bluuebunny/crossref_metadata_2025_split huggingface dataset:
An ARFID case report assessment with 18F-FDG PET/MRI and treatment with olanzapine, escitalopram and fluoxetine in adult
Authors: Liu Meichen , Chang Yiheng , Xie Xueting , Liu Yudan , Tian Shiyun , Yang Chun , Zhao Ziqi , Zhang Huimin 
Published: January 2025

BackgroundAvoidant/restrictive food intake disorder (ARFID), a DSM-5-introduced eating disorder, is increasingly prevalent and challenging to treat, primarily affecting children and adolescents, with limited adult case reports. This rarity in adults leads to misdiagnosis or underdiagnosis, and treatment experiences are scarce.Case presentationThis report details an adult ARFID case, where the patient’s fear of food intake followed gastric damage from corn ingestion, resulting in a restrictive diet of rice porridge due to gastric pain. The behavior is driven by fear of eating-related adverse effects.ResultBased on clinical symptoms assessment, semi-structured interviews, and comprehensive testing, including PET/MRI scans to exclude secondary conditions, a diagnosis of ARFID was confirmed. ARFID, a newly introduced diagnosis in the DSM-5, is uncommon in adults with sparse case data. Differentiating it from gastrointestinal diseases and other psychiatric conditions is crucial for precise diagnosis and focused treatment.ConclusionIn this paper, we report on the clinical diagnosis, imaging manifestations, treatment, and follow-up of an adult ARFID case, highlighting the utility of neuroimaging in diagnosis and differentiation. It also assesses the therapeutic efficacy of olanzapine, escitalopram oxalate, and fluoxetine hydrobromide, offering clinical guidance for diagnosing and managing ARFID.
The progress in the field of clinical staging for mental disorders within the last decade: an updated systematic review
Authors: Clarke Sharon L. , Soons Nicole , Videler Arjan C. , van Alphen Sebastiaan P. J. , Van Henricus , Dil Linda , Pappijn Laurens , Corbeij Sven , Broekhof Beau , Chanen Andrew M. , Hutsebaut Joost 
Published: January 2025

IntroductionClinical staging aims to refine psychiatric diagnosis by describing mental disorders on a continuum of disorder progression, with the pragmatic goal of improved treatment planning and outcome prediction. The first systematic review on this topic, published a decade ago, included 78 papers, and identified separate staging models for schizophrenia, unipolar depression, bipolar disorder, panic disorder, substance use disorder, anorexia, and bulimia nervosa. The current review updates this review by including new proposals for staging models and by systematically reviewing research based upon full or partial staging models since 2012.MethodsPsycINFO, MEDLINE, EMBASE, and the Cochrane databases were systematically searched from 2012 to June 2023. The original review’s eligibility criteria were used and extended with newly introduced categories of DSM-5 mental disorders, along with mental disorders for which a progressive course might be expected. Included papers: a) contained a complete or partial staging model, or b) focused upon clinical features that might be associated with stages, or c) focused upon treatment research associated with specific stages.ResultsSeventy-one publications met the inclusion criteria. They described staging models for schizophrenia and related psychoses (21 papers), bipolar (20), depressive (4), anxiety (2), obsessive-compulsive (3), trauma related (4), eating (3), personality disorders (2), and ‘transdiagnostic’ staging models (13).DiscussionThere is a steady but slow increase in interest in clinical staging and evidence for the validity of staging remains scarce. Staging models might need to be better tailored to the complexities of mental disorders to improve their clinical utility.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021291703.
Assessing and projecting the global impacts of Alzheimer’s disease
Authors: Zhang Nanlong , Chai Shuren , Wang Jixing 
Published: January 2025

BackgroundThis study aims to assess the global burden of Alzheimer’s disease (AD) from 1990 to 2030, with a focus on incidence, mortality, and disability-adjusted life years (DALY).MethodsData on the incidence rates, DALY rates, and death rates of AD across various geographic populations from 1990 to 2021 were obtained from the Global Burden of Disease (GBD) 2021 study. Generalized Additive Models (GAMs) were employed to forecast the disease burden from 2022 to 2030.ResultsThe projected global burden of Alzheimer’s disease from 2022 to 2030 indicates a decrease in DALYs, with an Estimated Annual Percentage Change (EAPC) of −1.44 (95% CI: −1.45, −1.42). Similarly, death rates and incidence rates also show a decline, with EAPCs of −1.80 (95% CI: −1.83, −1.77) and −1.27 (95% CI: −1.29, −1.26) respectively. Gender-specific analysis reveals that the projected global incidence EAPC from 2022 to 2030 is estimated at −1.73 (95% CI: −1.75, −1.70) for males and −1.03 (95% CI: −1.04, −1.02) for females. Regionally, Andean Latin America and the Caribbean exhibit the highest positive EAPCs for DALYs at 0.94 (95% CI: 0.93, 0.94) and 0.59 (95% CI: 0.59, 0.60) respectively, while Eastern Europe shows the lowest EAPC at −16.31 (95% CI: −18.60, −13.95). Country-specific projections highlight Cyprus and Serbia with the highest positive EAPCs for DALYs at 12.55 (95% CI: 11.21, 13.91) and 9.6416 (95% CI: 8.86, 10.4333) respectively. On the other hand, Bahrain and Armenia exhibit significant negative EAPCs at −87.28 (95% CI: −94.66, −69.70) and −85.41 (95% CI: −92.80, −70.41). An analysis based on the Socio-Demographic Index (SDI) reveals that regions with higher SDI values have greater burdens of AD, with countries having SDI ≥ 0.8 showing significantly higher age-standardized Incidence Rates (ASIR), age-standardized Death Rates (ASDR), and age-standardized DALY rates compared to those with SDI &lt; 0.8.ConclusionFrom 1990 to 2030, global burden of AD is projected to decrease, with significant gender and regional disparities. Regions with higher SDI show higher disease burdens, underscoring the necessity for targeted interventions and customized public health strategies to effectively address AD in varied socio-economic settings.
Management of rare and undiagnosed diseases: insights from researchers and healthcare professionals in Türkiye
Authors: Durmus Sinem , Yucesan Emrah , Aktug Sinem , Utz Begum , Caglayan Ahmet Okay , Gencpinar Pinar , Günay Cagatay , Oktay Yavuz , Yildirim Ravza Nur , Yigit Ayca , Ozbek Ugur 
Published: January 2025

IntroductionDiagnosis, treatment and management of rare diseases (RD) pose unique challenges due to their complex nature, significantly impacting the daily experiences of researchers and healthcare professionals working in this field. Despite increasing awareness and progress in the field of RD worldwide in recent years, a significant gap remains in our understanding of the specific barriers that these professionals face in their work with RD. This study provides a detailed survey analysis that sheds light on the challenges that researchers and healthcare professionals face in diagnosing, treating, managing and conducting research on RD.MethodsWe developed a national online survey with three RD stakeholder groups (Researchers, Healthcare professionals and researcher-healthcare professionals) to identify the main challenges and needs in Türkiye for the diagnosis, treatment and follow-up processes of rare and undiagnosed diseases.ResultsThe survey was completed by 363 participants, revealing that participants face key challenges such as the need to refer patients to specialized centers, financial burdens, limited access to necessary tests, inadequate support for rare disease research and a lack of interdisciplinary collaboration. Participants also noted that RD are inherently difficult to conduct research on with small cohorts. Survey results also suggest a number of policy improvements to accelerate research on RD: increased funding, establishment of robust surveillance systems, and development of comprehensive national action plans and guidelines on RD.DiscussionTo the best of our knowledge, this is the first study to be conducted in Türkiye. This study contributes to the understanding of the needs of professionals in rare disease research and highlights the urgent need for system improvements to support them.
Transferencia de conocimiento en la práctica docente de educación inicial, Colombia
Authors: Cera-Torrenegra Lilibeth Lorena 
Published: January 2025

El objetivo general de la investigación fue analizar la transferencia de conocimiento en la práctica docente de educación inicial, Colombia.El estudio se realizó desde la perspectiva cuantitativa, mediante la recuperación, recopilación y análisis crítico de referencias documentales y bibliográficas. En este sentido, desde un diseño bibliográfico de tipo documental, los investigadores realizaron un proceso investigativo en donde la población de estudio se fundamentó básicamente en documentos escritos como trabajos arbitrados, convenios, entre otros. Además, se emplearon los métodos analíticos–sintético e inductivo-deductivo. Se concluye que, dentro del contexto de Educación inicial de la enseñanza superior del municipio Maicao, departamento de la Guajira, Colombia, es muy factible que los mecanismos de transferencia de conocimiento, tales como en serie, cercana, lejana, estratégica y experta, pudieran plantearse de manera efectiva, considerando que los docentes pueden ser capaces de utilizar el conocimiento de otros para la consecución de los objetivos institucionales.
Обзор достижений водоподготовки в области деферризации и деманганации подземных вод
Authors: Пропольский Д.Э. 
Published: January 2025

Для обеспечения населения питьевой водой необходимо, чтобы качество очищенной воды соответствовало требованиям стандартов. Отсутствие надлежащего источника водоснабжения либо использование питьевой воды с превышением значений предельно допустимых концентраций загрязняющих веществ впоследствии наносят вред здоровью человека. Кроме того, возникает ухудшение работы систем водоснабжения в результате образования коррозии, отложений и закупорки труб. Одной из существенных проблем при водоподготовке подземных вод является повышенная концентрация железа (Fe) и марганца (Mn). Описаны существующие методы обезжелезивания и деманганации воды, условия их применения. Кроме того, проведен сравнительный анализ методов и рассмотрены перспективные направления в данной области. Установлено, что все существующие способы удаления железа и марганца имеют либо требуют этапа фильтрации. Использование в фильтрах каталитического слоя из модифицированных загрузок позволяет достичь более высоких показателей очистки и фильтрации, что обеспечит снижение затрат станций водоподготовки и стоимость очищенной подземной воды.
To provide the population with drinking water, it is necessary that the quality of purified water meets the standard requirements. The absence of an appropriate water supply source or the use of drinking water with exceeding the maximum permissible concentrations of pollutants subsequently harms human health. Besides, a deterioration in the operation of water supply systems occurs as a result of corrosion, deposits and blockage of pipes. One of the major problems of groundwater treatment is the increased concentration of iron (Fe) and manganese (Mn). The existing methods of iron and manganese removal from water and the conditions of their application are described. In addition, a comparative analysis of the methods is carried out and promising areas in this area are considered. It has been established that all the existing methods of iron and manganese removal either have or require a filtration stage. The use of a catalytic layer of modified media in filters provides for achieving higher purification and filtration rates that will reduce the expenditures of water treatment plants and the cost of purified underground water.
Perancangan Aplikasi Digital Trash Management Berbasis Website Menggunakan Metode Waterfall
Authors: Wijaya Dhina 
Published: January 2025

Abstract — The waste management in Kalurahan Guwosari is still facing significant challenges, with a system that is implemented in a modular fashion and lacks innovation, resulting in suboptimal utilization of residues. Every day, this region generates around 2.5 tons of waste, most of which is not properly managed, leading to accumulation at temporary disposal sites and environmental pollution risks. To improve this situation, the Kalurahan government has developed a web-based digital waste management application as an innovative solution. This application is unique because it not only offers real-time reporting and monitoring of waste but also includes interactive features that encourage active community participation, differing from other solutions that are often one-way. Utilizing the Waterfall method for development, the application has been tested using black box methods, yielding positive feedback from approximately 85% of users who feel the application is effective and has increased waste condition reporting by 60% compared to previous methods. It is hoped that this application will enhance community involvement in waste management, contribute to improving environmental quality, reduce the volume of unmanaged waste, and increase local awareness and income through waste reuse and recycling.

Key words— waste management, web-based application, waterfall method

Abstrak — Tata kelola sampah di Kalurahan Guwosari masih menghadapi tantangan besar, dengan sistem yang dilakukan secara modular dan minim inovasi, sehingga menyebabkan pemanfaatan residu yang tidak optimal. Setiap harinya, Kalurahan ini menghasilkan sekitar 2,5 ton sampah, yang sebagian besar tidak terkelola dengan baik, mengakibatkan penumpukan di tempat pembuangan sementara dan risiko pencemaran lingkungan. Untuk meningkatkan situasi ini, pemerintah Kalurahan Guwosari mengembangkan aplikasi digital manajemen sampah berbasis web sebagai solusi inovatif. Aplikasi ini unik karena tidak hanya menawarkan pelaporan dan pemantauan sampah secara real-time, tetapi juga fitur-fitur interaktif yang mendorong partisipasi aktif masyarakat, berbeda dengan solusi lain yang bersifat satu arah. Menggunakan metode Waterfall untuk pengembangan, aplikasi ini telah diuji dengan metode black box, menghasilkan umpan balik positif dari sekitar 85% pengguna yang merasa aplikasi ini efektif dan meningkatkan pelaporan kondisi sampah hingga 60% dibandingkan metode sebelumnya. Diharapkan, aplikasi ini akan meningkatkan partisipasi masyarakat dalam pengelolaan sampah, berkontribusi pada peningkatan kualitas lingkungan, mengurangi volume sampah yang tidak terkelola, serta meningkatkan kesadaran dan pendapatan lokal melalui pemanfaatan kembali dan daur ulang sampah.
Kata kunci — manajemen sampah, aplikasi berbasis web, metode waterfall
Effect of substrate-induced compressive strain on protonation of SrCoO2.5 epitaxial films
Authors: Xie Lingling , Isoda Yousuke , Nakamizo Shuri , Shen Yufan , Fuji Souta , Majima Takuya , Shimakawa Yuichi , Kan Daisuke 
Published: January 2025

Abstract
Electrochemical protonation, which can be realized in an electric-field-effect transistor with a gate layer consisting of a proton-conducting electrolyte Nafion membrane, offers a simple way of electrically tuning the physical properties of materials. In this study, we grew (010)-oriented epitaxial films of brownmillerite-structured SrCoO2.5 on various substrates whose lattice mismatch against SCO ranged from 0% to −2.9% by pulsed laser deposition and investigated the effect of substrate-induced strain on their protonation in field effect transistor structures with gate layers consisting of Nafion membranes. We found that the H concentration of the SCO films that were fully compressive-strained by up to 1.3% was ∼1.7 and that it was almost independent of the magnitude of the substrate-induced strain. We also found that the H content of the strain-partially-relaxed film with a residual compressive strain of 1.3% was lower, ∼1.3. These results indicate that lattice deformations arising from substrate-induced strain have insignificant effects on protonation, while lattice defects and dislocations introduced upon strain relaxation, which hinders proton diffusion in the films’ lattices, dominantly affect protonation in SrCoO2.5 films.
Selinexor (KPT-330) in Combination with Immune Checkpoint Inhibition in Uveal Melanoma: A Phase 1B Trial
Authors: Gouda Mohamed A. , Zarifa Abdulrazzak , Yang Yali , Stephen Bettzy , Gurses Serdar A. , Sprenger Ashabari , Tian Yanyan , Derbala Mohamed H. , Oliva Isabella Glitza , Meric-Bernstam Funda , Patel Sapna P. 
Published: January 2025

Introduction
Uveal melanoma remains a disease with aggressive behavior and poor prognosis despite advances in clinical management. Because monotherapy with immune checkpoint inhibitors has led to limited improvement in response rates, combination with other agents that act on the biological basis of oncogenesis has been proposed as a possible therapeutic strategy.

Methods
We designed a phase 1b trial to test the safety and tolerability of selinexor in combination with immune checkpoint inhibitors in patients with advanced uveal melanoma. Patients received selinexor 60 mg PO twice weekly with standard of care, commercially available immune checkpoint inhibitor of the investigator’s choice. In one patient receiving nivolumab and ipilimumab as the immunotherapy backbone, selinexor 60 mg PO was given once weekly.

Results
We included 10 patients with uveal melanoma who received treatment with either selinexor plus pembrolizumab (n = 9) or selinexor plus nivolumab and ipilimumab (n = 1). The most common adverse events of any grade were neutropenia, thrombocytopenia, leukopenia, and anemia. Additional common nonhematological toxicities included hyponatremia, nausea, and vomiting. Dose reductions were required in six patients (60%). Among nine patients with evaluable disease, eight had stable disease as the best response. The median progression-free and overall survival were 6 months (95% CI: 4, not reached and 17 months (95% CI: 7, not reached), respectively.

Conclusion
The combination of selinexor and immunotherapy was safe and showed a side effect profile consistent with previous reports. Clinical benefit was achieved in most patients and should be validated in larger phase 2 trials. ClinicalTrials.gov ID: NCT02419495.
Mechanical behaviour and structural characterization of human fascia lata
Authors: Szotek Sylwia , Dawidowicz Joanna , Maksymowicz Krzysztof 
Published: January 2025

Purpose
The fascia lata is a key structure determining the physiological functioning of knee and thigh muscles. At the same time it assures mechanical protection of the tissues situated beneath. This study aimed to clarify the comprehensive mechanical properties and microscopic structure of human fascia lata to understand its mechanical behaviour better.
Methods
The pathologically unchanged fascia lata used in this study were collected post-mortem from adult males of different age. The mechanical properties of the samples were determined under the uniaxial tensile test in two directions (longitudinal and transverse to collagen bundles arrangement). The structure observations were performed using a light and scanning electron microscope.
Results
The mechanical tests have shown the anisotropic properties of the examined tissue. The values of the particular mechanical parameters were determined. The maximum failure force, stiffness coefficient, tensile strength, and Young's modulus values were higher for longitudinal than transversal samples. Before the uniaxial tensile test, the collagen bundles within each layer of examined samples were aligned parallel to each other, showing a regular, wavy architecture (crisped pattern). The elastin fibres within these layers were much less numerous than collagen fibres. The applied mechanical forces disrupted the intact, regular collagen pattern, making the majority of collagen bundles loosely and irregularly oriented.
Conclusions
Knowledge of the mechanical and structural properties of the human fascia lata is an important issue in the context of clinical applications, tissue engineering as well as numerical modelling.
A new index for evaluating pedaling skill calculated from the pedaling efficiency index under gradually increasing load
Authors: Kitawaki Tomoki , Fukuda Masahiro 
Published: January 2025

Purpose
Measuring the pedal force vector during bicycle pedaling has recently become easy, and research has been conducted using mechanical efficiency (the ratio of an effective driving force to total pedaling force); however, the relationships between these forces were not considered. This study aimed to show that the relationship between these forces can be linearly regressed under gradually increasing load conditions and propose that the slope parameter can serve as a new index for evaluating pedaling skills.
Methods
Twenty-eight participants performed the experiment in which the load was increased every minute until the maximum load was exerted. Using sensors installed on both bicycle cranks, the pedaling force vector was divided into tangential and radial components to determine the total pedaling and effective driving forces per minute. The maximum load force and efficiency index were calculated.
Results
The results showed a strong linear relationship (coefficient of determination: 0.982, 95 % CI 0.909–0.996) between the total pedaling and effective driving force. The slope parameters from this regression exhibited significant correlations (-0.560 and -0.674) with the maximum load force and efficiency index during maximum exertion, respectively. These correlations highlight the slope parameter potential for capturing pedaling characteristics.
Conclusions
Conclusively, the slope parameter derived from the linear regression between the total pedaling force and effective driving force reflects individual pedaling characteristics. This parameter stands out as a promising new index for evaluating pedaling motion, offering insights into participant-specific pedaling behaviors. Consequently, this novel index could be instrumental in assessing and analyzing pedaling skills.
Antibiotic Prescribing Regimen and Resistance Awareness Among Eastern Libyan Dentists
Authors: Al-gadhy Ranya , Rabee Asmaa 
Published: January 2025

Background: The frequent use of antibiotics in dentistry for prophylaxis and treatment has contributed to a significant global public health issue: antibiotic resistance.
Aim: This research aims to evaluate the patterns in the prescription of antibiotics and their prophylactic usage in treating systemic conditions. Additionally, it investigates the awareness as well as adherence to guidelines for antibiotic prescription, as well as the awareness of antibiotic resistance among dentists with advanced degrees and postgraduate (AD) qualifications, and those with bachelor’s Degrees (BD) in the eastern region of Libya.
Materials and Methods: This cross-sectional study employed a questionnaire to gather data from a representative sample of 130 Libyan dentists in the eastern region (including Benghazi, Almarj, Albayda, Derna and Tobruk cities).
Results: Most of the antibiotics prescribed by dentists were amoxicillin with clavulanic acid followed by amoxicillin alone, and both participant groups were adherent to the recommendations for prescribing antibiotics with statistically significant variation between the two groups.
Conclusion: This study revealed a tendency to overprescribe and utilize antibiotics for particular dental diseases. The majority of dentists were aware of resistance to antibiotics and adhering to the antibiotic prescription guidelines, the participants acknowledged the recommended use of antibiotics as a preventive strategy for systemic conditions.