bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinetics of Grain Size Reduction in Minerals Undergoing Ball Milling
Authors: Sanna Anna Laura , Pia Giorgio , Delogu Francesco 
Published: July 2023

AbstractThis work focuses on the grain size reduction induced by ball milling in individual minerals and binary mixtures containing quartz and a softer mineral. All the investigated minerals and mineral mixtures undergo a significant monotonic grain size decrease upon mechanical processing. The rate at which the process occurs in individual minerals decreases with the hardness of the mineral phase. Hardness is shown to play a crucial role also in the case of mineral mixtures. The final grain size attainable by the softer mineral as well as the rate of the grain size reduction process depend, indeed, on the amount of quartz in the mixture. A kinetic model allows rationalizing the observed behaviour based on the intensity of mechanical stresses generated during individual impacts.
Numerical Investigation of Fredholm Fractional Integro-differential Equations by Least Squares Method and Compact Combination of Shifted Chebyshev Polynomials
Authors: Benzahi Ahlem , Arar Nouria , Abada Nadjet , Rhaima Mohamed , Mchiri Lassaad , Makhlouf Abdellatif Ben 
Published: July 2023

AbstractIn this study, linear Fredholm fractional integro-differential equations (FIDEs) are numerically solved, where the fractional derivative is considered in the Caputo sense. In this work, the least squares method (LSM) using a compact combination of shifted Chebyshev polynomials (SCP) of the first Kind is applied to solving a class of FIDEs. Our aim is to write the unknown function as a series of a linear combination of SCP, and then to reduce the problem to a system of linear algebraic equations, which will be solved for the unknown constants associated with the approximate solution, using MATLAB R2020a. Finally, numerical examples are presented to confirm the reliability, applicability, and efficiency of this method, in addition, various comparisons are also shown.
Automatic threat processing shows evidence of exclusivity
Authors: March David S. , Olson Michael A. , Gaertner Lowell 
Published: July 2023

Abstract
De Neys argues against assigning exclusive capacities to automatic versus controlled processes. The dual implicit process model provides a theoretical rationale for the exclusivity of automatic threat processing, and corresponding data provide empirical evidence of such exclusivity. De Neys's dismissal of exclusivity is premature and based on a limited sampling of psychological research.
When a thinker does not want to think: Adding meta-control into the working model
Authors: Sirota Miroslav 
Published: July 2023

Abstract
De Neys proposes an elegant solution to several theoretical problems of the dual-process theories but underspecifies the role of motivation in initiating, intensifying, and ceasing deliberation. Therefore, I suggest including a meta-cognitive control component in the working model that can moderate deliberation, for instance by affecting the deliberation threshold.
Overturning Pathways Control AMOC Weakening in CMIP6 Models
Authors: Baker Jonathan A. , Bell Michael J. , Jackson Laura C. , Renshaw Richard , Vallis Geoffrey K. , Watson Andrew J. , Wood Richard A. 
Published: July 2023

AbstractFuture projections indicate the Atlantic Meridional Overturning Circulation (AMOC) will weaken and shoal in response to global warming, but models disagree widely over the amount of weakening. We analyze projected AMOC weakening in 27 CMIP6 climate models, in terms of changes in three return pathways of the AMOC. The branch of the AMOC that returns through diffusive upwelling in the Indo‐Pacific, but does not later upwell in the Southern Ocean (SO), is particularly sensitive to warming, in part, because shallowing of the deep flow prevents it from entering the Indo‐Pacific via the SO. The present‐day strength of this Indo‐Pacific pathway provides a strong constraint on the projected AMOC weakening. However, estimates of this pathway using four observationally based methods imply a wide range of AMOC weakening under the SSP5‐8.5 scenario of 29%–61% by 2100. Our results suggest that improved observational constraints on this pathway would substantially reduce uncertainty in 21st century AMOC decline.
Disruption of trait-environment relationships in African megafauna occurred in the middle Pleistocene
Authors: Lauer Daniel A. , Lawing A. Michelle , Short Rachel A. , Manthi Fredrick K. , Müller Johannes , Head Jason J. , McGuire Jenny L. 
Published: July 2023

AbstractMammalian megafauna have been critical to the functioning of Earth’s biosphere for millions of years. However, since the Plio-Pleistocene, their biodiversity has declined concurrently with dramatic environmental change and hominin evolution. While these biodiversity declines are well-documented, their implications for the ecological function of megafaunal communities remain uncertain. Here, we adapt ecometric methods to evaluate whether the functional link between communities of herbivorous, eastern African megafauna and their environments (i.e., functional trait-environment relationships) was disrupted as biodiversity losses occurred over the past 7.4 Ma. Herbivore taxonomic and functional diversity began to decline during the Pliocene as open grassland habitats emerged, persisted, and expanded. In the mid-Pleistocene, grassland expansion intensified, and climates became more variable and arid. It was then that phylogenetic diversity declined, and the trait-environment relationships of herbivore communities shifted significantly. Our results divulge the varying implications of different losses in megafaunal biodiversity. Only the losses that occurred since the mid-Pleistocene were coincident with a disturbance to community ecological function. Prior diversity losses, conversely, occurred as the megafaunal species and trait pool narrowed towards those adapted to grassland environments.
Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein
Authors: Russell Lewis Benjamin , Uddin Muhammad R. , Moniruzzaman Mohammad , Kuo Katie M. , Higgins Anna J. , Shah Laila M. N. , Sobott Frank , Parks Jerry M. , Hammerschmid Dietmar , Gumbart James C. , Zgurskaya Helen I. , Reading Eamonn 
Published: July 2023

AbstractMembrane efflux pumps play a major role in bacterial multidrug resistance. The tripartite multidrug efflux pump system fromEscherichia coli, AcrAB-TolC, is a target for inhibition to lessen resistance development and restore antibiotic efficacy, with homologs in other ESKAPE pathogens. Here, we rationalize a mechanism of inhibition against the periplasmic adaptor protein, AcrA, using a combination of hydrogen/deuterium exchange mass spectrometry, cellular efflux assays, and molecular dynamics simulations. We define the structural dynamics of AcrA and find that an inhibitor can inflict long-range stabilisation across all four of its domains, whereas an interacting efflux substrate has minimal effect. Our results support a model where an inhibitor forms a molecular wedge within a cleft between the lipoyl and αβ barrel domains of AcrA, diminishing its conformational transmission of drug-evoked signals from AcrB to TolC. This work provides molecular insights into multidrug adaptor protein function which could be valuable for developing antimicrobial therapeutics.
Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer
Authors: Jiang Zhe , Ju YoungJun , Ali Amjad , Chung Philip E. D. , Skowron Patryk , Wang Dong-Yu , Shrestha Mariusz , Li Huiqin , Liu Jeff C. , Vorobieva Ioulia , Ghanbari-Azarnier Ronak , Mwewa Ethel , Koritzinsky Marianne , Ben-David Yaacov , Woodgett James R. , Perou Charles M. , Dupuy Adam , Bader Gary D. , Egan Sean E. , Taylor Michael D. , Zacksenhaus Eldad 
Published: July 2023

AbstractMetastatic breast-cancer is a major cause of death in women worldwide, yet the relationship between oncogenic drivers that promote metastatic versus primary cancer is still contentious. To elucidate this relationship in treatment-naive animals, we hereby describe mammary-specific transposon-mutagenesis screens in female mice together with loss-of-function Rb, which is frequently inactivated in breast-cancer. We report gene-centric common insertion-sites (gCIS) that are enriched in primary-tumors, in metastases or shared by both compartments. Shared-gCIS comprise a major MET-RAS network, whereas metastasis-gCIS form three additional hubs: Rho-signaling, Ubiquitination and RNA-processing. Pathway analysis of four clinical cohorts with paired primary-tumors and metastases reveals similar organization in human breast-cancer with subtype-specific shared-drivers (e.g. RB1-loss, TP53-loss, high MET, RAS, ER), primary-enriched (EGFR, TGFβ and STAT3) and metastasis-enriched (RHO, PI3K) oncogenic signaling. Inhibitors of RB1-deficiency or MET plus RHO-signaling cooperate to block cell migration and drive tumor cell-death. Thus, targeting shared- and metastasis- but not primary-enriched derivers offers a rational avenue to prevent metastatic breast-cancer.
Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3
Authors: Kornienko Julia , Rodríguez-Martínez Marta , Fenzl Kai , Hinze Florian , Schraivogel Daniel , Grosch Markus , Tunaj Brigit , Lindenhofer Dominik , Schraft Laura , Kueblbeck Moritz , Smith Eric , Mao Chad , Brown Emily , Owens Anjali , Saguner Ardan M. , Meder Benjamin , Parikh Victoria , Gotthardt Michael , Steinmetz Lars M. 
Published: July 2023

AbstractSevere forms of dilated cardiomyopathy (DCM) are associated with point mutations in the alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich domain (RS-domain). Such mutations can cause defective splicing and cytoplasmic mislocalization, which leads to the formation of detrimental cytoplasmic granules. Successful development of personalized therapies requires identifying the direct mechanisms of pathogenic RBM20 variants. Here, we decipher the molecular mechanism of RBM20 mislocalization and its specific role in DCM pathogenesis. We demonstrate that mislocalized RBM20 RS-domain variants retain their splice regulatory activity, which reveals that aberrant cellular localization is the main driver of their pathological phenotype. A genome-wide CRISPR knockout screen combined with image-enabled cell sorting identified Transportin-3 (TNPO3) as the main nuclear importer of RBM20. We show that the direct RBM20-TNPO3 interaction involves the RS-domain, and is disrupted by pathogenic variants. Relocalization of pathogenic RBM20 variants to the nucleus restores alternative splicing and dissolves cytoplasmic granules in cell culture and animal models. These findings provide proof-of-principle for developing therapeutic strategies to restore RBM20’s nuclear localization in RBM20-DCM patients.
Topotactic fabrication of transition metal dichalcogenide superconducting nanocircuits
Authors: Wang Xiaohan , Wang Hao , Ma Liang , Zhang Labao , Yang Zhuolin , Dong Daxing , Chen Xi , Li Haochen , Guan Yanqiu , Zhang Biao , Chen Qi , Shi Lili , Li Hui , Qin Zhi , Tu Xuecou , Zhang Lijian , Jia Xiaoqing , Chen Jian , Kang Lin , Wu Peiheng 
Published: July 2023

AbstractSuperconducting nanocircuits, which are usually fabricated from superconductor films, are the core of superconducting electronic devices. While emerging transition-metal dichalcogenide superconductors (TMDSCs) with exotic properties show promise for exploiting new superconducting mechanisms and applications, their environmental instability leads to a substantial challenge for the nondestructive preparation of TMDSC nanocircuits. Here, we report a universal strategy to fabricate TMDSC nanopatterns via a topotactic conversion method using prepatterned metals as precursors. Typically, robust NbSe2 meandering nanowires can be controllably manufactured on a wafer scale, by which a superconducting nanowire circuit is principally demonstrated toward potential single photon detection. Moreover, versatile superconducting nanocircuits, e.g., periodical circle/triangle hole arrays and spiral nanowires, can be prepared with selected TMD materials (NbS2, TiSe2, or MoTe2). This work provides a generic approach for fabricating nondestructive TMDSC nanocircuits with precise control, which paves the way for the application of TMDSCs in future electronics.
Interconnectedness enhances network resilience of multimodal public transportation systems for Safe-to-Fail urban mobility
Authors: Xu Zizhen , Chopra Shauhrat S. 
Published: July 2023

AbstractThe growing interconnectedness of urban infrastructure networks presents challenges to their ability to handle unforeseen disruptions, particularly in the context of extreme weather events resulting from climate change. Understanding the resilience of interconnected infrastructure systems is imperative to effectively manage such disruptions. This study investigates the role of interconnectedness in enhancing the resilience of public transportation systems in Hong Kong, a city heavily reliant on public transit. Our results demonstrate that interconnected transportation systems improve resilience by reducing topological vulnerabilities, increasing attack tolerance, and enhancing post-disruption interoperability. Findings also identify the potential to integrate vulnerable systems for greater robustness and highlight the marginal benefits of enhancing intermodal transfer. Strengthening interconnectedness among modes of urban public transit fosters a safe-to-fail system, presenting a distinct resilience-by-design approach. This complements conventional resilience-by-intervention approaches that focus on improving individual systems or introducing entirely new systems.
Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer
Authors: Babic Ana , Rosenthal Michael H. , Sundaresan Tilak K. , Khalaf Natalia , Lee Valerie , Brais Lauren K. , Loftus Maureen , Caplan Leah , Denning Sarah , Gurung Anamol , Harrod Joanna , Schawkat Khoschy , Yuan Chen , Wang Qiao-Li , Lee Alice A. , Biller Leah H. , Yurgelun Matthew B. , Ng Kimmie , Nowak Jonathan A. , Aguirre Andrew J. , Bhatia Sangeeta N. , Vander Heiden Matthew G. , Van Den Eeden Stephen K. , Caan Bette J. , Wolpin Brian M. 
Published: July 2023

AbstractPatients with pancreatic cancer commonly develop weight loss and muscle wasting. Whether adipose tissue and skeletal muscle losses begin before diagnosis and the potential utility of such losses for earlier cancer detection are not well understood. We quantify skeletal muscle and adipose tissue areas from computed tomography (CT) imaging obtained 2 months to 5 years before cancer diagnosis in 714 pancreatic cancer cases and 1748 matched controls. Adipose tissue loss is identified up to 6 months, and skeletal muscle wasting is identified up to 18 months before the clinical diagnosis of pancreatic cancer and is not present in the matched control population. Tissue losses are of similar magnitude in cases diagnosed with localized compared with metastatic disease and are not correlated with at-diagnosis circulating levels of CA19-9. Skeletal muscle wasting occurs in the 1–2 years before pancreatic cancer diagnosis and may signal an upcoming diagnosis of pancreatic cancer.
Toxic and non-toxic dinoflagellates host distinct bacterial communities in their phycospheres
Authors: Deng Yunyan , Wang Kui , Hu Zhangxi , Hu Qiang , Tang Ying Zhong 
Published: July 2023

AbstractDinoflagellates encompass highly abundant and diverse toxin-producing species among marine phytoplankton. Previous works suggested that some bacterial taxa may affect toxins production in dinoflagellates, however, little is known about impact of toxic dinoflagellates on their co-existing bacterial flora. Here we characterized the bacterial communities associated with 22 clonal cultures of dinoflagellates using DNA metabarcoding method, including 11 confirmed toxic species and 11 species that have not been reported to be toxic. Beta diversity analysis revealed that all the 11 species in toxic group were clustered together and distinctly separated from non-toxic group, strongly suggesting the bacterial community composition was largely influenced by toxic dinoflagellate hosts. The toxic group was found to include higher relative abundance of non-carbohydrate utilizers and xenobiotic-degrading taxa and showed inhibitory effects on algicidal bacteria. These findings suggested that toxic dinoflagellates host bacterial communities distinctive from non-toxic species in multiple ways in their phycospheres.
The Smoluchowski–Kramer approximation of a generalized Langevin equation with state-dependent damping
Authors: Wang Shaoteng , Wang Wei 
Published: July 2023

Abstract
The small-mass limit is derived for a generalized Langevin equation (GLE) with state-dependent damping and a kernel expressed as an infinite sum of exponentials. The state dependence includes both the current and the past. By some bounded estimates and tightness, as the mass tends to 0, the GLE is shown to converge in distribution to a limit equation with additional drift terms that come from the current and the past state dependence, respectively.
Endurance Strength and Residual Life Assessment of T23 Steel after 96000 Hours of High Temperature and High Pressure Service
Authors: Yang Jia , Cai Yuanzong , Lu Li , Wang Yuwei , Liang Zhenxin , Cai Zhipeng , Sun Qian 
Published: July 2023

Abstract
The macroscopic morphology, oxide layer characteristics, rupture strength and residual life of T23 steel after 96000 hours of service at high temperature and high pressure were analyzed. The results show that T23 steel pipe has good macroscopic appearance, without obvious abnormal features such as cracks, folds, rolling breaks, double skin, scabs, delaminations and sharp scratches. The chemical composition of different pipe sections conforms to the standard, and the structure is mainly bainite, with uniform distribution and no obvious coarse phase. There is an obvious interface between the metal substrate and the internal oxide layer, and there is an obvious wavy line at the interface. The oxide layer is relatively dense and continuous. The tensile properties at room temperature and high temperature are good. At room temperature, the yield strength exceeds 420MPa, the tensile strength exceeds 540MPa, and the elongation exceeds 19%. After 96000 hours of use, the remaining creep life of T23 split platen superheater submitted for inspection is 84000 hours, and the remaining creep life of T23 rear platen superheater submitted for inspection is 40000 hours.
Fuzzy Structured Element Integrated Decision of Metamorphism on Coal Dust Ignition Hazard Rating
Authors: Dong Xiaoting , Liu Tianqi , Wang Xiaoyi , Xu Xiaoliang 
Published: July 2023

Abstract
To discuss the coal dust ignition hazard rating of different metamorphism, the fuzzy structure element integrated decision model about “no danger”, “weak danger”, “general danger”, and “strong danger” of coal dust ignition is established. 40 kinds of coal samples are selected to carry out coal quality analysis test, overpressure test, temperature test, flame propagation properties test and particle size distribution test. Based on this, coal dust ignition hazard rating decision-making index system is built. The triangular structure element is added to fuzzy comprehensive decision model, by sequencing weighted Hamming distance between fuzzy index value function and fuzzy maximal function, the coal dust ignition hazard rating of different coal quality can be decided. The result shows that: with increasing metamorphic grade, coal dust ignition hazard rating is decreasing, which provides study basis for relation between metamorphism and ignition hazard rating.
Numerical Simulation of Train-Induced Structural Vibration
Authors: Lin Gang , Liu Donghuan 
Published: July 2023

Abstract
Train-induced structural vibration caused more and more attentions nowadays, and the present paper developed a numerical approach of train-induced structural vibration simulation with ANSYS software. The finite element model is composed by buildings, rail, sleepers, ballast and several layers of soil, and the moving load is represented by wheel-rail coupling forces, and both solid element, shell element and beam element are used in the finite element model. Acceleration time history and vibration levels of the key point on the buildings are given, and effect of different wheel-rail coupling forces and the dynamic response of the building are also numerically investigated. Comparisons of free boundary, symmetric boundary, fixed boundary and transmitting boundary conditions on the dynamic responses are also illustrated. Numerical results show that, both boundary condition and load type could affect the dynamic response of the structures near the train tracks, and validation test should be performed firstly to determine the proper boundary condition and load amplitude and frequency. The proposed numerical method provides a powerful technic tool for numerically predicting the dynamic response of train-induce structural vibration, and could also be employed to evaluate the vibration control results of different approaches.
Research on Local Structure Plastic Damage of Cylindrical Shell under Near-field Underwater Explosion
Authors: Yang Di , Luo Wei , Li Fei , Gong Yufeng , Zhao Yongcai , Li Sheng 
Published: July 2023

Abstract
The local structure of the cylindrical shell produces plastic deformation under the near-field underwater explosion load, based on the fact that the ring rib is the strong support of reinforced cylindrical shell plate, this paper simplifies the reinforced cylindrical shell model into a rigid slatted beam model at both ends, and lists the equations of slatted beams under the action of shock wave and bubble pulsation load. This equation takes the initial damage caused by shock wave into account, and compares the calculation results obtained by the theoretical method with the experimental data, which verifies the correctness of this mechanical model. At the same time, it is explained that this calculation method can better predict the plastic damage of the local structure of the cylindrical shell under the action of near-field underwater explosion.
Multi-strategy Improved Sparrow Search Algorithm
Authors: Liu Zichang , Bai Yongsheng , Jia Xisheng 
Published: July 2023

Abstract
The multi-strategy improved sparrow search algorithm (MSISSA) is proposed to address the problems that the sparrow search algorithm (SSA) is not rich in population diversity, and is prone to fall into local optimality and poor accuracy in solving multi-dimensional functions. Firstly, Cat mapping is used to initialize the SSA population. Secondly, an elite reverse learning strategy is introduced to increase the population diversity and improve the global search ability of SSA. Then, the number of discoverers and the number of aware-at-risk sparrows are dynamically adjusted by improving the scaling factor. Finally, individuals are subjected to Cauchy variation or Tent chaos perturbation according to their fitness values to effectively solve the problem of their falling into local optimality. Simulation results show that MSISSA has higher performance in finding the optimum compared with classical optimization algorithms such as SSA.