bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Hepcidin and C Reactive Proteins as Predictive Markers for Post Acne Scarring
Authors: Ahmed Sahar El-Sayed , Seoudy Wael Mohamed , Elhusseiny Rania Mahmoud , Saber Nesma Ibrahem 
Published: August 2023

Abstract

Background
Acne vulgaris is a common inflammatory skin condition affecting a large section of population. Hepcidin, a small peptide produced by the liver, is a recently discovered key regulator of iron homeostasis that was classified as a typeII acute phase protein. The synthesis of hepcidin is greatly stimulated by inflammation or by iron overload. C‑reactive protein (CRP) is one of the best indicators of systemic inflammation, considering that its serum levels show no circadian change across the 24 hrs. IL‑1, IL‑6 and TNF‑α that are found in the acne lesions are also major inducers of CRP production by the liver. Thus, CRP levels could be elevated in acne if the amount of local inflammation is high enough.

Aim of the Work
To measure serum Hepcidin and C reactive proteins in acne vulgaris patients & assess their ability as predictive serum markers for postacne scarring.

Patients and Methods
This Observational Cross sectional study, was carried out on 60 moderate, severe & very severe acne patients aged from 16 to 40 years old (with and without postacne scarring), recruited from the outpatient clinics of Dermatology, Venereology & Andrology departments of Ain-Shams University and MUST university Hospitals, from February 2019 toFebruary 2020.

Results
Levels of serum hepcidin protein of studied acne pateints were higher than normal range, while CRP serum levels were almost within normal range. Besides, Pateints with post acne scars had significantly lower serum hepcidin levels and higher CRP levels than pateints without. Furthermore, there was highly significant negative correlation between Hepcidin protein serum levels and duration and grade of acne, as well as post acne scarring grade. However, there was highly significant positive correlation between CRP serum levels and duration and grade of acne, as well as post acne scarring grade.

Conclusion
Serum hepcidin and CRP levels may provide an objective tool to predict the clinical outcome of acne vulgaris lesions and might help in determining the susceptible patients for scarring thus, configuring the therapeutic plan to start an aggressive treatment in patients prone to scar formation regardless of the clinical severity of acne vulgaris itself.
Evaluation of Serum Level of Interleukin 15 in Active Vitiligo Compared to Stable Disease and Healthy Control
Authors: Elfakkar Nehal Mohamed Zu , Karaly Rana Mohamed Desoky , Abdallah Mahmoud Mohamed Abdelreheem 
Published: August 2023

Abstract

Background
Vitiligo is a common acquired disorder of depigmentation. Its pathogenesis entails a T helper (TH) 1-cytotoxic T (CT) lymphocytes mediated autoimmune melanocyte destruction. Interleukin (IL)-15 is one of the IL-2 family of cytokines and shares several actions with IL-2. IL-15 enhances survival, maturation, and functional activity of natural killer, neutrophils, and dendritic cells. Furthermore, it potentiates survival, maturation, and cytotoxicity of memory CT cells. IL-15 has been shown to play a crucial role in the pathogenesis of several autoimmune diseases but was poorly investigated in patients with vitiligo.

Aims
To investigate the role of IL-15 in the pathogenesis of vitiligo.

Patients and Methods
In total, 40 Patients with vitiligo and 20 controls matched for age and gender were enrolled in the study. Vitiligo Extent Score (VES) and Vitiligo Disease Activity (VIDA) score were used to assess vitiligo severity and activity, respectively. Serum level of IL-15 was assessed by enzyme-linked immune-sorbent assay.

Results
Serum IL-15 level, in patients with vitiligo, was significantly higher in comparison with the control group (P =. 001). A significant positive correlation was found between serum IL-15 level and VES score (P =. 001)

Conclusion
IL-15 level was elevated in the sera of patients with vitiligo. IL-15 may therefore have a significant impact on vitiligo autoimmune pathogenesis, and further identification of its molecular roles may highlight new therapeutic strategies for vitiligo.
Evaluation of Serum Visfatin Level and Its Relation to Insulin Resistance in Patients with Inflammatory Acne Vulgaris
Authors: Hassan Sara Ashraf Ali , Soltan Marwa Yassin , Fattah Nermeen Samy Abdel 
Published: August 2023

Abstract

Acne vulgaris is a multifactorial pilosebaceous unit disorder, with histological, immunological and evidence suggesting inflammatory involvement in its different stages. Acne vulgaris possess psychological impact on affected patients due to facial disfigurement especially if severe. Visfatin is an adipokine of proinflammatory characteristics. It was related to insulin resistance, obesity and some inflammatory skin diseases.

Aim of the Study
The current study aimed to evaluate serum visfatin levels in inflammatory acne vulgaris patients and to reveal the possible relation between its serum levels and the insulin resistance status in patients.

Patients and Methods
The study included 30 patients suffering from inflammatory acne vulgaris and 30 healthy control subjects. Full general and dermatological examination were performed, recording of BMI, GAGS score was done. Then, measurement of fasting insulin and fasting glucose was performed to calculate HOMAIR. Measurement of serum visfatin was done using ELISA.

Results
Serum visfatin and HOMAIR levels were significantly higher in acne patients compared to control subjects. Serum visfatin and HOMAIR provided significant discriminative power to differentiate acne patients from control subjetcs.
Effect of Intralesional Steroid Injection in Bilateral Benign Vocal Fold Lesions
Authors: Ghandour Hassan Hosny , Youssef Tanvr Ali , Refaat Ahmed Mohamnwd , El-sayed Hager Mohantmed 
Published: August 2023

Abstract

Background
Corticosteroids are one of the most potent inhibitors of inflammation and wound repair. Local injection of steroid gives the option of administration of a potent drug locally, thereby avoiding the systemic side effects of them. They have been used in the last decade in managing benign vocal fold lesions as intralesional steroid injection has the advantages of rapid subsidence of the inflammation and edema with rapid improvement of voice postoperatively

Ailil of the work
This study is designed to show clinical ancl encloscopic voice Iinprovelnent of microlaryngeal surgery alone versus microlaryngeal surgery of the prilnary lesion combined with steroid injection in the opposing lesion in patients with bilateral vocal fold benign lesions.

Patients and methods
40 patients with bilateral benign vocal fold lesions with Inoclerate to severe dysphonia are divided into two groups, one group underwent microlaryngo-surgery with excision of the primary lesion and injection of steroids into the contralateral lesions. The second group underwent microlaryngo-surgery with excision of the primary lesion only. Each subject was evaluated, preoperatively and postoperatively through a protocol including auditory perceptual assessment, laryngoscopic picture and self-rating by the patient using VHI.

Results
Comparing pre and post therapy results for each group, there was statistically significant improvcmcnt (reduction) in the size of thc contralatcral lesion and significant improvement in the quality of voice quality resulting in overall improvement in VHI.

Conclusion
Intralesional steroid injection in the contralateral lesion in bilateral benign vocal fold lesions is effective in improving voice quality postoperatively
Exploring Symptoms of Gastroesophageal Reflux in the Egyptian Patients with Non-Organic Voice Disorders
Authors: Alhanafy Hend Mohamed , Saad Baraka Mohamed Ali , Khodeir Mona Sameeh 
Published: August 2023

Abstract

Background
Gastroesophageal reflux disease (GERD) is an entity with heartburn, regurgitation, chest and stomach pain, and the feeling of gastric acid coming up.

Aim of the Work
This study aimed to explore symptoms of GERD in patients with nonorganic voice disorders using the Arabic version of Reflux Symptom Index (A-RSI).

Subjects and Methods
This study was applied on 50 Egyptian Arabic-speaking patients in the age range between 20 to 59 years old. Patients included were diagnosed with non-organic voice disorders according to the protocol of voice assessment used in the Phoniatrics outpatient clinic in Ain Shams University Hospitals. The participated patients were asked to fulfill the ARSI questions and their answers were related to their age, gender, duration of their voice symptoms, and the overall grade of their dysphonia as assessed by the GRBAS scale.

Results
Analysis of the answers of the participated patients to the A-RSI, revealed that only 40% of patients had a total score of the A-RSI above 13. This indicates that the participated patients with non-organic voice disorders have symptoms of GER. There was an insignificant correlation between the scores of the A-RSI and the age, gender, and duration of voice symptoms. The total score of A-RSI is indirectly related to the overall grade of dysphonia of the participated patients.

Conclusion
Patients with non-organic voice disorders have symptoms of GERD, however these symptoms are not related to the duration of their voice symptoms and related indirectly to the overall grade of their dysphonic voices. GER may be a contributing etiological factor in non-organic voice disorders but need to be confirmed by further assessment.
Efficacy of Anti-Reflux Medications on Improvement of Symptoms of Reflux Laryngitis
Authors: WF Ezzat , OM Mady , MT Bassiouny 
Published: August 2023

Abstract

Objectives/Hypothesis
reflux laryngitis is an inflammatory condition of the upper airway tract tissues due to the effect of gastric or duodenal content reflux, which provokes morphological changes in the upper aero digestive tract. Reflux laryngitis related symptoms affect up to 50% of patients in the Division of Laryngology. The purpose of this systematic review to shed light on the current therapeutic strategies used for the management of reflux laryngitis in order to determine the efficacy on improvement of symptoms.

Methods
the included studies published between 2003 and 2018. Regarding the type of included studies. All patients who suffer from reflux laryngitis in otorhinolaryngology clinics in included studies and treated by proton pump inhibitors or H2 blockers or prokinetics were added. Reviewed papers should include degree of improvement of any of the following symptoms: hoarseness, cough, Globus sensation, sore throat, dysphonic attacks, throat clearing non-productive cough, dysphagia, excessive throat mucus, etc. When using antireflux medications.

Results
The demographic characteristics and clinical data in all 15 studies are shown in the following tables: #Studies were arranged according to publication year. This table showed that; the included studies published between 2003 and 2018. The search identified 49 relevant papers, of which 15 studies met the inclusion criteria, accounting for 990 patients. The main therapeutic scheme consisted of once or twice daily PPIs for a duration ranged from 4 to 24 wk. The most used PPIs were omeprazole, esomeprazole, rabeprazole, lansoprazole and pantoprazole with a success rate ranging from 18% to 87%. Other composite treatments have been prescribed including PPIs, prokinetics, and H2 Receptor antagonists.

Conclusions
LPRD is more common in the age group of 31-40 years and proton pump inhibitors and prokinetics are highly effective in controlling laryngeal reflux symptom index and laryngeal reflux finding score.
Validation of a Modified Cow’s Milk-Related Symptom Score (CoMiSS) for Screening of Lactose Intolerance in Adults
Authors: Mohammed Heba Ibrahim , Baioumy Essam , Allam Mohamed Farouk , Al-Ashram Mohamed Nabil Badawy 
Published: August 2023

Abstract

Introduction
Lactose intolerance is the failure to digest foods and beverages containing the lactose present in milk. Lactose intolerance can be presented by many digestive symptoms.

Objective
To validate the modified CoMiSS score for the prediction of lactose intolerance, that was confirmed by a stool acidity test.

Patients and Methods
A crosssectional study, conducted on Ain Shams University Hospitals/ Gastrointestinal Clinics, enrolled100 adult participants during the period from December 2018 to December 2019, with the presence of one or more gastrointestinal symptoms, and subjected to a stool acidity test as a reference test and modified CoMiSS as index test.

Results
The mean age of participants was 35.30 ± 10.714 years old; 55% were females, and mean BMI was 23.08 ± 2.080 kg/m2, with no statistically significant difference between lactose intolerance and patients gender or body mass index BMI, 24% of participants had positive stool PH, lactose Intolerance diagnosed according to modified CoMISS Score among 19% of study participants, the mean of modified CoMISS Score in positive cases (12.37) were highly statistically significant than those negative lactose intolerance (2.33) as p &lt; 0.001, Area under ROC Curve was 0.998, with cut-off value &gt;8. Sensitivity 89.5% and specificity was 100%.

Conclusion
Modified CoMiSS is a simple, fast, and easy-to-use tool that can predict lactose intolerance, with a cut-off value of &gt; 8, the Area under the ROC Curve was 0.998, sensitivity 89.5%, and specificity was 100%.
Development of Practice Guidelines for Peripartum Depression in Primary Healthcare
Authors: Korany Wafaa Mohamed , Marzouk Diaa , El-Hamid Abd , Allam Mohamed Farouk 
Published: August 2023

Abstract

Background
Antenatal and postpartum major depressive episode (MDE) according to Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-V) is defined as either daily sustained sad mood or lack of enjoyment or desire for a minimum two weeks plus four associated manifestations (only three if the two major symptoms are present): 1) Unintentional notable slimming up or down; 2) Sleepiness or sleeplessness; 3)Tiredness sensation; 4) Guilty or futility sensation; 5) Declined concentration capacity; 6) Frequent suicidal thoughts or 7) Psychomotor excitation or delay, that start throughout pregnancy or during the first 4 weeks postpartum respectively.

Objective
To develop Egyptian practice guidelines for peripartum depression in Primary Healthcare (PHC).

Methods
The current study was conducted thorough Delphi technique by participation of Thirteen experts at psychiatry and family medicine specialties from different governmental universities, Ministry of Health and Population (MOHP), World Health Organization (WHO) and World Organization of Family Doctors (WONCA) via email thorough three consecutive phases of Delphi technique.

Results
The current study recommended health education programs, provision of awareness about physical exercise’s importance for prevention of antenatal and postnatal depression, adding telephone- based peer support for the preventive measures of the antenatal depression and family therapy for the postpartum depression prevention. Screening for all the pregnant women every trimester by patient health questionnaire II and screening for all the new mothers every well child clinic visit in the first year after delivery by Edinburg Postpartum Depression Scale (EPDS). Diagnosis by beck depression inventory II questionnaire and Postpartum Depression Screening Scale (PDSS) for antenatal and postnatal depression respectively with post diagnosis evaluation for: 1) Comorbid anxiety; 2) Bipolar disorder; 3) Thoughts of harming intrauterine fetus or newborns; 4) Suicidal thoughts and 5) Psychotic features. Cognitive Behavioral Therapy (CBT) for treatment of mild cases and CBT with half dose sertraline for moderate cases of antenatal depression. Cognitive Behavioral Therapy (CBT) for mild cases, CBT and the usual dose sertraline for moderate cases with no hormonal therapy for any patient. Referral for patients with: 1) severe depression; 2) comorbid anxiety; 3) bipolar disorder; 4) thoughts of harming intrauterine fetus or newborns; 5) suicidal thoughts; 6) psychotic features; 7) substance abuse.

Conclusion
development of Egyptian practice guidelines for peripartum depression in PHC. Wide dissemination of the practice guidelines to all the Egyptian PHC facilities via a suitable method and training programs for the family physicians on practicing these guidelines must be ensured.
Comparative Evaluation of Onlay vs Sublay Mesh in Treatment of Ventral Hernias
Authors: Abd El- Naser Amr Abd El- Raouf , El- Aziz Ahmed Abd El- Razek Abd , Mahfouz Remon Mamdouh , El-Rahiem Ahmed Ezzat Abd 
Published: August 2023

Abstract

Background
Hernias of the anterior abdominal wall, or ventral hernias have a various type that can be categorized into primary ventral hernias which include two subtypes lateral ventral hernia, and midline ventral hernias, and incisional hernias (acquired hernias) is another type according to the location, occur at the site of a pervious surgical scar.

Objective
To compare the outcome of the onlay versus sublay mesh repair for ventral hernias in terms of mean operative time, frequency of post-operative wound infection, seroma formation, hematoma formation, flap necrosis, mesh infection, hospital stay and time for drain removal.

Patients and Methods
This study will be conducted on 30 patients presenting to Ain shams University hospitals with uncomplicated ventral hernias starting from February 2021 till July 2021.

Results
Regarding the post operative complications, Seroma formation was more in the onlay group and this was statistically significant. Other post operative complications like wound infection, flap necrosis, Mesh infection, hematoma formation was more in the onlay group but were found to be statistically insignificant in the present study. Regarding the time taken for drain removal was more in the onlay group and this was statistically significant.

Conclusion
Sublay mesh repair is a good alternative to onlay mesh repair. This study advocates this method of ventral hernia repair, as it is applicable to all sites of ventral hernia. The mesh is mostly hidden and anchored behind the rectus sheath, the complication rate is low, and there is low recurrence rate. Finally, we suggest carrying out more trials on the sublay mesh repair technique to include bigger number of cases and longer period of follow-up.
Role of Laser Ablation of Fistula Tract in High Perianal Fistula
Authors: Nada Mohamed Ali , Abbas Ahmed Adel , Abdel-Makasoud Ibrahim Maged , Awad Ahmed Khairy 
Published: August 2023

Abstract

Background
Complex anal fistula has been a hot topic in clinic. Many surgical techniques have been described for the treatment of such anal fistula, including the use of seton, fibrin glue, collagen plugs, rectal advancement flaps, fistulotomy with sphincter repair, and rerouting the fistula tract. However, the results have been variable, and no one procedure is superior to the others absolutely. It is worth our concern that the goal of any treatment procedure is to obliterate the tract and to have low recurrence rates while maintaining full continence. A fistulotomy lays open the fistulous tract, thus leaving smaller unepithelized wounds, which hastens the wound healing. Until now, fistulotomy is still the most widely used. But, the high cure rate is limited by the fact that laying open a transsphincteric fistula tract and cutting both the internal and the external sphincter has the risk of fecal incontinence ranging up to 40%.

Aim of the Work
To assess and evaluate the efficacy and safety of LASER ablation of high perianal fistula.

Patients and Methods
This study is a randomized prospective study which will be conducted at Ain Shams University hospitals recruiting (20) patients and will be operated upon between January 2021 and July 2021 with minimal follow up to 3 months postoperatively.

Results
From these studies, it emerges that this procedure has some advantages. It doesn’t affect continence, administers controlled hyperthermic effect to the tissues, has a short learning-curve and reduces postoperative hospital stay as compared to endorectal advancement flap or LIFT. However, it has also some drawbacks. It is a blind procedure, as it’s not possible a direct visualization of the fistula tract or any secondary tracts and this may lead to recurrence. It requires expensive equipment, particularly if compared to other sphincter-saving techniques.

Conclusion
LASER ablation is a technique that has a promising results regarding complex perianal fistula preserving anal continence and short healing period and low recurrence rate as regarding classic and other techniques.
Evaluation of Early & Late Hypocalcemia Post Total Thyroidectomy in the Early Learning Curve Retrospective Study
Authors: Elanwar Ali Mohamed , Omran Hesham Mohamed Ali , Elhamied Mohamed Abd Elstaar Abd , Abdallah Amer Abdelghany 
Published: August 2023

Abstract

Background
Hypocalcemia post total thyroidectomy, is one of the most common complications observed in patients who undergo bilateral thyroid resection. Although hypocalcemia is self-limiting in most patients and does not require treatment, symptomatic hypocalcemia is of particular concern. We aimed to evaluate the incidence of hypocalcemia post total thyroidectomy with an evaluation of serum calcium levels as a cheap and available method so we can identify patients at risk of postoperative hypocalcemia who require supplementation treatment, and those not at risk who can be safely discharged without any supplementation treatment.

Aim of the Work
To analyze the data of post total thyroidectomy regarding calcium level temporary and permanent in the early learning curve and compare it with the standard incidence of developing hypocalcemia with total thyroidectomy in the literature.

Patients and Methods
Retrospective analysis of 120 patients undergoing total thyroidectomy. Preservation of parathyroid glands and their blood supply was attempted in all cases. The patients were assessed for manifestations of hypocalcaemia after thyroidectomy. The assessment was done through (1) monitoring the total and ionized calcium level 24 hours postoperatively, (2) Total and ionized calcium level was measured in the third week postoperative, (3) clinical examination and detection of symptoms and signs of hypocalcaemia, (4) In resistant cases assessment of total and ionized calcium and PTH at 3 and 6 months.

Results
The study included 103 females and 17 males, 37 was the mean age; 15 patients developed symptoms of hypocalcaemia all of them recovered from hypocalcaemia except 1 patient.

Conclusion
There is no difference between the incidence of temporary and permanent hypocalcemia in the early learning curve and the standard incidence of temporary and permanent hypocalcemia post total thyroidectomy