bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous Nystagmus in Patients With Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo
Authors: Kim Chang‐Hee , Lee Dong‐Han , Lee Jiyeon , Shin Jung Eun , Park Joon Yong 
Published: January 2023

AbstractObjectiveThis study aimed to investigate the incidence of spontaneous nystagmus (SN) in posterior semicircular canal (PSCC) benign paroxysmal positional vertigo (BPPV) and its effect on treatment outcomes.Study DesignRetrospective case series.SettingTertiary referral center.MethodsThis study included 50 patients with idiopathic unilateral PSCC BPPV between July 2021 and May 2022. The presence of SN was investigated, and the results of the bithermal caloric test and video head impulse test (vHIT) were compared.ResultsSN was observed in 13 (26%) of the 50 patients presenting PSCC BPPV. The direction of SN was mainly unidirectional and horizontal in 12 of the 13 patients with a slow‐phase velocity ranging from 2 to 4°/s. One patient presented an upbeating torsional SN at the initial evaluation. The mean vHIT gain of the PSCC on the affected side was significantly lower in patients with SN than those without SN (p = .004, Mann‐WhitneyUtest). The proportion of patients who recovered within 2 sessions of the repositioning maneuver was significantly higher in those without SN than that in those with SN (p < .001, Fisher's exact test).ConclusionThis study demonstrated that the treatment outcomes of PSCC BPPV were significantly worse in patients with SN than those without SN. Examining the presence of SN in patients with PSCC BPPV may be helpful in counseling the patients on prognosis, and it is expected that more sessions of canalith repositioning maneuver may be required to treat PSCC BPPV in patients with SN than those without SN.
Self‐assembly of surfactin‐like polymer in solution by the dissipative particle dynamics method
Authors: Zhou Zhengwei , Wan Daihong , Zhou Junwei , Zhang Yixin , Wang Rong 
Published: January 2023

AbstractSurfactin is a kind of special and efficient cyclic lipopeptide biosurfactant, which is composed of a seven‐peptide ring and a fatty acid tail chain and is widely used in the fields of medicine, environmental remediation and heavy oil transportation. This special ring structure also makes surfactin have great application potential in biomedicine and surface catalysis. In this work, the self‐assembly behavior of surfactin‐like polymer in selective solvents was studied by dissipative particle dynamics. By changing the interaction parameters, the size of the hydrophilic ring, the length of the hydrophobic tail chain and the concentration, a series of structures such as vesicles, disk‐like micelles, worm‐like micelles, sphere‐like micelles and ring‐like micelles were obtained from the establishment of the phase diagram. We explored the dynamic formation paths of vesicles and ring‐like micelles and discovered morphological changes during their aggregation. The mechanism of sphere‐like micelle formation at lower concentration was also studied, explained by the packing of molecules of effective conical shape. The structural properties of the vesicles were also intensively studied. Based on the special ring structure of surfactin‐like polymers, we explored the difference in their self‐assembly behavior from those of linear block copolymers and giant surfactant‐like polymers. A detailed study on the self‐assembly of surfactin‐like polymer can deepen the understanding of ordered aggregates of cyclic surfactants in selective solvents and can drive important implications for their practical application. © 2023 Society of Industrial Chemistry.
When a plant invader meets its old enemy abroad: what can be learnt from accidental introductions of biological control agents
Authors: Müller‐Schärer Heinz , Sun Yan , Schaffner Urs 
Published: January 2023

AbstractAccidental introductions of biological weed control (BWC) agents (i) offer opportunities to assess host use of agents with a potentially broader fundamental host‐range than those approved for field release directly in target areas; (ii) urge national authorities to rapidly respond as they may threaten native species or crops, and by this (iii) help advancing post‐release studies, a neglected aspect of BWC. Through detailed insights gained from studying the recent accidental introduction of the ragweed leaf beetle Ophraella communa into Europe, we derive suggestions for overcoming barriers to adoption of BWC by re‐evaluating the predictive power of pre‐release studies and, thus, the presently strict criteria for deciding upon their release that might exclude safe and efficient agents. By using the allergenic weed Ambrosia artemisiifolia and the accidentally introduced BWC agent O. communa as study system, we also hope to raise the awareness of authorities to consider biological control more prominently as a key approach for pest management in the ‘One Health’ concept, which aims to sustainably balance and optimize the health of people, animals, plants and ecosystems. © 2023 Society of Chemical Industry.
Sustainable production of AlSi10Mg parts by laser powder bed fusion process
Authors: Mercurio Vincenza , Calignano Flaviana , Iuliano Luca 
Published: January 2023

AbstractLaser powder bed fusion (L-PBF) is an additive manufacturing technology that allows producing complex and lightweight parts without the use of specific tooling during the building process. However, despite continuous developments, some problems limit its use in series production. To introduce these systems in mass production, it is necessary to solve the problems and exceed the limits related to the requirements of industrialization: higher productivity, less material consumption, less over-production, and less waste, greater stability of the process, and higher quality of the final components. In this study, good practices to reduce resource consumption are presented. The production rate of the L-PBF technique was increased to produce AlSi10Mg alloy components. All the samples were manufactured with 90-µm-layer thickness increasing productivity by approximately 65%. A design of experiments (DOE) method was used to analyze the effect of process parameters on the densification percentage. The produced samples were observed with a non-destructive process, the X-ray computed tomography system, to detect the presence of defects and pores. It has been found that a combination of parameters can induce porosities with a morphology such that after stress relieving the density increases rather than decreases as has been widely discussed in the literature. The mechanical properties are comparable with the literature values for conventional technologies. Good values of as-built surface roughness were also achieved despite the layer thickness.
Hinokitiol for hypertensive emergencies: effects on peripheral resistance, cardiac load, baroreflex sensitivity, and electrolytes balance
Authors: Omar Hoda A. , El-Bassossy Hany M. , Hassan Noura A. 
Published: January 2023

AbstractHinokitiol, a natural monoterpenoid, has been shown previously to possess a potent vasodilating activity in vitro in both control and hypertensive aortae. Here, the antihypertensive and cardioprotective effects of an intravenous hinokitiol injection were fully investigated in angiotensin II-induced hypertensive emergency in rats. Hinokitiol intravenous injection was prepared in the form of self-nanoemulsifying drug delivery system. Rat’s arterial and ventricular hemodynamics were measured in real-time recordings in addition to surface electrocardiogram while slow injection of cumulative doses of hinokitiol or vehicle as well as time control. Hinokitiol at dose 10 mg/kg showed a considerable reduction in the raised systolic blood pressure (30 mmHg) within only 30 min. The decrease in blood pressure seems to be mediated through a reduction in peripheral resistance, as appears from the decreases in diastolic pressure, dicrotic notch pressure, and pulse pressure. In addition, hinokitiol injection reduced heart load due to the decrease in heart rate, increases in cycle duration (particularly the non-ejection duration) and diastolic duration, and decreases in end-diastolic pressure. An effect most likely mediated via prolongation of ventricular repolarization as appears from the increases in PR, QTc, and JT intervals. However, acute intravenous injection of hinokitiol neither affected the baroreflex sensitivity nor sodium/potassium balance. In conclusion, acute hinokitiol intravenous injection markedly reduced severe hypertension in rats. This effect seems to be mediated through decreasing peripheral resistance and decreasing cardiac load, suggesting that it is an effective treatment in hypertensive emergencies after clinical evaluation.
Medial joint space narrowing progresses after pullout repair of medial meniscus posterior root tear
Authors: Kawada Koki , Furumatsu Takayuki , Tamura Masanori , Xue Haowei , Higashihara Naohiro , Kintaka Keisuke , Yokoyama Yusuke , Ozaki Toshifumi 
Published: January 2023

Abstract
Purpose
The extent to which arthropathic changes progress after medial meniscus posterior root tear (MMPRT) repair remains controversial. This retrospective study assessed medial joint space (MJS) narrowing progression after pullout repair for MMPRT and identified the correlating factors.

Methods
We included 56 patients who underwent pullout repair for MMPRT. The MJS of the bilateral knees was assessed with radiography using the fixed-flexion view. A second-look arthroscopy was performed one year post-operatively for all patients. The baseline characteristics, clinical scores, Kellgren–Lawrence (KL) grade, and medial meniscus extrusion (MME) were identified. Statistical comparisons and correlation analyses were conducted.

Results
The MJS narrowing width was significantly larger in MMPRT knees than in contralateral knees (0.51 ± 0.85 mm vs. 0.09 ± 0.49 mm, p < 0.001). KL grade progression was observed in 23.2% (13/56) of patients. There was a significant difference between pre- and post-operative MME values, indicating MME progression (p < 0.001). Each clinical score showed significant improvement one year post-operatively (p < 0.001). Positive correlations were found between MJS narrowing and pre-operative MJS (coefficient = 0.510, p < 0.001), rate of change in MJS (coefficient = 0.929, p < 0.001), and increase in MME (ΔMME) (coefficient = 0.506, p < 0.001).

Conclusion
Knees that underwent pullout repair for MMPRT showed progression of MJS narrowing by 0.51 mm at one year post-operatively, although clinical scores markedly improved. Correlating factors for MJS narrowing were pre-operative MJS, rate of change in MJS, and ΔMME. Preventing MME progression is essential for preventing arthropathic changes.
The morphological classification and clinical significance of atlas vertebral artery sulcus based on computed tomography three-dimensional reconstruction
Authors: Hu Dingxiang , Li Changhui , Chen Liang , Ma Chenxi , Huang He , Zheng Ruiqing 
Published: January 2023

Abstract
Objective
The purpose of this study was to research the morphological classification and clinical significance of vertebral artery sulcus on atlas based on CT three-dimensional reconstruction.

Methods
Three-dimensional reconstruction images of 300 adult atlases were collected. A total of 600 atlas vertebral artery sulci were selected in this study. The parameters required for placement of C1 pedicle screw, including depth of grinding drilling (ao), width (cd), length ab), height (H), lateral wall thickness (L1), inner wall thickness (L2), medial angle (∠α), and the cephalad angle to the transverse plane of atlas pedicle (∠β), were measured.

Results
CT three-dimensional reconstruction images showed that there were five types of atlas vertebral artery sulci: no process type (n = 494 cases, 82.33%), upper process type (n = 29, 4.83%), lower process type (n = 25, 4.17%), double process type (n = 19, 3.17%), and posterior ring type (33, 5.50%). One-way ANOVA tests showed that the five groups differed significantly in the parameter of ao, L2, H, ∠α and ∠β. One-way ANOVA with the LSD post hoc tests showed that the parameter ao of the group of no process type was less than that of the group of upper or lower process type (P < 0.05), and ao of the group of lower process or posterior ring type was less than that of the group of the upper type (P < 0.05). The parameter of ao of the male group was larger than that of the female group.

Conclusion
No process type of the atlas vertebral artery sulcus was the most common, and the medial angle and cephalad angle of the atlas pedicle in this type were the smallest. When pedicle screws are inserted, the above two angles should not be too large. Male's ao was larger than that of female's. All these findings should be considered to avoid the deviation of the nail track.
Functional connectivity changes between amygdala and prefrontal cortex after ECT are associated with improvement in distinct depressive symptoms
Authors: Domke Ann-Kathrin , Hempel Moritz , Hartling Corinna , Stippl Anna , Carstens Luisa , Gruzman Rebecca , Herrera Melendez Ana Lucia , Bajbouj Malek , Gärtner Matti , Grimm Simone 
Published: January 2023

AbstractElectroconvulsive therapy (ECT) is one of the most effective treatments for treatment-resistant depression. However, the underlying mechanisms of action are not yet fully understood. The investigation of depression-specific networks using resting-state fMRI and the relation to differential symptom improvement might be an innovative approach providing new insights into the underlying processes. In this naturalistic study, we investigated the relationship between changes in resting-state functional connectivity (rsFC) and symptom improvement after ECT in 21 patients with treatment-resistant depression. We investigated rsFC before and after ECT and focused our analyses on FC changes directly related to symptom reduction and on FC at baseline to identify neural targets that might predict individual clinical responses to ECT. Additional analyses were performed to identify the direct relationship between rsFC change and symptom dimensions such as sadness, negative thoughts, detachment, and neurovegetative symptoms. An increase in rsFC between the left amygdala and left dorsolateral prefrontal cortex (DLPFC) after ECT was related to overall symptom reduction (Bonferroni-corrected p = 0.033) as well as to a reduction in specific symptoms such as sadness (r = 0.524, uncorrected p = 0.014), negative thoughts (r = 0.700, Bonferroni-corrected p = 0.002) and detachment (r = 0.663, p = 0.004), but not in neurovegetative symptoms. Furthermore, high baseline rsFC between the left amygdala and the right frontal pole (FP) predicted treatment outcome (uncorrected p = 0.039). We conclude that changes in FC in regions of the limbic-prefrontal network are associated with symptom improvement, particularly in affective and cognitive dimensions. Frontal-limbic connectivity has the potential to predict symptom improvement after ECT. Further research combining functional imaging biomarkers and a symptom-based approach might be promising.
Characterization of a polyclonal antibody that is highly selective for the d-isoAsp-25 variant of mammalian histone H2B
Authors: Aswad Dana W. , O’Leary Kevin S. , Williams Katherine 
Published: January 2023

AbstractApproximately 12% of histone H2B molecules in mammalian brain contain a modification wherein Asp25 is present as the d-enantiomer, and is mostly linked to Gly26 via the side-chain carboxyl. Here we (1) demonstrate the high specificity of a polyclonal antibody to this modification, and (2) use this Ab to demonstrate that this modification is enriched in brain relative to liver, thymus, and HeLa cells.
On the road with RTLola
Authors: Biewer Sebastian , Finkbeiner Bernd , Hermanns Holger , Köhl Maximilian A. , Schnitzer Yannik , Schwenger Maximilian 
Published: January 2023

AbstractThis paper is about shipping runtime verification to the masses. It presents the crucial technology enabling everyday car owners to monitor the behaviour of their cars in-the-wild. Concretely, we present an Android app that deploys rtlola runtime monitors for the purpose of diagnosing automotive exhaust emissions. For this, it harvests the availability of cheap Bluetooth adapters to the On-Board-Diagnostics (obd) ports, which are ubiquitous in cars nowadays. The app is a central piece in a set of tools and services we have developed for black-box analysis of automotive vehicles. We detail its use in the context of real driving emission (rde) tests and report on sample runs that helped identify violations of the regulatory framework currently valid in the European Union.
The developments in amniotic membrane transplantation in glaucoma and vitreoretinal procedures
Authors: Sharma Rohit , Nappi Vivian , Empeslidis Theodoros 
Published: January 2023

AbstractThe main reasons why Amniotic Membrane (AM) is transplanted in Ophthalmology are: to provide a substrate for cellular growth and to provide tectonic support or as a biological bandage and barrier that protects the wound to facilitate an environment for wound healing. The application of AM is well-documented in corneal disorders of various aetiologies [1], however, research within the field has highlighted how it can be used in conjunctival disorders and most recently, in glaucoma and vitreoretinal procedures. This review explores the preservation modalities of AM and summarises the current literature regarding AM transplantation in Glaucoma and Vitreoretinal conditions. AM transplantation in conjunction with trabeculectomy was reported to be used in two different surgical techniques. They differ in relation to the position of the implant: below the scleral flap or over the entire exposed sclera. The results of these studies suggest that AM transplant is a safe procedure that helps in the improvement of the intraocular pressure when associated with trabeculectomies. Moreover, it enhances trabeculectomies success rates when used along with mitomycin C [2]. The use of AM is also described for managing leaking blebs. It is mentioned to be a suitable alternative to conjunctival advancement. Regarding AM transplantation in glaucoma shunt or valve surgeries, the current literature is relatively limited. However, AM has been described as a good tectonic support for shunt procedures [3]. Successful results are described in the literature for surgical treatments using AM plug for vitreoretinal procedures. In particular macular hole closure and rhegmatogenous retinal detachment. In conclusion, AM transplant is a very promising and versatile adjutant therapy. However, further studies are also required for a better understanding and refinement of surgical techniques.
A viscoelastic–viscoplastic model for adhesives subjected to reversed cyclic load
Authors: Chen Yi , Smith Lloyd V. 
Published: January 2023

AbstractThis study aims to describe a toughened adhesive’s ratcheting–recovery behavior under reversed cyclic load using a viscoelastic–viscoplastic model. As most adhesives are based on synthetic polymers, their tensile and compression response can be different. A series of load–Sunload tests were conducted on bulk adhesives and bonded joints involving tension/compression–shear loads to characterize the initial yield surface. The effect of hydrostatic stress was studied by considering the instantaneous response and yield strength under tensile and compression loads. Given the observed modulus degradation and extensive permanent strain during reversed cyclic tests, time-dependent damage factors were considered for both viscoelastic and viscoplastic responses. The model was implemented in a finite element (FE) code and used to model the shear response to reversed cyclic load with varying frequency. Good agreement between the model and experiment was obtained. The consideration of both hydrostatic stress and damage was required to describe the observed adhesive reversed cyclic response.
Reference values of four measures of craniocervical stability using upright dynamic magnetic resonance imaging
Authors: Nicholson Leslie L. , Rao Prashanth J. , Lee Matthew , Wong Tsz Ming , Cheng Regen Hoi Yan , Chan Cliffton 
Published: January 2023

Abstract
Purpose
To establish reference ranges for four most commonly used diagnostic measures of craniocervical instability (CCI) in three cervical sagittal positions. This necessitated development of a reliable measurement protocol using upright, dynamic MRI (udMRI), to determine differences in the extent of motion between positions, and whether age and sex correlate with these measures.

Materials and Methods
Deidentified udMRIs of 50 adults, referred for reasons other than CCI, were captured at three positions (maximal flexion, maximal extension and neutral). Images were analyzed, providing measures of basion-axial interval, basion-axial angle, basion-dens interval (BDI) and the Grabb–Oakes line (GOL) for all three positions (12 measures per participant). All measures were independently recorded by a radiologist and neurosurgeon to determine their reliability. Descriptive statistics, correlations, paired and independent t-tests were used. Mean (± 2 SD) identified the reference range for all four measures at each craniocervical position.

Results
The revised measurement protocol produced inter-rater reliability indices of 0.69–0.97 (moderate–excellent). Fifty adults’ (50% male; mean age 41.2 years (± 9.7)) reference ranges for all twelve measures were reported. Except for the BDI and GOL when moving between neutral and full flexion, significant extents of movement were identified between the three craniocervical positions for all four measures (p ≤ 0.005). Only a minor effect of age was found.

Conclusions
This is the first study to provide a rigorous standardized protocol for four diagnostic measures of CCI. Reference ranges are established at mid and ends of sagittal cervical range corresponding to where exacerbations of signs and symptoms are commonly reported.
Nicely structured positive bases with maximal cosine measure
Authors: Hare Warren , Jarry-Bolduc Gabriel , Planiden Chayne 
Published: January 2023

AbstractThe properties of positive bases make them a useful tool in derivative-free optimization and an interesting concept in mathematics. The notion of thecosine measurehelps to quantify the quality of a positive basis. It provides information on how well the vectors in the positive basis uniformly cover the space considered. The number of vectors in a positive basis is known to be between$$n+1$$n+1and 2ninclusively. When the number of vectors is strictly between$$n+1$$n+1and 2n, we say that it is an intermediate positive basis. In this paper, the structure of intermediate positive bases with maximal cosine measure is investigated. The structure of an intermediate positive basis with maximal cosine measure over a certain subset of positive bases is provided. This type of positive bases has a simple structure that makes them easy to generate with a computer software.