bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probing the mechanism of neutrinoless double-beta decay in multiple isotopes
Authors: Agostini Matteo , Deppisch Frank F. , Van Goffrier Graham 
Published: February 2023

Abstract
A large experimental program is being mounted to search for neutrinoless double-beta decay over the next decade. Multiple experiments using different target isotopes are being prepared to explore the whole parameter space allowed for inverted-ordered light neutrinos, and have the potential to make discoveries in several other scenarios, including normal-ordered light neutrinos and other exotic mechanisms. We investigate to what extent long-range and exotic short-range contributions may be distinguished by combining measurements of the decay half-life across isotopes in the framework of a global Bayesian analysis. We demonstrate how measurements in two isotopes will constrain the parameter space up to a two-fold degeneracy, and how a further measurement in a third isotope removes such a degeneracy. We also discuss the impact of uncertainties and correlations in nuclear matrix element calculations. Our work motivates an experimental program measuring neutrinoless double-beta decay in more than one isotope, as this would break parameter degeneracies and advance our understanding of particle physics beyond the Standard Model.
Combined Conduit Score in Contrast-Enhanced Magnetic Resonance Venography in Patients with Idiopathic Intracranial Hypertension
Authors: Elsaid Nada , Razek Ahmed , Batouty Nihal M. , Elmokadem Ali H , Tawfik Ahmed M. , Saied Ahmed 
Published: February 2023

Abstract
Background
Based on increased understanding of the idiopathic intracranial hypertension (IIH) pathophysiology, venous sinus stenting (VSS) has emerged as an effective treatment for patients with transverse sinus stenosis (TSS). The presence of a reliable TSS screening tool is warranted. The combined conduit score (CCS) is the most widely used score for evaluation of the cerebral sinovenous stenosis in contrast-enhanced magnetic resonance venography (CE-MRV).

Purpose of the Study
To evaluate the interobserver agreement between neuro-interventionalists and radiologists with respect to the CCS in evaluation of transverse sinus stenosis in patients with idiopathic intracranial hypertension using CE-MRV.

Methods
A retrospective study was conducted on 26 consecutive patients diagnosed with IIH and underwent CE-MRV. The 2 neuro-interventionalists and 2 radiologists separately evaluated the cerebral venous sinuses using the CCS.

Results
The mean CCS was significantly different between the neuro-interventionalists and radiologists (p < 0.001), higher for the radiologists. The inter-rater reliability was excellent (ICC = 0.954, 95% CI: 0.898–0.979) between the 2 neuro-interventionalists, good between the 2 radiologists (ICC = 0.805, 95% CI: 0.418–0.921), but was not acceptable between the neuro-interventionalists and the radiologists (ICC 0.47 95% CI:−2.2–0.782).

Conclusion
Despite the excellent agreement between the neuro-interventionists and the good agreement between the radiologists, there was no agreement between the neuro-interventionists and the radiologists. Our finding suggests that there is a gap between the 2 specialties but does not favor any of them. Factors related to the observers, the venous sinus system, the MRV or the CCS score may have resulted in this discrepancy. Automatic or semi-automatic feature extractions to produce quantifiable biomarkers for IIH are warranted. The clinical decisions should not depend only on strongly observer-dependent scores with training and/or experience-dependent influences.
Depression im Alter und Frailty – epidemiologische, klinische und neurobiologische Zusammenhänge
Authors: Depping M. S. , Köhler-Ipek L. , Ullrich P. , Hauer K. , Wolf R. C. 
Published: February 2023

Zusammenfassung
Hintergrund
Depression ist beim alten Menschen die häufigste psychische Störung und wird durch geriatrietypische Morbidität beeinflusst. Die Komorbidität mit „Frailty“ ist besonders relevant. Frailty ist von zentraler Bedeutung in der modernen Altersmedizin und zeigt die belastungsabhängige Vulnerabilität eines alten Menschen sowie sein erhöhtes Risiko von Behinderung, Hospitalisierung und Tod an. Es kommt der Diagnostik und Behandlung von Depression im Alter zugute, sich mit den Zusammenhängen mit Frailty auseinanderzusetzen, auch auf neurobiologischer Ebene.

Ziel der Arbeit
Dieses narrative Review gibt einen Überblick über die Komorbidität von Depression im Alter und Frailty, mit einem Schwerpunkt auf neurowissenschaftlichen Erkenntnissen, die anhand des Research-Domain-Criteria(RDoC)-Ansatzes systematisiert werden.

Ergebnisse
Frailty findet sich komorbid bei mehr als einem Drittel der Patienten mit Depression im Alter, was mit kritischen Depressionsverläufen und mit schlechterer Wirksamkeit und Verträglichkeit antidepressiver Medikation verbunden ist. Depression und Frailty teilen motivationale und psychomotorische Merkmale, speziell Antriebsminderung, erhöhte Erschöpfbarkeit und verringerte körperliche Aktivität. Bei Frailty sind funktionelle Veränderungen in bewegungsvorbereitenden neuronalen Arealen mit motorischen Leistungseinschränkungen assoziiert. Bei Depression im Alter mit Apathie finden sich abnorme Struktur und veränderte funktionelle Konnektivität des Belohnungs- und des Salienznetzwerks, außerdem veränderte funktionelle Konnektivität dieser Netzwerke mit prämotorischen Arealen.

Diskussion
Es ist prognostisch und therapeutisch relevant, Frailty bei Alterspatienten mit Depression zu erkennen. Die (Weiter‑)Entwicklung und Individualisierung von Therapien für diese vulnerable Patientengruppe wird auch davon profitieren, sich auf neuronale Mechanismen der Komorbidität zu beziehen.
Stress memory and its regulation in plants experiencing recurrent drought conditions
Authors: Kambona Carolyn Mukiri , Koua Patrice Ahossi , Léon Jens , Ballvora Agim 
Published: February 2023

AbstractDeveloping stress-tolerant plants continues to be the goal of breeders due to their realized yields and stability. Plant responses to drought have been studied in many different plant species, but the occurrence of stress memory as well as the potential mechanisms for memory regulation is not yet well described. It has been observed that plants hold on to past events in a way that adjusts their response to new challenges without altering their genetic constitution. This ability could enable training of plants to face future challenges that increase in frequency and intensity. A better understanding of stress memory-associated mechanisms leading to alteration in gene expression and how they link to physiological, biochemical, metabolomic and morphological changes would initiate diverse opportunities to breed stress-tolerant genotypes through molecular breeding or biotechnological approaches. In this perspective, this review discusses different stress memory types and gives an overall view using general examples. Further, focusing on drought stress, we demonstrate coordinated changes in epigenetic and molecular gene expression control mechanisms, the associated transcription memory responses at the genome level and integrated biochemical and physiological responses at cellular level following recurrent drought stress exposures. Indeed, coordinated epigenetic and molecular alterations of expression of specific gene networks link to biochemical and physiological responses that facilitate acclimation and survival of an individual plant during repeated stress.
Enlarging the Arsenal of Test Species for Sediment Quality Assessment
Authors: Wieringa N. , Droge S. T. J. , Bakker A. M. , Melkert R. A. , Prast B. J. , Verdonschot P. F. M. , Kraak M. H. S. 
Published: February 2023

AbstractSince only a few standard benthic test species are available for sediment quality, our study aimed to employ multiple test species representing different sensitivity categories in the quality assessment of contaminated sediments. To this end three macroinvertebrate species, Sericostoma personatum (caddisfly, sensitivity category 10), Asellus aquaticus (isopod, category 3) and Chironomus riparius (chironomid, category 2), were exposed to sediments originating from various contamination sources in whole sediment bioassays using intact sediment cores. The agricultural sediment caused insect mortality, the agricultural and urban sediment caused isopod growth reduction and the urban and Wastewater Treatment Plant (WWTP) sediment affected chironomid emergence time. It is concluded that the arsenal of standard species can be successfully expanded by non-standard species, reducing over- or underestimation of the risks of contaminated sediments.
Retrospective analysis of apical prolapse correction by unilateral pectineal suspension: perioperative and short-term results
Authors: Bolovis Dimitrios Ilias , Schreibmayer Michael , Hitzl Wolfgang , Brucker Cosima Veronika Maria 
Published: February 2023

Abstract
Introduction and hypothesis
We have previously published the novel method of unilateral pectineal suspension (UPS) for apical prolapse correction. UPS provides mesh-free midline uterus suspension using a single non-absorbable suture to attach the anterior cervix to the lateral part of the iliopectineal ligament. The purpose of this retrospective cohort study was to analyze the short-term efficacy, perioperative complication rate, and overall patient acceptance of the new UPS surgical concept.

Methods
Forty-seven patients with POP-Q stage 2–4 who underwent robotic UPS between January 1, 2020 and December 31, 2021 were included in the study. Patient data were taken retrospectively from the patient files. Treatment success was the primary endpoint, measured both objectively using a defined composite endpoint and subjectively according to patients’ acceptance 3–6 months after surgery during a follow-up examination. Secondary outcome measures included complications and conversions, and effect of additional procedures on operative time.

Results
Treatment success as measured by the defined composite endpoint was 93.6% for the entire cohort. No complications or conversions occurred. Mean operation time for isolated UPS was 46.5 min (n = 33 patients). UPS can be easily combined with additional surgical procedures for repair of remaining pelvic floor defects, incontinence surgery or other indications. Additional procedures performed had a significant influence on operation time (p < 0.0005, n = 14).

Conclusions
UPS shows highly favorable results when looking at an unselected cohort of patients in need of primary POP surgery with respect to established quality parameters of POP repair.
Evidential requirements for the regulatory hazard and risk assessment of respiratory sensitisers: methyl methacrylate as an example
Authors: Meek Bette , Bridges James W. , Fasey Andrew , Sauer Ursula G. 
Published: February 2023

AbstractThis review addresses the need for a framework to increase the consistency, objectivity and transparency in the regulatory assessment of respiratory sensitisers and associated uncertainties. Principal issues are considered and illustrated through a case study (with methyl methacrylate). In the absence of test methods validated for regulatory use, formal documentation of the weight-of-evidence for hazard classification both at the level of integration of individual studies within lines of evidence and across a broad range of data streams was agreed to be critical for such a framework. An integrated approach is proposed to include not only occupational studies and clinical evidence for the regulatory assessment of respiratory sensitisers, but also information on structure and physical and chemical factors, predictive approaches such as structure activity analysis and in vitro and in vivo mechanistic and toxicokinetic findings. A weight-of-evidence protocol, incorporating integration of these sources of data based on predefined considerations, would contribute to transparency and consistency in the outcome of the assessment. In those cases where a decision may need to be taken on the basis of occupational findings alone, conclusions should be based on transparent weighting of relevant data on the observed prevalence of occupational asthma in various studies taking into account all relevant information including the range and nature of workplace exposures to the substance of interest, co-exposure to other chemicals and study quality.
The influence of the texture and color of goat’s salad cheese on the emotional reactions of consumers compared to cow’s milk cheese and Feta cheese
Authors: Kaczyński Łukasz K. , Cais-Sokolińska Dorota , Bielska Paulina , Teichert Joanna , Biegalski Jakub , Yiğit Aslı , Chudy Sylwia 
Published: February 2023

AbstractIn this study, the sensory and mechanical aspects of the texture of goat’s milk salad cheese were correlated with the emotional profiles of consumers. Using descriptive sensory analysis and instrumental assessment, the texture profile of goat’s milk salad cheese was compared to cow’s milk salad cheese and Feta cheese. Texture measurements confirmed that goat’s cheese compared to cow’s cheese had more softness and less hardness, and Feta cheese had the highest whiteness index compared to the other cheeses. Goat’s milk salad cheese was much less acceptable to consumers compared to cow’s milk cheese and Feta cheese. Consumers also indicated that the hardness of goat’s cheese was lower than that of cow’s cheese and Feta cheese. A reduction in “stickiness” in comparison with cow’s cheese was also reported; however, it was much higher than that for Feta cheese. The “fracturability” and “graininess” of goat’s cheese was similar to cow’s cheese. Emotional profile analysis showed that goat’s cheese evokes mainly negative emotions. Consumers indicated only one positive emotion in the case of this cheese, which was “healthy”. The most frequently mentioned emotions after the consumption of goat’s cheese were “upset”, “disgusted” and “worried”. Many consumers also indicated “disappointed” and “angry”, which did not occur after the consumption of cow’s cheese. This research shows how important it is to combine several analyses and techniques when evaluating dairy products, including salad cheeses. It is also important that consumer research is enriched by emotional profiling.
Graphical abstract
Spatial and temporal (non)binding of audiovisual rhythms in sensorimotor synchronisation
Authors: Lapenta Olivia Morgan , Keller Peter E. , Nozaradan Sylvie , Varlet Manuel 
Published: February 2023

AbstractHuman movement synchronisation with moving objects strongly relies on visual input. However, auditory information also plays an important role, since real environments are intrinsically multimodal. We used electroencephalography (EEG) frequency tagging to investigate the selective neural processing and integration of visual and auditory information during motor tracking and tested the effects of spatial and temporal congruency between audiovisual modalities. EEG was recorded while participants tracked with their index finger a red flickering (rate fV = 15 Hz) dot oscillating horizontally on a screen. The simultaneous auditory stimulus was modulated in pitch (rate fA = 32 Hz) and lateralised between left and right audio channels to induce perception of a periodic displacement of the sound source. Audiovisual congruency was manipulated in terms of space in Experiment 1 (no motion, same direction or opposite direction), and timing in Experiment 2 (no delay, medium delay or large delay). For both experiments, significant EEG responses were elicited at fV and fA tagging frequencies. It was also hypothesised that intermodulation products corresponding to the nonlinear integration of visual and auditory stimuli at frequencies fV ± fA would be elicited, due to audiovisual integration, especially in Congruent conditions. However, these components were not observed. Moreover, synchronisation and EEG results were not influenced by congruency manipulations, which invites further exploration of the conditions which may modulate audiovisual processing and the motor tracking of moving objects.
ERCC6L2-related disease: a novel entity of bone marrow failure disorder with high risk of clonal evolution
Authors: Baccelli Francesco , Leardini Davide , Cerasi Sara , Messelodi Daria , Bertuccio Salvatore Nicola , Masetti Riccardo 
Published: February 2023

AbstractERCC excision repair 6 like 2 (ERCC6L2) gene encodes for different helicase-like protein members of the Snf2 family involved in transcription-coupled nucleotide excision repair and in cell proliferation. Germline homozygous mutations in children and adults predispose to a peculiar bone marrow failure phenotype characterized by mild hematological alterations with a high risk of developing acute myeloid leukemia. The outcome for patients with leukemia progression is dismal while patients undergoing hematopoietic stem cell transplantation in the early stage have better outcomes. The ERCC6L2-related hematological disease presents a high penetrance, posing important questions regarding the treatment strategies and possible preemptive approaches. This review describes the biological function of ERCC6L2 and the clinical manifestations of the associated disease, trying to focus on the unsolved clinical questions.
A systematic review of the incidence, management and prognosis of new-onset autoimmune connective tissue diseases after COVID-19
Authors: Kouranloo Koushan , Dey Mrinalini , Elwell Helen , Nune Arvind 
Published: February 2023

AbstractA literature review on new-onset autoimmune connective tissue diseases (ACTDs) following COVID-19 is lacking. We evaluated potential associations between COVID-19 and the development of new-onset ACTDs. The “population” was adults with disease terms for ACTDs, including systemic lupus erythematosus (SLE), Sjogren’s syndrome, systemic sclerosis (SSc), idiopathic inflammatory myositis (IIM), anti-synthetase syndrome, mixed CTD and undifferentiated CTD, and “intervention” as COVID-19 and related terms. Databases were searched for English-language articles published until September 2022. We identified 2236 articles with 28 ultimately included. Of the 28 included patients, 64.3% were female, with a mean age was 51.1 years. The USA reported the most cases (9/28). ACTD diagnoses comprised: 11 (39.3%) IIM (including four dermatomyositis); 7 (25%) SLE; four (14.3%) anti-synthetase syndrome; four (14.3%) SSc; two (7.1%) other ACTD (one lupus/MCTD overlap). Of eight, four (14.3%) patients (including that with lupus/MCTD) had lupus nephritis. The average time from COVID-19 to ACTD diagnosis was 23.7 days. A third of patients were admitted to critical care, one for treatment of haemophagocytic lymphohistiocytosis in SLE (14 sessions of plasmapheresis, rituximab and intravenous corticosteroids) and nine due to COVID-19. 80% of patients went into remission of ACTD following treatment, while three (10%) patients died—one due to macrophage activation syndrome with anti-synthetase syndrome and two from unreported causes. Our results suggest a potential association between COVID-19 and new-onset ACTDs, notably in young females, reflecting more comprehensive CTD epidemiology. The most common diagnosis in our cohort was IIM. The aetiology and mechanisms by which ACTDs emerge following COVID-19 remain unknown and require further research.
Cryogenic Tm:LiYF4 laser around 2 µm
Authors: Alles Adrian , Jambunathan Venkatesan , Slimi Sami , Serres Josep M. , Aguiló Magdalena , Díaz Francesc , Mateos Xavier , Smrz Martin , Mocek Tomas 
Published: February 2023

AbstractWe present the laser characteristics of a 5 at.% Tm:YLF crystal using a modular setup at cryogenic temperatures emitting around 2 µm. Continuous-wave laser operation was achieved by pumping the laser crystal using a Volume Bragg Grating-stabilized laser diode emitting at 793 nm. A maximum output power of 6.5 W was achieved at 80 K corresponding to a slope efficiency of 66.0% with respect to the absorbed power with excellent beam quality.
Positional preferences and efficiency in a dynamic economy
Authors: Aronsson Thomas , Ghosh Sugata , Wendner Ronald 
Published: February 2023

AbstractIn an endogenous growth model, we characterize the conditions under which positional preferences for consumption and wealth do not cause inefficiency and derive an optimal tax policy response in cases where these conditions are not satisfied. The concerns for relative consumption and relative wealth partly emanate from social comparisons with people in other countries. We distinguish between a (conventional) welfarist government and a non-welfarist government that does not attach any social value to relative concerns. We also compare the outcome of Nash-competition among local/national governments with the resource allocation implied by a global social optimum both under welfarism and non-welfarism.
Relation between laxative use and risk of major bleeding in patients with atrial fibrillation and heart failure
Authors: Yamamoto Jumpei , Yamamoto Masaya , Hara Hisao , Hiroi Yukio 
Published: February 2023

AbstractConstipation has been reported to increase the risk of cardiovascular mortality. Patients with atrial fibrillation (AF) and heart failure (HF) have more comorbidities and an increased bleeding risk. However, it remains unclear whether constipation is associated with an increased risk of incident bleeding complications in AF with HF. Here, we investigated the association between constipation requiring laxatives and major bleeding in AF and HF. We retrospectively analyzed the medical records of 370 consecutive patients hospitalized for AF and congestive HF. Constipation was defined as regularly taking laxatives or having at least two prescriptions for a ≥ 30-day supply of laxatives. Sixty patients experienced major bleeding events during a median follow-up of 318 days. The most common sites of bleeding were lower gastrointestinal (28%, 17/60), upper gastrointestinal (27%, 16/60), and intracranial (20%, 12/60). There were 33 (55%) patients with constipation in the bleeding group and 107 (35%) in the non-bleeding group (P = 0.004). Multivariate Cox regression analysis adjusted for HAS-BLED score, hemoglobin, and direct oral anticoagulant use showed that constipation (hazard ratio [HR] 1.85, 95% confidence interval [CI] 1.11–3.08; p = 0.019) was a significant risk factor for major bleeding. We found a significant association between constipation requiring laxatives and major bleeding in patients with AF and HF. These findings indicate the need for constipation prevention in these patients to avoid reliance on invasive defecation management, including laxatives.