bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing Mining: New Environmental Contracts In Light Of Loss, Inequality, and Climate Change
Authors: Lessmeier Katie 
Published: January 2025

Abstract
Mining, particularly for copper, has long been considered ‘Chile’s national salary.’ Similarly, hopes for national wealth have long coexisted in tension with the environmental harms that mining causes—water use, toxic waste, landscape destruction, and more. This tension has become acute as mining has intensified and its impacts amplified with climate change. The CC grappled with these competing goals in its efforts to redefine the conditions for mining in Chile, aiming to create a framework better able to take mining into a future rocked by climate change. This chapter highlights the importance of constitutional reform for the governance of extractive operations, in Chile and elsewhere, as well as the implications of the CC Statute of Minerals (Articles 145–147) for how to assess and understand the global expansion of ‘green’ energy initiatives.
Re-thinking Property and Pollution: Conserving the Night Sky as Natural Commons
Authors: Millet Isabella 
Published: January 2025

Abstract
Chile’s 1980 Constitution stands out globally for instituting strong private property rights over many things—including water, mineral concessions, education, and health services—with the result that access to basic human needs is at the mercy of the market, often leading to higher costs for low-income people and increasing inequality. A major objective of the CC was to address or reverse these dynamics by introducing novel notions of property such as common goods—as distinct from public goods—and using the concept of ‘natural commons’ within environmental governance. This chapter explores the natural commons through a novel lens—the movement to protect dark night skies—and acknowledges long histories in Chile of astronomy research conducted by Indigenous peoples, community organizations, and university scientists. Studying two constitutional articles in particular, this chapter examines the possibilities they open up for reimagining nature, knowledge, research relations, and the critical framing of environmental justice issues.
The tomato gene Ty-6, encoding DNA polymerase delta subunit 1, confers broad resistance to Geminiviruses
Authors: Shen Xuexue , Gill Upinder , Arens Marjon , Yan Zhe , Bai Yuling , Hutton Samuel F. , Wolters Anne-Marie A. 
Published: January 2025

Abstract

Key message
The tomato Ty-6 gene conferring resistance against begomoviruses has been cloned and shown to be a variant of DNA polymerase delta subunit 1.

Abstract

Ty-6 is a major resistance gene of tomato that provides resistance against monopartite and bipartite begomoviruses. The locus was previously mapped on chromosome 10, and in this study, we fine-mapped Ty-6 to a region of 47 kb, including four annotated candidate genes. Via whole-genome resequencing of Ty-6 breeding lines and several susceptible breeding lines, the polymorphisms in gene sequences were discovered and gene-associated markers were developed for marker-assistant breeding. Further, virus-induced gene silencing and candidate gene overexpressing in susceptible tomatoes revealed that Ty-6-mediated resistance is controlled by Solyc10g081250, encoding the DNA polymerase delta subunit 1, SlPOLD1. The single nucleotide polymorphism of Ty-6 results in an amino acid change that might influence the fidelity of virus DNA replication.
Association of nutritional status indices with gastrointestinal symptoms in systemic sclerosis: a cross-sectional study
Authors: Öz Nuran , Gezer Halise Hande , Karabulut Yusuf , Duruöz Mehmet Tuncay 
Published: January 2025

Abstract
Gastrointestinal (GI) involvement is highly prevalent in systemic sclerosis (SSc) and significantly affects patient quality of life and clinical outcomes. This study investigates the potential of undernutrition scores, namely the Control of Nutritional Status (CONUT) score and the Prognostic Nutrition Index (PNI), in predicting GI involvement in patients with SSc. A total of 82 patients diagnosed with SSc were enrolled in this cross-sectional study. Participants were evaluated using the UCLA Scleroderma Clinical Research Consortium Gastrointestinal Tract 2.0 (UCLA GIT 2.0) tool, which assesses the severity of GI symptoms and their impact on health-related quality of life. Malnutrition was assessed using CONUT and PNI scores derived from routine laboratory parameters. The correlation between these malnutrition indices and the UCLA GIT 2.0 scores was analyzed to determine the predictive value of malnutrition in GI involvement. The study found that patients with higher CONUT scores, indicating malnutrition, had significantly higher total UCLA GIT 2.0 scores. A moderate positive correlation was observed between CONUT scores and total UCLA GIT 2.0 scores (r =.539; p <.01), while a negative correlation was found between CONUT scores and PNI (r = −.513; p <.01). These findings suggest that malnutrition, as measured by CONUT and PNI, is associated with greater GI involvement in SSc. This study shows that malnutrition indices such as CONUT and PNI in SSc patients, together with the UCLA GIT 2.0 score, may serve as usefull predictors of GI involvment in routine clinical practice.
A machine learning approach for estimating Eastern Asian origins from massive screening of Y chromosomal short tandem repeats polymorphisms
Authors: You Haeun , Lee Soong Deok , Cho Sohee 
Published: January 2025

Abstract
Inferring the ancestral origin of DNA evidence recovered from crime scenes is crucial in forensic investigations, especially in the absence of a direct suspect match. Ancestry informative markers (AIMs) have been widely researched and commercially developed into panels targeting multiple continental regions. However, existing forensic ancestry inference panels typically group East Asian individuals into a homogenous category without further differentiation. In this study, we screened Y chromosomal short tandem repeat (Y-STR) haplotypes from 10,154 Asian individuals to explore their genetic structure and generate an ancestry inference tool through a machine learning (ML) approach. Our research identified distinct genetic separations between East Asians and their neighboring Southwest Asians, with tendencies of northern and southern differentiation observed within East Asian populations. All machine learning models developed in this study demonstrated high accuracy, with the Asian classification model achieving an optimal performance of 82.92% and the East Asian classification model reaching 84.98% accuracy. This work not only deepens the understanding of genetic substructures within Asian populations but also showcases the potential of ML in forensic ancestry inference using extensive Y-STR data. By employing computational methods to analyze intricate genetic datasets, we can enhance the resolution of ancestry in forensic contexts involving Asian populations.
The effectiveness of balneotherapy on pain, walking, and function in patients with diabetic neuropathy: a prospective observational study
Authors: Dogaru Gabriela , Ciubean Alina Deniza , Marinescu Luminița , Pop Bianca-Maria , Pașca Gabriel-Sorin , Ciumărnean Lorena 
Published: January 2025

Abstract
The treatment of type 2 diabetes patients with diabetic neuropathy using pharmacological and non-pharmacological measures remains a current topic. The aim of this study is to evaluate the effect of comprehensive medical rehabilitation programs that include natural therapeutic factors (carbonated natural mineral water) on pain, gait, and functional status in these patients. Fifty patients diagnosed with type 2 diabetes and diabetic neuropathy in the lower limbs participated in the study. Half of them (DZ-PT) underwent treatment consisting of physical exercises, physiotherapy, and terrain cure, while the other half (DZ-CMW) received the same treatment plus baths with carbonated natural mineral water. Patients were evaluated using assessment scales for pain Visual Analogue Scale (VAS), the 10-meter walking test (W10m), lower limb muscle strength (FM), Functional Independence Measure (FIM), and Neuropathy Disability Score (NDS). The results showed a statistically significant reduction in pain assessed by VAS at the end of the treatment, persisting for three months (p-values < 0.001 between the two groups), with a greater reduction in the DZ-CMW group. Similarly, a significant improvement in gait, evaluated by W10m, was found both at the end of the treatment and at 3 months after its completion, with greater improvement in the DZ-CMW group. In conclusion, patients with type 2 diabetes with diabetic neuropathy can benefit from comprehensive medical rehabilitation programs periodically, including therapeutic natural factors, at balneoclimacteric resorts, alongside medication, dietary regimen, and physical activity.
The effect of hand and foot exercises on peripheral neuropathy and quality of life in women with breast cancer: a randomized controlled trial
Authors: Uysal Neşe , Ünal Toprak Filiz 
Published: January 2025

Abstract

Purpose
Peripheral neuropathy is one of the most devastating symptoms experienced by the patients. Supportive and holistic care interventions are crucial to help these patients. The aim of this study is to determine the effects of hand and foot exercises on chemotherapy-induced peripheral neuropathy and quality of life in women with breast cancer.

Methods
The sample of this randomized controlled trial study consisted of 79 women with breast cancer who underwent taxane-group chemotherapy in a hospital. The women diagnosed with grade 1 or higher peripheral neuropathy were included in the study. Women were divided into three groups as exercises with a massage ball, exercises with a stress ball, and control group. Hand and foot exercises last for 8 weeks. Data were collected using the Information Form, the Common Terminology Criteria for Adverse Events, and the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire.

Results
The severity of neuropathy decreased significantly in both massage ball and stress ball exercise groups compared to the control group (p < 0.05). The group and time interaction was statistically significant in fatigue, pain, and motor symptoms (p < 0.05).

Conclusion
Women with breast cancer who undergo neurotoxic chemotherapy are thought to alleviate neuropathy symptoms and enhance their quality of life through simple home-based exercises. Nonpharmacological, applicable interventions, such as hand-foot exercises, can be integrated into patient education and care practices during the chemotherapy process.

Trial registration

ClinicalTrails.gov (Registration number: NCT06055088. registered on 01 June 2023).
Anämie – nicht immer Eisenmangel …
Authors: Novak Wolfgang , Boztug Kaan , Kager Leo 
Published: January 2025

ZusammenfassungEisenmangel ist die häufigste Ursache für Anämien im Kindesalter, jedoch können auch zahlreiche andere Pathologien zugrunde liegen. Eine systematische Differenzierung der Ätiologien ist daher von zentraler Bedeutung, um eine präzise Diagnostik zu ermöglichen und eine effektive Therapie zu gewährleisten. Die initiale Klassifikation erfolgt häufig anhand des mittleren Erythrozytenvolumens (MCV), wodurch Anämien in mikrozytäre, normozytäre und makrozytäre Formen unterteilt werden. Eine weitergehende Subklassifizierung berücksichtigt die Retikulozytenzahl (hypo- oder hyperregeneratorisch) sowie den Eisenstatus des Patienten . Insbesondere in der Pädiatrie sind genetisch bedingte Erkrankungen wie die Hämoglobinopathien, die Sphärozytose oder seltene Syndrome wie die Diamond-Blackfan-Anämie wichtige Differenzialdiagnosen. Dieser Artikel soll die Vielfalt der Anämieformen aufzeigen und verdeutlichen, wie essenziell ein strukturiertes diagnostisches Vorgehen ist, um letztlich die richtige Diagnose und Therapie für Betroffene sicherzustellen.
Endovaskuläre Techniken zur Erhaltung der linken Arteria subclavia im Rahmen von TEVAR in Zone 2
Authors: Reutersberg Benedikt , Meuli Lorenz , Menges Anna-Leonie , Zimmermann Alexander 
Published: January 2025

Zusammenfassung
Die thorakale endovaskuläre Aortenreparatur (TEVAR) ist die Standardtherapie für Pathologien im distalen Aortenbogen und der Aorta descendens. In bis zu 50 % der Fälle ist eine Landung in der Ischimaru-Zone 2 notwendig, um eine sichere Abdichtung zu erreichen, wobei die Perfusion der linken A. subclavia (LSA) erhalten bleiben sollte, um Schlaganfälle und Ischämien zu vermeiden. Zur Revaskularisierung der LSA stehen offene chirurgische Verfahren wie der karotidosubklaviale/axilläre Bypass und die LSA-Transposition sowie endovaskuläre Ansätze wie gebranchte (bTEVAR) und fenestrierte Endoprothesen (fTEVAR) zur Verfügung. Endovaskuläre Techniken umfassen „custom-made“ (CMD), Off-the-Shelf- und Physician-modified-Devices (PMD), wobei letztere in Ex- und In-situ-Modifikationen unterteilt werden. Eine weitere Methode ist die Parallelgrafttechnik. Die Wahl der Technik hängt von der Anatomie des Patienten, den technischen Möglichkeiten und der Expertise des Behandlers ab.
bTEVAR-Prothesen sind technisch anspruchsvoll und erfordern oft zusätzliche Manipulationen. fTEVAR benötigen eine engere Lagebeziehung zur Aortenwand und erfordert daher einen größeren Abstand zur Aortenpathologie. CMD-Prothesen bieten höchste Präzision, sind jedoch teuer und nicht immer verfügbar. Off-the-Shelf- und PMD-Prothesen bieten mehr Flexibilität, wobei PMDs spezielle Expertise erfordern. Die Parallelgraft-Technik wird als Bailout-Strategie eingesetzt.
Zukünftige Entwicklungen zielen auf standardisierte, kostengünstigere Lösungen ab, jedoch fehlen noch Langzeitergebnisse. Größere Studien sind notwendig, um die optimale Technik zu bestimmen.
Der Artikel gibt einen Überblick über die aktuellen endovaskulären Debranching-Techniken der LSA und diskutiert deren Vor- und Nachteile.
IntraJ: an on-demand framework for intraprocedural Java code analysis
Authors: Riouak Idriss , Fors Niklas , Hedin Görel , Reichenbach Christoph 
Published: January 2025

Abstract
Static analysis tools play a crucial role in software development by detecting bugs and vulnerabilities. However, running these tools separately from the code editing process often causes developers to switch contexts, which can reduce productivity. Previous work has shown how Reference Attribute Grammars (RAGs) can be used for declarative implementation of competitive tooling for intraprocedural control-flow and dataflow analysis of Java source code, embodied in the tool IntraJ. In this paper, we demonstrate how IntraJ can be leveraged to provide interactive analysis results directly in the editor, similar to compile-time error detection, relying on automatic on-demand evaluation of RAGs. We discuss the architecture of IntraJ, and demonstrate how it can be integrated into the development process in three different ways: in the command line, in an editor integration based on the Language Server Protocol, and in an integration with the debugging tool CodeProber. We showcase the extensibility of IntraJ by illustrating how new client analyzes and language constructs can be added to the framework through RAG specifications. Finally, we evaluate the interactive performance of IntraJ on a set of real-world Java benchmarks, demonstrating that IntraJ can provide interactive feedback to developers, achieving a response time of under 0.1 seconds for most compilation units.
Evaluating the Implementation of Home-Based Sexual Health Care Among Men Who Have Sex with Men: Limburg4zero
Authors: Goense Cornelia Johanna Dorothy , Evers Ymke J. , Manait Jonas , Hoebe Christian J. P. A. , van Loo Inge H. M. , Posthouwer Dirk , Ackens Robin , van Hooren Roland , Theuerzeit Rocxanne , Crutzen Rik , Stutterheim Sarah E. , Dukers-Muijrers Nicole H. T. M. 
Published: January 2025

Abstract
Home-based sexual health care (including self-sampling testing) could reduce barriers to clinic-based testing. This study systematically evaluated the implementation of home-based sexual health care (‘Limburg4Zero’) among men who have sex with men (MSM) in a mixed urban–rural region of the Netherlands. We systematically assessed implementation outcomes (contextual domains, population reached, effectiveness, adoption by health care providers (HCP), implementation fidelity, and maintenance) using the practical, robust implementation and sustainability model. We used a mixed-methods research design that combined survey and in-depth interview data from our priority population (MSM) and implementers with insights from our community advisory board and field notes from monthly meetings with the implementers. Of 1076 requested tests, 906 MSM received a (self-sampling STI/HIV) test kit and sexual health information. Most participants (median age 31) had a university or college degree and had a Western ethnicity. The return rate for laboratory testing was 67%. Home-based care participants more often never tested HIV before (39%) compared to STI clinic attendees (28%). Adoption by HCP was highly acceptable, although perceived pragmatic and technical challenges were experienced. Key elements of the home-based care service were implemented as designed, with co-created adjustments for optimization during the implementation. Maintaining the innovation in the long term was desirable, although future recommendations for efficient continuation should be considered. Implementation of home-based sexual health care has demonstrably increased care accessibility for MSM who had never previously been tested. Therefore, a systematic approach is crucial to foster the impact of home-based sexual health care.
Marital and living status and biological ageing trajectories: a longitudinal cohort study with a 20-year follow-up
Authors: Yin Weiyao , Li Xia , Chen Ruoqing , Zhan Yiqiang , Jylhävä Juulia , Fang Fang , Hägg Sara 
Published: January 2025

Abstract
Biomarkers of ageing (BA) can predict health risks beyond chronological age, but little is known about how marital/living status affects longitudinal changes in BA. We examined the association between marital/living status and BA over time using the-Swedish-Adoption/Twin-Study-of-Aging (SATSA) cohort. Four BAs were analyzed: telomere length (TL) (638 individuals; 1603 measurements), DNAmAge (535 individuals; 1392 measurements), cognition (823 individuals; 3218 measurements), and frailty index (FI) (1828 individuals; 9502 measurements). Individuals were born between 1900 and 1948, and data on marital/living status, BAs, and covariates were collected through nine waves of questionnaires and in-person testing from 1986 to 2014. Mixed linear regression with random effects at twin-pair and individual levels were used to assess BA changes for constant marital/living status. Conditional generalized estimating equation assessed within-individual BA changes for varying marital/living status. Results showed that individuals who were consistently unmarried/non-cohabiting (β = 0.291, 95%CI = 0.189–0.393) or living alone (β = 0.203, 95%CI = 0.090–0.316) were more frail, and experienced accelerated frailty (p-for-interaction with age < 0.001 for marital status; p-for-interaction = 0.002 for living status) and cognitive decline (p-for-interaction < 0.001), compared to those married/cohabiting or living with someone Among individuals whose marital/living status changed, frailty was higher when living alone (β = 0.089, 95%CI = 0.017–0.162) and frailty accelerated when they became unmarried/non-cohabiting or were living alone (p-for-interaction < 0.001). Cognitive decline also accelerated when living alone (p-for-interaction = 0.020). No associations were observed for TL and DNAmAge. In conclusion, being unmarried/non-cohabiting or living alone from mid-to-old age is linked to accelerated cognitive decline and frailty. These findings highlight the potential importance of social support networks and living arrangements for healthy ageing.
Surface Roughness in Stratified Turbulent Ekman Flow
Authors: Kostelecky Jonathan , Ansorge Cedrick 
Published: January 2025

Abstract
The interplay of surface roughness and stable stratification is investigated by direct numerical simulation of Ekman flow. Our setup is well within the turbulent regime, reaching a friction Reynolds number of

$$Re_\tau \approx 2700$$

R

e
τ

≈
2700

. Further, we reach the verge of the fully rough regime under neutral conditions with a non-dimensional obstacle height

$$H^+\approx 40$$

H
+

≈
40

, corresponding to a z-nought parameter in viscous units

$$z_0^+\approx 2$$

z
0
+

≈
2

. Stability is imposed via a gradual decrease of surface buoyancy from neutral (no stratification) to very strong stratification. The reduced Reynolds number (

$$Re_\tau $$

R

e
τ

) in comparison to atmospheric problems warrants consideration of viscous effects on our results, and we demonstrate a correction method that consistently incorporates viscous effects, thus reducing the spread of data from our numerical results. The weakly stable regime is maintained at higher stability due to efficient production of turbulence kinetic energy which counteracts buoyant restoring forces in the presence of roughness. When scaled according to Monin–Obukhov similarity theory (MOST) our results for weak stability compares excellent to known formulations based on atmospheric observations. The coefficients of the stability correction functions for momentum and heat are estimated as

$$\beta _\textrm{m}=3.45$$

β
m

=
3.45

,

$$\beta _\textrm{h}=5.21$$

β
h

=
5.21

respectively, and we observe a slight but significant increase of the turbulent Prandtl number with stability. In the very stable regime, global flow properties (e.g. friction velocity, Obukhov length) oscillate with a decaying amplitude and global intermittency, i.e. the co-occurrence of turbulent/laminar fluid at large scale, is observed in the presence of roughness. In such very stable conditions, a strong veering of the surface wind with respect to the large-scale forcing (

$$<90^\circ $$

<

90
∘

) is observed.
Effect of magnetic field strength and segmentation variability on the reproducibility and repeatability of radiomic texture features in cardiovascular magnetic resonance parametric mapping
Authors: Yamlome Pascal , Jordan Jennifer H. 
Published: January 2025

Abstract
Our study aims to assess the robustness of myocardial radiomic texture features (RTF) to segmentation variability and variations across scanners with different field strengths, addressing concerns about reliability in clinical practices. We conducted a retrospective analysis on 45 pairs of CMR T1 maps from 15 healthy volunteers using 1.5 T and 3 T Siemens scanners. Manual left ventricular myocardium segmentation and a deep learning-based model with Monte Carlo Dropout generated masks with different levels of variability and 1023 RTFs extracted from each region of interest (ROI). Reproducibility: the extent to which RTFs extracted from 1.5 T and 3 T images are consistent, and repeatability: the extent to which RTFs extracted from multiple segmentation runs at the same field strength agree with each other, were measured by the intraclass correlation coefficient (ICC). We categorized ICC values as excellent, good, moderate, and poor. We reported the proportion of RTFs that fell in each category. The proportion of RTFs with excellent repeatability decreased as the proportion of ROI pixels in congruence across segmentation runs decreased. Up to 31% of RTFs showed excellent repeatability, while 35% showed good repeatability across segmentation runs from the manually generated masks. Across scanners (i.e., 1.5 T vs 3 T), only 7% exhibited good reproducibility. While our results demonstrate RTF sensitivity to differences in field strength and segmentation variability, we identified certain preprocessing filters and feature classes that are less sensitive to these variations and, as such, may be good candidates for imaging biomarkers or building machine-learning models.