bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysfunctions of innate and adaptive immune tumor microenvironment in Waldenström macroglobulinemia
Authors: Cholujova Danka , Beke Gabor , Hunter Zachary R. , Hideshima Teru , Flores Ludmila , Zeleznikova Tatiana , Harrachova Denisa , Klucar Lubos , Leiba Merav , Drgona Lubos , Treon Steven P. , Kastritis Efstathios , Dorfman David M. , Anderson Kenneth C. , Jakubikova Jana 
Published: December 2022

AbstractWaldenström macroglobulinemia (WM) is a rare subtype of non‐Hodgkin lymphoma characterized by malignant lymphoplasmacytic cells in the bone marrow (BM). To dissect the pathophysiology of WM, we evaluated clonal cells by mapping of B cell lymphomagenesis with adaptive and innate immune tumor microenvironment (TME) in the BM of WM patients using mass cytometry (CyTOF). In‐depth immunophenotypic profiling of WM cells exhibited profound expansion of clonal cells in both unswitched and switched memory B cells and also plasma cells with aberrant expression variations. WM B lymphomagenesis was associated with reduction of most B cell precursors assessed with the same clonally restricted light chain and phenotypic changes. The immune TME was infiltrated by mature monocytes, neutrophils and adaptive T cells, preferentially subsets of effector T helper, effector CTL and effector memory CTL cells that were associated with superior overall survival (OS), in contrast to progenitors of T cells and myeloid/monocytic lineage subsets that were suppressed in WM cohort. Moreover, decrease in immature B and NKT cells was related to worse OS in WM patients. Innate and adaptive immune subsets of WM TME were modulated by immune checkpoints, including PD‐1/PD‐L1&PD‐L2, TIGIT/PVR, CD137/CD137‐L, CTLA‐4, BTLA and KIR expression. The response of ibrutinib treatment to the reduction of clonal memory B cell was associated with high levels of immature B cells and effector memory CTL cells. Our study demonstrates that CyTOF technology is a powerful approach for characterizing the pathophysiology of WM at various stages, predicting patient risk and monitoring the effectiveness of treatment strategies.
The WID‐EC test for the detection and risk prediction of endometrial cancer
Authors: Barrett James E. , Jones Allison , Evans Iona , Herzog Chiara , Reisel Daniel , Olaitan Adeola , Mould Tim , MacDonald Nicola , Doufekas Konstantinos , Newton Claire , Crosbie Emma J. , Bjørge Line , Colombo Nicoletta , Dostalek Lukas , Costas Laura , Peremiquel‐Trillas Paula , Ponce Jordi , Matias‐Guiu Xavier , Zikan Michal , Cibula David , Wang Jiangrong , Sundström Karin , Dillner Joakim , Widschwendter Martin 
Published: December 2022

AbstractThe incidence of endometrial cancer is rising. Measures to identify women at risk and to detect endometrial cancer earlier are required to reduce the morbidity triggered by the aggressive treatment required for advanced endometrial cancer. We developed the WID‐EC (Women's cancer risk IDentification‐Endometrial Cancer) test, which is based on DNA methylation at 500 CpG sites, in a discovery set of cervical liquid‐based cytology samples from 1086 women with and without an endometrial cancer (217 cancer cases and 869 healthy controls) with a worse prognosis (grade 3 or ≥stage IB). We validated the WID‐EC test in an independent external validation set of 64 endometrial cancer cases and 225 controls. We further validated the test in 150 healthy women (prospective set) who provided a cervical sample as part of the routine Swedish cervical screening programme, 54 of whom developed endometrial cancer within 3 years of sample collection. The WID‐EC test identified women with endometrial cancer with a receiver operator characteristic area under the curve (AUC) of 0.92 (95% CI: 0.88‐0.97) in the external set and of 0.82 (95% CI: 0.74‐0.89) in the prospective validation set. Using an optimal cutoff, cancer cases were detected with a sensitivity of 86% and a specificity of 90% in the external validation set, and a sensitivity and specificity of 52% and 98% respectively in the prospective validation set. The WID‐EC test can identify women with or at risk of endometrial cancer.
Rates of instrumental vaginal birth and cesarean and quality of maternal and newborn health care in private versus public facilities: Results of the IMAgiNE EURO study in 16 countries
Authors: Lazzerini Marzia , Valente Emanuelle Pessa , Covi Benedetta , Rozée Virginie , Costa Raquel , Otelea Marina Ruxandra , Abderhalden‐Zellweger Alessia , Węgrzynowska Maria , Linden Karolina , Arendt Maryse , Brigidi Serena , Miani Céline , Pumpure Elizabete , Radetic Jelena , Drandic Daniela , Cerimagic Amira , Nedberg Ingvild Hersoug , Liepinaitienė Alina , Rodrigues Carina , de Labrusse Claire , Baranowska Barbara , Zaigham Mehreen , Castañeda Lara Martín , Batram‐Zantvoort Stephanie , Jakovicka Dārta , Ruzicic Jovana , Juciūtė Simona , Santos Teresa , Gemperle Michael , Tataj‐Puzyna Urszula , Elden Helen , Mizgaitienė Marija , Lincetto Ornella , Sacks Emma , Mariani Ilaria ,   IMAgiNE EURO study group
Published: December 2022

AbstractObjectiveTo explore the quality of maternal and newborn care (QMNC) during the COVID‐19 pandemic by facility type among 16 European countries, comparing rates of instrumental vaginal birth and cesarean.MethodsWomen who gave birth in the WHO European Region from March 1, 2020, to February 7, 2022, answered a validated online questionnaire. Rates of instrumental birth, instrumental vaginal birth, and cesarean, and a QMNC index were calculated for births in public versus private facilities.ResultsResponses from 25 206 participants were analyzed. Women giving birth in private compared with public facilities reported significantly more frequent total cesarean (32.5% vs 19.0%; aOR 1.70; 95% CI 1.52–1.90), elective cesarean (17.3% vs 7.8%; aOR 1.90; 95% CI 1.65–2.19), and emergency cesarean before labor (7.4% vs 3.9%; aOR 1.39; 95% CI 1.14–1.70) (P < 0.001 for all comparisons), with analyses by country confirming these results. QMNC index results were heterogeneous across countries and regions in the same country and were largely affected by geographical distribution of regions rather than by type of facility alone.ConclusionThe study confirms that births in private facilities have higher odds of cesarean. It also suggests that QMNC should be closely monitored in all facilities to achieve high‐quality care, independent of facility type or geographical distribution.ClinicalTrials.gov Identifier
NCT04847336
The design of compounds with desirable properties – The anti‐HIV case study
Authors: Novak Jurica , Pathak Prateek , Grishina Maria A. , Potemkin Vladimir A. 
Published: December 2022

AbstractEfficacy and safety are among the most desirable characteristics of an ideal drug. The tremendous increase in computing power and the entry of artificial intelligence into the field of computational drug design are accelerating the process of identifying, developing, and optimizing potential drugs. Here, we present novel approach to design new molecules with desired properties. We combined various neural networks and linear regression algorithms to build models for cytotoxicity and anti‐HIV activity based on Continual Molecular Interior analysis (CoMIn) and Cinderella's Shoe (CiS) derived molecular descriptors. After validating the reliability of the models, a genetic algorithm was coupled with the Des‐Pot Grid algorithm to generate new molecules from a predefined pool of molecular fragments and predict their bioactivity and cytotoxicity. This combination led to the proposal of 16 hit molecules with high anti‐HIV activity and low cytotoxicity. The anti‐SARS‐CoV‐2 activity of the hits was predicted.
Revival of psychology in former Czechoslovakia and the contemporary Czech Republic after the fall of Totalitarian communist regimes
Authors: Heller Daniel 
Published: December 2022

AbstractAfter the general societal and political change in November 1989 in Czechoslovakia, the subject “History of Psychology” became the stable component of curriculum of studying psychology at the Department of Psychology of Faculty of Arts of Charles University in Prague. The author of this paper has taught “History of Psychology” in Czech since 1998 for more than 20 years all students of psychology and he is teaching this subject the students of ERASMUS+ program from whole Europe, studying at Charles University in Prague, now. Indivisible part of the curriculum is represented by the history of Czechoslovak and Czech psychology. In References, the most important publications in the field of history of Czechoslovak and Czech psychology are presented.
Cat‐Ear‐Line: A Sonographic Sign of Cortical Development?
Authors: Matsuzawa Nana , Poon Liona C. , Machida Megumi , Nakamura Takako , Uenishi Kohtaro , Wah Yi Man , Moungmaithong Sakita , Itakura Atsuo , Chiyo Hideaki , Pooh Ritsuko K. 
Published: December 2022

ObjectivesDiagonal echogenic lines outside the lateral ventricle have often been observed in the anterior coronal planes of the normal fetal brain by neurosonography. We have observed abnormal shapes of these echogenic lines in cases of malformation of cortical development (MCD). We named the ultrasound finding “cat‐ear‐line” (CEL). This study aimed to examine how and when CEL develops in normal cases compared with MCD cases.MethodsWe retrospectively examined the fetal brain volume dataset acquired through transvaginal 3D neurosonography of 575 control cases and 39 MCD cases from 2014 to 2020. We defined CEL as the hyperechogenic continuous lines through subplate (SP) and intermediate zone (IZ), pre‐CEL as the lines that existed only within the SP, and abnormal CEL as a mass‐like or mosaic shadow‐like structure that existed across the SP and IZ. All fetuses in the MCD group had some neurosonographic abnormalities and were ultimately diagnosed with MCD.ResultsThe CEL was detected in 97.9% (369/377) of the control group from 19 to 30 weeks. The CEL visualization rate of the MCD group in the same period was 40.0% (14/35) which was significantly lower than that of the control group (P < .001).ConclusionsFrom this study, it appears that the CEL is an ultrasound finding observed at and beyond 19 weeks in a normally developing fetus. In some MCD cases, pre‐CEL at and beyond 19 weeks or abnormal CEL was observed. Maldeveloped CEL at mid‐trimester may help identify cases at‐risk of subsequent MCD.
Usability of Real‐Time Elastography for the Diagnosis of Primary Open Angle and Pseudoexfoliation Glaucoma
Authors: Incekalan Tuğba Kurumoğlu , Peköz Burçak Çakır 
Published: December 2022

ObjectivesThis study aims to investigate real‐time elastography (RTE) use in the evaluation of the optic nerve head (ONH) and peripapillary structures for the diagnosis of primary open angle (POAG) and pseudoexfoliation (PEX) glaucoma.MethodsThis case–controlled study included 30 patients with POAG, 30 patients with PEX glaucoma, and 30 age‐matched control subjects. All of the participants underwent comprehensive ophthalmological examinations covering vessel density of optic nerve and retinal nerve fiber layer (RNFL) thickness measurements with optical cohorence tomography angiography and mean deviation (MD) measurements with Humphrey II Perimetry Visual Field Analyzer. In vivo evaluation of the biomechanical properties of the ONH and peripapillary structures were performed with RTE in all participants.ResultsWe observed higher ratios of orbital fat to optic nerve head (ROFON) values (P = .008) and strain ratios of orbital fat to scleral–choroidal–retinal complex (ROFSCR) values (P = .004) in the POAG group compared with PEX glaucoma group and higher ROFON (P = .012) and ROFSCR values (P = .004) in PEX glaucoma group than the control group. ROFON and ROFSCR values were positively correlated with glaucoma duration and negatively correlated with MD, radial peripapillary vessel density (RPCVD), and inside disc vessel density in both glaucoma groups (P < .005; only in the PEX glaucoma group for MD and ROFSCR, P = .445).ConclusionDetermining the biomechanical properties of ONH and peripapillary structures with RTE in glaucomatous eyes may offer a new perspective on the diagnosis and follow‐up of the progression of the disease.
Acoustic Screening of the “Wet voice”: Proof of Concept in an ex vivo Canine Laryngeal Model
Authors: Rameau Anaïs , Andreadis Katerina , Ganesan Vinayak , Lachs Mark S , Rosen Tony , Wang Fei , Maddox Alexandra , Klinck Holger , Khosla Sid M. , de Luzan Charles Farbos , Madhusudhana Shyam 
Published: December 2022

BackgroundCurrent protocols for bedside swallow evaluation have high rates of false negative results. Though experts are not consistently able to screen for aspiration risk by assessing vocal quality, there is emerging evidence that vocal acoustic parameters are significantly different in patients at risk of aspiration. Herein, we aimed to determine whether the presence of material on the vocal folds in an excised canine laryngeal model may have an impact on acoustic and aerodynamic measures.MethodsTwo ex vivo canine larynges were tested. Three liquids of different viscosities (1:100 diluted glycerin, pure glycerin, and honey‐thick Varibar) were placed on the vocal folds at a constant volume. Acoustic and aerodynamic measures were obtained in both adducted and abducted vocal fold configurations. Intraglottal high‐speed imaging was used to approximate the maximum divergence angle of the larynges in the studied conditions and examine its relationship to vocal efficiency (VE) and acoustic measures.ResultsIn glottic insufficiency conditions only, we found that several acoustic parameters could predict the presence of material on the vocal folds. Based on the combination of the aerodynamic and acoustic data, we found that decreased spectral energy in the higher harmonics was associated with decreased VE in the presence of material on the vocal folds and/or glottic insufficiency.ConclusionDecreased spectral energy in the higher harmonics of the voice was found to be a potential biomarker of swallowing dysfunction, as it correlates with decreased vocal efficiency due to material on the vocal folds and/or glottic insufficiency, both of which are known risk factors for aspiration.Level of EvidenceNA Laryngoscope, 133:2517–2524, 2023
Nanoplasmon‐Nanoplasma Transition in Cu Nanoparticle: Distinction of Electron Emission
Authors: Huang Xiang , Huang Hao , Han Xu , Cao Wei , Zhang Qingbin , Lu Peixiang 
Published: December 2022

AbstractThe electron response of nanoplasmon and nanoplasma in the laser field is greatly important for improving the functionality and efficiency of many potential applications. However, how and under what conditions the nanoplasmon‐nanoplasma transition works remains poorly understood due to radiation damage and charge buildup. Utilizing the combined aerodynamic lens and velocity map imaging spectrometer, this transition mediated by different mechanisms are demonstrated, as verified by the distinct photoelectron momentum distributions from Cu nanoparticles. Initially the polarization‐dependent distributions emphasize the domination of surface emission driven by the plasmonic field. Subsequently the transition starts and the competition of volume‐multiphoton and thermionic emission plays the intermediate state dominating the transition process. Finally, a complete plasma is generated with the leading role of thermionic emission, which is confirmed by first observing the correlated electronic decay in metal nanoparticles. These findings bridge the gap between electron emission in nanoplasmonic and nanoplasma states and identify the mechanism‐specific contributions, which will offer general principles for designing nanostructure and laser fields to control electron excitation and emission in practice.
How celebrity status and gaze direction in ads drive visual attention to shape consumer decisions
Authors: D'Ambrogio Simone , Werksman Noah , Platt Michael L. , Johnson Elizabeth N. 
Published: December 2022

AbstractMarketers have long used celebrity endorsement to help viewers build strong brand‐product associations. Celebrity endorsements increase brand awareness and recall, but how celebrity endorsements shape the decision process remains unclear. A wealth of research indicates that people tend to follow someone else's gaze, yet its effects in advertisements have been largely unexplored. We recruited 77 participants to investigate the effect of celebrities and gaze‐cueing in advertisements on both gaze behavior and binary choices. We combined computational modeling with eye‐tracking and pupillometry to identify which internal components of processing are affected by celebrity endorsement. We found that gaze‐cueing and celebrity endorsement influence gaze allocation and option selection. Further, results from computational modeling, eye‐tracking, and pupillometry revealed that the effect of celebrity endorsement on decisions can be explained as an offset in the starting point of an evidence accumulation process as well as changes in the rate of accumulation, thereby biasing choice.
The role of histone deacetylases in embryonic development
Authors: Dsilva Priyanka , Pai Padmini , Shetty Manasa Gangadhar , Babitha Kampa S. 
Published: December 2022

AbstractThe basic units of chromatin are nucleosomes, that are made up of DNA wrapped around histone cores. Histone lysine residue is a common location for posttranslational modifications, with acetylation being the second most prevalent. Histone acetyltransferases (HATs/KATs) and histone deacetylases (HDACs/KDACs) regulate histone acetylation, which is important in gene expression control. HDACs/KDACs regulate gene expressions through the repression of the transcription machinery. HDAC/KDAC isoforms play a major role during various stages of embryo development and neurogenesis. In specific, class I and II HDACs/KDACs are involved in cardiac muscle differentiation and development. An insight into different pathways and genes associated with embryonic development, the effect of HDAC/KDAC activity during the embryonic stem cell differentiation, preimplantation, embryo development, gastrulation, and the role of different HDAC/KDAC inhibitors during the process of embryogenesis is summarized in the present review article.
Numerical analysis of two decoupled algorithms for a parabolic two domain problem
Authors: Shan Li , Zhang Haicheng 
Published: December 2022

AbstractTo investigate the fluid–fluid interaction problem, we study two first‐order in time, decoupled algorithms for a coupling system. This system consist of two heat equations, which are coupled by a condition that allows energy to pass back and forth across the interface. The first scheme is a combination of the three‐level implicit method with the coupling terms treated by the explicit leap‐frog method. Under a time step size condition, we prove that it is stable and first‐order convergent. To remove the time step size condition, we modify the treatment of the coupling interface term and propose a second scheme. Instead of making the interface term explicitly, we only lag the variable in the different subdomain onto the previous time step. As expected, the second scheme is proved to be stable and convergent unconditionally. Since both schemes only require the solution of two decoupled heat equations at each time step. Hence, they are efficient in computation and can be easily implemented by using legacy codes. The numerical tests also confirm our theoretical results.
Highly accurate difference schemes for time‐nonlocal Schrodinger type problems
Authors: Ashyralyev Allaberen , Sirma Ali , Ashyralyyev Charyyar 
Published: December 2022

AbstractIn this study, time‐nonlocal Schrodinger type problems are investigated. Single step absolute stable highly accurate difference schemes for the numerical solution of these problems are presented and theorems on the stability of these difference schemes are established. Numerical illustrations in test examples for the third and fourth order of accuracy difference schemes are presented.
Middle and high school teachers' perceptions of cyberbullying prevention and digital citizenship
Authors: Fredrick Stephanie S. , Coyle Samantha , King Jay'ana 
Published: December 2022

AbstractCyberbullying is a significant public health concern that has been associated with negative outcomes. The pandemic has increased the reliance on technology in the classroom; thus, research exploring cyberbullying in the classroom is even more important. Furthermore, it is important to understand teachers' perceptions of cyberbullying to inform efforts to support teachers in addressing cyberbullying. With a nationally representative sample of 174 teachers in the United States, a series of questionnaires were administered to investigate teachers' perceptions of cyberbullying, their preparedness to address cyberbullying, perceptions of effective strategies to address cyberbullying and whether social‐emotional learning programs used in their schools incorporate digital citizenship skills. Results indicated little change in the rates of cyberbullying in schools, but that teachers reported a need for training and professional development to best support them on this topic. Implications related to teacher educator preparation programs and school based interventions targeting cyberbullying are discussed.
Large‐eddy simulation of soil moisture heterogeneity‐induced secondary circulation with ambient winds
Authors: Zhang Lijie , Poll Stefan , Kollet Stefan 
Published: December 2022

AbstractLand surface heterogeneity in conjunction with ambient winds influences the convective atmospheric boundary layer by affecting the distribution of incoming solar radiation and forming secondary circulations. This study performed coupled large‐eddy simulation (ICON‐LEM) with a land surface model (TERRA‐ML) over a flat river corridor mimicked by soil moisture heterogeneity to investigate the impact of ambient winds on secondary circulations. The coupled model employed double‐periodic boundary conditions with a spatial scale of 4.8 km. All simulations used the same idealized initial atmospheric conditions with constant incident radiation of 700 W⋅m−2 and various ambient winds with different speeds (0 to 16 m⋅s−1) and directions (e.g., cross‐river, parallel‐river, and mixed). The atmospheric states are decomposed into ensemble‐averaged, mesoscale, and turbulence. The results show that the secondary circulation structure persists under the parallel‐river wind conditions independently of the wind speed but is destroyed when the cross‐river wind is stronger than 2 m⋅s−1. The soil moisture and wind speed determine the influence on the surface energy distribution independent of the wind direction. However, secondary circulations increase advection and dispersive heat flux while decreasing turbulent energy flux. The vertical profiles of the wind variance reflect the secondary circulation, and the maximum value of the mesoscale vertical wind variance indicates the secondary circulation strength. The secondary circulation strength positively scales with the Bowen ratio, stability parameter (−Zi/L), and thermal heterogeneity parameter under cross‐river wind and mixed wind conditions. The proposed similarity analyses and scaling approach provide a new quantitative perspective on the impact of the ambient wind under heteronomous soil moisture conditions on secondary circulation.