bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colon Targeted Delivery and In Vitro Evaluation of Curcumin for Colon Cancer
Authors: Pandey Amit Kumar , Sara Udaivir Singh 
Published: August 2023

Background::
The second most common cause of mortality by cancer is thought to be colorectal cancer, which is one of the most prevalent tumours in the world. Many health advantages have been linked to curcumin, which is the key component of turmeric. The goal of the current study was to create a colon-targeted microbead method coated with Eudragit S100 to improve cur-cumin targeting in the colon by speeding up the rate of its dissolution

Methods:
The ionotropic gelation process was used to create the formulations. The surface phe-nomena, bead shape, entrapment effectiveness, drug loading, and in vitro drug release were all as-sessed for formulations. Moreover, calcium alginate beads with an improved core were enteric coat-ed with Eudragit S100. The polymer concentration and curing duration significantly affected parti-cle size and entrapment effectiveness, respectively.

Results:
The particle size of the improved formulation was 705 μm, drug entrapment efficiency was 83.56%, drug loading was 28.64%, and in vitro release was 81.66% after 6 hours in phosphate buff-er at pH 6.8. After 10 hours, enteric coating with Eudragit S100 of optimized calcium alginate mi-crobeads revealed a 64.09 ± 0.16% drug release. The calculated values of the regression coefficients for the Higuchi, first-order, and zero-order models were 0.9494, 0.8913, and 0.9579, respectively. The 50% inhibitory concentration value was 2.676 based on the percentage of cell viability.

Conclusion:
To effectively treat colorectal cancer, the enteric-coated calcium alginate microbeads can deliver curcumin selectively to the colon when taken orally.
Twitter Sentiment About the US Federal Tobacco 21 Law: Mixed Methods Analysis
Authors: Dobbs Page D , Boykin Allison Ames , Ezike Nnamdi , Myers Aaron J , Colditz Jason B , Primack Brian A 
Published: August 2023

Background
On December 20, 2019, the US “Tobacco 21” law raised the minimum legal sales age of tobacco products to 21 years. Initial research suggests that misinformation about Tobacco 21 circulated via news sources on Twitter and that sentiment about the law was associated with particular types of tobacco products and included discussions about other age-related behaviors. However, underlying themes about this sentiment as well as temporal trends leading up to enactment of the law have not been explored.

Objective
This study sought to examine (1) sentiment (pro-, anti-, and neutral policy) about Tobacco 21 on Twitter and (2) volume patterns (number of tweets) of Twitter discussions leading up to the enactment of the federal law.

Methods
We collected tweets related to Tobacco 21 posted between September 4, 2019, and December 31, 2019. A 2% subsample of tweets (4628/231,447) was annotated by 2 experienced, trained coders for policy-related information and sentiment. To do this, a codebook was developed using an inductive procedure that outlined the operational definitions and examples for the human coders to annotate sentiment (pro-, anti-, and neutral policy). Following the annotation of the data, the researchers used a thematic analysis to determine emergent themes per sentiment category. The data were then annotated again to capture frequencies of emergent themes. Concurrently, we examined trends in the volume of Tobacco 21–related tweets (weekly rhythms and total number of tweets over the time data were collected) and analyzed the qualitative discussions occurring at those peak times.

Results
The most prevalent category of tweets related to Tobacco 21 was neutral policy (514/1113, 46.2%), followed by antipolicy (432/1113, 38.8%); 167 of 1113 (15%) were propolicy or supportive of the law. Key themes identified among neutral tweets were news reports and discussion of political figures, parties, or government involvement in general. Most discussions were generated from news sources and surfaced in the final days before enactment. Tweets opposing Tobacco 21 mentioned that the law was unfair to young audiences who were addicted to nicotine and were skeptical of the law’s efficacy and importance. Methods used to evade the law were found to be represented in both neutral and antipolicy tweets. Propolicy tweets focused on the protection of youth and described the law as a sensible regulatory approach rather than a complete ban of all products or flavored products. Four spikes in daily volume were noted, 2 of which corresponded with political speeches and 2 with the preparation and passage of the legislation.

Conclusions
Understanding themes of public sentiment—as well as when Twitter activity is most active—will help public health professionals to optimize health promotion activities to increase community readiness and respond to enforcement needs including education for retailers and the general public.
ANALISIS PENDAPATAN USAHATANI RUMPUT LAUT DI DESA BAHONSUAI KECAMATAN BUMI RAYA KABUPATEN MOROWALI
Authors: Anjas Anjas , Pratama Moh Fardhal 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui berapa besar pendapatan petani rumput laut.Data yang digunakan dalam penelitian ini adalah data kuantitatif dan kualitatif.Teknik pengumpulan data yang digunakan dengan metode observasi, kuisioner dan wawancara. Penentuan sampel dilakukan dengan metode sensus, dengan mengambil semua petani rumput laut yang masih aktif. Dalam hal ini jumlah responden yang masih aktif berjumlah 30 orang.Penelitian ini menggunakan data primer dan sekunder. Analisis data yang digunakan dalam penelitian ini adalah analisis pendapatan.Hasil analisis pendapatan yang diperoleh menunjukkan bahwa rata-rata pendapatan yang diperoleh petani rumput laut satu kali musim tanam sebesar Rp. 11.192.867/1,1ha atau dikonversikan sebesar Rp.10.175.334/ha.Oleh karena itu, keberlanjutan usaha perlu dikembangkan dalam hal meningkatkan kualitas produksi sehingga harga jual produk lebih tinggi yang pada akhirnya dapat meningkatkan pendapatan masyarakatnya.
Gut Microbiota and its impact on the inflammation-dysplasia-cancer sequence
Authors: Lazarchuk Ivanna , Parmar Shivika , Wozniak Slawomir 
Published: August 2023

Abstract
The understanding and explanation of inflammation-dysplasia-cancer sequence is challenging. The gut microbiota is an important factor for the intestine wall. The changes in bacteria quality and/or quantity (dysbiosis) may begin the colon inflammation. This paper reviewed the gut microbiome risk factors which may lead to colon cancer.
New Pexiderizations of Drygas’ Functional Equation on Abelian Semigroups
Authors: Aissi Youssef , Zeglami Driss 
Published: August 2023

Abstract
Let (S, +) be an abelian semigroup, let (H, +) be an abelian group which is uniquely 2-divisible, and let ϕ be an endomorphism of S. We find the solutions f, h : S → H of each of the functional equations

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\matrix{ {f\left( {x + y} \right) + f\left( {x + \varphi \left( y \right)} \right) = h\left( x \right) + f\left( y \right) + f \circ \varphi \left( y \right),\,x,y \in S,} \hfill \cr {f\left( {x + y} \right) + f\left( {x + \varphi \left( y \right)} \right) = h\left( x \right) + 2f\left( y \right),\,x,y \in S,} \hfill \cr }

in terms of additive and bi-additive maps. Moreover, as applications, we determine the solutions of some related functional equations.
Men Think they Know More about Networks
Authors: Neal Zachary P. 
Published: August 2023

Abstract
The fields of social network analysis and network science have recently undertaken efforts to address issues of gender diversity and representation. However, despite these important efforts, subtle threats to representation are likely to persist. I use a 2023 global survey of 260 network researchers to show that men rate themselves as having more expertise with networks than women. This is troubling because, to the extent that women believe they lack the expertise to be considered for awards or collaboration opportunities, it can impede other efforts to diversify the field. I conclude by discussing some possible explanations for this finding and some possible strategies for addressing its consequences.
Evaluation of phenotypic variability of seedlings obtained from open pollination of three varieties of the genus Hylotelephium
Authors: Sotolářová Oldřiška , Sotolář Radek , Vachůn Miroslav , Pokluda Robert , Uher Jiří 
Published: August 2023

ABSTRACT
This article reflects on the conventional open pollination breeding method of the genus Hylotelephium. Six-year-old seedlings were evaluated and compared with the mother plants for 3 years. A total of 1 063 seedlings were evaluated (54 in the H. ‘Red Cauli’, 90 descendants in the H. ‘Xenox’, 919 descendants in the H. ‘Purple Emperor’). This study deals with six evaluated characters of vegetative parts of plants (habit, height and width of plants, length and width of leaves and the colour of the upper side of the leaves). The most significant phenotypic variability was confirmed for habit, plant height, leaf colour in summer and leaf length in population H. ‘Xenox’ and for spring colouration of lower leaves in population H. ‘Red Cauli’. The highest degree of variability was found for plant height, where the monitored populations split into a total of seven different sizes. On the contrary, the lowest degree of variability was demonstrated for the length and width of leaves, where all populations showed shorter and narrower leaves compared to the mother plants, with minimal differences.
Modified gate activation functions of Bi-LSTM-based SC-FDMA channel equalization
Authors: Mohamed Mohamed A. , Hassan Hassan A. , Essai Mohamed H. , Esmaiel Hamada , Mubarak Ahmed S. , Omer Osama A. 
Published: August 2023

AbstractIn recent years, artificial neural networks (ANNs) have grown a lot and helped solve numerous problems in wireless communication systems. We have evaluated the performance of the Bidirectional-Long-Short-Term-Memory (Bi-LSTM) recurrent neural networks (RNNs) for joint blind channel equalization and symbol detection using a variety of activation functions (Afs) for the gate units (sigmoid) of Bi-LSTMs without requiring any prior knowledge of channel state information (CSI). The performance of Bi-LSTM networks with different AFs found in the literature is compared. This comparison was carried out with the assistance of three different learning algorithms, namely Adam, rmsprop, and SGdm. The research findings clearly show that performance, as measured by equalization accuracy, can be improved. Furthermore, demonstrate that the sigmoid gate activation function (GAF), which is commonly used in Bi-LSTMs, does not significantly contribute to optimal network behavior. In contrast, there are a great many less well-known AFs that are capable of outperforming the ones that are most frequently utilized.
The Power of Language in the Romanian Political Discourse
Authors: Corlăteanu Aniela Ioana 
Published: August 2023

Abstract
The impact of communication upon political activities is inevitable, regardless whether we refer to socialization, participation, the establishment of an agenda, mobilization or negotiation. Every political activity is influenced by communication inasmuch as almost all such manifestations involve the use of a form of communication. The assertion of a moral and professional authority’s competence and credibility is increasingly rivaled by media credibility or by the charisma, whose importance is admitted by journalists and image counselors. Thus, it is by means of their aggressive discourse that most of the Romanian political leaders have built up this ‘charisma’. In a period of crisis and shortcomings, who could wish to see faded characters, deprived of personality, on television? In Romania, not revolting against ‘someone’ and not opposing them are equivalent to being unaware of the people’s sufferance and, therefore, one cannot be a good leader.
Brewing Indigenisation, Filtering Westernisation: A Socio-Historical Study of Locally Brewed Alcoholic Drinks in Bhutan
Authors: Dey Sayan 
Published: August 2023

Abstract
Amongst the various indigenous societies across the planet, alcohol has always played a pivotal role in shaping and preserving different forms of social, cultural, communal, personal, and familial values in an inter-generational and transcultural manner. With the advent of European colonisation, over different segments of time and space across the globe, this community practice was disrupted and dismantled as unmodern, unhygienic, non-civilising, and dehumanising. However, such community practices in Bhutan remained unaffected till the beginning of the 21st century. In 2007, with the establishment of a democratic governing system, as Bhutan started welcoming foreign investors, the West (Europe and USA) invaded the local markets of Bhutan. Gradually, the individuals were attracted towards the western-branded alcoholic drinks and the consumption of the locally brewed alcoholic drinks started declining. Keeping these arguments at the forefront, this article makes an effort to socio-historically analyse the various ways through which the culture of brewing, consuming, and sharing the locally brewed alcoholic drinks functions as a tool to resist the westernisation of the culture of drinking in contemporary Bhutan.
Strategic Observatory for Europe 2030: Jean Monnet Centre of Excellence SOE2030 and Its Impact
Authors: Rončević Borut 
Published: August 2023

AbstractThe main goal of Agenda 2030, the third and current strategic document of the European Union (EU), is to steer its development in pursuit of its Sustainable Development Goals. However, both policy research and policy practice have revealed a relatively poor implementation record of the EU grand strategy. The implementation of Agenda 2030 may be even more challenging, since it is not only an official EU grand strategy, but, more pervasively, a document accepted by the United Nations and whose implementation has global ambitions and also encounters many obstacles deriving their origin from beyond the borders of the EU. This promises that implementation and factors contributing to successes and failures of the EU grand strategies will remain an interesting research topic. In this article we present the possible application of Cultural Political Economy (CPE) approach in this research and present its application in the framework of Jean Monnet Centre of Excellence titled Strategic Observatory for Europe 2030 (SOE2030).
Die „unmenschliche“ Revolution – Künstliche Intelligenz als Schicksalstechnologie für Deutschland und Europa
Authors: Vöpel Henning 
Published: August 2023

Abstract
Artificial intelligence defines a new age of technological and economic progress, but also causes disruptive effects on business models, industries, and the society in general. It is argued that in order to make AI a productive and progressive technology regulatory as well as educational requirements must first be matched. Threats and opportunities must be weighed up in advance. Given the coincidence of geo-political shift and industrial transformation, becoming a leading and competitive player in the game of AI is key for the German and European economy. In order to do so, AI must be developed both in a responsible as well as innovative way. Otherwise, Germany and Europe would lose ground against China and the US at the beginning of a new age of progress.
Die schwierige Lage auf dem deutschen Ausbildungsmarkt
Authors: Schuß Eric 
Published: August 2023

Abstract
Firms face increasing problems of filling training places in the past years. To counteract this development, different measures are discussed by policymakers and the scientific community. The planned training guarantee is mainly directed at persons with no school graduation certificate or with main school graduation. To increase the attractiveness of dual apprenticeship training for persons with university (of applied science) entrance qualification, it is also discussed by policymakers to extend vocational orientation. In this context, this study considers the current situation of the German apprenticeship market. In doing so, it focuses on the career aspirations of young people and that these often do not meet the demand of the German economy.
PERBANDINGAN HASIL ANTARA METODE PEMERIKSAAN ELISA DAN RAPID TEST UNTUK SKRINING HIV/AIDS
Authors: Sintya Dewi Tjokorda Istri Agung , Wande I Nyoman , Gde Oka Tjokorda 
Published: August 2023

Acquired Immunodeficiency Syndrome (AIDS) adalah kumpulan gejala atau penyakit yang diakibatkan menurunnya kekebalan tubuh akibat infeksi oleh virus Human Immunodeficiency Virus (HIV). Gold Standar pada pemeriksaan skrining yang digunakan adalah Enzyme Linked Immunosorbent Assay (ELISA). Pemeriksaan ELISA membutuhkan waktu lebih lama, maka dari itu terjadi pergeseran penggunaan ELISA ke Rapid Test.Tujuan dari penelitian ini adalah untuk mengetahui ada atau tidaknya perbedaan hasil dalam metode pemeriksaan ELISA dan metode pemeriksaan Rapid Test untuk skrining HIV/AIDS. Penelitian ini telah dilakukan di UDD PMI Kodya Denpasar/RSUD Wangaya pada bulan Maret sampai dengan Agustus 2016. Penelitian ini menggunakan desain penelitian analitik dengan menggunakan pendekatan longitudinal terhadap 80 sampel donor. Hasil uji ELISA dan Rapis Test ditampilkan dalam bentuk tabel 2x2 dan diuji dengan uji diagnostik. Hasil dari uji diagnostik dilihat dari sensitivitasnya Rapid Test dapat mengklarifikasi sampel donor dengan HIV/AIDS benar-benar sakit pada kenyataannya adalah 100%. Jika dilihat dari spesifisitasnya Rapid Test dapat mengkonfirmasi sampel donor yang benar-benar bebas dari HIV/AIDS sesuai kenyataannya sebesar 100%. Sama halnya dengan Rapid Test, ELISA dapat mengklarifikasi sampel donor dengan HIV/AIDS benar-benar sakit pada kenyataannya adalah 100%. Jika dilihat dari spesifisitasnya ELISA dapat mengkonfirmasi sampel donor yang benar-benar bebas dari HIV/AIDS sesuai dengan kenyataannya sebesar 100%.Dapat disimpulkan tidak ada perbedaan hasil skrining HIV/AIDS dan tidak terdapat perbedaan antara metode pemeriksaan ELISA dan Rapid Test untuk skrining HIV/AIDS dilihat dari sensitivitas dan spesifisitas yang sama.
Kata Kunci: HIV/AIDS, ELISA, Rapid Test
CORRELATION BETWEEN RESULT OF ABDOMEN MDCT SCAN AND ERCP IN OBSTRUCTION ICTERIC PATIENT
Authors: Asnur Ariany , Murtala Bachtiar , Latief Nikmatia , Seweng Arifin , Daud Nu’man As , Idris Nurlaily 
Published: August 2023

This study aims to find out correlation between result of abdominal MDCT scan abdomen and ERCP in obstruction icteric patient.
This study was a cross sectional and retrospective study including all patient with intrahepatic or extrahepatic or both cholestatic in abdominal MDCT scan without and with contrass enhance and ERCP in Dr. Wahidin Sudirohusodo hospital, over period of two years and four months from January 2018 to Apriil 2020. Minimal 31 data were collected, using Kappa and p value <0,05.
Among the 174 samples, 81 samples (46,6%) undergo abdominal MDCT scan without contrass enhance and 93% samples (53,4%) undergo abdominal MDCT scan with contrass enhance. Majority belong to 41-50 and 51-60 year age groups is 60 samples (34,5%) and 44 samples (25,35%). Males are more than females in number that is 57,5% dan 42,5%. there is correlation among result in abdominal MDCT scan without and with contrass enhance and ERCP in the cholestatic, location and cause of obstruction biliary. Majority cholestatic in intra and extrahepatic duct, the obstruction location in extrahepatic duct and the cause of obstruction is benign for MDCT scan without contrass enhance and malignant in MDCT scan with contrass enhance. There is significat correlation among cholestatic, location and cause of obstruction in abdominal MDCT scan without and with contrass enhance and ERCP.
PERAN KEPERCAYAAN MEMEDIASI PENGARUH CITRA MEREK TERHADAP NIAT BELI DI TOKOPEDIA
Authors: Wiratama I Komang , Warmika I Gde Ketut , Giantari I Gst. Ayu Kt. 
Published: August 2023

Indonesia is a country with high internet users. The high number of internet users provides opportunities for online businesses in Indonesia to develop, one of which is the Tokopedia marketplace. This study aims to analyse the role of trust in mediating the effect of brand image on purchase intention. This research was conducted at the Tokopedia marketplace in Denpasar City with a sample size of 110 respondents using a questionnaire using a Likert Scale. The sample was determined using a non-probability sampling model with purposive sampling technique. The data analysis technique used is path analysis with the help of the SPSS for windows program. The results of the analysis in this study indicate that brand image and trust have a positive and significant effect on purchase intention, brand image has a positive and significant effect on trust, and trust partially mediates the relationship between brand image and purchase intention. The implications of this study can be a reference for the Tokopedia company to be able to develop strategies in an effort to maintain and improve brand image and consumer confidence, so as to increase consumer interest in transacting through Tokopedia.
Keywords: Brand Image; Trust; Purchase Intention
TINGKAT KESIAPAN PENGGUNAAN E-LEARNING (E-LEARNING READINESS) PADA MAHASISWA PROGRAM STUDI SARJANA KEDOKTERAN DAN PROFESI DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA
Authors: Wijaya Lisa Amelia , Wardani Ni Putu , Laksemi Dewa Ayu Agus Sri , Diarthini Ni Luh Putu Eka 
Published: August 2023

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ABSTRAK
E-learning adalah sistem belajar mengajar yang menggunakan media elektronik dan sudah digunakan di beberapa perguruan tinggi di Indonesia, salah satunya Program Studi Sarjana Kedokteran dan Profesi Dokter Fakultas Kedokteran Universitas Udayana (PSSKPD FK Unud). Penelitian ini dilakukan dengan tujuan untuk mengetahui tingkat kesiapan pelaksanaan e-learning di PSSKPD FK Unud. Penelitian ini merupakan penelitian deskriptif dengan desain penelitian cross-sectional. Penelitian ini menggunakan kuesioner berdasarkan model e-learning readiness Aydin dan Tasci yang terdiri atas 37 pertanyaan yang dibagi ke dalam empat faktor, antara lain faktor teknologi, faktor sumber daya manusia, faktor pengembangan diri, dan faktor inovasi. Kuesioner ini ditujukan pada seluruh mahasiswa PSSKPD FK Unud angkatan 2019 dimana penelitian ini dilaksanakan di FK Unud. Berdasarkan hasil penelitian yang melibatkan 242 dari 254 mahasiswa yang terdaftar sebagai mahasiswa PSSKPD angkatan 2019 didapatkan bahwa skor kesiapan e-learning PSSKPD FK Unud sebesar x? = 3,98. Skor kesiapan ini menandakan bahwa PSSKPD FK Unud tergolong ke dalam kategori siap, tetapi membutuhkan beberapa peningkatan (3,4 < x? ? 4,2). Adapun peningkatan yang dibutuhkan, yaitu peningkatan dalam faktor teknologi (x? = 4,17), faktor sumber daya manusia (x? = 4,03), faktor pengembangan diri (x? = 3,90), dan faktor inovasi (x? = 3,81). Penilaian terhadap tingkat kesiapan penyelenggaraan e-learning ini perlu dilakukan secara berkala untuk mengevaluasi serta meningkatkan kualitas dari pelaksanaan e-learning di PSSKPD FK Unud.
Kata kunci : e-learning readiness, Aydin dan Tasci, PSSKPD FK Unud