bluuebunny/crossref_metadata_2025_split huggingface dataset:
E-Vehicle Design Health Review System
Authors: Arnab Arnab Dasgupta , Rahul Rahul Kumar , Bivas Bivas Bhattacharyya , Ankit Ankit Mehta 
Published: February 2023

Abstract
There are a number of methodologies & approaches manufacturers and R&D Units can adopt to meet the desired Design & BOM (Bill of material) accuracy, but the most optimized & promising is developing a seamless digital platform (application) that caters to both Design and BOM (Bill of Material) review & its respective defects resolution and monitoring parallely. Considering complex products & large no. of new product introduction due to competitive market scenario, how do original equipment manufacturers, production and R&D firms determine the best way forward?
Product Development team has developed an Innovative zero defect methodology that provides a platform for design review & its defects (Issues) closure mechanism simultaneously. This approach enables manufacturers to effectively handle complex design reviews, cost optimization, complexity reduction, BOM-Cost management & maintaining the intended product accuracy there by enabling faster product launch & time to market at competitive price. On top of it, it enables automated system based computation at each defined critical stage to concerned stakeholders for required action thus reducing manual intervention & time consumption. Integration of multiple system for automated reports generation and live dashboard for monitoring of part development and availability status. Predictive Analysis reports enlisting critical parts to take early development actions or providing alternate suggestions in order to meet the project delivery timeline.
This paper discusses the in-depth process & stages of ‘E-VDHRS’ to effectively handle complex models/Products market introduction & benefits of this application in comparison to conventional approach along with in-sights of digital utilities & databases created in application to facilitate end-user with intended design review, cost optimize, Critical Issue management, defect reduction & accuracy achieved using this Innovative zero defect methodology. This robust system delivers a set of solutions that enabled process & productivity improvements via. Digital transformation resulting in drastically improved key levers like ‘Product design quality’, ‘Product launch timeline’, ‘BOM-Cost optimizations’ & ‘part complexity reductions’.
The Particle Swarm Multi-subspace Augmentation Optimization
Authors: Donkor Derrick 
Published: February 2023

Abstract
In this article, the proposed Particle Swarm Optimization (PSO) variant uses a search space with distinct subspaces for each particle in the population respectively in the exploration of the optimum solution. What is normally done for a reduction in swarm size and achieving a much quicker response in PSO is to manually set the swarm size and other auxiliary constants through trial and error. An algorithm is proposed which assigns a particle to a discrete subspace and combines each particles position to form the solution at every functional evaluation. This assignment of the particle to a discrete subspace is suitable for swarm size reduction and quick convergence with less iteration. The theoretical basis is provided for the proposed algorithm and empirical studies are conducted to compare the proposed algorithm with PSO and some selected optimization algorithms on reference benchmark test functions. Based on the experimental results, the proposed algorithm has a higher accuracy than the other optimization algorithms.
Evaluation of variants in the ENTPD1 (g.209A&gt;G, g.291A&gt;T e g.338G&gt;A) and ENTPD2 (g.464G&gt;A) genes in athletic horses with exercise-induced pulmonary haemorrhage
Authors: Leite Raíssa , Albertino Lukas Garrido , Campos Fernanda , Campos Reinaldo , Borges Alexandre , Oliveira-Filho Jose 
Published: February 2023

Abstract

Background
Exercise-induced pulmonary haemorrhage (EIPH) is characterized by the presence of blood from the lungs in the tracheobronchial tree after intense exercise in athletic horses. Despite the high prevalence of EIPH in horses, the primary aetiology remains unknown. Mutations in genes encoding CD39 and CD39L1 (ENTPD1 and ENTPD2, respectively) were previously reported as potential genetic causes involved in EIPH pathogenesis. However, the role these mutations associated with haemostatic functions is unknown.
Results
To investigate the association between EIPH and mutations (g.290A > G, g.291A > T, and g.338G > A) in the ENTPD1 and (g.646G > A) ENTPD2 genes, 76 Thoroughbred horses diagnosed with EIPH and 56 without clinical signs of EIPH (control group) by trachea-bronchial endoscopy were genotyped. The g.290A > G and g.338G > A mutations were linked, explaining why the same results were found in all horses. Both of these mutations were observed in 56.6% of homozygous and 39.5% of heterozygous EIPH horses. In the control group, 66.1% and 28.6% of horses were homozygous and heterozygous for these mutations, respectively. Approximately 2.6% (2/76) of EIPH horses and no control horses (0/56) were homozygous for the g.291A > T mutation. Meanwhile, in the EIPH group, there were 1.5% (1/68) homozygotes and 23.5% (16/58) heterozygotes for the g.464G > A mutation. In the control group, this mutation was observed only in heterozygotes (15.6%, 7/45). There was no significant difference between groups for any of the mutations.
Conclusions
The mutations previously described in the genes encoding CD39 and CD39L1 enzymes are highly present in the studied population. A possible breed predisposition may be involved; however, no association was found between the occurrence of EIPH and the presence of these mutations in the ENTPD1 and ENTPD2 genes in Thoroughbred horses in this study.
Incidence of blunt cerebrovascular injury (BCVI) in pediatric hangings and recommendation for screening
Authors: Golubkova Alena , Liebe Heather , Leiva Tyler , Stewart Kenneth , Sarwar Zoona , Hunter Catherine J. , Johnson Jeremy J. 
Published: February 2023

Abstract
Purpose
Incidence of blunt cerebrovascular injury (BCVI) following hanging in the pediatric population is ill-defined. Current guidelines recommend screening imaging during the initial trauma evaluation. Necessity of screening is questioned given BCVI is considered rare after hanging, especially when asymptomatic. This study aims to elucidate the incidence of BCVI in pediatric hangings and determine the value of radiographic work up.
Methods
A retrospective cohort study was performed, of pediatric hangings reported to the National Trauma Databank (NTDB), 2017–2019. Imaging, diagnoses, and findings suggestive of BCVI, such as Glasgow Coma Scale (GCS) ≤ 8, presence of cervical injury, and soft tissue injury were considered. Statistical analysis was carried out to compare incidence.
Results
197 patients met study criteria, with 179 showing up to the trauma bay with signs of life. BCVI incidence was 5.6% (10 of 179). A CT angiogram (CTA) was completed in 46% of the patients.
Conclusion
BCVI incidence following pediatric hanging is more common than previously thought. Less than half of patients had a CTA reported in this cohort. This may result in an underestimate. Given the potentially devastating consequences of a missed BCVI, the addition of CTA to initial work up is worthwhile to evaluate for cervical vascular injury.
Effect of water temperature on internal nitrogen release from sediments in the Pearl River Delta region, China
Authors: Zhu Dantong , Cheng Xiangju , Sample David J. , Qiao Qingsong , Liu Zhaowei 
Published: February 2023

Abstract
Nitrogen (N) has received attention as an indicator of water quality and pollution. However, the N content of rivers, lakes, and reservoirs varies significantly by season, and environmental factors such as temperature affect it. An experiment was conducted with a series of tanks containing sediments from the Pearl River Delta region of China and distilled water to assess the release of N from sediments under controlled conditions; temperatures from 10 to 30℃ were assessed. Results show that the effect of temperature on N in the water column and sediment is nonlinear. Only temperatures ranging from 20 ~ 25℃ affected NO3-N in shallow sediments. Temperatures lower than 20℃ had more effect on NH4-N concentration in the water column, while NO3-N concentration was affected heavily at higher temperatures. NH4-N typically is stable at a relatively high concentration in the water column at 20℃. While NO2-N is stable in the water column at higher temperatures, NO3-N is the dominant form of N in water bodies at temperatures from 25℃ to 30℃. At 20℃, dissolved inorganic nitrogen was released from the sediment to the water column, gradually reaching equilibrium. Temperature could affect the internal release of NH4-N; this process gradually accelerated as the temperature rose. However, the presence of NH4-N in a water body can inhibit its release, thus the relationship between the diffusive flux with temperature is not linear. The relationship between N diffusive flux at the sediment-water interface can be described by Polynomial2D and Lorentz2D models (R2 > 0.87).
Baclofen treatment prevents persistent working memory deficits induced by alcohol withdrawal through restoration of histone H3 methylation in mice
Authors: De Clerck Mael , Manguin Martin , Dalmeida Marion , Beracochea Daniel , Mons Nicole 
Published: February 2023

Abstract
Epigenetic modifications have emerged as key contributors to the enduring behavioral and molecular neuroadaptations following withdrawal from chronic alcohol exposure. Here, we investigated in C57/BL mice whether repeated daily injections of baclofen, a γ-aminobutyric acid (GABA) type B receptor (GABAB-R) agonist, administrated during the withdrawal period could prevent deficits in working memory and associated changes of the transcriptionally repressive mark dimethylated histone H3 lysine 9 (H3K9me2) in the dorsal hippocampus and the prefrontal cortex. We found that mice subjected to a 4-week withdrawal period after 5 months of alcohol consumption exhibit persistent deficits in spatial working memory and abnormal decreases in global levels of H3K9me2 immunoreactivity in both regions. Importantly, baclofen treatment during the 15 days preceding the end of alcohol withdrawal reversed working memory impairments and led to full reversal of the withdrawal-induced decreased levels of H3K9me2 in both regions. In addition, baclofen also reversed the withdrawal-induced aberrant decrease of permissive histone H3 lysine 9 acetylation (H3K9ac) in the dorsal hippocampus. Conversely, administration of UNC0642, a pharmacological inhibitor of the lysine methyltransferase G9a-mediated H3K9me2, prior to testing blocked the preventive effect of baclofen on withdrawal-induced working memory impairment. Together, these results suggested that, after prolonged alcohol withdrawal, downregulation of GABAB-R function may mediate long-lasting working memory impairment via downregulation of H3K9me2 and G9a activity in the dorsal hippocampus and prefrontal cortex.
Planning of Distributed Generation Resources to Simultaneously Improve Reliability and Resilience of Distribution Network
Authors: Ghanbarimasir Vali , Yousefi Borzou , Noori Abdoreza , Rezvani Mohammad 
Published: February 2023

Abstract

In this paper, a novel optimization framework is proposed for the assessment of distribution network reliability and resilience via distributed generation (DG) placement. In this regard, a stochastic multi-objective optimization model is introduced that utilizes optimal allocation of DG units along with an optimal service restoration strategy by using the network’s embedded remote-control switches. The model minimizes distribution network outage costs due to both reliability contingencies and resilience events while keeping DG investment costs minimum. The optimal service restoration problem is formulated as a mixed-integer linear programming (MILP) model that satisfies network technical constraints. In order to capture the uncertain nature of fault contingencies, two different scenario sets are generated. Historical data of the network’s fault-rates, and the failure probability functions of network components obtained from Monte Carlo simulation (MSC), are used for reliability and resilience scenarios, respectively. The non-dominated sorting genetic algorithm (NSGA-II) approach is applied to solve the model which provides a Pareto-optimum solution pool. A fuzzy decision-making logic tool is then applied to assist the network planners in opting the final solution from the Pareto-front. The proposed model is tested on IEEE 33-bus system and the simulation results show the effectiveness of the model.
Coronary microvascular dysfunction and myocardial area at risk assessed by CZT-SPECT after primary PCI in AMI patients
Authors: Cui Lijun , Zhang Kun , Wangyang Chongzi , Chen Weiqiang , Huang Ping , Song Zhenguo , Tian Gang , Yu Pengwei , Tang Zijian , Wang Jiao , Li Jianming , Tse Gary , Liu Tong , Wang Yongde , Chen Kangyin 
Published: February 2023

Abstract
Purpose
This study used CZT-SPECT to evaluate the prevalence and characteristics of coronary microvascular dysfunction (CMD) and myocardial area at risk (AAR) in acute myocardial infarction (AMI) patients who received primary percutaneous coronary intervention (PCI).
Methods
This was a single-center cross-sectional retrospective study. 83 patients received primary PCI for acute myocardial infarction. Subsequently, a rest/stress dynamic and routine gated myocardial perfusion imaging one week after PCI. The CMD group was defined as: the residual stenosis of infarct-related artery (IRA) < 50% and myocardial Flow Reserve (MFR) < 2.0 in this corresponding territory; While MFR ≥ 2.0 of IRA pertained to the normal control group.
Results
A total of 53 patients with a mean age of 57.06 ± 11.99 years were recruited, of whom 81.1% were STEMI. The proportion of patients with CMD was 79.2% (42/53). The time of pain to SPECT imaging was 7.50 ± 1.27 days in CMD group and 7.45 ± 1.86 days in controls. CMD patients had a higher body mass index (BMI) than controls (26.48 ± 3.26 vs 24.36 ± 2.73, P < 0.05), and a higher proportion of STEMI, TIMI 0 grade of infarct relate artery (IRA) prior PCI than controls (88.1% vs 54.5%, 61.9% vs 18.2% respectively) (all P < 0.05). No significant difference was identified in the rest-myocardial blood flow (MBF) of IRA between the two groups, whereas the stress-MBF and MFR of IRA, Rest-AAR, Stress-AAR in the CMD group were remarkably lowered (P < 0.01). Higher BMI (OR:1.332, 95%CI:1.008–1.760) and Stress-AAR (OR:1.994, 95%CI:1.122–3.543) were used as independent predictors of CMD occurrence (P < 0.05).
Conclusions
The prevalence of CMD is high in AMI patients who received primary PCI. Each 1kg/m2 increase in BMI was associated with a 1.3-fold increase in CMD risk. A 5% increase in Stress-AAR was associated with a nearly 2-fold increase in CMD risk. Increased BMI and stress-AAR predicts decreased coronary reserve function.
Alternatives to animal-source foods are key to reaching climate goals
Authors: Hale Galina , Onescu Vlad , Bhangale Ritesh 
Published: February 2023

Abstract
The global food system is an important contributor to greenhouse gas emissions that are responsible for climate change. Animal agriculture is responsible for a large share of the food-
system emissions, both directly and through the production of animal feed.(1) Limiting global warming to the goals set forth by the international community will not be possible without
rapid phasing out of animal-source food.(2)(3) Given population growth, is there a path for food system development that can be consistent with global demand for calories and protein
without jeopardizing climate goals? Here we show that the rapid adoption of alternatives to animal-source foods, such as plant-based, cultured, or fermentation-derived, is consistent with
climate goals, especially when combined with the transition to healthier diets and agricultural yield improvements.(4) Alternatives must achieve parity with animal-source foods, which means matching their price, taste, and other attributes. Delaying the introduction of alternatives at parity, even by a few years, makes a big difference in total greenhouse gas emissions from the food industry. To our knowledge, this is the first study to quantify greenhouse gas emissions across a variety of scenarios involving the transition from animal-source foods to alternatives in a global context and across all food groups. Moreover, we carefully model the transition to alternatives using conventional product adoption modeling. Our results point to the urgent need for large-scale acceleration of innovation in alternatives to animal-source food to achieve parity as soon as possible in order to allow for rapid adoption of such alternatives in time to limit global warming to 1.5 degrees C by 2100 with a 66% probability. For such acceleration,
policy interventions analogous to those provided for alternative energy are needed to create innovation-friendly environment
Climate adaptation and WASH behavior change in the Lake Victoria Basin
Authors: Marcus Hannah , Muga Raphine , Hodgins Stephen 
Published: February 2023

AbstractAs climate change disrupts the global hydrological cycle, bringing extremes of flooding and drought, many communities will experience changes in water and sanitation quality and access, requiring adaptive behavior changes. This study set out to map the adaptation patterns – namely, the strategies employed to cope with water, sanitation, and hygiene (WASH)-related impacts of climate change – within the Mabinju community, located along the banks of Lake Victoria in Western Kenya. Qualitative methods were employed, involving 17 semi-structured individual interviews and seven focus groups with village members. Insights derived from direct conversations with village members were deepened through qualitative interviews with an additional 13 WASH sector stakeholders working in the wider Lake Victoria Basin region. Through this study, various WASH-specific community adaptation measures were identified, with both positive and negative impacts on long-term local climate resilience. While many positive coping strategies were found to be spurred by the creative faculties of local residents, capacities for adaptation were found to be restrained by broader forces of poverty and resource access, resulting in the adoption of certain maladaptive coping mechanisms. These findings highlight the need for climate adaptation interventions in the WASH sector to simultaneously build on existing resilience-enhancing measures while addressing the root causes of maladaptation.
Toxicity of sediments in eight urban stormwater management ponds: bioassessment by oligochaete community metrics used in the sediment quality triad
Authors: Tixier Guillaume , Rochfort Quintin , Grapentine Lee , Marsalek Jiri , Lafont Michel , Vivien Régis 
Published: February 2023

ABSTRACT

Implemented for decades as part of the ‘best management practices (BMPs)’ for controlling urban runoff impacts on receiving waters, stormwater management ponds (SMPs) have been increasingly viewed as potential habitats for urban wildlife. However, since SMPs are subject to a lot of environmental constraints, research toward assessing their ecological quality and their actual benefits as habitats for biota is needed. In this study, the sediment toxicity of eight SMPs located in Southern Ontario, Canada was assessed using the sediment quality triad (SQT) approach. Sediment samples were collected for chemical, ecotoxicological and biological analyses. An oligochaete-based index approach (Oligochaete Index of Lake Bioindication and percentage of pollution-sensitive species) was used as the biological endpoint and integrated into a weight-of-evidence approach to assessing the general sediment quality of the ponds. Our results showed that (i) heavy metals in the sediment and (ii) chloride concentrations in the sediment interstitial water caused detrimental effects on the ecological quality of the sediments in the ponds studied. The oligochaete indices applied in this study showed value as biological endpoints to be integrated into the SQT and used for setting up sediment ecological quality goals.
Chalcone Derivatives as Antibacterial Agents: An Updated Overview
Authors: de Oliveira Aldo S. , Cenci Arthur R. , Gonçalves Lucas , Thedy Maria Eduarda C. , Justino Angelica , Braga Antônio L. , Meier Lidiane 
Published: February 2023

Background:
The indiscriminate use of antibiotics brings an alarming reality:
in 2050, bacterial resistance could be the main cause of death in the world, resulting in the
death of 10 million people, according to the World Health Organization (WHO). In this
sense, to combat bacterial resistance, several natural substances, including chalcones, have
been described in relation to antibacterial, representing a potential tool for the discovery
of new antibacterial drugs.

Objective:
The objective of this study is to perform a bibliographic survey and discuss the
main contributions in the literature about the antibacterial potential of chalcones in the last
5 years.

Methods:
A search was carried out in the main repositories, for which the publications of
the last 5 years were investigated and discussed. Unprecedented in this review, in addition
to the bibliographic survey, molecular docking studies were carried out to exemplify the
applicability of using one of the molecular targets for the design of new entities with antibacterial
activity.

Results:
In the last 5 years, antibacterial activities were reported for several types of chalcones,
for which activities were observed for both gram-positive and gram-negative bacteria
with high potency, including MIC values in the nanomolar range. Molecular docking
simulations demonstrated important intermolecular interactions between chalcones and
residues from the enzymatic cavity of the enzyme DNA gyrase, one of the validated molecular
targets in the development of new antibacterial agents.

Conclusion:
The data presented demonstrate the potential of using chalcones in drug development
programs with antibacterial properties, which may be useful to combat resistance,
a worldwide public health problem.
miRNA as Drug: Antagomir and Beyond
Authors: Cannataro Roberto , Cione Erika 
Published: February 2023

Abstract:
MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing
20 to 25 nucleotides, present in all body fluids; they can be used as biomarkers, but much more
than this as a therapy to replace missing protein or to downregulate excess or aberrant synthesis;
here we report possible insight to future studies, needed in this exciting field.
The Journey of iPSC-derived OPCs in Demyelinating Disorders: From
In vitro Generation to In vivo Transplantation
Authors: Lohrasbi Fatemeh , Ghasemi-Kasman Maryam , Soghli Negar , Ghazvini Sobhan , Vaziri Zahra , Abdi Sadaf , Darban Yasaman Mahdizadeh 
Published: February 2023

Abstract:
Loss of myelination is common among neurological diseases. It causes significant disability,
even death, if it is not treated instantly. Different mechanisms involve the pathophysiology of demyelinating
diseases, such as genetic background, infectious, and autoimmune inflammation. Recently,
regenerative medicine and stem cell therapy have shown to be promising for the treatment of demyelinating
disorders. Stem cells, including embryonic stem cells (ESCs), induced pluripotent stem
cells (iPSCs), and adult stem cells (ASCs), can differentiate into oligodendrocyte progenitor cells
(OPCs), which may convert to oligodendrocytes (OLs) and recover myelination. IPSCs provide an
endless source for OPCs generation. However, the restricted capacity of proliferation, differentiation,
migration, and myelination of iPSC-derived OPCs is a notable gap for future studies. In this article, we
have first reviewed stem cell therapy in demyelinating diseases. Secondly, methods of different protocols
have been discussed among in vitro and in vivo studies on iPSC-derived OPCs to contrast OPCs’
transplantation efficacy. Lastly, we have reviewed the results of iPSCs-derived OLs production in each
demyelination model.