bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technological Uncertainty, Value Appropriation, and Dense Versus Dispersed Patent Portfolios
Authors: Heeley Michael B. , Covin Jeffrey G. , Matusik Sharon F. 
Published: August 2023

AbstractPatented inventions play an important role in generating firm value, with conventional wisdom generally suggesting that dense patent portfolios promote greater value. We challenge the universality of this assumption and argue that the relationship between patent portfolio density and firm value depends on factors reflecting other key invention‐related conditions and choices. Specifically, we hypothesize that dispersed patent portfolios are positively associated with firm value when technology inputs are young and the technology is far from the locus of inventive activity, and dense portfolios are positively associated with firm value under the opposite conditions. We examine these relationships using a stock return response model, finding support for our hypotheses based on data collected from firms patenting in the chemicals technology area.
Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7‐mediated degradation of TGFβRI
Authors: Xu Xianjun , Guo Yuecheng , Luo Xin , Shen Zhenyang , Sun Zhongshang , Shen Bo , Zhou Cui , Wang Junjun , Lu Jingyi , Zhang Qingqing , Ye Yanping , Luo Ying , Qu Ying , Cai Xiaobo , Dong Hui , Lu Lungen 
Published: August 2023

AbstractBackground and PurposeLiver fibrosis is a wound‐healing reaction that eventually leads to cirrhosis. Hydronidone is a new pyridine derivative with the potential to treat liver fibrosis. In this study, we explored the antifibrotic effects of hydronidone and its potential mode of action.MethodsThe anti‐hepatic fibrosis effects of hydronidone were studied in carbon tetrachloride (CCl4)‐ and 3,5‐diethoxycarbonyl‐1,4‐dihydrocollidine (DDC)‐ induced animal liver fibrosis. The antifibrotic mechanisms of hydronidone were investigated in hepatic stellate cells (HSCs). The antifibrotic effect of hydronidone was further tested after Smad7 knockdown in HSCs in mouse models of fibrosis.ResultsIn animal models, hydronidone attenuated liver damage and collagen accumulation, and reduced the expression of fibrosis‐related genes. Hydronidone decreased the expression of fibrotic genes in HSCs. Impressively, hydronidone significantly upregulated Smad7 expression and promoted the degradation of transforming growth factor β receptor I (TGFβRI) in HSCs and thus inhibited the TGFβ‐Smad signalling pathway. Specific knockdown of Smad7 in HSCs in vivo blocked the antifibrotic effect of hydronidone.ConclusionHydronidone ameliorates liver fibrosis by inhibiting HSCs activation via Smad7‐mediated TGFβRI degradation. Hydronidone is a potential drug candidate for the treatment of liver fibrosis.
Leaf relative water content at 50% stomatal conductance measured by noninvasive NMR is linked to climate of origin in nine species of eucalypt
Authors: Coleman David , Windt Carel W. , Buckley Thomas N. , Merchant Andrew 
Published: August 2023

AbstractStomata are the gatekeepers of plant water use and must quickly respond to changes in plant water status to ensure plant survival under fluctuating environmental conditions. The mechanism for their closure is highly sensitive to disturbances in leaf water status, which makes isolating their response to declining water content difficult to characterise and to compare responses among species. Using a small‐scale non‐destructive nuclear magnetic resonance spectrometer as a leaf water content sensor, we measure the stomatal response to rapid induction of water deficit in the leaves of nine species of eucalypt from contrasting climates. We found a strong linear correlation between relative water content at 50% stomatal conductance (RWCgs50) and mean annual temperature at the climate of origin of each species. We also show evidence for stomata to maintain control over water loss well below turgor loss point in species adapted to warmer climates and secondary increases in stomatal conductance despite declining water content. We propose that RWCgs50 is a promising trait to guide future investigations comparing stomatal responses to water deficit. It may provide a useful phenotyping trait to delineate tolerance and adaption to hot temperatures and high leaf‐to‐air vapour pressure deficits.
TaSINA2B, interacting with TaSINA1D, positively regulates drought tolerance and root growth in wheat (Triticum aestivum L.)
Authors: Ma Jianhui , Wang Yudie , Tang Xiaoxiao , Zhao Dongyang , Zhang Daijing , Li Chunxi , Li Wei , Li Tian , Jiang Lina 
Published: August 2023

AbstractWheat (Triticum aestivum L.) is an important food crop mainly grown in arid and semiarid regions worldwide, whose productivity is severely limited by drought stress. Although various E3 ubiquitin (Ub) ligases regulate drought stress, only a few SINA‐type E3 Ub ligases are known to participate in such responses. Herein, we identified and cloned 15 TaSINAs from wheat. The transcription level of TaSINA2B was highly induced by drought, osmotic and abscisic acid treatments. Two‐type promoters of TaSINA2B were found in 192 wheat accessions; furthermore wheat accessions with promoter TaSINA2BII showed a considerably higher level of drought tolerance and gene expression levels than those characterizing accessions with promoter TaSINA2BI that was mainly caused by a 64 bp insertion in its promoter. Enhanced drought tolerance of TaSINA2B‐overexpressing (OE) transgenic wheat lines was found to be associated with root growth promotion. Further, an interaction between TaSINA2B and TaSINA1D was detected through yeast two‐hybrid and bimolecular fluorescence complementation assays. And TaSINA1D‐OE transgenic wheat lines showed similar drought tolerance and root growth phenotype to those observed when TaSINA2B was overexpressed. Therefore, the variation of TaSINA2B promoter contributed to the drought stress regulation, while TaSINA2B, interacting with TaSINA1D, positively regulated drought tolerance by promoting root growth.
Intracellular and mitochondrial proteomic analysis reveals antifungal mechanisms of borate on mango black spot pathogen Alternaria alternata
Authors: Chen Tingting , He Shuting , Li Shuhui , Xiao Hongmei , Song Haichao , Meng Lanhuan , Shi Xuequn 
Published: August 2023

AbstractBoron, in the form of potassium tetraborate, has previously been found to be effective at inhibiting mango black spot disease, caused by Alternaria alternata. However, the mechanisms involved in this inhibition are largely unknown. In this study, A. alternata was treated in vitro with potassium tetraborate at a concentration of 5–10 mM for 48 or 72 h. The intracellular and mitochondrial proteins were extracted from mycelium and separated using two‐dimensional electrophoresis (2‐DE). Differentially expressed proteins (DEPs) were identified using bioinformatics tools and differences between protein spots were derived from mass spectrometry (MS). Using matrix‐assisted laser desorption ionization time‐of‐flight tandem mass spectrometry (MALDI‐ToF‐MS/MS), 96 intracellular and 56 mitochondrial DEPs were identified. The intracellular proteins identified were found to be involved in posttranslational modifications, protein turnover and chaperones, while the mitochondrial proteins were involved in electron transport chains. Our results demonstrate that various metabolic pathways are involved in the antifungal activity of boron. The differential expression of 20 genes was also verified at the mRNA level by reverse transcription‐quantitative PCR. Our study suggests that borate could be used as a potential substitute for synthetic fungicides to control this postharvest disease of mango fruits.
Local government managers are on the frontlines of climate change: Are they ready?
Authors: Deslatte Aaron , Siciliano Michael D. , Krause Rachel M. 
Published: August 2023

AbstractState and local governments in the United States are the implementation agents for a vast swath of federal policies. As the country embarks on an unprecedented foray into fiscal federalism to combat climate change, we face a stark reality: many local governments are not ready. Drawing from recent data and evidence on local sustainability activities, we argue policy makers and managers at all levels of governance need to apply the lessons learned over the last two decades of subnational climate efforts. For local government managers working in the 21st century, climate change will likely be a defining social dilemma of their lifetimes. After years of inaction, the United States has taken a major step in trying to meet its greenhouse‐gas mitigation pledges. But implementation requires understanding both the opportunities and opportunity costs posed by such generational investments.
Managing my shame: Investigating the effects of organizational identity threat and public service motivation on exemplification
Authors: Molines Mathieu , Perrier Anthony 
Published: August 2023

AbstractHow do public employees respond to organizational identity threats? The present study investigates how public employees make sense of and react to threatening events that may call into question organization's core attributes and status. Using social identity theory and the appraisal theory of emotions, we develop a model in which organizational identity induced by negative media coverage threat provokes shame that results in exemplification. We further explain the role of public service motivation as a moderator of the proposed mediated relationships. Predictions are tested in an experimental study and a field study involving French police officers. Our results show that shame mediated the positive effect of organizational identity threat on police officers' exemplification behaviors. When public service motivation is high, police officers are more likely to engage in exemplification to cope with organizational identity threat than when it is slow. Theoretical and practical implications and future research directions are discussed.
Contralateral versus ipsilateral protective effect against muscle damage of the elbow flexors and knee extensors induced by maximal eccentric exercise
Authors: Chen Trevor C. , Chen Hsin‐Lian , Tseng Wei‐Chin , Chou Tai‐Ying , Tu Jui‐Hung , Parcell Allen C. , Nosaka Kazunori 
Published: August 2023

AbstractThe present study compared the ipsilateral repeated bout effect (IL‐RBE) and contralateral repeated bout effect (CL‐RBE) of the elbow flexors (EF) and knee flexors (KF) for the same interval between bouts to shed light on their mechanisms. Fifty‐two healthy sedentary young (20–28 years) men were randomly assigned to the IL‐EF, IL‐KF, CL‐EF, and CL‐KF groups (n = 13/group). Thirty maximal eccentric contractions of the EF were performed in IL‐EF and CL‐EF, and 60 maximal eccentric contractions of the KF were performed in IL‐KF and CL‐KF, with a 2‐week interval between bouts. Changes in muscle damage markers such as maximal voluntary contraction (MVC) torque, muscle soreness, and plasma creatine kinase activity, and proprioception measures before to 5 days post‐exercise were compared between groups. Changes in all variables were greater (p < 0.05) after the first than second bout for all groups, and the changes were greater (p < 0.05) for the EF than KF. The changes in all variables after the second bout were greater (p < 0.05) for the CL than IL condition for both EF and KF. The magnitude of the average protective effect was similar between CL‐EF (33%) and CL‐KF (32%), but slightly greater (p < 0.05) for IL‐EF (67%) than IL‐KF (61%). These demonstrate that the magnitude of CL‐RBE relative to IL‐RBE was similar between the EF and KF (approximately 50%), regardless of the greater muscle damage for the EF than KF. It appears that the CL‐RBE is more associated with neural adaptations at cerebrum, cerebellum, interhemispheric inhibition, and coricospinal tract, but the IL‐RBE is induced by additional adaptations at muscles.
Accuracy of antigen tests for meningococcal meningitis in cerebrospinal fluid: A diagnostic meta‐analysis
Authors: Lin Hsiu‐Ling , Chen Hui‐Mei , Lin Chih‐Yen , Chen Cheng‐Chieh 
Published: August 2023

AbstractObjectivesNeisseria meningitidis is one of the major pathogens of meningitis in children worldwide and causes invasive meningococcal disease (IMD), which is a critical illness that mainly presents as meningitis and/or septicemia in children. Identification of N. meningitidis in cerebrospinal fluid (CSF) is the gold standard for the diagnosis of meningococcal meningitis, but antigen tests have advantages such as timely results, relatively low cost, and convenience. Yet, the diagnostic accuracy of antigen tests remains uncertain. Therefore, the aim of this meta‐analysis was to evaluate the diagnostic accuracy of antigen tests for N. meningitidis in CSF.MethodsWe searched the PubMed, Embase, and Cochrane Library databases for studies evaluating the diagnostic accuracy of antigen tests for N. meningitidis in CSF. We included studies that provided sufficient data to construct a 2 × 2 table on a per‐sample basis. To determine the overall sensitivity and specificity of the antigen tests, we used polymerase chain reaction (PCR) as the reference standard and employed the hierarchical summary receiver operating characteristic model.ResultsNine studies with 4533 CSF samples were included. The meta‐analysis yielded a pooled sensitivity of 91.2% (95% confidence interval [CI]: 80.0%–100.0%) and a pooled specificity of 93.8% (95% CI: 83.9%–100.0%). A subgroup analysis of 2 studies that reported the outcomes of MeningoSpeed yielded a pooled sensitivity of 93.4% (95% CI: 90.0%–95.8%) and a pooled specificity of 91.9% (95% CI: 88.6%–94.4%). Antigen testing for the N. meningitidis serogroup X had a pooled sensitivity of 92.4% (95% CI: 85.2%–96.2%) and a pooled specificity of 99.2% (95% CI: 78.7%–100.0%).ConclusionsThe studied antigen tests had high sensitivity and specificity for the diagnosis of meningococcal meningitis in CSF specimens. Antigen testing could serve as an accurate diagnostic method for assessing patients who have a suspected N. meningitidis infection.
Platelet extracellular vesicles and their mitochondrial content improve the mitochondrial bioenergetics of cellular immune recipients
Authors: Pelletier Martin , Breton Yann , Allaeys Isabelle , Becker Yann , Benson Tom , Boilard Eric 
Published: August 2023

AbstractBackgroundMitochondria play a critical role in the production of cell energy and the regulation of cell death. Therefore, mitochondria orchestrate numerous cell effector functions, including fine‐tuning the immune system. While mitochondria are mainly found intracellularly, they can escape the confine of the cell during the process of extracellular vesicle release. Platelets patrol blood vessels to ensure vasculature integrity and to support the immune system. In blood, platelets are the primary source of circulating mitochondria. Activated platelets produce extracellular vesicles, including a subset of mitochondria‐containing vesicles.Study Design and MethodsWe characterized mitochondrial functions in platelet‐derived extracellular vesicles, and examined whether they could impact the bioenergetics of cellular immune recipients using an extracellular flux analyzer to measure real‐time bioenergetics.ResultsWe validated that extracellular vesicles derived from activated platelets contain the necessary mitochondrial machinery to respirate and generate energy. Moreover, neutrophils and monocytes efficiently captured platelet‐derived extracellular vesicles, enhancing their mitochondrial fitness. This process required functional mitochondria from donor platelets, as it was abolished by the inactivation of extracellular mitochondria using mitochondrial poison.DiscussionTogether, the data suggest that extracellular mitochondria produced by platelets may support other metabolic functions through transcellular bioenergetics.
Effects of nutritional counseling on physical performance and muscle strength in older adults: a systematic review protocol
Authors: Buckinx Fanny , Brabant Christian , Bruyère Olivier , Durieux Nancy 
Published: August 2023

Objective:
The objective of this review is to synthesize the effects of nutritional counseling compared with no intervention (maintaining lifestyle habits) or nutritional counseling in combination with other interventions (eg, nutritional supplementation, physical activity) on physical performance and muscle strength in older adults.

Introduction:
Nutritional counseling, which is considered the first line of nutrition therapy, could play an important role in geriatric care programs by helping older adults understand the importance of nutrition and by promoting healthy, sustainable eating habits. However, the effects of nutritional counseling on physical function and muscle strength among older adults are not clear.

Inclusion criteria:
This review will consider randomized controlled trials and non-randomized controlled trials. Participants aged 65 years or older, who have received nutritional counseling alone or in combination with another intervention (eg, nutritional supplementation, physical exercise) will be considered for inclusion. Comparators will include another intervention or no intervention, but physical performance (ie, gait, endurance, balance) or muscle strength must be measured.

Methods:
This systematic review will be conducted in accordance with the JBI methodology for systematic reviews of effectiveness. The databases to be searched will include MEDLINE (Ovid), Embase, CENTRAL (Ovid), CINAHL (EBSCOhost), and Scopus. Sources of unpublished studies and gray literature will include Google Scholar and protocol registers. Two independent reviewers will select relevant studies, critically appraise the studies, and extract data. Studies will be pooled in a statistical meta-analysis or presented in narrative format. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach will be used to grade the certainty of the evidence.

Review registration:
PROSPERO CRD42022374527
Self-Supervised Learning of Spatially Varying Process Parameter Models for Robotic Finishing Tasks
Authors: Jung Yoon Yeo , Narayan Santosh V. , Gupta Satyandra K. 
Published: August 2023

Abstract
This article presents a self-supervised learning approach for a robot to learn spatially varying process parameter models for contact-based finishing tasks. In many finishing tasks, a part has spatially varying stiffness. Some regions of the part enable the robot to efficiently execute the task. On the other hand, some other regions on the part may require the robot to move cautiously in order to prevent damage and ensure safety. Compared to the constant process parameter models, spatially varying process parameter models are more complex and challenging to learn. Our self-supervised learning approach consists of utilizing an initial parameter space exploration method, surrogate modeling, selection of region sequencing policy, and development of process parameter selection policy. We showed that by carefully selecting and optimizing learning components, this approach enables a robot to efficiently learn spatially varying process parameter models for a given contact-based finishing task. We demonstrated the effectiveness of our approach through computational simulations and physical experiments with a robotic sanding case study. Our work shows that the learning approach that has been optimized based on task characteristics significantly outperforms an unoptimized learning approach based on the overall task completion time.
Comparison of Six Accelerometer Metrics for Assessing the Temporal Patterns of Children’s Free-Play Physical Activity
Authors: McKee Katherine L. , Pfeiffer Karin A. , Pearson Amber L. , Clevenger Kimberly A. 
Published: August 2023

Accelerometers are frequently used to measure physical activity in children, but lack of uniformity in data processing methods, such as the metric used to summarize accelerometer data, limits comparability between studies. The objective was to compare six accelerometer metrics (raw: mean amplitude deviation, Euclidean norm minus one, activity index, monitor-independent movement summary units; count: vertical axis, vector magnitude) for characterizing the intensity and temporal patterns of first and second graders’ (n = 88; age = 7.8 ± 0.7 years) recess physical activity. At a 5-s epoch level, Pearson’s correlations (r) between metrics ranged from .66 to .98. When each epoch was classified into one of four intensity levels based on quartiles, agreement between metrics as indicated by weighted kappa ranged from .81 to .96. When collapsed to time spent in each intensity level, metrics were strongly correlated (r = .76–.99) and most often statistically equivalent for estimating time spent in Quartile 3 or 4. Children were ranked from least to most active, and agreement between metrics was strong (Spearman’s correlation ≥ .87). Temporal patterns were characterized using five fragmentation indices calculated using each of the six metrics, which were fair-to-strongly correlated (r = .53–.99), with the strongest associations for number of high-intensity activity bouts (r ≥ .89). Most fragmentation indices were not statistically equivalent between metrics. While metrics captured similar trends in activity intensity and temporal patterns, caution is warranted when making comparisons of point estimates derived from different metrics. However, all metrics were able to similarly capture higher intensity activity (i.e., Quartile 3 or 4), the most common outcome of interest in intervention studies.