bluuebunny/crossref_metadata_2025_split huggingface dataset:
The First Discovery of Authigenic Carbonates on the Laptev Sea Flank of Gakkel Ridge (Arctic Ocean)
Authors: Kaminskii D. V. , Chamov N. P. , Krylov A. A. , Neevin I. A. , Buyakaite M. I. , Degtyarev K. E. , Dubenskii A. S. , Kaminskii V. D. , Logvina E. A. , Okina O. I. , Semenov P. B. , Kil A. O. , Petrov O. V. , Pokrovskii B. G. , Tolmacheva T. Yu. 
Published: August 2023

Abstract
This paper describes the first finding of authigenic carbonates on the southern flank of Gakkel Ridge in its junction with the continental margin of the Laptev Sea of the Russian Federation. The samples are represented by compact magnesian calcites and aragonites, including rounded and angular fragments of terrigenous material, as well as microphytoplankton and spores and pollen of terrestrial and aquatic plants of various ages. The elemental and organochemical characteristics are indicative of the predominant oxidation conditions or those intermediate between oxidation and reduction conditions of carbonate crystallization likely due to the fact that carbonates were formed near the bottom surface. The O, C, and Sr isotopic compositions make it possible to conclude that diagenetic carbonates of Gakkel Ridge were deposited mainly in isotopic equilibrium with bottom water at a temperature of about 0°C, corresponding to measurements from the research vessel. A wide range of δ13С (from –23.5 to –37.3) is indicative of the fact that methane was an important, but not the sole source of carbon in carbonates. Based on wide variations in 87Sr/86Sr (0.70906–0.70933) correlated with δ13С values, the carbonate-forming fluid was not only modern seawater, but also diagenetic solutions coming from the sedimentary cover together with methane and methane and organic matter oxidation products. The active discharge of heterogeneous methane-bearing fluids can be related to the high modern tectonic activity of the study region.
Effect modifications of BMI transition and trajectory in the associations of adverse childhood experiences with new-onset dementia and its subtypes in older US adults
Authors: Ren Ziyang , Su Binbin , Du Yushan , Zhou Tianjing , Zheng Xiaoying , Liu Jufen 
Published: August 2023

BackgroundAdverse childhood experiences (ACEs) and dementia are associated and comorbid with obesity. However, according to emerging research, the role of obesity in the association between ACEs and dementia seems controversial.AimsThis analysis aimed to explore the associations between ACEs and different dementia subtypes and the effect modification of long-term body mass index (BMI).MethodsData were obtained from the US Health and Retirement Study. Six ACEs were categorised as 0, 1 and 2 or more. All-cause dementia, Alzheimer’s disease (AD) and other dementias were defined by self-reported or proxy-reported physician diagnosis. Cox proportional hazards regression was used to explore the associations of ACEs with new-onset all-cause dementia, AD and other dementias from 2010 to 2020. Effect modification of BMI in 2010 and BMI transition and trajectory (fitted by group-based trajectory modelling) from 2004 to 2010 were assessed.Results15 282 participants with a mean age of 67.0 years (58.0–75.0) were included in the 2010 data analysis. Significant interactions of ACEs with baseline BMI, BMI transition and BMI trajectory in their associations with new-onset all-cause dementia and AD were observed (all p<0.05). For instance, positive associations of two or more ACEs (vs none) with all-cause dementia and AD were found in those with a BMI trajectory of maintaining ≥30 kg/m2(maintain obesity) rather than a decline to or maintaining <25 kg/m2(decline to or maintain normal weight), with hazard ratios (HRs) of 1.87 (95% confidence interval (CI): 1.45 to 2.42) and 1.85 (95% CI: 1.22 to 2.80), respectively.ConclusionsACEs were associated with dementia and AD in US adults with long-term abnormally elevated BMI but not with long-term normal or decreasing BMI. Integrated weight management throughout life could prevent dementia among those with childhood adversity.
Clinicians and AI use: where is the professional guidance?
Authors: Smith Helen , Downer John , Ives Jonathan 
Published: August 2023

With the introduction of artificial intelligence (AI) to healthcare, there is also a need for professional guidance to support its use. New (2022) reports from National Health Service AI Lab & Health Education England focus on healthcare workers’ understanding and confidence in AI clinical decision support systems (AI-CDDSs), and are concerned with developing trust in, and the trustworthiness of these systems. While they offer guidance to aid developers and purchasers of such systems, they offer little specific guidance for the clinical users who will be required to use them in patient care.This paper argues that clinical, professional and reputational safety will be risked if this deficit of professional guidance for clinical users of AI-CDDSs is not redressed. We argue it is not enough to develop training for clinical users without first establishing professional guidance regarding the rights and expectations of clinical users.We conclude with a call to action for clinical regulators: to unite to draft guidance for users of AI-CDDS that helps manage clinical, professional and reputational risks. We further suggest that this exercise offers an opportunity to address fundamental issues in the use of AI-CDDSs; regarding, for example, the fair burden of responsibility for outcomes.
A semi-analytical solution for laterally loaded non-circular piles in elastic soil
Authors: Zhou Hang , Wang Zengliang , Basu Dipanjan , Liu Hanlong 
Published: August 2023

The traditional method for analysis and design of laterally loaded piles with non-circular cross-sections such as rectangular, H-shaped, and X-shaped piles involves the simplification of converting the non-circular pile to a circular pile with equivalent second moment of inertia. A rigorous semi-analytical method is developed for calculating the response for laterally loaded piles with arbitrary non-circular cross-sections in multi-layered elastic soil without using any simplification regarding the shape of the pile cross-section. The governing differential equations for the pile–soil system are obtained using the principle of virtual work. The soil displacements around the pile are described as products of separable functions that are compatible with horizontal pile movement. As a result, the three-dimensional (3 D) boundary value problem (BVP) is described by a fourth-order linear ordinary differential equation (ODE) governing horizontal pile displacement and second-order partial differential equations (PDEs) governing soil displacements. New solution techniques for the ODE and PDEs are proposed, and the accuracy of the present method is verified by comparing the predicted pile and soil responses with the corresponding results of equivalent 3 D finite element method. The effects of pile cross-section shape and lateral loading direction on the pile and soil responses are highlighted through a series of parametric analyses.
Free Speech and its Limits in the UK Parliament
Authors: Manu Thaddeus 
Published: August 2023

Abstract
The notion of Parliamentary supremacy in the United Kingdom’s constitution remains unquestionable. However, the legislative intent of Article 9 of the Bill of Rights 1689 which provides that debates or proceedings in Parliament ought not to be impeached or questioned in any Court or place out of Parliament appears to undermine rules and principles that have been established in a system of jurisprudence for the promotion of administration of justice and enforcement of other rights. The question is whether there should be limitations on Parliamentary privilege on free speech to preclude wilful disregard of Court injunctions. This article argues that the invocation of Parliamentary privilege on free speech in wilful disregard of Court’s injunction undermines the universal principles applicable to the rule of law, breaches the sub judice rule, threatens the constitutional role of the Courts in the administration of justice and damages the comity that exist between Parliament and the Courts.
Kinetic Energy Exchanges between a Two-Dimensional Front and Internal Waves
Authors: Kar Subhajit , Barkan Roy 
Published: August 2023

Abstract
Fronts and near-inertial waves (NIWs) are energetic motions in the upper ocean that have been shown to interact and provide a route for kinetic energy (KE) dissipation of balanced oceanic flows. In this paper, we study these KE exchanges using an idealized model consisting of a two-dimensional geostrophically balanced front undergoing strain-induced semigeostrophic frontogenesis and internal wave (IW) vertical modes. The front–IW KE exchanges are quantified separately during two frontogenetic stages: an exponential sharpening stage that is characterized by a low Rossby number and is driven by the imposed strain (i.e., mesoscale frontogenesis), followed by a superexponential sharpening stage that is characterized by an Rossby number and is driven by the convergence of the secondary circulation (i.e., submesoscale frontogenesis). It is demonstrated that high-frequency IWs quickly escape the frontal zone and are very efficient at extracting KE from the imposed geostrophic strain field through the deformation shear production (DSP). Part of the extracted KE is then converted to wave potential energy. On the contrary, NIWs remain locked to the frontal zone and readily exchange energy with the ageostrophic frontal circulation. During the exponential stage, NIWs extract KE from the geostrophic strain through DSP and transfer it to the frontal secondary circulation via the ageostrophic shear production (AGSP) mechanism. During the superexponential stage, a newly identified mechanism, convergence production (CP), plays an important role in the NIW KE budget. The CP transfers KE from the convergent ageostrophic secondary circulation to the NIWs and largely cancels out the KE loss due to the AGSP. This CP may explain previous findings of KE transfer enhancement from balanced motions to IWs in frontal regions of realistic ocean models. We provide analytical estimates for the aforementioned energy exchange mechanisms that match well the numerical results. This highlights that the strength of the exchanges strongly depends on the frontal Rossby and Richardson numbers.

Significance Statement
Fronts with large horizontal density and velocity gradients are ubiquitous in the upper ocean. They are generated by a process known as frontogenesis, which is often initialized by straining motions of mesoscale balanced circulations. Here we examine the energy exchanges between fronts and internal waves in an idealized configuration, aiming to elucidate the mechanisms that can drain energy from oceanic balanced circulations. We identify a new mechanism for energy transfers from the frontal circulation to near-inertial internal waves called convergence production. This mechanism is especially effective during the later stages of frontogenesis when the convergent ageostrophic secondary circulation that develops is strong.
Anogenital distance, a biomarker of fetal androgen exposure and the risk of prostate cancer: A case-control study
Authors: Marín-Martínez Florencio Manuel , Arense-Gonzalo Julian J , Artes Miriam Artes , Bobadilla Romero Emny Rochell , García Porcel Víctor Javier , Alcon Cerro Pablo , Suárez-Pineda Mabel Coromoto , Guzmán Martínez- Valls Pablo Luis , Mendiola Jaime 
Published: August 2023

Anogenital distance (AGD) is a biomarker and a sexual dimorphism measure that can be modulated by hormonal factors, like anti-androgens, responding to gestational exposure along fetal period. There seems to be a prenatal window period in which specific environmental exposures can result in increased risk of suffer hormone-dependent neoplasms, like prostate cancer (PCa). Objective: Evaluate the association between AGD and the risk of PCa. Methods: Incident case-control study, conducted on 153 patients. All patients underwent prostate biopsy for abnormal digital rectal exam and/or prostate antigen elevation. Two variants of AGD [anus to scrotum base (AGDas) and anus to dorsal insertion of penis (AGDap) were measured. Student’s t-test was used to analyze continuous variables and chi-square for discrete variables. Differences in AGD (raw and adjusted) measures between cases and controls were assessed using the ANCOVA test. Results: There is significant association between the diagnose of PCa and both AGD, patients diagnosed with PCa had both AGD measures shortened, in the crude and the full adjusted models. Conclusions: This research suggests that the same gestational environmental exposures, could represent a weak androgen signaling and may also have an increased risk of prostate cancer.
Aspartyl tRNA-synthetase (AspRS) gene family enhances drought tolerance in poplar through BABA-PtrIBIs-PtrVOZ signaling module
Authors: Feng Cong-Hua , Niu Meng-Xue , Zhao Shilei , Guo Shangjing , Yin Weilun , Xia Xinli , Su Yanyan 
Published: August 2023

Abstract
Background
Drought stress is a prevalent abiotic stress that significantly hinders the growth and development of plants. According to studies, β-aminobutyric acid (BABA) can influence the ABA pathway through the AtIBI1 receptor gene to enhance cold resistance in Arabidopsis. However, the Aspartate tRNA-synthetase (AspRS) gene family, which acts as the receptor for BABA, has not yet been investigated in poplar. Particularly, it is uncertain how the AspRS gene family (PtrIBIs)r can resist drought stress after administering various concentrations of BABA to poplar.

Results
In this study, we have identified 12 AspRS family genes and noted that poplar acquired four PtrIBI pairs through whole genome duplication (WGD). We conducted cis-action element analysis and found a significant number of stress-related action elements on different PtrIBI genes promoters. The expression of most PtrIBI genes was up-regulated under beetle and mechanical damage stresses, indicating their potential role in responding to leaf damage stress. Our results suggest that a 50 mM BABA treatment can alleviate the damage caused by drought stress in plants. Additionally, via transcriptome sequencing, we observed that the partial up-regulation of BABA receptor genes, PtrIBI2/4/6/8/11, in poplars after drought treatment. We hypothesize that poplar responds to drought stress through the BABA-PtrIBIs-PtrVOZ coordinated ABA signaling pathway. Our research provides molecular evidence for understanding how plants respond to drought stress through external application of BABA.

Conclusions
In summary, our study conducted genome-wide analysis of the AspRS family of P. trichocarpa and identified 12 PtrIBI genes. We utilized genomics and bioinformatics to determine various characteristics of PtrIBIs such as chromosomal localization, evolutionary tree, gene structure, gene doubling, promoter cis-elements, and expression profiles. Our study found that certain PtrIBI genes are regulated by drought, beetle, and mechanical damage implying their crucial role in enhancing poplar stress tolerance. Additionally, we observed that external application of low concentrations of BABA increased plant drought resistance under drought stress. Through the BABA-PtrIBIs-PtrVOZ signaling module, poplar plants were able to transduce ABA signaling and regulate their response to drought stress. These results suggest that the PtrIBI genes in poplar have the potential to improve drought tolerance in plants through the topical application of low concentrations of BABA.
The relationship between longer leukocyte telomeres and dNCR in non-cardiac surgery patients: a retrospective analysis
Authors: Liu Chen , Ding Ke , Abdul Mannan , Sun Qing-Chun , Zhang Zhen-Feng , Dong Meng-Meng , Han Liu , Dai Ming-Sheng , Guan Hui-Lian , Han Yuan , Liu He , Chen Xue-Fen , Cao Jun-Li 
Published: August 2023

Abstract
Background
Cognitive decline following surgery is a common concern among elderly individuals. Leukocyte telomere length (LTL) can be assessed as a biological clock connected to an individual lifespan. However, the mechanisms causing this inference are still not fully understood. As a result of this, LTL has the potential to be useful as an aging-related biomarker for assessing delayed neurocognitive recovery (dNCR) and related diseases.

Methods
For this study, 196 individuals over 60 who were scheduled due to major non-cardiac surgical operations attended neuropsychological testing before surgery, followed by additional testing one week later. The finding of dNCR was based on a measured Z-score ≤ -1.96 on two or more separate tests. The frequency of dNCR was presented as the primary outcome of the study. Secondly, we evaluated the association between dNCR and preoperative LTL.

Results
Overall, 20.4% [40/196; 95% confidence interval (CI), 14.7–26.1%] of patients exhibited dNCR 1-week post-surgery. Longer LTL was identified as a predictor for the onset of early cognitive impairment resulting in postoperative cognitive decline [odds ratio (OR), 14.82; 95% CI, 4.01–54.84; P < 0.001], following adjustment of age (OR, 12.33; 95% CI, 3.29–46.24; P < 0.001). The dNCR incidence based on LTL values of these patients, the area under the receiver operating characteristic (ROC) curve was 0.79 (95% CI, 0.722–0.859; P < 0.001). At an optimal cut-off value of 0.959, LTL values offered respective specificity and sensitivity values of 64.7% and 87.5%.

Conclusions
In summary, the current study revealed that the incidence of dNCR was strongly associated with prolonged LTL. Furthermore, this biomarker could help identify high-risk patients and offer insight into the pathophysiology of dNCR.
Association between estimated pulse wave velocity and all-cause mortality in patients with coronary artery disease: a cohort study from NHANES 2005–2008
Authors: Chen Chunwei , Bao Wei , Chen Chengwen , Chen Lingyao , Wang Liudi , Gong Haibin 
Published: August 2023

Abstract
Background
Arterial stiffness has been shown to be an independent risk factor for adverse events and all-cause mortality in patients. Although PWV is the gold standard for pulse wave velocity, its application in clinical practice is limited by the high cost and complexity. ePwv is a new, simple, non-invasive indicator of arterial stiffness. The aim of this study was to assess the relationship between ePwv and all-cause mortality in patients with coronary artery disease.

Methods
This is a cohort study, selected from NHANES 2005 to 2008, 402 patients with coronary artery disease were included. The ePWV was divided into two groups and KM survival curves were used to calculate cumulative mortality in patients with coronary artery disease. Restricted cubic spline were used to represent the relationship between ePWV and all-cause mortality in patients with coronary artery disease. Cox regression was used to diagnose the relationship between ePwv and all-cause mortality.

Results
The mean age of the study subjects was 68.5 ± 11.8 years, of which 282 (70.1%) were men and 120 (29.9%) were women. During 180 months of follow-up, 160 all-cause mortality occurred. KM survival curves indicated that all-cause mortality increased with increasing ePWV. The relationship between ePWV and all-cause mortality in patients with coronary artery disease was verified by cox models. Patients in higher ePWV tertile tended to have higher all-cause mortality. After complete multivariate adjustment, an increase in ePWV was positively associated with all-cause mortality (HR = 1.180, 95% confidence interval (CI): 1.056–1.320). The multivariate-adjusted HR and 95% CI for the highest ePWV tertile was 1.582 (95% CI: 0.968–2.587) compared to the lowest tertile. In addition, the association between ePWV and mortality was visualized employing restricted spline curves, in which we found curves indicating a possible threshold for the effect of ePWV on all-cause mortality, with HR less than 1 when ePWV was less than 11.15 m/s; thereafter, there was a tendency for HR to increase with enhanced ePWV. Subgroup analysis showed that the correlation between ePWV and mortality persisted in population subgroups.

Conclusion
Our findings suggest that higher ePWV is associated with increased all-cause mortality in patients with coronary artery disease, particularly when ePWV exceeds 11.15 m/s.
The evaluation of the MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection
Authors: Negaresh Mohammad , Safarzadeh Elham , Fouladi Nasrin , Matin Somaieh , Pourfarzi Sanaz 
Published: August 2023

Abstract
Background
Helicobacter pylori (H. pylori) is one of the leading causes of peptic ulcers, and its treatment is a worldwide challenge. Matrix metalloproteinases and their inhibitors influence the development and healing of peptic ulcers. This study aimed to evaluate the ratios of matrix metalloproteinase-2 (MMP-2) to tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with peptic ulcers that are sensitive or resistant to H. pylori treatment and compare them with healthy individuals.

Methods
In this study, 95 patients were included and divided into two groups sensitive (41 patients) and resistant to treatment (54 patients). The results were compared with a control group of 20 participants with normal endoscopy and H. pylori-negative. After obtaining written informed consent, five ml of venous blood was taken to determine their serum MMP-2 and TIMP-1 levels using an enzyme-linked immunosorbent assay.

Results
In patients with H. pylori-induced peptic ulcers, the MMP-2/TIMP-1 ratio was significantly higher than the healthy controls (P < 0.05). MMP-2 level was associated with patients’ response to treatment (P < 0.05). The MMP-2/TIMP-1 ratio was higher in patients with simultaneous gastric and duodenal ulcers (P < 0.05).

Conclusion
It seems that peptic ulcer disease caused by infection with H. pylori increases the MMP-2/TIMP-1 ratio in patients with peptic ulcers. However, it might not be a good predictor of refractory H. pylori-induced peptic ulcer disease.
Gender-specific association of loneliness and health care use in community-dwelling older adults
Authors: Boehlen Friederike Hildegard , Heider Dirk , Schellberg Dieter , Hohls Johanna Katharina , Schöttker Ben , Brenner Hermann , Friederich Hans-Christoph , König Hans-Helmut , Wild Beate 
Published: August 2023

Abstract
Background
Loneliness in older adults is common, particularly in women. In this article, gender differences in the association of loneliness and health care use are investigated in a large sample of community-dwelling older adults.

Methods
Data of 2525 persons (ages 55–85 years)—participants of the fourth follow- up (2011–2014) of the ESTHER study- were analyzed. Loneliness and health care use were assessed by study doctors in the course of a home visit. Gender-specific regression models with Gamma-distribution were performed using loneliness as independent variable to predict outpatient health care use, adjusted for demographic variables.

Results
In older women, lonely persons were shown to have significantly more visits to general practitioners and mental health care providers in a three-month period compared to less lonely persons (p = .005). The survey found that outpatient health care use was positively associated with loneliness, multimorbidity, and mental illness in older women but not in older men. Older men had significantly more contact with inpatient care in comparison to women (p = .02).

Conclusions
It is important to consider gender when analyzing inpatient and outpatient health care use in older persons. In older women loneliness is associated with increased use of outpatient services.