bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic analysis of patients with stage IIIC1p cervical cancer treated by surgery
Authors: Fan Xiang , Wang Yifei , Yang Ni , Zhu Pengfeng 
Published: March 2023

Abstract
Background
Cervical cancer (CC) is one of the most common gynecologic malignancies. The prognosis of patients with stage IIIC1p cervical cancer treated by surgery is heterogeneous. Therefore, the aim of this study was to analyze the factors influencing the prognosis of patients with stage IIIC1p cervical cancer treated by surgery.
Methods
From January 2012 to December 2017,102 patients with cervical cancer who underwent surgical treatment in Department of Gynecology and Tumors, Changzhou Maternal and Child Health Hospital and had pelvic lymph node metastasis confirmed by pathology were analyzed retrospectively. All patients underwent radical hysterectomy with/without oophorectomy with pelvic lymphadenectomy with/without para-aortic lymphadenectomy. Information about the clinical features of patients were collected, including age, surgical method, ovarian status, intraoperative blood loss, perioperative complications, tumor size, pathological type, depth of stromal invasion(DSI), whether lymphatic vascular space was infiltrated, number of pelvic lymph node metastases, location of pelvic lymph node metastases, total number of lymph nodes resected, lymph node ratio(LNR), nature of vaginal margin, whether parametrium was involved, postoperative adjuvant therapy, preoperative neutrophil-lymphocyte ratio (NLR), and prognostic information of patients were followed up. Survival curves for overall survival(OS) and disease-free survival(DFS) were plotted using the Kaplan-Meier method, and the difference between the survival curves was tested using the log-rank test. Univariate and multivariate COX regression models were used to assess the factors associated with overall survival and disease-free survival in patients with IIIC1p cervical cancer. Nomogram plots were constructed to predict OS and DFS, and the predictive accuracy of nomograms was measured by Harrell's C-index and calibration curves.
Results
A total of 102 patients with stage IIIC1p cervical cancer were included in the study, with a median follow-up time of 63 months (range from 6 to 130 months). The 5-year OS was 64.7% and the 5-year DFS was 62.7%. Multivariate analysis showed that no postoperative adjuvant therapy, LNR > 0.3 and NLR > 3.8 were independent risk factors for OS and DFS in patients with stage IIIC1p cervical cancer.
Conclusions
Patients with stage IIIC1p cervical cancer have a poor prognosis. Lower OS and DFS were associated with no postoperative adjuvant therapy, LNR > 0.3, and NLR > 3.8.
Ni(II) complex based on imidazole dicarboxylic acid as a promising electrocatalyst for hydrogen evolution reaction and H2O2-sensing
Authors: Wan Tiantian , Shen Qinqin , Kong Xiaoxia , Li Kaiyi , Wu Huilu 
Published: March 2023

Abstract
A new mononuclear Ni(II) complex, [Ni(p-MOPhH2IDC)2(H2O)2], was synthesized by the reaction of p-MOPhH3IDC (2-(4-methoxyphenyl)-1H-imidazole-4,5-dicarboxylic acid) and Ni(NO3)2·6H2O under solvothermal conditions and characterized by single-crystal X-ray diffraction, elemental analysis, IR and UV-vis spectroscopy. The structure analysis revealed that the nickel center was six-coordinated octahedron coordination geometry. The electrochemical properties of the Ni(II) complex-doped carbon paste electrode (Ni-CPE) were investigated. For electrocatalytic HER (hydrogen evolution reaction), linear sweep voltammetry curves at different temperatures were determined. The polarization curve shows that the η10298K (overpotential, 10 mA cm–2) of the Ni-CPE was positively shifted by 265 mv compared with the bare-CPE (without complex). The Tafel slope of the Ni-CPE was 187 mV dec-1. These indicated that the Ni-CPE was effective for HER electrocatalytic reaction. In addition, the electrochemical sensing performances of the Ni-CPE towards H2O2 were found to have a linear response from 0.5 μM to 4.0 mM with a detection limit of 0.036 μM. The information obtained from this study will help to expand the application of Ni(II) complex in the field of electrochemistry.
Electrochemical Sensitive and Selective Detection of Vitamin-C: Al2O3@PPy Carbon Nanotubes on Modified GCE
Authors: P Manikanta , Navya Byragondanahalli Suresh , . Mounesh , Nikham Rohith Ranganatha , Nagaraja Bhari Mallanna 
Published: March 2023

Abstract
The dispersion of PPy carbon nanotubes catalysts is crucial for the electro-catalytic ability of ascorbic acid (AA), which can be influenced by the fabrication method and the operation process of the catalysts. Therefore, a fabrication method of co-precipitation, have been applied to prepare Al2O3@PPy carbon nanotubes (Al2O3@PPy/CNTs) catalyst. The fabrication method can partially influence the structural and catalytic activity of the AA. The synthesised Al2O3@PPy /CNTs catalyst was confirmed by various spectroscopic methods and as well as electrocatalytic activity of AA by CVs, DPV, and chrono amperometry technique. The results demonstrate that the co-precipitation method is strongly efficient for fabricating PPy carbon nanotubes-based catalysts with a high stability, selectivity, and reproducibility of Al2O3@PPy/CNTs/GC electrode. The fabrication effect can be associated with its low detection limit (1.25 nM L-1), linear range (50 to 700 µM) and sensitivity (7.943 nM µA cm-2), which is achieved via the hot spot mechanism.
The association of obesity with post-cesarean inpatient opioid consumption
Authors: Strong Abigail , Tvina Alina , Harrison Rachel , Watkins Jayla , Afreen Esah , Tsaih Shirng-Wern , Palatnik Anna 
Published: March 2023

Abstract
Background: Obesity and prescription opioid misuse are important public health concerns in the United States. A common intersection occurs when women with obesity undergo cesarean birth and receive narcotic medications for postpartum pain.
Objective: To examine the association between obesity and inpatient opioid use after cesarean birth.
Methods: A retrospective cohort study of patients that underwent cesarean birth in 2015-2018. Primary outcome was post-cesarean delivery opioid consumption starting 24 hours after delivery measured as morphine milliequivalents per hour (MME/hr). Secondary outcome was MME/hr consumption in the highest quartile of all subjects. Opioid consumption was compared between three BMI groups: non-obese BMI 18.5-29.9 kg/m2; obese BMI 30.0-39.9 kg/m2; and morbidly obese BMI ≥ 40.0 kg/m2 using univariable and multivariable analyses.
Results: Of 1,620 patients meeting inclusion criteria, 496 (30.6%) were in the non-obese group, 753 (46.5%) were in the obese group, and 371 (22.9%) were in the morbidly obese group. In the univariate analysis, patients with obesity and morbid obesity required higher MME/hr than patients in the non-obese group [1.3 MME/hr (IQR 0.1, 2.4) vs. 1.6 MME/hr (IQR 0.5, 2.8) vs. 1.8 MME/hr (IQR 0.8, 2.9), for non-obese, obese, and morbidly obese groups respectively, p<0.001]. In the multivariable analysis, this association did not persist. In contrast, subjects in the obese and morbidly obese groups were more likely to be in the highest quartile of MME/hr opioid consumption compared with those in the non-obese group (23.5% vs. 48.1% vs. 28.4%, p<0.001, respectively); with aOR 1.42 (95% CI 1.07-1.89, p-0.016) and aOR 1.60 (95% CI 1.16-2.22, p=0.005) for patients with obesity and morbid obesity, respectively.
Conclusion: Maternal obesity was not associated with higher hourly MME consumption during inpatient stay after cesarean birth. However, patients with obesity and morbid obesity were significantly more likely to be in the top quartile of MME hourly consumption.
A combined rapid clinical and lung ultrasound score for predicting bronchiolitis severity
Authors: Camporesi Anna , Morello Rosa , Guzzardella Amedeo , Pierucci Ugo Maria , Izzo Francesca , De Rose Cristina , Buonsenso Danilo 
Published: March 2023

Abstract
Introduction
Lung Ultrasound (LUS) has demonstrated good correlation with clinical severity scores in bronchiolitis but should be combined with clinical data to achieve best results. Aim of the study is to create a quick and reliable clinical-ultrasound score to predict the risk of Pediatric Intensive Care (Picu) admission as soon as the patient enters the Emergency Department (ED).
Methods
Retrospective study conducted at two pediatric EDs. Lung was divided into six zones and scanned with ultrasound; every zone received a score. Clinical data were obtained. For the outcomes “Picu admission”and “Cpap ventilation”, a multivariate analysis was conducted and the significant factors resulting were used to create a 3- items score to predict Picu admission. Area under the Receiver-Operating Curve (AUC) for specificity and sensibility of the score was obtained.
Results
74 patients were enrolled; 34% were admitted to PICU. 31% were treated with CPAP. For the outcome “PICU admission”, multivariate analysis demonstrated presence of wheezing and reduced oral intake to be significant together with ultrasound involvement of the Right Posterior Upper Zone and Left Posterior Basal Zone. For the outcome “CPAP ventilation”, same clinical factors plus involvement of Right Posterior Upper Zone were significant. A 3-items score (1: presence of wheezing; 2: reduced oral intake; 3: LUS involvement of Right Posterior Upper Zone) for prediction of PICU admission was created which presents an AUC of 0.8249.
Conclusions
We were able to create a simple and quick score to predict need for PICU admission in bronchiolitis.
RTP801 Mediates Transneuronal Toxicity via Extracellular Vesicles by Affecting Their Protein Cargo and Abrogating Their Trophic Effect
Authors: Solana-Balaguer Júlia , Martín-Flores Núria , Garcia-Segura Pol , Campoy-Campos Genís , Pérez-Sisqués Leticia , Chicote-González Almudena , Fernández-Irigoyen Joaquín , Santamaría Enrique , Pérez-Navarro Esther , Alberch Jordi , Malagelada Cristina 
Published: March 2023

Abstract
Background

Extracellular vesicles (EVs) play a crucial role in intercellular communication, participating in the paracrine trophic support or in the propagation of toxic molecules, including proteins. RTP801 is a stress-regulated protein, whose levels are elevated during neurodegeneration and induce neuron death. However, whether RTP801 toxicity is transferred trans-neuronally via EVs remains unknown.

Methods

We overexpressed or silenced RTP801 protein in cultured cortical neurons and isolated the neural-derived EVs (RTP801-EVs, or shRTP801-EVs respectively). We characterized their protein content by mass spectrometry (MS) and western blotting (WB). RTP801-EVs toxicity was assessed by treating cultured neurons with these EVs and quantifying apoptotic neuron death and branching. We also tested shRTP801-EVs functionality in the pathologic in vitro model of 6-Hydroxydopamine (6-OHDA) by biochemical analyses.

Results

Expression of RTP801 increased the number of EVs released by neurons. Moreover, RTP801 led to a distinct proteomic signature of neural-derived EVs, containing more pro-apoptotic markers. Hence, we observed that RTP801 toxicity was transferred to neurons via EVs, activating apoptosis and impairing neuron morphology complexity. In contrast, EVs derived from neurons where RTP801 was silenced were able to increase the arborization of recipient neurons. We also showed that 6-OHDA neurotoxin elevated protein levels of RTP801 in both cell lysates and EVs. Furthermore, neural-derived EVs induced phosphorylation of Ser473-Akt and Ser235/236-RPS6 in recipient neurons, and this effect was lost when EVs were derived from neurons treated with 6-OHDA. Interestingly, EVs derived from neurons where RTP801 was silenced prior to exposing them to 6-OHDA maintained Akt and RPS6 transactivation in recipient neurons.

Conclusion

Taken together, these results suggest that RTP801 toxicity can be spread via EVs and therefore, it could contribute to the progression of neurodegenerative diseases in which RTP801 is involved.
Prognosis Evaluation of Acute Ischemic Stroke After Endovascular Treatment: A Synchronous Study of Transcranial Doppler and Quantitative Electroencephalography
Authors: Qi Yajie , Xing Yingqi , Wang Qingduo , Cao Yanting , Chen Hongxiu , Chen Ying 
Published: March 2023

Abstract
Background: Patients with acute ischemic stroke (AIS) caused by large vessel occlusions who are successfully recanalized may still have a poor prognosis. Transcranial Doppler (TCD) and quantitative electroencephalography (QEEG) were used to assess cerebral blood flow and metabolism, with the goal of identifying patients with severe neurological deficits and poor prognosis at an early stage.
Methods: We prospectively recruited AIS patients with large vessel occlusions with successful recanalization after endovascular treatment and assessed their prognosis at 90 days using the modified Rankin Scale (mRS) score. All patients’ clinical Information, Glasgow Coma Scale (GCS), and National Institute of Health Stroke Scale (NIHSS) scores were recorded. TCD-QEEG was used to evaluate the brain functioning of AIS patients.
Results:Thirty-seven patients (63±11.7 years; 24 males) were studied, and 18 patients had a poor prognosis at 90 days which mRS >3. Multivariable analyses showed that TCD indicators ofUPI (pulsatility index of unaffected side) (odds ratio [OR] 1.076, 95% confidence interval [CI] 1.001–1.157, p=0.048), QEEG indicators of pairwise derived brain symmetry index (pdBSI) (OR 3.041, 95%CI 1.040–8.897, p=0.042), and NIHSS score (OR 1.638, 95%CI 1.071–2.504, p=0.023) were independent predictors of clinical outcomes. The area under the ROC curve for the model combining UPI, pdBSI, and NIHSS scores was 0.980, demonstrating superior predictive accuracy than any single variable.
Conclusions: The combination of TCD, QEEG, and NIHSS scores demonstrated the best prognostic assessment accuracy by assessing cerebral blood flow, metabolism, and neurological function in patients with AIS after revascularization.
Using a Privacy-Enhanced Authentication Process to Secure Internet of Things Infrastructures
Authors: Rostampour Samad , Bagheri Nasour , Ghavami Behnam , Bendavid Ygal , Kumari Saru , Martin Honorio , Camara Carmen 
Published: March 2023

Abstract
Over the last decade, technological advances in smart grids have permitted the modernization of legacy electricity networks. As Internet of Things(IoT)-based smart grids are becoming an efficient response to managing changing electric demand, the heterogeneous network of equipment required to make these Cyber-Physical Systems a reality poses some security threats. This paper proposes a novel mutual authentication and key agreement scheme to ensure communications security and protect users' privacy in smart grid applications. In the proposed scheme (named EPSG), an Elliptic Curve Cryptography (ECC) module and a Physical Unclonable Function (PUF) are used simultaneously to provide acceptable confidentiality and integrity levels. The security analysis demonstrates that the EPSG has a robust security posture regarding transferred messages on the communication channel and physical attacks. In addition, EPSG is resistant to modeling attacks as one of the main vulnerabilities of PUF modules. Furthermore, by implementing the EPSG on an Arduino UNO microcontroller, a comparative performance evaluation in terms of computational complexity, communication overhead, and power consumption demonstrates the efficiency of the proposed EPSG.
Reproducible Clustering with Non-Euclidean Distances: A Simulation and Case Study
Authors: Staples Lauren , Ring Janelle , Fontana Scott , Ray Herman , Zhang Yifan , Zhang Xinyan , Stradwick Christina 
Published: March 2023

Abstract
Certain categorical sequence clustering applications require path connectivity, such as the clustering of DNA, click-paths through web-user sessions, or paths of care clustering with sequences of patient medical billing codes. K-means and k-medoids clustering with non-Euclidean distance metrics such as the Jaccard or edit distances maintains such path connectivity. Although k-means and k-medoids clustering with the Jaccard and edit distances have enjoyed success in these domains, the limits of accurate cluster recovery in these conditions have not yet been defined. As a first step in approaching this goal, we performed a simulated study using k-means and k-medoids clustering with non-Euclidean distances and show the performance deteriorates at a certain level of noise and when the number of clusters increases. However, we identify initialization strategies that improve upon cluster recovery in the presence of noise. We employ the use of the Tibshirani and Guenther (2005) Prediction Strength method, which creates a hypothesis testing scenario that determines if there is clustering structure to the data (if the clusters are reproducible), with the null hypothesis being there is none. We then applied the framework to perinatal episodes of care and the clusters reproducibly and organically split between Cesarean and vaginal deliveries, which itself is not a clinical finding but sensibly validates the approach. Further visualizations of the clusters did bring insights into subclusters that split along groups of physicians, cost and risk scores, warranting the outlined future work into ways of improving this framework for better resolution.
The long noncoding RNA uc003pxg.1 interacts with miR-339-5p to promote TGF-β1 expression and vascular endothelial cell proliferation, migration and angiogenesis in coronary heart disease
Authors: Li Ping , Sun Chenchen , Yan Xinxin , Huang Ying , Xu Jingyi , Wang Feng , Weng Jiayi , Li Yuan , Sun Kangyun 
Published: March 2023

Abstract
This study aims to investigate the roles of lncRNA uc003pxg.1 and miR-339-5p in regulating the proliferation, migration and angiogenesis of vascular endothelial cells and affect the occurrence and development of coronary heart disease (CHD). First, the expression levels of uc003pxg.1 and miR-339-5p were verified in clinical samples, and the correlation between them was analyzed. Then, the target gene was identified using high-throughput sequencing combined with bioinformatics. Human umbilical vein endothelial cells (HUVECs) were transfected with si-uc003pxg.1, miR-339-5p mimic and miR-339-5p inhibitor, and the expression of related genes was detected by RT-qPCR. EdU, CCK8 and Transwell assays were used to analyze the effects of uc003pxg.1 and miR-339-5p on cell proliferation and migration. The protein expression levels were detected by western blotting and angiogenesis was observed. The expression of uc003pxg.1 and miR-339-5p was negatively correlated in clinical samples and HUVECs. si-uc003pxg.1 and miR-339-5p mimic decreased the proliferation and migration of HUVECs and decreased the expression of TGF-β1 and α-SMA. The protein expression levels of TGF-β1, α-SMA, CD31, collage I, collage III and endoglin were decreased, and angiogenesis was weakened. The miR-339-5p inhibitor had the opposite effect. Our study revealed that upregulation of uc003pxg.1 and downregulation of miR-339-5p in vivo promotes cell proliferation, cell migration and angiogenesis, and up-regulates the expression of TGF-β1, α-SMA, CD31, collage I, collage III and endoglin, which may lead to the development of vascular atherosclerosis.
Benign Enlargement of Subarachnoid Spaces in Infancy with Developmental Delay
Authors: Roy Joanna M. , Sawant Vishal Dnyaneshwar , Yadav Jayesh 
Published: March 2023

Abstract
Background
Benign enlargement of subarachnoid spaces (BESS) is a common cause of macro crania in infancy and may present with developmental delay due to enlargement of the brain. The self-limiting nature of this condition allows most children to regain developmental milestones as they grow older. The aetiology of developmental delay in full-term infants with BESS is unclear and prognosis varies since only some children have been reported to have long-term deficit in gross motor and language domains.
Case presentation:
This case report illustrates the clinical profile and findings on brain imaging in a full-term infant who presented with BESS along with delay in attaining age-appropriate gross motor and language milestones. Assessment of developmental milestones at 15 months of age supported the benign nature of this condition although the head circumference remained above the 95th percentile for age.
Conclusions
Despite the self-resolving nature of this condition, regular evaluation of developmental milestones is necessary to ensure timely intervention in appropriate cases. Further research on the aetiology could also aid clinicians in determining which children are at risk for developing long-term developmental delay.
Nonlinear deformation effect of unloading rate on hard rock under different confining pressures
Authors: Jia Lexin , Cong Yu , Qiu Shili , Wang Xiaoshan , Zhang Shirui 
Published: March 2023

Abstract
In this paper, triaxial loading and unloading tests under different loading and unloading conditions are carried out to explore the deformation and failure characteristics of hard rock marble, and the acoustic emission (AE) information of the test process is monitored synchronously to obtain the AE distribution characteristics. The test results show that: (1) when the unloading rate of confining pressure is small, the yield of rock is more obvious, the failure peak value is higher, and the Poisson effect is more obvious under loading and unloading, while when the unloading rate is larger, it shows multi-stage failure; (2) there is a linear relationship between strain deflection stress compliance and unloading rate. With the increase of unloading rate, the circumferential and volumetric compliance increases and the axial compliance decreases; (3) the smaller the unloading rate is, the greater the confining pressure is, and a large number of tensile microcracks in the main shear plane of rock form a shear zone, while the higher the unloading rate is, the smaller the confining pressure is, and the main shear plane runs through; (4) AE counts can characterize the damage degree of marble during loading and unloading. When the confining pressure is low, the damage peak of AE signals increases sharply, and the overall damage increases with the increase of unloading rate, and when the confining pressure is high, AE signals increases gradually. The overall damage decreases with the increase of unloading rate, and a “pre-peak to post-peak” lag effect can occur in the general rock failure.