bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating biomarkers are associated with disease severity of chronic hand eczema and atopic dermatitis
Authors: Quaade Anna S , Wang Xing , Sølberg Julie B K , Ulrich Nina H , McCauley Benjamin D , Thyssen Jacob P , Becker Christine , Johansen Jeanne D 
Published: April 2023

Abstract

Background
Although chronic hand eczema (CHE) is a highly prevalent and disabling skin disease, it is currently unknown if CHE is associated with systemic inflammation.

Objectives
To characterize the plasma inflammatory signature of CHE.

Methods
Using Proximity Extension Assay technology, we assessed 266 inflammatory and cardiovascular disease risk proteins in the plasma of 40 healthy controls, 57 patients with atopic dermatitis (AD) with active lesions, 11 with CHE and a history of AD (CHEPREVIOUS_AD), and 40 with CHE and no history of AD (CHENO_AD). Filaggrin gene mutation status was also assessed. Protein expression was compared between groups and according to disease severity. Correlation analyses for biomarkers, and clinical- and self-reported variables, were performed.

Results
Very severe CHENO_AD was associated with systemic inflammation when compared with controls. Levels of T helper (Th)2- and Th1-, general inflammation and eosinophil activation markers increased with severity of CHENO_AD, primarily being significantly increased in very severe disease. Significant, positive correlations were found between markers from these pathways and severity of CHENO_AD. Moderate-to-severe but not mild AD displayed systemic inflammation. The Th2 markers C-C motif chemokine (CCL)17 and CCL13 (also known as monocyte chemotactic protein 4) were the top differentially expressed proteins in both very severe CHENO_AD and moderate-to-severe AD, showing a higher fold change and significance in AD. CCL17 and CCL13 levels further correlated positively with disease severity in both CHENO_AD and AD.

Conclusions
Systemic Th2-driven inflammation is shared between very severe CHE with no history of AD, and moderate-to-severe AD, suggesting that Th2 cell targeting could be effective in several CHE subtypes.
Decolonizing ELT materials: a sociomaterial orientation
Authors: Kim Miso 
Published: April 2023

Abstract
This article adopts a sociomaterial perspective on ELT materials and illustrates how a mandatory textbook is used as a springboard to create decolonizing relations in the classroom ecology. Sociomaterial perspectives view learning as not the transmission but the emergence of knowledge from embodied relations, which shifts the focus from the textbook itself to the relations surrounding it. Based on this shift, this article first provides exploratory questions for teachers to understand the classroom ecology. A set of example activities in a beginner-level Japanese EFL class follows, which showcase how a textbook published by a global publisher could be turned into a springboard to attract translingual and multimodal materials and meaning-making resources. Learning emerges through the entangled relationships of the prescribed textbook, materials, resources, students, and teachers. The article concludes with practical implications to enrich the ELT classroom ecology.
Social media and hiring: a survey experiment on discrimination based on online social class cues
Authors: Galos Diana Roxana 
Published: April 2023

Abstract
Discrimination based on social class is challenging to study, and therefore likely to be underappreciated due to its subtle nature. Social class is often difficult to gauge from traditional resumes, yet, the expansion of social networking platforms provides employers with an additional source of information. Given that many individuals have a social media presence today, employers can increasingly rely on additional information gleaned from such online platforms (e.g., Twitter, Instagram), which may alter hiring decisions. To study the role of social networking platforms vis-à-vis potential discrimination based on social class cues, I leverage an original online survey experiment in the United States. The aim of the investigation is (i) to measure the effect of cultural markers of social class expressed on social media profiles in a hypothetical hiring situation and (ii) to analyse potential channels that might explain class-based discrimination. I show that subjects favour the upper-class-signalling candidate over the lower-class-signalling candidate and that perceived competence and perceived warmth are two channels through which class-based discrimination may occur. The individual’s online presence might not be part of the formal application process, yet it seems to shape inferences about individuals’ employability, competence, and warmth.
Environmental drivers of the current and future distribution of high-yielding lacquer trees (Toxicodendron vernicifluum (stokes) F. A. Barkley)
Authors: Zhang Shuqiao , Wang Zizhi , Liao Shengxi 
Published: April 2023

Abstract
Lacquer trees (Toxicodendron vernicifluum (Stokes) F.A. Barkley) are an important natural resource with significant economic and cultural value in East Asia. The main product, raw lacquer, is in high demand due to its commercially valuable characteristics. This study analyzed environmental drivers of the current and future distribution of lacquer trees in high-yielding locations using a machine-learning algorithm and Maxent models. Results identified suitable value ranges for four key environmental variables and their relative contribution to environmentally suitable areas (shown as percentages in parentheses): solar radiation, 12 000–13 000 kJ m−2 day−1 (43.1 per cent); min temperature of the coldest month, −3.5 to 3°C (18.7 per cent); annual precipitation, 900–1400 mm (13.9 per cent) and water vapour pressure, 1.2–1.6 KPa (5.1 per cent). Overall, projected climate change until 2100 will reduce the extent of environments suitable for high-yielding lacquer trees in China and the Republic of Korea, although these areas will expand in Japan. In addition to the three East Asian countries in which lacquer trees and production are currently important, the study identified environmentally suitable areas for growing lacquer trees in other countries worldwide under future climate conditions. The study’s methodology, which divided high-yielding records from other occurrence records and modeled them separately, was applicable in analyzing environmental drivers and modelling suitable areas for lacquer trees. This approach may also be beneficial to study the distributions of other plants, especially economically important crops and trees. In future studies, additional data sets capturing anthropogenic drivers and information on single tree level could further improve models exploring the productivity and sustainability of lacquer trees under future climates.
Prevalence of intestinal parasitic infections in patients with diabetes: a systematic review and meta-analysis
Authors: Taghipour Ali , Javanmard Ehsan , Rahimi Hanieh Mohammad , Abdoli Amir , Matin Sara , Haghbin Marzieh , Olfatifar Meysam , Mirjalali Hamed , Zali Mohammad Reza 
Published: April 2023

AbstractPatients with diabetes are at an increased risk of intestinal parasitic infections (IPIs). We evaluated the pooled prevalence and OR of IPIs in patients with diabetes through a systematic review and meta-analysis. A systematic search was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol for studies reporting IPIs in patients with diabetes through 1 August 2022. The collected data were analyzed using comprehensive meta-analysis software version 2. Thirteen case-control studies and nine cross-sectional studies were included in this study. The overall prevalence of IPIs in patients with diabetes was calculated to be 24.4% (95% CI 18.8 to 31%). Considering the case-control design, the prevalence of IPIs in case (25.7%; 95% CI 18.4 to 34.5%) was higher than controls (15.5%; 95% CI 8.4 to 26.9%) and a significant correlation was observed (OR, 1.80; 95% CI 1.08 to 2.97%). Moreover, a significant correlation was seen in the prevalence of Cryptosporidium spp. (OR, 3.30%; 95% CI 1.86 to 5.86%), Blastocystis sp. (OR, 1.57%; 95% CI 1.11 to 2.22%) and hookworm (OR, 6.09%; 95% CI 1.11 to 33.41%) in the cases group. The present results revealed a higher prevalence of IPIs in patients with diabetes than in controls. Therefore, the results of this study suggest a proper health education program to preventing measures for the acquisition of IPIs in patients with diabetes.
Induction of allograft tolerance by adoptive transfer of donor B cells: an immune regulatory strategy for transplantation using MHC-matched iPS cells
Authors: Murata Tomoki , Otsuka Ryo , Sasaki Airi , Kamatani Tomoki , Wada Haruka , Yamakawa Hisashi , Hasegawa Yoshinori , Seino Ken-ichiro 
Published: April 2023

Abstract
For cellular or tissue transplantation using induced pluripotent stem cells (iPSCs), from the viewpoint of time and economic cost, the use of allogeneic ones is being considered. Immune regulation is one of the key issues in successful allogeneic transplantation. To reduce the risk of rejection, several attempts have been reported to eliminate effects of the major histocompatibility complex (MHC) on the iPSC-derived grafts. On the other hand, we have shown that minor antigen-induced rejection is not negligible even when the MHC’s impact is mitigated. In organ transplantation, it is known that donor-specific transfusion (DST) can specifically control immune responses to the donor. However, whether DST could control the immune response in iPSC-based transplantation was not clarified. In this study, using a mouse skin transplantation model, we demonstrate that infusion of donor splenocytes can promote allograft tolerance in the MHC-matched but minor antigen-mismatched conditions. When narrowing down the cell types, we found that infusion of isolated splenic B cells was sufficient to control rejection. As a mechanism, the administration of donor B cells induced unresponsiveness but not deletion in recipient T cells, suggesting that the tolerance was induced in the periphery. The donor B cell transfusion induced allogeneic iPSC engraftment. These results suggest for the first time a possibility that DST using donor B cells could induce tolerance against allogeneic iPSC-derived grafts.
Of Love and Frustration as Post-Yugoslav Women Scholars: Learning and Unlearning the Coloniality of IR in the Context of Global North Academia
Authors: Stavrevska Elena B , Lazic Sladjana , Musliu Vjosa , Karabegović Dženeta , Sardelić Julija , Obradovic-Wochnik Jelena 
Published: April 2023

AbstractThis collective discussion brings together six women scholars of and from the post-Yugoslav space, who, using personal experiences, analyze the dynamics of knowledge production in international relations (IR), especially regarding the post-Yugoslav space. Working in Global North academia but with lived experiences in the region we study, our research is often subjected to a particular gaze, seeped in assumptions about “ulterior” motives and expectations about writing and representation. Can those expected to be objects of knowledge ever become epistemic subjects? We argue that the rendering of the post-Yugoslav space as conflict-prone and as Europe's liminal semi-periphery in the discipline of IR cannot be decoupled from the rendering of the region and those seen as related to it as unable to produce knowledge that, in mainstream discussions, is seen as valuable and “objective.” The post-Yugoslav region and those seen as related to it being simultaneously postcolonial, postsocialist, and postwar, and characterized by marginalization, complicity, and privilege in global racialized hierarchies at the same time, can make visible specific forms of multiple colonialities, potentially creating space for anti- and/or decolonial alternatives. We further make the case for embracing a radical reflexivity that is active, collaborative, and rooted in feminist epistemologies and political commitments.
Assessing an electronic self-report method for improving quality of ethnicity and race data in the Veterans Health Administration
Authors: Almklov Erin , Cohen Alicia J , Russell Lauren E , Mor Maria K , Fine Michael J , Hausmann Leslie R M , Moy Ernest , Washington Donna L , Jones Kenneth T , Long Judith A , Pittman James 
Published: April 2023

AbstractObjectiveEvaluate self-reported electronic screening (eScreening) in a VA Transition Care Management Program (TCM) to improve the accuracy and completeness of administrative ethnicity and race data.Materials and MethodsWe compared missing, declined, and complete (neither missing nor declined) rates between (1) TCM-eScreening (ethnicity and race entered into electronic tablet directly by patient using eScreening), (2) TCM-EHR (Veteran-completed paper form plus interview, data entered by staff), and (3) Standard-EHR (multiple processes, data entered by staff). The TCM-eScreening (n = 7113) and TCM-EHR groups (n = 7113) included post-9/11 Veterans. Standard-EHR Veterans included all non-TCM Gulf War and post-9/11 Veterans at VA San Diego (n = 92 921).ResultsEthnicity: TCM-eScreening had lower rates of missingness than TCM-EHR and Standard-EHR (3.0% vs 5.3% and 8.6%, respectively, P &lt; .05), but higher rates of “decline to answer” (7% vs 0.5% and 1.2%, P &lt; .05). TCM-EHR had higher data completeness than TCM-eScreening and Standard-EHR (94.2% vs 90% and 90.2%, respectively, P &lt; .05). Race: No differences between TCM-eScreening and TCM-EHR for missingness (3.5% vs 3.4%, P &gt; .05) or data completeness (89.9% vs 91%, P &gt; .05). Both had better data completeness than Standard-EHR (P &lt; .05), which despite the lowest rate of “decline to answer” (3%) had the highest missingness (10.3%) and lowest overall completeness (86.6%). There was strong agreement between TCM-eScreening and TCM-EHR for ethnicity (Kappa = .92) and for Asian, Black, and White Veteran race (Kappas = .87 to .97), but lower agreement for American Indian/Alaska Native (Kappa = .59) and Native Hawaiian/Other Pacific Islander (Kappa = .50) Veterans.ConculsionseScreening is a promising method for improving ethnicity and race data accuracy and completeness in VA.
Effects of adding ruminal propionate on dry matter intake and glucose metabolism in steers fed a finishing ration
Authors: Rathert-Williams Abigail R , McConnell Hunter L , Salisbury Carlee M , Lindholm-Perry Amanda K , Lalman David L , Pezeshki Adel , Foote Andrew P 
Published: April 2023

Abstract
The objective of this experiment was to determine if supplying additional propionate to the rumen alters dry matter intake (DMI), feeding behavior, glucose metabolism, and rumen fluid metabolites in steers fed a finishing diet. Ruminally cannulated steers (n = 6) were fed a finishing diet ad libitum. Steers were randomly assigned to one of three treatments in a 3 × 6 Latin rectangle design with three 15 d periods. Treatments of no Ca propionate (Control), 100 g/d (Low), or 300 g/d (High) were ruminally dosed twice daily. Individual intake was measured using an Insentec feeding system. Pre-feeding blood samples were collected on day 7 and rumen fluid samples were collected on day 13. An intravenous glucose tolerance test (IVGTT) was conducted on day 14 and liver biopsies were collected on day 15. Liver samples were analyzed for expression of genes involved in gluconeogenesis. Data were analyzed using a mixed model with period, treatment, day, and their interaction included, with day and minute within period as a repeated measure and steer as a random effect. Meal size (P = 0.049), meal frequency (P = 0.046), and DMI (P &lt; 0.001) were decreased in High steers. Day 7 plasma glucose (P = 0.23) and lactate (P = 0.47) were not affected by treatment, but insulin was decreased (P = 0.008) and non-esterified fatty acids were increased (P = 0.044) in the High treatment compared with the Control. Rumen fluid lactate was decreased (P = 0.015) in the High treatment compared with the Low treatment. Total VFA concentrations did not differ (P = 0.88) between treatments. There was treatment × time interaction for proportions of acetate and propionate (P &lt; 0.001) and the acetate:propionate ratio (P = 0.005). The effect on acetate was due to a decrease in the High treatment 2 h after dosing the treatment. Propionate proportions were greater in the High treatment than the Control at all time points and differed from the Low except at 0 h. Propionate treatments had no major effects on the glucose and insulin parameters observed in the IVGTT other than a tendency (P = 0.09) for an increased insulin time to peak. These data indicate that exogenous propionate decreases DMI but the decrease in propionate from fermentation due to reduced DMI might negate the supply of exogenous propionate in VFA supply to the animal. Mechanisms other than hepatic oxidation of propionate might be responsible for DMI regulation.
American Burn Association Clinical Practice Guidelines on the Treatment of Severe Frostbite
Authors: Wibbenmeyer Lucy , Lacey Alexandra M , Endorf Frederick W , Logsetty Sarvesh , Wagner Anne L L , Gibson Angela L F , Nygaard Rachel M 
Published: April 2023

Abstract
This Clinical Practice Guideline addresses severe frostbite treatment. We defined severe frostbite as atmospheric cooling that results in a perfusion deficit to the extremities. We limited our review to adults and excluded cold contact or rapid freeze injuries that resulted in isolated devitalized tissue. After developing population, intervention, comparator, outcomes (PICO) questions, a comprehensive literature search was conducted with the help of a professional medical librarian. Available literature was reviewed and systematically evaluated. Recommendations based on the available scientific evidence were formulated through consensus of a multidisciplinary committee. We conditionally recommend the use of rapid rewarming in a 38 to 42°C water bath and the use of thrombolytics for fewer amputations and/or a more distal level of amputation. We conditionally recommend the use of “early” administration of thrombolytics (≤12 hours from rewarming) compared to “later” administration of thrombolytics for fewer amputations and/or a more distal level of amputation. No recommendation could be formed on the use of vascular imaging studies to determine the use of and/or the time to initiate thrombolytic therapy. No recommendation could be formed on the use of intravenous thrombolytics compared to the use of intra-arterial thrombolytics on fewer amputations and/or a more distal level of amputation. No recommendation could be formed on the use of iloprost resulting in fewer amputations and/or more distal levels of amputation. No recommendation could be formed on the use of diagnostic imaging modalities for surgical planning on fewer amputations, a more distal level of amputation, or earlier timing of amputation.
Validation of the water content of the digestive gland as an indicator of nutritional condition in the American lobsterHomarus americanus(H. Milne Edwards, 1837) (Decapoda: Nephropidae)
Authors: Couillard Catherine M , Maltais Domynick , Bruneau Benoît , Asselin Natalie , Boudreau Stephanie A 
Published: April 2023

AbstractSimple nutritional condition indicators are needed to provide information on the influence of ecosystem changes on the populations of the American lobster Homarus americanus (H. Milne Edwards, 1837) on various timescales. This study validates the use of the water content (% wet mass) of the digestive gland as an indicator of nutritional condition in the lobster (carapace length 65–127 mm) by assessing its capacity to estimate digestive-gland lipid reserves under variable environmental and physiological conditions. The validation was completed using samples from wild lobsters dissected shortly after being captured during different seasons and in various locations in the St. Lawrence Estuary and Gulf of St. Lawrence (GSL), and data from an environmentally realistic laboratory study on post-ovigerous females from the southern and the northern GSL sampled at different stages of their molt cycle. In both wild and experimental lobsters, water content was the best predictor of lipid reserves compared to other condition indicators (i.e., condition factor, various digestive-gland indices, and hemolymph Brix index). A strong linear relationship was found between lipid and water contents. Lipid content and interrelated molting status were identified as two important factors leading to the variations in water-fat regression equations among groups of wild or experimental lobsters. As lipid content could vary spatiotemporally in unexpected ways in a changing environment, it is recommended to use a sampling event-specific regression line to estimate digestive-gland lipid content from measured water content in field monitoring programs. Combining water content with molt status indicators such as Brix index is recommended to support interpretation of the observed variations in condition.
Mitochondrial genetic diversity ofThrips tabaci(Thysanoptera: Thripidae) in onion growing regions of the United States
Authors: Iftikhar Romana , Ghosh Amalendu , Pappu Hanu R 
Published: April 2023

AbstractOnion thrips (Thrips tabaci Lindeman, Thysanoptera: Thripidae) causes severe damage to many horticultural and agronomic crops worldwide. It also acts as a vector of several plant viruses. T. tabaci is a key pest of Allium cepa in the United States. However, there is limited information available on the genetic variation within and between T. tabaci populations in the United States and its key evolutionary parameters. In the current study, 83 T. tabaci specimens were collected from A. cepa from 15 different locations comprising four states of the United States. A total of 92 mtCOI gene sequences of T. tabaci from A. cepa were analyzed to understand the genetic diversity and structure of T. tabaci collected from onion host. Seven distinct haplotypes of T. tabaci infesting A. cepa were identified from the current collection, while nine T. tabaci sequences retrieved from GenBank comprised 5 haplotypes. Overall, 15 haplotypes of T. tabaci infesting A. cepa were identified in the world that includes the ten haplotypes in the United States. In the phylogenetic analysis, all the populations collected during the study clustered with thelytokous lineage, while T. tabaci sequences retrieved from GenBank corresponded to leek-associated arrhenotokous lineage. The highest genetic variation was found in Elba and Malheur populations with 3 haplotypes identified in each. The results suggest that haplotypes 1 and 7 are more frequently prevailing haplotypes in the north-western United States, with haplotype 1 being the predominant all over the country. The eastern United States appears to have a more diverse group of haplotypes. The populations from Hungary constituted distinct haplotypes and a haplotype from Kingston linked it with the predominant haplotype.