bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline mismatch repair (MMR) variants
Authors: Stundon Jennifer L , Ijaz Heba , Gaonkar Krutika S , Kaufman Rebecca S , Jin Run , Karras Anastasios , Vaksman Zalman , Kim Jung , Corbett Ryan J , Lueder Matthew R , Miller Daniel P , Guo Yiran , Santi Mariarita , Li Marilyn , Lopez Gonzalo , Storm Phillip B , Resnick Adam C , Waanders Angela J , MacFarland Suzanne P , Stewart Douglas R , Diskin Sharon J , Rokita Jo Lynne , Cole Kristina A 
Published: December 2022

Abstract

Background
To achieve replicative immortality, most cancers develop a telomere maintenance mechanism, such as reactivation of telomerase or alternative lengthening of telomeres (ALT). There are limited data on the prevalence and clinical significance of ALT in pediatric brain tumors, and ALT-directed therapy is not available.

Methods
We performed C-circle analysis (CCA) on 579 pediatric brain tumors that had corresponding tumor/normal whole genome sequencing through the Open Pediatric Brain Tumor Atlas (OpenPBTA). We detected ALT in 6.9% (n = 40/579) of these tumors and completed additional validation by ultrabright telomeric foci in situ on a subset of these tumors. We used CCA to validate TelomereHunter for computational prediction of ALT status and focus subsequent analyses on pediatric high-grade gliomas (pHGGs) Finally, we examined whether ALT is associated with recurrent somatic or germline alterations.

Results
ALT is common in pHGGs (n = 24/63, 38.1%), but occurs infrequently in other pediatric brain tumors (&lt;3%). Somatic ATRX mutations occur in 50% of ALT+ pHGGs and in 30% of ALT− pHGGs. Rare pathogenic germline variants in mismatch repair (MMR) genes are significantly associated with an increased occurrence of ALT.

Conclusions
We demonstrate that ATRX is mutated in only a subset of ALT+ pHGGs, suggesting other mechanisms of ATRX loss of function or alterations in other genes may be associated with the development of ALT in these patients. We show that germline variants in MMR are associated with the development of ALT in patients with pHGG.
Duration of Chemotherapy-induced Nausea and Vomiting (CINV) as a Predictor of Recurrent CINV in Later Cycles
Authors: Navari Rudolph , Binder Gary , Molasiotis Alex , Herrstedt Jørn , Roeland Eric J , Ruddy Kathryn J , LeBlanc Thomas W , Kloth Dwight D , Klute Kelsey A , Papademetriou Eros , Schmerold Luke , Schwartzberg Lee 
Published: December 2022

AbstractBackgroundThe relationship between CINV duration and recurrence in subsequent cycles is largely unstudied. Our objective was to determine if patients experiencing CINV in their first cycle of chemotherapy (C1) would face increased risk of CINV in later cycles and whether the duration of the CINV would predict increased risk of recurrence.Patients and MethodsUsing data from a previously reported phase III trial, we assessed patients’ recurrence of breakthrough CINV after antiemetic prophylaxis for anthracycline+cyclophosphamide (AC) for breast cancer, comparing C1 short CINV vs. extended CINV as a secondary analysis. Complete response (CR) and CINV duration were primary and secondary endpoints, respectively. CR was considered prophylaxis success; lack of CR was considered treatment failure (TF).ResultsAmong 402 female patients, 99 (24.6%) had TF in C1 (TF1). The remaining 303 patients (CR1) had ≥93% CR rates in each subsequent cycle, while the 99 patients with TF1 had TF rates of 49.8% for cycles 2-4 (P &lt; .001). The 51 patients with extended TF (≥3 days) in C1 had recurrent TF in 73/105 later cycles (69.5%, P &lt; .001), while the 48 patients with short TF (1-2 days) in C1 had recurrent TF in 33/108 later cycles (30.6%). The relative risk of recurrence after C1 extended TF was 2.28 (CI 1.67-3.11; P &lt; .001) compared to short TF.ConclusionsProphylaxis success in C1 led to &gt;90% repeat success across cycles of AC-based chemotherapy. For patients with breakthrough CINV, extended duration strongly predicted recurrent CINV. The duration of CINV should be closely monitored, and augmenting antiemetic prophylaxis considered for future cycles when extended CINV occurs.
Hip Hop Dance and Injury Prevention
Authors: Ingram Tony 
Published: December 2022

Abstract
This chapter reviews the fundamentals of dance injury prevention with special emphasis on its application to breaking. Elements of training such as how to practice, exercise, warm up, and stretch safely and effectively are reviewed. The information is based on the research done on dance and sports sciences up until 2015. Advances in injury prevention from sports science are discussed, and the limitations of applying such research to b-boys and b-girls are considered. Similarly, limitations of the existing dance-injury prevention literature are discussed given that research typically investigates classically trained dancers. Because research typically involves group averages, an important discussion concerns how to personalize training to meet the specific needs of individual dancers. Finally, topics of further inquiry for those planning research on this unique population of dancers are suggested
The Phenomenological Turn in Romanian Spectralism
Authors: Hayes Aaron 
Published: December 2022

Abstract
This chapter approaches the music of Romanian composers Ana Maria Avram and Iancu Dumitrescu from a phenomenological perspective that moves away from a reliance on science and technology characteristic much of French spectralism. These composers have expressed their interest in a shift away from the scientific analysis of timbre and sound toward certain post-Husserlian ideas, and this change in focus coincides with recent work in transformational analysis, studies of embodiment and expression, and the ontology of music. Employing a number of concepts from these fields, including the work of Gilbert Simondon, this article focuses especially on Avram’s concept of transformation, and proposes that her music initiates a phenomenology of musical stability that corrects the simplified reification of musical objects: not simply by opposing stable and unstable, but by also employing multistability and metastability in music.
Reconstructing the Creative Process
Authors: Everist Mark 
Published: December 2022

Abstract
Music for the stage involves many more cultural artifacts than are evoked by such terms as “opera.” Considering a broader span of works than just continuous or through-composed opera brings into consideration such genres as opéra comique, Syngestykker, and Posse mit Gesang. With this change of perspective comes the possibility of reflecting on a wider variety of agents (in the terms of the sociologist Howard Becker) than the traditional librettist-composer paradigm permits. These basic principles are explored through two examples. The comédie-vaudeville: Le quaker et la danseuse, with its generic use of borrowed material, throws down a challenge to conventional views of authorship, and in doing so extends the array of agents under consideration. This study is juxtaposed with an examination of Wagner’s Tristan und Isolde, where the broader context of the work’s immediate reception reveals an equally broad range of agents engaged in the projection of the work.
The Evolving Ideas of Beethoven’s Creative Process
Authors: Kinderman William , Sallis Friedemann 
Published: December 2022

Abstract
The primary goal of this article is to examine some of the contexts within which critics and scholars have studied Beethoven’s Tempest Sonata, op. 31 no. 2, as well as the creative process pertaining to it. It will show that the diversity of analytical and interpretative outcomes is a consequence of the answers being sought and of the historical contexts within which the questions were posed. In so doing, it sheds light on the complex relationships that entangle the reception of Beethoven’s music, on the one hand, and the development of scholarship on compositional technique and the creative process, on the other.
Watershed memory amplified the Oroville rain-on-snow flood of February 2017
Authors: Haleakala Kayden , Brandt W Tyler , Hatchett Benjamin J , Li Dongyue , Lettenmaier Dennis P , Gebremichael Mekonnen 
Published: December 2022

AbstractMountain snowpacks are transitioning to experience less snowfall and more rainfall as the climate warms, creating more persistent low- to no-snow conditions. This precipitation shift also invites more high-impact rain-on-snow (ROS) events, which have historically yielded many of the largest and most damaging floods in the western United States. One such sequence of events preceded the evacuation of 188,000 residents below the already-damaged Oroville Dam spillway in February 2017 in California’s Sierra Nevada. Prior studies have suggested that snowmelt during ROS dramatically amplified reservoir inflows. However, we present evidence that snowmelt may have played a smaller role than previously documented (augmenting terrestrial water inputs by 21%). A series of hydrologic model experiments and subdaily snow, soil, streamflow, and hydrometeorological measurements demonstrate that direct, “passive” routing of rainfall through snow, and increasingly efficient runoff driven by gradually wetter soils can alternatively explain the extreme runoff totals. Our analysis reveals a crucial link between frequent winter storms and a basin’s hydrologic response—emphasizing the role of soil moisture “memory” of within-season storms in priming impactful flood responses. Given the breadth in plausible ROS flood mechanisms, this case study underscores a need for more detailed measurements of soil moisture along with in-storm changes to snowpack structure, extent, energy balance, and precipitation phase to address ROS knowledge gaps associated with current observational limits. Sharpening our conceptual understanding of basin-scale ROS better equips water managers moving forward to appropriately classify threat levels, which are projected to increase throughout the mid-21st century.
Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata
Authors: Tsai Jerry , Gori Sadakatali , Alt Jesse , Tiwari Sandhya , Iyer Jitesh , Talwar Rashmi , Hinsu Denish , Ahirwar Kailash , Mohanty Swayam , Khunt Chintan , Sutariya Brijesh , Jani Kaushal , Venkatasubbaiah Venkatesha , Patel Ashok , Meghapara Jasmin , Joshi Kaushal , Sahu Rajanikanta , Rana Vijay , Nigade Prashant , Talluri Ravi S , Murty Kadiyala V S N , Joshi Kiritkumar , Ramanathan Vikram , Li Ang , Islam Nasif , Snajdr Ivan , Majer Pavel , Rais Rana , Slusher Barbara S , Garza Luis A 
Published: December 2022

Abstract
Alopecia areata is a chronic hair loss disorder that involves autoimmune disruption of hair follicles by CD8+ T cells. Most patients present with patchy hair loss on the scalp that improves spontaneously or with topical and intralesional steroids, topical minoxidil, or topical immunotherapy. However, recurrence of hair loss is common, and patients with extensive disease may require treatment with oral corticosteroids or oral Janus kinase (JAK) inhibitors, both of which may cause systemic toxicities with long-term use. Itaconate is an endogenous molecule synthesized in macrophages that exerts anti-inflammatory effects. To investigate the use of itaconate derivatives for treating alopecia areata, we designed a prodrug of 4-methyl itaconate (4-MI), termed SCD-153, with increased lipophilicity compared to 4-MI (CLogP 1.159 vs. 0.1442) to enhance skin and cell penetration. Topical SCD-153 formed 4-MI upon penetrating the stratum corneum in C57BL/6 mice and showed low systemic absorption. When added to human epidermal keratinocytes stimulated with polyinosinic-polycytidylic acid (poly I:C) or interferon (IFN)γ, SCD-153 significantly attenuated poly I:C-induced interleukin (IL)-6, Toll-like receptor 3, IL-1β, and IFNβ expression, as well as IFNγ-induced IL-6 expression. Topical application of SCD-153 to C57BL/6 mice in the resting (telogen) phase of the hair cycle induced significant hair growth that was statistically superior to vehicle (dimethyl sulfoxide), the less cell-permeable itaconate analogues 4-MI and dimethyl itaconate, and the JAK inhibitor tofacitinib. Our results suggest that SCD-153 is a promising topical candidate for treating alopecia areata.
A machine learning approach reveals features related to clinicians’ diagnosis of clinically relevant knee osteoarthritis
Authors: Wang Qiuke , Runhaar Jos , Kloppenburg Margreet , Boers Maarten , Bijlsma Johannes W J , Bacardit Jaume , Bierma-Zeinstra Sita M A ,   The CREDO Experts Group, Aerts-Lankhorst N E , Agricola R , Bastick A N , van Bentveld R D W , van den Berg P J , Bijsterbosch J , de Boer A , Boers M , Bohnen A M , Boonen A E R C H , Bos P K , Boymans T A E J , Breedveldt-Boer H P , Brouwer R W , Colaris J W , Damen J , Elshout G , Emans P J , Enthoven W T M , Frölke E J M , Glijsteen R , van der Heide H J C , Huisman A M , van Ingen R D , Jacobs M L , Janssen R P A , Kevenaar P M , van Koningsbrugge M A , Krastman P , Kuchuk N O , Landsmeer M L A , Lems W F , van der Linden H M J , van Linschoten R , Mahler E A M , van Meer B L , Meuffels D E , Noort-van der Laan W H , van Ochten J M , van Oldenrijk J , Pols G H J , Piscaer T M , Rijkels-Otters J B M , Riyazi N , Schellingerhout J M , Schers H J , Schouten B W V , Snijders G F , van Spil W E , Stitzinger S A G , Tolk J J , van Trier Y D M , Vis M , Voorbrood V M I , de Vos B C , de Vries A 
Published: December 2022

Abstract

Objectives
To identify highly ranked features related to clinicians’ diagnosis of clinically relevant knee OA.

Methods
General practitioners (GPs) and secondary care physicians (SPs) were recruited to evaluate 5–10 years follow-up clinical and radiographic data of knees from the CHECK cohort for the presence of clinically relevant OA. GPs and SPs were gathered in pairs; each pair consisted of one GP and one SP, and the paired clinicians independently evaluated the same subset of knees. A diagnosis was made for each knee by the GP and SP before and after viewing radiographic data. Nested 5-fold cross-validation enhanced random forest models were built to identify the top 10 features related to the diagnosis.

Results
Seventeen clinician pairs evaluated 1106 knees with 139 clinical and 36 radiographic features. GPs diagnosed clinically relevant OA in 42% and 43% knees, before and after viewing radiographic data, respectively. SPs diagnosed in 43% and 51% knees, respectively. Models containing top 10 features had good performance for explaining clinicians’ diagnosis with area under the curve ranging from 0.76–0.83. Before viewing radiographic data, quantitative symptomatic features (i.e. WOMAC scores) were the most important ones related to the diagnosis of both GPs and SPs; after viewing radiographic data, radiographic features appeared in the top lists for both, but seemed to be more important for SPs than GPs.

Conclusions
Random forest models presented good performance in explaining clinicians’ diagnosis, which helped to reveal typical features of patients recognized as clinically relevant knee OA by clinicians from two different care settings.
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces liver lipid metabolism disorder via the ROS/AMPK/CD36 signaling pathway
Authors: Cong Yewen , Hong Yujing , Wang Dandan , Cheng Pei , Wang Zhisheng , Xing Changming , Sun Wenxing , Xu Guangfei 
Published: December 2022

Abstract2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is widely considered as the most toxic and common carcinogen in the world. Exposure to TCDD causes liver lipid metabolism disorder and steatosis. However, the molecular mechanism of TCDD-induced liver lipid accumulation is not completely clear. Here, we found that a 5 μg/kg TCDD exposure for 3 weeks induced hepatocyte lipid deposition, increased CD36 expression, and promoted AMP-activated protein kinase (AMPK) ɑ phosphorylation in the liver of C57BL/6J mice. Furthermore, sulfo-N-succinimidyl oleate, a CD36 inhibiter, blunted TCDD-induced lipid deposition in Huh7 cells, confirming the critical role of CD36 in TCDD-induced hepatic steatosis. In terms of molecular mechanisms, we found that TCDD exposure increased reactive oxygen species (ROS) levels in Huh7 cells, which activated AMPK. Moreover, the activated AMPK upregulated CD36 expression. Therefore, we can see that the increase in CD36 expression induced by TCDD was regulated by ROS/AMPK/CD36 signaling pathway. Our results help to clarify the molecular mechanism of TCDD-induced hepatic steatosis.
Treatment of Lentigines: A Systematic Review
Authors: Mukovozov Ilya , Roesler Jordanna , Kashetsky Nadia , Gregory Allison 
Published: December 2022

BACKGROUND
Treatments for solar lentigines include topical and physical therapies, including chemical peels, lasers, intense pulsed light, and cryotherapy. A direct comparison of treatment methods and their efficacy is lacking.

OBJECTIVE
To compare treatment efficacy and adverse events for different treatment modalities for lentigines.

METHODS
Cochrane, MEDLINE, and Embase databases were searched on August 25, 2021. Studies were included if they met our predetermined population, intervention, comparator, outcomes, study design framework. Results are presented in narrative form.

RESULTS
Forty-eight articles met the inclusion criteria, representing a total of 1,763 patients. Overall, combination-based treatments showed the greatest frequency of cases with complete response (65%, n = 299/458), followed by laser-based treatments (43%, n = 395/910), topical retinoids (21%, n = 12/57), cryotherapy (15%, n = 25/169), and peels (6%, n = 8/125). Adverse events occurred most commonly while using topical retinoids (82%, n = 23/28), followed by combination-based treatments (39%, n = 184/466), cryotherapy (33%, n = 47/144), laser-based treatments (23%, n = 173/738), and peels (19%, n = 21/110).

CONCLUSION
Despite heterogeneity of included study designs, patient populations, treatment regimens, and outcome measures, our results suggest that combination-based treatments and laser-based treatments were the most efficacious treatment modalities. Although cryotherapy was previously considered first-line, our results show that it has substantially lower pooled response rates compared with other treatment modalities.
Recurrent Lisch Epithelial Corneal Dystrophy Treated With 5-Fluorouracil: A Case Report and Review of the Literature
Authors: Amer Mona M. , Arze Karen , Galor Anat , Sayegh Yoseph , Dubovy Sander S. , Karp Carol L. 
Published: December 2022

Purpose:
The aim of the study was to describe a case of Lisch epithelial corneal dystrophy (LECD), review its clinical and histopathological features and diagnostic imaging, and introduce a novel treatment approach using topical 5-fluorouracil (5-FU).

Methods:
A 65-year-old woman presented with a recurrent left-sided corneal lesion consistent with LECD. The lesion was evaluated clinically, with high-resolution optical coherence tomography (HR-OCT), and histologically. The lesion was successfully treated with two 1-week cycles of topical 5-FU.

Results:
Slit-lamp examination showed an opalescent, whorl-shaped corneal lesion. HR-OCT revealed a trapezoidal area of normal thickness epithelial hyperreflectivity. Histopathology demonstrated a mucosal epithelium with foamy cytoplasm and increased cell size consistent with LECD. Treatment with topical 5-FU resulted in marked clearance of the corneal lesion on slit-lamp examination and HR-OCT.

Conclusions:
5-FU may be considered as a treatment option for LECD.
Test-Retest Reliability and Criterion Validity of the Spanish Version of Two Motor Imagery Questionnaires in People With Parkinson Disease
Authors: Moreno-Verdú Marcos , Ferreira-Sánchez María del Rosario , Martín-Casas Patricia , Atín-Arratibel María de los Ángeles 
Published: December 2022

Background and purpose:
The Kinesthetic and Visual Imagery Questionnaire (KVIQ) and the Movement Imagery Questionnaire-Revised Second Version (MIQ-RS) are measurement instruments that assess motor imagery vividness. The aim of this study was to examine the validity and reliability of the Spanish KVIQ and MIQ-RS in people with Parkinson disease (PD).

Methods:
A longitudinal descriptive study was conducted following the COSMIN standards. Thirty-five people with idiopathic PD were evaluated twice (7-15 days apart) with the Spanish KVIQ and MIQ-RS. Structural validity, internal consistency, test-retest reliability (ICC), standard error of measurement (SEM), smallest detectable change (SDC), and criterion validity of the MIQ-RS and KVIQ long (KVIQ-20), short (KVIQ-10), and extended (KVIQ-34) versions and their subscales (if pertinent) were tested.

Results:
Factor analysis was satisfactory for the MIQ-RS, KVIQ-20, and KVIQ-10, providing evidence of their 2-dimensional structure. Evidence of the structural validity of the KVIQ-34 was not confirmed and thus was analyzed as an overall score. Revelle's ω > 0.9 showed excellent internal consistency. Test-retest reliability was moderate (ICC = 0.58-0.75) and higher for all visual subscales. SEM and SDC were up to 14.39% and 39.89% of the scores, respectively. Criterion validity between questionnaires and subscales was strong (Spearman's r > 0.7).

Discussion and Conclusions:
The results provide evidence for the validity and reliability of the Spanish MIQ-RS, KVIQ-20, and KVIQ-10 to assess motor imagery vividness in people with PD, whereas the KVIQ-34 should only be interpreted as an overall score. Psychometric, procedural, and practical features of the questionnaires should be considered when applying into clinical practice.

Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A401).
“We’ve Got This”: Middle-Aged and Older Couples’ Satisfying Relationships and We-Talk Promote Better Physiological, Relational, and Emotional Responses to Conflict
Authors: Shrout M. Rosie , Wilson Stephanie J. , Renna Megan E. , Madison Annelise A. , Kiecolt-Glaser Janice K. 
Published: December 2022

ABSTRACT

Objective
Conflict poses multiple relational and health risks. Dyadic stress theories suggest satisfaction and communication alter cardiovascular and autonomic function, key pathways from troubled relationships to poor health. However, “we-talk,” a positive communication pattern, can strengthen relationships and promote health. We examined how each spouse’s satisfaction and we-talk were related to conflict’s physiological, relational, and emotional toll.

Methods
Married couples (n = 107 couples, 214 individuals, ages 40–87 years) who were mostly White, highly educated, and higher-income Americans in different-gender relationships engaged in 20-minute conflict discussions while wearing monitors to assess heart rate variability (HRV). Spouses rated their closeness immediately after conflict and their conflict rumination 2 hours later. Conflict transcriptions measured we-talk, or the proportion of first-person plural pronouns (we, us, our).

Results
Satisfied spouses or those in mutually satisfying relationships had higher HRV during conflict (b = 0.0001, p = .049), felt closer immediately after conflict (b = 0.07, p < .001), and ruminated less about the conflict 2 hours later (b = −0.26, p = .026). Spouses’ HRV was highest (b = 0.0002, p = .002) and rumination was lowest (b = −0.49, p = .019) when they or their partners were satisfied and used we-talk more often. Women’s HRV (b = 0.0001, p = .035) and rumination (b = −0.01, p = .02) benefited when both spouses were satisfied, as did closeness when women were satisfied (b = 0.10, p < .001). Men’s closeness benefited when they (b = 0.04, p = .003) or their wives (b = 0.04, p = .002) were satisfied.

Conclusions
The combination of mutually satisfying relationships and we-talk was associated with better relational and health outcomes after conflict. These findings are important for middle-aged and older couples whose relationships are central to their health.