bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENDAMPINGAN PEMBELAJARAN BAHASA INGGRIS MELALUI PUBLIC SPEAKING DI SMA NEGERI 2 KOTA AGUNG
Authors: Hamzah Intan 
Published: September 2023

AbstrakKemampuan berbicara juga dapat menjadikan seseorang menjadi pemimpin karena public speaking merupakan komunikasi secara lisan tentang suatutopik dihadapan orang yang bertujuan untuk mempengaruhi, mendidik, memberi penjelasan serta memberi informasi kepada orang lain agar orang tersebut tertarik dengan apa yang kita sampaikan. Pengabdian kepada Masyarakat yang dilakukan di SMAN 2 Kota Agung yang memiliki tujuan untuk mendampingi para siswa-siswi untuk memiliki Public Speaking yang baik. Ada tiga sesi dalam kegiatan pengabdian ini, yaitu: 1) penyampaian materi mengenai Public Speaking, 2) Story telling dan praktik, 3) Speech dan praktik. Keterlibatan para siswa dalam proses pembelajaran Public Speaking ini pada akhirnya dapat meningkatkan rasa percaya diri siswa dalam berbicara Bahasa Inggris dan menurunkan persepsi negatifnya terhadap Bahasa Inggris. Lebih lanjut, kegiatan ini diharapkan dapat dilakukan secara berkelanjutan di masa yang akan datang sehingga dapat tercapai tujuan pembelajaran Bahasa Inggris secara holistik. Kata kunci: bahasa inggris, public speaking, speech, story telling
STUDI EKSPERIMEN VARIASI JENIS SERAT DAN FRAKSI VOLUME KOMPOSIT BERMATRIKS UNSATURATED POLYMER RESIN (UPR) TERHADAP SIFAT MEKANIK DAN SIFAT FISIS MATERIAL
Authors: Indrayani Novi Laura , Rahmanto R. Hengki , Paridawati Paridawati , Maulana Hudan , Dayana Dio Nanda 
Published: September 2023

Abstrak
Biokomposit merupakan jenis material yang berasal dari bahan dasar organik dan akan lebih mudah terurai saat menjadi limbah. Banyak produk saat ini bersumber dari komposit, dengan adanya biokomposit tentu saja akan mengurangi jumlah limbah. Pada penelitian ini akan dibuat material biokomposit dengan 2 variasi jenis serat bermatriks Unsaturated Polymer Resin (UPR) dan fraksi volume. Serat yang digunakan antara lain serat ijuk pohon aren dan serat pandan laut. Biokomposit dibuat menjadi empat jenis spesimen dengan perbedaan fraksi volume yakni 5%serat dengan 95%matriks; 10%serat dengan 90%matriks; 15%serat dengan 85%matriks; dan 20%serat dengan 80%matriks dengan metode hand lay – up. Hasil pembuatan biokomposit dilakukan pengujian sifat fisis berupa pengujian densitas, daya serap air dan swelling dan pengujian mekanik dengan uji tarik dan uji impact. Nilai sifat fisis terlihat hampir sama untuk masing-masing serat. Sedangkan untuk sifat mekanik biokomposit serat ijuk menunjukkan kekuatan impact tertinggi dibandingkan serat lainnya, diperoleh pada fraksi volume serat KSI3 yaitu sebesar 30,860 kJ/m2. Pada nilai kuat tarik biokomposit serat ijuk juga dapat menerima tegangan sampai menghasilkan nilai deformasinya sebesar 25,73 MPa.
Kata Kunci: Biokomposit serat, fraksi volume, metode hand lay – up, unsaturated polyester resin, uji sifat mekanik, uji sifat fisis.
Abstract
Biocomposite is a type of material derived from organic base materials and will more easily decompose when it becomes waste. Many products are currently sourced from composites, with the presence of biocomposites of course it will reduce the amount of waste. In this research, biocomposite materials will be made with 2 variations of Unsaturated Polymer Resin (UPR) fiber matrix types and volume fractions. The fibers used include palm fiber fibers and sea pandan fibers. The biocomposite was made into four types of specimens with different volume fractions, namely 5% fiber and 95% matrix; 10% fiber with 90% matrix; 15% fiber with 85% matrix; and 20% fiber with 80% matrix by hand lay-up method. The results of the manufacture of biocomposites were tested for physical properties in the form of testing density, water absorption and thickness expansion and mechanical testing with tensile and impact tests. The value of physical properties looks almost the same for each fiber. As for the mechanical properties of the palm fiber biocomposite, it showed the highest impact strength compared to other fibers, obtained in the volume fraction of KSI3 fiber, which was 30.860 kJ/m2. On the tensile strength value of the palm fiber biocomposite can also accept stress to produce a deformation value of 25.73 MPa.
Keywords: Fiber biocomposite, volume fraction, hand lay-up method, unsaturated polyester resin, mechanical properties test, physical properties test.
Effects of different habitual foot strike patterns on in vivo kinematics of the first metatarsophalangeal joint during shod running—a statistical parametric mapping study
Authors: Wu Kaicheng , Sun Xiaole , Ye Dongqiang , Zhang Faning , Zhang Shen , Fu Weijie 
Published: September 2023

Existing studies on the biomechanical characteristics of the first metatarsophalangeal joint (1st MTPJ) during shod running are limited to sagittal plane assessment and rely on skin marker motion capture, which can be affected by shoes wrapping around the 1st MTPJ and may lead to inaccurate results. This study aims to investigate the in vivo effects of different habitual foot strike patterns (FSP) on the six degrees of freedom (6DOF) values of the 1st MTPJ under shod condition by utilizing a dual-fluoroscopic imaging system (DFIS). Long-distance male runners with habitual forefoot strike (FFS group, n = 15) and rearfoot strike (RFS group, n = 15) patterns were recruited. All participants underwent foot computed tomography (CT) scan to generate 3D models of their foot. The 6DOF kinematics of the 1st MTPJ were collected using a DFIS at 100 Hz when participants performed their habitual FSP under shod conditions. Independent t-tests and one-dimensional statistical parametric mapping (1-d SPM) were employed to analyze the differences between the FFS and RFS groups’ 1st MTPJ 6DOF kinematic values during the stance phase. FFS exhibited greater superior translation (3.5–4.9 mm, p = 0.07) during 51%–82% of the stance and higher extension angle (8.4°–10.1°, p = 0.031) during 65%–75% of the stance in the 1st MTPJ than RFS. Meanwhile, FFS exhibited greater maximum superior translation (+3.2 mm, p = 0.022), maximum valgus angle (+6.1°, p = 0.048) and varus–valgus range of motion (ROM) (+6.5°, p = 0.005) in the 1st MTPJ during stance. The greater extension angle of the 1st MTPJ in the late stance suggested that running with FFS may enhance the propulsive effect. However, the higher maximum valgus angle and the ROM of varus–valgus in FFS may potentially lead to the development of hallux valgus.
Role of ferroptosis and immune infiltration in intervertebral disc degeneration: novel insights from bioinformatics analyses
Authors: Liu Xiao-Wei , Xu Hao-Wei , Yi Yu-Yang , Zhang Shu-Bao , Wang Shan-Jin 
Published: September 2023

Background: Intervertebral disc degeneration (IVDD), which contributes to stenosis of the spinal segment, commonly causes lower back pain. The process of IVDD degradation entails gradual structural adjustments accompanied by extreme transformations in metabolic homeostasis. However, the molecular and cellular mechanisms associated with IVDD are poorly understood.Methods: The RNA-sequencing datasets GSE34095 and GSE56081 were obtained from the Gene Expression Omnibus (GEO) database. Ferroptosis-related differentially expressed genes (DEGs) were identified from these gene sets. The protein–protein interaction (PPI) network was established and visualized using the STRING database and Cytoscape software, and the key functional modules of ferroptosis-related genes were identified. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed on the DEGs. Weighted gene co-expression network analysis (WGCNA), immune infiltration analysis in the GEO database, and other GSE series were used as validation datasets. The xCELL algorithm was performed to investigate the immune cell infiltration differences between the degenerated IVDD and control groups.Results: The major genes involved in nucleus pulposus tissue immune infiltration and ferroptosis-related genes were mined by bioinformatics analysis. A total of 3,056 DEGs were obtained between the IVDD tissue and control groups. The DEGs were enriched in the cell cycle; apoptosis; necroptosis; and the PI3K-Akt, Hippo, and HIF-1 signaling pathways. PCR and Western blot techniques were utilized to confirm the differential ferroptosis-related genes. The results indicated that the protein expression levels of NCOA4 and PCBP1 were elevated, while the protein expression level of GPX4 was reduced in NPCs following IL-1β treatment. Our study has found that severe disc tissue degeneration leads to a noteworthy increase in the expression of CD8A in naive T cells, CCR7 in memory CD4+ cells, GZMB in natural killer (NK) cells, and CD163 and CD45 in macrophages.Conclusion: Our data demonstrate that ferroptosis occurs in IVDD, suggesting that ferroptosis may also increase IVDD improvement by triggering immune infiltration. This work was conducted to further understand IVDD pathogenesis and identify new treatment strategies.
Bioinformatics-based analysis reveals elevated CYTL1 as a potential therapeutic target for BRAF-mutated melanoma
Authors: Tao Lei , Cui Yingyue , Sun Jiarui , Cao Yu , Dai Zhen , Ge Xiaoming , Zhang Ling , Ma Run , Liu Yunyao 
Published: September 2023

Introduction: Despite many recent emerging therapeutic modalities that have prolonged the survival of melanoma patients, the prognosis of melanoma remains discouraging, and further understanding of the mechanisms underlying melanoma progression is needed. Melanoma patients often have multiple genetic mutations, with BRAF mutations being the most common. In this study, public databases were exploited to explore a potential therapeutic target for BRAF-mutated melanoma.Methods: In this study, we analyzed differentially expressed genes (DEGs) in normal tissues and melanomas, Braf wild-type and Braf mutant melanomas using information from TCGA databases and the GEO database. Subsequently, we analyzed the differential expression of CYTL1 in various tumor tissues and its effect on melanoma prognosis, and resolved the mutation status of CYTL1 and its related signalling pathways. By knocking down CYTL1 in melanoma cells, the effects of CYTL1 on melanoma cell proliferation, migration and invasion were further examined by CCK8 assay, Transwell assay and cell migration assay.Results: 24 overlapping genes were identified by analyzing DEGs common to melanoma and normal tissue, BRAF-mutated and BRAF wild-type melanoma. Among them, CYTL1 was highly expressed in melanoma, especially in BRAF-mutated melanoma, and the high expression of CYTL1 was associated with epithelial-mesenchymal transition (EMT), cell cycle, and cellular response to UV. In melanoma patients, especially BRAF-mutated melanoma patients, clinical studies showed a positive correlation between increased CYTL1 expression and shorter overall survival (OS) and disease-free survival (DFS). In vitro experiments further confirmed that the knockdown of CYTL1 significantly inhibited the migration and invasive ability of melanoma cells.Conclusion: CYTL1 is a valuable prognostic biomarker and a potentially effective therapeutic target in melanoma, especially BRAF-mutated melanoma.
Lower gut abundance of Eubacterium rectale is linked to COVID-19 mortality
Authors: Liu Yingzhi , Chan Matthew T. V. , Chan Francis K. L. , Wu William K. K. , Ng Siew C. , Zhang Lin 
Published: September 2023

IntroductionEmerging preclinical and clinical studies suggest that altered gut microbiome composition and functions are associated with coronavirus 2019 (COVID- 19) severity and its long-term complications. We hypothesize that COVID-19 outcome is associated with gut microbiome status in population-based settings.MethodsGut metagenomic data of the adult population consisting of 2871 subjects from 16 countries were obtained from ExperimentHub through R, while the dynamic death data of COVID-19 patients between January 22, 2020 and December 8, 2020 in each country was acquired from Johns Hopkins Coronavirus Resource Center. An adjusted stable mortality rate (SMR) was used to represent these countries’ mortality and correlated with the mean relative abundance (mRA) of healthy adult gut microbiome species.ResultsAfter excluding bacterial species with low prevalence (prevalence &lt;0.2 in the included countries), the β-diversity was significantly higher in the countries with high SMR when compared with those with median or low SMR (p &lt;0.001). We then identified the mRA of two butyrate producers, Eubacterium rectale and Roseburia intestinalis, that were negatively correlated with SMR during the study period. And the reduction of these species was associated with severer COVID-19 manifestation.ConclusionPopulation-based microbiome signatures with the stable mortality rate of COVID-19 in different countries suggest that altered gut microbiome composition and functions are associated with mortality of COVID-19.
Surgical treatment of left-sided infective endocarditis with symptomatic neurological complications before surgery in China
Authors: Huang Jing-bin , Lu Chang-chao , Wen Zhao-ke , Yang Jian-rong , Li Jun-jun 
Published: September 2023

IntroductionWe aimed to investigate surgical treatment of left-sided infective endocarditis with symptomatic neurological complications before surgery.MethodsThis was a retrospective study of patients with left-sided infective endocarditis and symptomatic neurological complications before surgery undergoing cardiac surgery between January 2006 and November 2022 at our hospital.ResultsEight hundred thirty-two patients were divided into group with symptomatic neurological complications before surgery (n = 112) and without symptomatic neurological complications before surgery (n = 720). There were 48 operative deaths (5.4%). Univariate and multivariate analyses showed that symptomatic neurological complications before surgery is statistically significantly associated with in-hospital mortality following cardiac surgery and prolonged intubation time.ConclusionsOur study showed that symptomatic neurological complications before surgery are associated with increased in-hospital mortality following cardiac surgery and prolonged intubation time.
A combination of strongly associated prothrombotic single nucleotide polymorphisms could efficiently predict venous thrombosis risk
Authors: Natae Shewaye Fituma , Merzah Mohammed Abdulridha , Sándor János , Ádány Róza , Bereczky Zsuzsanna , Fiatal Szilvia 
Published: September 2023

BackgroundVenous thrombosis (VT) is multifactorial trait that contributes to the global burden of cardiovascular diseases. Although abundant single nucleotide polymorphisms (SNPs) provoke the susceptibility of an individual to VT, research has found that the five most strongly associated SNPs, namely, rs6025 (F5 Leiden), rs2066865 (FGG), rs2036914 (F11), rs8176719 (ABO), and rs1799963 (F2), play the greatest role. Association and risk prediction models are rarely established by using merely the five strongly associated SNPs. This study aims to explore the combined VT risk predictability of the five SNPs and well-known non-genetic VT risk factors such as aging and obesity in the Hungarian population.MethodsSNPs were genotyped in the VT group (n = 298) and control group (n = 400). Associations were established using standard genetic models. Genetic risk scores (GRS) [unweighted GRS (unGRS), weighted GRS (wGRS)] were also computed. Correspondingly, the areas under the receiver operating characteristic curves (AUCs) for genetic and non-genetic risk factors were estimated to explore their VT risk predictability in the study population.Resultsrs6025 was the most prevalent VT risk allele in the Hungarian population. Its risk allele frequency was 3.52-fold higher in the VT group than that in the control group [adjusted odds ratio (AOR) = 3.52, 95% CI: 2.50–4.95]. Using all genetic models, we found that rs6025 and rs2036914 remained significantly associated with VT risk after multiple correction testing was performed. However, rs8176719 remained statistically significant only in the multiplicative (AOR = 1.33, 95% CI: 1.07–1.64) and genotypic models (AOR = 1.77, 95% CI: 1.14–2.73). In addition, rs2066865 lost its significant association with VT risk after multiple correction testing was performed. Conversely, the prothrombin mutation (rs1799963) did not show any significant association. The AUC of Leiden mutation (rs6025) showed better discriminative accuracy than that of other SNPs (AUC = 0.62, 95% CI: 0.57–0.66). The wGRS was a better predictor for VT than the unGRS (AUC = 0.67 vs. 0.65). Furthermore, combining genetic and non-genetic VT risk factors significantly increased the AUC to 0.89 with statistically significant differences (Z = 3.924, p &lt; 0.0001).ConclusionsOur study revealed that the five strongly associated SNPs combined with non-genetic factors could efficiently predict individual VT risk susceptibility. The combined model was the best predictor of VT risk, so stratifying high-risk individuals based on their genetic profiling and well-known non-modifiable VT risk factors was important for the effective and efficient utilization of VT risk preventive and control measures. Furthermore, we urged further study that compares the VT risk predictability in the Hungarian population using the formerly discovered VT SNPs with the novel strongly associated VT SNPs.
Development of SkinTracker, an integrated dermatology mobile app and web portal enabling remote clinical research studies
Authors: Jin Joy Q. , Hong Julie , Elhage Kareem G. , Braun Mitchell , Spencer Riley K. , Chung Mimi , Yeroushalmi Samuel , Hadeler Edward , Mosca Megan , Bartholomew Erin , Hakimi Marwa , Davis Mitchell S. , Thibodeaux Quinn , Wu David , Kahlon Abhilash , Dhaliwal Paul , Mathes Erin F. , Dhaliwal Navdeep , Bhutani Tina , Liao Wilson 
Published: September 2023

IntroductionIn-person dermatology clinical research studies often face recruitment and participation challenges due to travel-, time-, and cost-associated barriers. Studies incorporating virtual/asynchronous formats can potentially enhance research subject participation and satisfaction, but few mobile health tools are available to enable remote study conduct. We developed SkinTracker, a patient-facing mobile app and researcher-facing web platform, that enables longitudinal collection of skin photos, patient reported outcomes, and biometric health and environmental data.MethodsEight design thinking sessions including dermatologists, clinical research staff, software engineers, and graphic designers were held to create the components of SkinTracker. Following iterative prototyping, SkinTracker was piloted across six adult and four pediatric subjects with atopic dermatitis (AD) of varying severity levels to test and provide feedback on SkinTracker for six months.ResultsThe SkinTracker app enables collection of informed consent for study participation, baseline medical history, standardized skin photographs, patient-reported outcomes (e.g., Patient Oriented Eczema Measure (POEM), Pruritus Numerical Rating Scale (NRS), Dermatology Life Quality Index (DLQI)), medication use, adverse events, voice diary to document qualitative experiences, chat function for communication with research team, environmental and biometric data such as exercise and sleep metrics through integration with an Apple Watch. The researcher web portal allows for management and visualization of subject enrollment, skin photographs for examination and severity scoring, survey completion, and other patient modules. The pilot study requested that subjects complete surveys and photographs on a weekly to monthly basis via the SkinTracker app. Afterwards, participants rated their experience in a 7-item user experience survey covering app function, design, and desire for participation in future studies using SkinTracker. Almost all subjects agreed or strongly agreed that SkinTracker enabled more convenient participation in skin research studies compared to an in-person format.DiscussionTo our knowledge, SkinTracker is one of the first integrated app- and web-based platforms allowing collection and management of data commonly obtained in clinical research studies. SkinTracker enables detailed, frequent capture of data that may better reflect the fluctuating course of conditions such as AD, and can be modularly customized for different skin conditions to improve dermatologic research participation and patient access.
Bridge to health informatics—a 5-week intensive online program to increase diversity in health informatics
Authors: Howard Angelita P. , Slaughter Liane Siu , Simmonds Consuela , McPherson Rebecca , Kennedy Nia , Bentley Keisha 
Published: September 2023

IntroductionHealth informatics (HI) has the potential to address health disparities and improve healthcare outcomes; however, lack of diversity in the workforce, especially at advanced levels, feeds disparities, and creates inequities. Increasing participation from underrepresented minorities requires exposure and connection to the field and career opportunities including advanced degrees. Morehouse School of Medicine (MSM) created the no-cost, 5-week intensive online Bridge to Health Informatics (B2HI) program in 2021 to connect participants from backgrounds underrepresented in HI with industry-relevant skills, professional certification, business experience, and graduate training opportunities.MethodsThe curriculum included intensive training in knowledge and current trends, business propositions, and professional certifications. Successful completion of the B2HI provided scholars with guaranteed admissions into the Master of Science in Health Informatics (MSHI) degree program, which premiered at MSM in August 2021. We deployed several strategies to attract individuals interested in advancing their careers in HI. To assess the impact of the recruitment strategy and program, we analyzed applicant demographics, the interests of those accepted into the program, and feedback from participants via anonymous online surveys.ResultsIn 2021, our recruitment efforts attracted 65 applications, over whom 90% self-identified as African American and the majority were working adults. Among the 46 applicants accepted and enrolled, 38 (83%) completed the program. Thirteen B2HI graduates enrolled in the first offerings (Fall 2021 and Spring 2022) of the online MSHI degree program, the highest number for the first sessions of our online master’s degree programs, indicating that B2HI connects scholars with advanced training. Participants indicated immense overall satisfaction with the program and had strong positive responses for increased interest and confidence to do advanced work in the subject.DiscussionThe data indicate that B2HI addresses key factors that hinder diversity in healthcare and informatics-related fields, including awareness, access, and social support, and connect students with the next stages of training toward careers that require an advanced degree. By providing opportunity, resources, and networks that help participants raise their potential to become leaders and decision-makers in the healthcare industry, programs like B2HI enable the collective effort to decrease health disparities.