bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prevalence of osteoporosis in China, a community based cohort study of osteoporosis
Authors: Wang Jing , Shu Bing , Tang De-zhi , Li Chen-guang , Xie Xing-wen , Jiang Li-juan , Jiang Xiao-bing , Chen Bo-lai , Lin Xin-chao , Wei Xu , Leng Xiang-yang , Liao Zhang-yu , Li Bao-lin , Zhang Yan , Cui Xue-jun , Zhang Qing , Lu Sheng , Shi Qi , Wang Yong-jun 
Published: February 2023

BackgroundOsteoporosis has already been a growing health concern worldwide. The influence of living area, lifestyle, socioeconomic, and medical conditions on the occurrence of osteoporosis in the middle-aged and elderly people in China has not been fully addressed.MethodsThe study was a multicenter cross-sectional study on the middle-aged and elderly permanent residents, which gathered information of 22,081 residents from June 2015 to August 2021 in seven representative regions of China. The bone mineral density of lumbar vertebrae and hip were determined using the dual-energy X-ray absorptiometry densitometer instruments. Serum levels of bone metabolism markers were also measured. Information about education, smoking, and chronic diseases were also collected through face-to-face interviews. Age-standardized prevalence and 95% confidence intervals (CIs) of osteopenia and osteoporosis by various criteria were estimated by subgroups and overall based on the data of China 2010 census. The relationships between the osteoporosis or osteopenia and sociodemographic variables or other factors were examined using univariate linear models and multivariable multinomial logit analyses.ResultsAfter screening, 19,848 participants (90%) were enrolled for the final analysis. The age-standardized prevalence of osteoporosis was estimated to be 33.49%(95%CI, 32.80–34.18%) in the middle-aged and elderly Chinese permanent residents, for men and women was 20.73% (95% CI, 19.58–21.87%) and 38.05% (95% CI, 37.22–38.89%), respectively. The serum concentrations of bone metabolic markers, and calcium and phosphorus metabolism were influenced by age, body mass index (BMI), gender, education level, regions, and bone mass status. Women, aged 60 or above, BMI lower than 18.5 kg/m2, low education level including middle school, primary school and no formal education as well as current regular smoking, a history of fracture were all significantly associated with a higher risk of osteoporosis and osteopenia in the middle-aged and elderly people.ConclusionsThis study revealed dramatic regional differences in osteoporosis prevalence in China, and female, aged 60 or older, low BMI, low education level, current regular smoking, and a history of fracture were associated with a high risk of osteoporosis. More prevention and treatment resources should be invested into particular population exposed to these risk factors.
Implementation of UNICEF and WHO's care for child development package: Lessons from a global review and key informant interviews
Authors: Ahun Marilyn N. , Aboud Frances , Wamboldt Claire , Yousafzai Aisha K. 
Published: February 2023

IntroductionIn the last decade, there has been increased global policy and program momentum to promote early childhood development. The Care for Child Development (CCD) package, developed by UNICEF and the WHO, is a key tool responding to the global demand. The CCD package comprises two age-specific evidence-based recommendations for caregivers to 1) play and communicate and 2) responsively interact with their children (0–5 years) and was designed to be integrated within existing services to strengthen nurturing care for child development. The aim of this report was to provide an up-to-date global review of the implementation and evaluation of the CCD package.MethodsIn addition to a systematic review of 55 reports, we interviewed 23 key informants (including UNICEF and WHO personnel) to better understand the implementation of CCD.ResultsThe CCD package has been or is being implemented in 54 low- and middle-income countries and territories, and it has been integrated into government services across the health, social, and education sectors in 26 countries. Across these contexts, CCD has been adapted in three primary ways: 1) translations of CCD materials (mostly counseling cards) into local language(s), 2) adaptations of CCD materials for the local context, vulnerable children, or a humanitarian/emergency setting (e.g., including local play activities, using activities that are better suited to children with visual impairments), and 3) substantive modifications to the content of CCD materials (e.g., expansion of play and communication activities, addition of new themes, creation of a structured curriculum). While there is promising evidence and examples of good implementation practice, there has been mixed experience about implementation of CCD with respect to adaptation, training, supervision, integration into existing services, and monitoring implementation fidelity and quality. For example, many users of CCD found difficulties with training the workforce, garnering buy-in from governments, and ensuring benefits for families, among others.DiscussionAdditional knowledge on how to improve the effectiveness, implementation fidelity and quality, and acceptance of CCD is needed. Based on the findings of the review we make recommendations for future efforts to implement CCD at-scale.
Distinct differences in immunological properties of equine orthobiologics revealed by functional and transcriptomic analysis using an activated macrophage readout system
Authors: Pezzanite Lynn M. , Chow Lyndah , Griffenhagen Gregg M. , Bass Luke , Goodrich Laurie R. , Impastato Renata , Dow Steven 
Published: February 2023

IntroductionMultiple biological therapies for orthopedic injuries are marketed to veterinarians, despite a lack of rigorous comparative biological activity data to guide informed decisions in selecting a most effective compound. Therefore, the goal of this study was to use relevant bioassay systems to directly compare the anti-inflammatory and immunomodulatory activity of three commonly used orthobiological therapies (OTs): mesenchymal stromal cells (MSC), autologous conditioned serum (ACS), and platelet rich plasma (PRP).MethodsEquine monocyte-derived macrophages were used as the readout system to compare therapies, including cytokine production and transcriptomic responses. Macrophages were stimulated with IL-1ß and treated 24 h with OTs, washed and cultured an additional 24 h to generate supernatants. Secreted cytokines were measured by multiplex immunoassay and ELISA. To assess global transcriptomic responses to treatments, RNA was extracted from macrophages and subjected to full RNA sequencing, using an Illumina-based platform. Data analysis included comparison of differentially expressed genes and pathway analysis in treated vs. untreated macrophages.ResultsAll treatments reduced production of IL-1ß by macrophages. Secretion of IL-10 was highest in MSC-CM treated macrophages, while PRP lysate and ACS resulted in greater downregulation of IL-6 and IP-10. Transcriptomic analysis revealed that ACS triggered multiple inflammatory response pathways in macrophages based on GSEA, while MSC generated significant downregulation of inflammatory pathways, and PRP lysate induced a mixed immune response profile. Key downregulated genes in MSC-treated cultures included type 1 and type 2 interferon response, TNF-α and IL-6. PRP lysate cultures demonstrated downregulation of inflammation-related genes IL-1RA, SLAMF9, ENSECAG00000022247 but concurrent upregulation of TNF-α, IL-2 signaling, and Myc targets. ACS induced upregulation of inflammatory IL-2 signaling, TNFα and KRAS signaling and hypoxia, but downregulation of MTOR signaling and type 1 interferon signaling.DiscussionThese findings, representing the first comprehensive look at immune response pathways for popular equine OTs, reveal distinct differences between therapies. These studies address a critical gap in our understanding of the relative immunomodulatory properties of regenerative therapies commonly used in equine practice to treat musculoskeletal disease and will serve as a platform from which further in vivo comparisons may build.
Parthenogenetic Reproduction in Strumigenys Ants: An Update
Authors: Wang Chu , Sung Ping-Jui , Lin Chung-Chi , Ito Fuminori , Billen Johan 
Published: February 2023

Parthenogenetic reproduction is a common feature for social Hymenoptera, as males typically develop from unfertilized eggs (arrhenotoky). Production of female offspring without the involvement of sperm (thelytoky) also exists but is rather exceptional as it has been reported for only 16 ant species so far. Three of these belong to the genus Strumigenys: S. hexamera, S. membranifera and S. rogeri. Our observations on the reproductive biology in various Oriental Strumigenys species extends this list of thelytokous ants with three more species: S. emmae, S. liukueiensis and S. solifontis. Of these six thelotykous species, S. emmae, S. membranifera and S. rogeri are known as tramp species. Reproduction without the need to fertilize eggs no doubt offers these species a considerable advantage when establishing colonies in new environments. Published histological data on S. hexamera and S. membranifera already showed that the queens possess a functional spermatheca. We now provide evidence that this is also the case for the four other thelytokous Strumigenys species. Retaining a functional spermatheca and reproductive system may keep the queens ready for the exceptional event of mating and hence increase genetic variability, as males do occur very rarely.
Role of Resuscitation Promoting Factor-like Protein from Nocardiopsis halophila
Authors: Zhang Yufan , Liu Jingjing , Cao Min , Zhang Yujia , Zhang Xiumin 
Published: February 2023

Resuscitation promoting factors (Rpf), a class of proteins secreted by gram-positive bacteria including actinobacteria, promote the resuscitation of dormant bacteria and spore germination. Here, we describe the reconstitution of the resuscitation promoting activity of the Rpf protein from Nocardiopsis halophila CGMCC 4.1195T in vitro and in vivo. The Rpf protein was expressed in the host Escherichia coli BL21 codon plus (DE3) and was confirmed to have a significant resuscitation effect on the viable but non-culturable (VBNC) N. halophila. Subsequently, the rpf gene of N. halophila was knocked out. We found that the growth rate of the mutant strain (Δrpf) was slower than that of the wild strain, and the former produced significantly shorter spores than the wild-type strain. Our results confirmed the activity of the Rpf protein in N. halophila to promote dormant bacteria resuscitation. This study will lay the foundation for the application of the Rpf protein from N. halophila to exploit actinomycetes resources.
Kecerdasan Emosional Terhadap Organizational Citizenship Behavior (OCB) pada Karyawan PT. Indomarco Adi Prima Padang
Authors: Andhika Anggawira  , Aditya Hedrian  
Published: February 2023

Kecerdasan emosi perlu dimiliki oleh setiap orang, terutama bagi seorang karyawan. Penelitian ini dilakukann untuk mengetahui hubungan antara kecerdasan emosional terhadap organizational citizen Behavirship pada karyawan PT. Indomarco Adi Prima Cabang Padang. PT. Indomarco Adi Prima Cabang Padang merupakan salah satu unit bisnis dari PT. Indofood Sukses Makmur Tbk yang bergerak dalam bidang distribusi customer product. Lazimnya perusahaan tentu saja memiliki Standar Operasional dan pemberian reward yang bertujuan meningkatkan kinerja karyawan. Pemberian reward dalam perilaku sukarela yang dilakukan karyawan disebut dengan organizational citizen behaviorship. Dalam penelitian ini peneliti menggunakan Teknik non-probability sampling dengan jenis sampling jenuh sebanyak 62 karyawan PT. Indomarco Adi Prima Cabang Padang. Dalam penelitian ini peneliti menggunakan dua buah skala yaitu skala Kecerdasan Emosional dan skala organizational citizen behabiorship. Skala kecerdasan emosional disusun berdasarkan empat dimensi yaitu Mengenali emosi diri, Mengelola emosi, Motivasi, Empati, Membina hubungan sosial, sedangkan skala Organizational Citizenship Behavior disusun dengan menggunakan dimensi yang terdiri dari: altruism, conscientiousness, sportmanship, courtesy, civic virtue. Data dari skala yang digunakan dari 62 karyawan kemudian di hitung korelasinya dengan menggunakan metode korelasi product moment pearson melalui program SPSS. Dari pengolahan data dengan menggunakan program tersebut didapat hasil r=0,856, p sig. 0.000 < 0,05. Hasil ini menunjukkan bahwa kecerdasan emosional memiliki hubungan yang sifatnya positif dan signifikan terhadap perilaku organizational citizen behaviorship, dengan kata lain semakin tinggi kecerdasan emosional seseorang maka semakin besar munculnya perilaku Organizational citizen behaviorship, begitu juga sebaliknya. Dan kecerdasan emosional memberikan sumbangan sebesar 73 % terhadap organizational citizen behaviorship.
Effects of photoacid generator decomposition on dissolution kinetics of poly(4-hydroxystyrene) in tetraalkylammonium hydroxide aqueous solutions
Authors: Iwashige Yutaro , Ito Yuko Tsutsui , Kozawa Takahiro , Sakamoto Kazuo , Muramatsu Makoto 
Published: February 2023

Abstract
For the advancement of lithography, the resist materials and processes are the most critical factors. In particular, the process of developing resist materials is important in reducing the line width roughness and stochastic defects. In this study, a quartz crystal microbalance method was used to investigate the dissolution dynamics of poly(4-hydroxystyrene) (PHS) films containing triphenylsulfonium nonaflate (TPS-nf) in tetraalkylammonium hydroxide (TAAH) aqueous solutions. The time required for dissolution increased with the alkyl chain length of TAAH. The dissolution rate of PHS films increased with UV irradiation dose for tetramethylammonium hydroxide and tetraethylammonium hydroxide developers, whereas the dissolution time increased for the tetrabutylammonium hydroxide developer. For the tetrapropylammonium hydroxide developer, the dissolution time of PHS films without postexposure baking (PEB) slightly decreased with UV irradiation, whereas that with PEB increased. Both the surface free energy of PHS films and the molecular size of TAAH are considered to affect dissolution kinetics.
Pengaruh Penggunaan Gadget Terhadap Pola Belajar Siswa di SMPN 4 Pamekasan
Authors: Sri Rizqi Wahyuningrum  , Fitriyah  
Published: February 2023

Penelitian ini dilatarbelakangi oleh pengaruh penggunaan gadget sangatlah berdampak buruk bagi anak usia sekolah, terutama pada pola belajarnya. Dengan adanya gadget terutama seorang pelajar pola belajarnya menjadi menurun, yang awalnya fokus pada belajar malah dihabiskan waktunya untuk bermain gadget. Ada tidaknya pengaruh penggunan gadget terhadap pola belajar siswa di SMPN 4 Pamekasan dan seberapa besar pengaruh penggunaan gadget terhadap pola belajar siswa di SMPN 4 Pamekasan menjadi poin penting untuk dibahas. Pertimbangan-pertimbangan dalam pola belajar yaitu: Tujuan pengajaran, karakteristik bahan yang akan diajarkan, alokasi waktu yang tersedia, karakteristik siswa, dan kemampuan guru itu sendiri. Penelitian ini menggunakan metode kuantitatif. Teknik pengumpulan data yang digunakan yaitu kuesioner. Populasi dalam penelitian ini yaitu 102 siswa. Teknik pengambilan sampel menggunakan teknik sampel proposional. Dan teknik analisis data yang digunakan yaitu menggunakan statistik deskriptif dengan analisis data menggunakan uji korelasi product moment, uji-t dan regresi linier sederhana. Dari hasil penelitian ini menunjukkan bahwa penggunaan gadget (X) berpengaruh secara signifkan terhadap pola belajar siswa (Y). Hal ini terlihat dari nilai 4,121 lebih besar dari 2,024, dengan nilai signifikan 0,000 kurang dari 0,005. Dan besar pengaruh penggunaan gadget terhadap pola belajar siswa berdasarkan korelasi product moment dihasilkan sebesar 0,556 dengan nilai signifikan 0,000 kurang dari 0,05. Dan berdasarkan regresi linier sederhana dihasilkan sebesar 0,511.
Biosintesis dan karakterisasi nanopartikel tembaga oksida (CuO) menggunakan ekstrak rimpang kencur (Kaempferia galanga L.)
Authors: Rahmawati Efrilia R , Nazriati Nazriati 
Published: February 2023

Penggunaan nanopartikel telah berkembang pesat dalam berbagai bidang menyebabkan kebutuhan nanopartikel meningkat. Nanopartikel menjadi material yang banyak diminati karena memiliki banyak keunggulan jika dibandingkan dengan material jenis lain seperti raw material dan material yang berukuran lebih besar dari nanopartikel. Salah satu nanopartikel yang dikembangkan adalah nanopartikel CuO. Nanopartikel CuO umumnya disintesis dengan metode kimia dan fisika. Metode kimia dan fisika memberikan dampak negatif bagi lingkungan. Alternatif metode yang dapat digunakan adalah biosintesis. Penelitian ini bertujuan untuk melakukan biosintesis nanopartikel CuO menggunakan ekstrak rimpang kencur (Kaempferia galanga L.). Ekstrak rimpang kencur (Kaempferia galanga L.) berperan sebagai agen capping dan penstabil dalam pembentukan nanopartikel CuO. Biosintesis nanopartikel CuO berhasil dilakukan dengan ditunjukkannya puncak-puncak pada difraktogram XRD pada sudut 2θ: 32,5°; 35,5°; 38,77°; 46,3°; 48,77°; 53,48°; 58,28°; 61,55°; 66,28°; 66,28°; 68,04°; 72,44°; 75,08°; dan 82,77° dan diperoleh pita serapan FTIR pada bilangan gelombang 594 dan 469 cm-1. Hasil Penelitian menunjukkan nanopartikel CuO memiliki ukuran partikel pada pH 10, 11, dan 12 secara berturut-turut sebesar 24,04; 23,84; dan 22,68 nm dengan morfologi berbentuk lempengan serta nilai energi celah pita nanopartikel CuO yang diperoleh sebesar 5,25 eV.
Editorial
Authors: Nagel Siegfried , Klenk Christoffer , Stegmann Pascal 
Published: February 2023

The vision of the University of Bern is "knowledge generates value". In the context of this guiding idea, Bernese Sport Science works as “problem-oriented Sport Science”, taking sound methodical, theoretical, and interdisciplinary approaches to achieving impact across scientific and societal dimensions.
The programme of the 2023 SGS conference sheds light on the following perspectives:

Sport science generates value: Sport science makes an important contribution to the generation and transfer of knowledge in organisations and institutions in physical education, health promotion, high-performance sport and mass sport.

Knowledge of sport generates value: The knowledge generated in research contributes to the further development of physical education, to the targeted promotion of health and physical activity, to ethically optimized performance in elite sport and to ways people actively spend their leisure time.

Sport generates value: The social value of sport has multi-layered effects, such as personal development, teaching norms and values, the promotion of physical performance and health, and contributing to integration and social cohesion.

A look at the Book of Abstracts shows a rich and inspiring scientific programme with nearly 100 contributions of academics and practitioners generating knowledge along the three perspectives described. During the conference, there were three keynotes from outstanding experts in the field of sport science, the Young Investigator Award with five presentations of talented young researchers, twelve thematic symposia, eight oral sessions with forty presentations and two poster sessions with short presentations.
Besides the scientific contributions, the conference served as network platform that enabled many opportunities for fruitful and vibrant discussions as well as to connect with colleagues and establish research networks. None of this would have been possible without our fantastic organising team, the significant support of the SGS, particularly its board and the scientific committee and the commitment of researchers and practitioners in Switzerland and beyond that contributed to the conference’s success. Thank you very much to all!
We hope you enjoy reading the contributions of the Book of Abstracts.
For the local programme committee
Siegfried Nagel, Christoffer Klenk & Pascal Stegmann
Physical but not cognitive demand of an exercise bout influences subsequent affective inhibition
Authors: Mücke Manuel , Greco Antonella , Müller Tabea , Gerber Markus , Pühse Uwe , Ludyga Sebastian 
Published: February 2023

Background
The school curriculum places high demands on students’ cognitive performance, including the executive domain of inhibitory control. Physical activity breaks have been suggested to restore students’ cognitive resources. However, it is unclear which properties (i.e. physical effort and cognitive load) of the physical activity break are suited best to improve subsequent cognitive performance. Therefore, the aim of our study was to investigate the effect of exercise with different physical effort and cognitive load on subsequent inhibitory control.
Methods
Thirty-five healthy right handed children aged 9 to 13 years were recruited from an academic high school in Basel, Switzerland. On four different days at least one week apart and in randomized order, participants underwent short exercise sessions on an interactive exergaming wall (SMARTfit Single, SMARTfit, USA). The sessions lasted 10 min and combined high (or low) physical effort with high (or low) cognitive load. Participants rated their perceived exhaustion and cognitive load using an RPE scale and the NASA task load index. Before and after the exercise sessions, a standard Stroop task and an affective Stroop task were performed to account for changes in inhibitory control with and without an additional component of emotion processing.
Results
The manipulation check showed that the high physical effort condition was related to higher rated perceived exhaustion and the high cognitive load condition to higher scores on the NASA task load index. Statistical analysis using 2 x 2 ANOVA revealed that independent from cognitive load, physical effort influenced reaction time on the affective, but not the standard Stroop task. This indicated a greater improvement following exercise at low compared to high physical effort in both the congruent and incongruent trials. This effect was not due to a speed-accuracy trade-off, given that no main effect of physical effort was found for accuracy. There were no main effects of cognitive load and no interaction of physical effort and cognitive load.
Conclusion
Our results indicated that in school children, lower exercise intensity is more suitable for improving subsequent inhibitory control than exercise with higher physical effort. However, this effect only seems to be present in situations where cognitive challenge is combined with emotionally charged stimuli. This has implications for recommendations on how to optimally organize students’ physical activity during school breaks.