bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood pressure and 10-year all-cause mortality: Findings from the PERU MIGRANT Study
Authors: Hidalgo-Benites Aida , Senosain-Leon Valeria , Carrillo-Larco Rodrigo M. , Ruiz-Alejos Andrea , Gilman Robert H. , Smeeth Liam , Miranda J. Jaime , Bernabé-Ortiz Antonio 
Published: January 2023

Background The long-term impact of elevated blood pressure on mortality outcomes has been recently revisited due to proposed changes in cut-offs for hypertension. This study aimed at assessing the association between high blood pressure levels and 10-year mortality using the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) and the American College of Cardiology and the American Heart Association (ACC/AHA) 2017 blood pressure guidelines. Methods Data of the PERU MIGRANT Study, a prospective ongoing cohort, was used. The outcome of interest was 10-year all-cause mortality, and exposures were blood pressure categories according to the JNC-7 and ACC/AHA 2017 guidelines. Log-rank test, Kaplan-Meier and Cox regression models were used to assess the associations of interest controlling for confounders. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated. Results A total of 976 records, mean age of 60.4 (SD: 11.4), 513 (52.6%) women, were analyzed. Hypertension prevalence at baseline almost doubled from 16.0% (95% CI 13.7%–18.4%) to 31.3% (95% CI 28.4%–34.3%), using the JNC-7 and ACC/AHA 2017 definitions, respectively. Sixty-three (6.4%) participants died during the 10-year follow-up, equating to a mortality rate of 3.6 (95% CI 2.4–4.7) per 1000 person-years. Using JNC-7, and compared to those with normal blood pressure, those with pre-hypertension and hypertension had 2-fold and 3.5-fold increased risk of death, respectively. Similar mortality effect sizes were estimated using ACC/AHA 2017 for stage 1 and stage 2 hypertension. Conclusions Blood pressure levels under two different definitions increased the risk of 10-year all-cause mortality. Hypertension prevalence doubled using ACC/AHA 2017 compared to JNC-7. The choice of blood pressure cut-offs to classify hypertension categories need to be balanced against the patients benefit and the capacities of the health system to adequately handle a large proportion of new patients.
On the issue of the need for preventive work of the juvenile affairs inspector in the aspect of media security of minors
Authors: Kharlamova Darya 
Published: January 2023

Currently, the information society is developing at a high speed, in fact, almost everyone uses the Internet on a regular basis. The global rate of Internet usage has increased significantly over the past few decades. Although this trend is observed in all age groups, it is most pronounced among minors. The expansion of interactive online activities seems to be encouraging young people to stay online longer than expected.
It is known that excessive use of the Internet increases the tendency to develop destructive behavior on the Internet. Such high-risk behavior can have a detrimental effect both on the psychological development of adolescents and on the formation of their further behavior. We must not forget that when using the Network, you can get both necessary and useful information and "false" information. In most cases, it is minors who are exposed to negative information due to their age and psychological characteristics.
In addition, groups with a destructive orientation are being formed on the Network, which broadcast aggression, cruelty, hatred, calls for suicidal behavior, which can subsequently lead to the formation of destructive behavior on the part of minors and an increase in the commission of offenses and crimes. Currently, due to the aggravated situation in the world, it is much more common to notice the spread of negative information on the Internet, as well as "false" information that can negatively affect the formation of the worldview of minors, value orientations and further behavior.
Of course, on the one hand, the use of the Network gives a minor the opportunity to satisfy their necessary needs, such as communication, searching for information, watching movies and useful videos, etc. But on the other hand, certain risks appear to a greater extent in the use of uncontrolled communications by minors, access to negative content appears.
We emphasize that the main preventive activities should be carried out by law enforcement agencies. Due to the fact that the protection of the rights of minors is within the competence of the Juvenile Affairs Unit (hereinafter PDN), first of all, preventive activities should be carried out by PDN inspectors.
Pedagogical neglect as a factor determining juvenile delinquency
Authors: Teregulova Oxana , Kosolapov Artem , Ermolov Pavel 
Published: January 2023

The article considers the problem of formation and development of pedagogical neglect. Pedagogical neglect of minors is associated with the peculiarities of their social situation and is due to psychological and pedagogical reasons.
The problem of pedagogical neglect is considered from the point of view of various sciences, including pedagogy. The article lists the reasons for the formation of this phenomenon. The interrelation of pedagogical neglect and the commission of offenses by minors is described. The influence of family and other socio-psychological factors on the attitude of a minor to education and upbringing is also emphasized. The status and situation of juvenile delinquents in the educational team is analyzed.
Pedagogically neglected children, due to improper upbringing, can quickly adjust when the conditions of upbringing or training change. The article presents measures of psychological and pedagogical influence in order to stimulate a minor to activity.
The Number of Estimates in Footnotes and Accruals
Authors: Chen Huafeng (Jason) , Chen Jason Victor , Li Feng 
Published: January 2023

This study quantifies the number of estimates involved in firms’ accruals and examines whether it is informative about the relation between accruals and future earnings. We measure the number of estimates using the frequency of the use of the word estimate in the qualitative portions of a firm’s Notes to the Financial Statements (footnotes). Motivated by arguments regarding the impact of estimation errors in accruals, we hypothesize and find that the accruals of firms that have more estimates have a lower relation with future earnings (i.e., lower persistence) and a lower association with their past, current, and future cash flows. This paper was accepted by Suraj Srinivasan, accounting. Funding: This work was supported by Zijiang Endowment. H. Chen acknowledges the financial support from the National Natural Science Foundation of China [Grants 72150710550, 71790591, and 72121002]. J. V. Chen acknowledges the financial support from the University of Michigan, University of Illinois at Chicago, Paton Accounting Fellowship, and Harry Jones Endowment. F. Li acknowledges the financial support from SJTU SAIF Zijiang Discipline Development Fund, sponsored by the Zijiang Foundation. Supplemental Material: The internet appendix and data are available at https://doi.org/10.1287/mnsc.2022.4659 .
High-Q cascaded single-passband microwave photonic filter based on an optical-electrical feedback loop
Authors: Duan Ruodong , Song Yansong , Wang Tianshu , Zhu Hongfei , Du Lei 
Published: January 2023

A cascaded microwave photonic filter refers to a microwave photonic filter (MPF) with higher performance obtained by cascading a MPF with two different structures. A high-Q cascaded single-passband MPF is proposed experimentally based on stimulated Brillouin scattering (SBS) and an optical-electrical feedback loop (OEFL). In this experiment, the pump light of SBS is provided by a tunable laser. The Brillouin gain spectrum generated by the pump light is used to amplify the phase modulation sideband, and the narrow linewidth OEFL is subsequently used to compress the passband width of the MPF. By carefully adjusting the pump wavelength and tuning the tunable optical delay line, stable tuning can be achieved for a cascaded single-passband MPF with a high-Q value. The results have demonstrated that the MPF has characteristics of high-frequency selectivity and a wide frequency tuning range. Meanwhile, the filtering bandwidth is up to 300 kHz, the out-of-band suppression is more than 20 dB, the maximum Q-value is

5.333

×

1

0

4

, and the center frequency tuning range is 1–17 GHz. The cascaded MPF proposed not only achieves a higher Q-value, but also has the advantages of tunability, a high out-of-band rejection ratio, and strong cascaded ability.
Classical imaging with undetected photons using four-wave mixing in silicon core fibers
Authors: Huang M. , Wu D. , Ren H. , Shen L. , Hawkins T. W. , Ballato J. , Gibson U. J. , Beresna M. , Slavík R. , Sipe J. E. , Liscidini M. , Peacock A. C. 
Published: January 2023

Undetected-photon imaging allows for objects to be imaged in wavelength regions where traditional components are unavailable. Although first demonstrated using quantum sources, recent work has shown that the technique also holds with classical beams. To date, however, all the research in this area has exploited parametric down-conversion processes using bulk nonlinear crystals within free-space systems. Here, we demonstrate undetected-photon-based imaging using light generated via stimulated four-wave mixing within highly nonlinear silicon fiber waveguides. The silicon fibers have been tapered to have a core diameter of

∼
915

nm

to engineer the dispersion and reduce the insertion losses, allowing for tight mode confinement over extended lengths to achieve practical nonlinear conversion efficiencies (

∼
−
30

dB

) with modest pump powers (

∼
48

mW

). Both amplitude and phase images are obtained using classically generated light, confirming the high degree of spatial and phase correlation of our system. The high powers (

>
10

nW

) and long coherence lengths (

>
4

km

) associated with our large fiber-based system result in high contrast and stable images.
Predicting the combined effects of case isolation, safe funeral practices, and contact tracing during Ebola virus disease outbreaks
Authors: Bouba Aliou , Helle Kristina Barbara , Schneider Kristan Alexander 
Published: January 2023

Background
The recent outbreaks of Ebola virus disease (EVD) in Uganda and the Marburg virus disease (MVD) in Ghana reflect a persisting threat of Filoviridae to the global health community. Characteristic of Filoviridae are not just their high case fatality rates, but also that corpses are highly contagious and prone to cause infections in the absence of appropriate precautions. Vaccines against the most virulent Ebolavirus species, the Zaire ebolavirus (ZEBOV) are approved. However, there exists no approved vaccine or treatment against the Sudan ebolavirus (SUDV) which causes the current outbreak of EVD. Hence, the control of the outbreak relies on case isolation, safe funeral practices, and contact tracing. So far, the effectiveness of these control measures was studied only separately by epidemiological models, while the impact of their interaction is unclear.

Methods and findings
To sustain decision making in public health-emergency management, we introduce a predictive model to study the interaction of case isolation, safe funeral practices, and contact tracing. The model is a complex extension of an SEIR-type model, and serves as an epidemic preparedness tool. The model considers different phases of the EVD infections, the possibility of infections being treated in isolation (if appropriately diagnosed), in hospital (if not properly diagnosed), or at home (if the infected do not present to hospital for whatever reason). It is assumed that the corpses of those who died in isolation are buried with proper safety measures, while those who die outside isolation might be buried unsafely, such that transmission can occur during the funeral. Furthermore, the contacts of individuals in isolation will be traced. Based on parameter estimates from the scientific literature, the model suggests that proper diagnosis and hence isolation of cases has the highest impact in reducing the size of the outbreak. However, the combination of case isolation and safe funeral practices alone are insufficient to fully contain the epidemic under plausible parameters. This changes if these measures are combined with contact tracing. In addition, shortening the time to successfully trace back contacts contribute substantially to contain the outbreak.

Conclusions
In the absence of an approved vaccine and treatment, EVD management by proper and fast diagnostics in combination with epidemic awareness are fundamental. Awareness will particularly facilitate contact tracing and safe funeral practices. Moreover, proper and fast diagnostics are a major determinant of case isolation. The model introduced here is not just applicable to EVD, but also to other viral hemorrhagic fevers such as the MVD or the Lassa fever.
Gender differences in dry eye disease symptoms associated with psychological health indicators among adults using mobile mental health apps
Authors: Kim Hyojin , An Youngju , Hwang Won Ju 
Published: January 2023

Purpose
We aimed to investigate the association between dry eye disease (DED) symptoms and mental health among Korean adults in the community.

Methods
A cross-sectional study analyzed the data of 152 participants using mobile-phone applications for recording mental health. We defined individuals with DED symptoms as those who experienced a sense of irritation or dryness of the eye (either constantly or often). Mental health (perceived stress, depression, and anxiety) was assessed using the Perceived Stress Scale, Patient Health Questionnaire-9, and General Anxiety Disorder-7, in this order. Multiple logistic regression analysis was conducted to examine the association between DED symptoms and mental health. We also adjusted for possible covariates. We investigated sex differences in mental health status in relation to DED.

Results
We found that 41.4% of the participants (48.4% female and 30.5% male) showed DED symptoms, and its prevalence was higher in female than in male. The average perceived stress and anxiety symptoms in the female with DED (24.69±4.73 and 6.56±5.09, respectively) were significantly higher than those without DED (21.38±4.68 and 4.54±4.03) (p = 0.020 and 0.038, respectively). Even after adjusting for possible covariates, female who had DED showed higher risks of perceived stress (OR = 1.28), depression (OR = 2.64), and anxiety (OR = 5.81).

Conclusions
Clinicians and nurses should therefore be aware of the possibility of mental health problems among female with DED.
White matter microstructure and receptive vocabulary in children with cerebral palsy: The role of interhemispheric connectivity
Authors: Laporta-Hoyos Olga , Pannek Kerstin , Pagnozzi Alex M. , Fiori Simona , Boyd Roslyn N. 
Published: January 2023

Background
Communication and cognitive impairments are common impediments to participation and social functioning in children with cerebral palsy (CP). Bilateral language networks underlie the function of some high-level language-related cognitive functions.

Purpose
To explore the association between receptive vocabulary and white-matter microstructure in the temporal lobes and the central part of the temporo-temporal bundles in children with CP.

Materials and methods
37 children with spastic motor type CP (mean age 9.6 years, 25 male) underwent a receptive vocabulary test (Peabody Picture Vocabulary Test, PPVT-IV) and 3T MRI. Mean fractional anisotropy (FA) and mean diffusivity (MD) were calculated for the temporal lobes and the interhemispheric bundles traversing the splenium of the corpus callosum and the anterior commissure. Associations between microstructure and receptive vocabulary function were explored using univariable linear regression.

Results
PPVT-IV scores were significantly associated with mean white matter MD in the left temporal lobe, but not the right temporal lobe. There was no association between PPVT-IV and mean white matter FA in the temporal lobes. PPVT-IV scores were not significantly associated with the laterality of these diffusion tensor metrics. Within the corpus callosum, FA, but not MD of the temporo-temporal bundles was significantly associated with the PPVT-IV scores. Within the anterior commissure no equivalent relationship between diffusion metrics and PPVT-IV was found.

Conclusion
Our findings add further understanding to the pathophysiological basis underlying receptive vocabulary skills in children with CP that could extend to other patients with early brain damage. This study highlights the importance of interhemispheric connections for receptive vocabulary.
High tissue expression of TLRs combined with high density of tumor infiltrating lymphocytes predicts a better prognosis in colorectal cancer patients
Authors: Beilmann-Lehtonen Ines , Kasurinen Jussi , Hagström Jaana , Kaprio Tuomas , Böckelman Camilla , Haglund Caj 
Published: January 2023

Background
Colorectal cancer causes 935,000 cancer deaths yearly. High local immune cell infiltration serves as a positive prognostic factor in CRC. Toll-like receptors (TLRs) induce innate immune responses and lead to adaptive immune system activation. TLRs play protumorigenic and antitumorigenic roles. We aimed to explore the relationship between TLR immunoexpressions and the infiltration densities of T-lymphocytes in CRC.

Methods
Immunohistochemical TLR2, TLR4, TLR5, and TLR7 positivity and the density of CD3- and CD8-positive cells in tumoral and stromal tissue were evaluated from the tissue microarray slides of 549 consecutive CRC surgical patients treated at Helsinki University Hospital, Finland, between 1998 and 2005. We calculated the associations and correlations using Pearson’s chi-square and Spearman’s correlation tests, generating survival curves using the Kaplan–Meier method.

Results
Positive intratumoral CD3 and CD8 densities associated with a high TLR2 expression (p < 0.001 and p = 0.001, respectively) and a high TLR4 expression (p = 0.013 and p = 0.025). A low TLR5 immunoexpression associated with negative intratumoral CD3 (p = 0.001) and CD8 (p = 0.011) and a low stromal CD3 (p = 0.001). No association or correlation emerged between TLR7 immunoexpression and CD3 or CD8 cell density. A low CD3–CD8 tumor–stroma index indicated a worse prognosis among all TLR subgroups, except the TLR7-negative subgroup.

Conclusions
We detected significant associations and correlations between high tissue TLR2, TLR4, and TLR5 immunoexpressions and high densities of CD3- and CD8-positive cells. Combining these markers may improve the prognostic evaluation of CRC patients.
Using qualitative interviews to identify patient-reported clinical trial endpoints and analyses that are the most meaningful to patients with advanced breast cancer
Authors: Flood Emuella , Krasnow Anna , Orbegoso Cecilia , Karantzoulis Stella , Bailey Julie , Bayet Solène , Elghouayel Arthur , Foxley Andrew , Sommavilla Roberto , Schiavon Gaia 
Published: January 2023

Background
Designing clinical trials with the emphasis on the patient-centered approach and focusing on clinical outcomes that are meaningful to patients is viewed as a priority by drug developers, regulatory agencies, payers, clinicians, and patients. This study aimed to capture information on clinical trial endpoints that would be most important and relevant for patients with advanced breast cancer, based on patient-reported outcomes.

Methods
Patients with either advanced triple-negative breast cancer [TNBC] and a maximum of two lines of systemic therapy or hormone receptor-positive/human epidermal growth factor receptor 2-negative [HR+/HER2−] breast cancer and a maximum of three lines of systemic therapy, participated in semi-structured concept elicitation interviews. Concept saturation was assessed. A sign, symptom, or impact was defined as “salient” if mentioned by ≥ 60% of participants, with an average bother rating of ≥ 5 (0–10 Scale). Participants were also asked about treatment priorities and to evaluate hypothetical scenarios showing different health-related functioning and quality-of-life treatment outcomes, using graphical representations.

Results
Thirty-two participants (97% women; aged 29+ years) with TNBC (n = 17) or HR+/HER2− breast cancer (n = 15) provided generally similar reports on symptom experience, with fatigue and pain being most salient, though importance of certain treatment-related symptoms varied between the two groups. Patients reported consistent perspectives on the importance of treatment outcomes: when considering a new treatment, they prioritized efficacy of the therapy, acceptable tolerability, stability, predictability of symptoms over time, and the duration of preserved health-related quality of life and physical functioning. The meaningful difference in preserved physical functioning was 2–3 months for 46% of participants with TNBC, whereas for most participants with HR+/HER2− breast cancer it started from 6–7 months. Both groups of participants found it easier to accept some toxicity at the beginning of therapy if it was followed by improvement, as opposed to improvement followed by deterioration.

Conclusion
The results may help to inform the design of patient-centered clinical trials, to interpret health-related quality of life and/or patient-reported outcomes, and to optimize care for patients with advanced breast cancer.