bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of skin cancers in mycosis fungoides patients receiving PUVA therapy: A real‐life experience from a single tertiary center
Authors: Doğan Pelin Ertop , Akay Bengü Nisa , Vural Seçil , Arı Canan , Yılmaz Tuğçe Ertürk , Şanlı Hatice 
Published: March 2023

AbstractBackgroundMycosis fungoides (MF) is the most common cutaneous T‐cell lymphoma. Skin‐directed therapies, including phototherapy, are the first‐line treatment modalities. Psoralen plus ultraviolet A light photochemotherapy (PUVA) is quite effective in controlling the disease; however, long‐term adverse effects, particularly carcinogenesis, are the cons of this treatment.ObjectiveThere are various studies on the negative impact of PUVA on skin cancer in patients with autoimmune skin diseases. The data on the long‐term effects of phototherapy on MF patients are scarce.MethodsAll MF cases that received PUVA alone or combined with other treatments at a single tertiary center were analyzed. This study compared the development of non‐melanoma skin cancers, melanoma, and solid organ tumors in MF patients with at least 5‐year follow‐up data with age‐ and sex‐matched controls.ResultsA total of 104 patients were included in the study. Ninety‐two malignancies were detected in 16 (15.4%) patients, and six developed multiple malignancies. Skin cancers consisted of 56 basal cell carcinomas, 16 Bowen's disease, four squamous cell carcinomas, three melanomas, two basosquamous cell carcinomas, one Kaposi sarcoma, and one keratoacanthoma were found in nine (8.7%) patients. Eight patients developed three solid cancers and six lymphomas. The risk of developing skin cancer was associated with the total number of PUVA sessions (<250 vs ≥250 sessions; hazard ratio (HR) 4.44, 95% confidence interval (CI) 1.033–19.068; p = .045). 9 (13.2%) of 68 patients who had follow‐ups for at least 5 years developed skin cancer. Compared to an age‐ and sex‐matched cohort, the prevalence of new skin cancer was considerably greater (p = .009).ConclusionsPatients with MF are predisposed to develop secondary malignancies, and continual exposure to PUVA may potentiate this risk. Annual digital dermoscopic follow‐up in MF patients treated with UVA is advised for early diagnosis and treatment of secondary cutaneous malignancies.
CD193 (CCR3) expression by B cells correlates with reduced IgE production in paediatric schistosomiasis
Authors: Onkanga I. O. , Sang H. , Hamilton R. , Ondigo B. N. , Jaoko W. , Odiere M. R. , Ganley‐Leal L. 
Published: March 2023

AbstractWe demonstrate that CD193, the eotaxin receptor, is highly expressed on circulating B cells in paediatric schistosomiasis mansoni. CD193 plays a role in directing granulocytes into sites of allergic‐like inflammation in the mucosa, but little is known about its functional significance on human B cells. We sought to characterize CD193 expression and its relationship with S. mansoni infection. We found that CD193+ B cells increased with the intensity of schistosome infection. In addition, a significant negative association was observed between CD193 expression by B cells and IgE production. Decreased IgE levels are generally associated with susceptibility to re‐infection. B cell stimulation with eotaxin‐1 increased CD193 levels whereas IL‐4 led to a reduction. This was supported by plasma levels of eotaxin‐1 correlating with CD193 levels on B cells and other cells. In contrast, CD193 expression was induced on naive B cells with a combination of IL‐10 and schistosome antigens. Whereas T cells had a modest increase in CD193 expression, only B cell CD193 appeared functionally chemotactic to eotaxin‐1. Thus, CD193+ B cells, which co‐express CXCR5, may be enroute to sites with allergic‐like inflammation, such as gastrointestinal follicles, or even to Th2 granulomas, which develop around parasite eggs. Overall, our results suggest that schistosome infection may promote CD193 expression and suppress IgE via IL‐10 and other undefined mechanisms related to B cell trafficking. This study adds to our understanding of why young children may have poor immunity. Nonetheless, praziquantel treatment was shown to reduce percentages of circulating CD193+ B cells lending hope for future vaccine efforts.
Mobile advertisement campaigns for boosting in‐store visits: A design framework and case study
Authors: Keshanian Kimia , Ramasubbu Narayan , Dutta Kaushik 
Published: March 2023

Brick‐and‐mortar retailers seek higher foot traffic in their stores to improve their sales opportunities. In this quest, location‐based advertising on mobile devices has emerged as an important marketing tool for targeting potential customers. The design of such advertising campaigns is complex, and their effectiveness depends on the ability to collect and examine data that aids in targeting the right customers at the right time and place. We develop a campaign design framework that explicitly accounts for the costs of acquiring and utilizing targeting data and the heterogeneous effects of such data in affecting the performance outcomes of mobile advertising campaigns. We illustrate the application of our campaign design framework through a real‐world case study of a mobile advertising campaign undertaken by a large global retail firm. Our findings suggest that the optimal set of attributes to use for effectively targeting the potential customers of a brick‐and‐mortar retail store varies with the distance between the customers' current locations and that of the store. As a result, mobile campaign design approaches that utilize all or a naive subset of data attributes for targeted advertising yield lower levels of return on investments, relative to our proposed approach. Based on our results, we discuss implications for the design and deployment of mobile advertising campaigns and for further research on targeted advertising.
Sleep profile in a population of community‐dwelling nonagenarians: data from the Mugello study
Authors: Binazzi Barbara , Provini Federica , Pancani Silvia , Grippo Antonello , Vannetti Federica , Pasquini Guido , Frandi Roberta , Turcan Nona , Razzolini Lorenzo , Cecchi Francesca , Lova Raffaello Molino , Macchi Claudio 
Published: March 2023

BackgroundVery few studies have investigated sleep characteristics in the oldest‐old individuals (aged ≥85 years) and data collected often rely on self‐reported information. This study had three aims: (i) to objectively assess, using a wearable device, the sleep characteristics of a large community of oldest‐old subjects; (ii) to assess differences in sleep parameters between self‐reported ‘good sleepers’ and ‘bad sleepers’; (iii) to assess whether there was a relationship between sleep parameters and cognitive status in this community‐dwelling population.MethodsThere were 178 subjects (74.2% women, median age 92 years) included in the ‘Mugello study’, who wore an armband 24 h/day for at least two consecutive nights to estimate sleep parameters. The perceived sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), the cognitive status through the Mini‐Mental State Examination. Continuous variables were compared between men/women, and good/bad sleepers with the independent t‐test or Mann–Whitney U‐test, according to data distribution. Chi‐square test was used for categorical/dichotomous variables. An ordinal logistic regression model was used to study the possible association between sleep parameters and cognitive function.ResultsParticipants spent in bed nearly 9 h, with a total sleep time of 7 h, a sleep onset latency of 17 min, and a sleep efficiency of 83%. Sleep onset latency was significantly associated with different cognitive levels when age and education level were considered. No significant difference in sleep parameters estimated using the SenseWear armband were found between poor (n = 136, 76.4%) and good sleepers (n = 42, 23.6%), identified according to the PSQI.ConclusionsIn this study, actigraphic measurements revealed that subjects with a cognitive decline were more prone to increased sleep onset latency. Sleep quality assessed using the PSQI was not coherent with actigraphic measurements in this sample, supporting the need for objective measures when investigating sleep quality in the oldest‐old population.
Does government social spending matter? Exploring how income inequality is associated with charitable giving
Authors: Yang Yongzheng 
Published: March 2023

AbstractObjectiveGiven the detrimental consequences of income inequality and the importance of charitable giving in society, the relationship between income inequality and charitable giving has attracted much scholarly attention, but less is known about why and how income inequality is associated with charitable giving. This study intends to explore the role of government social spending in the relationship between income inequality and charitable giving.MethodBuilding upon previous theoretical arguments and empirical studies, I argue that income inequality is negatively related to government social spending, and government social spending is negatively related to charitable giving. Using the U.S. county‐level panel data (2011–2017), this study runs a series of fixed‐effects models.ResultsIt finds there is no significant relationship between income inequality and government social spending as well as between government social spending and charitable giving. However, income inequality has a robustly and significantly negative relationship with charitable giving.ConclusionGovernment social spending does not play a mediating role in the relationship between income inequality and charitable giving, but income inequality actually has a pernicious effect on individual philanthropy.
Airborne! UAV delivery of blood products and medical logistics for combat zones
Authors: Lammers Daniel T. , Williams James M. , Conner Jeffrey R. , Baird Emily , Rokayak Omar , McClellan John M. , Bingham Jason R. , Betzold Richard , Eckert Matthew J. 
Published: March 2023

AbstractBackgroundInnovative solutions to resupply critical medical logistics and blood products may be required in future near‐peer conflicts. Unmanned aerial vehicles (UAVs) are increasingly being used in austere environments and may be a viable platform for medical resupply and the transport of blood products.MethodsA literature review on PubMed and Google Scholar up to March of 2022 yielded a total of 27 articles that were included in this narrative review. The objectives of this article are to discuss the current limitations of prehospital blood transfusion in military settings, discuss the current uses of UAVs for medical logistics, and highlight the ongoing research surrounding UAVs for blood product delivery.DiscussionUAVs allow for the timely delivery of medical supplies in numerous settings and have been utilized for both military and civilian purposes. Investigations into the effects of aeromedical transportation on blood products have found minimal blood product degradation when appropriately thermoregulated and delivered in a manner that minimizes trauma. UAV delivery of blood products is now actively being explored by numerous entities around the globe. Current limitations surrounding the lack of high‐quality safety data, engineering constraints over carrying capacity, storage capability, and distance traveled, as well as air space regulations persist.ConclusionUAVs may offer a novel solution for the transport of medical supplies and blood products in a safe and timely manner for the forward‐deployed setting. Further research on optimal UAV design, optimal delivery techniques, and blood product safety following transport should be explored prior to implementation.
On the Fractional Diffusion Equation Associated With Exponential Source and Operator With Exponential Kernel
Authors: Nguyen Anh Tuan , Nguyen Van Tien , Baleanu Dumitru , Nguyen Van Thinh 
Published: March 2023

AbstractIn this paper, we investigate the well-posedness of mild solutions of the time-fractional diffusion equation with an exponential source function and the Caputo-Fabrizio derivative of a fractional order α∈(0,1). Some linear estimates of the solution kernels on Hilbert scale spaces are constructed using a spectrum of the Dirichlet Laplacian. Based on the Banach fixed point theorem, the global existence and uniqueness of the small-data mild solution are approved. This work is considered the first study on the time-fractional diffusion equation with a nonlinear function for all common dimensions of 1, 2, and 3.
Period-1 Motions to Twin Spiral Homoclinic Orbits in the Rössler System
Authors: Xing Siyuan , Luo Albert C. J. 
Published: March 2023

Abstract
In this paper, period-1 motions to twin spiral homoclinic orbits in the Rössler system are presented. The period-1 motions varying with a system parameter are predicted semi-analytically through an implicit mapping method, and the corresponding stability and bifurcations of the period-1 motions are determined through eigenvalue analysis. The approximate homoclinic orbits are obtained, which can be detected through the periodic motions with the positive and negative infinite large eigenvalues. The two limit ends of the bifurcation diagram of the period-1 motion are at twin spiral homoclinic orbits. For comparison, numerical and analytical results of stable period-1 motion are presented. The approximate spiral homoclinic orbits are demonstrated for a better understanding of complex dynamics of homoclinic orbits. Herein, only initial results on periodic motions to homoclinic orbits are presented for the Rössler system. In fact, the Rössler system has rich complex dynamics existing in other high-dimensional nonlinear systems. Thus, the further studies of bifurcation trees of periodic motions to infinite homoclinic orbits will be completed in sequel.
Efficient Hybrid Symbolic-Numeric Computational Method for Piecewise Linear Systems With Coulomb Friction
Authors: Shahhosseini Amir , Tien Meng-Hsuan , D'Souza Kiran 
Published: March 2023

Abstract
A wide range of mechanical systems have gaps, cracks, intermittent contact or other geometrical discontinuities while simultaneously experiencing Coulomb friction. A piecewise linear model with discontinuous force elements is discussed in this paper that has the capability to accurately emulate the behavior of such mechanical assemblies. The mathematical formulation of the model is standardized via a universal differential inclusion and its behavior, in different scenarios, is studied. In addition to the compatibility of the proposed model with numerous industrial systems, the model also bears significant scientific value since it can demonstrate a wide spectrum of motions, ranging from periodic to chaotic. Furthermore, it is demonstrated that this class of models can generate a rare type of motion, called weakly chaotic motion. After their detailed introduction and analysis, an efficient hybrid symbolic-numeric computational method is introduced that can accurately obtain the arbitrary response of this class of nonlinear models. The proposed method is capable of treating high dimensional systems and its proposition omits the need for utilizing model reduction techniques for a wide range of problems. In contrast to the existing literature focused on improving the computational performance when analyzing these systems when there is a periodic response, this method is able to capture transient and nonstationary dynamics and is not restricted to only steady-state periodic responses.
Tuberculous flexor tenosynovitis of wrist and hand
Authors: Giri Sanjay Kumar , Suba Santanu , Bandyopadhyay Ahana , R Pavithra 
Published: March 2023

A woman in her 40s presented with a swelling over her left distal forearm and hand since 7 months, progressively increasing in size. She had history of difficulty in moving her wrist and fingers with no associated pain. She had no immune or chronic conditions except for hypothyroidism for which she was on regular medication. On examination, there was an 8×7 cm swelling on the radial side of the volar surface of her left distal forearm extending till the thenar eminence. MRI of the left upper limb was suggestive of a soft tissue swelling arising from the flexor tendon.The patient was planned for surgical excision of the swelling. Intraoperatively, there was a mass arising from the flexor tendons of flexor digitorum superficialis, flexor digitorum profundus (FDP) and flexor pollicis longus (FPL), extending distally up to the mid palm region. On incising the flexor tendon sheath, it was observed that multiple yellowish rice like granules extended across the tendons. The lesion was excised completely and sent for histopathology examination. The lax FDP of little and ring fingers were plicated following proper tension adjustment and defect in FPL was primarily repaired. Postoperatively, the patient recovered well with no local wound complications. The biopsy report was suggestive of tuberculosis. The patient completed a course of antituberculosis treatment in 6 months.
Application of multilevel linear spline models for analysis of growth trajectories in a cohort with repeat antenatal and postnatal measures of growth: a prospective cohort study
Authors: O'Keeffe Linda M , Yelverton Cara A , Bartels Helena C , O'Neill Kate N , McDonnell Ciara , McAuliffe Fionnuala M 
Published: March 2023

ObjectivesTo model trajectories of antenatal and postnatal growth using linear spline multilevel models.DesignProspective cohort study.SettingMaternity hospital in Dublin, Ireland.Participants720–759 mother–child pairs from the ROLO study (initially a randomised control trial of a low glycaemic index diet in pregnancy to prevent recurrence of macrosomia [birth weight >4 kg]).Primary outcomesTrajectories of growth from 20 weeks gestation (abdominal circumference [AC], head circumference [HC] and weight) or birth (length/height) to 5 years.ResultsOver 50% of women had third-level education and 90% were of white ethnicity. Women were a mean (SD) age of 32 years (4.2) at recruitment. The best fitting model for AC, HC and weight included a model with 5 linear spline periods. The best fitting models for length/height included a model with 3 linear spline periods from birth to 6 months, 6 months to 2 years and 2 years to 5 years. Comparison of observed and predicted values for each model demonstrated good model fit. For all growth measures, growth rates were generally fastest in pregnancy or immediately post partum (for length/height), with rates of growth slowing after birth and becoming slower still as infancy and childhood progressed.ConclusionWe demonstrate the application of multilevel linear spline models for examining growth trajectories when both antenatal and postnatal measures of growth are available. The approach may be useful for cohort studies or randomised control trials with repeat prospective assessments of growth.
Subanaesthetic single-dose ketamine as an adjunct to opioid analgesics for acute pain management in the emergency department: a systematic review and meta-analysis
Authors: Fjendbo Galili Stine , Nikolajsen Lone , Papadomanolakis-Pakis Nicholas 
Published: March 2023

ObjectiveTo evaluate the effectiveness of a subanaesthetic single-dose ketamine (SDK) as an adjunct to opioids for acute pain in emergency department (ED) settings.DesignSystematic review and meta-analysis.MethodsA systematic search was performed in MEDLINE, Embase, Scopus and Web of Science through March 2022. Randomised controlled trials (RCTs) that investigated SDK as an adjunct to opioids in adult patients for any painful condition in ED settings were selected. Two reviewers screened studies, extracted data and assessed study quality. Data were pooled using random-effects models. The primary outcome was mean pain intensity score measured at baseline, >0–15 min, >15–30 min, >30–45 min, 60 min, 90 min and 120 min. Secondary outcomes included need for rescue analgesia, adverse events and patient satisfaction. Results were reported as mean differences (MDs) and risk ratios. Statistical heterogeneity was calculated using theI2statistic.ResultsEight RCTs were included (n=903). Studies were judged to be at moderate to high risk of bias. Mean pain intensity scores were significantly lower 60 min after study drug administration favouring adjuvant SDK (MD −0.76; 95% CI −1.19 to −0.33), compared with opioids alone. There was no evidence of differences in mean pain intensity scores at any other time point. Patients who received adjuvant SDK were less likely to require rescue analgesia, no more likely to experience serious side effects and had higher satisfaction scores, compared with opioids alone.ConclusionsAvailable evidence suggests adjuvant SDK can have an effect on lowering pain intensity scores. Although reduction of pain scores was not clinically significant, the combination of reduced pain intensity and reduced opioid requirements suggest the results could be clinically important and support the potential utility of SDK as an adjunct to opioids to treat acute pain in adult ED patients. However, current evidence is limited and higher quality RCTs are needed.PROSPERO registration numberCRD42021276708.
Cohort profile – the Renal cell cancer: Lifestyle, prognosis and quality of life (ReLife) study in the Netherlands
Authors: Maurits Jake S F , Sedelaar J P Michiel , Aben Katja K H , Kampman Ellen ,   The ReLife study group, Kiemeney Lambertus A L M , Vrieling Alina 
Published: March 2023

PurposeThe Renal cell cancer: Lifestyle, prognosis and quality of life (ReLife) study is set up to obtain insight into the association of patient and tumour characteristics, lifestyle habits and circulating biomarkers with body composition features in patients with localised renal cell cancer (RCC). Further, it aims to assess the association of body composition features, lifestyle habits and circulating biomarkers with clinical outcomes, including health-related quality of life.ParticipantsThe ReLife study is a multicentre prospective cohort study involving 368 patients with newly diagnosed stages I–III RCC recruited from January 2018 to June 2021 from 18 hospitals in the Netherlands. At 3 months, 1 year and 2 years after treatment, participants fill out a general questionnaire and questionnaires about their lifestyle habits (eg, diet, physical activity, smoking and alcohol consumption), medical history and health-related quality of life. At all three time points, patients wear an accelerometer and have blood samples taken. CT scans for body composition analysis are being collected. Permission is asked for collection of tumour samples. Information about disease characteristics, treatment of the primary tumour and clinical outcomes is being collected from medical records by the Netherlands Cancer Registry.Findings to dateA total of 836 invited patients were eligible and 368 patients were willing to participate and were included (response rate 44%). The mean age of patients was 62.5±9.0 years and 70% was male. The majority had stage I (65%) disease and were treated with radical nephrectomy (57%). Data collection at 3 months and 1 years after treatment have been finalised.Future plansData collection at 2 years after treatment is expected to be finalised in June 2023 and longitudinal clinical data will continue to be collected. Results of studies based on this cohort are important to develop personalised evidence-based lifestyle advice for patients with localised RCC to enable them to get more control over their disease course.