bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Influence of Input Feature Space on CNN‐Based Geomorphic Feature Extraction From Digital Terrain Data
Authors: Maxwell Aaron E. , Odom William E. , Shobe Charles M. , Doctor Daniel H. , Bester Michelle S. , Ore Tobi 
Published: May 2023

AbstractMany studies of Earth surface processes and landscape evolution rely on having accurate and extensive data sets of surficial geologic units and landforms. Automated extraction of geomorphic features using deep learning provides an objective way to consistently map landforms over large spatial extents. However, there is no consensus on the optimal input feature space for such analyses. We explore the impact of input feature space for extracting geomorphic features from land surface parameters (LSPs) derived from digital terrain models (DTMs) using convolutional neural network (CNN)‐based semantic segmentation deep learning. We compare four input feature space configurations: (a) a three‐layer composite consisting of a topographic position index (TPI) calculated using a 50 m radius circular window, square root of topographic slope, and TPI calculated using an annulus with a 2 m inner radius and 10 m outer radius, (b) a single illuminating position hillshade, (c) a multidirectional hillshade, and (d) a slopeshade. We test each feature space input using three deep learning algorithms and four use cases: two with natural features and two with anthropogenic features. The three‐layer composite generally provided lower overall losses for the training samples, a higher F1‐score for the withheld validation data, and better performance for generalizing to withheld testing data from a new geographic extent. Results suggest that CNN‐based deep learning for mapping geomorphic features or landforms from LSPs is sensitive to input feature space. Given the large number of LSPs that can be derived from DTM data and the variety of geomorphic mapping tasks that can be undertaken using CNN‐based methods, we argue that additional research focused on feature space considerations is needed and suggest future research directions. We also suggest that the three‐layer composite implemented here can offer better performance in comparison to using hillshades or other common terrain visualization surfaces and is, thus, worth considering for different mapping and feature extraction tasks.
Anthropogenic Bromoform at the Extratropical Tropopause
Authors: Jia Yue , Hahn Josefine , Quack Birgit , Jones Edward , Brehon Meghan , Tegtmeier Susann 
Published: May 2023

AbstractBromoform (CHBr3) contributes to stratospheric ozone depletion but is not regulated under the Montreal Protocol due to its short lifetime and large natural sources. Here, we show that anthropogenic sources contribute significantly to the amount of CHBr3 transported into the Northern Hemisphere (NH) extratropical stratosphere. We present a new CHBr3 emission inventory comprised of natural and anthropogenic sources, with the latter estimated from ship ballast, power plant cooling and desalination plant brine water. Including anthropogenic sources in the new inventory increases CHBr3 emissions by up to 31.5% globally and 70.5% in the NH. In consequence, atmospheric CHBr3 is also significantly higher, especially over the NH extratropics during boreal winter. Here anthropogenic sources enhance bromine at the tropopause by 0.9 ppt Br, thus doubling natural CHBr3 abundances. For some latitudes, tropopause bromine increases by 2.4 ppt Br suggesting significant contributions of anthropogenic CHBr3 to the NH lowermost stratosphere.
Integrating Psychology Into Pediatric Audiology/Otolaryngology Clinics: Gaps and a Model of Care
Authors: Hoffman Michael F. , Landsman Rachel A. , Fasano-McCarron Matthew E. , Schoffstall Sarah J. , Witkin Gregory A. , Parkes William J. 
Published: May 2023

Objective: This manuscript reviews what is known about psychopathology and neurodevelopmental outcomes in deaf/hard of hearing (DHH) children, identifies current research and clinical gaps, and presents a model of care for integrating psychology into pediatric otolaryngology/audiology clinics that serve DHH patients and their families. Methods: This manuscript uses a literature review and clinical reflection/peer collaboration to develop a model of integrated psychological services for pediatric psychologists in otolaryngology/audiology clinics. Results: DHH children and their families often require support beyond the traditional focus on speech/language delays. Additional concerns include increased rates of co-occurring psychological conditions (e.g., anxiety, depression), early and potentially persistent changes in neurological/neurobehavioral functioning with or without atypical language development, high levels of caregiver-reported distress, and additional medical complexities. Conclusions: Traditionally, models of multidisciplinary care for DHH children have centered on a triad of otolaryngologists, audiologists, and speech/language pathologists. However, the reviewed data clearly show these models leave numerous unmet needs that psychologists can help address. Incorporating psychologists into pediatric otolaryngology/audiology clinic settings that serve DHH patients is an essential ingredient in high-quality care that helps meet the needs of the “whole child.” Implications for Impact Statement DHH children and families are an at-risk and underserved group that frequently interacts with the pediatric health care system. This paper presents the first model of care for integrating psychologists into the medical/audiological settings that serve these patients.
p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response
Authors: Salemme Vincenzo , Vedelago Mauro , Sarcinella Alessandro , Moietta Federico , Piccolantonio Alessio , Moiso Enrico , Centonze Giorgia , Manco Marta , Guala Andrea , Lamolinara Alessia , Angelini Costanza , Morellato Alessandro , Natalini Dora , Calogero Raffaele , Incarnato Danny , Oliviero Salvatore , Conti Laura , Iezzi Manuela , Tosoni Daniela , Bertalot Giovanni , Freddi Stefano , Tucci Francesco A. , De Sanctis Francesco , Frusteri Cristina , Ugel Stefano , Bronte Vincenzo , Cavallo Federica , Provero Paolo , Gai Marta , Taverna Daniela , Turco Emilia , Pece Salvatore , Defilippi Paola 
Published: May 2023

AbstractThe p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and systemic tumor-extrinsic events that eventually result in inhibition of the polymorphonuclear myeloid-derived suppressor cell function in creating an immunosuppressive tumor-promoting environment in the primary tumor, and premetastatic niches at distant sites. Integrative transcriptomic and preclinical studies unravel that p140Cap controls an epistatic axis where, through the upstream inhibition of β-Catenin, it restricts tumorigenicity and self-renewal of tumor-initiating cells limiting the release of the inflammatory cytokine G-CSF, required for polymorphonuclear myeloid-derived suppressor cells to exert their local and systemic tumor conducive function. Mechanistically, p140Cap inhibition of β-Catenin depends on its ability to localize in and stabilize the β-Catenin destruction complex, promoting enhanced β-Catenin inactivation. Clinical studies in women show that low p140Cap expression correlates with reduced presence of tumor-infiltrating lymphocytes and more aggressive tumor types in a large cohort of real-life female breast cancer patients, highlighting the potential of p140Cap as a biomarker for therapeutic intervention targeting the β-Catenin/ Tumor-initiating cells /G-CSF/ polymorphonuclear myeloid-derived suppressor cell axis to restore an efficient anti-tumor immune response.
Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1
Authors: Hori Shogo , Tateyama Michihiro , Shirai Tsuyoshi , Kubo Yoshihiro , Saitoh Osamu 
Published: May 2023

AbstractTRPV1 plays an important role in the thermosensory system; however, the mechanism controlling its heat activation property is not well understood. Here, we determine the heat activation properties of TRPV1 cloned from tailed amphibians, which prefer cooler environments, finding the threshold temperatures were approximately 10 °C lower compared with rat TRPV1 (rTRPV1). We find that two amino acid residues (Gln, Leu/Val) in the Ankyrin Repeat 1 (ANK1) region of the N-terminal domain are conserved among tailed amphibians and different from those (Arg, Lys) in rTRPV1. We observe the activation by heat in all urodelan TRPV1s is markedly elevated by substitution of these two amino acids. Conversely, reciprocal substitutions of rTRPV1 apparently lowers the high threshold temperature. Our studies demonstrate that tailed amphibians express TRPV1 with a reduced heat-activation threshold by substitution of two amino acid residues in the ANK1 region that likely contribute to cool-habitat selection.
Spectro-spatial features in distributed human intracranial activity proactively encode peripheral metabolic activity
Authors: Huang Yuhao , Wang Jeffrey B. , Parker Jonathon J. , Shivacharan Rajat , Lal Rayhan A. , Halpern Casey H. 
Published: May 2023

AbstractMounting evidence demonstrates that the central nervous system (CNS) orchestrates glucose homeostasis by sensing glucose and modulating peripheral metabolism. Glucose responsive neuronal populations have been identified in the hypothalamus and several corticolimbic regions. However, how these CNS gluco-regulatory regions modulate peripheral glucose levels is not well understood. To better understand this process, we simultaneously measured interstitial glucose concentrations and local field potentials in 3 human subjects from cortical and subcortical regions, including the hypothalamus in one subject. Correlations between high frequency activity (HFA, 70–170 Hz) and peripheral glucose levels are found across multiple brain regions, notably in the hypothalamus, with correlation magnitude modulated by sleep-wake cycles, circadian coupling, and hypothalamic connectivity. Correlations are further present between non-circadian (ultradian) HFA and glucose levels which are higher during awake periods. Spectro-spatial features of neural activity enable decoding of peripheral glucose levels both in the present and up to hours in the future. Our findings demonstrate proactive encoding of homeostatic glucose dynamics by the CNS.
Emission enhancement of erbium in a reverse nanofocusing waveguide
Authors: Güsken Nicholas A. , Fu Ming , Zapf Maximilian , Nielsen Michael P. , Dichtl Paul , Röder Robert , Clark Alex S. , Maier Stefan A. , Ronning Carsten , Oulton Rupert F. 
Published: May 2023

AbstractSince Purcell’s seminal report 75 years ago, electromagnetic resonators have been used to control light-matter interactions to make brighter radiation sources and unleash unprecedented control over quantum states of light and matter. Indeed, optical resonators such as microcavities and plasmonic antennas offer excellent control but only over a limited spectral range. Strategies to mutually tune and match emission and resonator frequency are often required, which is intricate and precludes the possibility of enhancing multiple transitions simultaneously. In this letter, we report a strong radiative emission rate enhancement of Er3+-ions across the telecommunications C-band in a single plasmonic waveguide based on the Purcell effect. Our gap waveguide uses a reverse nanofocusing approach to efficiently enhance, extract and guide emission from the nanoscale to a photonic waveguide while keeping plasmonic losses at a minimum. Remarkably, the large and broadband Purcell enhancement allows us to resolve Stark-split electric dipole transitions, which are typically only observed under cryogenic conditions. Simultaneous radiative emission enhancement of multiple quantum states is of great interest for photonic quantum networks and on-chip data communications.
Molecular basis of the TRAP complex function in ER protein biogenesis
Authors: Jaskolowski Mateusz , Jomaa Ahmad , Gamerdinger Martin , Shrestha Sandeep , Leibundgut Marc , Deuerling Elke , Ban Nenad 
Published: May 2023

AbstractThe translocon-associated protein (TRAP) complex resides in the endoplasmic reticulum (ER) membrane and interacts with the Sec translocon and the ribosome to facilitate biogenesis of secretory and membrane proteins. TRAP plays a key role in the secretion of many hormones, including insulin. Here we reveal the molecular architecture of the mammalian TRAP complex and how it engages the translating ribosome associated with Sec61 translocon on the ER membrane. The TRAP complex is anchored to the ribosome via a long tether and its position is further stabilized by a finger-like loop. This positions a cradle-like lumenal domain of TRAP below the translocon for interactions with translocated nascent chains. Our structure-guided TRAP mutations in Caenorhabditis elegans lead to growth deficits associated with increased ER stress and defects in protein hormone secretion. These findings elucidate the molecular basis of the TRAP complex in the biogenesis and translocation of proteins at the ER.
Running Energy Reserve Index (RERI) as a new model for assessment and prediction of world, elite, sub-elite, and collegiate running performances
Authors: Balasekaran Govindasamy , Loh Mun Keong , Boey Peggy , Ng Yew Cheo 
Published: May 2023

AbstractThe purpose of this study was to utilize the Running Energy Reserve Index (RERI) model and two-trial procedure to predict all-out athletic performances. Twenty-nine trained athletes tested for differences between RERIE and RERIspd (hypothesis 1). Six sprint trained (ST), six middle distance (MD), and six endurance trained (ET) athletes were selected to test for differences in the value of the constant. The prediction of all-out run performances using the RERI model (hypothesis 2) and two treadmill trials procedure (hypothesis 3) were tested on eighteen trained athletes. Lastly, three trained athletes were utilized to predict all-out running performances utilizing two track trials equation (hypothesis 3). RERIE and RERIspd were significantly different between ST, MD, and ET athletes. The RERIE model with a fixed cE value of 0.0185 s−1 predicted all-out running performances to within an average of 2.39 ± 2.04% (R2 = 0.99, nT = 252) for all athletes, with treadmill trials to within an average of 2.26 ± 1.89% (R2 = 0.99, nT = 203) and track trials to within an average of 2.95 ± 2.51% (R2 = 0.99, nT = 49). The two trials equations predicted all-out track performances to within errors of 2.43%. The RERI model may be accurate in determining running performances of 200 m and 5000 m, and treadmill performances ranging between 5 and 1340 s with a high level of accuracy. In addition, the two-trial procedure can be used to determine short and middle distance running performances of athletes and world-class runners.
Correlation of index finger length to vertical dimensions of occlusion for edentulous patients and their satisfaction: a randomized controlled trial
Authors: Khan Shujah Adil , Raza Kazmi Syed Murtaza , Ahmed Shahbaz , Hani Ume , Choudhry Ziaullah , Sukkurwala Adnan 
Published: May 2023

AbstractThe prevalence of edentulism is pandemic and people resort to complete dentures for the restoration of missing teeth and esthetics. However, the determination of the correct occlusal vertical dimensions (OVD) constitutes to play an important role in overall patient satisfaction. The objective of this study was to apply anthropometric methods to correlate the length of index finger (2D) to measure the OVD from base of the nose to the base of the chin (Sn–Me) and to assess satisfaction by comparing both the methods. A total of 80 edentulous patients were randomized and controlled for this trial into experimental and control groups. A correlation was found between Sn–Me and finger measurements, dentures’ satisfaction was assessed after a 1-week follow-up and marked according to the Visual Analog Scale. Our findings established that finger measurements are greater among males, and in both genders, positive, and statistically significant correlations exist between the facial and finger length measurements. Moreover, 97.0% patients from experimental group were satisfied with the use of complete dentures through the new anthropometric method. Hence measuring the length of index finger can be an adjunct method for the restoration of OVD and is a relatively time-effective and simple method with a satisfactory follow-up.Trial registration: ID: NCT05153213 (https://clinicaltrials.gov/ct2/show/NCT05153213).
Peripheral targets attenuate miniature eye movements during fixation
Authors: Watamaniuk Scott N. J. , Badler Jeremy B. , Heinen Stephen J. 
Published: May 2023

AbstractFixating a small dot is a universal technique for stabilizing gaze in vision and eye movement research, and for clinical imaging of normal and diseased retinae. During fixation, microsaccades and drifts occur that presumably benefit vision, yet microsaccades compromise image stability and usurp task attention. Previous work suggested that microsaccades and smooth pursuit catch-up saccades are controlled by similar mechanisms. This, and other previous work showing fewer catch-up saccades during smooth pursuit of peripheral targets suggested that a peripheral target might similarly mitigate microsaccades. Here, human observers fixated one of three stimuli: a small central dot, the center of a peripheral, circular array of small dots, or a central/peripheral stimulus created by combining the two. The microsaccade rate was significantly lower with the peripheral array than with the dot. However, inserting the dot into the array increased the microsaccade rate to single-dot levels. Drift speed also decreased with the peripheral array, both with and without the central dot. Eye position variability was higher with the array than with the composite stimulus. The results suggest that analogous to the foveal pursuit, foveating a stationary target engages the saccadic system likely compromising retinal-image stability. In contrast, fixating a peripheral stimulus improves stability, thereby affording better retinal imaging and releasing attention for experimental tasks.
Energy transfer across magnetopause under dawn–dusk IMFs
Authors: Zhang H. X. , Lu J. Y. , Wang M. 
Published: May 2023

AbstractA parametric study on the energy transfer of the solar wind across the magnetopause entering the magnetosphere is conducted using a global magnetohydrodynamic numerical simulation. The characteristics of the mechanical and electromagnetic energy distribution under the dawn–dusk interplanetary magnetic fields (IMFs) are investigated by analyzing magnetic reconnection and viscous effect, and compared with the radial and north–south IMFs. It is shown that (1) the interactions at the magnetopause and the transfer of energy across this boundary move in relation to the IMF orientation. (2) For the duskward IMF, the mechanical energy flow clearly enters the equatorial and low-latitude regions on the dayside, and the electromagnetic energy flow has a small inflow on the equatorial and low latitudes of the dayside. A significant energy inflow appears on the dawn side in the northern hemisphere and the dusk side in the southern hemisphere near the polar cusp. (3) The energy distribution characteristics across the magnetopause under dawn–dusk IMFs are mirror symmetric about the $$Y=0$$

Y
=
0

plane. (4) For a magnetic field of 5 nT, the electromagnetic energy input under the dawn–dusk IMFs is twice as large as the mechanical energy and the electromagnetic energy under the radial IMF, which is five times as large as the electromagnetic energy during the pure northward IMF, but only half as large as the electromagnetic energy under the pure southward IMF. The mechanical energy input under dawn–dusk IMFs has the same magnitude as that under radial and north–south IMFs. The magnitude of the energy transfer rate for the dawn IMF and dusk IMF (about 3.5%) is between 1.71% for the northward IMF and 4.95% for the southward IMF, but higher than 2.22% for the radial IMF. The Akasofu-type energy-coupling formula, $$\varepsilon$$
ε
, underestimates the energy input from the solar wind under $$B_{y}$$

B
y

dominated IMF.
Biosynthesis, characterization and anthelmintic activity of silver nanoparticles of Clerodendrum infortunatum isolate
Authors: Majumdar Rima , Kar Pradip Kumar 
Published: May 2023

AbstractOver the past few decades, the green synthesis of nanoparticles has gained importance for their therapeutic efficacy and eco-friendly nature. Integrating green chemistry principles into multidisciplinary nanoscience research has paved the way for developing environmentally benign and sustainable methods for synthesizing gold and silver nanoparticles. In the present study, the flowers obtained from Clerodendrum infortunatum (L.), belonging to the family Verbenaceae, have been used for biosynthesizing silver nanoparticles (AgNPs) to evaluate the anthelmintic potential. UV–Vis spectroscopy, XRD, FTIR, SEM and TEM analyses were performed to ascertain the formation of AgNPs. Clerodendrum-derived AgNP (CLE-AgNP) has significantly affected the normal physiological functions of the poultry parasite Raillietina spp., a menace to the livestock industry. Our study manifests that CLE-AgNPs cause considerable distortion of the surface tegument of this cestode parasite leading to changes in the host-parasite interface. The histochemical localization studies of the tegument-associated enzymes viz. AcPase, AlkPase, ATPase and 5’-Nu, exposed to the drug, showed a substantial activity decline, thus establishing the anthelmintic potential of the CLE-AgNPs.
Study on seismic vulnerability analysis of the interaction system between saturated soft soil and subway station structures
Authors: Cheng Xuelei , Li Qiqi , Hai Ran , He Xianfeng 
Published: May 2023

AbstractThe seismic vulnerability of interaction system of saturated soft soil and subway station structures was explored in this paper. The coupled nonlinear numerical models of interaction system were established using the u–p formulation of Biot′s theory to describe the saturated two-phase media. A refined finite element model of interaction system was developed to study its nonlinear seismic responses and seismic hazard mechanism. In this study, the multi-yield elastoplastic constitutive model was adopted for the soil, while a fiber section elastoplastic constitutive model was used for the structure. The seismic response of the structure was calculated by inputting the artificial seismic wave obtained from the power spectrum-triangular series method. The maximum inter-story drift angle was taken as a structural performance parameter for the subway station structure. The structural demand cloud was obtained under random ground motion sequences. Based on the probabilistic seismic demand model analysis method, the seismic vulnerability curve of the subway station structure was plotted, and the seismic vulnerability curve was analyzed as per the vulnerability of performance parameters. With the increase of soil strength, the vulnerability index of subway station structure under different peak acceleration ground motion decreased correspondingly. Based on the above vulnerability theory and analysis methods, it can be found from the above vulnerability theory and analysis methods that the subway station structure with established buried depth in saturated soft soil site exhibits a certain degree of safety and reliability, and can meet the seismic fortification goal of "no damage in small earthquakes, repairable in medium earthquakes and no collapse in large earthquakes". The results of vulnerability analysis are in line with the actual seismic survey, and the vulnerability analysis method proposed in this paper can be applied to the vulnerability analysis of underground structures on saturated soft soil foundation.