bluuebunny/crossref_metadata_2025_split huggingface dataset:
Going from attitude to action: Analyzing how the orientations of sustainable food businesses influence their business strategies
Authors: Jusuf Katherine , Nuttavuthisit Krittinee 
Published: January 2023

AbstractFollowing an increasing interest in sustainable food systems, businesses have begun to look for ways to incorporate sustainability practices into their business models and strategies. However, the ability to follow through with their ambitions is obstructed by the attitude–behavior gap, a phenomenon that refers to the discrepancy between a decision‐maker's attitudes and beliefs and their resulting actions. This research studies the attitudes (including motives and intentions) of food‐related businesses in Thailand and their subsequent business decisions by conducting semi‐structured interviews with companies of varying sizes and types. The aim is to analyze possible gaps between attitudes and behaviors along the value chain management and explore relevant business practices. This study categorizes firms into profit, performance, and partnership orientations towards sustainability and concludes that different orientations result in differing degrees of attitude–behavior gap and divergent business strategies. Furthermore, business strategies in various markets are proposed to transition between sustainability orientations.
Genetic alterations of GI‐NECs involving three main signaling pathways
Authors: Dai Qiong , Zhang Jinping , Long Weili , Haybaeck Johannes , Yang Zhihui 
Published: January 2023

AbstractBackgroundGastrointestinal (GI)‐neuroendocrine neoplasms (NENs) are subclassified in neuroendocrine tumors (NETs), neuroendocrine carcinomas (NECs), and mixed neuroendocrine–non‐neuroendocrine neoplasms (MiNENs). The genetic characteristics of GI‐NEN has been a hot issue in recent years, but more studies are needed to provide further details. This study aims to provide additional data about genomic characteristics of GI‐NENs and the genetic differences between NETs and NECs.Patients and MethodsThirteen samples were selected for next‐generation sequencing (NGS) analysis with a 425‐gene panel. Microsatellite instability (MSI) and tumor mutational burden (TMB) were calculated as well as immunohistochemistry (IHC) was used to test for protein expression.ResultsGenetic alterations were very common in NECs, but rare in NETs. The average TMB of NETs and NECs was 2.3 and 6.9, respectively. The TMB of NECs was significantly higher compared to NETs. The TP53 mutation rate was significantly higher in NECs than in NETs (100% vs. 20%), other mutations involved MTOR (n = 2, 15.4%), DDR2 (n = 3, 23.1%), ERBB4 (n = 1, 7.7%), BRCA1 (n = 1, 7.7%), BRCA2 (n = 1, 7.7%), ATM (n = 1, 7.7%), and SMAD4 (n = 1, 7.7%). Deep loss of SMAD4 (1/3, 33.3%), SDHB (1/3, 33.3%), RB1 (1/3, 33.3%), and BRCA2 (1/3, 33.3%), high‐level amplification of CRKL (1/3, 33.3%), CCNE1(1/3, 33.3%), and MCL1(1/3, 33.3%) were found in NECs. The integrated analysis found these genetic alterations frequently involve DNA repair and cell cycle, PI3K/AKT/mTOR and TGF‐β/SMAD4 signaling pathways.ConclusionGenetic alterations were very common in NECs and rare in NETs, and frequently involved three main signaling pathways. NEC patients harboring these genetic alterations may benefit from targeted therapy and PD‐1/PD‐L1 immunotherapy.
Stairway to Stereoisomers: Engineering Short‐ and Medium‐Chain Ketoreductases To Produce Chiral Alcohols
Authors: Shanbhag Anirudh P. 
Published: January 2023

AbstractThe short‐ and medium‐chain dehydrogenase/reductase superfamilies are responsible for most chiral alcohol production in laboratories and industries. In nature, they participate in diverse roles such as detoxification, housekeeping, secondary metabolite production, and catalysis of several chemicals with commercial and environmental significance. As a result, they are used in industries to create biopolymers, active pharmaceutical intermediates (APIs), and are also used as components of modular enzymes like polyketide synthases for fabricating bioactive molecules. Consequently, random, semi‐rational and rational engineering have helped transform these enzymes into product‐oriented efficient catalysts. The rise of newer synthetic chemicals and their enantiopure counterparts has proved challenging, and engineering them has been the subject of numerous studies. However, they are frequently limited to the synthesis of a single chiral alcohol. The study attempts to defragment and describe hotspots of engineering short‐ and medium‐chain dehydrogenases/reductases for the production of chiral synthons.
Involvement of HIF1 stabilization and VEGF signaling modulated by Grx‐1 in murine model of bronchopulmonary dysplasia
Authors: Han Wenli , Zhang Fengmei , Mo Dandan , Zhang Xiao , Chen Bailin , Ding Xionghui , Guo Hongjie , Li Fang , Guo Chunbao 
Published: January 2023

AbstractHypoxia inducible factor (HIF)−1α could be stabilized by Grx1 deletion, which is implicated critical in the pathogenesis of bronchopulmonary dysplasia (BPD). Until now, the stabilization of HIF‐1α by glutathionylation to regulate the pulmonary microcirculation in BPD is not well addressed. In this study, we investigated whether the HIF‐1α stabilization modulated by Grx1 ablation could ameliorate the pathological changes in the mouse model of BPD, including angiogenesis and alveolar formation. We found that depletion of Grx1 increased levels of GSH‐protein adducts, which was associated with the improvement in the numbers of alveoli, the capillary density in the pulmonary microcirculation and the survival rate in the littermates with hyperoxic exposure. Grx1 ablation could promote HIF‐1α glutathionylation by increasing GSH adducts to stabilize HIF‐1α and to induce VEGF‐A production in the lung tissue. The above phenotype of capillary density and VEGF‐A production was removed by the pharmacological administration of YC‐1, the HIF‐1α inhibitor, suggesting the HIF‐1α dependent manner for pulmonary microcirculatory perfusion. These data indicate that HIF‐1α stabilization plays an critical role in modification pulmonary microcirculatory perfusion, which is associated with the pathological damage under hyperoxic conditions, suggesting that targeting with HIF‐1α stabilization should be a potential clinical and therapeutic strategy for BPD treatment.
Development and application of naturally derived, cost‐effective CQDs with cancer targeting potential
Authors: El‐borlsy Hanaa , Hanafy Nemany A. N. , El‐Kemary Maged A. 
Published: January 2023

AbstractCarbon quantum dots (CQDs) derived from natural sources have obtained potential interest in biomedical imaging and therapy because of their excellent biocompatibility properties, which include water solubility, simple synthesis and low cytotoxicity. Here the cytotoxicity of ethylene‐diamine doped carbon quantum dots (N‐CQDs) delivered to breast cancer MCF‐7 cells was investigated. Folic acid was used to raise folate recognition and increase FA‐NCQD accumulation in the cells, then apoptosis was assayed using nuclear fragmentation, acridine orange labeling, fluorescence imaging, flow cytometry, and caspase 3 expression. The data show that functionalization of these CQDs, derived from a natural source, have potential application in eliminating cancer cells, as shown here for the invasive breast cancer cells, MCF‐7. This nano‐delivery system provides a novel target therapy possibility therapeutic approach for cancer cells.
Effect of randomized prophylactic nitroglycerin on radial artery spasm during transradial catheterization: An analysis based on operator experience
Authors: da Silva Roberto L. , Dangas George D. , de Andrade Pedro B , Joaquim Rodrigo M. , da Silva Thais R. W. , Fattah Tammuz , Pereira Vanderlei C. , Zanella Ricardo A. , Sousa Amanda G. M. , Feres Fausto , Costa José R. 
Published: January 2023

AbstractOne limitation to transradial access (TRA) is the occurrence of spasms (RAS), for which the use of prophylactic medications is recommended. Improvement in TRA material combined with the increase in operators' expertise, might mitigate this benefit. We assess the effect of preventive nitroglycerin on RAS during TRA, evaluating the role of the operator's experience. Patients received 500 μg nitroglycerin or placebo. The operator's expertise was classified as: inexperienced (I), intermediate (M), and experienced (E). 2040 patients were included. Prophylactic use of nitroglycerin did not reduce RAS (10.8% vs. 13.4% (placebo), p = 0.07). RAS incidence was 14.5% in I, 12.5% in M, and 9.7% in E (p = 0.01). In group I, nitroglycerin reduced RAS (17.4% vs. 11.1%, p = 0.04), which was not observed in other groups. Overall, nitroglycerin does not prevent RAS, which is more common among inexperienced operators. More experienced operators could abolish preventive nitroglycerin use.
Conjugating Coumarin with Tetraphenylethylene to Achieve Dual‐State Emission for Reversible Mechanofluorochromism and Live Cell Imaging
Authors: Huang Ze , Ding Aixiang , Yang Jiaxiang , Wang Chengyuan , Tang Fang 
Published: January 2023

AbstractDual‐state emission luminogens (DSEgens) are receiving research interest in the construction of multifunctional materials due to their inherent advantage of high emission efficiency in both the molecularly dispersed solution state and the solid state. However, it remains challenging in synthesizing DSEgens via a delicate manipulation of the molecular structures. This work presents an example of bright DSEgen synthesis by tuning the molecular electronic structures and conformations. Three coumarin‐tetraphenylethylene (TPE) molecules with a donor‐acceptor electronic structure and highly twisting conformations have been synthesized. While compound resulting from direct conjugation of coumarin with a TPE unit shows aggregation‐induced emission, compound with an N,N‐diaminoethyl modification on the 7‐position of coumarin and compound with a further phenyl linker between coumarin and TPE units feature strong dual‐state emission. Benefiting from their strong solid emission and twisting conformations, these fluorophores display reversible mechanofluorochromism. Finally, applications for rewritable information storage in the solid state and live‐cell imaging in the solution state were demonstrated.
{V6} Ring Sandwiched Polyoxoniobate as Molecular Electrocatalyst for Oxidant‐Free Synthesis of Sulfoxides
Authors: Zhen Ni , Dong Jing , Lin Zhengguo , Li Zhen , Liu Chengpeng , Li Xiaoxia , Geng Weijie , Chi Yingnan , Hu Changwen 
Published: January 2023

AbstractElectrocatalytic oxidation of organic molecules to value‐added chemicals has attracted recent attention. Although a series of transition metal based electrocatalytic materials have been developed, the lack of precise structure information generates great challenges in understanding the catalytic mechanism at a molecular level. Herein, we present the synthesis and characterization of a molecular electrocatalyst, Na2K6H14[(VO)6(α‐TeNb9O33)2] ⋅ 31H2O ⋅ 2.5 C2H8N2 (abbreviated as V6(TeNb9)2), where a reduced {V6} ring is sandwiched by two trivacant Keggin‐type {α‐TeNb9O33}. V6(TeNb9)2 as heterogeneous electrocatalyst can selectively convert 95 % of thioanisole to sulfoxide with the Faraday efficiency up to 98 %. Notably, the important role of the embedded {V6} ring in the electrocatalytic oxidation was illustrated by comparing with {Nb6} ring sandwiched catalyst, Na5K7H4[(NbO)6(α‐TeNb9O33)2] ⋅ 17H2O (abbreviated as Nb6(TeNb9)2). Mechanism studies reveal that during the electrocatalytic oxidation process water is the only oxygen source and a key intermediate PhCH3S+⋅ is involved.
Depression and anxiety in patients with uveal melanoma undergoing curative proton treatment—A prospective study
Authors: Rabsahl Christopher , Boehmer Dirk , Boeker Alexander , Gauger Ulrich , Goerling Ute , Gollrad Johannes 
Published: January 2023

AbstractObjectiveWe prospectively addressed whether patient characteristics, oncological outcomes, or metastatic risk impacted depression and anxiety in patients undergoing curative proton treatment for uveal melanoma (UM).MethodsWe assessed patient‐reported outcomes regarding anxiety (GAD‐7) before and 2 years after proton therapy and depression (PHQ‐9) before, 1, and 2 years after proton therapy. We performed descriptive statistics and used linear mixed effect modeling to analyze how the oncological outcome and baseline characteristics impacted anxiety and depression scores.ResultsOf 130 (65 female) patients included, six developed metastatic disease and three died during the 2‐year follow‐up. The mean anxiety declined from 5.86 (SE = 0.56) at baseline to 3.74 (SE = 0.46) at 2 years (β = 2.11; SE = 0.6; p < .001). Depressive symptoms decreased moderately from 4.36 (SE = 0.37) at baseline to 3.67 (SE = 0.38) 2 years later. Patients with unfavorable metastatic risk or disease progression had elevated anxiety and depression scores. Although female patients reported overall higher anxiety scores, both sexes recovered substantially and to a similar extent during the 2‐year follow‐up (β = 2.35; SE 0.87; p = .007 vs. β = 1.88; SE = 0.60; p = .002). A trend for prolonged depressive symptoms was observed in patients living alone compared to patients living with family members 1 year after the treatment (M = 5.04 [SE = 0.85] vs. M = 3.73 [SE = 0.31], β = 1.32; SE = 0.92; p = .152). Patients with high baseline anxiety levels showed initially more severe depressive symptoms, which improved significantly during follow‐up (β = 1.65; SE = 0.68; p = .017).ConclusionMost patients undergoing proton therapy for UM experienced mild, transient depressive symptoms and anxiety. Patients with high pre‐treatment anxiety, unfavorable prognoses, and patients living alone may be more vulnerable to prolonged depressive symptoms. To these patients a more tailored support could be offered at an early stage of the disease.
Exploring therapist characteristics as potential moderators of the effects of client feedback on treatment outcome
Authors: Janse Pauline D. , Veerkamp Carola , de Jong Kim , van Dijk Maarten K. , Hutschemaekers Giel J. M. , Verbraak Marc J. P. M. 
Published: January 2023

AbstractAlthough studies have shown that client feedback can improve treatment outcome, little is known about which factors might possibly moderate the effects of such feedback. The present study investigated potential therapist variables that might influence whether frequent client feedback is effective, including the Big Five personality traits, internal/external feedback propensity and self‐efficacy. Data from two previous studies, a quasi‐experimental study and a randomized controlled trial, were combined. The sample consisted of 38 therapists and 843 clients (55.4% females, mean age = 42.05 years, SD = 11.75) from an outpatient mental health institution. The control condition consisted of cognitive‐behavioural therapies combined with low frequency monitoring of clients' symptoms. In the experimental condition, high‐intensity (i.e., frequent) client feedback as an add‐on to treatment as usual was provided. Outcomes were measured as adjusted post‐treatment symptom severity on the Symptom Checklist‐90 and drop out from treatment. The final model of the multilevel analyses showed that therapists with higher levels of self‐efficacy had poorer treatment outcomes, but when high‐intensity client feedback was provided, their effectiveness improved. Furthermore, higher self‐efficacy was associated with a higher estimation of therapists' own effectiveness, but therapists' self‐assessment of effectiveness was not correlated with their actual effectiveness. The results of this study might indicate that therapists with high levels of self‐efficacy benefit from client feedback because it can correct their biases. However, for therapists with low self‐efficacy, client feedback might be less beneficial, possibly because it can make them more insecure. These hypotheses need to be investigated in future research.
Corporate social responsibility performance and the cost of capital in BRICS countries. The problem of selectivity using environmental, social and governance scores
Authors: Fandella Paola , Sergi Bruno S. , Sironi Emiliano 
Published: January 2023

AbstractThe paper aims to test whether corporate social responsibility (CSR) performance affects the costs of debt, equity, and a weighted average of those two components in BRICS countries. Theoretically, a decline in the cost of capital is linked to a decrease in the firm risk. We measure CSR performance using the environmental, social, and governance (ESG) combined score from the Thomson Reuters EIKON database for non‐financial enterprises between 2014 and 2019. A panel regression analysis has been run in order to test whether (1) the inclusion in the ESG combined ranking or (2) the level of the scores for ESG combines is linked to a decline in the cost of capital. Empirical evidence suggests that the level of the ESG combined score does not affect the firm's financial risk. Inclusion in the ESG combined index decreases the cost of equity and the average cost of capital instead. Firms that received an ESG combined score pay lower returns to investors.
Photoinduced Catalytic Organic‐Hydride Transfer to CO2 Mediated with Ruthenium Complexes as NAD+/NADH Redox Couple Models**
Authors: Kinoshita Yusuke , Deromachi Nagisa , Kajiwara Takashi , Koizumi Take‐aki , Kitagawa Susumu , Tamiaki Hitoshi , Tanaka Koji 
Published: January 2023

AbstractThe catalytic organic‐hydride transfer to CO2 was first achieved through the photoinduced two‐electron reduction of the [Ru(bpy)2(pbn)]2+/[Ru(bpy)2(pbnHH)]2+ (bpy=2,2’‐bipyridine, pbn=2‐(pyridin‐2‐yl)benzo[b]‐1,5‐naphthyridine, and pbnHH=2‐(pyridin‐2‐yl)‐5,10‐dihydrobenzo[b]‐1,5‐naphthyridine) redox couple in the presence of 1,3‐dimethyl‐2‐phenyl‐2,3‐dihydro‐1H‐benzo[d]imidazole (BIH). The active species for the catalytic hydride transfer to carbon dioxide giving formate is [Ru(bpy)(bpy⋅−)(pbnHH)]+ formed by one‐electron reduction of [Ru(bpy)2(pbnHH)]2+ with BI⋅.
Disentangling eating disorder diagnostic schemes. Commentary on Walsh et al., “A systematic review comparing atypical anorexia nervosa and anorexia nervosa”
Authors: Hay Phillipa 
Published: January 2023

AbstractThis commentary discusses the systematic review by Walsh et al. that has found that people with atypical anorexia nervosa have similar symptoms and severity as have people with anorexia nervosa. In this paper, the discussion is broadened to other eating disorders diagnoses and the problem of overlap and crossover between syndromes that impacts adversely on the need for diagnoses to be distinct both at assessment but also over time. It is argued that the derivation of eating disorder diagnostic criteria has also been vulnerable to erroneous assumptions and biased observations. Whether atypical anorexia nervosa becomes a standalone diagnosis or is joined with an expanded anorexia nervosa, future delineations should be based on empirical research including neuroscience.
Controlled Preparation of Hydrangea‐like 0.3Zn‐0.15Sn/CuO Catalysts for the Rochow‐Müller Reaction by Microwave‐Assisted Liquid‐Phase Synergistic Impregnation
Authors: Chen Fengyu , Yu Jie , Ding Xin , Hu Shuqiu , Yang Weitian , Li Shaoyuan , Ma Wenhui 
Published: January 2023

AbstractIn catalytic reactions, trace amounts of promoters can make up for the low activity of a catalyst and significantly affect the physicochemical properties of the catalyst. Exploring a simple and efficient composite Cu‐based catalyst is essential to the Rochow‐Müller reaction. In this work, monodisperse, a hydrangea‐like 0.3Zn‐0.15Sn/CuO composite catalyst in the Rochow‐Müller reaction. The composite was synthesized via a microwave‐assisted liquid‐phase synergistic impregnation method in which Sn and Zn were used to dope the CuO surface to create strong Si interaction points. A significant increase in the catalytic activity of CuO was observed after Sn and Zn doping, attributed to the rearrangement of charges on the CuO surface and increase in the Cu atom's core electron density. This work provided a novel and efficient method for preparing efficient Cu‐based catalysts for the Rochow‐Müller reaction.
Benzimidazolium‐Decorated Metalloporphyrin Molecule and Polymer: a Reliable Preparation Method and Application in Catalyzing the Cycloaddition Reaction of CO2and Epoxides
Authors: Yang Yong , Wang Qiang , Su Zhenping , Li Jun , Wang Ning 
Published: January 2023

AbstractDue to the synergistic effect of central metal and halide anion, cationic metalloporphyrins and derivatives exhibit outstanding catalytic activities for the cycloaddition reaction of epoxides and carbon dioxide. Herein, a generic strategy was developed to synthesize the benzimidazolium‐containing metalloporphyrin molecule and polymer. To demonstrate the method feasibility, we firstly synthesized the molecule1H, in which the benzimidazole groups were in‐site constructed by the cyclization of 5,10,15,20‐(4‐carboxyphenyl)‐porphyrin (H2TCPP) witho‐diaminobenzene (PEA). After post‐synthetic ionization and metallization, I−and Zn2+were introduced as the nucleophile and Lewis acid, respectively. The structure of1ZnILwas confirmed by single crystal X‐ray diffraction analysis. By using the similar conditions of model reaction,H2TCPPwas copolymerized with 1,2,4,5‐tetraaminobenzene (BTA) to prepare the polymerP‐1ZnIL. The prepared cationic molecule1ZnILand polymerP‐1ZnILshowed comparable activities in catalyzing the cycloaddition of carbon dioxide with epoxides to cyclic carbonates compared to the reported bifunctional catalysts based on metalloporphyrins.
Straightforward Access to Pyrazine‐(2,3)‐diones through Sequential Three‐Component Reaction
Authors: Mari Giacomo , De Crescentini Lucia , Favi Gianfranco , Santeusanio Stefania , Mantellini Fabio 
Published: January 2023

AbstractA novel protocol for the assembly of polysubstituted 2,3‐dioxo‐1,4,5,6‐tetrahydropyrazines and 2,3‐dioxo‐hydro‐1H‐cycloalkyl[b]pyrazines has been developed by the sequential three‐component reaction of primary aliphatic amines, 1,2‐diaza‐1,3‐dienes (DDs) and oxalyl chloride. This synthetic sequence proceeds by initial aza‐Michael addition of the amine to the azo‐ene compounds and subsequent ring closure involving the oxalyl chloride. The ready availability of the starting materials as well as the high level of practicability of the reaction and work‐up make this approach an attractive opportunity towards these uncommon systems.
Recent advances in layered double hydroxides‐based electrochemical sensors: Insight in transition metal contribution
Authors: Mousty Christine , Farhat Hani 
Published: January 2023

AbstractAmong the nanomaterials reported in the literature, layered double hydroxides (LDHs) are considered promising for the electrochemical sensor technology. Transition metal‐based layered double hydroxides (TM‐LDHs) show excellent electrocatalytic properties that facilitate redox reactions with analytes, e. g. H2O2, glucose or glyphosate. Elaboration of porous nano‐structures with TM‐LDHs nanosheets on the electrode surface allows a rapid diffusion of the analytes and a good accessibility of the TM active sites. An association of TM‐LDHs with conductive materials, e. g. graphene or metal nanoparticles (M‐NPs), improves the electronic conductivity in the LDH‐based composites and also the electrocatalytic activity. With a selection of recent publications, the present mini‐review aims to discuss about the specific electrocatalytic role played by TMs (Ni, Co, Cu, Mn and Fe) present in the LDH layers on the performance (sensitivity and detection limit) of these TM‐LDHs‐based sensors.