bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graded chronic pain scale revised: validation in a Veteran sample
Authors: Taub Chloe , Gordon Kirsha S , Goulet Joseph , Lee Allison , Mayhew Meghan , Von Korff Michael , DeBar Lynn , Kerns Robert D 
Published: May 2023

Abstract

Objective
The Graded Chronic Pain Scale (GCPS) is frequently used in pain research and treatment to classify mild, bothersome, and high impact chronic pain. This study’s objective was to validate the revised version of the GCPS (GCPS-R) in a US Veterans Affairs (VA) healthcare sample to support its use in this high-risk population.

Methods
Data were collected from Veterans (n = 794) via self-report (GCPS-R and relevant health questionnaires) and electronic health record extraction (demographics and opioid prescriptions). Logistic regression, adjusting for age and gender, was used to test for differences in health indicators by pain grade. Adjusted odds ratio (AOR) with 95% confidence intervals (CIs) were reported with CIs not including an AOR of 1 indicating that the difference exceeded chance.

Results
In this population, the prevalence of chronic pain (pain present most or every day, prior 3 months) was 49.3%: 7.1% with mild chronic pain (mild pain intensity and lower interference with activities); 23.3% bothersome chronic pain (moderate to severe pain intensity with lower interference); and 21.1% high impact chronic pain (higher interference). Results of this study mirrored findings in the non-VA validation study; differences between bothersome and high impact were consistent for activity limitations and present but not fully consistent for psychological variables. Those with bothersome chronic pain or high impact chronic pain were more likely to receive long-term opioid therapy compared to those with no/mild chronic pain.

Conclusions
Findings highlight categorical differences captured with the GCPS-R, and convergent validity supports use of the GCPS-R in US Veterans.
Revision to the musculoskeletal domain of the BILAG-2004 index to incorporate ultrasound findings
Authors: Sandler Robert D , Vital Edward M , Mahmoud Khaled , Prabu Athiveeraramapandian , Riddell Claire , Teh Lee-Suan , Edwards Christopher J , Yee Chee-Seng 
Published: May 2023

Abstract

Objectives
To improve the definitions of inflammatory arthritis within the musculoskeletal (MSK) domain of the BILAG-2004 index by incorporating imaging findings and clinical features predictive of response to treatment.

Methods
The BILAG MSK Subcommittee proposed revisions to the BILAG-2004 index definitions of inflammatory arthritis, based on review of evidence in two recent studies. Data from these studies were pooled and analysed to determine the impact of the proposed changes on the severity grading of inflammatory arthritis.

Results
The revised definition for severe inflammatory arthritis includes definition of ‘basic activities of daily living’. For moderate inflammatory arthritis, it now includes synovitis, defined by either observed joint swelling or MSK US evidence of inflammation in joints and surrounding structures. For mild inflammatory arthritis, the definition now includes reference to symmetrical distribution of affected joints and guidance on how US may help re-classify patients as moderate or no inflammatory arthritis. Data from two recent SLE trials were analysed (219 patients). A total of 119 (54.3%) were graded as having mild inflammatory arthritis (BILAG-2004 Grade C). Of these, 53 (44.5%) had evidence of joint inflammation (synovitis or tenosynovitis) on US. Applying the new definition increased the number of patients classified as moderate inflammatory arthritis from 72 (32.9%) to 125 (57.1%), while patients with normal US (n = 66/119) could be recategorized as BILAG-2004 Grade D (inactive disease).

Conclusions
Proposed changes to the definitions of inflammatory arthritis in the BILAG-2004 index will result in more accurate classification of patients who are more or less likely to respond to treatment.
Radiation protection for well logging operations in Saudi Arabia
Authors: Al-Somali Omar , Amer Mustafa 
Published: May 2023

Abstract
In well logging, sophisticated tools are inserted into a borehole to measure physical and geological properties of rocks surrounding the well. Some of these, known as nuclear logging tools, contain radioactive sources and are used to obtain useful information. When logging tools containing radioactive sources are inserted into the well, there is a risk that they may get stuck. If this occurs, a recovery operation, known as fishing, is used to attempt retrieval. If fishing fails to recover the radioactive sources, they are abandoned following an established protocol, which is in accordance with international, national and corporate standards, in addition to industry best practices. This paper provides an overview of radiation protection requirements for well logging operations in Saudi Arabia, to ensure the safety and security of radioactive sources, and the protection of workers and the public without impacting operational productivity.
Russian beneficiaries: challenges in relation to foundations in 2022 and prospects for Russian Private Foundations
Authors: Alimirzoev Sergei , Aleshchev Ilya 
Published: May 2023

Abstract
The lifetime (inter vivos) private foundation is a second attempt by the Russian legislator to introduce private foundations. The first (and practically stillborn) attempt was the post-mortem foundation of 2016, of which exactly one has been established. In stark contrast, there are already six lifetime private foundations, although their legal framework only came into force a year ago, and in a rather turbulent year at that. In this article, which follows on from the article in the 2022 issue, the authors review the main features and weaknesses of this new vehicle, examine its suitability for wealth management and succession planning, and attempt to predict its future popularity.
Patient satisfaction in anesthesiology: a narrative review
Authors: Bello Corina , Nübling Matthias , Luedi Markus M. , Heidegger Thomas 
Published: May 2023

Purpose of review
Healthcare is increasingly expanding its view in outcome discussions to integrate patient-reported outcomes such as patient satisfaction. Involving patients in the evaluation of services and the development of quality improvement strategies is paramount, especially in the service-oriented discipline of anaesthesiology.

Recent findings
Currently, while the development of validated patient satisfaction questionnaires is well established, the use of rigorously tested scores in research and clinical practice is not standardized. Furthermore, most questionnaires are validated for specific settings, which limits our ability to draw relevant conclusions from them, especially considering the rapidly expanding scope of anaesthesia as a discipline and the addition of same-day surgery.

Summary
For this manuscript, we review recent literature regarding patient satisfaction in the inpatient and ambulatory anaesthesia setting. We discuss ongoing controversies and briefly digress to consider management and leadership science regarding ‘customer satisfaction’.
The Vestibular Time Constant and Clinical Response to Antimotion Sickness Medication
Authors: Lagami Daniel , Shupak Avi , Jamison Anna , Tal Dror 
Published: May 2023

Objective:
The therapeutic effects of antimotion sickness medications involve suppression of several components along the vestibular system. Scopolamine-based medications have proved to be the most effective anti-seasickness agents. However, there is high variability in individual responses. The vestibular nuclei, in which the vestibular time constant is modulated, contain acetylcholine receptors which are affected by scopolamine. The hypothesis of the study was that successful seasickness prevention by scopolamine requires vestibular suppression to be reflected by the shortening of the vestibular time constant.

Design:
Subjects were 30 naval crew members suffering from severe seasickness and were treated with oral scopolamine. The study participants were defined as responsive or non-responsive to the anti-seasickness medication according to the clinical outcome: successful response to scopolamine was defined as a reduction of seasickness severity from the highest score of 7 according to the Wiker scale to 4 or less. Scopolamine and placebo were assigned to each subject in a crossover, double-blind design. The horizontal semicircular canal time constant was evaluated by a computerized rotatory chair before, 1 and 2 hours after drug or placebo administration.

Results:
The vestibular time constant was significantly shortened from 16.01 ± 3.43 seconds to 12.55 ± 2.40 seconds (p < 0.001) in the scopolamine-responsive group but not in the nonresponsive group. In contrast, vestibular time constant values were 13.73 ± 4.08 and 12.89 ± 4.48 for baseline and 2 hours measurements, respectively. This change was not statistically significant.

Conclusions:
Reduction in the vestibular time constant after scopolamine administration can be used to predict whether motion sickness alleviation will occur. This will enable the administration of appropriate pharmaceutical treatment without the need for prior exposure to sea conditions.
High Long-Term Drug-Free Remission Rate for Acute Vogt–Koyanagi–Harada Disease with Appropriate Immunosuppressive Regimen
Authors: Wang Kaixuan , Zheng Chuanzhen , Zhao Guixia , Zhang Mi , Liu Tong , Li Huan , Tao Qingqin , Cheng Zhaohui , Li Xiaorong , Zhang Xiaomin 
Published: May 2023

Abstract

Purpose:
To report the clinical profile and outcomes of acute Vogt–Koyanagi–Harada (VKH) disease with a strict immunosuppression regimen and investigate the risk factors for a prolonged disease course.

Methods:
A total of 101 patients with acute VKH (202 eyes) with more than 24 months of follow-up were recruited from January 2011 to June 2020. They were divided into two groups according to the interval between the onset of VKH and treatment. Oral prednisone was gradually tapered off by a diminished dose according to a relatively strict protocol. Patient responses to the treatment regimen were classified as long-term drug-free remission or chronic recurrent.

Results:
Ninety-six patients (95.0%) achieved long-term drug-free remission without recurrence, while 5 (5.0%) had chronic recurrence. Most patients achieved good best-corrected visual acuity (90.6%≧20/25). A generalized estimation equation model demonstrated that time of visit, ocular complications, and cigarette smoking were independent risk factors for a longer disease course, and smokers required a higher drug dose and longer treatment course than non-smokers.

Conclusions:
An immunosuppressive regimen with an appropriate tapering speed can lead to long-term drug-free remission in patients with acute VKH. Cigarette smoking significantly affects ocular inflammation.
MACULAR NEOVASCULARIZATION IN A CASE OF LATE-ONSET RETINAL DEGENERATION TREATED WITH AFLIBERCEPT
Authors: Ganesh Durga , Corradetti Giulia , Sadda Srinivas R. 
Published: May 2023

Purpose:
To describe the outcomes from treatment of macular neovascularization in an eye affected by late-onset retinal degeneration.

Methods:
A 72-year-old female patient presented with a history of decreased vision since several years. The patient was previously diagnosed with age-related macular degeneration and treated with anti–vascular endothelial growth factors.

Results:
Clinical examination of the retina and ultra-widefield color fundus photographs showed extensive atrophy in both eyes. The left eye showed macular neovascularization on fluorescein angiography, subretinal fluid on optical coherence tomography, and correspondent hemorrhages on the color fundus photography. Aflibercept anti–vascular endothelial factor treatment was used to treat the macular neovascularization in the left eye.

Conclusion:
We report a case of genetically confirmed late-onset retinal degeneration (heterozygous pathogenic mutation p.Ser163Arg in one C1QTN5 allele) with advanced degeneration of the retina complicated by macular neovascularization, which responded well to treatment with a single aflibercept injection.
Family Role in Care of Patients With Neurological Conditions: International Neuroscience Nursing Research Symposium Proceedings
Authors: von Gaudecker Jane , Andrade Christina , Baby Priya , Cassier-Woidasky Anne-Kathrin , Cubria Thanh , Hupperich Lena-Marie , Mariano Maria Elena M. , Mastamet Gladys , Nydahl Peter , Olson DaiWai M. , Sila Faith , Ramazanu Sheena , Strayer Andrea , Hirosue Miyuki , Rhudy Lori 
Published: May 2023

ABSTRACT

BACKGROUND: Discussions during the 2022 International Neuroscience Nursing Research Symposium highlighted the impact of family in the care of neuroscience patients. This sparked conversations about the need for understanding global differences in family involvement in the care of patients with neurological conditions. METHODS: Neuroscience nurses from Germany, India, Japan, Kenya, Singapore, Saudi Arabia, the United States, and Vietnam collaborated to provide a short summary of family involvement in caring for patients with neurological conditions in their respective countries. RESULTS: Family roles for neuroscience patients vary across the globe. Caring for neuroscience patients can be challenging. Family involvement in treatment decisions and patient care can be affected by sociocultural beliefs and practices, economic factors, hospital policies, manifestation of the disease, and long-term care requirements. CONCLUSION: Understanding the geographic, cultural, and sociopolitical implications of family involvement in care is of benefit to neuroscience nurses.
Extension of resection after positive intraoperative pathology during surgery for gastric and gastroesophageal junction adenocarcinoma – a retrospective cohort study
Authors: Plum Patrick S. , Barutcu Atakan G. , Pamuk Aylin , Mallmann Christoph , Chon Seung-Hun , Chiapponi Costanza , Dübbers Martin , Hellmich Martin , Moenig Stefan P. , Quaas Alexander , Hoelscher Arnulf H. , Bruns Christiane J. , Alakus Hakan 
Published: May 2023

Background:
Residual tumor at the resection margins after surgery for gastric and gastroesophageal junction (GEJ) adenocarcinoma is a known prognostic factor. In this single-center, retrospective cohort study in a tertiary referral center, we aimed to evaluate the relevance of intraoperative pathology consultation (IOC) and consecutive extension of surgery on patient survival.

Study design:
Of 737 consecutive patients undergoing (sub)total gastrectomy for gastric or GEJ adenocarcinoma, 679 cases with curative intent surgery between 05/1996 and 03/2019 were included. Patients were categorized into: i) R0 without further resection (direct R0), ii) R0 after positive IOC and extension of resection (converted R0) and iii) R1.

Results:
IOC was performed in 242 (35.6%) patients, in 216 (89.3%) at the proximal resection margin. Direct R0 status was achieved in 598 (88.1%), converted R0 in 26 (3.8%) of 38 (5.6%) patients with positive IOC and R1 in 55 (8.1%) patients. Median follow-up was 29 months for surviving patients. 3-year survival rate (3-YSR) was significantly higher for direct R0 compared to converted R0 with 62.3% compared to 21.8% (hazard ratio (HR)=0.298; 95%CI=0.186-0.477, P<0.001). 3-YSR was similar between converted R0 and R1 (21.8% vs. 13.3%; HR=0.928; 95%CI=0.526-1.636, P=0.792). In multivariate analysis, advanced T (P<0.001), N (P<0.001), R (P=0.003) and M1 status (P<0.001) were associated with worse overall survival (OS).

Conclusion:
IOC and consecutive extended resection for positive resection margins in gastrectomy for proximal gastric and gastroesophageal junction does not achieve long-term survival benefits in advanced tumor stages.
Prognostic value of Toll-like receptor 4 on human monocyte subsets combined with computed tomography-adapted Leaman score assessing coronary artery disease
Authors: Ozaki Yuichi , Kashiwagi Manabu , Imanishi Toshio , Katayama Yosuke , Taruya Akira , Nishiguchi Tsuyoshi , Shiono Yasutsugu , Kuroi Akio , Yamano Takashi , Tanimoto Takashi , Kitabata Hironori , Tanaka Atsushi 
Published: May 2023

Background
Upregulation of Toll-like receptor 4 (TLR-4) is associated with coronary plaque vulnerability assessed by coronary computed tomography angiography (CCTA). Computed tomography-adapted Leaman score (CT-LeSc) is an independent long-term predictor of cardiac events. The relationship between the TLR-4 expression of CD14++CD16+ monocytes and future cardiac events is unknown. We investigated this relationship using CT-LeSc in patients with coronary artery disease (CAD).

Methods
We analyzed 61 patients with CAD who underwent CCTA. Three monocyte subsets (CD14++CD16−, CD14++CD16+, and CD14+CD16+) and the expression of TLR-4 were measured by flow cytometry. We divided the patients into two groups according to the best cutoff value of the TLR-4 expression on CD14+CD16+ which could predict future cardiac events.

Results
CT-LeSc was significantly greater in the high TLR-4 group than the low TLR-4 group [9.61 (6.70–13.67) vs. 6.34 (4.27–9.09), P < 0.01]. The expression of TLR-4 on CD14++CD16+ monocytes was significantly correlated with CT-LeSc (R
2 = 0.13, P < 0.01). The expression of TLR-4 on CD14++CD16+ monocytes was significantly higher in patients who had future cardiac events than in those who did not [6.8 (4.5–9.1) % vs. 4.2 (2.4–7.6) %, P = 0.04]. High TLR-4 expression on CD14++CD16+ monocytes was an independent predictor for future cardiac events (P = 0.01).

Conclusion
An increase in the TLR-4 expression on CD14++CD16+ monocytes is related to the development of future cardiac events.
Orthopaedic Trauma Association Global Outreach Task Force Proceedings
Authors: Benson Emily 
Published: May 2023

Abstract

Introduction:
In 2020, the Orthopaedic Trauma Association (OTA) adopted an updated strategic plan emphasizing global outreach. A task force was appointed to better understand the current global orthopaedic trauma educational demand and how the organization may better partner with our global colleagues. This article provides a description of the process and the results of the findings.

Methods:
First, the current international demographics of the OTA membership were reviewed. Then, 2 surveys were distributed. The first was sent to all current members of the OTA to determine how important the members believe that global orthopaedics should be to the organization's mission. The second survey was sent out to our international orthopaedic trauma colleagues. The results of both surveys were reviewed, analyzed, and summarized in an executive summary report which was presented to the OTA Board of Directors earlier this year.

Results:
The responses from the membership survey indicated a keen interest in the development of global outreach within our organization. The global outreach survey received 72 responses from 28 different countries, mostly lower and lower-middle income countries. This included many countries in Asia and Africa who had no prior relationship with the OTA. Most respondents were already using online educational materials and expressed a desire for more high-quality online offerings as well as regional resource-specific orthopaedic trauma courses.

Conclusion:
The overwhelming majority of member respondents believe that global orthopaedics is highly important and central to our mission. Similarly, a majority of the international respondents believed that global orthopaedics is necessary and worthwhile. They expressed a need for more educational opportunities and collaboration, particularly in the areas of online offerings as well as regional, resource-specific courses.
The first complete mitochondrial genome ofSphaeniscus atilius(Walker, 1849) (Diptera: Tephritidae) and implications for the phylogenetic relationships of Tephritidae
Authors: Guo Shibao , Chen Junhua , Song Nan , Zhang Fangmei 
Published: May 2023

AbstractThe nearly complete mitochondrial genome ofSphaeniscus atiliuswas characterized and annotated in this study. The mitogenome was 16,854 bp in length and encoded 37 typical mitochondrial genes, including 13 protein-coding genes, 22 tRNA genes, 2 ribosomal RNA genes, and a control region. The total length of the 13 PCGs was 11,140 bp, and the AT content was 79.8%. There were five types of start codons, ATT (nad2,nad3,nad5, andnad6), ATG (cox2,cox3,atp6, nad4,nad4l, andcob), CGA (cox1), as well as ATC (atp8) and ATA (nad1). Most of the PCGs had typical TAA stop codons, exceptnad5which terminated with incomplete forms T-. Ile, Phe, Leu and Asn were the most frequently used amino acids in mitochondrial PCGs. Most tRNA genes could be folded into the typical cloverleaf structure, excepttrnS1andtrnTwhich lacked the dihydrouridine (DHU) and TΨC arms, respectively. Phylogenetic analyses based on 13 protein-coding genes among the available sequenced species of family Tephritidae by maximum likelihood methods suggested the genus relationship of Tephritidae: ((Bactrocera,Dacus,Zeugodacus),Felderimyia,Anastrepha), (Acrotaeniostola, (Neoceratitis,Ceratitis),Euleia,Rivellia), (Procecidochares, (Tephritis,Sphaenisscus))))). Our results presented the first mitogenome fromSphaeniscusand offer insights into the identification, taxonomy, and phylogeny ofSphaeniscus atilius.
Effect and correlation of intraocular pressure on the refractive status of children and adolescents
Authors: Yingying Nie , xiaoxiao Wu , xunlang Zhang , Chih-Huang Yang , yufeng Song , Junguo Duan 
Published: May 2023

AbstractObjectiveTo explore the effect of IOP on the refractive error in children and adolescents, and to analyze the correlation among IOP, AL and diopter of refraction.MethodsConducting a cross-sectional study. A total of 3256 students (6511 pairs of eyes) aged between 4 and 15 in Jinniu district who presented for ocular health examination during October 2018 and October 2021 were selected, including 1735 boys (3470 eyes) and 1521 girls (3041 eyes).The differences between groups were analyzed by analysis of variance, correlation analysis by Pearson, data were analyzed by statistical software SPSS 25.0.ResultsThere were significant differences in SE, IOP and AL between each group (P < 0.001), whereas IOP, AL were positively correlated with SE, respectively. The average IOP of female (17.45 ±2.56mmg) was higher than that of male (17.08 ±2.60mmg), while the mean AL of male (23.46 ±0.81 mm) was longer than that of female (22.91 ±0.83 mm). There was weak or no correlation between IOP and AL (r = 0.126, P < 0.001). No correlation was found between IOP and SE (r = 0.116, P < 0.001). Positive correlation between AL and SE (r = 0.632, P < 0.001) was noted.ConclusionThe increase of myopia degree in children at different ages is manifested by the increase of intraocular pressure and axial length, the increase of axial length is one of the main reasons affecting diopter.However, IOP may not directly lead to increase of myopia in children and adolescents within the range of normal IOP.SynopsisThis study suggests that there is no direct relationship between axial length and refraction or intraocular pressure, and intraocular pressure may not be a direct factor influencing the development of myopia.