bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hierarchical recursive least squares parameter estimation methods for multiple‐input multiple‐output systems by using the auxiliary models
Authors: Xing Haoming , Ding Feng , Pan Feng , Yang Erfu 
Published: August 2023

SummaryMultiple‐input multiple‐output (MIMO) models are widely used in practical engineering. This article derives a new identification model of the MIMO system by decomposing the MIMO system into several multiple‐input single‐output subsystems. By means of the auxiliary model identification idea, an auxiliary model‐based recursive least squares (AM‐RLS) algorithm is derived for identifying the MIMO systems. In order to reduce the computational burden for identifying MIMO systems, this article presents a hierarchical identification model for the MIMO systems. By applying the hierarchical identification principle, an auxiliary model‐based hierarchical least squares (AM‐HLS) algorithm is proposed for improving the computational efficiency. The computational efficiency analysis indicates that the AM‐HLS algorithm is effective in reducing the calculation amount compared with the AM‐RLS algorithm. Moreover, this article analyzes the convergence of the AM‐HLS algorithm. The simulation example shows that the AM‐RLS and AM‐HLS algorithms studied in this article are effective.
Hyaluronan Metabolism in Urologic Cancers
Authors: Donelan William , Brisbane Wayne , O'Malley Padraic , Crispen Paul , Kusmartsev Sergei 
Published: August 2023

AbstractHyaluronan (HA) is one of the major components of the extracellular matrix in tumor tissue. Recent reports have made it clear that the balance of HA synthesis and degradation is critical for tumor progression. HA is synthesized on the cytoplasmic surface of the plasma membrane by hyaluronan synthases (HAS) and extruded into the extracellular space. Excessive HA production in cancer is associated with enhanced HA degradation in the tumor microenvironment, leading to the accumulation of HA fragments with small molecular weight. These perturbations in both HA synthesis and degradation may play important roles in tumor progression. Recently, it has become increasingly clear that small HA fragments can induce a variety of biological events, such as angiogenesis, cancer‐promoting inflammation, and tumor‐associated immune suppression. Progression of urologic malignancies, particularly of prostate and bladder cancers, as well as of certain types of kidney cancer show markedly perturbed metabolism of tumor‐associated HA. This review highlights the recent research findings regarding HA metabolism in tumor microenvironments with a special focus on urologic cancers. It also will discuss the potential implications of these findings for the development of novel therapeutic interventions for the treatment of prostate, bladder, and kidney cancers.
Telomerase mRNA Enhances Human Skin Engraftment for Wound Healing
Authors: Chang David F. , Court Karem A. , Holgate Rhonda , Davis Elizabeth A. , Bush Katie A. , Quick Andrew P. , Spiegel Aldona J. , Rahimi Maham , Cooke John P. , Godin Biana 
Published: August 2023

AbstractDeep skin wounds represent a serious condition and frequently require split‐thickness skin grafts (STSG) to heal. The application of autologous human‐skin‐cell‐suspension (hSCS) requires less donor skin than STSG without compromising the healing capacity. Impaired function and replicative ability of senescent cutaneous cells in the aging skin affects healing with autologous hSCS. Major determinants of senescence are telomere erosion and DNA damage. Human telomerase reverse transcriptase (hTERT) adds telomeric repeats to the DNA and can protect against DNA damage. Herein, hTERT mRNA lipid nanoparticles (LNP) are proposed and evaluated for enhancing cellular engraftment and proliferation of hSCS. Transfection with optimized hTERT mRNA LNP system enables delivery and expression of mRNA in vitro in keratinocytes, fibroblasts, and in hSCS prepared from donors’ skin. Telomerase activity in hSCS is significantly increased. hTERT mRNA LNP enhance the generation of a partial‐thickness human skin equivalent in the mouse model, increasing hSCS engraftment (Lamin) and proliferation (Ki67), while reducing cellular senescence (p21) and DNA damage (53BP1).
A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis
Authors: Kang Soo‐Yeon , Kimura Masaki , Shrestha Sunil , Lewis Phillip , Lee Sangjoon , Cai Yuqi , Joshi Pranav , Acharya Prabha , Liu Jiafeng , Yang Yong , Sanchez J. Guillermo , Ayyagari Sriramya , Alsberg Eben , Wells James M. , Takebe Takanori , Lee Moo‐Yeal 
Published: August 2023

AbstractHuman organoids have the potential to revolutionize in vitro disease modeling by providing multicellular architecture and function that are similar to those in vivo. This innovative and evolving technology, however, still suffers from assay throughput and reproducibility to enable high‐throughput screening (HTS) of compounds due to cumbersome organoid differentiation processes and difficulty in scale‐up and quality control. Using organoids for HTS is further challenged by the lack of easy‐to‐use fluidic systems that are compatible with relatively large organoids. Here, these challenges are overcome by engineering “microarray three‐dimensional (3D) bioprinting” technology and associated pillar and perfusion plates for human organoid culture and analysis. High‐precision, high‐throughput stem cell printing, and encapsulation techniques are demonstrated on a pillar plate, which is coupled with a complementary deep well plate and a perfusion well plate for static and dynamic organoid culture. Bioprinted cells and spheroids in hydrogels are differentiated into liver and intestine organoids for in situ functional assays. The pillar/perfusion plates are compatible with standard 384‐well plates and HTS equipment, and thus may be easily adopted in current drug discovery efforts.
Nanoporous Crystalline Materials for the Recognition and Applications of Nucleic Acids
Authors: Yu Long , Wang Yuhao , Sun Yuqing , Tang Yongling , Xiao Yuxiu , Wu Gaosong , Peng Shuang , Zhou Xiang 
Published: August 2023

AbstractNucleic acid plays a crucial role in countless biological processes. Hence, there is great interest in its detection and analysis in various fields from chemistry, biology, to medicine. Nanoporous crystalline materials exhibit enormous potential as an effective platform for nucleic acid recognition and application. These materials have highly ordered and uniform pore structures, as well as adjustable surface chemistry and pore size, making them good carriers for nucleic acid extraction, detection, and delivery. In this review, the latest developments in nanoporous crystalline materials, including metal organic frameworks (MOFs), covalent organic frameworks (COFs), and supramolecular organic frameworks (SOFs) for nucleic acid recognition and applications are discussed. Different strategies for functionalizing these materials are explored to specifically identify nucleic acid targets. Their applications in selective separation and detection of nucleic acids are highlighted. They can also be used as DNA/RNA sensors, gene delivery agents, host DNAzymes, and in DNA‐based computing. Other applications include catalysis, data storage, and biomimetics. The development of novel nanoporous crystalline materials with enhanced biocompatibility has opened up new avenues in the fields of nucleic acid analysis and therapy, paving the way for the development of sensitive, selective, and cost‐effective diagnostic and therapeutic tools with widespread applications.
Defect Passivation and Lithium Ion Coordination Via Hole Transporting Layer Modification for High Performance Inorganic Perovskite Solar Cells
Authors: Liu Yali , Xu Tianfei , Xu Zhuo , Zhang Hao , Yang Tengteng , Wang Zezhang , Xiang Wanchun , Liu Shengzhong 
Published: August 2023

AbstractMetal halide inorganic perovskite solar cells (PSCs) have great potential to achieve high efficiency with excellent thermal stability. However, the surface defect traps restrain the achievement of high open circuit voltage (VOC) and power conversion efficiency (PCE) of the devices due to the severe nonradiative charge recombination. Moreover, the state‐of‐the‐art hole transporting layer (HTL) significantly hampers device moisture stability, even though it renders the highest solar cell efficiency. Herein, a one‐stone‐two‐birds strategy is proposed using a biocompatible material tryptamine (TA) as an additive in HTL. First, TA bearing electron rich moieties can favorably passivate the surface defects of inorganic perovskite films, significantly reducing trap density and prolonging charge lifetime. It results in a drastic improvement of VOC from 1.192 to 1.251 V, with a VOC loss of 0.48 V. The corresponding PSCs achieve a 21.8% PCE under 100 mW cm−2 illumination. Second, TA in HTL can coordinate with lithium cations, retarding their reaction with moisture and increasing the moisture stability of HTL. Consequently, the black phase of inorganic perovskite films is well preserved, and the corresponding PSCs maintain 90% of the initial PCE after 800 h storage at relative humidity of 25–35%, much higher than the control devices.
Microfluidic‐Assembled Covalent Organic Frameworks@Ti3C2Tx MXene Vertical Fibers for High‐Performance Electrochemical Supercapacitors
Authors: Zhu Xiaolin , Zhang Yang , Man Zengming , Lu Wangyang , Chen Wei , Xu Jianhong , Bao Ningzhong , Chen Wenxing , Wu Guan 
Published: August 2023

AbstractThe delicate design of innovative and sophisticated fibers with vertical porous skeleton and eminent electrochemical activity to generate directional ionic pathways and good faradic charge accessibility is pivotal but challenging for realizing high‐performance fiber‐shaped supercapacitors (FSCs). Here, hierarchically ordered hybrid fiber combined vertical‐aligned and conductive Ti3C2Tx MXene (VA‐Ti3C2Tx) with interstratified electroactive covalent organic frameworks LZU1 (COF‐LZU1) by one‐step microfluidic synthesis is developed. Due to the incorporation of vertical channels, abundant redox active sites and large accessible surface area throughout the electrode, the VA‐Ti3C2Tx@COF‐LZU1 fibers express exceptional gravimetric capacitance of 787 F g−1 in a three‐electrode system. Additionally, the solid‐state asymmetric FSCs deliver a prominent energy density of 27 Wh kg−1, capacitance of 398 F g−1 and cycling life of 20 000 cycles. The key to high energy storage ability originates from the decreased ions adsorption energy and ameliorative charge density distribution in vertically aligned and active hybrid fiber, accelerating ions transportation/accommodation and interfacial electrons transfer. Benefiting from excellent electrochemical performance, the FSCs offer sufficient energy supply to power watches, flags, and digital display tubes as well as be integrated with sensors to detect pulse signals, which opens a promising route for architecting advanced fiber toward the carbon neutrality market beyond energy‐storage technology.
Unexpected Polymerization‐Induced Luminescence in Deep Eutectic Solvent (DES)‐Based Polymer
Authors: Qi Ping , Yuan Shideng , Liu Yihan , Dong Renhao , Song Aixin , Hao Jingcheng 
Published: August 2023

AbstractHere, a polymerizable type‐IV deep eutectic solvent (DES) is synthesized via the coordination reaction between acrylamide and SbCl3, and for the first time it is demonstrated that the resultant type‐IV DES‐based polymers can exhibit luminescence after polymerization due to the efficient Sb‐ligand and ligand–ligand charge transfer. Notably, the quantum yield of Sb‐ligand charge transfer emission can be tuned with the controllable reversible addition‐fragmentation chain transfer (raft) polymerization of acrylamide, reaching up to 15.32%. As a proof‐of‐concept application, the polymerizable DES is utilized as fluorescent anti‐counterfeit ink, successfully realizing the fluorescence encryption.
Liquid‐solid‐Interpenetration Surface Reconstruction of Monodisperse Water Stabilized CsPbBr3/CsPb2Br5 Core/Shell Perovskite Nanocrystals
Authors: Zhu Qiliang , Ye Fan , Yan Wei , Zhu Jingrun , Shen Jianhua , Xue Kan‐Hao , Zhu Yihua , Li Chunzhong 
Published: August 2023

AbstractAll‐inorganic lead halide perovskite nanocrystals (NCs) have shown great potential in various optoelectronic device applications due to their excellent optoelectronic properties, but their poor stability remains a key obstacle to widespread application. The preparation of core/shell NCs is developed to improve their stability, but most of the coating for single NCs is incomplete, and the crystal orientation and interface binding of core/shell structures are still unclear. Here, a surface reconstruction strategy to synthesize CsPbBr3/CsPb2Br5 core/shell NCs with uniform coating structure is reported. The concentration of [PbBr8]6− monomer in the system is regulated by creating local low H2O concentration conditions to balance the erosion of perovskite by water and the overall heterogeneous nucleation reaction system, resulting in single encapsulated and well‐edged perovskite core/shell NCs. More importantly, advanced characterization tools are used to reveal the core/shell structural features of CsPbBr3/CsPb2Br5 core/shell NCs at the atomic scale, which has not been reported before, and the interface matching of the two‐phase binding is simulated by density functional theory calculations, which confirm that the CsPb2Br5 (116) facet can bind to the CsPbBr3 (100) facet with the lowest binding energy. The prepared core/shell perovskite NCs can still retain photoluminescence emission after >30 days in water.
Electrochemical Three‐Component Reaction to ConstructN‐(α‐alkoxyalkyl)benzotriazoles
Authors: Liu Han‐Fu , Li Yang , Wang Guo‐Ao , Chen Kai‐Wei , Tang Hai‐Tao , Pan Ying‐Ming , He Mu‐Xue , Yang Ke‐Di , Huang Yong‐Lin 
Published: August 2023

AbstractN‐(α‐alkoxyalkyl)benzotriazoles are of great importance for biochemical and antitumor activity. A feasible protocol has been developed for the synthesis ofN‐(α‐alkoxyalkyl)benzotriazoles using azoles, aldehydes and alcohols as substrates under electrochemical conditions. The reaction is carried out under acid catalyst‐ and oxidant‐free conditions, so that a variety of synthetically useful nitrogen heterocyclic derivatives can be obtained. More meaningfully, a gram‐scale synthetic approach was employed to demonstrate the scale‐up applicability of this transformation.
A Competitive High‐Throughput Screening Platform for Designing Polylactic Acid‐Specific Binding Peptides
Authors: Lu Yi , Hintzen Kai‐Wolfgang , Kurkina Tetiana , Ji Yu , Schwaneberg Ulrich 
Published: August 2023

AbstractAmong biobased polymers, polylactic acid (PLA) is recognized as one of the most promising bioplastics to replace petrochemical‐based polymers. PLA is typically blended with other polymers such as polypropylene (PP) for improved melt processability, thermal stability, and stiffness. A technical challenge in recycling of PLA/PP blends is the sorting/separation of PLA from PP. Material binding peptides (MBPs) can bind to various materials. Engineered MBPs that can bind in a material‐specific manner have a high potential for material‐specific detection or enhanced degradation of PLA in mixed PLA/PP plastics. To obtain a material‐specific MBP for PLA binding (termed PLAbodies), protein engineering of MBP Cg‐Def for improved PLA binding specificity is reported in this work. In detail, a 96‐well microtiter plate based high‐throughput screening system for PLA specific binding (PLABS) was developed and validated in a protein engineering (KnowVolution) campaign. Finally, the Cg‐Def variant V2 (Cg‐Def S19K/K10L/N13H) with a 2.3‐fold improved PLA binding specificity compared to PP was obtained. Contact angle and surface plasmon resonance measurements confirmed improved material‐specific binding of V2 to PLA (1.30‐fold improved PLA surface coverage). The established PLABS screening platform represents a general methodology for designing PLAbodies for applications in detection, sorting, and material‐specific degradation of PLA in mixed plastics.
N‐Type Doping and Passivation of Black Phosphorus Using Pentacene for Infrared Polarization‐Sensitive Photodetection and Imaging
Authors: Li Guangliang , Kong Lingxian , Su Qi , Tan Xianhua , Zhang Xuning , Liu Zhiyong , Shi Tielin , Liao Guanglan , Sun Bo 
Published: August 2023

AbstractFew‐layer black phosphorus (FL‐BP) shows great potential in infrared polarization‐sensitive photodetection due to its narrow bandgap and strong in‐plane anisotropy. However, FL‐BP is easy to be oxidized and degraded, which severely restricts its applications. Herein, a simple and scalable in situ interfacial passivation method based on pentacene film is reported to enhance the ambient stability of FL‐BP as well as achieve n‐type doping for improved polarization‐sensitive photoimaging. High crystal quality FL‐BP flakes with intrinsic anisotropy are prepared by electrochemical exfoliation. The morphology and Raman spectra of FL‐BP/pentacene exhibit excellent stability 28 days after passivation. In addition, the hole mobility is significantly enhanced and dark current is substantially suppressed due to the interfacial passivation and n‐type doping effect. The FL‐BP/Pentacene based photodetector shows a broadband response from visible to near‐infrared with good stability. The photoresponsivity under 915 nm illumination is calculated as 2.2 mA W−1 with an anisotropy ratio of 1.29. Furthermore, the polarization imaging under the irradiation at zigzag and armchair directions directly reveals the strong infrared polarization‐sensitive imaging capability of FL‐BP/pentacene. This work also opens up new avenues to enhance the photoresponse and stability of various optoelectronics based on similarly unstable 2D materials.
Competitive Adsorption Mechanism of Defect‐Induced d‐Orbital Single Electrons in SrRuO3 for Alkaline Hydrogen Evolution Reaction
Authors: Pan Shencheng , Yang Xiaolong , Sun Jingwen , Wang Xin , Zhu Junwu , Fu Yongsheng 
Published: August 2023

AbstractIn the alkaline hydrogen evolution reaction (HER), the dissociation energy barrier of water, and the easy adsorption of OH on the catalyst are key factors that limit the catalytic activity. This work proposes a novel competing adsorption mechanism driven by dz2 electrons in the context of the alkaline HER. The high concentration of oxygen vacancies in Co doped SrRuO3 (V‐SRCO) results in the electron filling in the Ru 4dz2 orbital. Under alkaline conditions, the V‐SRCO exhibits a low overpotential of only 57.8 mV with a Tafel slope of 35 mV dec−1. Moreover, it exhibits sustained high activity for 60 h. The high HER activity of V‐SRCO can be attributed to the presence of a single electron in the dz2 orbital, which reduces the energy barrier for water dissociation. More importantly, the active electrons in the dz2 orbital can inject into the antibonding orbitals of OH, creating an unfavorable environment for OH adsorption on the catalyst. This work provides favorable conditions for efficient HER.
In Situ Pore Formation in Graphite Through Solvent Co‐Intercalation: A New Model for The Formation of Ternary Graphite Intercalation Compounds Bridging Batteries and Supercapacitors
Authors: Åvall Gustav , A. Ferrero Guillermo , Janßen Knut Arne , Exner Moritz , Son Youhyun , Adelhelm Philipp 
Published: August 2023

AbstractFor Li‐ion and Na‐ion batteries, the intercalation behavior of graphite anodes is quite different. While Li‐ions intercalate, Na‐ions only co‐intercalate with solvent molecules from the electrolyte solution leading to ternary graphite intercalation compound (t‐GIC) formation along with an expansion of the graphite interlayer spacing to 1.2 nm. This large interlayer spacing represents a micropore with parallel slit geometry. Little is known about t‐GIC formation, but it is commonly believed that throughout the reaction the ion is accompanied by either a full or partial solvation shell. Here, it is elucidated for the first time, using two independent methods – mass measurements and electrochemical impedance spectroscopy – supplemented by operando microscopy, entropymetry and simulations, that the storage mechanism is far more complex. A new model for the electrochemical solvent co‐intercalation process is proposed: As soon as solvated ions enter, the graphite structure is flooded with free solvents, which are subsequently replaced by solvated ions. Close to full sodiation, few free solvents remain and structural rearrangement take place to reach the full storage capacity. Thus, t‐GICs represent a unique case of switchable microporous systems and hence appear as a bridge between ion storage in the bulk phase and in micropores, i.e., between batteries and supercapacitors.
Realizing efficient emission and triple‐mode photoluminescence switching in air‐stable tin(IV)‐based metal halides via antimony doping and rational structural modulation
Authors: He Xuefei , Peng Hui , Wei Qilin , Zhou Zhijie , Zhang Guolun , Du Zhentao , Zhao Jialong , Zou Bingsuo 
Published: August 2023

AbstractRecently, many lead‐free metal halides with diverse structures and highly efficient emission have been reported. However, their poor stability and single‐mode emission color severely limit their applications. Herein, three homologous Sb3+‐doped zero‐dimensional (0D) air‐stable Sn(IV)‐based metal halides with different crystal structures were developed by inserting a single organic ligand into SnCl4 lattice, which brings different optical properties. Under photoexcitation, (C25H22P)SnCl5@Sb·CH4O (Sb3+−1) does not emit light, (C25H22P)2SnCl6@Sb‐α (Sb3+−2α) shines bright yellow emission with a photoluminescence quantum yield (PLQY) of 92%, and (C25H22P)2SnCl6@Sb‐β (Sb3+−2β) exhibits intense red emission with a PLQY of 78%. The above three compounds show quite different optical properties should be due to their different crystal structures and the lattice distortions. Particularly, Sb3+−1 can be successfully converted into Sb3+−2α under the treatment of C25H22PCl solution, accompanied by a transition from nonemission to efficient yellow emission, serving as a “turn‐on” photoluminescence (PL) switching. Parallelly, a reversible structure conversion between Sb3+−2α and Sb3+−2β was witnessed after dichloromethane or volatilization treatment, accompanied by yellow and red emission switching. Thereby, a triple‐mode tunable PL switching of off–onI–onII can be constructed in Sb3+‐doped Sn(IV)‐based compounds. Finally, we demonstrated the as‐synthesized compounds in fluorescent anticounterfeiting, information encryption, and optical logic gates.
A 3‐year follow‐up study after nasal reconstruction surgery in patients with empty nose syndrome
Authors: Huang Chien‐Chia , Wu Pei‐Wen , Huang Chi‐Che , Chang Po‐Hung , Fu Chia‐Hsiang , Lee Ta‐Jen 
Published: August 2023

Key Points
Empty nose syndrome (ENS) is characterized by a patent nasal airway and a sense of nasal obstruction.
ENS and psychological symptoms improved after surgery and remained stable for up to three years.
Identifying residual disease is necessary for enhancing therapeutic outcomes in ENS patients.