bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue
Authors: Nottmeier Cita , Lavicky Josef , Gonzalez Lopez Marcos , Knauth Sarah , Kahl-Nieke Bärbel , Amling Michael , Schinke Thorsten , Helms Jill , Krivanek Jan , Koehne Till , Petersen Julian 
Published: June 2023

AbstractMechanosensory ion channels are proteins that are sensitive to mechanical forces. They are found in tissues throughout the body and play an important role in bone remodeling by sensing changes in mechanical stress and transmitting signals to bone-forming cells. Orthodontic tooth movement (OTM) is a prime example of mechanically induced bone remodeling. However, the cell-specific role of the ion channels Piezo1 and Piezo2 in OTM has not been investigated yet. Here we first identify the expression of PIEZO1/2 in the dentoalveolar hard tissues. Results showed that PIEZO1 was expressed in odontoblasts, osteoblasts, and osteocytes, while PIEZO2 was localized in odontoblasts and cementoblasts. We therefore used a Piezo1floxed/floxed mouse model in combination with Dmp1cre to inactivate Piezo1 in mature osteoblasts/cementoblasts, osteocytes/cementocytes, and odontoblasts. Inactivation of Piezo1 in these cells did not affect the overall morphology of the skull but caused significant bone loss in the craniofacial skeleton. Histological analysis revealed a significantly increased number of osteoclasts in Piezo1floxed/floxed;Dmp1cre mice, while osteoblasts were not affected. Despite this increased number of osteoclasts, orthodontic tooth movement was not altered in these mice. Our results suggest that despite Piezo1 being crucial for osteoclast function, it may be dispensable for mechanical sensing of bone remodeling.
Long-term behavioral effects of social separation during early life in a social mammal, Octodon degus
Authors: Ukyo Rina , Shinohara Akio , Koshimoto Chihiro , Nagura-Kato Goro A. , Ieiri Seiji , Tsuzuki Yasuhiro , Sakamoto Shinsuke H. 
Published: June 2023

AbstractSocial separation is thought to induce a strong stress response in social juvenile mammals, but little is known about how this response might vary throughout the development. The present study examines the long-term effects of early-life stress (ELS) induced by social separation on individual behaviors later in life using the social and precocious species Octodon degus. Four experimental groups were established a positive control group of mothers and siblings from six litters comprised the socially housed (SH) group, while pups from seven litters were randomly assigned to three treatments: pups experiencing no separation (NS) treatment while their siblings did; repeated bouts of consecutive separation (CS); intermittent separation (IS). We analyzed the effects of separation treatment on the frequency and duration of freezing, rearing and grooming behaviors. ELS was correlated with higher hyperactivity, and hyperactivity increased with more frequent separation. However, the behavioral trend of the NS group changed to hyperactive in long-term observation. The findings suggest that the NS group was indirectly affected by ELS. In addition, suggesting ELS acts to converge an individual’s behavioral tendencies in a certain direction.
Flexible operation of a CHP‐VPP considering the coordination of supply and demand based on a strengthened distributionally robust optimization
Authors: Yu Songyuan , Fang Fang , Liu Jizhen 
Published: June 2023

AbstractDue to the generation variability, the growing capacity of renewable energy has posed unprecedented challenges to ensure the security of power system operation. Here, a two‐stage strengthened distributionally robust optimization (DRO) scheme is proposed for theself‐scheduling of a combined heat and power virtual power plant (CHP‐VPP) over a coupled electric power network (EPN) and district heating network (DHN). The CHP‐VPP operator maximizes its profits in the day‐ahead market and minimizes its cost in the real‐time market under the worst‐case realization of the uncertainties. Instead of assuming that the uncertainties follow known probability distributions or confidence bounds, a strengthened ambiguity set based on moment information and Wasserstein metric is built to provide more accurate characterizations of the true probability distribution of uncertainties. In addition, in order to enhance the flexibility of the system, a HOMIE model considering indoor activities and outside temperatures of each building is built to satisfy the comfortable indoor temperature. To make the whole problem tractable, linearisation and duality theory are adopted, and then a tailored column‐and‐constraint generation algorithm is developed to solve the problem. The validity and applicability of the strengthened DRO scheme are verified by an IEEE 33‐bus EPN and 14‐node DHN.
Supply‐demand optimizer for economic emission dispatch incorporating price penalty factor and variable load demand levels
Authors: Hassan Mohamed H. , Kamel Salah , Shaikh Muhammad Suhail , Alquthami Thamer , Hussien Abdelazim G. 
Published: June 2023

AbstractThe Economic and Emission Dispatch (EED) method is widely used to optimize generator output in a power system. The goal is to reduce fuel costs and emissions, including carbon dioxide, sulphur dioxide, and nitrogen oxides, while maintaining power balance and adhering to limit constraints. EED aims to minimize emissions and operating costs while meeting power demands. To solve the multi‐objective EED problem, the supply‐demand optimization (SDO) algorithm is proposed, which employs a price penalty factor approach to convert it into a single‐objective function. The SDO algorithm uses a swarm‐based optimization strategy inspired by supply‐demand mechanisms in economics. The algorithm's performance is evaluated on seven benchmark functions before being used to simulate the EED problem on power systems with varying numbers of units and load demands. Established algorithms like the Grey Wolf Optimizer (GWO), Moth‐Flame Optimization (MFO), Transient Search Optimization (TSO), and Whale Optimization Algorithm (WOA) are compared to the SDO algorithm. The simulations are conducted on power systems with different numbers of units and load demands to optimize power generation output. The numerical analyses demonstrate that the SDO technique is more efficient and produces higher quality solutions than other recent optimization methods.
Oblique rings from migrating exomoons: A possible origin for long-period exoplanets with enlarged radii
Authors: Saillenfest Melaine , Sulis Sophia , Charpentier Paul , Santerne Alexandre 
Published: June 2023

Context. The extremely low density of several long-period exoplanets in mature systems is still unexplained - with HIP 41378 f being archetypical of this category. It has been proposed that such planets could actually have normal densities but be surrounded by a ring observed approximately face on, mimicking the transit depth of a puffy planet. This configuration would imply that the equator of the planet is nearly perpendicular to its orbit plane, which is at odds with the formation process of gas giants. Yet, in the context of the Solar System planets, it has recently been shown that after gigayears of evolution, the tidal migration of a moon can naturally lead to a very tilted planet with a ring.
Aims. As exomoons are expected to be ubiquitous around giant exoplanets, this mechanism may be responsible for the anomalous radii of some observed exoplanets. In preparation for the future discoveries of the PLATO mission, we present a simple method for checking the plausibility of this mechanism for a given exoplanet.
Methods. Analytical formulas give the probability density function of the relevant precession harmonics of the planet. For each harmonic, simple criteria set the moon mass and other properties required for the mechanism to operate.
Results. We applied this methodology to HIP 41378 f, and we show that in order to reproduce the observed configuration, a hypothetical former moon should have had a moon-to-planet mass ratio of a few times 10−4 (i.e. roughly the mass of our Moon) and have migrated over a distance of a few planet’s radii on a gigayear timescale. These orders of magnitude match the properties of moons expected to exist around gaseous exoplanets.
Conclusions. We conclude that the migration of a former moon is a viable formation pathway for the proposed ring and tilt of HIP 41378 f. This example strengthens the ring hypothesis and motivates its application to other promising targets.
Tibial tubercule osteotomy during the revision of total knee arthroplasty: The technique of a referral center with 10 years of experience
Authors: Cance Nicolas , Batailler Cecile , Canetti Robin , Servien Elvire , Lustig Sébastien 
Published: June 2023

Introduction: The Tibial Tubercle Osteotomy (TTO) technique, by lifting the distal bony attachment of the extensor mechanism, allows efficient knee exposure while preserving soft tissues and tendinous attachments. The surgical technique seems essential to obtain satisfying outcomes with a low rate of specific complications. Several tip sand tricks can be used to improve this procedure during the revision of total knee arthroplasty (RTKA). Technique: The osteotomy should be at least: 60 mm in length and 20 mm in width to allow fixation with 2 screws; and 10–15 mm thick to resist to screw compression. The proximal cut of the osteotomy must keep a proximal buttress spur of 10 mm to get primary stability and avoid the tubercle ascension. A smooth end of the TTO distally reduces the risk of a tibial shaft fracture. The strongest fixation is obtained using two bicortical 4.5 mm screws slightly ascendant. Results: From January 2010 to September 2020, 135 patients received an RTKA with concomitant TTO and a mean follow-up of 51 ± 26 months [24–121]. The osteotomy was healed in 95% of patients (n = 128) with a mean delay of 3.4 ± 2.7 months [1.5–24]. However, there are some specific and significant complications related to the TTO. Twenty complications (15%) related to the TTO were recorded, with 8 (6%) requiring surgery. Conclusion: Tibial tubercle osteotomy in RTKA is an efficient procedure to improve knee exposure. To avoid tibial tubercle fracture or non-union, a rigorous surgical technique is primordial with a sufficient length and thickness of the tibial tubercle, a smooth end, a proximal step, a final good bone contact, and a strong fixation.
Insulin Secretion Capacity as a Crucial Feature to Distinguish Type 1
From Type 2 Diabetes and to Indicate the Need for Insulin Therapy – A
Critical Discussion of the ADA/EASD Consensus Statement on the
Management of Type 1 Diabetes in Adults
Authors: Fritsche Andreas 
Published: June 2023

AbstractIn the recently published consensus statement on the treatment and management of
type 1 diabetes issued by experts from the American (ADA) and European (EASD)
diabetes societies, measurement of endogenous insulin secretion using fasting
C-peptide is recommended as a diagnostic criterion. In contrast, our group
recently suggested fasting C-peptide/glucose ratio (CGR) for the
determination of endogenous insulin secretion. In addition, this ratio may turn
out as a potential decision aid for pathophysiologically based differential
therapy of diabetes. In this comment, the following points will be discussed: i)
CGR as the basis of differential diagnosis of type 1 diabetes, ii) CGR as the
basis of treatment decisions for or against insulin in diabetes, and iii) the
ease of application of CGR in clinical practice. The use of CGR may complement
the ADA/EASD recommendations and should provide a practical application
in clinical practice.
AGE RAGE Pathways: Cardiovascular Disease and Oxidative
Stress
Authors: Sharma Neeraj , Kumar Pavan , Shukla Karuna Shanker , Maheshwari Shubhrat 
Published: June 2023

AbstractIt is well established that Advanced Glycation End Products (AGEs) and their
receptor (RAGE) are primarily responsible for the development of cardiovascular
disease. As a result, diabetic therapy is very interested in therapeutic
strategies that can target the AGE-RAGE axis. The majority of the AGE-RAGE
inhibitors showed encouraging outcomes in animal experiments, but more
information is needed to completely understand their clinical effects. The main
mechanism implicated in the aetiology of cardiovascular disease in people with
diabetes is oxidative stress and inflammation mediated by AGE-RAGE interaction.
Numerous PPAR-agonists have demonstrated favourable outcomes in the treatment of
cardio-metabolic illness situations by inhibiting the AGE-RAGE axis. The
body’s ubiquitous phenomena of inflammation occur in reaction to
environmental stressors such tissue damage, infection by pathogens, or exposure
to toxic substances. Rubor (redness), calor (heat), tumour (swelling), colour
(pain), and in severe cases, loss of function, are its cardinal symptoms. When
exposed, the lungs develop silicotic granulomas with the synthesis of collagen
and reticulin fibres. A natural flavonoid called chyrsin has been found to have
PPAR-agonist activity as well as antioxidant and anti-inflammatory properties.
The RPE insod2+/animals underwent mononuclear phagocyte-induced
apoptosis, which was accompanied with decreased superoxide dismutase 2 (SOD2)
and increased superoxide generation. Injections of the serine proteinase
inhibitor SERPINA3K decreased proinflammatory factor expression in mice with
oxygen-induced retinopathy, decreased ROS production, and increased levels of
SOD and GSH.
Qualitätssicherung in der psychiatrischen Versorgung: Ein
standardisierter Behandlungsprozess für die Medizinisch Therapeutischen
Dienste der Universitären Psychiatrischen Kliniken Basel
Authors: Hug Niki , Neyenhuys Annetta , Nienaber André 
Published: June 2023

Zusammenfassung
Ziel Für die Medizinisch Therapeutischen Dienste (MTD) wurde an
den Universitären Psychiatrischen Kliniken Basel (UPK) im Rahmen eines
Qualitätsentwicklungsprojektes der Behandlungsprozess standardisiert.
Ziel war es die bestehenden, heterogenen Strukturen und Prozesse der
unterschiedlichen Fachtherapien inklusive deren Therapieinhalte, Methoden und
Dokumentationsverfahren auf interne und externe Evidenz zu prüfen,
Transparenz zu schaffen, sie wo möglich zu standardisieren und die
Effektivität und Effizienz zu erhöhen.
Methoden In der Ist-Analyse erfolgte eine Literaturrecherche zu
Wirksamkeitsstudien, Leitlinien, Assessments und Indikationsstellungen der
Therapien. Zusätzlich wurden systematisch Leistungs- und
Personalkennzahlen der MTD ermittelt. Die darauf gestützte
SOLL-Definition erfolgte durch ein iteratives Projektvorgehen. Dabei wurden in
einer Arbeitsgruppe bestehende Inhalte aus der IST-Analyse zusammengetragen und
laufend in offenen und explorativen Verfahren (Brainstorming, Mindmapping)
weiterverarbeitet und zur Erarbeitung von Kriterien, Bewertungen, Abbildung von
Prozessabläufen und Strukturvorgaben verwendet. Daraus sind letztlich
verschiedene Massnahmepakete entstanden.
Ergebnis Aus dem Projekt ging eine umfassende Überarbeitung des
Therapienangebotes, Kernkonzepte der Angebote und eine Schärfung der
Indikationen hervor. Daneben wurde ein Gesamtprozess für den MTD
definiert, Checklisten und Musterstellenbeschreibungen erarbeitet, neue
Funktionen eingeführt (Verantwortliche Berufsbildung) sowie eine fixe
Zuteilung der Mitarbeitenden zu sämtlichen Abteilungen festgelegt. Mit
der Einführung der Internationalen Klassifikation der
Funktionsfähigkeit, Behinderung und Gesundheit (ICF) konnte eine
einheitliche Grundlage geschaffen werden in Bezug auf die Diagnostik, die
Interventionsplanung und die Dokumentation.
Schlussfolgerung Der vorliegende Praxisbericht zeigt auf, wie
evidenzbasierte Versorgung aus der Sicht der Medizinisch Therapeutischen Dienste
im Hinblick auf die stationäre psychiatrische Behandlung umgesetzt
werden kann, welche Effekte dadurch erhofft werden und welche Herausforderungen
damit verbunden sind. Das Projekt zur Qualitätssicherung mittels
Standardisierung bietet Klarheit und Transparenz für alle Berufsgruppen
im Behandlungsprozess. Patient*innen wird insbesondere durch eine
verbesserte Indikation und Diagnostik eine effektivere und individalisierte
Behandlung ermöglicht.
Digitale Volumentomografie bei der Behandlung von
Radiusfrakturen
Authors: Wieschollek Stefanie , Knie Careen , Megerle Kai 
Published: June 2023

ZusammenfassungDie digitale Volumentomografie (DVT) bietet in der Handchirurgie eine relativ
neue Form der Schnittbildgebung. Die distale Radiusfraktur nimmt als
häufigste Fraktur des Erwachsenen einen besonderen Stellenwert ein,
nicht nur für Handchirurgen. Das Patientenaufkommen ist hoch und es
bedarf schneller und valider Diagnostik. Operative Techniken und
Möglichkeiten werden stetig weiterentwickelt, insbesondere was
intraartikuläre Frakturen betrifft. Der Anspruch auf exakte Versorgung
ist hoch. Bei der Indikation einer präoperativen dreidimensionalen
Bildgebung besteht weitestgehend Einigkeit und sie findet häufig
Anwendung. Üblicherweise erfolgt sie mittels Mehrzeilen-Spiral-CT
(Multidetektor-CT, MDCT). Die postoperative Bildgebung beschränkt sich
in den meisten Fällen auf konventionelle Röntgenbilder in zwei
Ebenen. Allgemein akzeptierte Empfehlungen bezüglich einer
postoperativen 3D-Bildgebung existieren bisher nicht. Die Datenlage ist
spärlich. Sollte eine CT indiziert sein, so wird diese
üblicherweise ebenfalls mittel MDCT durchgeführt. Die
DVT-Diagnostik im Bereich des Handgelenkes ist noch wenig verbreitet. Diese
Arbeit beschäftigt sich mit dem möglichen Einsatz der DVT in der
perioperativen Diagnostik distaler Radiusfrakturen. Die DVT ermöglicht
eine exzellente Bildqualität bei potentiell niedrigerer
Strahlenbelastung im Vergleich zur MDCT, mit und ohne einliegendem
Osteosynthesematerial. Sie ist schnell verfügbar und
eigenständig durchführbar, was zeitsparend und effizient ist und
damit den klinischen Alltag erleichtert. Durch ihre vielen Vorteile stellt die
DVT bei der perioperativen Diagnostik von Radiusfrakturen eine empfehlenswerte
Alternative zum MDCT dar.
Kann Case Management den Umzug von Menschen mit Demenz in eine
Pflegeeinrichtung verzögern? – Ein systematisches Review
randomisiert kontrollierter Studien
Authors: Klaas-Ickler Dorothee , Kolominsky-Rabas Peter , Dietzel Nikolas 
Published: June 2023

Zusammenfassung
Hintergrund Demenz ist einer der Hauptgründe für
Pflegebedürftigkeit im Alter. Aufgrund der demografischen Entwicklung
wird das formelle und informelle Pflegepotential in Deutschland in den
nächsten Jahren weiter abnehmen. Der Förderung
häuslicher Versorgungsarrangements kommt darum ein hoher Stellenwert zu.
Case Management (CM) hat zum Ziel, eine effiziente Koordination von
Versorgungsleistungen, abgestimmt auf die Bedarfe und Ressourcen von chronisch
erkrankten Menschen und ihren Angehörigen, zu erreichen. Das Ziel dieser
Arbeit ist, die Auswirkung von CM auf den Verbleib von Menschen mit Demenz im
häuslichen Umfeld im Rahmen einer systematischen
Übersichtsarbeit zu untersuchen.
Methode Mit einer systematischen Literaturrecherche wurden fachrelevante
elektronische Datenbanken (Pubmed, CINAHL, PsycINFO, Scopus, CENTRAL, Gerolit,
ALOIS) auf randomisiert kontrollierte Studien (RCTs) durchsucht. Berichts- und
Studienqualität eingeschlossener Studien wurden mittels
CONSORT-Checkliste und Jadad-Skala bewertet.
Ergebnisse Eingeschlossen wurden 6 RCTs aus 5 verschiedenen
Gesundheitssystemen (Deutschland, USA, Niederlande, Frankreich, China). Bei 3
der RCTs zeigen sich signifikante Verzögerungen der Heimunterbringungen
bzw. signifikant geringere Heimeinzugsraten zugunsten der Interventionsgruppen,
3 weitere berichten von geringen, nicht statistisch signifikanten
Ergebnissen.
Schlussfolgerung Die Ergebnisse zeigen, dass CM-Ansätze das Potential
haben, den Verbleib von Menschen mit Demenz im eigenen Zuhause zu
verlängern. Die weitere Etablierung und Evaluation von
CM-Ansätzen sollte daher seitens der Entscheidungsträger im
Gesundheitswesen unbedingt gefördert werden. Bei der Planung und
Evaluation von CM-Ansätzen in spezifischen regionalen
Versorgungssettings sollten von Beginn an Barrieren und Chancen für eine
nachhaltige Implementierung in die Versorgungsketten berücksichtigt
werden.
Phytopharmaceuticals and Herbal Approaches to Target
Neurodegenerative Disorders
Authors: Islam Anas , Mishra Anuradha , Ahsan Rabia , Fareha Syed 
Published: June 2023

AbstractNeurodegeneration is characterized as the continuous functional and structural
loss of neurons, resulting in various clinical and pathological manifestations
and loss of functional anatomy. Medicinal plants have been oppressed from
ancient years and are highly considered throughout the world as a rich source of
therapeutic means for the prevention, treatment of various ailments.
Plant-derived medicinal products are becoming popular in India and other
nations. Further herbal therapies shows good impact on chronic long term
illnesses including degenerative conditions of neurons and brain. The use of
herbal medicines continues to expand rapidly across the world. The active
phytochemical constituents of individual plants are sometimes insufficient to
achieve the desirable therapeutic effects. Combining the multiple herbs in a
particular ratio (polyherbalism) will give a better therapeutic effect and
reduce toxicity. Herbal-based nanosystems are also being studied as a way to
enhance the delivery and bioavailability of phytochemical compounds for the
treatment of neurodegenerative diseases. This review mainly focuses on the
importance of the herbal medicines, polyherbalism and herbal-based nanosystems
and its clinical significance for neurodegenerative diseases.
Synthetic Strategies for Accessing Dibenzophosphole Scaffolds
Authors: Sakai Norio , Hattori Hiroyuki , Ishida Kento 
Published: June 2023

AbstractDibenzophospholes, phosphorus-containing π-conjugated cyclic compounds, have attracted considerable attention because of their potential applications in various functional materials such as those required for organic electroluminescent devices. Moreover, their synthetic methods have been widely developed. This review summarizes the construction strategies of dibenzophosphole scaffolds, including those developed recently.1	Introduction2	Construction of a Phosphole Skeleton Using Aryl Compounds2.1	[4+1] Cyclization between Biaryl Derivatives and P1 Units2.2	Intramolecular P–C Bond Formation of Biarylphosphines2.3	Intramolecular C–C Bond Formation of Diarylphosphines2.4	[3+2] Cyclization between Arylphosphines and Arenes3	Fused-Benzene Ring Formation4	Successive Phosphole Skeleton and Fused-Benzene Ring Formation5	Conclusions
Intrapleural Anticancer Therapy for Malignant Pleural Diseases: Facts or Fiction?
Authors: Agrawal Abhinav , Chaddha Udit , Shojaee Samira , Maldonado Fabien 
Published: June 2023

AbstractMalignant pleural diseases involves both primary pleural malignancies (e.g., mesothelioma) as well as metastatic disease involving the pleura. The management of primary pleural malignancies remains a challenge, given their limited response to conventional treatments such as surgery, systemic chemotherapy, and immunotherapy. In this article, we aimed to review the management of primary pleural malignancy as well as malignant pleural effusion and assess the current state of intrapleural anticancer therapies. We review the role intrapleural chemotherapy, immunotherapy, and immunogene therapy, as well as oncolytic viral, therapy and intrapleural drug device combination. We further discuss that while the pleural space offers a unique opportunity for local therapy as an adjuvant option to systemic therapy and may help decrease some of the systemic side effects, further patient outcome-oriented research is needed to determine the exact role of these treatments within the armamentarium of currently available options.