bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct assessment of SDO/HMI helioseismology of active regions on the Sun’s far side using SO/PHI magnetograms
Authors: Yang D. , Gizon L. , Barucq H. , Hirzberger J. , Orozco Suárez D. , Albert K. , Albelo Jorge N. , Appourchaux T. , Alvarez-Herrero A. , Blanco Rodríguez J. , Gandorfer A. , Germerott D. , Guerrero L. , Gutierrez-Marques P. , Kahil F. , Kolleck M. , Solanki S. K. , del Toro Iniesta J. C. , Volkmer R. , Woch J. , Pérez-Grande I. , Sanchis Kilders E. , Balaguer Jiménez M. , Bellot Rubio L. R. , Calchetti D. , Carmona M. , Deutsch W. , Feller A. , Fernandez-Rico G. , Fernández-Medina A. , García Parejo P. , Gasent Blesa J. L. , Grauf B. , Heerlein K. , Korpi-Lagg A. , Lange T. , López Jiménez A. , Maue T. , Meller R. , Moreno Vacas A. , Müller R. , Nakai E. , Schmidt W. , Schou J. , Schühle U. , Sinjan J. , Staub J. , Strecker H. , Torralbo I. , Valori G. 
Published: May 2023

Context. Earth-side observations of solar p modes can be used to image and monitor magnetic activity on the Sun’s far side. In this work, we use magnetograms of the far side obtained by the Polarimetric and Helioseismic Imager (PHI) on board Solar Orbiter (SO) to directly assess the validity of far-side helioseismic holography for the first time.
Aims. We wish to co-locate the positions of active regions in helioseismic images and magnetograms and to calibrate the helioseismic measurements in terms of the magnetic field strength.
Methods. We identified three magnetograms displaying a total of six active regions on the far side from 18 November 2020, 3 October 2021, and 3 February 2022. The first two dates are from the SO cruise phase and the third is from the beginning of the nominal operation phase. We computed contemporaneous seismic phase maps for these three dates using helioseismic holography applied to the time series of Dopplergrams from the Helioseismic and Magnetic Imager (HMI) at the Solar Dynamics Observatory (SDO).
Results. Among the six active regions seen in SO/PHI magnetograms, five of them are identified on the seismic maps at almost the same positions as on the magnetograms. One region is too weak to be detected above the seismic noise. To calibrate the seismic maps, we fit a linear relationship between the seismic phase shifts and the unsigned line-of-sight magnetic field averaged over the active region areas extracted from the SO/PHI magnetograms.
Conclusions. SO/PHI provides the strongest evidence so far that helioseismic imaging is able to provide reliable information on active regions on the far side, including their positions, areas, and the mean unsigned magnetic field.
Zufallsfund bei Archivarbeiten – ein Feldpostbrief mit
interessanten Verbindungen
Authors: Baschin Marion , Rath Natalie 
Published: May 2023

ZusammenfassungAusgehend von einem Zufallsfund, einem handschriftlichen Brief, in einer Abgabe
von Unterlagen des Deutschen Zentralvereins homöopathischer
Ärzte wird ein kurzer Einblick in die Arbeiten im
„Homöopathie-Archiv“ des Instituts für
Geschichte der Medizin der Robert Bosch Stiftung gegeben. Inhaltlich wirft das
Schriftstück ein Schlaglicht auf die Thematik Homöopathie und
Krieg.
Pars pro toto – Samuel Hahnemanns Lehre vom
Stellvertreterleid als Grundlage der klassischen
Homöopathie
Authors: Matner Andreas 
Published: May 2023

ZusammenfassungSamuel Hahnemann kam in seiner späten, miasmatischen Schaffensphase zu
dem Ergebnis, dass es zwischen Krankheit und Symptom ein dialektisches
Verhältnis gibt. Er suchte es im Sinne des Pars-pro-toto-Grundsatzes
entelechial zu fassen: Das periphere Lokalsymptom, z. B. das
syphilitische Geschwür (Schanker), vikariiert als Teil das Ganze, das
heißt, es beschwichtigt stellvertretend die unsichtbare Gestalt der
chronischen Krankheit (z. B. der Syphilis) so lange, bis sie
homöopathisch geheilt wird. Wird das Stellvertretersymptom nur –
suppressiv – lokal behandelt, kommt es im Inneren des Organismus zum
Gestaltwandel der Pathologie (Metaschematismus), konkret zur
Verschärfung des ganzen chronischen Krankheitsprozesses.Mit den beiden Begriffen Vikariation und Metaschematismus ist unmittelbar das
Denken der Homöopathie angesprochen. Von hier aus erschließen
sich nicht nur das medizinische Phänomen der Unterdrückung der
primären Krankheitsdynamik, sondern auch die Eigenart und Tradition der
klassischen Homöopathie. Sie ist dadurch gekennzeichnet, dass es ihr
immer um den Zusammenhang zwischen einer ganzheitlichen pathologischen
Problematik (Miasma, Essenz, primäre Psora, Basic Delusion) und ihrer
stellvertretenden symptomatischen Teilerscheinung geht.
Elektrokonvulsionstherapie in der neuen NVL Depression: vom
Unterschied zwischen Effektivität, Evidenz und
Empfehlungsgraden
Authors: Zilles-Wegner David , Sartorius Alexander 
Published: May 2023

ZusammenfassungDie neue Nationale Versorgungsleitlinie (NVL) Unipolare Depression
enthält im Vergleich zur letzten Version von 2015 deutlich
differenziertere Aussagen und Empfehlungen zur Elektrokonvulsionstherapie (EKT).
Dies ist prinzipiell zu begrüßen, da hierdurch der besondere
Stellenwert der EKT in unterschiedlichen klinischen Situationen verdeutlicht
wird. Zugleich führte diese Ausdifferenzierung von Empfehlungen bei
Vorliegen bestimmter Merkmale depressiver Störungen (z. B.
psychotische Symptome, Suizidalität) jedoch dazu, dass in
Abhängigkeit von diesen Merkmalen unterschiedliche Empfehlungsgrade
für die EKT vergeben wurden. Was in der strikten Methodik eines
Leitlinienprozesses richtig und sinnvoll sein mag, kann für die
klinische Praxis teilweise verwirrend und widersprüchlich wirken. In
diesem Beitrag sollen daher die Zusammenhänge sowie vermeintlichen
Diskrepanzen zwischen Effektivität der EKT, wissenschaftlicher Evidenz
und Empfehlungsgrad der Leitlinie dargelegt und für die klinische
Anwendung aus Expertensicht kommentiert werden.
Development of an Immune Prognostic Model for Clear Cell Renal Cell Carcinoma Based on Tumor Microenvironment
Authors: Wang Munan , Song Qianqian , Song Zhijie , Xie Yuduan 
Published: May 2023

AbstractImmune infiltration remains at a high level in clear cell renal cell carcinoma (ccRCC). It has been confirmed that immune cell infiltration in tumor microenvironment (TME) is intimately bound up with the progression and the clinical outcome of ccRCC. The prognostic model, developed based on different immune subtypes of ccRCC, has a predictive value in patients’ prognosis. RNA sequencing data, somatic mutation data of ccRCC and clinical information were acquired from the cancer genome atlas (TCGA) database. The key immune-related genes (IRGs) were selected and by univariate Cox, LASSO, and multivariate Cox regression analyses. Then the ccRCC prognostic model was developed. The applicability of this model was verified in the independent dataset GSE29609. Thirteen IRGs including CCL7, ATP6V1C2, ATP2B3, ELAVL2, SLC22A8, DPP6, EREG, SERPINA7, PAGE2B, ADCYAP1, ZNF560, MUC20, and ANKRD30A were finally selected and a 13-IRGs prognostic model was developed. Survival analysis demonstrated that when compared with the low-risk group, patients in the high-risk group had a lower overall survival (p<0.05). AUC values based on the 13-IRGs prognostic model used to predict 3- and 5-year survival of ccRCC patients were greater than 0.70. And risk score was an independent prognostic factor (p<0.001). In addition, nomogram could accurately predict ccRCC patient’s prognosis. This 13-IRGs model can effectively evaluate the prognosis of ccRCC patients, and also provide guidance for the treatment and prognosis of ccRCC patients.
Adipose Tissue-Derived Stromal/Stem Cells Transplantation
with Cholecalciferol Supplementation in Recent-Onset Type 1 Diabetes Patients:
Twelve Months Follow-Up
Authors: Dantas Joana R. , Araujo Debora Batista , Silva Karina Ribeiro , Souto Debora Lopes , Pereira Maria de Fatima Carvalho , Raggio Luiz Ronir , Claudio-da Silva Cesar , Couri Carlos Eduardo , Maiolino Angelo , Rebellato Carmen Lucia Kuniyoshi , Daga Debora Regina , Senegaglia Alexandra Cristina , Brofman Paulo Roberto Slud , Baptista Leandra S. , Oliveira Jose Egidio Paulo de , Zajdenverg Lenita , Rodacki Melanie 
Published: May 2023

AbstractTo evaluate safety and therapeutic effect along 12 months of allogenic adipose
tissue-derived stromal/stem cells (ASCs) transplantation with
cholecalciferol (VITD) in patients with recent-onset type 1 diabetes (T1D).
Prospective, phase II, open trial, pilot study in which patients with recent
onset T1D received ASCs (1xKgx106 cells) and VITD 2000UI/day
for 12 months (group 1) and were compared to controls with standard insulin
therapy (group 2). Adverse events, C-peptide area under the curve (CPAUC),
insulin dose, HbA1c and frequency of FoxP3+ in CD4+ or
CD8+ T-cells(flow cytometry) were evaluated at baseline(T0), after
3(T3), 6(T6) and 12 months(T12). Eleven patients completed follow up (7:group
1;4:group 2). Group 1 had lower insulin requirement at
T3(0.24±0.18vs0.53±0.23UI/kg,p=0.04),
T6(0.24±0.15vs0.66±0.33 UI/kg,p=0.04) and
T12(0.39±0.15vs0.74±0.29 UI/Kg,p=0.04).HbA1c was
lower at T6
(50.57±8.56vs72.25±10.34 mmol/mol,p=0.01),
without differences at T12 (57.14±11.98 in group 1 vs.
73.5±14.57 mmol/min in group 2, p=0.16). CPAUC
was not significantly different between groups at T0(p=0.07), higher in
group 1 at T3(p=0.04) and T6(p=0.006), but similar at
T12(p=0.23). IDAA1c was significantly lower in group 1 than group 2 at
T3,T6 and T12 (p=0.006, 0.006 and 0.042, respectively). IDDA1c was
inversely correlated to FoxP3 expression in CD4 and CD8+ T cells at T6
(p<0.001 and p=0.01, respectively). In group 1, one patient had
recurrence of a benign teratoma that was surgically removed, not associated to
the intervention. ASCs with VITD without immunosuppression were safe and
associated lower insulin requirements, better glycemic control, and transient
better pancreatic function in recent onset T1D, but the potential benefits were
not sustained.
Practice Changes Induced by a Traveling Fellowship
Authors: Hollyer Ian , Cabell Akaila C. , Duncan Stephen T. , Rossi Stefano M. P. , Sculco Peter K. , Barnes C. Lowry , Amanatullah Derek F. 
Published: May 2023

AbstractThe John N. Insall Knee Society Traveling Fellowship selects four international arthroplasty or sports fellowship-trained orthopaedic surgeons to spend 1 month traveling to various Knee Society members' joint replacement and knee surgery centers in North America. The fellowship aims to foster research and education and shares ideas among fellows and Knee Society members. The role of such traveling fellowships on surgeon preferences has yet to be investigated. A 59-question survey encompassing patient selection, preoperative planning, intraoperative techniques, and postoperative protocols was completed by the four 2018 Insall Traveling Fellows before and immediately after the completion of traveling fellowship to assess anticipated practice changes (e.g., initial excitement) related to their participation in a traveling fellowship. The same survey was completed 4 years after the completion of the traveling fellowship to assess the implementation of the anticipated practice changes. Survey questions were divided into two groups based on levels of evidence in the literature. Immediately after fellowship, there was a median of 6.5 (range: 3–12) anticipated changes in consensus topics and a median of 14.5 (range: 5–17) anticipated changes in controversial topics. There was no statistical difference in the excitement to change consensus or controversial topics (p = 0.921). Four years after completing a traveling fellowship, a median of 2.5 (range: 0–3) consensus topics and 4 (range: 2–6) controversial topics were implemented. There was no statistical difference in the implementation of consensus or controversial topics (p = 0.709). There was a statistically significant decline in the implementation of changes in consensus and controversial preferences compared with the initial level of excitement (p = 0.038 and 0.031, respectively). After the John N. Insall Knee Society Traveling Fellowship, there is excitement for practice change in consensus and controversial topics related to total knee arthroplasty. However, few practice changes that had initial excitement were implemented after 4-year follow-up. Ultimately, the effects of time, practice inertia, and institutional friction overcome most of the anticipated changes induced by a traveling fellowship.
Interference Screw versus Cement Fixation in Anterior Cruciate Ligament Soft Tissue Grafts: A Biomechanical Study
Authors: Patel Jay , Kadkoy Yazan , Helbig Thomas , Rupani Mohammed , Cuppari Nicholas , Cortes Ricardo , Wetterstrand Charlene , Lu Michael T. , Paglia David N. , Galdi Balazs , Beiro Cristobal 
Published: May 2023

AbstractShortcomings of fixation have been reported as a source of graft failure in anterior cruciate ligament (ACL) reconstruction. While interference screws have long been used as fixation devices for ACL reconstruction, they are not without complications. Previous studies have highlighted the use of bone void filler as a fixation method; however, no biomechanical comparisons using soft tissue grafts with interference screws exist to our knowledge. The purpose of this study is to evaluate the fixation strength of a calcium phosphate cement bone void filler compared with screw fixation in an ACL reconstruction bone replica model with human soft tissue grafts. In total, 10 ACL grafts were constructed using semitendinosus and gracilis tendons harvested from 10 donors. Grafts were affixed with either an 8–10 mm × 23 mm polyether ether ketone interference screw (n = 5) or with approximately 8 mL of calcium phosphate cement (n = 5) into open cell polyurethane blocks. Graft constructs were tested to failure in cyclic loading under displacement control at a rate of 1 mm per second. When compared with screw construct, the cement construct showed a 978% higher load at yield, 228% higher load at failure, 181% higher displacement at yield, 233% higher work at failure, and a 545% higher stiffness. Normalized data for the screw constructs relative to the cement constructs from the same donor showed 14 ± 11% load at yield, 54 ± 38% load at failure, and 172 ± 14% graft elongation. The results of this study indicate that cement fixation of ACL grafts may result in a stronger construct compared with the current standard of fixation with interference screws. This method could potentially reduce the incidence of complications associated with interface screw placement such as bone tunnel widening, screw migration, and screw breakage.
Total Knee Conversion Rates and Functional Outcome After Calcium Phosphate Injection for Bone Marrow Lesions of the Knee
Authors: Stratton Alex , Wanless Malcolm , Abidi Nicholas 
Published: May 2023

AbstractUntreated osteoarthritis (OA)-related bone marrow lesions (OA-BML) can hasten the progression of knee OA. Previous studies have shown that fluoroscopically guided intraosseous calcium-phosphate (CaP) injections of OA-BML during knee arthroscopy can lead to pain reduction, improved functionality, and prolonged time until conversion to total knee arthroplasty (TKA). The purpose of this retrospective study is to compare the clinical outcomes of patients who underwent knee arthroscopy and CaP injection for OA-BML versus knee arthroscopy for non-OA-BML pathologies. Two-year follow-up data and patient-reported outcomes including knee injury and operative outcome scores, joint replacement scores (KOOS, JR) were available for 53 patients in the CaP group and 30 patients in the knee arthroscopy group. Results indicate that patients in the CaP group had less frequent conversion to TKA compared with patients in the knee arthroscopy group. Statistical analysis demonstrated a statistical difference between preoperative and postoperative KOOS, JR within the CaP group but not for the knee arthroscopy group. Two-year postoperative KOOS, JR for CaP patients was statistically greater than the 2-year postoperative KOOS, JR of knee arthroscopy patients. Results indicate greater improvement in functional outcomes with knee arthroscopy and CaP injection of OA-BML compared with knee arthroscopy alone for non-OA-BML diagnoses. The results of this retrospective study help to distinguish the benefits of knee arthroscopy accompanied by CaP intraosseous injection from that of knee arthroscopy alone.
Similar Midterm Outcomes of Total Knee Arthroplasties with Anterior and Posterior Tibial Slopes Performed on Paired Knees at a Minimum Follow-up of 5 Years
Authors: Song Sang Jun , Bae Dae Kyung , Hwang Sung Hyun , Park Hong Sik , Park Cheol Hee 
Published: May 2023

AbstractA small posterior tibial slope (PTS) is generally recommended in posterior stabilized (PS) total knee arthroplasty (TKA). An unwanted anterior tibial slope (ATS), which can affect postoperative results, may be created in PS TKA because of the inaccuracy of surgical instruments and techniques, as well as high interpatient variability. We compared midterm clinical and radiographic results of PS TKAs with ATS and PTS performed on paired knees using the same prosthesis. One-hundred-twenty-four patients who underwent TKAs with ATS and PTS on paired knees using ATTUNE posterior-stabilized prostheses were retrospectively reviewed after a minimum follow-up period of 5 years. The mean follow-up period was 5.4 years. The Knee Society Knee and Function scores, Western Ontario and McMaster Universities Osteoarthritis Index, Feller and Kujalar scores, and range of motion (ROM) were evaluated. The preferred TKA out of ATS and PTS was also investigated. The hip-knee-ankle angle, component positions, tibial slope, posterior femoral offset, Insall–Salvati ratio, and knee sagittal angle were measured by radiography. There were no significant differences in the clinical results, including ROM, between TKAs with ATS and PTS preoperatively and at the last follow-up. Regarding patient preference, 58 patients (46.8%) were satisfied with bilateral knees, 30 (24.2%) preferred knees with ATS, and 36 (29%) preferred knees with PTS. There was no significant difference in the rate of preference between TKAs with ATS and PTS (p = 0.539). Except for the postoperative tibial slope (−1.8 vs. 2.5 degrees, p < 0.001), there were also no significant differences in the radiographic results, including the knee sagittal angle, preoperatively and at the last follow-up. The midterm outcomes were similar between PS TKAs with ATS and PTS performed on paired knees at a minimum of 5 years of follow-up. Nonsevere ATS did not affect midterm outcomes in PS TKA with proper soft tissue balancing and the current prosthesis of improved design. However, a long-term follow-up study is required to confirm the safety of nonsevere ATS in PS TKA.
Level of Evidence: III
The Accuracy of a Portable Accelerometer-Based Navigation System for Tibial Alignment Can be Reliable during Total Knee Arthroplasty for Obese Patients
Authors: Goto Kazumi , Hirota Jinso , Miyamoto Yoshinari , Katsuragawa Yozo 
Published: May 2023

AbstractA portable accelerometer-based navigation system can be useful for achieving the target alignment. Tibial registration is based on the medial and lateral malleoli; however, the identification of landmarks may be difficult in obese (body mass index [BMI] >30 kg/m2) patients whose bones are not easily palpable from the body surface. This study compared tibial component alignment achieved using a portable accelerometer-based navigation system (Knee Align 2 [KA2]) in obese and control groups and aimed to validate the accuracy of bone cutting in obese patients. A total of 210 knees that underwent primary total knee arthroplasty using the KA2 system were included. After 1:3 propensity score matching, there were 32 and 96 knees in the BMI >30 group (group O) and BMI ≤30 group (group C), respectively. The absolute deviations of the tibial implant from the intended alignment were evaluated in the coronal plane (hip–knee–ankle [HKA] angle and medial proximal tibial angle) and sagittal plane (posterior tibial slope [PTS]). The inlier rate of each cohort, which was defined as tibial component alignment within 2 degrees of the intended alignment, was investigated. In the coronal plane, the absolute deviations of the HKA and MPTA from the intended alignment were 2.2 ± 1.8 degrees and 1.8 ± 1.5 degrees in group C and 1.7 ± 1.5 degrees and 1.7 ± 1.0 degrees in group O (p = 1.26, and p = 0.532). In the sagittal plane, the absolute deviations of the tibial implant were 1.6 ± 1.2 degrees in group C and 1.5 ± 1.1 degrees in group O (p = 0.570). The inlier rate was not significantly different between group C and group O (HKA: 64.6 vs. 71.9%, p = 0.521; MPTA: 67.7 vs. 78.1%, p = 0.372; PTS: 82.2 vs. 77.8%, p = 0.667). The accuracy of tibial bone cutting for the obese group was comparable to that of the control group. An accelerometer-based portable navigation system can be useful when attempting to achieve the target tibial alignment in obese patients.
Level of Evidence Level IV.
Nickel-Catalyzed Electrochemical Cyclizative Carboxylation of Alkene-Tethered Carbamoyl Chlorides with Carbon Dioxide
Authors: Wang Lin-Lin , Liu Xiao-Fei , Zhang Wen-Zhen , Wang He , Tao Li , Huang Jian , Ren Wei-Min , Lu Xiao-Bing 
Published: May 2023

AbstractNickel-catalyzed electrochemical cyclizative carboxylation of alkene-tethered carbamoyl chlorides with atmospheric carbon dioxide in an undivided cell under simple constant current conditions is reported. This reaction is conducted with high efficiency under mild conditions, providing a convenient and green access to valuable 2-oxoindolin-3-ylacetic acids and 2-oxo-tetrahydroquinoline-4-carboxylic acids.
Unilateral Thyroid Lobectomy as Day Care Procedure: A Cross Sectional Study with Literature Review on the Safety and Cost Effectiveness
Authors: Mughal Ainulakbar , Vardag Abdul Basit Shah , Deewani Muhammad Hammad , Wasif Muhammad , Mughal Marhaba , Awan Sohail , Unar Ambreen 
Published: May 2023

Abstract
Introduction Thyroid nodules are common globally in almost one fifth of the adult population. The gold standard treatment for thyroid nodule is thyroid lobectomy or total thyroidectomy depending upon the diagnosis. Thyroidectomy has a few known complications but, as per the ATA consensus statement, it is a safe surgery to be done as a day care procedure.
Objective To access the feasibility and safety of thyroid lobectomy as a day care surgery and its effect on decreasing overall financial burdens.
Methods This retrospective chart review was done from 2006 to 2022. A total of 736 patients underwent thyroid lobectomy among which only 56 were done as day care surgery. Data analysis was done using the IBM SPSS Statistics for Windows, Version 23.0 (IBM Corp., Armonk, NY, USA).
Results A total of 40% of the population was male. The mean age of the study population was 42 years. Bethesda II was the most encountered diagnosis, with a rate of 69%. The majority of patients were discharged after 6 hours of postoperative observation. The only complication encountered was seroma, which was seen in two patients.
Conclusion Thyroid lobectomy appears to be a safe procedure with a drastic difference in overall cost as a day care procedure. We recommend switching the practice of inpatient thyroid lobectomy to a day care procedure in carefully selected candidates. The major hurdle in day care lobectomy can be approval from insurance.