bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epigenetic perspectives associated with COVID-19 infection and related cytokine storm: an updated review
Authors: Dey Amit , Vaishak K. , Deka Dikshita , Radhakrishnan Arun Kumar , Paul Sujay , Shanmugam Priyadarshini , Daniel Alice Peace , Pathak Surajit , Duttaroy Asim K. , Banerjee Antara 
Published: March 2023

Abstract
Purpose
The COVID-19 pandemic caused by the novel Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has put the world in a medical crisis for the past three years; nearly 6.3 million lives have been diminished due to the virus outbreak. This review aims to update the recent findings on COVID-19 infections from an epigenetic scenario and develop future perspectives of epi-drugs to treat the disease.

Methods
Original research articles and review studies related to COVID-19 were searched and analyzed from the Google Scholar/PubMed/Medline databases mainly between 2019 and 2022 to brief the recent work.

Results
Numerous in-depth studies of the mechanisms used by SARS-CoV-2 have been going on to minimize the consequences of the viral outburst. Angiotensin-Converting Enzyme 2 receptors and Transmembrane serine protease 2 facilitate viral entry to the host cells. Upon internalization, it uses the host machinery to replicate viral copies and alter the downstream regulation of the normal cells, causing infection-related morbidities and mortalities. In addition, several epigenetic regulations such as DNA methylation, acetylation, histone modifications, microRNA, and other factors (age, sex, etc.) are responsible for the regulations of viral entry, its immune evasion, and cytokine responses also play a major modulatory role in COVID-19 severity, which has been discussed in detail in this review.

Conclusion
Findings of epigenetic regulation of viral pathogenicity open a new window for epi-drugs as a possible therapeutical approach against COVID-19.
KNN Data Filling Algorithm for Incomplete Interval-Valued Fuzzy Soft Sets
Authors: Ma Xiuqin , Han Yanyan , Qin Hongwu , Wang Peng 
Published: March 2023

AbstractAs a generalization of the fuzzy soft set, interval-valued fuzzy soft set is viewed as a more resilient and powerful tool for dealing with uncertain information. However, the lower or upper membership degree, or both of them, may be missed during the data collection and transmission procedure, which could present challenges for data processing. The existing data filling algorithm for the incomplete interval-valued fuzzy soft sets has low accuracy and the high error rate which leads to wrong filling results and involves subjectivity due to setting the threshold. Therefore, to solve these problems, we propose a KNN data filling algorithm for the incomplete interval-valued fuzzy soft sets. An attribute-based combining rule is first designed to determine whether the data involving incomplete membership degree should be ignored or filled which avoids subjectivity. The incomplete data will be filled according to their K complete nearest neighbors. To verify the validity and feasibility of the method, we conduct the randomized experiments on the real dataset as Shanghai Five-Four Hotel Data set and simulated datasets. The experimental results illustrate that our proposed method outperform the existing method on the average accuracy rate and error rate.
Influence of Sedimentary Environment Evolution on Fingerprint Characteristics of Methane Isotopes: A Case Study From Hangzhou Bay
Authors: Jiang Wenqin , Cao Ke , Duan Xiaoyong , He Xingliang , Yin Ping , Chen Junbing , Xie Yongqing , Liu Jun , Cao Binhua , Yu Xinyang , Dong Hailiang , Hou Weiguo 
Published: March 2023

AbstractTo better understand the depositional constraints on the fingerprint characteristics of methane isotopes, we present a set of carbon/hydrogen isotopic data for CH4, CO2, pore water, carbonate, and total organic carbon along a 70‐m sedimentary core. The sedimentary facies (Units I, II, and III from upper to bottom) suggested depositional environments of the present estuary, shallow marine, and floodplain‐estuary. Calculations suggested that around 86% of methane was produced through the CO2 reduction pathway. In this pathway, the hydrogen in CH4 is from ambient water, while the carbon is from dissolved inorganic carbon. Correspondingly, our study showed that the values of δDCH4 displayed similar trends with those of δDH2O and Cl− concentrations along the depth profiles. The low δDCH4 below 44.5 m corresponded to low δDH2O and low salinity during the cold and low‐sea‐level period. The values of δ13CCH4 generally synchronously changed with those of δ13CCO2. The variation trends of δ13CCH4 and δ13CCO2 were the same with δ13Ccarbonate from 10 to 70 m depth but decoupled above 10 m. The values of δ13CCH4 in Units II and III were correlated with the δ13Ccarbonates, which is related to the sedimentary processes. But decoupling of low values of δ13CCH4 and δ13CCO2 from δ13Ccarbonates in Unit I may be related to preferential microbial consumption of labile compounds with light carbon isotopic compositions, such as lipids. In short, the variations of δ13CCH4 and δDCH4 were largely related to the sedimentary process, which controlled the isotopic compositions of both water and carbonate.
Computational optimization of delivery parameters to guide the development of targeted Nasal spray
Authors: Du Jinze , Shao Xiecheng , Bouteiller Jean-Marie C. , Lu Angela , Asante Isaac , Louie Stan , Humayun Mark S. , Lazzi Gianluca 
Published: March 2023

AbstractAirborne transmission by droplets and aerosols is known to play a critical role in the spread of many viruses amongst which are the common flu and the more recent SARS-CoV-2 viruses. In the case of SARS-CoV-2, the nasal cavity not only constitutes an important viral entry point, but also a primary site of infection (Sungnak W. et al. Nat. Med. 26:681–687. https://doi.org/10.1038/s41591-020-0868-6, 2020).. Although face masks are a well-established preventive measure, development of novel and easy-to-use prophylactic measures would be highly beneficial in fighting viral spread and the subsequent emergence of variants of concern (Tao K. et al. Nat Rev Genet 22:757–773. https://doi.org/10.1038/s41576-021-00408-x, 2021). Our group has been working on optimizing a nasal spray delivery system that deposits particles inside the susceptible regions of the nasal cavity to act as a mechanical barrier to impede viral entry. Here, we identify computationally the delivery parameters that maximize the protection offered by this barrier. We introduce the computational approach and quantify the protection rate obtained as a function of a broad range of delivery parameters. We also introduce a modified design and demonstrate that it significantly improves deposition, thus constituting a viable approach to protect against nasal infection of airborne viruses. We then discuss our findings and the implications of this novel system on the prevention of respiratory diseases and targeted drug delivery.
Virus-free transfection, transient expression, and purification of human cardiac myosin in mammalian muscle cells for biochemical and biophysical assays
Authors: Velayuthan Lok Priya , Moretto Luisa , Tågerud Sven , Ušaj Marko , Månsson Alf 
Published: March 2023

AbstractMyosin expression and purification is important for mechanistic insights into normal function and mutation induced changes. The latter is particularly important for striated muscle myosin II where mutations cause several debilitating diseases. However, the heavy chain of this myosin is challenging to express and the standard protocol, using C2C12 cells, relies on viral infection. This is time and work intensive and associated with infrastructural demands and biological hazards, limiting widespread use and hampering fast generation of a wide range of mutations. We here develop a virus-free method to overcome these challenges. We use this system to transfect C2C12 cells with the motor domain of the human cardiac myosin heavy chain. After optimizing cell transfection, cultivation and harvesting conditions, we functionally characterized the expressed protein, co-purified with murine essential and regulatory light chains. The gliding velocity (1.5–1.7 µm/s; 25 °C) in the in vitro motility assay as well as maximum actin activated catalytic activity (kcat; 8–9 s−1) and actin concentration for half maximal activity (KATPase; 70–80 µM) were similar to those found previously using virus based infection. The results should allow new types of studies, e.g., screening of a wide range of mutations to be selected for further characterization.
Hybrid artificial electric field employing cuckoo search algorithm with refraction learning for engineering optimization problems
Authors: Adegboye Oluwatayomi Rereloluwa , Deniz Ülker Ezgi 
Published: March 2023

AbstractDue to its low dependency on the control parameters and straightforward operations, the Artificial Electric Field Algorithm (AEFA) has drawn much interest; yet, it still has slow convergence and low solution precision. In this research, a hybrid Artificial Electric Field Employing Cuckoo Search Algorithm with Refraction Learning (AEFA-CSR) is suggested as a better version of the AEFA to address the aforementioned issues. The Cuckoo Search (CS) method is added to the algorithm to boost convergence and diversity which may improve global exploration. Refraction learning (RL) is utilized to enhance the lead agent which can help it to advance toward the global optimum and improve local exploitation potential with each iteration. Tests are run on 20 benchmark functions to gauge the proposed algorithm's efficiency. In order to compare it with the other well-studied metaheuristic algorithms, Wilcoxon rank-sum tests and Friedman tests with 5% significance level are used. In order to evaluate the algorithm’s efficiency and usability, some significant tests are carried out. As a result, the overall effectiveness of the algorithm with different dimensions and populations varied between 61.53 and 90.0% by overcoming all the compared algorithms. Regarding the promising results, a set of engineering problems are investigated for a further validation of our methodology. The results proved that AEFA-CSR is a solid optimizer with its satisfactory performance.
Effect of chemicals on the phase and viscosity behavior of water in oil emulsions
Authors: Shafiei Masoud , Kazemzadeh Yousef , Martyushev Dmitriy A. , Dai Zhenxue , Riazi Masoud 
Published: March 2023

AbstractDue to population growth, the need for energy, especially fossil fuels, is increased every year. Since the costs of exploring new reservoirs and drilling new wells are very high, most reservoirs have passed their first and second periods of life, and it is necessary to use EOR methods. Water-based enhanced oil recovery (EOR) methods are one of the popular methods in this field. In this method, due to the possibility of emulsion formation is high, and by creating a stable emulsion, viscosity and mobility improved. In this study, the parameters affecting the stability and viscosity of the emulsion have been investigated step by step. In the first step, 50% (v/v) of water has been selected as the best water cut. The type of salt and its best concentration was evaluated in the second step by measuring the average droplets size. The third step investigated the effect of SiO2 nanoparticles and surfactant (span80) on emulsion stability and viscosity. According to the results, the best amount of water cut was 50% due to the maximum viscosity. In salts the yield was as follows: MgCl2 > CaCl2 > MgSO4 > Na2SO4 > NaCl. The best yield was related to MgCl2 at a concentration of 10,000 ppm. Finally, it was shown that the synergy of nanoparticles and surfactants resulted in higher stability and viscosity than in the case where each was used alone. It should be noted that the optimal concentration of nanoparticles is equal to 0.1% (w/w), and the optimal concentration of surfactant is equal to 200 ppm. In general, a stable state was obtained in 50% water-cut with MgCl2 salt at a concentration of 10,000 ppm and in the presence of SiO2 nanoparticles at a concentration of 0.1% and span 80 surfactants at a concentration of 200 ppm. The results obtained from this study provide important insights for optimal selection of the water-based EOR operation parameters. Viscosity showed a similar trend with stability and droplet size. As the average particle size decreased (or stability increased), the emulsion viscosity increased.
Operational resilience metrics for power systems with penetration of renewable resources
Authors: Gui Jianzhong , Lei Hangtian , McJunkin Timothy R. , Chen Bo , Johnson Brian K. 
Published: March 2023

AbstractModern power grid is evolving towards carbon neutrality by deploying increasing amount of renewable energy resources. However, the impact of renewable generation on power system planning and operation is not sufficiently investigated, especially the capability of renewable penetrated power systems to resist and recover from major disturbances, which is a critical concern for system operators. Novel metrics and evaluation methodologies are needed to depict systems’ ability in response to events caused by natural disasters, and quantitatively evaluate system performance in various time scales. In this paper, operational resilience metrics are proposed for power systems with penetration of renewable energy resources based on transient stability principles. A systematic methodology is proposed to quantitatively assess the evolution of system performance during various stages of the disaster process. Based on the proposed metrics, a resilience‐oriented disaster management strategy is designed and validated using the modified IEEE 39‐bus test system. The simulation results demonstrate the validity of the proposed metrics and strategy, and show that the system resilience is enhanced during the mitigation of fault conditions.
Introducing the READY Study: DHH Young people’s Well-Being and Self-Determination
Authors: Young Alys , Espinoza Francisco , Dodds Claire , Squires Garry , Rogers Katherine , Chilton Helen , O’Neill Rachel 
Published: March 2023

Abstract
READY is a self-report prospective longitudinal study of deaf and hard of hearing (DHH) young people aged 16 to 19 years on entry. Its overarching aim is to explore the risk and protective factors for successful transition to adulthood. This article introduces the cohort of 163 DHH young people, background characteristics and study design. Focusing on self-determination and subjective well-being only, those who completed the assessments in written English (n = 133) score significantly lower than general population comparators. Sociodemographic variables explain very little of the variance in well-being scores; higher levels of self-determination are a predictor of higher levels of well-being, outweighing the influence of any background characteristics. Although women and those who are LGBTQ+ have statistically significantly lower well-being scores, these aspects of their identity are not predictive risk factors. These results add to the case for self-determination interventions to support better well-being amongst DHH young people.
Social Networking Site Usage of Middle-Aged and Older Deaf Adults
Authors: Paglieri Taylor A , Schooler Deborah , Pezzarossi Caroline Kobek 
Published: March 2023

Abstract
Social networking sites (SNS) have become increasingly popular in modern society; however, there is insufficient research into the impacts of SNS use on middle-aged and older Deaf and hard-of-hearing (D/HH) individuals. D/HH SNS users belonging to the Baby Boomer generation or Generation X (born 1946–1980) were recruited for this study. A mixed-methods approach was utilized, with a survey (n = 32) and interviews (n = 3), to examine primary reasons for use, perceived accessibility of interactions, the relationship between SNS use and life satisfaction, and the impacts of SNS use on this population. SNS platforms were found to be primarily used for social interaction, information seeking, and entertainment purposes. This study further showed that SNS interactions with hearing individuals were significantly more accessible than in-person interactions. The thematic analysis of the qualitative data revealed four key themes: exposure and representation, accessibility and social connection, privacy, and ideological polarization. The overall feelings towards these platforms were positive. SNS platforms allowed for increased accessibility through reducing communication barriers. Additionally, as SNS platforms have become increasingly prevalent, participants noted increased representation of the Deaf community within movies and television. This preliminary information sets important groundwork for future research, which can be used to increase the positive impacts for other D/HH individuals.
Generic and Branded Pharmaceutical Pricing: Competition Under Switching Costs*
Authors: Janssen Aljoscha 
Published: March 2023

Abstract
This article examines pricing in pharmaceutical markets where branded products face competition from generics. After providing evidence for brand premia and switching costs using prescription-level and matched socioeconomic data for the entire Swedish population, I estimate a dynamic oligopoly model and evaluate counterfactual policies that reduce the impact of frictions on pricing. Lengthening the procurement period reduces the impact of switching costs on prices. The policy increases prices on average, but more so for individuals with infrequent consumption, high education and income. In a counterfactual where brand choice decisions are moved from patients to medical experts, prices fall substantially.
The Effects of Fiscal Decentralisation on Publicly Provided Services and Labour Markets
Authors: Bianchi Nicola , Giorcelli Michela , Martino Enrica Maria 
Published: March 2023

Abstract
This paper studies how fiscal decentralisation affects labour supply. It explores a reform that increased the fiscal autonomy of Italian municipalities by replacing government transfers with revenues from a local property tax. Our identification leverages cross-municipal variation in the degree of decentralisation that stems from differences in the average age of buildings caused by World War II bombings. Decentralisation expanded municipal services, such as nursery schools, especially in areas with greater political competition. The paper then investigates how the reform affected labour markets. Decentralisation increased female labour supply—probably through expanded availability of nursery schools—thereby reducing the gender gap in employment.
ANMCO position paper: guide to the appropriate use of the wearable cardioverter defibrillator in clinical practice for patients at high transient risk of sudden cardiac death
Authors: Casolo Giancarlo , Gulizia Michele Massimo , Aschieri Daniela , Chinaglia Alessandra , Corda Marco , Nassiacos Daniele , Caico Salvatore Ivan , Chimenti Cristina , Giaccardi Marzia , Gotti Enrico , Maffé Stefano , Magnano Roberta , Solarino Gianluca , Gabrielli Domenico , Oliva Fabrizio , Colivicchi Furio 
Published: March 2023

Abstract
Extended risk stratification and optimal management of patients with a permanently increased risk of sudden cardiac death (SCD) are becoming increasingly important. There are several clinical conditions where the risk of arrhythmic death is present albeit only transient. As an example, patients with depressed left ventricular function have a high risk of SCD that may be only transient if there will be a significant recovery of function. It is important to protect the patients while receiving and titrating to the optimal dose the recommended drugs that may lead to an improved left ventricular function. In several other conditions, a transient risk of SCD can be observed even if the left ventricular function is not compromised. Examples are patients with acute myocarditis, during the diagnostic work-up of some arrhythmic conditions or after extraction of infected catheters while eradicating the associated infection. In all these conditions, it is important to offer a protection to these patients. The wearable cardioverter defibrillator (WCD) is of particular importance as a temporary non-invasive technology for both arrhythmia monitoring and therapy in patients with increased risk of SCD. Previous studies have shown the WCD to be an effective and safe therapy for the prevention of SCD caused by ventricular tachycardia/fibrillation. The aim of this ANMCO position paper is to provide a recommendation for clinical utilization of the WCD in Italy, based upon current data and international guidelines. In this document, we will review the WCD functionality, indications, clinical evidence, and guideline recommendations. Finally, a recommendation for the utilization of the WCD in routine clinical practice will be presented, in order to provide physicians with a practical guidance for SCD risk stratification in patients who may benefit from this device.
Recent range shifts of moths, butterflies, and birds are driven by the breadth of their climatic niche
Authors: Hällfors Maria H , Heikkinen Risto K , Kuussaari Mikko , Lehikoinen Aleksi , Luoto Miska , Pöyry Juha , Virkkala Raimo , Saastamoinen Marjo , Kujala Heini 
Published: March 2023

Abstract
Species are altering their ranges as a response to climate change, but the magnitude and direction of observed range shifts vary considerably among species. The ability to persist in current areas and colonize new areas plays a crucial role in determining which species will thrive and which decline as climate change progresses. Several studies have sought to identify characteristics, such as morphological and life-history traits, that could explain differences in the capability of species to shift their ranges together with a changing climate. These characteristics have explained variation in range shifts only sporadically, thus offering an uncertain tool for discerning responses among species. As long-term selection to past climates have shaped species’ tolerances, metrics describing species’ contemporary climatic niches may provide an alternative means for understanding responses to on-going climate change. Species that occur in a broader range of climatic conditions may hold greater tolerance to climatic variability and could therefore more readily maintain their historical ranges, while species with more narrow tolerances may only persist if they are able to shift in space to track their climatic niche. Here, we provide a first-filter test of the effect of climatic niche dimensions on shifts in the leading range edges in three relatively well-dispersing species groups. Based on the realized changes in the northern range edges of 383 moth, butterfly, and bird species across a boreal 1,100 km latitudinal gradient over c. 20 years, we show that while most morphological or life-history traits were not strongly connected with range shifts, moths and birds occupying a narrower thermal niche and butterflies occupying a broader moisture niche across their European distribution show stronger shifts towards the north. Our results indicate that the climatic niche may be important for predicting responses under climate change and as such warrants further investigation of potential mechanistic underpinnings.