bluuebunny/crossref_metadata_2025_split huggingface dataset:
FGF-21 Conducts a Liver-Brain-Kidney Axis to Promote Renal Cell Carcinoma
Authors: Li Zongyu , Zhang Xinyi , Zhu Wanling , Zhang Cuiling , Sadak Katherine , Halberstam Alexandra A. , Brown Jason R. , Perry Curtis J. , Bunn Azia , Braun David A. , Adeniran Adebowale , Lee Sangwon , Wang Andrew , Perry Rachel J. 
Published: April 2023

AbstractMetabolic homeostasis is one of the most exquisitely tuned systems in mammalian physiology. Metabolic homeostasis requires multiple redundant systems to cooperate to maintain blood glucose concentrations in a narrow range, despite a multitude of physiological and pathophysiological pressures. Cancer is one of the canonical pathophysiological settings in which metabolism plays a key role. In this study, we utilized REnal Gluconeogenesis Analytical Leads (REGAL), a liquid chromatography-mass spectrometry/mass spectrometry-based stable isotope tracer method that we developed to show that in conditions of metabolic stress, the fasting hepatokine fibroblast growth factor-21 (FGF-21)1, 2coordinates a liver-brain-kidney axis to promote renal gluconeogenesis. FGF-21 promotes renal gluconeogenesis by enhancing β2 adrenergic receptor (Adrb2)-driven, adipose triglyceride lipase (ATGL)-mediated intrarenal lipolysis. Further, we show that this liver-brain-kidney axis promotes gluconeogenesis in the renal parenchyma in mice and humans with renal cell carcinoma (RCC). This increased gluconeogenesis is, in turn, associated with accelerated RCC progression. We identify Adrb2 blockade as a new class of therapy for RCC in mice, with confirmatory data in human patients. In summary, these data reveal a new metabolic function of FGF-21 in driving renal gluconeogenesis, and demonstrate that inhibition of renal gluconeogenesis by FGF-21 antagonism deserves attention as a new therapeutic approach to RCC.
Evolution and Genetic Characterization of Seoul Virus in Wild RatsRattus Norvegicusfrom an urban park in Lyon, France 2020-2022
Authors: Alburkat Hussein , Smura Teemu , Bouilloud Marie , Pradel Julien , Anfray Gwendoline , Berthier Karine , Dutra Lara , Loiseau Anne , Niamsap Thanakorn , Olander Viktor , Sepulveda Diana , Venkat Vinaya , Charbonnel Nathalie , Castel Guillaume , Sironen Tarja 
Published: April 2023

AbstractSeoul virus (SEOV) is an orthohantavirus primarily carried by rats that can cause hemorrhagic fever with renal syndrome (HFRS) in humans. Nowaday s, its incidence is likely underestimated. We developed a comprehensive serological and molecular characterization of SEOV inRattus norvegicuspopulation from a popular urban park within a large city (‘Park of La Tête d’Or’, Lyon, France) between 2020 and 2022. We confirmed the circulation of SEOV in rats from the park (seroprevalence 17.2%). The SEOV strains detected showed high genetic similar ity with the strain previously described in 2013 in this area. We found low structuring of wild rat populations within Lyon city. This study confirms the circulation of SEOV in Lyon city, in a park where opportunities for SEOV transmission to humans are numerous. Given the high gene flow between rat populations in the park and the rest of the city, we recommend conducting city-wide SEOV surveillance.
Non-specific recognition of histone modifications by H3K9bhb antibody
Authors: Tsusaka Takeshi , Oses-Prieto Juan A. , Lee Christina , DeFelice Brian C. , Burlingame Alma L. , Goldberg Emily 
Published: April 2023

SummaryKetone bodies are short chain fatty acids produced in the liver during periods of limited glucose availability that provide an alternative source of energy for the brain, heart, and skeletal muscle. Beyond this classical metabolic role, β-hydroxybutyrate (BHB), is gaining recognition as a pleiotropic signaling molecule. Lysine β-hydroxybutyrylation (Kbhb) is a newly discovered post-translational modification in which BHB is covalently attached to lysine ε-amino groups. This novel protein adduct is metabolically sensitive, dependent on BHB concentration, and found on proteins in multiple intracellular compartments, including the mitochondria and nucleus. Therefore, Kbhb is hypothesized to be an important component of ketone body-regulated physiology. Kbhb on histones is proposed to be an epigenetic regulator, which links metabolic alterations to gene expression. However, we found that the widely used antibody against the β-hydroxybutyrylated lysine 9 on histone H3 (H3K9bhb) also recognizes other modification(s), which are increased by deacetylation inhibition and include likely acetylations. Therefore, caution must be used when interpreting gene regulation data acquired with the H3K9bhb antibody.
Nothing for us, without us: a review of the clinical literature and discursive evidence of interpersonal trauma in autistic women
Authors: Schnabel Alexandra , Bastow Clem 
Published: April 2023

PurposeFrom the authors’ personal and professional experiences, they have observed that autistic women are uniquely at risk of interpersonal trauma. Given the tendency for autistic women to be overlooked in research and practice, this study aims to rectify this by exploring the relevant literature and including the voices of autistic women throughout this paper.Design/methodology/approachThis study completed a literature review of quantitative and qualitative data relating to exposure to interpersonal trauma in autistic women. This study also reviewed relevant discursive evidence available on in memoirs and reports. This study also included dialogue between us as authors from an auto/“Autie”-ethnographic position.FindingsBoth clinical literature and discursive evidence support the idea that autistic women are uniquely at risk of interpersonal trauma, in particular, sexual victimisation. Explanatory factors are considered. Studies exploring rates of post-traumatic stress disorder (PTSD) were less consistent. Further evidence is required to better understand how autistic women experience and express PTSD and to inform assessment and treatment modifications.Originality/valueTo the best of the authors’ knowledge, this is the first paper to integrate clinical literature and discursive evidence on the topic of interpersonal trauma in autistic women. It provides useful insights into the experiences of autistic women in this space, directions for urgently needed future research and modifications to clinical practice.
Hearing and being heard: LGBTQIA+ cross-disciplinary collection development
Authors: Pavenick Alexis , Martinez George 
Published: April 2023

Purpose
The purpose of this paper is to share how informal cross-disciplinary outreach methods can increase the development, awareness, investment and circulation of lesbian, gay, bisexual, transgender, queer, intersex, asexual (LGBTQIA+) collection in an academic library. The authors believe the methods shown here may be used to develop any collection, as well as increase awareness and use of a collection.

Design/methodology/approach
Through five different low-stakes outreach strategies, the authors connected directly with campus faculty and students across disciplines to ask for suggested items to develop an endowed LGBTQIA+ collection. Outreach was performed via email to faculty and student clubs, and by attending campus facilities, events and committees. Assessment reviewed the collection’s item count and circulation reports before and after outreach.

Findings
Purchasing items to develop a collection does not always need to be the result of one librarian’s research. Engaging the campus community in the expansion of the endowed LGBTQIA+ collection resulted in substantial growth of items in the collection, as well as substantial growth in the collection’s circulation. Involving faculty and students from multiple disciplines in the suggestion process is one way to build and ensure a collection is relevant to a variety of interests, with an added result of increased circulation.

Originality/value
This approach is a unique example of how to use low-stakes engagement to discover items to purchase for a large endowment while increasing interest and circulation of the collection. The case study also explores how to embark on collection development in ways that effectively and sustainably reach beyond one academic discipline. Yet, the authors believe this study’s examples could also be used successfully within a single discipline.
Corporate strategy, political contributions and corporate risk-taking
Authors: Halari Anwar , Ahmad Sardar , Ullah Subhan , Amankwah-Amoah Joseph 
Published: April 2023

Purpose
Despite the importance and prevalence of corporate political activities in modern organizations, there remains limited insight on the potential relationship between political contributions and companies’ risk-taking activities. This study aims to examine the relationship between monetary political contributions of firms and corporate risk-taking activities in the context of unstable political and economic environments.

Design/methodology/approach
The authors use a two-step system GMM estimation to investigate the subject using a cross-country sample of 307 firms from 22 countries covered over 2002–2017. In line with previous studies, the authors control for various corporate governance mechanisms, firm-level factors and country-level characteristics.

Findings
The findings demonstrate that firms that make monetary political contributions exhibit lower levels of risk as measured by different proxies for risks, namely, systematic, idiosyncratic and total risk.

Practical implications
The results suggest that political contributions can be a useful mechanism to mitigate risk exposure. Also, the use of different risk measures and other factors for robustness fosters a better understanding of political connectedness in a more contextualized and dynamic manner.

Originality/value
This study seeks to contribute to the debate surrounding corporate strategy, political connectedness and corporate risk-taking by using actual monetary political contributions as an explicit measure of political connection. This study furthers scholarly understanding on the dynamics of corporate political activities using political contributions in monetary terms as a measure of political connectedness and its impact on risk-taking. Furthermore, the authors explore this topic using insights from nonmarket strategy literature and studies on political contributions.
How relatedness-supportive CSR enhances brand happiness: a relationship motivation theory perspective
Authors: Gilal Faheem Gul , Gilal Naeem Gul , Gilal Rukhsana Gul , Yang Zhiyong 
Published: April 2023

PurposeThe goal of this paper is twofold: (1) to investigate how relatedness-supportive corporate social responsibility (CSR) initiatives influence brand happiness among retail bank customers through a mediating mechanism of customer participation in brand CSR movements; and (2) to analyze how relatedness-supportive CSR initiatives’ effect may be moderated by cause choice and customer-brand goal congruence.Design/methodology/approachData were collected from 379 retail bank customers via a paper-and-pencil survey. The hypothesized moderated-mediation effects were tested using Hayes’ (2013) PROCESS (Model 3, Model 4 and Model 7).FindingsResults show that relatedness-supportive CSR initiatives increase brand happiness among retail bank customers through increasing their participation in brand CSR movements. Furthermore, the use of customer determination in the choice of cause enhances the positive effect of relatedness-supportive CSR initiatives on customer participation in brand CSR movements. Similarly, when customers choose the cause and the customer-brand goal is congruent, the effect of relatedness-supportive CSR initiatives on brand happiness is stronger than when the customer-brand goal is incongruent and cause choice is not aligned.Originality/valueThis research is grounded on the relationship motivation theory (RMT), basic psychological needs theory and self-congruity theory to unpack the relationship between relatedness-supportive CSR programs on brand happiness. Integrating three research streams (i.e. CSR, brand management and retail banking), this study proposes customer participation in brand CSR movements as a novel mechanism and sheds light on how relatedness-supportive CSR interplays with cause choice/customer-brand goal congruence to affect brand happiness among retail bank customers in emerging markets.
Dealing with complexity – the contribution of problem structuring methods to management science
Authors: Kogetsidis Harry 
Published: April 2023

Purpose
The purpose of this paper is to examine the contribution that problem structuring methods – a branch of the decision support discipline of operational research – have made in helping managers deal with situations of high complexity. The paper reviews the limitations of traditional operational research and argues that problem structuring methods have expanded the entire discipline and significantly contributed to its holistic nature and problem-solving orientation.

Design/methodology/approach
The paper provides a critical discussion of the limitations of the traditional operational research approach and examines how the development and successful application of problem structuring methods have opened up a new paradigm of analysis in management science.

Findings
In theoretical terms, problem structuring methods have moved the discipline of operational research away from its positivistic epistemology and towards interpretivism and the acceptance of a subjective social reality. In practical terms, they offer managers a broad range of appropriate analytical tools which provide transparency and offer the opportunity to those affected by the problem situation to be actively involved in the entire modelling process within a facilitated environment.

Originality/value
The paper offers a critical discussion of the contribution that problem structuring methods have made while also identifying the challenges they face as they try to achieve higher levels of recognition and acceptance in management science.
A buzzword, a phase or the next chapter for the Internet? The status and possibilities of the metaverse for tourism
Authors: Wei Wei 
Published: April 2023

PurposeGrowing recognition of the metaverse has implied its far-reaching impacts on the tourism and hospitality industry. This paper sets out to detail the status of metaverse-related research in tourism and hospitality, propose intriguing directions for future studies and highlight multiple areas that call for immediate attention from practitioners in navigating the metaverse phenomenon.Design/methodology/approachThis viewpoint paper referenced the extant academic discussion on the metaverse, based on which timely suggestions for academia and practices are proposed.FindingsThis viewpoint paper presents an account of the metaverse and discusses the status of metaverse-related research in hospitality and tourism. It then proposes intriguing avenues for future research around the topics of marketing, reconceptualizing service quality, attitude and behaviors, electronic customer-to-customer interactions, transformative impacts on the society well-being and research methodology. Multiple areas that call for immediate attention from practitioners in navigating the metaverse phenomenon are also highlighted. Both scholars and industry organizations are called upon to assume some responsibility for mapping out protocols to guide the appropriate development, use and governance of metaverse worlds. Governments and policymakers are further encouraged to consider the ramifications of metaverse development for individuals and society and to devise proactive mitigation strategies.Practical implicationsThis viewpoint paper proposes several directions for future business practices in the areas of co-creation, experiential consumption, and emerging critical issues in healthcare, human resources, and social media services. It expects to inspire more discussion about the potential impacts of metaverse on the wider society. Its practical significance will further expand the theoretical foundation of the metaverse research and makes this viewpoint paper an intriguing prospect.Originality/valueThe nascent stage of academic discussion intended to guide the development of metaverse is noteworthy, which forms a notable contrast with the growing recognition of its potential of co-creating transformational experiences in hospitality and tourism. This viewpoint paper joins the current academic conversations acknowledging this phenomenon in hospitality and tourism. Provided the notable topicality and empirical relevance, the expanded scope and rich content the present viewpoint paper provides for metaverse will offer a fruitful ground for future research to tap further into currently underrepresented areas.
Strategic horizon of market success: comparing alternative “strategic landscapes” of the new product development process
Authors: Sameti Ardalan 
Published: April 2023

PurposeThe success rate of new products is stubbornly low. This paper aims to explore the differences in how product designers and product managers approach the new product development task by comparing their perspectives on the process.Design/methodology/approachThis study conducted a worldwide survey of professional product designers and managers and compared their perspectives.FindingsManagers struggle to understand the problem to be solved until they see the solution in the form of an outstanding product design. Designers struggle to develop new products until they have a specific and insightful understanding of the problem that needs to be solved.Practical implicationsDesigners’ and managers’ ways of thinking are different, and effective collaboration depends on them being cognizant of each other’s ways of thinking; the success of their work is highly interdependent.Originality/valueTo the best of the authors’ knowledge, this study is the first study that simultaneously investigates both product designers and managers to reveal the paradoxical dynamics between their perspectives.
Auditors’ legal liability and client firms’ comparability: evidence from China
Authors: Liu Yanghui , Chen Jeff Zeyun , Chi Wuchun , Long Xiaohai 
Published: April 2023

Purpose
This paper aims to investigate the relation between audit firms’ switch to limited liability partnership (LLP) from limited liability company (LLC) and client firms’ earnings comparability. If LLP auditors, who have a higher liability exposure than LLC auditors, are more consistent in implementing generally accepted accounting principles and executing firm-wide audit methodologies, client firms’ earnings comparability will increase.

Design/methodology/approach
Using data from China, the authors examine whether client firm-pairs of LLP auditors have higher earnings comparability than client firm-pairs of LLC auditors. The authors also perform cross-sectional tests to shed light on the mechanisms through which auditors’ litigation exposure affects client firms’ comparability.

Findings
The authors find that firm-pairs in which both firms are audited by LLP auditors exhibit higher earnings comparability than other firm-pairs. This result is stronger when client firms are audited by the same auditor, when client firms are audited by the top 10 auditors and when the auditors are less dependent on the client firms. The authors also document that firm-pairs in which both firms are audited by LLP auditors have lower average analyst earnings forecast error and forecast dispersion.

Originality/value
To the best of the author’s knowledge, this study is the first to examine the relation between auditor’s litigation exposure and client firms’ earnings comparability. It also extends the literature on audit firm organizational form and audit quality.
Reflecting on intellectual capital measurement and management in European universities
Authors: Secundo Giustina , Lombardi Rosa , Dumay Johannes , Guthrie A.M. James 
Published: April 2023

Purpose
This paper aims to critically review intellectual capital (IC) accounting research and practices in European public universities, specifically in Spain, Austria and Italy. These three countries represent the majority of IC accounting research related to universities.

Design/methodology/approach
This study critically reviews a selection of university-based IC accounting research, applying Alvesson and Deetz’s (2000) critical perspectives of insight, critique and transformative redefinition.

Findings
The analysis reveals that European public universities follow the Humboldtian model of higher education, integrating a third mission to society into their traditional roles as teaching and research institutions. This study explored how the emergence of a third mission for the university was conceptualised. This study also provided insights, critique and a transformative redefinition to advance IC as a strategic resource in European public universities.

Originality/value
The findings provide academics and policymakers with insights, critique and a transformative redefinition of IC as a strategic resource for European public universities to meet future challenges in an ever-changing world.
Surviving the unprecedented: family firms under COVID-19
Authors: Bressan Alessandro , Duarte Alonso Abel , Vu Oanh Thi Kim , Borer Daniel 
Published: April 2023

Purpose
The purpose of this study is to examine factors contributing to family firms’ survival in the ongoing COVID-19 crisis; in this endeavour, the study espouses the underpinnings of social exchange theory and entrepreneurial resilience.

Design/methodology/approach
The views of 128 Italian family micro and small-sized firm owners/managers operating in different industries were gathered through an online questionnaire.

Findings
The analysis uncovers 12 fundamental factors contributing to firms’ survival; these are encapsulated in three dimensions and presented in two theoretical frameworks. The “beneficiary” dimension stresses the support from various internal and external stakeholders, while the “benefactor” dimension illustrates the commitment to extend the family tradition and be responsive to stakeholders. Finally, the “immersion/embeddedness” dimension denotes firms’ entrepreneurial behaviour, agility, decision-making and drive.

Originality/value
Firstly, and from a practitioner perspective, this study addresses recognised knowledge and research gaps in contemporary family business research, including how family firms are confronting the current unprecedented crisis. This response to current extant gaps provides first-hand empirical findings that could be primarily considered by industry stakeholders. Secondly, and from a theoretical angle, the aforementioned dimensions revealed through the analysis, coupled with the development of a theoretical framework, contribute to conceptual rigour and, therefore, a deeper understanding of family firms’ journey through an unprecedented event.