bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiological Roles of Hippo Signaling Pathway and Autophagy in
Dementia
Authors: Christoper Andreas , Herman Herry , Abdulah Rizky , Zulhendri Felix , Sanjaya Ardo , Lesmana Ronny 
Published: February 2023

Background:
Dementia is a neurocognitive disorder associated with the aging brain and
mainly affects the hippocampus and cerebral cortex. The Hippo signaling pathway and autophagy
proteins have been found to be perturbed in the brain affected by dementia processes.

Objective:
This systematic review aims to elaborate on the involvement of the Hippo signaling
pathway and autophagy in modulating the progression and severity of dementia in aging.

Methods:
Searches were conducted on MEDLINE, Google Scholar, Scopus, and Web of Science
databases.

Results:
The Hippo signaling pathway is dependent upon the transcriptional co-activator
YAP/TAZ, which forms complexes with TEAD in the nucleus in order to maintain cell homeostasis.
When the expression YAP/TAZ is reduced, transcriptional repression-induced atypical cell
death, ballooning cell death, and necrosis will consequently occur in the neurons. Moreover, the
autophagic proteins, such as LC3, ATG proteins, and Beclin, are reduced, resulting in the disruption
of autophagosome formation and accumulation and the spread of misfolded proteins in the brain
suffering from dementia.

Conclusion:
The impairment of the Hippo signaling pathway and autophagy in the dementia process
in aging should be considered since it might predict the severity, treatment, and prevention of
dementia.
Medicinal Plants used Traditionally in Sudan to Treat Viral Infections
Related to the Signs and Symptoms of COVID-19: A Systematic Review
Authors: Yagi Sakina , Yagi Ahmed 
Published: February 2023

Background:
The rapid global spread of the COVID-19 pandemic urged scientists to
search for effective and safe anti-coronavirus drugs from natural resources. Through centuries, traditional
medicinal plants have been providing cure for diseases and general health care worldwide.

Objective:
The main aim of this review was to explore and summarize the research works on the different
plants used traditionally in Sudan to treat signs and symptoms of COVID-19 and respiratory diseases,
characterizing their antiviral activities and exploring the different phytochemicals present in these plants.

Method:
The current review was carried out in line with the recommendations of the PRISMA
2020 statement. Information on plants traditionally used in Sudan to treat the signs and symptoms
of COVID-19 and respiratory diseases was obtained from traditional medicine books and published
articles, as well as the daily practice by ordinary people.

Results:
This article illustrated the use of 27 plant species belonging to 15 families in Sudanese traditional
medicine to treat signs and symptoms of COVID-19 and respiratory diseases. Leguminosae/
Fabaceae was found to be the most represented family (7 species), followed by Combretaceae
(3 species) and Capparidaceae and Malvaceae (2 species each). From these plants, about 11 plant
species were studied for their antiviral activity against at least one virus, and 5 plants, namely Adansonia
digitata, Boscia senegalensis, Hibiscus sabdariffa, Nigella sativa, and Mangifera indica, were
tested for their antiviral activity against influenza viruses. The phytoconstituents of the listed plants
were summarized, and the antiviral activity of their isolated bioactive compounds was highlighted.

Conclusion:
The review could provide an in-depth theoretical basis and valuable data for designing
future studies.
Influence of User Profile Attributes on e-Cigarette–Related Searches on YouTube: Machine Learning Clustering and Classification
Authors: Murthy Dhiraj , Lee Juhan , Dashtian Hassan , Kong Grace 
Published: February 2023

Background
The proliferation of e-cigarette content on YouTube is concerning because of its possible effect on youth use behaviors. YouTube has a personalized search and recommendation algorithm that derives attributes from a user’s profile, such as age and sex. However, little is known about whether e-cigarette content is shown differently based on user characteristics.

Objective
The aim of this study was to understand the influence of age and sex attributes of user profiles on e-cigarette–related YouTube search results.

Methods
We created 16 fictitious YouTube profiles with ages of 16 and 24 years, sex (female and male), and ethnicity/race to search for 18 e-cigarette–related search terms. We used unsupervised (k-means clustering and classification) and supervised (graph convolutional network) machine learning and network analysis to characterize the variation in the search results of each profile. We further examined whether user attributes may play a role in e-cigarette–related content exposure by using networks and degree centrality.

Results
We analyzed 4201 nonduplicate videos. Our k-means clustering suggested that the videos could be clustered into 3 categories. The graph convolutional network achieved high accuracy (0.72). Videos were classified based on content into 4 categories: product review (49.3%), health information (15.1%), instruction (26.9%), and other (8.5%). Underage users were exposed mostly to instructional videos (37.5%), with some indication that more female 16-year-old profiles were exposed to this content, while young adult age groups (24 years) were exposed mostly to product review videos (39.2%).

Conclusions
Our results indicate that demographic attributes factor into YouTube’s algorithmic systems in the context of e-cigarette–related queries on YouTube. Specifically, differences in the age and sex attributes of user profiles do result in variance in both the videos presented in YouTube search results as well as in the types of these videos. We find that underage profiles were exposed to e-cigarette content despite YouTube’s age-restriction policy that ostensibly prohibits certain e-cigarette content. Greater enforcement of policies to restrict youth access to e-cigarette content is needed.
Understanding Transgender and Gender-Diverse Youth’s Experiences Receiving Care via Telemedicine: Qualitative Interview Study
Authors: Kahn Nicole F , Anan Yomna H , Bocek Kevin M , Christakis Dimitri A , Richardson Laura P , Pratt Wanda , Sequeira Gina M 
Published: February 2023

Background
Access to virtual care has increased since the beginning of the COVID-19 pandemic, yet little is known about transgender and gender-diverse (TGD) youth’s experiences and perspectives on receiving care via telemedicine.

Objective
The purpose of this study was to explore these experiences to (1) inform necessary changes to the provision of pediatric gender-affirming care and (2) help providers and health systems determine if and how telemedicine should be made available post pandemic.

Methods
Youth (aged 14-17 years) who completed a telemedicine visit in the Seattle Children’s Gender Clinic were invited to participate in a semistructured interview exploring perceived advantages or disadvantages of telemedicine and preferred visit modalities. Interview transcriptions were analyzed by 2 research team members using an inductive thematic analysis framework.

Results
A total of 15 TGD youth completed an interview. Commonly cited advantages of telemedicine were convenience and comfort with having visits in their own environments. Reported disadvantages included technical issues, discomfort with the impersonal nature, lack of familiarity with the platform, and privacy concerns. Overall, slightly more youth preferred in-person visits over telemedicine, referencing both specific characteristics of the clinical visit (ie, initial vs return and complexity) and proximity to the clinic as reasons for this preference. Although a plurality of TGD youth preferred in-person visits, they also recognized the value of telemedicine and the impact it may have in facilitating access to care.

Conclusions
Given the variations in needs and visit complexity, our study supports the provision of both in-person and telemedicine modalities as options for pediatric gender-affirming care.
A Relational Agent Intervention for Adolescents Seeking Mental Health Treatment: Protocol for a Randomized Controlled Trial
Authors: Chiauzzi Emil , Robinson Athena , Martin Kate , Petersen Carl , Wells Nicole , Williams Andre , Gleason Mary Margaret 
Published: February 2023

Background
Unmet pediatric mental health (MH) needs are growing as rates of pediatric depression and anxiety dramatically increase. Access to care is limited by multiple factors, including a shortage of clinicians trained in developmentally specific, evidence-based services. Novel approaches to MH care delivery, including technology-leveraged and readily accessible options, need to be evaluated in service of expanding evidence-based services to youths and their families. Preliminary evidence supports the use of Woebot, a relational agent that digitally delivers guided cognitive behavioral therapy (CBT) through a mobile app, for adults with MH concerns. However, no studies have evaluated the feasibility and acceptability of such app-delivered relational agents specifically for adolescents with depression and/or anxiety within an outpatient MH clinic, nor compared them to other MH support services.

Objective
This paper describes the protocol for a randomized controlled trial evaluating the feasibility and acceptability of an investigational device, Woebot for Adolescents (W-GenZD), within an outpatient MH clinic for youths presenting with depression and/or anxiety. The study’s secondary aim will compare the clinical outcomes of self-reported depressive symptoms with W-GenZD and a telehealth-delivered CBT-based skills group (CBT-group). Tertiary aims will evaluate additional clinical outcomes and therapeutic alliance between adolescents in W-GenZD and the CBT-group.

Methods
Participants include youths aged 13-17 years with depression and/or anxiety seeking care from an outpatient MH clinic at a children’s hospital. Eligible youths will have no recent safety concerns or complex comorbid clinical diagnoses; have no concurrent individual therapy; and, if on medications, are on stable doses, based on clinical screening and as well as study-specific criteria.

Results
Recruitment began in May 2022. As of December 8, 2022, we have randomized 133 participants.

Conclusions
Establishing the feasibility and acceptability of W-GenZD within an outpatient MH clinical setting will add to the field’s current understanding of the utility and implementation considerations of this MH care service modality. The study will also evaluate the noninferiority of W-GenZD against the CBT-group. Findings may also have implications for patients, families, and providers looking for additional MH support options for adolescents seeking help for their depression and/or anxiety. Such options expand the menu of supports for youths with lower-intensity needs as well as possibly reduce waitlists and optimize clinician deployment toward more severe cases.

Trial Registration
ClinicalTrials.gov NCT05372913; https://clinicaltrials.gov/ct2/show/NCT05372913

International Registered Report Identifier (IRRID)
DERR1-10.2196/44940
Uji organoleptis kualitas teh berbahan dasar bunga belimbing wuluh
Authors: Sugiarmawan I Kadek Edi 
Published: February 2023

Teh adalah suatu minuman yang memiliki rasa yang sangat spesifik dan sangat di minati oleh masyarakat Indonesia. Proses pembuatan teh ini menggunakan teknik penjemuran langsung dengan bantuan sinar matahari. Melihat pengolahan teh yang semakin maju namun kurangnya inovasi bahan lokal dalam pembuatannya, mendorong penulis untuk mencari bahan lokal pembuat teh yang dipandang sebelah mata namun memiliki banyak sekali khasiat yang sangat baik bagi tubuh manusia. Tujuan penelitian ini untuk mengetahui kualitas teh dari segi rasa, aroma, warna dan mengetahui berapa lama teh dapat disimpan atau dikonsumsi. Tempat penelitian ini berada di Mano Beach House, Jl. Pantai Pura Petitenget Krobokan Kelod, Seminyak, Kec, Kuta Utara, Kabupaten Badung, Bali. Penelitian akan dilakukan dari bulan Februari– Mei 2021. Metode yang digunakan dengan cara mengumpulkan data dengan kuisioner dan observasi. Teknik analisa data dengan menberikan kuisioner kepada 30 orang panelis dari segi rasa, aroma, dan warna. Berdasarkan hasil persentase data yang di ujikan kepada 30 panelis menyatakan 10% menyatakan sangat enak, 13% menyatakan cukup enak, 39% menyatakan cukup enak, 13% menyatakan tidak enak, 25% menyatakan kurang enak. Dan memiliki daya tahan selama 1 hari dihari ke 2 indikator rasa, warna, dan aroma menghilang.

Tea is a drink that has a very specific taste and is of great interest to the people of Indonesia. The process of making this tea uses direct drying techniques with the help of sunlight. Seeing the progress of tea processing but the lack of innovation from local ingredients in its manufacture, prompted the author to look for local tea-making ingredients that are underestimated but have many excellent properties for the human body. The purpose of this study was to determine the quality of tea in terms of taste, aroma, color and to find out how long tea can be stored or consumed. The place of this research is at Mano Beach House, Jl. Petitenget Krobokan Kelod Temple Beach, Seminyak, Kec, North Kuta, Badung Regency, Bali. The research will be conducted from February to May 2021. The method used is to collect data using questionnaires and observations. Data analysis technique by giving questionnaires to 30 panelists in terms of taste, aroma and color. Based on the results of the percentage of data tested on 30 panelists, 10% said it was very good, 13% said it was quite good, 39% said it was quite good, 13% said it was not good, 25% said it was not good. And it has a durability of 1 day on the 2nd day the taste, color and aroma indicators disappear.
Pemanfaatan buah nanas dalam pembuatan popcorn
Authors: Adithya Putu Bagus Roland 
Published: February 2023

Popcron merupakan makanan ringan / snack siap saji yang pada umumnya dijual di pasaran yang dibuat dengan bahan dasar biji jagung olahan dengan varian rasa salty,karamel, keju dan coklat. Peneliti melakukan eksperimen dengan memanfaatkan buah nanas sebagai varian rasa dalam pembuatan popcorn. Penelitian dilaksanakan pada bulan mei 2021 hingga Agustus 2021. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana kualitas popcorn dengan rasa buah nanas dari segi rasa, aroma, tekstur dan warna. Dalam data ini menggunakan analisis uji organoleptik dengan responden sebanyak 30 responden. Hasil yang diperoleh yaitu dari segi warna popcorn rasa nanas mendapatkan skor sebesar 125 , dari segi rasa popcorn rasa nanas mendapatkan skor sebesar 122, dari segi aroma popcorn rasa nanas mendapatkan skor sebesar 124 dan dari segi tekstur popcorn rasa nanas mendapatkan skor sebesar 138. Untuk daya tahan popcorn rasa nanas dapat bertahan dalam suhu ruangan selama 2 hari saat sudah melalui proses memasak. Untuk biaya pembuatan popcorn dengan rasa buah nanas adalah sebesar Rp. 16.410 untuk pembuatan 1 box popcorn yang dapat menampung 100 gram popcorn

Popcron is a ready-to-eat snack / snack that is generally sold in the market which is made with the basic ingredients of processed corn kernels with variants of salty, caramel, cheese and chocolate flavors. Researchers conducted experiments by using pineapple as a flavor variant in making popcorn. The research was conducted from May 2021 to August 2021. The purpose of this study was to determine the quality of popcorn with pineapple flavor in terms of taste, aroma, texture and color. This data uses organoleptic test analysis with 30 respondents. The results obtained are in terms of color, pineapple-flavored popcorn, a score of 125, in terms of taste, pineapple- flavored popcorn, a score of 122, in terms of aroma, pineapple-flavored popcorn, a score of 124, and in terms of texture, pineapple-flavored popcorn, a score of 138. pineapple-flavored popcorn can last at room temperature for 2 days after it has gone through the cooking process. The cost of making popcorn with pineapple flavor is Rp. 16,410 for the manufacture of 1 popcorn box that can hold 100 grams of popcorn
Pengaruh promosi jabatan dan kompensasi terhadap kinerja karyawan di pizza hut sunset road point
Authors: Sentanu I Nyoman Tri Mulya , Mahendra I Wayan Eka , Sulasmini Ni Made Ayu 
Published: February 2023

Penelitian ini bertujuan untuk mengetahui pengaruh promosi jabatan, dan kompensasi secara parsial dan simultan terhadap kinerja karyawan di Pizza Hut Cabang Sunset Road Point Bali. Lokasi penelitian ini di Pizza Hut Cabang Sunset Road Point Bali. Sampel yang digunakan dalam penelitian ini sebanyak 40 responden. Teknik analisis data yang digunakan dalam penelitian ini adalah Uji Asumsi Klasik, Analisis Regresi Linier Berganda, Uji Koefisien Determinasi, Uji F dan Uji t. Dari hasil penelitian dapat dilihat bahwa: (1) promosi jabatan berpengaruh positif signifikan terhadap kinerja karyawan, dimana diperoleh nilai t-hitung 3,028 dan signifikansi 0,004. (2) kompensasi berpengaruh positif signifikan terhadap kinerja karyawan, dimana diperoleh nilai t-hitung 3,066 dan signifikansi 0,004. (3) secara simultan promosi jabatan dan kompensasi berpengaruh signfikan terhadap kinerja karyawan, dimana diperoleh nilai F-hitung 20,738 dan signifikansi 0,000. Besarnya pengaruh promosi jabatan dan kompensasi terhadap kinerja karyawan adalah 52,9%. Saran yang dapat diberikan peneliti adalah Pizza Hut Cabang Sunset Road Point Bali diharapkan dalam meningkatkan kinerja karyawan dengan memperhatikan variabel promosi abatan dan kompensasi

This study aims to determine the effect of promotion and compensation partially and simultaneously on employee performance at Pizza Hut Sunset Road Point Bali Branch. The location of this research is Pizza Hut Sunset Road Point Bali Branch. The sample used in this study were 40 respondents. The data analysis technique used in this research is the Classical Assumption Test, Multiple Linear Regression Analysis, Coefficient of Determination Test, F Test and t Test. From the research results, it can be seen that: (1) job promotion has a significant positive effect on employee performance, where the t-count value is 3.028 and the significance is 0.004. (2) compensation has a significant positive effect on employee performance, where the t-count value is 3.066 and the significance is 0.004. (3) simultaneously promotion and compensation have a significant effect on employee performance, where the F-count value is 20,738 and the significance is 0,000. The magnitude of the effect of promotion and compensation on employee performance is 52.9%. The suggestion that researchers can give is that Pizza Hut Sunset Road Point Bali Branch is expected to improve employee performance by paying attention to the variables of promotion and compensation
Pengaruh Penerapan Corporate Social Responsibility PT. Lafarge Cement Indonesia terhadap Kesejahteraan Masyarakat di Kecamatan Lhoknga Kabupaten Aceh Besar
Authors: Jalilah  , Marwiyati  , Akmal  
Published: February 2023

Corporate Social Responsibility (CSR) merupakan bentuk tanggung jawab atau kewajiban perusahaan terhadap lingkungan. Setiap perusahaan terutama yang bergerak di bidang Sumber Daya Alam (SDA) memiliki kewajiban untuk menjalankan kegiatan Corporate Social Responsibility (CSR). PT. Lafarge Cement Indonesia (LCI) Lhoknga Aceh Besar merupakan salah satu perusahaan yang juga telah menerapkan CSR dalam beberapa bidang, seperti pendidikan, kesehatan, ekonomi dan agama. Tujuan penelitian ini adalah untuk mengetahui pengaruh pelaksanaan CSR PT Lafarge Cement Indonesia bidang pendidikan, kesehatan, ekonomi dan agama terhadap kesejahteraan masyarakat di Kecamatan Lhoknga. Penelitian ini menggunakan pendekatan kuantitatif melalui penyebaran kuesioner kepada 100 responden yang merupakan masyarakat Kecamatan Lhoknga. Hasil penelitian menunjukkan bahwa pelaksanaan program CSR PT Lafarge Cement Indonesia bidang pendidikan, kesehatan, ekonomi dan agama secara parsial atau simultan berpengaruh signifikan terhadap kesejahteraan masyarakat di Kecamatan Lhoknga Kabupaten Aceh Besar. Berdasarkan hasil uji R square menunjukkan bahwa kesejahteraan masyarakat di Kecamatan Lhoknga Kabupaten dipengaruhi oleh program CSR PT Lafarge Cement Indonesia sebesar 34,5%.
Effects of 16% Carbamide Peroxide on Optical Properties of Thermally Aged Monolithic CAD-CAM Glass Ceramics with Different Surface Treatments
Authors: Murat Sema , Batak Burcu , Yilmaz Deniz , Öztürk Caner 
Published: February 2023

SUMMARYThis study aimed to investigate the effects of 16% carbamide peroxide (CP) on the relative translucency parameter (RTP) and color stability of thermally aged CAD-CAM glass-ceramics with glazing or polishing. Three different CAD-CAM blocks—feldspathic (VM), lithium disilicate (IPS), and zirconia-reinforced lithium silicate ceramic (VS)—were used in this study. The specimens were divided into two groups (n=10) according to surface treatments (glazing or polishing). Bleaching treatment with 16% CP was applied to the thermally aged specimens. A spectrophotometer (VITA Easyshade Advance) was used to measure the CIE L*a*b*coordinates of the specimens on white and black backgrounds, and RTP and color difference (ΔE00) values were calculated. The surface topography of the specimens and the atomic weight of the elements were analyzed with scanning electron microscopy and energy-dispersive x-ray. The data were analyzed by using the two-way ANOVA test for ΔE00 values and two-way repeated measures ANOVA test for RTP and color parameters values (a=0.05) and the Tukey post-hoc test was used for multiple comparisons of the groups. RTP values were statistically influenced by material type, bleaching, and finishing technique, and the interaction among these factors was found to be significant (p&lt;0.05). ΔE00 values were statistically influenced by material type, finishing technique, and the interaction among these factors was also found to be significant (p&lt;0.05). IPS presented significantly lower RTP and ΔE00 values for both glazed and polished surfaces (p&lt;0.05). 16% CP bleaching agent caused changes in translucency of aged VM and IPS at different levels. Glazed surfaces presented higher color stability in comparison to mechanically polished surfaces for VS (p&lt;0.05).