bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuning Hydrophobicity of Paper Substrates for Effective Colorimetric detection of Glucose and Nucleic acids
Authors: Sudarsan Sujesh , Shetty Prashil , Chinnappan Raja , Mani Naresh Kumar 
Published: September 2023

AbstractThis study investigated the colorimetric response of standard glucose, serum glucose, and nucleic acid assays on various paper surfaces with different wettability, including hydrophilic, hydrophobic, and nearly superhydrophobic surfaces. Water contact angles (WCA) formed by water droplets on each surface were measured using ImageJ software. The hydrophilic surface showed no contact angle, while the hydrophobic and nearly superhydrophobic surfaces exhibited contact angles of 115.667° and 133.933°, respectively. The colorimetric sensitivity of the standard glucose assay was analyzed on these surfaces, revealing enhanced sensitivity on the nearly superhydrophobic surface due to the high molecular crowding effect owing to its non-wetting behavior and eventually confined reaction product at the sample loading zone. The hydrophobic nature of the surface restricts the spreading and diffusion of the reaction product, leading to a controlled and localized concentration of the assay product leading to moderate colorimetric intensity. On the other hand, the hydrophilic surface showed the least enhancement in colorimetric sensitivity; this is attributed to the high wettability of the hydrophilic surface causing the reaction product to spread extensively, resulting in a larger area of dispersion and consequently a lower colorimetric intensity. The measured limit of detection (LOD) for nucleic acid on nearly superhydrophobic surfaces was found to be 16.15 ng/µL, which was almost four-fold lower than on hydrophilic surfaces (60.08 ng/µL). Additionally, the LODs of standard glucose and clinical serum samples were two-fold lower on nearly superhydrophobic surfaces compared to hydrophilic surfaces. Our findings clearly highlight the promising potential of utilizing superhydrophobic surfaces to significantly enhance colorimetric sensitivity in paper-based diagnostic applications. This innovative approach holds promise for advancing point-of-care diagnostics and improving disease detection in resource-limited settings.
Nutrient dynamics, carbon storage and community composition on artificial and natural reefs in Bali, Indonesia
Authors: Boakes Zach , Suryaputra I. Gusti Ngurah A. , Hall Alice E. , Franklin Daniel J. , Stafford Richard 
Published: September 2023

AbstractArtificial reefs are now commonly used as a tool to restore degraded coral reefs and have a proven potential to enhance biodiversity. Despite this, there is currently a limited understanding of ecosystem functioning on artificial reefs, and how this compares to natural reefs. We used water sampling (bottom water sampling and pore water sampling), as well as surface sediment sampling and sediment traps, to examine the storage of total organic matter (as a measure of total organic carbon) and dynamics of dissolved inorganic nitrate, nitrite, phosphate and ammonium. These biogeochemical parameters were used as measures of ecosystem functioning, which were compared between an artificial reef and natural coral reef, as well as a degraded sand flat (as a control habitat), in Bali, Indonesia. We also linked the differences in these parameters to observable changes in the community structure of mobile, cryptobenthic and benthic organisms between habitat types. Our key findings showed: (1) there were no significant differences in inorganic nutrients between habitat types for bottom water samples, (2) pore water phosphate concentrations were significantly higher on the artificial reef than on both other habitats, (3) total organic matter content in sediments was significantly higher on the coral reef than both other habitat types, and (4) total organic matter in sediment traps in sampling periods May and September were higher on coral reefs than other habitats, but no differences were found in November. Overall, in terms of ecosystem functioning (specifically nutrient storage and dynamics), the artificial reef showed differences from the nearby degraded sand flat, and appeared to have some similarities with the coral reef. However, it was shown to not yet be fully functioning as the coral reef, which we hypothesise is due its relatively less complex benthic community and different fish community. We highlight the need for longer term studies on artificial reef functioning, to assess if these habitats can replace the ecological function of coral reefs at a local level.
Whole-genome sequencing and antimicrobial potential of bacteria isolated from Polish honey
Authors: Hafeez Ahmer Bin , Pełka Karolina , Buzun Kamila , Worobo Randy , Szweda Piotr 
Published: September 2023

Abstract
The aim of this study was the whole-genome analysis and assessment of the antimicrobial potential of bacterial isolates from honey harvested in one geographical location—the north of Poland. In total, 132 strains were derived from three honey samples, and the antimicrobial activity of CFAM (cell-free after-culture medium) was used as a criterion for strain selection and detailed genomic investigation. Two of the tested isolates (SZA14 and SZA16) were classified as Bacillus paralicheniformis, and one isolate (SZB3) as Bacillus subtilis based on their ANI and phylogenetic analysis relatedness. The isolates SZA14 and SZA16 were harvested from the same honey sample with a nucleotide identity of 98.96%. All three isolates have been found to be potential producers of different antimicrobial compounds. The secondary metabolite genome mining pipeline (antiSMASH) identified 14 gene cluster coding for non-ribosomal peptide synthetases (NRPs), polyketide synthases (PKSs), and ribosomally synthesized and post-translationally modified peptides (RiPPs) that are potential sources of novel antibacterials. The BAGEL4 analysis revealed the presence of nine putative gene clusters of interest in the isolates SZA14 and SZA16 (including the presence of six similar clusters present in both isolates, coding for the production of enterocin Nkr-5-3B, haloduracin-alpha, sonorensin, bottromycin, comX2, and lasso peptide), and four in B. subtilis isolate SZB3 (competence factor, sporulation-killing factor, subtilosin A, and sactipeptides). The outcomes of this study confirm that honey-derived Bacillus spp. strains can be considered potential producers of a broad spectrum of antimicrobial agents.

Key points
• Bacteria of the genus Bacillus are an important component of honey microbiota.
• Honey-derived Bacillus spp. strains are potential producers of new antimicrobials.
Outcomes of Complex Abdominal Wall Reconstruction with Biologic Mesh in Patients with 8 Years of Follow‐Up
Authors: Hassan Abbas M. , Franco Camila M. , Shah Nikhil R. , Talanker Michael M. , Asaad Malke , Mericli Alexander F. , Selber Jesse C. , Butler Charles E. 
Published: September 2023

AbstractBackgroundWhile many studies evaluated outcomes of abdominal wall reconstruction with biologic mesh, long‐term data is lacking. In this study, we sought to analyze the outcomes of complex AWR with biologic mesh in a robust cohort of patients with a mean follow up of 8 years.MethodsWe conducted a longitudinal study of AWR patients from 2005 to 2019. Hernia recurrence was the primary outcome, and surgical site occurrence was the secondary outcome. Predictive/protective factors were identified using a Cox proportional hazards regression models.ResultsWe identified 109 consecutive patients who met the inclusion criteria. Patient's mean (± SD) age was 57.5 ± 11.8 years, mean body mass index was 30.7 ± 7.2 kg/m2, and mean follow‐up time was 96.2 ± 15.9 months. Fifty‐six percent had clean defects, 34% had clean‐contaminated defects, and 10% had contaminated/infected defects. Patients had a mean defect size of 261 ± 199.6 cm2 and mean mesh size of 391.3 ± 160.2 cm2. Nineteen patients (17.4%) developed HR at the final follow‐up date. Obesity was independently associated with a four‐fold higher risk of HR (hazard ratio, 3.98; 95%CI, 1.34 to 14.60, p = 0.02). SSOs were identified in 24.8% of patients. A prior hernia repair was associated with a three‐fold higher risk of SSOs (Odds ratio, 3.13; 95%CI, 1.10 to 8.94, p = 0.03). No patient developed mesh infection.ConclusionThese longitudinal data demonstrate that complex AWR with biologic mesh provides long‐term durable outcomes with acceptable HR and SSO rates despite high contamination levels, patients complexity, and large defect size.
The alliance of genome resources: transforming comparative genomics
Authors: Bult Carol J. , Sternberg Paul W. 
Published: September 2023

AbstractComparing genomic and biological characteristics across multiple species is essential to using model systems to investigate the molecular and cellular mechanisms underlying human biology and disease and to translate mechanistic insights from studies in model organisms for clinical applications. Building a scalable knowledge commons platform that supports cross-species comparison of rich, expertly curated knowledge regarding gene function, phenotype, and disease associations available for model organisms and humans is the primary mission of the Alliance of Genome Resources (the Alliance). The Alliance is a consortium of seven model organism knowledgebases (mouse, rat, yeast, nematode, zebrafish, frog, fruit fly) and the Gene Ontology resource. The Alliance uses a common set of gene ortholog assertions as the basis for comparing biological annotations across the organisms represented in the Alliance. The major types of knowledge associated with genes that are represented in the Alliance database currently include gene function, phenotypic alleles and variants, human disease associations, pathways, gene expression, and both protein–protein and genetic interactions. The Alliance has enhanced the ability of researchers to easily compare biological annotations for common data types across model organisms and human through the implementation of shared programmatic access mechanisms, data-specific web pages with a unified “look and feel”, and interactive user interfaces specifically designed to support comparative biology. The modular infrastructure developed by the Alliance allows the resource to serve as an extensible “knowledge commons” capable of expanding to accommodate additional model organisms.
Integer-valued polynomials on valuation rings of global fields with prescribed lengths of factorizations
Authors: Fadinger-Held Victor , Frisch Sophie , Windisch Daniel 
Published: September 2023

AbstractLet V be a valuation ring of a global field K. We show that for all positive integers k and $$1 < n_1 \le \cdots \le n_k$$

1
<

n
1

≤
⋯
≤

n
k

there exists an integer-valued polynomial on V, that is, an element of $${{\,\textrm{Int}\,}}(V) = \{ f \in K[X] \mid f(V) \subseteq V \}$$

Int

(
V
)
=
{
f
∈
K
[
X
]
∣
f
(
V
)
⊆
V
}

, which has precisely k essentially different factorizations into irreducible elements of $${{\,\textrm{Int}\,}}(V)$$

Int

(
V
)

whose lengths are exactly $$n_1,\ldots ,n_k$$

n
1

,
…
,

n
k

. In fact, we show more, namely that the same result holds true for every discrete valuation domain V with finite residue field such that the quotient field of V admits a valuation ring independent of V whose maximal ideal is principal or whose residue field is finite. If the quotient field of V is a purely transcendental extension of an arbitrary field, this property is satisfied. This solves an open problem proposed by Cahen, Fontana, Frisch and Glaz in these cases.
Dynamic cardiac MRI with high spatiotemporal resolution using accelerated spiral-out and spiral-in/out bSSFP pulse sequences at 1.5 T
Authors: Wang Zhixing , Feng Xue , Salerno Michael , Kramer Christopher M. , Meyer Craig H. 
Published: September 2023

Abstract
Objective
To develop two spiral-based bSSFP pulse sequences combined with L + S reconstruction for accelerated ungated, free-breathing dynamic cardiac imaging at 1.5 T.

Materials and methods
Tiny golden angle rotated spiral-out and spiral-in/out bSSFP sequences combined with view-sharing (VS), compressed sensing (CS), and low-rank plus sparse (L + S) reconstruction were evaluated and compared via simulation and in vivo dynamic cardiac imaging studies. The proposed methods were then validated against the standard cine, in terms of quantitative image assessment and qualitative quality rating.

Results
The L + S method yielded the least residual artifacts and the best image sharpness among the three methods. Both spiral cine techniques showed clinically diagnostic images (score > 3). Compared to standard cine, there were significant differences in global image quality and edge sharpness for spiral cine techniques, while there was significant difference in image contrast for the spiral-out cine but no significant difference for the spiral-in/out cine. There was good agreement in left ventricular ejection fraction for both the spiral-out cine (− 1.6 $$\pm$$
±
3.1%) and spiral-in/out cine (− 1.5 $$\pm$$
±
2.8%) against standard cine.

Discussion
Compared to the time-consuming standard cine (~ 5 min) which requires ECG-gating and breath-holds, the proposed spiral bSSFP sequences achieved ungated, free-breathing cardiac movies at a similar spatial (1.5 × 1.5 × 8 mm3) and temporal resolution (36 ms) per slice for whole heart coverage (10–15 slices) within 45 s, suggesting the clinical potential for improved patient comfort or for imaging patients with arrhythmias or who cannot hold their breath.
The potential of extended reality in Rural Education’s future – perspectives from rural educators
Authors: Wang Xining , Young Gareth W. , Iqbal Muhammad Zahid , Guckin Conor Mc 
Published: September 2023

AbstractTechnology-enhanced education can potentially enhance teaching and learning outcomes for rural educators since they face limited educational resources and low job satisfaction. Recently, there has been a surge in extended reality (XR) as an immersive learning technology to improve teaching and learning in rural areas, but without focusing on rural educators’ perspectives. This study aims to bridge this gap by investigating rural educators’ interactions with XR educational applications and exhibiting their insights on using XR education to improve education quality in rural areas. After educators’ hands-on experiences in a pre-designed XR education workshop, qualitative data was collected from their discussions in focus groups. As a result, educators believed that XR could transform traditional educational practices and create opportunities for new patterns of rural education (e.g., public engagement with rurality and rural vocational education). Limitations include a lack of school infrastructure to apply XR and an absence of well-structured curriculum design to use XR in the classroom setting. We suggest that future studies explore the integration of effective XR practices into primary and elementary education in those areas with limited educational resources.
A Bioeconomic Model of Non-profit and For-profit National Parks Integrating Locals in Biodiversity Conservation
Authors: Xie Zijin , Onuma Ayumi 
Published: September 2023

AbstractTo achieve the conservation goals of national parks, involving locals in park operations provides a win/win approach for local development and wildlife management. However, while some bioeconomic studies examine the effectiveness of biodiversity conservation projects that employ locals, most ignore the direct involvement of local workers in national park operations. Moreover, the existing literature tends to assume that national parks are for-profit organizations, whereas they are generally non-profit entities. In this study, we develop a bioeconomic model to investigate the extent to which involving locals in tourism in a national park managed under two different styles of management (i.e., non-profit and for-profit agencies) influences wildlife conservation. We find certain conditions under which involving locals in national park operations can conserve wildlife. Under these conditions, if wildlife conservation does not reduce agricultural productivity, non-profit agencies raise the utility of locals and promote wildlife conservation more than for-profit agencies. Otherwise, non-profit agencies do not necessarily increase the utility of locals or improve conservation compared with for-profit agencies. In addition, we compare the equilibria under both types of agencies and show that they do not generally achieve the social optimum.
The 12-Step Pathway to Spiritual Growth and Gratitude and Its Relationship With Well-Being Among the Members of Sexaholics Anonymous in Poland
Authors: Wnuk Marcin , Krentzman Amy R. , Charzyńska Edyta 
Published: September 2023

AbstractDespite the well-established role of mutual-aid groups in addiction treatment, no research has yet explored the role of the 12-step pathway in spiritual growth and gratitude, or its direct and indirect relationships with well-being among individuals with compulsive sexual behavior disorders (CSBD). The purpose of the current study was to examine the number of 12 steps completed as an antecedent of spiritual growth and gratitude and its relationship with well-being among members of Sexaholics Anonymous (SA). The sample consisted of 80 individuals (72 men and 8 women) attending SA meetings in Poland. The study variables were measured using the Daily Spiritual Experiences Scale, Gratitude Questionnaire, Satisfaction with Life Scale, Positive and Negative Affect Schedule, and a single question regarding the number of 12 steps completed. A path analysis showed that the number of 12 steps completed was negatively and directly related to negative affect. Moreover, the number of 12 steps completed was related to higher spiritual growth, which was directly related to higher levels of life satisfaction and lower levels of negative affect, and indirectly, through gratitude, to higher levels of life satisfaction and positive affect. The results suggest that spiritual growth, rooted in the 12-step program, and its ability to increase gratitude, may promote recovery from CSBD.
Minimizing the mean slowdown in the M/G/1 queue
Authors: Aalto Samuli , Scully Ziv 
Published: September 2023

AbstractWe consider the optimal scheduling problem in the M/G/1 queue. While this is a thoroughly studied problem when the target is to minimize the mean delay, there are still open questions related to some other objective functions. In this paper, we focus on minimizing mean slowdown among non-anticipating polices, which may utilize the attained service of the jobs but not their remaining service time when making scheduling decisions. By applying the Gittins index approach, we give necessary and sufficient conditions for the jobs’ service time distribution under which the well-known scheduling policies first come first served and foreground background are optimal with respect to the mean slowdown. Furthermore, we characterize the optimal non-anticipating policy in the multi-class case for certain types of service time distributions. In fact, our results cover a more general objective function than just the mean slowdown, since we allow the holding costs for a job to depend on its own service time S via a generic function c(S). When minimizing the mean slowdown, this function reads as $$c(x) = 1/x$$

c
(
x
)
=
1
/
x

.
Burden of diabetes attributable to dietary cadmium exposure in adolescents and adults in China
Authors: Li Shan , Tuerxunyiming Muhadasi , Sun Zhe , Zheng Su-yang , Liu Qing-bai , Zhao Qing 
Published: September 2023

AbstractAt present, the health risk assessment of cadmium exposure has become a major focus of environmental health research. However, there is still a lack of systematic research on the burden of diabetes (DM) attributable to dietary cadmium exposure in adolescents and adults in China. Using the top-down method, the blood cadmium level (B-Cd) of Chinese adolescents and adults from 2001 to 2023 was combined with the relative risk (RR) of cadmium-induced diabetes to calculate the population attribution score (PAF). Subsequently, PAF was used to assess the disease burden (DB) of diabetes caused by cadmium exposure, expressed in disability adjusted life years (DALYs), and attribution analysis was carried out for cadmium exposure from different sources. The average blood cadmium concentration in Chinese adolescents and adults was 1.54 ± 1.13 µg/L, and the burden of DM attributable to cadmium exposure was 56.52 (44.81, 70.33) × 105 DALYs. The contribution rate of dietary cadmium exposure was 59.78%, and the burden of DM attributable to dietary cadmium exposure was 337.86 (267.85, 420.42) × 108 DALYs. In addition, the highest blood cadmium concentrations were found in Henan, Shanxi, and Jiangxi provinces, while the highest burden of DM attributable to cadmium exposure was found in Jiangsu, Henan, and Guangdong provinces. Cadmium exposure is a risk factor for DM, and we need to take comprehensive action to reduce the burden of DM attributable to dietary cadmium from health, economic, and social perspectives.
LungCARE: Encouraging Shared Decision-Making in Lung Cancer Screening—a Randomized Trial
Authors: Walsh Judith M. E. , Karliner Leah , Smith Ashley , Leykin Yan , Gregorich Steven E. , Livaudais-Toman Jennifer , Velazquez Ana I. , Lowenstein Margaret , Kaplan Celia P. 
Published: September 2023

Abstract
Background
Lung cancer screening (LCS) is recommended for individuals at high risk due to age and smoking history after a shared decision-making conversation. However, little is known about best strategies for incorporating shared decision-making, especially in a busy primary care setting.

Objective
To develop a novel tool, Lung Cancer Assessment of Risk and Education (LungCARE) to guide LCS decisions among eligible primary care patients.

Design
Pilot cluster randomized controlled trial of LungCARE versus usual care.

Participants
Patients of providers in a university primary care clinic, who met criteria for LCS.

Intervention
Providers were randomized to LungCARE intervention or control. LungCARE participants completed a computer tablet-based video assessment of lung cancer educational needs in the waiting room prior to a primary care visit. Patient and provider both received a summary handout of patient concerns and responses.

Main Measures
All eligible patients completed baseline interviews by telephone. One week after the index visit, participants completed a follow-up telephone survey that assessed patient-physician discussion of LCS, referral to and scheduling of LCS, as well as LCS knowledge and acceptability of LungCARE. Two months after index visit, we reviewed patients’ electronic health records (EHRs) for evidence of a shared decision-making conversation and referral to and receipt of LCS.

Key Results
A total of 66 participants completed baseline and follow-up visits (34: LungCARE; 32: usual care). Mean age was 65.9 (± 6.0). Based on EHR review, compared to usual care, LungCARE participants were more likely to have discussed LCS with their physicians (56% vs 25%; p = 0.04) and to be referred to LCS (44% vs 13%; p < 0.02). Intervention participants were also more likely to complete LCS (32% vs 13%; p < 0.01) and had higher knowledge scores (mean score 6.5 (± 1.7) vs 5.5 (± 1.4; p < 0.01).

Conclusions
LungCARE increased discussion, referral, and completion of LCS and improved LCS knowledge.

Clinical Trial Registration
NCT03862001.