bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemical analysis, antioxidant capacities, and in vitro biological activities of the extract of seed coat as by-products of pea
Authors: Gazwi Hanaa S. S. , Omar Maha O. A. , Mahmoud Magda E. 
Published: February 2023

AbstractConverting seed coat peas (hulls) (SCP) into beneficial products provides a solution for waste treatment. This study aimed to investigate the phytoconstituents and biological activities of SCP extract. Phytochemical screening, total bioactive compounds, and GC–MS analysis were evaluated. Then, the antioxidant, antibacterial, anticancer, and antiviral activities of SCP extract were determined. The results demonstrate that SCP extract has bioactive compounds such as carbohydrates (29.53 ± 4.23 mg/mL), protein (0.24 ± 0.02 mg/mL), phenolics (27.04 ± 0.94 mg GAE/g extract), and flavonoids (17.19 ± 0.48 mg QE/g extract). The existence of more than 16 substances was determined using GC–MS analysis. The extract showed potential antioxidant activities, with the maximum activity seen for extract (IC50 µg/mL) = 79.16 ± 1.77 for DPPH, 67.40 ± 5.20 for ORAC, and 61.22 ± 4.81 for ABTS assays. The SCP extract showed potent antimicrobial activity against four gram-positive bacteria (Bacillus cereus, Streptomyces sp., Staphylococcus aureus, and Salmonella sp.) and two gram-negative bacteria (Escherichia coli and Pseudomonas sp.). SCP extract exhibited potential anticancer activity against lymphoma U937 and leukemic cells (THP1). The extract exhibited potential antiviral activity, with a selectivity index (SI) equal to 11.30 and 18.40 against herpes simplex-II (HSV-2) and adenovirus (Ad7), respectively. The results demonstrate more accurate information about peas by-products' chemical and antioxidant activities in various applications. The chemical components of peas by-products were found to have an in vitro antioxidant, antibacterial, and antiviral activity against leukemia and lymphoma.
Documenting cannabis use in primary care: a descriptive cross-sectional study using electronic medical record data in Alberta, Canada
Authors: Soos Boglarka , Garies Stephanie , Cornect-Benoit Ashley , Montgomery Lori , Sharpe Heather , Rittenbach Katherine , Manca Donna , Duerksen Kimberley , Forst Brian , Drummond Neil 
Published: February 2023

Abstract
Objective
Documenting cannabis use is important for patient care, but no formal requirements for consistent reporting exist in primary care. The objective of this study was to understand how cannabis use is documented in primary care electronic medical record (EMR) data.

Results
This was a cross-sectional study using de-identified EMR data from over 398,000 patients and 333 primary care providers in Alberta, Canada. An automated pattern-matching algorithm was developed to identify text and ICD-9 diagnostic codes indicating cannabis use in the EMR. There was a total of 11,724 records indicating cannabis use from 4652 patients, representing approximately 1.2% of the patient sample. Commonly used terms and ICD-9 codes included cannabis, marijuana/marihuana, THC, 304.3 and 305.2. Nabilone was the most frequently prescribed cannabinoid medication. Slightly more males and those with a chronic condition had cannabis use recorded more often. Overall, very few patients have cannabis use recorded in primary care EMR data and this is not captured in a systematic way. We propose several strategies to improve the documentation of cannabis use to facilitate more effective clinical care, research, and surveillance.
Systematic review with radiomics quality score of cholangiocarcinoma: an EuSoMII Radiomics Auditing Group Initiative
Authors: Cannella Roberto , Vernuccio Federica , Klontzas Michail E. , Ponsiglione Andrea , Petrash Ekaterina , Ugga Lorenzo , Pinto dos Santos Daniel , Cuocolo Renato 
Published: February 2023

Abstract
Objectives
To systematically review current research applications of radiomics in patients with cholangiocarcinoma and to assess the quality of CT and MRI radiomics studies.

Methods
A systematic search was conducted on PubMed/Medline, Web of Science, and Scopus databases to identify original studies assessing radiomics of cholangiocarcinoma on CT and/or MRI. Three readers with different experience levels independently assessed quality of the studies using the radiomics quality score (RQS). Subgroup analyses were performed according to journal type, year of publication, quartile and impact factor (from the Journal Citation Report database), type of cholangiocarcinoma, imaging modality, and number of patients.

Results
A total of 38 original studies including 6242 patients (median 134 patients) were selected. The median RQS was 9 (corresponding to 25.0% of the total RQS; IQR 1–13) for reader 1, 8 (22.2%, IQR 3–12) for reader 2, and 10 (27.8%; IQR 5–14) for reader 3. The inter-reader agreement was good with an ICC of 0.75 (95% CI 0.62–0.85) for the total RQS. All studies were retrospective and none of them had phantom assessment, imaging at multiple time points, nor performed cost-effectiveness analysis. The RQS was significantly higher in studies published in journals with impact factor > 4 (median 11 vs. 4, p = 0.048 for reader 1) and including more than 100 patients (median 11.5 vs. 0.5, p < 0.001 for reader 1).

Conclusions
Quality of radiomics studies on cholangiocarcinoma is insufficient based on the radiomics quality score. Future research should consider prospective studies with a standardized methodology, validation in multi-institutional external cohorts, and open science data.
MRI of diffuse-type tenosynovial giant cell tumour in the knee: a guide for diagnosis and treatment response assessment
Authors: Spierenburg Geert , Suevos Ballesteros Carlos , Stoel Berend C. , Navas Cañete Ana , Gelderblom Hans , van de Sande Michiel A. J. , van Langevelde Kirsten 
Published: February 2023

AbstractTenosynovial giant cell tumour (TGCT) is a rare soft-tissue tumour originating from synovial lining of joints, bursae and tendon sheaths. The tumour comprises two subtypes: the localised-type (L-TGCT) is characterised by a single, well-defined lesion, whereas the diffuse-type (D-TGCT) consists of multiple lesions without clear margins. D-TGCT was previously known as pigmented villonodular synovitis. Although benign, TGCT can behave locally aggressive, especially the diffuse-type. Magnetic resonance imaging (MRI) is the modality of choice to diagnose TGCT and discriminate between subtypes. MRI can also provide a preoperative map before synovectomy, the mainstay of treatment. Finally, since the arrival of colony-stimulating factor 1-receptor inhibitors, a novel systemic therapy for D-TGCT patients with relapsed or inoperable disease, MRI is key in assessing treatment response. As recurrence after treatment of D-TGCT occurs more often than in L-TGCT, follow-up imaging plays an important role in D-TGCT. Reading follow-up MRIs of these diffuse synovial tumours may be a daunting task. Therefore, this educational review focuses on MRI findings in D-TGCT of the knee, which represents the most involved joint site (approximately 70% of patients). We aim to provide a systematic approach to assess the knee synovial recesses, highlight D-TGCT imaging findings, and combine these into a structured report. In addition, differential diagnoses mimicking D-TGCT, potential pitfalls and evaluation of tumour response following systemic therapies are discussed. Finally, we propose automated volumetric quantification of D-TGCT as the next step in quantitative treatment response assessment as an alternative to current radiological assessment criteria.
Review on the methodology to assess respiratory tract lesions in pigs and their production impact
Authors: Maes Dominiek , Sibila Marina , Pieters Maria , Haesebrouck Freddy , Segalés Joaquim , de Oliveira Luís Guilherme 
Published: February 2023

AbstractPorcine respiratory disease is one of the most important health problems in pig production worldwide. Cranioventral pulmonary consolidation (CVPC) and pleurisy are the two most common lesions in the respiratory tract of slaughtered pigs. The present review paper discusses pathogens involved in the lesions, lesion prevalence, scoring systems, advantages and disadvantages of slaughterhouse examination, and the impact of CVPC and pleurisy on performance, carcass, and meat quality. Cranioventral pulmonary consolidation and pleurisy in slaughter pigs are characteristic for infections withMycoplasma hyopneumoniaeandActinobacillus pleuropneumoniae, respectively, although other pathogens may cause similar lesions and/or be involved in their development. The overall prevalence of CVPC and pleurisy in slaughter pigs are still high, being the prevalence of CVPC generally higher than that of chronic pleurisy. The advantages and disadvantages of slaughterhouse examination are discussed in relation to practical aspects, the assessment of lesions, the number and representativeness of the examined animals and the interpretation and value of the results for the stakeholders. The main scoring methods for CVPC and pleurisy are shortly reviewed. In general, scoring methods can be applied rapidly and easily, although significant variation due to abattoir and observer remains. Artificial intelligence-based technologies that automatically score lesions and facilitate processing of data may aid solving these problems. Cranioventral pulmonary consolidation and pleurisy have a major negative impact on pig performance, and the effects increase the extension of the lesions and/or presence of multiple lesions. The performance losses caused by these lesions, however, vary significantly between studies and farms, possibly due to differences in study population and used methodology. Both lesions also have a negative impact on different carcass and meat quality parameters, leading to increased risk for poor processing and storage of the carcasses. Monitoring lung lesions of slaughter pigs should be optimized and implemented routinely; however, it is recommended to complement this information with farm data and laboratory results for specific pathogens.
Convergence theorems for total asymptotically nonexpansive mappings in $\operatorname{CAT} (\kappa )$ spaces
Authors: Chang Shih-sen , Zhao Liangcai , Liu Min , Tang Jinfang 
Published: February 2023

AbstractThe purpose of this paper is to study the convergence theorems in$\operatorname{CAT} (\kappa )$CAT(κ)spaces with$k > 0$k>0fortotal asymptotically nonexpansive mappingswhich are essentially wider than nonexpansive mappings, asymptotically nonexpansive mapping, and asymptotically nonexpansive mappings in the intermediate sense. Our results generalize, unify, and improve several comparable results in the existing literature.
Incarcerated left-sided Amyand’s hernia and synchronous ipsilateral femoral hernia: first case report
Authors: Corvatta Franco A. , Palacios Huatuco René M. , Bertone Santiago , Viñas José F. 
Published: February 2023

Abstract
Background
The finding of a vermiform appendix within the peritoneal sac of an inguinal hernia is called Amyand’s hernia. The reported incidence of Amyand’s hernia and femoral hernia is 1% and 3.8%, respectively. To our knowledge, no cases have been reported in the literature that associate these two entities. We present the first case of incarcerated left-sided Amyand’s hernia and synchronous ipsilateral femoral hernia found during emergency surgery.

Case presentation
A 72-year-old woman was admitted to the Emergency Department for a complicated left inguinal hernia. An inguinotomy was performed that detected a large direct hernial sac and a synchronous femoral hernia. The opening of the inguinal hernia showed the presence of the cecum and the appendix, both without signs of inflammation. The femoral space was evaluated transinguinally, identifying the larger omentum that had slipped into the femoral canal. The primary closure of the posterior wall defect was performed with the McVay technique due to its large size, and then the hernioplasty was completed with a polypropylene mesh. No postoperative complications were reported.

Conclusions
In the context of an incarcerated Amyand’s hernia, the decision to perform an appendectomy in addition to hernia repair with or without mesh will depend on intraoperative findings.
Switching to brolucizumab: injection intervals and visual, anatomical and safety outcomes at 12 and 18 months in real-world eyes with neovascular age-related macular degeneration
Authors: Coney Joseph M. , Zubricky Ryan , Sinha Samriddhi Buxy , Sonbolian Nina , Zhou Lujia , Hull Thomas P. , Lewis Shawn A. , Miller David G. , Novak Michael A. , Pendergast Scott D. , Pham Hang , Platt Sean M. , Rao Llewelyn J. , Schartman Jerome P. , Singerman Lawrence J. , Donkor Richard , Fink Margaret , McCoy Jasmyne , Karcher Helene 
Published: February 2023

Abstract
Background
The anti-vascular endothelial growth factor (anti-VEGF) injection interval influences treatment burden and compliance in neovascular age-related macular degeneration (nAMD). This real-world study investigates visual acuity (VA), injection-interval extension, central macular thickness (CMT) and safety in nAMD eyes switched to the anti-VEGF agent brolucizumab and followed for up to 18 months.

Methods
This retrospective study included patients with nAMD who were switched from other anti-VEGF agents to brolucizumab only. Patient eyes were grouped into three nested cohorts with the overall cohort receiving ≥ 1 brolucizumab injection, the second receiving ≥ 3 brolucizumab injections with a follow-up period of ≥ 12 months and the third cohort receiving ≥ 3 brolucizumab injections with a follow-up period of ≥ 18 months. Study endpoints included changes from baseline at 12 or 18 months in VA, injection intervals, and CMT. Sub-group analyses were conducted using baseline injection interval length or baseline VA as qualifiers.

Results
Overall, 482 eyes received ≥ 1 brolucizumab injection; 174 eyes received ≥ 3 brolucizumab injections with ≥ 12 months of follow-up, and 95 eyes received ≥ 3 brolucizumab injections with ≥ 18 months of follow-up. VA (mean [95% confidence intervals]) remained stable relative to baseline after 12 months (− 1.1 [− 3.7, 1.6] letters; p = 0.42) and 18 months (0.0 [− 3.1, 3.1] letters; p = 0.98) of brolucizumab treatment, respectively, and pre-switch injection intervals or baseline VA had no notable effect. Following the switch to brolucizumab, injection intervals were extended from baseline to month 12 by 26.9 (19.7, 34.0) days (p < 0.0001), and eyes with pre-switch injection intervals < 8 weeks were able to have their injection intervals extended by 23.6 days longer than eyes with pre-switch injection intervals ≥ 8 weeks. At 18 months, injection intervals were extended by 36.3 (25.6, 46.9) days (p < 0.0001) compared to baseline. Following switch to brolucizumab, CMT was reduced at both 12 and 18 months (12 months: − 35.2 (− 51.7, − 18.8) µm, p < 0.0001; 18 months: − 38.9 (− 54.3, − 22.0) µm, p < 0.0001). Intraocular inflammation-related adverse events were reported in 4.6% of brolucizumab-treated eyes.

Conclusions
This real-world study demonstrates that injection intervals may be significantly extended with maintained vision and reduced CMT in nAMD eyes switching to brolucizumab therapy from other anti-VEGFs.
Object recognition ability predicts category learning with medical images
Authors: Smithson Conor J. R. , Eichbaum Quentin G. , Gauthier Isabel 
Published: February 2023

AbstractWe investigated the relationship between category learning and domain-general object recognition ability (o). We assessed this relationship in a radiological context, using a category learning test in which participants judged whether white blood cells were cancerous. In study 1, Bayesian evidence negated a relationship between o and category learning. This lack of correlation occurred despite high reliability in all measurements. However, participants only received feedback on the first 10 of 60 trials. In study 2, we assigned participants to one of two conditions: feedback on only the first 10 trials, or on all 60 trials of the category learning test. We found strong Bayesian evidence for a correlation between o and categorisation accuracy in the full-feedback condition, but not when feedback was limited to early trials. Moderate Bayesian evidence supported a difference between these correlations. Without feedback, participants may stick to simple rules they formulate at the start of category learning, when trials are easier. Feedback may encourage participants to abandon less effective rules and switch to exemplar learning. This work provides the first evidence relating o to a specific learning mechanism, suggesting this ability is more dependent upon exemplar learning mechanisms than rule abstraction. Object-recognition ability could complement other sources of individual differences when predicting accuracy of medical image interpretation.
Investigating the presence of mathematics and the levels of cognitively demanding mathematical tasks in integrated STEM units
Authors: Forde Elizabeth N. , Robinson Latanya , Ellis Joshua A. , Dare Emily A. 
Published: February 2023

AbstractEffective K-12 integrated STEM education should reflect an intentional effort to adequately represent and facilitate each of its component disciplines in a meaningful way. However, most research in this space has been conducted within the context of science classrooms, ignoring mathematics. Also missing from the literature is research that examines the level of cognitive demand required from mathematical tasks present within integrated STEM lessons. In order to seek insight pertaining to this gap in the literature, we sought to better understand how science teachers use mathematics within K-12 integrated STEM instruction. We used an explanatory sequential mixed methods research design to explore the enactment of mathematics in integrated STEM lessons that focus on physical, earth, and life science content. We first examined 2030 sets of video-recorded classroom observation scores generated from the 10-item STEM Observation Protocol (STEM-OP) designed for observing integrated STEM education in K-12 classrooms. We compared the STEM-OP scores of classroom observations that included mathematics with those that did not. This quantitative analysis was followed by a closer, more in-depth qualitative examination of how mathematics was employed, focusing on the degree of cognitive demand. To do this, we coded and analyzed transcripts from video-recorded classroom observations in which mathematical content was present. Our study yielded two main findings about mathematics in integrated STEM lessons: (1) the presence of mathematical content resulted in higher STEM-OP scores on nearly all items, and (2) mathematical tasks within these lessons were categorized as requiring mainly low levels of cognitive demand from students. This study highlights the need for the increased inclusion of mathematical tasks in integrated STEM teaching. Implications for including higher-order mathematical thinking within integrated STEM teaching are discussed.
Comparison of maximum intensity projection and volume rendering on multidetector computed tomography in detecting pulmonary nodules
Authors: Kolta Marian Fayek Farid , Higo Noura Mahmoud , Mohamed Inas Abdou , Abd El-Mageed Mohammed Raafat 
Published: February 2023

Abstract
Background
Lung cancer is the one of the most common types of cancer and considered as a leading cause of death from neoplasms. Almost all types of lung cancer develop from pulmonary nodules. The wide availability of the multi-detector computed tomography (MDCT) scanners makes the detection of pulmonary nodules much easier. Volume rendering (VR) and maximum intensity projection (MIP) techniques are the most commonly used post-processing techniques. The purpose of this research is to compare and contrast the two techniques in terms of the number and size of nodules.

Results
In the current study, 32 patients with pulmonary nodules were included being referred from the chest department, with their age ranging from 27 to 71 years old. Nodules characteristics, such as number and size, were evaluated on both MIP and VR techniques. Paired comparison of number of pulmonary nodules less than 6 mm between MIP and VR showed statistically significant difference in 4, 7 and 10 mm slip thickness with P-value 0.003, 0.0001 and 0.0001, respectively. Paired comparison of number of pulmonary nodules more than 6 mm in size between MIP and VR showed no statistically significant difference in 4, 7 and 10 mm slip thickness with P-value > 0.05 each. Comparison of the pulmonary nodules numbers according to slip thickness showed that there was a statistically significant difference in the number of detected nodules, showing that 10 mm slip thickness is significantly higher compared to 4 mm and 7 mm with P-value 0.0001, 0.0001 for nodules < 6 mm, and 0.001 for the lung nodules > 6 mm in size.

Conclusions
We can conclude the superiority of MIP over VR in detection of small sized nodules. MIP was easier to follow and showed high inter-reader agreement. The 10 mm MIP outperformed all other slab thicknesses for nodule detection less than 6 mm. There was no statistically significant difference between both techniques in terms of larger nodules measuring > 6 mm.
Phase-contrast magnetic resonance imaging in evaluation of hydrocephalus in pediatric patients
Authors: El-Sayed Sakr Gehad Ahmed , Hamisa Manal Fathy , El Sawaf Yasser Fouad , Nagy Hanan Ahmad 
Published: February 2023

Abstract
Background
Hydrocephalus is an increase in cerebrospinal fluid volume leading to cerebral ventricular enlargement (ventriculomegaly). Phase-contrast magnetic resonance imaging is a sensitive technique to cerebrospinal fluid flow allowing noninvasive quantitative and qualitative evaluation of cerebrospinal fluid flow.

Aim
The purpose of our study was to assess the role of cerebrospinal fluid flowmetry using phase-contrast magnetic resonance imaging in evaluation of hydrocephalus in pediatric patients.

Methods
This prospective study included a group of 50 patients with ventriculomegaly diagnosed by a previous magnetic resonance imaging study. A control group of 20 subjects of matched age group were also included. All the participants were subjected to cerebrospinal fluid flow study.

Results
After quantitative assessment of cerebrospinal fluid flow at aqueduct level, the mean values of flow and velocity parameters were compared in both patients and control groups. The mean values in patients with aqueduct stenosis and Dandy–Walker malformation were significantly lower than those of the control group (no flow with hypodynamic circulation) with p < 0.001, < 0.017 for mean velocity, respectively, the mean values in patients with brain atrophy and Arnold–Chiari malformation, bilateral obstructive hydrocephalus at foramen of Monro were significantly lower than those of the control group (diminished flow with hypodynamic circulation) with p < 0.001, < 0.001, 0.046 for mean velocity, respectively, and 0.002, 0.001, 0.160 for stroke volume, respectively, the mean values in patients with communicating hydrocephalus and unilateral obstructive hydrocephalus at foramen of Monro were significantly higher than those of the control group (hyperdynamic flow) with p < 0.001 for mean velocity and stroke volume, and the mean values in patients with arachnoid cysts were within normal as compared to control group (normal dynamic flow).

Conclusion
Phase-contrast magnetic resonance imaging is a noninvasive technicality used for evaluation of cerebrospinal fluid flow both qualitatively and quantitatively for determining the type of hydrocephalus seen.