bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automastoidectomy — a case report
Authors: Seedahmed Khalid Mahmoud Sayed , Abujabal Tareq A. Y. , Akoud Fatima Ayed 
Published: August 2023

Abstract
Background
Automastoidectomy denotes extensive destruction of the middle ear cavity and the mastoid air cells, mimicking the appearance of a reminiscent image of the post-mastoidectomy cavity. This condition, although rare, might occur as a unique complication of chronic otitis media with cholesteatoma with subsequent destruction of the posterior wall of the external auditory canal and spontaneous partial or complete evacuation of the cholesteatoma through the canal.

Case presentation
Seventy-year-old gentleman, a retired soldier, presented to us in the ENT OPD with right ear pain for more than a year, right ear discharge for 9 months, and a decrease in the hearing of the right ear for 6 months. The condition started 18 months ago with intermittent right otalgia; Dull aching in nature. Ten months later, the patient started to experience right-sided otorrhoea which was profuse, offensive, mucopurulent, and yellowish in color. Later on, he noticed a gradually deteriorating hearing.
On examination of the right ear, there is a fleshy mass obstructing the EAC, no auricular deformity tenderness, no preauricular swelling, sinus, or deformity, and there is thinning of the skin in the right postauricular region with mild tenderness but no swelling or sinus and preserved sulcus. Otoscopic examination shows a mass obstructing the EAC found to be an everted skin tag from the posteroinferior wall of the canal. There was a widening of the canal with the destruction of the walls and the absence of the TM, the annulus tympanicum, and the ossicles with polypoidal mucosa all over the middle ear cavity.

Investigation
HRCT scan of the temporal bone shows destruction of the air cells of the right mastoid cavity with the absence of the ossicles and destruction of the posterior EAC walls.

Conclusion
Although uncommon it is considered to be a known complication of Cholesteatomatous otitis media and sometime keratosis obturates with the main feature of osteogenic destruction of the posterior wall of the EAC.
Knowledge, attitudes, practices, and compliance of rheumatic disease patients toward COVID-19 during the late pandemic
Authors: Ismail Zahraa Nour Eldine , Ibrahim Omar Nabil , Ghaly Mona Sayed , Ibrahim Maha Emad 
Published: August 2023

Abstract
Background
Rheumatic disease (RD) patients are liable for severe coronavirus disease 2019 (COVID-19). It is noticeable that RD patients’ practices have changed during the late COVID-19 pandemic. This study aimed to assess the knowledge, attitudes, practices, and compliance of RD patients during the late pandemic.

Results
This study included 188 patients with various RDs. The majority were female (61.7%) and were rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients (40.4% and 30.9%, respectively). We found knowledge deficiencies regarding some symptoms, contact isolation, and transmission. Negative attitudes toward COVID-19 final control were detected in a large proportion (50%). Furthermore, the majority did not think they were at risk of COVID-19 due to either RD (61.7%) or their drugs (66%). Their practices were also negative; the majority stopped wearing masks (56.4%) and went to crowded places recently (83%). Moreover, most did not stop or reduce their drugs for fear of COVID-19 but for availability issues (5.3% and 9.6% vs. 37.2%). Male gender and higher education and socioeconomic levels were significantly associated with better knowledge. In addition, RDs such as reactive arthritis, steroid use, lower steroid doses, COVID-19 vaccination, high education and socioeconomic levels, and Internet use as main knowledge sources had a significant association with better attitudes. Conventional disease-modifying anti-rheumatic drugs (DMARDs) use, biologics non-use, high education, severe functional impact, and compliance before the pandemic were significantly associated with higher practice scores. Knowledge was positively correlated with attitudes and practice (P = 0.0001 and 0.003, respectively). Moreover, attitudes were negatively correlated with age (P = 0.016). In multiple linear regression analysis, education, socioeconomic status, and practice were significant positive predictors of knowledge (P = 0.002, 0.001, and 0.046, respectively). Good knowledge, COVID-19 vaccination, younger age, and lower steroid doses were significant predictors of better attitudes (P = 0.02, 0.001, 0.02, and 0.002, respectively). Furthermore, non-use of biologics and functional disability were significant predictors of good practice (P = 0.002 and 0.015, respectively).

Conclusion
Improving knowledge and educating RD patients about the importance of protective measures is essentially needed to decrease the pandemic fatigue consequences and prevent serious COVID-19 complications in those patients.
The Cholangiocarcinoma in the Young (CITY) Study: Tumor Biology, Treatment Patterns, and Survival Outcomes in Adolescent Young Adults With Cholangiocarcinoma
Authors: Pappas Leontios , Baiev Islam , Reyes Stephanie , Bocobo Andrea Grace , Jain Apurva , Spencer Kristen , Le Tri Minh , Rahma Osama E. , Maurer Jordan , Stanton Jen , Zhang Karen , De Armas Anaemy Danner , Deleon Thomas T. , Roth Marc , Peters Mary Linton B. , Zhu Andrew X. , Boyhen Kylie , VanCott Christine , Patel Tushar , Roberts Lewis R. , Lindsey Stacie , Horick Nora , Lennerz Jochen K. , Iafrate A. John , Goff Laura Williams , Mody Kabir , Borad Mitesh J. , Shroff Rachna T. , Javle Milind M. , Kelley R. Katie , Goyal Lipika 
Published: August 2023

PURPOSE Increased awareness of the distinct tumor biology for adolescents and young adults (AYAs) with cancer has led to improvement in outcomes for this population. However, in cholangiocarcinoma (CCA), a paucity of data exist on the AYA population. To our knowledge, we present the largest study to date on AYA disease biology, treatment patterns, and survival outcomes in CCA. METHODS A multi-institutional cohort of patients with CCA diagnosed with intrahepatic cholangiocarcinoma (ICC) or extrahepatic cholangiocarcinoma (ECC) was used for analysis. Retrospective chart review was conducted on patients who were 50 years old and younger (young; n = 124) and older than 50 years (older; n = 723). RESULTS Among 1,039 patients screened, 847 patients met eligibility (72% ICC, 28% ECC). Young patients had a larger median tumor size at resection compared with older patients (4.2 v 3.6 cm; P = .048), more commonly had N1 disease (65% v 43%; P = .040), and were more likely to receive adjuvant therapy (odds ratio, 4.0; 95% CI, 1.64 to 9.74). Tumors of young patients were more likely to harbor an FGFR2 fusion, BRAF mutation, or ATM mutation ( P < .05 for each). Young patients were more likely to receive palliative systemic therapy (96% v 69%; P < .001), targeted therapy (23% v 8%; P < .001), and treatment on a clinical trial (31% v 19%; P = .004). Among patients who presented with advanced disease, young patients had a higher median overall survival compared with their older counterparts (17.7 v 13.5 months; 95% CI, 12.6 to 22.6 v 11.4 to 14.8; P = .049). CONCLUSION Young patients with CCA had more advanced disease at resection, more commonly received both adjuvant and palliative therapies, and demonstrated improved survival compared with older patients. Given the low clinical trial enrollment and poor outcomes among some AYA cancer populations, data to the contrary in CCA are highly encouraging.
A Year at the Forefront of Hydrostat Motion
Authors: Schulz Andrew K. , Schneider Nikole , Zhang Margaret , Singal Krishma 
Published: August 2023

ABSTRACT
Currently, in the field of interdisciplinary work in biology, there has been a significant push by the soft robotic community to understand the motion and maneuverability of hydrostats. This Review seeks to expand the muscular hydrostat hypothesis toward new structures, including plants, and introduce innovative techniques to the hydrostat community on new modeling, simulating, mimicking, and observing hydrostat motion methods. These methods range from ideas of kirigami, origami, and knitting for mimic creation to utilizing reinforcement learning for control of bio-inspired soft robotic systems. It is now being understood through modeling that different mechanisms can inhibit traditional hydrostat motion, such as skin, nostrils, or sheathed layered muscle walls. The impact of this Review will highlight these mechanisms, including asymmetries, and discuss the critical next steps toward understanding their motion and how species with hydrostat structures control such complex motions, highlighting work from January 2022 to December 2022.
Global SUMOylation in mouse oocytes maintains oocyte identity and regulates chromatin remodeling and transcriptional silencing at the end of folliculogenesis
Authors: Briley Shawn M. , Ahmed Avery A. , Steenwinkel Tessa E. , Jiang Peixin , Hartig Sean M. , Schindler Karen , Pangas Stephanie A. 
Published: August 2023

ABSTRACT
Meiotically competent oocytes in mammals undergo cyclic development during folliculogenesis. Oocytes within ovarian follicles are transcriptionally active, producing and storing transcripts required for oocyte growth, somatic cell communication and early embryogenesis. Transcription ceases as oocytes transition from growth to maturation and does not resume until zygotic genome activation. Although SUMOylation, a post-translational modification, plays multifaceted roles in transcriptional regulation, its involvement during oocyte development remains poorly understood. In this study, we generated an oocyte-specific knockout of Ube2i, encoding the SUMO E2 enzyme UBE2I, using Zp3-cre+ to determine how loss of oocyte SUMOylation during folliculogenesis affects oocyte development. Ube2i Zp3-cre+ female knockout mice were sterile, with oocyte defects in meiotic competence, spindle architecture and chromosome alignment, and a premature arrest in metaphase I. Additionally, fully grown Ube2i Zp3-cre+ oocytes exhibited sustained transcriptional activity but downregulated maternal effect genes and prematurely activated genes and retrotransposons typically associated with zygotic genome activation. These findings demonstrate that UBE2I is required for the acquisition of key hallmarks of oocyte development during folliculogenesis, and highlight UBE2I as a previously unreported orchestrator of transcriptional regulation in mouse oocytes.
Successful Breast Conservation After Neoadjuvant Chemotherapy in Lobular Breast Cancer: The Role of Menopausal Status in Response to Treatment
Authors: Ramalingam Kirithiga , Clelland Elle , Rothschild Harriet , Mujir Firdows , Record Helena , Kaur Mandeep , Mukhtar Rita A. 
Published: August 2023

Abstract
Background
While neoadjuvant chemotherapy (NAC) has been shown to increase rates of breast conservation surgery (BCS) for breast cancer, response rates in invasive lobular carcinoma (ILC) appear lower than other histologic subtypes. Some data suggest higher response rates to NAC in premenopausal versus postmenopausal patients, but this has not been studied in ILC. We evaluated the rates of successful BCS after NAC in patients with ILC stratified by menopausal status.

Patients and Methods
We analyzed data from a single-institution cohort of 666 patients with stage I–III hormone receptor positive HER-2 negative ILC. We used t-tests, chi-squared tests, and multivariable logistic regression to investigate rates of NAC use, attempted BCS, and associations between NAC and successful BCS by menopausal status.

Results
In 217 premenopausal and 449 postmenopausal patients, NAC was used more often in the premenopausal group (15.2% vs. 9.8%, respectively, p = 0.041). Among those who attempted breast conservation (51.3% of pre- and 64.8% of postmenopausal cohorts), NAC was not associated with successful BCS in either group. Interestingly, for postmenopausal patients, receipt of NAC was significantly associated with increased rates of completion mastectomy in those who had positive margins at the first attempt at BCS.

Conclusion
NAC was not associated with successful BCS in either premenopausal or postmenopausal patients with ILC. Although premenopausal patients were more likely to receive NAC, these data suggest that menopausal status may not be a good predictor of response to chemotherapy. Better predictors of response and more efficacious treatment for patients with ILC are needed.
Case Report: Buprenorphine-precipitated fentanyl withdrawal treated with high-dose buprenorphine
Authors: Bormann Nicholas L. , Gout Antony , Kijewski Vicki , Lynch Alison 
Published: August 2023

Background: Buprenorphine, a partial agonist of the mu-opioid receptor, is an increasingly prescribed medication for maintenance treatment of opioid use disorder. When this medication is taken in the context of active opioid use, precipitated withdrawal can occur, leading to acute onset of opioid withdrawal symptoms. Fentanyl complicates use of buprenorphine, as it slowly releases from body stores and can lead to higher risk of precipitated withdrawal. Objectives: Describe the successful management of buprenorphine precipitated opioid withdrawal from fentanyl with high doses of buprenorphine. We seek to highlight how no adverse effects occurred in this patient and illustrate his stable transition to outpatient treatment. Case report: We present the case of a patient with severe opioid use disorder who presented in moderately severe opioid withdrawal after taking non-prescribed buprenorphine-naloxone which precipitated opioid withdrawal from daily fentanyl use. He was treated with high doses of buprenorphine, 148 mg over the first 48 hours, averaging 63 mg per day over four days. The patient reported rapid improvement in withdrawal symptoms without noted side effects and was able to successfully taper to 16 mg twice daily by discharge. Conclusions: This case demonstrates the safety and effectiveness of buprenorphine at high doses for treatment of precipitated withdrawal. While other options include symptomatic withdrawal management, initiating methadone or less researched options like ketamine, utilizing buprenorphine can preserve or re-establish confidence in this life-saving medication. This case also increases the previously documented upper boundary on buprenorphine dosing for withdrawal and should provide additional confidence in its use.
Central composite design driven optimization of sustainable stability indicating HPLC method for the determination of Tigecycline and greenness assessment
Authors: Hafez Hani Mohammed , Barghash Sona Soliman , Soliman Marwa M. , Soltan Moustafa K. , Abd Elrahman Mohamed , Katamesh Noha Salah 
Published: August 2023

Background: Tigecycline (TGC) is a recently developed antibiotic to battle resistant bacteria. The procedures outlined in the literature for analyzing TGC involve chemical solvents that could be hazardous. Therefore, this study aimed to create a sustainable and stable HPLC technique for quantifying Tigecycline in lyophilized powder. The powerful chemometric tool, experimental design (ED), will be applied to analyze the variables' interaction and impact on the selected analytical target profiles. Response surface methodology provides a tutorial on using the central composite design with three levels of variables and quadratic programming to optimize the design space of the developed method. Methods: The New HPLC method consisted of an aqueous buffer and ethanol as a green mobile phase run on a reversed-phase symmetry C18 column. A full resolution between the Tigecycline and its degradation product peaks was achieved in a short analytical runtime. Results: Further, the specificity, accuracy, precision, robustness and stability indicating power of the proposed approach were verified through stress degrading testing. Conclusions: Finally, the analytical eco-scale and the green Analytical Procedure Index (GAPI) were utilized to determine how environmentally friendly the recommended method was compared to other published approaches.
Repair of ischial tuberosity pressure ulcer with a perigluteal muscle flap
Authors: Lifeng Guan , Rahim Fazal , Awais Khan Muhammad , Tao Guo , Chao Fang , Xiaoni Wang , Saad Muhammad 
Published: August 2023

Background: Pressure ulcers are caused by long-term pressure on tissues. Hip pressure ulcers are the most common type. Pressure ulcers in the buttocks are classified into three types: sacrococcygeal, ischial tuberosity, and femoral tuberosity. Methods: We used perigluteal muscle tissue flaps to treat nine cases of grade IV pressure ulcers from January 2016 to August 2018. A retrospective study was conducted on all patients who had an ischial tuberosity pressure ulcer repaired with a perigluteal muscle flap. The gluteus maximus myocutaneous flap was combined with the gluteal fasciocutaneous flap, the biceps femoris myocutaneous flap was combined with the gluteal fasciocutaneous flap, the gracilis myocutaneous flap, the biceps femoris myocutaneous flap, and the semitendinosus and semimembranosus myocutaneous flap. Wounds of different sizes and depths were encountered, the details of which are discussed in treatment methods. Data from patients, including age, gender, cause of injury, wound dimensions, the timing of flap coverage, and complications, were analyzed. Results: The appearance of the skin flap was complete after muscular tissue flap repair, with no visible scar hyperplasia. However, after six to 12 months of follow-up, the flap was soft and left a small linear scar. Conclusions: In the repair of an ischial tuberosity pressure ulcer, a peri gluteal muscle flap provides both aesthetic and functional results. Before using muscle tissue flap transplantation, it is recommended to perform multiple debridement + VSD to improve the wound foundation.
Monkeypox and oral lesions associated with its occurrence: a systematic review and meta-analysis
Authors: Bagde Hiroj , Dhopte Ashwini , Bukhary Ferdous , Momenah Naif , Akhter Fatema , Mahmoud Okba , Shetty Krishna Prasad , Shayeb Maher AL , Abutayyem Huda , Alam Mohammad Khursheed 
Published: August 2023

Background: A zoonotic, double-stranded DNA virus belonging to the genus Orthopoxvirus, the monkeypox virus is most common in tropical regions of Central and West Africa. The frequency of monkeypox cases, however, has sharply climbed globally since May 2022. Objectives: To establish the threat of monkeypox in terms of the oral lesions caused in sufferers. Materials and methods: After a thorough study of the literature identified in the PubMed, Web of Science, and Cochrane library databases using the PRISMA framework, 103 papers were found. Using inclusion and exclusion criteria, we chose research that was relevant for our review before shortlisting 14 papers that conformed to the review's guidelines. Results: In the 14 selected studies, it was found that oral lesions were among the first clinical signs of a monkeypox affliction, with ulcers on the dorsal surface of tongue lips being the most common areas affected. Conclusion: The rarely observed oral lesions of monkeypox infection may help in the diagnosis and management of this condition. It is critical to keep in mind that recognising and detecting oral lesions in monkeypox patients opens the door to more research and efficient patient management.
Antioxidant and apoptotic activities of sitagliptin against hepatocellular carcinoma: An in vitro study
Authors: Alameen Ruqaya , Bairam Ahsan , Al-Haddad Maryam 
Published: August 2023

Background: Hepatocellular carcinoma (HCC) is the most common and aggressive type of liver cancer. Most chemotherapeutic medications nowadays imply oxidative stress leading to toxicity, which causes the necessity to find agents with better safety profiles against normal cells in addition to their anticancer activity. Sitagliptin has been shown to possess antioxidant as well as apoptotic properties by the specific suppression of dipeptidyl-peptidase 4, a glycoprotein produced in many tissues that have been thought to promote tumorigenesis and metastasis. Methods: Five groups of cell lines were included: Control (untreated HepG2 cells); cisplatin treatment HepG2 cells; sitagliptin treated HepG2 cells; combination of different concentrations of cisplatin plus sitagliptin (250 μg/mL) treated HepG2 cells, and finally, combination of different concentrations of sitagliptin plus cisplatin (25 μg/mL)-treated HepG2 cells. After an incubation period for 48 hours, the supernatants were collected to quantify the level malondialdehyde (MDA) and B-cell lymphoma-2 (BCL-2) by ELISA assay kits. Data were finally gathered and analyzed statistically. Results: Our findings indicated that sitagliptin significantly decreased the oxidative stress, particularly at high concentrations, through decreasing the MDA level. In addition, sitagliptin exhibited significant apoptotic activity against HepG2 cells through decreasing BCL-2 level. In combination with cisplatin, sitagliptin significantly potentiated the apoptotic effect and reduced the oxidative stress parameters. Conclusions: Sitagliptin showed apoptotic and antioxidant activity against HCC which may potentiate chemotherapeutic agents like cisplatin, in addition to reducing the oxidative stress against normal cells.
Enterprise resource planning implementation within science and technology park (STP) organisations: an avenue for future research. A systematic review.
Authors: Harun Sharbani , Dorasamy Magiswary , Bin Ahmad Abdul Aziz , Yap Ching Seng , Harguem Saida 
Published: August 2023

Background: Enterprise resource planning (ERP) is critical to enhancing the ability to control commercial activities and results in a competitive advantage when combined with an organisation's existing competitive advantages. However, our practise review reveals that end users resist ERP implementation because the resulting changes will alter the current status quo. The implementation of an ERP system in an organisation is complex as it affects multiple areas of the business. Resistance to change is cited as a factor of ERP failure. Methods: In this study, we conducted a systematic literature review using Transfield’s five stages and established a conceptual framework for ERP system implementation in science and technology parks (STPs). Articles collected from Emerald, Science Direct, ProQuest and Scopus databases between 1st June 2021 and 15th June 2021. Two authors were assigned to check the suitability of the articles in order to avoid risk of bias. Articles were analysed based on components of a research paper and the data was tabulated using MS Excel. Results: Only eight papers (0.011% of all the papers) appeared when we searched for papers related to ERP with a focus on post ERP Implementation, end-user behaviours, organisational performance, and the accelerated SAP (system application and product) methodology. We found that there are hardly any articles on ERP post implementations in STP context particularly based on the evaluation part of accelerated SAP. Conclusions: Results indicate the lack of studies in this field, particularly those addressing issues related to STP. This study attempted to broaden the understanding of the ERP's effectiveness, particularly in terms of an organisation's operational performance.