bluuebunny/crossref_metadata_2025_split huggingface dataset:
The family structural and socioeconomic characteristics of the family well‐being of Hong Kong people
Authors: Xia Lily L. L. , Wong Mooly M. C. , Ma Joyce L. C. , Wan Po‐san 
Published: August 2023

AbstractThis study investigated the family well‐being of Hong Kong people through a randomized telephone survey of 2008 adults, using a standardized six‐domain index developed specifically for this population. Multiple regression analyses were conducted to examine the heterogeneity of family well‐being according to demographic, family structural, and socioeconomic characteristics. The results showed significant gender and age differences in people's perception of family well‐being. Education, family income, and hiring a domestic helper were also associated with higher family wellbeing index scores, while the impacts of economic activity status, family size, and caring for young children were found to be insignificant. The impact of marital status was somewhat complicated. This article discusses variations observed in the influence of the set of demographic, family structural, and socioeconomic characteristics on overall and domain‐specific family well‐being. Implications for future studies and for social policy formulation and social work practice are suggested.
The Political Privacy Dilemma: Private Lives and Public Office
Authors: Devine John William 
Published: August 2023

ABSTRACTShould political leaders have a right to privacy? Incursions by new and traditional media into the private lives of political leaders are commonplace. Are such incursions ethically justifiable? Prima facie, the question of ‘political privacy’ seems to involve a conflict between a politician's self‐interest in retaining a protected private realm and citizens' public interest in having access to information about their representative's private life. Indeed, this is the structure that the debate has typically assumed. I challenge this orthodox view by demonstrating that there is a public interest in political privacy grounded in the relationship between privacy and political judgement. I argue that the political privacy debate should be recast to recognise this conflict between two different strands of the public interest. This conflict presents a dilemma for democratic theory: in providing voters with private information relevant to the evaluation of political leaders' suitability for office and performance within it, we threaten to undermine the conditions necessary to attract candidates of judgement and for political leaders to judge well once in office.
Process standardization of infrared assisted pulsed microwave baked biscuits and its comparison with conventionally baked biscuits
Authors: Gond Priya , Lohani Umesh Chandra , Shahi Navin Chandra , Aman Junaid 
Published: August 2023

AbstractThe present research work was undertaken for process standardization of infrared (IR) and pulsed microwave (MW) assisted baking of biscuits with respect to physiochemical properties in order to reduce process time. Variables were IR baking temperature, IR baking time, MW baking power along with pulsed ON time. However, pulsed OFF time was kept constant at 15 s with three number of cycles for baking. The optimize value for maximum desirability of developed biscuits were 210°C IR baking temperature, 184.2 s IR baking time, 960 W MW baking power and 20 s MW baking ON time resulted in IR‐MW biscuits with 15.1 color difference, 5.96% spread ratio, 3.86% wb moisture content, 159.2 N hardness, 0.26 cohesiveness, 0.32 springiness, 054% free fatty acid, and 7.42 sensory acceptability. Significant (p < 0.05) effect of process parameters was found on all responses for developed wheat flour based biscuits. Biscuits developed at optimum conditions of IR assisted MW baking were compared with conventionally baked one with respect to spread ratio (%), hardness (N), and microscopic structure. IR assisted MW baked biscuits were found superior in quality and took 77% lesser time than conventional baking.Practical ApplicationsThis study results that energy conservation and baking time can be reduced by using infrared assisted pulsed microwave baking technique. Minimizing the processing time, minimize the exposure of food to heat leads to less nutrient loss. This newer food‐processing technology has the potential to reduce the baking time up to 77% which can be beneficial for the baking industry along with reduction in energy conservation, it is in favor at economical level as well. In the combined infrared microwave heating method, microwave heating is used to accelerate the entire baking process, while infrared heating is utilized to promote browning and crisping reactions on the product surfaces.
The impact of vegetarian diet on sperm quality, sex hormone levels and fertility: a systematic review and meta‐analysis
Authors: Samimisedeh Parham , Afshar Elmira Jafari , Ejtahed Hanieh‐Sadat , Qorbani Mostafa 
Published: August 2023

AbstractBackgroundAn increasing number of people have adhered to a vegetarian diet for several years. Nowadays, the favourable effect of this dietary pattern on metabolic diseases is well established, but its impact on fertility and reproductive health as a serious health concern is not clear yet.Therefore, we aim to summarise existing evidence regarding the possible association between a vegetarian diet and fertility as measured by key indicators such as sperm quality and sex hormone levels.MethodsWe systematically searched online databases, including PubMed, ISI, Scopus and Google Scholar, up to 1 December 2022 using relevant keywords. We included observational studies that compared semen quality, sex hormone levels and infertility in people who adhered to a vegetarian diet versus an omnivore diet. Heterogeneity between studies was assessed using I2 and Q tests. Standardised mean differences (SMD) using a random/fixed model were calculated to assess outcomes between vegetarians and omnivores in included articles.ResultsFinally, out of 972 documents that were retrieved, 20 articles met our inclusion criteria, and 16 were eligible for quantitative synthesis. Results of meta‐analyses showed that there were no significant differences between vegetarians and omnivores in terms of semen quality parameters, including total sperm count, total and progressive sperm motility, sperm morphology and sperm concentration. Seven studies on female sex hormone profiles were eligible for meta‐analysis. The only significant difference was the lower level of plasma oestrone in vegetarians (pooled SMD: −0.56; 95% confidence interval [CI]: −1.08, −0.05; p‐value = 0.03) compared to omnivores. Furthermore, our meta‐analysis revealed significantly higher sex‐hormone‐binding globulin levels in vegetarian men than in omnivores (pooled SMD: 0.52; 95% CI: 0.18, 0.86; p‐value = 0.002).ConclusionDespite the numerous health benefits of a vegetarian diet, our review suggested that there were no conclusive positive or negative associations between vegetarian diet and semen quality, sex hormone levels and infertility. Further studies are recommended to better understand vegetarian dietary pattern effect on infertility and reproductive health.
Clinical Outcomes of Isobar TTL System with Isthmic Bone Grafting and Pedicle Screw‐Vertebral Plate Hook with Direct Repair of Defect for Lumbar Spondylolysis: A Matched‐Pair Case Control Study
Authors: Li Qiujiang , Hu Bowen , Zhang Zhuang , Kong Qingquan , Gong Quan , Liu Limin , Yang Huiliang , Wang Lei , Song Yueming 
Published: August 2023

ObjectiveAlthough direct isthmic repair, such as PSVPH, did not affect the mobility of the fixed segment and adjacent segment, it has a relatively low rate of isthmic fusion compared with conventional fusion. The Isobar TTL dynamic internal fixation system has been widely used in clinical practice and has achieved satisfactory clinical results. However, the use of the Isobar TTL system in combination with direct isthmic repair for lumbar spondylolysis has rarely been reported. The aim of this study was to compare the clinical and radiologic outcomes between patients who underwent Isobar TTL system and PSVPH with direct repair of defect for lumbar spondylolysis.MethodsStepwise propensity score matching (PSM) for age and sex were performed to keep comparable clinical data between groups in this retrospective and matched‐pair case control study. A total of 50 patients diagnosed with lumbar spondylolysis underwent surgical implantation of the Isobar TTL group (n = 25) or PSVPH group (n = 25) from June 2009 to June 2016. Clinical outcomes were assessed using the Oswestry disability index (ODI), and visual analog score (VAS). Radiographic evaluations included range of motion (ROM) and the disc heights of stabilized segment and adjacent segment, adjacent segment degeneration (ASD) and bony fusion. Three‐dimensional reconstruction of lumbar CT scan was obtained to evaluate bone fusion of the isthmic at final follow‐up. The independent Student's t test and chi‐square test were applied to compare the differences between groups.ResultsA total of 25 patients from TTL group were matched to 25 patients in PSVPH group for age, sex, body mass index (BMI), defect side, spondylolisthesis meyerding, and follow‐up duration. The intervertebral space height (IH) of stabilized segment at postoperative 1 week and final follow‐up in the TTL group was higher than those in the PSVPH group, respectively (P = 0.030; P = 0.013). The ROM of stabilized segment at final follow‐up in the TTL group was significantly lower than that in the PSVPH group (P < 0.001). The bony fusion rate at the final follow‐up was 88.0% (22/25 cages) in the TTL group and 80.0% (20/25 cages) in the PSVPH group. The ODI score at final follow‐up in the TTL group was significantly lower than that in the PSVPH group (P = 0.007).ConclusionOverall, our data suggest that the Isobar TTL system outcomes are comparable to those in the PSVPH, with a similar high bony fusion rate as PSVPH, especially its wider indications as a new surgery.
Micro Electromechanical System Navigation Assists Femoral Extramedullary Alignment Osteotomy in Total Knee Arthroplasty: A Single‐Blind Randomizing Study
Authors: He Mingjiang , Zhang Hongmei , Hu Peiyan , Jing Lin , Shan Pengcheng 
Published: August 2023

ObjectiveA micro‐electromechanical system (MEMS) was developed based on spatial alignment and navigation technology to assist femoral extramedullary alignment osteotomy (FEAO) in total knee arthroplasty (TKA). The system can locate and adjust the femoral distal condylar osteotomy (FDCO) to obtain a better femoral prosthesis placement. It is a portable navigation device and provides an innovative approach for FDCO.MethodsSixty patients who suffered from severe knee osteoarthritis who underwent unilateral TKA from May 14, 2021 to May 30, 2022 were randomly divided into a MEMS‐FEAO group and a conventional femoral intramedullary alignment osteotomy (FIAO) group, with 30 cases in each group for a controlled retrospective study. The hip‐knee‐ankle angle (HKAA) of the lower limb was measured before and after surgery, the femoral valgus angle (FVA) was measured preoperatively, and the femoral prosthesis valgus angle (FPVA) and the femoral prosthesis flexion angle (FPFA) were measured postoperatively following computed tomography imaging protocols. Measurement data is statistically described as mean ± standard deviation c. The count data is described by frequency (constituent ratio) using the rank sum test.ResultA total of 6.7% (2/30) of FEAO compared to 20.0% (6/30) of FIAO cases were postoperative deviations where the HKAA exceeded ±3° of neutral alignment (p < 0.05). The postoperative HKAA was 178.74° ± 1.56° versus 176.64° ± 3.39° (p < 0.05), the HKAA deviation was 1.25° ± 1.56° versus 3.36° ± 3.40° (p < 0.05), and the FPFA was 4.85° ± 2.46° versus 6.60° ± 1.86°(p < 0.05). Therefore, the differences were all statistically significant between the two groups. However, the FPVA was −0.59° ± 2.73° versus −0.80° ± 2.85° (p > 0.05), and there was no statistical significance between the two groups.ConclusionThe MEMS‐FEAO system can improve the accurate alignment and can be utilized as a locator to obtain the best femoral prosthesis placement in TKA and significantly reduce the rate of poor force line of the lower limb.
Comparison between clinical evaluations and laboratory findings and the impact of biofilm on antimicrobial susceptibility in vitro in canine otitis externa
Authors: Luciani Luca , Stefanetti Valentina , Rampacci Elisa , Gobbi Pietro , Valentini Laura , Capuozzo Raffaella , Passamonti Fabrizio 
Published: August 2023

AbstractBackgroundIn canine otitis externa (OE), biofilm‐producing bacteria are frequently present but biofilm may be underdiagnosed clinically.Hypothesis/ObjectivesThe study aimed to investigate an association between clinical and cytological findings with bacteriological data from dogs with OE, to establish, through Environmental Scanning Electron Microscope (ESEM) examination, whether the presence of biofilm in vivo can be predicted and to evaluate the impact of biofilm on antimicrobial susceptibility tests.Materials and MethodsFifty‐six dogs showing clinical signs of OE were enrolled. One cotton swab each was collected for ESEM, bacterial culture and susceptibility testing and for cytology. Staphylococcus pseudintermedius (n = 42, 48.8%) and Pseudomonas aeruginosa (n = 26, 30.2%) were tested for their ability to form biofilm. Minimum Inhibitory Concentrations (MIC), Minimal Biofilm Inhibitory Concentrations (MBIC) and Minimal Biofilm Eradication Concentrations (MBEC) towards enrofloxacin, gentamicin, polymyxin B and rifampicin were determined.ResultsPseudomonas aeruginosa was positively associated with the biofilm clinical evaluation (p < 0.01) and neutrophils (p < 0.05), nuclear streaks (p < 0.01) and rods bacteria (p < 0.01) on cytology. S. pseudintermedius was associated with a low presence of neutrophils. There was a statistical correlation between clinical and cytological biofilm presence (p ≤ 0.01), but none with the biofilm production assay nor ESEM biofilm detection. No differences were found comparing the results of MIC and MBIC. MBEC results showed higher values than MIC and MBIC for all antimicrobials tested (p ≤ 0.001).Conclusions and Clinical RelevanceBiofilm presence in OE was often underdiagnosed. Even if there is no specific clinical or cytological pattern related to biofilm, its presence should always be suspected.
LIDAR for Investigation of the Martian Atmosphere from the Surface
Authors: Lipatov A. N. , Lyash A. N. , Ekonomov A. P. , Makarov V. S. , Lesnykh V. A. , Goretov V. A. , Zakharkin G. V. , Khlyustova L. I. , Antonenko S. A. , Rodionov D. S. , Korablev O. I. 
Published: August 2023

Abstract
The lidar device as part of the meteorological complex of the ExoMars-2022 landing platform is designed to study Martian aerosol, the planetary boundary layer, and small-scale atmospheric turbulence. A miniature lidar based on a pulsed semiconductor laser and an avalanche photodiode in the photon counting mode will make it possible to obtain aerosol backscattering profiles along a vertical path from 10 to 1500 m during the day and from 15 to 10 000 m at night. In the passive mode, the sky brightness is measured in a narrow spectral range and in a narrow solid angle with a frequency of up to hundreds of hertz. The measured fluctuations can provide information about the turbulence of the daytime atmosphere and its relation to dust activity. In the paper we considered the scientific tasks of the experiment, the program of measurements on the surface of Mars and described in detail the components of the equipment and the features of their work.
Bursting Tumor Bubbles to Improve CAR T-cell Therapy
Authors: Ortiz-Espinosa Sergio , Srivastava Shivani 
Published: August 2023

AbstractChimeric antigen receptor (CAR) T cells have had dramatic success in B-cell malignancies, but this efficacy has not yet translated to more common solid tumors. In this issue of Cancer Research, Zhong and colleagues demonstrated that tumor-derived small extracellular vesicles (sEV) contain CAR target antigens like mesothelin, enabling them to preferentially interact with and suppress the activity of CAR T cells in vivo. PD-L1 in tumor-derived sEVs increased upon CAR T-cell infusion and induced PD-L1–dependent suppression of CAR T cells that could be completely reversed by PD-L1 blockade. Strategies to inhibit sEV secretion, via genetic manipulation of tumor cells or pharmacologic inhibition, significantly improved CAR T-cell accumulation, function, and antitumor activity in vivo, suggesting that therapeutic targeting of sEV secretion could be a promising new approach to improving the efficacy of CAR T-cell therapy.See related article by Zhong et al., p. 2790
Abstract A013: Tumor-specific immunity generated by a personalized neoantigen vaccination incorporating locally delivered ipilimumab in renal cell carcinoma
Authors: Braun David A. , Keskin Derin B. , Shukla Sachet A. , McGregor Bradley A. , Schindler Nicholas R. , Blass Eryn , Klaeger Susan , Pomerance Lucas , Sarkizova Siranush , Li Shuqiang , Southard Jackson , Moranzoni Giorgia , Pedersen Christina B. , Liu Yiwen , Chang Steven L. , Hirsch Michelle S. , LeBoeuf Nicole R. , Mossanen Matthew , Chea Vipheaviny , Carulli Isabel , Olive Oriol , Mehndiratta Ambica , Greenslade Haley , Oliveira Giacomo , Iorgulescu J. Bryan , Signoretti Sabina , Aster Jon C. , Elagina Liudmila , Leshchiner Ignaty , Getz Gad , Harden Maegan , Gabriel Stacey , Olsen Lars R. , Neuberg Donna S. , Fritsch Edward F. , Hacohen Nir , Livak Kenneth J. , Carr Steven , Ott Patrick A. , Wu Catherine J. , Choueiri Toni K. 
Published: August 2023

Abstract
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR015) of the Conference Program/Proceedings.
Citation Format: David A. Braun, Derin B. Keskin, Sachet A. Shukla, Bradley A. McGregor, Nicholas R. Schindler, Eryn Blass, Susan Klaeger, Lucas Pomerance, Siranush Sarkizova, Shuqiang Li, Jackson Southard, Giorgia Moranzoni, Christina B. Pedersen, Yiwen Liu, Steven L. Chang, Michelle S. Hirsch, Nicole R. LeBoeuf, Matthew Mossanen, Vipheaviny Chea, Isabel Carulli, Oriol Olive, Ambica Mehndiratta, Haley Greenslade, Giacomo Oliveira, J. Bryan Iorgulescu, Sabina Signoretti, Jon C. Aster, Liudmila Elagina, Ignaty Leshchiner, Gad Getz, Maegan Harden, Stacey Gabriel, Lars R. Olsen, Donna S. Neuberg, Edward F. Fritsch, Nir Hacohen, Kenneth J. Livak, Steven Carr, Patrick A. Ott, Catherine J. Wu, Toni K. Choueiri. Tumor-specific immunity generated by a personalized neoantigen vaccination incorporating locally delivered ipilimumab in renal cell carcinoma [abstract]. In: Proceedings of the AACR Special Conference: Advances in Kidney Cancer Research; 2023 Jun 24-27; Austin, Texas. Philadelphia (PA): AACR; Cancer Res 2023;83(16 Suppl):Abstract nr A013.
Abstract A014: Modeling recurrent chromosomal alterations in renal cell carcinoma evolution
Authors: Dahiya Rashmi , Ly Peter 
Published: August 2023

Abstract
The loss of one copy of chromosome 3p represents an early truncal genetic event in the majority of clear cell renal cell carcinoma (ccRCC) tumors. Chromosome 3p loss can be initiated by chromothripsis, a process in which mis-segregated chromosomes entrapped within abnormal nuclear structures called micronuclei become pulverized into small genomic fragments. These fragments are then re-stitched together to form complex rearrangements that are accompanied by extensive segmental deletions that inactivate critical tumor suppressor genes located on chromosome 3p. Despite being a driver of ccRCC development, the mechanism(s) that initiate chromosome 3p chromothripsis followed by pressures that select for specific rearrangement patterns are poorly understood. To recapitulate early genetic events arising throughout ccRCC evolution, here we developed chromosome 3p-specific micronuclei models in non-transformed human renal proximal tubule epithelial cells (RPTECs) to interrogate recurrent patterns of chromosomal alterations that promote renal cell tumorigenesis. To do so, we used CRISPR/Cas9 to induce a DNA double-strand break on chromosome 3p, which generates chromosome 3p-specific micronuclei when the acentric arm is left unrepaired into the subsequent mitosis. DNA fluorescence in situ hybridization revealed that mis-segregation of chromosome 3p into micronuclei induces chromosome pulverization and rearrangements. Notably, these alterations are sufficient to provide a selective advantage by enabling anchorage-independent growth in vitro. Cytogenetic characterization of partially transformed RPTECs revealed enrichment of chromosome 3p rearrangements, which were gradually lost upon propagation as conventional monolayer cultures. These results provide mechanistic insight into the origins of chromosome 3p alterations in ccRCC and further highlight the role of selection pressure in shaping genome evolution.
Citation Format: Rashmi Dahiya, Peter Ly. Modeling recurrent chromosomal alterations in renal cell carcinoma evolution [abstract]. In: Proceedings of the AACR Special Conference: Advances in Kidney Cancer Research; 2023 Jun 24-27; Austin, Texas. Philadelphia (PA): AACR; Cancer Res 2023;83(16 Suppl):Abstract nr A014.
Abstract A024: Development of potent and selective nicotinamide N-methyltransferase inhibitors for kidney cancer
Authors: Huang Rong , Iyamu Iredia 
Published: August 2023

Abstract
Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that regulates energy balance and methylation potential through the methylation of nicotinamide using S-adenosylmethionine (SAM) as the cofactor. NNMT has emerged as a novel target for both primary and metastatic ccRCC, as its high expression in ccRCC tumor tissues is linked with low survival. Meanwhile, NNMT depletion or inhibition efficiently suppresses the growth and metastasis of ccRCC in cellular and animal studies. Here, we report rational design and synthesize cell-potent and selective NNMT inhibitors with cellular IC50 values of 140 nM, representing the most cell-potent inhibitors to date. Furthermore, our NNMT inhibitors suppress renal cancer 786O and Caki-1 cell growth with a GI50 value of 9.3 and 7.3 µM, respectively. Moreover, our NNMT inhibitors reduced the migration of renal cancer cells through wound healing assay. In summary, our inhibitors would serve as valuable chemical probes to investigate the catalytical function of NNMT and evaluate the therapeutic potential of NNMT for kidney cancer.
Citation Format: Rong Huang, Iredia Iyamu. Development of potent and selective nicotinamide N-methyltransferase inhibitors for kidney cancer [abstract]. In: Proceedings of the AACR Special Conference: Advances in Kidney Cancer Research; 2023 Jun 24-27; Austin, Texas. Philadelphia (PA): AACR; Cancer Res 2023;83(16 Suppl):Abstract nr A024.