bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low rates of radiographic progression associated with clinical efficacy following up to 2 years of treatment with guselkumab: results from a phase 3, randomised, double-blind, placebo-controlled study of biologic-naïve patients with active psoriatic arthritis
Authors: Gottlieb Alice B , McInnes Iain B , Rahman Proton , Kollmeier Alexa P , Xu Xie L , Jiang Yusang , Sheng Shihong , Shawi May , Chakravarty Soumya D , Lavie Frederic , Mease Philip J 
Published: February 2023

ObjectiveEvaluate relationship between radiographic progression and clinical outcomes in post hoc analyses of patients with psoriatic arthritis (PsA) receiving up to 2 years of guselkumab therapy in the phase 3, placebo-controlled, randomised trial, DISCOVER-2.MethodsBiologic-naïve adults with active PsA (≥5 swollen joints /≥5 tender joints ; C reactive protein ≥0.6 mg/dL) were randomised to guselkumab 100 mg every 4 weeks (Q4W); guselkumab 100 mg at week 0, week 4, then every 8 weeks (Q8W); or placebo→guselkumab 100 mg Q4W (week 24). Radiographs (hands/feet) at week 0, week 24, week 52 and week 100 were scored via PsA-modified van der Heijde-Sharp (vdH-S) methodology. In these post hoc analyses, mean changes in vdH-S scores were summarised according to achievement of American College of Rheumatology 20/50/70 response; low disease activity (LDA) defined by Disease Activity in Psoriatic Arthritis (DAPSA) ≤14 or Psoriatic ArthritiS Disease Activity Score (PASDAS) ≤3.2, or minimal/very low disease activity (MDA/VLDA); and normalised physical function (Health Assessment Questionnaire-Disability Index (HAQ-DI) ≤0.5). Response rates for achieving MDA/VLDA and each component were determined among patients with and without radiographic progression (change in total vdH-S score >0.5). No formal hypothesis testing was performed.Results664 of 739 treated patients in DISCOVER-2 continued study treatment at week 52 and were included in these analyses. Mean changes in vdH-S scores from weeks 0 to 100 among all patients in the Q4W and Q8W groups were 1.7 and 1.5, respectively. Among all guselkumab-randomised patients, those who achieved ACR20/50/70, DAPSA LDA, PASDAS LDA, MDA, VLDA and HAQ-DI ≤0.5 (normalised physical function) had smaller mean changes in vdH-S scores than did non-responders at week 52 (0.2–1.2 vs 1.7–4.1) and week 100 (0.3–1.2 vs 2.0–4.6). Relative to patients with radiographic progression, those without progression were more likely to achieve the MDA criteria related to swollen and tender joint counts, patient-reported pain and global assessment, and normalised physical function through week 100.ConclusionIn these post hoc analyses, the achievement of low levels of disease activity, including MDA, was associated with diminished rates of radiographic progression observed in patients receiving up to 2 years of guselkumab. Radiographic non-progressors were more likely to achieve patient-reported MDA criteria of minimal pain and normalised physical function compared with radiographic non-responders.Trial registration numberNCT03158285.
Graph Clustering: a graph-based clustering algorithm for the electromagnetic calorimeter in LHCb
Authors: Canudas Núria Valls , Gómez Míriam Calvo , Vilasís-Cardona Xavier , Ribé Elisabet Golobardes 
Published: February 2023

AbstractThe recent upgrade of the LHCb experiment pushes data processing rates up to 40 Tbit/s. Out of the whole reconstruction sequence, one of the most time consuming algorithms is the calorimeter data reconstruction. It aims at performing a clustering of the readout cells from the detector that belong to the same particle in order to measure its energy and position. This article presents a new algorithm for the calorimeter data reconstruction that makes use of graph data structures to optimise the clustering process, that will be denoted Graph Clustering. It outperforms the previously used method by $$65.4\%$$

65.4
%

in terms of computational time on average, with an equivalent efficiency and resolution. The implementation of the Graph Clustering method is detailed in this article, together with its performance results inside the LHCb framework using simulation data.
d
‐Dimer Level After Endovascular Treatment Can Help Predict Outcome of Acute Ischemic Stroke
Authors: Nam Hyo Suk , Kim Young Dae , Yoo Joonsang , Park Hyungjong , Kim Byung Moon , Bang Oh Young , Kim Hyeon Chang , Han Euna , Kim Dong Joon , Lee Il Hyung , Lee Hyungwoo , Choi Jin Kyo , Lee Kyung‐Yul , Lee Hye Sun , Shin Dong Hoon , Choi Hye‐Yeon , Sohn Sung‐Il , Hong Jeong‐Ho , Lee Jong Yun , Baek Jang‐Hyun , Kim Gyu Sik , Seo Woo‐Keun , Chung Jong‐Won , Kim Seo Hyun , Song Tae‐Jin , Han Sang Won , Park Joong Hyun , Kim Jinkwon , Jung Yo Han , Cho Han‐Jin , Ahn Seong Hwan , Seo Kwon‐Duk , Lee Kee Ook , Song Jaewoo , Heo Ji Hoe 
Published: February 2023

Background

d
‐Dimer level is a marker of hypercoagulability, which is associated with thrombus formation and resolution. We investigated the value of
d
‐dimer levels in predicting outcomes of acute ischemic stroke in patients who underwent endovascular treatment (EVT).

Methods

We analyzed data of patients who underwent only EVT from the SECRET (Selection Criteria in Endovascular Thrombectomy and Thrombolytic Therapy) registry.
d
‐Dimer levels were routinely measured in 10 of 15 participating hospitals. Patients were grouped into tertiles (tertile 1, tertile 2, and tertile 3) according to
d
‐dimer levels (lowest, moderate, and highest, respectively). We compared serial scores on the National Institutes of Health Stroke Scale at baseline, on day 1 of hospitalization, and at discharge; functional outcome 3 months after EVT; and rate of mortality within 6 months after EVT.

Results

In the 170 patients, the median
d
‐dimer level was 477 ng/mL (interquartile range, 249–988 ng/mL). In tertile 3, the National Institutes of Health Stroke Scale score was higher at discharge than on day 1 of hospitalization. Poor outcome 3 months after EVT (modified Rankin Scale score, ≥3) was more common with high
d
‐dimer levels (26.3% of tertile 1, 57.1% of tertile 2, and 76.4% of tertile 3;
P
<0.001). Multivariable analysis showed that a high
d
‐dimer level was independently associated with poor outcome 3 months after EVT (odds ratio [OR], 4.399 [95% CI, 1.594–12.135]). Kaplan–Meier survival analysis showed that a high
d
‐dimer level was independently associated with death within 6 months after EVT (OR, 5.441 [95% CI, 1.560–18.978]; log‐rank test,
P
<0.001). The
d
‐dimer effect showed no heterogeneity across the subgroups for poor outcome 3 months after EVT or death within 6 months after EVT. The direction of effect was unfavorable for tertile 3 across all demographic strata.

Conclusions

High plasma
d
‐dimer levels were predictive of early neurologic worsening, poor functional outcome 3 months after EVT, and death within 6 months after EVT.

Registration

URL:
http://www.clinicaltrials.gov
; Unique identifier: NCT02964052.
Early Osteoarthritis Questionnaire (EOAQ): a tool to assess knee osteoarthritis at initial stage
Authors: Migliore Alberto , Alekseeva Liudmila , Avasthi Sachin R. , Bannuru Raveendhara R. , Chevalier Xavier , Conrozier Thierry , Crimaldi Sergio , de Campos Gustavo C. , Diracoglu Demirhan , Gigliucci Gianfranco , Herrero-Beaumont Gabriel , Iolascon Giovanni , Ionescu Ruxandra , Jerosch Jörg , Lains Jorge , Maheu Emmanuel , Makri Souz , Martusevich Natalia , Matucci-Cerinic Marco , Pavelka Karen , Petrella Robert J. , Raman Raghu , Tarantino Umberto 
Published: February 2023

Background: Early stage of osteoarthritis (OA) is characterized by joint stiffness and pain as well as by subclinical structural changes that may affect cartilage, synovium, and bone. At the moment, the lack of a validated definition of early osteoarthritis (EOA) does not allow to make an early diagnosis and adopt a therapeutic strategy to slow disease progression. Also, no questionnaires are available to evaluate the early stage, and therefore this remains an unmet need. Objective: Therefore, the purpose of the technical experts panel (TEP) of ‘International Symposium of intra-articular treatment’ (ISIAT) was to create a specific questionnaire to evaluate and monitor the follow-up and clinical progress of patients affected by early knee OA. Design: The items for the Early Osteoarthritis Questionnaire (EOAQ) were identified according to the following steps: items generation, items reduction, and pre-test submission. Methods: During the first step, literature has been reviewed and a comprehensive list of items about pain and function in knee EOA was drafted. Then, during the ISIAT (5th edition 2019), the draft has been discussed by the board, which reformulated, deleted, or subdivided some of the items. After the ISIAT symposium, the draft was submitted to 24 subjects affected by knee OA. A score based on the importance and the frequency was created and the items with a score ⩾0.75 were selected. After intermediate evaluation made by a sample of patients, the second and final version of the questionnaire EOAQ was submitted to the whole board for final analysis and acceptance in a second meeting (29 January 2021). Results: After an exhaustive elaboration, the final version of the questionnaire contains two domains (Clinical Features and Patients Reported Outcome) with respectively 2 and 9 questions, for a total of 11 questions. Questions mainly explored the fields of early symptoms and patients reported outcomes. Marginally, the need of the symptoms treatment and the use of painkillers were investigated. Conclusions: Adoption of diagnostic criteria of early OA is strongly encouraged and a specific questionnaire for the whole management of the clinical features and patients’ outcome might really improve the evolution of OA in the early stages of the disease, when the treatment is expected to be more effective.
For-profit versus non-profit cybersecurity posture: breach types and locations in healthcare organisations
Authors: Ignatovski Martin 
Published: February 2023

Background The implementation of emerging technologies has resulted in an increase of data breaches in healthcare organisations, especially during the COVID-19 pandemic. Health information and cybersecurity managers need to understand if, and to what extent, breach types and locations are associated with their organisation’s business type. Objective To investigate if breach type and breach location are associated with business type, and if so, investigate how these factors affect information systems and protected health information in for-profit versus non-profit organisations. Method The quantitative study was performed using chi-square tests for association and post-hoc comparison of column proportions analysis on an archival data set of reported healthcare data breaches from 2020 to 2022. Data from the Department of Health and Human Services website was retrieved and each organisation classified as for-profit or non-profit. Results For-profit organisations experienced a significantly higher number of breaches due to theft, and non-profit organisations experienced a significantly higher number of breaches due to unauthorised access. Furthermore, the number of breaches that occurred on laptops and paper/films was significantly higher in for-profit organisations. Conclusion While the threat level of hacking techniques is the same in for-profit and non-profit organisations, certain breach types are more likely to occur within specific breach locations based on the organisation’s business type. To protect the privacy and security of medical information, health information and cybersecurity managers need to align with industry-leading frameworks and controls to prevent specific breach types that occur in specific locations within their environments.
Successful long-term outcome with radiation and prednisolone following a postoperative feline vertebral angiomatosis relapse
Authors: Leonardi Hugo , Poirier Valérie , Iverson Melanie , Samarani Francesca 
Published: February 2023

Case summary A 1-year-old male castrated domestic shorthair cat was presented to the Ontario Veterinary College for a week-long history of lethargy and reluctance to walk. CT and MRI revealed a monostotic T5 compressive vertebral lesion that was excised in surgery via pediculectomy. Histology and advanced imaging were consistent with feline vertebral angiomatosis. The cat relapsed both clinically and on CT 2 months postoperatively and was therefore treated with an intensity-modulated radiation therapy protocol (45 Gy over 18 fractions) and tapering doses of prednisolone. On follow-up CT and MRI at 3 and 6 months post-radiation, the lesion was static and then improved at 19 months post-radiation, with no signs of pain reported. Relevance and novel information To our knowledge, this is the first described case of a postoperative relapse of feline vertebral angiomatosis treated with radiation therapy and prednisolone with a successful long-term follow-up.
Peripheral metabolism of lipoprotein-amyloid beta as a risk factor for Alzheimer’s disease: potential interactive effects of APOE genotype with dietary fats
Authors: D’Alonzo Zachary J. , Lam Virginie , Takechi Ryu , Nesbit Michael , Vaccarezza Mauro , Mamo John C. L. 
Published: February 2023

AbstractAlzheimer’s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by brain parenchymal abundance of amyloid-beta (Aβ) and the accumulation of lipofuscin material that is rich in neutral lipids. However, the mechanisms for aetiology of AD are presently not established. There is increasing evidence that metabolism of lipoprotein-Aβ in blood is associated with AD risk, via a microvascular axis that features breakdown of the blood-brain barrier, extravasation of lipoprotein-Aβ to brain parenchyme and thereafter heightened inflammation. A peripheral lipoprotein-Aβ/capillary axis for AD reconciles alternate hypotheses for a vascular, or amyloid origin of disease, with amyloidosis being probably consequential. Dietary fats may markedly influence the plasma abundance of lipoprotein-Aβ and by extension AD risk. Similarly, apolipoprotein E (Apo E) serves as the primary ligand by which lipoproteins are cleared from plasma via high-affinity receptors, for binding to extracellular matrices and thereafter for uptake of lipoprotein-Aβ via resident inflammatory cells. The epsilon APOE ε4 isoform, a major risk factor for AD, is associated with delayed catabolism of lipoproteins and by extension may increase AD risk due to increased exposure to circulating lipoprotein-Aβ and microvascular corruption.
Clinic study on macular epiretinal membrane in patients under the age of 40 years
Authors: Wang Nan , Peng Aohua , Li Shengguo , Ding Chun 
Published: February 2023

Abstract
Background
To describe the risk factors and clinical characteristics of macular epiretinal membrane (MEM) disease in patients up to the age of 40 years and to evaluate the therapeutic effect of IVTA on MEM.

Methods
Clinical records were reviewed and the etiology of each case and the age distribution data were collected in this retrospective, cohort study. The clinical characteristics of MEM and the factors affecting VA were analyzed. Additionally, we contrasted the effects of MEM peeling with and without intravitreal triamcinolone acetonide on visual acuity (VA) and central foveal thickness (CFT).

Results
In young patients, the incidence of partial posterior vitreous detachment (P-PVD) was considerably higher in IMEM than SMEM (P = 0.007). Furthermore, patients with stage 3 MEM had lower BCVA values than patients with stage 4 MEM (P < 0.001). Patients who live in urban had lower BCVA values than patients in rural (P < 0.001). Patients with IS/OS integrity had lower BCVA values than patients without IS/OS integrity (P < 0.001). The BCVA values in patients with IMEM were significantly lower than those of patients with SMEM (P < 0.001). BCVA was associated most commonly with etiology (P = 0.001), followed by region (P = 0.002). All patients had a decrease in logMAR Vas and CFT, but the combination of intraoperative IVTA resulted in a more significant decrease in logMAR Vas (P = 0.007) and CFT (P = 0.046).

Conclusion
In young patients, the incidence of P-PVD was significantly higher in IMEM cases than in SMEM cases. The region, MEM stage, IS/OS integrity, and etiology influenced VA. Etiology was associated most commonly with BCVA. In individuals under 40, the combination of intraoperative IVTA resulted in a more significant decrease in logMAR Vas and CFT.
Chronic endometritis increases the recurrence of endometrial polyps in premenopausal women after hysteroscopic polypectomy
Authors: Qu Dacheng , Liu Yue , Zhou Honggui , Wang Zhibiao 
Published: February 2023

Abstract
Background
The reported recurrence rate of endometrial polyps (EPs) after hysteroscopic polypectomy varied widely, and the factors influencing the recurrence of EPs are still controversial. Furthermore, the known definite independent risk factors are almost unchangeable, such as the number of EPs and previous polypectomy history. The aim of this study was to evaluate the impact of chronic endometritis (CE) on the recurrence of EPs in premenopausal women who underwent hysteroscopic polypectomy.

Methods
A retrospective study was conducted at a university-affiliated hospital. Premenopausal women who underwent hysteroscopic polypectomy were enrolled, and those with definite confounding factors for polyp recurrence were excluded, including endometriosis and previous polypectomy history. A total of 233 women were enrolled in this study, including 64 (27.5%) cases with CE and 169 (72.5%) cases without CE. CE was diagnosed via immunohistochemical detection of CD138 on the endometrial specimen. Comparison of the recurrence rate of EPs was performed in women with or without CE at each monitoring stage (i.e., at 3, 6, 9 and 12 months) after hysteroscopic polypectomy.

Results
The recurrence rates of EPs at one year in patients with and without CE were 26.6% (95% confidence interval [CI] 15.8–37.4%) and 9.5% (95% CI 5.0–14.0%), respectively, with an overall recurrence rate of 14.2% (95% CI 9.7–18.7%). The hazard ratio (HR) for EPs recurrence in the EPs with CE cohort versus the EPs without CE cohort was 3.08 (95% CI 1.56–6.09) (P = 0.001). Similarly, the recurrence rate of EPs was significantly higher in women with CE than in those without CE at each monitoring stage (i.e., 3, 6 and 9 months). CE and multiple EPs were risk factors for EPs recurrence. The HR for EPs recurrence in the EPs with CE cohort compared with the EPs without CE cohort was 3.06, after adjustment for the number of EPs.

Conclusions
CE was a harmful factor for the recurrence of EPs in premenopausal women after hysteroscopic polypectomy. Thus, routine screening for CE during hysteroscopic polypectomy was needed. Frequent monitoring was needed for multiple EPs as the number of EPs also contributed to polyp recurrence.
Emergency separation of conjoined twins in a tertiary hospital in Indonesia: three case reports
Authors: Ramlan Andi Ade Wijaya , Zahra Raihanita , Rinaldhy Kshetra , Kapuangan Christopher , Rahendra  , Ferdiana Komang Ayu , Yani Ahmad 
Published: February 2023

Abstract
Background
Emergency separation of conjoined twins is performed when one twin is already dead or dying and threatens the survival of the other. The particular decision to perform an emergency separation of conjoined twins provides an ethical dilemma that needs special attention. Adding to the complexity of surgical and postsurgical management in emergency separation, ethical and sociocultural aspects further complicate decision-making.

Case presentation
From 1987 to 2022, 18 conjoined twin separations were performed in our centre. This paper describes three conjoined twin emergency separations. In the first case of thoracoomphalopagus babies at nine days of age, one baby was diagnosed with necrotizing enterocolitis with frequent desaturation and seizures, and the other baby was healthy. Emergency separation was performed on the twelfth day of age; unfortunately, neither baby survived the surgery. In the second case, emergency separation was performed on the 110th day of life due to sepsis in one baby. The nonseptic twin passed away six hours after surgery, while the septic twin died 12 days after surgery due to wound dehiscence and abdominal sepsis. The third case was of an omphalopagus conjoined twin with a parasitic twin. The healthy baby was deemed nonviable but found to be healthy upon birth. Immediate emergency separation was performed at 2 h of age. The living baby survived the surgery but passed away two months later.

Conclusions
When separation is deemed necessary to save one twin, it becomes difficult to apply standard ethical medical reasoning. The decision to separate results in most cases in very high-risk surgeries with poor outcomes during surgery and postsurgery. Compounded by the complexity of the case, sociocultural and religious aspects further add to the dynamics of decision-making. A multidisciplinary team must work together with a health ethics committee and navigate through this ethical conundrum with the patient and family at its decision-making centre to decide on the best plan of care.
Insights into organoid-based modeling of COVID-19 pathology
Authors: Boroojerdi Mohadese Hashem , Al Jabry Tariq , Mirarefin Seyed Mohamad Javad , Albalushi Halima 
Published: February 2023

AbstractSince December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies.