bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facial attractiveness is only weakly linked to genome–wide heterozygosity
Authors: Fieder Martin , Huber Susanne 
Published: April 2023

IntroductionIt has been frequently suggested that overall genomic heterozygosity and, particularly, heterozygosity of loci on the so-called major histocompatibility complex (MHC), which is responsible for the recognition of foreign substances/ pathogens and the recognition of self and non-self, is associated with better health and better resistance to infections and parasites. It has further been speculated that such a potentially beneficial heterozygosity can be detected through body odor and facial attractiveness.MethodsOn the basis of genome wide SNP data (713,014 SNPs) of participants from the Wisconsin Longitudinal Study, we therefore investigated whether homozygosity either on the MHC (measured as inbreeding coefficient) or genome-wide (measured as runs of homozygosity and inbreeding coefficient) is associated with rated facial attractiveness.ResultsAlthough we found that the genome-wide average length of homozygous segments and the genome-wide inbreeding coefficient are significantly negatively associated with some measures of facial attractiveness, if corrected for multiple testing, any significant association was no longer formally significant after correction. In addition, the variance in facial attractiveness explained by the genome wide homozygosity is very low (&lt;0.15%). We did not find any significant association between the inbreeding coefficient on the MHC and facial attractiveness.DiscussionWe only find a weak association of genome- wide heterozygosity and facial attractiveness.
Association between apathy in patients with maintenance dialysis and hospitalization or mortality: a prospective cohort study
Authors: Fang Yu , Chen Lei , Zhang Yueyue , Yuan Weijie , Han Bin 
Published: April 2023

BackgroundPatients receiving maintenance dialysis experience increased rates of hospitalization and mortality. Apathy is associated with reduced quality of life and increased hospitalization, institutionalization, and death. Whether apathy contributes to poor outcomes in population undergoing maintenance dialysis remain unknown.MethodsWe conducted a prospective cohort study of maintenance dialysis population who were consecutively recruited at the Dialysis Center of Shanghai General Hospital between July 2017 and August 2018 and were followed up for 3 year. Apathy status was measured by the Apathy Evaluation Scale. The study outcomes were the occurrence of death and first hospitalization.ResultsA total of 647 participants included in this study, 274 (42.3%) had a current apathy and 373 (57.7%) were not. During the follow-up period, 394 (60.9%) were hospitalized, and 169 (26.1%) died. Kaplan–Meier analysis showed that the risks of hospitalization and mortality were significantly higher in individuals with apathy than in those without apathy (both p &lt; 0.001). Apathy at baseline was associated with hospitalization and death both in univariate analysis and in all multivariable models (all p &lt; 0.001).ConclusionApathy was highly prevalent and independently correlated with an increased risk of poor outcomes in patients with maintenance dialysis.
Barriers to opioid use disorder treatment: A comparison of self-reported information from social media with barriers found in literature
Authors: Bremer Whitney , Plaisance Karma , Walker Drew , Bonn Matthew , Love Jennifer S. , Perrone Jeanmarie , Sarker Abeed 
Published: April 2023

IntroductionMedications such as buprenorphine and methadone are effective for treating opioid use disorder (OUD), but many patients face barriers related to treatment and access. We analyzed two sources of data—social media and published literature—to categorize and quantify such barriers.MethodsIn this mixed methods study, we analyzed social media (Reddit) posts from three OUD-related forums (subreddits): r/suboxone, r/Methadone, and r/naltrexone. We applied natural language processing to identify posts relevant to treatment barriers, categorized them into insurance- and non-insurance-related, and manually subcategorized them into fine-grained topics. For comparison, we used substance use-, OUD- and barrier-related keywords to identify relevant articles from PubMed published between 2006 and 2022. We searched publications for language expressing fear of barriers, and hesitation or disinterest in medication treatment because of barriers, paying particular attention to the affected population groups described.ResultsOn social media, the top three insurance-related barriers included having no insurance (22.5%), insurance not covering OUD treatment (24.7%), and general difficulties of using insurance for OUD treatment (38.2%); while the top two non-insurance-related barriers included stigma (47.6%), and financial difficulties (26.2%). For published literature, stigma was the most prominently reported barrier, occurring in 78.9% of the publications reviewed, followed by financial and/or logistical issues to receiving medication treatment (73.7%), gender-specific barriers (36.8%), and fear (31.5%).ConclusionThe stigma associated with OUD and/or seeking treatment and insurance/cost are the two most common types of barriers reported in the two sources combined. Harm reduction efforts addressing barriers to recovery may benefit from leveraging multiple data sources.
Combination of everolimus and low-dose tacrolimus controls histological liver allograft injury as sufficiently as high-dose tacrolimus
Authors: Bosselmann Emily A. , Dranicki Fabian , Campos-Murguia Alejandro , Hartleben Björn , Wedemeyer Heiner , Jaeckel Elmar , Taubert Richard 
Published: April 2023

IntroductionThe combination of everolimus (EVR) and low-dose tacrolimus (lowTAC) prevents T cell-mediated rejection of liver grafts as sufficiently as high-dose tacrolimus (highTAC) and mycophenolate, but is associated with a preserved kidney function within the first years after orthotopic liver transplantation (OLT). However, none of the available studies assessed the histological pattern of graft injury or fibrosis in surveillance biopsies (svLbx).MethodsAll svLbx taken under at least one month of stable immunosuppression with either EVR (aim 3-8 ng/ml) combined with lowTAC (aim 3-5 ng/ml) or highTAC (aim 5-8 ng/ml) combined with mycophenolate (500-1500 mg/day) within the first three to four years after OLT at our center were included. Patients who were switched to EVR because of insufficient control of alloreactivity were excluded.ResultsReasons for switches to EVR were mainly malignancies before or after OLT, or chronic kidney injury. We were able to include 20 svLbx with EVR/lowTAC and 49 with highTAC/mycophenolate. Both groups had similar liver enzymes and similar kidney function. The EVR/lowTAC group exhibited lower TAC trough levels at svLbx (4.4 vs. 6.6 ng/ml; p&lt;.001) in comparison to highTAC/mycophenolate. Histological graft injury quantified by the rejection activity index and hepatitis activity index (Ishak), as well as fibrosis were not significantly different between the EVR/lowTAC and highTAC/mycophenolate groups. Likewise, subclinical TCMR, histological criteria justifying immunosuppression minimization, and steatosis had equal prevalence in both regimens. Immunosuppression was adjusted according to the svLbx findings. Immunosuppression regimens had similarly low rates of rejection after immunosuppression reduction, when relevant graft injury was absent in the biopsy.DiscussionIn conclusion, EVR/lowTAC seems to control alloreactivity and histological graft injury as sufficiently as highTAC/mycophenolate within the first 3-4 years after OLT.
Resection of cervical extra-intraspinal neuromas through the enlarged intervertebral foramen: Results in 34 case series patients
Authors: Chang Chuan , Che Xiao-Ming , Zhang Ming-Guang 
Published: April 2023

ObjectiveThe purpose of this study was to analyze the techniques used to resection cervical extra-intraspinal neuromas (also known as cervical dumbbell neuromas) through the enlarged intervertebral foramen.MethodsA total of 34 consecutive patients (19 male, 15 female) with cervical dumbbell neuromas reviewed retrospectively between April 2008 and May 2020. Sixteen tumors were found in the intervertebral foramen of C1-C3, four in C3-C4, and 14 in C4-T1. The approach in all cases was to expose the tumors by intermuscular dissection and to remove them through the enlarged intervertebral foramen without excision of any bony structures. However, to expose tumors at different locations, the incisions shall be made accordingly. In this case series, the incisions were made along the posterior border of the sternocleidomastoid muscle for the C1-C3 tumors and along the anterior border of the muscle for the C3-C4 tumors. Transverse incisions were required for the C4-T1 tumors.ResultsFollowing the mentioned incising approach, all 34 tumors were completely exposed. 31 were completely removed in one stage, and 3 tumors underwent subtotal resection because of brachial plexus nerve adhesion. The vertebral artery and spinal cord were undamaged for all cases. The patients who had total tumor resection showed no sign of recurrence on enhanced magnetic resonance imaging during follow-ups. The status of patients who underwent subtotal resection was stable after radiation therapy. None of the patients developed spinal instability.ConclusionsCervical dumbbell neuromas can be exposed and removed through the enlarged intervertebral foramen without causing spinal instability or injury to the spinal cord or vertebral artery. This operative approach can retain the integrity of the structures of spine and should be considered the ideal approach for cervical dumbbell neuromas.
Properties of Convex Fuzzy-Number-Valued Functions on Harmonic Convex Set in the Second Sense and Related Inequalities via Up and Down Fuzzy Relation
Authors: Khan Muhammad Bilal , Stević Željko , Maash Abdulwadoud A. , Noor Muhammad Aslam , Soliman Mohamed S. 
Published: April 2023

In this paper, we provide different variants of the Hermite–Hadamard (H⋅H) inequality using the concept of a new class of convex mappings, which is referred to as up and down harmonically s-convex fuzzy-number-valued functions (UDH s-convex FNVM) in the second sense based on the up and down fuzzy inclusion relation. The findings are confirmed with certain numerical calculations that take a few appropriate examples into account. The results deal with various integrals of the 2ρσρ+σ type and are innovative in the setting of up and down harmonically s-convex fuzzy-number-valued functions. Moreover, we acquire classical and new exceptional cases that can be seen as applications of our main outcomes. In our opinion, this will make a significant contribution to encouraging more research.
The Salt Tolerance–Related Protein (STRP) Is a Positive Regulator of the Response to Salt Stress in Arabidopsis thaliana
Authors: Fiorillo Anna , Manai Michela , Visconti Sabina , Camoni Lorenzo 
Published: April 2023

Salt stress is a major abiotic stress limiting plant survival and crop productivity. Plant adaptation to salt stress involves complex responses, including changes in gene expression, regulation of hormone signaling, and production of stress-responsive proteins. The Salt Tolerance–Related Protein (STRP) has been recently characterized as a Late Embryogenesis Abundant (LEA)–like, intrinsically disordered protein involved in plant responses to cold stress. In addition, STRP has been proposed as a mediator of salt stress response in Arabidopsis thaliana, but its role has still to be fully clarified. Here, we investigated the role of STRP in salt stress responses in A. thaliana. The protein rapidly accumulates under salt stress due to a reduction of proteasome–mediated degradation. Physiological and biochemical responses of the strp mutant and STRP–overexpressing (STRP OE) plants demonstrate that salt stress impairs seed germination and seedling development more markedly in the strp mutant than in A. thaliana wild type (wt). At the same time, the inhibitory effect is significantly reduced in STRP OE plants. Moreover, the strp mutant has a lower ability to counteract oxidative stress, cannot accumulate the osmocompatible solute proline, and does not increase abscisic acid (ABA) levels in response to salinity stress. Accordingly, the opposite effect was observed in STRP OE plants. Overall, obtained results suggest that STRP performs its protective functions by reducing the oxidative burst induced by salt stress, and plays a role in the osmotic adjustment mechanisms required to preserve cellular homeostasis. These findings propose STRP as a critical component of the response mechanisms to saline stress in A. thaliana.
Aplicación del arte dramático en el desarrollo de la identidad y autonomía en niños de educación inicial
Authors: Solórzano María Karina , Zambrano Loor Tania Miladi 
Published: April 2023

La presente investigación tuvo como objetivo, analizar la aplicación del arte dramático y su incidencia en el desarrollo de la identidad y autonomía en niños de educación inicial del Cantón Chone; El trabajo se ejecutó bajo un enfoque cuali-cuantitativo, fue de tipo exploratoria y bibliográfico. La información teórica se fundamentó mediante los métodos analítico-sintético, inductivo-deductivo. Para la recolección de datos se acudió a las técnicas de encuesta y entrevista aplicadas a docentes de educación inicial y un experto en el área, obteniendo bases estadísticas con resultados porcentuales de la información recopilada. Los resultados obtenidos indican que los docentes tienen conocimientos del tema de estudio e implementan actividades y técnicas teatrales en las aulas. Se concluye que, es vital aplicar el arte dramático en la educación inicial para desarrollar la identidad-autonomía en niños y niñas de 3 a 5 años, puesto que aporta en la formación integral, estimulando las esferas de la creatividad, imaginación, sensibilidad, espontaneidad y otras formas de expresión; el niño encuentra satisfacción emocional permitiéndole relacionarse con sus pares, aprendiendo a trabajar de manera cooperativa, desarrollando todas sus habilidades motoras, sociales y emocionales, evidenciando cambios positivos al momento de enfrentar al mundo de manera independiente y segura
PALABRAS CLAVE: Arte dramático; identidad y autonomía; formación integral; formas de expresión.
Application of dramatic art in the development of identity and autonomy in early childhood children
The objective of this research was to analyze the application of dramatic art and its incidence in the development of identity and autonomy in children of initial education in Chone city; The work was carried out under a qualitative-quantitative approach, it was a kind of exploratory and bibliographic. The theoretical information was based on analytical-synthetic, inductive-deductive methods. For data collection, survey and interview techniques applied to early childhood teachers and an expert in the area, getting statistical bases with percentage results of the information collected. The results obtained indicate that teachers have knowledge of the subject of study and implement theatrical activities and techniques in the classrooms. It is concluded that it is vital to apply dramatic art in initial education to develop identity and autonomy in boys and girls from 3 to 5 years old, since it contributes to comprehensive training, stimulating the spheres of creativity, imagination, sensitivity, spontaneity and other forms of expression; The child finds emotional satisfaction allowing him to interact with his peers, learning to work cooperatively, developing all his motor, social and emotional skills, showing positive changes when facing the world independently and safely.
KEYWORDS: Dramatic art; identity and autonomy; integral formation; forms of expression.
Desarrollo de habilidades comunicativas en estudiantes con discapacidad intelectual
Authors: Bravo Zambrano Génices Narcisa , Enríquez Caro Lázaro Clodoaldo 
Published: April 2023

El trabajo aborda el desarrollo de las habilidades comunicativas de estudiantes con Discapacidad Intelectual (DI) que asisten a la Unidad Educativa Especializada María Buitrón de Zumárraga de la ciudad de Portoviejo, Manabí, Ecuador. Se realizó una estudio mixto de corte transversal descriptivo, con el propósito de identificar cuáles son las necesidades comunicativas que presentan actualmente los participantes, la muestra estuvo integrada por 20 escolares con DI del nivel medio de educación. Se aplicó un instrumento “ad hoc” con una consistencia interna evaluada con Alfa de Cronbach = 0,87. Entre los principales resultados se estableció que los estudiantes manifestaron inicialmente un bajo nivel de habilidades comunicativa, el confinamiento ocasionado por el Covid-19, afectó aún más su comunicación, al solo interactuar con otros en el contexto docente a través de una pantalla, al concluir el aislamiento ellos se vinculan poco en las actividades realizadas por profesores por lo que aún se les dificultan la interacción con otras personas ajenas a su círculo familiar, esto genera la necesidad de intervenir en el desarrollo de sus habilidades comunicativas
PALABRAS CLAVES: Discapacidad Intelectual; habilidades comunicativas; comunicación.
Development of communication skills in students with intellectual disabilities
ABSTRACT
The work addresses the development of the communicative skills of students with Intellectual Disability (ID) who attend the María Buitrón de Zumárraga Specialized Educational Unit in the city of Portoviejo, Manabí, Ecuador. A mixed descriptive cross-sectional study was carried out, with the purpose of identifying what are the communicative needs that the participants currently present, the sample was composed of 20 schoolchildren with ID of the middle level of education. An "ad hoc" instrument was applied with an internal consistency evaluated with Cronbach's Alpha = 0.87. Among the main results it was established that the students initially manifested a low level of communicative skills, the confinement caused by Covid-19, further affected their communication, by only interacting with others in the teaching context through a screen, at the end of the isolation they are little linked in the activities carried out by teachers, this generates the need to intervene in the development of their communication skills
KEYWORDS: Intellectual disability; communication skills; communication.
Improvement of analytical determination of cyproconazole and propiconazole in fruit crops
Authors: Panchenko T. , Cherviakova L. 
Published: April 2023

Goal. Development and unification of the method of simultaneous determination of cyproconazole and propiconazole in fruits (apples, peaches, grapes) by gas-liquid chromatography (GC).
Methods. The active substances were determined by gas-liquid chromatography (GC) using a gas chromatograph «Perkin Elmer 8410» with an NPD detector. Propiconazole and cyproconazole were identified by the retention time of the compounds, quantification by the calibration dependence of the chromatographic peak area of the analyte on its concentration in the calibration solution by correlation and regression analyzes.
Results. The choice of the method of determination is limited by the physicochemical properties of the active substance and the characteristics of the object under study (matrix). The optimal conditions for determination were selected using a chemical-analytical monitoring algorithm and a system for multiquantitative determination of pesticides in matrices. According to them, the matrices are analyzed in stages: extraction, purification, qualitative and quantitative determination. Cyproconazole and propiconazole are low-polar compounds (µ of their cis- and trans-isomers are 4.43; 4.71 and 3.80; 4.20 D, respectively), so extraction was performed with chloroform (ε 5.1). Purification of extracts from coextractive substances of matrices was performed by TLC. Compounds were identified by retention time, and quantification (C, µg/ml) was performed on the areas of chromatographic peaks (S, mm2) in the range of linear detection (2—10 ng) according to the linear regression equations: Sc = 11.991 C — 6.096 (R2 = 0.998); Sp = 13.721 C – 4.221 (R2 = 0,994). The average value of measurement is 81.0—87.8%; standard deviation 2.21—5.38%; confidence interval (P 0.95; n = 15) 1.94—4.72%.
Conclusions. Optimal selective conditions for the analysis of triazole derivatives by chromatographic methods provide simultaneous determination of test compounds and quality control of fruit crops on the content of residual amounts of cyproconazole and propiconazole at the level of hygienic standards (MAL 0.05—0.10 mg/kg).
Supernova Dust Evolution Probed by Deep-sea 60Fe Time History
Authors: Ertel Adrienne F. , Fry Brian J. , Fields Brian D. , Ellis John 
Published: April 2023

Abstract
There is a wealth of data on live, undecayed 60Fe (t
1/2 = 2.6 Myr) in deep-sea deposits, the lunar regolith, cosmic rays, and Antarctic snow, which is interpreted as originating from the recent explosions of at least two near-Earth supernovae. We use the 60Fe profiles in deep-sea sediments to estimate the timescale of supernova debris deposition beginning ∼3 Myr ago. The available data admits a variety of different profile functions, but in all cases the best-fit 60Fe pulse durations are >1.6 Myr when all the data is combined. This timescale far exceeds the ≲0.1 Myr pulse that would be expected if 60Fe was entrained in the supernova blast wave plasma. We interpret the long signal duration as evidence that 60Fe arrives in the form of supernova dust, whose dynamics are separate from but coupled to the evolution of the blast plasma. In this framework, the >1.6 Myr is that for dust stopping due to drag forces. This scenario is consistent with the simulations in Fry et al. (2020), where the dust is magnetically trapped in supernova remnants and thereby confined around regions of the remnant dominated by supernova ejects, where magnetic fields are low. This picture fits naturally with models of cosmic-ray injection of refractory elements as sputtered supernova dust grains and implies that the recent 60Fe detections in cosmic rays complement the fragments of grains that survived to arrive on the Earth and Moon. Finally, we present possible tests for this scenario.
Action Cœur de Ville : la proximité pour développer durablement nos territoires
Authors: Mouchel-Blaisot Rollon 
Published: April 2023

Pendant cinq décennies, on a trouvé pertinent d’éloigner de plus en plus nos concitoyens des emplois, commerces, services et activités. Ce modèle urbain isolant les habitants, vidant nos beaux cœurs de ville et détruisant nos espaces naturels, agricoles et forestiers a implosé, car insoutenable économiquement, écologiquement et socialement. C’est en réaction à cette vision mortifère que le programme national Action cœur de ville a été imaginé en 2017, afin de soutenir les villes dites moyennes en redynamisant leur cœur de ville, en stoppant l’étalement urbain et en ré-imaginant une ville plus attractive, naturelle et inclusive, pour tous. Le caractère transversal d’Action Cœur de Ville, politique prioritaire du gouvernement quasiment coconstruite avec les destinataires, vise à répondre au mieux aux projets des collectivités portés par les maires, au plus proche des préoccupations et envies des habitants et des acteurs locaux. Ainsi, ce programme national, s’appuyant sur des collectivités dynamiques formant un réseau territorial unique en Europe, est pleinement mobilisée sur les défis des trois grandes transitions de notre temps : écologique, économique et démographique. C’est dans et avec les territoires que les solutions pourront être trouvées.