bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjustment of creatinine clearance for carboplatin dosing in Calvert's formula and clinical efficacy for lung cancer
Authors: Hatta Takahiro , Hase Tetsunari , Hara Toru , Kimura Tomoki , Kojima Eiji , Abe Takashi , Horio Yoshitsugu , Goto Yasuhiro , Ozawa Naoya , Yogo Naoyuki , Shibata Hirofumi , Shimokata Tomoya , Oguri Tetsuya , Yamamoto Masashi , Yanagisawa Kiyoshi , Ando Masahiko , Ando Yuichi , Kondo Masashi , Ishii Makoto , Hasegawa Yoshinori 
Published: June 2023

AbstractBackgroundThe Cockcroft–Gault formula is commonly used as a substitute for glomerular filtration rate (GFR) in Calvert's formula for carboplatin dosing, where adjusting serum creatinine measured using the enzymatic method with 0.2 mg/dL has been suggested in Japan. However, the effects of these adjustments on efficacy in patients with non‐small‐cell lung cancer remain unknown.MethodsWe conducted a post hoc analysis of the PREDICT1 study (CJLSG1201), a multicenter prospective observational trial of carboplatin–pemetrexed. Glomerular filtration rate values in Calvert's formula were back‐calculated from the administered dosages of carboplatin and the reported value of the target area under the curve. We estimated the serum creatinine adjustments and divided the patients into crude and adjusted groups.ResultsPatients in the crude group (N = 169) demonstrated similar efficacy to those in the adjusted group (N = 104) in progression‐free survival (PFS) and overall survival (OS) (hazard ratio [HR], 1.02; 95% confidence interval [CI], 0.76–1.35; p = 0.916 vs. HR, 0.87; 95% CI, 0.65–1.17; p = 0.363), with higher grade 3–4 hematologic toxicity. Among patients aged ≥75 years, the crude group (N = 47) showed superior efficacy compared with the adjusted group (N = 17) in PFS and OS (HR, 0.37; 95% CI, 0.20–0.69; p = 0.002 vs. HR, 0.43; 95% CI, 0.23–0.82; p = 0.010).ConclusionsSerum creatinine adjustment may be associated with similar efficacy compared to the crude serum creatinine value. In older patients, the adjustment should be cautiously applied owing to the potential for reduced efficacy.
Child‐Centred Play Therapy and Rhythmic Relating improves emotion regulation in autism: A single‐N pilot intervention study
Authors: Daniel Stuart , Berkovits Lauren , Eisenhower Abbey , Blacher Jan 
Published: June 2023

AbstractEmotion Regulation is a key factor in the psychological well‐being of children on the autism spectrum. Therapeutic co‐regulation is posited here as fundamental to addressing Emotion Regulation needs. A therapeutic combination of Child‐Centred Play Therapy and Rhythmic Relating is assessed in its potential to improve Emotion Regulation outcomes (over 10 months; 25 weekly sessions), via co‐regulatory experience, in a case study of a 5‐year‐old autistic boy. The parent‐rated Emotion Regulation Checklist (Shields & Cicchetti, Developmental Psychology, 33, 1997, 906) was completed every week. Mean Start and Finish scores were taken for checklist total and all subscales. Emotion Regulation percentage‐change‐over‐time values are calculated for the participant and, using percentiles, are compared and statistically ranked in relation to our comparison group: Autistic boys without concurrent cognitive impairment, not receiving psychological or behavioural therapies (over 10 months; N = 66). A graphical representation of Emotion Regulation demonstrates weekly change. As compared to our comparison group, our participant's overall Emotion Regulation improvements (over 10 months) are statistically likely to be due to his participation in therapy (p < 0.04). Graphical representation of Emotion Regulation over time demonstrates a compelling blind correlation between the period of significant positive change in our participant's Emotion Regulation and the therapist's clinical notes on positive change observed in the clinic.
New Olimycins from a Cold‐Seep‐Derived Streptomyces olivaceus
Authors: Dong Yun , Jin Enjing , Wang Runyi , Bao Yilei , Li Huayue 
Published: June 2023

AbstractCold‐seeps are areas of the ocean floor in which hydrogen sulfide and methane are released into the open water. The cold‐seep microbes are an emerging source of novel bioactive natural products. Four new ansa‐ring opened linear ansamycin analogues, named olimycins E−H (1–4) were isolated from the cold‐seep‐derived Streptomyces olivaceus OUCLQ19‐3. The planar and stereochemical structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses together with ECD calculations.
High performing male with fragile X syndrome with an unmethylated FMR1 full mutation: The relevance of clinical and genetic correlations
Authors: Shieh Meg , Amkraut Keren , Spiridigliozzi Gail A. , Adayev Tatyana , Nicholson Kaylea , McConkie‐Rosell Allyn , McDonald Marie , Pennington Malinda , Sebastian Siby , Lachiewicz Ave M. 
Published: June 2023

Key Clinical MessageA high performing male with an unmethylated full mutation in the fragile X messenger ribonucleoprotein 1 (FMR1) gene surpassed our expectations into young adulthood. Although initial genetic findings helped make a correct fragile X syndrome (FXS) determination, the report was insufficient. Ten years later, we repeated and conducted additional genetic and clinical studies to determine whether more information could assist with treatment and counseling. The genetic findings were very consistent with his high functioning and would have enabled us to be more confident about a good developmental outcome had they been available previously. As FXS enters the mainstream of well‐understood genetic disorders and technological advancements improve genetic tests, it should be clearer to clinical providers what a full FXS assessment could include to provide high quality information for care. For individuals with FXS who are high functioning, their families and clinical professionals would benefit from knowing more genetic findings, including, most importantly, methylation status, but also the FMR1 protein (FMRP) level and mRNA level. While we now know that obtaining only the CGG repeat number is not always adequate to inform accurate clinical care, future studies are likely to show the benefit of studying other biomarkers, such as mRNA levels.
Histopathologic diagnosis of ultra‐early autoimmune gastritis: A case report
Authors: Terao Shuichi , Suzuki Shiho , Kushima Ryoji 
Published: June 2023

Key Clinical MessageWe describe an ultra‐early stage of autoimmune gastritis (AIG) that occurs prior to the well‐known early‐stage AIG. The key pathology is the shortening of the second layer with degenerated parietal cells. In the management of patients with autoimmune diseases, AIG should be considered even if the endoscopy findings are normal.
Solitary median maxillary central incisor in association with taurodontism and oligodontia: A case report
Authors: Sheikhhassani Yasmin , Sarrafzadeh Arash , Jadidi Soheila 
Published: June 2023

Key Clinical MessageIn this case report, we have highlighted the probability of coinciding multiple dental anomalies, such as SMMCI, taurodontism, and oligodontia. Thus, further research is necessary to establish a correlation between oligodontia, taurodontism, and SMMCI.
Smegma pearl: A benign penile lesion in infants
Authors: Baral Kushal , Poudel Susmita 
Published: June 2023

Key clinical messageProvide comprehensive knowledge to healthcare practitioners regarding the benign characteristics of smegma pearls, aiming to alleviate anxiety and minimize unwarranted medical interventions.AbstractPenile nodules in infant are distressing to the mother and also cause diagnostic dilemmas to primary care physician. Most of the penile nodules are benign and the only treatment is reassurance to the mother. Smegma pearl occurs due to accumulation of the desquamated epithelial cells under the penile foreskin and are visualized as yellowish white lumps. We present a similar case who presented to the primary health centre at rural Nepal.
Complete hematologic response after belinostat treatment and allogeneic stem cell transplantation for multiple relapsed/refractory angioimmunoblastic T‐cell lymphoma: A case report
Authors: Camus Vincent , Etancelin Pascaline , Drieux Fanny , Veresezan Elena‐Liana , Picquenot Jean‐Michel , Penther Dominique , Viennot Mathieu , Ruminy Philippe , Contentin Nathalie , Lemasle Emilie , Leprêtre Stéphane , Dubois Sydney , Penichoux Juliette , Stamatoullas Aspasia , Zduniak Alexandra , Lanic Hélène , Jardin Fabrice 
Published: June 2023

Key Clinical MessageThis case report highlights the potential of belinostat for the treatment of relapsed/refractory peripheral T‐cell lymphomas, for which effective therapies are still scarce.AbstractPeripheral T‐cell lymphomas have an aggressive disease course associated with poor outcomes. We report a young patient with highly pretreated relapsed/refractory nodal follicular helper T‐cell lymphoma (angioimmunoblastic‐type [nTFHL‐AI]), who successfully received an allogeneic stem cell transplantation following belinostat therapy. The complete hematologic response achieved has lasted more than 2 years.
Pulmonary miliary sarcoidosis masquerading the reactivation of tuberculosis 30 years later
Authors: Okuma Takashi , Mizushima Reimi , Takeda Yukihisa , Toriyama Kazutoshi , Watanabe Yusuke , Nakamura Hiroyuki , Aoshiba Kazutetsu 
Published: June 2023

Key Clinical MessageSarcoidosis may occur after treatment with pulmonary tuberculosis and requires differential diagnosis from tuberculosis reactivation. Miliary sarcoidosis should be promptly differentiated from miliary tuberculosis associated with high mortality.AbstractClinical, histological, and radiological similarities between sarcoidosis and tuberculosis render differential diagnosis challenging. The association between these two diseases has long been discussed, although the coexistence or subsequent occurrence of tuberculosis and sarcoidosis is rare. We report a case of miliary sarcoidosis that developed 30 years after tuberculous pleurisy treatment. Sarcoidosis may occur after treatment with pulmonary tuberculosis and requires differential diagnosis from tuberculosis reactivation. Although miliary sarcoidosis is uncommon, it should be promptly differentiated from miliary tuberculosis associated with high mortality. This study reignites the debate on the causal association between tuberculosis and sarcoidosis.
Accelerated Polymerization of Lactide Driven by a DBU‐based Salt and a 15‐Crown‐5 Ether Sacrificial Kinetic Booster
Authors: Moins Sébastien , Coulembier Olivier 
Published: June 2023

AbstractThe recent advances in polymerization of lactide (LA) from organic salts enriched the toolbox to prepare well‐defined materials. Herein we report the use of crown ether (CE) as an additive to polymerize the L‐LA when initiated by 12‐hydroxydodecanoic acid (HDA) activated by one equivalent of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU). While both size and structure of the ether additive play an important role on the overall rate of reaction, the CE decomplexation is crucial to outpace transfer reactions and also permit the process to be moderately conducted under air atmosphere by an efficient water trapping process.
Shining Light on Carbon Dots: New Opportunities in Photocatalysis
Authors: Sbacchi Maria , Mamone Martina , Morbiato Laura , Gobbo Pierangelo , Filippini Giacomo , Prato Maurizio 
Published: June 2023

AbstractPhotocatalysis is an emerging field that exploits light‐absorbing catalysts to yield transformations not even achievable in the dark. Considering the drawbacks of metal‐based photocatalysts, Carbon Dots (CDs) recently emerged as suitable green alternatives for different photocatalytic reactions. These carbon nanoparticles are easy to prepare, non‐toxic and potentially recyclable. Moreover, CDs usually display core‐shell structures which are highly tunable via synthetic and post‐synthetic strategies. This Concept Article focuses on the recent advancements in the CD‐based photocatalysis, highlighting the link between their superficial and core composition and their resulting photo‐redox abilities, and giving future perspectives on their application in cutting‐edge areas.
γ‐Hydroxybuttersäure
Authors: Theofel Nadine , Tsokos Michael , Scholtis Stefan 
Published: June 2023

ZusammenfassungDie Analyse und Interpretation von GHB‐Konzentrationen ist alles andere als trivial. Dies ist insbesondere im forensisch‐toxikologischen Umfeld der Fall. So muss zum einen die endogene Konzentration berücksichtigt werden und zum anderen der Umstand, dass GHB nach Eintritt des Todes noch gebildet werden kann. Hinzu kommt, dass Untersuchungen hinsichtlich GHB zusätzlich angefordert werden müssen, da GHB im Rahmen der Systematischen Toxikologischen Analyse nicht untersucht wird. Weiterhin ist das Nachweisfenster von GHB in Blut oder Urin sehr kurz. Die Analyse erfolgt in der Regel mit chromatographischen Systemen, die an ein Massenspektrometer gekoppelt sind. Dieser Aufsatz fasst die GHB‐positiven Fälle der letzten fünf Jahre zusammen und stellt zwei Fälle detaillierter vor.
One‐Pot Synthesis of Axially and Centrally Chiral A‐type Nanogrids
Authors: Wei Ying , Du Xue , Huang Wan‐Xin , Fu Ming‐Yang , Zhang Zheng , Zhong Chun‐Xiao , Wang Yi‐Ru , Ling Hai‐Feng , Xie Ling‐Hai , Huang Wei 
Published: June 2023

Comprehensive SummaryA novel type of A‐type nanogrids (AGs) with axial and central chirality was synthesized via Friedel‐Crafts gridization of thiophenes and difluorenyl biaromatic derivatives, yielding 9%—30%. Additionally, the effect of stereoisomers of 1,1’‐binaphthyl difluorenols (BINDFOH) was investigated to demonstrate that R/S‐BINDFOH is more advantageous for the synthesis of AGs than Mix‐BINDFOH. Furthermore, tests on OFET memory devices showed that AGs have a larger storage window, indicating potential for data storage applications.
Queuine Analogues Incorporating the 7‐Aminomethyl‐7‐deazaguanine Core: Structure–Activity Relationships in the Treatment of Experimental Autoimmune Encephalomyelitis
Authors: Cotter Michelle , Varghese Sreeja , Chevot Franciane , Fergus Claire , Kelly Vincent P. , Connon Stephen J. , Southern J. Mike 
Published: June 2023

AbstractA library of queuine analogues targeting the modification of tRNA isoacceptors for Asp, Asn, His and Tyr catalysed by queuine tRNA ribosyltransferase (QTRT, also known as TGT) was evaluated in the treatment of a chronic multiple sclerosis model: murine experimental autoimmune encephalomyelitis. Several active 7‐deazaguanines emerged, together with a structure–activity relationship involving the necessity for a flexible alkyl chain of fixed length.
Cannabis use among adults undergoing cancer treatment
Authors: Azizoddin Desiree R. , Cohn Amy M. , Ulahannan Susanna V. , Henson Christina E. , Alexander Adam C. , Moore Kathleen N. , Holman Laura L. , Boozary Laili Kharazi , Sifat Munjireen S. , Kendzor Darla E. 
Published: June 2023

AbstractBackgroundLittle is known about the risks and benefits of cannabis use in the context of cancer care. This study characterized the prevalence, reasons for use, and perceived benefits of cannabis and compared symptoms and perceived risks between those who reported past 30‐day cannabis use and those who did not.MethodsAdults undergoing cancer treatment at a National Cancer Institute–designated cancer center completed measures of sociodemographic characteristics, cannabis use, use modalities, reasons for use, perceived harms/benefits of use, physical and psychological symptoms, and other substance/medication use. Analyses compared patients who used or did not use cannabis in the past 30 days.ResultsParticipants (N = 267) were 58 years old on average, primarily female (70%), and predominantly White (88%). Over a quarter of respondents (26%) reported past 30‐day cannabis use, and among those, 4.5% screened positive for cannabis use disorder. Participants who used cannabis most often used edibles (65%) or smoked cannabis (51%), and they were younger and more likely to be male, Black, and disabled, and to have lower income and Medicaid insurance than participants who did not use cannabis. Those who used cannabis reported more severe symptoms and perceived cannabis as less harmful than those who did not use cannabis. The most common medical reasons for cannabis use were pain, cancer, sleep problems, anxiety, nausea/vomiting, and poor appetite. Participants reported the greatest cannabis‐related symptom relief from sleep problems, nausea/vomiting, headaches, pain, muscle spasms, and anxiety.ConclusionsPatients with cancer who used cannabis perceived benefits for many symptoms, although they showed worse overall symptomatology.Plain language summary

Among adults undergoing cancer treatment, 26% reported cannabis use in the past 30 days. Those who used cannabis were more likely to be male and disabled and to have lower income and Medicaid insurance than those who did not use cannabis.
Participants most commonly reported using cannabis for pain, cancer, sleep, anxiety, and nausea/vomiting and reported the greatest perceived benefits for sleep, nausea/vomiting, headaches, pain, muscle spasms, and anxiety, yet participants who used cannabis also reported feeling worse physically and psychologically compared to those who did not use cannabis.
Participants who used cannabis were more likely to report that cannabis was less risky to their health than alcohol, smoking, and opioids than those who did not use cannabis.
Longitudinal strain analysis for assessment of early cardiotoxicity during anthracycline treatment in childhood sarcoma: A single center experience
Authors: Alpman Maria Sjöborg , Jarting Annica , Magnusson Kerstin , Manouras Aristomenis , Henter Jan‐Inge , Broberg Agneta Månsson , Herold Nikolas 
Published: June 2023

AbstractBackgroundThe growing population of long‐term childhood cancer survivors encounter a substantial burden of cardiovascular complications. The highest risk of cardiovascular complications is associated with exposure to anthracyclines and chest radiation. Longitudinal cardiovascular surveillance is recommended for childhood cancer patients; however, the optimal methods and timing are yet to be elucidated.AimsWe aimed to investigate the feasibility of different echocardiographic methods to evaluate left ventricular systolic function in retrospective datasets, including left ventricular ejection fraction (LVEF), fractional shortening (FS), global longitudinal strain (GLS) and longitudinal strain (LS) as well as the incidence and timing of subclinical left ventricular dysfunction detected by these methods.Methods and ResultsA retrospective longitudinal study was performed with re‐analysis of longitudinal echocardiographic data, acquired during treatment and early follow‐up, including 41 pediatric sarcoma patients, aged 2.1–17.8 years at diagnosis, treated at Astrid Lindgren Children's Hospital, Stockholm, Sweden, during the period 2010–2021. All patients had received treatment according to protocols including high cumulative doxorubicin equivalent doses (≥250 mg/m2). In 68% of all 366 echocardiograms, LS analysis was feasible. Impaired LS values (<17%) was demonstrated in >40%, with concomitant impairment of either LVEF or FS in 20% and combined impairment of both LVEF and FS in <10%. Importantly, there were no cases of abnormal LVEF and FS without concomitant LS impairment.ConclusionOur findings demonstrate feasibility of LS in a majority of echocardiograms and a high incidence of impaired LS during anthracycline treatment for childhood sarcoma. We propose inclusion of LS in pediatric echocardiographic surveillance protocols.
Context‐aware application scheduling in fog computing environment
Authors: Islam Mir Salim Ul , Kumar Ashok 
Published: June 2023

AbstractFog computing emerges as the new computing environment that stays in the proximity of end‐users and harnesses resources at the edge of the network to extend cloud‐facilities. It provides attractive solutions to the diverse range of Internet of Things (IoT) applications by executing them in the vicinity of end‐users. It is challenging to schedule these latency‐sensitive, computation‐intensive, and resource‐hungry applications on distributed, heterogeneous, and resource‐constrained Fog computing environment while ensuring time‐bound service delivery and satisfying Quality of Service (QoS) requirements of end‐users. In this paper, a context‐aware application scheduling technique is proposed for Fog computing environments that employs various parameters of device‐ and application‐level context to minimize service delivery time and satisfy QoS requirements of various IoT applications such as surveillance and game‐based applications. The performance of the proposed technique is evaluated in a simulated Fog environment and compared with baseline application scheduling techniques. The simulation results demonstrate that the proposed context‐aware scheduling techniques result in significant improvement in service delivery time and QoS compared to baseline scheduling techniques.
Adsorption and Aggregation Behavior in Aqueous Solution of Tetrasiloxane‐based Carboxylate Surfactants via “Thiol‐ene” Photochemical Reaction
Authors: Meng Lina , Wang Wenyu , Li Lei , Feng Shengyu 
Published: June 2023

AbstractAnionic silicone surfactants have long been a neglected field. In this paper three anionic silicone surfactants were synthesized first time from dichloromethylvinylsilane through hydrolysis‐condensation, “thiol‐ene” photo‐ chemical and then salting reaction. The critical aggregate concentration (CAC), surface tension, minimum surface area per surfactant molecule and surface pressure at CAC were studied by both surface tension and electrical conductivity. The results showed that they had significant surface activity at the gas/liquid interface and were capable to reduce the surface tension of water to approximately 20 mN m−1. The results of transmission electron microscopy showed that the three silicone surfactants self‐assembled into spherical aggregates of uniform size in aqueous solution above the CAC. The dynamic light scattering results demonstrated that the size of the aggregates was determined to be in the range from 60 to 300 nm at 0.05 mol L−1 and the order of the size of the aggregates is (Me3SiO)3SiCO2Li<(Me3SiO)3SiCO2Na<(Me3SiO)3SiCO2K.
Genotypic variation in germination rate, seedling vigor, and seed phenotype of Kentucky bluegrass cultivars
Authors: Folck Amanda J. , Bigelow Cale A. , Jiang Yiwei , Patton Aaron J. 
Published: June 2023

AbstractKentucky bluegrass (Poa pratensis L.) is the most widely used cool‐season turfgrass for athletic fields, but its seeds germinate slowly. The objective was to determine the germination rate, seedling vigor, and seed phenotype of Kentucky bluegrass cultivars. Germination and seedling vigor tests were conducted using a seed incubator set at alternating 25/15°C (day/night) temperatures and an 8 h day−1 photoperiod. Twenty‐one cultivars were tested using two seed lots for each. Germination was most rapid among the experimental genotype PST‐T15‐44 and the commercial cultivar "After Midnight, as they took the minimum days to reach 50% germination in only 7.9–8.0 or 8.8 days, respectively. Cultivars Tirem and Volt required >12 days in both lots to reach 50% germination (12.0–13.7 days). There was a difference of 5–6 days in 50% germination between cultivars. Seedling vigor was also measured but few differences between cultivars were noted. Data on seed phenotype including seed length, width, area, circularity, and thousand seed weights (TSW) all varied by cultivar. ‘‘After Midnight’’ had the longest seeds (3.065 mm). ‘‘Moonlight SLT’’ seeds were the shortest in length (2.366 mm), narrowest in width (0.717 mm), and smallest in area (1.328 cm2). Across all cultivars, seed length and circularity were correlated with germination rate (r = 0.62, p = 0.0025; r = −0.53, p = 0.0141). Seed phenotyping could be an important tool in breeding for improved germination rate. By identifying and using rapidly germinating Kentucky bluegrass cultivars, it may be possible to establish turf more rapidly.