bluuebunny/crossref_metadata_2025_split huggingface dataset:
An updated overview of the application of CAR‐T cell therapy in neurological diseases
Authors: Shahabifard Hesam , Zarei Mahdi , Kookli Keihan , Esmalian Afyouni Nazgol , Soltani Narges , Maghsoodi Sairan , Adili Ali , Mahmoudi Javad , Shomali Navid , Sandoghchian Shotorbani Siamak 
Published: May 2023

AbstractGenetically modified immune cells, especially CAR‐T cells, have captured the attention of scientists over the past 10 years. In the fight against cancer, these cells have a special place. Treatment for hematological cancers, autoimmune disorders, and cancers must include CAR‐T cell therapy. Determining the therapeutic targets, side effects, and use of CAR‐T cells in neurological disorders, including cancer and neurodegenerative diseases, is the goal of this study. Due to advancements in genetic engineering, CAR‐T cells have become crucial in treating some neurological disorders. CAR‐T cells have demonstrated a positive role in treating neurological cancers like Glioblastoma and Neuroblastoma due to their ability to cross the blood–brain barrier and use diverse targets. However, CAR‐T cell therapy for MS diseases is being researched and could be a potential treatment option. This study aimed to access the most recent studies and scientific articles in the field of CAR‐T cells in neurological diseases and/or disorders.
Volatile Oil Yield and Composition, Total Phenolic Content, Antioxidant Activity and Secondary Metabolite Content of Collected Thymus praecox Species in Rize
Authors: Yurteri Emine 
Published: May 2023

AbstractIn this study, the volatile oil yield (Clevenger), volatile oil (VO) composition (Gas Chromatography), phenolic contents (UV‐VIS Spectrophotometer), antioxidant activities (UV‐VIS Spectrophotometer) and secondary metabolite content (High Pressure Liquid Chromatography) of 11 Thymus praecox subspecies were evaluated. The most detected chemical class were oxygenated monoterpenes (55.18–86.1 %) in investigated samples. In the present study rosmarinic acid, isoquercitrin, gallocatechin and thymol could be detected in high amounts. The min. and max. content values of Flora/Field Samples were 1543.241 and 890.3‐1425.3 for rosmarinic acid, 139.44‐287.894 and 129.9‐312.2 for thymol, 38.619‐121.424 and 26.3‐112.9 for gallocatechin as mg/g DW. Principal Component Analysis was used to differentiate Thymus praecox species regarding volatile oil composition and secondary metabolite content. The results demonstrated that T. praecox collected from the Rize flora and cultivated afterwards showed variability based on investigated characteristics. Finally, the Thymus praecox samples displaying high bioactive compounds present useful information for further investigations and applications.
Preoperative simulation using three‐dimensional printer in four temporal bone surgeries
Authors: Fukumoto Ichiro , Mita Yukiyoshi , Shimmi Rie , Sonobe Yuri , Iinuma Tomohisa , Yamasaki Kazuki , Yonekura Shuji , Nemoto Toshimitsu , Hanazawa Toyoyuki 
Published: May 2023

AbstractPreoperative simulation using a three‐dimensional printer is effective to perform safe surgery by knowing the range limit of drilling in the temporal bone. Moreover, simulations using models are thought to be useful for education of young surgeon.
A report of two cases with successful oocyte retrieval after wrongly earlier injection of ovulation induction trigger: Case report
Authors: Kabodmehri Roya , Sharami Seyedeh Hajar , Ghanami Gashti Nasrin , Hadi Bahadori Mohammad , Zahiri Sorouri Ziba 
Published: May 2023

AbstractOocyte maturation is induced by trigger administration and is acritical step in the success of assisted reproductive technology (ART)treatment. The ideal time interval between trigger administration and oocyte retrieval varies in the literature. Extremely short or long time intervals are both knownto cause unfavorable outcomes in oocyte collection. Accurate control over theinterval between trigger injection and oocyte retrieval is very important forwomen undergoing in vitro fertilization (IVF), to avoid unexpected premature ovulation.In this report, we present two infertile women who mistakenly injected the triggering dose of gonadotropin releasing hormone agonist (GnRHa) 12 h earlier. Case 1 and case 2 were 23 and 30 years old, respectively. Therewas no intervention to prevent pre‐operative ovulation, and oocyte retrievalhas been done 48–50 h after trigger injection. oocytes and embryos quality wereacceptable.In conclusion, in patients who have the wrong trigger injection, oocyte retrieval is recommended after consulting the patient about theadvantages and disadvantages of the oocyte retrieval operation.
Unusual presentation of acquired thrombotic thrombocytopenic purpura (TTP) versus catastrophic antiphospholipid syndrome in a patient with Moya‐Moya disease, case report, and literature review
Authors: Guevara‐Rodriguez Nehemias , Marmanillo‐Mendoza Gabriela , Castelar Jorge , Ciobanu Camelia , Fulger Ilmana 
Published: May 2023

Key Clinical MessageCoincidences in medicine are not so common. We are presenting a case of a patient diagnosed with Moya‐Moya disease and antiphospholipid syndrome (APS) who presented with clinical and laboratory characteristics of catastrophic APS versus TTP. The diagnosis was a challenge because characteristics were overlapping. Nevertheless, a decision to treat the patient for TTP was made with afterward improvement. MMD has been associated with multiple immune disorders; however, only one case of acquired thrombotic thrombocytopenic purpura has been documented in association with this disease. None has been associated with catastrophic antiphospholipid syndrome. We are presenting a challenging case where all these three medical conditions were present at the same time.
A rare case of concurrent pneumonia, rib osteomyelitis, spondylodiscitis, paravertebral and epidural abscesses in a patient with chronic granulomatous disease
Authors: Tavakolizadeh Nahid , Ahmadzade Amir Mahmoud , Beizaei Behnam , Izanlu Mostafa , Khoroushi Farzaneh , Aminzadeh Behzad 
Published: May 2023

AbstractChronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder that is characterized by deficiencies in the phagocytes capacity to eliminate ingested microorganisms, which frequently causes bacterial and fungal infections. The extensive involvement of the lungs, ribs, and vertebrae that is complicated by multiple abscesses from aspergillosis is rare. in this study, we report a 13‐year‐old boy with CGD who experienced concurrent pneumonia, rib osteomyelitis, spondylodiscitis, paravertebral, and epidural abscesses as a result of Aspergillus flavus infection with associated computed tomography scan and magnetic resonance imaging findings. Patients with CGD are susceptible to Aspergillus infection. Correct diagnosis based on clinical and paraclinical findings as well as choosing the best treatment regimen is essential for achieving a favorable outcome.
Construction of a Novel TiO2‐Covalent‐Organic‐Framework Heterojunction for Highly Selective Photo‐Oxidation Coupling of Amines under Visible Light Irradiation
Authors: Zhou Li , Huang Zezhao , Zhang Hao , Gao Huanjie , Tang Jiameng , Yao Xiaoquan 
Published: May 2023

AbstractA novel heterojunction material constructed with titanium dioxide nanoparticles and covalent organic frameworks, TiO2@COF‐5 NPs, was designed and synthesized successfully from HHTP, PBBA and TiO2 under solvothermal conditions. Notably, the TiO2@COF‐5 heterojunction demonstrated excellent photocatalytic performance for the aerobic oxidative coupling reaction of benzylamines to N‐benzyl‐1‐phenyl methanimines under visible light irradiation, and both high conversions (up to 99 %) and high selectivity (99 %) were achieved for various benzylamines. The ameliorated photocatalytic performance might owe much to establishing the systematic coupling between the TiO2 nanoparticles and covalent organic frameworks, which could effectively extend the wavelength range of visible light absorption and increase more reactive active sites. This study might provide a versatile approach to combining covalent organic frameworks with inorganic semiconductors to give full play to the synergistic effect of catalysis.
Dipole‐Transmissive 1,3‐Dipolar Cycloadditions for the Rapid Construction of Polycyclic N‐Heterocycles: Synthetic and Mechanistic Investigations
Authors: Henneveld Jackson S. , Shiri Farshad , Ariafard Alireza , Lucas Nigel T. , Bissember Alex C. , Hawkins Bill C. 
Published: May 2023

AbstractThe investigation of distinctive dipole‐transmissive dipolar cycloaddition (DTDC) methodology and the formalisation of this concept is reported. A DTDC procedure was able to be developed by taking advantage of the structural complementarity of azide and diazoalkane 1,3‐dipoles. Intramolecular azide‐alkene 1,3‐DCs followed by spontaneous dipole transmission upon work‐up furnished intermediate α‐diazoisoindole and α‐diazoisoquinoline substrates bearing the key secondary diazoalkane 1,3‐dipole. N‐Derivatisation of the intermediate α‐diazoisoindole and α‐diazoisoquinolines with a tethered secondary dipolarophile followed by a subsequent 1,3‐DC allowed for rapid construction of a range of functionalised polycyclic N‐heterocycles. Integrated experimental and theoretical studies established requirements for product formation and revealed the likely mechanistic basis of divergent reactivity observed.
Light‐Driven Dinitrogen Activation with Transition Metal Complexes: Mechanisms and Applications†
Authors: Zhao Xuan‐Xuan , Wei Junnian , Xi Zhenfeng 
Published: May 2023

Comprehensive SummaryThe Haber‐Bosch process, which is used for ammonia (NH3) synthesis, requires vast amounts of energy, accounting for approximately 1%—2% of the world's annual energy consumption. Therefore, researchers in both industry and academia are interested in developing sustainable and environmentally friendly methods for synthesizing nitrogenous compounds at ambient conditions using renewable energy sources such as visible light. While several examples of thermal activation of dinitrogen molecules have been demonstrated using various transition metals and ligand frameworks, the use of light to weaken or split the strong N—N bond has been less explored. This article presents an overview of molecular complexes capable of dinitrogen photocleavage and provides mechanistic insights into the photoactivation process through experimental and theoretical studies. We believe this review will provide readers with an in‐depth understanding of the current state‐of‐the‐art and future research perspectives, particularly in the use of visible light for dinitrogen activation and transformation.
PROTOCOL: Group‐based interventions for posttraumatic stress disorder: A systematic review and meta‐analysis of the role of trauma type
Authors: Griffin Siobhán M. , Lebedová Alžběta , Ahern Elayne , McMahon Grace , Bradshaw Daragh , Muldoon Orla T. 
Published: May 2023

AbstractThis is the protocol for a Campbell systematic review. The primary objective is to assess the effects of group‐based treatments on posttraumatic stress disorder (PTSD) symptomology in people diagnosed with PTSD (by a clinician or screening instrument) or referred to a PTSD treatment group for their symptoms by a medical professional. We will also examine a range of moderators that may affect the efficacy of group‐based treatments, including the nature of the trauma (interpersonal, stigmatized) and the group fit (in terms of gender and shared vs. unshared trauma). Further, we will also explore what, if any, group‐based and social identity factors are recorded and how they relate to PTSD outcomes.
The climate change, conflict and migration nexus: A holistic view
Authors: Watson Tabitha , Lenton Tim , de Campos Ricardo Safra 
Published: May 2023

AbstractCurrent discourse relating to climate change, conflict, migration (CCM), and the causal links thereof, is polarized. It is widely acknowledged that climate change will have a detrimental effect on quality of life, and that this impact will not be homogeneous across the globe. However, proposed causal links among CCM remain contentious. This paper argues that to better grasp the implications of climate change on global society and security, it is vital to develop a more systemic understanding of the interplay among CCM. Although this nexus is already recognized, studies to date have tended to be qualitative and statistical evidence of multivariate causality has been lacking, where quantitative analysis is present, it has typically been limited to two components at a time; few studies have addressed the nexus holistically, making research conclusions sometimes difficult to reconcile. Hence, by reviewing literature from a broad range of sources, this paper suggests a suite of systemic and quantitative approaches with which to address the CCM nexus. This review critically assesses the existing research approaches employed across a range of examples and suggests how leveraging the power of ‘big data’ and modelling the nexus as a complex system encapsulating both human and environmental drivers could offer new insights, especially for those looking to explore the increasing number of ‘what if’ scenarios relating to climate and human dynamics.
The use of patient‐reported outcome measures by healthcare professionals in specialized asthma management centers in French‐speaking Belgium: A mixed‐methods study
Authors: Louis Gilles , Voz Bernard , Guillaume Michèle , Kirkove Delphine , Pétré Benoit 
Published: May 2023

AbstractIntroductionRecently, the literature has promoted the use of patient‐reported outcome measures (PROMs) in clinical practice as a means to foster patient engagement. However, conditions necessary to support the use of PROMs to encourage asthma patient engagement are not clearly defined. Therefore, we sought (1) to explore the current and ideal use of PROMs by healthcare professionals (HP) in specialized asthma management centers in French‐speaking Belgium and (2) to understand under which conditions the use of PROMs contributes to patient engagement.MethodsWe undertook a mixed‐methods study with both anonymous online survey and in‐person qualitative semi‐structured interviews conducted with HPs to understand their perspectives on the routine use of PROMs. HPs were recruited from 16 asthma centers (French‐speaking Belgium) identified via the Belgian Respiratory Society.ResultsOf the 170 HPs identified from the 16 participating centers, 51 (30%) responded to the survey (n = 51) and 11 completed semi‐structured interviews. 53% (27/51) of the surveyed HPs reported using PROMs primarily for asthma monitoring and clinical research while all reported that PROMs should primarily be used in practice to facilitate communication with the patient and to address neglected aspects of the care relationship such as the psychosocial aspects of the disease. The qualitative interviews revealed avenues for moving from a medical‐centered and utilitarian use of PROMs to a use serving patient engagement. This would require HPs to go beyond their current representation of PROMs, to use instruments offering a more holistic image of the patient, to incorporate PROMs into a digital tool and to integrate PROMs in a patient education process.ConclusionThe main findings of this study suggest relevant avenues for using PROMs in ways that support patient engagement.
Radiation‐induced sarcomas following childhood cancer – A Canadian Sarcoma Research and Clinical Collaboration Study (CanSaRCC)
Authors: Dutra Marina Parisi , Rodrigues Caroline Mary , Peretz‐Soroka Hagit , Ribeiro Mauricio , Shultz David , Hodgson David , Tsang Derek S. , Gupta Abha A. 
Published: May 2023

AbstractBackgroundRadiation‐induced sarcoma (RIS) is a late toxicity of radiation therapy (RT) usually associated with poor prognosis. Due to ongoing improvements in childhood cancer treatment and patient outcomes, RIS may become more prevalent notwithstanding evolving indications for RT. Due to limited reported studies, we sought to review our experience with RIS in survivors of pediatric cancer.MethodologyData were collected on RIS patients following treatment for childhood cancer (initial diagnosis <18 years) identified in the CanSaRCC database. Additionally, details on the protocol guidance at time of treatment were compared with current guidelines for the same disease.ResultsAmong 12 RIS identified, median age at initial diagnosis was 3.5 years (range 0.16–14) and the latency from RT to RIS diagnosis was 24.5 (range 5.4–46.2) years. Initial diagnoses included neuroblastoma, rhabdomyosarcoma, Ewing sarcoma, Wilms tumor, retinoblastoma and Hodgkin's Lymphoma. RIS histologies included osteosarcoma and soft tissue sarcomas. In comparison to protocols followed at time of diagnosis to current ones (2022), 7/12 (58%) patients would have required RT. RIS treatment included chemotherapy, radiation and surgery in 3/11 (27%), 10/11 (90%), and 7/11 (63%) patients, respectively. With a median follow‐up time of 4.7 years from diagnosis of RIS, 8 (66%) patients were alive and 4 (33%) had died of progressive RIS.ConclusionRIS is a serious late effect of radiotherapy in childhood cancer; however, radiation remains an integral component of primary tumor management and requires participation from a specialized multi‐disciplinary team, aiming to mitigate RIS and other potential late effects.
A Comparative Study of the Structural and Optical Properties of ZnS Films Deposited by Spray‐Pyrolysis Technique
Authors: Najim Abdessamad , Hartiti Bouchaib , Nkuissi Hervé Joël Tchognia , Labrim Hicham , Fadili Salah , Ertugrul Mehmet , Thevenin Philippe , Budak Hasan Feyzi , Kasapoğlu Ahmet Emre 
Published: May 2023

AbstractThis study aims at synthesizing zinc sulfide (ZnS) thin films using spray pyrolysis method. The effect of the Zn concentration on the physical properties of ZnS is investigated using X‐ray diffraction (XRD), scanning electron microscope (SEM), UV–Vis spectrophotometer, photoluminescence (PL), and Raman spectroscopy. XRD shows a preferential orientation along the (111) direction corresponding to the ZnS cubic structure. Based on the XRD results, it is seen that low zinc concentrations compared to sulfur content can increase the crystalline quality of films. Raman spectra confirm the presence of the ZnS cubic structure observed by XRD and show the presence of sprayed ZnS vibrational modes for all films. PL emission spectrum of ZnS confirms the presence of Zn and S atoms at all molar concentrations. SEM reveals densely packed and uniformly distributed grains with precise shapes. The elemental analysis confirms the growth of stochiometric Zn/S ratio. The optical analysis shows a high transmittance around 88% in the visible range of the solar spectrum with optical band gaps varying from 3.4 to 3.6 eV. These properties are interesting and show that ZnS thin films can be used as buffer layers in thin film solar cells applications.
Carbonized Nickel‐Loaded Spent Coffee Grounds Modified BiOCl Photocatalysts for Enhanced Degradation of Ofloxacin
Authors: Long Anchun , Yu Yongchang , Ge Xianlong , Song Yankai , Meng Minfeng , Hu Shaohua , An Yarui , Gu Yingying 
Published: May 2023

AbstractWater pollution has posed a serious threat to the environment and human health. There is an urgent need to develop highly efficient and application‐convenient photocatalytic materials. To overcome this critical problem, the carbonized nickel‐loaded spent coffee grounds modified BiOCl (CNSCG‐BOC‐8) photocatalyst is prepared by using facile calcination and hydrolysis method. The optimum substrate carbonization temperature, the amount of substrate, and the loading amount of nickel ion are discussed. Further, the photocatalytic performance of the catalyst is tested using Ofloxacin (OFX) as target pollutant under ultraviolet and visible light (UV–vis light). The as‐obtained photocatalysts show the degradation efficiency of OFX in the prepared composite reaches 87% within 40 min under ultraviolet and visible light. Moreover, the results show that CNSCG‐BOC‐8 has better photoelectricity, excellent cycle stability, and is environment‐friendly. Therefore, this paper provides an important reference for the rational development and use of Ni‐loaded biomass‐derived carbon as the substrate to modify bismuth‐based photocatalyst for environmental remediation.
Ni−CeO2 Heterostructure Promotes Hydrogen Evolution Reaction via Tuning of the O−H Bond Length of Adsorbed Water at the Electrolyte/Electrode Interface
Authors: Yang Xiaoling , Xi Menghua , Guo Xing , Shen Jianhua , Liu Zhen , Jiang Hongliang , Zhu Yihua 
Published: May 2023

AbstractUnderstanding the properties and structure of reactant water molecules at the electrolyte solution/electrode interface is relevant to know the mechanisms of hydrogen evolution reaction (HER). However, this approach has rarely been implemented due to the elusive local microenvironment in the vicinity of the catalyst. Taking the Ni−CeO2 heterostructure immobilized onto carbon paper (Ni−CeO2/CP) as a model, the dynamic behavior of adsorbed intermediates during the reaction was measured by in situ surface‐enhanced infrared absorption spectroscopy with attenuated total reflection configuration (ATR‐SEIRAS). Theoretical calculations are used in combination to comprehend the potential causes of increased HER activity. The results show that the O−H bond of adsorbed water at the electrolyte solution/electrode interface becomes longer for promoting the dissociation of water and accelerating the kinetically slow Volmer step. In addition, forming the Ni−CeO2 heterostructure interface optimizes the hydrogen adsorption Gibbs free energy, thus increasing HER activity. Therefore, the Ni−CeO2/CP electrode exhibits remarkably low HER overpotentials of 37 and 119 mV at 10 and 100 mA cm−2, which are close to commercial Pt/C (16 and 102.6 mV, respectively).
Validation of multiparametric panels for bovine mesenchymal stromal cell phenotyping
Authors: Heyman Emma , Meeremans M. , Van Poucke M. , Peelman L. , Devriendt B. , De Schauwer Catharina 
Published: May 2023

AbstractBovine mesenchymal stromal cells (MSCs) display important features that render them valuable for cell therapy and tissue engineering strategies, such as self‐renewal, multi‐lineage differentiation, as well as immunomodulatory properties. These cells are also promising candidates to produce cultured meat. For all these applications, it is imperative to unequivocally identify this cell population. The isolation and in vitro tri‐lineage differentiation of bovine MSCs is already described, but data on their immunophenotypic characterization is not yet complete. The currently limited availability of monoclonal antibodies (mAbs) specific for bovine MSC markers strongly hampers this research. Following the minimal criteria defined for human MSCs, bovine MSCs should express CD73, CD90, and CD105 and lack expression of CD14 or CD11b, CD34, CD45, CD79α, or CD19, and MHC‐II. Additional surface proteins which have been reported to be expressed include CD29, CD44, and CD106. In this study, we aimed to immunophenotype bovine adipose tissue (AT)‐derived MSCs using multi‐color flow cytometry. To this end, 13 commercial Abs were screened for recognizing bovine epitopes using the appropriate positive controls. Using flow cytometry and immunofluorescence microscopy, cross‐reactivity was confirmed for CD34, CD73, CD79α, and CD90. Unfortunately, none of the evaluated CD105 and CD106 Abs cross‐reacted with bovine cells. Subsequently, AT‐derived bovine MSCs were characterized using multi‐color flow cytometry based on their expression of nine markers. Bovine MSCs clearly expressed CD29 and CD44, and lacked expression of CD14, CD45, CD73, CD79α, and MHCII, while a variable expression was observed for CD34 and CD90. In addition, the mRNA transcription level of different markers was analyzed using reverse transcription quantitative polymerase chain reaction. Using these panels, bovine MSCs can be properly immunophenotyped which allows a better characterization of this heterogenous cell population.