bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chained Packets for Multimedia Random Access in Next Generation Internet of Things
Authors: Woo Tai-Kuo , Fu Chen-Hua 
Published: March 2023

Abstract
Multimedia IoT has become a new megatrend foreseen to impact many application areas. Random access is the major bottleneck for achieving the goal of being real-time. In this paper, we propose chained packet based multichannel architecture for random access, where the selection of a time slot/channel pair is based on Finite Projective Plane and random numbers and the packets of transmitting nodes are formed as a chain through logical XOR operations with adjacent packets. To retrieve packets in collision time slots, the packets involved in a collision time slot are extracted one by one using the neighboring singleton packet. Retrieving collision time slots not only increases the throughput but also improves the quality of service. However, the collision time slots that form a closed loop in the chained packet transmission cannot be resolved. We analyze the throughput of the chained packet approach in comparison to the plain packet approach and perform simulation runs for verification. The chained packet transmission is well suited for moderate to heavy load and the number of channels is rather limited.The results of analysis and simulation runs show that the improvement in throughput is up to 50 percent using chained packet transmission.
Individual- and Neighborhood-Level Characteristics of Lung Cancer Screening Participants Undergoing Telemedicine Shared Decision Making
Authors: Shusted Christine , Juon Hee-Soon , Ruane Brooke , Till Brian , Zeigler-Johnson Charnita , McIntire Russell K. , Grenda Tyler , Okusanya Olugbenga , Evans Nathaniel R. , Kane Gregory C. , Barta Julie A. 
Published: March 2023

Abstract
Background: Although lung cancer screening (LCS) for high-risk individuals reduces lung cancer mortality in clinical trial settings, many questions remain about how to implement high-quality LCS in real-world programs. With the increasing use of telemedicine in healthcare, studies examining this approach in the context of LCS are urgently needed. We aimed to identify sociodemographic and other factors associated with screening completion among individuals undergoing telemedicine LCS.
Methods: This retrospective study examined patients who completed Shared Decision Making (SDM) via telemedicine between May 4, 2020 – March 18, 2021 in a centralized LCS program. Individuals were categorized into Complete Screening vs. Incomplete Screening subgroups based on the status of subsequent LDCT completion. A multi-level, multivariate model was constructed to identify factors associated with incomplete screening.
Results: Among individuals undergoing telemedicine SDM during the study period, 20.6% did not complete a LDCT scan. Bivariate analysis demonstrated that Black/African-American race, Medicaid insurance status, and new patient type were associated with greater odds of incomplete screening. On multi-level, multivariate analysis, individuals who were new patients undergoing baseline LDCT or resided in a census tract with a high level of socioeconomic deprivation had significantly higher odds of incomplete screening. Individuals with a greater level of education experienced lower odds of incomplete screening.
Conclusions: Among high-risk individuals undergoing telemedicine SDM for LCS, predictors of incomplete screening included low education, high neighborhood-level deprivation, and new patient type. Future research should focus on testing implementation strategies to improve LDCT completion rates while leveraging telemedicine for high-quality LCS.
ROCK inhibitor inhibits the growth and migration of oral squamous cell carcinoma via up-regulated autophagy by suppressing AKT/mTOR pathway
Authors: Wen Jie , Ma Li , Zu Tingjian , Wang Na , Zhang Tianqi , Liang Jin , Sun Yunhan , Zhang Yulei , Liu Rui , Zhang Shizhou , Wu Yihua 
Published: March 2023

Abstract
Background
Rho-associated protein kinase(ROCK) plays important roles in cell proliferation and migration, depending on cancer types. ROCK inhibitor Y-27632 was referred as a potential immunotherapy strategy for cancer treatment. Oral squamous cell carcinoma (OSCC) remains one of the most aggressive oral carcinoma types. Y-27632 was shown to block the growth, migration and invasion of Cal27 cells, but no detailed studies of underlying mechanisms have been reported.
Methods
In this study we explored the effect of Y27632 on OSCC (Cal27, SCC4, SCC9) by comparing with and without Y27632 treatment in vitro and in vivo. And further investigations were done to reveal the expression of AKT/mTOR pathway by Biochemical assays, additionally AKT activator (SC79) or mTOR activator (3BDO) was utilized to evaluate the roles of AKT/mTOR pathway in Y27632-induced tumor suppression.
Results
Our data showed Y-27632 had a strong inhibitory activity against OSCC (Cal27, SCC4, SCC9). In vivo assays confirmed that Y-27632 suppressed OSCC growth by reducing cell proliferation, and importantly Y-27632 did not have any evident toxicity on normal tissues. Biochemical assays demonstrated that Y-27632 inactivated the AKT/mTOR pathway, and treatment with SC79 or 3BDO, respectively AKT and mTOR activator rescued the cell growth and migration inhibition elicited by Y-27632. Further investigations revealed that Y-27632 could enhance cell autophagy by suppressing AKT/mTOR pathway.
Conclusions
Our study demonstrated that Y-27632 significantly suppressed the AKT/mTOR pathway to promote cell autophagy to inhibit OSCC growth, providing a potential therapeutic drug for OSCC treatment in the future.
Proteomic Characterization of Acute Kidney Injury in Patients Hospitalized with SARS-CoV2 Infection
Authors: Nadkarni Girish , Paranjpe Ishan , Jayaraman Pushkala , Su Chen-Yang , Zhou Sirui , Chen Steven , Valle Diane Del , Thompson Ryan , Kenigsberg Ephraim , Zhao Shan , Jaladanki Suraj , Chaudhary Kumardeep , Ascolillo Steven , Vaid Akhil , Gonzalez-Kozlova Edgar , Kumar Arvind , Paranjpe Manish , O'Hagan Ross , Kamat Samir , Gulamali Faris , Kauffman Justin , Xie Hui , Harris Joceyln , Patel Manishkumar , Argueta Kimberly , Batchelor Craig , Nie Kai , Dellepiane Sergio , Scott Leisha , Levin Matthew , He John , Suárez-Fariñas Mayte , Coca Steven , Chan Lili , Azeloglu Evren , Schadt Eric , Beckmann Noam , Gnjatic Sacha , Merad Miriam , Kim-Schulze Seunghee , Richards J. Brent , Glicksberg Benjamin , Charney Alexander 
Published: March 2023

Abstract
Background
Acute kidney injury (AKI) is a known complication of COVID-19 and is associated with an increased risk of in-hospital mortality. Unbiased proteomics using biological specimens can lead to improved risk stratification and discover pathophysiological mechanisms.
Methods
Using measurements of ~4000 plasma proteins in two cohorts of patients hospitalized with COVID-19, we discovered and validated markers of COVID-associated AKI (stage 2 or 3) and long-term kidney dysfunction. In the discovery cohort (N= 437), we identified 413 higher plasma abundances of protein targets and 40 lower plasma abundances of protein targets associated with COVID-AKI (adjusted p <0.05). Of these, 62 proteins were validated in an external cohort (p <0.05, N =261).
Results
We demonstrate that COVID-AKI is associated with increased markers of tubular injury (NGAL) and myocardial injury. Using estimated glomerular filtration (eGFR) measurements taken after discharge, we also find that 25 of the 62 AKI-associated proteins are significantly associated with decreased post-discharge eGFR (adjusted p <0.05). Proteins most strongly associated with decreased post-discharge eGFR included desmocollin-2, trefoil factor 3, transmembrane emp24 domain-containing protein 10, and cystatin-Cindicating tubular dysfunction and injury.
Conclusions
Using clinical and proteomic data, our results suggest that while both acute and long-term COVID-associated kidney dysfunction are associated with markers of tubular dysfunction, AKI is driven by a largely multifactorial process involving hemodynamic instability and myocardial damage.
Anharmonic electron-phonon coupling in polymorphous perovskites
Authors: Zacharias Marios , Volonakis George , Giustino Feliciano , Even Jacky 
Published: March 2023

Abstract
Anharmonicity and disorder are ubiquitous in the physics of perovskites and give rise to a variety of unique phenomena observed in scattering and spectroscopy experiments with profound consequences for device applications. Several of these phenomena still lack interpretation from a first-principles perspective. Recently, the concept of polymorphism has been introduced in calculations of perovskite compounds, yielding substantial improvements in describing their electronic and structural properties. However, hitherto no approach is available to account for anharmonicity and polymorphism in the phonon dynamics and electron-phonon couplings. Here, we develop a unified framework for the treatment of both relying on the special displacement method. Combining the self-consistent phonon theory of Hooton and the Allen-Heine theory of electron-phonon renormalized band structures, we demonstrate our approach for temperature-dependent band gaps of oxide and halide cubic perovskites, obtaining unprecedented agreement with experiments. We also uncover that polymorphism in halide perovskites induces
phonon bunching and overdamping that lead to vibrational dynamics far from the ideal phonon picture, consistent with neutron scattering measurements. Moreover, our results suggest that accurate band gap predictions require corrections arising from polymorphism, spin-orbit coupling, hybrid functionals, and electron-phonon coupling. The present method provides the basis for investigating electron-phonon couplings in strongly anharmonic materials.
Tropical sources dominated methane changes of the last glacial maximum and deglaciation
Authors: Riddell-Young Ben , Rosen Julia , Brook Edward , Buizert Christo , Martin Kaden , Lee James , Edwards Jon , Mühl Michaela , Schmitt Jochen , Fischer Hubertus , Blunier Thomas 
Published: March 2023

Abstract
Constraining the causes of past atmospheric methane variability is important for understanding links between methane and climate. Abrupt methane changes during the last deglaciation have been intensely studied for this purpose, but the relative importance of high-latitude and tropical sources remains poorly constrained. The methane interpolar concentration difference (IPD) reflects past geographic source variability, but existing records suffered from subtle but significant methane production during analysis. Here, we report a new, ice-core derived IPD record covering the last glacial maximum and deglaciation, with substantially improved temporal resolution, chronology, and a critical correction for methane production in samples from Greenland. Using box-models to examine latitudinal source changes, we show that tropical sources dominated abrupt methane variability of the deglaciation, highlighting their sensitivity to abrupt climate change and rapidly shifting tropical rainfall patterns. Northern extratropical sources began increasing at ~16 kyr, likely through wetland expansion and/or permafrost degradation induced by high-latitude warming, and contributed at most 20 Tg yr-1 (40% of the total source increase) to the abrupt methane rise that coincided with rapid northern warming at the onset of the Bølling Allerød interval. These new deglacial methane budget constraints can be used to improve the understanding of climate-methane cycle feedbacks.
The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein degradation to promote cell proliferation and lymph node metastasis of urothelial bladder cancer
Authors: Yan Dong , He Qingqing , Pei Lu , Yang Meihua , Huang Lifang , Kong Jianqiu , He Wang , Liu Hao , Xu Shizhong , Qin Haide , Lin Tianxin , Huang Jian 
Published: March 2023

Abstract
Urothelial bladder cancer (UBC) is one of the most prevalent malignancies worldwide with striking tumor heterogeneity. Elucidating the molecular mechanism for the treatment of aggressive UBC is particularly relevant. Protein ubiquitination is critical constitution of post-translational modification (PTM) that mediates the degradation of target protein through proteasome. However, the roles of aberrant protein ubiquitination in UBC development and the underlying mechanism in driving tumor progression remain unclear. In this study, taking the advantage of CRISPR/Cas9 technology, we identified ubiquitin E3 ligase ANAPC11, a critical subunit of anaphase-promoting complex/cyclosome (APC/C), as a potential oncogenic molecule in UBC cells. Our clinical analysis showed that the elevated expression of ANAPC11 was significantly correlated with high T stage, positive lymph node metastasis and poor outcomes of UBC patients. By employing a series of in vitro experiments, we demonstrated that ANAPC11 boosted the proliferation and invasiveness of UBC cells, while knockout of ANAPC11 inhibited the growth and lymph node metastasis of UBC cells in vivo. By conducting immunoprecipitation coupled to mass spectrometry assays, we confirmed that ANAPC11 increased the ubiquitination level of Forkhead transcription factor FOXO3. As a result, the decrease of FOXO3 protein stability led to the down-regulation of the cell cycle regulator p21 and the abrogation of GULP1, a downstream effector of androgen receptor signaling. Taken together, ANAPC11 showed oncogenic functions in UBC by modulating the FOXO3 protein degradation. ANAPC11-FOXO3 regulatory axis might serve as a novel therapeutic target for UBC.
Indocyanine green combined with methylene blue versus methylene blue alone for sentinel lymph node biopsy in breast cancer: a retrospective study
Authors: Yang Qiuhui , Zhang Xiangjian 
Published: March 2023

Abstract
Background: Recent studies have shown that near-infrared (NIR) fluorescence imaging using Indocyanine green (ICG) may improve the efficiency of sentinel lymph node biopsy (SLNB). This study aimed to assess the effectiveness of the combination of ICG and methylene blue (MB) dye in patients undergoing SLNB. Results:Fluorescence imaging allowed 131 out of 136 patients in the ICG+MB group to see SLNs. ICG+MB group and MB group had detection rates of 98.5% and 91.5% (P=0.007, χ²=7.352), respectively, and the ICG+MB approach was able to produce improved recognition outcomes. What’s more, compared with the MB group, the ICG+MB group can identify more lymph nodes (3.1 to 2.6, P=0.000, t=4.447). Besides, in the ICG+MB group, ICG could identify more lymph nodes (LNs) than MB (3.1 vs 2.6, P=0.004, t=2.884).
Conclusion: ICG has high detection effectiveness for SLNs, and when paired with MB, the detection efficiency can be increased even further. Additionally, the ICG+MB tracing mode does not involve radioisotopes, which has a lot of promise for clinical use and can take the place of conventional standard detection methods.
Patients and Method: We evaluated ICG plus MB (ICG+MB) identification effectiveness with MB alone using retrospective analysis. From 2016 to 2020, we collected data on 300 eligible breast cancer patients who got SLNB treatment in our institution by ICG+MB injection or MB injection alone. By comparing the distribution of clinicopathological characteristics, the detection rate of sentinel lymph nodes (SLNs) and positive SLNs, as well as the total number of SLNs in the two groups, we were able to assess the imaging efficiency.
Research progress, trends, and updates on pollutants removal by Bi2WO6-based photocatalysts under visible light irradiation
Authors: Yang Jingjie , Zhong Shuang , Yang Jian , Cai Dandi , Wang Jue , Duan Jing 
Published: March 2023

Abstract
In recent years, bismuth tungstate (Bi2WO6) has been widely researched in the photocatalytic area due to its unique crystal structure and suitable bandgap. In this study, a comprehensive summary of Bi2WO6-based photocatalyst research from 2007 to 2022 was provided using bibliometric analysis. The study was conducted based on the Web of Science Core Collection Database and a dataset of 2064 publications retrieved. The bibliometix R-package and CiteSpace software were used for bibliometric analysis and science mapping. The network of the relationships among countries, journals, organizations, authors, and keywords related to investigated topic and subtopics were analyzed and discussed. Results showed that China has been playing an important role in this research area and also has a close cooperative relationship with other countries. Highly-cited emergent words indicated that improving the photocatalytic performance of Bi2WO6-based nanomaterials is the main research topic. In addition, the synergistic effects of photocatalysis and adsorption have also become a research hotspot for improving catalytic efficiency. The results will provide a reference for researchers for gaining a deeper understanding of Bi2WO6-based photocatalysts.
Influence of urbanisation on socioeconomic factors for harnessing the Demographic Dividend in Uganda: An exploratory analysis of the 2016 UDHS
Authors: Ssessanga Adrian , Galande Johnstone , Mbabazi Catherine 
Published: March 2023

Abstract
Background: The Uganda Vision 2040 underpins socioeconomic factors such as the country’s rapid population growth, a young population structure and a small proportion of the working population as major threats to Uganda’s aspiration of achieving socio-economic development. In order to position the country on a path for socioeconomic development, the National Population Policy emphasises the need for the population to adopt an urban character. This paper seeks to establish the influence of urbanisation on the socio-economic factors for harnessing the demographic dividend in Uganda exploring the urban/rural differentials, through an exploratory analysis of data from the 2016 Uganda Demographic and Health Survey.
Methods: Bivariate analysis and multivariate logistic regressions were used to determine the influence of urbanization on the explanatory variables which contribute to change in fertility. The significant variables (p<0.05) at the bivariate level were included in the two fit logistic regression models. The first model (model 1) shows the association between total children ever born and the explanatory factors in rural areas. The second model (model 2) adjusts for the enabling factors to the first model for women in urban areas.
Results: Women living in urban areas, with above secondary level education (OR 3.1: CI 2.5-3.8), whose age at first sex was within the legally accepted age range of 18-49 (OR 3.0: CI 2.4-3.5), and coming from wealthier households (OR 1.63: CI 1.2-2.2) have increased odds of producing less than 3 children modelled as most ideal for the attainment of the DD.
Conclusion: The influence of urbanisation towards harnessing the DD is especially through women’s education levels, increased household welfare and age at first sex.
Implementation framework for Income Generating Activities identified by Community Heath Volunteers (CHVs): a strategy to reduce CHVs attrition rate in Kilifi County Kenya
Authors: Riang’a Roselyter Monchari , Nyanja Njeri , Lusambili Adelaide , Mwangi Eunice Muthoni , Ehrlich Joshua R. , Clayde Paul , Mostert Cyprian , Ngugi Anthony 
Published: March 2023

Abstract
Background
Poorly designed project implementation strategy may not only reduce the morale and trust of the community but may also become a costly undertaking due to delayed project schedules and demotivation of project team. This study sought to identify viable modalities for implementing Income Generating Activities (IGAs) for Community Health Volunteers (CHV) in Kilifi County in Kenya as a strategy to improve their livelihoods, increase motivation and reduce attrition.
Methods:
An exploratory qualitative research study design was used, which consisted of Focus group discussions with CHVs involved in health promotion and data collection activities in a local setting. Further, key informant in-depth interviews were conducted among local stakeholder representatives and Ministry of Health officials. Data were recorded, transcribed and thematically analysed using MAXQDA 20.2 software. Data coding, analysis and presentation was guided by the Okumu’s (2003) Strategy Implementation framework.
Results:
A need for stable income was identified as the driving factor for CHVs seeking IGAs, as their health volunteer work is non-remunerative. Factors that that considered the local context such as government regulations, knowledge and experience, culture, and market viability informed their preferred IGA strategy. Individual savings through table-banking, seeking funding support through loans from government funding agencies (e.g., Uwezo Fund, Women Enterprise fund, Youth Fund), grants from corporate organizations, politicians, and other donors were proposed as viable options for raising capital for IGAs. Formal registration of IGAs with Government regulatory agencies, developing a guiding constitution, empowering CHVs with entrepreneurial and leadership skills, project and group diversity management, and connecting them to support agencies were the control measures proposed to support implementation and enhance sustainability of IGAs. Group owned and managed IGAs were preferred over individual IGAs.
Conclusion:
CHVs are in need of IGAs and proposed their own implementation strategies informed by local context. Agencies seeking to support CHVs livelihoods should therefore engage with and be guided by the input from CHVs and local stakeholders.
Interventions to prevent unintended pregnancies among adolescents: A rapid overview of systematic reviews
Authors: Mohamed Sahra , Chipeta Michael , Kamninga Tony , Nthakomwa Lomuthando , Chifungo Chimwemwe , Mzembe Themba , Vellemu Ruth , Chikwapulo Victor , Peterson Maame , Abdullahi Leyla , Musau Kelvin , Wazny Kerri , Zulu Eliya , Madise Nyovani 
Published: March 2023

Abstract
Risks associated with unintended pregnancy include unsafe abortions, poor maternal health-seeking behaviour, poor mental health and potentially, maternal and infant deaths. Adolescent girls faced with an unintended pregnancy are particularly vulnerable as they are at higher risk of eclampsia, premature onset of labour, and increased neonatal morbidity and mortality. Unintended pregnancy, with the right combination of interventions, can be avoided. Evidence-based decision-making and the need for a robust appraisal of the evidence have resulted in many systematic reviews. This review of systematic reviews focuses on adolescent pregnancy prevention and will seek to facilitate evidence-based decision-making. Two review authors independently extracted data and assessed the methodological quality of each review according to the AMSTAR 2 criteria. We identified three systematic reviews from low- and middle-income countries (LMICs) and high-income counties (HICs) and included all socioeconomic groups. We used vote counting and individual narrative review summaries to present the results. Overall, skill-building, peer-led and abstinence programmes were generally effective. Interventions focused on information only, counselling and interactive sessions provided mixed results. In contrast, exposure to parenting and delaying sexual debut interventions were generally ineffective. Adolescent pregnancy prevention interventions that deploy school-based primary prevention strategies, i.e., strategies that prevent unintended pregnancies in the first place, may effectively reduce teenage pregnancy rates, improve contraceptive use, attitudes and knowledge, and delay sexual debut. However, the included studies have methodological issues, and our ability to generalise the result is limited.