bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liver cirrhosis: relationship between fibrosis-associated hepatic morphological changes and portal hemodynamics using four-dimensional flow magnetic resonance imaging
Authors: Higaki Atsushi , Kanki Akihiko , Yamamoto Akira , Ueda Yu , Moriya Kazunori , Sanai Hiroyasu , Sotozono Hidemitsu , Tamada Tsutomu 
Published: January 2023

Abstract
Purpose
The mechanisms underlying the morphological changes in liver cirrhosis remain unknown. This study aimed to clarify the relationship between fibrotic hepatic morphology and portal hemodynamic changes using four-dimensional flow magnetic resonance imaging (MRI).

Materials and methods
Overall, 100 patients with suspected liver disease who underwent 3-T MRI were evaluated in this retrospective study. Liver fibrosis was assessed using a combination of visual assessment of the hepatic morphology and quantitative measures, including the fibrosis-4 index and aspartate transaminase-to-platelet ratio. It was classified into three groups according to the severity of fibrosis as follows: A (normal), B (mild-to-moderate), and C (severe). Quantitative indices, including area (mm2), net flow (mL/s), and average velocity (cm/s), were measured in the right portal vein (RPV) and left portal vein (LPV), and were compared across the groups using the Kruskal–Wallis and Mann–Whitney U tests.

Results
Among the 100 patients (69.1 ± 12.1 years; 59 men), 45, 35, and 20 were categorized into groups A, B, and C, respectively. The RPV area significantly differed among the groups (from p < 0.001 to p = 0.001), showing a gradual decrease with fibrosis progression. Moreover, the net flow significantly differed between groups A and B and between groups A and C (p < 0.001 and p < 0.001, respectively), showing a decrease during the early stage of fibrosis. In the LPV, the net flow significantly differed among the groups (from p = 0.001 to p = 0.030), revealing a gradual increase with fibrosis progression.

Conclusion
The atrophy–hypertrophy complex, which is a characteristic imaging finding in advanced cirrhosis, was closely associated with decreased RPV flow in the early stage of fibrosis and a gradual increase in LPV flow across all stages of fibrosis progression.
Effect of Aluminizing on the Fatigue and High-Temperature Corrosion Resistance of Inconel 740 Nickel Alloy
Authors: Barwinska Izabela , Kopec Mateusz , Kukla Dominik , Łazińska Magdalena , Sitek Ryszard , Kowalewski Zbigniew L. 
Published: January 2023

AbstractThe fatigue response and high-temperature corrosion resistance of Inconel 740 nickel alloy in its as-received state, and the same material with aluminized surface layer, were investigated. The aluminized layer was applied by using the chemical vapor deposition process with the participation of AlCl3 vapors under a hydrogen protective atmosphere at a temperature of 1040°C for 8 h and internal pressure of 150 hPa. The microstructure of the aluminized layer was characterized through scanning electron microscopy and x-ray energy dispersive spectroscopy analysis. It was found that Inconel 740 with an aluminized surface exhibited an improved hardness and fatigue response of 100 MPa in the whole range of stress amplitudes from 350 MPa to 650 MPa. Additionally, the application of the aluminization process enhanced service life as well as the corrosion resistance of the alloy in question and effectively protected it against high-temperature corrosion.
MicroRNA-650 Regulates the Pathogenesis of Alzheimer’s Disease Through Targeting Cyclin-Dependent Kinase 5
Authors: Lin Li , Liu Xiaodong , Cheng Xuejun , Li Yujing , Gearing Marla , Levey Allan , Huang Xiaoli , Li Ying , Jin Peng , Li Xuekun 
Published: January 2023

Abstract
Alzheimer’s disease (AD) pathogenesis feature progressive neurodegeneration, amyloid-β plaque formation, and neurofibrillary tangles. Ample evidence has indicated the involvement of epigenetic pathways in AD pathogenesis. Here, we show that the expression of microRNA 650 (miR-650) is altered in brains from AD patients. Furthermore, we found that the processing of primary miR-650 to mature miR-650 is misregulated. Bioinformatic analysis predicted that miR-650 targets the expression of three AD-associated components: Apolipoprotein E (APOE), Presenilin 1 (PSEN1), and Cyclin-Dependent Kinase 5 (CDK5), and we have experimentally confirmed that miR-650 is able to significantly reduce the expression of APOE, PSEN1, and CDK5 in vitro. Importantly, the overexpression of miR-650 was further shown to significantly alter the CDK5 level and ameliorate AD pathologies in APP-PSEN1 transgenic mice. Overall, our results indicate that miR-650 influences AD pathogenesis through regulation of CDK5.
Second harmonic generation microscopy: a powerful tool for bio-imaging
Authors: Aghigh Arash , Bancelin Stéphane , Rivard Maxime , Pinsard Maxime , Ibrahim Heide , Légaré François 
Published: January 2023

Abstract
Second harmonic generation (SHG) microscopy is an important optical imaging technique in a variety of applications. This article describes the history and physical principles of SHG microscopy and its more advanced variants, as well as their strengths and weaknesses in biomedical applications. It also provides an overview of SHG and advanced SHG imaging in neuroscience and microtubule imaging and how these methods can aid in understanding microtubule formation, structuration, and involvement in neuronal function. Finally, we offer a perspective on the future of these methods and how technological advancements can help make SHG microscopy a more widely adopted imaging technique.
Cohesion and segregation in the value migration network: Evidence from network partitioning based on sector classification and clustering
Authors: Siudak Dariusz 
Published: January 2023

AbstractCluster structure detection of the network is a basic problem of complex network analysis. This study investigates the structure of the value migration network using data from 499 stocks listed in the S&P500 as of the end of 2021. An examination is carried out whether the process of value migration creates a cluster structure in the network of companies according to economic activity. Specifically, the cohesion and segregation of the extracted modules in the network division according to (i) sector classification, (ii) community division, and (iii) network clustering decomposition are assessed. The results of this study show that the sector classification of the value migration network has a non-cohesive structure, which means that the flow of value in the financial market occurs between companies from various industries. Moreover, the divisions of the value migration network based on community detection and clustering algorithm are characterized by intra-cluster similarity between the vertices and have a strong community structure. The structure of the network division into modules corresponding to the classification of economic sectors differs significantly from the partition based on the algorithms applied.
On symplectic Banach spaces
Authors: Castillo Jesús M. F. , Cuellar Wilson , González Manuel , Pino Raúl 
Published: January 2023

AbstractWe extend and generalize the result of Kalton and Swanson ($$Z_2$$

Z
2

is a symplectic Banach space with no Lagrangian subspace) by showing that all higher order Rochgberg spaces $${\mathfrak {R}}^{(n)}$$

R

(
n
)

are symplectic Banach spaces with no Lagrangian subspaces. The nontrivial symplectic structure on Rochberg spaces of even order is the one induced by the natural duality; while the nontrivial symplectic structure on Rochberg spaces of odd order requires perturbation with a complex structure. We will also study symplectic structures on general Banach spaces and, motivated by the unexpected appearance of complex structures, we introduce and study almost symplectic structures.
Editorial introduction: Biomedicine and life sciences as a challenge to human temporality
Authors: Rimon-Zarfaty Nitzan , Schweda Mark 
Published: January 2023

AbstractBringing together scholars from philosophy, bioethics, law, sociology, and anthropology, this topical collection explores how innovations in the field of biomedicine and the life sciences are challenging and transforming traditional understandings of human temporality and of the temporal duration, extension and structure of human life. The contributions aim to expand the theoretical debate by highlighting the significance of time and human temporality in different discourses and practical contexts, and developing concrete, empirically informed, and culturally sensitive perspectives. The collection is structured around three main foci: the beginning of life, the middle of life, and later life. This structure facilitates an in-depth examination of specific technological and biographical contexts and at the same time allows an overarching comparison of relevant similarities and differences between life phases and fields of application.
Are higher antidepressant plasma concentrations associated with fall risk in older antidepressant users?
Authors: Pronk A. C. , van Poelgeest E. P. , Seppala L. J. , Ploegmakers K. J. , Stricker B. H. , Swart K. M. A. , van Dijk S. C. , Oliai Araghi S. , de Groot L. C. P. G. M. , van Schoor N. M. , Mathôt R. A. A. , van der Velde N. 
Published: January 2023

AbstractPurposeAntidepressants are well-established fall-risk increasing drugs (FRIDs) and therefore falls should be considered an important adverse drug event (ADE) of antidepressants. However, not all antidepressant users experience fall incidents and factors associated with increased fall risk among antidepressant users are incompletely understood. Our objective was to explore whether antidepressant plasma concentrations are associated with falls in older antidepressant users.MethodsFor this study, we included antidepressant users of the multicenter B-PROOF study. Fall incidents were recorded prospectively using fall calendars. Antidepressant plasma concentrations were analyzed by Liquid chromatography-mass spectrometry (LC–MS) at baseline and at 2 years follow-up. The associations between the observed antidepressant concentration and fall risk were assessed using Cox proportional hazard and logistic regression models and adjusted for potential confounders.ResultsIn total 93 selective serotonin reuptake inhibitor (SSRI) and 41 antidepressant (TCA) users were identified. There was a significant association between baseline TCA plasma concentration and fall risk within users (HR 2.50, 95% CI 1.07–5.87, crude model). In the adjusted model, there were no significant associations between concentrations of SSRIs and fall risk.ConclusionThere might be an association between plasma concentrations of TCAs and the risk of falling in older users. However, these results needs to be interpreted with caution considering the small sample size and accompanying limitation of confinement to crude analyses. Therefore, these novel findings need to replicated in a larger cohort, preferably including adjustment for potential confounders and more frequent measures of plasma concentrations is needed.
Filter and sensor delay synchronization in incremental flight control laws
Authors: Steffensen Rasmus , Steinert Agnes , Mbikayi Zoe , Raab Stefan , Angelov Jorg , Holzapfel Florian 
Published: January 2023

AbstractThis paper introduces and investigates several methods of filtering and delay synchronization in incremental control law structures. It is shown that proper filter and delay synchronization is of great importance for both the performance and stability of the control laws. It is derived how to synthesize complementary filters in case of sensor dynamics, sensor delays and internal control law filtering such as roll-off filters and notch filters. The complementary filters are compared to common synchronization approaches previously applied in incremental control laws. It is shown that the proposed methods are beneficial for Multiple Input Multiple Output (MIMO) systems in case that different delays and filtering is present in the different measurement signals. In case of strongly coupled input effectiveness, the synchronization on the actuator feedback may become even unstable, where the complementary filter approach recovers the design closed-loop behavior. In addition, it is derived how to initialize the complementary filters for a transient-free engagement in non-steady-state conditions. The results are compared in simulation with a roll rate control law for a fixed wing aircraft.
The mediating role of exogenous shocks in green purchase intention: evidence from italian fashion industry in the Covid-19 era
Authors: Annunziata Eleonora , Pucci Tommaso , Cammeo Jacopo , Zanni Lorenzo , Frey Marco 
Published: January 2023

AbstractThis work investigates how the COVID-19 outbreak has affected consumers’ green purchasing intention in the fashion industry. It examines how this exogenous shock has influenced the relationship between consumer green purchasing intention and its three relevant antecedents (environmental knowledge (EK), environmental concern (EC), eco-friendly behaviour (EFB)). A survey of 1433 Italian consumers was carried out. The data were analysed through a structural equation modelling method to evaluate the direct and indirect mediating effects of the COVID-19 shock on the relationship between green purchasing intention and its antecedents (i.e., EK, EC and EFB) by considering traditional and online purchasing channels. The results of the model confirmed a positive relationship between green purchasing intention and its antecedents. The COVID-19 pandemic was also found to positively mediate the relationship between green purchase intention and two out of its three antecedents (i.e., EK and EC) in both traditional and online purchasing channels. This paper contributes to the literature on sustainable consumption by assessing magnitude of the relationship between green purchasing intention and its antecedents, and the mediating role exerted by a complex exogenous shock such as the COVID-19 outbreak.
Vertical industry and strategic trade policy
Authors: Fanti Luciano , Buccella Domenico 
Published: January 2023

AbstractThis paper investigates whether and how vertical industries have the characteristics to be targeted with the subsidy policy instrument. Under both price and quantity competition, the results of the established literature are reversed when exporters are in vertical relations. In particular, the conventional result that the emerging subsidising equilibrium is Pareto inefficient (the well-known prisoner's dilemma outcome) vanishes in the following cases: (1) under quantity competition, when products are sufficiently differentiated, and (2) under price competition, when products are neither too differentiated nor too substitutes. In such cases, the policy intervention leads to welfare improvement with respect to the free trade regime in both producing countries. Moreover, under price competition, export subsidization becomes the rule instead of taxation. Our results suggest that, depending on the degree of competition, vertical industries can be efficiently targeted through the subsidy policy.
Teaching, learning and assessment methods for sustainability education on the land–sea interface
Authors: Bryhn Andreas C. , Belgrano Andrea 
Published: January 2023

AbstractThe Land–Sea Interface (LSI) is where land and sea meet, not only in physical terms, but also with regards to a large variety of ecological and societal aspects. The United Nations has proclaimed the period 2021–2030 the Ocean Decade, which entails striving for a sustainable use of the ocean and teaching and learning about ocean related issues. Teaching and learning about the LSI are also tightly connected with several Sustainable Development Goals (Global Goals) such as Life Below Water, Zero Hunger and Sustainable Cities and Communities. Teaching and learning about sustainability lacks a uniform pedagogy, and it is probably wise to maintain that apparently adaptive diversity. In this globally relevant methods overview, we present a wide range of relatively new and/or successful and mostly largely learner-centered methods. We also discuss how effective and popular they are, and give examples on how most of these methods are already used in LSI sustainability teaching. There will probably not be any successful “one size fits all” model developing for LSI teaching and learning, and each module, course and programme will have to develop its own recipe for successful teaching and learning, possibly with support from one or several methods discussed in this paper.
Biochar nanoparticles-mediated transport of organic contaminants in porous media: dependency on contaminant properties and effects of biochar aging
Authors: Ma Pengkun , Qi Zhichong , Wu Xuan , Ji Rong , Chen Wei 
Published: January 2023

AbstractLand application of biochar has been recommended as an effective soil amendment measure. Nonetheless, the applied biochar can accumulate co-existing contaminants. Meanwhile, nanoparticles formed due to biochar disintegration may facilitate contaminant transport in vadose zone and groundwater, posing a potential risk to the subsurface environment. Here, we show that the presence of pinewood- and rice straw-derived biochar nanoparticles (BCNPs) at parts per million level (~ 20 mg/L) can result in significant mobilization of hydrophobic, nonpolar contaminants (naphthalene and pyrene) and positively charged polar contaminants (trimethoprim and ciprofloxacin) in saturated sandy soil, but slightly inhibits the transport of negatively charged or neutral hydrophilic compounds (sulfamethoxazole and bisphenol A). With supplemental adsorption and desorption experiments we show that the ability of BCNPs in mediating contaminant transport (either enhancing or inhibiting) relies primarily on the extent of irreversible binding of a contaminant to the BCNPs. Sulfide reduction and leaching of organic carbon, two relatively mild (in terms of modification of physicochemical properties, e.g., surface O/C ratio) but widely occurring aging processes, facilitate co-transport of pyrene and bisphenol A with the BCNPs. However, this is mainly the result of increased mobility of the BCNPs (i.e., the carrier), rather than enhanced interactions between the BCNPs and the contaminants being carried. The findings underline the significant effects of BCNPs on the fate and transport of environmental contaminants, and further highlight the important role of aging in affecting environmental behaviors and effects of biochar materials.
Graphical Abstract
Autophagy of naïve CD4+T cells in aging – the role of body adiposity and physical fitness
Authors: Padilha Camila S. , Kushkestani Mehdi , Baptista Liliana P. , Krüger Karsten , Lira Fábio Santos 
Published: January 2023

AbstractLife expectancy has increased exponentially in the last century accompanied by disability, poor quality of life, and all-cause mortality in older age due to the high prevalence of obesity and physical inactivity in older people. Biologically, the aging process reduces the cell’s metabolic and functional efficiency, and disrupts the cell’s anabolic and catabolic homeostasis, predisposing older people to many dysfunctional conditions such as cardiovascular disease, neurodegenerative disorders, cancer, and diabetes. In the immune system, aging also alters cells' metabolic and functional efficiency, a process known as ‘immunosenescence’, where cells become more broadly inflammatory and their functionality is altered. Notably, autophagy, the conserved and important cellular process that maintains the cell’s efficiency and functional homeostasis may protect the immune system from age-associated dysfunctional changes by regulating cell death in activated CD4+ T cells. This regulatory process increases the delivery of the dysfunctional cytoplasmic material to lysosomal degradation while increasing cytokine production, proliferation, and differentiation of CD4+ T cell-mediated immune responses. Poor proliferation and diminished responsiveness to cytokines appear to be ubiquitous features of aged T cells and may explain the delayed peak in T cell expansion and cytotoxic activity commonly observed in the ‘immunosenescence’ phenotype in the elderly. On the other hand, physical exercise stimulates the expression of crucial nutrient sensors and inhibits the mechanistic target of the rapamycin (mTOR) signaling cascade which increases autophagic activity in cells. Therefore, in this perspective review, we will first contextualize the overall view of the autophagy process and then, we will discuss how body adiposity and physical fitness may counteract autophagy in naïve CD4+ T cells in aging.
Latest Ordovician to earliest Silurian graptolites of northwest Peninsular Malaysia
Authors: Saparin Muhammad Aqqid , Ismail Mohd Suhaili 
Published: January 2023

AbstractGraptolites from the latest Ordovician to the earliest Silurian rocks of northwest Peninsular Malaysia are described and reviewed. The fossils were collected previously by C. R. Jones and presently by the authors inside the black mudstones from the basal section of Tanjung Dendang Formation in Pulau Langgun, Langkawi, which comprises assemblages from the Hirnantian Metabolograptus extraordinarius Biozone to the Rhuddanian Akidograptus ascensus–Parakidograptus acuminatus Biozone. The latest Ordovician strata also include a Hirnantia fauna bed between the Metabolograptus extraordinarius and Metabolograptus persculptus biozones, in which shelly fossils such as Mucronaspis sp. could be recovered. A revised graptolite biozonation is proposed for the latest Ordovician to the earliest Silurian succession of northwest Peninsular Malaysia. This interval is significant for understanding the extent of mass extinction events happening right at the end of the Ordovician period and subsequent faunal change in the region.
Religious Authority beyond Domination and Discipline: Epistemic Authority and Its Vernacular Uses in the Shi‘i Diaspora
Authors: Bhojani Ali-Reza , Clarke Morgan 
Published: January 2023

Abstract“Religious authority” remains a ubiquitous but controversial term of comparative analysis. In Islamic studies, authority is generally personified in the form of the ulama and most often viewed through Weber’s lens of charismatic, legal-rational, and traditional types of legitimate domination. Our particular interest, Twelver Shi‘i Islam, seems a paradigmatic case, where the relationship between “the Ayatollahs” and state power has dominated academic discussion since Khomeini. Through ethnography of a Shi‘i diaspora community in the UK, we argue for a radical shift in perspective: away from forms of clerical power and towards non-specialist uses of clerical authority as expert opinion. Far from such “epistemic” authority being opposed to ordinary agency, here they are inextricably linked. Inspirational work in the anthropology of Islam has understood ordinary Muslim experiences of authority in non-liberal ways, as (Foucauldian) ethical discipline and self-care. We maintain the need to transcend not only domination but discipline too, refocusing the comparison between (Shi‘i) Islamic legal and liberal thought, in the form of Raz’s classic “service conception” of authority. Both stress the rationality of following authoritative opinion and its role as reason and justification for individual action. Our ethnography of ordinary practice then shows the sheer diversity of ways that such epistemic authority can be taken up, including, but not limited to, projects of personal piety and adversarial community politics. In our context, as surely also in others, domination and discipline should thus be seen as potential uses of “religious” epistemic authority, rather than as its privileged form.