bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human-centered visualization technologies for patient monitoring are the future: a narrative review
Authors: Gasciauskaite Greta , Lunkiewicz Justyna , Roche Tadzio R. , Spahn Donat R. , Nöthiger Christoph B. , Tscholl David W. 
Published: June 2023

AbstractMedical technology innovation has improved patient monitoring in perioperative and intensive care medicine and continuous improvement in the technology is now a central focus in this field. Because data density increases with the number of parameters captured by patient-monitoring devices, its interpretation has become more challenging. Therefore, it is necessary to support clinicians in managing information overload while improving their awareness and understanding about the patient’s health status. Patient monitoring has almost exclusively operated on the single-sensor–single-indicator principle—a technology-centered way of presenting data in which specific parameters are measured and displayed individually as separate numbers and waves. An alternative is user-centered medical visualization technology, which integrates multiple pieces of information (e.g., vital signs), derived from multiple sensors into a single indicator—an avatar-based visualization—that is a meaningful representation of the real-world situation. Data are presented as changing shapes, colors, and animation frequencies, which can be perceived, integrated, and interpreted much more efficiently than other formats (e.g., numbers). The beneficial effects of these technologies have been confirmed in computer-based simulation studies; visualization technologies improved clinicians’ situation awareness by helping them effectively perceive and verbalize the underlying medical issue, while improving diagnostic confidence and reducing workload. This review presents an overview of the scientific results and the evidence for the validity of these technologies.
Noninvasive imaging signatures of HER2 and HR using ADC in invasive breast cancer: repeatability, reproducibility, and association with pathological complete response to neoadjuvant chemotherapy
Authors: Teng Xinzhi , Zhang Jiang , Zhang Xinyu , Fan Xinyu , Zhou Ta , Huang Yu-hua , Wang Lu , Lee Elaine Yuen Phin , Yang Ruijie , Cai Jing 
Published: June 2023

Abstract
Background
The immunohistochemical test (IHC) of HER2 and HR can provide prognostic information and treatment guidance for invasive breast cancer patients. We aimed to develop noninvasive image signatures ISHER2 and ISHR of HER2 and HR, respectively. We independently evaluate their repeatability, reproducibility, and association with pathological complete response (pCR) to neoadjuvant chemotherapy.

Methods
Pre-treatment DWI, IHC receptor status HER2/HR, and pCR to neoadjuvant chemotherapy of 222 patients from the multi-institutional ACRIN 6698 trial were retrospectively collected. They were pre-separated for development, independent validation, and test–retest. 1316 image features were extracted from DWI-derived ADC maps within manual tumor segmentations. ISHER2 and ISHR were developed by RIDGE logistic regression using non-redundant and test–retest reproducible features relevant to IHC receptor status. We evaluated their association with pCR using area under receiver operating curve (AUC) and odds ratio (OR) after binarization. Their reproducibility was further evaluated using the test–retest set with intra-class coefficient of correlation (ICC).

Results
A 5-feature ISHER2 targeting HER2 was developed (AUC = 0.70, 95% CI 0.59 to 0.82) and validated (AUC = 0.72, 95% CI 0.58 to 0.86) with high perturbation repeatability (ICC = 0.92) and test–retest reproducibility (ICC = 0.83). ISHR was developed using 5 features with higher association with HR during development (AUC = 0.75, 95% CI 0.66 to 0.84) and validation (AUC = 0.74, 95% CI 0.61 to 0.86) and similar repeatability (ICC = 0.91) and reproducibility (ICC = 0.82). Both image signatures showed significant associations with pCR with AUC of 0.65 (95% CI 0.50 to 0.80) for ISHER2 and 0.64 (95% CI 0.50 to 0.78) for ISHER2 in the validation cohort. Patients with high ISHER2 were more likely to achieve pCR to neoadjuvant chemotherapy with validation OR of 4.73 (95% CI 1.64 to 13.65, P value = 0.006). Low ISHR patients had higher pCR with OR = 0.29 (95% CI 0.10 to 0.81, P value = 0.021). Molecular subtypes derived from the image signatures showed comparable pCR prediction values to IHC-based molecular subtypes (P value > 0.05).

Conclusion
Robust ADC-based image signatures were developed and validated for noninvasive evaluation of IHC receptors HER2 and HR. We also confirmed their value in predicting treatment response to neoadjuvant chemotherapy. Further evaluations in treatment guidance are warranted to fully validate their potential as IHC surrogates.
Primary breast lymphoma: a case series and review of the literature
Authors: Sakhri S. , Aloui M. , Bouhani M. , Bouaziz H. , Kamoun S. , Slimene M. , Ben Dhieb T. 
Published: June 2023

Abstract
Background
Primary breast lymphoma (PBL) is a very rare form of non-Hodgkin's lymphoma (NHL), defined as a malignant primary lymphoma occurring in the breast in the absence of previously detected lymphoma localizations. Our study aims to retrospectively evaluate the epidemiological, clinical, and imaging findings and therapeutic features of breast lymphomas in patients with primary lymphoma of the breast.

Materials and methods
This is a retrospective study including 13 patients with primary non-Hodgkin's lymphoma of the breast treated at the Salah Azaiez Institute of Oncology from 2000 to 2019. This sample includes 1 case of follicular lymphoma, 2 cases of large T-cell lymphoma, and 10 cases of large B-cell lymphoma.

Results
Patients included in the study were aged between 17 and 89 years (average age of 52.6 years). All patients were referred because of a lump in the breast, and only one patient consulted with inflammatory signs in the breast. The average clinical size of the tumor was 7.2 cm, with a maximum of 15 cm. Mammography showed an oval mass with circumscribed margins in the majority of cases. Ultrasound showed in most cases a hypoechoic irregular mass or multilobulated mass with irregular margins and hypervascular on color Doppler. Magnetic resonance imaging (MRI) was performed on only three patients and showed a spiculated lesion with polycyclic limits. Eight patients underwent surgery. In our study breast lymphomas involved 10 cases of large B-cell lymphoma, one case of follicular lymphoma, and two cases of large T-cell lymphoma. In this series, 11 patients had localized stages (I + II) at diagnosis, and 2 patients had disseminated stages (stage III) of primary breast lymphoma. Seven patients underwent chemotherapy treatment alone, and five had chemotherapy with radiotherapy. The median follow-up of our patients was 53 months, ranging from 1 to 177 months. Overall survival was 71% at 3 years and 51% at 5 years.

Conclusion
Primary breast lymphoma is an uncommon type of breast malignancy. The optimal treatment modality is still in question because of the rarity of this disease. However, the use of combination therapy produces the most favorable results. Surgery is not yet recommended.
Effect of blockchain technology in innovating accountants’ skills: a multimethodology study in the industrial companies listed on the Amman Stock Exchange
Authors: Zayed Lena M. M. , Othman Othman Hussein 
Published: June 2023

AbstractThis study aimed at analyzing the effect of blockchain technology in innovating accountants’ skills as a multimethodology study in the industrial companies listed on the Amman Stock Exchange. For achieving this goal, the researchers adopted the multimethodology approach using mixed methods between quantitative and qualitative research methodologies by conducting interviews with accountants, auditors, and financial managers forming a study sample of 50 individuals. Results show that the highest remarkable indication concerning the phenomenon of analyzing the effect of Blockchain technology in innovating accountants’ skills is (Increasing performance efficiency) as an emerging theme. Then followed by (Blockchain technology will work on innovating accountants’ skills) as the second emerging theme. And then followed by (Enhancing accountants’ skills) as the third emerging theme. And these results reflect the convictions and expectations of the study sample of accountants, auditors, and financial managers that the impact of implementing blockchain technology will innovate accountants’ skills.
Learning-oriented assessment and its effects on the perceptions and argumentative writing performance of impulsive vs. reflective learners
Authors: Estaji Masoomeh , Safari Fatemeh 
Published: June 2023

AbstractLearning-oriented assessment (LOA) is becoming increasingly popular in language education. The rationale for this popularity is the belief that LOA not only provides teachers with the necessary information for regular and ongoing evaluation but also it effectively assists learners in their learning process. This study attempted to examine the effectiveness of LOA in the argumentative writing skills of reflective and impulsive EFL learners. To this end, the study explored the learners’ perceptions of LOA through a survey questionnaire. To collect data, 116 English learners at an intermediate level of proficiency participated in the study and responded to Barrat’s BIS 11 learning style questionnaire (Journal of Clinical Psychology 51:768–774, 1995). Based on their responses, the participants were divided into two groups of impulsive (N = 59) and reflective (N = 57) learners, with four missing participants. Each group was further divided into two sub-groups, in one of which pseudo-integrative argumentative writing was taught and in the other the learners were involved in learning refutation argumentative writing. Other than the type of writing, both groups were provided with regular feedback on their diagnosed writing problems and performance within 16 sessions. They were also involved in self- and peer assessment. Analysis of the results revealed that LOA significantly improved the students’ writing performance. Moreover, while the type of the writing task did not have any significant effect, the reflective learners outperformed the impulsive ones in their writing performance at the end of the treatment. The results also revealed that the leaners generally had positive perceptions about the use of the LOA approach. In particular, they acknowledged the contributions of the teacher’s feedback, peer assessment, and classroom discussion to their writing development throughout the course. However, the reflective learners showed more appreciation of the tasks when it came to developing competence and demanding critical thinking. Hence, the conclusion is that LOA can be effectively used as a learning approach to promote Iranian EFL learners’ writing performance and landscape.
The oral repellent – science fiction or common sense? Insects, vector-borne diseases, failing strategies, and a bold proposition
Authors: Bauer Irmgard L. 
Published: June 2023

AbstractOver the last decades, unimaginable amounts of money have gone into research and development of vector control measures, repellents, treatment, and vaccines for vector borne diseases. Technological progress and scientific breakthroughs allowed for ever more sophisticated and futuristic strategies. Yet, each year, millions of people still die or suffer from potentially serious consequences of malaria or dengue to more recent infections, such as zika or chikungunya, or of debilitating consequences of neglected tropical diseases. This does not seem value for money. In addition, all current vector control strategies and personal protection methods have shortcomings, some serious, that are either destructive to non-target species or unsatisfactory in their effectiveness. On the other hand, the rapid decline in insect populations and their predators reflects decades-long aggressive and indiscriminate vector control. This major disruption of biodiversity has an impact on human life not anticipated by the well-meaning killing of invertebrates. The objective of this paper is to re-examine current control methods, their effectiveness, their impact on biodiversity, human and animal health, and to call for scientific courage in the pursuit of fresh ideas. This paper brings together topics that are usually presented in isolation, thereby missing important links that offer potential solutions to long-standing problems in global health. First, it serves as a reminder of the importance of insects to human life and discusses the few that play a role in transmitting disease. Next, it examines critically the many currently employed vector control strategies and personal protection methods. Finally, based on new insights into insect chemo-sensation and attractants, this perspective makes a case for revisiting a previously abandoned idea, the oral repellent, and its use via currently successful methods of mass-application. The call is out for focused research to provide a powerful tool for public health, tropical medicine, and travel medicine.
Vibrating toothbrush, ice, or topical anesthetic agent to reduce pain of local anesthetic injection in 5- to 12-year-old children undergoing dental procedures — a randomized controlled trial
Authors: Mittal Meenu , Kumar Ashok , Chopra Radhika , Kaur Gurvinder , Sharma Sarang 
Published: June 2023

Abstract

Background
Application of topical anesthetic agent prior to injection is the most commonly used method to control initial needle penetration pain of local anesthetic injection. Ice and vibration stimulus application are other nonpharmacologic methods used to reduce painful sensations of injection. The present study aims to verify and compare topical anesthetic, ice pretreatment, and electric toothbrush as a vibratory device, to reduce the pain of local anesthetic injections.
The study was conducted on children aged 5–12 years, requiring extraction of a maxillary primary tooth. A randomized control trial design was used wherein each child was randomly assigned by permuted block randomization design method to receive either lignocaine 5% as topical anesthetic or ice pretreatment or motorized toothbrush as a vibratory device during local anesthetic injections. Sound, eye, and motor (SEM) scale was used for objective evaluation of pain during injection, and Faces Pain Scale (FPS) was used for subjective evaluation. For statistical analysis, nonparametric test — Kruskal Wallis/ANOVA test for three groups and between two groups Mann–Whitney U-test, was used to compare SEM and FPS values. Level of significance chosen was p < 0.05.

Results
SEM (palatal) and FPS (palatal) scores were slightly higher in topical anesthetic group as compared to ice pretreatment or vibration group, but the differences were not statistically significant. There were no statistically significant differences among SEM (buccal) and FPS (buccal) scores in all the three groups.

Conclusions
Ice cooling and electric toothbrush-induced vibration were as effective as topical anesthetic for reduction in pain due to injection.

Trial registration
The CTRI number of the trial is CTRI/2021/03/032046.
Therapeutic efficacy of voltage-gated sodium channel inhibitors in epilepsy
Authors: Agbo John , Ibrahim Zainab G. , Magaji Shehu Y. , Mutalub Yahkub Babatunde , Mshelia Philemon Paul , Mhya Daniel H. 
Published: June 2023

AbstractEpilepsy is a neurological disease characterized by excessive and abnormal hyper-synchrony of electrical discharges of the brain and a predisposition to generate epileptic seizures resulting in a broad spectrum of neurobiological insults, imposing psychological, cognitive, social and also economic burdens to the sufferer. Voltage-gated sodium channels (VGSCs) are essential for the generation and propagation of action potentials throughout the central nervous system. Dysfunction of these channels has been implicated in the pathogenesis of epilepsy. VGSC inhibitors have been demonstrated to act as anticonvulsants to suppress the abnormal neuronal firing underlying epileptic seizures, and are used for the management and treatment of both genetic-idiopathic and acquired epilepsies. We discuss the forms of idiopathic and acquired epilepsies caused by VGSC mutations and the therapeutic efficacy of VGSC blockers in idiopathic, acquired and pharmacoresistant forms of epilepsy in this review. We conclude that there is a need for better alternative therapies that can be used alone or in combination with VGSC inhibitors in the management of epilepsies. The current anti-seizure medications (ASMs) especially for pharmacoresistant epilepsies and some other types of epilepsy have not yielded expected therapeutic efficacy partly because they do not show subtype-selectivity in blocking sodium channels while also bringing side effects. Therefore, there is a need to develop novel drug cocktails with enhanced selectivity for specific VGSC isoforms, to achieve better treatment of pharmacoresistant epilepsies and other types of epileptic seizures.
Validation of Fuscoporia (Hymenochaetales, Basidiomycota) ITS sequences and five new species based on multi-marker phylogenetic and morphological analyses
Authors: Cho Yoonhee , Kim Dohye , Lee Yoongil , Jeong Juhwan , Hussain Shahid , Lim Young Woon 
Published: June 2023

AbstractAlthough there is a continuous increase in available molecular data, not all sequence identities in public databases are always properly verified and managed. Here, the sequences available in GenBank for Fuscoporia (Hymenochaetales) were validated. Many morphological characters of Fuscoporia overlap among the species, emphasizing the role of molecular identification for accuracy. The identities of 658 Fuscoporia GenBank internal transcribed spacer (ITS) sequences were assessed using ITS phylogeny, revealing 109 (16.6%) misidentified and 196 (29.8%) unspecified sequences. They were validated and re-identified based on the research articles they were published in and, if unpublished, based on sequences from the type, type locality-derived sequences, or otherwise reliable sequences. To enhance the resolution of species delimitation, a phylogenetic assessment of a multi-marker dataset (ITS + nrLSU + rpb2 + tef1) was conducted. The multi-marker phylogeny resolved five of the twelve species complexes found in the ITS phylogeny and uncovered five new Fuscoporia species: F. dolichoseta, F. gilvoides, F. koreana, F. reticulata, and F. semicephala. The validated ITS sequences in this study may prevent further accumulation of misidentified sequences in public databases and contribute to a more accurate taxonomic evaluation of Fuscoporia species.
Outcome of direct-acting antiviral treatment in patients with hepatitis C virus/hepatitis B virus coinfection
Authors: Shalaby El-Araby Mohamed Ibrahim , Abdelsameea Eman , Naguib Mary , Gomaa Asmaa , Waked Imam 
Published: June 2023

Abstract
Background
Oral direct-acting antiviral (DAA) regimens for chronic hepatitis C virus (HCV) infection have greatly improved treatment efficacy, with sustained virological response (SVR) rates of > 95% for HCV monoinfected patients. However, hepatitis B virus (HBV)/HCV coinfection is more complex than monoinfection with HBV or HCV alone. We evaluated the SVR rate at 12 weeks post-treatment with DAAs in patients with HCV/HBV and evaluated the rate of HBV reactivation during and 6 months after treatment.

Results
Among the included patients, 191 (95.5%) achieved SVR. Older age, low platelet count, high serum creatinine, and higher liver stiffness value measured by fibroscan were predictors of failure to achieve SVR. The 16 patients (8%) with HBV reactivation patients had significantly higher ALT and serum creatinine and a high HCV RNA viral load at baseline compared with that of those without HBV reactivation.

Conclusion
Patients who received DAAs to treat HCV/HBV coinfection showed a high SVR. However, it is important to be aware of the potential risk for HBV reactivation during and after treatment with DAAs.
Structural system yielding minimum differences between ordinary and staged analyses
Authors: Elansary Ahmed A. , Metwally Mohamed I. , El-Attar Adel G. 
Published: June 2023

AbstractStructural engineers should appropriately design concrete structures to resist lateral loads. Determining the adequate system for resisting the expected lateral loads is important to control the building drift. Choosing the appropriate system is usually conducted assuming the predicted forces are applied to completed concrete buildings at one step which is commonly known as ordinary analysis (OA). Nevertheless, these structures are constructed sequentially which requires using staged analysis (SA) instead of OA. In this paper, a comprehensive numerical model for SA of concrete buildings, which accounts for time dependent effects, is utilized using a well-validated commercial software. Six reinforced concrete buildings with 10 and 20 storeys are analyzed using the developed model. Three various structural systems are considered (Rigid Frame (RF), Shear Wall (SW), and Wall Frame (WF). A comparison is conducted between the displacements and internal forces in beams and slabs obtained from the SA and OA. For a 10-storeys RF building, maximum bending moment from SA is 29.9% higher than that from OA. The same conclusion was observed for the maximum shearing force with a percentage of 19.6%. Moreover, maximum bending moments and shearing forces from SA for the 20-storeys RF building are, respectively, 35.0% and 23.5% larger than those from OA. The RF and WF systems provided the minimum difference in differential displacement between the OA and SA analyses. The RF system produced the least differences in internal forces from OA and SA for all studied buildings.