bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptation strategies and neurophysiological response in early-stage Parkinson's disease: BioVRSea approach
Authors: Jacob Deborah , Guerrini Lorena , Pescaglia Federica , Pierucci Simona , Gelormini Carmine , Minutolo Vincenzo , Fratini Antonio , Di Lorenzo Giorgio , Petersen Hannes , Gargiulo Paolo 
Published: July 2023

IntroductionThere is accumulating evidence that many pathological conditions affecting human balance are consequence of postural control (PC) failure or overstimulation such as in motion sickness. Our research shows the potential of using the response to a complex postural control task to assess patients with early-stage Parkinson's Disease (PD).MethodsWe developed a unique measurement model, where the PC task is triggered by a moving platform in a virtual reality environment while simultaneously recording EEG, EMG and CoP signals. This novel paradigm of assessment is called BioVRSea. We studied the interplay between biosignals and their differences in healthy subjects and with early-stage PD.ResultsDespite the limited number of subjects (29 healthy and nine PD) the results of our work show significant differences in several biosignals features, demonstrating that the combined output of posturography, muscle activation and cortical response is capable of distinguishing healthy from pathological.DiscussionThe differences measured following the end of the platform movement are remarkable, as the induced sway is different between the two groups and triggers statistically relevant cortical activities in α and θ bands. This is a first important step to develop a multi-metric signature able to quantify PC and distinguish healthy from pathological response.
Associations of chest X-ray trajectories, smoking, and the risk of lung cancer in two population-based cohort studies
Authors: Liu Ya , Feng Zhuowei , Fan Zeyu , Zhang Yu , Li Chenyang , Liu Xiaomin , Duan Hongyuan , Cui Xiaonan , Zhang Liwen , Sheng Chao , Yang Lei , Gao Ying , Wang Xing , Zhang Qing , Lyu Zhangyan , Song Fangfang , Huang Yubei , Song Fengju 
Published: July 2023

ObjectivesDespite the increasing use of computed tomography (CT), chest X-ray (CXR) remains the first-line investigation for suspected lung cancer (LC) in primary care. However, the associations of CXR trajectories, smoking and LC risk remain unknown.MethodsA total of 52,486 participants from the PLCO and 22,194 participants from the NLST were included. The associations of CXR trajectories with LC risk were evaluated with multivariable COX regression models and pooled with meta-analyses. Further analyses were conducted to explore the stratified associations by smoking status and the factors associated with progression and regression in CXR.ResultsCompared to stable negative CXR (CXRSN), HRs (95%CIs) of LC incidence were 2.88(1.50–5.52), 3.86(2.03–7.35), and 1.08(0.80–1.46) for gain of positive CXR (CXRGP), stable positive CXR (CXRSP), and loss of positive CXR (CXRLP), while the risk of LC mortality were 1.58(1.33–1.87), 2.56(1.53–4.29), and 1.05(0.89–1.25). Similar trends were observed across different smoking status. However, LC risk with CXRGP overweighed that with CXRSP among ever smokers [2.95(2.25–3.88) vs. 2.59(1.33–5.02)] and current smokers [2.33(1.70–3.18) vs. 2.26(1.06–4.83)]. Moreover, compared to CXRSN among never smokers, even no progression in CXR, the HRs(95%CIs) of LC incidence were 7.39(5.60–9.75) and 31.45(23.58–41.95) for ever and current smokers, while risks of LC mortality were 6.30(5.07–7.81) and 27.17(21.65–34.11). If participants gained positive CXR, LC incidence risk significantly climbed to 22.04(15.37–31.60) and 71.97(48.82–106.09) for ever and current smokers, while LC mortality risk climbed to 11.90(8.58–16.50) and 38.92(27.04–56.02). CXRLP was associated with decreased LC risk. However, even smokers lost their positive CXR, and the increased risks of LC incidence and mortality did not decrease to non-significant level. Additionally, smoking was significantly associated with increased risk of CXRGP but not CXRLP.ConclusionLC risk differed across CXR trajectories and would be modified by smoking status. Comprehensive intervention incorporating CXR trajectories and smoking status should be recommended to reduce LC risk.
Real-world study of PD-1/L1 immune checkpoint inhibitors for advanced non-small cell lung cancer after resistance to EGFR-TKIs
Authors: Wei Kunchen , Zhou Chao , Chen Yang , Feng Xiao , Tang Hao 
Published: July 2023

BackgroundProgrammed cell death-1 (PD-1) and its ligand 1 (PD-L1) inhibitors have achieved good efficacy and safety in patients with advanced EGFR mutation-negative non-small cell lung cancer (NSCLC), but their efficacy in patients with previous EGFR mutations is limited. The aim of the present study was to explore the efficacy of PD-1/L1 immune checkpoint inhibitors for the treatment of patients with advanced NSCLC who are resistant to EGFR-TKIsMethodsThis retrospective study included 123 patients with stage IV NSCLC who received treatment in Shanghai Changzheng Hospital between January 2019 and January 2022 after failure of first-line EGFR-TKIs. Of them, 39 received ICIs + chemotherapy and anti-angiogenic drugs (ICIs+BCP group), 51 received ICIs monotherapy (ICIs group), and 33 received chemotherapy and anti-angiogenic drugs (BCP group). The gender, age, smoking history, ECOG score, EGFR mutation type, PD-L1 TPS expression, and the first routine blood index before second-line treatment of all enrolled patients were recorded, and their clinical outcomes and prognosis factors were analyzed.ResultsThere was no significant difference in the objective response rate (ORR) and disease control rate (DCR) between the three groups. Patients in ICIs+BCP group had better prognosis than those in ICIs monotherapy group (PFS:9.5 vs. 4.64 months, p&lt;0.001; OS: 16.97 vs. 7.9 months p&lt;0.001) or BCP group (9.5 vs. 6.48 months, p&lt;0.005; OS: 16.97 vs. 11.39 months p&lt;0.005).ConclusionOur findings suggest that in the real-world practice in China, PD-1/L1 immune checkpoint inhibitors combined with chemotherapy and anti-angiogenic drugs are effective for the treatment of patients with advanced NSCLC who are resistant to EGFR-TKIs.
“Let me tell you what I think about online psychological help.” A thematic analysis of voluntary opinions collected at the onset of the COVID-19 pandemic
Authors: Wesołowski Arkadiusz , Skawińska Julianna , Soroko Emilia 
Published: July 2023

IntroductionThe COVID-19 pandemic shifted many aspects of life from face-to-face to an online form, including psychological help. Many people had to face the choice of adjourning contact with a psychologist or shifting it to the Internet. This study aimed to develop an understanding of attitudes and opinions toward relatively new phenomenon in Poland – online psychological help.MethodSeventy two (N=72) statements about relationship between COVID-19 pandemic and online psychological help from (potential) patients were included in this research. The statements were collected from a community sample via open-ended question for volunteers added to an online survey conducted regarding an existing project. The statements were exclusively written responses to the following question: If you want to provide us with something about the relationships between the COVID-19 pandemic and online help/psychotherapy, please let us know below. By reason of exploratory character of our study and general phenomenological philosophical approach and constructionist approach, a thematic analysis method was used to analyze the data.ResultsThe analysis led us to identify three general themes with sub-themes that refer to meaningful aspects of online psychological help: 1. Online psychological help situates in the shadow of face-to-face help, 1.1. It frustrates the needs, especially the need for psychological contact, 1.2. It contributes to negative emotions, 1.3. It is sometimes better than the face-to-face help; 2. Online psychological help is a solution during the COVID-19 pandemic, 2.1. It provides a sense of continuity during lockdown, 2.2. It is a means to adapt to exceptional circumstances, 3. The concerns about the credibility and effectiveness of online psychological help.DiscussionThe results show (potential) patients’ attitudes (including emotions, thoughts, and concerns) toward online psychological help. The perspective presented here could be beneficial to professionals. A better understanding of client/patient attitudes will allow for more accurate customization of the online help and sensitize psychologists to the emotions that may occur about online psychological help. It could also be beneficial for patients to understand how other people would feel about online psychological help and develop ones’ own self-awareness of the attitudes toward online psychological help.
Emotional regulation and body dissatisfaction: the mediating role of anger in young adult women
Authors: Momeñe Janire , Estévez Ana , Herrero Marta , Griffiths Mark D. , Olave Leticia , Iruarrizaga Itziar 
Published: July 2023

IntroductionEmotion regulation difficulties have an important role in the presence of negative self-image. These problems in the self-regulation of emotion could lead to negative emotional processes (such as anger) that can lead to body dissatisfaction. Therefore, the aim of the present study was to examine emotion regulation difficulties than can negatively impact self-image and to understand if anger acts as mediator in the relationship between emotion regulation and body dissatisfaction.MethodsA cross-sectional study was carried out comprising 565 young adult women aged 18–30 years. The participants were administered the Difficulties in Emotion Regulation Scale (DERS), the State-Trait Anger Expression Inventory 2 (STAXI-2), and the Body Dissatisfaction dimension of the Eating Disorder Inventory-2 (EDI-2). The proposed hypotheses were tested by path analysis in MPlus 8.0.ResultsThe results indicated that anger had a positive significant effect on body dissatisfaction as well as the non-acceptance of emotional responses, the lack of emotional awareness, and the lack of emotional clarity. Of all the dimensions of emotional regulation difficulties, impulse control difficulty was the dimension which had a positive significant indirect effect on body dissatisfaction explained by increased anger.DiscussionThe present study suggests the importance of emotion regulation in the prevention of body dissatisfaction. Impulse control difficulty may be the key emotion regulation emotion in explaining the increments of anger that lead to body dissatisfaction. Among young adults, the promotion of positive body image can be promoted by helping this population to self-regulate their anger impulses.
A novel COVID-19 program, delivering vaccines throughout rural and remote Australia
Authors: Gardiner Fergus W. , Schofield Zoe , Hendry Miranda , Jones Kate , Smallacombe Mandy , Steere Mardi , Beach Jenny , MacIsaac MaryBeth , Greenberg Randall , Crawford Candice , Trivett Melanie , Morris Judah , Spring Breeanna , Quinlan Frank , Churilov Leonid , Rallah-Baker Kris , Gardiner Elli , O’Donnell John 
Published: July 2023

BackgroundThe Royal Flying Doctor Service of Australia (RFDS) established a unique SARS-CoV-2 vaccination program for vaccinating Australians that live in rural and remote areas. This paper describes the preparation and response phases of the RFDS response.MethodsThis study includes vaccinations conducted by the RFDS from 01 January 2021 until 31 December 2021 when vaccines were mandatory for work and social activities. Prior to each clinic, we conducted community consultation to determine site requirements, patient characteristics, expected vaccination numbers, and community transmission rates.FindingsNinety-five organizations requested support. The majority (n = 60; 63.2%) came from Aboriginal Community Controlled Health Organizations. Following consultation, 360 communities were approved for support. Actual vaccinations exceeded expectations (n = 70,827 vs. 49,407), with a concordance correlation coefficient of 0.88 (95% CI, 0.83, 0.93). Areas that reported healthcare workforce shortages during the preparation phase had the highest population proportion difference between expected and actual vaccinations. Areas that reported high vaccine hesitancy during the preparation phase had fewer than expected vaccines. There was a noticeable increase in vaccination rates in line with community outbreaks and positive polymerase chain reaction cases [r (41) = 0.35, p = 0.021]. Engagement with community leaders prior to clinic deployment was essential to provide a tailored response based on community expectations.
Sea Surface Temperature Changes Reflected by Diatoms in the P6-10 Core from 1893 to 2013 from Prydz Bay, Antarctica
Authors: Huang Yue , Ma Ruiwen , Li Jie , Tu Shuyu 
Published: July 2023

Identification and analysis was conducted on the diatoms from the 19 cm sediment of the P6-10 core, drilled from China’s 29th Antarctic Expedition, to attempt to semi-quantitatively reconstruct the annual sea surface temperature (SST) of Prydz Bay from 1893 to 2013. There were 30 species within the 12 genera of diatoms found, and the main contributors were Fragilariopsis curta, F. cylindrus, F. sublinearis, F. ritscheri, and Thalassiosira antarctica. They were divided into three categories based on their ecological affinity. The percentages of four specific species, i.e., F. curta, F. cylindrus, F. ritscheri, and F. separanda, which might be low SST indicators, were added together to represent the SST of Prydz Bay. With the help of cluster analysis, diatom assemblages were divided into diatom zones. Therefore, SST changes were divided into five stages by both the percentage of those four diatom species and the diatom zones: the high-temperature stage from 1893 to 1903, the cooling stage from 1903 to 1936, the stable and warm stage from 1936 to 1983, the low-temperature stage from 1983 to 1996, and the temperature rising stage from 1996 to 2013. On the multidecadal scale, SST change was affected by adjustments to solar radiation. On the contrary, the ENSO events mainly affected SST on the interannual scale. In addition, regarding the unique geographical environment (such as regional atmospheric circulation and a wind field) in Prydz Bay, volcanic eruptions and the like also played important roles in some exceptional periods.
PENGARUH PEER GRUP EDUCATION TERHADAP TINGKAT PENGETAHUAN LANSIA TENTANG KETASIDOSIS DIABETIKUM DI POSBINDU LANSIA SAKURA KELURAHAN PLESUNGAN KABUPATEN KARANGANYAR
Authors: Windyastuti Erlina , Mardiyah Siti 
Published: July 2023

Diabetes Mellitus (DM) merupakan salah satu penyakit dengan pengobatan jangka Panjang dan seumur hidup. DM merupakan salah satu penyakit sistemik yang mampu memunculkan komplikasi. Salah satu komplikasi yang muncul apda penderita DM adalah Ketoasidosisi Diabetik. Ketoasidosis diabetik (KAD) merupakan komplikasi akut diabetes melitus tipe 1 yang ditandai dengan dehidrasi, kehilangan elektrolit, asidosis dan disebabkan oleh pembentukan keton yang berlebihan. Keadaan ini merupakan gangguan metabolisme yang paling serius dan mengancam jiwa. Tujuan penelitian ini adalah menganalisis pengaruh pendidikan kesehatan peer gorup education terhadap tingkat pengetahuan Ketoasidosis Diabetikum pada lansia DM di Posbindu Lansia Sakura di wilayah Kerja Puskesmas Gondangrejo. Responden lansia berjumlah 25 orang. Uji statistic dengan menggunakan Wilcoxon diperoleh nilai p value = 0,01. Nilai p value = 0,01 lebih kecil dari alpha 0,05 berarti ada pengaruh pendidikan kesehatan peer gorup education terhadap tingkat pengetahuan Ketoasidosis Diabetikum pada penderita DM di Posbindu Lansia Sakura di wilayah Kerja Puskesmas Gondangrejo. Hasil penelitian ini dapat menambah menambah informasi bagi perawat dalam penatalaksanaan peningkatan pengetahuan Ketoasidosis Diabetikum melalui pendidikan kesehatan peer gorup education.
Diabetes Mellitus (DM) is a disease with long-term and lifelong treatment. DM is a systemic disease that can cause complications. One of the complications that arise in DM patients is diabetic ketoacidosis. Diabetic ketoacidosis (DKA) is an acute complication of type 1 diabetes mellitus which is characterized by dehydration, loss of electrolytes, acidosis and is caused by excessive formation of ketones. This condition is the most serious and life-threatening metabolic disorder. The purpose of this study was to analyze the effect of peer group health education on the level of knowledge of diabetic ketoacidosis in elderly DM at the Elderly Sakura Posbindu in the working area of the Gondangrejo Health Center. Elderly respondents totaled 25 people. Statistical test using Wilcoxon obtained p value = 0.01. The p value = 0.01 is smaller than alpha 0.05, meaning that there is an influence of peer group education health education on the level of knowledge of diabetic ketoacidosis in DM sufferers at the Elderly Sakura Posbindu in the working area of the Gondangrejo Health Center. The results of this study can add additional information for nurses in the management of increased knowledge of diabetic ketoacidosis through peer group education health education.
PENGARUH PENDIDIKAN MENGGUNAKAN VIDEO GAME DEDIMIA TERHADAP UPAYA PENCEGAHAN KEPUTIHAN PADA KEHAMILAN DI BALAI KESEHATAN GAMBIRSARI SURAKARTA
Authors: Rohmatika Dheny , Apriani Arista , Ernawati E 
Published: July 2023

Anemia kehamilan adalah keadaan ibu dengan kadar hemoglobin di bawah 11 g% pada trimester pertama dan ketiga, atau kadar hemoglobin di bawah 10,5 g% pada trimester berikutnya, menyebabkan ruam, berat lahir rendah, pengangkatan janin, kondisi medis ibu seperti kemampuan keselamatan yang terhambat, batas kerja yang berkurang, dan peningkatan risiko penyakit jantung. Salah satu cara untuk mencegah terjadinya anemia pada masa kehamilan adalah dengan memberikan informasi melalui media yang efektif. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pendidikan menggunakan video game DEDIMIA (Lokasi awal kelemahan) terhadap upaya pencegahan keputihan pada kehamilan di Balai Kesehatan Gambirsari Surakarta. Pemeriksaan ini merupakan eksplorasi kuantitatif dengan rencana penelitian percobaan dengan rencana pra-eksplorasi, prosedur pengujiannya adalah pemeriksaan lengkap. Jumlah sampel penelitian ini adalah 30 responden. Instrumen penelitian menggunakan kuesioner pengetahuan dan Analisa data menggunakan uji Wilcoxon. Berdasarkan analisis uji Wilcoxon dapat ditarik kesimpulan bahwa terdapat perbedaan antara tingkat pengetahuan sebelum dan sesudah perlakuan (p-Value 0,000). Oleh karena itu dapat diduga bahwa sebenarnya diterima adanya pengaruh pemberian rekaman EDEMIA pada ibu hamil dalam upaya mencegah keputihan pada kehamilan.
Weakness of pregnancy is a state of a mother with a hemoglobin level under 11 g% in the first and third trimesters, or a hemoglobin level under 10.5 g% in the subsequent trimester, causing rashness, low birth weight, fetus removal, maternal medical conditions like hindered safe capability, diminished work limit, and expanded chance of coronary illness. One way to prevent the effects of anemia during pregnancy is to provide information through effective media. The point of the review was to decide the impact of schooling utilizing video activity DEDIMIA (early location of frailty) on endeavors to forestall paleness in pregnancy at the Gambirsari Wellbeing Center in Surakarta. This examination is a quantitative exploration with trial research plan with pre-exploratory plans, the testing procedure is complete inspecting. The example in this study were 30 respondents. Instrument of research used quessionare of knowledge and data analysed used Wilcoxon test. Based on the Wilcoxon test analysis, it is possible to draw the conclusion that there is a difference between the level of knowledge before and after treatment (p-Value 0.000). Accordingly it tends to be presumed that genuinely it is accepted that there is an impact of giving EDEMIA recordings to pregnant ladies on endeavors to forestall paleness in pregnancy.
UPAYA PENURUNAN TINGKAT DISTRESS ANAK TODDLER SAAT PEMASANGAN INFUS DENGAN MENGGUNAKAN KOMBINASI TERAPI MUSIK DAN PARENTAL HOLDING
Authors: Dwi Lestari Puji Utami Ratih , Ulfa Alfiatun Nuriyah Nela 
Published: July 2023

Hospitalisasi merupakan pengalaman yang tidak menyenangkan bagi anak dan menimbulkan stress pada anak. Tindakan pemasangan infus menyakitkan bagi anak dan menimbulkan distress. Salah satu tindakan untuk mengurangi distress anak dengan menerapkan kombinasi terapi musik dan parental holding. Penelitian ini bertujuan untuk mengetahui tingkat stress anak pada saat pemasangan infus setelah diberikan kombinasi terapi musik dan parental holding dengan desain penelitian Post Test Only Control Group Design. Hasil uji Mann Whitney pada 38 sampel menunjukkan p value = 0,027, dimana kelompok kombinasi terapi musik dan parental holding mampu menurunkan tingkat distress dengan rata-rata penurunan 15,53 sedangkan kelompok parental holding hanya mampu menurunkan tingkat distress dengan rata-rata 23,47. Disimpulkan bahwa kombinasi terapi musik dan parental holding lebih efektif dalam proses penurunan tingkat distress anak usia toodler selama prosedur pemasangan infus.

Hospitalization is an unpleasant experience for children and causes stress in children. The act of inserting an infusion is painful for the child and causes distress. One of the measures to reduce children's distress is by implementing a combination of music therapy and parental holding. This study aims to determine the stress level of children at the time of infusion after being given a combination of music therapy and parental holding with the Post Test Only Control Group Design research design. The results of the Mann Whitney test on 38 samples showed a p value = 0.027, where the combination of group of music therapy and parental holding was able to reduce the level of distress with an average decrease of 15.53, while the parental holding group was only able to reduce the level of distress with an average of 23.47. It was concluded that the combination of music therapy and parental holding was more effective in reducing the distress level of toddlers during infusion procedures.
Soil macrofauna correlations with soil chemical and physical properties and crop sequences under no-tillage
Authors: Batista Itaynara , Machado Deivid Lopes , Correia Maria Elizabeth Fernandes , Spinelli Maria Helena Moraes , Corá José Eduardo 
Published: July 2023

ABSTRACTSoil macrofauna is an important indicator of soil quality, as it is sensitive to changes in the environment as a result of soil management, which includes soil chemical and physical properties and the diversity of cultivated species. This study aimed to evaluate the composition and structure of soil macrofauna under a no-tillage system in different crop sequences, with and without crop rotation, over two growing seasons: a rainy summer and a dry winter. The crop sequences were soybean/corn rotation in the summer and corn in the winter; soybean/corn rotation in the summer and sunn hemp in the winter; soybean monoculture in the summer and sunn hemp in the winter; and corn monoculture in the summer and corn monoculture in the winter growing season. The nutrient content of the crop residues left on the soil surface, soil chemical and physical properties, and soil macrofauna were determined. Functional plant groups (grasses or legumes) individually influenced the composition of soil macrofauna more significantly than the effect of crop sequence, with or without rotation, and growing season. Grasses favored an increased density of groups such as Oligochaeta, Isoptera, and Formicidae. In contrast, legumes contributed to the variation in the total density of individuals and Diplura and Coleoptera groups. Furthermore, the influence of functional plant groups (grasses or legumes) on the composition and density of soil macrofauna were related to soil chemical (P and N content) and physical properties (particulate organic carbon and soil moisture), which determined the composition of soil macrofauna groups.