bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolutionary game of destination brand co‐construction with government involvement
Authors: Sun Yong , Wang Yalin , Liu Baoyin , Sun Zhongrui 
Published: January 2023

AbstractTo gain a competitive advantage in tourism, more and more regions are adopting destination branding as their necessary strategy, but destination branding is a quasi‐public good that is prone to market failure. It is very necessary to formulate appropriate incentive policies. To design appropriate incentives and optimise the mechanism of destination brand co‐construction, this paper constructs an evolutionary game model, considering local governments, tourist attractions operating enterprises and tourism service enterprises. The results show that brand co‐building cost has a negative impact and brand premium has a positive impact on tourism enterprise cooperation. The cooperation reward of local government has a positive impact, and the punishment of noncooperation has a positive impact on tourism enterprise cooperation, and the restraint effect of punishment measures is more significant. This paper discusses the incentives to promote destination brand co‐construction, which can provide enlightenment for policy formulation.
Minigene splicing assays reveal new insights into exonic variants of the SLC12A3 gene in Gitelman syndrome
Authors: Shi Xiaomeng , Wang Hong , Zhang Ruixiao , Liu Zhiying , Guo Wencong , Wang Sai , Liu Xuyan , Lang Yanhua , Bottillo Irene , Dong Bingzi , Shao Leping 
Published: January 2023

AbstractBackgroundGitelman syndrome (GS) is a type of salt‐losing tubular disease, most of which is caused by SLC12A3 gene variants, and missense variants account for the majority. Recently, the phenomenon of exon skipping, in which variants disrupt normal pre‐mRNA splicing, has been related to a variety of diseases. Therefore, we hypothesize that a certain proportion of SLC12A3 variants can result in disease via interfering with the normal splicing process.MethodsWe analyzed 342 previously presumed SLC12A3 missense variants using bioinformatics programs and identified candidate variants that may alter the splicing of pre‐mRNA through minigene assays.ResultsOur study revealed that, among ten candidate variants, six variants (c.602G>A, c.602G>T, c.1667C>T, c.1925G>A, c.2548G>C, and c.2549G>C) led to complete or incomplete exon skipping by affecting exonic splicing regulatory elements and/or disturbing canonical splice sites.ConclusionIt is worth mentioning that this is the largest study on pre‐mRNA splicing of SLC12A3 exonic variants. In addition, our study emphasizes the importance of detecting splicing function at the mRNA level in GS and indicates that minigene analysis is a valuable tool for splicing functional assays of variants in vitro.
Considerations for hyperpolarized 13C MR at reduced field: Comparing 1.5T versus 3T
Authors: Traechtler Julia , Fuetterer Maximilian , Albannay Mohammed M. , Hoh Tobias , Kozerke Sebastian 
Published: January 2023

PurposeIn contrast to conventional MR, signal‐to‐noise ratio (SNR) is not linearly dependent on field strength in hyperpolarized MR, as polarization is generated outside the MR system. Moreover, field inhomogeneity‐induced artifacts and other practical limitations associated with field strengths 3T are alleviated at lower fields. The potential of hyperpolarized C spectroscopy and imaging at 1.5T versus 3T is demonstrated in silico, in vitro, and in vivo for applications on clinical MR systems.Theory and MethodsTheoretical noise and SNR behavior at different field strengths are investigated based on simulations. A thorough field comparison between 1.5T and 3T is performed using thermal and hyperpolarized C spectroscopy and imaging. Cardiac in vivo data is obtained in pigs using hyperpolarized [1‐C]pyruvate spectroscopy and imaging at 1.5T and 3T.ResultsBased on theoretical considerations and simulations, the SNR of hyperpolarized MR at identical acquisition bandwidths is independent of the field strength for typical coil setups, while adaptively changing the acquisition bandwidth proportional to the static magnetic field allows for net SNR gains of up to 40% at 1.5T compared to 3T. In vitro C data verified these considerations with less than 7% deviation. In vivo feasibility of hyperpolarized [1‐C]pyruvate dynamic metabolic spectroscopy and imaging at 1.5T is demonstrated in the pig heart with comparable SNR between 1.5T and 3T while B artifacts are noticeably reduced at 1.5T.ConclusionHyperpolarized C MR at lower field strengths is favorable in terms of SNR and off‐resonance effects, which makes 1.5T a promising alternative to 3T, especially for clinical cardiac metabolic imaging.
A two‐grid discontinuous Galerkin method for an incompressible miscible displacement problem
Authors: Yang Jiming , Zhou Jing , Su Yifan 
Published: January 2023

AbstractAn incompressible miscible displacement problem in porous media is studied. A two‐grid algorithm based on an interior penalty discontinuous Galerkin method is proposed. With this algorithm, solving a nonlinear system on the discontinuous finite element space is reduced to solving a nonlinear problem on a coarse grid and a linear problem on a fine grid. The error estimate for the concentration in H1‐norm and the error estimate for the velocity in L2‐norm are obtained. The numerical experiments are provided to confirm our theoretical analysis.
Superconvergence analysis of a conservative mixed finite element method for the nonlinear Klein–Gordon–Schrödinger equations
Authors: Shi Dongyang , Zhang Houchao 
Published: January 2023

AbstractIn this paper, a linearized mass and energy conservative mixed finite element method (MFEM) is proposed for solving the nonlinear Klein–Gordon–Schrödinger equations. Optimal error estimates without grid‐ratio condition are derived by some rigorous analysis and an error splitting technique, that is, one is the temporal error which is only τ‐dependent and the other is the spatial error which is only h‐dependent. Furthermore, the superclose results are obtained by using the idea of combination of interpolation and projection. Besides, a so‐called “lifting” approach also play an important role to obtain the superclose results. With the above achievements, the global superconvergent properties are deduced through the interpolated post processing operators. Finally, three numerical examples are given to validate the convergence order, unconditional stability, mass, and energy conservation.
Robust exponential stabilization of stochastic coupled T‐S fuzzy complex networks subject to state‐dependent impulsive control
Authors: Cao Zhengran , Li Chuandong , Zhang Xiaoyu , Yang Xujun 
Published: January 2023

AbstractThe problem of robust exponential stabilization for T‐S fuzzy stochastic dynamical networks (T‐S FSDNs) based on the state‐dependent impulsive controller is investigated in the paper. Using B‐equivalence approach, some sufficient conditions are provided such that every solution of considered systems intersects each impulsive surface exactly once. Then, combining with the inequality technique and comparison principle, some meaningful sufficient criteria are obtained to ensure the mean square stability of T‐S fuzzy stochastic dynamical networks. Compared to related results, the results obtained in the paper are low conservatism and easy to verify. Finally, two numerical simulations based on Rssler's system and Lorenz system show the effectiveness of the obtained theoretical results.
Investigation on physical properties of nanobubbled water using gas water circulation method: Environmental perspective
Authors: Joy Nivin , Senthilkumar Gnanamani , Logesh Periya Gurusamy , Hariharan Ravi 
Published: January 2023

AbstractThe objective of this present study is to examine the effect of nanobubbles on the physical properties improvement in the chosen water sample. So far, the research outcomes stated that the physical properties could be enhanced by addition of nanoparticles, but very few studies were performed with nanobubbles. The unique properties of nanobubbles (70–120 nanometers) explain their use in a wide range of engineering fields. Simple method for producing nanobubbles in a variety of aqueous solutions along with examples of their use is outlined in this work. Global environmental issues, including the deterioration and depletion of water supply are driving today's need for water treatment technology. As a solution, the use of micro‐ and nano‐bubble (MNB) technologies in wastewater treatment has evolved. This page discuss the fundamentals of water treatment research, including their stability of bubbles, manufacturing processes, and chemical and physical features.
Essential trace elements in the African spider plant (Cleome gynandra). A case study in Molo Ward, Nakuru, Kenya
Authors: Rotich Nelson K. , Gatari Michael J. , Kareru Patrick , Boman Johan 
Published: January 2023

AbstractIn Kenya, cases of malnutrition and nutritionally related ailments have been on the rise. This calls for the search for food crops with vital trace elements. The aim of the current study was to use energy dispersive X‐ray fluorescence spectroscopy (EDXRF) to determine the concentrations of Zn, Fe, Cu, and Mn in the stems and leaves of the African spider plant (Cleome gynandra) in the context of nutrition. Stems and leaves of the African spider plant grown in the highland and in the lowland of Molo Ward, Nakuru, Kenya, were found to contain total available Zn in the range of 140 ± 50 to 230 ± 60 mg/kg, Fe in the range of 2200 ± 700 to 3900 ± 1700 mg/kg, Cu at 13 ± 3 to 16 ± 5 mg/kg, and Mn at 380 ± 120 to 400 ± 140 mg/kg. There was no significant difference in the average concentrations of the trace elements in the leaves and stems of the African spider plant from the lowland and highland regions of Molo Ward (p > 0.05). The concentrations of Zn, Fe, Cu, and Mn in the African spider plants is high enough to make it a nutritious traditional vegetable. Therefore, farmers should be encouraged and empowered to grow more vegetables.
Emotional Expression in Children’s Drawings of God
Authors: Jolley Richard P. , Dessart Grégory 
Published: January 2023

AbstractExperimental psychological research on the expressive aspects of children’s drawings has grown considerably in the last 40 years. It has reported consistently that children use the same expressive techniques as artists, despite varying opinions on how expressive drawing develops in childhood (e.g., U-shaped curve or age incremental patterns). The developmental findings have largely derived from drawing tasks that explicitly ask children to draw an emotion or mood (e.g. happy, sad, angry). Nevertheless, the pervasiveness of expression in children’s drawings is such that we might expect children to spontaneously communicate expressively in drawing tasks that do not specifically request mood. “Drawing God” is such an example due to the potential emotive aspects of the subject, both in terms of the “God Figure” and the potential representation of other subject matter in the drawing. With this in mind, this chapter sets forth two sets of analyses of over 500 children’s drawings from Switzerland, obtained from a sample of 6- to 16-year-olds. First, we report findings from a quantitative study based on artist ratings that the intensity (strength) and valence (negative to positive) of the emotional expression in the drawings varies according to gender and religiosity. Age was not a significant predictor of intensity and only weakly predicted valence. Second, we describe narrative themes derived from our own observations of the dataset, in which all themes consistently indicated the same expressive techniques reported in the psychological experimental literature. Furthermore, despite being asked only to “draw God”, the drawings displayed a wide variety of themes which can be presented as a narrative story of the Christian Gospel.
Natural and Supernatural Agents: Children’s Representations of Gods and Dead Entities
Authors: Tau Ramiro 
Published: January 2023

AbstractWhen children face the task of having to draw something related to human death, their drawings are based on imaginary, figurative and schematic resources. These representations usually reveal children’s resolution of two fundamental problems regarding the comprehension of death; (a) which type of entity dies with death? (b) what are the characteristics of the space of the dead? From child’s perspective, what dies with death, and the place of the dead, are regulated by a specific legality, different from the one prevailing in his daily life. The physical, biological and psychological principles that children recognize as necessary in everyday experience are cancelled, inverted or alternated with death. This subversion becomes evident in drawings and is analogous to the one found in children’s representations of deities, supernatural agents, and divine spaces. The cognitive and figurative correspondence between the attributes children confer to the dead, the gods and the spaces they inhabit are analysed and discussed using data from two exploratory studies conducted in Argentina, with children from agnostic, atheist and Christian families. We address three broad axes:what,whereandhowchildren draw dead and supernatural entities, highlighting the te Luoreda Lamas, 2001; ndency towards anthropomorphization, the inaccessibility of the places inhabited by these beings and the attribution of non-normal capacities.
Postinjury multiple organ failure in polytrauma: more frequent and potentially less deadly with less crystalloid
Authors: King Kate L. , Dewar David C. , Briggs Gabrielle D. , Jones Mark , Balogh Zsolt J. 
Published: January 2023

Abstract
Background
Recently, retrospective registry-based studies have reported the decreasing incidence and increasing mortality of postinjury multiple organ failure (MOF). We aimed to describe the current epidemiology of MOF following the introduction of haemostatic resuscitation.

Methods
A 10-year prospective cohort study was undertaken at a Level-1 Trauma Centre-based ending in December 2015. Inclusion criteria age ≥ 16 years, Injury Severity Score (ISS) > 15, Abbreviated Injury Scale (AIS) Head < 3 and survived > 48 h. Demographics, physiological and shock resuscitation parameters were collected. The primary outcome was MOF defined by a Denver Score > 3. Secondary outcomes: intensive care unit length of stay (ICU LOS), ventilation days and mortality.

Results
Three hundred and forty-seven patients met inclusion criteria (age 48 ± 20; ISS 30 ± 11, 248 (71%) were males and 23 (6.6%) patients died. The 74 (21%) MOF patients (maximum Denver Score: 5.5 ± 1.8; Duration; 5.6 ± 5.8 days) had higher ISS (32 ± 11 versus 29 ± 11) and were older (54 ± 19 versus 46 ± 20 years) than non-MOF patients. Mean daily Denver scores adjusted for age, sex, MOF and ISS did not change over time. Crystalloid usage decreased over the 10-year period (p value < 0.01) and PRBC increased (p value < 0.01). Baseline cumulative incidence of MOF at 28 days was 9% and competing risk analyses showed that incidence of MOF increased over time (subdistribution hazard ratio 1.14, 95% CI 1.04 to 1.23, p value < 0.01). Mortality risk showed no temporal change. ICU LOS increased over time (subdistribution hazard ratio 0.95, 95% CI 0.92 to 0.98, p value < 0.01). Ventilator days increased over time (subdistribution hazard ratio 0.94, 95% CI 0.9 to 0.97, p value < 0.01).

Conclusion
The epidemiology of MOF continues to evolve. Our prospective cohort suggests an ageing population with increasing incidence of MOF, particularly in males, with little changes in injury or shock parameters, who are being resuscitated with less crystalloids, stay longer on ICU without improvement in survival.
The use of an individualized intraoperative video shows no impact on the early postoperative clinical outcome after total knee arthroplasty: a prospective, randomized, controlled trial
Authors: Sadoghi Patrick , Listl Christoph , Lewis Jan , Reinbacher Patrick , Leithner Andreas , Hauer Georg 
Published: January 2023

Abstract
Purpose
The purpose of the study was to evaluate the potential of an intraoperatively recorded video shown to patients immediately postoperatively on early outcome after total knee arthroplasty (TKA). The hypothesis was that there is a beneficial outcome concerning range of motion (ROM) and patient-reported outcome due to enhanced trust into the artificial joint.

Methods
Seventy-three patients were randomly assigned 1:1 to two study groups in which they were either shown a video of their own postoperative range of motion or they were not. Clinically, the New Knee Society Score (nKSS) and ROM were evaluated and compared between the groups 6 weeks after surgery. Chi-square exact test, Kolmogorov–Smirnov test, Mann–Whitney U test, and the Wilcoxon signed rank test were used. Inter- and intra-class correlations were calculated for measurements of ROM.

Results
No clinically relevant differences were observed preoperatively and 6 weeks postoperatively between both groups in range of motion (ROM). All patients were showing a significantly improved clinical outcome 6 weeks after the procedure. Clinical scores showed statistically significant differences with respect to preoperative nKSS for satisfaction and statistically significant differences with respect to postoperative nKSS for function.

Conclusion
Showing a video filmed immediately after implantation of primary TKA had no significant effect on ROM and clinical outcome at 6 weeks. We believe that face-to-face verbal communication in combination with video-assisted education ensures that patients understand their artificial joint in the best possible way and will continue to use intraoperatively filmed videos to enhance patient engagement during postoperative rehabilitation.

Level of evidence
I.
Crystal structure and optical absorption spectra of LiCo(SO4)OH and its remarkable relationship to the Zn-Mn-silicate hodgkinsonite
Authors: Wildner Manfred , Giester Gerald 
Published: January 2023

AbstractCrystals of the compound LiCo(SO4)OH were synthesised at low-hydrothermal conditions, and the crystal structure was determined and refined from single crystal X-ray diffraction data. LiCo(SO4)OH crystallises monoclinic, space group P21/c, Z = 4, a = 9.586(2), b = 5.425(1), c = 7.317(1) Å, β = 109.65(1)°, V = 358.3 Å3, wR2 = 0.0485 (2215 unique reflections, 78 variables). The structure is built from chains of edge-sharing, quite strongly bond-length and -angle distorted Co(OH)3O3 octahedra (< Co–O > = 2.126 Å), which are further linked by common corners, hydrogen bonds, and by properly shaped SO4 tetrahedra (< S–O > = 1.476 Å) to sheets parallel (100). These sheets are connected to a three-dimensional framework by sharing corners with distorted LiO4 polyhedra (< Li–O > = 1.956 Å). Apart from the isotypic sulfates of Mn2+ and Fe2+, only the molybdate LiCd(MoO4)OH crystallises isostructural with LiCo(SO4)OH. However, a very close structural relationship exists with the rare mineral hodgkinsonite, Zn2Mn(SiO4)(OH)2, yielding crystal chemically very uncommon topological equivalents of Zn2+ ≡ S6+ and Si4+ ≡ Li+, aside from the expectable substitution Mn2+ ≡ Co2+. Polarised optical absorption spectra of LiCo(SO4)OH reveal that the dominating spin-allowed 4T1(P) band system of Co2+ (d7 configuration) is strongly split up and covers a prominent part (~ 15,500–24,500 cm−1) of the visible spectral range, in accordance with the significant distortion of the Co(OH)3O3 polyhedron. The spectra are interpreted in terms of the Superposition Model of crystal fields, yielding a new set of intrinsic and interelectronic repulsion parameters for Co2+.
Die Riesenzellangiitis des zentralen Nervensystems
Authors: Simader Elisabeth , Klotz Sigrid , Höftberger Romana , Bobacz Klaus 
Published: January 2023

ZusammenfassungDie Vaskulitis des zentralen Nervensystems (ZNS) ist eine schwierig zu diagnostizierende Erkrankung, die sich oft hinter unspezifischen Symptomen versteckt. Biomarker können bei der Diagnosefindung hilfreich sein, schließen aber bei Fehlen die Erkrankung nicht aus. Wir berichten über einen 36-jährigen Patienten, der sich klinisch mit Schwindel und langsam aggravierenden Kopfschmerzen präsentierte. Nach einem Sturz über eine Treppe wurde eine Magnetresonanztomographie (MRT) des Schädels durchgeführt, die eine Raumforderung (RF) parietookzipital und eine Kontrastmittelanreicherung der Gefäße zeigte. Da zunächst der Verdacht einer malignen Erkrankung im Raum stand, wurde eine Gehirnbiopsie durchgeführt, die eine Einwanderung von Entzündungszellen in die Gefäßwände mit Formierung von Riesenzellen ergab. Zunächst erhielt der Patient neben Glukokortikoiden eine Therapie mit Cyclophosphamid und konsekutiv Mycophenolat mofetil als Erhaltungstherapie. Darunter kam es anfänglich zu einer klinischen Verbesserung und Regredienz der Vaskulitiszeichen im MRT. Im weiteren Verlauf kam es jedoch zu einem flare-up, sodass eine Therapieumstellung auf einen Interleukin-6-Inhibitor erfolgte, wobei die Riesenzellinfiltrate die Grundlage für die Therapieentscheidung waren. Unglücklicherweise führte diese Medikation zu keiner Verbesserung der Symptomatik, weswegen der Patient letztlich eine Therapie mit einem Tumornekrosefaktor-α-Inhibitor (TNF-Inhibitor) erhielt. Damit besserten sich die Beschwerden des Patienten und die RF imponierte im Schädel-MRT regredient. Dieser Fall zeigt, dass bei jungen Patient:innen mit unspezifischen neurologischen Symptomen eine Vaskulitis differenzialdiagnostisch stets in Betracht gezogen werden muss.
Dormant cancer cells: programmed quiescence, senescence, or both?
Authors: Truskowski Kevin , Amend Sarah R. , Pienta Kenneth J. 
Published: January 2023

AbstractMetastasis is the overwhelming driver of cancer mortality, accounting for the majority of cancer deaths. Many patients present with metastatic relapse years after eradication of the primary lesion. Disseminated cancer cells can undergo a durable proliferative arrest and lie dormant in secondary tissues before reentering the cell cycle to seed these lethal relapses. This process of cancer cell dormancy remains poorly understood, largely due to difficulties in studying these dormant cells. In the face of these challenges, the application of knowledge from the cellular senescence and quiescence fields may help to guide future thinking on the study of dormant cancer cells. Both senescence and quiescence are common programs of proliferative arrest that are integral to tissue development and homeostasis. Despite phenotypic differences, these two states also share common characteristics, and both likely play a role in cancer dormancy and delayed metastatic relapse. Understanding the cell biology behind these states, their overlaps and unique characteristics is critical to our future understanding of dormant cancer cells, as these cells likely employ some of the same molecular programs to promote survival and dissemination. In this review, we highlight the biology underlying these non-proliferative states, relate this knowledge to what we currently know about dormant cancer cells, and discuss implications for future work toward targeting these elusive metastatic seeds.