bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEKTIVITAS SITUS KEJARCITA: MEDIA DAN ASESMEN BELAJAR GRATIS UNTUK SISWA SEKOLAH DASAR [THE EFFECTIVENESS OF KEJARCITA WEBSITE: FREE LEARNING MEDIA AND ASSESSMENT FOR ELEMENTARY SCHOOL STUDENTS]
Authors: Samsoedin Susiana , Suciati Suciati 
Published: January 2023

<strong>Abstract</strong><p class="abstrak">This research and development study aims to increase the use of websites in learning for elementary school students through free features of video media and learning assessments in the form of question banks and quizzes. The variables studied were the appearance, effectiveness, practicality, and satisfaction of using the features on Kejarcita website. Website revisions were conducted after validation from experts and field trials that involved 349 students and 12 teachers of SD Mahabodhi Vidya and SD Muhammadiyah 6. The expert validation result showed that the website as a learning resource is sufficient. Literacy and numeracy assessments as the indicator of effectiveness are considered quite effective with a percentage of 60% on literacy and 56% on numeracy. The website shows 82% effectiveness from the teacher's side and 81% from the students’ side. The practical results of the website are 77% from the students’ side and 79% from the teachers’ side. The satisfaction shows 79% from the teacher's side. It is concluded Kejarcita website after revision is considered effective, practical and provides user satisfaction.</p><p class="abstrak"><strong>Bahasa Indonesia Abstrak</strong></p><p>Penelitian pengembangan ini bertujuan untuk meningkatkan penggunaan <em>website</em> untuk pembelajaran anak-anak sekolah dasar dengan menggunakan fitur gratis berupa video dan asesmen dalam bentuk bank soal dan kuis. Variabel yang diteliti adalah tampilan, efektivitas, kepraktisan, dan kepuasan penggunaan fitur pada <em>website Kejarcita</em>. Revisi <em>website</em> dilakukan setelah divalidasi oleh pakar, dan uji coba lapangan melibatkan 349 siswa dan 12 guru SD Mahabodhi Vidya dan SD Muhammadiyah 6. Hasil validasi pakar menunjukkan revisi <em>website</em> sebagai sumber belajar sudah memadai. Asesmen belajar literasi dan numerasi siswa sebagai indikator efektivitas dinilai cukup efektif dengan persentase sebesar 60% pada asesmen literasi dan 56% pada asesmen numerasi. Efektivitas <em>website</em> dari sisi guru sebesar 82% sedangkan dari sisi siswa sebesar 81%. Sedangkan, kepraktisan <em>website</em> sebesar 77% dari sisi siswa dan 79% dari sisi guru. Kepuasan penggunaan <em>website</em> dari sisi guru sebesar 79%. Dapat disimpulkan <em>website</em> <em>Kejarcita</em> pasca revisi dinilai efektif, praktis dan memberikan kepuasan pada pengguna.</p><p class="abstrak"><strong><br /></strong></p><p class="abstrak"><strong><br /></strong></p>
AN ANALYSIS ON LEARNING LOSS AND HOLISTIC EDUCATION
Authors: Zandroto Amel Devina , Indriani Siane 
Published: January 2023

<p><strong>Abstract</strong></p><p>Christian education views students as an image of God. During the pandemic of COVID-19, students encountered learning loss phenomena which has become a challenge for Christian schools. Thus, this study aims to elaborate the difference between Christian perspective and secular perspective toward the “learning loss’ phenomena; how important a holistic education is to be implemented in the classroom; and to explain the role of the teacher as a facilitator to implement holistic learning in the classroom. The research method used in this study is literature review. The result showed that students as the image of God should be valued as a whole person, not only partially as viewed from secular perspectives. Christian teachers need to be equipped to see and teach their students holistically, such as planning their lessons to be ‘contextual’ and relevant for their students in order to raise awareness for tolerance, empower their talents, and conduct learning processes through loving interaction and applying holistic assessments. A recommendation for further research is to implement holistic education at primary level and elaborate the challenges faced by the teacher.</p><p> </p><p><strong>Bahasa Indonesia Abstrak</strong></p><p>Pendidikan Kristen melihat siswa sebagai <em>Image of God</em>. Selama pandemi covid-19 siswa menghadapi satu fenomena, yaitu <em>Learning Loss</em>, di mana terdapat penurunan dalam proses pembelajaran siswa. Oleh karena itu, tujuan dari paper ini adalah untuk menjelaskan perbedaan antara sudut pandang kekristenan dengan sudut pandang sekuler terkait fenomena “<em>learning loss; </em>pentingnya penerapan pendidikan holistis di dalam kelas, dan menjelaskan peran guru sebagai fasilitator dalam mengimplementasikan pendidikan holistis di dalam kelas. Penelitian ini dilakukan menggunakan metode kajian literatur. Hasil penelitian menunjukkan bahwa murid sebagai <em>Image of God </em>seharusnya dididik sebagai manusia yang utuh, dan tidak hanya sebagian seperti halnya dalam pandangan sekuler. Guru Kristen harus diperlengkapi agar dapat melihat dan mengajar secara holistik. Misalnya, merencanakan pembelajaran yang kontekstual dan relevan untuk siswa agar dapat membangkitkan kesadaran mereka akan toleransi dan mengembangkan talenta mereka. Serta mengimplementasikan pendidikan holistik di dalam kelas melalui interaksi yang didasarkan pada kasih serta penerapan penilaian holistik kepada siswa. Sebagai rekomendasi, peneliti menyarankan agar penelitian selanjutnya berfokus pada penerapan pendidikan holistik kepada murid di Sekolah Dasar serta memaparkan tantangan-tantangan yang dihadapi oleh Guru.</p><p> </p><p><strong><br /></strong></p>
Structural Racism, the Social Determination of Health, and Health Inequities: The Intersecting Impacts of Housing and Mass Incarceration
Authors: Blankenship Kim M. , Rosenberg Alana , Schlesinger Penelope , Groves Allison K. , Keene Danya E. 
Published: January 2023

Public health researchers have directed increasing attention to structural racism and its implications for health equity. The conceptualization of racism as historically rooted in systems, structures, and institutions of US society has important implications for addressing social determinants of health (SDOH). It requires theorizing SDOH as embedded in and expressions of racially oppressive historical structures that are manifested in and maintained by policies, programs, and practices in multiple domains that dynamically intersect to reinforce and reproduce in new ways: race inequities in health. We develop this argument using housing, a SDOH recognized as reflecting longstanding racist practices and policies that, among other things, have restricted the affordable housing options of Black people to segregated neighborhoods with limited resources. We argue that understanding and addressing the health inequities resulting from structural racism associated with housing requires simultaneously understanding and addressing how housing intersects with mass incarceration, another SDOH and manifestation of structural racism. We suggest that unless these intersections are intentionally analyzed and confronted, efforts to address the impacts of housing on racial health disparities may produce new forms of health inequities. (Am J Public Health. 2023;113(S1):S58–S64. https://doi.org/10.2105/AJPH.2022.307116 )
Incorporating Structural Racism, Employment Discrimination, and Economic Inequities in the Social Determinants of Health Framework to Understand Agricultural Worker Health Inequities
Authors: Yearby Ruqaiijah , Lewis Crystal , Gibson Charysse 
Published: January 2023

In 2010, the federal government and several state governments began using the social determinants of health (SDOH) framework to highlight contributing factors of health inequities and, in 2022, recognized that structural racism was associated with health inequities. Yet, efforts to eliminate health inequities have disproportionately focused on individualized solutions instead of addressing structural racism. Many racial/ethnic-minority workers have been segregated to low-wage occupations that lack access to paid sick leave, such as agricultural work, which has been associated with health inequities. Research shows these inequities are attributable to structural racism enforced through laws that structure the employment system to disadvantage agricultural workers, who are disproportionately racial/ethnic-minority individuals, which will not be addressed with individualized solutions. In this article, we explain why the current SDOH framework and efforts to eliminate health inequities are inadequate, discuss Yearby’s revised SDOH framework that includes structural racism as one of the root causes of health inequities, and illustrate how Yearby’s revised SDOH framework better captures the impact of structural racism, which is associated with health inequities for agricultural workers. (Am J Public Health. 2023;113(S1):S65–S71. https://doi.org/10.2105/AJPH.2022.307166 )
Sentiment Analysis of OYO App Reviews Using the Support Vector Machine Algorithm
Authors: Zaenal Zaenal , Astutik Ika Ratna Indra 
Published: January 2023

The rapidly growing tourism industry causes the need for hotels to increase. This has led to innovation in the form of virtual hotel operators, one of which is OYO. OYO is a VHO application with the highest rating found on the Google playstore. OYO is one of the applications with millions of users. Of course, this cannot be separated from the ratings and reviews from users. The reviews contained in the playstore itself can contain positive, neutral or even negative opinions. Given the importance of user reviews to application development, this research classifies reviews on the OYO application to determine user sentiment. In this study, the data used is 2,000 data which will be classified into positive, neutral and negative sentiments. The Support vector machine algorithm was chosen because it is capable of producing high accuracy. Based on testing, the Radial basis function kernel is able to produce the highest accuracy among other kernels and by using a dataset division ratio of 80:20 the accuracy obtained is 78.98%. While testing using the Confusion matrix produces an accuracy of 80.36%.
Modeling tuberculosis transmission flow in China
Authors: wang li , Xu Chengdong , Hu Maogui , Wang Jinfeng , Qiao Jiajun , Chen Wei , Zhu Qiankun , Wang Zhipeng 
Published: January 2023

Abstract

Background:
China has the third largest number of TB cases in the world, and the average annual floating population in China is more than 200 million, the increasing floating population across regions has a tremendous potential for spreading infectious diseases, however, the role of increasing massive floating population in tuberculosis transmission is yet unclear in China.
Methods
14,027 tuberculosis flow data were derived from the new smear-positive pulmonary tuberculosis cases in China. Spatial interaction model was used to model the tuberculosis flow and the regional socioeconomic factors.
Results
Tuberculosis transmission flow presented spatial heterogeneity. The Pearl River Delta in southern China and the Yangtze River Delta along China’s east coast presented as the largest destination and concentration areas of tuberculosis inflows. Socioeconomic factors were determinants of tuberculosis flow. Some impact factors showed different spatial associations with tuberculosis transmission flow. A 10% increase in per capita GDP was associated with 2.1% decrease in tuberculosis outflows from the provinces of origin, and 0.5% increase in tuberculosis inflows to the destinations and 18.9% increase in intraprovincial flow. Per capita net income of rural households and per capita disposable income of urban households were positively associated with tuberculosis flows. A 10% increase in per capita net income corresponded to 3.6% increase in outflows from the origin, 12.8% increase in inflows to the destinations and 47.9% increase in intraprovincial flows. Tuberculosis incidence had positive impacts on tuberculosis flows. A 10% increase in the number of tuberculosis cases corresponded to 1.1% increase in tuberculosis inflows to the destinations, 2.0% increase in outflows from the origins, and 2.2% increase in intraprovincial flows.
Conclusions
Tuberculosis flows had clear spatial stratified heterogeneity and spatial autocorrelation, regional socio-economic characteristics had diverse and statistical significant effects on tuberculosis flows in the origin and destination, and income factor played an important role among the determinants.
The Effects of a Single Blood Donation on the Lipid Profile, Iron Storage and Enzymatic Antioxidants
Authors: Kharaz Abdulrhman , Aljohani Abdulaziz , Almalki Abdullah , Alnawajha Mostafa , Alnozha Omar , Aloufi Faisal , Mirza Ahmed A. 
Published: January 2023

AbstractCardiovascular disease (CVD) is a global illness causing 31% of global mortality. Though many factors contribute to CVD, oxidative stress advances atherosclerosis through several complementary components, such as the initiation of lipid peroxidation by iron. Blood donation may decrease the risk of CVD due to reducing the iron level. Literature reported that blood donors have a lower risk of CVD, possibly due to the lower iron levels. Various effects of blood donation are involved in preventing type II diabetes. However, little is known of the exact mechanism of the benefits of blood donation. In this study, samples were collected from 33 healthy male participants pre- (1 day) and post-donation (1 day, 1, 2 and 3 weeks) and the effect of the blood donation on the iron, lipids and enzymatic antioxidants profiles were assessed. A repeated-measures ANOVA was used for comparing the quantitative variables between the visits. We found that the iron decreased significantly by week 1 (–25.3%). Ferritin decreased significantly at weeks 1, 2, and 3 (–26.3%, − 40.3%, − 36.7%, respectively). The superoxide dismutase increased significantly at post-donation day 1, weeks 1, 2, and 3 (17.9%,35.7%, 31.1%, 36.6%, respectively) and in correlation with time [r(165) = 0.50,P < 0 .01]. Glutathione peroxide decreased significantly at week 1 (–25.0%). Glutathione reductase decreased significantly 1-day post donation (–5.7%) then increased over the next three weeks [r(165) = 0.3,P < 0.01]. Finally, the lipids were significantly reduced 24 hours after the donation but not at week 1, 2 and 3. We conclude that blood donation, resulting in a lowered body iron concentration, is an effective way to increase superoxide dismutase and glutathione reductase, which prevent the initiation of lipid oxidation. Our results could be used to advocate for the benefits of blood donation. However, further studies are required to assess the role of blood donation in plaque formation and arteriosclerosis.
Terms used by healthcare professionals to describe opioid use disorder
Authors: Negaard Briana , Kobuzi Helena , Polgreen Linnea 
Published: January 2023

Abstract
Background
Using prescription opioids for a long period of time or at high doses can increase the risk of developing opioid use disorder (OUD). Whether a patient has an official diagnosis of OUD or not can change medical practice regarding how that individual is treated. It is imperative to be aware of who may have an undiagnosed OUD in order to avoid potential negative events such as infectious diseases associated with intravenous drug use. The purpose of this research project is to identify unique words and phrases healthcare professionals commonly use to describe patients with OUD.
Methods
We conducted a retrospective chart review at a tertiary care academic medical center. We included all patients with a diagnosis of OUD who had an encounter with a clinician in 2018. The chart notes from a specific appointment were reviewed to identify any unique terms or phrases used by the healthcare professionals in this note. The unique terms found were reported as a number and rate that represents how many chart notes it appeared in overall.
Results
Overall, 297 encounters in the electronic medical record were analyzed for terms associated with OUD. Of the 297 encounters reviewed, 83 notes had no mention of OUD, and 214 notes were found to have unique terms associated with OUD with a total of 322 unique terms and phrases identified. Opioid use disorder was the most used term occurring in 95 of the 297 (32.0%) encounters. A phrase or term containing the word “opioid” was found in 154 of the 297 (51.9%) notes. Suboxone was the second most common term found in 53 (17.8%) notes. Other common terms included cravings (49, 16.5%), relapse (42, 14.1%), and trigger (26, 8.8%).
Conclusions
OUD often goes undiagnosed. Knowing these key words and searching for them can assist healthcare professionals in identifying patients with undiagnosed OUD.
OPED: an optimal prime editing guide RNA designer based on deep learning and transfer learning
Authors: Shu Wenjie , Liu Feng , Huang Shuhong , Hu Jiongsong , Chen Xiaozhou , Song Ziguo , Dong Junguo , Liu Yao , Huang Xingxu , Wang Xiaolong , Wang Shengqi 
Published: January 2023

Abstract
Prime editors (PEs) are promising genome editing tools, but efficiency pre-testing of prime editing guide RNA (pegRNA) design is still laborious and time-consuming due to the lack of accurate and universal approaches. Here, we design a customized attention-based model OPED and train it using transfer learning to improve the accuracy and universality of efficiency prediction and design optimal pegRNAs. We demonstrate its powerful generalization capability across diverse published test datasets. Furthermore, we extend OPED to design optimal pegRNAs and single guide RNAs (sgRNAs) to install various ClinVar human pathogenic variants, and 28 of 30 (93.33%) target sites yield desired variants with few byproducts and practical editing efficiencies of up to 29.30%, 82.84%, and 90.05% for PE2, PE3/PE3b, and ePE systems, respectively. We construct the OPEDVar database of optimal designs from over two billion candidates for all ClinVar variants and provide a user-friendly web application of OPED for any intended edit.
Functional Somatic Symptoms in Emergency Department Frequent Presenters
Authors: Garde Vidula , Thornton Katherine B. , Pardon Madelyn , Gangathimmaiah Vinay , Mallett Andrew J , Greenslade Jaimi , Watt Kerrianne 
Published: January 2023

Abstract

Background: Patients with Functional Somatic Symptoms (FSS) are frequently encountered within healthcare settings such as Emergency Departments (ED). There is limited research regarding characterisation and frequency of FSS within frequent presenters to ED and no previous Australian evidence. This study aims to fill this gap.
Methods: A retrospective, single-centre study of frequent ED presenters over a 6-month period was undertaken. Patients with >3 re-presentations/month were reviewed for the presence of FSS using Stephenson and Price’s 1 categorisation of FSS. Patients were divided into three groups – FSS, possible FSS (pos-FSS) and non-FSS. The characteristics of these groups were compared using descriptive statistics (chi-square tests, ANOVA). Person-time at risk during the 6-month study period was estimated for patients in each group and incidence of ED presentation for each group was then calculated. Psychological distress indicators for ED presenters with FSS, as noted by the treating clinician, were also analysed.
Results: 11% (71/638) of frequent ED presenters were categorised as having FSS and 17% (109/638) as having possible FSS (pos-FSS). Mean ED presentations in the FSS group during the study period were significantly higher than in the non-FSS and pos-FSS groups (p<.01). Anxiety was found to be the primary psychological distress indicator associated with ED presentations with FSS.
Conclusion: We found that, amongst frequent ED presenters, patients with FSS presented significantly more frequently to ED than those without FSS. We propose revising the model of care for FSS in ED to promote appropriate referral to therapy services as a possible demand reduction strategy to improve patient care and efficiency in ED.
Reprogramming the Human Gut Microbiome Reduces Dietary Energy Harvest
Authors: Smith Steven , Corbin Karen , Carnero Elvis , Dirks Blake , Igudesman Daria , Yi Fanchao , Marcus Andrew , Davis Taylor , Pratley Richard , Rittmann Bruce , Krajmalnik-Brown Rosa 
Published: January 2023

Abstract
The gut microbiome is emerging as a key modulator of host energy balance1. We conducted a quantitative bioenergetics study aimed at understanding microbial and host factors contributing to energy balance. We used a Microbiome Enhancer Diet (MBD) to reprogram the gut microbiome by delivering more dietary substrates to the colon and randomized healthy participants into a within-subject crossover study with a Western Diet (WD) as a comparator. In a metabolic ward where the environment was strictly controlled, we measured energy intake, energy expenditure, and energy output (fecal, urinary, and methane)2. The primary endpoint was the within-participant difference in host metabolizable energy between experimental conditions. The MBD led to an additional 116 ± 56 kcals lost in feces daily and thus, lower metabolizable energy for the host by channeling more energy to the colon and microbes. The MBD drove significant shifts in microbial biomass, community structure, and fermentation, with parallel alterations to the host enteroendocrine system and without altering appetite or energy expenditure. Host metabolizable energy on the MBD had quantitatively significant interindividual variability, which was associated with differences in the composition of the gut microbiota experimentally and colonic transit time and short-chain fatty acid absorption in silico. Our results provide key insights into how a diet designed to optimize the gut microbiome lowers host metabolizable energy in healthy humans.