bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐object optimization study on the performance of gas cyclones based on heterogeneous condensation and turbulent agglomeration
Authors: Wang Jiarui , Peng Xiaocheng , Song Chen , Wen Jian , Wang Simin 
Published: April 2023

AbstractImproving the separation efficiency of fine particles becomes more and more critical as environmental pollution aggravates. This study aims to investigate the effects of four key parameters on the performance of gas cyclones, including cyclone body height, particle concentration, initial supersaturation degree, and inlet temperature. Then, the two‐way coupling numerical model, in which is the process of heterogeneous condensation and agglomeration for insoluble fine particles, was achieved by user defined function. On this basis, the response surface analysis method and multi‐objective genetic algorithm were adopted to optimize the cyclone. The results show that when the particle concentration is less than 1000 mg/m3, the separation efficiency can reach above 95%. The initial supersaturation degree has the greatest effect on the separation efficiency and vapour consumption rate, while the cyclone body height is the most critical factor on the pressure drop. As the particle concentration increases, the separation efficiency decreases at first and then keeps almost stable. With the increase of inlet temperature, the separation efficiency is enhanced, and the pressure drop reduces. These research results can provide important guidance for the optimization and engineering application of this technology.
Psychosocial outcomes in long‐term Dutch adult survivors of childhood cancer: The DCCSS‐LATER 2 psycho‐oncology study
Authors: Maas Anne , Maurice‐Stam Heleen , Kremer Leontien C. M. , van der Aa‐van Delden Alied , van Dulmen‐den Broeder Eline , Tissing Wim J. E. , Loonen Jacqueline J. , van der Pal Helena J. H. , de Vries Andrica C. H. , van den Heuvel‐Eibrink Marry M. , Ronckers Cécile , Neggers Sebastian , Bresters Dorine , Louwerens Marloes , van der Heiden‐van der Loo Margriet , van Gorp Marloes , Grootenhuis Martha ,   Dutch LATER study group
Published: April 2023

AbstractBackgroundThis study compares a comprehensive range of psychosocial outcomes of adult childhood cancer survivors (CCS) to general population‐based references and identifies sociodemographic and medical risk factors.MethodsCCS from the Dutch Childhood Cancer Survivor Study (DCCSS)‐LATER cohort (diagnosed 1963–2001) part 2 (attained age ≥18 years, diagnosed <18 years, ≥5 years since diagnosis) completed the Rosenberg Self‐Esteem Scale, Hospital Anxiety and Depression Scale, Distress Thermometer, Self‐Rating Scale for Post‐Traumatic Stress Disorder, and the Short Form‐36 (Health Related Quality of Life). CCS’ scores were compared with references using analysis of variances and logistic regression analysis, controlling for age and sex (p < .05). Risk factors for worse psychosocial outcomes were assessed with regression analyses (p < .05).ResultsCCS, N = 1797, mean age 35.4 years, 49.0% female, all ≥15 years since diagnosis, participated. Three percent reported posttraumatic stress disorder because of childhood cancer and 36.6% experienced clinical distress. CCS did not differ from references on self‐esteem and anxiety but were less depressed (d = −.25), and scored poorer on all health‐related quality of life scales, except for bodily pain (.01 ≤ d ≥ −.36). Female sex, lower educational attainment, not being in a relationship, and being unemployed were negatively associated with almost all psychosocial outcomes. Except for a central nervous system tumor diagnosis, few medical characteristics were associated with psychosocial outcomes.ConclusionCCS appear resilient regarding mental health but have slightly poorer health‐related quality of life than references. Sociodemographic characteristics and central nervous system tumors were related to most psychosocial outcomes, but no clear pattern was observed for other medical factors. Future studies should address additional factors in explaining CCS’ psychosocial functioning, such as coping, social support, and physical late effects.
Dual‐networks Enhanced Hollow ZIF‐8 Particles for Water Treatment
Authors: Xia Lingling , Li Yucen , Cui Jiwei , Hu Ming 
Published: April 2023

AbstractHollow ZIF‐8 particles are promising materials for water treatment because of the high porosity and catalytic activities under photon irradiation. However, hollow ZIF‐8 particles can easily degrade under harsh conditions due to the weak stability. Here, we synthesize hollow ZIF‐8 particles with polyphenol and polyethylene glycol networks embedded. The multiple interactions among the ZIF‐8 frameworks and the networks increase the mechanical and chemical stability of the hollow ZIF‐8 particles as suggested by a series of spectra. Uptake of methylene blue about 128 mg/g by the hollow particles is realized. Furthermore, hydroxyl or superoxide radicals for degradation of the adsorbed methylene blue are effectively generated through irradiation of the hollow ZIF‐8 particles. In a water treatment test, the model pollute with a concentration of 50 mg/L is completely removed within half an hour. The performance of the recycled hollow ZIF‐8 particles is proved to be significant, indicating the practical potential of the material.
The relationship among psychological distress, well‐being and excessive social media use during the outbreak of Covid‐19: A longitudinal investigation
Authors: Brailovskaia Julia , Margraf Juergen , Ceccatelli Sara , Cosci Fiammetta 
Published: April 2023

AbstractIntroductionThe corona pandemic has been a life event causing negative consequences on mental health. Mental health consists of positive and negative dimensions. The present longitudinal study investigated how positive and negative dimensions changed over 15 months after the Covid‐19 outbreak. Potential changes of excessive social media use (SMU) and its relationship with mental health were also investigated.MethodData (N = 189) on distress (measured overall and as depression, anxiety, and stress), well‐being and excessive SMU were collected at three time points (baseline, BL; 3‐month follow‐up, FU1; 15‐month follow‐up, FU2) via online surveys in Italy. Repeated analyses of variance were used to test differences among the three measurement time points. Mediational models were applied.ResultsDistress did not change over time, well‐being decreased and excessive SMU increased significantly. The relationship between distress at BL and excessive SMU at FU2 was significant (total effect, c: p < .001). The relationship between distress at BL and well‐being at FU1 (a: p < .001), and between well‐being at FU1and excessive SMU at FU2 (b: p = .004) was significant. Including FU1 well‐being in the model, the relationship between distress at BL and excessive SMU at FU2 was not significant (direct effect, c′: p = .078). The indirect effect (ab) was significant.ConclusionWell‐being mediated the relationship between baseline stress and excessive SMU. Enhanced stress may reduce well‐being which, in turn, increases the risk of excessive SMU. This emphasizes the urgency of programmes that foster well‐being, especially during stressful events such as a pandemic.
A new single ended primary inductor converter with high voltage gain, low voltage stress and continuous input current
Authors: Jahangiri Alireza , Abdolalizadeh Ali , Shamim Ahmad Ghaderi 
Published: April 2023

SummaryThis paper proposes a single‐ended primary‐inductor converter (SEPIC)‐based DC‐DC converter with higher voltage gain, continuous input current, and lower voltage stress. Suggested converter uses three‐winding coupled inductors and voltage multiplier for boosting function. The proposed structure stores lower amount of energy due to lower current magnitudes of used inductors. Moreover, using voltage multiplier reduces the voltage stress of the elements connected to the output terminals of the proposed converter. By reducing the voltage stress, in addition to reducing the rating of output elements and costs, the overall efficiency will also be increased. Also, a clamping circuit is used to diminish the voltage stresses on power switch. In order to represent the advantages of the proposed converter over some other converters in the viewpoints of the number of the used elements, continuity of input current, voltage gain, the voltage stress on power switch, and output diode, a comparison study is provided. To validate the practicability of the proposed converter, a 200‐W prototype is implemented and the experimental results are provided.
A multiplex qPCR assay for transgenes detection: A novel approach for gene doping control in horseracing using conventional laboratory setup
Authors: Wong Kin‐Sing , Cheung Hiu Wing , Szeto Cherry W. L. , Tsang Candice Y. N. , Wan Terence S. M. , Ho Emmie N. M. 
Published: April 2023

AbstractIllicit administration of transgene into horses is a form of gene doping that has been a key concern in equine sports. The large number of potential performance‐enhancing transgenes has demanded a cost‐effective and reliable detection method. Multiplex qPCR is a relevant technique, but the cross‐talking between fluorophores and high background noise limits the method sensitivity and specificity. This study reports a simpler multiplexing approach by using the same fluorophore for four hydrolysis probes each targeting one of the four transgenes: human growth hormone, insulin‐like growth factor 1, equine erythropoietin and interleukin‐10. Any positive findings from this multiplex qPCR assay can then be confirmed by individual qPCR assays to identify potential transgene(s). This has effectively eliminated the cross‐talking issue and allowed an improved signal‐to‐noise than conventional multiplex qPCR assay. It has also removed the limitation imposed by the available choice of fluorophores and optical channels of qPCR instruments on the number of transgenes that can be analysed in a multiplex qPCR assay. This novel multiplex qPCR has been successfully validated. The estimated limits of detection were ~1500–2500 copies/mL of blood, thus demonstrating comparable sensitivity with the corresponding duplex qPCR assays. Concurring results were obtained by analysing hundreds of official blood samples provided by racehorses with this multiplex qPCR assay and the accredited individual duplex qPCR assays. This novel multiplex qPCR assay for detecting multiple transgenes is a cost‐effective screening method using a conventional laboratory setup and has opened up the potential to include the testing of additional transgenes in a single assay.
Phosphodiesterase‐5 inhibitors for left ventricular assist device implantation complicated by right ventricular failure
Authors: Papathanasiou Maria , Jakstaite Aiste‐Monika , Mincu Raluca , Wernhart Simon , Ruhparwar Arjang , Rassaf Tienush , Luedike Peter 
Published: April 2023

AbstractAimsPhosphodiesterase‐5 inhibitors (PDE5I) are frequently implemented after left ventricular assist device (LVAD) implantation to improve haemodynamics in patients with early postoperative right ventricular (RV) failure. It is unknown if long‐term PED5I therapy beyond the early post‐operative period provides any clinical benefit in stable outpatients, who have recovered from post‐operative RV failure under univentricular device support. This study aimed to investigate the impact of PDE5I discontinuation on RV function and cardiopulmonary exercise capacity in patients on durable LVAD support.Methods and resultsWe enrolled 31 clinically stable LVAD recipients on long‐term oral PDE5I therapy. The mean age was 53 years, and 90% were male. Patients discontinued PDE5I and underwent cardiopulmonary exercise testing, echocardiography, LVAD interrogation, and biomarker analysis at baseline and 4 weeks after PDE5I withdrawal. At 4 weeks, no significant changes were observed in echocardiographic indices of RV morphology and function but an increase in peak tricuspid regurgitation velocity (2.1 vs. 2.4 m/s, P = 0.01). Peak oxygen consumption (11.4 vs. 11.8 mL/min/kg, P = 0.52), minute ventilation/carbon dioxide production slope (33 vs. 35, P = 0.56), N‐terminal pro‐brain natriuretic peptide (1455 vs. 1399 pg/mL, P = 0.55), flow and power readings of the device, and quality of life (Kansas City Cardiomyopathy Questionnaire score 78.3% vs. 77.5%, P = 0.62) exhibited no significant changes. We observed an increase in 6‐min walking distance (346 vs. 364 m, P = 0.03). Two patients were hospitalized for non‐cardiac reasons (subtherapeutic INR, driveline infection). No patient was hospitalized for cardiac decompensation.ConclusionsIn LVAD patients with a history of early post‐operative RV failure, discontinuation of long‐term PDE5I therapy was not associated with deterioration of RV function, exercise capacity, and quality of life. PDE5I should be critically evaluated until more evidence regarding the net clinical benefit of this pharmacologic intervention becomes available.
TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages
Authors: Curson James E.B. , Liu Liping , Luo Lin , Muusse Timothy W. , Lucas Richard M. , Gunther Kimberley S. , Vajjhala Parimala R. , Abrol Rishika , Jones Alun , Kapetanovic Ronan , Stacey Katryn J. , Stow Jennifer L. , Sweet Matthew J. 
Published: April 2023

AbstractTLRs engage numerous adaptor proteins and signaling molecules, enabling a complex series of post‐translational modifications (PTMs) to mount inflammatory responses. TLRs themselves are post‐translationally modified following ligand‐induced activation, with this being required to relay the full spectrum of proinflammatory signaling responses. Here, we reveal indispensable roles for TLR4 Y672 and Y749 phosphorylation in mounting optimal LPS‐inducible inflammatory responses in primary mouse macrophages. LPS promotes phosphorylation at both tyrosine residues, with Y749 phosphorylation being required for maintenance of total TLR4 protein levels and Y672 phosphorylation exerting its pro‐inflammatory effects more selectively by initiating ERK1/2 and c‐FOS phosphorylation. Our data also support a role for the TLR4‐interacting membrane proteins SCIMP and the SYK kinase axis in mediating TLR4 Y672 phosphorylation to permit downstream inflammatory responses in murine macrophages. The corresponding residue in human TLR4 (Y674) is also required for optimal LPS signaling responses. Our study, thus, reveals how a single PTM on one of the most widely studied innate immune receptors orchestrates downstream inflammatory responses.
Synthesis of Cytotoxic Iron‐Containing Macrocycles Through Unexpected C(sp2)−C(sp2) Bonds Formation
Authors: Torres‐Gutiérrez Carolina , Estrada‐Montaño Aldo S. , Orvain Christophe , Mellitzer Georg , Gaiddon Christian , Le Lagadec Ronan 
Published: April 2023

AbstractIn previous reports, it has been demonstrated that cyclometalated iron(II/III) complexes can be prepared by reacting iron(0) precursors and mercurated or brominated derivatives. However, in this report, the reaction between [Fe3(CO)12] and mercurated 6‐phenyl‐2,2′‐bipyridine or brominated 2,6‐diphenyl‐pyridine pincer derivatives led to compounds in which C(sp2)−C(sp2) bonds have been formed between two ligands. A 16‐electron iron(II) complex (1Cl) bearing a tetradentate ligand originating from the dimerization of 6‐phenyl‐2,2′‐bipyridine was isolated, while a protonated 14‐membered macrocycle with [FeBr4]− as counterion (2) was obtained from 2,6‐diphenyl‐pyridine. Studies by X‐ray diffraction crystallography, NMR, UV‐vis and cyclic voltammetry confirmed the structures. Additionally, the cytotoxicity of the new compounds toward gastric cancer cell lines was evaluated, and it was established that the presence of the iron(II) center was crucial for an elevated activity.
Amperometric detection of indapamide on glassy carbon electrode
Authors: Oliveira Thawan G. , Santos Berlane G. , Gonçalves Josué M. , Angnes Lucio 
Published: April 2023

AbstractThis work describes the development of a fast, precise and reliable voltammetric method for the quantification of indapamide, an orally active diuretic sulfonamide used for hypertensive treatment. This compound acts inhibiting sodium reabsorption and increasing the elimination of water. This characteristic was responsible for its banishment by the International Olympic Committee since 1999. The study begins by finding an adequate potential range (−0.20 to 0.30 V) to avoid poisoning the working glassy carbon electrode (GCE) in phosphate buffer 0.10 mol L−1(pH=12.0). Utilizing flow injection analysis, linear responses between 2.0 × 10−6 mol L−1to 2.5 × 10−5 mol L−1of indapamide (R2=0.995), and detection limit (LOD) 3.0 × 10−7 mol L−1were obtained. This method was applied for the quantification of indapamide in tablets and in synthetic urine. The same flow system was used for the analysis of commercial drugs and the response obtained corresponded to 98 % of the concentration indicated on the drug label. These tablets were also analyzed by high performance liquid chromatography (HPLC), obtaining a recovery of 103 % and LOD 4.0 × 10−7 mol L−1. The velocity of analysis using flow methods compares advantageously to the classical chromatographic methods. For synthetic urine, linear responses were obtained in samples spiked in the region from 5.0 × 10−6 mol L−1to 30 × 10−6 mol L−1(R2=0.991) and LOD 3.0 × 10−7 mol L−1.
Effect of detonation nanodiamonds on the electrocatalytic activity of asymmetric cobalt phthalocyanine: Covalent versus non‐covalent linking
Authors: Ncwane Lunathi , Mpeta Lekhetho S. , Nyokong Tebello 
Published: April 2023

AbstractWe report on the effect of detonation nanodiamonds (DNDs) on electrocatalytic properties of an asymmetrically substituted cobalt phthalocyanine (CoPc). The incorporation of DNDs onto cobalt phthalocyanine enhances its electrochemical behaviour. An asymmetrical CoPc alone, when π‐π stacked (CoPc‐DNDs(ππ)) or covalently linked (CoPc@DNDs) to DNDs is used to modify a glassy carbon electrode (GCE) for the electrocatalytic detection of hydrazine. In addition, the GCE was modified by sequentially adding CoPc and DNDs onto its surface, represented as GCE/CoPc‐DNDs(seq) when CoPc is placed before DNDs on the electrode and GCE/DNDs‐CoPc(seq) when DNDs are placed before CoPc, where seq represents sequential. The obtained catalytic rate for the detection of hydrazine on GCE/CoPc@DNDs was 9.3×104 M−1.s−1 with a limit of detection as 0.33 μM. GCE/CoPc@DNDs gave better electrocatalytic activities when compared to its counterparts.
Synthesis of semiconductor ZnO nanostructures using Arctostaphylos pungens extract applicated in the photodegradation of water pollutions
Authors: Quevedo‐Robles Reina Vianey , Vilchis‐Nestor Alfredo Rafael , Luque Priscy 
Published: April 2023

AbstractThe presence of dyes in water can have severe health and environmental implications; consequently, effective technologies are required to remove them. In this research, ZnO nanoparticles (NPs) have been synthesized by eco‐friendly methods, using Arctostaphylos pungens extract, for use in water treatment via photocatalysis. The extract concentration strongly influenced the properties of ZnO NPs, the bandgap values revealed a direct dependence as the extract concentration increased, obtaining 2.81, 2.88, and 2.92 eV for 1%, 2%, and 4% w/v (weight/volume), respectively. In contrast, the NPs presented quasi‐spherical morphologies with a decrease in size from 24, 20, and 17 nm in response to extract concentration variations. The ZnO formation was confirmed by Fourier transform infrared, energy‐dispersive x‐ray, and x‐ray diffraction. ZnO NPs showed high photocatalytic activity with the dyes methylene blue (MB) and methyl orange (MO) under UV light, achieving 96% photodegradation of MB in just 60 min. Meanwhile, MO showed 93% of degradation at 180 min. Additionally, under solar radiation, significant photocatalytic activity was also observed, obtaining 92% and 81% photodegradation for MB and MO, respectively. The results indicate that ZnO NPs green synthesized using A. pungens extract can be used in water treatment as a friendly and efficient catalyst for the photodegradation of dyes.
Effective multi‐step ahead container throughput forecasting under the complex context
Authors: Xiao Yi , Xie Minghu , Hu Yi , Yi Ming 
Published: April 2023

AbstractAccurate and effective container throughput forecasting plays an essential role in economic dispatch and port operations, especially in the complex and uncertain context of the global Covid‐19 pandemic. In light of this, this research proposes an effective multi‐step ahead forecasting model called EWT‐TCN‐KMSE. Specifically, we initially use the empirical wavelet transform (EWT) to decompose the original container throughput series into multiple components with varying frequencies. Subsequently, the state‐of‐the‐art temporal convolutional network is utilized to predict the decomposed components individually, during which an improved loss function that combines mean square error (MSE) and kernel trick is employed. Eventually, the deduced prediction results can be obtained by integrating the predicted values of each component. In particular, this research introduces the MIMO (multi‐input and multi‐output) strategy to conduct multi‐step ahead container throughput forecasting. Based on the experiments in Shanghai port and Ningbo‐Zhoushan port, it can be found that the proposed model shows its superiority over benchmark models in terms of accuracy, stability, and significance in container throughput forecasting. Therefore, our proposed model can assist port operators in their daily management and decision making.
TAF15::NR4A3 gene fusion identifies a morphologically distinct subset of extraskeletal myxoid chondrosarcoma mimicking myoepithelial tumors
Authors: Warmke Laura M. , Wang Wei‐Lien , Baumhoer Daniel , Andrei Vanghelita , Ameline Baptiste , Baker Michael L. , Kerr Darcy A. 
Published: April 2023

AbstractExtraskeletal myxoid chondrosarcoma (EMC) is a rare sarcoma of uncertain differentiation predominantly arising in deep soft tissue. Its conventional morphologic appearance manifests as a relatively well‐circumscribed, multilobular tumor composed of uniform short spindle‐to‐ovoid primitive mesenchymal cells with deeply eosinophilic cytoplasm arranged in anastomosing cords within abundant myxoid matrix. The genetic hallmark of EMC has long been considered to be pathognomonic gene rearrangements involving NR4A3, which when fused to TAF15, often have high‐grade morphology with increased cellularity, moderate to severe cytologic atypia, and rhabdoid cytomorphology. Herein, we describe two cases of EMC with TAF15::NR4A3 fusion that appear morphologically distinct from both conventional and high‐grade EMC. Both cases had an unusual biphasic appearance and showed diffuse positivity for p63, mimicking myoepithelial tumors. DNA methylation profiling demonstrated that both cases clearly cluster with EMC, indicating that they most likely represent morphologically distinct variants of EMC. The clinical significance and prognostic impact of this morphologic variance remains to be determined. Molecular testing, including DNA methylation profiling, can help to confirm the diagnosis and avoid confusion with mimics; it adds another layer of data to support expanding the morphologic spectrum of EMC.