bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seduction
Authors: Dorsey Bruce 
Published: July 2023

Abstract
Rather than confronting the crime of rape at the heart of Cornell’s accusation against Avery, Americans prefer to explain this scandal with the familiar plot of a seduction story, like the contemporary novels they voraciously read. Seduction becomes the catch-all term to explain any form of deceitful or coerced sexual liaisons. Seduction also touches Americans’ deeper anxieties about the changing world around them, especially the problem of how to live a moral life in an economic and political environment in which deceit and hypocrisy prevail. In most people’s minds, Maria Cornell had in fact been seduced, but who or what was the author of her seduction remains uncertain. Even so, the notion of Avery as a seducer returns once more in a post-trial controversy over an artistic rendering of the Methodist preacher.
Rethinking Meditation
Authors: McMahan David L. 
Published: July 2023

Abstract
Rethinking Meditation provides a new theoretical and historical approach to Buddhist and Buddhist-derived meditative practices. It shows how, rather than coming down to us unchanged from the time of the Buddha, the standard articulation of mindfulness as bare, nonjudgmental attention to the present moment is a distillation of particular strands of classical Buddhist thought that have combined with western ideas to create a unique practice tailored to modern forms of thought and ways of life. Part genealogical study and part philosophical argument, it inquires into some of the widespread assumptions about how meditation works and what it does, presenting a view of meditative practices as technologies of the self embedded in cultural forms of life. It shows that the relationship between meditative practices and cultural context is much more crucial than is suggested in typical contemporary articulations, which often emphasize transcendence of cultural conditioning and achieving “objective” internal access to the contents of consciousness. Meditation, McMahan argues, is always situated in social contexts and draws from repertoires of cultural categories, concepts, and values, sometimes accommodating them and sometimes resisting them. Rethinking Meditation also considers the scientific study of meditation and meditation in relation to modern articulations of secularism, freedom, authenticity, appreciation, and interdependence. It also examines the potential for meditation to enhance autonomy and addresses recent attempts to bring meditative practices to bear on social, political, and environmental issues.
Introduction
Authors: McMahan David L. 
Published: July 2023

Abstract
Among the vast variety of meditation practices that have been developed in the Buddhist tradition, one has become ubiquitous: the nonjudgmental attention to the present moment, which this chapter calls the Standard Version of meditation. This chapter lays out some of the themes of the book, introducing this practice as something that, rather than going unambiguously back to the time of the Buddha, has been shaped by modern cultural “magnets,” which draw particular compelling elements of the Buddhist tradition, and “filters,” which sift out elements less compatible with modern and contemporary assumptions. It lays out the theoretical argument for the importance of cultural context in meditative practices and anticipates some of the historical precedents for the Standard Version and how it came to be against the backdrop of secularism and other dominant ways of thinking today.
Neural Maps and Enlightenment Machines
Authors: McMahan David L. 
Published: July 2023

Abstract
The scientific study of meditation often contains implicit views of the human being as a free, autonomous subject who can be trained to neutralize biases, presuppositions, and cultural conditioning to attain judgment-free access to the raw data of the mind. It combines a “theater-of-the-mind” model of the mind with a concept of human beings as “cerebral subjects” whose internal mental states can be modeled by brain-imaging technologies. Both of these perspectives tend to neglect the crucial role of cultural and social context. Rather than seeing meditation primarily in terms of interior mental states that can be mapped in neural imaging technologies, meditation or mindfulness might be better understood as a set of situated, embodied skills involving the cultivation of attitudes, ethical orientations, values, judgments, strategies, and behaviors in systemic relationship with particular cultural worlds.
What Difference Does Context Make?
Authors: McMahan David L. 
Published: July 2023

Abstract
This chapter develops the idea of meditative practices as technologies or practices of self within particular social imaginaries constituted by repertoires of concepts, attitudes, social practices, customs, ethical dispositions, institutions, power relations, and structures of authority. Such practices are not only a matter of self-awareness but also self-cultivation and self-formation as an ethical subject. Meditation within particular social imaginaries means pursuing particular ethical goals and acting according to culturally available concepts and values. Seeing meditative practices this way makes it harder to assert that they will have the same effects on people in radically different social imaginaries. Imagining the stark contrast between the lived worlds of an ancient Buddhist monk and a contemporary businesswoman illustrates the different kinds of subjectivity that similar meditation practices can be called on to help cultivate.
Meditation in the Pali Social Imaginary I
Authors: McMahan David L. 
Published: July 2023

Abstract
This chapter brings early Buddhist meditation literature—especially the Satipaṭṭhāna Sutta—into conversation with ideas in phenomenology and cognitive science that address the distinction between conscious, effortful activity and habitual activity rooted in the tacit assumptions, dispositions, and categories of a particular cultural context. Some meditation practices disrupt the tacit level of experience in order to bring it to explicit cognition and intentional direction. Part of their original purpose was to help consciously cultivate particular ways of being in the world for Buddhist monastics and to habituate them to the categories, orientations, and sensibilities recommended for monastic life, fostering explicit awareness of the habitual flow of experience and activity in order to reconfigure this activity and reinterpret its significance. Meditation in this sense entails training desires, aesthetic sensibilities, and categories through which to interpret one’s experience, creating an alternative habitus—a habitual, embodied way of being in the world.
Affordances, Disruption, and Activism
Authors: McMahan David L. 
Published: July 2023

Abstract
Thinking of meditative practices as providing opportunities to put a variety of affordances into play while resisting or rejecting other affordances allows us to think with more precision about the Situated Autonomy model of meditation. On this interpretation, autonomy contains a dynamic tension between denial, affirmation, and reinterpretation of features of the internal affordance landscape brought into greater focus by reflexive, introspective practice. Such practices create a sense of greater autonomy in that they bring about a level of heightened, thematic awareness, inducing explicit consciousness of what is normally implicit, and offering expanded opportunities to refuse, pursue, and reinterpret cultural, moral, and interpretive affordances according to a particular ethical or philosophical vision. The ethical dimensions of contemporary forms of meditation have recently been extended beyond the search for interior liberation and brought to bear on external barriers to autonomy, such as oppressive social structures or environmental threats.
Natural variation in OsSEC13 HOMOLOG 1 modulates redox homeostasis to confer cold tolerance in rice
Authors: Gu Shuang , Zhang Zhe , Li Jinquan , Sun Jian , Cui Zhibo , Li Fengcheng , Zhuang Jia , Chen Wanchun , Su Chang , Wu Lian , Wang Xiaoliang , Guo Zhifu , Xu Hai , Zhao Minghui , Ma Dianrong , Chen Wenfu 
Published: July 2023

Abstract
Rice (Oryza sativa L.) is a cold-sensitive species that often faces cold stress, which adversely affects yield productivity and quality. However, the genetic basis for low-temperature adaptation in rice remains unclear. Here, we demonstrate that 2 functional polymorphisms in O. sativa SEC13 Homolog 1 (OsSEH1), encoding a WD40-repeat nucleoporin, between the 2 subspecies O. sativa japonica and O. sativa indica rice, may have facilitated cold adaptation in japonica rice. We show that OsSEH1 of the japonica variety expressed in OsSEH1MSD plants (transgenic line overexpressing the OsSEH1 allele from Mangshuidao [MSD], cold-tolerant landrace) has a higher affinity for O. sativa metallothionein 2b (OsMT2b) than that of OsSEH1 of indica. This high affinity of OsSEH1MSD for OsMT2b results in inhibition of OsMT2b degradation, with decreased accumulation of reactive oxygen species and increased cold tolerance. Transcriptome analysis indicates that OsSEH1 positively regulates the expression of the genes encoding dehydration-responsive element-binding transcription factors, i.e. OsDREB1 genes, and induces the expression of multiple cold-regulated genes to enhance cold tolerance. Our findings highlight a breeding resource for improving cold tolerance in rice.
Identifying a Lung Stem Cell Subpopulation by Combining Single-Cell Morphometrics, Organoid Culture, and Transcriptomics
Authors: Fujimura Takashi , Enomoto Yasunori , Katsura Hiroaki , Ogawa Taisaku , Baba Saori , Ogata Akira , Yamaoka Akira , Shiroguchi Katsuyuki , Morimoto Mitsuru 
Published: July 2023

Abstract
Single-cell RNA sequencing is a valuable tool for dissecting cellular heterogeneity in complex systems. However, it is still challenging to estimate the proliferation and differentiation potentials of subpopulations within dormant tissue stem cells. Here, we established a new single-cell analysis method for profiling the organoid-forming capacity and differentiation potential of tissue stem cells to disclose stem cell subpopulations by integrating single-cell morphometrics, organoid-forming assay, and RNA sequencing, a method named scMORN. To explore lung epithelial stem cells, we initially developed feeder-free culture system, which could expand all major lung stem cells, including basal, club, and alveolar type 2 (AT2) cells, and found that club cells contained a subpopulation, which showed better survival rate and high proliferation capacity and could differentiate into alveolar cells. Using the scMORN method, we discovered a club cell subpopulation named Muc5b+ and large club (ML-club) cells that efficiently formed organoids than other club or AT2 cells in our feeder-free organoid culture and differentiated into alveolar cells in vitro. Single-cell transcriptome profiling and immunohistochemical analysis revealed that ML-club cells localized at the intrapulmonary proximal airway and distinct from known subpopulations of club cells such as BASCs. Furthermore, we identified CD14 as a cell surface antigen of ML-club cells and showed that purified CD14+ club cells engrafted into injured mouse lungs had better engraftment rate and expansion than other major lung stem cells, reflecting the observations in organoid culture systems. The scMORN method could be adapted to different stem cell tissues to discover useful stem-cell subpopulations.
Cytomegalovirus in biliary atresia is associated with increased pretransplant death, but not decreased native liver survival
Authors: Kemme Sarah , Canniff Jennifer D. , Feldman Amy G. , Garth Krystle M. , Li Shaobing , Pan Zhaoxing , Sokol Ronald J. , Weinberg Adriana , Mack Cara L. 
Published: July 2023

Background:
Biliary atresia (BA) is likely caused by a common phenotypic response to various triggers; one proposed trigger, cytomegalovirus (CMV), may lead to worse outcomes. The aim of this study was to determine the severity of disease and pretransplant outcomes of infants with BA, who have evidence of CMV (CMV+) at diagnosis compared with CMV-negative (CMV−) infants.

Methods:
The study used data and biospecimens from the Childhood Liver Disease Research Network PROBE study of cholestatic infants. Plasma obtained at the time of hepatic portoenterostomy (HPE) of 249 infants with BA was tested for CMV by DNA-PCR and CMV-IgM. Comparisons between CMV+ and CMV− infants were made using Wilcoxon rank sum, Student t test, chi-square, or Fisher exact test. Native liver survival (NLS) outcomes were analyzed using Kaplan-Meier and Cox regression adjusting for age at HPE; pretransplant patient survival outcomes were analyzed using a competing risk model and adjusting for age at HPE.

Results:
CMV+ infants (n = 29, 12%) underwent HPE later (67.8±13.6 d vs. 55.1±18.5 d, p = 0.0005) and had higher baseline alkaline phosphatase and aminotransferases. There was no difference between groups in jaundice clearance or NLS. The subdistribution HR of pretransplant death for CMV+ infants adjusted for age at HPE was 3.8 (p = 0.034).

Conclusions:
CMV infection at the time of HPE in infants with BA is not associated with worse NLS despite the association with worse liver injury, older age at HPE, and increased risk of pretransplant death adjusted for age at HPE. Continued evaluation of the consequences of CMV infection and the effects of antiviral treatment should be explored.
The Current Role of Human Papillomavirus Circulating Tumor DNA in Oropharynx Cancer
Authors: Regan Samuel N. , Mierzwa Michelle L. 
Published: July 2023

Abstract
Human papillomavirus infection is currently implicated in the majority of oropharyngeal squamous cell carcinoma cases diagnosed in the United States. Circulating tumor DNA (ctDNA) has emerged as a potential biomarker for human papillomavirus–related oropharyngeal squamous cell carcinoma and has the opportunity to improve the diagnosis, treatment, and surveillance of patients with this disease. Changes in ctDNA levels during and after primary therapy may be related to disease response, which can possibly have implications for treatment intensification or de-escalation strategies. Further, ctDNA seems to be sensitive and specific for disease recurrence and may improve upon current methods for assessing both treatment response and failure. In this review, we examine the relevant literature on the use of ctDNA for oropharyngeal cancer treatment and surveillance and discuss current limitations and future directions for this promising biomarker.
Circulating Tumor DNA in Human Papillomavirus–Mediated Oropharynx Cancer
Authors: Heft Neal Molly E. , Walline Heather M. , Haring Catherine T. 
Published: July 2023

Abstract
Circulating tumor DNA (ctDNA) has become an area of intense study in many solid malignancies including head and neck cancer. This is of particular interest for human papillomavirus–mediated oropharyngeal squamous cell carcinoma as this cohort of patients has excellent survival and is undergoing current clinical trials aimed at treatment de-escalation. Recent studies have demonstrated the prognostic implications of pretreatment ctDNA and the utility of monitoring ctDNA during and posttreatment; however, there is a need for a more critical understanding of ctDNA as it is beginning to be incorporated into clinical trials. This review discusses the current state of ctDNA in oropharynx cancer focusing on ctDNA kinetics and minimal residual disease detection and ends with a discussion of future applications.
Corporate social responsibility, business strategy and governance performance
Authors: Elmassri Moataz , Kuzey Cemil , Uyar Ali , Karaman Abdullah S. 
Published: July 2023

PurposeThis study aims to examine the effect of corporate social responsibility (CSR) adoption on differentiation and cost leadership strategies and how governance structure moderates this CSR–strategy relationship.Design/methodology/approachThe study data were retrieved from Thomson Reuters for non-financial firms between 2013 and 2019, and a fixed-effects panel regression analysis was executed.FindingsThe results indicate that CSR fosters cost leadership strategy but weakens differentiation strategy. This result supports the value generation school for cost leaders but also confirms the agency theory perspective for differentiators. Moreover, the governance structure does not moderate the relationship between a firm's CSR engagement and its business strategy, which implies a lack of corporate policies that concurrently consider both its CSR investment and strategies.Research limitations/implicationsThe findings of this study imply that cost leaders can integrate CSR practices into their business strategy and use their CSR engagement to increase their competitive position by stimulating cost efficiency and creating greater turnover. On the contrary, for differentiators, there is a trade-off between environmental and social engagement and business strategies. Thus, they are advised to enrich their unique product development abilities through the integration of environmental and social practices and reinforce their competitive position by addressing stakeholders' interests. The practical implication of the moderation analysis is that there is no rooted corporate policy behind the connection between CSR and firm strategy for both cost leaders and differentiators, which constitutes a missing link.Originality/valueThe findings of this study are of critical importance for firms, offering justification for the integration of two vital perspectives: social and environmental sustainability and financial sustainability. The moderating effect of governance performance tests the upper echelon's role in maintaining both sustainability perspectives concurrently and strengthening the legitimacy of the firms in society. Although maintaining a business strategy is important for shareholders' interests, pursuing a social and environmental sustainability strategy is crucial for meeting the expectations of all stakeholders.
Proposal of nursing diagnosis “adult disuse syndrome”: A conceptual derivation and integrative review
Authors: Ardila Suárez Edinson Fabian , Escalada‐Hernández Paula 
Published: July 2023

AbstractPurposeTo develop a nursing diagnosis proposal derived from the concept of “disuse syndrome” based on an integrative review.MethodsThe conceptual derivation technique, proposed by Walker and Avant, was used in the following phases: an integrative review of the literature was carried out, applying the parameters of Whitermore and Knalf, where 43 articles were selected that covered the existence of the concept in the nursing discipline and other health sciences, the concepts were subsequently analyzed, and the new concept was redefined following the middle‐range theory of causality and validation of nursing diagnoses proposed by Oliveira‐Lopes et al.FindingsThe proposal of the new nursing diagnosis was developed, including the following elements: diagnostic label adult disuse syndrome, the corresponding definition, 25 defining characteristics, eight related factors, eight risk populations, and 14 associated problems.ConclusionsThe concept of the proposed new diagnosis describes adult disuse syndrome as a phenomenon that transcends the physiological component and should be viewed from a multidimensional view, expressing a clinical judgment related to a series of nursing diagnoses that appear together.Implications for nursing practiceThe results of this study will help nursing professionals to identify the phenomenon of adult disuse syndrome in any setting and in turn guide optimal care interventions that decrease the consequences of adult disuse syndrome.
Comorbid alcohol use disorder and posttraumatic stress disorder: A proof‐of‐concept randomized placebo‐controlled trial of buprenorphine and naltrexone combination treatment
Authors: Davis Lori L. , Petrakis Ismene L. , Pilkinton Patricia D. , Nolen Tracy , Vandergrift Nathan , Hirsch Shawn , Norrholm Seth D. , Kosten Thomas R. 
Published: July 2023

AbstractBackgroundEffective pharmacologic treatments for comorbid alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are lacking. Kappa (κ) opioid receptor antagonists may address this unmet need. Buprenorphine is a κ‐opioid antagonist and a partial agonist of mu (μ) opioid receptors. Whereas naltrexone blocks all μ‐mediated effects combining it with buprenorphine yields a pharmacologic net effect of opioid receptor antagonism. Because no κ‐opioid receptor antagonist it available for clinical use, we tested this combination in a proof‐of‐concept study.MethodsConsenting participants were enrolled in a Phase II, multisite, double‐blind, randomized, placebo‐controlled trial evaluating the effectiveness of sublingual (SL) buprenorphine combined with extended‐release (XR) injectable naltrexone for the treatment of comorbid AUD and PTSD. Eligible participants (n = 75) were randomized (1:1:1) to receive either buprenorphine 2 mg/day plus naltrexone‐XR (n = 35), buprenorphine 8 mg/day plus naltrexone‐XR (n = 6) or SL plus injectable placebo (n = 34) for 12 weeks. The buprenorphine 8 mg/day plus naltrexone‐XR arm was dropped early in the trial due to the negative impact of COVID‐19 on enrollment. A binary primary outcome of response at week 8 was defined as a decrease from baseline of ≥10 points on the past week Clinician‐Administered PTSD Scale (CAPS‐5) and a reduction of ≥1 of past month alcohol risk level, as defined by the World Health Organization (WHO) and measured by the Timeline Follow‐Back.ResultsBased on the results of a futility analysis, enrollment was stopped prior to reaching the initial goal of 90 participants. At the week eight primary timepoint, there were no statistically significant differences between buprenorphine plus naltrexone‐XR and placebo group for the primary composite outcome (OR = 0.63; p‐value = 0.52), or the subcomponents of the PTSD outcome (OR = 0.76; p‐value = 0.69) and AUD outcome (OR = 0.17; p‐value = 0.08). The placebo arm had a significantly higher proportion of participants with ≥1 WHO risk level reduction than the buprenorphine plus naltrexone‐XR arm (OR = 0.18, p value = 0.02).ConclusionsThis is the first study to evaluate the potential of κ‐opioid receptor antagonism for the treatment of comorbid AUD and PTSD. The combination of buprenorphine and naltrexone‐XR showed no significant improvement over placebo for the composite, PTSD, or alcohol measures.