bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficiently Inhibiting Systemic Inflammatory Cascades by Fullerenes for Retarding HFD‐Fueled Atherosclerosis
Authors: Su Sheng'e , Zhen Mingming , Zhou Chen , Cao Xinran , Sun Zihao , Xu Yuan , Li Lei , Jia Wang , Wu Zhanfeng , Wang Chunru 
Published: January 2023

AbstractAtherosclerosis accounts for major mortality of cardiac‐cerebral vascular diseases worldwide. Pathologically, persistent inflammation dominates the progression of atherosclerosis, which can be accelerated by a high‐fat diet (HFD), possibly through triggering local intestinal oxidative stress and ensuing gut barrier dysfunction. Current pharmacotherapy has been disappointing, ascribed to limited therapeutic efficacy and undesirable side effects. Hence it is compelling to explore novel efficient anti‐atherosclerotic drugs with minimal toxicity. Herein, two fullerene‐based therapies with exceptional antioxidant capacity, in the form of water‐soluble injectable fullerene nanoparticles (IFNPs) and oral fullerene tablets (OFTs), are demonstrated to retard HFD‐fueled atherosclerosis in ApoE−/‐ mice with favorable biosafety. Especially, OFTs afford robust anti‐atherosclerotic therapeutic even against advanced plaques, besides stabilizing plaques with less lipid deposition and improved collagen expression. Specifically, it is identified that OFTs can ameliorate HFD‐induced dysregulated intestinal redox homeostasis and restore gut barrier integrity, thereby restraining the translocation of luminal lipopolysaccharide (LPS) into the bloodstream. Furthermore, significantly reduced circulating LPS after OFTs treatment contributes to down‐regulated LPS/TLR4/NF‐κB signaling in aortic focal, which further mitigates local inflammation and disease development. Overall, this study confirms the universal anti‐atherosclerotic effect of fullerenes and provides a novel therapeutic mechanism via modulating intestinal barrier to attenuate atherosclerosis.
Lithium‐Containing Biomaterials Stimulate Cartilage Repair through Bone Marrow Stromal Cells‐Derived Exosomal miR‐455‐3p and Histone H3 Acetylation
Authors: Liu Lu , Yu Fei , Chen Lei , Xia Lunguo , Wu Chengtie , Fang Bing 
Published: January 2023

AbstractThe repair of damaged cartilage still remains a great challenge in clinic. It is demonstrated that bone marrow stromal cells (BMSCs)‐chondrocytes communication is of great significance for cartilage repair. Moreover, BMSCs have been confirmed to enhance biological function of chondrocytes via exosome‐mediated paracrine pathway. Lithium‐containing scaffolds have been reported to effectively promote cartilage regeneration; however, whether lithium‐containing biomaterial could facilitate cartilage regeneration through regulating BMSCs‐derived exosomes has not been illustrated. In the study, the model lithium‐substituted bioglass ceramic (Li‐BGC) is selected and regulatory effects of BMSCs‐derived exosomes after Li‐BGC treatment (Li‐BGC‐Exo) are systemically evaluated. The data reveal that Li‐BGC‐Exo notably promotes chondrogenesis, which attributes to the upregulated exosomal miR‐455‐3p transfer, consequently leads to suppression of histone deacetylase 2 (HDAC2) and enhanced histone H3 acetylation in chondrocytes. Notably, BMSCs‐derived exosomes after LiCl treatment (LiCl‐Exo) exhibits the similar regulatory effect with Li‐BGC‐Exo, indicating that the pro‐chondrogenesis capability of them is mainly owing to the lithium ions. Furthermore, the in vivo study proves that LiCl‐Exo remarkably facilitates cartilage regeneration. The research may provide novel possibility for the intrinsic mechanism of chondrogenesis trigged by lithium‐containing biomaterials, and suggests that application of lithium‐containing scaffolds may be a promising strategy for cartilage regeneration.
Novel Titanium Implant: A 3D Multifunction Architecture with Charge‐Trapping and Piezoelectric Self‐Stimulation
Authors: Sun Lei , Chen Xuzhuo , Ma Kun , Chen Ruiguo , Mao Yi , Chao Rui , Wang Hui , Yu Bin , Wang Junfeng , Zhang Shanyong 
Published: January 2023

AbstractImplant‐associated infection and inflammation are the main causes of implant failure, causing irreversible damage and significantly increasing clinical risks and economic losses. In this study, a 3D multifunctional architecture is constructed that consisted of hierarchical TiO2 nanotubes (NTs) and electrospun polyvinylidene fluoride nanofiber layers on the surface of a titanium implant. The movement of bacteria through the nanofiber layer is facilitated by its appropriate pore sizes and electrostatic interactions to reach the NT layer where the bacteria are killed by positive charge traps. In contrast, the macrophages tend to adhere to the nanofiber layer. The mechanical interactions between the macrophages and piezoelectric nanofibers generate a self‐stimulated electric field that regulated an anti‐inflammatory phenotype. This study provides a new method for multifunctional implant materials with antibacterial, piezoelectrically self‐stimulated anti‐inflammatory, and osteointegration properties that are driven by electrical stimulation.
Labeling Assembly of Hydrophilic Methionine into Nanoparticle for Mild‐Heat Mediated Immunometabolic Therapy
Authors: Zheng Xiao , Liu Ying , Zhang Tingting , Zhao Yuge , Liu Yiqiong , Zang Jie , Chong Gaowei , Li Yan , Yang Yushan , Yang Yan , Gu Jingjing , He Ruiqing , Liu Bingbing , Yin Weimin , Dong Haiqing , Li Yongyong 
Published: January 2023

AbstractMethionine metabolism has a significant impact on T cells’ survival and activation even in comparison to arginine, a well‐documented amino acid in metabolic therapy. However, hydrophilic methionine is hardly delivered into TME due to difficult loading and rapid diffusion. Herein, the labeling assembly of methionine into nanoparticle is developed to overcome high hydrophilicity for mild‐heat mediated immunometabolic therapy. The strategy is to first label methionine with protocatechualdehyde (as the tag) via reversible Schiff‐base bond, and then drive nanoassembly of methionine (MPC@Fe) mediated by iron ions. In this fashion, a loading efficiency of 40% and assembly induced photothermal characteristics can be achieved. MPC@Fe can accumulate persistently in tumor up to 36 h due to tumor‐selective aggregation in acidic TME. A mild heat of 43 °C on tumor by light irradiation stimulated the immunogenic cell death and effectively generated CD8+ T cells. Notably, MPC@Fe assisted by mild heat promoted 4.2‐fold of tumor‐infiltrating INF‐γ+CD8+ T cells, leading to an inhibition ratio of 27.3‐fold versus the free methionine. Such labeling assembly provides a promising methionine delivery platform to realize mild heat mediated immunometabolic therapy, and is potentially extensible to other amino acids.
Ecology and age, but not genetic ancestry, predict fetal loss in a wild baboon hybrid zone
Authors: Fogel Arielle S. , Oduor Peter O. , Nyongesa Albert W. , Kimwele Charles N. , Alberts Susan C. , Archie Elizabeth A. , Tung Jenny 
Published: January 2023

AbstractObjectivesPregnancy failure represents a major fitness cost for any mammal, particularly those with slow life histories such as primates. Here, we quantified the risk of fetal loss in wild hybrid baboons, including genetic, ecological, and demographic sources of variance. We were particularly interested in testing the hypothesis that hybridization increases fetal loss rates. Such an effect would help explain how baboons may maintain genetic and phenotypic integrity despite interspecific gene flow.Materials and MethodsWe analyzed outcomes for 1020 pregnancies observed over 46 years in a natural yellow baboon‐anubis baboon hybrid zone. Fetal losses and live births were scored based on records of female reproductive state and the appearance of live neonates. We modeled the probability of fetal loss as a function of a female's genetic ancestry (the proportion of her genome estimated to be descended from anubis [vs. yellow] ancestors), age, number of previous fetal losses, dominance rank, group size, climate, and habitat quality using binomial mixed effects models.ResultsFemale genetic ancestry did not predict fetal loss. Instead, the risk of fetal loss is elevated for very young and very old females. Fetal loss is most robustly predicted by ecological factors, including poor habitat quality prior to a home range shift and extreme heat during pregnancy.DiscussionOur results suggest that gene flow between yellow and anubis baboons is not impeded by an increased risk of fetal loss for hybrid females. Instead, ecological conditions and female age are key determinants of this component of female reproductive success.
Gas/particle flow and pressure variation characteristics of Ende pulverized coal gasifier equipped with ejector
Authors: Song Minhang , Tang Di , Liu Xiaoying , Xu Yang 
Published: January 2023

AbstractEnde pulverized coal gasifier (EPCG), as a typical representative of circulating fluidized bed gasifier, has been widely used in gasification field. The return conduit of EPCG is generally not equipped with a feedback control device (FCD), which tends to result in a low solid circulation rate (Gs) and high unburned combustibles in fly ash. To address these issues, a new technique using the ejector as the FCD was designed to provide a stable pressure barrier and improve solid circulation. Preliminary thermal experiments demonstrated the feasibility of improving the EPCG with injector system. Currently, the specific mechanisms that contribute to further optimize this technology have not been systematically studied. Considering the large impact of ejector operation on solid circulation rate and stability as well as syngas production, this work adopts a gas/particle 1:15 cold EPCG bench to investigate the gas/particle flow and pressure variation characteristics before and after ejector operation and under different working medium pressures (Pp). When the ejector operates at the design pressure Ps = 0.187 MPa, the outlet pressure of the return conduit is slightly larger than the furnace bottom pressure, thus preventing the reverse gas flow at the furnace bottom. The particle velocity and concentration distribution in the furnace are basically consistent with that without the ejector, showing a similar central spout region and near‐wall annulus flow region. As Pp increases from 0.04 to 0.24 MPa, the average particle velocity in the return conduit increases from 0.95 to 2.4 m/s, the particle concentration decreases from 0.088 to 0.051, and the solid circulation rate increases from 0.37 to 0.53 kg/h. The ejector outlet pressure gradually increases, the inlet pressure decreases, and the pressure barrier provided by the ejector rises from 1052 to 3640 Pa. When Pp is 0.12 MPa, the ratio of GN2/Gair is 0.91%, which can achieve the purpose of continuous and stable pressurization with a small amount of nitrogen.
Understanding glycidylation reaction for the formation of pure mono, diglycidyl and dual monomers as glycidyl methacrylate of vanillyl alcohol
Authors: Caillol Sylvain , Auvergne Rémi , Manseri Abdelatif , Boutevin Gilles , Boutevin Bernard , Grimaldi Marina , Balaguer Patrick 
Published: January 2023

AbstractThe mono epoxy methacrylate and the diepoxy of vanillyl alcohol (DGEVA) are products already known and reported in literature. However, their respective synthesis processes lead to mixtures of products and side‐products. Hence, the final reaction yields are low, mainly due to the purification steps. The mixture of by‐products obtained is due to the presence of phenol and methylol in raw vanillin. In this article, we have proposed selective synthesis methods avoiding the formation of these by‐products, which allows to consider the industrialization of these synthetic routes. Thanks to the difference in reactivity and the basicity of the catalysts used, we were able either to propose a two‐step synthesis of the mono‐epoxy vanilin, or to epoxidize the two hydroxyl groups to obtain the diepoxy in a single step. Finally, a toxicology study of pure vanillyl alcohol and pure DGEVA was carried out to demonstrate the interest of vanillyl alcohol as a potential substituent of bisphenol A.
Synthesis of five‐ring‐fused azepinone derivatives from bis‐isatins via sequential 6π‐electrocyclic ring closure, ring expansion, and dehydrogenation process
Authors: Lee Sangku , Lee Junseong , Kim Jae Nyoung 
Published: January 2023

AbstractFive‐ring‐fused azepinone derivatives were synthesized serendipitously from bis‐isatins via sequential 6π‐electrocyclic ring closure, ring expansion, and dehydrogenation process in moderate yields (34%–47%). The reaction was carried out in diphenyl ether at 230 °C for 4–12 h under O2balloon atmosphere.
Synthesis, crystal structure, and photophysical properties of mononuclear and dinuclear palladium BODIPY chromophores
Authors: Gupta Gajendra , Lee Junseong , Lee Chang Yeon 
Published: January 2023

AbstractMononuclear and dinuclear palladium‐centered boron dipyrromethene (BODIPY) complexes, HBDPPdI and BDPPd2I2, respectively, were synthesized by the direct insertion of a palladium source into iodine‐substituted BODIPY chromophores. The molecular structures of both metal complexes were characterized using several analytical techniques, including single crystal x‐ray diffraction, to find that Pd(0) is coordinated directly to the ligand through a PdC bond facilitated by the insertion reaction. The photophysical properties of these complexes were also detailed.
Fatigue after COVID‐19 in non‐hospitalized patients according to sex
Authors: Mazurkiewicz Iwona , Chatys‐Bogacka Zaneta , Slowik Joanna , Klich‐Raczka Alicja , Fedyk‐Lukasik Malgorzata , Slowik Agnieszka , Wnuk Marcin , Drabik Leszek 
Published: January 2023

AbstractBackgroundLimited evidence exists on sex differences in post‐COVID fatigue among non‐hospitalized patients. Therefore, aim of the study was to evaluate the course of chronic fatigue symptoms in non‐hospitalized subjects with the SARS‐CoV‐2 infection, according to sex.MethodsPatients and staff from the University Hospital in Krakow anonymously and retrospectively completed neuropsychological questionnaire that included eight symptoms of chronic fatigue syndrome. The presence of these symptoms was assessed before COVID‐19 and 0–4, 4–12, and >12 weeks postinfection. The inclusion criteria were as follows: age 18 or more years, >12 weeks since the onset of the SARS‐CoV‐2 infection, and diagnosis confirmed by the RT‐PCR from anasopharyngeal swab.ResultsWe included 303 patients (79.53% women, 47.52% medical personnel) assessed retrospectively after a median of 30 (interquartile range: 23–35) weeks since the onset of symptoms. A higher prevalence of at least one chronic fatigue symptom was found in females in all time intervals after the onset of COVID‐19 compared to males (p < .036). Women, compared to men, more often experienced persistent fatigue, not caused by effort and persisting after rest (for <4 weeks, odds ratio [OR] = 2.31, 95% confidence interval [CI]: 1.13–4.73; for 4–12 weeks, OR = 1.95, 95% CI: 1.06–3.61), non‐restorative sleep (for <4 weeks, OR = 2.17, 95% CI: 1.23–3.81; for >12 weeks, OR = 1.95, 95% CI: 1.03–3.71), and sore throat (for <4 weeks, OR = 1.97, 95% CI: 1.03–3.78; for 4–12 weeks, OR = 2.76, 95% CI: 1.05–7.27). Sex differences in headache, arthralgia, and prolonged postexercise fatigue were observed only during the first 4 weeks (OR = 2.59, 95% CI: 1.45–4.60, OR = 2.97, 95% CI: 1.02–8.64, and OR = 1.87, 95% CI: 1.01–3.51, respectively). There were no differences between women and men in myalgia and self‐reported lymph node enlargement.ConclusionsThe course of post‐COVID fatigue differs significantly between sexes in non‐hospitalized individuals with COVID‐19, with women more often suffering from persistent fatigue, not caused by effort and persisting after rest, non‐restorative sleep, and sore throat.
Comparison of characteristics and outcomes of young‐onset versus average onset pancreatico‐biliary adenocarcinoma
Authors: Jayakrishnan Thejus , Nair Kanika G. , Kamath Suneel D. , Wei Wei , Estfan Bassam N. , Krishnamurthi Smitha S. , Khorana Alok A. 
Published: January 2023

AbstractBackgroundYoung‐onset gastrointestinal malignancies appear to be increasing in incidence. There are limited data on young‐onset pancreaticobiliary adenocarcinoma (YO‐PBA).MethodsThe study comprised patients with PBA (pancreatic adenocarcinoma, intra‐, and extra‐hepatic cholangiocarcinoma) and included in the National Cancer Database (NCDB) between 2004 and 2017. YO‐PBA was defined as a diagnosis at age less than 50 years. Logistic regression to assess factors associated with YO‐PBA status, and cox proportional hazards modeling to associate relevant factors with overall survival was performed.ResultsThe study cohort comprised 360,764 patients, with 20,822 (5.8%) YO‐PBA. YO‐PBA was associated with (p‐values<0.0001 for all): male sex (6.3% YO‐male out of all male patients vs. 5.2% YO‐female, OR 1.29, 95% CI 1.25–1.33), Black race (7.9% YO‐Black vs. 5.0% YO‐White, OR 1.72, 95% CI 1.64–1.80), lower income (6.4% YO‐lowest household income based group vs. 5.5% highest, OR 1.08, 95% CI 1.03–1.13). YO‐PBA were more likely to present with stage‐IV disease (6.4% YO‐Stage IV of all stage IV vs. 5.4% YO‐Stage I–III, OR 1.25, 95% CI 1.21–1.29 p‐value < 0.0001). Factors associated with overall survival (OS) in non‐operable patients included—sex ‐ male vs. female, HR 1.12 (95% CI 1.08–1.15); race ‐ Black vs. White, HR 1.23 (95% CI 1.06–1.42); income group ‐ lowest vs. highest, HR 1.33 (95% CI 1.27–1.39), and treatment center type ‐ academic vs. nonacademic center, HR 0.87 (95% CI 0.85–0.90).ConclusionsSocioeconomic factors significantly impact incidence and outcomes for young‐onset pancreaticobiliary adenocarcinoma (YO‐PBA). More work is needed to help understand the mechanisms involved while addressing the disparities.
Phase 1 dose escalation study of FGFR4 inhibitor in combination with pembrolizumab in advanced solid tumors patients
Authors: Xu Jianming , Cui Jiuwei , Jiang Haiping , Zeng Yan , Cong Xiuyu 
Published: January 2023

AbstractObjectiveInhibition of fibroblast growth factor (FGF) 19‐FGF Receptor 4 (FGFR4) signaling demonstrates potent anticancer activity. EVER4010001 is a highly selective FGFR4 inhibitor and pembrolizumab is approved for the treatment of several solid tumors. This study determined the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D), pharmacokinetics, safety, and preliminary efficacy of EVER4010001 plus pembrolizumab in patients with advanced solid tumors.MethodsThis Phase 1, multicenter, open‐label study enrolled 19 Asian–Chinese patients (57.9% male: median age 58 years) with advanced solid tumors. For “3+3” dose escalation, 3–6 patients received treatment at each dose level (EVER4010001 40, 60, 80, or 100 mg twice daily [BID] plus pembrolizumab 200 mg every 3 weeks).ResultsAt the data cutoff (August 12, 2021), no dose‐limiting toxicities (DLTs) were reported at 40 mg–80 mg. At 100 mg, 2 (40.0%) patients had 3 DLTs within the 28‐day DLT observation period after first administration. Median time to peak EVER4010001 concentration (Tmax) was 0.55–1.03 hours. Mean terminal EVER4010001 half‐life (T1/2) was 4.00–4.92 hours. The area under the concentration‐time curve (AUC0–t) and maximum observed concentration (Cmax) ranged from 2370.87–5475.77 hour*ng/ml and 606.07–1348.86 ng/ml, respectively. The most common EVER4010001‐related treatment‐emergent adverse events were diarrhea (94.7%), increased aspartate aminotransferase (57.9%), and increased alanine aminotransferase (47.4%).ConclusionEighty milligrams BID was the MTD and RP2D for EVER4010001 plus pembrolizumab. Efficacy results were promising, and no new safety risks were reported, justifying the Phase 2 portion of this study.
A study of preferred and natural memory colours across different ethnic groups
Authors: Cao Mingkai , Luo Ming Ronnier , Lu Yan , Xaio Kaida 
Published: January 2023

AbstractA psychophysical experiment was carried out to specify the preferred and natural memory colours corresponding to 24 familiar objects on mobile displays. These objects were selected to cover a large colour gamut in CIELAB space. One hundred and six observers from five different ethnic groups participated. Forty‐nine colours for each object were rendered three‐dimensionally to cover a large colour range. The results showed inter‐observer variations are small between different ethnic groups, about 1.4 and 1.3 CIEDE2000 colour difference units for naturalness and preference, respectively. Comparing the preference and the naturalness colour centres, the preferred colours are brighter and more colourful than naturalness colours, by 1 and 2 units in L* and C*ab attributes, respectively. Both sets of data show a great hue consistency. The results showed that different ethnic groups agreed well on the objects studied. It was found that the best‐agreed objects are strawberry, green apple, tomato, corn and purple grape, and the worst‐agreed objects are blueberry, broccoli, smurf, green pepper and blue sky.
The efficacy and safety of a duckbill‐type anti‐reflux metal stent as the initial metal stent for distal malignant biliary obstruction in unresectable pancreatic cancer
Authors: Takeda Tsuyoshi , Sasaki Takashi , Yamada Yuto , Okamoto Takeshi , Mie Takafumi , Furukawa Takaaki , Kasuga Akiyoshi , Matsuyama Masato , Ozaka Masato , Sasahira Naoki 
Published: January 2023

AbstractBackgroundThe usefulness of duckbill‐type anti‐reflux metal stent (DMS) in self‐expandable metal stent‐naïve pancreatic cancer (PC) patients has not been well‐studied. This study aimed to evaluate the efficacy and safety of DMS in such patients.MethodsWe analyzed consecutive patients with unresectable PC who received a covered metal stent (CMS) as the initial self‐expandable metal stent at our institution. Technical success, functional success, causes of recurrent biliary obstruction (RBO), time to RBO (TRBO), adverse events (AEs), and reintervention rates were compared between DMS and conventional CMS (c‐CMS).ResultsA total of 69 patients were included (DMS: 28, c‐CMS: 41). Technical success, functional success, and AEs were similar between groups. Tumor ingrowth was more common in the DMS group (18% vs. 0%, p = 0.009), while non‐occlusion cholangitis tended to be more common in the c‐CMS group (0% vs. 15%, p = 0.074). Median time to RBO was similar between groups (276 vs. 273 days, p = 0.915). The anti‐reflux valve of DMS was found torn in 56% of patients. Endoscopic reintervention was successful in all cases, despite failed stent removal in 88% of patients in the DMS group.ConclusionsDMS was not associated with longer time to RBO compared to c‐CMS in self‐expandable metal stent‐naïve patients.
Seismic analysis of 3D train–wheel–bridge–bearing systems: Modeling
Authors: Li Hong‐Wei , Xu Zhao‐Dong , Gomez Daniel , Dyke Shirley J. , Ni Yi‐Qing , Wang You‐Wu 
Published: January 2023

AbstractBearing effects have not been deeply investigated in the dynamic analysis of a train–bridge coupled system subjected to earthquake motions, and existing studies on base isolation of railway bridges have typically not considered the running train. To fill these gaps, this paper develops the numerical model of a three‐dimensional train–wheel–bridge–bearing (TWBB) system for seismic analysis. The substructuring method is implemented to separate the TWBB system into the train, wheel–rail, bridge and bearing subsystems, and couple them using state‐space representations. The complete model of the TWBB system has three main features: fewer degrees of freedom (DOF) than traditional finite element methods, applicability to different types of bearings, and simplicity as no iterations in the simulation are required. Therefore, the proposed procedure demonstrates that the TWBB model is an efficient and flexible representation to obtain and predict realistic demands for engineering purposes.