bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venetoclax plus azacitidine compared with intensive chemotherapy as induction for patients with acute myeloid leukemia: retrospective analysis of an electronic medical record database in the United States
Authors: Zeidan Amer M. , Pollyea Daniel A. , Borate Uma , Vasconcelos Alberto , Potluri Ravi , Rotter David , Kiendrebeogo Zephirin , Gaugler Lona , Prebet Thomas , Strocchia Maria , Bonifacio Gaetano , Chen Clara 
Published: February 2023

AbstractIntensive chemotherapy (IC) is commonly used to achieve remission in patients with acute myeloid leukemia (AML). Venetoclax plus azacitidine (VEN-AZA) is FDA-approved to treat patients with AML aged ≥ 75 years or who are ineligible for IC. This retrospective analysis used de-identified electronic health records from the US-based Flatiron Health database from patients diagnosed 11/21/2018 to 10/31/2021 to compare treatment outcomes with VEN-AZA vs. IC. Patients were 1:1 propensity score-matched ($$N=276$$

N
=
276

). Assessments included rates of complete remission (CR) and hematopoietic stem cell transplant (HSCT), overall survival (OS), and relapse-free survival (RFS). CR and HSCT rates were higher with IC than with VEN-AZA (60.9% vs. 44.2% [P = 0.006] and 18.1% vs. 8.0% [P = 0.012], respectively). Median OS was 17.7 months in patients treated with IC and 11.3 months with VEN-AZA without censoring (P = 0.278) and 13.7 vs. 10.6 months, respectively, with censoring at HSCT (P = 0.584). Median RFS was 12.0 months in patients treated with IC vs. 9.5 months with VEN-AZA without censoring (P = 0.431) and 6.4 vs. 7.4 months, respectively, with censoring at HSCT (P = 0.444). No OS or RFS differences observed between the two arms reached statistical significance. Randomized controlled trials comparing the two approaches are warranted, as are novel approaches to reduce relapse rates following CR.
Experimental and DFT studies on the structural and optical properties of chitosan/polyvinyl pyrrolidone/ZnS nanocomposites
Authors: Abdelghany A. M. , Meikhail M. S. , Oraby A. H. , Aboelwafa M. A. 
Published: February 2023

AbstractChitosan/Polyvinyl pyrrolidone (CS/PVP) semi-natural polymeric blend involving gradient concentrations of ZnS nanoparticles (ZnS-NPS) was prepared via a simple casting method. In conjunction with computational density functional theory approaches (DFT), prepared samples were characterized by UV/Vis spectrophotometric studies and Fourier transform infrared measurements (FTIR) to take into account a detailed description of the different reaction mechanisms within the polymeric matrices. To conduct all calculations, the Becke three-parameter hybrid functional (B3LYP) correlation function used with the electron core potential basis set LANL2DZ was used. A detailed study of different reaction regimes was studied and reaction via Oxygen was observed to be preferred and compatible with that of the experimental data. UV/vis. Absorption experimental data were used to calculate the optical energy gap using the Mott-Davis equation and observed data was found to follow an indirect transition route.
Effect of environmental disturbances on crossflow instability
Authors: Placidi Marco , Ashworth Richard , Atkin Chris J. , Rolston Stephen 
Published: February 2023

AbstractWind tunnel experiments on the receptivity of three-dimensional boundary layers were performed in a range of freestream turbulence intensities, Tu, from 0.01%—the lowest level ever achieved in this type of work—up to 0.41%. This work confirms that for $$Tu=0.01\%$$

T
u
=
0.01
%

, and presumably below this level, the transition process is dominated by stationary modes. These are receptive to surface roughness and generate Type-I and Type-II secondary instabilities that eventually cause the transition to turbulence. The saturation amplitude of these stationary waves is highly sensitive to the level of environmental disturbances; the former is here recorded to be the highest in the literature, with the latter being the lowest. Travelling modes are still present; however, their influence on the transition process is marginal. At matched surface roughness levels, when the level of environmental disturbance is enhanced to $$Tu\ge 0.33\%$$

T
u
≥
0.33
%

, the travelling modes acquire more importance, strongly influencing the laminar/turbulent transition process, whilst the initial amplitude and growth of the stationary modes are hindered. For this level of Tu, is the interaction of steady and unsteady disturbances that produces highly amplified waves (Type-III), that quickly lead to nonlinear growth and anticipated turbulence. Finally, a simple rule of thumb is proposed, where the transition front was found to move forward by roughly $$10\%$$

10
%

chord for an increase in one order of magnitude in the Tu levels.
Graphical abstract
Outcomes of complex colorectal polyps managed by multi-disciplinary team strategies—a multi-centre observational study
Authors: Parker J. , Gupta S. , Shenbagaraj L. , Harborne P. , Ramaraj R. , Karandikar S. , Mottershead M. , Barbour J. , Mohammed N. , Lockett M. , Lyons A. , Vega R. , Torkington J. , Dolwani S. 
Published: February 2023

Abstract
Purpose
Team management strategies for complex colorectal polyps are recommended by professional guidelines. Multi-disciplinary meetings are used across the UK with limited information regarding their impact. The aim of this multi-centre observational study was to assess procedures and outcomes of patients managed using these approaches.

Method
This was a retrospective, observational study of patients managed by six UK sites. Information was collected regarding procedures and outcomes including length of stay, adverse events, readmissions and cancers.

Results
Two thousand one hundred ninety-two complex polyps in 2109 patients were analysed with increasing referrals annually. Most presented symptomatically and the mean polyp size was 32.1 mm. Primary interventions included endoscopic therapy (75.6%), conservative management (8.3%), colonic resection (8.1%), trans-anal surgery (6.8%) or combined procedures (1.1%). The number of primary colonic resections decreased over the study period without a reciprocal increase in secondary procedures or recurrence. Secondary procedures were required in 7.8%. The median length of stay for endoscopic procedures was 0 days with 77.5% completed as day cases. Median length of stay was 5 days for colonic resections. Overall adverse event and 30-day readmission rates were 9.0% and 3.3% respectively. Malignancy was identified in 8.8%. Benign polyp recurrence occurred in 13.1% with a median follow up of 30.4 months. Screening detected lesions were more likely to undergo bowel resection. Colonic resection was associated with longer stays, higher adverse events and more cancers on final histology.

Conclusion
Multi-disciplinary team management of complex polyps is safe and effective. Standardisation of organisation and quality monitoring is needed to continue positive effects on outcomes and services.
Makrozytäre Anämie und Polychondritis: VEXAS-Syndrom
Authors: Zeisbrich Markus , Schindler Viktoria , Krausz Máté , Proietti Michele , Mrovecova Pavla , Voll Reinhard E. , Glaser Cornelia , Röther Fabian , Warnatz Klaus , Venhoff Nils 
Published: February 2023

ZusammenfassungDas VEXAS-Syndrom (Akronym für Vacuoles, E1 enzyme, X‑linked, Autoinflammatory, Somatic) wurde Ende 2020 erstmals beschrieben und verursacht durch eine erworbene Mutation auf dem X‑Chromosom ein autoinflammatorisches Syndrom vorwiegend bei Männern im höheren Lebensalter. Klinisch zeichnet sich das VEXAS-Syndrom durch ein Mischbild aus rheumatologischer Erkrankung mit separaten hämatologischen Pathologien aus, wobei besonders häufig eine Polychondritis und fast immer eine makrozytäre Anämie auftreten. Anhand dieser Kasuistik werden die diagnostischen Kernpunkte zur Erkennung des VEXAS-Syndroms demonstriert.
Management of acute periprosthetic knee infection: a comparison of arthroscopic and open debridement
Authors: Bartsch A. , Krenn P. , Lubberts B. , Morgenstern M. , Pagenstert G. , Clauss M. 
Published: February 2023

Abstract
Introduction
In acute periprosthetic knee infections, debridement and implant retention (DAIR) is the preferred treatment prior to one- and two-stage revisions. The aim of this study is to compare the outcomes of arthroscopic and open debridement of infected primary total knee arthroplasties (TKA).

Material and methods
We analyzed clinical, laboratory, and antibiotic treatment data, collected in patients with periprosthetic knee infection treated with DAIR at a Swiss Level 1 orthopedic and trauma center over a 10-year period between January 2005 and May 2015. Inclusion criteria were primary total knee arthroplasty and early postoperative or acute hematogenous periprosthetic joint infection (PJI). The primary endpoint was the need for further revision surgery due to persistent infection. The secondary endpoint was the prosthesis salvage in further infection surgeries.

Results
Forty-two patients with 44 acute or hematogenous periprosthetic knee infections were included. We recorded 20 recurrent infections (45%) in our study population: 10 (77%) out of 13 in the arthroscopic DAIR group and 10 (32%) out of 31 in the open DAIR group. Two-stage revision, meaning complete removal of the TKA, insertion of a spacer and replantation at a second stage, had to be performed in three patients treated initially arthroscopically (23%) and in six patients treated initially with an open surgical procedure (21%).

Conclusions
Open debridement for acute periprosthetic knee infection shows clear benefits in terms of infection eradication and prosthesis salvage compared to arthroscopic DAIR.
Radiological presence of vascular loops in the cerebellopontine angle region in patients with unilateral Ménière’s disease
Authors: Lei Ping , Xia Kaijun , Li Jing , Liu Yingzhao , Zhou Renhong , Liu Jingjing , Wang Hongchang , Zhou Yue , Leng Yangming , Liu Bo 
Published: February 2023

Abstract
Objective
The relationship between vascular compression of the vestibulocochlear nerve and audio-vestibular symptoms remains controversial. We aimed to examine the radiological features of vascular loops signs in cerebellopontine angle (CPA) and internal auditory canal (IAC) in patients with unilateral Ménière’s disease (MD).

Methods
One hundred and thirty-seven patients with unilateral definite MD and 69 control subjects (138 ears) were enrolled. All subjects received magnetic resonance imaging of CPA-IAC. The configuration of vascular loops in CPA-IAC, based on the Kazawa classification system, from MD-affected, non-affected and control ears were compared. The associations between imaging findings and Ménière’s stage, electrocochleogram (EcochG) and caloric test were analyzed.

Results
(1) Among the MD-affected ears, 6 cases (4.4%) were classified as Kazawa type IA, 27 cases (19.7%) as IB, 60 cases (43.8%) as IIA, and 44 cases (32.1%) as IIB. No significant interaural difference in the distribution of Kazawa's types was found ($${x}^{2}$$

x

2

= 4.737, p = 0.578) in unilateral MD patients. (2) The distribution of Kazawa's types were not significantly different between the MD-affected ears and the control subjects ($${x}^{2}$$

x

2

= 2.876, p = 0.411). (3) No relationship was found between Kazawa staging of the MD-affected ear and Ménière’s stage (H = 2.679, p = 0.444), EcochG ($${x}^{2}$$

x

2

= 0.827, p = 0.867) and caloric test ($${x}^{2}$$

x

2

= 4.116, p = 0.248).

Conclusions
In patients with unilateral MD, the configuration of vascular loops in CPA-IAC region, measured by Kazawa criteria, did not correlate with the laterality, clinical stage, the results of EcochG and caloric test, suggesting that vascular loops may be natural anatomical variations for patients with MD.
A critical appraisal of the ISGLS definition of biliary leakage after liver resection
Authors: Sliwinski Svenja , Heil Jan , Franz Josephine , El Youzouri Hanan , Heise Michael , Bechstein Wolf O. , Schnitzbauer Andreas A. 
Published: February 2023

Abstract
Purpose
The International Study Group of Liver Surgery (ISGLS) defined post-hepatectomy biliary leakage as drain/serum bilirubin ratio > 3 at day 3 or the interventional/surgical revision due to biliary peritonitis. We investigated the definition’s applicability.

Methods
A retrospective evaluation of all liver resections over a 6-year period was performed. ROC analyses were performed for drain/serum bilirubin ratios on days 1, 2, and 3 including grade A to C (analysis I) and grade B and C biliary leakages (analysis II) to test specific cutoff values.

Results
A total of 576 patients were included. One hundred nine (18.9%) postoperative bile leakages occurred (19.6% of the whole population grade A, 16.5% grade B/C). Areas under the curve (AUC) for analysis I were 0.841 (day 1), 0.846 (day 2), and 0.734 (day 3). The highest sensitivity (78% on day 1/77% on day 2) and specificity (78% on day 1/79% on day 2) in analysis I were obtained for a drain/serum bilirubin ratio of 2.0. AUCs for analysis II were similar: 0.788 (day 1), 0.791 (day 2), and 0.650 (day 3). The highest sensitivity (73% on day 1/71% on day 2) and specificity (74% on day 1/76% on day 2) in analysis II were detected for a drain/serum bilirubin ratio of 2.0 on postoperative day 2.

Conclusion
Biliary leakages should be defined if the drain/serum bilirubin ratio is > 2.0 on postoperative day 2.
Efficacy of auriculotherapy in the control of pain, edema, and trismus following surgical extraction of the lower third molars: a split-mouth, randomized, placebo-controlled, and triple-blind study
Authors: Vaira Luigi Angelo , Massaiu Andrea , Massaiu Giuseppe , Salzano Giovanni , Maglitto Fabio , Lechien Jerome R. , Biglio Andrea , Visaloco Giulio , Piombino Pasquale , Biglioli Federico , De Riu Giacomo 
Published: February 2023

Abstract
Background
The aim of this split-mouth, randomized, placebo-controlled, and triple-blind study was to evaluate whether auriculotherapy had any effect on the post-operative course after the extraction of third molars in terms of the control of pain, edema, and trismus.

Materials and methods
The study included 42 patients (84 teeth) who had undergone a surgical extraction of the lower third molars. In each patient, the two extractions were randomly assigned to two study groups. In the therapy group, the patients underwent auriculotherapy with vaccaria seeds applied with patches in 6 ear points. In the control group, the patches were applied, without seeds, to the same ear points. After the extraction, the patients were asked to stimulate the ear points three times a day and whenever they felt pain. The patients were asked to keep a diary in which they assessed their pain by means of the Visual Analog Scale (VAS) for 8 days. Edema and trismus were assessed 1, 2, 3, and 8 days after surgery.

Results
The differences between the two groups were statistically significant at the 12-h control (auriculotherapy group (AG) VAS 5.5 [IQR 4.25–6.75], placebo group (PG) VAS 6 [IQR 5–8], p = 0.040), after 24 h (AG VAS 5 [IQR 4–6], PG VAS 6 [IQR 4.25–7], p = 0.024), after 2 days (AG VAS 4 [IQR 3–5], PG VAS 4.5 [IQR 4–6], p = 0.044), and after 3 days (AG VAS 3 [IQR 0–5], PG VAS 4 [IQR 3–5], p = 0.024). Throughout the observation period, the AG took a significantly lower number of painkillers than the PG (AG 6 [IQR 4.25–7]; PG 8 [IQR 8–9], p < 0.001). There were no significant differences in the levels of edema and trismus between the two groups throughout the observation period.

Conclusions
On the basis of the results of the present study, auriculotherapy can be considered as a cost-effective adjuvant pain reliever treatment in patients undergoing an extraction of the lower third molars.
Economic and environmental impact of electric vehicles production in Indonesia
Authors: Pirmana Viktor , Alisjahbana Armida Salsiah , Yusuf Arief Anshory , Hoekstra Rutger , Tukker Arnold 
Published: February 2023

AbstractThe use of fossil fuel-based vehicles may gradually be replaced by electric vehicles in the future. The trend indicates that the number of users of electric vehicles, especially electric cars, continues to increase. Indonesia is well-positioned to take advantage of this opportunity as it has the world’s largest nickel reserves, an essential raw material for making electric vehicle batteries (EVB). The study examines the economic and environmental implications if Indonesia were to successfully set up electric vehicle (EV) production rather than exporting such raw materials overseas. We use an input–output model to estimate electric vehicle production’s economic and environmental impacts in Indonesia. This study assumes that nickel, which is usually exported, is absorbed by domestic economic activities, including being used in manufacturing batteries and electric vehicles in Indonesia. Our estimates include direct and indirect output, value-added, and employment changes. The same model is also used to estimate changes in emissions’ environmental costs. It is evident from the results that batteries and EV production are economically beneficial. Additional value-added is Rp. 100.57 trillion, 1.5% of GDP in 2010. At the same time, 538,658 additional jobs were created, which is about a 0.5% increase. Lastly, EV production will have extra external costs of emissions, around Rp. 2.23 trillion, or an increase of about 0.6%. Based on these findings, it is concluded that electric vehicle production increases productivity, gross value-added, and job creation with a relatively small impact on the environment. A limitation of this study is that we assumed EVs were produced for export only, and we did not assume a reduction in economic activities in the supply chain of conventional vehicles.
Graphical Abstract
Economic and Environmental Impact of Electric Vehicles Production in Indonesia.
Is there a role for microbiome-based approach in common variable immunodeficiency?
Authors: Poto Remo , laniro Gianluca , de Paulis Amato , Spadaro Giuseppe , Marone Gianni , Gasbarrini Antonio , Varricchi Gilda 
Published: February 2023

AbstractCommon variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low levels of serum immunoglobulins and increased susceptibility to infections, autoimmune disorders and cancer. CVID embraces a plethora of heterogeneous manifestations linked to complex immune dysregulation. While CVID is thought to be due to genetic defects, the exact cause of this immune disorder is unknown in the large majority of cases. Compelling evidences support a linkage between the gut microbiome and the CVID pathogenesis, therefore a potential for microbiome-based treatments to be a therapeutic pathway for this disorder. Here we discuss the potential of treating CVID patients by developing a gut microbiome-based personalized approach, including diet, prebiotics, probiotics, postbiotics and fecal microbiota transplantation. We also highlight the need for a better understanding of microbiota-host interactions in CVID patients to prime the development of improved preventive strategies and specific therapeutic targets.
Potential use of Sargassum muticum as source of plant biostimulants after three different drying methods
Authors: Baltrusch K. , Flórez-Fernández N. , Illera M. , Torres M. D. , López-Mosquera M. E. , Domínguez H. 
Published: February 2023

AbstractSeaweed derived biostimulants are gaining attention as an important tool in sustainable agriculture. This offers a unique opportunity to alleviate the environmental impact ofSargassum muticum(Ochrophyta, Phaeophyceae) as an invasive species by finding new applications for its biomass. In this sense, incorporating green extraction technologies is fundamental to ensure environmental-friendly goals. This research was initiated in an attempt to contribute to an integral valorization system ofS. muticumbiomass, exploring the biostimulant potential of the solubles obtained from pressed solids, through an autohydrolysis treatment. In addition, we compared the effect of three different liquid phase drying techniques (spray-drying, freeze-drying and convective air-drying). Low stress drying techniques as spray-drying showed better conservation of bioactive compounds and biostimulant potential. A bioassay withNastrium officinaleshowed no phytotoxic effects despite high electric conductivity in most of the extracts and concentrations. Dried extracts showed mainly an amorphous structure but occasional crystal formation when spray-dried at low temperatures (Tout = 50 ºC) and after convective air drying (T = 40 ºC). Significant increases in root development were achieved at a concentration of 5 mg L−1of spray-dried extracts and 50 mg L−1in case of freeze-dried extracts. Munoo-Liisa vitality index showed best results with 50 mg L−1of freeze-dried extracts. This study provides important information about the influence of different drying techniques on the physicochemical properties and biostimulant potential ofS. muticumaqueous extracts and contributes to the integral valorization of its biomass.
Role of Superconducting Materials in the Endeavor to Stop Climate Change and Reach Sustainable Development
Authors: Muralidhar M. , Srikanth A. Sai , Pinmangkorn S. , Santosh M. , Milos J. 
Published: February 2023

AbstractProgress in the mass production of newly developed bulk (Gd0.33Y0.13Er0.53)Ba2Cu3Oy “(Gd,Y,Er)123” and MgB2 systems is presented. Two batches of (Gd,Y,Er)123 pellets of 20 mm diameter and 7 mm thick were prepared in air by an infiltration growth “IG” process. Trapped field distribution profiles of fully grown bulk samples clearly showed that all samples were single-grain and the trapped field values were more than 0.5 T at 77 K, 1.3 mm above top surface. The best bulk exhibited the trapped field value of 0.63 T at 77 K. Ultra-sonication technique was employed for refining precursors of both (Gd,Y,Er)211 and boron. TEM studies revealed that boron powder subjected to ultrasonication was refined up to nanoscale. The micron-sized particles were reduced to nanoscale, which led to improvement of critical current by up to 36% in bulk MgB2 at 20 K and self-field. This progress in fabrication of high-performance LREBa2Cu3Oy and MgB2 superconducting bulks further promotes commercialization of superconductors’ production as a mode of sustainable technology.
Lipid Nanoparticles for Nucleic Acid Delivery to Endothelial Cells
Authors: Liu Gary W. , Guzman Edward B. , Menon Nandita , Langer Robert S. 
Published: February 2023

AbstractEndothelial cells play critical roles in circulatory homeostasis and are also the gateway to the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells can cause, or are caused by, prevalent chronic diseases such as diabetes, cardiovascular disease, and cancer. Modulation of gene expression within endothelial cells could therefore be therapeutically strategic in treating longstanding disease challenges. Lipid nanoparticles (LNP) have emerged as potent, scalable, and tunable carrier systems for delivering nucleic acids, making them attractive vehicles for gene delivery to endothelial cells. Here, we discuss the functions of endothelial cells and highlight some receptors that are upregulated during health and disease. Examples and applications of DNA, mRNA, circRNA, saRNA, siRNA, shRNA, miRNA, and ASO delivery to endothelial cells and their targets are reviewed, as well as LNP composition and morphology, formulation strategies, target proteins, and biomechanical factors that modulate endothelial cell targeting. Finally, we discuss FDA-approved LNPs as well as LNPs that have been tested in clinical trials and their challenges, and provide some perspectives as to how to surmount those challenges.