bluuebunny/crossref_metadata_2025_split huggingface dataset:
A predatory mite that suppresses Diaphorina citri populations on plants with pollen and oviposition sites
Authors: Kalile Milena O. , Cardoso André C. , Pallini Angelo , Fonseca Morgana M. , Ferreira‐Junior Tarciso A. , Janssen Arne 
Published: May 2023

AbstractThe Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Psyllidae), is the major citrus pest worldwide because it can transmit the bacteria associated with citrus greening disease (huanglongbing, HLB). The most common management strategy of this pest is chemical control, but this often results in pest resistance and threatens the sustainability of the citrus culture. There is therefore need for sustainable control strategies such as biological control. Previous experiments showed that the predatory mite Amblyseius herbicolus Chant (Acari: Phytoseiidae) is able to develop and reproduce on D. citri eggs. Here, we studied the population dynamics of this pest on plants with and without A. herbicolus on isolated orange jasmine plants, Murraya paniculata (L.) Jack (Rutaceae), an important host plant of the pest. Predatory mites were released 1 week before the release of D. citri and were provided with twines with pollen as oviposition sites and food source, respectively, to maintain populations of A. herbicolus in the absence of the pest. Densities of adults and nymphs of D. citri on plants with predators were about 85% lower than on plants without predators, showing that A. herbicolus is a potential biocontrol agent of D. citri. However, the stage structure of the D. citri populations at the end of the experiment did not differ significantly between control plants and plants with predators. This led us to investigate whether the predator attacked other stages besides eggs. Indeed, predators were able to feed and reproduce on first and second instar nymphs of D. citri, but not on instars 3–5. Concluding, the release of A. herbicolus with alternative food and oviposition sites can reduce infestations of D. citri. We suggest that field experiments should be done in areas where HLB occurs to test whether releases of this predator limit the spread of this devastating disease.
Mesenchymal stromal cells and CAR‐T cells in regenerative medicine: The homing procedure and their effective parameters
Authors: Kolahi Azar Hanieh , Imanpour Aylar , Rezaee Hanieh , Ezzatifar Fatemeh , Zarei‐Behjani Zeinab , Rostami Mohammadreza , Azami Mahmoud , Behestizadeh Nima , Rezaei Nima 
Published: May 2023

AbstractMesenchymal stromal cells (MSCs) and chimeric antigen receptor (CAR)‐T cells are two core elements in cell therapy procedures. MSCs have significant immunomodulatory effects that alleviate inflammation in the tissue regeneration process, while administration of specific chemokines and adhesive molecules would primarily facilitate CAR‐T cell trafficking into solid tumors. Multiple parameters affect cell homing, including the recipient's age, the number of cell passages, proper cell culture, and the delivery method. In addition, several chemokines are involved in the tumor microenvironment, affecting the homing procedure. This review discusses parameters that improve the efficiency of cell homing and significant cell therapy challenges. Emerging comprehensive mechanistic strategies such as non‐systemic and systemic homing that revealed a significant role in cell therapy remodeling were also reviewed. Finally, the primary implications for the development of combination therapies that incorporate both MSCs and CAR‐T cells for cancer treatment were discussed.
Success rate of permanent teeth pulpotomy using bioactive materials: A systematic review and meta‐analysis of randomized clinical trials
Authors: Silva Emmanuel J. N. L. , Pinto Karem P. , Belladonna Felipe G. , Ferreira Claudio M. A. , Versiani Marco A. , De‐Deus Gustavo 
Published: May 2023

AbstractBackgroundThe results of vital pulp treatments in permanent teeth have been encouraging. Currently, pulpotomy treatment for permanent teeth primarily utilizes mineral trioxide aggregate (MTA) as the dressing material, followed by calcium hydroxide. While other calcium‐silicate‐based cements have been suggested for pulpotomy, there is a limited number of studies evaluating their long‐term effectiveness.ObjectivesThe objective of this systematic review and meta‐analysis was to evaluate the success rate of pulpotomies performed on permanent teeth, comparing the use of ProRoot MTA with that of calcium hydroxide and other bioceramic materials.MethodsA comprehensive search was conducted in several electronic databases, including PubMed, Cochrane Library, Scopus, Web of Science, Embase and Science Direct until December 2022. The search was guided by PICOS criteria, including only randomized clinical trials (RCTs) that evaluated the success rate of pulpotomy treatments in permanent teeth using ProRoot MTA in comparison to calcium hydroxide and other bioceramic materials. The quality of the included studies was assessed using the RoB‐2 tool to evaluate the risk of bias, and relevant data were extracted and analysed in RevMan software 5.3 using fixed‐effect models. The GRADE tool was used to determine the overall quality of evidence.ResultsThe initial search retrieved 1072 studies and, after eliminating duplicates, 677 studies were screened and 28 studies were considered for eligibility. In the final selection process, 16 studies were included in the systematic review, with 10 being determined as having a high risk of bias. Pulpotomy showed an overall mean success rate of 92% after 1 year. The meta‐analysis indicated a significantly higher success rate for pulpotomies utilizing MTA in comparison with calcium hydroxide, while no significant difference was seen between MTA and calcium‐enriched mixture (CEM) or Biodentine. The GRADE assessment revealed an overall low level of evidence for the included studies.DiscussionMost randomized controlled trials exhibited a significant absence of control over confounding factors.ConclusionsThis systematic review and meta‐analysis demonstrate that pulpotomy is a highly effective treatment for managing permanent teeth. The results indicate that the success rate of pulpotomy using ProRoot MTA is significantly higher than when using calcium hydroxide. However, the certainty of evidence supporting these findings is low, and there is a need for well‐designed RCTs to assess the long‐term outcomes of pulpotomy using newer bioceramic materials.RegistrationThis systematic review was registered in the PROSPERO database (registration number CRD42023393970).
Risk factors for malignancy and serious infection in patients with inflammatory bowel disease: a retrospective analysis
Authors: Tassone Daniel , Basnayake Chamara , Wright Emily , Lust Mark , Kamm Michael A. , Niewiadomski Ola , Schulberg Julien , Flanagan Emma , Samyue Tamie , Fry Stephanie , Malcolm Ruth , Stanley Annalise , Thompson Alexander J. , Connell William R. , Ding Nik S. 
Published: May 2023

AbstractBackgroundPatients with inflammatory bowel disease (IBD) are at increased risk of malignancy and infection compared to the general population.AimsWe aim to identify risk factors for malignancy or serious infection in our IBD cohort.MethodsPatients with IBD from a single tertiary referral centre were included. Demographic and clinical details, including immunosuppressant exposure, were collected and medical records retrospectively screened for adverse events, including malignancy or infection requiring hospitalisation. Logistic regression was used to evaluate risk factors for adverse events.ResultsFive hundred and forty‐nine patients with IBD (340 Crohn disease (CD) and 209 ulcerative colitis (UC)) were studied. Forty‐eight malignancies, including 39 (81.3%) non‐melanoma skin cancers, 3 (6.3%) haematologic malignancies and 6 (15.4%) solid‐organ malignancies, were identified, and 92 cases of serious infection were detected. IBD duration (odds ratio (OR) = 1.08; 95% confidence interval (CI) = 1.03–1.13) and ileocolonic CD (OR = 4.96; 95% CI = 1.13–21.71) were associated with increased odds of overall cancer. Compared with patients not previously exposed to the given class of immunosuppression assessed, the development of overall malignancy was not higher with thiopurine exposure (OR = 1.00; 95% CI = 0.50–2.24) or anti‐tumour necrosis factor‐alpha (TNF‐α) exposure (OR = 0.78; 95% CI = 0.37–1.64). Similarly, compared with patients not exposed, infection risk was not affected by thiopurine (OR = 0.74; 95% CI = 0.46–1.20) or anti‐TNF exposure (OR = 0.60; 95% CI = 0.38–0.95).ConclusionsFactors including ileocolonic CD and increasing IBD duration were associated with higher malignancy risk in this cohort. Compared with non‐exposure, patients exposed to thiopurines were not at increased risk of malignancy or serious infection. Similarly, patients exposed to anti‐TNF treatment did not experience increased rates of malignancy or serious infection compared to patients not exposed to this treatment.
How therapeutic advances have transformed the medical landscape: a primer for clinicians
Authors: Ghinea Narcyz , Lipworth Wendy , Kerridge Ian , Zalcberg John R. 
Published: May 2023

AbstractNovel medicines are entering the market rapidly and are increasingly being used alone or in combination to treat illnesses of every sort. While transforming the lives of many patients, these new therapies have also forced us to reconsider the way we evaluate, use and fund medicines. This article offers a primer to help practitioners understand how the therapeutic landscape is changing and how this might impact the evidence generation, access to interventions, patient experience and quality of care.
Impact on aggregate/matrix bonding when a refractory contains zinc aluminate instead of spinel and magnesia‐chrome
Authors: Mandal Somnath , Hemrick James G. , Mahapatra Manoj K. 
Published: May 2023

AbstractThe high hot strength of MgO–Cr2O3 refractory is often ascribed to its intimate aggregate/matrix bonding. For a fundamental comparison with it, ∼2 mm aggregates of MgO and Al2O3 were separately embedded in ZnAl2O4 and MgAl2O4 matrices, sintered at 1600°C, and examined. It was found that similarity of thermal expansion coefficient (TEC) between the aggregate and the matrix is critical to achieve good bonding and this is more important than the extent of interdiffusion. The TEC mismatch of ≥5.7 × 10−6 K−1 caused significant undesirable debonding in MgO aggregate/MgAl2O4 matrix sample and MgO/ZnAl2O4 despite >736 μm Zn2+ diffusion depth in the latter. Direct bonding, as inferred from a thicker interfacial reaction layer and a greater shift of the aggregate/matrix interface before and after firing, was better in MgAl2O4/ZnAl2O4 combination, followed by tabular Al2O3/ZnAl2O4 and Al2O3/MgAl2O4. Powder X‐ray diffraction indicated that the volatilization of ZnAl2O4 at 1600°C in air was negligible compared to MgO–Cr2O3.
Revising the computer programming attitude scale in the context of attitude ambivalence
Authors: Yusuf Abdullahi , Noor Norah Md 
Published: May 2023

AbstractBackgroundSeveral attitude scales have been developed to measure students' attitudes toward computer programming, including the prominent one developed by Cetin and Ozden. The development of these scales stemmed from the elusive nature of attitude and the lack of specific constructs to measure attitude. These instruments measure students' attitudes based on one‐dimensional perspective, thus, making it difficult to interpret the meaning of some attitude evaluations such as the meaning of neutral points in a 10‐point scale (for example).ObjectivesThe computer programming attitude scale was modified to measure ambivalence. The study also investigate attitude differences across demographic variables and used these variables to predict ambivalence.MethodsThe study was conducted in two phases. In the first phase, the instrument was validated using exploratory factor analysis and confirmatory factor analysis. In the second phase, the revised scale was administered to another 547 students in four research universities for empirical investigation.ResultsResults show that the instrument is valid and suitable for measuring students' programming attitudes. Participants' attitudes skewed toward the negative attitude dimension. Lastly, we found that both attitude and ambivalence are factors of programming experience.ConclusionsWe discussed the findings, recommend the instrument to programming tutors, and strongly emphasise the evaluation of students' ambivalent attitudes.
Position in the laying order has sex-specific consequences for reproductive success in adult black-headed gulls
Authors: Bebbington Kat , Groothuis Ton G. G. 
Published: May 2023

Abstract
Mothers who produce multiple offspring within one reproductive attempt often allocate resources differentially; some maternally derived substances are preferentially allocated to last-produced offspring and others to first-produced offspring. The combined effect of these different allocation regimes on the overall fitness of offspring produced early or late in the sequence is not well understood, partly because production order is often coupled with birth order, making it difficult-to-separate effects of pre-natal maternal allocation from those of post-natal social environments. In addition, very little is known about the influence of laying order on fitness in later life. In this study, we used a semi-natural captive colony of black-headed gulls to test whether an offspring's position in the laying order affected its early-life survival and later-life reproductive success, independent of its hatching order. Later-laid eggs were less likely to hatch, but among those that did, survival to adulthood was greater than that of first-laid eggs. In adulthood, the laying order of females did not affect their likelihood of breeding in the colony, but male offspring hatched from last-laid eggs were significantly less likely to gain a breeding position than earlier-laid males. In contrast, later-laid female parents hatched lower proportions of their clutches than first-laid females, but hatching success was unrelated to the laying order of male parents. Our results indicate that gull mothers induce complex and sex-specific effects on both the early survival of their offspring and on long-term reproductive success through laying order effects among eggs of the same breeding attempt.
Abstract
In spite of suffering lower hatching success, later-laid black-headed gull offspring do not experience a reduction in survival to adulthood. While males and females from last-laid eggs suffered reduced reproductive success, this affected different components of reproduction: males hatched from last-laid eggs were less likely to become breeders, whereas females from last-laid eggs had lower offspring hatching success in their first breeding attempt..
Significant increased bacterial contamination with endoscope overnight and weekend storage times
Authors: Guadagnin Simone Vieira Toledo , Costa Dayane de Melo , Primo Mariusa Gomes Borges , Silva Adriana Azevedo , Leão‐Vasconcelos Lara Stefânia Netto de Oliveira , Vickery Karen , Tipple Anaclara Ferreira Veiga 
Published: May 2023

AbstractBackground and AimForced‐air drying (FAD) cabinets are recommended for storage of reprocessed endoscopes, but financial constraints prevent their universal application. The study aimed to determine bacterial contamination in flexible gastroscopes (FG) channels after storage, in a cabinet with filtered air and UV lights, but without FAD.MethodsEight FG in clinical use in an endoscopy service of a large Brazilian hospital were sampled: immediately “Time zero” (N = 50), 12 h “Time 1” (N = 25), and 60 h “Time 2” (N = 25) after reprocessing. Following a flush‐brush‐flush of channels, 40‐mL sterile water and 3 cm of the brush were collected. Each sample was divided, filtered onto two 0.22‐μm membranes, and incubated in media without or with disinfectant neutralizer. Automated method was used for identification and antibiotic resistance test of isolated bacteria.ResultsBacterial contamination in times “1” and “2” was 5.9 and 16.1 times greater than that of “Time zero,” respectively. Number of positive cultures in media with and without neutralizer was similar at times “1” and “2,” while media with neutralizer produced more positive cultures at “Time zero.” Most bacteria isolated at “Time 2” were Gram‐negative rods (52.3%) and showed resistance to one or more antibiotics (65%).ConclusionBacterial contamination was detected on reprocessed FG stored in non‐FAD cabinets overnight (12 h) and increased with longer storage time (60 h). The contamination source is likely to be bacteria in biofilm which multiply in the absence of FAD. Evidence‐based criteria should be available for storage time according to the cabinet available.
Relative growth and morphological sexual maturity of the caridean prawn Macrobrachium villosimanus (Tiwari, 1949) (Decapoda: Palaemonidae)
Authors: Ahamed Ferdous , Ahmed Zoarder Faruque , Ohtomi Jun 
Published: May 2023

AbstractReproductive success for crustaceans depends on the transition from juvenile to adult, which can be estimated by analysing relative growth. To this end, the present study focused on the relative growth of appendix masculina length (AML), hatchery chamber width (HCW), body length (BL) and body weight (BW) in relation to carapace length (CL) of Macrobrachium villosimanus to estimate the morphological sexual maturity using the least squares method. Data for each relationship were repeatedly partitioned into two size‐delimited subsets (juvenile and adult stages), considering a CL value as a hypothesized transition point. Analysis of the residuals sum of squares indicated two separate linear regressions fit the data better than a single linear regression. The study results indicated a discontinuity in allometry at 17.9 mm CL for CL versus AML, and at 15.6 mm CL for CL versus HCW relationships. These observed transition points could be associated with morphological sexual maturity of M. villosimanus. The BL and BW growth rate in relation to CL significantly decreased in males, but increased in females after reaching the morphological sexual maturity, demonstrating the existence of dimorphic growth. The increased growth rate after reaching sexual maturity in females probably corresponds to more space for the eggs and subsequent increased fertility. Accordingly, the present study indicated the secondary sexual characters (e.g. AML and HCW) play roles in attaining the morphological sexual maturity necessary for reproductive success and for ensuring the life cycle of this species.
Education on neuromuscular electrodiagnosis and neurological symptomatology
Authors: Sonoo Masahiro 
Published: May 2023

AbstractNeurological symptomatology is a crucial component of neurological expertise. The committee for fostering board‐certified neurologists in the Japanese Society of Neurology (JSN) has hosted an educational activity for residents before the board examination, “The seminar for fostering board‐certified neurologists” since 2004. In particular, the autumn seminar has been characterized by small group hands‐on of neurological examinations and the evaluations of higher brain function. Besides this, hands‐on seminar of neurological examinations by regional branches has been promoted by the JSN. In the Kanto Ko‐shin‐etsu branch, “The first hands‐on seminar of neurological examinations” started in 2023 after a 3‐year‐suspension due to COVID‐19. The most important educational activities in neuromuscular electrodiagnosis (EDx) is the “Neuromuscular diagnostics seminar” hosted since 2004 by the Japanese Society of Clinical Neurophysiology (JSCN). The majority of tutors and participants are neurologists. This seminar is also characterized by small‐group, hands‐on workshops. We have also run the overseas seminar, “Tokyo Super EMG hands‐on,” since 2013. These have undoubtedly contributed to enhancing the level of neuromuscular electrodiagnosis not only in Japan but also in other Asian countries. I have conducted studies on neurological symptomatology and neuromuscular electrodiagnosis, which are directly linked to enhancing clinical practice of neurologists through educational activities such as review articles or lectures. Due to the fact that symptomatology is crucial in neurological expertise, neurology is a basic specialty around the world except in Japan. In 2018, the JSN decided to aim to make neurology a basic specialty and continues to make efforts to attain this goal.
Evidence of scientific research on organic plant breeding: A bibliometric study
Authors: Mitrović Bojan , Zorić Miroslav , Terzić Sreten , Živanov Dalibor , Čanak Petar , Milošević Branko , Karagić Đura 
Published: May 2023

AbstractUse of varieties bred under organic conditions is essential in order to minimize the yield gap between organic and conventional agriculture. The aim of this study was to analyse research publications related to the topic ‘organic plant breeding’ from the Web of Science database using bibliometric science mapping and visualization tools. The number of analysed documents in the bibliographic dataset was 204 from the 53 sources. The overall trend in the organic plant breeding literature showed that the number of publications increased during the observed time‐span. We found that in total, 65 countries and 337 institutions are active in the field of organic plant breeding with a high degree of international collaboration. The top five countries according to the number of publications were the United States, Italy, Germany, France, and Canada, while the most active institutions were Wageningen University, Iowa State University, University of Alberta, University of Copenhagen, and University of Hohenheim. All keywords from the organic plant breeding research in the agronomy category were separated into seven clusters for different research topics. Although there is evident progress viewed through the increased trend in the number of publications, organic plant breeding needs further expansion and development. This is especially through the implementation of novel plant breeding techniques and methods aiming to improve traits that are highly specific to organic conditions.
The role of height and weight growth in spontaneous resolution of vesicoureteral reflux
Authors: Torun Bayram Meral , Kavukçu Salih , Koker Alper , Türkmen Mehmet , Soylu Alper 
Published: May 2023

AbstractBackgroundThe aim of this study was to investigate the role of height and weight growth in the resolution of primary vesicoureteral reflux (VUR).MethodsWe retrospectively evaluated the data of 74 males and 135 females who were diagnosed with primary VUR. According to the vesicoureteral reflux resolution, patients were divided into two groups. Patients with complete or partial resolution of VUR were included in Group 1 and patients with no resolution of VUR were included in Group 2. Patients were evaluated for weight Z‐score, height Z‐score and body mass index at the diagnosis and in the follow‐up. In addition, age, sex, grade of reflux and laterality were recorded.ResultsThere were no significant differences between the two groups, according to height Z‐score, weight Z‐score and body mass index at the diagnosis, in the follow‐up and also annual changes of these parameters. In addition, the same parameters did not significantly differ in Groups 1 and 2, between the initial and final evaluations. However, when we evaluate the patients older than 12 months old, weight Z‐scores were significantly higher at the final evaluation than at the diagnosis, in Group 1. This significant difference was not detected in Group 2 at the same age.ConclusionsAlthough we could not detect the hectic pace of height growth as being important in the prediction of long‐term outcomes of VUR, weight growth should be considered to predict the resolution of VUR.