bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction models for post‐traumatic stress disorder in family members of ICU patients: A systematic review
Authors: Zhang Xinyu , Sun Xiao , Cao Qianqian , Li Qihong , Li Rongqing , Zhang Zikai , Jiang Jinxia , Zeng Li 
Published: January 2025

AbstractBackgroundSeveral predictive models have been developed for post‐traumatic stress disorder (PTSD) in intensive care unit (ICU) family members. However, significant differences persist across related studies in terms of literature quality, model performance, predictor variables and scope of applicability.AimThis study aimed to systematically review risk prediction models for PTSD in family members of ICU patients, to make recommendations for health care professionals in selecting appropriate predictive models.Study DesignChina National Knowledge Infrastructure, VIP database, Wanfang database, SinoMed, PubMed, Web of Science, Cumulative Index to Nursing and Allied Health Literature, The Cochrane Library, Embase and OVID were searched from inception to 1 May 2024. Two independent researchers conducted literature screening, data extraction and applied a risk of bias assessment tool for predictive models to evaluate included studies. The systematic review was registered on PROSPERO (registration number: CRD42024560815).ResultsSeventeen studies were included, with sample sizes ranging from 32 to 2734. Incidence rates of outcomes ranged from 1.6% to 63.6%. The most frequently used predictors were relative's female sex, longer duration of ICU stay, patient's death in the ICU and type of relationship with the patient. Two models reported area under the receiver operating characteristic curve (AUC) values ranging from 0.73 to 0.74; only three models reported calibration, and one study conducted internal validation. Overall, the 17 studies showed good applicability but exhibited a high risk of bias, particularly in data analysis.ConclusionsResearch on predictive models for PTSD risk in family members of ICU patients is in the developmental stage. Future studies should validate existing models or develop high‐performance localized predictive models.Relevance to Clinical PracticePTSD can have a significant impact on the families of ICU patients, making early identification of high‐risk populations essential for health care professionals to implement timely interventions.
Assessment of Insertion Torque, Primary and Secondary Stability in Immediate, Early and Delayed Implant Placement in the Maxilla of Elderly Patients: A Prospective Cohort Study
Authors: Win Kaung Zaw , Pimkhaokham Atiphan , Kaboosaya Boosana 
Published: January 2025

ABSTRACTObjectiveThis prospective cohort study assessed the effect of implant placement protocols on the insertion torque (IT), primary and secondary stability placed in maxilla in elderly.Material and MethodsA total of 26 implants were placed in the maxillary regions, categorised into three groups: immediate placement after tooth extraction (immediate group), placement 2 weeks–6 months after extraction (early group) and placement more than 6 months after extraction (delayed group). The IT and primary stability were recorded at the time of implant placement, while secondary stability was assessed during a follow‐up visit 60–120 days post‐surgery. Additionally, other factors influencing outcomes, such as gender, location of implant placement, macrostructural design, length and diameter of implants, were recorded.ResultsThe IT demonstrated a correlation with primary implant stability (rs = 0.504, p = 0.009). However, no significant correlation was observed with secondary stability. There were no significant differences in IT (p = 0.45) and primary stability (p = 0.51) among the three groups. However, the early implant placement group exhibited significantly higher secondary stability compared to the delayed group (p = 0.03). Significant differences were observed among implant placement protocols in terms of secondary stability in females (p = 0.03) and tapered implant (p = 0.008).ConclusionsThe IT and primary stability did not serve as reliable predictors of secondary stability in implant placement in the maxilla of elderly patients. However, the early implant placement protocol showed superiority over both immediate and delayed placement protocols in terms of achieving secondary stability. Specifically, gender and macrostructural design emerged as influential factors affecting secondary stability.
Second‐generation antipsychotic‐induced dystonia: Analysis using the Japanese Adverse Drug Event Report (JADER) database
Authors: Ebina Takumi , Iwamoto Kunihiro , Ando Masahiko , Ikeda Masashi 
Published: January 2025

AimThis study aimed to explore the comparative risks for dystonia among different second‐generation antipsychotics (SGAs), the influence of sex, and the relationship between the time‐to‐onset of dystonia and its outcomes.MethodsWe analyzed data from the Japanese Adverse Drug Event Report database from April 2004 to November 2023. Cases involving oral SGAs, excluding clozapine, were extracted. We used the odds ratios to assess the reporting proportions among SGAs and sex, analyzed the median time‐to‐onset and interquartile ranges (IQRs), and conducted a receiver operating characteristic (ROC) curve analysis to investigate the time‐to‐onset of dystonia and its relationship to outcomes.ResultsWe extracted 9837 cases involving oral SGAs. Lurasidone was associated with a significantly higher proportion of dystonia reports than risperidone, aripiprazole, quetiapine, and olanzapine. The reporting proportion of dystonia associated with aripiprazole was lower than that of paliperidone and risperidone, but higher than that of quetiapine and olanzapine. Female sex was significantly associated with a higher reporting proportion of dystonia compared with males. Among the 148 cases of oral SGA‐induced dystonia, the median time‐to‐onset was 125 days (IQR, 19.75–453.25 days). Divided into the three outcome groups (recovered, improved, and unrecovered/residual), those with better outcomes had a shorter time‐to‐onset than those with poorer outcomes. ROC curve analysis suggested a threshold of 91.5 days for discriminating outcomes, with a sensitivity of 71.7% and specificity of 69.9%.ConclusionsThe risks of dystonia may vary among SGAs and between sexes. SGA‐induced dystonia often manifests in the tardive form.
Aesthetic rehabilitation in lower mandibular area for agenesis in site 4.2: A case report and literature review
Authors: Palmacci Matteo , Saverino Marco , Pancrazi Gian Luca , Ferraro Costanza , Ceresoli Lara , Manica Umberto , Nagni Matteo 
Published: January 2025

Agenesis, or congenital absence of one or more dental elements, is one of the most frequently occurring craniofacial disorders in humans and is a clinical problem that compromises aesthetics and dental function from an early age. It is a condition that can involve both deciduous and permanent dentition, with contextually different prognoses and treatment solutions.
In both cases, the clinical management of this issue involves a multi-disciplinary approach designed to cover the comprehensive dental needs of patients with agenesis. Among the elements of the permanent dentition less commonly affected by this malformation are the lower lateral incisors, whose absence may be rare but, at the same time, aesthetically and functionally debilitating for the patient.
Aim: The current study presents a review of the existing literature regarding the prevalence, etiology, and classification of the various clinically detectable dental agenesis, with a focus especially directed toward absent mandibular lateral incisors and possible clinical dental management to resolve the problem. This article’s description of a case report aims to outline a possible aesthetic rehabilitation approach in the presence of these rare cases of agenesis and then present the clinical results obtained through implant-prosthetic rehabilitation combined with orthodontic therapy.
Interceptive orthodontic treatment with elastodontic appliance for open bite in early childhood: a case series
Authors: Vena Filippo , D'Amico Giorgia , Cardarelli Filippo , Cianetti Stefano , Severino Marco 
Published: January 2025

This case series explores the effectiveness of interceptive orthodontic treatment using A.M.C.O.P elastodontic appliances for open bite correction in early childhood. The study included three patients aged 3-5 years with primary dentition open bite and associated oral habits, treated at the Odontostomatological Centre, University of Perugia. Treatment utilized A.M.C.O.P Bio-Activators, tailored for early intervention, leveraging light and biological elastic forces to guide jaw growth and correct dental alignment.
The study highlights the role of timely intervention using A.M.C.O.P Bio-Activators in managing malocclusions, demonstrating significant improvements in occlusion and functional disorders. Early treatment with these devices not only corrects open bite efficiently but also reduces the need for future orthodontic interventions, emphasizing the importance of accurate diagnosis and patient compliancein achieving lasting results.
A Pterygoid Implants in severe posterior maxillary atrophy: a case report
Authors: Iacomino Enzo , Rastelli Sofia , Capogreco Mario , Severino Marco , Gallottini Sofia Germana , Grivetto Fabrizio 
Published: January 2025

A good clinician must be able to make a diagnosis and on the basis of this identify the ideal treatment plans. The choice of treatment plan depends on both the patient's needs and the clinical and anatomical conditions. Therefore, in order to have multiple alternatives it is advisable to enlarge clinical acknowledgement. The placement of pterygoid implants to rehabilitate the posterior maxillae region is little used. Pterygoid implants are non-traditional dental implants, longer than normal (up to 25mm), which are inserted into the pterygoid process of the sphenoid bone. The pterygoid bone is a very hard and compact bone and guarantees dental implant high primary stability and a safer immediate loading. To obtain a better stability of dental rehabilitation, pterygoid implants can also be used in combination with traditional dental implants and / or zygomatic implants or trans-sinus tilted implants.
This technique is ideal because it has better bone quality than tuber maxillae, the patient can count teeth down to the second molar, immediate loading is possible, treatment times are limited and it is a predictable treatment.
The presentation of this case report aims to highlight how and why it is necessary to consider the option of inserting pterygoid implants as a valid alternative.
Clinical and histomorphometric comparison of autologous dentin graft versus a deproteinized bovine bone graft for Socket Preservation
Authors: Meme Lucia , Grilli Filippo , Pizzolante Tommaso , Capogreco Mario , Bambini Fabrizio , Sampalmieri Francesco , Mummolo Stefano 
Published: January 2025

Dentin has been a significant focus of research due to its potential as a bone substitute, owing to its higher mineral content than any material derived from bone. Additionally, dentin shares two key similarities with autologous bone: it is both osteocompatible and osteoconductive, providing a physical framework for the deposition of new bone. This comparative study assessed the osteoinductive and osteoconductive capabilities of various materials commonly used in “socket preservation” or alveolar ridge preservation. The results showed that the autologous dentin matrix and bovine-derived xenografts (Bio-oss) achieved superior bone regeneration, with a greater volume of newly formed bone (measured by the BV/TV parameter) and reduced fibrous bone, which has undesirable characteristics for implant biomechanics.
Triple M overlap syndrome following pembrolizumab treatment: importance of multidisciplinary approach
Authors: Gómez Lucía , Lozano Teresa , Jovani Vega , Martínez-Banaclocha Natividad 
Published: January 2025

The increasing use of immune checkpoint inhibitors in clinical practice is associated with a broad spectrum of immune-related adverse events, such as cardiac, rheumatological and neurological toxicities. Myocarditis is a life-threatening complication, and the concurrent development of myocarditis, myositis and/or myasthenia leads to difficulties in diagnosis, management and treatment. We describe a case presenting with this triple M overlap syndrome following pembrolizumab treatment.A man in his 80s with a background of chronic ischaemic heart disease, receiving pembrolizumab as first-line treatment for microsatellite instability locally advanced gastric cancer, presented after the second dose of treatment with muscle weakness, binocular diplopia and left ptosis. Elevated transaminases, creatine kinase and high-sensitivity troponin-T levels were revealed. ECG monitoring showed the development of an atrioventricular block, needing a temporary pacemaker. Immune-related myocarditis, myasthenia and myositis were suspected. High-dose corticosteroids were administered without clinical benefit, so an escalation of immunosuppression was needed, using infliximab and immunoglobulins.
Predicting 90-day return to the emergency department in orthopaedic trauma patients in the Southeastern USA: a machine-learning approach
Authors: Valan Bruno , Therien Aaron , Peairs Emily , Ayehu Solomon , Taylor Joshua , Zeng Daniel , Olson Steven , Reilly Rachel , Pean Christian , DeBaun Malcolm 
Published: January 2025

IntroductionReturn-to-acute-care metrics, such as early emergency department (ED) visits, are key indicators of healthcare quality, with ED returns following surgery often considered avoidable and costly events. Proactively identifying patients at high risk of ED return can support quality improvement efforts, allowing interventions to target vulnerable patients. With its predictive capabilities, machine learning (ML) has shown potential in forecasting various clinical outcomes but remains underutilised in orthopaedic trauma. This study uses a random forest model to predict 90-day ED return in orthopaedic trauma patients, aiming to identify high-risk individuals and elucidate risk factors associated with returns. This study hypothesised that a highly accurate model could be developed to predict patients at high risk of ED return within 90 days of surgery.PurposeTo develop and validate an ML model that predicts 90-day ED returns after orthopaedic trauma surgery using input data readily available in the electronic health record.MethodsThis is a retrospective model development and validation study. The study used data from a registry that includes information on all orthopaedic surgeries conducted at a level 1 academic medical centre. Patients who underwent orthopaedic trauma between 1 January 2017 and 1 March 2023 were identified using common procedural terminology code. The model used demographic, comorbid and perioperative variables. Return to the ED was captured as a binary outcome. Model performance was evaluated using the area under the receiver operator curve (AUROC).ResultsA total of 12 069 patients met the inclusion criteria. Patients were predominantly female (53%) and white (70%), with a median age of 55. The 90-day ED return rate was 14% (table 1). The random forest model identified body mass index, distance from the patient’s residence to the hospital, age, length of hospital stay and complexity of procedure (work relative value unit) as significant predictors of ED return, each accounting for greater than 10% of the total importance across all features in the model (table 2). Further, the model displayed strong discrimination of patients returning to the ED (AUROC=0.74) (figure 1).ConclusionsThe random forest model demonstrated predictive discrimination of 90-day ED returns. Critical predictors such as patient distance from the hospital suggest considering geographical and socioeconomic factors in postdischarge care planning. Operational factors such as length of stay or complexity of the procedure also predicted return to the ED. The study lays the groundwork for future predictive models in clinical decision-making and healthcare resource utilisation.Level of evidenceLevel III, retrospective model development and validation study.
Retrospective multicenter analysis of the Trenza Embolization Device for endovascular therapy of intracranial aneurysms: initial results and short-term follow-up
Authors: Wolf Marcel N , Valvassori Luca , Gioppo Andrea , Rautio Riitta , Hoeltje Jan , Schramm Peter , Jovanovic Ivan , Ozretic David , Buhk Jan-Hendrik , Allegretti Luca , Ernst Marielle , Brockmann Marc A , Othman Ahmed E 
Published: January 2025

BackgroundIntrasaccular devices are increasingly used in endovascular therapy of intracranial aneurysms, in particular wide-necked and ruptured aneurysms. The Trenza Embolization Device (TED) is an innovative intrasaccular device for medium- to large-sized aneurysms. Currently, literature about the TED is scarce.MethodsIn eight participating European centers, 25 aneurysms (3 ruptured) in 25 patients (18 females, mean age 62.4 years) treated with the TED outside the currently recruiting prospective, post-market, multicenter study were included in this retrospective, multicenter analysis. Primary endpoints for clinical safety were the absence of stroke and death. Primary endpoint for technical success was implantation of TED without necessity of adjunct stenting. Primary and secondary endpoints for efficacy were adequate angiographic occlusion according to the Modified Raymond–Roy Classification (MRRC) immediately after the procedure and at first follow-up (FU).ResultsStent-assistance was required in two cases. Thus primary endpoint for technical success was reached in 23/25 (92%) cases. With one symptomatic thrombotic event, primary safety endpoint was reached in 24/25 (96%) cases. At the end of the procedure, complete occlusion (MRRC I) was achieved in 12/25 (48%), and a small residual neck (MRRC II) remained in 13/25 (52%) cases. In 19 cases FU (mean 6 months) was available, showing adequate occlusion in 17/19 (89.5%) cases (MRRC I in 8/19 and stable MRRC II in 9/19 cases) and relevant reperfusion MRRC IIIa with indication to retreatment in 2/19 (10.5%) cases.ConclusionsThe results of this first retrospective, multicenter experience with the TED appear promising. Further prospective, multicenter studies with larger patient cohorts, as well as long-term FU, are required.
Predictive value of myositis antibodies: role of semiquantitative classification and positivity for more than one autoantibody
Authors: Kerola Anne M , Pietikäinen Annukka , Barantseva Julia , Pajander Annaleena , Hänninen Arno 
Published: January 2025

ObjectivesWe assessed the positive predictive value (PPV) of 17 myositis antibodies for having a diagnosis of myositis and other myositis-spectrum conditions (interstitial lung disease (ILD), connective tissue diseases (CTD), malignancy) and evaluated the impact of semiquantitative classification and antibody overlap on the PPVs.Materials and methodsWe retrospectively identified 1068 individuals ≥18 years who tested positive for ≥1 antibody in the EUROLINE myositis line blot assay or positive for anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) in an ELISA-based test between 2015 and 2020 in 15 out of the 20 hospital districts in Finland. We extracted clinical diagnoses from the Care Register for Health Care between January 2013 and June 2022.ResultsThe PPV for a myositis diagnosis (ever during data collection) was highest for anti-HMGCR antibodies (94%), followed by anti-MDA5, anti-Jo-1 and anti-TIF1-γ (49–54%). Regarding other myositis antibodies, 18–42% of cases had myositis. Anti-synthetase antibodies, anti-MDA5, anti-PM-Scl100, anti-SAE1 and anti-Ro52 had a PPV for ILD of 25–47%. A PPV for CTD was highest for anti-Ro52 (57%). The PPV for malignancy was highest for anti-TIF1-γ (38%), followed by anti-PL-7 (32%). Stronger antibody band intensity was associated with higher PPVs for myositis and CTD but not for ILD or malignancies. Simultaneous positivity for ≥2 antibodies compared with single antibody was associated with higher PPVs for myositis, CTD and ILD.ConclusionThe PPV of myositis antibodies for diagnoses of myositis or other myositis spectrum diseases vary considerably between individual autoantibodies. Higher PPVs can be expected with stronger band intensities and with the presence of ≥2 overlapping myositis antibodies.
Prevalence and potential implications of HPV infection in transgender women with gender reaffirming genital surgery: a systematic literature review and meta-analysis
Authors: Elasifer Hana , Toledo Gabriel , Graham Catriona , Cuschieri Kate 
Published: January 2025

BackgroundHuman papillomavirus (HPV) is a common infection of the anogenital tract. Although most infections clear, persistent infections with oncogenic types can predispose to cancer. While the natural history of anogenital HPV infection in cisgendered women is relatively well understood, there are significant knowledge gaps regarding HPV prevalence and clinical implications of genital HPV infection in transgender women (TGW) with neovagina(s).MethodsA systematic review, including meta-analysis, of studies available in the literature with data on HPV prevalence in TGW with neovaginas was performed. Additionally, a narrative analysis of the clinical manifestations of genital HPV infections in TGW with neovagina(s) was performed.Results21 studies were included; six focused on the prevalence of HPV in TGW, and data were pooled in a meta-analysis of prevalence; 15 were case reports/series, which were included in a narrative analysis of clinical implications. The meta-analysis showed the prevalence of genital HPV in TGW with neovaginas was 15% (95% CI 9% to 21%). The most frequently detected HPV type was HPV 16. 18 TGW were included in case reports/series and the median age was 42; 12 presented with condylomata acuminata and six had squamous carcinoma.ConclusionData on genital HPV prevalence in TGW with neovaginas are sparse, with many studies having small denominators. We report higher HPV prevalence compared with cisgendered women. Symptomatic genital HPV infection in TGW with neovaginas was largely associated with benign condylomata, although some carcinoma was detected. Future longitudinal studies are required to elucidate the clinical impact of genital HPV infection and examine its implications in TGW with neovaginas in order to inform prevention and management strategies.