bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correction: Boron‐dependent microstructural evolution, thermal stability, and crystallization of mechanical alloying derived SiBCN
Authors: Li Daxin , Yang Zhihua , Jia Dechang , Cai Delong , Wang Shengjin , Chen Qingqing , Zhou Yu , Yu Dongli , Tian Yongjun 
Published: February 2025

AbstractIn this paper, the amorphous boron‐rich SiBCN powders were prepared by high‐energy ball‐milling of the mixtures of inorganic Si, graphite, h‐BN, and boron. The solid‐state amorphization, thermal stability, and crystallization of the resulting SiBCN powders were studied in detail. Results showed that mechanical alloying can drive solid‐state amorphization but also can be an initiation step for the nucleation of few SiC nanocrystals. The amorphous networks containing Si‐C, C‐B, C‐C, C‐N, BN, and C‐B‐N bonds are detected; however, solid‐state NMR further confirms the formation of a new chemical environment around B atoms, BC3. The increases in boron content improve the thermal stability of SiBCN ceramics but weaken their oxidation resistance. Nano‐SiC crystallizes first while BN(C) forms subsequently. Increasing boron content promoting SiC crystallization may result from the reduced hindering effects of B‐N‐C nanodomains that retard SiC crystallization.
Impact of Tricuspid Regurgitation on Atrial Fibrillation Recurrence After Pulmonary Vein Isolation
Authors: Weyand Sebastian , Adam Viola , Biehler Paloma , Hägele Patricia , Hanger Simon , Löbig Stephanie , Pinchuk Andrei , Ausbuettel Felix , Waechter Christian , Seizer Peter 
Published: February 2025

ABSTRACTBackgroundThe impact of tricuspid regurgitation (TR) on the outcomes of pulmonary vein isolation (PVI) for atrial fibrillation (AF) remains unclear. While the effects of mitral regurgitation (MR) on PVI outcomes are well‐documented, there are limited data on how moderate or greater TR influences PVI efficacy and recurrence rates.ObjectivesThe aim of this study was to assess the impact of moderate or greater TR on the outcomes of PVI, particularly focusing on AF recurrence rates within the first year post‐PVI.MethodsWe conducted an observational cohort study involving 421 patients undergoing their first PVI. 96 patients with moderate or greater TR were propensity score‐matched with 96 controls based on age, sex, body mass index, and MR severity. Procedural parameters, complication rates, and AF recurrence within 1‐year post‐PVI were analyzed.ResultsDespite comparable procedural parameters and low overall complication rates between the groups, patients with moderate or greater TR experienced significantly higher AF recurrence rates within the first year after PVI. Right atrium (RA) area was notably larger in these patients, suggesting a potential link between RA remodeling and increased AF recurrence.ConclusionsOur findings indicate that moderate or greater TR is associated with higher recurrence rates of AF after PVI, potentially due to RA enlargement and remodeling. This highlights the need for tailored ablation strategies that consider the RA substrate and/or TR treatment in patients with significant TR and AF. Further multicenter, prospective studies are required to validate these results and explore long‐term outcomes.
3D Printed Provisional Removable Partial Denture Designed Using Virtual Patient for a Road Traffic Accident Victim
Authors: de Sousa Lucas Cavalcante , Curinga Míria Rafaelli Souza , Galvão Cecília Santos , Lam Walter Yu Hang , Carreiro Adriana da Fonte Porto 
Published: February 2025

ABSTRACTObjectiveProvisional removable partial denture (RPD) preserves esthetic and functional parameters until definitive treatment. This clinical report presents a 19‐year‐old victim of a road traffic accident who lost the maxillary right central and lateral incisors.Clinical ConsiderationsA 3D printed maxillary provisional RPD planned using a virtual patient was provided until the patient could undergo implant‐supported rehabilitation. Intraoral and facial scans were conducted, and the images were integrated into a dental software program for digital prosthetic planning. The provisional RPD was designed considering the facial parameters, then 3D printed, characterized, and delivered to the patient.ConclusionsThe 3D printed provisional RPD demonstrated satisfactory esthetic and functional outcomes, offering a faster and more predictable alternative compared to the conventional method.Clinical SignificanceUsing virtual patients to design 3D printed provisional removable partial dentures can enhance the predictability of treatment, especially in the esthetic area.
Characterisation of Lumpfish (Cyclopterus lumpus L.) Skin and Development of a Digital Histomorphometric Tool to Analyse It
Authors: Johansson Gunhild Seljehaug , Ytteborg Elisabeth , Timmerhaus Gerrit , Johansen Lill‐Heidi 
Published: February 2025

ABSTRACTLumpfish are commonly used as cleaner fish in the production of Atlantic salmon as a preventive measure against sea lice. This, and other procedures, are stressful and may harm the cleaner fish. In this work, lumpfish skin was studied to understand this organ better and to develop tools to analyse and monitor lumpfish skin health. Three different sample sets were used: preadult lumpfish from a land‐based hatchery, adult lumpfish from a salmon farm and adult lumpfish before and after a delousing at a commercial salmon farm. We developed a digital histomorphometric algorithm in Aiforia to better quantify structures and measure skin features and to study the effects of delousing treatment on lumpfish skin. Results show that lumpfish skin is highly complex. The specific cells and their integrity are important for the fish to maintain homeostasis and protect against the outer environment. Damages in skin are induced during or after delousing, and these damages may make the fish more susceptible to secondary infections. The detected damages may be difficult to observe through visual inspections, and in‐depth analyses at the cellular level may be needed to understand the impact of different stressors on lumpfish health.
Use of Indices Combining Diastolic and Systolic Tissue Doppler Variables to Evaluate Right Ventricular Function in Dogs With Pulmonary Stenosis
Authors: Winter Randolph L. , Maneval Kara L. , Ferrel Claudio Serrano 
Published: February 2025

ABSTRACTBackgroundIndices combining diastolic and systolic tissue Doppler variables, the Ee′s′ index (E/[e′ × s′]) and e′a′s′ index (e′/[a′ × s′]), have aided detection of myocardial dysfunction and in prediction of poor outcomes in humans with cardiovascular diseases. Studies of Ee′s′ and e′a′s′ indices in dogs have not been performed.Hypothesis/ObjectivesDogs with pulmonary stenosis (PS) have elevated right ventricular (RV) Ee′s′ and e′a′s′ indices compared to healthy dogs, which will decrease after pulmonary balloon valvuloplasty (BV) or stent implantation.AnimalsThirty client‐owned dogs (15 healthy, 15 with PS).MethodsCross‐sectional study. All dogs had echocardiography performed, including the measurement of RV diastolic and systolic variables and calculation of the Ee′s′ and e′a′s′ indices. Dogs with PS had echocardiography performed prior to and after interventional procedures.ResultsThe Ee′s′ index was lower (p = < 0.001) in healthy dogs (median 0.43, range 0.23–0.74) compared to dogs with PS pre‐operatively (1.49, 0.28–3.79). The e′a′s′ index was lower (p = 0.039) in healthy dogs (mean 8.03 ± 3.28) compared to dogs with PS pre‐operatively (11.39 ± 4.03). Compared to pre‐operative values, the Ee′s′ index (1.01, 0.36–1.62) and e′a′s′ index (8.35 ± 3.29) decreased (p = 0.018, p = 0.001, respectively) after pulmonary intervention in dogs with PS.Conclusions and Clinical ImportanceDogs with PS have RV myocardial dysfunction that can be measured with Ee′s′ and e′a′s′ indices, and these values can be used to monitor response to pulmonary intervention over time. These findings suggest that calculation of Ee′s′ and e′a′s′ indices might have clinical importance in long‐term management of dogs with PS.
Sexual dichromatism increases with altitude in birds with ultraviolet sensitive vision
Authors: Villar D. A. , Marino Jorgelina , Gosler Andrew G. 
Published: February 2025

AbstractThe harsher environment of higher altitudes increases selection for biparental care and increases extrinsic mortality, both of which are expected to reduce the strength of sexual selection. The intensity of sexual selection is often studied using sexual dimorphism as a proxy, especially sexual dichromatism. In birds, multiple studies have shown that sexual dichromatism decreases with increasing altitude. However, those studies have either used small datasets or have used human scoring of sexual dichromatism, potentially missing out on significant levels of cryptic dichromatism. This study includes the measure of subjective sexual dichromatism of the Vorobyev‐Osorio colour discrimination model of sexual dichromatism in 758 species of bird with UV‐sensitive visual systems and tests whether a relationship exists between altitude and sexual dichromatism. We found a significant positive relation between altitude and sexual dichromatism when accounting for the UV‐sensitive vision of Passeriformes, Charadriiformes, Psittaciformes and Struthioniformes, but not when dichromatism is measured using human scoring. This suggests that there might be a greater selection pressure for females to select high‐quality males in harsher, higher altitude, environments and that this signalling is primarily done in the ultraviolet range. We suggest that macroecologists should pay closer attention to the receiver psychology of signals even when studying a large number of species and that not doing so could lead to misleading or spurious macroecological and/or macroevolutionary patterns.
Effects of Remote Ischemic Conditioning on Postoperative Recovery After Hepatectomy: A Randomised Controlled Trial
Authors: Tian Chun , Tian Hongni , Li Wenlang , Chen Jie , Guo Qiao , Duan Guangyou , Huang He 
Published: February 2025

ABSTRACTBackground and AimsRemote ischemic conditioning (RIC) has shown promise in preclinical and clinical studies, but its effectiveness in reducing hepatic ischemia–reperfusion injuries (HIRIs) and enhancing postoperative recovery after hepatectomy remains uncertain. In this study, we aimed to evaluate the impact of perioperative RIC (PRIC) on postoperative recovery in patients undergoing hepatectomy.MethodsA randomised controlled trial was performed. A total of 135 eligible patients were randomised to either a control group (sham RIC), a PRIC‐1 group (RIC once daily for 3 days starting on the day of surgery) or a PRIC‐2 group (RIC twice daily). The primary outcome was the time to 2 times the upper limit of normal (2ULN) alanine transaminase (ALT) levels post‐hepatectomy. Secondary outcomes included time to reach 2ULN for aspartate transaminase (AST) levels, the area under the concentration–time curve on postoperative Day 7 (AUC‐POD7) for ALT, AST, total bilirubin and lactic acid, as well as assessments of gastrointestinal function and postoperative complications.ResultsMedian time to 2ULN ALT was shorter in the PRIC‐1 and PRIC‐2 groups than in the control group (PRIC‐1: 5.0 [3.5, 6.0] vs. control: 7.0 [7.0, 10.0] days, p < 0.001; PRIC‐2: 5.0 [4.0, 8.0] vs. control: 7.0 [7.0, 10.0] days, p < 0.001). The AUC‐POD7 for ALT and AST, time to 2ULN AST, time to gastrointestinal tolerance and postoperative complications were significantly improved in the PRIC groups compared with thecontrols.ConclusionsPRIC is safe and effective in reducing HIRIs and enhancing recovery post‐hepatectomy. Once‐daily PRIC offers similar benefits to twice‐daily PRIC.Trial RegistrationNCT06130436 (ClinicalTrials.gov)
Agreement between extrapolated corneoscleral topographical data obtained during natural and retracted eyelid positions
Authors: Hughes Rohan P. J. , Iqbal Asif , Hoffmann Grace , Holden Joseph , Kitson Rebecca , Nguyen‐Tran Huan , Thompson Erika , Xiao Julie , Vincent Stephen J. 
Published: February 2025

AbstractPurposeTo examine the influence of aperture size (corneoscleral data coverage) on extrapolated scleral sagittal height data generated by the Pentacam HR derived from the Corneo Scleral Profile (CSP) software, by comparing measurements obtained during natural and retracted eyelid positions.MethodsCorneoscleral topography of the left eye of 20 young (age: 22 [3] years) healthy adults with normal corneas was measured using the Pentacam HR CSP with the eyelids in their natural primary gaze resting position and during eyelid retraction with a wire speculum. The measured and extrapolated sagittal height data were exported from the instrument and analysed over a range of chord diameters (10.0, 12.5, 15.0 and 17.5 mm) and locations (superior, inferior, nasal and temporal) using customised software.ResultsEyelid retraction increased data coverage (% of available data points within 360°) for the 12.5 and 15.0 mm chord diameters (by 25% and 35%, respectively, p < 0.001), but by less than 10% for the 10.0 and 17.5 mm chord diameters. Significant differences in extrapolated sagittal height data were observed between the natural and retracted eyelid positions with respect to chord diameter and location (both p < 0.001), with the greatest difference observed superiorly for a 17.5 mm chord diameter (mean extrapolated sagittal height difference, retracted minus natural: −447 ± 401 μm, p < 0.0001).ConclusionsEyelid retraction substantially increased data coverage for the 12.5 and 15.0 mm chord diameters. Significant differences in the extrapolated sagittal height data generated from measurements obtained during natural and retracted eyelid positions were observed for the superior location (12.5, 15.0 and 17.5 mm chord diameters) and inferior and nasal locations (17.5 mm chord diameter). Extrapolated sagittal height values obtained during the natural eyelid position were typically greater than those obtained with eyelid retraction, most likely due to the amount of measured data available for extrapolation.
Toxoplasma gondii (GRA10): A Closer Glance Into Immunogenic and Biochemical Characteristics Using In Silico Approach
Authors: Khadem Mohammadi Mahdi , Ghaffari Ali Dalir 
Published: February 2025

ABSTRACTToxoplasma gondii, an obligate, intracellular, protozoan parasite, is known to infect a wide range of warm‐blooded animals, including livestock, marine mammals and humans leading to the development of toxoplasmosis. The dense granule antigens (GRAs) have garnered crucial role in parasite survival, virulence and the formation of the parasitophorous vacuole. The study focusing on the GRA10 protein of T. gondii aims to elucidate its features further to support its potential inclusion in future vaccine formulations. The present study provided an exhaustive elucidation of the key characteristics of the GRA10 protein, encompassing its presence of a transmembrane domain, physico‐chemical properties, subcellular localization, potential epitopes recognised by B‐cells and T‐cells, secondary and tertiary structures, as well as other significant attributes of this protein. The results indicated that the GRA10 protein possesses a total of 192 possible post‐translational modification sites, with no transmembrane domains being detected within its structure. In terms of secondary structure, the GRA10 protein is composed of 27.74% alpha‐helix, 13.53% extended strand and 58.72% random coil elements. Additionally, various potential B‐ and T‐cell epitopes were pinpointed for the GRA10 protein, suggesting its immunogenic properties. The assessment of antigenicity and allergenicity further confirmed that GRA10 is immunogenic but non‐allergenic, making it a promising candidate for further study. Furthermore, the induction of IFN‐γ and IL‐4 highlighted the ability of related MHC‐II molecules to interact with GRA10, indicating its potential role in immune responses. These findings shed light on the multifaceted nature of the GRA10 protein and its significance in immunological processes. The study presented crucial fundamental and theoretical information regarding GRA10 in order to facilitate the creation of a potent vaccine against both acute and chronic toxoplasmosis, warranting additional in vivo examinations.
A Review and New Insights Into Spermatogenesis From Single‐Cell RNA Sequencing
Authors: Wang Zhiqiang , Xiao Nan , Han Qing , Qi Yunjia , Shi Deshun , Luo Chan 
Published: February 2025

ABSTRACTAs the most primitive germ cells in the testis, spermatogonial stem cells (SSCs) not only constantly renew themselves to ensure their quantity, but also differentiate into mature sperm cells to complete spermatogenesis and transmit genetic information to the next generation. Successful spermatogenesis is inseparable from niche regulation, which provides factors that enhance the self‐renewal of SSCs to maintain their numbers and directs the appropriate differentiation of spermatogonia. Some progress has been achieved in the definition and isolation of SSCs. However, a high degree of cellular heterogeneity is found in the testis, revealing a combination of various cell types at different developmental stages and a lack of specific molecular markers (especially in domestic animals) for fully screening and purifying SSCs. These factors have considerably hindered further research into the mechanisms of maintenance, self‐renewal, and differentiation of SSCs, as well as limited their isolation, purification, and applications. Accumulated studies have recently successfully employed single‐cell RNA sequencing (scRNA‐seq) as a novel approach to detailing the classification of cell subsets, mining specifically expressed genes in different cell types, and accurate identification of specific cell types. This review summarises the progress of SSCs identification and offers new insights into the SSCs developmental trajectory from single‐cell RNA sequencing.
Water outage predictions for natural hazards using synthetic water distribution systems
Authors: Pagan‐Cajigas Zaira , Guikema Seth , Otaduy‐Ramirez Rosalia , Woolley Vanessa , Smith Kaleb , Hu Tongxing , Chen Thomas 
Published: February 2025

AbstractHazards can impact water systems, leading to water outages that result in economic, environmental, and societal losses. Modeling a system's behavior helps develop short‐term restoration strategies and long‐term resilience planning. However, data on the topology and operational characteristics of real water systems are often unavailable outside of the utility operating the system, limiting the ability of others depending on the system to understand its vulnerability and resilience. We address this limitation by developing an algorithm that generates a synthetic water distribution system using only publicly available data. Our approach provides hydraulic information at the building level to support infrastructure resilience assessments. We validated our model by comparing the network topologic and hydraulic properties with data from the real water system of Ann Arbor, Michigan. Our synthetic model results indicate that 95% of the simulated building‐level pressures were within PSI of the hydraulic model data from the existing system. To demonstrate an application of our model, we simulated water outages at the building level using hazard loading and fragility functions corresponding to an earthquake scenario.
Affected Realism and Imitated Perception: Ekphrasis and Orthodox Space in Leskov and Chekhov
Authors: Roberts Tom 
Published: February 2025

AbstractNikolai Leskov and Anton Chekhov frequently portray Russian Orthodox sites and services in their fiction. Examining Leskov’s novella The Sealed Angel, and three early Chekhov stories, this article explores how the two authors represent Orthodox liturgical space through the Byzantine technique of ekphrasis, a descriptive method used to present church architecture in sermons, hymns, encomia, and prayers. Rather than objectively describing church architecture and interior space, ekphrasis reproduces the site’s aesthetic and affective impact on the speaker, who recounts this idealized experience to evoke an emotional response. Ekphrastic technique therefore contradicts mimetic procedures of realist representation, prioritizing the impression produced by the material image over descriptive accuracy. Leskov and Chekhov present Orthodox sites as they are imaginatively perceived, in idealist approximations of liturgical space that more faithfully reflect the nature of liturgical experience. Both authors dramatize character point of view and voice to call forth an embodied, affective experience of Orthodox space—transposing the reader to a fictive setting, and simulating spatial presence and perception. By reviving classical ekphrasis, Leskov and Chekhov also parody realist mimetic conventions, and advance the historical development of realism itself.
Associations of 24‐h Movement Behaviors With Incidence of Cardiovascular Risk Factors: The Finnish Retirement and Aging Study
Authors: Suorsa Kristin , Leskinen Tuija , Pasanen Jesse , Pentti Jaana , Vahtera Jussi , Stenholm Sari 
Published: February 2025

ABSTRACTLow physical activity, high sedentary time (SED), and inadequate sleep increase cardiovascular disease risk, but the codependency between these 24‐h movement behaviors has often been neglected. This study examined associations between 24‐h movement behaviors and incidence of cardiovascular risk factors. The study included 866 adults (mean age 62.4 years, SD 1.1) from the Finnish Retirement and Aging study who participated in wrist‐accelerometry measurements between 2014 and 2018. Incident register‐based cardiovascular risk factors including hypertension, dyslipidemia, type 2 diabetes, and questionnaire‐based obesity were followed up over on average 3‐year follow‐up. Compositional Cox regression models were adjusted for age, sex, occupation, smoking, and heavy alcohol consumption. We recorded 84 (17%) new cases of hypertension, 66 (9%) dyslipidemia, 28 (3%) type 2 diabetes, 43 (6%) obesity, and 94 (26%) any of these cardiovascular risk factors. Compared to mean composition (7.8 h sleep, 11.0 h SED, 4.2 h light physical activity [LPA], 60 min moderate‐to‐vigorous physical activity [MVPA]), having 10 min more MVPA at the cost of other behaviors was associated with 5%–7% risk reduction in hypertension, 10%–13% in obesity, and 6%–7% in any cardiovascular risk factor. Among the least active (sleep 7.9 h, SED 12.1 h, LPA 3.6 h, MVPA 24 min), the risk reductions were nearly twofold. In conclusion, when accounting the interdependence of movement behaviors, MVPA associated with highest risk reduction in hypertension and obesity, especially among the least active participants. This suggests that even a small increase in daily MVPA could help prevent development of cardiovascular risk factors.