bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engaging Human Services and Behavioral Health Professionals in Youth-led, Adult-guided Social Action Initiatives
Authors: Hill Kelli , Parker Rosalind , Randolph Cunningham Suzanne , Ramsey Lauren 
Published: February 2023

Professional and community leaders in Washington, DC have expressed the need for more capacity building and increased resources to address health inequities in the city’s underserved African American communities. Inequities (“food deserts,” community decay, and limited youth opportunities) require equity-informed approaches. Disparities (disproportionate substance use/behavioral health disorders) also require system-level approaches. In response, the Wards 7 and 8 DC Prevention Center (DCPC), a community-based nonprofit, collaborated with residents, community partners, and academic institutions to provide trainings and certifications to its team and community stakeholders.
Initially, DCPC Staff were trained through evidence-informed approaches including Certified Prevention Specialist (CPS) and Photovoice. CPS training uses workshops and tools from the DC Department of Behavioral Health (DBH) to train staff/students to conduct assessments and build community partnerships. Photovoice provides a less intimidating process for vulnerable populations and professionals to collect data, identify social/environmental factors that impact health and well-being, share concerns, communicate with policymakers, and identify solutions to collectively address issues.
In turn, DCPC Staff trained youth and professionals to conduct Photovoice assessments to highlight the misuse of opioids and the negative effects on their communities. Stakeholders continue to request the assistance of CPSs; and community partners seek the trainings for themselves. Academic partners have a community-based resource for students/faculty to learn from and support equity-informed initiatives. This paper presents additional lessons learned/best practices in how to apply this multi-component approach as an effective strategy for preparing professionals and students to engage in social action in similar areas, despite high risks and glaring inequities.
The Anti-Racism Behavioral Inventory: A Validation Study
Authors: Pieterse Alex L. , Kirkinis Katherine , Paiko Lynsay , Miller Matthew 
Published: February 2023

The current study extends the initial creation and validation of the Anti-Racism Behavioral Inventory (ARBI; Pieterse, Utsey & Miller, 2016), a measure designed to assess anti-racism awareness and behavior among Whites Americans. Given that the original measure was developed with a sample of graduate students in counseling psychology, the current study extends validation to a sample of White individuals who identify as anti-racism activists (N=153). Findings support the original bifactor factor model of the Anti-Racism Behavioral inventory (one general anti-racism behavior factor and three domain-specific factors: individual advocacy, awareness of racism, and institutional advocacy). Additional evidence for validity was supported through negative associations with measures of the color-blind racial attitudes, as well as positive associations with scores on the White Privilege Awareness Inventory. Implications of the findings for training and future research are discussed.
El localisme en les polítiques contra el sensellarisme
Authors: Sales Campos Albert 
Published: February 2023

Les polítiques públiques que aborden el sensellarisme a les grans ciutat europees s’han centrat en atendre a les persones sense sostre oferint allotjament temporal i acompanyament social. Les actuacions de les administracions i de les entitats socials es dissenyen i gestionen des de l’àmbit local. Les perspectives assistencialista i localista són conseqüència de la construcció d’un objecte d’estudi i d’intervenció social, la persona sense llar, desvinculat dels factors d’exclusió social i residencial que afecten al conjunt de la població. Dades d’estudis recents realitzats a Barcelona mostren la gran permeabilitat entre les situacions d’exclusió residencial descrites per les categories ETHOS, l’increment de la mobilitat transnacional i metropolitana de les persones excloses de l’habitatge i les dinàmiques supramunicipals de les seves estratègies de supervivència. Aquestes dades conviden a superar el localisme en la definició de la problemàtica i generar una agenda de recerca orientada a la prevenció.
Multidisciplinary approaches to identifying and managing global airways disease: Expert recommendations based on qualitative discussions
Authors: Backer Vibeke , Cardell Lars Olaf , Lehtimäki Lauri , Toppila-Salmi Sanna , Bjermer Leif , Reitsma Sietze , Hellings Peter W. , Weinfeld Dan , Aanæs Kasper , Ulrik Charlotte Suppli , Braunstahl Gert-Jan , Aarli Bernt Bøgvald , Danielsen Arild , Kankaanranta Hannu , Steinsvåg Sverre , Bachert Claus 
Published: February 2023

BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) and asthma frequently co-exist and share pathologic features. Taking a “global” treatment approach benefits diagnosis and treatment of both, but care is often siloed by specialty: joined-up clinics are uncommon. Our objectives were to explore expert opinion to give practical suggestions to identify adults needing global airways care; enhance cross-specialty working; and widen knowledge to support diagnosis and management, integrate with existing care pathways, and supplement existing guidelines.MethodsSixteen practicing physicians from northern Europe were invited for their national and/or international standing in treating asthma and/or chronic rhinosinusitis. Appreciative Inquiry techniques were used to guide their discussions.ResultsKey themes arising were screening and referral, collaboration on management, awareness and education, and research. Provided are screening criteria and suggestions for specialist referrals, and pointers for physicians to optimize their knowledge of global airways disease. Collaborative working is underscored, and practical suggestions are given for multidisciplinary teamworking within global airways clinics. Research gaps are identified.ConclusionThis initiative provides practical suggestions for optimizing the care of adults with CRSwNP and asthma. Discussion of the role of allergy and drug exacerbations on these conditions, and care for patients with other global airways diseases were beyond scope; however, we expect some principles of our discussion will likely benefit patients with related conditions. The suggestions bridge asthma and CRSwNP management guidelines, envisioning interdisciplinary, global airway clinics relevant to various clinical settings. They highlight the value of joint screening for early recognition and referral of patients.
Annual patterns of stratification, mixing and ventilation in long, deep, seasonally ice-covered François lake, British Columbia, Canada
Authors: Vagle Svein , Carmack Eddy 
Published: February 2023

François Lake is a long, deep, seasonally ice-covered, dimictic lake set in an east-west orientation in mid-British Columbia. As a baseline we here present data from a full-depth temperature mooring deployed at the lake’s mid-point in 2004–2005 and one full-depth conductivity-temperature-depth cast. We use these temperature records to define lake stability, scales of motion and the annual cycle of thermal stratification, mixing and deep-water ventilation. Owing to its length (110 km) both the Wedderburn and Lake numbers—indices of thermocline tilt and mixing under wind forcing—transition through critical values during fall and spring seasons, suggesting thermocline outcropping and strong turbulent mixing within the thermocline at these times. Owing to its depth (240 m) the decreasing temperature of maximum density (TMD) with depth (thermobaric effect) adds complexity to overturn events. Owing to its seasonal ice cover (2–3 months per year) the critical period for effective fall ventilation occurs before ice formation and concurrent wind shielding, while that of spring ventilation lies between the dates that the ice cover melts and the lake surface water warms above 4°C. While the lake undergoes full depth ventilation in both fall and spring, we show that both progress in distinct dynamical stages. Fall ventilation is more efficient than that of spring, and the transition temperature and resulting bottom temperature from fall to winter stratification (positive to inverse) and winter to spring stratification (inverse to positive) lies close to the temperature of maximum density calculated for the maximum depth of free and forced convection (in this case, closer to 3.7°C).
Serotonin and the ventilatory effects of etonogestrel, a gonane progestin, in a murine model of congenital central hypoventilation syndrome
Authors: Casciato Alexis , Bianchi Lola , Reverdy Manon , Joubert Fanny , Delucenay-Clarke Roman , Parrot Sandrine , Ramanantsoa Nélina , Sizun Eléonore , Matrot Boris , Straus Christian , Similowski Thomas , Cayetanot Florence , Bodineau Laurence 
Published: February 2023

IntroductionCongenital Central Hypoventilation Syndrome, a rare disease caused by PHOX2B mutation, is associated with absent or blunted CO2/H+ chemosensitivity due to the dysfunction of PHOX2B neurons of the retrotrapezoid nucleus. No pharmacological treatment is available. Clinical observations have reported non-systematic CO2/H+ chemosensitivity recovery under desogestrel.MethodsHere, we used a preclinical model of Congenital Central Hypoventilation Syndrome, the retrotrapezoid nucleus conditional Phox2b mutant mouse, to investigate whether etonogestrel, the active metabolite of desogestrel, led to a restoration of chemosensitivity by acting on serotonin neurons known to be sensitive to etonogestrel, or retrotrapezoid nucleus PHOX2B residual cells that persist despite the mutation. The influence of etonogestrel on respiratory variables under hypercapnia was investigated using whole-body plethysmographic recording. The effect of etonogestrel, alone or combined with serotonin drugs, on the respiratory rhythm of medullary-spinal cord preparations from Phox2b mutants and wildtype mice was analyzed under metabolic acidosis. c-FOS, serotonin and PHOX2B were immunodetected. Serotonin metabolic pathways were characterized in the medulla oblongata by ultra-high-performance liquid chromatography.ResultsWe observed etonogestrel restored chemosensitivity in Phox2b mutants in a non-systematic way. Histological differences between Phox2b mutants with restored chemosensitivity and Phox2b mutant without restored chemosensitivity indicated greater activation of serotonin neurons of the raphe obscurus nucleus but no effect on retrotrapezoid nucleus PHOX2B residual cells. Finally, the increase in serotonergic signaling by the fluoxetine application modulated the respiratory effect of etonogestrel differently between Phox2b mutant mice and their WT littermates or WT OF1 mice, a result which parallels with differences in the functional state of serotonergic metabolic pathways between these different mice.DiscussionOur work thus highlights that serotonin systems were critically important for the occurrence of an etonogestrel-restoration, an element to consider in potential therapeutic intervention in Congenital Central Hypoventilation Syndrome patients.
Integration of bulk RNA sequencing and single-cell analysis reveals a global landscape of DNA damage response in the immune environment of Alzheimer’s disease
Authors: Lai Yongxing , Lin Han , Chen Manli , Lin Xin , Wu Lijuan , Zhao Yinan , Lin Fan , Lin Chunjin 
Published: February 2023

BackgroundWe developed a novel system for quantifying DNA damage response (DDR) to help diagnose and predict the risk of Alzheimer’s disease (AD).MethodsWe thoroughly estimated the DDR patterns in AD patients Using 179 DDR regulators. Single-cell techniques were conducted to validate the DDR levels and intercellular communications in cognitively impaired patients. The consensus clustering algorithm was utilized to group 167 AD patients into diverse subgroups after a WGCNA approach was employed to discover DDR-related lncRNAs. The distinctions between the categories in terms of clinical characteristics, DDR levels, biological behaviors, and immunological characteristics were evaluated. For the purpose of choosing distinctive lncRNAs associated with DDR, four machine learning algorithms, including LASSO, SVM-RFE, RF, and XGBoost, were utilized. A risk model was established based on the characteristic lncRNAs.ResultsThe progression of AD was highly correlated with DDR levels. Single-cell studies confirmed that DDR activity was lower in cognitively impaired patients and was mainly enriched in T cells and B cells. DDR-related lncRNAs were discovered based on gene expression, and two different heterogeneous subtypes (C1 and C2) were identified. DDR C1 belonged to the non-immune phenotype, while DDR C2 was regarded as the immune phenotype. Based on various machine learning techniques, four distinctive lncRNAs associated with DDR, including FBXO30-DT, TBX2-AS1, ADAMTS9-AS2, and MEG3 were discovered. The 4-lncRNA based riskScore demonstrated acceptable efficacy in the diagnosis of AD and offered significant clinical advantages to AD patients. The riskScore ultimately divided AD patients into low- and high-risk categories. In comparison to the low-risk group, high-risk patients showed lower DDR activity, accompanied by higher levels of immune infiltration and immunological score. The prospective medications for the treatment of AD patients with low and high risk also included arachidonyltrifluoromethane and TTNPB, respectively,ConclusionsIn conclusion, immunological microenvironment and disease progression in AD patients were significantly predicted by DDR-associated genes and lncRNAs. A theoretical underpinning for the individualized treatment of AD patients was provided by the suggested genetic subtypes and risk model based on DDR.
Risk prediction model based on blood biomarkers for predicting moderate to severe endoscopic activity in patients with ulcerative colitis
Authors: Li Xiaojuan , Tang Zihui , Liu Yanbing , Zhu Xinyan , Liu Fei 
Published: February 2023

ObjectWe explored developing an internal validation model to predict the moderate to severe endoscopic activity of ulcerative colitis (UC) patients based on non-invasive or minimally-invasive parameters.MethodsUlcerative Colitis Endoscopic Index of Severity (UCEIS) and Mayo endoscopic subscore were performed for UC patients who met the criteria from January 2017 to August 2021 through the electronic database of our center. Logistic regression and a least absolute shrinkage and selection operator (Lasso) regression model were performed to screen the risk factors of moderate to severe UC activity. The nomogram was established subsequently. Discrimination of the model was evaluated using the concordance index (c-index), and the calibration plot and 1,000 Bootstrap were used to evaluate the model’s performance and conduct internal validation.ResultsSixty-five UC patients were included in this study. According to UCEIS criteria,45 patients were moderate to severe endoscopic activity. 26 potential predictors of UC were analyzed by logistic and Lasso regression showed that vitamin D (Vit D), albumin (ALB), prealbumin (PAB), and fibrinogen (Fbg) were the best predictors of moderate to severe endoscopic activity of UC. We used these 4 variables to develop a dynamic nomogram prediction model. The c-index was 0.860, which means good discrimination. The calibration plot and Bootstrap analysis showed that the prediction model accurately distinguished the moderate to severe endoscopic activity in UC patients. The prediction model was verified using a cohort of UC patients with moderate to severe activity defined by the Mayo endoscopic subscore, and it was found that the model still had good discrimination and calibration (c-index = 0.891).ConclusionThe model containing Vit D, ALB, PAB, and Fbg was a good tool for evaluating UC activity. The model is simple, accessible, and user-friendly, which has broad application prospects in clinical practice.
Sclerostin, vascular risk factors, and brain atrophy in excessive drinkers
Authors: Martín-González Candelaria , Godoy-Reyes Ana María , Abreu-González Pedro , Fernández-Rodríguez Camino María , Martín-Ponce Esther , Sánchez-Pérez María José , Alvisa-Negrín Julio César , Rodríguez-Gaspar Melchor , González-Reimers Emilio 
Published: February 2023

ObjectiveHeavy alcohol consumption causes several organic complications, including vessel wall calcification. Vascular damage may be involved in the development of brain atrophy and cognitive impairment. Recently, sclerostin (whose levels may be altered in alcoholics) has emerged as a major vascular risk factor. The objective of the present study is to analyze the prevalence of vascular calcifications in alcoholics, and the relationships of these lesions with brain atrophy, as well as the role of sclerostin on these alterations.Patients and methodsA total of 299 heavy drinkers and 32 controls were included. Patients underwent cranial computed tomography, and several indices related to brain atrophy were calculated. In addition, patients and controls underwent plain radiography and were evaluated for the presence or absence of vascular calcium deposits, cardiovascular risk factors, liver function, alcohol intake, serum sclerostin, and routine laboratory variables.ResultsA total of 145 (48.47%) patients showed vascular calcium deposits, a proportion significantly higher than that observed in controls (χ2 = 16.31; p &lt; 0.001). Vascular calcium deposits were associated with age (t = 6.57; p &lt; 0.001), hypertension (t = 5.49; p &lt; 0.001), daily ethanol ingestion (Z = 2.18; p = 0.029), duration of alcohol consumption (Z = 3.03; p = 0.002), obesity (χ2 = 4.65; p = 0.031), total cholesterol (Z = 2.04; p = 0.041), triglycerides (Z = 2.05; p = 0.04), and sclerostin levels (Z = 2.64; p = 0.008). Calcium deposits were significantly related to Bifrontal index (Z = 2.20; p = 0.028) and Evans index (Z = 2.25; p = 0.025). Serum sclerostin levels were related to subcortical brain atrophy, assessed by cella media index (Z = 2.43; p = 0.015) and Huckmann index (ρ = 0.204; p = 0.024). Logistic regression analyses disclosed that sclerostin was the only variable independently related to brain atrophy assessed by altered cella media index. Sclerostin was also related to the presence of vascular calcifications, although this relationship was displaced by age if this variable was also included.ConclusionPrevalence of vascular calcification in alcoholics is very high. Vascular calcium deposits are related to brain atrophy. Serum sclerostin is strongly related to brain shrinkage and also shows a significant relationship with vascular calcifications, only displaced by advanced age.
Patterns of developmental regression and associated clinical characteristics in SLC6A1-related disorder
Authors: Kalvakuntla Sanjana , Lee MinJae , Chung Wendy K. , Demarest Scott , Freed Amber , Horning Kyle J. , Bichell Terry Jo , Iannaccone Susan T. , Goodspeed Kimberly 
Published: February 2023

IntroductionSLC6A1-related disorder is a genetic neurodevelopmental disorder that is caused by loss of function variants in the SLC6A1 gene. Solute Carrier Family 6 Member 1 (SLC6A1) gene encodes for gamma-aminobutyric acid (GABA) transporter type 1 (GAT1), which is responsible for reuptake of GABA from the synaptic cleft. Tight regulation of GABA levels plays an important role in brain development by balancing inhibitory and excitatory neuronal signaling. Consequently, individuals with SLC6A1-related disorder can have manifestations such as developmental delay, epilepsy, autism spectrum disorder, and a subset have developmental regression.MethodsIn this study, we identified patterns of developmental regression among a cohort of 24 patients with SLC6A1-related disorder and assessed for clinical characteristics associated with regression. We reviewed medical records of patients with SLC6A1-related disorder and divided subjects into two groups: 1) regression group and 2) control group. We described the patterns of developmental regression including whether there was a trigger prior to the regression, multiple episodes of regression, and whether or not skills were recovered. We assessed the relationship of clinical characteristics among the regression and control groups including demographic factors, seizures, developmental milestone acquisition, gastrointestinal problems, sleep problems, autism spectrum disorder, and behavioral problems.ResultsIndividuals with developmental regression had a loss of skills that were previously mastered in developmental domains including speech and language, motor, social, and adaptive skills. The mean age at regression was 2.7 years and most subjects had regression of language or motor skills triggered by seizures, infection, or spontaneously. Although there was no significant difference in clinical characteristics between the two groups, there was a higher prevalence of autism and severe language impairment in the regression group.DiscussionFuture studies of a larger cohort of patients are required to make definitive conclusions. Developmental regression is often a sign of severe neurodevelopmental disability in genetic syndromes, but it is poorly understood in SLC6A1-related disorder. Understanding the patterns of developmental regression and the associated clinical characteristics in this rare disorder will be important to medical management, prognostication, and could impact the design of future clinical trials.
The BAP31/miR-181a-5p/RECK axis promotes angiogenesis in colorectal cancer via fibroblast activation
Authors: Zhang Qi , Wang Changli , Li Ruijia , Liu Jingjing , Wang Jiyu , Wang Tianyi , Wang Bing 
Published: February 2023

BackgroundB-cell receptor–associated protein 31 (BAP31) has been recognized as a tumor-associated protein and has largely been shown to promote metastasis in a variety of cancers. Cancer metastasis arises through multistep pathways, and the induction of angiogenesis is shown to be a rate-limiting step in the process of tumor metastasis.Methods and resultsThis study explored the effect of BAP31 on colorectal cancer (CRC) angiogenesis by regulating the tumor microenvironment. First, exosomes from BAP31-regulated CRCs affected the transition of normal fibroblasts to proangiogenic cancer-associated fibroblasts (CAFs) in vivo and in vitro. Next, microRNA sequencing was performed to analyze the microRNA expression profile of exosomes secreted from BAP31- overexpressing CRCs. The results indicated that the expression of BAP31 in CRCs significantly altered the levels of exosomal microRNAs, such as miR-181a- 5p. Meanwhile, an in vitro tube formation assay showed that fibroblasts with high levels of miR-181a-5p significantly promoted endothelial cell angiogenesis. Critically, we first identified that miR-181a-5p directly targeted the 3'-untranslated region (3′UTR) of reversion-inducing cysteine-rich protein with kazal motifs (RECK) using the dual-luciferase activity assay, which drove fibroblast transformation into proangiogenic CAFs by upregulating matrix metalloproteinase-9 (MMP-9) and phosphorylation of mothers against decapentaplegic homolog 2/Mothers against decapentaplegic homolog 3 (Smad2/3). ConclusionExosomes from BAP31-overexpressing/BAP31-knockdown CRCs are found to manipulate the transition of fibroblasts into proangiogenic CAFs by the miR-181a-5p/RECK axis.