bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integer topological defect annihilations drive polar ordering of epithelial monolayers
Authors: Lång Emma , Lång Anna , Blicher Pernille , Rognes Torbjørn , Dommersnes Paul , Bøe Stig Ove 
Published: May 2023

Abstract
The ability of epithelial monolayers to self-organize into a dynamic polarized state is essential for tissue regeneration, development, and tumor progression. However, the mechanisms governing long-range polar ordering in biological tissues remain unclear. Here we investigate the self-organizing behavior of quiescent epithelial monolayers that transit from a disordered, static state to a dynamic state with long-range polar order upon growth factor exposure. We demonstrate that the heightened self-propelled activity of monolayer cells leads to formation of ±1 topological defect pairs that subsequently undergo sequential annihilation, ultimately driving the spread of long-range polar order throughout the system. A computational model, which treats the monolayer as an active elastic solid, accurately replicates this behavior, and weakening of cell-to-cell interactions impedes defect annihilation and polar ordering. Furthermore, we have identified a set of fundamental rules that describe how topological defects can function as local organizers to spread order through the system. Lastly, we show that transient proliferation and re-annihilation of defect pairs facilitate a 180 degrees reorientation of the collective cell flow. Our study reveals a crucial role of topological defects in generating collective motion with long-range order, and provides insights into the underlying principles of active matter physics in biological systems.
Symmetric Information and Cooperation in It Project Success
Authors: de Oliveira Henrique Pontes Gonçalves , Albertin Alberto Luiz 
Published: May 2023

Abstract
With the advancement of technological solutions and the increasingly agile and competitive business context, Information Technology has played an essential role in organizations. As a result, the number of IT demands has significantly increased, which requires the use of project management practices. IT projects require high generation and flow of information and interaction between different areas, which demand proper, sensitive communication procedures associated with the success or failure of a project. This study investigated the effect of information symmetry and cooperative actions on project success. After an extensive bibliographic review, we elaborated three research propositions. Data collection was conducted in two large multinational companies, and a strategic project was qualitatively analyzed in each of them. Both projects found unsatisfactory results. Failures in the communication process, especially information asymmetry, were the main factors that produced unsatisfactory results. In addition, communication inefficiency directly impaired cooperative actions.
Direct interaction between marine cyanobacteria mediated by nanotubes
Authors: Angulo-Cánovas Elisa , Bartual Ana , López-Igual Rocío , Luque Ignacio , Radzinski Nikolai , Shilova Irina , Anjur-Dietrich Maya , García-Jurado Gema , Ubeda Barbara , Gonzalez-Reyes José Antonio , Díez Jesús , Chisholm Sallie , García-Fernández José Manuel , Muñoz-Marín María del Carmen 
Published: May 2023

Abstract
Numerous microbial associations and interactions drive and regulate nutrient fluxes in the ocean. Symbiotic interactions are the best example and are key drivers of ecological diversification and evolutionary innovation on Earth1. Besides symbiotic, other kinds of interactions exist between free-living bacteria; for example, the uptake of shared metabolites, horizontal gene transfer (HGT), quorum signaling, and exchange of substances via extracellular vesicles or pili2-5. Physical contact between cells of marine cyanobacteria had not been studied thus far. Here, we show a new mechanism of direct interaction between the marine cyanobacteria Prochlorococcus and Synechococcus, the intercellular membrane nanotubes (NTs).
We present evidence of inter- and intra-genus exchange of cytoplasmic material between neighboring and distant cells of cyanobacteria mediated by NTs. We visualized and measured these structures in axenic and in natural samples. We show that NTs are produced between living cells, suggesting this is a relevant communication system in vivo. The discovery of nanotubes acting as exchange bridges in the most abundant photosynthetic organisms in the ocean may have significant implications for the survival marine microbial interactions. The transfer of compounds between these small bacteria in areas with poor nutrient concentrations might be an important factor in their ecological success in the ocean ecosystems. Furthermore, nanotubes-mediated cell interaction provides additional evidence for the importance of cooperation between these marine cyanobacteria, showing they act as a collective rather than individual cells in the context of marine ecosystems.
Resource inequality and quality of secondary education: a study of uneven policy in rural schools of southwestern Nigeria
Authors: Okunlola John Olayemi , Hendricks Winston 
Published: May 2023

Recent Studies have investigated the influence of the resource factor on the quality of secondary education (QSE) in Nigeria. However, the research on the resource factor as a predictor of quality of secondary education in rural communities of Southwestern Nigeria remains scanty. This study, therefore, investigated the contributions of the resource factor (RF: Resource Adequacy-RA and Resource Utilization-RU) to QSE in rural communities of Southwestern Nigeria (RCSN). The study was located within a pragmatic paradigm that incorporated the convergent parallel design in the collection, analysis and interpretation of the qualitative and quantitative data. The multi-level mixed methods sampling technique was adopted in selecting 467 secondary school graduates, while total enumeration technique was adopted in selecting 134 teachers. Six participants for the Key Informant Interviews comprised three principals and three senior officials from the Teaching Service Commission and Ministry of Education from three selected states in southwestern Nigeria. Two research questions were raised, and one hypothesis was formulated for the study. Two research instruments, namely, the Secondary School Graduate Aptitude Test (SSGAT) and Resource Factor Teachers’ Questionnaire (RFTQ), with reliability coefficients of 0.715 and 0.853, respectively, were used for the study. Quantitative data were analyzed using descriptive statistics and Pearson Product Moment Correlation, while qualitative data were analyzed with content analysis. The resource factor with resource adequacy (x=2.50) and resource utilization (x=2.77) influenced QSE. The resource factor (r=0.75) had a negative significant relationship with QSE. The study affirmed that addressing resource inequality in rural communities is urgently required to stem the ebbing tide of quality secondary education in Nigeria.
Seasonal assessment of pupal habitat productivity of malaria vector: Anopheles gambiae s.l as influence by physico-chemical conditions at selected breeding habitats in Niger, Nigeria
Authors: Babale Shitta Kefas , Salim Hasber , Yakudima Ismaila Ibrahim , Kabir Buda Mohammed , Mamman Rashidu , Chiroma Usman Mohammed , Ibrahim Shehu Kura 
Published: May 2023

Malaria is the most significant protozoan disease in Africa and the principal vector-borne disease (VBD) in Nigeria, which is influenced by the quality of breeding habitats that are reflected through the stage preceding adult. Control of Anopheles gambiae s.l. populations through source reduction is still considered the most effective way of prevention and control, although it has proven unsustainable in Niger State. Physico-chemical cues were investigated. Samples were taken inside and outside 1m2 cages weekly by dipping and emptying the cages from May 2019 to March 2020. The data subjected to analysis of variance (one and two-way Anova). The findings revealed the mean pupae abundance (MPA), were significantly higher in Large Water bodies (624.50±217.81), and followed by Gutters (436.00±184.2) and Swamps (285.50±125.06). The mean pupae productivity (MPP), followed the order of descending rate >GT (717.50±219.38) >LW (677.21±145.10) >SW (530.40±136.97). The result also showed that emptying technique (ET) was more sufficient and reliable than dipping technique (DT). The peak abundance and productivity of the pupal stage was June to August then declined in March,2020 both habitats. However, MPP differed significantly (p<0.05) from one another across the months in all the habitat types. The physical and chemical cues of the breeding sites, varied significantly, except in temperature, total hardness, biochemical oxygen demands, conductivity, and pH in all the habitats. This study revealed high utilization of physico-chemical properties and poses increased risk of malaria. Thus, emphasis on the vector management strategies should be given specially on gutters and large water bodies as breeding habitats of malaria vectors (MV), in Niger State
Improvement of the manufacturing method of semi-finished fruit and vegetables of a high degree of readiness
Authors: Zahorulko Andrii , Zagorulko Aleksey , Postadzhiev Alexander , Ibaiev Eldar , Birchenko Nataliia , Tytarenko Nataliia 
Published: May 2023

The method of production of concentrated fruit and vegeTable semi-finished product based on apples, Jerusalem artichoke and quince has been improved. Selected components of plant raw materials are chosen due to the presence of such useful substances as pectins, vitamins, minerals, etc. The obtained semi-finished products of a high degree of readiness are semi-finished products with a natural nutrient composition. A feature of the proposed method is the use of low-temperature modes of concentration and drying of raw materials. For the developed method, the hardware set of the line with the use of advanced thermal equipment was selected. Chopped raw materials are blanched in a universal multifunctional device: apple and Jerusalem artichoke in a steam environment (103 °C and 108 °C) for 4 and 8 minutes. Quince is blanched under conditions of pre-exposure in a 0.1 % solution of citric acid in an aqueous medium at a temperature of 75...80 °C (4...8 min.).
Concentration to a pasty state takes place in the improved design of the rotary-film apparatus with a reduced processing time of 0.75...1.25 s to a DM content of 28...30 %. To obtain a powdery state, a cylindrical IR dryer was used for drying to the final moisture content at the level of 4...6 % DM. It is also possible to dry the extracts formed after wiping the raw materials to a final moisture content of 10...13 % DM in an IR dryer. The use of low-temperature regimes in the range of 45...60 oC helps to obtain high-quality semi-finished products with maximum preservation of the initial properties of raw materials. By means of organoleptic evaluation, the best experimental sample with the content of blend components was found: apple 40 %; Jerusalem artichoke 35 %; quince 25 %. Developed semi-finished products are additives or fillers in various food products to improve their nutritional value
Somos tres, cuatro o más (+): Hacia la construcción de vínculos sexuales libres
Authors: Gallo Botero Manuela , Fernández Arango Gloria Amparo , Correa Gallego Kelly Alejandra , Carmona Duque Paula Andrea , Montero Duque Yuri Vanessa , López Arboleda Gloria María 
Published: May 2023

La relación de pareja está permeada por un sinnúmero de significados que atraviesan las diferentes dinámicas sexuales y la formación de vínculos, en búsqueda de un sentido, desde tiempos inmemorables. El presente artículo pretende ofrecer un acercamiento a la comprensión de las nuevas dinámicas de vinculación sexual, en parejas estables de Latinoamérica, en el último decenio del siglo XXI. A partir de una revisión documental, el artículo muestra las nuevas formas del amor que han estado presentes en el tiempo, evidenciando que, aunque están inmersas en creencias, culturas y la misma sociedad, continúan siendo un tema tabú, acompañadas, además, de un gran vacío de información al respecto. El artículo comienza mostrando los tránsitos históricos de la sexualidad en pareja, pasando por la reflexión del vínculo afectivo romántico y sexual afectivo, para culminar con una disertación en torno a las diversas prácticas sexuales no monógamas. En definitiva, el artículo concluye con una invitación a entender la resignificación de la vida sexual en pareja, orientada a nuevas transformaciones, sentidos y novedosas formas de ver y experimentar el amor y la sexualidad.
Influence of land use changes on groundwater quality – Bafoussam, West Cameroon
Authors: Nguedia Kevin Djatsa , Ndongo Barthelémy , Ntankouo Njila Roger , Kagou Dongmo Armand 
Published: May 2023

Abstract

The purpose of this work was to show that the change in land use impacts the quality of free groundwater and therefore the health of the population in the city of Bafoussam. Land use was dominated by housing (about 42%) followed by agricultural areas (33%) and green space. The socio-economic diagnosis by the guided survey showed that 62.5% of the population consumes CAMWATER water with malaria as the dominant water-related disease. The collection of water samples analysed by the colorimetric and photometric assay has allowed us to obtain a dominant water facies of the chloride and sulphate–calcium–magnesium type. The mapping of areas potentially vulnerable to pollution by ArcGIS 10.8 software presents the low-lying areas, downstream of agricultural sites, close to industries and neighbourhoods with strong urban disorder as the most vulnerable to pollution and therefore retained as actors of diffuse groundwater pollution in the city of Bafoussam. Thus, the change in land use and the increase in agglomeration degrade the quality of groundwater in this city.
Impact of water–tourism–ecosystem nexus on the sustainable development of eco-city
Authors: Zhu Kun 
Published: May 2023

Abstract
Tourism places substantial stress on regional land use that can lead to ecological deterioration, greater pollution, destruction of natural habitats, and increasing threats to species already in danger of extermination. Improved quality of life is made possible through the Fuzzy Hamacher Correlated Geometric (FHCG) method to observe the growth of multiple attributes in a water-based leisure tourism eco-city. Geographic Information System (GIS) technology, land use maps, and an executive segment satellite image are the main areas of attention for eco-cities as the main focus, which are supported by ecology and environmental space. Hence, FHCG-GIS has designed an environmental carrying capacity in eco-cities that can be increased through tourists who can be accepted in a specific location to fulfill the needs of water tourism, help the destination sector, protect the environment, and reduce the effect. A sensible outcome for evaluating the planning conditions in an eco-city can be found in the estimated indicators of water leisure tourism environmental carrying capacity, predicated on an analysis of scenic geographical resources and tourism economic conditions, and the results of the scenic area's integrated limits using barrel extrapolation.
Collagenous Colitis associated with Celiac Disease
Authors: Malaeb Maher , Mahboub Sameera , Howeedy Aly 
Published: May 2023

Introduction:
Microscopic colitis is an inflammatory GI condition whereby patients present predominantly with chronic watery diarrhea associated with other non-specific symptoms such as abdominal pain, urgency, fecal incontinence, weight loss, arthralgia, myalgia, anxiety, depression, and fatigue, which negatively impact their quality of life.

Case Presentation:
We present a case of a 44 -year old female with a history of hypothyroidism and celiac disease who presented to the GI clinic with a history of more than ten diarrhea episodes per day along with mild abdominal pain and bloating.

Conclusion:
A colonoscopy was performed, and a random colon biopsy revealed collagenous/microscopic colitis.
Evaluating Gut Microbiota Modification as a Next-Generation Therapy
for Obesity and Diabetes
Authors: Hossain Md. Imran , Akash Sajidur Rahman , Faruk Md. Omor , Mimi Sanjida Islam , Chowdhury Imtiaj Hossain , Islam Md Shariful , Alam Md. Mahbubol , Ali Md. Sarafat 
Published: May 2023

Abstract:
The human body is a complex ecosystem that thrives on symbiosis. It is estimated that
around 10^14 commensal microorganisms inhabit the human body, with the gut microbiota being
one of the most diverse and complex populations of bacteria. This community is thought to comprise
over a thousand different species that play a crucial role in the development of critical human
diseases such as cancer, obesity, diabetes, mental depression, hypertension, and others. The gut
microbiota has been identified as one of the most recent contributors to these metabolic disorders.
With the emergence of inexpensive and high-performance sequence technology, our understanding
of the function of the intestinal microbiome in host metabolism regulation and the development of
(cardio) metabolic diseases has increased significantly. The symbiotic relationship between the gut
microbiota and the host is essential for properly developing the human metabolic system. However,
if this balance is disrupted by various factors such as infection, diet, exercise, sleep patterns, or
exposure to antibiotics, it can lead to the development of various diseases in the body, including
obesity and diabetes type 1 and 2. While many approaches and medications have been developed
globally to treat these diseases, none have proven to be entirely effective, and many show side effects.
Therefore, scientists believe that treating the gut microbiota using tried-and-true methods is
the best option for combating obesity and diabetes. In this study, we aim to identify several feasible
ways and prospects for gut microbiota therapy that can shape a new format for the treatment of
obesity and diabetes.
A Comprehensive Review of the Docking Studies of Chalcone for the
Development of Selective MAO-B Inhibitors
Authors: Krishna Athulya , Kumar Sunil , Sudevan Sachithra Thazhathuveedu , Singh Ashutosh Kumar , Pappachen Leena K. , Rangarajan T.M. , Abdelgawad Mohamed A. , Mathew Bijo 
Published: May 2023

Abstract:
Monoamine oxidase B is a crucial therapeutic target for neurodegenerative disorders like
Alzheimer's and Parkinson's since they assist in disintegrating neurotransmitters such as dopamine in
the brain. Pursuing efficacious monoamine oxidase B inhibitors is a hot topic, as contemporary
therapeutic interventions have many shortcomings. Currently available FDA-approved monoamine
oxidase inhibitors like safinamide, selegiline and rasagiline also have a variety of side effects like
depression and insomnia. In the quest for a potent monoamine oxidase B inhibitor, sizeable, diverse
chemical entities have been uncovered, including chalcones. Chalcone is a renowned structural
framework that has been intensively explored for its monoamine oxidase B inhibitory activity.The
structural resemblance of chalcone (1,3-diphenyl-2-propen-1-one) based compounds and 1,4-diphenyl-
2-butene, a recognized MAO-B inhibitor, accounts for their MAO-B inhibitory activity. Therefore,
multiple revisions to the chalcone scaffold have been attempted by the researchers to scrutinize the
implications of substitutions onthe molecule's potency. In this work, we outline the docking
investigation results of various chalcone analogues with monoamine oxidase B available in the
literature until now to understand the interaction modes and influence of substituents. Here we focused
on the interactions between reported chalcone derivatives and the active site of monoamine oxidase B
and the influence of substitutions on those interactions. Detailed images illustrating the interactions
and impact of the substituents or structural modifications on these interactions were used to support
the docking results.
Effects of COVID-19 Pandemic on the Mental Health of Women and
Treatment of Mental Disorders in the Unani System of Medicine: An
Overview
Authors: Ateeque Ahmed Sana Kauser , Sidra  , Sheema  , Jahan Nasreen , Ansari Abid Ali 
Published: May 2023

Background:
The world miserably collapsed when the COVID-19 (Coronavirus disease)
pandemic was going out of control. The ongoing crisis has damaging effects on the mental
health of individuals, predominantly women, in both developed and developing countries. Women
in developing countries, both as frontline workers and at home, are at increased risk of mental
health problems (specifically mental disorders). A few observational studies related to the COVID-
19 pandemic have reported a higher prevalence of mental health problems like stress, anxiety, depression,
insomnia, fear, delirium, hysteria etc. among women compared to men. Thus, understanding
the effects of the COVID-19 pandemic on women's mental health are as important to discuss
as their physical health effects.

Objective:
The Unani System of Medicine (USM) has a holistic approach to preventing, treating,
and curing mental disorders. The present article aimed to provide an overview of the effects of the
COVID-19 pandemic on women's mental health and its containment measures described in classical
Unani texts besides their relevance in the current outbreak.

Materials and Methods:
A manual literature survey of classical Unani literature such as Firdaus-
al-hikmat, Al Qanoon-fit-tib, Zakheera Khwarzam Shahi, and Kamilus Sana was conducted to
collect the information available on the strategic approaches of health promotion and disease prevention
in Unani Medicine. To obtain the appropriate English equivalent words for Unani terms
and the scientific name of the drugs, “Standard Unani Medical Terminology” and “Classification
of Unani Drugs” were consulted, respectively. Many pharmacological books and papers were considered
from PubMed, Google Scholar etc.

Results:
According to the literature review results, Unani doctors have pushed the adoption of personalised
and predictive methods for preserving health and preventing diseases. The main focus is
to treat the fragile population, i.e., women affected by mental illnesses.

Conclusion:
The present article emphasizes the mental health problems among women provoked
by the COVID-19 pandemic, their possible etiopathogenesis, prevention, and psychological, regimental
and pharmacological management of the USM.