bluuebunny/crossref_metadata_2025_split huggingface dataset:
The benefits of mind wandering on a naturalistic prospective memory task
Authors: Girardeau J. C. , Ledru R. , Gaston-Bellegarde A. , Blondé P. , Sperduti M. , Piolino P. 
Published: July 2023

AbstractMind wandering (MW) occurs when our attention spontaneously shifts from the task at hand to inner thoughts. MW is often future-oriented and may help people remember to carry out their planned actions (Prospective Memory, PM). Past-oriented MW might also play a critical role in boosting PM performance. Sixty participants learned 24 PM items and recalled them during an immersive virtual walk in a town. The items were divided into event-based—EB and time-based—TB. During the PM retention phase, participants were randomly assigned to a high or a low cognitive load condition, in order to manipulate MW frequency. Some PM items were encoded before this MW manipulation (pre-PM) and some during the virtual walk (post-PM). A high MW frequency was linked with better global PM performances. Spontaneous past-oriented MW predicted better pre-EB retrospective PM retrieval, while spontaneous future-oriented MW predicted better Pre-EB prospective PM retrieval. Voluntary future-oriented MW predicted better post-EB retrospective retrieval. We highlighted, for the first time, a differential impact of spontaneous MW content depending on the PM component (retrospective or prospective). Past‐oriented MW is crucial for (re)consolidating PM intentions, and episodic future thinking MW for the execution of PM intentions. We discuss the twofold functional role of MW, namely, to consolidate an already programmed intention and to plan future actions.
Chemical doping to control the in-situ formed doping structure in light-emitting electrochemical cells
Authors: Huseynova Gunel , Ràfols-Ribé Joan , Auroux Etienne , Huang Ping , Tang Shi , Larsen Christian , Edman Ludvig 
Published: July 2023

AbstractThe initial operation of a light-emitting electrochemical cell (LEC) constitutes the in-situ formation of a p–n junction doping structure in the active material by electrochemical doping. It has been firmly established that the spatial position of the emissive p–n junction in the interelectrode gap has a profound influence on the LEC performance because of exciton quenching and microcavity effects. Hence, practical strategies for a control of the position of the p–n junction in LEC devices are highly desired. Here, we introduce a “chemical pre-doping” approach for the rational shifting of the p–n junction for improved performance. Specifically, we demonstrate, by combined experiments and simulations, that the addition of a strong chemical reductant termed “reduced benzyl viologen” to a common active-material ink during LEC fabrication results in a filling of deep electron traps and an associated shifting of the emissive p–n junction from the center of the active material towards the positive anode. We finally demonstrate that this chemical pre-doping approach can improve the emission efficiency and stability of a common LEC device.
Investigation of the therapeutic role of native plant compounds against colorectal cancer based on system biology and virtual screening
Authors: Alibakhshi Abbas , Malekzadeh Rahim , Hosseini Sayedeh Azimeh , Yaghoobi Hajar 
Published: July 2023

AbstractThis study investigated the anticancer effects of compounds extracted from native plants on colon cancer following drug–target-network analysis and molecular docking. Based on the ChEBI database, compounds were identified in medicinal plants and weeds in the Chaharmahal and Bakhtiari provinces of Iran. A drug–target network was constructed based on candidate colon cancer protein targets and selective compounds. Network pharmacology analysis was conducted against the identified compounds and subjected to molecular docking studies. Based on molecular dynamics simulations, the most efficient compounds were evaluated for their anticancer effects. Our study suggests that TREM1, MAPK1, MAPK8, CTSB, MIF, and DPP4 proteins may be targeted by compounds in medicinal plants for their anti-cancer effects. Multiorthoquinone, Liquiritin, Isoliquiritin, Hispaglabridin A, Gibberellin A98, Cyclomulberrin, Cyclomorusin A, and Cudraflavone B are effective anticancer compounds found in targeted medicinal plants and play an important role in the regulation of important pathways in colon cancer. Compounds that inhibit MIF, CTSB, and MAPK8-16 appear to be more effective. Additional in vitro and in vivo experiments will be helpful in validating and optimizing the findings of this study.
Organic electrochemical transistors printed from degradable materials as disposable biochemical sensors
Authors: Fumeaux Nicolas , Almeida Claudio Pinto , Demuru Silvia , Briand Danick 
Published: July 2023

AbstractTransient electronics hold promise in reducing electronic waste, especially in applications that require only a limited lifetime. While various degradable electronic and physical sensing devices have been proposed, there is growing interest in the development of degradable biochemical sensors. In this work, we present the development of an organic electrochemical transistor (OECT) with degradable electrodes, printed on an eco- and bioresorbable substrate. The influence of the design and materials for the contacts, channel and gate of the transducer, namely poly(3,4-ethylene dioxythiophene):polystyrene sulfonate (PEDOT:PSS) and carbon, is systematically evaluated for the development of OECT-based transient biosensors. The sensing capabilities of the electrochemical transistors are demonstrated with ionic solutions as well as for the enzyme-based detection of glucose. The disposable OECTs show comparable performance to their non-degradable counterparts. Their integration with highly conductive degradable and printable zinc tracks is studied for the realization of interconnects. These eco-friendly OECTs may find applications as disposable and sustainable biochemical sensors, and constitute a step towards bioresorbable biosensors.
A randomized clinical trial of omega-3 fatty acid and vitamin D supplementation on electrocardiographic risk profiles
Authors: Tikkanen Jani T. , Soliman Elsayed Z. , Pester Julie , Danik Jacqueline S. , Gomelskya Natalia , Copeland Trisha , Lee I.-Min , Buring Julie E. , Manson JoAnn E. , Cook Nancy R. , Albert Christine M. 
Published: July 2023

AbstractBeneficial and adverse associations with arrhythmias have been reported for omega-3 fatty acids (omega-3 FA) and Vitamin D. The 12 lead electrocardiogram (ECG) contains quantitative measures reflecting diverse aspects of electrophysiology that might provide insights into mechanisms underlying these associations. In a pre-specified ancillary study of the VITaminD and omegA-3 (VITAL) trial, we examined the effect of 1 g of marine omega-3 FA per day, comprised of 460 mg eicosapentanoic acid and 380 mg of docosahexaenoic acid, and 2000 IU VitaminD3 per day on ECG characteristics associated with atrial and ventricular arrhythmias among individuals age 50 years or greater. A total of 911 study participants underwent ECGs at baseline and again at 2 years after the randomization. Individuals randomized to active omega-3 FA demonstrated significant net increase in PR-interval duration (p = 0.005) and P-wave duration (p = 0.03) as well significant net decrease in P-wave amplitude (p = 0.037) as compared to placebo. RMSSD increased to a greater extent in the omega-3 FA arm compared to placebo (p = 0.040). For Vitamin D3, the Cornell voltage increased to a lesser extent in the participants assigned to active treatment as compared to placebo (p = 0.044). There were no other significant differences in QRS, QTc, Cornell voltage or heart rate. Thus, randomized treatment with omega-3 FA supplements resulted in changes on the ECG that are potentially reflective of heightened vagal tone and/or slowing of intraatrial and AV conduction. Vitamin D3 supplementation resulted in modest reductions in progressive LV voltage suggestive of a potential antihypertrophic effect.Trial registration ClinicalTrials.gov Identifiers: NCT01169259, NCT02178410 (06/26/2010 and 06/30/2014).
Preliminary experience of CT imaging of the ischaemic brain penumbra through spectral processing of multiphasic CTA datasets
Authors: Duprez T. , Vlassenbroek A. , Peeters A. , Poncelet P. A. , Levecque E. , Austein F. , Pahn G. , Nae Y. , Abdallah S. , Coche E. 
Published: July 2023

AbstractTo assess ischaemic penumbra through the post-processing of the spectral multiphasic CT Angiography (mCTA) data in acute ischaemic stroke (AIS) patients. Thirty one consecutive patients strongly suspected of severe Middle Cerebral Artery AIS presenting less than 6 h after onset of symptoms or with unknown time of onset of symptoms underwent a standardized CT protocol in spectral mode including Non Contrast CT, mCTA, and Perfusion CT (CTP) on a dual-layer MDCT system. Areas disclosing delayed enhancement on iodine density (ID) maps were highlighted by subtraction of the serial mCTA datasets. Two neuroradiologists independently rated the correspondence between delayed enhancing areas at mCTA and the penumbral/infarcted areas delineated by two validated CTP applications using a 5-levels scoring scale. Interobserver agreement between observers was evaluated by kappa statistics. Dose delivery was recorded for each acquisition. Averaged correspondence score between penumbra delineation using subtracted mCTA-derived ID maps and CTP ones was 2.76 for one application and 2.9 for the other with best interobserver agreement kappa value at 0.59. All 6 stroke mimics out of the 31 patients’ cohort were correctly identified. Average dose delivery was 7.55 mSv for the whole procedure of which CTP accounted for 39.7%. Post-processing of spectral mCTA data could allow clinically relevant assessment of the presence or absence of ischaemic penumbra in AIS-suspected patients if results of this proof-of-concept study should be confirmed in larger patients’series.
Association of killer cell immunoglobulin-like receptors and their cognate HLA class I ligands with susceptibility to acute myeloid leukemia in Iranian patients
Authors: Mirzazadeh Sara , Bemani Peyman , Halimi Hossein , Sanaee Mohammad Nabi , Karami Narges , Ramzi Mani , Farjadian Shirin 
Published: July 2023

AbstractAcute myeloid leukemia (AML) is one of the most prevalent leukemia in adults. Among the various NK receptors, killer immunoglobulin-like receptors (KIRs) carry out indispensable roles in NK cell development and function through engaging with class I human leukocyte antigens (HLA-I) as their ligands. Besides divergent KIR and HLA loci, KIR/HLA-I combinations have a significant effect on NK cell response. In this case–control study, we aimed to verify the association of KIR/HLA-I combinations with susceptibility to AML in the Southwestern Iranian population. KIR and HLA genotyping was performed with PCR-SSP by some novel primers for 181 patients with AML and 181 healthy controls. According to our results, the frequencies of KIR3DS1 (p = 0.0001, OR = 2.32, 95% CI 1.51–3.58), KIR2DS4fl (p = 0.02, OR = 1.53, 95% CI 1.05–2.21), CxT4 genotypes (p = 0.03, OR = 2.0, 95% CI 1.05–3.82), and T4 gene cluster (p = 0.01, OR = 1.99, 95% CI 1.17–3.41) were significantly higher in patients than controls, while C1/C2 genotype (p = 0.00002, OR = 0.39, 95% CI 0.25–0.61), HLA-A Bw4 (p = 0.02, OR = 0.6, 95% CI 0.38–0.94), and HLA-A*11 (p = 0.03, OR = 0.57, 95% CI 0.34–0.95) alleles were more frequent in controls. In addition, inhibitory (i)KIR/HLA-I combinations analysis revealed higher frequencies of KIR2DL1( +)/HLA-C2( +), KIR2DL2/3( +)/HLA-C1( +), KIR3DL1( +)/HLA-A Bw4( +), and KIR3DL2( +)/HLA-A*03/11( +) in the control group (p = 0.002, OR = 0.49, 95% CI 0.3–0.78; p = 0.04, OR = 0.62, 95% CI 0.39–0.99; p = 0.04, OR = 0.63, 95% CI 0.4–0.99; and p = 0.03, OR = 0.62, 95% CI 0.4–0.95, respectively). Overall, the number of iKIR/HLA-I combinations was more in the control group. Moreover, KIR3DS1( +)/HLA-B Bw4Ile80( +) and the sum of HLA-B Bw4/A Bw4 combined with KIR3DS1 as activating KIR/HLA-I combinations were more frequent among patients than controls (p = 0.01, OR = 1.99, 95% CI 1.14–3.49 and p = 0.005, OR = 1.97, 95% CI 1.22–3.19, respectively). In conclusion, our results postulate that inhibitory combinations play a protective role against AML by developing potent NK cells during education. It is noteworthy that KIR/HLA-I combination studies can be applicable in donor selection for allogeneic NK cell therapy in hematological malignancies.
Long-term effects of subthalamic nucleus deep brain stimulation on speech in Parkinson’s disease
Authors: Gessani Annalisa , Cavallieri Francesco , Fioravanti Valentina , Campanini Isabella , Merlo Andrea , Di Rauso Giulia , Damiano Benedetta , Scaltriti Sara , Bardi Elisa , Corni Maria Giulia , Antonelli Francesca , Cavalleri Francesca , Molinari Maria Angela , Contardi Sara , Menozzi Elisa , Fraternali Alessandro , Versari Annibale , Biagini Giuseppe , Fraix Valérie , Pinto Serge , Moro Elena , Budriesi Carla , Valzania Franco 
Published: July 2023

AbstractBilateral subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment in advanced Parkinson’s Disease (PD). However, the effects of STN-DBS on speech are still debated, particularly in the long-term follow-up. The objective of this study was to evaluate the long-term effects of bilateral STN-DBS on speech in a cohort of advanced PD patients treated with bilateral STN-DBS. Each patient was assessed before surgery through a neurological evaluation and a perceptual-acoustic analysis of speech and re-assessed in the long-term in different stimulation and drug conditions. The primary outcome was the percentage change of speech intelligibility obtained by comparing the postoperative on-stimulation/off-medication condition with the preoperative off-medication condition. Twenty-five PD patients treated with bilateral STN-DBS with a 5-year follow-up were included. In the long-term, speech intelligibility stayed at the same level as preoperative values when compared with preoperative values. STN-DBS induced a significant acute improvement of speech intelligibility (p < 0.005) in the postoperative assessment when compared to the on-stimulation/off-medication and off-stimulation/off-medication conditions. These results highlight that STN-DBS may handle speech intelligibility even in the long-term.
Quantum range-migration-algorithm for synthetic aperture radar applications
Authors: Waller Erik H. , Keil Andreas , Friederich Fabian 
Published: July 2023

AbstractThe 3D range-migration algorithm (RMA) and its 2D equivalent, the omega-k algorithm, are employed in a wide range of applications where reconstruction of synthetic aperture data is required, from satellite radar imaging of planets over seismic imaging of the earth crust, down to phased-array ultrasound and ultrasonic application, and recently in-line synthetic aperture radar for non-destructive testing. These algorithms are based on Fourier transforms and share their time-complexity. This limits highly-resolved measurement data to be processed at high speeds which would be advantageous for modern production feed lines. In this publication, we present the development and implementation of the RMA on a quantum computer that scales favourably compared to the time complexity of the classical RMA. We compare reconstruction results of simulated and measured data of the classical and quantum RMA. Hereby, the quantum RMA is run on a quantum simulator backend as well as on IBM’s Q System One quantum computer. The results show that real world applications and testing tasks may benefit from future quantum computers.
Natural resveratrol analogs differentially target endometriotic cells into apoptosis pathways
Authors: Gołąbek-Grenda Agata , Kaczmarek Mariusz , Juzwa Wojciech , Olejnik Anna 
Published: July 2023

AbstractThe specific characteristics of endometriotic cells are their ability to evade the apoptotic machinery and abnormal response to apoptotic stimuli. Natural-originated compounds may constitute a beneficial strategy in apoptosis modulation in endometriosis. We investigated and compared the potency of natural resveratrol analogs, including piceatannol, polydatin, and pterostilbene, in targeting cell death pathways, including apoptosis-related morphologic and biochemical processes, alongside the modulation of the critical genes expression. Upon resveratrol and pterostilbene treatment, a significant reduction of endometriotic cell viability and an increased apoptotic proportion of cells were noted. The lower antiproliferative potential was found for piceatannol and polydatin. Endometrial stromal T HESC cells were significantly more resistant than endometriotic epithelial 12Z cells to the cytotoxic activity of all analyzed compounds. They differentially affected endometriotic cell viability, cell cycle, anti- and proapoptotic genes regulation, caspases expression and enzymatic activity, and DNA fragmentation. Pterostilbene-mediated endometriotic cell apoptosis modulation was confirmed to be most effective but without evident caspase 3 upregulation. Our study provides valuable insight into the apoptogenic activity of resveratrol and its natural analogs in endometriotic cells. Data obtained revealed the highest therapeutic potential of pterostilbene by effectively targeting cell death determinants in endometriosis, strengthening its optimization in further extensive research.
Actionability classification of variants of unknown significance correlates with functional effect
Authors: Johnson Amber , Ng Patrick Kwok-Shing , Kahle Michael , Castillo Julia , Amador Bianca , Wang Yujia , Zeng Jia , Holla Vijaykumar , Vu Thuy , Su Fei , Kim Sun-Hee , Conway Tara , Jiang Xianli , Chen Ken , Shaw Kenna R. Mills , Yap Timothy A. , Rodon Jordi , Mills Gordon B. , Meric-Bernstam Funda 
Published: July 2023

AbstractGenomically-informed therapy requires consideration of the functional impact of genomic alterations on protein expression and/or function. However, a substantial number of variants are of unknown significance (VUS). The MD Anderson Precision Oncology Decision Support (PODS) team developed an actionability classification scheme that categorizes VUS as either “Unknown” or “Potentially” actionable based on their location within functional domains and/or proximity to known oncogenic variants. We then compared PODS VUS actionability classification with results from a functional genomics platform consisting of mutant generation and cell viability assays. 106 (24%) of 438 VUS in 20 actionable genes were classified as oncogenic in functional assays. Variants categorized by PODS as Potentially actionable (N = 204) were more likely to be oncogenic than those categorized as Unknown (N = 230) (37% vs 13%, p = 4.08e-09). Our results demonstrate that rule-based actionability classification of VUS can identify patients more likely to have actionable variants for consideration with genomically-matched therapy.
Anomalous conductance quantization of a one-dimensional channel in monolayer WSe2
Authors: Boddison-Chouinard Justin , Bogan Alex , Barrios Pedro , Lapointe Jean , Watanabe Kenji , Taniguchi Takashi , Pawłowski Jarosław , Miravet Daniel , Bieniek Maciej , Hawrylak Pawel , Luican-Mayer Adina , Gaudreau Louis 
Published: July 2023

AbstractAmong quantum devices based on 2D materials, gate-defined quantum confined 1D channels are much less explored, especially in the high-mobility regime where many-body interactions play an important role. We present the results of measurements and theory of conductance quantization in a gate-defined one-dimensional channel in a single layer of transition metal dichalcogenide material WSe2. In the quasi-ballistic regime of our high-mobility sample, we report conductance quantization steps in units of e2/h for a wide range of carrier concentrations. Magnetic field measurements show that as the field is raised, higher conductance plateaus move to accurate quantized values and then shift to lower conductance values while the e2/h plateau remains locked. Based on microscopic atomistic tight-binding theory, we show that in this material, valley and spin degeneracies result in 2 e2/h conductance steps for noninteracting holes, suggesting that symmetry-breaking mechanisms such as valley polarization dominate the transport properties of such quantum structures.
Fronto-parietal networks shape human conscious report through attention gain and reorienting
Authors: Liu Jianghao , Bayle Dimitri J. , Spagna Alfredo , Sitt Jacobo D. , Bourgeois Alexia , Lehongre Katia , Fernandez-Vidal Sara , Adam Claude , Lambrecq Virginie , Navarro Vincent , Seidel Malkinson Tal , Bartolomeo Paolo 
Published: July 2023

AbstractHow do attention and consciousness interact in the human brain? Rival theories of consciousness disagree on the role of fronto-parietal attentional networks in conscious perception. We recorded neural activity from 727 intracerebral contacts in 13 epileptic patients, while they detected near-threshold targets preceded by attentional cues. Clustering revealed three neural patterns: first, attention-enhanced conscious report accompanied sustained right-hemisphere fronto-temporal activity in networks connected by the superior longitudinal fasciculus (SLF) II-III, and late accumulation of activity (>300 ms post-target) in bilateral dorso-prefrontal and right-hemisphere orbitofrontal cortex (SLF I-III). Second, attentional reorienting affected conscious report through early, sustained activity in a right-hemisphere network (SLF III). Third, conscious report accompanied left-hemisphere dorsolateral-prefrontal activity. Task modeling with recurrent neural networks revealed multiple clusters matching the identified brain clusters, elucidating the causal relationship between clusters in conscious perception of near-threshold targets. Thus, distinct, hemisphere-asymmetric fronto-parietal networks support attentional gain and reorienting in shaping human conscious experience.
Regional genetic correlations highlight relationships between neurodegenerative disease loci and the immune system
Authors: Lona-Durazo Frida , Reynolds Regina H. , Scholz Sonja W. , Ryten Mina , Gagliano Taliun Sarah A. 
Published: July 2023

AbstractNeurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are devastating complex diseases resulting in physical and psychological burdens on patients and their families. There have been important efforts to understand their genetic basis leading to the identification of disease risk-associated loci involved in several molecular mechanisms, including immune-related pathways. Regional, in contrast to genome-wide, genetic correlations between pairs of immune and neurodegenerative traits have not been comprehensively explored, but could uncover additional immune-mediated risk-associated loci. Here, we systematically assess the role of the immune system in five neurodegenerative diseases by estimating regional genetic correlations between these diseases and immune-cell-derived single-cell expression quantitative trait loci (sc-eQTLs). We also investigate correlations between diseases and protein levels. We observe significant (FDR < 0.01) correlations between sc-eQTLs and neurodegenerative diseases across 151 unique genes, spanning both the innate and adaptive immune systems, across most diseases tested. With Parkinson’s, for instance,RAB7L1in CD4+ naïve T cells is positively correlated andKANSL1-AS1is negatively correlated across all adaptive immune cell types. Follow-up colocalization highlight candidate causal risk genes. The outcomes of this study will improve our understanding of the immune component of neurodegeneration, which can warrant repurposing of existing immunotherapies to slow disease progression.