bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geochronology, petrogenesis, and mineralization potential of the syenogranites in the Yama fluorite deposit, Tataleng granitic batholith, Qilian Orogen, NW China
Authors: Jiao He , Lu Hai-Feng , Huang Guo-Biao , Cui Qiang-Qiang , Ding Qing-Feng , Zhou Xuan , Wu Rui-Zhe 
Published: July 2023

The Yama fluorite deposit in the Qilian Orogen in NW China is characterized by predominant granitic magmatism and fluorite mineralization. The wall rocks hosting the fluorite–quartz veins in the Yama area consist of the Yama porphyritic syenogranite and the Wulandawu syenogranite. In this study, the major and trace element compositions, zircon U–Pb ages, and zircon Hf isotopes and trace element compositions were investigated. Two samples for the Yama porphyritic syenogranite yielded weighted mean 206Pb/238U zircon ages of 440.7 ± 4.8 and 447.9 ± 6.0 Ma, and one sample for the Wulandawu syenogranite yielded a weighted mean 206Pb/238U zircon age of 441.2 ± 5.0 Ma, all of which indicate a Late Ordovician to Early Silurian crystallization age. Geochemically, both syenogranites are peraluminous, with high alkali contents, low Zr + Nb + Ce + Y contents, relatively low (K2O + Na2O)/CaO ratios, and high Rb/Sr and Rb/Ba ratios, suggesting that they are fractionated S-type granites. They have zircon εHf( t) values of −14.9 to −4.4 and −12.2 to −4.5, respectively, suggesting that they were derived from the partial melting of pelitic-rich sources within the relatively shallow Paleoproterozoic reworked crust. The detailed geochronological and geochemical data suggest that the studied syenogranites were emplaced in a post-collisional setting related to the closure of the South Qilian Ocean. Finally, they have relatively low quantitative oxygen fugacity values, indicating relatively reduced redox states, but their very low zircon Ce4+/Ce3+ ratios, low whole-rock K/Rb ratios, relatively high Nb/Ta ratios, and low Zr/Hf ratios suggest that they are not likely to form important W–Sn deposits and related fluorite deposits.
Challenges of Using IFNγ in Clinical Settings
Authors: Singh Snahlata , Chakrabarti Rumela 
Published: July 2023

Abstract
Cytokines in the tumor microenvironment can affect tumor growth, progression, and response to therapy, making them compelling therapeutic agents and targets. IFNγ is a pleiotropic cytokine predominantly secreted by immune cells that binds to its receptors IFNGR1 and IFNGR2 on target cells. Multiple clinical trials have investigated the efficacy of IFNγ in combination with other therapies for treating patients with cancer and have shown varying results. Here, we summarize the known effects of IFNγ signaling on tumor cells and explore the possibility of its use in clinical settings.
Understanding and Overcoming Immunosuppression Shaped by Cancer Stem Cells
Authors: Li Linheng , Jensen Roy A. 
Published: July 2023

Abstract
Use of immunotherapy in recent years has revolutionized cancer treatment for certain types of cancers. However, the broad utility of immunotherapy is limited because there are still many types of cancer that do not respond effectively. Failure of a cancer to respond is due, at least in part, to its phenotypic plasticity, a feature that is established by cancer stem cells (CSC) and their associated microenvironments. This article discusses the current understanding of CSC-mediated immune evasion and provides a prospective view on how researchers can better understand and overcome the intrinsic immune privilege of CSCs and the extrinsic immune-suppressive microenvironment shaped by them.
Structural Vulnerabilities in DLBCL for Enhanced Treatment Strategies
Authors: Cristaldi Vanessa , Lund Amanda W. 
Published: July 2023

Abstract
Diffuse large B-cell lymphoma (DLBCL) is a typically immune-suppressed lymphoma subtype with poor response to immune checkpoint blockade and chimeric antigen receptor T-cell therapy. Recent data demonstrated an association between an activated, myofibroblast-like tumor stroma with improved outcome. On the basis of these findings, Apollonio and colleagues explored the phenotypic, transcriptional, and functional state of fibroblastic reticular cells (FRC) in human and murine DLBCL. This study reveals that DLBCL cells trigger the activation and remodeling of FRCs, leading to a chronic inflammatory state that supports malignant B-cell survival. Transcriptional reprogramming of the FRCs may inhibit CD8+ T-cell migration and function through changes in homing chemokines, adhesion molecules, and antigen presentation machinery, which together limit the anti-DLBCL immune response. High-dimensional imaging mass cytometry revealed heterogeneous CD8+ T-cell and FRC neighborhoods that associated with different clinical outcomes and ex vivo modeling of the microenvironment indicated an opportunity to target the FRC network for improved T-cell motility, infiltration, and effector function. This research broadens our understanding of the complex interactions between the lymph node microarchitecture and antitumor immune surveillance, defines structural vulnerabilities in DLBCL, and thereby offers opportunities for combined therapeutic approaches.
Cancer Incidence by Race and Immigration Status in Canada: Value of Enhanced Sociodemographic Data for Disease Surveillance
Authors: Withrow Diana R. , Gomez Scarlett Lin 
Published: July 2023

Abstract
Metrics of cancer burden stratified by race can inform tailored prevention strategies. Examining how these metrics, such as incidence, vary by immigration status can provide insight into the drivers of differential cancer risk by race. The conduct of such analyses in Canada has historically been hindered by a lack of sociodemographic data in routine health data sources, including cancer registries. In their recent study, Malagón and colleagues overcome this challenge by using National Cancer Registry data linked to self-reported race and place of birth from the Canadian census. The study provides estimates of cancer incidence for 19 cancer sites across more than 10 racial groups. Compared with the total population, they found that cancer risk tended to be lower among persons belonging to non-White, non-Indigenous racial groups. Exceptions were stomach, liver, and thyroid cancers where incidence rates were higher in minority groups than in the White population. For some cancers and racial groups, incidence was lower irrespective of immigration status, suggesting the healthy immigrant effect may be sustained across generations or that other factors are also at play. The results highlight potential areas for deeper inquiry and underscore the value of sociodemographic data for disease surveillance.
See related article by Malagón et al., p. 906
PreCancer Atlas: Present and Future
Authors: Srivastava Sudhir , Wagner Paul D. , Hughes Shannon K. , Ghosh Sharmistha 
Published: July 2023

Abstract
Precancer atlases have the potential to revolutionize how we think about the topographic and morphologic structures of precancerous lesions in relation to cellular, molecular, genetic, and pathophysiologic states. This mini review uses the Human Tumor Atlas Network (HTAN), established by the National Cancer Institute (NCI), to illustrate the construction of cellular and molecular three-dimensional atlases of human cancers as they evolve from precancerous lesions to advanced disease. We describe the collaborative nature of the network and the research to determine how and when premalignant lesions progress to invasive cancer, regress or obtain a state of equilibrium. We have attempted to highlight progress made by HTAN in building precancer atlases and discuss possible future directions. It is hoped that the lessons from our experience with HTAN will help other investigators engaged in the construction of precancer atlases to crystallize their thoughts on logistics, rationale, and implementation.
Implications of Social Disadvantage Score in Cardiovascular Outcomes and Risk Assessment: Findings From the Multi-Ethnic Study of Atherosclerosis
Authors: Hammoud Aziz , Chen Haiying , Ivanov Alexander , Yeboah Joseph , Nasir Khurram , Cainzos-Achirica Miguel , Bertoni Alain , Khan Safi U. , Blaha Michael , Herrington David , Shapiro Michael D. 
Published: July 2023

BACKGROUND:
Social determinants of health contribute to disparate cardiovascular outcomes, yet they have not been operationalized into the current paradigm of cardiovascular risk assessment.

METHODS:
Data from the Multi-Ethnic Study of Atherosclerosis, which includes participants from 6 US field centers, were used to create an index of baseline Social Disadvantage Score (SDS) to explore its association with incident atherosclerotic cardiovascular disease (ASCVD) and all-cause mortality and impact on ASCVD risk prediction. SDS, which ranges from 0 to 4, was calculated by tallying the following social factors: (1) household income less than the federal poverty level; (2) educational attainment less than a high school diploma; (3) single-living status; and (4) experience of lifetime discrimination. Cox models were used to examine the association between SDS and each outcome with adjustment for traditional cardiovascular risk factors. Changes in the discrimination and reclassification of ASCVD risk by incorporating SDS into the pooled cohort equations were examined.

RESULTS:

A total of 6434 participants (mean age, 61.9±10.2 years; female 52.8%; non-white 60.9%) had available SDS 1733 (26.9%) with SDS 0; 2614 (40.6%) with SDS 1; 1515 (23.5%) with SDS 2; and 572 (8.9%) with SDS ≥3. In total, 775 incident ASCVD events and 1573 deaths were observed over a median follow-up of 17.0 years. Increasing SDS was significantly associated with incident ASCVD and all-cause mortality after adjusting for traditional risk factors (ASCVD: per unit increase in SDS hazard ratio, 1.15 [95% CI, 1.07–1.24]; mortality: per unit increase in SDS hazard ratio, 1.13 [95% CI, 1.08–1.19]). Adding SDS to pooled cohort equations components in a Cox model for 10-year ASCVD risk prediction did not significantly improve discrimination (
P
=0.208) or reclassification (
P
=0.112).

CONCLUSIONS:
Although SDS is independently associated with incident ASCVD and all-cause mortality, it does not improve 10-year ASCVD risk prediction beyond pooled cohort equations.
Epileptogenic networks in extra temporal lobe epilepsy
Authors: Hall Gerard R. , Hutchings Frances , Horsley Jonathan , Simpson Callum M. , Wang Yujiang , de Tisi Jane , Miserocchi Anna , McEvoy Andrew W. , Vos Sjoerd B. , Winston Gavin P. , Duncan John S. , Taylor Peter N. 
Published: July 2023

Abstract
Extra temporal lobe epilepsy (eTLE) may involve heterogenous widespread cerebral networks. We investigated the structural network of an eTLE cohort, at the postulated epileptogenic zone later surgically removed, as a network node: the resection zone (RZ). We hypothesized patients with an abnormal connection to/from the RZ to have proportionally increased abnormalities based on topological proximity to the RZ, in addition to poorer post-operative seizure outcome. Structural and diffusion MRI were collected for 22 eTLE patients pre- and post-surgery, and for 29 healthy controls. The structural connectivity of the RZ prior to surgery, measured via generalized fractional anisotropy (gFA), was compared with healthy controls. Abnormal connections were identified as those with substantially reduced gFA (z &lt; −1.96). For patients with one or more abnormal connections to/from the RZ, connections with closer topological distance to the RZ had higher proportion of abnormalities. The minority of the seizure-free patients (3/11) had one or more abnormal connections, while most non-seizure-free patients (8/11) had abnormal connections to the RZ. Our data suggest that eTLE patients with one or more abnormal structural connections to/from the RZ had more proportional abnormal connections based on topological distance to the RZ and associated with reduced chance of seizure freedom post-surgery.
FRMT: A Benchmark for Few-Shot Region-Aware Machine Translation
Authors: Riley Parker , Dozat Timothy , Botha Jan A. , Garcia Xavier , Garrette Dan , Riesa Jason , Firat Orhan , Constant Noah 
Published: July 2023

Abstract
We present FRMT, a new dataset and evaluation benchmark for Few-shot Region-aware Machine Translation, a type of style-targeted translation. The dataset consists of professional translations from English into two regional variants each of Portuguese and Mandarin Chinese. Source documents are selected to enable detailed analysis of phenomena of interest, including lexically distinct terms and distractor terms. We explore automatic evaluation metrics for FRMT and validate their correlation with expert human evaluation across both region-matched and mismatched rating scenarios. Finally, we present a number of baseline models for this task, and offer guidelines for how researchers can train, evaluate, and compare their own models. Our dataset and evaluation code are publicly available: https://bit.ly/frmt-task.
OpenFact: Factuality Enhanced Open Knowledge Extraction
Authors: Song Linfeng , Wang Ante , Pan Xiaoman , Zhang Hongming , Yu Dian , Jin Lifeng , Mi Haitao , Su Jinsong , Zhang Yue , Yu Dong 
Published: July 2023

Abstract
We focus on the factuality property during the extraction of an OpenIE corpus named OpenFact, which contains more than 12 million high-quality knowledge triplets. We break down the factuality property into two important aspects—expressiveness and groundedness—and we propose a comprehensive framework to handle both aspects. To enhance expressiveness, we formulate each knowledge piece in OpenFact based on a semantic frame. We also design templates, extra constraints, and adopt human efforts so that most OpenFact triplets contain enough details. For groundedness, we require the main arguments of each triplet to contain linked Wikidata1 entities. A human evaluation suggests that the OpenFact triplets are much more accurate and contain denser information compared to OPIEC-Linked (Gashteovski et al., 2019), one recent high-quality OpenIE corpus grounded to Wikidata. Further experiments on knowledge base completion and knowledge base question answering show the effectiveness of OpenFact over OPIEC-Linked as supplementary knowledge to Wikidata as the major KG.
On Graph-based Reentrancy-free Semantic Parsing
Authors: Petit Alban , Corro Caio 
Published: July 2023

AbstractWe propose a novel graph-based approach for semantic parsing that resolves two problems observed in the literature: (1) seq2seq models fail on compositional generalization tasks; (2) previous work using phrase structure parsers cannot cover all the semantic parses observed in treebanks. We prove that both MAP inference and latent tag anchoring (required for weakly-supervised learning) are NP-hard problems. We propose two optimization algorithms based on constraint smoothing and conditional gradient to approximately solve these inference problems. Experimentally, our approach delivers state-of-the-art results on GeoQuery, Scan, and Clevr, both for i.i.d. splits and for splits that test for compositional generalization.
The feline skin microbiome: interrelationship between health and disease
Authors: Older Caitlin E , Hoffmann Aline Rodrigues , Diesel Alison B 
Published: July 2023

Practical relevance: As with other species, the skin microbiome of cats has been assessed over the past few years utilizing modern technologies. This has resulted in the identification of many more bacterial and fungal organisms compared with what had been recorded historically on the skin in various states of health and disease using culture-based studies. This information is expanding the knowledge of how microbial communities are impacted by various changes in the skin health of cats. More specifically, how these microbial communities change in the face of health and disease, and how various therapeutic interventions affect the cutaneous microbiome, lends a greater understanding of disease pathogenesis and provides a growing area of research for correcting dysbiosis and improving feline skin health. Evidence base: Most studies on the feline skin microbiome thus far have been descriptive in nature. These provide a framework for the next level of investigations on how various states of health and disease impact the products produced by the cutaneous microbiome (ie, the cutaneous metabolome), as well as how targeted interventions may promote the restoration of balance. Aims: This review aims to summarize what is currently known about the feline cutaneous microbiome and its clinical implications. The role of the skin microbiome in health and disease, the current state of research in this area and the potential for future studies to produce targeted interventions for cats are a particular focus.
Management and outcome of COVID-19 in CTLA-4 insufficiency
Authors: Ochoa Sebastian , Abers Michael S. , Rosen Lindsey B. , Rump Amy , Howe Katherine , Lieberman Jay A. , Wright Benjamin L. , Suez Daniel , Krausz Máté , Grimbacher Bodo , Lionakis Michail S. , Uzel Gulbu 
Published: July 2023

Abstract
Despite the high incidence of COVID-19 worldwide, clinical experience with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in inborn errors of immunity remains limited. Recent studies have shown that patients with defects in type 1 interferon (IFN)-related pathways or those with autoantibodies against type 1 IFNs develop severe COVID-19. We reported the clinical course of 22 patients with CTLA-4 insufficiency and COVID-19 and retrospectively examined autoantibodies against type 1 IFNs at baseline. Data were obtained from the patient interviews and chart reviews. Screening for anti-IFN autoantibodies was performed using a multiplex particle-based assay. Student t test, Mann Whitney, analysis of variance, or χ2 tests were used where appropriate. Twenty-two patients aged from 8 months to 54 years, with genetically confirmed CLTA-4 insufficiency, developed COVID-19 from 2020 to 2022. The most common symptoms were fever, cough, and nasal congestion, and the median duration of illness was 7.5 days. Twenty patients (91%) developed mild COVID-19 and were treated as outpatients. Two patients were hospitalized because of COVID-19 pneumonia but did not require mechanical ventilation. Ten (45%) patients were vaccinated at the time of their first COVID-19 infection. Eleven patients received outpatient treatment with monoclonal antibodies against the SARS-CoV-2 spike protein. During the study period, 17 patients were vaccinated against SARS-CoV-2, with no severe vaccine-related adverse effects. Although median anti-S titers following vaccination or infection were lower in patients receiving immunoglobulin replacement therapy (IGRT) (349 IU/dL) than in those not receiving IGRT (2594 IU/dL; P = .15); 3 of 9 patients on IGRT developed titers &gt;2000 IU/dL. All patients tested negative for autoantibodies against IFN-α, IFN-β, and IFN-ω at baseline. Most patients with CTLA-4 insufficiency and COVID-19 had nonsevere disease, lacked autoantibodies against type 1 IFNs, and tolerated messenger RNA vaccines with few adverse effects. Whether our findings can be extrapolated to patients receiving CTLA-4-targeting checkpoint inhibitors requires further studies.
Vibrio-Sequins - dPCR-traceable DNA standards for quantitative genomics of Vibrio spp
Authors: Flütsch Sabrina , Wiestner Fabian , Butticaz Lisa , Moor Dominik , Stölting Kai N. 
Published: July 2023

Abstract
Background
Vibrio spp. are a diverse group of ecologically important marine bacteria responsible for several foodborne outbreaks of gastroenteritis around the world. Their detection and characterization are moving away from conventional culture-based methods towards next generation sequencing (NGS)-based approaches. However, genomic methods are relative in nature and suffer from technical biases arising from library preparation and sequencing. Here, we introduce a quantitative NGS-based method that enables the quantitation of Vibrio spp. at the limit of quantification (LOQ) through artificial DNA standards and their absolute quantification via digital PCR (dPCR).

Results
We developed six DNA standards, called Vibrio-Sequins, together with optimized TaqMan assays for their quantification in individually sequenced DNA libraries via dPCR. To enable Vibrio-Sequin quantification, we validated three duplex dPCR methods to quantify the six targets. LOQs were ranging from 20 to 120 cp/µl for the six standards, whereas the limit of detection (LOD) was ~ 10 cp/µl for all six assays. Subsequently, a quantitative genomics approach was applied to quantify Vibrio-DNA in a pooled DNA mixture derived from several Vibrio species in a proof-of-concept study, demonstrating the increased power of our quantitative genomic pipeline through the coupling of NGS and dPCR.

Conclusions
We significantly advance existing quantitative (meta)genomic methods by ensuring metrological traceability of NGS-based DNA quantification. Our method represents a useful tool for future metagenomic studies aiming at quantifying microbial DNA in an absolute manner. The inclusion of dPCR into sequencing-based methods supports the development of statistical approaches for the estimation of measurement uncertainties (MU) for NGS, which is still in its infancy.
Effects of reminiscence therapy on quality of life and life satisfaction of the elderly in the community: a systematic review
Authors: Shin Eunyoung , Kim Myeongshin , Kim Seyoon , Sok Sohyune 
Published: July 2023

Abstract
Background
Reminiscence therapy is known as an effective intervention method for elderly with various health conditions. This study was to provide basic data for contributing to the spread and development of effective intervention by analyzing the characteristics and effects of reminiscence therapy applied to the elderly at home.

Methods
To select the article to be studied, literature published from January 2000 to January 2021 was searched through eight databases. A total of 897 articles were searched, and the collected papers were analyzed using the flow chart of Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Of these, 6 articles suitable for the selection criteria were selected by reviewing titles and abstracts, excluding duplicate papers, using EndNote X9 and Excel 2013. The quality of literature was evaluated using the critical appraisal checklist of the Joanna Briggs Institute.

Results
For the characteristics of the selected literature, most of the literature published within the last 10 years was conducted, and the research design was conducted only in experimental research. The most common form of reminiscence therapy was group reminiscence, and the type was ‘simple reminiscence’. The intervention method of reminiscence therapy was provided in various ways, but ‘Sharing’ was mainly used, and the representative topic of recall was ‘Hometown’. Most of the intervention was performed less than 10 times and took about 60 min.

Conclusion
According to the results of this study, reminiscence therapy provided to the elderly living in the community was effective in improving their quality of life and life satisfaction. Therefore, it is suggested that reminiscence therapy can be an intervention method that is helpful for positive psychological factors and health promotion by improving the quality of life and life satisfaction of the elderly living in the community, and further, it is considered that the elderly can contribute to non-pharmacologically healthy aging in the community.