bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aminoglycosides: Single- or Multiple-daily Dosing? An Updated Qualitative Systematic Review of Randomized Trials on Toxicity and Efficacy
Authors: Karimzadeh Iman , Abdollahpour-Alitappeh Meghdad , Ghaffari Shokouh , Mahi-Birjand Motahareh , Barkhordari Amin , Alemzadeh Effat 
Published: August 2023

Introduction:
Aminoglycosides are among the first-choice antibiotics for
routine clinical use. However, dose-limiting factors such as ototoxicity and nephrotoxicity
are considered as serious complications of aminoglycosides.

Objective:
In this systematic review, the main goal was to investigate the efficacy and
incidence of nephrotoxicity and ototoxicity of once-daily dosing (ODD) and multiple daily
dosing (MDD) regimens of aminoglycosides through available randomized controlled
trials (RCTs).

Methods:
We performed a literature-based research in relevant databases, including
EMBASE, MEDLINE, and SCOPUS published between 1987 and 2023 using the
keywords “aminoglycosides”, “pharmacokinetics”, “ODD”, “MDD”, “once daily”, “multiple
daily”, “dosing regimen”, “nephrotoxicity”, “ototoxicity”, “efficacy”, “safety”, and “toxicity”.
As so told, the results of this article were limited to papers available in English. Our initial
search yielded 1124 results. After a review of the titles and abstracts of the articles, 803
articles were excluded from this study because they did not address the toxicity and
effectiveness of ODD versus MDD of aminoglycosides. A total number of 20 studies on
gentamicin, tobramycin, netilmicin, and amikacin met the inclusion criteria for the
efficacy of aminoglycosides and their role in ototoxicity and nephrotoxicity were included
in this review. Studies recruited different age classes, and the age of relevant cohorts
varied from only a few days to more than 70 years.

Results:
The most common clinical
condition in the included studies was cystic fibrosis.

Conclusion:
In most studies, there were no significant differences between the two
regimens regarding ototoxicity. In addition, the ODD regimens were safer than MDD
concerning nephrotoxicity.
Functional MRI Techniques Suggesting that the Stress System Interacts
with Three Large Scale Core Brain Networks to Help Coordinate the
Adaptive Response: A Systematic Review
Authors: Paltoglou George , Stefanaki Charikleia , Chrousos George P. 
Published: August 2023

Objective:
Synthesis of functional MRI (fMRI) and functional connectivity (FC) analysis
data on human stress system (SS) function, as it relates to the dynamic function of the Salience (SN),
Default Mode (DMN) and Central Executive (CEN) networks.

Methods:
Systematic search of Medline, Scopus, Clinical Trials.gov, and Google Scholar databases of
studies published prior to September 2022 resulted in 28 full-text articles included for qualitative synthesis.

Results:
Acute stress changes the states of intra-/inter- neural network FCs and activities from those of
resting, low arousal state in the SN, DMN and CEN, during which intra- and inter-network FCs and
activities of all three networks are low. SS activation is positively linked to the activity of the SN and
negatively to that of the DMN, while, in parallel, it is associated with an initial decrease and a subsequent
increase of the intra- network FC and activity of the CEN. The FC between the DMN and the
CEN increases, while those between the SN and the CEN decrease, allowing time for frontal lobe
strategy input and “proper” CEN activity and task decision. SN activation is linked to sensory hypersensitivity,
“impaired” memory, and a switch from serial to parallel processing, while trait mindfulness
is associated with FC changes promoting CEN activity and producing a “task-ready state”.

Conclusion:
SS activation is tightly connected to that of the SN, with stress hormones likely potentiating
the intra-network FC of the latter, attenuating that of the DMN, and causing a biphasic suppression-
to-activation response of the CEN, all adaptive changes favoring proper decisions and survival.
Peripheral Nervous System Pain Modulation
Authors: Karcz Marcin , Gharibo Christopher 
Published: August 2023

Abstract:
The percutaneous technique of electrode insertion in the vicinity of the greater occipital
nerves to treat occipital neuralgia was first described in the 1990s by Weiner and Reed. This subsequently
stimulated awareness of peripheral nerve stimulation (PNS). The more recent advent emergence
of a minimally invasive percutaneous approach by way of using ultrasound has further increased
the interest in PNS as a viable alternative to more invasive techniques. PNS has become more popular
recently and is increasingly used to treat various pain conditions. Its foundation is fundamentally
based on the gate control theory, although the precise mechanism underlying its analgesic effect is still
indefinite. Studies have demonstrated the peripheral and central analgesic mechanisms of PNS by
modulating the inflammatory pathways, the autonomic nervous system, the endogenous pain inhibition
pathways, and the involvement of the cortical and subcortical areas. Peripheral nerve stimulation
exhibits its neuromodulatory effect both peripherally and centrally. Further understanding of the modulation
of PNS mechanisms can help guide stimulation approaches and parameters to optimize the use
of PNS. his chapter aims to review the background and mechanisms of PNS modulation. PNS is becoming
one of the most diverse therapies in neuromodulation due to rapid evolution and expansion. It
is an attractive option for clinicians due to the simplicity and versatility of procedures that can be
combined with other neuromodulation treatments or used alone. It has a distinct role in the modulation
of functional conditions.
Neurotensin and Neurotensin Receptors in Stress-related Disorders:
Pathophysiology & Novel Drug Targets
Authors: Kyriatzis Grigorios , Khrestchatisky Michel , Ferhat Lotfi , Chatzaki Ekaterini Alexiou 
Published: August 2023

Abstract:
Neurotensin (NT) is a 13-amino acid neuropeptide widely distributed in the CNS that has
been involved in the pathophysiology of many neural and psychiatric disorders. There are three known
neurotensin receptors (NTSRs), which mediate multiple actions, and form the neurotensinergic system
in conjunction with NT. NTSR1 is the main mediator of NT, displaying effects in both the CNS and
the periphery, while NTSR2 is mainly expressed in the brain and NTSR3 has a broader expression pattern.
In this review, we bring together up-to-date studies showing an involvement of the neurotensinergic
system in different aspects of the stress response and the main stress-related disorders, such as
depression and anxiety, post-traumatic stress disorder (PTSD) and its associated symptoms, such as
fear memory and maternal separation, ethanol addiction, and substance abuse. Emphasis is put on
gene, mRNA, and protein alterations of NT and NTSRs, as well as behavioral and pharmacological
studies, leading to evidence-based suggestions on the implicated regulating mechanisms as well as
their therapeutic exploitation. Stress responses and anxiety involve mainly NTSR1, but also NTSR2
and NTSR3. NTSR1 and NTSR3 are primarily implicated in depression, while NTSR2 and secondarily
NTSR1 in PTSD. NTSR1 is interrelated with substance and drug abuse and NTSR2 with fear
memory, while all NTSRs seem to be implicated in ethanol consumption. Some of the actions of NT
and NTSRs in these pathological settings may be driven through interactions between NT and corticotrophin
releasing factor (CRF) in their regulatory contribution, as well as by NT’s pro-inflammatory
mediating actions.
α,α-Dibromoketones as Synthetic Equivalents of α-Bromoketones for the
Synthesis of Thiazolo[3,2-a]benzimidazoles
Authors: Kumar Ravi , Nair Reshmi R , Prakash Richa , Bae Taeho , Dohi Toshifumi , Prakash Om 
Published: August 2023

Abstract:
Utilization of α,α-dihalocarbonyl compounds as synthetic equivalents to α-halocarbonyl
compounds has been explored in the synthesis of a wide range of highly useful heterocycles and α-
functionalized ketones. The continuously growing demand of α,α-dibromoketones, as highly reactive
and mild synthetic precursors/intermediates, to carry out selective organic transformations, prompted
us to investigate their potential application for the synthesis of thiazolo[3,2-a]benzimidazoles. In this
study, a remarkable application of α,α-dibromoacetophenones 5a-g in the development of a facile protocol
for the synthesis of thiazolo[3,2-a]benzimidazoles 4a-g by avoiding the use of lachrymatory α-
haloketones is described. Although the mechanism for the debromination from the intermediate compound
6 under these conditions is not confirmed, possible pathways have been suggested.
The Role of Gender in Turkish Women’s Pregnancy Experiences
Authors: Özer Betül Uzun , Topatan Serap 
Published: August 2023

Background:
Apart from the biological changes women experience throughout pregnancy, their exposure to a gender discrimination stemming from cultural values adopted by the society in which they live can make it difficult for them to adapt to pregnancy and thus lead to negative pregnancy experiences.

Aim:
This research was conducted using a cross-sectional and relation-seeking approach to evaluate the effects of social gender inequality on pregnancy experiences.

Methods:
Data for this cross-sectional and relation-seeking study were gathered between 25 November 2019 and 25 January 2020 using face-to face interviews the researcher conducted with childbearing women who visited the outpatient clinic and non-stress test units of a hospital for the pregnancy follow-up.

Results::
When using the Pregnancy Experiences Scale to assess childbearing women, higher scores indicated more positive emotions than negative emotions. Independent variables that affect the scores on the Pregnancy Experiences Scale include a willingness to be pregnant, the baby's sex, the woman’s income status, gestational week and the Perception of Gender Scale (p< 0.005). A positive but weakly significant relationship was found among the total score on the Perception of Gender Scale, the total score on the Pregnancy Experiences Scale and the average scores of positive emotions intensity and frequency in all sub-dimensions (p< 0.005).

Conclusion:
Based on the data, we conclude that women’s pregnancy experiences are generally positive, and that social gender inequality is a significant determinant affecting pregnancy experiences.
A Comprehensive Review on Prospects of Polymeric Nanoparticles for
Treatment of Diabetes Mellitus: Receptors-Ligands, In vitro & In vivo
Studies
Authors: Jain Arinjay , Dawre Shilpa 
Published: August 2023

Abstract:
As per International Diabetes Federation Report 2022, worldwide diabetes mellitus (DM)
caused 6.7M moralities and ~537M adults suffering from diabetes mellitus. It is a chronic condition due
to β-cell destruction or insulin resistance that leads to insulin deficiency. This review discusses Type-1
DM and Type-2 DM pathophysiology in detail, with challenges in management and treatment. The toxicity
issues of conventional drugs and insulin injections are complex to manage. Thus, there is a need
for technological intervention. In recent years, nanotechnology has found a fruitful advancement of
novel drug delivery systems that might potentially increase the efficacy of anti-diabetic drugs. Amongst
nano-formulations, polymeric nanoparticles have been studied to enhance the bioavailability and efficacy
of anti-diabetic drugs and insulin. In the present review, we summarized polymeric nanoparticles
with different polymers utilized to deliver anti-diabetic drugs with in vitro and in vivo studies. Furthermore,
this review also includes the role of receptors and ligands in diabetes mellitus and the utilization
of receptor-ligand interaction to develop targeted nanoparticles. Additionally, we discussed the utility of
nanoparticles for the delivery of phytoconstituents which aids in protecting the oxidative stress generated
during diabetes mellitus. Atlast, this article also comprises of numerous patents that have been filed
or granted for the delivery of antidiabetic and anticancer molecules for the treatment of diabetes mellitus
and pancreatic cancer.
Synthesis of New Zirconium (IV) Schiff-base Complexes: Spectral, Theoretical,
and Molecular Docking Studies
Authors: Dhingra Naveen , Khaturia S. , Solanki VS , Singh Har Lal 
Published: August 2023

Background:
The development of the discipline of coordination chemistry owes a great deal to the use of Schiff-base metal chelates. Both Schiff base ligands and metal complexes are of interest due to their potential pharmacological effects. Schiff base derivatives have an extensive range of biological effects, including antitumor, antifungal, antibacterial, anticonvulsant, and antiviral properties.

Objective:
This study aimed to study the inorganic compound-based metallodrugs that have recently come into existence to provide an effective mechanism for medications that depend on the metal used and its characteristics. An effective platform for diverse pharmacological and therapeutic uses can be found in medicinal complex substances.

Methods:
The bi-molar reactions of zirconium tetrachloride with bidentate ligands were carried out in dry THF and were characterized by IR, UV-Visible, NMR and C, H, N, S analysis. The DFT method was used to investigate the molecular stability and bond strengths. Gaussian 09 and MolDock were used to optimise the geometry and to calculate the binding energy of all the complexes, respectively.

Results:
The analysis of the data revealed that the Schiff base, which has bivalent ligands (NS), was coordinated to zirconium via nitrogen and sulfur atoms. The optimum values for the structural parameters were calculated by density functional theory. Compound 5 showed the highest MolDock Score (-123.47 kcal/ mol) and H-bond interaction with active amino acids.

Conclusion:
The spectroscopic result indicates that the zirconium compounds were all non-electrolyte monomers with deformed octahedral structures. Compound 5 was shown to be the most active and effective of the bunch by both Gaussian software calculations and molecular docking study.
Herbal Remedies: An Emerging Alternative for the Treatment of Pandemic Diseases
Authors: Nistane Neha T. , Kale Mayur B. , Das Renuka J. , Umare Mohit D. , Umekar Milind J. , Hemke Atul T. , Gajbhiye Vishal R. 
Published: August 2023

Abstract:
Pandemics are large-scale epidemics of infectious illness that may cause major economical,
cultural, and political upheaval while also increasing illness and mortality across a huge geographic
area. Evidence shows that pandemics have increased during the last century as a result of
increasing international travel and connectivity, industrialization, agricultural expansion, and higher
destruction of the natural environment. Over time, emerging pathogen strains cause pandemics
that raise suffering, death, and instability in countries. Flu, plague, cholera, HIV, and the current
COVID-19 pandemic caused by a novel coronavirus are just a few of the pathogen outbreaks. Unfortunately,
given the lack of information and instruments to tackle the problem, managing new and
developing infections is frequently challenging. Yet, the use of herbal remedies to treat new and
developing infectious illnesses has received much interest. Until the invention of antibiotics, herbal
plants, their preparations, and extracted phytoconstituents were reported to be efficient in reducing
infectious diseases. Plants contain numerous complex metabolites, such as amino acids, alkaloids,
tannins, flavonoids, terpenoids, and glycosides, that show different therapeutic activities. This review
provides vital and useful information regarding herbal drugs and their effectiveness against
various pathogens that cause major pandemics.
Grammatical Metaphor in Political Discourse in the Central Kurdish Language
Authors: Shekhani Hawsar A. , Jaff Daban Q. 
Published: August 2023

The goal of this work is to examine political discourse in the Central Kurdish language via the prism of Halliday's grammatical metaphor. Political discourse is a common form of public discourse. In the SFG, Halliday identified the ideational and interpersonal grammatical metaphor. This study pertains to the study of Systemic Functional Grammar in that it studies the linguistic metaphors in the political speeches of Mala Bakhtyar and Abul Latif. The two figures are representing two opposing ideologies and they promote different types of religious and political ideologies. The authors utilized a mixed-methods strategy using Halliday's grammatical metaphor to assemble the findings. In the paper, the following research objectives are addressed: The most frequent form of nominalized processes and mood grammatical metaphor in the political public speeches in CK, in the political discourse in Central Kurdish are focused. Second, the expression of reality through ideational grammatical metaphor is investigated. And lastly, the convey of interpersonal meaning in interpersonal grammatical metaphor in the speeches by the political figures is examined. Overall, 133 distinct nominalized processes were identified during the speeches. Four of the six distinct nominalized types of processes were used. The total number of nominalized material process selections is 65, (48.8%) of the total, with verbal process types accounting for 58 events, (43.6%) of the total, and mental process types accounting for only 9 selections, (6.7%). Only one behavioral type was used, accounting for 0.75%. There are no other nominalized process types. And 53 instances of mood grammatical metaphor were drawn. In addition, the authors discovered that both political figures strive to represent their political beliefs using nominalized process types, and the interpersonal mood grammatical metaphor conveys interpersonal meaning.
Smartphone App–Based and Paper-Based Patient-Reported Outcomes Using a Disease-Specific Questionnaire for Dry Eye Disease: Randomized Crossover Equivalence Study
Authors: Nagino Ken , Okumura Yuichi , Akasaki Yasutsugu , Fujio Kenta , Huang Tianxiang , Sung Jaemyoung , Midorikawa-Inomata Akie , Fujimoto Keiichi , Eguchi Atsuko , Hurramhon Shokirova , Yee Alan , Miura Maria , Ohno Mizu , Hirosawa Kunihiko , Morooka Yuki , Murakami Akira , Kobayashi Hiroyuki , Inomata Takenori 
Published: August 2023

Background
Using traditional patient-reported outcomes (PROs), such as paper-based questionnaires, is cumbersome in the era of web-based medical consultation and telemedicine. Electronic PROs may reduce the burden on patients if implemented widely. Considering promising reports of DryEyeRhythm, our in-house mHealth smartphone app for investigating dry eye disease (DED) and the electronic and paper-based Ocular Surface Disease Index (OSDI) should be evaluated and compared to determine their equivalency.

Objective
The purpose of this study is to assess the equivalence between smartphone app–based and paper-based questionnaires for DED.

Methods
This prospective, nonblinded, randomized crossover study enrolled 34 participants between April 2022 and June 2022 at a university hospital in Japan. The participants were allocated randomly into 2 groups in a 1:1 ratio. The paper-app group initially responded to the paper-based Japanese version of the OSDI (J-OSDI), followed by the app-based J-OSDI. The app-paper group responded to similar questionnaires but in reverse order. We performed an equivalence test based on minimal clinically important differences to assess the equivalence of the J-OSDI total scores between the 2 platforms (paper-based vs app-based). A 95% CI of the mean difference between the J-OSDI total scores within the ±7.0 range between the 2 platforms indicated equivalence. The internal consistency and agreement of the app-based J-OSDI were assessed with Cronbach α coefficients and intraclass correlation coefficient values.

Results
A total of 33 participants were included in this study. The total scores for the app- and paper-based J-OSDI indicated satisfactory equivalence per our study definition (mean difference 1.8, 95% CI –1.4 to 5.0). Moreover, the app-based J-OSDI total score demonstrated good internal consistency and agreement (Cronbach α=.958; intraclass correlation=0.919; 95% CI 0.842 to 0.959) and was significantly correlated with its paper-based counterpart (Pearson correlation=0.932, P<.001).

Conclusions
This study demonstrated the equivalence of PROs between the app- and paper-based J-OSDI. Implementing the app-based J-OSDI in various scenarios, including telehealth, may have implications for the early diagnosis of DED and longitudinal monitoring of PROs.
PENGARUH RASIO JAHE DAN GULA AREN TERHADAP SIFAT FISIKOKIMIA DAN SENSORIS JAHE INSTAN
Authors: Syamsul Wawan , Alam Nur , Priyantono Eko 
Published: August 2023

Tujuan dari penelitian ini ialah untuk mendapatkan rasio terbaik (jahe dan gula aren) terhadap karakteristik fisikokimia dan sensoris minuman jahe instan. Penelitian ini dilaksanakan di Laboratorium Agroindustri, Fakultas Pertanian Universitas Tadulako dan Laboratorium Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Tadulako. Penelitian ini menggunakan Rancangan Acak Lengkap satu faktor yang diterapkan untuk analisis sifat-sifat fisik dan kimia sedangkan Rancangan Acak Kelompok digunakan untuk analisis sifat sensoris jahe instan. Dengan formulasi perlakuan jahe dan gula aren, A(150:350g/g), B(200:300g/g), C(250:250g/g), D(300:200g/g), E(350:150g/g). Berdasarkan hasil penelitian dapat disimpulkan bahwa, rasio jahe dan gula aren (150:350g/g) memberikan karakteristik fisikokimia dan sensoris terbaik terhadap minuman jahe instan dengan nilai rendemen 37,37%, kadar air 3,37%, pH 6,08, waktu larut, 30,56 menit, total padatan terlarut 18,38%, skor rasa 5,65, skor aroma 5,60, skor warna 5,70 dan kesukaan 5,65.
Third-Party Source Switches: Objective Valuation or Fair Value Opinion Shopping?
Authors: Koo Minjae , Sivaramakrishnan Konduru , Zhao Yuping 
Published: August 2023

ABSTRACT
Fair value estimates from external third-party sources are generally considered more reliable than internal estimates based on managerial inputs. However, even externally sourced estimates are subject to managerial opportunism, because firms can switch from one external source to another. In the context of life insurance companies that mostly rely on external sources, we posit that such source switches could be driven by managerial incentive either to faithfully report fair values (objective valuation) or to inflate estimates to avoid OTTI (opinion shopping). Our results support both motives. In instances in which the two incentives yield conflicting predictions for source switching, we find the opinion-shopping motive dominates. We also find that switches that increase fair value estimates are associated with a reduced OTTI likelihood and magnitude, especially for high-impairment-risk securities. On balance, our evidence suggests that opportunism with respect to source switching can compromise the reliability of externally sourced fair value estimates.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: G22; M41.
Hubungan kemampuan komunikasi interpersonal dengan keharmonisan keluarga
Authors: Fitriza Dwi , Taufik Taufik 
Published: August 2023

Komunikasi interpersonal merupakan faktor yang mempengaruhi keharmonisan suami istri dalam rumah tangga. Namun, tidak selalu komunikasi interpersonal antara pasangan suami istri selalu berjalan dengan baik, seringkali akibat komunikasi yang tidak berjalan baik menyebabkan kesalahpahaman bahkan perceraian dalam keluarga. Penelitian ini menguji hubungan komunikasi interpersonal dengan keharmonisan dalam keluarga. Jenis penelitian ini termasuk penelitian kuantitatif korelasional. Populasi penelitian adalah pasangan suami istri di kecamatan Siulak Mukai, Kabupaten Kerinci dengan teknik penarikan sampel bertujuan (Purposive sampling) sebanyak 70 orang atau 35 pasangan.Berdasarkan hasil penelitian terdapat hubungan yang signifikan antara komunikasi interpersonal dengan keharmonisan dalam keluarga.