bluuebunny/crossref_metadata_2025_split huggingface dataset:
СКАРБ КЕЛЬТСЬКИХ МОНЕТ З КОЛИШНЬОГО ВИНОГРАДІВСЬКОГО РАЙОНУ ЗАКАРПАТСЬКОЇ ОБЛАСТІ
Authors: Orlyk Mykhailo 
Published: July 2023

У статті проаналізовано тезаврований у кружальній кераміці скарб, який включав більше 4000 монет типу Медиешул Ауріт. Даний скарб знайдено поблизу городища Мала Копаня, розташованому на теренах колишнього Виноградівського району Закарпатської області. У процесі поширення кельтської культури на Схід у ІІІ ст. до Р. Х. чимало племен, що не належали до кельтської групи, зазнали асимілятивного впливу останніх. Племена костобоківської культури, що належали до фракійської групи, зазнали значного впливу кельтської культури й були, фактично, латинізованими. Саме до костобоківської культури вчені відносять населення городища Мала Копаня. Теоретико-методологічні основи дослідження полягають у поєднанні загальнонаукових, історичних та нумізматичних методів дослідження. Наукова новизна. Загалом історичній та археологічній науці відомо близько 10 скарбів монет типу Медиешул Ауріт, що були знайдені у Східній Європі. Найбільшим скарбом монет такого типу вважався скарб із 107 монет, знайдений у 1903 р. на території Румунії. У статті вперше здійснено спробу проаналізувати в загальних рисах скарб, що включав понад 4 тисячі монет типу Медиешул Ауріт. Автором частково встановлений контекст знахідки та визначено хронологічні межі тезаврації скарбу. Даний скарб розкриває раніше невідомі аспекти грошового обігу на території латинізованих дакійських племен у І ст. до Р. Х. – І ст. н. е. Основні результати дослідження. Особливо цікавим цей скарб робить не лише надзвичайно велика кількість монет у ньому, а й хронологічні межі його тезаврації, що були встановлені нами за допомогою типологічного аналізу кераміки, яка використана для зберігання монет, та проведеного рентгенофлуоресцентного аналізу окремих монет зі скарбу. У статті акцентовано увагу на значних нерівномірностях у складі лігатури монетних знахідок, що підтвердило тривалий час їх перебування в обігу у грошовій системі даного регіону. Автор з урахуванням однотипності монет та їхньої значної кількості у скарбі підтримує гіпотезу Є. Кольникової та В. Котигорошка про те, що в даному регіоні діяв центр карбування монет типу Медиешул Ауріт. Глечик, в якому було тезавровано скарб, віднесено автором до кружального посуду, що також указує на те, що тезаврація скарбу відбулася не пізніше І ст. та могла бути пов‘язаною з бойовими діями або міжплемінними війнами в даному регіоні. За сумою факторів можемо стверджувати, що найбільш імовірний період тезаврації скарбу – початок І ст. У статті акцентовано увагу на тому, що даний скарб вибивається зі статистики знахідок таких монет в цілому як на території України, так і Румунії, що може бути додатковим аргументом на підтвердження гіпотези про існування центру карбування в районі городища Мала Копаня. Висловлено припущення про те, що до даного скарбу увійшла казна городища, яка була, скоріш за все, тезаврована через напад на городище інших дакійських племен на початку І ст.
Humanisation of higher education
Authors: Wallin Patric 
Published: July 2023

Abstract
Transaction, competition and opposition have become imperative in higher education. In this article, I will explore where to go from here building on critical pedagogy and ideas from students-as-partners and undergraduate research. Using the course ‘Environments for learning in higher education’ as an empirical starting point and approaching students’ work through qualitative document analysis, I will explore: (1) what students focus on when given the opportunity to design their own research questions around learning environments; and (2) how they re-imagine and frame future learning environments in the higher education. With this as a backdrop, I will discuss how a critical dialogic teaching praxis can help to think about the university as a place for collaboration between students and academics with the common purpose to co-create knowledge and meaning.
The relationship between kinesiophobia severity and clinical parameters in patients with mechanical low back pain
Authors: Ege Ferhat 
Published: July 2023

BACKGROUND: Low back pain is an important widespread health problem that can occur at any age, causing serious socioeconomic losses. OBJECTIVE: The objective of this study is to investigate the relationship between kinesiophobia severity and pain severity, depression, and quality of life in patients with mechanical low back pain. METHODS: The study sample consisted of 155 patients, of whom 72 were female and 83 were male, aged between 18 and 75 years with mechanical low back pain. Quality of life was assessed with the 36-Item Short Form Health Survey (SF-36), pain intensity with the Visual Analogue Scale (VAS), kinesiophobia with the Tampa Kinesiophobia Scale (TKS), and depression with the Beck Depression Inventory (BDI). Patients were divided into the low (TKS ⩽ 37) and high kinesiophobia (TKS > 37) groups according to the scores they obtained from TKS. RESULTS: VAS-pain severity and BDI scores were significantly higher in the high kinesiophobia group than in the low kinesiophobia group (p< 0.001). On the other hand, the SF-36 subscale scores were significantly higher in the low kinesiophobia group than in the high kinesiophobia group (p< 0.001). The TKS scores were moderately correlated with VAS-pain severity (r= 0.470; p< 0.001) and BDI scores (r= 0.584; p< 0.001) in the positive direction, and strongly correlated with all sub-parameters of quality of life in the negative direction (p< 0.001). CONCLUSION: The results indicated that the severity of kinesiophobia in patients with non-inflammatory low back pain is associated with pain severity, depression, and poor quality of life.
Identification of the enhancer RNAs related to tumorgenesis of pituitary neuroendocrine tumors
Authors: Wang Liangbo , Wei Chenlu , Wang Yu , Huang Ning , Zhang Tao , Dai Yuting , Xue Li , Lin Shaojian , Wu Zhe Bao 
Published: July 2023

BackgroundPituitary neuroendocrine tumors (PitNETs), which originate from the pituitary gland, account for 10%–15% of all intracranial neoplasms. Recent studies have indicated that enhancer RNAs (eRNAs) exert regulatory effects on tumor growth. However, the mechanisms underlying the eRNA-mediated tumorigenesis of PitNETs have not been elucidated.MethodsNormal pituitary and PitNETs tissues were used to identify the differentially expressed eRNAs (DEEs). Immune gene sets and hallmarks of cancer gene sets were quantified based on single sample gene set enrichment analysis (ssGSEA) algorithm using GSVA. The perspective of immune cells among all samples was calculated by the CIBERSORT algorithm. Moreover, the regulatory network composed of key DEEs, target genes of eRNAs, hallmarks of cancer gene sets, differentially expressed TF, immune cells and immune gene sets were constructed by Pearson correlation analysis. Small molecular anti-PitNETs drugs were explored by CMap analysis and the accuracy of the study was verified by in vitro and in vivo experiments, ATAC-seq and ChIP-seq.ResultsIn this study, data of 134 PitNETs and 107 non-tumorous pituitary samples were retrieved from a public database to identify differentially expressed genes. In total, 1128 differentially expressed eRNAs (DEEs) (494 upregulated eRNAs and 634 downregulated eRNAs) were identified. Next, the correlation of DEEs with cancer-related and immune-related gene signatures was examined to establish a co-expression regulatory network comprising 18 DEEs, 50 potential target genes of DEEs, 5 cancer hallmark gene sets, 2 differentially expressed transcription factors, 4 immune cell types, and 4 immune gene sets. Based on this network, the following four therapeutics for PitNETs were identified using Connectivity Map analysis: ciclopirox, bepridil, clomipramine, and alexidine. The growth-inhibitory effects of these therapeutics were validated using in vitro experiments. Ciclopirox exerted potential growth-inhibitory effects on PitNETs. Among the DEEs, GNLY, HOXB7, MRPL33, PRDM16, TCF7, and ZNF26 were determined to be potential diagnostic and therapeutic biomarkers for PitNETs.ConclusionThis study illustrated the significant influence of eRNAs on the occurrence and development of PitNETs. By constructing the co-expression regulation network, GNLY, HOXB6, MRPL33, PRDM16, TCF7, and ZNF26 were identified as relatively significant DEEs which were considered as the novel biomarkers of diagnosis and treatment of PitNETs. This study demonstrated the roles of eRNAs in the occurrence and development of PitNETs and revealed that ciclopirox was a potential therapeutic for pituitary adenomas.
Multi-omic approach to decipher the impact of skincare products with pre/postbiotics on skin microbiome and metabolome
Authors: Li Min , Mao Junhong , Diaz Isabel , Kopylova Evguenia , Melnik Alexey V. , Aksenov Alexander A. , Tipton Craig D. , Soliman Nadia , Morgan Andrea M. , Boyd Thomas 
Published: July 2023

IntroductionAlthough pre/pro/postbiotics have become more prevalent in dermatologic and cosmetic fields, the mode of action when topically applied is largely unknown. A multi-omic approach was applied to decipher the impact of the skincare products with pre/postbiotics on skin microbiome and metabolome.MethodsSubjects with dry skin applied a body wash and body lotion with or without pre/postbiotics for 6 weeks. Skin hydration was measured at baseline, 3 and 6 weeks. Skin swabs were collected for 16S rRNA gene sequencing, metagenomics and metabolomics analysis.ResultsSkin hydration significantly increased in both groups. The prebiotic group significantly reduced opportunistic pathogens, e.g., Pseudomonas stutzeri and Sphingomonas anadarae, and increased the commensals, e.g., Staphylococcus equorum, Streptococcus mitis, Halomonas desiderata. Bacterial sugar degradation pathways were enriched in the prebiotic group, while fatty acid biosynthesis pathways were reduced in control. The changes on skin metabolome profiles by the products were more prominent. The prebiotic group performed greater modulation on many clinically-relevant metabolites compared to control. Correlation analysis showed H. desiderata and S. mitis positively correlated with skin hydration, P. stutzeri and S. anadarae negatively correlated with the metabolites that are positively associated with skin hydration improvement.ConclusionThis holistic study supported a hypothesis that the pre/postbiotics increased skin hydration through the modulation of skin microbiome, metabolic pathways and metabolome.
Glycemic variability correlates with medial temporal lobe atrophy and decreased cognitive performance in patients with memory deficits
Authors: Zhang Shuangmei , Wang Anrong , Liu Shen , Liu Hongyu , Zhu Weifeng , Zhang Zhaoxu 
Published: July 2023

BackgroundIn the past, researchers have observed a significant link between glycemia and dementia. Medial temporal atrophy (MTA) is regarded as a common marker of dementia. The correlation between glycemic variability and MTA is unclear, and it has not been determined whether glycemic variability can be utilized as a biomarker of MTA and cognitive performance.MethodsThe patients in a memory clinic who underwent brain MRI scans and cognitive assessments within the first week of their hospital visit, were enrolled. All participants underwent three fasting blood glucose and one HBA1c assessments on three self-selected days within 1 week of their first visit. The variability independent of the mean (VIM) was employed. Validated visual scales were used to rate the MTA results. The mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) scales were employed to assess the cognitive functions of the participants. Spearman’s correlation and regression models were used to examine the relationship between the MMSE and MoCA scales, and also determine the link between the MRI characteristics and cognitive status, where vascular risk factors, educational status, age, gender, and mean glucose parameters served as covariates.ResultsFour hundred sixty-one subjects completed the MMSE scale, while 447 participants completed the MoCA scale. Data analysis revealed that 47.72% of the participants were men (220/461), and the median age of the patients was 69.87 ± 5.37 years. The findings of Spearman’s correlation analysis exhibited a strong negative relationship between the VIM and MMSE score (r = −0.729, P &lt; 0.01), and the MoCA score (r = −0.710, P &lt; 0.01). The VIM was regarded as an independent risk factor for determining cognitive impairment in both the MMSE and MoCA assessments. The results were unaffected by sensitivity analysis. In addition, a non-linear relationship was observed between the VIM and MTA scores.ConclusionThe variability in the blood glucose levels, which was presented as VIM, was related to the reduced cognitive function, which was reflected by MMSE and MoCA scales. The relationship between the VIM and the MTA score was non-linear. The VIM was positively related to the MTA score when the VIM was less than 2.42.
Polysomnographic study in pediatric neurofibromatosis type 1
Authors: Carotenuto Marco , Messina Giovanni , Esposito Maria , Santoro Claudia , Iacono Diego , Spruyt Karen 
Published: July 2023

BackgroundNeurofibromatosis type 1 (NF1) is a genetic disease that alters neurodevelopment. We aimed to analyze the sleep macrostructure of a sample of children affected by NF1 without neurocognitive co-morbidities and MRI reports of unidentified bright objects (UBOs).MethodsA 100 pre-pubertal children participated in the cross-sectional study: 50 subjects were children diagnosed with NF1 and 50 subjects were typically developing healthy children (TDC). All participants underwent polysomnographic evaluation through which conventional sleep parameters were collected: Total sleep time (TST), Sleep latency (SOL), first REM latency (FRL), number of stage shifts/h (SS/h), number of awakenings/h (AWN/h), wake after sleep onset (WASO%), sleep efficiency percentage (SE%), percentage of sleep time spent in sleep stages 1 (N1%) and 2 (N2%), slow-wave sleep (N3%), and REM sleep (REM%). Additionally, nocturnal respiratory events such as apnea/hypopnea index (AHI), oxygen desaturation index (ODI), and periodic limb movement index (PLMI) were recorded.ResultsNeurofibromatosis type 1 children showed a reduction in sleep duration parameters (TST; p &lt; 0.001), sleep efficiency (SE%; p &lt; 0.001), and stage N2% (p &lt; 0.001). Moreover, the number of awakenings per hour (AWN/h), wake after sleep onset (WASO%), and respiratory events such as AHI, ODI, and PLMI resulted higher in NF1 vs. TDC children.ConclusionThe data showed that the sleep macrostructure differs between NF1 and TDC children. These findings suggest that the evaluation of sleep may provide useful support in corroborating the diagnosis and offers additional therapeutic management perspectives in NF1 and genetic neurodevelopmental disorders in general.
A deep learning approach to estimating initial conditions of Brain Network Models in reference to measured fMRI data
Authors: Kashyap Amrit , Plis Sergey , Ritter Petra , Keilholz Shella 
Published: July 2023

IntroductionBrain Network Models (BNMs) are mathematical models that simulate the activity of the entire brain. These models use neural mass models to represent local activity in different brain regions that interact with each other via a global structural network. Researchers have been interested in using these models to explain measured brain activity, particularly resting state functional magnetic resonance imaging (rs-fMRI). BNMs have shown to produce similar properties as measured data computed over longer periods of time such as average functional connectivity (FC), but it is unclear how well simulated trajectories compare to empirical trajectories on a timepoint-by-timepoint basis. During task fMRI, the relevant processes pertaining to task occur over the time frame of the hemodynamic response function, and thus it is important to understand how BNMs capture these dynamics over these short periods.MethodsTo test the nature of BNMs’ short-term trajectories, we used a deep learning technique called Neural ODE to simulate short trajectories from estimated initial conditions based on observed fMRI measurements. To compare to previous methods, we solved for the parameterization of a specific BNM, the Firing Rate Model, using these short-term trajectories as a metric.ResultsOur results show an agreement between parameterization of using previous long-term metrics with the novel short term metrics exists if also considering other factors such as the sensitivity in accuracy with relative to changes in structural connectivity, and the presence of noise.DiscussionTherefore, we conclude that there is evidence that by using Neural ODE, BNMs can be simulated in a meaningful way when comparing against measured data trajectories, although future studies are necessary to establish how BNM activity relate to behavioral variables or to faster neural processes during this time period.
Evaluating an emerging technology-based biorefinery for edible house crickets
Authors: Psarianos Marios , Ojha Shikha , Schlüter Oliver K. 
Published: July 2023

IntroductionEdible insects, specifically house crickets, are expected to play an important role in the future food systems due to their rich nutritional profile, low environmental impact and growing consumer acceptance as food. Their content of proteins, lipids, chitin and phenolics offer great potential for the valorization of their biomass into nutritional end products and fractions. Furthermore, emerging food processing technologies and green solvents are relevant for improving the valorization process.Materials and methodsHigh pressure (HP) and ultrasound (US) processing were implemented in an insect biorefinery system, where a hexane/methanol/water solvent was used to separate fat, phenolics and a solid fraction containing proteins and chitin. Subsequently, a deep eutectic solvent of betaine and urea (B/U) was used to for protein and chitin isolation.ResultsA maximum of 15% of fat was isolated, with no positive effect from the US or HP treatments. The US treatment enhanced the phenolic extraction yield by 38.69%, while HP negatively affected the antioxidant capacity. B/U was efficient in separating proteins and chitin, resulting in a protein concentrate with a protein content ≥80% and a chitinous fraction with a chitin content ≥70%.ConclusionHouse cricket biomass can be refined into valuable fractions with a quick and simple method, making the process industrially relevant.
Analysis of the nutritional status in the Palestinian territory: a review study
Authors: A. Assaf Enas , Al Sabbah Haleama , Al-Jawadleh Ayoub 
Published: July 2023

BackgroundFood insecurity, occupation, and poverty contribute to the poor nutritional status of Palestine. This review study aimed to analyze the nutritional status in the Palestinian Territory by analyzing published data from 2011 to 2023.MethodSearching for relevant publications yielded 67 studies. Based on reviewing these studies, five major themes were identified: low birth weight, breastfeeding, obesity and overweight, protein-energy malnutrition, and micronutrient deficiency.ResultsBased on the review of these studies, five major themes were identified, namely, low birth weight, breastfeeding, obesity and overweight, protein-energy malnutrition, and micronutrient deficiency. Based on the literature, the prevalence rate of exclusive breastfeeding was 24.4% in the Gaza Strip, compared to a national rate of 39.9% in 2020. Smoking, anemia in mothers, diet during pregnancy, and indoor pollution were associated with low birth weight. One-fifth of the boys and girls were stunted by 2 years of age in the Gaza Strip, and girls were more stunted than boys. The prevalence rates of underweight, overweight, and obesity among school children in the West Bank were 7.3%, 14.5%, and 15.7%, respectively. Age, gender, and living area were significant predictors of being overweight among school children. The prevalence rates of overweight and obesity among adults in Palestine were 57.8% and 26.8%, respectively. Obesity is associated with a family history, chronic diseases, and low physical activity among adults. Exclusive breastfeeding was below the WHO recommendations, while significant rates of obesity and overweight were found among children and adults. Iron-deficiency anemia (IDA) among pregnant women and children remains a challenging public health issue, while other micronutrient deficiencies are high among children.ConclusionThis review emphasizes the need for multi-sectoral interventions to address malnutrition and nutritional shifts. It identifies gaps and addresses nutrition-related issues in the Palestinian Territory, which can serve as a basis for guiding United Nations agencies and governments in formulating evidence-based policies and strategies for prioritizing nutritional interventions to meet sustainable development goals.
TNF-α-1031T/C gene polymorphism as a predictor of malnutrition in patients with gastric cancer
Authors: Fu Liang , Lei Changzhen , Chen Yingxun , Zhu Ruiyun , Zhuang Minling , Dong Liping , Ye Xianghong , Zheng Lushan , Gong Daojun 
Published: July 2023

IntroductionMalnutrition is a complex clinical syndrome, the exact mechanism of which is yet not fully understood. Studies have found that malnutrition is associated with anorexia and inadequate intake, tumor depletion, leptin, tumor-induced metabolic abnormalities in the body, and catabolic factors produced by the tumor in the circulation and cytokines produced by the host immune system. Among these, single nucleotide polymorphisms (SNPs) are present in the gene encoding the pro-inflammatory cytokine TNF-α.AimThe objective of this study was to investigate TNF-α -1,031 T/C gene polymorphism as an unfavorable predictor of malnutrition in patients with gastric cancer.MethodsThe study group consisted of 220 gastric cancer patients treated at Affiliated Jinhua Hospital, Zhejiang University School of Medicine. Malnutrition was mainly assessed by the Global Consensus on Malnutrition Diagnostic Criteria (GLIM). DNA was extracted from peripheral leukocytes of whole blood samples using an animal DNA extraction kit. DNA was amplified using a 1.1× T3 Super PCR mixture and genotyped using SNP1 software.ResultsThere are three major genetic polymorphisms in TNF-α. Among the 220 patients with gastric cancer, there were 7 patients with the CC genotype, 61 with the CT genotype and 152 with the TT genotype. Compared to patients with the TT genotype, patients with the C allele had an approximately 2.5-fold higher risk of developing malnutrition (p = 0.003; OR = 0.406). On the basis of multivariate analysis, patients with the CC genotype had an approximately 20.1-fold higher risk of developing malnutrition (p = 0.013; OR = 20.114), while those with the CT genotype had an almost 3.7-fold higher risk of malnutrition (p = 0.002; OR = 3.218).ConclusionSNP (−1,031 T/C) of the TNF-α may be a useful marker in the assessment of the risk of nutritional deficiencies in gastric cancer patients. Patients with gastric cancer carrying the C allele should be supported by early nutritional intervention, but more research is still needed to explore confirmation.