bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of physical exercises in restoring the health of young children with congenital pathology of the hip joints in rehabilitation centers
Authors: Sushchenko L. , Yakhontova H. , Bobrovnyk L. 
Published: May 2023

The analysis of scientific literature shows that the leading place in the development of methods of restoring the health of young children with congenital pathology of the hip joints in rehabilitation centers is occupied by the use of physical exercises and massage, and the most progressive methods of rehabilitation today are the use of osteopathic techniques and kinesiotaping.
The tasks of using physical exercises to restore the health of young children with congenital hip joint pathology in rehabilitation centers include: prevention and elimination of thigh muscle contracture; formation of hip joints, restoration of their shape, fixation of joints in the position of maximum correction; strengthening of the muscles that produce movement in the hip joints (flexion, extension, abduction, inward rotation); full development of active movements in hip joints; correction of the valgus position of the knee and ankle joints, which occurs during treatment with the use of tires.
The most important task of using physical exercises is to relieve tension and strengthen the muscles of the hip joint, restore the range of motion as much as possible and organize the motor activity of the child for its full and harmonious physical development. Physical exercises, which are divided into general developmental and special, begin to be used from the beginning of a child's life as reflex exercises taking into account his psychomotor development. Special exercises contribute to the improvement of trophic processes in the hip joints, thigh muscles and buttocks. Taking into account the age of the child, passive (up to a year) and active exercises (from 1 to 3 years) are used. Kinesiotherapy in the rehabilitation of children with congenital dislocation of the hip is the main means of forming a healthy joint and the only means of supporting motor development. The use of physical exercises in water is characterized by a positive combination of physical therapy, aqua massage and relaxation. Hydrokinesitherapy for children is the most effective and affordable means of physical development and rehabilitation.
PENGARUH KOMPETENSI PEDAGOGI TERHADAP KINERJA GURU DI SD NEGERI 101788 MARINDAL KABUPATEN DELI SERDANG
Authors: Septiana Sitorus, Sujarwo  
Published: May 2023

Penelitian ini bertujuan untuk mengetahui pengaruh kompetensi pedagogi terhadap kinerja guru di SD Negeri 101788 Marindal Kabupaten Deli Serdang. Jenis penelitian ini adalah survei deskriptif dengan pendekatan kuantitatif.Sampel dalam penelitian ini adalah 22 guru, 3 guru laki-laki dan 19 guru perempuan.Pengumpulan data dalam penelitian dilakukan dengan menggunakan angket, wawancara dan dokumentasi.Angket yang dibagikan dibagi menjadi 2 jenis, yaitu angket kompetensi pedagogi dan angket kinerja guru. Berdasarkan angket kompetensi pedagogi terdapat 19 guru atau 86,4% pada kategori baik dan 3 guru atau 13,6% pada kategori cukup. Berdasarkan angket kinerja guru terdapat 20 guru atau 90,1% pada kategori baik dan 2 guru atau 9,9% pada kategori cukup. Tehnik analisis data dilakukan dengan uji prasyarat analisis data dan uji hipotesis.Uji prasyarat analisis data dilakukan dengan uji normalitas dan uji linearitas. Tehnik pengujian hipotesis yang dilakukan dengan menggunakan analisis regresi sederhana yang diperoleh dari tabel Coefficient nilai konstan (a) sebesar 87,81 dan nilai kompetensi pedagogik (b) diperoleh sebesar 0,22 sehingga jika dibuat kedalam persamaan menjadi Y = 87,81 + 0,22 x yang artinya jika guru tidak memiliki kompetensi pedagogi, maka nilai tetap (constant) kinerja guru adalah 87,81 dan apabila terdapat peningkatan, maka setiap peningkatan 1 % pada Berdasarkan uji t diperoleh nilai thitung > ttabel yaitu 4,012 >1,720 dan nilai 0,001 yaitu nilai < 0,05. Hasil koefisien determinan adalah 4,41% yaitu kompetensi pedagogi mempengaruhi kinerja guru sebesar 4,41%. Dari hasil analisis uji hipotesis dapat disimpulkan bahwa terdapat pengaruh positif dan signifikan antara kompetensi pedagogi dan kinerja guru di SD Negeri 101788 Marindal Kabupaten Deli Serdang.
EFEKTIVITAS MEDIA VIDEO BERBASIS APLIKASI KINEMASTER TERHADAP KEMAMPUAN SISWA MEMAHAMI MATERI PERUBAHAN WUJUD BENDA
Authors: Dara Fitrah Dwi,   Ahmad Alfaroby  
Published: May 2023

Tujuan penelitian ini adalah untuk mengetahui efektivitas penggunaan media audio visual berbasis aplikasi kinemaster dalam pembelajaran ipa dalam memahami perubahan wujud benda pada siswa kelas IV SDN 105360. Penelitian ini merupakan penelitian eksperimen dengan menggunakan pretest dan posttest. Populasi penelitian ini adalah kelas IV SDN 105360 yang terdiri dari 7 kelas dengan jumlah populasi 250 orang siswa. Dari jumlah tersebut ditetapkan sampel 20% yaitu 50 yang masing-masing berjumlah 25 orang siswa. Teknik pengambilan sampel secara acak. Instrument atau alat pengumpulan data yang digunakan untuk mengetahui hasil belajar adalah tes essay. Dari hasil analisis data yang dikeahui bahwa media audio visual berbasis aplikasi kinemaster lebih efektif dibandingkan dengan media konvensional pada siswa kelas IV SDN 105360. Dalam hal ini diperoleh t_hitung 6.81 selanjutnya dikonsultasikan dengan t_tabel pada taraf 0.05 (5%)=0.127 dengan dk = (N + N)-2= 48. Karena t_hitung yang diperoleh lebih besar dari t_tabel diterima. Hal ini membuktikan bahwa pembelajaran ipa dengan materi perubahan wujud dengan menggunakan media audio visual berbasis aplikasi kinemaster lebih efektif dibandingkan dengan media konvensional.
Study on proximate composition and nutritional quality of some farm made fish feed collected from Muktagacha, Trishal and Phulpur upazila in Mymensingh district
Authors: Toppo Narayon , Rana Md Masud , Rahman Md Mamunur , Hossain Md Sazzad 
Published: May 2023

An experiment was conducted to evaluate the feed quality of farm made feed from three upazila of Mymensingh district for four months from July to October, 2015. Fish feed samples were collected from various farms at Muktagacha, Phulpur and Trishal upazila of Mymensingh district. Total 30 feed samples were analyzed to determine the proximate composition and quality of farm made feed. Only one feed sample (F- 27) contains less than 12% moisture found in Trishal upazila. Maximum moisture value (24.53%) was found in feed sample F-13 in Phulpur upazila which indicated that this feed is poor quality compared to others. These may due to lack of maintenance at processing and may be due to improper storage system. Only four feeds were found having more than 25% protein. The analyzed crude protein contents of fish feed varied from 10.85 to 27.30%. The highest protein content was observed in feed (F-20) (27.30%) and the lowest was found in 10.85% in feed (F-22). The mean crude lipid values of the analyzed fish feeds varied from 5.79 to 22.95%. Highest lipid content was observed in 22.95% in feed (F-19). The analyzed mean ash content of fish feeds varied from 8.41 to 20.99%. The fiber content was observed within 4.35-8.20%. Ash content of feed (F-22) was found higher (20.99%) than other feeds. The analyzed nitrogen free extract (soluble carbohydrate) content of farm made fish feeds varied from 18.62 to 43.25%. The highest nitrogen free extract containing feed (F-25) having 43.25% NFE. The findings of this study demonstrated that low quality feeds and ingredients were supplied to the fish farmers by majority of feed traders and the farms with few exceptions were bound to use those ingredients due to their manufacture constraints.
Asian Australas. J. Biosci. Biotechnol. 2017, 2 (1), 1-8
Comparative efficacy of ivermectin (Vermic®), neem and trichlorfon (Negotox®) against humpsore in cattle
Authors: Talukder Milton , Sikder Subrata , Sarker Konica , Paul Ashit Kumar , Amin Mohammad Rohul 
Published: May 2023

The experiment was conducted to evaluate the comparative efficacy of ivermectin, neem and trichlorfon against humpsore in cattle. A total of 2765 cattle from different villages of Barisal and Patuakhali district were selected for the diagnosis of humpsore. The prevalence of humpsore was found to be 7.52% in the southern part of Bangladesh. Out of humpsore infected cattle, twenty five (25) cattle between 2 - 7 years of age and irrespective of sexes having typical lesion on hump and neck were selected for the experiment divided into five equals groups (A, B, C, D and E) and each group consists of 05 cattle. Group A kept as control group. Group B was treated with ivermectin (Vermic® @200 ug/kg body weight subcutaneously on 1th and 14th day), group C with neem ointment (20%) topically twice daily for 25 days and group D with trichlorfon 10% (Negotox®) topically twice daily for 25 days and group E was treated with combined ointment (Neem + Trichlorfon 10%) topically twice daily for 25 days. On the basis of the reduction of sore lesions of cattle in all treated groups, the efficacy of ivermectin, neem, trichlorfon and combined ointment (Neem + Trichlorfon 10%) were found 100%, 57.78%, 64.16% and 82.07% at 28 days of post treatment respectively. The present findings demonstrated that ivermectin was much more effective than others therapeutic trials against humpsore in cattle.
Asian Australas. J. Biosci. Biotechnol. 2017, 2 (1), 68-74
PENGARUH MODEL PEMBELAJARAN INDUKTIF KATA BERGAMBAR TERHADAP HASIL BELAJAR SISWA
Authors: Bastika Ayu , Mujiburrahman Mujiburrahman 
Published: May 2023

Pada pengamatan awal, guru Bahasa Inggris pada SD Integral Luqman Al-Hakim Mataram seringkali menggunakan metode konvensional yaitu metode ceramah. Karena Bahasa Inggris adalah mata pelajaran yang membutuhkan partisipasi aktif siswa untuk mempelajarinya, maka metode ceramah yang lebih bersifat berpusat pada guru tidak tepat untuk digunakan. Sering kali siswa tidak dapat menangkap penjelasan guru. Kebanyakan siswa hanya mendengarkan dan mencatat apa yang dijelaskan oleh guru sedangkan mereka tidak memahami materi pembelajaran itu sendiri. Rumusan masalah dalam penelitian ini adalah: Apakah Ada Pengaruh Model Pembelajaran Induktif Kata Bergambar terhadap Hasil Belajar Siswa Pada Mata Pelajaran Bahasa Inggris Kelas V di SD Integral Luqman Al-Hakim Tahun Ajaran 2017/2018. Tujuan penelitian ini adalah: Untuk mengetahui Apakah Ada Pengaruh Model Pembelajaran Induktif Kata Bergambar terhadap Hasil Belajar Siswa Pada Mata Pelajaran Bahasa Inggris Kelas V Di SD Integral Luqman Al-Hakim Mataram Tahun Ajaran 2017/2018. Populasi dalam penelitian ini adalah siswa kelas V di SD Integral Luqman Al-Hakim Mataram yang berjumlah 65 orang siswa. Karena populasi kurang dari 100 maka penelitian ini menggunakan studi populasi. Rancanagan penelitian menggunakan one-Group pretes-posttes design. Data dikumpulkan dengan menggunakan metode tes sebagai metode pokok sedangkan dokumentasi sebagai metode pelengkap. Tehnik analisis data menggunakan analisis statistik dengan rumus ttes. Hasil analisis diperoleh nilai ttest sebesar 5,170 dan nilai ttabel pada taraf signifikan 5% dengan db = N-1 = 25 lebih besar daripada nilai ttest pada tabel (5,170>2,060), berarti bahwa ditolak dan Ha diterima yang berbunyi: Ada Pengaruh Model Pembelajaran Induktif Kata Bergamabar terhadap Hasil Belajar Siswa Pada Mata Pelajaran Bahasa Inggris Kelas V Di SD Integral Luqman Al- Hakim Mataram Tahun Ajaran 2017/2018, sehingga dapat disimpulkan bahwa hasil penelitian ini “signifikan”. Kata Kunci: Model Pembelajaran Induktif Kata Bergambar, Hasil Belajar.
Universal cutoff for tumor mutational burden in predicting the efficacy of anti-PD-(L)1 therapy for advanced cancers
Authors: Mo Shu-Fen , Cai Zeng-Zhi , Kuai Wen-Hao , Li Xuexin , Chen Yu-Tong 
Published: May 2023

Background: The US Food and Drug Administration (FDA)’s tumor-agnostic approval of pembrolizumab in high tumor mutational burden (TMB-high, i.e., TMB≥10 mut/Mb) cases, based on the data from KEYNOTE-158, has raised considerable concerns among the immuno-oncology community. This study aims to statistically infer the optimal universal cutoff in defining TMB-high that is predictive of the efficacy of anti-PD-(L) 1 therapy in advanced solid tumors.Methods: We integrated MSK-IMPACT TMB data from a public cohort and the objective response rate (ORR) for anti-PD-(L) 1 monotherapy across diverse cancer types in published trials. The optimal TMB cutoff was determined by varying the universal cutoff to define TMB-high across cancer types and examining the cancer-level correlation between objective response rate and the proportion of TMB-high cases. The utility of this cutoff in predicting overall survival (OS) benefits from anti-PD-(L) 1 therapy was then evaluated in a validation cohort of advanced cancers with coupled MSK-IMPACT TMB and OS data. In silico analysis of whole-exome sequencing data from The Cancer Genome Atlas was further employed to assess the generalizability of the identified cutoff among panels comprising several hundred genes.Results: The cancer type-level analysis identified 10 mut/Mb as the optimal cutoff for MSK-IMPACT in defining TMB-high, with the corresponding TMB-high (TMB≥10 mut/Mb) percentage strongly correlated with ORR for PD-(L) 1 blockade across cancer types [correlation coefficient, 0.72 (95% CI, 0.45–0.88)]. This cutoff was also the optimum in defining TMB-high (via MSK-IMPACT) when predicting OS benefits from anti-PD-(L) 1 therapy in the validation cohort. In this cohort, TMB≥10 mut/Mb was associated with significantly improved OS (hazard ratio, 0.58 [95% CI, 0.48–0.71]; p &lt; 0.001). Moreover, in silico analyses revealed excellent agreement of TMB≥10 mut/Mb cases between MSK-IMPACT and the FDA-approved panels and between MSK-IMPACT and various randomly sampled panels.Conclusion: Our study demonstrates that 10 mut/Mb is the optimal, universal cutoff for TMB-high that guides the clinical application of anti-PD-(L) 1 therapy for advanced solid tumors. It also provides rigorous evidence beyond KEYNOTE-158 for the utility of TMB≥10 mut/Mb in predicting the efficacy of PD-(L) 1 blockade in broader settings, which could help to mitigate the challenges in embracing the tumor-agnostic approval of pembrolizumab in TMB-high cases.
Reducing the matrix effect in mass spectral imaging of biofilms using flow-cell culture
Authors: Zhang Yuchen , Plymale Andrew , Son Jiyoung , Huang Qiaoyun , Chen Wenli , Yu Xiao-Ying 
Published: May 2023

The interactions between soil microorganisms and soil minerals play a crucial role in the formation and evolution of minerals and the stability of soil aggregates. Due to the heterogeneity and diversity of the soil environment, the under-standing of the functions of bacterial biofilms in soil minerals at the microscale is limited. A soil mineral-bacterial biofilm system was used as a model in this study, and it was analyzed by time-of-flight secondary ion mass spectrometry (ToF-SIMS) to acquire molecular level information. Static culture in multi-wells and dynamic flow-cell culture in microfluidics of biofilms were investigated. Our results show that more characteristic molecules of biofilms can be observed in SIMS spectra of the flow-cell culture. In contrast, biofilm signature peaks are buried under the mineral components in SIMS spectra in the static culture case. Spectral overlay was used in peak selection prior to performing Principal component analysis (PCA). Comparisons of the PCA results between the static and flow-cell culture show more pronounced molecular features and higher loadings of organic peaks of the dynamic cultured specimens. For example, fatty acids secreted from bacterial biofilm extracellular polymeric substance are likely to be responsible for biofilm dispersal due to mineral treatment up to 48 h. Such findings suggest that the use of microfluidic cells to dynamically culture biofilms be a more suitable method for reducing the matrix effect arisen from the growth medium and minerals as a perturbation fac-tor for improved spectral and multivariate analysis of complex mass spectral data in ToF-SIMS. These results show that the interaction mechanism between biofilms and soil minerals at the molecular level can be better studied using the flow-cell culture and advanced mass spectral imaging techniques like ToF-SIMS.
Causal associations between human gut microbiota and cholelithiasis: a mendelian randomization study
Authors: Li Wei , Ren Ao , Qin Qiong , Zhao Ling , Peng Qiufeng , Ma Ruidong , Luo Shiqiao 
Published: May 2023

BackgroundThere was some evidence that gut microbiota was closely related to cholelithiasis, but the causal relationship between them remained unclear. In this study, we try to use Two-sample Mendelian randomization (MR) to clarify the potential causal relationship between gut microbiota and cholelithiasis.MethodsSummary Genome-Wide Association Studies (GWAS) statistical data for gut microbiota was obtained from MiBioGen, and the data of cholelithiasis was obtained from UK Biobank (UKB). Two-sample MR analyses were performed to assess causalities between gut microbiota and cholelithiasis mainly using the inverse-variance weighted (IVW) method. Sensitivity analyses were used to determine the robustness of the MR results. Reverse MR analyses were performed to examine the reverse causal association.ResultsOur research results, based primarily on the IVW method, support the existence of a causal relationship between nine gut microbial taxa and cholelithiasis. We observed a positive association between Genus Butyrivibrio (p=0.032), Genus Lachnospiraceae_UCG_001 (p=0.015), Genus Ruminococcaceae_NK4A214_group (p=0.003), Genus Ruminococcaceae_UCG_011 (p=0.010) and cholelithiasis, while Order Rhodospirillales (p=0.031), Genus Actinomyces (p=0.010), Genus Phascolarctobacterium (p=0.036), Genus Rikenellaceae_RC9_gutgroup (p=0.023), Genus Ruminococcaceae_UCG_013 (p=0.022) may be associated with a reduced risk of cholelithiasis. We did not find a reverse causal relationship between cholelithiasis and 9 specific gut microbial taxa.ConclusionsThis is the first mendelian randomization study to explore the causalities between specific gut microbiota taxa and cholelithiasis, which may provide new ideas and a theoretical basis for the prevention and treatment of cholelithiasis in the future.
Establishment of a risk prediction model for multidrug-resistant bacteria in deceased organ donors: a retrospective cohort study in China
Authors: Shen Guojie , Zhang Li , Fan Weina , Lv Haifeng , Wang Feifei , Ye Qingqing , Lin Miaozuo , Yu Xia , Cai Hongliu , Wu Xiaoliang 
Published: May 2023

BackgroundMultidrug resistance in bacteria is a serious problem in organ transplantations. This study aimed to identify risk factors and establish a predictive model for screening deceased organ donors for multidrug-resistant (MDR) bacteria.MethodsA retrospective cohort study was conducted at the First Affiliated Hospital of Zhejiang University School of Medicine from July 1, 2019 to December 31, 2022. The univariate and multivariate logistic regression analysis was used to determine independent risk factors associated with MDR bacteria in organ donors. A nomogram was established based on these risk factors. A calibration plot, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA) were used to estimated the model.ResultsIn 164 organ donors, the incidence of MDR bacteria in culture was 29.9%. The duration of antibiotic use ≥3 days (odds ratio [OR] 3.78, 95% confidence interval [CI] 1.62–8.81, p=0.002), length of intensive care unit (ICU) stay per day(OR 1.06, 95% CI 1.02–1.11, p=0.005) and neurosurgery (OR 3.31, 95% CI 1.44–7.58, p=0.005) were significant independent predictive factors for MDR bacteria. The nomogram constructed using these three predictors displayed good predictive ability, with an area under the ROC curve value of 0.79. The calibration curve showed a high consistency between the probabilities and observed values. DCA also revealed the potential clinical usefulness of this nomogram.ConclusionsThe duration of antibiotic use ≥3 days, length of ICU stay and neurosurgery are independent risk factors for MDR bacteria in organ donors. The nomogram can be used to monitor MDR bacteria acquisition risk in organ donors.
High-resolution record of stable isotopes in soil carbonates reveals environmental dynamics in an arid region (central Iran) during the last 32 ka
Authors: Bayat Omid , Karimi Alireza , May Jan-Hendrik , Fattahi Morteza , Wiesenberg Guido L. B. , Egli Markus 
Published: May 2023

Although central Iran is pivotal for palaeoclimatic correlations, palaeoenvironmental data for this region is very sparse and a reliable chronology for pedogenic features is lacking. We therefore tried to answer the question how the environmental conditions and, in particular, the climate developed over time by using the isotopic signatures of pedogenic carbonates. We present a chronology of pedogenic carbonates in association with stable carbon and oxygen isotopes in both the matrix and coating carbonates of a relict palаeosol (Baharan palaeosol) in central Iran to understand the dynamics of environmental changes in this region during the late Quaternary. The palаeosol experienced several episodes of leaching during pedogenesis as reflected in its morphology (carbonate coatings under the rock fractions) and geochemical characteristics (Ba/Sr ratios). The δ18O values of both the matrix and coating carbonates in the upper 60 cm (especially in the upper 20 cm) of the pedon are enriched (∼4‰) compared to the subsoil and are mainly related to the impact of evaporation. Moreover, the δ13C values of the carbonates are in isotopic disequilibrium with the modern vegetation cover (desert shrubs) of the study area and are enriched in different degrees. The carbonates in the top 60 cm are formed by the input of atmospheric CO2 and calcareous dust while deeper carbonates formed in an environment exhibiting a higher contribution of C4 plants. Based on the radiocarbon chronology of carbonate coatings, it seems that three main stages of palaeoenvironmental changes occurred in the region during the last 32 ka. The first stage lasted ca. 5,000 years (between 31.6 and 26.0 ka) and was accompanied by deep leaching under sub-humid climatic conditions and the expansion of C4 plants. Under the dominance of semi-arid conditions during the second stage until the late Holocene, a gradual increase in the δ18O values and aridity occurred in the region. The last phase in the late Holocene was characterised by the establishment of an arid and evaporative environment with a sparse vegetation cover. A climatic correlation using the oxygen isotopic composition of secondary carbonates from the Baharan palaeosol, Soreq Cave (the Levant) and Hoti Cave (Oman; both having speleothems records) suggested a climatic connection between central Iran and the eastern Mediterranean during the late Pleistocene and between central Iran and northern Oman during the late Holocene.