bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation into the development of novel lanthanide‐based luminescent colorants for application to textiles and paper materials
Authors: Lewis D. M. , Broadbent P. J. , Rigout M. L. A. , Carr C. M. , Seaton C. C. , Swift T. 
Published: February 2023

AbstractThis article describes the synthesis and application of lanthanide‐based luminophores for visualisation under short wavelength ultraviolet (UV) activation (typically 254 nm). Luminophores are chemical compounds which re‐emit light of longer wavelength than typical fluorescence and phosphorescence, following photoexcitation, because of efficient energy transfer from the ligands to the lanthanide ion emission levels. The luminophores described in this article are all derived from europium and terbium metal complexes and cover the complete colour gamut. Selection of appropriate ligands allows for water solubility or water insolubility (if required pigment or disperse “dye” applications). Similar to dyeing or printing processes, the anionic complexes can be applied to polyamide fibres or to cellulosic fibres, whereas dispersions of the non‐ionic complexes are suitable for polyester or cellulose acetate fibre application. The water‐soluble derivatives are also suitable for ink‐jet printing and the water‐insoluble derivatives are suitable for lithographic or intaglio paper printing. The novel complexes are excited by radiation below 300 nm and thus cannot be activated by sunlight (the earth's atmosphere prevents light below about 300 nm reaching the surface). Accordingly, the photo‐stability of the dyed materials and prints obtained is excellent. These materials could be used in security marking applications, for example bank‐notes and passports, where they could replace the current fluorophores that are rendered visible under near UV light (typically 365 nm) illumination but exhibit relatively poor photo‐stability. The development of an RGB (red, green and blue) colour palette for inkjet printing based on these innovative luminophores will significantly support the design of digitally printed security features.
S3 Guideline Urticaria. Part 2: Treatment of urticaria – German‐language adaptation of the international S3 guideline
Authors: Zuberbier Torsten , Altrichter Sabine , Bauer Sabine , Brehler Randolf , Brockow Knut , Dressler Corinna , Fluhr Joachim , Gaskins Matthew , Hamelmann Eckard , Kühne Kathrin , Merk Hans , Mülleneisen Norbert K. , Nast Alexander , Olze Heidi , Ott Hagen , Pleimes Marc , Ruëff Franziska , Staubach‐Renz Petra , Wedi Bettina , Maurer Marcus 
Published: February 2023

SummaryThis publication is the second part of the German‐language S3 guideline on urticaria. It covers the management of urticaria and should be used together withPart 1of the guideline on classification and diagnosis. This publication was prepared according to the criteria of the AWMF on the basis of the international English‐language S3 guideline with special consideration of health system conditions in German‐speaking countries. Chronic urticaria has a high impact on the quality of life and daily activities of patients. Therefore, if causal factors cannot be eliminated, effective symptomatic treatment is necessary. The recommended first‐line treatment is to administer new generation, non‐sedating H1 antihistamines. If the standard dose is not sufficiently effective, the dose should be increased up to fourfold. For patients who do not respond to this treatment, the second‐line treatment in addition to antihistamines in the treatment algorithm is omalizumab and, if this treatment fails, ciclosporin. Other low‐evidence therapeutic agents should only be used if all treatments in the treatment algorithm agreed upon by the guideline group fail. Both the benefit‐risk profile and cost should be considered. Corticosteroids are not recommended for long‐term treatment due to their inevitable severe side effects.
Ndst1, a heparan sulfate modification enzyme, regulates neuroectodermal patterning by enhancing Wnt signaling in Xenopus
Authors: Yamamoto Takayoshi , Kambayashi Yuta , Tsukano Kohei , Michiue Tatsuo 
Published: February 2023

AbstractNeural tissue is derived from three precursor regions: neural plate, neural crest, and preplacodal ectoderm. These regions are determined by morphogen‐mediated signaling. Morphogen distribution is generally regulated by binding to an extracellular matrix component, heparan sulfate (HS) proteoglycan. HS is modified by many enzymes, such as N‐deacetyl sulfotransferase 1 (Ndst1), which is highly expressed in early development. However, functions of HS modifications in ectodermal patterning are largely unknown. In this study, we analyzed the role of Ndst1 using Xenopus embryos. We found that ndst1 was expressed in anterior neural plate and the trigeminal region at the neurula stage. ndst1 overexpression expanded the neural crest (NC) region, whereas translational inhibition reduced not only the trigeminal region, but also the adjacent NC region, especially the anterior part. At a later stage, ndst1 knocked‐down embryos showed defects in cranial ganglion formation. We also found that Ndst1 activates Wnt signaling pathway at the neurula stage. Taken together, our results suggest that N‐sulfonated HS accumulates Wnt ligand and activates Wnt signaling in ndst1‐expressing cells, but that it inhibits signaling in non‐ndst1‐expressing cells, leading to proper neuroectodermal patterning.
Luspatercept in combination with recombinant erythropoietin in patients with myelodysplastic syndrome with ring sideroblasts: Stimulating early and late‐stage erythropoiesis
Authors: Fattizzo Bruno , Versino Francesco , Bortolotti Marta , Rizzo Lorenzo , Riva Marta , Barcellini Wilma 
Published: February 2023

AbstractPatients with myelodysplastic syndromes and ring sideroblasts (MDS RS) are clinically characterized by severe anemia and transfusion need. Erythropoiesis‐stimulating agents (ESAs), which stimulate hemoglobin production and early maturation of erythroid precursors, are effective only in a portion of patients and for limited time. Luspatercept, an inhibitor of the TGF‐beta pathway, is beneficial in unblocking late‐stage erythropoiesis and has been approved for MDS RS patients failing or not‐candidate to ESAs. ESAs and/or luspatercept failure represents an unmet clinical need and most patients become life‐long transfusion dependent. Here, we describe the clinical combination of luspatercept with ESAs (subcutaneous epoetin alpha 40–80 000 IU/week) in seven MDS RS patients. Two patients had ESAs as pre‐existing therapy, while five were re‐challenged with ESAs as add‐on treatment due to luspatercept failure. Three patients achieved hematologic improvement, and one became transfusion independent. No adverse events were noted. This is the first clinical evidence that stimulating both early and late‐stage erythropoiesis may offer a further option for this challenging patient population.
The etiology and mortality of new‐onset refractory status epilepticus (NORSE) in adults: A systematic review and meta‐analysis
Authors: Tharmaraja Thahesh , Ho Jamie Sin Ying , Neligan Aidan , Rajakulendran Sanjeev 
Published: February 2023

AbstractNew‐onset refractory status epilepticus (NORSE) is a devastating neurological presentation. There is a paucity of large studies on NORSE as it is a relatively new clinical syndrome. The aim of this review was to summarize the etiologies and establish a mortality rate for NORSE. Two independent authors systematically searched the following electronic databases from January 1, 2005 April 20, 2021: PubMed, Embase, OVID, Scopus, Web of Science, “Clinicaltrials.gov,” and the International Standard Randomised Controlled Trial Number (ISRCTN) registry. We included all primary research studies of NORSE in adults and excluded commentaries, reviews, pre‐clinical studies, and pediatric populations. Etiology was extracted from all studies meeting eligibility criteria, whereas data relating to treatments, hospital stay, functional outcomes, and mortality were extracted from studies with sample size ≥5. We conducted a random‐effects meta‐analysis of mortality rate with meta‐regression testing for significant covariates. Of 1482 studies, 109 case reports and case series met our criteria, comprising 395 cases of NORSE. The most common etiology was cryptogenic in 197 cases (49.9%), followed by autoimmune in 143 cases (36.2%). The pooled mortality rate was 22% (95% confidence interval 17%–27%; = 15), with low heterogeneity ( = 0%). Meta‐regression revealed that year of study, treatment with ketogenic diet or immunotherapy, percentage of cryptogenic cases, and length of intensive care unit stay were not significant covariates for mortality. Common treatments included antiseizure medications (median 5), general anesthesia, and immunotherapy such as corticosteroids, intravenous immunoglobulin, and plasma exchange. Mean length of intensive care admission was 33.4 days, with 52% of cases diagnosed with epilepsy on discharge. Neurocognitive impairment was a common sequela of NORSE. NORSE is associated with a high mortality. Half of cases remain cryptogenic, which presents a diagnostic challenge. Future focus should be on elucidating the underlying neurobiology and determining the most effective therapeutic interventions.
Impact of regulatory restrictions on the use of valproic acid in women of childbearing age: An Italian study
Authors: Di Vito Lidia , Mazzoni Stefania , Belotti Laura Maria Beatrice , Poluzzi Elisabetta , Baldin Elisa , Zenesini Corrado , Bisulli Francesca , Tinuper Paolo , Mostacci Barbara 
Published: February 2023

AbstractObjectiveDue to significant risks to the offspring after intrauterine exposure, the European Medicines Agency issued recommendations in 2014 and 2018 restricting the use of valproate (VPA) in women of childbearing age (WOCA). We aimed to evaluate their impact in the Emilia‐Romagna region (ERR) of Northern Italy.MethodsUsing administrative databases, we identified all the ERR residents who received antiseizure medication (ASM) prescriptions from 2010 to 2020. Time series of incidence rates by sex and age group were evaluated for all ASMs. Focusing on VPA, an interrupted time series analysis was applied to assess the impact of the restrictions in WOCA with epilepsy (WOCA‐E) and WOCA with psychiatric disorders (WOCA‐P). We then evaluated the chronological order of ASM prescriptions with regard to the position of VPA.ResultsIncidence rates of VPA prescriptions overall decreased over time. A significant decrease was observed only for females. The effect was stronger for WOCA, after both the first (incidence rate ratio [IRR] = .85, 95% confidence interval [CI] = .75–.96) and the second restriction (IRR = .67, 95% CI = .55–.82). The decrease was significant after the second restriction both for WOCA‐E (IRR = .43, 95% CI = .27–.68) and for WOCA‐P (IRR = .49, 95% CI = .35–.70), as well as VPA as a first prescription in both populations. VPA prescriptions as further choice did not show the same trend.SignificanceAfter the regulatory restrictions, an overall significant decline in the use of VPA in WOCA was observed in ERR. The second restriction has been effective in consolidating the prescription trend. However, VPA appears still to be a commonly used drug in WOCA when other ASMs have failed.
Unveil the veil of limited liability: Evidence from firm investment
Authors: Qin Jiaqi , Sun Yan 
Published: February 2023

AbstractWe investigate the effect of limited liability on firm investment. We find firms that intend to borrow but have higher risk have a greater probability of changing to limited liability. With propensity score matching, difference‐in‐differences analysis, and switching regressions with an endogenous switching model, we find that, after the liability regime change, firm investment aggressiveness decreases but on a lesser level than the over‐time change for firms using unlimited liability. We also find there is improvement in investment efficiency and return on invested capital. These results suggest that limited liability encourages firm investment and leads to more effective investment policies.
White Anglo patriarchal possession in organizations: Unequal vertical career progressions among Anglo White & non‐Anglo White highly skilled immigrant women
Authors: Carangio Vassilissa 
Published: February 2023

AbstractWithin the discussion of highly skilled immigrant women workers in organizations, dominant discourses continue to pay little attention to the gender/racial dimension in relation to career progression. Although research of skilled immigrant women has revealed important insights into how the intersection of gender, race, and class shape women's work experience, the White Anglo colonial male promotion practices inscribed on Australian organizations in relation to skilled immigration remain little researched in Australia. This article explores the differences between the career progressions of cisgender, highly skilled immigrant women of different racial and ethnic backgrounds employed in a variety of industries. It reveals how both Anglo White and non‐Anglo White highly skilled immigrant women were affected by colonial patriarchal power relations, which served to hinder their career progression. However, the Whiteness of the top levels of the Australian capitalist colonial labor market benefitted the White Anglo group's vertical career growth.
MIMT1 and LINC01550 are uncharted lncRNAs down‐regulated in colorectal cancer
Authors: Vejdandoust Faramarz , Moosavi Rahmaneh , Fattahi Dolatabadi Nasrin , Zamani Atefeh , Tabatabaeian Hossein 
Published: February 2023

AbstractIncomplete knowledge of the molecular basis of colorectal cancer, with subsequent limitations in early diagnosis and effective treatment, has contributed to this form of malignancy becoming the second most common cause of cancer‐related death worldwide. With the advances in high‐throughput profiling techniques and the availability of public data sets such as The Cancer Genome Atlas Program (TCGA), a broad range of coding transcripts have been profiled and their underlying modes of action have been mapped. However, there is still a huge gap in our understanding of noncoding RNA dysregulation. To this end, we used a bioinformatics approach to shortlist and evaluate yet‐to be‐profiled long noncoding RNAs (lncRNAs) in colorectal cancer. We analysed the TCGA RNA‐seq data and followed this by validating the expression patterns using a qPCR technique. Analysing in‐house clinical samples, the real‐time PCR method revealed that the shortlisted lncRNAs, that is MER1 Repeat Containing Imprinted Transcript 1 (MIMT1) and Non‐Protein Coding RNA 1550 (LINC01550), were down‐regulated in colorectal cancer tumours compared with the paired adjacent normal tissues. Mechanistically, the in silico results suggest that LINC01550 could form a complex competitive endogenous RNA (ceRNA) network leading to the subsequent regulation of colorectal cancer‐related genes, such as CUGBP Elav‐Like Family Member (CELF2), Polypyrimidine Tract Binding Protein 1 (PTBP1) and ELAV Like RNA Binding Protein 1 (ELAV1). The findings of this work indicate that MIMT1 and LINC01550 could be novel tumour suppressor genes that can be studied further to assess their roles in regulating the cancer signalling pathway(s).
Optimality in an OLG model with nonsmooth preferences
Authors: Ohtaki Eisei 
Published: February 2023

AbstractIt is a well‐known observation that, in the overlapping generations (OLG) model with the complete market, we can judge optimality of an equilibrium allocation by examining the associated equilibrium price. Motivated by recent development in decision theory under ambiguity, this study reexamines the above observation in a stochastic OLG model with convex but not necessarily smooth preferences. It is shown that optimality of an equilibrium allocation depends on the set of possible supporting prices, not necessarily on the associated equilibrium price itself. Therefore, observations of an equilibrium price do not necessarily tell us precise information on optimality of the equilibrium allocation.
Integrating familial care and extra‐familial care into a new long‐term care policy for China: Examples from Germany's long‐term care insurance
Authors: Eggers Thurid , Xu Jia 
Published: February 2023

AbstractRapid demographic ageing constitutes a significant challenge for the Chinese social system. As China has only recently begun developing a long‐term care (LTC) policy, care provision is currently based on family care. However, the prevalence of such care is declining due to low social recognition and conflicts between family members' care and work responsibilities. Thus, a comprehensive LTC policy should expand extra‐familial care services and make family care attractive. Germany's LTC insurance is an example of a policy that integrates extra‐familial and family care. This study analyses whether China's LTC policy can gain insights from Germany's LTC policy in view of the findings from Chinese LTC pilot projects. We argue that a policy that supports extra‐familial and family care would facilitate the LTC provision preferred by older people, while also supporting relatives who wish to provide care according to their values of intergenerational solidarity.
Mechanisms underlying pathological scarring by fibroblasts during wound healing
Authors: Ma Yizhao , Liu Zhifang , Miao LinLin , Jiang Xinyu , Ruan Hongyu , Xuan Rongrong , Xu Suling 
Published: February 2023

AbstractPathological scarring is an abnormal outcome of wound healing, which often manifests as excessive proliferation and transdifferentiation of fibroblasts (FBs), and excessive deposition of the extracellular matrix. FBs are the most important effector cells involved in wound healing and scar formation. The factors that promote pathological scar formation often act on the proliferation and function of FB. In this study, we describe the factors that lead to abnormal FB formation in pathological scarring in terms of the microenvironment, signalling pathways, epigenetics, and autophagy. These findings suggest that understanding the causes of abnormal FB formation may aid in the development of precise and effective preventive and treatment strategies for pathological scarring that are associated with improved quality of life of patients.
Effects of Fe doping on structure, negative thermal expansion, and magnetic properties of antiperovskite Mn3GaN compounds
Authors: Lu Huiqing , Sun Ying , Shi Kewen , Wu Lili , Niu Ben , Wang Cong 
Published: February 2023

AbstractWe synthesized antiperovskite Mn3Ga1−xFexN (0 ≤ x ≤ 0.30) compounds and investigated their negative thermal expansion (NTE) behavior, structure, and magnetic properties. A high‐resolution transmission electron microscopy analysis and a selected‐area electron diffraction (SAED) pattern indicate that the samples have high crystallinity with a single‐phase cubic structure. Tunable NTE behavior appears below room temperature, and the NTE operation temperature range (△T) is broadened while increasing the Fe doping. Furthermore, introducing Fe in Mn3Ga1−xFexN can efficiently adjust the NTE coefficient from −232.57 × 10−6/K (x = 0) to −12.57 × 10−6/K (x = 0.20), and the corresponding △T can be broadened from △T = 22 K to 51 K. Besides, the total entropy change (ΔStotal) at the phase transitions continuously decreases from 9.2 to 4.7 J/(kg K) while increasing the Fe content from x = 0.05 to 0.10. With increasing Fe into Ga sites, the magnetic ordering varies from antiferromagnetic (AFM) to ferromagnetic (FM), the AFM to paramagnetic (PM) phase transition temperature decreases, whereas the FM to PM transition temperature increases when increasing the Fe content. The present study indicates that magnetic element doping can efficiently tune the NTE and the correlated physical features of the antiperovskite compounds.
Low sintering shrinkage porous mullite ceramics with high strength and low thermal conductivity via foam‐gelcasting
Authors: Lin Lang , Wang Hengchang , Xia Chenhe , Xu Jie , Meng Xuanyu , Yang Runwu , Hu Guoxin , Qu Yanan , Gao Feng 
Published: February 2023

AbstractExcessive sintering shrinkage leads to severe deformation and cracking, affecting the microstructure and properties of porous ceramics. Therefore, reducing sintering shrinkage and achieving near‐net‐size forming is one of the effective ways to prepare high‐performance porous ceramics. Herein, low‐shrinkage porous mullite ceramics were prepared by foam‐gelcasting using kyanite as raw material and aluminum fluoride (AlF3) as additive, through volume expansion from phase transition and gas generated from the reaction. The effects of AlF3 content on the shrinkage, porosity, compressive strength, and thermal conductivity of mullite‐based porous ceramics were investigated. The results showed that with the increase of content, the sintering shrinkage decreased, the porosity increased, and mullite whiskers were produced. Porous mullite ceramics with 30 wt% AlF3 content exhibited a whisker structure with the lowest shrinkage of 3.5%, porosity of 85.2%, compressive strength of 3.06 ± 0.51 MPa, and thermal conductivity of 0.23 W/(m·K) at room temperature. The temperature difference between the front and back sides of the sample reached 710°C under high temperature fire resistance test. The low sintering shrinkage preparation process effectively reduces the subsequent processing cost, which is significant for the preparation of high‐performance porous ceramics.
Highly transparent yttria ceramics with Nb2O5/Ta2O5 as novel sintering additives by pressureless vacuum sintering
Authors: Liu Yan , Gan Lin , Qin Xianpeng , Zhou Guohong , Jiang Juan , Zhang Tianjin , Hu Song , Wang Zhengjuan 
Published: February 2023

AbstractHighly transparent yttria ceramics were fabricated by pressureless sintering with Nb2O5 or Ta2O5 as a novel sintering additive. The optical transmittance, microstructural evolution, and thermo‐mechanical properties of the samples were investigated. The optimal doping concentrations of Nb2O5 and Ta2O5 are 0.3 and 0.2 at.%, respectively, which are much lower compared to those of previously reported counterparts. The transmittance of the sample with 0.3 at.% Nb2O5 reaches 81.6% at 1100 nm and 72.4% at 400 nm (2 mm in thickness), similar transmittance was obtained in the sample with 0.2 at.% Ta2O5. The microhardness (∼7 GPa), fracture toughness (∼0.85 MPa·m1/2), and biaxial strength (∼200 MPa) of the present samples were confirmed to be comparable or even better compared to those of previously reported transparent yttria ceramics fabricated by pressureless sintering. Furthermore, the present samples, by virtue of the low doping concentrations, possessed relatively high thermal conductivity values (>10 W/m·K), which substantially guaranteed high thermal shock resistance.