bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Anti‐CCAR1 Autoantibodies With Decreased Cancer Risk Relative to the General Population in Patients With Anti–Transcriptional Intermediary Factor 1γ–Positive Dermatomyositis
Authors: Fiorentino David , Mecoli Christopher A. , Igusa Tak , Albayda Jemima , Paik Julie J. , Tiniakou Eleni , Adler Brittany , Mammen Andrew L. , Shah Ami A. , Rosen Antony , Christopher‐Stine Lisa , Casciola‐Rosen Livia 
Published: February 2023

ObjectiveTo describe the disease specificity, clinical phenotype, and risk of cancer in dermatomyositis (DM) patients with autoantibodies against cell division cycle and apoptosis regulator protein 1 (anti‐CCAR1).MethodsThe frequency of anti‐CCAR1 autoantibodies was measured by enzyme‐linked immunosorbent assay in the serum of DM patients from 2 independent cohorts (Johns Hopkins and Stanford), with patients with several other rheumatic diseases and healthy controls used as comparators. Clinical features and the risk of cancer incidence relative to that in the general population were determined in anti‐CCAR1–positive DM patients.ResultsAnti‐CCAR1 antibodies were significantly associated with anti–transcriptional intermediary factor 1γ (anti‐TIF1γ) antibodies present in the serum of patients with DM: 80 (32%) of 252 anti‐TIF1γ–positive DM patients versus 14 (8%) of 186 anti‐TIF1γ–negative DM patients were positive for anti‐CCAR1 antibodies (P < 0.001). Anti‐CCAR1 antibodies were not detected in any of the 32 serum samples from healthy controls, and were present at very low frequencies in the sera of patients with other rheumatic diseases: 1 (2.3%) of 44 patients with anti–hydroxymethylglutaryl‐coenzyme A reductase–positive necrotizing myopathy, 1 (2.3%) of 44 patients with inclusion body myositis, and 3 (6.5%) of 46 patients with systemic lupus erythematosus were positive for anti‐CCAR1 antibodies. Upon examining data on occurrence of cancer from the onset of DM onward, the observed number of cancers diagnosed in anti–TIF‐1γ–positive DM patients was significantly greater than expected in both cohorts, with a standardized incidence ratio (SIR) of 3.49 (95% confidence interval [95% CI] 2.39–4.92) in the Johns Hopkins cohort and a SIR of 4.54 (95% CI 3.04–6.52) in the Stanford cohort (each P < 0.001). DM patients who were both anti‐TIF1γ positive and anti‐CCAR1 positive had lower SIRs for cancer, with a SIR of 1.78 (95% CI 0.77–3.51) (P = 0.172) in the Johns Hopkins cohort and a SIR of 1.61 (95% CI 0.44–4.13) (P = 0.48) in the Stanford cohort.ConclusionAnti‐CCAR1 autoantibodies are specific for anti‐TIF1γ–positive DM. Their presence in anti‐TIF1γ–positive patients attenuates the risk of cancer to a level comparable to that seen in the general population.image
Low‐Molecular‐Weight J‐Aggregate Solid Red Emitter for Selective and Quantitative Detection of Cyanide
Authors: Padghan Sachin D. , Hu Jiun‐Wei , Wang Li‐Ching , Wang Fang‐Yu , Chen Kew‐Yu 
Published: February 2023

AbstractA dimethylaniline (donor)‐indanedione (acceptor) conjugate (sensor 1) with a very low molecular weight of 277 g mol−1 and intramolecular charge transfer (ICT) characteristics was synthesized. Sensor 1 shows weak ICT fluorescence in solution, but strong emission (Φ=16%) in the solid state owing to intramolecular and intermolecular C−H⋅⋅⋅O hydrogen bonds that inhibit the free rotation of the exocyclic C−C single bond. Compared to yellow emitter 1Y, which has a similar donor‐acceptor structure, sensor 1 shows red fluorescence in the solid state owing to J‐aggregate formation. The colorimetric and fluorometric responses of sensor 1 to cyanide in both solution and solid state are due to the nucleophilic addition of cyanide to the β‐conjugated carbon of the indanedione group, which prohibits ICT. Additionally, inexpensive portable paper‐based test kits based on sensor 1 were easily prepared and could be used for fast and quantitative naked‐eye cyanide detection in real time.
Is the course of the cervicofacial division of the facial nerve consistent with the adjacent vessels?
Authors: Poutoglidis Alexandros , Paraskevas George K. , Anastasopoulos Nikolaos , Asouhidou Irene , Karamitsou Paraskevi , Forozidou Evropi , Lazaridis Nikolaos 
Published: February 2023

AbstractIndividual facial nerve branching patterns can be difficult to predict. The superficial course of its terminal branches poses them at risk of injury during head and neck surgeries. We report the rare course of a branch of the facial nerve deep into the posterior facial vein.
Correlation of the Vector Gradient of a Magnetic Field with the Kinetic Energy of Hard Magnetic Milling Beads in Electromechanical Mills
Authors: Kazak Oleg , Halbedel Bernd 
Published: February 2023

AbstractThis paper describes the experimental investigation and numerical simulation of a novel electromechanical milling principle: the direct transformation of energy into the movement of milling beads with special magnetic properties. The experimental results show that this principle is ideally suited for the finest grinding of organic agents. Anthraquinone particles with a median size of 25.5 µm were electromechanically ground to 1 µm and the magnetic field strength in the process chamber has the greatest influence on milling results. The developed model reveals that the distribution of the time‐ and location‐dependent vector gradient of the magnetic field in the process chamber determines the energy transfer from the exciter systems to the milling beads and hence the grinding results. With a suitable characterization of the vector gradient distribution, it is possible to establish a correlation between the vector gradient and specific milling beads power. This correlation is fundamental for the design of electromechanical milling machines.
A highly selective carbon paste electrode enhanced by Cu‐encapsulated poly(amidoamine) for the simultaneous detection of organic and inorganic contaminants
Authors: Noor Navid , Pajootan Elmira , Mirzaei Parisa , Bahrami S. Hajir 
Published: February 2023

AbstractIn this study, a copper/poly(amidoamine)/multi‐walled carbon nanotube/reduced graphene oxide (Cu/PAMAM/MWCNT/rGO) complex was synthesized for fabricating an electrochemical sensor to simultaneously detect nitrate and nitrite ions as inorganic contaminants, and 4‐chlorophenol (4‐CP) and 1,2,5,8 tetrahydroxy anthraquinone (THA) as organic pollutants. The prepared Cu/PAMAM/MWCNT/rGO electrode was characterized using scanning electron microscopy (SEM), Fourier‐transform infrared (FT‐IR), X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), and electrochemical impedance spectroscopy (EIS). Cyclic voltammetry (CV) was performed to investigate the influence of the pH of the solution, concentration of anions, and scan rate on the analytical performance of the electrodes. The simultaneous determination of nitrite/nitrate ions using a Cu/PAMAM/MWCNT/rGO electrode showed sensitivities of 8.030 × 10−3 and 5.370 × 10−3 μA μM−1 mm−2, and limits of detection (LODs) of 0.081 and 0.115 μM, respectively. For the simultaneous determination of 4‐CP/THA, the sensitivities of the modified electrode were 0.0105 and 9.399 × 10−3 μA μM−1 mm−2, and detection limits were 0.062 and 0.070 μM respectively.
Emergence of Dielectric Properties by Doping of Semi‐Transition Metal in Semiconductor Complex Perovskite Oxide
Authors: Rai Vishnu Shankar , Prajapati Dinesh , Verma Manish Kumar , Kumar Vinod , Kumar Atendra , Das Tapas , Sahoo Kedar , Singh Narsingh Bahadur , Mandal Kamdeo 
Published: February 2023

AbstractThe effect of zinc substitution at the Cu2+ site and germanium substitution at the Ti4+ site in bismuth copper titanate, Bi2/3Cu3Ti4O12, is investigated. Composition with x = 0.05 is synthesized by semi‐wet route in the system Bi2/3Cu3Ti4−xGexO12 (BCTGO) and Bi2/3Cu3−xZnxTi4−xGexO12 (BCZTGO) that are sintered at 1123 K for 8 h. Crystal structure has remained cubic. The phase formations of these ceramics are confirmed by the X‐ray diffraction. The microstructural analysis of the samples is done by scanning electron microscopy and tunneling electron microscopy. Elemental analysis is performed by energy dispersive X‐ray spectroscopy. X‐ray photoelectron spectroscopy suggests that all elements present in these ceramics are in proper oxidation states. The dielectric constant is found high for BCTGO‐0.05 ceramic. The specific capacitances of BCTGO‐0.05 and BCZTGO‐0.05 are found to be 13.05 and 15.7 F g−1, respectively. Optical band gap values (Eg) of BCTGO‐0.05 and BCZTGO‐0.05 ceramics are found as 1.77 and 1.91 eV.
Investigation of in vitro generated metabolites of GLPG0492 using equine liver microsomes for doping control
Authors: Karatt Tajudheen K. , Sathiq M. Anwar , Laya Saraswathy , Philip Moses , Karakka Kal Abdul Khader , Subhahar Michael Benedict 
Published: February 2023

AbstractAn effective alternative to testosterone therapy is selective androgen receptor modulators, a class of compounds that has a tissue‐specific effect on muscle and bone. These drugs, which enhance performance, pose a severe abuse risk in competitive sports. GLPG0492 is one of the selective androgen receptor modulators discovered in recent decades. This compound has a unique tissue‐specific action for muscle and bone against steroid receptors and acts as a partial agonist for androgen receptors. This study examined GLPG0492 and its metabolites in vitro using equine liver microsomes. Liquid chromatography–high‐resolution mass spectrometry was utilized to determine the probable structures of detected metabolites. This study identified 39 metabolites of GLPG0492 (21 phase I and 18 phase II). The hydroxylation of GLPG0492 results in monohydroxylated and dihydroxylated metabolites. Additionally, the study detected dissociated side chains (3‐methyl and 4‐(hydroxymethyl)) and corresponding hydroxylated metabolites. A series of glucuronic acid‐ and sulfonic acid‐conjugated analogs of GLPG0492 were detected during phase II of the study. The findings might help in the detection of GLPG0492 and the elucidation of its illegal use in equestrian sports.
Sandwiched cathodes kinetically boosted by few‐layered catalytic 1T‐MoSe2 nanosheets for high‐rate and long‐cycling lithium‐sulfur batteries
Authors: Xu Jun , Tang Heng , Cao Shoufu , Chen Xiaoyi , Chen Zhao , Ma Yuanming , Zhang Yan , Chen Junwei , Lu Xiaoqing , Lee Chun‐Sing 
Published: February 2023

AbstractAn advanced electrocatalyst to accelerate the sluggish kinetics of multistep redox reactions and suppress the severe shuttle effects is desirable in Li‐S batteries (LSBs). Phase engineering can provide a fascinating way to modulate electronic structures and boost catalytic activity of electrocatalysts. In this study, few‐layered 1T‐MoSe2 nanosheets grown on carbon cloth (1T‐MoSe2/CC) are synthesized and employed as a multifunctional interlayer as well as a catalytic 3D current collector in LSBs to promote both physiochemical confinement and catalytic conversion toward lithium polysulfides (LiPSs). Density functional theory (DFT) calculations reveal that 1T‐MoSe2 has metallic properties beneficial for rapid electronic transport and exhibits a superior catalytic activity to reduce the Gibbs free energy barriers toward LiPS conversion. Significant improvements in chemisorption toward LiPSs, diffusion coefficients of Li ions, and Li2S deposition/decomposition reaction kinetics are realized by the 1T‐MoSe2/CC film. Consequently, the Al@S/AB@1T‐MoSe2/CC LSB, where 1T‐MoSe2/CC is used an interlayer, presents high rate capability of 1253 (1C), 1052 (2C) and 882 (4C) mAh g−1 and excellent long‐term cycling stability at a high rate (2000 cycles at 4C) with a low capacity fading rate (0.017% per cycle). Moreover, with a sandwiched cathode of 1T‐MoSe2/CC@S/AB@1T‐MoSe2/CC, where 1T‐MoSe2/CC works as both a catalytic 3D current collector and a multifunctional interlayer, the LSB at high S loading of 5.7 mg cm−2 and low electrolyte/sulfur ratio of 7.8 μL mg−1 exhibits a high initial areal capacity of 5.43 mAh cm−2 and remarkable rate‐cycling performance (200 cycles).image
Self‐reported expertise and confidence in diagnosing and treating avoidant restrictive food intake disorder among Swedish clinicians
Authors: Dinkler Lisa , Hedlund Elin , Bulik Cynthia M. 
Published: February 2023

AbstractObjectiveTo assess self‐reported knowledge and confidence regarding avoidant restrictive food intake disorder (ARFID) diagnosis and treatment in Swedish clinicians from various disciplines.MethodThe study included 489 clinicians who attended educational lectures about ARFID. Participants responded to 20 ARFID‐related questions and statements using the online audience engagement platform Mentimeter. Items assessed ARFID‐related knowledge, education, and experience, as well as treatment methods offered to ARFID patients at clinicians' healthcare units.ResultsWe found predominantly correct responses to three basic knowledge‐based items about ARFID. However, most participants (64.0%) reported never having received education about ARFID, and few participants reported feeling confident in their ability to diagnose (13.4%) and treat (10.7%) ARFID. Nearly half the sample reported either not knowing which ARFID treatments their unit offered (22.3%) or that no treatment was offered (21.3%).ConclusionExperience and confidence in diagnosing and treating ARFID are generally low in Swedish clinicians, and many individuals with ARFID do not receive treatment. We identify a pressing need for resources, clearer organisation, and structure, and for additional education and training opportunities for clinicians meeting individuals with ARFID.
Study on stress evolution law of upper coal seam in long‐distance advance mining of lower coal seam
Authors: Fang Shengjie , Liang Bing , Sun Weiji , Qin Maolong , Shi Zhanshan , Hao Jianfeng 
Published: February 2023

AbstractWith the shift of coal resources to deep mining, the occurrence of long‐distance coal seams has increased, and protective layer mining is facing new challenges. This paper attempts to explain the stress evolution law of the upper coal group in the long‐distance mining of the lower coal group in Pingdingshan No. 8 Coal Mine. A simulation model of advance mining of lower‐group coal long‐distance was established. The stress evolution law of the upper coal seam under the influence of advanced mining disturbance of the lower coal seam is studied. The following conclusions were obtained: The advance mining of the lower coal group had a positive or negative impact on the stress distribution of the upper coal seam group. With the recovery of the lower coal group of the F‐21030 working face, the overburden of the F‐21030 goaf finally formed a “Y” type pressure relief area. The pressure relief effect of the E‐21070 working face near the stopping line was obvious. The coal seam of Group E was divided into three areas affected by the advance mining of the lower coal seam. The maximum pressure relief value was 6.6% lower than the initial stress. According to the simulation results, the E‐21070 working face was divided into three regions, namely, the pressure relief region, the stress increase region, and the original stress region. According to the field drainage results of pressure relief gas, the extraction curve could be divided into three parts, namely, the stable area, pressure relief area, and stress recovery area. The maximum pure gas drainage volume could reach seven to eight times of the original area. The pressure relief extraction effect was remarkable, and the optimal extraction range was 22–210 m behind the coal face of the group.
Breaking law of overlying strata in shallow coal seam fire area under thermal–mechanical coupling effect
Authors: Zhu Hongqing , Gao Rongxiang , Hu Lintao , Qu Baolin , Liao Qi , Wang Haoran , Fu Mingfu 
Published: February 2023

AbstractThe cracks formed by the breaking and collapse of the overlying strata are the oxygen supply channels for the continuous combustion of coal fires. The development of cracks is of great significance for determining the scope of the fire area and controlling the fire efficiently and accurately. To study the development law of cracks, a breaking model of the overlying strata in the shallow coal seam fire area is established on the basis of beam theory considering the coupling effect of gravity load and temperature field. The physical model of the coal fire is established based on the similarity principle. The temperature data from rock strata in the model are monitored by the infrared thermal imager. The dynamic distribution function of the roof temperature field is obtained by fitting. According to the breaking model theory, the position of the maximum tensile stress on the roof of the shallow fire area is the middle of the lower surface. The theoretical calculation value of the first breaking distance of the roof is 0.575 m, which is consistent with the experimental results of the physical model. The maximum tensile stress of the roof under the thermal‐mechanical coupling is slightly less than that under the load only. For shallow coal seams, the thermal stress generated by the coal fire increases the first breaking distance of the roof.
4‐PBA inhibits hypoxia‐induced lipolysis in rat adipose tissue and lipid accumulation in the liver through regulating ER stress
Authors: Xiong Yanlei , Wang Yueming , Xiong Yanlian , Teng Lianghong 
Published: February 2023

AbstractHigh‐altitude hypoxia may disturb the metabolic modulation and function of both adipose tissue and liver. The endoplasmic reticulum (ER) is a crucial organelle in lipid metabolism and ER stress is closely correlated with lipid metabolism dysfunction. The aim of this study is to elucidate whether the inhibition of ER stress could alleviate hypoxia‐induced white adipose tissue (WAT) lipolysis and liver lipid accumulation‐mediated hepatic injury. A rat model of high‐altitude hypoxia (5500 m) was established using hypobaric chamber. The response of ER stress and lipolysis‐related pathways were analyzed in WAT under hypoxia exposure with or without 4‐phenylbutyric acid (PBA) treatment. Liver lipid accumulation, liver injury, and apoptosis were evaluated. Hypoxia evoked significant ER stress in WAT, evidenced by increased GRP78, CHOP, and phosphorylation of IRE1α, PERK. Moreover, Lipolysis in perirenal WAT significantly increased under hypoxia, accompanied with increased phosphorylation of hormone‐sensitive lipase (HSL) and perilipin. Treatment with 4‐PBA, inhibitor of ER stress, effectively attenuated hypoxia‐induced lipolysis via cAMP‐PKA‐HSL/perilipin pathway. In addition, 4‐PBA treatment significantly inhibited the increase in fatty acid transporters (CD36, FABP1, FABP4) and ameliorated liver FFA accumulation. 4‐PBA treatment significantly attenuated liver injury and apoptosis, which is likely resulting from decreased liver lipid accumulation. Our results highlight the importance of ER stress in hypoxia‐induced WAT lipolysis and liver lipid accumulation.
Effects of the dipeptides comprising leucine and lysine on lifespan and age‐related stress in Caenorhabditis elegans
Authors: Yokoyama Issei , Setoyama Ou , Jia Yaqi , Fujita Nana , Waki Akane , Komiya Yusuke , Nagasao Jun , Arihara Keizo 
Published: February 2023

AbstractThe aging process is affected by various stressors. An increase in oxidative stress is related to the impairment of physiological functions and enhancement of glycative stress. Food‐derived bioactive peptides have various physiological functions, including antioxidant activities. Dipeptides comprising Leu and Lys (LK and KL, respectively) have been isolated from foods; however, their physiological properties remain unclear. In this study, we investigated the antioxidant/antiglycation activity of dipeptides and their antiaging effects using Caenorhabditis elegans (C. elegans). Both dipeptides showed antioxidant activities against several reactive oxygen species (ROS) in vitro. In particular, the scavenging activity of LK against superoxide radicals was higher than KL did. Moreover, dipeptides suppressed advanced glycation end products (AGEs) formation in the BSA–glucose model. In the lifespan assays using wild‐type C. elegans, both LK and KL significantly prolonged the mean lifespan by 20.9% and 11.7%, respectively. In addition, LK decreased intracellular ROS and superoxide radical levels in C. elegans. Blue autofluorescence, an indicator of glycation in C. elegans with age, was also suppressed by LK. These results suggest that dipeptides, notably LK, show an antiaging effect by suppressing oxidative and glycative stress. Our findings suggest that such dipeptides can be used as a novel functional food ingredient. Food‐derived dipeptide Leu–Lys (LK) and Lys–Leu (KL) exert antioxidant and antiglycation activity in vitro. Treatment with LK prolonged the mean lifespan and maximum lifespan of C. elegans more than that of KL. Intracellular ROS and blue autofluorescence levels (indicator of aging) were suppressed by LK.
Computational constraints on the associative recall of spatial scenes
Authors: Ryom Kwang Il , Stendardi Debora , Ciaramelli Elisa , Treves Alessandro 
Published: February 2023

AbstractWe consider a model of associative storage and retrieval of compositional memories in an extended cortical network. Our model network is comprised of Potts units, which represent patches of cortex, interacting through long‐range connections. The critical assumption is that a memory, for example of a spatial view, is composed of a limited number of items, each of which has a pre‐established representation: storing a new memory only involves acquiring the connections, if novel, among the participating items. The model is shown to have a much lower storage capacity than when it stores simple unitary representations. It is also shown that an input from the hippocampus facilitates associative retrieval. When it is absent, it is advantageous to cue rare rather than frequent items. The implications of these results for emerging trends in empirical research are discussed.
Layer‐specific mitochondrial diversity across hippocampal CA2 dendrites
Authors: Pannoni Katy E. , Gil Daniela , Cawley Mikel L. , Alsalman Mayd M. , Campbell Logan A. , Farris Shannon 
Published: February 2023

AbstractCA2 is an understudied subregion of the hippocampus that is critical for social memory. Previous studies identified multiple components of the mitochondrial calcium uniporter (MCU) complex as selectively enriched in CA2. The MCU complex regulates calcium entry into mitochondria, which in turn regulates mitochondrial transport and localization to active synapses. We found that MCU is strikingly enriched in CA2 distal apical dendrites, precisely where CA2 neurons receive entorhinal cortical input carrying social information. Furthermore, MCU‐enriched mitochondria in CA2 distal dendrites are larger compared to mitochondria in CA2 proximal apical dendrites and neighboring CA1 apical dendrites, which was confirmed in CA2 with genetically labeled mitochondria and electron microscopy. MCU overexpression in neighboring CA1 led to a preferential localization of MCU in the proximal dendrites of CA1 compared to the distal dendrites, an effect not seen in CA2. Our findings demonstrate that mitochondria are molecularly and structurally diverse across hippocampal cell types and circuits, and suggest that MCU can be differentially localized within dendrites, possibly to meet local energy demands.