bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telomere-to-telomere gap-free genome assembly and chromosome segment substitution lines facilitated gene identification in wild rice
Authors: Huang Jingfen , Zhang Yilin , Li Yapeng , Xing Meng , Wang Shizhuang , Lei Cailin , Nie Yamin , Wang Yanyan , Zhao Mingchao , Han Zhenyun , Sun Xianjun , Han Zhou , Zheng Xiaoming , Xiao Xiaorong , Fan Weiya , Liu Ziran , Guo Wenlong , Zhang Lifang , Cheng Yunlian , Qian Qian , He Hang , yang qingwen , Qiao Weihua 
Published: February 2023

Abstract

The abounding variations hidden in wild rice (Oryza rufipogon) provided potential reservoirs of useful genes for rice breeding. However, the genome of wild rice has not yet been comprehensively assessed. In this study, we constructed the telomere-to-telomere (T2T) genome assembly and annotation of wild rice Y476 with a total length of 421.1 Mb and 38,055 predicted protein-coding genes, which features evident improvements in the continuity and quality of sequence compared with the existing wild rice genomes. Of Y476 genome assembly, 128 Mb and 5,984 novel genes were not found in ‘Nipponbare’ reference, leading to 690 gene families expanded and 247 gene families contracted, including disease resistance and grain regulation gene family. Two sets of chromosome segments substitution lines (CSSLs) were constructed, using Y476 as the donor parent and cultivated rice as the recurrent parents, covering the whole genome of Y476, providing materials for introducing novel genes and identification of their function. Combining the T2T reference genome and CSSL population, 254 QTLs associated with agronomic traits, biotic and abiotic stresses were identified. A receptor-like kinase gene associated with rice blast resistance was identified, a 7.8-kb insertion was found in the intron of this gene which increased its expression level. Using CRISPR/Cas9 technology and transcriptomic data, we confirmed that this wild rice allele improves rice blast resistance via regulating OsMADS26 expression. Collectively, our findings provided not only a T2T gap-free reference genome but also a highly efficient platform for novel gene identification of O. rufipogon, and therefore, have important implications for wild rice utilization.
Assessing association of dental caries with child oral impact on daily performance using directed acyclic graphs; a cross-sectional study of adolescents in Copperbelt province, Zambia
Authors: Anthony Severine N , Kahabuka Febronia K , Birungi Nancy , Åstrøm Anne N , Siziya Seter , Mbawalla Hawa S 
Published: February 2023

Abstract
Purpose

To assess the association between dental caries and Child Oral Impact on Daily Performance (C-OIDP). Secondarily, the study evaluated psychometric properties, prevalence, and factors associated with C-OIDP.

Methods

A cross-sectional study was conducted among adolescents in Copperbelt province, Zambia. Socio-demographics, oral health behaviors, self-reported oral health, and C-OIDP were assessed using a self-administered questionnaire. Dental caries was assessed according to Caries Assessment & Treatment Spectrum (CAST). A directed acyclic graph (DAG) was used to determine a minimum set of covariates for the adjusted analysis. Data analysis was done using Stata/SE (version 17).

Results

Among 1,794 participants, 54.0% were females, while 56.0% were aged 11–14 years. Prevalence of self-reported poor teeth health, clinically assessed dental caries and, C-OIDP were 18.3%, 46.2% and 31.5%, respectively. The highest prevalence of oral impacts were with eating (26.5%), cleaning teeth (16.4%), and sleeping (12.5%). Child -OIDP Spearman's correlations of the items ranged from 0.399 to 0.641. The participants with dental caries were 2.6 times (AOR 2.6, 95% CI 2.1, 3.2) more likely to report oral impacts than those without caries. Consuming a sugary diet five times or more per day increased the odds of C-OIDP by 1.5 times (AOR 1.5, 95% CI 1.2, 1.9) while, dental visits in the past year decreased the odds of C-OIDP by 30% (AOR 0.7, 95% CI 0.6, 0.9).

Conclusions

The English version of C-OIDP is a reliable index for assessing OHRQoL among Zambian adolescents. Prevalence of C-OIDP was high, and problems with eating, cleaning teeth, and sleeping were the most frequently reported items. Dental caries was associated with increased C-OIDP. Covariates selected based on DAGs showed consuming a sugary diet more than five times per day increased the odds of C-OIDP, while dental visits at least once per year decreased the likelihood of reporting C-OIDP.
WITHDRAWN: Coffee and Caffeine Consumption and Risk of Periodontitis: NHANES 2009 to 2014
Authors: Guo Xu-Guang , Liao Wan-Zhe , Zhou Zhi-Yi , Zhu Xiao-Feng , Xie Shuo-Jia , Lin Zi-Kai , Wu Xian-Nan , Li Song-An , Chen Hao-Kai , Chen Zhi-Feng , Xu Zhe , Li Ya-Han , Zhang Zhi-Yuan 
Published: February 2023

Abstract
Objectives
In this study, assessing whether coffee consumption and caffeine intake were associated with periodontitis infection separately was set as the objective.
Materials and Methods
Divided into binary and continuous categories, coffee consumption was set as the exposure variable along with caffeine intake and periodontitis infection as the outcome variables. Other covariables were regarded as potential confounders. The cross-sectional study was conducted based on the National Health and Nutrition Examination Survey, with multivariate regression models, subgroup analyses, smooth fitting curves, and threshold effect examinations conducted to pursue a definite correlation between exposures and the outcome.
Results
Negative associations were discovered between binary coffee consumption and caffeine intake and periodontitis infection, with all confounders adjusted. In subgroup analyses stratified by sex, diabetes mellitus status, and hypertension status, interaction and threshold effects were observed, which were revealed intuitively by smooth-fitting curves.
Conclusions
Significant negative associations between binary consumption and caffeine intake and periodontitis infection separately were indicated, with no evidence suggesting a credible correlation between continuous coffee consumption and periodontitis infection risk. The benefits of the behavior of consuming coffee and consuming caffeine were more obvious among males and individuals who do not suffer from diabetes or hypertension.
Secondary gains of strategies to prevent COVID 19 infection in neonatal intensive care unit: has the frequency of healthcare-associated infections decreased?
Authors: Bülbül Ali , Avşar Hasan , Baş Evrim Kıray , Atar Gülsün 
Published: February 2023

Abstract
Purpose
We aimed to compare the frequency and distribution of healthcare associated infections (HAI) in the neonatal intensive care unit at two different times (during pre-COVID-19 period and during COVID-19 period). Our hypothesis as infection control measures taken due to COVID-19 infection have a positive effect on reducing the frequency of HAIs in the neonatal intensive care unit.
Method
Our study was conducted between March - September 2019 (pre-COVID-19 period) and March - September 2020 (during COVID-19 period). All cases with HAIs were included. Demographic characteristics, interventional procedures, feeding style, morbidity and mortality and infection foci were recorded in the case follow-up form. The data obtained in the two periods were compared.
Results
During the determined study period, 427 babies in the pre-COVID-19 period and 530 babies in the COVID-19 period were evaluated. HAIs were determined in 47 patients (60 attack) and 39 patients (44 attack) in the pre-COVID-19 period and during the COVID-19 period, respectively. HAIs incidence density were found 5.43 in pre-COVID-19 period and 4.87 in COVID-19 period. During the COVID-19 period, there was a significant decrease in the healthcare-associated infection incidence density, hospital-associated infection rate and bloodstream infection (p:0.009). No statistical difference was found in catheter-related infection rate (p:0.35) and ventilator associated pneomonia rate (p:0.19).
Conclusions
It has been determined that COVID-19 infection prevention strategies reduce the frequency of healthcare associated infection especially in bloodstream infection in neonatal intensive care units.
Emerging Trends and Research Foci of Deep Learning in Spine: Bibliometric and Visualization Study
Authors: Chen Kai , Zhai Xiao , Wang Sheng , Li Xiaoyu , Lu Zhikai , Xia Demeng , Li Ming 
Published: February 2023

Abstract
As the cognition of spine develops, deep learning (DL) presents a tremendous potential and function as an advantageous tool in this field. In this study, bibliometrics and visual methods were adopted with a retrieval of Web of Science to provide a comprehensive overview of DL-spine research. VOSviewer and Citespace were primarily used for literature measurement and knowledge graph analysis. A total of 273 studies was retrieved focusing on DL in spine with a sum of 2407 citations, and the global total number of articles published showed a continuous increasing trend. China was the country with the largest number of publications, while USA was the country with the most citation. The top 2 journals were “European spine journal” and “Medical image analysis”, and the most involved research area was Radiology Nuclear Medicine Medical Imaging. VOSviewer visually presented three clusters into “segmentation”, “area”, and “neural network”. And CiteSpace indicated the keywords with the longest use were “magnetic resonance image” and “lumbar”, while “agreement” and “automated detection” were the most popular keywords. The stage of DL-spine research is still in its infancy and its future is bright. Intercontinental cooperation, extensive application and more interpretable algorithms will exert more vitality in this field.
Can digital economy be a “new engine” for urban green economy development? An empirical analysis of Chinese cities
Authors: Zhao Junfeng , Yan Jinling 
Published: February 2023

Abstract

Digitization and greening are the vital driving force of China’s economic transformation. Whether they can drive collaboratively China’s economy is the key to realizing sustainable development. In this study, a super efficiency EBM model is applied to calculate the urban green economy development (UGED) level of 266 Chinese cities between 2011 and 2020, and then the dynamic SDM and intermediary effect models are employed to explore the impact and transmission mechanism of digital economy on UGED. Furthermore, it is also investigated whether digital economy and UGED have a nonlinear relationship. In the findings, digital economy is capable of significantly boosting UGED in the local city and its neighborhood, but significant differences exist in different regions and economic development stages. As a result of the transmission mechanism test, it may be found that digital economy could indirectly boost UGED through technology, structure, and allocation effects. The impact of digital economy on UGED has a double threshold due to the significant difference in the urban economic development level. The digital economy is increasingly contributing to UGED as the local economy develops. Therefore, local governments should develop digital economy in line with the local conditions so that its engine role in driving UGED can be given full play.
The impact of gut bacteria producing long chain homologs of vitamin K₂ on colorectal carcinogenesis
Authors: Smajdor Joanna , Jedlińska Katarzyna , Porada Radosław , Górska Anna , Policht Aleksandra , Śróttek Małgorzata , Więcek Grażyna , Baś Bogusław , Strus Magdalena 
Published: February 2023

Abstract
Colorectal cancer (CRC) is one of the foremost causes of cancer-related deaths. Lately, a close connection between the course of CRC and the intestinal microbiota has been revealed. Vitamin K₂ (VK₂) is a bacterially derived compound that plays a crucial role in the human body. Its significant anti-cancer properties may result, inter alia, from a quinone ring possessing a specific chemical structure found in many chemotherapeutics. VK₂ can be supplied to our body exogenously, i.e., through dietary supplements or fermented food (e.g., yellow cheese, fermented soybeans -Natto), and endogenously, i.e., through the production of bacteria that constantly colonize the human microbiome of the large intestine. This paper focuses on endogenous K₂ synthesized by the most active members of the human gut microbiome. This analysis tested 86 intestinally derived bacterial strains, among which the largest VK₂ producers (Lactobacillus, Bifidobacterium, Bacillus) were selected. Moreover, based on the chosen VK₂-MK4 homolog, the potential of VK₂ penetration into Caco-2 cells in an aqueous environment without the coexistence of fats, pancreatic enzymes, or bile salts has been displayed. Moreover, the unique role of long-chain homologs (VK2-MK9 and VK2-MK7) in inhibiting the secretion of pro-inflammatory cytokines such as IL-8 (for Caco-2 tissue) and IL-6 and TNFα (for RAW 264.7) has been documented.
Motivational interviewing from the pediatricians' perspective: assessments after a 2-day training for physicians caring for adolescents with chronic medical conditions (CMCs)
Authors: Kammering Hannah , Cruz Jennifer Antony , Platzbecker Anna Lena , Reinauer Christina , Viermann Rabea , Domhardt Matthias , Baumeister Harald , Förtsch Katharina , Krassuki Lisa , Staab Doris , Minden Kirsten , Mueller-Stierlin Annabel Sandra , Holl Reinhard W. , Warschburger Petra , Meissner Thomas 
Published: February 2023

Abstract
Background: Counseling adolescents with chronic medical conditions (CMCs) can be challenging regarding suitable interviewing skills and clinicians' attitudes toward the patient. Successful communication can be a key element of treatment. Motivational Interviewing (MI) is broadly applicable in managing behavioural problems and diseases by increasing patient motivation for lifestyle changes. However, data concerning the applicability, feasibility, and implementation of MI sessions in everyday practice are missing from the physicians' point of view.
Purpose: Our aim was to explore clinicians' experiences of MI training and subsequent use of MI in the routine care of adolescents with CMCs. Therefore, we wanted to find out if and how MI can be integrated into clinical practice and how training in MI should be designed.
Method:The present study has a descriptive and qualitative design. Twenty pediatricians were randomized to a 2-day MI course followed by MI consultations in a cluster-randomized controlled trial (COACH-MI). Data were collected one year after MI training using a questionnaire. Factors for effective training and possible barriers to successful use of MI were examined.
Results: Completed questionnaires were returned by 19 of 20 pediatricians. The pediatricians' experiences with MI demonstrate that MI is regarded as a valuable tool when working with adolescents with CMCs. 95 % of all respondents reported that they found MI education necessary for their clinical work and were using it also outside the COACH-MI study context. 73.7 % percent saw potential to strengthen the connection to their patients by using MI. The doctors were already using more MI conversation techniques after a 2-day MI course. Obstacles were seen in the short training, the lack of time, and missing undisturbed environment (interruptions by telephone, staff, etc.) during clinical flow.
Conclusions: MI techniques are not yet a regular part of medical training. However, a 2-day MI course was rated effective and providing a lasting impact by physicians caring for children and adolescents with chronic medical conditions (CMCs), although booster sessions should be offered regularly.
On the possibility of measuring solar flattening from photometry measurements taken during solar eclipses seen from the Earth’s Surface or Earth Orbit
Authors: Wang Yunbo , Yan Jianguo , Barriot Jean-Pierre 
Published: February 2023

Abstract
Solar oblateness is a key parameter that provides a strong constraint for understanding the variations in total solar irradiance as well as the differential rotation of the Sun. Furthermore, it takes part in the evaluation of General Relativity theory. In this paper, we propose a procedure to measure solar flattening based on modeling the light curve during a solar eclipse observed from the ground or from the Earth orbit. We apply this procedure to the solar eclipse observed from Lakeland (Queensland, North Australia) on November 13, 2012. The results show that accurate measurements of the solar equator-to-polar radius difference can reach 1 km when based on the current DE430 ephemeris and the LRO DEM data (equivalent to 1.4 10− 6 in solar oblateness).
Holographic entanglement entropy for Kerr-Neuman black hole in asymptotically flat space-time
Authors: taibi hamza 
Published: February 2023

Abstract
We compute the Holographic Entanglement entropy for Kerr-Neuman
black hole in asymptotically flat space-time. We consider a boundary
placed either far away from the horizon or very close to the event horizon.
In the first case, we find that angular momentum contribution
does not appear until the second order in the perturbative expansion
which is negligibly small. A version of the first law of entanglement
entropy is verified in this case. For the boundary near the horizon, we
found that entropy increases with increasing angular momentum and
it reaches it ’s maximum value in the extremal limit.
Operator frame for HomA*(X)
Authors: Eljazzar Roumaissae , Rossafi Mohamed , Paokanta Siriluk , Park Choonkil 
Published: February 2023

Abstract
The concept of operator frame can be considered as a generalization of frame. Firstly, we introduce the notion of operator frame for the set of all adjointable operators Hom∗A(X ) on a Hilbert pro-C∗ -module X . The analysis operator, the synthesis operator and the frame operator are presented. Secondly, we study the stability of operator frame under small perturbations. We also study the tensor product of operator frame for Hilbert pro-C∗ -modules. Finally, we establish its dual and some properties.
AMS Subject Classification: Primary 42C15; 46L05
Investigating the impact of eugenol on the suppression of gallic acid oxidation by employing cyclic voltammetry
Authors: Roy Aindrila , Das Chirantan , Chowdhury Basudev Nag , Bhattacharya Debopam , Karmakar Anupam , Chattopadhyay Sanatan 
Published: February 2023

Abstract

Gallic Acid (GA), naturally resourced in fruits, spices and several leafy vegetables including tea leaves, is a promising antioxidant, dietary supplement and therapeutic agent. However, it gets oxidized spontaneously in ambient condition causing oxidative damages to DNA and proteins. The current work sought to investigate the effect of Eugenol (Eug) on suppressing such oxidation of GA by employing Cyclic Voltammetry (CV) technique. Voltammetric analysis indicates a significant suppression of such oxidation process with increasing a small amount of Eug concentration (~ 0.1–0.4 v/v %). In the present study, platinum (Pt) working electrode has been considered instead of conventional glassy carbon electrode (GCE) due to its superior sensitivity towards GA solution. Such voltammetric results have been further investigated by absorption spectroscopy and FTIR measurements. The absorption spectrum exhibits a prominent peak due to GA at 265 nm, which is observed to diminish continuously with the addition of Eug. Further, the FT-IR spectroscopic measurements show the appearance of a characteristic ‘C-O stretching’ peak at 1021 cm− 1on addition of Eug suggesting the possible formation of phenolic ether. The method has been extended to quantify the amount of GA content in a solution and examined by applying on an aqueous solution of arbitrary amount of GA, green tea and black tea, which are observed to agree satisfactorily with reported values. The entire study also suggests the controlled utilization of Eug in solutions containing GA to suppress its oxidation process thereby improving the health benefits of tea and other such bioconsumables.
Some new integral inequalities for s-convex functions of exponential type
Authors:   1-Attazar Bakht, Anwar Matloob 
Published: February 2023

Abstract

In this paper, we propose and analyze the concept of s-convex function ofexponential type, as well as some of its algebraic properties are discussed. Inaddition, for the newly suggested class of functions, we demonstrate several newintegral inequalities of the Hermite-Hadamard (H-H) type. Furthermore, weexplore various variants of the H-H type inequalities for a function whose firstabsolute derivative at a certain power is s-convex function of exponential type. Inaccordance with this newly proposed concept, we studied various applications ofspecial means. We hope that the technique studied in this work will further sparkthe interest of interested scholars.
AMS Subject Classification: Primary 26D15; secondary 26A51
Associations between R.E.N.A.L nephrometry score and survival outcomes in renal tumors
Authors: Zhang Xue , Lin Jinglai , Qi Yangyang , Xiong Ying , Qi Yu , Xi Wei , Li Xiaoxia , Miao Chongchang , Quan Xiaolin , Sun Qi 
Published: February 2023

Abstract
Objective
R.E.N.A.L. nephrometry score could be used to predict surgical outcomes and renal tumor aggressiveness. We aimed to analyze its associations with survival outcomes.
Materials and methods
We included 1368 patients with sporadic, unilateral and non-metastatic renal tumors who received curative nephrectomy in Zhongshan Hospital from January 2009 to September 2019. R.E.N.A.L. nephrometry scores (RNS) were assigned by three urologists based on preoperative CT/MRI scans. Correlations between parameters or sum of RNS, overall survival (OS) and recurrence-free survival (RFS) were analyzed by Kaplan-Meier analyses and multivariate cox regression model. We further compared survival outcomes between patients who received partial nephrectomy and patients who received radical nephrectomy.
Results
We observed statistically significant associations between all components of RNS and oncologic outcomes, including R (Radius) (OS, p < 0.001; RFS, p < 0.001), E (Exophytic/endophytic) (OS, p = 0.003; RFS, p < 0.001), N (Nearness) (OS, p = 0.063; RFS, p < 0.001), A (Anterior/posterior) (OS, p < 0.001; RFS, p = 0.005), L (Location) (OS, P = 0.008; RFS, p < 0.001) and suffix “h” (OS, p = 0.237; RFS, p = 0.034). Kaplan-Meier curves of OS and RFS rates were significantly different when stratified by RNS complexity group (OS, p < 0.001; RFS, p < 0.001). After adjusting for tumor stage and grade, RNS as continuous variables was an adverse independent risk factor for survival outcomes [p = 0.027, HR (95%CI) = 1.151 (1.016–1.303)] and RFS [p < 0.001, HR(95%CI) = 1.299 (1.125–1.501)]. For tumors with RNS score of 4 and 5, partial nephrectomy showed a survival benefit than radical nephrectomy.
Conclusion
Both components and complexity groups of R.E.N.A.L. nephrometry score associated with survival outcomes in renal tumor patients.