bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Social Media for Identifying Adverse Drug Events Data in Pharmacovigilance: Protocol for a Scoping Review
Authors: Golder Su , O'Connor Karen , Wang Yunwen , Gonzalez Hernandez Graciela 
Published: May 2023

Background
Adverse drug events (ADEs) are a considerable public health burden resulting in disability, hospitalization, and death. Even those ADEs deemed nonserious can severely impact a patient’s quality of life and adherence to intervention. Monitoring medication safety, however, is challenging. Social media may be a useful adjunct for obtaining real-world data on ADEs. While many studies have been undertaken to detect adverse events on social media, a consensus has not yet been reached as to the value of social media in pharmacovigilance or its role in pharmacovigilance in relation to more traditional data sources.

Objective
The aim of the study is to evaluate and characterize the use of social media in ADE detection and pharmacovigilance as compared to other data sources.

Methods
A scoping review will be undertaken. We will search 11 bibliographical databases as well as Google Scholar, hand-searching, and forward and backward citation searching. Records will be screened in Covidence by 2 independent reviewers at both title and abstract stage as well as full text. Studies will be included if they used any type of social media (such as Twitter or patient forums) to detect any type of adverse event associated with any type of medication and then compared the results from social media to any other data source (such as spontaneous reporting systems or clinical literature). Data will be extracted using a data extraction sheet piloted by the authors. Important data on the types of methods used (such as machine learning), any limitations of the methods used, types of adverse events and drugs searched for and included, availability of data and code, details of the comparison data source, and the results and conclusions will be extracted.

Results
We will present descriptive summary statistics as well as identify any patterns in the types and timing of ADEs detected, including but not limited to the similarities and differences in what is reported, gaps in the evidence, and the methods used to extract ADEs from social media data. We will also summarize how the data from social media compares to conventional data sources. The literature will be organized by the data source for comparison. Where possible, we will analyze the impact of the types of adverse events, the social media platform used, and the methods used.

Conclusions
This scoping review will provide a valuable summary of a large body of research and important information for pharmacovigilance as well as suggest future directions of further research in this area. Through the comparisons with other data sources, we will be able to conclude the added value of social media in monitoring adverse events of medications, in terms of type of adverse events and timing.

International Registered Report Identifier (IRRID)
PRR1-10.2196/47068
Silicon dioxide nanoparticles inhibit the effects of cold exposure on metabolism and inflammatory responses in brown adipocytes
Authors: Zhang Yongqiang , Zhang Li , Wu Shuai , Zhang Guanyu , Wei Xiaodie , Li Xi , Yang Danfeng 
Published: May 2023

Abstract

Objective
Nanoparticles (NPs) in haze are potentially hazardous to health, which is more severe in the winter. Brown adipose tissue (BAT) plays important roles in obesity, insulin resistance, and diabetes. Though the toxicology of NPs has been intensively studied, few studies have been reported on the antagonistic effects between Silicon dioxide(SiO2) NPs and cold exposure in brown adipocytes.

Materials and methods
We evaluated changes by quantitative real-time reverse-transcriptase polymerase chain reaction (qRT-PCR) on metabolism genes, plasticity genes and the inflammatory responses genes in brown adipocytes in vitro.

Results
The expression of adipogenic genes PRDM16, Dio2, PGC-1α and UCP1 was upregulated upon cold exposure (P < 0.05), but downregulated by SiO2 NPs (P < 0.05). The results demonstrated that there was antagonistic effect between SiO2 NPs and cold exposure on the plasticity genes and metabolism genes in brown adipocytes, where the main effects of SiO2 NPs or cold exposure on the plasticity genes and metabolism genes were significant (P < 0.05). Moreover, the levels of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α were upregulated by SiO2 NPs or cold exposure (P < 0.05). The factorial analysis indicated that there was also antagonistic effect between SiO2 NPs and cold exposure on the toxic effects in brown adipocytes, in which the main effects of cold exposure and/or SiO2 NPs on the toxic effects were significant (P < 0.05).

Conclusion
SiO2 NPs inhibit the effect of cold exposure on metabolic genes and inflammatory responses genes in brown adipocytes.
Advances in the application of cryotherapy to the treatment of breast cancer
Authors: Ma Tianfei , Fan Yueren , Zhao Yihang , Liu Bin 
Published: May 2023

Abstract
Cryotherapy is a minimally invasive treatment. With increasing rate of breast cancer detection, ablation therapy has become an alternative approach for the treatment of this pathology due to its advantages of minimally invasive, fewer complications, good efficacy, and repeatability. Preclinical and clinical studies of cryotherapy for breast cancer published through December 2022 were identified through a literature search using PubMed, ClinicalTrials.gov, and CNKI. This article reviews the progress of cryoablation in the treatment of breast cancer.
Profiling Mycoplasma hyopneumoniae Infection in Commercial Pig Farms Using Serology and Lung Lesions Assessment
Authors: Angjelovski Branko , Orenga Clara Marin , Janevski Aleksandar , Dodovski Aleksandar , Prodanovic Radisa , Bojkovski Jovan 
Published: May 2023

Abstract

Mycoplasma hyopneumoniae (Mhyo) is primary pathogen involved in porcine respiratory diseases complex (PRDC). The objective of this study was to evaluate Mycoplasma hyopneumoniae (Mhyo) infection in five commercial pig farms by using serology and lung lesion scoring at slaughter. Five Macedonian pig herds with a history of respiratory diseases were included in the study. Blood samples were taken from pigs at 6, 10, 14, 18, and 22 weeks of age. Ten animals per age group from each farm were sampled and tested for antibodies to Mhyo. At abattoir, 50 lungs per farm were scored for lesions associated with enzootic pneumonia (EP). All farms were seropositive to Mhyo. Higher seroprevalence to Mhyo was observed in grower and finisher pigs, while significant difference (p<0.001) was detected among farms in 10-, 14-, and 22-week-old pigs. Enzootic pneumonia-like lesions were detected in 91.2% of all tested lungs with range of 82 to 98% on farm level. Mean lung lesion score (LLS) obtained for all farms was 11.5 (8.04–14.4). Significant difference for LLS and significantly higher percentage of severe LLS grade (>10) were found among some of the farms (p<0.001). In conclusion, high seroprevalence to Mhyo in finishing pigs in most of the farms was most likely due to vaccination. Farms with higher seroprevalence to Mhyo obtained lower LLS. Serology monitoring of different pig categories and lung assessment at slaughterhouse is a practical tool for assessing vaccine efficacy of Mhyo in pig farms.
Challenges in the diagnosis of leptomeningeal dissemination of glioblastoma in a patient with fever and xanthochromic CSF: a case report
Authors: Neagu Andrei , Niculae Cristian-Mihail , Lăpădat Irina , Hristea Adriana 
Published: May 2023

Abstract

Background
Leptomeningeal spread with carcinomatous meningitis is a severe complication of glioblastoma, with a poor prognosis. Diagnosis is challenging, as the sensitivity of classic diagnostic investigations remains low for detecting cerebrospinal fluid (CSF) tumor spread and exclusion of infectious causes is mandatory, especially if unusual clinical findings are present.

Case presentation
A 71-year-old woman was admitted to our hospital for recurrent episodes of high fever and xanthochromic meningitis, with subacute onset. Her past medical history was significant for a left temporal glioblastoma, treated with surgical resection and adjuvant chemo- and radiotherapy, with associated systemic immunosuppression secondary to chemotherapy. An extensive workup especially with molecular microbiology testing for exclusion of infectious causes was performed. CSF was analyzed for typical bacterial and viral causes, but also pathogens associated with immunosuppression, such as Listeria monocytogenes and Cryptococcus neoformans. A therapeutic trial of standard antituberculous drugs with repeated lumbar punctures were needed in order to exclude Mycobacterium tuberculosis and to confirm the diagnosis of carcinomatous meningitis by cytopathological examination of the CSF.

Conclusions
The case describes an unusual clinical presentation of a patient with glioblastoma associated leptomeningeal dissemination, as high fever and xanthochromic CSF could raise important diagnostic and therapeutic challenges in the clinical practice. The diagnosis of carcinomatous meningitis requires an extensive workup for exclusion of infectious causes which is important for urgent oncologic treatment.
The correlation between Body Mass Index and histological features of Nonalcoholic Fatty Liver Disease
Authors: Calin-Necula Ana , Enciu Vlad , Ologeanu Priscila , Moldoveanu Alexandru Constantin , Braticevici Carmen Fierbinteanu 
Published: May 2023

Abstract

Introduction: NAFLD is strongly associated with metabolic syndrome, and for many years, fatty liver was an exclusive feature of obese patients. The study tries to assess whether the body mass index (BMI) and body circumference is correlated to steatosis, fibrosis, or inflammatory activity of the liver.

Methods: 81 patients with recent hepatic biopsy were included in the study and were weighed and measured. The biopsy results were compared to the measurements.

Results: The average BMI overall for the whole lot was 30.16. There was a significant difference in BMI across the inflammatory activity categories (p = 0.009): groups with higher necro inflammatory activity tended to have higher BMI values (average values per grade: 0–28, 1–29, 2–33, 3–32, 4–29). There was no significant difference for grades of steatosis (p = 0.871). With regards to waist circumference, the overall average was 90.70cm/35.70in. There was a significant difference across the steatosis categories (p < 0.001): groups with higher steatosis scores had higher waist circumferences (average values per grade: 1–77cm / 30 in, 2–95 cm / 37 in, 3–94 cm / 37 in). There was no significant difference for grades of activity (p = 0.058).

Conclusion: BMI and waist circumference are easy to measure, non-invasive parameters, which could be useful in screening patients at higher risk for necro inflammatory activity or severe steatosis.
Neue Hieracium-Taxa aus dem Burgenland (Österreich)
Authors: Gottschlich Günter , Brandstätter Gerald 
Published: May 2023

Abstract
Two species (Hieracium sibaricum, H. pillii) and 3 subspecies (H. diaphanoides subsp. semiorbiculare, H. glaucinum subsp. semibasalticum, H. glaucinum subsp. domimontis) are described as new for science from the Burgenland (Austria).
<p>El punto....sobre la puntuación</p>
Authors: GUELLOUZ HELA 
Published: May 2023

El propósito de este trabajo viene motivado por haber constatado la falta de una enseñanza idónea del sistema de puntuación en la clase de español como lengua extranjera (E/LE) en el contexto tunecino, a pesar de su papel central en la expresión escrita. En efecto, se sigue privilegiando un enfoque tradicional basado en la mera presentación de una lista de normas que el alumno tiene que ir memorizando sin más. Por tanto, se trata aquí de considerar una perspectiva pragmática de los signos de puntuación en la comunicación escrita y de subrayar el papel que cumple la puntuación para guiar al lector en la interpretación del sentido y en la organización de la información dentro del texto.
BENEFITS OF THE MAGNETIC PROPERTIES OF RAPIDLY QUEENED MICROCRYSTALLINE ALLOYS BASED ON RARE-EARTH METALS
Authors: Манаков Н.А. , Ерёмин А.М. , Чирков Ю.А. 
Published: May 2023

Проведены исследования и анализ гистерезисных свойств микрокристаллических быстрозакаленных сплавов SmCo5, GdСо5, Nd2Fe14B с размером кристаллитов 1-5 мкм, меньшим критического размера однодоменности. Характерной особенностью этих сплавов являются неустойчивые магнитные состояния после термического размагничивания и размагничивания обратным полем. Установлена связь метастабильного магнитного состояния микрокристаллических сплавов после термического размагничивания и эффекта их термического намагничивания с основным механизмом перемагничивания и размером кристаллитов. Показано, что в отличие от магнитостатической природы в текстурированных порошковых магнитах, эффект термического намагничивания в структурно изотропных быстрозакаленных сплавах связан исключительно с обменным взаимодействием по границам кристаллитов. Благодаря оптимальному размеру кристаллитов перемагничивание рассматриваемых микрокристаллических сплавов осуществляется путем образования обратных доменов в достаточно высоких полях из-за большой магнитокристаллической анизотропии, что обеспечивает рекордно высокие значения коэрцитивной силы этих сплавов.
Research and analysis of the hysteresis properties of microcrystalline rapidly quenched SmCo5, GdCo5, Nd2Fe14B alloys with a crystallite size of 1-5 μm, which is smaller than the critical size of single-domainness, has been carried out. A characteristic feature of these alloys are unstable magnetic states after thermal magnetization and demagnetization by a reverse field. A relation has been established between the metastable magnetic state of microcrystalline alloys after thermal demagnetization and the effect of their thermal magnetization with the main magnetization reversal mechanism and crystallite size. It is shown that, in contrast to the magnetostatic nature in textured powder magnets, the effect of thermal magnetization in structurally isotropic rapidly quenched alloys is associated exclusively with the exchange interaction along the boundaries of crystallites. Due to the optimal size of crystallites, the magnetization reversal of the considered microcrystalline alloys is carried out by the formation of reverse domains in sufficiently high fields due to the large magnetocrystalline anisotropy, which ensures record high values of the coercive force of these alloys.
STUDY OF THE COMPLEX OF ACTIVE FILLERS FOR MECHANICAL PROPERTIES OF UHMWPE
Authors: Васильев А.П. , Данилова С.Н. , Дьяконов А.А. , Охлопкова А.А. , Оконешникова А.В. , Макаров И.С. 
Published: May 2023

Одним из направлений развития современного материаловедения является разработка полимерных композиционных материалов с улучшенным комплексом свойств. Актуальной задачей является поиск оптимальных составов, благодаря которым определяются свойства, получаемых материалов. В данной работе приводятся результаты исследования влияния комплексных наполнителей, состоящих из сульфенамида, серы, оксидов магния и цинка, на физико-механические свойства и структуру полимерных композиционных материалов на основе сверхвысокомолекулярного полиэтилена (СВМПЭ). Результаты физико-механических исследований показали, что введение комплекса наполнителей “1 мас.% сульфенамида+1 мас.% серы+1 мас.% оксида магния” в СВМПЭ приводит к повышению прочности при растяжении на 23 % по сравнению с исходным полимером. Введение комплексных наполнителей увеличивает сопротивление сжатию до 33 % при относительной деформации 10%. Установлено, что введение комплексных наполнителей в СВМПЭ приводит к образованию сферолитных образований в надмолекулярной структуре. Методом ИК-спектроскопии показано, что происходит сохранение основных пиков исходного полимера. Разработанные материалы могут применяться в качестве уплотнителей в узлах трения машин и техники благодаря улучшенным физико-механическим свойствам.
One of the directions in the development of modern materials science is the development of polymer composite materials with an improved set of properties. An urgent task is to find the optimal compositions, due to which the properties of the obtained materials are determined. This paper presents the results of studying the effect of complex fillers consisting of sulfenamide, sulfur, magnesium and zinc oxides on the mechanical properties and structure of polymer composite materials based on ultra-high molecular weight polyethylene (UHMWPE). The results of physical and mechanical studies showed that the introduction of a complex of fillers “1 wt.% sulfenamide + 1 wt.% sulfur + 1 wt.% magnesium oxide” in UHMWPE leads to an increase in tensile strength by 23% compared to the original polymer. The introduction of complex fillers increases the compressive strength up to 33% at a relative deformation of 10%. It has been established that the introduction of complex fillers into UHMWPE leads to the formation of spherulite formations in the supramolecular structure. It has been shown by IR spectroscopy that the main peaks of the initial polymer are retained. The developed materials can be used as sealants in friction units of machines and equipment due to improved mechanical properties.
PROMISING ROCKET FUEL COMPONENTS. I. OXIDIZERS (REVIEW)
Authors: Верещагин А.Л. 
Published: May 2023

Обзор посвящен современному состоянию разработок бесхлорных окислителей твердого ракетного топлива по состоянию на 1.01.2023.
The review is devoted to the current state of development of chlorine-free oxidizers of solid rocket fuel as of 1.01.2023.
ANALISIS PENGARUH KINERJA KEUANGAN PERBANKAN TERHADAP HARGA SAHAM PT. BANK RAKYAT INDONESIA, TBK
Authors: Amala Ovi , Fisabilillah Ladi Wajuba Perdini 
Published: May 2023

Tujuan dari penelitian ini adalah untuk mengetahui secara parsial dan secara simultan apakah kinerja keuangan perbankan dengan variabel CAR, NPL, ROA, LDR mempengaruhi perkembangan harga saham pada PT. Bank Rakyat Indonesia, Tbk tahun 2008-2020. Data yang digunakan merupakan data sekunder berupa laporan keuangan tahunan pada PT. Bank Rakyat Indonesia, Tbk selama 13 tahun, dengan periode triwulanan mulai tahun 2008-2020. Sampel yang digunakan adalah perbankan BUMN dengan liquiditas yang tinggi yakni PT. Bank Rakyat Indonesia, Tbk. Uji analisis data yang digunakan yaitu Analisis Regresi berupa data time series dengan Eviews 10. Pengujian termasuk juga Uji Asumsi Klasik berupa Uji Normalitas, Uji Autokorelasi, Uji Multikolinieritas, Uji Heterokedastisitas serta Uji Regresi Linier Berganda berupa Uji F simultan dan Uji T parsial. Pada hasil penelitian menunjukkan bahwa variabel CAR, NPL, ROA dan LDR secara bersama-sama berpengaruh terhadap harga saham sebesar 87,47 %. Secara parsial variabel CAR dan ROA berpengaruh secara positif signifikan, sedangkan variabel LDR berpengaruh positif tidak signifikan, untuk variabel NPL berpengaruh secara negatif dan signifikan terhadap saham.
PENGARUH PERTUMBUHAN EKONOMI, UPAH MINIMUM, DAN PENGANGGURAN TERHADAP KEMISKINAN DI KABUPATEN LAMONGAN
Authors: Hanifah Siti , Hanifa Nurul 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pertumbuhan ekonomi, upah minimum, dan pengangguran terhadap kemiskinan. Data yang dilakukan pada saat penelitian ini yaitu data sekunder yang didapat dari instansi terkait yaitu BPS di Kabupaten Lamongan dengan periode triwulan dari tahun 2010 sampai pada tahun 2020. Metode analisis data yang dipakai untuk penelitian ini yaitu model regresi linier berganda dengan bantuan software eviews 10. Hasil studi memperlihatkan variabel pertumbuhan ekonomi, upah minimum, dan pengangguran mempengaruhi bersama-sama positif signifikan terhadap kemiskinan. Secara parsia variabel pertumbuhan ekonomi, dan upah minimum mempengaruhi negatif signifikan terhadap kemiskinan. Tetapi variabel pengangguran mempengaruhi negatif dan tidak signifikan terhadap kemiskinan.
Sektor Basis Kabupaten Ngawi Berbasis Sistem Informasi Geografis
Authors: Widyaningrum Eka Dyah Ayu , Cahyono Hendry 
Published: May 2023

Peta secara sederhana merupakan gambar wilayah dimana informasi yang disajikan berupa bentuk simbol-simbol. Peta disajikan untuk memberikan informasi terkait batas wilayah, sarana prasarana, dan penggunaan lahan. Dengan adanya pemetaan sektor basis di Kabupaten Ngawi diharapkan dapat digunakan sebagai bahan dalam perencanaan pembangunan di Kabupaten Ngawi. Penelitian ini dilakukan menggunakan alat analisis Location Quotient (LQ) dan Shift Share. Data yang digunakan berupa Produk Domestik Regional Bruto Kabupaten Ngawi pada tahun 2015-2019 yang diperoleh dari Badan Pusat Statistika. Pemetaan data diolah menggunakan software ArcGis. Hasil analisis menujukkan bahwa sektor basis di Kabupaten Ngawi terdiri dari sektor pertanian, sektor pengangkutan dan komunikasi, sektor jasa-jasa.
Analisis Pengaruh PDRB, Jumlah Penduduk, Upah Minimum Terhadap Pengangguran di Kabupaten/Kota Provinsi Jawa Timur
Authors: Zuliasari Siti , Rachmawati Lucky 
Published: May 2023

This research goals to look at and break down the impact of GDP, populace, and the lowest pay permitted by law on joblessness in East Java Province in 2015/2019. The technique utilized is quantitative strategy with an exoplanatory approach. The kind of information utilized in this investigation is board information sourced from the Central Statistics Agency (BPS) of East Java Province. The aftereffects of this examination demonstrated that GDP has a critical negative relationship to the variable joblessness in East Java. While the populace and the lowest pay permitted by law have no huge impact on the joblessness variable in East Java. This is shown from the likelihood estimation of the two factors higher than the genuine level (α = 5%). In view of synchronous test outcomes indicated that together autonomous factors specifically GDP, populace, and the lowest pay permitted by law influence joblessness in the Regency/City of East Java Province.

Keywords: Unemployment, GRDP, Population, Minimum Wage
Pengaruh Pertumbuhan Ekonomi, IPM dan Pengangguran Terhadap Tingkat Kemiskinan di Provinsi Jawa Barat
Authors: Dewantari Ni Nyoman Anggie , Rachmawati Lucky 
Published: May 2023

This study aims to see the effect of economic growth, HDI and unemployment onthe poverty rate in West Java province in 2015-2019. Data obtained from theCentral Statistics Agency (BPS) and other sources that support the preparation ofthis research. The method used in this study is to use the panel data method withthe help of Eviews 9 software. Combined data panel between time series data inthe form of time sequences used is 2015-2019 and cross section data, namely in theform of cross-section sequence, namely in the form of 27 districts in West JavaProvince. Based on the results of the analysis, it shows that Economic Growth, HDIand Unemployment partially affect the level of poverty in West Java Province.
Keywords: Economic Growth, Human Development Index, Unemployment andPoverty Level