bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Flipped Classroom on EFL Learners' Self- Regulated Learning and Higher-Order Thinking Skills during the Covid19 Pandemic
Authors: Samadi Fatemeh , Jafarigohar Manoocher , Saeedi Masood , Ganji Mansoor , Khodabandeh Farzaneh 
Published: February 2023

Abstract

With the emergence of innovative online-based tools, new opportunities have emerged to improve the quality of language learning. The current study investigated the impact of flipped classroom on enhancing EFL learners’ cognitive and meta-cognitive competence. To this end, two groups of participants were selected for the two phases of the study and for comparing the impact of flipped classroom and conventional modes of instruction on enhancing EFL learners' self-regulated learning strategies and higher order thinking, two different sample sizes were needed. For the research questions, two groups of homogenous language learners were needed. The participants were selected from two private language institutes in Arak, Iran. To elicit the required data, multiple sources of data collection, Including Language proficiency test, the Self-Regulation Questionnaire, flipped classroom attitude questionnaire, Higher-order Thinking Skills Test, were used. The findings revealed that flipped classrooms significantly affect the learners' use of the subcategories of cognitive self-regulated learning strategies and also it can be concluded that the flipped classroom supports students in becoming self-directed learners. With regard to the impact of Flipped classroom on enhancing EFL learners’ higher-order thinking skills, it could be inferred that Flipped classrooms significantly affect the EFL learners’ use of evaluating, analyzing, and creating.
Novel Electrchemical Polymerization of Aminofluorenone and its Electrochemical behavior on Glassy Carbon Electrode
Authors: Asswadi F. A. , Azeem Magdi , qasem Jameel 
Published: February 2023

Abstract
Electropolymerization of 1-aminofluorenone, AFO, was prepared in CH2Cl2 and Bu4NClO4 solution as the electrolyte, via constant potential electrolysis. The redox behaviour of aminoflourenone(AFO) was investigated in methylene chloride as asolvent electrolyte medium using cyclic voltammetry (CV) of AFO polymer deposit on the electrode surface. Film formed through continuous cyclic voltammograms and the activity of film formed studied in aqueous solution. Factors affecting on the film formation by successive potential scans like potential limits, scan rate, number of cycles, monomer concentrations, the product was characterized by CV, Chronocoulometry techniques and FT-IR spectra, were examined in details to suppose the mechanism. To the best of knowledge, this is the first article on direct anodic oxidation of PAFO on saturated calomel electrode.
IoT herd monitoring: an opportunity facing the Iberian mountain challenges
Authors: Castro José , Castro Eduardo , Castro Marina 
Published: February 2023

Abstract
Pastoralism is essential for conserving the Iberian mountain landscapes, mainly through the itinerant grazing of herds of hundreds of goats and sheep. The new IoT technologies applied in this first approach are promising for a new paradigm of this management. We present the results obtained by GNSS devices on herds of goats and sheep in the central mountains of Portugal during the last year's grazing cycle, 2022. The locations of hundreds of daily grazing itineraries resulted in images showing the grazing pressure on the territory. Principal component analysis of these images highlights the primary role of the shepherd in selecting the journey zone and the animals remaining in preferred spots. The sequence of these components seems to analytically translate the articulation of scales inherent to herding processes previously described by several authors. It integrates scales from the broadest of the herder's initial determination of the grazing area to that of the herd's movement to the most detailed of each animal's food preferences at each site. The decisive role of these essential actors - the shepherds - in the management of Iberian rangelands, demonstrated by IoT technologies, should give confidence to policymakers to promote the value chain of extensive, territorially based small ruminant production over those intensive systems that take us away from the goals of sustainable development.
An Adaptive Agent-Based Model for Observing Smoking Cessation Patterns
Authors: Sordo Margarita , Phillips Andrew B. 
Published: February 2023

Abstract
Background
The complex effect of multiple influencing factors in the idiosyncrasies of how people frame a purpose, and the decisions and actions they carry out to reach a goal have a strong impact on repeated-occurrence behaviors, such as smoking cessation, where the perceived benefit of behavioral change may wane in response to difficulties or setbacks.
Purpose
We applied a modeling cycle methodology to implement a knowledge-based ABM to assess the impact of individual health preferences, and societal factors on modifiable behaviors to identify time-related opportunities for non-pharmaceutical interventions to sustain the desired behavioral changes.
Methods
We gathered and encoded information about patient beliefs, preferences, and societal factors as simple rules to roughly represent patient behaviors. Through ABM simulations we looked at idiosyncratic patterns stemming from the complex effect of multiple influencing factors.
Results
Marked smoking/non-smoking fluctuations of women vs. slower, steadier decline in smoking men highlight the complex effect of multiple influencing factors in the idiosyncrasies of how people frame a purpose, and the decisions and actions they carry out to reach a goal. Unintentional patterns of segregation underline the impact surrounding neighbors’ have on an agent’s behavior, blurring the line between individual motivation and collective influence, leading agents to align with the surrounding majority.
Conclusions
ABMs provide insights on the impact multi-factorial, dynamic individual behaviors, and societal factors have on repeated-occurrence modifiable behaviors, e.g., smoking cessation, and pinpoint opportune educational and motivational adjuvant interventions to counteract negative, more ingrained behaviors, and external factors to improve compliance and success.
Experiments Showing Incompleteness of Wave Theory of Light
Authors: Peng Hui 
Published: February 2023

Abstract

Young’s double slit experiments revived the wave theory of light. The standard interpretation is that the light behaves as waves before and after passing through the double slit. Feynman called the double slit experiment the only mystery in quantum mechanics. By placing a convex lens at different positions, we have shown: (1) Near the diaphragm, light behaves as photons and produces a non-interference pattern; near the screen, the photons produce an interference pattern; (2) The non-interference pattern evolves to the orthogonal interference pattern gradually in the same experiment; (3) The convex lens stops the further evolution. It is heuristic for study the nature of light by showing all of three different kinds of patterns on the screen simultaneously. For this purpose, in this article, we setup three paths. The light is divided into three portions, each portion propagates along one path. Then inserting three lenses to different Zones of different paths. Experiments show that two non-interference patterns and interference pattern simultaneously emerge on the same screen.
A healthier microbiome helps transgenic maize to defend herbicide toxicity
Authors: Dai Zhongmin , Chu Zhenjiang , Tao Mingzhu , Yu Zeyu , Tao Yimin , Feng Xuping , He Yong , Chen Huaihai , Xu Jianming 
Published: February 2023

Abstract
Background
Transgenic glyphosate-resistant maize has emerged as a way to expand the use of glyphosate for weed control. Studying the microbiome in transgenic plant and rhizosphere soil is vital for understanding the glyphosate-resistant mechanism and optimizing the transgenic design of crops.
Results
In our study, the transgenic modification did not affect the initial bacterial community in the leaf, stem, root of maize, but promoted a healthier microbiome in the rhizosphere soil. After glyphosate stimulation, the transgenic maize recruited more beneficial bacteria to regulate biocontrol, N fixation and P solubilization in both plant tissues and the rhizosphere soil than non-transgenic maize. Notably, the re-inoculation of differential Bacillus from transgenic maize into the leaf of glyphosate-sensitive maize resulted in an enhanced photosynthetic capacity in response to glyphosate, demonstrating the vital role of unique Bacillus for glyphosate resistance.
Conclusion
Our study provides important evidence of transgenic maize tolerance to herbicides from a microbial ecology perspective.
Light and bias-induced room temperature negative differential conductance in Ni-doped ZnO/p-Si Schottky photodiodes for quantum optical applications
Authors: Ocaya Richard O. , Orman Yusuf , Al-Sehemi Abdullah G. , Dere Aysegul , Al-Ghamdi Ahmed A. , Yakuphanoglu Fahrettin 
Published: February 2023

Abstract

We present evidence for the existence of bias and illumination-driven negative differential conductance (NDC) in Ni-doped aluminium/p-Silicon Schottky diodes. We suggest the Ridley–Watkins–Hilsum (RWH) mechanism as a possible explanation of the origin of this NDC. The NDC is dependent on the bias, doping level, and illumination. The dark currents do not show NDC regions, implying that it is a bias and illumination-dependent effect. We use surface plots to visually enhance the parametric trends in the output data. The resultant devices show excellent performance characteristics in both the photoconductive and the photovoltaic modes. The recently reported series resistance compensated method was applied to the I-V characteristics to extract the parameters of the diodes. The results show that Ni doping achieves NDC in reverse bias, between -1.5V to -0.5V, but only at certain doping levels in forward bias. The open circuit voltages of the devices in solar cell mode ranged from 0.03V to 0.6V.
NEW TRENDS IN ITALIAN LITERATURE: FROM ECOCRITICISM TO MIGRANT LITERATURE
Authors: Mihaljević Nikica N. 
Published: February 2023

In the present article the aim is to demonstrate that one of the ways to teach literature today, in the new millennium, when literary studies do not encourage interest among the new generations, could be through its relationship with other sciences, for example, with ecology. Since the 1970's, when ecocriticism was created, in a literary text the idea is to try to analyse the relationship between the individual and nature. Starting from the fact that in nature there are balanced relations, the ecocriticism is trying to overcome the hierarchical order imposed in the society by the secular centralism. The result of this order are the members that are marginalised and oppressed, the victims of the imposition of the concept of the vertical society which implies the dominance of some members over others.
In the analysis the aim is to show that there are some contemporary literary texts that witness the attempt of exclusion of some characters, such as, for example, in the migrant literature in Italy, where the characters-immigrants are frequently discriminated. According to ecocriticism, in order to achieve a sustainable society, it is necessary to overcome these dicriminatory mechanism. Therefore, with this paper we try to find some literary examples in which, by the means of the autobiographical testimony, this attempt of dominance is rejected by the characters and they eventually find the way to integrate into the new society as well as to overcome exclusion and discrimination. In the analysis we examine some of these examples that we find in the literary work of the two contemporary authoresses in Italy: Igiaba Scego, and Laila Wadia.
Assessment of the hydrological and coupled soft computing models, based on different satellite precipitation datasets, to simulate streamflow and sediment load in a mountainous catchment
Authors: Khan Muhammad Adnan , Stamm Jürgen 
Published: February 2023

Abstract
This study evaluated the performance and hydrologic utility of four different satellite precipitation datasets (SPDs), including GPM (IMERG_F), PERSIANN_CDR, CHIRPS, and CMORPH, to predict daily streamflow and SL using the SWAT hydrological model as well as SWAT coupled soft computing models (SCMs) such as artificial neural networks (SWAT-ANNs), random forests (SWAT-RFs), and support vector regression (SWAT-SVR), in the mountainous Upper Jhelum River Basin (UJRB), Pakistan. SCMs were developed using the outputs of un-calibrated SWAT models to improve the predictions. Overall, the GPM shows the highest performance for the entire simulation with R2 and PBIAS varying from 0.71 to 0.96 and −13.1 to 0.01%, respectively. For the best GPM-based models, SWAT-RF showed a superior ability to simulate the entire streamflow with R2 of 0.96, compared with the SWAT-ANN (R2 = 0.90), SWAT-SVR (R2 = 0.87), and SWAT-CUP (R2 = 0.71). Similarly, SWAT-ANN presented the best performance capability to simulate the SL with an R2 of 0.71, compared with the SWAT-RF (R2 = 0.66), SWAT-SVR (R2 = 0.52), and SWAT-CUP (R2 = 0.42). Hence, hydrological coupled SCMs based on SPDs could be an effective technique for simulating hydrological parameters, particularly in complex terrain where gauge network density is low or uneven.
Ultrasonication Induced Alterations in Physicochemical and Functional
Properties of Myosin
Authors: Saleem Rashid , Ahmad Riaz 
Published: February 2023

Background:
Several reports have indicated that ultrasonication can change the solubility
of muscle proteins and improves the functional properties of meat and isolated muscle proteins.
Moreover, available literature suggests that ultrasonication can significantly improve the gelling
properties of muscle proteins.

Objectives:
The present study was carried out to investigate the effect of low-frequency
ultrasonication on the secondary structure of myosin and the impact of these structural changes on
solubility and gelling ability.

Methods:
Myosin from breast muscles (Pectoralis major) of broiler chicken was extracted and
exposed to low-frequency ultrasonication for 30 min. Four aliquots collected at the interval of 5, 10,
20, and 30 min were analysed for change in ATPase activity, sulfhydryl content, surface
hydrophobicity, alpha-helicity. The possible impact of these changes on heat-induced gelation was
observed through electron micrographs.

Results:
Ultrasonication reduced the enzymatic activity of myosin and increased the reactive
sulfhydryl content. Decreased α-helicity and increased intrinsic fluorescence displayed significant
structural changes at the secondary and tertiary levels. Myosin aggregation, as indicated by electron
micrographs, showed a marked decrease. The microstructure of myosin gels displayed a distinct
correlation with ultrasonication-induced structural changes. Furthermore, improved microstructure led
to a significant increase in the water retention capacity of myosin gels.

Conclusion:
In conclusion, ultrasonication of myosin caused a marked change in structure at the
tertiary and secondary levels. Structural changes apparently confined within the globular head region
and rod portion of myosin were displayed by reduced enzymatic activity and improved
gelation/solubility. Results of our study convincingly showed that ultrasonication improved the
microstructure of myosin gels resulting in increased WHC.
Aloperine Prevents Migration, Invasion, and Adhesion by Upregulating
TIMP-4 in Human Bladder Cancer Cells
Authors: Qiu Mingning , Yu Liming , Liang Jinglan , Xia Juan , Wang Xuguang , Liu Jie 
Published: February 2023

Background:
Aloperine (ALO) is an important active component of quinolizidine alkaloids
in Sophora flavescens A and Sophora alopecuroides L, and has effective anticancer activity against
multiple cancers. However, the influence and mechanism of ALO on migration, invasion, and
adhesion in bladder cancer cells remain unclear.

Objective:
The aim of this study is to determine the anticancer effect of ALO on migration, invasion,
and adhesion in bladder cancer cells and to investigate its potential TIMP-4-related mechanism.

Methods:
Cell viability, cytotoxicity, wound healing, Transwell invasion, cell adhesion, real-time
qPCR, western blot, and ELISA assays were performed to analyze the effect of ALO on migration,
invasion, and adhesion in bladder cancer 5637 and UM-UC-3 cells. Furthermore, the anti-TIMP-4
antibody was used to explore the potential effect on ALO-inhibited bladder cancer cells.

Results:
We have found that ALO significantly suppressed migration, invasion, and adhesion in
bladder cancer cells. Furthermore, ALO could downregulate the expression of MMP-2 and MMP-9
mRNAs and proteins, and increase the expression of TIMP-4 mRNA and protein. Moreover, the anti-
TIMP-4 antibody reversed the prevention of migration, invasion, and adhesion in ALO-treated bladder
cancer cells.

Conclusion:
The data in this study suggest that ALO suppressed migration, invasion, and adhesion in
bladder cancer cells by upregulating the expression of TIMP-4.
LSINCT5: A Novel lncRNA in Cancers
Authors: Qiu Xinyan , Chen Jinlan 
Published: February 2023

Background:
Long chain non-coding RNAs (lncRNA) are a kind of transcript
that is around 200 nucleotides long and can engage in life activities via epigenetic, transcriptional,
and post-transcriptional regulation. One of the key members of lncRNAs,
long stress-induced noncoding transcripts 5 (LSINCT5), is localized at Chr 5p and has
been reported to be abnormally expressed in a range of cancers. We present a comprehensive
review of LSINCT5's aberrant expression and regulatory mechanisms in malignant
tumors.

Methods:
The included studies were retrieved and summarized through the PubMed
database using the keywords “LSINCT5” and “Cancer” in detail.

Results:
LSINCT5 behaves as an oncogene and abundantly expresses in malignant tumorigenesis
and progression. By sponging microRNAs (miRNA), interacting with proteins,
participating in cellular transduction, and being regulated by transcription factors,
LSINCT5 can stimulate malignant behavior in a variety of tumor cells, including proliferation,
migration, invasion, and epithelial-mesenchymal transition (EMT). Furthermore,
dysregulated LSINCT5 is usually associated with a poor prognosis.

Conclusion:
LSINCT5 has the potential to become a tumor diagnostic and prognostic
marker, generating new access to clinical applications.
In-vitro and In-vivo Identification, Absorbtion and Metabolism Network Analysis of
Filifolium sibiricum Flavonoids Dropping Pill by UHPLC-Q-TOF-MS
Authors: Ma Rui-Ting , Han Ji-Xin , Qiao Jun-Chan , Tong Li-Jun , Chen Li-Xia 
Published: February 2023

Background:
Filifolium sibiricum flavonoids dropping pill (FSFp), a unique Chinese Filifolii sibirici
herba extract preparation, has the potential as an alternative therapy against S. aureus infection (SA) and antiinfection.
However, its chemical composition and in vivo metabolism characteristics remain unknown, which limits
its clinical application.

Methods:
Here, we aimed to understand the in vitro and in vivo material basis of FSFp. Ultra-performance liquid
chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) was used to identify
chemicals in FSFp as well as its phase I and phase II reaction metabolites in plasma, urine and feces.

Results:
A total of 38 chemicals were characterized in FSFp, including 22 flavonoids, 10 organic acids, 3 chromones,
1 aromatic ketone, 1 coumarin, and 1 ligan. After analysis of the drugged bio-samples, a total of 21 compounds were
found in urine, and 16 of them were found in feces, but only one was found in plasma. In addition, 56 FSFp-related
metabolites were characterized, of which 56 were in urine, 4 in feces, and 8 in plasma.

Conclusion:
This is the first comprehensive research of FSFp on chemical constituents and metabolic profiles. It was
expected that this study would offer reliable support for further investigation of FSFp.
Cancer-induced Pain Management by Nanotechnology-based Approach
Authors: Kundu Chanakya Nath , Dash Somya Ranjan 
Published: February 2023

Abstract:
Cancer patients frequently report experiencing pain as one of their symptoms. Cancerrelated
pain is often caused by the tumor itself, especially when the tumor is pressing on nerves. In
addition to the pain caused by the tumor itself, patients also experience discomfort from the
treatment, such as surgery, chemotherapy, radiation therapy, and the diagnostic procedures. The
majority of today's pain therapies rely on opioid analgesics, which have not been shown to be
effective. The adverse effects of opioids and their addictive properties call for the development of
innovative treatment techniques. Nanotechnology offers answers to the issues raised above, which
are related to the utilization of more conventional modes of therapy. These nanotechnology-based
nanotherapeutics reduce the systemic toxicity, offering outstanding selectiveness and prolonged
release of the analgesic drugs at the target site. Thus, these reduce cancer-induced pain in the
patients. In this article, we will explain the mechanism behind the most common types of pain that
are caused by cancer, including neuropathic, somatic, and visceral pain. In addition, a
comprehensive discussion is held on the use of various nanotherapeutics as analgesic drug carriers,
as well as on their impacts and the potential opportunities that lie ahead in the field of cancer pain
treatment.
The Advances in Chitosan-based Drug Delivery Systems for Colorectal
Cancer: A Narrative Review
Authors: Ali Diyar Salahuddin , Othman Hazha Omar , Anwer Esra Tariq 
Published: February 2023

Abstract:
Colorectal cancer (CRC) is considered a lethal cancer all around the world, and its incidence
has been reported to be increasing. Chemotherapeutic drugs commonly used for treating this
cancer have shown some drawbacks, including toxicity to healthy cells and non-precise delivery.
Thus, there is a necessity for discovering novel diagnostic and therapeutic options to increase the
survival rate of CRC patients. Chitosan, as a natural polymer, has attracted a lot attention during
the past years in different fields, including cancer. Studies have indicated that chitosan-based materials
play various roles in prevention, diagnosis, and treatment of cancers. Chitosan nanoparticles
(NPs) have been shown to serve as anti-cancer agents, which provide sustained drug release and
targeted delivery of drugs to the tumor site. In this paper, we review available literature on the
roles of chitosan in CRC. We discuss the applications of chitosan in designing drug delivery systems
as well as anti-cancer activities of chitosan and involved signaling pathways.