bluuebunny/crossref_metadata_2025_split huggingface dataset:
IAN: Iterated Adaptive Neighborhoods for Manifold Learning and Dimensionality Estimation
Authors: Dyballa Luciano , Zucker Steven W. 
Published: February 2023

AbstractInvoking the manifold assumption in machine learning requires knowledge of the manifold's geometry and dimension, and theory dictates how many samples are required. However, in most applications, the data are limited, sampling may not be uniform, and the manifold's properties are unknown; this implies that neighborhoods must adapt to the local structure. We introduce an algorithm for inferring adaptive neighborhoods for data given by a similarity kernel. Starting with a locally conservative neighborhood (Gabriel) graph, we sparsify it iteratively according to a weighted counterpart. In each step, a linear program yields minimal neighborhoods globally, and a volumetric statistic reveals neighbor outliers likely to violate manifold geometry. We apply our adaptive neighborhoods to nonlinear dimensionality reduction, geodesic computation, and dimension estimation. A comparison against standard algorithms using, for example, k-nearest neighbors, demonstrates the usefulness of our approach.
Correlations between DKI and DWI with Ki-67 in gastric adenocarcinoma
Authors: Yuan Letian , Lin Xiangtao , Zhao Peng , Ma Hui , Duan Shuai , Sun Shanshan 
Published: February 2023

Background Diffusion kurtosis imaging (DKI) has been applied for gastric adenocarcinoma. Correlations between its parameters and Ki-67 are unclear. Purpose To investigate the correlation between DKI and diffusion-weighted imaging (DWI) parameters with the Ki-67 index in gastric adenocarcinoma. Material and Methods A total of 54 patients with gastric adenocarcinoma were enrolled in the study and underwent DWI and DKI at 3.0-T MRI before surgery. Based on the settings of the regions of interest, the DWI and DKI parameters (including apparent diffusion coefficient [ADC], diffusion kurtosis [K], and diffusion coefficient [DK]) of each patient's gastric adenocarcinoma were measured and calculated. The participants were divided into two groups (low Ki-67 group and high Ki-67 groups). The intraclass correlation coefficient (ICC) and independent-sample t-test were used to compare differences in each parameter between two groups. Spearman's correlation coefficient was calculated to determine the correlation between Ki-67 and the parameters. Each parameter was compared using the area under the receiver operating characteristic curve. All parameters were included in the multivariate logistic regression analysis to explore the relationship between each parameter and high Ki-67 index. Results ADC and DK were negatively relevant with Ki-67 and K was positively relevant with Ki-67 in gastric adenocarcinoma. ADC, DK, and K had diagnostic efficiency in differentiating the low Ki-67 group from the high Ki-67 group. A higher K value independently predicted a high Ki-67 status. Conclusion DWI and DKI reflected the proliferative characteristics of gastric adenocarcinoma. K was the strongest independent factor for predicting high Ki-67 status.
Differences of injury characteristics of medial patellofemoral ligament in acute lateral patellar dislocation and multiligament knee injuries
Authors: Zheng Lei , Zhang Meng , Si Xiao-lin , Zhang Guang-ying 
Published: February 2023

Background The injury characteristics of medial patellofemoral ligament (MPFL) in multiligament knee injuries (MLKIs) and the differences of injury patterns of MPFL in MLKIs and acute lateral patellar dislocation (LPD) remain unclear. Purpose To explore the differences of injury characteristics of MPFL after acute LPD and MLKIs. Methods Magnetic resonance images were prospectively analyzed in 219 patients after acute LPD or MLKIs. Statistical analyses of the injury patterns of MPFL were performed between LPD and MLKIs. Results The incidence of partial tear and complete MPFL tear in adolescent LPD and MLKIs were 40.3% and 48.4%, and 27.9% and 16.3%, respectively. Compared with LPD, MLKIs showed lower incidence rates of partial and complete MPFL tears (both P = 0). The MLKI subgroup showed lower incidence rates of MPFL tear at the patellar insertion (PAT), femoral attachment (FEM), and multiple-site of the MPFL (COM) (9.3%, 20.9%, and 14%) when compared with the LPD subgroup (45.2%, 24.2%, and 16.1%) (all P < 0.01). The incidence of partial tear and complete MPFL tear in adult LPD and MLKIs were 41.5% and 47.2%, and 24.6% and 16.4%, respectively. Compared with LPD, MLKIs showed lower incidence rates of partial and complete MPFL tears (both P = 0). The MLKI subgroup showed lower incidence rates of MPFL tear at PAT, FEM, and COM (8.2%, 18%, and 14.8%) when compared with the LPD subgroup (20.8%, 34%, and 30.2%) (all P = 0). Conclusion Compared with LPD, MPFL tears are relatively uncommon in MLKIs. Even if MPFL tears occur, partial tears and femoral-sided tears are relatively more common.
A Comparison of All-inside and Inside-out Meniscal Repair in Elite Athletes
Authors: Borque Kyle A. , Laughlin Mitzi S. , Webster Emily , Jones Mary , Pinheiro Vítor Hugo , Williams Andy 
Published: February 2023

Background: The popularization of all-inside (AI) meniscal repair devices has led to a shift away from the historical gold standard of inside-out (IO) meniscal repair without comparative studies to support the change. Purpose: To compare the failure rate and time to failure of AI and IO meniscal repair performed in elite athletes. Study Design: Cohort study; Level of evidence, 3. Methods: A retrospective review was performed of all professional and national- and international-level amateur athletes who underwent meniscal repair, with a minimum of 2-year follow-up between January 2013 and September 2019. Meniscal repair was classified as AI or IO depending on the surgical technique performed. Treatment failure was defined as patients having to undergo subsequent surgery to address a persistent meniscal tear after repair. Cox proportional hazards modeling was used to determine if meniscal repair failure rates differed by the location and technique of meniscal repair. Models were controlled for known risk factors such as age, sex, sport, and concurrent cruciate ligament reconstruction. Results: A total of 192 (135 lateral and 57 medial) meniscal repairs were performed in elite athletes during the study period. Overall, 41 (21%) meniscal repairs met the criteria for failure. Medial meniscal tears repaired with the AI technique failed at a significantly higher rate (18/31 [58%]) than medial meniscal tears repaired with the IO technique (6/26 [23%]) or lateral meniscal tears repaired with the AI (9/76 [12%]) or IO (8/59 [14%]) technique ( P < .001). Cox proportional hazards modeling revealed that a medial meniscal tear repaired with the AI technique had an almost 8 times greater hazard of failure than a lateral meniscal tear repaired with the AI technique ( P < .001). At 1 year postoperatively, 8% of lateral meniscal repairs had failed (regardless of technique), while medial meniscal tears failed at a rate of 16% with the IO technique and 42% with the AI technique. By 2 years, 53% of medial meniscal tears repaired with the AI technique had failed, and by 5 years, 63% had failed. Conclusion: AI repair of medial meniscal tears led to a higher rate of failure than IO repair of medial or lateral meniscal tears in elite athletes. Medial meniscal repair failed at a higher rate than lateral meniscal repair.
Sepsis in postcardiotomy cardiogenic shock patients supported with veno- arterial extracorporeal membrane oxygenation
Authors: Tantway Tarek M , Arafat Amr A , Albabtain Monirah A , Belghith Makhlouf , Osman Ahmed A , Aboughanima Mohamed A. , Abdullatif Muhammad T , Elshoura Youssef A. , AlBarak Mohammed M 
Published: February 2023

Background: Sepsis could affect the outcomes of patients with postcardiotomy cardiogenic shock supported with extracorporeal membrane oxygenation (ECMO). Our objectives were to characterize sepsis patients with ECMO support for postcardiotomy cardiogenic shock and assess its predictors and effect on patients’ outcomes. Methods: This retrospective study included 103 patients with ECMO for postcardiotomy cardiogenic shock from 2009 to 2020. Patients were divided according to the occurrence and timing of sepsis into three groups. Group 1 included patients with no sepsis ( n = 67), Group 2 included patients with ECMO-related sepsis ( n = 10), and Group 3 included patients with non-ECMO-related sepsis ( n = 26). Results: Lactate level before ECMO was highest in the ECMO-associated sepsis group (Group 1 and 2 p = 0.003 and Group 2 and 3 p = 0.003). Dialysis and gastrointestinal bleeding were highest in ECMO-associated sepsis ( p = 0.03 and 0.04, respectively). Blood transfusion was higher in ECMO-associated sepsis than in patients with no sepsis ( p = 0.01). Mortality was nonsignificantly higher in patients with ECMO-associated sepsis. High BMI (OR: 1.11; p = 0.004), preoperative dialysis (OR: 7.35; p = 0.02), preoperative IABP (OR: 9.9.61; p = 0.01) and CABG (OR: 6.29; p = 0.01) were significantly associated with sepsis. Older age (OR: 1.08; p = 0.004), lower BSA (OR: 0.004; p = 0.003), peripheral cannulation (OR: 29.82; p = 0.03), and high pre ECMO lactate level (OR: 1.24; p = 0.001) were associated with increased mortality. Sepsis did not predict mortality (OR: 1.83; p = 0.21). Conclusions: Sepsis is a dreaded complication in patients with postcardiotomy cardiogenic shock, especially ECMO-associated sepsis. Preoperative risk factors could predict postoperative sepsis in ECMO patients.
Correlates of Perceived Stress and Professional Quality of Life Among Nurses Working in Neonatal Intensive Care Units (NICU) in North India: A Multicenter Study
Authors: Shivani  , Sharma Mohit , Sonakshi  , Singh Jatinder , Arora Kamaldeep , Kumar Ashwani , Dhir Shashi Kant , Chowdhary Gurdev , Chawla Vani , Rai Harman , Goyal Nikita , Singh Vajinder , Kaur Baljinder , Mehra Keshav , PV Varughese , Kumar Pardeep , Mahal Tania , Bajaj Naveen 
Published: February 2023

Objective To estimate the levels of perceived stress and determine the professional quality of life domains namely, compassion satisfaction, burnout, and secondary trauma and their associated factors in neonatal intensive care unit (NICU) nurses. Methods A multicenter cross-sectional study was carried out across a number of NICUs in North India from May to June 2022. A total of 223 nurses included in the study were given a self-administered questionnaire consisting of their sociodemographic profile, work profile, PSS 14 scale, and ProQol 5 scale. Data was analyzed using descriptive statistics, correlation coefficient, and multiple regression. Results Based on PSS 14, 52(23.3%), 132(59.2%), and 39(17.5%) nurses experienced mild, moderate, and severe stress, respectively. Burnout and secondary trauma were found to be average in the majority of nurses (178[79.8%] and 175 [78.5%], respectively) in regard to professional quality of life domains. A sizable portion of the nurses was found to have average to high compassion satisfaction. Factors such as more number of night duties, alarms and lights in NICU, lesser professional experience, high workload, being unmarried, and having no children were found to be significant in association with perceived stress and professional quality of life. Conclusion According to this study, the majority of nurses who work in NICUs experience moderate levels of stress, which negatively impacts their professional quality of life. Therefore, it is important to consider various stress management programs based on the stressors.
A comparative evaluation of three extended depth of focus intraocular lenses
Authors: Lesieur Gilles , Dupeyre Paul 
Published: February 2023

Purpose To compare the refractive and visual performance of three Extended Depth of Focus (EDOF) intraocular lenses (IOLs) after uncomplicated cataract surgery. Setting Centre IRIDIS, Albi, France. Design Comparative retrospective study. Methods Patients with cataracts and without other eye diseases were enrolled for monocular implantation of EDOF IOLs on the dominated eye by the same surgeon between 2018 and 2021, using either the IsoPure (BVI-PhysIOL, Belgium), the Synthesis+ (Cutting Edge, France), or the Lucidis (SAV-IOL, Swiss). Refraction, Uncorrected Distance Visual Acuity (UDVA), Corrected Distance VA (CDVA), Uncorrected Near VA (UNVA), Distance-Corrected Near VA (DCNVA), 25% Contrast CDVA, and Defocus Curve were assessed 3-months postoperatively. Results A total of 64 eyes of 64 patients were included in this study (IsoPure n = 22; Synthesis+ n = 20, Lucidis n = 22). CDVA, 25% Contrast CDVA and DCNVA were significantly better for Lucidis than IsoPure or Synthesis+. No significant difference was observed for CDVA and 25% Contrast CDVA between IsoPure and Synthesis+. DCNVA was significantly better for Lucidis and Synthesis+ with respectively 0.08 LogMAR ± 0,09 and 0.29 LogMAR ± 0.13, compared to 0.40 LogMAR ± 0.17 for IsoPure ( p < 0.05). Conclusions Lucidis showed more efficient distance, low contrast, and near vision than IsoPure and Synthesis+. Synthesis+ seems to be more efficient in intermediate vision than other groups. Each EDOF IOLs provided good distance vision without creating spontaneous complaints of photic phenomena. Refractive EDOF IOLs, especially Lucidis, are efficient for patients wishing to improve their vision without dysphotopsia.
Child Protection in Indian Programme and Legislative Framework: A Critical Analysis
Authors: Jain Bhavya 
Published: February 2023

The Indian Judicial System lags in addressing child trafficking, as it does not yet have a dedicated Act or law to address the issue of either human or child trafficking. The Trafficking of Persons (Prevention, Protection and Rehabilitation) Bill of 2018 still awaits a nod from the Upper House of the Parliament, the Rajya Sabha, to be implemented. However, a network of other laws, policies and schemes sets out measures to provide some preventive and rehabilitative services for children who are vulnerable to trafficking or have been trafficked. These include children who have lost one or both parents, live on streets, belong to low socio-economic background and have been abused, among others. Some of the laws and policies regarding safeguarding of children include the Juvenile Justice (Care and Protection of Children) Act, 2015; Mission Vatsalya, 2022 and Child and Adolescent Labour (Prohibition and Regulation) Act, 1986. The mentioned laws and policies have set up key mechanisms for child protection by the government in the Indian context. This article looks to identify such provisions across the Indian legislative and programmatic landscape that are instrumental in keeping children in the care of family as far as possible and providing them safe out-of-home care where family care cannot be provided. It also reviews how these provisions set up, or fail to set up, a safety net around children to protect them from trafficking. The article undertakes a critical analysis of child protection measures set up by the government in India to identify good practices as well as gaps in the judicial and policy landscape of child protection and trafficking. It analyses the Guidelines on Mission Vatsalya, Juvenile Justice (Care and Protection of Children) Act, 2015 and Child and Adolescent Labour (Prohibition and Regulation) Act, 1986.
Examining the contribution of motivation in the job search of youth with developmental language disorder
Authors: Dubois Pascale , Guay Frédéric , St-Pierre Marie-Catherine 
Published: February 2023

Background & aims Youth with developmental language disorder (DLD) are at risk of experiencing challenges during their job search. It is thus crucial to promote efficient job search behaviors in terms of effort, intensity, and self-regulation. Based on self-determination theory (SDT), we verified the role of autonomous and controlled motivations in enhancing these behaviors. Methods Study 1 included 37 young adults with DLD who have finished school, and Study 2 included 52 youth with DLD transitioning from school to work. They completed a questionnaire examining their job search behaviors and their motivation toward their job search. Results Autonomous motivation positively predicted job search effort, intensity, and self-regulation. Small to moderate relations were observed in Study 1, and moderate to strong ones in Study 2. Controlled motivation was unrelated to the three behaviors. Conclusions In line with SDT, autonomous motivation is an important foundation for positive job search behaviors among youth with DLD. Implications Supporting the development of autonomous motivation is thus encouraged in transition services for this population.
Preparation and characterization of the myricetin-loaded solid lipid nanoparticles decorated with folic acid-bound chitosan and evaluation of its antitumor and anti-angiogenic activities in vitro and in vivo in mice bearing tumor models
Authors: Khatamian Niloufar , Motavalizadehkakhky Alireza , Homayouni Tabrizi Masoud , Mehrzad Jamshid , Zhiani Rahele 
Published: February 2023

AbstractMyricetin is a flavonoid with anticancer properties. This study aimed to formulate myricetin in the form of solid lipid nanoparticles (SLN), decorated with chitosan (CS) and active-targeted with folic acid (FA). After characterization, the in vitro release, cytotoxicity, antioxidant, and ability of the formulation to induce apoptosis using flow cytometry, fluorescent microscopy, and real-time qPCR were examined. Then in vivo anti-angiogenesis on chick chorioallantoic membrane (CAM) and antitumor activities on mice bearing tumor models were investigated. The present study showed that the size of 310 nm and zeta potential of + 30 mV were acceptable for oral administration. The Michaelis–Menten model fitted the drug release pattern with lag during 144 h of the study. The cytotoxicity assay showed that myricetin-SLN-CS-FA significantly killed cancer cells at the concentrations of 6.25, 12.5, 25, 50 and 100 µg/mL (*p < 0.05, **p < 0.01, and ***p < 0.001). The highest level of apoptosis was shown at the concentration of 45 µg/ml in flow cytometry, and fluorescent studies. These results showed the anticancer properties of myricetin-SLN-CS-FA in a dose-dependent manner. The real-time results also indicated that the formulation exerted its cytotoxic effect by activating apoptosis genes. The DPPH, ABTS, and FRAP studies also demonstrated the significant antioxidant properties of the myricetin-SLN-CS-FA (*p < 0.05, **p < 0.01, and ***p < 0.001). The anti-angiogenic activities of the formulations depicted in the CAM assay significantly decrease the number and length of the vessels (*p < 0.05, **p < 0.01, and ***p < 0.001), and also affect VEGF and VEGFR, genes involved in angiogenesis (**p < 0.01, and ***p < 0.001). The antitumor studies indicated the statistically significant effects of myricetin-SLN-CS-FA on reducing tumor volume (*p < 0.05 and ***p < 0.001). The H&E staining of the liver and monitoring of the animal weights also indicated the safety of the formulation. The analysis of mRNA expression in liver and tumor demonstrated that myricetin-SLN-CS-FA exerts its antitumor activities by modulating the inflammatory and oxidative responses in the tissues.
The dual role of Nrf2 in melanoma: a systematic review
Authors: Malakoutikhah Zahra , Mohajeri Zahra , Dana Nasim , Haghjooy Javanmard Shaghayegh 
Published: February 2023

AbstractMelanoma is the most lethal type of skin cancer that originates from the malignant transformation of melanocytes. Although novel treatments have improved patient survival in melanoma, the overall prognosis remains poor. To improve current therapies and patients outcome, it is necessary to identify the influential elements in the development and progression of melanoma.Due to UV exposure and melanin synthesis, the melanocytic lineage seems to have a higher rate of ROS (reactive oxygen species) formation. Melanoma has been linked to an increased oxidative state, and all facets of melanoma pathophysiology rely on redox biology. Several redox-modulating pathways have arisen to resist oxidative stress. One of which, the Nrf2 (nuclear factor erythroid 2-related factor 2), has been recognized as a master regulator of cellular response to oxidative or electrophilic challenges. The activation of Nrf2 signaling causes a wide range of antioxidant and detoxification enzyme genes to be expressed. As a result, this transcription factor has lately received a lot of interest as a possible cancer treatment target.On the other hand, Nrf2 has been found to have a variety of activities in addition to its antioxidant abilities, constant Nrf2 activation in malignant cells may accelerate metastasis and chemoresistance. Hence, based on the cell type and context, Nrf2 has different roles in either preventing or promoting cancer. In this study, we aimed to systematically review all the studies discussing the function of Nrf2 in melanoma and the factors determining its alteration.
The empirical estimate of the survival and variance using a weighted composite endpoint
Authors: Nabipoor Majid , Westerhout Cynthia M. , Rathwell Sarah , Bakal Jeffrey A. 
Published: February 2023

Abstract
Background
Composite endpoints for estimating treatment efficacy are routinely used in several therapeutic areas and have become complex in the number and types of component outcomes included. It is assumed that its components are of similar asperity and chronology between both treatment arms as well as uniform in magnitude of the treatment effect. However, these assumptions are rarely satisfied. Understanding this heterogeneity is important in developing a meaningful assessment of the treatment effect.

Methods
We developed the Weighted Composite Endpoint (WCE) method which uses weights derived from stakeholder values for each event type in the composite endpoint. The derivation for the product limit estimator and the variance of the estimate are presented. The method was then tested using data simulated from parameters based on a large cardiovascular trial. Variances from the estimated and traditional approach are compared through increasing sample size.

Results
The WCE method used all of the events through follow-up and generated a multiple recurrent event survival. The treatment effect was measured as the difference in mean survivals between two treatment arms and corresponding 95% confidence interval, providing a less conservative estimate of survival and variance, giving a higher survival with a narrower confidence interval compared to the traditional time-to-first-event analysis.

Conclusions
The WCE method embraces the clinical texture of events types by incorporating stakeholder values as well as all events during follow-up. While the effective number of events is lower in the WCE analysis, the reduction in variance enhances the ability to detect a treatment effect in clinical trials.