bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of a PD1/PD‐L1 inhibitor by structure‐based pharmacophore modelling, virtual screening, molecular docking and biological evaluation**
Authors: Choorakottayil Pushkaran Anju , K Kumaran , T Ann Maria , Biswas Raja , Mohan C. Gopi 
Published: March 2023

AbstractPD‐1/PD‐L1 is a critical druggable target for immunotherapy against sepsis. Chemoinformatics techniques involved the structure‐based 3D pharmacophore model development followed by virtual screening of small molecule databases to identify the small molecules against PD‐L1 pathway inhibition. Raltitrexed and Safinamide act as potent repurposed drugs, and three other Specs database compounds using in silico methods. These compounds were screened based on the pharmacophore fit score and binding affinity towards the active site of the PD‐L1 protein. In silico pharmacokinetic profiling of these screened compounds was done to test their biological activity. Next, experimental validation of the best four virtually screened hits was done in vitro for its hemocompatibility and cytotoxicity. Among these, Raltitrexed, Safinamide and Specs compound (AK‐968/40642641) effectively increased the proliferation of immune cells and IFN‐γ production. These compounds can act as potent PDL‐1 inhibitors for adjuvant therapy against sepsis.
Nursing managers' experiences of facing the COVID‐19 pandemic in their work: A systematic review
Authors: Leppäkoski Tuija , Mattila Elina , Kaunonen Marja 
Published: March 2023

AbstractAimThere is far little evidence available on nursing managers' experiences during this global crisis. This systematic review aimed to provide the first comprehensive summary of the findings of published studies describing data concerning nursing managers' experiences of the COVID‐19 outbreak.DesignStudies published between January 2019 and the end of December 2021 were retrieved from CINAHL, Medline and PubMed databases. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement was used to guide the search methodology.MethodsIn total, 14 relevant articles were assessed using the Joanna Briggs Institute Critical Appraisal Tools and subjected to thematic content analysis.ResultsOur findings revealed five main themes describing nursing managers' experiences: an expanding and changing role, ensuring the well‐being of staff, communication, support received, development and learning. Nursing managers found the task of operational management confusing, as objectives have been constantly changing as the pandemic has progressed. The results should be used in preparation for future crises similar to the COVID‐19 pandemic.
The religious self‐alteration of Shem Irofa'alu during the anti‐colonial Maasina Rule in Solomon Islands (1944–1953)
Authors: Timmer Jaap , Frazer Ian 
Published: March 2023

AbstractThis essay explores the post‐World War Two anti‐colonial Maasina Rule in north Malaita, Solomon Islands, to show how a church leader Shem Irofa'alu decided to establish a religious movement independent of the state and the traditional evangelical church. Irofa'alu's movement indexes an important moment of culture change towards increasing enthusiasm for the often‐overlooked Christianity‐based forms of sovereignty in the region. It highlights that Maasina Rule was not only a powerful rupture in social processes, but also sharpened the growing division between state and church. Irofa'alu's role in Maasina Rule shows that his influence peaked between 1948 and 1950 and then went into rapid decline. This change in fortune coincided with a critical turning point in the colonial government's attempts to end the movement through appeasement. No longer the head of the evangelical church in Malu'u sub‐district and frustrated about the mother church's governance, Irofa'alu retreated to his home area and set about establishing a new church, Boboa (‘Foundation’), his first attempt at organizing a self‐governing assembly before introducing Jehovah's Witnesses in north Malaita. In later years, Irofa'alu became a prophet‐exemplar for new generations of religious leaders trying to establish Malaitan sovereignties based on their own power to move the truth of prophecies away from foreign state and church organizations.
Polyimide and polystyrene‐based activated carbon nanofibers with tubular structure for supercapacitor
Authors: Weng Xin , Wang Zhenzhen , Zhang Bing , Yu Xiaodong , Liu Xia , He Tieshi 
Published: March 2023

AbstractPolyimide (PI) and polystyrene (PS) blend electrospun fibers are prepared by electrospinning method. PI and PS are not completely compatible due to the difference of solubility and surface energy in electrospinning precursor, so PI/PS electrospun fibers have some phase separations along the electric field direction under the high‐voltage electrostatic force. PI with high carbon conversion served as carbon nanofibers, PS with low carbon conversion served as porogenic sacrificial agent, so PI/PS‐based activated carbon nanofibers derived from PI/PS electrospun fibers with well‐controlled opening tubular structure are obtained via thermally induced phase separation process. The morphology and electrochemical performance of activated carbon nanofibers are investigated by structural analysis and electrochemical measurements. The relationships among pores structure, electrolyte character and electrochemical performance of activated carbon fibers are extensively evaluated. Activated carbon nanofibers derived from PI/PS (mass ratio = 1:2) electrospun fibers with nano scale opening tube wall structure show a small charge transfer resistance and the short electric double layers forming time, but also suitable average pore diameter (3.74 nm), high BET specific surface area (952.5 m2 g−1) and average pore volume (0.532 cm3 g−1). Then, a comprehensive electrochemical performance can also be achieved in organic electrolyte: high energy density (31.80 Wh kg−1), good power density (3094.05 W kg−1) and low internal resistance (1.24 Ω). The findings reveal a guideline for the preparation of polymer‐based hierachical porous and opening tubular structure activated carbon nanofibers for electrochemical energy conversion and storage devices.
Evidence for the use of curcumin in radioprotection and radiosensitization
Authors: Boretti Alberto 
Published: March 2023

AbstractCurcumin has antineoplastic properties and is considered a chemotherapeutic and chemopreventive agent. Curcumin may be associated with radiation therapy (RT) as a radiosensitizer for cancer cells and a radioprotector for normal cells. In principle, it may result in a reduction of RT dosage for the same therapeutic effect on cancer cells, and further reduced damage to normal cells. Though the overall level of evidence is modest, limited to in vivo and in vitro experiences and practically no clinical trials, as the risks of adverse effects are extremely low, it is reasonable to promote the general supplementation with curcumin during RT targeting the reduction of side effects through anti‐inflammatory mechanisms.
Linking SVM based habitat model and evolutionary optimisation for managing environmental impacts of hydropower plants
Authors: Sedighkia Mahdi , Datta Bithin 
Published: March 2023

AbstractThe present study proposes a support vector machine (SVM)‐based habitat model linked with evolutionary optimisation to balance the impacts of generating hydropower on the downstream river habitats. This method was applied in the Rajaei reservoir and Tajan River basin in Iran to mitigate the environmental impacts of hydropower plants. SVM model classified the habitat suitability at downstream river in which a sigmoid function considering different slopes was applied. The Nash–Sutcliffe efficiency coefficient as the evaluation index of the habitat model is 0.8, which implies the SVM model is robust to simulate physical habitats. Hydraulic simulation demonstrated that depth and velocity change from zero to 1.79 m and zero to 1.82 m/s, respectively. Most suitable river flow is 7 m3/s downstream of Rajaei reservoir. Five evolutionary algorithms were used to balance environmental impacts with generating hydropower. Finally, a fuzzy technique for order of preference by similarity to ideal solution (FTOPSIS) selected the best optimal solution in the Rajaei reservoir. Based on optimisation results, The simulated annealing (SA) algorithm was the best optimisation method to balance generating hydropower and downstream ecological impacts, in which average habitat suitability is more than 90% of average habitat suitability in the natural flow, while reliability of generating hydropower is 38%. Moreover, SA is able to minimise the average difference between habitat suitability in the optimal release and the natural flow properly. Using the proposed method is recommendable to mitigate the potential impacts of generating hydropower on the downstream river habitats.
Enzyme‐Catalyzed Synthesis, Odor Characteristics and Thermal Analysis of New Pyridine Esters
Authors: Zhao Qianrui , Wang Longxin , Chen Haoran , Wu Zhiyong , Zhao Mingqin , Lai Miao 
Published: March 2023

AbstractA new method for the efficient conversion of pyridine methanols and ethyl carboxylates to pyridine esters in air catalyzed by Novozym 435 (N435) was reported. The enzyme catalyzed transesterification reaction was performed under the optimum conditions: N435 (60 mg) as a biocatalyst, acetonitrile (2.5 mL) as a solvent, the molar ratio of pyridine methanols (0.2 mmol) to ethyl carboxylats (1.0 mmol) of 1 : 5, molecular sieve 3 A of 1.00 g, reaction temperature of 50 °C, the revolution speed of 150 rpm and reaction time of 36 h. The enzyme still retained a yield of 80 % after repeated use for 10 times. Under optimal conditions, eighteen pyridine esters were synthesized in this paper, containing fifteen esters as novel compounds. The synthesized pyridine esters were analyzed by gas chromatography‐mass spectrometry‐olfactory (GC‐MS‐O), of which four pyridyl esters including compounds 3 a, 3 c, 3 g and 3 r possessed strong aromas which were based on peak area in GC‐MS. Thermogravimetric analysis (TG) was performed on these four flavor compounds. According to the results of TG analysis, they had good thermal stability at the certain temperature.
Spherically Structured Ce‐Metal‐Organic Frameworks with Rough Surfaces and Carbon‐Coated Cerium Oxide as Potential Electrodes for Lithium Storage and Supercapacitors
Authors: Kumaresan Lakshmanan , Hanamantrao Desai Prashant , Raj S L Sajan , Chenrayan Senthil , Rangasamy Baskaran , Vediappan Kumaran 
Published: March 2023

AbstractThe rough spherical‐shaped cerium metal‐organic framework (Ce‐MOF) is synthesized by using solvothermal technique, and after being calcined at 550 °C both with and without tannic acid, CeO2 and C@CeO2 are produced. As synthesized Ce‐MOF, CeO2, and C@CeO2 are constructed as anodes for lithium‐ion batteries (LIBs), also Ce‐MOF and C@CeO2 are investigated for use in supercapacitors. In the case of LIBs, as anode, C@CeO2 exhibits a good reversible discharge capacity of 137 mAh g−1 with 99 % coulombic efficiency over 250 cycles at 1 C rate. It demonstrates that the conductivity is greatly improved by the carbon covering than the pristine CeO2 and Ce‐MOF. After the galvanostatic charge‐ discharge technique at 1 C rate, the morphology size was investigated using FESEM to conform further the following alloying and dealloying mechanism of C@CeO2 and the dissolution of terephthalic acid (TPA) in the non‐aqueous electrolyte that is connected to the core structure of Ce‐MOF. In terms of supercapacitors, rough surface morphology improves the electrode electrolyte conduct also the ligand TPA of free terminal acid group attracting K+ and forms the COO− K+. Thus, Ce‐MOF exhibits a good specific capacitance; after 5000 cycles, it produces 118 F g−1 at 4 A g−1.with 65.2 % capacitance retention. The archived maximum power and energy density outcomes of 10.6 kW kg−1 and 0.56 Wh kg−1 at 2 A g−1.
An Ion‐imprinted Polymer‐Receptor‐Based Electrochemical Sensor for the Sensitive and Selective Detection of Cadmium
Authors: Sadiq Nauman , Shafique Muhammad , Akbar Muafia , Shakoor Memoona , Mujahid Adnan , Hussain Tajamal , Mustafa Ghulam 
Published: March 2023

AbstractIn this research work, an ion‐imprinted polymer based electrochemical sensor developed for the sensitive and selective detection of cadmium ions in water. Ion‐imprinted and non‐imprinted polymers were synthesized by thermal free‐radical bulk polymerization. Monomer to crosslinker ratio was optimized receptors chemistry and morphology were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Receptors were coated onto interdigital electrodes (IDEs) by spin coating and sensor parameters such as sensitivity, selectivity and reversibility were evaluated by using LCR meter. The fabricated sensor showed concentration dependent linear response with limit of detection of 103 ppb. Selectivity was analyzed in the presence of interfering ions such as Zn2+, Hg2+, Cu2+ and Pb2+. The sensor showed a highly selective and reversible response towards cadmium ions.
Splashing‐Assisted Femtosecond Laser‐Activated Metal Deposition for Mold‐ and Mask‐Free Fabrication of Robust Microstructured Electrodes for Flexible Pressure Sensors
Authors: Ji Yaqiang , Zhang Yuan , Zhu Jiaqi , Geng Pai , Halpert Jonathan E. , Guo Liang 
Published: March 2023

AbstractFlexible pressure sensors play an indispensable role in flexible electronics. Microstructures on flexible electrodes have been proven to be effective in improving the sensitivity of pressure sensors. However, it remains a challenge to develop such microstructured flexible electrodes in a convenient way. Inspired by splashed particles from laser processing, herein, a method for customizing microstructured flexible electrodes by femtosecond laser‐activated metal deposition is proposed. It takes advantage of the catalyzing particles scattered during femtosecond laser ablation and is particularly suitable for moldless, maskless, and low‐cost fabrication of microstructured metal layers on polydimethylsiloxane (PDMS). Robust bonding at the PDMS/Cu interface is evidenced by the scotch tape test and the duration test over 10 000 bending cycles. Benefiting from the firm interface, the developed flexible capacitive pressure sensor with microstructured electrodes presents several conspicuous features, including a sensitivity (0.22 kPa−1) 73 times higher than the one using flat Cu electrodes, ultralow detection limit (<1 Pa), rapid response/recovery time (4.2/5.3 ms), and excellent stability. Moreover, the proposed method, inheriting the merits of laser direct writing, is capable of fabricating a pressure sensor array in a maskless manner for spatial pressure mapping.
Understanding and Optimizing Capacitance Performance in Reduced Graphene‐Oxide Based Supercapacitors
Authors: Gadipelli Srinivas , Guo Jian , Li Zhuangnan , Howard Christopher A. , Liang Yini , Zhang Hong , Shearing Paul R. , Brett Dan J. L. 
Published: March 2023

AbstractReduced graphene‐oxide (RGO)‐based electrodes in supercapacitors deliver high energy/power capacities compared to typical nanoporous carbon materials. However, extensive critical analysis of literature reveals enormous discrepancies (up to 250 F g−1) in the reported capacitance (variation of 100–350 F g−1) of RGO materials synthesized under seemingly similar methods, inhibiting an understanding of capacitance variation. Here, the key factors that control the capacitance performance of RGO electrodes are demonstrated by analyzing and optimizing various types of commonly applied electrode fabrication methods. Beyond usual data acquisition parameters and oxidation/reduction properties of RGO, a substantial difference of more than 100% in capacitance values (with change from 190 ± 20 to 340 ± 10 F g−1) is found depending on the electrode preparation method. For this demonstration, ≈40 RGO‐based electrodes are fabricated from numerous distinctly different RGO materials via typically applied methods of solution (aqueous and organic) casting and compressed powders. The influence of data acquisition conditions and capacitance estimation practices are also discussed. Furthermore, by optimizing electrode processing method, a direct surface area governed capacitance relationship for RGO structures is revealed.
Teach an old dog new tricks: Meningoencephalitis of unknown origin (MUO) in Australian shepherd dogs
Authors: Kajin Filip , Schuwerk Lukas , Beineke Andreas , Volk Holger A. , Meyerhoff Nina , Nessler Jasmin 
Published: March 2023

AbstractMeningoencephalitis of unknown origin is mostly considered a disease of young small dogs and terrier breeds, while older dogs presenting with clinical signs of deteriorating encephalopathy are more commonly diagnosed with intracranial neoplasia. In this case series, three Australian shepherd dogs, 7, 10 and 11 years old, were diagnosed with meningoencephalitis of unknown origin; with serial magnetic resonance imaging in two dogs and postmortem examination in one dog. Follow‐up magnetic resonance imaging examination after 4 months showed complete resolution of magnetic resonance imaging abnormalities in one dog treated with prednisolone. The other dog had a recurrence of clinical signs and multifocal de novo lesions noted in magnetic resonance imaging done at 23 months after diagnosis and tapering of prednisolone. In older dogs, a diagnosis of intracranial neoplasia should not be assumed based on clinical signs of deteriorating encephalopathy alone, and meningoencephalitis of unknown origin should be on the differential list. Older dogs diagnosed with meningoencephalitis of unknown origin can have good outcomes with immunomodulatory therapy.
Projections of synoptic anticyclones for the twenty-first century
Authors: Pepler Acacia 
Published: March 2023

AbstractSynoptic anticyclones are a common feature of subtropical and midlatitude climate and are associated with descending air and clear conditions, while associated anticyclonic circulation anomalies can contribute to temperature extremes. When anticyclones are tracked in both the ERA5 reanalysis and 10 global climate models from the 5th Coupled Model Intercomparison Project (CMIP5) using a common grid, the CMIP5 models consistently underestimate the observed frequency of anticyclones in the southern hemisphere, while overestimating anticyclone frequencies in the northern hemisphere. Under a high emissions scenario, the overall frequency of anticyclones is projected to decline over the twenty-first century. Declines are largest in the southern hemisphere subtropics, where projected changes in anticyclone frequency can be linked to the projected poleward shift in the Southern Annular Mode. Stronger and more robust declines are projected for the subset of quasi-stationary anticyclones that move less than 4° over 24 h. Using the Australian region as a case study, regionally downscaled models show very similar projected changes to the driving CMIP5 models, adding little additional value for understanding projected changes in anticyclones.
Colorism in the Indian subcontinent—insights through situated affectivity
Authors: Bajwa Marium Javaid , von Maur Imke , Stephan Achim 
Published: March 2023

AbstractConsistent discriminatory practices associated with dark and black skin color underpin the persistence of colorism and racism in the Indian subcontinent. To understand better how skin color ideologies occupy the mind of people with the effect of marginalizing those with dark skin color and promoting whiteness as a social capital, we will apply the paradigm of situated affectivity. The conceptual tools developed in this framework will help to see how the environmental structures that perpetuate colorism have a pervasive influence on individuals’ values and their emotional repertoire from a very young age. After having documented how the minds of individuals are invaded with discriminatory colorist positions, we will present how people indulge in processes of user-resource interactions assumed to help regulating their affect, that in turn, result in re-enforcing again colorist and racist ideologies and practices.
Potential Factors Associated with the Blood Metal Concentrations of Reproductive-Age Women in Taiwan
Authors: Ying Tsung-Ho , Huang Chun-Jui , Hsieh Chia-Jung , Wu Pei-Ju , Yeh Chang-Ching , Hung Ping-Kun , Chang Wei-Hsiang , Wu Meng-Hsing , Hung Hsin , Chang Jung-Wei , Wang Chen-Tai , Arcega Rachelle D. , Mahmudiono Trias , Lee Ching-Chang , Chen Hsiu-Ling 
Published: March 2023

AbstractExposure of reproductive-age women to toxic trace elements warrants attention because of their negative effects. This study aimed to investigate the levels of arsenic (As), cadmium (Cd), mercury (Hg), chromium (Cr), and lead (Pb) in the blood of 837 Taiwanese childbearing-age women and establish the correlation between their dietary pattern and heavy metal concentration. The concentrations of Cd and Pb were significantly higher in nonpregnant women than in pregnant women (Cd: 2.41 µg/L vs. 2.12 µg/L; Pb: 0.83 µg/dL vs. 0.73 µg/dL), whereas the concentration of Cr was significantly lower in nonpregnant women than in pregnant women (Cr: 0.98 µg/L vs. 1.05 µg/L). Otherwise, no significant differences in As (9.02 µg/L vs. 9.51 µg/L) and Hg (3.71 µg/L vs. 3.79 µg/L) were found between the nonpregnant and pregnant women. Overall, the blood metal concentrations of Cd and Hg showed a decreasing trend in the different pregnancy stages. The levels of As and Hg were highly correlated with seafood intake. Finally, lifestyle habits, such as burning incense usage and Chinese herb intake may contribute to metal accumulation in maternal or reproductive-age women. Preventive risk communication and educational strategies should be applied to these subgroups in view of food safety and public health concern.
Graphical Abstract