bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cochlear Implantation: The use of OTOPLAN Reconstructed Images in Trajectory Identification
Authors: Hajr Eman , Abdelsamad Yassin , Almuhawas Fida , Alashour Amnah , Hagr Abdulrahman 
Published: January 2023

Objectives This study aimed to define the best electrode trajectory line in cochlear implant (CI) surgery using the OTOPLAN (otology planning software) reconstructed 3D model and to investigate the surgical distance of the retro-facial approach as a direct access to the round window. Methods Computed tomography (CT) scans of the normal temporal bone were included for analysis in this study. OTOPLAN reconstruction was used to build 3D models with specific ear structures for study analysis. Results Twenty-five scans were included; the average age at the time of CT scan was 6.8±12 years. Twelve scans (48%) were right-sided and thirteen (52%) were left-sided. The best trajectory line to the round window was identified in all scans. The retro-facial approach was the optimal approach for 52% of cases (13/25). In all scans, the safe distance from the facial nerve were in favor of the retro-facial approach (P = 0.0011). Conclusion The OTOPLAN reconstructed imaging provided a good analysis of the retro-facial approach and helped in planning the surgical trajectory line towards the round window. Additionally, calculation of the surgical distance can help the surgeon compare the retro-facial approach to the standard facial recess for preoperative planning. These findings may help in robotic surgery.
Short-term Clinical Outcome of Previously Untreated and Treated Schizophrenia and Impact of Duration of Untreated Psychosis
Authors: Bansal Priyanka , Saini Bhavneesh , Sharma Arvind , Bansal Pir Dutt , Moria Kavita , Saini Sumit , Singh Baltej 
Published: January 2023

Background: Duration of untreated psychosis (DUP) is an important modifiable factor affecting schizophrenia outcomes. A dearth of research in India on untreated versus treated schizophrenia warrants further research. Methods: This was a longitudinal study in a tertiary hospital over 2 years. Inpatients diagnosed with schizophrenia ( N = 116), aged 18–45, were divided into untreated and treated groups. Diagnostic confirmation, severity assessment, and clinical outcome were done using ICD-10 criteria, Positive and Negative Syndrome Scale (PANSS), and Clinical Global Impression (CGI) scale. Follow-up was done at 12 and 24 weeks. DUP was measured, and its association with the outcome was assessed. Results: Final analysis included 100 patients, 50 each of previously untreated and treated. Untreated patients had lower age and duration of illness (DOI), but higher DUP ( p < .001). Treated patients showed much improvement on CGI-I at 12 weeks ( p = .029), with no difference at 24 weeks. PANSS severity comparison showed no difference, and both groups followed a declining trend. In untreated patients, age of onset (AoO) was negatively correlated with severity (except general symptoms at baseline) at all follow-ups (‘ r’ range = −0.32 to –0.49, p < .05), while DOI showed a positive correlation with negative and general symptoms at 12 weeks ( r ~ 0.3, p < .05). Treated patients showed inconsistent and lower negative correlation between AoO and PANSS, with no correlation between severity and DOI. The mean sample DUP was 17.9 ± 31.6 weeks; it negatively correlated with education ( r = –0.25, p = .01) and positively with PANSS severity (‘ r’ range = 0.22 to 0.30, p < .05) at all follow-ups, especially negative symptoms. Patients with no or minimal improvement on CGI at 24 weeks had higher DUP (Quade’s ANOVA F[1,98] = 6.24, p = .014). Conclusion: Illness variables in untreated schizophrenia affect severity, which has delayed improvement than treated schizophrenia. Higher DUP is associated with negative symptoms of schizophrenia.
Multi-factor analysis of failure for modified single-session Angiojet rheolytic thrombectomy in treatment of acute iliofemoral venous thrombosis from iliac vein compression syndrome
Authors: Huang Tianan , Ding Wenbin , Jin Yonghai , Jin Jie , Deng Xiaowen , Liang Li , Chen Zhuo , Hong Xin 
Published: January 2023

Purpose To explore the risk factors of failure for modified single-session Angiojet rheolytic thrombectomy combined with directed iliac vein stenting, directed filter retrieval in the treatment of iliac vein compression with iliofemoral vein thrombosis. Methods During September 2017 to September 2021, 278 patients with DVT were retrospectively analyzed and 203 were eligible for inclusion. All patients were tried to take modified single-session Angiojet rheolytic thrombectomy combined with directed iliac vein stenting, directed filter retrieval treatment. The perioperative factors were analyzed between groups: group 1—modified single-session therapy succeed, and group 2—modified single-session therapy failed. The high risk factors of failure group were evaluated by logistic regression analysis. Results 48 patients failed in modified single-session therapy, up to 23.64%. Single factor analysis indicated that there were five independent risk factors related with the failure ( p < 0.05), including course of disease longer than 7 days, lumbar degeneration-related iliac vein compression syndrome (dIVCS), antegrade vein access, balloon-assisted cracking thrombus, and suction time. Logistic regression analysis indicated that course of disease longer than 7 days (OR = 19.642.95%CI:6.776∼56.933), dIVCS (OR = 11.586.95%CI:4.016∼33.427) were high risk factors for modified single-session therapy failed, antegrade vein access (OR = 0.171.95%CI:0.047∼0.614) and balloon-assisted cracking thrombus (OR = 0.157.95%CI:0.045∼0.542) were protective factors for therapy failure ( p < 0.05). Conclusions Long course of disease and dIVCS are the high risk factors for failure of modified single-session Angiojet rheolytic thrombectomy combined with directed iliac vein stenting, directed filter retrieval in the treatment of iliac vein compression syndrome (IVCS). But, antegrade vein access and balloon-assisted cracking thrombus intraoperatively may improve the success rate of modified single-session treatment.
Varicose veins as a risk factor for venous thromboembolism in arthroplasty patients: Meta-analysis
Authors: Westby Daniel , Ghoneim Baker M , Nolan Fiona , Elsharkawi Mohamed , Maguire Sean , Walsh Stewart R 
Published: January 2023

Objective A meta-analysis to determine if patients with varicose veins are at an increased risk of venous thromboembolism (VTE) when undergoing major lower limb arthroplasty. Methods Medline, Embase, and Cochrane Library databases were searched using appropriate terms for studies that reported post-operative VTE in patients who had lower limb arthroplasty with any history of varicose veins. Methodological quality of included studies was quantified using the Risk of Bias (ROB) assessment tools. Findings were reported using the meta-analysis of observational studies in epidemiology (MOOSE) checklist. Results A total of 129 studies were identified with 11 observational studies being eligible for inclusion. This consisted of 265,194 patients who underwent lower limb arthroplasty, 2188 of which had pre-existing varicose veins. Overall, VTE occurred in 1845 patients, and 122 cases had varicose veins present at time of arthroplasty. Meta-analysis indicates that patients undergoing lower limb arthroplasty with varicose veins are at increased risk of having a VTE, OR 2.37, 95% CI 1.54–3.63, ( p < 0.001). One study evaluated if previous varicose veins surgery influenced the risk of VTE in arthroplasty patients, OR 0.96 (95% CI 0.7–1.28), p = 0.429. Conclusions Varicose veins and lower limb arthroplasty are known independent risk factors for VTE. There is a paucity of data regarding the risk of VTE in patients undergoing lower limb arthroplasty who have co-existing varicose veins. This meta-analysis shows that patients with varicose veins are at an increased risk of VTE when undergoing major lower limb arthroplasty. Further studies are required in order to determine if such patients should undergo varicose vein surgery before undertaking major lower limb joint replacement.
The ICaRAS randomised controlled trial: Intravenous iron to treat anaemia in people with advanced cancer – feasibility of recruitment, intervention and delivery
Authors: Dickson Edward A , Ng Oliver , Keeler Barrie D , Wilcock Andrew , Brookes Matthew J , Acheson Austin G 
Published: January 2023

Background: Anaemia is highly prevalent in people with advanced, palliative cancer yet sufficiently effective and safe treatments are lacking. Oral iron is poorly tolerated, and blood transfusion offers only transient benefits. Intravenous iron has shown promise as an effective treatment for anaemia but its use for people with advanced, palliative cancer lacks evidence. Aims: To assess feasibility of the trial design according to screening, recruitment, and attrition rates. To evaluate the efficacy of intravenous iron to treat anaemia in people with solid tumours, receiving palliative care. Design: A multicentre, randomised, double blind, placebo-controlled trial of intravenous iron (ferric derisomaltose, Monofer®). Outcomes included trial feasibility, change in blood indices, and change in quality of life via three validated questionnaires (EQ5D5L, QLQC30, and the FACIT-F) over 8 weeks. (ISRCTN; 13370767). Setting/Participants: People with anaemia and advanced solid tumours who were fatigued with a performance status ⩽2 receiving support from a specialist palliative care service. Results: 34 participants were randomised over 16 months (17 iron, 17 placebo). Among those eligible 47% of people agreed to participate and total study attrition was 26%. Blinding was successful in all participants. There were no serious adverse reactions. Results indicated that intravenous iron may be efficacious at improving participant haemoglobin, iron stores and select fatigue specific quality of life measures compared to placebo. Conclusion: The trial was feasible according to recruitment and attrition rates. Intravenous iron increased haemoglobin and may improve fatigue specific quality of life measures compared to placebo. A definitive trial is required for confirmation.
The viability and appropriateness of using visual methods in end of life research to foreground the experiences of people affected by financial hardship and deprivation
Authors: Richards Naomi , Quinn Sam , Mitchell Margaret , Carduff Emma , Gott Merryn 
Published: January 2023

Background: Visual methods have been used extensively in social research to explore people’s experiences of structural disadvantage. This indicates that they may provide a useful research approach to understanding equity-related concerns within palliative care. However, little has been published regarding the use of visual methods with people at the end of life. Purpose of the paper: In this article we draw on our experiences of using visual methods to illuminate the end of life experiences of people experiencing financial hardship and deprivation in Scotland’s largest city. Evidence used to support the information presented: We present evidence from the published literature, as well as our own experiences of using visual methods to explore dying at home for people experiencing financial hardship and deprivation. Our analysis draws on two specific visual methods: photovoice and professional photography. Photovoice is a participatory visual method which involves enabling participants to take and discuss their own images and present them to different audiences to try to enact social change. We report our experiences as researchers, as well as those of our participants and recruitment partners. Key learning points: To successfully use visual methods, researchers need to invest significant time and resource in building a strong rapport with participants. There are also key ethical, practical and representational challenges to consider. A participatory framework should be adopted which ensures agency for participants in terms of image creation and public dissemination. Participants reported value in using visual methods in terms of legacy building and self-representation. Using photovoice (insider’s view) and professional photography (outsider’s view) together offered complementary perspectives, enabling a rich layering of stories and meaning. Our findings indicate visual methods can illuminate aspects of the end of life experience not captured by other research methods.
Prescribing pattern of anticoagulants in patients with cancer associated thrombosis: Results of a survey among MITO group and AIOM society
Authors: Milani Andrea , Tuninetti Valentina , Pignata Sandro , Lorusso Domenica , Castaldo Daniele , De Giorgi Ugo , Savarese Antonella , Biglia Nicoletta , Scandurra Giuseppa , Mangili Giorgia , Di Maio Massimo , Turinetto Margherita , Bellero Marco , Mammoliti Serafina , Testa Silvia , Scotto Giulia , Purro Andrea , Artioli Grazia , Valabrega Giorgio 
Published: January 2023

Introduction: Low molecular weight heparin (LMWH) has been the backbone of the treatment of cancer associated thrombosis (CAT). Direct-acting oral anticoagulants (DOACs) have shown efficacy and safety not inferior to LMWH and guidelines included DOACs as an option for CAT treatment. Nevertheless, DOACs are still poorly prescribed in patients with cancer. The aim of this survey was to better understand prescription patterns of anticoagulants, in particular of DOACs, especially in gynecological cancers (GCs). Methods: Our survey was made up of 21 questions, the last four questions addressed to medical doctors (MDs) involved in GCs. An invitation to complete the survey was sent by e-mail to 691 MITO (Multicentre Italian Trials in Ovarian cancer and gynaecologic malignancies) and 2093 AIOM (Associazione Italiana di Oncologia Medica) members. Results: Overall, 113 MDs completed the questionnaire, 69 involved in GCs. Most respondents (46, 41%) were aged 30-40 years old, worked in public hospitals (59, 52.2%), were medical oncologists (86, 76.1%). LMWH was the preferred choice for the treatment of CAT (104, 92%). However, 89 respondents (78.8%) prescribed or asked to prescribe a DOAC for CAT. The major concern about DOACs was the difficulty in verifying the therapeutic effect and the absence of antidotes in case of bleeding (37.9%). In patients with GCs, DOACs were used with niraparib, olaparib, rucaparib and immune checkpoint inhibitors (ICIs) in less than 10 patients by 23%, 20%, 9% and 10.2% of respondents, respectively. Conclusion: The responders are aware of the Direct-acting oral anticoagulants option and would like to use them
Perceptions of Water Safety and Tap Water Taste and Their Associations With Beverage Intake Among U.S. Adults
Authors: Park Sohyun , Onufrak Stephen J. , Cradock Angie L. , Patel Anisha , Hecht Christina , Blanck Heidi M. 
Published: January 2023

Objectives Examine differences in perceptions of tap water (TW) and bottled water (BW) safety and TW taste and their associations with plain water (PW) and sugar-sweetened beverage (SSB) intake. Design Quantitative, cross-sectional study. Setting United States. Subjects 4,041 U.S. adults (≥18 years) in the 2018 SummerStyles survey data. Measures Outcomes were intake of TW, BW, PW (tap and bottled water), and SSB. Exposures were perceptions of TW and BW safety and TW taste (disagree, neutral, or agree). Covariates included sociodemographics. Analysis We used chi-square analysis to examine sociodemographic differences in perceptions and multivariable logistic regressions to estimate adjusted odds ratios (AOR) for consuming TW ≤ 1 cup/day, BW > 1 cup/day, PW ≤ 3 cups/day, and SSB ≥ 1 time/day by water perceptions. Results One in 7 (15.1%) of adults did not think their home TW was safe to drink, 39.0% thought BW was safer than TW, and 25.9% did not think their local TW tasted good. Adults who did not think local TW was safe to drink had higher odds of drinking TW ≤ 1 cup/day (AOR = 3.12) and BW >1 cup/day (AOR = 2.69). Adults who thought BW was safer than TW had higher odds of drinking TW ≤1 cup/day (AOR = 2.38), BW > 1 cup/day (AOR = 5.80), and SSB ≥ 1 time/day (AOR = 1.39). Adults who did not think TW tasted good had higher odds of drinking TW ≤ 1 cup/day (AOR = 4.39) and BW > 1 cup/day (AOR = 2.91). Conclusions Negative perceptions of TW safety and taste and a belief BW is safer than TW were common and associated with low TW intake. Perceiving BW is safer than TW increased the likelihood of daily SSB intake. These findings can guide programs and services to support water quality to improve perceptions of TW safety and taste, which might increase TW intake and decrease SSB intake.
“I don’t want to do time, I want to save it”: Carcerality of time and Black temporal resistance
Authors: Miles Corey J 
Published: January 2023

The criminalization of Blackness has led to premature death, high incarceration rates, and psychological stress, all of which impact Black people’s temporal horizons. Working in conversation with scholars who empirically documented how Blackness is criminalized and time is racialized, this work explores the degree in which carceral understandings of time provide a framework to better comprehend Black people’s temporal experiences. Data for this study include in-depth interviews with six students and 16 graduates from Historically Black Colleges and Universities (HBCUs) across six universities in the southern United States and 22 months of observations at a HBCU in southeastern United States. The results indicate that the respondents experience temporal traps that restrict the temporal possibilities of Black people and temporal stasis as they feel trapped within an ongoing history of anti-Black violence. They narrate a desire to “take their time” and “save time” to resist the dominant temporal order. The operative “take” signifies the creating of temporal possibility through uncoupling time’s relation to racial structures and “save” signifies freeing time from the structural demands of white supremacy.
Exchange-traded Funds in India Amid COVID-19 Crisis: An Empirical Analysis of the Performance
Authors: Malhotra Priya , Sinha Pankaj 
Published: January 2023

Since their inception in 2002, exchange-traded funds (ETFs) in India have made significant progress. The lacklustre record of active investing and the dual benefits of low-cost diversification have elevated the asset class’s credibility. During the COVID-19 crisis, equities ETFs have demonstrated greater resilience than other investment options. Our examination of 35 ETFs that mirror broader indices indicates the performance of Indian ETFs amid the economic shock caused by COVID-19. A comprehensive analysis of the daily NAV, trading price, and benchmark price data from 2015 to the present, post-identification of the pandemic period, indicates three significant inferences: First, tracking errors persist, with significant increases in all three tracking measures throughout the COVID-19 period. Second, during the COVID-19 period, the existence of pricing inefficiencies transitions from discount to premium, with an average daily value of 57.485. Nonetheless, the rate of short-term disequilibrium corrections accelerates dramatically during the COVID-19 phase. Thirdly, it took only eight days during COVID-19 to erase 50% of the disequilibrium between NAV and market price, compared to 170 days before COVID-19. During the COVID-19 era, we also notice a rise in the co-integration between ETF returns and benchmark performance and an increase in the adjustment rate from 18% to 61% per unit of time. The research findings provide portfolio managers and regulators with a comprehensive view of the performance of ETFs before and after an economic shock and offer educational benefits to a growing investor base.
The Relationship Between Uterine Activity, Oxytocin Dosing, Labor Progress, and Mode of Birth in Nulliparas with Obesity: Minimal Usefulness of Montevideo Unit Measurement
Authors: Kissler Katherine J. , Hernandez Teri L. , Carlson Nicole 
Published: January 2023

Background Maternal obesity and cesarean birth disproportionately affect Black parturients; thus, prevention of cesarean birth is a key modifiable factor to improve pregnancy outcomes and reduce disparities. The primary driver of unplanned cesarean birth among people with higher body mass index is prolonged labor duration. However, strategies to optimize outcomes in these situations have not been established. We aimed to evaluate the influence of oxytocin augmentation on uterine activity and labor progression in nulliparas with obesity. Methods This secondary analysis involved nulliparas with obesity (BMI ≥30 kg/m2) who had spontaneous labor onset followed by oxytocin augmentation and an intrauterine pressure catheter. Using Linear Mixed Models, we evaluated relationships between uterine activity measured in Montevideo units (MVU), oxytocin dose, and rate of cervical dilation normalized by labor duration. Results In this diverse sample (35.6% Caucasian, 16.11% African American, 40.2% Hispanic) of nulliparas with obesity ( n = 87; BMI 35.54 ± 4.38 kg/m2), 31% ended labor with cesarean birth. Among those with vaginal birth, only 13% had MVU ≥200 prior to the final 2 hours of labor. MVUs were only minimally responsive to oxytocin dose and were not associated with labor progression nor birth route. Conclusion MVU measurements may not be useful to diagnose labor arrest in nulliparas with obesity. Optimizing care for birthing people with obesity is essential for improving perinatal outcomes and for reducing racial health disparities.
A decade of arteriovenous fistula creations in the ⩾75 years population: Equal opportunity or sub-optimal use of resources
Authors: Corr Michael , Pachchigar Astha , O’Neill Michael , Higgins Rebecca , O’Neill Stephen , Hanko Jennifer , Masengu Agnes 
Published: January 2023

Background: The optimal vascular access in the elderly remains contentious in the context of increasingly limited resources and anticipated survival on hemodialysis. Research focus has shifted to include the impact of vascular access on quality of life. This study explored clinical outcomes in individuals aged ⩾75 years who had an arteriovenous fistula (AVF) created in a single center over a 10-year period. Materials and methods: Demographic and clinical data concerning AVFs created January 2009–December 2019 were identified from a prospective database for retrospective analysis. Outcome measures were AVF patency and failure to mature rates plus overall patient and vascular access survival. The Vascular Access Specific Quality of life measure (VASQoL) was completed in a contemporary cohort aged ⩾75 years established on HD in October 2021. Results: AVF outcomes were available for 272 patients (93%). The failure to mature (FTM) rate was 36% with the significant predictors of AVF FTM being the creation of a radiocephalic AVF (OR 8.13, 95% CI 8.02–8.52, p < 0.01), female gender (OR 4.84, 95% CI 4.70–5.41, p < 0.01), and a history of peripheral vascular disease (OR 5.25, 95% CI 5.22–6.00, p value = 0.02). Functional patency was associated with a median 12-month survival benefit compared to those whose fistula FTM ( p < 0.01). The median patency duration for a functionally patent AVF was 3 years. Elderly patients with a fistula reported a lower quality of life in VASQoL scoring than those with central venous catheters. Conclusions: In this cohort, AVF creation in individuals aged ⩾75 years AVFs was associated with comparable AVF patency rates to younger patients. AVF functional patency was associated with superior patient survival compared to those with AVF FTM. A multi-disciplinary surveillance program may help reduce AVF loss. Further work on how vascular access choice impacts quality of life in elderly patients is required.