bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of Thoracoscopic-guided Multiple Paravertebral Block for Video-assisted Thoracoscopic Lobectomy Surgery A Randomized Blinded Controlled Study
Authors: Li Zhixiong , Lin Qingshui , Lin Liangqing , Wu Qinghua , Ke Pinhui , Chen Huan , Lin Chunlan , Yu Yaohua 
Published: September 2023

Abstract
Background
Paravertebral block (PVB) has been increasingly popular for postoperative analgesia. However, few studies estimated the efficacy and safety of multiple PVB using thoracoscope-assisted technique for intraoperative analgesia and postoperative pain management for video-assisted thoracoscopic lobectomy (VATS LOBECTOMY).
Methods
A total of 120 patients scheduled for VATS LOBECTOMY were randomly assigned into two groups, to either placebo group or PBV group in a 1:2 ratio. Thoracoscopic-guided multi-points PVB was carried out with 0.5% ropivacaine (PVB group) or 0.9% NaCl (placebo group) at the beginning and the end of the surgery. The primary endpoint was intraoperative opioid consumption.
Results
Intraoperative opioids consumption was significantly lower in PVB group (878.14 ± 98.37 vs. 1432.20 ± 383.53 for remifentanil; 123.83 ± 17.98 vs. 266.42 ± 41.97 for fentanyl). Postoperatively, significantly longer duration of first time PCIA usage, less times of analgesic pump pressing and less rescue analgetic consumption were observed in PVB group. VAS scores at rest and during exercising were significantly lower in PVB group at all time points within the first 48h after surgery. PVB group was also associated with significantly higher total QoR-40 scores and lower incidence of analgesia related adverse events.
Conclusions
Thoracoscopic-guided multiple PVB was simple and effective in controlling pain both intra- and postoperatively for VATS LOBECTOMY. It was also associated with absence of detrimental effects due to opioid overuse and benefits of the early resumption of activity and physical function recovery.
Utilizing the highly efficient bimetallic-organic framework (Fe, Cu)/carbon nanotubes composite for the heterogeneous Fenton-like process
Authors: Parsa Jalal Basiri , Tahmasebi Pouya , Jafari Farnaz 
Published: September 2023

Abstract
Bimetallic-organic framework (Fe, Cu)/carbon nanotubes as a novel heterogeneous catalyst prepared through a simple and efficient solvothermal method has been utilized in Fenton-like process for the degradation of acid orange 7 (AO7). The response surface methodology (RSM) based on the five-level central composite design (CCD) has been employed for investigation the interaction between four effective variables including pH, H2O2 concentration, catalyst dose and reaction time. The results of optimization revealed that maximum AO7 degradation efficiency (92.76%) was attained at the optimum conditions of pH=3.8, H2O2 concentration = 25 mM, reaction time=23 min and catalyst dose=237.5 mg L-1. Interestingly, it was found that in addition to the role of Fe and Cu species on the surface of Fe0.67Cu0.33(BDC)@CNT, the surface oxygen-functional groups on the CNT leads to faster Fe(III)/Fe(II) cycling and efficient performance over a wider pH range. Furthermore, five sequential cycles confirmed the reusability of Fe0.67Cu0.33(BDC)@CNT catalyst. The concluding remarks of this study provide beneficial results for developing and utilizing advanced MOF-based catalysts for efficient environmental remediation.
The discovery of self-compatibility in the 1EBN Solanum malmeanum (Solanaceae) reveals novel source of genetic variability for diploid potato breeding
Authors: Nicolao Rodrigo , Castro Caroline M. , Heiden Gustavo 
Published: September 2023

Abstract
F1 hybrid potato breeding at the diploid level requires the development of new inbred lines from self-compatible germplasm. This study was carried out to search for new sources of self-compatible diploid wild potatoes focusing on the 1EBN species Solanum malmeanum. Five diploid accessions from Embrapa potato genebank were screened to evaluate their reproductive behavior and check if the production of viable seeds when self-pollinated results from successful fertilizations or apomixis. Measurements of the pollen were taken, and pollen viability was evaluated. Five treatments based on controlled crosses assessed gametes compatibility; response to self-pollination; occurrence of parthenocarpy and/or apomixis; and tested the accessions for autogamy and allogamy. Pollen viability vary from 96% to 100%, with viable pollen size varying from 20 µm to 22 µm. Cross-pollinations confirmed that all accessions produced viable gametes and are allogamous, since pollen tube growth confirmed fertilization in treatments where seeds were set. No accession produced parthenocarpic fruit nor apomictic seeds. Four self-pollinated accessions were self-incompatible with no fruit and seeds set. Self-incompatibility was due to a pre-zygotic barrier confirmed by inhibited pollen tube growth at 1/3 style length in BRA 00183778-0 and 2/3 in BRA 00167071-0, BRA 00167093-4, and BRA 00183754-1. One self-pollinated accession (BRA 00183755-8) produced 3 fruits totalizing 51 seeds. The self-compatibility in this accession was confirmed based on the image record of pollen tubes reaching the ovules, thus rejecting apomixis, which also did not occur in control (non-manipulated bagged flowers) and emasculated bagged flowers. The 51 endogamic seeds obtained were sown, and 17 seedlings were obtained, from which 16 tuberized. Still, further investigations are needed to elucidate the mechanism responsible for the self-compatibility, such as S-locus inhibitor (Sli), malfunction of S-RNase or HT genes.
Unexpected failure of regional marine cloud brightening in a warmer world
Authors: Ricke Katharine , Wan Jessica , Chen Chih-Chieh (Jack) , Tilmes Simone , Luongo Matthew , Richter Jadwiga 
Published: September 2023

Abstract

Marine cloud brightening is a solar geoengineering1–3 proposal to cool atmospheric temperatures and reduce some impacts of climate change. To-date, modeling studies of solar geoengineering have primarily focused on large-scale schemes with objectives of stabilizing or mediating changes in global mean temperature4–7. However, these global proposals pose substantial governance challenges8–10, making regional interventions tailored toward targeted climate outcomes potentially more attractive in the near-term. In this study, we investigate the efficacy of regional marine cloud brightening in the North Pacific designed to mitigate extreme heat in the Western United States. We find cloud brightening in a remote mid-latitude region cools our target region more than brightening in a proximate subtropical region, but both schemes reduce the relative risk of dangerous summer heat exposure under present-day conditions, by 39% and 25% respectively. However, the same cloud brightening interventions under mid-century warming produce significantly hotter rather than cooler summers, both in the Western U.S. and other areas of the world. We trace this loss of efficacy to a nonlinear response of the Atlantic Meridional Overturning Circulation to the combination of greenhouse gas driven warming and regional cloud brightening. Our result demonstrates a risk in assuming that regional interventions that are effective under certain conditions will remain effective as the climate continues to change.
Randomized controlled trial of a positive emotion regulation intervention to reduce stress in family caregivers of individuals with Alzheimer’s disease: Protocol and design for the LEAF 2.0 study
Authors: Grote Veronika , Leong Caroline , Summers Amanda , Dowling Glenna , Snowberg Kari , Cotten Paul , Cheung Elaine , Yang DerShung , Addington Elizabeth L. , Moskowitz Judith T. 
Published: September 2023

Abstract
Background
Caring for a loved one with Alzheimer’s disease can be stressful, resulting in poorer emotional and physical health among family caregivers. Although supportive resources for caregivers are available, distance, caregiver health, and the daily demands of caregiving are barriers to access. Based on research demonstrating the importance of positive emotions in coping with stress, our previous trial showed that dementia caregivers who participated in facilitated, web-based delivery of a positive emotion regulation intervention called LEAF (Life Enhancing Activities for Family caregivers) experienced increased positive emotion and decreased depression and anxiety. Building on this evidence, the LEAF 2.0 study aims to test whether web-based, self-guided delivery can confer similar benefits for caregivers of individuals with Alzheimer’s disease.
Methods
This paper presents the design and methods for LEAF 2.0, a 3-arm web-based randomized controlled trial (N = 500) in which family caregivers of patients with Alzheimer’s disease (AD) are randomized to 1) the LEAF intervention facilitated remotely via the web (N = 200), 2) the LEAF intervention self-guided online (N = 200), or 3) an emotion reporting control (N = 100), which then crosses over to the intervention after approximately 6 months, half to the facilitated arm and half to the self-guided arm. We aim to 1) compare the effect of facilitated and self-guided LEAF positive emotion intervention to an emotion reporting control condition on AD caregiver well-being (positive emotion, depression, anxiety, and perceived stress) and secondary outcomes (caregiving burden, caregiving self-efficacy, positive aspects of caregiving, quality of care, and AD patient quality of life); 2) assess whether effects are mediated by improvements in positive emotion or other aspects of caregiver well-being; and 3) test whether caregiver age or gender or the care recipient’s dementia severity moderates the effects of the intervention.
Discussion
If demonstrated to be effective, LEAF 2 can be widely disseminated and ultimately have a significant impact on the stress experienced by AD caregivers and the well-being of people living with Alzheimer’s disease.
Trial Registration
ClinicalTrials.gov NCT03610698
Analysis of the clinical manifestations and diagnostic process of the pleural effusion associated with constrictive pericarditis
Authors: Wei Weifeng , Shen Panxiao , Liu Shaowei , Li Naijian , Zeng Yunxiang , Ma Lunchao , Wang Jinlin 
Published: September 2023

Abstract
Objectives: Constrictive pericarditis is one of the rare causes of pleural effusion and is easily misdiagnosed and missed clinically, precisely due to the non-specific clinical features of constrictive pericarditis.
Methods: In this study, we conducted a retrospective analysis of 19 cases of pathologically confirmed constrictive pericarditis. These patients were admitted to our hospital between January 2019 and December 2022 after pericardial stripping. The collected data included imaging findings, clinical manifestations, pleural effusion characteristics, postoperative pathology, and the diagnostic process.
Results: In this study, the age of the 19 patients ranged from 25 to 74 years, with a median age of 59 years. The duration of the disease varied from 20 days to 24 months, with a median duration of 4 months. All patients presented with bilateral pleural effusion, with or without pericardial lesions such as pericardial effusion or thickening. Pleural effusion biochemistry did not exhibit specific characteristics, and both etiology and pleural pathology were negative. Radiographic examinations, including cardiac ultrasound and chest CT, revealed signs of pericardial thickening and/or pericardial effusion or no abnormalities. Pericardial stripping was performed in all patients, and the postoperative pathology confirmed various degrees of thickened pericarditis, consistent with constrictive pericarditis. During a follow-up period of 6-18 months, most patients (17 out of 19) showed favorable recovery with no recurrence of bilateral pleural effusion.
Conclusions: In patients presenting with bilateral pleural effusion and pericardial lesions, the possibility of constrictive pericarditis should be considered. CT and cardiac ultrasound play a significant role in its diagnosis, while pericardial stripping serves as a confirmatory diagnostic method and an effective treatment approach.
A rolling bearing fault diagnosis technique based on fined-grained multi-scale symbolic entropy and whale optimization algorithm-MSVM
Authors: Wang Bing , Qiu Tao wen , Hu Xiong , Wang Wei 
Published: September 2023

Abstract
As a critical and fragile rotary supporting component in mechanical equipment, fault diagnosis of rolling bearing has been a hot issue. A rolling bearing fault diagnosis technique based on fined-grained multi-scale symbolic entropy and whale optimization algorithm-multiclass support vector machine (abbreviated as FGMSE-WOA-MSVM). Firstly, the vibration signals are decomposed with fine-grained multi-scale decomposition, and the symbolic entropy of the sub-signals at different analysis scales are extracted and constructed as the multi-dimension fault feature vector. In order to address the problem of sensitive parameters for MSVM model, whale optimization algorithm (abbreviated as WOA) is introduced to optimize the penalty factor and kernel function parameters to construct the optimal WOA-MSVM model. Finally, Instance analysis is carried out with bearing fault dataset from Jiangnan University to verify the parameters influence and the effectiveness on the unbalanced sample set. The results show that compared with different feature vector inputs and learning models such as KNN, DT, RF, etc., the proposed technique can achieve an accuracy rate of 99.33%, besides, the computation speed is fast and the diagnosis efficiency is high which means its potential value for engineering application.
Hexaxial external fixator versus intramedullary nail in treating segmental tibial fractures: a retrospective study
Authors: Zhao Zhiming , Shu Hengsheng , Jia Peng , Chen Xu , Guo Feng , Liu Yabin , Shi Bowen , Ji Guoqi , Cai Chengkuo , Sheng Yidong 
Published: September 2023

Abstract
Background
It’s difficult to treat segmental tibial fractures (STFs), which are intricate injuries associated with significant soft tissue damage. The aim of this study was to compare the clinical effect of hexaxial external fixator (HEF) and intramedullary nail (IMN) in treatment of STFs.
Methods
A total of 42 patients with STFs were finally recruited between January 2018 and June 2022. There were 25 males and 17 females with age range of 20 to 60 years. All fractures were classified as type 42C2 using the Arbeitsgemeinschaftfür Osteosythese/Orthopaedic Trauma Association (AO/OTA) classification. 22 patients were treated with HEF and 20 patients were treated with IMN. The condition of vascular and neural injuries, time of full weight bearing, bone union time and infection rate were documented and analyzed between the two groups. The mechanical medial proximal tibial angle (mMPTA), mechanical posterior proximal tibial angle (mPPTA), mechanical lateral distal tibial angle (mLDTA), mechanical anterior distal tibial angle (mADTA), hospital for special surgery (HSS) knee joint score, American Orthopaedic Foot and Ankle Society (AOFAS) ankle joint score, range of motion (ROM) of flexion of keen joint and ROM of plantar flexion and dorsal flexion of ankle joint were compared between the two groups at the last clinical visit.
Results
There were no vascular and neural injuries or other severe complications in both groups. All 22 patients in HEF group underwent closed reduction but 3 patients in IMN group were treated by open reduction. The time of full weight bearing was (11.3 ± 3.2) days in HEF group and (67.8 ± 5.8) days in IMN group(P < 0.05), with bone union time for (6.9 ± 0.8) months and (7.7 ± 1.4) months, respectively(P < 0.05). There was no deep infection in both groups. In the HEF group and IMN group, mMPTA was (86.9 ± 1.5)° and (89.7 ± 1.8)°(P < 0.05), mPPTA was (80.8 ± 1.9)° and (78.6 ± 2.0)°(P < 0.05), mLDTA was (88.5 ± 1.7)° and (90.3 ± 1.7)°(P < 0.05), while mADTA was (80.8 ± 1.5)° and (78.4 ± 1.3)°(P < 0.05). No significant differences were found between the two groups at the last clinical visit concerning HSS knee joint score and AOFAS ankle joint score, ROM of flexion of keen joint and ROM of plantar flexion of ankle joint (P > 0.05). The ROM of dorsal flexion of ankle joint in IMN group was (30.4 ± 3.5)°, better than (21.6 ± 2.8)° in HEF group (P < 0.05).
Conclusion
For STFs, HEF is superior to IMN in aspects of completely closed reduction, early full weight bearing, early bone union and alignment.
The Prognostic Significance of Postoperative High-Sensitivity Troponin I in Acute Type A Aortic Dissection
Authors: Matniyaz Yusanjan , Gao Ya-Xuan , Zhang Ke-Yin , Wang Wen-Zhe , Pan Tuo , Luo Yuan-Xi , Jiang Yi , Xue Yun-Xing , Wang Dong-Jin 
Published: September 2023

Abstract
Background
Acute type A aortic dissection (ATAAD) is a life-threatening condition requiring urgent surgical intervention. Despite advancements in surgical techniques, identifying reliable postoperative prognostic markers remains essential for optimizing patient outcomes. This study aimed to investigate the association between initial postoperative High-Sensitivity Troponin I (hs-cTnI) levels and short- to long-term prognosis in patients undergoing surgery for ATAAD.
Methods
A retrospective analysis was conducted on 384 patients diagnosed with ATAAD between March 2019 and March 2022. The hs-cTnI and other clinical features were collected and subjected to logistic and Cox regression analyses. The patients were stratified based on their initial postoperative hs-cTnI levels, with a cut off value of 1.54.
Results
The findings demonstrate that higher initial postoperative hs-cTnI ≥ 1.54 were independently associated with increased in-hospital mortality within 30 days post-surgery (OR: 1.505; 95% CI: 1.327, 1.704; p < 0.001). Mortality rates were consistently higher in the hs-cTnI ≥ 1.54 group at 30 days, 90 days, 1 year, and 4 years post-surgery (p < 0.001 for all). hs-cTnI ≥ 1.54 group showed higher incidences of gastrointestinal bleeding (p = 0.008), cerebral infarction (p = 0.039), endotracheal intubation (p < 0.001), and CRRT (p < 0.001). Gender disparities were observed in hs-cTnI levels, with male overrepresentation and reduced female representation in the hs-cTnI ≥ 1.54 group. High-Sensitivity Troponin I exhibited good specificity, sensitivity, and AUC for predicting short-term mortality. These findings emphasize the prognostic value of initial postoperative hs-cTnI levels and shed light on their utility for risk assessment and clinical decision-making.
Conclusion
This study underscores the clinical significance of early postoperative hs-cTnI monitoring in patients undergoing surgery for ATAAD. Elevated initial postoperative hs-cTnI levels are associated with increased short- and long-term mortality rates, as well as specific postoperative complications.
CNS Repopulation by Hematopoietic-Derived Microglia-Like Cells Corrects Progranulin deficiency
Authors: Gomez-Ospina Natalia , Colella Pasqualina , Sayana Ruhi , Suarez-Nieto Maria , Sarno Jolanda , Nyame Kwamina , Xiong jian , Vera Luisa Pimentel , Basurto Jessica Arozqueta , Corbo Marco , Limaye Anay , Davis Kara , Abu-Remaileh Monther 
Published: September 2023

Abstract

Hematopoietic stem cell transplantation can deliver therapeutic proteins to the CNS through donor-derived hematopoietic cells that become microglia-like cells. However, using standard conditioning approaches, hematopoietic stem cell transplantation is currently limited by low and slow engraftment of microglia-like cells. We report an efficient conditioning regimen based on Busulfan and a six-day course of microglia depletion using the colony-stimulating factor receptor 1 inhibitor PLX3397. Combining Busulfan-myeloablation and transient microglia depletion results in robust, rapid, and persistent microglia replacement by bone marrow-derived microglia-like cells throughout the CNS. Adding PLX3397 does not affect neurobehavior or has adverse effects on hematopoietic reconstitution. Through single-cell RNA sequencing and high-dimensional CyTOF mass cytometry, we show that microglia-like cells are a heterogeneous population and describe six distinct subpopulations. Though most bone-marrow-derived microglia-like cells can be classified as homeostatic microglia, their gene signature is a hybrid of homeostatic/embryonic microglia and border associated-macrophages. Busulfan-myeloablation and transient microglia depletion induce specific cytokines in the brain, ultimately combining myeloid proliferative and chemo-attractive signals that act locally to repopulate microglia from outside the niche. Importantly, this conditioning approach demonstrates therapeutic efficacy in a mouse model of GRN deficiency. Transplanting wild-type bone marrow into Grn-/- mice conditioned with Busulfan plus PLX3397 results in high engraftment of microglia-like cells in the brain and retina, restoring GRN levels and normalizing lipid metabolism.
Channel Coordination Attention for Crop and Weed Segmentation Neural Networks
Authors: Bai Xinfeng , Xue Yuming , Dai Hongli , Wang Luoxin , Bai Xin , Hu Xiaofeng , Li Bo 
Published: September 2023

Abstract
Convolutional neural network is widely used in the field of intelligent agricultural production, but in weed control, the complexity of the environment and the similarity between plants place higher demands on the task of crop and weed image recognition and segmentation. In this paper, a hybrid attention mechanism was proposed to establish global feature dependence by using channel autocorrelation matrix, named channel coordination attention. The attention mechanism established an autocorrelation matrix by obtaining the dependency relationships of feature channels, and used this matrix to aggregate spatial features in different directions to strengthen the location features. The resulting pair of spatial attention and previously obtained channel attention worked together on the input feature map to enhance feature representation capability. In this study, the reasonableness of the design of attention module was verified by burning experiments, and the proposed attention mechanism was superior to other mainstream attention, such as Squeeze-and-Excitation attention (SE), Convolutional Block Attention Module (CBAM), Coordinate Attention (CA), etc. in terms of interaction ratio, accuracy and average pixel accuracy on the Unet network model. In addition, the effectiveness of the proposed attention mechanism was demonstrated in different semantic segmentation models.