bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of novel composite bipolar plates using surface‐modified conductive carbon filler materials for polymer electrolyte membrane fuel cells
Authors: Mathew Cijo , Mohamed Samsudeen Naina , Lenin Singaravelu D. 
Published: August 2023

AbstractThe requirement for a lightweight bipolar plate (BP) for Proton Exchange Membrane Fuel Cell (PEMFC) is increasing to make it feasible to power hydrogen fuel cell electric vehicles. Composite BP with carbon materials as conductive fillers and polymer as the binder are preferable over pure graphite and metallic BP. This study investigates the effect of Surface‐enhanced flake graphite (SEFG) as a novel filler material in composite BP. A composite BP is developed with Epoxy Resin (ER) as the binder and Natural Flake Graphite (NFG), Carbon Black (CB) and SEFG as conductive fillers. Composite BP fabricated with 10 vol% SEFG, 10 vol% CB, and 40 vol% NFG exhibited an electrical conductivity of 158 S cm−1, flexural strength of 38 MPa, water contact angle of 90.410 and corrosion current density of 0.261 μA cm−2. The composite BP also achieved a density of 1.55 g cm−3, water absorption of 0.6% and thermal conductivity of 3.6 W m−1 K−1 at 120°C. These results are highly favorable for BPs used in PEMFC. This paper provides an insight into using surface‐modified conductive carbon filler materials to develop composite BP for application in PEMFC.
Highly hydrophilic and antifouling poly(vinylidene fluoride) hybrid ultrafiltration membranes incorporated with silver‐loaded iron‐based metal–organic frameworks
Authors: Rameesha Laila , Rana Dipak , Nagendran Alagumalai 
Published: August 2023

AbstractSilver‐loaded iron‐based metal–organic frameworks (Ag@FeBTC) are synthesized and incorporated with poly (vinylidene fluoride) (PVDF) to make hybrid ultrafiltration (UF) membranes and are efficiently utilized to treat water containing macromolecular pollutants. The chemical functionality and semi‐amorphous nature of the Ag@FeBTC are validated by FT‐IR and XRD, respectively. The morphology and elemental composition of PVDF/Ag@FeBTC membranes are probed by SEM and EDX mapping. The creation of pores is visibly seen in cross‐sectional SEM images and the improvement in roughness is noticed in AFM images. Because of the improved hydrophilicity of Ag@FeBTC on the PVDF membrane matrix, the contact angle is reduced to 33.9°. The excellent dispersion of Ag@FeBTC on the PVDF membrane matrix is observed through elemental mapping. The PVDF/Ag@FeBTC hybrid membranes exhibited higher pure water flux (160 L m−2 h−1) and greater than 90% rejection as well as flux recovery ratio for foulant removal (BSA and HA). The antimicrobial property of PVDF/Ag@FeBTC hybrid membranes is probed using a zone of inhibition test against E. coli and S. aureus, and the results revealed that the hybrid membranes possess superior antibacterial behavior. The long‐term stability of MOF in hybrid membranes is confirmed by AAS. Overall characterization and performance results of the hybrid PVDF/Ag@FeBTC UF membrane clearly demonstrated its potential use for water treatment applications.
Sorbitol‐based epoxy anti‐smudge coatings with liquid repellency for various applications
Authors: Wu Zhijun , Lin Yixing , Yuan Xinyi , Zhou Xiaosong , Luo Jin , Zhou Xunfu , Liu Canqun , Qu Jinqing 
Published: August 2023

AbstractIn this work, a novel sorbitol‐based epoxy anti‐smudge coatings (EPs) system were developed with sorbitol epoxy resin (SE) as raw material, branched amino poly (dimethysiloxane) (PDMS‐NH2) as a liquid‐repellent agent and isophorone diamine as a curing agent. These coatings have excellent thermal stability. The resultant coatings with 0.5 wt% PDMS‐NH2 content incorporated are exhibited remarkable self‐cleaning performance, and has good liquid repellency to various liquids (water, fingerprint fluid, strong acid solution, cola, ink, hexadecane, pump oil, milk, corn oil, soy sauce, machine oil, and strong alkali solution), sliding down the coating surface and leaving no trace. Besides, these sorbitol‐based epoxy anti‐smudge coating system show highly transparency, excellent corrosion resistance, and excellent anti‐ink performance on different substrates. More strikingly, sorbitol‐based epoxy anti‐smudge coatings can be dyed into different colors without affecting its anti‐ink performance, indicating sorbitol‐based epoxy anti‐smudge coatings possessed practical application availability.
Preparation and properties of SBR/PPTA nanocomposite via in‐situ interfacial polycondensation
Authors: Zhao Zhiping , Gong Xiangjun , Sun Changmei , Zhang Ying , Qu Rongjun , Wang Ying 
Published: August 2023

AbstractIn this article, Styrene butadiene rubber/poly‐p‐phenylene terephthamide (SBR/PPTA) nanocomposite was synthesized via in‐situ interfacial polycondensation of para‐phenylenediamine (PPD) and para‐benzoyl chloride (TPC) between the interface of SBR‐containing cyclohexanone (CYC) solution and water. Fourier transform‐infrared spectroscopy (FTIR) and x‐ray diffraction (XRD) confirmed the formation of PPTA in SBR matrix. Transmission electron microscopy (TEM) indicated PPTA nanosheets were uniformly dispersed in the SBR matrix. The thermal stability and mechanical properties of SBR/PPTA nanocomposite were also studied. Results showed that PPTA significantly improved the mechanical properties and thermal stability of SBR. The tensile strength and 200% tensile stress of SBR/PPTA‐3 were 120.9% and 150.8% higher than those of Pure rubber, respectively. The tensile strength and elongation at break of SBR/ PPTA‐3‐30% were 187.2% and 36.9% higher than those of Pure rubber, enabling promising applications of this new composite rubber material.
Frequency and polymorphism of acetylcholinesterase gene involved in the organophosphate resistance ofMusca domesticain Guizhou Province, China
Authors: Yang Xi , Mou Rong , Liang Qiuguo , Cheng Jinzhi , Wu Yuanming , Tan Weilong , Wu Jiahong 
Published: August 2023

AbstractOrganophosphate (OP) resistance has been prevalent inMusca domesticapopulations worldwide since 1960s. Previous studies have demonstrated that point mutations of the acetylcholinesterase gene (Ace) are one of the important molecular mechanisms underlying OP resistance. However, few studies have investigated the molecular mechanisms of OP resistance in the past 10 years in China. In this study, we investigated the status of OP resistance and genetic diversity ofAcein the field populations of houseflies in Guizhou Province of China. The bioassays showed that the houseflies had 142–304‐fold resistance to dichlorvos (DDVP) and 122–364‐fold resistance to temephos, compared to the susceptible houseflies. Five nonsynonymous mutations (Y226F, V260L, G342A/V, F407Y) inAcewere detected among the 7 field populations, with an average frequency of 5.4%, 55%, 68%, 32%, and 94%, respectively, of which the Y226F mutation had not been reported previously. Eleven combinations of triple mutations (at positions 260, 342, and 407) were observed, of which the combination 260L/V+342A/V+407Y was predominant. The ZY and AS populations showed greatest diversity of allelic combination and the other five populations showed different distributions among different regions. These results indicate that the resistance to OPs is prevalent among the housefly populations and target‐site insensitivity is the main cause of resistance in Guizhou Province. The difference in distribution and the allelic diversity ofAcein field populations may be due to the complexity and variability of insecticide application. It is necessary to monitor resistance to insecticides and conduct management of houseflies in Guizhou Province.
Molecular characterization and expression patterns of a ryanodine receptor in soybean looper, Chrysodeixis includens
Authors: Isbilir Sena , Catchot Beverly , Catchot Lauren , Musser Fred R. , Ahn Seung‐Joon 
Published: August 2023

AbstractDiamide insecticides, such as chlorantraniliprole, have been widely used to control insect pests by targeting the insect ryanodine receptor (RyR). Due to the efficacious insecticidal activity of diamides, as well as an increasing number of resistance cases, the molecular structure of RyR has been studied in many economically important insects. However, no research has been conducted on diamide resistance and RyR in the soybean looper, Chrysodeixis includens, a significant crop pest. In this study, we found moderate resistance to chlorantraniliprole in a field population from Puerto Rico and sequenced the full‐length cDNA of the C. includens RyR gene, which encodes a 5124 amino acid‐long protein. Genomic analysis revealed that the CincRyR gene consists of 113 exons, one of the largest exon numbers reported for RyR. Alternative splicing sites were detected in the cytosolic region. The protein sequence showed high similarity to other noctuid RyRs. Conserved structural features included the selectivity filter motif critical for ryanodine binding and ion conduction, as well as various domains involved in ion transport. Two mutation sites associated with diamide resistance in other insects were screened but not found in the Puerto Rico field populations or in the susceptible lab strain. Gene expression analysis indicated high expression of RyR in the third instar larval stage, particularly in muscle‐containing tissues. Furthermore, exposure to a sublethal dose of chlorantraniliprole reduced RyR expression levels after 96 h. This study provides a molecular basis for understanding RyR structure and sheds light on potential mechanisms of diamide resistance in C. includens.
Design, synthesis, and evaluation of new benzimidazole‏ ‏‎thiourea ‎derivatives as antitumor agents
Authors: Aboutaleb Mohamed H. , El‐Gohary Nadia S. , Ghabbour Hazem A. , El‐Kerdawy Mohamed M. 
Published: August 2023

AbstractNovel benzimidazole thiourea derivatives were designed and synthesized based on sorafenib as a lead compound. The benzimidazole moiety was traded by the pyridine ring to enhance the hydrophobic interaction and retain hydrogen bonding in the hinge region, while lipophilic moieties with different bulkiness were employed in the deep hydrophobic pocket for better hydrophobic interactions. Thiourea as a urea bioisostere was also utilized. Substantial activity was demonstrated against a leukemia subpanel in an in vitro antitumor screening at the NCI. In the single‐dose assay, compounds 7i, 7j, and 7l had a GI%) higher than sorafenib against most leukemia cell lines (GI% = 86.2%–137.1%), while in the five‐dose assay, compound 7l outperformed sorafenib against the HL‐60(TB) and SR leukemia cell lines in terms of GI50, TGI, and LC50. Compound 7l also caused cycle arrest at the G0–G1 and S phases in the HL‐60(TB) leukemia cell line and induced apoptosis via elevating the Bax/Bcl‐2 ratio and increasing caspases 3, 7, and 9 by 5.1‐, 3.2‐, and 5.2‐fold, respectively. Compounds 7i, 7j, and 7l also inhibited the vascular ‎endothelial growth factor receptor‐2 (VEGFR‐2), B‐Raf(V600E), and platelet‐derived growth factor receptor ‎beta (PDGFR‐β) enzymes with an IC50 range of 0.063–0.44 μM. COMPARE analysis and a molecular docking study were also performed to predict the possible mechanism of action and binding mode, respectively.
Well‐being spectrum traits are associated with polygenic scores for autism
Authors: Mohammad Salahuddin , de Ruijter Markus J. T. , Rukh Gull , Rask‐Andersen Mathias , Mwinyi Jessica , Schiöth Helgi B. 
Published: August 2023

AbstractIndividuals with autism spectrum disorder (ASD) tend to experience lower well‐being as demonstrated mostly for children and adolescents in epidemiological studies. A further investigation of inclusive well‐being, in terms of five well‐being spectrum (5‐WBS) traits including neuroticism, depression, loneliness, life satisfaction, and positive affect, among adults with ASD may deepen our understanding of their well‐being, and lead to the possibility to further modify societal supportive mechanisms for individuals with ASD. This study aims to investigate if a genetic predisposition for ASD is associated with 5‐WBS traits using polygenic risk score (PRS) analysis. PRS for ASD were calculated based on the latest genome‐wide association study of ASD by the Psychiatric Genetics Consortium (18,381 cases, 27,969 controls) and were created in the independent cohort UK Biobank. Regression analyses were performed to investigate the association between ASD PRS and 5‐WBS traits in the UK Biobank population including 337,423 individuals. ASD PRS were significantly associated with all 5‐WBS traits, showing a positive association with the negative WBS traits, neuroticism (max R2 = 0.04%, p < 1 × 10−4), depression (max R2 = 0.06%, p < 1 × 10−4), loneliness (max R2 = 0.04%, p < 1 × 10−4), and a negative association with the positive WBS traits, life satisfaction (max R2 = 0.08%, p < 1 × 10−4), positive affect (max R2 = 0.10%, p < 1 × 10−4). The findings suggest that adults carrying a high load of risk single nucleotide peptides (SNPs) for ASD are more likely to report decreased well‐being. The study demonstrates a considerable connection between susceptibility to ASD, its underlying genetic etiology and well‐being.
Why it is so challenging to perform economic evaluations of interventions in autism and what to do about it
Authors: Tsiplova Kate , Ungar Wendy J. 
Published: August 2023

AbstractEconomic evaluation is used to determine the optimal provision of services and programs under budget constraints and to inform public and private payer funding decisions. To maximize value‐for‐money in the design and delivery of programs and services for persons with autism spectrum disorder (ASD), it's essential to generate high‐quality economic evidence to inform budget allocation. There is a paucity however, of economic evaluations of interventions for ASD. This is due in part to challenges in conducting economic evaluations in this population and the lack of guidance on suitable approaches. These challenges are related to the inherent heterogeneity of the autistic population; establishing short‐ and long‐term effectiveness; measurement of costs and the availability of valid instruments for collecting economic data; the appropriateness of outcomes for use in economic evaluation; and achieving statistical power. This commentary addresses a lack of awareness and needed guidance on these issues by discussing the challenges and providing recommendations for how economic evaluations in ASD could be improved to generate high‐quality evidence for program funding decision‐making.
Enhanced Electrochemical Properties of γ‐MnS@rGO Composite as Anodes for Lithium‐Ion Batteries
Authors: Nam Wonbin , Seong Honggyu , Moon Joon Ha , Jin Youngho , Kim Geongil , Yoo Hyerin , Jung Taejung , Yang MinHo , Cho Se Youn , Choi Jaewon 
Published: August 2023

AbstractManganese sulfide (MnS) is a metal chalcogenide with a high theoretical capacity (616 mAh g−1) and can be used as an alternative anode material for lithium‐ion batteries. Generally, metal chalcogenides have intrinsic limitations, such as low stability resulting from volume expansion and poor electronic conductivity. Herein, the authors propose a synthesis strategy of nano‐sized γ‐MnS, and one‐step composite process by the growth of nanoparticles on the surface of reduced graphene oxide (rGO). These strategies can effectively prevent particle aggregation and enhance an electrochemical stability. The electrochemical performance of the γ‐MnS@rGO composite was evaluated using cyclic voltammetry (CV) and galvanostatic charge and discharge measurements. The results showed that the γ‐MnS@rGO composite delivered a high specific capacity (624 mAh g−1 at 0.5 A g−1 after 100 cycles), good cycling stability, and excellent rate capability compared to bare γ‐MnS.
The evolution of selective autophagy as a mechanism of oxidative stress response
Authors: Ratliffe Joshua , Kataura Tetsushi , Otten Elsje G. , Korolchuk Viktor I. 
Published: August 2023

AbstractAgeing is associated with a decline in autophagy and elevated reactive oxygen species (ROS), which can breach the capacity of antioxidant systems. Resulting oxidative stress can cause further cellular damage, including DNA breaks and protein misfolding. This poses a challenge for longevous organisms, including humans. In this review, we hypothesise that in the course of human evolution selective autophagy receptors (SARs) acquired the ability to sense and respond to localised oxidative stress. We posit that in the vicinity of protein aggregates and dysfunctional mitochondria oxidation of key cysteine residues in SARs induces their oligomerisation which initiates autophagy. The degradation of damaged cellular components thus could reduce ROS production and restore redox homeostasis. This evolutionarily acquired function of SARs may represent one of the biological adaptations that contributed to longer lifespan. Inversely, loss of this mechanism can lead to age‐related diseases associated with impaired autophagy and oxidative stress.
Cashew nut shell oil as a potential feedstock for biodiesel production: An overview
Authors: Kandaswamy Srinivasan , Swarupa Venkatesa Murthy , Sur Souvik , Choubey Gautam , Devarajan Yuvarajan , Mishra Ruby 
Published: August 2023

AbstractBiodiesel outperforms diesel in emissions and engine performance. They burn efficiently in diesel engines and are eco‐friendly. Since cashew nut shell liquid (CNSO) is waste, commercial biodiesel production from it should be profitable. CNSO is cheap and can reduce cashew processing factory waste. From cashew kernels, CNSL is extracted using various mechanical, thermal, and solvent extraction techniques. This article examines current research into using cashew nutshell liquid biodiesel (CNSLBD) in diesel engines. The work also discusses Indian biodiesel demand, availability, export information, life cycle cost analysis, cost economics of per hectare yield, Indian government initiative of CNSO. This review also evaluates the viability of this fuel as an alternative energy source. CNSLBD is a prospective alternative fuel that has the potential to benefit both the cashew nut industry and the energy industry. In addition to this, the study examines the procedures for extracting CNSO. According to the findings of the study, CNSO is a prospective alternative fuel that has the potential to benefit both the cashew nut industry and the energy industry.
Development and validation of an HPLC method for quantification of dolutegravir in human plasma
Authors: Li Dongsheng , Fu Qiang , Du Xiaoli , Li Taisheng 
Published: August 2023

AbstractDolutegravir (DTG) has been the first‐line drug in many human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) guidelines for the treatment of naïve and experienced HIV‐infected individuals, which calls for cost‐effective and convenient methods for quantitative detection of DTG in human plasma for pharmacokinetic studies and patient adherence evaluation. Here, an HPLC–ultraviolet method in combination with liquid–liquid extraction with isocratic elution was developed for the first time. The analysis was performed on a CLC‐ODS column (6 mm internal diameter × 15 cm, 5 μm) using a mixture of acetonitrile and phosphate buffer (40:60, v/v) as the mobile phase at the flow rate of 1 mL/min. Using triamcinolone as the internal standard, 100 μL of plasma sample was extracted by methyl tert‐butyl ether, followed by evaporating under nitrogen stream, re‐dissolving with 100 μL mobile phase, and injection of 20–40 μL of supernatant into the chromatographic system. The linearity of DTG was good in the range of 0.05–10 μg/mL (r = 0.9995), and the inter‐ and intra‐day variabilities were 0.4%–4.3% (n = 10) and 1.2%–6.2% (n = 10) for the lower limit of quantification, low‐, medium‐, and high‐concentration quality control samples (0.05, 0.1, 0.8, and 8 μg/mL), respectively, while the methodological and extraction recoveries were 98.0%–103.0% (n = 20) and 65.2%–75.7% (n = 3), respectively. This method was successfully applied to analyze DTG plasma concentration in 84 Chinese patients with HIV.
Yujin powder improves large intestine dampness‐heat syndrome by regulating gut microbiota and serum metabolism
Authors: Zhang Yahui , Yao Wanling , Zhang Wangdong , Wen Yanqiao , Hua Yongli , Ji Peng , Wei Yanming 
Published: August 2023

AbstractLarge intestine dampness‐heat syndrome (LIDHS) is a common syndrome type in animal diarrheal diseases. Yujin powder (YJP) is one of the classic prescriptions for treating damp‐heat diarrhea. The aim of this study was to investigate the regulatory effects of YJP on gut microbiota and serum metabolism in LIDHS rats using 16S rRNA sequencing and nontargeted metabolomics. The LIDHS rat model was induced through a high‐sugar and high‐fat diet, exposure to a high‐temperature and high‐humidity environment, and infection with Escherichia coli. The results demonstrated that the administration of YJP resulted in a decrease in the abundance of Desulfovibrio, Parabacteroides, Bacteroides, Allobaculum, Escherichia, Butyricimonas, Parasutterella, and Blautia and an increase in Ruminococcus, Akkermansia, Roseburia, and Lachnoclostridium. A total of 25 potential biomarkers were identified in three groups of rats. These metabolites were primarily involved in glycerophospholipid metabolism, taurine and hypotaurine metabolism, glycerol ester metabolism, arachidonic acid metabolism, primary bile acid synthesis, and tryptophan metabolism. Our study demonstrated that YJP has the potential to alleviate LIDHS by modulating gut microbial and serum metabolic homeostasis. These results establish a foundation and offer valuable guidance for the utilization of YJP in the treatment of LIDHS.
Drivers and barriers in the institutionalisation of circular economy practices in food supply chains: A review
Authors: Ouro‐Salim Omar , Guarnieri Patricia 
Published: August 2023

AbstractThe circular economy (CE) has gained global attention for its potential to promote sustainable production and consumption through continuous growth and the efficient use of resources. Despite several reports highlighting its benefits, there is still a lack of concrete and proven studies examining the importance of institutional pressures for the transition towards CE in food supply chains. This study aims to address this gap by conducting a Systematic Literature Review (SLR) to identify the drivers and barriers to the institutionalisation of CE in food supply chains, and to propose practical and managerial implications for achieving this transition through institutional pressure. We reviewed 25 studies and conducted a descriptive analysis of papers per year and journal, followed by a categorical thematic analysis. The results indicate that normative pressures were the most frequently identified among the different institutional pressures, followed by mimetic and coercive pressures. Therefore, promoting CE in food supply chains may require the implementation of laws, policies, and strict governance to reduce risks. This paper contributes to the existing literature and provides valuable insights for researchers and practitioners interested in the transition towards a CE in food supply chains.