bluuebunny/crossref_metadata_2025_split huggingface dataset:
The risk factors of progestational anxiety, depression, and sleep disturbance in women with recurrent pregnancy loss: A cross-sectional study in China
Authors: Wang Ting-ting , Liu Yi-lin , Hou Yue , Li Jia-po , Qiao Chong 
Published: March 2023

BackgroundThe risk factors of progestational anxiety, depression, and sleep disturbance in women with a history of recurrent pregnancy loss (RPL) remain controversial, additional study is needed to investigate the incidence and risk factors of progestational anxiety, depression, and sleep quality in RPL women.MethodsA cross-sectional study was conducted among 663 non-pregnant RPL women in Northeast China from October 2019 to July 2022. We assessed the state of anxiety, depression, and sleep quality before pregnancy using structured questionnaires, including sociodemographic characteristics, state-trait anxiety scale (STAI), center for epidemiological survey, depression scale (CES-D), Pittsburgh sleep quality index (PSQI), and symptom self-rating scale (SCL-90). Logistic regression was used to evaluate the association between sleep quality and anxiety, depression. Pearson’s correlation was used to evaluate the correlation between anxiety and depression. Multivariate logistic regression analysis was used to find the risk factors of depression symptoms. The receiver operating characteristic curve (ROC) was used to evaluate the predictive value of the model.ResultsThe incidence of state anxiety, trait anxiety, depression, and sleep disturbance in RPL women were 60.3, 51.7, 33.9, and 31.2%, respectively. The level of anxiety and depression in RPL women varied at different stages of treatment. In a longitudinal study (25 pairs), we found the level of state anxiety and trait anxiety were significantly lower after the cause was identified. Sleep disturbance is positively correlated with anxiety and depression. Logistic regression showed that the number of miscarriages ≥4 (Odds ratio (OR) = 2.268, 95%CI 1.300–3.956), Low household family income (OR = 1.613, 95%CI 1.036–2.513/OR = 2.361, 95%CI 1.095–5.092), interval since last miscarriage &lt;6 months (OR = 2.154, 95%CI 1.246–3.726) and sleep disturbance (OR = 5.523, 95%CI 3.542–8.614) were associated with the occurrence of depressive symptoms. At the same time, anxiety can be used as a predictor of depression.ConclusionRecurrent pregnancy loss women have a certain degree of anxiety, depression, and sleep disturbance. Education level, interval since the last miscarriage &lt;6 months, and sleep disturbance are risk factors for anxiety and depression. A history of pregnancy loss after 14 weeks and no living birth are also closely related to anxiety. Therefore, it is necessary to pay close attention to the psychological state of RPL women and provide appropriate psychosocial support to reduce the occurrence of negative emotions.
Health-related quality of life among patients with treated alcohol use disorders, schizophreniform disorders or affective disorders and the influence of flexible and integrative psychiatric care models in Germany (PsychCare)
Authors: Neumann Anne , Soltmann Bettina , Kliemt Roman , Weinhold Ines , Schmitt Jochen , Pfennig Andrea , Baum Fabian 
Published: March 2023

IntroductionFlexible and integrated treatment options (FIT) have been established in German psychiatric hospitals to enhance continuous and patient-centered treatment for patients with mental disorders. We hypothesized that patients with experience in FIT treatment showed higher health-related quality of life (HRQoL) and comparable symptom severity compared with patients treated as usual (TAU). Further, we expected that some sub-dimensions of HRQoL determined HRQoL results clearer than others, while certain factors influenced HRQoL and symptom severity stronger in the FIT compared to the TAU group. In addition, we hypothesized that HRQoL is correlated with symptom severity.MethodsWe undertook a controlled, prospective, multicenter cohort study (PsychCare) conducted in 18 psychiatric hospitals in Germany, using the questionnaires Quality of Well Being Self-Administered (QWB-SA) (HRQoL) and Symptom-Checklist-K-9 (SCL-K-9) (symptom severity) at recruitment (measurement I) and 15 months later (measurement II). We assessed overall HRQoL (measured in health utility weights (HUW) and symptom severity score for patients from FIT and TAU treatment. We investigated the QWB-SA dimensions and separated the results by diagnosis. We used beta regressions to estimate the effect of multiple co-variates on both outcomes. To investigate the correlation between HRQoL and symptom severity, we used Pearson correlation.ResultsDuring measurement I, 1,150 patients were recruited; while 359 patients participated during measurement II. FIT patients reported higher HUWs at measurement I compared to TAU patients (0.530 vs. 0.481, p = 0.003) and comparable HUWs at measurement II (0.581 vs. 0.586, p = 0.584). Symptom severity was comparable between both groups (I: 21.4 vs. 21.1, p = 0.936; II: 18.8 vs. 19.8, p = 0.122). We found lowest HRQoL and highest symptom severity in participants with affective disorders. HRQoL increased and symptom severity decreased over time in both groups. The QWB-SA dimension acute and chronic symptoms was associated with highest detriments in HRQoL. We identified risk/protective factors that were associated with lower quality of life and higher symptom severity in both groups. We confirmed that HRQoL was negatively associated with symptom severity.DiscussionHealth-related quality of life (during hospital treatment) was higher among patients treated in FIT hospitals compared to patients in routine care, while symptom severity was comparable between both groups.
Toward the strengthening of radioprotection during mammography examinations through transparent glass screens: A benchmarking between experimental and Monte Carlo simulation studies
Authors: ALMisned Ghada , Elshami Wiam , Rabaa Elaf , Kilic G. , Ilik E. , Sen Baykal Duygu , Ene Antoaneta , Tekin H. O. 
Published: March 2023

IntroductionA lead-acrylic protective screen is suggested to reduce radiation exposure to the unexposed breast during mammography. The presence of toxic lead in its structure may harm the tissues with which it comes in contact. This study aimed to design a CdO-rich quaternary tellurite glass screen (C40) and evaluate its efficiency compared to the Lead-Acrylic protective screen.MethodsA three-layer advanced heterogeneous breast phantom designed in MCNPX (version 2.7.0) general-purpose Monte Carlo code. Lead acrylic and C40 shielding screens were modeled in the MCNPX and installed between the right and left breast. The reliability of the absorption differences between the lead acrylic and C40 glass were assessed.Results and discussionThe results showed that C40 protective glass screen has much superior protection properties compared to the lead acrylic protective screen. The amount of total dose absorbed in the unexposed breast for C40 was found to be much less than that for lead-based acrylic. The protection provided by the C40 glass screen is 35–38% superior to that of the Lead-Acrylic screen. The C40 offer the opportunity to avoid the toxic Pb in the structure of Lead-Acrylic material and may be utilized for mammography to offer superior radioprotection to Lead-Acrylic and significantly lower the dose amount in the unexposed breast. It can be concluded that transparent glass screens may be utilized for radiation protection purposes in critical diagnostic radiology applications through mammography.
Co-designing, measuring, and optimizing innovations and solutions within complex adaptive health systems
Authors: Pinero de Plaza Maria Alejandra , Yadav Lalit , Kitson Alison 
Published: March 2023

ObjectiveTo introduce, describe, and demonstrate the emergence and testing of an evaluation method that combines different logics for co-designing, measuring, and optimizing innovations and solutions within complex adaptive health systems.MethodWe describe the development and preliminary testing of a framework to evaluate new ways of using and implementing knowledge (innovations) and technological solutions to solve problems via co-design methods and measurable approaches such as data science. The framework is called PROLIFERATE; it is initially located within the ecological logic: complexity science, by investigating the evolving and emergent properties of systems, but also embraces the mechanistic logic of implementation science (IS) (i.e., getting evidence-based interventions into practice); and the social logic, as the study of individuals, groups, and organizations. Integral to this logic mixture is measuring person-centered parameters (i.e., comprehension, emotional responses, barriers, motivations, and optimization strategies) concerning any evaluated matter across the micro, meso, and macro levels of systems. We embrace the principles of Nilsen's taxonomy to demonstrate its adaptability by comparing and encompassing the normalization process theory, the 2 × 2 conceptual map of influence on behaviors, and PROLIFERATE.ResultsSnapshots of ongoing research in different healthcare settings within Australia are offered to demonstrate how PROLIFERATE can be used for co-designing innovations, tracking their optimization process, and evaluating their impacts. The exemplification involves the evaluation of Health2Go (the design and implementation of an innovative procedure: interdisciplinary learning within an allied health service—community-based) and RAPIDx_AI (an artificial intelligence randomized clinical trial being tested to improve the cardiac care of patients within emergency departments—tertiary care).ConclusionPROLIFERATE is one of the first frameworks to combine ecological, mechanistic, and social logic models to co-design, track, and evaluate complex interventions while operationalizing an innovative complexity science approach: the knowledge translation complexity network model (KT-cnm). It adds a novel perspective to the importance of stakeholders’ agency in the system by considering their sociodemographic characteristics and experiences within different healthcare settings (e.g., procedural innovations such as “interdisciplinary learning” for Health2Go, and tech-enabled solutions such as RAPIDx_AI). Its structured facilitation processes engage stakeholders in dynamic and productive ways while measuring and optimizing innovation within the complexities of health systems.
Development and tolerability of a novel virtual- and proprioception-based car crash simulator as a new research tool in motor vehicle trauma research
Authors: Lukacs Michael J. , Babin Mathias , Dickey James P. , Melling C. W. James , Walton David M. 
Published: March 2023

Purpose: Investigations of causal theories of neck pain (NP) following motor vehicle crashes (MVC) has been difficult, as simulation is limited. Thus, we sought to evaluate tolerability to a novel virtual reality (VR)-based road collision simulator and screen for adverse reactions.Materials and Methods: Cross-sectional study. 25 healthy participants were exposed to a novel VR-based rear-end MVC with a small perturbation (0.2 g). The Simulator Sickness Questionnaire (SSQ) and Presence Questionnaire (PQ) were measured post-exposure and adverse reactions were recorded.Results: The system was well tolerated with no adverse reactions, however one participant reported NP the following day not lasting longer than 48 h. Participants reported low levels of simulator sickness (mean SSQ = 23.49 ± 21.98, range = 0.00 to 89.76; max score = 235.62), while presence (mean PQ = 91.04 ± 14.08, range = 54.00 to 112.00; max score = 133), was lower than literature recommendations.Conclusion: A VR-based road collision simulator can be safely used to explore the phenomenon of a motor vehicle crashes under controlled circumstances. Future work is needed to optimize the virtual reality environment and to investigate the effects of crash parameters.
Electronic application for rabies management improves surveillance, data quality, and investigator experience in Haiti
Authors: Schrodt Caroline A. , Dilius Pierre , Gibson Andrew D. , Crowdis Kelly , Fénelon Natael , Ross Yasmeen , Bonaparte Sarah , Gamble Luke , Lohr Frederic , Joseph Haïm C. , Wallace Ryan M. 
Published: March 2023

BackgroundIntegrated bite case management (IBCM) is a multi-sectoral response to animal-bites which reduces human and canine rabies mortality through animal quarantine, bite-victim counseling, and vaccination tracking. Haiti's national rabies surveillance program was established in 2013 using paper-based IBCM (pIBCM) with adoption of an electronic smartphone application (eIBCM) in 2018.MethodsWe evaluated the feasibility of implementing the electronic app in Haiti and compared pIBCM and eIBCM data quality collected January 2013–August 2019. Deaths prevented, cost-per-death averted, and cost-per-investigation during use of pIBCM and eIBCM were estimated using a previously validated rabies cost-effectiveness tool that accounted for bite-victim demographics; probability of acquiring rabies; post-exposure prophylaxis; and costs including training, supplies, and salaries. We compared pIBCM and eIBCM based on data comprehensiveness, completeness, and reporting efficiency. Surveys were administered to IBCM staff to evaluate the usefulness, simplicity, flexibility, and acceptability of eIBCM.ResultsOf 15,526 investigations, 79% were paper-based and 21% electronic. IBCM prevented 241 (estimated) human rabies deaths. Using pIBCM, cost-per-death averted was $2,692 and the cost-per-investigation was $21.02; up to 55 data variables were collected per investigation; data transmission took 26 days to reach national staff, and 180 days until analysis. Using eIBCM, the cost-per-death averted was $1,247 and the cost-per-investigation was $22.70; up to 174 data variables were collected per investigation; data transmission took 3 days to reach national staff, and 30 days until analysis. Among 12,194 pIBCM investigations, 55% were mappable by commune, compared to 100% of eIBCM investigations mappable by GPS. Animal case definitions were incorrectly ascribed by investigators in 5.5% of pIBCM investigations and zero for eIBCM; typically, errors were in determining probable vs. suspect case assignments. Overall, eIBCM was well-accepted by staff, who reported the app is easy-to-use, facilitates investigations, and compared to pIBCM hastens data reporting.DiscussionIn Haiti, eIBCM showed improved data completeness, data quality, and shorter notification times with minimal increase in operational cost. The electronic app is simple-to-use and facilitates IBCM investigations. Rabies endemic countries could refer to eIBCM in Haiti as a cost-effective means to reduce human rabies mortality and improve surveillance capacity.
Unification Theories: Rings, Boolean Algebras and Yang–Baxter Systems
Authors: Nichita Florin F. 
Published: March 2023

This paper continues a series of papers on unification constructions. After a short discussion on the Euler’s relation, we introduce a matrix version of the Euler’s relation, E I π+U=O. We refer to a related equation, the Yang–Baxter equation, and to Yang–Baxter systems. The most consistent part of the paper is on the unification of rings and Boolean algebras. These new structures are related to the Yang–Baxter equation and to Yang–Baxter systems.
Identification of the NAC Transcription Factor Family during Early Seed Development in Akebia trifoliata (Thunb.) Koidz
Authors: Liu Huijuan , Chen Songshu , Wu Xiaomao , Li Jinling , Xu Cunbin , Huang Mingjin , Wang Hualei , Liu Hongchang , Zhao Zhi 
Published: March 2023

This study aimed to gain an understanding of the possible function of NACs by examining their physicochemical properties, structure, chromosomal location, and expression. Being a family of plant-specific transcription factors, NAC (petunia no apical meristem and Arabidopsis thaliana ATAF1, ATAF2, and CUC2) is involved in plant growth and development. None of the NAC genes has been reported in Akebia trifoliata (Thunb.) Koidz (A. trifoliata). In this study, we identified 101 NAC proteins (AktNACs) in the A. trifoliata genome by bioinformatic analysis. One hundred one AktNACs were classified into the following twelve categories based on the phylogenetic analysis of NAC protein: NAC-a, NAC-b, NAC-c, NAC-d, NAC-e, NAC-f, NAC-g, NAC-h, NAC-i, NAC-j, NAC-k, and NAC-l. The accuracy of the clustering results was demonstrated based on the gene structure and conserved motif analysis of AktNACs. In addition, we identified 44 pairs of duplication genes, confirming the importance of purifying selection in the evolution of AktNACs. The morphology and microstructure of early A. trifoliata seed development showed that it mainly underwent rapid cell division, seed enlargement, embryo formation and endosperm development. We constructed AktNACs co-expression network and metabolite correlation network based on transcriptomic and metabolomic data of A. trifoliata seeds. The results of the co-expression network showed that 25 AtNAC genes were co-expressed with 233 transcription factors. Metabolite correlation analysis showed that 23 AktNACs were highly correlated with 28 upregulated metabolites. Additionally, 25 AktNACs and 235 transcription factors formed co-expression networks with 141 metabolites, based on correlation analysis involving AktNACs, transcription factors, and metabolites. Notably, AktNAC095 participates in the synthesis of 35 distinct metabolites. Eight of these metabolites, strongly correlated with AktNAC095, were upregulated during early seed development. These studies may provide insight into the evolution, possible function, and expression of AktNACs genes.
المسائل الصوتية في (كتاب الألفاظ) لابن السكيت (ت244هـ)
Authors: محمد رسل عباس 
Published: March 2023

لم يكن ابن السكيت من علماء النحو وذلك بشهادة من عاصره ومن أَرَخَّ له ومن نقل تلك الحادثة التي سُئلَ فيها عن وزن (نكتل) وفي ذلك دليل على ضعفه في النحو ولم يوفق أَن يحشر مع علماء النحو ، وذلك لا يمنع في كونه عالما من علماء اللغة ومن أعلم الناس باللغة والشعر.كان رحمه الله راوية ثقة ، ولم يكن بعد أبن الأعرابي مثله [i]. إن شخصية ابن السكيت كانت مثار إعجاب العلماء و يدل على ذلك كلمات الثناء والمديح التي ذكرها فيه العلماء ومن ذلك ما جاء على لسان الشيخ النجاشي فيه قال : (وكان وجهاً في علم العربية واللغة ثقة ، مصدقاً لا يطغى عليه) وانه كان من خاصّة الإمامين الجواد والهادي (عليهما السلام) ، وأشار إلى رواياته عن الإمام الجواد عليه السلام . وقال الخطيب البغدادي في تاريخه : (كان من أهل الفضل والدين ، موثوقاً بروايته ، وكان يؤدّب ولد جعفر المتوكل )[i] ينظر : معجم الأوباء : 6/2841
انعكاس المعتقدات الشعبية في ديوان الشريف الرضي
Authors: اسدی حدیث شیخ , سیاحی صادق , دادخواه حسن 
Published: March 2023

هناك صلة وطيدة بين الأدب الشعبي بعناصره المتعددة وبين حياة الناس وثقافتهم الشعبيتين ولم تزل تكوّن المعتقدات الشعبية جزءًا من ثقافة الشعوب ولغاتهم وآدابهم وإن لم تكن خالية عن الخرافات ولذلك يستفيد كبار الشعراء والكتّاب من عناصر الثقافة الشعبية بمختلف الأشكال لنقل أفكارهم. ونلاحظ أن انعكاس الثقافة الشعبية في أعمال الأدباء الذين يتمعتون بشعبية أكثر أقوى من سائر الشعراء. كذلك استخدم شعراء العصر العباسي وكتّابه معتقدات الناس العادية والشعبية كمادة لشعرهم ونثرهم ليضفوا طابعًا دينيًا وقوميًا على أعمالهم ويحصنوا ثقافة مجتمعهم وسننهم من أذى النسيان وينقلوها إلى الأجيال القادمة. إن أشعار الشريف الرضي بصفتها أحد أبرز أعمال هذا العصر مملوءة بالآداب والسنن والمعتقدات الشعبية الخاصة بهذا العصر.
الطبيعة في الشعر الأندلسي بين النزعة الذاتيّة والموضوعيّة
Authors: احمدي عبد الحمید , زاده فؤاد 
Published: March 2023

الطبيعة من المضامين الرئيسة التي تجلّت بكلّ وضوح في معظم النتاجات الأدبية، وشكّلت البناء العام للأدب الإنساني من العصور القديمة إلى يومنا هذا؛ فهي محرّك مهمّ لخيال الأديب كي يستلهم منها وحي قلمه. والمتدبّر في الآثار الأدبية التي وصلتنا من الأندلس يجد أنّ شعراءها قد اتجهوا نحو الطبيعة ومظاهرها؛ فوصفوها وصفا دقيقا، وتغنّوا بجمالها وزوايا حسنها. فهذه الدراسة تسعى و بالاعتماد على المنهج الوصفي التحليلي أن تستعرض إبداعات الأندلسيين في شعر الطبيعة، وما فيها من سمات خاصة ميّزتها عن نتاجات الشرقيين الأدبية. فشعرُ الطبيعةِ عند الأندلسيين يتراوح بين الموضوعيةِ والذاتية؛ فهم يقفون أحيانا من الطبيعة موقف المصوِّر الذي التقط صوراً من بُعدٍ، دون أن يدخلوا في صميمها ويطِلَّوا علينا مِن خلالها بروحهم وعواطفهم، وأحيانا يطلقون العنان لعواطفهم وخيالهم ويمزجون بين أحاسيسهم ومظاهر الطبيعة من حولهم، فيبثّون الحياة في الجماد ويتفاعلون معه.
Vitiligo and anti-tissue Transglutaminase of celiac disease in Al- Nasiriyah city, Iraq
Authors: Hasan Rhadi Sabah 
Published: March 2023

Vitiligo is acquired pigmentation disorder characterized by sharply defined white spots of irregular shape and variable dimensions, increasing in volume and number over time. The causes of vitiligo are still unknown. But it involve some theories like autoimmunity, this study was aimed to detection the relationship between the vitiligo and celiac disease by investigating the presence of celiac tissue transglutaminase IgA(tTGA) autoantibody in patients of vitiligo by using ELISA technique . The study was conducted on 100 patients with vitiligo and 100 healthy individual as control , the mean age of vitiligo patient was 19.4 year and control was 26.3 year .The results of study were showed , twenty six of cases have family history of vitiligo , 53 of cases have family history of other autoimmune disorders, as well as 4 of cases have positive family history of vitiligo with diabetes and thyroid disorders. Tissue transglutaminase IgA antibody test was showed ,12 out of 100 of vitiligo cases were registered Seropositivity result to tTGA antibody, while 4 out of 100 of control were Seropositive to this antibody ,other cases and control were negative for IgA antibody.
Nilai Rerata Volume Trombosit, Rasio Trombosit Limfosit, Rasio Rerata Volume Trombosit-Limfosit sebagai Prediktor Tingkat Keparahan Sindrom Koroner Kronik
Authors: Wijaya Friska , Limantoro Charles , Fitria Indah , Suharti Catharina , Nugroho Trilaksana 
Published: March 2023

LATAR BELAKANG : Agregasi trombosit dan inflamasi yang mengalami peningkatan memiliki peran dalam proses aterosklerosis. Besarnya ukuran trombosit menandakan tingkat aktivitasnya. Makin besar ukuran trombosit maka proses trombosis lebih mudah terjadi karena aktivitasnya lebih tinggi. Limfopenia sering dijumpai pada Penyakit Jantung Koroner (PJK) berat. Nilai Rerata Volume Trombosit (RVT), Rasio Trombosit Limfosit (RTL), Rasio Rerata Volume Trombosit-Limfosit (RRVTL) berhubungan dengan keparahan PJK.

TUJUAN : Penelitian ini bertujuan untuk menilai korelasi antara nilai RVT, RTL, dan RRVTL terhadap tingkat keparahan Sindrom Koroner Kronik (SKK) berdasar skor Gensini.

METODE : . Penelitian ini menggunakan metode belah lintang dan dilakukan di RSUP Dr. Kariadi Semarang dengan sampel sebanyak 68 responden. Pasien dikelompokkan berdasar kekompleksan lesi koroner dengan skor Gensini menjadi Gensini ringan (≤20) dan Gensini berat (>20). Nilai RVT, RTL dan RRVTL kemudian dibandingkan pada 2 kelompok tersebut.

HASIL : Terdapat korelasi positif antar nilai RRVTL dengan skor Gensini (r=0,217; p=0,76). Perbedaan signifikan juga didapatkan antara nilai RRVTL pada kelompok Gensini berat dan ringan (p=0,029). Titik potong nilai RRVTL 3,4 memiliki sensitivitas 80%, spesifisitas 50%, Nilai Prediksi Positif (NPP) 82% dan Nilai Prediksi Negatif (NPN) 47% (area bawah kurva 67% (95% IK 52–82); p=0,029). Nilai RRVTL ≥3,4 mempunyai risiko 1,55 kali (95% IK 0,99-2,43; p=0,034) terjadinya lesi koroner kompleks pada pasien dengan SKK. Nilai RTL berkorelasi negatif dengan skor Gensini (r=-0,057; p=0,645). Nilai RVT berkorelasi positif signifikan dengan skor Gensini (r=0,271; p=0,025) namun bukan merupakan prediktor keparahan SKK (OR= 1,26; 95% IK 0,93-1,70; p=0,205).

KESIMPULAN : Nilai RRVTL ≥3,4 dapat digunakan sebagai prediktor tingkat keparahan pada pasien SKK.