bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Brain Pathologies on Spatiotemporal Gait Parameters in Patients with Mild Cognitive Impairment
Authors: Lindh-Rengifo Magnus , Jonasson Stina B. , Ullén Susann , Palmqvist Sebastian , van Westen Danielle , Stomrud Erik , Mattsson-Carlgren Niklas , Nilsson Maria H. , Hansson Oskar 
Published: September 2023

Background: Impaired gait can precede dementia. The associations between gait parameters and brain pathologies are therefore of interest. Objective: To explore how different brain pathologies (i.e., vascular and Alzheimer’s) are associated with specific gait parameters from various gait components in persons with mild cognitive impairment (MCI), who have an increased risk of developing dementia. Methods: This cross-sectional study included 96 patients with MCI (mean 72, ±7.5 years; 52% women). Gait was evaluated by using an electronic walkway, GAITRite®. Four gait parameters (step velocity variability; step length; step time; stance time asymmetry) were used as dependent variables in multivariable linear regression analyses. Independent variables included Alzheimer’s disease pathologies (amyloid-β and tau) by using PET imaging and white matter hyperintensities (WMH) by using MRI. Covariates included age, sex, comorbidities (and intracranial volume in analyses that includedWMH). Results: Increased tau-PET (Braak I–IV region of interest [ROI]) was associated with step velocity variability (standardized regression coefficient, β= 0.383, p < 0.001) and step length (β= 0.336, p < 0.001), which remained significant when using different Braak ROIs (I-II, III-IV, V-VI). The associations remained significant when adjusting for WMH ( p < 0.001). When also controlling for gait speed, tau was no longer significantly ( p = 0.168) associated with an increased step length. No significant associations between gait and Aβ-PET load or WMH were identified. Conclusions: The results indicate that one should pay specific attention to assess step velocity variability when targeting single task gait in patients with MCI. Future studies should address additional gait variability measures and dual tasking in larger cohorts.
Excessive Sedentary Time Is Associated with Cognitive Decline in Older Patients with Minor Ischemic Stroke
Authors: Liang Hongtao , Yin Xiang , Chen Tian , Zhang Yan , Zhang Qin , Lin Jie , Yin Huan , Tang Jinghua , He Yingyi , Xia Ping , Zhu Yongping , Li Haihua , Mo Yongbiao , Li Yongyong , Wang Ying , Yang Xiao , Hu Zicheng 
Published: September 2023

Background: Cognitive impairment is commonly seen after acute ischemic stroke (AIS). Sedentary behaviors increase the risk of dementia among community dwelling population. Objective: This study aims to investigate the association of sedentary behaviors with poststroke cognitive impairment among older adults with minor AIS. Methods: This cohort study recruited 594 older subjects with minor AIS from three hospitals in China during February 1, 2016, and December 31, 2018. Participants were followed up for two years and the sedentary time per day was self-reported at the end of follow-up. Cognitive functions were assessed by Mini-Mental State Examination (MMSE). Participants were categorized into the high and low sedentary time group according to the median sedentary time of the participants. Results: At two years of follow-up, the long sedentary time group had significantly lower MMSE scores than the short sedentary time group [median, (IQR): 21 (18 to 25) versus 22 (18 to 25), p = 0.368]. The long sedentary time group had a higher speed of cognitive decline than the short sedentary time group. Excessive sedentary time was associated with a higher risk of longitudinal cognitive decline (OR: 2.267, 95% CI: 1.594 to 3.225), adjusting for age, sex, education, body mass index, APOE genotype, comorbidities, symptoms of depression, anxiety, and insomnia, baseline MMSE scores and National Institute of Health Stroke Scale scores, cognitive therapy, and TOAST ischemic stroke subtypes. Conclusions: This study identified a possible link between sedentary behaviors and longitudinal cognitive decline among older patients with minor AIS, suggesting that reducing sedentary time might be helpful for preventing poststroke dementia.
Effects of a Physical Activity Program that Incorporates Exercises Targeting Balance, Strength, and Proprioception on Cognitive Functions and Physical Performance in Old Adults with Mild Cognitive Impairment
Authors: Boulares Ayoub , Fabre Claudine , Cherni Ala , Jdidi Hela , Gaied Chortane Sabri , Trompetto Carlo , Puce Luca , Bragazzi Nicola Luigi 
Published: September 2023

Background: Aging often leads to cognitive function decline, sensory structure deterioration, and musculoskeletal system weakening. This impacts postural control during static and dynamic activities like walking, increasing the fall risk among the elderly. Older adults with mild cognitive impairment (MCI) face an elevated fall risk and cognitive decline, magnifying the public health concern. Objective: This study aimed to explore solutions by investigating the effects of a multi-component physical activity program on cognitive and motor functions in MCI patients. Methods: Twenty-three participants were enrolled in the study and assigned into two groups: an intervention group ( n = 13; age = 85.7±5.5 years) and a control group ( n = 9; age = 85±6.7 years). The study spanned two months, with participants engaging in three 60-minute weekly physical exercise sessions. The intervention focused on improving proprioception, muscle strength, and balance. Results: Results demonstrated significant enhancements in physical performance, fall risk reduction, and balance ( p < 0.05). Various tests, including the timed up and go test, Unipedal Stance test, Tinetti test, Short Physical Performance Battery, and 6-minute walking test, indicated these improvements. Cognitive function was evaluated with the Mini-Mental State Examination, revealing non-significant progress ( p > 0.05). Predictive models for outcomes were developed using linear regression analysis during the follow-up stage. Conclusions: This study underscores the effectiveness of a multi-component physical activity program encompassing balance, proprioception, and muscle-strengthening exercises as a non-pharmaceutical approach in improving balance skills and playing a key role in mitigating the risk of falls among old adults with MCI.
Medial Temporal Lobe Tau Aggregation Relates to Divergent Cognitive and Emotional Empathy Abilities in Alzheimer’s Disease
Authors: Chow Tiffany E. , Veziris Christina R. , Mundada Nidhi , Martinez-Arroyo Alexis I. , Kramer Joel H. , Miller Bruce L. , Rosen Howard J. , Gorno-Tempini Maria Luisa , Rankin Katherine P. , Seeley William W. , Rabinovici Gil D. , La Joie Renaud , Sturm Virginia E. 
Published: September 2023

Background: In Alzheimer’s disease (AD), the gradual accumulation of amyloid-β (Aβ) and tau proteins may underlie alterations in empathy. Objective: To assess whether tau aggregation in the medial temporal lobes related to differences in cognitive empathy (the ability to take others’ perspectives) and emotional empathy (the ability to experience others’ feelings) in AD. Methods: Older adults ( n = 105) completed molecular Aβ positron emission tomography (PET) scans. Sixty-eight of the participants (35 women) were Aβ positive and symptomatic with diagnoses of mild cognitive impairment, dementia of the Alzheimer’s type, logopenic variant primary progressive aphasia, or posterior cortical atrophy. The remaining 37 (22 women) were asymptomatic Aβ negative healthy older controls. Using the Interpersonal Reactivity Index, we compared current levels of informant-rated cognitive empathy (Perspective-Taking subscale) and emotional empathy (Empathic Concern subscale) in the Aβ positive and negative participants. The Aβ positive participants also underwent molecular tau-PET scans, which were used to investigate whether regional tau burden in the bilateral medial temporal lobes related to empathy. Results: Aβ positive participants had lower perspective-taking and higher empathic concern than Aβ negative healthy controls. Medial temporal tau aggregation in the Aβ positive participants had divergent associations with cognitive and emotional empathy. Whereas greater tau burden in the amygdala predicted lower perspective-taking, greater tau burden in the entorhinal cortex predicted greater empathic concern. Tau burden in the parahippocampal cortex did not predict either form of empathy. Conclusions: Across AD clinical syndromes, medial temporal lobe tau aggregation is associated with lower perspective-taking yet higher empathic concern.
Exploring the Association Between Opioid Use Disorder and Alzheimer’s Disease and Dementia Among a National Sample of the U.S. Population
Authors: Qeadan Fares , McCunn Ashlie , Tingey Benjamin , Price Ron , Bobay Kathleen L , English Kevin , Madden Erin F. 
Published: September 2023

Background: Past research suggests associations between heavy alcohol use and later life dementia. However, little is known about whether opioid use disorder (OUD) and dementia share this association, especially among age groups younger than 65 years old. Objective: Examine the association between OUD and Alzheimer’s disease (AD) and dementia. Methods: Electronic health records between 2000 and 2021 for patients age 12 or older were identified in the Cerner Real-World database™. Patients with a prior diagnosis of dementia were excluded. Patients were followed for 1-10 years (grouped by one, three, five, and ten-year follow-up periods) in a matched retrospective cohort study. Cox proportional hazards regressions were used to estimate adjusted hazard ratios (aHRs) of incident AD/dementia stratified by age and follow-up group. Results: A sample of 627,810 individuals with OUD were compared to 646,340 without OUD. Individuals with OUD exhibited 88% higher risk for developing AD/dementia compared to those without OUD (aHR = 1.88, 95% CI 1.74, 2.03) within 1 year follow-up and 211% (aHR = 3.11, 95% CI 2.63, 3.69) within 10 years follow-up. When stratifying by age, younger patients (age 12-44) had a greater disparity in odds of AD/dementia between OUD and non-OUD groups compared with patients older than 65 years. Conclusions: Additional research is needed to understand why an association exists between OUD and AD/dementia, especially among younger populations. The results suggest that cognitive functioning screening programs for younger people diagnosed with OUD may be useful for targeting early identification and intervention for AD/dementia in particularly high risk and marginalized populations.
Sleep Disorders in Early-Onset Parkinsonism: A Population-Based Study
Authors: McCarter Stuart J. , Camerucci Emanuele , Mullan Aidan F. , Stang Cole D. , Turcano Pierpaolo , St. Louis Erik K. , Boeve Bradley F. , Savica Rodolfo 
Published: September 2023

Background: Sleep disturbances are common in parkinsonian disorders; however, whether sleep disorders affect individuals with early-onset parkinsonism and whether they differ from individuals with typical-onset parkinsonism is unknown. Objective: To compare the prevalence and incidence of sleep disorders before and after parkinsonian motor symptom onset between individuals with early onset parkinsonism (age ≤50 at motor symptom onset) and typical-onset parkinsonism (age >50 at motor symptom onset). Methods: We used a population-based, 1991 to 2015 incident-cohort study of parkinsonism including 38 patients with early-onset and 1,001 patients with typical-onset parkinsonism. Presence or absence and type of sleep disorder as well as the relationship between motor and sleep symptoms were abstracted from the medical records. Rates of sleep disorders before and after onset of parkinsonism were compared with logistic regression and Cox proportional hazards models. Results: The prevalence of sleep disorders prior to the onset of parkinsonism in early vs. typical parkinsonism (24% vs. 16% p = 0.19) and incidence of sleep disorders after parkinsonism onset (5.85 cases per 100 person-years vs. 4.11 cases per 100 person-years; HR 1.15 95% CI: 0.74–1.77) were similar between the two groups. Early-onset parkinsonism had a higher risk for developing post-motor insomnia compared with typical-onset parkinsonism (HR 1.73, 95% CI: 1.02–2.93); the risk for developing all other sleep disorders considered was similar between groups. Conclusion: Sleep disorders are common in individuals with early-onset parkinsonism and occur with similar frequency to those with typical-onset parkinsonism, except for insomnia, which was more frequent in the early-onset group.
Factors associated with Afghan household food security pre- and post-Taliban regime
Authors: Sadat Seyyed Amin Allah , Charvadeh Mohammad Reza Pakravan , Gholamrezai Saeed , Rahimian Mehdi , Lane Ginny , Béland Daniel , Koc Mustafa , Clark Nancy , Omidvar Nasrin , Sadeghi Rasoul , Vatanparast Hassan 
Published: September 2023

<p>To determine multifaceted determinants of household vulnerability to food insecurity in Afghanistan before and after the Taliban takeover, we randomly selected 555 households from 13 provinces, conducted in-person surveys, and applied the Household Food Insecurity Assess Scale (HFIAS) and Structural Equation Modeling (SEM). We collected data from January to April 2022. We observed an increase in both prevalence and severity of food insecurity among Afghan households after the Taliban takeover. Approximately, 98% and 70% of interviewed households were food insecure after and before the Taliban takeover, respectively. Similarly, households were more likely to be severely food insecure (81%) than before (40%). Our results showed that policy and political conditions contributed substantially to the food insecurity of Afghan households after the Taliban takeover. We recommend that the Taliban forces facilitate the presence of humanitarian organizations and NGOs to improve low-income households’ food security, especially for women and children. We also recommend that international organizations enhance their attempts to negotiate with the Taliban to ensure freedom for women. </p>
Film Viewing in Postwar Japan, 1945-1968: An Ethnographic Study
Authors: Coates Jennifer 
Published: September 2023

How can we understand what cinema means to others? One of the biggest issues in audience and reception studies is the ultimate unknowability of the processes going on in the mind and body of another person as they watch a film. This has implications for our understanding of how these processes contribute to meaning making, in relation to how viewers understand the events and images onscreen to relate to, inform, or contrast with their own lives and understandings of the world. This book approaches the question of viewers’ relationship to film from a different angle, asking instead what it means to engage discursively with one another through cinema.
Film Viewing in Postwar Japan draws from four years of interviews, participant observation, questionnaire surveys, and written communications with over 100 study participants in the Kansai region of Western Japan. This is an in-depth study of memories of cinema-going among the generations who regularly attended film theatres between 1945-1968, the peak period of production and cinema attendance in Japan.
Through investigating the role of film viewership, broadly conceived, in the formation of a postwar sense of self, the reader will benefit from rare access to the voices of grass-roots viewers, who often tell a different version of cinema history and its effects than that available in extant scholarship.
British Romanticism and Denmark
Authors: Duffy Cian 
Published: September 2023

British Romanticism and Denmark traces a multifaceted discourse about Denmark across a wide range of different areas of enquiry and genres of cultural productivity in late-eighteenth- and early-nineteenth-century Britain. In so doing, the book has a twofold purpose. First: to recover a significant but still largely-unfamiliar aspect of the cultural history of Britain during the Romantic period. Second, and by extension: to further scholarly understanding of Romanticism as a European phenomenon by exploring how two national Romantic traditions interacted across political and linguistic borders. British Romanticism and Denmark shows how the articulation in British Romantic-period writing of the idea of a ‘Northern’ cultural identity shared by Britain and Denmark, and rooted in the Classical Scandinavian past, played an important role in the emergence and development of Romanticism and Romantic nationalism in both countries.
Insights into the time course of evidentiality processing in Turkish heritage speakers using a self-paced reading task
Authors: Tokaç-Scheffer Suzan D. , Arslan Seçkin , Nickels Lyndsey 
Published: September 2023

IntroductionStudies with heritage language speakers (HLS) have often used offline measurements, investigating the post-interpretive effects which emerge after processing has been completed. Relatively few studies have investigated heritage language processing using time-sensitive methods that allow the collection of evidence regarding real-time language processing rather than post-interpretive judgments. Using a self-paced-reading paradigm, we aimed to expand our understanding of HLS language processing by investigating evidentiality-the linguistic marking of information source, which is grammatically expressed in Turkish, but not in English.MethodParticipants were 54 bilingual speakers of Turkish and English: 24 HLS (English onset: 0-5 yrs) and 30 emigrant Turkish speakers (ES) who grew up in Turkey before emigrating to Australia (English onset = 6-17 yrs). Participants read sentences with evidential-marked verb forms that either matched or mismatched to the information source context. Word-by-word reading times and end-of-sentence acceptability judgment speed and accuracy were measured.ResultsThe results showed that although the HLS' responses were slower and less accurate than the ES in both reading times and end-of-sentence acceptability judgments, they showed similarities in online processing patterns. Both groups were faster at reading the mismatching sentences compared to the matching sentences; however, this pattern emerged during the time course of reading first for the indirect condition for the ES, and only later for the direct condition and for the HLS for both evidential conditions. Only HLS read faster in the target region with the direct evidential that is shown to be acquired earlier in childhood, than they did for the indirect evidential which is mastered later. In contrast, the end-of-sentence judgment data showed that while the ES group responded faster to matching direct sentences than matching indirect, this effect was missing for the HLS. Nevertheless, there were similar patterns for accuracy across evidential conditions: both groups were more accurate with the direct evidential.DiscussionOverall, the use of the self-paced-reading paradigm allowed insights into HLS' evidentiality processing above and beyond their generally slower and less accurate processing compared to the reference group. This study provides further evidence for differences in the patterns observed using online vs. post interpretive measures in HLS, reinforcing the importance of combining these methodologies for further understanding of HLS competence and performance.
Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study
Authors: Frías Mario , Corona-Mata Diana , Moyano Jose M. , Camacho-Espejo Angela , López-López Pedro , Caballero-Gómez Javier , Ruiz-Cáceres Inmaculada , Casares-Jiménez Marı́a , Pérez-Valero Ignacio , Rivero-Juárez Antonio , Rivero Antonio 
Published: September 2023

Background &amp; objectiveNonalcoholic fatty liver disease (NAFLD) is highly prevalent in people living with HIV (PLWH) and the expression of some microRNAs could be useful as biomarkers for the diagnosis of NAFLD. The aim of this study was to identify patterns of differential expression of microRNAs in PLWH and assess their diagnostic value for NALFD.MethodsA discovery case-control study with PLWH was carried out. The expression of miRNAs was determined using HTG EdgeSeq technology. Cases were defined as patients with severe NAFLD and controls as patients without NAFLD, characterized using the controlled attenuation parameter (CAP). Cases and controls were matched 1:1 for age, sex, BMI, CD4+ lymphocyte count, active HCV infection, and ART regimen.ResultsSerum 2,083 simultaneous microRNA transcripts were analyzed using HTG technology and compared between cases and controls. Forty-five patients, 23 cases, and 22 controls were included in the study. In the analysis of the expression pattern of the 2,083 microRNAs, no differential expression patterns were found between both groups of patients included in the study.ConclusionAnalysis of the microRNA transcriptome profile of nonobese PLWH with severe NAFLD did not appear to differ from that of patients without NAFLD. Thus, microRNA might not serve as a proper biomarker for predicting severe NALFD in this population.
Lifestyle factors, serum parameters, metabolic comorbidities, and the risk of kidney stones: a Mendelian randomization study
Authors: Liu Minghui , Wu Jian , Gao Meng , Li Yongchao , Xia Weiping , Zhang Youjie , Chen Jinbo , Chen Zhiyong , Zhu Zewu , Chen Hequn 
Published: September 2023

Background and objectiveThe early identification of modifiable risk factors is important for preventing kidney stones but determining causal associations can be difficult with epidemiological data. We aimed to genetically assess the causality between modifiable factors (lifestyle factors, serum parameters, and metabolic comorbidities) and the risk of kidney stones. Additionally, we aimed to explore the causal impact of education on kidney stones and its potential mediating pathways.MethodsWe conducted a two-sample Mendelian randomization (MR) study to explore the causal association between 44 modifiable risk factors and kidney stones. The FinnGen dataset initially explored the causal relationship of risk factors with kidney stones and the UK Biobank dataset was used as the validation set. Then, a meta-analysis was conducted by combining discovery and validation datasets. We used two-step MR to assess potential mediators and their mediation proportions between education and kidney stones.ResultsThe combined results indicated that previous exposures may increase the risk of kidney stones, including sedentary behavior, urinary sodium, the urinary sodium/potassium ratio, the urinary sodium/creatinine ratio, serum calcium, 25-hydroxyvitamin D (25OHD), the estimated creatinine-based glomerular filtration rate (eGFRcrea), GFR estimated by serum cystatin C (eGFRcys), body mass index (BMI), waist circumference, type 2 diabetes mellitus (T2DM), fasting insulin, glycated hemoglobin, and hypertension. Coffee intake, plasma caffeine levels, educational attainment, and the urinary potassium/creatinine ratio may decrease the risk of kidney stones. Ranked by mediation proportion, the effect of education on the risk of kidney stones was mediated by five modifiable risk factors, including sedentary behavior (mediation proportion, 25.7%), smoking initiation (10.2%), BMI (8.2%), T2DM (5.8%), and waist circumference (3.2%).ConclusionThis study provides MR evidence supporting causal associations of many modifiable risk factors with kidney stones. Sedentary lifestyles, obesity, smoking, and T2DM are mediating factors in the causal relationship between educational attainment and kidney stones. Our results suggest more attention should be paid to these modifiable factors to prevent kidney stones.