bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Progress in the Development of New Antiepileptic Drugs with Novel Targets
Authors: Belete Tafere Mulaw 
Published: August 2023

Background Epilepsy is a chronic neurological disorder that affects approximately 50–70 million people worldwide. Epilepsy has a significant economic and social burden on patients as well as on the country. The recurrent, spontaneous seizure activity caused by abnormal neuronal firing in the brain is a hallmark of epilepsy. The current antiepileptic drugs provide symptomatic relief by restoring the balance of excitatory and inhibitory neurotransmitters. Besides, about 30% of epileptic patients do not achieve seizure control. The prevalence of adverse drug reactions, including aggression, agitation, irritability, and associated comorbidities, is also prevalent. Therefore, researchers should focus on developing more effective, safe, and disease-modifying agents based on new molecular targets and signaling cascades. Summary This review overviews several clinical trials that help identify promising new targets like lactate dehydrogenase inhibitors, c-jun n-terminal kinases, high mobility group box-1 antibodies, astrocyte reactivity inhibitors, cholesterol 24-hydroxylase inhibitors, glycogen synthase kinase-3 beta inhibitors, and glycolytic inhibitors to develop a new antiepileptic drug. Key messages Approximately 30% of epileptic patients do not achieve seizure control. The current anti-seizure drugs are not disease modifying, cure or prevent epilepsy. Lactate dehydrogenase inhibitor, cholesterol 24-hydroxylase inhibitor, glycogen synthase kinase-3 beta inhibitors, and mTOR inhibitors have a promising antiepileptogenic effect.
Nonlinear coupling vibration analyses of large-scale wind turbine system
Authors: Chen Junling , Wan Zhaocong , Zhao Bangzhou , Qiu Xu 
Published: August 2023

With the development of wind energy, the unit capacity of wind turbine is becoming larger and the height of the support tower is getting higher. Limited by the transport conditions, the diameter of the tubular steel tower cannot further increase with the increase of the tower height, which results in the lower natural frequencies of the tower. The higher and more slender wind turbine towers are more sensitive to the external excitation and many tower collapses have occurred in recent years because of the interplay with the longer rotor blades. A 2 MW wind turbine system with a 120 m full steel tubular tower is taken as an example in this study to research the nonlinear coupling vibration mechanism under the normal operation case and the emergency shut-down case. An integrated model of large-scale wind turbine system including the tower, blades, hub, and nacelle is established by the open-source software FAST to study its nonlinear interaction vibration mechanism. Under the normal operation load case, the acceleration response of the steel wind turbine tower is greatly affected by the rotational frequency of the rotor. The maximum accelerations in the fore-aft and side-side directions both appear around the middle-upper height of the tower. Under the emergency shut-down load case, the maximum fore-aft acceleration response appears at the top of the tower, but the maximum side-side response still appears around the middle-upper height of the tower. The first-order vibration mode plays a dominant role in the top fore-aft acceleration and the second-order vibration mode has great contribution to the side-side acceleration under the emergency shut-down load case. The numerical results of this study can provide insight into the vibration control mechanism of the full steel tower.
Experimental and theoretical studies on postfire behavior of functionally graded ultra-high performance concrete
Authors: Du Linpu , Ji Xuping , Lu Kaiwei , Wang Jingquan 
Published: August 2023

In order to improve structural fire-resistant behaviors, this paper designed a two-layer functionally graded ultra-high performance concrete (FGUHPC) structure composed of a UHPC layer and a lightweight aggregate concrete (LWAC) layer. UHPC layers are adopted to provide structural bearing capacity and protected by LWAC layers from elevated temperature. Splitting tensile tests and three-point flexural tests were conducted under ambient and elevated temperatures to evaluate interfacial bond performance and flexural bearing capacity, where two interfacial treatments were adopted and compared. The experimental results revealed that FGUHPC members exhibited good integrity during heating, no explosive spalling occurred and the maximal temperature at interfacial regions was 266°C. The interfaces showed desirable bond performance under ambient temperature while the splitting tensile strength was decreased by around 85% in the case of high temperature. Flexural test results indicated that the structural stiffness would be reduced by around 42% under elevated temperature, as a result, the maximal deflection was increased from 2.5 mm to 3.7 mm. SWM could significantly improve interfacial bond performance and prevent debonding failure of specimens at the postfire state, leading to higher structural bearing capacities. The bearing capacities of specimens with and without interfacial treatments were 42.7 kN and 38.4 kN respectively under ambient temperature, which remained about 88% after elevated temperature.
Quality and Readability of Spanish-Language Online Information for Aortic Aneurysm and Its Endovascular Treatment
Authors: San Norberto Enrique M. , Revilla Álvaro , Brizuela José A. , Taylor James H. 
Published: August 2023

Background Aortic aneurysms represent a chronic degenerative disease with life-threatening implications. In order for patients to comprehend health related information, it must be written at a level that can be readily understood. Study Design In January 2023, we searched “aneurisma aorta” and “endoprótesis aorta” terms on Google, Yahoo and Microsoft/Bing. The 31th websites provided by each search engine were analyzed. Four readability measures were used to evaluate websites regarding aortic aneurysm and their endovascular treatment in Spanish language: Flesch Index, Flesch-Szigriszt Index, Fernández-Huerta Index and grading Inflesz scale. The quality on information was evaluated by the HONcode seal, the DISCERN instrument and the JAMA benchmark criteria. Results 180 websites containing the terms “aneurisma aorta” and “endoprótesis aorta” were analyzed. Among the websites retrieved, the mean Flesh index score (53.12 ± 6.09 and 47.48 ± 7.12, respectively; P = .019), the Flesch-Szigriszt index (56.39 ± 5.72 and 48.10 ± 8.33; P = .000), and the Fernández Huerta index (61.30 ± 5.59 and 53.19 ± 8.21; P = .000), corresponding to a “somewhat difficult” readability level. In addition, the Inflesz scale (2.62 ± .59 and 2.07 ± .61; P = .000) reported a “somewhat difficult” readability, higher for the websites regarding aortic aneurysm. The HONcode seal was only presented in websites regarding aortic aneurysm (16.7%), whereas none of the websites relating to aortic endoprostheses presented it (0%) ( P = .000). Websites that presented the HONcode seal obtained higher DISCERN score ( P = .000, 95% CI = 6.42-16.84) and JAMA score (P = .000, 95% CI = 3.44-11.32). Conclusion Internet information on aortic aneurysms and aortic endoprostheses is too difficult to read for the general Spanish-speaking population and is lacking in quality.
Association between serum trace elements and sleep disturbance in patients with decompensated cirrhosis
Authors: Zhang Ziyue , Hui Yangyang , Yang Wanting , Guo Gaoyue , Cui Binxin , Li Chaoqun , Wang Xiaoyu , Fan Xiaofei , Sun Chao 
Published: August 2023

Background: Sleep disturbance and trace elements imbalance are common features in patients with decompensated cirrhosis, partially sharing similar mechanistic contributors and linking to adverse outcomes. However, there is a paucity of data concerning their relationship. Objectives: To investigate the association between serum trace elements levels and sleep quality in the context of cirrhosis. Design: Cross-sectional study. Methods: We consecutively enrolled 160 patients with decompensated cirrhosis. The sleep disturbance was determined by the Pittsburgh Sleep Quality Index (PSQI > 5). Serum trace elements [magnesium, calcium, iron, copper (Cu), zinc (Zn), lead, and manganese] was measured by inductively coupled plasma mass spectrometry. Association of examined trace elements levels and sleep disturbance was analyzed by multiple linear (global PSQI scores) and multivariate logistic (dichotomized PSQI categories) regression models, respectively. Results: In total, 91 patients (56.88%) represented PSQI-defined sleep disturbance, characterized by female preponderance, lower body mass index levels, and higher serum Cu levels (all p < 0.05). Looking into its clinical relevance with debilitating conditions, we showed that Cu/Zn ratio (CZr) is significantly higher in cirrhosis with poor sleep quality (1.77 versus 1.48, p = 0.003). Diagnostic performance analysis indicated CZr > 1.62 to exhibit better discrimination relative to respective Cu. Both multiple linear (β = 0.355, p < 0.001) and multivariate logistic regression (odds ratio = 2.364, p = 0.019) identified higher CZr as an independent risk factor associated with sleep disturbance. Conclusion: Our findings implied an association between higher CZr and the presence of sleep disturbance in patients with decompensated cirrhosis.
Cervical Disc Arthroplasties Fail to Maintain Physiological Kinematics Under Lateral Eccentric Loads
Authors: Roch Paul Jonathan , Hemprich Constantin , Klockner Friederike , Meier Marc-Pascal , Jäckle Katharina , Lehmann Wolfgang , Wachowski Martin Michael , Weiser Lukas 
Published: August 2023

Study design In vitro human cadaveric biomechanical analysis. Objectives Optimization of prostheses for cervical disc arthroplasties (CDA) reduces the risk of complications. The instantaneous helical axis (IHA) is a superior parameter for examining the kinematics of functional spinal units. There is no comprehensive study about the IHA after CDA considering all 3 motion dimensions. Methods Ten human functional spinal units C4-5 (83.2 ± 7.9 yrs.) were examined with an established measuring apparatus in intact conditions (IC), and after CDA, with 2 different types of prostheses during axial rotation, lateral bending, and flexion/extension. Eccentric preloads simulated strains. The IHA orientation and its position at the point of rest (IHA0-position) were analyzed. Results The results confirmed the existing data for IHA in IC. Lateral preloads showed structural alterations of kinematics after CDA: During axial rotation and lateral bending, the shift of the IHA0-position was corresponding with the lateral preloads’ applied site in IC, while after CDAs, it was vice versa. During lateral bending, the lateral IHA orientation was inclined, corresponding with the lateral preloads’ applied site in the IC and oppositely after the CDAs. During flexion/extension, the lateral IHA orientation was nearly vertical in the IC, while after CDA, it inclined, corresponding with the lateral preloads’ applied site. The axial IHA orientation rotated to the lateral preloads’ corresponding site in the IC; after CDA, it was vice versa. Conclusion Both CDAs failed to maintain physiological IHA characteristics under lateral preloads, revealing a new aspect for improving prostheses’ design and optimizing their kinematics.
Thalassemia carrier status and groundwater iron: Implication for iron supplementation program for children in Bangladesh
Authors: Rahman Sabuktagin , Lee Patricia , Khan Moududur Rahman , Ahmed Faruk 
Published: August 2023

Background: Thalassemia, a congenital disorder of hemoglobin synthesis is characterized by low hemoglobin and high iron status, is prevalent in Bangladesh. Iron, consumed through drinking groundwater also increases the population iron status in Bangladesh. The study examined the effect of iron containing micronutrient powder (MNP) on the hemoglobin and ferritin status in Bangladeshi children with thalassemia and their non-thalassemia peers exposed to a high concentration of iron from drinking groundwater. Design and methods: Three hundred twenty-seven children aged 2–5 years were recruited for an MNP efficacy trial. A sub sample ( n = 222) were screened for thalassemia. Hemoglobin and ferritin levels were measured in children with and without thalassemia. Intake of iron from the key sources—diet, groundwater and MNP was measured. Mann Whitney and t-test were employed to compare the groups. Results: Hemoglobin concentration of the children with thalassemia at the endpoint remained unchanged relative to the baseline; 11.56 ± 0.59 g/dL (Endpoint) versus 11.6 ± 0.54 g/dL (Baseline), p = 0.83. In children without thalassemia hemoglobin tended to increase; 12.54 ± 0.72 g/dL (Endpoint) versus 12.41 ± 0.72 g/dL (baseline), p = 0.06. Baseline reserve of body iron was significantly ( p = 0.03) higher in thalassemia carriers (594 gm) compared to their non-carrier peers (558 gm). The increase of the infection-adjusted ferritin from baseline to the endpoint was 7.37% ( p = 0.7) and 10.17% ( p = 0.009) in the carrier and non-carrier groups respectively. Conclusions: In Bangladesh, the coexistence of thalassemia and the exposure to a high concentration of iron from drinking groundwater renders anemia prevention program with a low iron MNP potentially lesser hazardous to the thalassemia carriers.
Assessment of macular pigment optical density in Arab population and its relationship to people’s anthropometric data: a cross-sectional study
Authors: Alsaqr Ali , Alharbi Manal , Aldossary Noura , Alruwished Abdulaziz , Alharbi Mohammed , Alghaib Khalid , Alabdulkarim Abeer , Alhamdan Shatha , Almutleb Esam , Abusharha Ali 
Published: August 2023

Background: Anthropometry facilitates the evaluation of risks associated with reduced macular pigment optical density (MPOD). Objectives: To investigate the predictors and anthropometric indices associated with MPOD in healthy adult in Arab population. Design: This is a cross-sectional study. Methods: The MPOD was measured at 0.5° from fovea using a heterochromatic flicker photometer. Healthy participants aged between 20 and 40 years were recruited. The study evaluated the following data of the participants: height, weight, body mass index, body fat percentage, basal metabolic rate, visceral fat level, muscle mass, bone mineral content, and percentage of protein and body water. The correlation between MPOD with anthropometrics and demographic data was evaluated using Spearman’s correlation test. The differences among genders were investigated using the Mann–Whitney U test. The smoking effect on MPOD was analyzed using the Friedman test. Results: In all, 143 participants were recruited. The median ± interquartile range was calculated for age (23 ± 4 years), visual acuity (0.00 ± 0.00 logMAR), and MPOD (0.41 ± 0.18). The average MPOD was higher in males than in females but it was not statistically significant ( p > 0.05); on the other hand, they were statistically significantly different in most of the anthropometric data. A significant relationship was found between MPOD and percentage of body fat, protein, and body water ( r = 0.30, p < 0.05). The observed median MPOD value was higher in this study than that found in previous studies in white populations, but lower than that found in studies investigating Asian populations. Conclusion: One of the most important risk factors of age-related macular degeneration is associated with a relative absence of macular pigment. This study brought into focus percentage of protein and body water for further studies as well as the well-established links with body fat and obesity. Unknown predictors of MPOD remain uncovered. The study also provided first report on normative values of MPOD for Arab population and confirmed the differences from other ethnicities.
Promotore-Led Versus Registered Nurse-Led Diabetes Self-Management Education in Mexican Americans: A Randomized Clinical Trial
Authors: Kopelowicz Alex , Wali Soma , Polzin Rhonda , Ruiz Maria Elena , Nandy Karabi 
Published: August 2023

Purpose: The purpose of this study is to compare the benefits of a diabetes self-management program led by registered nurses (RNs) versus community health workers ( promotores) for Spanish-speaking Mexican Americans with type 2 diabetes (T2DM). Methods: Three hundred thirty Spanish-speaking Mexican American adults with T2DM were randomly assigned to “Tomando Control de Su Diabetes” delivered for six 2.5-hour sessions either by promotores or RNs. The primary outcome measure was the Summary of Diabetes Self-Care Activities (SDSCA). Evaluations were made at baseline, 6 weeks, and at 3, 6, and 12 months. Mixed-effects regression models were fit to test if participants had differential changes in the SDSCA total score by group over time, controlling for demographic and clinical factors. Results: SDSCA scores were significantly higher at all time points compared to baseline and not statistically different between the 2 groups. Only years of education correlated with improvement in diabetes self-management behaviors. No moderating variables predicted improvement between groups. Conclusions: Spanish-speaking Mexican American adults with T2DM who participated in a diabetes educational program with promotores or RNs demonstrated similar improvements. Promotores may increase the accessibility of effective diabetes self-management training for this difficult-to-reach population.
Prospecting and characterization of plastic clays from the state of São Paulo, Brazil, as raw materials for porcelain stoneware tile production
Authors: Christofoletti Sérgio Ricardo , Motta José Francisco Marciano , Meneghel Eduardo Camargo , Melchiades Fábio Gomes 
Published: August 2023

AbstractThe present work aims to prospect and study the plastic and superplastic clay deposits in the state of São Paulo, Brazil, as a source of raw materials for the ceramic tile industry and especially for the production of porcelain stoneware tiles. To achieve the proposed objectives, a geological study was carried out through the mapping and identification of the present lithologies, lithogeochemical characterization using X-ray diffraction, inductively coupled plasma optical emission spectrometry, cation-exchange capacity and organic carbon and characterization of the ceramic technological properties, including granulometric analysis by sedigraph and Brunauer–Emmett–Teller specific surface area. According to their geological characteristics, the studied deposits were classified into two types: a detrital sedimentary deposit, restricted to Quaternary alluvial sediments and Neogenic Tertiary formations and composed of silt-sandy clay and plastic, kaolinitic, refractory and silico-aluminous facies; and an alterite type, found in Permo-Carboniferous rocks of the Paraná Basin, composed of laminated/massive weathering siltstones, with the highly plastic, fluxing clay minerals illite, kaolinite and smectites. Among the targets studied in these deposits, argillaceous facies with plastic and superplastic characteristics were identified, which affect their applicability in compositions for producing porcelain stoneware tiles and stoneware.
Advanced brain MRI may help understand the link between migraine and multiple sclerosis
Authors: Huang Susie Y. , Salomon Marc , Eikermann-Haerter Katharina 
Published: August 2023

Abstract
Background
There is a clinical association between migraine and multiple sclerosis.

Main body
Migraine and MS patients share similar demographics, with the highest incidence among young, female and otherwise healthy patients. The same hormonal constellations/changes trigger disease exacerbation in both entities. Migraine prevalence is increased in MS patients, which is further enhanced by disease-modifying treatment. Clinical data show that onset of migraine typically starts years before the clinical diagnosis of MS, suggesting that there is either a unidirectional relationship with migraine predisposing to MS, and/or a “shared factor” underlying both conditions. Brain imaging studies show white matter lesions in both MS and migraine patients. Neuroinflammatory mechanisms likely play a key role, at least as a shared downstream pathway. In this review article, we provide an overview of the literature about 1) the clinical association between migraine and MS as well as 2) brain MRI studies that help us better understand the mechanistic relationship between both diseases with implications on their underlying pathophysiology.

Conclusion
Studies suggest a migraine history predisposes patients to develop MS. Advanced brain MR imaging may shed light on shared and distinct features, while helping us better understand mechanisms underlying both disease entities.
rBahadur: efficient simulation of structured high-dimensional genotype data with applications to assortative mating
Authors: Border Richard , Malik Osman Asif 
Published: August 2023

AbstractExisting methods for generating synthetic genotype data are ill-suited for replicating the effects of assortative mating (AM). We propose _, a novel and computationally efficient algorithm for generating high-dimensional binary random variates that effectively recapitulates AM-induced genetic architectures using the Bahadur order-2 approximation of the multivariate Bernoulli distribution. The R library is available through the Comprehensive R Archive Network at https://CRAN.R-project.org/package=rBahadur.
Comparing antimicrobial resistant genes and phenotypes across multiple sequencing platforms and assays for Enterobacterales clinical isolates
Authors: Rose Rebecca , Nolan David J. , Ashcraft Deborah , Feehan Amy K. , Velez-Climent Leonor , Huston Christopher , Lain Benjamin , Rosenthal Simon , Miele Lucio , Fogel Gary B. , Pankey George , Garcia-Diaz Julia , Lamers Susanna L. 
Published: August 2023

Abstract
Introduction
Whole genome sequencing (WGS) of bacterial isolates can be used to identify antimicrobial resistance (AMR) genes. Previous studies have shown that genotype-based AMR has variable accuracy for predicting carbapenem resistance in carbapenem-resistant Enterobacterales (CRE); however, the majority of these studies used short-read platforms (e.g. Illumina) to generate sequence data. In this study, our objective was to determine whether Oxford Nanopore Technologies (ONT) long-read WGS would improve detection of carbapenem AMR genes with respect to short-read only WGS for nine clinical CRE samples. We measured the minimum inhibitory breakpoint (MIC) using two phenotype assays (MicroScan and ETEST) for six antibiotics, including two carbapenems (meropenem and ertapenem) and four non-carbapenems (gentamicin, ciprofloxacin, cefepime, and trimethoprim/sulfamethoxazole). We generated short-read data using the Illumina NextSeq and long-read data using the ONT MinION. Four assembly methods were compared: ONT-only assembly; ONT-only assembly plus short-read polish; ONT + short-read hybrid assembly plus short-read polish; short-read only assembly.

Results
Consistent with previous studies, our results suggest that the hybrid assembly produced the highest quality results as measured by gene completeness and contig circularization. However, ONT-only methods had minimal impact on the detection of AMR genes and plasmids compared to short-read methods, although, notably, differences in gene copy number differed between methods. All four assembly methods showed identical presence/absence of the blaKPC-2 carbapenemase gene for all samples. The two phenotype assays showed 100% concordant results for the non-carbapenems, but only 65% concordance for the two carbapenems. The presence/absence of AMR genes was 100% concordant with AMR phenotypes for all four non-carbapenem drugs, although only 22%—50% sensitivity for the carbapenems.

Conclusions
Overall, these findings suggest that the lack of complete correspondence between CRE AMR genotype and phenotype for carbapenems, while concerning, is independent of sequencing platform/assembly method.