bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angina Severity and Symptom Improvement Are Associated With Diagnostic Acetylcholine Provocation Dose in Vasospastic Angina
Authors: Crooijmans C. , Jansen Tijn P. J. , Meeder Joan G. , Paradies Valeria , de Vos Annemiek M. J. , Woudstra Pier , Vossenberg Tessel N. E. , van de Hoef Tim P. , Vos Nicola S. , Olde Bijvank Els G. M. , van den Oord Stijn C. H. , Winkler Patty , Meuwissen Martijn , Widdershoven Jos W. M. G. , Arkenbout E. Karin , Stoel Martin G. , Appelman Yolande , Beijk Marcel A. M. , Cetinyurek‐Yavuz Aysun , den Ruijter Hester M. , Elias‐Smale Suzette E. , van Royen Niels , Dimitriu‐Leen Aukelien C. , Damman Peter ,   for NL‐CFT
Published: January 2025

Background
A coronary function test (CFT) is the recommended diagnostic test to identify coronary vasomotor dysfunction as a cause of symptoms in patients with angina and nonobstructive coronary arteries (ANOCA). Acetylcholine is the commonly used pharmacological agent for spasm provocation. We aimed to investigate an association between severity of symptoms and provocative acetylcholine dose.

Methods and Results

We included ANOCA patients undergoing clinically indicated CFT from the Netherlands Registry of Invasive Coronary Vasomotor Function Testing: NL‐CFT. Patients with epicardial spasm (n=251) were divided according to acetylcholine spasm triggering dose: low (2–20 mcg, EpiLOW), middle (100 mcg, EpiMIDDLE) or high (200 mcg, EpiHIGH). Patients with microvascular spasm (n=157) were analyzed irrespective of triggering dose. The patient groups were compared to each other and to a control group with negative CFT results (n=101). We assessed mean Seattle Angina Questionnaire angina frequency and summary scores at baseline and follow‐up and the proportion of patients improving or deteriorating. An inverse relationship between provocation dosage and angina frequency at baseline was found in epicardial spasm: the lower the triggering dose, the more frequently patients experienced angina (EpiLOW 48±20, EpiMIDDLE 53±21, EpiHIGH 57±19, microvascular spasm 61±21, controls 64±21, overall
P
=0.003). A trend was seen toward most patients improving in the high triggering dose group, and most patients deteriorating in the low triggering dose group.

Conclusions
A significant dose‐dependent relationship between spasm provocation and anginal complaints exists. Acetylcholine provocation dose could be incorporated as a risk stratification factor or surrogate outcome in future clinical trials.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT06083155.
Language and Attention Networks Have Distinct Roles in Language Improvement Following an Intensive Comprehensive Aphasia Program
Authors: Houldin Evan , Babbitt Edna M. , Hurwitz Rosalind , Baliki Marwan N. , Cherney Leora R. 
Published: January 2025

BACKGROUND:
Attention is known to play an important role in language, and attentional deficits have been associated with language impairments in people with aphasia (PWA). A prior study by our laboratory indicated that behavioral measures for PWA participating in an intensive comprehensive aphasia program (ICAP) clustered into 1 language and 1 attention-related factor, with each factor correlated with independent resting state functional connectivity (rsFC) networks. The present study includes additional attention measures and participants to better assess the relationship between attention, language, and rsFC.

METHODS:
PWA participated in 120 hours of ICAP therapy over 4 weeks, between April 2018 and August 2022. Participants were evaluated with the Western Aphasia Battery and Conners’ Continuous Performance Test, pre- and post-ICAP. rsFC data were collected during functional magnetic resonance imaging scans pre- and post-ICAP. Principal component analysis identified behavioral score associations pre- and post-ICAP. FC matrices and graph measures were evaluated for both PWA and healthy controls.

RESULTS:

Twenty-three PWA participated (19 included in the final analysis). Data for 179 age and sex-matched healthy controls were taken from a public data set. The principal component analysis indicated 1 language and 2 attention-related principal components (PCs). The attention PCs were labeled Attention Accuracy and Attention Rate, in accordance with their best-associated behavioral measures. Importantly, each PC was associated with distinct networks, including higher-order networks, so-called because of their involvement in higher-order cognition. Notably, the language PC was significantly correlated with the ventral attention-memory–retrieval network rsFC (
r
=0.67,
P
=0.003) and the default mode–frontoparietal network rsFC (
r
=−0.56,
P
=0.019). Attention Accuracy was significantly correlated with cingulo-opercular–subcortical network rsFC (
r
=0.60,
P
=0.011). Attention Rate was significantly negatively correlated with visual-somatomotor network rsFC (
r
=−0.74,
P
=0.0007).

CONCLUSIONS:
This study supports the notion that language improvements for PWAs participating in an ICAP are associated with distinct network changes. Importantly, these networks are not restricted to language networks but also include attention, and task-control networks.
Immersive Scientific Communication: A Multidimensional Theoretical Model for Approaching Extended Reality as a Medium
Authors: Rubio-Tamayo Jose Luis , Gertrudix Manuel , Wuebben Daniel 
Published: January 2025

Abstract
Extended reality (XR) promises to dramatically change the framework of scientific communication. XR offers new possibilities for creating engaging scientific content, presenting complex information, and designing immersive experiences. Scientists and communicators need to better understand interactive and immersive narratives to harness these potentials of XR. This essay proposes a multidimensional theoretical model for immersive scientific communication that evaluates the interface models of XR, analyses its levels of reality and interaction, and identifies the dominant characteristics of the narrative. This model promotes the critical and reflective application of XR to science communication, especially Citizen Science projects.
Charting the Transformative Journey of Augmented Reality in Graphic Design Education: A Comprehensive Overview of the Period 2016–2022
Authors: Wang Jiawei , Mokmin Nur Azlina Mohamed , Ji Shaorong 
Published: January 2025

Abstract
Continuous innovation in instructional technology has propelled augmented reality (AR) to the forefront of educational tools that universities and research institutions promote globally. Graphic design, an art discipline requiring high-dimensional interaction, benefits from AR's ability to enhance interactivity in virtual and physical teaching environments. This study explores trends in AR development within graphic design education, focusing on college students. A systematic literature review from 2016 to 2022 investigates AR applications in art teaching and their impact on students. Findings indicate limited use of AR in graphic design education, predominantly focusing on marker-based AR, highlighting a research gap in exploring other AR types. This study contributes to the field by identifying the need for diverse AR applications and providing insights into their potential to enhance student engagement, creativity, and learning outcomes in graphic design.
Tyconius the African: Reassessing the Theory of His Greek Origins
Authors: Caminiti Joshua 
Published: January 2025

Abstract
Recent literature on Tyconius has assembled something of a consensus towards Steinhauser’s suggestion that Tyconius was an ethnic Greek. This theory was originally proposed to mollify the central riddle of Tyconian studies which has vexed his readers since Augustine: how could he have remained a Donatist? By proposing him as an ethnic outsider to an African controversy, his puzzling ecclesiastical affiliation might thereby be explained. This article seeks to challenge this account in establishing two points. The first is to argue the sincerity of Tyconius as a Donatist, situating him within the diversity of “Donatisms”, and examine the principles of his Donatist conviction. Secondly, showing his intense interest in Africa from a theological and ecclesiological perspective, this paper concludes we have no reason to suppose that he was anything other than an African among Africans, and the theory of his Greek origins must be registered with some caution or dismissed.
Enhancing performance of black soldier fly (Hermetia illucens) larvae by feeding on king oyster mushroom as a source of β-glucan
Authors: Mansoor S. , Tirtawijaya G. , Bashir K.M.I. , Lee J.-H. , An H.R. , Sohn J.-H. , Lee H.-J. , Choi J.-S. 
Published: January 2025

Abstract
The study investigated the effects of dietary supplementation with king oyster mushroom (KOM) on the growth performance, nutritional properties, and β-glucan content in black soldier fly (Hermetia illucens) larvae (BSFL). Although BSFL are an excellent source of high-quality protein, they naturally have low β-glucan content, which is renowned for its potent antioxidant and anti-inflammatory properties. Using chicken feed as a basal medium, fortified with varying concentrations of KOM (0-50%), the growth performance, nutritional value, β-glucan content, and bioactive properties of the larvae were assessed through in vitro assays. By the seventh day, BSFL reared on 10% KOM-supplemented feed showed a significant increase in body weight to 51.64 ± 0.9 mg, compared to 36.74 ± 1.22 mg for those on non-supplemented feed, representing a 13-fold increase from the initial weight of 4 mg on day 0. Additionally, larvae on 10% KOM showed a 9.12% increase in protein content (33.65 ± 0.009%) and a 14.56% increase in lipid content (33.053 ± 0.012%) compared to those on non-supplemented feed. KOM supplementation significantly () enhanced the β-glucan content, with a remarkable 36-fold increase at 50% KOM. Moreover, hot water extracts from larvae fed on 10% KOM-fortified feed exhibited enhanced antioxidant activities, such as DPPH and ABTS radical scavenging, and increased superoxide dismutase (SOD) activity. Anti-inflammatory activities were also indicated by reduced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Overall, the findings suggest that KOM supplementation significantly boosts β-glucan content, growth performance, nutritional value, and bioactive properties in BSFL, indicating their potential as a functional food and feed source offering enhanced nutritional and health benefits.
Dietitian perspective and experience: Implementation of telenutrition in Indonesia and the challenge of performing the nutrition-focused physical examination (NFPE)
Authors: Aulia Bianda , Mayasari Meike , Notarianti Rizna , Pranoto Yosephin Anandati 
Published: January 2025

Background Nutrition assessment is the first step of the nutrition care process (NCP), which includes investigating physical status and malnutrition signs. With the widespread digitalization of healthcare in Indonesia, including telehealth in dietetic practice (telenutrition), evidence is required to address the barriers and improve the current practice of conducting remote physical assessments. Aim This study aimed to explore the adaptation of nutrition-focused physical examination (NFPE) using telenutrition in Indonesia. Methods This qualitative study recruited Indonesian registered dietitians (RD) with experience in performing NCP using video conferences, phone calls, or other remote/online platforms. The search for participants was conducted until the information was considered sufficient. Data were collected using semistructured in-depth interviews. Thematic analysis was used to analyze the data. Results Eleven RDs were interviewed via video conference. Three themes emerged from the analysis: (1) feasibility and practicality, (2) barriers, and (3) adaptations and pre-requisites of remote physical assessment. Remote physical assessment was considered not practical by the majority. Barriers were categorized into technological challenges, lack of NFPE training and practice, and challenges in involving patients. Pre-appointment preparations, guiding the patients through video calls, or asking patients to send images of their bodies are adaptations needed for remote physical assessment. Conclusion Challenges in remote physical assessment could be minimized by establishing protocols to deliver standardized care and ensure session efficiency. Additionally, strengthening the implementation and training of NFPE for dietitians in Indonesia is of paramount importance.
Limitations and Future Directions in Pharmacological Treatment for Amphetamine-Type Stimulant Use Disorder
Authors: Bahji Anees 
Published: January 2025

Plain Language Summary Why Current Treatments for Stimulant Addiction Often Fall Short: Insights and Future Directions Stimulant addiction, such as addiction to drugs like amphetamines, is a growing public health concern, but there are very few effective medications to treat it. A recent study reviewed a drug called modafinil and found it didn't help reduce drug use, cravings, or improve treatment outcomes. This article discusses why treatments that work for other addictions, like opioids, are less effective for stimulants. It also highlights the challenges researchers face, such as differences in study methods and overlooking common issues like mental health problems or using multiple substances. The focus on complete abstinence as a treatment goal is another issue. Harm reduction, which involves reducing drug use and improving health and social well-being, could be more realistic and beneficial for many people. Finally, while therapy remains the most effective treatment, it's not always accessible. This article calls for new, innovative approaches that prioritize harm reduction, safety, and long-term recovery.
Effect of bioactive glass on the properties of glass/polymer composite scaffold fabricated by solvent casting/particulate leaching technique
Authors: Suhaimin Intan Syazana , Abu Kassim Syamimi , Ahmad Zubir Syazana , Abdullah Tuti Katrina 
Published: January 2025

This study fabricated Bioglass® reinforced polyurethane (PU) scaffolds by solvent casting/particulate leaching technique to investigate the effect of Bioglass® percentage on the properties of the PU scaffolds. Bioglass® percentage was varied for 0 wt %, 10 wt %, 20 wt %, 30 wt %, 40 wt % and 50 wt % in the PU matrix. The composite scaffolds were characterized using a field emission scanning electron microscope (FESEM) equipped with energy dispersive X-ray (EDX) to observe the morphology and compositions of the scaffolds, and Fourier transform infrared spectroscopy (FTIR) to analyze functional group interactions. Their properties were thoroughly assessed through porosity testing, compression testing and in-vitro bioactivity evaluation. Results demonstrated that increased Bioglass® percentage improved the compressive strength of the PU-BG scaffolds from 0.5 MPa to 1.5 MPa. The in-vitro test revealed that the addition of Bioglass® induced and accelerated the bioactivity of PU-BG scaffolds. When 50% of Bioglass® was added, an apatite layer was formed on the composite scaffolds after 14 days of incubation. The optimal Bioglass® content for improving both mechanical properties and bioactivity of PU scaffolds was found to be 50 wt %. These findings suggest that PU-BG composite scaffolds have potential applications in bone tissue engineering and may provide insights into designing bioactive scaffold materials for enhanced osteointegration.
DABiG: Breath pattern classification using the hybrid deep learning with optimal feature selection
Authors: Kaleeswari P , Ramalakshmi R , Arun Prasath T , Muthukumar A , Kottaimalai R , Thanga Raj M 
Published: January 2025

Background A person's breathing pattern can be a reflection of their emotional and physical well-being because it shows the frequency, intensity, and rhythm of their breathing. Objective This research article presents a comprehensive approach to breathe pattern classification utilizing gyroscope and accelerometer readings obtained from individuals using two distinct sensors. The study encompasses the acquisition of six diverse breathing patterns, with a focus on data pre-processing through Min-Max normalization. Methods To select essential features from the normalized data, an innovative optimization algorithm, Adaptive Chimp Optimization (AdCO), is introduced. AdCO integrates an adaptive weighting strategy into the conventional Chimp optimization algorithm, enhancing convergence rates and enabling global optimal feature selection. Furthermore, the article introduces the application of the selected features in breath pattern classification using a hybrid deep learning mechanism, DABiG. DABiG leverages the Bidirectional Gated Recurrent Unit (BiGRU), a neural network architecture capable of processing sequential data bi-directionally. Results Spatial and temporal attention mechanisms are incorporated into DABiG to enhance its ability to focus on relevant spatial regions and time steps within the breath pattern data. Conclusion Spatial attention assigns weights to spatial regions, while temporal attention assigns weights to time steps, improving feature extraction and classification accuracy.
Cleft-Related Revision Procedures: Surgeon Perspectives on Shared Decision-Making and a Decision Aid Prototype
Authors: Makar Katelyn G. , Tran Khoa D. , Brown Whitney , Vercler Christian J. 
Published: January 2025

Objective Decision-making for elective cleft lip and nose revisions varies widely, from patient-led decisions to more paternalistic approaches. As these procedures incur additional scarring that may impact future interventions, patients should be equipped to participate in these surgical decisions. We thus developed a decision aid based on international standards, and to ensure methodologic rigor, we sought feedback from other surgeons regarding shared decision-making and potential barriers to adopting the decision aid. Design The decision aid was developed based on qualitative patient data, expert opinion, and International Patient Decision Aid Standards (IPDAS). It was first piloted using a “think aloud” approach and subsequently revised. In the present study, this version was presented to a diverse focus group of surgeons. The conversation was audio-recorded and transcribed. The transcription was coded independently by 2 authors, and codes were categorized for theme development. Setting American Cleft Palate-Craniofacial Association meeting, April 2024. Participants Focus group of 8 board-certified craniofacial surgeons. Main Outcome Measures Surgeon feedback regarding appeal, usefulness, and generalizability of the decision aid. Result(s) Eight surgeons participated. Mean age was 43 years (SD 5.7), and mean number of years in practice was 9.3 (SD 6.0). Four were female, and 4 were male. Three themes emerged: (1) Appeal to the consumer, (2) Acknowledge the parents, and (3) Consider logistics of decision aid delivery. Conclusions Based on surgeon feedback, the decision aid will be web-based, explicitly recognize the importance of parents, and maximize the likelihood that patients viewing the decision aid are surgical candidates.
Fishhook Injuries and Antibiotic Prescribing Patterns: A Retrospective Analysis
Authors: Lazzara Alan A. , Sinkoff Jacob S. , Thompson Robert , Zahdan Khader , Baptiste Jonathan 
Published: January 2025

Introduction Fishhook injuries are a common occurrence among anglers. There are no guidelines for prophylactic antibiotic use after fishhook removal. This study analyzed the management of embedded fishhooks, prophylactic antibiotic use, and complication rate at a Michigan county emergency department to observe whether antibiotic use changes patient outcome. Commentary on a freshwater pathogen ( Aeromonas hydrophila) is also included. Methods Cases were obtained through a retrospective chart review of patients seen for fishhook injury between 2016 and 2022. We analyzed age, sex, relevant medical history, type of fishhook, site preparation, removal technique, antibiotic use, return visit within 30 days, and complications. Results Fifty-one patients with fishhooks injuries were identified. Mean age was 48±17 y. Forty-three patients were male (84%), and 8 were female (16%). Hook site varied, with most occurring in the finger/thumb (78.4%) and scalp (5.9%). One case involved the ear cartilage. The most common removal technique was the advance and cut method (52.9%). Four patients had an immunocompromising condition (eg, diabetes). Oral antibiotics were prescribed to 26 patients (51%) on discharge. Prophylactic antibiotic choice varied—cephalexin predominated (61.5%). There were no wound infections or complications in cases where the fishhook was removed during the emergency department encounter (50 of 51). One case involved a delayed presentation, abscess formation, and outpatient hand surgery referral. Conclusions In this small observational study, antibiotic prophylaxis for freshwater-associated fishhook injury did not change outcome regardless of fishhook location or presence of an immunocompromising condition. Further controlled studies are needed to determine the validity of these findings.
Determining the cutoff for thoracic trauma severity score for predicting the outcome following blunt thoracic trauma in an Indian population presenting to a level 1 trauma centre
Authors: Gupta Shubham K , Mishra Shashi P , Mishra Manjaree , Kumar Manish , Digumarthi Asha R , Hoda Inzamam ul , Choudhary Kingshuk , Gupta Sanjeev K 
Published: January 2025

Introduction In 2000, Pape and colleagues designed the Thorax Trauma Severity Score (TTSS) that integrated the anatomical and physiological parameters to predict the outcome following trauma to chest. Given the wide variability in the cut-off level for predicting outcome, we intended to analyze the cut-off and study the sensitivity and specificity of TTSS in our population in predicting the mortality. We also aimed to quantify the utility of TTSS at presentation in predicting the need for ICU care, and need for mechanical ventilation. Methodology A prospective cohort study was conducted on 300 blunt chest trauma patients presenting to Emergency Department of our level 1 Trauma Centre. Patients aged 18 years or above with blunt trauma chest with GCS > 13 at presentation were included. Data analysis was performed using IBM SPSS. The receiver operator curve (ROC) was used to evaluate the statistical significance of sensitivity and specificity and to choose suitable cut-off points to make a decision. Results Out of 300 patients, 230 were male (76.7%) and aged 38 ± 14.5 years. Road Traffic Accident was the commonest mode of injury (71.6%). Out of 239 patients who were admitted, 137 patients needed hospitalization for less than 7 days (good prognosis), 44 patients had fair prognosis, 27 needed admission to ICU and ventilator support and therefore had poor prognosis while 31 patients had fatal outcome. A cutoff of TTSS 11 or more had 96% sensitivity & 90% specificity for predicting poor outcome (p < 0.001; AUC = 0.921) and 87.4% sensitivity & 86.5% specificity for predicting fatal outcome (p < 0.001; AUC = 0.933). Conclusion A TTSS score of 11 and above was associated with poor (ICU admission and need for mechanical ventilation) and fatal outcome. A higher score is associated with higher morbidity & mortality [Level of evidence: Level 2].