bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quadrupolar 23Na+ NMR relaxation as a probe of subpicosecond collective dynamics in aqueous electrolyte solutions
Authors: Chubak Iurii , Alon Leeor , Silletta Emilia V. , Madelin Guillaume , Jerschow Alexej , Rotenberg Benjamin 
Published: January 2023

AbstractNuclear magnetic resonance relaxometry represents a powerful tool for extracting dynamic information. Yet, obtaining links to molecular motion is challenging for many ions that relax through the quadrupolar mechanism, which is mediated by electric field gradient fluctuations and lacks a detailed microscopic description. For sodium ions in aqueous electrolytes, we combine ab initio calculations to account for electron cloud effects with classical molecular dynamics to sample long-time fluctuations, and obtain relaxation rates in good agreement with experiments over broad concentration and temperature ranges. We demonstrate that quadrupolar nuclear relaxation is sensitive to subpicosecond dynamics not captured by previous models based on water reorientation or cluster rotation. While ions affect the overall water retardation, experimental trends are mainly explained by dynamics in the first two solvation shells of sodium, which contain mostly water. This work thus paves the way to the quantitative understanding of quadrupolar relaxation in electrolyte and bioelectrolyte systems.
Enhanced chiroptic properties of nanocomposites of achiral plasmonic nanoparticles decorated with chiral dye-loaded micelles
Authors: Zhao Tonghan , Meng Dejing , Hu Zhijian , Sun Wenjing , Ji Yinglu , Han Jianlei , Jin Xue , Wu Xiaochun , Duan Pengfei 
Published: January 2023

AbstractThe development of circularly polarized luminescence (CPL)-active materials with both large luminescence dissymmetry factor (glum) and high emission efficiency continues to be a major challenge. Here, we present an approach to improve the overall CPL performance by integrating triplet-triplet annihilation-based photon upconversion (TTA-UC) with localized surface plasmon resonance. Dye-loaded chiral micelles possessing TTA-UC ability are designed and attached on the surface of achiral gold nanorods (AuNRs). The longitudinal and transversal resonance peaks of AuNRs overlap with the absorption and emission of dye-loaded chiral micelles, respectively. Typically, 43-fold amplification of glum value accompanied by 3-fold enhancement of upconversion are obtained simultaneously when Au@Ag nanorods are employed in the composites. More importantly, transient absorption spectra reveal a fast accumulation of spin-polarized triplet excitons in the composites. Therefore, the enhancement of chirality-induced spin polarization should be in charge of the amplification of glum value. Our design strategy suggests that combining plasmonic nanomaterials with chiral organic materials could aid in the development of chiroptical nanomaterials.
Gut colonisation with multidrug-resistant Klebsiella pneumoniae worsens Pseudomonas aeruginosa lung infection
Authors: Le Guern Rémi , Grandjean Teddy , Stabler Sarah , Bauduin Marvin , Gosset Philippe , Kipnis Éric , Dessein Rodrigue 
Published: January 2023

AbstractCarbapenemase-producing Enterobacterales (CPE) are spreading rapidly in hospital settings. Asymptomatic CPE gut colonisation may be associated with dysbiosis and gut-lung axis alterations, which could impact lung infection outcomes. In this study, in male C57BL/6JRj mice colonised by CPE, we characterise the resulting gut dysbiosis, and analyse the lung immune responses and outcomes of subsequent Pseudomonas aeruginosa lung infection. Asymptomatic gut colonisation by CPE leads to a specific gut dysbiosis and increases the severity of P. aeruginosa lung infection through lower numbers of alveolar macrophages and conventional dendritic cells. CPE-associated dysbiosis is characterised by a near disappearance of the Muribaculaceae family and lower levels of short-chain fatty acids. Faecal microbiota transplantation restores immune responses and outcomes of lung infection outcomes, demonstrating the involvement of CPE colonisation-induced gut dysbiosis in altering the immune gut-lung axis, possibly mediated by microbial metabolites such as short-chain fatty acids.
Scalable and robust quantum computing on qubit arrays with fixed coupling
Authors: Le N. H. , Cykiert M. , Ginossar E. 
Published: January 2023

AbstractWe propose a scheme for scalable and robust quantum computing on two-dimensional arrays of qubits with fixed longitudinal coupling. This opens the possibility for bypassing the device complexity associated with tunable couplers required in conventional quantum computing hardware. Our approach is based on driving a subarray of qubits such that the total multi-qubit Hamiltonian can be decomposed into a sum of commuting few-qubit blocks, and efficient optimisation of the unitary evolution within each block. The driving pulses are optimised to implement a target gate on the driven qubits, and at the same time identity gates on the neighbouring undriven qubits, cancelling any unwanted evolution due to the constant qubit-qubit interaction. We show that it is possible to realise a universal set of quantum gates with high fidelity on the basis blocks, and by shifting the driving pattern one can realise an arbitrary quantum circuit on the array. Allowing for imperfect Hamiltonian characterisation, we use robust optimal control to obtain fidelities around 99.99% despite 1% uncertainty in the qubit-qubit and drive-qubit couplings, and a detuning uncertainty at 0.1% of the qubit-qubit coupling strength. This robust feature is crucial for scaling up as parameter uncertainty is significant in large devices.
Trend of anticoagulant therapy in elderly patients with atrial fibrillation considering risks of cerebral infarction and bleeding
Authors: Tsuji Noriko , Takahashi Yoshimitsu , Sakai Michi , Ohtera Shosuke , Kaneyama Junji , Cho Kosai , Kato Genta , Ohtsuru Shigeru , Nakayama Takeo 
Published: January 2023

AbstractThe introduction of direct oral anticoagulants (DOACs) has greatly changed the use of anticoagulant therapy in patients with non-valvular atrial fibrillation (Af). Therefore, this study aimed to examine changes in the proportions of oral anticoagulant prescriptions in patients with non-valvular Af aged ≥ 65 years, taking into consideration the risk of cerebral infarction and bleeding. Anticoagulant prescriptions in outpatients aged ≥ 65 years with Af were temporally analyzed using the nationwide claims database in Japan. Trends in anticoagulant prescriptions were examined according to cerebral infarction and bleeding risk. The proportion of anticoagulant prescriptions for 12,076 Af patients increased from 41% in 2011 to 56% in 2015. An increase in DOAC prescriptions was accompanied by an increase in the proportion of anticoagulant prescriptions in each group according to the CHA2DS2-VASc and HAS-BLED scores. The proportion of anticoagulant prescriptions for patients with a high risk of developing cerebral infarction and bleeding showed a marked increase. Trends in anticoagulant prescriptions in Af patient with a CHA2DS2-VASc score ≥ 2 and HAS-BLED scores ≥ 3 showed a marked increase in DOAC prescriptions. The widespread use of DOACs greatly changes the profile the prescription of anticoagulant therapy in patients with Af.
Whole genome sequence characterization of Aspergillus terreus ATCC 20541 and genome comparison of the fungi A. terreus
Authors: Wu Hung-Yi , Mortensen Uffe Hasbro , Chang Fang-Rong , Tsai HsinYuan 
Published: January 2023

AbstractAspergillus terreus is well-known for lovastatin and itaconic acid production with biomedical and commercial importance. The mechanisms of metabolite formation have been extensively studied to improve their yield through genetic engineering. However, the combined repertoire of carbohydrate-active enzymes (CAZymes), cytochrome P450s (CYP) enzymes, and secondary metabolites (SMs) in the different A. terreus strains has not been well studied yet, especially with respect to the presence of biosynthetic gene clusters (BGCs). Here we present a 30 Mb whole genome sequence of A. terreus ATCC 20541 in which we predicted 10,410 protein-coding genes. We compared the CAZymes, CYPs enzyme, and SMs across eleven A. terreus strains, and the results indicate that all strains have rich pectin degradation enzyme and CYP52 families. The lovastatin BGC of lovI was linked with lovF in A. terreus ATCC 20541, and the phenomenon was not found in the other strains. A. terreus ATCC 20541 lacked a non-ribosomal peptide synthetase (AnaPS) participating in acetylaszonalenin production, which was a conserved protein in the ten other strains. Our results present a comprehensive analysis of CAZymes, CYPs enzyme, and SM diversities in A. terreus strains and will facilitate further research in the function of BGCs associated with valuable SMs.
Exploratory regression modeling for flood susceptibility mapping in the GIS environment
Authors: Fenglin Wang , Ahmad Imran , Zelenakova Martina , Fenta Assefa , Dar Mithas Ahmad , Teka Afera Halefom , Belew Amanuel Zewdu , Damtie Minwagaw , Berhan Marshet , Shafi Sebahadin Nasir 
Published: January 2023

AbstractUnderstanding the temporal and spatial patterns of flood in the Awash River basin, which is located in Ethiopia’s Afar region, is crucial. The Awash basin was picked because it is continuously in danger both spatially and temporally. The likelihood of flooding was assessed using eight independent variables: elevation, slope, rainfall, drainage density, land use, soil type, wetness index, and lineament density. Each constituent was assigned a weight based on its susceptibility to the danger, which was classified into four classifications. Exploratory regression analysis showed that the existing land use is the main factor influencing flood susceptibility. For the GIS domain, a total of 31 models were built using exploratory regression. Model number 31 was found to be the best fit model, having the highest Adjusted R2 value of 0.8 and the lowest Akaike’s Information criterion value of 1536.8. The spatial autocorrelation tool’s Z score and p-value for the standard residuals are, respectively, 0.7 and 0.4, indicating that they were neither clustered nor scattered. The geographic breadth of flood susceptibility and risk is thoroughly examined in this paper, as is the significance of spatial planning in the Awash basin.
A home-made pipette droplet microfluidics rapid prototyping and training kit for digital PCR, microorganism/cell encapsulation and controlled microgel synthesis
Authors: Chen Liao , Zhang Chenguang , Yadav Vivek , Wong Angela , Senapati Satyajyoti , Chang Hsueh-Chia 
Published: January 2023

AbstractDroplet microfluidics offers a platform from which new digital molecular assay, disease screening, wound healing and material synthesis technologies have been proposed. However, the current commercial droplet generation, assembly and imaging technologies are too expensive and rigid to permit rapid and broad-range tuning of droplet features/cargoes. This rapid prototyping bottleneck has limited further expansion of its application. Herein, an inexpensive home-made pipette droplet microfluidics kit is introduced. This kit includes elliptical pipette tips that can be fabricated with a simple DIY (Do-It-Yourself) tool, a unique tape-based or 3D printed shallow-center imaging chip that allows rapid monolayer droplet assembly/immobilization and imaging with a smart-phone camera or miniature microscope. The droplets are generated by manual or automatic pipetting without expensive and lab-bound microfluidic pumps. The droplet size and fluid viscosity/surface tension can be varied significantly because of our particular droplet generation, assembly and imaging designs. The versatility of this rapid prototyping kit is demonstrated with three representative applications that can benefit from a droplet microfluidic platform: (1) Droplets as microreactors for PCR reaction with reverse transcription to detect and quantify target RNAs. (2) Droplets as microcompartments for spirulina culturing and the optical color/turbidity changes in droplets with spirulina confirm successful photosynthetic culturing. (3) Droplets as templates/molds for controlled synthesis of gold-capped polyacrylamide/gold composite Janus microgels. The easily fabricated and user-friendly portable kit is hence ideally suited for design, training and educational labs.
Investigation of structural and neurobiochemical differences in brains from high-performance and native hen breeds
Authors: Kasperek Kornel , Jaworska-Adamu Jadwiga , Krawczyk Aleksandra , Rycerz Karol , Buszewicz Grzegorz , Przygodzka Dominika , Wójcik Grzegorz , Blicharska Eliza , Drabik Kamil , Czech Anna , Wlazło Łukasz , Ossowski Mateusz , Rozempolska-Rucińska Iwona 
Published: January 2023

AbstractSelection of livestock has not only led to changes in the level of their performance but also modified their behavior. As a result, within a single species, we have to deal with different behaviors of different breeds. In our study, we assumed that the different behaviors within a species are due to differences in the morphology and physiology of behavior-related systems. Two breeds of hens were used as a model: the highly reactive, fearful and high-performance Leghorn breed and proactive, unselected Green-legged Partridge breed. The higher reactivity and fearfulness of Leghorn hens in comparison to the Green-legged Partridge breed may be related to the greater number of neurons in the paraventricular nucleus and anterior hypothalamus and the higher content of zinc and iron in the brain, as these elements are involved in neuronal conduction and myelination processes. The reactive behaviours of Green-legged Partridge hens may be associated with the lower number of neurons in the paraventricular nucleus and the anterior hypothalamus and the higher concentration of dopamine and copper ions in the brain. The analyses confirmed the hypothesis of the existence of interbreed differences in the morphology and physiology of behaviour-related systems, which most probably emerged through unintentional and correlated selection towards high production performance. Consequently, attention should be drawn that the selection of a given genotype (breed) towards a specific environment could lead to creation of highly specialised lines that may not achieve homeostasis in every maintenance system.
Finger vein recognition based on bilinear fusion of multiscale features
Authors: Ma Bin , Wang Kaixuan , Hu Yueli 
Published: January 2023

AbstractFinger veins are widely used in various fields due to their high safety. Existing finger vein recognition methods have some shortcomings, such as low recognition accuracy and large model size. To address these shortcomings, a multi-scale feature bilinear fusion network (MSFBF-Net) was designed. First, the network model extracts the global features and local detail features of the finger veins and performs linear fusion to obtain second-order features with richer information. Then, the mixed depthwise separable convolution replaces the ordinary convolution, which greatly reduces the computational complexity of the network model. Finally, a multiple attention mechanism (MAM) suitable for finger veins was designed, which can simultaneously extract the channel, spatial, directional, and positional information. The experimental results show that the method is very effective, and the accuracy of the two public finger vein databases is 99.90% and 99.82%, respectively.
Different impact on health outcomes of long-term care insurance between urban and rural older residents in China
Authors: Liu Paicheng , Yang Youlang , Yang Yuxuan , Cheng Jianxin 
Published: January 2023

AbstractLong-term care insurance (LTCI) is garnering attention internationally and is being considered a public policy in a growing number of countries. Previous research has focused on the effects of LTCI in developed countries, ignoring the health outcomes of developing countries, especially in rural regions. Therefore, this study investigates whether different impact on health outcomes is present in the effects of LTCI between urban and rural residents in China. We employed a quasi-experimental design with data from the China Health and Retirement Longitudinal Survey. The specific implementation time of each pilot city was sorted according to the LTCI policy texts, dividing these pilot cities into the treatment group and control group. Finally, difference-in-differences analyses were utilized to evaluate the health effects of LTCI between urban and rural residents, and the health effect in urban areas was further tested. The implementation of LTCI has effectively enhanced the self-rating health (SRH) of the entire group of residents; however, this effect may only be significant for the urban group. In particular, LTCI can increase the SRH of urban residents by 0.377 units compared to the urban residents without LTCI (P < 0.01). The result of the placebo effect test further verifies that LTCI could improve the health of residents to some extent. In China, LTCI may have triggered different impacts on health outcomes between urban and rural residents, and may not improve the SRH of rural residents and only prove efficacious for urban residents. Government and policy-makers should give more attention to the rural group as it needs long-term care the most.
Next-generation applications for integrated perovskite solar cells
Authors: Bati Abdulaziz S. R. , Zhong Yu Lin , Burn Paul L. , Nazeeruddin Mohammad Khaja , Shaw Paul E. , Batmunkh Munkhbayar 
Published: January 2023

AbstractOrganic/inorganic metal halide perovskites attract substantial attention as key materials for next-generation photovoltaic technologies due to their potential for low cost, high performance, and solution processability. The unique properties of perovskites and the rapid advances that have been made in solar cell performance have facilitated their integration into a broad range of practical applications, including tandem solar cells, building-integrated photovoltaics, space applications, integration with batteries and supercapacitors for energy storage systems, and photovoltaic-driven catalysis. In this Review, we outline notable achievements that have been made in these photovoltaic-integrated technologies. Outstanding challenges and future perspectives for the development of these fields and potential next-generation applications are discussed.
A topographic hinge-zone divides coastal and inland ice dynamic regimes in East Antarctica
Authors: Andersen Jane L. , Newall Jennifer C. , Fredin Ola , Glasser Neil F. , Lifton Nathaniel A. , Stuart Finlay M. , Fabel Derek , Caffee Marc , Pedersen Vivi K. , Koester Alexandria J. , Suganuma Yusuke , Harbor Jonathan M. , Stroeven Arjen P. 
Published: January 2023

AbstractThe impact of late Cenozoic climate on the East Antarctic Ice Sheet is uncertain. Poorly constrained patterns of relative ice thinning and thickening impair the reconstruction of past ice-sheet dynamics and global sea-level budgets. Here we quantify long-term ice cover of mountains protruding the ice-sheet surface in western Dronning Maud Land, using cosmogenic Chlorine-36, Aluminium-26, Beryllium-10, and Neon-21 from bedrock in an inverse modeling approach. We find that near-coastal sites experienced ice burial up to 75–97% of time since 1 Ma, while interior sites only experienced brief periods of ice burial, generally <20% of time since 1 Ma. Based on these results, we suggest that the escarpment in Dronning Maud Land acts as a hinge-zone, where ice-dynamic changes driven by grounding-line migration are attenuated inland from the coastal portions of the East Antarctic Ice Sheet, and where precipitation-controlled ice-thickness variations on the polar plateau taper off towards the coast.
The Effects of Abutment Finish Lines on the Penetration Characteristics of Elastomers into the Simulated Gingival Sulcus
Authors: Jaroenpiboon Atiwat , Apinsathanon Pongsakorn , Na Nan Pheeradej , Aimjirakul Napapa 
Published: January 2023

Abstract
Objective The aim of this study was to determine the effect of finish lines on the penetration ability of polyether and polyvinyl siloxane impression material into the simulated gingival sulcus.
Materials and Methods Three types of finish line (chamfer, deep chamfer, and radial shoulder) were impressed with two types of elastomeric impression material (polyether and polyvinyl siloxane) using a two-step impression technique. Ten samples of each finish line were prepared and then separated into two groups of impression material: polyether and polyvinyl siloxane. The model of the simulated gingival sulcus had a width of 0.1 mm and a depth of 3.5 mm with a subgingival finish line of 0.5 mm. The effect of the finish lines on the penetration ability of these impression materials was analyzed using a two-way analysis of variance (ANOVA) and Tukey's multiple comparison tests at a statistically significant level of 0.05.
Results A two-way ANOVA revealed a significant difference among finish lines, impression materials, and their interaction. The deep chamfer and radial shoulder finish lines displayed significantly higher penetration ability than the chamfer finish line. Moreover, polyether revealed significantly higher penetration ability than polyvinyl siloxane.
Conclusion The finish lines affected the penetration ability of the impression materials. Therefore, the simulated gingival sulcus model demonstrates that it is an effective way of examining impression materials' penetration abilities.
Pharmaceutical pollution in marine waters and benthic flora of the southern Australian coastline
Authors: Long Benjamin M. , Harriage Samantha , Schultz Nick L. , Sherman Craig D. H. , Thomas Michael 
Published: January 2023

Environmental context Most human pharmaceutical waste is discharged to the environment. While the presence of pharmaceuticals in freshwater systems is well documented globally, little is known of the impact on marine ecosystems. We measured pharmaceuticals in a marine environment in south-eastern Australia and found pharmaceutical concentrations around 24 000 times higher in benthic flora than in the marine surface waters. We discuss the potential use of seaweeds as biological indicators of pharmaceutical pollution. Rationale Pharmaceuticals are emerging pollutants of concern with a range of adverse consequences for organisms and ecosystems. Their presence in freshwater and estuarine systems has been well documented, but less is known about their prevalence in open ocean, or their uptake by benthic flora. This preliminary survey of the southern Australian coastline sought to measure the concentrations of key pharmaceuticals in both surface waters and benthic flora. Methodology This study used LC-MS/MS to measure the concentration carbamazepine, tramadol and venlafaxine in (1) samples from wastewater treatment plants, (2) ocean surface waters and (3) several species of benthic flora. Surface waters and benthic flora were sampled at two sites near waste water treatment plant (WWTP) discharges, and one site away from any discharge. Results All three pharmaceuticals were detected in surface water samples with their risk assessed (via risk quotient) as medium risk (carbamazepine) or low risk (venlafaxine, tramadol). All three pharmaceuticals were also detected in benthic flora, particularly in brown macroalgae; Tramadol was measured at a maximum of 34.7 ng g−1 in Hormosira banksii, and Venlafaxine was recorded at a maximum of 17.3 ng g−1 in Caulocystis cephalornithos. Discussion The calculated bioconcentration factors suggest the pharmaceutical concentrations in benthic flora were up to ~24 000 times higher than in surrounding surface water. There was also evidence that proximity to WWTP outfalls influenced the levels of pharmaceuticals in benthic flora. The results suggest that the benthic flora may be suitable bioindicators of pharmaceutical contamination and that the potential impacts of pharmaceutical pollutants in marine ecosystems demand further investigation.