bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contrast induced nephropathy in older Vietnamese patients undergoing coronary angiography and intervention
Authors: Nguyen T , Quang N T , Liu W , Ngo T K T , Nguyen T V 
Published: January 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
The prevalence of coronary heart disease increases with age and older people accounted for a large proportion of patients presenting with coronary heart disease. Advancement in percutaneous coronary intervention (PCI) has contributed to reduced mortality in patients with coronary artery disease. However, coronary angiography and percutaneous intervention have also increased the risk of developing contrast induced nephropathy (CIN), especially in older patients. More than ten risk assessment tools have been developed to predict CIN. Among these, the Mehran risk score has been the most commonly used in Vietnam. In recent years, new simple risk prediction models have been proposed, including the contrast volume-to-glomerular ﬁltration rate ratio (CV/GFR ratio). The CV/GFR ratio is calculated as the ratio of contrast medium quantity to glomerular ﬁltration rate.

Purpose
The aim of this study was to (1) examine the incidence of CIN in a cohort of older patients undergoing coronary angiography and/or PCI at a tertiary hospital in Vietnam, (2) compare the validity of the CV/GFR ratio and the Mehran score in predicting CIN, and (3) to identify optimal cut-off points of these scales by which can help identify older patients with high risk of developing CIN in this population.

Methods
A prospective observational study was conducted in patients aged ≥ 60 years at a tertiary hospital in Vietnam from September 2019 to May 2020. CIN was defined as 25% increase in serum creatinine from baseline or 0.5mg/dL absolute increase in serum creatinine occurring within 48 hours post IV contrast administration. The CV/GFR ratio and the Mehran score were applied for predicting risk of CIN. Previous studies suggest Mehran score &gt;5 or CV/GFR ratio &gt;3.7 as a predictor of an early abnormal increase in serum creatinine after PCI. Receiver Operator Characteristic (ROC) was applied to evaluate area under the curve (AUC) of the CV/GFR ratio and Mehran score in predicting CIN, and the sensitivity, specificity for common cut-off points that were suggested in previous studies.

Results
A total of 170 participants were included in this study. They had a mean age of 70 years, 33.1% were women. The incidence of CIN was 9.4%. Participants with CIN had higher prevalence of chronic kidney disease, heart failure and anaemia at admission. The AUC of the CV/GFR ratio against CIN was 0.79 (95%CI 0.65-0.92), and of the Mehran score against CIN was 0.65 (95%CI 0.51-0.82) (Figure 1). The sensitivity and specificity for common cut-off points of the CV/GFR ratio and Mehran score are presented in Figure 2.

Conclusions
Our study found that CIN was common in older patients after PCI. Both CV/GFR ratio and Mehran score had good diagnostic value for predicting CIN in the study participants.
Effect of therapeutic dose anticoagulation vs prophylactic dose anticoagulation in reducing venous thromboembolism, arterial thrombosis or death events among hospitalized non-critically ill COVID19 pt
Authors: Egnora L J B , Inso C A V 
Published: January 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Title
The Effect of Therapeutic Dose Anticoagulation Versus Prophylactic Dose Anticoagulation in Reducing Venous Thromboembolism (VTE), Arterial Thrombosis (ATE) or Death Events Among Hospitalized Non-critically Ill COVID-19 Patients: A Meta-analysis.

Background
Coagulopathy-associated thrombotic events, leading to venous and arterial thromboembolism are highly prevalent among COVID-19 patients. While pharmacologic thromboprophylaxis are the mainstays of treatment, the consideration for an escalated therapeutic dose anticoagulation in the non-critically ill remained a highly debated issue.

Objectives
This meta-analysis sought to evaluate whether therapeutic dose anticoagulation among hospitalized non-critically ill COVID-19 patients reduce the composite primary efficacy outcome (VTE, ATE or death), and the secondary outcomes of major bleeding risk and progression to intubation and mechanical ventilation compared to prophylactic dose anticoagulation.

Methodology
After extensive search, screening based on predefined inclusion and exclusion criteria and critical appraisal by 3 independent reviewers 3 eligible open label RTCs with a total of 1492 patients were included in the study. The event rates of the primary and secondary outcomes were assessed after 21-30 days of hospitalization.

Results
The Risk Ratio for VTE, ATE and death is higher in the prophylactic dose anticoagulation (RR 1.42; 95% CI 1.08-1.86), p-value &lt;0.05) compared to therapeutic dose anticoagulation. The risk for major bleeding (RR 0.70; 95% CI 0.30-1.62, p-value &gt;0.05) and progression to intubation and mechanical ventilation (RR of 1.13; 95% CI 0.93-1.38, p-value &gt;0.05) were not significantly different between the dosing regimens.

Conclusion
Therapeutic-dose regimen among non-critically ill admitted COVID-19 patients conferred lower risk for the composite primary outcome of VTE, ATE and death with similar risk for bleeding compared to prophylactic dose regimen. Due to this outcome advantage, therapeutic-dose anticoagulation can be considered as initial regimen in the non-critically ill COVID-19 patients in the absence of contraindications.
Effects of sodium glucose cotransporter 2 inhibitors on the risk of hyperkalemia in patients on mineralocorticoid receptor antagonist: a systematic review and meta-analysis
Authors: Cordovez R A B , Rivera K A , Denila R W , Patricio M D 
Published: January 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Occurrence of hyperkalemia has been a great limitation in the full implementation of a guideline-directed medical therapy especially in patients with heart failure. Recent developments have exhibited the positive role of SGLT2 inhibitors, not only on the cardiovascular outcomes but also conferred renal protection.

Purpose
We explored the effects of SGLT2i and MRA combination on the risk of developing hyperkalemia.

Methods
Randomized controlled trials on SGLT2i versus placebo in patients already on MRA regardless of heart failure status reporting outcomes of potassium homeostasis were searched using Pubmed, CENTRAL, and ScienceDirect. Outcome of interest was the effects on the risk of hyperkalemia. Pooled hazard ratios with 95% confidence intervals were used as effect estimates using fixed-effects model.

Results
Five studies were included with a total of 11,123 patients. There was a significant reduction on the risk of hyperkalemia in the MRA with SGLT2i group (HR 0.61, 95% CI 0.50-0.75, p&lt;0.00001) compared to MRA without SGLT2i group.

Conclusion
SGLT2i provides significant risk reduction on the development of hyperkalemia in patients already on a mineralocorticoid receptor antagonist.
Implementation evaluation of mhealth interventions in the secondary prevention of coronary artery disease: a supplementary review
Authors: Lynch C , Braver J , Issaka A , De Moel-Mandel C , Zisis G , Carrington M , Oldenburg B 
Published: January 2023

Abstract

Funding Acknowledgements
Type of funding sources: Public Institution(s). Main funding source(s): La Trobe University

Introduction
mHealth technologies have evolved rapidly in recent years and are now widely implemented for the secondary prevention of coronary artery disease (CAD). While there is increasing evidence of their effectiveness, there are significant knowledge gaps concerning their reach, adoption, implementation, and maintenance.

Purpose
This study evaluates internal and external validity dimensions of mHealth-enabled cardiac disease management programs (DMPs) using elements of Glasgow’s RE-AIM (Reach-Effectiveness-Adoption-Implementation-Maintenance) Framework. It is a supplementary review to a systematic review and meta-analysis which evaluated effectiveness.

Methods
From the 27 studies reviewed for the previous systematic review on effectiveness, a citation search was performed to identify additional publications reporting on elements of reach, adoption, implementation, and maintenance. All eligible publications were independently coded by two team members using the 23-item RE-AIM extraction tool and analysed using mixed-methods to ascertain the reporting of these elements.

Results
In total, 35 publications were included in the analysis, 27 from the previous systematic review and 8 supplementary publications. The items for the Reach dimension indicated participant participation rates ranging between 18% to 67%, and used a wide range of exclusion criteria, relating to mental and cognitive impairment (37%), physical impairments (41%) and language issues (26%). Most (44%) interventions were solely home-based with nurses being the main health professionals delivering the intervention (adoption items). The implementation and maintenance items showed intervention duration of between 4-52 weeks (median 24 weeks) with intervention follow-up of between 1-48 months (median 6 months).

Conclusions
This review found great heterogeneity in the duration and follow-up of mHealth-enabled DMPs for patients with CAD, with low participation rates suggesting access barriers. Addressing RE-AIM dimensions in the evaluation of mHealth-enabled cardiac DMPs for patients with CAD is critically important for identifying factors affecting the reach, adoption, implementation, and maintenance of interventions in order to improve translation of research evidence into practice for patients, clinicians and health service organisations.
The global syndemic of metabolic diseases in the young adult population: a consortium from the Global Burden of Disease 2000-2019
Authors: Chew N , Kannan S , Chong B , Chew J , Lin C X , Goh R , Kong G , Chin Y H , Ng C H , Foo R , Chan M 
Published: January 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
A large proportion of premature deaths are related to metabolic diseases in the young adult population. We examined the global trends and mortality of metabolic diseases using estimates from the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) 2019 in individuals aged below 40 years.

Methods
From 2000-2019, global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) were described for metabolic diseases (type 2 diabetes mellitus [T2DM], hypertension, non-alcoholic fatty liver disease [NAFLD]). Global estimates were limited to mortality and DALYs for risk factors (hyperlipidemia and obesity). Subgroup analyses were performed based on sex, geographical regions and Socio-Demographic Index (SDI). Age-standardized prevalence, death, and DALYs were presented per 100,000 population with 95% uncertainty intervals (UI).

Findings
The prevalence for all metabolic diseases increased from 2000-2019, with the most pronounced increase in males and high SDI countries. In 2019, the highest age-standardised death rates were observed in hypertension (133·88 [121·25-155·73]; males, 160·13 [138·91-180·79]; females, 119·66 [102·33-136·86]), followed by obesity (62·59 [39·92-89·13]; males, 66·55 [39·76-97·21]; females, 58·14 [38·53-81·39]), hyperlipidemia (56·51 [41·83-73·62]; males, 67·33 [50·78-86·43]; females, 46·50 [32·70-62·38]), T2DM (18·49 [17·18-19·66]; males, 19·94 [18·50-21·32]; females, 17·30 [15·62-18·70]) and NAFLD (2·09 [1·61-2·60]; males, 2·38 [1·82-3·02]; females, 1·82 [1·41-2·27]). Similarly, obesity (1932·54 [1276·61-2639·74]) had the highest age-standardised DALYs, followed by hypertension (2885·57 [2580·75-3201·05]), hyperlipidemia (1207·15 [975·07-1461·11]), T2DM (801·55 [670·58-954·43]) and NAFLD (53·33 [40·73-68·29]). Mortality rates decreased over time in hyperlipidemia (-60%), hypertension (-47%), NAFLD (-31%) and T2DM (-20%), but not in obesity (107% increase). The highest metabolic-related mortality was observed in the Eastern Mediterranean and low SDI countries.

Conclusion
The growing prevalence of metabolic diseases, increasing obesity-related mortality trends, and the sex-regional-socioeconomic disparities evident in young adulthood, present the concerning global burden of metabolic diseases now and in the years ahead.
Geographic areas of responsibility among PCI-capable hospitals in the Philippines
Authors: Toledano B , Garganera K B , Prado J P , Sabas M L , Gregorio G S 
Published: January 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
The archipelagic nature of the Philippines is unique and the geographic areas of responsibility for ST elevation myocardial infarction patients should be defined.

Methodology
The list of registered PCI capable hospitals and the total members of adult interventional cardiologists per island from the Philippine Society of Cardiac Catheterization Incorporation as of January 2022 was used. Their characteristics were described using frequency and percentage. The web application Map Developers was utilized to locate the exact location of each PCI-capable center and a 120km radius at the center of each PCI-capable hospital was drawn. The 120km radius was based on the average of 60km/hour from the Land Transportation & Traffic code multiplied by 2 hours based on the maximum expected delay from STEMI diagnosis to primary PCI. The map of Philippine provinces was obtained from the Creative Commons Attribution-Share Alike 4.0 international file name Ph administrative map blank. The maps of the geographic area of responsibility and provinces were interposed using MS PowerPoint version 2201 and categorized as covered, partially covered, and not covered.

Results
The analysis included a total of 3 islands with 82 provinces, 244 adult interventional cardiologists (IC) and 54 PCI-capable hospitals. The region registered the highest percentage of IC (85.7%) and PCI-capable hospitals (78.9%) followed by Visayas (8.6%) and (11.5%), and Mindanao (5.7%) and (9.6%) respectively. Most PCI-capable hospitals are privately (79.6%) versus government owned (20.4%). Most percentage of PCI-capable hospitals are in Metro Manila (46.3%), followed by Cebu (9.26%), Laguna and Pampanga (5.57%), Benguet, Davao del Sur, Misamis Oriental, Nueva Ecija and Iloilo (3.7%). Only 46.4% of the provinces are covered, 34.1% are partially covered and 19.5% are not covered.

Conclusion
In the Philippines, most PCI-capable hospitals are privately owned and centrally located on an island. There may be a need to add PCI-capable hospitals that are government owned, equally distributed, and strategically placed in partially and non-covered provinces. In addition, due to its archipelagic nature, STEMI patients in other provinces that are not covered may benefit from rapid fibrinolysis.
Engineering a fermenting yeast able to produce the fragrant β-ionone apocarotenoid for enhanced aroma properties in wine
Authors: Timmins John , van Wyk Niel , Kroukamp Heinrich , Walker Roy , Fritsch S , Rauhut Doris , Wallbrunn Christian , Pretorius Isak , Paulsen Ian 
Published: January 2023

Abstract
Wine is composed of multitudinous flavour components and volatile organic compounds that provide this beverage with its attractive properties of taste and aroma. The perceived quality of a wine can be attributed to the absolute and relative concentrations of favourable aroma compounds; hence, increasing the detectable levels of an attractive aroma, such as β-ionone with its violet and berry notes, can improve the organoleptic qualities of given wine styles. We here describe the generation of a new grape-must fermenting strain of Saccharomyces cerevisiae that is capable of releasing β-ionone through the heterologous expression of both the enzyme carotenoid cleavage dioxygenase 1 (CCD1) and its substrate, β-carotene. Haploid laboratory strains of S. cerevisiae were constructed with and without integrated carotenogenic genes and transformed with a plasmid containing the genes of CCD1. These strains were then mated with a sporulated diploid wine industry yeast, VIN13, and four resultant crosses—designated MQ01–MQ04–which were capable of fermenting the must to dryness were compared for their ability to release β-ionone. Analyses of their fermentation products showed that the MQ01 strain produced a high level of β-ionone and offers a fermenting hybrid yeast with the potential to enhance the organoleptic qualities of wine.
Rayleigh wave spectral distortions induced by an anticline structure
Authors: El Khoury Christine , Chauris Hervé , Kazantsev Alexandre , Monteiller Vadim 
Published: January 2023

SUMMARYSpectral anomalies in the seismic ambient noise are commonly observed above hydrocarbon reservoirs at frequencies of several Hertz. If properly understood, these anomalies could be a potential indicator for hydrocarbon reservoir exploration or monitoring. Under the assumption that ambient noise mainly consists of surface waves, previous studies showed that the geological structure, rather than the hydrocarbon content, could be the major cause of the observed anomalies for purely elastic waves. This work further explores how Rayleigh waves interact with an anticline structure, a typical geological trap for a hydrocarbon reservoir. We propose an approximate semi-analytical surface wave approach for modelling the spectral anomalies. It is based on the contribution of 1-D local solutions from two different models. The results are compared with those obtained via 3-D numerical simulations using the spectral-element approach in the case of a wavefield dominated by Rayleigh waves. Analysis of the anomalies generated by an anticline structure is performed for different source configurations. It shows that the semi-analytical method provides reasonable spectrum predictions for smooth layered models and under some restrictions on the source distribution. Such a tool allows us to run a larger number of simulations to explore the parameter space and finally provide a general law linking the anticline geometrical parameters and the elastic properties of the medium to the anticline-induced spectral anomaly for the case of fundamental mode Rayleigh waves.
Care Work Is Not Conditional: Contingent Labor and “Vocation” in Theological and Religious Studies
Authors: Koh SueJeanne , Capps Franklin Tanner 
Published: January 2023

Abstract
This article is written for people working in the related fields of theological and religious studies, speaking directly to the issue of contingency as a feminist question of care. It acknowledges how cisgendered women in the academy often bear the bulk of caring for others, but goes further, interrogating how care discourses structurally inform the contingent worker’s material realities. Contingency raises the question of the value of the humanities, of which theological and religious studies are a part. Framed as a question of “vocation,” Max Weber argues that the humanities scholar’s work should be oriented to research, rather than moral transformation. A critical and feminist analysis of care, then, unveils contingent labor as a kind of care work that supports masculinist attachments to the tenure track faculty position as the pinnacle of effort and scholarship. The article offers first steps toward constructive recommendations for the issues that we identify.
ISDS and Its Transformations
Authors: Ortino Federico 
Published: January 2023

ABSTRACT
Like the Journal of International Economic Law, which we celebrate with this special 25th Anniversary issue, investor-state dispute settlement (ISDS) came to life in the second half of the 1990s. The aim of this contribution is to ask whether ISDS has gone through any ‘transformation’, that is any ‘complete’ or ‘radical’ change, in the last twenty-five years. The article argues that, while a lot has changed in two and a half decades, in particular, the amount and breadth of criticism against investor-state arbitration, ISDS remains fundamentally the same, at least if one focuses on the practice of ISDS.
Overcoming contractual incompleteness: the role of guiding principles
Authors: Frydlinger David , Hart Oliver 
Published: January 2023

Abstract
Transactions of any complexity between buyers and sellers are supported by long-term contracts and these contracts are inevitably incomplete. We propose an approach for overcoming contractual incompleteness based on the idea that most people are inclined to follow widely accepted social norms, such as being fair-minded and acting with integrity. We suggest that this tendency can be reinforced if these social norms are incorporated into a formal contract in the form of guiding principles. We develop a model in which guiding principles reduce shading behavior and discuss cases where the approach has been successfully applied in practice (JEL D23, D86, K12).
Automatic attention to sexual stimuli: exploring the role of neuroticism and sexual excitation/inhibition through event-related potentials
Authors: Aguiar Sandra , Carvalho Joana , Carrito Mariana L , Santos Isabel M 
Published: January 2023

AbstractBackgroundPrevious findings have shown that neuroticism is a higher-order vulnerability factor in the development and maintenance of sexual dysfunctions and can have an impact on the attentional processing of sexual stimuli; however, the influence of psychosexual dimensions on the early automatic phases of such cognitive processes has not been established yet.AimTo examine the mediating role of sexual inhibition/excitation propensity in the relationship between neuroticism and automatic attention to visual erotica and to identify the neuroelectric correlates of such a process.MethodsWe analyzed the answers provided by 58 individuals on the Neuroticism subscale of the NEO Personality Inventory–Revised and the Sexual Inhibition/Excitation Scales. Event-related potentials (ERPs) were recorded during a modified oddball paradigm containing romantic and sexually explicit pictures. Parallel mediations were performed to simultaneously test the mediating role of sexual inhibition/excitation in the relationship between neuroticism and each ERP.OutcomesThree early attention ERP components (P1, P2, and N2) were assessed.ResultsFindings revealed an indirect effect of neuroticism on automatic attention, via sexual inhibition due to threat of performance failure (SIS1), for romantic and sexually explicit stimuli. This effect was significant only for component N2, which showed increased amplitudes and earlier latencies in participants with high SIS1.Clinical ImplicationsSexual stimuli, due to their emotional valence and arousal potential, might be perceived as virtually threatening by individuals with neuroticism, who may benefit from strategies that decrease hyperarousal and sympathetic activation.Strengths and LimitationsThis was one of the first studies to analyze neuroelectric activity associated with automatic attention toward sexual stimuli in relation to personality and sexual excitation/inhibition propensity. Nevertheless, the limited number of participants demands caution in generalizing the results.ConclusionThese results provide a better understanding of the relationship between personality and sexual cognition and open new avenues of research in relation to other automatic cognitive phenomena related to human sexual behavior.