bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Mooring System for Floating Offshore Wind Turbines: Theory, Design and Industrialization
Authors: Wu Yongyan , Leitch Peter , Pedersen Skule , Nærum Even 
Published: April 2023

Abstract
There are technical and commercial challenges in the mooring of floating offshore wind turbines (FOWTs). Currently, the industry is developing some innovative mooring designs and new mooring components to reduce mooring costs, increase installation and hook-up effectiveness and ultimately reduce the environmental impact.
We propose a new mooring design, the V-Share mooring system, with two lines connecting from two different floater columns to one anchor. Each mooring cluster is "V-shaped," looking down from the sea surface. An anchor attached to multiple mooring lines has been field proven with mooring lines from different floaters sharing anchors. Therefore, all mooring components and installation technologies are field-proven. Numerical simulations verify the effectiveness of the V-Share mooring. Different engineering aspects are discussed, including mooring installation and floater hook-up.
We started with the theoretical analysis for a spread mooring system stiffness in the surge, sway, and yaw directions to demonstrate that the restoring stiffness from the V-Share mooring, as a new system, is comparable to the traditional mooring. Numerical tools further verify this through the restoring stiffness numerical calculations. The comparisons show that the V-Share mooring provides similar horizontal and vertical restoring stiffness and higher yaw stiffness than the traditional moorings. In the case studies, we used one polyester rope semi-taut mooring system and one wire rope catenary mooring system on three-column semi-submersibles with large wind turbines to conduct fully-coupled simulations. The results confirm the similar tension, offsets, and more stable platform motions in the yaw and heel angles. In addition, the V-Share mooring system allows the possibility of hooking up two lines simultaneously. For each FOWT, the V-Share mooring pattern reduces the mooring system footprint and anchor number and achieves savings in CAPEX, geotechnical surveys, transportation, and installation. Moreover, the V-Share mooring is naturally feasible for shared anchors between different floaters in a wind farm, further reducing project costs.
The FOWTs are moving into deeper waters with larger turbines. Multiple mooring lines and large mooring sizes present significant technical and commercial challenges. The V-Share mooring pattern reduces floater motions, mooring footprint, and the number of anchors. It allows for simplified installation procedures and has the potential to improve wind power generation efficiency. The V-Share mooring system can be combined with innovative mooring components or materials to reduce costs further and is also applicable for floaters in other industries such as floating solar or fish farming.
How an Autonomous Offshore Power System Can Transform the Ocean Economy - A Hypothetical Case Study Utilizing an Autonomous Offshore Power System in Northern Lights Carbon Capture and Storage Project
Authors: Slorach Paul , Lesemann Reenst , Leung Pak 
Published: April 2023

Abstract
An Autonomous Offshore Power System (AOPS) provides in-situ power, energy storage, real-time data and communications support, asset management, and other capabilities at sea. It has applications for all offshore industries: energy, defense and security, aquaculture, science and research, and communications. This paper highlights how an AOPS can reduce cost, complexity, and carbon-intensity for existing offshore operations and enable new capabilities for offshore industry leaders.
This new AOPS technology has two primary advantages. First, it unlocks the autonomous, electric future of the ocean economy via ‘local’ power generation and energy storage, in addition to real-time connection to the data cloud. Second, it helps enable a material change in the global energy mix through cost-effective, reliable generation and storage technology for use cases including mobile/static data-gathering and reporting systems, operating equipment, and charging networks for uncrewed surface vessels. AOPS technology will help transform the ocean economy, and thus has implications for offshore industry leaders as they push to reduce costs today and make an autonomous and decarbonized future possible.
A SeaRAY AOPS, which is the focus of this paper, consists of three primary components: C-Power’s SeaRAY surface wave power systemA non-complex, combined mooring, data communications, and power systemVerlume’s Halo seafloor energy storage and intelligent energy management system
The following paper highlights both a real-world and hypothetical deployment of a SeaRAY AOPS, demonstrating its ability to benefit a diverse array of activity in the ocean economy. First, the paper details the work of C-Power and Verlume, in partnership with the U.S. Navy, U.S. Department of Energy, Saab, R2Sonic, Hibbard Inshore, and other industry leaders, to deploy an AOPS at the Wave Energy Test Site in Hawaii for six months, beginning in the first half of 2023. The Hawaii AOPS will power multiple mobile and static assets capable of delivering persistent, self-contained, and self-powered intelligence, surveillance, and reconnaissance (ISR) and reporting capabilities for 24x7x52 maritime defense and border security. The ability to support this use case demonstrates AOPS applicability across a wide variety of offshore applications. Second, the paper explores a theoretical use case to deploy AOPS technology to reduce capital and operational costs and carbon emissions, as well as reduce operational complexity, at the Northern Lights carbon sequestration facility located off the Norwegian coast. While the case study examines the Northern Lights greenfield opportunity using an AOPS in lieu of a power and data umbilical, brownfield upgrades or replacements of failed/failing umbilicals are equally applicable scenarios.
Development of C1q Affinity Chromatography for the Study of C1q–IgG Interactions
Authors: Marshall Michael J E , Knaupp Alexander , Spick Christian , Koese Ilker , Maier Maria , Cragg Mark S , Cymer Florian , Schlothauer Tilman 
Published: April 2023

Abstract
The classical complement system represents a central effector mechanism of Abs initiated by the binding of C1q to target bound IgG. Human C1q contains six heterotrimeric globular head groups that mediate IgG interaction, resulting in an avidity-driven binding event involving multiple IgG molecules binding a single C1q. Accordingly, surface bound IgG molecules are thought to assemble into noncovalent hexameric rings for optimal binding to the six-headed C1q. To study the C1q–Fc interaction of various Abs and screen for altered C1q binding mutants, we developed, to our knowledge, a novel HPLC-based method. Employing a single-chain form of C1q representing one C1q head group, our HPLC methodology was able to detect the interaction between the single-chain monomeric form of C1q and various ligands. We show that, despite a narrow window of specific binding owing to the low affinity of the monomeric C1q–IgG interaction, this approach clearly distinguished between IgG subclasses with established C1q binding properties. IgG3 displayed the strongest binding, followed by IgG1, with IgG2 and IgG4 showing the weakest binding. Fc mutants known to have increased C1q binding through oligomerization or enhanced C1q interaction showed greatly increased column retention, and IgG glycovariants displayed a consistent trend of increasing retention upon increasing galactosylation and sialylation. Furthermore, the column retention of IgG isotypes and glycovariants matches both the cell surface recruitment of C1q and complement-mediated cytotoxicity induced by each variant on an anti-CD20 Ab backbone. This methodology therefore provides a valuable tool for testing IgG Ab (glyco)variants for C1q binding, with clear relevance for therapeutic Ab development.
Evaluation of serum levels of vitamin D and CXCL10 in patients with generalized vitiligo and their relation to disease severity
Authors: Seddik Mohamed I. , Mekkawy Marwa M. , Shehata Rofaida R. 
Published: April 2023

Background
Vitiligo is an acquired, common, autoimmune, pigmentary defect of the skin. Vitamin D (VitD) plays a physiological role in photo-induced melanogenesis in the skin. It was found that VitD levels decline in autoimmune illnesses. Recently, there has been growing interest in the role of vitamin D3 in the pathogenesis of vitiligo and its change after treatment. The chemokine CXCL10 was found to be raised in the serum of patients with vitiligo. Few studies have evaluated its relation to the severity of the disease.

Aims
To establish a link between both serum VitD and serum CXCL10 and vitiligo, besides evaluating their possible relation to disease severity.

Patients and methods
This study was conducted on 30 patients with generalized vitiligo and 30 healthy individuals without age and sex limitations. Serum VitD and CXCL10 levels were measured for both patients with vitiligo and controls and were re-evaluated after 12 weeks for patients with vitiligo. The Vitiligo Area Scoring Index was calculated for the patient group at baseline and after 12 weeks.

Results
Serum VitD was found to be significantly lower in patients with vitiligo than controls, whereas serum CXCL10 was significantly higher in patients than healthy controls. Changes in serum CXCL10 at the end of the study period positively correlated with changes in Vitiligo Area Scoring Index of patients with vitiligo.

Conclusion
There is a strong relationship between both serum VitD and CXCL10 and vitiligo. Serum CXCL10 levels change in relation to disease severity.
Do Egyptian children with beta-thalassemia major have specific cutaneous manifestations? A cross-sectional study
Authors: Embaby Mostafa M. , Farag Neveen M. , Badran Aya Y. , Abdel-Karim El Sayed K. 
Published: April 2023

Background
A wide continuum of cutaneous manifestations might accompany blood diseases and hemoglobinopathies, especially β-thalassemia. In this situation, cutaneous manifestations occur due to both hemoglobin disorder and treatment complications. These manifestations are usually neglected and frequently underdiagnosed among those patients.

Aim
To study the cutaneous manifestations in Egyptian children with β-thalassemia to minimize its subsequent complications. Furthermore, we aimed to analyze their relations to duration of disease and frequency of blood transfusions and other disease parameters.

Patients and methods
This was a cross-sectional study that included 158 patients with β-thalassemia major. All patients were subjected to detailed history, clinical examination, and laboratory investigations, namely, serum ferritin and hemoglobin level. All patients were subjected to meticulous dermatological examination by an experienced dermatologist to evaluate cutaneous manifestations. The data were analyzed using Student t test, Mann–Whitney U test, χ
2 test, and Fisher exact test.

Results
Xerosis was the commonest encountered cutaneous change (present in 61% of patients), followed by hyperhidrosis (30%), hyperpigmentation (28%), pruritus and pityriasis alba (25%), urticaria (22%), and idiopathic guttate hypomelanosis, scars, ephelides, contact dermatitis, discoid eczema, nail disorders, melasma, tinea, alopecia areata, and warts in descending order. Statistically significant relations were present between the presence of some cutaneous manifestations and disease duration.

Conclusion
Cutaneous manifestations are common among Egyptian children with β-thalassemia major. Both xerosis and hyperhidrosis are the commonest cutaneous signs in those patients. Some of those cutaneous manifestations are correlated with disease duration and frequency of blood transfusions.
Efficacy of combination therapy with microneedling and topical latanoprost 0.005% in treatment of acrofacial vitiligo
Authors: El-Magid Wafaa M.A. , Mohamed Marwa , Abd-Elghany Noreen I. , Saleh Ramadan 
Published: April 2023

Background
Acrofacial vitiligo (AFV) represents a therapeutic challenge for dermatologists.

Aim and objectives
To investigated the efficacy of microneedling (MN) and topical latanoprost (LT) 0.005% in the treatment of AFV.

Patients and methods
A total of 72 patients with AFV were divided into two groups. Group A (n=36) received topical LT 0.005% twice daily, preceded by MN sessions at 2-week intervals, for a total duration of 12 weeks. Group B (n=36) received topical LT 0.005% alone for 12 weeks. Participants were evaluated by vitiligo area and severity index (VASI) at 2-week intervals for 12 weeks, and at 12 weeks after stopping the treatment.

Results
In group A, 12-week VASI [0.45 (0.18, 0.64)] was significantly lower than the baseline VASI [0.5 (0.21, 0.67); P=0.003]. In group B, the 12-week VASI was the same as the baseline VASI [0.43 (0.25, 1)]. Repigmentation was achieved in 18/36 (50%) of patients in group A and 0/36 (0.0%) in group B. Repigmentation was rated as excellent in 2/36 (5.56%), very good in 2/36 (5.56%), good in 4/36 (11.12%), and fair in 10/36 (27.76%) of the cases.

Conclusion
Combined therapy with MN and topical LT 0.005% resulted in variable degrees of repigmentation in 50% of patients with AFV.
A Re-Examination of the Patterns of Foot and Ankle Deformities in Congenital Limb Deficiencies
Authors: Kothari Alpesh , Kelley Simon P. , Bouchard Maryse 
Published: April 2023

Purpose:
The aim of this study is to evaluate foot deformities and anomalies present in congenital limb deficiencies (CLDs). We sought to define the relationship between the type of limb deficiency and foot posture, patterns of ray deficiencies, and association between tarsal coalition (TC) and ball-and-socket ankle.

Materials and Methods:
This is a single institution, retrospective radiograph, and medical record review of patients with CLD, comprising congenital femoral deficiency (CFD), tibial hemimelia (TH), and fibular hemimelia (FH) from January 2000 to January 2019. Data extracted included patient demographics, predicted leg length discrepancy, associated deformities and anomalies, and specifics of the foot deformity. Surgical procedures were recorded. Data were reported using descriptive statistics. Fisher's exact test analyses of contingency tables were used for the exploratory components of this study.

Results:
Eighty-one patients with 97 limb deficiencies were identified (16 – CFD, 18 – TH, and 63 – FH). Isolated CFD was not associated with foot and ankle deformity and TH was associated with an equinocavovarus foot in all limbs. In FH, an equinocavovarus deformity was present in 15/63 (24%) feet, most requiring foot surgery. Of 48 patients with FH and absent rays, two lacked lateral rays, whereas the remainder missed one or more intermediate rays. TC was unrelated to the presence of ball-and-socket ankle.

Conclusions:
This study demonstrates heterogeneity in the spectrum of foot and ankle deformity in CLD, particularly in FH. Recognition of this phenotypic variation is critical for surgeons to formulate a comprehensive treatment plan and ensure optimal functional outcomes. Level of Evidence: IV.
Effect of Axial Dynamization in Circular External Fixation on Bone Segment Vertical and Lateral Displacements
Authors: Honcharuk Erin M. , Cherkashin Alexander M. , Pierce William A. , Jo Chanhee , Podeszwa David A. , Samchukov Mikhail L. 
Published: April 2023

Context:
The field of deformity correction with external fixation has continued to advance since with the addition of half-pins, even though they can act to stiffen the construct and undermine healing. Dynamization increases axial motion at the fracture site and improves fracture and osteotomy healing in the experimental and clinical studies. No study compares the lateral and vertical displacements of bone segment in dynamized versus nondynamized frames.

Aims:
The purpose of this study was to compare the segmentary motion in the axial, coronal, and sagittal planes using nondynamized and dynamized circular external fixation frames.

Subjects and Methods:
Seven frame models were tested including classic Ilizarov three-wire construct and two frame configurations representing the most common modern half-pin and wire combinations. These models were either nondynamized or dynamized with two types of dynamization modules. Each model underwent axial loading up to 50 kg for 11 cycles.

Statistical Analysis Used:
One-way analysis of variance testing followed by post hoc Tukey's test.

Results:
The addition of each half pin sequentially decreased axial motion while increased sagittal motion. Dynamization had a limited effect on the sagittal motion but significantly improved axial motion. The sagittal to axial motion ratio increased with half pins in nondynamized frames but decreased equal to or beyond the Ilizarov three-wire fixation frame with dynamization. At the limit of the dynamizers' motion, there was change in the rate of displacement, suggesting that subsequent motion was strictly from the wires and half-pins. Overall, there was minimal coronal motion.

Conclusions:
While half pins decrease axial micromotion and increase detrimental sagittal motion, dynamization restores.
Correlation between Use of the Contraception and Exclusive Breastfeeding in Indonesia in 2017 (2017 Indonesian Demographic and Health Survey analysis data)
Authors: Putri Febrianti Prasmono , Katmawanti Septa , Fanani Erianto 
Published: April 2023

Background:
Breast milk is the first need for a newborn baby. Infants aged 0–6 months who are breastfed without any other food define exclusive breastfeeding. Exclusive breastfeeding can be influenced by several factors, one of which is contraception. Inappropriate use of contraception can affect exclusive breastfeeding.

Aims:
This study aimed to determine the correlation between contraceptive use and exclusive breastfeeding in Indonesia in 2017.

Materials and Methods:
The research design in this study was descriptive-analytic with a cross-sectional approach. This study examines the population of women of childbearing age who are married and have their last child aged 0–6 months with a total sample of 1891 people, with a sampling technique using total sampling. The data were taken from the results of the 2017 Indonesian Demographic and Health Survey. The data analysis of this study used the Chi-square statistical test.

Result:
The results of data analysis showed that 53% of women of childbearing age used contraception, and 47% of women of childbearing age did not use contraception. Meanwhile, 46% of women of childbearing age gave exclusive breastfeeding, and 54% of women of childbearing age did not give exclusive breastfeeding. The Chi-square test results showed a P = 0.000 (P < 0.05).

Conclusions:
Based on the study results, it can be concluded that there is a correlation between contraceptive use and exclusive breastfeeding in Indonesia in 2017.
Dengue and COVID-19 Co-Circulation in the Peruvian Amazon: A Population-Based Study
Authors: Pons Maria J. , Mayanga-Herrera Ana , Ulloa Gabriela M. , Ymaña Barbara , Medina Sabrina , Alava Freddy , Álvarez-Antonio Carlos , Meza-Sánchez Graciela , Calampa Carlos , Casanova Wilma , Carey Cristiam , Rodríguez-Ferrucci Hugo , Morrison Amy C. , Quispe Antonio M. 
Published: April 2023

ABSTRACT.
The COVID-19 pandemic affected the main Amazon cities dramatically, with Iquitos City reporting the highest seroprevalence of anti-SARS-CoV-2 antibodies during the first COVID-19 wave worldwide. This phenomenon raised many questions about the possibility of a co-circulation of dengue and COVID-19 and its consequences. We carried out a population-based cohort study in Iquitos, Peru. We obtained a venous blood sample from a subset of 326 adults from the Iquitos COVID-19 cohort (August 13–18, 2020) to estimate the seroprevalence of anti-dengue virus (DENV) and anti-SARS-CoV-2 antibodies. We tested each serum sample for anti-DENV IgG (serotypes 1, 2, 3, and 4) and SARS-CoV-2 antibodies anti-spike IgG and IgM by ELISA. We estimated an anti-SARS-CoV-2 seroprevalence of 78.0% (95% CI, 73.0–82.0) and an anti-DENV seroprevalence of 88.0% (95% CI, 84.0–91.6), signifying a high seroprevalence of both diseases during the first wave of COVID-19 transmission in the city. The San Juan District had a lower anti-DENV antibody seroprevalence than the Belen District (prevalence ratio, 0.90; 95% CI, 0.82–0.98). However, we did not observe these differences in anti-SARS-CoV-2 antibody seroprevalence. Iquitos City presented one of the highest seroprevalence rates of anti-DENV and anti-SARS-CoV-2 antibodies worldwide, but with no correlation between their antibody levels.
Treatment of Cutaneous Leishmaniasis with Allopurinol Plus Itraconazole in Iran
Authors: Mashayekhi Goyonlo Vahid , Derakhshan Zahra , Darchini-Maragheh Emadodin 
Published: April 2023

ABSTRACT.
Cutaneous leishmaniasis (CL) is a serious tropical disease and a neglected health challenge in Iran. Although limited data are available regarding anthroponotic CL, cases resistant to meglumine antimoniate (Glucantime) are increasingly being reported. Via an open-label noncontrolled case series, allopurinol (10 mg/kg/day) plus itraconazole (3–4 mg/kg/day) were orally administered for 1 month to 27 patients (56 lesions) with anthroponotic CL, most of whom were resistant to Glucantime. A mean lesion size of 3.5 ± 1.9 cm at baseline was reduced to 0.6 ± 1.0 after 1 month of treatment. Excellent treatment response was observed in 85.7% of lesions after 1 month. Recurrence only occurred in one patient in the 3-month follow-up session. This study presents preliminary evidence that oral allopurinol plus itraconazole could be an effective treatment in patients with anthroponotic CL.
Effects of Pre-Storage Treatments on Sprouting and Nutritional Quality of Ginger (ZingiberofficinaleRosc) Rhizomes in Different Storage Periods
Authors: Olakunle Prof Olaniyi Joel , Olusoga Stephen , Batola A. L. , Atanda T. T. 
Published: April 2023

Purpose: Ginger rhizomes are highly susceptible to damage during postharvest storage due to soil borne pathogenic disorder. Experiments were conducted to evaluate the effects of pre-storage treatments required for sprouting and maintaining the quality of ginger plant in different storage periods at the Teaching and Research Farm, Ladoke Akintola University of Technology, Ogbomoso.Method: The rhizomes were treated with four different pre-storage treatments viz.,control, hydrated lime, - Mancozeb, and 100ml of Trichodermaharzianum solution at different storage periods of one, two and three months. The experiment was arranged in a complete randomized designand laid out in a randomized complete block design with three replicates. Data were collected on percentage sprouting, plant height, number of leaves, leaf area and nutritional quality of ginger rhizomes. Data were subjected to analysis of variance using Statistical Analysis System Software (SAS, 2005). Differences among treatment means were compared using Least Significance Difference (LSD) at 5% probability level.Results: The storage periods significantly (P≤0.05) influenced the percentage sprouting andgrowth parametersof ginger at various sampling period. Highest growth of 9.05cm was recorded from ginger plant stored for three months while the least value of 6.94cm was obtained from rhizomes stored for one month. The pre-storage treatments significantly (P≤0.05) influenced the percentage sprouting, weight loss and growth parameters of ginger at various sampling period. Highest percentage sprouting (94.3%) was recorded from rhizomes treated with 100 ml Trichodermaharzianim solution followed by rhizomes treated with hydrated lime (88.3 %) while lowest percentage sprouting (61.5 %) were recorded from control. Highest percentage weight loss of 46.3% was recorded from control followed by hydrated lime (35.58 %) while the lowest percentage weight loss of 33.93 % was recorded from 100 ml Trichodermaharzianim solution.Conclusions: In conclusion, rhizomes treated with Trichodermaharzianimsolution for a period of three months before planting produced better sprouting and enhanced the growth quality of ginger on the field.