bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Pemberian Pupuk Organik Cair Hasil Fermentasi Buah Maja dan Pupuk Organik Cair NASA Terhadap Pertumbuhan Tanaman Tomat (Lycopersicum esculentum)
Authors: Kamilia Wardah , Laili Saimul , Tito Sama'iradat 
Published: September 2023

Tomato (Lycopersicum esculentum) is a multipurpose and multifunctional fruit vegetable that can be cultivated in lowland or highland land. One of the factors that greatly affect the yield of tomato plants is fertilization. Liquid organic fertilizer fermented maja fruit is a simple fertilizer extracted from maja fruit, liquid organic fertilizer fermented maja fruit can provide additional organic matter in the form of nutrients needed by plants. NASA liquid organic fertilizer is a liquid organic fertilizer which is an extraordinary invention in the world of agriculture and can provide nutrients to plants. This research was conducted in the garden of Jalan Joyo Suryo, Merjosari, Kec. Lowokwaru, Malang City in June â€“ August 2021. The results showed that the best in the study was the administration of NASA liquid organic fertilizer with a concentration of 20 ml due to the availability of macro and micro nutrients which were more complete and easily absorbed than the liquid organic fertilizer fermented by maja fruit. which also has lower effectiveness at 5ml concentration.
Keywords: Maja Fermentation liquid organic fertilizer, NASA liquid organic fertilizer, Tomato
ABSTRAK
Tomat (Lycopersicum esculentum) tergolong sayuran buah multiguna dan multifungsi yang dapat dibudidayakan di lahan dataran rendah ataupun lahan dataran tinggi. Salah satu faktor yang sangat mempengaruhi hasil tanaman tomat adalah pemupukan. Pupuk organik cair hasil fermentasi buah maja merupakan pupuk sederhana yang diekstraksi dari buah maja, pupuk organik cair hasil fermentasi buah maja dapat memberi tambahan bahan organik berupa unsur hara yang diperlukan tanaman. Pupuk organik cair NASA adalah pupuk organik cair yang merupakan penemuan yang luar biasa dalam dunia pertanian serta dapat memenuhi nutrisi pada tanaman. Penelitian ini dilaksanakan di kebun Jalan Joyo Suryo, Merjosari, Kec. Lowokwaru, Kota Malang pada bulan Juni – Agustus 2021. Hasil penelitian menunjukkan yang terbaik dalam penelitian yaitu pada pemberian pupuk organik cair NASA konsentrasi 20ml karena ketersediaan unsur hara makro dan mikro yang lebih lengkap dan mudah terserap dengan baik dibanding pupuk organik cair hasil fermentasi buah maja yang juga memiliki efektivitas lebih rendah dengan konsentrasi 5ml.
Kata kunci: POC Maja, POC NASA, Tomat
La literatura áurea en el entorno digital (2017-2020): balance, metodologías y diagnósticos
Authors: Martos Pérez María D. 
Published: September 2023

El objetivo de este art.culo es ofrecer una visi.n panor.mica de las principales líneas de investigaci.n sobre humanidades digitales aplicadas a los estudios del Siglo de Oro en el trienio que va de 2018 a 2020.
Perspectivas coloniales de la medicina novohispana en el "Tratado breve de medicina de Agustín Farfán (1592)"
Authors: Zinni Mariana C. 
Published: September 2023

El Tratado breve de medicina y de todas las enfermedades que a cada paso se ofrecen (1592), publicado por Agustín de Farfán, posee un fuerte anclaje colonial en sus supuestos epistemológicos. El compendio abreva en la experiencia médica prehispánica, y está dirigido a aquellos que viven en ámbitos rurales o alejados de los centros urbanos y de la atención médica. Farfán somete la medicina a un doble proceso de hibridación y mestizaje que deriva en una profunda transculturación del saber médico, una fusión del arte de curar con elementos nativos y una política colonial del cuerpo y el discurso médico anclado en una «hibridez controlada».
HERBIS ET VERBIS. Plantas medicinales chilenas en la Literatura de los siglos XVI y XVII
Authors: Sartori Matteo 
Published: September 2023

El propósito general de la investigación es estudiar las dinámicas históricas de los saberes acerca de las hierbas sanadoras chilenas a través de las obras literarias de los siglos +,& y +,&&, desde la perspectiva de la historia del conocimiento y como procesos de hibridismo cultural. El análisis permitirá, además, aclarar, por un lado, que las plantas dibujadas por el jesuita Alonso de Ovalle (1646) son las que gozaban de una mayor relevancia social. Por otro lado, se mostrará la importancia de estudiar las fuentes cientícas junto a las literarias para considerar también la ignorancia como un aspecto clave en la formación y circulación del conocimiento.
Continuous bioreactor production of polyhydroxyalkanoates in Haloferax mediterranei
Authors: Parroquin-Gonzalez Mariana , Winterburn James 
Published: September 2023

In this work, the viability of continuous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) production with controlled composition in Haloferax mediterranei when fed volatile fatty acids is demonstrated. Continuous fermentations showed to greatly outperform batch fermentations with continuous feeding. Operating the bioreactor continuously allowed for PHBV productivity normalised by cell density to increase from 0.29 to 0.38 mg L−1 h−1, in previous continuously fed-fed batch fermentations, to 0.87 and 1.43 mg L−1 h−1 in a continuous mode of operation for 0.1 and 0.25 M carbon concentrations in the media respectively. Continuous bioreactor experiments were carried out for 100 h, maintaining control over the copolymer composition at around 30 mol% 3-hydroxyvalerate 3HV. This work presents the first continuous production of PHBV in Haloferax mediterranei which continuously delivers polymer at a higher productivity, compared to fed-batch modes of operation. Operating bioreactors continuously whilst maintaining control over copolymer composition brings new processing opportunities for increasing biopolymer production capacity, a crucial step towards the wider industrialisation of polyhydroxyalkanoates (PHAs).
Cancer stem cells are prevalent in the basal-like 2 and mesenchymal triple-negative breast cancer subtypes in vitro
Authors: Olsson Maxim , Larsson Peter , Johansson Junko , Sah Vasu R. , Parris Toshima Z. 
Published: September 2023

Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with the most unfavorable clinical outcomes, in part due to tumor heterogeneity, treatment resistance, and tumor relapse. The TNBC subtypes [basal-like 1 (BL1), basal-like 2 (BL2), mesenchymal (M), and luminal androgen receptor (LAR)] are biologically and clinically distinct entities that respond differently to local and systemic therapies. Therefore, we need to have a better understanding of cancer stemness relating to drug-resistant populations in the TNBC subtypes.Methods: Breast cancer stem cell (BCSC) distribution was investigated using an integrated flow cytometry approach with the ALDEFLUOR™ assay (ALDH) and CD24/CD44 antibodies. In total, 27 commercially available cell lines derived from normal and malignant mammary tissue were characterized into differentiated tumor cells and/or BCSC subpopulations (ALDH−CD44+CD24-/low enriched mesenchymal-like BCSCs, ALDH+non-CD44+CD24−/low enriched epithelial-like BCSCs, and highly purified ALDH+CD44+CD24−/low BCSCs).Results: BCSCs were not only enriched in estrogen receptor (ER) negative (mean, 49.6% versus 6.9% in ER+) and TNBC cell lines (51.3% versus 2.1% in Luminal A), but certain BCSC subpopulations (e.g., enriched mesenchymal-like BCSCs) were also significantly more common in the M (64.0% versus 6.2% in BL1; 64.0% versus 0% in LAR) and BL2 (77.4% versus 6.2% in BL1; 77.4% versus 0% in LAR; 77.4% versus 10.4% in TNBC UNS) TNBC subtypes. In contrast, ALDH status alone was not indicative of ER status or BC subtype.Conclusion: Taken together, these findings demonstrate the enrichment of potentially treatment-resistant BCSC subpopulations in the M and BL2 triple-negative breast cancer subtypes.
Establishment of hypertension risk nomograms based on physical fitness parameters for men and women: a cross-sectional study
Authors: Xu Yining , Shi Zhiyong , Sun Dong , Munivrana Goran , Liang Minjun , István Bíró , Radak Zsolt , Baker Julien S. , Gu Yaodong 
Published: September 2023

ObjectiveThis study aims to establish hypertension risk nomograms for Chinese male and female adults, respectively.MethodA series of questionnaire surveys, physical assessments, and biochemical indicator tests were performed on 18,367 adult participants in China. The optimization of variable selection was conducted by running cyclic coordinate descent with 10-fold cross-validation through the least absolute shrinkage and selection operator (LASSO) regression. The nomograms were built by including the predictors selected through multivariable logistic regression. Calibration plots, receiver operating characteristic curves (ROC), decision curve analysis (DCA), clinical impact curves (CIC), and net reduction curve plots (NRC) were used to validate the models.ResultsOut of a total of 18 variables, 5 predictors—namely age, body mass index, waistline, hipline, and resting heart rate—were identified for the hypertension risk predictive model for men with an area under the ROC of 0.693 in the training set and 0.707 in the validation set. Seven predictors—namely age, body mass index, body weight, cardiovascular disease history, waistline, resting heart rate, and daily activity level—were identified for the hypertension risk predictive model for women with an area under the ROC of 0.720 in the training set and 0.748 in the validation set. The nomograms for both men and women were externally well-validated.ConclusionGender differences may induce heterogeneity in hypertension risk prediction between men and women. Besides basic demographic and anthropometric parameters, information related to the functional status of the cardiovascular system and physical activity appears to be necessary.
Serial echocardiographic evaluation of COVID-19 patients without prior history of structural heart disease: a 1-year follow-up CRACoV-HHS study
Authors: Olszanecka Agnieszka , Wojciechowska Wiktoria , Bednarek Agnieszka , Kusak Piotr , Wizner Barbara , Terlecki Michał , Stolarz-Skrzypek Katarzyna , Klocek Marek , Drożdż Tomasz , Sładek Krzysztof , Bociąga-Jasik Monika , Garlicki Aleksander , Rewiuk Krzysztof , Matyja Andrzej , Małecki Maciej , Sydor Wojciech , Krzanowski Marcin , Grodzicki Tomasz , Rajzer Marek 
Published: September 2023

BackgroundIt is a well-known fact that COVID-19 affects the cardiovascular system by exacerbating heart failure in patients with preexisting conditions. However, there is a poor insight into the cardiovascular involvement and sequelae in patients without preexisting conditions. The aim of the study is to analyse the influence of COVID-19 on cardiac performance in patients without prior history of structural heart disease. The study is part of the CRACoV project, which includes a prospective design and a 12-month follow-up period.Material and methodsThe study included 229 patients hospitalised with a diagnosis of COVID-19 (median age of 59 years, 81 were women). A standard clinical assessment and laboratory tests were performed in all participants. An extended echocardiographic image acquisition was performed at baseline and at a 3-, 6-, and 12-month follow-up. All analyses were performed off-line. A series of echocardiographic parameters was compared using repeated measures or Friedman analysis of variance.ResultsIn all subjects, the left ventricular (LV) ejection fraction at baseline was preserved [63.0%; Q1:Q3 (60.0–66.0)]. Elevated levels of high-sensitivity cardiac troponin T were detected in 21.3% of the patients, and elevated NT-proBNP levels were detected in 55.8%. At the 1-year follow-up, no significant changes were observed in the LV diameter and volume (LV 48.0 ± 5.2 vs. 47.8 ± 4.8 mm, p = 0.08), while a significant improvement of the parameters in the biventricular strain was observed (LV −19.1 ± 3.3% vs. −19.7 ± 2.5%, p = 0.01, and right ventricular −19.9 ± 4.5% vs. −23.2 ± 4.9%, p = 0.002). In addition, a decrease in the LV wall thickness was also observed (interventricular septum 10.4 ± 1.6 vs. 9.7 ± 2.0 mm, p &lt; 0.001; LV posterior wall 9.8 ± 1.4 vs. 9.1 ± 1.5 mm, p &lt; 0.001).ConclusionsIn an acute phase of COVID-19, the elevation of cardiac biomarkers in patients with normal left ventricular ejection fraction is a frequent occurrence; however, it does not translate into clinically significant cardiac dysfunction after 1 year. The serial echocardiographic evaluations conducted in patients without preexisting structural heart disease demonstrate an overall trend towards an improved cardiac function and a reduced myocardial thickening at 1-year follow-up. This suggests that the acute cardiac consequences of COVID-19 are associated with systemic inflammation and haemodynamic stress in patients without preexisting conditions.
Emerging pharmaceutical contaminants in key aquatic environments of the Philippines
Authors: Mariano Shyrill Mae F. , Angeles Luisa F. , Aga Diana S. , Villanoy Cesar L. , Jaraula Caroline Marie B. 
Published: September 2023

Pharmaceuticals in natural waters are considered emerging pollutants due to their low concentrations and the negative effects they pose to the environment. Common sources of such pollutants include untreated wastewater from hospitals, residential, industrial, and agricultural sources. Many wastewater treatment methods only remove a subset of all pharmaceuticals from the wastewater; remaining pharmaceuticals are discharged into natural waters, and ultimately drain into coastal areas. Regions without proper wastewater treatment are especially susceptible to such contamination. This study deals with the distribution, sources, and seasonal variability of pharmaceuticals in key aquatic systems in the Philippines. Two watershed continuums (Davao Gulf, Davao City; Macajalar Bay, Cagayan de Oro City); two tourist areas (Boracay Island, Aklan; Mabini, Batangas); and one pristine atoll (Tubbataha Reefs, Palawan)—all with varied prevailing human population pressures—were studied. Samples of hospital wastewater as well as groundwater, surface and bottom water samples from rivers and coastal seas collected during dry and wet seasons were analyzed using solid-phase extraction and liquid chromatography-tandem mass spectrometry. Thirty-four target pharmaceutical residues and antibiotics were extracted and quantified. Acetaminophen was detected at concentrations of up to 289.17 ppb in freshwater samples, and at concentrations of up to 253.39 ppb in seawater samples. Ubiquitous to all the sites was caffeine, reaching 1848.57 ppb. Sulfamethazine, a commonly used veterinary antibiotic, was detected at 764.91 ppb in a river site in Cagayan de Oro. Untreated hospital wastewater contained metformin, iopamidol, sulfamethoxazole, acetylsulfamethoxazole, ciprofloxacin, and azithromycin, but these pharmaceuticals were not detected in other river and coastal waters. Samples collected during the dry season exhibited higher concentrations than those from the wet season, which appears to be related to increase in transient populations from tourism activities as well as dilution. The presence of pharmaceutical residues and antibiotics in these areas and the potential impact on the environment indicate the need for stricter wastewater management measures, particularly in communities located near water bodies. As the results of this study show, such measures might be most beneficial and effective if imposed during dry season and in areas open to tourism.
Anticipated correlation between lean body mass to visceral fat mass ratio and insulin resistance: NHANES 2011-2018
Authors: Shao Ya , Li Longti , Zhong Huiqin , Wang Xiaojun , Hua Yu , Zhou Xu 
Published: September 2023

ObjectiveThe relationship between body composition and insulin resistance (IR) is controversial. This study aimed to thoroughly examine the correlation between adipose tissue, lean body mass, and IR as evaluated by the Homeostatic Model Assessment (HOMA-IR).MethodsIn this cross-sectional study, we utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2018. Our study included 4981 subjects, and we employed multiple linear regression, smoothed curve fitting, threshold, and saturation effect analysis to investigate the relationship between lean body mass, visceral fat mass, and IR. Also, we used the lean body mass to visceral fat ratio (Log LM/VFM) as a proxy variable to analyze its association with IR alone.ResultsThe study discovered a negative link between lean body mass and IR, but the visceral fat mass was positively correlated after correcting for covariates. A negative correlation was observed when the alternative variable Log LM/VFM was analyzed separately for its association with IR. This association was present regardless of whether the exposure variables were analyzed as continuous or categorical. The data analysis revealed a nonlinear relationship between Log LM/VFM and IR, as evidenced by the generalized additive model. In addition, a threshold effect with a critical value of 1.80 and a saturation effect with a critical point of 2.5 were also observed. Further subgroup analysis for sex, age, BMI, active levels, hypertension, and diabetes showed considerable robustness between the relationship of Log LM/VFM and IR.ConclusionMaintaining a proper ratio of lean body mass and visceral fat is beneficial for decreasing IR.
Assessment of common risk factors of diabetes and chronic kidney disease: a Mendelian randomization study
Authors: Zhao Shuwu , Li Yiming , Su Chen 
Published: September 2023

BackgroundThe increasing prevalence of diabetes and its significant impact on mortality and morbidity rates worldwide has led to a growing interest in understanding its common risk factors, particularly in relation to chronic kidney disease (CKD). This research article aims to investigate the shared risk factors between type 1 diabetes (T1D), type 2 diabetes (T2D), and CKD using a Mendelian randomization (MR) design.MethodsThe study utilized genome-wide association study (GWAS) datasets for T1D, T2D, and CKD from the FinnGen research project. GWAS summary statistics datasets for 118 exposure traits were obtained from the IEU OpenGWAS database. MR analyses were conducted to examine the causal relationships between exposure traits and each of the three outcomes. Multiple methods, including inverse-variance weighted, weighted median, and MR-Egger, were employed for the MR studies.ResultsPhenome-wide MR analyses revealed that eosinophil percentage exhibited a significant and suggestive causal association with T1D and CKD, respectively, suggesting its potential as a shared risk factor for T1D and CKD. For T2D, 34 traits demonstrated significant associations. Among these 34 traits, 14 were also significantly associated with CKD, indicating the presence of common risk factors between T2D and CKD, primarily related to obesity, height, blood lipids and sex hormone binding globulin, blood pressure, and walking pace.ConclusionThis research has uncovered the eosinophil percentage as a potential common risk factor for both T1D and CKD, while also identifying several traits, such as obesity and blood lipids, as shared risk factors for T2D and CKD. This study contributes to the understanding of the common risk factors between diabetes and CKD, emphasizing the need for targeted interventions to reduce the risk of these diseases.
RETRACTED: Optimizing electric vehicle charging schedules and energy management in smart grids using an integrated GA-GRU-RL approach
Authors: Zhao Xinhui , Liang Guojun 
Published: September 2023

Introduction: Smart grid technology is a crucial direction for the future development of power systems, with electric vehicles, especially new energy vehicles, serving as important carriers for smart grids. However, the main challenge faced by smart grids is the efficient scheduling of electric vehicle charging and effective energy management within the grid.Methods: To address this issue, we propose a novel approach for intelligent grid electric vehicle charging scheduling and energy management, integrating three powerful technologies: Genetic Algorithm (GA), Gated Recurrent Unit (GRU) neural network, and Reinforcement Learning (RL) algorithm. This integrated approach enables global search, sequence prediction, and intelligent decision-making to optimize electric vehicle charging scheduling and energy management. Firstly, the Genetic Algorithm optimizes electric vehicle charging demands while minimizing peak grid loads. Secondly, the GRU model accurately predicts electric vehicle charging demands and grid load conditions, facilitating the optimization of electric vehicle charging schedules. Lastly, the Reinforcement Learning algorithm focuses on energy management, aiming to minimize grid energy costs while meeting electric vehicle charging demands.Results and discussion: Experimental results demonstrate that the method achieves prediction accuracy and recall rates of 97.56% and 95.17%, respectively, with parameters (M) and triggers (G) at 210.04 M and 115.65G, significantly outperforming traditional models. The approach significantly reduces peak grid loads and energy costs while ensuring the fulfilment of electric vehicle charging demands and promoting the adoption of green energy in smart city environments.
Community-driven research and capacity building to address environmental justice concerns with industrial air pollution in Curtis Bay, South Baltimore
Authors: Aubourg Matthew A. , Sawtell Greg , Deanes Lauren , Fabricant Nicole , Thomas Meleny , Spicer Kristoffer , Wagar Caila , Campbell Shashawnda , Ulman Abigail , Heaney Christopher D. 
Published: September 2023

IntroductionCurtis Bay (CB) is an environmental justice (EJ) community in South Baltimore. With a high concentration of industrial polluters and compounding non-chemical stressors, CB has experienced socioeconomic, quality of life, and health burdens for over 100 years. Today, these polluters include the open-air CSX Coal Terminal, waste-to-energy incinerators, and heavy diesel traffic through residential areas. The Community of Curtis Bay Association, Free Your Voice, and South Baltimore Community Land Trust are local organizations enacting a vision for equitable, healthy, and community-led development without industrial encroachment. In response to community-identified EJ concerns and an explosion at the CSX Coal Terminal, CB community groups partnered with academic researchers to develop a community-driven hyperlocal air monitoring and capacity building approach. This paper describes this approach to characterizing hyperlocal air quality in CB, building bridges between community residents and regulatory agencies, and nurturing a cohesive and effective community-academic partnership toward EJ.MethodsUsing hyperlocal air monitoring, we are collecting real-time air pollution (particulate matter, black carbon, and ground-level gas species) and meteorological data from 15 low-cost sensors in residential and industrial areas of CB. We also use trail cameras to record activities at the CSX Coal Terminal. We merge air pollution and industrial activity data to evaluate the following: overall air quality in CB, multi-air pollutant profiles of elevated events, spatiotemporal changes in air quality in the community, patterns of industrial activity, and potential correlations between air quality and observed industrial activity. Members of our partnership also lead a high school course educating students about the history and ongoing efforts of the EJ movement in their community. Students in this course learn how to employ qualitative and quantitative data collection and analysis methods to bring scientific support to community EJ concerns.Results and DiscussionOur hyperlocal air monitoring network and community-academic partnership are continuing to evolve and have already demonstrated the ability to respond to community-identified EJ issues with real-time data while developing future EJ leaders. Our reflections can assist other community and academic groups in developing strong and fruitful partnerships to address similar EJ issues.