bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new kid in the folding funnel: Molecular chaperone activities of the BRICHOS domain
Authors: Leppert Axel , Poska Helen , Landreh Michael , Abelein Axel , Chen Gefei , Johansson Jan 
Published: April 2023

AbstractThe BRICHOS protein superfamily is a diverse group of proteins associated with a wide variety of human diseases, including respiratory distress, COVID‐19, dementia, and cancer. A key characteristic of these proteins—besides their BRICHOS domain present in the ER lumen/extracellular part—is that they harbor an aggregation‐prone region, which the BRICHOS domain is proposed to chaperone during biosynthesis. All so far studied BRICHOS domains modulate the aggregation pathway of various amyloid‐forming substrates, but not all of them can keep denaturing proteins in a folding‐competent state, in a similar manner as small heat shock proteins. Current evidence suggests that the ability to interfere with the aggregation pathways of substrates with entirely different end‐point structures is dictated by BRICHOS quaternary structure as well as specific surface motifs. This review aims to provide an overview of the BRICHOS protein family and a perspective of the diverse molecular chaperone‐like functions of various BRICHOS domains in relation to their structure and conformational plasticity. Furthermore, we speculate about the physiological implication of the diverse molecular chaperone functions and discuss the possibility to use the BRICHOS domain as a blood–brain barrier permeable molecular chaperone treatment of protein aggregation disorders.
Characteristics of the low‐level jets observed over Dunkerque (North Sea French coast) using 4 years of wind lidar data
Authors: Dieudonné Elsa , Delbarre Hervé , Sokolov Anton , Ebojie Felix , Augustin Patrick , Fourmentin Marc 
Published: April 2023

AbstractThis study investigates the occurrence and characteristics of low‐level jets (LLJs) up to 200 m above sea level in the North Sea area, specifically in the southernmost part of the basin, at the entrance of the English Channel. Using a short‐range Doppler lidar installed in Dunkerque Port, on the northern coast of France, wind profiles were recorded for 4 years and analyzed statistically. LLJs were detected on more than 11,000 of the 10‐min average wind profiles (5% of time), with similar jet core height and core speed distributions as in other sites in the southern North Sea area, and a similar annual cycle. However, there were differences in the core directions and the daily cycle, with afternoon northeastly jets being the most frequent in Dunkerque, whereas southwesterly nocturnal jets were dominant in the other North Sea sites. This suggests that wind channeling in the Dover Strait is likely a major factor for LLJ formation in Dunkerque region. The study also examined the conditions of LLJ occurrence using European Centre for Medium‐Range Weather Forecast (ECMWF) reanalysis v5 and ultrasonic anemometer data, but the different types of LLJs sharing the same core direction and occurrence conditions made it difficult to quantify specific jet formation mechanisms. This is the first experimental study on the North Sea shore, and at the entrance of the English Channel, providing valuable insights into the LLJ behavior in the region.
Adaptive fault‐tolerant control of nonlinear systems based on tuning functions
Authors: Qi Hongji , Chen Ming , Wu Libing 
Published: April 2023

AbstractThis article investigates the tracking control problem of adaptive fault‐tolerant control (AFTC) for a class of strict‐feedback nonlinear systems with actuator/sensor faults and unmatched disturbances. The sensor/actuator faults include bias, drift, loss of accuracy, and loss of effectiveness. Our main control objective is to investigate an adaptive fault‐tolerant control algorithm with the help of tuning functions, adaptive control technology, fuzzy logic systems (FLSs) and so on. For unknown nonlinear functions and fault items, FLSs and adaptive control technology are utilized to approximate them. Furthermore, over‐parameterization problem existed in the backstepping‐based controller design is solved by introducing the tuning functions. Theoretical analysis proves that our proposed AFTC scheme can ensure that all the signals in the closed‐loop system are bounded and the tracking error remains within a small range of zero even if a series of faults mentioned above occur. In the end, the simulation results show that the presented AFTC strategy is feasible and effective.
Efficient min–max MPC: Achieving a large domain of attraction with short horizon
Authors: Nguyen Hoai‐Nam 
Published: April 2023

AbstractThis article considers the regulation problem of a constrained linear system with bounded disturbance. The objective is to overcome the offline and online problems of the standard dual‐mode min–max model predictive control (MPC). The offline problem is related to the construction of a polyhedral terminal set, which is prohibitively complex especially for high order systems. We propose to replace the polyhedral set with the ellipsoidal one, which is much easier to construct. The online problem is related to the computational burden, which grows exponentially with the prediction horizon . We show how to employ a new terminal cost function, that results in a new min–max MPC with a large domain of attraction even with or . Hence the computational complexity is drastically reduced. Two numerical examples with comparison to earlier solutions from the literature illustrate the effectiveness of the proposed approach.
Achieving environmental sustainability in Africa: The role of financial institutions development on carbon emissions
Authors: Chen George S. , Manu Emmanuel Kwaku , Asante Dennis 
Published: April 2023

AbstractWe investigate the causal impact of the development of financial institutions on environmental sustainability in Africa. Drawing on a distinctive panel data set encompassing 34 countries from 1980 to 2017, with carbon emissions serving as an indicator of environmental sustainability, we discover that enhanced development of financial institutions leads to increased carbon emissions, especially in relation to the depth of these institutions. Furthermore, our study reveals support for the environmental Kuznets curve, heterogenous slopes, and shifts over time in the finance–emissions nexus. Our results remain robust to different model specifications. The conclusions we reach indicate that the development of financial institutions and the implementation of pro‐growth policies are essential for attaining environmental sustainability on the African continent.
Tween‐85 Surfactant‐Assisted Fabrication of Silver Monoliths for Catalytic Reduction of Methyl Orange and Caffeine Sensing
Authors: Nema Ankita , Bano Mustri , Rai Mansi , Shrivastava Kavya , Dangi Sambhavna S. , Khan Farid 
Published: April 2023

AbstractAn elegant method (modified sol‐gel method) was developed to fabricate porous silver (Ag) monoliths using Tween‐85 (T‐85) as a reducing agent with and without dextran (Dex) and TiO2nanoparticles (TiO2NPs) for heterogeneous catalysis for the reduction of methyl orange (MO) using sodium borohydride (NaBH4), as reducing agent and also sensor against caffeine. Ag/Tween‐85/Dextran/TiO2NPs (Ag/T‐85/Dex/TiO2NPs) catalyst was characterized by thermogravimetric analysis (TGA), X‐ray photoelectron spectroscopy (XPS), X‐ray diffraction (XRD), UV‐Vis spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM), Brunauer‐Emmett‐Teller (BET) adsorption isotherm technique, and Fourier transform infrared (FTIR) analysis. Porous Ag/T‐85/Dex/TiO2NPs monolith degraded toxic dye methyl orange just in 25 seconds (s) which is the minimum time reported. Cyclic voltammetry (CV) using modified carbon paste electrode (CPE) together with Ag/AgCl as reference and pt as counter electrodes with 0.1 mH2SO4as supporting electrolyte were used. Ag/T‐85/Dex/TiO2NPs−CPE acts as a sensor against caffeine with a limit of detection (LOD) and limit of quantization (LOQ) 0.654 ng mL−1and 0.876 ng mL−1respectively and sensitivity is 0.236 μA/mm/cm2.
Antimicrobial and Molecular Docking Studies of Novel Synthesized α‐Aminophosphonates Based on Pyrozol Moiety as Anticancer Agents via α‐Topoisomerase II Inhibition
Authors: Mandour Hamada S. A. , Hamed Mohamed A. , Saad‐Allah Khalil M. , Abd Elnabi Manar K. , Abosharaf Hamed A. , El‐Gharably Atif A. 
Published: April 2023

AbstractThe reaction of (1,3‐diphenyl‐1H‐pyrazole‐4‐carbaldehyde) with different aromatic amines and triethylphosphite in the presence of magnesium perchlorate as a catalyst resulted in high yields of new α‐aminophosphonates containing pyrazole moiety. The structures of the newly prepared α‐aminophosphonates were confirmed using IR, elemental analysis, 1H NMR, and 13C NMR spectra. The antibacterial analysis of the prepared compounds showed potential inhibitory effects against the selected bacterial strains with minimal inhibitory concentrations (MIC) ranging from 12.5 to 3.125 mg/mL compared to the start compound. Some compounds have exhibited higher DPPH scavenging activity. Further, the molecular docking studies illustrated that the synthesized compounds have an inhibitory effect against topoisomerase II, which targets many approved drugs. The best modified α‐aminophosphonates compound had the highest binding affinity, with a value of −7.57 kcal/mol. Modified α‐aminophosphonates can be employed as a feasible starting point for generating new antimicrobial and anticancer agents and incorporating new reducing agents into therapeutic formulations.
Enzymatic Catalysis in Size and Volume Dual‐Confined Space of Integrated Nanochannel‐Electrodes Chip for Enhanced Impedance Detection of Salmonella
Authors: Li Yue , Ma Xinyue , Zhu Wenyue , Huang Qiao , Liu Yameng , Pan Jinming , Ying Yibin , Xu Xiahong , Fu Yingchun 
Published: April 2023

AbstractNanochannel‐based confinement effect is a fascinating signal transduction strategy for high‐performance sensing, but only size confinement is focused on while other confinement effects are unexplored. Here, a highly integrated nanochannel‐electrodes chip (INEC) is created and a size/volume‐dual‐confinement enzyme catalysis model for rapid and sensitive bacteria detection is developed. The INEC, by directly sandwiching a nanochannel chip (60 µm in thickness) in nanoporous gold layers, creates a micro‐droplet‐based confinement electrochemical cell (CEC). The size confinement of nanochannel promotes the urease catalysis efficiency to generate more ions, while the volume confinement of CEC significantly enriches ions by restricting diffusion. As a result, the INEC‐based dual‐confinement effects benefit a synergetic enhancement of the catalytic signal. A 11‐times ion‐strength‐based impedance response is obtained within just 1 min when compared to the relevant open system. Combining this novel nanoconfinement effects with nanofiltration of INEC, a separation/signal amplification‐integrated sensing strategy is further developed for Salmonella typhimurium detection. The biosensor realizes facile, rapid (<20 min), and specific signal readout with a detection limit of 9 CFU mL−1 in culturing solution, superior to most reports. This work may create a new paradigm for studying nanoconfined processes and contribute a new signal transduction technique for trace analysis application.
Triple Tumor Microenvironment‐Responsive Ferroptosis Pathways Induced by Manganese‐Based Imageable Nanoenzymes for Enhanced Breast Cancer Theranostics
Authors: He Haozhe , Du Lihua , Xue Hongman , An Yongcheng , Zeng Kejing , Huang Huaping , He Yulong , Zhang Changhua , Wu Jun , Shuai Xintao 
Published: April 2023

AbstractPrevious studies have found that activated CD8+ T cells secrete elevated levels of interferon‐gamma (IFN‐γ) to trigger ferroptosis in tumor cells. However, IFN‐γ‐mediated ferroptosis is induced at low levels in tumor cells because of the limited IFN‐γ secreted by CD8+ T cells in the immunosuppressive tumor microenvironment. Recent studies have shown that manganese ion can activate the cyclic guanosine monophosphate‐adenosine monophosphate (GMP–AMP) synthase/stimulator of interferon genes (cGAS‐STING) pathway and support adaptive immune responses against tumors, which enhances the level of tumor‐infiltrating CD8+ T cells. Therefore, tumor microenvironment‐responsive Mn‐based nanoenzymes (Mn‐based NEs) that activated the cGAS‐STING pathway are designed to amplify immune‐driven ferroptosis. The multifunctional all‐in‐one nanoplatform is simply and mildly synthesized by the coordination between Mn3+ ions and 3,3′‐dithiodipropionic acid. After intracellular delivery, each component of Mn‐based NEs exerts its function. That is, glutathione is depleted through disulfide–thiol exchange and redox pair of Mn3+/Mn2+, a hydroxyl radical (·OH) is generated via the Fenton‐like reaction to cause ferroptosis, and Mn2+ augments cGAS‐STING activity to boost immune‐driven ferroptosis. In addition, ferroptosis amplifies Mn2+‐induced immunogenic cell death and initiates the antitumor immune “closed loop” along with immune‐driven ferroptosis. Notably, this multifunctional nanoplatform is effective in killing both primary and distant tumors.
Efficient and Stable P–N Homojunction Perovskite Solar Cells Using ALD–Alumina Interface Layer
Authors: Chavan Rohit D. , Prochowicz Daniel , Mahapatra Apurba , Tavakoli Mohammad Mahdi , Yadav Pankaj , Hong Chang Kook 
Published: April 2023

(DOI: 10.1002/solr.202300174)The above article, first published online as an accepted article on 25 April 2023 in Wiley Online Library (wileyonlinelibrary.com), has been withdrawn by agreement between the authors, the Editor‐in‐Chief Anna Troeger, and Wiley‐VCH Verlag GmbH.The authors requested a withdrawal due to problems with the reproducibility of the reported experimental data.
The systems approach of strategic roadmapping: Framing challenges and contributions whilst flexing to changing conditions and circumstances
Authors: Kerr Clive 
Published: April 2023

AbstractFor supporting strategy development, corporate practitioners and consultants have long appropriated the roadmap metaphor for journey‐making to establish the concept of strategic roadmapping. The practice involves charting future courses of action to help realize a vision. However, despite the significant uptake and use of the method, there still lacks a discourse on its inherent flexibility. Therefore, this paper outlines roadmapping's flexible nature from a systems perspective. The key attributes of the approach being general, scalable, customizable and dynamic are characterized. The governing framework underpinning roadmapping is depicted and described. To provide guidance on deploying this framework, two critical aspects are covered: (i) framing the challenges being faced and contributions necessary to move forward and (ii) with specific regard to having to deal with the realized unfolding of time, the need to flex to evolving conditions and new situational circumstances.
The effect of different processing methods of linseed on growth performance, nutrient digestibility, blood parameters and ruminate behaviour of lambs
Authors: Hossein Abadi Mostafa , Ghoorchi Taghi , Amirteymouri Elham , Poorghasemi Mohammadreza 
Published: April 2023

AbstractBackgroundOilseeds such as linseed, canola and sunflower contain unsaturated fatty acids that play important functions in the body. The aim of this study was to assess the effects of different levels of processing linseed on growth performance, nutrient digestibility, blood parameters and ruminate behaviour of lambs.MethodsFifty‐six Moghani male lambs (3 months of age, initial average body weight = 28 ± 1.2 kg) were allocated to seven experimental diets in randomized design (eight lambs per each treatment). The experimental diets were as follows: (1) control diet (without linseed), (2) 5% raw linseed, (3) 10% raw linseed, (4) 5% micronized linseed, (5) 10% micronized linseed, (6) 5% extruded linseed and (7) 10% extruded linseed. Lambs were fed ad libitum a basal diet as total mixed ration consisting of 25% concentrate and 75% hay.ResultsThe results showed that linseed level and processing method had no significant effect on dry matter intake. Average daily gain, final body weight and feed conversion ratio (FCR) in lambs were affected by experimental diets. The use of 10% micronized linseed and 10% of extruded linseed in the lambs’ diet improved dry matter and crude protein digestibility significantly (p< 0.001). Blood glucose concentration observed for lambs fed 10% of micronized or extruded linseed (LS) was not different from that observed in other groups, only from the values shown by lambs fed diets 1 (control) and 2 (5% raw LS). The lowest cholesterol and the highest blood urea nitrogen concentrations were related to lambs fed the control diet (p< 0.001). Feeding processed linseed relative to control diet had no effect on feeding behaviour in lambs.ConclusionResults of this research showed that the use of extruded and micronized linseed at the level of 10% can improve FCR, nutrient digestibility, and blood parameters.
Soil thermal properties during freeze–thaw dynamics as function of variable organic carbon and grain size distribution
Authors: de Bruin Jelte G. H. , Bense Victor F. , van der Ploeg Martine J. 
Published: April 2023

AbstractPermafrost regions are experiencing increasing air temperatures, accelerating the thawing process, and thickening the active layer in summer. This can accelerate the release of greenhouse gasses into the atmosphere from the organic carbon stored in the permafrost. The long‐term thawing rates of permafrost below the active layer are governed by the soil thermal properties, the heat capacity, and thermal conductivity, which vary due to differences in grain sizes and distribution and organic matter content. Using nine column experiments comprised of fully saturated synthetic permafrost samples exposed to freeze–thaw cycles, the relative contributions of a range of soil grain sizes and organic matter contents on the soil thermal properties were investigated. The columns were subjected to a freeze and thaw cycle while soil temperatures were recorded in profiles. To infer the thermal properties from these experimental data, a numerical heat transfer model was used. The best fit between the observations and a batch of 5544 numerical models was used to find optimum values for permafrost thermal properties. The optimized heat capacity varied between 500 and 650 (J/m3 K) and thermal conductivity between 2.45 and 3.55 (W/m K). These optimized parameters were subsequently used to model a 100‐year permafrost active layer thaw scenario under warming air temperatures. Variations in the optimized thermal properties resulted in a time difference in thawing depth of 10–15 years and thawing depths varied between 9 and 10 m between the different optimized thermal properties at the end of the 100‐year scenario.
Convergences and Divergences in Career Paths: Recruiting Foreign Teachers in Binational Schools in Argentina
Authors: Mayer Liliana , Gottau Verónica 
Published: April 2023

AbstractThis chapter seeks to analyze the reasons why binational schools house foreign native speakers’ teachers as part of their staff and the reasons that make foreign residents work in binational schools in Argentina. We developed a multiple case design to predict similarities or contrasts based on arguments that explain these differences (Yin, Case study research: design and methods. Sage, Thousand Oaks, 2003) and conducted 15 in-depth interviews with educational agents – teachers and authorities – from binational schools, between 2017 and 2020.Our findings show that divergences in ‘career paths’ are marked by different contracting mechanisms: while foreign teachers are recruited through specific networks and enjoy economic privileges similar to diplomatic corps, Argentine teachers receive their salary in the local currency and according to national parameters. From these material advantages other symbolic ones will land. By creating a sense of belonging to an endogroup, some foreign teachers have the power to set the values and identities that create meaning within the school. This ‘minority though elite’ group of teachers finds a fertile soil in the school ethos of binational schools, closely in line with cultural diplomacy. We conclude that binational schools tend to legitimate their added value through the hiring of foreign teachers, and foreign teachers find solid ground for a successful career path, granted by their place of birth, and by the credentials derived from educational paths that have proved to be advantageous for specific institutional projects.
The Growth of Minority Supervisors: Supervision of Pre-service Teachers’ Field Experiences
Authors: Xiao Bing 
Published: April 2023

AbstractThe anthropologists are outsiders to the culture who were studying in traditional ethnography. I understand this since I identify as both an insider and an outsider when I instruct, supervise, and advise my American students. I am an “insider” in the teacher education program but an “outsider” of American school culture. I am originally from China, but I am immersing myself in my doctoral studies in the American education system. I instruct teaching methods classes and have served as a supervisor for students’ field experiences for around ten years. As a minority educator, I am faced with multiple challenges, especially supervising student teachers. The purpose of this chapter will explore the challenges of the minority supervisors’ growth and those influences on pre-service teachers. The research used the video-cued multivocal ethnographic method. I conducted focus-group interviews with university supervisors and the instructors of a teaching methods course. I presented video clips from students’ field teaching experience to the interviewees and discussed how videos impact teaching and teacher preparation notions. Additional data comes from my own experience. The chapter expands on Foucault and Bourdieu’s work to better understand how power flows in the field experience and how power changes supervisors’ and pre-service teachers’ habitus and behaviors. It also draws from Latour’s Actor-Network Theory (ANT) theoretical lens to investigate how different actors, such as the university, local schools, mentor teachers, supervisors, and pre-service teachers, change their action transforms the field experience.
3D-Printed MWF Nozzles for Improved Energy Efficiency and Performance During Grinding
Authors: Zmich Robert , Heinzel Carsten 
Published: April 2023

AbstractParticularly during grinding of metal workpieces, a high energy consumption is required during the main process times, so that the resulting energy costs represent a significant amount of the total operating costs of the machine tool. In this context, the supply of metal working fluids (MWF) during the grinding process is often associated with a high energy consumption, but the MWF supply strategy (MWF flow rate, MWF nozzle, control and dimensioning of the MWF supply pumps) can significantly influence the energy efficiency of such processes. In the scope of this work, additive manufacturing was used to produce fluid supply nozzles adapted to the respective grinding process. In this work, it was shown that by using a flow-optimized nozzle the required power of the MWF supply pump can be significantly reduced, allowing to make the grinding process more efficient in terms of the energy required.