bluuebunny/crossref_metadata_2025_split huggingface dataset:
Red Betel Leaf Bioactive Compounds as ERα Receptor Inhibitors In Silico and MCF-7 Cell Anticancer In Vitro
Authors: Nursyarah Ayu Tri , Safithri Mega , Andrianto Dimas 
Published: July 2023

Cancer is one of the leading causes of death in the world. Excess endogenous estrogen is a risk factor for breast cancer. Red betel leaf herbal plants have been used as an alternative cervical and colon cancer treatment. This study aimed to obtain the active compounds that play a role in ERα receptor inhibitors in silico and to determine the anti-breast cancer cytotoxic activity of the extract and fraction of red betel leaf against MCF-7 cells. We use in silico research method using the YASARA Structure software with anti-breast cancer receptors, namely 3ERT, and in vitro using the MTT test on the anti-breast cancer cytotoxic activity of MCF-7 cells. There are 38 compounds that were obtained from the research. The results of the in silico test showed that the bioactive compound that played a role in inhibiting the ERα was 2-(4-Hydro xyphenyl)-2-phenyl-N(3,3-diphenylpropyl)-acetamide (44578655), a compound from water fraction, with an inhibition constant of 2.82 × 10-8 µM and Gibbs free energy of –10.2880 Kcal/mol. In vitro results showed that the best cell growth inhibition value was obtained from the n-hexane fraction at a concentration of 500 ppm of 73.42%. The conclusions of this study indicate that the bioactive compound of red betel leaf is water fraction is the best fraction inhibition. However, the hexane fraction proved to have cytotoxic activity against breast cancer MCF-7 cells.
Influence of financing water protection measures in the field of transport on water quality of water bodies
Authors: Chernikov N. A. , Tvardovskaya N. V. , Okhremenko I. M. 
Published: July 2023

Transport is a major water consumer and source of environmental pollution, including water resources. In order to preserve and improve water quality in water bodies at industrial and transport enterprises, including railway enterprises, water protection measures entailing permanent signifi cant funding are required. The study is aimed to develop a methodology for determining dependence of water quality of the water body on the real financing of water protection measures; theoretical justifi cation of the choice of water quality of the water body from the quality of wastewater (WW) of water users, discharging them into the water body and amount of financing of water protection measures. The solution of the task of determining the best water quality in a water body under limited fi nancing of water protection measures and rational distribution of fi nancial resources between water users, including transport infrastructure objects, is proposed. Financing of water protection measures in Russia is less than abroad and has been decreasing over the last three decades. The limits for pollutant concentrations in pollutant discharges into water bodies and water disposal systems in Russia are often set very strict, sometimes more stringent than those for drinking water, which leads to unjustifi ed spending of investment costs. It is pointed out that at present in Russia market relations in the field of nature and, in particular, water use have not been formed. The basic diffi culties at realization of these relations in our country are designated. When using the proposed methodology, the rational quality of water resources of water users by limiting pollutants and the rational distribution of funds for water protection measures among water users within the limited amount of financing are determined. The extent to which water quality in a water body changes is also determined. The possibility of practical application of the proposed methodology is considered.
The Functional Strategy of PT. Kereta Api Indonesia (Persero) at UPT (Technical Implementation Unit) Jatinegara Locomotive Depot
Authors: Burhan Karunia 
Published: July 2023

Developments and changes in the business climate in industry era 4.0 now requires companies to be more careful in making to a decision that is comprehensive which later will underlie keput usan that is strategy . By formulating a strategy means the company has made a formulation of what must be done both at the corporate level (company), business and functional. In this study will be discussed about how the functional level strategy carried out by PT. Kereta Api Indonesia (Persero) / KAI at UPT (Technical Implementation Unit) Jatinegara Locomotive Dipo . UPT (Technical Implementation Unit) Jatinegara locomotive depot, a workshop for its fleet of locomotives busiest in Pul au serve the needs of Java in a series of long distance train relation 1 Jakarta area of operations throughout the regions of oper ation in Java. As a UPT which is very influential on the smooth supply of railroad services , an effective and efficient strategy is certainly needed . In the study, it will simulate the kaizen method in the UPT (Technical Implementation Unit) of the Jatinegara Locomotive Dipo in carrying out its functional strategy by making direct observations and comparing qualitative data from interviews .
Mechanical Performance of Acetate Lacquer from Acacia mangium
Authors: Gilbert Jesuet Melissa Sharmah , Palle Ismawati , Liew Kang Chiang 
Published: July 2023

Cellulose comprise of about 40–50 % of the composition of wood, making it one of the most abundant organic polymers on earth. Cellulose is very versatile in terms of application, with a wide array of products fabricated, including the chemically modified cellulose derivatives. One of the more prominent and multifaceted derivatives is the cellulose acetate, in which have been used predominantly as cigarette filters, membrane filters, and coating. In this study, the intermediate product, Acacia mangium-produced cellulose acetate was modified into lacquer to produce a feasible wood coating product. The lacquer underwent a series of tests such as impact, abrasion, adhesion, and hardness to evaluate its mechanical performance. The results of the coating were compared to a similarly formulated acetate lacquer that was produced using commercial cellulose acetate instead as a control. Based on the result, it is shown that Acacia mangium-produced cellulose acetate lacquer shows a better impact resistance with a rating of 4 as opposed to the commercial cellulose acetate with a rating of 3 with moderate cracking, with an approximate 6% better abrasion resistance and higher hardness rating class. Meanwhile, the commercial cellulose acetate lacquer presents a better adhesion performance with only 5% flaking compared to the 15% flaking of Acacia mangium-produced cellulose acetate lacquer. The Acacia mangium-produced cellulose acetate lacquer indicates a novel benefit from the presence of impurities from the intermediate Acacia mangium-produced cellulose acetate product such as the plasticizing hemicellulose acetate, as well as the hydrophobic lignin.
CONTRAST ENHANCEMENT OF FLAT EEG IMAGES VIA INTUITIONISTIC FUZZY APPROACH
Authors: Suzelawati Z. 
Published: July 2023

Image enhancement is an initial step in medical imaging before further processing. It is a process to improve the quality of an image which is affected by the presence of noise. Various approaches such as classical and fuzzy methods are used in the area of image processing to obtain the desired output. However, in this paper, an advanced fuzzy approach for contrast enhancement is used. The method is known as intuitionistic fuzzy set (IFS) and it is implemented on flat EEG (fEEG) input images during epileptic seizures. The output images are displayed with different values of parameter   lambda, . Unsmooth output images occurred as increased.
CLOTH SIMULATION USING AN ENHANCED CATMULL-CLARK SUBDIVISION SCHEME AND COLLISION DETECTION IN A VIRTUAL ENVIRONMENT
Authors: Sivaraja Tulasii , Bade Abdullah 
Published: July 2023

Subdivision surface techniques smoothen the surface of any 3D object by splitting the polygons into smaller sub-polygons. However, most methods of subdivision encounter the same problem when dealing with extraordinary points. This project aims is to implement an enhanced Catmull-Clark subdivision scheme and simulated cloth that can detect and identify the collision ofan object against the simulated cloth in a virtual environment. The original Catmull-Clark subdivision scheme was enhanced by manipulating the weights present in the original scheme while adhering to a few rules. The cloth used a mass-spring model to be initialised, and the enhanced subdivision scheme was integrated into this model. Then, the collision detection was performed based on the bounding volume approach, and an appropriate collision response was used to simulate the behaviour of the cloth in real life. Experiments and tests were conducted to evaluate the smoothness ofthe enhanced subdivision scheme and the computation time. The enhanced subdivision scheme was only able to create an acceptably smooth surface until the second iteration ofthe subdivision. On the third iteration, noticeable sharp points were present, which indicated that the enhanced subdivision scheme did not improve the original scheme. Additionally, the execution time for the enhanced subdivision schemewas insignificantly longer compared to the original scheme for all the levels ofsubdivision. The frame rate test showed that the cloth simulation ran at the average rate of43.572 fps, which was within the acceptable range. In conclusion, this research focuses on creating a cloth simulation that implemented an enhanced Catmull-Clark subdivision scheme and collision detection. However, the proposed enhancement for this scheme can be improved to account for the subdivision at individual cases of extraordinary points.
PLATE NUMBER RECOGNITION SYSTEMS BASED ON A CONTOURS AND CHARACTER RECOGNITION APPROACH
Authors: Bade Prof. Madya Dr. Abdullah , Chua Jing Yi , Lee Rechard 
Published: July 2023

License plate recognition system (LPR) plays an important role in intelligent traffic control system. However, most of the existing LPR are complex and hard to implement. The aim of this project is to improve the LPR techniques in terms of speed and accuracy by applying the Connected Component Analysis (CCA) and K-Nearest Neighbour algorithm (KNN). The LPR is divided into three stages which are image pre-processing, character segmentation, and character recognition. First, the input plate image will undergo some image property functions such as omission of noise to enhance the quality of the image. The CCA is applied to segment the characters by drawing rectangle boxes on each character, based on contours to extract the characters into smaller images. These images are then used as query images in character recognition stage. The images are fed to a pre-defined KNN classifier to determine the features of each image and to identify them. Five experiments were carried out to validate the proposed system. Ten Malaysia single row plate images and two foreign plate images were used as the input images on these tests. The findings show that the proposed system has an 80.0% success rate in segmentation, 92.21% accuracy rate in recognition, the optimal K value is 1, and the input image must be in a single row and comprises of a black background and white characters namely letters and digits. In conclusion, a prototype for plate number recognition has been developed with a high success rate in segmentation and a high accuracy in character recognition. Suggested future studies include a focus on segmenting double row license plates and recognizing similar characters.
ESTIMATING MANGROVE ABOVE-GROUND BIOMASS (AGB) IN SABAH, MALAYSIA USING FIELD MEASUREMENTS, SHUTTLE RADAR TOPOGRAPHY MISSION AND LANDSAT DATA
Authors: Phua Mui-How , Wong Charissa J. , James Daniel , A. Besar Normah 
Published: July 2023

Mangroves are one of the most productive forest ecosystems and play an important role in carbon storage. We examined the use of Shuttle Radar Topography Mission (SRTM) data to estimate mangrove Above-ground Biomass (AGB) in Sabah, Malaysia. SRTM-DEM can be considered as Canopy Height Model (CHM) because of the flat coastal topography. Nevertheless, we also introduced ground elevation correction using a Digital Terrain Model (DTM) generated with GIS and coastal profile data. We mapped the mangrove forest cover using Landsat imagery acquired in 2015 with the supervised classification method (Kappa coefficient of 0.81). Regression analyses of field AGB and the CHMs resulted in an estimation model with the corrected CHM as the best predictor (R2: 0.73) and cross-validated Root Mean Square Error (RMSE) was 19.70 Mg ha-1 (RMSE%: 11.60). Our study showed Sabah has a mangrove cover of 268,631.91 ha with a total AGB of 44,163,207.07 Mg in 2015. This substantial amount of carbon storage should be monitored over time and managed as part of the climate change mitigation strategy.
Türkiye: macro-financial situation
Authors: Sánchez Paula , Melgar Alejandro , del Río Pedro 
Published: July 2023

RationaleTürkiye is identified annually as a material country for the Spanish and euro area banking systems. Moreover, both are linked to Türkiye by major trade and financial flows. It is therefore important to monitor the country’s macro-financial situation and main weaknesses.Takeaways•The Turkish economy has continued to post very high, albeit slowing, inflation rates since late 2022, and economic activity has slowed, against a background of sizeable external financing needs, foreign currency debt and low international reserves.•Fiscal policy kept the country’s accounts healthy in 2022, although a significant downturn is expected in 2023. In terms of monetary policy, the Central Bank of the Republic of Türkiye cut the policy interest rate again in February, with the real interest rate standing at -35.2% in April.•The banking system remains healthy, although some indicators have worsened. Furthermore, to keep credit growth in check and encourage more widespread use of the lira in the financial system, the macroprudential and regulatory measures introduced in 2021 and 2022 remained in place and were strengthened.
دراسة تأثير درجات الحرارة و التكييس على تخزين ثمار التفاح صنف "روم بيوتي
Authors: جادالله سليمان عمر 
Published: July 2023

أجريت هذه الدراسة في موسمي 2000 و 2001 على ثمار التفاح صنف "روم بيوتي" النامية تحت الظروف المناخية لمنطقة الجبل الأخضر بهدف تحديد أفضل درجة حرارة لتخزين تلك الثمار وتقييم جدوى تكييس الثمار في أكياس "البولي ايثلين" عند درجة حرارة مرتفعة نسبيا (5°م) كبديل للتخزين عند درجات حرارة منخفضة (0 و 3°م) . وبتتبع التغيرات في بعض الصفات الكيميائية والطبيعية للثمار وكذلك ظهور الأمراض والأضرار الفسيولوجية خلال فترة التخزين وجد آلاتي : تفوقت ثمار الصنف "روم بيوتى" غير المكيسة والمخزنة عند درجة حرارة 0 و 3°م من حيث انخفاض نسبة الحموضة ، ارتفاع نسبة المواد الصلبة الذائبة الكلية وانخفاض نسبة الفقد في الوزن ونسبة التالف (نتيجة الأمراض والأضرار الفسيووجية ) مقارنة بالثمار غير المكيسة و المخزنة عند درجة حرارة 5°م بينما لم تتفوق ثمار التفاح المخزنة عند درجة حرارة 0°م عن الثمار المخزنة عند درجة حرارة 3°م ، إلا في الصلابة وفي انخفاض نسبة التالف (نتيجة الأمراض والعيوب الفسيولوجية) . ولم يؤدي تكييس الثمار "بالبولي ايثلين" إلى المحافظة على جودة ثمار الصنف "روم بيوتي" حيث ارتفعت نسبة التالف في جميع الثمار المكيسة في أكياس مثقبة وغير مثقبة عند درجة حرارة 5°م مقارنة بالثمار غير المكيسة عند درجات الحرارة المختلفة (0 ، 3 و 5°م) . بينما أدى تكييس الثمار إلى المحافظة على نسبة المواد الصلبة الذائبة الكلية مقارنة بالثمار غير المكيسة و المخزنة عند درجة حرارة 5°م ، كما أدى تكييس الثمار في أكياس غير مثقبة إلى خفض نسبة الفقد في الوزن مقارنة بجميع المعاملات باستثناء الثمار غير المكيسة والمخزنة عند درجة حرارة 0°م حيث تساوت معها في تلك النسبة
Nanogels obtenus par interactions électrostatiques ; Formulation, caractérisations et études de libérations.
Authors: Dieng Sidy mouhamed , Fall Ahmédou Bamba Koueimel , SY Papa Mady , Djiboune Alphone Rodrigue , Niass Mamadou , Diouf Louis Augustin Diagua , Mbaye Gora , Thioune Oumar , Diarra Mounibé 
Published: July 2023

La nanoformulation est un domaine en plein essor depuis le développement de vecteurs permettant d’encapsuler des molécules hydrosolubles, liposoluble et ou amphiphiles pour la délivrance de médicaments. Les nouveaux agents thérapeutiques étant en majeur partie lipophiles, le développement de nouvelles formulations permettant leur transport au niveau de leurs sites d’action constitue de nos jours un enjeu majeur. Les nanogels pourraient jouer ce rôle en servant de réservoir et permettre le transport et la libération des principes actifs au niveau des sites d’actions. En effet, les nanogels ont une grande faculté de pénétration, Ils augmentent la solubilité et l’index thérapeutique des PA diminuant ainsi la toxicité.
Dans notre étude nous avons élaboré des nanogels mixtes de type huile-dans-eau, de quelques dizaines de nanomètres de diamètre, stabilisées par un surfactant composée d’huile de ricin et d’agents de furtivité (PEG). Nous avons procédé à la formulation de nanogels en utilisant un polymère lipophile (poly (Maleic anhydride-alt-1-Octadecene)) PMAO qui est solubilisé dans la phase huileuse et un polymère hydrophile le chitosane solubilisé dans la phase aqueuse.
La formulation est repose sur les interactions électrostatiques avec un polymère chargé positivement dans la phase aqueuse et des groupements carboxylates à la surface des nanogouttelettes de nanogels.
La caractérisation a été effectuée par diffusion dynamique de la lumière, zétametrie et spectrophotometrie UV Visible. Sur l’ensemble des préparations retenues aucun phénomène d’instabilité n’a été observé. Concernant la taille et l’indice de polydispersité des nanogels, nous avons trouvé qu’ils dépendent du pourcentage de Chitosane. Le potentiel zêta évolue en fonction de la quantité de Chitosane. La libération du Kétoproféne est comparable à celle des hormones). En effet, nous n’avons observé que 6% de libération après 210min. Notre étude à montrer la possibilité d’élaborer des nanogels mixtes constitué de lipide et de polymère en vue du transport et de la libération de PA lipophiles.
Formulation de pilules effervescente à base d'Hibiscus sabdariffa
Authors: Diop Moussa , Sarr Serigne Omar , Fall Bamba Koumell , Badji Khady 
Published: July 2023

Hibiscus sabdariffa est une Malvacées dont les calices servent à la fabrication de boissons à propriétés nutritives et médicinale. Ces propriétés sont dû aux anthocyanes mais également à sa richesse en mucilage. Cette boisson est souvent présentée sous forme de solution ou de concentré à diluer au moment de l’emploi. Cependant ces formes aqueuses ont tendance à fermenter, limitant leur conservation. Transformer ces formes se aqueux en formes plus facilement conservables présente donc un intérêt stratégique pour la valorisation de cette boisson. En pratique courante, pour y parvenir, la poudre d’hibiscus est obtenue en faisant divers ajouts d’extrait aqueux sur du sucre, et en séchant de façon répétée jusqu’à obtention du produit sec qui est en réalité du sucre imprégné de jus d’hibiscus. Cette technique est faite car le jus d’hibiscus est riche en mucilage donnant après séchage une masse gommeuse et hygroscopique non granuleuse. Le sucre permet donc d’obtenir une forme cristalline granuleuse, mais cette forme est riche en sucre ajouté qui est néfaste pour la santé. L’objectif de ce travail à été de proposer une formulation sèche facilement soluble dans l’eau en transforment l’extrait sec gommeuse en pilule effervescente par ajout d’acide citrique et de bicarbonate de sodium.
Pengaruh Kompetensi Pedagogik Guru Terhadap Pelaksanaan Evaluasi Pembelajaran Siswa
Authors: Aren Aren , Aryani Rita 
Published: July 2023

Tujuan penelitian ini dilakukan untuk mengetahui pengaruh kompetensi pedagogik guru terhadap pelaksanaan evaluasi pembelajaran siswa/i di SMK Korpri Kota Bekasi kelas XI Akuntansi. Jenis penelitian ini mengunakan metode kuantitatif assosiatif, dengan mengunakan penelitan asosiasi korelasional. Populasi dalam penelitian ini adalah serluruh siswa/I kelas XI di SMK Korpri Kota Bekasi. Teknik pengabilan sampel yang digunakan dalam penelitian ini adalah total sampling. Teknik pengumpulan data dalam penelitian ini mengunakan angket, observasi, dan dokumentasi. Teknik analisis data mengunakan analisis rergresi linear sederhana dengan alat bantuan sofwer yaitu dengan program SPSS versi 21. Hasil penelitian ini menunjuk bahwa uji signifikansi koefisien korelasi (r xy) = 0,283 dan Fhit (f change) =12,647 dengan p-value =0,001< 0,05. Hal ini HO ditolak. Koefisien korelasi X danY adalah berarti atau signifikan. Dari hasil analisis didapat kompotensi pedagogik guru berpengaruh terhadap pelaksanaan evaluasi pembelajaran di kelas XI Akuntansi, hal ini dapat dilihat dari thit dan p-value lebih kecl dari 0,05%. Oleh sebab itu dapat di interpretasikan bahwa kompotensi pedagogik guru berpengaruh positif terhadap pelaksanaan evaluasi pembelajaran dikelas xi mata pelajaran akuntansi yaitu: R Square = 0,283 atau sebesar 28,3%.
Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers
Authors: Nagakura Ken-ichi , Sato Sakura , Shinahara Wakako , Kido Hiroshi , Fujita Hidetoshi , Yanai Takanori , Akiyama Nao , Futamura Masaki , Koga Hiroshi , Fujiwara Michimasa , Kaneko Hideo , Taniguchi Hiroaki , Makita Eishi , Takahashi Kyohei , Yanagida Noriyuki , Ebisawa Motohiro , Urashima Mitsuyoshi 
Published: July 2023

ImportanceEgg introduction in infants at age 4 to 6 months is associated with a lower risk of immunoglobulin E–mediated egg allergy (EA). However, whether their risk of EA at age 12 months is affected by maternal intake of eggs at birth is unknown.ObjectiveTo determine the effect of maternal egg intake during the early neonatal period (0-5 days) on the development of EA in breastfed infants at age 12 months.Design, Setting, and ParticipantsThis multicenter, single-blind (outcome data evaluators), randomized clinical trial was conducted from December 18, 2017, to May 31, 2021, at 10 medical facilities in Japan. Newborns with at least 1 of 2 parents having an allergic disease were included. Neonates whose mothers had EA or were unable to consume breast milk after the age of 2 days were excluded. Data were analyzed on an intention-to-treat basis.InterventionsNewborns were randomized (1:1) to a maternal egg consumption (MEC) group, wherein the mothers consumed 1 whole egg per day during the first 5 days of the neonate’s life, and a maternal egg elimination (MEE) group, wherein the mothers eliminated eggs from their diet during the same period.Main Outcomes and MeasuresThe primary outcome was EA at age 12 months. Egg allergy was defined as sensitization to egg white or ovomucoid plus a positive test result in an oral food challenge or an episode of obvious immediate symptoms after egg ingestion.ResultsOf the 380 newborns included (198 [52.1%] female), 367 (MEC: n = 183; MEE: n = 184) were followed up for 12 months. On days 3 and 4 after delivery, the proportions of neonates with ovalbumin and ovomucoid detection in breast milk were higher in the MEC group than in the MEE group (ovalbumin: 10.7% vs 2.0%; risk ratio [RR], 5.23; 95% CI, 1.56-17.56; ovomucoid: 11.3% vs 2.0%; RR, 5.55; 95% CI, 1.66-18.55). At age 12 months, the MEC and MEE groups did not differ significantly in EA (9.3% vs 7.6%; RR, 1.22; 95% CI, 0.62-2.40) or sensitization to egg white (62.8% vs 58.7%; RR, 1.07; 95% CI, 0.91-1.26). No adverse effects were reported.Conclusions and RelevanceIn this randomized clinical trial, EA development and sensitization to eggs were unaffected by MEC during the early neonatal period.Trial RegistrationUMIN Clinical Trials Registry: UMIN000027593