bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytotoxic Effect of 6-Ethyl-Chenodeoxycholic Acid and Cabazitaxel on PC-3 Cells
Authors: Zalzala M. H. , Al-khfajy W. S. , Khaleel R. A. 
Published: February 2023

Introduction. Chemotherapy with Cabazitaxel (CBZ) is a typical first-line treatment option for naïive castration-resistant prostate cancer resistant to docetaxel. On the other hand, Cabazitaxel's therapeutic success is constrained by chemoresistance and side effects.Aim. To assess whether 6 alpha-ethylchenodeoxycholic acid (6-ECDCA), a selective agonist for bile acid receptors will enhance the efficacy of CBZ in androgen-independent prostate cancer cells.Materials and methods. The 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) viability assay was used to assess the cytotoxicity of 6-ECDCA and CBZ medicines or their combinations against the human prostate cancer cell line (PC-3). The combination outcome suggested by Chou TC et al. was then evaluated using the combination index (CI) to find out the nature of synergism, antagonism, and additive effect of the drug’s combination. Furthermore, the Dose-Reduction Index (DRI) was determined to measure how many times the dose could be reduced for each drug in a synergistic combination.Results and discussion. Analysis of the dose-effect curve showed that the treatment of PC-3 cells with CBZ alone or combined with 6-ECDCA for 48 h led to 50 % cytotoxicity of 20.5 nM and 4.7 nM, respectively. 6-ECDCA at 1.77 µM had an additive effect based on the CI value, which was 1.02, while at 21.02 µM, the CI was 0.54 which designates a strong synergistic effect. The combination of CBZ and 6-ECDCA at a submaximal lower dose by 6-folds of each one produced a 95 % cell death than treatment with either agent alone.Conclusion. The Combination index plot showed CI ≤ l for all combinations used in this study, which indicates additive and synergistic interactions between CBZ and 6-ECDCA. The significant impact of 6-ECDCA in combination with CBZ for treating androgen-independent prostate cancer cells was confirmed by this study to be preferred to the treatment with a single drug.
Development and Validation of Analytical HPLC Method for Identification and Assay of Enoxaparin Sodium in Injectable Preparations
Authors: Pshenichnov E. A. , Kondrasheva K. V. 
Published: February 2023

Introduction. Enoxaparin sodium-containing drugs are included in relevant protocols for COVID-19 therapy. An increase in the production volume of such drugs leads to a demand for available and precise methods of identification and quantitative measurement of the active ingredient in the preparations. Considering the fact that pharmacopoeial methods require significant amount of expensive standards and reagents that are unavailable for numerous laboratories, it is relevant to develop a more available method that will accelerate and make cheaper the process of quality control for enoxaparin sodium-containing preparations.Aim. To develop and validate a simple, economic, and precise method of gel-permeation HPLC with the application of a refractive index detector for the evaluation of enoxaparin sodium in preparations for injection.Materials and methods. Samples of enoxaparin sodium-containing substances and commercial preparations were studied. The identification and quantitative content of the active ingredient were performed by the method of gel-permeation HPLC using a 1260 Infinity (Agilent Technologies, USA) chromatograph equipped with a refractive index detector.Results and discussion. The authors analyzed standard validation characteristics: specificity, linearity, precision, and accuracy of the method. The analysis revealed high specificity and suitability of the proposed method to chromatographic symmetrical multiprocessing systems. The method is recommended for routine control of finished and semi-finished pharmaceutical preparations containing from 25 to 200 mg/ml of enoxaparin sodium-containing.Conclusion. The proposed method can be used for routine quality control of enoxaparin sodium-containing preparations for injection.
LOGÍSTICA REVERSA NO FATECLOG
Authors: Barros Laércio de Jesus 
Published: February 2023

Os discursos referentes às práticas de Logística Reversa, ao longo dos últimos anos, vêm ganhando força nos debates e estudos referentes ao desenvolvimento das economias ao redor do mundo. Tem-se discutido a necessidade da Logística Reversa buscando-se aumentar a compreensão sobre o papel das empresas no contexto do Desenvolvimento Sustentável. Esta obra teve como principal objetivo analisar quantitativamente como se comportou a produção científica sobre a temática, materializada na forma de artigos digitais e publicados nos anais do FATECLOG. Como resultado, averiguou-se que o ano com maior percentual de publicações no período foi 2018 onde 24 artigos foram publicados; constatou-se que os autores não dão continuidade nas pesquisas, pois dentro de um universo de 315 autores encontrados, 93% publicaram apenas 01 artigo no período analisado; a Faculdade de Tecnologia (FATEC) – na cidade de AMERICANA colaborou com 18% do total de artigos encontrados; Em relação à autoria Adalberto Zorzo é o mais profícuo, com 07 publicações, e os seis autores que mais colaboraram foram responsáveis pela publicação de aproximadamente 25% do total dos arquivos encontrados nos anais do FATECLOG. Ficou constatado que 95% dos artigos foram publicados em parceria, e destas, a parceria de 03 autores fica em evidência com 33% dos artigos encontrados.
The molecular basis of differential host responses to avian influenza viruses in avian species with differing susceptibility
Authors: Morris Katrina M. , Mishra Anamika , Raut Ashwin A. , Gaunt Eleanor R. , Borowska Dominika , Kuo Richard I. , Wang Bo , Vijayakumar Periyasamy , Chingtham Santhalembi , Dutta Rupam , Baillie Kenneth , Digard Paul , Vervelde Lonneke , Burt David W. , Smith Jacqueline 
Published: February 2023

IntroductionHighly pathogenic avian influenza (HPAI) viruses, such as H5N1, continue to pose a serious threat to animal agriculture, wildlife and to public health. Controlling and mitigating this disease in domestic birds requires a better understanding of what makes some species highly susceptible (such as turkey and chicken) while others are highly resistant (such as pigeon and goose). Susceptibility to H5N1 varies both with species and strain; for example, species that are tolerant of most H5N1 strains, such as crows and ducks, have shown high mortality to emerging strains in recent years. Therefore, in this study we aimed to examine and compare the response of these six species, to low pathogenic avian influenza (H9N2) and two strains of H5N1 with differing virulence (clade 2.2 and clade 2.3.2.1) to determine how susceptible and tolerant species respond to HPAI challenge.MethodsBirds were challenged in infection trials and samples (brain, ileum and lung) were collected at three time points post infection. The transcriptomic response of birds was examined using a comparative approach, revealing several important discoveries.ResultsWe found that susceptible birds had high viral loads and strong neuro-inflammatory response in the brain, which may explain the neurological symptoms and high mortality rates exhibited following H5N1 infection. We discovered differential regulation of genes associated with nerve function in the lung and ileum, with stronger differential regulation in resistant species. This has intriguing implications for the transmission of the virus to the central nervous system (CNS) and may also indicate neuro-immune involvement at the mucosal surfaces. Additionally, we identified delayed timing of the immune response in ducks and crows following infection with the more deadly H5N1 strain, which may account for the higher mortality in these species caused by this strain. Lastly, we identified candidate genes with potential roles in susceptibility/resistance which provide excellent targets for future research.DiscussionThis study has helped elucidate the responses underlying susceptibility to H5N1 influenza in avian species, which will be critical in developing sustainable strategies for future control of HPAI in domestic poultry.
Comparison of the endoscopic thyroidectomy via areola approach and open thyroidectomy: A propensity score matched cohort study of 302 patients in the treatment of papillary thyroid non-microcarcinoma
Authors: Li Yujun , Liu Zhaodi , Song Zhuolin , Wang Yong , Yu Xing , Wang Ping 
Published: February 2023

BackgroundThe endoscopic thyroidectomy via areola approach (ETAA) is widely used in patients with benign thyroid tumors and papillary thyroid microcarcinoma (PTMC). Its safety and complication rates are reported to be similar to open thyroidectomy (OT). This study aimed to evaluate the safety and feasibility of ETAA, compared with OT, in patients with papillary thyroid non-microcarcinoma (PTNMC).MethodsWe retrospectively reviewed all patients with PTNMC who underwent ETAA or OT in our hospital from January 2017 to December 2021. A total of 302 patients were matched at a ratio of 1:1 by the propensity score matching (PSM) analysis and surgical outcomes. Safety and feasibility were analyzed between two groups.ResultsBefore PSM, patients in the ETAA group were younger (p &lt; 0.001) and had a larger proportion of female patients (p &lt; 0.001) with a lower BMI (p &lt; 0.001) compared with the OT group. The ETAA group also had a higher proportion of unilateral thyroidectomy (p = 0.002). PSM was used to create a highly comparable control group. After PSM, the ETAA group had a longer operative time (p &lt; 0.001), larger blood loss (p = 0.046) and total drainage amount (p = 0.035), with higher C-reactive protein (p = 0.023) and better cosmetic outcomes (p &lt; 0.001). There were no significant differences in the following clinicopathologic characteristics: number of dissected positive lymph nodes, rate of recurrent laryngeal nerve signal weakened, parathyroid autotransplantation, postoperative pain, hospital stay, complications, and oncologic completeness. There was no patient converted to OT in the ETAA group and two patients suffered from persistence/recurrence in the follow-up.ConclusionETAA is a safe and feasible surgical approach for patients with PTNMC.
A Two-Stage Optimization Approach for Healthcare Facility Location- Allocation Problems With Service Delivering Based on Genetic Algorithm
Authors: Salami Azadeh , Afshar-Nadjafi Behrouz , Amiri Maghsoud 
Published: February 2023

Objective: This study assesses a multi-period capacitated maximal-covering location-allocation model for healthcare services, taking interservice referral as well as equity access into account.Methods: A two-stage optimization strategy is used to formulate the model. In the first stage, facilities are located to maximize covered demand, and in the second stage, patients are allocated to capacitated facilities based on their radius of coverage over multiple time periods. The problem, which belongs to the NP-hard class of optimization problems, is solved using a linear mixed-integer programming (MILP) model.Results: A numerical example is presented to evaluate the efficiency of the proposed model. In addition, to identify near-optimal solutions for large instances, a hybrid genetic-sequential quadratic programming approach (GA-SQP) is developed. To examine the performance and efficiency of the GA-SQP, we employed several randomly generated test instances of various sizes and compared them to those obtained using the exact method.Conclusion: The proposed model has demonstrated an excellent ability in locating healthcare facilities and allocating health services while taking shortage and equity into account during each time period.
Modal Representation of Inertial Effects in Fluid–Particle Interactions and the Regularity of the Memory Kernels
Authors: Procopio Giuseppe , Giona Massimiliano 
Published: February 2023

This article develops a modal expansion (in terms of functions exponentially decaying with time) of the force acting on a micrometric particle and stemming from fluid inertial effects (usually referred to as the Basset force) deriving from the application of the time-dependent Stokes equation to model fluid–particle interactions. One of the main results is that viscoelastic effects induce the regularization of the inertial memory kernels at t=0, eliminating the 1/t-singularity characterizing Newtonian fluids. The physical origin of this regularization stems from the finite propagation velocity of the internal shear stresses characterizing viscoelastic constitutive equations. The analytical expression for the fluid inertial kernel is derived for a Maxwell fluid, and a general method is proposed to obtain accurate approximations of it for generic complex viscoelastic fluids, characterized by a spectrum of relaxation times.
Study of Potential Synergistic Effect of Probiotic Formulas on Acrylamide Reduction
Authors: Choi Siu Mei , Lin Hongyu , Xie Weiying , Chu Ivan K. 
Published: February 2023

Acrylamide (AA) is a food processing contaminant commonly found in fried and baked food products. In this study, the potential synergistic effect of probiotic formulas in reducing AA was studied. Five selected probiotic strains (Lactiplantibacillus plantarum subsp. plantarum ATCC14917 (L. Pl.), Lactobacillus delbrueckii subsp. bulgaricus ATCC11842 (L. B.), Lacticaseibacillus paracasei subsp. paracasei ATCC25302 (L. Pa), Streptococcus thermophilus ATCC19258, and Bifidobacterium longum subsp. longum ATCC15707) were selected for investigating their AA reducing capacity. It was found that L. Pl. (108 CFU/mL) showed the highest AA reduction percentage (43–51%) when exposed to different concentrations of AA standard chemical solutions (350, 750, and 1250 ng/mL). The potential synergistic effect of probiotic formulas was also examined. The result demonstrated a synergistic AA reduction effect by the probiotic formula: L. Pl. + L. B., which also showed the highest AA reduction ability among the tested formulas. A further study was conducted by incubating selected probiotic formulas with potato chips and biscuit samples followed by an in vitro digestion model. The findings demonstrated a similar trend in AA reduction ability as those found in the chemical solution. This study firstly indicated the synergistic effect of probiotic formulas on AA reduction and its effect was also highly strain-dependent.
Chemical Defense against Herbivory in the Brown Marine Macroalga Padina gymnospora Could Be Attributed to a New Hydrocarbon Compound
Authors: Pereira Renato Crespo , Paradas Wladimir Costa , de Carvalho Rodrigo Tomazetto , de Lima Moreira Davyson , Kelecom Alphonse , Passos Raoni Moreira Ferreira , Atella Georgia Correa , Salgado Leonardo Tavares 
Published: February 2023

Brown marine macroalga Padina gymnospora (Phaeophyceae, Ochrophyta) produces both secondary metabolites (phlorotannins) and precipitate calcium carbonate (CaCO3—aragonite) on its surface as potential defensive strategies against herbivory. Here, we have evaluated the effect of natural concentrations of organic extracts (dichloromethane—DI; ethyl acetate—EA and methanol—ME, and three isolated fractions) and mineralized tissues of P. gymnospora as chemical and physical resistance, respectively, against the sea urchin Lytechinus variegatus through experimental laboratory feeding bioassays. Fatty acids (FA), glycolipids (GLY), phlorotannins (PH) and hydrocarbons (HC) were also characterized and/or quantified in extracts and fractions from P. gymnospora using nuclear magnetic resonance (NMR) and gas chromatography (GC) coupled to mass spectrometry (CG/MS) or GC coupled to flame ionization detector (FID) and chemical analysis. Our results showed that chemicals from the EA extract of P. gymnospora were significantly important in reducing consumption by L. variegatus, but the CaCO3 did not act as a physical protection against consumption by this sea urchin. An enriched fraction containing 76% of the new hydrocarbon 5Z,8Z,11Z,14Z-heneicosatetraene exhibited a significant defensive property, while other chemicals found in minor amounts, such as GLY, PH, saturated and monounsaturated FAs and CaCO3 did not interfere with the susceptibility of P. gymnospora to L. variegatus consumption. We suggest that the unsaturation of the 5Z,8Z,11Z,14Z-heneicosatetraene from P. gymnospora is probably an important structural characteristic responsible for the defensive property verified against the sea urchin.
Designing Travel Pattern of Cultural Journey To Broaden Tourist Dispersion throughout Flores Island
Authors: Istanto Ismayanti , Djamhur Ina 
Published: February 2023

A travel pattern that can be suitable with the shift of travel behavior is a must, so as, the purpose of the study is: (1) to do curation cultural-based attraction overland Flores and (2) cluster them into a thematic travel pattern that suit the travel time, travel distance and tourist dispersion. Multi-destination model is used in designing the pattern based on data collected through survey, interview and FGD with stakeholders from eight region of Flores and analyzed through exploratory sequence method. The finding shows from initial 196 cultural based attration, only 35 points of interest matched and are ready to be visited as in favored by stakeholders. As multi-destination, travel pattern are constructed on en-route and base-camp pattern. Three theme, then, came as cluster of (1) weaving; (2) traditional village; and (3) gastronomic. Weaving tour routes is consisted of 10 attractions, traditional village is comprised of 12 attractions and gastronomic route is contained of 13 attractions. Implication of study are as for travel industry, many creation of tour ativities and packages can be made, and as for tourist, it is a guide to explore the overland of Flores with cultural thematic.
Karakteristik Ragam Bahasa Penjual Pembeli dalam Grup Jual Beli di Facebook
Authors: Purba Bella , Sabardilla Atiqa 
Published: February 2023

Tujuan dari penelitian ini adalah memaparkan pola karakteristik ragam bahasa yang digunakan penjual dan pembeli dalam grup jual beli di Facebook, kemudian mendesripsikan ragam bahasa yang digunakan penjual dan pembeli dalam grup jual beli di Facebook. Penelitian ini merupakan penelitian deskriptif kualitatif. Data yang diambil berupa kalimat dan paragraf. Sumber data penelitian ini yaitu grup jual beli yang ada di Facebook. Teknik pengumpulan data yang digunakan teknik simak catat. Data divalidasi dengan teknik triangulasi teori. Kemudian data dianalisis dengan metode agih dengan teknik baca markah dan metode padan referensial. Hasil penelitian menunjukkan bahwa terdapat dua karakteristik ragam bahasa yang digunakan penjual dan pembeli dalam grup jual beli di Facebook yaitu menggunakan kata monggo dan kata ready untuk menawarkan barang yang dijualnya. Adapun bahasa yang digunakan yaitu bahasa Indonesia ragam takbaku, bahasa daerah (jawa) dan bahasa asing (Inggris). Sedangkan bahasa yang digunakan penjual dan pembeli dalam grup jual beli di Facebook yaitu menggunakan ragam bahasa tidak baku. Adapun bahasa yang digunakan dalam penawarannya berupa campuran bahasa Indonesia, bahasa Inggris dan bahasa Jawa.
Homestay Innovation Capability in a Property Business Perspective
Authors: Priyatiningsih Katharina 
Published: February 2023

The rapid development of entrepreneurship-based tourism has encouraged households in tourist areas to try to take advantage of opportunities to do business through residential property to become homestays. Homestays are offered for tourists who want to spend the night naturally, enjoy daily life with the local culture of the destination visited with all the facilities which of course can meet the needs of traveling. Residential home owners try to become property entrepreneurs by understanding the management of the property business through innovation capabilities that transform residential homes into homestays. The needs of tourists in choosing homestay accommodation are different from hotels or villas or bungalows, preferring to enjoy a homely atmosphere by getting memories and local experiences in tourist destination areas. Residential homeowners will seek information regarding home repairs and the physical availability of residential homes, arrange schedules, and need to study property management in collaboration with residential developers. So this study aims to determine the innovation ability of homestay property developers who are considered influential in increasing business through the dimensions of technology development, operational capabilities, managerial routines and property transactions. This descriptive research with quantitative and qualitative approaches uses triangulation data collection techniques and is statistically analyzed using Partial Least Square. It is important for homestay business owners to find building developers who can repair or rearrange buildings who have the ability to innovate in the property business. The results of measurements from residential home owners and property developers in tourist destinations show that the dimensions of strong property innovation capabilities are innovation capabilities in management and routine operations, while the dimensions of innovation capabilities that still have weaknesses are innovation capabilities in technology development and transactions.

Keywords: Innovation capability; homestays ; Property Business.
Transformasi Produk Agen Perjalanan Wisata Selama Pandemi Covid-19 di Indonesia
Authors: Githa Bagus , Mardhiyati Syihap Mufriha , Ramadina Shafira , Chrisantori Victor 
Published: February 2023

Pandemi Covid-19 telah menghantam industri pariwisata dan ekonomi kreatif di Indonesia. Sejak Februari 2020 jumlah wisatawan mancanegara yang masuk ke Indonesia mengalami penurunan yang sangat drastis, dan puncaknya terjadi pada April 2020. Degan berbagai kebijakan yang dikeluarkan oleh pemerintah, maka perubahan perlu dilakukan oleh agen perjalanan wisata agar bertahan. Inovasi berarti senantiasa menjadi relevan yang dibanggakan di segala zaman. (Febransyah, 2016). Penelitian ini dilakukan untuk menggali informasi lebih dan menyeluruh sehingga dapat mewakili agen perjalanan di Indonesia. Maka dari itu, penulis melakukan penelitian lebih dalam yang disusun dalam makalah: TRANSFORMASI PRODUK AGEN PERJALANAN WISATA SELAMA PANDEMI COVID-19 DI INDONESIA dengan lokus Jakarta dan Bandung. Perusahaan yang dijadikan tempat penulis untuk penelitian diantara lain adalah Bima Tour Bandung, Antavaya Bandung, Golden Rama Bandung, ESQ Tour Jakarta, MyTours Jakarta. Metode yang digunakan adalah kualitatif dengan teknik pengumpulan data melalui Wawancara dan Studi Pustaka.Berdasarkan hasil penelitian dapat disimpulkan bahwa semua produk agen perjalanan wisata seperti tour, tiket dan hotel terdampak dikarenakan Covid-19 yang melanda Indonesia. Alasannya adalah karena produk tersebut tidak dapat dijual oleh agen perjalanan wisata karena produk tidak dapat dijalankan. Ditemukan bahwa 3 dari agen perjalanan wisata melakukan transformasi produk berupa Virtual Tour, Penjualan Alat Kesehatan, Kuliner dan Kajian Online dan 2 perusahaan tidak melakukan transformasi produk dengan mengandalkan penjualan ke coorporate untuk bertahan
Keywords: Produk Transformasi, Agen Perjalanan Wisata, Covid-19.