bluuebunny/crossref_metadata_2025_split huggingface dataset:
Between Faith and Works
Authors: Vaucanson Bastian Felter 
Published: March 2023

AbstractThis article elucidates François Fénelon's (1651–1715) conception of monarchical charity by connecting it with earlier conceptions of charity, especially that of François de Sales (1567–1622). It discusses three topoi of devotional literature that it presents as addressing the tension between faith and works: the value of obedience, the notion of the ignorant saint, and the notion of a spiritual elite. It then argues that Sales gives considerable weight to charitable actions performed out of obedience to God, often against one's own inclination and without regard for self-interest. On the premise that Fénelon's princely ideal should not be separated from the concerns of his spiritual writings, the article argues that Fénelon saw a ruler who sacrifices his pleasures and self-interest to his care for his people as an embodiment of the Salesian conception of charity.
Gladys Peake Guevara: veinte años de liderazgo de la enfermería chilena de la segunda mitad del siglo XX
Authors: Castillo Lucia 
Published: March 2023

Introducción: La historia de la salud posee numerosos hitos protagonizados por mujeres anónimas conformando un vacío historiográfico de aquellas figuras femeninas que han aportado a las políticas sanitarias.
Objetivo: Relevar la figura de Gladys Peake como destacada enfermera chilena y latinoamericana contribuyendo a la construcción de un cuerpo epistemológico profesional de mujeres.
Métodologia: Histórico-biográfico a partir de la revisión de fuentes primarias documentales y relatos de fuentes secundarias sometidos a análisis temático y analizados bajo los supuestos teóricos de la interseccionalidad.
Resultados: Emergieron tres categorías de análisis: Gladys Peake como articuladora de la profesionalización de la enfermería chilena, como Sub-Jefa del Sub-departamento de Enfermería y su accionar durante el quiebre institucional durante la dictadura de Augusto Pinochet.
Conclusiones: Gladys Peake fue una líder que se posicionó como referente de la enfermería nacional, y en su gestión, reprodujo las prácticas propias de un momento de plena crisis institucional en pro del desarrollo de la enfermería chilena. Sin embargo, supo sobreponer su identidad profesional por sobre su ideología, dando cuenta del potencial político de las mujeres enfermeras.
Electronic cigarettes for smoking cessation in pregnancy: a nation–wide mixed methods study
Authors: Broadfield Amy , Ayre Helen , Ahmadi Keivan 
Published: March 2023

Background/Aims The use of electronic cigarettes for smoking cessation during pregnancy is supported by Public Health England and the Royal College of Midwives. However, their long-term effects remain largely unknown. The aim of this study was to explore midwives’ knowledge of and attitudes to electronic cigarette use in pregnancy, and whether this affected their recommendation for their use in smoking cessation. Methods An online survey was distributed to 122 qualified midwives in England. Participants were scored on their knowledge of and attitude to electronic cigarettes and their use in pregnancy. The study was cross-sectional and responses were subjected to analytical and descriptive statistical analysis. Results There was a significant indirect association between knowledge and attitude, where an increase in knowledge was associated with a more negative attitude (P≤0.001). There was a significant association between attitude, knowledge and personal practice. Categories identified from qualitative data were ‘not enough or no training/information/resources provided’ and ‘not enough research has been done’. Conclusions Midwives’ practice in supporting electronic cigarette use as a smoking cessation strategy is influenced by their knowledge and attitude, as well as by challenges in implementing recommendations in practice. This highlights the perceived need for more research on the potential risks and benefits, as well as more resources.
Oral cancer and tobacco cessation: what’s your role?
Authors: Wake Charlotte 
Published: March 2023

Charlotte Wake outlines how to aid patients in smoking cessation and patients oral care. Aim To increase knowledge of tobacco use, its effects on oral cancer and how we can help our patients to stop their tobacco use. Objectives To have a better understanding of the different types of tobacco To have knowledge of the five A‘s’ of tobacco cessation To know where we can gain information to refer patients to local smoking cessation clinics This article meets GDC development outcomes B,C,D
Investigation of in-phase bilateral exercise effects on corticospinal plasticity in relapsing remitting multiple sclerosis: A registered report single-case concurrent multiple baseline design across five subjects
Authors: Sokratous Dimitris , Charalambous Charalambos C. , Papanicolaou Eleni Zamba , Michailidou Kyriaki , Konstantinou Nikos 
Published: March 2023

Relapsing-remitting Multiple Sclerosis is the most common demyelinating neurodegenerative disease and is characterized by periods of relapses and generation of various motor symptoms. These symptoms are associated with the corticospinal tract integrity, which is quantified by means of corticospinal plasticity which can be probed via transcranial magnetic stimulation and assessed with corticospinal excitability measures. Several factors, such as exercise and interlimb coordination, can influence corticospinal plasticity. Previous work in healthy and in chronic stroke survivors showed that the greatest improvement in corticospinal plasticity occurred during in-phase bilateral exercises of the upper limbs. During in-phase bilateral movement, both upper limbs are moving simultaneously, activating the same muscle groups and triggering the same brain region respectively. Altered corticospinal plasticity due to bilateral cortical lesions is common in MS, yet, the impact of these type of exercises in this cohort is unclear. The aim of this concurrent multiple baseline design study is to investigate the effects of in-phase bilateral exercises on corticospinal plasticity and on clinical measures using transcranial magnetic stimulation and standardized clinical assessment in five people with relapsing-remitting MS. The intervention protocol will last for 12 consecutive weeks (30–60 minutes /session x 3 sessions/week) and include in-phase bilateral movements of the upper limbs, adapted to different sports activities and to functional training. To define functional relation between the intervention and the results on corticospinal plasticity (central motor conduction time, resting motor threshold, motor evoked potential amplitude and latency) and on clinical measures (balance, gait, bilateral hand dexterity and strength, cognitive function), we will perform a visual analysis and if there is a potential sizeable effect, we will perform statistical analysis. A possible effect from our study, will introduce a proof-of-concept for this type of exercise that will be effective during disease progression.
Trial registration: ClinicalTrials.gov NCT05367947.
Performance of bedside tools for predicting infection-related mortality and administrative data for sepsis surveillance: An observational cohort study
Authors: Bateson Meghan , Marwick Charis A. , Staines Harry J. , Patton Andrea , Stewart Elaine , Rooney Kevin D. 
Published: March 2023

BackgroundMeasuring sepsis incidence and associated mortality at scale using administrative data is hampered by variation in diagnostic coding. This study aimed first to compare how well bedside severity scores predict 30-day mortality in hospitalised patients with infection, then to assess the ability of combinations of administrative data items to identify patients with sepsis.MethodsThis retrospective case note review examined 958 adult hospital admissions between October 2015 and March 2016. Admissions with blood culture sampling were matched 1:1 to admissions without a blood culture. Case note review data were linked to discharge coding and mortality. For patients with infection the performance characteristics of Sequential Organ Failure Assessment (SOFA), National Early Warning System (NEWS), quick SOFA (qSOFA), and Systemic Inflammatory Response Syndrome (SIRS) were calculated for predicting 30-day mortality. Next, the performance characteristics of administrative data (blood cultures and discharge codes) for identifying patients with sepsis, defined as SOFA ≥2 because of infection, were calculated.ResultsInfection was documented in 630 (65.8%) admissions and 347 (55.1%) patients with infection had sepsis. NEWS (Area Under the Receiver Operating Characteristic, AUROC 0.78 95%CI 0.72–0.83) and SOFA (AUROC 0.77, 95%CI 0.72–0.83), performed similarly well for prediction of 30-day mortality. Having an infection and/or sepsis International Classification of Diseases, Tenth Revision (ICD-10) code (AUROC 0.68, 95%CI 0.64–0.71) performed as well in identifying patients with sepsis as having at least one of: an infection code; sepsis code, or; blood culture (AUROC 0.68, 95%CI 0.65–0.71), Sepsis codes (AUROC 0.53, 95%CI 0.49–0.57) and positive blood cultures (AUROC 0.52, 95%CI 0.49–0.56) performed least well.ConclusionsSOFA and NEWS best predicted 30-day mortality in patients with infection. Sepsis ICD-10 codes lack sensitivity. For health systems without suitable electronic health records, blood culture sampling has potential utility as a clinical component of a proxy marker for sepsis surveillance.
Quality evaluation of the Azithromycin tablets commonly marketed in Adama, and Modjo towns, Oromia Regional State, Ethiopia
Authors: Mekasha Yesuneh Tefera , Chali Belachew Umeta , Feissa Anbessa Bekele , Godena Gemmechu Hasen , Hassen Hassen Kebede , Wega Sultan Suleman 
Published: March 2023

Background
Azithromycin is a therapeutically” relevant macrolide antibiotic registered on the Essential Medicines List of the World Health Organization. The fact that medicine is selected as an essential drug doesn’t mean that it is of good quality. Hence, a continuous quality evaluation of the drug should be mandated to verify that the right medication is available on the market.

Objective
To evaluate the quality of Azithromycin Tablets commonly marketed in Adama, and Modjo town, Oromia Regional State, Ethiopia.

Methods
All six brands were subjected to in-vitro quality control tests, which were carried out according to procedures described in the manufacturer’s method, the United States Pharmacopeia, and the WHO inspection tool. All quality control parameters were compared by one-way ANOVA. Statistically, significant difference was considered when P<0.05. The in-vitro dissolution profiles of the brands were also compared statistically using the post-hoc Dunnett test, model-independent and model-dependent approaches.

Results
All of the evaluated brands agreed with WHO visual inspection criteria. All of the tablets achieved the thickness, and diameter test requirements of the manufacturer’s specification (±5%). All brands passed the hardness, friability, weight variation, disintegration, identity, and assay tests as stipulated by USP. The dissolution rate was more than 80% in 30 minutes, which was within the USP specification. The model-independent parameters have confirmed that only two brands (2/6) were deemed better brands for interchangeability. Weibull and Korsemeyer’s Peppas model were the best release models.

Conclusion
All of the evaluated brands passed the quality specification. The model dependent approaches revealed that drug release data fit well to the Weibull, and Korsemeyer’s Peppas release models. However, the model-independent parameters have confirmed that only two brands were deemed better brands (2/6) for interchangeability. Due to the dynamic nature of low-quality medications, the Ethiopian Food, and Drug Authority should keep an eye on marketed products to guarantee their quality, especially for drugs like azithromycin for which non-bioequivalence data from the study has revealed a clinical concern.
Provision and delivery of survivorship care for adult patients with haematological malignancies: A scoping review protocol
Authors: Baldwin Zoe-Anne V. , Busby Steph , Allsup David , Cohen Judith , Bamidele Olufikayo 
Published: March 2023

Introduction
Haematological malignancies are a heterogenous group of blood and lymphatic cancers. Survivorship care is a similarly diverse term concerning patients’ health and wellbeing from diagnosis to end of life. Survivorship care for patients with haematological malignancies has traditionally been consultant-led and secondary care-based, although shifts away from this model have been occurring, largely via nurse-led clinics and interventions with some remote monitoring. However, there remains a lack of evidence regarding which model is most appropriate. Although previous reviews exist, patient populations, methodologies, and conclusions are varied, and further high-quality research and evaluation has been recommended.

Aims
The aim of the scoping review this protocol describes is to summarise current evidence on the provision and delivery of survivorship care for adult patients diagnosed with a haematological malignancy, and to identify existing gaps to inform future research.

Methodology
A scoping review will be carried out utilising Arksey and O’Malley’s guidelines as its methodological framework. Studies published in the English language from December 2007 to the present will be searched on bibliographic databases, including Medline, CINAHL, PsycInfo, Web of Science, and Scopus. Papers’ titles, abstracts, and full text will predominantly be screened by one reviewer with a second reviewer blind screening a proportion. Data will be extracted using a customised table developed in collaboration with the review team, and presented in tabular and narrative format, arranged thematically. Studies included will contain data regarding adult (25+) patients diagnosed with any haematological malignancy in combination with aspects related to survivorship care. The survivorship care elements could be delivered by any provider within any setting, but should be delivered pre- or post-treatment, or to patients on a watchful waiting pathway.

Registration
The scoping review protocol has been registered on the Open Science Framework (OSF) repository Registries (https://osf.io/rtfvq; DOI: 10.17605/OSF.IO/RTFVQ).
Recurrent Gastrointestinal Pseudo-obstruction Because of Well-Differentiated Duodenal Neuroendocrine Tumor
Authors: Sharma Ruchi , Zafar Hammad , Sherman Scott K. , Niyazi Fadi 
Published: March 2023

ABSTRACT
A 56-year-old man presented with recurrent gastrointestinal obstruction. Computed tomography showed fluid-filled, distended stomach, small intestine, and large intestine. Extensive workup including esophagogastroduodenoscopy, colonoscopy, magnetic resonance enterography, push enteroscopy, and video capsule enteroscopy showed no mechanical obstruction. Endoscopic ultrasound–guided biopsy of peripancreatic nodes detected on 18F-fluorodeoxyglucose positron emission tomography revealed a duodenal neuroendocrine tumor. The lesion showed intense uptake on gallium-68 DOTATOC positron emission tomography-computed tomography scan. The patient underwent surgical resection of the tumor with resolution of bowel obstruction events. He had elevated pancreatic polypeptide levels, which are known to delay gastric emptying and could explain his symptoms.
Breast Cancer Metastasis to the Gastrointestinal Tract With Unusual Endoscopic and Histologic Presentations
Authors: Kimchy Alexandra V. , Umoren Mfonsio D. , Rosenberg Jessica J. , Ilagan Charmaine , Nithagon Pichayut , Shafa Shervin , Jennings Joseph J. 
Published: March 2023

ABSTRACT
The gastrointestinal (GI) tract is an infrequent site of breast cancer metastasis, but it often poses a diagnostic challenge when it occurs. The symptoms of GI metastases are often nonspecific, and the endoscopic manifestations are variable, requiring tissue biopsies for histologic examination. We report 2 cases of breast cancer metastasizing to the GI tract: a case of human epidermal growth factor receptor 2-positive invasive ductal carcinoma that metastasized to the stomach, a rare location for this histologic subtype, and another case of invasive lobular cell carcinoma that metastasized to the colon with unusual findings of mucosal pallor and edema on colonoscopy.
Adult-Onset Primary Intestinal Lymphangiectasia With Liver Enzymes Elevation
Authors: Nguyen Chuong Dinh , Buchman Alan , Bui Hoang Huu , Thi-Lan Pham Anh , Thi-Ngoc Vo Diem , Dang Luan Minh , Vo Van Huy 
Published: March 2023

ABSTRACT
Primary intestinal lymphangiectasia is a rare disorder that may result in protein-losing enteropathy. We report a 21-year-old man with malabsorption syndrome, an unintentional weight loss of 30 kg over 10 months, lymphocytopenia, and hepatic aminotransferase elevation. His diagnosis was established by a combination of enteroscopy, histopathology, and secondary etiology exclusion. Institution of parenteral nutrition, followed by a low-fat diet, medium-chain triglycerides, and octreotide, resulted in the resolution of his symptoms and laboratory abnormalities and led to weight gain. Aminotransferase abnormalities are an atypical finding in primary intestinal lymphangiectasia and were most likely due to nonalcohol steatohepatitis after rapid weight loss. Primary intestinal lymphangiectasia should be considered in patients with protein-losing enteropathy and lymphocytopenia.
Hepatic Perivascular Epithelioid Cell Tumor Mimicking Hepatocellular Carcinoma
Authors: Harwal Rahul , Joseph Rosemary Livin Jose , Raju Prabhakaran , Chidambaranathan Sugumar , Bharathi Vidya Jayanthi J. , Obla Lakshmanamoorthy Naganath Babu 
Published: March 2023

ABSTRACT
Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal neoplasms, and liver PEComas are extremely rare. They are usually discovered incidentally, and diagnostic pitfalls are frequent owing to similar imaging characteristics to other liver neoplasms. We present a patient whose evaluation was consistent with a right-sided hepatocellular carcinoma for which right hepatectomy was performed. Based on the final histopathological examination and immunohistochemistry, a diagnosis of PEComa was made. Immunohistochemistry plays a crucial role in arriving at the diagnosis, and resection represents the standard of care. A long-term follow-up is recommended because the natural history of PEComas is unpredictable.
Ações coordenadas em experiências no ensinar e no aprender online
Authors: Silva Raquel Silveira da , Juliano Andréa Nóbrega , Laurino Débora Pereira 
Published: March 2023

Mesmo que imersas em atividades proporcionadas pelas tecnologias digitais, percebemos que a maioria das instituições ainda são constituídas em sua estrutura e nos currículos de seus cursos para atender os estudantes de forma presencial. O surto do Coronavírus Disease 2019 (COVID-19), e a necessidade de isolamento social impulsionou o repensar e a criação de alternativas para a nova realidade. Cartografamos a experiência de propor ações coordenadas na disciplina Educação Matemática e Docência III de um curso de Matemática-Licenciatura como uma maneira de compreender e avaliar o aprender dos estudantes. Observar a turma e o contexto, estabelecer os critérios de avaliação juntamente com os estudantes o torna corresponsável pelo seu aprender. As ações coordenadas corroboraram com o adensamento e a produção gradual de argumentos referentes aos temas estudados, percebidos pelo acompanhamento das atividades. Direcionamos nossos olhares para as experiências e interações pela escrita expressas em ações coordenadas no contexto da educação online.
Rhino-Orbito-Cerebral Mucormycosis (ROCM): An Observational Case Report of Covid-19 Positive Patients Admitted in Intensive Care Unit of Community Hospital in South India
Authors: Nwadinigwe Chimezie Finian , Adi Mateus Sakundarno , Laksono Budi , Sutiningsih Dwi 
Published: March 2023

Background: Rhino-orbito-cerebral mucormycosis (ROCM) increasing incidence in the setting of COVID-19 in India and elsewhere has become a matter of immediate concern. In this observational case report we have observed the signs and symptoms of ROCM among coronavirus positive patients with reference to “Mucor code “as reported by Honavar SG 2021, we have reported cases been admitted to ICU for <2weeks in a community hospital in South India. Method: Patient informed consent was taken, Patient’s data (Medical record, medication charts, daily report) were collected using a designed data collection form, observed warning signs and symptoms, and predisposed factors was noted and ROCM is characterized with reference to the “Mucor code”.Results: Nasal stuffiness, Foul smell and Facial pain and among others were the most coherent warning signs and symptoms observed among the patients in <2weeks of admission in ICU. Other observed predisposing risk factors were regular administration of corticosteroids, antibiotics, Diabetes Mellitus, Hypertension, and Kidney Stone.Conclusion: All the cases on preliminary examination on the basis of observed warning signs and symptoms were “Possible” ROCM a sub-type of Covid-19 associated mucormycosis (CAM), as this was the first reported case of the hospital. Our study gave basis for further diagnosis and monitoring of Covid-19 positive patient admitted in the intensive care units.
Safety of Health Care Workers A Priority for Patient Safety
Authors: Hussein Maiga Ayub , Sutiningsih Dwi , Frida Chebet 
Published: March 2023

Background: Worldwide healthcare workforce represents 12%, in Uganda, out of the 39000 healthcare workers (HCW), 500 have been deployed at Mbale regional referral hospital (MRRH). The deficient quality service delivery is attributed to adverse occupational health risk that are not addressed and acknowledged posing a great risk to patient safety. Study aims to investigate the unsafe acts and unsafe working conditions of health care workers at (MRRH).Methods: A quantitative observational study with a cross-section design was used using and a semi structured observation checklist for data collection among 120 health care workers of MRRH.Result: 45(37.5%) of the HCW never wore the necessary PPEs versus 75(62.5%) who wore, almost half 55(45.3%) worked over time and 65(54.6%) did not, as well the same figures represent those who over worked and those who did not over work respectively. 70% of the working places had defective working conditions for example no lighting, slippery floors and no danger signs. 75% of the wards had improper waste segregation measures.Conclusion : HCW and institutions should intervene to mitigate the hazards, strengthening occupational health, patient safety, hazard prevention and control