bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variation in Biochemical Parameters in COVID-19 Patients Admitted at a Tertiary Care Dedicated COVID Hospital
Authors: Kumar Visesh , Mahto Mala , Kumar Sushil , Bansal Akash , Ranjan Alok , Ahmad Shamshad , Banerjee Ayan 
Published: April 2023

Introduction:
COVID-19 infection has a myriad of presentation. Rural India and other developing nations are relatively resource poor, not having access to modern specialized investigations. In this study, we tried to evaluate only biochemical parameters in predicting the severity of the infection. The aim of this study was to find a cost-effective means to predict the clinical course at the time of admission and thereby to reduce mortality and, if possible, morbidity by timely intervention.

Materials and Methods:
All COVID-19-positive cases admitted at our hospital from March 21 to December 31, 2020, were recruited in this study. The same acted as sham control at recovery.

Results:
We observed a significant difference in biochemical parameters at the time of admission and discharge, between mild/moderate disease and severe disease. We found slightly deranged liver function tests at admission, which becomes normal at the time of discharge. Urea, C-reactive protein (CRP), procalcitonin, lactate dehydrogenase, and ferritin concentrations in severe/critical patients were significantly higher than that in the mild/moderate group. Receiver operating characteristic curves were plotted to predict the severity on the basis of biochemical parameters independently, of the patients based on these values.

Conclusion:
We proposed cutoff values of certain biochemical parameters, which will help in judging the severity of the infection at admission. We developed a predictive model with a significant predictive capability for CRP and ferritin values, using normal available biochemical parameters, routinely done in resource-poor centers. Clinicians working in resource-poor situations will be benefitted by having an idea of the severity of the disease. Timely intervention will reduce mortality and severe morbidity.
Comparison of Oral Health-related Quality of Life and its Association with the Periodontal Status among the Adults
Authors: DSouza Henston , Rajguru Jagadish Prasad , Gupta Shivangi , Mouneshkumar CD , Choudhury Basanta Kumar , Karishma  
Published: April 2023

Background:
Oral health-related quality of life (OHRQoL) is used for evaluating needs of people, their health problems, their level of satisfaction, and various effects of any intervention which have been provided for recording of various nonclinical aspects of oral health.

Aim:
The objective of the study was to compare OHRQoL and its association with periodontal health among adult population.

Materials and Methods:
This prospective and cross-sectional study was conducted on 300 respondents who were diagnosed with periodontitis. 14-item containing Oral Health Impact Profile 14 (OHIP-14) questionnaire was used for study analysis. A single observer made clinical examinations. Mann–Whitney “U” and Kruskal–Wallis statistical tests were used for comparing the OHIP-14 scores. Statistically significance was set at P < 0.05.

Results:
Majority of study participants were of female gender (62.0%). A significant association was observed between loss of attachment and OHIP14 scores (P = 0.003).

Conclusion:
Poor periodontal health may affect the OHRQoL.
Clinico-Etiological Profile of the Elderly Population with Altered Mental Status in a Teaching Hospital
Authors: Dhar Minakshi , Debbarma Birata , Mukherjee Anirudh , Dasan Senkadhir 
Published: April 2023

Background:
This study aimed at evaluating the clinico-etiological profile of altered mental status (AMS) among elderly patients and making recommendations regarding management based on etiologies, thereby improving both morbidity and mortality outcomes.

Materials and Methods:
This retrospective observational study was conducted in a teaching cum tertiary care hospital. Two years data (from July 2017 to June 2019) were extracted from the medical records section, and 172 eligible participants were analyzed using descriptive statistics for clinical outcomes, demographic profiles, and various etiological factors.

Results:
A total of 1784 elderly inpatients (age >60 years) were screened from the records, and 172 eligible elderly AMS patients were found eligible for the study. The male elderly population consisted of 110 (63.95%), and the female elderly was 62 (36.04%). The mean age of the study population was 67.82 years. The etiological factors of AMS in the study population were neurological – 47.09% (n = 81), infection – 30.23% (n = 52), metabolic/endocrine – 16.27% (n = 28), pulmonary – 2.32% (n = 4), fall – 1.74% (n = 3), toxic cause – 1.16% (n = 2), and psychiatric illness – 1.16% (n = 2). The total mortality rate was 9.30% (n = 16).

Conclusion:
The main etiological factors of AMS in the elderly population were predominantly of neurological, septic, and metabolic causes. These factors were preventable and treatable by training physicians, staff (as most of the physicians in the developing countries are not trained in managing this fragile group of population with multiple comorbidities), and by decentralizing geriatrics health-care setups.
Formulation Optimization of Solid Dispersion of Candesartan Cilexetil
Authors: Kothawade Sachin Namdeo , Pande Vishal Vijay 
Published: April 2023

Context:
Antihypertensive effects were achieved by quickly hydrolyzing candesartan cilexetil (CC), an inactive prodrug of candesartan, into active candesartan during absorption in the gastrointestinal tract. Due to its weak water solubility, CC has an inadequate intestinal absorption and a low oral bioavailability.

Aim:
The goal of this study was to make the medication CC more soluble in water.

Materials and Methods:
Low viscosity hydroxypropyl methylcellulose (HPMC) E5LV was used to prepare the solid dispersions through spray drying.

Results:
Study of dissolution, Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), differential scanning calorimeter (DSC), and X-ray diffraction characterized the prepared solid dispersions. CC amorphized from its crystallized state, as shown by the findings from the SEM, DSC, and X-ray powder diffraction experiments. Comparing pure CC and solid dispersion, the dissolution rate was higher with the former. The surfactant and wetting property of HPMC E5LV slowed devitrification and had an anti-plasticization impact, increasing the solubility and stability of the solid dispersion.

Conclusion:
The final results indicated that the CC, a weakly water-soluble medication, dissolved much better in the solid dispersions.
Development of a New Validated Stability-Indicating High-Performance Thin-Layer Chromatography Method for Determination of Dosulepin HCl in Bulk and Marketed Formulation with Characterization of its Degradants by Liquid chromatography–Mass Spectrometry
Authors: Balap Aishwarya Ramchandra , Waghmare Ravina R. 
Published: April 2023

Aim:
Dosulepin hydrochloride is a tricyclic antidepressant. It acts by inhibition of the reuptake of biogenic amine and increasing available neurotransmitter levels at the synaptic cleft. The objective of this work is to develop a new validated stability-indicating high-performance thin-layer chromatography (HPTLC) method for the determination of dosulepin hydrochloric acid (HCl) in bulk and marketed formulation and characterization of the degradation products by liquid chromatography–mass spectrometry (LC–MS).

Materials and Methods:
The HPTLC method development of dosulepin HCl was performed on aluminum plates precoated with silica gel 60 F254 using dichloromethane: toulene: methanol: glacial acetic acid (GAA) (4:4:2:0.2 v/v) with densitometric detection at 220 nm. The method validation was done using linearity, precision, accuracy, and robustness parameter.

Results:
Linearity range for dosulepin HCl was found in between 150 and 900 ng/band correlation coefficient was 0.996. The % relative standard deviation for accuracy and precision was found <2%. The developed and validated HPTLC method is simple, accurate, precise, and specific.

Conclusion:
This study concludes that the dosulepin HCl undergoes degradation to different extent under different stress conditions. From the peak purity profile studies, it was confirmed that the peak of the degradation product was not interfering with the peak of drugs. Major acidic and oxidation degradation products were isolated and characterized by LC–MS and probable degradation pathway for dosulepin HCl was determined.
Rocking the Boat but Keeping it Steady
Authors: Krishnamoorthy Priyanka , Kosalram Kalpana 
Published: April 2023

Background:
Burnout is a stress-induced syndrome that predominantly affects adolescents. Some environmental and personal factors can contribute to the onset of burnout and its severe consequences, including attrition, sleep disorders, and depression.

Objective:
Our study examined the impact of the COVID lockdown on emotional intelligence, academic burnout, and academic performance.

Materials and Methods:
Data were collected from a sample of 471 school-going students. Participants are selected by simple random sampling by the randomization table technique. Participants completed questionnaires, including the evaluation of academic burnout (exhaustion, cynicism, and efficacy).

Results:
Among the study population, 59% were females, and 41% were males. The mean age was 15.5 ± 1.26 years. The mean score for Cynicism was 10.06 ± 3.8. The mean score for Academic Efficacy was 20.71 ± 4.63. The mean difference in Emotional Exhaustion Score between males and females was not statistically significant (P = 0.063). The mean difference in Cynicism Score between males and females was not statistically significant (P = 0.730). The mean difference between males and females was statistically significant in the Academic Efficacy and Total scores (P < 0.001).

Conclusion:
The findings suggest that emotional intelligence strongly correlates with burnout during the COVID-19 lockdown. Adaptive coping, mental health, and optimism help prevent academic burnout and consequently positively affect academic performance. Intervention and future research implications should be discussed.
Is perfusion index a surrogate indicator of left ventricular contractility in neonates? A prospective study
Authors: Seyad Sohail V. , Shambhu Sunil Kumar , Doreswamy Srinivasa Murthy 
Published: April 2023

Introduction:
Noninvasive blood pressure monitoring may not accurately reflect cardiac contractility in neonates due to low vascular tone. The perfusion index (PI) is a noninvasive method of assessing the strength of peripheral pulses. It is shown to have a significant correlation with the left ventricular output. This prospective study estimates the correlation between PI and cardiac contractility in neonates.

Methods and Results:
All hemodynamically stable neonates who were on substantial enteral feeds and not on any respiratory or inotropic support underwent measurement of PI and echocardiography examination. Various indices of left ventricular contractility were estimated, and the correlation coefficient between them and PI was determined. Fifty-six neonates were studied. The median (interquartile range [IQR]) PI was 1.5 (1.25-1.75). The median (IQR) PI in preterm neonates was 1.5 (1.2–1.8) and that in term neonates was 1.8 (1.25–2.7) (P = 0.064). PI had a correlation of 0.205 with fractional shortening (P = 0.129) and 0.13 with left ventricular ejection fraction (P = 0.821). The Spearman’s correlation coefficient between PI and velocity of circumference fiber shortening was 0.009 (P = 0.945). The Spearman’s correlation coefficient between PI and cardiac output was −0.115 (P = 0.400).

Conclusion:
The PI does not correlate with left ventricular contractility parameters in neonates.
The relationship between left ventricular dilation and right ventricular diastolic function in children with a patent ductus arteriosus
Authors: Miller Cole , Anderson William , Paolillo Joseph A. , Schwartz Matthew C. 
Published: April 2023

ABSTRACT
The impact of a dilated left ventricular (LV) on right ventricular (RV) diastolic function has not been investigated. We hypothesized that in patients with a patent ductus arteriosus (PDA), LV dilation causes elevation of the RV end-diastolic pressure (RVEDP) through ventricular-ventricular interaction. We identified patients’ ages 6 months to 18 years who underwent transcatheter PDA closure at our center from 2010 to 2019. One hundred and thirteen patients were included with a median age of 3 years (0.5–18). The median LV end-diastolic dimension (LVEDD) Z-score was 1.6 (−1.4–6.3). RVEDP was positively associated with RV systolic pressure (0.38, P < 0.01), ratio of pulmonary artery/aortic systolic pressure (0.4, P < 0.01), and pulmonary capillary wedge pressure (0.71, P < 0.01). RVEDP was not associated with LVEDD Z-score (0.03, P = 0.74). In children with a PDA, RVEDP was not associated with LV dilation, but was positively associated with RV systolic pressure.
PEMBAGIAN MEDIAN FILTER UNTUK EFISIENSI KOMPRESI VIDEO DEPTH
Authors: Panjaitan Christin Erniati , Tarigan Sri Wahyuni 
Published: April 2023

Penelitian ini menggunakan suatu algoritma yang menghasilkan kompleksitas yang rendah untuk kompresi video depth yang dimana video depthnya dihasilkan dari Microsoft Kinect. Kompresi yang rendah dibutuhkan untuk efisiensi coding dan meminimalkan proses komputasi. Di dalam framework yang dibangun, video depth disaring menggunakan Median Filter untuk menghilangkan sebagian noise yang disebabkan oleh normalisasi disparity dan melalui padding untuk menghilangkan kesalahan dalam proses pengukuran. Di dalam proses filter, kita melakukan implementasi blok yang saling tidak tumpah tindih untuk menurunkan kompleksitas komputasi. Setiap blok akan menggunakan ukuran jendela yang berbeda tergantung pada informasi tepi yang diperoleh. Di dalam penelitian ini, Media Filter dan hasil padding mengeluarkan bentuk video depth yang akan dikirim ke H.264/AVC. Dibandingkan dengan hasil kompresi tanpa filter, maka hasil penelitian ini menunjukkan pengurangan beban bit yang signifikan antara 23 – 32 % dan pengurangan kompleksitas antara 47 – 69 %.
PENGARUH KUALITAS SUMBER DAYA MANUSIA DAN DISIPLIN KERJA TERHADAP KINERJA PEGAWAI DI UNIVERSITAS DARMA AGUNG MEDAN
Authors: Siregar Maju , Panjaitan Doli Tua Mulia Raja 
Published: April 2023

Penelitian ini bertujuan untuk mengetahui ada tidaknya pengaruh yang signifikan kualitas SDM dan Disiplin kerja terhadap Kinerja Pegawai Di Universtas Darma Agung Medan. Metode penelitian menggunakan kualitatif dan kuantitatif, dimana instrumen angket diberikan kepada 31 orang sampel penelitian. Diperoleh hasil penelitian bahwa (1) Kualitas SDM terhadap Kinerja Pegawai terdapat nilai thitung 3,618 dan nilai probabilitas sig. 0,001 artinya Kualitas SDM memiliki pengaruh signifikan terhadap Kinerja Pegawai. (2) Disiplin Kerja terhadap Kinerja Pegawai terdapat thitung 4,243 dan nilai probabilitas sig. 0,000 artinya Disiplin Kerja memiliki pengaruh signifikan terhadap Kinerja Pegawai. (3) Pengaruh variabel kualitas kerja dan disiplin kerja terhadap kinerja pegawai yaitu sebesar 53,3%, dan sebesar 46,7% dipengaruhi faktor lain yang tidak dibahas dalam penelitian ini.
DESAIN TRANSFORMASI RIDE ON TOYS UNTUK ANAK BALITA
Authors: Mardiana Christin , Dharma Dwiki Satya 
Published: April 2023

Ride on toys merupakan salah satu sarana untuk mendukung pertumbuhan anak balita, Namun kebanyakan Ride on toys dipasaran hanya memiliki satu bentuk atau satu fungsi saja, berdasarkan observasi yang dilakukan pada keluarga, Ride on toys hanya memiiki jangka waktu 1 – 2 tahun saja dengan pola permainan yang sama.
Dalam hasil wawancara terhadap beberapa orang tua menyatakan diperlukan Ride on toys yang dapat bertahan dalam jangka waktu lama dan dapat multifungsi dalam penggunaannya. Tujuan dari penelitian ini yaitu mengembangkan Ride on toys untuk anak balita yang dapat bertransformasi bentuk dan mengembangkan mainan Ride on toys agar dapat digunakan dengan pola permainan yang lebih bervariasi.
Metode yang digunakan dalam penelitian ini yaitu metode kualitatif dan kuantitatif, yang dimana metode kuantitatif sebagai data pendukung dari metode kualitatif. Penelitian ini menggunakan analisis SWOT dan analisis desain. Analisis SWOT dan analisis desain dilakukan setelah data – data terkumpul yang kemudian dianalisis dan dapat menghasilkan sebuah sintesa desain. Hasil akhir dalam penelitian ini adalah pengembangan Ride on toys yang dapat bertransformasi bentuk menjadi skuter, sepeda keseimbangan, sepeda roda 3, dan kereta dorong.
Kata Kunci : Anak Balita, Desain, Mainan, Ride on Toys
Dampak Psikologis Dan Sosiologis Terhadap Pernikahan Berbeda Setatus Kewarganegaraan
Authors: Elisa Rohma Nafi 
Published: April 2023

The purpose of this research study is to find out the psychological and social impact on marriage of different citizenship status, in terms of the individualism it feels. The method used to see the psychological and sociological impact on marriage with different citizenship status is by using a literature study research method. This literature study (library research) was taken from several journals, books, and news related to issues of marriage between different countries, from a legal, religious, social, psychological perspective and the relationship between the two. The results of this study can be concluded that, the psychological impact that occurs from both partners, namely: (1) Difficulty in achieving goals in marriage, goals in marriages of different nationalities are like clothes that are used during life. Spirits, beliefs and habits that become rules continue to be added to each person who obeys both in his beliefs and society, including in household life. (2) Maintaining two large families from different countries, all risks must be accepted in marriages of different nationality status because everything is a choice made in finding a partner he chooses in marriage. (3) Fighting for influence in decision-making, both partners usually have a role and impact for their children to follow, especially habits in behavior and religion that they believe in. Then the sociological impacts can be concluded, (1) Communication that has not been fully maximized from the two partners, each individual with other individuals must communicate which is the main tool for fellow individuals to know each other and work together as well as make physical and non-physical contact directly or indirectly direct. (2) The socio-cultural differences held between the two partners, family life in different countries are described as examples of the activities of individual persons as part of which will continue to change at any time.
Keywords: Inter-Country Marriage, Psychological, Sociological
Peran Tokoh Masyarakat Dalam Pembagian Harta Waris terhadap Anak Angkat
Authors: Falah Nabilah 
Published: April 2023

Adopted children cannot inherit the assets of their adoptive parents and only have rights through a mandatory testament, the amount of which cannot be more than 1/3 of the assets left by their adoptive parents as stated in Article 209 paragraph (2) KHI. The fact that happened in the Bobosan sub-district there were 3 (three) cases of inheritance distribution for adopted children who received the entire adoptive parent's inheritance. This paper attempts to explain the role of community leaders in the distribution of the inheritance of adopted children that occurred in the Bobosan sub-district, Banyumas Regency. This type of research is field research using an empirical juridical approach. The data source used was obtained from primary data sources in the field by conducting in-depth interviews with the informants studied. The method used in the qualitative analysis, namely describing, interpreting and interpreting research data by linking role theory (role theory). Based on the results of the study it can be concluded that the role of community leaders in the distribution of the inheritance of adopted children in the Bobosan sub-district is a religious figure who is trusted by the community to be able to make decisions on inheritance distribution by considering the value of more benefit. According to the religious leader, the division of inheritance that occurs is a need for Ḍaruriyat, adopted children who live in dependence to live in their parents' house and continue the business of their adoptive parents. So that the family and the surrounding community consider the adopted child to be the full successor of the assets and efforts of the adoptive parents in order to prioritize the benefit of the adopted child.
Keywords: Roles, Religious Leaders, Inheritance, Adopted Children
The Role of Gold Nanoparticles/Au-PEG-PAMAM as Drug Delivery System for Treatment of Breast Cancer
Authors: A-Kadhim Murtadha M-Hussein , Kelkawi Ali Hamad Abd 
Published: April 2023

To enhance the cellular uptake and chemotherapeutic efficacy of a current chemotherapeutic medication, a nanoparticle drug carrier technology has been designed. Due to their distinctive electrical and optical characteristics, gold nanoparticles (Au NPs) have recently demonstrated intriguing medical and military uses. In the event that they come into touch with a biological system, little is known about their biocompatibility. Metallic nanoparticles have been successfully utilized for a kind of biological applications. A drug delivery system known as Au – PEG – PAMAM – DOX was produced by conjugating the dendrimer with the anti-cancer chemical doxorubicin (DOX) via an amide bond. The amount of DOX released from Au – PEG – PAMAM – DOX at a natural pH was negligible, but this amount significantly increased in an environment with a weak acidic milieu, according to studies on the release of medicines from acellular sources. A research into the intracellular release of the medication was carried out with the assistance of confocal laser scanning microscopy (CLSM). Recently conjugation to the nanosystem, in vitro viability experiments revealed an increase in the associated DOX cytotoxicity that could not be attributable to carrier components. This indicates that the effectiveness of the DOX was increased. In light of this, it has been hypothesized that the newly created pH-triggered multifunctional Au NPs- DOX nanoparticle system could pave the way for a viable platform for the intracellular delivery of a range of anticancer medicines. In the current study, the common Au NPs synthesis techniques and their well-established uses in diverse needs, particularly in biological sensing applications.