bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aptamer proteomics of serum exosomes from patients with Primary Raynaud’s and patients with Raynaud’s at risk of evolving into Systemic Sclerosis
Authors: Piera-Velazquez Sonsoles , Dillon Simon T. , Gu Xuesong , Libermann Towia A. , Jimenez Sergio A. 
Published: December 2022

Background
A major unmet need for Systemic Sclerosis (SSc) clinical management is the lack of biomarkers for the early diagnosis of patients with Raynaud’s Phenomenon at high risk of evolving into SSc.

Objective
To identify proteins contained within serum exosomes employing an aptamer proteomic analysis that may serve to reveal patients with Raynaud’s Phenomenon at risk of developing SSc.

Methods
Exosomes were isolated from serum samples from patients with Primary Raynaud’s Phenomenon and from patients with Raynaud’s Phenomenon harbouring serum antinuclear antibodies (ANA) who may be at high risk of evolving into SSc. The expression of 1,305 proteins was quantified using SOMAscan aptamer proteomics, and associations of the differentially elevated or reduced proteins with the clinical subsets of Raynaud’s Phenomenon were assessed.

Results
Twenty one differentially elevated and one differentially reduced (absolute fold change >|1.3|) proteins were identified. Principal component analysis using these 22 most differentially expressed proteins resulted in excellent separation of the two Raynaud’s Phenomenon clinical subsets. Remarkably, the most differentially elevated proteins are involved in enhanced inflammatory responses, immune cell activation and cell migration, and abnormal vascular functions.

Conclusion
Aptamer proteomic analysis of circulating exosomes identified differentially elevated or reduced proteins between Raynaud’s Phenomenon at high risk of evolving into SSc and Primary Raynaud’s Phenomenon patients. Some of these proteins are involved in relevant biological pathways that may play a role in SSc pathogenesis including enhanced inflammatory responses, immune cell activation, and endothelial cell and vascular abnormalities.
Ameliorating creativity in engineering education: Educator perspective
Authors: Tekmen-Araci Yasemin , Kuys Blair 
Published: December 2022

Engineering students need creative thinking skills to achieve innovation. This study focuses on ameliorating the creative process in engineering design units with the purpose of getting more creative and innovative engineering design solutions from students and better preparing them for industry and real-life conditions. It is suggested that engineering should use design pedagogy as a model for ameliorating creativity. The research is carried out using qualitative investigation. The study used triangulation to collect data about engineering educators’ approach, understanding and beliefs about creativity using observational research, a survey and in-depth interviews both with students and with educators. The study used an interpretive approach for data analysis by following the levels of understanding in an organizational culture. Three main results drawn from this work are as follows: (1) Engineering educators should understand the practice of creativity in an educational context. (2) Engineering educators need to value creativity as an important part of engineering design. (3) The discipline needs to value creativity as a core part of the curriculum.
The findings suggests that enriching creativity in engineering education is not feasible until engineering instructors comprehend and embrace the use of creativity in the classroom. This article specifically explores ways of integrating creativity in engineering design processes that took place in a mechanical engineering undergraduate programme – with an expectation that the research can be used as an exemplar for other engineering disciplines to learn from. This study is an important step, with a holistic approach, in suggesting creativity and creative thinking be inherent and an integral part of every engineering curriculum.
Policyjne determinanty w profilowaniu wolnych zawodów
Authors: Kocowski Tadeusz , Małecki Witold 
Published: December 2022

The possibility of taking up and practising liberal professions is generally dependent on the possession of professional qualiﬁcations, set out in law. The need to obtain certain qualiﬁcations often stems from the necessity to protect such goods as life, health and property. These might be referred to as ‘police goods’. They are existential for the functioning of the state, society and individuals, and are protected within the most important and most signiﬁcant function of the state, which is the police. One of the areas of the police is the economic police, related to the protection of police goods against threats that may arise as a result of economic activity.Among the liberal professions there are those for which the requirements of obtaining certain qualiﬁcations result from the need to protect life and health. These are, in the ﬁrst place, professions whose performance on the basis of appropriate qualiﬁcations guarantees a high level of protection of the life and health of the direct recipients of services provided by a person performing a liberal profession. This applies to the medical professions – doctors, dentists, nurses, midwifes, pharmacists and physiotherapists. Secondly, it is necessary to mention the professions the performance of which on the basis of appropriate qualiﬁcations guarantees a high level of protection of life and health of the undetermined group of persons. These professions include that of the architect and civil engineer.A disputable issue is whether professions whose representatives are to protect their clients against unfavourable or unlawful disposal of their own property can be considered liberal professions, where the requirement to obtain certain qualiﬁcations results from the need to protect police states and goods. These are legal professions, as well as the professions of investment advisor and property appraiser.
Implicación del estrés oxidativo en las enfermedades neurodegenerativas y posibles terapias antioxidantes
Authors: Sienes Bailo Paula , Llorente Martín Elena , Calmarza Pilar , Montolio Breva Silvia , Bravo Gómez Adrián , Pozo Giráldez Adela , Sánchez-Pascuala Callau Joan José , Vaquer Santamaría Juana Maria , Dayaldasani Khialani Anita , Cerdá Micó Concepción , Camps Andreu Jordi , Sáez Tormo Guillermo , Fort Gallifa Isabel 
Published: December 2022

Resumen

Objetivos
El sistema nervioso central es fundamental en el control de la homeostasis y mantenimiento de las funciones fisiológicas del organismo. Sin embargo, sus características bioquímicas hacen que sea especialmente vulnerable al daño oxidativo, lo que compromete su correcto funcionamiento, desencadenando neurodegeneración y muerte neuronal.

Contenido
El estrés oxidativo desempeña un papel importante en la fisiopatología de las enfermedades neurodegenerativas dado que participa en multitud de mecanismos que inducen oxidación de ácidos nucleicos, proteínas y lípidos, contribuyendo con ello, al daño cerebral progresivo. Entre estos mecanismos se encuentran la disfunción mitocondrial, generación excesiva de especies reactivas de oxígeno y nitrógeno, déficit de defensas antioxidantes, oligomerización de proteínas, producción de citoquinas y respuesta inflamatoria, alteración de la barrera hematoencefálica o disfunción del proteasoma. Todas estas disfunciones se han visto implicadas en la patogénesis de diversas enfermedades neurodegenerativas, como la enfermedad de Parkinson, Alzheimer, Huntington o esclerosis lateral amiotrófica.

Resumen y perspectivas
Aunque actualmente no existen tratamientos curativos, las investigaciones se han dirigido a la búsqueda de terapias que permitan reducir el daño secundario al estrés oxidativo y ralentizar la evolución de la enfermedad. Es aquí donde las investigaciones sobre el efecto de las terapias antioxidantes muestran un papel activo.
Development and verification of a novel blood viscoelastic monitoring method based on reciprocating motion of magnetic bead
Authors: Du Xinyu , Chen Fupan , Gan Lijin , Liu Yong , Zheng Yu , Xing Linghua , Zhou Qi 
Published: December 2022

Abstract
Blood coagulation function is an essential index in clinical examination, and it is of great significance to evaluate blood coagulation function comprehensively. Based on the blood viscoelasticity theory and hydrodynamics, we proposed a method to monitor the whole blood coagulation process based on the reciprocating motion of the magnetic bead (magnetic bead method for short). We have established a mathematical model between the moment acting on the magnetic bead and the viscoelasticity of blood in the process of blood coagulation. The change of blood viscoelasticity acks on the magnetic bead in the form of moment changes, which shows that the amplitude of the motion of the magnetic bead varies with the change of blood viscoelasticity. Designed and verified a blood coagulation monitoring device based on the reciprocating movement of the magnetic bead and discussed the device’s parameters through the orthogonal experiment. Lastly, the TEG5000 was used as the control group to test the thromboelasticity of four groups of thromboelastography quality control products in the same batch and 10 groups of human whole blood. It verified that our device has good repeatability, and has good consistency with TEG5000, it has particular application potential as a new blood coagulation monitoring method.
The impact of a professional development MOOC on the teaching beliefs of University Science Laboratory Teachers
Authors: Brouwer Natasa , Fleerackers Gunther , Maciejowska Iwona , McDonnell Claire , Mocerino Mauro 
Published: December 2022

Abstract
This study contributes to the understanding of online professional development of university STEM (Science, Technology, Engineering and Mathematics) lecturers. An active learning massive open online course (MOOC) to develop best practice in teaching in university science laboratories was developed using the ADDIE (Analysis, Design, Development, Implementation, Evaluation) model in three cycles. The teaching beliefs and intentions of the participants were determined before and after they completed the MOOC and their level of satisfaction with this professional development opportunity was examined using a survey. The results showed high completion rates and an appreciation of the online course design. Participants who completed the course evaluation were satisfied and they identified the usefulness of the active learning components that required them to discuss and reflect, develop plans and peer-assess. A large majority developed new ideas to help them to improve their teaching. The participation in the course increased participants’ understanding of the multidimensional aspects of laboratory teaching and the challenges related to it. The majority of participants changed their teaching beliefs to become more student-centred.
Modeling (im)precision in context
Authors: Mühlenbernd Roland , Solt Stephanie 
Published: December 2022

AbstractSpeakers’ choice between linguistic alternatives often depends on the situation, a prime example involving level of precision at which numerical information is communicated. We report on a production study in which participants report the time of an event in two different situations, and demonstrate that the results can be reproduced by a probabilistic game-theoretical model in which the speaker’s choice reflects a tradeoff between informativity, accuracy and hearer-oriented simplification. These findings shed light on the pragmatics of (im)precision, and the dynamics of situationally driven pragmatic variation more generally.
Statistical Analysis of Morphometric Data for Pottery Formal Classification: Variables, Procedures, and Digital Experiences of Medieval and Postmedieval Greyware Clustering in Catalonia (Twelfth–Nineteenth Centuries AD)
Authors: Allepuz Esther Travé 
Published: December 2022

Abstract
Formal analysis of pottery is a commonplace for most archaeologists regardless of the area or period of study. The typological study of utilitarian earthenware is complex and has often been neglected in pottery studies devoted to the analytical characterization of vessels. Certainly, a low degree of variability and standardization can jeopardize a definition of vessel typologies with some sense of universality. Despite this, a global approach dealing with the function or technology of the vessels should also include typological aspects, since they are relevant at the microscale levels and have significance in determining technical choice or distribution. In the last decade, we have analysed and quantified a vast amount of medieval greyware pottery assemblages. The generation of datasets of morphometric variables and their investigation via principal component analysis, among other statistical approaches and graphical representations, has led us to the identification of regional typologies with chronological meaning among these coarse, plain, and highly functional vessels fired under reducing conditions. Clusters resulting from a combined study including up to four diameters, wall thickness, absolute, preserved or reconstructed height, and vector profile measurement allowed us to determine the degree of breakage and to consider this variable in the typological definition.
Color Galore in the French Colonial Empire
Authors: Simonetti Marie-Agathe 
Published: December 2022

Abstract
Léon Busy (1874–1951) was an amateur photographer mostly known for his autochromes made in French Indochina for Albert Kahn’s multimedia collection “Les Archives de la planète” (Archives of the Planet). In addition to being an operator for Kahn, this article casts light on a less studied part of Busy’s life: his engagement with the French government of Indochina as of 1921. He exhibited his autochromes at the colonial exhibitions in Marseille (1922) and Paris (1931) and also served as head of the photographic section of the Office indochinois du Tourisme et de la Propagande (Indo-Chinese office of tourism and propaganda). This article provides an insight into my current research project and intends to demonstrate Busy’s instrumental role in producing colonial propaganda in color for the French government.
High-pressure synthesis and crystal structure determination of Tb2SiB2O8
Authors: Teichtmeister Tobias A. , Hladik Michael M. , Huppertz Hubert 
Published: December 2022

Abstract
We report the high-pressure/high-temperature synthesis (11 GPa, 1300 °C) of the new compound Tb2SiB2O8. This rare earth borosilicate crystallizes in the orthorhombic space group Pbcn (no. 60) with the unit cell parameters a = 13.2480(3), b = 4.3904(1), and c = 9.1611(3) Å. It is built up of corner-sharing [BO4] tetrahedra forming infinite chains, that are connected to layers via [SiO4] tetrahedra. The layers are connected via [TbO7] polyhedra.
Anonazepine, a new alkaloid from the leaves of Annona muricata (Annonaceae)
Authors: Huynh Ngoc Vinh , Nguyen Huu Duc Minh , Huynh Ngoc Trinh , Chau Duc Hoa , Nguyen Cong Dinh , Nguyen Truong Quoc Dung , Mai Dinh Tri , Dang Phu Hoang 
Published: December 2022

Abstract
From the CHCl3-soluble extract of Annona muricata L. (Annonaceae) leaves, one new 3-benzazepine-type alkaloid, anonazepine (1), and four known aporphine-type alkaloids, (+)-laurotetanine (2), (+)-norglaucine (3), (−)-xylopine (4), and lanuginosine (5), were isolated. Except for (−)-xylopine (4), these remaining known alkaloids were first reported in A. muricata. The structures of the isolated alkaloids were established by 1D and 2D NMR spectroscopy and MS, as well as comparison with literature data. The new 3-benzazepine-type alkaloid existed in an inseparable mixture of two equilibrium conformers. Its absolute configuration was determined based on comparing their experimental and calculated ECD data. The anti-inflammatory activity of the isolated alkaloids was investigated, but none of the alkaloids showed a significant result.
use of HbA1c for new diagnosis of diabetes in those with hyperglycaemia on admission to or attendance at hospital urgently requires research
Authors: Manley Susan Elisabeth , Karwath Andreas , Williams John , Nightingale Peter , Webber Jonathan , Raghavan Rajeev , Barratt Alison , Webster Craig , Round Rachel , Stratton Irene , Gkoutos Georgios , Roberts Graham , Mostafa Samiul , Ghosh Sandip 
Published: December 2022

The prevalence of diabetes in Birmingham is 11% but it is 22% in hospital inpatients. Queen Elizabeth Hospital in Birmingham (QEHB) serves a multi-ethnic population with 6% Afro-Caribbean, 19% South Asian and 70% White European.
A clinical audit of 18,965 emergency admissions to QEHB showed that 5% were undiagnosed but had admission glucose in the ‘diabetes’ range and 16% were in the ‘at risk’ range. The proportion of Afro-Caribbeans (7%) and South Asians (8%) in the ‘diabetes’ range was higher than White Europeans (5%). Given the magnitude of the problem, this paper explores the issues concerning the use of reﬂex HbA1c testing in the UK for diagnosis of diabetes in hospital admissions. HbA1c testing is suitable for most patients but conditions affecting red blood cell turnover invalidate the results in a small number of people.
However, there are pertinent questions relating to the introduction of such testing in the NHS on a routine basis. Literature searches on a topical question ‘Is hyperglycaemia identiﬁed during emergency admission/attendance acted upon?’, were performed from 2016 to 2021 and 2016 to 2022. They identiﬁed 21 different, relevant, research papers - 5 from Australia, 9 from Europe including 4 from the UK, 5 from America and 1 each from Canada and Africa. These papers revealed an absence of established procedures for the management and follow-up of routinely detected hyperglycaemia using HbA1c when no previous diabetes diagnosis was recorded.
Further work is required to determine the role of reﬂex HbA1c testing for diagnosis of diabetes in admissions with hyperglycaemia, and the cost-effectiveness and role of point-of-care HbA1c testing.
Selection of Target Mean Arterial Pressure in Severely Burned Patients with Septic Shock
Authors: Kleuzovich A. A. , Kazyonnov V. V. , Kudryavtsev A. N. , Geyze A. V. , Plotnikov G. P. , Alekseyev А. A. 
Published: December 2022

The timely diagnosis of both sepsis and septic shock can be challenging in severely burned patients. Monitoring methods providing early diagnosis of organ dysfunction development are of great importance. Assessment of the glomerular filtration rate with central hemodynamic parameters can be considered as a component of comprehensive monitoring of effectiveness of septic shock therapy.Aim: to determine the relationship between the target mean arterial pressure and glomerular filtration rate parameters in the treatment of severely burned patients with septic shock.Material and methods. 158 severely burned patients with septic shock were included in the study, of them 121 patients represented a retrospective historical group, and 37 patients constituted a prospective group. The main criteria of treatment efficacy were 28-day and hospital mortality.Results. In the patients of prospective group, 28-days mortality decreased down to 16.2% compared with 33.9% in the retrospective group, and hospital mortality dropped down to 29.7% vs 42.1%, respectively (P<0.05). Conclusion. Extended hemodynamic and metabolic (renal function assessment) monitoring of intensive therapy of severely burned patients with septic shock helps targeted adjustment of ﬂuid therapy and provides earlier beginning of extracorporeal blood therapy thus favoring better survival rate.
Readjustment of a robot for educational purposes
Authors: Szabó Sándor Imre , Rónai László 
Published: December 2022

AbstractDevelopment of control of a five degrees of freedom robot is discussed in this paper. Only two robots were made, and one of these is in the University of Miskolc. The robot was made in the 80s for educational purposes, the electronic components were obsolete and control software was missing, therefore it became necessary to perform hardware improvements, and develop a new control program. Inverse kinematics problem of the robot is solved by geometric approach to formulate the joint angles, which will form the basis of the control. A braking system containing electromagnets for the robot is constructed to balance it. A printed circuit board is designed to establish the control of the system, the central element is a Cypress PSoC 5LP platform. The development of the control program is performed in software PSoC Creator 4.4. The developed control system of the robot can receive instructions from a computer via a designed special purpose user program, which is written in Python programming language. Thanks to the improvements, the robot has become operational. Thus, the robot can serve educational purposes performing different manipulation tasks. By completing the developments, students can get to know the structure and programming of the robot, its inverse kinematics problem. This will require the development of practice-oriented tasks in the future.
ДО ПРОБЛЕМИ РОЗРАХУНКУ ПРОЦЕСУ ЕКСТРАГУВАННЯ ІЗ РОСЛИННОЇ СИРОВИНИ
Authors: Дячок Василь Володимирович , Венгер Любов Олександрівна 
Published: December 2022

Відмінною рисою твердих тіл клітинної будови (органічного походження), а такою є рослинна сировина, на противагу твердим тілам мінерального походження, є те, що внутрішня анатомічна будова передбачає наявність двох середовищ – клітинного та міжклітинного. Такі об’єкти дослідження при контакті з екстрагентом – найчастіше водою або водно-спиртовими розчинами володіють властивістю набухати, що в кінцевому підсумку спричиняється до зростання їх геометричних розмірів. Окрім цього, процес набухання завжди супроводжується розчинення компонентів, які містяться у внутрішньому об’ємі твердого тіла з подальшою їх дифузія за межі границі розподілу фаз. Це явище також спричиняється до збільшення об’ємів міжклітинного та клітинного середовищ в порівнянні з вихідною сухою сировиною. Нарешті суттєве значення на величину об’ємів клітинного та міжклітинного середовищ має анатомічна будова різних морфологічних органів рослинної сировини, тобто листя, стебло, корені з кореневищами, плоди, тощо.
У роботі теоретично обґрунтована та практично показана можливість експериментально визначення об’ємів міжклітинного та клітинного середовищ об’єктів екстрагування, які мають клітинну будову. В основу способу закладені теоретичні положення масообмінних процесів в системі тверде тіло – рідина. Запропонований спосіб визначення об’ємів міжклітинного та клітинного середовищ твердих тіл рослинного походження поглиблює знання в галузі розроблення методології прогнозування процесу екстрагування. Абсолютні значення визначених об’ємів дають можливість розраховувати значення коефіцієнтів дифузії біологічно активних сполук в об’ємі міжклітинному середовищі та через клітинну мембрану тим самим встановлювати режими процесу екстрагування, прогнозувати кінетику вилучення цільових речовин при проведенні процесу екстрагування на виробництві, а також розробляти методології розрахунку процесів екстрагування із твердих тіл рослинної сировини, що сприятиме проведенню виробничих процесів екстрагування в цифровому режимі. Узагальненні закономірності екстрагування із рослинної сировини розширюють уявлення про масообмін в системі тверде тіло – рідина та мають перспективу застосування для розроблення теорії моделювання процесів екстрагування.