bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of a False Inertial Cue in the Velocity-Storage Circuit on Head Posture and Inertia Perception
Authors: Choi Jeong-Yoon , Koo Yu Jin , Song Jung-Mi , Kim Hyo-Jung , Kim Ji-Soo 
Published: January 2023

The velocity-storage circuit participates in the vestibulopostural reflex, but its role in the postural reflex requires further elucidation. The velocity-storage circuit differentiates gravitoinertial information into gravitational and inertial cues using rotational cues. This implies that a false rotational cue can cause an erroneous estimation of gravity and inertial cues. We hypothesized the velocity-storage circuit is a common gateway for all vestibular reflex pathways and tested that hypothesis by measuring the postural and perceptual responses from a false inertial cue estimated in the velocity-storage circuit. Twenty healthy human participants (40.5 ± 8.2 years old, 6 men) underwent two different sessions of earth-vertical axis rotations at 120°/s for 60 s. During each session, the participants were rotated clockwise and then counterclockwise with two different starting head positions (head-down and head-up). During the first (control) session, the participants kept a steady head position at the end of rotation. During the second (test) session, the participants changed their head position at the end of rotation, from head-down to head-up or vice versa. The head position and inertial motion perception at the end of rotation were aligned with the inertia direction anticipated by the velocity-storage model. The participants showed a significant correlation between postural and perceptual responses. The velocity-storage circuit appears to be a shared neural integrator for the vestibulopostural reflex and vestibular perception. Because the postural responses depended on the inertial direction, the postural instability in vestibular disorders may be the consequence of the vestibulopostural reflex responding to centrally estimated false vestibular cues.SIGNIFICANCE STATEMENTThe velocity-storage circuit appears to participate in the vestibulopostural reflex, which stabilizes the head and body position in space. However, it is still unclear whether the velocity-storage circuit for the postural reflex is in common with that involved in eye movement and perception. We evaluated the postural and perceptual responses to a false inertial cue estimated by the velocity-storage circuit. The postural and perceptual responses were consistent with the inertia direction predicted in the velocity-storage model and were correlated closely with each other. These results show that the velocity-storage circuit is a shared neural integrator for vestibular-driven responses and suggest that the vestibulopostural response to a false vestibular cue is the pathomechanism of postural instability clinically observed in vestibular disorders.
Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells
Authors: Cao Leixi , Wang Ruijie , Liu Guangzhi , Zhang Yuwei , Thorne Rick Francis , Zhang Xu Dong , Li Jinming , Xia Yang , Guo Lili , Shao Fengmin , Gu Hao , Wu Mian 
Published: January 2023

AbstractUnveiling the principles governing embryonic stem cell (ESC) differentiation into specific lineages is critical for understanding embryonic development and for stem cell applications in regenerative medicine. Here, we establish an intersection between LIF‐Stat3 signaling that is essential for maintaining murine (m) ESCs pluripotency, and the glycolytic enzyme, the platelet isoform of phosphofructokinase (Pfkp). In the pluripotent state, Stat3 transcriptionally suppresses Pfkp in mESCs while manipulating the cells to lift this repression results in differentiation towards the ectodermal lineage. Pfkp exhibits substrate specificity changes to act as a protein kinase, catalyzing serine phosphorylation of the developmental regulator Lin41. Such phosphorylation stabilizes Lin41 by impeding its autoubiquitination and proteasomal degradation, permitting Lin41‐mediated binding and destabilization of mRNAs encoding ectodermal specification markers to favor the expression of endodermal specification genes. This provides new insights into the wiring of pluripotency‐differentiation circuitry where Pfkp plays a role in germ layer specification during mESC differentiation.
NEDD4L facilitates granulosa cell ferroptosis by promoting GPX4 ubiquitination and degradation
Authors: Tang Hong , Jiang Xiaomei , Hua Yu , Li Heyue , Zhu Chunlan , Hao Xiaobai , Yi Minhui , Li Linxia 
Published: January 2023

Background
Polycystic ovary syndrome (PCOS) is an androgen disorder and ovarian dysfunction disease in women of reproductive age. The cell death of granulosa cells (GCs) plays an important role in the development of PCOS. However, the mechanism of GC death is still unclear.

Methods
In the current study, NEDD4L was found to be elevated in PCOS GEO (Gene Expression Omnibus) databases and mouse models. The cell viability was analyzed by CCK-8 and FDA staining. The expression of ferroptosis markers was assessed by ELISA and immunofluorescence. The direct interaction of GPX4 and NEDD4L was verified by co-immunoprecipitation assay.

Result
Functionally, results from CCK-8 and FDA staining demonstrated that NEDD4L inhibited the cell viability of KGN cells and NEDD4L increased the levels of iron, malonyldialdehyde, and reactive oxygen species and decreased glutathione levels. Moreover, the cell death of KGN induced by NEDD4L was blocked by ferroptosis inhibitor, suggesting that NEDD4L regulates KGN cell ferroptosis. Mechanistically, NEDD4L directly interacts with GPX4 and promotes GPX4 ubiquitination and degradation.

Conclusion
Taken together, our study indicated that NEDD4L facilitates GC ferroptosis by promoting GPX4 ubiquitination and degradation and contributes to the development of PCOS.
Profile of autism spectrum disorders in Morocco: cross-sectional retrospective study of parents of children with autism
Authors: Sefrioui Mohamed Réda , Elidrissi Imane , Sbai El Othmani Ibrahim , Derfoufi Sanae , Ait Haj Said Amal , Benmoussa Adnane , Derraji Soufiane 
Published: January 2023

Context and objective. In Morocco, autism is a frequent disorder and no epidemiological studies have been carried out. The aim of this work is to analyze the characteristics of the onset of autism in children.
Settings and Design. We conducted a cross-sectional retrospective study, spread over a period of 10 months.
Methods. We included in our survey children who, according to the DSM 5 definition, had one of the autism spectrum disorders and had a well-defined diagnosis. For the statistical analysis we used Excel® software. We used the percentages for the description of the qualitative variables.
Results. Of the parents of children with ASD, 49% were biological mothers. Of these, 30% women had their child when they were between 30 and 35 years of age. Males accounted for 61% of children with a sex ratio of 2.6. The first autistic traits appeared at the age of 18 months for 22% of our population. Of mothers with children with ASD, 83% had regular medical follow-up throughout their pregnancy. All autistic children in our population were vaccinated according to the National Immunization Program. According to parent reports, 70% affirmed that the first autistic features appeared after vaccination with the measles-mumps-rubella (MMR) vaccine, knowing that this statement is not based on evidence.
Conclusions. The quality of care depends on the age at which the diagnosis of autism is established.
Genetic and Physiological Effects of Insulin-Like Growth Factor-1 (IGF-1) on Human Urate Homeostasis
Authors: Mandal Asim K. , Leask Megan P. , Sumpter Nicholas A. , Choi Hyon K. , Merriman Tony R. , Mount David B. 
Published: January 2023

Background
Metabolic syndrome and hyperinsulinemia are associated with hyperuricemia. Insulin infusion in healthy volunteers elevates serum urate (SU) by activating net urate reabsorption in the renal proximal tubule, whereas insulin-like growth factor-1 (IGF-1) infusion reduces SU by mechanisms unknown. Variation within the IGF1R gene also affects SU levels.

Methods
Colocalization analyses of a SU genome-wide association studies signal at IGF1R and expression quantitative trait loci signals in cis using COLOC2, RT-PCR, Western blotting, and urate transport assays in transfected HEK 293T cells and in Xenopus laevis oocytes.

Results
Genetic association at IGF1R with SU is stronger in women and is mediated by control of IGF1R expression. Inheritance of the urate-lowering homozygous genotype at the SLC2A9 locus is associated with a differential effect of IGF1R genotype between men and women. IGF-1, through IGF-1R, stimulated urate uptake in human renal proximal tubule epithelial cells and transfected HEK 293T cells, through activation of IRS1, PI3/Akt, MEK/ERK, and p38 MAPK; urate uptake was inhibited in the presence of uricosuric drugs, specific inhibitors of protein tyrosine kinase, PI3 kinase (PI3K), ERK, and p38 MAPK. In X. laevis oocytes expressing ten individual urate transporters, IGF-1 through endogenous IGF-1R stimulated urate transport mediated by GLUT9, OAT1, OAT3, ABCG2, and ABCC4 and inhibited insulin's stimulatory action on GLUT9a and OAT3. IGF-1 significantly activated Akt and ERK. Specific inhibitors of PI3K, ERK, and PKC significantly affected IGF-1 stimulation of urate transport in oocytes.

Conclusions
The combined results of infusion, genetics, and transport experiments suggest that IGF-1 reduces SU by activating urate secretory transporters and inhibiting insulin's action.
Síntesis y caracterización de NiMo5W/Al2O3 modificado con ZnO para la hidrodesnitrogenación de Indol
Authors: Puello Polo Esneyder , Muñoz Montes Yeiny Johana , Caro Candezano Miguel Antonio 
Published: January 2023

Objetivo: En este estudio se evaluó el efecto de la modificación con óxido de zinc del soporte convencional en catalizadores de hidrodesulfuración (HDS) a base polioxometalato Anderson-Evans de NiMo5W. Metodología: Los catalizadores fueron sintetizados por el método de co-precipitación del polioxometalato Anderson-Evans de NiMo5W sobre Al2O3. Los catalizadores se caracterizaron por FRX, MEB/EDS, CHONS, propiedades texturales, FT-IR, Raman y titulación potenciométrica con n-butilamina. Resultados: La MEB reveló tamaños de agregados de partículas para NiMo5W/γ-Al2O3 entre 0,7 μm y 4,1 μm, y para NiMo5W/γ-Al2O3-ZnO entre 0,5 μm y 3,5 μm. Las isotermas fueron de tipo IV característica de materiales mesoporosos, sus áreas específicas fueron γ-Al2O3 (207 m2/g), γ-Al2O3-ZnO (185 m2/g), NiMo5W/γ-Al2O3 (97 m2/g) y NiMo5W/γ-Al2O3-ZnO (121 m2/g). FTIR demostró que la inclusión de ZnO en el soporte promueve una mejor adsorción del polioxometalato en la superficie. Raman de los catalizadores solo mostró modos característicos del MoS2 A1g: (378 cm-1) y (404 cm-1). La titulación potenciométrica con n-butilamina indicó mayor densidad de sitios ácidos para NiMo5W/γ-Al2O3 (20,6 μmol/m2) frente a NiMo5W/γ-Al2O3-ZnO (15,2 μmol/m2). El catalizador NiMo5W/γ-Al2O3-ZnO (95%/67%) presentó mayor conversión de indol e HDN que NiMo5W/γ-Al2O3 (85%/55%). Conclusiones: La reacción de hidrodesnitrogenación de Indol siguió el mecanismo de reacción reportado en la literatura. La reacción de hidrodesnitrogenación de Indol siguió el mecanismo de reacción reportado en la literatura. De ahí que, el catalizador NiMo5W/γ-Al2O3-ZnO (95%/67%) presentó mayor conversión de indol e HDN que NiMo5W/γ-Al2O3 (85%/55%).
SOBRE LA ENSEÑANZA DEL INGLÉS EN LA CARRERA DE EDUCACIÓN FÍSICA
Authors: Moreno Luis Guillermo 
Published: January 2023

Durante los últimos años en Colombia como reflejo de los movimientos académicos a Nivel Internacional, se ha venido cuestionando la enseñanza de los idiomas en las distintas carreras universitarias y es claro que existe la necesidad primero por parte del estudiante del conocimiento de una segunda lengua que le permita ampliar su campo de investigaciones y luego por parte del profesorado de idiomas de estructurar o mejor reestructurar un programa para estos idiomas de tal manera que no entren a llenar un horario sino que de verdad cumplan un papel importante en la formación del futuro profesional.
APRENDIZAJE Y ENSEÑANZA EN LA EDUCACIÓN FÍSICA DE PRIMARIA Y SECUNDARIA
Authors: Samulski Dietmar 
Published: January 2023

De acuerdo al currículo, ya en la primaria la Educación Física es un campo indepen-diente. el cual tiene tareas con objetivos es-pecíficos de aprendizaje (p.e.: estado atlético, hab ilidades) y con contenid os espec¡ficos de aprendizaje (p.e.: clases de deporte tales como la natación. atletismo y los juegos). De acuerdo a los nuevos conceptos, se debe considerar en la formación de la clase, el aumento de los objetivos de aprendizaje. especialmente los de tipo social y cognoscitivo. Debido a ésto. ganan en importancia los componentes de la psicología y psicología social.
Editorial
Authors: Gómez Valenzuela Juan David 
Published: January 2023

El camino continúa, la discusión propuesta en esta publicación se materializa hoy con aportes de diversos académicos que se pronuncian desde diferentes latitudes. Entregamos a la comunidad académica regional, nacional e internacional ocho artículos que tocan diversos tópicos: el desempeño motor deportivo, la investigación en la formación inicial, el desarrollo académico e investigativo, el uso del medio ambiente en la escuela, el para qué del juego en la escolaridad y en la calle, y la constitución de subjetividad.
Manejo del dolor de espalda a través del movimiento consiente, estudio de caso.
Authors: Castro Carvajal Julia , Uribe Rodríguez Marta , Zapata Restrepo Patricia 
Published: January 2023

Se explora desde una postura fenomenológica que guía la descripción, las manifestaciones y cambios en la conciencia somática de una mujer participante de un programa de educación somática brindado a un grupo de quince trabajadores de la Universidad de Antioquia como alternativa educativa en salud ocupacional, en el cual se desarrollo un entrenamiento dirigido a ampliar el rango de conocimiento sonsoriomotriz a través del movimiento consciente, con el fin de favorecer la autorregulación y el acto cuidado
Exposiciones realizadas
Authors: Moncada Roldan Arturo 
Published: January 2023

Exposiciones realizadas • Primera exposición de pintura de empleados de Cadenalco realizada en Medellín en octubre de 1984. • Exposición individual en la Universidad San Buenaventura de Medellín en octubre de 1984. • Finalista en el VIII Concurso de Fotografía realizado por el Departamento de Cultura y Biblio­tecas de Comfenalco – Antioquia, julio del 1997 • Como participante estuvo en el Concurso de Fotografía de la Escuela Nacional Sindical realizado en Medellín en 2002 y 2004. • Entre 1993 y 1998, me desempeñé como asistente de fotografía de Alejandro Manosalva. Fotó­grafo publicitario.
Características antropométricas, composición corporal, somatotipo y rendimiento anaeróbico y aeróbico de mujeres juveniles baloncestistas chilenas
Authors: García Guajardo Vicente , De Arruda Miguel , Aránguiz Aburto Hugo , Rojas Díaz Sergio , García Krauss Paula 
Published: January 2023

El objetivo del estudio fue describir y comparar las características antropométricas, la composición corporal, el somatotipo y el rendimiento de las variables anaeróbicas y aeróbicas de un grupo de mujeres juveniles baloncestistas chilenas en función a la posición de juego. Fueron evaluadas 16 atletas juveniles con una media de 16,9±1,3 años, donde fueron medidas 10 variables antropométricas con el propósito de determinar la composición corporal y el somatotipo, así como los niveles de saltabilidad (Squat Jump, Counter Movement Jump, Saltos 15s, Abalakow), velocidad 20 m., distancia de 0-5m y el componente aeróbico mediante la predicción del VO2max. Para el análisis estadístico se utilizó la estadística descriptiva de media aritmética, desviación estándar y para verificar las diferencias significativas entre las posiciones de juego se aplicó ANOVA y la prueba de especificidad (P<0,001).
Los resultados muestran diferencias significativas (p
Bullying Depicted in Cyberbully Movie
Authors: Kamilah Fitriah Nur , Amelia Firqo , Wardhani Dwi Taurina Mila 
Published: January 2023

This research identified types of bullying and impacts of bullying in Cyberbully movie. The design of this study is qualitative. The method is used to describe and analyze bullying in movie Cyberbully. The data collection was done by watching Cyberbully movie, screen capturing the scenes, and writing down the utterances indicating both the types and impact of bullying. The data analysis was done by classifying the types of bullying in Cyberbully movie by using the theory National Centre against Bullying (2010), finding the impact of bullying in Cyberbully movie by using the theory of Rigby (2003). The finding of the research found that there were twenty data for three types of bullying on the main character in movie Cyberbullying: Verbal bullying, Social bullying ,and Cyberbullying. Here the researchers also managed to find twenty-four data for the impact of bullying which consists of three types, namely: low psychological well-being, poor social adjustment, and psychological distress.
ANALISIS MARKETING SYARIAH TERHADAP STRATEGI PEMASARAN KERIPIK TEMPE DE YATI MADIUN
Authors: Rizki Utami  , Unun Roudlotul Janah  
Published: January 2023

This study will discuss the effect of financial performance on stock returns of mining companies that go public on the Indonesian stock exchange. This study uses secondary data. The population in this study are mining companies listed on the Indonesia Stock Exchange, and the year of the study was from 2013 to 2015. In this study, 3 independent variables with 2 control variables and one dependent variable were used. The data analysis used is Descriptive Statistics, Classical Assumption Test, and Multiple Linear Regression. While the hypothesis testing used in this study using the Feasibility Test Model (F) and Hypothesis Testing (t). The results showed that Earning Per Share (EPS) and Price Book Value (PBV) had a positive effect on stock returns. While the Debt to Equity Ratio (DER) has a negative effect on stock returns in mining companies listed on the Indonesia Stock Exchange.
Abstrak
Penelitian ini akan membahas pengaruh kinerja keuangan terhadap return saham perusahaan pertambangan go public di bursa efek indonesia. Penelitian ini menggunakan data sekunder dengan Populasi dalam penelitian ini yaitu perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia, dan tahun penelitian nya adalah pada 2013 sampai tahun 2015. Dalam penelitian ini menggunakan 3 variabel independen dengan 2 variabel kontrol dan satu variabel dependen. Analisis data yang digunakan adalah Statistik Deskriptif, Uji Asumsi Klasik, dan Regresi Linear Berganda. Sedangkan Pengujian hipotesis yang digunakan dalam penelitian ini menggunakan Uji Kelayakan Model (F) dan Uji Hipotesis (t). Hasil penelitian menunjukkan bahwa Earning Per Share (EPS) dan Price Book Value (PBV) pengaruh positif terhadap return saham. Sedangkan Debt to Equity Ratio (DER) berpengaruh negatif terhadap return saham pada perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia.
A Systematic Review of Clinical Epidemiology and Outcomes of Emergency Department-Acute Kidney Injury Found High Incidence and Poor Outcomes
Authors: Cheung Tsz Yan , Lam Kelvin , Leung Siu Chung , Rainer Timothy H 
Published: January 2023

Abstract

Background: Over half of all community-acquired acute kidney injury (CA-AKI) initially presented to the emergency department (ED), but ED-AKI is poorly characterised, poorly understood, often under-recognised and under-managed. There is no systematic review focusing on ED-AKI. Yet, in-hospital AKI deaths are often associated with suboptimal recognition, management, and documentation.
Therefore, we aim to systematically review the incidence, risk factors, and outcomes of emergency department acute kidney injury (ED-AKI), and risk factors of post-ED-AKI mortality globally.
Methods: We included published prospective or retrospective observational studies, controlled trials, and systematic reviews reporting AKI in adult ED attendees within 24 hours of ED admission. Iatrogenic causes of AKI from medical interventions were excluded. We used PubMed to identify articles from 1996 to 14 August 2021, and adopted the National Heart, Lung, and Blood Institute (NHLBI) Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies to assess risk of bias. We used a forest plot to present the pooled ED-AKI incidence rates and I2 statistics. Other parameters were summarised narratively in a tabular form.
Results: We identified six articles using 24 hours from ED admission as the definition for ED-AKI from 2005 to 2018 in high-income settings and one article with a 48-hour timeframe. The pooled incidence of ED-AKI was 20 per 1000 adult ED attendances. Risk factors for ED-AKI included increasing age, nursing home residence, previous hospital admission within 30 days, discharge diagnosis of diabetes, obstructive uropathy, sepsis, gastrointestinal medical conditions, high serum creatinine, bilirubin, C-reactive protein, white blood cell, alanine aminotransferase, low serum sodium or albumin on admission, poor premorbid renal function, antibiotic use, active malignancy, lung disease, hyperlipidaemia, and infection. The crude, all-cause 24-hour mortality rate was 4.56% and one-year mortality was 35.04%. Increasing age and comorbidities including cardiovascular disease and malignancy were associated with higher mortality rates.
Conclusion: The review reveals high burden of ED-AKI. Compared to general AKI, ED-AKI has higher mortality rate and different risk factors. Main limitations include limited articles, heterogeneity of incidences, and no confounder adjustment. This calls for further research, red flag identification, and standardized management protocols for ED-AKI.
Predictive Models and Features of Patient Mortality across Dementia Types
Authors: Zhang Jimmy , Song Luo , Chan Kwun , Miller Zachary , Huang Kuan-lin 
Published: January 2023

Abstract
Dementia care is challenging due to the divergent trajectories in disease progression and outcomes. Predictive models are needed to identify patients at risk of near-term mortality. Here, we developed machine learning models predicting survival using a dataset of 45,275 unique participants and 163,782 visit records from the U.S. National Alzheimer’s Coordinating Center (NACC). Our models achieved an AUC-ROC of over 0.82 utilizing nine parsimonious features for all one-, three-, five-, and ten-year thresholds. The trained models mainly consisted of dementia-related predictors such as specific neuropsychological tests and were minimally affected by other age-related causes of death, e.g., stroke and cardiovascular conditions. Notably, stratified analyses revealed shared and distinct predictors of mortality across eight dementia types. Unsupervised clustering of mortality predictors grouped vascular dementia with depression and Lewy body dementia with frontotemporal lobar dementia. This study demonstrates the feasibility of flagging dementia patients at risk of mortality for personalized clinical management.