bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiation induced dermatitis following infrared radiation (IR) therapy in a diagnosed case of systemic lupus erythematosus (SLE): a case report
Authors: Sah Sunny Kumar 
Published: March 2023

Infrared radiation is increasingly being used for cosmetic and wellness purposes. Repeated exposure to source of Infrared radiation results in a skin lesion described as erythema ab igne. Quackery is being committed by the so called therapist who uses IR radiation luring the patient for promising result. . Instead patients land up with life threatening complication like our case. Here article we present to you a 39 year old female who presented with skin lesions after she underwent radiation therapy. We have included clinical findings of the case with review of the literature.
Early diagnosis of atypical rupture of scarred uterus: A case Report from Rural Nepal
Authors: Dangal Binod , Gupta Tula Krishna , Pathak Santosh , Upreti Arun , Acharya Bibek 
Published: March 2023

A 28 years female from rural municipality of Dolakha was referred to our center diagnosis of G2P1 at 40 weeks of gestation in active stage of labor with previous CS. With the view of symptoms and history of previous CS, patient was shifted to Operation Theatre for delay in latent stage of labor, ruptured uterus identified at operating table and Caesarian Hysterectomy was done. Her post-operative hospital stay was uneventful.
Spontaneous silent rupture can occur in women without any alarming symptom. Rapid recognition of potential uterine rupture and immediate laparotomy lower the rate of perinatal death.
FDA-APPROVED MOLECULAR TESTS USED TO DEFINE HUMAN PAPILLOMAVIRUS (HPV) INFECTIONS WHICH CAUSE CERVIX CANCER
Authors: ÇALI Abdulhamit , ASLAN Rukiye , ÇELİK Cem , ALİM Ahmet 
Published: March 2023

Human papillomavirus (HPV) is a non-enveloped, commonly sexually transmitted virus with icosahedral symmetry and double-stranded circular DNA. Its genome, which is about 8 kb in size, encodes early genes (E1-8) and two late structural capsid genes (L1 and L2). Among the genes that play a role in viral pathogenesis, L1, E6, and E7 genes frequently exist. The E6 and E7 viral genes have a significant role in apoptosis inhibition, viral spread, development of squamous intraepithelial lesion (SIL), cell immortalization, neoplastic transformation, and invasive cancer.
Demonstration of the relationship between cervical cancer and HPV infections has led to increased interest in this subject and the classification of some HPV genotypes in the high-risk group (HR-HPV) for cervical cancer. Numerous commercial molecular tests have been developed for the identification of HPV genotypes involving different approaches. HPV molecular tests approved by the US Food and Drug Administration (FDA) include Hybrid Capture® 2 (HC2), Cervista™, cobas®, Aptima®, and BD Onclarity™. This article reviews the methodologies, limitations, and commonalities of five FDA-approved tests. The HC2 and Cervista™ tests use non-PCR-based signal amplification methods, while the cobas® and BD Onclarity™ tests use PCR-based target amplification methods. On the other hand, the Aptima® test uses the mRNA transcriptional mediated amplification (TMA) method.
Each of these methods used in the diagnosis and follow-up of HPV has its strengths and weaknesses. These HPV molecular tests have high sensitivity and specificity. They are also more automated and repeatable than cytological methods. In addition to these advantages, there are also several limitations. Because of these limitations, molecular tests are no more perfect than cytological tests. This situation shows that these tests should not be used alone in the evaluation of HPV infections and cancer identification. On the contrary, HPV test results should be correlated with cytology or biopsy findings.
An Evaluation of a Marginal Land’s Geological Engineering Properties in Borikiri Sandfill, Port Harcourt Nigeria
Authors: Morrison Tammy , Esonanjor Erefama Ekine 
Published: March 2023

Aim: The aim of this study was to assess the geological engineering properties of a marginal land in Borikiri Sandfill, Port Harcourt, Nigeria, using both field and laboratory investigations.
Study Design: The study design involved the drilling of 4 boreholes and standard penetration tests to determine the soil profile and index properties such as particle size analysis, atterberg limits, and moisture content. Consolidation and triaxial tests were also performed to determine the values of the coefficients of permeability (k), volume compressibility (Mv), and consolidation (Cv).
Place and Duration of Study: The Study was conducted in Borikiri Sandfill, Port Harcourt between February and May 2020.
Methods: This study's methodology included field research, laboratory analysis, and testing. Drilling and conventional penetration tests were used to assess the soil profile. Laboratory tests such as particle size analysis, atterberg limits, and moisture content were used to determine the index characteristics. The values of permeability (k), volume compressibility (Mv), and consolidation (Cv) were also determined using triaxial and consolidation tests.
Results: The results of the study showed that the soil profile consists of five stratigraphic sequences, with a top organic silty layer followed by a sandy layer, a dark plastic layer, a dark silty clayey sand, and a well-graded sand. The clays had an average Liquid limit (LL) of 45% and a Plastic Limit (PL) value of 23%. The values of k, Mv, and Cv were determined to be 2.1 x 10-7 m/s, 1.8 x 10-4–2.5 x 10-4 m2/MN, and 3.8 m2/yr, respectively. The average bearing capacity values at 2.5 m and 4.5 m depths were determined to be 186.39 kPa and 278.71 kPa, respectively. Settlement values were calculated empirically for immediate and consolidation settlement, with immediate settlement being high at 25.85 mm and consolidated settlement being 7.53mm. T50 and T90 values were also determined to be 1.32 and 4.52 years, respectively.
Conclusion: It is recommended that a shallow foundation, down to the first layer, can be used for any light construction on the marginal land in Borikiri Sandfill, Port Harcourt, Nigeria. The values of k, Mv, and Cv also indicate that the soil is relatively compressible, which should be taken into account in any design or construction activities.
Assessment of Water Quality in Ganga River Ghats of Varanasi District, Uttar Pradesh, India
Authors: Singh Y. V. , Bharteey Prem Kumar , Singh Kajal , Borah Sanjib Ranjan , Kumar Ashok , Pal Sudhir , Barla Francis Xavier 
Published: March 2023

Water is the most vital biosphere component since it sustains all life, circulates and cycles nutrients. Water is also necessary for power generation, navigation, agricultural irrigation and sewage disposal. The increasing water demand is a result of the rising population and industrialization and has severely compromised water quality. Water quality assessment is the most important process for evaluating the chemical characteristics of water bodies. To assess whether the water is suitable for a variety of uses after locating any pollutants, contaminants, or other potentially hazardous compounds that may be present in the water. A systematic study was conducted to assess the water quality in the Ganga river in the Ghats of Varanasi district of Uttar Pradesh, India, from January to March 2019. The assessment involves water samples from different Ghats along the river, namely Babua Pandey Ghat (G1), Digpatia Ghat (G2), Chausatti Ghat (G3), Ranamahal Ghat (G4), and Darbhanga Ghat (G5). The analytical data from various physico-chemical parameters indicates that the pH values were found to be near neutral, electrical conductivity (EC) did not differ significantly, Ca+Mg varied from 22.80 to 28.40 mg/L, Cl- was found to be 2.40 to 3.20 mg/L, Na+ varied from 1.0 to 1.10 mg/L, K+ and SO42- showed a similar trend, TS was varied from 400 to 1200 mg/L, DO varied from 5.80 to 7.30 mg/L, COD varied from 16.0 to 22.40 mg/L, NO3- varied from 25.27 to 29.60 mg/L, B varied from 4.90 to 5.80 mg/L, SAR is 0.27 to 0.33 mg/L, The Bureau of Indian Standard (BIS) has been considered to assess the suitability for drinking and other purposes and It concluded that some of the parameters were almost constant for all the five Ghats samples, like Na+ and K+ content, while other parameters varied. Out of thirteen parameters, only three (NO3-, B, and Cl-) showed an increasing trend.
Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels
Authors: Jenssen Marita , Furberg Anne-Sofie , Jorde Rolf , Wilsgaard Tom , Danielsen Kjersti 
Published: March 2023

ImportanceTopical vitamin D analogues are routine treatment for psoriasis, but the effect of oral supplementation has not been established.ObjectiveTo examine the effect of vitamin D supplementation on psoriasis severity throughout the winter.Design, Setting, and ParticipantsThis randomized, double-blind placebo-controlled clinical trial with 2 parallel groups was performed through 2 winter seasons (2017 to 2018 and 2018 to 2019). Randomization was computer generated. All participants, health care clinicians, and outcome assessors were masked to group assignment. Each participant was followed for 4 months. The presented analyses were conducted in May 2022. The trial was conducted at the clinical research unit of the University Hospital of North Norway (Tromsø; Norway). Adults from the general population in Tromsø with active plaque psoriasis and 25-hydroxyvitamin D (25[OH]D) levels of less than 24 ng/mL (to convert to nmol/L, multiply by 2.496) were included.InterventionVitamin D (cholecalciferol, 100 000 IU, loading dose, followed by 20 000 IU/week) or placebo for 4 months.Main outcomes and MeasuresPsoriasis Area Severity Index (PASI) (primary outcome), Physician Global Assessment, self-administered PASI, and Dermatology Life Quality Index scores (secondary outcomes).ResultsA total of 122 participants (46 women [37.7%]; mean [SD] age, 53.6 [10.0] years; mean [SD] PASI score, 3.1 [2.0]; mean [SD] serum 25(OH)D, 14.9 [3.9] ng/mL) were included. Of these, 60 (49.2%) were randomized to the vitamin D group and 62 (50.8%) to the placebo group. A total of 120 participants (59 vitamin D [49.2%]/61 placebo [51.8%]) completed the study. By completion, mean (SD) 25(OH)D levels were 29.7 (5.2) ng/mL (vitamin D) and 12.0 (3.8) ng/mL (placebo). There was no significant difference in change in PASI score between the groups (adjusted difference, 0.11; 95% CI, −0.23 to 0.45). There was no significant difference in change in Physician Global Assessment score (adjusted odds ratio, 0.66; 95% CI, 0.27-1.63), self-administered PASI (adjusted difference, −0.60; 95% CI, −1.76 to 0.55) or Dermatology Life Quality Index (adjusted difference, −0.86; 95% CI, −1.9 to 0.19) between the groups. No adverse effects of the intervention were registered.Conclusion and RelevanceThe results of this randomized clinical trial showed that vitamin D supplementation did not affect psoriasis severity. Low baseline severity scores may explain the lack of measurable effect. Levels of 25(OH)D in the intervention group increased to a less-than-expected degree based on previous experimental data from the same source population, and this may have affected the results.Trial RegistrationClinicalTrials.gov Identifier: NCT03334136
Association of Body Surface Area With Access to Deceased Donor Liver Transplant and Novel Allocation Policies
Authors: Kling Catherine E. , Biggins Scott W. , Bambha Kiran M. , Feld Lauren D. , Perkins John H. , Reyes Jorge D. , Perkins James D. 
Published: March 2023

ImportanceSmall waitlist candidates are significantly less likely than larger candidates to receive a liver transplant.ObjectiveTo investigate the magnitude of the size disparity and test potential policy solutions.Design, Setting, and ParticipantsA decision analytical model was generated to match liver transplant donors to waitlist candidates based on predefined body surface area (BSA) ratio limits (donor BSA divided by recipient BSA). Participants included adult deceased liver transplant donors and waitlist candidates in the Organ Procurement and Transplantation Network database from June 18, 2013, to March 20, 2020. Data were analyzed from January 2021 to September 2021.ExposuresCandidates were categorized into 6 groups according to BSA from smallest (group 1) to largest (group 6). Waitlist outcomes were examined. A match run was created for each donor under the current acuity circle liver allocation policy, and the proportion of candidates eligible for a liver based on BSA ratio was calculated. Novel allocation models were then tested.Main Outcomes and MeasuresTime on the waitlist, assigned Model for End-Stage Liver Disease (MELD) score, and proportion of patients undergoing a transplant were compared by BSA group. Modeling under the current allocation policies was used to determine baseline access to transplant by group. Simulation of novel allocation policies was performed to examine change in access.ResultsThere were 41 341 donors (24 842 [60.1%] male and 16 499 [39.9%] female) and 84 201 waitlist candidates (53 724 [63.8%] male and 30 477 [36.2%] female) in the study. The median age of the donors was 42 years (IQR, 28-55) and waitlist candidates, 57 years (IQR, 50-63). Females were overrepresented in the 2 smallest BSA groups (7100 [84.0%] and 7922 [61.1%] in groups 1 and 2, respectively). For each increase in group number, waitlist time decreased (234 days [IQR, 48-700] for group 1 vs 179 days [IQR, 26-503] for group 6; P &amp;lt; .001) and the proportion of the group undergoing transplant likewise improved (3890 [46%] in group 1 vs 4932 [57%] in group 6; P &amp;lt; .001). The smallest 2 groups of candidates were disadvantaged under the current acuity circle allocation model, with 37% and 7.4% fewer livers allocated relative to their proportional representation on the waitlist. Allocation of the smallest 10% of donors (by BSA) to the smallest 15% of candidates overcame this disparity, as did performing split liver transplants.Conclusions and RelevanceIn this study, liver waitlist candidates with the smallest BSAs had a disadvantage due to size. Prioritizing allocation of smaller liver donors to smaller candidates may help overcome this disparity.
The Challenges of Implementing Surface‐enhanced Raman Scattering in Studies of Biological Systems
Authors: Królikowska Agata , Witkowski Marcin , Piotrowski Piotr 
Published: March 2023

Abstract

The power of
surface‐enhanced Raman scattering
(
SERS
) in bioanalytics arises from the plasmonic amplification of vibration signals and the use of nanostructures allowing for miniaturization of the sensing platform. SERS spectroscopy also inherits intrinsic advantages of Raman scattering: vibrational fingerprint distinctive for every molecule, utilization of lasers, and confocal microscopes, which confines the detection spot, and feasibility of performing the measurements in water‐containing media; all beneficial in biosamples. In this article, the readers will find a thorough summary of the state of the art in bioSERS studies, which overviews the tremendous progress made in the field over the last few years. The challenges of implementing SERS spectroscopy into the investigation of biological systems are outlined, and miscellaneous experimental strategies required for such studies are reviewed. The selected examples of SERS‐based analysis of biosamples, ranging from the detection of simple biomolecules, followed by much more complex cell and tissue studies, and ultimately reaching SERS‐based analytical procedures for the detection of pathogens are presented. Consequently, the advances that were prerequisites in the context of upgrading SERS into a mainstream real‐life bioanalytical technique are highlighted. In the end, the future directions (see Scheme 1) that nowadays attract the greatest interest in the field are discussed, assessing an outlook for current and future biospectroscopists.
Automatic product copywriting for e‐commerce
Authors: Zou Yanyan , Zhang Xueying , Zhou Jing , Diao Shiliang , Chen Jiajia , Ding Zhuoye , He Zhen , He Xueqi , Xiao Yun , Long Bo , Ma Mian , Xu Sulong , Yu Han , Wu Lingfei 
Published: March 2023

AbstractProduct copywriting is a critical component of e‐commerce recommendation platforms. It aims to attract users' interest and improve user experience by highlighting product characteristics with textual descriptions. In this paper, we report our experience deploying the proposed Automatic Product Copywriting Generation (APCG) system into the JD.com e‐commerce product recommendation platform. It consists of two main components: (1) natural language generation, which is built from a transformer–pointer network and a pretrained sequence‐to‐sequence model based on millions of training data from our in‐house platform; and (2) copywriting quality control, which is based on both automatic evaluation and human screening. For selected domains, the models are trained and updated daily with the updated training data. In addition, the model is also used as a real‐time writing assistant tool on our live broadcast platform. The APCG system has been deployed in JD.com since February 2021. By September 2021, it has generated 2.53 million product descriptions, and improved the overall averaged click‐through rate (CTR) and the conversion rate (CVR) by 4.22 and 3.61%, compared to baselines, respectively, on a year‐on‐year basis. The accumulated gross merchandise volume (GMV) made by our system is improved by 213.42%, compared to the number in February 2021.
Paper‐Mill Waste Reinforced Nanofluidic Membrane as High‐Performance Osmotic Energy Generators
Authors: Song Guanghui , Zhan Yan , Hu Yajie , Rao Jun , Li Nan , Wu Zhongxuan , Su Zhenhua , Lü Baozhong , Liu Ruiping , Jiang Bo , Chen Gegu , Peng Feng 
Published: March 2023

AbstractNanofluidic membranes consisting of 2D materials and polymers are considered promising candidates for harvesting osmotic energy from river estuaries owing to their unique ion channels. However, micron‐scale polymer chains agglomerate in the nanochannels, resulting in steric hindrance and affection ion transport. Herein, a nanofluidic membrane is designed from MXene and xylan nanoparticles that are derived from paper‐mill waste. The demonstrated membrane reinforced by paper‐mill waste has the characteristics of green, low‐cost, and outstanding performance in mechanical properties and surface‐charge‐governed ionic transport. The MXene/carboxmethyl xylan (CMX) membrane demonstrates a high surface charge (ζ‐potential of −44.3 mV) and 12 times higher strength (284.96 MPa) than the pristine MXene membrane. The resulting membrane shows intriguing features of high surface charge, high ion selectivity, and reduced steric hindrance, enabling it high osmotic energy generation performance. A potential of the nanofluidic membrane is ≈109 mV, the corresponding current of up to 2.73 µA, and the output power density of 14.52 mW m−2 are obtained under a 1000‐fold salt concentration gradient. As the electrolyte pH increases, the power density reaches 56.54 mW m−2. This works demonstrate that CMX nanoparticles can effectively enhance the properties of the nanofluidic membrane and provide a promising strategy to design high‐performance nanofluidic devices.
Novel Movable Typing for Personalized Vein‐Chips in Large Scale: Recapitulate Patient‐Specific Virchow's Triad and its Contribution to Cerebral Venous Sinus Thrombosis
Authors: Zhao Yunduo Charles , Zhang Yingqi , Wang Zihao , Jiang Fengtao , Kyanian Kiarash , Aye San‐Seint‐Seint , Hong Tianbo , Vatankhah Parham , Nasser Arian , Sun Allan , Moldovan Laura , Su Qian P. , Cho Ann‐Na , Wang Yao , Passam Freda , Ang Timothy , Ju Lining Arnold 
Published: March 2023

AbstractThe Vein‐Chip recapitulates CVST Virchow's triad and enables systematic characterization of venous thrombogenesis with respect to fibrin formation and platelet aggregation. Distinct from the arterial setting, platelets universally adhere across the entire CVS Vein‐Chip independent of stenotic geometry and flow disturbance. Intriguingly, fibrin propagates along with the flow direction, but exclusively deposits to the inner vessel wall. Upon inflammatory endothelial injury, fibrin deposition mirrors to the outer vessel wall, but still not in the lumen. Together, the Vein‐Chip promises future applications for personalized thrombotic assessment and monitoring.
Multi‐Catcher Polymers Regulate the Nucleolin Cluster on the Cell Surface for Cancer Therapy
Authors: Cheng Feng , Jiang Yongjian , Kong Bo , Lin Huarong , Shuai Xinjia , Hu Pingping , Gao Pengfei , Zhan Lei , Huang Chengzhi , Li Chunmei 
Published: March 2023

AbstractCell signal transduction mediated by cell surface ligand‐receptor is crucial for regulating cell behavior. The oligomerization or hetero‐aggregation of the membrane receptor driven by the ligand realizes the rearrangement of apoptotic signals, providing a new ideal tool for tumor therapy. However, the construction of a stable model of cytomembrane receptor aggregation and the development of a universal anti‐tumor therapy model on the cellular surface remain challenging. This work describes the construction of a “multi‐catcher” flexible structure GC‐chol‐apt‐cDNA with a suitable integration of the oligonucleotide aptamer (apt) and cholesterol (chol) on a polymer skeleton glycol chitosan (GC), for the regulation of the nucleolin cluster through strong polyvalent binding and hydrophobic membrane anchoring on the cell surface. This oligonucleotide aptamer shows nearly 100‐fold higher affinity than that of the monovalent aptamer and achieves stable anchoring to the plasma membrane for up to 6 h. Moreover, it exerts a high tumor inhibition both in vitro and in vivo by activating endogenous mitochondrial apoptosis pathway through the cluster of nucleolins on the cell membrane. This multi‐catcher nano‐platform combines the spatial location regulation of cytomembrane receptors with the intracellular apoptotic signaling cascade and represents a promising strategy for antitumor therapy.
Broadband Emission Origin in Metal Halide Perovskites: Are Self‐Trapped Excitons or Ions?
Authors: Jiang Feng , Wu Zhennan , Lu Min , Gao Yanbo , Li Xin , Bai Xue , Ji Yuan , Zhang Yu 
Published: March 2023

AbstractIt has always been a goal to realize high efficiency and broadband emission in single‐component materials. The appearance of metal halide perovskites makes it possible. Their soft lattice characteristics and significant electron–phonon coupling synergistically generate self‐trapped excitons (STEs), contributing to a broadband emission with a large Stokes shift. Meanwhile, their structural/compositional diversity provides suitable active sites and coordination environments for doping of ns2 ions, allowing 3Pn(n=0,1,2)→1S0 transitions toward broadband emission. The ns2 ions emission is phenomenologically similar to that of STE emission, hindering in‐depth understanding of their emission origin, and leading to failure to meet the design requirements for practical applications. In this scenario, herein, the fundamentals and development of such two emission mechanisms are summarized to establish a clear and comprehensive understanding of the broadband emission phenomenon, which may pave the way to an ideal customization of broadband‐emission metal halide perovskites.