bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Optimized Hybridization Approach for in silico High Throughput
Molecular Docking on FPGA Platform
Authors: Jarrah Amin , Lababneh Jawad 
Published: June 2023

Background:
The development process of a new drug should be a subject of continuous
evolution and rapid improvement as drugs are essential to treat a wide range of diseases of
which many are life-threatening. The advances in technology resulted in a novel track in drug discovery
and development known as in silico drug design. The molecular docking phase plays a vital
role in in silico drug development process. In this phase, thousands of 3D conformations of
both the ligand and receptor are generated and the best conformations that create the most stable
drug-receptor complex are determined. The speed in finding accurate and high-quality complexes
depends on the efficiency of the search function in the molecular docking procedure.

Objective:
The objective of this research is to propose and implement a novel hybrid approach
called hABCDE to replace the EMC searching part inside the BUDE docking algorithm. This
helps in reaching the best solution in a much accelerated time and higher solution quality compared
to using the ABC and DE algorithms separately.

Methods:
In this work, we have employed a new approach of hybridization between the Artificial
Bee Colony (ABC) algorithm and the Differential Evolution (DE) algorithm as an alternative searching
part of the Bristol University Docking Engine (BUDE) in order to accelerate the search for higher
quality solutions. Moreover, the proposed docking approach was implemented on Field Programmable
Gate Array (FPGA) parallel platform using Vivado High-Level Synthesis Tool (HLST) in order
to optimize and enhance the execution time and overall efficiency. The NDM-1 protein was used as a
model receptor in our experiments to demonstrate the efficiency of our approach.

Results:
The NDM-1 protein was used as a model receptor in our experiments to demonstrate the
efficiency of our approach. The results showed that the execution time for the BUDE with the new
proposed hybridization approach was improved by 9,236 times.

Conclusion:
Our novel approach was significantly effective to improve the functionality of docking
algorithms (Bristol University Docking Engine (BUDE)).
Quinazoline Analogues as Antiviral Agents
Authors: Krishnarth A Neha 
Published: June 2023

Abstract:
The current COVID-19 outbreak has created an urgent need for innovative and effective antiviral drugs. Quinazoline analogues are an effective antiviral agents. They have shown potent antiviral activity against various preclinical virus types. To date, various quinazoline analogues have been incorporated and tested for their antiviral activity. This review aims to bring together clinical knowledge of the numerous antiviral drug analogues that have been introduced based on their structural recital.
Leonardo Mattos-Cardenas
Authors: Hayakawa Casas José 
Published: June 2023

Es para mi un gran placer y una fuente de genuino intéres, mi estimado colega y amigo, el poder responder a las preguntas que me serán formuladas sobre mi peculiar experiencia personal y sobre el problema, hoy tan importante y aparentemente simple, de la conservación del patrimonio edificado. Solo espero poder ser lo más conciso, directo y útil posible, pensando en especial, en las jóvenes generaciones interesadas en este fascinante tema.
La Conservación es una disciplina que une sofisticadas técnicas en continua evolución con una sólida y profunda formación cultural.
Environmental factors determine the occurrence of pulmonary tuberculosis
Authors: Setiyowati Eppy , Khamida Khamida , Kamariyah Nurul , Setianto Budhi , Hatmanti Netty Mawardah , Bistara Difran Nobel , Wardani Erika Martining 
Published: June 2023

<p><strong><em>Background: </em></strong><em>Environment consisting of residential density, house ventilation, room humidity, and lighting, is regarded as one of the factors causing the transmission of pulmonary tuberculosis (TB). The current research aimed to figure out the environmental factors determining the occurrence of pulmonary TB in Surabaya City. </em></p><p><strong><em>Objectives: </em></strong>the purpose of the current study was to figure out the environmental factor determining the incidents of pulmonary <em>tuberculosis (TB)</em> in Surabaya City<em></em></p><p><strong><em>Methods</em></strong><em> : This was observational research carried out by a cross-sectional approach. People with pulmonary TB registered for treatment at the Perak Timur Community Health Center and Jagir Community Health Center in Surabaya City were recruited as the research population. Meanwhile, the research samples were patients with pulmonary TB in both Community Health Centers. Simple random sampling was utilized to collect 130 patients as respondents. The data obtained were then analyzed using univariate and bivariate logistic regression.</em></p><p><strong><em>Results</em></strong><em>: The bivariate statistical test on the four research variables showed that residential density had OR=0.671, house ventilation had OR=2.874, room humidity had OR=1.231, and house lighting had OR=1.170. Fourth, environmental factors are not the cause of TB disease, because the results of statistical tests show that the OR value is above 0.5</em></p><strong><em>Conclusions</em></strong><em>: It can be concluded that residential density, lighting, and house ventilation did not influence the occurrence of pulmonary tuberculosis. It was more likely that it was caused by factors which do not come from the living environment</em>. Suggestions for future research need to be an air swab examination around the residence of TB patients
The Influence of Greenspace Exposure on Affect in People With and Those Without Schizophrenia: Exploratory Study
Authors: Kangarloo Tairmae , Mote Jasmine , Abplanalp Samuel , Gold Alisa , James Peter , Gard David , Fulford Daniel 
Published: June 2023

Background
Exposure to natural vegetation (ie, “greenspace”) is related to beneficial outcomes, including higher positive and lower negative affect, in individuals with and those without mental health concerns. Researchers have yet to examine dynamic associations between greenspace exposure and affect within individuals over time. Smartphone-based ecological momentary assessment (EMA) and passive sensors (eg, GPS, microphone) allow for frequent sampling of data that may reveal potential moment-to-moment mechanisms through which greenspace exposure impacts mental health.

Objective
In this study, we examined associations between greenspace exposure and affect (both self-reported and inferred through speech) in people with and those without schizophrenia spectrum disorder (SSD) at the daily level using smartphones.

Methods
Twenty people with SSD and 14 healthy controls reported on their current affect 3 times per day over 7 days using smartphone-based EMA. Affect expressed through speech was labeled from ambient audio data collected via the phone’s microphone using Linguistic Inquiry and Word Count (LIWC). Greenspace exposure, defined as the normalized difference vegetation index (NDVI), was quantified based on continuous geo-location data collected from the phone’s GPS.

Results
Overall, people with SSD used significantly more positive affect words (P=.04) and fewer anger words (P=.04) than controls. Groups did not significantly differ in mean EMA-reported positive or negative affect, LIWC total word count, or NDVI exposure. Greater greenspace exposure showed small to moderate associations with lower EMA-reported negative affect across groups. In controls, greenspace exposure on a given day was associated with significantly lower EMA-reported anxiety on that day (b=–0.40, P=.03, 95% CI –0.76 to –0.04) but significantly higher use of negative affect words (b=0.66, P<.001, 95% CI 0.29-1.04). There were no significant associations between greenspace exposure and affect at the daily level among participants with SSD.

Conclusions
Our findings speak to the utility of passive and active smartphone assessments for identifying potential mechanisms through which greenspace exposure influences mental health. We identified preliminary evidence that greenspace exposure could be associated with improved mental health by reducing experiences of negative affect. Future directions will focus on furthering our understanding of the relationship between greenspace exposure and affect on individuals with and those without SSD.
The Impact of Counseling on the Dignity of Older People: Protocol for a Mixed Methods Study
Authors: Hung Ho Yeow , Azman Azlinda , Jamir Singh Paramjit Singh 
Published: June 2023

Background
Psychological counseling is perceived as a treatment that could significantly improve older individuals’ psychological and behavioral functioning. There is a dearth of information on the impact of psychological counseling on preserving dignity and facilitating good aging among older people in Singapore.

Objective
The objectives of this study are as follows: (1) to assess advance care planning among older people and their perception of life and health, end of life, and end-of-life care; (2) to explore older people’s accessibility and receptiveness toward counseling; (3) elucidate older people’s perspectives on counseling and its impact on emotional management and decision-making; (4) to assess older people’s competencies in emotional management; and (5) to propose an intervention model for enhancing older people’s well-being and dignity through psychological counseling in Singapore.

Methods
A mixed method study design involving quantitative and qualitative methods will be used. Older individuals receiving some form of preventive, primary, or long-term care in the community through voluntary welfare organizations from the senior activity centers located in eastern Singapore participated in the qualitative phase. Six older individuals from each senior activity center have been enrolled for the interview phase to explore 6 components: the Advanced Care Planning (ACP) booklet, Trait Meta Mood Scale (TMMS), accessibility and receptiveness toward counseling, and emotional management and decision-making. The ACP, an instrument designed to assess advanced care planning among older individuals, and the TMMS, an instrument developed to measure meta-mood experience and emotional management, were used in the quantitative phase among 100 participants. The data will be analyzed thematically using NVivo version 12, whereas descriptive statistics and a 2-tailed, 1-sample t test will be conducted in SPSS (version 25; IBM Corp) for empirical data analyses.

Results
The qualitative phase, which involves a semistructured interview, has been completed among 20 older individuals aged 66-86 years. Thematic analysis of the data is still ongoing. Meanwhile, the quantitative phase commenced on March 22, 2022, with 100 participants providing signed informed consent to participate in the study. The study is expected to be completed by March 2023.

Conclusions
The mixed methods study will document the current awareness of ACP, accessibility and receptiveness toward counseling, and the potential use of psychological counseling in enhancing well-being and dignity among older people in Singapore. The research findings will benefit policy makers in their decision-making when attempting to mitigate the potential barriers to seeking counseling assistance among older people.

International Registered Report Identifier (IRRID)
DERR1-10.2196/45557
Leveraging Electronic Health Record Technology and Team Care to Address Medication Adherence: Protocol for a Cluster Randomized Controlled Trial
Authors: Blecker Saul , Schoenthaler Antoinette , Martinez Tiffany Rose , Belli Hayley M , Zhao Yunan , Wong Christina , Fitchett Cassidy , Bearnot Harris R , Mann Devin 
Published: June 2023

Background
Low medication adherence is a common cause of high blood pressure but is often unrecognized in clinical practice. Electronic data linkages between electronic health records (EHRs) and pharmacies offer the opportunity to identify low medication adherence, which can be used for interventions at the point of care. We developed a multicomponent intervention that uses linked EHR and pharmacy data to automatically identify patients with elevated blood pressure and low medication adherence. The intervention then combines team-based care with EHR-based workflows to address medication nonadherence.

Objective
This study aims to describe the design of the Leveraging EHR Technology and Team Care to Address Medication Adherence (TEAMLET) trial, which tests the effectiveness of a multicomponent intervention that leverages EHR-based data and team-based care on medication adherence among patients with hypertension.

Methods
TEAMLET is a pragmatic, cluster randomized controlled trial in which 10 primary care practices will be randomized 1:1 to the multicomponent intervention or usual care. We will include all patients with hypertension and low medication adherence who are seen at enrolled practices. The primary outcome is medication adherence, as measured by the proportion of days covered, and the secondary outcome is clinic systolic blood pressure. We will also assess intervention implementation, including adoption, acceptability, fidelity, cost, and sustainability.

Results
As of May 2023, we have randomized 10 primary care practices into the study, with 5 practices assigned to each arm of the trial. The enrollment for the study commenced on October 5, 2022, and the trial is currently ongoing. We anticipate patient recruitment to go through the fall of 2023 and the primary outcomes to be assessed in the fall of 2024.

Conclusions
The TEAMLET trial will evaluate the effectiveness of a multicomponent intervention that leverages EHR-based data and team-based care on medication adherence. If successful, the intervention could offer a scalable approach to address inadequate blood pressure control among millions of patients with hypertension.

Trial Registration
ClinicalTrials.gov NCT05349422; https://clinicaltrials.gov/ct2/show/NCT05349422

International Registered Report Identifier (IRRID)
DERR1-10.2196/47930
Analisis kepuasan pemustaka terhadap kualitas layanan website perpustakaan di masa pandemi COVID-19
Authors: Restanti Anisa Sri , Munjiati Munjiati , Wijayanti Utik Nur , Auliyani Uswatun , Saefudin Saefudin 
Published: June 2023

Introduction: Government policies in suppressing the spread of the COVID-19 pandemic creates a bigger challenge to provide better library services. Library websites become one important service in social distance. This study aims to find out the level of user satisfaction in the utilization of library websites during the COVID-19 pandemic.
Data Collecttion Methods: The paper used a quantitative approach with surveys. Questionnaires are managed based on webqual variables.
Data analysis: The survey data analysis used descriptive statistics with mean value. The mean value is based on the interpretation guidelines.
Results and discussion: Library web statements showed the highest score while library web appearance showed the lowest. The average score of user satisfaction on the utilization of library websites is at a satisfactory level. The highest score is 28,04 on the information quality variable. The lowest score of 18,76 on the usability quality variable and interaction quality showed a score of 23,74.
Conclusions: Based on the results of data analysis on the webqual variable, the level of user satisfaction in the utilization of library website during the COVID-19 pandemic is found in the satisfactory level.
ANALISIS SPASIAL KETERJANGKAUAN RETAILER ROKOK TERHADAP PERILAKU MEROKOK PADA SISWA SEKOLAH MENENGAH ATAS (SMA) DI KEC. WANGI-WANGI DAN WANGIWANGI SELATAN KABUPATEN WAKATOBI
Authors: Muhammad Ihsan Awaluddin  , Supriyati  , Anis Fuad  
Published: June 2023

Background: Indonesia is still the third country with the most active smokers in the world (61.4 million smokers), after China and India. Data on cases of smoking violations at school in 2017 were 64 cases of smoking violations in all high schools in Wangi-Wangi District and 45 cases in high schools in Wangi-Wangi Selatan District and until August 2018 there were 68 reported cases of smoking violations in high school in these 2 subdistricts and is predicted to continue to increase.
Objective: To analyze the spatial relationship between the afford ability of cigarette retailers by high school students on smoking behavior spatially in Wangi-wangi District and South Wangi-wangi District, Wakatobi Regency.
Methods: Type of research is an analytic survey, using a cross sectional study design with consecutive sampling technique. Where the sample is high school students with a sample of 94 people.
Results: The results showed that there was a significant correlation between the affordability of retailers (p-Value = 0.048) with the smoking behavior of high school students PR 2.09 (95% CI 0.015-4.123), and the smoking behavior of friends (p-Value = 0.010) with the smoking behavior of high school students PR 1.82 (95% CI 1,096-13,662), GeoDa spatial regression test shows that retailer’s affordability (p = 0.00922), friend’s smoking behavior (p = 0.00204) and parental smoking behavior (p = 0.03181) shows spatial relation ship with smoking behavior, where the parental smoking behavior variable has weak spatial autocorrelation because its Morran’s index is close to zero.
Conclusion: There is a spatial relationship between the affordability of retailers, friend smoking behavior and smoking behavior of parents with smoking habits of high school students in Wangi-Wangi District and WangiWangi South District, Wakatobi Regency
PENERAPAN CUCI TANGAN PESERTA DIDIK DI RUMAH SAKIT GIGI DAN MULUT UNIVERSITAS GADJAH MADA PROF. SOEDOMO
Authors: Fitrina Rachmadanty Siregar  , Andreasta Meliala  
Published: June 2023

Background: Dental health professionals have potential infection risks during treatment for the patients. Performing good hand hygiene is very important to prevent the transmission of infections including in dental practice. However, various studies have shown that health workers have low compliance to hand hygiene. Some
factors influence the compliance of health workers in hand hygiene practice are knowledge, perceptions, attitudes, workload, and the availability of hand hygiene facilities.
Objective: The aim of the study was to improve the compliance of the dental clerkship students’ hand hygiene practice at UGM Prof. Soedomo Dental Hospital.
Methods: The research design was action research. Quantitative data was collected during the diagnosing action through a questionnaire on knowledge and perceptions of hand hygiene and observation of hand hygiene compliance among 35 students, focus group discussion (FGD) on four students, and evaluating the hand hygiene
facilities for students. The data collected in initial stage was used to determine the planning action, taking action, and evaluation stage.
Results: The hand hygiene compliance of the students increased by 60% after dissemination of hand hygiene standard procedures, hand hygiene training, improving hand hygiene facilities, and increasing the commitment using consent forms before treating patients. The result of the Wilcoxon Signed Rank Test showed a Z value of -4.583 with a p-value of 0.000 (p<0.05).
Conclusion: It can be concluded that the hand hygiene compliance of clerical students in UGM Prof. Soedomo Dental Hospital increase significantly by the policy and management interventions.
EVALUASI PERENCANAAN DAN PENGANGGARAN PROGRAM PROMOTIF DAN PREVENTIF DINAS KESEHATAN KABUPATEN TANA TIDUNG, KALIMANTAN UTARA
Authors: Ranik Diastuti  , Julita Hendrartini  
Published: June 2023

Background: Planning and budgeting are important components of community health efforts. Budget allocation for health in Tana Tidung was small. Budget absorption in health office was also low.
Achievement of some Minimum Service Standard (SPM) indicators still below 60%. This indicates the possibility of problems regarding the quality of planning, budgeting, or implementation of promotive
and preventive programs. Research needs to be done to evaluate the process of planning and budgeting of promotive and preventive program in Tana Tidung district health office.
Objective: To evaluate the process of planning and budgeting of promotive and preventive program in Tana Tidung district health office to be known the obstacles of SPM indicators achievement.
Methods: The type of research is case study research with single case design. Data collected by documentation document review, observation and in-depth interview with 17 employees in health of
fice and primary healthcare centers during the period of March-April Data were analyzed with qualitative method.
Results: Achievement of promotive and preventive program indicators in Tana Tidung district health office influenced by planning, either from human resources, data and information also guidelines
for planning. Budgedting of promotive and preventive programs was ineffective and inefficient to improve achievement of SPM indicators.
Constraints encountered are human resources have not been sufficient in quantity and quality, less communication, lack monitoring and evaluation functions, weak commitment of the programs holders in targets achievement, as well as the commitment of local authorities to promotive and preventive programs that are also weak.
Conclusion: Planning and budgeting of promotive and preventive program had not been able to increase achievement of SPM indicators. Improvement is needed, especially on human resources, data management, policy components and also need a strong commitment to improve the achievement of promotive and preventive program indicators.
PERAN STAKEHOLDER TERHADAP PROGRAM KESEHATAN JIWA DALAM PENANGGULANGAN PASUNG PADA ORANG DENGAN GANGGUAN JIWA (ODGJ) DI KECAMATAN MOYUDAN KABUPATEN SLEMAN
Authors: Syifa Atun Nisa  , Mubasysyir Hasanbasri  , Nunung Priyatni  
Published: June 2023

Background: Mental health problems or mental health disorders are closely related to the physical restraint. Physical restraint on people with mental disorders is due to lack of information about mental health, financial barriers, inadequate access of mental health services especially in rural areas. The participation or role of stakeholder in mental health programs is one of the determinants to prevent the physical restraint on people with mental health disorders (ODGJ).
Objective: This study aimed to find out and explore the role of stakeholders on mental health programs in prevention of physical restraint on people with mental health disorders in Moyudan, Sleman regency.
Methods: This research was a descriptive study with qualitative methods. The research design used was a case study to identify and explore the role of each stakeholder in overcoming shackles in ODGJ in Moyudan District, Sleman Regency. The study used purposive sampling with research subjects totaling 19 people. Data collection is done by in-depth interviews, observation and document review.
Results: All stakeholders have a role in mental health programs to prevent physical restraint on people with mental health disorders. Puskesmas as a key stakeholders have to advocate for other stakeholders. The results of advocacy are political commitment from local government, policy support from Health District Office, Social Welfare District Office, Ghrasia Mental Hospital, Moyudan district and village government. However, the implementation of the advocacy
was not always successful. In this case, family as the main stake holder refused the advocacy. The negative stigma about mental health is one of the problem that is still difficult to deal within the community.
Conclusion: All stakeholders have a role in mental health programs to prevent physical restraint on people with mental health disorders, although not yet optimal.