bluuebunny/crossref_metadata_2025_split huggingface dataset:
Separatist Agitations in Nigeria: A Critical Analysis of National Integration Under Buhari Administration
Authors: Udeh Celestine O. , Edeh Herbert C. , Obiagu Uchenna C. , Madu Chidi P. , Agwu Stanley C. 
Published: March 2023

Abstract
This study examined the interface between separatist agitations and national integration under Buhari’s Administration in Nigeria. The study investigated the various separatist groups operating in Nigeria, particularly the Indigenous People of Biafra (IPOB) that emerged as an outcome of unbearable incidence of marginalisation by Buhari’s administration. The study leveraged on the propositional trappings of relative deprivation theory to explain and bear witness to the argument that when marginalization consistently goes beyond its bearable height against groups to favour others, it would amount to relative deprivation. This becomes a breeding ground for various forms of agitation like self-determination. The study relied on documentary method for data gathering and adopted content analysis for analysing the materials generated. It firmly upheld that marginalisation, as obviously witnessed in Buhari-led administration, not only resulted in the revitalisation of the various separatist groups, but also undermined national integration in Nigeria. It recommended, amongst other things, for an inclusive national policy of integration and unity.
From Insurgent to Petitioner: Representational Shifts in Subaltern Resistance in the Late Nineteenth-Century French Colonial Context
Authors: Lauwers Karen 
Published: March 2023

Abstract
The first part of this essay addresses what a microhistory of petitions has to offer to subaltern studies. The second part illustrates this with a late nineteenth-century case-study revolving around a Kabyle man formerly belonging to the intermediate sphere between French-colonial and local Algerian society. Concretely, the focus lies on Ahmed ben Ali ben Aouadi and the political knowledge to which his 1888-petition to the French Chamber of Deputies and its chairman testified. This written interaction must be seen as an attempt to challenge the institutional framing of his family’s subaltern identity and to reclaim their property, confiscated by the French state. The third section of this essay reveals an interactive exchange between this colonial subject’s subaltern resistance and the institutional counter-resistance of the French colonizer’s legislative and executive authorities, which extended far beyond Aouadi’s second petition in 1892, and thus challenges our notions of political agency and success.
Diurnal Cycle Dependence of ENSO Influence on the Winter Surface Air Temperature in Southeastern China
Authors: Geng Xin , Noh Kyung-Min , Kug Jong-Seong , Zhang Wenjun 
Published: March 2023

Abstract
It is well known that El Niño–Southern Oscillation (ENSO) can influence the East Asian winter climate by modifying the atmospheric circulation over the western North Pacific (WNP). While the impact on precipitation in southeastern China has been extensively studied, the ENSO signal in surface air temperature (SAT) remains overlooked. In this paper, we identify robust ENSO footprints in the winter daily minimum SAT in southeastern China, with El Niño winters generally accompanied by warmer-than-normal minimum SAT anomalies. In contrast, the responses of maximum SAT are weak and negligible, suggesting a diurnal cycle–dependent ENSO influence. Further analysis indicates that this diurnal cycle dependence stems primarily from the disparate surface radiative heating between day and night induced by ENSO-related local total cloud cover (TCC) change. The warmer minimum SAT occurring in the early morning of El Niño winters is mainly caused by the enhanced surface downward longwave radiative heating as a result of the TCC increase. However, in the afternoon of El Niño winters, although the anomalous horizontal advection of warm air plays a role, there is surface radiative cooling as the weakening of solar radiation due to TCC reflection overwhelms the increase in downward longwave radiation, which leads to a weakened sensible heat flux and thus has a cooling effect on the SAT. Ultimately, these two processes effectively cancel each other out and together produce insignificant maximum SAT responses. Our conclusions carry important implications for the seasonal to interannual winter climate prediction in southeastern China.

Significance Statement
The purpose of this study is to better understand how ENSO influences winter surface air temperature in southeastern China. Despite insignificant responses of winter daily maximum temperature to ENSO, we find here a robust ENSO influence on the daily minimum temperature, with warm anomalies tending to occur during El Niño events. Further evidence suggests that this diurnal cycle–dependent ENSO influence is mainly caused by ENSO-induced change in local cloudiness, which has a different radiative heating effect between day and night. Our findings are of great importance for improving regional climate prediction, which will benefit social and economic activities.
Carpal Tunnel Anthropometrics Using Acrylic Casts: A Cadaveric Study With Implications for Carpal Tunnel Release
Authors: Carmo José D. , Cardoso Rui C. , Silva Helder V. , Jesus Rui F. 
Published: March 2023

Background: Abundant literature exists on the morphology of the carpal tunnel. Despite this, the shape of the carpal tunnel has been reported erratically, and most studies did not attempt to correlate findings with measurements taken from cadavers. The objective of this study was to perform a morphological analysis, determine the shape and mean dimensions of the carpal tunnel, determine the level of the narrowest area of the tunnel, and establish a set of values capable of serving as a reference for carpal tunnel release. Methods: The carpal tunnels of 20 fresh cadaveric hands were dissected, and acrylic casts were created and measured using industrial computed tomography. Results: Of the 20 casts, 19 were shaped like elliptic cylinders, with little variation in their measurements along the length. The location of the narrowest section of the carpal tunnel is very different among casts, and the length of the roof of the carpal tunnel ranged from 21.26 to 29.86 mm. Conclusions: The most common shape of the carpal tunnel is an elliptic cylinder. Because of the unpredictability of the location of the narrowest area of the carpal tunnel, carpal tunnel release must continue through all extension of its roof. We advise that the release should rarely be extended distally more than 30 mm from the distal palmar wrist crease, which corresponds, in most cases, to the middle of the pisiform.
Characteristics of rib fracture patients who require chest computed tomography in the emergency department
Authors: Kim Woosik , Song Juhyun , Moon Sungwoo , Kim Jooyeong , Cho Hanjin , Park Jonghak , Kim Sungjin , Ahn Sejoong 
Published: March 2023

Abstract
Background
The disadvantages and complications of computed tomography (CT) can be minimized if CT is performed in rib fracture patients with high probability of intra-thoracic and intra-abdominal injuries and CT is omitted in rib fracture patients with low probability of intra-thoracic and intra-abdominal injuries. This study aimed to evaluate the factors that can identify patients with rib fractures with intra-thoracic and intra-abdominal injuries in the emergency department among patients with rib fracture.

Methods
This retrospective observational study included adult patients (age ≥ 18 years) diagnosed with rib fracture on chest radiography prior to chest CT due to blunt chest trauma in the emergency department who underwent chest CT from January 2016 to February 2021. The primary outcomes were intra-thoracic and intra-abdominal injuries that could be identified on a chest CT. Multivariate logistic regression analysis was performed.

Results
Among the characteristics of rib fractures, the number of rib fractures was greater (5.0 [3.0–7.0] vs. 2.0 [1.0–3.0], p < 0.001), bilateral rib fractures were frequent (56 [20.1%] vs. 12 [9.8%], p = 0.018), and lateral and posterior rib fracture was more frequent (lateral rib fracture: 160 [57.3%] vs. 25 [20.5%], p < 0.001; posterior rib fracture: 129 [46.2%] vs. 21 [17.2%], p < 0.001), and displacement was more frequent (99 [35.5%] vs. 6 [6.6%], p < 0.001) in the group with intra-thoracic and intra-abdominal injuries than in the group with no injury. The number of rib fractures (adjusted odds ratio [aOR], 1.44; 95% confidence interval [CI], 1.16–1.78; p = 0.001), lateral rib fracture (aOR, 2.80; 95% CI, 1.32–5.95; p = 0.008), and posterior rib fracture (aOR, 3.18; 95% CI, 1.45–6.94; p = 0.004) were independently associated with intra-thoracic and intra-abdominal injuries. The optimal cut-off for the number of rib fractures on the outcome was three. The number of rib fractures ≥ 3 (aOR, 3.01; 95% CI, 1.35–6.71; p = 0.007) was independently associated with intra-thoracic and intra-abdominal injuries.

Conclusion
In patients with rib fractures due to blunt trauma, those with lateral or posterior rib fractures, those with ≥ 3 rib fractures, and those requiring O2 supplementation require chest CT to identify significant intra-thoracic and intra-abdominal injuries in the emergency department.
The efficacy and safety of temperature controlled dual-mode radiofrequency in women with vaginal laxity
Authors: FU Lixia , Long Senyang , LI Qin , XU Hainan , Guo Ling , Wang Huarong , Zheng Zhongyan , Zhang Jing 
Published: March 2023

Abstract
Objective
Vaginal laxity could negatively influence women’s sexual function. This study aimed to explore the efficacy and safety of temperature controlled dual-mode (monopolar and bipolar) radiofrequency (RF) in women with vaginal laxity.

Methods
A total of 102 patients with vaginal laxity were treated with temperature-controlled RF. The present study implemented Vaginal Laxity Questionnaire (VLQ), Female Sexual Function Index (FSFI) questionnaire and Sexual Satisfaction Questionnaire (SSQ) on all patients at baseline and after treatment. Pelvic Organ Prolapse Quantification System (POP-Q) system was applied to physical examination, and vaginal manometer to examine the strength of voluntary contractions of the pelvic floor muscles.

Results
The VLQ score was gradually increased after RF treatment at 1, 3, 6 and 12 months, accompanying by the significant improvement in total FSFI scores and the six domains (sexual desire, sexual arousal, lubrication, orgasm, satisfaction, pain). The increased sexual satisfaction based on the SSQ score was found after temperature-controlled RF. The result of POP-Q stage showed significant difference in women after treatment, with the women having Stage I of 45.10% at baseline, 36.27% at 1 month, 28.43% at 3 months, 19.61% at 6 months and 10.78% at 12 months. The mean pressure and mean duration of pelvic contractions were increased gradually at the 1-, 3-, 6- and 12- month follow-up.

Conclusion
Temperature controlled dual-mode (monopolar and bipolar) radiofrequency may be associated with improvement of vaginal laxity, and contribute to enhancement to female sexual function and pelvic floor muscles.
Use of health services one year before primary colorectal cancer
Authors: Hermiö Elina , Seppä Karri , Ryynänen Heidi , Hirvonen Elli , Pylkkänen Liisa , Järvelin Jutta , Malila Nea , Pitkäniemi Janne 
Published: March 2023

Abstract
Background
Colorectal cancer (CRC) patient pathways focus typically on periods after confirmed diagnosis and only limited data are available on pathways prior to cancer diagnosis. The aim of the study was to describe the use of health services (HS) one year before diagnosis among CRC patients in Finland. We also studied the role of sex, age, stage, and university hospital district in relation to the use of HS during the pre-diagnostic phase. This information is expected to bring light on the question why CRC is often not found in its early stages.

Methods
Incident CRC cases (N = 3115) concerning year 2015 were retrieved from the Finnish Cancer Registry and linked with data from the Finnish Institute for Health and Welfare on primary or specialised care outpatient visits or inpatient episodes over one year prior to CRC diagnosis. We modelled the average number of HS events per patient using Poisson regression model with log-link. Change points for monthly HS event rates and 95% CIs one year before diagnosis were evaluated using Poisson broken line regression models.

Results
Around 10% of patients diagnosed in 2015 had no events prior to cancer leaving 2816 CRCs in the study. Of all pre-diagnostic events (N = 23268), 86% were outpatient events and 14% inpatient episodes. More than half of the inpatient episodes (65%) started as urgent admissions. The use of HS started to increase 3–4 months before diagnosis. The average number of pre-diagnostic HS events per patient varied by sex, age, stage and university hospital district. Overall, men had more events per patient than women and older patients had more events than younger patients.

Conclusions
The amount of inpatient episodes starting as urgent admissions indicate potential bottlenecks in the access to health services. An increase in service use only 3–4 months prior to diagnosis reflects a need for advice both for health care professionals and the general population in recognising symptoms of CRC.
Ultrasound-guided phlebotomy in primary care for people who inject drugs
Authors: Huyck Michael , Mayer Stockton , Messmer Sarah , Yingling Charles , Stephenson Shirley 
Published: March 2023

Abstract
Objectives
Persons who inject drugs (PWID) commonly experience venous degradation as a complication of prolonged injection, which makes routine phlebotomy difficult. Clients may decline care due to the perceived lack of skilled phlebotomy services, and this contributes to significant delays in infectious disease screening and treatment. In this study, we investigated ultrasound-guided phlebotomy in clients with difficult venous access receiving care at two low-threshold buprenorphine clinics. Our objectives were to increase the accuracy of vascular access, expedite infectious disease treatment for hepatitis C virus (HCV) and human immunodeficiency virus (HIV), and increase client satisfaction with phlebotomy services.

Methods
PWID who declined routine phlebotomy at two clinic sites were offered ultrasound-guided vascular access by a trained clinician. Participants completed a survey to collect data regarding acceptability of the intervention.

Results
Throughout a 14-month period, 17 participants were enrolled. Of the total 30 procedures, 41.2% of clients returned for more than one phlebotomy visit, and 88.2% of clients achieved vascular access within 1 attempt. Of participating clients, 52.9% described themselves as having difficult venous access and at conclusion of the study, 58.8% expressed more willingness to have phlebotomy performed with an ultrasound device.

Conclusions
Offering ultrasound-guided phlebotomy for PWID with difficult venous access resulted in decreased access attempts, increased patient satisfaction, and expedited screening and treatment for HIV and HCV point-of-care ultrasound technology is an effective approach to improving care for persons who inject drugs.
The healing effects of thymoquinone on experimentally induced traumatic tendinopathy in rabbits
Authors: Soltanfar Alireza , Meimandi Parizi Abdolhamid , Foad-Noorbakhsh Mohammad , Sayyari Mansour , Iraji Aida 
Published: March 2023

Abstract
Objectives
Thymoquinone is a major bioactive compound present in the black seeds of the Nigella sativa. Tendon injuries are almost 50% of all musculoskeletal injuries. The recovery of tendon after surgery has become a significant challenge in orthopedics.

Design
The purpose of this study was to investigate the healing effect of thymoquinone injections in 40 New Zealand rabbits tendon traumatic models.

Materials and methods
Tendinopathy was induced by trauma using surgical forceps on the Achilles tendon. Animals were randomly divided into 4 groups: (1) normal saline injection (control), (2) DMSO injection, (3) thymoquinone 5% w/w injection, and (4) thymoquinone 10% w/w injection. Forty-two days after surgery, biochemical and histopathological evaluations were done, and biomechanical evaluation was conducted 70 days after surgery.

Results
Breakpoint and yield points in treatment groups were significantly higher compared to control and DMSO groups. Hydroxyproline content in the 10% thymoquinone receiving group was higher than all groups. Edema and hemorrhage in the histopathological evaluation were significantly lower in the thymoquinone 10% and thymoquinone 5% receiving groups compared to control and DMSO groups. Collagen fibers, collagen fibers with fibrocytes, and collagen fibers with fibroblasts were significantly higher in the thymoquinone 10% and thymoquinone 5% receiving groups compared to control groups.

Conclusions
Thymoquinone injection in the tendon in the concentration of 10% w/w is a simple and low-cost healing agent that could enhance mechanical and collagen synthesis in traumatic tendinopathy models in rabbit.
Trajectories of child mental health, physical activity and screen-time during the COVID-19 pandemic considering different family situations: results from a longitudinal birth cohort
Authors: Kurz Deborah , Braig Stefanie , Genuneit Jon , Rothenbacher Dietrich 
Published: March 2023

Abstract
Background
Many authors have described a significant mental health burden on children and adolescents during the COVID-19 pandemic, possibly moderated by social disparities. This analysis explores whether pre-pandemic family circumstances might be related to different aspects of child health during the pandemic.

Methods
We analyzed trajectories of health-related outcomes in children aged 5 to 9 years (T7 to T11) using the Ulm SPATZ Health study, a population based birth cohort study (baseline 04/2012–05/2013) conducted in the South of Germany. Outcomes were children’s mental health, quality of life, and lifestyle, such as screen time and physical activity. We conducted descriptive statistics of maternal and child characteristics before and throughout the pandemic. We defined three different groups of pre-pandemic family situations and used adjusted mixed models to estimate differences in means associated with the time during the pandemic vs. before the pandemic in (a) all children and in (b) children belonging to specific pre-pandemic family situations.

Results
We analyzed data from n = 588 children from whom at least one questionnaire was completed between T7 and T11. When not considering the pre-pandemic family situation, adjusted mixed models showed statistically significant lower mean scores of health-related quality of life among girls during vs. before the COVID-19 pandemic (difference in means (b): − 3.9 (95% confidence interval (CI): − 6.4, − 1.4). There were no substantial differences in mental health, screen time, or physical activity in boys or girls. When considering pre-pandemic family situations, boys with mothers having symptoms of depression or anxiety showed a substantial loss of health-related quality of life on the subscale of friends (b: − 10.5 (95% CI: − 19.7, − 1.4)). Among girls in this group, 60% of the 15 assessed outcomes were negatively associated with a remarkable loss in health-related quality of life (e.g., KINDL-physical well-being difference in means: − 12.2 (95% CI: − 18.9, − 5.4)). Furthermore, a substantial increase in screen time was found (+ 2.9 h (95% CI: 0.3, 5.6)).

Conclusion
Our results suggest that the health (and behavior) of primary school-aged children is possibly impacted by the COVID-19 pandemic, with adverse consequences differing by gender and very likely by the pre-pandemic family situation. Especially in girls having a mother with depression or anxiety symptoms, the adverse consequences of the pandemic on mental health seem to be aggregated. Boys showed fewer adverse trajectories, and it needs to be further assessed which factors exactly are behind the (socio-economic) factors, such as maternal working habits and limited living space, when analyzing the effect of the pandemic on children’s health.
Evidence for the role of transcription factors in the co-transcriptional regulation of intron retention
Authors: Ullah Fahad , Jabeen Saira , Salton Maayan , Reddy Anireddy S. N. , Ben-Hur Asa 
Published: March 2023

Abstract
Background
Alternative splicing is a widespread regulatory phenomenon that enables a single gene to produce multiple transcripts. Among the different types of alternative splicing, intron retention is one of the least explored despite its high prevalence in both plants and animals. The recent discovery that the majority of splicing is co-transcriptional has led to the finding that chromatin state affects alternative splicing. Therefore, it is plausible that transcription factors can regulate splicing outcomes.

Results
We provide evidence for the hypothesis that transcription factors are involved in the regulation of intron retention by studying regions of open chromatin in retained and excised introns. Using deep learning models designed to distinguish between regions of open chromatin in retained introns and non-retained introns, we identified motifs enriched in IR events with significant hits to known human transcription factors. Our model predicts that the majority of transcription factors that affect intron retention come from the zinc finger family. We demonstrate the validity of these predictions using ChIP-seq data for multiple zinc finger transcription factors and find strong over-representation for their peaks in intron retention events.

Conclusions
This work opens up opportunities for further studies that elucidate the mechanisms by which transcription factors affect intron retention and other forms of splicing.

Availability
Source code available at https://github.com/fahadahaf/chromir