bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimensionality, Factorial Invariance, and Cross-Cultural Differential	Item Functioning of the Short Dark Tetrad (SD4) in Italian, Romanian, and UK	Samples
Authors: Fino Emanuele , Popușoi Simona A. , Holman Andrei C. , Iliceto Paolo , Heym Nadja 
Published: June 2023

Abstract: The present research tested the dimensionality and cross-cultural differential item functioning of the Short Dark Tetrad (SD4; Paulhus et al., 2021 ) in samples of university students (total N = 804) from Italy ( N = 268), Romania ( N = 313), and the United Kingdom ( N = 223), respectively. Multidimensional Item Response Theory was used to model the data and ordinal logistic regression for differential item functioning analyses. The results showed that a four-factor model was the best fit for the data. However, the model showed metric non-invariance between the three samples, as well as non-negligible differential item functioning for several items in each of the four factors, in line with findings from previous research on cultural differences in antagonistic traits. Implications for theory and research are discussed.
Polarimetric Decomposition and Machine Learning‐Based Classification of L‐ and S‐Band Airborne SAR (LS‐ASAR) Data
Authors: Verma Shatakshi , Kumar Shashi , Dsouza Hamish 
Published: June 2023

AbstractThe polarimetric Synthetic Aperture Radar (SAR) data sets have been widely exploited for land use land cover (LULC) classification due to their sensitivity to the structural and dielectric properties of the imaging target. In this study, the potential of fully polarimetric L‐ and S‐band Airborne SAR (LS‐ASAR) data sets were explored for the machine‐learning‐based classification of Urban, Vegetation, Waterbody, and Open Ground. This work was done by utilizing dual‐frequency L‐ and S‐band airborne data of Santa Barbara, California, USA, acquired under the Airborne SAR (LS ASAR) campaign, a precursor airborne mission to the space‐borne NASA‐ISRO (NISAR) mission. The LS‐ASAR polarimetric information was utilized for LULC classification using the SVM classifier. The roll‐invariant Barnes, and eigenvalue/eigenvector‐based Cloude and H/A/Alpha decomposition were implemented to retrieve the scattering parameters. The backscatter response of classes was studied, and separability analysis was done to reduce the misclassification error between six class pairs‐ Vegetation—Urban, Vegetation—Waterbody, Vegetation—Open Ground, Urban—Waterbody, Urban—Open Ground, and Water—Open Ground. The decomposition models failed to achieve the desirable separability index for all six class pairs; consequently, the classification of Barnes, Cloude, H/A/Alpha decomposition showed misclassification between vegetation‐urban class, and waterbody‐open ground class for both L‐ and S‐band data sets. The effort was made toward improving the classification accuracy by integrating the roll‐invariant and eigenvalue‐eigenvector scattering parameters of the multifrequency L‐ and S‐band data set. This method presented the desirable separability index for all class‐pair; eventually highest classification accuracy was achieved i.e. 93.35% ( = 0.91) by significantly reducing the misclassification error between class pairs.
Water Balance Shifts Induced by Multiyear Drought Within the Budyko Framework
Authors: Liu Qiang , Yang Yuting , Liang Liqiao , Yan Denghua , Wang Xuan , Sun Tao , Li Chunhui 
Published: June 2023

AbstractClimate change intensification can induce unprecedented alterations to global hydrological cycling. This study employed the Budyko framework to assess water balance shifts induced by resultant multiyear drought events, selecting 1,258 among 3,347 globally distributed catchments. Here, the precipitation (P) deficit was used to identify long‐term drought, while the Budyko framework was used to explore the impact of long‐term drought on changes in streamflow (Q). Additionally, this study developed a novel method (the trigonometric function decomposition method (TFD method)) to analyze Q change induced by climate and catchment properties changes. Results showed that: (a) long‐term drought has caused catchment property parameter (n) increase (i.e., n is 2.14 and 2.33 during non‐drought period and drought period in 1,258 catchments, respectively), which will alter P partitioning into E and Q; (b) sensitivity analysis presented n is most sensitive to changes in aridity index, while effective rooting depth (Ze) contributed larger magnitude in variability of n; (c) a reduction in the magnitude of Q decreased under a reduction in climatic aridity, which were primarily controlled by climate changes (average value, 80.83%), while asymmetrical effects of Q reduction were induced by catchment property changes and suggested Q reduction were weakened in arid and humid regions, while strengthened in semi‐arid and sub‐humid regions. Together, these factors all indicated that multiyear drought events can significantly alter Q, while the hydrological response to drought events was characterized by complex mechanisms. Clarifying the hydrological response to multiyear drought events will help us better understand how climate change affects water resources.
Impact Evaluation of Water Infrastructure Investments: Methods, Challenges and Demonstration From a Large‐Scale Urban Improvement in Jordan
Authors: Jeuland Marc , Orgill‐Meyer Jennifer , Morgan Seth , Hudner Daniel , Pucilowski Mateusz , Wyatt Alan , Shafei Mohammed , Cajka James , Albert Jeff 
Published: June 2023

AbstractImpact evaluation (IE) of large infrastructure presents numerous challenges, and investments in urban piped water and sanitation are no exception. Here we present methods for more systematic assessment of the implications of such interventions, discussing tradeoffs between validity, relevance and practicality that arise from alternative approaches. Then, to more clearly illustrate the many issues that typically arise in such IEs, we draw on an example application in Zarqa, Jordan, where the Millennium Challenge Corporation invested about US$275 million to upgrade and extend piped water and sewer networks, as well as increase the capacity of the country's largest wastewater treatment plant. The theory of change for the intervention took a systems view of impacts: the project aimed to improve water supply to urban areas while maintaining flows to irrigators through enhanced wastewater reuse. The case adds valuable evidence on the impacts of large infrastructure investments and illustrates well the challenges of capturing spillovers, mitigating study contamination, maintaining statistical power, and determining overall welfare effects, in situations involving diverse market and nonmarket impacts. These limitations notwithstanding, the application highlights the high value of conducting IEs, and why applied researchers should not give up on pragmatic and interdisciplinary collaborations to evaluation in the face of complex interventions.
Fast and Efficient Analysis of Receiving Antennas Enclosed by Variable‐Thickness Radome
Authors: Ke Haiwen , Wang Pengyuan , Li Ji , He Mang 
Published: June 2023

AbstractIn this paper, the full‐wave volume‐surface integral equation (VSIE), the modified surface integration (MSI) method, and the ray‐tracing process are combined to efficiently analyze the electromagnetic performance of receiving antennas enclosed by radome with variable thickness. The mutual interactions between the antenna and the radome are considered by coupling the VSIE and MSI in a nested iterative manner, in which the VSIE is applied to model the complex antenna with composite conductor‐dielectric structure, while the MSI method is used to deal with the large‐size dielectric radome. To improve modeling accuracy of the MSI method for multilayered radome with variable thickness, the ray‐tracing technique is incorporated to calculate the angles of incidence and refraction at each interface and the local thickness of the dielectric wall for each sampling ray and then the local transmission matrix. Numerical results illustrate the accuracy and effectiveness of the proposed method.
Recent advances in the role of miRNAs in post-traumatic stress disorder and traumatic brain injury
Authors: Zhu Ziyu , Huang Xuekang , Du Mengran , Wu Chenrui , Fu Jiayuanyuan , Tan Weilin , Wu Biying , Zhang Jie , Liao Z. B. 
Published: June 2023

AbstractPost-traumatic stress disorder (PTSD) is usually considered a psychiatric disorder upon emotional trauma. However, with the rising number of conflicts and traffic accidents around the world, the incidence of PTSD has skyrocketed along with traumatic brain injury (TBI), a complex neuropathological disease due to external physical force and is also the most common concurrent disease of PTSD. Recently, the overlap between PTSD and TBI is increasingly attracting attention, as it has the potential to stimulate the emergence of novel treatments for both conditions. Of note, treatments exploiting the microRNAs (miRNAs), a well-known class of small non-coding RNAs (ncRNAs), have rapidly gained momentum in many nervous system disorders, given the miRNAs’ multitudinous and key regulatory role in various biological processes, including neural development and normal functioning of the nervous system. Currently, a wealth of studies has elucidated the similarities of PTSD and TBI in pathophysiology and symptoms; however, there is a dearth of discussion with respect to miRNAs in both PTSD and TBI. In this review, we summarize the recent available studies of miRNAs in PTSD and TBI and discuss and highlight promising miRNAs therapeutics for both conditions in the future.
Determination of the effect of abiotic stress on the oxidative potential of edible potato tubers
Authors: Wszelaczyńska Elżbieta , Pobereżny Jarosław , Gościnna Katarzyna , Szczepanek Małgorzata , Tomaszewska-Sowa Magdalena , Lemańczyk Grzegorz , Lisiecki Karol , Trawczyński Cezary , Boguszewska-Mańkowska Dominika , Pietraszko Milena 
Published: June 2023

AbstractStress factors occurring during the growing season and potato storage, can negatively affect the quality of tubers, including an increased tendency to enzymatic darkening. Abiotic stress due to water shortage is a major factor limiting agricultural production. The purpose of the study was to determine the effect of cultivation technology based on the use of biostimulant, hydrogel and irrigation as well as storage on the propensity to darkening and the content of sugars and organic acids. The results show that genotypic and technological variability in interaction with growing season conditions had a significant (p < 0.05) effect on the oxidative potential (OP) of potato tubers. The Denar cultivar, compared to the ‘Gardena’, was characterized by a lower tendency to enzymatic darkening. Application of biostimulant and hydrogel generally contributed to lowering the oxidative potential of the tested cultivars. The application of anti-stress agents had no effect on organic acid content. The long-term storage caused an increase in the content of total sugars (TS) (22%), reducing sugars (RS) (49%), chlorogenic acid (ACH) (11%), and loss of ascorbic acid (AA) (6%) in the tubers which contributed to an increase in the oxidative potential of potato tubers (16%). The correlation coefficients obtained (p < 0.05) confirm the dependence of OP on the concentration of organic acids.
Application of additional three-dimensional materials for education in pediatric anatomy
Authors: Youn Joong Kee , Park Han Sang , Ko Dayoung , Yang Hee-Beom , Kim Hyun-Young , Yoon Hyun Bae 
Published: June 2023

AbstractWe conducted this study to investigate the effects of additional education using 3D visualization (3DV) and 3D printing (3DP) after applying 2D images for anatomical education in normal pediatric structures and congenital anomalies. For the production of 3DV and 3DP of the anatomical structures, computed tomography (CT) images of the four topics (the normal upper/lower abdomen, choledochal cyst, and imperforate anus) were used. Anatomical self-education and tests were administered to a total of 15 third-year medical students with these modules. Following the tests, surveys were conducted in order to evaluate satisfaction from students. In all four topics, there were significant increases in the test results with additional education with 3DV after initial self-study with CT (P < 0.05). The difference in scores was highest for the imperforate anus when 3DV supplemented the self-education. In the survey on the teaching modules, the overall satisfaction scores for 3DV and 3DP were 4.3 and 4.0 out of 5, respectively. When 3DV was added to pediatric abdominal anatomical education, we found an enhancement in understanding of normal structures and congenital anomalies. We can expect the application of 3D materials to become more widely used in anatomical education in various fields.
Nerve conduction studies through landmark based recording and effects of hand length
Authors: Yaranagula Sai Deepak , Koduri Venkata Krishna Chaitanya , Babu P. Suresh , Veligonda Thriveni 
Published: June 2023

AbstractAs per existing guidelines, the distance between stimulator and recording electrodes in nerve conduction studies (NCS) should be the same (fixed) in all the subjects, i.e., it should not be based on anatomical landmarks. However, there are no studies comparing fixed distance recordings with landmark based NCS. We postulated that hand length can influence the NCS parameters in fixed distance recordings and this can be nullified using landmark based recordings. To test this theory, we performed NCS in 48 normal subjects as per standard guidelines (standard protocol) and then compared it to NCS with ulnar styloid as the landmark (modified protocol). NCS were performed on median and ulnar nerves of the right upper limb. Three motor NCS parameters including distal latency, compound muscle action potential (CMAP) amplitudes and nerve conduction velocities were measured. Sensory nerve action potential (SNAP) amplitudes and conduction velocities were the two sensory parameters measured. On analysis, ulnar motor conduction velocity was the only parameter affected by hand length in both standard and modified protocols. Modified protocol did not have any additional advantage to the standard protocol advised by NDTF. We conclude that the NDTF guidelines are therefore reasonable when considering the effects of hand length. Possible reasons for this result including anatomical and anthropometric explanations are discussed.
Clinical and radiological efficacy of spino-pelvic fixation in the treatment of neuromuscular scoliosis
Authors: Yang Jae Hyuk , Kim Hong Jin , Chang Dong-Gune , Nam Yunjin , Park Gi Seul , Na Dong Gyoon , Suh Seung Woo 
Published: June 2023

AbstractPelvic fixation is performed to obtain proper coronal and sagittal alignment when the pelvic obliquity is more than 15º in patients with neuromuscular scoliosis (NMS). Since many NMS patients were wheelchair or bed-ridden status, there has been controversy on the effect of pelvic fixation. Therefore, the purpose of this study is to analyze the effects of pelvic fixation on correction of spinal deformity and quality of life (QoL) in NMS patients. A total of 77 NMS patients who underwent deformity correction were divided into three groups and retrospectively analyzed preoperatively, postoperatively, and at 2-year follow-up: pelvic fixation group (Group A, n = 16), fixed to S1 (Group B, n = 33), and fixed to L5 (Group C, n = 28). The correction rate of scoliosis was 60.0%, 58.0%, and 56.7% in groups A, B, and C, respectively, with no statistical difference (P > 0.05). The correction rate of pelvic obliquity was 61.3%, 42.8%, and 57.5% in respective groups A, B, and C, with no significance (P > 0.05). The correction loss of scoliosis and pelvic obliquity showed no statistical significance between three groups for 2-year follow-up (all Ps > 0.05). There were no significant differences regarding clinical outcomes and postoperative complications among the three groups (all Ps > 0.05). Therefore, pelvic fixation using iliac screws is not substantially influencing radiological and clinical outcomes in the patients with NMS.
Mechanisms of synergistic suppression of ALK-positive lung cancer cell growth by the combination of ALK and SHP2 inhibitors
Authors: Berry M. A. , Bland A. R. , Ashton J. C. 
Published: June 2023

AbstractLung cancer is a major cause of cancer-related deaths. Alectinib is the first line of treatment for patients with ALK-positive lung cancer, but the survival rate beyond 2–3 years is low. Co-targeting secondary oncogenic drivers such as SHP2 is a potential strategy for improving drug efficacy. This is because SHP2 is expressed ubiquitously, but ALK expression is largely restricted to cancer cells. Thus, the combination of ALK and SHP2 inhibitors may provide a way to restrict synergistic cytotoxicity to cancer cells only, by reducing the dose of SHP2 inhibitors required for anticancer action and minimising SHP2-dependent systemic toxicity. The objective of this study was to investigate whether the combination of a SHP2 inhibitor (SHP099) with alectinib would synergistically suppress the growth of ALK-positive lung cancer cells. Our results demonstrated that the drug combination significantly and synergistically decreased cell viability at relatively low concentrations in ALK-positive H3122 and H2228 cells, due to G1 cell cycle arrest and increased apoptosis because of suppressed downstream RAS/MAPK signalling. The drug combination also induced the expression of mediators of the intrinsic apoptotic pathway, Bim and cleaved caspase-3, and modulated the expression of cell cycle mediators cyclin D1, cyclin B1, and phosphorylated CDK1.
Modelling ligand depletion for simultaneous affinity and binding site quantification on cells and tissue
Authors: Weber Judith , Djurberg Klara , Lundsten Salomonsson Sara , Kamprath Maria , Hoehne Aileen , Westin Hadis , Vergara Fernanda , Bondza Sina 
Published: June 2023

AbstractThe quantification of the number of targets in biological systems is an important parameter to assess the suitability of surface markers as targets for drugs, drug delivery and medical imaging. Likewise, quantifying the interaction with the target in terms of affinity and binding kinetics is essential during drug development. Commonly used approaches to quantify membrane antigens on live cells are based on manual saturation techniques that are labour-intensive, require careful calibration of the generated signal and do not quantify the binding rates. Here, we present how measuring interactions in real-time on live cells and tissue under ligand depletion conditions can be used to simultaneously quantify the kinetic binding parameters as well as the number of available binding sites in a biological system. Suitable assay design was explored with simulated data and feasibility of the method verified with experimental data for exemplary low molecular weight peptide and antibody radiotracers as well as fluorescent antibodies. In addition to revealing the number of accessible target sites and improving the accuracy of binding kinetics and affinities, the presented method does not require knowledge about the absolute signal generated per ligand molecule. This enables a simplified workflow for use with both radioligands and fluorescent binders.
Attention and schema violations of real world scenes differentially modulate time perception
Authors: Tachmatzidou Ourania , Vatakis Argiro 
Published: June 2023

AbstractIn the real world, object arrangement follows a number of rules. Some of the rules pertain to the spatial relations between objects and scenes (i.e., syntactic rules) and others about the contextual relations (i.e., semantic rules). Research has shown that violation of semantic rules influences interval timing with the duration of scenes containing such violations to be overestimated as compared to scenes with no violations. However, no study has yet investigated whether both semantic and syntactic violations can affect timing in the same way. Furthermore, it is unclear whether the effect of scene violations on timing is due to attentional or other cognitive accounts. Using an oddball paradigm and real-world scenes with or without semantic and syntactic violations, we conducted two experiments on whether time dilation will be obtained in the presence of any type of scene violation and the role of attention in any such effect. Our results from Experiment 1 showed that time dilation indeed occurred in the presence of syntactic violations, while time compression was observed for semantic violations. In Experiment 2, we further investigated whether these estimations were driven by attentional accounts, by utilizing a contrast manipulation of the target objects. The results showed that an increased contrast led to duration overestimation for both semantic and syntactic oddballs. Together, our results indicate that scene violations differentially affect timing due to violation processing differences and, moreover, their effect on timing seems to be sensitive to attentional manipulations such as target contrast.
Design and fabrication of a super-wideband transparent antenna implanted on a solar cell substrate
Authors: Rohaninezhad Mohammadreza , Jalali Asadabadi Meysam , Ghobadi Changiz , Nourinia Javad 
Published: June 2023

AbstractIn this study, an antenna with transparent super wideband CPW technology has been designed and built with the combination of solar panels for use in wireless communication equipment and systems that require mobile power. The transparency value of the antenna is 63.3%, which is an acceptable value for the optimal use of sunlight. The proposed antenna was designed and measured on a plexi-glass substrate with a dielectric constant of$${{\varvec{\upvarepsilon}}}_{{\varvec{r}}}=4.4$$εr=4.4and various thicknesses, the proposed antenna was designed and measured. The copper sheet has a high electrical conductivity and therefore it was selected for the antenna's radiating component as compared to earlier techniques that employed metal oxide. All simulations were done with CST microwave studio software and frequency domain solver. The results indicated that the antenna's operating frequency ranges from 2 to 32 GHz. The results of the computations indicated that the antenna's peak gain and peak efficiency are 8.1 dB and 90%, respectively. Various multiple-input and multiple-output (MIMO) performance parameters, including the envelope correlation coefficient (ECC), diversity gain (DG), average effective gain (MEG), total active reflection coefficient (TARC), and channel capacity loss (CCL), were analyzed to demonstrate the antenna's performance.