bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protracted eclogite‐facies metamorphism of the Dulan area, North Qaidam ultrahigh‐pressure terrane: Insights on zircon growth during continental subduction and collision
Authors: Hernández‐Uribe David , Mattinson Chris G. , Regel Megan E. , Zhang Jianxin , Stubbs Katie A. , Kylander‐Clark Andrew R. C. 
Published: January 2023

AbstractContinental subduction and collision are recorded by ultrahigh‐pressure (UHP) terranes; UHP terranes that form at early stages of an orogeny tend to be small and experience short residence at eclogite‐facies depths, whereas terranes that form at mature stages of an orogeny tend to be larger and experience longer residence at these depths, but accurately determining eclogite‐facies residence time requires a large geochronologic dataset tied to metamorphic conditions (via trace elements and/or inclusions). In the Dulan area, North Qaidam UHP terrane, China, it remains unclear whether the terrane experienced a long residence at eclogite‐facies depths, marking the mature stage of an orogeny or two distinct (ultra)high pressure ([U]HP) events (with short residence times), interpreted as the transition from oceanic subduction to continental collision, where one (U)HP event is related to the former and second (U)HP event to the latter. To address this issue, we report new zircon U–Pb ages and trace‐element data from eclogite and host paragneiss from the Dulan area and show that this terrane records ~42 Myr of eclogite‐facies metamorphism at (U)HP conditions, similar to other large UHP terranes. Zircon from 11 eclogite and 2 gneiss samples yields weighted mean ages of 463–425 Ma, flat heavy rare earth element (HREE) patterns without negative Eu anomalies, and eclogitic mineral inclusions, indicating eclogite‐facies conditions. Paragneiss metamorphic ages overlap with ages from eclogite but are generally younger, suggesting that a lack of internally generated fluids may have inhibited zircon growth and/or recrystallization until early decompression and white mica consumption in felsic gneiss generated fluids; thus, we interpret that these felsic rocks record the later stages of continental collision. Dataset patterns from all new and previously published analyses for the Dulan area (34 eclogite and 14 gneiss) suggest that metamorphic zircon in eclogite records prograde, peak and possibly early retrograde conditions, in contrast to the prediction from mass balance models that metamorphic zircon should only grow during exhumation and cooling. We reconcile our observations with these model predictions by recognizing that differential solubility can lead to grain‐scale zircon growth or recrystallization over a large segment of the pressure–temperature (P–T) path even where zircon abundance decreases at the whole‐rock scale.
Enhancement of receptor‐mediated calcium responses by phenytoin through the suppression of calcium excretion in human gingival fibroblasts
Authors: Minowa Erika , Hayashi Yoshinobu , Goh Kenji , Ishida Narumi , Kurashige Yoshihito , Nezu Akihiro , Saitoh Masato , Tanimura Akihiko 
Published: January 2023

AbstractBackground and ObjectivesGingival overgrowth caused by phenytoin is proposed to be associated with Ca2+ signaling; however, the mechanisms that increase the intracellular Ca2+ concentration ([Ca2+]i) are controversial. The current study aimed to elucidate the mechanism underlying the phenytoin‐induced increase in [Ca2+]i in human gingival fibroblasts (HGFs).MethodsEffects of 100 μM phenytoin on [Ca2+]i in HGFs were examined at the single‐cell level using fluorescence images of fura‐2 captured by an imaging system consisting of an EM‐CCD camera coupled to an inverted fluorescence microscope at room temperature.ResultsExposure of HGFs to 100 μM phenytoin induced a transient increase in [Ca2+]i in the absence of extracellular Ca2+, indicating that the phenytoin‐induced increase in [Ca2+]i does not require an influx of extracellular Ca2+. In addition, phenytoin increased [Ca2+]i in HGFs depleted of intracellular Ca2+ stores by thapsigargin, indicating that neither Ca2+ release from stores nor inhibition of Ca2+ uptake is involved. Furthermore, the phenytoin‐induced [Ca2+]i elevation was reduced to 18.8% in the absence of extracellular Na+, and [Ca2+]i elevation upon removal of extracellular Na+ was reduced to 25.9% in the presence of phenytoin. These results imply that phenytoin increases [Ca2+]i of HGFs by suppressing the Na+/Ca2+ exchanger. Suppression of intracellular Ca2+ excretion is thought to enhance the Ca2+ responses induced by various stimuli. Analysis at the single‐cell level showed that stimulation with 1 μM ATP or 3 μM histamine increased [Ca2+]i in 20–50% of cells, and [Ca2+]i increased in many unresponsive cells in the presence of phenytoin.ConclusionOur findings demonstrate that phenytoin induced increase in [Ca2+]i by the inhibition of Ca2+ efflux in HGFs. It was also found that phenytoin strongly enhanced small Ca2+ responses induced by stimulation with a low concentration of ATP or histamine by inhibiting Ca2+ efflux. These findings suggest a possibility that phenytoin causes drug‐induced gingival overgrowth by interacting with inflammatory bioactive substances in the gingiva.
DDX3‐mediated miR‐34 expression inhibits autophagy and HBV replication in hepatic cells
Authors: Mishra Amit Kumar , Hossain Md Musa , Umar Mohd , Sata Teja Naveen , Yadav Ajay K. , Sah Amrendra Kumar , Ismail Md , Nayak Baibaswata , Shalimar  , Venugopal Senthil Kumar 
Published: January 2023

AbstractHBV entry to the host cells and its successful infection depends on its ability to modulate the host restriction factors. DEAD box RNA helicase, DDX3, is shown to inhibit HBV replication. However, the exact mechanism of inhibition still remains unclear. DDX3 is involved in multitude or RNA metabolism processes including biogenesis of miRNAs. In this study, we sought to determine the mechanism involved in DDX3‐mediated HBV inhibition. First, we observed that HBx protein of HBV downregulated DDX3 expression in HBV‐infected cells. Overexpression of DDX3 inhibited HBx, HBsAg and total viral load, while its knockdown reversed the result in Hep G2.2.15 cells. Expression of miR‐34 was downregulated in HBV‐infected cells. Overexpression of pHBV1.3 further confirmed that HBV downregulates miR‐34 expression. Consistent with the previous finding that DDX3 is involved in miRNA biogenesis, we observed that expression of miR‐34 positively corelated with DDX3 expression. miRNA target prediction tools showed that miR‐34 can target autophagy pathway which is hijacked by HBV for the benefit of its own replication. Indeed, transfection with miR‐34 oligos downregulated the expression of autophagy marker proteins in HBV‐expressing cells. Overexpression of DDX3 in HBV‐expressing cells, downregulated expression of autophagy proteins while silencing of DDX3 reversed the results. These results led us to conclude that DDX3 upregulates miR‐34 expression and thus inhibits autophagy in HBV‐expressing cells while HBx helps HBV evade DDX3‐mediated inhibition by downregulating DDX3 expression in HBV‐infected cells.
A novel DSPP frameshift mutation causing dentin dysplasia type 2 and disease management strategies
Authors: Yuan Minyan , Zheng Xueqing , Xue Yifan , He Zhenru , Song Guangtai , Song Yaling 
Published: January 2023

AbstractThe present study aims to investigate the mutation in a Chinese family with dentin dysplasia type II (DD‐II) and to summarize mutation hotspots, clinical manifestations, and disease management strategies. Phenotype analysis, clinical intervention, mutation screening, and cosegregation analysis within the enrolled family were performed. A summary of the reported mutations in the dentin phosphoprotein (DPP) region of dentin sialophosphoprotein (DSPP) was analyzed. Pathogenicity prediction analysis of the physical properties and function of DSPP variants was performed by bioinformatic processing. Clinical management strategies are discussed. A novel pathogenic mutation (c.2035delA) in the DPP region of DSPP was identified, which was cosegregated in the family. The immature permanent teeth of patients with DD‐II presented with X‐shaped root canal phenotypes. Most of the identified mutations for DD‐II were clustered in the DPP region between nucleotides 1686–2134. Points of differential diagnosis, clinical interventions, and management strategies are proposed. This study revealed a novel DSPP frameshift mutation and presented new clinical features of DD‐II. The locus involving nucleotides 1686–2134 of DSPP may represent a mutational hotspot for the disease. Appropriate management of DD‐II at different stages is important to avoid the development of secondary dental lesions.
Head‐and‐neck dermatofibrosarcoma protuberans: Survival analysis and Clinically relevant immunohistochemical indicators
Authors: Dai Zhenlin , He Youya , Zhang Xu , Tian Zhen , Zhu Guopei , Ren Zhenhu , Ye Lulu , Liu Zheqi , Ma Chunyue , Cao Wei , Ji Tong 
Published: January 2023

AbstractBackgroundHead and neck dermatofibrosarcoma protuberans (HNDFSP) is extremely rare and not entirely understood.ObjectiveTo investigate the clinicopathological features of HNDFSP and identify the expression of its clinically relevant indicators, with the expectation of improving the existing treatment strategies.MethodsA long‐term follow‐up of patients with HNDFSP who received treatment between 2000 and 2021 at Shanghai Ninth People's Hospital was conducted. The clinical, histological, and immunohistochemical data of the patients were retrieved and analyzed. The endpoint of the study was the incidence of significant disease‐related clinical events (recurrences or metastasis).ResultsA total of 49 patients with HNDFSP were included in the study, with males (92.7%) predominating than females (7.3%). Eighteen patients developed recurrent disease (36.8%) after surgery, and the median time of recurrence was 48 months (interquartile, 20–74 months). Metastasis occurred in two cases (4.1%). Two patients died during follow‐up, both with local recurrence, and one of them with intestinal metastasis. Post‐operation radiotherapy was administered to eight patients (16.3%) and the effect in local control was remarkable. Age, tumor size, and negative margins with sufficient safety width were the main independent factors affecting the disease‐free survival. Several potential targeted therapeutic indicators, including EZH2 (80.0%), EGFR (91.4%), PDGF (97.1%), PD‐L1 (77.1%), and VEGF (77.1%), were positively expressed in most tumor samples.ConclusionHNDFSP is rare, significantly challenging to control locally, and has a worse prognosis with current treatment strategies. Wide local excision and long‐term follow‐up are needed. Radiotherapy could improve the prognosis of patients with HNDFSP.
Impact of nonlocal dispersal and time periodicity on the global exponential stability of bistable traveling waves
Authors: Ma Manjun , Meng Wentao , Ou Chunhua 
Published: January 2023

AbstractGlobal exponential stability of bistable traveling wave solutions to a periodic Lotka–Volterra system with nonlocal dispersal is investigated. We first establish refined squeezing upper and lower solutions based on the properties of the bistable wavefront. This important squeezing technique has been successfully applied to study the exponential convergence of solutions.
Impacts of cognition of exercise on physical activity participation in hemodialysis patients
Authors: Huang Mei , Lv Aili , Yang Feng , Tang Yuning , Li Yang , Hua Yan , Gao Julin , Ni Chunping 
Published: January 2023

AbstractIntroductionPhysical inactivity is a strong predictor of mortality in hemodialysis patients. Although regular physical activity reduces mortality, patients remain inactive. Comparing the cognition of exercise in hemodialysis patients with different physical activity status could highlight domains where inactive people experience heightened barriers to physical activity. We therefore assessed patients' perceived benefits and barriers to exercise using a standardized way, thereby informing future exercise interventions to address these barriers experienced by inactive patients.MethodsESRD patients undergoing hemodialysis were recruited and asked to complete a human activity profile, wear a pedometer for seven consecutive days, and complete the Dialysis Patient‐perceived Exercise Benefits and Barriers Scale (DPEBBS). Binominal Logistic regression analysis was conducted to determine which benefits and barriers are associated with physical activity. This cross‐sectional observational study was registered as NCT05189795.ResultsA total of 505 patients completed the survey, most of whom were male (67.1%), with an average age of 49.69 ± 13.96 years. And 52.67–76.63% patients on HAP questionnaire were inactive. The co‐benefits in active patients were improving mood and prevention of muscle wasting but did not reach significance in physical activity level. Tiredness, muscle fatigue, and lack of knowledge of exercise were common barriers to patients, and all have a significant impact on a patient's physical activity level.ConclusionsFor inactive patients, exercise during hemodialysis can not only improve physical activity but also reduce family burden. And improving physical activity is a long‐term project that cannot be separated from the support of hemodialysis medical staff.
The full‐length Auxin Response Factor 8 isoform ARF8.1 controls pollen cell wall formation and directly regulates TDF1, AMS and MS188 expression
Authors: Ghelli Roberta , Brunetti Patrizia , Marzi Davide , Cecchetti Valentina , Costantini Marco , Lanzoni‐Rossi Mônica , Scaglia Linhares Francisco , Costantino Paolo , Cardarelli Maura 
Published: January 2023

SUMMARYAuxin Response Factor 8 plays a key role in late stamen development: its splice variants ARF8.4 and ARF8.2 control stamen elongation and anther dehiscence. Here, we characterized the role of ARF8 isoforms in pollen fertility. By phenotypic and ultrastructural analysis of arf8‐7 mutant stamens, we found defects in pollen germination and viability caused by alterations in exine structure and pollen coat deposition. Furthermore, tapetum degeneration, a prerequisite for proper pollen wall formation, is delayed in arf8‐7 anthers. In agreement, the genes encoding the transcription factors TDF1, AMS, MS188 and MS1, required for exine and pollen coat formation, and tapetum development, are downregulated in arf8‐7 stamens. Consistently, the sporopollenin content is decreased, and the expression of sporopollenin synthesis/transport and pollen coat protein biosynthetic genes, regulated by AMS and MS188, is reduced. Inducible expression of the full‐length isoform ARF8.1 in arf8‐7 inflorescences complements the pollen (and tapetum) phenotype and restores the expression of the above transcription factors. Chromatin immunoprecipitation‐quantitative polymerase chain reaction assay revealed that ARF8.1 directly targets the promoters of TDF1, AMS and MS188. In conclusion, the ARF8.1 isoform controls pollen and tapetum development acting directly on the expression of TDF1, AMS and MS188, which belong to the pollen/tapetum genetic pathway.
Mechanical Response of Stress Wave Attenuator With Layered Structure Under Impact Load: Experimental and Numerical Studies
Authors: Yang Zhenglong , Peng Jianming , Ge Dong , Li Yanliang , Li Jiming , Liu Pengcheng 
Published: January 2023

Abstract
The fluidic down-the-hole (DTH) hammer drilling is generally regarded as one of the best means for hot dry rock (HDR) drilling. The fluid oscillator, as the core part of the fluidic DTH hammer, is prone to fracture when subjected to impact loads due to its brittle characteristics. Therefore, a steel-layered structure with different contact areas is developed as a stress wave attenuator to protect the fluid oscillator for the DTH hammer under high-temperature drilling conditions. In this paper, the stress wave attenuation performance with different steel-layered structures is analyzed based on the split Hopkinson pressure bar (SHPB) technique. The effects of contact area ratio, the orientation of contact surfaces, and number of layers on the stress wave attenuation are investigated by numerical simulations and laboratory tests. It is found that the attenuation ratios in stress amplitude and impact energy gradually increased with the increase of the contact area ratio. Besides, the orientation of contact surfaces has a significant influence on the attenuation effect. For the layered structure with a two-layer object part, the maximum attenuation ratios of stress amplitude and impact energy are 62.4% and 79.6%, respectively, when the included angle between the two convex structures is increased to 90 deg. Additionally, the attenuation ratio of the layered structure can be improved by increasing the number of layers. The results demonstrate that the stress wave attenuator with layered structures has great potential for brittle materials protection against impact loads.
Design Considerations and Robustness to Parameter Uncertainty in Wire-Wrapped Cam Mechanisms
Authors: Johnston Garrison L. H. , Orekhov Andrew L. , Simaan Nabil 
Published: January 2023

Abstract
Collaborative robots must simultaneously be safe enough to operate in close proximity to human operators and powerful enough to assist users in industrial tasks such as lifting heavy equipment. The requirement for safety necessitates that collaborative robots are designed with low-powered actuators. However, some industrial tasks may require the robot to have high payload capacity and/or long reach. For collaborative robot designs to be successful, they must find ways of addressing these conflicting design requirements. One promising strategy for navigating this tradeoff is through the use of static balancing mechanisms to offset the robot’s self-weight, thus enabling the selection of low-powered actuators. In this paper, we introduce a novel, two degrees-of-freedom static balancing mechanism based on spring-loaded, wire-wrapped cams. We also present an optimization-based cam design method that guarantees the cams stay convex, ensures the springs stay below their extensions limits, and minimizes sensitivity to unmodeled deviations from the nominal spring constant. Additionally, we present a model of the effect of friction between the wire and the cam. Lastly, we show experimentally that the torque generated by the cam mechanism matches the torque predicted in our modeling approach. Our results also suggest that the effects of wire-cam friction are significant for non-circular cams.
Theoretical Development in the Viscosity of Ferrofluid
Authors: Bhandari Anupam 
Published: January 2023

AbstractThe viscosity of ferrofluid has a vital role in liquid sealing of the hard disk drives, biomedical applications as drug delivery, hyperthermia, and magnetic resonance imaging. The theoretical expressions for ferrofluid viscosity and its limitation are presented in detail in this article. A qualitative comparison of the theoretical and experimental viscosity results is also shown. In the absence of a magnetic field, the viscosity of ferrofluid depends on the volume concentration of magnetic nanoparticles, including surfactant layers. However, the viscosity of ferrofluid due to stationary magnetic field depends on the angle between the applied magnetic field and vorticity in the flow. If this angle is 90 deg, then there is a maximum increase in the viscosity. When field frequency matches with the relaxation time, known as resonance condition, then there is no impact of an alternating magnetic field in the viscosity of ferrofluid. If the frequency of an alternating magnetic field is less than resonance frequency, then an alternating magnetic field increases the viscosity of ferrofluid. For diluted ferrofluid, present theoretical results of viscosity have good agreement with the experimental data.
Effects of Axial Clearance on Surface Initiated Flaking in Tapered Roller Bearings
Authors: Takahashi Ken , Nagatomo Takafumi 
Published: January 2023

Abstract
The calculating method for fatigue life of rolling bearings is based on the theory of Lundberg and Palmgren. The rated life is determined from the ratio of the dynamic load rating of the bearing to the dynamic equivalent load. However, in actual applications, flaking damage may occur earlier than this rated life. For example, surface initiated flaking may occur due to contamination in the lubricant. In addition, differences in the internal clearance of bearings are also thought to influence the occurrence of surface initiated flaking. This study aims to investigate the effect of different internal clearance on surface initiated flaking in tapered roller bearings. First, rotating tests were conducted on combination tapered roller bearings with dented raceways under several axial clearances different from the standard condition. Second, the surface profiles of the bearings before and after the tests were compared to investigate the relationship between the distribution of flaking area and the axial clearance. Furthermore, the effect of axial clearance on the surface initiated flaking life was clarified from the comparison between the results of the rotating tests. Finally, the theoretical and experimental lives were compared. As a result, it has been found that when the axial clearance is excessively large, the distribution of flaking is biased toward the large diameter side of the outer raceway. In addition, it has been demonstrated that the bearing life is substantially affected by the axial clearance, and that the bearing life shortens as the axial clearance increases.
Dynamic semiconductor-electrolyte interface for sustainable solar water splitting over 600 hours under neutral conditions
Authors: Gao Rui-Ting , Nguyen Nhat Truong , Nakajima Tomohiko , He Jinlu , Liu Xianhu , Zhang Xueyuan , Wang Lei , Wu Limin 
Published: January 2023

Photoelectrochemical (PEC) water splitting that functions in pH-neutral electrolyte attracts increasing attention to energy demand sustainability. Here, we propose a strategy to in situ form a NiB layer by tuning the composition of the neutral electrolyte with the additions of nickel and borate species, which improves the PEC performance of the BiVO
4
photoanode. The NiB/BiVO
4
exhibits a photocurrent density of 6.0 mA cm
−2
at 1.23 V
RHE
with an onset potential of 0.2 V
RHE
under 1 sun illumination. The photoanode displays a photostability of over 600 hours in a neutral electrolyte. The additive of Ni
2+
in the electrolyte, which efficiently inhibits the dissolution of NiB, can accelerate the photogenerated charge transfer and enhance the water oxidation kinetics. The borate species with B─O bonds act as a promoter of catalyst activity by accelerating proton-coupled electron transfer. The synergy effect of both species suppresses the surface charge recombination and inhibits the photocorrosion of BiVO
4
.