissions. The results show that the spatial distribution of carbon emissions in Hangzhou continues to increase with positive spatial autocorrelation, and the spatial distribution shows "high-high" and "low-low" clustering. The expansion of construction land is the main reason for the increase in carbon emissions, and the inhibitory effect of water area on carbon emissions is more potent than woodland. The area of cultivated land and construction land has a positive spillover effect on carbon emissions, while the woodland area has a negative spillover effect on carbon emissions. To promote urban low-carbon development, maximizing the spatial spillover effect of land use and establishing a collaborative governance system between districts and counties is crucial.
Association between CCR2 and CCL2 expression and NET stimulation in adult-onset Still’s disease
Authors: Jung Ju-Yang , Ahn Mi-Hyun , Kim Ji-Won , Suh Chang-Hee , Han Jae Ho , Kim Hyoun-Ah 
Published: July 2023

AbstractAdult-onset Still’s disease (AOSD) is a systemic inflammatory disease characterized by the activation of monocyte-derived cells and the release of neutrophil extracellular traps (NET). C–C motif ligand (CCL) 2 is a chemoattractant that interacts with the C–C motif chemokine receptor (CCR) 2, resulting in monocyte recruitment and activation. CCL2 and CCR2 were measured with enzyme-linked immunosorbent assay (ELISA) at the serum level, and using immunohistochemical staining at the skin and lymph node tissues levels. THP-1 cell lysates were analyzed using western blot and ELISA after NET stimulation in patients with AOSD. Serum CCL2 level was higher in patients with AOSD than in patients with rheumatoid arthritis and healthy controls (HCs). In patients with AOSD, the percentage of CCL2-positive inflammatory cells in the skin tissues and CCR2-positive inflammatory cells in the lymph nodes increased, compared to that in HCs and in patients with reactive lymphadenopathy, respectively. NET induced in patients with AOSD enhanced the secretion of CCR2, higher CCR2 expression in monocytes, and the levels of interleukin (IL)-1β, IL-6, and IL-18 from THP-1 cells. Our findings suggest that upregulation of the CCL2–CCR2 axis may contribute to the clinical and inflammatory characteristics of AOSD.
Deep features fusion for user authentication based on human activity
Authors: Wandji Piugie Yris Brice , Charrier Christophe , Di Manno Joël , Rosenberger Christophe 
Published: July 2023

AbstractThe exponential growth in the use of smartphones means that users must constantly be concerned about the security and privacy of mobile data because the loss of a mobile device could compromise personal information. To address this issue, continuous authentication systems have been proposed, in which users are monitored transparently after initial access to the smartphone. In this study, the authors address the problem of user authentication by considering human activities as behavioural biometric information. The authors convert the behavioural biometric data (considered as time series) into a 2D colour image. This transformation process keeps all the characteristics of the behavioural signal. Time series does not receive any filtering operation with this transformation, and the method is reversible. This signal‐to‐image transformation allows us to use the 2D convolutional networks to build efficient deep feature vectors. This allows them to compare these feature vectors to the reference template vectors to compute the performance metric. The authors evaluate the performance of the authentication system in terms of Equal Error Rate on a benchmark University of Californy, Irvine Human Activity Recognition dataset, and they show the efficiency of the approach.
Simplification of DFT and IDFT in PRACH
Authors: Jiang Yufeng , Kang Shouxin 
Published: July 2023

AbstractThe respective simplifications of prime‐point discrete Fourier transform (DFT) and ultra‐long‐point inverse discrete Fourier transform (IDFT) in physical random access channel (PRACH) are proposed. The former is an equivalent substitution of DFT function by using the property of Zadoff‐Chu (ZC) sequence, and the latter is an approximation based on cubic spline interpolation, which not only reduces the IDFT points, but also is easy to construct.
Wide angle SAR imaging method based on hybrid representation
Authors: Zhao Yao , Chen Yanxu , Tian He , Quan Xiangyin , Ling Bingo Wing‐Kuen , Zhang Zhe 
Published: July 2023

AbstractIn this paper, the application of a hybrid representation in wide‐angle synthetic aperture radar (WASAR) imaging is investigated, addressing the challenge of achieving sparse representation in the presence of complex electromagnetic scattering characteristics and highly anisotropic targets. A convolutional neural network is utilized to represent the two‐dimensional data within each azimuth aperture, while employing blind compressed sensing (BCS) to achieve sparse representation across different azimuth apertures. Convolutional neural network (CNN) excels in learning spatial hierarchies and local dependencies of two‐dimensional data but requires a large amount of training data. Isotropic targets within each azimuth aperture can be used for training conventional SAR data, while acquiring training samples for anisotropic targets poses challenges. To address this issue, BCS are integrated into WASAR imaging, eliminating the need for additional training data. By integrating these methods, a novel approach called hybrid‐WASAR is proposed, which incorporates two regularization terms into WASAR imaging and employs the alternating direction method of multipliers to iteratively solve the imaging model. Compared to traditional WASAR imaging techniques, hybrid‐WASAR improves the accuracy of reconstructing the backscattering coefficients of the targets, leading to a significant enhancement in overall imaging quality.
A dilating and embedding scheme for constructing sparse MIMO radar array
Authors: Zhang Baohua , Guo Yiming , Liu Guangyi , Mei Fengtong , Shen Zhixiang 
Published: July 2023

AbstractIn this letter, a dilating and embedding scheme for constructing sparse multiple‐input and multiple‐output radar arrays is addressed, which seeks to increase the uniform degrees of freedom (uDOFs) and reduce the mutual coupling effects for a given number of transmitters and receivers (Tx/Rx). According to this scheme, a dilated maximum inter‐element spacing constraint (MISC) array with an embedded thinned coprime array in the collocated MIMO radar for DOA estimation is proposed. Theoretical analysis shows that the proposed array can provide higher uDOFs and is robust in a scenario with heavy levels of mutual coupling. Numerical simulations are conducted to validate its aforementioned advantages in line with the design scheme.
MDSC‐Net: A multi‐scale depthwise separable convolutional neural network for skin lesion segmentation
Authors: Jiang Yun , Qiao Hao , Zhang Zequn , Wang Meiqi , Yan Wei , Chen Jie 
Published: July 2023

AbstractAccurate segmentation of the skin lesion region is crucial for diagnosing and screening skin diseases. However, skin lesion segmentation is challenging due to the indistinguishable boundaries of the lesion region, irregular shapes and hair interference. To settle the above issues, we propose a Multi‐scale Depthwise Separable Convolutional Neural Network for skin lesion segmentation named MDSC‐Net. Specifically, a novel Multi‐scale Depthwise Separable Residual Convolution Module is employed in skip connection, conveying more detailed features to the decoder. To compensate for the loss of spatial location information in down‐sampling, we propose a novel Spatial Adaption Module. Furthermore, we propose a Multi‐scale Decoding Fusion Module in the decoder to capture contextual information. We have performed extensive experiments to verify the effectiveness and robustness of the proposed network on three public benchmark skin lesion segmentation datasets and one public benchmark polyp segmentation dataset, including ISIC‐2017, ISIC‐2018, PH2, and Kvasir‐SEG datasets. Experimental results consistently demonstrate the proposed MDSC‐Net achieves superior segmentation across five popularly used evaluation criteria. The proposed network reaches high‐performance skin lesion segmentation, and can provide important clues to help doctors diagnose and treat skin cancer early.