bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells
Authors: Li Lin , Hu Xiaoyan , Nkwocha Jewel , Sharma Kanika , Kmieciak Maciej , Mann Hashim , Zhou Liang , Grant Steven 
Published: May 2023

Abstract
Purpose
The goal of this study was to characterize the relationship between ATR and STAT3 interactions in human multiple myeloma (MM) cells.

Methods
Various MM cell lines, including IL-6-dependent cells were exposed to ATR inhibitors and effects on STAT3 Tyr705 and Ser727 were monitored by WB analysis and ImageStream analysis. Parallel studies examined induction of cell death, STAT3 DNA binding activity, and expression of STAT3 downstream targets (BCL-XL, MCL-1, c-MYC). Validation was obtained in ATR shRNA knock-down cells, and in cells ectopically expressing BCL-XL, MCL-1, or c-MYC. Analogous studies were performed in primary MM cells and in a MM xenograft model.

Results
Multiple pharmacologic ATR inhibitors inhibited STAT3 Tyr705 (but not Ser727) phosphorylation at low uM concentrations and down-regulated BCL-XL, MCL-1, c-MYC in association with cell death induction. Compatible results were observed in ATR shRNA knock-down cells. Cell death induced by ATR inhibitors was significantly attenuated in cells ectopically expressing constitutively active STAT3, BCL-XL, MCL-1, or c-MYC. Concordant results were observed in primary human MM cells and in an in vivo MM xenograft model.

Conclusions
Collectively, these findings argue for a non-canonical role for the ATR kinase in STAT3 activation in MM cells, and suggest that STAT3 inactivation contributes to the lethal actions of ATR inhibitors in MM.
Understanding and analysing the complex causality of conflicts over marine environments through process tracing
Authors: Boonstra Wiebren Johannes , Dahlet Lol , Eriksson Björn , Selim S. A. , van Putten E. I. 
Published: May 2023

AbstractAs economic activity in marine environments accelerates and expands, conflicts may increase following increased demand over marine resources, unequal distribution of benefits, as well as fluctuating resource availability and quality due to climate change. Anticipation and resolution of these conflicts require understanding of the causal mechanisms through which they originate and persist. Process tracing is a promising social science method that allows producing this knowledge by sequentially ordering events that produce conflict. The aim of this paper is to introduce process tracing as a method for the study of conflicts over marine environments and to assess how the method so far is used in previous studies of conflicts over marine environments. Our review of these studies reveals that scholars of conflicts over marine environments tend to apply process tracing using a deductive approach and a probabilistic understanding of causal mechanisms. The causal mechanisms that are identified to understand the dynamics that drive conflicts over marine environments often include power dynamics between states, institutions, movements or communities. Less articulated is how local social dynamics drives conflicts and how scholars select their cases to represent a wider population of conflicts. We conclude that applying a micro-sociological approach, more attention to case selection, and the interaction between contexts and mechanisms are promising ways forward for further use of process tracing in maritime studies.
Impact of COVID-related Discrimination on Psychological Distress and Sleep Disturbances across Race-Ethnicity
Authors: Strassle Paula D. , Wilkerson Miciah J. , Stewart Anita L. , Forde Allana T. , Jackson Chandra L. , Singh Rupsha , Nápoles Anna María 
Published: May 2023

AbstractCOVID-related discrimination towards historically marginalized racial-ethnic groups in the United States has been well-documented; however, its impact on psychological distress and sleep (overall and within specific racial-ethnic groups) is largely unknown. We used data from our nationally representative, online survey of 5,500 American Indian/Alaska Native, Asian, Black/African American, Native Hawaiian/Pacific Islander, Latino, White, and multiracial adults, conducted from 12/2020-2/2021. Participants were asked how often they experienced discriminatory behaviors “because they think you might have COVID-19” (modified Everyday Discrimination Scale). Psychological distress was captured as having experienced anxiety-depression symptoms (Patient Health Questionairre-4, PHQ-4), perceived stress (modified Perceived Stress Scale), or loneliness-isolation (“How often have you felt lonely and isolated?”). Sleep disturbances were measured using the Patient-Reported Outcomes Information System Short Form Sleep Disturbance scale (PROMIS-SF 4a). Overall, 22.1% reported COVID-related discriminatory behaviors (sometimes/always: 9.7%; rarely: 12.4%). 48.4% of participants reported anxiety-depression symptoms (moderate/severe: 23.7% mild: 24.8%), 62.4% reported feeling stressed (moderate/severe: 34.3%; mild: 28,1%), 61.0% reported feeling lonely-isolated (fairly often/very often: 21.3%; almost never/sometimes: 39.7%), and 35.4% reported sleep disturbances (moderate/severe:19.8%; mild: 15.6%). Discrimination was only associated with increased psychological distress among racial-ethnic minorities. For example, COVID-related discrimination was strongly associated with anxiety-depression among Black/African American adults (mild: aOR=2.12, 95% CI=1.43-5.17; moderate/severe: aOR=5.19, 95% CI=3.35-8.05), but no association was observed among White or multiracial adults. Mitigating pandemic-related discrimination could help alleviate mental and sleep health disparities occurring among minoritized racial-ethnic groups.
Physical Regime Sensitivity
Authors: Prime M. B. , Merson J. S. , Chen S.-R. 
Published: May 2023

AbstractThis work presents a novel sensitivity approach that quantifies sensitivity to regimes of a model’s state variables rather than constitutive model parameters. This Physical Regime Sensitivity (PRS) determines which regimes of a model’s independent variables have the biggest influence on an experiment or application. PRS analysis is demonstrated on a strength model used in the simulation of a copper Taylor cylinder. In a series of simulations, the strength model was perturbed sequentially in local regimes of plastic strain, plastic strain rate, temperature and pressure, and then the prediction of cylinder shape was compared to unperturbed calculations. Results show, for example, that the deformed length of the cylinder was most sensitive to strength at a strain rate of 1.0 × 104/sec., but the deformed footprint radius was most sensitive to strength at a strain rate of about 4.0 × 104/sec. Compared to current histogram approaches, PRS can be used to design or interpret integrated experiments by identifying not just which regimes are accessed somewhere in the experiment but the causality question of which regimes actually affect the measured data. PRS should allow one to focus experimental and modeling efforts where they are most needed and to better interpret experiments.
Pulses of Cold Atlantic Water in the Arctic Ocean From an Ocean Model Simulation
Authors: Fu Chuanshuai , Pennelly Clark , Garcia‐Quintana Yarisbel , Myers Paul G. 
Published: May 2023

AbstractThe intrusion of the warm and saline Atlantic Water (AW) has significant implications and feedback on the dynamics and thermodynamics of the Arctic Ocean. The AW enters the Arctic Ocean through two gateways: Fram Strait (FS) and the Barents Sea Opening (BSO). The AW is the dominant source of oceanic heat to the Arctic Ocean. In conjunction with the measurements in key hydrographic sections, numerical ocean modeling provides us with a useful tool to characterize and corroborate the temporal and spatial variability of the AW branches. Simulations are conducted using the regional configuration Arctic and North Hemispheric Atlantic (ANHA) of the ocean/sea‐ice model Nucleus for Modeling of the Ocean running at 1/4° and 1/12° resolution. Online passive tracers from the model configuration are used to trace the pathways of the AW inflow in the Arctic Ocean. While studying the variability of the AW through FS and the BSO, a cold mode of AW (Cold Atlantic Water [CAW]) with a temperature below 0℃ is detected along the rim of the eastern Eurasian Basin. It is formed primarily due to the intense sea surface cooling of the AW in the Barents and Kara Seas. The CAW exhibits the cascading process as it propagates downstream through the St. Anna Trough, leading to a considerable mixing with the ambient water. The CAW pulses eventually result in a significant heat content reduction in the eastern Arctic. This study provides insight into the changing AW property and its potential impact on the Arctic Basin.
Tectonic Evolution of a Sedimented Oceanic Transform Fault: The Owen Transform Fault, Indian Ocean
Authors: Janin Alexandre , Chamot‐Rooke Nicolas , Delescluse Matthias , Fournier Marc , Olive Jean‐Arthur , Rabaute Alain , Huchon Philippe , Dyment Jérôme , Vigny Christophe , Rodriguez Mathieu 
Published: May 2023

AbstractThe Owen transform fault (OTF) connecting the Sheba and the Carlsberg spreading ridges in the Indian Ocean currently forms the active plate boundary between India and Somalia plates. This 330‐km‐long transform fault is by far the longest transform fault along the India‐Somalia plate boundary and its valley is buried under the thick distal turbidites of the Indus Fan with total thickness ranging from 1,000 to >5,000 m. A new set of seismic reflection and multibeam bathymetric data reveals remarkable transpressive structures along its entire length recorded as folds in the sedimentary cover, eruption of mud ridges at the seafloor, thrusts in the young oceanic lithosphere. Based on a new regional time‐calibration of the seismic reflectors, we show that sediments in the transform valley (post 8.6 Ma) recorded a period of tectonic quiescence until the onset of a transpressive event around 1.5–2.4 Ma that we relate to a minor change in India‐Somalia kinematics not captured by magnetic anomalies. This tectonic regime is still active based on compressive earthquakes and deformation of the most recent sediments. Transpression resulted in the formation of a proto‐median ridge and the coeval propagation of the tip of the Carlsberg Ridge into the Somalian plate. These features are typically encountered at many other transform faults but rarely captured in their very early stage.
A novel microRNA-182/Interleukin-8 regulatory axis controls osteolytic bone metastasis of lung cancer
Authors: Zhao Ming-Na , Zhang Ling-Fei , Sun Zhen , Qiao Li-Hua , Yang Tao , Ren Yi-Zhe , Zhang Xian-Zhou , Wu Lei , Qian Wen-Li , Guo Qiao-Mei , Xu Wan-Xing , Wang Xue-Qing , Wu Fei , Wang Lin , Gu Yutong , Liu Mo-Fang , Lou Jia-Tao 
Published: May 2023

AbstractBone metastasis is one of the main complications of lung cancer and most important factors that lead to poor life quality and low survival rate in lung cancer patients. However, the regulatory mechanisms underlying lung cancer bone metastasis are still poor understood. Here, we report that microRNA-182 (miR-182) plays a critical role in regulating osteoclastic metastasis of lung cancer cells. We found that miR-182 was significantly upregulated in both bone-metastatic human non–small cell lung cancer (NSCLC) cell line and tumor specimens. We further demonstrated that miR-182 markedly enhanced the ability of NSCLC cells for osteolytic bone metastasis in nude mice. Mechanistically, miR-182 promotes NSCLC cells to secrete Interleukin-8 (IL-8) and in turn facilitates osteoclastogenesis via activating STAT3 signaling in osteoclast progenitor cells. Importantly, systemically delivered IL-8 neutralizing antibody inhibits NSCLC bone metastasis in nude mice. Collectively, our findings identify the miR-182/IL-8/STAT3 axis as a key regulatory pathway in controlling lung cancer cell-induced osteolytic bone metastasis and suggest a promising therapeutic strategy that targets this regulatory axis to interrupt lung cancer bone metastasis.
A molecular descriptor of intramolecular noncovalent interaction for regulating optoelectronic properties of organic semiconductors
Authors: Liu Meihui , Han Xiao , Chen Hao , Peng Qian , Huang Hui 
Published: May 2023

AbstractIn recent years, intramolecular noncovalent interaction has become an important means to modulate the optoelectronic performances of organic/polymeric semiconductors. However, it lacks a deep understanding and a direct quantitative relationship among the molecular geometric structure, strength of noncovalent interaction, and optoelectronic properties in organic/polymeric semiconductors. Herein, upon systematical theoretical calculations on 56 molecules with and without noncovalent interactions (X···Y, X = O, S, Se, Te; Y = C, F, O, S, Cl), we reveal the essence of the interactions and the dependence of its strength on the molecular geometry. Importantly, a descriptor S is established as a function of several basic geometric parameters to well characterize the noncovalent interaction energy, which exhibits a good inverse correlation with the reorganization energies of the photo-excited states or electron-pumped charged states in organic/polymeric semiconductors. In particular, the experimental 1H, 77Se, and 125Te NMR, the optical absorption and emission spectra, and single crystal structures of eight compounds fully confirm the theoretical predictions. This work provides a simple descriptor to characterize the strength of noncovalent intramolecular interactions, which is significant for molecular design and property prediction.
Investigating the oral microbiome in retrospective and prospective cases of prostate, colon, and breast cancer
Authors: Nearing Jacob T. , DeClercq Vanessa , Langille Morgan G. I. 
Published: May 2023

AbstractThe human microbiome has been proposed as a potentially useful biomarker for several cancers. To examine this, we made use of salivary samples from the Atlantic Partnership for Tomorrow’s Health (PATH) project and Alberta’s Tomorrow Project (ATP). Sample selection was divided into both a retrospective and prospective case control design examining prostate, breast, and colon cancer. In total 89 retrospective and 260 prospective cancer cases were matched to non-cancer controls and saliva samples were sequenced using 16S rRNA gene sequencing. We found no significant differences in alpha diversity. All beta diversity measures were insignificant except for unweighted UniFrac profiles in retrospective breast cancer cases and weighted UniFrac, Bray-Curtis and Robust Atchinson’s distances in colon cancer after testing with age and sex adjusted MiRKAT models. Differential abundance (DA) analysis showed several taxa that were associated with previous cancer in all three groupings. Only one genus (ClostridiaUCG-014) in breast cancer and one ASV (Fusobacterium periodonticum) in colon cancer was identified by more than one DA tool. In prospective cases three ASVs were associated with colon cancer, one ASV with breast cancer, and one ASV with prostate cancer. Random Forest classification showed low levels of signal in both study designs in breast and prostate cancer. Contrastingly, colon cancer did show signal in our retrospective analysis (AUC: 0.737) and in one of two prospective cohorts (AUC: 0.717). Our results indicate that it is unlikely that reliable microbial oral biomarkers for breast and prostate cancer exist.. However, further research into the oral microbiome and colon cancer could be fruitful.
Catalytic enantioselective nucleophilic desymmetrization of phosphonate esters
Authors: Formica Michele , Rogova Tatiana , Shi Heyao , Sahara Naoto , Ferko Branislav , Farley Alistair J. M. , Christensen Kirsten E. , Duarte Fernanda , Yamazaki Ken , Dixon Darren J. 
Published: May 2023

AbstractMolecules that contain a stereogenic phosphorus atom are crucial to medicine, agrochemistry and catalysis. While methods are available for the selective construction of various chiral organophosphorus compounds, catalytic enantioselective approaches for their synthesis are far less common. Given the vastness of possible substituent combinations around a phosphorus atom, protocols for their preparation should also be divergent, providing facile access not only to one but to many classes of phosphorus compounds. Here we introduce a catalytic and enantioselective strategy for the preparation of an enantioenriched phosphorus(V) centre that can be diversified enantiospecifically to a wide range of biologically relevant phosphorus(V) compounds. The process, which involves an enantioselective nucleophilic substitution catalysed by a superbasic bifunctional iminophosphorane catalyst, can accommodate a wide range of carbon substituents at phosphorus. The resulting stable, yet versatile, synthetic intermediates can be combined with a multitude of medicinally relevant O-, N- and S-based nucleophiles.
β-adrenergic receptor agonist promotes ductular expansion during 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced chronic liver injury
Authors: Tanimizu Naoki , Ichinohe Norihisa , Mitaka Toshihiro 
Published: May 2023

AbstractIntrahepatic nerves are involved in the regulation of metabolic reactions and hepatocyte-based regeneration after surgical resection, although their contribution to chronic liver injury remains unknown. Given that intrahepatic nerves are abundant in the periportal tissue, they may be correlated also with cholangiocyte-based regeneration. Here we demonstrate that isoproterenol (ISO), a β-adrenergic receptor agonist, promoted ductular expansion induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in vivo. Immunofluorescence analysis shows that nerve fibers positive for tyrosine hydroxylase form synaptophysin-positive nerve endings on epithelial cell adhesion molecule-positive (EpCAM+) cholangiocytes as well as on Thy1+ periportal mesenchymal cells (PMCs) that surround bile ducts, suggesting that the intrahepatic biliary tissue are targeted by sympathetic nerves. In vitro analyses indicate that ISO directly increases cAMP levels in cholangiocytes and PMCs. Mechanistically, ISO expands the lumen of cholangiocyte organoids, resulting in promotion of cholangiocyte proliferation, whereas it increases expression of fibroblast growth factor 7, a growth factor for cholangiocytes, in PMCs. Taken together, the results indicate that intrahepatic sympathetic nerves regulate remodeling of bile ducts during DDC-injury by the activation of β-adrenergic receptors on cholangiocytes and PMCs.
Multi-criteria decision-making for prioritizing photocatalytic processes followed by TiO2-MIL-53(Fe) characterization and application for diazinon removal
Authors: Barjasteh-Askari Fateme , Nabizadeh Ramin , Najafpoor Aliasghar , Davoudi Mojtaba , Mahvi Amir-Hossein 
Published: May 2023

AbstractMulti-criteria decision-making (MCDM) can introduce the best option based on evidence. We integrated the Analytic Hierarchy Process (AHP) and the Technique for Order of Preference by Similarity to the Ideal Solution (TOPSIS) to prioritize the alternatives for photocatalytic diazinon removal in a bench scale and characterized TiO2-MIL-53(Fe) for this purpose. Criteria and alternatives were listed based on systematic literature reviews and expert opinions. Then, AHP and TOPSIS questionnaires were developed and distributed to an expert panel for pairwise comparisons. We converted the linguistic variables into the corresponding fuzzy values and used R for mathematical calculations. Then, TiO2-MIL-53(Fe) was synthesized and characterized for diazinon removal under LED visible light. The AHP ranked criteria as availability > degradation efficiency > safety for the environment > material cost > energy consumption > mineralization efficiency > photocatalyst reusability > safety for personnel > equipment cost. Based on TOPSIS, the order of alternatives was TiO2-containing/Visible light > ZnO-containing/UV light > TiO2-containing/UV light > ZnO-containing/Visible light > WO3-containing/UV light. With a bandgap of 1.8 eV, TiO2-MIL-53(Fe) could remove 89.35% of diazinon at 10 mg/L diazinon concentration, 750 mg/L catalyst dose, pH 6.8, and 180-min reaction time. Hybrid AHP-TOPSIS identified the best option for photocatalytic diazinon removal from aqueous solutions. Thus, MCDM techniques can use systematic review results to overcome the uncertainty in designing experimental studies.
Monitoring resistance to methomyl and synergism in the non-target Musca domestica from cotton fields of Punjab and Sindh provinces, Pakistan
Authors: Khan Hafiz Azhar Ali 
Published: May 2023

AbstractInsecticides are an integral part of most of the cropping systems worldwide; however, these usually exert negative impact on the environment and non-target insects as well. Non-target insects are prone to develop resistance to insecticides due to prolonged and repeated lethal and sublethal exposures. Musca domestica is a common non-target, pollinator and nectar feeder species in cotton ecosystem, besides its status as a public health pest in human habitations. In the present work, resistance to methomyl, one of the major insecticides used for cotton pest management, was assessed in 20 M. domestica strains from the major cotton producing areas of the Punjab and Sindh provinces of Pakistan. The results revealed that toxicity values of methomyl for Punjabi and Sindhi strains ranged from 28.07 to 136.16 µg fly−1 and 29.32 to 136.87 µg fly−1, respectively. Among Punjabi strains, D.G. Khan, Lodhran, Bahawalpur, Toba Tek Singh, Bahawalnagar, Rajanpur and Jhang strains exhibited very high levels of resistance (RR > 100) to methomyl; Bhakkar, Kasur, Vehari, Layyah, Muzaffargarh and R.Y. Khan showed high resistance (RR = 51–100 fold), while the Mianwali strain showed a moderate level of resistance to methomyl (RR = 36.45 fold). In case of Sindhi strains, very high levels of resistance (> 100 fold) were reported for Sukkar and Sanghar strains, high levels of resistance (RR 51–100 fold) for Khairpur, Jamshoro and Ghotki, and moderate resistance to methomyl (38.08 fold) in the Dadu strain. There was a significant synergism of methomyl toxicity in all field strains when methomyl bioassayed along with piperonyl butoxide (PBO) and S,S,S-tributylphosphorotrithioate (DEF) providing clues of metabolic-based mechanisms of resistance to methomyl. In conclusion, insecticides used in crop farming can cause resistance development in non-target M. domestica. It is necessary to adopt the pest management activities that are safe for the environment and non-target insect species.