bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative clinical and placental pathologic characteristics in pregnancies with and without SARS-CoV-2 infection
Authors: Turdybekova Yasminur Gabdulhakovna , Kopobayeva Irina L. , Kamyshanskiy Yevgeniy K. , Turmukhambetova Anar A. 
Published: July 2023

Abstract

Objectives
To compare the clinical and morphological characteristics of the “mother-placenta-fetus” system in high risk pregnant women of three groups: no SARS-CoV-2 infection, mild SARS-CoV-2 infection, and severe SARS-CoV-2 infection.

Methods
A case-control study was performed for all deliveries, at 28 weeks’ gestation or greater, who had standard indications for placental pathologic examination. Three groups were formed: (1) control group (no SARS-CoV-2 infection), (2) mild SARS-CoV-2 infection, (3) severe SARS-CoV-2 infection. High-risk pregnancies were registered in all cases in the study groups. The examination of the placenta and the selection of fragments of placental tissue were carried out in accordance with the consensus recommendations of the Amsterdam Placental Workshop Group. The sections were subjected to standard processing and stained with hematoxylin and eosin according to the standard protocol. All cases were reviewed by two pathologists, which did not know any information on pregnancy outcome and clinical data. Statistical analysis was performed using SPSS, p<0.05 was considered statistically significant.

Results
Women with severe SARS-CoV-2 infection had an increased rate of multimorbidity including diabetes, chronic hypertension and obesity (p<0.01) compared with the other groups. Placentas at severe COVID-19 course were damaged by both chronic and acute injuries, in comparison to the mild and control groups (p<0.001). Also an important finding in severe COVID-19 was diffuse necrosis of the villous trophoblast – homogenization, diffuse circular eosinophilic masses surrounding the chorionic villi.

Conclusions
Women with multimorbidity are an “at-risk” subgroup for severe SARS-CoV-2 infection and greater likelihood of both placental damage and perinatal hypoxic-ischemic events. These results suggest that patient education, SARS-CoV-2 disease monitoring and preventive measures would be of benefit to this group.
From verb to epistemic marker: bini in Hamedanian Persian
Authors: Rasekh-Mahand Mohammad , Sabouri Fariba 
Published: July 2023

Abstract
This paper provides data from a regional dialect of Persian, Hamedanian Persian, where a verb is grammaticalized to be used as epistemic modality marker, frequently used in interrogatives. The verb didan, objectively means ‘to see’, but subjectivized in many instances to mean ‘understand’. However, in this dialect, bini, originally the subjunctive second person singular form of the verb didan ‘to see’, is used as epistemic marker. It is used in content and polar questions, where uncertainty is a common feature. Our fieldwork data show that the verb didan is used rarely to mean ‘to see’ and it extended to mark epistemic modality, used as probability marker. This modal marker is only used in questions, which share the stance of uncertainty with epistemic markers. The various features of this grammaticalization path are discussed and an explanation based on egophoricity is provided.
The role of the communicated treatment rationale on treatment outcome: study protocol for a randomized controlled trial.
Authors: Henrich Liv , Wilhelm Marcel , Lange Philipp , Rief Winfried 
Published: July 2023

Abstract

Background
Placebo effects are a well-established phenomenon in the treatment of depression. However, the mechanism underlying these effects are not fully understood. Treatment expectations are considered one explanation for why placebos work. Treatment expectations are likely to be affected by clinician-patient interactions. This study aims to investigate the role of the communicated treatment rationale in modulating treatment expectations and its effects on the treatment outcomes of a pharmacological and a psychological active placebo intervention for depression. In this study, treatment expectations are modulated by presenting illness models that are either congruent or incongruent with the treatment intervention that follows.
Methods
This 2x2 randomized controlled trial will involve patients with major depression. Participants will either receive a biological or a psychological illness model from a clinician. Following this they are randomly assigned to receive either a pharmacological or a psychological active placebo intervention. The illness model and the treatment are either congruent or incongruent with each other, resulting in four groups. In addition, a natural course control group will be included.
Discussion
This study will provide insights into the mechanism of expectation modulation in active placebo treatments for major depression. The results may provide insights for clinicians to improve their communication with patients by focusing on treatment expectations. By identifying the factors that contribute to placebo effects, this study has the potential to improve the effectiveness of existing depression treatments and reduce the burden of this highly prevalent mental health condition.
Trial registration
This trial has been registered prospectively at clinicaltrials.gov under the identifier: NCT04719663.
Knowledge, Attitudes and Compliance to Infection Control Guidelines in Private Dental Clinics in Israel, a Cross Sectional Survey
Authors: Khubazan Alaa , Nutman Amir 
Published: July 2023

Abstract
Background
Little is known on adherence to infection control in Israeli private dental clinics. This study aimed to investigate the Knowledge, Attitudes, and Adherence to infection prevention and control (IPC) guidelines in private dental clinics in Israel.
Methods
A cross-sectional survey among dentists working in private dental clinics in Israel. Knowledge, Attitudes and Adherence to IPC guidelines were assessed using an online questionnaire sent to the study participants via e-mail, Facebook and other social media platforms. The questionnaire included 49 multiple-choice questions on demographics, Knowledge, Attitudes and Adherence to IPC guidelines. Statistical analysis included descriptive statistics; a composite score for each domain (Knowledge, Attitude and Adherence) was calculated (percentage of correct answers in Knowledge domain, percentage of positive answers ("agree" or "strongly agree") in Attitude domain, and percentage of high adherence ("all the time", "frequently" or "yes") in the Adherence domain). The association between Knowledge and Attitude scores, and Adherence with IPC practices was assessed by chi-square test. Hierarchical multivariable logistic regression was used to adjust for demographic variables.
Results
The questionnaire was sent to 270 dentists and 100 participated in the study (overall response rate of 37%). The majority of participants (63%) had moderate scores in the knowledge domain (scores between 50–70%), 47% had a positive score in the Attitude domain (scores above 80%), and only 41% had a high score in the Adherence to IPC domain (scores above 80%). Compliance with IPC score was highest among participants with a high knowledge score (70.0%), compared to moderate (33.3%) and low (35.3%) scores; and among participants with a positive Attitude score (51.1%), compared to neutral (39.5%) and negative (13.3%) Attitude scores. In the multivariable analysis, Knowledge and Attitude scores were independent predictors of good IPC practice (with an effect size of 0.28).
Conclusions
In this survey, compliance with IPC guidelines among dentists in private clinics in Israel was generally low. We found a positive correlation between Knowledge, Attitude and Adherence to IPC guidelines. Educational programs and courses on IPC are recommended to improve Knowledge and positive Attitudes and thus increase compliance.
The modified cross-suture technique for loop stoma reversal: A single-center randomized controlled study
Authors: Zhang Li-Xiao , Kang Jia-Qi , Ye Zhi-Bin , Zhang Li-Fei , Liang Wei 
Published: July 2023

Abstract
Objective:
To explore the application effect of modified cross-suture technique in loop stoma reversal.
Methods:
From June 2019 to December 2022, patients with loop stoma reversal were divided into observation group (35 cases) and control group (25 cases) according to the numerical random method. According to the different methods of skin suture, the observation group was treated with modified cross-suture technique, and the control group was treated with interrupted suture method. The operation time, intraoperative blood loss, postoperative out-of-bed time, postoperative exhaust time, postoperative eating time, primary healing time, incision infection rate, incision healing time after incision infection, postoperative hospital stay, postoperative early pain score, and overall patient satisfaction score were compared between the two groups.
Results:
There were no significant differences in age, gender, body mass index, American Society of Anesthesiologists, disease history, remission interval, operation time, intraoperative blood loss, and primary healing time between the two groups (P>0.05). The postoperative out-of-bed time, postoperative exhaust time, postoperative eating time, postoperative hospitalization time, hospitalization cost, postoperative early pain score, and incision infection rate in the observation group were all lower than those in the control group (P<0.05). The healing time after incision infection in the observation group was shorter than that in the control group (P<0.05). The overall satisfaction score of patients in the observation group was higher than that in the control group (P<0.05).
Conclusions:
The modified cross-suture technique is a suitable incision treatment method for loop stoma reversal.
Bio-based vanillyl alcohol epoxy thermoset with high mechanical properties and its applications for high- performance natural fiber-reinforced composites
Authors: Kumar Bijender , Adil Samia , Kim Jaehwan 
Published: July 2023

Abstract
With the massive usage of fossil-based resources and net-zero missions, developing bio-based epoxy resin and sustainable composites with excellent comprehensive properties from biomass resources as an alternative to commercial petroleum-based epoxy is still a crucial challenge. Herein, taking advantage of the mono and diepoxy cross-linking network structure, a lignin-derived novel cross-linked vanillyl alcohol epoxy (VAE) thermoset-containing mono and di (m&d) epoxy structure is prepared by the epoxidation of the vanillyl alcohol, followed by curing with hardener. The synthesized m&dVAE containing mono and di-epoxidized (m&d) aromatic rings, when cured with 4, 4´-diaminodiphenyl methane (DDM) hardener, exhibits higher record tensile strength ~ 124.0 ± 8.43 MPa and tensile modulus ~ 2.88 ± 0.35 GPa compared to a commercial petroleum-based epoxy, diglycidyl ether bisphenol A (DGEBA) thermoset. Additionally, it demonstrated higher adhesion shear strength (~ 19.16 ± 0.58 MPa) with cellulose nanofibers film than DGEBA. Further, the synthesized m&dVAE-DDM resins are used for bio-based natural fiber-reinforced composites for the first time. The green composite possesses excellent flexural strength of ~ 203.72 ± 2.08 MPa and stiffness of ~ 11.58 ± 0.38 GPa than the petroleum-based thermoset composite. Moreover, the green composite showed good hydrophobicity and an excellent heat-resistant index of 144.4°C. The m&dVAE resin can be an alternative to petroleum-based resins, and its environment-friendly green composite could be a promising candidate to replace synthetic materials for high-performance structural applications.
Clinical, analytical, imaging and ECG differences in adult patients infected by Borrelia burgdorferi and doubly-infected by Babesia divergens-Borrelia burgdorferi
Authors: Folgueras María , González Luis Miguel , Collazos Julio , Rodríguez-Pérez Mercedes , Pérez-Is Laura , Diaz-Arias Javier , Meana Maria , Revuelta Belen , Montero Estrella , Asensi Victor 
Published: July 2023

Abstract
Differences between double infection by Borrelia burgdorferi-Babesia divergens and Borrelia burgdorferi monoinfection in adult patients have not been reported so far. Both zoonosis, endemic in Northwestern Spain, are transmitted by Ixodes tick bites. Clinical, analytical and other tests (imaging, ECG) characteristics of 120 adult patients with B.burgdorferi infection, of which 47 (39.2%) had B.burgdorferi-B.divergens double infection, diagnosed between 2014–2017, were retrospectively compared. Cardiorespiratory symptoms were reported in 9/47 (19.2%) patients with B.burgdorferi-B.divergens double infection compared to 4/73 (5.5%) patients with B.burgdorferi monoinfection (P = 0.02). Dyspnea was recorded in 4/47 (8.5%) doubly infected compared to 1/73 (1.4%) monoinfected patients (P = 0.07). In addition ECG atrioventricular (AV) block was detected in 5/47 (15.6%) doubly infected compared to 1/73 (2.6%) monoinfected individuals (P = 0.09). No other clinical, laboratory or other tests differences were observed between doubly infected and monoinfected patients. We conclude that doubly infected had more frequently cardiorespiratory symptoms, mostly dyspnea, compared to monoinfected individuals. These symptoms were unrelated to anemia. ECG AV block perhaps induced by summative myocardial damage due to both infections might play some role in the cardiorespiratory dysfunction.
Is Having Your Cell Phone the Key to Happiness, or Does It Really Matter?: Evidence From a Randomized Double-blind Study
Authors: McElroy Todd , Young William 
Published: July 2023

Abstract
Background
Affect can influence people's perceptions, decisions, and the way they make sense of an experience. Some studies show that having one's cell phone removed will lead to negative emotional reactions, while others have found no significant impact on how we feel. In this paper we investigate the impact of cell phone possession and removal on participant’s affective state.
Methods
We use a randomized double-blind procedure to examine whether cell phone removal enhances negativity, promotes positivity, or is emotionally inconsequential. We measure affect using a PANAS self-report scale as well as a less transparent temporal-estimation procedure.
Results
Our findings suggest that cell phone possession or removal has no influence on a person’s affective state.
Conclusions
Measured through both the PANAS self-report scale and an indirect temporal estimation task, affect remained consistent regardless of cell phone possession. These results suggest that cell phones may not carry the emotional weight often attributed to them. This finding challenges a common theme revolving around the negative emotional impact of cell phones and technology. Consequently, these findings may have important implications for restricting cell phone use in today’s world and the generally perceived notion that cell phones are having a negative effect on people’s emotions.
Stability Control Analysis of a Dung Beetle Optimizer-Based PI λ D μ Controller for a Multisource Interlinked Power Grid
Authors: Boopathi D , Jagatheesan K , Khamies Mohamed , Kamel Salah 
Published: July 2023

Abstract
This paper presents a novel approach to enhance the frequency stability of an interlinked power system considering the integration of renewable energy sources and energy storage systems. The proposed method utilizes an optimal fractional Proportional-Integral-Derivative (PID) controller, with its parameters determined by the Dung Beetle Optimizer (DBO). The interlinked power system consists of two areas: Area 1 incorporates Photovoltaic (PV) systems with energy storage units (ESUs), while Area 2 comprises thermal, hydro, nuclear, and ESUs (Hydro Aqua Electrolyser (HAE) and Fuel Cell (FC)). The effectiveness of the proposed controller is validated through a comparison of its performance with other optimization techniques, such as the Ant Lion Optimizer (ALO) and Particle Swarm Optimization (PSO). The comparative analysis demonstrates the superior performance of the DBO, as it exhibits a 25% and 4% improvement in settling time over PSO and ALO, respectively. Overall, the proposed controller proves to be highly capable of enhancing system stability during scenarios involving high renewables penetration and abnormal cases.
Modeling Online Customer Purchase Intention Behavior Applying Different Feature Engineering and Classification Techniques
Authors: Satu Md. Shahriare , Islam Syed Faridul 
Published: July 2023

Abstract
Online shopping, known as e-shopping, has added a new dimension to the business sector. The concept of consumption among customers has changed significantly as a result of the quick growth of computer technology and e-commerce. The purpose of this work is to investigate the outcomes of different machine learning techniques and predict online shoppers’ purchasing intentions from e-commerce sites. In this study, we collected a dataset of online shoppers' purchasing intentions from the University of California Irvine (UCI) data repository. Different feature transformation techniques were employed in the primary dataset and generated transformed datasets. Besides, transformed datasets were balanced and detected outliers from them. Then, we applied different feature selection methods into primary and transformed balanced datasets and again generated several feature subsets. Further, different classifiers were implemented into all of these generated datasets and obtained different outcomes for them. In this work, Random Forest performed the best accuracy of 92.39% for Z-Score and Gain Ratio Attribute Evaluation transformed dataset. In addition, this classifier also provided the highest AUROC of 0.974 for Square Root and Gain Ratio Attribute Evaluation dataset. Therefore, Random Forest is a more stable classifier to predict customer purchase intention than other models.
Orthopantomography Versus Cone Beam Computed Tomography for the
Assessment of the Proximity of Posterior Maxillary Apexes with the Maxillary
Sinus: A Cross-sectional Study
Authors: Rodríguez Macarena , Marshall Maureen , Godoy Constanza , Richa Roxana , Niklander Sven Eric 
Published: July 2023

Background:
The lack of knowledge of the relation of the maxillary sinus with the apexes of maxillary posterior teeth can lead to important complications during common dental procedures. This can be avoided using different imaging techniques, such as orthopantomography (OPG) and cone beam computed tomography (CBCT). The present study aims to compare the performance of OPG with CBCT in measuring the vertical distance of the apexes of posterior-superior teeth to the maxillary sinus.

Methods::
This study corresponded to a cross-sectional study. OPGs and CBCT scans were obtained from the same individuals, and the qualitative and quantitative vertical distance of the apexes in relation to the maxillary sinus was categorized and measured in mm.

Results:
A total of 28 pairs of OPGs and CBCT scans from the same patients were obtained. About 381 roots were analysed, which included 89 upper first premolars, 51 upper second premolars, 115 upper first molars, and 126 upper second molars. Projection/protrusion was observed with more frequency in molars, specially 1º molars in both OPG (n= 75, 65.2%) and CBCT (n= 31, 27%); however, 106 more cases (27.9%) were classified as projected in the OPG compared to CBCT (p < 0.05). When comparing the performance of the OPG and CBTC for analysing all roots qualitatively, there was a 57.8% agreement between both techniques. This difference was statistically significant (p <0.0001). Statistically significant differences were also observed when comparing the millimetric differences.

Conclusion:
This study showed that OPG is not an accurate technique to observe the relationship between the maxillary sinus and the apexes of the upper posterior teeth. In those cases where precision is required when performing dental procedures in this area, CBCT should be used. When not available, the clinicians should be aware of the limitations of the OPG and add other complementary techniques.
The Mediating Role of miR-451/ETV4/MMP13 Signaling Axis on Epithelialmesenchymal
Transition in Promoting Non-small Cell Lung Cancer Progression
Authors: Qian Xue-Jiao , Wang Jing-Wen , Liu Jiang-Bo , Yu Xi 
Published: July 2023

Background:
Lung cancer is a leading cause of cancer mortality. It is one of the most abundant cancer types clinically, with 2 million new cases diagnosed yearly.

Aims:
Using clinically collected non-small cell lung cancer (NSCLC) samples, we sought to hypothesize an innovative intact signaling cascade for the disorder.

Methods:
We dissected snap-frozen NSCLC tissues along with sibling-paired nearby non-tumorous tissues from 108 NSCLC patients. We measured the expression levels of miR-451/ETV4/MMP13 using qRT-PCR and did a thorough investigation of the molecular mechanism for the signaling axis in NSCLC cell line A549. We also studied the epithelial-mesenchymal transition (EMT) process.

Results:
The activity of miR-451 was significantly decreased in NSCLC tissues, while the expression levels of ETV4 and MMP13 were remarkably increased. At the same time, miR-451 levels maintained a declining trend across TNM stage I–III. Inversely, ETV4 and MMP13 increased as the TNM stage increased. The miR-451/ETV4/MMP13 signaling axis was closely associated with prognosis in NSCLC patients. Based on in vitro experiments, ETV4 was a direct targeting factor for miRNA-451. Meanwhile, ETV4 promoted the tumor properties of NSCLC cells by directly activating MMP13. Silencing MMP13 blocked the EMT progress of NSCLC cells.

Conclusion:
Overall, we hypothesized an impeccable signaling pathway for NSCLC from a new aspect, and this can offer alternative insights for a better understanding of the disorder.
An Assessment of Meal Anticipation for Improving Fully Automated Insulin Delivery in Adults with Type 1 Diabetes
Authors: Garcia-Tirado Jose , Colmegna Patricio , Villard Orianne , L. Diaz Jenny , Esquivel-Zuniga Rebeca , L. K. Koravi Chaitanya , L. Barnett Charlotte , C. Oliveri Mary , Fuller Morgan , A. Brown Sue , D. DeBoe Mark 
Published: July 2023

<p> </p>
<p><strong>Objective: </strong>Meals are a consistent challenge to glycemic control in type 1 diabetes (T1D). Our objective was to assess the glycemic impact of meal anticipation within a fully automated insulin delivery (AID) system among adults with T1D.</p>
<p><strong>Research Design and Methods:</strong> We report the results of a randomized-crossover clinical trial comparing three modalities of AID systems: hybrid closed-loop (HCL), full closed-loop (FCL), and full closed-loop with meal anticipation (FCL+). Modalities were tested during three supervised 24h admissions, where breakfast, lunch, and dinner were consumed per participant’s home schedule, at a fixed time, and 1.5h delayed, respectively. Primary outcome was the percent time-in-range 70-180mg/dL (TIR) during the breakfast post-prandial period for FCL+ vs. FCL. </p>
<p><strong>Results: </strong>Thirty-five adults with T1D (age 44.5±15.4y; HbA1c 6.7±0.9%; 23F/12M) were randomized. TIR for the 5h-period following breakfast was 75±23%, 58±21%, and 63±19%, for HCL, FCL, and FCL+ respectively, with no significant difference between FCL+ and FCL. For the 2h before dinner TBR was similar for FCL and FCL+. For the 5h-period following dinner TIR was similar for FCL+ and FCL (71±34% vs. 72±29%; p=1.0) while TBR was reduced in FCL+ (median: 0 [0-0]% vs. 0 [0-0.8]%;p=0.03). Overall, 24-h control for HCL, FCL and FCL+ was 86±10%, 77±11%, and 77±12%, respectively.</p>
<p><strong>Conclusions: </strong>While postprandial control remained optimal with hybrid AID, both fully AID solutions offered overall TIR above 70% with similar or lower exposure to hypoglycemia. Anticipation did not significantly improve postprandial control in AID systems but also did not increase hypoglycemic risk when meals were delayed.</p>