bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID‐19 Induces Neuroinflammation and Suppresses Peroxisomes in the Brain
Authors: Roczkowsky A. , Limonta D. , Fernandes J. P. , Branton W. G. , Clarke M. , Hlavay B. , Noyce R. S. , Joseph J. T. , Ogando N. S. , Das S. K. , Elaish M. , Arbour N. , Evans D. H. , Langdon K. , Hobman T. C. , Power C. 
Published: May 2023

ObjectivePeroxisome injury occurs in the central nervous system (CNS) during multiple virus infections that result in neurological disabilities. We investigated host neuroimmune responses and peroxisome biogenesis factors during severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection using a multiplatform strategy.MethodsBrain tissues from coronavirus disease 2019 (COVID‐19) (n = 12) and other disease control (ODC) (n = 12) patients, as well as primary human neural cells and Syrian hamsters, infected with a clinical variant of SARS‐CoV‐2, were investigated by droplet digital polymerase chain reaction (ddPCR), quantitative reverse transcriptase PCR (RT‐qPCR), and immunodetection methods.ResultsSARS‐CoV‐2 RNA was detected in the CNS of 4 patients with COVID‐19 with viral protein (NSP3 and spike) immunodetection in the brainstem. Olfactory bulb, brainstem, and cerebrum from patients with COVID‐19 showed induction of pro‐inflammatory transcripts (IL8, IL18, CXCL10, NOD2) and cytokines (GM‐CSF and IL‐18) compared to CNS tissues from ODC patients (p < 0.05). Peroxisome biogenesis factor transcripts (PEX3, PEX5L, PEX11β, and PEX14) and proteins (PEX3, PEX14, PMP70) were suppressed in the CNS of COVID‐19 compared to ODC patients (p < 0.05). SARS‐CoV‐2 infection of hamsters revealed viral RNA detection in the olfactory bulb at days 4 and 7 post‐infection while inflammatory gene expression was upregulated in the cerebrum of infected animals by day 14 post‐infection (p < 0.05). Pex3 transcript levels together with catalase and PMP70 immunoreactivity were suppressed in the cerebrum of SARS‐CoV‐2 infected animals (p < 0.05).InterpretationCOVID‐19 induced sustained neuroinflammatory responses with peroxisome biogenesis factor suppression despite limited brainstem SARS‐CoV‐2 neurotropism in humans. These observations offer insights into developing biomarkers and therapies, while also implicating persistent peroxisome dysfunction as a contributor to the neurological post‐acute sequelae of COVID‐19. ANN NEUROL 2023;94:531–546
A plea for more freshwater experts in IPBES
Authors: Kuiper Jan J. 
Published: May 2023

Abstract

Biodiversity loss occurs much faster in the world's freshwaters than in the terrestrial or marine realms, yet worries have been expressed that freshwater systems are not given the same priority as ‘land and oceans’ in global environmental governance.
The Intergovernmental Science–Policy Platform on Biodiversity and Ecosystem Services (IPBES) is mandated to provide the knowledge basis supporting international environmental agreements such as the Convention on Biological Diversity. To a large extent, the work of IPBES is dependent on voluntary contributions by independent experts from across the world.
Here, I present an overview of the various ways in which freshwater experts can contribute to IPBES, ultimately to strengthen the representation of freshwater ecosystems in global environmental governance.
Avenues to contribute include participating in the development of IPBES assessment reports that are adopted by the 139 member states, engaging in the external review process of IPBES products, filling in knowledge gaps as identified by IPBES assessment reports to inform upcoming assessments, implementing IPBES outcomes and recommendations in practice, and actively engaging with plenary meetings of government delegations to influence decisions.
Actively supporting governments worldwide in making evidence‐based decisions can be intrinsically rewarding and offers several additional benefits. These benefits include the potential for enhanced professional reputation, given the authoritative nature of IPBES products; networking and collaboration opportunities with experts and stakeholders from around the world; and professional development through gaining experience in navigating the science–policy interface on biodiversity and ecosystem services.
I conclude with a call to action.
Clinical and Biomarker Responses to BI 655064, an Antagonistic Anti‐CD40 Antibody, in Patients With Active Lupus Nephritis: A Randomized, Double‐Blind, Placebo‐Controlled, Phase II Trial
Authors: Jayne David R. , Steffgen Jürgen , Romero‐Diaz Juanita , Bajema Ingeborg , Boumpas Dimitrios T. , Noppakun Kajohnsak , Amano Hirofumi , Gomez Harold Michael , Satirapoj Bancha , Avihingsanon Yingyos , Chawanasuntorapoj Ratana , Madero Magdalena , Naumnik Beata , Recto Rhona , Fagan Nora , Revollo Ivette , Wu Jing , Visvanathan Sudha , Furie Richard 
Published: May 2023

ObjectiveTo characterize its dose‐response relationship, BI 655064 (an anti‐CD40 monoclonal antibody) was tested as an add‐on to mycophenolate and glucocorticoids in patients with active lupus nephritis (LN).MethodsA total of 121 patients were randomized (2:1:1:2) to receive placebo or BI 655064 120, 180, or 240 mg and received a weekly loading dose for 3 weeks followed by dosing every 2 weeks for the 120 and 180 mg groups, and 120 mg weekly for the 240 mg group. The primary endpoint was complete renal response (CRR) at week 52. Secondary endpoints included CRR at week 26.ResultsA dose‐response relationship with CRR at week 52 was not shown (BI 655064 120 mg, 38.3%; 180 mg, 45.0%; 240 mg, 44.6%; placebo, 48.3%). At week 26, 28.6% (120 mg), 50.0% (180 mg), 35.0% (240 mg), and 37.5% (placebo) achieved CRR. The unexpected high placebo response prompted a post hoc analysis evaluating confirmed CRR (cCRR, at weeks 46 and 52). cCRR was achieved in 22.5% (120 mg), 44.3% (180 mg), 38.2% (240 mg), and 29.1% (placebo) of patients. Most patients reported ≥1 adverse event (BI 655064, 85.7–95.0%; placebo, 97.5%), most frequently infections and infestations (BI 655064 61.9–75.0%; placebo 60%). Compared with other groups, higher rates of serious (20% vs. 7.5–10%) and severe infections (10% vs. 4.8–5.0%) were reported with 240 mg BI 655064.ConclusionThe trial failed to demonstrate a dose‐response relationship for the primary CRR endpoint. Post hoc analyses suggest a potential benefit of BI 655064 180 mg in patients with active LN.
Refining Incidence and Characteristics of Inflammatory Myopathies: A Quadruple‐Source Capture–Recapture Survey Using the 2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria
Authors: Debrut Léa , Giannini Margherita , Klein Delphine , Spielmann Lionel , Mertz Philippe , Martin Thierry , Nadaj‐Pakleza Aleksandra , Hirschi Sandrine , Nespola Benoit , Lannes Béatrice , Terzic Joëlle , Hinschberger Olivier , Dervieux Benjamin , Lipsker Dan , Arnaud Laurent , Gottenberg Jacques‐Eric , Kleinmann Jean François , Geny Bernard , Séverac François , Velten Michel , Sibilia Jean , Meyer Alain 
Published: May 2023

ObjectiveInflammatory myopathies (IM), characterized by muscle inflammation and weakness, are rare systemic diseases. Our previous study estimated an IM incidence rate of 7.98 cases per million people per year (95% confidence interval 7.38–8.66) and highlighted important variations that were likely because of methodologic issues rather than true epidemiologic differences. In this study, we aimed to refine the incidence of IM, using the 2017 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for IM and a quadruple‐source capture–recapture method during a 6‐year period in Alsace, France, a region with a population of 2 million having benefits of good access to health care and accredited IM referral centers.MethodsClinical data of potential IM patients were obtained from 4 sources (general practitioners and community specialists, public and private hospital records, public and private laboratories, and archives from the pathology department). Patients residing in Alsace and who fulfilled the 2017 EULAR/ACR criteria for IM between January 1, 2006, and January 1, 2013, were included. We corrected potentially incomplete ascertainment of cases with capture–recapture analyses. We studied both spatial and temporal distributions of incidence of IM. We also assessed systemic manifestations of the disease.ResultsOur review of 1,742 potential cases identified 106 patients with IM. No spatial or temporal heterogeneity was observed. Use of log‐linear models showed an estimated 14.9 additional missed cases. Thus, the incidence rate of IM was 8.22 new cases per million inhabitants per year (95% confidence interval 6.76–9.69). Extramuscular manifestations other than dermatomyositis rash were frequently recorded.ConclusionThe stringent methodology used in our study provides an accurate estimation of the incidence of IM. This study also demonstrates, in a population‐based cohort, the systemic nature of IM.image
Transition from linear to circular economy of electrical and electronic equipment: A review
Authors: Leitão Fabrício Oliveira , de Sousa Martins Thalisson , Guarnieri Patrícia , Ouro‐Salim Omar 
Published: May 2023

AbstractDue to the increasing scarcity of resources and the exponential production of electrical and electronic equipment (EEE), the transition from a linear economy (LE) to a circular economy (CE) has become crucial. This study aims to analyze the practices adopted by EEE companies in Brazil based on the ReSOLVE framework, from the perspective of transitioning to a CE. The study uses a qualitative approach, applying Integrative Literature Review (ILR) and document analysis techniques. The main findings reveal 14 practices related to CE from ILR and 11 from document analysis, suggesting that a transition from LE to CE in the EEE production chain is possible. The ReSOLVE framework can provide EEE manufacturers with opportunities to create and deliver value by improving reduction, reuse, repair, refurbishment, and recycling activities. Additionally, it can help extend their circular offerings through product‐service‐systems, optimizing value capture from a one‐time sale of EEE products to regular revenue streams, while reducing costs associated with raw materials, energy inputs, and waste management. Overall, this study contributes to advancing CE actions within the EEE sector and highlights their potential for transferability to other economic sectors.
Ceramic anterior veneer restorations in periodontally compromised patients: A retrospective study
Authors: Gaß Johanna A. , Büsch Christopher , Körner Gerd A. , Bäumer Amelie M. 
Published: May 2023

AbstractBackgroundSuccessful periodontal therapy can lead to poor esthetic results, especially in the anterior region, for which there are treatment options such as direct composite or indirect veneer restorations. Until now, there are no data describing the long‐term results of veneer restorations in periodontally treated patients. The aim of this retrospective study was to evaluate the outcome of anterior porcelain veneer restorations in periodontally compromised and noncompromised patients.MethodsPeriodontally healthy and periodontally compromised patients, who had received anterior veneer restorations at least 5 years ago, were invited to a follow‐up examination. Groups were divided according to their periodontal diagnosis (periodontally healthy, stage I/II, stage III/IV). Tooth loss, veneer loss, biologic parameters, and complication rates were examined. Also, veneers were evaluated according to modified United States Public Health Service criteria.ResultsA total of 68 patients with 312 veneers were examined with a mean follow‐up time of 8 years. Veneered teeth in patients with periodontitis stage III/IV showed no difference regarding tooth‐specific, overall, and functional veneer survival when compared to periodontally healthy patients (Kaplan–Meier analyses). In Cox regression analysis, follow‐up time had an impact on complications and veneer loss, whereas periodontal diagnosis showed no significant influence on the survival of restorations. Comparative tests showed that patients with severe periodontitis at baseline have slightly lower veneer survival rates after 8 years and slightly higher complication rates after 13 years.ConclusionLong‐term results and complication rates of veneer restorations in periodontally compromised patients are comparable to periodontally healthy patients over a mean follow‐up of 8 years.
Virtual emotional gestures to assist in the examination of the mental health of the deaf‐mutes
Authors: Liang Hui , Xu Haoming , Wang Yi , Pan Junjun , Fu Jialin , Pang Xiangwen 
Published: May 2023

AbstractThe particular characteristics of deaf‐mutes make them more likely to have mental health problems. Due to their particular way of communication, it is more difficult for them to deal with mental health problems than ordinary people. Nowadays, those psychologists who are good at sign language are in short supply, and remote assistance cannot achieve satisfactory results. Therefore, a library of virtual emotional gestures based on electroencephalogram (EEG) was established and a prototype system for mental health examination of deaf‐mutes was proposed, which help deaf‐mutes identify their psychological problems in time and assist medical staff to examine the psychological problems encountered by deaf‐mutes. In addition, the virtual library of emotional gestures is established with the assistance of the chief physician from a 3A hospital in Henan Province. More importantly, the later experiments demonstrate the applicability of this virtual system.
A case of Pierre Robin syndrome in a child with no soft palate and complications from pneumonia in Bangladesh
Authors: Amin Mohammad Ashraful , Shawon Taraque Ahamed , Shaon Naushad Khan , Nahin Sabrina , Fardous Jannatul , Hawlader Mohammad Delwer Hossain 
Published: May 2023

Key Clinical MessageChildren with Pierre Robin syndrome (PRS) often have trouble breathing and eating as soon as they are born. If conservative therapy fails to alleviate airway obstruction, surgical surgery may be considered. Patients with PRS require multidisciplinary approaches for treatment.AbstractPierre Robin syndrome is a common craniofacial abnormality that causes glossoptosis and blockage of the upper airway. This renders it difficult to feed, which leads to severe malnutrition. This condition is also often marked by an absence of a soft palate. We mention a newborn with Pierre Robin syndrome with the absence of a soft palate and pneumonia complications, whose impending respiratory failure was treated successfully. To solve the complex problems that these babies and their families are facing, a multidisciplinary approach is needed.
Spin Crossover and Fluorine‐Specific Interactions in Metal Complexes of Terpyridines with Polyfluorocarbon Tails
Authors: Nößler Maite , Neuman Nicolás I. , Böser Lisa , Jäger René , Singha Hazari Arijit , Hunger David , Pan Yixian , Lücke Clemens , Bens Tobias , van Slageren Joris , Sarkar Biprajit 
Published: May 2023

AbstractIn coordination chemistry and materials science, terpyridine ligands are of great interest, due to their ability to form stable complexes with a broad range of transition metal ions. We report three terpyridine ligands containing different perfluorocarbon (PFC) tails on the backbone and the corresponding FeII and CoII complexes. The CoII complexes display spin crossover close to ambient temperature, and the nature of this spin transition is influenced by the length of the PFC tail on the ligand backbone. The electrochemical properties of the metal complexes were investigated with cyclic voltammetry revealing one oxidation and several reduction processes. The fluorine‐specific interactions were investigated by EPR measurements. Analysis of the EPR spectra of the complexes as microcrystalline powders and in solution reveals exchange‐narrowed spectra without resolved hyperfine splittings arising from the 59Co nucleus; this suggests complex aggregation in solution mediated by interactions of the PFC tails. Interestingly, addition of perfluoro‐octanol in different ratios to the acetonitrile solution of the sample resulted in the disruption of the F
F interactions of the tails. To the best of our knowledge, this is the first investigation of fluorine‐specific interactions in metal complexes through EPR spectroscopy, as exemplified by exchange narrowing.
RNA Imaging in Live Cells†
Authors: Zhao Jingfang , Xiang Limin 
Published: May 2023

AbstractTraditional molecular biology tools have elucidated the identities and functions of RNA molecules, which are essential to the understanding of gene transcription and protein translation. Deepening this research field would further require the direct visualization of RNA dynamics such as the DNA‐RNA interactions and RNA‐protein interactions. Towards this goal, the rise of RNA imaging tools over the past 15 years has reformed how we looked at these processes. In this Emerging Topic, we first highlighted recent advances on three main RNA imaging tools based on the species of interacting molecules: RNA‐RNA pairing, RNA‐protein binding, and small molecule‐RNA complex. We introduced the advantages of these tools from a technical viewpoint, including binding affinity, fluorescent turn‐on ratio, stability, and impacts on targeted RNA. Next, we discussed new rising opportunities and future directions, echoing the state‐of‐the‐art imaging tools in the fields of fluorescent proteins and small fluorescent molecules. Together, we believe this emerging field will bring new insights on how we study RNA biology in living systems.
Synthesis of Cu‐Doped Layered Transition Metal Oxide Cathode Materials Directly from Metal‐Organic Frameworks for Sodium‐Ion Batteries
Authors: Hou Xiaoniu , Li Changfeng , Li Mengjie , Liu Yuansheng , Zhu Wei , Li Zhenfei , Xu Yunhua 
Published: May 2023

Comprehensive SummaryMn‐based layered transition metal oxides are promising cathode materials for sodium‐ion batteries (SIBs) because of their high theoretical capacities, abundant raw materials, and environment‐friendly advantages. However, they often show insufficient performance due to intrinsic issues including poor structural stability and dissolution of Mn3+. Atomic doping is an effective way to address these structural degradation issues. Herein, we reported a new synthesis strategy of a Cu‐doped layered cathode by directly calcinating a pure metal‐organic framework. Benefiting from the unique structure of MOF with atomic‐level Cu doping, a homogeneous Cu‐doped layered compound P2‐Na0.674Cu0.01Mn0.99O2 was obtained. The Cu substitution promotes the crystal structural stability and suppresses the dissolution of Mn, thus preventing the structure degradation of the layered cathode materials. A remarkably enhanced cyclability is realized for the Cu‐doped cathode compared with that without Cu doping, with 83.8% capacity retention after 300 cycles at 100 mA·g–1. Our findings provide new insights into the design of atomic‐level doping layered cathode materials constructed by MOFs for high‐performance SIBs.
Percutaneous closure of ventricular septal rupture after myocardial infarction: A retrospective study of 81 cases
Authors: Chen Tongfeng , Liu Yuhao , Zhang Jing , Sun Zirui , Han Yu , Gao Chuanyu 
Published: May 2023

AbstractObjectiveTo investigate the efficacy and safety of percutaneous closure of ventricular septal rupture (VSR) after acute myocardial infarction (AMI).MethodsThis retrospective study included 81 patients who underwent transcatheter closure for postinfarction VSR. We analyzed clinical data from hospitalization and the 30‐day follow‐up, compared clinical data from the survival and death groups, and explored the best closure time and the safety and efficacy of occlusion. The risk factors for death at 30 days were analyzed by logistic regression.ResultsC‐reactive protein (CRP), white blood cell counts, N‐terminal pro brain natriuretic peptide (NT‐ProBNP), and aspartate aminotransferase were higher in the death group than in the survival group (p < .01), with a higher rate of application of vasoactive drugs, and a shorter time from AMI to operation (p < .05). At 30 days postocclusion, 19 patients (23.5%) had died. The mortality rate was significantly lower for operation performed 3 weeks after AMI than for operation performed within 3 weeks of AMI (12.5% vs. 48%, p < .001). Devices were successfully implanted in 76 patients, with 16 (21.1%) operation‐related complications and 12 (15.8%) valve injuries. Cardiac function improved significantly (p < .001) at discharge (N = 66) and 30 days after procedure (N = 62). Qp/Qs and pulmonary artery systolic pressure decreased significantly, while aortic systolic pressure increased significantly (p < .001). Additionally, EF and LVDd improved (p < .05) after occlusion. Increases in CRP and NT‐ProBNP were risk factors for death at 30 days after closure (p < .05).ConclusionPercutaneous VSR closure can be a valuable treatment option for suitable patients with VSR.
A novel clustering model via optimized fuzzy C‐means algorithm and sandpiper optimization with cycle crossover process in IoT
Authors: Gorikapudi Sateesh , Kondaveeti Hari Kishan 
Published: May 2023

SummaryThe Internet of Things (IoT) is a paradigm change in networking that aspires to connect almost everything on the globe. Clustering methods have been presented in the context of wireless sensor networks, and their application to the IoT could solve similar problems. However, existing clustering protocols have issues with the clustering structure that affect their performance, and some approaches pose a risk of privacy leakage during the data handling process. Therefore, this article aims to establish a novel secure and energy‐aware clustering model in the IoT, in which cluster head selection is performed via a proposed sandpiper optimization with cycle crossover process (SOCCP) model. Moreover, this cluster head selection includes certain constraints, including distance, energy, security, and cluster radius, respectively. The clustering is done by the optimized fuzzy C‐means algorithm. Here, the determination of the cluster head and cluster radius is tuned optimally via an adopted SOCCP model. Final results of the employed technique are calculated using a variety of metrics, such as alive node analysis, risk analysis, distance analysis, cluster radius analysis, as well as normalized energy analysis, respectively.
New Nabokoite‐like Phases ACu7TeO4(SO4)5Cl (A=Na, K, Rb, Cs) with Decorated and Distorted Square Kagome Lattices
Authors: Murtazoev Alisher F. , Lyssenko Konstantin A. , Markina Maria M. , Dolgikh Valery A. , Vasiliev Alexander N. , Berdonosov Peter S. 
Published: May 2023

AbstractA new family of compounds ACu7TeO4(SO4)5Cl (A=Na, K, Rb, Cs) isostructural to mineral Nabokoite (K species) was synthesized by solid state and gas transport reactions in sealed ampoules and characterized in measurements of magnetization and specific heat in a wide temperature range. These complex compounds are of the utmost interest as a testing playground to study the properties of quasi‐two‐dimensional magnets with a square kagome lattice geometry. A quantum ground state of such a corner‐sharing network is a spin liquid. Unlike idealized grid analyzed in numerous models, the square kagome lattice in nabokoites is wavy and distorted being composed of versatile triangles. Moreover, it contains “excessive” decorating magnetic ions, which makes magnetism of these objects even more complicated. The interaction of these decorating ions through virtual excitations of the square kagome lattice is accompanied by the formation of a long‐range magnetic order coexisting with the spin liquid.