bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drilling-System Optimization Leads to Expedited Wells Delivery
Authors: Carpenter Chris 
Published: January 2023

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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 202172, “Drilling System Optimization Leads to Expedited Wells Delivery,” by Efe M. Ovwigho, SPE, Saleh Al Marri, and Abdulaziz Al Hajri, Schlumberger. The paper has not been peer reviewed.

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The authors write in the complete paper that simple changes in drillstring design can lead to huge savings in a climate requiring a constant push for reduction in well times and well costs and in improved well delivery. The complete paper explains the process that was followed before implementation of this solution.

Introduction
To access hydrocarbon reserves in a deep gas field, directional drilling through highly interbedded and abrasive formations was necessary. Designing a fit-for-purpose drilling system for optimal performance was critical. The reservoir drainage strategy required that the development wells be drilled directionally to attain a horizontal displacement of 1,500–2,500 ft at the 7-in. liner point above the gas reservoir formation.
The well architecture was designed such that the well would be landed in the 8⅜-in. hole section. This required building inclination from vertical (0°) and landing the well at 80° inclination. Then, 4,000–5,000 ft of a 5⅞-in. hole lateral section would be drilled while holding 80° inclination or occasionally building to 90° inclination.
Several initiatives had been implemented with the aim of optimizing drilling performance but had not experienced meaningful success in tackling vibration issues.

Design Background
An analysis of more than 100 horizontal wells drilled on the project revealed that 35% of total well time was consumed in the 8⅜-in. hole section. The majority of this time was spent on slow drilling or remedial operations. It was imperative that the proposed engineered drillstring meet the following requirements:
- Able to drill through highly abrasive and interbedded formations
- Maintain stability to avoid or reduce stick/slip, shocks, and vibration
- Address surge and swab concerns
- Minimize exposure through reduced handling
- Optimize torque and drag
- Optimized based on available tubulars on the rigsite
- Reduce flat time
Finite element analysis (FEA) and bottomhole assembly (BHA) modeling was performed with these requirements taken into consideration in a bid to generate a fit-for-purpose BHA (Fig. 1).
In the deep gas field where the study was completed, the well had to be landed in the reservoir formation and maintain the 5⅞-in. lateral across the entire pay zone.
A critical analysis of the formation determined that compressive strength exceeded 30,000 psi and that the formation was highly abrasive. A complete review of the drilling system was completed to optimize the approach to be taken.
Formin-mediated nuclear actin assembly at androgen receptors
promotes transcriptional droplet formation
Authors: Knerr Julian , Werner Ralf , Schwan Carsten , Wang Hong , Gebhardt Peter , Grötsch Helga , Caliebe Almuth , Spielmann Malte , Holterhus Paul-Martin , Grosse Robert , Hornig Nadine 
Published: January 2023

Abstract
Steroid hormone receptors are ligand-binding transcription factors essential for mammalian physiology. The androgen receptor (AR) binds androgens mediating gene expression for sexual, somatic, and behavioral functions, and is involved in various conditions including androgen-insensitivity-syndrome (AIS) or prostate cancer. Here we identified functional AIS-patient mutations in the formin and actin nucleator DAAM2. DAAM2 localized to the nucleus and colocalized with the AR to form actin-dependent transcriptional droplets in response to dihydrotestosterone. DAAM2-AR-droplets ranged from 0.02 to 0.06 µm3 in size and associated with active RNA polymerase II. DAAM2 polymerizes actin directly at the AR to promote droplet fusion in a highly dynamic manner and actin polymerization is required for prostate-specific antigen expression in cancer cells. Our data uncover signal-regulated nuclear actin assembly at a steroid hormone receptor necessary for transcription.
N-butanol fraction of Olax subscorpioidea Oliv. (Olacaceae) attenuates lipopolysaccharide-induced depressive-like symptoms in mice.
Authors: Adeoluwa Olusegun Adebayo , Agboola Isaiah , Akinluyi Elizabeth , Eduviere Anthony , Adeoluwa Gladys , Ajayi Abayomi , Aderibigbe Adegbuyi 
Published: February 2023

Abstract
Background: The leaves of Olax subscorpioidea have become a mainstay in the management of inflammatory diseases and mental illness in folkloric medicine in Nigeria. Previous studies have shown its antidepressant and anti-inflammatory properties in experimental animals. Recently its antidepressant action was linked to the involvement of monoaminergic transmission. However, with accumulating evidences suggesting link between immuno-inflammatory signaling pathways and depression, there is dearth of information about its beneficial effect on inflammation associated depression. We thus evaluated the effect of n-butanol fraction of O. subscorpioidea leaves on lipopolysaccharide (LPS)-induced depressive-like behaviours and investigated its antidepressant effect with respect to its action on inflammatory and oxidative pathways.
Methods: Fifty Swiss male mice were randomly assigned into five groups (n= 10): group 1 (vehicle only), group 2 (nBFOS 5mg/kg), group 3 (nBFOS 10 mg/kg), group 4 (imipramine 10 mg/kg), group 5 (vehicle). Mice were treated with vehicle or nBFOS (5 & 10 mg/kg) or imipramine intraperitoneal for seven days. Thirty minutes after treatment on day seven, animals were injected with LPS (0.83 mg/kg, i.p.) except group 1 (vehicle only). Twenty-four hours following LPS injection, animals were assessed for depressive symptoms using sucrose preference test and immobility using tail suspension test (TST). Brain levels of pro-inflammatory mediators interleukin-1β (IL-1β) and tumor necrosis factor (TNF), oxidative stress biomarkers (malondialdehyde and reduced glutathione) and plasma level of corticosterone were measured by Enzyme Linked immunosorbent assay.
Results: LPS significantly (p < 0.05) increased immobility of mice in TST and decreased sucrose preference which is indicative of depressive-like behaviours. The depressive behaviours were significantly (p < 0.05) attenuated by nBFOS and imipramine compared to control. Furthermore, LPS-induced increase in malondialdehyde, corticosterone, TNF, IL-1β, and decrease in reduced glutathione, in the brain were significantly reversed by treatment with nBFOS and imipramine.
Conclusion: The findings suggest that attenuation of LPS-induced depressive-like behaviours by the fraction of O. subscorpioidea leaves may be related to suppression of oxidative stress and inhibitory effect on inflammatory mediators in the central nervous system.
Meta-analysis of the relationship between bullying and depressive symptoms in children and adolescents
Authors: Ye Zixiang , Wu Dongmei , He Xiaoyan , Ma Qin , Peng Jianyan , Mao Guoju , Feng Lanling , Tong Yuhao 
Published: January 2023

Abstract
Childhood and adolescence are critical periods for physical and mental development; thus, they are high-risk periods for the occurrence of mental disorders. The purpose of this study was to systematically evaluate the association between bullying and depressive symptoms in children and adolescents. We searched the PubMed, MEDLINE and other databases to identify studies related to bullying behavior and depressive symptoms in children and adolescents. A total of 31 studies were included, with a total sample size of 133,688 people. The results of the meta-analysis showed that the risk of depression in children and adolescents who were bullied was 2.77 times higher than that of those who were not bullied, that the risk of depression in bullying individuals was 1.73 times higher than that in nonbullying individuals, and that the risk of depression in individuals who bullied and experienced bullying was 3.19 times higher than that in nonbullying-bullied individuals. This study confirmed significant associations of being bullied, bullying, and bullying-bullied behavior with depression in children and adolescents. However, these findings are limited by the quantity and quality of the included studies and need to be confirmed by future studies.
Index of Financial Inclusion and its Relationship with Human Development: Comparative Study of Composite Index and Sarma Analysis
Authors: samputra palupi lindiasari 
Published: January 2023

Abstract

This study to find the dimensions and weights as the best measure of the financial inclusion index by comparing the Sarma analysis with the Composite Index, then analyzing its relationship to human development. The quantitative approach uses Factor Analysis followed by Fixed Effect Model. The data sample is 217 countries grouped by income level from 2011 to 2017. It was found that Access and Usage are two essential dimensions of the financial inclusion index, with the weight of Access (0.60) greater than usage (0.4). Human development acts as an intervening variable and has a significant effect on increasing financial inclusion.
FGFR blockade inhibits targeted therapy-tolerant persister cells in basal FGFR1 and FGF2 high expressing cancers with driver oncogenes
Authors: Yoshiura Shigeki , Furugaki Koh , Fujimura Takaaki , Yoshimura Yasushi , Yoshimoto Takuya , Asakawa Takashi 
Published: January 2023

Abstract
Cancer cell resistance arises when tyrosine kinase inhibitor (TKI)-targeted therapies induce a drug-tolerant persister (DTP) state with growth via genetic aberrations, making DTP cells potential therapeutic targets. We screened an anti-cancer compound library and identified fibroblast growth factor receptor 1 (FGFR1) promoting alectinib-induced ALK fusion-positive DTP cell's survival. FGFR1 signaling promoted DTP cell survival generated from basal FGFR1- and FGF2-high expressing cells, following alectinib treatment, which is blocked by FGFR inhibition. The hazard ratio for progression-free survival of ALK-TKIs tended to increase in ALK fusion-positive non-small cell lung cancer patients with FGFR1- and FGF2-high expression. Combination of FGFR and targeted TKIs enhanced cell growth inhibition in FGFR1- and FGF2-high expressing cells with ALK fusion, HER2 amplification, and EGFR or BRAF mutations. Initial dual blockade of FGFR and various driver oncogenes based on FGFR1 and FGF2 expression levels before starting treatment would be a potent treatment strategy to prevent intrinsic resistance to targeted TKIs through DTP cells.
Vendor Evaluation Platform for Acquisition of Medical Equipment based on Multi-Criteria Decision-Making Approach
Authors: Saleh Neven , Gaber Mohamed N. , Eldosoky Mohamed A. , Soliman Ahmed M. 
Published: February 2023

AbstractBackground The purchase of medical equipment is a critical issue that should be planned properly. The selection of the most appropriate vendor impacts time, effort, and expenses. Therefore, the challenge is to strike a balance between the available budget and the required equipment. The study aims to select the best vendor for supplying medical equipment based on Emergency Care Research Institute (ECRI) standards. Methods The multi-criteria decision-making approach has been adopted through three methods; Multi-Objective Optimization by Ratio Analysis (MOORA), Simple Additive Weighting (SAW), and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). The criteria of selection are divided into general, technical, and financial. The criteria are weighted using three methods: CRITIC, entropy, and expert judgment. The Vendor Evaluation Program for Medical Equipment (VEPME) is designed to automatically select the best vendor. Results Medical imaging equipment is selected to test the program by four modalities: X-ray equipment, CT, MRI, and ultrasound. The best scenario was given by the entropy-TOPSIS. As a result, this methodology was adopted by the program. Conclusions The results demonstrate the robustness of the proposed methodology by comparing the VEPME output to expert judgment.
The global apparel industry: a significant, yet overlooked source of plastic leakage
Authors: Kounina Anna , Daystar Jesse , Chalumeau Sophie , Devine Jon , Geyer Roland , Pires Steven , Sonar Shreya , Venditti Richard , Boucher Julien 
Published: January 2023

Abstract

This study is the first comprehensive assessment of the global apparel industry’s contribution to plastic pollution. It includes leakage of packaging and end-of-life apparel waste in addition to fiber emissions during apparel production and use. We estimate that the apparel industry generated 9.2 [5.5 – 13] million tons (Mt) of plastic pollution in 2019, corresponding to 15% [6.3% – 31%] of the estimated 61 Mt from all sectors. The main source of plastic pollution from the apparel supply chain is synthetic clothing as mismanaged waste either in the country of its original use or in the countries receiving used apparel exports. A fundamental transformation of the apparel economy towards a circular framework along with decreased synthetic apparel consumption is needed to tackle apparel-related plastic pollution.
Association Between Breakfast Cereals and Risk of Cardiovascular Diseases and Type 2 Diabetes: A Mendelian Randomization Study
Authors: Cheng Tao , Shi Shuqing , Zhang Xuesong , Duan Chenglin , Yun Zhangjun , Hu Yuanhui 
Published: February 2023

Abstract
Background: Evidence suggests that cereals are associated with cardiovascular diseases and type 2 diabetes. However, the results from existing studies are inconsistent and the causality remains to be determined. In this study, we used Mendelian randomization analysis to evaluate the potential causal relationship between breakfast cereals and cardiovascular diseases and type 2 diabetes.
Methods: We accessed summary data of breakfast cereals from genome-wide association studies (GWAS) involving 299,898 people. Additionally, we accessed summary data on cardiovascular diseases from FinnGen R7. Mendelian randomization analysis using inverse variance-weighting (IVW) served as the main analytical method. Besides, multiple sensitivity analysis methods were performed to ensure that the results were robust.
Results: Among breakfast cereals, bran cereal, biscuit cereal, oat cereal, and other types of breakfast cereal were not linked to a risk of cardiovascular diseases and type 2 diabetes, according to gene prediction results. However, genetic liability to muesli was significantly associated with a reduced risk of hypertension (odds ratio (OR) = 0.090; 95% confidence interval (CI) = 0.012-0.660; P = 0.018), myocardial infarction (OR = 0.154; 95% CI = 0.030-0.787; P = 0.025), type 2 diabetes (OR = 0.078; 95% CI = 0.017-0.350; P = 0.00086), and stroke (OR = 0.189; 95% CI = 0.048-0.733; P = 0.016). Further analysis showed no evidence of pleiotropy.
Conclusions: Our research offers genetic support for a possible causal link between muesli and hypertension, myocardial infarction, type 2 diabetes, and stroke.
The episodic resurgence of highly pathogenic avian influenza H5 virus
Authors: Dhanasekaran Vijaykrishna , Xie Ruopeng , Edwards Kimberly , Wille Michelle , Wei Xiaoman , Wong Sook-san , Zanin Mark , El-Shesheny Rabeh , Ducatez Mariette , Poon Leo , Kayali Ghazi , Webby Richard 
Published: January 2023

Abstract
Highly pathogenic avian influenza (HPAI) H5N1 activity has intensified globally since 2021, replacing the dominant clade 2.3.4.4 H5N8 virus. H5N1 viruses have spread rapidly to four continents, causing increasing reports of mass mortality in wild birds and poultry. The ecological and virological properties required for future mitigation strategies are unclear. Using epidemiological, spatial and genomic approaches, we demonstrate changes in the source of resurgent H5 HPAI and reveal significant shifts in virus ecology and evolution. Outbreak data indicates key resurgent events in 2016/17 and 2020/21 that contributed to the panzootic spread of H5N1 in 2021/22, including an increase in virus diffusion velocity and persistence in wild birds. Genomic analysis reveals that the 2016/17 epizootics originated in Asia, where HPAI H5 reservoirs are documented as persistent. However, in 2020/21, 2.3.4.4b H5N8 viruses emerged in domestic poultry in Africa, featuring several novel mutations altering the HA structure, receptor binding, and antigenicity. The new H5N1 virus emerged from H5N8 through reassortment in wild birds along the Adriatic flyway around the Mediterranean Sea. It was characterized by extensive reassortment with low pathogenic avian influenza in domestic and wild birds as it spread globally. In contrast, earlier outbreaks of H5N8 were caused by a more stable genetic constellation, highlighting dynamic changes in HPAI H5 genomic evolution. These results suggest a shift in the epicenter of HPAI H5 beyond Asia to new regions in Africa, the Middle East, Europe, and North and South America. The persistence of HPAI H5 with resurgence potential in domestic birds indicates that elimination strategies remain a high priority.
Cardiac MRI to guide heart failure and atrial fibrillation drug discovery: a Mendelian randomization analysis
Authors: Schmidt Amand , Finan Chris , Bourfiss Mimount , Velthuis Birgitta , Puyol-Antón Esther , Alasiri Abdulrahman , Ruijsink Bram , Asselbergs Folkert , Riele Anneline ter , Setten Jessica van 
Published: February 2023

Abstract
Background
drug development and disease prevention of heart failure (HF) and atrial fibrillation (AF) are impeded by a lack of robust early-stage surrogates. We determined to what extent cardiac magnetic resonance (CMR) measurements act as surrogates for the development of HF or AF in healthy individuals.
Methods
Genetic data was sourced on the association with 22 atrial and ventricular CMR measurements. Mendelian randomization was used to determine CMR associations with atrial fibrillation (AF), heart failure (HF), non-ischemic cardiomyopathy (CMP), and dilated cardiomyopathy (DCM). Additionally, for the CMR surrogates of AF and HF, we explored their association with non-cardiac traits.
Results
In total we found that 9 CMR measures were associated with the development of HF, 7 with development of non-ischemic CMP, 6 with DCM, and 12 with AF. biventricular ejection fraction (EF), biventricular or end-systolic volumes (ESV) and left-ventricular (LV) end diastolic volume (EDV) were associated with all 4 cardiac outcomes. Increased LV-MVR (mass to volume ratio) affected HF (odds ratio (OR) 0.83, 95%CI 0.79; 0.88), and DCM (OR 0.26, 95%CI 0.20; 0.34. We were able to identify 9 CMR surrogates for HF and/or AF (including LV-MVR, biventricular EDV, ESV, and right-ventricular EF) which associated with non-cardiac traits such as blood pressure, lung function traits, BMI, cardioembolic stroke, and late-onset Alzheimer’s disease.
Conclusion
CMR measurements may act as surrogate endpoints for the development of HF (including non-ischemic CMP and DCM) or AF. Additionally, we show that changes in cardiac function and structure measured through CMR, may affect diseases of other organs leading to lung disease or late-onset Alzheimer’s disease.
Flavones provide resistance to DUX4-induced toxicity via an mTor-independent mechanism
Authors: Cohen Justin , Huang Shushu , Koczwara Katherine , Ho Vincent , Woodman Keryn , Lek Angela , Arbiser Jack , Lek Monkol , DeSimone Alec 
Published: February 2023

Abstract

Facioscapulohumeral muscular dystrophy (FSHD) is among the most common of the muscular dystrophies, affecting nearly 1 in 8000 individuals, and is a cause of profound disability. Genetically, FSHD is linked to the contraction and/or epigenetic de-repression of the D4Z4 repeat array on chromosome 4, thereby allowing expression of the DUX4 gene in skeletal muscle. If the DUX4 transcript incorporates a stabilizing polyadenylation site the myotoxic DUX4 protein will be synthesized, resulting in muscle wasting. The mechanism of toxicity remains unclear, as many DUX4-induced cytopathologies have been described, however cell death does primarily occur through caspase 3/7-dependent apoptosis. To date, most FSHD therapeutic development has focused on molecular methods targeting DUX4 expression or the DUX4 transcript, while therapies targeting processes downstream of DUX4 activity have received less attention. Several studies have demonstrated that inhibition of multiple signal transduction pathways can ameliorate DUX4-induced toxicity, and thus compounds targeting these pathways have the potential to be developed into FSHD therapeutics. To this end, we have screened a group of small molecules curated based on their reported activity in relevant pathways and/or structural relationships with known toxicity-modulating molecules. We have identified a panel of five compounds that function downstream of DUX4 activity to inhibit DUX4-induced toxicity. Unexpectedly, this effect was mediated through an mTor-independent mechanism that preserved expression of ULK1 and correlated with an increase in a marker of active cellular autophagy. This identifies these flavones as compounds of interest for therapeutic development, and potentially identifies the autophagy pathway as a target for therapeutics.
Efficient segmentation algorithm for estimation of revised reservoir capacities in Google Earth Engine
Authors: Jaiswal Rahul , Dhruw Gunja , Jain Sukant , Galkate Ravi V , Lohani Anil K , Verma Akhilesh 
Published: February 2023

Abstract

The periodic assessment of the revised capacity is essential and conventional techniques through bathymetric surveys and inflow-outflow techniques are time and resource intensive. The unsupervised classification of optical remote sensing data is practiced for a long time to reduce the cost of the survey but has the limitation of selecting threshold values and inefficacy of the method during the cloudy season. This research proposed the application of the Otsu segmentation technique in Google Earth Engine (GEE) to determine revised water spread using microwave data. The Otsu technique is efficient in classifying the image into two distinct classes using within and between-class variances (Bangare et al 2015). An application has been developed using Sentinel data in GEE, which has the capacity of cloud-based computing and applied to the four reservoirs of Mahanadi Reservoir Project (MRP) namely Ravishankar Sagar, Murumsilli, Dudhawa, and Sondur reservoir in the Chhattisgarh state of India. The original capacities of these reservoirs vary from 910.51 MCM of Ravishankar (RS) Sagar to 165.89 MCM of Murumsilli reservoir. The revised water spreads computed in the GEE were further used to compute revised volume and in turn the revised cumulative capacities at different levels. The analysis suggested that 17.65% of dead storage (118.26 MCM from 143.00 MCM) and 9.25% of gross storage (85.26 MCM from 910.52 MCM) of RS Sagar has been lost in 42 years (1978 to 2020). Similarly, 10.33% gross capacity of Murumsilli, 13.12% of Sondur, and 12.37% of Dudhawa reservoirs has been lost due to the deposit of sediments from the catchments, and results were found comparable with bathymetric survey results of three reservoirs. The proposed application has been developed in GEE so it can be used in any part of the world in cloudy weather with no human interference.