bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality measures for palliative care in patients living with cancer in low- and middle-income countries: a scoping review protocol
Authors: Motlana M. K. T. N. , Makhunga S. E. , Jafta N. , Ginindza T. G. 
Published: May 2023

Abstract
Introduction
Quality assessment is a critical component of determining the value of medical services, including palliative care. The utilisation of palliative care quality measures could assist in assessing the degree to which patients living with cancer conform to best practice of palliative care, identifying gaps and monitoring changes in cancer care delivery models in different setting. This scoping review aims to map the available data on the usage of palliative care quality indicators that are relevant to cancer patients in low- and middle-income countries (LMICs).

Methods
To structure this study, we will use the framework developed by Arksey and O’Malley, the Levac et al. recommendations and the Joanna Briggs Institute recommendations. We will search EBSCOHost, Web of Science, ProQuest One Academic, MEDLINE and Google Scholar for evidence on palliative care quality measures applicable for patients living with cancer published from inception till 2022. We will search grey literature in the form of dissertations, conference proceedings and websites of international organisations such as the World Health Organisation (WHO) reporting palliative care quality measures applicable to patients living with cancer in LMICs.

Discussion
The purpose of this study is to establish the extent of existing research on the palliative care quality measures in LMICs. Although palliative care is still a new phenomenon, understanding of the palliative care quality measures applicable for cancer patients will assist to improve care across all components of health systems.

Ethics and dissemination
No ethical approval is required for the study as the data collection and results of the proposed scoping review will be conducted and disseminated electronically using peer-reviewed journals, print and presentations at scientific conferences and stakeholder presentations.
The impact of technology systems and level of support in digital mental health interventions: a secondary meta-analysis
Authors: Sasseville Maxime , LeBlanc Annie , Tchuente Jack , Boucher Mylène , Dugas Michèle , Gisèle Mbemba , Barony Romina , Chouinard Maud-Christine , Beaulieu Marianne , Beaudet Nicolas , Skidmore Becky , Cholette Pascale , Aspiros Christine , Larouche Alain , Chabot Guylaine , Gagnon Marie-Pierre 
Published: May 2023

AbstractBackgroundThe majority of people with a chronic disease (e.g., diabetes, hypertension, COPD) have more than one concurrent condition and are also at higher risk for developing comorbidities in mental health, including anxiety and depression. There is an urgent need for more relevant and accurate data on digital interventions in this area to prepare for an increase demand for mental health services. The aim of this study was to conduct a meta-analysis of the digital mental health interventions for people with comorbid physical and mental chronic diseases to compare the effect of technology systems and level of support.MethodsThis secondary meta-analysis follows a rapid review of systematic reviews, a virtual workshop with knowledge users to identify research questions and a modified Delphi study to guide research methods: What types of digital health interventions (according to a recognized categorization) are the most effective for the management of concomitant mental health and chronic disease conditions in adults? We conducted a secondary analysis of the primary studies identified in the rapid review. Two reviewers independently screened the titles and abstracts and applied inclusion criteria: RCT design using a digital mental health intervention in a population of adults with another chronic condition, published after 2010 in French or English, and including an outcome measurement of anxiety or depression.ResultsSeven hundred eight primary studies were extracted from the systematic reviews and 84 primary studies met the inclusion criteria Digital mental health interventions were significantly more effective than in-person care for both anxiety and depression outcomes. Online messaging was the most effective technology to improve anxiety and depression scores; however, all technology types were effective. Interventions partially supported by healthcare professionals were more effective than self-administered.ConclusionsWhile our meta-analysis identifies digital intervention’s characteristics are associated with better effectiveness, all technologies and levels of support could be used considering implementation context and population.Trial registrationThe protocol for this review is registered in the National Collaborating Centre for Methods and Tools (NCCMT) COVID-19 Rapid Evidence Service (ID 75).
Lymph nodes primary staging of colorectal cancer in 18F-FDG PET/MRI: a systematic review and meta-analysis
Authors: Ren Qingwei , Chen Yanyan , Shao Xuejun , Guo Lanzhong , Xu Xinxin 
Published: May 2023

Abstract
Objective
To assess the diagnostic efficacy of 18F-FDG PET/MRI for lymph node (LN) metastasis primary staging in patients with colorectal cancer (CRC).

Methods
This study was conducted and reported in accordance with the PRISMA-DTA statement. Electronic databases (PubMed, Embase, Cochrane Library) were searched for studies on 18F-FDG PET/MRI for diagnosing LN metastasis. The pooled sensitivity (SEN), specificity (SPE), and area under the curve (AUC) were applied to assess the diagnostic performance. Heterogeneity was identified and processed using meta-regression and sensitivity analysis. All data analyses were performed via STATA 15 and Meta-Disc 1.4 software.

Results
There were finally 7 studies included, involving a total of 184 patients. The Spearman rank correlation coefficient was 0.108 (P = 0.818), with no threshold-effect observed. The pooled SEN was 0.81 (95%CI 0.66–0.90) and the SPE was 0.89 (95% CI 0.73–0.96). In sub-groups, prospective groups demonstrated to have the highest SEN of 0.92 (95%CI 0.79–1.00). The studies conducted by Catalano et al. and Kang et al. were considered to be potential sources of heterogeneity.

Conclusion
18F-FDG PET/MRI has shown remarkable diagnostic performance in identification of LN metastases in newly diagnosed CRC patients. It would be of great application value for the primary staging of CRC lymph node metastases.
Serum metabolic profile and metabolome genome-wide association study in chicken
Authors: Tian Jing , Zhu Xiaoning , Wu Hanyu , Wang Yuzhe , Hu Xiaoxiang 
Published: May 2023

Abstract
Background
Chickens provide globally important livestock products. Understanding the genetic and molecular mechanisms underpinning chicken economic traits is crucial for improving their selective breeding. Influenced by a combination of genetic and environmental factors, metabolites are the ultimate expression of physiological processes and can provide key insights into livestock economic traits. However, the serum metabolite profile and genetic architecture of the metabolome in chickens have not been well studied.

Results
Here, comprehensive metabolome detection was performed using non-targeted LC–MS/MS on serum from a chicken advanced intercross line (AIL). In total, 7,191 metabolites were used to construct a chicken serum metabolomics dataset and to comprehensively characterize the serum metabolism of the chicken AIL population. Regulatory loci affecting metabolites were identified in a metabolome genome-wide association study (mGWAS). There were 10,061 significant SNPs associated with 253 metabolites that were widely distributed across the entire chicken genome. Many functional genes affect metabolite synthesis, metabolism, and regulation. We highlight the key roles of TDH and AASS in amino acids, and ABCB1 and CD36 in lipids.

Conclusions
We constructed a chicken serum metabolite dataset containing 7,191 metabolites to provide a reference for future chicken metabolome characterization work.
Meanwhile, we used mGWAS to analyze the genetic basis of chicken metabolic traits and metabolites and to improve chicken breeding.
Food and the prison environment: a meta-ethnography of global first-hand experiences of food, meals and eating in custody
Authors: Woods-Brown Clair , Hunt Kate , Sweeting Helen 
Published: May 2023

Abstract
Background
Prison foodways offer a unique opportunity to improve the physical and mental health and wellbeing of an underserved population, yet prison food is often rejected in favour of ‘junk’ food. Improved understanding of the meanings of food in prison is necessary to inform prison food policy and enhance the prison environment.

Results
A meta-ethnographic synthesis of 27 papers integrated first-hand experiences of food in prison from 10 different countries. The lived experience for most in custody is of poor-quality prison-issued meals, necessarily consumed at a time and place at odds with socio-cultural norms. Beyond nutrition, food carries clear symbolic meanings in prison; through everyday food activities in prison, especially cooking, empowerment, participation, agency and identity are negotiated and performed. Cooking (with others or alone) can reduce anxiety and depression and increase feelings of self-efficacy and resilience in a socially, psychologically, and financially disadvantaged population. Integrating cooking and sharing food into the routine of prison life strengthens the skills and resources available to prisoners, empowering them as they move from the prison environment to the community.

Conclusions
The potential of food to enhance the prison environment and support improvements in prisoner health and wellbeing is limited when the nutritional content is inadequate and/or where food is served and eaten impacts negatively on human dignity. Prison policy which provides opportunities for cooking and sharing food that better reflects familial and cultural identity has the potential to improve relationships, increase self-esteem, build and maintain life skills needed for reintegration.
Examining the experiences of pediatric mental health care providers during the early stage of the COVID-19 pandemic
Authors: Bright Katherine , Cullen Emma , Conlon Olivia , Zulla Rosslynn T. , Nicholas David B. , Dimitropoulos Gina 
Published: May 2023

Abstract
Background
The COVID-19 pandemic fundamentally impacted the way that mental health services were provided. In order to prevent the spread of infection, many new public health precautions, including mandated use of masks, quarantine and isolation, and closures of many in-person activities, were implemented. Public health mandates made it necessary for mental health services to immediately shift their mode of delivery, creating increased confusion and stress for mental health providers. The objective of this study is to understand the impact of pandemics on the clinical and personal lives of mental health providers working with children during the early months of the COVID-19 pandemic, March -June 2020.

Methods
Mental health providers (n = 98) were recruited using purposive sampling from a public health service in Canada. Using qualitative methods, semi-structured focus groups were conducted to understand the experiences of mental health service providers during the beginning of the COVID-19 pandemic.

Results
Data from the focus groups were analysed and three main themes emerged: (1) shift to virtual delivery and working from home; (2) concerns about working in person; (3) exhaustion and stress from working through the pandemic.

Discussion
This study gave voice to mental health providers as they provided continuity of care throughout the uncertain early months of the pandemic. The results provide insight into the impact times of crisis have on mental health providers, as well as provide practical considerations for the future in terms of supervision and feedback mechanisms to validate experiences.
Application of microservices patterns to big data systems
Authors: Ataei Pouya , Staegemann Daniel 
Published: May 2023

AbstractThe panorama of data is ever evolving, and big data has emerged to become one of the most hyped terms in the industry. Today, users are the perpetual producers of data that if gleaned and crunched, have the potential to reveal game-changing patterns. This has introduced an important shift regarding the role of data in organizations and many strive to harness to power of this new material. Howbeit, institutionalizing data is not an easy task and requires the absorption of a great deal of complexity. According to the literature, it is estimated that only 13% of organizations succeeded in delivering on their data strategy. Among the root challenges, big data system development and data architecture are prominent. To this end, this study aims to facilitate data architecture and big data system development by applying well-established patterns of microservices architecture to big data systems. This objective is achieved by two systematic literature reviews, and infusion of results through thematic synthesis. The result of this work is a series of theories that explicates how microservices patterns could be useful for big data systems. These theories are then validated through expert opinion gathering with 7 experts from the industry. The findings emerged from this study indicates that big data architectures can benefit from many principles and patterns of microservices architecture.
Scenic routing navigation using property valuation
Authors: Rishe Naphtali , Amini M. Hadi , Adjouadi Malek 
Published: May 2023

AbstractExtensive prior work has provided methods for the optimization of routing based on weights assigned to travel duration, and/or travel cost, and/or the distance traveled. Routing can be in various modalities, such as by car, on foot, by bicycle, via public transit, or by boat. A typical method of routing involves building a graph comprised of street segments, assigning a normalized weighted value to each segment, and then applying the weighted-shorted path algorithm to the graph in order to find the best route. Some users desire that the routing suggestion include consideration pertaining to the scenic-architectural quality of the path. For example, a user may seek a leisure walk via what they might deem as visually attractive architecture. Here, we are proposing a method to quantify such user preferences and scenic quality and to augment the standard routing methods by giving weight to the scenic quality. That is, instead of suggesting merely the time and cost-optimal route, we will find the best route that is tailored towards the user’s scenic quality preferences as an additional criterion to the time and cost. The proposed method uniquely weighs the scenic interest or residential street segments based on the property valuation data.
Sedimentary diversity of the 2011 Tohoku-oki tsunami deposits on the Sendai coastal plain and the northern coast of Fukushima Prefecture, Japan
Authors: Matsumoto Dan , Sawai Yuki , Tanigawa Koichiro , Namegaya Yuichi , Shishikura Masanobu , Kagohara Kyoko , Fujiwara Osamu , Shinozaki Tetsuya 
Published: May 2023

AbstractThis paper documents the sedimentary characteristics of the widespread deposits associated with the 2011 Tohoku-oki tsunami on the lowlands along the Pacific coast of the Sendai and Fukushima regions, northern Japan, and observed tsunami inundation depths. In eight areas of the region, field observation was carried out at a total of 123 locations and sampling at a total of 49 locations. Grain-size analysis and soft X-ray imaging reveal that the tsunami deposits are usually composed of sheetlike sandy beds and generally show landward-thinning and landward-fining trends and a landward increase in mud content, although site-specific distributional patterns are apparent along each transect. These thickness and grain-size patterns indicate a landward decrease in flow capacity. This information on the sedimentology of tsunami deposits and observed inundation depths will assist with the identification of paleo-tsunami deposits in the geological record and provide valuable constraints for mathematical analyses of tsunami hydraulic conditions related to sedimentary characteristics.
Characterization of antioxidant Houttuynia cordata extracts loaded polyurethane nanofibers
Authors: Chen Mei Xi , Haider Md. Kaiser , Kim Ick Soo , Lee Jung-Soon 
Published: May 2023

AbstractHerein, we analyzed total polyphenol content, total flavonoid content, and the antioxidant activity of the ethanol and distilled water extracted Houttuynia cordata perennial herb. Later, we investigated the possibility of producing Houttuynia cordata extract (HCE) loaded Polyurethane (PU) nanofibers via the electrospinning technique. The analysis confirmed that the total polyphenol, total flavonoid content, and antioxidant activity of the ethanol extracted HCE were higher than the distilled water extracted HCE. Therefore, the ethanol extracted HCE was used to prepare HCE/PU nanofibers by varying concentrations of HCE and PU. The HCE/PU nanofibers showed a mixed pattern of beads and fibers at a PU concentration of 10 wt%. However, at 12 wt% PU concentration, relatively uniform nanofibers with an average diameter of about 200 nm were formed at 1.0% and 1.5 wt% of HCE. The successful incorporation of HCE in PU nanofibrous matrix was confirmed by the presence of its characteristic bands in Fourier transform infrared (FTIR) and X-ray diffraction (XRD) spectra. The addition of HCE increased the crystallinity, the amount of heat required for pyrolysis, and the thermal stability of HCE/PU nanofibers, which must be credited to the HCE-derived quercitrin and quercetin crystallite solids.
Self-assembled peptide-substance P hydrogels alleviate inflammation and ameliorate the cartilage regeneration in knee osteoarthritis
Authors: Kim Sang Jun , Kim Ji Eun , Choe Goeun , Song Da Hyun , Kim Sun Jeong , Kim Tae Hee , Yoo Jin , Kim Soo Hyun , Jung Youngmee 
Published: May 2023

Abstract

Background
Self-assembled peptide (SAP)-substance P (SP) hydrogels can be retained in the joint cavity longer than SP alone, and they can alleviate inflammation and ameliorate cartilage regeneration in knee osteoarthritis (OA). We conducted a preclinical study using diverse animal models of OA and an in vitro study using human synoviocytes and patient-derived synovial fluids to demonstrate the effect of SAP-SP complex on the inflammation and cartilage regeneration.

Methods
Surgical induction OA model was prepared with New Zealand white female rabbits and chemical induction, and naturally occurring OA models were prepared using Dunkin Hartely female guinea pigs. The SAP-SP complex or control (SAP, SP, or saline) was injected into the joint cavities in each model. We performed micro-computed tomography (Micro-CT) analysis, histological evaluation, immunofluorescent analysis, and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling (TUNEL) assay and analyzed the recruitment of intrinsic mesenchymal stem cells (MSCs), macrophage activity, and inflammatory cytokine in each OA model. Human synoviocytes were cultured in synovial fluid extracted from human OA knee joints injected with SAP-SP complexes or other controls. Proliferative capacity and inflammatory cytokine levels were analyzed.

Results
Alleviation of inflammation, inhibition of apoptosis, and enhancement of intrinsic MSCs have been established in the SAP-SP group in diverse animal models. Furthermore, the inflammatory effects on human samples were examined in synoviocytes and synovial fluid from patients with OA. In this study, we observed that SAP-SP showed anti-inflammatory action in OA conditions and increased cartilage regeneration by recruiting intrinsic MSCs, inhibiting progression of OA.

Conclusions
These therapeutic effects have been validated in diverse OA models, including rabbits, Dunkin Hartley guinea pigs, and human synoviocytes. Therefore, we propose that SAP-SP may be an effective injectable therapeutic agent for treating OA.

Graphical Abstract
In this manuscript, we report a preclinical study of novel self-assembled peptide (SAP)-substance P (SP) hydrogels with diverse animal models and human synoviocytes and it displays anti-inflammatory effects, apoptosis inhibition, intrinsic mesenchymal stem cells recruitments and cartilage regeneration
Sovereign default network and currency risk premia
Authors: Yang Lu , Yang Lei , Cui Xue 
Published: May 2023

AbstractWe construct a sovereign default network by employing high-dimensional vector autoregressions obtained by analyzing connectedness in sovereign credit default swap markets. We develop four measures of centrality, namely, degree, betweenness, closeness, and eigenvector centralities, to detect whether network properties drive the currency risk premia. We observe that closeness and betweenness centralities can negatively drive currency excess returns but do not exhibit a relationship with forward spread. Thus, our developed network centralities are independent of an unconditional carry trade risk factor. Based on our findings, we develop a trading strategy by taking a long position on peripheral countries’ currencies and a short position on core countries’ currencies. The aforementioned strategy generates a higher Sharpe ratio than the currency momentum strategy. Our proposed strategy is robust to foreign exchange regimes and the coronavirus disease 2019 pandemic.
Patient and clinician-reported experiences of using electronic patient reported outcome measures (ePROMs) as part of routine cancer care
Authors: Payne Amelia , Horne Ashley , Bayman Neil , Blackhall Fiona , Bostock Layla , Chan Clara , Coote Joanna , Eaton Marie , Fenemore Jacqueline , Gomes Fabio , Halkyard Emma , Harris Margaret , Lindsay Colin , McEntee Delyth , Neal Hilary , Pemberton Laura , Sheikh Hamid , Woolf David , Price James , Yorke Janelle , Faivre-Finn Corinne 
Published: May 2023

Abstract
Background
Cancer and its treatment can have significant impacts on health status, quality of life and functioning of patients. Direct information from patients regarding these aspects can be collected via electronic platforms in the form of electronic Patient Reported Outcome Measures (ePROMs). Research has shown that the use of ePROMS in cancer care leads to improved communication, better symptom control, prolonged survival and a reduction in hospital admissions and emergency department attendance. Acceptability and feasibility of routine ePROM collection has been reported by both patients and clinicians but to date their use has predominantly been limited to clinical trials. MyChristie-MyHealth is an initiative from a UK comprehensive cancer centre The Christie NHS Foundation Trust which incorporates the regular collection of ePROMs into routine cancer care. This study, carried out as part of a service evaluation, explores patient and clinician experiences of using the MyChristie-MyHealth ePROMs service.

Results
100 patients with lung and head and neck cancers completed a Patient Reported Experience questionnaire. All patients reported that MyChristie-MyHealth was easy to understand and, almost all found it timely to complete and easy to follow. Most patients (82%) reported it improved their communication with their oncology team and helped them to feel more involved with their care (88%). A large proportion of clinicians (8/11) felt ePROMs helped communication with their patients and over half (6/10) felt they led to consultations being more patient focused. Clinicians also felt that the use of ePROMs resulted in patients being more engaged in consultations (7/11) and their cancer care in general (5/11). Five clinicians reported that the use of ePROMs altered their clinical decision making.

Conclusions
Regular ePROMs collection as part of routine cancer care is acceptable to both patients and clinicians. Both patients and clinicians feel their use improved communication and increased the feeling of patient involvement with their care. Further work is needed to explore the experiences of patients that did not complete the ePROMs as part of the initiative and to continue to optimize the service for both patients and clinicians.