bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism and inhibitory effects of cactus (Opuntia dillenii) extract on melanocytes and its potential application for whitening cosmetics
Authors: Chiu Chien-Shan , Cheng Yu-Tsung , Chan Yung-Jia , Lu Wen-Chien , Yang Kai-min , Li Po- Hsien 
Published: January 2023

AbstractPenghu cactus (Opuntia dillenii [Ker.] Haw) is a cactus plant that commonly grows in Penghu Island, Taiwan, Republic of China (ROC). However, still lack of scientific study on the Opuntia dillenii [Ker.] Haw extract on skin-whitening-associated tyrosinase activity and melanin production. The activities of its extract in melanogenesis were investigated in this article. In this experiment, we used an extract from the Penghu cactus (Opuntia dillenii [Ker.] Haw) to study its tyrosinase inhibition, anti-melanin generation, UV-protection effects and wound healing capacity in B16-F10 melanocytes. Without reducing cell growth greatly or causing cell death, 20 g/L cactus extract effectively inhibited the melanin production of B16-F10 cells, and melanogenesis was induced by 3-isobutyl-1-methylxanthine. The cactus extract could also promote cell proliferation. Cactus extract treatment decreased the mRNA expression of insulin-like growth factor 1 (IGF-1) and vascular endothelial growth factor (VEGF) and increased that of transforming growth factor β (TGF-β). Thus, it could reduce cell melanin production and promote cell growth but by also reducing IGF-1 and VEGF mRNA expression, may reduce wound scarring and prevent tumor proliferation and swelling. Increasing TGF-β mRNA expression can help increase collagen to remove wrinkles and help in wound healing. Skin patch test results agreed with in vitro results with B16-F10 melanoma cells. The cactus extract significantly inhibited tyrosinase activity and reduced melanin production, showing a whitening effect on skin tests. Cactus may be a good natural candidate for inhibiting melanin production and promoting cell proliferation.
Titanium-protein nanocomposites as new biomaterials produced by high-pressure torsion
Authors: Floriano Ricardo , Edalati Kaveh , Pereira Karina Danielle , Luchessi Augusto Ducati 
Published: January 2023

AbstractThe development of new biomaterials with outstanding mechanical properties and high biocompatibility has been a significant challenge in the last decades. Nanocrystalline metals have provided new opportunities in producing high-strength biomaterials, but the biocompatibility of these nanometals needs to be improved. In this study, we introduce metal-protein nanocomposites as high-strength biomaterials with superior biocompatibility. Small proportions of bovine serum albumin (2 and 5 vol%), an abundant protein in the mammalian body, are added to titanium, and two nanocomposites are synthesized using a severe plastic deformation process of high-pressure torsion. These new biomaterials show not only a high hardness similar to nanocrystalline pure titanium but also exhibit better biocompatibility (including cellular metabolic activity, cell cycle parameters and DNA fragmentation profile) compared to nano-titanium. These results introduce a pathway to design new biocompatible composites by employing compounds from the human body.
Environmental filling materials based on phosphogypsum powder with municipal solid waste incineration ash
Authors: Yin Longlong , Guo Qing , Wang Xiao , Yuan Jing , Zhang Qianfeng 
Published: January 2023

AbstractA new building filling materials (NBFM) using phosphogypsum and municipal solid waste incineration (MSWI) fly ash is prepared in this paper. The effects of MSWI fly ash dosage and MSWI fly ash water washing pretreatment on mechanical properties, setting time, metal leaching, hydration products and microstructure of NBFM are analyzed by a range of experimental studies. The results indicate that the mechanical properties, setting time and the density of micro interface of NBFM are optimal when the MSWI fly ash dosage is 3%. The mechanical properties of NBFM rise and the condensation time and leaching concentration of heavy metals decline after washing the MSWI fly ash. With the increase of the curing age, the metal element leaching of NBFM decreases, and when the curing age is 7 days, the solidification effect of NBFM on most metal elements meets the standard of Chinese code (GB5085.3-2007). The feasibility of MSWI fly ash and phosphogypsum as filling materials for building engineering is verified, and the change of macroscopic properties of NBFM is explained as well.
Intraday adaptation to extreme temperatures in outdoor activity
Authors: Fan Yichun , Wang Jianghao , Obradovich Nick , Zheng Siqi 
Published: January 2023

AbstractLinkages between climate and human activity are often calibrated at daily or monthly resolutions, which lacks the granularity to observe intraday adaptation behaviors. Ignoring this adaptation margin could mischaracterize the health consequences of future climate change. Here, we construct an hourly outdoor leisure activity database using billions of cell phone location requests in 10,499 parks in 2017 all over China to investigate the within-day outdoor activity rhythm. We find that hourly temperatures above 30 °C and 35 °C depress outdoor leisure activities by 5% (95% confidence interval, CI 3–7%) and by 13% (95% CI 10–16%) respectively. This activity-depressing effect is larger than previous daily or monthly studies due to intraday activity substitution from noon and afternoon to morning and evening. Intraday adaptation is larger for locations and dates with time flexibility, for individuals more frequently exposed to heat, and for parks situated in urban areas. Such within-day adaptation substantially reduces heat exposure, yet it also delays the active time at night by about half an hour, with potential side effect on sleep quality. Combining empirical estimates with outputs from downscaled climate models, we show that unmitigated climate change will generate sizable activity-depressing and activity-delaying effects in summer when projected on an hourly resolution. Our findings call for more attention in leveraging real-time activity data to understand intraday adaptation behaviors and their associated health consequences in climate change research.
Uncertainty quantification of multi-scale resilience in networked systems with nonlinear dynamics using arbitrary polynomial chaos
Authors: Zou Mengbang , Fragonara Luca Zanotti , Qiu Song , Guo Weisi 
Published: January 2023

AbstractComplex systems derive sophisticated behavioral dynamics by connecting individual component dynamics via a complex network. The resilience of complex systems is a critical ability to regain desirable behavior after perturbations. In the past years, our understanding of large-scale networked resilience is largely confined to proprietary agent-based simulations or topological analysis of graphs. However, we know the dynamics and topology both matter and the impact of model uncertainty of the system remains unsolved, especially on individual nodes. In order to quantify the effect of uncertainty on resilience across the network resolutions (from macro-scale network statistics to individual node dynamics), we employ an arbitrary polynomial chaos (aPC) expansion method to identify the probability of a node in losing its resilience and how the different model parameters contribute to this risk on a single node. We test this using both a generic networked bi-stable system and also established ecological and work force commuter network dynamics to demonstrate applicability. This framework will aid practitioners to both understand macro-scale behavior and make micro-scale interventions.
Sensorimotor recalibration of postural control strategies occurs after whole body vibration
Authors: Rigoni Isotta , Degano Giulio , Hassan Mahmoud , Fratini Antonio 
Published: January 2023

AbstractEfficient postural control results from an effective interplay between sensory feedbacks integration and muscle modulation and can be affected by ageing and neuromuscular injuries. With this study, we investigated the effect of whole-body vibratory stimulation on postural control strategies employed to maintain an upright posture. We explored both physiological and posturography metrics, through corticomuscular and intramuscular coherence, and muscle networks analyses. The stimulation disrupts balance in the short term, but leads to a greater contribution of cortical activity, necessary to modulate muscle activation via the formation of (new) synergies. We also observed a reconfiguration of muscle recruitment patterns that returned to pre-stimulation levels after few minutes, accompanied by a slight improvement of balance in the anterior–posterior direction. Our results suggest that, in the context of postural control, appropriate mechanical stimulation is capable of triggering a recalibration of the sensorimotor set and might offer new perspectives for motor re-education.
Prognostic impact of examined lymph-node count for patients with esophageal cancer: development and validation prediction model
Authors: Yuan Shasha , Wei Chen , Wang Mengyu , Deng Wenying , Zhang Chi , Li Ning , Luo Suxia 
Published: January 2023

AbstractEsophageal cancer (EC) is a malignant tumor with high mortality. We aimed to find the optimal examined lymph node (ELN) count threshold and develop a model to predict survival of patients after radical esophagectomy. Two cohorts were analyzed: the training cohort which included 734 EC patients from the Chinese registry and the external testing cohort which included 3208 EC patients from the Surveillance, Epidemiology, and End Results (SEER) registry. Cox proportional hazards regression analysis was used to determine the prognostic value of ELNs. The cut-off point of the ELNs count was determined using R-statistical software. The prediction model was developed using random survival forest (RSF) algorithm. Higher ELNs count was significantly associated with better survival in both cohorts (training cohort: HR = 0.98, CI = 0.97–0.99, P < 0.01; testing cohort: HR = 0.98, CI = 0.98–0.99, P < 0.01) and the cut-off point was 18 (training cohort: P < 0.01; testing cohort: P < 0.01). We developed the RSF model with high prediction accuracy (AUC: training cohort: 87.5; testing cohort: 79.3) and low Brier Score (training cohort: 0.122; testing cohort: 0.152). The ELNs count beyond 18 is associated with better overall survival. The RSF model has preferable clinical capability in terms of individual prognosis assessment in patients after radical esophagectomy.
A combined model of child malnutrition and morbidity in Ethiopia using structural equation models
Authors: Takele Kasahun , Zewotir Temesgen , Ndanguza Denis 
Published: January 2023

AbstractMalnutrition and morbidity are substantial problems in Ethiopia and are still pervasive and persistent. Despite this, there has been scant research on the coexistence of malnutrition and morbidity indicators. Moreover, previous studies were based on all data records of measurements from manifest data. Thus, this study aims to identify the correlates and coexistence of child malnutrition and morbidity within this country. Cross-sectional data which is collected by Ethiopia Demographic and Health Survey were used. The generalized structural equation models were used to examine the association between child malnutrition, morbidity, and potential risk factors. The generalized structural equation models help to provide latent effects of child malnutrition and morbidity within a combined modeling framework. In addition, the generalized structural equation models make it possible to analyze malnutrition as a mediator of the association between selected risk factors and latent variable morbidity. The data analysis was done using SPSS AMOS and R software. The analysis indicated that children born to nourished mothers (AOR = 0.71, 95% CI 0.68–0.75), born to enough birth space between 24 and 47 months and (AOR = 0.93, 95% CI 0.88–0.99), 48 months and above (AOR = 0.71, 95% CI 0.65–0.76), being from middle-income households (AOR = 0.85, 95% CI 0.78–0.91), high-income households (AOR = 0.66, 95% CI 0.61–0.72), from mother with primary or secondary (AOR = 0.79, 95% CI 0.75–0.85) and higher education level (AOR = 0.57, 95% CI 0.41–0.78) were less affected by malnutrition. It also revealed that a child born second to third (AOR = 0.87, 95% CI 0.77–0.99), fourth and higher (AOR = 0.88, 95% CI 0.79–0.99) and children from a husband-educated higher level (AOR = 0.76, 95% CI 0.64–0.89) were less likely to be ill. Children who breastfeed (AOR = 0.98, 95% CI 0.80–0.99), from nourished mothers (AOR = 0.96, 95% CI 0.94–0.097), from middle income (AOR = 0.97, 95% CI 0.96–0.99), high-income households (AOR = 0.94, 95% CI 0.93–0.96), birth spacing 24–47 months (AOR = 0.99, 95% CI 0.98–1.00) and 48 months and above (AOR = 0.96, 95% CI 0.94–0.97) were indirectly affected by morbidity via malnutrition. This investigation has revealed that childhood malnutrition and morbidity remain major child health challenges in Ethiopia with demographic, socioeconomic, maternal, child, and geographic variables playing significant roles. Efforts to resolve these issues need to take these factors into account. Therefore, malnutrition and morbidity prevention should include encouraging birth spacing, mother education programs, and breastfeeding practices.
Histologic changes in immune-tolerant patients with chronic hepatitis B: a systematic review and meta-analysis
Authors: Li Zhiguo , Yang Dongliang , Ge Yue , Song Shu , Lv Qin , Ye Yong’an 
Published: January 2023

AbstractThe serological diagnostic criteria for the immune-tolerant (IT) phase have not been strictly defined and it is hard to determine an accurate rate for significant histologic changes among IT patients. The aim of this study was to establish a baseline rate of significant histologic changes and to determine the main characteristics of IT patients. We systematically searched PubMed, Embase, and Web of Science. Studies reporting liver biopsy results (inflammation grade or fibrosis stage) for adults with chronic hepatitis B virus (HBV) infection in the IT phase diagnosed by serological criterion were included to pool the rate of significant histologic changes. Studies that enrolled subjects with confirmed chronic HBV infection in the IT phase diagnosed by serological and liver biopsy criteria (dual criteria) were included to pool the mean values of main characteristics among IT patients. Of 319 studies screened, 15 were eventually included in the meta-analysis. The pooled rates of significant liver fibrosis and inflammatory activity for 10 studies were 10% (95% confidence interval [CI] 0.06–0.18) and 16% (95% CI 0.07–0.31), respectively. The pooled mean values of age, alanine aminotransferase level, HBV DNA level, and HBsAg level for another 5 studies with IT patients diagnosed by dual criteria were 30.7 years (95% CI 27.31–34.09), 26.64 IU/mL (95% CI 24.45–28.83), 8.41 log10 cp/mL (95% CI 7.59–9.23), and 4.24 log10 IU/mL (95% CI 3.67–4.82), respectively. Significant histologic changes were not rare events among IT patients. Strictly defined serological diagnostic criteria for the IT phase are warranted.
Extreme local recycling of moisture via wetlands and forests in North-East Indian subcontinent: a Mini-Amazon
Authors: Ganguly Akash , Oza Harsh , Padhya Virendra , Pandey Amit , Chakra Swagatika , Deshpande R. D. 
Published: January 2023

AbstractMoisture recycling in precipitation is an important hydrological process, accounting for ~ 67% globally. North-east India, home to the world's wettest place, boasts vast wetlands and forest-cover. Despite its proximity to the coast, we find locally recycled moisture to be the primary annual source of rainfall (~ 45%). During the pre-monsoon season, the enriched δ18O (~ − 0.7 ‰) and high d-excess (~ 14 ‰) are ascribed to enhanced transpiration, owing to atmospheric instability which causes Nor’westers. During the Monsoon season, oceanic flux provides increased surficial moisture, enabling deep-localised convection via evaporation. Significant localised recycling, even during the Monsoon season is estimated (~ 38%), with predominantly high d-excess in precipitation during latter half of the monsoon with increased moisture contribution from floods in Brahmaputra (high d-excess). The increasing δ18O and d-excess during the post-monsoon season is associated with progressively lesser rainout history and increased localized recycling (~ 67%). In light of the dwindling wetlands and forest-cover, our study highlights their indispensable role in governing regional hydro-meteorology and water availability.
High accuracy gender determination using the egg shape index
Authors: Kayadan Muhammed , Uzun Yunus 
Published: January 2023

AbstractSince only female chicks are used in layer hens, usually hatched male chicks are killed. It is estimated that around 7 billion chicks per year are killed immediately after hatching. In addition to being unethical, this situation also causes great financial losses. Sex determination in chicks can be done before or after hatching. Of course, determinations made before hatching are more advantageous, but the prediction rate is relatively low. The morphology of an egg is expressed in terms of the Shape Index (SI), which is the ratio of the short diameter to the long diameter. In this study, male and female chicks were predicted by using the shape index of the eggs using the RUSBoost Classifier using Shape Index. Although SI varied according to the egg type, a significant correlation (r = 0.78) was observed between chick sex and SI. Therefore, it was possible to estimate gender by utilizing SI in chickens, even if the accuracy of classification was not as high as in ducks. Besides the SI, mass, short axis, long axis, ovality, volume, eccentricity parameters were obtained and used for the results. With this features, females classified with 80% and males classified 81% correctly. The model predictions were applied to the probability of female chick hatching equation from the previous studies, 71% of the estimations were correctly classified according to this equation.With this work, around 80% of accurate predictions were made. In this case, killing 5.65 billion chicks can be prevented. Likewise, many eggs are not wasted. 1.13 billion USD loss can be prevented.
Nanoformulation of the K-Ras(G12D)-inhibitory peptide KS-58 suppresses colorectal and pancreatic cancer-derived tumors
Authors: Sakamoto Kotaro , Qi Yun , Miyako Eijiro 
Published: January 2023

AbstractSingle amino acid mutations of Ras occur in 30% of human cancers. In particular, K-Ras(G12D) has been detected in the majority of intractable colorectal and pancreatic cancers. Although efforts to target K-Ras(G12D) are currently underway, no effective drugs are available. We previously found that the K-Ras(G12D)-inhibitory bicyclic peptide KS-58 exhibits antitumor activity against syngeneic colon and orthotopic grafted pancreatic tumors; however, pristine KS-58 is difficult to handle because of low water solubility and it requires frequent administration to obtain sufficient antitumor activity. In this study, we used a nanoformulation of KS-58 prepared with the highly biocompatible surfactant Cremophor® EL (CrEL) to improve water solubility and reduce the dosing frequency. Nanoformulations of KS-58 with CrEL dramatically improved its water solubility and increased its stability. Weekly intravenous administration of KS-58 nanoparticles (NPs) suppressed the growth of CT26 and PANC-1 cell-derived tumors in vivo, and fluorescent bioimaging indicated that the NP-encapsulated near-infrared fluorescent probe indocyanine green selectively accumulated in the tumor and was safely excreted through the kidneys following intravenous injection. Histopathological analysis of CT26 tumors and Western blotting of PANC-1 tumors revealed that KS-58 NPs reduced ERK phosphorylation, a downstream signal of K-Ras(G12D). Our results suggest that KS-58 NPs represent a novel therapeutic agent for treating colorectal and pancreatic cancers.
Lexical Predictors of Intelligibility in Young Children's Speech
Authors: Mahr Tristan J. , Hustad Katherine C. 
Published: January 2023

Purpose:
Speech perception is a probabilistic process, integrating bottom-up and top-down sources of information, and the frequency and phonological neighborhood of a word can predict how well it is perceived. In addition to asking how intelligible speakers are, it is important to ask how intelligible individual words are. We examined whether lexical features of words influenced intelligibility in young children. In particular, we applied the neighborhood activation model, which posits that a word's frequency and the overall frequency of a word's phonological competitors jointly affect the intelligibility of a word.

Method:
We measured the intelligibility of 165 children between 30 and 47 months in age on 38 different single words. We performed an item response analysis using generalized mixed-effects logistic regression, adding word-level characteristics (target frequency, neighborhood competition, motor complexity, and phonotactic probability) as predictors of intelligibility.

Results:
There was considerable variation among the words and the children, but between-word variability was larger in magnitude than between-child variability. There was a clear positive effect of target word frequency and a negative effect of neighborhood competition. We did not find a clear negative effect of motor complexity, and phonotactic probability did not have any effect on intelligibility.

Conclusion:
Word frequency and neighborhood competition both had an effect on intelligibility in young children's speech, so listener expectations are an important factor in the selection of items for children's intelligibility assessment.
An Overview of Telepractice Applications for Comprehensive Cochlear Implant Service Delivery
Authors: Premkumar Priya K. , Hughes Michelle L. 
Published: January 2023

Purpose:
Numerous follow-up appointments are required to program a cochlear implant (CI) sound processor and monitor the patient's progress over time, particularly within the first year of implantation. This, coupled with the specialty nature of CI service delivery and sparsely located clinics, can pose burdens on recipients' time and access to necessary resources for consistent follow-up. Advances in the application of telepractice for CI service delivery have evolved and expanded over recent years, with further utilization spurred by the COVID-19 pandemic that emerged in late 2019. This review article provides a summary of telepractice applications for adult and pediatric CI processor programming, impedance, and electrically evoked compound action potential testing, speech-perception testing, evaluations of patient and clinician experiences, troubleshooting, and aural rehabilitation for CI recipients. Future directions and opportunities for further implementation of telepractice for CI service delivery are discussed.

Conclusions:
Studies to date suggest that telepractice can be reliably used for remote sound processor programming for both children and adults, impedance and evoked compound action potential measures, speech-perception testing in adult CI users, and self-monitoring. However, further technological advancements are needed to make remote speech-perception testing more easily implemented, and well-controlled studies are needed to better evaluate the efficacies of aural rehabilitation through teletherapy, particularly for children.