bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomimicry in Building Architecture
Authors: Martino Bryan 
Published: May 2023

Biomimicry— design inspired by the functional genius of nature— is a concept becoming more and more prevalent in fields of material science, architecture, and other sciences. Yet, the construction industry does not understand how to build with biomimetic materials, nor understand their biological precedents. Much of this has to do with the familiar use of traditional, high-carbon materials, and lack of collaboration between contractors and biologists. Thus, this study offers a comprehensive exploration of how well biomimetics is translated into the material and structural qualities of buildings. Furthermore, this study aims to provide insight on how to fill the gap between novel technologies and commercial building development. As a result of this effort, architects and engineers will understand how to leverage nature to make buildings more sustainable. In the first part of this document, biomimicry is contextualized and the scope of this investigation is explained. The second part transitions into a detailed exploration of biological models, processes, and their material feasibility in today’s industry. Lastly, this study evaluates evidence from part two to compare how well biomimetic precedents are optimized based on available research. Evidence suggests that a paradigm shift towards system thinking is paramount to the integration of nature’s genius into a sustainable built environment.
Lay Summary
Copying nature's patterns, forms, and processes in new building technology is one way to achieve more efficient material and energy use. However, there are two key obstacles to sustainable building: lack of collaboration between industries, and short-term gain. This investigation explores how we can overcome these obstacles to bring more innovative solutions into the built environment. Key ideas about the green building are discussed, then existing research is explained. In the end, evidence is evaluated to demonstrate the potential for developing natural models in the real world.
To see the complete thesis, please visit https://scholar.colorado.edu/concern/undergraduate_honors_theses/nk322f51x.
Profitability Determinants of Transport Service and Warehouse Enterprises
Authors: Derkacz Arkadiusz J. , Dudziak Agnieszka , Stopka Ondrej , Stopková Mária 
Published: May 2023

The main purpose of the research is to identify differences in the factors determining changes in the return on capital (ROE) of transport and warehouse enterprises in individual voivodeships in Poland. The research used the ROE decomposition method which was justified by mathematical aspects. It paid attention on the decomposition of relative differences shaping the changes in this specific indicator. The substantive basis is the modified 5-factor Du Pont model. This method allowed for analysing relative changes in three decision areas. These areas encompass operational, financial, and tax management. The findings confirmed that the differences in individual voivodeships compared to the entire section H in Poland result mainly from financial management. However, the examined differentiation was not dependent on tax management. The presented research results can represent the basis for the strategy of corporate management in section H in positioning against competitive enterprises in Poland. The research also allows for a macroeconomic analysis of the phenomena occurring in the transport as well as warehousing sector, especially in terms of changes in their profitability.
Komunikasi Anonim Dalam Pemanfaatan Autobase Sebagai Media Informasi (Studi Netnografi pada Pengguna Akun @jogjamnfs di Twitter)
Authors: Cesar Heppy Prissilia , Aprilia Monika 
Published: May 2023

Abstrak. Fungsi Twitter telah berkembang menjadi sebuah platform yang berguna untuk berbagai macam hal dengan munculnya akun autobase di Twitter. Autobase mengumpulkan orang-orang dengan kesukaan ataupun minat yang sama untuk saling berkumpul, berdiskusi dan berbagi informasi mengenai hal yang menjadi topik di akun base tersebut. Pengguna dapat mengirim pesan atau informasi melalui direct message yang terdapat pada akun autobase yang diikuti. Pesan atau yang lebih akrab disebut dengan menfess akan terkirim secara otomatis dan muncul di timeline yang dapat direspon oleh pengikut akun tersebut. Penelitian ini bertujuan untuk menganalisis komunikasi secara anonim dalam pemanfaatan akun @jogjamnfs sebagai media informasi dengan melibatkan tiga pandangan, yaitu: admin, pengirim pesan, dan penerima pesan. Penelitian yang dilakukan merupakan penelitian kualitatif dengan studi netnografi. Teknik pengumpulan data didalam penelitian ini yaitu dengan melakukan wawancara dan observasi. Peneliti akan mewawancarai informan sebanyak 5 orang yaitu satu admin, dua pengirim menfess, dan dua penerima menfess melalui pesan yang dikirimkan melalui fitur direct massage yang ada didalam Twitter. Selanjutnya, peneliti akan melakukan teknik analisis data yaitu dengan reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa akun @jogjamnfs bermanfaat sebagai sarana media informasi dan hal lain dalam lingkup Yogyakarta bagi pengikut akun tersebut. Dengan menggunakan sistem yang anonim memberikan kenyaman bagi para pengikut akun @jogjamnfs untuk saling berkirim dan menjawab menfess di akun @jogjamnfs.Kata Kunci: Anonimitas, Autobase, Menfess, Twitter
Strategi Pelaksanaan Coorporate Social Responsibility Dan Kendala Pelaksanaannya Pada Pt. Mifa Bersaudara
Authors: Tarigan Beny Primza , Wardana Nazwa Azura Citra 
Published: May 2023

Coorporate Social Responsibility (CSR) merupakan program wajib bagi suatu perusahaan dalam keberadaannya di tengah lingkungan masyarakat. Pengaturan tentang CSR juga terdapat dalam Undang-Undang. CSR didasarkan atas kepentingan stakeholders perusahaan dan untuk meningkatkan reputasi perusahaan. Dalam penerapannya juga tidak jarang terkendala dan akhirnya gagal dalam penerapan program CSR. Kendala yang dirasakan perusahaan berasal dari internal dan eksternal perusahaan itu sendiri. Diperlukan strategi yang juga harus dikombinasikan dengan Sumber Daya Manusia perusahaan yang berkualitas untuk mengatasi kendala tersebut dan untuk melaksanakan CSR dengan baik. Strategi yang baik adalah strategi yang dikomunikasikan kepada masyarakat sasaran. CSR tidak selesai pada output, tetapi pada outcome. CSR yang baik selalu identik dengan pemberdayaan, keberlanjutan, dan pembentukan mental masyarakat agar mampu berkembang lebih luas lagi. Terdapat juga kesalahan pengetahuan dan interpretasi perusahaan mengenai CSR dalam praktiknya yang mengakibatkan gagalnya program CSR. Jurnal ini bertujuan untuk mengetahui strategi pelaksanaan CSR perusahaan yang sudah berhasil melakukannya. Selain itu, bertujuan juga mengetahui kendala yang dialami perusahaan ketika melaksanakannya. Dengan mengetahui kendala, maka akan ditemukan solusi yang baik agar CSR selanjutnya dapat berjalan dengan baik. Metode yang digunakan dalam penelitian ini adalah studi kepustakaan. Hasil penelitian menunjukkan hasil pemahaman dan interpretasi baru tentang kebervariatifan CSR dalam Undang-Undang sehingga pelaksanaannya dapat dijalankan dengan baik.
Black Box Testing of the "Hybrid Engine" Application Using Boundary Value Analysis Technique
Authors: Megawati Citra Dewi , Miwa Nina Deskartika , Palevi Bima Romadhon Parada Dian 
Published: May 2023

The "Hybrid Engine" application is an introduction to a hybrid engine that is packaged attractively and can be accessed online, this application is very important for conveying information about hybrid engines, if an error occurs in the functional application there can be misunderstandings about the information conveyed. Therefore it is necessary to test to ensure the quality of the application that has been produced. Testing is an evaluation process of assessing the functional quality of software to check whether the software meets the expected process or not. Functional processes that have not been maximized can cause inequalities in the data information to be displayed. Applications that have been designed must go through the testing stages to ensure the level of functional quality. Of the several types of black box testing methods, one of them is Boundary Value Analysis. The method tests the maximum and minimum number of digits to produce a valid value and is easy enough to test "hybrid engine" applications. The first stage carried out in this research is to identify the functionality to be processed and ensure that the maximum and minimum number of digits matches the predetermined system arrangement. The result of applying the method used is that the quality of the application is under its function, and can be utilized properly by the user. The results of the Boundary Value Analysis test show that the application is following the expected system and instructions with a success percentage of 78.245615%.
Low-intensity pulsed ultrasound reduces lymphedema by regulating macrophage polarization and enhancing microcirculation
Authors: Liu Zihao , Li Jia , Bian Yu , Zhang Xiaojie , Cai Xiaojun , Zheng Yuanyi 
Published: May 2023

Background: Conventional therapies reduce lymphedema but do not cure it because they cannot modulate the pathophysiology of secondary lymphedema. Lymphedema is characterized by inflammation. We hypothesized that low-intensity pulsed ultrasound (LIPUS) treatment could reduce lymphedema by enhancing anti-inflammatory macrophage polarization and microcirculation.Methods: The rat tail secondary lymphedema model was established through the surgical ligation of lymphatic vessels. The rats were randomly divided into the normal, lymphedema, and LIPUS treatment groups. The LIPUS treatment (3 min daily) was applied 3 days after establishing the model. The total treatment period was 28 days. Swelling, fibro adipose deposition, and inflammation of the rat tail were evaluated by HE staining and Masson’s staining. The photoacoustic imaging system and laser Doppler flowmetry were used to monitor microcirculation changes in rat tails after LIPUS treatment. The cell inflammation model was activated with lipopolysaccharides. Flow cytometry and fluorescence staining were used to observe the dynamic process of macrophage polarization.Results: After 28 days of treatment, compared with the lymphedema group, the tail circumference and subcutaneous tissue thickness of rats in the LIPUS group were decreased by 30%, the proportion of collagen fibers and the lymphatic vessel cross-sectional area was decreased, and tail blood flow was increased significantly. Cellular experiments revealed a decrease in CD86+ macrophages (M1) after LIPUS treatment.Conclusion: The transition of M1 macrophage and the promotion of microcirculation could be responsible for the beneficial effect of LIPUS on lymphedema.
Advances in epidemiological status and pathogenesis of dental fluorosis
Authors: Zhang Kaiqiang , Lu Zhenfu , Guo Xiaoying 
Published: May 2023

Fluoride is commonly consider as a “double-edged sword” because low consumption of fluoride can effectively prevent dental caries, but excessive consumption of fluoride can cause fluorosis. Dental fluorosis (DF) is a characteristic feature of fluorosis in the oral cavity that is manifested as tooth color changes and evident enamel defect. Presently, the pathogenesis of DF remains unclear. Herein, we have summarized the research progress in the pathogenesis and mechanism of DF in the past 5 years.
Joint conditional generative adversarial networks for eyelash artifact removal in ultra-wide-field fundus images
Authors: Zhang Jiong , Sha Dengfeng , Ma Yuhui , Zhang Dan , Tan Tao , Xu Xiayu , Yi Quanyong , Zhao Yitian 
Published: May 2023

Background: Ultra-Wide-Field (UWF) fundus imaging is an essential diagnostic tool for identifying ophthalmologic diseases, as it captures detailed retinal structures within a wider field of view (FOV). However, the presence of eyelashes along the edge of the eyelids can cast shadows and obscure the view of fundus imaging, which hinders reliable interpretation and subsequent screening of fundus diseases. Despite its limitations, there are currently no effective methods or datasets available for removing eyelash artifacts from UWF fundus images. This research aims to develop an effective approach for eyelash artifact removal and thus improve the visual quality of UWF fundus images for accurate analysis and diagnosis.Methods: To address this issue, we first constructed two UWF fundus datasets: the paired synthetic eyelashes (PSE) dataset and the unpaired real eyelashes (uPRE) dataset. Then we proposed a deep learning architecture called Joint Conditional Generative Adversarial Networks (JcGAN) to remove eyelash artifacts from UWF fundus images. JcGAN employs a shared generator with two discriminators for joint learning of both real and synthetic eyelash artifacts. Furthermore, we designed a background refinement module that refines background information and is trained with the generator in an end-to-end manner.Results: Experimental results on both PSE and uPRE datasets demonstrate the superiority of the proposed JcGAN over several state-of-the-art deep learning approaches. Compared with the best existing method, JcGAN improves PSNR and SSIM by 4.82% and 0.23%, respectively. In addition, we also verified that eyelash artifact removal via JcGAN could significantly improve vessel segmentation performance in UWF fundus images. Assessment via vessel segmentation illustrates that the sensitivity, Dice coefficient and area under curve (AUC) of ResU-Net have respectively increased by 3.64%, 1.54%, and 1.43% after eyelash artifact removal using JcGAN.Conclusion: The proposed JcGAN effectively removes eyelash artifacts in UWF images, resulting in improved visibility of retinal vessels. Our method can facilitate better processing and analysis of retinal vessels and has the potential to improve diagnostic outcomes.
Micro-segmental analysis of the entry pathway and distribution of zolpidem in hair from different scalp regions after a single dose
Authors: Ji Jiao-Jiao , Xu Duoqi , Yan Hui , Xiang Ping , Shen Min 
Published: May 2023

Introduction: Hair testing is well established for the assessment of past drug exposure; however, more research is needed to understand drug incorporation mechanisms and drug entry pathways into hair.Method: In this study, a micro-segmental LC–MS/MS method was used to analyze a 0.4 mm segment of hair after a single oral administration of zolpidem. Five single hairs were plucked at 1 day, 3 days, 7 days, and 28 days after administration from the vertex posterior of three subjects, and 5 single hairs were also plucked from the parietal, left temporal, and right temporal regions of the head at 28 days.Results and discussion: Proximal S1 (0–0.4 mm) in hair plucked at 1 day had the highest level of zolpidem at 1.5–2.4 pg/mm; much lower concentrations (&lt; 1 pg/mm) were detected at proximal S2–S8 (0.4–3.2 mm). The drug concentration decreased gradually in S1 for 7 days after drug intake and disappeared by 28 days, suggesting that the drug from the bloodstream initially combined with the hair follicle and then gradually moved to the hair tip as the hair grew. The zolpidem concentration–hair segment profiles exhibited a large peak (root side) and a small peak (tip side) for the four sampling times in all three subjects, indicating that drug incorporation in the hair bulb occurred mainly from the blood but probably also entered the hair through sweat and sebum. Zolpidem was also detected in all hairs from the vertex posterior in all three subjects but was not detected in 1 hair from the parietal region and 2 hairs from the left temporal region. The consistency in drug detection, drug concentration level, and peak position was better in hair from the vertex posterior than from the other three regions, indicating that the vertex posterior is a suitable sampling region for estimating drug intake.
Synthesis, in vitro biological assessment, and molecular docking study of benzimidazole-based thiadiazole derivatives as dual inhibitors of α-amylase and α-glucosidase
Authors: Khan Shoaib , Iqbal Shahid , Taha Muhammad , Hussain Rafaqat , Rahim Fazal , Shah Mazloom , Awwad Nasser S. , Ibrahium Hala A. , Alahmdi Mohammed Issa , Dera Ayed A. , Ullah Hayat , Bahadur Ali , Aljazzar Samar O. , Elkaeed Eslam B. , Rauf Muhammad 
Published: May 2023

The clinical significance of benzimidazole-containing drugs has increased in the current study, making them more effective scaffolds. These moieties have attracted strong research interest due to their diverse biological features. To examine their various biological significances, several research synthetic methodologies have recently been established for the synthesis of benzimidazole analogs. The present study aimed to efficiently and quickly synthesize a new series of benzimidazole analogs. Numerous spectroscopic techniques, including 1H-NMR, 13C-NMR, and HREI-MS, were used to confirm the synthesized compounds. To explore the inhibitory activity of the analogs against α-amylase and α-glucosidase, all derivatives (1–17) were assessed for their biological potential. Compared to the reference drug acarbose (IC50 = 8.24 ± 0.08 µM), almost all the derivatives showed promising activity. Among the tested series, analog 2 (IC50 = 1.10 ± 0.10 &amp; 2.10 ± 0.10 µM, respectively) displayed better inhibitory activity. Following a thorough examination of the various substitution effects on the inhibitory capacity of α-amylase and α-glucosidase, the structure-activity relationship (SAR) was determined. We looked at the potential mechanism of how active substances interact with the catalytic cavity of the targeted enzymes in response to the experimental results of the anti-glucosidase and anti-amylase. Molecular docking provided us with information on the interactions that the active substances had with the various amino acid residues of the targeted enzymes for this purpose.
Sterically wrapping of multi-resonant fluorophores: an effective strategy to suppress concentration quenching and spectral broadening
Authors: Xiaofeng Luo , Dongdong Zhang , Lian Duan , Yuewei Zhang 
Published: May 2023

Multiple resonance (MR) emitters are promising for the next-generation wide color gamut organic light-emitting diodes (OLEDs) with narrowband emissions; however, they still face intractable challenges such as concentration-induced emission quenching, exciton annihilation, and spectral broadening. In this concept, we focus on an advanced molecular design strategy called “sterically wrapping of MR fluorophores” to address the above issues. By isolating the MR emission core using bulky substituents, intermolecular interactions can be significantly suppressed to eliminate the formation of unfavorable species. Consequently, using the newly designed emitters, optimized MR-OLEDs can achieve high external quantum efficiencies of &gt;40% while maintaining extremely small full width at half maxima (FWHMs) of &lt;25 nm over a wide range of concentrations (1–20 wt%). This strategy may shed light on the design of efficient MR emitters, which provides more room for tuning the dopant concentrations under the premise of high-efficiencies and small FWHMs, accelerating the practical application of MR-OLEDs.
Comparison of prognosis between coronary computed tomography angiography versus invasive coronary angiography for stable coronary artery disease: a systematic review and meta-analysis
Authors: Xie Qingya , Zhou Lingling , Li Ying , Zhang Ruizhe , Wei Han , Ma Gaoxiang , Tang Yuping , Xiao Pingxi 
Published: May 2023

BackgroundThe impact of using invasive coronary angiography (ICA) or coronary computed tomography angiography (CCTA) as an initial examination on the incidence of major adverse cardiovascular events (MACEs) in patients with stable coronary artery disease and the occurrence of major operation-related complications is uncertain.ObjectiveThis study aimed to explore the effects of ICA vs. CCTA on MACEs, all-cause death, and major operation-related complications.MethodsA systematic search of electronic databases (PubMed and Embase) was conducted for randomized controlled trials and observational studies comparing MACEs between ICA and CCTA from January 2012 to May 2022. The primary outcome measure was analyzed using a random-effects model as a pooled odds ratio (OR). The main observations were MACEs, all-cause death, and major operation-related complications.ResultsA total of six studies, comprising 26,548 patients, met the inclusion criteria (ICA n = 8,472; CCTA n = 18,076). There were statistically significant differences between ICA and CCTA for MACE [OR 1.37; 95% confidence interval (CI), 1.06–1.77; p = 0.02], all-cause death (OR 1.56; 95% CI, 1.38–1.78; p &lt; 0.00001), and major operation-related complications (OR 2.10; 95% CI, 1.23–3.61; p = 0.007) among patients with stable coronary artery disease. Subgroup analysis demonstrated statistically significant results in the impact of ICA or CCTA on MACEs according to the length of follow-up. Compared to CCTA, ICA was related to a higher incidence of MACEs in the subgroup with a short follow-up (≤3 years) (OR 1.74; 95% CI, 1.54–1.96; p &lt; 0.00001).ConclusionsAmong patients with stable coronary artery disease, an initial examination with ICA was significantly associated with the risk of MACEs, all-cause death, and major procedure-related complications compared to CCTA in this meta-analysis.
Temporal changes in glucose metabolism reflect polarization in resident and monocyte-derived macrophages after myocardial infarction
Authors: Mouton Alan J. , Aitken Nikaela M. , Moak Sydney P. , do Carmo Jussara M. , da Silva Alexandre A. , Omoto Ana C. M. , Li Xuan , Wang Zhen , Schrimpe-Rutledge Alexandra C. , Codreanu Simona G. , Sherrod Stacy D. , McLean John A. , Hall John E. 
Published: May 2023

IntroductionMetabolic reprogramming from glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle and oxidative phosphorylation may mediate macrophage polarization from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype. We hypothesized that changes in cardiac macrophage glucose metabolism would reflect polarization status after myocardial infarction (MI), ranging from the early inflammatory phase to the later wound healing phase.MethodsMI was induced by permanent ligation of the left coronary artery in adult male C57BL/6J mice for 1 (D1), 3 (D3), or 7 (D7) days. Infarct macrophages were subjected to metabolic flux analysis or gene expression analysis. Monocyte versus resident cardiac macrophage metabolism was assessed using mice lacking the Ccr2 gene (CCR2 KO).ResultsBy flow cytometry and RT-PCR, D1 macrophages exhibited an M1 phenotype while D7 macrophages exhibited an M2 phenotype. Macrophage glycolysis (extracellular acidification rate) was increased at D1 and D3, returning to basal levels at D7. Glucose oxidation (oxygen consumption rate) was decreased at D3, returning to basal levels at D7. At D1, glycolytic genes were elevated (Gapdh, Ldha, Pkm2), while TCA cycle genes were elevated at D3 (Idh1 and Idh2) and D7 (Pdha1, Idh1/2, Sdha/b). Surprisingly, Slc2a1 and Hk1/2 were increased at D7, as well as pentose phosphate pathway (PPP) genes (G6pdx, G6pd2, Pgd, Rpia, Taldo1), indicating increased PPP activity. Macrophages from CCR2 KO mice showed decreased glycolysis and increased glucose oxidation at D3, and decreases in Ldha and Pkm2 expression. Administration of dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, robustly decreased pyruvate dehydrogenase phosphorylation in the non-infarcted remote zone, but did not affect macrophage phenotype or metabolism in the infarct zone.DiscussionOur results indicate that changes in glucose metabolism and the PPP underlie macrophage polarization following MI, and that metabolic reprogramming is a key feature of monocyte-derived but not resident macrophages.