bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding State Policies in Agriculture
Authors: Koc Mustafa 
Published: September 2023

<p> State policies have played a significant role in shaping the structure of agrarian economy in both advanced and under‐developed capitalist societies. The influence of the state over the rural sector is not simply confined to its agricultural policies but covers a large array of policies and actions that may have direct as well as indirect effects on the rural population. This paper deals with the factors that influence agricultural policies of the state in the specific case of state policies towards Oriental tobacco production in Turkey. </p>
Meta in Film and Television Series
Authors: Roche David 
Published: September 2023

“That’s so meta!” The emergence of the prefix-turned-adjective “meta” to describe media productions is, no doubt, symptomatic of an increasingly media-savvy audience; it has also drawn attention to the lack of scholarship on meta-phenomena in film and television studies. Meta in Film and Television Series aims to make up for this. Meta is defined as an intense form of reflexivity, that is characterized by its aboutness; meta-phenomena are not just an arsenal of devices but suppose an interpretive act and an active audience. Meta creates a framework with which to interrogate a work’s relationship to its production, reception, medium, forms, and the world, and to explore its potentials and limitations. Meta supports the intuition latent in the popular usage that meta-phenomena are deeply entangled, while demonstrating that analysis stills requires such concepts to make sense of them.
Assessing Intelligence
Authors: Lyons Sara 
Published: September 2023

How did Victorian novelists engage with the new theories of human intelligence that emerged from late nineteenth-century psychology and evolutionary science? Assessing Intelligence traces the genealogy of the modern concept of IQ. It examines how five writers – George Eliot, Thomas Hardy, Henry James, HG Wells and Virginia Woolf – used the bildungsroman, or the novel of education, to wrestle with the moral and political implications of the IQ model of intelligence and the fantasies of meritocracy it provoked. Drawing upon the work of Michel Foucault and Jacques Rancière, Sara Lyons argues that Victorian and Edwardian novelists were by turns complicit in the biopolitics of intelligence and sought radical ways to affirm the equality of minds.
Use of biogenic silver nanoparticles on the cathode to improve bioelectricity production in microbial fuel cells
Authors: Elkhrachy Ismail , Singh Vandana , Kumar Ankit , Roy Arpita , Abbas Mohamed , Gacem Amel , Alam Mir Waqas , Yadav Krishna Kumar , Verma Devvret , Jeon Byong-Hun , Park Hyun-Kyung 
Published: September 2023

To date, research on microbial fuel cells (MFCs) has. focused on the production of cost-effective, high-performance electrodes and catalysts. The present study focuses on the synthesis of silver nanoparticles (AgNPs) by Pseudomonas sp. and evaluates their role as an oxygen reduction reaction (ORR) catalyst in an MFC. Biogenic AgNPs were synthesized from Pseudomonas aeruginosa via facile hydrothermal synthesis. The physiochemical characterization of the biogenic AgNPs was conducted via scanning electron microscopy (SEM), X-ray diffraction (XRD), and UV-visible spectrum analysis. SEM micrographs showed a spherical cluster of AgNPs of 20–100 nm in size. The oxygen reduction reaction (ORR) ability of the biogenic AgNPs was studied using cyclic voltammetry (CV). The oxygen reduction peaks were observed at 0.43 V, 0.42 V, 0.410 V, and 0.39 V. Different concentrations of biogenic AgNPs (0.25–1.0 mg/cm2) were used as ORR catalysts at the cathode in the MFC. A steady increase in the power production was observed with increasing concentrations of biogenic AgNPs. Biogenic AgNPs loaded with 1.0 mg/cm2 exhibited the highest power density (PDmax) of 4.70 W/m3, which was approximately 26.30% higher than the PDmax of the sample loaded with 0.25 mg/cm2. The highest COD removal and Coulombic efficiency (CE) were also observed in biogenic AgNPs loaded with 1.0 mg/cm2 (83.8% and 11.7%, respectively). However, the opposite trend was observed in the internal resistance of the MFC. The lowest internal resistance was observed in a 1.0 mg/cm2 loading (87 Ω), which is attributed to the high oxygen reduction kinetics at the surface of the cathode by the biogenic AgNPs. The results of this study conclude that biogenic AgNPs are a cost-effective, high-performance ORR catalyst in MFCs.
Machine learning models for predicting the risk factor of carotid plaque in cardiovascular disease
Authors: Bin Chengling , Li Qin , Tang Jing , Dai Chaorong , Jiang Ting , Xie Xiufang , Qiu Min , Chen Lumiao , Yang Shaorong 
Published: September 2023

IntroductionCardiovascular disease (CVD) is a group of diseases involving the heart or blood vessels and represents a leading cause of death and disability worldwide. Carotid plaque is an important risk factor for CVD that can reflect the severity of atherosclerosis. Accordingly, developing a prediction model for carotid plaque formation is essential to assist in the early prevention and management of CVD.MethodsIn this study, eight machine learning algorithms were established, and their performance in predicting carotid plaque risk was compared. Physical examination data were collected from 4,659 patients and used for model training and validation. The eight predictive models based on machine learning algorithms were optimized using the above dataset and 10-fold cross-validation. The Shapley Additive Explanations (SHAP) tool was used to compute and visualize feature importance. Then, the performance of the models was evaluated according to the area under the receiver operating characteristic curve (AUC), feature importance, accuracy and specificity.ResultsThe experimental results indicated that the XGBoost algorithm outperformed the other machine learning algorithms, with an AUC, accuracy and specificity of 0.808, 0.749 and 0.762, respectively. Moreover, age, smoke, alcohol drink and BMI were the top four predictors of carotid plaque formation. It is feasible to predict carotid plaque risk using machine learning algorithms.ConclusionsThis study indicates that our models can be applied to routine chronic disease management procedures to enable more preemptive, broad-based screening for carotid plaque and improve the prognosis of CVD patients.
Cardiac magnetic resonance assessment of cardiac involvement in autoimmune diseases
Authors: Gulhane Avanti , Ordovas Karen 
Published: September 2023

Cardiac magnetic resonance (CMR) is emerging as the modality of choice to assess early cardiovascular involvement in patients with autoimmune rheumatic diseases (ARDs) that often has a silent presentation and may lead to changes in management. Besides being reproducible and accurate for functional and volumetric assessment, the strength of CMR is its unique ability to perform myocardial tissue characterization that allows the identification of inflammation, edema, and fibrosis. Several CMR biomarkers may provide prognostic information on the severity and progression of cardiovascular involvement in patients with ARDs. In addition, CMR may add value in assessing treatment response and identification of cardiotoxicity related to therapy with immunomodulators that are commonly used to treat these conditions. In this review, we aim to discuss the following objectives:
•Illustrate imaging findings of multi-parametric CMR approach in the diagnosis of cardiovascular involvement in various ARDs;•Review the CMR signatures for risk stratification, prognostication, and guiding treatment strategies in ARDs;•Describe the utility of routine and advanced CMR sequences in identifying cardiotoxicity related to immunomodulators and disease-modifying agents in ARDs;•Discuss the limitations of CMR, recent advances, current research gaps, and potential future developments in the field.
Case report: Recurrence of inflammatory cardiomyopathy detected by magnetocardiography
Authors: Suwalski Phillip , Golpour Ainoosh , Musigk Nicolas , Wilke Finn , Landmesser Ulf , Heidecker Bettina 
Published: September 2023

BackgroundThe diagnosis of inflammatory cardiomyopathies remains challenging. Life-threatening conditions such as acute coronary syndrome (ACS) always have to be considered as differential diagnoses due to similarities in presentation. Diagnostic methods for inflammatory cardiomyopathy include endomyocardial biopsy (EMB), cardiac magnetic resonance imaging (CMR), and positron emission tomography-computed tomography (PET-CT). We report a case in whom magnetocardiography (MCG) led to an initial diagnosis of inflammatory cardiomyopathy and in whom MCG was used for subsequent monitoring of treatment response under immunosuppression.Case presentationA 53-year-old man presented with two recurrent episodes of inflammatory cardiomyopathy within a 2-year period. The patient initially presented with reduced exercise capacity. Echocardiography revealed a moderately reduced left ventricular ejection fraction (LVEF 40%). Coronary angiography ruled out obstructive coronary artery disease (CAD) and an EMB was performed. The EMB revealed inflammatory cardiomyopathy without viral pathogens or replication. Moreover, we performed MCG, which confirmed a pathological Tbeg-Tmax vector of 0.108. We recently established a cutoff value of Tbeg-Tmax of 0.051 or greater for the diagnosis of inflammatory cardiomyopathy. Immunosuppressive therapy with prednisolone was initiated, resulting in clinical improvement and an LVEF increase from 40% to 45% within 1 month. Furthermore, the MCG vector improved to 0.036, which is considered normal based on our previous findings. The patient remained clinically stable for 23 months. During a routine follow-up, MCG revealed an abnormal Tbeg-Tmax vector of 0.069. The patient underwent additional testing including routine laboratory values, echocardiography (LVEF 35%), and PET-CT. PET-CT revealed increased metabolism in the myocardium—primarily in the lateral wall. Therapy with prednisolone and azathioprine was initiated and MCG was used to monitor the effect of immunosuppressive therapy.ConclusionIn addition to diagnostic screening, MCG has the potential to become a valuable method for surveillance monitoring of patients who have completed treatment for inflammatory cardiomyopathy. Furthermore, it could be used for treatment monitoring. While changes in the magnetic vector of the heart are not specific to inflammatory cardiomyopathy, as they may also occur in other types of cardiomyopathies, MCG offers a tool of broad and efficient diagnostic screening for cardiac pathologies without side effects.
Predicting formative feedback practices: improving learning and minimising a tendency to ignore feedback
Authors: Brown Gavin T. L. , Andersson Catarina , Winberg Mikael , Palm Torulf 
Published: September 2023

IntroductionTeacher conceptions of feedback ideally predict their feedback practices, but little robust evidence identifies which beliefs matter to practices. It is logical to presume that teacher conceptions of feedback would align with the policy framework of an educational jurisdiction. The Teacher Conceptions of Feedback (TCoF) inventory was developed in New Zealand which has a relatively low-stakes, formative policy framework.MethodsThis study surveyed 451 Swedish teachers working in Years 1-9, a policy context that prioritises teachers using multiple data sources to help students learn. The study used a translated version of the TCoF inventory, but isolated six items related to formative feedback practices from various factors.ResultsA six-factor TCoF was recovered (Praise, Improvement, Ignore, Required, PASA, and Timely), giving partial replication to the previous study. A well-fitting structural equation model showed formative practices were predicted by just two conceptions of feedback (i.e., feedback improves learning and students may ignore feedback).DiscussionThis study demonstrates that the TCoF inventory can be used to identify plausible relations from feedback beliefs to formative feedback practices.
Association of maternal thyroid peroxidase antibody during pregnancy with placental morphology and inflammatory and oxidative stress responses
Authors: Ru Xue , Yang Mengting , Teng Yuzhu , Han Yan , Hu Yabin , Wang Jianqing , Tao Fangbiao , Huang Kun 
Published: September 2023

BackgroundStudies suggest that thyroid peroxidase antibody (TPOAb) positivity exposure during pregnancy may contribute to changes in placental morphology and pathophysiology. However, little is known about the association of maternal TPOAb during pregnancy with placental morphology and cytokines. This study focuses on the effect of repeated measurements of maternal TPOAb during pregnancy on the placental morphology and cytokines.MethodsBased on Ma’anshan Birth Cohort (MABC) in China, maternal TPOAb levels were retrospectively detected in the first, second and third trimesters. Placental tissues were collected 30 minutes after childbirth, placental morphological indicators were obtained by immediate measurement and formula calculation, and cytokine mRNA expression was detected by real-time quantitative polymerase chain reaction (RT-qPCR) afterward. Generalized linear models and linear mixed models were analyzed for the relationships of maternal TPOAb in the first, second and third trimesters with placental indicators.ResultsTotally 2274 maternal-fetal pairs were included in the analysis of maternal TPOAb levels and placental morphology, and 2122 pairs were included in that of maternal TPOAb levels and placental cytokines. Maternal TPOAb levels in early pregnancy were negatively associated with placental length, thickness, volume, weight and disc eccentricity, while positively correlated with placental IL-6, TNF-α, CRP, CD68, MCP-1, IL-10, HO-1, HIF-1α and GRP78. In mid-pregnancy, maternal TPOAb levels were negatively correlated with placental length, width and area. In late pregnancy, maternal TPOAb levels were negatively correlated with placental length, area, volume and weight. Repeated measures analysis showed that maternal TPOAb positivity tended to increase placental TNF-α, CD68 and MCP-1 while decreasing placental length, width and area than TPOAb negativity. Repeated measures analysis showed that maternal TPOAb levels were positively correlated with placental IL-6, TNF-α, CD68, MCP-1, IL-10, HO-1, HIF-1α and GRP78, while negatively correlated with placental length, area, volume, weight, and disc eccentricity.ConclusionThere may be trimester-specific associations between maternal TPOAb levels and placental morphology and inflammatory and oxidative stress responses. The effect of maternal TPOAb levels on placental morphology is present throughout pregnancy. Early pregnancy may be the critical period for the association between maternal TPOAb levels and placental inflammatory and oxidative stress responses.
Next-generation sequencing improves precision medicine in hearing loss
Authors: Imizcoz T. , Prieto-Matos C. , Manrique-Huarte R. , Calavia D. , Huarte A. , Pruneda P. C. , Ordoñez G. R. , Cañada-Higueras E. , Patiño-García A. , Alkorta-Aranburu G. , Manrique Rodríguez M. 
Published: September 2023

Background: An early etiological diagnosis of hearing loss positively impacts children’s quality of life including language and cognitive development. Even though hearing loss associates with extremely high genetic and allelic heterogeneity, several studies have proven that Next-Generation Sequencing (NGS)-based gene panel testing significantly reduces the time between onset and diagnosis.Methods: In order to assess the clinical utility of our custom NGS GHELP panel, the prevalence of pathogenic single nucleotide variants, indels or copy number variants was assessed by sequencing 171 nuclear and 8 mitochondrial genes in 155 Spanish individuals with hearing loss.Results: A genetic diagnosis of hearing loss was achieved in 34% (52/155) of the individuals (5 out of 52 were syndromic). Among the diagnosed cases, 87% (45/52) and 12% (6/52) associated with autosomal recessive and dominant inheritance patterns respectively; remarkably, 2% (1/52) associated with mitochondrial inheritance pattern. Although the most frequently mutated genes in this cohort were consistent with those described in the literature (GJB2, OTOF or MYO7A), causative variants in less frequent genes such as TMC1, FGF3 or mitCOX1 were also identified. Moreover, 5% of the diagnosed cases (3/52) were associated with pathogenic copy number variants.Conclusion: The clinical utility of NGS panels that allows identification of different types of pathogenic variants–not only single nucleotide variants/indels in both nuclear and mitochondrial genes but also copy number variants–has been demonstrated to reduce the clinical diagnostic odyssey in hearing loss. Thus, clinical implementation of genomic strategies within the regular clinical practice, and, more significantly, within the newborn screening protocols, is warranted.
The effect of ions doping on the rheological properties of ferrite ferrofluids
Authors: Chen Fang , Zhang Jie , Liu Xiaobing , Yan Shengnan , Li Wangxu , Yan Zhaoqiang , Li Zhenggui 
Published: September 2023

A series of ferrite nanoparticles were synthesized via ion doping and then were coated by surfactant and dispersed in perfluorinated polyether oil (PFPE-oil), and the various ferrite ferrofluids were obtained. The scanning electron microscope was used to characterize the morphology of particles and the dispersed state of ferrofluid, energy-dispersive spectroscopy was used to study the chemical composition of particles, fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis were used to study the coated effect of PFPE-acids on particles, vibrating sample magnetometer was used to research the magnetization curves of ferrite particles, and the rheological property of the ferrite ferrofluids was studied by a rheometer. The results show that Zn2+, Mn2+/Zn2+, and Dy3+ ions were doped in the ferrite nanoparticles with a size less than 50 nm. The four kinds of ferrite nanoparticles have the characteristics of super-paramagnetic materials, and the M-T curves decrease with increasing temperature, while their decline rates are notably different. The ferrite particles are coated with PFPE acids chemically, and the ferrofluids have well dispersion stability. The rheological properties of the ferrite ferrofluids change with the variation of ion doping, magnetic field strength, temperature, etc. The magnetism and viscosity of ferrite ferrofluids are regularly affected by ion doping, and the results will have a great significance on basic research and related applications.
Occurrence of SARS-CoV-2 viremia is associated with genetic variants of genes related to COVID-19 pathogenesis
Authors: Roy-Vallejo Emilia , Fernández De Córdoba-Oñate Sara , Delgado-Wicke Pablo , Triguero-Martínez Ana , Montes Nuria , Carracedo-Rodríguez Rosa , Zurita-Cruz Nelly , Marcos-Jiménez Ana , Lamana Amalia , Galván-Román José María , Villapalos García Gonzalo , Zubiaur Pablo , Ciudad Marianela , Rabes Laura , Sanz Marta , Rodríguez Carlos , Villa Almudena , Rodríguez Jesús Álvarez , Marcos Celeste , Hernando Julia , Díaz-Fernández Paula , Abad Francisco , de los Santos Ignacio , Rodríguez Serrano Diego A. , García-Vicuña Rosario , Suárez Fernández Carmen , P. Gomariz Rosa , Muñoz-Calleja Cecilia , Fernández-Ruiz Elena , González-Álvaro Isidoro , Cardeñoso Laura ,   the PREDINMUN-COVID Group
Published: September 2023

IntroductionSARS-CoV-2 viral load has been related to COVID-19 severity. The main aim of this study was to evaluate the relationship between SARS-CoV-2 viremia and SNPs in genes previously studied by our group as predictors of COVID-19 severity.Materials and methodsRetrospective observational study including 340 patients hospitalized for COVID-19 in the University Hospital La Princesa between March 2020 and December 2021, with at least one viremia determination. Positive viremia was considered when viral load was above the quantifiable threshold (20 copies/ml). A total of 38 SNPs were genotyped. To study their association with viremia a multivariate logistic regression was performed.ResultsThe mean age of the studied population was 64.5 years (SD 16.6), 60.9% patients were male and 79.4% white non-Hispanic. Only 126 patients (37.1%) had at least one positive viremia. After adjustment by confounders, the presence of the minor alleles of rs2071746 (HMOX1; T/T genotype OR 9.9 p &lt; 0.0001), rs78958998 (probably associated with SERPING1 expression; A/T genotype OR 2.3, p = 0.04 and T/T genotype OR 12.9, p &lt; 0.0001), and rs713400 (eQTL for TMPRSS2; C/T + T/T genotype OR 1.86, p = 0.10) were associated with higher risk of viremia, whereas the minor alleles of rs11052877 (CD69; A/G genotype OR 0.5, p = 0.04 and G/G genotype OR 0.3, p = 0.01), rs2660 (OAS1; A/G genotype OR 0.6, p = 0.08), rs896 (VIPR1; T/T genotype OR 0.4, p = 0.02) and rs33980500 (TRAF3IP2; C/T + T/T genotype OR 0.3, p = 0.01) were associated with lower risk of viremia.ConclusionGenetic variants in HMOX1 (rs2071746), SERPING1 (rs78958998), TMPRSS2 (rs713400), CD69 (rs11052877), TRAF3IP2 (rs33980500), OAS1 (rs2660) and VIPR1 (rs896) could explain heterogeneity in SARS-CoV-2 viremia in our population.
Physical activity monitoring in Alzheimer’s disease during sport interventions: a multi-methodological perspective
Authors: David Shari , Hohenfeld Christian , Haberl Luisa , Pahl Jennifer , Costa Ana S. , Kilders Axel , Hildebrand Frank , Schulz Jörg B. , Reetz Kathrin , Haeger Alexa 
Published: September 2023

IntroductionAssessment methods for physical activity and fitness are of upmost importance due to the possible beneficial effect of physical conditioning on neurodegenerative diseases. The implementation of these methods can be challenging when examining elderly or cognitively impaired participants. In the presented study, we compared three different assessment methods for physical activity from the Dementia-MOVE trial, a 6-months intervention study on physical activity in Alzheimer’s disease. The aim was to determine the comparability of physical activity assessments in elderly participants with cognitive impairment due to Alzheimer’s disease.Material or methods38 participants (mean age 70 ± 7 years) with early-stage Alzheimer’s disease (mean MoCA 18.84 ± 4.87) were assessed with (1) fitness trackers for an average of 12 (± 6) days, (2) a written diary on daily activities and (3) a questionnaire on physical activity at three intervention timepoints. For comparison purposes, we present a transformation and harmonization method of the physical assessment output parameters: Metabolic equivalent of task (MET) scores, activity intensity minutes, calorie expenditure and moderate-to-vigorous physical activity (MVPA) scores were derived from all three modalities. The resulting parameters were compared for absolute differences, correlation, and their influence by possible mediating factors such as cognitive state and markers from cerebrospinal fluid.ResultsParticipants showed high acceptance and compliance to all three assessment methods. MET scores and MVPA from fitness trackers and diaries showed high overlap, whilst results from the questionnaire suggest that participants tended to overestimate their physical activity in the long-term retrospective assessment. All activity parameters were independent of the tested Alzheimer’s disease parameters, showing that not only fitness trackers, but also diaries can be successfully applied for physical activity assessment in a sample affected by early-stage Alzheimer’s disease.DiscussionOur results show that fitness trackers and physical activity diaries have the highest robustness, leading to a highly comparable estimation of physical activity in people with Alzheimer’s disease. As assessed parameters, it is recommendable to focus on MET, MVPA and on accelerometric sensor data such as step count, and less on activity calories and different activity intensities which are dependent on different variables and point to a lower reliability.