bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the Impact of Climate Change on Residential Footing Design in Australia: A Case Study Analysis
Authors: Sun Xi , Li Jie , Ren Gang 
Published: July 2023

AbstractThe impact of climate change on building performance is anticipated to be significant, affecting both present and future constructions on clay soils. In Australia, the Thornthwaite Moisture Index (TMI) is widely used to classify climate zones and determine the characteristic ground movement for designing residential footings. However, the existing TMI map provided by the Australian Standard AS2870 for Victoria, Australia, is based on meteorological data from 1940 to 1960, an outdated and thus potentially insufficient basis for current and future climate scenarios. To address this challenge, the study endeavours to develop an updated TMI map using weather data over a 20-year period (1994–2013) with predictions for 2030 and 2070 based on climate models to visualize climate zone changes. The updated TMI map shows significant changes in climate zones and suggests that current footing designs may be inadequate for future weather conditions. A case study was conducted to evaluate the influence of climate change on footing size and construction material cost. The findings indicate that the footing constructed in 1992 is inadequate for the projected climatic conditions of 2070. Coping with such severe weather scenarios necessitates larger footing sizes and upgrading steel reinforcements, raising the material cost by approximately 111%.
Touching and Being Touched During Physiotherapy Exercise Instruction
Authors: Keel Sara , Caviglia Cornelia 
Published: July 2023

AbstractThis contribution focuses on a physiotherapy consultation in which the first author of the contribution is the patient and the second author is the physiotherapist. It features analysis of video excerpts in which (1) the physiotherapist instructs the patient how to do an exercise and (2) the patient turns the physiotherapist's instructions into a course of action while (3) the physiotherapist monitors, assesses, guides, and corrects the patient's instructed actions by deploying touch. The investigation draws on video-recordings and transcriptions of the physiotherapist’s and the patient’s interaction during the exercise instructions, the authors’ experience of touching/being touched during these instructions, and their shared understandings as discussed during data-sessions devoted to select video-clips of exercise instructions. In a learning process, the instructor’s instructional corrections are critical: they provide learners with relevant specifications and explanations as to how instructed actions and/or remedial actions are to be accomplished. Whereas monitoring and touching the patient allows the physiotherapist to feel, assess, correct, and guide the patient’s instructed actions, being touched permits the patient to feel how the physiotherapist’s touch resonates beyond locally circumscribed body contact and adapt her movements accordingly. Our contribution thus reveals touching/being touched configurations that establish joint attention and action on extended sensoriality as forming constitutive parts of a dynamic sensorimotor process of inter- and intrabodily resonance, which is challenging to investigate.
Co-designing psychosis simulated patient scenarios with mental health stakeholders for pharmacy curricula
Authors: Ung Tina X. , O’Reilly Claire L. , Moles Rebekah J. , El-Den Sarira 
Published: July 2023

Abstract
Background
Pharmacists need knowledge and confidence to support people living with mental illness. Evidence-based educational materials for pharmacy students to provide psychosis care is limited.

Aim
To co-design, content validate and pilot-test, with mental health stakeholders, simulated patient scenarios to educate and assess students in providing psychosis care.

Method
Mental health consumers were invited to co-design three simulated patient scenarios (first-episode psychosis, carer of someone living with schizophrenia, non-adherence to antipsychotics), guided by published and psychometrically-tested materials. A panel of mental health stakeholders participated in two rounds of content validation (RAND/UCLA appropriateness model). Round 1 involved individual survey completion to calculate item content validity index (I-CVI) for relevance/clarity, content validity ratio for essentiality and overall scale content validity index (S-CVI/Ave and S-CVI/UA) scores for each scenario. Scores analyses and feedback comments informed revisions. Round 2 involved a panel meeting to discuss revisions and finalise content. The scenarios were then pilot-tested with pharmacy students.

Results
Two consumers participated in co-design, nine stakeholders in content validation. All items showed excellent content validity for relevance/clarity. Eleven items were revised for essentiality, discussed, then re-rated at the panel meeting for consensus. The scenarios were pilot-tested with pharmacy students (n = 15) and reported to be realistic and relevant to future practice, contributing to students’ confidence in supporting people experiencing mental health symptoms or crises.

Conclusion
Partnering with mental health stakeholders has enabled co-design of authentic, content valid educational materials for pharmacy students to provide psychosis care, in preparation for future provision of mental health support.
A two-stage approach for Bayesian joint models: reducing complexity while maintaining accuracy
Authors: Alvares Danilo , Leiva-Yamaguchi Valeria 
Published: July 2023

AbstractSeveral joint models for longitudinal and survival data have been proposed in recent years. In particular, many authors have preferred to employ the Bayesian approach to model more complex structures, make dynamic predictions, or use model averaging. However, Markov chain Monte Carlo methods are computationally very demanding and may suffer convergence problems, especially for complex models with random effects, which is the case for most joint models. These issues can be overcome by estimating the parameters of each submodel separately, leading to a natural reduction in the complexity of the joint modelling, but often producing biased estimates. Hence, we propose a novel two-stage approach that uses the estimations from the longitudinal submodel to specify an informative prior distribution for the random effects when estimating them within the survival submodel. In addition, as a bias correction mechanism, we incorporate the longitudinal likelihood function in the second stage, where its fixed effects are set according to the estimation using only the longitudinal submodel. Based on simulation studies and real applications, we empirically compare our proposal with joint specification and standard two-stage approaches considering different types of longitudinal responses (continuous, count and binary) that share information with a Weibull proportional hazard model. The results show that our estimator is more accurate than its two-stage competitor and as good as jointly estimating all parameters. Moreover, the novel two-stage approach significantly reduces the computational time compared to the joint specification.
Bone Marrow and Wharton’s Jelly Mesenchymal Stromal Cells are Ineffective for Myocardial Repair in an Immunodeficient Rat Model of Chronic Ischemic Cardiomyopathy
Authors: Tang Xian-Liang , Nasr Marjan , Zheng Shirong , Zoubul Taylor , Stephan Jonah K. , Uchida Shizuka , Singhal Richa , Khan Aisha , Gumpert Anna , Bolli Roberto , Wysoczynski Marcin 
Published: July 2023

Abstract
Background
Although cell therapy provides benefits for outcomes of heart failure, the most optimal cell type to be used clinically remains unknown. Most of the cell products used for therapy in humans require in vitro expansion to obtain a suitable number of cells for treatment; however, the clinical background of the donor and limited starting material may result in the impaired proliferative and reparative capacity of the cells expanded in vitro. Wharton’s jelly mesenchymal cells (WJ MSCs) provide a multitude of advantages over adult tissue-derived cell products for therapy. These include large starting tissue material, superior proliferative capacity, and disease-free donors. Thus, WJ MSC if effective would be the most optimal cell source for clinical use.

Objectives
This study evaluated the therapeutic efficacy of Wharton’s jelly (WJ) and bone marrow (BM) mesenchymal stromal cells (MSCs) in chronic ischemic cardiomyopathy in rats.

Methods
Human WJ MSCs and BM MSCs were expanded in vitro, characterized, and evaluated for therapeutic efficacy in a immunodeficient rat model of ischemic cardiomyopathy. Cardiac function was evaluated with hemodynamics and echocardiography. The extent of cardiac fibrosis, hypertrophy, and inflammation was assessed with histological analysis.

Results
In vitro analysis revealed that WJ MSCs and BM MSCs are morphologically and immunophenotypically indistinguishable. Nevertheless, the functional analysis showed that WJ MSCs have a superior proliferative capacity, less senescent phenotype, and distinct transcriptomic profile compared to BM MSC. WJ MSCs and BM MSC injected in rat hearts chronically after MI produced a small, but not significant improvement in heart structure and function. Histological analysis showed no difference in the scar size, collagen content, cardiomyocyte cross-sectional area, and immune cell count.

Conclusions
Human WJ and BM MSC have a small but not significant effect on cardiac structure and function when injected intramyocardially in immunodeficient rats chronically after MI.

Graphical Abstract
Trigonella foenum-graecum L. seed extract modulates biochemical and histomorphological changes in therapeutic model of high-fat diet-fed ovariectomized rats
Authors: Nagamma Takkella , Konuri Anjaneyulu , Bhat Kumar M. R. , Udupa Padmanabha E. G. , Nayak Yogendra 
Published: July 2023

AbstractThis study investigates the therapeutic effect of petroleum ether fraction of Trigonella foenum-graecum L. (PE-TFG) seed extract in ovariectomized rats fed with high-fat diet. Rats were randomly grouped into sham ovariectomy (S.OVX), ovariectomy + high-fat diet (OVX + HFD), and treatment groups. The blood samples were collected, and lipid profile, glucose, hepatic markers, and inflammatory markers were estimated. Liver, kidney, and common carotid artery were isolated for histopathological observations. Liver samples were tested for antioxidant, oxidative stress markers, mRNA expression of adiponectin, and PPAR-γ. PE-TFG treatment significantly decreased total cholesterol (18%), LDL (20%), hepatic markers (28%), leptin (17%), TNF-α (21%), and increased mRNA expression of adiponectin and PPAR-γ. There was also micro- and macro-hepatic steatosis, inflammation in the liver, deteriorated tubules in the kidney, and increased tunica intima and media thickness of the common carotid artery. These pathological alterations were reversed with PE-TFG administration. This impact might be linked to phytoestrogens and other components in PE-TFG such as diosgenin, phenols, and flavonoids.
Microfluidic encapsulation of enzymes and steroids within solid lipid nanoparticles
Authors: Weaver Edward , Sommonte Federica , Hooker Andrew , Denora Nunzio , Uddin Shahid , Lamprou Dimitrios A. 
Published: July 2023

AbstractThe production of solid lipid nanoparticles (SLNs) is challenging, especially when considering the incorporation of biologics. A novel in-house method of microfluidic production of biologic-encapsulated SLNs is proposed, using a variety of base materials for formulation to help overcome the barriers presented during manufacture and administration. Trypsin is used as a model drug for hydrophilic encapsulation whilst testosterone is employed as a positive non-biologic lipophilic control active pharmaceutical ingredient. Particle sizes obtained ranged from 160 to 320 nm, and a lead formulation has been identified from the combinations assayed, allowing for high encapsulation efficiencies (47–90%, respectively) of both the large hydrophilic and the small hydrophobic active pharmaceutical ingredients (APIs). Drug release profiles were analysed in vitro to provide useful insight into sustained kinetics, providing data towards future in vivo studies, which displayed a slow prolonged release for testosterone and a quicker burst release for trypsin. The study represents a large leap forward in the field of SLN production, especially in the field of difficult-to-encapsulate molecules, and the technique also benefits from being more environmentally sustainable due to the use of microfluidics.
Graphical Abstract
$$\ell $$-away ACM bundles on Fano surfaces
Authors: Gawron Filip , Genc Ozhan 
Published: July 2023

AbstractWe propose the definition of $$\ell $$
ℓ
-away ACM bundle on a polarized variety $$(X, {\mathcal O}_{X}(h))$$

(
X
,

O
X

(
h
)

)

. Then we give constructions of $$\ell $$
ℓ
-away ACM bundles on $$({\mathbb {P}^{2}}, {\mathcal O}_{{\mathbb {P}^{2}}}(1))$$

(

P

2

,

O

P

2

(
1
)

)

, $$({\mathbb {P}^{1}} \times {\mathbb {P}^{1}}, {\mathcal O}_{{\mathbb {P}^{1}} \times {\mathbb {P}^{1}}}(1,1))$$

(

P

1

×

P

1

,

O

P

1

×

P

1

(
1
,
1
)

)

and the anticanonically polarized blow up of $${\mathbb {P}^{2}}$$

P

2

up to three non collinear points. Also, we give the complete classification of $$\ell $$
ℓ
-away ACM bundles $${\mathcal E}$$
E
of rank 2 for values $$1 \le \ell \le 2$$

1
≤
ℓ
≤
2

on $$({\mathbb {P}^{2}}, {\mathcal O}_{{\mathbb {P}^{2}}}(1))$$

(

P

2

,

O

P

2

(
1
)

)

. Similarly, on $$({\mathbb {P}^{1}} \times {\mathbb {P}^{1}}, {\mathcal O}_{{\mathbb {P}^{1}} \times {\mathbb {P}^{1}}}(1,1))$$

(

P

1

×

P

1

,

O

P

1

×

P

1

(
1
,
1
)

)

, we give such a classification if $$\textrm{det}({\mathcal E}) = {\mathcal O}_{{\mathbb {P}^{1}} \times {\mathbb {P}^{1}}}(a,a)$$

det

(
E
)

=

O

P

1

×

P

1

(
a
,
a
)

for some $$a \in \mathbb {Z}$$

a
∈
Z

. Moreover, we prove that the corresponding graded module $$\textrm{H}_*^1 ( {\mathcal E}) = {\bigoplus _{t \in \mathbb {Z}}} \textrm{H}^{1} ({\mathcal E}(th))$$

H

∗

1

(
E
)

=

⨁

t
∈
Z

H
1

(
E

(
t
h
)

)

is connected, extending the similar result for bundles on $${\mathbb {P}^{2}}$$

P

2

.
Stroke Experiences and Unmet Needs of Individuals of African Descent Living in High-Income Economy Countries: a Qualitative Meta-Synthesis
Authors: Singh Hardeep , Fakembe Semtetam Patience , Brown Racquel K. , Cameron Jill I. , Nelson Michelle L. A. , Kokorelias Kristina M. , Nekolaichuk Erica , Salbach Nancy M. , Munce Sarah , Tang Terence , Gray Carolyn Steele , Haghayegh Arta Taghavi , Colquhoun Heather 
Published: July 2023

Abstract
Background
Stroke service disparities experienced by individuals of African descent highlight the need to optimize services. While qualitative studies have explored participants’ unique experiences and service needs, a comprehensive synthesis is lacking. To address current knowledge gaps, this review aimed to synthesize existing literature on the experiences of individuals of African descent impacted by a stroke living in high-income economy countries in terms of stroke prevention, management, and care.

Methods
A qualitative meta-synthesis incorporating a meta-study approach was conducted to obtain comprehensive and interpretive insights on the study topic. Four databases were searched to identify qualitative English-language studies published in the year 2022 or earlier on the experiences of adults of African descent who were at risk or impacted by a stroke and living in high-income economy countries. Study methods, theory, and data were analyzed using descriptive and interpretive analyses.

Results
Thirty-seven studies met our inclusion criteria, including 29 journal articles and 8 dissertations. Multiple authors reported recruitment as a key challenge in study conduct. Multiple existing theories and frameworks of health behaviours, beliefs, self-efficacy, race, and family structure informed research positionality, questions, and analysis across studies. Participant experiences were categorized as (1) engagement in stroke prevention activities and responses to stroke symptoms, (2) self-management and self-identity after stroke, and (3) stroke care experiences.

Conclusions
This study synthesizes the experiences and needs of individuals of African descent impacted by stroke. Findings can help tailor stroke interventions across the stroke care continuum, as they suggest the need for intersectional and culturally humble care approaches.
Learning features from irrelevant domains through deep neural network
Authors: Wen Pengcheng , Zhang Yuhan , Wen Guihua 
Published: July 2023

AbstractFeatures of data are much critical to the classification. However, when only small data are available, suitable features can not be easily obtained, easily leading to the bad classification performance. This paper propose a novel approach to automatically learns features from the irrelevant domain with much discriminative features for the given classification task. It first computes as the learning objectives the central vectors of each class in the irrelevant domain, and then uses machine learning method to automatically learn features for each sample in the target domain from these objectives. The merits of our method lie in that unlike the transfer learning, our method does not require the similarity between two domains. It can learn features from much discriminative domains. Its learned features are not limited to its original ones, unlike feature selection and feature extraction methods, so that the classification performance with the learned features can be better. Finally, our method is much general, simple, and efficient. Lots of experimental results validated the proposed method.
A novel three-stage multi-population evolutionary algorithm for constrained multi-objective optimization problems
Authors: Shi Chenli , Wang Ziqi , Jin Xiaohang , Xu Zhengguo , Wang Zhangsheng , Shen Peng 
Published: July 2023

AbstractLots of real-world optimization problems are inherently constrained multi-objective optimization problems (CMOPs), but the existing constrained multi-objective optimization evolutionary algorithms (CMOEAs) often fail to balance convergence and diversity effectively. Therefore, a novel constrained multi-objective optimization evolutionary algorithm based on three-stage multi-population coevolution (CMOEA-TMC) for complex CMOPs is proposed. CMOEA-TMC contains two populations, called mainPop and helpPop, which evolve with and without consideration of constraints, respectively. The proposed algorithm divides the search process into three stages. In the first stage, fast convergence is achieved by transforming the original multi-objective problems into multiple single-objective problems. Coarse-grained parallel evolution of subpopulations in mainPop and guidance information provided by helpPop can facilitate mainPop to quickly approach the Pareto front. In the second stage, the objective function of mainPop changes to the original problem. Coevolution of mainPop and helpPop by sharing offsprings can produce solutions with better diversity. In the third stage, the mining of the global optimal solutions is performed, discarding helpPop to save computational resources. For CMOEA-TMC, the combination of parallel evolution, coevolution, and staging strategy makes it easier for mainPop to converge and maintain good diversity. Experimental results on 33 benchmark CMOPs and a real-world boiler combustion optimization case show that CMOEA-TMC is more competitive than the other five advanced CMOEAs.
Meromorphic functions without real critical values and related braids
Authors: Libgober Anatoly , Shapiro Boris 
Published: July 2023

AbstractWe study the open subset of the Hurwitz space, consisting of meromorphic functions of a given degree defined on closed Riemann surfaces of a given genus and having no real critical values, and enumerate its connected components in terms of braids. Specifically, to a function in this open set, we assign a braid in the braid group of the underlying closed surface and characterize all braids which might appear using this construction. We introduce the equivalence relation among these braids such that the braids corresponding to the meromorphic functions from the same connected component of the above Hurwitz space are equivalent while non-equivalent braids correspond to distinct connected components. Several special families of meromorphic functions, some applications, and further problems are discussed.
Seasonal and diel variations in the acoustic communication of tree hyraxes in Taita Hills, Kenya
Authors: Rosti Hanna , Pihlström Henry , Bearder Simon , Maeda Eduardo , Loehr John , Räsänen Matti , Mwangala Lucas , Maghenda Marianne , Pellikka Petri , Rikkinen Jouko 
Published: July 2023

AbstractTree hyraxes (Dendrohyrax spp.) are highly vocal, elusive nocturnal mammals that live in forests across much of Sub-Saharan Africa. Here, we studied how tree hyrax acoustic communication activity varies during the year in a moist montane forest in Taita Hills, Kenya. Our study increases the knowledge about the seasonal and diel variation in tree hyrax calling activity and on the impact of exogenous factors on the calling behavior of the species. A group of tree hyraxes called 700–2000 times during the night, and calling rate was highest during dry season months. Calling activity was bimodal, with peaks between 19.00 and 20.00 h in the evening and between 04.00 and 05.00 h in the morning; however, counter-calling bouts occurred throughout the night. Singing peaked in May, possibly coinciding with the species’ mating season. Calling activity decreased during full moon phases, probably because the animals felt vulnerable to predation. Tree hyrax calling was suppressed by rain, as rainfall is a powerful acoustic competitor. Annual changes in night temperature, the background chorus of vocalizing orthopterans, or the competing calls of nocturnal primates did not reduce tree hyrax calling rates. The latter suggests that sympatric nocturnal mammals have adapted to each other’s calls as an intrinsic feature of the soundscape of their forest habitat.
Integrating community voices in the research continuum: Perspectives on a consultation service
Authors: Evans Crystal D. , Nanda Joy P. , Ouyang Pamela , Bone Lee , Byiringiro Samuel , Lacanienta Cyd , Clark Roger , Weston Christine , Han Hae-Ra , Terkowitz Mia , Bates-Hopkins Barbara , Galiatsatos Panagis , Xu Ashley Jingzhi , Stevens Sarah , Himmelfarb Cheryl R. 
Published: July 2023

Abstract
The Community Research Advisory Council (C-RAC) of the Johns Hopkins Institute for Clinical and Translational Research was established in 2009 to provide community-engaged research consultation services. In 2016–2017, C-RAC members and researchers were surveyed on their consultation experiences. Survey results and a 2019 stakeholder meeting proceeding helped redesign the consultation services. Transitioning to virtual consultations during COVID-19, the redesigning involved increasing visibility, providing consultation materials in advance, expanding member training, and effective communications. An increase in consultations from 28 (2009–2017) to 114 (2020–2022) was observed. Implementing stakeholder-researcher inputs is critical to holistic and sustained community-engaged research.