bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated smoking cessation and mood management following acute coronary syndrome: Protocol for the post-acute cardiac event smoking (PACES) trial
Authors: Adkins-Hempel Melissa , Japuntich Sandra J. , Chrastek Michelle , Dunsiger Shira , Breault Christopher E. , Ayenew Woubeshet , Everson-Rose Susan A. , Nijjar Prabhjot S. , Bock Beth C. , Wu Wen-Chih , Miedema Michael D. , Carlson Brett M. , Busch Andrew M. 
Published: May 2023

Abstract
Background
Approximately 400,000 people who smoke cigarettes survive Acute Coronary Syndrome (ACS; unstable angina, ST and non-ST elevation myocardial infarction) each year in the US. Continued smoking following ACS is an independent predictor of mortality. Depressed mood post-ACS is also predictive of mortality, and smokers with depressed mood are less likely to abstain from smoking following an ACS. A single, integrated treatment targeting depressed mood and smoking could be effective in reducing post-ACS mortality.

Method/design
The overall aim of the current study is to conduct a fully powered efficacy trial enrolling 324 smokers with ACS and randomizing them to 12 weeks of an integrated smoking cessation and mood management treatment [Behavioral Activation Treatment for Cardiac Smokers (BAT-CS)] or control (smoking cessation and general health education). Both groups will be offered 8 weeks of the nicotine patch if medically cleared. Counseling in both arms will be provided by tobacco treatment specialists. Follow-up assessments will be conducted at end-of-treatment (12-weeks) and 6, 9, and 12 months after hospital discharge. We will track major adverse cardiac events and all-cause mortality for 36 months post-discharge. Primary outcomes are depressed mood and biochemically validated 7-day point prevalence abstinence from smoking over 12 months.

Discussion
Results of this study will inform smoking cessation treatments post-ACS and provide unique data on the impact of depressed mood on success of post-ACS health behavior change attempts.

Trial registration

ClinicalTrials.gov, NCT03413423. Registered 29 January 2018. https://beta.clinicaltrials.gov/study/NCT03413423.
Early life adversity as a risk factor for cognitive impairment and Alzheimer’s disease
Authors: Huang Zhihai , Jordan J. Dedrick , Zhang Quanguang 
Published: May 2023

AbstractNeurological conditions, including cognitive impairment and Alzheimer’s disease (AD), impose a huge burden on society, affecting millions of people globally. In addition to genetic factors, recent studies indicate that environmental and experiential factors may contribute to the pathogenesis of these diseases. Early life adversity (ELA) has a profound impact on brain function and health later in life. In rodent models, exposure to ELA results in specific cognitive deficits and aggravated AD pathology. Extensive concerns have been raised regarding the higher risk of developing cognitive impairments in people with a history of ELA. In this review, we scrutinize findings from human and animal studies focusing on the connection of ELA with cognitive impairment and AD. These discoveries suggest that ELA, especially at early postnatal stages, increases susceptibility to cognitive impairment and AD later in life. In terms of mechanisms, ELA could lead to dysregulation of the hypothalamus-pituitary-adrenal axis, altered gut microbiome, persistent inflammation, oligodendrocyte dysfunction, hypomyelination, and aberrant adult hippocampal neurogenesis. Crosstalks among these events may synergistically contribute to cognitive impairment later in life. Additionally, we discuss several interventions that may alleviate adverse consequences of ELA. Further investigation into this crucial area will help improve ELA management and reduce the burden of related neurological conditions.
Venetoclax combined with daunorubicin and cytarabine (2 + 6) as induction treatment in adults with newly diagnosed acute myeloid leukemia: a phase 2, multicenter, single-arm trial
Authors: Suo Xiaohui , Zheng Fang , Wang Dongmei , Zhao Liyun , Liu Jie , Li Ling , Zhang Zhihua , Zhang Congcong , Li Yinling , Yang Sisi , Zhao Xuemei , Shi Rui , Wu Yan , Jiao Zongjiu , Song Jiaojie , Zhang Ling , Lu Xinxiao , Yuan Linyu , Gao Sifeng , Zhang Jilei , Zhao Xingli , Bai Guanchen , Liu Kaiqi , Mi Yingchang 
Published: May 2023

Abstract
Background
Venetoclax (Ven) combined with intensive chemotherapy was proven effective in the management of acute myeloid leukemia (AML). However, the severe and prolonged myelosuppression remains a concern to worry about. To explore more appropriate combination regimens, we designed Ven combining daunorubicin and cytarabine (DA 2 + 6) regimen as induction therapy, aimed to evaluate the effectiveness and safety in adults de novo AML.

Methods
A phase 2 clinical trial was performed in 10 Chinese hospitals to investigate Ven combined with daunorubicin and cytarabine (DA 2 + 6) in patients with AML. The primary endpoints were overall response rate (ORR), comprising of complete remission (CR), complete remission with incomplete blood cell count recovery (CRi), and partial response (PR). Secondary endpoints included measurable residual disease (MRD) of bone marrow assessed by flow cytometry, overall survival (OS), event-free survival (EFS), disease-free survival (DFS), and the safety of regimens. This study is a currently ongoing trial listed on the Chinese Clinical Trial Registry as ChiCTR2200061524.

Results
Overall, 42 patients were enrolled from January 2022 to November 2022; 54.8% (23/42) were male, and the median age was 40 (range, 16–60) years. The ORR after one cycle of induction was 92.9% (95% confidence interval [CI], 91.6–94.1; 39/42) with a composite complete response rate (CR + CRi) 90.5% (95% CI, 89.3–91.6, CR 37/42, CRi 1/42). Moreover, 87.9% (29/33) of the CR patients with undetectable MRD (95% CI, 84.9–90.8). Grade 3 or worse adverse effects included neutropenia (100%), thrombocytopenia (100%), febrile neutropenia (90.5%), and one mortality. The median neutrophil and platelet recovery times were 13 (5–26) and 12 (8–26) days, respectively. Until Jan 30, 2023, the estimated 12-month OS, EFS, and DFS rates were 83.1% (95% CI, 78.8–87.4), 82.7% (95% CI, 79.4–86.1), and 92.0% (95% CI, 89.8–94.3), respectively.

Conclusion
Ven with DA (2 + 6) is a highly effective and safe induction therapy for adults with newly diagnosed AML. To the best of our knowledge, this induction therapy has the shortest myelosuppressive period but has similar efficacy to previous studies.
Genomic insights into cryptic cycles of microbial hydrocarbon production and degradation in contiguous freshwater and marine microbiomes
Authors: Vigneron Adrien , Cruaud Perrine , Lovejoy Connie , Vincent Warwick F. 
Published: May 2023

AbstractBackgroundCyanobacteria and eukaryotic phytoplankton produce long-chain alkanes and generate around 100 times greater quantities of hydrocarbons in the ocean compared to natural seeps and anthropogenic sources. Yet, these compounds do not accumulate in the water column, suggesting rapid biodegradation by co-localized microbial populations. Despite their ecological importance, the identities of microbes involved in this cryptic hydrocarbon cycle are mostly unknown. Here, we identified genes encoding enzymes involved in the hydrocarbon cycle across the salinity gradient of a remote, vertically stratified, seawater-containing High Arctic lake that is isolated from anthropogenic petroleum sources and natural seeps. Metagenomic analysis revealed diverse hydrocarbon cycling genes and populations, with patterns of variation along gradients of light, salinity, oxygen, and sulfur that are relevant to freshwater, oceanic, hadal, and anoxic deep sea ecosystems.ResultsAnalyzing genes and metagenome-assembled genomes down the water column of Lake A in the Canadian High Arctic, we detected microbial hydrocarbon production and degradation pathways at all depths, from surface freshwaters to dark, saline, anoxic waters. In addition to Cyanobacteria, members of the phyla Flavobacteria, Nitrospina, Deltaproteobacteria, Planctomycetes, and Verrucomicrobia had pathways for alkane and alkene production, providing additional sources of biogenic hydrocarbons. Known oil-degrading microorganisms were poorly represented in the system, while long-chain hydrocarbon degradation genes were identified in various freshwater and marine lineages such as Actinobacteria, Schleiferiaceae, and Marinimicrobia. Genes involved in sulfur and nitrogen compound transformations were abundant in hydrocarbon producing and degrading lineages, suggesting strong interconnections with nitrogen and sulfur cycles and a potential for widespread distribution in the ocean.ConclusionsOur detailed metagenomic analyses across water column gradients in a remote petroleum-free lake derived from the Arctic Ocean suggest that the current estimation of bacterial hydrocarbon production in the ocean could be substantially underestimated by neglecting non-phototrophic production and by not taking low oxygen zones into account. Our findings also suggest that biogenic hydrocarbons may sustain a large fraction of freshwater and oceanic microbiomes, with global biogeochemical implications for carbon, sulfur, and nitrogen cycles.
Intensivist coverage and critically ill COVID-19 patient outcomes: a population-based cohort study
Authors: Oh Tak Kyu , Kim Saeyeon , Song In-Ae 
Published: May 2023

Abstract
Background
Trained intensivist staffing improves survival outcomes in critically ill patients at intensive care units. However, the impact on outcomes of critically ill patients with coronavirus disease 2019 has not yet been evaluated. We aimed to investigate whether trained intensivists affect outcomes among critically ill coronavirus disease 2019 patients in South Korean intensive care units.

Methods
Using a nationwide registration database in South Korea, we included adult patients admitted to the intensive care unit from October 8, 2020, to December 31, 2021, with a main diagnosis of coronavirus disease 2019. Critically ill patients admitted to intensive care units that employed trained intensivists were included in the intensivist group, whereas all other critically ill patients were assigned to the non-intensivist group.

Results
A total of 13,103 critically ill patients were included, with 2653 (20.2%) patients in the intensivist group and 10,450 (79.8%) patients in the non-intensivist group. In the covariate-adjusted multivariable logistic regression model, the intensivist group exhibited 28% lower in-hospital mortality than that of the non-intensivist group (odds ratio: 0.72; 95% confidence interval: 0.62, 0.83; P < 0.001).

Conclusions
Trained intensivist coverage was associated with lower in-hospital mortality among critically ill coronavirus disease 2019 patients who required intensive care unit admission in South Korea.
Modelling the seismic response of the Mýtina maar volcanic structure
Authors: Labuta Martin , Oprsal Ivo , Burjánek Jan 
Published: May 2023

AbstractIn this study, we determine the properties of the maar volcanic structure using ambient vibration analysis. We performed several ambient vibrations surveys at Mýtina maar (West-Bohemia, Czechia) to map amplification by site-to-reference spectral ratios and to estimate average shear wave velocities by array methods. As the maar diatreme is formed by a deep concave body of broken rock, strong 3D resonances develop. The site-to-reference amplification factors reach a value of 20 in the central part of the maar. Using the noise data, we demonstrate possibility of mapping the lateral dimensions of the maar infills by ambient noise measurements. To understand these observations, we developed a simplified 3D viscoelastic velocity model and simulated synthetic ambient vibrations by the finite difference method. The simulated response fitted both, measured fundamental frequencies and the amplification levels. The maximum depth of the crater was estimated to be at least 800 m.
Graphical Abstract
Regression analysis and variable selection to determine the key subduction-zone parameters that determine the maximum earthquake magnitude
Authors: Nakao Atsushi , Kuwatani Tatsu , Ueki Kenta , Yoshida Kenta , Yutani Taku , Hino Hideitsu , Akaho Shotaro 
Published: May 2023

AbstractLarge variations in the maximum earthquake magnitude ($$M_{{\text{max}}}$$

M
max

) have been observed among the world’s subduction zones. There is still no universal relationship between $$M_{{\text{max}}}$$

M
max

and a given subduction-zone parameter, such as plate age, plate dip angle, or plate velocity, which suggests that multiple parameters control $$M_{{\text{max}}}$$

M
max

. Here, we conduct exhaustive variable selections that are based on three evaluation criteria; leave-one-out cross-validation errors (LOOCVE), Akaike information criterion (AIC), and Bayesian information criterion (BIC) to determine the combination of subduction-zone parameters that best explains $$M_{{\text{max}}}$$

M
max

. Multiple linear regression analyses are applied using 18 subduction-zone parameters as potential candidates for the explanatory variables of $$M_{{\text{max}}}$$

M
max

. The minimum BIC is obtained when five variables (trench sediment thickness, existence of an accretionary prism, upper-plate crustal thickness, bending radius of the subducting oceanic plate, and trench depth) are selected as explanatory variables; each variable contributes positively to $$M_{{\text{max}}}$$

M
max

. Minimum LOOCVE and AIC values are obtained when eight variables (the five parameters for BIC, plus the along-strike plate convergence rate, age of the subducting plate, and maximum depth of the subducting plate) are selected. Our selection of the trench sediment thickness and plate bending radius contributing to $$M_{{\text{max}}}$$

M
max

is consistent with previous studies. The results show that increasing upper-plate crustal thickness results in a large $$M_{{\text{max}}}$$

M
max

. In addition to smoothing the subducting-plate interface via subducted sediments, along-dip extension of the crustal area along the convergent plate boundary would be important for generating a large earthquake.
Graphic Abstract
The feasibility of team care for women seeking to plan a vaginal breech birth (OptiBreech 1): an observational implementation feasibility study in preparation for a pilot trial
Authors: Walker Shawn , Spillane Emma , Stringer Kate , Meadowcroft Amy , Dasgupta Tisha , Davies Siân M. , Sandall Jane , Shennan Andrew ,   the OptiBreech Collaborative, Batish Avni , Davidson Louisa , Das Sabrina , Magurova Lenka , Haroun George , Meates Charlotte , Houghton Gillian , Grys Helen Le 
Published: May 2023

AbstractBackgroundOptiBreech Care is a care pathway for breech presentation at term, including where chosen, physiological breech birth attended by professionals with advanced training and/or proficiency. We aimed to assess the feasibility of implementing OptiBreech team care prior to proceeding with a planned pilot randomised controlled trial.MethodsOur design was an observational implementation feasibility assessment across England and Wales, January 2021–June 2022. Our objectives were to determine whether Trusts could provide attendants with advanced training (implementation feasibility), who deliver protocol-consistent care (fidelity), within existing resources (costs), while maintaining low neonatal admission rates (safety) and adequate recruitment rates (trial feasibility). Participants included women > 37 weeks pregnant with a breech-presenting foetus, requesting support for a vaginal breech birth following standard counselling, and staff involved in the study. No randomisation occurred in this first stage of feasibility work.ResultsThirteen National Health Service sites were recruited. A total of 82 women planned births in the study. Sites with a breech specialist midwife recruited at double the rate of sites without (0.90/month, 95%CI0.64–1.16 vs 0.40, 95%CI0.12–0.68). Referrals into the study came from midwives (46%), obstetricians (34%) and women themselves (20%). Vaginal births were attended by staff with OptiBreech training at 87.5% (35/40, 95%CI0.732–0.958) and by staff who met additional proficiency criteria at 67.5% (27/40, 95%CI0.509–0.814). Fidelity criteria were more consistently met by staff who also met proficiency criteria. There were four neonatal admissions (4.9%, 4/82), including one serious adverse outcome (1.2%, 1/82).ConclusionsA prospective observational cohort of OptiBreech collaborative care, which could potentially support nested or cluster randomisation, appears feasible in sites willing to establish a dedicated clinic and strategically develop further proficient members of staff, with back-up plans for supporting rapidly progressing births. Randomisation procedures remain to be feasibility tested. It is funded by the NIHR (NIHR300582).
Systematic braiding of Smoke-Free Home SafeCare to address child maltreatment risk and secondhand smoke exposure: findings from a pilot study
Authors: Self-Brown Shannon , Perry Elizabeth W. , Recinos Manderley , Cotner Michaela A. , Guastaferro Kate , Owolabi Shadé , Spears Claire A. , Whitaker Daniel J. , Huang Jidong , Kegler Michelle C. 
Published: May 2023

Abstract

Background
Exposure to secondhand tobacco smoke (SHS) and child maltreatment are preventable threats to child health. Few evidence-based interventions target both SHS and child maltreatment risk. The purpose of this paper is to describe the systematic braiding process of two evidence-based programs to address child SHS in the home and maltreatment perpetration risk, and present results from the formative work and pilot study.

Methods
The first 4 steps of the systematic braiding process were completed, including the following: (1) the identification of core elements of both programs, (2) the development of an initial draft of the braided curriculum (Smoke-Free Home SafeCare — SFH-SC), (3) an acceptability and feasibility pilot of SFH-SC with caregivers of young children who reported a smoker living in the home (N = 8), and (4) feedback collection on the braided curriculum from SafeCare Providers (N = 9).

Results
Experts identified common pedagogical and theoretical underpinnings for the two programs and braided Smoke-Free Homes: Some Things Are Better Outside into two SafeCare modules. Caregiver feedback from the pilot demonstrated that participants were engaged with SFH-SC and felt supported and comfortable discussing SHS intervention content with the SFH-SC Provider. Caregiver self-reports indicated a slight increase in smoke-free home rules from baseline to follow-up and a notable reduction in parent stress on the Parent Stress Index of 5.9 points (SD = 10.2). SafeCare Provider feedback following intensive review of the curriculum indicated high feasibility for SFH-SC delivery.

Conclusions
Parent and Provider findings suggest SFH-SC is a viable intervention that has potential to reduce the public health impact of SHS and child maltreatment for at-risk families.

Protocol
The protocol for the pilot is not published elsewhere; however, the full protocol for the hybrid trial can be found here: https://clinicaltrials.gov/ct2/show/NCT05000632.

Trial registration
NCT, NCT05000632. Registered 14 July 2021, there is not a separate registration number for the pilot.
Whole-exome sequencing detected a novel AIFM1 variant in a Han-Chinese family with Cowchock syndrome
Authors: Wang Chenyu , Lin Zhaojing , Yuan ZhuangZhuang , Tang Tieyu , Fan Liangliang , Liu Yihui , Wu Xuan 
Published: May 2023

AbstractCharcot-Marie-Tooth disease(CMT) is a hereditary peripheral neuropathy, characterized by progressive distal hypoesthesia and amyotrophia. CMT is characterized by an X- linked recessive inheritance pattern. The apoptosis-inducing factor mitochondria associated-1 (AIFM1) is the main pathogenic gene of the X-linked recessive Charcot-Marie-Tooth disease-4 with or without cerebellar ataxia (CMTX4), also known as Cowchock syndrome. In this study, we enrolled a family with CMTX from the southeast region of China and identified a novel AIFM1 variant (NM_004208.3: c.931C>G; p.L311V) using whole exon sequencing technology. The results of our study may also be useful for genetic counseling, embryo screening of in vitro fertilization embryos, and prenatal genetic diagnosis.
Ethnomedicinal plants used for the prevention and treatment of anemia in the Philippines: a systematic review
Authors: Magtalas Mariel C. , Balbin Patrick Tracy , Cruz Elljhay C. , Clemente Richard F. , Buan Ara Karizza G. , Garcia Jervy P. , Lee Ka Yiu , Tantengco Ourlad Alzeus G. 
Published: May 2023

Abstract
Background
Medicinal plants are still used in developing countries, including the Philippines, to treat common diseases in the community. Anemia is a common disease encountered in the community. It is characterized by a lower-than-normal level of red blood cell count. This systematic review identified the medicinal plants used for anemia treatment in the Philippines.

Methods
The study was conducted based on the PRISMA flow diagram, starting with a data search on electronic databases. The collected studies were screened based on the inclusion and exclusion criteria. The necessary information was extracted from the eligible research papers, and the studies’ quality was assessed through a developed quality assessment tool.

Results
A total of 20 ethnobotanical studies on medicinal plants used for anemia treatment were obtained from different provinces within the 12 regions of the Philippines. Most ethnobotanical studies were conducted in Region X (Northern Mindanao), CAR (Cordillera Administrative Region), and Region XIII (CARAGA), Philippines. The most common plant family is Convovulaceae, with nine records (21.95%), followed by Cucurbitaceae, with six records (14.63%), and Moringaceae, with five records (12.2%). The most common plant part used was the leaves. Others involved mixing different plant parts, with fruits and leaves being the most common combination. The most common route of administration utilized was drinking the decoction, followed by eating the plant. Most medicinal plants used to treat anemia in the Philippines had records of toxicologic (four species, 15.38%) or teratogenic (one species, 3.85%) properties. Eight plant species were reported as nontoxic (30.77%). In addition, ten plant species (38.46%) had no data on toxicity or teratogenicity.

Conclusion
There were only 20 ethnobotanical studies that documented the use of plants in treating anemia in the Philippines. This study listed several medicinal plants used in treating anemia in the Philippines. However, pharmacological and toxicological studies are still needed to determine their safety and efficacy in treating anemia in the community.