bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining themes of social media users' opinion on remote work during COVID-19 pandemic: a justice theory perspective
Authors: Xing Yunfei , He Yuming , Zhang Justin Z. 
Published: September 2023

PurposeThe coronavirus disease 2019 (COVID-19) pandemic caused significant disruption to the global labor market, resulting in a rapid transition toward remote work, e-commerce and workforce automation. This shift has sparked a considerable amount of public discussion. This study aims to explore the online public's sentiment toward remote work amid the pandemic.Design/methodology/approachBased on justice theory, this paper examines user-generated content on social media platforms, particularly Twitter, to gain insight into public opinion and discourse surrounding remote work during the COVID-19 pandemic. Employing content analysis techniques such as sentiment analysis, text clustering and evolutionary analysis, this study aims to identify prevalent topics, temporal patterns and instances of sentiment polarization in tweets.FindingsResults show that people with positive opinions focus mainly on personal interests, while others focus on the interests of the company and society; people's subjectivities are higher when they express extremely negative or extremely positive emotions. Distributive justice and interactional justice are distinguishable with a high degree of differentiation in the cluster map.Originality/valuePrevious research has inadequately addressed public apprehensions about remote work during emergencies, particularly from a justice-based perspective. This study seeks to fill this gap by examining how justice theory can shed light on the public's views regarding corporate policy-making during emergencies. The results of this study provide valuable insights and guidance for managing public opinion during such events.
A parallel ring-ring capacitive proximity sensor for detection of approaching conductor
Authors: Shi Yanyan , Huang Fenglan , Wang Meng , Li Yongheng 
Published: September 2023

Purpose
To solve the problem of low sensitivity of traditional capacitive proximity sensor, this paper aims to propose a novel capacitive sensor for detection of an approaching conductor.

Design/methodology/approach
Five capacitive proximity sensors with different structures are designed and the performance is compared with the traditional capacitive sensor. The impacts of geometrical parameters on the performance of the proposed capacitive sensor are studied. Furthermore, the sensitivity of the proposed capacitive sensor to an approaching conductor with different sizes is discussed. Also, how the designed capacitive sensor is sensitive to the lateral placement of the approaching object is analyzed.

Findings
Several capacitive proximity sensor structures have been designed and analyzed. It is found that the capacitive sensor with the top small ring-bottom large ring structure shows stronger electric field distribution around the top electrode and higher sensitivity to the approaching conductor than other sensors. Through further analysis of the proposed sensor, the results demonstrate that proposed capacitive sensor is effective for proximity object detection.

Originality/value
This paper proposes a novel capacitive proximity sensor with top small ring-bottom large ring structure. Compared with the traditional capacitive sensor, the proposed capacitive sensor is more sensitive to the approaching object. This would be helpful for the accurate detection of the approaching object. Also, the top and bottom electrodes are much smaller.
Microbial dynamics in soils of the Damma glacier forefield show succession in the functional genetic potential
Authors: Feng Maomao , Varliero Gilda , Qi Weihong , Stierli Beat , Edwards Arwyn , Robinson Serina , van der Heijden Marcel G. A. , Frey Beat 
Published: September 2023

AbstractGlacier retreat is a visible consequence of climate change worldwide. Although taxonomic change of the soil microbiomes in glacier forefields have been widely documented, how microbial genetic potential changes along succession is little known. Here, we used shotgun metagenomics to analyse whether the soil microbial genetic potential differed between four stages of soil development (SSD) sampled along three transects in the Damma glacier forefield (Switzerland). The SSDs were characterized by an increasing vegetation cover, from barren soil, to biological soil crust, to sparsely vegetated soil and finally to vegetated soil. Results suggested that SSD significantly influenced microbial genetic potential, with the lowest functional diversity surprisingly occurring in the vegetated soils. Overall, carbohydrate metabolism and secondary metabolite biosynthesis genes overrepresented in vegetated soils, which could be partly attributed to plant–soil feedbacks. For C degradation, glycoside hydrolase genes enriched in vegetated soils, while auxiliary activity and carbohydrate esterases genes overrepresented in barren soils, suggested high labile C degradation potential in vegetated, and high recalcitrant C degradation potential in barren soils. For N‐cycling, organic N degradation and synthesis genes dominated along succession, and gene families involved in nitrification were overrepresented in barren soils. Our study provides new insights into how the microbial genetic potential changes during soil formation along the Damma glacier forefield.
The relative importance of information events: An ex ante perspective
Authors: Iselin Michael , Van Buskirk Andrew 
Published: September 2023

AbstractWe build on recent advances in options pricing research to propose a novel measure of the ex ante relative importance of information events. Our firm‐level measure captures the extent to which investors view an event as important, independent of its realized outcome. We first validate the measure and then demonstrate how it can be used to (1) study heterogeneity across firms in the relative importance of information events; (2) identify firms for which an event was important, even though the realized outcome did not result in a meaningful stock reaction; and (3) examine questions about how the importance of an event impacts firm decisions, where using realized return‐based measures of event importance would result in an endogeneity problem.
Intact mitochondrial function in the setting of telomere‐induced senescence
Authors: Sullivan Daniel I. , Bello Fiona M. , Silva Agustin Gil , Redding Kevin M. , Giordano Luca , Hinchie Angela M. , Loughridge Kelly E. , Mora Ana L. , Königshoff Melanie , Kaufman Brett A. , Jurczak Michael J. , Alder Jonathan K. 
Published: September 2023

AbstractMitochondria play essential roles in metabolic support and signaling within all cells. Congenital and acquired defects in mitochondria are responsible for several pathologies, including premature entrance to cellar senescence. Conversely, we examined the consequences of dysfunctional telomere‐driven cellular senescence on mitochondrial biogenesis and function. We drove senescence in vitro and in vivo by deleting the telomere‐binding protein TRF2 in fibroblasts and hepatocytes, respectively. Deletion of TRF2 led to a robust DNA damage response, global changes in transcription, and induction of cellular senescence. In vitro, senescent cells had significant increases in mitochondrial respiratory capacity driven by increased cellular and mitochondrial volume. Hepatocytes with dysfunctional telomeres maintained their mitochondrial respiratory capacity in vivo, whether measured in intact cells or purified mitochondria. Induction of senescence led to the upregulation of overlapping and distinct genes in fibroblasts and hepatocytes, but transcripts related to mitochondria were preserved. Our results support that mitochondrial function and activity are preserved in telomere dysfunction‐induced senescence, which may facilitate continued cellular functions.
Seed dispersal of a fleshy‐fruited invasive shrub is affected by changes in the frugivorous bird assemblage along an elevational gradient
Authors: Juncosa‐Polzella Agostina S. , Tecco Paula A. , Vergara‐Tabares David L. 
Published: September 2023

AbstractSeed dispersal by birds constitutes an essential mechanism for ornithochorous exotic plants to successfully invade a new system. New biotic associations with native birds might facilitate the upward spread of exotic plants from the foothills into the high mountains. However, environmental changes associated with elevation are known to drive changes in bird assemblages, and it is not clear how elevation changes impact the seed dispersal service of ornithochorous invaders. We evaluated changes in frugivorous bird assemblages of one of the exotic shrubs (Cotoneaster franchetii, Rosaceae) with the broadest elevation range among woody invaders in the Córdoba Mountains (Argentina). We quantified frugivory interactions (including absolute and proportional fruit consumption by seed dispersers, pulp consumers, and seed predators) using 4‐h observations of focal C. franchetii shrubs distributed across low‐elevation, mid‐elevation, and high‐elevation sites (700, 1100, and 1800 m a.s.l., respectively; 15 individuals per elevational band and one site per elevation). Seed disperser richness was highest at the low‐ and mid‐elevation sites (three species vs. one at the high‐elevation site), but proportional and absolute fruit consumption of C. franchetii was highest at the high‐elevation site (39.1%, 88 seeds at high‐elevation and 7.7%, 20 seeds at low‐elevation). The Chiguanco Thrush (Turdus chiguanco, Turdidae) was the only seed disperser species found at the highest elevation site. Fruit consumption by seed dispersers was positively related to their abundance and elevation. In a high mountain system, a single abundant generalist seed disperser, rather than a high richness of seed disperser species, can uphold an effective dispersal service for an invasive ornithochorous shrub. This pattern may facilitate the spread of such plants across higher elevational ranges, thereby promoting the invasion of other exotic ornithochorous plants into upper elevations.
A comprehensive study on the arterial vasculature of the brain in water buffalo (Bubalus bubalis): Clinical correlates
Authors: John Masuood Ahmad , Rashid Rakshan , Malik Abrar A. , Sasan Jasvinder Singh , Mir Abdul Qayoom , Choudhury Abdur Rezzaque , Dar Firdous Ahmad , Rafiq Andleeb , Mahdy Mohamed A. A. 
Published: September 2023

AbstractThe present study was designed to provide a comprehensive analysis of the anatomical aspects of arterial blood vasculature in the water buffalo brains. Fifty cranial cavities of adult water buffaloes were opened via both the dorsal and ventral approaches and the arteries were exposed and photographed. The buffalo rostral epidural rete mirabile generally resembled that of large ruminants. The oculomotor, abducent and trigeminal nerves were intimately associated with the rostral rete. Similar to the majority of ruminants, the arterial circle of the brain was heart‐shaped in buffalos and presented all collateral blood vessels as mentioned in the previous literature. The study further revealed that the cranial nerve roots were closely related to the arterial circle of the brain and could be used as indicators for differentiating various branches of the arterial circle of the brain. In addition to the usual variations of the arterial circle of the brain, a bihemispheric rostral cerebral artery along with an aplastic rostral cerebral artery were reported for the first time. The deviant behaviour of the rostral cerebral artery forms a baseline to study various clinical conditions of the blood vasculature in the buffalo brain. The rostral choroidal, middle cerebral and the caudal cerebral arteries constantly were emerged as single vessels without any variations. In conclusion, the anatomy of the arterial vasculature of the buffalo brain observed in the present study provided evidence of its morphological resemblance to other species of the Bovini tribe.
Bayesian modelling of effects of prenatal alcohol exposure on child cognition based on data from multiple cohorts
Authors: Dang Khue‐Dung , Ryan Louise M. , Akkaya Hocagil Tugba , Cook Richard J. , Richardson Gale A. , Day Nancy L. , Coles Claire D. , Carmichael Olson Heather , Jacobson Sandra W. , Jacobson Joseph L. 
Published: September 2023

SummaryHigh levels of prenatal alcohol exposure (PAE) result in significant cognitive deficits in children, but the exact nature of the dose‐response relationship is less well understood. To investigate this relationship, data were assembled from six longitudinal birth cohort studies examining the effects of PAE on cognitive outcomes from early school age through adolescence. Structural equation models (SEMs) are a natural approach to consider, because of the way they conceptualise multiple observed outcomes as relating to an underlying latent variable of interest, which can then be modelled as a function of exposure and other predictors of interest. However, conventional SEMs could not be fitted in this context because slightly different outcome measures were used in the six studies. In this paper we propose a multi‐group Bayesian SEM that maps the unobserved cognition variable to a broad range of observed outcomes. The relation between these variables and PAE is then examined while controlling for potential confounders via propensity score adjustment. By examining different possible dose‐response functions, the proposed framework is used to investigate whether there is a threshold PAE level that results in minimal cognitive deficit.
Glomerular microcirculation: Implications for diabetes, preeclampsia, and kidney injury
Authors: Goligorsky Michael S. 
Published: September 2023

AbstractThis review outlines the features of tandem regulation of glomerular microcirculation by autoregulatory mechanisms and intraglomerular redistribution of blood flow. Multiple points of cooperation exist between autoregulatory and distributional mechanisms. Mutual interactions between myogenic and tubuloglomerular feedback (TGF) mechanisms regulating the inflow are briefly discussed. In addition to this, TGF operation involving purinergic, autocoid, and NO signaling affects, however, not only afferent arteriolar tone, but mesangial cell tone as well. The latter reversibly reconfigures the distribution of blood flow between the shorter and longer pathways in the glomerular tuft. I advance a hypothesis that blood flow in these pathways spontaneously alternates, and mesangial cell tonicity serves as a rheostatic shift between them. Furthermore, humoral messengers from macula densa cells, themselves dependent on myogenic mechanisms, fine‐tune the secretion of renin and, subsequently, the local, intrarenal generation of angiotensin II, which, in turn, provides additional vasomotor signaling to glomerular capillaries through changing the tone of mesangial cells. This complex regulatory network may partially explain the phenomenon of renal functional reserve, as well as suggest implications for changes in renal function during pregnancy, early diabetes mellitus, and acute kidney injury.
Distinct functions between ferrous and ferric iron in lung cancer cell growth
Authors: Hinokuma Hironori , Kanamori Yohei , Ikeda Koei , Hao Li , Maruno Masataka , Yamane Taishi , Maeda Ayato , Nita Akihiro , Shimoda Mayuko , Niimura Mayumi , Takeshima Yuki , Li Shuran , Suzuki Makoto , Moroishi Toshiro 
Published: September 2023

AbstractAccumulating evidence suggests an association between iron metabolism and lung cancer progression. In biological systems, iron is present in either reduced (Fe2+; ferrous) or oxidized (Fe3+; ferric) states. However, ferrous and ferric iron exhibit distinct chemical and biological properties, the role of ferrous and ferric iron in lung cancer cell growth has not been clearly distinguished. In this study, we manipulated the balance between cellular ferrous and ferric iron status by inducing gene mutations involving the FBXL5–IRP2 axis, a ubiquitin‐dependent regulatory system for cellular iron homeostasis, and determined its effects on lung cancer cell growth. FBXL5 depletion (ferrous iron accumulation) was found to suppress lung cancer cell growth, whereas IRP2 depletion (ferric iron accumulation) did not suppress such growth, suggesting that ferrous iron but not ferric iron plays a suppressive role in cell growth. Mechanistically, the depletion of FBXL5 impaired the degradation of the cyclin‐dependent kinase inhibitor, p27, resulting in a delay in the cell cycle at the G1/S phase. FBXL5 depletion in lung cancer cells also improved the survival of tumor‐bearing mice. Overall, this study highlights the important function of ferrous iron in cell cycle progression and lung cancer cell growth.
Family homeless shelters as contexts for early childhood development: Shelter resources and staff capacity
Authors: Halverson McKenna M. , Wallace Laura E. , Tebepah Tariere C. , Riccelli Victoria , Bajada Allison , Herbers Janette E. 
Published: September 2023

AbstractFamily homeless shelters are critical contexts in which many young children develop; however, little is known about the developmental appropriateness of these settings, including their resources and the capacity of their staff to effectively meet the needs of the children and families they serve. The current study involves both quantitative and qualitative components to assess aspects of developmental appropriateness of US shelter spaces for children ages birth to 5 years, with an emphasis on staff knowledge, parenting programmes, and play spaces. Participants were 64 staff working in different family homeless shelters representing all 10 Housing and Urban Development regions. Data were collected via semistructured phone interviews. Results indicated that most shelters offered some type of parenting programme (65.5%) and had some developmentally appropriate space for families with young children (87.5%); however, the nature of these spaces and programmes varied considerably, with very few respondents describing use of evidence‐based practices. Findings on knowledge of early child development among shelter staff indicated substantial need for trainings on a range of topics, including typical child development, parent–child relationships, and impacts of trauma on families with young children. Furthermore, we identified a need for better measurement tools to assess knowledge of child development.
Habit training versus habit training with direct visual biofeedback in adults with chronic constipation: A randomized controlled trial
Authors: Norton Christine , Bannister Sybil , Booth Lesley , Brown Steve R. , Cross Samantha , Eldridge Sandra , Emmett Christopher , Grossi Ugo , Jordan Mary , Lacy‐Colson Jon , Mason James , McLaughlin John , Moss‐Morris Rona , Scott S. Mark , Stevens Natasha , Taheri Shiva , Taylor Stuart A. , Yiannakou Yan , Knowles Charles H. 
Published: September 2023

AbstractAimThe aim was to determine whether specialist‐led habit training using Habit Training with Biofeedback (HTBF) is more effective than specialist‐led habit training alone (HT) for chronic constipation and whether outcomes of interventions are improved by stratification to HTBF or HT based on diagnosis (functional defaecation disorder vs. no functional defaecation disorder) by radio‐physiological investigations (INVEST).MethodThis was a parallel three‐arm randomized single‐blinded controlled trial, permitting two randomized comparisons: HTBF versus HT alone; INVEST‐ versus no‐INVEST‐guided intervention. The inclusion criteria were age 18–70 years; attending specialist hospitals in England; self‐reported constipation for >6 months; refractory to basic treatment. The main exclusions were secondary constipation and previous experience of the trial interventions. The primary outcome was the mean change in Patient Assessment of Constipation Quality of Life score at 6 months on intention to treat. The secondary outcomes were validated disease‐specific and psychological questionnaires and cost‐effectiveness (based on EQ‐5D‐5L).ResultsIn all, 182 patients were randomized 3:3:2 (target 384): HT n = 68; HTBF n = 68; INVEST‐guided treatment n = 46. All interventions had similar reductions (improvement) in the primary outcome at 6 months (approximately −0.8 points of a 4‐point scale) with no statistically significant difference between HT and HTBF (−0.03 points; 95% CI −0.33 to 0.27; P = 0.85) or INVEST versus no‐INVEST (0.22; −0.11 to 0.55; P = 0.19). Secondary outcomes showed a benefit for all interventions with no evidence of greater cost‐effectiveness of HTBF or INVEST compared with HT.ConclusionThe results of the study at 6 months were inconclusive. However, with the caveat of under‐recruitment and further attrition at 6 months, a simple, cheaper approach to intervention may be as clinically effective and more cost‐effective than more complex and invasive approaches.
Effects of triclabendazole and its metabolite exposure on the heart‐rate–corrected QT intervals: A randomized, placebo‐ and positive‐controlled thorough QT study in healthy individuals
Authors: Prince William T. , Venishetty Vinay Kumar , Lecot Jean , Shakeri‐Nejad Kasra , Gray Cathy , Taylor Amanda , Iyer Ganesh R. , Zack Julia 
Published: September 2023

AbstractTriclabendazole is an effective and well‐tolerated treatment for human fascioliasis. A placebo‐ and positive‐controlled, four‐sequence by four‐period crossover study was conducted in 45 healthy participants to assess the effect of therapeutic (10 mg/kg twice daily [b.i.d.] for 1 day) and supratherapeutic (10 mg/kg b.i.d. for 3 days) oral doses of triclabendazole on corrected QT (QTc) interval prolongation. Moxifloxacin (400 mg, oral) was used as a positive control. The highest mean placebo‐corrected change from baseline in QTcF (ΔΔQTcF) on day 4 with triclabendazole was 9.2 at therapeutic dose ms and 21.7 ms at supratherapeutic dose, at 4 h postdose. The upper limit of the two‐sided 90% confidence interval exceeded 10 ms across all timepoints, except at predose timepoint on day 4 in the therapeutic group indicating that an effect of triclabendazole on cardiac repolarization could not be excluded. However, triclabendazole had no clinically significant effects on heart rate and cardiac conduction at the studied doses. In the moxifloxacin group, the mean ΔΔQTcF peak value was 13.7 ms at 3 h on day 4. The assay sensitivity was confirmed. Maximum plasma concentration of triclabendazole, sulfoxide metabolite, and sulfone metabolite occurred at ~3‐, 4‐, and 6‐h postdose, respectively. No deaths, serious adverse events, study discontinuations due to treatment‐emergent adverse events, or clinically relevant abnormalities in laboratory evaluations and vital sign values were observed. This study showed that triclabendazole had no clinically relevant effects on heart rate and cardiac conduction; however, an effect on cardiac repolarization (ΔΔQTcF >10 ms) could not be excluded.