bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Antenatal Lifestyle Interventions in Pregnant Women with Normal Body Mass Index
Authors: Yang Hong , Zhao Yun , Tu Jiahui , Chang Yanan , Xiao Chanyun 
Published: February 2023

Background: We aimed to explore the effect of lifestyle interventions on improving lifestyle behaviors on gestational weight gain in pregnant women with normal body mass index (BMI).
Methods: The study was conducted in Maternal and Child Health Hospital of Hubei Province (Wuhan, China) between June 2020 and April 2022. A total of 355 pregnant women (<12 weeks of pregnancy) were enrolled and finally completed the program. Participants were divided into the intervention and control groups. The intervention group received an individualized lifestyle intervention focusing on healthy lifestyle, like diet, exercise, and weight monitoring as four sessions at 16–18, 20–24, 28-30 and 34 weeks’ gestation. Participants in the control group received routine antenatal care. The weight of both group was recorded from pregnancy until 6-8 weeks postpartum.
Results: The participants in the intervention group with normal pre-pregnancy BMI (n = 178) had lower GWG, excessive GWG, hypertension, and neonate birth weight compared to the control group (n = 177, P< 0.01). There were no statistically significant differences in the occurrence of gestational diabetes, premature labor, delivery mode, preterm birth, small for gestational age, macrosomia, number of neonates referred to the NICU, and postpartum weight retention.
Conclusion: Even though lifestyle intervention in pregnant women with normal BMI has a relatively limited effect, attention should still be paid to reasonable weight gain during pregnancy and the potential long-term impact of the intervention remains to be assessed.
Impact of working capital management on profitability of Industrial sector in Iraq
Authors: Ibrahim Sardar Shaket 
Published: February 2023

This paper observes the impact of working capital management on profitability of industrial sector in Iraq. Four companies based in Iraq namely: Iraqi Date processing, Iraqi carton manufactories, Baghdad soft drinks and Iraqi for tufted carpets randomly selected and analyzed for the present study over the period 2007 to 2016. Annual reports of these companies have been studied and significant ratios calculated. The variables that were identified as independent for working capital were, current ratio and quick ratio, while return on equity ROE as dependent variable for profitability. The Ordinary Least Square (OLS) model used to examine the impact of working capital management on profitability. Results indicate that ROE is positively related with working capital variables.
Efficacy and safety of Tong-luo Qu-tong plaster for cervical spondylotic radiculopathy: study protocol for a randomized, double-blind, parallel positive controlled, multicenter clinical trial
Authors: Li Hui , Xie Xingwen , Zhao Yongli , Wang Minzhen , Li Jianguo , Li Dingpeng , Li Ning 
Published: February 2023

Abstract
Background: Cervical spondylotic radiculopathy (CSR) is one of the most common diseases in clinic. Clinical symptoms such as neck pain and upper limb numbness are mainly caused by cervical degenerative changes and compression of cervical nerve roots. The incidence of CSR is the highest among all types of cervical spondylosis, accounting for about 60%~70%, seriously affecting the quality of life and work, causing huge economic negative to patients. Traditional Chinese medicine (TCM) has been definited efficacy and unique advantages in the treatment of CSR. Tongluo Qutong plaster (TLQT) is the most commonly used external drug in China in the treatment of CSR. It is effective for patients to improve neck pain, stiffness and numbness of both upper limbs, but there is a lack of high-quality clinical evidence to support it. The purpose of this study was to evaluate the efficacy and safety of TLQT in the treatment of CSR.
Methods: This is a randomized, double-blind, parallel positive controlled, multi-center clinical trial. 240 patients who met the inclusion criteria were randomly divided into TLQT group and diclofenac sodium plaster group. The treatment period was 3 weeks. Follow-up will be conducted 12 weeks after intervention completion. The main observation index was visual analogue scale (VAS), and the secondary observation index was neck disability index (NDI) and TCM syndrome score. Safety observation indicators will include electrocardiogram, blood tests (including blood routine tests, liver and renal function), routine urine tests, and routine stool tests.The primary and secondary indicators will be performed at 0th, 3th, 7th, 21th and 84th day, and the safety indicators will be performed at 0th, 21th day.
Conclusion: This study will provide evidence for the efficacy and safety of TLQT in treating CSR patients.
Trial registration:This protocol has been registered in Chinese Clinical Trials Registry. Registration number: ChiCTR2200062271. Registered on 31 July 2022.
Plasma D-dimer concentrations as a risk factor in patients with acute heart failure
Authors: Song Li , Feng Yanli , Li Peiwu , Qin Jing , Ma Xiaofeng 
Published: February 2023

Abstract
Objective: The clinical study aims to evaluate the risk factors associated with Acute Heart Failure (AHF) patients, classified according to clinical symptoms and signs.
Methods and findings: 181 AHF patients took part in this cross-sectional clinical investigation. Additionally, there are four categories of AHF patients (warm and wet, warm and dry, cold and wet, and cold and dry) and this not only guides the treatment therapy but also enables the progression of AHF in patients to be assessed.
Results: Based on the results of the standard logistic regression, it can be concluded that individuals with acute heart failure with elevated d-dimer levels were substantially more likely to be "cool and dry" (odds ratio [OR] 1.12, 95% confidence intervals [CI] (0.017;0.212); P=0.022). Additionally, a strong association was identified between the "cold and dry" and the lower patient age (OR 0.95, 95% CI (-0.084;0.011); P=0.011). However, it is important to note that the age differences between the four groups have little clinical significance.
Conclusions: It can be deduced that there is a significant relationship between the essential circumstances of symptoms and signs in patients with AHF and higher d-dimer levels.
Non-clinical Study of Biodistribution of Human Immature Dental Pulp Stem Cells (Nestacell® Product) Following Intravenous Administration in Mice
Authors: Valverde Cristiane Wenceslau , Gamarra Lionel Fernel , Gonzaga Vivian Fonseca , Gárate Ana Paula , Policiquio Bruna de Oliveira , Cintra Luciana , Falcone Cleide , Ynoue Leandro Hideki , Ferrara Luciana , Araldi Rodrigo Pinheiro , Pagani Eduardo , Kerkis Irina 
Published: February 2023

Abstract
Background: Although the safety of mesenchymal stroma/stem cells (MSCs)-based therapies had already extensively demonstrated, non-clinical biodistribution studies are essential for predicting the safety and efficacy of these cells. Herein we assessed the biodistribution of human immature dental pulp stem cells (hIDPSCs), which has investigated as a candidate for the treatment of Huntington’s disease (HD).
Method: For this, we intravenously transplanted hIDPSCs transfected with luciferase or labeled with magnetic nanoparticle in C57BL/6 mice and performed the bioluminescence image (BLI) or inductively coupled plasma mass spectrometer (ICP-MS) to quantity in vivo and ex vivo biodistribution after 4h, 24h, 3, 7, and 30 days of the hIDPSCs administration.
Results: BLI’s results showed the presence of hIDPSCs in the chest, lungs, and head after 4h, 24 h, and 3 days of the cell transplantation. No bioluminescent signal was observed in the chest or head on days 7 and 30 days. The ICP-MS’s results showed that the hIDPSCs engraft into the liver, kidney, heart, and lungs. However, the number of hIDPSCs in these sites significantly reduced from the seventh day, being undetectable on the 30th day. By contrast, we observed that the hIDPSCs not only engrafted into the brain, but also remain in this organ for 30 days.
Conclusion: These data provide evidence that the hIDPSCs successfully engraft and remain in the brain for until 30 days after the cell transplantation, demonstrating that these cells can migrate and homing to the brain, being a useful candidate for the treatment of neurodegenerative disorders, such as HD.
TRIM27 promotes non-small cell lung cancer progression by enhancing P53 degradation
Authors: Hou Guoxin 
Published: February 2023

Abstract
Background: The biological impact and mechanisms of action of tripartite motif 27 (TRIM27) in non-small cell lung cancer (NSCLC) are unclear.
Methods and results: Pan-cancer bioinformatic analysis revealed that TRIM27 expression was elevated in the lung adenocarcinoma and lung squamous cell carcinoma subtypes of NSCLC, and was correlated with unfavorable prognosis in NSCLC patients. Upregulation of TRIM27 mRNA expression in patients may be due to its promoter demethylation and genetic copy number amplification. Further, loss-of-function analysis demonstrated that TRIM27 depletion mitigated NSCLC cell viability, cell cycle progression, migration, invasion, and stemness. Mechanistically, TRIM27 interacted with P53, resulting in the augmentation of P53 ubiquitination levels and degradation. Notably, P53 knockdown significantly alleviated the inhibitory effect of TRIM27 depletion on NSCLC cell malignancy, indicating that P53 is a vital target of TRIM27.
Conclusion: TRIM27 enhances NSCLC progression by targeting P53 for ubiquitination and degradation.
miR-188-5p silencing improves cerebral ischemia/reperfusion injury by targeting Lin28a
Authors: Pei Chaoying , Hou Dan , Yu Dan , Yang Guoshuai 
Published: February 2023

Abstract
This report aimed to explore whether miR-188-5p regulated the pathological regulatory network of cerebral ischemia/reperfusion (I/R) injury. We simulated the cerebral I/R injury model with MACO/R and OGD/R treatments. Neuronal viability and apoptosis were assessed. The contents of miR-188-5p and Lin 28a were evaluated. The abundances of apoptosis-related proteins (Bax, Bcl-2 and cleaved caspase-3) and pro-inflammatory cytokines (TNF-α, 1L-1β, and IL-6) were measured. The interaction of miR-188-5p and Lin28a was confirmed. Lin28a silencing was supplemented to determine the delicate regulation of miR-188-5p. We revealed that miR-188-5p was upregulated and Lin28a was downregulated in I/R rats and OGD/R-induced cells. miR-188-5p silencing remarkably reduced the cerebral infarction volume, neurobehavioral score, brain edema, and Evans blue leakage. miR-188-5p silencing enhanced neuronal viability and alleviated apoptosis. The abundance of Bax and cleaved caspase-3 was reduced by miR-188-5p silencing, while Bcl-2 was augmented. miR-188-5p silencing impeded the contents of TNF-α, 1L-1β, and IL-6. miR-188-5p interacted with Lin28a and negatively regulated its expression. Interestingly, extra Lin28a silencing reversed apoptosis and the content of inflammatory cytokines. Our studies confirmed that miR-188-5p silencing alleviated neuronal apoptosis and inflammation by mediating the expression of Lin28a. The crosstalk of miR-188-5p and Lin28a offered a different direction for ischemic stroke therapy.
Prediction of Rainfall Induced Landslide Using Machine Learning Models along Highway Bandipora to Gurez Road, J&amp;K, India
Authors: Nanda Aadil Manzoor , Lone Fayaz Ahmad , Ahmed Pervez 
Published: February 2023

Abstract
The present study attempts to explore the efficacy of machine learning models in landslide predictions caused by rainfall events along Highway from Bandipora to Gurez, J&K, India. Random Forest (RF) and Logistic Regression (LR) Models were employed to find the optimal parameters for targeted feature i.e. landslide prediction. These models were evaluated for accuracy using the receiver operating characteristics, area under the curve (ROC-AUC) and false negative rate (FNR). The results reveal a positive correlation between antecedent precipitation and landslide occurrence rather than between single-day landslide and rainfall events. Comparing the two models, LR model’s performance is well within the acceptable limits of FNR and therefore could be preferred for landslide prediction over RF. LR model’s incorrect prediction rate is 8.48% without including antecedent precipitation data and 5.84% including antecedent precipitation data. Our study calls for wider use of Machinery Learning Models for developing early warning systems of landslides.
Efficacy of cell therapy for osteonecrosis of the hip compared with hip arthroplasty in sickle cell disease: a systematic review
Authors: Botelho Valéria , Gomes Stéfany de Lima , Pereira Beatriz Neves da Rocha , de Souza Andreza Maria Luzia Baldo , Souza Lohana Guimarães , Tamay Tamay Botelho , Santos Roberto Dias , Pereira Antonio Carlos 
Published: February 2023

Abstract

Objective: To evaluate the clinical efficacy and effectiveness of the use of cell therapy in the treatment of osteonecrosis of the hip in people with sickle cell disease (SCD) compared with hip arthroplasty.
Methodology: Articles published from 2015 to 2019 in English, Portuguese, or Spanish were screened in the following databases: Cochrane, PubMed, Science Research, CAPES (Coordination for the Improvement of Higher Education Personnel), Virtual Health Library (VHL) and SciELO (Scientific Electronic Library Online). The following keywords were used: cell therapy, osteonecrosis, hip, sickle cell anemia and arthroplasty. People with sickle cell disease who developed osteonecrosis of the hip and underwent treatment using cell therapy or hip arthroplasty were selected as the sample.
Results: After refining the searches and organizing the references, seven studies were selected that met the eligibility criteria.
Discussion: We found that out of the seven studies evaluated, three presented autologous bone marrow cell implantation and four presented hip arthroplasty (THA) as an intervention procedure in osteonecrosis of the hip in people with SCD. In all studies in which THA was used, there was a higher prevalence of complications such as vaso-occlusive crises, pain, surgical wound infection and reintervention, among others. In most studies using cell therapy, pain was reduced or absent, there were no complications and reintervention was not necessary. All studies with cell therapy indicated a reduction in the progression of osteonecrosis of the hip.
Conclusion:Considering the analyzed studies, it was found that autologous bone marrow cell implantation has gained prominence and great relevance in the treatment of osteonecrosis of the hip in people with sickle cell disease, presenting a better clinical outcome and greater efficacy and effectiveness compared with hip arthroplasty. Systematic review record: a study pre-registered in PROSPERO (https://www.crd.york.ac. uk/prospero/display_record.php?ID=CRD42020199505) under the number CDR42020199505, before data collection.
Comparative Assessment of Efficacy and Safety of approved Oral Therapies for Overactive Bladder: A Systematic Review and Network Meta-analysis
Authors: He Wenjuan , Huang Guangliang , Cui Wenyan , Tian Yunfei , Sun Qian , Zhao Xiaojuan , Zhao Yonghong , Li Dan , Liu Xiuju 
Published: February 2023

Abstract
Purpose
To compare the effectiveness and safety of marketed oral drugs for the treatment of overactive bladder.
Methods
Pubmed, Embase, Web of Science, and The Cochrane Register of Clinical Trials databases were systematically searched. The search time frame was from database creation to June 2, 2022, and randomized controlled double-blind trials of oral drugs for overactive bladder were screened. Trials were evaluated for quality using the Cochrane Risk of Bias Assessment Tool, and data were statistically analyzed using Stata 16.0 to compare and rank differences in effectiveness and safety.
Result
A total of 60 randomized controlled double-blind trials were included. Solifenacin 10mg was the most effective in micturitions and incontinence episodes, solifenacin 5/10mg in urgency and nocturia, fesoterodine 8mg in urgency incontinence and oxybutynin 5mg in voided volume/micturition. For safety, mirabegron, vibegron, solifenacin 5mg, extended-release tolterodine 4mg and extended-release oxybutynin 10mg all showed a better incidence of dry mouth; Compared to placebo, only imidafenacin 0.1mg, showed a significantly increased incidence in hypertension, solifenacin 10mg in urinary tract infection, fesoterodine 4/8mg and controlled release darifenacin 15mg in headache.
Conclusion
Solifenacin showed better efficacy. For safety, most anticholinergics were more likely to cause dry mouth and constipation, while β-adrenergic agonists showed an increased incidence of nasopharyngitis. The choice of therapeutic agent should be tailored to the patient's situation in order to find the best balance between efficacy and safety.
Complete genome sequence of wheat yellow stripe polerovirus, a new polerovirus infecting wheat (Triticum aestivum) in China
Authors: Yan Dankan , han kelei , Chen Ying , Ma Chao , Hu Shuzhen , Zhao Wei , Wang Fang 
Published: February 2023

Abstract
Wheat plants with yellow stripes on their leaves were collected in Tai’an City (Shandong province, China). High-throughput sequencing analysis of the collected plants showed that they were coinfected with wheat leaf yellowing-associated virus (WLYaV) and an unidentified polerovirus. The genome of the unidentified virus, tentatively named “wheat yellow stripe-associated virus” (WYSaV), comprises 5,595 nucleotides and contains six open reading frames (ORFs) initiated by AUG and one ORF initiated by AUA, with a typical polerovirus genome structure. Analysis by sequence alignment showed that WYSaV had the highest sequence identity with wheat yellow dwarf virus (WYDV, a tentative member of the Polerovirus genus), with a nucleotide sequence similarity of 87.3% over the whole genome. Except for P3a and the coat protein (CP), for all deduced proteins between WYSaV and the other poleroviruses, the amino acid identity was < 90%. According to phylogenetic evaluation using the RdRp and CP protein sequences, and the complete genome, WYDV, cereal yellow dwarf virus RPS (CYDV-RPS), CYDV-RPV, and barley yellow dwarf virus-GPV are the phylogenetically closest poleroviruses to WYSaV. Thus, WYSaV is proposed as a new member of the genus Polerovirus.
Monkeypox: A review of epidemiological modelling studies and how modelling has led to mechanistic insight
Authors: Korosec Chapin , Banuet-Martinez Marina , Yang Yang , Jafari Behnaz , Kaur Avneet , Butt Zahid A. , Chen Helen H. , Yanushkevich Svetlana , Moyles Iain R. , Heffernan Jane M. 
Published: February 2023

Abstract
Human monkeypox virus (mpox) is a viral zoonosis belonging to the Orthopoxvirus genus of the Poxviridae family that presents with similar symptoms as seen previously in human smallpox patients. mpox is a growing concern internationally with over 80000 cases in non-endemic countries as of December 2022. In this review, we briefly cover the history and origins of mpox and describe its basic virology, noting key differences in mpox viral fitness traits pre and post-2022. We then summarize and critique current knowledge from epidemiological mathematical models, within-host models, and between-host transmission models. We distinguish between models that focus on immunity from vaccination, as well as geography, climatic variables, and animal models. We report various epidemiological parameters, such as the reproduction number R0, in a condensed format for ease of comparison between studies. We focus specifically on how mathematical modelling studies have led to novel mechanistic insight into Monkeypox transmission and pathogenesis. As mpox continues to emerge and is predicted to continue to form subsequent peaks in many historically non-endemic countries, mpox mathematical modelling studies can provide rapid actionable insight into viral dynamics to guide public health measures and mitigation strategies.
Seafloor Geodetic Positioning Models with Diversified Acoustic Delay Estimations Under Different Conditions for Detecting the Sound Speed Variation
Authors: Xue Shuqiang , Yang Yuanxi , Xiao Zhen , Li Jingsen , Yang Wenlong 
Published: February 2023

Abstract
Global Navigation Satellite System–Acoustic (GNSS-A) positioning technique is an important tool for monitoring the submarine tectonic movement and seismic. The submarine positioning accuracy however is seriously affected by the sound speed variation. This contribution investigates the influence of sound speed variation on the seafloor geodetic positioning and proposes diversified acoustic delay models, including two five-parameter models and two three parameter models. It shows that the five-parameter zenith delay model can be degenerated into a three-parameter zenith delay model in the single-point positioning case or under the single-layer sound speed field (SSF) assumption. The proposed zenith delay models are verified by the Japanese opened seafloor geodesy observation-array (SGO-A) data and the sound speed gradient relative to the reference sound speed profile (SSP) is obtained. Experimental tests show that, both the proposed five-parameter zenith delay and three-parameter zenith delay models can achieve a three-dimensional positioning precision at centimeter-level and they can be used to produce a more stable long-term horizontal coordinate time series relative to the GNSS-A ranging combined positioning solver (GARPOS V1.0.0).
Transitioning from the “Three Delays” to a focus on continuity of care: A qualitative analysis of maternal deaths in rural Pakistan and Mozambique
Authors: Vidler Marianne , Kinshella Mai-Lei Woo , Sevene Esperanca , Lewis Gwyneth , Dadelszen Peter , Bhutta Zulfiqar , Group CLIP Working 
Published: February 2023

Abstract
Background: The Three Delays Framework was instrumental in the reduction of maternal mortality leading up to, and during the Millennium Development Goals. However, this paper suggests the original framework might be reconsidered, now that most mothers give birth in facilities, the quality and continuity of the clinical care is of growing importance.
Methods: The paper explores the factors that contributed to maternal deaths in rural Pakistan and Mozambique, using 76 verbal autopsy narratives from the Community Level Interventions for Pre-eclampsia (CLIP) Trial.
Results: Qualitative analysis of these maternal death narratives reveals an interplay of various influences, such as, underlying risks and comorbidities, temporary improvements after seeking care, gaps in quality care in emergencies, convoluted referral systems, and arrival at the final facility in critical condition. Evaluation of these narratives helps to reframe the pathways of maternal mortality beyond a single journey of care-seeking, to update the categories of seeking, reaching and receiving care.
Conclusions: There is a need to reimagine the pioneering “Three Delays Framework” to include focusing on continuity of care and the “Four Critical Connection Points”: (1) between the stages of pregnancy, (2) between families and health care workers, (3) between health care facilities and (4) between multiple care-seeking journeys.
Trial registration: NCT01911494, Date Registered 30/07/2013