bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concomitant Human Papillomavirus (HPV) Vaccination and HPV Screening for Rapid Elimination of HPV Infection and Cervical Cancer
Authors: Dillner Joakim , Muhr Laila Sara Arroyo , Gini Andrea , Yilmaz Emel , Hassan Sadaf , Lagheden Camilla , Hultin Emilie , Serrano Ainhoa Garcia , Ure Agustin , Andersson Helena , Merino Roxana Martinez , Elfström K. , Baussano Iacopo 
Published: September 2023

Abstract

We describe a nationwide implementation trial of concomitant Human Papillomavirus (HPV) vaccination and HPV screening of young women to reduce the incidence of HPV and provide HPV screening-mediated protection against cervical cancer. All 89,547 women born 1994-1999 resident in the capital region of Sweden were personally invited to concomitant vaccination and screening with 26,125 women (29,2%) enrolling. HPV genotyping found a strong decline of HPV16 and 18 in birth cohorts previously offered vaccination, but no decline for HPV types not targeted by vaccines. Our dynamic transmission modelling predicted that the trial could reduce the incidence of high-risk HPV infections among the 1994-1998 cohorts by 64-69% in 3 years. At baseline, we demonstrated feasibility, validated transmission model projections, and obtained power estimates. At follow-up, the trial can estimate HPV incidence reductions of +/-0.1% with 99.9% confidence.
Clinicaltrials.gov identifier: NCT04910802.
Clinical Efficacy of the Mulligan Maneuver for Cervicogenic Headache: A Randomized Controlled Trial
Authors: Jin Xin , Du Hong-Gen , Kong Ning , Shen Jian-Liang , chen Wen-Jun 
Published: September 2023

Abstract
Background
Cervicogenic headache is an often observed secondary headache in clinical settings, with patients who endure prolonged and persistent pain being particularly susceptible to mood changes.Currently, the Mulligan is one of the effective methods for CEH. However, there is a lack of evaluation about the strength and frequency of headaches, as well as the assessment of pain-induced emotions, in individuals with CEH using this particular procedure. Herein, we aimed to evaluate the effectiveness of the Mulligan maneuver from a multidimensional perspective of pain intensity and mood.
Methods༚
A total of forty patients diagnosed with CEH who satisfied the specified inclusion criteria were recruited and allocated randomly into two groups: the control group and the treatment group, with each group consisting of twenty cases. The control group received health education, while the treatment group received the Mulligan maneuver once daily over a course of 10 treatment sessions.The clinical outcome of patients with CEH in two groups was assessed using the Visual Analog Scale (VAS), Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HAMD). Resting-state functional magnetic resonance imaging (fMRI) was employed to examine variations in brain function activities between the two CEH groups. Brain regions showing differences were identified as regions of interest (ROI) and subsequently correlated with clinical behavioral measures using Pearson's correlation analysis.
Results
The differences in VAS, HAMA and HAMD between the two groups of CEH patients were also statistically significant (P < 0.05). The brain regions that showed differences in the ReHo scores between the two groups of CEH patients included the left cerebellum, the frontal gyrus, and the middle temporal gyrus. There was a positive correlation between the left frontal gyrus and VAS, HAMA and HAMD. (R2 = 0.48, P < 0.05; R2 = 0.28, P < 0.05; R2 = 0.26, P < 0.05); the left middle temporal gyrus had a negative correlation with VAS, HAMA, and HAMD. (R2 = 0.44, P < 0.05; R2 = 0.43, P < 0.05; R2 = 0.25, P < 0.05); and the left cerebellum had a positive correlation with VAS correlation (R2 = 0.27, P < 0.05).
Conclusion
The Mulligan maneuver may improve pain levels and have a moderating effect on pain-related negative emotions by regulating the function of relevant brain regions in CEH patients.
The Role of Cervical Elastography in the Differential Diagnosis of Preinvasive and invasive Lesions of the Cervix
Authors: yücel ecem , Yıldırım Hande Esra Koca , çakır caner , korkmaz vakkas 
Published: September 2023

Abstract
Study Objective

This study aims to evaluate the role of cervical elastography in the differential diagnosis of preinvasive and invasive lesions of the cervix.

Materials and Methods

A total of 95 women participated in this prospective study and were divided into the following groups: 19 healthy subjects (group 1) with normal cervicovaginal smear (CVS) and negative human papillomavirus test (HPV DNA), 19 women with normal cervical biopsy and normal final pathological result of cervical biopsy (group 2), 19 women with low-grade squamous intraepithelial lesion (LSIL) (group 3), 19 women with high-grade squamous intraepithelial lesion (HSIL) (group 4), 19 women with cervical cancer (group 5). Clinical, demographic, histopathological, and elastographic results were compared between these groups.

Results

Comparing groups, age (40.42±8.31 vs. 39.53±8.96 vs. 38.79±9.53 vs. 40.74±7.42 vs. 54.63±12.93, p<0.001 respectively), gravida (1.74±1.33 vs. 2.16±1.68 vs. 2.21±1.96 vs. 2.53±1.93 vs. 4.63±2.17 p<0.001 respectively), parity (1.37±0.68 vs. 1.68±1.20 vs. 1.58±1.30 vs. 2.00±1.67 vs. 3.37±1.61, p<0.001 respectively) and the proportion of patients at menopause (10.5% vs., 15.8% vs, 10.5% vs, 5.3% vs, 57.9%, p<0.01 respectively) a statistically significant difference was found (Table 1). However, no statistically significant difference was found in the number of abortions, BMI, mode of delivery, smoking, additional disease status, history of surgery, and family history (p> 0.05) (Table 2). As a result of the applied roc analysis, mean cervical elastographic stiffness degree (ESD) was found to be an influential factor in predicting cervical cancer (p<0.05). The mean cut-off value was 44.65%, with a sensitivity of 94.7% and a specificity of 96.1% (Table 7)

Conclusıon

Measurement of ESD by elastography is a low-cost, easily applicable, and non-invasive indicator that can distinguish cervical cancer from normal cervical and preinvasive lesions. However, it is unsuitable for determining preinvasive cervical lesions from normal cervix.
Effect of silicon on the synthesis of iron aluminides from elemental powders
Authors: Khoshhal Razieh , Abad Seyed Vahid Alavi Nezhad Khalil 
Published: September 2023

Abstract
Iron aluminides have been receiving much attention due to their excellent properties such as light weight, high strength, oxidation resistance, and corrosion resistance. These types of materials are made in a variety of methods. Various types of additives such as Si, Cr, Ta, and Nb have been added to iron aluminides to improve their properties. Silicon is one of the most effective additives. There are no comprehensive studies that can prove the final product of the Fe-Al powder system reactions in the presence of silicon. Therefore, equal molar ratios of Fe and Al powders were mixed with different amounts of Si to investigate the effect of silicon on the reactions of Fe-Al/Si powder system. The obtained samples were heat-treated at 950°C in an argon atmosphere. It has been found that the presence of silicon affects not only the type of iron aluminides and iron silicides produced but also the final morphology.
Impact of enriched environment on motor performance and learning in mice
Authors: Dijkhuizen S. , Ginneken L.M.C. Van , Ijpelaar A.H.C. , Koekkoek S.K.E. , de Zeeuw C.I. , Boele H.J. 
Published: September 2023

Abstract
Neuroscience heavily relies on animal welfare in laboratory rodents as it can significantly affect brain development, cognitive function, and memory formation. Unfortunately, laboratory animals are often raised in artificial environments devoid of physical and social stimuli, potentially leading to biased outcomes in behavioural assays. To assess this effect, we examined the impact of social and physical cage enrichment on various forms of motor coordination. Our findings indicate that while enriched-housed animals did not exhibit faster learning in eyeblink conditioning, the timing of their conditioned responses was slightly, but significantly, improved. Additionally, enriched-housed animals outperformed animals that were housed in standard conditions in the accelerating rotarod and ErasmusLadder test. In contrast, we found no significant effect of enrichment on the balance beam and grip strength test. Overall, our data suggest that an enriched environment can improve motor performance and motor learning under challenging and/or novel circumstances, possibly reflecting an altered state of anxiety.
Adaptive Weighted Feature Fusion for Multiscale Atrous Convolution based 1DCNN with Dilated LSTM-aided Fake News Detection using Regional
Authors: Vasu Rathinapriya , Kalaivani J. 
Published: September 2023

Abstract
The people present in the world rely on social media for gathering news, and it is mainly because of the development of technologies. The approaches employed in natural language processing are still deficient in judgment factors, and these techniques frequently rely upon political or social circumstances. Numerous low-level communities in the area are curious after experiencing the negative effects caused by the spread of false information in different sectors. Low-resource languages are still distracted, considering the fact that these techniques are extensively employed in the English language. This work aims to provide an analysis of regional language fake news and develop a referral system with advanced techniques to identify fake news in Hindi and Tamil. This proposed model includes (a) Regional Language Text Collection, (b) Text pre-processing, (c) Feature Extraction, (d) Weighted Stacked Feature Fusion, and (e) Fake News Detection. The text data is collected from the standard datasets. The collected text data is pre-processed and given into the feature extraction using Bidirectional Encoder Representations from Transformers (BERT), Transformer networks, and seq2seq network for extracting the three sets of language text features. These extracted feature sets are inserted into the weighted stacked feature fusion model, where the three sets of extracted features are integrated with the optimized weights that are acquired through the Enhanced Osprey Optimization Algorithm (EOOA). Here, weighted fused features are accomplished and passed toward the fake news detection phase. Fake news detection is performed with Multi-scale Atrous Convolution-based One-Dimensional Convolutional Neural Network with Dilated Long Short Term Memory (MACNN-DLSTM). The fake news in the regional language is detected finally. The experimental analysis is carried out by comparing with the conventional algorithms and detection techniques to showcase the efficiency of the developed regional language-based fake news detection model.
Nutrient traits of deadwood driving wood-inhabiting fungal distribution during wood decaying in a temperate natural forest
Authors: Wei Yulian , Li Qiushi , Wu Qinxue , Li Tong , Yuan Haisheng , Xu Zhihong 
Published: September 2023

Abstract
Background
Deadwood is an important structural component of forest ecosystem and its decaying process is crucial for nutrient cycles. Wood-inhabiting fungi play the vital function in the decomposition of deadwood. The composition of wood-inhabiting fungal communities change over the course of the deadwood decaying process. As the typical forest, the temperate broad-leaved Korean pine mixed forest of Changbaishan Nature Reserve (CBS) has been the studying focus area. Since the wood-inhabiting fungal communities of deadwood would still be litter known, we need to reveal wood properties, differences between wood-inhabiting fungal communities of different tree species during process of the wood decomposition and the main influencing factors. To achieve this goal, we exposed deadwood logs of 7 dominant tree species in CBS, covering gymnosperm and angiosperm with three decaying levels.
Results
We found the distinct varieties of wood properties, including total C, total N and total P etc. between different tree species and decaying levels. These factors caused the different wood-inhabiting fungal community composition of deadwood between whether tree species or decaying levels. The 50 dominant fungal species showed the clear nutrient preference. In general, most Basidiomycota tend to use woody substrate with high N content while most Ascomycota prefer high P content. Some of them may like high C content more.
Conclusions
The composition of wood-inhabiting fungal communities changed both over the course of the deadwood decaying process and between the different host tree species. The results of NMDS analysis of wood-inhabiting fungal community of seven tree species logs with three decay levels showed that the nutrients of deadwood, etc total C, total N and total P content, were the main driving factor. The preference of dominant fungal species represent the community it is located in a certain.
Experimental Study on Failure Mode and Fracture Evolution Characteristics of Red Shale in Kaiyang Phosphorus Mining Area
Authors: MA Zhenqian , ZHOU Lang , ZUO Shaojie , ZHANG Jimin 
Published: September 2023

Abstract

In order to study the failure mode and fracture evolution characteristics of red shale in Kaiyang Phosphorus mining area, conventional triaxial compression mechanical tests of red shale with different bedding dip angles were carried out by using DSTD-1000 electro-hydraulic servo rock mechanics experiment system. Based on the laboratory test results, the conventional triaxial particle flow simulation of red shale samples with different bedding dip angles was carried out using discrete element PFC2D. The results show that: (1) the failure mode of red shale is controlled by bedrock when the bedding dip angle is 0° and 60°~ 90°. When the bedding dip angle is 15°~ 45°, the rock failure mode is controlled by bedding. The compressive strength of rock is the minimum when the bedding dip angle is 30°and the maximum at 0°, which is about 2 times of the minimum. (2)In the failure process of red shale, the cracks with different bedding dip angles show slow growth stage, accelerated growth stage and stable stage with axial strain. The whole failure process is dominated by tensile cracks, accompanied by a few shear cracks. (3)The type of displacement field varies with the bedding dip angle: tensile failure and shear failure are the main displacement field types at 15°~ 45°, and mixed failure is often the main mode at 60°~ 90°and 0°. The research results provide the basis and reference for the safety control of red shale roadway.
Analysis of control impact on the HIV reproductive cycle in a cross infection epidemic model
Authors: GIAMBERARDINO Paolo DI , Iacoviello Daniela 
Published: September 2023

Abstract

Despite the great advances in HIV treatment, there are still several processes in the dynamics of the infection that are not yet fully understood. Some evidences show that when the therapy HAART is suspended, infection resumes, suggesting the existence of virus reservoirs; these have been identified in the lungs, brain and guts. In this paper, following the compartmental approach, a recently proposed model is addressed, considering in particular the brain as reservoir and distinguishing the cells depending on whether they are inside or outside the brain, both infected and non infected. Controls mimicking the drug action are introduced and the model is analysed in terms of equilibrium points and stability, also determining the reproduction number. Numerical results are used to put in evidence the main dynamics characteristics.
The Simon Effect Under Reversed Visual Feedbacks
Authors: Sabek Hamza , Heurley Loïc P. , Guerineau Ronan , DRU Vincent 
Published: September 2023

Abstract
Our aim was to study the processes involved in the spatial coding of the body during actions eliciting multiple effects simultaneously. We specifically aim to challenge the intentional-based account, which proposes that the effects used to code responses are those deemed relevant to the agent's goal. Accordingly, we used a Simon task, which is widely recognized as a suitable method for investigating the spatial coding of responses, combined with a setup inducing a multimodal discrepancy between visual and tactile/proprioceptive effects, known to be crucial for body schema construction and action control. To be more precise, the setup allowed to horizontally reverse the visual effects of the hands compared to the tactile/proprioceptive effects (e.g., the right hand was seen as being on the left). In Experiment 1, the participants' task emphasizing the relevance of visual effects, whereas in Experiment 2 it emphasized the tactile/proprioceptive effects. In Experiment 3, the visual effects were no longer reversed. We observed a Simon effect based on the location of the tactile/proprioceptive effects in Experiments 2 and 3. However, in Experiment 1 the Simon effect was partially driven by the location of the visual effects. Altogether, these findings provide support for the notion that the intention of the agent plays a prominent role in the representation of the body during action. This work also opens a promising avenue of research linking action and body representations.
On-surface synthesis of a radical 2D supramolecular organic framework
Authors: Sanchez-Grande Ana , Frezza Federico , Matěj Adam , Carrera Manuel , Mutombo Pingo , Kumar Manish , Curiel David , Jelinek Pavel 
Published: September 2023

Abstract
The design of supramolecular organic radical cages and frameworks is one of the main challenges in supramolecular chemistry. Their interesting material properties and wide applications make them very promising for (photo)redox catalysis, sensors, or host-guest spin-spin interactions. However, the high reactivity of radical organic systems makes the design of such supramolecular radical assemblies challenging. Here, we report the on-surface synthesis of a purely organic supramolecular radical framework on Au(111). We combine supramolecular and on-surface chemistry to obtain a two-dimensional hydrogen-bonded organic radical framework on Au(111). We employ a tripodal precursor, functionalized with 7-azaindole groups that, catalyzed by a single gold atom on the surface, forms a radical molecular product constituted by a π-extended fluoradene-based radical core. The radical products self-assemble through hydrogen bonding, leading to extended 2D domains ordered in a Kagome lattice. This approach demonstrates the potential of on-surface synthesis for developing 2D-supramolecular radical organic chemistry.
Barriers and facilitators of optimal HIV care among prisoners in South Ethiopia: an exploratory study
Authors: Fuge Terefe Gone , Tsourtos George , Miller Emma R 
Published: September 2023

Abstract
Background
Optimal care is crucial for ensuring both therapeutic and preventative benefits of antiretroviral therapy (ART). Sub-optimal care use is common in prisoners and little information is available about its predisposing circumstances in resource-limited settings. We explored barriers to and facilitators of HIV care use amongst inmates living with HIV (ILWH) in South Ethiopia with the aim of suggesting contextually tailored solutions that help ensure universal access to care.
Methods
We conducted qualitative in-depth interviewing with eleven ILWH and eleven service providers. Audio recorded interview data were transcribed verbatim in Amharic language, translated into English and coded based on emerging themes. A phenomenological approach was employed to abstract meaning attributed to the prisoners’ lived experiences in relation to HIV care use and service providers’ experiential account regarding care provision.
Findings
Several themes emerged as barriers to HIV care use amongst ILWH in South Ethiopia including: limited access to standard care, insufficient health staff support, uncooperative security system, loss of patient privacy, a lack of status disclosure due to social stigma, and food supply insufficiency. In addition to a unique opportunity offered by an imprisonment for some ILWH to refrain from health damaging behaviours, the presence of social support in the prison system facilitated care use.
Conclusions
This study identified important structural, social and personal contexts that can both hinder and enhance HIV care use amongst ILWH in South Ethiopia. Given the disproportionate burden of HIV in prisoners and the potential of transmission to others during and after incarceration, development of contextually responsive strategies is required to address the barriers and to also strengthen the enablers.
Efficient Modeling of Quasi-Periodic Data with Seasonal Gaussian Process
Authors: Zhang Ziang , Brown Patrick , Stafford James 
Published: September 2023

Abstract

Quasi-periodicity refers to a pattern in a function where it appears periodic but has evolving amplitudes over time. This is often the case in practical settings such as the modeling of case counts of infectious disease or the population dynamics of species over time. In this paper, we introduce a class of Gaussian processes, called seasonal Gaussian Processes (sGP), for model-based inference of such quasi-periodic behavior. We illustrate that the exact sGP can be efficiently fit in O(n) time using its state space representation for equally spaced locations. However, for large datasets with irregular spacing, the exact approach becomes computationally inefficient and unstable. To address this, we develop a continuous finite dimensional approximation for sGP using the seasonal B-spline (sB-spline) basis constructed by damping B-splines with sinusoidal functions. We prove that the proposed approximation converges in distribution to the true sGP as the number of basis functions increases, and show its superior approximation quality through numerical studies. We also provide a unified and interpretable way to define priors for the sGP, based on the notion of predictive standard deviation (PSD). Finally, we implement the proposed inference method on several real data examples to illustrate its practical usage.
Impact Of Anakinra Use On Clinical Outcomes In Children With Moderate Or Severe Multisystem Inflammatory Syndrome In Children: A Propensity Score Matched Retrospective Cohort Study
Authors: Akkoyun Esra Betul , Most Zachary , Katragadda Harita , Yu Andrew , Nassi Lorien , Oakman Nicole , Ginsburg Sarah , Maamari Mia 
Published: September 2023

Abstract
Background
The treatment of children with multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2 infection involves immunomodulatory therapies such as IVIG and steroids. Anakinra, an interleukin-1 receptor inhibitor, has also been used, but its effectiveness is not established yet. As optimal regimens for MIS-C remain unknown, we aimed to assess the effect of anakinra in reducing hospital stay in patients with MIS-C.
Methods
We included children admitted from May 2020 to May 2021 diagnosed with MIS-C based on CDC criteria. The exposure of interest was anakinra use at any point during admission. The anakinra exposed group and the anakinra unexposed group were propensity score matched based on demographic and clinical severity indicators at initial presentation. Our primary outcome was length of hospital stay. Secondary outcomes were duration of vasoactive support, vasoactive inotropic score (VIS), level of respiratory support, time to fever resolution, reduction of CRP levels, and length of ICU stay. We used Wilcoxon rank sum, t-test, Chi square and Fisher’s exact tests.
Results
Of 138 children diagnosed with MIS-C, 79% had moderate or severe illness and 52% received anakinra. Of those, 31 patients who received anakinra were propensity score matched to 31 who did not. Length of stay in the hospital but not in the ICU was longer in the anakinra group. There were no differences in median duration of vasoactive support, fever resolution, CRP reduction, or VIS.
Conclusions
In patients with MIS-C, use of anakinra was associated with longer duration of hospital stay.