bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asking the classroom with technology: a systematic literature review
Authors: Alam Talha Mahboob , Stoica George Adrian , Özgöbek Özlem 
Published: January 2025

Abstract
Response technologies (RTs), also termed clickers or student response systems, have gained traction among researchers in classrooms in recent years. RTs encompass various interactive tools and technologies that are pivotal in modern educational settings. Numerous articles emphasize the effectiveness of RTs across multiple grades and courses. Existing literature reviews on the subject need a systematic review from a school classroom perspective. This article aims to present a systematic review of the literature on the effectiveness of RTs in school classrooms and highlight future guidelines for implementing RTs. We conducted a systematic literature review, collecting 105 peer-reviewed studies covering different school grades and courses. Our work presented the mapping of RTs, a graphical summary of our work, the applications of RTs in major courses at primary, middle, and high school levels, and future guidelines for implementing RTs in school classrooms under one umbrella. A significant number of studies reported positive learning outcomes. Still, few studies reported insignificant learning outcomes due to the digital divide, deficiency of proper infrastructure, limited support for innovative practices, lack of compatibility with other existing platforms, and inadequate digital literacy. This study provides recommendations for technologists (human-centered design, dynamic customization, advanced data protection protocols, cross-platform adaptability), teachers (digital competence, lecture planning, peer collaboration, adaptive teaching), institutions (resources allocation, support of interactive practices, impact monitoring, incentives for teachers) policymakers (training programs, equitable access, funding, and resources, clear guidelines for implementation) for successful implementation.
A novel 8T SRAM cell using PFC and PPC VS-CNTFET transistor
Authors: Sharma Vipin Kumar , Kumar Abhishek 
Published: January 2025

Abstract
The 8T static random-access memory (SRAM) cell using carbon nanotube technology, positive feedback, and dynamic supply voltage scaling are presented in this work. Positive feedback strengthens the feedback loop and enhances the noise margin making SRAM cells less susceptible to disturbance and improving the stabilization of the cell by improving read and write timing response. Positive feedback control (PFC) adjusts the cell’s operating condition based on its current and external condition under varying conditions. The positive power supply controlled (PPC) technique in SRAM cell design improves the stability and leakage power consumption by adjusting the voltage level during the operation mode of the cell. The experiment with carbon nanotube field-effect transistor (CNTFET) offers higher drive current and lower power consumption compared to conventional silicon-based transistors. The performance of the 8T SRAM cell incorporating PFC and PPC transistor is investigated with Synopsys HSPICE using the Stanford CNFET model. The proposed SRAM cell architecture archives a 99.99% improvement in power consumption and delay product (PDP) compared to a conventional 6T SRAM cell. The static noise margin of 300 mV ensures better noise immunity and reliable retention of data. The mean value of power consumption is 43.19 nW showing a variance of 93.16 fW and a standard deviation (σ) of 305.2 nW and the mean value of delay is 14.71 ps showing a variance of 1.010 and a standard deviation (σ) of 10.05 ps. CNTFET 8T SRAM cell with the combination of positive feedback and dynamic feedback enhances the performance and efficiency of the memory cell under varying conditions.
Experiences of eating disorder services for people caring for a loved one with an eating disorder in the UK: national survey
Authors: Cribben Hannah , Batchelor Rachel , Macdonald Pamela , Treasure Janet , Cini Erica , Nicholls Dasha , Kan Carol 
Published: January 2025

Background
Research suggests that those caring for a loved one with an eating disorder in the UK report unmet needs and highlight areas for improvement. More research is needed to understand these experiences on a wider, national scale.

Aims
To disseminate a national survey for adults who had experience caring for a loved one with an eating disorder in the UK, informed by the findings of a smaller scale, qualitative study with parents, siblings and partners in the UK.

Method
A cross-sectional web-based survey was disseminated to adults who had experience caring for a loved one with an eating disorder in the UK.

Results
A total of 360 participants completed the survey. Participants described experiences of care received in both children and young people's, and adult services. Those receiving care from children and young people's services generally reported more timely care, greater involvement in care and more confidence managing their loved one's symptoms post-discharge. In both settings, participants identified a number of areas for improvement, including more timely access to care, improved transition processes and discharge planning, and increased involvement in their loved one's care.

Conclusions
This survey captures the experiences of individuals caring for a loved one with an eating disorder in the UK. There are identified discrepancies between experiences of care in children and young people services compared with adult services. Clinical implications and recommendations for improvement are discussed, including improved transition and discharge processes, increased involvement of and/or support for carers themselves, and more timely access to support services for the unwell individual.
Clustering and drivers of symptoms observed at week six after antidepressant treatment in depressed outpatients
Authors: Danon Michel , Poupon Daphnée , Courtet Philippe , Gorwood Philip 
Published: January 2025

Abstract

Background
Depressive symptoms remaining after antidepressant treatment increase the risk of relapse and recurrence. We aimed to analyze the distribution and main drivers of remaining symptoms in patients with a major depressive episode.

Methods
Two independent samples of 8,229 and 5,926 patients from two large naturalistic studies were retrospectively analyzed. DSM-IV criteria for major depressive episodes were assessed during two face-to-face visits with clinicians: before the prescription of a new antidepressant, and after 6 weeks of treatment. The Hospital Anxiety and Depression Scale (HADS) was used to assess baseline severity of anxiety and depression.

Results
In both samples, two clusters of remaining symptoms were observed. The first cluster encompassed symptoms related to a negative emotional and cognitive bias and was specifically driven by the baseline severity of depression. The second cluster encompassed neurovegetative symptoms and was specifically driven by the baseline severity of anxiety.

Conclusions
The baseline anxiety-depressive balance of patients could be considered to adapt the treatment, focusing on emotional and cognitive symptoms with patients with high baseline severity of depression, and neurovegetative symptoms with patients with high baseline anxiety severity.
Editorial
Authors: Σοφός Αλιβίζος (Λοΐζος) , Τριβέλλα Λαμπρινή , ΣΙΑΚΑΣ Σπύρος 
Published: January 2025

Το παρόν τεύχος αποτελεί ένα διακριτό σημείο αναφοράς με θεματική γύρω από την αξιοποίηση των βίντεο στο πεδίο της εκπαίδευσης στο πλαίσιο της ανάπτυξης του μαθήματος «Ανάπτυξη ψηφιακού Οπτικοακουστικού Υλικού» του ΔΜΠΣ « Εκπαιδευτικός Σχεδιασμός Διαδικτυακής (Online) Εκπαίδευσης».
Σε αυτά τα πέντε χρόνια συνεχούς παρουσίας στο χώρο της επιστημονικής έρευνας, το AFIMEC έγινε σημείο συνάντησης για προσεγγίσεις, μελέτες και έρευνες που αναδεικνύουν τη σημασία των οπτικοακουστικών έργων στην εκπαίδευση και τον πολιτισμό. Καθώς το πεδίο εξελίσσεται, αυτό το επιστημονικό περιοδικό με αξιολόγηση προσαρμόζεται, θέτοντας στο επίκεντρο τα ερωτήματα που διαμορφώνουν το μέλλον της κριτικής σκέψης γύρω από τις τέχνες και τα διαδραστικά μέσα.
Σε αυτό το πλαίσιο, το παρόν ειδικό τεύχος φιλοξενεί άρθρα που καλύπτουν θέματα γύρω από την αξιοποίηση των οπτικοακουστικών έργων στο πλαίσιο της εκπαίδευσης.
Η "Πανοπλία δογματική" του Ευθυμίου Ζιγαβηνού στον κώδικα Parisinus gr. 1310
Authors: NIKOY Δημήτριος 
Published: January 2025

The texts inscribed on ff. 146v-152v of codex Parisinus gr. 1310 (15th c.) are wrongly regarded as coming from different works of John Chrysostom. This article shows that they are parts of Euthymios Zigabenos’ Panoplia Dogmatica, which, once identified, were traced to their source; the text delivered by this codex was then compared both to the edition and to the older codices containing the work, and the differences are noted
Asymmetric Response to Global Warming
Authors: Zhukov Anatoliy , Zukow Walery 
Published: January 2025

The study aims to develop critical thinking in the context of global warming, analyze existing approaches to solving this problem, and propose alternative methods of combating climate change.
Materials and methods: Scientific literature was analyzed, including IPCC reports and studies on atmospheric physics and climatology. Theoretical research methods included comparative analysis, mathematical calculations, and a systems approach to assessing climate change. Calculations were made on the efficiency of mirrors in reflecting solar energy with an area ratio of 1:10,000.
Results: It is revealed that the existing theory about the dominant influence of CO₂ on global warming requires critical rethinking. It is established that the content of water vapor in the atmosphere exceeds the content of CO₂ by 100 times. An asymmetric method of combating global warming through mirrors is proposed, demonstrating high potential efficiency. A comparative analysis of three main approaches to solving the problem is carried out: "space umbrella", installation of distributed mirrors, and achieving "carbon neutrality".
Conclusions: A comprehensive approach to solving the problem of global warming is needed, including traditional methods of combating CO₂ emissions and innovative solutions. Mirrors are a promising, cost-effective, and reversible method of fighting global warming. Developing critical thinking is key in finding practical solutions to the climate crisis.
Basic research for ultrasound-guided injection into skeletal muscle lesions in an experimental animal model
Authors: Fujimoto Kiyomitsu , Kanamoto Takashi , Otani Shunya , Miyazaki Ryo , Ebina Kosuke , Nakata Ken 
Published: January 2025

AimsUltrasound-guided injection techniques are expected to enhance therapeutic efficacy for skeletal muscle injuries and disorders, but basic knowledge is lacking. The purpose of this study was to examine the diagnostic accuracy of ultrasound for abnormal skeletal muscle lesions, and to examine the distribution patterns of solution and cells injected into abnormal muscle lesions under ultrasound guidance.MethodsA cardiotoxin (CTX)-induced muscle injury model was used. Briefly, CTX was injected into tibialis anterior muscle in rats under ultrasound observation. First, the diagnostic accuracy of abnormal muscle lesions on ultrasound was examined by comparing ultrasound findings and histology. Next, Fast Green solution and green fluorescent protein (GFP)-labelled cells were simultaneously injected into the abnormal muscle lesions under ultrasound guidance, and their distribution was evaluated.ResultsEvaluation of short-axis ultrasound images and cross-sectional histological staining showed a strong correlation (r = 0.927; p < 0.001) between the maximum muscle damage area in ultrasound and haematoxylin and eosin (H&E) staining evaluations. Histological analysis showed that ultrasound-guided injection could successfully deliver Fast Green solution around the myofibres at the site of injury. In contrast, the distribution of injected cells was very localized compared to the area stained with Fast Green.ConclusionThis experimental animal study demonstrated the potential of ultrasound to quantitatively visualize abnormalities of skeletal muscle. It also showed that ultrasound-guided injections allowed for highly accurate distribution of solution and cells in abnormal muscle tissue, but the patterns of solution and cell distribution were markedly different. Although future studies using a more clinically relevant model are necessary, these results are important findings when considering biological therapies for skeletal muscle injuries and disorders.Cite this article: Bone Joint Res 2025;14(1):33–41.
Is reflux hypersensitivity truly a functional gastrointestinal disorder? A retrospective cross-sectional study
Authors: Wu Yanping , Liao Siyu , Qu Tianyao , Zhou Jiaxuan , Dai Fei , Qin Bin , Xu Xiaoyu , Zhang Jun , Cheng Yan 
Published: January 2025

Background
According to Rome IV, reflux hypersensitivity (RH) represents a novel form of functional esophageal disorder. This study was designed to compare the clinical features of three types of endoscopic-negative heartburn: RH, nonerosive reflux disease (NERD), and functional heartburn (FH).

Methods
Patients with heartburn in a medical center from 01/01/2017 to 10/31/2021 were included. This article presented a blinded retrospective analysis of 24 h MII–pH and HRM tracings from patients with NERD, RH, and FH to compare their clinical characteristics.

Results
A total of 118 patients were included in the study. There were no significant differences in age, sex, BMI, smoking status, or drinking history among RH, NERD and FH. Functional dyspepsia (FD) symptoms were more prone to exist in FH than in NERD (P < 0.05), whereas hiatal hernia was more prevalent in NERD and RH than in FH (P < 0.05). The incidence of anxiety and depression gradually increased in the NERD, RH, and FH groups (P >  0.05). The distal MNBI and PSPW index of the NERD and RH groups were lower than those of the FH group (P < 0.05). The distal MNBI showed good diagnostic potential.

Conclusions
Clear pathological alterations, which are distinct from those of other FGIDs, are observable in RH. It might be inappropriate to categorize RHs within FGIDs.
Exploring potential drug targets for SLE through Mendelian randomization and network pharmacology
Authors: Xu Yanan , Wang Zelin , Jia Tiewen , Liang Shufen 
Published: January 2025

Background
Systemic lupus erythematosus (SLE) is a complex and incurable autoimmune disease, so several drug remission for SLE symptoms have been developed and used at present. However, treatment varies by patient and disease activity, and existing medications for SLE were far from satisfactory. Novel drug targets to be found for SLE therapy are still needed.

Methods
Mendelian randomization (MR), an observational study way, was performed to explore potential drug targets for SLE using protein quantitative trait loci (pQTL) from recently published genome-wide association studies (GWAS) of cerebrospinal fluid (CSF) and plasma proteins, which obtained genetic instruments for 154 CSF proteins of 971 participants, and 734 plasma proteins of 23591 participants. Bidirectional Mendelian randomization analysis, colocalization analysis, and phenotype scanning were performed to find key proteins for SLE. In addition, external data verification was implemented to further consolidate the Mendelian randomization findings. Candidate proteins as targets to find drugs and discuss the druggability. Finally, Network pharmacology and molecular docking methods were used to verify the effects of Voclosporin and Cyclosporine on SLE targets. Protein-protein interaction (PPI) and core target analysis of candidate drugs and SLE overlapping targets were performed to identify potential hub targets and interactions. The affinity between drug targets and SLE targets was confirmed by molecular docking.

Results
In the preliminary analysis, we identified four key proteins as possible drug targets in CSF and plasma proteins, included ICAM-1(P = 4.62E-05, OR = 0.90(0.86, 0.95)), sICAM-1(P = 4.62E-05, OR = 0.49(0.35, 0.69)), FCG2B (P = 7.63E-11, OR = 0.57(0.48, 0.67)), PPP3CA; PPP3R1 (P = 5.47E-07, OR = 0.66(0.57, 0.78)). Among them, ICAM1 was detected in both CSF and plasma proteins. By excluding reverse causality, confounding factors, and linkage disequilibrium (LD), we identified PPP3CA; PPP3R1 as novel drug targets for SLE, including Voclosporin and Cyclosporine. Finally, the Drugbank database shows that novel drugs contain 33 targets for treating SLE. PPI suggested that SIRT1, ACE, PTGS2, and BACE1 were pivotal targets for SLE treatment. In addition, the molecular docking showed that the bioactive molecules of Voclosporin and Cyclosporine had a good affinity with the target of SLE.

Conclusions
Our integrative analysis suggested that levels of circulating PPP3CA; PPP3R1 had causal effects on SLE risk and served as potential treatment targets. Moreover, this study provides new evidence for Voclosporin as an SLE treatment through Mendelian randomization and Network pharmacology, and warrants further clinical investigation.
Discovery of Methylated DNA Biomarkers for Potential Non-Endoscopic Detection of Barrett's Esophagus and Esophageal Adenocarcinoma
Authors: Kalra Andrew , Ma Ke , Cheng Yulan , Tsai Hua-Ling , Wang Hao , Cope Leslie , Yang Yifan , Lunz Daniel , Laun Sarah , Kann Lisa , Jit Simran , Ahmed Yousra , Gheshlaghi Shayan , Tieu Alan H. , Castillo Vincent , Hales Russell , Feliciano Josephine , Lam Vincent , Marrone Kristin , Hui Ken , Ma Michelle , Hughes Robert , Akshintala Venkata , Bull-Henry Kathy , Ha Jinny , Boudadi Karim , Foda Zacharia H. , Battaforano Richard , Khashab Mouen , Shin Eun Ji , Brewer Olaya , Ngamruengphong Saowanee , Ganster Rachel , Jobe Blair A. , Zellenrath Pauline , Spaander Manon , Zaidi Ali H. , Meltzer Stephen J. 
Published: January 2025

Background and Aims:
We sought to develop a minimally-invasive, robust, accessible nonendoscopic strategy to diagnose Barrett’s esophagus (BE), esophageal adenocarcinoma (EAC), and its immediate precursor lesion, high-grade dysplasia (HGD) based on methylated DNA biomarkers applied to a retrievable sponge-capsule device in a cohort representative of the BE population (i.e., mostly short-segment, non-dysplastic BE, NDBE).

Methods:
We identified 12 candidate methylation markers to distinguish normal vs. abnormal esophagus. These 12 markers were first assayed in 21-paired matched NDBE-normal esophageal tissues, then assessed in a case-control study of 234 esophageal samples collected using a sponge-capsule device. A classification algorithm was developed using Least Absolute Shrinkage and Selection Operator (LASSO) in a 199-patient training set and tested in an independent 35-patient test set.

Results:
Twelve markers (A1BG, C9orf50, cg00720137, FLI1, GRAMD1B, HOXB13, IRF4, KCNQ3, NTNG1, SPX, TBC1D30, and USP44) were significantly hypermethylated (i.e., all P<0.05) in BE vs. matched normal esophageal biopsies. A discriminatory three-gene LASSO panel (USP44, TBCD1D30, NELL1), adjusted for age and sex, accurately distinguished HGD or EAC from normal control patients in both training (AUC=0.911, 95%CI=0.863-0.959) and test (AUC=0.969, 95%CI=0.911-1.00) sets. In normal vs. NDBE/LGD/HGD/EAC patients, this algorithm exhibited AUCs of 0.862 (95%CI=0.812-0.912) and 0.864 (95%CI=0.745-0.982) in training and test sets, respectively. In normal vs. NDBE patients, the algorithm yielded AUCs of 0.819 (95%CI=0.748-0.889) and 0.776 (95%CI=0.583-0.968) in training and test sets, respectively.

Conclusions:
This discriminatory biomarker panel algorithm exemplifies a practical nonendoscopic strategy to diagnose BE, HGD, and EAC using a minimally-invasive sponge-capsule device coupled with DNA methylation markers.
Covert Breast Cancer Metastasis to the Gastrointestinal Tract: Is Extra Vigilance Needed?
Authors: Wehbe Sarah , Firkins Stephen A. , Sweeney Jacob R. , Moore Halle C.F. , Rouphael Carol 
Published: January 2025

ABSTRACT
Breast cancer (BC) is a common cancer in females. Spread to the gastrointestinal tract is rare. This is a 61-year-old woman with history of T2N0M0 lobular BC treated 5 years earlier. She underwent endoscopic evaluation for new-onset anemia and was found to have multiple gastric ulcers, a normal-appearing duodenum, and subtle colonic nodules. Targeted and random biopsies of abnormal and normal findings, respectively, showed adenocarcinoma with diffuse immunohistochemical staining compatible with her BC history. This highlights the importance of maintaining a high suspicion index in patients with lobular BC and the utility of random biopsies in such cases.
Rare Finding of Rectal Squamous Metaplasia in Inflammatory Bowel Disease
Authors: Noh Sangkyu , Liu Franklin , Cheong Samuel H. , Taleban Sasha 
Published: January 2025

ABSTRACT
Rectal squamous metaplasia in inflammatory bowel disease is rare. We present 2 cases of rectal squamous metaplasia, one in a patient with Crohn's disease and another with ulcerative colitis. Given the risk of malignant transformation, dysplasia surveillance is important particularly in areas of chronic inflammation. Furthermore, human papilloma virus (HPV) is involved in the pathogenesis of anal squamous cell carcinoma (SCC), but no guidelines exist in the United States for HPV prophylaxis against anal SCC in inflammatory bowel disease. HPV vaccination should be considered in high-risk patients younger than 45 years for prevention of anal SCC, including those with rectal squamous metaplasia.
One Soldier’s War and the New Literary War Hero
Authors: Stinson Logan 
Published: January 2025

To download this paper, please click here.
In the last two decades the major world military powers (the US, the UK/Commonwealth, and Russia) have all been embroiled in long-running asymmetrical conflicts against insurgent or terrorist forces that have proven to be difficult to resolve and increasingly unpopular at home. The fact that these wars are being fought largely by volunteer, contract, or mercenary soldiers has only widened the divide between the military and civilians. In response to this, the literature emerging from these recent conflicts tends to be fragmented, impressionistic, and highly emotional, as veterans try to convey their inner experiences to what they often perceive as an uncaring or hostile audience, while also exploring the experiences of the Other. This article provides a close reading of Arkady Babchenko’s One Soldier’s War, a collection of stories about his two tours of duty in Chechnya, as an early example of this new trend in war literature, and discusses its fragmented structure, its subversion of the clichés of the war genre, and its attempts to set combat veterans apart from the rest of the populace while simultaneously depicting the war and its horrors in vivid detail. We conclude with a brief discussion of the struggle to share the truth and reintegrate back into civilian society that veterans experience, and how this is manifested in literature.