bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erxian Decoction Enhances the Tamoxifen Sensitivity in Luminal Breast Cancer through the PI3K‐AKT Signaling Pathway
Authors: Wang Xinbin , Zhang Zhongwen , Wang Haorui , Ma Ruiling , Zhang Yi , Wang Rong 
Published: July 2023

AbstractBackground: The primary and secondary resistance of luminal breast cancer (LBC) against endocrine therapy is a serious clinical problem. At present, it has been confirmed that Erxian Decoction can improve the sensitivity of LBC to tamoxifen (TAM), but its mechanism is not clear. The purpose of this paper is to explore the molecular mechanism that causes Erxian Decoction to increase the sensitivity of LBC to TAM.Methods: The potential targets and related pathways of Erxian Decoction inhibiting LBC were screened through bioinformatics. The small molecular compounds that could stably bind to LBC targets were determined by molecular docking. The stable interaction of the target and the small molecular compounds was revealed by the cell thermal shift assay (CETSA). Cell Counting Kit‐8 (CCK‐8) was used to verify the effect of Erxian Decoction and TAM on the cell activity of LBC. Flow cytometry was used to verify the effect of Erxian Decoction and TAM on the apoptosis of LBC cells. Western blot was used to detect the expression of PI3K‐AKT pathway‐related proteins in cells.Results: ERBB2 was screened as a potential target for the treatment of LBC. Based on molecular docking and CETSA results, the stable interaction between luteolin and ERBB2 was confirmed. CCK‐8 results showed that luteolin could inhibit the cell activity of LBC, and luteolin treatment could improve the drug sensitivity of tumor cells to TAM. The results of flow cytometry showed that compared with TAM treatment alone, the addition of luteolin trefatment promoted the apoptosis level of LBC cells. Western blot results indicated that luteolin could inhibit the PI3K‐AKT signal pathway by combining with ERBB2.Conclusion: Luteolin in Erxian Decoction inhibited the progression of LBC and enhanced the sensitivity of LBC to TAM by binding with ERBB2 to down‐regulate the activity of the PI3K‐AKT signaling pathway. This study provided theoretical support for endocrine therapy of TAM‐resistant LBC patients.
Functionalization of Poly (1‐hexene) with Maleic Anhydride: The Effect of Reaction Parameters
Authors: Reza Zamani Mohammad , Khoshsefat Mostafa , Ahmadjo Saeid , Mohammad Seyed , Mortazavi Mahdi , Reza Rostami Mohammad 
Published: July 2023

AbstractThe functionalization of poly (1‐hexene) with maleic anhydride (MA) in the presence of benzoyl peroxide as initiator was investigated and the effect of reaction parameters such as initiator content, maleic anhydride concentrations, reaction temperature and reaction time were studied. Furthermore, changing the catalyst system from a commercial Ziegler‐Natta (TiCl4/MgCl2/Internal donor) to α‐diimine Nickel catalyst led to a higher degree of functionalization (DOF) thanks to higher unsaturation content of polymer chains made by the Nickel catalyst system. The obtained polymer moreover was contacted with polyethylene glycol methyl ether to ensure the attachment of the functionalizing agent on the poly (1‐hexene) chains. Different analyses were used to support the observations. For instance, thermogravimetric analysis (TGA) exhibited no weight loss at 210 °C for the sample confirming, the complete reaction of maleic anhydride, or FTIR analysis, where the presence of ester group bands was evidence for the reaction.
Synthesis of Bridged N,O‐Heterocyclic 1,6‐Epoxybenzo[c]azocines via Migration‐Annulation Cascade Reaction of α‐Imino Rhodium Carbenes
Authors: Kong Xiaoyu , Yang Mingqi , Wang Heng , Xu Ze‐Feng , Duan Shengguo , Li Chuan‐Ying 
Published: July 2023

AbstractA rhodium‐catalyzed cascade migration‐annulation reaction of 1‐sulfonyl‐1,2,3‐triazole has been developed. As the key step, the 1,3‐sulfinate migration of α‐imino rhodium carbene yielded an extended zwitterion, which was intramolecularly trapped by aldehyde group furnishing bridged N,O‐heterocyclic 1,6‐epoxybenzo[c]azocine as the [5+2] cyclization product. This migration‐annulation strategy provides more flexibility for heterocycle synthesis and medium‐sized ring construction, especially for the construction of polycycles with complex skeletons.
Computational Exploration of the Structural Requirements of Triazole Derivatives as Colchicine Binding Site Inhibitors
Authors: Tabti Kamal , Sbai Abdelouahid , Maghat Hamid , Lakhlifi Tahar , Bouachrine Mohammed 
Published: July 2023

AbstractColchicine inhibits microtubule assembly by preventing tubulin polymerization, making the colchicine binding site a promising target against cancer. The present study focuses on the 3D‐QSAR analysis of 31 triazole analogs. The atom‐based and field‐based QSAR models exhibit significant statistical results for internal and external validations, with the atom‐based 3D‐QSAR model showing a Q2 of 0.658 and R2 of 0.998, and the field‐based 3D‐QSAR model showing a Q2 of 0.658 and R2 of 0.998. The 3D‐QSAR atom‐based pharmacophore model explains biological activity using a six‐point hypothesis (AHHRRR.1), while the field‐based 3D‐QSAR model explains activity based on steric, electrostatic, hydrophobic, and hydrogen bond donor/acceptor fields. Based on the 3D contour maps generated, five new compounds were designed and their ADME/Tox properties predicted. The results suggested that these compounds possess potent pharmacological characteristics. The results of the molecular docking analysis showed that Pred01 and Pred02 had higher docking scores (−6.2417Kcal/mol and −6.5049Kcal/mol, respectively) than compound 15, and they formed notable hydrogen bonds and hydrophobic interactions with active site residues. The MMGBSA results confirmed these findings and emphasized the essential role of van der Waals energy in the binding energy. Moreover, the dynamic stability of the complexes was further supported by MD simulations.
1,2‐Dioxetane‐based Chemiluminescence Probes for Tumor Optical Molecular Imaging
Authors: Zhou Bingjun , Xian Meilin , Ye Lu , Tang Weiyang , Zhou Jian‐Liang 
Published: July 2023

Abstract1,2‐Dioxetane‐based chemiluminescent probes have recently emerged as a promising tool for imaging biological systems, including disease diagnosis, staging, therapeutic response monitoring and surgical guidance. The advantages of these probes, such as high sensitivity and specificity and real‐time imaging capabilities, are based on their ability to generate chemiluminescent signals without the need for additional excitation sources, enzymes or oxidants after being triggered by target biomarkers under physiological conditions. Over the past decade, numerous 1,2‐dioxetane‐based chemiluminescent probes have been developed and tested for tumor imaging. In this review, we first introduce the trigger mechanism and structural improvements of these probes, followed by an overview of the design principles and applications of 1,2‐dioxetane‐based chemiluminescent probes in in vrtio and in vivo tumour imaging. In addition, the challenges and potential prospects of this technology in the field of bioanalysis and diagnostics are discussed, with the aim of stimulating further progress in the development of new chemiluminescence methods.
Correlation Between Orientation of the Stacked π‐Electron Systems and Chiroptical Properties
Authors: Ogawa Kana , Miki Nanami , Inoue Ryo , Morisaki Yasuhiro 
Published: July 2023

AbstractThe correlation between the orientation of the two π‐electron systems and the chiroptical properties was investigated using two types of optically active X‐shaped molecules consisting of planar chiral [2.2]paracyclophanes. The X‐shaped molecules exhibited high photoluminescence quantum efficiencies and good circularly polarized luminescence properties with relatively high anisotropy factors of the order of 10−3. It was experimentally and theoretically elucidated that the chiroptical properties of the two molecules were almost identical, regardless of the orientation of the stacked π‐electron systems.
Microwell Confined Electro‐Coalescence for Rapid Formation of High‐Throughput Droplet Array
Authors: Feng Haoqiang , Shen Shitao , Jin Mingliang , Zhang Qilin , Liu Mengjun , Wu Zihao , Chen Jiamei , Yi Zichuan , Zhou Guofu , Shui Lingling 
Published: July 2023

AbstractDroplet array is widely applied in single cell analysis, drug screening, protein crystallization, etc. This work proposes and validates a method for rapid formation of uniform droplet array based on microwell confined droplets electro‐coalescence of screen‐printed emulsion droplets, namely electro‐coalescence droplet array (ECDA). The electro‐coalescence of droplets is according to the polarization induced electrostatic and dielectrophoretic forces, and the dielectrowetting effect. The photolithographically fabricated microwells are highly regular and reproducible, ensuring identical volume and physical confinement to achieve uniform droplet array, and meanwhile the microwell isolation protects the paired water droplets from further fusion and broadens its feasibility to different fluidic systems. Under optimized conditions, a droplet array with an average diameter of 85 µm and a throughput of 106 in a 10 cm × 10 cm chip can be achieved within 5 s at 120 Vpp and 50 kHz. This ECDA chip is validated for various microwell geometries and functional materials. The optimized ECDA are successfully applied for digital viable bacteria counting, showing comparable results to the plate culture counting. Such an ECDA chip, as a digitizable and high‐throughput platform, presents excellent potential for high‐throughput screening, analysis, absolute quantification, etc.
Better engineering layered vanadium oxides for aqueous zinc‐ion batteries: Going beyond widening the interlayer spacing
Authors: Guo Yue , Jiang Hanmei , Liu Binbin , Wang Xingyang , Zhang Yifu , Sun Jianguo , Wang John 
Published: July 2023

AbstractAqueous zinc‐ion batteries (ZIBs) are regarded as among the most promising candidates for large‐scale grid energy storage, owing to their high safety, low costs, and environmental friendliness. Over the past decade, vanadium oxides, which are exemplified by V2O5, have been widely developed as a class of cathode materials for ZIBs, where the relatively high theoretical capacity and structural stability are among the main considerations. However, there are considerable challenges in the construction of vanadium‐based ZIBs with high capacity, long lifespan, and excellent rate performance. Simple widenings of the interlayer spacing in the layered vanadium oxides by pre‐intercalations appear to have reached their limitations in improving the energy density and other key performance parameters of ZIBs, although various metal ions (Na+, Ca2+, and Al3+) and even organic cations/groups have been explored. Herein, we discuss the advances made more recently, and also the challenges faced by the high‐performance vanadium oxides (V2O5‐based) cathodes, where there are several strategies to improve their electrochemical performance ranging from the new structural designs down to sub‐nano‐scopic/molecular/atomic levels, including cation pre‐intercalation, structural water optimization, and defect engineering, to macroscopic structural modifications. The key principles for an optimal structural design of the V2O5‐based cathode materials for high energy density and fast‐charging aqueous ZIBs are examined, aiming at paving the way for developing energy storage designed for those large scales, high safety, and low‐cost systems.
Iontronic and electrochemical investigations of 2D tellurene in aqueous electrolytes
Authors: Wu Zongxiao , Qi Junlei , Wang Wenbin , Yang Peng , Ma Chen , Huang Haoxin , Bao Kai , Wu Jingkun , Ke Chengxuan , Chen Ye , Tan Chaoliang , Repaka D. V. Maheswar , He Qiyuan 
Published: July 2023

AbstractThe remarkable successes of graphene have sparked increasing interest in elemental two‐dimensional (2D) materials, also referred to as Xenes. Due to their chemical simplicity and appealing physiochemical properties, Xenes have shown particular potential for numerous (opto) electronic, iontronic, and energy applications. Among them, layered α‐phase tellurene has demonstrated the most promise, thanks to the recent successes in the chemical synthesis of highly crystalline 2D tellurene. However, the general electronic and electrochemical properties of tellurene in electrolyte systems remain ambiguous, hindering their further development. In this work, we studied the electrostatic gating, electrocatalysis, and electrochemical stability of tellurene in electrolyte systems. Our results show that tellurene obtained from both hydrothermal and chemical vapor deposition methods, two mainstream synthetic approaches for Xenes, demonstrates thickness‐dependent ambipolar transport with high hole mobility and stability in both aqueous electrolytes and ionic liquids. More importantly, the electrochemical properties of tellurene are investigated via the emerging on‐chip electrochemistry. Pristine tellurene demonstrates hydrogen evolution reaction with low Tafel slopes and remarkable electrochemical stability in acidic electrolytes over a large potential window. Our study provides a comprehensive understanding of the iontronic and electrochemical properties of tellurene, paving the way for the broad adoption of Xenes in sensors, synaptic devices, and electrocatalysis.
Connected by emotion: Teacher agency in an online science education course during COVID‐19
Authors: Fu Guopeng , Clarke Anthony 
Published: July 2023

AbstractTaking on an agentic perspective, this study employed a digital ethnographic approach to examine a science teacher's emotional experiences in an online graduate science education course during the COVID‐19 pandemic. Veronika, the teacher, revealed her feelings of grievance and loss to the graduate course cohort at the advent of large‐scale school closures. Her emotions, shared through the online course, connected the members of the cohort to overcome emotional and pedagogical difficulties caused by the pandemic. She received both emotional and professional support from the cohort and designed an environmental related learning activity that centered on fun and connection in science learning. The activity stimulated students’ positive emotions and simultaneously served to reset Veronika's emotions. This study underlined that emotions connect teachers during a social crisis in ways that address obstacles encountered in teaching and learning. Lessons for teacher education include providing space for and acknowledging emotions in teaching, especially in times of stress and the importance of fostering agentic actions, collegiality, and collaboration by explicitly connecting an individual's emotions and beliefs to their professional practice.
Exposure of zebrafish (Danio rerio) to graphene oxide for 6 months suppressed NOD‐like receptor‐regulated anti‐virus signaling pathways
Authors: Wei Lianghuan , Liu Tingna , Liu Jincheng , Lin Yingchao , Cao Yi 
Published: July 2023

AbstractEnvironmental exposure to graphene oxide (GO) is likely to happen due to the use and disposal of these materials. Although GO‐induced ecological toxicity has been evaluated before by using aquatic models such as zebrafish, previous studies typically focused on the short‐term toxicity, whereas this study aimed to investigate the long‐term toxicity. To this end, we exposed zebrafish to GO for 6 months, and used RNA‐sequencing to reveal the changes of signaling pathways. While GO exposure showed no significant effects on locomotor activities, it induced histological changes in livers. RNA‐sequencing data showed that GO altered gene expression profiles, resulting in 82 up‐regulated and 275 down‐regulated genes, respectively. Through the analysis of gene ontology terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, we found that GO suppressed the signaling pathways related with immune systems. We further verified that GO exposure suppressed the expression of genes involved in anti‐virus responses possibly through the inhibition of genes involved in NOD‐like receptor signaling pathway. Furthermore, NOD‐like receptor‐regulated lipid genes were also inhibited, which may consequently lead to decreased lipid staining in fish muscles. We concluded that 6 month‐exposure to GO suppressed NOD‐like receptor‐regulated anti‐virus signaling pathways in zebrafish.
Epidural analgesia and emergency delivery for presumed fetal compromise: post‐hoc analysis of RAVEL multicenter randomized controlled trial
Authors: Tabernée Heijtmeijer E. S. E. , Groen H. , Damhuis S. E. , Freeman L. M. , Middeldorp J. M. , Ganzevoort W. , Gordijn S. J. 
Published: July 2023

ABSTRACTObjectiveTo investigate the association between epidural analgesia (EDA) vs patient‐controlled remifentanil analgesia (PCRA) and emergency delivery for presumed fetal compromise, in relation to birth‐weight quintile.MethodsThis was a post‐hoc per‐protocol analysis of the RAVEL multicenter equivalence randomized controlled trial. Non‐anomalous singleton pregnancies between 36 + 0 and 42 + 6 weeks' gestation were randomized at the time of requesting pain relief to receive EDA or PCRA. The primary outcome was emergency delivery for presumed fetal compromise. Secondary outcomes included mode of delivery and neonatal outcomes. Analysis was performed according to birth‐weight quintile and was corrected for relevant confounding variables.ResultsOf 619 pregnant women, 336 received PCRA and 283 received EDA. Among women receiving EDA, 14.8% had an emergency delivery for presumed fetal compromise, compared with 8.3% of women who received PCRA. After adjusting for parity, women receiving EDA had higher odds of presumed fetal compromise compared to those receiving PCRA (odds ratio, 1.69 (95% CI, 1.01–2.83)). A statistically significant linear‐by‐linear association was observed between presumed fetal compromise and birth‐weight quintile (P = 0.003). The incidence of emergency delivery for presumed fetal compromise was highest in women receiving EDA and delivering a neonate with a birth weight in the lowest quintile.ConclusionsIntrapartum EDA is associated with a higher rate of emergency delivery for presumed fetal compromise compared to treatment with PCRA. Birth‐weight quintile is a strong predictor of this outcome, independent of pain management method. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Methods and Limits of Data-Based Decision Support in Production Management
Authors: Kiesel R. , Gützlaff Andreas , Schmitt R. H. , Schuh G. 
Published: July 2023

AbstractThe volatility of today’s markets is constantly rising due to, i.e., the rapid emergence of new and innovative competitors, changing government policies, and unknown market acceptance. This affects both short-term and long-term production management. While short-term production management must deal with a higher time sensitivity of decisions, long-term production management must deal with an increasing level of uncertainty in decisions. Thus, to stay competitive in the future, short-term production management must especially increase the implementation speed of decision, whereas long-term production management focuses on the improvement of decision quality in uncertain environments. Therefore, the Internet of Production (IoP) develops data-based decision support methods for both short-term and long-term production management, which are presented in this chapter. For short-term production management, data-based decision support methods are presented for quality control loops, production planning and control, as well as production system configuration. For long-term production management, methods are presented for factory planning, global supply chain management, and production network planning.
A Project by Young People for Young People: The European Youth Week 2019 in Kielce
Authors: Habelt Katharina , Despang Jennifer 
Published: July 2023

AbstractThis chapter reports about the Erasmus+ funded project European Youth Week 2019, which was conducted in Kielce, Poland, by the Regional Volunteer Centre. The overarching goals of the project were to start a dialogue between people, decision makers and the young people in the town, as well as to promote the project Erasmus+ and a youth policy. To this end, young people independently organised the project and held debates on local issues with decision makers and peers. Based on an analysis of the planning, process and outcomes of the project, the chapter concludes that even though there were no visible policy changes, an indirect and sustainable empowerment of the youth can be observed. It also identifies important success factors for similar projects, such as flexibility.
Making Young People in Remote Rural Areas Heard: (un)Attractive? II
Authors: Kónya Gergö 
Published: July 2023

AbstractThis chapter summarises the experiences of the Hungarian Federation of the Children’s and Youth Municipal Councils with its Erasmus funded project (un)Attractive? II. The overarching question is how the EU can reach out to the youth in the rural areas of Hungary. The chapter reports on the context conditions, process, outcomes, challenges and success factors. Its key finding is that a basic approach towards youth work in the Hungarian rural areas is essential for the EU to reach this target group. It also reveals that youth work requires flexibility, an unbiased approach and an adaptable program since the conditions for organising youth projects vary strongly across the regions within Hungary. While EU funding is much needed, the municipalities’ involvement and commitment are also crucial for the long-term success of comparable projects.
How to Enhance EU Citizenship in the Rural Areas of East Central Europe: Recommendations for Governments and Regional Authorities
Authors: Lorenz Astrid 
Published: July 2023

AbstractThe European Union has established a Youth Strategy, aimed at including young people in EU policy-making and it has considerably increased the budget of Erasmus+ funding for youth exchange programmes and other projects. However, the EU does not have the competence to shape all policies relevant for the implementation of this strategy. This chapter gives five policy recommendations to governments and regional authorities in Poland, the Czech Republic, Slovakia, Hungary and Romania. The proposed measures seem suitable to support young people in these countries so that they can enjoy their formal rights and EU citizenship in an equal way irrespective of where they are living. The recommendations pay particular attention to macro-regional as well as sub-regional peculiarities. They are based on the JMCoE fieldwork findings regarding young people and youth projects in the region presented in the other chapters of this volume and on an analysis of additional data.
European Citizenship as an Invisible Anchor: Students’ EU Perceptions in Rural Peripheral Areas of the Czech Republic
Authors: Stangenberger Mathilde , Formánková Hana 
Published: July 2023

AbstractBased on four group discussions conducted in the towns of Sokolov and Chrudim, this chapter analyses how students in secondary and vocational schools in rural peripheral areas of the Czech Republic perceive their EU citizenship. It shows that they do not reflect on their EU citizenship in everyday life, but associate it with core rights such as the freedom of movement, peace and security. These rights are personally important to them, but largely taken for granted. EU citizenship can thus be understood as an invisible, but indispensable anchor in their life. In the view of the students, the salience of the EU elections is compromised by a tangible lack of factual information on European politics and the fact that EU topics are marginally discussed at schools. The students wish more discussions on the EU.