bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective outcome analysis of multiple sclerosis cases reveals candidate prognostic cerebrospinal fluid markers
Authors: Everest Elif , Uygunoglu Ugur , Tutuncu Melih , Bulbul Alper , Onat Umut Inci , Unal Mehmetcan , Avsar Timucin , Saip Sabahattin , Bilge Ugur , Turanli Eda Tahir , Siva Aksel 
Published: June 2023

Background
Predicting the long-term disability outcomes of multiple sclerosis (MS) cases is challenging.

Objective
We prospectively analysed our previous MS cohort with initial cerebrospinal fluid (CSF) proteomics data to reveal disability markers after 8.2±2.2 years of follow-up.

Methods
Patients with regular follow-up visits were assigned into two groups: those with an age-related MS severity (ARMSS) score ≥5 (unfavourable course group, N = 27) and ARMSS score <5 (favourable course group, N = 67). A machine learning-based algorithm was applied to reveal candidate poor prognosis-associated initial CSF proteins, which were measured in an independent MS cohort (verification group, N = 40) by ELISA. Additionally, the correlation of initial clinical and radiological parameters with long-term disability was analysed.

Results
CSF alpha-2-macroglobulin (P = 0.0015), apo-A1 (P = 0.0016), and haptoglobin (P = 0.0003) protein levels, as well as cerebral lesion load (>9 lesions) on magnetic resonance imaging, gait disturbance (P = 0.04), and bladder/bowel symptoms (P = 0.01) were significantly higher in the unfavourable course group than in the favourable course group. Optic nerve involvement evident on initial magnetic resonance imaging (P = 0.002) and optic neuritis (P = 0.01) were more frequent in the favourable course group.

Conclusion
The herein identified initial CSF protein levels, in addition to the clinical and radiological parameters at disease onset, have predictive value for long-term disability in MS cases.
Perceived impacts of COVID-19 and bushfires on the implementation of an obesity prevention trial in Northeast Victoria, Australia
Authors: Whelan Jillian , Hillenaar Monique , Fraser Penny , Allender Steven , Jackson Michelle , Strugnell Claudia , Bell Colin 
Published: June 2023

Background
Calls for the adoption of a systems approach to chronic disease prevention date back at least ten years because of the potential to empower communities to identify and address the complex causes of overnutrition, undernutrition and climate change. Australia, like many countries, has high levels of obesity and extreme climate events. The Reflexive Evidence and Systems interventions to Prevent Obesity and Non-communicable Disease (RESPOND) trial aims to prevent unhealthy weight gain in children in 10 intervention and two pilot communities in north-east Victoria, Australia using community-based participatory approaches informed by systems science. Intervention activities co-designed in 2019 were disrupted by COVID-19 and bushfires. This paper explores the impacts of these ‘shocks’ on the local prevention workforce to implement actions within communities.

Methods
A case study design involving one-hour online focus groups and an on-line survey (November 2021-February 2022). Purposive sampling was used to achieve diverse representation from RESPOND stakeholders including local council, health services, primary care partnerships and department of health. The focus group interview schedule and survey questions were based on Durlak and DuPre’s implementation factors.

Results
Twenty-nine participants from seven different communities participated in at least one of nine focus groups to discuss the impacts of COVID-19 and bushfires on localised implementation. Twenty-eight participants (97% of focus group sample) also completed the on-line survey. Implementation of RESPOND stalled or stopped in most communities due to bushfires and/or COVID-19. These shocks resulted in organisational priorities changing, loss of momentum for implementation, redeployment of human resources, culminating in fatigue and exhaustion. Participants reported adaptation of RESPOND, but implementation was slowed due to limited resources.

Conclusion
Further research is needed to advance risk management strategies and protect resources within health promotion. System shocks such as bushfires and COVID-19 are inevitable, and despite multiple adaptation opportunities, this intervention approach was not ‘shock proof’.
RETURN SPILLOVERS BETWEEN EMERGING MARKETS’ FINANCIAL STRESS AND EQUITY MARKETS OF BRIC-T COUNTRIES
Authors: GÜNAY Samet , ÖNER Mehtap , AYBARS Aslı 
Published: June 2023

This study explores the connectedness between selected emerging equity markets (BRIC-T) and the
Emerging Markets Financial Stress Index (EMFSI). We aim to reveal the extent of spillovers from stock
market indices to aggregated financial tension in these countries. Empirical investigations are executed
through Quantile Vector Autoregression analysis. Results show that spillovers occur mainly during extreme
negative and positive return periods. When we focus on four important phases, namely Global Financial
Crisis (GFC), the Euro Area Sovereign Debt Crisis, the COVID-19 pandemic, and the Russia-Ukraine war,
three countries come to the fore. While Brazil has had a substantial and persistent impact across the years,
during the GFC, two other countries, Russia and Türkiye, seem to induce positive return spillovers toward
emerging markets’ stress. This impact becomes bilateral in Russia (both in positive and negative returns)
during the pandemic and the Russia-Ukraine war. Thus, we conclude that among the examined market
economies, negative or positive return transmissions to emerging market stress are led mainly by Brazil and
Russia. The importance of energy sources and political factors can account for this result.
SDR16C5 promotes proliferation and migration and inhibits apoptosis in pancreatic cancer
Authors: Hong Kunqiao , Yang Qian , Yin Haisen , Zhang Jianwei , Yu Baoping 
Published: June 2023

Abstract
Pancreatic cancer (PAAD) is usually found when it is already in its advanced stage, which has limited options available for treatment and poor overall survival. The SDR16C5 gene is necessary for embryonic and adult tissue differentiation, development, and apoptosis, and it also participates in immune response and regulates energy metabolism. However, the role of SDR16C5 in PAAD remains unclear. In this study, we find that SDR16C5 was highly expressed in multiple tumors including PAAD. Furthermore, higher expression of SDR16C5 was significantly associated with poorer survival. We also find that the knockdown of SDR16C5 can inhibit PAAD cell proliferation and promote cell apoptosis by repressing Bcl-2, cleaved caspase 3, and cleaved caspase 9 protein expression. Moreover, silencing SDR16C5 inhibits the migration of PANC-1 and SW1990 cells by interrupting epithelial–mesenchymal transition. KEGG pathway analysis and immunofluorescence staining indicate that SDR16C5 is associated with immunity and may also participate in the development of PAAD through the IL-17 signaling pathway. Collectively, our findings provide evidence that SDR16C5 is overexpressed in PAAD patients and promotes its proliferation, migration, invasion, and apoptosis-inhibition of PAAD cells. Thus, SDR16C5 may be a potential prognostic and therapeutic target.
Foreign Investors and the Peer Effects to Payout Policies
Authors: Lee Jong Hwa , Seo Sung Won 
Published: June 2023

Abstract
This research studies the influence of foreign investors on payout policies and the peer effect of dividends. We show that peer effects on dividend policies exist in Korea using an instrumental variable approach. Additionally, our results suggest that foreign investor activities intensify the peer effect on dividend policies. Firms with a higher net purchase by foreign investors are more heavily scrutinized to reduce information asymmetry between managers and shareholders. This monitoring behavior affects dividend choices among firms and the responsiveness to peer influence. Further, the impact of foreign investors is prominent for dividend increases but not for decreases.
European Public Policies and Sovereign Risk in the Eurozone: How State-Contingent Governance Hampers Fiscal Discipline
Authors: van Riet Ad 
Published: June 2023

Abstract
The 30 years old Maastricht Treaty on European Union (EU) is based on the political vision that a stable euro requires sound budgetary policies and sustainable public finances in all the participating countries. This article reviews how the European framework for managing sovereign risk in the Economic and Monetary Union (EMU) has evolved in challenging times. The main finding is that over the years European policymakers have applied a range of special provisions contingent on the state of national economies, the demand for public investment, the need for a sound financial system, the effectiveness of monetary transmission, or on general concerns with the integrity of the eurozone, in a way which hampers fiscal discipline. The growing prominence of this state-contingent governance could mark the political transition from the Maastricht Treaty’s focus on public risk reduction to a ‘Next Generation EMU’ which favours public risk sharing. The challenge in designing the future EMU architecture will be to balance the need to preserve the integrity of eurozone with the need for fiscal discipline.
Dispersive surface-response formalism to address nonlocality in extreme plasmonic field confinement
Authors: Babaze Antton , Neuman Tomáš , Esteban Ruben , Aizpurua Javier , Borisov Andrei G. 
Published: June 2023

Abstract
The surface-response formalism (SRF), where quantum surface-response corrections are incorporated into the classical electromagnetic theory via the Feibelman parameters, serves to address quantum effects in the optical response of metallic nanostructures. So far, the Feibelman parameters have been typically obtained from many-body calculations performed in the long-wavelength approximation, which neglects the nonlocality of the optical response in the direction parallel to the metal–dielectric interface, thus preventing to address the optical response of systems with extreme field confinement. To improve this approach, we introduce a dispersive SRF based on a general Feibelman parameter d
⊥(ω, k
‖), which is a function of both the excitation frequency, ω, and the wavenumber parallel to the planar metal surface, k
‖. An explicit comparison with time-dependent density functional theory (TDDFT) results shows that the dispersive SRF correctly describes the plasmonic response of planar and nonplanar systems featuring extreme field confinement. This work thus significantly extends the applicability range of the SRF, contributing to the development of computationally efficient semiclassical descriptions of light–matter interaction that capture quantum effects.
Impact of substrates and quantum effects on exciton line shapes of 2D semiconductors at room temperature
Authors: van de Groep Jorik , Li Qitong , Song Jung-Hwan , Kik Pieter G. , Brongersma Mark L. 
Published: June 2023

Abstract
Exciton resonances in monolayer transition-metal dichalcogenides (TMDs) provide exceptionally strong light–matter interaction at room temperature. Their spectral line shape is critical in the design of a myriad of optoelectronic devices, ranging from solar cells to quantum information processing. However, disorder resulting from static inhomogeneities and dynamical fluctuations can significantly impact the line shape. Many recent works experimentally evaluate the optical properties of TMD monolayers placed on a substrate and the line shape is typically linked directly to the material’s quality. Here, we highlight that the interference of the substrate and TMD reflections can strongly influence the line shape. We further show how basic, room-temperature reflection measurements allow investigation of the quantum mechanical exciton dynamics by systematically controlling the substrate reflection with index-matching oils. By removing the substrate contribution with properly chosen oil, we can extract the excitonic decay rates including the quantum mechanical dephasing rate. The results provide valuable guidance for the engineering of exciton line shapes in layered nanophotonic systems.
Inquisition of micellar and surface active properties of gemini surfactants in the presence of a dipeptide
Authors: Kaur Jasmeet , Sharma Pooja , Kaur Gagandeep , Awasthi Pamita , Kumar Harsh , Kaur Ramanjeet 
Published: June 2023

Abstract
The influence of dipeptide glycyl-l-valine (gly-l-val) on the micellization and surface active properties of two different gemini surfactants varying in their spacer group i.e. ethylene-1,2-bis (N,N-dimethyl-N-dodecylammonium bromide) (12–2–12) and hexamethylene-1,6-bis-(N,N-dimethyl-N-dodecylammonium bromide) (12–6–12) was explored using tensiometry as well as conductivity technique. Conductivity measurements at several temperatures (293.15, 298.15, 303.15 and 308.15) K and tensiometric measurements at 298.15 K at several concentrations of dipeptide (0.02, 0.04 and 0.06) mol/kg were conducted so as to deduce the interactions amid dipeptide and two surfactants. Several parameters viz. critical micelle concentration (CMC) as well as the degree of ionization (α) along with various parameters associated with thermodynamics; standard entropy of micellization (

Δ

S
m
0

${\Delta}{S}_{m}^{0}$

), Gibbs free energy of micellization (

Δ

G
m
0

${\Delta}{G}_{m}^{0}$

) and standard enthalpy of micellization (

Δ

H
m
0

${\Delta}{H}_{m}^{0}$

) have been evaluated through conductivity data. Various additional thermodynamic parameters such as free energy of adsorption (

Δ

G

a
d

0

${\Delta}{G}_{ad}^{0}$

) and surface free energy

(
G

min
s

${\left(G\right.}_{\mathrm{min}}^{s}$

) have been also estimated through surface tension measurements.
The Gascon evolution of Latin ‑ll‑: A new theory
Authors: Zarabozo Carlos 
Published: June 2023

Abstract
In Gascon, Latin ‑ll‑ has evolved to the word‑medial result ‑r‑ and the secondarily word‑final result ‑t in most of Gascony, along with word‑final palatal variants. These results are generally assumed to have originated from a lost retroflex stage, paralleling existing retroflex results for ‑ll‑ in South Italian dialects and in Western Asturias. The present study offers an alternative theory by positing a delateralization of a lateral to a voiced non‑spirant alveolar stop *d, with no change in the point of articulation. The *d is shown to be an areal phenomenon in that it is the source of the Upper Aragonese ‑ll‑ results and is a sound that is found currently in some Basque dialects. The same theory of a non­spirant alveolar *d stage for ‑ll‑ explains the eventual presence of retroflexion in Western Asturias. While on the surface any Basque influence on the Gascon sound changes appears unlikely, this study shows that both the initial change to an alveolar stop, and the word‑final palatal results, can plausibly be attributed to Basque influence.
Los sistemas de nominativo del pronombre personal gallego
Authors: Alonso Núñez Aquilino Santiago 
Published: June 2023

Abstract
The present research addresses the nominative case systems of the Galician personal pronouns and shows the possibilities that the mapping of linguistic zones based on a system of elements opens up for Galician dialectology. The territory occupied by the different linguistic convergences and their contextualization in the Galician-Portuguese dialectal continuum are also investigated. In addition to the most relevant bibliography, data from the ALGa (Galician linguistic atlas) were used for the analysis of Galician as a whole, and surveys and recordings were implemented to study the particularities of Galician in the municipality of Castrelo do Val and the region of Verín. The convergences detected do not match the three linguistic blocks proposed by Galician dialectology. The nominative case system of the personal pronoun of the Irian diocese is the most commonly used but its use is not as large as the Western Block. The second largest system is the Auriense, but it is less than half the size of the Central Block. The other systems detected occupy smaller areas than the two already mentioned. Among them, we can find the system used in the municipality of Castrelo do Val and the prototypical form from Verín, which only departs from the main system of the Galician-Portuguese continuum in the use of el instead of ele and in the pronunciation of ela with a close-mid front vowel.
Luta Hegemônica e Populismo:Soluções Agonísticaspara o Desafio Identitário
Authors: Da Silva Mayra Goulart 
Published: June 2023

O objeto deste artigo é a abordagem neogramsciana de Chantal Mouffe e Ernesto Laclau. Centrada nos conceitos de luta hegemônica e populismo. Esta análise será realizada mediante uma genealogia que visa abordar as manifestações de ambas categorias na América Latina, correlacionando teoria e práxis. Após esse primeiro esforço, que objetiva situar a obra dos autores como um ponto de inflexão na tradição marxista, serão desenvolvidos três desdobramentos axiológicos desse movimento. O primeiro, diz respeito à relação entre o conceito de populismo e o marco teórico estabelecido em Hegemonia e Estratégia Socialista – por uma política democrática radical(1985). O segundo, apresenta tal formulação como uma síntese entre abordagens teóricas que ultrapassam os limites do marxismo. O terceiro movimento, por fim, salienta alguns riscos inerentes ao populismo enquanto operador que, embora possua uma afinidade com a contra-hegemonia, tem seu potencial emancipatório drenado pela excessiva ênfase na figura do líder.
As Paneleiras de Goiabeiras Velha e o “Outro” no processo de identificação dos sujeitos
Authors: Marques Marcelo de Souza 
Published: June 2023

A produção de artefatos cerâmicos em Goiabeiras, região central de Vitória, capital do Espírito Santo, Brasil, é de longa data. Trata-se de uma tradição indígena, cujos primeiros registros datam de 1815. Contudo, a partir de meados do século XX, artesãos do nordeste brasileiro passaram a se instalar no estado, dando origem a novos núcleos produtores. Entre os novos polos ceramistas, os Artesãos de Guarapari, migrantes pernambucanos, foram os que conseguiram se destacar na concorrência com as Artesãs de Goiabeiras. Tendo em vista esse contexto, o presente estudo tem como objetivo central compreender o processo de identificação das artesãs como Paneleiras de Goiabeiras-Velha. A hipótese sustenta que esse processo discursivo, além de envolver a construção discursiva de Goiabeiras-Velha como território da tradição, abarca a demarcação de uma posição diferencial em relação aos Artesãos de Guarapari.
From Motivation to Action: Action Cost Better Predicts Changes in Premovement Beta-Band Activity than Speed
Authors: Pierrieau Emeline , Berret Bastien , Lepage Jean-François , Bernier Pierre-Michel 
Published: June 2023

Although premovement beta-band event-related desynchronization (β-ERD; 13–30 Hz) from sensorimotor regions is modulated by movement speed, current evidence does not support a strict monotonic association between the two. Given that β-ERD is thought to increase information encoding capacity, we tested the hypothesis that it might be related to the expected neurocomputational cost of movement, here referred to as action cost. Critically, action cost is greater both for slow and fast movements compared with a medium or “preferred” speed. Thirty-one right-handed participants performed a speed-controlled reaching task while recording their EEG. Results revealed potent modulations of beta power as a function of speed, with β-ERD being significantly greater both for movements performed at high and low speeds compared with medium speed. Interestingly, medium-speed movements were more often chosen by participants than low-speed and high-speed movements, suggesting that they were evaluated as less costly. In line with this, modeling of action cost revealed a pattern of modulation across speed conditions that strikingly resembled the one found for β-ERD. Indeed, linear mixed models showed that estimated action cost predicted variations of β-ERD significantly better than speed. This relationship with action cost was specific to beta power, as it was not found when averaging activity in the mu band (8–12 Hz) and gamma band (31–49 Hz) bands. These results demonstrate that increasing β-ERD may not merely speed up movements, but instead facilitate the preparation of high-speed and low-speed movements through the allocation of additional neural resources, thereby enabling flexible motor control.SIGNIFICANCE STATEMENTHeightened beta activity has been associated with movement slowing in Parkinson's disease, and modulations of beta activity are commonly used to decode movement parameters in brain–computer interfaces. Here we show that premovement beta activity is better explained by the neurocomputational cost of the action rather than its speed. Instead of being interpreted as a mere reflection of changes in movement speed, premovement changes in beta activity might therefore be used to infer the amount of neural resources that are allocated for motor planning.
Epidemiology and Prevention of Child Pedestrian Injury
Authors: Kendi Sadiqa , Johnston Brian D. ,   COUNCIL ON INJURY, VIOLENCE, AND POISON PREVENTION, Hoffman Benjamin , Agran Phyllis F. , Culyba Alison , Dodington James , Lee Lois K. , McFadden Terri , Monroe Kathy , Tenenbein Milton , Quinlan Kyran , Beno Suzanne , Dixon Cinnamon , Dunn Laura , Midgett Jonathan D. , Miller Bethany , Qualters Judith , Kozial Bonnie 
Published: June 2023

This report supports policy recommendations in the accompanying policy statement “Child Pedestrian Safety” (www.pediatrics.org/cgi/doi/10.1542/peds.2023-62506). It reviews trends in public health and urban design relevant to pedestrian safety and provides information to assist practicing pediatricians discussing the benefits of active transportation and the specific risks and safety precautions to consider for child pedestrians at different ages. The report offers the evidence base for which programs and policies that, if implemented, could foster independent mobility for children while increasing pediatric pedestrian safety.
Since the previous policy statement was published in 2009, the field of pedestrian safety has advanced with new evidence related to pediatric pedestrian education, the risks of distracted walking, the benefits of design and programming in safe routes to school, and the emergence of the “Vision Zero” public health and safety initiatives to prevent all serious and fatal transportation injuries.
Hypertension in peri- and postmenopausal women — pathophysiological mechanisms and approaches to treatment
Authors: Baranova E. I. , Katsap A. A. , Kolesnik O. S. , Lebedeva E. V. 
Published: June 2023

This review presents epidemiological data on the effect of sex hormones and reproductive status on the level of blood pressure (BP) and the incidence of es­sential hypertension (EHT) in women. The role of estrogen deprivation and hyper­androgenism in the development of EHT in peri- and postmenopause is discussed. The main mechanisms of EHT in periand postmenopausal women: sympathetic and renin-angiotensin-aldosterone system hyperactivity, salt-sensitivity, high prevalence of abdominal obesity, metabolic syndrome, left ventricular hypertrophy, left atrial dilatation and high risk of atrial fibrillation, stroke and heart failure with preserved left ventricle ejection fraction. Data on the efficacy and tolerability of the main classes of antihypertensive drugs in women is presented. We discussed the mechanisms of selective I1-imidazoline receptor agonists and the results of cohort studies of moxonidine monotherapy and its combination with other antihypertensive drugs and hormonal menopausal therapy in peri- and post­menopausal women. Moxonidine reduces high blood pressure in peri- and postmenopausal women and has a beneficial effect on metabolic syndrome components, but is also effective in patients with hypertensive crises, especially with sympathetic hyperactivity.