bluuebunny/crossref_metadata_2025_split huggingface dataset:
BCL9 is a risk factor of neck lymph nodes metastasis and correlated with immune cell infiltration in papillary thyroid carcinoma
Authors: Zhang Rui , Gui Zhengwei , Zhao Jianguo , Zhu Di , Zhao Lu 
Published: July 2023

Abstract
Purpose
BCL9 contributed to tumor progression and metastasis in various tumors, whereas, the role of BCL9 in papillary thyroid cancer (PTC) hasn’t been investigated.
Methods
We acquired PTC gene expression data from The Cancer Genome Atlas (TCGA) databases. 59 PTC tissues were applied to validate the clinical significance of BCL9. Cell experiments were applied to investigate the role of BCL9. Bioinformatics analysis were employed to investigate the biological functions of BCL9.
Results
We found that BCL9 was higher expressed (P ༜ 0.05) and an independent risk factor for lymph node metastasis (OR = 3.770, P = 0.025), as well as associated with poorer progression free survival (PFS) (P = 0.049) in PTC. BCL9 knockdown inhibited proliferation and invasion of PTC cells. BCL9 was positively associated with the key genes of Wnt/β-catenin and MAPK pathway by Co-expression analysis. GO, KEGG and GSEA analysis showed BCL9 might participated in PPAR, cAMP, and focal adhesion pathway. CIBERSORT analysis found BCL9 was negatively associated with CD8 + T cells and NK cells infiltration and positively with PD-L1 expression.
Conclusion
Therefore, BCL9 was associated with lymph node metastasis and shorter PFS of PTC, due to promotion of PTC cell proliferation and invasion, activation of Wnt/β-catenin and MAPK pathway, inhibition of CD8 + T and NK cells infiltration, and promotion of PD-L1 expression.
Air Pollution, Health Expenditures and Multilevel Medical Insurance Systems: Evidence from China
Authors: Wang Ennan , Zhu Minglai , Lin Yisha , Xi Xiaoyu 
Published: July 2023

Abstract

Background
Air pollution affects residents' health to varying extents according to differences in socioeconomic status. However, there has been a lack of research on whether air pollution contributes to unfair health costs.
Methods
In this research, data from the Labour Force Dynamics Survey are matched with data on PM2.5 average concentration and precipitation, and the influence of air pollution on the health expenditures of residents is analysed with econometric methods involving a two-part model, instrument variables and moderating effects.
Results
The findings reveal that air pollution significantly impacts residents’ health costs and leads to low-income people face health inequality. Specifcally, the empirical evidence shows that air pollution has no significant influence on the probability of residents’ health costs (β =0.021, p=0.770) but that it increases the amount of residents’ total outpatient costs (β =0.379, p<0.006), reimbursed outpatient cost (β =0.453, p<0.044)and out-of-pocket outpatient cost (β =0.362, p<0.048). The heterogeneity analysis of income indicates that low-income people face inequality due to health cost inflation caused by air pollution, their total and out-of-pocket outpatient cost significantly increase with PM2.5 (β =0.417, p=0.013; β =0.491, p=0.020). Further analysis reveals that social basic medical insurance does not have a remarkable positive moderating effect on the influence of air pollution on individual health inflation (β =0.021, p=0.292), but supplementary medical insurance for employees could reduce the effect of air pollution on low-income residents’ reimbursed and out-of-pocket outpatient cost (β =-1.331, p=0.096; β=-2.211, p=0.014).
Conclusion
The study concludes that air pollution increases the amount of residents’ outpatient cost and has no significant effect on the incidence of outpatient cost. However, air pollution has more significant impact on the low-income residents than the high-income, which indicates that air pollution leads to the inequity of medical cost. Additionally, the supplementary medical insurance reduces the inequity of medical cost caused by air pollution for the low-income employees.
Long-term survival analysis of microwave ablation for hepatocellular carcinoma comforming to the Milan crititia: primary versus recurrent HCC
Authors: Zhang Jing , Guo Guanya , Li Tao , Guo Changcun , Han Ying , Zhou Xinmin 
Published: July 2023

Abstract
Background
Whether microwave ablation (MWA) is as effective in initial hepatocellular carcinoma (IHCC) as in recurrent HCC (RHCC) is unclear.We aim to compare the long-term outcomes for IHCC and RHCC conforming to the Milan criteria.
Methods
In this retrospective study, 425 Milan-eligible patients (294 IHCCs, 131 RHCCs) who underwent MWA from January 2008 to November 2021 were included. All the patients with RHCC had MWA as initial treatment. Propensity-score matching (PSM) analysis was used to assess the overall survival (OS) and recurrence-free survival (RFS) between IHCC and RHCC.
Results
After PSM, OS in IHCC was better than in RHCC, with OS rates at 1, 3, 5, and 10 years in IHCC were 97.5%, 79.7%, 54.6% and 38.4%, respectively, and in RHCCs were 94.1%, 69.2%, 42.4% and 5.6%, respectively. However, subgroup analyses suggested that there were no significantly differences in OS between IHCC and RHCC in patients with solitary HCC ≤ 3.0 cm, AFP ≤ 200 ng/mL, or ALBI grade 1. Patients with RHCC had worse RFS than those with IHCC in the entire and PSM cohorts, as well as in the subgroup analyses. No association between time to recurrence with OS and RFS was identified in patients who received repeat MWA.
Conclusions
Although RHCC patients had worse prognosis than IHCC patients, MWA could be used as an effective treatment for RHCC as in patients with single small tumor, lower AFP level, and good liver function reserve regardless of time to recurrence. Close surveillance should be taken in RHCC patients after MWA.
Stability analysis of riverbanks with a dual structure under water–root–soil coupling
Authors: Hao Youzhi , Jia Dongdong , Zhang Xingnong , Shang Qin , Zhu Hongsheng , Fei Xiaoxin , Yang Jun , Wu Lei , Chen Changying 
Published: July 2023

Abstract

The collapse mechanism of dual-structure vegetation riverbanks at different water levels is unclear. A method for calculating the critical collapse width of a dual-structure vegetation bank under different failure modes that consider the variations in river and groundwater levels and the influence of vegetation roots is proposed. Combined with the influence of flow lateral erosion and slope toe accumulation, a calculation model of riverbank stability was established. The results show that shear failure is the main failure mode when the cohesive soil layer on a dual-structure bank is thick, and the critical collapse width of the bank with root soil is higher than that of the soil bank. The critical collapse width of the bank varied with the water level during different water level periods. Compared with a soil riverbank, a rooted soil riverbank can significantly prolong the bank collapse time. The collapse width of a soil bank without vegetation roots is smaller than that of a rooted soil bank, and the cumulative collapse width is related to calculation time. The greater the thickness of rooted soil, the slower the decay rate of bank stability under water flow erosion.
Hybrid electrolysis and membranes system for apple packing houses water treatment
Authors: Carpes Vanessa Maria , Rubert Aline , Graciola Samarah , Barbosa Brião Vandré , Hemkemeier Marcelo 
Published: July 2023

Abstract

The apple industry uses high flows of potable quality water to transport and clean the apple, which is regularly contaminated. Thus, it is necessary to implement an efficient water treatment system during the industrial process, providing reductions in the intake and release flows. A hybrid system was developed by applying the electrolytic treatment by electrocoagulation using a batch process (Step 1) and a continuous process (Step 2), followed by a microfiltration membrane separation (MSP) process (Step 3). The optimal conditions for removal of organic matter, chemical oxygen demand, total suspended solids (TSS), turbidity, color, and fungi obtained in Step 1 were a hydraulic detention time of 40 min, stirring at 40 rpm, current density of 20 A/m2, pH of 8.00, and temperature of 10 °C. These findings led to a successful implementation in Step 2, which evolved into Step 3, where tests in the combined continuous electrolytic reactor together with MSP showed significant removal rates, notably reaching up to 54% organic matter (OM) removal, 72% chemical oxygen demand (COD) removal, 83% TSS removal, 92% haze and color removal, and 100% mildew removal. The hybrid system proved to be a promising alternative for implementation in the processing industry, minimizing environmental impacts and costs.
How can Fullerenes Help in the Treatment of Diseases? A Review Article
on Pharmaceutical Usage of Fullerenes as Carriers
Authors: Masoomzadeh Salar , Gholikhani Tooba , Aminroaia Paria , Taghvimi Arezou , Javadzadeh Yousef 
Published: July 2023

Abstract:
Drug degradation is a process that can render pharmaceuticals inactive without causing
any visible distortion. This can disrupt the therapeutic process, and on occasion, when the process
produces toxic metabolites, it can have much more fatal consequences. Light is one of the most
significant components that might cause deterioration, and several attempts have been made to improve
and increase the practical photosensitizing of nano-scaled pharmaceuticals. Considering this,
the insolubility and aggregating qualities of fullerenes have received significant attention. Fullerene
is considered to have a unique carbon structure. In order to gain improved water solubility and
biocompatible properties, fullerenes have been combined with water-soluble, biodegradable, and
adjustable polymers. More specifically, these linkers exhibit increased tumor cell identification and
greater tumor cell suppression when linked to therapeutic ligands (tumor-targeting) or stimuliresponsive
polymers. According to scientific studies, fullerene-drug combinations can be used in
certain complex diseases, like infectious and viral types. Several studies have combined fullerenes
into nano-emulsions or liposomes for various pharmacological objectives. In the current work,
fullerene/polymer nanomaterials are discussed for potential therapeutic techniques for the treatment
of various diseases, particularly cancer and AIDS. According to the research studies, fullerene
is a suitable element with outstanding physical and chemical properties that has a wide range
of potential applications in the pharmaceutical industry, including drug delivery system design,
photodynamic cancer therapy, and antioxidant therapy.
A Profound Insight into the Structural Modification of Natural Bioactive
Compounds Containing Piperazine Moiety: A Comprehensive Review
Authors: Chopra Bhawna , Saini Neha , Dhingra Ashwani K. 
Published: July 2023

Abstract:
Piperazine is the heterocyclic nucleus and exhibits significant biological potential such
as antipsychotic, antidepressant, antihistamine, anticancer, anti-anginal, cardioprotective, antiviral,
and anti-inflammatory activity. As a result, it had been considered a crucial structural component in
the majority of the therapeutic medications that were already on the market. Other issues that limit
its use include solubility, limited bioavailability, cost-effectiveness, and a mismatch between the
drug's pharmacokinetic and pharmacodynamic profiles. Literature describes structural modification
in the piperazine moiety to create novel derivatives or analogues to solve the issues with currently
marketed medications. Nature provides various bioactive components having piperazine nuclei in
their core structure. The present review describes the potential of the piperazine nucleus present in
natural bioactive components. So the study concludes that it is vital to concentrate on the structural
characteristics of this scaffold, which opens the way for future research and may benefit pharmaceutical
companies as well as medicinal chemists.
Pengaruh Tingkat Inflasi, Suku Bunga BI, dan Pertumbuhan Ekonomi Terhadap Pembiyaan Murabahah pada Bank Syariah di Indonesia ( Periode Januari 2013 – Desember 2017 )
Authors: Perdana Khori , Hamzah Emilia , Lubis Paulina 
Published: July 2023

Penelitian ini bertujuan untuk menganalisa pengaruh Inflasi, Suku Bunga Bank Indonesia, dan Pertumbuhan ekonomi terhadap Pembiayaan Murabahah pada bank syariah di Indonesia. Data yang digunakan adalah data Time Series periode Januari 2013– Desember 2017, yang bersumber dari Statistik Perbankan Indonesia. Untuk menganalisis, penulis menggunakan metode Regresi Linier Berganda. Hasil penelitian ini menunjukkan bahwa variabel Inflasi, Suku Bunga Bank Indonesia, dan Pertumbuhan ekonomi berpengaruh signifikan secara parsial dan simultan terhadap Pembiayaan Murabahah. Dalam penelitian ini diketahui bahwa Inflasi berpengaruh signifikan positif terhadap Pembiayaan Murabahah. Sedangkan Suku Bunga Bank Indonesia, dan pertumbuhan ekonomi berpengaruh signifikan negatif terhadap Pembiayaan Murabahah.
Kata Kunci : Pembiayaan Murabahah, Inflasi , Suku Bunga BI , Pertumbuhan Ekonomi
Aktivitas Antimikroba Jamur Tiram Putih (Pleurotus ostreatus AL1) terhadap Candida albicans dan Escherichia coli
Authors: Mustary Mardiyah , Alhidayatullah Alhidayatullah , Nurhalisa Nurhalisa 
Published: July 2023

Infection is one of the many health problems that over time develop. The study entitled "white oyster fungal activity (Pleurotus ostreatus AL1) against the Candida albicans and Escherichia coli." One plant that can be used as a traditional medicine is the white oyster mushroom (Pleurotus ostreatus AL1). Aimed at identifying antimicrobial activity in the fungi and pathogenic bacteria. Isolates are made by insulating the oyster mold by medium ASK, and resistance tests are conducted using diffusion methods. This study suggests that white oyster mushrooms (Pleurotus ostreatus AL1) toward Escherichia coli. Studies show that white oyster mushrooms have a resistance test against Escherichia coli but have no resistance activity against the Candida albicans. The unbounded activity of white oyster mushrooms against E. coli media to create a clear zone with an average diameter to replicas a, b, c, and d, respectively, is 16. 5, 15. 5, 17, and 15. 5 mm.AbstrakInfeksi merupakan salah satu masalah dalam bidang kesehatan yang dari waktu ke waktu terus berkembang. Penelitian dengan judul “Aktivitas Antimikroba Jamur Tiram Putih (Pleurotus ostreatus AL1) terhadap Candida albicans dan Escherichia coli”. Salah satu makhluk hidup yang dapat digunakan sebagai obat tradisional adalah Jamur Tiram Putih (Pleurotus ostreatus AL1). Yang bertujuan untuk mengetahui adanya aktivitas antimikroba terhadap jamur dan bakteri patogen. Proses isolat dilakukan dengan mengisolat jamur tiram dengan medium ASK, dilakukan uji daya hambat menggunakan metode difusi. Hasil penelitian ini menunjukkan bahwa Jamur Tiram Putih (Pleurotus ostreatus AL1) terhadap Escherichia coli. Hasil penelitian menunjukkan bahwa jamur tiram putih memiliki uji daya hambat terhadapa Escherichia coli namun tidak memilki aktivitas daya hambat terhadap Candida albicans. Aktivitas daya hambat jamur tiram putih terhadap E. coli pada media agar cawan Na menghasilkan zona bening dengan diameter rata- rata pada replika A, B, C, dan D, masing- masing adalah 16. 5; 15. 5; 17; dan 15. 5 mm
Medium- and Long-Term Prediction of Polar Motion Using Weighted Least Squares Extrapolation and Vector Autoregressive Modeling
Authors: Lei Yu , Zhao Danning , Guo Min 
Published: July 2023

ABSTRACT
This article presents the application of weighted least squares (WLS) extrapolation and vector autoregressive (VAR) modeling in polar motion prediction. A piecewise weighting function is developed for the least squares (LS) adjustment in consideration of the effect of intervals between observation and prediction epochs on WLS extrapolation. Furthermore, the VAR technique is used to simultaneously model and predict the residuals of x
p, y
p pole coordinates for WLS misfit. The simultaneous predictions of x
p, y
p pole coordinates are subsequently computed by the combination of WLS extrapolation of harmonic models for the linear trend, Chandler and annual wobbles, and VAR stochastic prediction of the residuals (WLS+VAR). The 365-day-ahead x
p, y
p predictions are compared with those generated by LS extrapolation+univariate AR prediction and LS extrapolation+VAR modeling. It is shown that the x
p, y
p predictions based on WLS+VAR taking into consideration both the interval effect and correlation between x
p and y
p outperform those generated by two others. The accuracies of the x
p predictions are 13.97 mas, 18.47 mas, and 20.52 mas, respectively for the 150-, 270-, and 365-day horizon in terms of the mean absolute error statistics, 36%, 24.8%, and 33.5% higher than LS+AR, respectively. For the y
p predictions, the 150-, 270-, and 365-day accuracies are 15.41 mas, 21.17 mas, and 21.82 mas respectively, 27.4%, 11.9%, and 21.8% higher than LS+AR respectively. Moreover, the absolute differences of the WLS+VAR predictions and observations are smaller than the differences from LS+VAR and LS+AR, which is practically important to practical and scientific users, although the improvement in accuracies is no more than 10% relative to LS+VAR. The further comparison with the predictions submitted to the 1st Earth Orientation Parameters Prediction Comparison Campaign (1st EOP PCC) shows that while the accuracy of the predictions within 30 days is comparable with that by the most accurate prediction techniques including neural networks and LS+AR participating in the campaign for x
p, y
p pole coordinates, the accuracy of the predictions up to 365 days into the future are better than accuracies by the other techniques except best LS+AR used in the EOP PCC. It is therefore concluded that the medium- and long-term prediction accuracy of polar motion can be improved by modeling x
p, y
p pole coordinates together.
A Study to Assess the Acceptance of Doctors toward the Practice of Reusing of Cardiac Disposables in Coronary Angioplasty in a Tertiary Care Hospital
Authors: Rani Pushpi , Irshad Humera , Rashid Sajad , Nimma Satyanarayana 
Published: July 2023

Objectives:
Health-care providers are expected to deliver quality patient care cost-effectively, especially in developing countries. Medical devices labeled “single use only” should ideally not be reused but, can be considered for reuse due to their higher cost. Stringently regulated reprocessing of the single-use device provides an opportunity to do so along with the potential to have a favorable impact on environmental waste. The aim of this study is to assess the acceptance of doctors toward the practice of reusing cardiac disposables in coronary angioplasty.

Materials and Methods:
An open-ended and self-designed questionnaire was prepared and was standardized by a panel of cardiologists to assess doctors’ acceptance toward reusing cardiac disposable in coronary angioplasty. The cardiologists were interviewed individually, and the responses were analyzed.

Results:
The cardiologists were aware that the angioplasty disposables were being reused. The majority were satisfied with the sterilization of disposables and were of the opinion that it was safe for the patients. Cardiac catheters were reused 5–6 times while the balloons were reused 3–4 times. An increase in procedure time of 10–15 min was observed in 30% of the patients. There was an increase, in contrast, volume of about 40–50 mL with reused cardiac catheters and balloons which was observed in 15% of the patients. Defect in the physical integrity of the catheter, that is, tip abrasion/microfracture was observed in 1% of the patients. Deflation dysfunction of the balloon during the procedure was observed in 2% of the patients, while breakage of the balloon from the shaft and entanglement of the balloon was observed in 1% of the patients. Balloon rupture during angioplasty was observed in 8% of the patients. Around 1.5% of the patients undergoing angioplasty with reused disposables were presented with infections. Thrombosis was observed in 3% of the patients with reused disposables, and it was the most common adverse event post-angioplasty. There were cases where the patients were sent for emergency surgery/coronary artery bypass graft surgery due to balloon entanglement and about 0.1% of the patients were found to have such a complication.

Conclusion:
Cardiac disposables can be safely reused by health-care professionals, especially in developing nations due to their budget constraints, provided it is reused no more than 3–5 times and efficient methods of sterilization are observed.
Influence of Problem Based Learning Model on Students’ Mathematical Reasoning Ability
Authors: Gunawan Heri , Rifat Mohamad , Sayu Silvia 
Published: July 2023

The study aimed to determine the effect of problem-based learning models on students' mathematical reasoning abilities. The study used an experimental method with a quasi-experimental design and a posttest-only control design. The population was all classes in VIII grade at MTs Negeri 3 Mempawah in the 2019/2020 school year. The samples were students of VIII C and VIII A grades and were drawn using simple random sampling. Data collection techniques and tools were measurements that used a essay test contained indicators of mathematical reasoning abilities. After being tested in the two samples, data analysis was then carried out to test the hypothesis. Before testing the hypothesis, first, a prerequisite test was carried out, namely the normality test. Because the data are normally distributed, to test the hypothesis we used the t-test. It was obtained that tcount = 11.15 and ttable = 1.99 with α = 0.05. Because of the value of tcount> ttable, it can be concluded that the problem-based learning model affects students' mathematical reasoning abilities. Keywords: Problem based Learning, Mathematic, Reasoning Ability
THE EFFECT OF GEOGEBRA-AIDED PROBLEM BASED INSTRUCTION MODEL AND MATHEMATICAL DISPOSITION ON PROBLEM SOLVING ABILITY
Authors: Zulaiha Siti 
Published: July 2023

This research aims to determine: (1) The effect of PBI in GeoGebra Assisted Learning through problem based solving. (2) Difference of ability for solving between student’s taught by PBI in Geogebra Assisted Learning with Direct Instruction. (3) Difference of ability for solving from mathematical disposition. (4) The interaction between Learning Model and mathematical disposition. The research method that used is factorial design. The study sample in this study were students of class XI Kep A and XI Kep B. Technique of analyze data used is two way anova. From the results and analysis of data obtained the study are as follow: The effect of PBI in Geogebra Assisted Learning through problem based solving with the medium category then the result of effect size is 0,5886, there is difference significance between problem based solving with PBI in Geogebra Assisted Learning and Direct Instruction with significance result is 0,001, there is difference significance between student’s learning in high mathematical disposition and low with the significance result is 0,000, and there is significance interaction between Learning Method and Student’s mathematical disposition. Keywords: Problem Based Instruction, Geogebra Assisted Learning, mathematical disposiion, Problem Solving