bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of micrognathia by prenatal ultrasound may improve timely diagnosis and management of infants with Robin sequence
Authors: Smith Emily C. , Craigo Sabrina D. , Scott Andrew R. 
Published: January 2023

AbstractObjectiveRobin sequence (RS) is a craniofacial anomaly characterized by small jaw (micrognathia) with associated tongue base airway obstruction. With advances in fetal imaging, micrognathia may be detected prenatally. This study aims to determine if prenatal recognition of micrognathia offers any advantage over being unaware of the condition until after delivery and to assess if prenatal consultation for micrognathia adds benefits beyond merely noting the presence of the condition.MethodRetrospective chart review examining cases from 01/01/2010 to 12/31/2020 at an urban tertiary medical center.ResultsForty seven infants with RS were included. 40.4% (n = 19) had micrognathia/retrognathia noted on prenatal ultrasound. 47.4% (n = 9) of those 19 pregnancies saw a maternal fetal medicine (MFM) program with craniofacial consultation. Compared to 28 infants not diagnosed with micrognathia until after birth, the 19 infants identified prenatally required fewer transfers from birth hospital (p = 0.02). Additionally, those referred to MFM with craniofacial consultation had shorter lengths of stay when airway intervention was required (p = 0.05).ConclusionPrenatal recognition of micrognathia may lead to early detection and management of RS. When RS is suspected, prenatal consultation with MFM and craniofacial team may further optimize care of the infant following delivery.
Diagnostic yield and psychological outcomes among women pursuing trio‐exome sequencing: Do women with recurrent anomalous fetal phenotypes experience more negative psychological outcomes?
Authors: Talati Asha N. , Gilmore Kelly L. , Hardisty Emily E. , Lyerly Anne D. , Rini Christine , Vora Neeta L. 
Published: January 2023

AbstractPurposeTo describe psychological outcomes among people with recurrent anomalous pregnancies pursuing trio‐exome sequencing (exome sequencing (ES)) compared to those with one affected.MethodsWe analyzed data from a prospective ES cohort, enrolling patients with major fetal anomaly and normal microarray. Participants completed validated scales before and after ES. We (1) compared responses of those with multiple anomalous pregnancies to those with one affected and (2) conducted linear regression to examine associations between multiple affected pregnancies and post‐ES constructs.ResultsOf 166 trios, 61 (37%) received results from ES. Forty (24%) had more than one affected pregnancy and 45% of those received a result explaining the fetal phenotype. All participants had clinically significant presequencing generalized psychological distress. For the 93 who completed the post‐ES surveys, those with multiple affected pregnancies had higher psychological adaptation scores but worse test related distress scores (9.3 (6.2) versus 7.1(5.6), p = 0.12) and (14.3 (1.5) versus 15.4 (1.4), p = 0.01). In linear regression models, there were no significant differences in post‐ES constructs after adjusting for clinically relevant covariates.ConclusionsAll individuals experienced significant generalized psychological distress in the pre‐ES period, extending our knowledge of how pregnancy history contributes to parental sequencing outcomes.
In situ polymerization of ethylene with functionalized multiwalled carbon nanotubes using a zirconocene aluminohydride system in solution
Authors: Miranda Cristal Cabrera , Camacho Odilia Pérez , Colunga Guillermo Martínez , Zamora Maricela García , Hernández María Teresa Rodríguez , Padilla Víctor Comparán , Collins Scott 
Published: January 2023

AbstractThis study reports nanocomposite synthesis based on high‐density polyethylene with carbon nanotubes through in situ polymerization by coordination, and the use of an aluminohydride zirconocene/MAO system as a catalyst. Nanocomposites of linear polyethylene exhibit higher molar masses than pure high‐density polyethylene synthesized under similar conditions; where multiwalled carbon nanotubes (MWCNTs) acted as nucleating agents, shifting the crystallization temperature to higher values than neat high‐density polyethylene. Well‐dispersed MWCNTs in the HDPE matrices of the obtained nanocomposites are observed by SEM, where most of the nanocomposites showed an improvement in their thermal stability and electric conductivity, besides it is possible to obtain nanocomposites containing up to 41 wt% of nanofiller in the polymeric matrix. The aluminohydride complex n‐BuCp2ZrH3AlH2, activated with MAO at Al/Zr ratios of 2000, produced homogeneous HDPE/MWCNT composites under in situ polymerization conditions, at 70°C and 2.9 bar of ethylene pressure, with minimal residual alumina in the HDPE matrix.
A simplified and masking‐free doping process for interdigitated back contact solar cells using an atmospheric pressure chemical vapor deposition borosilicate glass / phosphosilicate glass layer stack for laser doping followed by a high temperature step
Authors: Heilig Matthias , Wurmbrand Daniel , Hahn Giso , Terheiden Barbara 
Published: January 2023

AbstractIn this paper a simplified approach for the generation of laterally p‐ and n‐doped structures applicable for cost‐effective production of interdigitated back contact (IBC) solar cells is presented. We use a stack of doping glasses deposited by atmospheric pressure chemical vapor deposition (APCVD), consisting of borosilicate glass (BSG) and phosphosilicate glass (PSG) on Czochralski‐grown (Cz) silicon substrates. A laser process creates the p‐doped regions by local liquid phase diffusion of boron from the BSG layer into the underlying molten Cz‐Si substrate. Simultaneously, the BSG‐PSG stack is removed by laser ablation. In a subsequent high‐temperature step, phosphorus diffuses from the remaining PSG‐BSG layer into the crystalline silicon substrate under inert gas atmosphere, creating complementary to laser doped areas n+‐doped regions. By the use of APCVD, phosphorus and boron contents of the doping glasses can be adjusted freely to vary the resulting p‐ and n‐doped profiles. A higher boron content in the BSG layer enhances the diffusion of phosphorus through the BSG, especially at lower diffusion temperatures. The resulting doping profiles are characterized using electrochemical capacitance‐voltage measurements and the resulting sheet resistances using the four‐point probe method. The amount of minority dopant contamination in n‐ and p‐doped regions is investigated by secondary ion mass spectrometry. Furthermore, transfer length method (TLM)‐measurements indicate contactability of the generated doped regions.
Investigation of the role of personality traits and emotion regulation on personality functioning in patients with depression/anxiety disorder
Authors: Katar Kübra Sezer , Örsel Sibel , Gündoğmuş Ayse Gökçen 
Published: January 2023

AbstractThe relationship between the dimensional assessment of personality and difficulties in emotion regulation has yet to be made clear. The present study aimed to investigate the role of personality traits and emotion regulation on personality functioning. Difficulties in Emotion Regulation Scale (DERS), Beck Anxiety Inventory, Beck Depression Inventory, Personality Inventory for DSM‐5 (PID‐5) and Level of Personality Functioning Scale (LPFS) were rated for 220 patients with depression and/or anxiety disorder diagnosis and 100 healthy controls. Stepwise regression analyses (SRA) were used to find potential predictors of personality functioning, and generalized linear analyses (GLA) were used to find mediators between the traits and personality functioning. SRA results in the clinical group showed that higher depression, antagonism, difficulties in impulse control and difficulties in awareness predicted higher levels of dysfunction in personality. According to GLA results in the clinical group, the impulse subscale of DERS partially mediated the relationship between antagonism and level of impairment in personality functioning. Our results indicate that certain emotion regulation styles and personality traits play an important role in predicting personality functioning in the clinical sample of depression and anxiety patients. Future studies should focus on specific emotion dysregulation strategies and broaden the dimensional personality literature in different samples.
Resolving the enthalpy of protein stabilization by macromolecular crowding
Authors: Stewart Claire J. , Olgenblum Gil I. , Propst Ashlee , Harries Daniel , Pielak Gary J. 
Published: January 2023

AbstractProteins in the cellular milieu reside in environments crowded by macromolecules and other solutes. Although crowding can significantly impact the protein folded state stability, most experiments are conducted in dilute buffered solutions. To resolve the effect of crowding on protein stability, we use19F nuclear magnetic resonance spectroscopy to follow the reversible, two‐state unfolding thermodynamics of the N‐terminal Src homology 3 domain of theDrosophilasignal transduction protein drk in the presence of polyethylene glycols (PEGs) of various molecular weights and concentrations. Contrary to most current theories of crowding that emphasize steric protein–crowder interactions as the main driving force for entropically favored stabilization, our experiments show that PEG stabilization is accompanied by significant heat release, and entropy disfavors folding. Using our newly developed model, we find that stabilization by ethylene glycol and small PEGs is driven by favorable binding to the folded state. In contrast, for larger PEGs, chemical or soft PEG–protein interactions do not play a significant role. Instead, folding is favored by excluded volume PEG–protein interactions and an exothermic nonideal mixing contribution from release of confined PEG and water upon folding. Our results indicate that crowding acts through molecular interactions subtler than previously assumed and that interactions between solution components with both the folded and unfolded states must be carefully considered.
Epitope‐directed anti‐SARS‐CoV‐2 scFv engineered against the key spike protein region could block membrane fusion
Authors: Jaiswal Deepika , Kumar Ujjwal , Gaur Vineet , Salunke Dinakar M. 
Published: January 2023

AbstractThe newly emerged SARS‐CoV‐2 causing coronavirus disease (COVID‐19) resulted in >500 million infections. A great deal about the molecular processes of virus infection in the host is getting uncovered. Two sequential proteolytic cleavages of viral spike protein by host proteases are prerequisites for the entry of the virus into the host cell. The first cleavage occurs at S1/S2 site by the furin protease, and the second cleavage at a fusion activation site, the S2′ site, by the TMPRSS2 protease. S2′ cleavage site is present in the S2 domain of spike protein followed by a fusion peptide. Given the S2′ site to be conserved among all the SARS‐CoV‐2 variants, we chose an S2′ epitope encompassing the S2′ cleavage site and generated single‐chain antibodies (scFvs) through an exhaustive phage display library screening. Crystal structure of a scFv in complex with S2′ epitope was determined. Incidentally, S2′ epitope in the scFv bound structure adopts an alpha‐helical conformation equivalent to the conformation of the epitope in the spike protein. Furthermore, these scFvs can bind to the spike protein expressed either in vitro or on the mammalian cell surface. We illustrate a molecular model based on structural and biochemical insights into the antibody‐S2′ epitope interaction emphasizing scFvs mediated blocking of virus entry into the host cell by restricting the access of TMPRSS2 protease and consequently inhibiting the S2′ cleavage competitively.
Comprehensive multicomponent characterization and quality assessment of Shuang‐Huang‐Lian powder injection using ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight‐mass spectrometry and ultra‐high‐performance liquid chromatography‐quadrupole‐Orbitrap‐mass spectrometry
Authors: Yin Jiaxin , Li Chao , Zhang Jie , Ding Hui , Han Lifeng , Yang Wenzhi , Li Fangyi , Song Xinbo , Bie Songtao , Yu Heshui , Li Zheng 
Published: January 2023

RationaleShuang‐Huang‐Lian powder injection (SHLPI) is a well‐known modern traditional Chinese medicine formula preparation (TCMFP) widely used to treat acute upper respiratory infections. However, SHLPI is extracted from pure Chinese medicine and administered through an injection, and many adverse reactions have been reported clinically. Therefore, it is necessary to characterize in depth the chemical composition of SHLPI and quantitatively analyze its potential allergenic components.MethodsIn this study, the samples were analyzed using ion mobility ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight‐mass spectrometry (UHPLC‐QTOF‐MS) combined with a self‐built database. Furthermore, the parallel reaction monitoring (PRM) model of ultra‐high‐performance liquid chromatography‐quadrupole‐Orbitrap‐mass spectrometry (UHPLC‐Q‐Orbitrap‐MS) was used to successfully quantify 10 representative bioactive components.ResultsUsing this strategy 90 compounds were identified, the fragmentation pathways of five representative compounds in the five main components of SHLPI were summarized, and 10 components (neochlorogenic acid, chlorogenic acid, sweroside, forsythiaside A, luteoloside, isochlorogenic acid B, isochlorogenic acid C, baicalin, phillyrin, and baicalein) were determine as the quality markers of SHLPI based on UPLC‐Q‐Orbitrap‐MS.ConclusionsThis work comprehensively characterized the material basis of SHLPI, summarized the cracking laws of representative substances, and quantitatively analyzed 10 potential allergenic components. Therefore, this study could provide a basis for the quality control of SHLPI and the clinical rational use of drugs to reduce its adverse reactions.
Output feedback stabilization of linear time‐varying systems with infinite distributed input delays
Authors: Zhou Qianghui , Xu Xiang , Liu Lu , Feng Gang 
Published: January 2023

AbstractThis article investigates the output feedback stabilization problem of linear time‐varying (LTV) systems with infinite distributed input delays. A novel observer is designed to estimate the system states and then a low gain output feedback controller is developed based on the estimated states. It is shown that the resulting closed‐loop control system is globally exponentially stable under some mild assumptions. Moreover, it should be pointed out that to the best of our knowledge, the output feedback stabilization problem of LTV systems with infinite distributed input delays has not yet been studied in open literature. Finally, two numerical examples are provided to illustrate the effectiveness of the proposed controllers.
One‐Step Electrodeposition of Multi‐element Doped Hydroxyapatite Nanocoating Leading to Enhanced Cytocompatible and Antibacterial Properties of Titanium Implants
Authors: Jia Fenghuan , Bian Anqi , Wu Zongze , Li Meiyu , Yang Hao , Huang Xiao , Xie Lei , Qiao Haixia , Lin He , Huang Yong 
Published: January 2023

AbstractThe introduction of trace elements into hydroxyapatite (HA) coatings has been widely used for antimicrobial and biocompatible modification of metal implants. In this study, a multifunctional coating of HA co‐doped with Cu2+, Zn2+, Sr2+ and F− (CuZnSrFHA) was synthesized on titanium substrate by one‐step electrodeposition technology. The CuZnSrFHA consisted of nanoscale needle‐like crystals with low roughness and poor hydrophilicity. However, it can continuously release Cu2+, Zn2+ and Sr2+ within 14 days while maintaining good physiological stability. Based on the synergistic effect of Cu and Zn, the CuZnSrFHA coating showed some inhibitory effect on E. coli and S. aureus. Furthermore, the CuZnSrFHA was not significantly cytotoxic and promoted early adhesion and alkaline phosphatase activity of osteoblasts. In conclusion, the multi‐element co‐doped CuZnSrFHA coating was expected to be a novel surface modification material for the prevention of infectious bone defects.
Insights into 4,4′‐Arylmethylene‐Bis‐1H‐Pyrazol‐5‐Ols Scaffolds: Various Synthetic Routes and Their Applications
Authors: Kanagare Anant B. , Yadav M.Sc.Ashok R. , Katariya Ashishkumar P. , Bhagat Devidas S. , Dhas Ajit K. , Pansare Dattatraya N. , Nagwade Pratik A. , Kumar Brajesh , Sangshetti Jaiprakash N. , Deshmukh Satish U. 
Published: January 2023

AbstractPyrazole and its derivatives have grown in prominence over the past three decades due to their remarkable therapeutic effects and robust pharmacological potency. This review exclusively focused on synthesis of 4,4’‐arylmethylene‐bis‐1H‐pyrazol‐5‐ols scaffolds owing to their diversified applications along with C−C multiple bond formations in a one step. Last twenty years, more than ninety synthetic methodologies have been developed because of these motifs′ advanced applicability, which prompted researchers to study this molecule. We focused on this synthesis advancement till the last quarter of the year 2022 which summarizes all results of MCRs obtained in conventional and non‐conventional media. It will serve as a key role for synthetic organic chemists working in this field.
N‐coordinated Aluminum Complexes Catalyze the Hydrostannation of Alkynes
Authors: Wang Chengzhi , Wu Jin , Yan Ben , Ni Congjian , Ma Xiaoli , Yang Zhi 
Published: January 2023

AbstractThe effective catalytic activity of hydrostannation of internal and terminal alkynes has been developed by using aluminum complexes. A novel aluminum complex L1AlMe2 was synthesized and characterized. N‐coordinated aluminum complex LAlH2 was chosen to be the most desirable catalyst. Under relatively mild and solvent‐free conditions, excellent yields, regio‐ and stereoselectivities have been achieved. Possible mechanistic pathways for the formation of major products by hydrostannation of alkynes with HSnBu3 were proposed.
Lead‐Free Bismuth‐Based Halide Perovskites with Excellent Stability for Visible‐light‐Driven Photoelectrochemical Water Splitting
Authors: Nandigana Pardhasaradhi , Pari Sriram , Sujatha D. , Shidhin M. , Jeyabharathi C. , Panda Subhendu K. 
Published: January 2023

AbstractLead‐free halide perovskites have been developed as an alternative to lead‐based perovskite materials. Bi‐based halide perovskites Cs2AgBiCl6 and Cs3Bi2Cl9 are synthesized through the hydrothermal method and investigated their photoelectrochemical properties toward water splitting. The formation of the halide perovskites is confirmed by XRD, Raman spectroscopy, SEM, EDAX and XPS techniques. Optical properties are measured by UV‐Vis spectroscopy and Mott‐Schottky plots confirmed that both the materials are p‐type semiconductors with a bandgap of 2.72 eV and 3.05 eV for Cs2AgBiCl6 and Cs3Bi2Cl9 respectively. The photocurrent density of water oxidation on Cs2AgBiCl6 and Cs3Bi2Cl9 are 10 μA/cm2 and 6 μA/cm2 at 0.9 V (vs Ag/AgCl) respectively and both are highly stable over 300 sec under chopped condition and also the photoelectrocatalyst stable over 10 h during the chronoamperometry studies. The experimental data shows that the photoelectrochemical water splitting activity of Cs2AgBiCl6 is better than Cs3Bi2Cl9. This work suggests these materials will be a potential candidate for green hydrogen and oxygen production using solar energy.
Genetic dissection of monosaccharides contents in rice whole grain using genome‐wide association study
Authors: Panahabadi Rahele , Ahmadikhah Asadollah , Farrokhi Naser 
Published: January 2023

AbstractThe simplest form of carbohydrates are monosaccharides which are the building blocks for the synthesis of polymers or complex carbohydrates. Monosaccharide contents of 197 rice accessions were quantified by HPAEC‐PAD in rice (Oryza sativa L.) whole grain (RWG). A genome‐wide association study (GWAS) was carried out using 33,812 single nucleotide polymorphisms (SNPs) to identify corresponding genomic regions influencing neutral monosaccharides contents. In total, 49 GWAS signals contained in 17 genomic regions (quantitative trait loci [QTLs]) on seven chromosomes of rice were determined to be associated with monosaccharides contents of whole grain. The QTLs were found for fucose (1), mannose (1), xylose (2), arabinose (2), galactose (4), and rhamnose (7) contents, all of which are novel. Based on co‐location of annotated rice genes in the vicinity of GWAS signals, the constituents of the whole grain were associated with the following candidate genes: arabinose content with α‐N‐arabinofuranosidase, pectinesterase inhibitor, and glucosamine‐fructose‐6‐phosphate aminotransferase 1; xylose content with ZOS1‐10 (a C2H2 zinc finger transcription factor [TF]); mannose content with aldose 1‐epimerase‐like protein and a MYB family TF; galactose content with a GT8 family member (galacturonosyltransferase‐like 3), a GRAS family TF, and a GH16 family member (xyloglucan endotransglucosylase/hydrolase xyloglucan 23); fucose content with gibberellin 20 oxidase and a lysine‐rich arabinogalactan protein 19, and finally rhamnose content with myo‐inositol‐1‐phosphate synthase, UDP‐arabinopyranose mutase, and COBRA‐like protein precursor. The results of this study should improve our understanding of the genetic basis of the factors that might be involved in the biosynthesis, regulation, and turnover of monosaccharides in RWG, aiming to enhance the nutritional value of rice grain and impact the related industries.
Atypical hypoadrenocorticism presenting with hypoglycaemic seizures and bilateral cortical blindness in a dog
Authors: Harper Jenna , Burchell Richard 
Published: January 2023

AbstractA 4‐year‐old, neutered, female Jack Russell terrier cross was presented for an acute onset of obtundation, severe hypoglycaemia and generalised tonic‐clonic seizure activity. Baseline cortisol and subsequent adrenocorticotropic hormone stimulation testing confirmed hypoadrenocorticism, which was atypical as there were no electrolyte abnormalities present during hospitalisation or in the 6‐month follow‐up period. The dog responded to glucocorticoid monotherapy. To our knowledge, this is the only confirmed case of atypical hypoadrenocorticism presenting for hypoglycaemic seizures and bilateral cortical blindness in a dog. Hypoadrenocorticism (typical or otherwise) should be considered in dogs presenting for hypoglycaemic seizures.
A scoping review of the green parenthood effect on environmental and climate engagement
Authors: Shrum Trisha R. , Platt Natalie S. , Markowitz Ezra , Syropoulos Stylianos 
Published: January 2023

AbstractWe review the existing literature on the role of parenthood as a motivator of environmental engagement (the green parenthood effect), focusing particularly on climate change. We find that parenthood is severely understudied as a mechanism that may influence climate change‐relevant behavior. The literature on the role of parenthood in driving environmental engagement is mixed, due in part to the role of baseline individual and group characteristics that lead to different impacts of parenthood on environmental engagement as well as to the countervailing impact of intense time and budget constraints imposed by parenthood. Some studies suggest that parenthood increases pro‐environmental engagements, while others find no effects or negative effects. We theorize that potential mediators and moderators need to be taken into account to get a clearer picture of how parenthood influences pro‐environmental engagement. We highlight underlying proposed mechanisms that might be activated during the transition to parenthood (i.e., legacy motives, generativity, perceived responsibility), potential moderators of the green parenthood effect, and insights for public engagement.This article is categorized under:
Climate, Nature, and Ethics > Climate Change and Global Justice
Perceptions, Behavior, and Communication of Climate Change > Social Amplification/Attenuation of Climate Risks
Perceptions, Behavior, and Communication of Climate Change > Behavior Change and Responses
The Social Status of Climate Change Knowledge > Climate Science and Social Movements