bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endometrial cancer risk and trends among distinct African descent populations
Authors: Medina Heidy N. , Penedo Frank J. , Joachim Clarisse , Deloumeaux Jacqueline , Koru‐Sengul Tulay , Macni Jonathan , Bhakkan Bernard , Peruvien Jessica , Schlumbrecht Matthew P. , Pinheiro Paulo S. 
Published: June 2023

AbstractBackgroundEndometrial cancer (EC) is the fourth most common cancer among Black women in the United States, a population disproportionately affected by aggressive nonendometrioid subtypes (e.g., serous, carcinosarcoma). To examine EC vulnerability among a wider spectrum of African descent populations, a comparison between Black women residing in different countries, rather than in the United States alone, is needed.MethodsThe authors analyzed 34,789 EC cases from Florida (FL) (2005–2018), Martinique (2005–2018), and Guadeloupe (2008–2018) based on cancer registry data. Age‐adjusted incidence rates, incidence rate ratios (IRRs), and annual percent changes (APC) in trends were estimated for Black populations residing in the United States (non‐Hispanic Blacks [NHB]) and Caribbean. The US non‐Hispanic White (NHW) population was used as a reference.ResultsCaribbean Black women had the lowest rates for endometrioid and nonendometrioid subtypes. Nonendometrioid types were most common among US (FL) NHBs (9.2 per 100,000), 2.6 times greater than NHWs (IRR, 2.60; 95% confidence interval [CI], 2.44–2.76). For endometrioid EC, rates increased 1.8% (95% CI, 0.1–3.5) yearly from 2005 to 2018 for US (FL) NHBs and 1.2% (95% CI, 0.9–1.6) for US (FL) NHWs whereas no change was observed for Caribbean Blacks. For nonendometroid carcinomas, rates increased 5.6% (95% CI, 4.0–7.2) among US (FL) NHB, 4.4% (95% CI, 0.3–8.6) for Caribbean Black, and 3.9% for US (FL) NHW women (95% CI, 2.4–5.5).ConclusionsLower rates of nonendometrioid EC among Caribbean Black women suggest that vulnerability for these aggressive tumor subtypes may not currently be an overarching African ancestry disparity. Most importantly, there is an alarmingly increasing trend in nonendometrioid across all populations studied, which warrants further surveillance and etiological research for this particular subtype.Plain Language Summary

We analyze population‐based incidence rates and trends of endometrial cancer (EC) for African descent populations residing in different countries (i.e., United States, Martinique, Guadeloupe) to examine whether EC vulnerability among Black women is socio‐environmental or more ancestry‐specific in nature.
The increased EC risk was not uniform across all Black women since the Caribbean had the lowest rates (for endometrioid and nonendometrioid histology subtypes).
Regardless, from 2005 to 2018, there was an increasing trajectory of nonendometrioid EC for all groups, regardless of race.
Cervicovaginal Papanicolaou tests in transgender men: Cytomorphologic alterations, interpretation considerations, and clinical implications
Authors: Torous Vanda F. 
Published: June 2023

AbstractBackgroundThe transgender population faces unique psychosocial and physical obstacles to cervical cancer screening. Additionally, most individuals undergo masculinizing testosterone hormone therapy, and the physiologic changes can cause cytomorphologic alterations that may mimic lesions. Although the literature on cervicovaginal cytology is growing in this patient population, it is still limited.MethodsThe pathology information system was queried for all Papanicolaou (Pap) tests from transgender men from January 2013 to February 2023. The original diagnostic categories were catalogued. Cases were reviewed to evaluate the cytomorphologic alterations. Clinical data were also sought, including whether the sample was self‐collected. Two comparison groups were established: one was a postpartum atrophic group and the other was an all‐comer group.ResultsA total of 51 cases from 43 individuals were identified, with a mean age of 31 years. Approximately a third of cases (18 of 51; 35%) were self‐collected. The abnormal rate was low, with 5.9% of cases rendered atypical squamous cells of undetermined significance on original review and no lesions identified. The Pap unsatisfactory rate according to original reports was 3.9%. This increased to 13.7% when the cases were rereviewed, which was significantly higher than the all‐comer comparison group. The unsatisfactory rate did not correlate with self‐collection. Atrophy was a prevalent cytomorphologic alteration, with the vast majority of cases (92%) showing at least mild atrophy. Small blue cells and transitional cell metaplasia were seen in many cases (53% and 43%, respectively).ConclusionsThere are clinical and morphologic considerations that are distinct to the transgender patient population. Laboratory personnel and diagnosticians need to be aware of these in order to optimize patient care.
NLOS node localization for improving warning message distribution in VANETS
Authors: Arunkumar R. S. , Chinnasamy A. 
Published: June 2023

SummaryVehicular Ad‐hoc Network (VANET) is a vehicle‐to‐vehicle communication technology, which is highly promising due to its continuous demand, applicability, and suitability for public safety. The vehicular nodes establish communication with each other for exchanging traffic data and road maps, especially when warning messages need to be broadcasted on the network during emergency situations. Therefore, accurate vehicle information is necessary in such circumstances to improve the accuracy of Non‐Line‐of‐Sight (NLOS) node localization. In this paper, a Driving Training‐Based Optimization for NLOS Node Localization (DTO‐NL) Scheme is proposed for facilitating better warning message delivery during emergency situations in vehicular networks through a dynamic increase and decrease in the search based on the position of unknown NLOS nodes from the considered anchor nodes employed for localization. The performance of the suggested technique has been analyzed based on parameters like warning message delivery rate, latency, localization error, channel utilization rate, energy consumption, and packet delivery ratio. The proposed DTO‐NL scheme enhances the warning message delivery rate by 9.81%, 11.28%, 14.38%, and 17.64% compared to WIDVBA , ROA‐APS , ILL‐WOA‐NLOS , and WDHPBDS techniques .
Eutectic Media Open a Synthetic Route to Oligocitrazinic Acid Fluorophores of Purple Hue
Authors: Schneider Helen , Strauss Volker , Vogl Sarah , Antonietti Markus , Filonenko Svitlana 
Published: June 2023

AbstractUnder isochoric and solvent‐free conditions, the reaction between ammonium formate and citric acid results in a deeply purple reaction product with fluorescent properties. This brings this reaction in the realm of bio‐based fluorophores and bottom‐up carbon nanodots from citric acid. The reaction conditions are optimized in terms of UV–vis spectroscopic properties and, subsequently, the main reaction product is separated. While the structural analysis does not give any indication for carbon nanodots in a general sense, it points towards the formation of molecular fluorophores that consist of oligomerized citrazinic acid derivatives. Furthermore, EPR spectroscopy reveals the presence of stable free radicals in the product. We hypothesize that such open‐shell structures may play a general role in molecular fluorophores from citric acid and are not yet sufficiently explored. Therefore, we believe that analysis of these newly discovered fluorophores may contribute to a better understanding of the properties of fluorophores and CND from citric acid in general.
Introduction to the Use of Linear and Nonlinear Regression Analysis in Quantitative Biological Assays
Authors: Jarantow Stephen W. , Pisors Eileen D. , Chiu Mark L. 
Published: June 2023

AbstractBiological assays are essential tools in biomedical and pharmaceutical research. In simplest terms, such an assay is an analytical method used to measure or predict a response in a biological system in the presence of a given stimulus (e.g., drug). The inherent complexity involved in evaluating a biological system requires the use of rigorous and appropriate tools for data analysis. Linear and nonlinear regression models represent critically important statistical analyses used to define the relationships between variables of interest in biological systems. Recent challenges relating to the reproducibility of published data suggest the absence of standardized and routine use of statistics to support experimental results across a wide range of scientific disciplines. The current situation warrants an introductory review of basic regression concepts using current, practical examples, along with references to in‐depth resources. The goal is to provide the necessary information to help standardize the analysis of biological assays in academic research and drug discovery and development, elevating their utility and increasing data transparency and reproducibility. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.
Co‐Doping of Al3+ and Ti4+ and Electrochemical Properties of LiNiO2 Cathode Materials for Lithium‐Ion Batteries
Authors: Wu Jinmei , Yang Jianwen , Zheng Jiawei , Wang Mengwen , Li Shengxian , Huang Bin , Li Yanwei , Zhu Qing , Chen Quanqi , Xiao Shunhua , Liu Botian 
Published: June 2023

AbstractLiNiO2 cathode material for lithium‐ion batteries has the advantages of high specific capacity, abundant resources, and low cost, but it suffers from difficulties in preparation, structural instability, and serious capacity decay. In this work, highly pure and layered structural LiNi0.95AlaTi0.05‐aO2 (a=0, 0.025, 0.05) cathode materials were synthesized by a simply sol‐gel method. The cation mixing of Ni2+ and Li+, structural deterioration, irreversible conversion between H2 and H3 phases and unstable surface and CEI (Cathode‐electrolyte interface) film can be effectively suppressed by co‐doping with Al3+ and Ti4+. A preferred LiNi0.95Al0.025Ti0.025O2 sample provides a discharge specific capacity of 223 mAh g−1 at 0.1 C and 148.32 mAh g−1 at 5 C, a capacity retention of 72.7 % after 300 cycles at 1 C and a Li+ diffusion coefficient of about 2.0×10−9 cm2 s−1.
Design, synthesis, anticancer evaluation, and in silico studies of some thieno[2,3‐d]pyrimidine derivatives as EGFR inhibitors
Authors: Sayed Menna Tallah M. , Halim Peter A. , El‐Ansary Afaf K. , Hassan Rasha A. 
Published: June 2023

AbstractNew series of 20 thieno[2,3‐d]pyrimidine derivatives have been synthesized. The National Cancer Institute evaluated all the newly synthesized compounds for their antiproliferative activity against a panel of 60 cancer cell lines. Compound 7b exhibited a remarkable antineoplastic activity at 10 µM dose and was therefore tested at five dose concentrations. The significant and broad‐spectrum antineoplastic action of compound 7b was observed against 37 of the tested cancer cell lines with a dose that inhibits 50% of the growth compared to control values in the micromolar range of 1.95–9.6 µM. The dose which inhibits the growth completely in the cytostatic range of 3.99–100 µM was also observed. Compound 7b effectively inhibited epidermal growth factor receptor (EGFR) with 50% inhibition concentration value (IC50) = 0.096 ± 0.004 compared to erlotinib with IC50 = 0.037 ± 0.002. Moreover, compound 7b revealed a powerful downregulation effect on total EGFR concentration and its phosphorylation. In addition, compound 7b inhibited phosphatidylinositol 3‐kinase, protein kinase B, and the mammalian target of rapamycin pathway phosphorylation. Furthermore, compound 7b raised total apoptosis by 21.93‐fold in the ovarian cancer cell line (OVCAR‐4) and caused an arrest in the cell cycle in the G1/S phase. It also raised the level of caspase‐3 by 4.72‐fold. Furthermore, to determine the binding manner of the most effective derivatives and validate their capacity to comply with the pharmacophoric properties necessary for EGFR inhibition, they were docked into the active site of the EGFR.
Using culturally significant birds to guide the timing of prescribed fires in the Klamath Siskiyou Bioregion
Authors: Long Linda L. , Lake Frank K. , Stephens Jaime L. , Alexander John D. , Ralph C. John , Wolfe Jared D. 
Published: June 2023

AbstractHistorically, wildfire and tribal burning practices played important roles in shaping ecosystems throughout the Klamath Siskiyou Bioregion of northern California and southern Oregon. Over the past several decades, there has been increased interest in the application of fire for forest management through the implementation of prescribed fires within habitats that are used by a diversity of migrant and resident land birds. While many bird species may benefit from habitat enhancements associated with wildfires, cultural burning, and prescribed fire, individuals may face direct or indirect harm. In this study, we analyzed the timing of breeding and molting in 11 species of culturally significant land birds across five ecologically distinct regions of northern California and southern Oregon to explore the potential timeframes that these bird species may be vulnerable to wildland fires (wildfire, prescribed fire, or cultural burning). We estimated that these selected species adhered to a breeding season from April 21 to August 23 and a molting season from June 30 to October 7 based on bird capture data collected between 1992 and 2014. Within these date ranges, we found that breeding and molting seasons of resident and migratory bird species varied temporally and spatially throughout our study region. Given this variability, spring fires that occur prior to April 21 and fall fires that occur after October 7 may reduce the potential for direct and indirect negative impacts on these culturally significant birds across the region. This timing corresponds with some Indigenous ecocultural burning practices that are aligned with traditionally observed environmental cues relating to patterns of biological phenology, weather, and astronomy. We detail the timing of breeding and molting seasons more specific to regions and species, and estimate 75%, 50%, and 25% quartiles for each season to allow for greater flexibility in planning the timing of prescribed fires and cultural burning, or regarding the potential implications of wildfires. The results of our study may serve as an additional resource for tribal members and cultural practitioners (when examined within the context of Indigenous Traditional Ecological Knowledge) and forest and wildland fire managers to promote stable populations of culturally significant bird species within fire‐dependent forest systems.
Large carnivore conservation and traditional pastoralism: A case study on bear–reindeer predation mitigation measures
Authors: Tallian Aimee , Støen Ole‐Gunnar , Immerzeel Bart , Kindberg Jonas , Ordiz Andrés , Persson Lars Thomas , Segerström Peter , Skarin Anna , Stokke Rune , Tveraa Torkild , Åhman Birgitta , Frank Jens 
Published: June 2023

AbstractWhile wildlife and cultural preservation goals can be either complimentary or counteractive, the goals of large carnivore conservation and traditional pastoralist lifestyles are often at odds. Livestock depredation can negatively impact the economies of livestock herders, while subsequent lethal removals contribute to local carnivore population declines. Here, we collaborated with two Sámi reindeer herding communities (2010–2016) situated in Sweden's boreal forest to evaluate the efficacy and economic feasibility of three brown bear predation mitigation measures: corralling pregnant reindeer during parturition, lethal bear management removals, and public bear‐license hunting. Calving corrals increased survival for reindeer calves born to average‐sized females by 7%–15%, and by 14%–30% for calves born to small females. However, the realized cost of implementing calving corrals outweighed the financial gain for both our study areas (net losses ranged between €1111 and €6210 per calf saved from bear predation per year when using the updated 2021 calf value; 1€ [Euro] = US$1.1), as well as for almost every theoretical scenario we explored (net losses €234 and €13,995 per calf saved from bear predation). The exception was the theoretical scenario where small herding communities overlapped large bear populations, which crossed the breakeven efficacy bear/reindeer ratio of 13.5 bears/100 reindeer and had a potential net gain of €36 per saved calf. Similarly, the cost of lethal management removals of bears outweighed the potential financial gain from saved calves, with net losses between €75 and €239 per calf. License hunting, where the hunters voluntarily incur the monetary costs of removing bears, is in most cases the only economically viable mitigation measure where the cost of mitigation did not outweigh the financial gain from increased reindeer survival. While the annual public license hunt was the most cost‐effective mitigation measure, it may be less biologically effective, that is, bear hunting occurs in the fall and reindeer parturition the following spring which leaves time for the empty niche of harvested bears to be filled by survivors. Economically and biologically effective predation mitigation measures are key for promoting coexistence, and we suggest that potential mitigation measures should be studied in collaboration with local people.
Dynamic behaviour and seismic response of structures isolated with low shape factor bearings
Authors: Orfeo Alessandra , Tubaldi Enrico , Muhr Alan H. , Losanno Daniele 
Published: June 2023

AbstractThis study investigates the mechanical behaviour of laminated elastomeric bearings with a low shape factor (LSF) and the dynamic response of structures mounted on them. Axial loads have a significant influence on the mechanical behaviour of the LSF bearings. Most of the existing theories and mechanical models for laminated bearings cannot be employed for LSF bearings because they disregard the important effects of axial shortening and bulging of the rubber layers on the horizontal bearing stiffness.In this study, a simplified model originally developed for slender rubber blocks is employed for describing the mechanical behaviour of LSF bearings, and validated against the experimental results on low‐damping LSF bearings manufactured and tested at Tun Abdul Razak Research Center (TARRC). The proposed model is then used to simulate the seismic response of a structural prototype mounted on the low‐damping LSF bearings and tested at University of Naples Federico II on a shaking table under horizontal seismic input. Further analyses are carried out to evaluate how the bearing shape factor affects the dynamic and seismic response of the prototype. The study provides some useful insight into the complex mechanical behaviour of LSF bearings and of structures mounted on them.
Development of an automated mobile grain size mapping of a mixed sediment beach
Authors: Matsumoto Hironori , Young Adam P. 
Published: June 2023

AbstractGrain sizes influence beach morphologies, processes, and states (e.g., dissipative, reflective and intermediate), however previous studies analysing beach grain size are often spatially and temporarily sparse. In this study, an automated mobile grain size estimation method using digital photographs (mobile digital grain size, MDGS) was developed and tested at a mixed sediment beach consisting of sand and gravels. The data collection system consisted of a downward‐looking camera, Real Time Kinematic Global Navigation Satellite System, and a camera‐triggering single‐board computer, attached to an all‐terrain vehicle. Digital photographs were collected monthly from January 2021 to March 2022 over a section spanning ~700 m alongshore and processed automatically using an existing (non‐mobile) DGS estimation method. The MDGS results were generally consistent with manually estimated grain sizes (n = 962, r2 = 0.74, RMSE = 5.9 mm) and UAV orthomosaic imagery, although the MDGS sometimes overestimated manually estimated grain sizes particularly for photographs with relatively small sediments. Modelled nearshore waves and subaerial beach survey data from mobile terrestrial LiDAR were used to explore using MDGS in morphological studies. Seasonal grain size trends, observed relationships between nearshore wave height and spatially averaged beach grain size, and the general increasing trends of grain sizes with both beach elevation and local roughness/slope were consistent with previous studies, highlighting the use of MDGS for morpho‐sedimentary mixed sediment beach research. The MDGS provides a unique method to conduct spatially and temporarily high‐resolution mapping of gravel size sediments over large areas (>102 m alongshore). Potential improvements of the MDGS include additional low elevation cameras for improved fine (e.g., sand) grain size estimates, decreased time between photo triggering, and automated removal of erroneous photographs containing surface irregularities (e.g., tire tracks) and non‐sediment features (e.g., seaweed). Overall, the MDGS provides improved surface grain size mapping and investigations of complex grain size–morphology relationships of mixed sediment beaches.
Miquelianin, a main functional flavonoid of lotus leaf, induces thermogenic signature via p38‐PINK1‐PARKIN‐mediated mitophagy and mimicking NRF2 signaling during brown adipocyte differentiation
Authors: Wang Zhenyu , Xue Chaoyi , Yang Tian , Zeng Maomao , Wang Zhaojun , Chen Qiuming , Chen Jie , He Zhiyong 
Published: June 2023

AbstractAdipocytes thermogenesis is an important mechanism for increasing energy expenditure. Here, screening of thermogenic activators (Sirt1 and Ucp1) investigated in C3H10T1/2 cells revealed ethanol extract of lotus leaf (LLE) may exert higher activity compared with that of the other 11 ingredients. UPLC‐MS/MS analysis showed that miquelianin was identified as the main flavonoid compounds in LLE (12.8%) and therefore deserves further investigation. The results in C3H10T1/2 cells revealed miquelianin promoted lipolysis, enhanced thermogenic programming (Sirt1, Ppargc1a, Prdm16, Cox7a, Nrf1, Cox2, and Ucp1), and induced brown‐like adipocyte formation (Fgf21, Cd137, Tmem26, Tbx1, Cd40, and Cited1). Moreover, miquelianin increased mitochondrial abundance, mitochondrial membrane potential, and NAD+/NADH ratio, suggesting its potential in mitochondria activity. We also observed that miquelianin improved mitochondrial quality by the establishment of mitochondrial dynamics (Mfn1, Mfn2, Opa1, Drp1, and Fis1) and subsequent suppression of autophagy. Chemical inhibition experiment revealed miquelianin may trigger browning via p38‐PINK1‐PARKIN‐mediated mitophagy. Furthermore, in ML385‐treated cells, NRF2, HMOX1, TFAM, and UCP1 were compromised by miquelianin treatment, suggesting that NRF2 signaling is necessary during miquelianin‐induced mitochondria biogenesis. Together, our findings demonstrate that miquelianin may induce browning and mitochondria thermogenic programing by suppressing mitophagy via p38‐PINK1‐PARKIN and mimicking NRF2 signaling.
A two‐way coupling 2D‐3D hybrid finite element numerical model using overlapping method for tsunami simulation
Authors: Ling Guoming , Matsumoto Junichi , Kashiyama Kazuo 
Published: June 2023

AbstractThis paper describes a 2D‐3D hybrid model for tsunami simulations that uses an overlapping method based on an arbitrary grid. A 2D model is used to simulate wave propagation from the source area to the offshore area, and a 3D model is then used to simulate the free surface flow around structures in coastal areas. An overlapping method that satisfies the conservation and compatibility conditions is developed to couple the two models. The shallow water equations are applied for the 2D model, and the Navier‐Stokes equations and continuity equations are applied for the flow field of the 3D model. The Allen‐Cahn equation is applied for the interface‐capturing method of the 3D model. The stabilized finite element method is applied for the spatial discretization and the Crank‐Nicolson method is used for the temporal discretization of the governing equations. The model is verified and validated through several numerical analysis examples.