bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel CAD/CAM-splint-based navigation protocol enhances intraoperative maxillary position control in orthognathic surgery: a case control study
Authors: Schrader Felix , Saigo Leonardo , Kübler Norbert , Rana Majeed , Wilkat Max 
Published: January 2025

Abstract
Background
Virtual surgical planning for orthognathic surgery typically relies on two methods for intraoperative plan transfer: CAD/CAM occlusal splints and patient-specific implants (PSI). While CAD/CAM splints may offer limited accuracy, particularly in the vertical dimension, PSIs are constrained by higher costs and extended preparation times. Surgical navigation has emerged as a potential alternative, but existing protocols often involve invasive registration or lack transparent evaluation. This study introduces a novel protocol for point-based optical navigation using modified CAD/CAM splints for non-invasive registration and transparent intraoperative evaluation, assessing its effectiveness in maxillary positioning.

Methods
This prospective case-control study included 20 patients undergoing bimaxillary orthognathic surgery. The experimental group employed surgical navigation with modified CAD/CAM splints, while the control group used standard CAD/CAM splints. Surgical accuracy was evaluated by measuring translational and rotational discrepancies between the planned and achieved maxillary positions. A mixed ANOVA was conducted to assess other factors, aside from surgical navigation, that might influence surgical accuracy.

Results
Surgical navigation significantly improved accuracy in translational movements along the x-axis (right-left: -0.81 mm; p = 0.021) and z-axis (down-up: -0.82 mm; p = 0.014), as well as in yaw rotation (-0.45°; p = 0.045). Other movements also showed improved precision in the navigated group, though not statistically significant; y-axis (back-front): -0.60 mm (p = 0.094); pitch rotation: -0.70° (p = 0.071); roll rotation: -0.04° (p = 0.428). Besides the use of surgical navigation, the amount of planned movement significantly impacted surgical accuracy, although no specific factors could be identified to predict which cases would particularly benefit from surgical navigation.

Conclusions
Surgical navigation with modified CAD/CAM splints enhances surgical accuracy without requiring invasive procedures, offering a straightforward and transparent protocol suitable for routine clinical practice that allows intraoperative evaluation of maxillary positioning. However, the clinical significance and cost-effectiveness compared to PSI need further investigation. These findings suggest new directions for future developments, especially with advancements in mixed reality technologies, which could broaden the application of surgical navigation.

Trial registration
Retrospectively registered with the German Clinical Trials Register (DRKS00034795).
Decreased attenuation difference between non-contrast and portal-venous phases of CT predicts the ultrasonography-unspecified adnexal torsion
Authors: Xie Weili , Huang Zhongren , Kuang Hongmei , Li Xiaoxing , Zhang Rixin , Zeng Wei , Jin Cheng , Zhong Junyuan , Peng Jidong , Cheng Weiling , Zhou Fuqing 
Published: January 2025

Abstract
Objectives
To evaluate the value of contrast-enhanced CT in diagnosing ultrasonography-unspecified adnexal torsion (AT).

Methods
Surgically confirmed patients with painful pelvic masses (n = 165) were retrospectively collected from two institutes. Two senior radiologists independently reviewed the CT images and determined the Hounsfield unit difference between non-contrast vs portal venous phases (ΔHUPV-NC) in both derivation and validation samples. The cutoff value, sensitivity, specificity, predictivity, and reproducibility of the ΔHUPV-NC and other visually assessed CT signs were analyzed and compared using the receiver-operating characteristic curve, multivariable regression, and inter-rater agreement assays, respectively.

Results
Women with twisted (n = 73 [47 ± 19 years]) or untwisted (n = 92 [40 ± 15 years]) adnexal lesions were reviewed. The ΔHUPV-NC ≤ 17.5 HU (AUC: 0.91 [95% CI: 0.86, 0.96]; sensitivity: 95% [95% CI: 87, 98]; and specificity: 88% [95% CI: 80, 94]) was the independent predictor of AT (OR: 137 [95% CI: 39, 481], p < 0.001). After training in ΔHUPV-NC measurement, the agreement between two junior residents and the consensus increased from fair (resident-1: 0.29 [95% CI: 0.17, 0.41]; resident-2: 0.24 [95% CI: 0.1, 0.39]) to substantial (resident-1: 0.75 [95% CI: 0.65, 0.85]; resident-2: 0.72 [95% CI: 0.62, 0.83]). The post-training diagnostic accuracy (both residents: 81% [95% CI: 74, 87]) was higher than the pre-training accuracy (resident-1: 67% [95% CI: 59, 74], p = 0.007; resident-2: 66% [95% CI: 58, 73], p = 0.002).

Conclusion
The sign of ΔHUPV-NC ≤ 17.5 HU in contrast-enhanced CT can be used to predict the ultrasonography-unspecified AT.

Critical relevance statement
The decreased attenuation difference between non-contrast vs portal venous phases, a quantitative measurement-based CT sign, highlights the value of using contrast-enhanced CT as a second-line imaging approach after an equivocal ultrasonographic examination to diagnose AT in emergency settings.

Key Points

The value of contrast-enhanced CT in diagnosing ultrasonography-unspecified AT is underestimated.

The ΔHUPV-NC ≤ 17.5 HU is the only predictor to diagnose the ultrasonography-unspecified AT.

Contrast-enhanced CT can be used as a second-line imaging approach after an equivocal ultrasonographic examination.

Graphical Abstract
Efficacy of bolus injections of landiolol hydrochloride as premedication in coronary artery CT angiography
Authors: Barwig Mark , Janisch Michael , Gessl Johannes , Kübler Wolfgang , König Christopher , Schwantzer Gerold , Schöllnast Helmut 
Published: January 2025

Abstract
Purpose
To assess the efficacy of bolus injections of landiolol hydrochloride as premedication in coronary artery CT angiography (CCTA).

Methods
The study population consisted of 37 patients (17 female; median age, 56 years; IQR, 19 years; range, 19–88 years) who underwent CCTA after intravenous injection of landiolol hydrochloride due to a heart rate > 60 bpm. Landiolol hydrochloride was administered in a stepwise manner until a heart rate of ≤ 60 bpm was achieved or a maximum dose of 60 mg was reached after six injections. Heart rates routinely displayed continuously on the CT scanner before the start of the landiolol hydrochloride injection (HRPRE), after each partial dose (HR1–6), during the CT scan (HRCT), and after the examination before moving from the CT table (HRPOST) were recorded. Furthermore, the blood pressure routinely measured before (BPPRE) and after the examination before moving from the CT table (BPPOST) was recorded.

Results
A HRCT of ≤ 60 bpm was achieved in 13 patients (35%) and a HRCT ≤ 65 bpm was achieved in 25 patients (68%). The mean difference (± SD) between HRPRE and HRCT was −11 ± 9 bpm in total, −14 ± 10 bpm in patients without oral beta-blocker premedication and −6 ± 5 bpm in patients with oral Beta-blocker premedication.

Conclusions
Landiolol hydrochloride enables a reduction of the heart rate in patients with and without oral beta-blocker premedication, whereby the use of serial partial doses is a simple and effective approach in clinical routine.

Critical relevance statement
In cardiac CT, weight-independent, stepwise landiolol hydrochloride injection up to 40 mg reduces heart rate by −14 bpm without and −5 bpm with oral beta-blocker premedication, and achieves heart rates of ≤ 65 bpm in a significant proportion of patients.

Key Points

The ideal heart rate for cardiac CT is ≤ 60–65 bpm, which improves image quality and reduces radiation dose.

In cardiac CT, landiolol hydrochloride intravenously reduces heart rate by −14 bpm.

Heart rate of ≤ 65 bpm can be achieved in a significant proportion of patients.

Graphical Abstract
Painful vision loss during air travel after vitrectomy with air tamponade: a case report
Authors: Emrich Jessica , Charbel Issa Peter , Baumann Carmen 
Published: January 2025

Abstract
Background
While the potentially hazardous effects of intraocular perfluorocarbon gases during air travel have been recognized, the equivalent risk of intraocular air tamponade is less known and has, to the best of our knowledge, not been reported yet.

Case presentation
A 52-year-old white female experienced a complete loss of vision and pain in her left eye during air travel following pars plana vitrectomy with air tamponade. Clinical and multimodal imaging findings only a few hours after emergency landing indicated a transient central retinal artery occlusion due to a significant increase in intraocular pressure during the flight.

Conclusion
Air travel, even with a relatively small volume of residual air tamponade, can lead to potentially serious complications.
Long-term effects of linear versus macrocyclic GBCAs on gene expression in the central nervous system of mice
Authors: Wang Chuanbing , Tang Yuxia , Tang Jiajia , Zhang Jie , Wang Siqi , Wu Feiyun , Wang Shouju 
Published: January 2025

Abstract
Background
We examined chronic gadolinium retention impact on gene expression in the mouse central nervous system (CNS) after injection of linear or macrocyclic gadolinium-based contrast agents (GBCAs).

Methods
From 05/2022 to 07/2023, 36 female mice underwent weekly intraperitoneal injections of gadodiamide (2.5 mmol/kg, linear), gadobutrol (2.5 mmol/kg, macrocyclic), or saline. Mice were sacrificed on day 29 or 391 after a 1-year washout. Assessments included magnetic resonance imaging (MRI), mechanical hyperalgesia tests, and inductively coupled plasma mass spectrometry to measure gadolinium levels. Ribonucleic acid (RNA) sequencing and bioinformatic analyses identified differentially expressed genes (DEGs), with validation by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot (WB).

Results
Post-gadodiamide, MRI showed increased signal intensity in the deep cerebellar nuclei (pre, 0.997 ± 0.006 versus post, 1.086 ± 0.013, p < 0.001). Mechanical hyperalgesia tests indicated transient sensory changes. After 1-year, gadolinium retention was noted in the brain (5.92 ± 0.32 nmol/kg) and spinal cord (1.23 ± 0.66 nmol/kg) with gadodiamide, compared to saline controls (0.06 ± 0.02 nmol/kg in brains and 0.28 ± 0.06 nmol/kg in spinal cords). RNA sequencing identified 17 shared DEGs between brain and spinal cord in the gadodiamide group on day 391, with altered Hmgb2 and Sgk1 expression confirmed by qRT-PCR and WB. Reactome pathway analysis showed enrichment in neuroinflammation pathways. No DEGs were detected in brains on day 29.

Conclusion
Chronic gadolinium deposition from repeated linear GBCA but not macrocyclic administration causes significant gene expression alterations in the mouse CNS, particularly affecting neuroinflammation pathways.

Relevance statement
This study examined the long-term impact of chronic gadolinium retention on gene expression in the mouse CNS, uncovering significant changes associated with neuroinflammation pathways after repeated administration of linear GBCA, but not with macrocyclic GBCA. These findings highlight the importance of further research on the long-term safety of linear GBCA in medical imaging.

Key Points

Chronic gadolinium retention alters gene expression in the mouse central nervous system.

Significant neuroinflammatory pathway changes were observed after linear gadodiamide exposure.

MRI showed increased signal intensity in deep cerebellar nuclei after gadodiamide injection.

Graphical Abstract
Performance enhancement of gas cyclone with streamlined ports using CFD simulations
Authors: Soliman Moustafa M. , El-shaer Yasser , Elsayed Khairy , Ibrahim Mohamed A. 
Published: January 2025

AbstractCyclones are extensively utilized as gas-solid separators in many industries such as pharmaceuticals, food processing, and powder handling often use mini cyclones for efficient dust collection, air filtration, and contaminant separation in compact systems. The impact of the cyclone vortex finder (VF) diameter, the VF inlet bell mouth shape, and the VF inlet curvature on both flow field distribution and performance has been analyzed through computational analysis employing the Reynolds stress turbulence model (RSM) for twelve cyclone separators. The results demonstrate that decreasing the diameter of the VF by 33% elevates the ultimate tangential velocity by 66%. The ultimate tangential velocity nearly reaches four times the inlet velocity. A reduction of 14% in the VF inlet curvature results in a 6% enlarging in the pressure loss.Enhancing the bell mouth configuration of the inlet VF by 25% decreases the maximum pressure by 3.7%. Increasing the diameter of the VF, the VF inlet curvature, and the VF inlet bell mouth shape will also lead to reduced $${x}_{50}$$

x
50

. The cyclone with no curvature exhibits lower pressure and tangential velocity compared to the cyclones with curvature and radius of bell mouth shape of (DX/D) ratio equal 0.5. However, all the three cyclones have the same ratio. Cyclones A0 and C1 have the highest collection efficiency of all cyclone models.
Place of death and healthcare utilisation at the end of life among individuals with mental and behavioural disorders as underlying cause of death: population-level multiple-register study
Authors: Olsson Maja Magdalena , Holmberg Christopher , Larsdotter Cecilia , Nyblom Stina , Öhlén Joakim 
Published: January 2025

Background
Understanding the place of death for individuals with mental and behavioural disorders (MBDs) is essential for identifying disparities in healthcare access and outcomes, as well as addressing broader health inequities within this population.

Aims
To examine the place of death among individuals in Sweden with the underlying cause of death reported as a MBD and compare variations between diagnostic groups, as well as explore associations between place of death and individual, sociodemographic and clinical factors.

Method
This population-level analysis used death certificate data (gender, age, underlying cause of death and place of death) recorded between 2013 and 2019 and other national register data. MBD group differences were compared using chi-square tests (χ2) and multinominal logistic regressions explored variations in place of death.

Results
The final sample consisted of 2875 individuals. Our regression model revealed that individuals with MBDs other than intellectual disabilities were less likely to die in hospitals (odds ratio 0.60–0.134 [95% CI = 0.014–0.651]) or care homes (odds ratio 0.11–0.97 [95% CI = 0.003–0.355]) than at home. Substance use disorders were the most common underlying cause of death (61.3%). This group consisted predominantly of men (78.8%, χ2, P < 0.001), and tended to be younger (χ2, P < 0.001).

Conclusions
Individuals with intellectual and developmental disabilities are more likely to die in hospitals or care homes than at home. Those with MBDs, particularly substance use disorders, face a high risk of premature death, highlighting gaps in healthcare and palliative care provision for these populations.
Unearthing Zombies
Authors: Kulkarni Nirupama , Ritadhi S. K. , Vij Siddharth , Waldock Katherine 
Published: January 2025

Bankruptcy reforms that improve lenders’ ability to recover claims from financially distressed borrowers can mitigate zombie lending. However, we show that after a 2016 bankruptcy reform in India, lenders are reluctant to recognize zombie credit as nonperforming, impeding reform efficacy. A subsequent complementary regulation targeting lender discretion in recognizing nonperforming assets improves zombie recognition fivefold. The lender disincentive to recognize zombies arises from undercapitalized banks’ reluctance to realize loan losses and political economy frictions at state-owned banks. Resolving zombie credit allows lenders to redirect credit to healthy borrowers, but effects are muted at banks more exposed to zombie borrowers. This paper was accepted by Victoria Ivashina, finance. Funding: The authors are grateful for financial support provided by the NSE-NYU Stern Initiative on the Study of Indian Capital Markets. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01356 .
On Interim Envy-Free Allocation Lotteries
Authors: Caragiannis Ioannis , Kanellopoulos Panagiotis , Kyropoulou Maria 
Published: January 2025

With very few exceptions, recent research in fair division has mostly focused on deterministic allocations. Deviating from this trend, we study the fairness notion of interim envy-freeness (iEF) for lotteries over allocations, which serves as a sweet spot between the too-stringent notion of ex post envy-freeness and the very weak notion of ex ante envy-freeness. Our analysis relates iEF to other fairness notions as well and reveals trade-offs between iEF and efficiency. Even though several of our results apply to general fair division problems, we are particularly interested in instances with equal numbers of agents and items where allocations are perfect matchings of the items to the agents. We show how to compute iEF allocations in matching allocation instances in polynomial time while also maximizing several efficiency objectives, even though this proves to be considerably more challenging than computing envy-free allocations. Our algorithms use efficient solutions to a novel variant of the bipartite matching problem. We also study the extension of iEF when payments to or from the agents are allowed. We present a series of results on two optimization problems, including a generalization of the classical rent division problem to random allocations. Funding: I. Caragiannis was partially supported by Danmarks Frie Forskningsfond [Grant 032-00185B].
Characteristics of six cherry tomato genotypes as genetic material for plant breeding programs
Authors: WAHYUDI ANUNG , HAKIM NURMAN ABDUL , RACHMAN MICHO SANDEKA 
Published: January 2025

Abstract. Wahyudi A, Hakim NA, Rachman MS. 2024. Characteristics of six cherry tomato genotypes as genetic material for plant breeding programs. Biodiversitas 25: 3850-3859. The morphological characteristics of tomato plants (Solanum lycopersicum L.) are a source of genetic variation in efforts to improve the quality of tomatoes in plant breeding programs. Breeding programs focus on developing genotypes with high fruit set and yield potential. Cherry tomatoes are often selected for their prolific fruiting capabilities. This study aimed to determine the morphological characteristics of six cherry tomato plant varieties. This study used a Randomized Block Design (RBD) comprising four introduced hybrid cherry tomato varieties from Japan (Chika, Chou Amai, Premium Ruby, and Aiko) with two commercial hybrid varieties from PT. Bintang Asia (Citra Asia F1 and Rempai), each with three replications. Data were analyzed using analysis of variance (ANOVA) at a 5% significance level, and orthogonal contrast analysis was adopted for mean value testing. Observations of qualitative characteristics were conducted from the vegetative phase through post-harvest. The results showed that Japanese-introduced tomatoes were superior in fruit length, sweetness, and number of fruits per plant. Meanwhile, the Chika tomato variety was superior in the number of leaves under the first bunch (8.67), weight of 10 fruits (280 g), fruit width (3.75 cm), and flesh thickness (0.45 cm). The Premium Ruby variety was superior in fruit sweetness (7.9 ºbrix) and in harvest age (64 DAT). In comparison, the Aiko variety showed superiority in bunch length (22.57 cm) and number of fruits per plant (238.33). The characteristics of introduced hybrid cherry tomato varieties from Japan can be used as material for assembling new cultivars. These findings have direct implications for increasing tomato productivity in Indonesia, providing valuable insights for future breeding programs.
Patterns of belatacept use and risk of post-transplant lymphoproliferative disorder in US kidney transplant recipients: An analysis of the Organ Procurement and Transplantation Network database
Authors: Cherikh Wida S. , Kou Tzuyung Douglas , Foutz Julia , Baker Timothy J. , Gomez-Caminero Andres 
Published: January 2025

Background
Belatacept is approved for the prophylaxis of organ rejection in Epstein-Barr virus (EBV)-seropositive kidney transplant recipients and is associated with a risk of post-transplant lymphoproliferative disorder (PTLD).

Methods
Data from the Organ Procurement and Transplantation Network were used to examine patterns of belatacept use, describe patient characteristics, and estimate risk of PTLD in EBV-seropositive, kidney-only transplant recipients receiving belatacept- or calcineurin inhibitor (CNI)-based immunosuppression as part of US Food and Drug Administration-mandated safety monitoring.

Results
During the study period (June 15, 2011–June 14, 2016), 94.9% (1631/1719) of belatacept-treated and 89.7% (59,992/66,905) of CNI-treated patients with known EBV serostatus were EBV seropositive. Among EBV-seropositive patients, 50.2% (belatacept) and 56.8% (CNI) received a standard criteria donor kidney, 59.5% and 18.7% received basiliximab induction, and 22.9% and 50.8% received antithymocyte globulin induction. PTLD developed in nine belatacept-treated patients (two with central nervous system [CNS] involvement) and 225 CNI-treated patients (nine with CNS involvement). Four and 81 patients, respectively, died due to PTLD. Kaplan–Meier analysis did not show a significant between-group difference in PTLD estimated incidence rates within 5 years (0.70% versus 0.48%, respectively; p = 0.18). Additionally, estimated PTLD incidence was not significantly different between treatment groups in a propensity score matched cohort.

Conclusions
The majority of adult kidney-only transplant recipients treated with belatacept in routine clinical practice are EBV seropositive. In this study, the risk of PTLD in these patients, while higher than for CNI-based immunosuppression, remained low after adjusting for differences in patient characteristics.

Trial registration
These studies are registered at ClinicalTrials.gov: NCT01670058 and NCT01656343.