bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Working Women’s Self-Reported Subjective Wellbeing and Quality of Interpersonal Relationships During COVID-19: A Quantitative Comparison of Essential and Non-essential Workers in Singapore
Authors: Tan Poh Lin , Lim-Soh Jeremy 
Published: February 2023

AbstractThe COVID-19 pandemic has affected working women’s well-being in different ways due to contrasting national responses. This article focuses on the specific context of Singapore, which implemented differentiated rules for workers: essential workers continued to report to workplaces, while non-essential workers were required to work from home. This policy had far-reaching implications for working women, who are more likely than husbands to juggle paid work and household duties. The article uses longitudinal data collected in 2018 and during the pandemic in 2020, specifically during Singapore’s lockdown period, to measure changes in 287 working women’s self-reported levels of stress, fatigue, and quality of interpersonal relationships by essential worker status. While all workers were affected by the pandemic, female essential workers were more likely than their non-essential peers to report declines in stress levels from 2018 to 2020, and less likely to report changes in spousal relationships, both positive and negative. Findings suggest that the differences were driven by exposure to quarantine conditions faced by non-essential workers. Our results highlight the importance of policies supporting frontline workers and more gender-equitable labour market policies to support married women juggling the twin demands of employment and household responsibilities.
Low-cost integrated INS/GNSS using adaptive H∞ Cubature Kalman Filter
Authors: Taghizadeh S. , Safabakhsh R. 
Published: February 2023

AbstractWe proposed an adaptive H-infinity Cubature Kalman Filter (AH∞CKF) to improve the navigation accuracy of a highly manoeuvrable unmanned aerial vehicle (UAV). AH∞CKF fuses the Inertial Navigation System (INS) and Global Navigation Satellite System (GNSS) measurements. Traditional state estimation filters like extended Kalman filters (EKF) and cubature Kalman filters (CKF) assume Gaussian noises. However, their performance degrades for non-Gaussian noises and system uncertainties encountered in real-world applications. Thus, designing filters robust to noise and distribution is crucial. AH∞CKF combines H∞CKF design with an added adaptive factor to adjust the state estimation covariance matrix according to measurements by exploiting the square root method to yield more numerically stable results (SrAH∞CKF). We conducted multiple dynamically rich flight tests to validate our claims using a UAV equipped with a commercially well-known GNSS solution. Results show that the SrAH∞CKF state estimation outperforms EKF and CKF methods on average by 90% in various statistical measures.
AFTER THE ENLIGHTENMENT: THE REDISCOVERY OF AVERROES BY TIEDEMANN AND HERDER
Authors: Schick Stefan 
Published: February 2023

AbstractBoth Arabic modernists and Western humanists often regard the Muslim philosopher Averroes as one of the earliest precursors of Kant and the European Enlightenment. In contrast to this reputation, this paper argues that it was Kant’s critics Herder and Tiedemann who rediscovered Averroes. Tiedemann was the first German historiographer to give an accurate account of Averroes’ thought. This was accompanied by a re-evaluation of Averroes by Herder in his Letters for the Advancement of Humanity, in which he recognized the similarity between his own concept of the spirit of the age as historical reason – his alternative to the Enlightenment concept of a universal and ahistorical reason – and Averroes’ concept of a single material intellect for all individual human minds. Finally, the paper outlines the possible connections between Averroes’ interpretation of Aristotle’s intellect and Hegel’s concept of reason in history.
Machine Learning for Single‐Station Detection of Transient Deformation in GPS Time Series With a Case Study of Cascadia Slow Slip
Authors: Xue Xueming , Freymueller Jeffrey T. 
Published: February 2023

AbstractInspired by recent studies using various machine learning methods on different types of time series data (e.g., seismic, sea floor pressure), this study proposes a simple machine learning method, based on the recurrent neural network approach, for transient deformation detection in Global Positioning System time series. Unlike most previous studies using a sliding window technique, our model uses a single data point of the entire time series as sequential input and directly outputs the transient probability for all points in the time series. As a case study, we apply our method to detect slow‐slip events in Cascadia between 2005 and 2016. The specific model is first trained and validated using synthetic data, and then used to detect slow‐slip events on real Cascadia data. Based on our detection results, the spatial extent, duration, and migration of the major events are consistent with previous studies. As a benchmark, we compared our results in detail with those based on the Relative Strength Index (RSI). In general, our ML model detects more stations likely to be associated with nearby slow‐slip events than the RSI model, especially if there are data gaps in the timeseries.
Important Ice Processes Are Missed by the Community Earth System Model in Southern Ocean Mixed‐Phase Clouds: Bridging SOCRATES Observations to Model Developments
Authors: Zhao Xi , Liu Xiaohong , Burrows Susannah , DeMott Paul J. , Diao Minghui , McFarquhar Greg M. , Patade Sachin , Phillips Vaughan , Roberts Greg C. , Sanchez Kevin J. , Shi Yang , Zhang Meng 
Published: February 2023

AbstractGlobal climate models (GCMs) are challenged by difficulties in simulating cloud phase and cloud radiative effect over the Southern Ocean (SO). Some of the new‐generation GCMs predict too much liquid and too little ice in mixed‐phase clouds. This misrepresentation of cloud phase in GCMs results in weaker negative cloud feedback over the SO and a higher climate sensitivity. Based on a model comparison with observational data obtained during the Southern Ocean Cloud Radiation and Aerosol Transport Experimental Study, this study addresses a key uncertainty in the Community Earth System Model version 2 (CESM2) related to cloud phase, namely ice formation in pristine remote SO clouds. It is found that sea spray organic aerosols (SSOAs) are the most important type of ice nucleating particles (INPs) over the SO with concentrations 1 order of magnitude higher than those of dust INPs based on measurements and CESM2 simulations. Secondary ice production (SIP) which includes riming splintering, rain droplet shattering, and ice‐ice collisional fragmentation as implemented in CESM2 is the dominant ice production process in moderately cold clouds with cloud temperatures greater than −20°C. SIP enhances the in‐cloud ice number concentrations (Ni) by 1–3 orders of magnitude and predicts more mixed‐phase (with percentage occurrence increased from 15% to 21%), in better agreement with the observations. This study highlights the importance of accurately representing the cloud phase over the pristine remote SO by considering the ice nucleation of SSOA and SIP processes, which are currently missing in most GCM cloud microphysics parameterizations.
Adipokines at the crossroads of obesity and mesenchymal stem cell therapy
Authors: Pham Duc-Vinh , Nguyen Thi-Kem , Park Pil-Hoon 
Published: February 2023

AbstractMesenchymal stem cell (MSC) therapy is an emerging treatment strategy to counteract metabolic syndromes, including obesity and its comorbid disorders. However, its effectiveness is challenged by various factors in the obese environment that negatively impact MSC survival and function. The identification of these detrimental factors will provide opportunities to optimize MSC therapy for the treatment of obesity and its comorbidities. Dysregulated production of adipokines, a group of cytokines and hormones derived from adipose tissue, has been postulated to play a pivotal role in the development of obesity-associated complications. Intriguingly, adipokines have also been implicated in the modulation of viability, self-renewal, proliferation, and other properties of MSC. However, the involvement of adipokine imbalance in impaired MSC functionality has not been completely understood. On the other hand, treatment of obese individuals with MSC can restore the serum adipokine profile, suggesting the bidirectionality of the adipokine–MSC relationship. In this review, we aim to discuss the current knowledge on the central role of adipokines in the crosstalk between obesity and MSC dysfunction. We also summarize recent advances in the use of MSC for the treatment of obesity-associated diseases to support the hypothesis that adipokines modulate the benefits of MSC therapy in obese patients.
Androgen receptor variant 7 exacerbates hepatocarcinogenesis in a c-MYC-driven mouse HCC model
Authors: Kido Tatsuo , Lau Yun-Fai Chris 
Published: February 2023

AbstractAndrogen receptor variant 7 (AR-V7), an AR isoform with a truncated ligand-binding domain, functions as a transcription factor in an androgen-independent manner. AR-V7 is expressed in a subpopulation of hepatocellular carcinoma (HCC), however, its role(s) in this cancer is undefined. In this study, we investigated the potential roles of AR-V7 in hepatocarcinogenesis in vivo in a c-MYC-driven mouse HCC model generated by the hydrodynamic tail-vein injection system. The impacts of AR-V7 on gene expression in mouse HCC were elucidated by RNA-seq transcriptome and ontology analyses. The results showed that AR-V7 significantly exacerbated the c-MYC-mediated oncogenesis in the livers of both sexes. The transcriptome and bioinformatics analyses revealed that AR-V7 and c-MYC synergistically altered the gene sets involved in various cancer-related biological processes, particularly in lipid and steroid/sterol metabolisms. Importantly, AR-V7 suppressed a tumor suppressor Claudin 7 expression, upregulated by c-MYC overexpression via the p53 signaling pathway. Claudin 7 overexpression significantly suppressed the c-MYC-driven HCC development under p53-deficient conditions. Our results suggest that the AR-V7 exacerbates the c-MYC-driven hepatocarcinogenesis by potentiating the oncogenic roles and minimizing the anti-oncogenic functions of c-MYC. Since AR-V7 is expressed in a subpopulation of HCC cases, it could contribute to the inter- and intra-heterogeneity of HCC.
COX-2/PGE2 upregulation contributes to the chromosome 17p-deleted lymphoma
Authors: Qi Lu , Pan Xiangyu , Chen Xuelan , Liu Pengpeng , Chen Mei , Zhang Qi , Hang Xiaohang , Tang Minghai , Wen Dan , Dai Lunzhi , Chen Chong , Liu Yu , Xu Zhengmin 
Published: February 2023

AbstractDeletions of chromosome 17p, where TP53 gene locates, are the most frequent chromosome alterations in human cancers and associated with poor outcomes in patients. Our previous work suggested that there were p53–independent mechanisms involved in chromosome 17p deletions-driven cancers. Here, we report that altered arachidonate metabolism, due to the deficiency of mouse Alox8 on chromosome 11B3 (homologous to human ALOX15B on chromosome 17p), contributes to the B cell malignancy. While the metabolites produced from lipoxygenase pathway reduced, chromosome 11B3 deletions or Alox8 loss, lead to upregulating its paralleling cyclooxygenase pathway, indicated by the increased levels of oncometabolite prostaglandin E2. Ectopic PGE2 prevented the apoptosis and differentiation of pre-B cells. Further studies revealed that Alox8 deficiency dramatically and specifically induced Cox-2(Ptgs2) gene expression. Repressing Cox-2 by its shRNAs impaired the tumorigenesis driven by Alox8 loss. And, in turn, tumor cells with Alox8 or 11B3 loss were sensitive to the COX-2 inhibitor celecoxib. This correlation between COX-2 upregulation and chromosome 17p deletions was consistent in human B-cell lymphomas. Hence, our studies reveal that the arachidonate metabolism abnormality with unbalanced ALOX and COX pathways underlies human cancers with 17p deletions and suggest new susceptibility for this disease.
A molecular characterization and clinical relevance of microglia-like cells derived from patients with panic disorder
Authors: You Min-Jung , Rim Chan , Bang Minji , Sung Soyoung , Kim Hui-Ju , Lee Sang-Hyuk , Kwon Min-Soo 
Published: February 2023

AbstractFew studies report the microglia involvement in the pathogenesis of panic disorder (PD), although the crucial role of microglia in other neuropsychiatric diseases is being emphasized. In addition, there is no report to characterize the phenotypic and functional levels of PD patient-derived microglia to find their clinical relevance. Herein, we used a model to induce patient-derived microglia-like cells (iMGs) to clarify the molecular characteristics and function of PD-iMGs. We established iMGs from 17 PD patients and 16 healthy controls (non-psychiatric controls, HC). PD-iMGs showed increased T-cell death-associated gene-8 expression per the proposal of a previous in vivo study. In addition, we found that patient-derived iMGs showed reduced phagocytosis and increased TREM2 expression. We analyzed the phenotype of the PD-iMGs by RNA sequencing. The PD-iMGs clustered together distinct from HC-iMGs. Gene set enrichment analysis revealed the involvement of cholesterol biosynthesis and steroid metabolism in PD-iMGs. Regarding the cholesterol synthesis pathway, we discovered ACAT2 and DHCR7 as the most impacted genes related to a character of PD-iMGs compared to HC-iMGs. The ACAT2, a major cholesterol esterifier, was increased in PD-iMGs. Nevertheless, PD-iMGs did not show lipid droplet accumulation. Interestingly, ACAT2 expression was inversely correlated with the severity of depression and anxiety sensitivity to publicly observable anxiety reactions. We propose that microglia of PD patients have unique characteristics with dysregulation of cholesterol biosynthesis pathway and impaired phagocytosis, reflecting clinical phenotype.
Using live stream technology to conduct workplace observation assessment of trainee dental nurses: an evaluation of effectiveness and user experience
Authors: Taylor Caroline , Ikiroma Adalia , Crowe Anne , Felix David H , Grant Gillian , Mitchell Lucy , Ross Teresa , Saunderson Margaret , Young Linda 
Published: February 2023

Abstract
Aim/objective
This study evaluates the effectiveness and users’ experience of using live stream technology to conduct workplace observation assessments of trainee dental nurses. Information on the usability, accessibility, and general satisfaction of this technological technique were collected.

Materials and methods
This nationwide cross-sectional survey was conducted in Scotland and included one focus group and three online questionnaires with qualitative and quantitative questions. The quantitative responses were described using standard descriptive analysis, while the quantitative data were investigated using thematic analysis.

Results
Eighty-one trainee dental nurses, 35 clinicians and 19 assessors participated in this study. Live stream observation was generally well received by the trainee dental nurses and clinicians, who thought that it had helped increase their confidence to perform practical skills. The assessors also stated that overall satisfaction was high, and that live stream observation met their expectations for efficacy. However, several technical challenges, such as network issues were brought up by responders.

Conclusion
This study provides evidence that workplace observation assessments can be performed in the future by using live stream technology. However, additional investigation and comparison will aid in determining the most effective way of using this approach and providing feedback to promote learning among dental trainees.
PDHB-AS suppresses cervical cancer progression and cisplatin resistance via inhibition on Wnt/β-catenin pathway
Authors: Chi Chi , Hou Wenjie , Zhang Yi , Chen Jie , Shen Zongji , Chen Youguo , Li Min 
Published: February 2023

AbstractCervical cancer (CC) is the most prevalent gynecological malignancy occurring in the cervix. Long non-coding RNAs (lncRNAs) can act as oncogenes or anti-oncogenes in CC development. Here, we investigated the functional role and detailed mechanism of lncRNA pyruvate dehydrogenase E1 subunit beta antisense (PDHB-AS) in CC. At first, we found that PDHB-AS was significantly down-regulated in CC cells. Besides, overexpression of PDHB-AS repressed CC cell malignant behaviors. HKF-derived exosomes carried miR-4536-5p to CC cells and thereby inhibited PDHB-AS expression. Moreover, PDHB-AS inactivated the Wnt/β-catenin pathway via impeding the nuclear translocation of β-catenin in CC cells. In addition, miR-582-5p could bind with both PDHB-AS and Dickkopf-1 (DKK1). PDHB-AS recruited poly(A) binding protein cytoplasmic 1 (PABPC1) to inhibit Wnt7b expression. PDHB-AS interacted with RNA-binding motif protein X-linked (RBMX) to regulate cisplatin resistance in CC. Finally, we conducted in vivo experiments to confirm that HKF promoted CC tumor growth whereas PDHB-AS suppressed CC tumor growth. Collectively, PDHB-AS plays a tumor-suppressive role in the progression of CC, which suggests the therapeutic potential of PDHB-AS for CC.
PINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products
Authors: Li Wei , Jiang Wang-Sheng , Su Ya-Ru , Tu Ke-Wu , Zou Lin , Liao Cong-Rui , Wu Qian , Wang Zi-Han , Zhong Zhao-Ming , Chen Jian-Ting , Zhu Si-Yuan 
Published: February 2023

AbstractOsteoblast apoptosis plays an important role in age-related bone loss and osteoporosis. Our previous study revealed that advanced oxidation protein products (AOPPs) could induce nicotinamide adenine dinucleotide phosphate oxidase (NOX)-derived reactive oxygen species (ROS) production, cause mitochondrial membrane potential (ΔΨm) depolarization, trigger the mitochondria-dependent intrinsic apoptosis pathway, and lead to osteoblast apoptosis and ultimately osteopenia and bone microstructural destruction. In this study, we found that AOPPs also induced mitochondrial ROS (mtROS) generation in osteoblastic MC3T3-E1 cells, which was closely related to NOX-derived ROS, and aggravated the oxidative stress condition, thereby further promoting apoptosis. Removing excessive ROS and damaged mitochondria is the key factor in reversing AOPP-induced apoptosis. Here, by in vitro studies, we showed that rapamycin further activated PINK1/Parkin-mediated mitophagy in AOPP-stimulated MC3T3-E1 cells and significantly alleviated AOPP-induced cell apoptosis by eliminating ROS and damaged mitochondria. Our in vivo studies revealed that PINK1/Parkin-mediated mitophagy could decrease the plasma AOPP concentration and inhibit AOPP-induced osteoblast apoptosis, thus ameliorating AOPP accumulation-related bone loss, bone microstructural destruction and bone mineral density (BMD) loss. Together, our study indicated that therapeutic strategies aimed at upregulating osteoblast mitophagy and preserving mitochondrial function might have potential for treating age-related osteoporosis.
RBM3 suppresses stemness remodeling of prostate cancer in bone microenvironment by modulating N6-methyladenosine on CTNNB1 mRNA
Authors: Zhang Shouyi , Lv Chengcheng , Niu Yichen , Li Changqi , Li Xiuming , Shang Yu , Zhang Yunchao , Zhang Yue , Zhang Yong , Zeng Yu 
Published: February 2023

AbstractBone metastasis is the most happened metastatic event in prostate cancer (PCa) and needs a large effort in treatment. When PCa metastasizes to the bone, the new microenvironment can induce the epigenome reprogramming and stemness remodeling of cancer cells, thereby increasing the adaptability of cancer cells to the bone microenvironment, and this even leads to the occurrence of secondary tumor metastasis. Our group has previously found that RNA binding motif 3 (RBM3) affects the stem cell-like properties of PCa by interfering with alternative splicing of CD44. However, whether RBM3, as a stress-response protein, can resist microenvironmental remodeling of PCa particularly in bone metastasis remains unknown. By co-culturing PCa cells with osteoblasts to mimic PCa bone metastases, we found that RBM3 upregulates the N6-methyladenosine (m6A) methylation on the mRNA of catenin beta 1 (CTNNB1) in a manner dependent on methyltransferase 3 (METTL3), an N6-adenosine-methyltransferase complex catalytic subunit. Consequently, this modification results in a decreased stability of CTNNB1 mRNA and a followed inactivation of Wnt signaling, which ultimately inhibits the stemness remodeling of PCa cells by osteoblasts. Thus, the present study may extend our understanding of the inhibitory role of RBM3 on particularly bone metastasis of PCa.
Polo-like kinase 4 inhibitor CFI-400945 inhibits carotid arterial neointima formation but increases atherosclerosis
Authors: Sun Jiaxing , Belke Darrell , Gui Yu , Chen Yong-Xiang , Zhou Shenghua , Zheng Xi-Long 
Published: February 2023

AbstractNeointima lesion and atherosclerosis are proliferative vascular diseases associated with deregulated proliferation of vascular smooth muscle cells (SMCs). CFI-400945 is a novel, highly effective anticancer drug that inhibits polo-like kinase 4 (PLK4) and targets mitosis. In this study, we aim to investigate how CFI-400945 affects the development of proliferative vascular diseases. In C57BL/6 mice, neointima formation was generated by complete carotid ligation. In apolipoprotein E knockout (ApoE−/−) mice fed a high-fat diet, atherosclerosis was induced by partial carotid ligation. CFI-400945 was directly applied to carotid arteries via a perivascular collar. Our results showed that CFI-400945 drastically inhibited neointima formation but significantly accelerated atherosclerosis. In vitro studies showed that CFI-400945 treatment induced SMC polyploidization and arrested cells in the G2/M phase. CFI-400945 treatment upregulated p53 and p27 expression but decreased p21 and cyclin B1 expression. CFI-400945 also induced SMC apoptosis, which was inhibited by hydroxyurea, a DNA synthesis inhibitor that inhibits polyploidization. Furthermore, CFI-400945 caused supernumerary centrosomes, leading to mitotic failure, resulting in polyploidization. In conclusion, CFI-400945 prevents carotid arterial neointima formation in C57BL/6 mice but accelerates atherosclerosis in ApoE−/− mice, likely through mitotic arrest and subsequent induction of polyploidization and apoptosis.
Bulk evidence of anisotropic s-wave pairing with no sign change in the kagome superconductor CsV3Sb5
Authors: Roppongi M. , Ishihara K. , Tanaka Y. , Ogawa K. , Okada K. , Liu S. , Mukasa K. , Mizukami Y. , Uwatoko Y. , Grasset R. , Konczykowski M. , Ortiz B. R. , Wilson S. D. , Hashimoto K. , Shibauchi T. 
Published: February 2023

AbstractThe recently discovered kagome superconductorsAV3Sb5(A= K, Rb, Cs) exhibit unusual charge-density-wave (CDW) orders with time-reversal and rotational symmetry breaking. One of the most crucial unresolved issues is identifying the symmetry of the superconductivity that develops inside the CDW phase. Theory predicts a variety of unconventional superconducting symmetries with sign-changing and chiral order parameters. Experimentally, however, superconducting phase information inAV3Sb5is still lacking. Here we report the impurity effects in CsV3Sb5using electron irradiation as a phase-sensitive probe of superconductivity. Our magnetic penetration depth measurements reveal that with increasing impurities, an anisotropic fully-gapped state changes to an isotropic full-gap state without passing through a nodal state. Furthermore, transport measurements under pressure show that the double superconducting dome in the pressure-temperature phase diagram survives against sufficient impurities. These results support that CsV3Sb5is a non-chiral, anisotropics-wave superconductor with no sign change both at ambient and under pressure.