bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug‐Coated Balloon‐Based Treatment of Left Main True Bifurcation Lesion
Authors: Her Ae‐Young , Kim Tae Hyun , Shin Eun‐Seok , Kim Sunwon , Kim Bitna , Kim Yong Hoon , Choi Ki Hong , Cho Yun‐Kyeong , Lee Hyun‐Jong , Song Young Bin , Nam Chang‐Wook , Gwon Hyeon‐Cheol 
Published: January 2025

ABSTRACTBackgroundThere is a paucity of data regarding drug‐coated balloon (DCB) treatment in the context of left main (LM) true bifurcation lesions.AimsThe aim of this study was to evaluate the safety and efficacy of DCB‐based treatment for unprotected LM true bifurcation lesions.MethodsA total of 39 patients with LM true bifurcation lesion (Medina: 1,1,1/0,1,1/1,0,1) who were successfully treated with DCB alone or in combination with drug‐eluting stent (DES) were retrospectively enrolled into the DCB‐based group. They were compared with 39 propensity‐matched patients who were treated with second‐generation DES from the COBIS III registry (n = 2648). Major adverse cardiovascular events (MACE) were defined as cardiac death, myocardial infarction, stent or target lesion thrombosis, and target lesion revascularization at the 2‐year follow‐up.ResultsBaseline clinical characteristics were similar between the groups, except for the prevalence of in‐stent restenosis (ISR) lesions (41.0% in DCB‐based group vs. 17.9% in DES‐only group, p = 0.047). In the DCB‐based group, 59.0% of the patients (n = 23) underwent DCB‐only treatment. There were no cases of abrupt vessel closure requiring treatment following DCB application. The MACE were comparable between both groups (12.8% in DCB‐based group vs. 17.9% in DES‐only group, p = 0.861) after 2 years.ConclusionsIn patients with unprotected LM true bifurcation lesions, DCB‐based treatment demonstrated comparable clinical outcomes at the 2‐year follow‐up when compared to DES‐only treatment. DCB‐based treatment could be considered a safe and effective alternative to DES for carefully selected patients who have achieved satisfactory predilation results (Impact of DCB Treatment in De Novo Coronary Lesion; NCT04619277).
In Situ Electrochemically Deposited Mg Seeds Stabilizing the Lithium Metal Anode
Authors: Nan Wenzheng , Yan Shaojiu , Chen Xiang , Dai Sheng Long 
Published: January 2025

AbstractLithium metal, recognized for its extremely low reaction potential and ultrahigh theoretical specific capacity, is regarded as the “Holy Grail” of anode materials. However, the formation of lithium dendrites result in rapid cell capacity degradation and considerable safety issues, hindering its further advancement. In this study, in situ Mg seeds are generated on the lithium metal surface during cycling by incorporating MgCl2 into the electrolyte. These Mg seeds function as thiophilic sites, which lower the Li nucleation barrier and promote uniform Li nucleation and growth. Consequently, symmetric cells constructed with the carbonate electrolyte can cycle stably for over 400 h at a current density of 1 mA cm−2 and a capacity of 1 mAh cm−2. Notably, full cells using Li4Ti5O12 as the cathode can maintain stable cycling for 300 cycles, achieving a capacity retention rate of 71.9 %. This method has demonstrated its effectiveness in mitigating lithium dendrites formation and enhancing the performance of lithium metal batteries.
Fabrication of Carbon‐containing Nanoparticles in Chemistry Class
Authors: Bogdan Edwin , Waitz Thomas 
Published: January 2025

AbstractKohlenstoffhaltige Nanopartikel werden seit einigen Jahren intensiv als neuartige Funktionsmaterialien erforscht. Sie können aus kleineren Molekülen als Ausgangsstoffe, auch Präkursoren genannt, durch Pyrolyseprozesse hergestellt werden (Bottom Up). In folgendem Beitrag wird ein einfaches, direkt im Chemieunterricht einsetzbares Experiment zur Herstellung kohlenstoffhaltiger Nanopartikel vorgestellt, das als Präkursor den Naturstoff Saccharose nutzt. Es wird ein in der Fachliteratur formuliertes Reaktionsschema gezeigt und das Vorhandensein von Nanopartikeln durch Fluoreszenz bei Anregung mit UV‐Licht nachgewiesen. Das faszinierende Phänomen kann das Interesse von Schülerinnen und Schülern für die Thematik wecken und bietet curriculare Anschlussmöglichkeiten an die Chemie des Kohlenstoffs und die Nanochemie.
Phase 1 Mass Balance Study of Pizuglanstat: An Investigational Hematopoietic Prostaglandin D Synthase Inhibitor
Authors: Hanada Ryuzo , Takenaka Toru 
Published: January 2025

AbstractPizuglanstat is a novel hematopoietic prostaglandin D synthase inhibitor and investigational treatment for Duchenne muscular dystrophy. This Phase 1 mass balance study aimed to characterize the absorption, metabolism, and excretion of carbon‐14 (14C)‐labeled pizuglanstat in healthy adults (ClinicalTrials.gov, NCT04825431). After administering a single oral dose of [14C]pizuglanstat solution containing 400 mg of pizuglanstat and 1 megabecquerel of radioactivity to 6 healthy men (median age, 26 years), pizuglanstat in plasma reached a maximal concentration after a median of 0.5 hour and declined with a geometric mean half‐life of 7.7 hours. Pizuglanstat and its metabolites were primarily excreted via the fecal route; on average, 66.1% of administered radioactivity was excreted in feces after 168 hours, compared with 32.2% excreted in urine. Pizuglanstat was mostly present as the unchanged parent molecule in plasma, urine, and feces, while the sulfate conjugate of hydroxyl pizuglanstat was the major metabolite in each sample type. Two adverse drug reactions of urticaria were reported in 2 participants (33.3%); both events were nonsevere and manageable with treatment, and no other clinically significant safety events were observed. Overall, this study provides important pharmacokinetic, mass balance, and safety data to support the development of pizuglanstat as a new treatment for Duchenne muscular dystrophy.
Board Characteristics and Stakeholder Engagement and ESG Performance: The Relevance of European Gender Parity
Authors: Grau‐Grau Alfredo , Branco Manuel , Bel‐Oms Inmaculada 
Published: January 2025

ABSTRACTThe main goal of this study is to explore the effect of country‐level gender parity with a board characteristics and stakeholder engagement on ESG performance in sustainable companies. The sample comprises 940 sustainable international sustainable firm‐year observations from the following 13 countries: Denmark, Finland, France, Germany, Ireland, Italy, Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, and United Kingdom for the period 2013–2022. The results provide evidence that country‐level gender parity moderate negatively the effect of board gender diversity and busy directors on boards and ESG performance. Furthermore, the findings also show that country‐level gender parity moderate positively the effect of stakeholder engagement and ESG performance. When the ESG performance is separate in the three pillars, the results find that country‐level gender parity moderate negatively the effect of board gender diversity and busy directors on boards and governance performance while this effect is positively in the association between stakeholder engagement and governance performance. These results suggest that the governance pillar influence notably in the ESG performance. This study contributes to the scant research exploring the variation in the relationships between boards of directors' characteristics and ESG performance by focusing on one seldom explored of such sources, gender parity.
Exploring Ion Dynamics in Laser‐Produced Plasmas
Authors: Andrei Irimiciuc Stefan , Chertopalov Sergii , Novotny Michal , Craciun Valentin , Lancok Jan 
Published: January 2025

ABSTRACTCharged particle dynamics during transient plasma expansion have traditionally been studied within a consistent framework, supporting the advancement of applications like thin film deposition through pulsed laser ablation. However, reported plasma parameters often show inconsistencies, particularly in the relationship between ion mass and oscillation frequencies. Recent insights into charge current temporal traces have highlighted challenges in interpreting modulated probe currents. In this study, we present data on laser‐produced plasma (LPP) from Co targets and explore additional phenomena that more accurately describe the behavior of highly energetic, rapidly diffusing LPP.
Exploring the Prevalence of Renewable Energy Practices and Awareness Levels in Palestine
Authors: Abuhelwa Mai , Elnaggar Mohamed , Salah Wael A. , Nassar Yasser F. , Bashir Mohammed J. K. 
Published: January 2025

ABSTRACTThe growing demand for energy in developing societies, coupled with dwindling conventional resources, necessitates the adoption of renewable energy (RE) sources. A comprehensive understanding of these sources and their optimal utilization is crucial. The awareness of the users plays a very important role in the effective utilization of different energy sources. Hence, this study examines the level of RE awareness in Palestine, identifying factors influencing public perception and exploring potential strategies for promoting RE adoption. This awareness depends on different factors related to the users' education level, community type, and type of building. Different factors that affect the willingness and attitude to gain knowledge about RE are presented. In addition, various practices highlighting the increasing level of awareness regarding the adoption of RE sources are investigated. In addition, the status of RE education and its potential impact on engineers have also been discussed. Various individual and institutional efforts are highlighted in the study as strategies to bridge the gap and overcome obstacles to adopting RE sources. Suggestions for better use of these resources have been highlighted. Thereafter, recommendations for effective RE implementation in Palestine are analyzed and conclusions are drawn. The main challenges in integrating RE into Palestine's existing energy grid and system include infrastructure limitations, resources and financial constraints, and political issues. Still, there are possibilities in the form of international collaboration and investment. A flexible and modular RE grid could also address some of these challenges by integrating small‐scale systems that can be scaled up as needed.
Transoral Robotic Surgery in Chronic Lingual Tonsillitis: An Observational Cohort Study
Authors: Toppenberg Alexandra G. L. , Plaat Robert E. , Schwandt Leonora Q. 
Published: January 2025

ABSTRACTBackgroundChronic lingual tonsillitis (CLT) entails persistent inflammation of the lingual tonsils (LT), presenting in recurrent infections, throat discomfort, dyspnea, dysphagia, and LT hypertrophy.MethodsA retrospective observational study at a nonacademic general hospital described outcomes of CLT patients undergoing base of tongue (BOT) reduction via transoral robotic surgery (TORS). Primary outcomes were changes in patient‐reported quality of swallowing and life and were assessed at baseline, 3, 6, and 12 months post‐TORS. Secondary outcomes were tonsillitis complaints, LT Friedman grade, and postoperative complications.ResultsThirty‐three patients were included, 5 patients were lost to follow‐up at 6 and 12 months. Improved swallowing experience and enhanced quality of life were observed. Tonsillitis scores decreased significantly (mean 7.8 to 1.65 p < 0.001). LT Friedman grade reduced, with 69.7% achieving grade 0 at 12‐months follow‐up. Two patients experienced postoperative bleeding.ConclusionsTORS appears effective and safe for treating CLT improving swallowing, and overall quality of life for patients and reducing tonsillitis complaints.
Molecular cytogenetic study of the fetal genome in idiopathic recurrent pregnancy loss
Authors: Sadyrbekova Aigerim , Svyatova Gulnara , Berezina Galina , Suleimenova Roza , Murtazaliyeva Alexandra 
Published: January 2025

AbstractObjectiveDespite numerous studies on the causes of recurrent pregnancy loss (RPL), nearly half of cases remain unidentified, which determines the research relevance. This study aims to investigate microchromosomal variations in the fetal genome associated with the development of idiopathic RPL.MethodsThe research was supported by the Centre for Molecular Medicine and the Research Institute of Obstetrics, Gynecology and Perinatology and conducted over a period of 2 years. The study employed the Prepito automatic analyzer from PerkinElmer and the ChemagicPrepito nucleic acid extraction system, to isolate 100 DNA samples from conception products of women with idiopathic RPL, and, subsequently, to analyze for the presence of full‐genome chromosomal abnormalities by array comparative genomic hybridisation (aCGH) using CGX‐HD microarrays (8x60K), Format 1: CGX (80x60K), a ScanRI microarray scanner (PerkinElmer, Finland), and Genoglyphix, Cytogenomix software.ResultsThe study determined that 83% of the materials studied had a normal molecular karyotype, while unbalanced chromosomal abnormalities were detected in 17% of cases, of which 35.3% of abortions had aneuploidies and 64.7% had various structural abnormalities. Among the aneuploidies, 66.7% were trisomies and 33.3% were monosomies. In the group of structural disorders, 81.8% were microdeletions, while microduplications accounted for 18.2%. The data obtained on the frequency and structure of chromosomal abnormalities detected in abortions in the sample surveyed showed that idiopathic RPL is not caused by chromosomal abnormalities of embryos and, unlike all other forms of RPL, has a different cause not related to chromosomal abnormalities.ConclusionThis study conducted molecular cytogenetic analysis of the fetal genome related to RPL. Its findings can help optimize the process of counseling patients with idiopathic RPL.
The undertold story: A leadership program to expand recognition of the importance of early childhood experiences
Authors: Hinshaw Sarah , Finelli Julianna , Usry Lindsay , Knable Camille , Nagle Geoffrey , Zeanah Charles H. 
Published: January 2025

AbstractThere are considerable data documenting the importance of early experiences for healthy human development. Though widely accepted amongst mental health clinicians, developmental researchers and early childhood policymakers, this information is not well known by much of the public. We describe a specialized program designed for established and emerging leaders in Louisiana, United States of America, to help them become better informed to take action to support young children and their families and to facilitate connections across sectors for greater impact. Conducted annually for 6 years, the program drew leaders from a variety of professional sectors working in every region of the state. To evaluate the effectiveness of the program, we conducted semi‐structured interviews of program graduates and tabulated responses by thematic analysis. We conclude that translation efforts delivered in this kind of format can lead to gains in knowledge among leaders and action to support early childhood development and well‐being.
Adolescents Constructing Their Imagined Futures Through Dialogues With and/or About Nonfamilial Adults
Authors: Marshall Sheila K. , Young Richard A. , Charles Grant , Gotell Melanie , Ji Daniel , Wood Lydia 
Published: January 2025

ABSTRACTIntroductionAdolescents actively explore future imaginings as they prepare for major educational, work, and personal transitions. Although family members may support exploration of imagined futures, adults outside adolescents' kin network provide access to resources not supplied within the family. The purpose of this study was to understand how adolescents actively draw on social resources of nonfamilial adults relative to their imagined futures.MethodsAdolescents attending two schools in British Columbia, Canada participated in a year‐long study involving at least three face to face sessions and biweekly telephone calls. Participants (N = 13; eight identified as boys, four as girls, one as nonbinary; mean age = 14.92, SD = 1.60) were asked to invite nonfamilial adults from their social network to conversations about the future.ResultsTwo youth invited an adult to the research while the majority of participants (n = 11) explicitly changed the protocol by engaging with the researchers rather than bringing nonfamilial adults to the research. The change in the protocol was incorporated into analysis to try to understand participants' engagement in the research. Analysis revealed participants' overall intentions were to engage with adults, using the connections to test and refine imagined futures. Imagined future projects aligned with three clusters: practicing claims, navigating the line in the sand (difficulties crossing into adult realms), and resisting incongruent views of themselves.ConclusionFindings illustrate adolescents' intention to alter the study protocol rather than dropping out and how adolescents' engagement with nonfamilial adults supported opportunities to test and refine imagined futures in the service of constructing identities.
Standard Errors for Difference‐in‐Difference Regression
Authors: Hansen Bruce E. 
Published: January 2025

ABSTRACTThis paper makes a case for the use of jackknife methods for standard error, value, and confidence interval construction for difference‐in‐difference (DiD) regression. We review cluster‐robust, bootstrap, and jackknife standard error methods and show that standard methods can substantially underperform in conventional settings. In contrast, our proposed jackknife inference methods work well in broad contexts. We illustrate the relevance by replicating several influential DiD applications and showing how inferential results can change if jackknife standard error and inference methods are used.
A Clinical Drug as the Three‐Photon Fluorescence Probe for In Vivo Microscopic Imaging of Mouse Kidney
Authors: Geng Weihang , Xia Qiming , He Mubin , Wang Yi , Zheng Zheng , Qin Haiyan , Wang Yalun , Feng Jian , Qian Jun 
Published: January 2025

ABSTRACTThree‐photon fluorescence (3PF) microscopy encounters significant challenges in biological research and clinical applications, primarily due to the limited availability of high‐performance probes. We took a shortcut by exploring the excellent 3PF property of berberine hydrochloride (BH), a clinically utilized drug derived from the traditional Chinese medicine, Coptis. Capitalizing on its renal metabolism characteristics, we employed BH for in vivo 3PF microscopic imaging of the mouse kidney. This approach enabled high‐resolution structural observation of renal tubules and facilitated the diagnosis of drug‐induced acute kidney injury (AKI) based on renal tubule morphology. The analytical capabilities of 3PF microscopy for renal physiology and pathological diagnosis suggest its potential for future clinical applications.
MINFLUX Nanoscopy: A “Brilliant” Technique Promising Major Breakthrough
Authors: Salerno Marco , Bazzurro Virginia , Angeli Elena , Bianchini Paolo , Roushenas Mohammadmehdi , Pakravanan Kimiya , Diaspro Alberto 
Published: January 2025

ABSTRACTMINFLUX nanoscopy relies on the localization of single fluorophores with expected ~ 2 nm precision in 3D mapping, roughly one order of magnitude better than standard stimulated emission depletion microscopy or stochastic optical reconstruction microscopy. This “brilliant” technique takes advantage of specialized localization principles and algorithms that require only dim fluorescence signals with a minimum flux of photons; hence the name follows. With this level of performance, MINFLUX imaging and tracking should allow for the routine study of biological processes down to the molecular scale, revealing previously unresolved details in cell structures, such as the organization of calcium channels in muscle cells or the clustering of receptors in synapses. Whereas the high localization precision is definitely a strength of the MINFLUX technique, limitations and challenges also exist, especially in the labeling procedures aiming at appropriate density and on/off switching kinetics. This primer presents some significant results achieved with MINFLUX so far and highlights specific operational procedures crucial for this technique.
Diagnostic Performance of Different Examination Types and Learning Curves of Radiologists for 5G‐Based Robot‐Assisted Tele‐Ultrasonography
Authors: He Tian , Yang Kai‐Feng , Song Guo‐Chao , Liu Hui , Xu Guang , Wan Jing , Zhao Hui , Wang Qiao , Liu Chang , Chong‐Ke Zhao  , Zhang Yi‐Feng , Guo Le‐Hang , Sun Li‐Ping , Xu Hui‐Xiong 
Published: January 2025

ObjectiveTo investigate the feasibility of remotely providing routine ultrasound (US) examinations to patients using a fifth‐generation‐based robot‐assisted tele‐ultrasonography (RATU) system in a real‐world setting.MethodsBetween September 2020 and May 2021, we conducted a prospective and large‐scale study using the RATU system to provide US examinations for patients on a limited‐source island locate. An on‐site radiologist on the island performed US examinations, which served as the reference diagnosis. Five tele‐radiologists then remotely conducted RATU examinations from Central Shanghai. We compared the diagnostic performance of the RATU examinations to that of the on‐site US examinations. Additionally, we assessed the learning curves of the various tele‐radiologists. We also distributed 2 questionnaires to evaluate the usefulness of the clinical application.ResultsIn total, 770 patients were enrolled in the study with a mean age of 55.46 ± 15.02 years (ranging from 19 to 80 years). Out of the total, 501 patients were men, and 269 were women. Across all examination types, the diagnosis in 84.3% (649/770) of RATU examinations was consistent with the on‐site US examination. The learning curve was not significantly different between tele‐radiologists of different seniority. Furthermore, 86.6% (667/770) of participants accepted the RATU examination, and 97.5% (751/770) of patients were willing to pay a fair price.ConclusionRATU's diagnostic performance is still helpful for patients in remote areas, even though it may be slightly inferior to on‐site US examination.
CP/HA/HGF Conductive Composite Scaffolds with Synergistic Electrical Stimulation for Nerve Regeneration
Authors: Ma Yahao , Wang Cong , Li Jun , Xie Pengfei , Xiao Longyou , Ramakrishna Seeram , Chen Nuan , Wang Xiaoying , He Liumin 
Published: January 2025

AbstractThe challenge of nerve regeneration stems from the diminished vitality of mature neurons post‐injury. The construction of a suitable microenvironment at the injury site to facilitate axonal regeneration is a crucial aspect of nerve injury repair. In this work, a conductive and biocompatible composite material, CP/HA/HGF, is designed by grafting polypyrrole onto chitosan and compounding it with hyaluronic acid and functional short peptides for neural regeneration. Comprehensive material characterizations shows that CP/HA/HGF holds the potential as a scaffold material based on its good overall performance. In vitro experiments revealed that the combination of conductive composite scaffolds and electrical stimulation facilitated axonal growth and myelin formation in the dorsal root ganglion, while also promoting the migration of Schwann cells. Therefore, the conductive composite scaffold studied in this paper presents a promising strategy for enhancing neural regeneration.