bluuebunny/crossref_metadata_2025_split huggingface dataset:
Margins in Stage I and II Oral Cavity Squamous Cell Carcinoma
Authors: Puram Sidharth V. , Mays Ashley C. , Bayon Rodrigo , Bell Diana , Chung Jeffson , Fundakowski Christopher E. , Johnson Bradley T. , Massa Sean T. , Sharma Arun , Varvares Mark A. 
Published: June 2023

ImportanceThe assessment and management of surgical margins in stage I and II oral cavity squamous cell carcinoma is one of the most important perioperative aspects of oncologic care, with profound implications for patient outcomes and adjuvant therapy. Understanding and critically reviewing the existing data surrounding margins in this context is necessary to rigorously care for this challenging group of patients and minimize patient morbidity and mortality.ObservationsThis review discusses the data related to the definitions related to surgical margins, methods for assessment, specimen vs tumor bed margin evaluation, and re-resection of positive margins. The observations presented emphasize notable controversy within the field about margin assessment, with early data coalescing around several key aspects of management, although studies are limited by their design.Conclusions and RelevanceStage I and II oral cavity cancer requires surgical resection with negative margins to obtain optimal oncologic outcomes, but controversy persists over margin assessment. Future studies with improved, well-controlled study designs are required to more definitively guide margin assessment and management.
The effect of extended shift work on autonomic function in occupational settings: A systematic review and meta-analysis
Authors: Jelmini Jacob D , Ross Jeremy , Whitehurst Lauren N , Heebner Nicholas R 
Published: June 2023

Abstract

Objective
To examine the effect of 24-h shift work on autonomic nervous system function via heart rate variability (HRV) methodologies.

Methods
Electronic databases (indexed in either PubMed, MEDLINE, CINAHL, SPORTDiscus, or OpenDissertations) were searched from January 1964 to March 2023. A modified Downs and Black checklist was used for assessing methodological quality and the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) approach was used to evaluate the quality of evidence. Study design, study population, study sample, shift work description, and assessment of HRV metrics and methods were extracted from each study.

Findings
A total of 58 478 study articles were identified, of which 12 articles met inclusion criteria. Sample sizes varied from eight to 60 participants, with the ratio of low- to high-frequency HRV (LF/HF) as the most common frequency-domain variable reported. Of the nine included studies that observed LF/HF, three (33.3%) demonstrated a significant increase after 24-h shift work. Moreover, of the five studies that reported HF, two (40%) noted a significant decrease after 24-h shift work. When observing risk of bias, two (16.6%) studies were low quality, five (41.7%) were moderate quality, and five (41.7%) were high quality.

Interpretation
There were inconsistent findings demonstrating an effect of 24-h shift work on autonomic function, with a suggested shift away from parasympathetic dominance. Discrepancies in HRV methodologies, such as the duration of recordings and hardware used for measurement, may have contributed to the disparity in findings. In addition, differences in roles and responsibilities across occupations may explain the incongruence in findings across studies.
Event‐triggered adaptive fuzzy optimal control of modular robot manipulators using zero‐sum differential game through value iteration
Authors: Dong Bo , Feng Zhian , Cui Yiming , Zhu Xinye , An Tianjiao 
Published: June 2023

SummaryIn this article, a novel event‐triggered zero‐sum differential game through value iteration (VI)‐based adaptive fuzzy control is proposed for modular robot manipulators (MRMs) with uncertain disturbance. The subsystem dynamic of MRMs is established by joint torque feedback (JTF) technology. An identifier based on fuzzy logic model (FLM) is established to identify unknown system dynamics. Then, the trajectory tracking control issue of MRMs with uncertain disturbance is transformed into a two‐player zero‐sum differential game. On the basis of event‐triggered mechanism and VI algorithm, the event‐triggered Hamilton–Jacobi–Issacs (HJI) equation is approximately solved through establishment of actor‐critic structure. Different from the traditional adaptive dynamic programming (ADP) algorithm, this scheme is based on adaptive fuzzy optimal control through an actor‐critic structure, which refers to adaptation of both optimal cost function and optimal control policy. Moreover, tracking errors of closed‐loop MRM system are demonstrated to be uniformly ultimately bounded (UUB) under Lyapunov stability theorem. At last, experimental examples and comparisons show the reliability and effectiveness of this method.
Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives
Authors: Zeng Qi , Huang Zhaoling 
Published: June 2023

AbstractThe desirable implantable neural interfaces can accurately record bioelectrical signals from neurons and regulate neural activities with high spatial/time resolution, facilitating the understanding of neuronal functions and dynamics. However, the electrochemical performance (impedance, charge storage/injection capacity) is limited with the miniaturization and integration of neural electrodes. The “crosstalk” caused by the uneven distribution of elctric field leads to lower electrical stimulation/recording efficiency. The mismatch between stiff electrodes and soft tissues exacerbates the inflammatory responses, thus weakening the transmission of signals. Though remarkable breakthroughs have been made through the incorporation of optimizing electrode design and functionalized nanomaterials, the chronic stability, and long‐term activity in vivo of the neural electrodes still need further development. In this review, the neural interface challenges mainly on electrochemistry and biology are discussed, followed by summarizing typical electrode optimization technologies and exploring recent advances in the application of nanomaterials, based on traditional metallic materials, emerging 2D materials, conducting polymer hydrogels, etc., for enhancing neural interfaces. The strategies for improving the durability including enhanced adhesion and minimized inflammatory response, are also summarized. The promising directions are finally presented to provide enlightenment for high‐performance neural interfaces in future, which will promote profound progress in neuroscience research.
Synergy of Organic and Inorganic Sites in 2D Perovskite for Fast Neutron and X‐Ray Imaging
Authors: Shao Wenyi , Li Qiang , He Tengyue , Zhang Yue , Niu Mengchen , Wang Hongyun , Zhang Zhenzhong , Zhou Yang , Wang Jian‐Xin , Fan Ruirui , Xia Xiaochuan , Bakr Osman M. , Mohammed Omar F. , Liang Hongwei 
Published: June 2023

AbstractFast neutron and X‐ray imaging are considered complementary nondestructive detection technologies. However, due to their opposite cross‐sections, development of a scintillator that is sensitive to both fast neutrons and X‐rays within a single‐material framework remains challenging. Herein, an organic–inorganic hybrid perovskite (C4H9NH3)2PbBr4 (BPB) is demonstrated as a scintillator that fully meets the requirements for both fast neutron and X‐ray detection. The hydrogen‐rich organic component acts as a fast neutron converter and produces detectable recoil protons. The heavy atom‐rich inorganic fraction efficiently deposits the energy of charged recoil protons and directly provides a large X‐ray cross‐section. Due to the synergy of these organic and inorganic components, the BPB scintillator exhibits high light yields (86% of the brightness of a commercial ZnS (Ag)/6LiF scintillator for fast neutrons; 22 000 photons per MeV for X‐rays) and fast response times (τdecay = 10.3 ns). More importantly, energy‐selective fast neutron and X‐ray imaging are also demonstrated, with high resolutions of ≈1 lp mm−1 for fast neutrons and 17.3 lp mm−1 for X‐rays; these are among the highest resolution levels for 2D perovskite scintillators. This study highlights the potential of 2D perovskite materials for use in combined fast neutron and X‐ray imaging applications.
Bandwidth Control and Symmetry Breaking in a Mott‐Hubbard Correlated Metal
Authors: Shoham Lishai , Baskin Maria , Tiwald Tom , Ankonina Guy , Han Myung‐Geun , Zakharova Anna , Caspi Shaked , Joseph Shay , Zhu Yimei , Inoue Isao H. , Piamonteze Cinthia , Rozenberg Marcelo J. , Kornblum Lior 
Published: June 2023

AbstractIn Mott materials strong electron correlation yields a spectrum of complex electronic structures. Recent synthesis advancements open realistic opportunities for harnessing Mott physics to design transformative devices. However, a major bottleneck in realizing such devices remains the lack of control over the electron correlation strength. This stems from the complexity of the electronic structure, which often veils the basic mechanisms underlying the correlation strength. This study presents control of the correlation strength by tuning the degree of orbital overlap using picometer‐scale lattice engineering. This study illustrates how bandwidth control and concurrent symmetry breaking can govern the electronic structure of a correlated SrVO3 model system. This study shows how tensile and compressive biaxial strain oppositely affect the SrVO3 in‐plane and out‐of‐plane orbital occupancy, resulting in the partial alleviation of the orbital degeneracy. The spectral weight redistribution under strain is derived and explained, which illustrates how high tensile strain drives the system toward a Mott insulating state. Implementation of such concepts can push correlated electron phenomena closer toward new solid‐state devices and circuits. These findings therefore pave the way for understanding and controlling electron correlation in a broad range of functional materials, driving this powerful resource for novel electronics closer toward practical realization.
A Novel Strategy for Visualizing, Tracing, and Measuring the Gastrointestinal Absorption of Silver Nanoparticles
Authors: Wang Xudong , Xu Lining , Ma Minghao , Xu Ming , Zhou Qunfang , Liu Sijin , Jiang Guibin 
Published: June 2023

AbstractThe silver‐based formulation has become one of the most widely used nanoagents for agrifood industry and clinical translation. However, the in vivo fate of silver nanoparticles (AgNPs) via oral exposure remains poorly understood. Here, a specific strategy is shown for tracking the gastrointestinal transformation, intestinal absorption, and organ distribution of particulate Ag after oral exposure by using the gold (Au)‐Ag core−shell NPs (Au@AgNPs). Taking advantage of both plasmonic and elemental characteristics of Au@AgNPs, the transformation of particulate Ag in the gastrointestinal tract (GIT), and later on, intestinal absorption are visualized at the single‐particle level. Furthermore, quantitative analysis reveals that the clearance rate of ingested particulate Ag from the blood and organs is much higher than that of ionic Ag, and at 6 h post‐oral administration, the former only contributed 0.08%, 1.10%, and 0.64% of the total Ag in the liver, spleen, and kidneys. Finally, the transcellular and paracellular pathways are identified as two possible mechanisms responsible for the transepithelial transport of particulate Ag. This study opens an avenue toward the examination of oral bioavailability of NPs and may have important implications in exploring the oral delivery technologies of nanoagents.
Observation of Chirality‐Induced Roton‐Like Dispersion in a 3D Micropolar Elastic Metamaterial
Authors: Chen Yi , Schneider Jonathan L. G. , Groß Michael F. , Wang Ke , Kalt Sebastian , Scott Philip , Kadic Muamer , Wegener Martin 
Published: June 2023

AbstractA theoretical paper based on chiral micropolar effective‐medium theory suggested the possibility of unusual roton‐like acoustical‐phonon dispersion relations in 3D elastic materials. Here, as a first novelty, the corresponding inverse problem is solved, that is, a specific 3D chiral elastic metamaterial structure is designed, the behavior of which follows this effective‐medium description. The metamaterial structure is based on a simple‐cubic lattice of cubes, each of which not only has three translational but also three rotational degrees of freedom. The additional rotational degrees of freedom are crucial within micropolar elasticity. The cubes and their degrees of freedom are coupled by a chiral network of slender rods. As a second novelty, this complex metamaterial is manufactured in polymer form by 3D laser printing and its behavior is characterized experimentally by phonon‐band‐structure measurements. The results of these measurements, microstructure finite‐element calculations, and solutions of micropolar effective‐medium theory are in good agreement. The roton‐like dispersion behavior of the lowest phonon branch results from two aspects. First, chirality splits the transverse acoustical branches as well as the transverse optical branches. Second, chirality leads to an ultrastrong coupling and hybridization of chiral acoustical and optical phonons at finite wavevectors.
MOF‐Based Electromagnetic Shields Multiscale Design: Nanoscale Chemistry, Microscale Assembly, and Macroscale Manufacturing
Authors: Panahi‐Sarmad Mahyar , Samsami Shakiba , Ghaffarkhah Ahmadreza , Hashemi Seyyed Alireza , Ghasemi Shayan , Amini Majed , Wuttke Stefan , Rojas Orlando , Tam Kam Chiu , Jiang Feng , Arjmand Mohammad , Ahmadijokani Farhad , Kamkar Milad 
Published: June 2023

AbstractThe effects of electromagnetic (EM) radiation have received increased attention, closely associated with the widespread use of electronics and wireless communication. A significant development in the area is the recent adoption of metal‐organic frameworks (MOFs) to effectively enable electromagnetic interference (EMI) shielding. MOF tunable molecular scaffold architecture offers numerous pathways to generate customizable magnetic and electrical properties, which are prerequisite materials characteristics for efficient EMI shielding performance. Their flexibility in terms of structural design, accompanied by high porosity and large specific surface area, makes MOFs excellent candidates to shield EM waves at multiple scales. Herein, the crucial role of molecular‐, nano‐, micro‐, and macro‐scale structural design is reviewed in accordance with the shielding performance of MOFs. The current design strategies of MOF‐based EMI shields are systematically outlined, and the shielding mechanisms are also expounded based on their structural features. The factors that hinder the widespread utilization of functional MOF‐derived EMI shields are also examined. Future research directions are unveiled for the rational design of the next‐generation MOF‐based EMI shields to address the pressing EM radiation concerns.
A Biomimicking and Multiarm Self‐Indicating Nanoassembly for Site‐Specific Photothermal‐Potentiated Thrombolysis Assessed in Microfluidic and In Vivo Models
Authors: Liu Kuan‐Ting , Quiñones Edgar Daniel , Liu Ming‐Hsin , Lin Che‐Wei , Chen Yan‐Ting , Chiang Chia‐Che , Wu Kevin Chia‐Wen , Fan Yu‐Jui , Chuang Er‐Yuan , Yu Jiashing 
Published: June 2023

AbstractThrombolytic and antithrombotic therapies are limited by short circulation time and the risk of off‐target hemorrhage. Integrating a thrombus‐homing strategy with photothermal therapy are proposed to address these limitations. Using glycol chitosan, polypyrrole, iron oxide and heparin, biomimicking GCPIH nanoparticles are developed for targeted thrombus delivery and thrombolysis. The nanoassembly achieves precise delivery of polypyrrole, exhibiting biocompatibility, selective accumulation at multiple thrombus sites, and enhanced thrombolysis through photothermal activation. To simulate targeted thrombolysis, a microfluidic model predicting thrombolysis dynamics in realistic pathological scenarios is designed. Human blood assessments validate the precise homing of GCPIH nanoparticles to activated thrombus microenvironments. Efficient near‐infrared phototherapeutic effects are demonstrated at thrombus lesions under physiological flow conditions ex vivo. The combined investigations provide compelling evidence supporting the potential of GCPIH nanoparticles for effective thrombus therapy. The microfluidic model also offers a platform for advanced thrombolytic nanomedicine development.
3D Printed Chondrogenic Functionalized PGS Bioactive Scaffold for Cartilage Regeneration
Authors: Wang Sinan , Luo Bin , Bai Baoshuai , Wang Qianyi , Chen Hongying , Tan Xiaoyan , Tang Zhengya , Shen Sisi , Zhou Hengxing , You Zhengwei , Zhou Guangdong , Lei Dong 
Published: June 2023

AbstractTissue engineering is emerging as a promising approach for cartilage regeneration and repair. Endowing scaffolds with cartilaginous bioactivity to obtain bionic microenvironment and regulating the matching of scaffold degradation and regeneration play a crucial role in cartilage regeneration. Poly(glycerol sebacate) (PGS) is a representative thermosetting bioelastomer known for its elasticity, biodegradability, and biocompatibility and is widely used in tissue engineering. However, the modification and drug loading of the PGS scaffold is still a key challenge due to its high temperature curing conditions and limited reactive groups, which seriously hinders its further functional application. Here, a simple versatile new strategy of super swelling‐absorption and cross‐linked networks locking is presented to successfully create the 3D printed PGS‐CS/Gel scaffold for the first time based on FDA‐approved PGS, gelatin (Gel) and chondroitin sulfate (CS). The PGS‐CS/Gel scaffold exhibits the desirable synergistic properties of well‐organized hierarchical structures, excellent elasticity, improved hydrophilicity, and cartilaginous bioactivity, which can promote the adhesion, proliferation, and migration of chondrocytes. Importantly, the rate of cartilage regeneration can be well‐matched with degradation of PGS‐CS/Gel scaffold, and achieve uniform and mature cartilage tissue without scaffold residual. The bioactive scaffold can successfully repair cartilage in a rabbit trochlear groove defect model indicating a promising prospect of clinical transformation.
Ion–Dipole Interaction Enabling Highly Efficient CsPbI3 Perovskite Indoor Photovoltaics
Authors: Wang Kai‐Li , Lu Haizhou , Li Meng , Chen Chun‐Hao , Bo Zhang Ding‐ , Chen Jing , Wu Jun‐Jie , Zhou Yu‐Hang , Wang Xue‐Qi , Su Zhen‐Huang , Shi Yi‐Ran , Tian Qi‐Sheng , Ni Yu‐Xiang , Gao Xing‐Yu , Zakeeruddin Shaik M. , Grätzel Michael , Wang Zhao‐Kui , Liao Liang‐Sheng 
Published: June 2023

AbstractMetal halide perovskites are ideal candidates for indoor photovoltaics (IPVs) because of their easy‐to‐adjust bandgaps, which can be designed to cover the spectrum of any artificial light source. However, the serious non‐radiative carrier recombination under low light illumination restrains the application of perovskite‐based IPVs (PIPVs). Herein, polar molecules of amino naphthalene sulfonates are employed to functionalize the TiO2 substrate, anchoring the CsPbI3 perovskite crystal grains with a strong ion–dipole interaction between the molecule‐level polar interlayer and the ionic perovskite film. The resulting high‐quality CsPbI3 films with the merit of defect‐immunity and large shunt resistance under low light conditions enable the corresponding PIPVs with an indoor power conversion efficiency of up to 41.2% (Pin: 334.11 µW cm−2, Pout: 137.66 µW cm−2) under illumination from a commonly used indoor light‐emitting diode light source (2956 K, 1062 lux). Furthermore, the device also achieves efficiencies of 29.45% (Pout: 9.80 µW cm−2) and 32.54% (Pout: 54.34 µW cm−2) at 106 (Pin: 33.84 µW cm−2) and 522 lux (Pin: 168.21 µW cm−2), respectively.
High‐Efficiency Silicon Nanowire Array Near Infrared Photodetectors via Length Control and SiOx Surface Passivation
Authors: Son Bongkwon , Shin Sang‐Ho , Zhao Zhi‐Jun , Ju Byeong‐Kwon , Jeong Jun‐Ho , Kim Munho , Tan Chuan Seng 
Published: June 2023

AbstractSilicon (Si) nanowire (NW) array is a promising light‐trapping platform due to the strong interaction between light and nanostructure. A photodetector benefits from the improved optical absorption in the Si NW array. Although the optical absorption increases with the NW length, the large NW length is not always preferable owing to the large surface area. Herein, the systematic study on the Si NW array photodetectors with varied NW lengths is investigated. It is revealed that the photodetectors with 1 µm length provide a highest responsivity of 0.65 A W−1 and a specific detectivity of 1.40 × 109 cm Hz1/2 W−1 at the wavelength of 1000 nm, including the dark current of 54 µA at 1 V. In addition, the silicon oxide (SiOx) surface passivation is introduced to induce the high photogain. As a result, the responsivity is improved by 13 times (0.55 A W−1) at 1100 nm. This work proposes high‐efficiency Si NW array photodetectors by the NW array length control and the SiOx surface passivation.
Graph Theory Design of 3D Printed Conductive Lattice Electrodes
Authors: Huddy Julia E. , Tiwari Anand P. , Zhao Huan , Li Yan , Scheideler William J. 
Published: June 2023

Abstract3D printing has the promising capability to fabricate engineered lattice structures with broadly tunable surface area and optimal geometries for maximizing structural and functional properties. This study characterizes the electrical conductivity of 3D lattices of varying size, structure, and porosity to guide additively manufactured electrode design in energy storage devices. Graph theory‐based calculations and experiments comparing the conductivity of multiple strut lattice structures and illustrating the scaling laws governing architectures with either coated or solid conductive struts are presented. The lightweight lattices explored here show higher conductivity than random foams that lack a periodic mesostructure. It is experimentally demonstrated that the 3D lattice type influences the specific capacity when employed in supercapacitors, outperforming 2D supercapacitor counterparts, and other 3D printed electrodes while allowing for optimization of the design for different energy storage applications. Additionally, it is shown that tuning the physical structure of the lattices allows for precise control over the electrical response to mechanical loading, as confirmed through experimental measurements. The lattice structure programs the electrodes’ mechanical stiffness, with higher relative density samples showing higher Young's modulus. These results can serve to guide the design of 3D printed electrodes in a variety of electrochemical and electromechanical device applications.