bluuebunny/crossref_metadata_2025_split huggingface dataset:
A ferritin protein is involved in the development and reproduction of the whitefly, Bemisia tabaci
Authors: Yu Hao , Wang Kui , Yang Zhifang , Li Xiang , Liu Shunxiao , Wang Liuhao , Zhang Hongwei 
Published: June 2023

Abstract
Ferritins are conserved iron-binding proteins that exist in most living organisms and play an essential role in the maintenance of cellular iron homeostasis. Although ferritin has been studied in many species, little is known about its role in the whitefly, Bemisia tabaci. In this study, we identified an iron-binding protein from B. tabaci and named it BtabFer1. The full-length cDNA of BtabFer1 is 1,043 bp and encodes a protein consisting of 224 amino acids with a deduced molecular weight of 25.26 kDa, and phylogenetic analysis shows that BtabFer1 is conserved among Hemiptera insects. The expression levels of BtabFer1 in different developmental stages and tissues were analyzed by real-time PCR, and results showed that BtabFer1 was ubiquitously expressed at all developmental stages and in all examined tissues. The RNAi-mediated knockdown of BtabFer1 caused a significant reduction in survival rate, egg production, and egg hatching rate of whiteflies. Knockdown of BtabFer1 also inhibited the transcription of genes in the juvenile hormone signal transduction pathway. Taken together, these results suggest that BtabFer1 plays a critical role in the development and reproduction of whiteflies. This study can broaden our understanding of ferritin in insect fecundity and development, as well as provide baseline data for future studies.
Listening at the edge of the line
Authors: Gorji Mina 
Published: June 2023

Abstract
To be listening, according to Jean-Luc Nancy, is ‘is always to be on the edge of meaning’. How do we listen to a poem’s edge? To the end of the line? This essay thinks about line endings and how they invite our listening. It explores the acoustics, dynamics, and somatic experience of line endings in the works of a number of poets, including Alice Oswald, Kathleen Jamie, William Wordsworth, and Jen Hadfield. It draws on Nancy, Denise Levertov, and Rita Dove’s thinking about line endings, and offers a series of amplified close-listenings which open up wider thinking about how we read and experience poetry. This is part of a larger exploration of what it means to listen to a poem — to the sounds a poem remembers, to the sounds a poem makes — on the page, in the air, in the ear — but also to the spaces, to the gaps and pauses, to the white space at the end of a line.
Pharmacist interventions in medication adherence in patients with mental health disorders: a scoping review
Authors: Syrnyk Matthew , Glass Beverley 
Published: June 2023

Abstract

Objective
Mental health patients struggle with medication adherence, providing opportunities for pharmacists to have a critical role in implementing key interventions for this patient cohort. This scoping review aimed to identify and evaluate evidence of pharmacists’ involvement in medication adherence interventions in mental health patients.

Methods
Three databases were searched from January 2013 to August 2022: PubMed, Embase and CINAHL. The first author independently performed screening and data extraction. Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR) was utilized to report this review. Themes related to the pharmacist’s role in improving medication adherence for mental health patients were identified and the strengths and weaknesses of these studies were evaluated.

Key Findings
A total of 3476 studies were identified and 11 studies met the selection criteria. Study types included retrospective cohort studies, quality improvement projects, observational studies, impact studies, service evaluations and longitudinal studies. Pharmacists worked primarily in community pharmacies, hospitals, or interdisciplinary mental health clinics, and improved medication adherence within these settings, at transitions of care, and by utilizing digital health. The patient perspective was valuable in identifying barriers and enablers to medication adherence. Pharmacists had varying levels of education and training, with studies highlighting the importance of completing extended training programs and partaking in expanded roles such as pharmacist prescribing.

Conclusions
This review highlighted the need for expanded pharmacist roles within multidisciplinary mental health clinics and further training in psychiatric pharmacotherapy, to aid pharmacists in confidently improving medication adherence for mental health patients.
On the stability of totally upwind schemes for the hyperbolic initial boundary value problem
Authors: Boutin Benjamin , Le Barbenchon Pierre , Seguin Nicolas 
Published: June 2023

Abstract
In this paper, we present a numerical strategy to check the strong stability (or GKS-stability) of one-step explicit totally upwind schemes in 1D with numerical boundary conditions. The underlying approximated continuous problem is the one-dimensional advection equation. The strong stability is studied using the Kreiss–Lopatinskii theory. We introduce a new tool, the intrinsic Kreiss–Lopatinskii determinant, which possesses remarkable regularity properties. By applying standard results of complex analysis, we are able to relate the strong stability of numerical schemes to the computation of a winding number, which is robust and cheap. The study is illustrated with the Beam–Warming scheme together with the simplified inverse Lax–Wendroff procedure at the boundary.
Human Rights beyond the Liberal Script: A Morphological Approach
Authors: Berger Tobias 
Published: June 2023

Abstract
While recent scholarship has turned to the increasing fragmentation of global human rights discourses, the often competing ideological projects in which different understandings of human rights are embedded have received comparatively scant attention. Instead, human rights are treated as isolated norms. Although treated as isolated, human rights norms are frequently simultaneously understood against the implicit backdrop of liberal assumptions about political order and human agency, thereby obscuring alternative human rights conceptions. This research note seeks to move our understanding of human rights beyond the liberal script. Drawing on advances in the fields of intellectual history and political theory, it develops a morphological approach that treats norms not only as individual standards of appropriate behavior but as complex units of meanings. These meanings only emerge in larger ideational formations in which varying notions of human rights are temporarily fixed through their positioning toward other concepts. This morphological understanding of human rights as part of larger conceptual arrangements allows for their analysis beyond the liberal script as the research note shows by way of two illustrative case studies, which focus on human rights beyond liberal notions of democracy and the rule of law as well as beyond the human as ontologically singular.
Physiological roles and regulation of hepatic angiopoietin-like protein 3 in Japanese Black cattle (Bos taurus) during the fattening period
Authors: Shikida Rika , Kim Minji , Futohashi Makoto , Nishihara Koki , Lee Huseong , Suzuki Yutaka , Baek Yeolchang , Masaki Tatsunori , Ikuta Kentaro , Iwamoto Eiji , Uemoto Yoshinobu , Haga Satoshi , Terada Fuminori , Roh Sanggun 
Published: June 2023

Abstract
Angiopoietin-like protein 3 (ANGPTL3) is expressed predominantly in the liver and plays a major role in regulating the circulating triglyceride and lipoprotein fraction concentrations by inhibiting lipoprotein lipase (LPL) activity. Given these physiological roles, ANGPTL3 may play an important role in metabolic changes related to fat accumulation during the fattening period in Japanese Black. This study aimed to reveal the physiological roles of hepatic ANGPTL3 in Japanese Black steers (Bos taurus) during the fattening period and investigate the regulatory effects of hepatic ANGPTL3. To investigate the gene expression and protein localization of ANGPTL3, 18 tissue samples were collected from tree male Holstein bull calves aged 7 wk. Biopsied liver tissues and blood samples were collected from 21 Japanese Black steers during the early (T1; 13 mo of age), middle (T2; 20 mo), and late fattening phases (T3; 28 mo). Relative mRNA expression, blood metabolite concentrations, hormone concentrations, growth, and carcass traits were analyzed. To identify the regulatory factors of hepatic ANGPTL3, primary bovine hepatocytes collected by two Holstein calves aged 7 wk were incubated with insulin, palmitate, oleate, propionate, acetate, or beta-hydroxybutyric acid (BHBA). The ANGPTL3 gene was most highly expressed in the liver, with minor expression in the renal cortex, lungs, reticulum, and jejunum in Holstein bull calves. In Japanese Black steers, relative ANGPTL3 mRNA expressions were less as fattening progressed, and blood triglyceride, total cholesterol, and nonesterified fatty acid (NEFA) concentrations increased. Relative ANGPTL8 and Liver X receptor alpha (LXRα) mRNA expressions decreased in late and middle fattening phases, respectively. Furthermore, relative ANGTPL3 mRNA expression was positively correlated with ANGPTL8 (r = 0.650; P &lt; 0.01) and ANGPTL4 (r = 0.540; P &lt; 0.05) in T3 and T1, respectively, and LXRα showed no correlation with ANGPTL3. Relative ANGTPL3 mRNA expression was negatively correlated with total cholesterol (r = −0.434; P &lt; 0.05) and triglyceride (r = −0.645; P &lt; 0.01) concentrations in T3 and T1, respectively; There was no significant correlation between ANGTPL3 and carcass traits. Relative ANGTPL3 mRNA expression in cultured bovine hepatocytes was downregulated in oleate treatment. Together, these findings suggest that ANGPTL3 downregulation in late fattening phases is associated with the changes in lipid metabolism.
‘Doing’ legal history in refugee law: A snapshot of Bangladesh’s engagement with non-refoulement
Authors: Hossain M Sanjeeb 
Published: June 2023

Abstract
This article advocates for the adoption of legal history in the study of refugee law and associated legal scholarship. It begins by illustrating the meaning and value of legal history by sifting through the texts introducing the inaugural issues of some of the world’s most reputed legal history journals. It asks what makes a good legal historian and highlights the impossibility of attaining total objectivity when producing historical work. The article then sheds light on archival research and oral history as essential tools for doing legal history but cautions against being swayed by arrogant claims that the application of such empiricist and contextualist methods produces impartial legal history. Finally, the article demonstrates the value of doing legal history in refugee law by offering a snapshot of Bangladesh’s engagement with non-refoulement in the late 1970s when mass displacements of the Rohingya people from Myanmar and Indian Muslims from India took place.
Robust estimation and inference for expected shortfall regression with many regressors
Authors: He Xuming , Tan Kean Ming , Zhou Wen-Xin 
Published: June 2023

Abstract
Expected shortfall (ES), also known as superquantile or conditional value-at-risk, is an important measure in risk analysis and stochastic optimisation and has applications beyond these fields. In finance, it refers to the conditional expected return of an asset given that the return is below some quantile of its distribution. In this paper, we consider a joint regression framework recently proposed to model the quantile and ES of a response variable simultaneously, given a set of covariates. The current state-of-the-art approach to this problem involves minimising a non-differentiable and non-convex joint loss function, which poses numerical challenges and limits its applicability to large-scale data. Motivated by the idea of using Neyman-orthogonal scores to reduce sensitivity to nuisance parameters, we propose a statistically robust and computationally efficient two-step procedure for fitting joint quantile and ES regression models that can handle highly skewed and heavy-tailed data. We establish explicit non-asymptotic bounds on estimation and Gaussian approximation errors that lay the foundation for statistical inference, even with increasing covariate dimensions. Finally, through numerical experiments and two data applications, we demonstrate that our approach well balances robustness, statistical, and numerical efficiencies for expected shortfall regression.
A parametric competing risks regression model with unknown dependent censoring
Authors: Lo Simon M S , Wilke Ralf A 
Published: June 2023

Abstract
A typical situation in survival analysis is that there is only interest in one risk and some prior information about its distribution is available. At the same time, other risks are not of interest and no information about risk dependence is available. A parametric regression model with unknown dependent censoring would be suitable here, but existing approaches require restrictions on all marginal survivals, the censoring distribution or the degree of dependence. This article introduces a model without these restrictions. An application to employment duration demonstrates that it avoids sizable bias of the estimated gender effect on employment duration.
Acute withdrawal in the postoperative setting in a patient taking standard therapeutic doses of pregabalin
Authors: Kulig Caitlin E , Hooda Zamaan , Lebow Elissa , Cerda Luis , Zaku Bledi 
Published: June 2023

Abstract
Pregabalin is a gamma-aminobutyric acid analog that binds to voltage-gated calcium channels within the central nervous tissues, inhibiting the release of many excitatory neurotransmitters. It is used to treat various conditions including postherpetic neuralgia and diabetic peripheral neuropathy. Recently, its use has increased as part of non-opioid pain management algorithms. Prolonged use in high doses of pregabalin is associated with physical dependency and abuse, which can be seen when the medication is abruptly stopped. This phenomenon has been seen in studies focused on patients having abused or grown dependent on pregabalin. However, this has not been documented in patients taking therapeutic levels in the perioperative setting. This case report highlights a patient who experienced acute withdrawal symptoms of pregabalin after coronary artery bypass and aortic root enlargement.
A donation list from Elephantine: Judaean and Non-Judaean onomastic characteristics from the Persian period in Egypt
Authors: Golub Mitka R 
Published: June 2023

Abstract
This study uses quantitative methods in the analysis and comparison of 195 names on a donation list from the Nile island of Elephantine, dated to 400 bce, with Judaean names from the end of the First Temple period. The goal is to shed more light on the origin of the individuals named on the list and their relationship, if any, to Judaeans. The onomastic analysis is based on the distributions of name types, theophoric elements and prefixed/suffixed theophoric elements, as well as on the most popular roots in names and the prevalence of names common to the donors and Judaeans. The results revealed several Judaean onomastic characteristics in Elephantine that help support the claim that the origin of these Elephantine donors is Judaean. At the same time, other onomastic characteristics which differ from those in Judah may be attributed to the influence of the surrounding multi-cultural society, as well as the time gap between the donors and Judaeans.
Role of Strigolactones in the Host Specificity of Broomrapes and Witchweeds
Authors: Huizinga Sjors , Bouwmeester Harro J 
Published: June 2023

AbstractRoot parasitic plants of the Orobanchaceae, broomrapes and witchweeds, pose a severe problem to agriculture in Europe, Asia and especially Africa. These parasites are totally dependent on their host for survival, and therefore, their germination is tightly regulated by host presence. Indeed, their seeds remain dormant in the soil until a host root is detected through compounds called germination stimulants. Strigolactones (SLs) are the most important class of germination stimulants. They play an important role in planta as a phytohormone and, upon exudation from the root, function in the recruitment of symbiotic arbuscular mycorrhizal fungi. Plants exude mixtures of various different SLs, possibly to evade detection by these parasites and still recruit symbionts. Vice versa, parasitic plants must only respond to the SL composition that is exuded by their host, or else risk germination in the presence of non-hosts. Therefore, parasitic plants have evolved an entire clade of SL receptors, called HTL/KAI2s, to perceive the SL cues. It has been demonstrated that these receptors each have a distinct sensitivity and specificity to the different known SLs, which possibly allows them to recognize the SL-blend characteristic of their host. In this review, we will discuss the molecular basis of SL sensitivity and specificity in these parasitic plants through HTL/KAI2s and review the evidence that these receptors contribute to host specificity of parasitic plants.
Acupuncture and its ability to restore and maintain immune homeostasis
Authors: Liu F , Wang Y , Lyu K , Du X , Zhou M , Shi J , Na R , Guo Y , Wang G , Xu W , Zheng T 
Published: June 2023

SummaryImmune homeostasis is a steady immune state that not only protects the host from pathogens but also prevents the emergence of pathological self-reactive immune cells. The disruption of immune homeostasis leads to the development of various diseases, such as cancer and autoimmune diseases. An emerging paradigm for the treatment of these diseases with dysfunctional immune systems is the restoration and maintenance of immune homeostasis. However, currently available drugs exert a unidirectional influence on immunity whereby they either augment or inhibit it. This strategy is associated with the drawback of potential adverse effects arising from uncontrolled activation or suppression of the immune system. Fortunately, evidence suggests that acupuncture can bidirectionally regulate the immune system to maintain immune homeostasis. In cases of immunosuppressive diseases (e.g. cancer), acupuncture has an enhancing effect on immunity. Conversely, in autoimmune diseases (e.g. rheumatoid arthritis), acupuncture has been observed to have an immunosuppressive effect, which helps restore normal immune tolerance. However, there is no publication systematically summarizing the bidirectional regulatory effects of acupuncture on the immune system in the literature. Here, our review provides a comprehensive overview of the various mechanisms through which acupuncture modulates the immune system in a bidirectional manner. These mechanisms include the augmentation of NK and CD8+ T cell function, as well as the restoration of Th1/Th2, Th17/Treg and M1/M2 balance. Thus, we propose the concept that acupuncture has the potential to alleviate illnesses through the facilitation of immune normalization. Moreover, we further highlight the therapeutic potential of acupuncture.
Hypoxic Preconditioning Enhances Cellular Viability and Migratory Ability: Role of DANCR/miR-656-3p/HIF-1α Axis in Placental Mesenchymal Stem Cells
Authors: Haoran Shi , Zhishan Jin , Yan Mao , Ruilin Ma , Jianjian Cui , Zejun Yang , Jianwen Zhu , Hui Gao , Yin Zhao 
Published: June 2023

Abstract
Preeclampsia (PE) is a common complication of pregnancy characterized by new-onset hypertension, albuminuria, or end-stage organ dysfunction, which is seriously harmful to maternal and infant health. Mesenchymal stem cells (MSCs) are pluripotent stem cells derived from extraembryonic mesoderm. They have the potential for self-renewal, multidirectional differentiation, immunomodulation, and tissue regeneration. Several in vivo and in vitro experiments have confirmed that MSCs can delay the pathological progression of PE and improve maternal and fetal outcomes. However, the major limitations in the application of MSCs are their low-survival rates in ischemic and hypoxic disease areas after transplantation and their low rate of successful migration to the diseased regions. Therefore, enhancing cell viability and migration ability of MSCs in both ischemic and anoxic environments is important. This study aimed to investigate the effects of hypoxic preconditioning on the viability and migration ability of placental mesenchymal stem cells (PMSCs) and their underlying mechanisms. In this study, we found that hypoxic preconditioning enhanced the viability and migration ability of PMSCs, increased the expression of DANCR and hypoxia-inducible factor-1α (HIF-1α), and decreased the expression of miR-656-3p in PMSCs. Inhibiting the expression of HIF-1α and DACNR in PMSCs under hypoxia can inhibit the promotive effect of hypoxic preconditioning on viability and migration ability. In addition, RNA pull down and double luciferase assays confirmed that miR-656-3p could directly bind to DANCR and HIF-1α. In conclusion, our study showed that hypoxia could promote the viability and migration ability of PMSCs through the DANCR/miR-656-3p/HIF-1α axis.
Atomic insights of an up and down conformation of the Acinetobacter baumanniiF1‐ATPase subunit ε and deciphering the residues critical for ATP hydrolysis inhibition and ATP synthesis
Authors: Saw Wuan‐Geok , Le Khoa Cong Minh , Shin Joon , Kwek Jes Hui Min , Wong Chui Fann , Ragunathan Priya , Fong Tuck Choy , Müller Volker , Grüber Gerhard 
Published: June 2023

AbstractThe Acinetobacter baumannii F1FO‐ATP synthase (α3:β3:γ:δ:ε:a:b2:c10), which is essential for this strictly respiratory opportunistic human pathogen, is incapable of ATP‐driven proton translocation due to its latent ATPase activity. Here, we generated and purified the first recombinant A. baumannii F1‐ATPase (AbF1–ATPase) composed of subunits α3:β3:γ:ε, showing latent ATP hydrolysis. A 3.0 Å cryo‐electron microscopy structure visualizes the architecture and regulatory element of this enzyme, in which the C‐terminal domain of subunit ε (Abε) is present in an extended position. An ε‐free AbF1‐ɑβγ complex generated showed a 21.5‐fold ATP hydrolysis increase, demonstrating that Abε is the major regulator of AbF1‐ATPase's latent ATP hydrolysis. The recombinant system enabled mutational studies of single amino acid substitutions within Abε or its interacting subunits β and γ, respectively, as well as C‐terminal truncated mutants of Abε, providing a detailed picture of Abε's main element for the self‐inhibition mechanism of ATP hydrolysis. Using a heterologous expression system, the importance of Abε's C‐terminus in ATP synthesis of inverted membrane vesicles, including AbF1FO‐ATP synthases, has been explored. In addition, we are presenting the first NMR solution structure of the compact form of Abε, revealing interaction of its N‐terminal β‐barrel and C‐terminal ɑ‐hairpin domain. A double mutant of Abε highlights critical residues for Abε's domain–domain formation which is important also for AbF1–ATPase's stability. Abε does not bind MgATP, which is described to regulate the up and down movements in other bacterial counterparts. The data are compared to regulatory elements of F1‐ATPases in bacteria, chloroplasts, and mitochondria to prevent wasting of ATP.