bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENENTUAN JENIS PELARUT TERBAIK TERHADAP KADAR EURYCUMANONE PADA EKSTRAKSI AKAR PASAK BUMI (EURYCOMA LONGIFOLIA JACK)
Authors: Malik Kirana , Setyaningrum Dyah , Wulansari Laela , Andayani Andayani , Shihran Laviany Putri , Fauziyyah Isra 
Published: July 2023

Pasak bumi (Eurycoma longifolia Jack) adalah salah satu tanaman herbal dari negara-negara Asia Tenggara yaitu Indonesia, Malaysia, dan Vietnam. Bagian tanaman yang memiliki khasiat adalah bagian daun, akar dan batang. Berbagai macam senyawa kimia telah diisolasi dan dikarakterisasi dari Eurycoma longifolia, serta diketahui memiliki berbagai efek yang menguntungkan seperti male fertility enhancement effect, antimalarial effect, cytotoxic and anti-proliferative effect, antimicrobial effects, anti-inflammatory effects, anti-anxiolytic, anti diabetic, osteoporosis preventive effect, ameliorative effect, ergoganic effect, insecticidal effects, muscular effect, antiulcer effect dan anti-rheumatism effect. Tanaman ini sangat potensial untuk digunakan dalam produk farmasi herbal. Komposisi senyawa kimia dari tumbuhan adalah esensial untuk penentuan kualitas, keamanan dan efektifitas dari produk herbal. Penelitian ini dilakukan untuk mengetahui kandungan eurycomanone pada ekstrak akar pasak bumi, serta mengetahui pelarut terbaik dalam proses ekstraksi dari akar pasak bumi yang menghasilkan kadar eurycomanone tertinggi. Metode pembuatan ekstrak dengan cara melakukan maserasi simplisia akar pasak bumi menggunakan pelarut etanol 30%, etanol 70%, etanol 96%, n-heksana, etilsetat dan air. Tahap awal penelitian dimulai dengan melakukan uji fitokimia dan uji kadar air pada simplisa. Selanjutnya pada masing-masing ekstrak dilakukan uji toksisitas terhadap larva udang serta penentuan kadar eurycomanone dengan High-performance liquid chromatography (HPLC). Hasil rendemen ekstrak pasak bumi tertinggi terdapat pada ekstrak dengan menggunakan pelarut etanol 70% sebesar 3.41 g. Hasil pengujian fitokimia simplisia pasak bumi mengandung flavonoid dan saponin. Toksisitas tertinggi terdapat pada ekstrak dengan menggunakan pelarut etilasetat dengan nilai LC50 sebesar 201.28 ppm. Ekstrak pasak bumi dengan pelarut etanol 70% memiliki kadar eurycomanone tertinggi yaitu 53.42 mg/g.
NEUROTIC DISTRESS TOKOH NARUSE JUN DALAM ANIME KOKORO GA SAKEBITAGATTERUNDA KARYA MARI OKADA DENGAN PENDEKATAN PSIKOANALISIS SOSIAL KAREN HORNEY
Authors: Azhari Deasy Bintang , Listyaningsih  
Published: July 2023

Penelitian ini membahas neurotic distress pada tokoh Naruse Jun dalam anime Kokoro Ga Sakebitagatterunda dan merumuskan faktor penyebab dan cara mengatasi neurotic distres dengan pendekatan teori psikoanalisis sosial milik Karen Horney. Teknik pengumpulan data menggunakan teknik dokumentasi dan dengan teknik analisis deskriptif. Kesimpulan dari penelitian ini adalah penyebab awal dari neurotic distres yaitu kecemasan dasar dan permusuhan dasar oleh orang tuanya sendiri. Selain itu terdapat konflik yaitu konflik intrapsikis yang terdapat diri rendah yang berasal dari evaluasi bersifat negatif dari orang tuanya dan diri ideal yang Naruse ciptakan berbentuk khayalan dan keyakinan yang membuatnya menjadi tertutup dan tidak berbicara. Dalam konflik interpersonal terdapat kebutuhan kasih sayang dan penerimaan, kebutuhan partner, membatasi hidup pada ruang lingkup yang sempit, pengakuan sosisal dan mencukupi diri. Cara mengatasi neurotic distress yang dialami Naruse yaitu dengan cara memperbaiki dua konflik tersebut. Pada konflik Interpersonal Naruse mempunyai kecenderungan mendekat, cara ini hampir berhasil dalam membantu mengungkapkan apa yang ingin diutarakan, namun tidak saat mendengar Sakagami tidak memiliki rasa yang sama. Pada konflik Intrapsikis dengan melalui penyadaran diri yang dilakukan Sakagami dengan mengubah benci diri menjadi menerima diri, memberhentikan fantasi yang akhirnya Naruse dapat berdamai dengan masa lalunya.
Kata kunci: Anime; neurotic; psikoalisis sosial
Recalcitrant Grover’s Disease Successfully Managed with Dupilumab and Naltrexone in a Middle-Aged Woman: A Case Study
Authors: Beiter Kaylin , Behnam Christy , Shields Bridget 
Published: July 2023

Introduction: Grover’s disease, or transient acantholytic dermatosis, is a common benign papulovesicular disorder that often affects elderly men. It is typically managed with topical therapeutics in this population. We present here an uncommon case of Grover’s disease, occurring in a relatively younger patient, that was recalcitrant to typical therapeutics modalities.
Case Report: A 45-year-old woman presented to our clinic with a several month history of discrete, pink, ill-defined pruritic papules on her torso with sparing of her extremities. Grover’s disease was diagnosed based on her clinical presentation and subsequently biopsy-confirmed. She failed multiple topical medications, oral acitretin, and only experience minimal relief when transitioned to Naltrexone. Dupilumab was added to her regimen, with rapid improvement. She was eventually transitioned down to dupilumab monotherapy, and has remained clear since.
Conclusion: Grover’s disease is not common among middle-aged women. Novel therapies, such as biologics, have been efficacious in elderly (especially male) populations with this condition. Our case demonstrates the importance of attempting new treatment modalities such as dupilumab for patients with recalcitrant disease. Novel application of these biologic treatments may be needed in particular for atypical cases, such as when patients do not fit the known epidemiologic profile.
Deucravacitinib, an Oral, Selective, Allosteric Tyrosine Kinase 2 Inhibitor, in Moderate to Severe Plaque Psoriasis: Efficacy by Baseline Demographic and Disease Characteristics in the Phase 3 POETYK PSO-1 and PSO-2 Trials
Authors: Gooderham Melinda , Spelman Lynda , Imafuku Shinichi , Romanelli Marco , Merola Joseph F. , Armstrong April W. , Colston Elizabeth , Banerjee Subhashis , Scharnitz Thomas , Blauvelt Andrew 
Published: July 2023

Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved in the US and other countries for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. In the POETYK PSO-1 (NCT03624127) and PSO-2 (NCT03611751) trials, deucravacitinib was superior to placebo and apremilast in patients with moderate to severe plaque psoriasis. This analysis evaluated deucravacitinib efficacy by baseline characteristics.
Methods: Efficacy endpoints, including ≥75% reduction from baseline in Psoriasis Area and Severity Index (PASI 75) and static Physician’s Global Assessment score of 0 (clear) or 1 (almost clear) (sPGA 0/1), were evaluated at Week 24 by baseline subgroups including weight, sex, and PASI in the pooled PSO-1 and PSO-2 population, and at Week 52 in PSO-1 patients who received continuous deucravacitinib treatment from Day 1.
Results: In the pooled PSO-1 and PSO-2 population, deucravacitinib (n=843) was more efficacious than apremilast (n=422) at Week 24 across subgroups defined by baseline weight (<90 kg: PASI 75, 69.8% vs 43.8%, sPGA 0/1, 60.2% vs 34.2%; ≥90 kg: PASI 75, 55.4% vs 31.5%, sPGA 0/1, 45.9% vs 25.6%), sex (male: PASI 75, 59.3% vs 33.7%, sPGA 0/1, 49.6% vs 24.7%; female: PASI 75, 70.4% vs 45.2%, sPGA 0/1, 60.9% vs 39.4%), and PASI (≤20: PASI 75, 61.6% vs 38.6%, sPGA 0/1, 53.5% vs 32.4%; >20: PASI 75, 64.7% vs 37.0%, sPGA 0/1: 53.2% vs 27.1%). Consistent efficacy was observed through Week 52 in patients who received continuous deucravacitinib treatment in PSO-1 (n=332), regardless of baseline characteristics.
Conclusion: Deucravacitinib demonstrated consistent efficacy for up to 52 weeks regardless of baseline characteristics in patients with moderate to severe plaque psoriasis.

Acknowledgments

This study was sponsored by Bristol Myers Squibb
Writing and editorial assistance was provided by Liz Rockstein, PhD, of Peloton Advantage, LLC, an OPEN Health company, funded by Bristol Myers Squibb
Safety of Tazarotene 0.045% Lotion and Hyperpigmentation Improvements in Black Participants With Moderate-to-Severe Acne
Authors: Cook-Bolden Fran , Stein Gold Linda , Baldwin Hilary , Callender Valerie , Alexis Andrew , Bhatia Neal , Zeichner Joshua , Tanghetti Emil , Guenin Eric 
Published: July 2023

Introduction: Post-inflammatory hyperpigmentation (PIH) that results from acne in patients with skin of color may be more distressing than the acne itself, and likely impacts patients with higher skin phototypes more greatly than those with lower skin phototypes. Topical retinoids, a mainstay of acne treatment, can also reduce hyperpigmentation. For example, significant PIH improvements with a cream formulation of the retinoid tazarotene (0.1%) were observed following 16 weeks of treatment in patients with acne. However, skin irritation and other skin reactions may limit use of some tazarotene gel and cream formulations. A hydrating, lower-dose tazarotene 0.045% lotion formulation utilizes polymeric emulsion technology to allow for more efficient delivery of tazarotene into dermal layers while reducing potential for skin irritation. This pooled, post hoc analysis evaluates safety of tazarotene 0.045% lotion and its effect on hyperpigmentation in Black individuals with acne.
Methods: In two identical phase 3 randomized, double-blind, vehicle-controlled, studies (NCT03168321; NCT03168334), participants aged ≥9 years with moderate-to-severe acne (Evaluator's Global Severity Score of 3/4) were randomized (1:1) to once-daily tazarotene 0.045% or vehicle lotion for 12 weeks. Safety evaluations included adverse events (AEs) reports and investigator-assessed hyperpigmentation (4-point scale: 0 [none] to 3 [severe]). Post hoc analyses were based on participants’ self-identification of race, including ‘Black or African American’ (herein referred to as Black).
Results: Of 1,614 participants randomized in the two phase 3 studies, 262 (16%) self-identified as Black. The safety population comprised 253 Black participants. The most common TEAEs with tazarotene 0.045% lotion were at the application site: pain (6.6%), exfoliation (5.0%), and dryness (3.3%). No Black participants reported application site irritation or dermatitis with tazarotene lotion. Hyperpigmentation rates in Black participants, which were high at baseline, decreased by week 12 with tazarotene treatment (40.5% to 31.4%) compared to vehicle (37.9% to 37.2%).
Conclusions: Acne regimens that maximize efficacy while mitigating irritation is key to managing acne in patients with skin of color, given the higher pigmentary alteration risk in melanin-rich skin. Tazarotene 0.045% lotion was safe and well tolerated in Black participants, with no application-site irritation or dermatitis after 12 weeks of once-daily treatment. Tazarotene also led to improvements in hyperpigmentation, an inflammation-associated sequala of acne. As PIH can take longer than 12 weeks to resolve with treatment, additional improvements in hyperpigmentation may be expected with continued tazarotene 0.045% lotion use.
Support: Ortho Dermatologics.
Impact of Age or Sex on Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%/Benzoyl Peroxide 3.1%/Adapalene 0.15% Gel in Participants with Moderate-to-Severe Acne
Authors: Stein Gold Linda , Kircik Leon , Werschler William , Baldwin Hilary , Callender Valerie , Green Lawrence , Sadick Neil , Sugarman Jeffrey , Draelos Zoe , Tanghetti Emil , Bhatia Neal 
Published: July 2023

Introduction: IDP-126 (clindamycin phosphate 1.2%/benzoyl peroxide [BPO] 3.1%/adapalene 0.15%) polymeric mesh gel is the first triple-combination, fixed-dose topical acne treatment in development. IDP-126 demonstrated superior efficacy to vehicle and component dyads, with good safety/tolerability, in a phase 2 and two phase 3 studies of participants with moderate-to-severe acne. The objective of this analysis was to assess the impact of age or sex on efficacy and safety/tolerability of IDP-126 gel.
Methods: This post hoc analysis evaluated effect of age or sex on efficacy/safety of IDP-126 using data pooled from two phase 3, double-blind, randomized, 12-week studies (NCT04214639, N=183; NCT04214652, N=180). Participants aged ≥9 years with moderate-to-severe acne were randomized 2:1 to once-daily IDP-126 gel or vehicle gel. Data were analyzed by age (pediatric [9-17 years]: n=178; adult [≥18 years]: n=185) or sex (females: n=212; males: n=151). Endpoints included ≥2-grade reduction from baseline in Evaluator’s Global Severity Score and clear/almost clear skin (treatment success) and least-squares mean percent change from baseline in inflammatory and noninflammatory lesion counts. Treatment-emergent adverse events (TEAEs) were also assessed.
Results: At week 12, over half of pediatric and almost half of adult IDP-126-treated participants achieved treatment success (52.7% and 45.9%, respectively) versus one-fourth with vehicle (24.0% and 23.5%; P<0.01, both). Results by sex were similar (IDP‑126 vs vehicle: females: 53.7% vs 23.0%; males: 43.1% vs 24.6%; P<0.05, both). IDP‑126 provided >70% reductions in inflammatory and noninflammatory lesions in all subgroups, versus 41%-63% with vehicle (P≤0.001, all). Differences between sex or age groups were not statistically significant. Most TEAEs were of mild-moderate severity in all groups.
Conclusions: Fixed-dose, triple-combination IDP-126 gel was efficacious and well tolerated in participants with moderate-to-severe acne, regardless of age or sex, with approximately half of participants achieving clear/almost clear skin.
Funding: Ortho Dermatologics
Formation of modern professional stereotypes of teachers as a condition for the formation of a resilient rural school
Authors: Ефремова-Шершукова Н. А. , Пивоварова А.В. , Сартакова Е.Е. 
Published: July 2023

В статье обосновывается понятие резильентности, доказывается тезис о том, что степень резильентности школы обуславливается профессиональной деятельностью учителя, сформированными в педагогическом коллективе общепринятыми алгоритмами реализации конкретных трудовых функций, в том числе в области управления качеством образования на педагогическом уровне, взаимодействия с другими участниками образовательных отношений и участниками отношений в сфере образования. Приводится анализ результатов исследования уровня сформированности профессиональной компетентности учителей сельских школ, целью которого было выявить группы профессиональных стереотипов педагогической деятельности учителей сельских школ Томской области. Обосновывается связь научных понятий «резильентность» и «Профессиональные педагогические стереотипы», описываются основания для систематики стереотипов педагогов сельских школ.
The article substantiates the concept of resilience, proves the thesis that the degree of school resilience is determined by the professional activities of the teacher, the generally accepted algorithms for the implementation of specific labor functions, formed in the teaching staff, including in the field of education quality management at the pedagogical level, interaction with other participants in educational relations and participants in relations in the field of education. An analysis of the results of a study of the level of formation of professional competence of teachers in rural schools is given, the purpose of which was to identify groups of professional stereotypes of pedagogical activity of teachers in rural schools in the Tomsk region. The connection between the scientific concepts of "resilience" and "Professional pedagogical stereotypes" is substantiated, the grounds for the systematics of stereotypes of rural school teachers are described.
The model of formation of competence of social interaction in the conditions of distance learning in the Chinese audience of students
Authors: Иньчжоу П. 
Published: July 2023

Педагогика в Китае имеет легендарное прошлое, насчитывающее тысячелетия. Конфуцианство долгое время было центральным элементом китайской педагогики с акцентом на чрезмерное образование и личностный рост. Кроме того, акцент был сделан на культивировании культурной утонченности и эстетической чувствительности. В настоящее время в китайской педагогике происходят изменения и развитие. Стремление к совершенствованию и реформе китайской образовательной структуры необходимо для того, чтобы идти в ногу с новыми требованиями и вызовами. Акцент на превосходной педагогике также имеет первостепенное значение, поскольку это может привести к повышению качества образования и способствовать развитию личности учащегося. Китай активно занимается научными исследованиями и новаторскими образовательными методами. Подготовка педагогических кадров является важнейшим компонентом китайской педагогики. В стране существует отточенная система профессионального образования, гарантирующая первоклассное обучение и развитие учащихся. Наряду с этим инновационные технологии произвели революцию в китайской педагогике и языковом образовании, особенно в русском. Следовательно, инновации китайской педагогики стали жизненно важными для прогресса в области образования и обучения в стране.
Pedagogy in China has a legendary past dating back thousands of years. Confucianism has long been a central element of Chinese pedagogy with an emphasis on excessive education and personal growth. In addition, emphasis was placed on cultivating cultural sophistication and aesthetic sensitivity. Currently, changes and development are taking place in Chinese pedagogy. Striving for improvement and reform of the Chinese educational structure is necessary in order to keep up with new requirements and challenges. The emphasis on excellent pedagogy is also of paramount importance, as it can lead to an improvement in the quality of education and contribute to the development of the student's personality. China is actively engaged in scientific research and innovative educational methods. The training of teaching staff is an essential component of Chinese pedagogy. There is a well-honed system of vocational education in the country, which guarantees first-class education and development of students. Along with this, innovative technologies have revolutionized Chinese pedagogy and language education, especially in Russian. Consequently, the innovations of Chinese pedagogy have become vital for the progress in education and training in the country.
ИЗЛУЧЕНИЕ, ВОЗНИКАЮЩЕЕ ПРИ ЗАХВАТЕ СВОБОДНОГО ЭЛЕКТРОНА В КАНАЛИРОВАННОЕ СОСТОЯНИЕ
Authors: Калашников Н. П. , Ольчак А. С. 
Published: July 2023

При влете заряженной частицы в монокристалл происходит перестройка плоской волновой функции свободного электрона в суперпозицию локализованных волновых функций дискретных состояний движения в режиме каналирования. Перестройка волновой функции электрона из свободного в каналированное состояние может произойти упруго, но может и сопровождаться квазихарактеристическим переходным электромагнитным излучением, возникающим на границе кристалла. Это переходное излучение дополняет хорошо известный тип излучения, возникающий в глубине кристалла при переходах каналированных частиц между дискретными состояниями квазисвязанного поперечного движения. Цель статьи – сравнение интенсивностей этих двух типов излучения.
International cooperation in the conditions of the NCTS joint transit system : in Ukrainian dimension
Authors: Fostolovych Valentyna , Mykhalchyshyna Larysa , Simanaviciene Zaneta 
Published: July 2023

The purpose of the study was to determine the main aspects of simplifying conditions and creating prospects for international cooperation in terms of Ukraine's participation in the NCTS joint transit system. Examining the data of the State Customs Service of Ukraine and the State Statistics Service of Ukraine, the intensive work of the subjects of the regime of the joint transit system during the period of NCTS in Ukraine was noted. Confirm the need to simplify the conditions for the international movement of goods, analysis of the growth dynamics of Ukraine's foreign trade. According to the results of the research, it was revealed that by applying the provisions of the Convention, the prevention of fraud with accompanying documents is implemented, the security of international transportation is increased and uniform forms of customs control are recognized by all 36 participating countries.
After analyzing the benefits for the subjects of the customs regime, a decrease in the cost of customs procedures was noted; saving time on the duration of customs procedures; unloading checkpoints in queues; acceleration of the flow of trade in the international trade system.
The whole model of work in the NCTS system is an innovative approach and needed a lot of work and transformation of the work of both the State Customs Service of Ukraine itself and the regulation of regulatory support. The condition of mandatory financial guarantee and sealing of all movements became the basis for the development of a new mechanism for the implementation of these procedures that meet the requirements of the Convention.
The practical application of the processed results is carried out in stages. To date, the implementation of appropriate IT solutions based on MASP-C is already being implemented. Gradually, the technology of administration of customs payments is being improved and the Customs Code of Ukraine is being brought into line with the Customs Code of the EU.
Alih Kode dan Campur Kode dalam Saluran Youtube Tasya Farasya
Authors: Khofifah Nur , Ripai Ahmad , Utami H. R. 
Published: July 2023

The purpose of this study is to describe the form and factors that influence the occurrence of code switching and code mixing. The method used in this study is a qualitative descriptive method. The data collection technique in this study is the free-of-talk (SBLC) listening technique. Presentation of data in descriptive form using ordinary words. The results of this study are the first, the type of code switching that occurs in Tasya Farasya's YouTube channel. Second, the types of code mixing that occur on Tasya Farasya's YouTube channel are divided into two, namely internal code mixing and external code mixing. Third, the factors that cause code switching include; ) speakers; (2) interlocutor; (3) limited language equivalents; (4) maintain prestige; and (5) the custom of a particular field. The factors that cause code mixing include (1) changing the topic of conversation (2) limited language equivalents; (3) speakers; (4) speech partners; and (5) maintain prestige. Circumstances based on the place and atmosphere as well as the object of the conversation change in various situations with the interlocutorKeywords: code switching, code mixing, speech eventsAbstrak Tujuan penelitian ini adalah mendeskripsikan wujud dan faktor yang mempengaruhi terjadinya alih kode dan campur kode. Metode yang digunakan dalam penelitian ini ialah metode deskriptif kualitatif. Teknik pengumpulan data pada penelitian ini ialah teknik simak bebas libat cakap (SBLC). Penyajian data dalam bentuk dekriptif dengan menggunakan kata-kata biasa. Hasil penelitian ini ialah pertama ialah, jenis alih kode yang terjadi dalam saluran YouTube Tasya Farasya. Kedua, jenis campur kode yang terjadi dalam saluran YouTube Tasya Farasya terbagi menjadi dua, yaitu campur kode ke dalam dan campur kode ke luar. Ketiga, faktor-faktor penyebab terjadinya alih kode meliputi; 1) penutur; (2) lawan tutur; (3) keterbatasan padanan bahasa; (4) menjaga gengsi; dan (5) kebiasaan bidang tertentu. Adapun faktor-faktor penyebab terjadinya campur kode meliputi (1) perubahan topik pembicaraan (2) keterbatasan padanan bahasa; (3) penutur; (4) mitra tutur; dan (5) menjaga gengsi. Keadaan yang didasarkan pada tempat dan suasana serta objek pembicaraan berubah dalam berbagai situasi dengan lawan tutur. Kata kunci: alih kode, campur kode, peristiwa tutur