bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond perception: Spatial analysis of detached ADU potential on residential lots in Windsor, Ontario
Authors: Cipkar Sarah , Maoh Hanna , Dimatulac Terence , Fathers Frazier , Arcis Shereen , Smit Anneke 
Published: April 2023

AbstractThis paper analyzes the spatial potential of detached additional dwelling units (ADUs) in Windsor, Ontario. A new GIS model, which integrates various geoprocessing commands in ArcGIS 10.8.1, is developed to calculate whether the minimum allowable size of a detached ADU can fit within the total buildable area of a residential property, based on the setbacks, the lot coverage requirements, and other factors (such as parking and flood plain areas). The model uses publicly sourced data that were obtained from the City of Windsor's Open Data Portal. More specifically, individual residential parcels and associated building footprints along with street centerlines are used as inputs to the model. The outputs are then categorized into three types (suitable, potentially suitable, and not suitable) to demonstrate where detached ADUs can be built in compliance with the local zoning bylaws, on both an individual lot basis and at an aggregate level. The conducted analysis reveals the potential of existing residential neighbourhoods in a mid‐size city, and has many implications for homeowners, policymakers, and researchers with respect to increasing housing supply within current Canadian municipalities.
Debate: Don't mind the gap – why do we not care about the gender gap in common mental health difficulties?
Authors: Patalay Praveetha , Demkowicz Ola 
Published: April 2023

There is a substantial gender gap in common mental health difficulties such as depression and anxiety, and evidence on drivers of this gap is sparse. Yet, the current tendency in the field is to treat it as inevitable, and its drivers are rarely examined as a worthwhile question to pursue. We discuss possible reasons for this oversight, while highlighting the need to reform research priorities and systems to ensure this issue receives the investment and interest necessary to inform better prevention and support. We emphasise the need to meaningfully engage with women on the gender mental health gap to better inform investigations into salient drivers and, in turn, efforts toward change. We challenge the research community to question such pervasive disinterest in this large inequality disproportionately affecting over half the population, to prevent and narrow this for future generations.
Ultra‐processed food consumption and dental caries in adolescents from the 2004 Pelotas Birth Cohort study
Authors: da Silva Nathalia Ribeiro Jorge , de Camargo Maria Beatriz Junqueira , dos Vaz Juliana Santos , Correa Marcos Britto , Matijasevich Alicia , da Silva dos Santos Iná , Cascaes Andreia Morales 
Published: April 2023

AbstractObjectiveTo investigate the relationship between ultra‐processed food (UPF) consumption and dental caries in adolescents.MethodsData from 996 adolescents aged 12–13 years who participated in an oral health sub‐study of the 2004 Pelotas Birth Cohort in southern Brazil were analysed. The main exposure was daily UPF consumption at age 10–11 years, measured by a food frequency questionnaire containing 24 UPF items defined based on the NOVA system. UPF consumption was calculated in frequency, grams and calories, in general and for six types of food (biscuits, savoury snacks and sugar‐sweetened cereals; ultra‐processed meats and fats; sweets; fast food and instant noodles; soft drinks and artificially flavoured drinks; and sweetened milk and powdered chocolate). The outcome was dental caries, measured according to the decayed, missing and filled indexes (DMFS and dmfs) at age 12–13 years. Poisson regression models were used to analyse the association between UPF consumption and dental caries, adjusting for socioeconomic and demographic variables, dental visits and oral hygiene.ResultsOverall, the daily UPF consumption in frequency, grams and calories was associated with caries. The findings were consistent for UPF consumption for all six food groups. The higher the UPF consumption, the higher the probability of having caries in adolescence. The associations between ultra‐processed meats and fats, and fast food and instant noodles intake with dental caries alert to the cariogenic potential of such UPF foods.ConclusionUltra‐processed food consumption was associated with greater caries burdens in young adolescents. The findings reinforce the need for interventions and public policies to reduce UPF consumption in adolescence.
Prognostic models to predict complete resolution of hypertension after adrenalectomy in primary aldosteronism: A systematic review and meta‐analysis
Authors: Marzano Luigi , Kazory Amir , Husain‐Syed Faeq , Ronco Claudio 
Published: April 2023

AbstractComplete resolution of hypertension (CRH) after adrenalectomy for primary aldosteronism is far from a certainty. Although several prognostic models have been proposed to predict outcome after adrenalectomy, studies have not clarified which of the available models can be used reliably in clinical practice. To identify, describe and appraise all prognostic models developed to predict CRH, and meta‐analyse their predictive performances. We searched MEDLINE, Embase and Web of Science for development and validation studies of prognostic models. After selection, we extracted descriptive statistics and aggregated area under the receiver operator curve (AUC) using meta‐analysis. From 25 eligible studies, we identified 12 prognostic models used for predicting CRH after total adrenalectomy in primary aldosteronism. We report the results for 3 models that had available data from at least 3 external validation studies: the primary aldosteronism surgical outcome (PASO) score (AUC: 0.81; 95% confidence interval [CI]: 0.74‒0.86; 95% predictive interval [PI]: 0.04‒1.00), Utsumi nomogram (AUC: 0.79; 95% CI: 0.72‒0.85; 95% PI: 0.03‒1.00) and the aldosteronoma resolution score (ARS) model (AUC: 0.77; 95% CI: 0.74‒0.80; 95% PI: 0.59‒0.86 for all studies and AUC: 0.80; 95% CI: 0.75‒0.85; 95% PI: 0.57‒0.93 for the studies with the same adrenal vein sampling‐guided adrenalectomy rate compared to the models meta‐analysed). The PASO score, Utsumi nomogram and ARS model showed comparable discrimination performance to predict CRH in primary aldosteronism. Unlike the ARS model, the number of external validation studies for the PASO score and the Utsumi nomogram was relatively low to draw definite conclusions.
Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA/p38MAPK signaling pathway
Authors: Li Xin , Shi Huimei , Zhang Di , Jing Bei , Chen Zhenni , Zheng Yachun , Chang Shiquan , Gao Li , Zhao Guoping 
Published: April 2023

AbstractBackgroundThis study aimed to investigate the potential mechanism of paeonol in the treatment of neuropathic pain.MethodsRelevant mechanisms were explored through microglial pseudotime analysis and the use of specific inhibitors in cell experiments. In animal experiments, 32 SD rats were randomly divided into the sham operation group, the chronic constrictive injury (CCI) group, the ibuprofen group, and the paeonol group. We performed behavioral testing, ELISA, PCR, Western blotting, immunohistochemistry, and immunofluorescence analysis.ResultsThe pseudotime analysis of microglia found that RhoA, Rock1, and p38MAPK were highly expressed in activated microglia, and the expression patterns of these genes were consistent with the expression trends of the M1 markers CD32 and CD86. Paeonol decreased the levels of M1 markers (IL1β, iNOS, CD32, IL6) and increased the levels of M2 markers (IL10, CD206, ARG‐1) in LPS‐induced microglia. The expression of iNOS, IL1β, RhoA, and Rock1 was significantly increased in LPS‐treated microglia, while paeonol decreased the expression of these proteins. Thermal hyperalgesia occurred after CCI surgery, and paeonol provided relief. In addition, paeonol decreased the levels of IL1β and IL8 and increased the levels of IL4 and TGF‐β in the serum of CCI rats. Paeonol decreased expression levels of M1 markers and increased expression levels of M2 markers in the spinal cord. Paeonol decreased IBA‐1, IL1β, RhoA, RhoA‐GTP, COX2, Rock1, and p‐p38MAPK levels in the spinal dorsal horn.ConclusionPaeonol relieves neuropathic pain by modulating microglial M1 and M2 phenotypes through the RhoA/p38 MAPK pathway.
Cardiac adverse events associated with quetiapine: Disproportionality analysis of FDA adverse event reporting system
Authors: Shu Yamin , Ding Yiling , Liu Lulu , Zhang Qilin 
Published: April 2023

AbstractObjectiveQuetiapine, an atypical second‐generation antipsychotic drug, is approved for treatment of schizophrenia, bipolar disorder, and depression. Due to the limitations of clinical trials, the association between quetiapine and rare cardiac adverse events (AEs) is still unclear. This study is to evaluate quetiapine‐associated cardiac AEs through data mining of FDA Adverse Event Reporting System (FAERS).MethodsReporting odds ratio (ROR) was used to quantify the signals of quetiapine‐related cardiac AEs from the first quarter (Q1) of 2018–2022 Q1. Serious and nonserious cases were compared, and signals were prioritized using a rating scale.ResultsA total of 1004 cases of quetiapine‐associated cardiac AEs were identified, with 31 signals being detected, among which 13 AEs were identified as new and unexpected signals. Besides, nine and 22 cardiac AEs were identified as moderate and weak clinical priority. The median TTO for moderate and weak clinical priority signals were 0 and 4 days, respectively. All of the cardiac AEs had early failure type characteristics, suggesting that most of the patients developed cardiac AEs in a few days after quetiapine treatment, and that the risk of cardiac AEs occurrence would be gradually decreased over time.ConclusionOur study provided valuable evidence for health‐care professionals to mitigate the risk of quetiapine‐associated cardiac AEs based on an extensive analysis of a real‐world, large‐sample FAERS database, and prioritize cardiac AE signals.
Sofa dermatitis: Value of patch test with 2‐(thiocyanomethylthio)benzothiazole
Authors: Herman Anne , Marot Liliane , Baeck Marie 
Published: April 2023

AbstractBackgroundIn 2008, numerous cases of allergic contact dermatitis caused by leather chairs (sofa dermatitis) were reported, with dimethylfumarate being the culprit allergen. However, octylisothiazolinone, methylisothiazolinone and cobalt have also been associated with cases of sofa dermatitis. An antifungal agent, 2‐(thiocyanomethylthio)benzothiazole (TCMTB), has also previously been described as a contact allergen in leather.Materials and MethodsSeven patients were referred to the Department of Dermatology of the Cliniques universitaires Saint‐Luc, Brussels, Belgium with suspicion of allergic contact dermatitis caused by leather sofas. They were patch tested with the European Baseline Series, additional series (according to the patients' history and clinical aspect of the eruption), dimethylfumarate (4/7 patients) and with TCMTB.ResultsAll seven patients presented a positive reaction to TCMTB and only one presented a concomitant positive reaction to dimethylfumarate. All patients showed clinical improvement after avoiding contact with their leather sofa.Conclusion2‐(Thiocyanomethylthio)benzothiazole (TCMTB) is probably an underestimated allergen present in leather chairs (responsible for the so‐called ‘sofa dermatitis’), and more generally in leather objects. It is, therefore, important to test with TCMTB 0.1% petrolatum in case of contact dermatitis related with leather products.
Community‐based physical activity interventions for adolescents and adults with complex cerebral palsy: A scoping review
Authors: Morgan Prue , Cleary Stacey , Dutia Iain , Bow Keegan , Shields Nora 
Published: April 2023

AbstractAimTo identify implementation strategies and safety outcomes (adverse events) of community‐based physical activity interventions for adolescents and adults with complex cerebral palsy (CP).MethodFive electronic databases were systematically searched to April 2022. Data were extracted on the implementation and safety of physical activity interventions for adolescents and adults with CP, classified in Gross Motor Function Classification System (GMFCS) levels IV and V, delivered in a community setting.ResultsSeventeen studies with 262 participants (160 participants classified in GMFCS levels IV or V) were included. Community settings included schools (n = 4), participants' homes (n = 3), gymnasia (n = 2), swimming pools (n = 2), and other settings (n = 4). Most studies specified medical or safety exclusion criteria. Implementation strategies included pre‐exercise screening, use of adapted equipment, familiarization sessions, supervision, physical assistance, and physiological monitoring. Attendance was high and attrition low. Nine studies reported non‐serious, expected, and related events. Four studies reported minor soreness and four studies reported minor fatigue post‐exercise. Serious adverse events related to exercise were infrequent (reported for 4 of 160 participants [<2%]: three participants withdrew from an exercise programme and one participant ceased exercise for a short period). Most frequently reported was pain, requiring temporary exercise cessation or programme change, or study withdrawal (three participants).InterpretationFor most adolescents and adults with CP classified in GMFCS levels IV and V, physical activity interventions can be safely performed in a community setting, without post‐exercise pain or fatigue, or serious adverse events.What this paper adds

Supervised community‐based physical activity interventions can be safely performed by people with complex cerebral palsy.
Post‐exercise pain or fatigue was not common among those classified in Gross Motor Function Classification System levels IV or V.
Serious adverse events are infrequent when exercising in community settings, with safety strategies.
Bridging the gap between supply chain management practice and curriculum: A location analytics exercise
Authors: Ritchie William J. , Kerski Joseph , Novoa Luis J. , Tokman Mert 
Published: April 2023

AbstractThis teaching brief explores how and why location analytics should be taught in business schools using three objectives. First, an explanation is provided for the importance of including location analytics in the standard business school curriculum—especially in the field of supply chain management. Second, a lack of GIS‐based location analytics methods in business school curricula is demonstrated. Third, a three‐part location analytics exercise is introduced to contribute to the supply chain management curriculum. The proposed exercise utilizes the output of a GIS‐based location analytics software (namely, Esri's ArcGIS Online) as the input for a location set covering problem that can be solved using an integer programming solver. The exercise can also be used as a stand‐alone example of GIS in a supply chain management course. This teaching brief aims to (1) develop a new method to use in teaching location analytics in supply chain management and analytics courses and (2) bridge an important gap between supply chain management practice and curriculum.
Human appropriation of net primary production as driver of change in landscape‐scale vertebrate richness
Authors: Reiter Karina , Plutzar Christoph , Moser Dietmar , Semenchuk Philipp , Erb Karl‐Heinz , Essl Franz , Gattringer Andreas , Haberl Helmut , Krausmann Fridolin , Lenzner Bernd , Wessely Johannes , Matej Sarah , Pouteau Robin , Dullinger Stefan 
Published: April 2023

AbstractAimLand use is the most pervasive driver of biodiversity loss. Predicting its impact on species richness (SR) is often based on indicators of habitat loss. However, the degradation of habitats, especially through land‐use intensification, also affects species. Here, we evaluate whether an integrative metric of land‐use intensity, the human appropriation of net primary production, is correlated with the decline of SR in used landscapes across the globe.LocationGlobal.Time periodPresent.Major taxa studiedBirds, mammals and amphibians.MethodsBased on species range maps (spatial resolution: 20 km × 20 km) and an area‐of‐habitat approach, we calibrated a “species–energy model” by correlating the SR of three groups of vertebrates with net primary production and biogeographical covariables in “wilderness” areas (i.e., those where available energy is assumed to be still at pristine levels). We used this model to project the difference between pristine SR and the SR corresponding to the energy remaining in used landscapes (i.e., SR loss expected owing to human energy extraction outside wilderness areas). We validated the projected species loss by comparison with the realized and impending loss reconstructed from habitat conversion and documented by national Red Lists.ResultsSpecies–energy models largely explained landscape‐scale variation of mapped SR in wilderness areas (adjusted R2‐values: 0.79–0.93). Model‐based projections of SR loss were lower, on average, than reconstructed and documented ones, but the spatial patterns were correlated significantly, with stronger correlation in mammals (Pearson's r = 0.68) than in amphibians (r = 0.60) and birds (r = 0.57).Main conclusionsOur results suggest that the human appropriation of net primary production is a useful indicator of heterotrophic species loss in used landscapes, hence we recommend its inclusion in models based on species–area relationships to improve predictions of land‐use‐driven biodiversity loss.
Post‐glacial range formation of temperate forest understorey herbs – Insights from a spatio‐temporally explicit modelling approach
Authors: Willner Wolfgang , Wessely Johannes , Gattringer Andreas , Moser Dietmar , Záveská Eliška , Dullinger Stefan , Schönswetter Peter , Hülber Karl 
Published: April 2023

AbstractAimOur knowledge of Pleistocene refugia and post‐glacial recolonization routes of forest understorey plants is still very limited. The geographical ranges of these species are often rather narrow and show highly idiosyncratic, often fragmented patterns indicating either narrow and species‐specific ecological tolerances or strong dispersal limitations. However, the relative roles of these factors are inherently difficult to disentangle.LocationCentral and south‐eastern Europe.Time period17,100 BP – present.Major taxa studiedFive understorey herbs of European beech forests: Aposeris foetida, Cardamine trifolia, Euphorbia carniolica, Hacquetia epipactis and Helleborus niger.MethodsWe used spatio‐temporally explicit modelling to reconstruct the post‐glacial range dynamics of the five forest understorey herbs. We varied niche requirements, demographic rates and dispersal abilities across plausible ranges and simulated the spread of species from potential Pleistocene refugia identified by phylogeographical analyses. Then we identified the parameter settings allowing for the most accurate reconstruction of their current geographical ranges.ResultsWe found a largely homogenous pattern of optimal parameter settings among species. Broad ecological niches had to be combined with very low but non‐zero rates of long‐distance dispersal via chance events and low rates of seed dispersal over moderate distances by standard dispersal vectors. However, long‐distance dispersal events, although rare, led to high variation among replicated simulation runs.Main conclusionsSmall and fragmented ranges of many forest understorey species are best explained by a combination of broad ecological niches and rare medium‐ and long‐distance dispersal events. Stochasticity is thus an important determinant of current species ranges, explaining the idiosyncratic distribution patterns of the study species despite strong similarities in refugia, ecological tolerances and dispersal abilities.
Headache and systemic lupus erythematosus: A narrative review
Authors: de Oliveira Igor , Sampaio Rocha‐Filho Pedro Augusto 
Published: April 2023

AbstractObjectiveTo review the epidemiology, the differential diagnosis, and the clinical and laboratory factors associated with the care management of headaches in patients with systemic lupus erythematosus (SLE).BackgroundSLE is a chronic autoimmune disease and in 12%–95% of patients, the nervous system is involved. Headache is a frequently reported, although nonspecific, symptom that may potentially represent serious underlying diagnoses. Primary headaches may also occur in these patients, thereby causing a negative and significant impact on their quality of life.MethodsThis is a narrative review. A literature review was conducted on the PubMed platform using the following terms: (1) headache and (2) lupus. All articles considered relevant were included. No limitations were imposed for the publication date.ResultsHeadache is a frequent symptom in patients with SLE. Although its prevalence is similar to the general population, headaches nonetheless tend to have a greater negative impact on these patients. Patients with SLE are more likely to experience headache due to vascular diseases such as cerebral venous sinus thrombosis, stroke, reversible cerebral vasoconstriction syndrome, posterior reversible encephalopathy syndrome, and vasculitis. Aseptic meningitis, neuroinfections, intracranial neoplasms, and intracranial hypertension or hypotension may also be a cause of headache in these patients. Although used in disease activity scores, the concept of lupus headache is controversial.ConclusionsHeadache is a frequent symptom in patients with SLE. An appropriate approach enables the potentially serious conditions, which are the causes of secondary headaches, to be recognized and treated, together with an appropriate diagnosis and treatment of primary headaches.
Multicenter retrospective study of stereotactic body radiotherapy for patients with previously untreated initial small hepatocellular carcinoma
Authors: Doi Yoshiko , Nagata Yasushi , Matsumoto Yasuo , Numata Kazushi , Sasaki Ryu , Yamada Takashi , Igaki Hiroshi , Imagumbai Toshiyuki , Katoh Norio , Yoshitake Tadamasa , Shimizuguchi Takuya , Fujioka Den , Inoue Minoru , Koide Yutaro , Kimura Tomoki , Ito Yoshinori 
Published: April 2023

AbstractAimWe aimed to verify the therapeutic efficacy and safety of stereotactic body radiotherapy (SBRT) for previously untreated initial small hepatocellular carcinoma (HCC) in a multicenter, retrospective study.MethodsPatients who underwent SBRT for HCC at the Japanese Society of Clinical Oncology (JCOG) member hospitals in Japan between July 2013 and December 2017 and met the following eligibility criteria were included: (1) initial HCC; (2) ≤3 nodules, ≤5 cm in diameter; (3) Child–Pugh score of A or B; and (4) unsuitability for or refusal of standard treatment. We analyzed the overall survival, recurrence‐free survival, and cumulative incidence of local recurrence rate, and adverse events directly related to SBRT.ResultsSeventy‐three patients with 79 lesions from 14 hospitals were analyzed. The median age was 77 years (range: 50–89 years), and the median tumor size was 23 mm (range: 6–50 mm). The median radiation dose was 40 Gy (range: 35–60 Gy) in five fractions (range: 4–8). The median follow‐up period was 45 months (range: 0–103 months). The 3‐year overall survival, recurrence‐free survival, and cumulative incidence of local recurrence rates were 69.9% (95% CI: 58.7%–81%), 57.9% (95% CI: 45.2%–70.5%), and 20.0% (95% CI: 11.2%–30.5%), respectively. Four cases (5.5%) of adverse events of grade 3 or higher were reported: three cases of grade 3 and one case of grade 4 (duodenal ulcer). No grade 5 toxicities were observed.ConclusionSBRT is a promising treatment modality, particularly for small HCCs, as they are not suitable for standard treatment.