bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyper IgE Syndromes
Authors: Gracci Serena , Novelli Tommaso , D'Elios Sofia , Bernardini Roberto , Peroni Diego 
Published: September 2023

Abstract:
The Hyper IgE Syndromes are rare primary immunodeficiencies characterized by eczema, recurrent skin and respiratory infections and elevated serum IgE levels. Nowadays a genetic-molecular characterization is possible and allows the distinction in various monogenic pathologies, which share some clinical characteristics but also important differences. In addition to long-known STAT3 and DOCK8 gene mutations, in fact, also ZNF341, CARD11, ERBB2IP, IL6R and IL6ST genes mutations can cause the disease. The main clinical manifestations are represented by newborn rash, eczema similar to atopic dermatitis, bacterial and viral skin infections, cold abscesses, respiratory infections with possible pulmonary complications, allergies, gastrointestinal manifestations, malignancies and connective tissue abnormalities. Diagnosis is still a challenge because, especially in the early stages of life, it is difficult to distinguish from other pathologies characterized by eczema and high IgE, such as atopic dermatitis. Several scores and diagnostic pathways have been developed, but it is essential to seek a genetic diagnosis. Treatment is based on prevention and early treatment of infections, meticulous skincare, intravenous immunoglobulins and HSCT, which, in some HIES subtypes, can modify the prognosis. Prognosis is related to the affected gene, but also to early diagnosis, timely treatment of infections and early HSCT.
Immunoglobulin G4-related Disease with Multiple Organs Involvement
Depicted on FDG PET/CT: A Case Report and Literature Review
Authors: Zhu Xiaoying , Wu Lili , Lv Panpan , han Yongmei , Zhuang Yiyu 
Published: September 2023

Introduction:
Immunoglobulin G4-related disease (IgG4-RD) is a relatively rare immune-mediated chronic inflammatory disease with fibrosis newly defined in
recent years. It can involve multiple systems and organs with complex clinical manifestations. Due to mass-like lesions, it is easily misdiagnosed as
tumors.

Case Report:
Herein, we report a 57-year-old woman treated for submandibular mass and anosmia. The serum IgG4 level was increased. The biopsy of the
submandibular gland indicated salivary gland tissue and hyperplasia of fibrous tissue and lymphoid tissue. Immunohistochemical examination
showed a large number of IgG4-positive plasma cells. M protein was found in the patient's serum by immunofixation electrophoresis, and plasma
cell diseases were excluded by bone marrow puncture. PET/CT examination showed that besides the submandibular glands, the parotid gland,
common bile duct, the transitional part of the left renal pelvis and ureter, retroperitoneum in the lower abdomen, and multiple lymph nodes were
also involved. The patient was diagnosed with IgG4-RD, and after treatment with glucocorticoid, the enlargement of submandibular glands and
decreased olfactory function improved. After 14 weeks of treatment, the serological examinations, PET/CT, and ultrasound re-examination results
showed significant improvement. So far, the patient has been followed up for 27 months and is in continuous remission.

Conclusion:
This case report aims to raise awareness of IgG4-RD and explore the value of PET/CT in the diagnosis and efficacy monitoring of the disease.
Association of Obesity based on Different Metabolic Status with Risk of Gout Occurrence in Patients: A National Study
Authors: Wang Yanyan , Liu Luna , Ma Shizhan , Han Junming , Wang Zhixiang , Fan Xiude , Hou Xu 
Published: September 2023

Background:
Obesity often co-exists with metabolic abnormalities, but the results of
studies on the relationship between obesity, metabolic abnormalities and the risk of gout are inconsistent.

Objective:
We aimed to study whether there was a mutual regulation between obesity, metabolic
abnormalities and the risk of gout.

Method:
We conducted a cross-sectional study to expound the association between obesity
based on different metabolic statuses and the risk of gout. Patients were derived from Nationwide
Readmission Database (2018 sample).

Results:
A total of 9,668,330 records were recruited for analysis from January to December. The
risk of gout in the obesity group, metabolic abnormalities group and obesity combined with metabolic
abnormalities group was 1.67 times (OR = 1.67, 95%CI 1.64-1.70), 3.12 times (OR = 3.12,
95%CI 3.09-3.15) and 4.27 times (OR = 4.27, 95%CI 4.22-4.32) higher than that in the normal control
group. For different metabolic components, OR value was highest in hypertension group (OR =
2.65, 95%CI 2.60-2.70 and OR = 4.85, 95%CI 4.73-4.97), followed by dyslipidemia group (OR =
2.23, 95%CI 2.16-2.30 and OR = 3.74, 95%CI 3.55-3.95) and in hyperglycemia group (OR = 1.73,
95%CI 1.66-1.80 and OR = 2.94, 95%CI 2.78-3.11). Fewer components of metabolic syndrome
were associated with a lower risk of gout in both nonobese and obese patients.

Conclusion:
When metabolic abnormalities were present, obesity induced a higher risk of gout.
Different components of metabolic abnormalities had different effects on the risk of gout occurrence,
and the number of metabolic abnormalities was closely related to the risk of gout occurrence.
Follow-up and intervention methods targeting obesity and metabolic abnormalities should
be considered for patients with gout.
Metabolomics: A Tool to Envisage Biomarkers in Clinical Interpretation
of Cancer
Authors: Bhalla Medha , Mittal Roopal , Kumar Manish , Bhatia Rohit , Kushwah Ajay Singh 
Published: September 2023

Background:
Cancer is amongst the most dreadful ailments of modern times, and its
impact continuously worsens global health systems. Early diagnosis and suitable therapeutic
agents are the prime keys to managing this disease. Metabolomics deals with the complete profiling
of cells and physiological phenomena in their organelles, thus helping in keen knowledge of
the pathological status of the disease. It has been proven to be one of the best strategies in the early
screening of cancer.

Objective:
This review has covered the recent updates on the promising role of metabolomics in
the identification of significant biochemical markers in cancer-prone individuals that could lead to
the identification of cancer in the early stages.

Methods:
The literature was collected through various databases, like Scopus, PubMed, and
Google Scholar, with stress laid on the last ten years' publications.

Conclusion:
It was assessed in this review that early recognition of cancerous growth could be
achieved via complete metabolic profiling in association with transcriptomics and proteomics. The
outcomes are rooted in various clinical studies that anticipated various biomarkers like tryptophan,
phenylalanine, lactates, and different metabolic pathways associated with the Warburg effect. This
metabolite imaging has been a fundamental step for the target acquisition, evaluation of predictive
cancer biomarkers for early detection, and outlooks into cancer therapy along with critical evaluation.
Significant efforts should be made to make this technique most reliable and easy.
INCORPORATING CRUCIAL TRANSFERRABLE LIFE-LONG SKILLS IN AN UNDERGRADUATE ADVANCED ENGLISH COURSE AT SOUTH EAST EUROPEAN UNIVERSITY
Authors: Marjanovikj-Apostolovski Marijana 
Published: September 2023

This paper gives an insight into the practical experience of designing and implementing an Advanced English course offered to first year undergraduate students from all Faculties at South East European University which included a research project as a grading component and resulted in an undergraduate student mock conference. It elaborates on the rationale behind the need for incorporating crucial, transferable, life-long skills that students can put to an immediate use during their undergraduate studies, but also skills they can use long after graduating and leaving SEEU. The paper also offers a detailed account of the practical day-to-day challenges faced by both language teachers and students. The peer- and self-evaluation completed at the end of the course reveal overlooked issues that require more attention, modifications and adaptations in the future. Along the way students were made aware of the importance of choosing the most appropriate research method, meticulously citing every source used, distinguishing between editing (as a process that begins as soon as one starts writing) and proofreading (as the activity left for the very end of the writing process when one double or even triple checks that everything is the way it should be before the research report is handed in), and avoiding plagiarism by summarising, paraphrasing and quoting. The Academic skills and research conference offered students practice in giving a well-structured presentation, whereas the follow-up self-evaluation helped them identify areas of possible improvements.Hopefully, thanks to this long and challenging, but also rewarding process, when asked to conduct research on a certain issue, present the results, draw conclusions and recommend a possible course of action or offer possible solutions, the students’ immediate reaction will be: “A-ha, No problem! Been there-done that! I know exactly what I am supposed to do, and I know how to do it!”
Pensarsentirfazer contracolonial em gestão cultural
Authors: Souza Luciano Simões de , Bezerra Laura 
Published: September 2023

O texto compartilha a experiência em curso do “LabGestão pensarsentirfazer contra-hegemônico em política e gestão cultural”, projeto de pesquisa-ação participante que se volta para os processos de gestão cultural de instituições e coletivos da sociedade civil que desenvolvam projetos voltados para a ampliação dos direitos culturais, sociais, políticos e econômicos de grupos sociais historicamente subalternizados, gerando impacto nos territórios os quais estão vinculados. Na Introdução, discute-se como a Ciência da Administração se confundiu com uma visão empreendedora mercantil inviabilizando uma série de conhecimentos e experiências de gestão vinculadas a uma racionalidade não instrumental e a processos mais coletivos de criar e de produzir. Em seguida, propõe que as experiências de gestão cultural vivenciadas especialmente por grupos populares podem oferecer referências importantes para a construção de uma contra-história da administração. Apresentando o contexto de realização do LabGestão – o Território de Identidade do Recôncavo e a UFRB – compartilha os fundamentos e os primeiros passos do projeto, bem como as ações em curso e as previstas no seu primeiro ciclo (2022-2024). Concluindo, o texto apresenta reflexões sobre os desafios da pesquisa-ação participante no campo cultural, defendendo a importância de se produzir conhecimentos para o campo da administração a partir de experiências que os grupos culturais, coletivos e instituições geram nos seus diferentes contextos, considerando os protagonistas dessas experiências como sujeitos da produção desse conhecimento
The Conservatism Principle and Asymmetric Preferences over Reporting Errors
Authors: Chakravarthy Jivas , Shields Timothy W. 
Published: September 2023

ABSTRACT
Accounting conservatism has been described as deriving from preferences for reporting errors to be in the direction of understatement rather than overstatement. We pair reporters with users (who rely on reporters’ information) in a multiperiod experiment. We posit that, under misaligned incentives that motivate aggressive reporting, users view aggressive reports as reflecting exploitative intent and expect that a norm prohibiting aggressive reporting applies. We predict that users use noisy reporting errors to gauge reporters’ norm compliance. We find that, ceteris paribus, users prefer not to be paired with reporters producing overstatement errors likely to reflect aggressive reporting relative to reporters producing understatement errors likely to reflect conservative reporting; alternatively, we find no such asymmetric preferences when the agents’ motives are aligned. The asymmetric preferences cannot be explained by agency theory predictions of payoff maximization or loss aversion. These moral preferences provide an initial condition from which conservatism can endogenously emerge.
Data Availability: Data are available from the authors upon request.
JEL Classifications: B52; D81; D82; M41.
Disturbing the Quiet Life? Competition and CEO Incentives
Authors: Kramer Stephan , Matějka Michal 
Published: September 2023

ABSTRACT
Although it is well understood that product market competition acts as a disciplining mechanism that reduces inefficiencies, our understanding of the implications for firms’ incentive design choices is still limited. We use a comprehensive new measure of competition and examine its effect on four major choices: CEO equity portfolio incentives, annual bonus plan incentives, choice of performance measures, and difficulty of financial performance targets. We find that competition reduces firm profits and total CEO compensation, including equity grants, which then also weakens portfolio incentives. Firms respond by adjusting annual bonus plans to restore incentives. Specifically, we find that competition goes together with stronger bonus plan incentives, more challenging annual performance targets, and a greater emphasis on long-term performance measures. Finally, we show that competition increases performance relative to annual bonus targets, which we interpret as evidence that CEOs work harder but get paid less in highly competitive environments.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: M41; M52.
Analisis Sanitasi Pastry Room di Premier Basko Hotel By Lariz Padang
Authors: Sari Maya Wulan , Yuliana Yuliana 
Published: September 2023

Penelitian ini di latar belakangi oleh pengamatan peneliti tehadap pastry room di Premier Basko Hotel By Lariz Padang, permasalahannya adalah air yang digunakan untuk mengolah makanan kurang hygiene, saluran air limbah mengalir tidak lancar, tempat sampah berdekatan dengan meja pengolahan dan memiliki satu jenis tempat sampah, dan tempat pencucian bahan dan peralatan memiliki satu bak pencuci. Tujuan dari penelitian ini untuk menganalisis sanitasi air bersih, saluran air limbah, tempat sampah, dan tempat pencucian bahan dan peralatan pastry room di Premier Basko Hotel By Lariz Padang. Jenis penelitian ini deskriptif dengan data kualitatif, dengan teknik pengambilan sampel purposive sampling. Data ini di analisis secara reduksi yaitu merangkum, memilih, dan memfokuskan pada hal-hal penting saja, serta menganalisis data yang diperoleh dengan masalah yang diteliti. Hasil penelitian ini menunjukkan air bersih yang digunakan belum memenuhi standar sanitasi, saluran air limbah mengalir kurang lancar, tempat sampah berdekatan dengan makanan serta tempat sampah hanya memiliki satu jenis tanpa ada penutup di bagian atas, dan tempat pencucian bahah dan peralatan hanya memiliki satu bak, salurannya sudah terhubung dan tertutup namun aliran limbahnya kadang tersumbat, kran air yang tersedia hanya suhu panas.
Kata Kunci: Analisis, Sanitasi, Pastry Room
Strategi Pengembangan Sarana dan Prasarana di Objek Wisata Aie Angek Bukik Gadang Nagari Sungai Janiah Kabupaten Solok
Authors: Rama Ilviano , Yuliana Yuliana 
Published: September 2023

Penelitian ini dikarenakan kurang terawatnya sarana dan prasarana yang sudah ada hal ini akan membuat pengunjung merasa tidak nyaman berada di Objek Wisata Aie Angek Bukik Gadang masih terdapatnya masalah terkait sarana dan prasarana seperti sarana toilet yang tidak terawat, tempat parkir yang sempit warung makan dan prasarana jalan yang rusak dan berlubang. Dilihat dari potensi yang ada seperti masih tersedianya lahan yang kosong. Penelitian ini bertujuan untuk meganalisis strategi pengembangan sarana dan prasarana di Objek Wisata Aie Angek Bukik Gadang. Dalam penelitian ini peneliti menggunakan penelitian deskriptif dengan data kualitatif dengan metode survei. Variabel dalam penelitian ini yaitu sarana dan prasarana dengan indikator sarana (Toilet,Tempat Parkir dan Warung Makan) dan Prasarana (Jalan). Dengan informan penelitian ini seperti Dinas Pariwisata Kabupaten Solok, Pengelola Objek Wisata Aie Angek Bukik Gadang, Pemuda dan masyarakat serta pengunjung Objek Wisata Aie Angek Bukik Gadang. Teknik pengumpulan data dalam penelitian ini diambil dengan menggunakan metode wawancara, observasi dan dokumentasi, data analisis SWOT dan strategi. Teknik analisis data menggunakan reduksi data, penyajian data dan pengambilan kesimpulan. Hasil dalam penelitian ini keseluruhan menunjukkan bahwa sarana (Toilet, Tempat Parkir dan Warung Makan) dan Prasarana (Jalan) berpotensi untuk dikembangkan di Objek Wisata Aie Angek Bukik Gadang dilihat dari kekuatan dan peluang yaitu masih adanya lahan yang kosong, pemandangan yang masih asri selama perjalanan mengunjungi Objek Wisata Aie Angek Bukik Gadang serta debit air panas yang terus mengalir. Meskipun ada kelemahan dan ancaman yang terjadi seperti lahan yang masih milik pribadi, biaya yang cukup besar untuk dikembangkan. Sarana dan Prasarana bisa untuk dikembangkan jika Dinas Pariwisata Kabupaten Solok dapat bekerja sama dengan baik dengan masyarakat sekitar objek wisata dan juga pemilik Objek Wisata Aie Angek Bukik Gadang
Key Words : Sarana, Prasarasana
Pengaruh Upah, Lingkungan Kerja dan Iklim Kerja Terhadap Produktivitas Tenaga Kerja di PT. BPR Prima Mertoyudan Sejahtera
Authors: Purwanti Riska Purwanti , Damayanti Dila 
Published: September 2023

Penelitian ini bertujuan untuk mengetahui pengaruh upah, lingkungan, iklim terhadap produktivitas kerja. Populasi yang akan digunakan dalam penelitian ini adalah seluruh karyawan di PT. BPR Prima Mertoyudan Sejahtera sebanyak 46 orang. Penelitian ini menggunakan total sampling. Analisis data menggunakan regresi berganda. Terdapat pengaruh yang signifikan upah terhadap produktivitas tenaga kerja di PT. BPR Prima Mertoyudan Sejahtera. Tidak terdapat pengaruh yang signifikan lingkungan kerja terhadap produktivitas tenaga kerja di PT. BPR Prima Mertoyudan Sejahtera. Terdapat pengaruh yang signifikan iklim terhadap produktivitas tenaga kerja di PT. BPR Prima Mertoyudan Sejahtera. Terdapat pengaruh yang signifikan upah, lingkungan kerja dan iklim terhadap produktivitas tenaga kerja di PT. BPR Prima Mertoyudan Sejahtera.
Peningkatan Berkelanjutan: Pendekatan Analisis Tulang Ikan
Authors: Thahira Agniya 
Published: September 2023

Penelitian ini bertujuan untuk menjelaskan bagaimana penerapan dan kendala di perusahaan UD. Membiri Kendari melalui aplikasi fishbone analysis terkait dengan tenaga kerja, metode kerja, mesin, bahan baku, dan lingkungan. Informan dalam penelitian ini adalah seluruh karyawan UD. Membiri Kendari yang berjumlah 22 orang. Metode pengumpulan data yang digunakan adalah Review Literature dan wawancara, Analisis data yang digunakan adalah analisis deskriptif kualitatif. Hasil penelitian menyatakan bahwa penerapan aplikasi fishbone analysis di masa seperti ini cocok di terapkan, karena sistem ini memiliki kelebihan dimana mampu menemukan kendala, kemudian menggunakannnya untuk melakukan perbaikan kualitas produksi yang berkelanjutan.
Echocardiographic Changes of the Left Ventricle and Left Atrium in COPD
Authors: Mekov E. , Yanev N. , Kurtelova N. , Mihalova T. , Yamakova Y. , Petkov R. 
Published: September 2023

Abstract

Introduction: Cardiac disorders are common in patients with chronic obstructive pulmonary disease (COPD). They worsen shortness of breath and physical capacity and reduce the quality of life. Ultrasound assessment of cardiac function could contribute to assessing the severity of the disease. This study aimed to assess the prognostic significance of echocardiographic parameters on the rate of exacerbations and mortality.

Materials and methods: This was a prospective study of patients with COPD without exacerbation in the previous 1 month. Patients over 40 years of age, current or former smokers with more than 10 pack-years of smoking, and postbronchodilator FEV1/FVC < 0.7 were included. All patients underwent two-dimensional transthoracic Doppler echocardiography at rest by an experienced cardiologist. Echocardiographic parameters were evaluated for prognostic significance on a composite endpoint of moderate and severe exacerbations and death for 1 year. Data from postbronchodilator spirometry, symptoms, quality of life, and demographic and clinical information were also collected.

Results: A total of 96 patients were analyzed with a mean FEV1 of 55.8%. A total of 64 patients (67%) reached the composite endpoint. A significantly higher proportion of patients with deceleration time deviations (86.2 vs. 58.2%, p = 0.0055) and increased septal thickness (55.6 vs. 24.6%, p = 0.0099) reached the primary endpoint at one-year follow-up. Echocardiographic disorders showed a correlation with the quality of life, but not with lung function.

Conclusion: Non-invasive assessment of cardiac function by echocardiography could be included in the complex assessment of disease severity in COPD patients.
Influence of Socio-Demographic Factors on Perceived Stress in Outpatients with Depression and Anxiety in Remission During the COVID-19 Pandemic
Authors: Kamenova I. , Vladimirova R. , Stoyanova V. 
Published: September 2023

Abstract

Objective: The study aimed at identifying the influence of socio-demographic factors on perceived stress during the first and the second “waves” of the COVID-19 pandemic among patients with depression and anxiety in remission compared to controls.

Method: The study was designed as case-control, cross-sectional and non-interventional, and included 60 outpatients with depressive and anxiety disorders in remission and 60 controls with or without family history of affective disorder. A self-assessment scale (Perceived Stress Scale, PSS-10) was used to evaluate perceived stress. The remission was objectified by the Clinical Global Impression scale (CGI-S ≤ 2) and a questionnaire about the socio-demographic features and clinical characteristics of the disorders was completed.

Results: By using multiple logistic regression, it was found that the diagnostic category and/or the relevant family history did not predict higher levels of perceived stress during the COVID-19 pandemic (p > 0.05). Females were associated with higher risk of moderate or high stress (OR = 2.613, p = 0.017), as well as those working from home during the pandemic (OR = 4.00, p = 0.026).

Conclusions: Addressing the COVID-19 effects on mental health in a biopsychosocial manner, the study shows the impact of socio-demographic factors such as gender and work environment in times of a psychosocial crisis. The lack of differences in stress perception by the patients in remission and healthy controls implicates the importance of adequate maintenance treatment and easy access to mental health services in times of crisis.