bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of N2O emission factors derived from nitrification of treated sewage water in rivers
Authors: Yamazaki Hiroshi , Kagamu Ayaka , Kezuka Kenta , Murano Akito , Ebie Yoshitaka 
Published: May 2023

Abstract

Because treated sewage water contains nitrogen compounds such as NH4-N and NO2+3-N, nitrous oxide (N2O) which is one of the greenhouse gases is generated by nitrification and denitrification reactions in rivers. This study aimed to develop a method for estimating the amount of N2O generated from the nitrification of residual N compounds in treated sewage water by subtracting the amount of residual N2O dissolved in the treated sewage water. A year-round field survey of dissolved N2O (D-N2O) in the treated sewage water and river water showed that nitrification proceeded in the downstream direction in the rivers following the discharge of the treated sewage water, thereby generating N2O. The deaeration rate of N2O dissolved in the river water was obtained from a laboratory experiment. The N2O emission factor that can be applied to in-river nitrification of NH4-N contained in the treated sewage water was calculated to be 0.0025 kgN2O-N kgNH4-N-1.
Application of Platelet-Rich Plasma as a Stem Cell Treatment - an
Attempt to Clarify a Common Public Misconception
Authors: Fareez Ismail M. , Liew Fong Fong , Widera Darius , Mayeen Naiyareen Fareeza , Mawya Jannatul , Abu Kasim Noor Hayaty , Haque Nazmul 
Published: May 2023

Abstract:
In recent years, there has been a significant increase in the practice of regenerative
medicine by health practitioners and direct-to-consumer businesses globally.
Among different tools of regenerative medicine, platelet-rich plasma (PRP) and
stem cell-based therapies have received considerable attention. The use of PRP, in
particular, has gained popularity due to its easy access, simple processing techniques,
and regenerative potential. However, it is important to address a common misconception
amongst the general public equating to PRP and stem cells due to the demonstrated
efficacy of PRP in treating musculoskeletal and dermatological disorders. Notably,
PRP promotes regeneration by providing growth factors or other paracrine factors only.
Therefore, it cannot replenish or replace the lost cells in conditions where a large
number of cells are required to regenerate tissues and/or organs. In such cases, cellbased
therapies are the preferred option. Additionally, other tools of regenerative medicine,
such as bioprinting, organoids, and mechanobiology also rely on stem cells for
their success. Hence, healthcare and commercial entities offering direct-to-customer
regenerative therapies should not mislead the public by claiming that the application of
PRP is a stem cell-based therapy. Furthermore, it is important for regulatory bodies to
strictly monitor these profit-driven entities to prevent them from providing unregulated
regenerative treatments and services that claim a broad variety of benefits with little
proof of efficacy, safety concerns, and obscure scientific justification.
Salivary Protein Biomarkers for Diagnosis of Oral Squamous Cell
Carcinoma
Authors: Navale Archana M. , Deshpande Atharva , Mistry Bini , Chauhan Premal , Bhagat Charansharan 
Published: May 2023

Abstract:
OSCC (Oral Squamous Cell Carcinoma) is a major health challenge in many parts of the
world. It occurs most commonly in males and is associated with tobacco, pan, or areca nut consumption.
One of the major challenges associated with the management of OSCC is late diagnosis. As a
result, the treatment required is more aggressive, expensive, and has poor prognostic value. On the
other hand, early diagnosis of OSCC can be life-saving with less aggressive treatment and a better
prognosis.

:
A diagnostic method for early diagnosis of OSCC is greatly needed. A lot of research efforts have
been made to identify biomarkers that can act as tools to classify the tumor status of the patient. Various
biological fluids and tissues have been explored for such studies. Saliva appears to be the most
attractive biological sample with many potential advantages over other matrices such as blood or tissue.
Saliva as a diagnostic fluid has the advantage of ample availability, being non-invasive and being
in the vicinity of the tumor, and having a less complex composition. Our paper provides an updated
review of the state of the art of research in the area of salivary biomarkers for oral squamous cell carcinoma.
The paper gives an account of methods for saliva collection, followed by a brief description of
various protein biomarkers discovered to date, along with their status quo.
Tumor-selective Blockade of CD47 Signaling with CD47 Antibody for
Enhanced Anti-tumor Activity in Malignant Meningioma
Authors: Liu Xiaotong , Zhang Huarong , Wang Chaohu , Li Zhiyong , Zhu Qianchao , Feng Yiwen , Fan Jun , Qi Songtao , Wu Zhiyong , Liu Yi 
Published: May 2023

Background:
Patients with WHO grade III meningioma have a poor prognosis with a median
survival of less than two years and a high risk of recurrence. However, traditional treatment options
have failed to improve prognosis. Therefore, development of novel immunotherapy targets is urgently
needed. CD47 acting as a “don't eat me” signal to macrophages can trigger tumor immune escape.
However, the role of CD47 in malignant meningioma is not well understood.

Methods:
We collected 190 clinical meningioma samples and detected the expression of CD47 and
immune infiltration in WHO grade I-III by immunohistochemistry, western blot, qPCR. We also examined
the functional effects of anti-CD47 on cell proliferation, migration and invasion, macrophagemediated
phagocytosis and tumorigenicity both in vitro and in vivo.

Results:
We found that the expression of CD47 was increased in malignant meningioma along with a
decreased number of T cells and an increase in CD68+ macrophages. Blocking CD47 with anti-CD47
antibody (B6H12) suppressed tumor cell growth, motility and promoted macrophage-mediated phagocytosis
in IOMM-Lee cells in vitro. In vivo experiments showed that anti-CD47 antibody (B6H12 or
MIAP301) significantly inhibited the tumor growth and this effect was partly blocked by the depletion
of macrophages. Finally, p-ERK and EGFR showed higher expression in malignant meningioma with
high expression of CD47, which was verified by western blot.

Conclusion:
Our results demonstrated that CD47 maybe involved in the meningioma progression and
prognosis and offered a novel therapeutic option by targeting CD47 in malignant meningioma.
A Decennial Update on the Applications of Trifluroacetic Acid
Authors: Alam Mohammed Mujahid , Varala Ravi , Seema Vittal 
Published: May 2023

Abstract:
Since its discovery at the beginning of the 20th century, trifluoroacetic acid, commonly
known as TFA, has seen extensive application in organic synthesis both as a solvent and as a catalyst/
reagent. TFA can be used to facilitate a wide variety of chemical transformations, including rearrangements,
functional group deprotections, condensations, hydroarylations and trifluoroalkylations,
among others. The decennial mini-review examines key TFA synthetic applications from the middle
of 2013 to the present, providing the organic chemistry research community with an opportunity to
delve deeply into the numerous and varied applications of this strong acid, water-miscible, and low
boiling point reagent.
Phytogenic One-pot Synthesis and Spectroscopic Characterization of Novel
Mono Benzylated Resveratrol Hybrid Molecule Using Extracted Resveratrol
from Green Grape Peels: In Silico ADMET Study and In Vitro Antitumor
Activities Against Breast Cancer Cells
Authors: Roy Lairikyengbam Deepti , Kumar Jyotsna , Krishnamurthy Geeta , Gour Pooja , Arland Shivanjali Esther , Rahman Naveed 
Published: May 2023

Background:
Despite the development of numerous customized techniques for treating breast cancer, cancer patients' clinical results revealed adverse consequences in addition to chemotherapeutic drug resistance. Hence, finding therapeutic compounds with little or no side effects becomes essential in the fight against cancer. Resveratrol, a naturally occurring non-flavonoid polyphenol present in plants as a phytoalexin, is a promising therapeutic agent that has garnered the interest of several researchers due to its prodigious pharmacological and biological activities, but its unfavourable pharmacokinetic properties complicated its clinical studies. Along with several structural modifications, substitutions, etc., that have already been reported, this is the first time that a novel resveratrol analogue comprising an aromatic hetero moiety (ResD1) was synthesized using resveratrol isolated from grape (Vitis vinifera) peels as a precursor.

Methods:
ResD1 was synthesized by one-pot reaction using extracted and isolated resveratrol from grape peels. Structure confirmation of the isolated resveratrol and synthesized resveratrol derivative was elucidated by 1H-NMR, 13C-NMR, FTIR, and LC-MS. In silico molecular docking and ADMET study of ResD1 were carried out using AutoDock 4.2 and ADMETLab 2.0. ResD1 was evaluated for in vitro antioxidant, antimicrobial, anticancer, and CAXII gene expression as per the standard methods.

Results:
In silico molecular docking results revealed that ResD1 is capable of attaching to the ERα (estrogen receptor alpha) protein via hydrogen and hydrophobic bonds and has -7.12 kcal/mol as docking score. The novel derivative (IC50 = 42.8 µg/ml) exhibited better radical scavenging ability than ascorbic acid (control). The antimicrobial activities exemplify that it can induce microbial cell death for all the strains at higher concentrations. MTT assay results portrayed the potent antiproliferative activity against MCF-7 cell lines (IC50 = 155.2 µg/ml) and non-cytotoxicity for MDA-MB-231 cell lines. Moreover, the synthesized resveratrol derivative induced ROS (reactive oxygen species) levels in MCF-7 cells, indicating cytotoxicity. CAXII gene expression study showed that it downregulated the CAXII genes.

Conclusion:
This study serves as an example of how a newly proposed resveratrol analogue might be utilized as a viable pharmacophore for specifically targeting the ER alpha protein which will be beneficial in investigating a fresh batch of effective resveratrol mimics as prospective anticancer agents.
Calculation of the load-bearing capacity of the bent plates taking into account the diagrams of concrete deformation
Authors: Dzhankulaev A. Y. , Shogenov O. M. , Likhov Z. R. , Kaziyev A. M. , Blyanikhov I. A. 
Published: May 2023

Objective. The influence of the nature of the descending branch of concrete compression and stretching diagrams on the ultimate load-bearing capacity of bent cross-section reinforced concrete structures under various loading conditions close to destruction according to the nonlinear finite element model is investigated.Method. The solution is performed by the finite element method in a physically nonlinear formulation using N.I.Karpenko's deformation theory. Deformation diagrams are used with different steepness of the descending branch. Calculations are performed by a step-by-step iterative method of successive loads on a layered model.Result. The results of numerical calculation of slab reinforced concrete elements under various conditions of physical nonlinearity of concrete are presented.Conclusion. The insignificant influence of the steepness of the descending branch on the load-bearing capacity of plate bendable structures has been found and the use of simplified diagram dependencies is fully justified for numerical calculations using a nonlinear model.
Filled bituminous compositions in the construction industry
Authors: Kindeev O. N. , Vysotskaya M. A. , Kurlykina A. V. 
Published: May 2023

Objective. The properties of road bitumen, when interacting with the components of building compositions, are always transformed relative to their original properties. Therefore, when working with materials based on filled bitumen compositions, regardless of their field of application, the main task is to monitor the dynamics of changes in characteristics and control in the required direction, as well as maintaining properties such as viscosity, flexibility and fluidity. The purpose of the work is to study the effect of modifying additives of various bases (fillers, plasticizers and waxes) on the properties of a bituminous binder and to evaluate the effectiveness of their contribution to the formation of filled bitumen compositions for the construction industry.Method. The methodological basis of the work is the principle of bitumen structure formation. Experimental studies were carried out using standard and special methods.Result. The results obtained showed that fiberglass fiber proved to be the best filler in the bitumen composition. In the study of plasticizers, it was revealed that the most pronounced positive plasticizing effect is observed from the use of an extract of selective oil purification, which allows you to control the flexibility of the system in a wide range. It has been established that the plasticizer polyalkylbenzene effectively regulates the properties of the composition at negative temperatures, slightly affecting the heat resistance. The results of the wax study show that Titan synthetic wax and Viscobit polyethylene wax are evenly distributed in the volume of the bituminous binder and provide stabilization of the system properties.Conclusion. In the process of performing the study, as well as analyzing the results obtained, 3 groups of bituminous matrix filler additives were studied. It has been established that the directed regulation of the properties of bitumen systems is possible due to the rational choice of the type of additive-filler. Thus, using complex fillings of the bitumen matrix when designing bitumen compositions with the possibility of regulating and normalizing their properties (optimization indicators), it is possible to obtain economic and operational effects.
Modeling of regasification and recirculation processes during the transportation of liquefied natural gas
Authors: Baranov A. Yu. , Seredenko E. S. , Malysheva T. A. , Kravchenko Yu. A. 
Published: May 2023

Objective. The purpose of the research is modeling and analysis of technological processes occurring at the transshipment terminal of liquefied natural gas.Method. The study is based on the methods of thermodynamic analysis, full-scale and computational modeling of processes and objects of refrigeration and cryogenic equipment in order to find optimal solutions in terms of efficiency, reliability and service life of low-temperature installations, machines and apparatus.Result. The article describes the operation algorithm of an LNG transshipment terminal and proposes a mathematical apparatus for modeling the technological processes occurring in it. Information about the causes of the formation of LNG vapors (Boil-off gas (BOG)) during its transportation and reloading is presented, methods for utilizing excess LNG vapors are considered.Conclusion. To maintain the cryogenic temperature of the unloading arms, an LNG recirculation line (recirculation pipelines) is provided.
Gender and Spatial Variations in the Use of Digital Media Related to Adolescents Reproductive Health in Yogyakarta Post-Pandemic Covid-19
Authors: Mulyani Wiwik Puji , Safira Mitha 
Published: May 2023

Teenagers have an essential role as part of the development. The proportion of youth ranks highest in the overall population in the world, including Indonesia. The development of the digital world occurs along with the transition of adolescent life which has both good and bad impacts. The impact of the Covid-19 Pandemic became an accelerator for increasing the utility of youth towards digital media. The increase in risky behavior due to technological developments carried out by adolescents raises concerns. On the other hand, technological developments can also positively impact increasing knowledge and attitudes/behaviors, especially regarding health and reproductive issues which are closely related to adolescent development. The purpose of this study was to analyze the knowledge and attitudes/ behaviors of adolescents related to reproductive health, adolescent characteristics and differences in adolescent knowledge according to their demographic characteristics and to analyze the use of digital media for Communication, Information, and Education (IEC) for post-pandemic adolescent reproductive health. This research is quantitative research and the unit of analysis used is the individual level (adolescents). The number of samples was 130 youth and data were analyzed by descriptive quantitative. The results of the study show that adolescents’ knowledge of reproductive health is in a good category, but still needs to be improved. Likewise, regarding attitudes and behavior, there are a few teenagers who have attitudes and behaviors which are vulnerable to problems, such as the consumption of alcohol, cigarettes, drugs, free sexual relations, and others. There are four major digital platforms which are often used and teenagers are comfortable using them to access reproductive health knowledge and information, specifically online mass media, Instagram (IG), Tiktok, and Youtube.
Analisis Kolaborasi Institusi pada Publikasi Ilmiah Indonesia Berbasis Data Jurnal Ilmiah Indonesia
Authors: Tupan Tupan , Ningsih Maha Rahmadani , Sihombing Andre , Nababan Ruth T.P. 
Published: May 2023

Kolaborasi penelitian maupun publikasi ilmiah yang dilakukan individu maupun institusi bertujuan meningkatkan kualitas penelitian maupun publikasi ilmiah. Kolaborasi menciptakan hubungan individu dengan institusi yang saling membantu dalam peningkatan kualitas penelitian. Berdasarkan permasalahan tersebut dilakukan analisis kolaborasi institusi pada publikasi jurnal ilmiah Indonesia berbasis data Indonesian Scientific Jurnal Database (ISJD). Penelitan bertujuan mengetahui 1) publikasi berdasarkan kategori; 2) publikasi institusi per tahun; 3) sepuluh institusi terproduktif dalam publikasi; 4) kolaborasi institusi terbanyak; dan 5) perbandingan kategori kolaborasi berdasarkan institusi. Analisis menggunakan metode deskriptif. Penelitian dilakukan selama Oktober sampai November 2021 dengan menggunakan Dashboard ISJD (lipi.go.id) Data diperoleh melalui proses penelusuran terhadap jurnal ilmiah Indonesai kurun 2017– 2019. Hasil analisis menunjukkan: 1) publikasi berdasarkan kategori terbanyak adalah bidang pendidikan (29.702 publikasi), kesehatan dan kedoteran (15.274 publikasi), ekonomi (13.676 publikasi), rekayasa (13.156 publikasi), dan manajemen (12.502 publikasi); 2) dari 10 institusi menunjukkan bahwa tahun 2017 merupakan tahun dengan jumlah publikasi terbanyak. Institut Pertanian Bogor (IPB) paling banyak mempublikasikan dalam kategori pertanian. Lembaga Ilmu Pengetahuan Indonesia (LIPI) paling banyak mempublikasikan dalam kategori biologi; 3) terdapat sepuluh institusi terproduktif dalam publikasi; 4) kolaborasi institus terbanyak, dimana Institut Pertanian Bogor merupakan institusi terbanyak berkolaborasi; dan 5) data perbandingan kategori kolaborasi berdasarkan institusi.
RESPONSIBILITAS PEMERINTAH KABUPATEN ACEH SELATAN TERHADAP MEKANISME HARGA
Authors: M. Yunus Fakhrurrazi , Mustika Rani Silvi 
Published: May 2023

ABSTRAK
Penetapan harga merupakan salah satu upaya yang dilakukan pemerintah Aceh Selatan untuk meningkatkan kesejahteraan perekonian masyarakat, Ketika perekonomian masyarakat merosot yang diakibatkan harga pala menurun, maka pihak pemerintah memiliki wewenang untuk mengeluarkan kebijakan. Metode penetapan harga ini tidak dilarang di dalam Islam dengan ketentuan harga yang ditetapkan oleh pihak pemerintah tidak menzalimi antara penjual dan pembeli. Hal ini menjadi permasalahan dan tujuan dalam penelitian yaitu bagaimana fluktuasi harga pala dan pengaruhnya terhadap petani pala di kabupaten Aceh Selatan, tingkat intervensi pemerintah kabupaten Aceh Selatan dalam memproteksi harga pala yang di tinjau menurut hukum Islam serta tingkat keberhasilan pemerintah kabupaten Aceh Selatan dalam menetralisir harga pala. Untuk mencapai tujuan penelitian, peneliti menggunakan metode deskriptif analisis, sedangkan teknik pengumpulan data primer diperoleh melalui penelitian lapangan sedangkan data sekunder melalui penelitian perpustakaan. Dari hasil penelitian dapat diketahui harga pala memiliki peran yang sangat penting bagi pentani Aceh Selatan. Fluktuasi harga pala terjadi pada tahun 2014 sampai tahun 2018, pada saat harga pala tinggi perekonomian masyarakat bisa terpenuhi bukan hanya kebutuhan pokok, bahkan kebutuhan sekunder begitu juga sebaliknya menurunnya harga pala, masyarakat kehilangan sumber pendapatan dan mengalami kemiskinan. Pemerintah tidak bisa intervensi harga dalam pasar karena tergantung kepada permintaan dan penawaran serta kerelaan antara penjual dan pembeli. Tingkat keberhasilan yang dilakukan pemerintah kabupaten Aceh Selatan sedikit banyaknya sudah berhasil, seperti membasmi penyakit pala sehingga produksi menjadi lebih baik, bersosialisasi dengan masyarakat dan membentuk Lembaga Ekonomi Masyarakat
Professional development of Indonesian in-service EFL teachers: Perceived impacts and challenges
Authors: Averina Fidelis Elleny , Kuswandono Paulus 
Published: May 2023

Despite the growing interest in research on Teacher Professional Development (TPD) carried out by previous researchers, the voices of local EFL teachers in different regions in Indonesia in which top-down TPD activities are still prevalent remain underrepresented. As a result, in order to fill a gap in the literature, the current study sought to investigate the TPD activities undertaken by EFL teachers, the extent to which those formal TPD programs had an impact on their professional development based on their perceptions, and the constraints that they encountered. This descriptive qualitative study utilized a questionnaire and semi-structured interview as the instruments to gather the data and ensure triangulation for trustworthiness. Twenty-five English teachers from various Junior High schools associated with MGMP in Cirebon, West Java were voluntarily involved in this research. The result revealed that TPD activities that the participants have undertaken all these times helped them improve self-efficacy, attitudes, beliefs, reflective competence, classroom practice and instructional skills, and teacher knowledge and skills. Nevertheless, some challenges such as excessive workload as a teacher, time constraints or mismatched schedule, limited choices of TPD programs that were not in line with teachers’ interests, the mismatch between teachers’ needs and what the program offered, limited access and information about the programs, and less effective program duration remained prevalent during the TPD program implementation.
FEE SYSTEM ANALYSIS AND ITS DISPARITY UNDER BSI SMART AGENT SERVICES IN THE SAMSARAH PERSPECTIVE
Authors: Khalidin Bismi , Zahara Alfi 
Published: May 2023

The agreement of the two parties in entering into an agreement is part of the legal requirements for the validity of the agreement. The purpose of this study is to determine the fee rate determined by BSI management, the fee disparity set by BSI Smart Agent management with similar services, and the perspective of the samsarah contract on fee levels and their disparities with similar services. This research explores a descriptive method and the data was collected through interviews and documentation. The study found that, based on data analysis in the agreement, BSI management has arranged systematically and clearly regarding the level of fees in which the agent will receive. In the agreement, it is stated that the agent must comply with all the conditions set. The fee disparity occurs because BSI management has set rules for fee rates but the agent does not understand the rules that have been approved and ratified by both parties, in which this action causes the contract requirements not to be fulfilled. This study concludes that in reality there is a problem in the implementation of the samsarah contract carried out by the agent, namely applying a different fee system from the contents of the agreement without the consent of both parties