bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dislocated Bilayer MOF Enables High‐Selectivity Photocatalytic Reduction of CO2 to CO
Authors: Liang Jinxia , Yu Hao , Shi Junjuan , Li Bao , Wu Lixin , Wang Ming 
Published: January 2023

AbstractThe highly selective photoreduction of CO2 into valuable small‐molecule chemical feedstocks such as CO is an effective strategy for addressing the energy crisis and environmental problems. However, it remains a challenge because the complex CO2 photoreduction process usually generates multiple possible products and requires a subsequent separation step. In this paper, 2D monolayer and bilayer porphyrin‐based metal‐organic frameworks (MOFs) are successfully constructed by adjusting the reaction temperature and solvent polarity with 5,10,15,20‐tetrakis(4‐pyridyl)porphyrin as the light‐harvesting ligand. The bilayer MOF is a low‐dimensional MOF with a special structure in which the upper and lower layers are arranged in dislocation and are bridged by halogen ions. This bilayer MOF exhibits 100% ultra‐high selectivity for the reduction of CO2 to CO under simulated sunlight without any cocatalyst or photosensitizer and can be recycled at least three times. The intrinsic mechanism of this photocatalytic CO2 reduction process is explored through experimental characterization and density functional theory (DFT) calculations. This work shows that the rational design of the number of layers in 2D MOF structures can tune the stability of these structures and opens a new avenue for the design of highly selective MOF photocatalysts.
Multi‐Wavelength Light‐Responsive Metal–Phenolic Network‐Based Microrobots for Reactive Species Scavenging
Authors: Guo Ziyi , Liu Tianyi , Gao Wanli , Iffelsberger Christian , Kong Biao , Pumera Martin 
Published: January 2023

AbstractLight‐driven microrobots with different propulsion mechanisms have attracted great attention in microrobot synthesis and applications. However, current systems rely heavily on precious metals, using a complex synthesis process and limited working wavelength. It is therefore of great interest to fabricate microrobots that can be driven by multi‐wavelength irradiation and with simple components. Here, metal–phenolic network (MPN)‐based microrobots are synthesized using a sacrificial polystyrene bead template and an extra capping is added to regulate their symmetry. The hollow MPN microrobots with different layers of capping are capable of moving under both near‐infrared (NIR) irradiation and ultraviolet (UV) irradiation, without fuel. The velocity of the microrobots under irradiation is altered by the thickness of the asymmetric capping and their motion could be manipulated remotely by switching the NIR or UV irradiation on and off. With light‐driven mobility, the reactive oxygen and nitrogen species (RONS) scavenging activity of the microrobots is significantly increased. Therefore, this proposed microrobot system provides a synthesis strategy to develop asymmetric light‐navigated microrobots for future medical treatment with tunable structure, multi‐wavelength light‐responsive mobility, and great RONS scavenging capacity.
Compatible Solution‐Processed Interface Materials for Improved Efficiency of Polymer Solar Cells
Authors: Xu Zhuo , Madalaimuthu Jose Prince , Slowik Josef Bernd , Meitzner Rico , Anand Aman , Alam Shahidul , Corte Héctor , Stumpf Steffi , Schubert Ulrich S. , Hoppe Harald 
Published: January 2023

AbstractThe electron transport layer (ETL) in an organic solar cell is one of the main components that play a crucial role in the extraction of charges, improving efficiency, and increasing the lifetime of the solar cells. Herein, solution‐processed PBDTTT‐C‐T:PC71BM‐based organic solar cells are fabricated using conjugated PDINO molecules, sol‐gel derived under stoichiometric titanium oxide (TiOx), and a mixture of the same as an ETL. For PBDTTT‐C‐T:PC71BM‐based organic solar cells, a blend of organic‐inorganic ETLs demonstrates reduced bimolecular recombination and trap‐assisted recombination than a single ETL of either two materials. Furthermore, in both, fullerene and nonfullerene systems, the efficiency of the devices employing the blend ETL as compared to the single ETLs show some performance improvement. The strategy of integrating compatible organic and inorganic interface materials to improve device efficiency and lifetime simultaneously, and demonstrate the universality of different systems, has potential significance for the commercial development of organic solar cells.
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils
Authors: Zhang Yuanyuan , Liu Tianxiao , Deng Zhiyong , Fang Wenqian , Zhang Xian , Zhang Shuya , Wang Minjie , Luo Songyuan , Meng Zhaojie , Liu Jing , Sukhova Galina K. , Li Dazhu , McKenzie Andrew N. J. , Libby Peter , Shi Guo‐Ping , Guo Junli 
Published: January 2023

AbstractDevelopment of abdominal aortic aneurysms (AAA) enhances lesion group‐2 innate lymphoid cell (ILC2) accumulation and blood IL5. ILC2 deficiency in Rorafl/flIl7rCre/+ mice or induced ILC2 depletion in Icosfl‐DTR‐fl/+Cd4Cre/+ mice expedites AAA growth, increases lesion inflammation, but leads to systemic IL5 and eosinophil (EOS) deficiency. Mechanistic studies show that ILC2 protect mice from AAA formation via IL5 and EOS. IL5 or ILC2 from wild‐type (WT) mice, but not ILC2 from Il5−/− mice induces EOS differentiation in bone‐marrow cells from Rorafl/flIl7rCre/+ mice. IL5, IL13, and EOS or ILC2 from WT mice, but not ILC2 from Il5−/− and Il13−/− mice block SMC apoptosis and promote SMC proliferation. EOS but not ILC2 from WT or Il5−/− mice block endothelial cell (EC) adhesion molecule expression, angiogenesis, dendritic cell differentiation, and Ly6Chi monocyte polarization. Reconstitution of WT EOS and ILC2 but not Il5−/− ILC2 slows AAA growth in Rorafl/flIl7rCre/+ mice by increasing systemic EOS. Besides regulating SMC pathobiology, ILC2 play an indirect role in AAA protection via the IL5 and EOS mechanism.
Encapsulation of phenylacetic acid in block copolymer nanoparticles during polymerization induced self‐assembly
Authors: Li Guanrui , Barzycki Daniel C. , Ricarte Ralm G. 
Published: January 2023

AbstractPolymerization induced self‐assembly (PISA) is an in situ method for producing block copolymer nanoparticles. Performing PISA in the presence of a pharmaceutical drug causes the nanoparticles to encapsulate the drug. While this approach is straightforward, the effects of drug loading and block copolymer composition remain unclear. Here, we investigate encapsulation of the drug phenylacetic acid (PA) in poly(glycerol monomethacrylate)‐block‐poly(2‐hydroxypropyl methacrylate) (PGMA‐PHPMA) nanoparticles during PISA. Nanoparticle morphology is characterized by electron microscopy and light scattering, while encapsulation efficiency () is quantified using nuclear magnetic resonance diffusometry. Increasing the PA loading shifts the nanoparticle morphology from spherical micelles cylindrical micelles vesicles. At a 32 mg/ml PA loading, maximizes at ~80%. Increasing the PHPMA degree of polymerization minimally impacts . The invariance of toward core block length suggests that PA binds to the nanoparticle corona, highlighting the importance of the hydrophilic block for drug encapsulation during PISA.
Clinical characteristics and outcome of 318 families with familial monoclonal gammopathy: A multicenter Intergroupe Francophone du Myélome study
Authors: Dumontet Charles , Demangel Delphine , Galia Perrine , Karlin Lionel , Roche Laurent , Fauvernier Mathieu , Golfier Camille , Laude Marie‐Charlotte , Leleu Xavier , Rodon Philippe , Roussel Murielle , Azaïs Isabelle , Doyen Chantal , Slama Borhane , Manier Salomon , Decaux Olivier , Pertesi Maroulio , Beaumont Marie , Caillot Denis , Boyle Eileen M. , Cliquennois Manuel , Cony‐Makhoul Pascale , Doncker Anne‐Violaine , Dorvaux Véronique , Petillon Marie Odile , Fontan Jean , Hivert Bénédicte , Leduc Isabelle , Leyronnas Cécile , Macro Margaret , Maigre Michel , Mariette Clara , Mineur Philippe , Rigaudeau Sophie , Royer Bruno , Vincent Laure , Mckay James , Perrial Emeline , Garderet Laurent 
Published: January 2023

AbstractFamilial forms of monoclonal gammopathy, defined as multiple myeloma (MM) or Monoclonal Gammopathy of Undetermined Significance (MGUS), are relatively infrequent and most series reported in the literature describe a limited number of families. MM rarely occurs in a familial context. MGUS is observed much more commonly, which can in some cases evolve toward full‐blown MM. Although recurrent cytogenetic abnormalities have been described in tumor cells of sporadic cases of MM, the pathogenesis of familial MM remains largely unexplained. In order to identify genetic factors predisposing to familial monoclonal gammopathy, the Intergroupe Francophone du Myélome identified 318 families with at least two confirmed cases of monoclonal gammopathy. There were 169 families with parent/child pairs and 164 families with cases in at least two siblings, compatible with an autosomal transmission. These familial cases were compared with sporadic cases who were matched for age at diagnosis, sex and immunoglobulin isotype, with 10 sporadic cases for each familial case. The gender distribution, age and immunoglobulin subtypes of familial cases were unremarkable in comparison to sporadic cases. With a median follow‐up of 7.4 years after diagnosis, the percentage of MGUS cases having evolved to MM was 3%. The median overall survival of the 148 familial MM cases was longer than that of matched sporadic cases, with projected values of 7.6 and 16.1 years in patients older and younger than 65 years, respectively. These data suggest that familial cases of monoclonal gammopathy are similar to sporadic cases in terms of clinical presentation and carry a better prognosis.
The Composite Immune Risk Score predicts overall survival after allogeneic hematopoietic stem cell transplantation: A retrospective analysis of 1838 cases
Authors: Cao Yigeng , Gong Xiaowen , Feng Yahui , Wang Mingyang , Hu Yu , Liu Huilan , Liu Xueou , Qi Saibing , Ji Yanping , Liu Fang , Zhu Huaiping , Guo Wenwen , Shen Qiujin , Zhang Rongli , Zhao Ningning , Zhai Weihua , Song Xiaoqiang , Chen Xin , Geng Liangquan , Chen Xia , Zheng Xuetong , Ma Qiaoling , Tang Baolin , Wei Jialin , Huang Yong , Ren Yuanyuan , Song Kaidi , Yang Donglin , Pang Aiming , Yao Wen , He Yi , Shang Yue , Wan Xiang , Zhang Wei , Zhang Song , Sun Guangyu , Feng Sizhou , Zhu Xiaofan , Han Mingzhe , Song Zhen , Guo Ye , Sun Zimin , Jiang Erlie , Chen Junren 
Published: January 2023

AbstractThere has been little consensus on how to quantitatively assess immune reconstitution after hematopoietic stem cell transplantation (HSCT) as part of the standard of care. We retrospectively analyzed 11 150 post‐transplant immune profiles of 1945 patients who underwent HSCT between 2012 and 2020. 1838 (94.5%) of the cases were allogeneic HSCT. Using the training set of patients (n = 729), we identified a composite immune signature (integrating neutrophil, total lymphocyte, natural killer, total T, CD4+ T, and B cell counts in the peripheral blood) during days 91–180 after allogeneic HSCT that was predictive of early mortality and moreover simplified it into a formula for a Composite Immune Risk Score. When we verified the Composite Immune Risk Score in the validation (n = 284) and test (n = 391) sets of patients, a high score value was found to be associated with hazard ratios (HR) of 3.64 (95% C.I. 1.55–8.51; p = .0014) and 2.44 (95% C.I., 1.22–4.87; p = .0087), respectively, for early mortality. In multivariate analysis, a high Composite Immune Risk Score during days 91–180 remained an independent risk factor for early mortality after allogeneic HSCT (HR, 1.80; 95% C.I., 1.28–2.55; p = .00085). In conclusion, the Composite Immune Risk Score is easy to compute and could identify the high‐risk patients of allogeneic HSCT who require targeted effort for prevention and control of infection.
Waldenström macroglobulinemia: 2023 update on diagnosis, risk stratification, and management
Authors: Gertz Morie A. 
Published: January 2023

AbstractDisease OverviewWaldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma with immunoglobulin M (IgM) monoclonal protein. Clinical features include anemia, thrombocytopenia, hepatosplenomegaly, lymphadenopathy, and rarely hyperviscosity.DiagnosisPresence of IgM monoclonal protein associated with ≥10% clonal lymphoplasmacytic cells in bone marrow confirms the diagnosis. The L265P mutation in MYD88 is detectable in more than 90% of patients and is found in most IgM MGUS patients. MYD88 is not required for the diagnosis.Risk StratificationAge, hemoglobin level, platelet count, β2 microglobulin, LDH, and monoclonal IgM concentrations are characteristics that are predictive of outcomes.Risk‐Adapted TherapyNot all patients who fulfill WM criteria require therapy; these patients can be observed until symptoms develop. Rituximab‐monotherapy is inferior to regimens that combine it with bendamustine, an alkylating agent, a proteosome inhibitor, or a BTK inhibitor. The preferred Mayo Clinic induction is either rituximab and bendamustine (without rituximab maintenance) or zanubrutinib.Management of Refractory DiseaseBortezomib, cyclophosphamide, fludarabine, thalidomide, everolimus, Bruton Tyrosine Kinase inhibitors, carfilzomib, lenalidomide, bendamustine, and venetoclax have all been shown to have activity in relapsed WM. Given WM's natural history, the reduction of therapy toxicity is an important part of treatment selection.
Clinico‐genetic and prognostic analyses of 716 patients with primary myelodysplastic syndrome and myelodysplastic syndrome/acute myeloid leukemia based on the 2022 International Consensus Classification
Authors: Lee Wan‐Hsuan , Lin Chien‐Chin , Tsai Cheng‐Hong , Tien Feng‐Ming , Lo Min‐Yen , Ni Sao‐Chih , Yao Ming , Tseng Mei‐Hsuan , Kuo Yuan‐Yeh , Liu Ming‐Chih , Tang Jih‐Luh , Sun Hsun‐I , Chuang Yi‐Kuang , Chou Wen‐Chien , Hou Hsin‐An , Tien Hwei‐Fang 
Published: January 2023

AbstractThe 2022 International Consensus Classification (ICC) recategorized myeloid neoplasms based on recent advances in the understanding of the biology of hematologic malignancies, in which myelodysplastic syndrome (MDS) with blasts of 10%–19% is classified as MDS/acute myeloid leukemia (AML), MDS with mutated SF3B1, irrespective of the number of ring sideroblasts, as MDS‐SF3B1, and those with multi‐hit TP53 mutations as MDS with mutated TP53. In the analysis of 716 patients with MDS diagnosed according to the 2016 WHO classification, we found that 75.3% of patients remained in the MDS group based on the ICC, while 24.7% of patients were reclassified to the MDS/AML group after the exclusion of 15 patients who were classified to the AML group. Patients with MDS/AML showed a distinct mutational landscape and had poorer outcomes, compared to those with MDS. In the MDS group, patients with MDS‐SF3B1 had higher frequencies of DNMT3A and TET2 mutations than those with MDS, not otherwise specified, with single lineage dysplasia or multilineage dysplasia. Patients with mutated TP53 were associated with dismal outcomes, irrespective of the blast percentage. In conclusion, this study showed that the ICC facilitates efficient segregation and risk‐stratification of MDS which can help guide the treatment choice of patients with the disease.
Outcome of limited‐stage peripheral T‐Cell lymphoma after CHOP(−like) therapy: A population based study of 239 patients from the Nordic lymphoma epidemiology group
Authors: Ludvigsen Al‐Mashhadi Ahmed , Cederleuf Henrik , Kuhr Jensen Rasmus , Holm Nielsen Torsten , Bjerregård Pedersen Martin , Bech Mortensen Thomas , Relander Thomas , Jerkeman Mats , Ortved Gang Anne , Kristensen Anne Louise , Roost Clausen Michael , de Nully Brown Peter , Tang Severinsen Marianne , Jakobsen Lasse Hjort , Ellin Fredrik , El‐Galaly Tarec Christoffer 
Published: January 2023

AbstractPeripheral T‐Cell Lymphomas (PTCLs) are rare, aggressive lymphomas with poor outcomes, but limited‐stage disease is infrequent and not well‐described. This study reports outcomes and prognostic factors in limited‐stage nodal PTCLs in a binational population‐based setting. Patients were identified from the Danish and Swedish lymphoma registries. Adults diagnosed with limited‐stage nodal PTCL (stage I‐II) and treated with CHOP(−like) therapy ±radiotherapy between 2000 and 2014 were included. Medical records were reviewed by local investigators. A total of 239 patients with a median age of 62 years were included; 67% received 6–8 cycles of CHOP(−like) therapy and 22% received 3–4 cycles, of which 59% also received radiotherapy. Autologous stem cell transplant consolidation was administered to 16% of all patients. Median follow‐up was 127 months with 5‐years overall survival (OS) of 58% (95% CI: 53–65) and progression‐free survival (PFS) of 53% (95% CI: 47–59). In multivariable analysis, age ≥ 60 years and B‐symptoms were unfavorable and ALK+ anaplastic large cell T‐Cell lymphoma was favorable for survival outcomes. There was no difference in treatment‐specific outcome (3–4 cycles vs. 6–8 cycles of CHOP(−like) ± radiotherapy). Low‐risk patients (age < 60 without B‐symptoms) had a 5‐year OS of 77% (95% CI 67–89%). In the present study of limited‐stage nodal PTCL, survival after curative intent chemotherapy +/− radiotherapy was inferior to that of limited‐stage diffuse large B‐cell lymphoma, but a subgroup of young patients without B‐symptoms had very good outcomes. Treatment outcomes after 3–4 cycles versus 6–8 cycles of CHOP(−like) therapy were comparable.
Apathy in patients with Alzheimer's disease is a cost‐driving factor
Authors: Kruse Christopher , Maier Franziska , Spottke Annika , Bach Jan‐Philipp , Bartels Claudia , Buerger Katharina , Fellgiebel Andreas , Fliessbach Klaus , Frölich Lutz , Hausner Lucrezia , Hellmich Martin , Klöppel Stefan , Klostermann Arne , Kornhuber Johannes , Laske Christoph , Peters Oliver , Priller Josef , Richter‐Schmidinger Tanja , Schneider Anja , Shah‐Hosseini Kija , Teipel Stefan , von Arnim Christine A. F. , Wiltfang Jens , van der Wurp Hendrik , Dodel Richard , Jessen Frank 
Published: January 2023

AbstractBackgroundApathy is the most frequent neuropsychiatric symptom in patients with dementia of the Alzheimer's type (DAT). We analyzed the influence of apathy on the resource use of DAT patients and their caregivers.MethodsIncluded were baseline data of 107 DAT patients from a randomized clinical trial on apathy treatment. The Resource Utilization in Dementia (RUD) instrument assessed costs over a 1‐month period prior to baseline. Cost predictors were determined via a least absolute shrinkage and selection operator (LASSO).ResultsOn average, total monthly costs were €3070, of which €2711 accounted for caregivers’ and €359 for patients’ costs. An increase of one point in the Apathy Evaluation Scale resulted in a 4.1% increase in total costs.DiscussionApathy is a significant cost driving factor for total costs in mild to moderate DAT. Effective treatment of apathy might be associated with reduced overall costs in DAT.
Direkte Visualisierung elektrochemischer pseudo‐kapazitiver pH Sprünge an einer Graphenelektrode**
Authors: Wang Yongkang , Seki Takakazu , Liu Xuan , Yu Xiaoqing , Yu Chun‐Chieh , Domke Katrin F. , Hunger Johannes , Koper Marc T. M. , Chen Yunfei , Nagata Yuki , Bonn Mischa 
Published: January 2023

AbstractMolekulare Einblicke in Wasser an Elektrodengrenzflächen sind für die Aufklärung vieler elektrochemischer Phänomene, unter Anderem der elektrokatalytischen Wasserspaltung und der kapazitiven Energiespeicherung, von wesentlicher Bedeutung, aber die spektroskopische Untersuchung dieser Grenzflächen bleibt eine Herausforderung. Mit Hilfe der oberflächenspezifischen heterodyn‐detektierten Summenfrequenzspektroskopie (HD‐SFG) haben wir direkten Zugang zum Grenzflächenwasser in Kontakt mit elektrifiziertem Graphen auf Calciumfluorid (CaF2). Wir beobachten abrupte Änderungen der HD‐SFG‐Spektren bei Veränderung des angelegten Potenzials. Die Auswertung der Spektren zeigt, dass diese Variationen nicht durch die Aufladung/Entladung von Graphen, sondern durch die Aufladung/Entladung des CaF2‐Substrats in einem pseudokapazitiven Prozess hervorgerufen werden. Überraschenderweise sind die potenzial‐abhängigen Spektren nahezu identisch mit den pH‐abhängigen Spektren, was zeigt, dass das pseudokapazitive Verhalten mit einer erheblichen lokalen pH‐Änderung verbunden ist, die durch Wasserdissoziation verursacht wird. Unsere Arbeit veranschaulicht so zum ersten Mal die molekularen Details der Pseudokapazität an der Grenzfläche zwischen Elektrode und wässrigem Elektrolyten.
Effect of nano‐sized zinc citrate on the supercritical carbon dioxide‐assisted extrusion foaming behavior of poly(lactic acid)
Authors: Zhou Gang , Liu Wenjun , Yin Haiyan , Zhang Yinhang , Huang Chengzhe 
Published: January 2023

AbstractPoly(lactic acid) (PLA) foams containing various amounts of an epoxy as a chain extender (CE) and nano‐sized zinc citrate as a nucleating agent are prepared by continuous extrusion using supercritical CO2 (sc‐CO2) as a physical foaming agent. Processing parameters such as the CE content, sc‐CO2 flow rate, and foaming temperature are optimized with regard to the apparent density and expansion ratio of the PLA foams. The nano‐sized zinc citrate exhibits a high nucleation activity for the crystallization of the PLA. The addition of 0.5 wt% nano‐sized zinc citrate significantly increases the compressive strength and modulus of the PLA foams from 0.124 MPa and 3.1 MPa to 0.35 MPa and 19 MPa, respectively. The PLA/0.5 wt% nano‐sized zinc citrate foam shows a microcellular structure with an average cell diameter of 17.1 μm.
Applications of In Situ Raman Spectroscopy on Rechargeable Batteries and Hydrogen Energy Systems
Authors: Lin Xiu‐Mei , Li Jian‐Feng 
Published: January 2023

AbstractThe rapid growth of the economy promotes the increasing demand for energy, which accelerates resource shortage and environmental pollution issues caused by fossil fuel combustion. Electrochemical energy conversion and storage (EECS) techniques such as rechargeable batteries, fuel cells, and water electrolysis have provided promising solutions for addressing these issues. However, their further electrochemical performance improvement is still challenging due to the lack of understanding of their reaction mechanisms. Therefore, in situ tracking these electrochemical processes to capture the intermediates for mechanism verification is significant. In this review, recent work on in situ Raman spectroscopy applications on EECS systems is summarized with emphasis on the intermediates capturing capability of this technique for reaction mechanism elucidation. We aim to elucidate the underlying reaction mechanism to provide guidelines for the design of high‐efficiency electrocatalysts for fuel cells and water electrolysis and the advanced electrode materials for rechargeable batteries