bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Multiphase Flow in Shale Oil Reservoirs Considering Multiscale Porous Media by High-Resolution Numerical Simulation
Authors: Lei Zhengdong , Li Junchao , Chen Zhewei , Dai Xu , Ji Dongqi , Wang Yuhan , Liu Yishan 
Published: July 2023

Summary
Multiphase flow behavior in the complex porous media of lacustrine shale oil is critical to the oil production performance. Shale oil reservoir processes spatial spaces of multiscale porous media. In view of the mesoscopic scale, the fluids flow behaviors of shale oil reservoirs are significantly different from that of tight oil reservoirs and the multimedia flow fluxes in shale have to be reevaluated. Furthermore, upscaling methods from the mesoscopic scale to the macroscopic level as well as coupling methods of multimedia mass transfer have not been adequately established. Based on the multiple media model, such as organic-inorganic matter system and embedded discrete fracture model (DFM), this work proposes a multiscale porous media flow simulation method that is applicable for lacustrine shale oil reservoirs. In the model, various reservoir matrix and flow spaces, such as organic pores, intragranular pores, intergranular pores, and fracture networks composed of bedding fractures and hydraulic fractures, are included. Methods of mass flux conductivity estimations among multiscale media and the relevant upgrading methods are also proposed. Validation of the model is first conducted by the comparison of the oil production performance estimated by the proposed model and a theory solution, and the model is further compared to Gulong shale oil reservoir data to determine its availability in field application. The results show that the proposed simulation model is capable of accurately characterizing the multiphase flow characteristics in multiscale media in shale. It is further demonstrated that the proposed model significantly improves the simulation accuracy over the current nonupscaling models. Field study shows that, based on the accurate characterization of the complex flows in shale oil reservoirs, the research output can provide support for future development of the Gulong shale oil reservoir.
How does dental treatment affect oral health of patients received radiotherapy and bone-modifying agent: systematic review
Authors: AlSahman Roba , AlSahman Lujain , Alturiaki Sami 
Published: July 2023

Abstract
Background: Radiotherapy and bone-modifying agents are widely used to treat malignancies and metastases. Bone-modifying agents and radiation-related adverse effects on oral health detrimentally affect dental treatment outcomes. Two common complications occur during and after radiotherapy: bone-modifying medications, osteoradionecrosis, and osteonecrosis of the bones. Dental professionals play an important role in evaluating procedures that can potentially cause these complications.
Objective: This systematic review aimed to evaluate the effects of dental treatment on oral health in patients who had received radiotherapy and bone-modifying agents.
Methods: A comprehensive search was conducted using PubMed, Scopus, Web of Science, Embase, Medline, Proquest, and Cochrane Library from 2015-2023 following PRISMA guidelines.
Results: Eighteen articles, published between 2015 and 2023, were reviewed. Dental implants have been the main focus of attention in most studies, as radiation therapy can reduce the microhardness of enamel and dentin and increase the risk of osteoradionecrosis (ORN) and tooth failure. However, dental implants can still be successful with proper bone quality and implant techniques, and bisphosphonate therapy does not significantly affect implant failure.
Conclusion: The risk of developing osteonecrosis was not significant, but was increased by parenteral administration compared with oral administration. Bisphosphate is associated with deep pockets, higher bleeding index, and pulp obliteration.
Environmental Innovation, Ecological Footprint, and Environmental Rebound Effects: A Solution for or a Cause of Environmental Degradation?
Authors: Aydın Celil , Esen Ömer , Çetintaş Yağmur 
Published: July 2023

Abstract
This paper investigates the effect of environmental innovation on ecological footprint using a PSTR model. To examine this impact, a large panel dataset covering 26 EU economies1 for the period 1990–2010 is exploited. The estimated findings point out that below the threshold level, environmental pressure on per capita ecological footprint increase with environmental innovation, after exceeding the threshold level, the rate of increase in pressure is still positive but tends to decrease. Existing empirical results point to a rebound effect, which refers to offsetting the gains from environmental innovation by channeling them into production and consumption. This paper suggests that policymakers take into account that environmental innovations alone do not reduce pressure on Earth's ecosystems and their life-supporting services, but can provide resources to reduce this pressure.
[1] The list of 26 EU countries is in Table 1 in Appendix.
Practical lessons from the implementation of a surgical opioid reduction initiative in an integrated health system: a qualitative study among providers and patients
Authors: Schäfer Willemijn , Johnson Julie K. , Shallcross Meagan L. , Iroz Cassandra B. , Huang Reiping , Balbale Salva , Stulberg Jonah J. 
Published: July 2023

Abstract
Background
Surgical opioid overprescribing can result in long-term use or misuse. Between July 2018 and March 2019, the multicomponent intervention, Minimizing Opioid Prescribing in Surgery (MOPiS) was implemented in the general surgery clinics of five hospitals and successfully reduced opioid prescribing. To date, various studies have shown a positive outcome of similar reduction initiatives. However, in addition to evaluating the impact on clinical outcomes, it is important to understand the implementation process of an intervention to extend sustainability of interventions and allow for dissemination of the intervention into other contexts. This study aims to extract practical lessons through evaluation of the contextual factors impacting intervention implementation.
Methods
We conducted a qualitative study with semi-structured interviews held with providers and patients of the general surgery clinics of five hospitals of a single health system between March and November of 2019. Interview questions focused on how contextual factors affected implementation of the intervention. We coded interview transcripts deductively, using the Consolidated Framework for Implementation Research (CFIR) to identify the relevant contextual factors. Content analyses were conducted using a constant comparative approach to identify overarching themes.
Results
We interviewed 15 clinicians (e.g., surgeons, nurses), one quality representative, one scheduler and 28 adult patients and identified three key themes. First, we found high variability in the responses of clinicians and patients to the intervention. There was a strong need for intervention components to be locally adaptable, particularly for the format and content of the patient and clinician education materials. Second, surgical pain management should be recognized as a team sport. We identified specific gaps in the engagement of team members, including nurses. We also found that the hierarchical relationships between surgical residents and attendings impacted implementation. Finally, we found that established patient and clinician views on opioid prescribing were an important facilitator to effective implementation.
Conclusion
Successful implementation of a complex set of opioid reduction interventions in surgery requires locally adaptable elements of the intervention, a team-centric approach, and an understanding of patient and clinician views regarding changes being proposed.
Induction chemoimmunotherapy may improve outcomes to chemoradiotherapy for unresectable stage III NSCLC patients
Authors: Guan Song , Zhang Shufeng , Ren Kai , Li Xingyue , Li Xue , Zhao Lujun 
Published: July 2023

Abstract
Objective
Currently, the value of induction chemoimmunotherapy before chemoradiotherapy (CRT) in unresectable stage III non-small cell lung cancer (NSCLC) has not been established. This study aimed to investigate the role of induction chemoimmunotherapy for unresectable stage III NSCLC.
Patients and Methods
Patients diagnosed with stage III NSCLC who received CRT at Tianjin Cancer Hospital between August 2014 and December 2021 were retrospectively analysed. Based on induction chemoimmunotherapy or not, patients were allocated to I-CRT group or CRT group. Clinical outcomes including progression-free survival (PFS) and overall survival (OS) were estimated.
Results
A total of 255 patients were included, with 51 (20.0%) in the I-CRT group and 204 (80.0%) in the CRT group. The median PFS was 24.8 months in the I-CRT group vs. 12.6 months in the CRT group (p = 0.004), and the median OS was not reached (NR) vs. 32.4 months (p = 0.040). The multivariate analysis showed that induction chemoimmunotherapy was the independent factor favoring PFS (HR = 0.497, p = 0.003) and OS (HR = 0.459, p = 0.038). No significant differences were found in adverse effects (p > 0.05). The objective response rate (ORR) after induction chemoimmunotherapy was significantly higher than that after induction chemotherapy (56.9% vs. 22.2%, p = 0.000). Patients with induction chemoimmunotherapy before concurrent chemoradiotherapy had prolonged PFS (median NR vs. 14.9 months, p = 0.012) and OS (median NR vs. 26.5 months, p = 0.074) compared to those with induction chemotherapy.
Conclusion
Induction chemoimmunotherapy may improve outcomes to CRT and is well tolerated for unresectable stage III NSCLC patients. Prospective randomized trials need to be performed to further validate these findings.
Green Preparation of Flexible and Transparent SiO2-Fe2O3-PS film for Dye Adsorption and UV-Shielding Applications
Authors: Nath Abhijit , Mahato Mrityunjoy 
Published: July 2023

Abstract

A multifunctional green polymer nanocomposite (SiO2-Fe2O3-PS) film has been prepared using earth-abandoned and waste materials such as natural sand, waste expanded polystyrene (EPS), and pea eggplant fruit extract. SiO2 was prepared using natural sand by alkali fusion method, SiO2-Fe2O3 was prepared by microwave assisted green synthesis method and the SiO2-Fe2O3-PS film was prepared by solution casting method. The SiO2-Fe2O3 (20:80)-PS film shows the shielding efficiency of 91–100% in the wavelength range of 390 − 200 nm and transparency of 71% to visible light at 800 nm. The SiO2-Fe2O3 (50:50)-PS film shows maximum adsorption capacity of 61.2% to methylene blue (MB) dye. The UV-Vis peak position of SiO2 (326 nm) and Fe2O3 (276 nm) are in line with the literature. The peak position in SiO2-Fe2O3 at different wt% ratio, were found at 290 nm (10:90), 328 nm (20:80), and 292 nm (50:50), which are indicative of the formation of heterostructure. The XRD data of SiO2-Fe2O3 comprises sharp peaks of both components that confirm the heterostructure formation and its crystalline nature. The SiO2-Fe2O3-PS composite formation was confirmed by FTIR and FESEM. The film is hydrophilic in nature (contact angle of 75.96°) and shows maximum thermal stability upto 381.6 ℃ (SiO2-Fe2O3 (20:80)-PS). The adsorption experiment was carried out using a 50 mg catalyst either in powder or film form with 100 mL dye solution of concentration 20 mg/L, where equilibrium adsorption was achieved within 180 minutes. The adsorption efficiency of SiO2, Fe2O3, SiO2-Fe2O3 (20:80), SiO2-Fe2O3(50:50), and SiO2-Fe2O3(50:50)-PS are found to be 98.3%, 3.88%, 91.1%, 96.2%, and 61.2%, respectively. The MB dye adsorption process follows pseudo second order kinetics and is best fitted with the Langmuir isotherm model. The novel SiO2-Fe2O3-PS film is found to be low cost, green, and environmentally friendly with multifunctional applications in the area of UV shielding, visible transparent and dye adsorption.
Analysis of Tobacco Exposures and HR-HPV infection in American women：National Health and Nutrition Examination Survey
Authors: jiang liangzi , Ma Suting , Zhang Ge , Jiang Lingling , Yan Li 
Published: July 2023

Abstract
Nicotine is a known toxin, but its relationship with cervicovaginal high-risk human papillomavirus (HR-HPV) infection is uncertain. This study aimed to investigate whether tobacco exposure is associated with elevated cervicovaginal HR-HPV infection in US women, and if the strength of this association varies with the degree of exposure. Cross-sectional data from the 2011–2016 National Health and Nutrition Examination Survey (NHANES), which included a nationally representative sample of US women, were used for the study. Out of 12436 women aged 18–59 who participated in the interview, 3833 were ultimately enrolled in this study. Weighted logistic regression was used to estimate the link between tobacco exposure and cervicovaginal HR-HPV infection. The mean age of participants was 38.6 (SD 12.1) years, and non-Hispanic White individuals accounted for 37.3% of the sample. Those with any tobacco exposure tended to be younger (mean age 37.7 [SD 12.4] years vs 40.3 [11.2] years), non-Hispanic Black (27.8% vs. 15.1%), lower educated (41.8% vs. 29.4%), and have lower family income (39.9% vs. 23.5%). After adjustment, the odds of having HR-HPV infection were 1.32 (95% CI, 1.09–1.59) for those exposed to tobacco, remaining significant in multiple sensitivity analyses and across subgroups. This study, based on a nationally representative sample from the United States, suggests that tobacco exposure is a risk factor for elevated HR-HPV infection in women, highlighting the need for further research into reducing this modifiable risk factor.
Investigating the fracture behavior and energy absorption of new flexible hybrid biocomposites with soft and hard layers of rubber/lignin/CB and hemp fabric impregnated with matrix under high-velocity impact
Authors: ghiaskar ahmad , Nouri Mohammad Damghani 
Published: July 2023

Abstract
This paper compares the behavior and energy absorption of hybrid and conventional flexible composites with soft and hard rubber layers and fabrics impregnated with soft and hard matrix in different configurations of layer arrangement under high-velocity impact. For this purpose, two types of hard and soft rubber layers were produced by increasing the amount of lignin-carbon binary filler in rubber compounds. Also, a diluted hard and soft rubber matrix was used to impregnate the hemp fabric. The high-velocity impact test was performed by firing a hemispherical projectile on the proposed composites at a velocity range of 80 to 160 m/s. The effectiveness of diluted rubber matrix coating and rubber layer in terms of projectile velocity reduction, damage mechanism, absorption of the kinetic energy of composites, and the effect of different layer configurations on residual velocity have been presented and investigated. The results show that elastomer hardness significantly affects the ballistic performance of flexible composites. Also, by examining the position of hemp fabric and rubber layers in the arrangement of layers, it is clear that better performance is obtained for a hybrid composite with hard layers on both sides of the impact face and a soft layer in the middle. The damage mechanism in composites with hard layers through small inlet and outlet diameters and more protective margins shows an excellent ability to absorb energy and subsequently reduce the residual velocity of projectiles.
Effects of Gamma, Electron-Beam, and X-ray Radiation on
EVA/EVOH/EVA Films
Authors: Fifield Leonard , Ni Yelin , Bisel Tucker , Hasan Md Kamrul , Li Donghui , Fuchs Witold , Cooley Scott , Nichols Larry , Pharr Matt , Dupuy Nathalie , Marque Sylvain , Murphy Mark , Pillai Suresh , Dorey Samuel 
Published: July 2023

Abstract
Many polymer-based medical devices are sterilized by gamma irradiation. To reduce the use of cobalt-60 gamma-ray sources, transition from gamma ray to alternative irradiation technologies was proposed, namely electron beam (e-beam) and X-ray. A major impediment for such a transition is the knowledge gap in material compatibility with the different radiation sources. In this study, multi-layer films consisting of ethylene vinyl acetate (EVA) and ethylene vinyl alcohol (EVOH) components were irradiated to target doses of 30, 45, and 60 kGy by gamma-ray, e-beam, and X-ray sources. Effects of irradiation were evaluated on 12 material properties, and statistical comparisons between gamma irradiation and alternative technologies were conducted using the two one-sided t-test (or “equivalence test”) and classic t-test. Melting temperature and UV absorbance below 300 nm showed dose dependencies, while other investigated properties such as discoloration and mechanical durability did not change with dose up to 60 kGy. Based on these results, there is no material compatibility issue associated with the transition from gamma to e-beam or to X-ray as source of sterilization radiation of the studied multi-layer film.
An Analysis of the Mechanisms of Public Trust on Environmental Risk Response Behavior: Evidence from China
Authors: Lan Lan , Huang Tianjing , Du Yanqiang , Bao Cunkuan 
Published: July 2023

Abstract
The public's environmental risk coping behaviors affects the effectiveness of environmental risk management. This paper uses a structural equation model (SEM) to explore the mechanisms of public trust in governments and enterprises on different types of environmental risk coping behaviors (collaborative and confrontational behaviors) by using the residents, who live around the industrial area J and the waste incineration plant Q in city A in China, as the study population. This research adopts the theory of planned behavior (TPB) and some additional constructs (risk perception, interaction satisfaction) in the empirical tests to predict behavioral choices. The results show that public trust in governments has a positive influence on the intention to collaborate, and a lower level of public trust in governments and enterprises enhances the intention to adopt confrontational behaviors. Public trust in governments and enterprises can also indirectly influence the intention to collaborate through subjective norms, attitudes, and perceived behavioral control. Public trust in governments and enterprises can also influence the intention to confront through perceived behavioral control. The intention to confront is related to confrontational behaviors, but the intention to collaborate may not necessarily lead to collaborative behavior. Risk perception is not directly related to trust and the intention to collaborate, but risk perception and trust can alone influence to intention to confront. The reason for the public to adopt collaborative behavior is not that they perceive high risk, but that a high level of trust in the governments can increase the level of willingness to adopt collaborative behaviors. Government credibility plays an important role in guiding public risk coping behaviors. The findings of the study provide policy recommendations for guiding the public’s environmental risk coping behaviors.
Herbal medicine Huazhuo Tiaozhi granule ameliorates dyslipidemia via regulating DDX17 lactylation and miR-155-5p biogenesis
Authors: Yin Xiangjun , Li Min , Wang Yongzhi , Zhao Guifang , Yang Tao , Zhang Yuqing , Guo Jianbo , Meng Tiantian , Du Ruolin , Li Honglin , Wang Zhe , Zhang Jian , He Qingyong 
Published: July 2023

Abstract
Background
Huazhuo Tiaozhi granule (HTG) is a herbal medicine prescription, which is widely used in clinical practice for hypolipidemic effect. However, the molecular mechanism in treating dyslipidemia has not been well elucidated.
Results
In the clinical trial, a significant reduction in the levels of TC and LDL-C was observed in serum of dyslipidemia patients after HTG treatment without disruption of the levels of AST, ALT, BUN and Cr. Dyslipidemia rat model was induced by high-fat diet and treated with Xuezhikang (0.14g/kg/d) and HTG (9.33g crude herb/kg/d) by gavage, respectively for 8 weeks. The body weight and liver index were markedly downregulated in dyslipidemia rats after the treatment of Xuezhikang and HTG. HTG markedly ameliorated hyperlipidemia by significantly decreasing the levels of TC and LDL-C in serum and hepatic lipid accumulation. In vitro, lipid accumulation in L02 cells was alleviated after 20% HTG medicated serum treatment. Moreover, HTG sustains glycolytic rate analyzed by Seahorse assay. However, high lactylation was observed in a total of 198 proteins including RNA binding protein DDX17(K121) lactylation, HDAC1 (K412, K438), H2B (K6) and H4(K80) lactylation, which inhibited the biogenesis of miR-155-5p in vitro.
Conclusions
This study demonstrates that HTG is an effective and safe formula in treating dyslipidemia, which promoted lactylation level in hepatocytes resulting in retardation of miR-155-5p biogenesis.
Studying Importance of Charge Noise and Measurement Basis for Spin Qubit in Quantum Dot
Authors: Joshi Abhijeet 
Published: July 2023

Abstract
Quantum computation has evolved from a mere word proposed by Richard Feynman in 1980 to a physical reality in 2023. Semiconductor quantum dot spin qubit can hold 106 qubits on area of 1 cm2,clearly indicating a promising candidate for a scalable quantum computer. However, the platform has not scaled up because of lack of understanding of physics of system and noise. Here Lindblad master equation is used to understand the dynamics of charge noise and qubit. The phenomena of Quantum Collapse to a basis state and its physical implications have raised many fundamental questions in last 50 years. Nevertheless, there has not been much discussion in quantum computing community about what choice of basis can be the best to measure a qubit. In this article it is shown that how measuring different spin component of a quantum state provides different coherence time. The article provides a motivation for experimentalist to look into qubit measurement with ability to measure it in arbitrary basis.