bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large‐gap peripheral nerve repair using xenogeneic transplants in rhesus macaques
Authors: Holzer Paul , Chang Elizabeth J. , Rogers Kaitlyn , Tarlton Jamie , Lu Diana , Gillespie Natasha , Adkins Jon , Metea Monica , LaRochelle Alan , Wicks Joan , Onel Buket , Gullans Steve , Doloff Joshua C. , Scobie Linda , Cetrulo Curtis L. , Monroy Rod 
Published: January 2023

AbstractSurgical intervention is required to successfully treat severe, large‐gap (≥4 cm) peripheral nerve injuries. However, all existing treatments have shortcomings and an alternative to the use of autologous nerves is needed. Human and porcine nerves are physiologically similar, with comparable dimensions and architecture, presence and distribution of Schwann cells, and conserved features of the extracellular matrix (ECM). We report the repair of fully transected radial nerves in 10 Rhesus Macaques using viable, whole sciatic nerve from genetically engineered (GalT‐KO), designated pathogen free (DPF) porcine donors. This resulted in the regeneration of the transected nerve, and importantly, recovery of wrist extension function, distal muscle reinnervation, and recovery of nerve conduction velocities and compound muscle action potentials similar to autologous controls. We also demonstrate the absence of immune rejection, systemic porcine cell migration, and detectable residual porcine material. Our preliminary findings support the safety and efficacy of viable porcine nerve transplants, suggest the interchangeable therapeutic use of cross‐species cells, and highlight the broader clinical potential of xenotransplantation.
Differential graded Koszul duality: An introductory survey
Authors: Positselski Leonid 
Published: January 2023

AbstractThis is an overview on derived nonhomogeneous Koszul duality over a field, mostly based on the author's memoir L. Positselski, Memoirs of the American Math. Society 212 (2011), no. 996, vi+133. The paper is intended to serve as a pedagogical introduction and a summary of the covariant duality between DG‐algebras and curved DG‐coalgebras, as well as the triality between DG‐modules, CDG‐comodules, and CDG‐contramodules. Some personal reminiscences are included as a part of historical discussion.
Global Product Design Platforming: A Comparison of Two Equilibrium Solution Methods
Authors: Case Sarah , Michalek Jeremy J. , Whitefoot Kate S. 
Published: January 2023

AbstractGlobal product platforms can reduce production costs through economies of scale and learning but may decrease revenues by restricting the ability to customize for each market. We model the global platforming problem as a Nash equilibrium among oligopolistic competing firms, each maximizing its profit across markets with respect to its pricing, design, and platforming decisions. We develop and compare two methods to identify Nash equilibria: (1) a sequential iterative optimization (SIO) algorithm, in which each firm solves a mixed-integer nonlinear programming problem globally, with firms iterating until convergence; and (2) a mathematical program with equilibrium constraints (MPEC) that solves the Karush Kuhn Tucker conditions for all firms simultaneously. The algorithms’ performance and results are compared in a case study of plug-in hybrid electric vehicles where firms choose optimal battery capacity and whether to platform or differentiate battery capacity across the US and Chinese markets. We examine a variety of scenarios for (1) learning rate and (2) consumer willingness to pay (WTP) for range in each market. For the case of two firms, both approaches find the Nash equilibrium in all scenarios. On average, the SIO approach solves 200 times faster than the MPEC approach, and the MPEC approach is more sensitive to the starting point. Results show that the optimum for each firm is to platform when learning rates are high or the difference between consumer willingness to pay for range in each market is relatively small. Otherwise, the PHEVs are differentiated with low-range for China and high-range for the US.
The Stryd Foot Pod Is a Valid Measure of Stepping Cadence During Treadmill Walking and Running
Authors: Shivgulam Madeline E. , Petterson Jennifer L. , Pellerine Liam P. , Kimmerly Derek S. , O’Brien Myles W. 
Published: January 2023

Stepping cadence is an important determinant of activity intensity, with faster stepping associated with the most health benefits. The Stryd monitor provides real-time feedback on stepping cadence. The limited existing literature has neither validated the Stryd across slow walking to fast running speeds nor strictly followed statistical guidelines for monitor validation studies. We assessed the criterion validity of the Stryd monitor to detect stepping cadence across multiple walking and jogging/running speeds. It was hypothesized that the Stryd monitor would be an accurate measure of stepping cadence across all measured speeds. Forty-six participants (23 ± 5 years, 26 females) wore the Stryd monitor on their shoelaces during a 10-stage progressive treadmill walking (Speeds 1–5) and jogging/running (Speeds 6–10) protocol (criterion: manually counted video-recorded cadence; total stages: 438). Standardized guidelines for physical activity monitor statistical analyses were followed. A two-way repeated-measure analysis of variance revealed the Stryd monitor recorded a slightly higher cadence (<1 steps/min difference, all p < .001) at 2 miles/hr (92.1 ± 6.2 steps/min vs. 91.5 ± 6.4 steps/min, p < .001), 2.5 miles/hr (101.3 ± 6.1 steps/min vs. 100.7 ± 6.4 steps/min), and 3.5 miles/hr (117.4 ± 5.9 steps/min vs. 117.0 ± 6.0 steps/min). However, equivalence testing demonstrated high equivalence of the Stryd and manually counted cadence (equivalence zone required: ≤± 2.6%) across all speeds. The Stryd activity monitor is a valid measure of stepping cadence across walking, jogging, and running speeds. By providing real-time cadence feedback, the Stryd monitor has strong potential to help guide the general public monitor their stepping intensity to promote more habitual activity at faster cadences.
Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model
Authors: Mavaddat Nasim , Ficorella Lorenzo , Carver Tim , Lee Andrew , Cunningham Alex P. , Lush Michael , Dennis Joe , Tischkowitz Marc , Downes Kate , Hu Donglei , Hahnen Eric , Schmutzler Rita K. , Stockley Tracy L. , Downs Gregory S. , Zhang Tong , Chiarelli Anna M. , Bojesen Stig E. , Liu Cong , Chung Wendy K. , Pardo Monica , Feliubadaló Lidia , Balmaña Judith , Simard Jacques , Antoniou Antonis C. , Easton Douglas F. 
Published: January 2023

ABSTRACT

Background:
The multifactorial risk prediction model BOADICEA enables identification of women at higher or lower risk of developing breast cancer. BOADICEA models genetic susceptibility in terms of the effects of rare variants in breast cancer susceptibility genes and a polygenic component, decomposed into an unmeasured and a measured component - the polygenic risk score (PRS). The current version was developed using a 313 SNP PRS. Here, we evaluated approaches to incorporating this PRS and alternative PRS in BOADICEA.

Methods:
The mean, SD, and proportion of the overall polygenic component explained by the PRS (α2) need to be estimated. α was estimated using logistic regression, where the age-specific log-OR is constrained to be a function of the age-dependent polygenic relative risk in BOADICEA; and using a retrospective likelihood (RL) approach that models, in addition, the unmeasured polygenic component.

Results:
Parameters were computed for 11 PRS, including 6 variations of the 313 SNP PRS used in clinical trials and implementation studies. The logistic regression approach underestimates α, as compared with the RL estimates. The RL α estimates were very close to those obtained by assuming proportionality to the OR per 1 SD, with the constant of proportionality estimated using the 313 SNP PRS. Small variations in the SNPs included in the PRS can lead to large differences in the mean.

Conclusions:
BOADICEA can be readily adapted to different PRS in a manner that maintains consistency of the model.

Impact:
The methods described facilitate comprehensive breast cancer risk assessment.
Stability of the Fecal and Oral Microbiome over 2 Years at −80°C for Multiple Collection Methods
Authors: Zouiouich Semi , Byrd Doratha A. , Hua Xing , Karwa Smriti , Wan Yunhu , Shi Jianxin , Humphrey Gregory C. , Ackermann Gail L. , Knight Rob , Abnet Christian C. , Vogtmann Emily , Sinha Rashmi 
Published: January 2023

AbstractBackground:In prospective cohorts, biological samples are generally stored over long periods before an adequate number of cases have accrued. We investigated the impact of sample storage at −80°C for 2 years on the stability of the V4 region of the 16S rRNA gene across seven different collection methods (i.e., no additive, 95% ethanol, RNAlater stabilization solution, fecal occult blood test cards, and fecal immunochemical test tubes for feces; OMNIgene ORAL tubes and Scope mouthwash for saliva) among 51 healthy volunteers.Methods:Intraclass correlation coefficients (ICC) were calculated for the relative abundance of the top three phyla, the 20 most abundant genera, three alpha-diversity metrics, and the first principal coordinates of three beta-diversity matrices.Results:The subject variability was much higher than the variability introduced by the sample collection type, and storage time. For fecal samples, microbial stability over 2 years was high across collection methods (range, ICCs = 0.70–0.99), except for the samples collected with no additive (range, ICCs = 0.23–0.83). For oral samples, most microbiome diversity measures were stable over time with ICCs above 0.74; however, ICCs for the samples collected with Scope mouthwash were lower for two alpha-diversity measures, Faith's phylogenetic diversity (0.23) and the observed number of operational taxonomic units (0.23).Conclusions:Fecal and oral samples in most used collection methods are stable for microbiome analyses after 2 years at −80°C, except for fecal samples with no additive.Impact:This study provides evidence that samples stored for an extended period from prospective studies are useful for microbiome analyses.
Liquid Biopsy of Cerebrospinal Fluid Enables Selective Profiling of Glioma Molecular Subtypes at First Clinical Presentation
Authors: Orzan Francesca , De Bacco Francesca , Lazzarini Elisabetta , Crisafulli Giovanni , Gasparini Alessandra , Dipasquale Angelo , Barault Ludovic , Macagno Marco , Persico Pasquale , Pessina Federico , Bono Beatrice , Giordano Laura , Zeppa Pietro , Melcarne Antonio , Cassoni Paola , Garbossa Diego , Santoro Armando , Comoglio Paolo M. , Indraccolo Stefano , Simonelli Matteo , Boccaccio Carla 
Published: January 2023

AbstractPurpose:Current glioma diagnostic guidelines call for molecular profiling to stratify patients into prognostic and treatment subgroups. In case the tumor tissue is inaccessible, cerebrospinal fluid (CSF) has been proposed as a reliable tumor DNA source for liquid biopsy. We prospectively investigated the use of CSF for molecular characterization of newly diagnosed gliomas.Experimental Design:We recruited two cohorts of newly diagnosed patients with glioma, one (n = 45) providing CSF collected in proximity of the tumor, the other (n = 39) CSF collected by lumbar puncture (LP). Both cohorts provided tumor tissues by surgery concomitant with CSF sampling. DNA samples retrieved from CSF and matched tumors were systematically characterized and compared by comprehensive (NGS, next-generation sequencing) or targeted (ddPCR, droplet digital PCR) methodologies. Conventional and molecular diagnosis outcomes were compared.Results:We report that tumor DNA is abundant in CSF close to the tumor, but scanty and mostly below NGS sensitivity threshold in CSF from LP. Indeed, tumor DNA is mostly released by cells invading liquoral spaces, generating a gradient that attenuates by departing from the tumor. Nevertheless, in &gt;60% of LP CSF samples, tumor DNA is sufficient to assess a selected panel of genetic alterations (IDH and TERT promoter mutations, EGFR amplification, CDKN2A/B deletion: ITEC protocol) and MGMT methylation that, combined with imaging, enable tissue-agnostic identification of main glioma molecular subtypes.Conclusions:This study shows potentialities and limitations of CSF liquid biopsy in achieving molecular characterization of gliomas at first clinical presentation and proposes a protocol to maximize diagnostic information retrievable from CSF DNA.
Blue-yellow emissive LaAlO<sub>3</sub>:Dy<sup>3+</sup> phosphor for high bright white light-emitting diodes
Authors: Tung Ha Thanh , Dang Huu Phuc 
Published: January 2023

LaAlO3:Dy3+ (LAO:Dy3+) with blue-yellow emission for brilliant white light of light-emitting diodes (LEDs) was prepared using gel-combustion process. The chemical content of the created material was confirmed using energy dispersive X-ray analysis (EDX). The transmission electron microscopy was used to examine the phosphor crystal size and morphology. The luminescence analysis showed that LAO:Dy3+ phosphors exhibited peaks at 482 nm (blue) and 574 nm (yellow), attributed to the transitions 4F 9/2à6H 15/2 and 4F 9/2à6H 13/2, respectively. The investigating of correlated color temperature (CCT) and Commission International de L'Eclairage (CIE) described that the phosphor LAO:Dy3+ helped to attained good CCT coordination and bright cool-white emission under ultraviolet (UV) stimulation. However, when using in white LED fabrication, the concentration of LAO:Dy3+ should be modified to fulfill the need from manufactures. According to results from this work, the white light luminescence intensity and color rendering performance may be reduced if the LAO:Dy3+ is high (10%) because of too much scattering. On the other hand, such scattering improvements offered by LAO:Dy3+ phosphor is beneficial to reduce the color deviance for better color uniformity of light.
Temporal Trends in In-Hospital Outcomes Following Unprotected Left-Main Percutaneous Coronary Intervention: An Analysis of 14 522 Cases From British Cardiovascular Intervention Society Database 2009 to 2017
Authors: Kinnaird Tim , Gallagher Sean , Farooq Vasim , Protty Majd , Back Liam , Devlin Peadar , Anderson Richard , Sharp Andrew , Ludman Peter , Copt Samuel , Mamas Mamas A. , Curzen Nick 
Published: January 2023

Background:Percutaneous coronary intervention (PCI) is increasingly used as a treatment option for unprotected left main stem artery (unprotected left main stem percutaneous intervention) disease. However, whether patient outcomes have improved over time is uncertain.Methods:Using the United Kingdom national PCI database, we studied all patients undergoing unprotected left main stem percutaneous intervention between 2009 and 2017. We excluded patients who presented with ST-segment–elevation, cardiogenic shock, and with an emergency indication for PCI.Results:Between 2009 and 2017, in the study-indicated population, 14 522 unprotected left main stem percutaneous intervention procedures were performed. Significant temporal changes in baseline demographics were observed with increasing patient age and comorbid burden. Procedural complexity increased over time, with the number of vessels treated, bifurcation PCI, number of stents used, and use of intravascular imaging and rotational atherectomy increased significantly through the study period. After adjustment for baseline differences, there were significant temporal reductions in the occurrence of peri-procedural myocardial infarction (P<0.001 for trend), in-hospital major adverse cardiac or cerebrovascular events (P<0.001 for trend), and acute procedural complications (P<0.001 for trend). In multivariable analysis examining the associates of in-hospital major adverse cardiac or cerebrovascular events, while age per year (odds ratio, 1.02 [95% CIs, 1.01–1.03]), female sex (odds ratio, 1.47 [1.19–1.82]), 3 or more stents (odds ratio, 1.67 [05% [1.02–2.67]), and patient comorbidity were associated with higher rates of in-hospital major adverse cardiac or cerebrovascular events, by contrast use of intravascular imaging (odds ratio, 0.56 [0.45–0.70]), and year of PCI (odds ratio, 0.63 [0.46–0.87]) were associated with lower rates of in-hospital major adverse cardiac or cerebrovascular events.Conclusions:Despite trends for increased patient and procedural complexity, in-hospital patient outcomes have improved after unprotected left main stem percutaneous intervention over time.
In-Habitant: An Inquiry into a Non-Dualistic Duality of Human and Nonhuman
Authors: Tasa Umut 
Published: January 2023

Abstract
In-Habitant is an art and life project based on artist Umut Tasa’s decadelong encounters with urban wildlife. It is a quest to utilize art as a research method to contemplate her memories, nature discoveries, audiovisual records, and archive of haiku and prose through a body of artworks. These artworks bring together the corporeality of nonhumans with their digital re-presentation and literary text with creative coding. The author inquires into dualistic and nondualistic ontological approaches to human-nonhuman relations in urban settings.
Neither Fish, Nor Fowl
Authors: Linderfalk Ulf 
Published: January 2023

Abstract
International lawyers ascribe to the lex specialis principle three distinctly different meanings. Thus, lex specialis is referred to, first, as a norm designed to resolve conflicts between entire categories of norms; secondly, as a norm designed to resolve conflicts on a case-by-case basis; and, thirdly, as a rule of interpretation designed to avoid the occurrence of normative conflicts, rather than to resolve them. Scholars have attempted to explain this divergent use of legal language. In so doing, they have consistently had their focus on the different mind-sets or inclinations of lawyers active in different branches of international law. Symptomatic is Marko Milanović, who pictured the divergent use of lex specialis as a reflection of a debate waged between “human rights enthusiasts” and “human rights sceptics”. This article approaches the issue at a different level of abstraction. As it argues, the divergent use of lex specialis is the result of users’ different conceptions of an international legal system. Thus, lawyers conceive differently of the lex specialis principle, depending on whether they take the position of a legal positivist, a legal idealist or a legal realist. In no case are lawyers equipped to conceive of this principle in all of its three senses.
Serbo-Croatian as a Language of Sephardic Literature: The Cases of Isak Samokovlija and Jacques Confino
Authors: Oparnica Željka 
Published: January 2023

Abstract
The early twentieth century saw a rise in Jewish writers in what is traditionally considered non-Jewish languages in the Balkans like in the rest of Europe. In light of this phenomenon’s significance, we pose the question why and how Serbo-Croatian became a language of Sephardic literature. The article questions the accepted narrative of ‘linguistic acculturation’ of Sephardic Jews in the Balkans and unearths the complex cultural, but also political background of this Jewish phenomenon using the examples of two prolific, recognized, and celebrated writers of Sephardic background, Isak Samokovlija and Jacques Confino. Through historicization of Sephardic multilingualism in Serbia and in Bosnia and Herzegovina from the 1890s to the 1920s, it argues that the adoption of Serbo-Croatian was motivated equally, if not dominantly, by Jewish political aims in the region rather than the pressures of emancipation only. Samokovlija and Confino’s biographies and cultural choices, therefore, illuminate an unlikely Sephardic history.
(Un)spoken Histories: The Second World War and Yugoslav Jewish Women
Authors: Taczyńska Katarzyna 
Published: January 2023

Abstract
The article discusses the experiences of Yugoslav Jewish women during the Second World War and the Holocaust. It presents little known texts (fictional, paraliterary and documentary works) written by Jewish women (Hilda Dajč, Elvira Kohn, Lea Abinun, Ženi Lebl, and Gina Camhy), one non-Jewish woman (Milojka Mezorana), and one Jewish man (Đorđe Lebović), during or after the Second World War. The main aim of the analysis is to draw attention to the specificity of Jewish women’s narratives in the (post-)Yugoslav cultural space, the contextual framework in which they function, and the risk of their mis- or overinterpretation. The analysis presents also the spectrum of possible readings of texts created during or thematizing the Second World War which are either written by or refer to Jewish women—a group which remained unduly marginalized in the official memory of the Second World War and its aftermath.
Updating the taxonomy, phylogeny and biogeography of the aberrant genus Coenosopsia Malloch (Diptera: Anthomyiidae)
Authors: Gomes Lucas Roberto Pereira , de Carvalho Claudio José Barros 
Published: January 2023

Abstract
Coenosopsia Malloch has eight known species distributed from southern North America to south-eastern South America. The species of the genus are morphologically very homogeneous, and major differences remain in male terminalia. Remarkably, two of the main diagnostic characteristics of Anthomyiidae are absent in this genus: the setulae on the ventral surface of the scutellum and vein A1 reaching the wing margin. Some studies have attempted to propose biogeographical narratives, primarily for the Neotropical distribution of the genus. Herein, we describe three new species of Coenosopsia from north-eastern Brazil (Coenosopsia limeirai sp. nov.), southern Brazil (Coenosopsia ribeiroi sp. nov.), and central Mexico (Coenosopsia azteca sp. nov.) and present an identification key. In addition, we present an updated phylogenetic analysis based on morphological evidence, which recovered Coenosopsia as monophyletic based on five synapomorphies and four homoplasies. We also presented the first biogeographical hypothesis of Coenosopsia based on biogeographic methods (ancestral reconstruction character and S-DIVA analyses), which indicated a Mesoamerican origin of the genus.
Mark the Words: Early Music’s Representation in Writing
Authors: Blankenborg Ronald 
Published: January 2023

Abstract
This paper argues for the interpretation of the words on Basel BS 415 as the markers not only of the song’s content, but equally of its musical notation. Predating such notation, the inscribed syllables reflect language’s priority over music, as opposed to the later reversal of these priorities. On Basel BS 415, written words’ orthography sufficed as an indication of the syllables’ prosodic qualities that enabled musical accompaniment to follow the lead of verbal rhythm and melody. As later reform likely championed the opposite, orthography gradually gave way to specialised musical signs and notation to account for the music that was to be the frame within which sung language was to be fitted. Basel BS 415, I will argue, conforms to the practice of representing song through sung words as evidenced in metrical inscriptions of the archaic period.