bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les frontières négociées des assemblées citoyennes. Le cas de la Convention citoyenne pour le climat (2019-2020)
Authors: Gaborit Maxime , Jeanpierre Laurent , Rozencwajg Romane 
Published: February 2023

Comme d’autres mini-publics, la Convention citoyenne pour le climat (CCC), qui s’est tenue en France en 2019 et 2020, a dû répondre à une double contrainte : pour que ses conclusions soient jugées valables du point de vue de la délibération, elle devait apparaître comme imperméable aux influences extérieures, mais pour que ses conclusions aient du poids, les membres de l’assemblée étaient incité·es à développer des alliances avec d’autres acteurs et actrices, et à porter ainsi le débat au-delà des murs de l’assemblée. Cette tension entre ouverture et fermeture, délibération et participation, mini-public et grand public, de plus en plus problématisée au sein des théories de la démocratie délibérative, a été résolue à travers certaines des caractéristiques organisationnelles et logistiques du dispositif, comme dans ces longues intersessions au cours desquelles les citoyen·nes ont été convié·es à investir leur rôle, ce qui a constitué un élément décisif dans la publicité des débats. L’article, qui repose sur une enquête ethnographique tout au long du processus, montre comment les frontières de la CCC ont été construites puis renégociées par les citoyen·nes et d’autres parties prenantes. Nous mettons en lumière un double mouvement d’importation d’acteurs et actrices externes et d’exportation vers le grand public, ainsi que des phénomènes de constitution progressive d’un « Nous » de l’assemblée citoyenne, opposé à un « Eux » qui renvoie aux institutions politiques et économiques comme au reste de la population nationale. Nous suggérons que tous ces mécanismes jouent un rôle majeur sur le devenir des mesures et qu’ils devraient faire l’objet d’une analyse plus systématique dans d’autres mini-publics et assemblées citoyennes.
Differentiating pellucid marginal degeneration from keratoconus with epithelial mapping
Authors: Sujeevan S. , De Silva A. H. N. , Vishnupriya R. , Edirisooriya S. M. , Wariyapola D. 
Published: February 2023

Introduction: Keratoconus and pellucid marginal degeneration are corneal ectatic disorders which cause thinning of cornea. They can be differentiated by epithelial mapping as keratoconus shows a typical appearance. Objective: To differentiate pellucid marginal degeneration from keratoconus with epithelial mapping. Methodology: It is a case series observational study of four young adults carried out over period of one month from September 2021 to October 2021. Conclusion: Even though in some cases of keratoconus and pellucid marginal degeneration show similar topography pattern, keratoconus shows typical "doughnut" appearance in epithelial mapping and PMD shows inferior thinning of epithelium in epithelial mapping.
Abstract 117
Authors: Sriramaneni Nikitha , Ganavi Y.P , Kalra Pramila 
Published: February 2023

Background: Hemiagenesis of thyroid gland is a rare congenital disorder. It can be associated with a variety of thyroid disorders.

Case Report: A 35 year oldfemale presented withsignificant unintentional weight loss, difficulty in swallowing and tremors of hands from 2 months duration. Herserum TT3, TT4 levels were elevated andserum TSH was suppressed. Tc99 scan of thyroid gland showed an increased trapping function in the isthmus and left lobe of thyroid likely toxic adenoma. She was started on carbimazole.
On follow up, a goiter was palpable on left side and right lobe of thyroid was not palpable. An USGthyroid gland was done in which right lobe of the thyroid gland was not visualized. There were 2 isoechoic nodules in the left lobe of thyroid 5 x 3 mm and 5 x 4 mm with a hypoechoic rim (TIRADS 2 score). As there was no evidence of tracer uptake in the region of right lobe of thyroid gland with increased homogenous tracer uptake (uptake at 20 mins- 4.7%) in the isthmus and left lobe of thyroid gland, a possibility of Graves’ disease was considered. TSHR Antibody testing was planned on follow up.

Discussion: Thyroid hemiagenesis is a rare congenital disorder in which one lobe of the thyroid gland fails to develop while the other lobe develops normally with or without an isthmus. The prevalence of thyroid hemiagenesis is reported to vary from 0.05% to 0.5%. Most of them are euthyroid but may be associated with hyper- or hypothyroidism. Left lobe hemiagenesis is common with left to right hemiagenesis ratio of 4:1. Various extrathyroidal abnormalities can coexist with thyroid hemiagenesis like parathyroid adenoma or hyperplasia, congenital disorders etc.

Conclusions: Graves’ disease with thyroid hemiagenesis must be considered in cases of unilateral homogenous increased tracer uptake on thyroid scintiscan. Thyroid ultrasonography is a non-invasive, inexpensive, and valuable modality for a quick diagnosis of thyroid hemiagenesis and differential diagnosis from other causes.
Abstract 152
Authors: Suran Apoorva , Maldar Aasim , Shah N. F. , Chauhan P. H. 
Published: February 2023

Background: Anti-Mullerian hormone (AMH) is secreted by small antral follicles and is elevated in PCOS. Unlike serum total testosterone, its value remains constant irrespective of the phase of menstrual cycle. Serum AMH could prove to be a promising marker of disease activity and response to therapy. Combined estrogen-progestin (CEP) pills are considered treatment of choice in PCOS, but their effect on serum AMH has not been widely studied.

Objective: To study the effect of six months of CEP pills on serum AMH and testosterone in PCOS patients.

Methods: 55 consecutive females, above 18 years and diagnosed with PCOSby Rotterdam Criteria, who attended our outpatient clinic from July 2020 to April 2021, were enrolled. Hirsutism was assessed by modified Ferriman-Gallwey Scoring (mFGS). Serum AMH and total testosterone were measured at baseline, and all the patients were initiated on combination of ethinyl estradiol (35 mcg) with cyproterone acetate (2 mg), to be taken orally for 21 days every month for a period of 6 months. Serum AMH and total testosterone were reassessed again after 6 months of CEP therapy. Out of total 55 patients, 14 were lost to follow up due to Covid-19 pandemic. A total of 24 patients completed 6 months of CEP therapy, while remaining discontinued the treatment after a mean period of 2 months because of perceived adverse effects.

Results: Mean age of study population was 22.8 ± 4.4 years. At baseline, hyperandrogenic features like acne, hirsutism and hair fall were present in 41 (74.5%), 35 (63.6%) and 42 (76.4%) females, respectively. Mean mFGS was 5.6 ± 2.8. Oligomenorrhoea was reported by38 (69.1%) females. Mean AMH levels and testosterone were 12.1 ± 7.1 ng/ml and 46.6 ± 20.1 ng/dl, respectively. There were 17 (30.9%) patients who had testosterone ³60 ng/dl, while 42 females (76.3%) had high AMH levels (³6.8 ng/ml). Baseline AMH positively correlated with BMI and serum LH level.
Post-treatment, there was significant decrease inacne, hirsutism and hair fall (P < 0.001 for all). Mean mFGS (5.6 ± 2.8 vs 4.2 ± 2, P < 0.001) and mean serum AMH levels (12.1 ± 7.1 ng/ml vs 10.4 ± 7 ng/ml, P = 0.002) demonstrated a significant improvement. Serum testosterone levels decreased post therapy (46.6 ± 20.1 vs 42.3 ± 17.4 ng/dl, P = 0.08), but did not reach statistical significance (table 1). Testosterone and AMH levels did not show any correlation (R = 0.054, P = 0.7).

Conclusions: AMH levels show a significant decline after 6 months of treatment, corresponding to improvement in hyperandrogenic symptoms and mFGS. AMH can prove to be a promising marker of disease activity in PCOS. The major limitation of the study was its small sample size, and more robust studies are needed.
Abstract 64
Authors: Nutakki Krishna Veni , Deb Prasun , Nalla Smitha , Vulpala Alekya 
Published: February 2023

Introduction - Paediatric obesity has increased substantially over the past four decades. The most common cause is exogenous obesity followed by endocrine and genetic aetiologies. Among genetic causes, mutations in MCR4, POMC and imprinted genes in 15q11, are common.
We present here a case of obesity, growth hormone deficiency and hypothyroidism in a patient with homozygous PRMT7 mutation, a rare mutation that has been reported in less than 15 cases, and is causative of SBIDDS (short stature and brachydactyly, intellectual developmental disability, and seizures) phenotype.

Case report: A 9 yearoldmale child, second bornof third degreeconsanguineous parents, presented to the Endocrine OPD with short stature. Birth weight was 2 kg. There was a history of delayed cry at birth, NICU stay and prolonged jaundice in the neonatal period. In the first month of life, a mid-sized PDA was detected and was conservatively managed. Spontaneous closure of PDA was noted at 3 years. There was history of developmental delay andmild intellectual deficit. Seizure disorder was diagnosed and he was on treatment. Excessive weight gain was observed at the age of 4 years. On examination, he was short with abdominal obesity, brachydactyly, simian crease and macroglossia. Height was below 3rd centile and weight at the 97th percentile. SMR was pre-pubertal:A1P2.
Investigations confirmed growth hormone deficiency and primary hypothyroidism for which he was commenced on growth hormone therapy and levothyroxine. ONDST was negative. Genetic evaluation for Prader Willi syndrome and Angelman syndrome was negative. Whole exome sequencing revealed homozygosity for PRMT7 mutation with both parents heterozygous for the same gene mutation. His twin sibling was also found to be homozygous for the mutation.

Discussion - PRMT7 is expressed ubiquitously in humans during development and into adulthood, and catalyzes the transfer of methyl groups playing a critical role in euchromatin maintenance, RNA splicing, cell growth and differentiation. PRMT7 also contributes to core skeletal integrity, through its regulation of the Wnt signaling pathway. Biallelicmutations in PRMT7 in humans are rare with only 15 reported cases and cause an autosomalRecessivecondition characterized by short stature and brachydactyly, intellectual developmental disability, and seizures (SBIDDS) syndrome.
We report here some of the additional clinical features associated with this genetic condition-obesity, growth hormone deficiency and hypothyroidism. Further studies are required to delineate the natural history and molecular basis of this disorder, which may place it as one of the genetic etiologies of obesity.
Abstract 74
Authors: Sharma R. K. , Mehta Urvansh 
Published: February 2023

A 18 year old male presented to Endocrinology OPD with a 13 year old history of difficulty in walking and knee deformity. He had a 4-year-old history of scrotal swelling. Despite having done corrective surgery, the deformity was refractory and again reverted in the last 5 years. The remaining physical examination was unremarkable.
Upon detail history and evaluation, his Sexual Maturity Rating was around 4-5 with Vitamin D Deficiency. Patient’s intact PTH was 468 pg/ml. Radiological evaluation was showing decreased bone density and valgus deformity of knee. Patient’s Urine routine came was significantly acidic and upon administration of steroid improvement was seen.
This gave a rare presentation of Rickets with Proximal RTA and Hyperparathyroidism. Patient was evaluated and followed up with vitamin and mineral supplementation. The relation of antagonizing factors disrupting the equilibrium between parathyroid hormone and calcium at tubular level is clinically scarcely reported. Active follow up and prompt, effective treatment is vital in such cases.
ROS1 in non-small-cell lung carcinoma: A narrative review
Authors: Nathany Shrinidhi , Batra Ullas , Sachdeva Rashi , Sharma Mansi , Amrith BP , Vaidya Shriya 
Published: February 2023

ABSTRACT
ROS1 rearranged non-small-cell lung cancer (NSCLC) is a distinct molecular subtype of NSCLC, accounting for 2% of cases. Typically, these are genomic rearrangements resulting in a fusion oncoprotein that causes unabated constitutive signaling. Patients with ROS1 rearranged NSCLC have distinct clinical and histologic profiles and show excellent outcomes with various small molecule tyrosine kinase inhibitors. For the preparation of this review, we searched the literature in databases like PubMed, Embase, and Scopus with keywords such as “ROS1”, “ROS1 crizotinib”, and “Oncogene NSCLC.” We included 72 articles. This is a narrative review of the molecular biology, clinical, and pathologic characteristics, detection methods, and management of ROS1 rearranged lung cancer.
Predictors of severity in COVID-19
Authors: Peraka Ramadevi , Shalini M. B. , Reddy Jayabhasker 
Published: February 2023

Background:
In the context of home monitoring of severe acute respiratory syndrome coronavirus-2 disease (COVID-19) patients, it is imperative to evaluate the accuracy of finger pulse oximetry oxygen saturation (SpO2) in the assessment of hypoxia.

Methods:
Retrospective data analysis was performed on (n = 132) hospitalised COVID-19 patients with various levels of severity, in whom SpO2, haematological, biochemical and arterial blood gas (ABG) parameters were measured within 48 h after admission. Discrepancy between SpO2 and arterial blood oxygen saturation SaO2 was compared between mild, moderate and severe COVID-19 to assess the accuracy of finger pulse oximetry.

Results:
We found that total white blood cell count, neutrophil %, neutrophil–lymphocyte ratio, platelet–lymphocyte ratio, ferritin, C-reactive protein and lactate dehydrogenase (LDH) were significantly increased in severe COVID-19, while lymphocyte % was significantly less when compared to mild and moderate cases. Multivariable analysis suggested that red cell distribution width (RDW) and LDH together account for significant variance in the severity of disease. The SpO2 and SaO2 were significantly less in the severe group. The difference between SpO2 and SaO2 has a clinically meaningful albeit statistically nonsignificant trend with the discrepancy greater in severe COVID-19 cases when compared to mild and moderate cases.

Conclusions:
Finger pulse oximetry has the potential to underestimate the severity of hypoxia in severe COVID-19 and this has implications in the decision to start oxygen therapy. RDW and LDH constitute the best parsimonious set of variables to predict severity.
Adverse effects associated with the use of N95 mask among health-care workers at the COVID-19 care units
Authors: Hussain Saad Abdulrahman , Mahmood Naza Mohammed Ali , Mahmood Trefa Mohammed Ali , Salih Neega Aras Mohammed , Abdulrahman Zainab Saad 
Published: February 2023

BACKGROUND:
Health-care workers have to use the N95 mask as a part of the protection kit during the COVID-19 pandemic. The adverse effects of such practice are not fully elucidated. The study aims to evaluate negative impacts of N95 face masks on health-care personnel at COVID-19 care units.

MATERIALS AND METHODS:
One hundred and twenty-two health-care workers (aged 20–58 years) from various health-care settings in Sulaimani, Iraq, from January to August 2020, were enrolled in this prospective, cross-sectional study. The physiological variables (blood pressure, heart rate, and oxygen saturation) were recorded before putting on the N95 mask and postremoval of the mask. The incidence of adverse effects such as headache, difficulty breathing, redness, irritation, and dizziness were also reported as a number and percent at the end of the work shift.

RESULTS:
There was a statistically significant difference in the physiological parameters after removal of the mask compared with baseline. Only diastolic pressure was significantly lower in those working >6 h when compared to those working 1–6 h. The changes in physiological markers were poorly and nonsignificantly associated with the duration of wearing the mask. Moreover, 67.2%–70.5% of the participants complain of headaches and breathing difficulties, while 45.9%–51.6% reported signs of itching, redness, and irritation. However, health-care workers who put on the face mask >6 h showed signs of headache, breathing difficulties, and itching at the exposed areas higher than those working for 1–6 h.

CONCLUSION:
N95 mask negatively impacts the physiological variables of health-care providers. The adverse effects may lead to excessive exhaustion after long shifts in the intensive care unit during treatment of COVID-19 patients.
COVID-19
Authors: de Melo Maria do Carmo Barros , Ferri Priscila Menezes , de Vasconcelos Monica Maria Almeida , Reis Zilma Silveira Nogueira , Godoy Solange Cervinho Bicalho , Palmeira Vitória Andrade , Rocha Gabriel , Torres Rosalia Morais , Tupinambás Unaí 
Published: February 2023

BACKGROUND:
Educators and health assistants can act as key players in controlling the pandemic. In general, they are respected by the community, especially in rural areas, and can help guide and raise the population's awareness of preventive measures. The objective of this paper is to evaluate the results in knowledge progress of an e-learning course offered to educators and health assistants by a public university and to analyze the profile and satisfaction of the participants.

MATERIALS AND METHODS:
A single group pre- and post-test design based on a questionnaire, interventional, study was conducted in the period from April 20th to June 20th. All participants of the course answered sociodemographic and satisfaction questionnaire and a pre- and post-test. Data were descriptively arranged and regarding the distribution and comparison of means and frequency, paired t-test for group comparisons. P < 0.05 was statistically significant. Data were collected from the Moodle® teaching platform, without identifying the participants.

RESULTS:
A total of 674 participants were enrolled in the five groups, and 583 concluded the course (86.5%). The reasons for those who did not access the entire course (n = 47) were: Lack of time, difficulty in accessing the internet, and lack of experience with distance learning courses. On the evaluation of the course platform, from the tutors in general and the degree of satisfaction in several questions, participants marked maximum grades. The comparison between pre- and post-proficiency scores showed increased proficiency of the enrolled groups (P < 0.0001).

CONCLUSIONS:
The course contributed to the training of health assistants and educators, preparing them to act in a participatory way in the prevention and control of the pandemic. The course was well evaluated and there was a progression of knowledge by the participants.
Academic burnout among trainee teachers during the COVID-19 pandemic
Authors: Bouhaba Abdelmounaim , Madhi Youssef El , Soulaymani Abdelmajid , Hami Hinde 
Published: February 2023

BACKGROUND:
The trainee teacher seems to be more and more faced with frustration and stress during the training phase, caused by accumulation of requirements and duties, making them susceptible to the risk of burnout. The purpose of this work is to study the academic burnout of trainee teachers at the Rabat-Sale-Kenitra region's Regional Center for Education and Training Professions during the COVID-19 pandemic.

MATERIALS AND METHODS:
Seven hundred thirty-nine trainee teachers responded to a self-questionnaire comprising the Maslach Burnout Inventory–Student Survey scale in its French validated version, as well as stress factors during the academic year 2020–2021. Both inferential and descriptive methods of data analysis were used to represent the effect of sociodemographic variables on burnout levels during the COVID-19 pandemic.

RESULTS:
In agreement with the literature, most of trainee teachers show moderate and high levels of academic exhaustion; the main stressors presented are financial instability and training overload, and the level of study influences the scale of burnout among trainee teachers.

CONCLUSION:
The result of this study can serve as a predictor of academic burnout among Moroccan trainee teachers.
Evaluating the usability of a national health information system with heuristic method
Authors: Bouraghi Hamid , Rezayi Sorayya , Amirazodi Shahrzad , Nabovati Ehsan , Saeedi Soheila 
Published: February 2023

BACKGROUND:
Hospital Statistics and Information System is one of the most important health information systems in Iran used in all hospitals in this country. Usability problems can reduce the speed and precision of users when interacting with this system. This study aimed to identify the usability problems of a national health system called “AVAB”.

MATERIALS AND METHODS:
This descriptive cross-sectional study was conducted in 2020, and three experts evaluated the usability of this system independently by the heuristic evaluation method. Nielsen's usability principles were used to identify usability problems and to classify their severity.

RESULTS:
A total of 86 unique problems were identified. The highest number of problems were related to the two principles of “help and documentation” and “match between system and the real world” with 23 and 11 usability problems, respectively. The lowest number of problems were related to the two principles of “visibility of system status” and “help users recognize, diagnose, and recover from errors,” each with three problems. 58.1% of the identified problems were in the group of major and catastrophic problems.

CONCLUSIONS:
With the help of heuristic evaluation method, a significant number of usability problems of Hospital Statistics and Information System were identified. Most of the identified problems were major and catastrophic, and it is necessary to solve these problems by the designers and developers of this system.