bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple Electronic Phase Transitions of NiO via Manipulating the NiO6 Octahedron and Valence Control
Authors: Zhou Xuanchi , Mao Wei , Cui Yuchen , Zhang Hao , Liu Qi , Nie Kaiqi , Xu Xiaoguang , Jiang Yong , Chen Nuofu , Chen Jikun 
Published: June 2023

AbstractWhile the multiple Mottronic and electronic phase transitions as recently discovered in nickelates (e.g., ReNiO3) open up a new paradigm in correlated electronic applications, these applications are largely impeded by the intrinsic material metastability of the perovskite nickelates. Herein, the study demonstrates the analogous multiple electronic phase transition properties in the thermodynamically stable NiO, compared to ReNiO3, from both perspectives of band gap regulation and orbital filling regulation. The adjustment in band gap of NiO with t2g6eg2 orbital configuration is achieved via establishing biaxial tensile or compressive interfacial strains that increase or reduce the material resistivity, respectively. The relaxor ferroelectricity of 0.7Pb(Mg2/3Nb1/3)O3‐0.3PbTiO3 (PMNPT) further enables an electric field adjustable resistance switch (ΔR/R) within NiO/PMNPT heterostructure with higher performances (e.g., ΔR/R of 82% upon a bias voltage of 20 V) than the reported oxides/PMNPT heterostructure. Furthermore, the magnitude in resistance switch of the tensile strained NiO via hydrogenation associated Mottronic process reaches ≈1011 that exceeds the previously reported ones. This study highlights the higher material stability and easier growth of NiO, compared to ReNiO3, with analogous multiple Mottronic and electronic phase transition properties that pave the way to its practical applications in correlated electronics.
Acceptor‐Donor‐Acceptor‐Configured Delayed Fluorescence Emitters for Efficient Orange‐Red and White Devices with Low Roll‐off
Authors: He Yi‐Hui , Xie Feng‐Ming , Zhang Kai , Yang Dezhi , Shen Yang , Li Hao‐Ze , Ma Dongge , Li Yan‐Qing , Tang Jian‐Xin 
Published: June 2023

AbstractOrganic light‐emitting diodes (OLEDs) based on thermally activated delayed fluorescence (TADF) materials are promising for the realization of highly efficient emitters. However, severe efficiency roll‐off at high brightness still remains as a huge challenge for TADF‐based OLEDs. Herein, rod‐like orange‐red TADF emitters of 2BNCz‐PZ and 2BNtCz‐PZ with acceptor‐donor‐acceptor (A‐D‐A) configuration are developed by bearing dihydrophenazine donor and discoidal rigid boron, nitrogen‐contained polycyclic aromatic hydrocarbons acceptors. Both emitters exhibit hybrid long‐range/short‐range charge‐transfer excitation for small singlet‐triplet energy splitting, short delayed lifetime, and high photoluminescence quantum yield, leading to fast singlet radiation rate over 107 s−1 and fast reverse intersystem crossing rate over 106 s−1. Furthermore, a horizontal emitting dipole orientation factor over 90% is realized. The optimized orange‐red OLED based on 2BNtCz‐PZ presents a maximum external quantum efficiency (EQE) of 31.0% and a slight EQE roll‐off to 22.2% at 1 000 cd m−2 with emission peak over 600 nm. In addition, the single‐emitting layer white OLEDs achieve a maximum EQE of 30.6% due to the use of these orange‐red dopants with intense charge‐transfer absorption band. This work reveals the potential of the rod‐like A‐D‐A configuration for constructing highly efficient orange‐red TADF emitters with low‐efficiency roll‐off.
Lifelike Transformative Materials for Biohybrid Implants: Inspired by Nature, Driven by Technology
Authors: Fernández‐Colino Alicia , Kiessling Fabian , Slabu Ioana , De Laporte Laura , Akhyari Payam , Nagel Saskia K. , Stingl Julia , Reese Stefanie , Jockenhoevel Stefan 
Published: June 2023

AbstractToday's living world is enriched with a myriad of natural biological designs, shaped by billions of years of evolution. Unraveling the construction rules of living organisms offers the potential to create new materials and systems for biomedicine. From the close examination of living organisms, several concepts emerge: hierarchy, pattern repetition, adaptation, and irreducible complexity. All these aspects must be tackled to develop transformative materials with lifelike behavior. This perspective article highlights recent progress in the development of transformative biohybrid systems for applications in the fields of tissue regeneration and biomedicine. Advances in computational simulations and data‐driven predictions are also discussed. These tools enable the virtual high‐throughput screening of implant design and performance before committing to fabrication, thus reducing the development time and cost of biomimetic and biohybrid constructs. The ongoing progress of imaging methods also constitutes an essential part of this matter in order to validate the computation models and enable longitudinal monitoring. Finally, the current challenges of lifelike biohybrid materials, including reproducibility, ethical considerations, and translation, are discussed. Advances in the development of lifelike materials will open new biomedical horizons, where perhaps what is currently envisioned as science fiction will become a science‐driven reality in the future.
Dry‐Transferable Photoresist Enabled Reliable Conformal Patterning for Ultrathin Flexible Electronics
Authors: Chen Lei , Liu Peng , Feng Bo , Shu Zhiwen , Liang Huikang , Chen Yiqin , Dong Xiaoqian , Xie Jianfei , Duan Huigao 
Published: June 2023

AbstractPhotolithographic techniques, which are widely used in the silicon‐based semiconductor industry, enable the manufacture of high‐yield and high‐resolution features at the micrometer and nanometer scales. However, conventional photolithographic processes cannot accommodate the micro/nanofabrication of flexible and stretchable electronics. In this study, a microfabrication approach that uses a synthesized, environmentally friendly, and dry‐transferable photoresist to enable the reliable conformal manufacturing of thin‐film electronics is reported, which is also compatible with the existing cleanroom processes. Photoresists with high‐resolution, high‐density, and multiscale patterns can be transferred onto various substrates in a defect‐free and conformal‐contact manner, thus enabling multiple wafer reuses. Theoretical studies are conducted to investigate the damage‐free peel‐off mechanism of the proposed approach. The in situ fabrication of various electrical components, including ultralight and ultrathin biopotential electrodes, has been demonstrated, which offer lower interfacial impedance, durability, and stability, and the components are applied to collect electromyography signals with superior signal‐to‐noise ratio (SNR) and quality. Additionally, an exemplary demonstration of a human‐machine interface indicates the potential of these electrodes in many emerging applications, including healthcare, sensing, and artificial intelligence.
Rational Design of Highly Efficient Orange‐Red/Red Thermally Activated Delayed Fluorescence Emitters with Submicrosecond Emission Lifetimes
Authors: Hu Jia‐Xuan , Jiang Shanshan , Zhang Dong‐Hai , Zhao Tianxiang , Lin Fu‐Lin , Meng Lingyi , Chen Xu‐Lin , Lu Can‐Zhong 
Published: June 2023

AbstractThe development of orange‐red/red thermally activated delayed fluorescence (TADF) materials with both high emission efficiencies and short lifetimes is highly desirable for electroluminescence (EL) applications, but remains a formidable challenge owing to the strict molecular design principles. Herein, two new orange‐red/red TADF emitters, namely AC‐PCNCF3 and TAC‐PCNCF3, composed of pyridine‐3,5‐dicarbonitrile‐derived electron‐acceptor (PCNCF3) and acridine electron‐donors (AC/TAC) are developed. These emitters in doped films exhibit excellent photophysical properties, including high photoluminescence quantum yields of up to 0.91, tiny singlet‐triplet energy gaps of 0.01 eV, and ultrashort TADF lifetimes of less than 1 µs. The TADF‐organic light‐emitting diodes employing the AC‐PCNCF3 as emitter achieve orange‐red and red EL with high external quantum efficiencies of up to 25.0% and nearly 20% at doping concentrations of 5 and 40 wt%, respectively, both accompanied by well‐suppressed efficiency roll‐offs. This work provides an efficient molecular design strategy for developing high‐performance red TADF materials.
MSL1 Promotes Liver Regeneration by Driving Phase Separation of STAT3 and Histone H4 and Enhancing Their Acetylation
Authors: He Yucheng , Wang Shichao , Liu Shenghui , Qin Dan , Liu Zhangmei , Wang Liqiang , Chen Xiangmei , Zhang Lisheng 
Published: June 2023

AbstractMale‐specific lethal 1 (MSL1) is critical for the formation of MSL histone acetyltransferase complex which acetylates histone H4 Lys16 (H4K16ac) to activate gene expression. However, the role of MSL1 in liver regeneration is poorly understood. Here, this work identifies MSL1 as a key regulator of STAT3 and histone H4 (H4) in hepatocytes. MSL1 forms condensates with STAT3 or H4 through liquid–liquid phase separation to enrich acetyl‐coenzyme A (Ac‐CoA), and Ac‐CoA in turn enhances MSL1 condensate formation, synergetically promoting the acetylation of STAT3 K685 and H4K16, thus stimulating liver regeneration after partial hepatectomy (PH). Additionally, increasing Ac‐CoA level can enhance STAT3 and H4 acetylation, thus promoting liver regeneration in aged mice. The results demonstrate that MSL1 condensate‐mediated STAT3 and H4 acetylation play an important role in liver regeneration. Thus, promoting the phase separation of MSL1 and increasing Ac‐CoA level may be a novel therapeutic strategy for acute liver diseases and transplantation.
Single Atom Iron‐Doped Graphic‐Phase C3N4 Semiconductor Nanosheets for Augmented Sonodynamic Melanoma Therapy Synergy with Endowed Chemodynamic Effect
Authors: Feng Guiying , Huang Hui , Zhang Min , Wu Zhuole , Sun Dandan , Chen Qiqing , Yang Dayan , Zheng Yuanyi , Chen Yu , Jing Xiangxiang 
Published: June 2023

AbstractSonodynamic therapy (SDT) is a non‐invasive therapeutic modality with high tissue‐penetration depth to induce reactive oxygen species (ROS) generation for tumor treatment. However, the clinical translation of SDT is restricted seriously by the lack of high‐performance sonosensitizers. Herein, the distinct single atom iron (Fe)‐doped graphitic‐phase carbon nitride (C3N4) semiconductor nanosheets (Fe‐C3N4 NSs) are designed and engineered as chemoreactive sonosensitizers to effectively separate the electrons (e−) and holes (h+) pairs, achieving high yields of ROS generation against melanoma upon ultrasound (US) activation. Especially, the single atom Fe doping not only substantially elevates the separation efficiency of the e−‐h+ pairs involved in SDT, but also can serve as high‐performance peroxidase mimetic enzyme to catalyze the Fenton reaction for generating abundant hydroxyl radicals, therefore synergistically augmenting the curative effect mediated by SDT. As verified by density functional theory simulation, the doping of Fe atom significantly promotes the charge redistribution in the C3N4‐based NSs, which improves their synergistic SDT/chemodynamic activities. Both the in vitro and in vivo assays demonstrate that Fe‐C3N4 NSs feature an outstanding antitumor effect by aggrandizing the sono‐chemodynamic effect. This work illustrates a unique single‐atom doping strategy for ameliorating the sonosensitizers, and also effectively expands the innovative anticancer‐therapeutic applications of semiconductor‐based inorganic sonosensitizers.
Spotlighting racism in schools: Teacher mentors and the mediating effect of school safety
Authors: Flitner Anna , McQuillin Samuel , Kornbluh Mariah , Thompson Daria 
Published: June 2023

AbstractYouth are more likely to succeed when they feel safe at school and have access to caring relationships with adults. Systemic racism interrupts access to these assets. Within schools, racially/ethnically minoritized youth encounter policies rooted in racism, leading to decreased perceptions of school safety. Having a teacher mentor may mitigate some of the harmful effects of systemic racism and discriminatory practices. Yet, teacher mentors may not be accessible to all students. In this study, the authors tested a putative explanatory hypothesis for differences between Black and white children's access to teacher mentors. Data from the National Longitudinal Study of Adolescent Health were used. Linear regression models were used to predict access to teacher mentors, and a mediational analysis was conducted to determine the effect of school safety on the relationship between race and teacher mentor access. Results indicate that students from higher SES backgrounds and those with parents who have greater educational attainment are more likely to have a teacher mentor. Furthermore, Black students are less likely than white students to have a teacher mentor, and school safety mediates that relationship. The implications of this study suggest that challenging institutional racism and structures may improve perceptions of school safety and teacher mentor accessibility.
Myelodysplastic syndromes: 2023 update on diagnosis, risk‐stratification, and management
Authors: Garcia‐Manero Guillermo 
Published: June 2023

AbstractDisease overviewThe myelodysplastic syndromes (MDS) are a very heterogeneous group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous leukemia (AML). MDS occurs more frequently in older males and in individuals with prior exposure to cytotoxic therapy.DiagnosisDiagnosis of MDS is based on morphological evidence of dysplasia upon visual examination of a bone marrow aspirate and biopsy. Information obtained from additional studies such as karyotype, flow cytometry, and molecular genetics is usually complementary and may help refine diagnosis. A new WHO classification of MDS was proposed in 2022. Under this classification, MDS is now termed myelodysplastic neoplasms.Risk‐stratificationPrognosis of patients with MDS can be calculated using a number of scoring systems. All these scoring systems include analysis of peripheral cytopenias, percentage of blasts in the bone marrow, and cytogenetic characteristics. The most commonly accepted system is the Revised International Prognostic Scoring System (IPSS‐R). Recently, genomic data has been incorporated resulting in the new IPSS‐M classification.Risk‐adapted therapyTherapy is selected based on risk, transfusion needs, percent of bone marrow blasts, cytogenetic and mutational profiles, comorbidities, potential for allogeneic stem cell transplantation (alloSCT), and prior exposure to hypomethylating agents (HMA). Goals of therapy are different in lower risk patients than in higher risk and in those with HMA failure. In lower risk, the goal is to decrease transfusion needs and transformation to higher risk disease or AML, as well as to improve survival. In higher risk, the goal is to prolong survival. In 2020, two agents were approved in the US for patients with MDS: luspatercept and oral decitabine/cedazuridine. In addition, currently other available therapies include growth factors, lenalidomide, HMAs, intensive chemotherapy, and alloSCT. A number of phase 3 combinations studies have been completed or are ongoing at the time of this report. At the present time there are no approved interventions for patients with progressive or refractory disease particularly after HMA based therapy. In 2021, several reports indicated improved outcomes with alloSCT in MDS as well as early results from clinical trials using targeted intervention.
Oculoauriculofrontonasal syndrome: Refining the phenotype through a new case series and literature review
Authors: Serigatto Henrique Regonaschi , Kokitsu‐Nakata Nancy Mizue , Vendramini‐Pittoli Siulan , Tonello Cristiano , Moura Priscila Padilha , Peixoto Adriano Porto , Gomes Luiz Paulo , Zechi‐Ceide Roseli Maria 
Published: June 2023

AbstractThe oculoauriculofrontonasal syndrome (OAFNS) is a rare condition, with unknown etiology, characterized by the association of frontonasal dysplasia (FND) and oculoauriculovertebral spectrum (OAVS). Main clinical findings include widely spaced eyes, epibulbar dermoid, broad nose, mandibular hypoplasia, and preauricular tags. Here, we describe a case series of 32 Brazilian individuals with OAFNS and review the literature ascertaining individuals presenting phenotypes compatible with the diagnosis of OAFNS, aiming to refine the phenotype. This series emphasizes the phenotypic variability of the OAFNS and highlights the occurrence of rare craniofacial clefts as a part of the phenotype. The ectopic nasal bone, a hallmark of OAFNS, was frequent in our series, reinforcing the clinical diagnosis. The absence of recurrence, consanguinity, chromosomal, and genetic abnormalities reinforces the hypothesis of a nontraditional inheritance model. The phenotypic refinement provided by this series contributes to an investigation regarding the etiology of OAFNS.
Childhood adversity during the post‐apartheid transition and COVID‐19 stress independently predict adult PTSD risk in urban South Africa: A biocultural analysis of the stress sensitization hypothesis
Authors: Kim Andrew Wooyoung , Said Mohamed Rihlat , Norris Shane A. , Naicker Sara , Richter Linda M. , Kuzawa Christopher W. 
Published: June 2023

AbstractObjectivesThe COVID‐19 pandemic in South Africa introduced new societal adversities and mental health threats in a country where one in three individuals are expected to develop a psychiatric condition sometime in their life. Scientists have suggested that psychosocial stress and trauma during childhood may increase one's vulnerability to the mental health consequences of future stressors—a process known as stress sensitization. This prospective analysis assessed whether childhood adversity experienced among South African children across the first 18 years of life, coinciding with the post‐apartheid transition, exacerbates the mental health impacts of psychosocial stress experienced during the 2019 coronavirus (COVID‐19) pandemic (ca. 2020–2021).Materials and MethodsData came from 88 adults who participated in a follow‐up study of a longitudinal birth cohort study in Soweto, South Africa. Childhood adversity and COVID‐19 psychosocial stress were assessed as primary predictors of adult PTSD risk, and an interaction term between childhood adversity and COVID‐19 stress was calculated to evaluate the potential effect of stress sensitization.ResultsFifty‐six percent of adults exhibited moderate‐to‐severe PTSD symptoms. Greater childhood adversity and higher COVID‐19 psychosocial stress independently predicted worse post‐traumatic stress disorder symptoms in adults. Adults who reported greater childhood adversity exhibited non‐significantly worse PTSD symptoms from COVID‐19 psychosocial stress.DiscussionThese results highlight the deleterious mental health effects of both childhood trauma and COVID‐19 psychosocial stress in our sample and emphasize the need for greater and more accessible mental health support as the pandemic progresses in South Africa.
Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease
Authors: Lathe Richard , Schultek Nikki M. , Balin Brian J. , Ehrlich Garth D. , Auber Lavinia Alberi , Perry George , Breitschwerdt Edward B. , Corry David B. , Doty Richard L. , Rissman Robert A. , Nara Peter L. , Itzhaki Ruth , Eimer William A. , Tanzi Rudolph E. ,   the Intracell Research Group Consortium Collaborators
Published: June 2023

AbstractMicrobial infections of the brain can lead to dementia, and for many decades microbial infections have been implicated in Alzheimer's disease (AD) pathology. However, a causal role for infection in AD remains contentious, and the lack of standardized detection methodologies has led to inconsistent detection/identification of microbes in AD brains. There is a need for a consensus methodology; the Alzheimer's Pathobiome Initiative aims to perform comparative molecular analyses of microbes inpost mortembrains versus cerebrospinal fluid, blood, olfactory neuroepithelium, oral/nasopharyngeal tissue, bronchoalveolar, urinary, and gut/stool samples. Diverse extraction methodologies, polymerase chain reaction and sequencing techniques, and bioinformatic tools will be evaluated, in addition to direct microbial culture and metabolomic techniques. The goal is to provide a roadmap for detecting infectious agents in patients with mild cognitive impairment or AD. Positive findings would then prompt tailoring of antimicrobial treatments that might attenuate or remit mounting clinical deficits in a subset of patients.
Network Localization of Awareness in Visual and Motor Anosognosia
Authors: Kletenik Isaiah , Gaudet Kyla , Prasad Sashank , Cohen Alexander L. , Fox Michael D. 
Published: June 2023

ObjectiveUnawareness of a deficit, anosognosia, can occur for visual or motor deficits and lends insight into awareness itself; however, lesions associated with anosognosia occur in many different brain locations.MethodsWe analyzed 267 lesion locations associated with either vision loss (with and without awareness) or weakness (with and without awareness). The network of brain regions connected to each lesion location was computed using resting‐state functional connectivity from 1,000 healthy subjects. Both domain specific and cross‐modal associations with awareness were identified.ResultsThe domain‐specific network for visual anosognosia demonstrated connectivity to visual association cortex and posterior cingulate while motor anosognosia was defined by insula, supplementary motor area, and anterior cingulate connectivity. A cross‐modal anosognosia network was defined by connectivity to the hippocampus and precuneus (false discovery rate p < 0.05).InterpretationOur results identify distinct network connections associated with visual and motor anosognosia and a shared, cross‐modal network for awareness of deficits centered on memory‐related brain structures. ANN NEUROL 2023;94:434–441
Highly Twisted Thermally Activated Delayed Fluorescence (TADF) Molecules and Their Applications in Organic Light‐Emitting Diodes (OLEDs)
Authors: Zhang Tiantian , Xiao Yuxin , Wang Hailan , Kong Shuting , Huang Rongjuan , Ka‐Man Au Vonika , Yu Tao , Huang Wei 
Published: June 2023

AbstractThermally activated delayed fluorescence (TADF) materials have attracted great potential in the field of organic light‐emitting diodes (OLEDs). Among thousands of TADF materials, highly twisted TADF emitters have become a hotspot in recent years. Compared with traditional TADF materials, highly twisted TADF emitters tend to show multi‐channel charge‐transfer characters and form rigid molecular structures. This is advantageous for TADF materials, as non‐radiative decay processes can be suppressed to facilitate efficient exciton utilization. Accordingly, OLEDs with excellent device performances have also been reported. In this Review, we have summarized recent progress in highly twisted TADF materials and related devices, and give an overview of the molecular design strategies, photophysical studies, and the performances of OLED devices. In addition, the challenges and perspectives of highly twisted TADF molecules and the related OLEDs are also discussed.