bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes
Authors: Florens Nans , Kasam Rajesh K. , Rudman-Melnick Valeria , Lin Suh-Chin , Prasad Vikram , Molkentin Jeffery D. 
Published: January 2023

Background:
Acute kidney injury (AKI) is a short-term life-threatening condition that, if survived, can lead to renal insufficiency and development of chronic kidney disease. The pathogenesis of AKI and chronic kidney disease involves direct effects on the heart and the development of hypertrophy and cardiomyopathy.

Methods:

We used mouse models of ischemia/reperfusion AKI and unilateral ureteral obstruction to investigate the role of IL-33 (interleukin-33) and its receptor-encoding gene
Il1rl1
(also called ST2L [suppression of tumorigenicity 2]) in cardiac remodeling after AKI. Mice with cell type–specific genetic disruption of the IL-33/ST2L axis were used, and IL-33 monoclonal antibody, adeno-associated virus encoding IL-33 or ST2L, and recombinant IL-33, as well.

Results:

Mice deficient in
Il33
were refractory to cardiomyopathy associated with 2 models of kidney injury. Treatment of mice with monoclonal IL-33 antibody also protected the heart after AKI. Moreover, overexpression of IL-33 or injection of recombinant IL-33 induced cardiac hypertrophy or cardiomyopathy, but not in mice lacking
Il1rl1
. AKI-induced cardiomyopathy was also reduced in mice with cardiac myocyte–specific deletion of
Il1rl1
but not in endothelial cell- or fibroblast-specific deletion of
Il1rl1
. Last, overexpression of the ST2L receptor in cardiac myocytes recapitulated induction of cardiac hypertrophy.

Conclusions:
These results indicate that IL-33 released from the kidney during AKI underlies cardiorenal syndrome by directly signaling to cardiac myocytes, suggesting that antagonism of IL-33/ST2 axis would be cardioprotective in patients with kidney disease.
Estimating the Impact of Assimilating Cirrus Cloud–Contaminated Hyperspectral Infrared Radiances for Numerical Weather Prediction
Authors: Marquis Jared W. , Dolinar Erica K. , Garnier Anne , Campbell James R. , Ruston Benjamin C. , Yang Ping , Zhang Jianglong 
Published: January 2023

Abstract
The assimilation of hyperspectral infrared sounders (HIS) observations aboard Earth-observing satellites has become vital to numerical weather prediction, yet this assimilation is predicated on the assumption of clear-sky observations. Using collocated assimilated observations from the Atmospheric Infrared Sounder (AIRS) and the Cloud–Aerosol Lidar with Orthogonal Polarization (CALIOP), it is found that nearly 7.7% of HIS observations assimilated by the Naval Research Laboratory Variational Data Assimilation System–Accelerated Representer (NAVDAS-AR) are contaminated by cirrus clouds. These contaminating clouds primarily exhibit visible cloud optical depths at 532 nm (COD532nm) below 0.10 and cloud-top temperatures between 240 and 185 K as expected for cirrus clouds. These contamination statistics are consistent with simulations from the Radiative Transfer for TOVS (RTTOV) model showing a cirrus cloud with a COD532nm of 0.10 imparts brightness temperature differences below typical innovation thresholds used by NAVDAS-AR. Using a one-dimensional variational (1DVar) assimilation system coupled with RTTOV for forward and gradient radiative transfer, the analysis temperature and moisture impact of assimilating cirrus-contaminated HIS observations is estimated. Large differences of 2.5 K in temperature and 11 K in dewpoint are possible for a cloud with COD532nm of 0.10 and cloud-top temperature of 210 K. When normalized by the contamination statistics, global differences of nearly 0.11 K in temperature and 0.34 K in dewpoint are possible, with temperature and dewpoint tropospheric root-mean-squared errors (RMSDs) as large as 0.06 and 0.11 K, respectively. While in isolation these global estimates are not particularly concerning, differences are likely much larger in regions with high cirrus frequency.
Diagnostic outcome and safety of plugged liver biopsy in high-risk patients: a systematic review and meta-analysis
Authors: Giri Suprabhat , Agrawal Dhiraj , Gopan Amrit , Varghese Jijo , Tripathy Taraprasad 
Published: January 2023

Background Percutaneous liver biopsy is the gold standard test for the assessment of liver disease. In patients with coagulopathy, ascites, post-transplantation, and hypervascular tumors, biopsy is associated with increased risk of adverse events (AEs). Transjugular liver biopsy (TJLB) is recommended in these conditions but is expensive and unavailable at many centers. Plugged liver biopsy (PLB) provides an alternate diagnostic modality in these high-risk cases. Purpose To analyze the pooled diagnostic outcome and safety of PLB in high-risk cases. Material and Methods A literature search of various databases from January 1990 to July 2022 was conducted for studies evaluating the outcome of PLB in high-risk cases. The primary outcomes were pooled sample adequacy and AEs. Pooled event rates across studies were expressed with summative statistics. Results A total of 17 studies (2329 patients) were included in the meta-analysis. The pooled proportion of sample adequacy was 98.9% (95% confidence interval [CI]=98.2–99.6). Severe AEs, major bleeding, and minor AEs were seen in 0.7% (95% CI=0.1–1.3), 0.4% (95% CI=0.1–0.8), and 11.5% (95% CI=2.4–20.6) of the patients. There was only one reported mortality, giving a pooled incidence of 0.0002% (95% CI=0.0–0.0038). Compared to TJLB (5 studies, n = 336), there was no difference in either sample adequacy (odds ratio [OR]=2.34, 95% CI=0.83–6.58) or risk of serious AEs (OR=0.47, 95% CI=0.173–1.31). Conclusion PLB can be safely performed on patients with coagulopathy and/or ascites with high sample adequacy rates and low incidence of AEs and mortality.
Sliding Spine Relocation Surgery with Anterior Septal Reconstruction
Authors: Fleury Curado Thomaz , El Abany Ahmed , Most Sam P. 
Published: January 2023

Study Design: Technical note. Objective: The lower nasal architecture is dependent on caudal septal integrity. Deviations of the caudal septum can compromise nasal airflow. The presence of anterior nasal spine deviations contributes to septal and medial crural shifting with ipsilateral encroachment. It is essential to identify nasal spine deviation during surgery in order to reconstruct the septum in a midline position at its base. This allows an appropriate management plan that creates a better functional and aesthetically pleasing outcome. A stable midline anterior nasal spine is warranted to support the newly reconstructed straight caudal strut, which can be effectively corrected by anterior septal reconstruction. Methods: The proposed method intends to combine anterior nasal spine centralization with correcting caudal septal deviation and nasal obstruction through a modified extracorporeal septoplasty technique. We describe a novel technique to centralize the deviated anterior nasal spine using the piezoelectric device by performing a contralateral adjacent ostectomy and en-bloc relocation and fixation of the anterior nasal spine with microplates and screws. Results: This surgical approach creates a stable caudal septum and a centrally positioned anterior nasal spine, which improves nasal airflow and ensures a stable repair. Conclusion: Sliding spine relocation surgery with anterior septal reconstruction repositions a deviated anterior nasal spine and corrects caudal septum deviation, that can impair the nasal airway.
Association Between Early Surgery and Postoperative Opioid Use in Patients With Lumbar Disc Herniation: A Propensity Score-Matching Analysis Using an Administrative Claims Database in Japan
Authors: Honda Akira , Iizuka Yoichi , Tokue Mieda , Takasawa Eiji , Ishiwata Sho , Tomomatsu Yusuke , Ito Shunsuke , Inomata Kazuhiro , Okada Akira , Matsui Hiroki , Yasunaga Hideo , Chikuda Hirotaka 
Published: January 2023

Study Design Retrospective cohort study Objectives This study aimed to investigate whether early surgery shortens the duration of opioid use in patients who underwent surgery with lumbar disc herniation. Methods We extracted patients who underwent surgery at least 2 weeks after they were diagnosed with lumbar disc herniation between April 2014 and May 2021. Opioid use after surgery was compared between patients who underwent surgery within 90 days (early surgery group) and 90 days or later (late surgery group). Propensity-score-matching analysis and multivariable Cox hazard regression analysis with a restricted cubic spline model were conducted to evaluate the association between the timing of surgery and termination of opioid use after surgery. Results A total of 1597 eligible patients were identified, with 807 (51%) in the early surgery group. In the propensity-score-matched cohort, the early surgery group had a significantly lower proportion of opioid use than the control group (28% vs 48%, percent difference −20%, P < .001). Multivariable Cox hazard regression analysis showed that early surgery was significantly associated with the earlier termination of opioid use (HR, 3.13; 95% CI, 1.97-4.97; P < .001). Restricted cubic spline model showed a monotonically decreased hazard ratio and decreased hazard ratio of .50 in patients who underwent surgery 111 days or later after the diagnosis. Conclusions Early surgery, especially within 90 days, was associated with earlier opioid use termination after surgery. Regarding the duration of opioid use following surgery, surgical treatment may be preferable to perform within around 4 months after the diagnosis.
Comparison of Trunk and Pelvic Kinematics in Youth Baseball Pitchers With and Without Upper Extremity Pain: A Cross-Sectional Study
Authors: Fava Anthony W. , Giordano Kevin A. , Friesen Kenzie B. , Nguyen Adam , Oliver Gretchen D. 
Published: January 2023

Background:Motion of the pelvis and trunk during baseball pitching is associated with increased upper extremity (UE) kinetics. Increased kinetics on the UE may lead to throwing-arm pain in youth pitchers. Limited biomechanical comparisons have been conducted on youth pitchers with and without throwing-arm pain to identify mechanical risk factors associated with pain.Purpose:To examine trunk and pelvic kinematics in youth baseball pitchers with and without UE pain.Study Design:Cross-sectional study; Level of evidence, 3.Methods:A total of 26 male youth baseball pitchers (mean age, 12.7 ± 1.5 years; mean height, 162.2 ± 12.9 cm; mean weight, 52.6 ± 13.1 kg) were recruited to participate. An electromagnetic tracking system was used to obtain kinematic data during the fastball pitch. Data from a health history questionnaire was examined. Participants who answered “yes” to experiencing pain and who selected a region on their UE as the pain location were placed into the UE pain group. Participants who responded “no” to experiencing pain were placed into the pain-free group. We compared between-group differences in trunk rotation, flexion, and lateral flexion; pelvic rotation, anteroposterior tilt, and lateral tilt; and hip-shoulder separation from peak knee height to ball release of the baseball pitch using 1-dimensional statistical parametric mapping with an alpha level set at .05.Results:No statistically significant differences were observed between the UE pain and pain-free groups in the 7 trunk and pelvic kinematics analyzed from peak knee height to ball release ( P > .05).Conclusion:Trunk and pelvic kinematics during the pitching motion did not differ between pain and pain-free groups of youth baseball pitchers.
On the matildite–bohdanowiczite solid-solution series
Authors: Alexandre Paul , Aisida Moses 
Published: January 2023

AbstractA high-grade ore sample from the Cu–Zn–Au Photo Lake volcanogenic massive sulfide deposit (Flin Flon–Snow Lake greenstone belt, Manitoba, Canada) contains a Bi–Ag sulfo-selenide with a composition situated approximately in the middle of the S–Se substitution range (Se ≈ 0.86 apfu and S ≈ 1.05 apfu). These new data, combined with a literature compilation of all publicly available matildite and bohdanowiczite compositional data, reveal a nearly complete range of S–Se substitution between these two minerals, with only the section between BiAgSe0.78S1.18 and BiAgSe0.25S1.75 – about a quarter of the complete S–Se range – not yet documented. These observations suggest that a complete solid-solution series between matildite and bohdanowiczite, as previously suspected, might exist and in a manner similar to the galena–clausthalite complete solid-solution series.
Prognostic significance of frailty status in patients with primary lung cancer
Authors: Wang Kai , She Quan , Li Min , Zhao Hongye , Zhao Weihong , Chen Bo , Wu Jianqing 
Published: January 2023

AbstractLung cancer has one of the highest morbidity and mortality rates in the world. Frailty is common in many countries and is a major cause of premature functional decline and premature death in older adults, and may affect the treatment and prognosis of lung cancer patients. To investigate the predictive value of frailty at diagnosis on all-cause mortality in lung cancer patients, this study retrospectively collected and analysed clinical information on lung cancer patients from 2015–2018. A total of 1667 patients with primary lung cancer were finally included in this study. The median follow-up time of patients was 650 (493, 1001.5) days. A total of 297(17.8%) patients had FI-LAB(the frailty index based on laboratory test) status of frail at the moment of diagnosis and the all-cause mortality rate for all patients was 61.1% (1018/1667). In a univariate model, we found a higher total all-cause mortality risk in frail patients (frail vs. robust, HR(hazard ratio) = 1.616, 95% CI(confidence interval) = 1.349,1.936), after balancing other variables combined into model 1 to model 6. The results were analyzed visually using ROC(Receiver operating characteristic) curves with nomogram and the AUC values ranged from 0.866–0.874. The final inclusion of age, TNM stage, CCI(Charlson comorbidity index) score, surgery history and chemotherapy into a multifactorial model balanced the predictive power of frailty grading on all-cause mortality. The study showed that for lung cancer patients, the higher the level of frailty at diagnosis, the higher the risk of all-cause mortality. In the context of widespread electronic medical records in hospitals, it is convenient and feasible to use FI-LAB to assess the prognosis of lung cancer patients.
The effect of large follicle puncture and aspiration on the outcomes of IVF-ET in patients with asynchronized follicles under the long GnRH-a protocol: a retrospective cohort study
Authors: Wang Yixuan , Pang Conghui , Wu Haicui , Wei Chaofeng , Yu Yi , Xin Xin , Lian Fang 
Published: January 2023

Abstract
Objective
This retrospective study aimed to explore whether puncturing and aspirating asynchronized large follicles during long GnRH-a protocol COH impacted IVF-ET outcomes.

Methods
A total of 180 patients with asynchronized follicles during long GnRH-a protocol COH were retrospectively analyzed. They were divided into a puncture group, Group 1 (n = 81), and a non-puncture group, Group 2 (n = 99), according to whether puncture and aspiration were performed on the prematurely developing large follicles. The data of the selected patients were statistically analyzed to assess the effect of large follicle puncture and aspiration during ovulation induction on the final pregnancy results. In addition, we tentatively divided these 180 patients into either Group A (DF ≤ 14 mm) or Group B (DF > 14 mm) according to whether the diameter of the dominant large follicles (DF) exceeded 14 mm at the time of appearance. These two groups were then further divided into four subgroups: Subgroup A1 (DF ≤ 14 mm, patients underwent large follicle puncture), Subgroup A2 (DF ≤ 14 mm, patients did not undergo large follicle puncture), Subgroup B1 (DF > 14 mm, patients underwent large follicle puncture), and Subgroup B2 (DF > 14 mm, patients did not undergo large follicle puncture) based on whether large follicle puncture and aspiration were performed or not, aiming to compare the effects of large follicle puncture and aspiration on the clinical outcomes of patients with dominant large follicles at different time points.

Results
Group 1 exhibited significantly higher oocyte maturation rate (92.3% vs. 88.9%, P = 0.009) and high-quality embryo rate (75.2% vs. 65.7%, P = 0.007) compared with Group 2. No differences were observed in the number of oocytes retrieved, 2PN fertilization rate, clinical pregnancy rate, abortion rate, and live birth rate between the two groups (P > 0.05). When the dominant large follicles' diameter was ≤ 14 mm, the final oocyte maturation rate (92.7% vs. 88.1%, P = 0.023), high-quality embryo rate (72.9% vs. 61.8%, P = 0.047) and live birth rate (54.5% vs. 31.9%, P = 0.043) of Subgroup A1 were significantly higher than those of Subgroup A2. In contrast, when the dominant large follicles' diameter was > 14 mm, no statistical difference was observed in all data.

Conclusions
Large follicle puncture and aspiration in long GnRH-a protocol COH could improve the oocyte maturation rate and high-quality embryo rate in patients with asynchronized follicles. However, clinical pregnancy and live birth rates were not significantly improved. In addition, when the dominant follicles' diameter did not exceed 14 mm, large follicles puncture and aspiration significantly improved the patient's oocyte maturation rate, high-quality embryo rate and live birth rate.
Predictive factors for microvascular recovery after treatments for diabetic retinopathy
Authors: Lee Junyeop , Kim Yoon-Jeon , Lee Joo-Yong , Yoon Young Hee , Kim June-Gone 
Published: January 2023

AbstractBackgroundTo identify factors associated with microvascular recovery after intravitreal bevacizumab or panretinal photocoagulation (PRP) in diabetic retinopathy (DR).MethodsWe retrospectively reviewed 320 eyes/patients with DR treated with intravitreal bevacizumab and/or PRP. Two consecutive fluorescein angiographies (FAs) of each eye were compared. The number of microaneurysms and the area of capillary non-perfusion were calculated automatically using ImageJ software. Microvascular recovery was defined as a marked reduction in the numbers of microaneurysms (< 20%) or a marked reduction in the area of capillary non-perfusion (< 50%) in 45-degree fields or a complete regression of new vessels in ETDRS 7 standard fields. Baseline FA findings and changes in the ocular and systemic factors were analyzed.ResultsTwenty-eight (8.8%) of the 320 total eyes were found to meet the criteria of microvascular recovery after the treatments. Multivariate analysis revealed the presence of diffuse capillary telangiectasis (P = .003) and late disc leaking (P = .007) on baseline FA and a reduction of glycated hemoglobin (P = .005) during the follow-up period were predictive factors of microvascular recovery after the treatments. Although the microvascular recovery group presented with a significant improvement of BCVA after the treatments, the baseline BCVA could not predict the microvascular recovery after the treatments.ConclusionsDiffuse capillary telangiectasis or late disc leaking on baseline FA and improved glycemic control positively predicted the microvascular recovery after treatments for DR.
Determinants of trust in healthcare facilities among community-based health insurance members in the Manna district of Ethiopia
Authors: Akafu Wakuma , Daba Teferi , Tesfaye Edosa , Teshome Firanbon , Akafu Tesfaye 
Published: January 2023

Abstract
Background
Low-income countries, including Ethiopia, face substantial challenges in financing healthcare services to achieve universal health coverage. Consequently, millions of people suffer and die from health-related conditions. These can be efficiently managed in areas where community-based health insurance (CBHI) is properly implemented and communities have strong trust in healthcare facilities. However, the determinants of community trust in healthcare facilities have been under-researched in Ethiopia.

Objective
To assess the determinants of trust in healthcare facilities among community-based health insurance members in the Manna District of Ethiopia.

Methods
A community-based cross-sectional study was conducted from March 01 to 30, 2020 among 634 household heads. A multistage sampling technique was used to recruit the study participants. A structured interviewer-administered questionnaire was used to collect the data. Descriptive statistics were computed as necessary. Multivariable linear regression analyses were performed, and variables with a p-value < 0.05 were considered to have a significant association with households’ trust in healthcare facilities.

Results
In total, 617 households were included in the study, with a response rate of 97.0%. Household age (ß=0.01, 95% CI:0.001, 0.0013), satisfaction with past health services (ß=0.13, 95% CI:0.05, 0.22), perceived quality of services (ß= -0.47, 95% CI: -0.64, -0.29), perceived provider’s attitude towards CBHI members (ß = -0.68, 95% CI: -0.88, -0.49), and waiting time (ß= -0.002, 95% CI:- 0.003, -0.001) were determinants of trust in healthcare facilities.

Conclusion
This study showed that respondents’ satisfaction with past experiences, older household age, long waiting time, perceived poor quality of services, and perceived unfavorable attitudes of providers towards CBHI members were found to be determinants of trust in healthcare facilities. Thus, there is a need to improve the quality of health services, care providers’ attitudes, and clients’ satisfaction by reducing waiting time in order to increase clients’ trust in healthcare facilities.