bluuebunny/crossref_metadata_2025_split huggingface dataset:
Possible Association between Toxoplasma gondii Infection and Sleep
Disorders: A Systematic Review
Authors: Nayeri Tooran , Sarvi Shahabeddin , Daryani Ahmad 
Published: July 2023

Background:
Few studies investigated the relationship between toxoplasmosis and sleep
disorders. Sleep disorders can lead to suicidal behavior and traffic accidents. Therefore, the purpose of
this study is to collect information and investigate the possible relationship between Toxoplasma
gondii (T. gondii) and sleep disorders.

Methods:
To achieve the goal of the present study, five English databases (PubMed, ScienceDirect,
Web of Science, Scopus, and ProQuest) were systematically searched for related studies from their
inception until October 18, 2022. The obtained articles were screened based on the title, abstract, and
full text. Then, the quality of the papers investigating the relationship between toxoplasmosis and sleep
disorders was evaluated, and finally, the data from the relevant studies were extracted in a Microsoft
Excel data sheet.

Results:
Eight articles (4 case-control and 4 cross-sectional studies) were entered in this systematic
review containing 926 patients with sleep disorders and 1877 people without sleep disorders in casecontrol
studies, out of which 212 (22.89%) and 392 (20.88%) individuals were positive for anti-T.
gondii IgG antibody using different serological methods. Also, 2885 people with sleep disorders were
investigated for anti-T. gondii IgG antibody in cross-sectional studies, out of which 1559 (54.03%)
cases were positive.

Conclusion:
The results of this study suggest that T. gondii infection may be a risk factor for sleep
disorders. However, the number of related studies is small, and there are contradictions in the findings
of these articles. Therefore, further studies are necessary to clarify the possible association between T.
gondii infections and sleep disorders.
Ethnopharmacological Uses, Pharmacological Activities, and Therapeutic Applications of Tectochrysin in Medicine: An Important Class of Dietary Flavonoid
Authors: Patel Dinesh Kumar 
Published: July 2023

Background:Natural products and their derived pure phytochemicals have enormous potential to treat human disorders and associated secondary complications. Natural products are widely consumed by humans due to their rich phytochemical content, diverse therapeutic potential and cost-effectiveness compared to allopathic medicine. Flavonoids are a well-known class of polyphenolic compounds widely present in the plant kingdom. Tectochrysin is an important class of dietary flavonoids present in foods and fruits. Tectochrysin has anti-tumor, anti-Alzheimer’s, and antimicrobial activities in medicine. Pharmacological studies have signified the biological application of tectochrysin in health sectors for the treatment of hepatic and gastrointestinal complications.Methods:This current review summarizes the updated scientific information on the medicinal importance and pharmacological activities of tectochrysin. Scientific information on tectochrysin was collected from PubMed, Science Direct, Google Scholar, and Google with some additional resources, including books, dissertations, and scientific reports in the present work. Collected scientific information was further categorized into medicinal uses, pharmacological activities, and analytical aspects in the present paper. Furthermore, detailed pharmacological activities of tectochrysin were discussed in the present work, with analytical aspects used for the separation, isolation and identification of tectochrysin in order to explore its therapeutic potential in medicine.Results:Phytochemical analysis of propolis, Alpinia oxyphylla and Lychnophora markgravii led to the isolation of tectochrysin. This present work signified the anticancer activity of tectochrysin on prostate cancer, human colon cancer, and breast cancer. Moreover, its anti-osteoporosis, antiinflammatory, anti-oxidant, anti-microbial, anti-diarrheal, and hepatoprotective activity were also discussed in the present work. Further effectiveness of tectochrysin in Alzheimer's disease, SARSCoV- 2, nitric oxide production, aryl hydrocarbon receptor, and age-related diseases was further explored in the present work. It has been found that experimental animal data also supports its antimicrobial, anti-oxidant, and metabolic functions. Analytical data indicated its separation, isolation, and identification in different samples.Conclusion:Scientific data presented in this review signifies the biological importance and therapeutic potential of tectochrysin in medicine.
A Comprehensive Review on Niosomes as a Tool for Advanced Drug
Delivery
Authors: Sharma Shivani , Garg Akash , Agrawal Rutvi , Chopra Himansu , Pathak Devender 
Published: July 2023

Abstract:
Over the past few decades, advancements in nanocarrier-based therapeutic delivery have
been significant, and niosomes research has recently received much interest. The self-assembled
nonionic surfactant vesicles lead to the production of niosomes. The most recent nanocarriers, niosomes,
are self-assembled vesicles made of nonionic surfactants with or without the proper quantities of
cholesterol or other amphiphilic molecules. Because of their durability, low cost of components, largescale
production, simple maintenance, and high entrapment efficiency, niosomes are being used more
frequently. Additionally, they enhance pharmacokinetics, reduce toxicity, enhance the solubility of
poorly water-soluble compounds, & increase bioavailability. One of the most crucial features of niosomes
is their controlled release and targeted diffusion, which is utilized for treating cancer, infectious
diseases, and other problems. In this review article, we have covered all the fundamental information
about niosomes, including preparation techniques, niosomes types, factors influencing their formation,
niosomes evaluation, applications, and administration routes, along with recent developments.
Assessing the Efficacy of Berberine Hydrochloride-loaded Transethosomal
Gel System in Treating Dermatophytosis Caused by Trichophyton rubrum
in ex-vivo, in-vitro and in-vivo Models
Authors: Mishra Koushlesh Kumar , Kaur Chanchal Deep , Singh Sunil , Tiwari Abhishek , Tiwari Varsha , Sharma Ajay 
Published: July 2023

Background:
Dermatophytosis is the most common dermatological disorder worldwide.
Many drugs are available in the market for the treatment of dermatophytosis, but they have
had limited success due to the stratum corneum barrier, antifungal resistance, drug permeation,
drug retention in skin layers, etc. Thus, there is a constant need for new topical compounds that
are effective against dermatophytosis. Berberine-hydrochloride is an attractive candidate to become
an antifungal drug, and by using nanotechnology, it achieves deeper penetration in skin layers
with enhanced permeability through the stratum corneum.

Methods:
In this study, we developed an oleic acid-containing berberine-hydrochloride-loaded
transethosomal gel for effective treatment of dermatophytosis by Trichophyton rubrum. Berberine-
hydrochloride-loaded transethosomal gels were fabricated using the hot homogenization
method, followed by the incorporation of transethosomes into the gel-based system using carbopol
934. Transethosomal gel was characterized by physicochemical properties, in vitro drug release,
ex-vivo permeation studies, CLSM visualization, antifungal activity, histopathological evaluation,
and dermatokinetic study.

Results:
Berberine-hydrochloride-loaded transethosomes seemed to be spherical and found in a
range between 200-300 nm. Berberine-hydrochloride-loaded transethosomal gel formulation also
exhibited controlled ex-vivo permeation of berberine-hydrochloride over 24 hr through excised rat
skin, and CLSM confirmed deeper penetration into skin layers. The in vivo study revealed that
transethosomal gel had a healing effect on the skin of Wistar rats infected with Trichophyton
rubrum and was better than luliconazole cream. The histopathological evaluation confirmed its
safety, and the dermatokinetic study showed transethosomal gel superiority over marketed cream.

Conclusion:
Therefore, the incorporation of berberine hydrochloride-loaded transethosomal
nanosystems into the gel has the potential to enhance antifungal activity and permeation through
transdermal drug delivery.
Analisis nilai-nilai karakter dalam Tut Wuri Handayani sebagai asas pendidikan nasional
Authors: Sugiyanto Sugiyanto , Yusuf-LN Syamsu , Supriatna Mamat , Budiamin Amin 
Published: July 2023

Penelitian ini bertujuan mengkaji nilai-nilai karakter yang terkandung dalam Tut Wuri Handayani. Tut wuri handayani merupakan suatu asas dan landasan pendidikan yang mengandung makna bahwa sebagai pendidik harus memfasilitasi setiap anak (peserta didik) untuk mencapai tingkat perkembangan yang utuh dan optimal. Pendekatan penelitian ini yaitu pendekatan fenomenologi. Metode penelitian ini menggunakan metode hermeneutika fenomenologi yang diarahkan pada pengalaman hidup dan untuk menafsirkan “teks” kehidupan. Teknik pengumpulan data melalui library research dan wawancara. Sumber data dalam penelitian terdiri dari tulisan pemikiran Ki Hadjar Dewantara tentang tut wuri handayani dan wawancara tokoh Tamansiswa. Analisis data menggunakan Interpretative Phenomenological Analysis (IPA). Hasil penelitian menunjukkan bahwa semboyan tut wuri handayani terdapat nilai-nilai karakter yang dapat dikembangkan pada aspek tut wuri handayani, ing madya mangun karsa, dan ing ngarsa sung tuladha sebagai landasan pendidik dalam teori dan praksis Pendidikan. Semboyan Tut wuri handayani tepat diterapkan dalam sistem pendidikan nasional, yang mampu merangsang anak (peserta didik) melakukan belajar secara merdeka dengan menghindarkan perilaku yang tidak sesuai dengan aturan dan norma. Kata kunci : tut wuri handayani, nilai-nilai karakter, pendidikan
Comparative Study of Quantitative Real-Time Monitoring QRT-PCR for BCR-ABL Gene in Chronic Myelogenous Leukemia (CML) Between Blood and Bone Marrow Samples
Authors: Haleem Azhar , Al-Ani Rana , Burhan Ghada 
Published: July 2023

Objectives: This study aimed to assess the quantitative real-time RT-PCR (QRT-PCR) technique as a diagnostic tool for molecular surveillance of the BCR-ABL duplicate in Chronic Myelogenous Leukemia (CML) using both peripheral blood (PB) and bone marrow (BM) samples.
Methods: Prospective analysis has been conducted a by quantitative real-time RT-PCR (QRT-PCR) for both PB and BM specimens, from 25 patients with untreated CML. QRT-PCR investigation was carried out previous and during treatment with Imatinib for untreated CML. Statistical examinations showed useful agreement of PB and BM pre- treatment specimens. Nevertheless, using the SPSS statistical method that estimates the agreement between PB and BM data,
Results: This study showed low correspond of BCR-ABL measurements in PB and BM for specimens acquired through treatment. PB values tended to be lower than the conformable BM values [average difference = -0.37 (p<0.001) in 36 coupled samples] and the 95% limits of agreement ranged from -1.23 to 0.48. Nevertheless, the present study showed that BM and PB QRT-PCR values followed a similar direction during treatment (Spearman correlation coefficient, 0.83; 95% CI, 0.70, 0.96).
Conclusion: Our findings imply that PB and BM measures of BCR-ABL are frequently quantitatively different. The most accurate way to determine whether there is minimal residual disease is through BM sampling because BM results tend to be greater than PB values (MRD). Based on these findings, we advise avoiding switching BM and PB sampling for MRD monitoring during CML treatment because doing so could result in incorrect interpretation of treatment outcomes.
Pengaruh Penggunaan Metode Qiroah Terhadap Prestasi Belajar Siswa Dalam Pelajaran Bahasa Arab di MDT Al-Qona’ah Kabupaten Bandung
Authors: Asrofi Imam , Taryana Acep 
Published: July 2023

Bahasa merupakan bahasa yang sangat penting, tanpa kita sadari bahasa Arab termasuk bahasa yang digunakan setiap hari dalam praktek ibadah seperti ketika shalat dan berdoa. Bagi siswa di Indonesia yang mempunyai latar belakang kemahiran membaca tulisan latin, kemahiran membaca tulisan Arab merupakan suatu masalah, sebab alphabet Arab berlainan dengan alphabet latin. Metode qiroah adalah metode yang dilakukan dengan menyajikan materi pembelajaran dengan mengutamakan membaca, baik dengan menggunakan suara maupun di dalam hati. Dengan metode qiroah siswa diharapkan mampu berbahasa Arab dengan fasih, benar dan lancar sesuai kaidah-kaidah. Tujuan penelitian ini untuk mengetahui penerapan metode qiroah dan pengaruh metode qiroah terhadap hasilprestasi belajar siswa pada mata pelajaran bahasa arab. Penelitian ini menggunakan pendekatan kuantitafif dengan metode experimen. Teknik pengumpulan data dengan observasi, tes dan dokumentasi dengan sampel yang diambil adalah kelas IV sebanyak 36 siswa. Hasil penelitian menyatakan bahwa ada pengaruh metode qiroah terhadap prestasi belajar siswa ditunjukkan dengan adanya peningkatan nilai dari pre-test dan post-test. Perbedaan nilai pre-test dengan hasil rata-rata 70,5 meningkat menjadi 78,5. Hasil uji hipotesis yang peneliti ajukan Ho ditolak dan Ha diterima ditunjukkan bahwa t hitung = 17,33 > t tabel = 1,687.
ANALISIS FENOMENA CHILDFREE MENURUT PERSPEKTIF IMAM AL-GHAZALI
Authors: Persada Bahtera , Dinnar Malik , Ardiansyah Rio , Fasyaya Qiyan 
Published: July 2023

An ideal family consist of father, mother and child. This concept was deeply embedded society. Based on the stereotype, many married couples followed or made pregnancy programme soon after getting married, Howefer, times passed and development is inevitable. Nowadays, a family with child is not the only concept for marriage. Some couples started to have a childfree. It is a family without biological child. This phenomenon comes as polemic especially for moslems. As we know, in Islam a couple married is suggested to have children as descendants. Furthermore, having many children is considered as Sunnah to follow Rasulullah SAW. This research will be conducted using descriptive qualitative method viewed thought subjective approach by imam Al-Ghazali. Based on perspective of imam Al-Ghazali, childfree may be done in certain condition, for example to reduce mafsadat in marriage life in ‘azl way.
Hematology Reference Values in Indonesian Children
Authors: Timan Ina S. , Aryati Aryati 
Published: July 2023

Every clinical laboratory has to establish its reference ranges for every parameter analyzed. These reference values are intervals considered normal in a healthy person's physiological condition. It will be used by the clinician or other health professionals to interpret the laboratory test results of the patient for making diagnostic decisions, monitoring patient therapy, and predicting the prognosis and it is also used in epidemiology studies. A reference range is defined as an interval in which 95% of a reference population’s values fall. It is very crucial to establish reference intervals for the local population as it is sometimes affected by ethnicity, nutrition, food habits, and economic and other local conditions. Hematology is the most common test performed in a clinical laboratory, and the most used parameter by the clinician including pediatricians. There up to now no well-established reference interval for hematological parameters in pediatrics and children in Indonesia. The reference interval used for hematology parameters in Indonesia is based on reference intervals from other countries or the manufacturer of the hematology analyzers used in a particular laboratory. Establishing a population-specific hematology reference interval is very difficult for pediatrics and children, so it is rarely performed. This study aims to compile the results of hematology parameters from Indonesian children to establish an Indonesian reference value for hematology. The method used was compiling data for the hematology parameter intervals based on studies performed in the Indonesian population and presented as 95% confidence intervals. A pediatric reference range for several hematology parameters has been established based on 3 groups of age in Indonesian children.
The effect of obesity on cognitive function, anxiety and depression in pregnant patient during regional anesthesia
Authors: Chernykh O. A. , Lahin R. E. , Shchegolev A. V. 
Published: July 2023

Background. A number of studies have associated aggravation of cognitive impairment, anxiety and depression in pregnant women with anesthesia. In addition, obesity during pregnancy itself is associated with an increased risk of developing these complications.The objective was to study the effect of obesity on cognitive function, anxiety and depression in pregnant women during regional anesthesia.Materials and methods. The study included 70 pregnant women who were admitted for planned delivery. Patients were divided into two groups: obese pregnant women (BMI≥ 30) (n = 35) and pregnant women with normal weight (BMI < 30) (n = 35). All patients underwent surgery under spinal anesthesia. The indicators of cognitive function, anxiety, and depression were evaluated using specially selected tests before surgery and on the third day of the postoperative period.Results. The development of obesity during pregnancy was accompanied by an impairment of cognitive functions. After surgery, in the BMI≥ 30 group, cognitive function according to the MOS test decreased from 25.1 (25.9; 24.2) to 24.3 (25.2; 23.4) points (p = 0.004), and in the BMI < 30 group, there were no statistical differences – 26.3 (27.1; 25,5) and 25.6 (26.5; 24.7) points (p = 0.071). In addition, the baseline indicators of anxiety and depression in obese pregnant women were higher in comparison with pregnant women with normal weight (p < 0.001). Performing a cesarean section under spinal anesthesia in all patients led to a decrease in anxiety and an increase in depression in the BMI≥ 30 group from 7.2 (8.1; 6.7) to 6.9 (7.5; 6.3) points (p = 0.004), and in the BMI < 30 group – from 6.5 (6.8; 6.2) to 6.1 (6.5; 5.7) points (p = 0.038).Conclusion. The presence of obesity during pregnancy was revealed in combination with impairment of cognitive functions even before surgery, after delivery under spinal anesthesia, cognitive dysfunction increased.
The History of Human Communication: How Did Humans Build Language and Become World Leaders
Authors: Morissan Morissan 
Published: July 2023

The study of human communication history is currently very limited and even if there is, it is still limited to the discussion of the history of mass media such as newspapers, radio, and television, which began to appear at the end of the 19th century. There is no communication study that discusses how humans (Homo sapien) first, tens of thousands of years ago, communicated as humans. How did Sapiens create a language that distinguished him from animals? How did prehistoric humans use language to build group communication so that they became effective hunters and gatherers? This article aims to show how the sciences of history and biology have played a major role in building our understanding of the beginnings of human communication as a foundation for understanding communication itself. Research method used is the qualitative approach where it utilizes a review of the relevant academic publication to provide a comprehensive explanation of the raised questions. To conduct the review, an extensive and integrative search of articles published in major organizational academic research was performed. The integrative approach to systematic literature review used in this article differs from meta-analysis in that it does not utilize econometric and statistical procedures for data synthesis and analysis.The results show, based on previous studies, that Sapiens first communicated as humans when they were able to create abstract objects, which are things that simply don't exist in this world. Sapien is a leader over other animals because of this ability. Effective group communication builds on Sapien's pleasure in gossip. Ultimately, the ability to construct fiction and myth allowed Sapien to build organizations, nations, and even empires.
PEMBERDAYAAN MASYARAKAT DALAM PEMANFAATAN JERAMI PADI MENJADI KOMPOS
Authors: Kurniasanti Sandryas Alief , Holik Abdul 
Published: July 2023

Program Pemberdayaan Desa Tambong ini sangat mendukung program pemerintah daerah yaitu pemulihan perekonomian berbasis UMKM, pertanian, perikanan, dan pariwisata. Selain itu juga untuk mendorong peningkatan usaha pertanian dan perikanan, memberikan bantuan pupuk, bibit, pelatihan peningkatan kapasitas SDM petani, sektor lapang, hingga pengembangan start up usaha pertanian. Permasalahan yang dihadapi oleh mitra saat ini adalah menumpuknya limbah pertanian padi yang berupa jerami padi serta kurangnya kesadaran para petani tentang sistem pertanian organic. Pemanfaatan limbah jerami padi menjadi kompos guna meningkatkan pertumbuhan dan produksi padi khususnya pada kelompok tani Randu Agung Dusun Krajan Desa Tambong Kecamatan Kabat Kabupaten Banyuwangi. Teknis pelaksanaan program ini adalah dengan memberikan pelatihan teknis tentang cara pembuatan kompos jerami padi dan mendampingi implementasinya setelah berakhirnya program ini.
Kata kunci: Banyuwangi, Desa Tambong, jerami, kompos, padi
ABSTRACT
Empowerment program tambong village it will support regional government programs that is based umkm economic recovery, agriculture, fisheries, and tourism. In addition to advance the effort agriculture and fisheries, giving fertilizer, seeds, building training capacity building human resources farmers, airy sector, until the development of start up agricultural businesses. Problems counterparts now is the mounting rice agricultural waste of rice straw and the lack of awareness farmers about the system organic farming. Utilization of waste rice straw become compost to bolster growth and rice production in particular the farmers the hamlet randu krajan tambong village in Kabat Banyuwangi district. The technical implementation of this program is to technical training about how composting rice straw and accompanies their implementation after the end of this program.
Keywords: Banyuwangi, compost, rice straw, Tambong Village