bluuebunny/crossref_metadata_2025_split huggingface dataset:
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease
Authors: Serrano-Pozo Alberto , Li Zhaozhi , Woodbury Maya , Muñoz-Castro Clara , Watcher Astrid , Jayakumar Rojashree , Bryant Annie , Noori Ayush , Welikovitch Lindsay , Hu Miwei , Zhao Karen , Liao Fan , Lin Gen , Pastika Timothy , Tamm Joseph ,   Aicha Abdourahman4, Kwon Taekyung , Bennett Rachel , Talanian Robert , Biber Knut , Karran Erik , Hyman Bradley , Das Sudeshna 
Published: December 2022

Abstract

Astrocytes play a critical role in brain homeostasis and normal functions but their changes along the spatiotemporal progression of Alzheimer’s disease (AD) neuropathology remain largely unknown. Here we performed single-nucleus RNA-sequencing on brain regions along the stereotypical progression of AD pathology from donors ranging the entire normal aging-AD continuum comprising 628,943 astrocyte nuclei from 32 donors across 5 brain regions. We discovered temporal gene-expression-trajectories with gene sets differentially activated at various disease stages. Surprisingly, a gene set enriched in proteostasis and energy metabolism, was upregulated in late-stage but unexpectedly returned to baseline levels in end-stage, suggesting exhaustion of response in “burnt-out” astrocytes. The spatial gene-expression-trajectories revealed that astrocytic genes of tripartite synapses are dysregulated in parallel to the stereotypical progression of tangle pathology across regions. We identified astrocyte heterogeneity across brain regions with a continuum from homeostatic to reactive cells through “intermediate” transitional states. These findings suggest complex astrocytic dysfunction in AD neurodegeneration.
Efficacy and Safety of Aripiprazole in Borderline Personality Disorder: A Systematic Review
Authors: Jiménez Glauco Valdivieso , Pino-Zavaleta Dennis Anthony , Campos-Rodriguez Susan K. , Ortiz-Saavedra Brando , Fernández María F. , Benites-Zapata Vicente Aleixandre 
Published: December 2022

Abstract

Introduction
Aripiprazole is an atypical antipsychotic drug, and its use in the treatment of borderline personality disorder remains controversial. We aimed to determine the efficacy and safety of aripiprazole in patients diagnosed with borderline personality disorder.
Methods
The protocol was registered in PROSPERO (CRD42021256647) on July 2, 2021. PubMed, Scopus, Web of Science, Ovid-Medline, Embase, PsycINFO, and Cochrane (CENTRAL) were searched, without restriction by language or publication date. Furthermore, we searched ClinicalTrials.gov trial registries and the WHO International Clinical Trials Registry Platform. The inclusion criteria were randomized clinical trials including adult patients (> 18 years) diagnosed with borderline personality disorder according to the Diagnostic and Statistical Manual of Mental Disorders criteria. The quality of the included studies was determined using the Cochrane risk-of-bias for randomized trials (RoB-2) tool.
Results
We included two randomized clinical trials published in three articles. Among these, 76 patients were diagnosed with borderline personality disorder, with 38, 12, and 26 assigned to the aripiprazole, olanzapine, and placebo groups, respectively. The majority of patients were women (88.16%), with an age range of 22.1–28.14 years. Aripiprazole was shown to reduce psychiatric symptoms (obsessive–compulsive behavior, insecurity, depression, anxiety, aggressiveness/hostility, phobic anxiety, paranoid thinking, psychoticism, and somatization), anxiety, depression, anger, hostility, and clinical severity. The adverse effects included headache, insomnia, restlessness, tremor, and akathisia. In both studies, the risk of bias was high, which is somewhat concerning.
Conclusions
Aripiprazole has shown promising results in the treatment of patients with borderline personality disorder. More randomized clinical trials are required.
IoT Based Intrusion Detection System for Healthcare Using RNNBiLSTM Deep Learning Strategy with Custom Features
Authors: JEYANTHI D.V. , Indrani B. 
Published: December 2022

Abstract

Internet of Things (IoT) devices exchange information directly between devices. They are more prone to vulnerability because of the design of the network layer in its architecture and also connected to the internet 24X7. IoT-based smart healthcare devices like patient monitoring cameras in hospital create life-saving data that must be shielded from intruders. Effective intrusion detection is required to safeguard sensitive private data before assault takes place due to the humongous data created by the IoT. This work proposes a 5-layered framework to find intrusion in large datasets. This work uses constructing new custom features to increase the learning rate and to reduce imperceptions during learning by the machine model. The proposed ACAAS algorithm obtains significant features and Recurrent Neural Networks with Long Short-Term Memory in both directions (RNNBiLSTM) is used to identify the assault to optimize the prediction performance accuracy by using the IoTID20 dataset to protect IoT networks. The experiment results provided Accuracy Rate of 99.16%, Error Rate of 0.008371%, Sensitivity Ratio of 99.89% and Specificity Ratio of 98.203% for IoTID20 with custom features using RNNBiLSTM. The obtained high accuracy rate shows the effectiveness of the system in protecting the network from intruders.
All-green Cellulose acetate/corn-cob Composite Membrane Filter with Combative Dye and Heavy Metal Adsorption Property
Authors: R Aswathy N , Sen Rituparna , Mongaraj Snehashree , S Sudha G , Mohapatra Aswini Kumar 
Published: December 2022

Abstract

From ancient times water bodies witnessed expel of a large number of pollutants and heavy metals from the nearest industries. To alleviate this concern wastewater from all industrial sectors requires treatment before discharging into natural water streams. Inspired by the natural adsorbent ‘corn-cob’ a novel all-green corn-cob/cellulose acetate (MCAPCB) composite membrane filter has been developed. The corn-cob, a food waste obtained after the consumption of corn acts as a filler as well as an adsorbent in the cellulose acetate membrane (MCA). The corn cob powder (PCB) and the alkali/hydrogen peroxide treated corn cob powder (TPCB) were incorporated into the MCA at various compositions and comparative dye adsorption capacities were analyzed. It was observed that 20 % PCB can be incorporated into the cellulose matrix without affecting the flexibility of the membrane. 0.5 grams of 20% TPCB incorporated CA membrane (MCATPCB20) achieved the highest methylene blue adsorption performance up to 97.46. 20% PCB incorporated CA membrane (MCAPCB20) exhibited adsorption of methylene blue up to 80.15% from the water. The adsorption efficiency of MCATPCB20 has been enhanced due to the increase in carboxyl content after the bleaching of PCB. The atomic absorption spectroscopy (AAS) and inductively coupled plasma spectroscopy (ICP-MS) studies of feed and filtrate solutions after microfiltration through MCATPCB20 proved that the developed films can be harnessed into an excellent material for cadmium (Cd) and lead (Pb) heavy metal adsorption. These results reveal that MCATPCB is a green, sustainable, effective, and efficient filter system for water purification.
A delayed ovulation of Progestin-Primed Ovarian Stimulation (PPOS) by down-regulating the LHCGR/PGR pathway
Authors: Xie Yating , Guo Wenya , Shen Xi , Yu Weina , Kuang Yanping , Chen Qiuju , Long Hui , Lyu Qifeng , Wang Li 
Published: December 2022

Abstract
PPOS as a new clinic ovulation stimulation protocol, its role in ovulation and regulatory mechanism is not clear. The clinical PPOS protocol was simulated in mice, and it had a delayed ovulation than the control group at 12.5 hours after hCG trigger. The suppressed LH level of PPOS group led to the reduced expression of LHCGR on the preovulatory follicles before trigger, and significantly decreased the following progesterone synthesis, blood progesterone level and progesterone-receptor (PGR) expression within 4-6 hours after hCG trigger. Furthermore, the important ovulatory genes regulated by PGR including ADAMTS1, VEGF-A and EDN2 were downregulated in the PPOS group, ultimately delaying the ovulation. Meanwhile, the distribution of ovulation trigger–OPU time intervals with oocyte retrieval rate (>70%) and mature oocyte rate (>80%) in patients using PPOS also indirectly indicate the delayed ovulation. This research provides the crucial evidence for patients using PPOS when arranging the OPU time interval.
What parts of “incident reporting culture” can predict nurses' willingness to report errors?
Authors: Hajihosseini Fatemeh , Mousazadeh Noushin , Nazari Roghieh , Nia Hamid Sharif 
Published: December 2022

Abstract
Background
The presence of errors is still an undeniable fact in health systems. Error reporting is necessary to analyze the causes and prevent their recurrence. Despite the efforts of health organizations to promote the culture of error reporting, the reporting of errors is still not at the desired level. This study was conducted to determine parts of the culture of incident reporting that can predict the willingness of nurses to report errors.
Methods
This cross-sectional study was conducted in 2021. Sampling was conducted by census method and 251 nurses who had at least one year of experience in general wards participated in it. They were clinician nurses working in three hospitals in northern Iran. A self-reporting questionnaire was used to collect data. To analyze the data, descriptive and analytical statistics were used.
Results
Two dimensions of error reporting culture, including learning from errors (B = 0.234, CI = 0.380 to 0.088) and error management (B = 0.029, CI = 0.013 to 0.235) can predict the willingness to report errors in nurses. Only marital status had a significant relationship with the willingness to report errors in nurses (P < 0.001).
Conclusions
Increasing the willingness of nurses to report their errors requires the promotion of "learning from error" and "error management" in the culture of incident reporting. It is recommended that nursing managers and supervisors focus more on the culture of incident reporting, especially these two aspects.
Experimental and Theoretical Investigation of the Mechanisms of Drying During CO2 injection into Saline Reservoirs
Authors: Sokama-Neuyam Yen Adams , Yu Muhammad Aslam Md , Owusu Shadrack Kofi , Darkwah-Owusu Victor , Turkson Joshua Nsiah , Otchere Adwoa Sampongmaa , Ursin Jann Rune 
Published: December 2022

Abstract

A viable CO2 storage resource must have sufficient storage capacity, reliable containment efficiency and adequate well injectivity. Deep saline formations stand out in terms of storage capacity and containment efficiency. However, formation brine dry-out and salt precipitation in the near well region could impair CO2 injectivity in deep saline reservoirs, thus reducing their potential for CO2 storage. Core-flood experiments and analytical modelling were used to investigate various mechanisms of external and internal salt precipitation. Particularly, the impact of the extension of the dry-out region on CO2 injectivity was investigated. It was found that, for high permeability rocks, injection of CO2 at relatively low injection rates could result in salt cake deposition at the injection inlet especially under high salinity conditions. It was also found that extension of the dry-out region does not have significant impact on CO2 injectivity. Although the magnitude of CO2 injectivity impairment increased more than two-fold when initial brine salinity doubled, the development of CO2 injectivity was found to be independent of initial brine salinity. We have shown that the bundle-of-tubes model could provide useful insight into the process of brine vaporization and salt deposition in the dry-out region during CO2 injection. This work provides vital understanding of the effect of salt precipitation on CO2 injectivity.
Influence of the Sun on Water.
Dependence on Geometry of Solution and its Position in Space.
Authors: Shevchenko Igor 
Published: December 2022

Abstract
The variations of solar activity and distribution of solar energy due to the rotation of the Earth around its axis and around the Sun exert a strong influence on the self-organization of water molecules. As a result, the chemical reactivity of water clusters in hydrolytic reactions depends on geographic latitude and displays diurnal, very large annual variations, and is also modulated by the 11-year cycles of solar activity. This phenomenon may be well accounted for by the decomposition of water clusters by muons which are constantly generated in the upper atmosphere by the solar wind. Since the muon flux is anisotropic, its influence depends on the area of a reaction solution which is affected by muons. For this reason, the reaction rate is highly dependent on the geometry of the solution and its position in space. For example, the difference in the rate of hydrolysis of triethyl phosphite in three 5-mm NMR tubes directed North-South, East-West and Vertically can be very large. The rate ratios between the tubes vary greatly during the day, along with the direction of the muon flux. The rate of hydrolysis in the East-West tube displays the largest daily fluctuations depending on the position of the Sun in the sky. Thus, this chemical process can be used to determine solar activity at different locations on the Earth and track changes in the direction of the muon flux.
Confounding and Confounding Control
Authors: Ren Shaolong , Zhao Genming 
Published: December 2022

Abstract

Currently, the classical, counterfactual, and structural confounding definitions, are simultaneously used in teaching or practice context of epidemiology. Despite the resemblance, the three definitions are different in many aspects. A unified theory of confounding and confounding control has not been established. At the same time, the distinction between several confounding-related concepts is not clear-cut. Inspired by the structural causal model, this paper puts forwards an improved confounding definition to unify previous confounding definitions. The improved definition defines confounding as the association between exposure and the risk factor for the outcome, which cannot be interpreted by the causal effect of exposure on the risk factor. In so doing, confounding control methods is derived naturally, and several confusing confounding-related concepts is distinguished clearly.
Two level deacidification mathematical model for the description of transport of solid alkaline particles and diffusion of ions in a treated acid paper
Authors: Danielik Vladimír , Králik Milan , Ambrová Marta , Jurišová Jana , Jablonský Michal , Vizárová Katarína , Vajová Izabela 
Published: December 2022

Abstract

The industrial progress in papermaking in the early 19th century led to the technologies resulting in more acidic papers, which was caused mainly by exploitation of alum (KAl(SO4)2) and rosin. Papers prepared by such technologies have degraded more quickly. From the 1930 various deacidification and preservation processes with basic agents have been developed. The most widespread deacidification process is with the aerosol (spray system) consisting of microscale particles MgO and perfluoroheptane (PFH) as a carrier (the so-called Bookkeeper process). The shortcomings of this process are low dissolution of solid MgO particles and transport to the interior of acidic paper. We have developed a theoretical two-level model of the Bookkeeper process suitable for prediction of deacidification extent. The model involves both the dissolution/reaction of the solid particles and transport of solvated ions and solid particles inside the bulk of paper. The developed model coincides with the results of the performed deacidification experiment. The model is also in good agreement with the Lucas-Washburn equation which is usually used for description of the penetration of a deacidifying agent into the paper.
Attributing Recent Variability in the Subpolar AMOC to Surface Buoyancy Forcing
Authors: Marris Charlotte , Marsh Robert 
Published: December 2022

Abstract
Variability in the Atlantic Meridional Overturning Circulation (AMOC) on interannual to multidecadal timescales can primarily be linked to the strength of deep-water formation in the Subpolar North Atlantic, where surface buoyancy forcing transforms light surface waters to the dense waters of the southward-flowing lower-limb of the AMOC. In a water mass transformation (WMT) framework, fields of surface density and surface density flux from the GODAS ocean reanalysis are used to construct the surface-forced overturning circulation (SFOC) streamfunction for the Subpolar North Atlantic (48-65°N), in an operational assimilation over 1980-2020. Computed and plotted in latitude-density space, the SFOC reconstruction compares favourably with the corresponding AMOC, computed from GODAS currents. To further partition dense waters contributing to the AMOC, the SFOC is longitudinally partitioned into an East component, comprising the Irminger/Iceland basins, and a West component, comprising the Labrador Sea. Interannual and multidecadal changes in the dominant location of deep-water formation in the Subpolar North Atlantic are thus elucidated. The analysis provides transport estimates complementary to those obtained with observations from the RAPID array since 2004, and OSNAP array since 2014, revealing that recent (post-2014) domination of overturning in the Eastern Subpolar Gyre may be transient.
Distribution, source identification, and ecological risk of PAHs in a large river- reservoir system
Authors: Zhang Hongzhi , Cui Kangping , Hassan Muhammad , Guo Zhi , Chen Yihan 
Published: December 2022

Abstract

Rivers and their reservoirs form a connected river-reservoir system that plays an important role in regulating the water environment. However, the distribution and potential environmental behaviour of polycyclic aromatic hydrocarbons (PAHs) in the river-reservoir system are scarce. This study focused on the occurrence, distribution and risk assessment of PAHs in a river-reservoir system based in the Dongjiang river source area. The concentration of Σ16PAHs in the water phase of the river-reservoir system was 102.2-407.6 ng/L and at a low level, with the main monomer being naphthalene (Nap). The main pollution source was dominated by a mixture of charcoal, coal and gasoline combustion. The proportion of gasoline and diesel combustion in the reservoir system was higher than the river system. In contrast, the occurrence level of Σ16PAHs in the reservoir system was relatively higher than the river. On the time scale, the levels of Nap were greatly enhanced in the spring, which might be correlated with its abundant input of stormwater runoff. The composition of the PAHs remained stable during the transition from river to reservoir, suggesting their durability and stability in the aquatic environment. Redundancy analysis indicated that temperature, NO3-, and NH4+ could impact the PAHs content. In general, the environmental risk of PAHs in the aqueous phase was at moderate risk and low health risk, with no effect on the safety of drinking water.
The mRNA vaccine BNT162b2 demonstrates impaired TH1 immunogenicity in human elders in vitro and aged mice in vivo
Authors: Brook Byron , Fatou Benoit , Checkervarty Abhinav , Barman Soumik , Sweitzer Cali , Bosco Anna-Nicole , Sherman Amy , Baden Lindsey (R) , Morrocchi Elena , Sanchez-Schmitz Guzman , Palma Paolo , Nanishi Etsuro , O'Meara Timothy , McGrath Marisa , Frieman Matthew , Soni Dheeraj , Haren Simon van , Ozonoff Al , Diray-Arce Joann , Steen Hanno , Dowling David , Levy Ofer 
Published: December 2022

Abstract
mRNA vaccines have been key to addressing the SARS-CoV-2 pandemic but have impaired immunogenicity and durability in vulnerable older populations. We evaluated the mRNA vaccine BNT162b2 in human in vitro whole blood assays with supernatants from adult (18-50 years) and elder (≥60 years) participants measured by mass spectrometry and proximity extension assay proteomics. BNT162b2 induced increased expression of soluble proteins in adult blood (e.g., C1S, PSMC6, CPN1), but demonstrated reduced proteins in elder blood (e.g., TPM4, APOF, APOC2, CPN1, and PI16), including 30-85% lower induction of TH1-polarizing cytokines and chemokines (e.g., IFNγ, and CXCL10). Elder TH1 impairment was validated in mice in vivo and associated with impaired humoral and cellular immunogenicity. Our study demonstrates the utility of a human in vitro platform to model age-specific mRNA vaccine activity, highlights impaired TH1 immunogenicity in older adults, and provides rationale for developing enhanced mRNA vaccines with greater immunogenicity in vulnerable populations.
Ground state solutions for a class of fractional Kirchhoff-Choquard equations
Authors: yang jie , liu lintao , chen haibo 
Published: December 2022

Abstract
Note: Please see pdf for full abstract with equations.
We study the following fractional Kirchhoff-Choquard equation
(a + b∫RN |(−Δ)s/2u|2dx)(−Δ)su + V(x)u = (Iμ ∗ F(u))ƒ(u), in RN,
u ∈ Hs(RN),
where a, b are positive constants, N ≥ 3s, μ ∈ (N − 2s,N), s ∈ (0, 1), Iμ is the Riesz potential. Under certain assumptions on V and ƒ, combing a monotonicity trick and global compactness lemma, we prove that the equation has a ground state solution.
2000 Mathematics Subject Classification. 35R11, 49J35.
WITHDRAWN: The Impact of Innovative Human Resources Management on Organizational Performance: A Systematic Review
Authors: Dawsari Fahid ,   Najim Mukhtar1
Published: December 2022

Abstract

This study provides a brief overview of the research on novel approaches to HRM. When it comes to creative HRM, a review of 47 articles reveals three main schools of thought. HRM innovation is, at its most basic, just that. Another area of study is how human resource management handles novelty. Third, the term "innovative HRM" can be found in business studies of inventiveness. Each of these three methods is discussed, as well as their theoretical foundations. The note concludes with a discussion of the implications for future research and practice.
The role of thrombocytopenia in the clinical management of patients with liver cirrhosis: opinion of experts in therapeutic and surgical hepatology
Authors: Maevskaya M. V. , Bessonova E. N. , Geyvandova N. I. , Kitsenko E. A. , Korochanskaia N. V. , Morozov V. G. , Khoronko Y. V. 
Published: December 2022

Seven of the country’s leading experts in the field of therapeutic and surgical hepatology answer questions on this issue: how relevant is thrombocytopenia in patients with CLD for clinical practice, what is the average proportion of patients who need correction of thrombocytopenia before scheduled and emergency surgical/invasive interventions and how is thrombocytopenia correction performed. All experts are unanimous in the opinion that thrombocytopenia is most common at the stage of cirrhosis. Further, the experts discussed the issues of the total number of patients with CLD, the proportion of patients with thrombocytopenia at all, the proportion of patients with thrombocytopenia in need of surgical interventions, the experts were asked to provide schemes for correcting thrombocytopenia, which they use in their clinical practice. The focus of the experts’ attention was on the discussion of patients who have a platelet level of less than 50 000/µl and need scheduled surgical interventions / invasive procedures. All experts unanimously stratify these interventions according to the risk of hemorrhagic complications: high – more than 1.5%, low – less than 1.5%. The most common and available method for the correction of thrombocytopenia at present is platelet transfusion. Details of all this information, as well as statistical data, can be found in this article.