bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paraneoplastic arthritis: a series of 92 cases
Authors: Kısacık Bünyamin , Albayrak Fatih , Balcı Mehmet Ali , Koc Emrah 
Published: September 2023

Abstract

Objectives
Paraneoplastic arthritis (PA) is one of the paraneoplastic syndromes. Both laboratory and clinical findings similar to rheumatological diseases can be seen. In this study we aimed to present the clinical and laboratory findings, malignancy types and pathological diagnoses of patients with paraneoplastic arthritis.

Methods
In a multicentre retrospective study, 92 patients with PA from the last 10 years were included.

Results
Patients with PA and haematological malignancies exhibited the highest ratio of lymphomas (25.6%). The most common cancer detected in patients with solid malignancy and PA was lung cancer (41.5%). All malignant patients with PA had significant anti-CCP positivity compared with the healthy control group (P = 0.014).

Conclusion
Although PA is a rare condition, it can be confused with many rheumatological diseases. The most commonly involved joint is the knee joint, followed by the ankle and hand/wrist. Autoantibody negativity, high lactate dehydrogenase level and arthritis unresponsive to treatment constitute important clues for diagnosis.
Determinants of health-related quality of life and global functioning and health in axSpA, pSpA and PsA: results from the ASAS-PerSpA study
Authors: Santos Helena , Henriques Ana R , Machado Pedro M , Lopez-Medina Clementina , Dougados Maxime , Canhão Helena , Rodrigues Ana M , Pimentel-Santos Fernando 
Published: September 2023

Abstract

Objectives
We aimed to identify determinants of health-related quality of life (HRQoL) and global functioning and health (GH) in axial SpA (axSpA), peripheral SpA (pSpA) and (PsA).

Methods
The ASAS-perSpA study data were analysed. Models for the three patient groups were run separately to explore factors associated with HRQoL and GH, assessed by EQ-5D and ASAS-HI, respectively.

Results
The analyses included 4185 patients: 2719 with axSpA, 433 with pSpA, and 1033 with PsA.
In axSpA, disease activity (β = –0.061), physical function (β = –0.041), female sex (β = –0.019) and fibromyalgia (FM) (β = –0.068) were associated with worse HRQoL; age (β = 0.001) and university education (β = 0.014) were associated with better HRQoL. In pSpA, disease activity (β = –0.04) and physical function (β = –0.054) were associated with worse HRQoL. In PsA, disease activity (β = –0.045), physical function (β = –0.053), axial disease (β = –0.041) and female sex (β = –0.028) were associated with worse HRQoL. In axSpA, disease activity (β = 0.889), physical function (β = 0.887), peripheral disease (β = 0.564), female sex (β = 0.812) and FM (β = 1.639) were associated with worse GH; age (β = –0.013) and university education (β = –0.274) were associated with better GH. In pSpA, physical function (β = 1.142) and female sex (β = 1.060) were associated with worse GH; university education (β = –0.611) was associated with better GH. In PsA, disease activity (β = 0.703), physical function (β = 1.025), axial involvement (β = 0.659), female sex (β = 0.924) and FM (β = 1.387) were associated with worse GH; age (β = –0.024) and university education (β = –0.856) were associated with better GH.

Conclusion
Disease activity and physical function are major HRQoL and GH determinants across SpA types, and clinical characteristics and sociodemographic factors play an important role, highlighting the importance of a holistic approach for individual patients.
The relationship between mean glandular dose and compressed breast thickness specified for Jordan
Authors: Ahmed Shaker Hegian Zeinab , Moh’d Abu Tahoun Laila , Ramli Ramzun Maizan , Noor Azman Nurul Zahirah 
Published: September 2023

Abstract
The mean glandular dose (MGD) is a measurement used in mammography to assess the amount of radiation absorbed. By considering specific exposure radiation dose criteria, MGD ensures minimal radiation while maintaining image quality for detecting abnormalities. The relationship between MGD and compressed breast thickness (CBT) is commonly utilized in mammographic dose surveys. This study aims to estimate the MGD-CBT relationship based on patient age in Jordan through retrospective analysis. The analysis involved 3465 screening mammography images of women aged 40–80, divided into three age groups: 40–49, 50–64 and 65–80 years. Each group had a specific CBT range (16.5–156 mm). The results indicate that MGD ranges from 1.6 to 1.7 mGy across all three age groups, independent of CBT. Thus, a significant and positive correlation exists between MGD and CBT in all age groups.
Sleep deprivation and aging are metabolically linked across tissues
Authors: Sengupta Arjun , Tudor Jennifer C , Cusmano Danielle , Baur Joseph A , Abel Ted , Weljie Aalim M 
Published: September 2023

Abstract

Study objectives
Insufficient sleep is a concerning hallmark of modern society because sleep deprivation (SD) is a risk factor for neurodegenerative and cardiometabolic disorders. SD imparts an aging-like effect on learning and memory, although little is known about possible common molecular underpinnings of SD and aging. Here, we examine this question by profiling metabolic features across different tissues after acute SD in young adult and aged mice.

Methods
Young adult and aged mice were subjected to acute SD for 5 hours. Blood plasma, hippocampus, and liver samples were subjected to UPLC-MS/MS-based metabolic profiling.

Results
SD preferentially impacts peripheral plasma and liver profiles (e.g. ketone body metabolism) whereas the hippocampus is more impacted by aging. We further demonstrate that aged animals exhibit SD-like metabolic features at baseline. Hepatic alterations include parallel changes in nicotinamide metabolism between aging and SD in young animals. Overall, metabolism in young adult animals is more impacted by SD, which in turn induces aging-like features. A set of nine metabolites was classified (79% correct) based on age and sleep status across all four groups.

Conclusions
Our metabolic observations demonstrate striking parallels to previous observations in studies of learning and memory and define a molecular metabolic signature of sleep loss and aging.
Sleep regularity is a stronger predictor of mortality risk than sleep duration: A prospective cohort study
Authors: Windred Daniel P , Burns Angus C , Lane Jacqueline M , Saxena Richa , Rutter Martin K , Cain Sean W , Phillips Andrew J K 
Published: September 2023

Abstract
Abnormally short and long sleep are associated with premature mortality, and achieving optimal sleep duration has been the focus of sleep health guidelines. Emerging research demonstrates that sleep regularity, the day-to-day consistency of sleep–wake timing, can be a stronger predictor for some health outcomes than sleep duration. The role of sleep regularity in mortality, however, has not been investigated in a large cohort with objective data. We therefore aimed to compare how sleep regularity and duration predicted risk for all-cause and cause-specific mortality. We calculated Sleep Regularity Index (SRI) scores from &gt; 10 million hours of accelerometer data in 60 977 UK Biobank participants (62.8 ± 7.8 years, 55.0% female, median[IQR] SRI: 81.0[73.8–86.3]). Mortality was reported up to 7.8 years after accelerometer recording in 1859 participants (4.84 deaths per 1000 person-years, mean (±SD) follow-up of 6.30 ± 0.83 years). Higher sleep regularity was associated with a 20%–48% lower risk of all-cause mortality (p &lt; .001 to p = 0.004), a 16%–39% lower risk of cancer mortality (p &lt; 0.001 to p = 0.017), and a 22%–57% lower risk of cardiometabolic mortality (p &lt; 0.001 to p = 0.048), across the top four SRI quintiles compared to the least regular quintile. Results were adjusted for age, sex, ethnicity, and sociodemographic, lifestyle, and health factors. Sleep regularity was a stronger predictor of all-cause mortality than sleep duration, by comparing equivalent mortality models, and by comparing nested SRI-mortality models with and without sleep duration (p = 0.14–0.20). These findings indicate that sleep regularity is an important predictor of mortality risk and is a stronger predictor than sleep duration. Sleep regularity may be a simple, effective target for improving general health and survival.
Why Not Mahan? Path Dependence in Modern Japanese Geostrategic Thinking of the Pacific
Authors: HARUNA Nobuo 
Published: September 2023

Abstract
It is well known that during the 1930s and the 1940s intellectuals in Japan, an island state, devoured geopolitical theories constructed in a typical ‘land power’, Germany. Not only did this fad contradict the geographical reality of Japanese territory. It was also at odds with Japan’s contemporary national identity as a maritime state. This article highlights intellectual path dependence as the key to explaining this conundrum. The initial decision that paved the way for the adoption of the German tradition of geopolitics was made shortly before the outbreak of the Russo-Japanese War by political scientist Onozuka Kiheiji, who consciously opted for the geographical ideas of Friedrich Ratzel instead of the naval strategy of Alfred Thayer Mahan as a theoretical guide and justification for empire-building. This article illustrates how the choice made by Onozuka induced his students, who became leading intellectual figures after World War I, to follow the evolution of German geopolitics and to propagate the ideas of Karl Haushofer at the beginning of the Pacific War. The article ends by briefly describing how the Geopolitik tradition was overcome by the formation of a new maritime national identity after the war.
Efficacy of Umbilical Cord-Derived Mesenchymal Stem Cells in the Treatment of Type 2 Diabetes Assessed by Retrospective Continuous Glucose Monitoring
Authors: Zang Li , Li Yijun , Hao Haojie , Liu Jiejie , Zhang Qian , Gao Fei , Wang Haibin , Chen Yulong , Gu Weijun , Du Jin , Meng Junhua , Zhang Saichun , Lyu Zhaohui , Dou Jingtao , Mu Yiming 
Published: September 2023

Abstract
Umbilical cord-derived mesenchymal stem cells (UC-MSCs) have been proved a promising clinical strategy for the treatment of diabetes, and time in range (TIR) has been demonstrated a new metric of glycemic control links to diabetes complications. To further assess the therapeutic effect of UC-MSCs on TIR, a phase II study investigating the efficacy of UC-MSCs in Chinese adults with type 2 diabetes (T2D) assessed by retrospective continuous glucose monitoring (CGM) was conducted. In this randomized and placebo-controlled trial, a total of 73 patients were randomly assigned to receive intravenous infusion of UC-MSCs (n = 37) or placebo (n = 36) 3 times at 4-week intervals and followed up for 48 weeks. The primary endpoint was the changes in TIR and glycosylated hemoglobin (HbA1c). TIR and HbA1c were both significantly improved in UC-MSCs and placebo groups after 48 weeks of therapy compared with baseline. Compared with placebo group, UC-MSCs group exhibited more pronounced changes at 9 and 48 weeks from baseline in TIR (26.54 vs. 15.84 and 21.36 vs. 6.32) and HbA1c (−1.79 vs. −0.96 and −1.36 vs. −0.51). More patients in UC-MSCs group achieved the glycemic control target of TIR ≥ 70% and HbA1c &lt; 7% at 9 and 48 weeks than in placebo group (59.5% vs. 27.8% and 43.2% vs. 11.1%). The C-peptide area under the curve (AUCC-pep) was an independent risk factor associated with efficacy in T2D undergoing UC-MSCs intervention. These results illustrate that UC-MSCs administration via intravenous infusion is an effective approach for ameliorating TIR.
The Relationship between Lifetime Opioid Use and Mental and Physical Health among Incarcerated Individuals
Authors: Renn Tanya , Moore John Randolph , Veeh Christopher , Pettus Carrie 
Published: September 2023

AbstractRelationships between opioid use and health, both physical and mental, have been discovered over the last decade or so, but these relationships have yet to be explored among incarcerated individuals. These relationships are important as they may have implications on the health of those who are incarcerated and nearing reentry, because higher rates of opioid use, as well as poor physical and mental health, are found among those who are justice-involved compared with the general population. Using baseline data from a multistate randomized controlled trial, authors aimed to fill this gap by exploring mental health disorder rates and physical health among a sample of incarcerated individuals who report lifetime opioid use and nearing community reentry. Results showed that the prevalence of lifetime opioid use was significantly associated with increased physical role limitation, decreased emotional well-being, and overall poorer health. Additionally, individuals with a lifetime history of opioid use were significantly more likely to have depression, social and generalized anxiety disorders, as well as a history of alcohol and illicit substance use. This work speaks to the urgency in expanding efforts to increase access to comprehensive service delivery models that address substance use, mental health, and physical health comorbidities among incarcerated individuals.
Juniperus virginiana sourced from colder climates maintain higher ratios of soluble sugars to starch during cold acclimation
Authors: Harbol Samuel C , Long Randall W , Medeiros Juliana S 
Published: September 2023

Abstract
Nonstructural carbohydrates (NSCs) are carbon compounds that serve a large variety of purposes, which makes it hard to disentangle how their concentrations change in response to environmental stress. Soluble sugars can accumulate in plants as metabolic demand decreases, e.g., in response to drought or as seasonal temperatures decrease. Alternatively, actively allocating to NSCs could be beneficial in cold acclimation (CA) or in periods of increased aridity because soluble sugars serve non-metabolic functions as cryoprotectants and in osmoregulation. We used Juniperus virginiana L., a woody plant currently expanding its range, to investigate whether plants sourced from colder and more arid locations maintained higher concentrations of NSCs. We sourced three populations of J. virginiana from across an environmental gradient, and we compared these with the closely related Juniperus scopulorum Sarg. We grew the plants in a common garden in north-east OH, part of J. virginiana’s historic range. We exposed the plants to a drought treatment during the summer and then measured the NSC concentrations and cold-hardiness as the plants acclimated to colder temperatures and shorter days. We found that individuals originating from the warmer, more southern range edge were initially not as cold-hardy as plants from the other source populations and that they only reached similar hardiness after prolonged low temperatures. We did not find an effect of drought on NSCs, although this may be due to other traits conferring a high level of drought tolerance in J. virginiana. Across all plants, the NSC concentration increased over the CA period, specifically as sugars. Although the highest concentrations of sugars were found in plants from southern populations, the plants from colder environments maintained higher sugar-to-starch ratios. These results highlight the importance of NSCs in CA and that plants sourced from different climates showed different physiological responses to shortening days and low temperatures.
Ca2+- and Zn2+-dependent nucleases co-participate in nuclear DNA degradation during programmed cell death in secretory cavity development in Citrus fruits
Authors: Liang Minjian , Huai Bin , Lin Junjun , Liang Xiangxiu , He Hanjun , Bai Mei , Wu Hong 
Published: September 2023

Abstract
Calcium (Ca2+)- and zinc Zn2+-dependent nucleases play pivotal roles in plant nuclear DNA degradation in programmed cell death (PCD). However, the mechanisms by which these two nucleases co-participate in PCD-associated nuclear DNA degradation remain unclear. Here, the spatiotemporal expression patterns of two nucleases (CrCAN and CrENDO1) were analyzed qualitatively and quantitatively during PCD in secretory cavity formation in Citrus reticulata ‘Chachi’ fruits. Results show that the middle and late initial cell stages and lumen-forming stages are key stages for nuclear degradation during the secretory cavity development. CAN and ENDO1 exhibited potent in vitro DNA degradation activity at pH 8.0 and pH 5.5, respectively. Quantitative real-time reverse-transcription polymerase chain reaction, in situ hybridization assays, the subcellular localization of Ca2+ and Zn2+, and immunocytochemical localization showed that CrCAN was activated at the middle and late initial cell stages, while CrENDO1 was activated at the late initial cell and lumen-forming stages. Furthermore, we used immunocytochemical double-labelling to simultaneously locate CrCAN and CrENDO1. The DNA degradation activity of the two nucleases was verified by simulating the change of intracellular pH in vitro. Our results also showed that CrCAN and CrENDO1 worked respectively and co-participated in nuclear DNA degradation during PCD of secretory cavity cells. In conclusion, we propose the model for the synergistic effect of Ca2+- and Zn2+-dependent nucleases (CrCAN and CrENDO1) in co-participating in nuclear DNA degradation during secretory cavity cell PCD in Citrus fruits. Our findings provide direct experimental evidence for exploring different ion-dependent nucleases involved in nuclear degradation during plant PCD.
Filling the “Decency Gap”? Donors’ Reaction to US Policy on International Family Planning Aid
Authors: Ferrière Nathalie 
Published: September 2023

Abstract
The impact of US allocation of family planning aid on other donors is studied in order to gain new insights into donor interactions. Within this context, the dominant player in the sector is the United States, whose policies on family planning undergo changes influenced by domestic debates surrounding abortion. By utilizing the Mexico City Policy and considering exposure to this particular policy as an instrumental factor, it has been observed that other donors do not immediately react to policy changes made by the United States, either contemporaneously or within one year. However, a noticeable shift occurs after a two-year period, indicating that these donors eventually align their allocation strategies with those of the United States. Further analysis of this phenomenon reveals varying patterns among different types of donors. While smaller donors exhibit a clear intention to compensate for US policy changes, larger donors display a mix of competitive tendencies and herding behavior, thereby reinforcing the impact of the Mexico City Policy after the two-year time frame.
E3ubiquitin ligaseRNF187promotes growth of spermatogonia via lysine 48‐linked polyubiquitination‐mediated degradation ofKRT36/KRT84
Authors: Yu Xiangling , Xu Bingya , Gao Tingting , Fu Xu , Jiang Bing , Zhou Nianchao , Gao Wenxin , Wu Tiantian , Shen Cong , Huang Xiaoyan , Wu Yibo , Zheng Bo 
Published: September 2023

AbstractUbiquitination is the most common post‐translational modification and is essential for various cellular regulatory processes. RNF187, which is known as RING domain AP1 coactivator‐1, is a member of the RING finger family. RNF187 can promote the proliferation and migration of various tumor cells. However, whether it has a similar role in regulating spermatogonia is not clear. This study explored the role and molecular mechanism of RNF187 in a mouse spermatogonia cell line (GC‐1). We found that RNF187 knockdown reduced the proliferation and migration of GC‐1 cells and promoted their apoptosis. RNF187 overexpression significantly increased the proliferation and migration of GC‐1 cells. In addition, we identified Keratin36/Keratin84 (KRT36/KRT84) as interactors with RNF187 by co‐immunoprecipitation and mass spectrometry analyses. RNF187 promoted GC‐1 cell growth by degrading KRT36/KRT84 via lysine 48‐linked polyubiquitination. Subsequently, we found that KRT36 or KRT84 overexpression significantly attenuated proliferation and migration of RNF187‐overexpressing GC‐1 cells. In summary, our study explored the involvement of RNF187 in regulating the growth of spermatogonia via lysine 48‐linked polyubiquitination‐mediated degradation of KRT36/KRT84. This may provide a promising new strategy for treating infertility caused by abnormal spermatogonia development.
Single-Use Reamer Shafts for Intramedullary Nail Fixation: An Addressable Source of Extraneous Cost and Medical Waste in Orthopaedic Surgery
Authors: Pesante Ben D , Stacey Stephen C , Kim Ye Joon , Parry Joshua A 
Published: September 2023

Abstract

Objectives:
To analyze the impact of switching from single-use reamer shafts to reusable reamer shafts for intramedullary nail fixation (IMN) of femur and tibia fractures at a single level-one trauma center, in terms of cost, metal waste, and infection rates.

Design:
Retrospective comparison study

Setting:
Level one trauma center
Patients/Participants: Patients with operative femur and tibia fractures treated before and after adoption of a reusable reamer shaft.

Intervention:
Reamed IMN fixation

Main Outcome Measurements:
Reductions in cost ($292 per shaft) and metal waste (0.44 pounds (lbs) per reamer shaft; reamer shaft failure (breakage and/or incarceration); superficial and deep infections

Results:
A single surgeon treated 125 and 135 fractures before and after adoption of a reusable reamer shaft. No reamer shaft failures were identified. The before and after groups did not differ in age, OTA/AO classification, or infection rates. By adopting reusable reamer shafts the surgeon avoided an estimated 54 single-use reamer shafts per year for an estimated cost and metal waste savings per year of $15,643 USD and 24 lbs. Over the same time period that the surgeon switched to using reusable reamer shafts, a total of 283 single-use reamer shafts were utilized by 12 surgeons in the same department. If the entire department had adopted reusable reamer shafts during that time period an estimated 164 reamer shafts per year would have been avoided for a total cost and metal waste savings per year of $47,763 USD and 72 lbs.

Discussion:
Single-use reamer shafts represent an easily addressable source of extraneous cost and metal waste in orthopaedic surgery.

Level of Evidence:
Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.