bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Implementation Uncertainties and Defining Safe Operating Spaces for Deeply Uncertain Cooperative Multi‐City Water Supply Investment Pathways
Authors: Lau Lillian B. , Reed Patrick M. , Gold David F. 
Published: July 2023

AbstractUrban water utilities are increasingly exploring cooperative regional water supply investment and management strategies due to climate change and growing demands. Theoretically, regional cooperative agreements promise improved resource efficiency by realizing economies of scale, adding flexibility for achieving improved supply reliability, and, ideally, limiting individual and collective financial risks. However, there has been little research exploring how implementation uncertainties in the partners' cooperative actions shape infrastructure investment and management pathways' robustness and drive counterparty risks. Counterparty risks potentially exacerbate collaborating partners' vulnerability to the supply and financial challenges they initially sought to mitigate through cooperation. To address these concerns, we introduce the safe operating spaces (SOS) for Deeply Uncertain Water Supply Pathways (DUSOSPathways) framework. The framework, demonstrated on the multi‐city Sedento Valley benchmarking test case, facilitates the formal characterization of the effects of implementation uncertainty within cooperative regional water supply investment and management policy pathways. Results demonstrate the path‐dependent effects of implementation uncertainties in short‐term operational drought mitigation instruments and long‐term infrastructure investments. Our analysis further reveals the potential for increased regional conflict due to asymmetries between partners' vulnerabilities to the actions of cooperating partners that can be exacerbated by other deeply uncertain factors that reduce their robustness (e.g., demand growth rates). The study finally delineates SOS, beyond which utilities experience robustness degradation and increased vulnerabilities to future uncertainties to guide implementation of cooperative policy pathways. Overall, this framework is broadly applicable to regional systems seeking to navigate complex cooperative regional water supply investment and management policy pathways.
A fast, low-cost, robust and high-throughput method for viral nucleic acid isolation based on NAxtra magnetic nanoparticles
Authors: Ravlo Erlend , Sousa Mirta Mittelstedt Leal de , Andersen Lise Lima , Holberg-Petersen Mona , Klundby Ingvild , Aas Per Arne , Hagen Lars , Erlandsen Sten Even , Malmring Janne Fossum , Ali Zeeshan , Sharma Anuvansh , Ottesen Vegar , Bandyopadhyay Sulalit , Bjørås Magnar 
Published: July 2023

AbstractThe year of 2020 was profoundly marked by a global pandemic caused by a strain of coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19). To control disease spread, a key strategy adopted by many countries was the regular testing of individuals for infection. This led to the rapid development of diagnostic testing technologies. In Norway, within a week, our group developed a test kit to quickly isolate viral RNA and safely detect SARS-CoV-2 infection with sensitivity comparable to available kits. Herein, the procedure employed for the detection of SARS-CoV-2 in swab samples from patients using the NTNU-COVID-19 test kit is described in detail. This procedure, based on NAxtra magnetic nanoparticles and an optimized nucleic acid extraction procedure, is robust, reliable, and straightforward, providing high-quality nucleic acids within 14 min. The NAxtra protocol is adaptable and was further validated for extraction of DNA and RNA from other types of viruses. A comparison of the protocol on different liquid handling systems is also presented. Due to the simplicity and low cost of this method, implementation of this technology to diagnose virus infections on a clinical setting would benefit health care systems, promoting sustainability.
Die Tyrannei der Angst
Authors: Trebin Ernst 
Published: July 2023

ZusammenfassungNach einem kurzen Überblick über die uns in der Behandlung von
Angststörungen zur Verfügung stehenden homöopathischen
Arzneien schildert der Autor einen erfolgreichen Behandlungsverlauf. Die
Patientin stand schon in längerer konstitutioneller Therapie, als eine
zuvor nicht gekannte Panik über sie hereinbrach. Das zunächst
konfuse Bild bedurfte eines längeren Anlaufs, bis nicht nur eine
passende Arznei gefunden wurde, sondern diese auch eine spürbare Wirkung
zeigte. Zur weitgehenden und nachhaltigen Stabilisierung bedurfte es allerdings
einiger Jahre der Behandlung mit einer klaren Grundlinie, aber auch mit
ergänzenden und flankierenden Mitteln.
Verschreibungen von Muttermitteln aufgrund der Causa
Authors: Wittwer Heinz 
Published: July 2023

ZusammenfassungDas Gefühlsleben einer schwangeren Mutter stellt die tiefste
Prägung eines werdenden Kindes dar. Ohne spezifische Therapie bestimmen
prä- und perinatale Erlebnisse ein Leben lang die Grundtonalität
der Gefühlslage eines Menschen. Eine homöopathische Behandlung
ist in der Lage, prä- und perinatale Traumen zu mildern und
aufzulösen. Dazu haben sich in erster Linie die sogenannten Muttermittel
bewährt, die naturgemäß einen großen Bezug zu
Schwangerschaft und Geburt aufweisen. Falls anamnestische Informationen zu
prä- und perinatalen Ereignissen vorliegen, kann das passende
Muttermittel oft aufgrund der Causa verschrieben werden. Solche Verschreibungen
sind einfach und gelten als sehr zuverlässig.
Brustimplantat assoziiertes Plattenepithelkarzinom (BIA-SCC)
– eine systematische Literaturübersicht
Authors: Möllhoff Nicholas , Ehrl Denis , Fuchs Benedikt , Frank Konstantin , Alt Verena , Mayr Doris , Braig David , Giunta Riccardo E. , Hagen Christine 
Published: July 2023

Zusammenfassung
Hintergrund Das Brustimplantat assoziierte Plattenepithelkarzinom
(BIA-SCC) wird als eigenständige, von der Implantatkapsel ausgehende,
maligne Tumorentität diskutiert. Die FDA und die ASPS
veröffentlichten 2022 eine Mitteilung zum BIA-SCC, wobei bereits in den
1990er Jahren erstmalig ein Fallbericht von BIA-SCC erschien. Das Manuskript
fasst die aktuelle wissenschaftliche Datenlage zu dieser seltenen
Tumorentität zusammen.
Material und Methoden Die Literaturübersicht basiert auf einer
systematischen Datenabfrage aus zwei unabhängigen Datenbanken und
schließt alle Veröffentlichungen von Fällen mit
histopathologisch gesichertem BIA-SCC ein. Die Datenextraktion umfasste
Studiendesign, demografische Daten, Informationen zu den Implantaten, sowie
Details zur Diagnostik und Therapie.
Ergebnisse Die Recherche ergab 19 BIA-SCC-Fälle in 16
Publikationen, mit einem Durchschnittsalter von 57±10 Jahren. Die
Indikation zur Verwendung eines Brustimplantates war in den meisten
Fällen eine ästhetische Brustvergrößerung
(n=13). Sowohl silikon- (n=11), als auch kochsalzhaltige
(n=7) Implantate mit unterschiedlichen Oberflächen (glatt
n=3, texturiert n=3, polyurethan n=1) wurden eingesetzt.
Symptome wie einseitige Schwellung (n=18), Schmerzen (n=14) und
Erythem (n=5) traten im Durchschnitt 23±9 Jahre nach
Implantation auf. Die Bildgebung zeigte einen Flüssigkeitssaum
(n=8) oder eine Tumormasse (n=4) um das Brustimplantat. Die
häufigste chirurgische Therapie war die Explantation mit Kapsulektomie.
In 6 Fällen wurde eine Metastasierung beschrieben.
Schlussfolgerung Das BIA-SCC ist eine maligne Tumorentität, die
mit Brustimplantaten und der Kapsel um Brustimplantate in Verbindung gebracht
wird. Zum aktuellen Zeitpunkt kann aufgrund der Datenlage aus Studien mit
niedrigem Evidenzgrad V keine endgültige Aussage bezüglich
Korrelation und Kausalität des SCC in Patient*innen mit
Brustimplantaten erfolgen. Es besteht dringender Bedarf nationaler und
internationaler Brustimplantat- und Brustkrebsregister, um valide Daten zu
Inzidenz, Pathogenese, und Klinik seltener Tumorentitäten zu
erlangen.
Bone Graft Substitutes and Enhancement in Craniomaxillofacial Surgery
Authors: Patel Dhruv , Tatum Sherard A. 
Published: July 2023

AbstractCritical-sized bone defects are a reconstructive challenge, particularly in the craniomaxillofacial (CMF) skeleton. The “gold standard” of autologous bone grafting has been the work horse of reconstruction in both congenital and acquired defects of CMF skeleton. Autologous bone has the proper balance of the protein (or organic) matrix and mineral components with no immune response. Organic and mineral adjuncts exist that offer varying degrees of osteogenic, osteoconductive, osteoinductive, and osteostimulative properties needed for treatment of critical-sized defects. In this review, we discuss the various mostly organic and mostly mineral bone graft substitutes available for autologous bone grafting. Primarily organic bone graft substitutes/enhancers, including bone morphogenic protein, platelet-rich plasma, and other growth factors, have been utilized to support de novo bone growth in setting of critical-sized bone defects. Primarily mineral options, including various calcium salt formulation (calcium sulfate/phosphate/apatite) and bioactive glasses have been long utilized for their similar composition to bone. Yet, a bone graft substitute that can supplant autologous bone grafting is still elusive. However, case-specific utilization of bone graft substitutes offers a wider array of reconstructive options.
Impacts of climate change on animal welfare
Authors: Joseph Joe , Charalambous Renae , Pahuja Harsh , Fox Dylan , Jeon Jiwoo , Ko Ning-Yuan , Rao Nishit , Wang Zhiheng , Nerurkar Sneh Kashinath , Sherekar Sharvari Avinash , Yang Yifei , Regester Kate Dutton- , Narayan Edward 
Published: July 2023

Abstract

Climate change has a significant impact on domesticated and wildlife animals globally. Projections for a 2°C rise in atmospheric temperature will result in catastrophic impacts globally. Animal welfare is an integral component of human-animal interaction and it is of paramount importance for wildlife rehabilitation and domestic animals. Animal welfare can be assessed using the five domains model, which includes nutrition, environment, physical health, behaviour, and mental attributes of an animal’s response to environmental change. Researchers use some of these domain attributes to evaluate the effects of stress on their animals and to improve the management and welfare of animals. Although there are variations in how animals respond biologically to stress, in general, the five domains model provides a robust tool for research use, and to evaluate the proximate effects of climatic variability on animals. In this review, our research group (The Stress Lab;
www.edwardstresslab.org
) presents a series of wildlife and domesticated animal examples to showcase how climate change impacts animal welfare. We provide examples of animals from various countries, across both aquatic and terrestrial systems, and provide an overview of the impacts of climate change on each of the five domains of animal welfare. We hope that future researchers will apply the animal welfare domains to evaluate how climate change impacts animals, and further research will pave the way to the protection of animals from the catastrophic impacts of climate change.
Weight-based vs fixed dosing of darbepoetin alfa for anemia following kidney transplantation
Authors: Solis Jonathan , Wilson Nicole , Sam Teena , Ma Tsung-Wei , Yango Angelito , Fischbach Bernard , Kataria Ann D 
Published: July 2023

Abstract

Purpose
Post-transplantation anemia (PTA) is common in kidney transplant recipients, with patients frequently treated with erythropoietin-stimulating agents such as darbepoetin alfa. The optimal dosing for darbepoetin alfa remains controversial.

Methods
This retrospective cohort study involved kidney transplant recipients who received darbepoetin alfa at 2 clinics. Patients were stratified into 2 groups: those who received a fixed dose of 200 μg and those who received a weight-based dose of 0.45 μg/kg. The dosing interval varied depending on clinical response, clinic visit timing, and frequency allowed by insurance. The primary outcome was achieving a hemoglobin concentration of at least 10 g/dL without blood transfusion by 12 weeks after darbepoetin alfa initiation.

Results
Of the 110 patients in the study, 45% received weight-based dosing and 55% received fixed dosing. Darbepoetin alfa was initiated significantly earlier after transplantation in the fixed-dose group (median of 14 vs 20 days; P = 0.003). The weight-based group received more doses of darbepoetin alfa (median of 4 vs 2 doses; P = 0.002) and had a significantly lower cumulative exposure to darbepoetin alfa (125 vs 590 μg; P &lt; 0.001). The median time between doses was 9 days (interquartile range, 7-14 days) in the weight-based group and 12 days (7-32 days) in the fixed-dose group (P = 0.04). Patients in the weight-based group more frequently achieved the primary outcome (67.3% vs 47.5%; P = 0.059). There was no significant difference in secondary or safety outcomes between the groups.

Conclusion
Weight-based and fixed dosing approaches for darbepoetin alfa were not different in the achievement of a hemoglobin concentration of at least 10 g/dL without blood transfusion at 12 weeks after darbepoetin alfa initiation, with significantly lower cumulative darbepoetin alfa utilization in the weight-based group. Weight-based dosing of darbepoetin alfa in PTA appears to be safe and effective, with the potential for significant patient and health-system cost savings.
Return-to-work following shoulder arthroplasty in adults with osteoarthritis
Authors: Kuijpers T I M , Vossen R J M , Kuijer P P F M , Alta T D , Sierevelt I N , Van Noort A 
Published: July 2023

Abstract

Background
Anatomic total shoulder arthroplasty (aTSA) and hemiarthroplasty (HA) have demonstrated significant improvement in shoulder function and pain relief. Work-related outcomes have become increasingly important, while the current literature lacks evidence related to return-to-work (RTW) and which factors might have an influence on it.

Aims
This study aimed to assess RTW in patients who have received aTSA or HA at a minimum of 1-year follow-up after surgery, and secondary to evaluate possible prognostic factors associated with RTW.

Methods
We performed a retrospective query in employed patients diagnosed with primary osteoarthritis of the shoulder, who received either an aTSA or HA between February 2006 and February 2021. Preoperative and post-operative work and sports participation were assessed.

Results
Forty-four patients participated in this study (98% compliance), of which 40 patients (91%) were able to RTW at a median time of two (interquartile range: 2–4) months post-operatively. Patients with a medium-/high-demand occupation demonstrated RTW at a significantly lower rate (79%) than those with light-demand occupations (100%; P = 0.03). There was a statistically significant association between return to full employment and patients’ expectation to fully return, absence of preoperative work adjustments and preoperative sick leave (odds ratio: 16.9 [3.1–93.5]; 18.3 [2.1–160.4]; 0.1 [0.0–0.6]).

Conclusions
aTSA and HA facilitate excellent RTW rates. Patients with a medium-/high-demand occupation return at a significantly lower rate. The ability to RTW seems to be multifactorial and the results found might not be attributed to shoulder arthroplasty alone.
Filming the Photographer
Authors: Hallas Roger 
Published: July 2023

Abstract
Chapter 3 explores how documentary film tackles the challenge of filming photographers at work. Whereas filming other types of visual artists, such as painters or sculptors, allows viewers to witness the cumulative process of the work’s aesthetic creation, filming photography must address the challenge of the medium’s predominant reliance on instantaneous capture (particularly in photojournalism). Since the durational quality of film makes it easier to miss the “decisive moment” captured by the documentary photographer’s camera, photographer documentaries have long turned to imitating the photographer’s aesthetic through their cinematography. The chapter analyzes films about contemporary documentary photographers that have transformed such “aesthetic mimicry” from a popularized form of aesthetic apprenticeship into diverse opportunities for opening up critical and ethical engagement with the photographer’s practice, permitting new perspectives on the event of photography to emerge.
Morality in the Making of Sense and Self
Authors: Hollander Matthew M. , Turowetz Jason 
Published: July 2023

Abstract
For over half a century, Stanley Milgram’s classic and controversial obedience experiments have been a touchstone in the social and behavioral sciences, introducing generations of students to the concept of destructive obedience to authority and the Holocaust. In the last decade, the interdisciplinary Milgram renaissance has led to widespread interest in rethinking and challenging the context and nature of his Obedience Experiment. In Morality in the Making of Sense and Self, Matthew M. Hollander and Jason Turowetz offer a new explanation of obedience and defiance in Milgram’s lab. Examining one of the largest collections of Milgram’s original audiotapes, they scrutinize participant behavior in not only the experiments themselves, but also recordings of the subsequent debriefing interviews in which participants were asked to reflect on their actions. Taking an interaction centered approach to the sociology of morality, they show that, contrary to traditional understandings of Milgram’s experiments that highlight obedience, virtually all subjects, both compliant and defiant, mobilized practices to resist the authority’s commands, such that all were obedient and disobedient to varying degrees. As Hollander and Turowetz show, whether participants explicitly defined the situation as a moral problem mattered greatly for the outcomes they achieved, shaping their response to the authority’s demands and ultimately whether they would be classified as “obedient” or “defiant.” By illuminating the relationship between concrete moral dilemmas and social interaction, Hollander and Turowetz tell a new, empirically-grounded story about Milgram: one about morality—and immorality—in the making of sense and self.
Self- and Other-Attentive Resistance
Authors: Hollander Matthew M. , Turowetz Jason 
Published: July 2023

Abstract
Following from the previous chapter’s analysis of forms of resistance in Milgram’s lab, Chapter 5 focuses on Obedient and Disobedient participants’ practices for making the moral implications of interactional trouble explicit. Accordingly, we pay particular attention to the composition of explicitly resistive turns in Participant-Experimenter interaction: to the design features of actions through which resistance is performed, which include questions, reports, formulations, and accounts, and the ways in which these actions make explicit the moral implications of the situation. In comparing how Obedient and Disobedient participants performed explicit resistance, we show that (1) such resistance can be grouped into self- and other-oriented resistance, (2) members of both outcome groups displayed both types of resistance as well as a preference for other-oriented resistance, and (3) Disobedient participants displayed both types of resistance more frequently than did their Obedient counterparts, as well as two types of explicit resistance that Obedient participants never or almost never display: Golden Rule accounts and Letting the Learner Decide. The chapter first describes the organization and distribution of explicit resistance in the Milgram experiment. Second, we examine self- and other-oriented resistive practices among Obedient participants. Third, we examine these two types of resistance among Disobedient participants, comparing and contrasting their use of these practices with that of Obedient participants. Finally, we reflect on our findings and conclude both the chapter and Part II of the book.
Milgram, Science, and Morality
Authors: Hollander Matthew M. , Turowetz Jason 
Published: July 2023

Abstract
Chapter 7 continues the previous chapter’s analysis of Milgram’s debriefing interviews, focusing on his attempts to change participants’ feelings about the experiment as well as how he organized the experiments to induce strong emotional reactions. Whereas previous chapters dealt with how participants responded to the experiment, this chapter highlights the affective labor Milgram and his confederates put into their research. Drawing on recent scholarship in feminist science studies, the chapter analyzes the conduct of the experiment as a matter of care for Milgram. The emotional labor involved in the experiments is evident in Milgram’s efforts to retroactively transform the affective and moral meanings participants attached to them, as well as his constant tinkering with his setup. The chapter shows how Milgram, via the Experimenter, sought to achieve reconciliation with participants through practices of news delivery and assessment, in the process changing their negative and ambivalent pre-debriefing assessments of the experiment into positive ones. That debriefings were not merely informative but also transformative explains the puzzle of how participants could voice negative feelings toward the experiment prior to debriefing yet report positive feelings on surveys they filled out weeks or months later. Finally, the chapter considers Milgram’s use of science as a resource for persuading participants that they were contributing to something meaningful—the scientific enterprise.
Before the Scrolls
Authors: Mastnjak Nathan 
Published: July 2023

Abstract
Before the Scrolls: A Material Approach to Israel’s Prophetic Library traces the media history of the biblical prophetic corpus in order to propose a material approach to biblical literature. Though often ignored, the realia of a text’s form, format, production, and material substance have profound influence on the meaning of the text. The literature of the Bible was not initially written as discrete books with determined beginnings, middles, and ends. Before the Scrolls argues instead that biblical compositions of length, such as the great prophetic books Isaiah, Jeremiah, and Ezekiel, were initially written on loosely organized collections of multiple short papyrus scrolls. Only later in the Hellenistic era were these compositions edited, organized, and copied into the longer book-scrolls known from the Dead Sea. The shift from prophetic library to linear prophetic book-scroll represents a transformation in material medium that had significant effects on that literature. This material approach to the prophetic corpus suggests novel solutions to classic problems in the field such as the relationship between the MT and LXX of Jeremiah and between the First and Second Isaiah. The failure to account for the materiality of the prophetic corpus has led scholarship to occasionally ask the wrong questions of these compositions and has blinded it to the vital role that Hellenistic bookmakers played in the creation of the Bible as we know it.
The Materiality of the Prophetic Literature
Authors: Mastnjak Nathan 
Published: July 2023

Abstract
The nature and origins of the Israelite prophetic book remains a major contested topic in scholarship on the Hebrew Bible. Chapter 1 introduces this basic problem and argues that it is necessary to give attention to the materials and formats of prophetic scrolls. The field of book history provides a conceptual framework for thinking through these material realities. As D. F. McKenzie has argued, the material format of a book has an expressive function that cannot be ignored in any attempt to describe the meaning of a text or to write a history of the book. Before the Scrolls proposes a history of the prophetic scroll as a point of entry for a material approach to the books of the Bible.