bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aberrant morphological brain networks in first-episode, treatment-naive adolescents with major depressive disorder
Authors: Qiu Xiaofan , Li Junle , Pan Fen , Yang Yuping , Zhou Weihua , Chen Jinkai , Wei Ning , Lu Shaojia , Weng Xuchu , Huang Manli , Wang Jinhui 
Published: April 2023

Abstract
Previous studies have shown that major depressive disorder (MDD) is associated with disrupted topological organizations of large-scale brain networks. However, the disruptions and their clinical and cognitive relevance are not well established for morphological brain networks in adolescent MDD. In this study, twenty-five first-episode, treatment-naive adolescents with MDD and nineteen healthy controls underwent T1-weighted MRI and a battery of neuropsychological tests. Individual morphological brain networks were constructed separately based on 4 morphological features, whose topological organizations were quantified by graph-based approaches. Permutation testing and partial correlation were used to examine between-group differences and clinical and cognitive relevance of the differences, respectively. Finally, support vector machine was used to classify the patients from controls. Compared with the controls, the patients exhibited topological alterations mainly in cortical thickness-based networks characterized by higher nodal centralities in parietal (left PriMary Sensory Cortex) but lower centralities in temporal (left ParaBelt Complex, right Perirhinal Ectorhinal Cortex, right Area PHT and right Ventral Visual Complex) regions. Moreover, decreased nodal centralities of some temporal regions were correlated with cognitive dysfunction and course of illness of the patients. These results were largely reproducible for binary and weighted network analyses. Finally, topological properties of the cortical thickness-based networks were able to distinguish the patients from controls with 87.6% accuracy. In short, adolescent MDD is associated with abnormal local organizations of morphological brain networks, which provide potential biomarkers for diagnosing and monitoring the disease.
The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model
Authors: Jiang Jian , Chang Jinlong , Wang Dilong , Yang Xiuyan , Zhu Wenhui , Yao Peijia , Jiang Youheng , Song Kun , Chang Shuwen , Zhang Xue-Song , Li Huiliang , Li Ningning 
Published: April 2023

Abstract
Background
Microdeletion of the 16p11.2 region of the human chromosome is a prevalent genetic factor for autism spectrum disorder (ASD) and other neurodevelopmental disorders, but its pathogenic mechanism remains unclear, and effective treatments for 16p11.2 microdeletion syndrome are lacking. Emerging evidence suggests that the gut microbiota and its metabolites are inextricably linked to host behavior through the gut-brain axis, and are therefore implicated in ASD development. However, the functional roles of microbial metabolites in the context of 16p11.2 microdeletion are yet to be elucidated. This study aims to investigate the therapeutic potential of indole-3-propionic acid (IPA), a gut microbiota metabolite, in addressing behavioral and pathological deficits associated with 16p11.2 microdeletion, as well as the underlying molecular mechanisms.
Results
Mice with the 16p11.2 microdeletion (16p11.2+/−) showed dysbiosis of the gut microbiota and a significant decrease in IPA levels in feces and blood circulation. Further, these mice exhibited significant social and cognitive impairments, and abnormal activation of hippocampal dentate gyrus neurons, which was accompanied by an imbalance of inhibitory synaptic transmission in this region. However, oral supplementation of IPA significantly mitigated these alterations, thereby ameliorating the social and cognitive deficits of the mice. Remarkably, IPA administration significantly increased the phosphorylation level of ERK1, a protein encoded by the Mapk3 gene in the 16p11.2 region, without affecting the transcription and translation of the Mapk3 gene.
Conclusions
Our study reveal that 16p11.2+/− leads to a decline in gut metabolite IPA levels, and that supplementation with IPA can reverse the associated histological and electrophysiological changes and behavioral defects in 16p11.2+/− mice. These findings provide new insights into the critical role of gut microbial metabolites in ASD pathogenesis and presents a promising treatment treatment strategy for social and cognitive deficit disorders, such as 16p11.2 microdeletion syndrome.
Biodegradable PLA-based materials modified by hemp extract
Authors: Tutek Karol , Masek A.M. 
Published: April 2023

Abstract
Biodegradable and compostable polymers are sensitive to environmental factors. For this reason, they require stabilisers that inhibit ageing and degradation processes. Until now, synthetic stabilisers have been used in the polymer industry, but in recent years, in the era of environmentally friendly solutions, naturally occurring compounds have started to be used. It has become increasingly popular to create composites that are entirely of natural origin. An example of a natural stabiliser is hemp extract, which is presented and studied in this paper. It was applied to a polymer matrix made of polylactide. The samples were subjected to weathering and thermo-oxidative ageing, followed by infrared spectroscopic, spectrophotometric, static-mechanical and surface-free energy analyses. The results obtained confirm the validity of the assumption of an inhibitory ageing effect of hemp extract in the case of thermo-oxidative ageing and, very interestingly, of a catalytic effect in the case of weathering. Research on the use of this type of stabiliser in polymer composites is a scientific novelty that no one has investigated in polymer materials to date. This topic needs to be explored further due to the increasing interest and importance of hemp and its derivatives as materials and functional substances.
Environmental Kuznets Curve Hypothesis in Ethiopia: Is Environmental Development a Priority Over Economic Development for Ethiopia?
Authors: Derege Alemayehu Ethiopia , Alemu Seboka 
Published: April 2023

Abstract
This study used regional panel data from Ethiopia to examine the degree to which Ethiopia adhere to the environmental Kuznets curve hypothesis and, in turn, estimate the extent to which its people are willing to contribute to environmental development. According to the research, the country complies with the environmental Kuznets curve hypothesis; yet, in the short run, people cannot afford to pay more for environmental development. Compared to less urbanized places, those who live in more urbanized states are more prepared to pay for a cleaner environment. The study concludes that economic development takes precedence over environmental development and suggests pro-growth economic policies supported by environmental-focused foreign development assistance.
Assessment, Sizing, and Economic Evaluation of a CCHP Plan for an Office Facility
Authors: Sedighi Mohammad , Ayoobi Ahmadreza , Farmani Mohammad , Sattari Amir Mohammad 
Published: April 2023

Abstract
Due to its potential for greater thermal efficiency compared to standalone power production systems, Combined Cooling, Heating and Power (CCHP) systems have drawn significant attention over the past few decades. The primary goal of this investigation is to provide insights on implementing a CCHP system in an Iranian office building. Choosing the right amount of equipment capacity is one of the most important factors in achieving this goal. Regarding to this, various scenarios and alternatives are introduced based on the gas turbine capacity. The optimal alternative is determined based on a technical and economic analysis, regarding the availability of each alternative. In the end, a study is conducted and pertinent data are provided on decreasing pollutant emissions owing to the implementation of a CCHP system in this office building. In light of Iran's present energy situation, it's important to design the prime mover's optimal capacity so that its electricity generating capacities (based on peak load) are in line with the building's electric demand. In addition, this office building's natural gas and residential electricity usage have an estimated annual impact on the surrounding neighborhood of $80,000.
Comprehensive analysis reveals RANBP17 as a potential biomarker for prognosis and immunotherapy in glioblastoma
Authors: Tang Hai , Liu Xuemei , Li Huahan , Huang Huacong , Ran Chao , Wen Baoying , Liu Qundi , Lu Huaisun , Jing Meilian , Zhou Lingqi 
Published: April 2023

Abstract
Objective: RAN binding protein 17 (RANBP17) gene is a member of the nuclear transport receptor imoprtin family, and have a close relation to the tumorigenesis. However, the role and mechanism of RANBP17 in glioblastoma (GBM) remains unclear. Here, we comprehensively explored the expression, prognostic value, epigenetic modification, immune filtration, tumor stemness, tumor heterogeneity, upstream miRNA and biological function of RANBP17 in GBM combined bioinformatics analysis with functional experiments in vitro.
Methods: The expression of RANBP17 mRNA in GBM was analyzed by TIMER, UALCAN and CCGA databases. The prognostic value of RANBP17 was conducted by LinkedOmics, PrognoScan, and CGGA databases. Mutation status and type of RANBP17 was investigated by cBioportal database and COSMIC database, respectively. The RNA modification and DNA methylation of RANBP17 were analyzed by SangerBox and MethSurv databases. The relationships between RANBP17 expression and tumor heterogeneity, tumor stemness, and tumor immunity in human cancers were analyzed via the SangerBox, TISIDB and TIMER databases. Genes related to RANBP17 were screened by Linkedomics database, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were analyzed by DAVID and STRING database, and the protein-protein interaction (PPI) network was constructed by Cytoscape software. Furthermore, miRWalk, ENCORI and miRDB database was used to predict upstream miRNA of RANBP17. Moreover, the counting kit 8 (CCK-8) assay, flow cytometry, and transwell assays were conducted to evaluate the impact of RANBP17 on the proliferation, apoptosis, migration and invasion in U251 cell.
Results: The expression of RANBP17 was downregulated and related to IDH mutation status, MGMT methylation status and 1p19q codeletion in GBM, which was associated with poor prognosis. RANBP17 was closely related to mRNA methylation genes, tumor heterogeneity and tumor stemness. GO and KEGG enrichment analysis indicated that RANBP17 was involved in neutrophil degranulation, response to estradiol and inflammatory response. Furthermore, the expression of RANBP17 was negatively correlated with B cell, CD4+ T cell, Macrophage, Neutrophil and dendritic cell, and positively correlated with tumor purity and CD8+ T cell. RANBP17 was also associated with hsa-miR-650, hsa-miR-361-5p, hsa-miR-421, hsa-miR-9-5p, hsa-miR-3612, hsa-miR-299-5p, hsa-miR-2115-3p and hsa-miR-19b-3p. Moreover, cell functional experiments in vitro demonstrated that overexpression of RANBP17 decreased cell proliferation, migration, invasion and facilitated apoptosis in GBM.
Conclusions: These findings revealed that RANBP17 was anticipated to be a promising prognostic and immunotherapeutic biomarker in GBM.
Augmented Reality and Ontology-based Approach for Enhancing Arabic Text Recognition and Visualization
Authors: OUALI Imene , HALIMA Mohamed BEN , MASMOUDI Nesrine , AYADI Manel , ALMUQREN Latifa , WALI Ali 
Published: April 2023

Abstract
Written text is a commonly used means of transferring information in our daily lives, and it is especially crucial in unfamiliar environments where we rely on written text to achieve our goals. In such scenarios, signs or signboards help us navigate and determine the direction we should take. However, various factors, such as prolonged exposure to the text, text obstructions, and poor lighting, may hinder our ability to read the text accurately, leading to erroneous readings. A single incorrectly read letter can lead to a false interpretation of the entire text, potentially resulting in serious consequences. To address this issue, we propose an approach to correct letter imperfections in a word and display it in an improved manner. Our approach consists of two phases: the pre-treatment phase and the letter imperfection recovery phase. The pre-treatment phase relies on Augmented Reality technology to detect and recognize text with letter imperfections. In the letter imperfection recovery phase, we employ ontology and a database to correct the letter imperfections. To enhance the accuracy of our results, we apply Augmented Reality technology to obtain a 3D image for perfect visualization. We conducted an evaluation and experimentation phase by administering a questionnaire to a group of participants to obtain feedback on our approach. The results were encouraging and demonstrated the effectiveness of our approach.
Beyond the surgical margin: Patterns of recurrence in WHO grade II intracranial meningiomas
Authors: Obiri-Yeboah Derrick , Soni Pranay , Oyem Precious C. , Almeida João Paulo , Murayi Roger , Recinos Pablo F. , Kshettry Varun R. 
Published: April 2023

Abstract
Purpose
To characterize and classify the location of recurrence in surgically resected World Health Organization (WHO) grade II intracranial meningiomas that did not receive adjuvant radiation, and compare the recurrence pattern of those that underwent gross total (GTR) versus subtotal resection (STR).
Methods
A retrospective review of patients who underwent surgical resection of WHO grade II meningiomas at our institution between 2006 and 2019 was performed. Patients that were observed postoperatively without adjuvant radiation and subsequently developed a recurrence were included. Recurrence was defined as evidence of radiographic progression on postoperative surveillance MRI. Location of recurrence were categorized as: (1)central - growth observed inside the area of the previously resected tumor more than 1 cm inside the original tumor margin; (2)marginal - growth observed within 1 cm (inside or outside) of the original tumor margin; and (3)distant - growth observed more than 1 cm outside of the original tumor margin.
Results
A total of 22 patients matched the inclusion criteria. Twelve (55%) underwent GTR while ten (45%) underwent STR. Of the GTR patients, ten (83.3%) had central recurrence, 11 (91.7%) had marginal recurrence, and only 4 (33.3%) had distant recurrence. Of the STR patients, 9 (90.0%) had central recurrence, all 10 (100.0%) had marginal recurrence, and only 4 (40.0%) had distant recurrence.
Conclusion
The present study evaluating patterns of recurrence for WHO grade II meningiomas after surgical resection showed that recurrence occurred centrally and/or at the original tumor margin, with only a minority recurring > 1cm outside the original tumor margin.
Novel Bayesian Procrustes Variance-based Analysisin Geometric Morphometrics (Part 1)
Authors: CHATTERJEE DEBASHIS 
Published: April 2023

Abstract
Procrustes shape analysis is an essential sub-discipline under Geometric Morphometrics. Compared to classical statistics-based literature, very little Bayesian literature exists for any sub-discipline of Geometric Morphometrics. This paper takes a novel Bayesian approach for considerable advantages of Bayesian over classical. This paper presents a novel Bayesian Procrustes shape analysis methodology for shape parameter distributions (part 1: 2D landmark data & isotropic variance assumption of landmark data). Here we consider the posterior of Procrustes shape variance as morphological variability indicators, which is on par with various laws of mathematical population genetics like Hardy-Weinberg law (Stern, 1943; Masel, 2012). The proposed Bayesian approach does not require any PCA (Principal component analysis) type approximations. This paper also proposes novel Bayesian statistical tests for model validation of new species discovery using morphological variation reflected in the posterior distribution of landmark-variance objects studied under Geometric Morphometrics. We applied our proposed Bayesian Procrustes Analysis on “apes” data of O’Higgins and Dryden (1993). We compared the posterior variance of the shape of females vs. males for each of the Gorillas, chimpanzees, and orangutans. The statistical conclusion favors the novel hypothesis on face shape: “male primate manifests more fluctuation in face shape than females,” which suggests further research in the future.
All the computations and R code done in this paper are organized into a novel, simple R package BPviGM1 (”Bayesian Procrustes Variance-based inferences in Geometric Morphometrics 1”) kept in Github, which essentially contains the R code implementations of the computations for proposed models and methodologies.
Enantioselective Chan-Lam S-Arylation of Sulfenamides
Authors: liang qingjin , Zhang Xinping , Rotella Madeline E. , Xu Zeyu , Kozlowski Marisa C. , Jia Tiezheng 
Published: April 2023

Abstract
Chan-Lam coupling constructs C-N, C-O and C-S bonds by coupling nucleophiles with boronic acids using copper complexes. Such methods benefit from inexpensive and sustainable catalysts, simple and mild reaction conditions, and the potential to generate products with structural diversity. However, control of the stereochemistry in this textbook transformation has proven to be a formidable challenge. We report a highly chemoselective and enantioselective Chan-Lam S-arylation of sulfenamides with arylboronic acids to deliver an array of thermodynamically disfavored diaryl sulfilimines containing a sulfur stereocenter, a class of chiral molecules of great value in chemistry and biology that were synthetically intractable previously. A combined experimental and computational study establishes the reaction mechanism and unveils the origin of chemoselectivity and stereoselectivity.
Revisiting the Obturator Nerve Anatomy with a Nerve Blocking Perspective
Authors: Koç Turan , Beger Orhan , Rumeli Şebnem , Örs Alev Bobuş , Öztürk Nail Can 
Published: April 2023

Abstract
Purpose: Proper nerve blocking is significant for the success of locally anesthetized assisted surgeries. Dis-acknowledging the anatomical variations of targeted nerve anatomy can be problematic for the success of anesthetic fundamentals. Considering the diverse nature of obturator nerve (ON), blockage of ON (ONB) during clinical procedures can be counted within such problematic. Current focus is to revisit the ON anatomy via exemplifying at adult cadavers and fetuses, and then intensively discuss its relevance to ONB from an anatomical perspective.
Methods: ON and its branches were exposed at the posterior wall of the abdomen, lateral wall of the lesser pelvis and anterior aspect of the thigh region in 47 fetuses and 10 adult cadavers. Thereafter, several anatomical motifs and morphometric of ON were meticulously assessed and measured.
Results: Presence of anterior branches (AB) / posterior branches (PB) divergence in the obturator channel and extra-pelvic territory were detected as 40 and 60% respectively, while intra-pelvic occurrence wasn’t observed among the adult cadavers. In fetuses, regional distribution of ON divergence was scattered as 8.5% intra-pelvic, 33% in the channel and 58.5% distal to the channel. Concerning the muscular branching of ON, three fully traceable branching from AB and single one from PB were evident in all the adult cadavers. Significant morphometric distances were also provided in detail.
Conclusion Our discussion regarding the variable motifs of ON anatomy from a nerve-blocking window, covering the results of the current and just few existed anatomical data sets might be helpful for anesthesiologists to improving the success of ONB.
Molybdenite-bearing vugs in microgranite in the Preissac pluton, Québec, Canada: Relicts of aqueous fluid pockets?
Authors: Mulja Thomas , Williams-Jones Anthony E. 
Published: April 2023

Abstract
Field, petrochemical, and stable isotope data from peraluminous microgranite dikes and their molybdenite-bearing vugs in the Archean Preissac-Lacorne batholith, Québec, provide evidence for the transport and deposition of molybdenum by an aqueous fluid that exsolved from a felsic magma. A model is proposed in which the microgranite-forming liquid fractionated from a magma that was parental to and intruded less-evolved muscovite monzogranite. Fluid saturation is interpreted to have occurred immediately prior to emplacement, allowing sufficient time for small spherical pockets of fluid to form and rise through the liquid but insufficient time for them to leave the system. These fluid pockets scavenged molybdenum and other components during their migration but were frozen in situ to form molybdenite-bearing vugs as a result of the quenching of the magma. We therefore conclude that the vugs are relicts of the exsolved fluid pockets and that the molybdenite in them reflects the concentration of molybdenum in the fluid, estimated from volumetric relationships to have reached ~7800 ppm.
Tool Box for Product Safety: Modern Chromatography and Mass Spectrometry
Authors: Dai Susie Y. 
Published: April 2023

Modern chromatography coupled with mass spectrometry is a powerful analytical tool to analyze and characterize regulated products based on the physical separation through chromatography and atomic/molecular characterization of the separated analytes. Gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) are particularly applicable to the measurement of complex mixtures, assisted with proper pre-sample treatment. Particularly, LC-MS can be used as a screening, confirmation, and quantification tool for hundreds, or even thousands, of chemical components of the target matrices in one analysis. Advantages of LC-MS over other techniques, such as many traditional wet chemistry and biochemistry methods (i.e. gravimetric analysis, volumetric analysis) include selectivity, sensitivity, and high throughput. This issue in Journal of Regulatory Science focuses on several studies examining nutritional components and contaminants in food and dietary supplements. Liquid chromatography and mass spectrometry platforms have discovered the new applications in product safety testing, averting from the traditional medical and pharmaceutical field.https://doi.org/10.21423/jrs-v03n02pi (DOI assigned 8/7/2019)
Experimental investigation and modelling of rainfall-induced erosion of semi-arid region soil under various vegetative land covers
Authors: Al Balasmeh Odai , Karmaker Tapas , Babbar Richa 
Published: April 2023

Abstract

Laboratory-scale experiments were conducted to investigate the impact of three different vegetative covers (khus, dry leaves, and wheat straw) on soil erosion and runoff under four different surface slopes and two different types of soils. Results were compared with experiments for bare soil under similar conditions for three major parameters: surface runoff, sub-surface flow, and soil loss. It was found that wheat straw reduced the surface runoff from 60 ml/s (for bare soil) to 20 ml/s, while with leaves and khus, it was 40 ml/s. Wheat straw cover increased the infiltration by 60% and reduced soil loss by 85% compared to bare soil. The findings were validated with the HYDRUS-1D simulations for infiltration and surface runoff in bare soil under similar experimental conditions. Experimental findings were found to agree well with the model simulations. The present study can be treated as a nature-based solution to soil erosion, groundwater recharge, and delayed surface runoff in semi-arid regions.