bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advances in Ferroelectric‐Enhanced Low‐Dimensional Optoelectronic Devices
Authors: Iqbal Muhammad Ahsan , Xie Haowei , Qi Lu , Jiang Wei‐Chao , Zeng Yu‐Jia 
Published: January 2023

AbstractFerroelectric (FE) materials, including BiFeO3, P(VDF‐TrFE), and CuInP2S6, are a type of dielectric material with a unique, spontaneous electric polarization that can be reversed by applying an external electric field. The combination of FE and low‐dimensional materials produces synergies, sparking significant research interest in solar cells, photodetectors (PDs), nonvolatile memory, and so on. The fundamental aspects of FE materials, including the origin of FE polarization, extrinsic FE materials, and FE polarization quantification are first discussed. Next, the state‐of‐the‐art of FE‐based optoelectronic devices is focused. How FE materials affect the energy band of channel materials and how device structures influence PD performance are also summarized. Finally, the future directions of this rapidly growing field are discussed.
A Spiky Silver‐Iron Oxide Nanoparticle for Highly Efficient Targeted Photothermal Therapy and Multimodal Imaging of Thrombosis
Authors: Vazquez‐Prada Karla X. , Moonshi Shehzahdi S. , Wu Yuao , Akther Fahima , Tse Brian W.C. , Sokolowski Kamil A. , Peter Karlheinz , Wang Xiaowei , Xu Gordon , Ta Hang Thu 
Published: January 2023

AbstractThrombosis and its complications are responsible for 30% of annual deaths. Limitations of methods for diagnosing and treating thrombosis highlight the need for improvements. Agents that provide simultaneous diagnostic and therapeutic activities (theranostics) are paramount for an accurate diagnosis and rapid treatment. In this study, silver‐iron oxide nanoparticles (AgIONPs) are developed for highly efficient targeted photothermal therapy and imaging of thrombosis. Small iron oxide nanoparticles are employed as seeding agents for the generation of a new class of spiky silver nanoparticles with strong absorbance in the near‐infrared range. The AgIONPs are biofunctionalized with binding ligands for targeting thrombi. Photoacoustic and fluorescence imaging demonstrate the highly specific binding of AgIONPs to the thrombus when functionalized with a single chain antibody targeting activated platelets. Photothermal thrombolysis in vivo shows an increase in the temperature of thrombi and a full restoration of blood flow for targeted group but not in the non‐targeted group. Thrombolysis from targeted groups is significantly improved (p < 0.0001) in comparison to the standard thrombolytic used in the clinic. Assays show no apparent side effects of AgIONPs. Altogether, this work suggests that AgIONPs are potential theranostic agents for thrombosis.
Catalyst‐Accelerated Circular Cascaded DNA Circuits: Simpler Design, Faster Speed, Higher Gain
Authors: Wang Jiaoli , Fu Xiaoxiao , Liu Shiyuan , Liu Ruiting , Li Jing , Wang Kemin , Huang Jin 
Published: January 2023

AbstractDNA cascaded circuits have great potential in detecting low abundance molecules in complex biological environment due to their powerful signal amplification capability and nonenzymatic feature. However, the problem of the cascaded circuits is that the design is relatively complex and the kinetics is slow. Herein, a new design paradigm called catalyst‐accelerated circular cascaded circuits is proposed, where the catalyst inlet is implanted and the reaction speed can be adjusted by the catalyst concentration. This new design is very simple and only requires three hairpin probes. Meanwhile, the results of a series of studies demonstrate that the reaction speed can be accelerated and the sensitivity can be also improved. Moreover, endogenous mRNA can also be used as a catalyst to drive the circuits to amplify the detection of target miRNA in live cells and in mice. These catalyst‐accelerated circular cascaded circuits can substantially expand the toolbox for intracellular low abundance molecular detection.
Construction of Bimetallic Heterojunction Based on Porous Engineering for High Performance Flexible Asymmetric Supercapacitors
Authors: Gong Shen‐Gen , Li Yan‐Fei , Su Yang , Li Bing , Yang Guo‐Duo , Wu Xing‐Long , Zhang Jing‐Ping , Sun Hai‐Zhu , Li Yunfeng 
Published: January 2023

AbstractIt remains a great challenge to design and manufacture battery‐type supercapacitors with satisfactory flexibility, appropriate mechanical property, and high energy density under high power density. Herein, a concept of porous engineering is proposed to simply prepare two‐layered bimetallic heterojunction with porous structures. This concept is successfully applied in fabrication of flexible electrode based on CuO‐Co(OH)2 lamella on Cu‐plated carbon cloth (named as CPCC@CuO@Co(OH)2). The unique structure brings the electrode a high specific capacity of 3620 mF cm−2 at 2 mA cm−2 and appropriate mechanical properties with Young's modulus of 302.0 MPa. Density functional theory calculations show that porous heterojunction provides a higher intensity of electron state density near the Fermi level (E–Ef = 0 eV), leading to a highly conductive CPCC@CuO@Co(OH)2 electrode with both efficient charge transport and rapid ion diffusion. Notably, the supercapacitor assembled from CPCC@CuO@Co(OH)2//CC@AC shows high energy density of 127.7 W h kg−1 at 750.0 W kg−1, remarkable cycling performance (95.53% capacity maintaining after 10 000 cycles), and desired mechanical flexibility. The methodology and results in this work will accelerate the transformative developments of flexible energy storage devices in practical applications.
Diagnosis of Unruptured Intracranial Aneurysm by High‐Performance Serum Metabolic Fingerprints
Authors: Su Jiabin , Cao Jing , Yang Heng , Xu Wei , Liu Wanshan , Wang Ruimin , Huang Yida , Wu Jiao , Gao Xinjie , Weng Ruiyuan , Pu Jun , Liu Ning , Gu Yuxiang , Qian Kun , Ni Wei 
Published: January 2023

AbstractUnruptured intracranial aneurysm (UIA) is a high‐risk cerebrovascular saccular dilatation, the effective medical management of which depends on high‐performance diagnosis. However, most UIAs are diagnosed incidentally during neurovascular imaging modalities, which are time‐consuming and harmful (e.g., radiation). Serum metabolic fingerprints is a promising alternative for early diagnosis of UIA. Here, nanoparticle enhanced laser desorption/ionization mass spectrometry is applied to obtain high‐performance UIA‐specific serum metabolic fingerprints. Diagnostic performance with an area‐under‐the‐curve (AUC) of 0.842 (95% confidence interval (CI): 0.783‐0.891) is achieved by the constructed machine learning (ML) model, including ML algorithm selection and feature selection. Lactate, glutamine, homoarginine, and 3‐methylglutaconic acid are identified as the metabolic biomarker panel, which showed satisfactory diagnosis (AUC of 0.812, 95% CI: 0.727‐0.897) and effective growth risk assessment (p<0.05, two‐tailed t‐test) of UIAs. This work aims to promote the diagnostics of UIAs and metabolic biomarker screening for medical management.
Ionic Liquids as Organocatalysts and Solvents for Lignocellulose Reactions
Authors: Suzuki Shiori , Takahashi Kenji 
Published: January 2023

AbstractIonic liquids (ILs) are the only media that can allow the homogeneous organocatalytic reactions of lignocellulosic biomass (lignocellulose), since the designability of their cations and anions offers the dual functions of solubility and catalytic activity. This review provides an account of our recent achievements in the organocatalytic approaches for converting lignocellulose into polymer materials based on the principles of IL design that we have originally established. These methodologies include the simple and mild chemical modification of cellulose and lignin under high conversions, with high selectivity, and/or with efficient atom economy. Similar reactions and subsequent fractionation processes are applied to lignocellulose, and a highly productive reaction system is developed using a twin‐screw extruder that is specific to the IL media.
Circ‐N4BP2L2 enhances mitochondrial function in non‐small cell lung cancer cells through regulating the miR‐135a‐5p/ARL5B axis
Authors: Shi Hongyang , Ji Yuqiang , Zhang Yonghong , Wang Yu , Li Wei 
Published: January 2023

AbstractNon‐small cell lung cancer (NSCLC) is the main histological subtype of lung cancer with a high incidence and mortality. Circular RNAs (circRNAs) exert vital functions in various cancers by acting as a sponge of miRNAs to abolish their inhibitory effect on target genes. This study aims to explore the biological function of circRNA NEDD4 binding protein 2 like 2 (circ‐N4BP2L2) in NSCLC. We found that circ‐N4BP2L2 was upregulated in NSCLC tissues and cells by using RT‐qPCR. A549 cells were transfected with pcDNA‐circN4BP2L2 or sh‐circN4BP2L2 to obtain circN4BP2L2‐overexpressed or ‐silenced cells, and then cell proliferation, invasion and apoptosis were determined. The results showed that knockdown of circ‐N4BP2L2 repressed cell proliferation, invasion as well as mitochondrial function, and promoted cell apoptosis; while overexpression of circ‐N4BP2L2 resulted in the opposite results. Mechanistically, the targeting correlations between miR‐135a‐5p and circ‐N4BP2L2 or ADP‐ribosylation factorlike 5B (ARL5B) were confirmed by using dual luciferase reporter, RNA pull‐down and RNA immunoprecipitation assays. In addition, we found that circ‐N4BP2L2 could promote the expression of ARL5B by serving as a sponge of miR‐135a‐5p. Moreover, rescue assays revealed that silencing miR‐135a‐5p or overexpressing ARL5B was able to abate the effects of circ‐N4BP2L2 knockdown on malignant phenotypes and mitochondrial function of A549 cells. Finally, tumorigenicity assay demonstrated that circ‐N4BP2L2 facilitated NSCLC tumor growth in vivo. Taken together, circ‐N4BP2L2 enhanced NSCLC progression via the miR‐135a‐5p/ARL5B axis, which may provide a novel therapeutic target of NSCLC.
Meta‐QTL analysis and in‐silico transcriptome assessment for controlling chlorophyll traits in common wheat
Authors: Guo Kaiqi , Chen Tao , Zhang Peipei , Liu Yuan , Che Zhuo , Shahinnia Fahimeh , Yang Delong 
Published: January 2023

AbstractChlorophyll is an important plant molecule for absorbing light and transferring electrons to produce energy for photosynthesis, which has a significant impact on crop yield. To identify quantitative trait loci (QTL) controlling chlorophyll traits in wheat (Triticum aestivum L.), a comprehensive meta‐analysis of 411 original QTLs for six chlorophyll traits was performed, including the evolution of soil plant analysis development (SPAD), chlorophyll content index (CCI), chlorophyll a content (Chla), chlorophyll b content (Chlb), chlorophyll content (Chl), and ratio of chlorophyll a to b (Chla/b), derived from 41 independent experiments conducted over the past two decades. Fifty‐six consensus meta‐QTLs (MQTLs) were detected, unevenly distributed on chromosomes 1A, 1B, 2A, 2B, 2D, 3B, 3D, 4B, 4D, 5A, 5D, 6A, 6D, 7B, and 7D. The confidence interval (CI) of the identified MQTLs was 0.18 to 15.07 cM, with an average of 5.74 cM, and 3.17‐times narrower than that of the original QTLs. A total of 30 MQTLs were aligned with marker‐trait associations (MTAs) reported in genome‐wide association studies (GWAS) for chlorophyll traits in wheat. Based on MQTL‐flanking marker information and homology analyses combined with RNA‐seq data, 136 putative candidate genes were identified in MQTL regions, involved in porphyrin metabolism, photosynthesis, terpene biosynthesis, glyoxylate and dicarboxylate metabolism, and secondary metabolites. The results of this study contribute to the understanding of the genetic basis for controlling chlorophyll traits and can be used in breeding wheat with high photosynthetic efficiency.
Ageing and Reserves
Authors: Ihle Andreas , Gouveia Élvio R. , Gouveia Bruna R. , Orsholits Dan , Kliegel Matthias 
Published: January 2023

AbstractIn this chapter we elaborate on our conceptual view on vulnerability being the result of insufficient reserve build-up across the life course in various domains (e.g., cognitive reserve and relational reserve). Specifically, we propose that certain individuals are more vulnerable (than other, less vulnerable individuals) to impairments in human functioning because of insufficient reserves accumulated over their life course, which consequently exposes those individuals to greater difficulty to deal with threatening situations in old age in order to offset or prevent negative outcomes. To illustrate our novel perspective with empirical examples, we focus on cognitive and relational reserve domains and their role for cognitive health and well-being as aging outcomes. First, we elaborate on the build-up of these reserve domains across the life course, with a special focus on inter-individual differences in the pathways of reserve accumulation. Second, we concentrate on the role of reserves for human functioning in different groups of vulnerable individuals in old age. Third, we elaborate on the interplay of different reserve domains and their potential joint effects on aging outcomes. Finally, we conclude with an outlook for future research.
On the Sociohistorical Construction of Social and Economic Reserves Across the Life Course and on Their Use in Old Age
Authors: Oris Michel , Baeriswyl Marie , Duvoisin Aline , Gabriel Rainer , Girardin Myriam , Henke Julia , Masotti Barbara , Tholomier Aude , Widmer Eric 
Published: January 2023

AbstractCoherently with the life course perspective that studies individual life trajectories embedded in sociohistorical changes, this chapter offers a synthesis on the long-term dynamics of vulnerabilities in old age that are associated with a deficit of reserves. In a first time, we investigate how economic, social and health reserves have been unevenly constructed across long lives. The impact of social stratification in the early stage of life, the institutionalization of the life courses and the process of accumulating (dis)advantages are confronted. In a second time, we show how the results of those life course dynamics, the unequal distribution of reserves older adults have to cope with aging, changed during the last 40 years. Undeniable progresses also resulted in new inequalities, or the accentuation of older ones. Third, challenging the classical perspectives of political economy of ageing and social gerontology, we show that depletion is not a linear process but that social inequalities and life accidents play a role. Moreover, coping mechanisms are considered since they tend to be based on reserves’ activation while preserving a level of reserves, for further ageing challenges.
Mixed Method Approaches for Data Collection in Hard-to-reach Populations
Authors: Perrenoud Marc , Bataille Pierre , Elcheroth Guy 
Published: January 2023

AbstractVulnerable populations are often hard to reach. Ethnic or sexual minorities, people living at the margins of social, economic, educational or occupational systems and structures are frequently experiencing precariousness, dealing with unsure material and symbolic resources. However, those populations are most of the time concealed and unseen in big statistical surveys, precisely as they stand at the edges of main social groups. Therefore, it seems very worthwhile to develop specific tool to conduct surveys on those most vulnerable populations, and mixed methods approaches are particularly relevant for that purpose. In this chapter, we will mainly rely on the Musicians LIVES survey conducted between 2012 and 2016 on “ordinary musicians” (nor rich or famous) in French-speaking Switzerland. From the sampling method to the data collection, we crossed quantitative and qualitative approaches in order to get significant and accurate results on a very informal occupational space. The chapter will be enhanced by different example and cases from other surveys conducted within the NCCR LIVES over the last decade.
Combining Data Collection Modes in Longitudinal Studies
Authors: Roberts Caroline , Voorpostel Marieke 
Published: January 2023

AbstractTechnological advances over the past two decades have substantially changed the range of data collection methods available to survey researchers. Web-based surveys have gained in popularity as increasing Internet penetration rates improve their coverage potential for general population research. Nevertheless, they still systematically exclude certain subgroups—e.g., those without Internet access or those less able (or motivated) to complete a survey questionnaire on their own. A popular solution to this problem is to use other modes of data collection for those who cannot participate online. However, whilemixed modesurveys can be effective at reducing selection errors, measurements obtained from different modes may not be comparable, particularly when it comes to sensitive topics. The fact that measurement and selection errors are confounded poses challenges for researchers analysing mixed mode data, and in a longitudinal setting, has implications for studying changes over time. In this chapter, we discuss these challenges in the context of longitudinal studies designed to measure indicators of vulnerability, and illustrate them with a synthesis of findings from our own research relating to (1) the effects of combining modes on response rates and therepresentativenessof survey samples and (2) effects formeasurementcomparability.
Positive and Negative Spillover Effects: Managing Multiple Goals in Middle Adulthood
Authors: Schüttengruber Victoria , Krings Franciska , Freund Alexandra M. 
Published: January 2023

AbstractBoth in the research literature as well as in popular media, the topic of “work-life” balance receives much attention, particularly for the age group of middle-aged adults. There is evidence for both, positive and negative spillover effects across life domains. This chapter provides a theoretical and empirical overview of the different types of inter-domain relationships, concepts of boundary management, and models of spillover effects on health and well-being. Adopting a lifespan perspective, we review the literature on spillover effects by focusing on multiple goal pursuit in the life domains of work, family, and leisure in middle adulthood. During this “rush hour” of life, middle-aged adults face the challenge of managing their scarce resources (e.g., time, energy) in order to achieve a successful “work-life balance.” Accordingly, we present empirical studies addressing the interplay between goal pursuit, boundary management, inter-domain conflict and facilitation, as well as spill- and crossover effects at the work-family interface. In addition, this chapter considers both exhaustion and recovery as key outcomes of spillover effects across life domains and highlights recommendations for boundary management in middle adulthood. Finally, this chapter outlines promising routes for future research on spillover effects between work, family, and leisure.
Wash-in leptogenesis after axion inflation
Authors: Domcke Valerie , Kamada Kohei , Mukaida Kyohei , Schmitz Kai , Yamada Masaki 
Published: January 2023

Abstract
CP violation and the violation of baryon-minus-lepton number B−L do not necessarily have to occur simultaneously in order to accomplish successful leptogenesis. Instead, it suffices if new CP-violating interactions at high energies result in primordial charge asymmetries, which are then reprocessed into a nonvanishing B−L asymmetry by right-handed neutrinos (RHNs) at lower energies. In this paper, we study this novel mechanism known as wash-in leptogenesis, utilizing axion inflation as the source of high-scale CP violation. We specifically consider axion inflation coupled to the Standard Model hypercharge sector, which results in the dual production of hypermagnetic helicity and fermionic charge asymmetries. Although the survival of these charges is endangered by sphaleron processes, magnetic diffusion, and the chiral plasma instability, we find a large range of viable scenarios. We consistently account for RHN flavor effects and coherence among the Standard Model lepton flavors across a wide range of RHN masses. We find a lower bound of 105···9 GeV on the mass of the lightest RHN involved in wash-in leptogenesis, depending on the onset of turbulence in the chiral plasma and the Hubble scale of inflation. Our model is representative of a broader class of new leptogenesis scenarios and suggests interesting observational signatures with regard to intergalactic magnetic fields, primordial black holes, and gravitational waves.
The minus sign in the first law of de Sitter horizons
Authors: Banihashemi Batoul , Jacobson Ted , Svesko Andrew , Visser Manus 
Published: January 2023

Abstract
Due to a well-known, but curious, minus sign in the Gibbons-Hawking first law for the static patch of de Sitter space, the entropy of the cosmological horizon is reduced by the addition of Killing energy. This minus sign raises the puzzling question how the thermodynamics of the static patch should be understood. We argue the confusion arises because of a mistaken interpretation of the matter Killing energy as the total internal energy, and resolve the puzzle by introducing a system boundary at which a proper thermodynamic ensemble can be specified. When this boundary shrinks to zero size the total internal energy of the ensemble (the Brown-York energy) vanishes, as does its variation. Part of this vanishing variation is thermalized, captured by the horizon entropy variation, and part is the matter contribution, which may or may not be thermalized. If the matter is in global equilibrium at the de Sitter temperature, the first law becomes the statement that the generalized entropy is stationary.
Safety of Surgery Among Asymptomatic SARS‐CoV‐2 PCR‐Positive Patients: A Single‐Center Retrospective Cohort Study
Authors: Aydın Ozlem , Ergen Pınar , Vahaboglu Haluk 
Published: January 2023

AbstractBackgroundScreening with SARS‐CoV‐2 PCR tests is recommended for all patients undergoing surgery under general anesthesia, and elective surgery is deferred for positive patients. This study evaluated the outcomes of asymptomatic PCR‐positive patients who underwent general anesthesia and surgery.MethodsPatient data were collected from the hospital records of patients who underwent surgery between January 2021 and May 2022. Asymptomatic patients with a positive PCR test between 7 days before and 5 days after surgery were compared with controls. The cases were propensity score‐matched with a 1:2 ratio to the controls. All‐cause in‐hospital mortality was the primary outcome of the study.ResultsA total of 217 asymptomatic PCR‐positive patients were matched to 434 controls. In multivariate analysis, PCR‐positive test results were not associated with mortality (log(OR) (95%CIs), p; 0.86 (− 0.13, 1.9), 0.09). Age and ASA score (>3) were the most significant risk factors associated with mortality.ConclusionThis study found that surgery among asymptomatic PCR‐positive patients was not associated with increased mortality.