bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical applicability of short form of Bruininks-Oseretsky Test of Motor Proficiency Second Edition in patients after treatment of acute lymphoblastic leukemia
Authors: Šnajdrová Tereza , Patrmanová Eliška , Jevič Filip , Bořilová Karolína , Hrdoušková Monika , Musálek Martin 
Published: April 2023

IntroductionAcute lymphoblastic leukaemia (ALL) ranks among paediatrics' most common oncological malignancies. Monitoring motor performance levels associated with self-sufficiency in the everyday activities of ALL patients is extremely important during treatment. The motor development of children and adolescents with ALL is most often assessed using the Bruininks-Oseretsky Test of Motor Proficiency Second Edition (BOT-2) complete form (CF) with 53 items or the short form (SF) with 14 items. However, there is no evidence in research that BOT-2 CF and SF give comparable results in the population of patients with ALL.ObjectiveThis study aimed to determine the compatibility of motor proficiency levels achieved from BOT-2 SF and BOT-2 CF in ALL survivors.Materials and MethodThe research sample consists of n = 37 participants (18 girls, 19 boys) aged 4–21 years (10.26, ± SD 3.9) after treatment for ALL. All participants passed BOT-2 CF and were at least 6 months and a maximum of 6 years from the last dose of vincristine (VCR). We used ANOVA with repeated measures, considering the sex, intra-class correlation (ICC) for uniformity between BOT-2 SF and BOT-2 CF scores and Receiving Operating Characteristic.ResultsBOT-2 SF and BOT-2 CF assess the same underlying construct, and BOT-2 SF and CF standard scores have good uniformity: ICC = 0.78 for boys and ICC = 0.76 for girls. However, results from ANOVA showed that the participants achieved a significantly lower standard score in SF (45.1 ± 7.9) compared to CF (49.1 ± 9.4) (p &lt; 0.001; Hays ω2 = 0.41). ALL patients performed the worst in Strength and Agility. According to the ROC analysis, BOT-2 SF obtains acceptable sensitivity (72.3%) and high specificity (91.9%) with high accuracy of 86.1%, and the fair value of the Area Under the Curve (AUC) = 0.734 CI95% (0.47–0.88) in comparison to BOT-2 CF.ConclusionsTo reduce the burden on ALL patients and their families, we recommend using BOT-2 SF instead of BOT-2 CF as a useful screening tool. BOT-SF can replicate motor proficiency with as high probability as BOT-2 CF but systematically underestimates motor proficiency.
The effect of extracorporeal membrane oxygenation on neurodevelopmental outcomes in children after repair of congenital heart disease: A pilot study from Turkey
Authors: Basgoze Serdar , Temur Bahar , Ozcan Zeynep Sila , Gokce Ibrahim , Guvenc Osman , Aydin Selim , Guzelmeric Fusun , Altan Kus Aylin , Erek Ersin 
Published: April 2023

BackgroundExtracorporeal membrane oxygenation (ECMO) is widely used after congenital heart surgery. The purpose of this study is to analyze the neurodevelopmental (ND) outcomes in patients who receivedECMO support after congenital cardiac surgery.MethodsBetween January 2014 and January 2021, 111 patients (5.8%) receivedECMO support after congenital heart operations, and 29 (26,1%) of these patients were discharged. Fifteen patients who met the inclusion criteria were included. A propensity score matching (PSM) analysis model was established using eight variables (age, weight, sex, Modified Aristotle Comprehensive Complexityscores, seizures, cardiopulmonary bypass duration, number of operations, and repair method) with 1:1 matching. According to the PSM model, 15 patients who underwent congenital heart operations were selected as the non-ECMO group. The Ages &amp; Stages Questionnaire Third Edition (ASQ-3) was used for ND screening;it includes communication, physical skills (gross and fine motor), problem-solving, and personal–social skills domains.ResultsThere were no statistically significant differences between the patients' preoperative and postoperative characteristics. All patients were followed up for a median of 29 months (9–56 months). The ASQ-3 results revealed that communication, fine motor, and personal–social skills assessments were not statistically different between the groups. Gross motor skills (40 vs. 60), problem-solving skills (40 vs. 50), and overall scores (200 vs. 250) were better in the non-ECMO patients (P = 0.01, P = 0.03, and P = 0.03, respectively). Nine patients (%60) in the ECMO group and 3 patients (%20) in the non-ECMO group were with neurodevelopmental delay (P = 0,03).ConclusionND delay may occur in congenital heart surgery patients who receivedECMO support. We recommend ND screening in all patients with congenital heart disease, especially those who receivedECMO support.
Predictive parameters and model for extubation outcome in pediatric patients
Authors: Charernjiratragul Kan , Saelim Kantara , Ruangnapa Kanokpan , Sirianansopa Kantisa , Prasertsan Pharsai , Anuntaseree Wanaporn 
Published: April 2023

BackgroundProlonged mechanical ventilation is associated with significant morbidity in critically ill pediatric patients. In addition, extubation failure and deteriorating respiratory status after extubation contribute to increased morbidity. Well-prepared weaning procedures and accurate identification of at-risk patients using multimodal ventilator parameters are warranted to improve patient outcomes. This study aimed to identify and assess the diagnostic accuracy of single parameters and to develop a model that can help predict extubation outcomes.Materials and methodsThis prospective observational study was conducted at a university hospital between January 2021 and April 2022. Patients aged 1 month to 15 years who were intubated for more than 12 h and deemed clinically ready for extubation were enrolled. A weaning process with a spontaneous breathing trial (SBT), with or without minimal setting, was employed. The ventilator and patient parameters during the weaning period at 0, 30, and 120 min and right before extubation were recorded and analyzed.ResultsA total of 188 eligible patients were extubated during the study. Of them, 45 (23.9%) patients required respiratory support escalation within 48 h. Of 45, 13 (6.9%) were reintubated. The predictors of respiratory support escalation consisted of a nonminimal-setting SBT [odds ratio (OR) 2.2 (1.1, 4.6), P = 0.03], &gt;3 ventilator days [OR 2.4 (1.2, 4.9), P = 0.02], occlusion pressure (P0.1) at 30 min ≥0.9 cmH2O [OR 2.3 (1.1, 4.9), P = 0.03], and exhaled tidal volume per kg at 120 min ≤8 ml/kg [OR 2.2 (1.1, 4.6), P = 0.03]; all of these predictors had an area under the curve (AUC) of 0.72. A predictive scoring system to determine the probability of respiratory support escalation was developed using a nomogram.ConclusionThe proposed predictive model, which integrated both patient and ventilator parameters, showed a modest performance level (AUC 0.72); however, it could facilitate the process of patient care.
High thermoelectric performance of TlInSe3 with ultra-low lattice thermal conductivity
Authors: Yin Xixi , Zhou Lang , Wang Qi , Liao Yangfang , Lv Bing 
Published: April 2023

Thermoelectric (TE) materials with an excellent thermoelectric figure of merit (ZT) provide an effective way to alleviate energy pressure and protect the environment. By applying the first-principles method, this paper makes a systematic study of the electronic and phonon transport properties of two-dimensional (2D) novel TlInSe3 utilizing the Boltzmann transport theory (BTE). The calculation results reveal that 2D TlInSe3 has an excellent power factor (0.81 × 10−2 W/mK2) and ultra-low lattice thermal conductivity (0.46 W/mK) at 300 K. We find that the low phonon group velocity and strong anharmonicity are the main factors leading to the ultra-low lattice thermal conductivity of TlInSe3. Meanwhile, by discussing the acoustic-optical scattering, we attribute low phonon group velocity and strong anharmonicity to the increase of scattering rates between acoustic mode and optical mode, which further suppresses the lattice thermal conductivity. In the analysis of electron and phonon transport properties, 2D TlInSe3, as a novel TE material, exhibits a ZT value as high as 4.15 at 500 K. Our research results show that TlInSe3 is a potential TE material, and the relevant analysis is significant in exploring new TE materials.
Analysis of metabolic differences in maize in different growth stages under nitrogen stress based on UPLC-QTOF-MS
Authors: Song Guipei , Lu Yanli , Wang Yuhong , Nie Caie , Xu Mengze , Wang Lei , Bai Youlu 
Published: April 2023

IntroductionMaize has a high demand for nitrogen during the growth period. The study of metabolic changes in maize can provide a theoretical basis for rational nitrogen nutrition regulation.MethodsIn order to investigate the changes of different metabolites and their metabolic pathways in maize leaves under nitrogen stress, we used ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) for metabolomic analysis of maize leaves under different nitrogen treatments at three critical growth stages (V4, V12 and R1) in a pot experiment under natural conditions.Results and discussionThe results showed that nitrogen stress significantly affected sugar metabolism and nitrogen metabolism, and affected carbon and nitrogen balance, and the effects of stress on maize leaves metabolism increased with the growth process. Metabolic pathways such as the TCA cycle and starch and sucrose metabolism were mainly affected at the seeding stage (V4). The stress response to nitrogen deficiency also showed significant upregulation of flavonoids such as luteolin and astragalin during the booting stage (V12) and anthesis-silking stage (R1). During R1 stage, the synthesis of tryptophan and phenylalanine and the degradation of lysine were significantly affected. Compared with nitrogen stress, the metabolic synthesis of key amino acids and jasmonic acid were intensified and the TCA cycle was promoted under nitrogen sufficiency conditions. This study initially revealed that the response mechanism of maize to nitrogen stress at the metabolic level.
Childhood trauma and violent behavior in adolescents are differentially related to cognitive-emotional deficits
Authors: Katembu Stephen , Zahedi Anoushiravan , Sommer Werner 
Published: April 2023

IntroductionConverging neurobiological and epidemiological evidence indicates that exposure to traumatic events in the early stages of development, that is, adverse childhood experiences (ACEs), negatively affects the likelihood of being involved in violent behavior later in life. These problems are hypothesized to be mediated by the disruption of executive functions, in particular, the ability to inhibit inappropriate actions. Here we aimed to distinguish the contribution of inhibition in non-emotional and emotional situations (i.e., emotion regulation) and assessed the modulating influence of stress, testing Nairobi county high school students in a two-experiment study.MethodsIn Experiment 1, neutral and emotional inhibition, working memory, and fluid intelligence were measured alongside questionnaires about ACE and violent behavior. Experiment 2 replicated these relations in an independent sample and assessed whether they would be aggravated after acute experimentally induced stress.ResultsExperiment 1 results showed that ACE was positively related to both non-emotional and emotional inhibition; in contrast, violent behavior was only associated with deficient emotional inhibition. Experiment 2 findings showed that stress did not significantly affect the relation of ACE to non-emotional inhibition and emotion regulation; however, it increased deficits of violent participants in their ability to down-regulate emotions.DiscussionTogether, results suggest that deficits in emotion regulation, especially under stressful conditions, are more critical than impairments in non-emotional inhibition in predicting violent behavior in victims of childhood trauma. These findings open perspectives toward more targeted research and interventions.
Sustainable volume sweep imaging lung teleultrasound in Peru: Public health perspectives from a new frontier in expanding access to imaging
Authors: Marini Thomas J. , Castaneda Benjamin , Satheesh Malavika , Zhao Yu T. , Reátegui-Rivera C. Mahony , Sifuentes Walter , Baran Timothy M. , Kaproth-Joslin Katherine A. , Ambrosini Robert , Rios-Mayhua Gloria , Dozier Ann M. 
Published: April 2023

BackgroundPulmonary disease is a common cause of morbidity and mortality, but the majority of the people in the world lack access to diagnostic imaging for its assessment. We conducted an implementation assessment of a potentially sustainable and cost-effective model for delivery of volume sweep imaging (VSI) lung teleultrasound in Peru. This model allows image acquisition by individuals without prior ultrasound experience after only a few hours of training.MethodsLung teleultrasound was implemented at 5 sites in rural Peru after a few hours of installation and staff training. Patients were offered free lung VSI teleultrasound examination for concerns of respiratory illness or research purposes. After ultrasound examination, patients were surveyed regarding their experience. Health staff and members of the implementation team also participated in separate interviews detailing their views of the teleultrasound system which were systematically analyzed for key themes.ResultsPatients and staff rated their experience with lung teleultrasound as overwhelmingly positive. The lung teleultrasound system was viewed as a potential way to improve access to imaging and the health of rural communities. Detailed interviews with the implementation team revealed obstacles to implementation important for consideration such as gaps in lung ultrasound understanding.ConclusionsLung VSI teleultrasound was successfully deployed to 5 health centers in rural Peru. Implementation assessment revealed enthusiasm for the system among members of the community along with important areas of consideration for future teleultrasound deployment. This system offers a potential means to increase access to imaging for pulmonary illness and improve the health of the global community.
The thoracolumbar interfascial block with local anesthesia in osteoporotic vertebral compression fractures treated with percutaneous kyphoplasty provides better analgesia compared with local anesthesia alone: A randomized controlled study
Authors: Tao Hong-lei , Zhang Hang , Jiang Yun-feng , Fan Shan-shan , Wang Hong-wei , Zheng Ao-te 
Published: April 2023

ObjectiveTo evaluate the safety and efficacy of the thoracolumbar interfascial block (TLIPB) in percutaneous kyphoplasty (PKP), and to confirm that the TLIPB further minimizes perioperative pain and residual back pain on the basis of local anesthesia.MethodFrom April 2021 to May 2022, 60 patients with osteoporotic vertebral compression fractures were included in this prospective randomized controlled trial. Patients were randomly assigned to a local anesthesia group (A group) or a TLIPB on the basis of local anesthesia group (A + TLIPB group) before PKP. Pain level (visual analog scale, VAS), amount of analgesic rescue drugs (parecoxib), operative time, mean arterial pressure, heart rate, and complications were assessed and compared between the two groups.ResultsCompared with the A group, VAS scores were lower in the A + TLIPB group, respectively, when the trocar punctured the vertebral body (7.4 ± 0.7 vs. 4.5 ± 0.9;P &lt; 0.01), during balloon dilatation (6.6 ± 0.9 vs. 4.6 ± 0.9;P &lt; 0.01), during bone cement injection (6.3 ± 0.6 vs. 4.3 ± 0.8;P &lt; 0.01), 1 h after surgery (3.5 ± 0.7 vs. 2.9 ± 0.7;P &lt; 0.01), and 24 h after surgery (2.5 ± 0.8 vs. 1.9 ± 0.4;P &lt; 0.01). Residual back pain (VAS: 1.9 ± 0.9 vs. 0.9 ± 0.8;P &lt; 0.01) and the incidence of rescue analgesic use (P = 0.02) in the A + TLIPB group were lower compared with the A group. Compared with the A group, mean arterial pressure and heart rate were lower in the A + TLIPB group when the trocar punctured the vertebral body, and with balloon dilatation and bone cement injection; however, there were no statistical differences between the groups 1 and 24 h after surgery. The incidences of bone cement leakage, constipation, and nausea were similar between the two groups. No patient developed infection, neurological injuries, constipation in either group.ConclusionThe addition of the TLIPB to local anesthesia can further minimize perioperative pain and residual back pain, and reduce perioperative rescue analgesic use. When added to local anesthesia, the TLIPB is an effective and safe anesthetic method for PKP.Clinical trial registrationThis study has been registered in the Clinical Trial registration: ChiCTR-2100044236.
Impact of neoadjuvant FLOT treatment of advanced gastric and gastroesophageal junction cancer following surgical therapy
Authors: Paszt Attila , Simonka Zsolt , Budai Krisztina , Horvath Zoltan , Erdos Marton , Vas Marton , Ottlakan Aurel , Nyari Tibor , Szepes Zoltan , Uhercsak Gabriella , Maraz Aniko , Torday Laszlo , Tiszlavicz Laszlo , Olah Judit , Lazar Gyorgy 
Published: April 2023

IntroductionTherapeutic treatment for advanced-stage (T2–T4) gastroesophageal junction (GEJ) and gastric cancer involves neoadjuvant chemotherapy with subsequent surgical intervention.MethodNeoadjuvant oncological treatment for GEJ and gastric cancer previously consisted of the intravenous administration of epirubicin, cisplatin and fluorouracil (ECF) or epirubicin, cisplatin and capecitabine (ECX) combination (Group 1). The new protocol (FLOT, F: 5-FU, L: leucovorin, O: oxaliplatin, T: docetaxel), included patients with resectable GEJ and gastric cancer who had a clinical stage cT2 or higher nodal positive cN+ disease (Group 2). Between 31 December 2008 and 31 October 2022, the effect of different oncological protocols in terms of surgical outcomes in cases of T2–T4 tumours were retrospectively evaluated. Results of randomly assigned patients from the earlier ECF/ECX protocol (n = 36) (Group 1) and the new FLOT protocol (n = 52) (Group 2) were compared. Effect of different neoadjuvant therapies on tumour regression, types of possible side effects, type of surgery, and oncological radicality of surgical procedures were analysed.ResultsWhen comparing the two groups, we found that in case of the FLOT neoadjuvant chemotherapy (Group 2, n = 52), complete regression was achieved in 13.95% of patients, whereas in the case of ECF/ECX (Group 1, n = 36), complete regression occurred in only 9.10% of patients. Furthermore, in the FLOT group, the mean number of lymph nodes removed was slightly higher (24.69 vs. 20.13 in the ECF/ECX group). In terms of the safety resection margin (proximal), no significant difference was found between the two treatment groups. Nausea and vomiting were the most common side effects. The occurrence of diarrhea was significantly higher in the FLOT group (p = 0.006). Leukopenia and nausea occurred more commonly with the old protocol (Group 1). The rate of neutropenia was lower following FLOT treatment (p = 0.294), with the lack of grade II and III cases. Anaemia occured at a significantly higher rate (p = 0.036) after the ECF/ECX protocol.ConclusionsAs a result of the FLOT neoadjuvant oncological protocol for advanced gastro-esophageal junction and gastric cancer, the rate of complete tumour regression increased significantly. The rate of side effects was also appreciably lower following the FLOT protocol. These results strongly suggest a significant advantage of the FLOT neoadjuvant treatment used before surgery.
Clinical outcomes, MRI evaluation and predictive factors of indirect decompression with lateral transpsoas approach for lumbar interbody fusion: a multicenter experience
Authors: Petrone Salvatore , Ajello Marco , Marengo Nicola , Bozzaro Marco , Pesaresi Alessandro , Allevi Mario , Fiumefreddo Alessandro , Denegri Federica , Cogoni Maurizio , Garnero Andrea , Tartara Fulvio , Di Perna Giuseppe , Armocida Daniele , Pesce Alessandro , Frati Alessandro , Zenga Francesco , Garbossa Diego , Cofano Fabio 
Published: April 2023

IntroductionEvaluating the effects of indirect decompression obtained through lateral lumbar interbody fusion (LLIF) by clinical improvements and radiological parameters on MRI scans. Identifying predictors of better decompression and clinical outcome.Materials and methodsFrom 2016 to 2019, patients who underwent single- or double-level indirect decompression LLIF were consecutively reviewed. Radiological signs of indirect decompression were evaluated in preoperative and follow-up MRI studies and were subsequently correlated to clinical data, expressed as axial/radicular pain (VAS back/leg), index of disability (Oswestry Disability Index) and clinical severity of lumbar stenosis (Swiss Spinal Stenosis Questionnaire).Results72 patients were enrolled. The mean follow-up was 24 months. Differences in vertebral canal area (p &lt; 0.001), height of the foramina (p &lt; 0.001), thickness of the yellow ligament (p = 0.001) and anterior height of the interbody space (p = 0.02) were observed. Older age (p = 0.042), presence of spondylolisthesis (p = 0.042), presence of intra-articular facet effusion (p = 0.003) and posterior height of the implanted cage (p = 0.020) positively affected the increase of the canal area. Change in root canal area (p &lt; 0.001), height of the implanted cage (p = 0.020) and younger age (p = 0.035) were predictive factors of root pain relief, while increased vertebral canal area (p = 0.020) and height of the interbody fusion cage (p = 0.023) positively affected the severity of clinical stenosis.ConclusionsLLIF indirect decompression showed both clinical and radiological improvements. Presence and degree of spondylolisthesis, presence of intra-articular facet effusion, age of the patient and height of the cage were predictive factors of major clinical improvements.
Synthesis of 5-Fluorouracil Polymer Conjugate and 19F NMR Analysis of Drug Release for MRI Monitoring
Authors: Alhaidari Laila M. , Spain Sebastian G. 
Published: April 2023

To monitor the release of fluorinated drugs from polymeric carriers, a novel 19F MRI enzyme-responsive contrast agent was developed and tested. This contrast agent was prepared by conjugation of 5-fluorouracil (5-FU) to hyperbranched poly(N,N-dimethylacrylamide) (HB-PDMA) via an enzyme-degradable peptide linker. Due to the different molecular sizes, the release of 5-FU from the 5-FU polymer conjugate resulted in a sufficiently substantial difference in spin-spin T2 19F NMR/MRI relaxation time that enabled differentiating between attached and released drug states. The 5-FU polymer conjugate exhibited a broad signal and short T2 relaxation time under 19F NMR analysis. Incubation with the enzyme induced the release of 5-FU, accompanied by an extension of T2 relaxation times and an enhancement in the 19F MRI signal. This approach is promising for application in the convenient monitoring of 5-FU drug release and can be used to monitor the release of other fluorinated drugs.
Redécouverte de Schistostega pennata (Hedwig) F. Weber et D. Mohr (Schistostegaceae, Bryophyta) dans le massif du Pilat (Loire, France)
Authors: Christians Jean-François 
Published: April 2023

La redécouverte d’anciennes localités de Schistostega pennata dans le
Parc naturel régional du Pilat est consécutive à des prospections ciblées, menées dans le cadre d’une enquête participative initiée par Isabelle Charissou sur le site «Bryophytes de France », également relayée par la Société Botanique du Centre-Ouest et par l’Amicale Legendre des Botanistes du Limousin. À cette occasion, de nouvelles stations ont également pu être mises en évidence. La biologie et l’écologie de cette mousse sont présentées, puis seront précisées ses répartitions ancienne et actuelle pour le massif du Pilat.