bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Mn content on austenite stability and mechanical properties of low Ni alumina-forming austenitic heat-resistant steel: a first-principles study
Authors: Zhao Yanjun , Cao Yunfei , Wen Weiying , Lu Zepeng , Zhang Jingrui , Liu Yafei , Chen Peilin 
Published: April 2023

AbstractLow Ni alumina-forming austenitic (AFA) heat-resistant steel is an advanced high-temperature stainless steel with reduced cost, good machinability, high-temperature creep strength, and high-temperature corrosion resistance. Using the First-principles approach, this study examined the effect of Mn content on austenite stability and mechanical properties at the atomic level. Adding Mn to low Ni-AFA steel increases the unit cell volume with an accompanying increase in the absolute value of formation energy; the austenite formed more easily. The austenitic matrix binding energy decreases and remains negative, indicating austenite stability. As the Mn content increases from 3.2 to 12.8 wt%, the system's bulk modulus (B) rises significantly, and the shear modulus (G) falls. In addition, the system's strength and hardness decrease, and the Poisson ratio of the austenite matrix increases with improved elasticity; the system has excellent plasticity with an increase in the B/G. For the Fe22–Cr5–Ni3–Al2 system, with the increase of Mn content, the electron density distribution between the atoms is relatively uniform, and the electrons around the Mn atoms are slightly sparse, which will slightly reduce the structural stability of the matrix. The experiment demonstrated the matrix maintains the austenitic structure when adding 3.2–12.8 wt% Mn elements to low Ni-AFA steel. At an Mn content of 8 wt%, the overall mechanical properties of the high-Mn AFA steel are optimal, with a tensile strength of 581.64 MPa, a hardness of 186.17 HV, and an elongation of 39%.
Integrative analyses of ferroptosis and immune related biomarkers and the osteosarcoma associated mechanisms
Authors: Li Guibin , Lei Jie , Xu Dexin , Yu Wenchang , Bai Jinping , Wu Ge 
Published: April 2023

AbstractOsteosarcoma (OS) is the most common primary malignant bone tumor with high metastatic potential and relapse risk. To study the regulatory mechanism of the OS microenvironment, a complex regulatory network involving the ferroptosis- and immune response-related genes remains to be established. In the present study, we determined the effect of a comprehensive evaluation system established on the basis of ferroptosis- and immune-related genes on the immune status, related biomarkers, prognosis, and the potential regulatory networks underlying OS based on the TARGET and Gene Expression Omnibus databases that contain information on OS patients by bioinformatics analyses. We first characterized individual ferroptosis scores and immune scores through gene set variation analysis (GSVA) against TARGET-OS datasets. We then identified differentially expressed genes by score groups. Weighted gene co-expression network analysis was performed to identify the most relevant ferroptosis-related and immune-related gene modules, which facilitated the identification of 327 ferroptosis gene and 306 immune gene candidates. A 4-gene (WAS, CORT, WNT16, and GLB1L2) signature was constructed and valuation using the least absolute shrinkage and selection operator-Cox regression models to effectively predict OS prognosis. The prediction efficiency was further validated by GSE39055. We stratified patients based on the prognostic scoring systems. Eight hub genes (namely CD3D, CD8A, CD3E, IL2, CD2, MYH6, MYH7, and MYL2) were identified, and TF–miRNA target regulatory networks were constructed. Furthermore, Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, gene set enrichment analysis, and GSVA were used to determine the signature’s potential pathways and biological functions, which showed that the hub genes were enriched in ferroptosis-associated biological functions and immune-associated molecular mechanisms. Thereafter, we investigated the proportion and infiltration extent of 22 infiltrating immune cells by using CIBERSORT, which revealed significant subgroup differences in CD8 + T cells, M0 macrophages, and M2 macrophages. In conclusion, we determined a new ferroptosis-related and immune-related gene signature for predicting OS patients’ prognosis and further explored the ferroptosis and immunity interactions during OS development, which provides insights into the exploration of molecular mechanisms and targeted therapies in patients with OS.
Sb2Te3 nanoparticle-containing single-walled carbon nanotube films coated with Sb2Te3 electrodeposited layers for thermoelectric applications
Authors: Eguchi Rikuo , Hoshino Koki , Takashiri Masayuki 
Published: April 2023

AbstractSingle-walled carbon nanotubes (SWCNTs) are promising thermoelectric materials owing to their flexibility and excellent durability when exposed to heat and chemicals. Thus, they are expected to be used in power supplies for various sensors. However, their thermoelectric performances are inferior to those of inorganic thermoelectric materials. To improve the thermoelectric performance while maintaining the excellent characteristics of SWCNTs, a novel approach to form inorganic thermoelectric layers on the SWCNT bundle surfaces using electrodeposition is proposed. We synthesized Sb2Te3 nanoparticle-containing SWCNT films and coated them with electrodeposited Sb2Te3 layers. The Sb2Te3 nanoparticles were synthesized via a spontaneous redox reaction, which were then added to a SWCNT dispersion solution, and films were produced via vacuum filtration. At higher nanoparticle contents in the films, the Sb2Te3 electrodeposited layers completely covered the SWCNT bundles owing to the increase in the concentration of precursor ions near the SWCNT bundle surface, which in turn was the result of melted nanoparticles. The thermoelectric performance improved, and the maximum power factor at approximately 25 °C was 59.5 µW/(m K2), which was 4.7 times higher than that of the normal SWCNT film. These findings provide valuable insights for designing and fabricating high-performance flexible thermoelectric materials.
A fabric-based wearable sensor for continuous monitoring of decubitus ulcer of subjects lying on a bed
Authors: Lee Soyeon , Kim Seung-Rok , Jeon Kun-Hoo , Jeon Jun-Woo , Lee Ey-In , Jeon Jiwan , Oh Je-Heon , Yoo Ju-Hyun , Kil Hye-Jun , Park Jin-Woo 
Published: April 2023

AbstractFor multifunctional wearable sensing systems, problems related to wireless and continuous communication and soft, noninvasive, and disposable functionality issues should be solved for precise physiological signal detection. To measure the critical transitions of pressure, temperature, and skin impedance when continuous pressure is applied on skin and tissue, we developed a sensor for decubitus ulcers using conventional analog circuitry for wireless and continuous communication in a disposable, breathable fabric-based multifunctional sensing system capable of conformal contact. By integrating the designed wireless communication module into a multifunctional sensor, we obtained sensing data that were sent sequentially and continuously to a customized mobile phone app. With a small-sized and lightweight module, our sensing system operated over 24 h with a coin-cell battery consuming minimum energy for intermittent sensing and transmission. We conducted a pilot test on healthy subjects to evaluate the adequate wireless operation of the multifunctional sensing system when applied to the body. By solving the aforementioned practical problems, including those related to wireless and continuous communication and soft, noninvasive, and disposable functionality issues, our fabric-based multifunctional decubitus ulcer sensor successfully measured applied pressure, skin temperature, and electrical skin impedance.
The Apple Watch spO2 sensor and outliers in healthy users
Authors: Schröder Christina , Förster Robert , Zwahlen Daniel R. , Windisch Paul 
Published: April 2023

AbstractIt is unclear how frequently the Apple Watch produces spO2 measurements outside of the normal range in healthy individuals at rest. We conducted a head-to-head comparison in 38 healthy individuals between two watches and two medical-grade pulse oximeters. Fourteen percent of watch measurements yielded spO2 values below 95%, with no values below 92%. Results suggest that outliers measured by the watch should not be a cause for concern in otherwise healthy individuals.
A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation
Authors: Sato Waka , Watanabe-Takahashi Miho , Murata Takuya , Utsunomiya-Tate Naoko , Motoyama Jun , Anzai Masataka , Ishihara Seiko , Nishioka Nanako , Uchiyama Hina , Togashi Juri , Nishihara Saeka , Kawasaki Kiyoshi , Saito Takashi , Saido Takaomi C. , Funamoto Satoru , Nishikawa Kiyotaka 
Published: April 2023

AbstractInhibition of amyloid-β peptide (Aβ) accumulation in the brain is a promising approach for treatment of Alzheimer’s disease (AD). Aβ is produced by β-secretase and γ-secretase in endosomes via sequential proteolysis of amyloid precursor protein (APP). Aβ and APP have a common feature to readily cluster to form multimers. Here, using multivalent peptide library screens, we identified a tetravalent peptide, LME-tet, which binds APP and Aβ via multivalent interactions. In cells, LME-tet-bound APP in the plasma membrane is transported to endosomes, blocking Aβ production through specific inhibition of β-cleavage, but not γ-cleavage. LME-tet further suppresses Aβ aggregation by blocking formation of the β-sheet conformation. Inhibitory effects are not observed with a monomeric peptide, emphasizing the significance of multivalent interactions for mediating these activities. Critically, LME-tet efficiently reduces Aβ levels in the brain of AD model mice, suggesting it may hold promise for treatment of AD.
Two distinct types of turbidity currents observed in the Manila Trench, South China Sea
Authors: Liu Meng , Wang Zhiwen , Yu Kaiqi , Xu Jingping 
Published: April 2023

AbstractSediment gravity flows are the most direct and efficient transport mechanisms for moving terrestrial sediments into deep oceans. Scarcity of firsthand measurements, however, has hindered the quantitative, even qualitative characterization of such flows. Here we present a unique year-long data record from ~4000 m depth in the Manila Trench that captured two very different gravity flows in terms of their hydraulic and sedimentary properties. The first flow was of slow speed (~40 cm s−1) and long duration (~150 h), thus nicknamed ‘Tortoises’, and carried very fine sediment with low concentration (~0.01%). The fast (~150 cm s−1) but short-lived (~40 h) flow, nicknamed ‘Hares’, carried much coarser sediment with higher concentration (~1.2%). Clay mineral compositions suggest that the ‘Tortoises’ originated from upstream canyon wall slumping, whereas the ‘Hares’ was likely submarine canyons southwest of Taiwan Island due to typhoon. Grain size is a key factor in determining evolution of turbidity currents.
Cobalt(iii)–salen decorated stereoregular optically active helical polyisocyanides enable highly effective cooperative asymmetric catalysis toward the kinetic resolution of epoxides
Authors: Kang Shu-Ming , Song Xue , Zhang Ting-Ting , Xu Lei , Zhu Yuan-Yuan , Wu Zong-Quan 
Published: April 2023

The decoration of Co(iii)–salen onto stereoregular optically active helical polyisocyanides considerably increased efficiency and enantioselectivity of kinetic resolution of epoxides through improved cooperative asymmetric catalysis mode.
Impact of Molecular Status on Metastasectomy of Colorectal Cancer Liver Metastases
Authors: Wang Yan-Yan , Xin Ze-Chang , Wang Kun 
Published: April 2023

AbstractAlthough surgical resection could provide better survival for patients with colorectal cancer liver metastases (CRLM), the recurrence rate after resection of CRLM remains high. The progress of genome sequencing technologies has greatly improved the molecular understanding of colorectal cancer. In the era of genomics and targeted therapy, genetic mutation analysis is of great significance to guide systemic treatment and identify patients who can benefit from resection of CRLM. RAS and BRAF mutations and microsatellite instability/deficient deoxyribonucleic acid (DNA) mismatch repair status have been incorporated into current clinical practice. Other promising molecular biomarkers such as coexisting gene mutations and circulating tumor DNA are under active investigation. This study aimed to review the prognostic significance of molecular biomarkers in patients with CRLM undergoing metastasectomy based on the current evidence.
Experience with “Select Crowd Review” in Peer Review for The
Thoracic and Cardiovascular Surgeon: 1-Year Experience
Authors: Gottardi Roman , Henning Peter Thomas , Bogensberger Jessica , Heinemann Markus K. 
Published: April 2023

Abstract
Objective To evaluate the experience with a new peer review method, “Select Crowd Review” (SCR): anonymized PDFs of manuscripts are accessible to a reviewer crowd via an online platform. It has access for 10 days to enter anonymized comments directly into the manuscript. A SCR-Editor summarizes the annotations, giving a recommendation. Both reviewed PDF and summary are sent back to authors. Upon submission, authors are given a choice to accept or decline SCR.
Design All manuscript submissions since introduction in July 2021 until July 2022 were analyzed regarding acceptance and quality. Manuscripts were sent to a crowd of 45 reviewers and regular double-blinded peer review at the same time. Efficiency and performance of the crowd's reviews were compared with those of regular review. For thoracic manuscripts, a crowd was not yet available.
Results SCR was accepted by the authors for 73/179 manuscripts (40.8%). After desk rejections, 51 cardiac manuscripts entered SCR. For five manuscripts, the crowd did not respond. In all remaining papers, the crowd's recommendation concurred with that of the normal reviewers. Regular peer review took up to 6 weeks. Twelve manuscripts underwent repeated SCR after revision. A median of 2 (0–9) crowd members sent in reviews. In revisions, average response was one reviewer responding.
Conclusion SCR encountered good acceptance by authors. As the first experience showed concordant recommendations compared with traditional review, we have extended SCR to thoracic manuscripts for more experience. SCR may become the sole review method for eligible manuscripts. Efficiency should be increased, especially for re-review of revisions.
Prosthesis–Patient Mismatch after Aortic Valve Replacement with the Mosaic Ultra Bioprosthesis
Authors: Dzemali Omer , Haeussler Achim , Ntinopoulos Vasileios , Biefer Hector Rodriguez Cetina , Dushaj Stak , Rings Laura , Fleckenstein Philine 
Published: April 2023

Abstract
Background Several studies have reported high rates of prosthesis–patient mismatch (PPM) after aortic valve replacement (AVR) with the Mosaic prosthesis. This work assesses the incidence of PPM after AVR with a modified version of the Mosaic prosthesis, the Mosaic Ultra.
Methods We performed a retrospective analysis of the data of 532 patients who underwent AVR with implantation of the Mosaic Ultra prosthesis in the period 2007–2016 in our institution. Patients were classified according to their indexed effective orifice area (EOAi) to severe (EOAi < 0.65 cm2/m2), moderate (EOAi 0.65–0.85 cm2/m2), and absent/mild PPM (EOAi > 0.85 cm2/m2). In-hospital postoperative outcomes and the impact of PPM on mean transvalvular pressure gradient after stratification by prosthesis size were assessed.
Results Overall, 3 (0.6%) patients had severe, 92 (17.3%) moderate, and 437 (82.1%) absent/mild PPM. There was a significant difference in PPM proportions (moderate/severe vs absent/mild PPM) across different prosthesis sizes overall (p < 0.0001), observing gradually increasing rates of PPM with decreasing prosthesis sizes. Patients with moderate/severe PPM had higher mean transvalvular pressure gradients (19 [13–25] vs 13 [10–17] mm Hg, p < 0.0001) than patients with absent/mild PPM. There was a significant difference in mean transvalvular pressure gradient between the different aortic valve prosthesis sizes overall (p < 0.0001), observing gradually increasing gradients with decreasing prosthesis sizes.
Conclusion Patients undergoing AVR with the smaller sized (19, 21, and 23 mm) Mosaic Ultra aortic valve prostheses exhibit a higher risk for moderate/severe PPM and higher mean aortic transvalvular pressure gradients than patients receiving the larger sized (25, 27, and 29 mm) prostheses.
Improving the entrepreneurial ability of rural migrant workers returning home in China: Study based on 5,675 questionnaires
Authors: Lu Yan , Zhou Yuqi , Liu Pengling 
Published: April 2023

AbstractInnovation and entrepreneurship play a key role in the development of a country’s economy and society. In recent years, along with the comprehensive implementation of China’s rural revitalization strategy, the government has issued many policies to support and benefit farmers, and the investment environment in villages has been greatly improved, attracting more and more migrant workers to return to their hometowns to start businesses. Improving the entrepreneurial ability of China’s returning migrant workers is very important. A review of the previous literature showed that both internal personal factors and external environmental factors can affect the entrepreneurial ability of entrepreneurs. Combining the results of the questionnaire survey, this paper incorporates eight internal personal factors and eight external environmental factors into the index system for assessing entrepreneurial ability and uses a combination of SWOT analysis and AHP analysis to prioritize the factors influencing the entrepreneurial ability of returning migrant workers in China. The results are as follows: (1) The factors influencing the entrepreneurial ability of returnee entrepreneurs could be divided into two types: the individual factors of returnee entrepreneurs, and the external environmental factors. (2) Among the internal factors, technical experience and business management ability are the two main factors influencing entrepreneurial activity. (3) Among the external environmental factors, the opportunity for industrial structure adjustment and low technical content would have a higher influence on the entrepreneurial activity of returnee entrepreneurs. Accordingly, this study proposes some policy recommendations on how to improve the entrepreneurial ability of returnee entrepreneurs. Finally, the research methodology of this paper can be used as a reference for other scholars, and the research results can also be used for administrators to develop relevant policies to better improve the entrepreneurial ability of returnee entrepreneurs.
‘Gregor, are you Unstable? Check your Bandwidth…’: Adapting Kafka for Zoom in Hijinx Theatre’s Metamorphosis
Authors: Broadribb Benjamin 
Published: April 2023

Abstract
First performed live via Zoom in August 2020, Hijinx Theatre’s Metamorphosis was overtly tied to the cultural moment of the COVID-19 pandemic, offering a sense of shifting between perspectives on reality in its adaptation of Franz Kafka’s 1915 novella. The production itself appeared to be in a continual state of transformation: it shifted between scenes adapted from the novella, ‘behind-the-scenes’ vignettes in which the cast played fictionalised versions of themselves, and interactive interludes hosted by a compère-like character known as ‘the barman’. This article explores the effect of adapting Kafka’s story for the world of 2020 not only through the innovative ways in which Hijinx engaged with Zoom performance through their production at a time when experimentation with the platform as a theatrical space/medium was still very much in its infancy; but also through the manner in which the company adapted Kafka’s novella to reflect the cultural moment of the early months of lockdown. In doing so, this article considers the ways in which Hijinx’s Metamorphosis mercurially embodied both the hopelessness of life at the height of lockdown, and the optimism of being able to emerge from the tragedy and loss of the pandemic into a world with renewed hope.
Transmedia Adaptation and Transmedia Practices in the Long Nineteenth Century
Authors: Primorac Antonija 
Published: April 2023

Abstract
This review essay examines new trends in transmedia studies and their relationship to adaptation studies by focusing on two recent publications: Lissette Lopez Szwydky’s monograph Transmedia Adaptation in the Nineteenth Century (The Ohio State UP: Ohio, 2020) and the collection of essays entitled Transmedia Practices in the Long Nineteenth Century (Routledge: London, 2022) edited by Christina Meyer and Monika Pietrzak-Franger. The essay analyses the recent shift in focus in transmedia research from storytelling to practices. This shift is part of the trend to historicize the development of convergence media and draw parallels between transmedia practices in the long nineteenth century and those at work today. The essay concludes by investigating the role that adaptation and adaptation studies play in these two volumes’ explorations of nineteenth-century transmedia.
Comparative Analysis of Three Workload Measurement Methodologies in Surgical Pathology: Conclusions and Implications on Public Health Care and Costing of Pathology Services
Authors: Pantelakos Stavros , Agrogiannis Georgios 
Published: April 2023

Abstract

Objectives
To carry out a comparative analysis between 3 different workload measurement systems in surgical pathology: the Resource-Based Relative Value Scale (RBRVS), the Level 4 Equivalent (L4E), and the Automatable Activity-Based Approach to Complexity Unit Scoring (AABACUS). The RBRVS is one of the most widely used systems in terms of attempting to measure workload, whereas it has been proposed as a means of costing (and thus setting reimbursement rates) of surgical pathology services in Greece, despite being widely criticized for its inaccurate design.

Methods
Surgical pathology workload for 1 representative month at Evaggelismos General Hospital was assessed using both the RBRVS and the 2 newer methods.

Results
Pearson correlation showed a high level of correlation (0.902, P &lt; .01) between the L4E and AABACUS but less so between either of those and the RBRVS (0.712 and 0.626, respectively; P &lt; .01). The highest level of discrepancy was observed in the subspecialties of genitourinary, breast, dermatopathology, and gastrointestinal pathology. In addition, total and average working hours as calculated by the RBRVS were significantly lower compared with the other 2 systems.

Conclusions
The RBRVS tends to underestimate actual workload as a result of its inability to take specific workload parameters into account, such as slide count or the need for intradepartmental consultation.