bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building good knowledge or blaming bad parents? Examining the construction of parents and parenting in a corpus of parent focussed cochlear implant research articles
Authors: Kecman Emily 
Published: February 2023

AbstractParents of deaf children with a cochlear implant (CI) report feeling pressure to adhere to a very prescribed conceptualisation of ‘good parenting’, and in some cases report feeling judged or blamed, for example, if the child's progress post‐CI is slower than expected. Previous investigations of the discourses of parenting science suggest that, while parent blame is rarely expressed explicitly, that normative, moral assumptions about how ‘good parents of a disabled child’ should feel, think and act are embedded within prevalent concepts and terminology. A disproportionate focus on evaluating individual parents' personal characteristics at the expense of more external, socially located issues has also been noted. Existing critiques, together with the author's lived experience provide the impetus for this study; in which corpus linguistics methods have been used to document the types of parents and parenting attributes constructed in a 420,982 corpus of research articles. The results indicate the prevalence of many highly evaluative parenting noun‐collocates within the field; successful adaptation, a positive appraisal of the situation, realistic expectations, rational decisions, high involvement and full‐time use of the CI are conflated with good parenting, whilst parents who present in alternate ways are construed as problematic. Implications for future research are discussed.
Establishment of aBRAF V595E‐mutant canine prostate cancer cell line and the antitumor effects ofMEKinhibitors against canine prostate cancer
Authors: Kobayashi Masanori , Onozawa Moe , Watanabe Shiho , Nagashima Tomokazu , Tamura Kyoichi , Kubo Yoshiaki , Ikeda Akiko , Ochiai Kazuhiko , Michishita Masaki , Bonkobara Makoto , Kobayashi Masato , Hori Tatsuya , Kawakami Eiichi 
Published: February 2023

AbstractCanine prostate cancer (cPCa) is a malignant neoplasm with no effective therapy. The BRAF V595E mutation, corresponding to the human BRAF V600E mutation, is found frequently in cPCa. Activating BRAF mutations are recognized as oncogenic drivers, and blockade of MAPK/ERK phosphorylation may be an effective therapeutic target against BRAF‐mutated tumours. The aim of this study was to establish a novel cPCa cell line and to clarify the antitumor effects of MEK inhibitors on cPCa in vitro and in vivo. We established the novel CHP‐2 cPCa cell line that was derived from the prostatic tissue of a cPCa patient. Sequencing of the canine BRAF gene in two cPCa cell lines revealed the presence of the BRAF V595E mutation. MEK inhibitors (trametinib, cobimetinib and mirdametinib) strongly suppressed cell proliferation in vitro, and trametinib showed the highest efficacy against cPCa cells with minimal cytotoxicity to non‐cancer COPK cells. Furthermore, we orally administered 0.3 or 1.0 mg/kg trametinib to CHP‐2 xenografted mice and examined its antitumor effects in vivo. Trametinib reduced tumour volume, decreased phosphorylated ERK levels, and lowered Ki‐67 expression in xenografts in a dose‐dependent manner. Although no clear adverse events were observed with administration, trametinib‐treated xenografts showed osteogenesis that was independent of dosage. Our results indicate that trametinib induces cell cycle arrest by inhibiting ERK activation, resulting in cPCa tumour regression in a dose‐dependent manner. MEK inhibitors, in addition to BRAF inhibitors, may be a targeted agent option for cPCa with the BRAF V595E mutation.
A Study of Service Touchpoints in the Design of Assistive Products Required by People with Visual Impairment
Authors: Hei Yirui , Dolah Jasni , Hei Shenghai 
Published: February 2023

This review investigates the problem of hospital orientation touchpoints for individuals with visual impairments. This paper aims to provide a framework for the service design considerations that designers and engineers of medical devices must consider to aid the visually impaired people in the hospital orientation. In addition, service design and design thinking techniques were utilized to synthesize the findings. Four-person focus groups were used to conduct semi-structured interviews. Using purposeful sampling, a group of Yinchuan, China, visually impaired people were chosen to be interviewed and guided through a series of fictitious medical crises. Using a user journey map and service touchpoint analysis, the service touchpoints encountered by the visually impaired population while using the guided care service were summarized and unified, yielding into several design recommendations. Based on the research provided in the research on assistive device design for the visually impaired population and the collected studies on hospital guidance services, current research on hospital guidance services is focused more on changing service design from the hospital perspective. The potential scenario applications of this wearable device have been largely neglected in previous studies on the design of assistive devices for people with visual impairment. Finally, the contact points that visually impaired people will encounter in the hospital alone were divided into three: before, during, and after the visit. These contacts were divided into eight categories. Although research on inclusive design and related topics from the perspective of the visually impaired has increased, very little has been done to examine this issue from the perspective of actual use cases. Despite the importance of the design and technology phases of product development, there is still a need for further research into the design of antecedent services in the context of what people with visual impairment require.
Convolutional Neural Network Based Defect Recognition Model for Phased Array Ultrasonic Testing Images of Electrofusion Joints
Authors: Tao Yangji , Shi Jianfeng , Guo Weican , Zheng Jinyang 
Published: February 2023

AbstractThis technical brief proposes a defect recognition model to recognize four typical defects of phased array ultrasonic testing (PA-UT) images for electrofusion (EF) joints. PA-UT has been proved to be the most feasible way to inspect defects in EF joints of polyethylene pipes. The recognition of defects in PA-UT images relies on the experience of operators, resulting in inconsistent defective detection rate and low recognition speed. The proposed recognition model was composed of an anomaly detection model and a defect detection model. The anomaly detection model recognized anomalies in PA-UT images, meeting the requirement of real-time recognition for practical inspection. The defect detection model classified and located defects in abnormal PA-UT images, achieving high accuracy of defects recognition. By comparing detection models, optimizing parameters and augmenting dataset, the anomaly detection model and defect detection model reached a good combination of accuracy and speed.
Assessing Toughness Levels for Nuclear Containment Vessels Steel to Determine the Need for Postweld Heat Treatment Based on the Master Curve Method
Authors: Chen Zehong , Zhang Yalin , Huang Song , Hui Hu 
Published: February 2023

AbstractIn this paper, a minimum toughness assessment method of exempting postweld heat treatment (PWHT) based on the master curve method is proposed to replace the current method of determining whether to perform PWHT by material thickness. Reference temperature to prevent fracture (T0-required) for structure to be exempt from PWHT at minimum design metal temperature (MDMT) was obtained by using the master curve method under presumed stresses and flaw size. A series of exemption curves were generated for the steels used in pressure vessels with yield strength of 300∼550 MPa, and the method was corrected for low-stress conditions. Then the feasibility of this method was verified by an engineering example. A SA-738Gr.B welded joint in the example was taken as the research object, the experiment showed that the weld metal was the worst part of the fracture toughness of the joint. The results of research objects which were exempted from PWHT by the proposed method are consistent with ASME Code Case N-841, which proves that this method is feasible in assessing the exemption from PWHT.
Estimation of Subsea Line Structure Behavior Based on Sequential Data Assimilation with Distributed Sensing
Authors: Kojima Shun , Wada Ryota , Murayama Hideaki 
Published: February 2023

Abstract
In this paper, a method that estimates the real-time behavior of subsea line structures based on sequential data assimilation with distributed strain sensors is proposed. A finite element method is used to represent the behavior of subsea line structures and generates ensemble forecasts regarding unknown parameters. A merging particle filter technique is applied to integrate the observation data with the numerical models to calculate the posterior probability density function. The effectiveness of the proposed method is examined through twin experiments. The presented results validate the proposed method's capability to estimate the current state as well as unknown parameters of subsea line structures. The results suggest the advantage of distributed sensors against pointwise sensing when applied to line structures.
Validation of a deep learning system for the detection of diabetic retinopathy in Indigenous Australians
Authors: Chia Mark A , Hersch Fred , Sayres Rory , Bavishi Pinal , Tiwari Richa , Keane Pearse A , Turner Angus W 
Published: February 2023

Background/aimsDeep learning systems (DLSs) for diabetic retinopathy (DR) detection show promising results but can underperform in racial and ethnic minority groups, therefore external validation within these populations is critical for health equity. This study evaluates the performance of a DLS for DR detection among Indigenous Australians, an understudied ethnic group who suffer disproportionately from DR-related blindness.MethodsWe performed a retrospective external validation study comparing the performance of a DLS against a retinal specialist for the detection of more-than-mild DR (mtmDR), vision-threatening DR (vtDR) and all-cause referable DR. The validation set consisted of 1682 consecutive, single-field, macula-centred retinal photographs from 864 patients with diabetes (mean age 54.9 years, 52.4% women) at an Indigenous primary care service in Perth, Australia. Three-person adjudication by a panel of specialists served as the reference standard.ResultsFor mtmDR detection, sensitivity of the DLS was superior to the retina specialist (98.0% (95% CI, 96.5 to 99.4) vs 87.1% (95% CI, 83.6 to 90.6), McNemar’s test p<0.001) with a small reduction in specificity (95.1% (95% CI, 93.6 to 96.4) vs 97.0% (95% CI, 95.9 to 98.0), p=0.006). For vtDR, the DLS’s sensitivity was again superior to the human grader (96.2% (95% CI, 93.4 to 98.6) vs 84.4% (95% CI, 79.7 to 89.2), p<0.001) with a slight drop in specificity (95.8% (95% CI, 94.6 to 96.9) vs 97.8% (95% CI, 96.9 to 98.6), p=0.002). For all-cause referable DR, there was a substantial increase in sensitivity (93.7% (95% CI, 91.8 to 95.5) vs 74.4% (95% CI, 71.1 to 77.5), p<0.001) and a smaller reduction in specificity (91.7% (95% CI, 90.0 to 93.3) vs 96.3% (95% CI, 95.2 to 97.4), p<0.001).ConclusionThe DLS showed improved sensitivity and similar specificity compared with a retina specialist for DR detection. This demonstrates its potential to support DR screening among Indigenous Australians, an underserved population with a high burden of diabetic eye disease.
Impact of breastfeeding on the incidence and severity of respiratory syncytial virus (RSV)-associated acute lower respiratory infections in infants: a systematic review highlighting the global relevance of primary prevention
Authors: Mineva Gabriela M , Purtill Helen , Dunne Colum P , Philip Roy K 
Published: February 2023

BackgroundRespiratory syncytial virus (RSV) is the principal cause of acute lower respiratory infections (ALRI) among infants worldwide, and an important cause of morbidity, hospitalisation and mortality. While infants are universally exposed to RSV, most mortality occurs among normal term infants from low-income and middle-income countries. Breastfeeding has been suggested to have a protective effect against RSV infection. This study aims to determine the association of breastfeeding on the frequency and severity of RSV-associated ALRI among infants.MethodsA systematic review was conducted using keywords and Medical Subject Headings on MEDLINE, PubMed, Google Scholar, EMBASE, MedRxiv and Cochrane Central Register of Controlled Trials. Full-text articles published in English from 2000 to 2021 that studied exclusively or partially breastfed infants who developed RSV-associated ALRI <12 months of age were included. Covidence software-based evidence extraction and Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol guidelines were followed. Quality of evidence was analysed using UK National Service Framework grading and the risk-of-bias assessment using Robvis.ResultsAmong 1368 studies screened, 217 qualified full-text review and 198 were excluded based on pre-agreed criteria. Nineteen articles published from 12 countries that included 16 787 infants from 31 countries (of which 8 middle-income) were retained for analysis. Results indicate that non-breastfeeding practices pose a significant risk for severe RSV-associated ALRI and hospitalisation. Exclusive breastfeeding for >4–6 months significantly lowered hospitalisation, length of stay, supplemental oxygen demand and admission to intensive care units.ConclusionIn the context of no effective or standardised treatment for established RSV-associated ALRI, available evidence suggest that breastfeeding is associated with lower frequency and severity of RSV-associated ALRI, based on observational studies of variable grades of evidence and risk-of-bias. With both exclusive and partial breastfeeding benefiting infants who develop RSV-associated ALRI, breastfeeding should be promoted globally as an adjunct primary prevention; in addition to emerging immunoprophylaxis and maternal immunisation strategies.
Roles and effectiveness of knowledge brokers for translating clinical practice guidelines in health-related settings: a systematic review
Authors: Cross Amanda J , Haines Terry P , Ooi Choon Ean , La Caze Adam , Karavesovska Sara , Lee Eu Jin , Siu Samuel , Sareen Sagar , Jones Carlos , Steeper Michelle , Bell John Simon 
Published: February 2023

BackgroundPoor translation of clinical practice guidelines (CPGs) into clinical practice is a barrier to the provision of consistent and high-quality evidence-based care. The objective was to systematically review the roles and effectiveness of knowledge brokers (KBs) for translating CPGs in health-related settings.MethodsMEDLINE, Embase, PsycINFO and CINAHL Plus were searched from 2014 to June 2022. Randomised controlled trials (RCTs), controlled and uncontrolled preintervention and postintervention studies involving KBs, either alone or as part of a multicomponent intervention, that reported quantitative postintervention changes in guideline implementation in a healthcare setting were included. A KB was defined as an intermediary who facilitated knowledge translation by acting in at least two of the following core roles: knowledge manager, linkage agent or capacity builder. Specific activities undertaken by KBs were deductively coded to the three core roles, then common activities were inductively grouped. Screening, data extraction, quality assessment and coding were performed independently by two authors.Results16 studies comprising 6 RCTs, 8 uncontrolled precomparisons–postcomparisons, 1 controlled precomparison–postcomparison and 1 interrupted time series were included. 14 studies (88%) were conducted in hospital settings. Knowledge manager roles included creating and distributing guideline material. Linkage agent roles involved engaging with internal and external stakeholders. Capacity builder roles involved audit and feedback and educating staff. KBs improved guideline adherence in 10 studies (63%), had mixed impact in 2 studies (13%) and no impact in 4 studies (25%). Half of the RCTs showed KBs had no impact on guideline adherence. KBs acted as knowledge managers in 15 (94%) studies, linkage agents in 11 (69%) studies and capacity builders in all studies.ConclusionKnowledge manager and capacity builder roles were more frequently studied than linkage agent roles. KBs had mixed impact on translating CPGs into practice. Further RCTs, including those in non-hospital settings, are required.PROSPERO registration numberCRD42022340365.
Longitudinal associations of household use of cleaning agents and asthma symptoms in women: the EGEA study
Authors: Pacheco Da Silva Emilie , Ngutuka Mélanie , Dumas Orianne , Orsi Laurent , Ait-hadad Wassila , Lemire Pierre , Quentin Joane , Pin Isabelle , Varraso Raphäelle , Siroux Valérie , Le Moual Nicole 
Published: February 2023

ObjectiveTo evaluate the associations between the evolution of household use of cleaning products with the asthma symptom score and its evolution over 8 years.MethodsOur study is based on 509 women participating in the last two surveys of the Epidemiological study on the Genetics and Environment of Asthma (EGEA) study (EGEA2: 2003–2007 (44 years, 19% current smokers) and EGEA3: 2011–2013). We assessed an asthma symptom score and the use of household cleaning products through standardised questionnaires. We studied longitudinal associations of the evolution of weekly use of irritant or spayed cleaning products with (1) the asthma symptom score at EGEA3 and a stable symptom score between EGEA2-EGEA3 (negative binomial models) and (2) the incidence/evolution of asthma symptoms between EGEA2-EGEA3 (logistic/polytomous logistic regressions). Models accounted for familial dependence and were adjusted for age, smoking status, body mass index and occupational exposure to asthmagens.ResultsPersistent and increased (40% and 16%, respectively) weekly use of irritants or sprays were associated with a higher risk of asthma symptoms at EGEA3 (Mean Score Ratio (MSR)=1.51 (95% CI 1.06 to 2.14) and 1.33 (95% CI 0.85 to 2.08), respectively). A decreased use (19%) was associated with a lower risk of symptoms at EGEA3, compared with a persistent use (MSR=0.59 (95% CI 0.39 to 0.88)). We also observed an association between an increased use of sprays and the incidence of asthma symptoms (OR=2.30 (95% CI 1.08 to 4.91)), compared with no weekly use of irritants/sprays.ConclusionsThis longitudinal study, with repeated assessment of exposure and respiratory health, supports the hypothesis that a persistent or increased weekly use of sprayed cleaning products over time may have an adverse effect on the evolution of asthma symptoms.
Light quark decays of doubly heavy baryons in light front approach
Authors: Liu Hang , Xing Zhi-Peng , Yang Chang 
Published: February 2023

AbstractWe explore the semileptonic and nonleptonic decays of doubly heavy baryons $$(\Omega _{cc}^{(*)+},\Omega _{bb}^{(*)0},\Omega _{bc}^{(*)-},\Omega _{bc}^{\prime 0})$$

(

Ω

cc

(

∗
)
+

,

Ω

bb

(

∗
)
0

,

Ω

bc

(

∗
)
-

,

Ω

bc

′
0

)

induced by the $$s\rightarrow u$$

s
→
u

transition. Hadronic form factors are parametrized by transition matrix elements and are calculated in the light front quark model. With the form factors, we make use of helicity amplitudes and analyze semileptonic and nonleptonic decay modes of doubly heavy baryons. Benchmark results for partial decay widths, branching fractions, forward–backward asymmetries and other phenomenological observables are derived. We find that typical branching fractions for semileptonic decays into $$\ell \bar{\nu }$$

ℓ

ν

¯

are at the order $$10^{-7}-10^{-8}$$

10

-
7

-

10

-
8

and the ones for nonleptonic decays are at the order $$10^{-5}$$

10

-
5

, which are likely detectable such as in LHCb experiment. With the potential data accumulated in future, our results may help to shape our understanding of the decay mechanism in the presence of two heavy quarks.
Effects of Tributyrin Supplementation on Growth Performance, Intestinal Digestive Enzyme Activity, Antioxidant Capacity, and Inflammation-Related Gene Expression of Large Yellow Croaker (Larimichthys crocea) Fed with a High Level of Clostridium autoethanogenum Protein
Authors: Wang Xiuneng , Wan Min , Wang Zhen , Zhang Haitao , Zhu Si , Cao Xiufei , Xu Ning , Zheng Jichang , Bu Xianyong , Xu Wei , Mai Kangsen , Ai Qinghui 
Published: February 2023

An 8-week growth experiment was conducted to investigate effects of tributyrin (TB) supplementation on growth performance, intestinal digestive enzyme activity, antioxidant capacity, and inflammation-related gene expression of juvenile large yellow croaker (Larimichthys crocea) (initial weight of

12.90
±
0.02

g

) fed diets with high level of Clostridium autoethanogenum protein (CAP). In the negative control diet, 40% fish meal was used as the major source of protein (named as FM), while 45% fish meal protein of FM was substituted with CAP (named as FC) to form a positive control diet. Based on the FC diet, grade levels of 0.05%, 0.1%, 0.2%, 0.4%, and 0.8% tributyrin were added to formulate other five experimental diets. Results showed that fish fed diets with high levels of CAP significantly decreased the weight gain rate (WGR) and specific growth rate (SGR) compared with fish fed the FM diet (

P
<
0.05

). WGR and SGR were significantly higher than in fish fed diets with 0.05% and 0.1% tributyrin that fed the FC diet (

P
<
0.05

). Supplementation of 0.1% tributyrin significantly elevated fish intestinal lipase and protease activities compared to FM and FC diets (

P
<
0.05

). Meanwhile, compared to fish fed the FC diet, fish fed diets with 0.05% and 0.1% tributyrin showed remarkably higher intestinal total antioxidant capacity (T-AOC). Malondialdehyde (MDA) content in the intestine of fish fed diets with 0.05%-0.4% tributyrin was remarkably lower than those in the fish fed the FC diet (

P
<
0.05

). The mRNA expressions of tumor necrosis factor α (tnfα), interleukin-1β (il-1β), interleukin-6 (il-6), and interferon γ (ifnγ) were significantly downregulated in fish fed diets with 0.05%-0.2% tributyrin, and the mRNA expression of il-10 was significantly upregulated in fish fed the 0.2% tributyrin diet (

P
<
0.05

). In regard to antioxidant genes, as the supplementation of tributyrin increased from 0.05% to 0.8%, the mRNA expression of nuclear factor erythroid 2-related factor 2 (nrf2) demonstrated a trend of first rising and then decreasing. However, the mRNA expression of Kelch-like ECH-associated protein 1 (keap1) was remarkably lower in fish fed the FC diet than that fed diets with tributyrin supplementation (

P
<
0.05

). Overall, fish fed tributyrin supplementation diets can ameliorate the negative effects induced by high proportion of CAP in diets, with an appropriate supplementation of 0.1%.
Recepção poética de Basílio da Gama
Authors: Autores Vários 
Published: February 2023

Poemas de Joaquim Inácio De Seixas Brandão, Claúdio Manuel Da Costa, Inácio José De Alvarenga Peixoto, Pedro Antônio Correia Garção, Filinto Elísio, Manuel Inácio Da Silva Alvarenga, João Xavier De Matos, Padre Manuel De Macedo Pereira De Vasconcelos, E. G. P., Antônio Dinis Da Cruz E Silva, Machado De Assis, Padre José Joaquim Correia De Almeida, Raul Pederneiras, Hermes Fontes e Gilberto Mendonça Teles.