bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spezifische Arbeitsbelastungen bei Mitarbeitenden mit
Migrationshintergrund in der Kranken- und Altenpflege: Ein systematisches
Review
Authors: Schmidt Sebastian , Lörzing Romina , Jahn Jennifer , Andersch-Rupprecht Claudia , Emmert Martin , Nagel Eckhard 
Published: December 2022

Zusammenfassung
Hintergrund Multimorbidität, zunehmend chronisch-erkrankte
Patient*innen sowie der demografische Wandel führen in
Deutschland zu einem erhöhten Versorgungsaufwand bei zunehmender
Personalknappheit in der Kranken- und Altenpflege. Vor dem Hintergrund des
bestehenden Fachkräftemangels in der Kranken- und Altenpflege werden
zunehmend Pflegende mit Migrationshintergrund der 1. und 2. Generation (PmMH)
rekrutiert und in bestehende (Unternehmens-) Kulturen integriert. Dies stellt
einen wichtigen Ansatzpunkt für eine dauerhafte und bedarfsgerechte
Versorgungslandschaft dar.
Ziel der Studie Ziel der Studie ist die Identifikation und Analyse von
spezifischen Belastungen von PmMH am Arbeitsplatz der Kranken- und
Altenpflege.
Material und Methoden Es wurde eine systematische Literaturrecherche in
relevanten Fachdatenbanken (Pubmed, PsychInfo, Web of Science, Cochrane)
durchgeführt, ergänzt durch eine erweiternde Schneeball- und
Handsuche. Im Anschluss erfolgte eine deskriptive Ergebnisdarstellung der
Studieninhalte, welche in einem darauffolgenden Schritt durch mehrere Personen
iterativ in thematische Kategorien zusammengeführt und konsolidiert
wurden.
Ergebnisse Es wurden 15 Publikationen als relevant identifiziert und in
die Analyse eingeschlossen. Es konnten spezifische, migrationsassoziierte
Belastungsfaktoren identifiziert werden. Insbesondere die Kategorien:
„Diskriminierung und Rassismus“, „Sprach- und
Kommunikationsprobleme“ sowie „Kulturelle Anpassung“
prägen die (Zusammen-) Arbeit in der Kranken- und Altenpflege und
führen zu zusätzlichen Belastungen bei den Mitarbeitenden sowie
den Patient*innen und bilden konkrete Handlungsfelder für
betriebliche Akteur*innen.
Diskussion Die vorliegende Übersichtsarbeit konnte spezifische
Belastungen von PmMH identifizieren und zusammenfassen. Es ist an dieser Stelle
davon auszugehen, dass diese nicht einseitig, ausschließlich auf PmMH
wirken, sondern dass vielmehr bilaterale Verflechtungen bestehen. Betriebliche
Konzepte scheinen die bestehenden Herausforderungen bisher nicht adäquat
lösen zu können, sodass wirksame, nachhaltige Ansätze zu
finden sind. Inwiefern die benannten spezifischen Belastungen
ausschließlich PmMH beeinflussen, bleibt in diesem Kontext
unberücksichtigt, sodass sich hieraus obligater Forschungsbedarf
ergibt.
Die Perspektive der Patienten auf die HNO-Heilkunde – eine deutschlandweite Befragung
Authors: Horn Josephine , Tostmann Ralf , Dobel Christian , Löhler Jan , Guntinas-Lichius Orlando 
Published: December 2022

Zusammenfassung
Hintergrund Patientenorientierung zur Entscheidungsfindung für die beste Behandlung, aber auch die Patientenbeteiligung an Forschungsprojekten wird mehr gefordert.
Methoden In einer multizentrischen prospektiven Querschnittstudie haben HNO-Patienten im Juni 2021 in 27 HNO-Praxen, 18 HNO-Kliniken und 14 Universitäts-HNO-Kliniken die Möglichkeit, einen Laien-gerechten Fragebogen mit Fragen zur Patientenorientierung, evidenzbasierten Medizin, Forschungsbedarf und Gesundheitskompetenz ausgefüllt.
Ergebnisse 2023 Patientenantworten (46% weiblich; 49% 46–75 Jahre alt; 40% in HNO-Praxis) wurden ausgewertet. Als HNO-Erkrankung war am häufigsten eine Sinnesstörung (16,8%) oder ein Tumor (12,7%) angegeben. Gemeinsam bei Therapieentscheidungen zu agieren, wurde als Entscheidungsprozess favorisiert (43,5%). Genügend Zeit für das Gespräch wurde als wichtigstes Element der Beziehung genannt (15,8%). Die meisten Teilnehmer fühlten sich über die Behandlungsschritte gut informiert (42,4%). Bei der elektronischen Suche wurden vor allem allgemeine Suchmaschinen verwendet (50,3%). Drei Viertel der Teilnehmer (73,7%) hatten noch nie an einer Studie teilgenommen. Etwa zwei Drittel (62,8%) konnten sich das auch für die Zukunft nicht vorstellen. Faktoren wie Geschlecht, Alter, Schulbildung oder Ort der Befragung waren mit anderem Antwortverhalten assoziiert.
Diskussion Der Wunsch nach Patientenorientierung ist auch bei HNO-Patienten hoch und von den HNO-Ärzten in Praxis und Klinik auch häufig umgesetzt. Insbesondere Patienten mit geringer Schulbildung sollten bei der Planung und Durchführung von Studien stärker eingebunden werden, um Partizipationsmöglichkeiten gemäß den Empfehlungen der Förderinstitutionen zu geben.
Facet Joint Involvement in Early MRI Positive Axial
Spondyloarthritis
Authors: Becker-Capeller Detlef , El-Nawab-Becker Soham , Hul Marcus , Weber Nermin , Kapsimalakou Smaragda , Baraliakos Xenofon 
Published: December 2022

Abstract
Background The disease course of non-radiographic axial spondyloarthritis
(nr-axSpA), usually detected by magnetic resonance imaging (MRI), is often
unclear at the time of diagnosis. We investigated which MRI findings in the
sacroiliac joints (SIJs) and lumbar spine including the facet joints can be
observed over a two-year period in patients with newly diagnosed active
inflammatory lesions in the SIJs fufilling the Assessment of SpondyloArthritis
International Society criteria (ASAS) for Axial Spondyloarthritis (axSpA).
Methods Patients (n=56, age<45 years, 30 female and 26
male, symptom duration 3–30 months) consecutively diagnosed with
unilateral or bilateral sacroiliitis through MRI during an 18-month period and
meeting the ASAS criteria for axial SpA were followed up for two years. Clinical
examination, laboratory tests and an MRI of the sacroiliac joints (SIJs), lumbar
spine and facet joints were performed at diagnosis (t0), after one year (t1) and
after two years (t2).
Results At t0, 31 patients (55%) with a bone marrow edema (BME) in
the SIJs already had detectable changes in the facet joints, including signs of
inflammation or degenerative changes. At t2, patients with facet joint
involvement in t0 not only had more significant changes in the SIJs but also
significantly more changes in the vertebral bodies, including BME, fat lesions
and vertebral body erosions than patients without changes in the facet joints at
t0. All vertebral changes described might be potential indicators of progression
to radiographic axSpA (r-axSpA). These MRI findings are seen more frequently
over a short period of time than previously thought.
Conclusions MRI progression in the SIJs over a two-year period is
associated with increasing damage to the facet joints and vertebral bodies.
Involvement of the facet joints in the early stages of the disease may indicate
increasing changes in the vertebral bodies and thus a less favourable course of
axSpA.
Empfehlungen für ein Kerncurriculum für
Masterstudiengänge der Versorgungsforschung
Authors: Ernstmann Nicole , Kuske Silke , Holmberg Christine , Wensing Michel , Reuschenbach Bernd , Büscher Andreas , Neugebauer Edmund , Karbach Ute , Bethge Matthias , Ansmann Lena , Pfaff Holger 
Published: December 2022

ZusammenfassungZiel der vorliegenden Arbeit war es, Empfehlungen für ein Kerncurriculum
für Masterstudiengänge der Versorgungsforschung zu erarbeiten.
Hierzu wurde im ersten Schritt eine standardisierte Online-Befragung von
Hochschullehrenden durchgeführt. Im zweiten Schritt wurden die
Modulhandbücher der existierenden Studiengänge in Bezug auf ihre
Lehr-Lerninhalte analysiert. Die Inhalte wurden im dritten Schritt
ergänzt durch eine Literaturrecherche. Im letzten Schritt wurden die
Empfehlungen innerhalb einer Expertenrunde final diskutiert. Die resultierenden
Empfehlungen umfassen 13 Themen zu fünf Leitfragen mit 26 Unterthemen.
Die Schwerpunktthemen stammen aus den Bereichen der Grundlagenwissenschaften im
Kontext der Versorgungsforschung, des Gesundheitssystems und der
Gesundheitspolitik, dem (empirischen) Versorgungsforschungsprozess und dem
Wissenstransfer. Die vorliegenden Empfehlungen dürfen als
Diskussionsgrundlage und Ausgangspunkt für Weiterentwicklungen
verstanden werden. Die Erarbeitung von Empfehlungen ist ein fortlaufender
Prozess und eine fortwährende Aufgabe der wissenschaftlichen
Gemeinschaft, da sich die Kernkompetenzen von Versorgungsforschenden
kontinuierlich neuen Forschungsgegenständen, neuen Forschungsmethoden
und sich verändernden Rahmenbedingungen anpassen müssen.
Does Kangaroo Care Have an Effect on Transition Time from Gavage
Feeding to Full Oral Feeding in Premature Babies?
Authors: Şimşek Didem Coşkun , Aydın Mustafa , Günay Ulviye 
Published: December 2022

Abstract
Objectives Kangaroo care is a safe and effective alternative method to
conventional neonatal care for newborn babies. The aim of this study was to
evaluate the effect of kangaroo care on the transition time to full oral feeding
in preterm infants fed by gavage.
Methods This is a randomized controlled trial. This study was conducted in
a level III neonatal intensive care unit of a university hospital in eastern
Turkey 50 premature babies with a birth weight of≥1000 g and a
gestational age of 27–36 weeks, and their mothers were included in the
study. The cases were randomly divided into two groups: kangaroo care, which
would be applied up to five days a week, and standard care. Records of cases
were kept regularly from their hospitalization until they reached full oral
feeding.
Results Premature babies in the kangaroo care group reached full oral
feeding at 29.20±8.06 days after birth, while babies in the standard
care group reached full oral feeding at 44.60±21.90 days. The transition
period from gavage feeding to reaching full oral feeding was 13.60±6.83
days in the kangaroo care group, and 22.10±7.38 days in the standard
care group. The difference was statistically significant (p=0.007).
Conclusion Kangaroo care is an effective method to reduce the transition
time from gavage feeding to full oral feeding for premature babies.
MPFL Reconstruction Combined with a Modified Elmslie–Trillat Procedure for Recurrent Patellofemoral Instability
Authors: Mitani Genya , Serigano Kenji , Takagaki Tomonori , Hamahashi Kosuke , Takizawa Daichi , Sogo Yasuyuki , Sato Masato , Watanabe Masahiko 
Published: December 2022

AbstractSeveral combined procedures have been reported for treating recurrent patellofemoral instability (RPI) with various types and severity of morphological abnormalities, but none have identified absolute threshold values as indications for surgery. We performed medial patellofemoral ligament (MPFL) reconstruction combined with a modified Elmslie–Trillat (ET) procedure on 24 knees (10 male and 11 female patients) to treat RPI with morphological abnormalities corresponding to elevated tibial tubercle–trochlear groove (TT–TG) distance, significant patella alta, and trochlear dysplasia. The inclusion criteria were RPI with morphological abnormalities corresponding to one or more of the following: sulcus angle > 160 degrees, trochlear dysplasia of Dejour classification C or D, Caton–Deschamps index > 1.5, lateral shift ratio > 50%, congruence angle > 15 degrees, or TT–TG distance > 20 mm, including habitual dislocation of the patella. Skeletally immature patients and those with congenital dislocation of the patella were excluded. The Kujala score, International Knee Documentation Committee subjective score, Knee Injury and Osteoarthritis Outcome score (KOOS), and each item of the KOOS improved significantly after surgery. Patellar apprehension sign was present preoperatively in all cases, but all disappeared postoperatively. No instance of postoperative redislocation was observed. On radiographic examination, the mean Q angle, tilting angle, lateral shift ratio, congruence angle, Caton–Deschamps index, Insall–Salvati index, and TT–TG distance improved significantly after surgery. There were no significant differences in sulcus angle after surgery. These results suggest MPFL reconstruction combined with a modified ET procedure provides satisfactory outcomes based on radiological and clinical evaluations for RPI with morphological abnormalities corresponding to elevated TT–TG distance, significant patella alta, and trochlear dysplasia.
Agreement between an Early-Onset Neonatal Sepsis Risk Calculator and the Colombian Clinical Practice Guideline in Three Tertiary-Care Centers in Bogotá, Colombia
Authors: Quintero-Carreño Laura Milena , Quintero-Palacios Mayra Alejandra , Palacios-Ariza María Alejandra , Morales-Vélez Ana María , Méndez-Vargas Lina María , Beltrán-Higuera Sandra , Martínez Leslie Ivonne , Prieto-Jure Reynaldo 
Published: December 2022

Objective Clinical practice guidelines (CPG) worldwide help steer the management of early-onset neonatal sepsis (EONS). These documents typically discourage the use of risk assessment tools. However, prior work has shown that the Kaiser Permanente calculator (Early-Onset Sepsis Calculator [EOScalc]) could be a useful tool in EONS risk assessment. This study aimed to determine the agreement between the recommendations of the Colombian EONS CPG and those of the EOSCalc tool in a cohort of newborns in Bogotá, Colombia.
Study Design Multicenter retrospective observational cohort study. We included newborns with a gestational age ≥ 34 weeks who were admitted to the neonatal care unit with a suspected diagnosis of EONS between 2017 and 2019. Agreement between the two tools was examined using Cohen's kappa under two scenarios (unequivocal and cautious).
Results Of the 23.490 live births, 470 (1.71%) were admitted to the neonatal care unit with a presumptive diagnosis of EONS. This diagnosis was confirmed in seven patients by means of blood cultures, with group B streptococcus the most common organism (57%; 95% confidence interval [CI]: 18.4–90.1). A single death occurred among the patients with confirmed EONS (lethality: 14.3%). The overall incidence of EONS was 0.298 per 1,000 live births. After splitting the recommendations into two scenarios regarding antibiotic use, unequivocal and cautious, the agreement between EOSCalc and the CPG was below 15% (6 and 14%, respectively).
Conclusion Recommendations from the Colombian EONS CPG show poor agreement with the EOSCalc, with the latter detecting all newborns with EONS. Although the use of EOSCalc is clinically and administratively advantageous, further prospective studies are warranted to determine the safety of its implementation.
Key Points
Less Invasive Surfactant Administration: A Viewpoint
Authors: Mani Srinivasan , Rawat Munmun 
Published: December 2022

The standard of care in treating respiratory distress syndrome in preterm infants is respiratory support with nasal continuous positive airway pressure or a combination of continuous positive airway pressure and exogenous surfactant replacement. Endotracheal intubation, the conventional method for surfactant administration, is an invasive procedure associated with procedural and mechanical ventilation complications. The INSURE (intubation, surfactant administration, and extubation soon after) technique is an accepted method aimed at reducing the short-term complications and long-term morbidities related to mechanical ventilation but does not eliminate risks associated with endotracheal intubation and mechanical ventilation. Alternative methods of surfactant delivery that can overcome the problems associated with the INSURE technique are surfactant through a laryngeal mask, surfactant through a thin intratracheal catheter, and aerosolized surfactant delivered using nebulizers. The three alternative methods of surfactant delivery studied in the last two decades have advantages and limitations. More than a dozen randomized controlled trials have aimed to study the benefits of the three alternative techniques of surfactant delivery compared with INSURE as the control arm, with promising results in terms of reduction in mortality, need for mechanical ventilation, and bronchopulmonary dysplasia. The need to find a less invasive surfactant administration technique is a clinically relevant problem. Before broader adoption in routine clinical practice, the most beneficial technique among the three alternative strategies should be identified. This review aims to summarize the current evidence for using the three alternative techniques of surfactant administration in neonates, compare the three techniques, highlight the knowledge gaps, and suggest future directions.
Key Points
Clinical Outcome Data of Children Treated with Cannabis-Based Medicinal Products for Treatment Resistant Epilepsy—Analysis from the UK Medical Cannabis Registry
Authors: Erridge Simon , Holvey Carl , Coomber Ross , Hoare Jonathan , Khan Shaheen , Platt Michael W. , Rucker James J. , Weatherall Mark W. , Beri Sushil , Sodergren Mikael H. 
Published: December 2022

AbstractBackground There is a paucity of high-quality evidence of the efficacy and safety of cannabis-based medicinal products in treatment of treatment-resistant epilepsy (TRE) in children.Methods A case series of children (<18 years old) with TRE from the UK Medical Cannabis Registry was analyzed. Primary outcomes were ≥50% reduction in seizure frequency, changes in the Impact of Pediatric Epilepsy Score (IPES), and incidence of adverse events.Results Thirty-five patients were included in the analysis. Patients were prescribed during their treatment with the following: CBD isolate oils (n = 19), CBD broad-spectrum oils (n = 17), and CBD/Δ9-THC combination therapy (n = 17). Twenty-three (65.7%) patients achieved a ≥50% reduction in seizure frequency. 94.1% (n = 16) of patients treated with CBD and Δ9-THC observed a ≥50% reduction in seizure frequency compared to 31.6% (n = 6) and 17.6% (n = 3) of patients treated with CBD isolates and broad-spectrum CBD products, respectively (p< 0.001). Twenty-six (74.3%) adverse events were reported by 16 patients (45.7%). The majority of these were mild (n = 12; 34.2%) and moderate (n = 10; 28.6%).Conclusion The results of this study demonstrate a positive signal of improved seizure frequency in children treated with Cannabis-based medicinal products (CBMPs) for TRE. Moreover, the results suggest that CBMPs are well-tolerated in the short term. The limitations mean causation cannot be determined in this open-label, case series.
Synthesis of Chiral Primary Amines via Enantioselective Reductive Amination: From Academia to Industry
Authors: Zhang Xumu , Yin Qin , Shi Yongjie , Rong Nianxin 
Published: December 2022

AbstractChiral primary amines widely exist in drugs and are exceptionally important subunits or synthons in the syntheses of chiral secondary and tertiary amines of medicinal interest. Metal-catalyzed enantioselective reductive amination (ERA) of ketones with ammonium salts or ammonia provides a direct method for their synthesis. Although very useful, progress in this field has been very slow and important advances have only been achieved in the last few years. Several major challenges exist in this reaction, including (1) the reversible formation of unstable NH-imine intermediates; (2) the strong coordination property of N-containing reagents toward metal species; and (3) the lack of efficient catalytic systems that enable high enantiocontrol. Generally, the efficiency and enantiocontrol of this reaction is dependent on the substrate type, for instance, the use of α-keto esters/amides or aryl alkyl ketones is well established and they have even been used in the industrial production of chiral amine drugs. However, highly enantioselective control in dialkyl ketones, cyclic ketones, and α-keto acids remains unsolved. Herein, the historical development of ERA reactions with ammonium salts or ammonia gas is summarized, and novel synthetic applications toward useful synthons or drugs are presented. In addition, the factors restricting the growth of this method are also discussed.1	Introduction2	Enantioselective Reductive Amination via Hydrogenation2.1	Enantioselective Reductive Amination of β-Keto Esters/Amides2.2	Enantioselective Reductive Amination of Simple Ketones2.3	Enantioselective Reductive Amination of α-Functionalized Ketones2.4	Enantioselective Reductive Amination/Cyclization Cascade Reactions2.5	Others3	Enantioselective Reductive Amination via Transfer Hydrogenation4	Synthetic Applications5	Conclusions and Outlook
Urgent Pneumonectomy as a Result of an Endoleak Type III—A Late Complication after Aortic Stent Implantation
Authors: Kirschbaum Andreas , Mahnken Andreas , Wallot Pascal , Mirow Nikolas 
Published: December 2022

AbstractWe report on an octogenarian, who was hospitalized with acute hemoptysis. Computed tomography angiography revealed a monstrously large thrombosed aortic aneurysm in the left thoracic cavity, completely displacing the lung. Eighteen years ago, the patient had suffered traumatic rupture of the descending aorta loco typico. Surgical exploration revealed a large calcified aneurysmal sac, which had perforated into the left lung. Pneumonectomy was performed, and hemoptysis did not reoccur.
Applications of Three-Dimensional Printing in the Management of Complex Aortic Diseases
Authors: Magagna Paolo , Xodo Andrea , Menegolo Mirko , Campana Carlo , Ghiotto Luciano , Salvador Loris , Grego Franco 
Published: December 2022

AbstractThe use of three-dimensional (3D) printing is gaining considerable success in many medical fields, including surgery; however, the spread of this innovation in cardiac and vascular surgery is still limited. This article reports our pilot experience with this technology, applied as an additional tool for 20 patients treated for complex vascular or cardiac surgical diseases. We have analyzed the feasibility of a “3D printing and aortic diseases project,” which helps to obtain a more complete approach to these conditions. 3D models have been used as a resource to improve preoperative planning and simulation, both for open and endovascular procedures; furthermore, real 3D aortic models were used to develop doctor–patients communication, allowing better knowledge and awareness of their disease and of the planned surgical procedure. A 3D printing project seems feasible and applicable as an adjunctive tool in the diagnostic–therapeutic path of complex aortic diseases, with the need for future studies to verify the results.
Interventional Closure of a Ruptured Sinus of Valsalva with a Konar-Multifunctional Device
Authors: Krasemann Thomas , Dalinghaus Michiel , van den Berg Gert , Rebel Bas 
Published: December 2022

AbstractA 14-year-old girl with trisomy 13 presented with signs of respiratory failure. This was caused by the rupture of a sinus of Valsalva aneurysm into the right atrium. A Konar Multifunctional Occluder was used for closure. This is the first report of this device for this indication.
Synthesis of the Three Most Expensive l-Hexose Thioglycosides from d-Glucose
Authors: Borbás Anikó , Herczeg Mihály , Demeter Fruzsina , Bényei Attila 
Published: December 2022

AbstractThe biologically important l-hexoses, which are less widespread than d-hexoses, cannot be obtained from natural sources or can only be extracted very costly. Due to the complexity of their synthesis, their commercially available derivatives (which are sold mostly in free form) are also very expensive, which is further exacerbated by the current rapid rise in prices. In the present work, starting from the cheapest d-hexose, d-glucose, using inexpensive and readily available chemicals, a reaction pathway was developed in which the three most expensive l-hexoses (l-idose, l-altrose, and l-talose) were successfully prepared in orthogonally protected thioglycoside form, ready for glycosylation. The l-ido and l-talo derivatives were synthesized by C-5 epimerization of the corresponding 5,6-unsaturated thioglycosides. From the l-ido derivatives, the orthogonally protected thioglycosides of l-altrose were then prepared by C-4 epimerization. Different approaches to the preparation of the key intermediates, 5,6-unsaturated thioglycoside derivatives, were systematically investigated in the presence of various protecting groups (ether and ester) and using commercially available reagents.