bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pattern recognition of hematological profiles of tumors of the digestive tract: an exploratory study
Authors: Santos-Silva Miguel A. , Sousa Nuno , Majar Marina , Machado Miguel , Reis Joana , Sousa Joao C. 
Published: August 2023

AimsIn this study, we aimed to apply laboratory blood analysis to identify the hematological (based on hemoglobin concentration, erythrocytes, hematocrit, and RDW count) profiles associated with the most prevalent forms of digestive tract malignancies. Furthermore, we aimed to evaluate how these profiles contributed to distinguishing these tumors at diagnosis.MethodsWe collected data from the date of ICD-10 diagnostic coding for C15 esophagus, C16 stomach, C18 colon, and C19 rectum tumors of 184 individuals. The statistical analysis and data visualization approaches, notably the heat map and principal component analysis (PCA), allowed for creating a summary hematological profile and identifying the most associated parameters for each pathologic state. Univariate and multivariate data modeling and ROC analysis were performed in both SPSS and Python.ResultsOur data reveal unique patterns based on tumor development anatomical location, clustering the C18 colon and C19 rectum from the C15 esophagus and C16 stomach. We found a significant difference between C16 stomach carcinoma and the other tumors, which substantially correlated with raised RDW in conjunction with low hemoglobin concentration, erythrocytes, and hematocrit counts. In contrast, C18 colon carcinoma had the higher red blood cell count, allowing for the best classification metrics in the test set of the binary logistic regression (LR) model, accounting for an AUC of 0.77 with 94% sensitivity and 52% specificity.ConclusionThis study emphasizes the significance of adding hematological patterns in diagnosing these malignancies, which could path further investigations regarding profiling and monitoring at the point of care.
Experiences of newly qualified midwives during their transition to practice: a systematic review of qualitative research
Authors: Shi Jinjin , Li Xuemei , Li Yongqi , Liu Ying , Li Junying , Zhang Rongli , Jiang Hui 
Published: August 2023

ObjectiveTo summarize and evaluate the experiences and expectations of newly qualified midwives (NQMs) during their transition from school to clinical practice. One of the main objectives was to provide references for the development of midwifery professional teaching and provide a basis for hospital administrators and instructors of midwifery to develop guidelines and strategies.MethodsA systemic review of qualitative research using meta-aggregation was conducted. We collected studies from 12 databases between inception and February 2023. All qualitative studies published in English and Chinese that reported on the experiences of NQMs during their transition to practice were included. Two independent reviewers assessed the study quality and the credibility of study findings by using the JBI Qualitative Assessment and Review Instrument. The process of searching followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations.ResultsA total of 14 studies were included, and 84 findings were extracted. The results were grouped into 8 new categories and synthesized into 3 main themes: multi-dimensional challenges, physical and emotional responses, and demands and expectations. The included studies were identified to be of good quality and the results of the methodological quality appraisal were all B grade or higher.ConclusionThe transition period is a critical career development for NQMs. However, they faced various stress during the period, which had a negative impact on their physical and mental health. Therefore, it’s important to deeply understand their challenges and needs. And effective management strategies should be implemented, such as in-depth cooperation between hospitals and schools, improvement of the clinical transition support system, enhancement of continuing education, and standardization of the management system. This may be beneficial to improve the quality of clinical midwifery and maintain the stability and sustainable development of the midwifery team.
Regular pulse checks for patients with non-cardioembolic stroke in rehabilitation hospitals to improve recognition and detection of atrial fibrillation (the ESCORT study): protocol for a prospective multicenter observational study
Authors: Katano Takehiro , Suda Satoshi , Ohta Tomohiro , Miyagami Mitsusuke , Kodaira Yuzo , Konaka Chimori , Nagashima Masakazu , Kimura Kazumi 
Published: August 2023

BackgroundCryptogenic stroke (CS) are heterogeneous in origin; however, most CS are embolic mechanism. Paroxysmal atrial fibrillation (AF) is suspected to be a major type of CS that leads to severe cerebral infarction without anticoagulant use. Therefore, the identification of AF is vital in patients with CS. However, patients are often unaware of AF because they have no symptoms, and AF may not be detected on an electrocardiogram (ECG) or Holter ECG on admission. After patients with stroke are treated in the acute phase, they are promptly transferred to a rehabilitation hospital for functional recovery. Once the patient is transferred to a hospital, a few attempts are made to detect AF. In addition, rehabilitation therapists are considered to have insufficient awareness of the possibility of undiagnosed AF.ObjectiveThis study aimed to increase the understanding of the importance of AF detection in patients with ischemic stroke among therapists in rehabilitation hospitals and to investigate whether regular pulse screening can aid in the detection of AF. If AF was detected, we determined the rate and timing of AF detection and identified the patient characteristics.MethodsThis multicenter prospective observational study aimed to detect AF in patients with non-cardiac stroke at rehabilitation hospitals. Therapists performed pulse checks before, during, and after rehabilitation. If arrhythmia or tachycardia was detected, an ECG was performed, and the physician checked for AF. If the patient complained of chest symptoms, electrocardiography (ECG) was performed to check for AF. We investigated the characteristics, laboratory data, cognitive status, complications, such as stroke recurrence, and functional outcomes of patients with AF.ResultsThe study is in the enrollment phase. Recruitment began in September 2022 and will end in August 2023. Patients have provided written informed consent. The main results have been submitted for publication in your journal.ConclusionThe findings of this study will help identify patients with AF in rehabilitation hospitals and improve awareness among therapists.
Comparing effects of beetroot juice and Mediterranean diet on liver enzymes and sonographic appearance in patients with non-alcoholic fatty liver disease: a randomized control trials
Authors: Fateh Hawal Lateef , Rashid Sameeah Abdulrahman , Muhammad Sarmad S. , Al-Jaf Sabah H. , Ali Ayad M. 
Published: August 2023

BackgroundIn both developed and developing countries, non-alcoholic fatty liver disease (NAFLD) has lately risen to the top of the list of chronic liver illnesses. Although there is no permanent cure, early management, diagnosis, and treatment might lessen its effects. The purpose of conducting the current study is to compare the effects of beetroot juice and the Mediterranean diet on the lipid profile, level of liver enzymes, and liver sonography in patients with NAFLD.MethodsIn this randomized controlled trial, 180 people with a mean age of (45.19 ± 14.94) years participated. Participants ranged in age from 19 to 73. The mean weight before intervention was (82.46 ± 5.97) kg, while the mean weight after intervention was roughly (77.88 ± 6.26) kg. The trial lasted for 12 weeks. The participants were split into four groups: control, a Mediterranean diet with beet juice (BJ + MeD), Mediterranean diet alone (MeD), and beetroot juice (BJ). The Mediterranean diet included fruits, vegetables, fish, poultry, and other lean meats (without skin), sources of omega-3 fatty acids, nuts, and legumes. Beetroot juice had 250 mg of beetroot. Data analysis was done using SPSS software (version 26.0). p &lt; 0.05 is the statistical significance level.ResultsFollowing the intervention, Serum Bilirubin, alkaline phosphatase (ALP), alanine transaminase (ALT), serum cholesterol (CHOL), triglyceride (TG), and low-density lipoprotein (LDL) levels were significantly decreased in the BJ + MeD, BJ, and MeD groups (p = 0.001). Also, high-density lipoprotein (HDL) significantly increased in the BJ + MeD, BJ, and MeD groups (p = 0.001), while decreasing in the Control group (p = 0.001).ConclusionThe research findings indicate a significant reduction in hepatic steatosis among the groups receiving beetroot juice (BJ) and beetroot juice combined with the Mediterranean diet (BJ + MeD). This suggests that beetroot juice holds potential as an effective treatment for non-alcoholic fatty liver disease (NAFLD) in adults. Furthermore, the combination of beetroot juice with the Mediterranean diet showed enhanced efficacy in addressing NAFLD.Clinical trial registration:ClinicalTrials.gov, identifier NCT05909631.
Impact of multidisciplinary team on the pattern of care for brain metastasis from breast cancer
Authors: Xu Fei , Ou Dan , Qi Weixiang , Wang Shubei , Han Yiming , Cai Gang , Cao Lu , Xu Cheng , Chen Jia-Yi 
Published: August 2023

PurposeThe aim of this study was to explore how a multidisciplinary team (MDT) affects patterns of local or systematic treatment.MethodsWe retrospectively reviewed the data of consecutive patients in the breast cancer with brain metastases (BCBM) database at our institution from January 2011 to April 2021. The patients were divided into an MDT group and a non-MDT group.ResultsA total of 208 patients were analyzed, including 104 each in the MDT and non-MDT groups. After MDT, 56 patients (53.8%) were found to have intracranial “diagnosis upgrade”. In the matched population, patients in the MDT group recorded a higher proportion of meningeal metastases (14.4% vs. 4.8%, p = 0.02), symptomatic tumor progression (11.5% vs. 5.8%, p = 0.04), and an increased number of occurrences of brain metastases (BM) progression (p &lt; 0.05). Attending MDT was an independent factor associated with ≥2 courses of intracranial radiotherapy (RT) [odds ratio (OR) 5.4, 95% confidence interval (CI): 2.7–10.9, p &lt; 0.001], novel RT technique use (7.0, 95% CI 3.5–14.0, p &lt; 0.001), and prospective clinical research (OR 5.7, 95% CI 2.4–13.4, p &lt; 0.001).ConclusionPatients with complex conditions are often referred for MDT discussions. An MDT may improve the qualities of intracranial RT and systemic therapy, resulting in benefits of overall survival for BC patients after BM. This encourages the idea that treatment recommendations for patients with BMBC should be discussed within an MDT.
Impact of the time interval between primary or interval surgery and adjuvant chemotherapy in ovarian cancer patients
Authors: Farolfi Alberto , Petracci Elisabetta , Gurioli Giorgia , Tedaldi Gianluca , Casanova Claudia , Arcangeli Valentina , Amadori Andrea , Rosati Marta , Stefanetti Marco , Burgio Salvatore Luca , Cursano Maria Concetta , Lolli Cristian , Zampiga Valentina , Cangini Ilaria , Schepisi Giuseppe , De Giorgi Ugo 
Published: August 2023

IntroductionPrimary debulking surgery (PDS), interval debulking surgery (IDS), and platinum-based chemotherapy are the current standard treatments for advanced ovarian cancer (OC). The time to initiation of adjuvant chemotherapy (TTC) could influence patient outcomes.MethodsWe conducted a multicenter retrospective cohort study of advanced (International Federation of Gynecology and Obstetrics (FIGO) stage III or IV) OC treated between 2014 and 2018 to assess progression-free survival (PFS) and overall survival (OS) in relation to TTC. All patients underwent a germline multigene panel for BRCA1/2 evaluation.ResultsAmong the 83 patients who underwent PDS, a TTC ≥ 60 days was associated with a shorter PFS (hazard ratio (HR) 2.02, 95% confidence interval (CI) 1.04–3.93, p = 0.038), although this association lost statistical significance when adjusting for residual disease (HR 1.52, 95% CI 0.75–3.06, p = 0.244, for TTC and HR 2.73, 95% CI 1.50–4.96, p = 0.001, for residual disease). Among 52 IDS patients, we found no evidence of an association between TTC and clinical outcomes. Ascites, type of chemotherapy, or germline BRCA1/2 mutational status did not influence TTC and were not associated with clinical outcomes in PDS or IDS patients.DiscussionIn conclusion, longer TTC seems to negatively affect prognosis in patients undergoing PDS, especially those with residual disease.
Long-term outcomes of an internet-delivered cognitive enhancement intervention targeting residual cognitive deficits after major depressive disorder: a 2-year follow-up of an open trial
Authors: Myklebost Sunniva Brurok , Nordgreen Tine , Klakegg Oda Stakkestad , Hammar Åsa 
Published: August 2023

BackgroundCognitive deficits are common and disabling residual symptoms following major depressive disorder (MDD) and are related to increased risk of relapse. Residual cognitive deficits should thus be considered an important target for treatment. However, few have reported long-term outcomes of interventions targeting residual cognitive deficits.ObjectiveThis study aimed to (1) investigate change between pre-treatment and 2-year follow-up assessments in cognitive deficits, rumination, and symptoms of MDD after an internet-delivered intervention targeting residual cognitive deficits; (2) to investigate stability in outcomes between 6-month and 2-year follow-up assessments; (3) to report the number of participants’ experiencing a new episode of MDD in the follow-up period; and (4) to investigate differences in outcomes between those who experienced a new episode of MDD and those who did not.MethodsA total of 43 partly remitted adults were included to test a guided internet-delivered intervention, which consisted of 10 modules involving psychoeducation, cognitive strategies, and attention training. Participants were assessed at pre-treatment, post-treatment, after 6-months, and after 2-years, with measures assessing self-reported residual cognitive deficits, rumination, symptoms of MDD and relapse. Overall, 32 participants completed the 2-year follow-up assessment.ResultsBetween the pre-treatment and 2-year follow-up assessments, there was a reduction in cognitive deficits and rumination, while there was an increase in symptoms of MDD. Cognitive deficits were stable between the 6-month and the 2-year follow-up, while there was an increase in rumination and symptoms of MDD. Thirteen of 32 participants reported a new episode of MDD during the follow-up period. The relapse group reported longer duration of MDD at pre-treatment and showed a difference in all outcomes after 2 years compared to the no-relapse group. The no-relapse group showed improvement in MDD symptoms at post-treatment, while the relapse group did not.ConclusionDelivering cognitive enhancement interventions over the internet is potentially related to stable improvements in residual cognitive deficits. The effects on rumination and symptoms of MDD are less certain. Lack of improvement in MDD symptoms after the intervention period should be investigated as an indicator of relapse. Results should be interpreted with caution due to the lack of control group and sample size.
Direct medical cost of COVID-19 in children hospitalized at a tertiary referral healthcare center in Mexico City
Authors: Reyes-López Alfonso , Jimenez-Juárez Rodolfo Norberto , Salinas-Escudero Guillermo , Avilés-Robles Martha Josefina , Martínez-Valverde Silvia , Granados-García Víctor , Garduño-Espinosa Juan 
Published: August 2023

IntroductionDespite the end of the COVID-19 pandemic being declared by the WHO, the economic consequences are far from over. One of these implications was the cost of inpatient care for health institutions. To date, some studies have examined the economic burden of COVID-19 in the adult population but only a few have focused on child populations.ObjectiveTo estimate the direct medical costs of COVID-19, focusing on children in Mexico.MethodData about resources consumed during hospital stays were extracted from the medical records of patients hospitalized at a Mexican tertiary healthcare institution. Other sources of information were the unit prices of inputs and the salaries of health personnel. A micro-costing methodology was used to obtain cost results by age group over different hospital areas. Data analysis was performed with descriptive statistics and regression models to evaluate the predictors of total cost.ResultsOne hundred and ten medical records were reviewed of which 57.3% corresponded to male patients and the mean age was 7.2 years old. The estimated average cost per patient was US$5,943 (95% CI: US$4,249–7,637). When the costs of the three clinical areas were summed, only the 5–10 years old group showed a maximum cost of US$14,000. The regression analysis revealed the following factors as significant: sex, age, staying at an emergency room, having a positive bacterial culture, and having comorbidities.DiscussionThe cost results were somewhat similar to those reported in children from the USA, but only regarding low severity COVID-19 cases. However, comparability between these types of studies should be done with caution due to the huge differences between the healthcare systems of countries. The study cost results may help public decision-makers in budget planning and as inputs for future cost-effectiveness studies about interventions regarding COVID-19.
Early-life adversity and later-life mental health: a conditional process analysis of sense of coherence and resilience-related resources
Authors: Rohner Shauna L. , Bernays Florence , Maercker Andreas , Thoma Myriam V. 
Published: August 2023

ObjectiveWhile early-life adversity can have negative effects on health and wellbeing that persist across the lifespan, some individuals show indications of resilience. Resilience can be understood as a dynamic coping process involving the mobilization of resources in response to adversity exposure. Sense of coherence—revised (SOC-R), an ability linked to health maintenance in the face of adversity, may be influential in this process. However, research is lacking on the mechanisms underpinning SOC-R and resilience-related resources and their impact on the (mental) health of individuals exposed to early-life adversity. Therefore, this study examined the role of SOC-R and selected resilience-related resources in the relationship between early-life adversity and later-life health and wellbeing.MethodParticipants were N = 531 Irish (older) adults (58.2% female, mean age = 59.5 years, range = 50–86 years). Standardized questionnaires assessed retrospective reports of early-life adversity, as well as current physical and mental health, satisfaction with life, SOC-R, and resilience-related resources (self-efficacy, optimism, social support). A multiple mediation analysis tested the indirect effects of the resources and a moderated mediation tested for conditional dependence on SOC-R.ResultsFor mental health and satisfaction with life, significant partial mediations were found for all three resources. Only optimism showed a significant partial mediation for physical health. In the moderated mediation, SOC-R significantly moderated the associations between early-life adversity and self-efficacy (b = .06, t = 3.65, p = .001), optimism (b = .04, t = 2.60, p = .009), and social support (b = .08, t = 3.75, p &lt; .001). The indirect effects were larger at high rather than low SOC-R, indicating that the mediating effects of the resources were greater for individuals with a stronger SOC-R.ConclusionA strong SOC-R may have a beneficial influence on health and wellbeing by mitigating the detrimental effect of early-life adversity on the resources self-efficacy, optimism, and social support. Future avenues for research include the expanded assessment of resources and the potential role of SOC-R in successful ageing through the selection and adaptation of goals and resources into older age. SOC-R may represent a promising target for psychotherapeutic interventions promoting resilience in survivors of early-life adversity.
On the super-junction formed by using field plate for lateral AlGaN/GaN-based Schottky barrier diodes
Authors: Wang Zhizhong , Huang Fuping , Chu Chunshuang , Zhang Yonghui , Sun Qian , Zhang Zi-Hui 
Published: August 2023

Abstract
In this work, by using numerical TCAD simulations, we have systematically studied the impact of different field plates (FPs) on the electrical characteristics for lateral AlGaN/GaN-based Schottky barrier diodes (SBDs) with recessed anode. The FP enables the formation of a super-junction. When compared with the reference device without a FP, the proposed SBDs can generate charge-coupling effect between the FP and the recessed anode region, which can effectively reduce the electric field magnitude at the metal/sidewall interface. We also find that the electric field profiles can be affected by the FP length, insulation layer thickness and different insulation materials with various dielectric constants. By doing so, we can enhance the breakdown voltage by homogenizing the electric field distribution in the GaN drift layer. Then, the electric field at the recessed anode region can be decreased and the GaN drift layer can be extensively depleted.
The Kiloparsec-scale Influence of the AGN in NGC 1068 with SALT RSS Fabry–Pérot Spectroscopy*
Authors: Hviding Raphael E. , Hickox Ryan C. , Väisänen Petri , Ramphul Rajin , Hainline Kevin N. 
Published: August 2023

Abstract
We present Fabry–Pérot (FP) imaging and longslit spectroscopy of the nearby Seyfert II galaxy NGC 1068 using the Robert Stobie Spectrograph (RSS) on the Southern African Large Telescope (SALT) to observe the impact of the central active galactic nucleus (AGN) on the ionized gas in the galaxy on kiloparsec scales. With SALT RSS FP we are able to observe the Hα + [N ii] emission line complex over a ∼2.6 arcmin2 field of view. Combined with the longslit observation, we demonstrate the efficacy of FP spectroscopy for studying nearby Type II Seyfert galaxies and investigate the kiloparsec-scale ionized gas in NGC 1068. We confirm the results of previous work from the TYPHOON/Progressive Integral Step Method survey that the kiloparsec-scale ionized features in NGC 1068 are driven by AGN photoionization. We analyze the spatial variation of the AGN intensity to put forward an explanation for the shape and structure of the kiloparsec-scale ionization features. Using a toy model, we suggest the ionization features may be understood as a light echo from a burst of enhanced AGN activity ∼2000 yr ago.