bluuebunny/crossref_metadata_2025_split huggingface dataset:
HPLC-based metabolomics of Dendrobium officinale revealing its antioxidant ability
Authors: Luo Zhengfei , Liu Lian , Nie Qiong , Huang Mingjin , Luo Chunlii , Sun Yedong , Ma Yongyan , Yu Jianxin , Du Fuqiang 
Published: January 2023

Dendrobium officinale is an orchid with medicinal and nutritional properties that has received increasing attention because of its health benefits; however, there is limited information about the metabolic basis of these properties. In this report, secondary metabolites and the antioxidant activity of D. officinale stem samples from three provenances were analyzed, using a UHPLC-QqQ-MS/MS-based metabolomics approach. In total, 411 metabolites were identified including 8 categories such as flavonoids and phenolic acids, 136 of which were differential metabolites. These differentially accumulated metabolites (DAMs) were mainly enriched in secondary metabolic pathways such as flavone, flavonol, tropane, piperidine, pyridine, isoquinoline alkaloid biosynthesis and tyrosine metabolism. The metabolomic profiling suggested that the quantity and content of flavonoid compounds accounted for the highest proportion of total metabolites. Hierarchical cluster analysis (HCA) showed that the marker metabolites of D. officinale from the three provenances were mainly flavonoids, alkaloids and phenolic acids. Correlation analysis identified that 48 differential metabolites showed a significant positive correlation with antioxidant capacity (r ³ 0.8 and p &lt; 0.0092), and flavonoids were the main factors affecting the different antioxidant activities. It is worth noting that quercetin-3-O-sophoroside-7-O-rhamnoside and dihydropinosylvin methyl ether might be the main compounds causing the differences in antioxidant capacity of Yunnan provenance (YN), Zhejiang provenance (ZJ), and Guizhou provenance (GZ). These finding provides valuable information for screening varieties, quality control and product development of D. officinale.
Loneliness and disability: A systematic review of loneliness conceptualization and intervention strategies
Authors: Gómez-Zúñiga Beni , Pousada Modesta , Armayones Manuel 
Published: January 2023

IntroductionPeople with disabilities experience loneliness to a greater extent than people without disabilities. To better understand this problem, we have conducted a systematic review of studies that involved disability and loneliness. The aims are to research what loneliness is and to conceptualize and define it in the context of disability, and the intervention strategies that have been developed.MethodsThe research protocol is based on the PRISMA guidelines. Two hundred and eighty-one papers were screened and 75 reports were assessed for eligibility.ResultsWe have not found whether loneliness in disability is a single construct or a collection of various subtypes. We have found that there are protective factors against loneliness in disabled people, such as having a job or living in an environment without physical barriers.DiscussionIn terms of the interventions for people with disabilities, the same strategies have been adopted as for the non-disabled: social skills training, enhanced social support, opportunities for interactions, and cognitive training.
Aberrant neural correlates of multisensory processing of audiovisual social cues related to social anxiety: An electrophysiological study
Authors: Gan Shuzhen , Li Weijun 
Published: January 2023

BackgroundSocial anxiety disorder (SAD) is characterized by abnormal fear to social cues. Although unisensory processing to social stimuli associated with social anxiety (SA) has been well described, how multisensory processing relates to SA is still open to clarification. Using electroencephalography (EEG) measurement, we investigated the neural correlates of multisensory processing and related temporal dynamics in social anxiety disorder (SAD).MethodsTwenty-five SAD participants and 23 healthy control (HC) participants were presented with angry and neutral faces, voices and their combinations with congruent emotions and they completed an emotional categorization task.ResultsWe found that face-voice combinations facilitated auditory processing in multiple stages indicated by the acceleration of auditory N1 latency, attenuation of auditory N1 and P250 amplitudes, and decrease of theta power. In addition, bimodal inputs elicited cross-modal integrative activity which is indicated by the enhancement of visual P1, N170, and P3/LPP amplitudes and superadditive response of P1 and P3/LPP. More importantly, excessively greater integrative activity (at P3/LPP amplitude) was found in SAD participants, and this abnormal integrative activity in both early and late temporal stages was related to the larger interpretation bias of miscategorizing neutral face-voice combinations as angry.ConclusionThe study revealed that neural correlates of multisensory processing was aberrant in SAD and it was related to the interpretation bias to multimodal social cues in multiple processing stages. Our findings suggest that deficit in multisensory processing might be an important factor in the psychopathology of SA.
Exploitation of a shared genetic signature between obesity and endometrioid endometrial cancer
Authors: Duan Junyi , Yi Jiahong , Wang Yun 
Published: January 2023

AimsThe findings in epidemiological studies suggest that endometrioid endometrial cancer (EEC) is associated with obesity. However, evidence from gene expression data for the relationship between the two is still lacking. The purpose of this study was to explore the merits of establishing an obesity-related genes (ORGs) signature in the treatment and the prognostic assessment of EEC.MethodsMicroarray data from GSE112307 were utilized to identify ORGs by using weighted gene co-expression network analysis. Based on the sequencing data from TCGA, we established the prognostic ORGs signature, confirmed its value as an independent risk factor, and constructed a nomogram. We further investigated the association between grouping based on ORGs signature and clinicopathological characteristics, immune infiltration, tumor mutation burden and drug sensitivity.ResultsA total of 10 ORGs were identified as key genes for the construction of the signature. According to the ORGs score computed from the signature, EEC patients were divided into high and low-scoring groups. Overall survival (OS) was shorter in EEC patients in the high-scoring group compared with the low-scoring group (P &lt; 0.001). The results of the Cox regression analysis showed that ORGs score was an independent risk factor for OS in EEC patients (HR = 1.017, 95% confidence interval = 1.011–1.023; P &lt; 0.001). We further revealed significant disparities between scoring groups in terms of clinical characteristics, tumor immune cell infiltration, and tumor mutation burden. Patients in the low-scoring group may be potential beneficiaries of immunotherapy and targeted therapies.ConclusionsThe ORGs signature established in this study has promising prognostic predictive power and may be a useful tool for the selection of EEC patients who benefit from immunotherapy and targeted therapies.
Design, Synthesis and Structure-Activity Relationship Studies of Nicotinamide Derivatives as Potent Antifungal Agents by Disrupting Cell Wall
Authors: Ni Tingjunhong , Xie Fei , Li Liping , Hao Yumeng , Chi Xiaochen , Yan Lan , Zhang Dazhi , Jiang Yuanying , Lv Quanzhen 
Published: January 2023

Fungal infections pose a serious challenge to human health due to the limited paucity of antifungal treatments. Starting as a hit compound screened from our compound library, a series of nicotinamide derivatives have been successfully synthesized via a facile one-step coupling reaction of aromatic carboxylic acid and amine. The synthesized compounds were evaluated for their antifungal activity against Candida albicans SC5314. Among the 37 nicotinamide derivatives screened, compound 16g was found to be the most active against C. albicans SC5314, with an MIC value of 0.25 μg/mL and without significant cytotoxicity. The rudimentary structure-activity relationships study revealed that the position of the amino and isopropyl groups of 16g was critical for its antifungal activity. In particular, compound 16g showed potent activity against six fluconazole-resistant C. albicans strains with MIC values ranging from 0.125–1 μg/mL and showed moderate activity against the other seven species of Candida, three strains of Cryptococcus neoformans, and three strains of Trichophyton. Furthermore, compound 16g showed fungicidal, anti-hyphal, and anti-biofilm activities in vitro, which were related to its ability to disrupt the cell wall of C. albicans. Taken together, 16g is a promising compound that is fungal-specific by targeting the cell wall and could be used as a lead compound for further investigation.
Manejo nutricional e comportamental de filhotes de Cachorro- do- mato Cerdocyon thous mantidos para reabilitação em cativeiro na Fazenda Palmares no município de Santa Cruz das Palmeiras, SP, Brasil
Authors: Angelotti Isabella Benedeti , Santos Andressa Satiko Watanabe , Nakamae Henrique Hitoshi de Moraes , Jardim Felipe Cardoso , De Lima Tatiane Gonçalves , Duemes Jéssica , F. Passos Rodrigo Rabello de F. C. e , Lopes Edris Queiroz 
Published: January 2023

O cachorro- do- mato ou lobinho, raposa, graxaim- do- mato ou lobete é uma espécie onívora com hábitos noturnos e costumam caçar em duplas, onde dificilmente são encontrados grupos dos mesmos, apenas pequenas famílias. Sua distribuição geográfica é dispersa por todo o território da América do Sul, excluindo áreas como a Floresta Amazônica. Estão acostumados a diversos biomas, incluindo locais próximos às habitações humanas, o que muitas vezes ocasiona em caças ilegais, morte ou traumas por máquinas agrícolas e o contato iminente com o homem. Este estudo tem como objetivo relatar a reabilitação em cativeiro, baseado na história de dois cachorros- do- mato encontrados em um canavial na cidade de Leme, interior do estado de São Paulo, logo após terem sido atropelados por uma máquina agrícola durante o processo de extração da cana-de-açúcar. O Estudo foi realizado no Núcleo de Pesquisas do IBIMM, onde fez-se uso de técnicas de enriquecimento ambiental e metodologias já aplicadas em outros casos parecidos. Apontou-se que a reabilitação foi um sucesso, com os animais capacitados ao convívio normal dentro do cativeiro e sem apresentar sequelas. Revela-se que um enriquecimento bem planejado, elaborado e seguido com precisão, faz a diferença para a vida e bem estar dos animais silvestres que precisam superar o estresse do cativeiro.
The Four Social Groups that Predominated the Sangam Era
Authors: M Kalivani , V.A Palaniyappan 
Published: January 2023

All the relationships that man takes do not become social relationships. Social relationship occurs when one person. Perceives the presence of another person. Social relationships arise from the destruction something between two or more people. Such social relationships create society. Wherever social relationships are found there is a life of society. Wherever social relationship is found there is a life of society. Through sociology study, one can clearly understand how a society came into being, how it is structured, how it can get rid of defects imposed on the human being in the way of upbringing and provide a perspective that elevates human life to a higher level. Ability can also be developed history of social life associated problems are as old as society in the early days of human civilization, we call society the complex social relationship of living together with others. This study traces the graduate development of a species or group into a cultured one. This Article is to mention four types of Society and fall how this society came into being.
STUDENTS’ DIFFICULTIES IN LEARNING PRONUNCIATION: A CASE STUDY OF SMP ISLAM TERPADU DHUAFA MERANGIN STUDENTS IN LEARNING ENGLISH
Authors: Andriani Diyan 
Published: January 2023

This study reveals about students’ difficulties in English pronunciation experienced by learners whose first language is Indonesia language. The subjects of this study were the seventh grade of students at SMP Islam Terpadu Dhuafa Merangin especially class B. They were males. The instruments of this study were task, interview and recording. In analyzing the data, the researcher used descriptively and statistically. The findings of this study showed that the students had problems in pronunciation because of their had low motivation, exposure and their attitude in learning English pronunciation. It could be seen from the result of the task when the researcher asked them to pronunce the English words and the result of interview.
Right internal mammary artery for the management of anomalous right coronary artery from the left sinus of Valsalva; a case report
Authors: Alshehri Abdullah , Alotaibi Khaled , Alawami Mortadha , Pragliola Claudio 
Published: January 2023

Background: Anomalous origin of the right coronary artery from the left sinus of Valsalva (ARCA) is a rare anomaly. Surgery is recommended in symptomatic patients, while the optimal surgical approach is controversial.
Case presentation: We present a case of an ARCA in a 56-year-old male who was managed with coronary artery bypass grafting using the right internal mammary artery and ligation of the proximal right coronary artery. The patient remained asymptomatic after 1 year of follow-up.
Conclusions: ARCA can be managed using the right internal mammary artery with ligation of the proximal right coronary artery to prevent the competitive flow.
Development and validation of comprehensive closed formulas for atmospheric delay and altimetry correction in ground-based GNSS-R
Authors: Nikolaidou Thalia , Santos Marcelo , Williams Simon , Geremia-Nievinski Felipe 
Published: January 2023

<p> Radio wave propagation involved in Global Navigation Satellite System Reflectometry (GNSS-R) is subject to atmospheric refraction. Even for ground-based tracking stations, in applications such as coastal sea-level altimetry, the interferometric or reflection-minus-direct effect might be significant. Although atmospheric propagation delays are best investigated numerically via raytracing, including reflections, such a procedure is not trivial. We have developed simpler closed formulas to account for atmospheric refraction in ground-based GNSS-R, validated against independent raytracing. We provide specific expressions for the two components of the atmospheric interferometric delay and corresponding altimetry correction components, parameterized in terms of refractivity and bending angle. Assessment results showed excellent agreement for both components. We define the interferometric slant factor used to map interferometric zenithal delays to individual satellites.</p>
Quantization: Is It Possible to Improve Classification?
Authors: lu weizhi , Chen Mingrui , guo kai , Li Weiyu 
Published: January 2023

<p> Large-scale classification poses great challenges to storage and computation. There are two major solutions to address the problem: data compression and quantization. In the paper, we study the method of first reducing data dimension by random projection and then quantizing the projections to ternary and binary codes, which has been widely applied in practice. Often, the extreme quantization would degrade the accuracy of classification due to high quantization errors. Interestingly, however, we observe that the quantization could result in performance improvement, rather than degradation, if the data for quantization are preprocessed by sparse transform. Also, the quantization gain could be obtained with the random projections of the data, if both the data and random projection matrices are sparse enough, such that the resulting projections remain sparse. The intriguing performance is verified and analyzed with extensive experiments.<br>
</p>
RIS-Based Steerable Beamforming Antenna with Near-Field Eigenmode Feeder
Authors: Tiwari Krishan Kumar , Caire Giuseppe 
Published: January 2023

We present a novel, power and hardware efficient, antenna system
leveraging the eigenmodes of the over-the-air propagation matrix from an
active multi-antenna feeder (AMAF) to a large reflective intelligent
surface (RIS), both configured as standard linear arrays and placed in
the near field of each other. We demonstrate the flexibility of the
proposed architecture by showing that it is capable of generating
radiation patterns for multiple applications such as very narrow beams
with low side lobes for space-division multiple access communications,
wide-angle beams for short range automotive sensing and sectorial
beaconing, and monopulse-like patterns for radar angular tracking. A key
parameter in our design is the AMAF-RIS distance which must be optimized
and it is generally much less than the Rayleigh distance. For a given
AMAF aperture, the optimal AMAF-RIS distance increases as a function of
the RIS size. The AMAF-RIS loss is compensated almost exactly by the
larger aperture gain of the RIS leading to almost constant RIS gain with
increasing RIS sizes. This allows to choose different beam angular
selectivities with the same center beam gain. Active RF amplification is
done at the AMAF only, thus resulting in a much higher power efficiency
and much lower hardware complexity than conventional phased arrays with
same beamforming performance.
Accepted for the IEEE ICC 2023, Rome
On modules over the mod 2 Steenrod algebra and hit problems
Authors: Võ Phúc Đặng 
Published: January 2023

<p>Let us consider the prime field of two elements, $\mathbb F_2\equiv \mathbb Z_2.$ It is well-known that the classical "hit problem" for a module over the mod 2 Steenrod algebra $\mathscr A$ is an interesting and important open problem of Algebraic topology, which asks a minimal set of generators for the polynomial algebra $\mathcal P_m:=\mathbb F_2[x_1, x_2, \ldots, x_m]$ on $m$ variables $x_1, \ldots, x_m,$ each of degree one, regarded as a connected unstable $\mathscr A$-module. The algebra $\mathcal P_m$ is the cohomology with $\mathbb F_2$-coefficients of the product of $m$ copies of the Eilenberg-MacLan complex $K(\mathbb F_2, 1).$ Although the hit problem has been thoroughly studied for more than 3 decades, solving it remains a mystery for any $m\geq 5.$ In this article, we develop our previous work [Commun. Korean Math. Soc. 35 (2020), 371-399] on the hit problem for $\mathscr A$-module $\mathcal P_5$ in generic degree $n:=n_s = 5(2^{s}-1) + 18.2^{s}$ with $s$ an arbitrary non-negative integer. As an immediate consequence, a local version of Kameko's conjecture for the dimension of the cohit space $\mathbb F_2\otimes_{\mathscr A}\mathcal P_m$ associated with weight vectors is true for $m = 5$ and degree $n_s.$ Also, we show that this conjecture also holds for any $m\geq 1$ and degrees $\leq 12.$ Two applications of this study are to establish the dimension result for the cohit space $\mathbb F_2\otimes_{\mathscr A}\mathcal P_m$ for $m = 6$ in generic degree $5(2^{s+4}-1) + n_1.2^{s+4}$ with $s > 0$ and to describe the modular representations of the general linear group of rank $5$ over $\mathbb F_2.$ Our results then show that the algebraic transfer, defined by W. Singer [Math. Z. 202 (1989), 493-523], is an isomorphism in bidegrees $(5, 5+n_s)$ with $s\geq 0.$ Also, we prove that Singer's transfer is a trivial isomorphism in bidegree $(m, m+12)$ with $m$ an arbitrary positive integer.</p>
Digital Health and Machine Learning Technologies for Blood Glucose Monitoring and Management of Gestational Diabetes
Authors: Lu Huiqi , Ding Xiaorong , Hirst Jane E , Yang Yang , Yang Jenny , MacKillop Lucy , Clifton David A. 
Published: January 2023

<p><em>Abstract</em>— Innovations in digital health and machine learning are changing the path of clinical health and care. People from many different geographies and cultures can benefit from the mobility of wearable devices and smartphones to monitor their health in a ubiquitous manner. This paper focuses on reviewing the digital health and machine learning technologies used in gestational diabetes ̶ a subtype of diabetes that occurs during pregnancy. Despite a large number of patients with gestational diabetes, only a handful of digital health applications have been deployed in clinical practice. This paper reviews sensor technologies in blood glucose monitoring devices and machine learning fused digital health innovations for gestational diabetes monitoring and management in both clinical and commercial settings. It is one of the first comprehensive reviews in this area to the best of our knowledge. In conclusion, there is a need to (1) develop digital health technologies and clinically interpretable machine learning methods for patients with gestational diabetes, assisting health professionals with treatment monitoring and planning; (2) adapt and develop clinically proven devices for patient self-management of health and well-being at the hospital and home settings thereby facilitating timely intervention; and (3) ensure innovations are affordable and sustainable for women everywhere.</p>
<p>Data statement: this is a review manuscript that have not generated any new data.</p>
<p>The views expressed are those of the authors and not necessarily those of InnoHK. This research was supported by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.</p>
Universal Joint Source-Channel Coding Under an Input Energy Constraint
Authors: Lev Omri , Khina Anatoly 
Published: January 2023

<p>We consider the problem of transmitting a source over an infinite-bandwidth additive white Gaussian noise channel with unknown noise level under an input energy constraint. We construct a universal scheme that uses modulo-lattice modulation with multiple layers; for each layer, we employ either analog linear modulation or analog pulse position modulation (PPM). We show that the designed scheme with linear layers requires less energy compared to existing solutions to achieve the same quadratically increasing distortion profile with the noise level; replacing the linear layers with PPM layers offers an additional improvement. </p>