bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes Up to Age 36 Months after Congenital Zika Virus Infection – U.S. States
Authors: Neelam Varsha , Woodworth Kate R. , Chang Daniel J. , Roth Nicole M. , Reynolds Megan R. , Akosa Amanda , Carr Christopher P. , Anderson Kayla N. , Mulkey Sarah B. , DeBiasi Roberta L. , Biddle Cara , Lee Ellen H. , Elmore Amanda L. , Scotland Sarah J. , Sowunmi Similoluwa , Longcore Nicole D. , Ahmed Muhammad , Langlois Peter H. , Khuwaja Salma , Browne Shea Elizabeth , Lind Leah , Shim Kyoo , Gosciminski Michael , Blumenfeld Rachel , Khuntia Shreya , Halai Umme-Aiman , Locklear Autumn , Chan Mary , Willabus Teri' , Tonzel Julius , Marzec Natalie S. , Barreto Nianest Alers , Sanchez Connie , Fornoff Jane , Hale Shelby , Nance Amy , Adibhatla Sowmya N. , Potts Emily , Schiffman Elizabeth , Raman Devin , McDonald Morgan F. , Stricklin Brandi , Ludwig Elizabeth , Denson Lindsay , Contreras Dianna , Romitti Paul A. , Ferrell Emily , Marx Meghan , Signs Kimberly , Cook Amie , Beauregard Suzann , Orantes Lucia C. , Cronquist Laura , Roush Lesley , Godfred-Cato Shana , Gilboa Suzanne M. , Meaney-Delman Dana , Honein Margaret A. , Moore Cynthia A. , Tong Van T. 
Published: July 2023

Abstract
Background:
To characterize neurodevelopmental abnormalities in children up to 36 months of age with congenital Zika virus exposure.
Methods:
From the U.S. Zika Pregnancy and Infant Registry, a national surveillance system to monitor pregnancies with laboratory evidence of Zika virus infection, pregnancy outcomes and presence of Zika associated birth defects (ZBD) were reported among infants with available information. Neurologic sequelae and developmental delay were reported among children with ≥ 1 follow-up exam after 14 days of age or with ≥ 1 visit with development reported, respectively.
Results:
Among 2,248 infants, 10.1% were born preterm, and 10.5% were small-for-gestational age. Overall, 122 (5.4%) had any ZBD; 91.8% of infants had brain abnormalities or microcephaly, 23.0% had eye abnormalities, and 14.8% had both. Of 1,881 children ≥ 1 follow-up exam reported, neurologic sequelae were more common among children with ZBD (44.6%) vs. without ZBD (1.5%). Of children with ≥ 1 visit with development reported, 46.8% (51/109) of children with ZBD and 7.4% (129/1739) of children without ZBD had confirmed or possible developmental delay.
Conclusion:
Understanding the prevalence of developmental delays and healthcare needs of children with congenital Zika virus exposure can inform health systems and planning to ensure services are available for affected families.
Machine learning of the patient characteristics and of vascular features observed on pre-procedural computed tomography angiographs helps to predict endovascular leaks after thoracic endovascular aneurysm repair
Authors: Masuda Takanori , Baba Yasutaka , Nakaura Takeshi , Funama Yoshinori , Sato Tomoyasu , Masuda Shouko , Gotanda Rumi , Arao Keiko , Imaizumi Hiromasa , Arao Shinichi , Ono Atsushi , Hiratsuka Junichi , Awai Kazuo 
Published: July 2023

Abstract

Purpose:
To predict endoleaks after thoracic endovascular aneurysm repair (TEVAR) we submitted patient characteristics and vessel features observed on pre- operative computed tomography angiography (CTA) to machine-learning.
Methods:
We evaluated 1-year follow-up CT scans (arterial and delayed phases) in
patients who underwent TEVAR for the presence or absence of an endoleak. We evaluated the effect of machine learning of the patient age, sex, weight, and height, plus 22 vascular features on the ability to predict post-TEVAR endoleaks. The extreme Gradient Boosting (XGBoost) for ML system was trained on 14 patients with- and 131 without endoleaks. We calculated their importance by applying XGBoost to machine learning and compared our findings between with those of conventional vessel measurement-based methods such as the 22 vascular features by using the Pearson correlation coefficients.
Results:
Pearson correlation coefficient and 95% confidence interval (CI) were r = 0.86 and 0.75 to 0.92 for the machine learning, r = -0.44 and – 0.56 to -0.29 for the vascular angle, and r = -0.19 and -0.34 to -0.02 for the diameter between the subclavian artery and the aneurysm (Fig. 3a-3c, all: p < 0.05). With machine-learning, the univariate analysis was significant higher compared with the vascular angle and in the diameter between the subclavian artery and the aneurysm such as the conventional methods (p < 0.05).
Conclusions:
To predict the risk for post-TEVAR endoleaks, machine learning was superior to the conventional vessel measurement method when factors such as patient characteristics, and vascular features (vessel length, diameter, and angle) were evaluated on pre-TEVAR thoracic CTA images.
Comparative Cohort Study of Post-Acute Covid-19 Infection with a Nested, Randomized Controlled Trial of Ivabradine for Those With Postural Orthostatic Tachycardia Syndrome (The COVIVA Study)
Authors: Saunders David , Arnold Thomas B. , Lavender Jason M. , Bi Daoqin , Alcover Karl , Hellwig Lydia D. , Leazer Sahar T , Mohammed Roshila , Markos Bethelhem , Perera Kanchana , Shaw Dutchabong , Kobi Priscilla , Evans Martin , Mains Autumn , Tanofsky-Kraff Marian , Goguet Emilie , Mitre Edward , Pratt Kathleen P , Dalgard Clifton L , Haigney Mark C 
Published: July 2023

Abstract
Background: Significant clinical similarities have been observed between the recently described ‘Long-Haul’ COVID-19 (LHC) syndrome, Postural Orthostatic Tachycardia Syndrome (POTS) and Inappropriate Sinus Tachycardia (IST). Shared symptoms include light-headedness, palpitations, tremulousness, generalized weakness, blurred vision, chest pain, dyspnea, “brain-fog”, and fatigue. Ivabradine is a selective sinoatrial node blocker FDA-approved for management of tachycardia associated with stable angina and heart failure not fully managed by beta blockers. In our study we aim to identify risk factors underlying LHC, as well as the effectiveness of ivabradine in controlling heart rate dysregulations and POTS/IST related symptoms.
Methods/Design: A detailed prospective phenotypic evaluation combined with multi-omic analysis of 200 LHC volunteers will be conducted to identify risk factors for autonomic dysfunction. A comparator group of 50 volunteers with documented COVID-19 but without LHC will be enrolled to better understand the risk factors for LHC and autonomic dysfunction. Those in the cohort who meet diagnostic criteria for POTS or IST will be included in a nested prospective, randomized, placebo-controlled trial to assess the impact of ivabradine on symptoms and heart rate, assessed non-invasively based on physiologic response and ambulatory electrocardiogram. Additionally, studies on catecholamine production, mast cell and basophil degranulation, inflammatory biomarkers, and indicators of metabolic dysfunction will be measured to potentially provide molecular classification and mechanistic insights.
Discussion: Optimal therapies for dysautonomia, particularly associated with LHC, have yet to be defined. In the present study, ivabradine, one of numerous proposed interventions, will be systematically evaluated for therapeutic potential in LHC-associated POTS and IST. Additionally, this study will further refine the characteristics of the LHC-associated POTS/IST phenotype, genotype and transcriptional profile, including immunologic and multi-omic analysis of persistent immune activation and dysregulation. The study will also explore and identify potential endotheliopathy and abnormalities of the clotting cascade.
Trial registration:ClinicalTrials.gov, ID:NCT05481177 Registered on 29 July 2022.
The Impact and Prediction of Industrial Structure on the Reduction of Pollution and Carbon Emissions: A Case Study of the Yellow River Basin in China
Authors: Liu Jianhua , Shi Tianle , huang liangchao , Wang Huiyang 
Published: July 2023

Abstract
By analyzing the mechanism by which industrial structure adjustment influences the reduction in pollution and carbon emissions (RPCE) in the Yellow River Basin, in this study, we calculated data for the RPCE in 57 prefecture-level cities from 2011 to 2020. Based on the Regression on Population, Affluence, and Technology (STIRPAT) model, we empirically examined factors affecting the RPCE in the Yellow River Basin. Additionally, different scenarios were established in order to simulate and predict the future trend of the RPCE in the Yellow River Basin. In the study, we found the following: (1) The RPCE in the Yellow River Basin shows a positive trend, with lower levels in upstream Gansu and Ningxia and particularly severe conditions in Zhongwei, Shizuishan, and Wuhai, making these key areas for RPCE. (2) Moreover, the RPCE effect of the advanced industrial structure in the Yellow River Basin is superior to that of the rationalized industrial structure, economic growth and population increases are conducive to RPCE, foreign investors in the Yellow River Basin tend to invest more in high-energy-consuming industries, and there is a “pollution haven” effect. (3) In terms of regional heterogeneity, the impact of industrial structure adjustment on the RPCE in the lower and middle reaches is greater than that in the upstream regions. (4) The acceleration of the transformation and upgrading of industry, stabilization of the population growth rate, and promotion of high-quality economic development are the optimal development paths for RPCE in the Yellow River Basin.
Determinants of Iron Deficiency Anaemia among non-pregnant women of reproductive age in Malawi: A cross sectional study
Authors: Chiwaya Andrew , Stones William , Singano Chisomo 
Published: July 2023

Abstract
In Malawi, the prevalence of Iron Deficiency Anaemia (IDA) among women of reproductive age is 8%. There is lack of up-to-date information on factors associated with IDA among women of reproductive age in Malawi. This cross sectional study aimed at identifying factors that are associated with IDA among non-pregnant women of reproductive age in Malawi using secondary data from the Malawi Micronutrient Survey, a sub study of the Malawi Demographic and Health Survey, 2015-16. A total of 751 non-pregnant women aged 15–49 years were included in the final analysis. Univariate and multivariate logistic regression analysis were carried to analyse the data. The study found IDA prevalence of 7.19% and was statistically associated with age of the woman, type of residence (rural/urban), contraceptive use, BMI, and region. In the multivariate analysis, age (40–49) years (OR = 4.37, CI = 1.72–11.09) was significantly associated with increased odds of IDA while rural residence (OR = 0.29, CI = 0.14–0.57), using injectable contraceptives (OR = 0.18, CI = 0.05–0.64), and overweight (OR = 0.48, CI = 0.16–1.40) showed a protective effect against IDA. There is need to scale up family planning services especially use of injectables. Women living in urban areas should be encouraged to consume food rich in iron. Health education on nutrition and dietary modification should be fostered.
Unveiling Liquid-Crystalline Lipids in the Urothelial Membrane through Cryo-EM
Authors: Oda Toshiyuki , Yanagisawa Haruaki , Kikkawa Masahide , KITA YOSHIHIRO 
Published: July 2023

Abstract
The urothelium, a distinct epithelial tissue lining the urinary tract, serves as an essential component in preserving urinary tract integrity and thwarting infections. The asymmetric unit membrane (AUM), primarily composed of the uroplakin complex, constitutes a critical permeability barrier in fulfilling this role. However, the molecular architectures of both the AUM and the uroplakin complex have remained enigmatic due to the paucity of high-resolution structural data. In this investigation, we employed cryo-electron microscopy to elucidate the three-dimensional structure of the uroplakin complex embedded within the porcine AUM at a resolution of 3.5 Å. Our findings unveiled that the uroplakin complexes are situated within hexagonally arranged crystalline lipid membrane domains, rich in hexosylceramides. Moreover, our research rectifies a misconception in a previous model by confirming the existence of a domain initially believed to be absent, and pinpointing the accurate location of a crucial Escherichia coli binding site implicated in urinary tract infections. These discoveries offer valuable insights into the molecular underpinnings governing the permeability barrier function of the urothelium and the orchestrated lipid phase formation within the plasma membrane.
Low-cost augmented reality goggles enable precision fluorescence-guided cancer surgery
Authors: Shmuylovich Leonid , O'Brien Christine , Nwosu Karen , Achilefu Samuel 
Published: July 2023

Abstract

Disparities in surgical outcomes often result from subjective than objective decisions dictated by surgical training, experience, and available resources. To improve outcomes, surgeons have adopted advancements in robotics, endoscopy, and intra-operative imaging including fluorescence-guided surgery (FGS), which highlight tumors in real-time without using ionizing radiation. However, like many medical innovations, technical, economic, and logistic challenges have hindered widespread adoption of FGS beyond high-resource centers. To overcome these impediments, we developed the fully-wearable and battery-powered fluorescence imaging augmented reality Raspberry Pi-based goggle system (FAR-Pi). Novel device design ensures distance-independent coalignment between real and augmented FAR-Pi views and offers higher spatial resolution, depth of focus, and fluorescence detection sensitivity than existing bulkier, pricier, and wall-powered technologies. When paired with pan-tumor targeting fluorescent agents such as LS301, FAR-Pi objectively identifies tumors in vivo. As an open-source, affordable, and adaptable system, FAR-Pi is poised to democratize access to FGS and improve health outcomes worldwide.
Novel Waterborne polymeric Crosslinkers Containing Blocked Isocyanate Moieties and Active Epoxy Groups for Electrophoretic Coatings
Authors: Zhou Ben , Cao Yuting , Lu Shuaiwei , Wei Jun 
Published: July 2023

Abstract
The epoxy intermediates with three hydroxyl groups were synthesized from 2-aminoethanol (ETA) with ethylene glycol diglycidyl ether (EGDE) or resorcinol diglycidyl ether (RDGE), followed by the neutralization of the inherent tertiary amine groups. The intermediate was then reacted with isophorone diisocyanate (IPDI) to produce polyurethane prepolymer, which was further chain-extended and modified by polyethylene glycol (PEG-1000) and polyethylene glycol monomethyl ether (MPEG-1200), respectively. Finally, methyl ethyl ketone oxime (MEKO) was used to block the residual isocyanate (NCO) group, leading to the achievement of the waterborne polymeric crosslinkers containing blocked NCO moieties and active epoxy groups. The structure of the crosslinkers was characterized by Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance hydrogen spectroscopy (1H-NMR). The thermal properties of the crosslinkers were studied by TG and DTG. The mechanical properties of the cured films obtained by applying crosslinkers to electrophoretic coatings were also studied. The results indicate that the introduction of epoxy groups has a significant effect on the mechanical properties of the cured films, and the RGDE crosslinker system is the optimal selection.
Is breastfeeding during the Covid-19 pandemic too close for comfort?
Authors: Hackenbruch Sophie Noelle , Cutajar Daniel , Farrugia Ryan Dominic 
Published: July 2023

Abstract

Purpose
This study aims to assess whether Covid-19 has affected breastfeeding rates negatively in the Maltese neonatal population and how breastfeeding services have been impacted by the pandemic. Data was also compared to a nationwide study carried out in 2008 to assess whether any improvements in breastfeeding rates and service have been made.
Methods
It is a retrospective cohort study which used a questionnaire to obtain its data.
The study was carried out in Mater Dei Hospital, the only local government hospital that serves as the main hospital of the island. Data of every birth in Mater Dei Hospital during the period August and September 2019 as well as August and September 2020 was collected and compared. This allowed the comparison of newborns up to 6 months of age prior to the first reported case of COVID-19 on the Maltese (7th March 2020) islands to newborns born during the COVID-19 pandemic. Data of each birth was collected from the Malta Birth Registry. Legal guardians of the child werecontacted via phone and asked to give verbal consent. Only authorised researchers contacted the caregivers.
Results
A total of 1481 mothers gave birth during August and September 2019 and 2020, of which 734 (50%) were in 2019 and 747 (50%) in 2020. Out of these 235 (32%) caregivers were reached in the pre-covid cohort and 228 (30%) in the covid cohort. During the Covid 19 pandemic mothers-to-be were significantly less likely to be informed of the services offered by Mater Dei Hospital, with 13% being informed of the services compared to 83% of mothers in the pre covid cohort (P<0.000). During the covid-19 pandemic 36% (n=83) of mothers continued breastfeeding until 6 months of age compared to 3% (n=6) pre covid pandemic.
Conclusions
Despite breastfeeding protocols, ambitions to become a baby friendly hospital and increased staff awareness to breastfeeding the general population is evidently not convinced. Covid-19 did not have a negative impact on the attrition rates in the Maltese population despite poorer health care services, however it did increased breastfeeding rates at 6 months of age. Community services and hospital services need to be improved to improve the poor breastfeeding rate on the Maltese islands. Increased awareness of breastfeeding in the workplace and in public areas would beneficial. Pre and postnatal education in the hospital environment should be enhanced.
Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain
Authors: Waites Clarissa , Yu Qing , Du Fang , Belli Irla , Gomes Patrícia , Sotiropoulos Ioannis 
Published: July 2023

Abstract
Chronic stress and elevated levels of glucocorticoids (GCs), the main stress hormones, accelerate Alzheimer’s disease (AD) onset and progression. A major driver of AD progression is the spreading of pathogenic Tau protein between brain regions, precipitated by neuronal Tau secretion. While stress and high GC levels are known to induce intraneuronal Tau pathology (i.e. hyperphosphorylation, oligomerization) in animal models, their role in trans-neuronal Tau spreading is unexplored. Here, we find that GCs promote secretion of full-length, vesicle-free, phosphorylated Tau from murine hippocampal neurons and ex vivo brain slices. This process occurs via type 1 unconventional protein secretion (UPS) and requires neuronal activity and the kinase GSK3b. GCs also dramatically enhance trans-neuronal Tau spreading in vivo, and this effect is blocked by an inhibitor of Tau oligomerization and type 1 UPS. These findings uncover a potential mechanism by which stress/GCs stimulate Tau propagation in AD.
Attacking cryptosystems by means of Virus Machines
Authors: Ramírez-de-Arellano Antonio , Orellana-Martín David , Pérez-Jiménez Mario J. 
Published: July 2023

Abstract
The security that resides in the public-key cryptosystems relies on the presumed computational hardness of mathematical problems behind the systems themselves (e.g. the semiprime factorization problem in the RSA cryptosystem), that is because there is not known any polynomial time (classical) algorithm to solve them. The paper focuses on the computing paradigm of virus machines within the area of Unconventional Computing and Natural Computing. Virus machines, which incorporate concepts of virology and computer science, are considered as number computing devices with the environment. The paper designs a virus machine that solves a generalization of the semiprime factorization problem and verifies it formally.
Investigation of the association between polymorphisms in DNA repair enzymes and STEMI
Authors: Guven Mehmet , Citak Elif , Malikova Narmina , Koca Damla , Durmaz Eser 
Published: July 2023

Abstract
Background: STEMI (ST-elevation myocardial infarction) is one of the most severe forms of coronary artery disease, known to significantly contribute to DNA damage. There are very few publications in this field in the literature. In our study, we examined the association between four polymorphisms in repair enzymes (LIG4 Thr9Ile, XRCC6 promoter C-57G, XPA -4A/G, OGG1 Ser326Cys) involved in three distinct DNA repair mechanisms (NHEJ (non-homologous end joining), NER (nucleotide excision repair), and BER (base excision repair), and their impact on the risk of STEMI.
Methods & Results: This study involved 185 patients diagnosed with STEMI and included 100 healthy controls. The genotyping of SNPs was conducted through the PCR-RFLP (Polymerase chain reaction-restriction fragment length polymorphism) method for the following variants: XRCC6 (rs2267437), XPA (rs1800975), LIG4 ( rs1805388), and OGG1 (rs1052133). No significant differences were observed in the genotype distributions of the XRCC6 and OGG1 variations between the control and patient groups. On the other hand, our findings indicate that individuals carrying the mutant G allele for XPA polymorphism and the mutant Tallele for LIG4 polymorphism are susceptible to STEMI.
Conclusions: Our findings demonstrate the significance of NHEJ and NER DNA repair processes in the pathogenesis of STEMI, as evidenced by the observed relationship between LIG4 and XPA polymorphisms.
Hypersensitive C-reactive Protein as a Potential Indicator for Predicting Left Ventricular Hypertrophy in Elderly Community-Dwelling Patients with Hypertension
Authors: song wei , Zhang Chunsheng , Tang Jiamei , Li Yan , Jiao Tiantian , Lin Xueqi , Wang Yuanqi , Fang Jialiang , Sha Jingjing , Ding Tongjiu , Cheng Jiayue , Li Jiming 
Published: July 2023

Abstract
BACKGROUND
The aim of this study was to investigate the relationship between Hypersensitive C-reactive protein (hs-CRP) and left ventricular hypertrophy (LVH) in elderly patients with hypertension in the community.
METHODS
A prospective study was conducted, involving the recruitment of 365 elderly hypertensive residents from five communities. The participants were divided into two groups: an LVH group (n=134) and a non-LVH group (n=231), based on the left ventricular mass index (LVMI) determined by echocardiography. Spearman correlation analysis was used to assess the relationship between hs-CRP and LVH. Univariate and Multivariate analysis was performed to detect variables associated with LVH. The diagnostic value of hs-CRP for LVH was expressed as the area under the receiver operating characteristic (ROC) curve.
RESULTS
The incidence of LVH in elderly hypertension patients in the community was 36.7%. The hs-CRP levels were significantly higher in subjects with LVH compared to those without LVH (1.9 [0.8, 2.9] vs. 0.7 [0.4, 1.4], P=0.002). Spearman correlation analysis demonstrated a positive correlation between hs-CRP and LVMI (r=0.246, P<0.001), as well as with IVST (r=0.246, P<0.001) and LVPWT (r=0.172, P=0.001). Among elderly hypertensive residents in the community, the cut-off value of hs-CRP for diagnosing LVH was 1.25 mg/L (sensitivity: 57.5%; specificity: 78.4%), and the area under the ROC curve for hs-CRP to predict LVH was 0.710 (95%CI: 0.654-0.766; P<0.001). After adjusting for various confounding factors, the multivariate logistic regression model revealed that hs-CRP levels ≥1.25 mg/L were independent risk factors for the development of LVH (OR=3.490; 95%CI, 2.097-5.809; P<0.001).
CONCLUSIONS
This community-based cohort of elderly hypertensive individuals demonstrates a strong association between hs-CRP levels and the presence of LVH. The hs-CRP ≥1.25 mg/L may serve as an independent predictor for LVH in hypertensive subjects and exhibit good diagnostic efficacy for LVH.