bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-line management of necrotizing herpetic retinitis by prioritizing the investigation of immune status and prognostic factors for poor visual outcomes
Authors: Loubsens Emmanuelle , Adam Raphaël , Debard Alexa , Barioulet Lisa , Varenne Fanny , Fournié Pierre , Sales de Gauzy Thomas , Ollé Priscille , Martin-Blondel Guillaume , Soler Vincent 
Published: March 2023

Abstract
Purpose
To review management, treatment, and outcomes of patients with necrotizing herpetic retinitis (NHR) to propose an algorithm for first-line management of NHR.

Methods
Retrospective evaluation of a series of patients with NHR at our tertiary center between 2012 and 2021 using demographic, clinical, ophthalmologic, virological, therapeutic, and prognostic characteristics was performed. Patients were classified by NHR type: acute retinal necrosis (ARN), progressive outer retinal necrosis (PORN), cytomegalovirus (CMV) retinitis.

Results
Forty-one patients with NHR were included: 59% with ARN, 7% with PORN, and 34% with CMV retinitis. All patients with CMV retinitis and PORN were immunocompromised versus 21% of patients with ARN. CMV infection was found in 14 (34%) patients, varicella zoster virus infection in 14 (34%) patients, herpes simplex virus type 2 infection in 8 (20%) and type 1 infection in 5 (12%) patients. Intravenous antiviral therapy was received by 98% of patients and intravitreal antiviral injections by 90% of patients. The overall complication rate during follow-up was 83% of eyes. Most frequent complications were retinal detachment (33% eyes) and retinal break (29% eyes). Prognostic factors for poor visual outcomes were pre-existing monocular vision loss in contralateral eye among 17% of patients, bilateral NHR in 17% of patients, posterior pole involvement in 46% of eyes, and involvement > 2 retinal quadrants in 46% of eyes.

Conclusions
The visual prognosis of patients with NHR remains poor. Prompt investigation of immune status and presence of factors justifying intravitreal antiviral injections must be prioritized to initiate and adapt management while awaiting causative virus confirmation.
Influence of wood pretreatment, hardwood and softwood extractives on the compressive strength of fly ash-based geopolymer composite
Authors: Asante Bright , Appelt Jörn , Yan Libo , Krause Andreas 
Published: March 2023

AbstractThis paper investigated the specific compressive strength (specific strength) of fly ash-based geopolymer composites with four hardwood extractives and two softwood extractives, as well as specific wood extractives. Additionally, the effect of the portion of pine wood (i.e., sapwood and heartwood) and wood pretreatment with NaOH were considered. Geopolymer paste (with extractives) and geopolymer wood composites (GWCs) were cured at 60 °C for 24 h. The samples were stored in a climate chamber (20 °C, 65% RH) for 7 days before finally testing under compression. From the results, the specific strengths of geopolymers with hardwood extractives were not significantly affected. However, geopolymers containing pine extractives showed the most significant reduction in specific strength. There were no significant differences in the specific strengths of geopolymers containing polyphenols and resin acid. Generally, geopolymers containing fatty acids recorded the lowest specific strengths. There was no difference between the GWCs with untreated sapwood and heartwood. However, the wood pretreatment led to a 21% and 10% increase in the specific strengths of GWCs with sapwood and heartwood, respectively. The findings of this study form the basis for improved GWCs production and a wide range of applications for green composite materials.
Comparative RNA-sequencing analysis of the prostate in a mouse model of benign prostatic hyperplasia with bladder outlet obstruction
Authors: Tang Xiaohu , Liu Zhiyan , Ren Jingwen , Cao Ying , Xia Shujie , Sun Zhaolin , Luo Guangheng 
Published: March 2023

AbstractIn ageing men, benign prostatic hyperplasia (BPH) is a chronic disease that leads to progressive lower urinary tract symptoms (LUTS) caused by obstruction of the bladder outlet (BOO). Patients with LUTS (such as increased frequency and urgency of urination) and complications of BOO (such as hydronephrosis and bladder stones) are at risk of serious health problems. BPH causes a rapidly rising burden of LUTS far exceeding that of other urological conditions. Treatment outcomes are unsatisfactory for BPH largely due to the lacking of fully understanding of the pathogenesis. Hormonal imbalances related to androgen and oestrogen can cause BPH, but the exact mechanism is still unknown, even the animal model is not fully understood. Additionally, there are no large-scale data to explain this mechanism. A BPH mouse model was established using mixed slow-release pellets of testosterone (T) and estradiol (E2), and we measured gene expression in mouse prostate tissue using RNA-seq, verified the results using qRT‒PCR, and used bioinformatics methods to analyse the differentially expressed genes (DEGs).
Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells
Authors: Ferreira Filipa P. , Pereira Sofia S. , Costa Madalena M. , Guimarães Marta , Albrechtsen Nicolai J. Wewer , Holst Jens J. , Nora Mário , Monteiro Mariana P. 
Published: March 2023

AbstractNeurotensin (NT) is a gastro-intestinal hormone involved in several pathways that regulate energy and glucose homeostasis. NT was hypothesized to act in synergy with incretin hormones to potentiate its anti-diabetic effects. Additionally, circulating NT levels were shown to rise after bariatric surgery-induced weight loss. Knowledge of NT-secreting cells distribution along the small intestine and its variation according to diabetes status could provide insights on NT role in mediating type 2 diabetes (T2D) improvement after bariatric surgery. So, our aims were to characterize NT-expressing cell distribution along the human small intestine and to compare the relative density of NT-expressing cells in the small intestine of individuals with and without T2D undergoing bariatric surgery for obesity treatment. Autopsy-derived small intestine fragments (n = 30) were obtained at every 20 cm along the entire intestinal length. Additionally, jejunum biopsies (n = 29) were obtained during elective gastric bypass interventions from patients with (n = 10) or without T2D (n = 18). NT-expressing cells were identified by immunohistochemistry and quantified via computerized morphometric analysis. NT-expressing cell density increased along the human small intestine. NT-expressing cell density was significantly higher from 200 cm distal to the duodenojejunal flexure onward, as well as in subjects with T2D when compared to those without T2D. NT-expressing cell density increases along the human small gut, and a higher density is found in individuals with T2D. This finding suggests a potential role for NT in the mechanisms of disease and T2D improvement observed after bariatric surgery.
Performance evaluation of a Wi-Fi-based multi-node network for distributed audio-visual sensors
Authors: Cecchinato Niccolò , Toma Andrea , Drioli Carlo , Ferrin Giovanni , Foresti Gian Luca 
Published: March 2023

AbstractThe experimental research described in this manuscript proposes a complete network system for distributed multimedia acquisition by mobile remote nodes, streaming to a central unit, and centralized real-time processing of the collected signals. Particular attention is placed on the hardware structure of the system and on the research of the best network performances for an efficient and secure streaming. Specifically, these acoustic and video sensors, microphone arrays and video cameras respectively, can be employed in any robotic vehicles and systems, both mobile and fixed. The main objective is to intercept unidentified sources, like any kind of vehicles or robotic vehicles, drones, or people whose identity is not a-priory known whose instantaneous location and trajectory are also unknown. The proposed multimedia network infrastructure is analysed and studied in terms of efficiency and robustness, and experiments are conducted on the field to validate it. The hardware and software components of the system were developed using suitable technologies and multimedia transmission protocols to meet the requirements and constraints of computation performance, energy efficiency, and data transmission security.
Fault-tolerant control for an electro-hydraulic servo system with sensor fault compensation and disturbance rejection
Authors: Phan Van Du , Ahn Kyoung Kwan 
Published: March 2023

AbstractThe electro-hydraulic servo system (EHSS) usually faces multiple sensor faults and disturbances, which is difficult to achieve good tracking control, reliability, and stability control. In this article, an advanced fault-tolerant controller is proposed for an EHSS to deal with the above challenge. The three fault observers, called nonlinear unknown input observers (NUIOs), are developed to effectively estimate the position, velocity, pressure sensor faults and the system states. The fault detection, estimation, and isolation are then presented as effective for multiple sensors failure at a time. The first NUIO for position sensor fault is utilized for the tracking control, while the other NUIOs are used for alarm proposal. The adverse effects caused by the matched and unmatched disturbances are eliminated by two extended state observers (ESOs). In addition, to avoid the “explosion of complexity” when computing the derivatives of virtual control laws, the dynamic surface control is applied to design the fault-tolerant control (FTC) scheme. The Lyapunov principle ensures system stability under lumped disturbance and faulty conditions. Finally, simulation studies and evaluation results are performed to demonstrate the validity of the proposed FTC algorithm.
The Fertility Response to Cutting Child-Related Welfare Benefits
Authors: Sandner Malte , Wiynck Frederik 
Published: March 2023

AbstractDespite long-term interest in whether welfare benefits motivate fertility, evidence from research has not been consistent. This paper contributes new evidence to this debate by investigating the fertility effect of a German welfare reform. The reform decreased the household income of families on welfare by 18% in the first year after the birth of a baby. Using exclusive access to German social security data on over 460,000 affected women, our analysis finds that the reform leads to a fertility reduction of 6.8%. This result implies that for mothers on welfare, fertility has an income elasticity of 0.38, which is much smaller than that of general populations reported in the literature. Our findings suggest that welfare recipients’ fertility reacts less strongly to financial incentives than the fertility of overall populations.
A review and meta-analysis of the environmental biology of bleak Alburnus alburnus in its native and introduced ranges, with reflections on its invasiveness
Authors: Latorre Dani , Masó Guillem , Cano-Barbacil Carlos , Zamora-Marin José M. , Almeida David , Vilizzi Lorenzo , Britton J. Robert , Cruz Alejandra , Fernández-Delgado Carlos , González-Rojas Anni G. , Miranda Rafael , Rubio-Gracia Francesc , Tarkan Ali Serhan , Torralva Mar , Vila-Gispert Anna , Copp Gordon H. , Ribeiro Filipe 
Published: March 2023

AbstractThe bleak Alburnus alburnus is a medium body-size leuciscid fish that is naturally distributed across central European and western Asian fresh waters. However, during the last two decades A. alburnus has been widely introduced elsewhere in Europe and in northern Africa, mostly as a forage species for game fishes. Given its relatively recent history of invasion in non-native Eurasian waters, where it can become highly abundant, A. alburnus poses a serious risk to native communities where introduced. This study provides a review and meta-analysis of the biological traits of A. alburnus coupled with insights into its invasiveness. In its native range, A. alburnus has a moderate lifespan, inhabiting lakes or still waters in medium-to-large rivers, where it feeds mainly on zooplankton. However, non-native A. alburnus populations display high phenotypic plasticity in their biological attributes. Thus, growth, reproductive and/or dietary traits have adapted to local environmental conditions, with the species also invading lotic (stream) ecosystems. Feeding changes to benthic invertebrates, plant material and detritus when zooplankton is scarce. Such plasticity, including broad physiological tolerance, is likely to facilitate the species' adaptation and invasion of new habitats in the near future.
The deep neural network approach to the reference class problem
Authors: Buchholz Oliver 
Published: March 2023

AbstractMethods of machine learning (ML) are gradually complementing and sometimes even replacing methods of classical statistics in science. This raises the question whether ML faces the same methodological problems as classical statistics. This paper sheds light on this question by investigating a long-standing challenge to classical statistics: the reference class problem (RCP). It arises whenever statistical evidence is applied to an individual object, since the individual belongs to several reference classes and evidence might vary across them. Thus, the problem consists in choosing a suitable reference class for the individual. I argue that deep neural networks (DNNs) are able to overcome specific instantiations of the RCP. Whereas the criteria of narrowness, reliability, and homogeneity, that have been proposed to determine a suitable reference class, pose an inextricable tradeoff to classical statistics, DNNs are able to satisfy them in some situations. On the one hand, they can exploit the high dimensionality in big-data settings. I argue that this corresponds to the criteria of narrowness and reliability. On the other hand, ML research indicates that DNNs are generally not susceptible to overfitting. I argue that this property is related to a particular form of homogeneity. Taking both aspects together reveals that there are specific settings in which DNNs can overcome the RCP.
Genome-wide analysis of BrbHLH gene family and functional identification of the involvement of BcbHLH57 in abiotic stress in wucai (Brassica campestris L.)
Authors: Zhang Bingsheng , Zhang Liting , Lan Tian , Zhu Shidong , Hou Jinfeng , Chen Guohu , Tang Xiaoyan , Gan Defang , Wang Chenggang , Yuan Lingyun 
Published: March 2023

AbstractWucai (Brassica campestris L. ssp. chinensis var. rosularis Tsen) is a subspecies of Brassica campestris, is a kind of cold-tolerant vegetable widely cultivated in the Yangtze-Huai River Basin of China. To breed new varieties of resistance to stress, it is necessary to study the tolerance of Resistance to different stresses. Transcriptomic data showed that exogenous application of 2, 4-epbrassinolide (EBR) significantly increased the bHLH genes expression in wucai at low temperature, and bHLH57 was up regulated significantly. BHLH (Basic helix-loop-helix) TFs (transcription factor) is a superfamily of TFs with complex functions and related to various plant life activities. In this study, a total of 239 bHLH genes were identified, and their amino acid physicochemical properties, chromosome location, gene structure, phylogeny and cis-acting elements were analyzed by bioinformatics. Phylogenetic analysis showed that bHLH gene families in Brassica rapa and Arabidopsis were divided into six groups, and the distribution of bHLH genes in Brassica rapa was uneven. The BrbHLHs were irregularly mapped in the cultivated B. rapa genome. The maximum number (40) of BrbHLH genes were mapped on Chr09. In addition, there were tandem repeats in some genes. The collinearity analysis showed that 152 AtbHLH genes and 239 BrbHLH protein genes formed 296 collinearity pairs, and the Ka/Ks ratio ofall duplicated BrbHLH gene pairs had a Ka/Ks ratio of < < 1, indicating that the bHLH family genes may have undergone strong purification and selection during the evolution process. Cis-acting elements analysis showed that the promoter region of bHLH family genes in Brassica rapa had more responsive elements related to light, hormone and abiotic stress. The BcbHLH57 overexpressing Arabidopsis thaliana lines were subjected to different stress treatments, and the seed germination rate, root growth, survival rate and various plant physiological indexes were determined. The results showed that the transgenic lines were more tolerant to salt, heat and drought stress. In this study, the response of BcbHLH57 gene to salt, heat and drought stress was reported for the first time, which provided a basis for further research on the function of BcbHLH57 in abiotic stress.
Dynamic Relative Permeabilities for Partially Saturated Porous Media Accounting for Viscous Coupling Effects: An Analytical Solution
Authors: Solazzi Santiago G. , Jougnot Damien , Rubino J. Germán , Holliger Klaus 
Published: March 2023

AbstractWe present an analytical model to compute frequency-dependent relative permeability functions for partially saturated porous media accounting for viscous coupling effects. For this, we consider the oscillatory motion of two immiscible fluid phases and solve the Navier–Stokes equations at the pore scale using suitable interface conditions between fluids. These calculations are combined with the generalized two-phase flow Darcy equations to obtain the corresponding upscaled macroscopic fluxes. By means of an analog pore model consisting of a bundle of cylindrical capillaries in which pore fluids are distributed in a concentric manner, we find closed analytical expressions for the complex-valued and frequency- and saturation-dependent relative permeability functions. These expressions allow for a direct assessment of viscous coupling effects on oscillatory flow for all frequencies and saturations. Our results show that viscous coupling effects significantly affect flow characteristics in the viscous and inertial regimes. Dynamic relative permeabilities are affected by the pore fluid densities and viscosities. Moreover, viscous coupling effects may induce two critical frequencies in the dynamic relative permeability curves, a characteristic that cannot be addressed by extending the classic dynamic permeability definition to partially saturated scenarios using effective fluids. The theoretical derivations and results presented in this work have implications for the estimation and interpretation of seismic and seismoelectric responses of partially saturated porous media.
Solving the Authority Problem: Why We Won’t Debate You, Bro
Authors: Cousens Chris 
Published: March 2023

AbstractPublic arguments can be good or bad not only as a matter of logic, but also in the sense that speakers can do good or bad things with arguments. For example, hate speakers use public arguments to contribute to the subordination of their targets. But how can ordinary speakers acquire the authority to perform subordinating speech acts? This is the ‘Authority Problem’. This paper defends a solution inspired by McGowan’s (Australas J Philos 87:389–407, 2009) analysis of oppressive speech, including against concerns raised by McGowan (Just words: On speech and hidden harm, Oxford University Press, Oxford, 2019) herself. A deflated kind of authority can be gained from the hate speaker’s standing in a norm-governed ‘activity of oppression’. We should be wary about engaging with such speakers in public argument. Even if we counter their arguments, we may still elevate their standing within that activity and so enable them to perform more pernicious speech acts than was previously possible.
What is the sensitivity and exactness of post-mortem diagnostic method for cardiopulmonary nematodes in wild carnivores? towards the gold standard
Authors: Arcenillas-Hernández Irene , de Ybáñez M. R. Ruiz , Martínez-Carrasco Carlos 
Published: March 2023

AbstractCardiopulmonary nematodes cause health and fitness disorders in wild and domestic carnivores. The red fox (Vulpes vulpes) participates in the spread of these shared parasites at the domestic-wildlife interface. This study aimed to evaluate the sensitivity of post-mortem diagnostic method for detecting lungworms in carnivores, and its exactness to estimate the parasite intensity of each nematode species. Cardiorespiratory system of fifty-one foxes were examined through three consecutively methodological steps: first, the tracheobronchial tree, pulmonary arteries and their branches were opened (OT); next, lung parenchyma was immersed in water and squeezed (WS); finally, the parenchyma was artificially digested in a pepsin and chlorhydric acid solution (AD).Eucoleus aerophilus,Angiostrongylus vasorum,Crenosoma vulpisandMetathelazia capsulatawere identified. The number of recovered nematodes in each step were 454 (OT), 285 (WS) and 141 (AD). The use of OT and WS helped to improve parasite intensity results and decreased false negative cases. Accordingly, when OT and WS were used together, the sensitivity in the detection of parasitized foxes was 96.1%, while the exactness of parasite intensity was 84%. When AD was performed, although sensitivity does not rise, results were more exact, increasing the total number of detected parasites by 16%. Moreover, AD improved the sensitivity in the detection ofA. vasorumandM. capsulata, as well as quantifying more exactly the parasite intensity (92.5% and 92.3% of exactness without AD, respectively). Our study provides valuable information that should be taken into account when planning epidemiological studies based on cardiopulmonary nematode detection in carnivores.
Multi-objective Optimisation Framework for Assessment of Trade-Offs between Benefits and Co-benefits of Nature-based Solutions
Authors: Yang Shengnan , Ruangpan Laddaporn , Torres Arlex Sanchez , Vojinovic Zoran 
Published: March 2023

AbstractUrbanization and climate change are producing an escalation in the prevalence of urban problems, particularly those connected to flooding, prompting authorities and stakeholders to recognize the need for sustainable solutions. Nature-Based Solutions are progressively replacing traditional engineering solutions as an alternative since they are more eco-friendly. By re-activating the urban hydrological cycle processes, NBS intends to increase the natural water storage capacity to help decrease urban flooding. The work described here outlines a framework for optimising the efficacy of NBS for flood risk reduction and its co-benefits, as well as defining the trade-offs among these co-benefits. The framework integrates 1D hydrodynamic models with multi-objective optimisation techniques. To demonstrate the applicability of the framework and its methods it has been used in Sint Maarten, which is an island located in the Caribbean Sea. Four NBS measure were identified as having good potential to be applied in the case study, namely: green roof, permeable pavement, bio-retention pond, and open detention basin. The results showed that the developed framework has the ability to represent the link between benefits and costs when evaluating various NBS, hence aiding the decision-making process to select and implement NBS.