bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transplantation Through the Generations
Authors: Castagna Alberto , Mekelenkamp Hilda , Mcmonagle Lisa , Kenyon Michelle , Eeltink Corien , Liptrott Sarah Jayne 
Published: April 2023

AbstractWhilst the basic principles of HSCT remain the same, regardless of the age of the patient, there are a number of important additional considerations relating to transplantation of our younger and older patients and those of adolescent age. The principles outlined in this chapter serve as a valuable reminder supporting age-appropriate patient-centred care delivery. This chapter initially focuses on transplanting the child and its physiological and psycho-social aspects. Subsequently, the nursing challenges in the AYA population will be addressed. This chapter ends with considerations for treatment and care for the older adult.
Digitalisierung im Krankenhaus
Authors: Blase Nikola , Diehl Anke , Wasem Jürgen 
Published: April 2023

Zusammenfassung Die Digitalisierung in deutschen Krankenhäusern offeriert viel Potential für Verbesserungen. Doch wo stehen wir auf dem Weg zum Krankenhaus 4.0 und welche internationalen Digitalisierungsstrategien sind in den Blick zu nehmen? Wo sind Rationalisierungseffekte beim Personaleinsatz denkbar und wie lassen sich Digitalisierungsmaßnahmen bewerten? Der Beitrag beleuchtet Effekte auf das Krankenhauspersonal im Zuge der digitalen Transformation und wirft ein Schlaglicht auf die Möglichkeiten mit Blick auf die Verbesserung des Personaleinsatzes und eine Entlastung der Mitarbeitenden. Zudem zeigt er aktuell bestehende Hindernisse und Hürden sowie die resultierenden Herausforderungen mit Fokus auf das Krankenhauspersonal auf.
Das Pflegebudget der Krankenhäuser im dritten Jahr der Umsetzung: Analysen und Entwicklungen
Authors: Hentschker Corinna , Goerdt Gideon , Scheller-Kreinsen David 
Published: April 2023

ZusammenfassungSeit dem Jahr 2020 erfolgt die Krankenhausvergütung auf Basis von Fallpauschalen und einer Pflegepersonalkostenvergütung nach dem Selbstkostendeckungsprinzip. Der Beitrag analysiert die Daten der vereinbarten Pflegebudgets der Jahre 2020 und 2021 sowie die verfügbaren amtlichen Statistiken zur Pflegepersonalentwicklung in den Kliniken. Das vereinbarte Pflegebudget in der vorliegenden Strichprobe des Jahres 2021 steigt im Vergleich zum Vorjahr um 7 % und weist damit weiterhin Steigerungsraten auf, die deutlich oberhalb der allgemeinen Ausgabenentwicklung im Krankenhaus beziehungsweise oberhalb der Einnahmeentwicklung der GKV liegen. Der Personaleinsatz der Kliniken entwickelt sich unterschiedlich. Der Anteil des Personals mit mindestens dreijähriger pflegerischer Berufsausbildung liegt nahezu unverändert bei 88 %. Allerdings zeigen sich Verschiebungen zwischen den einzelnen Berufsgruppen. Beispielsweise stieg die Anzahl der Altenpfleger in den Kliniken deutlich. Gesetzgeberisch wurden im Jahr 2022 erneut viele Anpassungen vorgenommen. Zentrale Punkte sind eine Neuausgliederung und die Wiedereingliederung von Personal ohne formale pflegerische Qualifikation („Sonstige Berufe“) in die Fallpauschalen mit dem Ziel, Doppelfinanzierung zu vermeiden. Beide Maßnahmen sollen für die Jahre ab 2025 Anwendung finden. Des Weiteren wurden Fristen für die Budgetverhandlungen eingeführt.
Die Personalsituation im Krankenhaus im internationalen Vergleich
Authors: Köppen Julia , Busse Reinhard 
Published: April 2023

ZusammenfassungDeutschland verfügt im internationalen Vergleich über eine hohe Anzahl an Ärztinnen/Ärzten und Pflegefachpersonen, wie man Berichten und Ergebnissen aus Datenbanken der EU, der OECD und der WHO entnehmen kann. Werden die Zahlen auf Krankenhausebene betrachtet, bewegt sich Deutschland im Mittelfeld. Unter Hinzunahme von stationären Fallzahlen rangiert Deutschland im unteren Bereich. Befragungsdaten von Pflegefachpersonen aus zwölf Ländern vor über zehn Jahren haben bereits gezeigt, dass Pflegende in skandinavischen Ländern, den Niederlanden und der Schweiz deutlich weniger Patientinnen und Patienten versorgen müssen als Pflegende in Deutschland. Dieselbe Studie (RN4CAST) hat auch die Bewertung der Arbeitsumgebung erhoben und die Ergebnisse sind ebenfalls in den zuvor genannten Ländern besser. Doch nicht nur die Arbeitsumgebung unterscheidet sich international, sondern auch die Aufgabenteilung in Krankenhäusern, laut Ergebnissen der MUNROS-Studie.
Die Arbeitsmarktsituation in Krankenhäusern
Authors: Fuchs Michaela , Weyh Antje 
Published: April 2023

ZusammenfassungDer demographische Wandel beeinflusst den Arbeitsmarkt in Krankenhäusern in besonderem Maße. Einerseits steigt die Nachfrage nach Gesundheitsdienstleistungen und damit nach Personal, andererseits sinkt das Angebot an potenziellen Arbeitskräften. Dieser Beitrag enthält eine Analyse der Arbeitsmarktsituation in Krankenhäusern auf Basis administrativer Daten der Bundesagentur für Arbeit für den Zeitraum von 2013 bis 2021. Die personelle Struktur hängt eng mit der Berufsstruktur zusammen und ist geprägt von einem sehr hohen Anteil an Frauen und Teilzeitbeschäftigten. In den beschäftigungsstärksten Berufen offenbaren sich teils deutliche Arbeitskräfteengpässe, an denen auch das überdurchschnittlich hohe Lohnwachstum in den letzten Jahren nichts geändert hat. Individuelle Verlaufsanalysen zeigen, dass die Beschäftigten in den zentralen Berufen zwar häufig erwerbstätig bleiben, aber nicht zwangsläufig in ihrem ursprünglichen Beruf oder in Krankenhäusern. Die Ergebnisse unterstreichen die Notwendigkeit für die Krankenhäuser, sich als attraktive Arbeitgebende mit guten Arbeitsbedingungen zu positionieren, um Strategien für die Suche nach Arbeitskräften erfolgreich umsetzen zu können.
Existence of Running Solutions in a Relativistic Tricomi’s Equation Using Perturbation Theory
Authors: Daniel Cortés Z. , Alexander Gutierrez G. 
Published: April 2023

AbstractWe use perturbation methods to establish the existence of a second kind periodic solution (running solution) of a nonlinear Tricomi’s equation type under relativistic effects. First, we estimate conditions for the existence of either an equilibrium point or a second-kind periodic solution through the average method, where we assumed the nonlinear part as a positive perturbation. Then, we use the Melnikov function to estimate conditions for the existence of running solutions, considering the persistence of the homoclinic orbits associated with the conservative equation.
Laboratory Tests and Field Surveys to Explore the Optimum Frequency for GPR Surveys in Detecting Qanats
Authors: Hojat Azadeh , Ranjbar Hojjatollah , Karimi-Nasab Saeed , Zanzi Luigi 
Published: April 2023

AbstractIn this paper, we discuss the results of laboratory tests and field surveys using ground penetrating radar (GPR) method to detect qanats at the main campus of Shahid Bahonar University of Kerman (SBUK), Iran. The main purpose of laboratory experiments was to explore the optimum frequency of GPR surveys to detect qanats for the subsoil in the study site. We performed a variety of laboratory tests with a 3 GHz antenna to detect qanats (simulated using dielectric empty targets) hosted by sand with volumetric water content (VWC) values in the range 1.5–8%. The depth to each target was progressively increased until either approaching the edges of the sandbox or modelling a qanat depth for which GPR data could not detect the target anymore. The scaling factors were calculated for each test to estimate the maximum depth of detecting qanats as a function of the scaled GPR frequency. The results showed that in areas where the subsoil is dominated by sand, medium-frequency GPR antennas can penetrate to depths of a few tens of meters, but the penetration depth considerably decreases when the soil moisture and/or clay content of the medium increase. Based on the results of laboratory simulations, qanats are detectable at a maximum normalized depth of about 15–17 times of the wavelengths in very dry sands with VWC less than 5% while the detectable range rapidly drops down to less than 3 or 4 times of the wavelengths in more humid sands with VWC of about 8%. We also discuss the results of a few field GPR surveys that were measured using antennas with the 50 MHz and the 250 MHz frequencies in the northwestern part of the study area. The processed GPR images could detect a qanat in the position compatible with the results of previous remote sensing studies performed in the area. The depth to the detected qanat is 13.5 m, which is a little bit beyond the maximum limit predicted by the laboratory tests.
Pre-hospital tranexamic acid administration in patients with a severe hemorrhage: an evaluation after the implementation of tranexamic acid administration in the Dutch pre-hospital protocol
Authors: Gulickx Max , Lokerman Robin D. , Waalwijk Job F. , Dercksen Bert , van Wessem Karlijn J. P. , Tuinema Rinske M. , Leenen Luke P. H. , van Heijl Mark 
Published: April 2023

AbstractPurposeTo evaluate the pre-hospital administration of tranexamic acid in ambulance-treated trauma patients with a severe hemorrhage after the implementation of tranexamic acid administration in the Dutch pre-hospital protocol.MethodsAll patients with a severe hemorrhage who were treated and conveyed by EMS professionals between January 2015, and December 2017, to any trauma-receiving emergency department in the eight participating trauma regions in the Netherlands, were included. A severe hemorrhage was defined as extracranial injury with > 20% body volume blood loss, an extremity amputation above the wrist or ankle, or a grade ≥ 4 visceral organ injury. The main outcome was to determine the proportion of patients with a severe hemorrhage who received pre-hospital treatment with tranexamic acid. A Generalized Linear Model (GLM) was performed to investigate the relationship between pre-hospital tranexamic acid treatment and 24 h mortality.ResultsA total of 477 patients had a severe hemorrhage, of whom 124 patients (26.0%) received tranexamic acid before arriving at the hospital. More than half (58.4%) of the untreated patients were suspected of a severe hemorrhage by EMS professionals. Patients treated with tranexamic acid had a significantly lower risk on 24 h mortality than untreated patients (OR 0.43 [95% CI 0.19–0.97]).ConclusionApproximately a quarter of the patients with a severe hemorrhage received tranexamic acid before arriving at the hospital, while a severe hemorrhage was suspected in more than half of the non-treated patients. Severely hemorrhaging patients treated with tranexamic acid before arrival at the hospital had a lower risk to die within 24 h after injury.
Validation of the short forms of the Pelvic Floor Distress Inventory and the Pelvic Floor Impact Questionnaire in Estonian
Authors: Mikeltadze Iveta , Täär Katrin , Kadastik Ülle , Soplepmann Pille , Rull Kristiina 
Published: April 2023

Abstract
Introduction and hypothesis
Pelvic Floor Distress Inventory (PFDI-20) and the Pelvic Floor Impact Questionnaire (PFIQ-7) are reliable instruments for evaluating the quality of life in women with pelvic organ prolapse (POP). They have been translated and validated in many languages. The study was aimed at validating the Estonian translations of the PFDI-20 and PFIQ-7 tools.

Methods
The questionnaires were translated into Estonian using a multistep translation method. A total of 132 women were enrolled: patients with diagnosed POP (n=57) were allocated to test–retest reliability analyses, and those with no POP signs (n=88) completed the questionnaire only once. The total scores of questionnaires and their subscales of both patient and reference groups were compared. Item response rate, floor and ceiling effects, corrected item–total correlations, internal consistency, and convergent and discriminant validity were analyzed. The study was approved by the Ethics Committee of Human Research of the University Clinic of Tartu, Estonia, and informed consent was obtained from each participant.

Results
The translated questionnaires demonstrated good internal consistency (Cronbach's α values 0.77–0.93). The item response rate was 99%. Intra-class correlations (ICC) were strong for PFDI-20 and PFIQ-7 and their subscales ranged from 0.86 to 0.96. Construct validity of the tools demonstrated by manyfold higher scores among patients with POP compared with women without POP (p<0.0001).

Conclusions
The Estonian versions of the PFDI-20 and PFIQ-7 tools are reliable and valid instruments for assessing the quality of life in women with POP.
The History and Evolution of the West African College of Surgeons/Jos University Teaching Hospital Trauma Management Course
Authors: Sule Augustine Z. , Alayande Barnabas T. , Ojo Emmanuel O. , Taiwo Femi O. , Riviello Robert R. , Chirdan Lohfa B. , Ezeome Emmanuel R. , Mshelbwala Philip M. , Ugwu Benjamin T. , Yawe King‐David T. 
Published: April 2023

AbstractBackgroundInadequate trauma care training opportunities exist in Low‐ and Middle‐Income Countries. Jos University Teaching Hospital and the West African College of Surgeons (WACS) have synergized, over the past 15 years, to introduce a yearly, certified, multidisciplinary Trauma Management Course. We explore the history and evolution of this course.MethodsA desk review of course secretariat documents, registration records, schedules, pre‐ and post‐course test records, post‐course surveys, and account books complemented by organizer interviews was carried out to elaborate the evolution of the Trauma Management Course.ResultsThe course was started as a local Continuing Medical Education program in 2005 in response to recurring cycles of violence and numerous mass casualty situations. Collaborations with WACS followed, with inclusion of the course in the College's yearly calendar from 2010. Multidisciplinary faculty teach participants the concepts of trauma care through didactic lectures, group sessions, and hands‐on simulation within a one‐week period. From inception, there has been a 100% growth in lecture content (from 15 to 30 lectures) and in multidisciplinary attendance (from 23 to 133 attendees). Trainees showed statistically significant knowledge gain yearly, with a mean difference ranging from 10.1 to 16.1% over the past 5 years. Future collaborations seek to expand the course and position it as a catalyst for regional emergency medical services and trauma registries.ConclusionsMultidisciplinary trauma management training is important for expanding holistic trauma capacity within the West African sub‐region. The course serves as an example for Low‐ and Middle‐Income contexts. Similar contextualized programs should be considered to strengthen trauma workforce development.
Hierarchical registration method for surface quality inspection of long products
Authors: delaCalle F. J. , García D. F. , Usamentiaga R. , Nuño P. , Magadán L. 
Published: April 2023

AbstractManufacturing industry often uses 3D scanning technologies to inspect their products. Some of these techniques produce a point cloud that represent a section of the manufactured product. The clouds must be aligned to the model of the product in order to check its quality. Current registration methods are usually affected by dimensional problems or volumetric anomalies. This paper proposes a new method for the registration process aligning the cloud to the model in several steps. The first step is the state-of-the-art method. The second step uses the information acquired in the first one to perform a fine registration in order to not being affected by dimensional defects or little miss alignments in the previous step providing a huge improvement in the measurement of surface defects. In this paper, several techniques are proposed in order to provide a set of tools that the final users can tune to fit their needs. The whole procedure of registration can be run in real-time conditions using the sampling and caching strategies proposed. The methods proposed are tested over more than 10,000 profiles of a rail proving they successfully align the cloud and the model providing better results in the measurement of surface defects.
Progressive supranuclear palsy’s economical burden: the use and costs of healthcare resources in a large health provider in Israel
Authors: Barer Yael , Cohen Raanan , Grabarnik-John Meital , Ye Xiaolan , Zamudio Jorge , Gurevich Tanya , Chodick Gabriel 
Published: April 2023

Abstract
Background
Progressive supranuclear palsy (PSP) is a rare and fatal neurodegenerative movement disorder with no disease modifying therapy currently available. Data on the costs associated with PSP are scarce. This study aims to assess the direct medical expenditure of patients with PSP (PwPSP) throughout disease course.

Methods
This retrospective cohort study is based on the data of a large state-mandated health provider in Israel. We identified PwPSP who were initially diagnosed between 2000 and 2017. Each PwPSP was randomly matched to three health-plan members without PSP by birth-year, sex, and socioeconomic status. Healthcare resources’ utilization and related costs were assessed.

Results
We identified 88 eligible PwPSP and 264 people in the reference group; mean age at diagnosis was 72.6 years (SD = 8.4) and 53.4% were female. The annual direct costs of PwPSP have risen over time, reaching US$ 21,637 in the fifth year and US$ 36,693 in the tenth year of follow-up vs US$ 8910 in the year prior diagnosis. Compared to people without PSP, PwPSP had substantially higher medical expenditure during the years prior- and post-index date.

Conclusion
The present study demonstrates higher economic burden, which increases with time, in PwPSP as compared to those without.
PIK3CA mutation testing as a valuable molecular surrogate for lipomatosis of the median nerve: clinicopathological and molecular analysis of six cases
Authors: Osterloh Justus , Agaimy Abbas , Fried Frederick , Stoehr Robert , Janka Rolf , Arkudas Andreas , Horch Raymund E. 
Published: April 2023

AbstractLipomatosis of peripheral nerves (LPN, also known as fibrolipomatous or lipofibromatous hamartoma of peripheral nerves) is a very rare, benign, intraneural, tumorous lesion that predominantly involves the median nerve but may rarely affect any peripheral nerve. Recently, PIK3CA mutations have been reported in macrodactyly, a rare condition related to LPN, and in other localized lipomatous overgrowth syndromes. In this retrospective study, we report 6 cases of FPN involving the median nerve (4 of them identified among 570 patients with carpal tunnel syndrome who underwent surgical decompression at our center from 2012 to 2022 and two seen in consultation by one of the authors). All cases were diagnosed via biopsy or resection supplemented by MRI. Patients were 4 males and 2 females aged 23 to 60 years (mean 38 years). One patient with bilateral lesions had in addition extensive angiomatosis of the paravertebral region. Histological examination showed an abnormal amount of mature fatty tissue containing disordered fibrous bands, entrapping normal-looking nerve fibers with prominent perineurial and endoneurial fibrosis. Genetic analysis using snapshot assay constructed to detect hotspots mutations in PIK3CA revealed similar PIK3CA mutations (p.H1047R; c.3140A>G) in 5/6 cases (83.3%). Our study represents a further contribution to the literature on LPN and highlights the diagnostic value of PIK3CA mutation testing as surrogate tool in equivocal cases and in those lesions without associated macrodactyly, especially as the biopsy findings of this lesion are essentially nonspecific.
Claudin-10 is a new candidate prognostic marker in metastatic high-grade serous carcinoma
Authors: Davidson Ben , Doutel Delfim , Holth Arild , Nymoen Dag Andre 
Published: April 2023

AbstractThe objective of this study was to analyze the expression and prognostic role of the tight junction protein claudin-10 in high-grade serous carcinoma (HGSC). Claudin-10 protein expression by immunohistochemistry was analyzed in 588 HGSC (414 effusions, 174 surgical specimens). Expression in mesotheliomas (n = 97; 47 effusions, 50 surgical specimens) was studied for comparative purposes. CLDN10 mRNA expression by quantitative RT-PCR (qRT-PCR) was analyzed in 40 HGSC effusions. Claudin-10 protein expression was found in 360/588 (61%) HGSC vs. 19/97 (20%) mesotheliomas (p < 0.001), and was higher in HGSC surgical specimens compared to effusions (p < 0.001). qRT-PCR confirmed the presence of CLDN10 mRNA in HGSC effusions. High (> 25%) claudin-10 expression in HGSC effusions was significantly associated with shorter overall survival (OS; p = 0.036) and progression-free survival (PFS; p = 0.045) in univariate analysis, and was an independent prognosticator of OS in multivariate analysis (p = 0.045). In conclusion, claudin-10 protein expression is higher in HGSC compared to mesothelioma, although the diagnostic power of this marker appear to be lesser than other claudin family members. Claudin-10 expression in HGSC effusions is marker of more aggressive disease.
$$\ell $$-convex Legendre curves and geometric inequalities
Authors: Li Mingyan , Wang Guofang 
Published: April 2023

AbstractIn this paper we consider $$\ell $$
ℓ
-convex Legendre curves, which are natural generalizations of strictly convex curves. We generalize various optimal geometric inequalities, isoperimetric inequality, Bonnesen’s inequality and Green–Osher inequality, for strictly convex curves to ones for $$\ell $$
ℓ
-convex Legendre curves. Moreover we generalize the inverse curvature curve flow for this class of Legendre curves and prove that it always converges to a compact soliton after rescaling. Unlike in the class of regular curves, there are infinitely many compact solitons, which include circles and astroids.
„Expositions(E)-Probleme“ des nichttraumatologischen Schockraummanagements
Authors: Kumle Bernhard , Michael Mark , Kümpers Philipp , Hirschfeld-Warneken Andreas , Pin Martin , Hammer Niels , Bernhard Michael 
Published: April 2023

ZusammenfassungDas ABCDE-Schema (Atemwege, Beatmung, Kreislauf, neurologische Defizite, Exposition/Umwelt) ist integraler Bestandteil der Schockraumversorgung nichttraumatologischer Patienten. Während respiratorische und zirkulatorische Probleme sowie Vigilanzminderung und neurologische Notfallbilder den Großteil des Erkrankungsspektrums bei kritisch kranken Patienten ausmachen, sind sog. E‑Probleme mit 0,4–0,9 % eher selten. In diesem Übersichtsartikel soll das E‑Problem genauer besprochen und auf typische Vertreter der E‑Probleme, wie Hypo‑/Hyperthermie, Intoxikationen, Liegetrauma, starke Schmerzen und Agitationszustände, vertiefend eingegangen werden.
Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations
Authors: Serpelloni M. , Arricca M. , Ravelli C. , Grillo E. , Mitola S. , Salvadori A. 
Published: April 2023

AbstractCell motility—a cellular behavior of paramount relevance in embryonic development, immunological response, metastasis, or angiogenesis—demands a mechanical deformation of the cell membrane and influences the surface motion of molecules and their biochemical interactions. In this work, we develop a fully coupled multi-physics model able to capture and predict the protein flow on endothelial advecting plasma membranes. The model has been validated against co-designed in vitro experiments. The complete picture of the receptor dynamics has been understood, and limiting factors have been identified together with the laws that regulate receptor polarization. This computational approach might be insightful in the prediction of endothelial cell behavior in different tumoral environments, circumventing the time-consuming and expensive empirical characterization of each tumor.