bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluid Circulation Effects on Torque and Drag Results, Modeling, and Validation
Authors: Mahjoub M. , Dao N.-H , Summersgill M. , Menand S. 
Published: June 2023

Summary
The hydraulic effects on torque and drag modeling have been thoroughly studied in the past, yet their interpretation still causes a lot of misunderstandings and confusion. Historical models disregard the circulation effects and focus on the fluid mass by employing buoyancy forces based on the Archimedes principle. On the other hand, the reference model including the fluid circulation effects, introduced by R. F. Mitchell in the 1990s, consists in computing the forces due to internal and external fluids along the drillstring. The first type of model (called the Archimedes method) directly produces an effective tension, while the second one (generally called the pressure area method) produces a true tension that must be further transformed to obtain the effective tension. These different forms of tensions add even more confusion. By returning to the basic equations of the fluid effects on the drillstring, an equivalency between Archimedes and pressure area models has been found for the case with no circulation. Furthermore, with the same principle, an Archimedes-like model is deduced for the case of fluid circulation, where the effects of fluid pressures, frictions, and flows could be more easily interpreted. These two hydraulic models, after implementation in a true stiff-string 3D model, enable them to fairly compare the two approaches in terms of forces applied on the structure. The comparison of this Archimedes formulation with pressure area model gave sensibly the same results for various scenarios, proving the equivalency of the two approaches even with the case of circulating fluid. In addition to the model-to-model comparisons, torque and drag results are compared to field experiments at different depths. The flow rate was varied while reciprocating the drillstring up and down, and the hookload was recorded for each flow rate and each tripping direction. The model-to-data comparisons showed a good agreement between the theoretical results and experimental data. An advanced Archimedes method with all fluid circulation effects has been developed. By tackling the problem of circulating fluid in the drillstring using two different approaches and proving their equivalency, a better understanding of the hydraulic effects can be achieved, which in terms can help settle the possible debates and confusion that might arise by drilling engineers.
Effect of Baduanjin on pulmonary rehabilitation outcomes in patients with moderate chronic obstructive pulmonary disease: a multi-center randomized controlled trial
Authors: Chen Xuan , Fu Cuiping , Wang Xiongbiao , Sun Meng , Shi Jindong , Zhang Wei , Li Shanqun 
Published: June 2023

Abstract
Background: Effect of Baduanjin, as a traditional Chinese mindful movement, on patients with moderate chronic obstructive pulmonary disease (COPD), was still unknown. The aim of our study was to evaluate its efficiency on pulmonary function and exercise capacity in moderate COPD patients.
Method: A multi-center randomized controlled trial about moderate COPD patients were collected from ten hospitals in Shanghai. Tri-Ball® Respiratory training was used as the control PR intervention in this trail to evaluate the efficiency of Baduanjin. After signing informed consent, all participants recruited were followed a two-week run-in period. Participants were randomly assigned into four groups, namely Baduanjin alone, Tri-Ball® Respiratory training alone, Baduanjin combined with respiratory training, and the control group. Each group lasted for 12 weeks. The outcome assessments were conducted at four time points, namely at the 4th week and 8th week during the intervention, at the end of 12-week pulmonary rehabilitation program, and at the end of the 24-week follow up.
Result: A total of 240 participants were recruited in this prospective randomized controlled trail. After exclusion, 217 moderate COPD patients were analyzed in this study. After 12 weeks, Baduanjin traing showed improvement in pulmonary function (percent of FEV1 predicted, FEV1 pred%) and dyspnea (modified British medical research council questionnaire, mMRC scale), exercise capacity (six-minute walk distance, 6MWD), and therapeutic efficiency (COPD assessment test, CAT) in moderate COPD patients. Banduanjin presented better PR results than the control. Besides, combining Baduanjin with additional inspiratory muscle training presented better PR result than banduanjin or inrespiratory muscle exercise alone. The positive effect on parameter of pulmonary function, exercise capacity and therapeutic efficiency were perceived by subjects and continued to maintain after 24-week follow up.
Conclusion: The results of this trial indicated that traditional Baduanjin exercise could prevent COPD lung function deterioration, and provide a simple, and daily pulmonary rehabilitation measure for the patients with moderate COPD.
Trial Registration: The study protocol has been registered with the Clinical Trial Registry (NCT03892629).
Impact of Blood Alpha-tocopherol Levels on Oocyte and Embryo Quality in Women Undergoing IVF/ICSI Treatment: A Cross-sectional Study
Authors: Faisal Raghad , Alhalabi Marwan , Alquobaili Faizeh 
Published: June 2023

Abstract
Background: Evaluation of oocyte quality is one of the most important goals of embryologists in assisted reproductive technologies, due to its importance in successful fertilization and embryonic development. Females undergoing in vitro fertilization are exposed to massive systemic oxidative stress due to the ovarian stimulation protocols used, which negatively affects oocyte maturation and embryonic development. Vitamin E is one of the most important exogenous antioxidants purported to defend against oxidative stress by modifying free radical electrons, and therefore it is necessary to investigate the effect of its blood levels on oocyte maturation and the embryo quality in women undergoing in vitro fertilization treatment.
Methods: An observational, cross-sectional study was conducted on 60 females undergoing IVF treatment by pituitary down-regulation with GnRH agonist. Alpha-tocopherol levels in the serum and the follicular fluid were determined using an HPLC kit for vitamin E (RECIPE, Germany). The maturity of the oocyte nucleus as well as the development of the resulting embryos after sperm injection are evaluated by the in vitro fertilization specialist. Grade Ι embryos resulting from the injection of high-quality oocytes (MΠ oocytes) are what the doctor seeks to obtain to return these embryos to the uterus. We investigated the relationship between serum alpha-tocopherol levels with the percentage of MΠ oocytes and Grade Ι embryos using Statistical Package for Social Sciences version 23, and a chi-square test was adopted to study differences in the distribution rates of the types of oocytes and embryos at different levels of vitamin E in the blood.
Results: According to the blood vitamin E levels, a significant difference (p= 0.001) was found between the percentages of both MΠ oocytes and grade Ι embryos. The highest percentages were for levels (10-<15), followed by levels (5-<10), while the lowest percentages were seen for levels (15-20) mg/l of vitamin E in the blood for both, which were 68 and 62, 17 and 20, 15 and 17%, respectively.
Conclusion: The highest ratio of both mature oocytes (MΠ) and high-quality embryos (Grade I) can be achieved at blood levels of alpha-tocopherol (10-<15) mg/l in women undergoing IVF-ICSI.
Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning
Authors: Hu Xiaodi , Sun Mingwei , Chen Qian , Zhao Yixia , Liang Na , Wang Siyuan , Yin Pengbin , Yang Yuanping , Lam Sin Man , Zhang Qianying , Tudiyusufu Alimujiang , Gu Yingying , Wan Xin , Chen Meihong , Li Hu , Zhang Xiaofei , Shui Guanghou , Fu Suneng , Zhang Licheng , Tang Peifu , Wong Catherine C. L. , Zhang Yong , Zhu Dahai 
Published: June 2023

Abstract
Skeletal muscle is the largest metabolic and endocrine organ. It secretes various peptides that contribute to regulating body energy homeostasis by communicating with other metabolic organs. However, it is unknown whether muscle-secreted lipids exert a similar function. Myodis specifically expressed in skeletal muscle. Here, we report that genetic deletion of Myod in mice enhanced the oxidative metabolism of muscle and, intriguingly, rendered the mice resistant to HFD-induced obesity. By performing lipidomic analysis in muscle-conditioned medium and serum, we identified 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) as a muscle-released lipid that is responsible for MyoD-orchestrated body energy homeostasis in Myod KO mice. Functionally, the administration of DLPC significantly ameliorated HFD-induced obesity in mice. Mechanistically, DLPC was found to induce white adipose browning via lipid peroxidation-mediated p38 signaling in mice. Collectively, our findings uncover DLPC as the first muscle-derived lipokine and suggest that it might have clinical potential for treating obesity in humans.
Mutation-independent cystic fibrosis treatment by opening calcium-activated chloride channel with a novel GPR39 agonist, DS-1039
Authors: Muneoka Satoshi , Nakai Daisuke , Haruyama Munetada , Enomoto Kei , Hama Yasuhiro , Kanki Satomi , Terashima Hideki , Egashira Shiori , Kamei Reiko , Maeda Yuko , Inomata Norio , Tomimori Yoshiaki 
Published: June 2023

Abstract
Cystic fibrosis (CF) is a life-limiting genetic disease characterized by decreased chloride and water secretion and caused by loss-of-function mutations in CF transmembrane conductance regulator (CFTR), an epithelial chloride channel. Here, we report DS-1039, an orally active GPR39 agonist, as a novel pharmacological agent to rescue CFTR dysfunction by activating calcium-activated chloride channel (CaCC). DS-1039 induced sustained chloride secretion and fluid transfer in primary bronchial epithelial cells from CF patients. DS-1039 activity was comparable to that of ivacaftor and lumacaftor in mutations with indications for these CFTR modulators, and even observed in class I mutations without approved CFTR modulators. DS-1039 oral administration to mice induced significant tear secretion. Combined with human pharmacokinetics (PK) projection and PK/pharmacodynamics relationship analysis, it was suggested that GPR39 agonists could induce fluid transfer in humans at practical doses. These findings highlight DS-1039 as a promising novel oral agent for CF treatment independent of CFTR mutation.
Association of Glycemic Variability and Time in Range with Lipid Profile in Type 1 Diabetes
Authors: Castelo Mariana Isabel Salsa , Neves Celestino , Neves João Sérgio , Carvalho Davide 
Published: June 2023

Abstract
Purpose
Hyperglycemia is associated with abnormalities of lipoproteins. The aim of this study was to analyze, in patients with Type 1 Diabetes (T1D), the association of glycemic control with lipid profile, focusing on glycemic variability and time in range obtained from Continuous Glucose Monitoring (CGM).
Methods
We performed a retrospective cohort in patients with T1D. We analyzed clinical parameters, HbA1c, CGM and lipid profile in two moments 6 to 18 months apart. We evaluated the association of HbA1c and CGM metrics with lipid profile in cross-sectional (n = 242) and longitudinal (n = 90) analyses.
Results
The mean age of the study population was 36.6 ± 12.6 years, 51.7% were male, and the mean diabetes duration was 16.8 ± 10.3 years. In the cross-sectional analysis, higher HbA1c, higher glucose management indicator (GMI), higher time above range and lower time in range were associated with higher triglyceride levels. In the longitudinal analysis, an increase in time below range was associated with a decrease of HDL cholesterol. In both analyses, an increase in the coefficient of variability (CV) was associated with a significant decrease of HDL cholesterol. HbA1c and CGM were not associated with total cholesterol or LDL cholesterol.
Conclusions
We observed a negative association between CV and HDL cholesterol levels and a positive association between hyperglycemia metrics and triglyceride levels. These findings suggest that CGM parameters may be a helpful tool to guide the improvement of both glycemic control and lipid profile in T1D.
Does Yoga impact during Pregnancy: Systematic Review
Authors: Pais Maria , Pai Muralidhar V , Shashidar Dishashree Belathur 
Published: June 2023

Abstract
Background: Pregnancy-related stress will lead to many complications and it will affect the health of pregnant women. Many complementary therapies have a positive effect on the health of the mother and unborn child. RCTs were utilized to investigate the advantages of yoga for expectant mothers and their unborn children. High levels of stress especially between 25 to 28 weeks of pregnancy may also be connected to autism in children.
Aim The aim of this systematic review was to investigate all Randomized Control trials [RCT] that have a potential impact of yoga on pregnancy-related stress and pregnancy outcome.
MethodsA systematic search in PubMed, Web of Science, EMBASE, and CINAHL databases was undertaken from 2012 to 2022. Randomized Control Trial studies on pregnant women with yoga intervention especially in the second trimester, reporting either pregnancy or neonatal outcomes were included.
Results: The search resulted in potentially relevant studies; 16 were included. The majority of research studies found that pregnant women who practiced yoga had lower stress levels (p<0.001) as well as normal platelet counts and pregnancy outcomes (p<0.001), and had a positive impact of yoga during pregnancy.
Conclusion: In this systematic review shows that a prenatal yoga program gives pregnancy benefits well as well-planned labour and birth outcomes. Improvements in psychological, physical, and biological health of mother and child.
The application of virtual reality exposure versus relaxation training in music performance anxiety: a randomized controlled study
Authors: Bellinger Daniel , Wehrmann Kristin , Rohde Anna , Schuppert Maria , Störk Stefan , Flohr-Jost Michael , Gall Dominik , Pauli Paul , Deckert Jürgen , Herrmann Martin , Erhardt-Lehmann Angelika 
Published: June 2023

Abstract
Background
Performance anxiety is the most frequently reported anxiety disorder among professional musicians. Typical symptoms are - on a physical level - the consequences of an increase in sympathetic tone with cardiac stress, such as acceleration of heartbeat, increase in blood pressure, increased respiratory rate and tremor up to nausea or flush reactions. These symptoms can cause emotional distress, a reduced musical and artistical performance up to an impaired functioning. While anxiety disorders are preferably treated using cognitive-behavioral therapy with exposure, this approach is rather difficult for treating music performance anxiety since the presence of a public or professional jury is required and not easily available. The use of virtual reality could therefore display an alternative. So far, no therapy studies on music performance anxiety applying virtual reality exposure therapy have investigated the therapy outcome including cardiovascular changes as outcome parameters.
Methods
This mono-center, prospective, randomized and controlled clinical trial has a pre-post design with a follow-up period of 6 months. 46 professional and semi-professional musicians will be recruited and allocated randomly to an VR exposure group or a control group receiving progressive muscle relaxation training. Both groups will be treated over 4 single sessions. Music performance anxiety will be diagnosed based on a clinical interview using ICD-10 and DSM-5 criteria for specific phobia or social anxiety. A behavioral assessment test is conducted three times (pre, post, follow-up) in VR group through an audition in a concert hall. Primary outcomes are the changes in music performance anxiety measured by the German Bühnenangstfragebogen and the cardiovascular reactivity reflected by heart rate variability (HRV). Secondary outcomes are changes in blood pressure, stress parameters such as cortisol in the blood and saliva, neuropeptides, and DNA-methylation.
Discussion
The trial investigates the effect of VR exposure in musicians with performance anxiety compared to a relaxation technique on anxiety symptoms and corresponding cardiovascular parameters. We expect a reduction of anxiety but also a consecutive improvement of HRV with cardiovascular protective effects.
Trial registration
This study was registered on clinicaltrials.gov. (ClinicalTrials.gov Number: NCT05735860)
Association between long working hours and suboptimal health status on primary care physicians：a cross-sectional survey from primary care institutions in China
Authors: Huang Rong , Huang Yuankai , Xi Xiaoyu , Liu Jiayuan 
Published: June 2023

Abstract
Background
Primary care physicians in China generally work overtime and are exposed to higher incidence of suboptimal health status (SHS). However, the quantitative relationship between long working hours and SHS on primary care physicians remains unclear. This study aims to analyze the association of long working hours and SHS in China.
Methods
This nationwide cross-sectional survey was conducted with a randomized stratified sampling strategy. The Sub-Health Measurement Scale V1.0 was applied to measure SHS and logit regression was further adopted to explore association between long working hours and SHS.
Results
A total of 1227 questionnaires from 545 primary care institutions in China returned, of which 687 were valid with 56% effective rate. All the surveyed primary care physicians reported to work over 10 hours in at least one day per week. Compared to 6–7 days/week working over 10h, the risk of global SHS in the physicians who worked over 10 hours 4–5 days/week, 2–3 days/week and 1–2 days/week were increase with OR = 2.11([95%CI [1.11 ~ 4.01],P = 0.023),OR = 2.08 (95%CI [1.13 ~ 3.81], P = 0.018),OR = 1.86 (95%CI[1.03 ~ 3.37], P = 0.039), respectively. Compared to 6–7 days/week working over 10h, the risk of social SHS in the physicians who worked over 10 hours 4–5 days/week, 2–3 days/week and 1–2 days/week were increase with OR = 2.63([95%CI [1.35 ~ 5.14], P = 0.005),OR = 1.9 (95%CI [1.04 ~ 3.49], P = 0.037),OR = 1.92 (95%CI [1.06 ~ 3.48], P = 0.031), respectively.
Conclusion
Different from previous studies, this study surprisingly found that higher frequency of long working hours was related to lower incidence of global SHS and social SHS among primary care physicians in China, which indicated that long working hours not a risk factor for SHS and probably since hard-working increases Chinese physicians’ self-social values further reduces the incidence of SHS.
CblC Deficiency is the Cause of Persistent Proteinuria in a Young Female Ten Years After the Diagnosis of Atypical Nephropathy: A Case Report
Authors: Yang Min , Xin Ying , Du Yue 
Published: June 2023

Abstract
Background: Cobalamin C (cblC) deficiency is the most common inborn error of cobalamin metabolism. It is caused by pathogenic variants in the MMACHC gene with varying clinical features. However, proteinuria as the primary manifestation is exceedingly rare and renal biopsy demonstrating primary glomerular pathology also is infrequent. Here we report a pediatric patient with persistent proteinuria for ten years who was ultimately diagnosed as cblC deficiency and the pathological features suggestive of mesangial proliferative glomerulonephritis. Clinical and biochemical data, as well as detailed pathological findings at diagnosis and after 10 years, were also provided.
Case presentation: A 13-year-old girl with persistent proteinuria was diagnosed with atypical nephropathy for more than ten years prior. Hyperhomocysteinemia was occasionally observed for megaloblastic anemia. Further comprehensive genetic analyses of peripheral blood-derived DNA demonstrated heterozygous variants of methylmalonic aciduria type C and homocystinuria (MMACHC). CblC deficiency was finally found to be the cause of kidney dysfunction. Hydroxocobalamin, betaine, and L-carnitine were administered. The patient achieved resolution of the MMA and homocysteinemia, but she still had persistent proteinuria. The repeated biopsy showed developed to chronicity, which indicated a poor prognosis.
Conclusions: CblC deficiency should be suspected in the event of proteinuria with or without neurological symptoms. Glomerulopathy is another histopathological pattern of renal injury that is associated with cblC deficiency. The clinical manifestations are atypical, including proteinuria, hematuria and hypertension. Early detection and treatment as well as regular follow-up are important factors for a favorable prognosis
Quality of life in patients with Stiff-Person Syndrome: Evaluation congruent with patient values using the schedule-direct weighting method
Authors: Kobayashi Chiemi , Makihara Yukiko , Nishida Yusuke 
Published: June 2023

Abstract
The health-related quality of life (HRQoL) of patients with chronic progressive disease is low; however, various compensation mechanisms (medical, informal support, formal support, and environmental mechanisms) can improve and restore quality of life (QoL) even in cases of severe physical disability. In this study, we evaluate the QoL according to patient value by individual QoL assessment and identify the determinants of QoL of patients with Stiff-Person Syndrome (SPS) to consider specific support measures. As of December 2020, 13 patients diagnosed with SPS participated in a mixed study that included questionnaires and semi-structured interviews. The main positive factors cited by patients included ‘family support’ and ‘parental care’, whereas negative factors included ‘physical symptoms’ and ‘relationship with doctors’. Comparing SPS with other diseases revealed ‘parental care’ as a unique determinant of QoL in patients with SPS. ‘Parental care’ was identified as the most important area with the highest weight but low satisfaction; hence, in each case, support is needed to ensure that the patient’s caregiver was satisfactory. Additionally, ‘physical symptoms’ was the strongest negative area and can be alleviated by medical assistance. Furthermore, rehabilitation should address the relief of pain caused by muscle spasms and rigidity.
Calcified apoptotic bodies from PROCR+ fibroblasts initiate the tendon calcification at the early stages of heterotopic ossification
Authors: Yan Jian-fei , Gao Bo , Lu Weicheng , Qin Wenpin , Han Xiaoxiao , Wang Chen-yu , Liu Ying-Ying , Li Tao , Guo Zhenxin , Ye Tao , Wan Qian-qian , Xu Hao-qing , Kang Junjun , Lu Naining , Gao Chang-he , Qin Zi-xuan , Niu Li-na , Zou Weiguo , Jiao Kai 
Published: June 2023

AbstractHeterotopic ossification (HO) comprises the abnormal formation of ectopic bone in extraskeletal soft tissue. The factors that initiate HO remain elusive. Herein, we found that calcified apoptotic bodies (CABs), which are secreted by PROCR+fibroblasts in the early stage of HO, lead to increased stiffness of the extracellular matrix. Specifically, single-cell transcriptome analyses of different stages of HO revealed a PROCR+fibroblast population that released CABs in the early stage of HO. CAB aggregation produced calcified nodules with high concentrations of calcium and phosphate, similar to those in calcified tendons. Annexin channels mediate calcium influx into CABs, which absorb to collagen I via electrostatic interaction. Functional inhibition of CABs significantly decreased the early stage microcalcification and inhibited HO of Achilles tendons. Thus, we revealed a pathological mechanism of HO initiation and identified CABs from PROCR+fibroblasts as the initiating factor of local microcalcification, creating an osteogenic microenvironment for HO.