bluuebunny/crossref_metadata_2025_split huggingface dataset:
BABS (Becoming Active in Beating osteoarthritiS): Study protocol of a randomized controlled trial on the effectiveness of an information campaign in improving the management of osteoarthritis and quality of care
Authors: Oomen J. M.H. , Schers H. J. , Das E. , Koëter S. , Ende C. H. , Assendelft W. J.J. 
Published: April 2023

Abstract
Background
Despite recommendations, non-surgical treatment modalities in knee and/or hip osteoarthritis (KHOA) are underused. This article describes the development and content of an information campaign and the design of a randomized controlled trial (RCT) on the effectiveness of such a information campaign, targeting both KHOA patients and healthcare professionals (HCPs), on healthcare utilization.
Methods
The Behaviour Change Wheel (BCW) was used as a theoretical framework for the campaign design. After an inventory of the literature, a selection was made of factors influencing healthcare use. The campaign aims to increase 1) awareness and knowledge of patients and their HCPs about OA and treatment options, and 2) quality of communication and interdisciplinary collaboration. Main elements of the campaign include written materials and an educational program. Persuasive communication techniques (i.e., message framing, narratives) are embedded within the campaign to positively impact beliefs about conservative treatments. The effectiveness of the campaign will be evaluated with a cluster RCT. The study aims to recruit 300 patients in 24 general practices (GPs), randomly allocated to intervention or usual care (ratio 1:1). GPs and affiliated HCPs are invited to participate in the trial and recruit patients. Patients are eligible to participate if they are Dutch speaking, aged 50 to 75, registered with KHOA at the GP practice, without joint replacement nor having considerable walking impairment. The main endpoint is the difference in rate of referral to hospital care as reported by patients over a period of 18 months. Secondary parameters include quality of care, beliefs about KHOA treatment modalities, physical activity, self-management behavior, and referral rates to secondary care. Patients receive online questionnaires at baseline, 6, 12, and 18 months. Online questionnaires are sent to HCPs at baseline and after 12 months to assess (changes in) beliefs about KHOA treatment modalities, and qualitative interviews are performed with HCPs of the intervention group at 12 months to assess network collaboration.
Conclusion
This article reports on a systematic, theory-based approach, building a toolbox of evidence-based intervention strategies. Furthermore, the RCT will provide insight into the effectiveness of an information campaign on impacting patterns of healthcare consumption.
Trial registration
International Clinical Trial Registry Platform (ICTRP), trial number NL9140, registration date 23-12-2020
Virtual Audio Design Based on Mobile Sensor Network and English MOOC Teaching
Authors: Wang Fang 
Published: April 2023

Abstract
The continuous emergence of virtual reality also makes people think about vigorously developing digital audio and scientific image technology. The volume return and audio playback of 3D audio in VR usually directly use binaural reconstruction methods. At present, more 3D audio reconstruction techniques have actually been applied in VR, mainly including human-based binaural audio system reconstruction analysis. Technology and audio reconstruction of related transfer functions. This paper clearly proposes a precise network deployment design algorithm based on mobile wireless audio signal sensors based on network virtualization capabilities, and clearly proposes the basic concept of "relay node clusters", using the current ubiquitous relays in Internet audio networks The network phenomenon of the clusters of nodes connecting to each other builds up such a network path from the source relay node to the virtualized audio sensor node. A comparative analysis experiment with similar types of algorithms shows that the characteristic of this algorithm is that it has obvious advantages in the average position movement of nodes and the energy expenditure of each node in the network. In addition, this article also applies sensor networks to the teaching of English MOOCs, conducts preliminary investigations on the learning problems of English MOOCs, and establishes learning goals, selects learning resources, learning modes, and interactive communication platforms based on the results of the questionnaire survey. , Design the classroom teaching process. According to the mobile sensor network, MOOC resources and "flipped classroom" are integrated with each other to implement a hybrid classroom teaching. Mobile sensor networks provide new ideas for virtual audio design and English MOOC teaching.
A clinical prediction model for testicular cancer prognosis: from the SEER study
Authors: Zhao Yicheng 
Published: April 2023

Abstract
Background: The influencing factors on the prognosis of patients with testicular cancer (TC) remains unclear. We aimed to explore the clinical influencing factors of overall survival (OS) and cancer-specific survival (CSS) of Testicular Cancer (TC) patients and to build the nomograms.
Methods: Within the Surveillance, Epidemiology, and End Results (SEER) database, 7718 TC patients diagnosed between 2004 and 2018 were included and their clinical data were assessed. The data were randomly divided into training and validation cohorts in a ratio of 7:3 to construct the prediction models. Prognosis information including 3-, 5-, and 10-year OS and CSS rates were recorded. In this study, the Kaplan-Meier method was used to draw the survival curve and variables with P<0.05 in the univariate Cox proportional hazard regression model were included in the multivariate Cox proportional hazard regression model for analysis. The relative risk of death was described with the hazard ratio (HR) and the 95% confidence interval (CI). The differentiation of the model was evaluated by using ROC and calculating the AUC values at different time points. Based on the data of the prediction set, the Bootstrapping method was adopted, repeated sampling 1000 times, and calibration curves were drawn to evaluate the fit degree of the model. Based on the results of the Cox proportional risk regression model, we constructed and internally validated an applicable nomogram for predicting 3-year, 5-year and 10-year survival in patients with testicular cancer.
Results: A total of 7718 patients were included in the prognostic model. In the multivariate Cox regression model, older age at diagnosis, without surgery, regional lymph node involvement (N1, N2, N3 and NX), with chemotherapy and larger tumor size were independent predictors of poor prognosis factors for OS and CSS in TC patients. The C-indexes were 0.75 (95% confidence interval [CI]: 0.72- 0.78) for OS and 0.82 (95% CI: 0.79- 0.85) for CSS, indicating that the prognosis of testicular cancer patients had a good predictive effect. Based on the nomogram, in the verification group, the AUC values of the 3-, 5-, and 10-year OS were 0.799, 0.757; 0.725, and 0.827, 0.823, and 0.825 for 3, 5, and 10- years CSS, respectively. The differences in the OS and CSS between the real observation and the forecast were quite constant according to the calibration curves. The models were validated in the validation cohort, which also demonstrated the models had good reliability for prognostication.
Conclusions: Clinical factors including age at diagnosis, surgery conditions, N Stage, chemotherapy conditions and tumor size were good predictors for OS and CSS in TC. Our predictive nomogram may play an important role in predicting 3-, 5-, and 10-year outcomes in patients with TC.
Association between breakfast consumption and handgrip strength：A systematic review and meta-analysis of cross- sectional study
Authors: Ren Zhongyu , Zhang Xiaoping , Liu Shuai , Cao Bing , Wang Hejin 
Published: April 2023

Abstract
Background In the past decade, several studies examined the association between breakfast consumption and handgrip strength, there are conflicting evidences on the association between breakfast consumption and handgrip strength. Therefore, this meta-analysis aimed to further identify the association between breakfast consumption and handgrip strength.Methods Original research studies involving breakfast consumption and handgrip strength from database inception to September 15, 2021 were selected from Web of Science, Pubmed, Medline and the China National Knowledge Infrastructure (CNKI). A random effects model was used to calculate the standardized mean difference (SMD) with 95% confidence intervals (CIs) of handgrip strength for the highest versus lowest category of breakfast consumption.Results After evaluation of titles and abstracts, 7 full-text articles met the inclusion criteria and 4 of them were included in meta-analysis. All studies were considered having higher quality of publications. An positive and insignificant association between breakfast consumption (lowest vs. highest) with handgrip strength was shown (Hedges' g = 0.09; 95% CI: -0.05 to 0.24; P = 0.21). Further analyses found a significant association between regular breakfast consumption and higher handgrip strength in female (Hedges' g = 0.20; 95% CI: 0.01 to 0.39; P = 0.03) but not in male (Hedges' g = 0.06; 95% CI: -0.13 to 0.24; P = 0.52). The heterogeneity in the results of this meta-analysis could be partly explained by adjustment for significant confounding factors and the measuring tools of handgrip strength. Results from subgroup analyses suggested that stratified analysis revealed a significant association between regular breakfast consumption and higher handgrip strength (Hedges' g = 0.15; 95% CI: 0.06 to 0.24; P < 0.01) in studies adjusting significant confounding factors, and the association between regular breakfast consumption and higher handgrip strength are significant (Hedges' g = 0.11; CI: 0.07 to 0.15; P < 0.01) when handgrip strength was measured by TKK 5401.Conclusion This meta-analysis indicated that regular breakfast consumption is positively associated with higher handgrip strength.
Feasibility, Reproducibility, and Prognostic Value of the Fully Automated Measurement of Left Ventricular Longitudinal Strain in Heart Transplant Recipients
Authors: Cai Yu , Wu Chun , Zhu Shuangshuang , Sun Wei , Zhang Yanting , Xie Yuji , Tan Yuting , Yan Xiaojun , Huang Lei , Zhang Yichan , Zhang Yiwei , Li Yuman , Yang Yali , Wang Jing , Sun Zhenxing , Zhang Li , Xie Mingxing 
Published: April 2023

Abstract
Aims Left ventricular longitudinal strain (LVGLS) is a robust parameter to predict adverse events of heart transplanted (HTx) patients. However, measuring LVGLS is time consuming and operator-dependent. Thus, we investigated whether automated strain software applied to measure LVGLS possess the feasibility, reproducibility and prognostic values in HTx patients.Methods 286 heart-transplanted patients who had comprehensive echocardiography was included. LVGLS was obtained from the same apical images by three different methods: fully automated LVGLS(Auto-Strain), semiautomated LVGLS (automated with manual editing) and manual LVGLS. Patients were followed up and primary composite end point (defined as all-cause death and rejection) was recorded.Results Fully automated measurements were feasible in 277subjects (96.8%). Analysis time for automated LVGLS (27.7 ± 2.8 s/patients) and semiautomated LVGLS (237.4 ± 41.0 s/patients) were shorter than manual LVGLS (440.4 ± 65 s/patients). Semiautomated LVGLS had a stronger correlation with manual LVGLS than automated LVGLS (r = 0.854 vs 0.654. P < 0.001), and there were smaller disagreements between Semiautomated LVGLS and manual LVGLS (bias:0.79, LOA:2.78) than automated LVGLS and manual LVGLS (bias:2.72, LOA:3.98). During a median follow-up of 51 months [35.0-66.5], 35 patients experienced end point events. Automated LVGLS can detect abnormal systolic function and predict adverse events of HTx patients, while the detecting and predicting ability of semiautomated LVGLS is greater.Conclusions Fully automated LVGLS could provide rapid and reproducible assessment of HTx patients’ graft function, but semiautomated LVGLS is superior to automated LVGLS in detecting abnormal systolic function and predicting adverse events, making it possible applying automated software in clinical routine.
Flood Reduction and Prevention Possibilities in the Flood Plains: A Case study of the Varuna River Basin in the Flood Plain of the Ganga River, Uttar Pradesh, India
Authors: Mishra Mallikarjun , Raju K. N. Prudhvi 
Published: April 2023

Abstract
Floods are a recurring phenomenon in the floodplain region of the Ganga River largely caused by several floodplain tributaries. One such tributary of the Ganga in its floodplain is the 225kmlong monsoon-fed Varuna River. Using high-resolution Google earth satellite images, 662 tals(local word for large natural ponds),and 15383 other smaller ponds/tanks(natural andman-made),were identified and delineated. The tals and ponds/tanksoccupy 430 km2 and 93 km2 respectively,within the 3141 km2area of the Varuna River basin. Based on the areas and approximate water depths that were averaged from field measurements at selected tals and ponds/tanks, the total water-holding capacity of all these water bodies is estimated to be as much as 57% (1140 million cubic metres) of the total surface water runoff of the basin.In spite of such a large water-holding capacity within these tals and ponds/tanks, floods are still an almost annual phenomenon in the Varuna basin because (i) water is not allowed to accumulate in the talsand (ii)the ponds/tanks haveshrunk and/or silted up,reducing their volume. Deepeningby desiltingof tals and ponds/tanks can be taken upby engaging the locallabourersthrough the government-funded rural employment guarantee schemes. The majority of the village tals and ponds/tanks can be used for pisciculturein order to generatedevelopment funds.
Postoperative cardiothoracic ratio on the first postoperative day is a predictor of postoperative pleural effusion drainage following hepatectomy
Authors: Sakamoto Akimasa , Sakamoto Katsunori , Shine Mikiya , Uraoka Mio , Nagaoka Tomoyuki , Honjo Masahiko , Tamura Kei , Funamizu Naotake , Ogawa Kohei , Takada Yasutsugu 
Published: April 2023

Abstract
Purpose Although several preoperative risk factors for postoperative pleural effusion (POPE) after hepatectomy have been reported, few postoperative predictors have been investigated. We aimed to examine risk factors for clinically relevant POPE (CR-POPE) and whether cardiothoracic ratio (CTR) could be a predictive factor.Methods Participants in this retrospective investigation comprised 382 patients who underwent hepatectomy between January 2012 and December 2021. Perioperative characteristics that were considered potential risk factors for CR-POPE were evaluated. CR-POPE was defined as having undergone thoracentesis or thoracic drain placement.Results Patients were divided into a CR-POPE group (n = 38; 10.0%) and a non-CR-POPE group (n = 344; 90.0%). The CR-POPE group showed significantly higher intraoperative infusion volume (P < 0.001) and lower intraoperative urine volume (P = 0.015). In multivariate analysis, abdominal incision with a reversed L-shape or inverted T-shape (odds ratio [OR] = 3.07, P = 0.023], estimated blood loss > 772 g (OR = 2.71, P = 0.049), diaphragm incision (OR = 8.31, P = 0.008), major postoperative complications excluding CR-POPE (OR = 7.99, P < 0.001), intraoperative infusion volume per body weight > 80 mL/kg (OR = 4.80, P = 0.007) and CTR on postoperative day (POD)1 > 59.0% (OR = 4.34, P = 0.001) were all independently associated with occurrence of POPE.Conclusion We clarified risk factors for CR-POPE following hepatectomy. The occurrence of CR-POPE might be predictable from the CTR on POD1.
Continuous analgesia with intercostal catheterization under the thoracoscopy
Authors: Wang Yifei , Sun Qi , Huang Yiling , Yang Qinghua , Chen Rong , Zhang Xianwei , Zhao Xuewei , Wang Mingdong 
Published: April 2023

Abstract
Background
There are few studies on continuous intercostal nerve block after single operation hole thoracoscopic surgery, i.e., two-port thoracoscopic surgery.
Objective
To evaluate the analgesic effect of continuous intercostal nerve block after thoracoscopic surgery.
Methods
A total of 80 patients who underwent single operation hole thoracoscopic surgery in our hospital between September 2020 and June 2021 were enrolled and divided into two groups. Based on basic analgesia, an intercostal catheter was placed during the operation for continuous intercostal block analgesia after the operation in the experimental group (Group A, n = 40). The control group (Group B, n = 40) was treated with sufentanil intravenous analgesia after surgery, which is namely “basic analgesia”. The postoperative pain scores, restlessness during the recovery period, effect on reducing opioid use, postoperative chest complications, patient satisfaction, etc., were compared between the two groups.
Results
The pain scores of patients in group A were significantly lower compared to those in group B at 12, 24, 36, and 48 hours after surgery (3.325 ± 1.163 vs. 4.550 ± 1.176, 2.650 ± 1.001 vs. 4.000 ± 1.038, 2.325 ± 0.917 vs. 3.700 ± 0.966, and 1.775 ± 1.050 vs. 3.150 ± 1.075, p ＜0.001, respectively). Sufentanil consumption in group A was significantly lower than in group B at 48 hours after surgery (98.625 ± 4.158 vs. 106.000 ± 7.228, p ＜0.001).
Conclusion
Multimodal analgesia is ideal for early pain control after thoracotomy. A continuous intercostal nerve block can effectively reduce postoperative pain in patients.
Dynamics of a predator-prey model in spatially heterogeneous environments
Authors: Wang Qi 
Published: April 2023

Abstract
In this paper, we consider a diffusive predator-prey model in spatially heterogeneous environments. We study the classification of the stability of the semi-trivial steady states according to parameters b, c and the dispersal rates of the prey and predator. Our work is a further study of [12].
Mathematics Subject Classification (2010): 35B35, 35K57, 35Q92, 92D25
Characterization of the Bernoulli polynomials via the Raabe functional equation
Authors: Farhi Bakir 
Published: April 2023

Abstract
The purpose of the present paper is to show that in certain classes of real (or complex) functions, the Bernoulli polynomials are essentially the only ones satisfying the Raabe functional equation. For the class of the real 1-periodic functions which are expandable as Fourier series, we point out new solutions of the Raabe functional equation, not relating to the Bernoulli polynomials. Furthermore, we will give for the considered classes various proofs, making the mathematical content of the paper quite rich.
Freedom From Infection (FFI): A paradigm shift towards evidence-based decision-making for malaria elimination.
Authors: Nelli Luca , Surendra Henry , Byrne Isabel , Ahmad Riris , Arisanti Risalia , Lesmanawati Dyah , Elyazar Iqbal , Dumont Elin , Drakeley Chris , Wu Lindsey , Matthiopoulos Jason , Stresman Gillian 
Published: April 2023

Abstract

Eliminating malaria locally requires a surveillance system with high sensitivity and specificity to detect its presence without ambiguity. Traditionally, the absence of locally acquired cases for three consecutive years is used to estimate the probability of elimination. However, proving the absence of infection using routine health data is challenging as even one missed infection can lead to incorrect inferences. This could result in premature termination of control efforts and resurgences. To address this, we propose an innovative method for probabilistically demonstrating the absence of malaria. Using spatio-temporally extensive but imperfect reports of malaria, we developed a novel statistical framework to model both the state process (malaria transmission in the population) and the observation process (cases detected by the health system). Our state-space model provides a robust estimate of the surveillance system's sensitivity and the corresponding probability of elimination (PFree). It can also quantify challenging parameters related to malaria transmission and surveillance sensitivity. Our study highlights the effectiveness of data-driven tools in decision-making for malaria and suggests a reassessment of the conventional method for confirming elimination.
Risk of eating disorders and its association with psychological factors, body mass index, and physical activity in Mexican university students
Authors: González-Alvarado Yazmín , Unikel-Santoncini Claudia , Saucedo-Molina Teresita de Jesús 
Published: April 2023

Abstract

BackgroundDisordered eating behaviors are factors associated with the risk of developing eating disorders, yet cause biological, psychological, and social malfunction and its prevalence has been identified in university students of both sexes. The aim of the current study was to determine the distribution of the risk of developing an eating disorder and its association with psychological variables such as, thin-ideal internalization, body dissatisfaction, negative affect, drive for muscularity, as well as with body mass index (BMI) and physical activity in a non-probabilistic sample of Mexican university students. An additional objective was to evaluate the risk association with all of these variables by sex.MethodsA cross-sectional study was carried out between ending January and the beginning of May 2021 on a non-probabilistic sample of 395 students (65% females) aged to 18-29. Each one of the variables was assessed with previously validated questionnaires.ResultsThe risk of developing an eating disorder (moderate and high) was 37.3% for females and 32.6% for males. With significant differences, drive for muscularity in males registered 21% vs. 7.8% in females. The risk analysis in females showed an association with thin-ideal internalization, negative affect, body dissatisfaction, BMI, and physical activity. In males, risk analysis revealed an association with drive for muscularity and negative affect. After the logistic regression analysis, internalization, BMI, and low level of physical activity showed an association in females, and the association with drive for muscularity and BMI was maintained in males.ConclusionsAlthough eating disorder risk and associated factors have typically been a subject of study in adolescents, these findings show that they also have a significant presence in both male and female university students, and that they should be considered in future preventive interventions.
Assessing resilience at different scales: from single assets to complex systems
Authors: Fuggini Clemente , Solari Celina , De Stefano Rita , Bolletta Fabio , De Maio Florencia Victoria 
Published: April 2023

Abstract

Nowadays, Critical Infrastructure and Systems are getting more and more interconnected, while facing increasing and more intensive hazards: from man-made to natural ones, including those exacerbated by effects of the climate change. The demand for their robustness and resiliency against all these threats is finding ground to organizations or states’ ambitions, implementations, and policies. Moreover, their distributed network spanning from local areas to cities, from regions to cross-country extension, make them a target for malicious actions aimed to damage or even disrupt their critical supplied and therefore the availability of the service they deliver. The paper focuses on a review from an engineering perspective of past efforts (namely those related to the H2020 SecureGas project) and provides evidence of application cases where the network/system dimension of the critical infrastructure is a key point to be considered and to be safeguarded. Finally, an outlook on future perspectives and potentials in the application of resilience at local, urban, and territorial/national level is described, with a with on incoming and emerging threats at local and global level.