bluuebunny/crossref_metadata_2025_split huggingface dataset:
T1-2N1M0 nasopharyngeal carcinoma chemotherapy or not: A retrospective study
Authors: Li Pei-Jing , Chen Ming , Tian Ye 
Published: March 2023

Background
Radiotherapy (RT) combined with chemotherapy is the standard treatment for T1-2N1M0 nasopharyngeal carcinoma (NPC) based on conventional radiotherapy. However, intensity-modulated radiotherapy (IMRT) has narrowed the treatment gap between RT and chemoradiotherapy. Thus, this retrospective study aimed to compare the efficacy of RT and chemoradiotherapy (RT-chemo) in treating T1-2N1M0 NPC in the IMRT era.

Materials and methods
From January 2008 to December 2016, 343 consecutive patients with T1-2N1M0 NPC in two cancer centers were included. All patients received RT or RT-chemo, chemotherapy including induction chemotherapy (IC) + concurrent chemoradiotherapy (CCRT), CCRT, or CCRT + adjuvant chemotherapy (AC). The number of patients who received RT, CCRT, IC + CCRT, and CCRT + AC was 114, 101, 89, and 39. The survival rates were analyzed using the Kaplan-Meier method and compared using the log-rank test. Multivariable analysis was performed to identify valuable prognostic factors.

Results
The median follow-up time for survivors was 93 (range: 55–144) months. The 5-year overall survival (OS), progression-free survival (PFS), locoregional failure-free survival (LRFFS), and distant metastasis-free survival (DMFS) for the RT-chemo and RT groups were 93.7%, 88.5%, 93.8%, 93.8% and 93.0%, 87.7%, 91.9%, 91.2%, respectively (P>0.05 for all outcomes). No significant survival differences were found between the two groups. The T1N1M0 or T2N1M0 subgroup analysis showed that treatment outcomes had no significant differences between the RT and RT-chemo groups. After adjusting for various factors, treatment mode was not identified as an independent prognostic factor for all survival rates.

Conclusions
In this study, outcomes of T1-2N1M0 NPC patients treated by IMRT alone were comparable to chemoradiotherapy, supporting the omission or postponement of chemotherapy.
Determinants of School dropouts among adolescents: Evidence from a longitudinal study in India
Authors: Kumar Pradeep , Patel Sangram Kishor , Debbarma Solomon , Saggurti Niranjan 
Published: March 2023

Introduction
India has the largest adolescent population in the world. However, many unprivileged Indian adolescents are still unable to complete schooling. Hence, there is a need to understand the reasons for school dropout among this population. The present study is an attempt to understand the determinants of school dropout among adolescents and identify the factors and reasons that contribute to it.

Material and methods
Longitudinal survey data- Understanding Adults and Young Adolescents (UDAYA) for Bihar and Uttar Pradesh has been used to identify the determinants of school dropout among adolescents aged 10–19. The first wave of the survey was conducted in 2015–2016, and the follow-up survey in 2018–2019. Descriptive statistics along with bivariate and multivariate analysis was used to observe school dropout rates and factors associated with it among adolescents.

Results
Results show that the school dropout rate was highest among married girls aged 15–19 years (84%), followed by unmarried girls (46%), and boys (38%) of the same age group. The odds of school dropout among adolescents decreased with an increase in household wealth status. School dropout was significantly less likely among adolescents whose mothers were educated as compared to mothers who had no education. Younger boys [AOR: 6.67; CI: 4.83–9.23] and girls [AOR: 2.56; CI: 1.79–3.84] who engaged in paid work were 6.67 times and 2.56 times more likely to drop out of school than those who were not. The likelihood of school dropout was 3.14 times more likely among younger boys [AOR: 3.14; CI: 2.26–4.35], and it was 89% more likely among older boys [AOR: 1.89; CI: 1.55–2.30] who consumed any substances as compared to those who did not consume any substances. Both younger [AOR: 2.05; CI: 1.37–3.05] and older girls [AOR: 1.30; CI: 1.05–1.62] who acknowledged at least one form of discriminatory practice by parents were more likely to drop out of school than their counterparts. Lack of interest in studies/education not necessary (43%) was the predominant reason among younger boys for school dropout, followed by family reasons (23%) and paid work (21%).

Conclusions
Dropout was prevalent among lower social and economic strata. Mother’s education, parental interaction, participation in sports and having role models reduce school dropout. Conversely, factors such as being engaged in paid work, substance abuse among boys, and gender discriminatory practices towards girls, are risk factors for dropout among adolescents. Lack of interest in studies and familial reasons also increase dropout. There is a need to improve the socio-economic status, delay the marital age of girls, and enhance the government incentives for education, give rightful work to girls after schooling, and provide awareness.
Quality of lower limb preoperative skin preparation using colorless versus colored disinfectants–results of an experimental, randomized study in a close to reality setting
Authors: Fink Karsten , Örgel Marcus , Baier Claas , Brauckmann Vesta , Giannoudis Vasilis , Liodakis Emmanouil 
Published: March 2023

Background
Appropriate preoperative skin cleansing is important to control surgical site infections. Both colored and colorless skin disinfectants are available, however certain types of skin preparation, such as octenidine-dihydrochloride with alcohol have a long residual antimicrobial effect but are available only in colorless form. We hypothesized that colorless skin disinfectants lead to more incomplete skin preparation of lower limbs compared to colored agents.

Methods
We randomly assigned healthy volunteers to undergo a determined skin cleansing protocol for total hip arthroplasty in the supine position to either a colored or colorless skin cleansing protocol. The adequacy of skin preparation was compared between orthopedic consultants and residents. The colorless disinfectant was mixed with a fluorescent dye and missed skin areas were visualized using UV lamps. Both preparations were photo-documented following standardized protocols. The primary outcome of interest was the number of legs with an incomplete scrubbed area. The secondary outcome was the cumulative skin area not disinfected.

Results
Fifty-two healthy volunteers (104 legs; 52 colored and 52 colorless) underwent surgical skin preparation. The number of legs incompletely disinfected was significantly higher in colorless compared to colored disinfectant group (38.5% (n = 20) vs. 13.5% (n = 7); p = 0.007). Regardless of the disinfectant, consultants performed better than the residents. When using colored disinfectant, residents incompletely prepared the site in 23.1% (n = 6) compared with 57.7% (n = 15) with a colorless disinfectant (p = 0.023). Conversely consultants using colored disinfectant incompletely prepared the site in 3.8% (n = 1) compared with 19.2% (n = 5) for colorless disinfectant (p = 0.191). The total amount of uncleansed skin was significantly higher using colorless skin disinfectant (mean ± standard deviation: 8.78 cm2± 35.07 vs. 0.65 cm2 ± 2.66, p = 0.002).

Conclusions
Application of colorless skin disinfectants for hip arthroplasty cleansing protocol led to decreased skin coverage among consultants and residents compared to colored preparations. Colored disinfectants remain the gold standard in hip surgery, however we should be aiming to develop newer colored disinfectants with long residual antimicrobial effects to enable visual control during the scrubbing process.
Obstructing Sigmoid Volvulus: An Unusual Complication in a Pediatric Patient With Ulcerative Colitis
Authors: Mittal Aditi , DeRoss Anthony , Goldman Deborah , Chen Charles B. , Kay Marsha 
Published: March 2023

ABSTRACT
Acute colonic dilation in pediatric patients with ulcerative colitis (UC) raises a concern for toxic megacolon, but other rare conditions such as sigmoid volvulus may present in a similar manner. We report a rare case of a teenager with UC without prior surgery who developed an obstructing sigmoid volvulus managed with endoscopic detorsion and decompression. Colonic inflammation in patients with UC may result in a volvulus in the absence of other predisposing factors and should be considered in the differential diagnosis of patients with UC who present with obstructive symptoms with an atypical presentation.
Deux textes archaïques de Kato Symi (Biannos)
Authors: Bile Monique , Brixhe Claude 
Published: March 2023

Abstract
Deux inscriptions archaiques du site cretois de Biannos, pres de l’actuelle Kato Symi, publiees en 1973 (1975) et 2015 dans des revues differentes, revelent deux formes dialectales, dont Claude Brixhe a proposees des hypotheses nouvelles. La premiere forme serait a lire Ϝρό̄το̄, genitif d’un anthroponyme a rattacher au verbe βιβρώσκω, et la seconde doit etre un lapsus calami, a lire Δαταλε<ύ>ς, ethnique cretois.
Solutions to a modified gauged Schrödinger equation with Choquard type nonlinearity
Authors: Xiao Yingying , Qiu Yipeng , Xie Li , Zhu Wenjie 
Published: March 2023

Abstract
In this article, we study the following quasilinear Schrödinger equation:

−
Δ
u
+
V

(

∣
x
∣

)

u
−
κ
u
Δ

(

u

2

)

+
q

h

2

(

∣
x
∣

)

∣
x

∣

2

(

1
+
κ

u

2

)

u
+
q

∫

∣
x
∣

+
∞

h

(

s

)

s

(

2
+
κ

u

2

(

s

)

)

u

2

(

s

)

d

s

u
=

(

I

α

∗
∣
u

∣

p

)

∣
u

∣

p
−
2

u
,

x
∈

R

2

,

-\Delta u+V\left(| x| )u-\kappa u\Delta \left({u}^{2})+q\frac{{h}^{2}\left(| x| )}{| x\hspace{-0.25em}{| }^{2}}\left(1+\kappa {u}^{2})u+q\left(\underset{| x| }{\overset{+\infty }{\int }}\frac{h\left(s)}{s}\left(2+\kappa {u}^{2}\left(s)){u}^{2}\left(s)\hspace{0.1em}\text{d}\hspace{0.1em}s\right)u=\left({I}_{\alpha }\ast | u\hspace{-0.25em}{| }^{p})| u\hspace{-0.25em}{| }^{p-2}u,\hspace{1em}x\in {{\mathbb{R}}}^{2},

where

κ

\kappa

,

q
>
0

q\gt 0

,

p
>
8

p\gt 8

,

I

α

{I}_{\alpha }

is a Riesz potential,

α
∈

(

0
,
2

)

\alpha \in \left(0,2)

and

V
∈
C

(

R

2

,
R

)

V\in {\mathcal{C}}\left({{\mathbb{R}}}^{2},{\mathbb{R}})

. By using Jeanjean’s monotone trick, it can be explored that the aforementioned equation has a ground state solution under appropriate assumptions.
Ultra-high-performance liquid chromatography-tandem mass spectrometry analysis of serum metabolomic characteristics in people with different vitamin D levels
Authors: Li Huan , Xie Xiaomin , Zhang Li , He Yanting , Liu Huili , Qiang Dan , Bai Guirong , Li Ling , Tang Yanpan 
Published: March 2023

Abstract
Vitamin D is a fat-soluble vitamin with multiple functions. However, the metabolism of people with different vitamin D concentrations is still unclear. Herein, we collected clinical data and analysed the serum metabolome of people with 25-hydroxyvitamin D (25[OH]D) ≥40 ng/mL (A), 30 ng/mL ≤25(OH)D <40 ng/mL (B) and 25(OH)D <30 ng/mL (C) by the ultra-high-performance liquid chromatography-tandem mass spectrometry method. We found that haemoglobin A1c, fasting blood glucose, fasting insulin, homeostasis model assessment of insulin resistance and thioredoxin interaction protein were enhanced, while HOMA-β was reduced with the decrease of 25(OH)D concentration. In addition, people in the C group were diagnosed with prediabetes or diabetes. Metabolomics analysis showed that seven, thirty-four and nine differential metabolites were identified in the groups B vs A, C vs A and C vs B, respectively. Metabolites associated with cholesterol metabolism and bile acid biosynthesis, such as 7-ketolithocholic acid, 12-ketolithocholic acid, apocholic acid, N-arachidene glycine and d-mannose 6-phosphate, were significantly upregulated in the C group compared with the A or B groups. In conclusion, the disorder of vitamin D metabolism may be related to cholesterol metabolism and bile acid biosynthesis. This study provided a basis for exploring the possible mechanism leading to abnormal vitamin D metabolism.
Numerical simulation of Burgers’ equations via quartic HB-spline DQM
Authors: Kapoor Mamta 
Published: March 2023

Abstract

Via modified quartic hyperbolic B-spline DQM, Burgers’ equation is numerically approximated in the current study. Ten numerical instances are discussed, and the findings are compared with those already in existence and with exact results. Error norms are assessed, and findings are shown in tabular as well as graphical formats, to validate the resilience and applicability portion of established numerical system. Matrix stability analysis approach is used to discuss proposed scheme’s stability. The current plan is robust, precise, and simple to put into action.
Maschinenlesbares und maschineninterpretierbares digitales Kalibrierzertifikat (DCC) und sein Einsatz in der Praxis
Authors: Hackel Siegfried , Schönhals Shanna , Krah Thomas , Doering Lutz 
Published: March 2023

Zusammenfassung
Der Prototyp eines maschinenlesbaren und maschineninterpretierbaren Digitalen Kalibrierscheins (DCC, engl. Digital Calibration Certificate) wurde bereits im Jahr 2017 in den PTB-Mitteilungen [S. Hackel, F. Härtig, J. Hornig, und T. Wiedenhöfer, The Digital Calibration Certificate, PTB-Mitteilungen, vol. 127, Bd. 4, S. 7, 2017 [Online]. Verfügbar unter: https://oar.ptb.de/resources/show/10.7795/310.20170403 [Zugegriffen: Jul. 2, 2019].] veröffentlicht. Die Idee basiert auf dem im Jahr 2016 von der PTB skizzierten europäischen Forschungsvorhaben SmartCom (17IND02) [,,Welcome to SmartCom”, 2021 [Online]. Verfügbar unter: https://www.ptb.de/empir2018/smartcom/project/ [Zugegriffen: Februar. 15, 2023]; EURAMET-European Association of National Metrology Institutes, ,,Communication and validation of smart data in IoT-networks”, EURAMET, 2023 [Online]. Verfügbar unter: https://www.euramet.org/research-innovation/search-research-projects/details/project/communication-and-validation-of-smart-data-in-iot- networks [Zugegriffen: Februar. 15, 2023.] und ist seit dem Jahr 2017 integraler Bestandteil des Digitalisierungskonzepts der PTB. Der DCC bietet die weltweit eindeutige Identifikation und Speicherung der Eigenschaften eines beliebigen Kalibriergegenstandes und leistet damit mehr als den reinen Nachweis der metrologischen Rückführung. Der von der PTB prototypisch entwickelte DCC beruht auf dem Austauschformat XML und ist damit sowohl zukunftssicher maschinenlesbar als auch maschineninterpretierbar. Darüber hinaus sind alle Anforderungen der DIN ISO 17025 [DIN EN ISO/IEC 17025:2018-03, Allgemeine Anforderungen an die Kompetenz von Prüf- und Kalibrierlaboratorien (ISO/IEC_17025:2017); Deutsche und Englische Fassung EN_ISO/IEC_17025:2017, Beuth Verlag GmbH [Online]. Verfügbar unter: https://www.beuth.de/de/-/-/278030106 [Zugegriffen: Sept. 24, 2021].] berücksichtigt. Für die Darstellung von Messwerten wurde im Projekt SmartCom ein auf den SI-Einheiten basiertes Datenmodell entworfen und ein prototypisches XML-Datenaustauschformat entwickelt. Dieses als D-SI (digitales SI [D. Hutzschenreuter u.a., SmartCom Digital-SI (D-SI) XML Exchange Format for Metrological Data Version 2.0.0, 2021 [Online]. Verfügbar unter: https://zenodo.org/record/4709001 [Zugegriffen: Mär. 10, 2022].]) bezeichnete Format bildet unter anderem die Grundlage für die Angabe von Messdaten im DCC. Darüber hinaus ist es nutzbar für jeglichen anderen Austausch metrologischer Informationen. Alle Angaben einschließlich numerischer Kalibrierkurven können aus dem DCC heraus direkt und automatisiert in digitale Prozesse übernommen werden. Kryptografische Signaturen als Sicherungsverfahren sorgen für die Integrität und Authentizität eines DCC. Alle Konzepte wurden mit Partnern in Europa und der Welt diskutiert, abgestimmt und werden weiterentwickelt.
Metabolic rewiring in keratinocytes by miR‐31‐5p identifies therapeutic intervention for psoriasis
Authors: Wang Mao‐Jie , Huang Huan‐Jie , Xu Yong‐Yue , Vos Harmjan , Gulersonmez Can , Stigter Edwin , Gerritsen Johan , Gallego Marc Pages , van Es Robert , Li Li , Deng Hao , Han Lin , Huang Run‐Yue , Lu Chuan‐Jian , Burgering Boudewijn MT 
Published: March 2023

AbstractBesides genetic alterations, the cellular environment also determines disease onset and progression. When different cell types contribute to disease outcome, this imposes environmental challenges as different cell types likely differ in their extracellular dependencies. Hsa‐microRNA‐31‐5p (miR‐31) is highly expressed in keratinocytes of psoriatic skin, and we show that expression in keratinocytes is induced by limited glucose availability and enables increased survival under limiting glucose conditions by increasing glutamine metabolism. In addition, miR‐31 expression results in not only secretion of specific metabolites (aspartate and glutamate) but also secretion of immunomodulatory factors. We show that this miR‐31‐induced secretory phenotype is sufficient to induce Th17 cell differentiation, a hallmark of psoriasis. Inhibitors of miR31‐induced metabolic rewiring and metabolic crosstalk with immune cells alleviate psoriasis pathology in a mouse model of psoriasis. Together our data illustrate an emerging concept of metabolic interaction across cell compartments that characterizes disease development, which can be employed to design effective treatment options for disease, as shown here for psoriasis.
Improving Physical Fitness Assessment through Movement Tests: Overcoming Implementation Challenges in General Educational Schools
Authors: Vaskov Yurij 
Published: March 2023

Background and Study Aim. The use of objective means and criteria for evaluating the educational achievements of students is crucial to improve the quality of education. Movement tests have been considered as a tool to assess the physical fitness of students in physical education classes. However, there are challenges in implementing these tests effectively. This article aims to address the problem of implementing movement tests in physical education classes in general educational institutions.
Methodology. The study utilized publications from the Vernadskyi National Library and the Google search system. Keywords were used for the search in accordance with the topic of the study. A total of 27 sources were selected for analysis.
Results. The study found that the effective implementation of movement tests in physical education classes requires an in-depth medical examination of students, consideration of each student's reaction level to physical loads, and the use of motor tests solely for evaluation purposes. The study also highlighted that motor tests can help solve complex pedagogical tasks and should meet criteria such as availability, indifference, reliability, capacity, and informativeness.
Conclusions. The study concludes that joint activity between teachers and students is essential for increasing the level of physical fitness. Furthermore, teachers must exercise systematic control of students' health status and their reaction to physical exertion in class. The results of this study can provide insights to educators and policymakers in designing effective physical education programs that include movement tests as an assessment tool.
Postmodern Music Therapy
Authors: Gross Robert 
Published: March 2023

Postmodern music therapy is an approach to music therapy that defines itself in diametric opposition to modernist, or medical-model, music therapy. Where modernist music therapy ignores power dynamics and assumes itself to be value neutral, postmodern music therapy is concerned with power dynamics between client, therapist, and broader society. Postmodern music therapy is based on the theories of Bradley Lewis: Lewis (2006) believes that a postmodern psychiatry (or as he calls it, postpsychiatry) will be more aware of politics and social structures in general and will move toward democratization. This article proposes a postmodern music therapy in parallel to postpsychiatric ideas and ideals. Further, the article explores the intersectional nexus between postmodern music therapy and critical race, disability, queer, and feminist studies.
Why Do Accounting and Business Lecturers Accept Digital Game-Based Learning?
Authors: Kuang Tan Ming , Hanny Hanny , Setiawan Santy 
Published: March 2023

Digital game-based learning has a potential to help accounting and business students acquiring knowledge and skills required for industry 4.0. However, its adoption and effectiveness rely heavily on lecturer acceptance because they are the real agent of change in Higher Education Institution. In this study, a modified TAM model to examine and predict lecturer acceptance of digital game-based learning is proposed, and empirically tested by involving 258 acounting and business lecturers. The results show that lecturers’ intention for adopting digital game-based learning in the classroom is affected directly by several factors: usefulness, subjective norm, and personal innovativeness. Although curriculum effects are not found, its effects appear to be mediated by usefulness. This study does not find direct and indirect impact of critical mass on lectures’ intention for adopting digital game-based learning.
Инфографика как средство визуализации в условиях дистанционного обучения русскому языку как иностранному в вузе
Authors: Забудряева Ю.А. 
Published: March 2023

Рассмотрены возможности применения инфографики на начальном этапе обучения русскому языку как иностранному. На примере инфографики, посвященной теме «Глаголы движения», представлен комплекс упражнений, включающий презентацию и проработку нового лексико-грамматического материала. Описаны типы заданий, их функции и структура, что позволяет представить работу с инфографикой с точки зрения различных аспектов обучения русскому языку как иностранному.
The opportunities of use infographics on initial stage of learning Russian as a foreign language are considered in the article. On the example of infographics devoted to the verb of moving the complex of exercises was off ered. The exercises include presentation and practice of new vocabulary and grammar. The types of exercises, their functions and structure allow to use infographics in diff erent language aspects are described.
Психолого-педагогическая готовность будущих педагогов и социальных работников к самопомощи при эмоциональном выгорании как фактор профессиональной компетенции
Authors: Юдина Е.И. , Люткене Г.В. 
Published: March 2023

Статья посвящена проблеме профилактики эмоционального выгорания у будущих представителей социономических профессий и такому фактору их профессиональной компетенции, как сформированность психолого-педагогической готовности к осуществлению самопомощи. Овладение навыками самопомощи рассмотрено на примере двух групп студентов: будущих педагогов и будущих специалистов по социальной работе. Авторами охарактеризованы различные модели овладения навыками самопомощи в связи со спецификой будущей профессиональной деятельности, раскрыты принципы, функции, формы данной работы.
The article is devoted to the problem of prevention of emotional burnout in future representatives of socionomic professions, which is expressed in the presence of such a factor of professional competence as the formation of psychological and pedagogical readiness for self-help. Mastering self-help skills is considered on the example of 2 groups: students – future teachers and future specialists in social work. The authors characterize various models of mastering self-help skills in connection with the specifi cs of future professional activity, disclosed the principles, functions, forms of this work.