bluuebunny/crossref_metadata_2025_split huggingface dataset:
Access to Public Documents and Its Restrictions: a Reflection from the Perspectives of Brazil and Sweden
Authors: Berthier Fernanda Magni 
Published: September 2023

Abstract
The access to public documents is currently perceived as a human right among democratic nations worldwide. While Sweden has a long background of transparency in the core of the government, in Brazil the regulations concerning this matter are very recent. This article compares Swedish and Brazilian law regarding the right to information and its restrictions, particularly when in conflict with privacy and data protection. As a result of the utilization of objective criteria, the Brazilian regulation is considered better, mainly because it has a broader scope and provides for more promotional measures than the Swedish regulation. However, when analyzing the quality of the implementation of the regulations, it is suggested that in both jurisdictions there is still room for improvements in order to have a better balance between openness and secrecy.
Using the Orthogonal Conditional Nonlinear Optimal Perturbations Approach to Address the Uncertainties of Tropical Cyclone Track Forecasts Generated by the WRF Model
Authors: Zhang Han , Duan Wansuo , Zhang Yichi 
Published: September 2023

Abstract
The orthogonal conditional nonlinear optimal perturbations (O-CNOPs) approach for measuring initial uncertainties is applied to the Weather Research and Forecasting (WRF) Model to provide skillful forecasts of tropical cyclone (TC) tracks. The hindcasts for 10 TCs selected from 2005 to 2020 show that the ensembles generated by the O-CNOPs have a greater probability of capturing the true TC tracks, and the corresponding ensemble forecasts significantly outperform the forecasts made by the singular vectors, bred vectors, and random perturbations in terms of both deterministic and probabilistic skills. In particular, for two unusual TCs, Megi (2010) and Tembin (2012), the ensembles generated by the O-CNOPs successfully reproduce the sharp northward-turning track in the former and the counterclockwise loop track in the latter, while the ensembles generated by the other methods fail to do so. Moreover, additional attempts are performed on the real-time forecasts of TCs In-Fa (2021) and Hinnamnor (2022), and it is shown that O-CNOPs are very useful for improving the accuracy of real-time TC track forecasts. Therefore, O-CNOPs, together with the WRF Model, could provide a new platform for the ensemble forecasting of TC tracks with much higher skill.
Radiofrequency ablation of atrial fibrillation: A 14 years’ experience at a tertiary care center in Thailand
Authors: Tokavanich Nithi , Leelapatana Pattranee , Chokesuwattanaskul Ronpichai , Prechawat Somchai , Rungpradubvong Voravut 
Published: September 2023

Background The result of atrial fibrillation (AF) ablation varies across centers. Most data are derived from the Western world, while data from Southeast Asian countries are lacking. We aimed to investigate the outcomes of AF ablation in Thailand. Method We performed a retrospective analysis of patients who underwent AF ablation in a tertiary care center, between the years 2006–2020. Details of AF ablation, including pulmonary vein isolation (PVI), and complex fractionated atrial electrogram (CFAE) ablation, were classified. The success rate of AF ablation is determined by freedom from AF beyond 3 months blanking period. Combined success rate of AF ablation was reported along with the success rate of each technique (PVI, CFAE, and combine PVI plus CFAE). Result We identified a total of 171 patients who underwent the first AF ablation. Ninety-four (55%) patients went through PVI, 55 (32%) patients for CFAE ablation, and 22 (13%) patients for PVI plus CFAE ablation. Overall freedom from AF was 73% at 12 months, 66% at 24 months, and 55% at 36 months. The success rate of PVI was 79% at 12 months, 74% at 24 months, and 59% at 36 months. The success rate of CFAE ablation was 63% at 12 months, 51% at 24 months, and 47% at 36 months. Conclusion Catheter ablation of AF is proven safe and effective in Thai population.
Complexity and function of family involvement in advance care planning: A qualitative study of perspectives from people living with advanced cancer, family members and healthcare professionals
Authors: Kishino Megumi , Koffman Jonathan , Nagatomi Hiroaki , Yuasa Misuzu , Ellis-Smith Clare 
Published: September 2023

Background: Family members can support advance care planning conversations. However, how family involvement in advance care planning operates to achieve goal-concordant care remains unclear. Aim: To explore how family involvement impacts the process of advance care planning for advanced cancer patients and their family members to achieve goal-concordant care in Japan. Design: Qualitative study incorporating semi-structured in-depth interviews with thematic analysis informed by Family Systems Theory. Setting/participants: Medical oncology departments at two tertiary hospitals in Japan. A purposive sample of 13 advanced cancer patients, 10 family members and 9 healthcare professionals who cared for them. Results: Twenty-five interviews were conducted, comprising 7 dyads of patients and their family members and 18 individual interviews. Four themes were identified: characteristics of patients and family members and their views on illness and advance care planning; family context and communication; interactions with healthcare professionals and societal and cultural influences; and family members’ acceptance, preparation and confidence. Family involvement was observed as being variable at an individual level and also across generations. Family members provided patients with the instrumental and emotional support that facilitated the advance care planning process. Family involvement enabled family members to better prepare for realising patients’ wishes. It increased family members’ confidence in surrogate decision-making. Conclusions: Two mechanisms of how family involvement may enable goal-concordant care were identified: family members’ support provision and their preparation for realising patients’ wishes. Healthcare professionals should assess family’s readiness to engage in advance care planning, and the time required to prepare them for the process.
Bone marrow edema at ligament insertion is an accurate MRI sign of deltoid ligament injury
Authors: Tong Jiahui , Li Hong , Li Hongyun , Hua Yinghui 
Published: September 2023

Background Magnetic resonance imaging (MRI) is effective in diagnosing deltoid ligament (DL) injury but its sensitivity in chronic cases is low. Additional diagnostic signs are required to reduce the risk of a false negative diagnosis. Purpose To evaluate the added diagnostic value of bone marrow edema at the ligament insertion (BMELI) of DL to the MRI assessment of chronic DL injury. Material and Methods One hundred patients who consecutively came to our institution between November 2018 and December 2021 and underwent arthroscopic surgery for chronic ankle instability (CAI) were enrolled in the present study. Preoperative MR images were retrospectively reviewed by two orthopedic surgeons to evaluate the sensitivity, specificity and interobserver reliability of three MRI signs in diagnosing chronic DL injury, namely, abnormal ligamentous morphological characteristics (ALMC), BMELI and medial clear space (MCS). Results Taking arthroscopy as the reference standard, there were 34 patients with and 66 without DL injury. ALMC had 64.71% (22/34; 46.47–79.70) sensitivity and 83.33% (55/66; 71.71–91.00) specificity, BMELI had 70.59% (24/34; 52.33–84.29) sensitivity and 95.45% (63/66; 86.44–98.82) specificity and MCS had 26.47% (9/34; 13.51–44.65) sensitivity and 92.42% (61/66; 82.50–97.18) specificity. Compared with ALMC, BMELI had similar efficacy in superficial cases ( P = 0.06) and greater efficacy in deep cases ( P = 0.04). All three signs showed good interobserver agreement (kappa values all above 0.7). Conclusion BMELI can reliably indicate concomitant injury to the DL in CAI patients. Using BMELI as a sign of chronic DL injury when ALMC is unclear may reduce the risk of a false negative diagnosis.
Analysis of isotropic stiffened plate structure
Authors: Singh Deepak Kumar , Agarwal Preeti 
Published: September 2023

The analysis of stiffened plate has been carried out using finite element method. The study is divided into static and dynamic analyses. Primarily, free vibration frequencies of the stiffened plate have been determined followed by determination of deflection and von Mises stress for the stiffened plate subjected to the unit uniformly distributed load (1 kN/m2). Further, deflection and von Mises stress are determined, when the plate structure is subjected to hydrostatic loading. The analyses, static and dynamic, have been done using ANSYS Workbench 15.0. A single flat stiffener is used to stiffen the plate structure and the results are evaluated by varying the stiffener geometry, keeping the volume of material almost same as the unstiffened plate. Stiffened plate structure is very popular in the structural engineering domain and has a wide range of engineering applications from ship to aerospace structures. The material used to model stiffener is extracted from the primary plate for keeping the same volume of material. The plate structure is stiffened to reduce the out-of-plane bending even if the same (approximately) amount of material is utilised. Eight-noded plate bending and two-noded beam elements are used to model the plate and stiffener, respectively. The obtained results are compared with the published results and the effect of varying stiffener geometry is further examined. It may be concluded that the response of the stiffened plates are better compared to unstiffened plate even if the same or even less quantity of material is utilised in stiffening. The present findings are useful for the designers when the plate structure is influenced by the surrounding fluid.
Mechanisms of Herba Epimedii in Lung Cancer Treatment: A Combination of Molecular Docking and Network Pharmacology Analyses
Authors: Zhang Jinhua 
Published: September 2023

Introduction Lung cancer (LC) ranks among the most prevalent malignant neoplasms globally. As a Traditional Chinese medicine (TCM), Herba Epimedii has been commonly used for treating LC. However, the specific mechanism of LC remains to be elucidated. Objectives This research aimed to explore the mechanisms of Herba Epimedii in treating LC according to molecular docking and network pharmacology. Materials and Methods The active components (ACs) and targets of Herba Epimedii were screened through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. LC targets were retrieved from GeneCards and DisGeNET databases. Cytoscape v3.9.0 was employed to construct a “drug-component-disease-target” network. The STRING database and Cytoscape 3.9.0 software were utilized to establish a PPI network. The DAVID database was used for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. The AutoDock software was employed for molecular docking verification, and the Pymol software was applied for visual processing. Results Herba Epimedii acted on 108 LC treatment targets through 22 ACs. Five core components were screened, including quercetin, luteolin, kaempferol, anhydroicaritin, and 8-isopentenyl-kaempferol, while 12 core targets were screened, including TP53, AKT1, MYC, CASP3, ESR1, JUN, HIF1A, VEGFA, TNF, CCND1, EGFR, and IL-6. GO enrichment analysis mainly involved positive regulation of gene expression, positive regulation of the apoptotic process, enzyme binding, identical protein binding, macromolecular complex, nucleoplasm, etc. KEGG enrichment analysis mainly involved p53, interleukin-17, PI3K-Akt, and other signaling pathways. Five core components all demonstrated excellent binding activities with the core targets. Conclusion The mechanisms of Herba Epimedii in LC treatment may involve multiple components, targets, and pathways, inducing apoptosis, and inhibiting proliferation, invasion, metastasis, and drug resistance of LC cells.
Tyrosine kinase inhibitor-induced immune hemolytic anemia; three different drugs in three separate cases
Authors: Güzel Halil Göksel , Kıvrak Salim Derya 
Published: September 2023

Introduction Molecular multitargeted small tyrosine kinase inhibitory (TKI) agents such as axitinib, sunitinib and pazopanib are commonly used in several types of solid tumors. Anemia is not a rare effect of these drugs which may occur at all grades. However, drug-induced immune hemolytic anemia (IHA), a very rare condition is distinctive from other types of anemia with its specific mechanism and management strategy. Case Reports We reported three different TKI-induced IHA cases that occurred due to axitinib, sunitinib, and pazopanib, respectively. The first two cases were diagnosed with renal cell carcinoma and the last one was diagnosed with soft tissue sarcoma. They all presented with the characteristic symptoms of anemia and hemolysis. All the cases were detected positive for the complement C3d direct antiglobulin (direct coombs) test. Management and Outcomes Discontinuation of the causative drug and 1 mg/kg/day dose of corticosteroid treatment were able to control IHA in all three cases. Excluding the other factors of IHA and an evident laboratory and clinical benefit after withholding the TKI led to the diagnosis of TKI-related IHA in each case. Discussion TKIs are relatively new in clinical practice and are being used for more indications and in more patients. To our knowledge#these three cases are unique in terms of axitinib#sunitinib#and pazopanib-related IHA.
Optical coherence tomography angiography in birdshot chorioretinopathy
Authors: Pichi Francesco , Lembo Andrea , Nucci Paolo , Neri Piergiorgio 
Published: September 2023

Purpose To describe the retinal vascular changes in birdshot chorioretinopathy (BSCR) using optical coherence tomography angiography (OCTA) and to compare them with changes in macular thickness. Methods In this multicenter study, patients with a diagnosis of BSCR and a positive HLA-A29 underwent fluorescein angiography, spectral domain optical coherence tomography (SD-OCT), and OCTA. The foveal avascular zone (FAZ) and the area of capillary non-perfusion were manually measured by two examiners in fluorescein angiography (FA) and 3 × 3-mm OCTA images of the superficial retinal layer. These measurements were compared to central retinal thickness. To calculate normal capillary density, we collected data from 22 controls who had OCTA performed on one visit only. Results A total of 44 eyes with BSCR were enrolled. The mean automated parafoveal superficial capillary density in BSCR eyes was 0.47 ± 0.03. The differences between the foveal capillary density of BSCR patients and healthy subjects were statistically significant ( P < 0.001). The mean area of FAZ manually measured on the 3 × 3 mm unsegmented OCTA images was larger in eyes with BSCR (1.34 ± 0.41 mm2; P < 0.0001). Measurement of FAZ area showed good interobserver ( κ 0.88) and intraobserver repeatability ( κ 0.79) on OCTA images. The intraclass correlation coefficient for FAZ measurements on FA between the two observers was 0.48. The OCT retinal thickness maps of all BSCR eyes demonstrated statistically significant thinning compared to those of control subjects ( P < 0.01). Conclusion Our study demonstrates the potential contribution of OCTA as a new non-invasive imaging technology that monitors disease activity in BSCR patients.
Tension management and support when leaving a gang
Authors: Forkby Torbjörn , Alstam Kristina , Örnlind Henrik 
Published: September 2023

Summary Gangs are commonly presented in research as an attractive alternative for those who feel excluded and unrecognized in “ordinary” society. Gang life is volatile, however, and violence (open or suppressed) is more or less omnipresent. Exiting a gang seems to be motivated by both thoughts of a better life and disappointment in the gang's failure to meet hopes and expectations. Findings From an analysis of former gang members exit processes, this article investigates what about gang life was stressful and motivated participants dropout, how they coped with tensions, and elaborates how social work could use this tension productively to support people exiting gangs. The data consist primary of interviews with 20 former gang members and 42 professionals. Organizational theory was used in combination with theories on liminality and identity reformation to understand how tensions occurred in gang life, how they were managed, and what caused exit. Applications Social workers may help members exit from gangs by supporting and strengthening their motivations to leave, stimulating their self-reflection, and reminding them of their past transformative. Most important, gang members should be helped to recognize the positive urges that drew them towards gangs and refocus those wishes for community to general society.
U.S. social work students’ attitudes on social media as treatment modality: A prepandemic national survey
Authors: Ricciardelli Lauren A , Dillard Dana R , Quinn Adam E , Skinner Jeff , Nackerud Larry 
Published: September 2023

Summary The present U.S.-based study adds to the ongoing discourse on the ethical use of digital technology in social work practice, made more urgent by the coronavirus disease 2019 (COVID-19). Following the achievement of Human Subjects approval, we obtained a stratified, random sample of 150 institutions of higher education with Council on Social Work Education-accredited undergraduate and graduate social work programs. Prior to COVID-19, we administered a 61-item, Likert-scale survey to social work program directors via email, who then communicated this information to student listservs. A total of 430 social work student responses were retained for analysis. The survey instrument included items related to the students’ social media use, their attitudes toward social media, and their knowledge of social media’s impact on society. Rao-Scott chi-square tests for independence were used to ascertain statistical relationships between U.S. social work students’ responses to the survey item, social media should be used as a treatment modality, and student demographic variables that include: Age, program level, course format, and social media use. Findings Statistically significant relationships were determined to exist between social work students’ endorsement of social media as a treatment modality and: (1) Age and (2) program level. Conversely, no significant relationships were found regarding (1) course format and (2) social media use. Applications Implications for social work professional education are discussed. Recommendations for future social work research are provided: (1) A national replication study; (2) qualitative studies; (3) a comparative study with social work educators and practitioners; (3) a global study; and (4) ongoing evaluation of direct practice methods.
A comparison of chronic conditions and health characteristics between cancer survivors and non-cancer survivors
Authors: Singh Anjin , Gallaway Michael Shayne , Rascon Addey 
Published: September 2023

Objective Cancer survivors have unique healthcare needs. An important consideration for survivorship is chronic diseases and health risk factors. The purpose of this study is to describe demographics, risk factors, and comorbid health conditions in adult cancer survivors. Method We analyzed 2019 Arizona Behavioral Risk Factor Surveillance System data to compare cancer survivors to non-cancer survivors (aged 18 or older) to assess differences between the two populations. Adjusted and unadjusted population-based estimates and 95% confidence intervals were calculated, and multivariable logistic regression models were performed. Results Eight thousand nine-hundred and twenty (8920) respondents (1007 survivors; 7913 non-cancer survivors) were included. Compared to non-cancer survivors, cancer survivors were more likely to be female, 65 years and older, non-Hispanic white, veterans, and less likely to be employed. Survivors had higher rates of coronary heart disease, stroke, chronic obstructive pulmonary disease, kidney disease, hypertension, arthritis, multiple chronic conditions, being overweight, and being a former smoker. Survivors were more likely to report fair/poor health than non-cancer survivors. Discussion These findings can be used by healthcare and public health practitioners to evaluate the programmatic efforts and resources, implement targeted interventions toward cancer survivors, and improve health and quality of life.
METTL3 Regulates the m6A Modification of NEK7 to Inhibit the Formation of Osteoarthritis
Authors: Xiong Xiaochuan , Xiong Hao , Peng Jun , Liu Yingjie , Zong Yang 
Published: September 2023

Objective Osteoarthritis (OA) is a common degenerative joint disease. The occurrence of OA slowly destroys the soft tissue structure of the patient’s joint. Severe cases could lead to disability. Current studies had shown that inhibition of chondrocytes pyroptosis could slow down the progression of OA. Our work aimed to explore the specific mechanisms and ways of regulating this process. Design In this work, the level of N6-methyladenosine (m6A) in clinical tissues was detected by ribonucleic acid (RNA) m6A dot blot. qRT-PCR (quantitative real-time polymerase chain reaction) was used to detect the messenger RNA (mRNA) expression level of m6A modified enzyme in clinical tissues. MTT (3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromid) and flow cytometry were used to detect the effect of sh-METTL3 (methyltransferase like 3) and NIMA-related kinase 7 (NEK7) transfection on chondrocytes pyroptosis in OA. Western blot was used to detect the protein expression levels of pyroptosis-related proteins. ELISA (enzyme-linked immunosorbent assay) was used to measure the protein concentration of inflammatory cytokines. The SRAMP online database was used to predict the m6A site of NEK7. HE staining was used to assess the progression of OA in mice. Results The level of m6A in clinical samples of OA patients was higher, and METTL3 was significantly higher expressed in clinical samples of OA patients. We provided evidence that low expression of METTL3 inhibited chondrocytes pyroptosis. In addition, Rescue experiments and in vivo experiments had shown that METTL3 in combination with NEK7 inhibited the progression of OA by promoting chondrocytes pyroptosis. Conclusions METTL3 regulates m6A modification of NEK7 and inhibits OA progression.
Idiopathic sclerosing dacryoadenitis
Authors: Butterfield Samantha D. , Silkiss Rona Z. 
Published: September 2023

AbstractDacryoadenitis is an inflammation of the lacrimal gland. This condition has an extensive differential diagnosis, requiring a thorough workup to identify the underlying etiology. If no etiology is identified, the condition is termed idiopathic dacryoadenitis. The purpose of this report is to present a case of idiopathic sclerosing dacryoadenitis and review the diagnostic process.We present a case of sclerosing dacryoadenitis non responsive to systemic antibiotics and steroids, improving after surgical debulking/biopsy. Systemic inflammatory and infectious labs were negative. Tissue was negative for SARS-CoV-2 antigen. Histopathologic review of the surgical specimen revealed nonspecific, sclerosing dacryoadenitis, ultimately supporting the diagnosis of idiopathic nonspecific fibrosing dacryoadenitis.This case reviews the presentation, evaluation, and management of a common orbital pathologic condition, with updated recommendations based on the most current literature.