bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disitamab Vedotin (RC48) combined with bevacizumab for treatment of HR-negative/HER2-positive metastatic breast cancer with liver and brain involvement: A case report
Authors: Qu Fei , Liu Qian , Lu Rongrong , Li Wei 
Published: August 2023

BackgroundThe overexpression of human epidermal growth factor receptor 2 (HER2) is strongly correlated with an elevated risk of developing distant metastases, particularly brain metastases, in breast cancer (BC) cases. RC48 (also known as Disitamab vedotin), represents a promising antibody-drug conjugate (ADC), that comprises three well-defined components: hertuzumab against the prominent tumor target-HER2, monomethyl auristatin E (MMAE) and a cleavable linker. Preclinical studies have demonstrated its robust antitumor activity in BC patient-derived xenograft models with HER2-positive or HER2-low expression. Additionally, antiangiogenic drugs like bevacizumab have shown potential efficacy on advanced BC via inhibiting pathological neovascularizationits.Case presentationHere, we will share our experience in treating a 49-year-old woman initially diagnosed with stage IV breast cancer characterized by hormone receptor (HR)-negativity and HER2-positivity. This complex case entailed brain and liver metastases, and the patient exhibited resistance to various HER2-targeted treatment regimens. Finally, the patient received RC48 plus bevacizumab as the advanced forth-line treatment, which was well tolerated with no observed toxicities. Subsequent radiological assessments revealed remarkable regression in the brain metastatic lesions, classified as having partial response based on the RECIST 1.1 system. The period of progression-free survival (PFS) was 7 months.ConclusionThe present study underscores the efficacy of systemic treatment with RC48 in conjunction, showcasing substantial enhancement in both radiographic indicators and clinical symptomatology among patients with brain metastatic breast cancer (BMBC). More specifically, the sequential application of ADCs in combination with antiangiogenics presents a novel avenue for advancing the treatment landscape of metastatic BC.
Research on Morphological Indicator Extraction Method of Pinus massoniana Lamb. Based on 3D Reconstruction
Authors: Li Yurong , Xia Haifei , Liu Ying , Ji Kaihao , Huo Lintao , Ni Chao 
Published: August 2023

Pinus massoniana (Lamb.) is an important plantation species in southern China. Accurate measurement of P. massoniana seedling morphological indicators is crucial for accelerating seedling quality assessment. Machine vision, with its objectivity and stability, can replace human eyes in performing these measurements. In this paper, a measurement method for seedling morphological indicators based on Euclidean distance, Laplacian contraction, PointNet++, and 3D reconstruction is proposed. Firstly, multi-angle sequence images of 30 one-year-old P. massoniana seedlings were collected, distorted, and corrected to generate a sparse point cloud through the Structure-from-Motion (SFM) and dense point cloud through the Patch-Based Multiple View Stereo (PMVS). Secondly, a Dense Weighted Semantic Segmentation Model based on PointNet++ was designed, achieving effective segmentation of the P. massoniana seedling point clouds. Finally, a multi-iteration plane method based on Laplacian contraction was proposed. The new skeleton points were refined by minimizing the Euclidean distance, iteratively generating the optimal morphological skeleton, thus facilitating the extraction of morphological indicators. The experimental results demonstrated a good correlation between the machine vision-extracted morphological indicators (including plant height, ground diameter, and height-to-diameter ratio) and manually measured data. The improved PointNet++ model achieved an accuracy of 0.9448 on the training set. The accuracy and Mean Intersection over Union (MIoU) of the test set reached 0.9430 and 0.7872, respectively. These findings can provide reliable technical references for the accurate assessment of P. massoniana seedling quality and the promotion of digital forestry construction.
Four New Species of Small-Spored Alternaria Isolated from Solanum tuberosum and S. lycopersicum in China
Authors: Gou Yanan , Aung Sein Lai Lai , Guo Zhuanjun , Li Zhi , Shen Shulin , Deng Jianxin 
Published: August 2023

Small-spored Alternaria species have been frequently isolated from diseased leaves of Solanum plants. To clarify the diversity of small-spored Alternaria species, a total of 118 strains were obtained from leaf samples of S. tuberosum and S. lycopersicum in six provinces of China during 2022–2023. Based on morphological characterization and multi-locus phylogenetic analysis of the internal transcribed spacer of the rDNA region (ITS), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), translation elongation factor 1 alpha (TEF1), RNA polymerase second largest subunit (RPB2), Alternaria major allergen gene (Alt a 1), endopolygalacturonase gene (EndoPG) and an anonymous gene region (OPA10-2), seven species were determined, including four novel species and three known species (A. alternata, A. gossypina and A. arborescens). The novel species were described and illustrated as A. longxiensis sp. nov., A. lijiangensis sp. nov., A. lycopersici sp. nov. and A. solanicola sp. nov.. In addition, the pathogenicity of the seven species was evaluated on potato leaves. The species exhibited various aggressiveness, which could help in disease management.
POLYMORPHISM OF THE SCD AND FABP4 GENES IN BEEF CATTLE OF THE KALMYK BREED
Authors: АМЕРХАНОВ Х.А. , КЛИМЕНКО А.И. , ШЕВХУЖЕВ А.Ф. , ДУБОВСКОВА М.П. , КАНИБОЛОЦКАЯ А.А. 
Published: August 2023

Изучено влияние однонуклеотидных полиморфизмов (SNP) в генах стеароил-КоА-десатуразы (SCD) и FABP4, ответственных за регуляцию внутриклеточного белка, связывающего жирные кислоты (FABP4). Эти гены ассоциированы с уровнем и свойствами жирнокислотного состава в организме коров, а также влияют на формирование продуктивных качеств у мясного скота. Целью работы было изучение полиморфизмов генов SCD и FABP4 и их влияния на живую массу у бычков калмыцкой породы. Исследования проводили в Ставропольском крае. Объектом изучения являлись бычки (n=156) в возрасте 8 мес. Установлено, что животные — носители более распространенного гетерозиготного ТС-генотипа в замене T878C (p.Ala293Val., 26:21272422, rs41255693) в гене SCD имели более высокую живую массу по сравнению с носителями гомозиготных вариантов TT- и СС-генотипов на 2,5 и 17% соответственно, а также среди всего исследованного поголовья по двум изучаемым генам. Животные, носители гомозиготного АА-генотипа замены c.408A>G в гене FABP4, имели наибольшую живую массу среди всех исследованных особей по этому гену, при этом носители AG-генотипа отличались наименьшей массой. Изученные полиморфизмы генов SCD и FABP4 имеют высокую достоверную связь с живой массой у бычков калмыцкой породы и могут быть использованы в качестве ДНК-маркеров в селекции калмыцкой породы крупного рогатого скота.
The influence of single nucleotide polymorphisms (SNPs) in the stearoyl-CoA desaturase SCD and FABP4 genes responsible for the regulation of intracellular fatty acid-binding protein (FABP4) was studied. These genes are associated with the level and properties of the fatty acid composition in the body of cows, and also affect the formation of productive qualities in beef cattle. The aim of the work was to study the polymorphisms of the SCD and FABP4 genes and their effect on live weight in Kalmyk bulls. The research was carried out in the Stavropol Territory. The object of the study were bulls (n=156) at the age of 8 months. It was found that animals carrying the more common heterozygous TC genotype in the T878C substitution (p.Ala293Val., 26:21272422, rs41255693) in the SCD gene had a higher body weight compared to carriers of homozygous variants of the TT and CC genotypes by 2. 5 and 17%, respectively, as well as among the entire population studied for the two studied genes. Animals carrying the homozygous AA genotype of the c.408A>G substitution in the FABP4 gene had the highest body weight among all the studied individuals for this gene, while the carriers of the AG genotype were distinguished by the smallest weight. The studied polymorphisms of the SCD and FABP4 genes have a highly significant relationship with live weight in Kalmyk bulls and can be used as DNA markers in Kalmyk cattle breeding.
Efecto cicatrizante en incisiones periodontales por extracto hidroalcohólico de Morinda citrifolia
Authors: Ramos Meza Carlos Samuel , Corzo Palomo Erika Eleana , Olivera Trujillo Luis Alberto , Valencia Martinez Juan Carlos , Gutierrez Acuña Yeni 
Published: August 2023

Los tratamientos periodontales implican cortes y sangrado de la mucosa gingival; la Morinda citrifolia, específicamente sobre los fragmentos encargados de la cicatrización (plaquetas), tiene un efecto más significativo en los procesos curativos de las lesiones. Objetivo. Identificar el potencial cicatrizante de los extractos hidroalcohólicos de Morinda citrifolia (noni peruano) en los procesos regenerativos de las incisiones periodontales al 70% a diversas concentraciones (1%; 5; y 10%) y su efecto coadyuvante acelerador en la vía oral como curación de tejidos. Materiales y Métodos. Se realizó una investigación aplicada, bajo el diseño experimental. Para ello, se llevó a cabo un estudio previo para el análisis farmacognóstico, porcentaje de humedad, pruebas de solubilidad y el análisis fitoquímico cualitativo para garantizar que el análisis farmacológico y la prueba experimental se completaran adecuadamente. Se administraron dosis a cinco ratas albinas macho Holtzman divididas en cuatro grupos a los cuales se les aplicó las concentraciones en cantidades de 0,5 ml dos veces al día en la incisión, la cual se evaluó durante siete días para obtener parámetros específicos, como infección, tono de piel gingival, cierre de heridas, reducción del tamaño de la incisión y porcentaje de curación. Resultados. Indicaron que todos los grupos que se le suministró el extracto hidroalcohólico al 70% en varias concentraciones mejoró su actividad curativa al reducir el tamaño de la incisión en la encía al séptimo día, donde resultó que la mejor concentración fue del 5% en comparación con las otras concentraciones (1% y 10%). Investigación que indica la eficacia de la Morinda citrifolia peruana como acelerador del proceso de curación en la terapia periodontal.
Use of Ultrasound-Guided Erector Spinae Plane Block in the Treatment of Patients with Dorsopathy
Authors: Свизунов О.И. , Конончук С.Н. , Малков А.Б. , Галицкая С.С. 
Published: August 2023

Цель. Оценить эффективность и безопасность применения метода ультразвук-ассистированной блокады мышцы, выпрямляющей позвоночник (УАБ МВП), при комплексном лечении дорсопатий, сопровождающихся острым или хроническим болевым синдромом. Материалы и методы. В исследование включены пациенты с дорсопатиями, которым с целью купирования болевого синдрома выполнялись блокады: УАБ МВП или паравертебральная блокада по анатомическим ориентирам (ПВБ). Пациенты были распределены для сравнения на две клинические группы в зависимости от применяемого метода блокады. Результаты. Исследование доказало, что использование УАБ МВП не уступает в эффективности ПВБ, является безопасным методом купирования болевого синдрома у пациентов с дорсопатиями, но при этом сохраняет свой лечебный эффект более продолжительное время. Заключение. УАБ МВП является высокоэффективным методом комплексного лечения пациентов с дорсопатиями.
Purpose. To assess the efficacy and safety of ultrasound-guided erector spinae plane block (USG ESPB) in the complex treatment of dorsopathies accompanied by acute or chronic pain syndrome. Materials and methods. The study included patients with dorsopathies who underwent blocks in order to relieve pain: USG ESPB or paravertebral block according to anatomical landmarks (PVB). Patients were divided into two clinical groups for comparison, depending on the applied block method. Results. The study proved that the use of USG ESPB is as effective as PVB being a safe method of pain relief in patients with dorsopathies, while retaining its therapeutic effect for a longer time. Conclusion. USG ESPB is a highly effective method of complex treatment of patients with dorsopathies.
Determining the Strategies Used by Teachers Working with Students with Intellectual Disabilities in Teaching Reading Comprehension
Authors: GÜNLÜ Yasin , ÖZGÜR YILMAZ Çağla 
Published: August 2023

The general purpose of this study was to define the strategies used by teachers working with
students with intellectual disabilities in teaching them reading comprehension. In line with
this general purpose, the study sought to find out which cognitive and metacognitive
strategies these teachers working used before, during and after reading in reading
comprehension activities in the classroom. The study used semi-structured interviews, one
of the data collections techniques employed in qualitative studies. Interviews were
conducted with 13 special education teachers working with students with mild intellectual
disabilities. These students are educated at a special education and practice school high
school. The data obtained from the teachers were analyzed using descriptive analysis. The
findings obtained as a result of this analysis showed that special education teachers used a
limited number of strategies in teaching reading comprehension.
Empowering Athletes with AI and Blockchain: A New Era of Personalized Training, Secure Data Management, and User Engagement
Authors: Bodemer Oliver 
Published: August 2023

<p>The convergence of blockchain technology and artificial intelligence (AI) in sports applications presents a revolutionary approach to enhancing sports experiences, optimizing performance, and personalizing user interactions. This article offers an in-depth review of the applications, algorithms, challenges, and future directions of blockchain and AI in sports applications. We delve into the use of AI algorithms and blockchain technology in sports apps to create secure, transparent platforms for transactions, analyze performance data, provide personalized insights, and foster fan engagement. The article scrutinizes the scientific underpinnings of blockchain and AI-enhanced sports apps, discussing the personalization of user experiences, performance analysis using AI and blockchain-powered tools, fan engagement strategies, ethical implications and data privacy, case studies and empirical evidence, challenges, and recommendations for further research. We underscore the potential of blockchain and AI in revolutionizing sports apps, offering tailored experiences, and optimizing user engagement. The article concludes by pinpointing areas for future research, including advanced data analytics, explainable AI models, ethical considerations, collaboration, longitudinal studies, optimization of user experiences, human-AI interaction, and generalization to diverse populations. By exploring these research avenues, the field of blockchain and AI-enhanced sports applications can continue to evolve, supporting fans, athletes, and coaches in achieving their goals and unlocking new dimensions of sports experiences. </p>
CMOS Analog-to-Digital Converter for Perovskite PV Sensing Applications
Authors: Mokogwu Francis , Marzuki Arjuna , Ng Annie , Ukaegbu Ikechi 
Published: August 2023

<p> An 8-bit asynchronous single-ended Successive Approximation Register (SAR) Analog-to-Digital Converter (ADC) for the realization of a perovskite photovoltaic (PV) sensing application is presented. Various techniques have been proposed to enhance speed and power efficiency. A bootstrap transmission gate-based sample and hold circuit is proposed to improve sampling linearity and reduce power consumption. The sample and hold circuit is configured to operate at a 90% duty cycle, hence, giving it enough time for the conversion. A two-stage latch dynamic comparator is implemented to ensure high-speed and low power consumption. The SAR ADC also implements an asynchronous SAR logic block, controlled by an internal clock, which eliminates the need for an external clock. The proposed SAR ADC was designed in a UMC 180nm CMOS technology. The SAR ADC is tested with a sinusoidal analog input of 500 mV at 10 kHz frequency and a 4 MHz input clock frequency. The SAR ADC consumes a power of 2.67 mW at a supply of 1.5 V. The proposed ADC is an important unit for application in the fast growing perovskite-based PV industry. </p>
Unsupervised Domain Adaptation with Debiased Contrastive Learning and Support-Set Guided Pseudo Labeling for Remote Sensing Images
Authors: Biswas Debojyoti , Tesic Jelena 
Published: August 2023

<p>Here, we address the challenge of generalizing object detection and labeling in remote sensing data from one dataset to another. It is the variability in different altitudes, geographical variances, weather conditions, and object size across datasets that state-of-the-art DNN largely fails to generalize. Contrastive-based unsupervised domain adaptation attempts to bridge the gap by producing discriminating features for frames and instances across different datasets, and we have shown some progress on the domain alignment on local, global, and instance-aware features for remote sensing data. In this research, we propose using support-guided pseudo-labeling on the target domain instances to enable instance domain adaptation on the source and target datasets. Next, we introduce the contrastive loss function with multiple positive examples to make the model more generalized of the variable appearance of a particular class over images and domains. Also, we proposed debiased contrastive learning based on class probabilities to address the challenge of false negatives in the unsupervised framework. We show the advantages of the proposed model on satellite (DIOR and DOTA2.0) and drone (Visdrone and UAVDT) image datasets. <br>
</p>
Virtual Power-Based Technique for Enhancing the Large Voltage Disturbance Stability of HV Grid-Forming Converters
Authors: Laba Yorgo , Bruyère Antoine , Colas Frédéric , Guillaud Xavier 
Published: August 2023

<p>Grid-forming control plays an essential role in the modernization of HV electrical transmission grids, particularly in mitigating challenges imposed by large voltage disturbances. In this context, the concept of virtual power has gained prominence as a potential approach that improves stability following such disturbances. This paper illustrates the use of virtual power method in enhancing the large disturbance stability given by the grid-forming control. An adaptive virtual impedance is also proposed to further improve system dynamics. The methods are evaluated through large disturbance stability analysis and time-domain simulations. </p>
Multi-modal Contrastive Learning for Crop Classification Using Sentinel2 and Planetscope
Authors: Patnala Ankit 
Published: August 2023

<p>Remote sensing has enabled large-scale crop classification to understand agricultural ecosystems and estimate production yields. Since a few years, machine learning is increasingly used for automated crop classification. However, in most approaches the novel algorithms are applied to custom datasets containing information of few crop fields covering a small region and this often leads to models that lack generalization capability. In this work, we propose a multi-modal contrastive self-supervised learning approach to obtain a pre-trained model for crop-classification without the use of labeled data. Such multi-modal self-supervised learning exploits the synergies of different data sources to obtain a richer representation of the data. We build our analysis by adapting the DENETHOR dataset developed for a part of Eastern Germany to our usecase. We use the publicly available Sentinel2 and commercial Planetscope data. While Sentinel2 has higher spectral resolution, Planetscope has finer spatial resolution. For an end-user application, only one source is required. In this work, we analyze and compare the performance of our multi-modal self-supervised model against the uni-modal contrastive self-supervised model using the SCARF algorithm. In addition, we also compare our multi-modal self-supervised model with a supervised model. We find that our multi-modal pre-trained model surpasses the uni-modal and supervised models in almost all test cases.</p>
Legenda Raja Datuk Nabolon Pada Masyarakat Batak Toba : Analisis Psikosastra
Authors: Silitonga Franciskus Marshall C , Sinaga Warisman 
Published: August 2023

Artikel ini membahas tentang Legenda Raja Datuk Nabolon Pada Masyarakat Batak Toba : Analisis Psikosastra. Dalam Masyarakat Desa Sipahutar, Kec. Sipahutar, Kab. Tapanuli Utara terdapat legenda Raja Datuk Nabolon yang menceritakan tentang pembagian harta warisan. Artikel ini bertujuan menguraikan unsur intrinsik dan menguraikan faktor yang memengaruhi psikis tokoh utama dalam legenda Raja Datuk Nabolon. Dalam menyelesaikan artikel ini penulis menggunakan teori psikoanalisis yang dikemukakan oleh Sigmund freud yang mengatakan bahwa teori psikoanalisis berhubungan dengan fungsi dan perkembangan mental manusia dengan metode deskriftif kualitatif. Untuk menunjang hasil dari artikel ini penulis menggunakan metode pengumpulan data dengan cara (1)wawancara dengan informan, (2) obsevasi dan (3) dokumentasi. Adapun hasil yang ditemukan dalam artikel ini bahwa mitos Raja Datuk Nabolon diterima dengan baik oleh masyarakat setempat. Menurut temuan tersebut, penduduk setempat memahami bahwa berbagi kekayaan orang tua diantara saudara adalah inti dari tradisi Raja Datuk Nabolon, dan legenda ini berpotensi mengirimkan pesan positif. Namun, survei menemukan bahwa hanya orang tua yang percaya pada kisah Raja Datuk Nabolon. Cerita rakyat seputar Raja Datuk Nabolon dijunjung tinggi dengan harapan dapat menginspirasi generasi mendatang. Desa Sipahutar, Kecamatan Sipahutar, Kabupaten Tapanuli Utara memiliki peraturan perundang-undangan tersendiri yang harus diikuti oleh setiap masyarakat.
Isolation of biosurfactant/bioemulsifier from Saccharomyces cerevisiae by different treatment
Authors: Haider Raham Duaa , Nazar Mahmood Nibras 
Published: August 2023

Biosurfactant are amphiphilic compound have been increasingly attracting the attention of the scientific community as promising candidates for the replacement of a number of synthetic surfactants. The aim of this study is to extraction of Biosurfactant from Saccharomyces cerevisiae by using three treatment (absolute ethanol , ammonium sulphate and heating). The present study clearly showed that , the treatment with boiling to 30 min was very effect to extract the biosurfactant from S. cerevisiae best than other treatments with high emulsification index and surface activity where were 81.08% and 20 mm , respectively
Synthesis and characterization of some thioether compounds by thiol-ene click chemistry
Authors: Abdulraoof saleh  , Raed k. Zaidan  
Published: August 2023

In this study, some thioether compounds were prepared by thiol-ene click reaction using cheap starting materials from natural source or plastic waste such as limonene from orange peel, and styrene by thermal degradation (cracking) of plastic waste like spoon and fork plastic, and different reaction conditions were achieved, some starting material did not need any catalyst or heat like limonene reacts with thioglycolic acid to give 2-(4-methylcyclohex-3-en-1-yl)propyl)thio)acetic acid , where the reaction was exothermic and very fast, while the styrene need the catalyst such as water or glycerol to start the reaction with thioglycolic acid through nucleophilic addition to give 2-(phenethylthio)acetic acid . The synthesized thioether compounds were prepared in high yield through anti-Markonickov rule at room temperature and diagnosed by FT- IR and H-NMR .