bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of onchocerciasis among adolescents in nkwanta north district of Ghana: Qualitative study of adolescents’ perception, community and health system support
Authors: Gbogbo Sitsofe , Amu Hubert , Dowou Robert Kokou , Ayanore Martin Amogre 
Published: August 2023

Background
Onchocerciasis affects the quality of life to a greater extent among affected individuals. The World Health Organization (WHO)’s Onchocerciasis Control Program (OCP) has effectively reduced the prevalence of onchocerciasis by interrupting the transmission of the parasite and by mass population treatment in the regions at risk of the disease. Despite the successful reduction of the prevalence of onchocerciasis by WHO, the socioeconomic burden resulting from the disabilities caused by onchocerciasis are still immense. This study sought to explore the adolescents’ perception regarding the management of onchocerciasis, community and health system support in Nkwanta North District of Ghana.

Method
This study adopted a qualitative phenomenological design and exploratory, descriptive qualitative approach. An in-depth interview guide was developed to collect data for the study. One-on-one interview was conducted. Data collected from 16 onchocerciasis adolescent patients were analysed thematically using ATLAS.ti v7.5.7. Quotes from the participants were presented verbatim to substantiate the themes realised.

Results
Most of the 12 participants (75.0%) were aged 15–18 years old. It was noted that 6(37.50%) of participants were in Junior High School (JHS), while 4(25.0%) were in Senior High School (SHS). It was noted that community members have diverse understandings and perceptions of onchocerciasis, including beliefs that Onchocerciasis is a serious disease that can cause blindness; it is caused by the consumption of some types of food products or stressful work. Adolescents believed that onchocerciasis was caused by insect bite blood infection, poor environmental hygiene, sun or could have been inherited from parents. Ivermectin treatment was noted by adolescents to have helped relieve the symptoms of ochocerciasis they were experiencing. However, the adolescents indicated that they had experienced some side effects, including fever, headache, body itching, rushes, swollen body and blurred vision from the drug.

Conclusion
Inadequate education and communication about onchocerciasis resulted in diverse and erroneous meanings of onchocerciasis among community members. Our research recognises that community and health system supports is very important in the effective management of Onchocerciasis, contributing to the attainment of Sustainable Development Goal (SDG) 3.3, which is targeted at ending the epidemic of NTDs like onchocerciasis by 2030.
Correlation of a commercial platform’s results with post-vaccination SARS-CoV-2 neutralizing antibody response and clinical host factors
Authors: Slotkin Rebecca , Kyriakides Tassos C. , Kundu Anupam , Stack Gary , Sutton Richard E. , Gupta Shaili 
Published: August 2023

Introduction
The objective of this study was to describe the correlation between the commercially available assay for anti-S1/RBD IgG and protective serum neutralizing antibodies (nAb) against SARS-CoV-2 in an adult population after SARS-CoV-2 vaccination, and determine if clinical variables impact this correlation.

Methods
We measured IgG anti-S1/RBD using the IgG-II CMIA assay and nAb IC50 values against SARS-CoV-2 WA-1 in sera serially collected post-mRNA vaccination in veterans and healthcare workers of the Veterans Affairs Connecticut Healthcare System (VACHS) between December 2020 and January 2022. The correlation between IgG and IC50 was measured using Pearson correlation. Clinical variables (age, sex, race, ethnicity, prior COVID infection defined by RT-PCR, history of malignancy, estimated glomerular filtration rate (GFR calculated using CKD-EPI equation) were collected by manual chart review. The impact of these clinical variables on the IgG-nAb correlation was analyzed first with univariable regression. Variables with a significance of p < 0.15 were analyzed with forward stepwise regression analysis.

Results
From 127 sera samples in 100 unique subjects (age 20–93 years; mean 63.83; SD 15.63; 29% female; 67% White), we found a robust correlation between IgG anti-S1/RBD and nAb IC50 (R2 = 0.83, R2adj = 0.70, p < 0.0001). Race, ethnicity, and a history of malignancy were not significant on univariable analysis. GFR (p < 0.05) and prior COVID infection (p < 0.001) had a significant impact on the correlation between IgG anti-S1/RBD and nAb IC50. Age (p = 0.06) and sex (p = 0.07) trended towards significance on univariable analysis, but were not significant on multivariable regression.

Conclusions
There was a strong correlation between IgG anti-S1/RBD and nAb IC50 after SARS-CoV-2 vaccination. Clinical comorbidities, such as prior COVID infection and renal function, impacted this correlation. These results may assist the prediction of post-vaccination immune protection in clinical settings using cost-effective commercial platforms.
Balance Training Under Fatigue: A Randomized Controlled Trial on the Effect of Fatigue on Adaptations to Balance Training
Authors: Keller Martin , Lichtenstein Eric , Roth Ralf , Faude Oliver 
Published: August 2023

Abstract
Keller, M, Lichtenstein, E, Roth, R, and Faude, O. Balance training under fatigue: a randomized controlled trial on the effect of fatigue on adaptations to balance training. J Strength Cond Res 38(2): 297–305, 2024—Balance training is an effective means for injury prevention in sports. However, one can question the existing practice of putting the balance programs at the start of a training session (i.e., train in an unfatigued state) because the occurrence of injuries has been associated with fatigue. Therefore, the aim of this study was to assess the influence of balance training in a fatigued or an unfatigued state on motor performance tested in fatigued and unfatigued conditions. Fifty-two, healthy, active volunteers (28.0 years; 19 women) were randomly allocated to 1 of 3 different training groups. The BALANCE group completed 6 weeks of balance training. The other 2 groups completed the identical balance tasks either before (BALANCE-high-intensity interval training [HIIT]) or after (HIIT-BALANCE) a HIIT session. Thus, these groups trained the balance tasks either in a fatigued or in an unfatigued state. In PRE and POST tests, balance (solid ground, soft mat, wobble board) and jump performance was obtained in fatigued and unfatigued states. Balance training resulted in reduced sway paths in all groups. However, the linear models revealed larger adaptations in BALANCE-HIIT and BALANCE when compared with HIIT-BALANCE (d = 0.22–0.71). These small to moderate effects were—despite some uncertainties—consistent for the “unfatigued” and “fatigued” test conditions. The results of this study revealed for the first time that balance training under fatigue results in diminished adaptations, even when tested in a fatigued state. Therefore, the data indicate that balance training should be implemented at the start of a training session or in an unfatigued state.
A perfekcionista énbemutatás jellemzői magyar tanulók körében
Authors: Nagy-Szabó Zoltán , D. Molnár Éva 
Published: August 2023

Háttér és célkitűzésekA perfekcionista énbemutatás viszonylag kevésbé kutatott területnek számít a perfekcionizmus szakirodalmában. Azokat a személyközi megnyilvánulásokat foglalja magában, melyekkel a perfekcionisták a saját megítélésüket próbálják javítani (pl. környezetük előtt elrejtik tökéletlenségeiket, egy idealizált képet mutatnak magukról). Kutatásunk célja az volt, hogy megvizsgáljuk a perfekcionista énbemutatás összefüggéseit a társas önértékeléssel, az önhátráltatással, valamint a tanulmányi elégedettséggel és néhány családi háttértényezővel, hogy ezáltal komplexebb képet kapjunk a perfekcionista viselkedés jellemzőiről.MódszerAz adatgyűjtés 2019 szeptemberétől decemberig tartott, és 192 középiskolás diák vett benne részt online (N = 124) és papír (N = 68) alapon. Kérdőívcsomagunk a perfekcionista énbemutatás (PSPS-JR, 2011), a társas önértékelés (SSES, 2011) és az iskolai önhátráltatás (ASHS, 2001) magyarra fordított változatait, valamint 11 iskolai elégedettséggel és továbbtanulással kapcsolatos kérdést tartalmazott.EredményekA kutatáshoz használt kérdőívek jóságmutatói mind megfelelőek voltak. A perfekcionista énbemutatás mindhárom dimenziója direkt hatással van a tanulók társas önértékelésére, amit az önhátráltatás mediáló hatása nem befolyásol. A perfekcionista énbemutatás a 14–15 évesek körében volt a legjellemzőbb, és a lányok mutatták a legmagasabb értékeket a hibák elrejtése alskálán. Az önhátráltatás magasabb énreklámozással, hibák elrejtésével és alacsonyabb iskolai elégedettséggel járt együtt. A pozitív tanulmányi attitűd (iskolába járás szeretete, jó jegy fontossága, iskolai teljesítménnyel való elégedettség, továbbtanulási szándék) az énreklámozásnak pozitív, az önhátráltatásnak negatív előrejelzője.KövetkeztetésekEredményeink alapján a perfekcionista énbemutatás társas önértékelésre gyakorolt direkt hatása miatt érdemes a jövőben nagyobb hangsúlyt fektetni a perfekcionista énbemutatás társas aspektusainak feltárására.
Sighting of Orange-Headed Thrush Geokichla citrina at Shekha Wetland: An Important Bird Area, Aligarh, Uttar Pradesh, India
Authors: Iqbal Shahzada , Mehta Amee , Beig Mirza Altaf 
Published: August 2023

Thi note reports the sighting on the 8 February 2020 of Orange-Headed Thrush Geokichla citrina at Shekha Wetland (27°51'21" N and 78°13'05" E), Aligarh District, Uttar Pradesh, India.
Circulating microRNA in Myasthenia gravis (MG)
Authors: Punga Anna , Punga Tanel 
Published: August 2023

One of the main difficulties in predicting the clinical course of Myasthenia Gravis (MG) is the heterogeneity of the disease, where disease progression differs greatly depending on the patient's subgroup. MG subgroups are classified according to the age of onset [early onset MG (EOMG; onset ≤ 50 years) versus late-onset MG (LOMG; onset >50 years]; the presence of a thymoma (thymoma associated MG), antibody subtype [acetylcholine receptor antibody seropositive (AChR+), muscle-specific tyrosine kinase antibody seropositive (MuSK+)], or presence of antibodies against low-density lipoprotein receptor-related protein 4 (Lrp4) or agrin as well as clinical subtypes (ocular versus generalized MG). The diagnostic tests for MG, such as antibody titers, neurophysiological tests, and objective clinical fatigue scores, do not necessarily reflect disease progression. Hence, there is a great need for reliable, objective biomarkers in MG to follow the disease course and the individualized response to therapy toward personalized medicine. In this regard, circulating microRNAs (miRNAs) have emerged as promising potential biomarkers due to their accessibility in body fluids and unique profiles in different diseases, including autoimmune disorders. Several studies on circulating miRNAs in MG subtypes have revealed specific miRNA profiles in patient sera. In generalized AChR+ EOMG, miR-150-5p and miR-21-5p are the most elevated miRNAs, with lower levels observed upon treatment with immunosuppression and thymectomy. In AChR+ generalized LOMG, miR-150-5p, miR-21-5p, and miR-30e-5p levels are elevated and decreased by the clinical response after immunosuppression. In ocular MG, higher levels of miR-30e-5p discriminate patients who will later generalize from those remaining ocular. In contrast, in MuSK+ MG, the levels of the let-7 miRNA family members are elevated. Studies of circulating miRNA profiles in Lrp4 or agrin antibody seropositive MG are still lacking. This review summarizes the present knowledge of circulating miRNAs in different subgroups of MG.
MiR-146a in myasthenia gravis thymus: from uncontrolled innate immunity to B cell-mediated autoimmunity
Authors: Cavalcante Paola , Tarasco Maria Cristina , Iacomino Nicola , Antozzi Carlo , Mantegazza Renato 
Published: August 2023

The thymus is the main site of autoimmunity development in myasthenia gravis (MG) associated with anti-acetylcholine receptor (AChR) autoantibodies, a prototypic autoimmune disease affecting neuromuscular junction. Most MG patients with early-onset disease presents follicular hyperplastic changes of the thymus, that are critically implicated in the initiation and perpetuation of the autoimmune response against the AChR. Uncontrolled activation of Toll-like receptor (TLR)-mediated innate immune responses, chronic inflammation and ectopic germinal center (GC) formation are key pathological features of hyperplastic thymus in MG, indicating that a close link between innate immunity and B cell-mediated autoimmunity underlies the intra-thymic pathogenesis of MG.
MiR-146a, an “immune-miR” acting as key modulator of both innate and adaptive immunity, is a potent inhibitor of TLR signaling pathways, able to prevent and avoid an overstimulation of the inflammatory response by targeting the NF-κB signaling transducers IRAK1 and TRAF6. At the same time, miR-146a modulates the expression of c-REL, ICOS and ICOSL, which are crucial regulators of B cell function and GC response. Dysregulation of miR-146a expression is a common molecular event in several autoimmune disorders. Our recent findings revealed defective expression of miR-146a, associated with over-expression of its TLR- and B cell-related target genes, in follicular hyperplastic MG thymuses, indicating that loss of regulatory functions of this miRNA may significantly contribute to the immunopathological steps leading to MG. Of note, corticosteroids were found to increase the miR-146a expression levels, thus suggesting the miRNA capacity to mediate the effects of these drugs in inducing immunosuppression and autoimmunity control.
In this review, we discuss the role of miR-146a as a molecular bridge between innate and adaptive immunity, and summarize the current knowledge on the miRNA contribution to the pathogenesis of MG. Based on our and literature data, we highlight the miR-146a potential as biomarker for therapeutic monitoring, as well as target of future advanced RNA-based therapies to modulate the immune system and counteract the autoimmune response in MG.
Myasthenia research over the last 50 years – a personal perspective
Authors: Vincent Angela 
Published: August 2023

Myasthenia gravis (MG) research has, in many respects, been a trail blazer for the growing number of autoantibody-mediated disorders that affect the nervous system. The breakthroughs in MG understanding were made in the 1970s and even 50 years later, MG still remains a topic which scientists, clinicians and, most recently Pharma, return to as the most common and well-studied disorder. Here, some of the main discoveries will be reviewed very briefly focusing on how the knowledge of the disease evolved during the first decades after the discovery of acetylcholine receptor antibodies. It should be noted that this is a personal perspective and not a systematic or fully referenced review.
The correlation between metabolic syndrome and calcium urolithiasis
Authors: Abdulla Adil , Das Shanmugha , V. Venugopalan A. , T. Rajeevan A. , M. Manikandan 
Published: August 2023

Background: Urolithiasis affects about 12% of the global population. This study helps us to find the correlation between metabolic syndrome, its components and the risk of calcium stone urolithiasis.
Methods: A cross-sectional study was conducted on 140 patients who underwent surgery for urolithiasis and whose stones were calcium-containing. A group of subjects who never had a history of urolithiasis was taken as control. Various anthropometric and biochemical parameters were studied to estimate and compare the prevalence of metabolic syndrome in both the groups.
Results: The study showed that the central obesity of the study population was higher. However, even though prevalence of hypertension was more in the stone group compared to the control population, this difference was not statistically significant. On analysis of biochemical parameters like fasting blood sugar, triglycerides and HDL, abnormal triglycerides and HDL were significantly higher in the stone group when compared to the control. On consideration of all parameters as per international diabetes federation (IDF) definition, prevalence of metabolic syndrome in stone group was 40% which was higher than the control group with 25% and the difference was statistically significant. While summing up the number of parameters of metabolic syndrome an individual has in each group it is evident that the proportion of patients in the stone group had a greater number of parameters compared to the control group.
Conclusions: This study could conclude that there is a significant correlation between calcium urolithiasis and metabolic syndrome.
Traumatological emergencies: epidemiological and problematic aspects of care in the orthopedics traumatology department of the CHU Ignace Deen in Conakry
Authors: Camara Tafsir , Bah Mohamed Lamine , Sidibe Mohamed , Sylla Fode Mahamoud , Madjirabe Hippolyte Nassaaradenger , Bah Mamadou Alpha , Youla Mohamed , Keita Karinka , Diallo Mamadou Moustapha , Lamah Leopold 
Published: August 2023

Background: A trauma emergency is any aggression (direct or indirect) external to the body for which no therapeutic delay is allowed at the risk of endangering the patient's life or the functional prognosis of his limbs. The objective of this study was to report the results of the management of traumatological emergencies.
Methods: This was a descriptive cross-sectional study from 11 January 2021, to 11 July 2021. It focused on patients seen for traumatological emergencies in the CHU Ignace Deen Orthopaedics-Traumatology department.
Results: Trauma emergencies constitute 75.2% of admissions to the emergency department. The average age of the patients was 32.2 years, with extremes of 1 and 91 years. There was a predominance of 76.3% males with a ratio (M/F) of 3.2. Road traffic accidents were the most found aetiology in 82.9%, and motorcycles were involved in 68.7%. Limb fractures were found in 34.7%. The treatment time was ≤6 hours in 67.5%, and 203 patients received drug treatment, i.e., 49.7%.
Conclusions: Trauma emergencies constitute, by their frequency and seriousness, a real public health problem in Africa in general and in Guinea in particular.
Memória jornalística e protagonismo feminino
Authors: Del Vecchio de Lima Myrian Regina , Silva Santos Claudia , Cordeiro Rasera Rafaela 
Published: August 2023

Este trabalho investigou o protagonismo das jornalistas mulheres durante um período da história da Gazeta do Povo, jornal paranaense centenário, que foi o último do estado a contratar mulheres para trabalhar na redação. O objetivo foi salientar, como memória jornalística, os marcos que essas mulheres deixaram no jornal. Uma pesquisa exploratória permitiu ter como premissa que, de forma muito gradativa, jornalistas pioneiras modificaram a estrutura do jornal, ao introduzir inovações editoriais e alcançar cargos de gestão na redação. A seguir foram coletados depoimentos de dez jornalistas que tiveram papeis protagonistas no jornal, para verificar se elas se reconheciam como parte desses feitos. A pesquisa, de caráter qualitativo, foi realizada por meio de revisões bibliográficas e entrevistas em profundidade com as jornalistas, com as informações recolhidas analisadas de forma interpretativa, a partir de duas categorias: protagonismo e desigualdades de gênero na redação. Os resultados mostram mulheres que provocaram mudanças importantes no jornal, mas com dificuldades em perceber seu protagonismo. Concluímos ainda que essas jornalistas vivenciaram algumas condições de desigualdade de gênero no trabalho.
Prevalence of Malnutrition in India: A Disturbing Phenomenon
Authors: Ojha Ruby 
Published: August 2023

The level of economic development or even the adequacy of food at household levels, are no guarantees for a stable and satisfactory nutritional status. This emphasizes the complexity of the problem and the need for tackling the Nutrition Policy consciously and at several levels simultaneously and also in terms of fitting it in the overall development strategy of the country.Â There is no doubt that impressive gains of green revolution have resulted in national food security and have brought the country out of the situations of extreme hunger and starvation but the extent of malnutrition in the country also cannot be ignored. Economic growth alone, though impressive, will not reduce malnutrition sufficiently to meet the nutrition target. It is important to tackle the problem of nutrition both through direct nutrition intervention for especially vulnerable groups as well as through various development policy instruments which will create conditions for improved nutrition.Classification-JEL:I115
TURISMO REGENERATIVO
Authors: Flemming Renata Marcondes Bastos Pereira , Moreira Jasmine Cardozo , Albach Valéria de Meira , Forbeck Guilherme 
Published: August 2023

This article is about Regenerative Tourism, which deals with the relations of human beings with themselves, with others and with nature in a holistic and sustainable way. This is a case study about the Refúgio das Curucacas, Ponta Grossa/PR, in order to analyze if this is regenerative tourism example. The methodology includes the use of bibliographical references, field trips, interview with the owner, and a comparison was made between the paradigms of regenerative tourism and the characteristics currently present at Refúgio das Curucacas. It can be concluded that there is the adequacy of the five items presented as pillars of regenerative planning: ethics and aesthetics, regenerative relationships, sense of place, organic identity and design. Standing out, in camping and tour operator activities, is the design of regenerative experiences such as the Forest Bath, Yoga and Permaculture. Results show that there is regenerative tourism at Refúgio das Curucacas.
APRENDENDO E ENSINANDO
Authors: Bispo Marcileia Oliveira 
Published: August 2023

Este artigo é resultado de uma pesquisa realizada no Programa de Pós-graduação em Geografia da Universidade Federal do Tocantins, campus de Porto Nacional, no período de 2015 a 2023, relacionada as dissertações de mestrado por mim orientadas, que se encontram num período de dez (10) anos do programa. Este trabalho tem como objetivos: apresentar as pesquisas de mestrado e pós-doutoramento realizadas no PPGG-UFT em Geografia sob minha orientação; destacar as temáticas das pesquisas apresentadas nas dissertações; indicar as áreas de abrangência geográfica das pesquisas e indicar a importância das pesquisas no âmbito profissional, pessoal e acadêmico. Trata-se de um estudo narrativo, do qual fizemos opção pelo uso da pesquisa bibliográfica, consultando as dissertações descritas no texto. Este estudo permitiu um retorno às temáticas defendidas num passado próximo, cujos temas são e permanecem contemporâneos, e também possibilitou olhar as temáticas defendidas recentemente que continuam atuais.