bluuebunny/crossref_metadata_2025_split huggingface dataset:
The methodology of the development of original medicines based on the medicinal plant raw material for the treatment of inflammatory bowel diseases
Authors: Shmalko O. O. 
Published: September 2023

According to the Ministry of Health of Ukraine, the number of patients with IBD in Ukraine is approximately 30,000 people per 100,000 population, half of which have a medium or severe degree of damage.
Over the past 5 years, there has been a trend towards an increase in the number of severe cases and treatment-resistant forms of chronic intestinal diseases of an inflammatory nature, which often requires surgical intervention or causes the development of complications, which, in turn, can lead to invalidation of patients and, as a result, causes significant economic costs, related to their care, treatment and rehabilitation. The most common are Crohn’s disease and ulcerative colitis.
The prevalence of ulcerative colitis (UC) in the population ranges from 21 to 268 cases per 100,000 people. The social significance of UC lies in the fact that the incidence is predominant among young people. Thus, statistical data show that the peak incidence of UC occurs at the age of 20–30 years. In the absence of appropriate therapy, the course of UC is recurrent and remitting.
In the process of work, the methods of analysis of electronic and paper sources of information were used, on providing the domestic pharmaceutical market with drugs for the treatment of IBD, their directions and mechanism of action, the possibility of using in the therapy of diseases with herbal medicines containing BAS, that affect various links of the pathogenetic process, the possibility of combining it with synthetic API in order to increase the effectiveness of treatment.
The algorithm of the methodology consists of three blocks: information and search, research and biological. Each block, which ends with obtaining an intermediate result, ensures the setting of the task for the next stage of the research.
Molecular analysis with pancreaseq® in evaluation and management of pancreatic cysts: A cohort of 28 patients
Authors: Ardor Gokce Deniz , Hanna Helena , Ozalp Bora , Nassar Aziza 
Published: September 2023

Objectives:
Herein, we present the PancreaSeq® results of 28 patients and emphasize the usefulness of molecular testing in evaluation of pancreatic cysts.

Material and Methods:
A total of 10 (35.7%) non-diagnostic, 6 (21.4%) negative, 5 (17.8%) atypical, and 7 (25%) were positive for mucinous cystic neoplasm (MCN) pancreatic cyst aspirates were analyzed with PancreaSeq® at Mayo Clinic, Jacksonville between September 2021 and February 2023.

Results:
Three non-diagnostic, two negative, three atypical, and two positive for MCN cysts were positive for KRAS and GNAS mutations. They were interpreted as intraductal papillary mucinous neoplasm (IPMN) with low risk for progression to high-grade dysplasia/adenocarcinoma. One negative case was positive for KRAS and GNAS mutation and RNF43 copy number alteration. It was interpreted as IPMN with a low risk of progression. Two non-diagnostic, one negative, and two positive for MCN cysts were positive for KRAS mutation. All were interpreted as IPMN/MCNs with low risk of progression. One positive for MCN case was positive for GNAS mutation and ALK fusion and one positive for MCN case was positive for GNAS mutation, ALK fusion, and RNF43 copy number alteration. Both were interpreted as IPMN and their risk of progression was interpreted as not well understood. One atypical case was positive for KRAS and TP53 mutation and was interpreted as IPMN/ MCNs with a high risk of progression. VHL mutation was present in one non-diagnostic case. It was interpreted as serous cystadenoma and the risk for progression was low.

Conclusion:
Molecular analysis of pancreatic cysts with PancreaSeq® is useful in accurate diagnosis, especially when cytologic material is non-diagnostic and helps improve patient management.
Ruptured small cerebral aneurysm occurring at the fenestration of the A1 portion of the anterior cerebral artery, combined with accessory middle cerebral artery branching from the crus: A case report
Authors: Kimura Seigo , Komiyama Masaki , Taniguchi Hirokatsu , Wanibuchi Masahiko 
Published: September 2023

Background:
Cerebral aneurysms arising from fenestration of the A1 portion of the anterior cerebral artery (ACA) (A1 fenestration) with the accessory middle cerebral artery (MCA) is rare. Herein, we report a ruptured cerebral aneurysm arising from A1 fenestration combined with the accessory MCA that was successfully treated with coil embolization.

Case Description:
A 51-year-old woman suddenly experienced a severe occipital headache and was admitted to our hospital. Detailed examination revealed subarachnoid hemorrhage due to a cerebral aneurysm arising from A1 fenestration combined with the accessory MCA. Hence, coil embolization was performed, and a favorable outcome was obtained.

Conclusion:
Coil embolization of the cerebral aneurysm arising from the A1 fenestration of the ACA combined with the accessory MCA is considered to be useful.
Strategy of cerebral endovascular treatment for cervical internal carotid artery stenosis with a persistent primitive hypoglossal artery
Authors: Yoshida Shinichiro , Kamatani Kaisei , Takigawa Kousuke , Tashiro Noriaki , Hashiguchi Yoshiya , Yasaka Masahiro , Aikawa Hiroshi , Go Yoshinori , Kazekawa Kiyoshi 
Published: September 2023

Background:
Persistent primitive hypoglossal artery (PPHA) is a rare residual arterial anastomosis. We placed a CASPER stent using Spider FX as an embolic protection device (EPD) in a patient with internal carotid artery (ICA) stenosis and PPHA. There are no reports of carotid artery stenting (CAS) using a CASPER stent for ICA stenosis with PPHA. We report the EPD strategy used in this case and the usefulness and precautions of CASPER stent insertion for cervical ICA stenosis in association with PPHA.

Methods:
A 9Fr sheath was placed in the right femoral artery and a 9Fr Branchor balloon guide catheter was guided to the common carotid artery. A Spider FX was placed proximal to the bifurcation of the ICA and the PPHA. A 10 mm × 20 mm CASPER stent was deployed at the site of the stricture with no postoperative ischemic complications.

Results:
There was no intra-stent occlusion, stenosis, or plaque protrusion immediately after surgery, and no postoperative ischemic complications were observed.

Conclusion:
CASPER stent deployment with the Spider FX in the ICA and PPHA bifurcation can be considered to be an effective treatment method for ICA stenosis associated with PPHA. However, care should be taken in selecting the appropriate EPDs and stents depending on the location of the stenosis and bifurcation of the PPHA.
The impact of tax policy on the financing of the education system in the regions of Russia
Authors: Арсаханова З.А. 
Published: September 2023

Российская система образования в последние годы столкнулась с серьезными проблемами, особенно в области финансирования. В статье исследуется влияние налоговой политики на финансирование образования в регионах России. В частности, исследуется текущая налоговая политика в России и то, как финансируется система образования. Также исследуются проблемы, связанные с финансированием образования в регионах России. Затем в статье рассматривается, как налоговая политика влияет на финансирование образования в этих регионах, включая различия в финансировании образования между регионами с разной налоговой политикой. Кроме того, исследуются потенциальные преимущества и недостатки различных налоговых политик в отношении финансирования образования. Статья завершается рекомендациями по улучшению финансирования образования в регионах России, в том числе возможными политическими решениями и корректировками налоговой политики для лучшей поддержки финансирования образования. Инвестиции в финансирование образования в регионах России имеют значительные долгосрочные преимущества.
The Russian education system has faced serious problems in recent years, especially in the field of financing. The article examines the impact of tax policy on the financing of education in the regions of Russia. In particular, it examines the current tax policy in Russia and how the education system is funded. The problems related to the financing of education in the regions of Russia are also investigated. Then the article examines how tax policy affects the financing of education in these regions, including the differences in the financing of education between regions with different tax policies. In addition, the potential advantages and disadvantages of various tax policies in relation to education financing are investigated. The article concludes with recommendations for improving the financing of education in the regions of Russia, including possible policy decisions and adjustments of tax policy to better support the financing of education. Investments in the financing of education in the regions of Russia have significant long-term benefits.
The role of the student in the educational process: participation in conferences
Authors: Быкова И.В. , Зяблова Е.С. , Удовенко Е.В. 
Published: September 2023

Сегодняшний темп жизни набирает большие обороты, давая понять, что люди должны успевать менять себя, свои привычки и уметь быстро адаптироваться к определенным изменениям, которые возникают в обществе. ХХІ век – время стремительного развития инноваций и техники, понимая, что такие процессы являются необратимыми. Встает вопрос - может ли сегодняшний студент совместить в себе два важных направления: науку и активность. Исследуя различные аспекты деятельности студентов, можем сделать вывод, что данную проблему не рассматривали как совокупность факторов, что дает нам возможность исследовать эту проблему более основательно. Наука – это деятельность в системе общественного разделения труда, направленная на получение нового знания с целью оптимизации всей остальной человеческой деятельности. Наука в ее современном понимании возникает постепенно. Активность человека является источником его развития, определяет деятельность и является его движущей силой. Принципиальное различие между этими понятиями состоит в том, что деятельность исходит из потребности в предмете, а активность – из потребности в деятельности. К тому же активность вроде бы предшествует деятельности во времени: до начала деятельности мы активно выбираем, что именно желательно, свободно планируем, думаем, с помощью каких средств чего-то достичь. Но активность не только предшествует деятельности, но и “сопровождает” ее на протяжении всего процесса. Нельзя представить оптимальную деятельность, лишенную активности.
Today's pace of life is gaining momentum, making it clear that people should have time to change themselves, their habits and be able to quickly adapt to certain changes that arise in society. The 21st century is a time of rapid development of innovation and technology, realizing that such processes are irreversible. The question arises whether today's student can combine two important areas: science and activity. Examining various aspects of students' activities, we can conclude that this problem was not considered as a set of factors, which gives us the opportunity to investigate this problem more thoroughly. Science is an activity in the system of social division of labor aimed at obtaining new knowledge in order to optimize all other human activities. Science in its modern understanding arises gradually. Human activity is the source of his development, determines activity and is his driving force. The fundamental difference between these concepts is that activity comes from the need for an object, and activity comes from the need for activity. In addition, activity seems to precede activity in time: before the start of activity, we actively choose what is desirable, freely plan, think by what means to achieve something. But activity not only precedes activity, but also “accompanies” it throughout the entire process. It is impossible to imagine an optimal activity devoid of activity.
Electronic technologies for learning foreign languages
Authors: Коннова О.В. , Романова И.В. 
Published: September 2023

Актуальность выбранной темы обусловлено необходимостью распространения знаний о понимании возможных методов изучения иностранных языков в современном мире. Авторы анализируют различные точки зрения на целесообразность применения электронных технологий в обучении иностранному языку и выражают целостную позицию по данному вопросу. В статье рассматриваются как положительные, так и отрицательные стороны внедрения электронных методик обучения в образовательный процесс. В статье рассматриваются различные аспекты, такие как использование компьютерных программ, интерактивных учебных платформ, онлайн-ресурсов и мобильных приложений для эффективного изучения языков. Авторы анализируют преимущества и ограничения электронных технологий в контексте обучения иностранным языкам, а также обсуждают вопросы эффективности и результативности такого подхода. Статья является полезным ресурсом для преподавателей и исследователей, интересующихся применением современных технологий в образовании и изучении иностранных языков.
The relevance of the chosen topic is due to the need to disseminate knowledge about the understanding of possible methods of learning foreign languages in the modern world. The authors analyze various points of view on the expediency of using electronic technologies in teaching a foreign language and express a holistic position on this issue. The article discusses both positive and negative aspects of the introduction of electronic teaching methods in the educational process. The article discusses various aspects, such as the use of computer programs, interactive learning platforms, online resources and mobile applications for effective language learning. The authors analyze the advantages and limitations of electronic technologies in the context of teaching foreign languages, as well as discuss the effectiveness and effectiveness of such an approach. The article is a useful resource for teachers and researchers interested in the use of modern technologies in education and learning foreign languages.
Consumer Perceptions and Behaviors on Digital Payment Adoption Among Older Generation Z and Younger Millennials in Phnom Penh, Cambodia
Authors: Leang Pisey , Ramsamy Siva Shankar , Phaphuangwittayakul Aniwat , Loahavilai Piang-or 
Published: September 2023

Purpose: The study's goal is to better understand how older and younger generations in Phnom Penh, Cambodia, behave when it comes to using digital payments. Investigating the choice of mobile payment application in the Phnom Penh region is another objective of this study. Here, it is also investigated how usage, economic situation, and adoption of mobile payments are related.

Theoretical framework: One of the most well-known research models on consumer behavior among younger and older generations and the adoption of new technical systems emphasizes the influence of geography, socioeconomic status, and specific traits on consumer acceptance. The concept considers factors including social effects, credibility requirements, effort expectations, and performance requirements when determining the best digital payment application.

Design/Methodology/Approach: The Unified Theory of Acceptance and Use of Technology (UTAUT) model and K-mean clustering for distance and economic status studies were used in this research paper to select 150 locals in Phnom Penh from the target population in order to study consumer behavioral intention to accept digital payment method and application.

Findings: The result we aimed to show and analyses the Digital payment methods, payments sharing, receiving, storing evidences, that older generation started understanding the digital payment by Khmer language and accepting the digital transactions from known customers. The current generation using Sathapana application and English Language in wide ranges through the Phom Penh region. The study also trying to exhibit the purpose of the digital payment systems in and across the e-commerce activities, through the older and younger generation.

Research, Practical & Social implications: The elder generation Z handled digital payments for regional transactions like banking, home tasks, loan repayment, peer lending, travel, and local marketplaces in Khmer. The subsequent generations of millennials also incorporated cross-border payments in English and Khmer.

Originality/Value: Bringing up a Digital Platform shall make a positive change in economy and circulation of economy to the people and country. Unless the people trust the digital payments, they cant share their money for the business or basic operations to run the government. Thy the Digital Payment applications shall understand the behavior of the customers and share the services through the digital payment systems.
Study of Immersion in Augmented Reality Through Analysis of Immersion Elements in Museums
Authors: Zhang Xiaofan 
Published: September 2023

With the advent of the information age, augmented reality technology can enhance the sense of reality in the virtual world and immerse people in the real and virtual world. People have always been interested in virtual space or augmented reality technology, especially in the face of historical development trends. Museums have always been open to the public, they are not just a collection, but also an exhibition for the public. Through analyzing different museums, it is found that museums with augmented reality technology exhibitions are non-profit museums for the purpose of emotional experience. In order to find out the immersion factors of virtual reality in museums, on the basis of previous research, this paper divides immersion in augmented reality into story immersion, five-sense experience immersion, and spatial interaction immersion. Through the analysis of different museums, it is found that immersion through five-sense experience is the most commonly used method when all display media are included. This method provides educational content for museum visitors and projects virtual presentations through monitors and portable IT devices, thereby increasing visitors’ viewing pleasure.
Território Barra da Tijuca: do sertão carioca aos condomínios fechados
Authors: De Mendonca Valeria 
Published: September 2023

Parte da pesquisa Território e territorialidade: do “sertão carioca” aos condomínios fechados da Barra da Tijuca, este artigo tem como cenário dois condomínios da Zona Oeste do Rio de Janeiro – Barra Sul e Pontões da Barra –, situados lado a lado no bairro da Barra da Tijuca, Rio de Janeiro. Inicialmente, foram resgatadas as primeiras formações populacionais no território pesquisado, com intuito de aprofundarem-se as significações sociais construídas, bem como de verificarem-se as características sociais e culturais emergentes, incluindo as dinâmicas organizacionais dos sujeitos que ali habitam. Daí a ênfase no conceito de espaço como intercessório e passível de ser atravessado por outras significações, que acabam por lhe conferir diferentes ângulos e significados. A metodologia liga-se à vertente de pesquisa qualitativa e participativa, voltada às questões temáticas sobre o cotidiano social em seus desdobramentos culturais e identitários. Para isso, fez-se um mapeamento das potencialidades dos locais estudados e dos usuários que ali moram ou transitam, por meio da análise de entrevistas, como forma de incorporar a dimensão subjetiva ao território espacial, numa aproximação dos territórios vividos e construídos. Por ser um bairro planejado para preservar áreas públicas e manter um distanciamento padrão entre as construções, a Barra da Tijuca volta para a promoção de um estilo de vida que visa a um bem-estar e a uma qualidade de vida na integração Homem/Natureza. Sua geografia, com uma grande planície cercada por mar, lagoas e montanhas, favoreceu a construção de condomínios, de shoppings e de grandes vias de circulação de veículos; contudo, a maior particularidade dessa área é seu caráter de diversificação, unindo várias classes sociais que por ali moram/circulam/estudam/trabalham. Por ter sua história documentada, incluindo as povoações e a composição geográfica do início do século XVII, a área permite uma pesquisa direcionada à composição social e territorial.
Translating Transitivity of Indonesian Tourism Texts and Its English Translation : A Case in Madura
Authors: Sriyono Sriyono 
Published: September 2023

Abstract. This research aims at investigating the translation of the transitivity system of Madura tourism texts from Indonesian as the Source Text (ST) into English as the Target Text (TT). Besides, this also purposes to study how the transitivity as the representation of experiential meaning in tourism texts is realized and translated. The method used in this research is qualitative descriptive, while the data were taken from tourism texts of promotional media in Madura. Accordingly, Systemic Functional Linguistics (SFL) is pondered as a tool to identify the transitivity system and its translation of tourism promotion media in Madura. This study shows that the transitivity in tourism texts is translated differently which results in the realization of experiential meaning expression between ST and TT. Most of the experiential meaning in ST are realized with the relational process and as well as in the TT. Transposition and modulation in terms of translation technique also influence the differences of the understanding of readers (tourists) to the object promoted in Madura. Therefore, the process and participant in the transitivity system found ST and TT also generates the dissimilarities interpretation of experiential meaning and point of view in Indonesian tourism texts and its English translation. Keywords: transitivity; translation; tourism texts
Multimodal Feedback on speaking: Effectiveness and Students’ Perspective
Authors: Syafryadin Syafryadin , Wardhana Dian Eka Chandra 
Published: September 2023

Abstract. Multimodal feedback needs to be studied and researched to enhance student’s ability. Thus, this research aims to examine the feedback which using technology and conventional without using technology in speaking, wanted to explore how multimodal feedback could influence the students’ speaking ability, know the student’s perception on multimodal feedback and the reason multimodal feedback could improve students’ speaking ability. The research used a sequential mixed method design with test and interview as instruments. The sample was 54 students for experimental and control group. The result showed that there is not significant different between multimodal feedback with using technology and without using technology. However, in terms of mean score, multimodal feedback with using technology is higher than multimodal feedback without using technology on improving students’ speaking ability. Another result showed that the students had positive response towards the use of multimodal feedback on learning speaking because it can give them much knowledge and upgrade their ability in speaking class. Keywords: Multimodal feedback; using technology; speaking ability