bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of endothelial function indexes in patients with post-Covid syndrome using a combination drug of ethylmethylhydroxyperidine succinate/vitamin B6
Authors: Mikhailova Larisa V. , Belousova Yana D. , Moiseeva Ekaterina M. , Tsapkova Alina A. , Gazatova Natalya D. , Plotnikova Alexandra R. , Rudev Danila G. , Doktorova Svetlana A. , Rafalskiy Vladimir V. 
Published: May 2023

Introduction: After the COVID-19 pandemic, public healthcare has faced a new problem, the persistence of symptoms, the most significant of which is undue fatigue. The definition of coronavirus infection as an endothelial disease suggests a possible relationship between asthenic syndrome and endothelial dysfunction.
Aim: to evaluate endothelial function in patients after COVID-19 before and after treatment with combination drug of ethylmethylhydroxyperidine succinate (EMHPS)/vitamin B6.
Materials and Methods: A prospective study included 33 participants, 82% women and 18% men aged 22 to 68 years after COVID-19. There were two site visits made in the course of the study and a 4-week treatment course between the visits.
Results: After the treatment, the index of endothelium-dependent vasodilation increased in women and decreased in men. The differences were statistically insignificant. The number of subjects with a normal level of endothelium-dependent vasodilation increased from 7 to 11 after the treatment. The index of vascular wall stiffness corresponded to the mean age of the examined participants and did not statistically change, although women tended to decrease stiffness and men to increase it. The initial level of nitric oxide was lower in women and statistically significantly increased after treatment, while it remained unchanged in men.
Discission: The study confirms a prolonged course of the post-covid. We assume that the virus destroys endothelial cells.Endothelial dysfunction is known to be associated with an increased cardiovascular risk.
Conclusion: The indicators of endothelial function changed in patients after treatment with the drug. It is necessary to perform endothelial function studies in more patients after COVID-19.
Graphical Abstract
AÇÃO DECLARATÓRIA DE CONSTITUCIONALIDADE Nº 41/2017: AS COTAS PARA NEGROS EM FOCO
Authors: Machado Maricelia Cristiam Lopes 
Published: May 2023

A constitucionalidade da Lei de cotas para negros em concursos públicos é cenário de debates, discussões e controvérsias, acerca do Tema. O assunto é tratado na Lei 12.990/2014. Em 2016 o Conselho Federal da OAB ajuizou ação declaratória de constitucionalidade (ADC nº 41) em defesa da Lei nº 12.990/2014 pedindo que o STF declarasse esta norma compatível com a CF/88. Em 2017 o STF julgou procedente a ADC, declarando a constitucionalidade da Lei nº 12.990/2014. Desde a entrada em vigor da mencionada Lei que obriga a Administração Pública Federal de todos os poderes da União a reservarem vagas aos candidatos negros, vários concursos Federais já foram realizados e finalizados e previram nos seus editais as reservas de 20% das vagas ofertadas nos certames. Nesse contexto, surge o presente trabalho, que tem como escopo primordial disseminar informações fundamentadas à comunidade acadêmica, acerca da ação afirmativa de reserva de vagas para negros em concursos públicos e discutir por que houve a necessidade de se arguir pela Declaração de Constitucionalidade da Lei de Cotas para concurso Público. E ainda, se há a necessidade de Lei de Cotas no Brasil. Se é possível excepcionalizar o principio da igualdade constitucional, caso positivo, sob qual fundamento e também discutir sobre quais as dificuldades enfrentadas ainda hoje em relação às cotas nos concursos públicos. A metodologia utilizada foi a pesquisa bibliográfica em fontes primarias e secundárias.
Small Values and Chung's Laws of the Iterated Logarithm for Spatial Surface of Operator Fractional Brownian Motion
Authors: Wang Wensheng 
Published: May 2023

The multivariate Gaussian random fields with matrix-based scaling laws are widely used for inference in statistics and many applied
areas. In such contexts interests are often in symmetry and in the rates of change of spatial surfaces in any given direction. This article analyzes the almost sure sample function behavior for operator fractional Brownian motion, including multivariate fractional Brownian motion. We obtain the estimations of small ball probability and the strongly locally nondeterministic for operator fractional Brownian motion in any given direction. Applying these estimates we obtain Chung&#039;s laws of the iterated logarithm for spatial surfaces of operator fractional Brownian motion. Our results show that the precise rates of change of spatial surfaces are completely determined by the self-similarity exponent.
Validation of a Newly Diagnosis Model of Dynamical Electromyography Network for Neuromuscular Tracing in Hemiplegic Ankle-Foot Motor Dysfunctions
Authors: Xu Ying , Geng Canru , Li Jinping , Guan Juntao , Tang Tong , Hou Ying , Guo Aisong 
Published: May 2023

Abstract
Background: The rating scales cannot locate and quantitatively identify muscles responsible for ankle-foot motor dysfunctions in hemiplegia patients.
Object: To trace calf muscles responsible for neuromuscular dysfunction in hemiplegia patients, using a newly designed diagnosis model of dynamical surface electromyography (sEMG) network.
Methods: Observe the characteristics of eight groups of muscles in bilateral calves in 14 male patients with hemiplegia and 10 age- and sex-matched healthy adults in static standing position, with two linear indices, root mean square (RMS) and median frequency (MF), and five nonlinear network indices, average interlayer mutual information (I), average edge overlap (ω), clustering coefficient (C), average shortest path length (L), and degree centrality (DC).
Results: The RMS of the anterior tibialis (AT), medial gastrocnemius (MG), soleus (SOL) on the affected sides was lower than those on the other sides (P<.05). The MF of the extensor digitorum longus (EDL) on the affected sides was significantly lower than that of the unaffected sides and control groups (P<.05).I, W, and C of the unaffected side were significantly higher than those of the affected sides and the control group, whereas L was lower (P<.05). Compared to the control group, the DC of the AT and EDL on the unaffected sides were higher (P < .05), and that of the MG on the affected sides was lower (P<.05).
Conclusion: In this study, the affected EDL was diagnosed as a passive eccentric muscle, and the gastrocnemius and FDL were prone to paralysis, and in which the FDL was accompanied by hyperresponsiveness. The diagnosis of pathological muscles conditions was accordance with characteristics of muscle conditions of ankle-foot motor dysfunctions in hemiplegia patients. Therefore, the newly designed diagnosis system may locate and quantitatively identify muscles responsible for hemiplegia patients, and the targeted treatments for these muscles might be carried out accurately.
Clinical trial registration number: ChiCTR2100055090.
Simulation and Parametric Optimization of Controller for Three-Link Robotic Manipulator in Casting
Authors: Jangid Mahendra Kumar , Kumar Sunil , Singh Jagtar , Abualigah Laith 
Published: May 2023

Abstract
In this study, a simulation of a three-link robotic manipulator has been analyzed for pouring liquid metal during casting. The robotic manipulator is controlled by a proportional integral derivative (PID) controller, a tilt integral derivative (TID) controller, and a fractional-order proportional integral derivative (FOPID) controller. The controller parameters are optimized by a novel meta-heuristic nature-inspired optimization algorithm called grey wolf optimization (GWO), and a comparative analysis is performed with particle swarm optimization (PSO). This robotic manipulator has been designed in SolidWorks and simulated in MATLAB Simulink/sim-mechanics environment. The end-effector trajectory during the casting and comparative joint trajectory has been studied. The FOPID controller optimized by GWO shows better results by giving less integral time absolute error (ITAE) compared with FOPID-PSO and other controllers. Numerically GWO decreases the error by 3.85%, 9.09%, and 41.89% using PID, TID, and FOPID controller respectively as compared to PSO.
Evolved bacterial siderophore-mediated antibiotic cross-protection
Authors: Jorth Peter , Galdino Anna Clara , Vaillancourt Mylene , Celedonio Diana , Huse Kara , Doi Yohei , Lee Janet 
Published: May 2023

Abstract
Antibiotic cross-protection enables resistant bacteria to protect other bacteria that would be otherwise susceptible to the drug. Cefiderocol is the first siderophore cephalosporin antibiotic approved for treating Gram-negative bacterial infections, including carbapenem-resistant Pseudomonas aeruginosa strains. While highly effective, CFDC resistance has been detected clinically, and mechanisms of resistance and cross-protection are not completely understood. In this study, we used experimental evolution and whole genome sequencing to identify cefiderocol resistance mechanisms and evaluated the trade-offs of evolving resistance. We found some cefiderocol-resistant populations evolved cross-protective social behavior, preventing cefiderocol killing of susceptible siblings. Notably, cross-protection was driven by increased secretion of bacterial iron-binding siderophores, which is unique from previously described antibiotic degradation mediated cross-protection. While concerning, we also showed that resistance can be selected against in drug-free environments. Deciphering the costs associated with antibiotic resistance might aid the development of evolution-informed therapeutic approaches to delay the evolution of antibiotic resistance.
Mitochondrial double-stranded RNAs activates PKR to promote nucleus pulposus pyroptosis and intervertebral disc degeneration during metabolic stress
Authors: Guo Wei , Mu Kun , Li Wen-Shuai , Gao Shun-Xing , linfeng wang , Zhao Jian-Yong , Li Xiao-Ming 
Published: May 2023

Abstract
Intervertebral disc (IVD) degeneration is a common concomitant disease in obesity patients, but the mechanism remains largely unknown. Obsity is a metabolic syndrome that results in the concentrations of circulating lipids increased and metabolic stress. Therefore, pathways that integrate metabolic stress and nucleus pulposus (NP) cell death are of especially important in exploring the mechanisms of IVD degeneration. Here we present evidence that double-stranded RNA-dependent protein kinase (PKR) activates inflammasome and NP cell pyroptosis by sensing mt-dsRNA signals released by mitochondrial damage under metabolic stress, thus promoting the occurrence of IVD degeneration. And PKR deficiency alleviates IVD degeneration caused by metabolic stress in mice. Moreover, metformin prevents PKR activation and protects NP cells partly by attenuating mitochondria damage from metabolic stress. This research presents a comprehensive understanding of innate immune activation mediate by mt-dsRNA-PKR axis in NP cells that underlie the development of IVD degeneration during metabolic stress and recommends metformin as a therapeutic drug for treating IVD degeneration.
Public Health Crisis of Anemia in India: Retrospective Study of Hemoglobin Levels and Impact of Medication Intervention in a School Setting
Authors: Bansal Riya , Frank Aaron , Madhani Smeet , Aledia Anna , Park Drew , Kundaria Bhanji , Bera Rimal , Bera Kevin , Amin Alpesh 
Published: May 2023

Abstract
Background
Anemia has been a pervasive and constant public health crisis in India. Anemia’s prevalence in rural areas is 79% in children and 49.5% in women. A large survey of adolescent girls reported an anemia prevalence of 89%, of which 56% have iron deficiency anemia. The objectives of this study are to understand the prevalence of iron deficiency anemia in children and women from rural villages in India and the impact of a medication and health education intervention on hemoglobin levels, utilizing an existing local community structure of a boarding school.
Methods
Retrospective study of de-identified hemoglobin data originally collected during a public health clinical care investigation was performed to understand the prevalence of anemia in women and children in rural villages. Participants gave blood samples to measure hemoglobin levels. Analysis of health education and medication intervention consisting Albendazole 200 mg and Autrin Capsule tablets containing cyanocobalamin vitamin B12 (0.1% in gelatin), ferrous fumarate (98.6 mg of elemental iron), and folic acid with lemon water given to 275 female students at Kaneria Boarding School was performed to understand the impact of intervention on hemoglobin levels.
Key Results
Utilizing the World Health Organization (WHO) anemia classification, prevalence of moderate and severe anemia ranged 20-60% amongst women and children. Results from an interventional study showed a statistically and clinically significant increase in hemoglobin levels of 2.848 (p<0.05) in 10th grade and 2.423 (p<0.05) in 12th grade students.
Conclusions
Understanding the prevalence of anemia in rural regions in India is imperative to focusing therapies targeting iron deficiency anemia. Results of an interventional study utilizing existing community structures such as a school holds promise for future wide-scale iron deficiency anemia interventions.
Socio-economic contributions and challenges of urban agriculture practice in Ethiopia
Authors: Gibtan Ashagrie , Abera Wondosen , Delelegn Mekuria , Maru Molla , Emiru Adamu 
Published: May 2023

Abstract
The study was conducted to make situational analysis of UA and its implication for socioeconomic improvement for urbanites in Addis Ababa and other four selected regional towns of Bahir Dar, Hawas, Adama and Bishoftu. The study also tried to draw policy implications for demystifying UA in Ethiopia. On the other hand both primary and secondary data was accessed through questionnaire, key informant interviews, focus group discussions and field observation and reviews of published and unpublished materials. The findings of this study show that, urban agriculture benefits the urban residents in general and the practitioners in particular in different was. UA member households are able to have access to fresh and nutrient-dense food and greater dietary diversity. This implies that UA practice has a significant contribution in improving the food security of the UA farmers. The study also indicated that UA practice in Ethiopia has a significant contribution in enhancing practionners income and in turn improving living standard.
Transcriptome analysis of Long non-coding RNAs altered in sciatic nerves of aging SD rats
Authors: Wu Guanggeng , Kuang Rui , Zhang Yi , Zhu Zhaowei , Xu Shuqia , Liu Xiangxia , Xu Yangbin , Luo Yunxiang 
Published: May 2023

Abstract
Objectives
To investigate the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) changes in the sciatic nerve (SN) in Sprague Dawley (SD) rats during aging.
Methods
Eighteen healthy SD rats were selected at the age of 1 month (1M) and 24 months (24M) and SNs were collected. High-throughput transcriptome sequencing and bioinformatics analysis were performed. Protein-protein interaction (PPI) networks and competing endogenous RNA (ceRNA) networks were established according to differentially expressed genes (DEGs).
Result
As length of lncRNAs increased, its proportion to the total number of lncRNAs decreased. A total of 4079 DElncRNAs were identified in Con vs 24M. GO analysis were primarily clustered in nerve and lipid metabolism, extracellular matrix, and vascularization related fields. There were 17 nodes in the PPI network of the target genes of up-regulating genes including Itgb2, Lox, Col11a1, Wnt5a, Kras, etc. Using quantitative RT-PCR, microarray sequencing accuracy was validated. And there were 169 nodes constructing the PPI network of down-regulated target genes, mainly including Col1a1, Hmgcs1, Hmgcr. CeRNA interaction networks were constructed.
Conclusion
Lipid metabolism, angiogenesis and ECM fields might play an important role in senescence process in SNs. Col3a1, Serpinh1, Hmgcr, Fdps could be candidates for nerve aging research.
Study on grain production efficiency and its influencing factors in the Yangtze River Economic Belt based on grey water footprint
Authors: Wei Shenghui , Wang Mengwei , Zhang Degang 
Published: May 2023

Abstract
Water is the key to grain production, and water pollution is an increasingly serious constraint on grain production. Based on the grey water footprint theory, this paper constructed an super-efficient SBM model containing unexpected output to measure the grain production efficiency of 110 cities in the Yangtze River Economic Belt from 2006 to 2020. The Dagum Gini coefficient and kernel density estimation methods were used to investigate its dynamic evolution trend, and the driving factors were analyzed by the spatial econometric model. The findings are as follows: (1) The overall level of grain production efficiency in the Yangtze River Economic Belt is not high, showing a trend of first fluctuating growth and then decreasing during the sample period. (2) There are differences in the distribution dynamics of grain production efficiency in the three regions of the Yangtze River Economic Belt, with the largest difference in grain production efficiency in the upper reaches, followed by the lower reaches and the middle reaches of the Yangtze River. (3) There is a spatial spillover effect of grain production efficiency in the Yangtze River Economic Belt, but the overall coordinated development is not strong, and the driving effect of high-efficiency cities on the grain production efficiency of low-efficiency cities is not enough. (4) Economic and financial development plays a significant role in promoting grain production efficiency in the Yangtze River Economic Belt, while fiscal support for agriculture has a negative impact. Finally, the paper puts forward some suggestions to improve grain production efficiency in the Yangtze River Economic Belt.
Characterization and seismic hazard in the Coquimbo Region, Chile: A probabilistic study
Authors: Ojeda Valentina , Vega-Jorquera Pedro , Barra Erick , Palma-Chilla Luis , Vidal Luis , Saavedra José , Pizarro Alfredo 
Published: May 2023

Abstract
In order to characterize seismically the Coquimbo Region, Chile, data from 1943 to 2020 were considered. The region was divided into 30 zones of 0.5 • latitude and 0.5 • longitude and the non-extensive statistical physics was used. Both, the Sotolongo-Costa-Posadas and Mathai models were proposed to analyze the magnitude-frequency distribution. The subdivision into cells of the catalog allowed to demonstrate that systems with value of q ∼ 1 present exponential behavior, while with the superposition of subsystems it was expected to obtain q > 1, supporting the su-perstatistical model. Thus, by subdividing the Coquimbo region into the South and North regions, we find that in both the entropic index is greater than one, q > 1, however , according to the value obtained, in the southern sector the long-range effects are greater than in the northern sector. This means that both sectors ae well described by the nonextensive statistical model, either by SCP model or Mathai model; the entropic index is q > 1 and in both cases R 2 > 0.99. As the Coquimbo region is considered as a all, the nonextensive statistical distribution is the more adequated. With respect to the probabilistic seismic hazard assessment, we showed that the Mathai’s model has the better fit. Thus, in the frequency-interevent time distribution was used for different limite magnitudes values. Our analysis shows that the probability occurrence of an seismic event in the northern sector of the region is lower than in the southern sector for the same period; in the former the behavior is of Poissonian type. Thus, the region’s northern and southern zones show different behaviors in terms of earthquake occurrence probability.
3D-Printed helmet-type Neuro-navigation approach (I-Helmet) for transcranial magnetic stimulation
Authors: Wang He , Cui Dong , Jin Jingna , Wang Xin , Li Ying , Liu Zhipeng , Yin Tao 
Published: May 2023

Abstract
Neuro-navigation is a key technology to ensure the clinical efficacy of TMS. However, the neuro-navigation system based on positioning sensor is currently unable to be promoted and applied in clinical practice due to its time-consuming and high-cost. In the present study, we designed I-Helmet system to promote an individualized and clinically friendly neuro-navigation approach to TMS clinical application. I-Helmet system is based on C + + with a graphical user interface that allows users to design a 3D-printed helmet model for coil navigation. Besides, a dedicated coil positioning accuracy detection method was promoted based on three-dimensional (3D) printing and 3D laser scanning for evaluation. T1 images were collected from 24 subjects, and based on each image, phantom were created to simulate skin and hair. Six 3D-printed helmets with the head positioning hole enlarged by 0–5% tolerance in 1% increments were designed to evaluate the influences of skin, hair, and helmet-tolerance on the positioning accuracy and contact force of I-Helmet. Finally, I-Helmet system was evaluated by comparing its positioning accuracy with three skin hardnesses, three hair styles, three operators, and with or without landmarks. The accuracy of the proposed coil positioning accuracy detection method was about 0.30 mm in position and 0.22° in orientation. Skin and hair had significant influences on positioning accuracy (p < 0.0001), whereas different skin hardnesses, hair styles, and operators did not (p > 0.05). The tolerance of the helmet presented significant influences on positioning accuracy (p < 0.0001) and contact force (p < 0.0001). The positioning accuracy significantly increased (p < 0.0001) with landmark guided I-Helmet. 3D-printed helmet-type Neuro-navigation approach (I-Helmet) with 3% tolerance and landmarks met the positioning requirements for TMS in clinical practice with less than 5 N mean contact force, 3–5 mm positioning accuracy, 65.7 s mean operation time, and 50-yuan material cost.
Android-based Home Security Application
Authors: Sukri Khairul Amin Bin Mohamad 
Published: May 2023

Abstract
As the development of technology keeps on growing rapidly, the use of smart technology in our daily life is getting demand. The Android-based Home Security Application was developed to ease users to know the current situation regarding their house at any time they want especially when they are away from home. This project uses a motion detection sensor to detect a moving entity in the area where the system is deployed. The motion detection sensor and alarm system that is implemented in the application system will enable users to know the real situation that may happen at that time. As a result of the project, the user can use the application to view the current situation of their house and an alert message will be notified via the application system if a motion is detected especially when they are away. It is to ensure the users know the current situation in their house. In terms of security, the combination of the motion sensor and alarm system in this project may be more reliable and secure with the neat and straightforward user interface that may ease users to navigate around the application system.