bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation from above or below: Port greening measures in the European Union and the United States
Authors: DeSombre Elizabeth R. , Knudsen Jette Steen , Elder Molly 
Published: January 2023

AbstractFocusing on 23 greening measures, this paper systematically compares the greening efforts of the busiest container and cargo ports in the United States (US) and the European Union (EU). We move beyond accounts for general environmental differences between the EU and the US to examine how specific environmental decisions are shaped by the effects of regulatory characteristics in each region. We identify systematic variation in number and type of port greening measures adopted in the two regions. We demonstrate that differences in the number and type of measures adopted reflect the level of policy making with local policy making playing a more important role in the US compared to the EU, thus proposing a pathway through which the form of regulatory approach could influence content and extent of regulation. The EU adopts regulation that is broader in scope while US ports are more likely to address problems affecting local populations.
Bounds on the number of rational points of curves in families
Authors: Lemos Pedro , Torzewski Alex 
Published: January 2023

AbstractIn this note, we give an alternative proof of uniform boundedness of the number of integral points of smooth projective curves over a fixed number field with good reduction outside of a fixed set of primes. We use that due to Bertin–Romagny, the Kodaira–Parshin families constructed by Lawrence–Venkatesh can themselves be assembled into a family. We then repeat Lawrence–Venkatesh's study of the ‐adic period map, together with the comparison of nearby fibres.
Long‐diagonal pentagram maps
Authors: Izosimov Anton , Khesin Boris 
Published: January 2023

AbstractThe pentagram map on polygons in the projective plane was introduced by R. Schwartz in 1992 and is by now one of the most popular and classical discrete integrable systems. In the present paper we introduce and prove integrability of long‐diagonal pentagram maps on polygons in , by now the most universal pentagram‐type map encompassing all known integrable cases. We also establish an equivalence of long‐diagonal and bi‐diagonal maps and present a simple self‐contained construction of the Lax form for both. Finally, we prove that the continuous limit of all these maps is equivalent to the ‐KdV equation, generalizing the Boussinesq equation for .
Large-scale submarine landslide drives long-lasting regime shift in slope sediment deposition
Authors: Stagna Marina Dottore , Maselli Vittorio , van Vliet Arjan 
Published: January 2023

Abstract
Submarine landslides and associated mass-transport deposits (MTDs) modify the physiography of continental margins and influence the evolution of submarine sediment routing systems. Previous studies highlighted the control of landslides and MTDs on subsequent sedimentary processes and deposits at spatial scales ranging from tens of centimeters to few kilometers, leaving a knowledge gap on how and for how long large-scale submarine landslides (i.e., headscarps wider than 50–100 km) may affect the stratigraphic evolution of continental margins. To fill this gap, we used three-dimensional seismic reflection data tied to an exploration well to investigate the impact of one of the largest submarine landslides discovered on Earth, the Mafia mega-slide (Mms) offshore Tanzania, on slope sediment deposition. Seismic data interpretation indicates that turbidite lobes/lobe complexes and coalescent mixed turbidite-contourite systems formed the pre-Mms stratigraphy between 38 and ca. 21 Ma (age of the Mms), whereas coarser-grained sheet turbidites and debrites accumulated after the Mms for ∼15 m.y., primarily on the topographic lows generated by the emplacement of the landslide. We interpret this drastic and long-lasting regime shift in sediment deposition to be driven by the increase in seafloor gradient and the capture and focus of feeding systems within the broad failed area. We propose that the extensive evacuation zones associated with such giant landslides can generate major “conveyor belts”, trapping land-derived material or sediments transported by along-slope processes such as bottom currents. During the progressive healing of the landslide escarpments, which may last for several million years, sand-prone facies are deposited primarily in the upper slope, filling up the accommodation space generated by the landslide, while deeper-water environments likely remain sediment starved or experience accumulation of finer-grained deposits. Our study provides new insights into the long-term response of slope depositional systems to large-scale submarine landslides, with implications for the transfer of coarse-grained sediments that can be applied to continental margins worldwide.
Supplemental Material: Compositions and ages of Early Cretaceous volcanic and plutonic rocks in central Tibet: Insights into the magmatic and uplift response to slab breakoff
Authors: Wu Hao , al. et 
Published: January 2023

<p>Table S1: Zircon LA-ICP-MS isotopic data for representative samples from the Duolong igneous association. Table S2: Major- (wt%) and trace-element (ppm) compositions of representative samples from the Duolong igneous association. Table S3: Zircon Hf isotopic data for representative samples from the Duolong igneous association. Table S4: Whole-rock Sr-Nd isotopic compositions of rhyolites from the Duolong igneous association. Table S5: Summary of zircon U-Pb age data for Early Cretaceous magmatic rocks from the Duolong igneous association. </p>
Protocol for an exploratory, randomised, single-blind clinical trial of aerobic exercise to promote remyelination in multiple sclerosis
Authors: Wooliscroft Lindsey , McCoy Sharon , Hildebrand Andrea , Rooney William , Oken Barry S , Spain Rebecca Irene , Kuehl Kerry S , Bourdette Dennis , Cameron Michelle 
Published: January 2023

IntroductionThere is an urgent need for remyelinating therapies that restore function in people with multiple sclerosis (pwMS). Aerobic exercise is a promising remyelinating strategy because it promotes remyelination in animal models both independently and synergistically with medications. Here, in this study, we present an innovative, randomised, single-blind, clinical trial designed to explore: the relationship between demyelination and mobility (part 1), and if 24 weeks of aerobic exercise promotes remyelination in pwMS (part 2).Methods and analysisSedentary participants (n=60; aged 18–64 years) with stable MS will undergo a baseline visit with the following outcomes to assess associations between demyelination and mobility (part 1): spinal cord demyelination (somatosensory-evoked potentials, SSEPs), mobility (6-Minute Timed Walk, Timed 25-Foot Walk, Timed Up and Go, 9-Hole Peg Test) and patient-reported outcomes (PROs). After baseline testing, participants with significantly prolonged SSEP latency will advance to the clinical exercise trial (part 2) and will be randomised 1:1 to active or control conditions for 24 weeks. The active condition will be aerobic stationary cycling three times per week with graded virtual supervision. The control condition will be monthly virtual MS symptom education groups (six sessions). SSEP latency (remyelination endpoint), mobility outcomes and PROs will be measured at 12 and 24 weeks in all clinical trial participants. A subset of 11 active and 11 control participants will undergo a brain MRI with quantitative T1myelin water fraction at baseline and 24 weeks (exploratory remyelination endpoint).Ethics and disseminationEthical approval was obtained from the Oregon Health & Science University Institutional Review Board (#21045). Dissemination of findings will include peer-reviewed publications, conference presentations and media releases. The proposed study will inform the feasibility, study design and sample size for a fully powered clinical trial of aerobic exercise to promote remyelination in pwMS.Trial registration numberNCT04539002.
Knowledge, attitudes and behaviours surrounding preconception and pregnancy health: an Australian cross-sectional survey
Authors: Musgrave Loretta , Homer Caroline , Gordon Adrienne 
Published: January 2023

ObjectiveTo understand Australian women’s knowledge, attitudes and behaviours surrounding preconception and pregnancy health and their preferences for information about these periods.DesignCross-sectional survey.SettingMaking healthy changes can optimise preconception and pregnancy outcomes. Clinical practice guidelines inform preconception and pregnancy care in Australia. Women often have access to multiple sources of information on reproductive and pregnancy health.ParticipantsWomen of reproductive age were asked to complete a web-based survey. The survey development was informed by preconception guidelines, consensus statements and the national pregnancy care guidelines. The survey was distributed through social media, local and national networks from 2017 to 2018.ResultsCompleted surveys were received from 553 women.The majority (80.4%) had high educational attainment. Checking immunisation status and ensuring good mental health were rated as equally important actions both preconception (65%) and during pregnancy (78%). Limiting sedentary activities was not rated as an important action to take either preconception (36%), or during pregnancy (38%). Although women have good knowledge about the impact of weight on their own health outcomes (eg, gestational diabetes), there was less knowledge about adverse outcomes for babies like stillbirth and preterm birth. Women access many sources for reproductive health information, however, the most trusted source was from healthcare professionals.ConclusionMost women of reproductive age in Australia have knowledge of the key health recommendations for preconception and pregnancy. However, there are gaps related to lifestyle behaviours particularly connected to weight gain and outcomes for babies. There is a strong preference to receive trusted information from healthcare providers through multiple resources.
The chiral Lagrangian with three flavors and large-$$N_c$$ sum rules
Authors: Heo Yonggoo , Kobdaj C. , Lutz Matthias F. M. 
Published: January 2023

AbstractWe reconsider the chiral Lagrangian with three-flavor baryon fields. A systematic analysis of all low-energy constants (LEC) that contribute to the axial-vector and pseudoscalar currents in the baryon octet and decuplet fields at next-to-leading order in the inverse number of colors ($$1/N_c$$

1
/

N
c

) of QCD is performed. We study the correlation function consisting of axial-vector and scalar currents as well. While there are 4 LEC relevant at leading chiral order, the number of relevant LEC at subleading order is 23. For those a leading order large-$$N_c$$

N
c

analysis predicts 3 and 18 sum rules respectively. At the next accuracy level the number of sum rules is reduced to 2 and 8. Our results are illustrated by a tree-level analysis of available axial-vector coupling constants and strong decay widths of the baryon decuplet states.
Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study
Authors: Lindley Clara L. , Gigic Biljana , Peoples Anita R. , Han Claire J. , Lin Tengda , Himbert Caroline , Warby Christy A. , Boehm Juergen , Hardikar Sheetal , Ashworth Anjelica , Schneider Martin , Ulrich Alexis , Schrotz-King Petra , Figueiredo Jane C. , Li Christopher I. , Shibata David , Siegel Erin M. , Toriola Adetunji T. , Ulrich Cornelia M. , Syrjala Karen L. , Ose Jennifer 
Published: January 2023

AbstractBackground:Patients with colorectal cancer commonly suffer from complex psychological distress. Elevated distress may be linked to systemic biomarkers. We investigated associations of biomarkers of inflammation and angiogenesis with cancer-related distress (CTXD) score.Methods:N = 315 patients (stage I–IV) from 2 centers of the ColoCare Study were included: Huntsman Cancer Institute and University of Heidelberg. Biomarkers (e.g., IL6, VEGF-A, VEGF-D) were measured in serum collected pre-surgery and 12 months thereafter. The CTXD overall score and 4 subscales were collected 12 months after surgery and dichotomized to investigate biomarkers as predictors of distress 12 months after surgery; adjusted for age, sex, body mass index, tumor stage, center, and baseline levels of biomarkers.Results:Doubling of IL6 predicted future increased risk of overall distress [odds ratio (OR), 1.20; 95% confidence interval (CI), 1.02–1.41; P = 0.03]. VEGF-A–predicted future increased risk of high family strain (VEGF-A: OR, 1.21; 95% CI, 1.01–1.44; P = 0.04) and VEGF-D was associated with medical and financial demands (OR, 1.34; 95% CI, 1.01–1.74; P = 0.03).Conclusions:This is the first study to show that systemic biomarkers are significantly associated with future CTXD score. Distress was not measured at baseline; we cannot rule out ongoing associations of inflammation and distress throughout treatment versus a direct effect of inflammation on distress. Nonetheless, these data add to evidence that biobehavioral processes interact and that systemic biomarkers are associated with cancer-related distress one year after surgery.Impact:Exercise and diet interventions that lower systemic cytokine levels may impact longer-term CTXD score and improve quality of life of patients with colorectal cancer.
Tumor Dynamic Model-Based Decision Support for Phase Ib/II Combination Studies: A Retrospective Assessment Based on Resampling of the Phase III Study IMpower150
Authors: Bruno René , Marchand Mathilde , Yoshida Kenta , Chan Phyllis , Li Haocheng , Zou Wei , Mercier Francois , Chanu Pascal , Wu Benjamin , Lee Anthony , Li Chunze , Jin Jin Y. , Maitland Michael L. , Reck Martin , Socinski Mark A. 
Published: January 2023

Purpose:
Model-based tumor growth inhibition (TGI) metrics are increasingly incorporated into go/no-go decisions in early clinical studies. To apply this methodology to new investigational combinations requires independent evaluation of TGI metrics in recently completed Phase III trials of effective immunotherapy.

Patients and Methods:
Data were extracted from IMpower150, a positive, randomized, Phase III study of first-line therapy in 1,202 patients with non–small cell lung cancer. We resampled baseline characteristics and longitudinal sum of longest diameters of tumor lesions of patients from both arms, atezolizumab+ bevacizumab+chemotherapy (ABCP) versus BCP, to mimic Phase Ib/II studies of 15 to 40 patients/arm with 6 to 24 weeks follow-up. TGI metrics were estimated using a bi-exponential TGI model. Effect sizes were calculated as TGI metrics ratio of medians (MedR), objective response rate (ORR) difference (d), and progression-free survival (PFS), hazard ratio (HR) between arms. Correct and incorrect go decisions were evaluated as the probability to achieve desired effect sizes in ABCP versus BCP and BCP versus BCP, respectively, across 500 replicated subsamples for each design.

Results:
For 40 patients/24 weeks follow-up, correct go decisions based on probability tumor growth rate (KG) MedR &lt;0.90, dORR &gt;0.10, and PFS HR &lt;0.70 were 83%, 69%, and 58% with incorrect go decision rates of 4%, 12%, and 11%, respectively. For other designs, the ranking did not change with TGI metrics consistently overperforming RECIST endpoints. The predicted overall survival (OS) HR was around 0.80 in most of the scenarios investigated.

Conclusions:
Model-based estimate of KG MedR is an exploratory endpoint that informs early clinical decisions for combination studies.
IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLC
Authors: Patel Sonia A. , Nilsson Monique B. , Yang Yan , Le Xiuning , Tran Hai T. , Elamin Yasir Y. , Yu Xiaoxing , Zhang Fahao , Poteete Alissa , Ren Xiaoyang , Shen Li , Wang Jing , Moghaddam Seyed Javad , Cascone Tina , Curran Michael , Gibbons Don L. , Heymach John V. 
Published: January 2023

AbstractPurpose:Patients with advanced non–small cell lung cancer (NSCLC) harboring activating EGFR mutations are initially responsive to tyrosine kinase inhibitors (TKI). However, therapeutic resistance eventually emerges, often via secondary EGFR mutations or EGFR-independent mechanisms such as epithelial-to-mesenchymal transition. Treatment options after EGFR-TKI resistance are limited as anti-PD-1/PD-L1 inhibitors typically display minimal benefit. Given that IL6 is associated with worse outcomes in patients with NSCLC, we investigate whether IL6 in part contributes to this immunosuppressed phenotype.Experimental Design:We utilized a syngeneic genetically engineered mouse model (GEMM) of EGFR-mutant NSCLC to investigate the effects of IL6 on the tumor microenvironment and the combined efficacy of IL6 inhibition and anti-PD-1 therapy. Corresponding in vitro studies used EGFR-mutant human cell lines and clinical specimens.Results:We identified that EGFR-mutant tumors which have oncogene-independent acquired resistance to EGFR-TKIs were more mesenchymal and had markedly enhanced IL6 secretion. In EGFR-mutant GEMMs, IL6 depletion enhanced activation of infiltrating natural killer (NK)- and T-cell subpopulations and decreased immunosuppressive regulatory T and Th17 cell populations. Inhibition of IL6 increased NK- and T cell–mediated killing of human osimertinib-resistant EGFR-mutant NSCLC tumor cells in cell culture. IL6 blockade sensitized EGFR-mutant GEMM tumors to PD-1 inhibitors through an increase in tumor-infiltrating IFNγ+ CD8+ T cells.Conclusions:These data indicate that IL6 is upregulated in EGFR-mutant NSCLC tumors with acquired EGFR-TKI resistance and suppressed T- and NK-cell function. IL6 blockade enhanced antitumor immunity and efficacy of anti-PD-1 therapy warranting future clinical combinatorial investigations.
Investigating Reasons for Disagreement in Natural Language Inference
Authors: Jiang Nan-Jiang , Marneffe Marie-Catherine de 
Published: January 2023

AbstractWe investigate how disagreement in natural language inference (NLI) annotation arises. We developed a taxonomy of disagreement sources with 10 categories spanning 3 high- level classes. We found that some disagreements are due to uncertainty in the sentence meaning, others to annotator biases and task artifacts, leading to different interpretations of the label distribution. We explore two modeling approaches for detecting items with potential disagreement: a 4-way classification with a “Complicated” label in addition to the three standard NLI labels, and a multilabel classification approach. We found that the multilabel classification is more expressive and gives better recall of the possible interpretations in the data.
The Northern Ethiopia Armed Conflict and the Unusual Decline of Grade 12 Students’ Result in Amhara Region
Authors: Belay Degwale Gebeyehu , Ayalew Sisay Tamirat 
Published: January 2023

Abstract
The Secondary School Leaving Examination, which is administered at the completion of grade 12 is the only criterion that determines admittance of students into the University. Students from Amhara Region; who have been under pressure of the Northern Ethiopian Armed Conflict, have scored unusual low entry marks which have yet given acceptable reply. This article aimed at exploring the nature of appeal system in Ethiopia, the issues of accountability and legitimacy of the Ministry of Education. Situational analysis of qualitative research approach is employed in this study. The study found out that there is no clear and trusted appeal system which inclusively and effectively provides response to the complaints. Besides, the ethnic politics of the country sadly spoils the education system and not everyone stands for the right of students, but only those who do have ethnic affiliations.
Alpha-lipoic acid inhibits sodium arsenite-mediated autophagic death of rat insulinoma cells
Authors: Cheng Yong , Yang Xiuli , Tang Wenjuan , Fu Qiong , Li Hong , Liang Bing 
Published: January 2023

Aim To investigate the protective effect of α-lipoic acid on sodium arsenite (NaAsO2) induced INS-1 cells injury and its mechanism. Methods The cell viability was measured by CCK-8 assay. The autophagosomes was observed under transmission electron microscopy. The autophagosomes in cells transfected with green fluorescent protein microtubule-associated protein light chain 3 (GFP-LC3) plasmids were observed under a laser scanning con-focal microscope. The expression of LC3-II, P62, PI3K, and mTOR proteins in INS-1 cells treated with a combination of chloroquine (CQ, autophagy inhibitor) and NaAsO2 were detected by Western blot assay. The expression of LC3-II, P62, PI3K, and mTOR proteins were detected in INS-1 cells treated with a combination of rapamycin (autophagy inducer, mTOR inhibitor) and α-LA. Results The cytotoxicity induced by NaAsO2 was reversed by α-LA, and the viability of NaAsO2-treated INS-1 cells increased. α-LA pretreatment decreased the autophagosome accumulation induced by NaAsO2. α-LA also reduced the fluorescence spot aggregation of GFP-LC3 in INS-1 cells exposed to NaAsO2 as observed under a laser scanning con-focal microscope. α-LA inhibited NaAsO2 induced autophagy by up-regulating PI3K and mTOR and down-regulating LC3-II and P62. CQ inhibited NaAsO2 induced autophagy by up-regulating PI3K, mTOR, P62 and down-regulating LC3-II. α-LA inhibited rapamycin-induced autophagy by up-regulating PI3K, mTOR and P62 and down-regulating LC3-II. The results showed that NaAsO2 could induce autophagy activation in INS-1 cells. The α-LA may inhibit autophagy activation by regulating the PI3K/mTOR pathway. Conclusion The data indicated that α-LA might inhibit the NaAsO2-induced autophagic death of INS-1 cells by regulating the PI3K/mTOR pathway.
A comparison of antiplatelet therapy during the peri- and post-operative periods following flow-diverting stent insertion for unruptured intracranial aneurysms: A systematic review
Authors: Leung Agnes Lorraine , Li Vincent , de Villiers Laetitia , Hattingh Laetitia 
Published: January 2023

Background Flow diverters (FDs) are neuroendovascular stents indicated for the management of unruptured intracranial aneurysms. Due to their composition, dual antiplatelet therapy (DAPT) is essential during the peri- and post-operative periods to prevent thromboembolic events. However, there is limited consensus within the scientific community regarding which antiplatelets to use and dosing following neuroendovascular treatment of aneurysms. Method A systematic search of four electronic databases was conducted during November 2020 that included studies published between January 2010 and November 2020. Eligibility for inclusion included primary research articles, published in the English language and use of flow-diverting intracranial stents. Studies were excluded if they utilised combined therapies (e.g. FD with stent-assisted coiling), animal studies, clinical trial protocols and study population of less than 10 subjects. Results Eighteen studies were identified for inclusion with a total of 1312 patients with 1355 unruptured intracranial aneurysms treated with FDs. Of these, 13 studies primarily investigated the use of clopidogrel with aspirin with low rates of haemorrhagic and thromboembolic complications. A forest plot of nine of these studies showed average efficacy of 88% at 95% confidence interval (CI) (SD + 5%) with 63% heterogeneity. Conclusions The large proportion of studies investigating clopidogrel and aspirin antiplatelet therapy presents a challenge in comparing antiplatelet regimens. Although prasugrel and ticagrelor have been identified as suitable alternatives to clopidogrel, these were based on studies with small cohort sizes. Glycoprotein IIb/IIIa inhibitors may be efficacious as rescue therapy for intra-procedural thrombosis. Further research is required to determine which antiplatelet is most suitable.