bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting adolescents as agents of change for an entomophageous future
Authors: Marquis D. 
Published: July 2023

AbstractAs food supply practices must adapt to the reality of limited natural resources, alternative solutions must be found to meet the dietary needs of a growing world population. Edible insect consumption represents a sustainable substitute to that of conventional meat. Psychological barriers are largely responsible for dictating Westerners’ aversion towards insect eating. As adolescents have been less exposed to socio‐cultural constructs and as their food habits are less entrenched, they might express a greater openness towards edible insect products. This study aims to assess the impact of exposure and familiarisation with edible insects on adolescents' attitudes towards entomophagy. Between February 2018 and January 2020, 662 students aged 15–16 years from a Canadian high school engaged in a pedagogical insect farming project during which they had the chance to learn about insects as a sustainable foodstuff, while being familiarised with insect farming methods. Three different student cohorts took part in this project. The first and second had the opportunity to raise crickets and the third mealworms. Relying on surveys distributed before and after these 3 month projects, time‐based and type‐based analyses regarding students’ initial attitudes towards edible insects and their evolution over the course of these activities were performed. Results showed that the project greatly enhanced their acceptance towards edible insect consumption, suggesting that the speed and impact of peer influence amongst adolescents could be leveraged in promotional efforts to accelerate the adoption of edible insects.
A comprehensive quality evaluation method of different medicinal parts of Physalis Calyx seu Fructus by fingerprints, chemometrics, antioxidant activity, network pharmacology and molecular docking
Authors: Liu Meiqi , Liu Guoqiang , Ma Zicheng , Wen Jin Li , Liu Yi , Sun Lili , Ren Xiaoliang 
Published: July 2023

AbstractPhysalis Calyx seu Fructus (PCF) is a herb widely used in China for its function of clearing heat and detoxifying, benefitting the pharynx and reducing phlegm, both in health care and in tea drinking. However, the quality of its fruit and calyx is uneven and the storage period is short. Therefore, it is crucial to develop other parts of PCF with longer storage periods and obvious medicinal effects. Firstly, high‐performance liquid chromatography was used to develop the fingerprint of different parts of PCF, and various chemometric analyses were conducted to screen out chemical markers. The calyxes of PCF were found to cluster together, distinct from the fruits, roots, stems and leaves. The active components of PCF were concentrated in the persistent calyxes, and flavonoids were mainly found in the persistent calyxes and leaves. Secondly, the extraction of persistent calyxes showed the strongest scavenging ability of DPPH and ABTS. Finally, the important chemical markers were verified by network pharmacological analysis and molecular docking. It provides a reference for the clinical application of PCF, and the obtained chemical markers offer a scientific basis for quality evaluation.
Selective and Sustainable Production of Sub‐terminal Hydroxy Fatty Acids by a Self‐Sufficient CYP102 Enzyme from Bacillus Amyloliquefaciens
Authors: Zong Li , Zhang Yan , Shao Zhengkang , Ljubic Anita , Jacobsen Charlotte , Gao Renjun , Eser Bekir Engin , Wang Yingwu , Guo Zheng 
Published: July 2023

AbstractEnzymatic hydroxylation of fatty acids by Cytochrome P450s (CYPs) offers an eco‐friendly route to hydroxy fatty acids (HFAs), high‐value oleochemicals with various applications in materials industry and with potential as bioactive compounds. However, instability and poor regioselectivity of CYPs are their main drawbacks. A newly discovered self‐sufficient CYP102 enzyme, BAMF0695 from Bacillus amyloliquefaciens DSM 7, exhibits preference for hydroxylation of sub‐terminal positions (ω‐1, ω‐2, and ω‐3) of fatty acids. Our studies show that BAMF0695 has a broad temperature optimum (over 70 % of maximal enzymatic activity retained between 20 to 50 °C) and is highly thermostable (T50 >50 °C), affording excellent adaptive compatibility for bioprocesses. We further demonstrate that BAMF0695 can utilize renewable microalgae lipid as a substrate feedstock for HFA production. Moreover, through extensive site‐directed and site‐saturation mutagenesis, we isolated variants with high regioselectivity, a rare property for CYPs that usually generate complex regioisomer mixtures. BAMF0695 mutants were able to generate a single HFA regiosiomer (ω‐1 or ω‐2) with selectivities from 75 % up to 91 %, using C12 to C18 fatty acids. Overall, our results demonstrate the potential of a recent CYP and its variants for sustainable and green production of high‐value HFAs.
Novel transcatheter intervention for iatrogenic cyanosis due to surgical rerouting of inferior vena cava to the left atrium
Authors: Sagar Pramod , Pavithran Sreeja , Sivakumar Kothandam 
Published: July 2023

AbstractImproper identification of the atrial septal defect margins during surgery and inadvertent suturing of the surgical patch to the Eustachian valve of the inferior vena cava (IVC) results in the diversion of inferior venacaval blood to the left atrium causing cyanosis. This complication has been dealt so far with surgery. We report the planning and implementation of a novel transcatheter rediversion of the IVC to the right atrium using a covered stent.
Activity and Durability Patterns of 45 Binary Noble Metal Alloy Nanoparticle Variants for Commercial Diesel Exhaust Aftertreatment
Authors: Siebeneicher Simon , Reichenberger Sven , Hengst Christoph , Dornhaus Franz , Wittek Bernd , Barcikowski Stephan 
Published: July 2023

AbstractCommercial diesel oxidation catalysis mainly uses monometallic and bimetallic Pt−Pd‐based catalysts, but alloying with different elements has rarely been done systematically under industrial testing conditions. 45 binary alloys made of platinum and a selected 1stand 2nd‐row transition metal, platinum group element, or coin metal were synthesized via a scalable laser synthesis method. Then, catalytic performance and durability were evaluated for one diesel oxidation and two ammonia‐slip environments. The results show the highest activity when the adsorption enthalpy of molecular oxygen of the alloy was similar to the value of Pt. Furthermore, the durability of the alloy catalysts was found to increase with the melting point of the 2ndelement Pt was alloyed with, even at molar fractions. Our results further indicate beneficial synergies beyond the binary systems underlining the possibility of further improvements by considering ternary or multinary alloys, which are accessible via laser synthesis.
Emergence of Ag as a Catalyst of Choice for Fluorination and Trifluoromethylation Reactions
Authors: Kumar Pradeep , Goel Nikita , Bhagat Sunita 
Published: July 2023

AbstractCarbon‐fluorine bond being highly polar in nature, its presence in pharmaceutically active molecules has huge impact on their chemical and physical properties. However, fluorine being highly electronegative and small in size, limits its nucleophilicity to the large extent; hence the incorporation of fluorine in the organic molecules is not an easy task. Due to this, demand for a suitable catalyst for fluorination reaction has been raised, which lowers the activation energy of these reactions and makes C−F/CF3 bond formation reaction kinetically more feasible. Silver being a late transition metal catalyst has been efficiently used to catalyze several reactions in the organic chemistry and has the substantial potential to catalyze the fluorination reactions. This Review shows the silver catalyzed fluorination and trifluoromethylation reactions for the synthesis of F/CF3 containing aromatic, aliphatic and heterocyclic compounds. All the sections have been elaborated using general discussion of the method, exploration of substrate scope, insight into the mechanistic studies and the shortcomings of the methods. After reading this Review article the readers can develop a detailed understanding of concept of silver metal catalyzed fluorination and trifluoromethylation reactions which can be explored for synthesizing molecules of biological interest.
Nanotechnology for High‐Performance Textiles: A Promising Frontier for Innovation
Authors: Syduzzaman Md. , Hassan Abir , Anik Habibur Rahman , Akter Mahin , Islam Md. Rashedul 
Published: July 2023

AbstractNanotechnology embodies a groundbreaking innovation for the textile and apparel industry, facilitating enhancements to the functionality and performance of textiles, including durability, resistance to water, odor, flame, stain, UV‐protection, and antimicrobial properties. Nanotechnology also enables biosensing, drug delivery, energy generation, and storage in textiles. Here, we present a comprehensive overview of the possibilities offered by nanotechnology in the context of high‐performance textiles providing a roadmap for future research and development in this exciting field. We scrutinize the current research on nanotechnology in textiles, exploring various types of nanomaterials and their properties, the methods of incorporating nanomaterials into textiles, and the numerous applications of high‐performance textiles across critical industries such as healthcare, military, sports, fashion, and wearable electronics. We conclude the review with an analysis of the potential health and environmental concerns arising from the use of nanotechnology in textiles, emphasizing the importance of further research in these areas.
Chemical characterization and biological abilities of Anthocleista djalonensis collected from two locations of Ivory Coast
Authors: Sinan Kouadio Ibrahime , Zengin Gokhan , Uba Abdullahi Ibrahim , Caprioli Giovanni , Angeloni Simone , Vittori Sauro , Jugreet Sharmeen , Etienne Ouattara Katinan , Shariati Mohamad Ali , Mahomoodally Mohamad Fawzi 
Published: July 2023

AbstractIn this study, the total phenolic and flavonoid contents, HPLC‐DAD detected phytochemicals, antioxidant and enzyme inhibitory potential of methanolic and aqueous (as infusion) extracts of the medicinal plant, Anthocleista djalonensis (leaf and stem bark) collected from two locations, Mafiblé and Prikro, in Ivory Coast, were investigated. The ranges of total phenolic and flavonoid contents obtained were 14.17–46.95 mg gallic acid equivalent (GAE)/g and 2.96–34.76 mg rutin equivalent (RE)/g, respectively. Antioxidant abilities in terms of radical scavenging, reducing and metal chelating activity of the extracts in different assays were as follows: DPPH (4.90–48.82 mg trolox equivalent [TE]/g), ABTS (21.05–81.89 mg TE/g), CUPRAC (29.54–122.33 mg TE/g), FRAP (17.53–94.06 mg TE/g) and metal chelating (10.09–28.49 mg EDTAE/g. The extracts of A. djalonensis collected from Mafiblé, especially those of stem bark, contained higher level of total bioactive contents compared to Prikro extracts, detected by high‐performance liquid chromatography with photodiode‐array detection (HPLC‐DAD). Only the methanolic extracts irrespective of plant parts/location, showed inhibition against acetylcholinesterase (1.42–2.12 mg galantamine equivalent (GALAE)/g), while only the stem bark methanolic extract of A. djalonensis from Mafiblé was found to inhibit butyrylcholinesterase (0.65 mg GALAE/g). Thus, findings from this study could be useful for better application of the medicinal benefits from this plant.
Interleukin‐1 blockade in heart failure: an on‐treatment and off‐treatment cardiorespiratory fitness analysis
Authors: Moroni Francesco , Golino Michele , Carbone Salvatore , Trankle Cory , Del Buono Marco Giuseppe , Talasaz Azita , Arena Ross , Canada Justin M. , Biondi‐Zoccai Giuseppe , Van Tassel Benjamin , Abbate Antonio 
Published: July 2023

AbstractAimsInterleukin‐1 (IL‐1) blockade may improve exercise capacity in patients with heart failure (HF) patients. The extent of the improvement and its persistence beyond discontinuation of IL‐1 blockade is unknown.Methods and resultsThe primary objective was to determine changes in cardiorespiratory fitness and cardiac function on‐treatment with IL‐1 blocker, anakinra, and off‐treatment, after treatment cessation. We performed cardiopulmonary exercise testing, Doppler echocardiography, and biomarkers in 73 patients with HF, 37 (51%) females, 52 (71%) Black–African–American, before and after treatment with anakinra 100 mg daily. In a subset of 46 patients, testing was also repeated after treatment cessation. Quality of life was assessed in each patient using standardized questionnaires. Data are presented as median and interquartile range. Treatment with anakinra for 4 [2–12] weeks was associated with a significant improvement in high‐sensitivity C‐reactive protein (from 6.2 [3.3–15.4] to 1.4 [0.8–3.4] mg/L, P < 0.001), peak oxygen consumption (VO2peak, from 13.9 [11.6–16.6] to 15.2 [12.9–17.4] mL/kg/min, P < 0.001). Ventilatory efficiency, exercise time, Doppler‐derived signs and biomarkers of elevated intracardiac pressures, and quality‐of‐life measures also improved with anakinra. In the 46 patients in whom off‐treatment data were available 12 [4–12] weeks later, many of the favourable changes seen with anakinra were largely reversed (from 1.5 [1.0–3.4] to 5.9 [1.8–13.1], P = 0.001 for C‐reactive protein, and from 16.2 [14.0–18.4] to 14.9 [11.5–17.8] mL/kg/min, P = 0.017, for VO2peak).ConclusionsThese data validate IL‐1 as an active and dynamic modulator of cardiac function and cardiorespiratory fitness in HF.
Chiral Organocatalysts in Enantioselective CO2 Utilization Reactions
Authors: Mori Taiki , Nishiyori Ryuichi , Sumida Sao , Furuya Yasuaki , Shirakawa Seiji 
Published: July 2023

AbstractThe development of efficient CO2 utilization reactions has gained a significant amount of attention in recent years. Although transformations of CO2 to produce basic chemicals have been extensively investigated, the development of catalytic enantioselective CO2 utilization reactions for the preparation of fine chemicals remains limited at this stage. Several excellent methods for catalytic enantioselective CO2 utilization using chiral metal complex catalysts have been reported. Many researchers have also focused on developing organocatalyzed approaches to enantioselective CO2 utilization, and several excellent examples have appeared in recent years. Herein, recent advances in catalytic enantioselective CO2 utilization reactions using chiral organocatalysts are reviewed to provide a forecast for organocatalyzed enantioselective CO2 utilization research.
Experimental study of precast concrete walls with replaceable corner components
Authors: Cheng Xiaowei , Dong Xiaowei , Li Yi , Lu Xinzheng , Du Xiuli 
Published: July 2023

AbstractTo improve the seismic resiliency of precast concrete (PC) wall, a type of emulative PC wall with replaceable corner components (RCCs) was developed in this study. The damage of the PC wall was deliberately concentrated in the RCCs, which can be replaced after an earthquake. Four large‐aspect‐ratio specimens (including three PC walls with different tensile strength RCCs, and one monolithic cast‐in‐place reinforced concrete (RC) wall) were tested to investigate the seismic behavior of the PC wall, the replaceability of the RCCs, and comparability of the PC wall with the RC wall. Although flexural failure occurred for the three PC walls, the locations of damage were different. For PC walls with low and moderate tensile strength RCCs, the damage was successfully concentrated in RCCs, while for PC wall with high tensile strength RCCs, the damage was expanded from RCCs to the non‐replaced part of the PC wall. When RCCs had approximately identical tensile strength to the boundary element of RC wall, the performance of the PC wall emulated that of the RC wall. The ultimate drift ratio of the PC walls ranged from 1.7% to 2.2% which is lower than that of 2.7% for the RC wall. The PC wall, before and after replacing RCCs, exhibited approximately identical lateral load, while slight lower initial stiffness. The vertical displacement profiles of wall bottom section were almost linear, and the yielding and peak strength of the PC walls could be reasonably estimated by assuming the wall bottom section remain plane after deformation.
Satisfying strict deadlines for cellular Internet of Things through hybrid multiple access
Authors: Gamgam Onur Berkay , Karasan Ezhan 
Published: July 2023

AbstractLatency‐constrained aspects of cellular Internet of Things (IoT) applications rely on Ultra‐Reliable and Low Latency Communications (URLLC), which highlight research on satisfying strict deadlines. In this study, we address the problem of latency‐constrained communications with strict deadlines under average power constraint using Hybrid Multiple Access (MA), which consists of both Orthogonal MA (OMA) and power domain Non‐Orthogonal MA (NOMA) as transmission scheme options. We aim to maximize the timely throughput, which represents the average number of successfully transmitted packets before deadline expiration, where expired packets are dropped from the buffer. We use Lyapunov stochastic optimization methods to develop a dynamic power assignment algorithm for minimizing the packet drop rate while satisfying time average power constraints. Moreover, we propose a flexible packet dropping mechanism called Early Packet Dropping (EPD) to detect likely to become expired packets and drop them immediately. Numerical results show that Hybrid MA improves the timely throughput compared to conventional OMA by up to and on average by more than . With EPD, these timely throughput gains improve to and , respectively.
Comparison of micronutrients in adult enteral formulas widely used in clinical practice
Authors: Yang Hong , Hou Ling , Sun Hong Mei , Ye Shu Hong 
Published: July 2023

AbstractIn recent decades, great progress in the area of enteral nutrition has provided a large variety and commercial availability of enteral formulas, usually produced by the nutrition divisions of several pharmaceutical or dairy manufacturers, with specific compositions for each type of disease or patient condition. Despite the widespread use of enteral formulas, both in hospitals and at home, studies performed on the micronutrient compositions of adult enteral formulas are few in China. The content of micronutrients in 31 commercially available adult enteral formulas in the Chinese market was compared with the Chinese dietary reference intakes (DRIs), the tolerable upper limits (UL), the limit requirements in Food Safety National Standards General Rules of Foods for Special Medical Purposes (GB 29922‐2013), and the European Society for Clinical Nutrition and Metabolism (ESPEN) micronutrient guideline (2022). The micronutrient content was calculated by multiplying the value provided on the nutrition label for each product by the daily energy dose of 1500 and 1800 Kcal/day. The research results showed that most adult enteral formulas were generally suitable for patients on long‐term total enteral nutrition support in the Chinese market, and foods for special medical purpose (FSMP) formulas were more suitable than enteral nutrition preparation (ENP) formulas. However, the vitamin D, vitamin K, and iron content in these formulas should be appropriately increased to the limit recommended by the ESPEN micronutrient guideline. The results could provide a basis for manufacturers to research and develop more suitable enteral formulas and help clinical dietitians administer more effective enteral nutrition support for patients on long‐term total enteral nutrition in clinical practice, especially individualized treatment.
An interdisciplinary approach to Late/Final Neolithic coastal gallery graves in Brittany, Western France: The 3D structure, origin of stone material, and paleoenvironmental setting of the Kernic and Lerret monuments
Authors: Gorczyńska Aneta , Le Gall Bernard , Stéphan Pierre , Pailler Yvan 
Published: July 2023

AbstractThis article presents an interdisciplinary study of two Late/Final Neolithic gallery graves (Kernic and Lerret) located on the orthwestern coast of Brittany (Western France). These monuments show striking similarities in terms of architectural style and geographical position. This paper aims to provide a better understanding of the construction strategy of these monuments by (i) determining the origin of the megalithic blocks using comparative petro‐structural analyses of blocks and surrounding rocks, (ii) reconstructing the coastal environment from sediment core analyses and (iii) defining the significance of these monuments in the territories from an intervisibility analysis. The study reveals marked differences between the two monuments studied. The Lerret gallery grave was erected close to a unique source of stone material on the margins of a marshland zone. In contrast, the Kernic monument, erected on the edge of an estuary, seems to have been built using a deliberate diversification of stone extraction sites. An intervisibility analysis shows a dense network of visual interconnections between a number of megalithic tombs present in the study area, where the two monuments occupy very distinct sites. The social implications of stone selection and the geographical location of Late/Final Neolithic funerary monuments are also discussed in an enlarged regional context.
Complete pathological response after chemotherapy or immune checkpoint inhibitors in deficient MMR metastatic colorectal cancer: Results of a retrospective multicenter study
Authors: Marolleau Pauline , Tougeron David , Allignet Benoit , Cohen Romain , Sefrioui David , Gallet Blandine , Dumont Frédéric , Guimbaud Rosine , Alouani Emily , Passot Guillaume , Desolneux Grégoire , Ghiringhelli François , Marchal Frédéric , Mourthadhoi Farouk , Coriat Romain , Desgrippes Romain , Locher Christophe , Goujon Gaël , Des Guetz Gaëtan , Aparicio Thomas , Paubelle Etienne , Dupré Aurélien , de la Fouchardière Christelle 
Published: July 2023

AbstractAbout 5% of the patients with metastatic colorectal cancers (mCRC) present microsatellite instability (MSI)/deficient mismatch repair system (dMMR). While metastasectomy is known to improve overall and progression‐free survival in mCRC, specific results in selected patients with dMMR/MSI mCRC are lacking. Our study aimed to describe metastasectomy results, characterize histological response and evaluate pathological complete response (pCR) rate in patients with dMMR/MSI mCRC. We retrospectively reviewed data from all consecutive patients with dMMR/MSI mCRC who underwent surgical metastasectomy between January 2010 and June 2021 in 17 French centers. Primary outcome was to assess the pCR rate defined by tumor regression grade (TRG) 0. Secondary endpoints included relapse‐free survival (RFS) and overall survival (OS), and explored TRG as predictive factor for RFS and OS. Among the 88 patients operated, 109 metastasectomies were performed in 81 patients after neoadjuvant treatment [chemotherapy ± targeted therapy (CTT): 69, 85.2%; immunotherapy (ICI): 12, 14.8%], and pCR was achieved in 13 (16.1%) patients. Among the latter, pCR rate were 10.2% in the patients having received CTT (N = 7) and 50.0% in the patients treated with ICI (N = 6). Radiological response did not predict TRG. With a median follow‐up of 57.9 (IQR 34.2‐81.6) months, median RFS was 20.2 (15.4‐not reached) months, median OS was not reached. Major pathological responses (TRG0 + TRG1) were significantly associated with longer RFS (HR 0.12, 95% CI 0.03‐0.55; P = .006). The pCR rate of 16.1% achieved with neoadjuvant treatment in patients with dMMR/MSI mCRC is consistent with previously reported rates in pMMR/MSS mCRC. Immunotherapy showed better pCR rate than chemotherapy ± targeted therapy. Further prospective trials are needed to validate immunotherapy as neoadjuvant treatment in resectable/potentially resectable dMMR/MSI mCRC and identify predictive factors for pCR.