bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the prevalence of antibiotic resistance patterns and drivers of antibiotics resistance of Salmonella in livestock and poultry-derived foods: a systematic review and meta-analysis in Bangladesh from 2000 to 2022
Authors: Ripon Rezaul Karim , Motahara Umma , Ahmed Ayesha , Devnath Nishrita , Mahua Fatema Akter , Hashem Rubaiya Binthe , Ishadi Kifayat Sadmam , Alam Adiba , Sujan Md Safaet Hossain , Sarker Md Samun 
Published: May 2023

Abstract

Background
Antimicrobial resistance (AMR) is a severe public health problem that Bangladeshis are dealing with nowadays. However, we wanted to investigate the pooled prevalence of Salmonella and AMR in Salmonella strains isolated from livestock- and poultry-derived foods between 1 January 2000 and 31 August 2022.

Methods
The metafor and metareg packages in the R programming language were used to conduct all analyses. We used a random-effect or fixed-effect model for pooled prevalence of Salmonella and AMR to Salmonella, depending on the heterogeneity test for each antibiotic. The heterogeneity was examined using stratified analyses, the meta-regression approach and sensitivity analysis.

Results
The combined prevalence of Salmonella in livestock and poultry-derived food in Bangladesh is 37%, according to the 12-research considered (95% CI: 23%–52%). According to subgroup analysis, neomycin had the lowest prevalence of resistance (4%, 95% CI: 1%–13%), whereas tetracycline had the highest prevalence of resistance (81%, 95% CI: 53%–98%). According to univariate meta-analysis and correlation analysis, the prevalence of Salmonella increased with the study period (β = 0.0179; 95% CI: 0.0059–0.0298, P = 0.0034; R2 = 46.11%) and without this, none of aforementioned variables was significantly associated with the detected heterogeneity and there was a positive relationship (r = 0.692, P = 0.001) between the Salmonella prevalence and study period.

Conclusions
AMR is rising alarmingly in Bangladesh by livestock-derived food consumption. However, monitoring and evaluating antibiotic sensitivity trends and developing effective antibiotic regimens may improve Salmonella infection inhibition and control in Bangladesh. Policymakers should be concerned about food handling practices. Doctors should be concerned when using prescribing antibiotics.
Transient receptor potential vanilloid 4 (TRPV4) in neutrophils enhances myocardial ischemia/reperfusion injury
Authors: Wu Yuwei , Lu Kai , Lu Yang , Liao Jie , Zhang Shaoshao , Yang Shuaitao , Zhao Ning , Dong Qian , Chen Lei , Wu Qiongfeng , Du Yimei 
Published: May 2023

Abstract
The Ca2+-permeable TRPV4 cation channel is expressed in neutrophils and contributes to myocardial ischemia/reperfusion injury. Here we tested the hypotheses that TRPV4 promotes neutrophil activation and subsequently aggregates myocardial ischemia/reperfusion injury. TRPV4 protein was confirmed in neutrophils, and its function was assessed by the current and intracellular Ca2+ concentration elevations evoked by TRPV4 agonists. Furthermore, TRPV4 agonists dose-dependently promoted migration toward fMLP, reactive oxygen species production, and myeloperoxidase release, which were prevented by pretreatment with a selective TRPV4 antagonist, in neutrophils from TRPV4 knockout mice, Ca2+-free medium, or BAPTA-AM + Ca2+-free medium. Blockade of TRPV4 also inhibited the effects of commonly used neutrophil activators fMLP and PMA. Mechanically, TRPV4 regulated neutrophil activation, particularly reactive oxygen species production, by affecting PKCα, P38, and AKT via Ca2+ signaling. In addition, isolated hearts infused with neutrophils from wild-type mice showed additional myocardial ischemia/reperfusion injuries but not those infused with TRPV4 knockout. Our study reveals that TRPV4-mediated neutrophil activation enhances myocardial ischemia/reperfusion injury, and it might be a novel therapeutic target for myocardial ischemia/reperfusion injury and other neutrophil-mediated inflammatory diseases.
Extracellular matrix remodelling in obesity and metabolic disorders
Authors: Musale Vishal , Wasserman David H , Kang Li 
Published: May 2023

AbstractObesity causes extracellular matrix (ECM) remodelling which can develop into serious pathology and fibrosis, having metabolic effects in insulin-sensitive tissues. The ECM components may be increased in response to overnutrition. This review will focus on specific obesity-associated molecular and pathophysiological mechanisms of ECM remodelling and the impact of specific interactions on tissue metabolism. In obesity, a complex network of signalling molecules such as cytokines and growth factors has been implicated in fibrosis. Increased ECM deposition contributes to the pathogenesis of insulin resistance at least in part through the activation of cell surface integrin receptors and CD44 signalling cascades. These cell surface receptors transmit signals to the cell adhesome which orchestrates an intracellular response that adapts to the extracellular environment. Matrix proteins, glycoproteins, and polysaccharides interact through ligand-specific cell surface receptors that interact with the cytosolic adhesion proteins to elicit specific actions. Cell adhesion proteins may have catalytic activity or serve as scaffolds. The vast number of cell surface receptors and the complexity of the cell adhesome have made study of their roles challenging in health and disease. Further complicating the role of ECM-cell receptor interactions is the variation between cell types. This review will focus on recent insights gained from studies of two highly conserved, ubiquitous axes and how they contribute to insulin resistance and metabolic dysfunction in obesity. These are the collagen-integrin receptor-IPP (ILK-PINCH-Parvin) axis and the hyaluronan-CD44 interaction. We speculate that targeting ECM components or their receptor-mediated cell signalling may provide novel insights into the treatment of obesity-associated cardiometabolic complications.
Kettle logic in abstract argumentation
Authors: Kampik Timotheus 
Published: May 2023

Abstract
Kettle logic is a colloquial term that describes an agent’s advancement of inconsistent arguments in order to defeat a particular claim. Intuitively, a consistent subset of the advanced arguments should exist that is at least as successful at refuting the claim as the advancement of the set of inconsistent arguments. In this paper, we formalize this intuition and provide a formal analysis of kettle logic in abstract argumentation, a fundamental approach to computational argumentation, showing that all of the analysed abstract argumentation semantics (inference functions)—with the exception of naive semantics, which is considered a mere simplistic helper for the construction of other semantics—suffer from kettle logic. We also provide an approach to mitigating kettle logic under some circumstances. The key findings presented in this paper highlight that agents that apply the inference functions of abstract argumentation, are—similarly to humans—receptive to persuasion by agents who deliberately advance inconsistent and intuitively ‘illogical’ claims. As abstract argumentation can be considered one of the most basic models of computational argumentation, this raises the question to what extent and under what circumstances kettle logic-free argumentation can and should be enforced by computational means.
Origin of neutron-capture elements with the Gaia-ESO survey: the evolution of s- and r-process elements across the Milky Way
Authors: Molero Marta , Magrini Laura , Matteucci Francesca , Romano Donatella , Palla Marco , Cescutti Gabriele , Vázquez Carlos Viscasillas , Spitoni Emanuele 
Published: May 2023

ABSTRACT
We investigate the origin of neutron-capture elements by analysing their abundance patterns and radial gradients in the Galactic thin disc. We adopt a detailed two-infall chemical evolution model for the Milky Way, including state-of-the-art nucleosynthesis prescriptions for neutron-capture elements. We consider r-process nucleosynthesis from merging neutron stars (MNS) and magneto-rotational supernovae (MR-SNe), and s-process synthesis from low- and intermediate-mass stars (LIMS) and rotating massive stars. The predictions of our model are compared with data from the sixth data release of the Gaia-ESO survey, from which we consider 62 open clusters with age ≳ 0.1 Gyr and ∼1300 Milky Way disc field stars. We conclude that: (i) the [Eu/Fe] versus [Fe/H] diagram is reproduced by both prompt and delayed sources, with the prompt source dominating Eu production; (ii) rotation in massive stars significantly contributes to the first peak s-process elements, but MNS and MR-SNe are necessary to match the observations; and (iii) our model slightly underpredicts Mo and Nd, while accurately reproducing the [Pr/Fe] versus [Fe/H] trend. Regarding the radial gradients, we find that: (i) our predicted [Fe/H] gradient slope agrees with observations from Gaia-ESO and other high-resolution spectroscopic surveys; (ii) the predicted [Eu/H] radial gradient slope is steeper than the observed one, regardless of how quick the production of Eu is, prompting discussion on different Galaxy-formation scenarios and stellar radial migration effects; and (iii) elements in the second s-process peak as well as Nd and Pr exhibit a plateau at low-Galactocentric distances, likely due to enhanced enrichment from LIMS in the inner regions.
Meteor cluster event indication in variable-length astronomical video sequences
Authors: Bednář Jan , Krauz Lukáš , Páta Petr , Koten Pavel 
Published: May 2023

ABSTRACT
In recent years, the study of parallel or cluster meteor events has become increasingly popular. Many imaging systems currently focus on meteor detection, but the algorithms exploiting the data from such systems do not investigate the probability of cluster or parallel meteor events. This paper presents a novel approach to indicate a potential meteor cluster or parallel meteor event based on variable-length astronomical video sequences. The presented algorithm consists of two main parts: meteor event pre-detection and meteor cluster event probability evaluation. The first part of the algorithm involves a meteor pre-detection method based on the Hough transform and the exact event location within the time domain. In addition to pre-detecting meteor events, the method outputs event trajectory parameters that are further exploited in a second part of the algorithm. This subsequent part of the algorithm then operates over these meteor trajectory parameters and indicates the probability of cluster occurrence. The algorithm is experimentally evaluated on video sequences generated by the Meteor Automatic Imager and Analyzer (MAIA) astronomical imaging system, covering the Draconid and September ϵ Perseid meteor showers. Compared to the current MAIA meteor detection software, the proposed part of the pre-detection algorithm shows promising results, especially the increased rate of correct meteor detection. The meteor cluster evaluation part of the algorithm then demonstrates its ability to successfully select related meteor event candidates (disintegrated from the same parental object) and reject unrelated ones.
Phenomenological power spectrum models for H α emission line galaxies from the Nancy Grace Roman Space Telescope
Authors: McCarthy Kevin S , Zhai Zhongxu , Wang Yun 
Published: May 2023

ABSTRACT
The High Latitude Spectroscopic Survey (HLSS) is the reference baseline spectroscopic survey for NASA’s Nancy Grace Roman Space Telescope, measuring redshifts of ∼10M H α emission line galaxies over a 2000 deg2 footprint at z = 1–2. In this work, we use a realistic Roman galaxy mock catalogue to explore optimal phenomenological modelling of the measured power spectrum. We consider two methods for modelling the redshift-space distortions (Kaiser squashing and another with a window function on β that selects out the coherent radial infall pairwise velocities, $\mathcal {M}_A$ and $\mathcal {M}_B$, respectively), two models for the non-linear impact of baryons that smear the baryon acoustic oscillation signal (a fixed ratio between the smearing scales in the perpendicular and parallel dimensions and another where these smearing scales are kept as free parameters, Pdw(k|k*) and Pdw(k|Σ⊥, Σ∥), respectively), and two analytical emulations of non-linear growth (one employing the halo model and another formulated from simulated galaxy clustering of a semi-analytical model, $\mathcal {F}_{HM}$ and $\mathcal {F}_{\it SAM}$, respectively). We find that the best model combination employing $\mathcal {F}_{HM}$ is $P_{dw}(k|k_*)*\mathcal {F}_{HM}*\mathcal {M}_B$, while the best combination employing $\mathcal {F}_{\it SAM}$ is $P_{dw}(k|k_*)*\mathcal {F}_{\it SAM}*\mathcal {M}_B$, which leads to unbiased measurements of cosmological parameters. We compare these to the Effective Field Theory of Large-Scale Structure perturbation theory model PEFT(k|Θ), and find that our simple phenomenological models are comparable across the entire redshift range for kmax = 0.25 and 0.3 h Mpc−1. We expect the tools that we have developed to be useful in probing dark energy and testing gravity using Roman in an accurate and robust manner.
Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report
Authors: Doak Shareen H , Andreoli Cristina , Burgum Michael J , Chaudhry Qasim , Bleeker Eric A J , Bossa Cecilia , Domenech Josefa , Drobne Damjana , Fessard Valérie , Jeliazkova Nina , Longhin Eleonora , Rundén-Pran Elise , Stępnik Maciej , El Yamani Naouale , Catalán Julia , Dusinska Maria 
Published: May 2023

Abstract
Genotoxicity testing for nanomaterials remains challenging as standard testing approaches require some adaptation, and further development of nano-specific OECD Test Guidelines (TGs) and Guidance Documents (GDs) are needed. However, the field of genotoxicology continues to progress and new approach methodologies (NAMs) are being developed that could provide relevant information on the range of mechanisms of genotoxic action that may be imparted by nanomaterials. There is a recognition of the need for implementation of new and/or adapted OECD TGs, new OECD GDs, and utilization of NAMs within a genotoxicity testing framework for nanomaterials. As such, the requirements to apply new experimental approaches and data for genotoxicity assessment of nanomaterials in a regulatory context is neither clear, nor used in practice. Thus, an international workshop with representatives from regulatory agencies, industry, government, and academic scientists was convened to discuss these issues. The expert discussion highlighted the current deficiencies that exist in standard testing approaches within exposure regimes, insufficient physicochemical characterization, lack of demonstration of cell or tissue uptake and internalization, and limitations in the coverage of genotoxic modes of action. Regarding the latter aspect, a consensus was reached on the importance of using NAMs to support the genotoxicity assessment of nanomaterials. Also highlighted was the need for close engagement between scientists and regulators to (i) provide clarity on the regulatory needs, (ii) improve the acceptance and use of NAM-generated data, and (iii) define how NAMs may be used as part of weight of evidence approaches for use in regulatory risk assessments.
Long-Distance Electrical and Calcium Signals Evoked by Hydrogen Peroxide in Physcomitrella
Authors: Koselski Mateusz , Hoernstein Sebastian N. W , Wasko Piotr , Reski Ralf , Trebacz Kazimierz 
Published: May 2023

Abstract
Electrical and calcium signals in plants are some of the basic carriers of information that are transmitted over a long distance. Together with reactive oxygen species (ROS) waves, electrical and calcium signals can participate in cell-to-cell signaling, conveying information about different stimuli, e.g. abiotic stress, pathogen infection or mechanical injury. There is no information on the ability of ROS to evoke systemic electrical or calcium signals in the model moss Physcomitrella nor on the relationships between these responses. Here, we show that the external application of hydrogen peroxide (H2O2) evokes electrical signals in the form of long-distance changes in the membrane potential, which transmit through the plant instantly after stimulation. The responses were calcium-dependent since their generation was inhibited by lanthanum, a calcium channel inhibitor (2 mM), and EDTA, a calcium chelator (0.5 mM). The electrical signals were partially dependent on glutamate receptor (GLR) ion channels since knocking-out the GLR genes only slightly reduced the amplitude of the responses. The basal part of the gametophyte, which is rich in protonema cells, was the most sensitive to H2O2. The measurements carried out on the protonema expressing fluorescent calcium biosensor GCaMP3 proved that calcium signals propagated slowly (&gt;5 µm/s) and showed a decrement. We also demonstrate upregulation of a stress-related gene that appears in a distant section of the moss 8 min after the H2O2 treatment. The results help understand the importance of both types of signals in the transmission of information about the appearance of ROS in the plant cell apoplast.
Pore formation driven by particle impact in laser powder-blown directed energy deposition
Authors: Webster Samantha , Moser Newell , Fezzaa Kamel , Sun Tao , Ehmann Kornel , Garboczi Edward , Cao Jian 
Published: May 2023

Abstract
Process defects currently limit the use of metal additive manufacturing (AM) components in industries due to shorter fatigue life, potential for catastrophic failure, and lower strength. Conditions under which these defects form, and their mechanisms, are starting to be analyzed to improve reliability and structural integrity of these highly customized parts. We use in situ, high-speed X-ray imaging in conjunction with a high throughput laser, powder-blown directed energy deposition setup to observe powder particle impact behavior within the melt pool. Through fundamental observations of the stochastic, violent powder delivery in powder-blown DED, we uncover a unique pore formation mechanism. We find that a pore can form due to air-cushioning, where vapor from the carrier gas or environment is entrapped between the solid powder particle surface and liquid melt pool surface. A critical time constant is established for the mechanism, and X-ray computed tomography is used to further analyze and categorize the new type of “air-cushioning” pores. It is shown that the air-cushioning mechanism can occur under multiple laser processing conditions, and we show that air-cushioning pores are more likely to be formed when powder particles are larger than 70 μm. By quantifying the effect of powder particle impact, we identify new avenues for development of high-quality laser, powder-blown DED products. Furthermore, we deepen knowledge on defect formation in metal additive manufacturing, which is being increasingly utilized in high performance situations such as aerospace, automotive, and biomedical industries.
Mechanical Power Delivered by Noninvasive Ventilation Contributes to Physio-Anatomical and Clinical Responses to Early Versus Late Proning in COVID-19 Pneumonia*
Authors: Musso Giovanni , Taliano Claudio , Paschetta Elena , De Iuliis Marco , Fonti Caterina , Vianou Ines Sarah , Druetta Marta , Riedo Federica , Ferraris Andrea , Tirabassi Gloria 
Published: May 2023

OBJECTIVES:To study: 1) the effect of prone position (PP) on noninvasive ventilation (NIV)-delivered mechanical power (MP) and 2) the impact of MP on physio-anatomical and clinical responses to early versus late PP in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia.DESIGN:Nonrandomized trial with inverse probability of treatment weighted-matched groups.SETTING:HUMANITAS Gradenigo Sub-ICU.PATIENTS:One hundred thirty-eight SARS-CoV-2 pneumonia patients with moderate-to-severe acute hypoxemic respiratory failure (Pao2/Fio2ratio < 200 mm Hg) receiving NIV from September 1, 2020, to February 28, 2021 (Ethics approval: ISRCTN23016116).INTERVENTIONS:Early PP or late PP or supine position.MEASUREMENTS AND MAIN RESULTS:Respiratory parameters were hourly recorded. Time-weighted average MP values were calculated for each ventilatory session. Gas exchange parameters and ventilatory ratio (VR) were measured 1 hour after each postural change. Lung ultrasonographic scores and circulating biomarkers were assessed daily. MP delivered during the initial 24 hours of NIV (MP [first 24 hr]) was the primary exposure variable. Primary outcomes: 28-day endotracheal intubation and death. Secondary outcomes: oxygen-response, Co2-response, ultrasonographic, and systemic inflammatory biomarker responses after 24 hours of NIV. Fifty-eight patients received early PP + NIV, 26 late PP + NIV, and 54 supine NIV. Early PP group had lower 28-day intubation and death than late PP (hazard ratio [HR], 0.35; 95% CI, 0.19–0.69 and HR, 0.26; 95% CI, 0.07–0.67, respectively) and supine group. In Cox multivariate analysis, (MP [first 24 hr]) predicted 28-day intubation (HR, 1.70; 95% CI, 1.25–2.09;p= 0.009) and death (HR, 1.51; 95% CI, 1.19–1.91;p= 0.007). Compared with supine position, PP was associated with a 35% MP reduction. VR, ultrasonographic scores, and inflammatory biomarkers improved after 24 hours of NIV in the early PP, but not in late PP or supine group. A MP (first 24 hr) greater than or equal to 17.9 J/min was associated with 28-day death (area under the curve, 0.92; 95% CI, 0.88–0.96;p< 0.001); cumulative hours of MP greater than or equal to 17.9 J/min delivered before PP initiation attenuated VR, ultrasonographic, and biomarker responses to PP.CONCLUSIONS:MP delivered by NIV during initial 24 hours predicts clinical outcomes. PP curtails MP, but cumulative hours of NIV with MP greater than or equal to 17.9 J/min delivered before PP initiation attenuate the benefits of PP.