bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacological treatment of bipolar disorder and risk of diabetes mellitus: A nationwide study of 30,451 patients
Authors: Rohde Christopher , Köhler‐Forsberg Ole , Nierenberg Andrew A. , Østergaard Søren Dinesen 
Published: February 2023

AbstractObjectiveWhile treatment with antipsychotics and antiepileptics have been associated with an increased risk of diabetes mellitus (DM), lithium may have the opposite effect via inhibition of glycogen synthase kinase‐3. The aim of this study was to investigate whether treatment of bipolar disorder with lithium, antipsychotics, or antiepileptics is associated with the risk of DM in a real‐world clinical setting.MethodsUsing nationwide registers, we identified all patients diagnosed with bipolar disorder in Danish Psychiatric Services from January 1, 1996, to January 1, 2019 (N = 30,451). The risk of developing DM was operationalized via hospital diagnoses and redeemed prescriptions for glucose‐lowering drugs. For lithium, antipsychotics, valproate, and lamotrigine, we calculated hazard rate ratios (HRR) for developing DM via adjusted Cox proportional hazards models. Potential cumulative dose–response‐like associations were examined using the log‐rank test.ResultsDuring follow‐up (245,181 person‐years), 2107 (6.9%) patients developed DM. Compared with non‐users of the respective drugs, we found no clinically or statistically significant difference in the risk of developing DM among patients receiving lithium (n = 11,690; incidence rate of DM/1000 person‐years (IR) = 8.87, 95% CI: 8.02–9.90; HRR = 0.94, 95% CI: 0.84–1.06) or lamotrigine (n = 11,785; IR = 7.58, 95% CI: 6.69–8.59; HRR = 0.89, 95% CI: 0.77–1.02), respectively. Conversely, for patients receiving valproate (n = 5171; IR = 12.68, 95% CI: 10.87–14.80; HRR = 1.34, 95% CI: 1.14–1.58) and antipsychotics (n = 22,719; IR = 12.00, 95% CI: 11.14–12.94; HRR = 1.65, 95% CI: 1.45–1.88), respectively, there was increased risk of developing DM. For antipsychotics, we observed a clear cumulative dose–response‐like association with the risk of DM.ConclusionsTreatment with valproate and antipsychotics—but not with lithium and lamotrigine—was associated with increased risk of DM in a real‐world cohort of patients with bipolar disorder.
Genomic profiling and prognostic factors of H3 K27M‐mutant spinal cord diffuse glioma
Authors: Chai Rui‐Chao , Yan Hao , An Song‐Yuan , Pang Bo , Chen Hui‐Yuan , Mu Quan‐Hua , Zhang Ke‐Nan , Zhang Yao‐Wu , Liu Yu‐Qing , Liu Xing , Zhao Zheng , Jiang Tao , Wang Yong‐Zhi , Jia Wen‐Qing 
Published: February 2023

AbstractH3 K27‐altered diffuse midline glioma is a highly lethal pediatric‐type tumor without efficacious treatments. Recent findings have highlighted the heterogeneity among diffuse midline gliomas with different locations and ages. Compared to tumors located in the brain stem and thalamus, the molecular and clinicopathological features of H3 K27‐altered spinal cord glioma are still largely elusive, thus hindering the accurate management of patients. Here we aimed to characterize the clinicopathological and molecular features of H3 K27M‐mutant spinal cord glioma in 77 consecutive cases. We found that the H3 K27M‐mutant spinal cord glioma, with a median age of 35 years old, had a significantly better prognosis than H3 K27M‐mutant brain tumors. We noticed a molecular heterogeneity of H3 K27M‐mutant spinal cord astrocytoma via targeted sequencing with 34 cases. TP53 mutation which occurred in 58.8% of cases is mutually exclusive with PPM1D (26%) and NF1 (44%) mutations. The TP53‐mutant cases had a significantly higher number of copy number variants (CNV) and a marginally higher proportion of pediatric patients (age at diagnosis <18 years old, p = 0.056). Cox regression and Kaplan–Meier curve analysis showed that the higher number of CNV events (≥3), chromosome (Chr) 9p deletion, Chr 10p deletion, ATRX mutation, CDK6 amplification, and retinoblastoma protein (RB) pathway alteration are associated with worse survival. Cox regression analysis with clinicopathological features showed that glioblastoma histological type and a high Ki‐67 index (>10%) are associated with a worse prognosis. Interestingly, the histological type, an independent prognostic factor in multivariate Cox regression, can also stratify molecular features of H3 K27M‐mutant spinal cord glioma, including the RB pathway, KRAS/PI3K pathway, and chromosome arms CNV. In conclusion, although all H3 K27M‐mutant spinal cord diffuse glioma were diagnosed as WHO Grade 4, the histological type, molecular features representing chromatin instability, and molecular alterations associated with accelerated cell proliferative activity should not be ignored in clinical management.
Gene–environment interplay linking perceived parental supervision and peer drunkenness with Chinese adolescent alcohol initiation
Authors: Zheng Yao , Meyer Zachary , Unger Jennifer B. , Rijsdijk Frühling 
Published: February 2023

AbstractFollowing 602 Chinese twin pairs (48% male, all Han ethnicity) from primarily lower‐than‐average socioeconomic status families from early to mid‐adolescence (Ms = 12 and 15 in 2006 and 2009), this study investigated gene–environment interplay between perceived parental supervision, peer drunkenness, and adolescent alcohol initiation. For alcohol initiation, shared environmental influences were initially negligible but became substantial. Genetic factors largely explained the links between both correlates with alcohol initiation. Parental supervision amplified genetic risks for alcohol initiation in early adolescence but suppressed it in mid‐adolescence. Peer drunkenness augmented genetic and environmental influences at both times. Peer drunkenness showed stronger links and moderating potential than parental supervision. Chinese adolescents show dynamic gene–environment interplay patterns involving parent–child and peer processes in alcohol initiation.
Perceived parental alcohol problems and later dropout and grade point average in high school: A register‐based follow‐up study
Authors: Pisinger Veronica Sofie Clara , Møller Sanne Pagh , Andersen Susan , Tolstrup Janne S. 
Published: February 2023

AbstractIntroductionThe aim of the study was to test the hypothesis that young people with perceived parental alcohol problems have higher dropout rates in high school and lower grade point average (GPA) at graduation compared to young people without perceived parental alcohol problems.MethodsData come from Danish National Youth Study 2014 (n = 62,171), merged with register‐data on later dropout of high school and GPA. Multilevel Poisson regression models of incidence rates of dropout and multilevel linear models of GPA were used to assess the association with perceived parental alcohol problems.ResultsA total of 6.6% of the students perceived their parent(s) to have alcohol problems. Young people with perceived parental alcohol problems had higher dropout rate (girls incidence rate ratio 1.83; 95% confidence interval [1.62–2.06]); boys (incidence rate ratio 1.38; 95% confidence interval [1.17–1.64]) and lower grades (GPA: −0.24; 95% confidence interval [−0.32; −0.17]) compared to those without. There was no statistically significant difference between mother's and fathers' alcohol problems in the associations with dropout and GPA.Discussion and ConclusionsPerceived parental alcohol problems were associated with higher incidence rate ratio of dropout and lower grades within all categories of the socioeconomic factors. Our results show that young people with perceived parental alcohol problems have higher high school dropout rates and lower grades compared to those without perceived parental alcohol problems across gender and socioeconomic position. The results call for evidence‐based interventions to support young people with parental alcohol problems in the educational system.
Prediabetes and the risk of type 2 diabetes: Investigating the roles of depressive and anxiety symptoms in the Lifelines cohort study
Authors: Deschênes Sonya S. , McInerney Amy , Nearchou Finiki , Byrne Brendan , Nouwen Arie , Schmitz Norbert 
Published: February 2023

AbstractAimsDepression and anxiety may increase the risk of progressing from prediabetes to type 2 diabetes. The present study examined the interactions between prediabetes status and elevated depressive and anxiety symptoms with the risk of type 2 diabetes.MethodsParticipants (N = 72,428) were adults aged 40 years and above without diabetes at baseline from the Lifelines Cohort Study (58% female; mean age = 51.4 years). The Mini‐International Neuropsychiatric Interview screened for elevated symptoms of major depressive disorder and generalized anxiety disorder. Glycated haemoglobin A1c (HbA1c) levels determined prediabetes status at baseline (2007–2013), and HbA1c and self‐reported diabetes diagnoses determined diabetes status at follow‐up (2014–2017). Groups were formed for elevated depressive and anxiety symptoms, respectively, and prediabetes status at baseline (elevated depressive/anxiety symptoms with prediabetes, elevated depressive/anxiety symptoms alone, and prediabetes alone), and compared to a reference group (no prediabetes or anxiety/depression) on the likelihood of developing diabetes during the follow‐up period.ResultsN = 1300 (1.8%) participants developed diabetes. While prediabetes alone was associated with incident diabetes (OR = 5.94; 95% CI = 5.10–6.90, p < 0.001), the group with combined prediabetes and depressive symptoms had the highest likelihood of developing diabetes over follow‐up (OR = 8.29; 95% CI = 5.58–12.32, p < 0.001). Similar results were found for prediabetes and anxiety symptoms (OR = 6.57; 95% CI = 4.62–9.33, p < 0.001), compared to prediabetes alone (OR = 6.09; 95% CI = 5.23–7.11, p < 0.001), though with a smaller effect. The interaction between depressive symptoms and prediabetes was synergistic in age‐and‐sex adjusted analyses.ConclusionsIndividuals with elevated depressive, and to some extent anxiety, symptoms in combination with prediabetes may represent a high‐risk subgroup for type 2 diabetes.
Decreased β‐hydroxybutyrate and ketogenic amino acid levels in depressed human adults
Authors: Sato Shiho , Yu Zhiqian , Sakai Mai , Motoike Ikuko N. , Saigusa Daisuke , Hirayama Ryo , Kikuchi Yoshie , Abe Takaaki , Kinoshita Kengo , Koshiba Seizo , Tomita Hiroaki 
Published: February 2023

Abstractβ‐hydroxybutyrate (BHB) is a major ketone body synthesized mainly in the liver mitochondria and is associated with stress and severity of depression in humans. It is known to alleviate depressive‐like behaviors in mouse models of depression. In this study, plasma BHB, ketogenic and glucogenic amino acids selected from the Tohoku Medical Megabank Project Community‐Based Cohort Study were analysed and measured using nuclear magnetic resonance spectroscopy. The Center for Epidemiologic Studies Depression Scale (CES‐D) was utilized to select adult participants with depressive symptoms (CES‐D ≥ 16; n = 5722) and control participants (CES‐D < 16; n = 18,150). We observed significantly reduced plasma BHB, leucine, and tryptophan levels in participants with depressive symptoms. Using social defeat stress (SDS) mice models, we found that BHB levels in mice sera increased after acute SDS, but showed no change after chronic SDS, which differed from human plasma results. Furthermore, acute SDS increased mitochondrial BHB levels in the prefrontal cortex at 6 h. In contrast, chronic SDS significantly increased the amount of food intake but reduced hepatic mitochondrial BHB levels in mice. Moreover, gene transcriptions of voltage‐dependent anion‐selective channel 1 (Vdac1) and monocarboxylic acid transporter 1 (Mct1), major molecules relevant to mitochondrial biogenesis and BHB transporter, significantly decreased in the liver and PFC after chronic SDS exposure. These results provide evidence that hepatic and prefrontal mitochondrial biogenesis plays an important role in BHB synthesis under chronic stress and in humans with depressive symptoms.
Brand relationships in wireless mobile environments: The mediating role of apps
Authors: Garcia‐Davalos Alexander , Garcia‐Duque Jorge 
Published: February 2023

AbstractBrands use branded mobile apps to interact with users and to develop brand relationships in wireless mobile environments. These apps collect data about users and app usage, which are potentially helpful for brand relationship research. We aim to contribute to understanding the user–brand relationship (UBR) measurement mediated by branded apps, an area with very limited research, with a focus on leveraging these apps as a gauging context to measure the UBR strength. We propose a data‐driven model to measure the UBR strength that combines metrics computed by using branded app data with close interpersonal relationship indicators. We conducted a computer simulation to test the proposed model. Our findings show that app usage time is the metric that most affects UBR strength measurement. The results suggest that time is essential for developing brand relationships in wireless mobile environments, much like in interpersonal relationships. The proposed model can be supplemented with other metrics to study new attributes associated with the UBR that might emerge in these environments.
Desirability–doability group judgment framework for the collaborative multicriteria evaluation of public policies
Authors: Bana e Costa Carlos A. , Oliveira Mónica D. , Rodrigues Teresa C. , Vieira Ana C.L. 
Published: February 2023

AbstractDesirability–doability framework (2 × D) is a novel framework for the collaborative evaluation of public policies. Fundamental objectives and performance indicators are agreed upon in workshops, policies are characterised, and barriers to implementation identified. MACBETH interactive protocols are then applied in decision conferences to elicit qualitative judgments about the desirability of policies, within and across objectives; and about their doability under the expected graveness of barriers on contrasting scenarios. Elicited judgments allow, respectively, to construct a shared multicriteria model measuring the overall desirability of policies; and, to measure their doability. Desirability–doability graphs enable visual interactive classification of policies, with sensitivity/robustness analyses of uncertainties. 2 × D was successfully tested in a real‐world urban‐health policymaking case to evaluate spatial policies. The main novelty of 2 × D is that it bridges the socio‐technical gap, present in OR, between the support required by a complex social decision‐making process, and that usually offered by analytic techniques – while keeping modeling theoretically sound and simple.
Clarification on phase transition behaviors by local strain engineering in Bi1/2Na1/2TiO3–SrTiO3‐based ternary ceramics
Authors: Nguyen Hoang Thien Khoi , Duong Trang An , Ahn Chang Won , Kim Byeong Woo , Han Hyoung‐Su , Lee Jae‐Shin 
Published: February 2023

AbstractThe stabilization of ergodicity plays an important role in realizing large strain in a Bi1/2Na1/2TiO3 (BNT)‐based relaxor, which is strongly related to the degree of random fields with respect to the randomly distributed different cations. To clarify the effects of different ionic radii, this study investigated and compared the microstructures, crystal structures, phase transition behaviors, and electrical properties of BNT–ST‐based ternary ceramics by modifying BiMeO3 (where Me = Al and Fe). It was observed that the stabilized relaxor states are different between BiFeO3‐/and BiAlO3‐modified BNT–ST ternary ceramics. As a result, it is suggested that phase transition (more precisely, the stabilization of ergodicity) can be influenced by the different internal strain in BNT–ST‐based ternary ceramics.
Investigating the impact of a virtual reality mobile application on learners' interpreting competence
Authors: Chan Venus 
Published: February 2023

AbstractBackgroundThis research is inspired by the challenges encountered in interpreter training, changes in learning needs in the technological era, the educational paradigm shift caused by the COVID‐19 pandemic, the lack of studies on combining virtual reality (VR)_and mobile technologies, and literature gaps in the field of the incorporation of technology in interpreter education.ObjectivesThis research aims to develop a mobile‐based VR application for bi‐directional English‐Chinese and Chinese‐English interpreting learning named ‘Virtual Interpreting Practice’ (VIP) based on an interpreting competence model and to investigate its impact on students' self‐rated language and interpreting proficiency levels as well as their declarative knowledge and operative skills as reflected in different interpreting modes (sight and consecutive) and language directions (English‐Chinese and Chinese‐English). The VIP app contains learning resources, including 13 learning modules covering both interpreting modes, practical topics and contexts, video lectures and demonstrations, fully immersive VR and non‐VR practice, glossary lists, source texts, translated texts and an online feedback platform.MethodsThirty‐one native Chinese‐speaking English as a second/foreign (ESL/EFL) undergraduate students used the app for self‐directed learning. The data were collected by the pre‐study and post‐study questionnaires as well as the pre‐test and post‐test.Results and ConclusionsThe results indicate that the use of VIP significantly raised the students' self‐rated language and interpreting proficiency levels as well as their interpreting performance in both modes and language directions. While the students performed better in sight interpreting and Chinese‐English interpreting, they achieved a significantly higher improvement rate in consecutive interpreting and English‐Chinese interpreting.
A Model of Systemic Bank Runs
Authors: LIU XUEWEN 
Published: February 2023

ABSTRACTWe develop a tractable model of systemic bank runs. The market‐based banking system features a two‐layer structure: banks with heterogeneous fundamentals face potential runs by their creditors while they trade short‐term funding in the asset (interbank) market in response to creditor withdrawals. The possibility of a run on a particular bank depends on its assets' interim liquidation value, and this value depends endogenously in turn on the status of other banks in the asset market. The within‐bank coordination problem among creditors and the cross‐bank price externality feed into each other. A small shock can be amplified into a systemic crisis.
Relations between social withdrawal subtypes and socio‐emotional adjustment among Chinese children and early adolescents
Authors: Ding Xuechen , Zhang Wen , Ooi Laura L. , Coplan Robert J. , Zhu Xinyi , Sang Biao 
Published: February 2023

AbstractThe aim of the present study was to compare the relations between subtypes of social withdrawal and socio‐emotional adjustment in Chinese children and early adolescents. Participants included 571 children (Mage = 9.62 years) and 345 adolescents Mage = 12.12 years) in mainland China. Social withdrawal subtypes (i.e., shyness, unsociability, social avoidance) and indices of socio‐emotional adjustment were assessed via self‐reports, peer nominations, and teacher ratings. Shyness tended to be more strongly associated with emotional maladjustment in early adolescence, whereas unsociability was more strongly associated with socio‐emotional difficulties in childhood. For social avoidance, associations with indices of negative adjustment (i.e., social anxiety, emotional symptoms, peer problems) were stronger in childhood, however, associations with indices of positive adjustment (i.e., life satisfaction, well‐being) were stronger in early adolescence.
A perceived control‐relationally devaluing experiences model of low socioeconomic status vulnerability to negative relationship outcomes
Authors: Petsnik Corey , Vorauer Jacquie D. 
Published: February 2023

AbstractWe propose that individuals low (vs. high) in socioeconomic status (SES) are vulnerable to impaired relationship functioning through two different mutually reinforcing paths that both directly implicate perceptions of control and relational devaluation. The first of these involves chronic exposure to relational devaluation as a function of factors such as stigmatization in broader society that serves to undermine low SES individuals’ perceptions of control. The second involves enhanced reactivity to relationally devaluing experiences such as discrimination and ostracism as a function of this limited reserve of perceived control. We present a perceived control‐relationally devaluing experiences model of low SES vulnerability to impaired relationship functioning that incorporates these predictions and further specifies how low SES individuals’ reduced perceptions of control may help account for documented associations between low SES and negative interpersonal outcomes such as hostility, aggression, and reduced relationship quality. We conclude by considering implications for intervention as well as potential alternative and complementary mechanisms.
Plant phenology and species‐specific traits control plant CH4 emissions in a northern boreal fen
Authors: Ge Mengyu , Korrensalo Aino , Laiho Raija , Lohila Annalea , Makiranta Päivi , Pihlatie Mari , Tuittila Eeva‐Stiina , Kohl Lukas , Putkinen Anuliina , Koskinen Markku 
Published: February 2023

Summary
Aerenchymatic transport is an important mechanism through which plants affect methane (CH4) emissions from peatlands. Controlling environmental factors and the effects of plant phenology remain, however, uncertain.
We identified factors controlling seasonal CH4 flux rate and investigated transport efficiency (flux rate per unit of rhizospheric porewater CH4 concentration). We measured CH4 fluxes through individual shoots of Carex rostrata, Menyanthes trifoliata, Betula nana and Salix lapponum throughout growing seasons in 2020 and 2021 and Equisetum fluviatile and Comarum palustre in high summer 2021 along with water‐table level, peat temperature and porewater CH4 concentration.
CH4 flux rate of C. rostrata was related to plant phenology and peat temperature. Flux rates of M. trifoliata and shrubs B. nana and S. lapponum were insensitive to the investigated environmental variables. In high summer, flux rate and efficiency were highest for C. rostrata (6.86 mg m−2 h−1 and 0.36 mg m−2 h−1 (μmol l−1)−1, respectively). Menyanthes trifoliata showed a high flux rate, but limited efficiency. Low flux rates and efficiency were detected for the remaining species.
Knowledge of the species‐specific CH4 flux rate and their different responses to plant phenology and environmental factors can significantly improve the estimation of ecosystem‐scale CH4 dynamics in boreal peatlands.
Measuring Poverty Dynamics with Synthetic Panels Based on Repeated Cross Sections
Authors: Dang Hai‐Anh H. , Lanjouw Peter F. 
Published: February 2023

AbstractPanel data are rarely available for developing countries. Departing from traditional pseudo‐panel methods that require multiple rounds of cross‐sectional data to study poverty mobility at the cohort level, we develop a procedure that works with as few as two survey rounds and produces point estimates of transitions along the welfare distribution at the more disaggregated household level. Validation using Monte Carlo simulations and real cross‐sectional and actual panel survey data – from several countries, spanning different income levels and geographical regions – perform well under various deviations from model assumptions. The method could also inform investigation of other welfare outcome dynamics.