bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Anterior Segment Morphology and Intraocular Pressure after Cataract Surgery in Non-glaucomatous Eyes
Authors: Giglio Rosa , Inferrera Leandro , De Giacinto Chiara , DʼAloisio Rossella , Beccastrini Andrea , Vinciguerra Alex Lucia , Perrotta Alberto Armando , Toro Mario Damiano , Zweifel Sandrine , Tognetto Daniele 
Published: April 2023

Abstract
Background It is known that cataract extraction is associated with a significant reduction in intraocular pressure, especially in narrow angled eyes; however, the modifications of
anterior segment parameters associated with this phenomenon have still not been completely defined. The purpose of this study was to evaluate changes in anterior segment anatomy and
intraocular pressure after cataract surgery in non-glaucomatous eyes.
Methods and Material This retrospective case series study included 64 eyes of 64 consecutive patients who underwent phacoemulsification with intraocular lens implantation. Anterior
segment parameters and intraocular pressure were assessed and compared before and 6 months after surgery. Anterior segment imaging was performed using Casia SS-1000 anterior segment optical
coherence tomography (Tomey, Nagoya, Japan). Anterior segment measurements included anterior chamber depth, anterior chamber width, anterior chamber volume, angle opening distance at 500 µm
anterior to the scleral spur, angle recess area 750 µm from the scleral spur, lens vault, trabecular iris space area at 500 µm from the scleral spur, and trabecular iris angle at 500 µm from
the scleral spur. Intraocular pressure was measured using the Goldmann applanation tonometer (Model AT 900 C/M, Haag-Streit, Bern, Switzerland). Anterior segment parameters and the
relationship of changes in intraocular pressure were also evaluated.
Results All anterior segment parameters increased significantly after surgery (p < 0.05). Both angle opening distance at 500 µm anterior to the scleral spur and anterior chamber
depth changes were positively correlated with the preoperative lens vault. The mean intraocular pressure significantly decreased from 14.91 mmHg (± 2.8 SD) to 12.91 mmHg (± 3.13 SD)
(p < 0.001). Changes in intraocular pressure correlated negatively with values for the width of the preoperative anterior chamber (r = − 0.533; p = 0.001).
Conclusion Cataract surgery led to significant widening of the anterior chamber angle and lowering of intraocular pressure. Further investigations are needed to better understand
whether anterior chamber width may be a new independent predictive factor for reduction in postoperative intraocular pressure.
Retrospective Comparison of the Myopia Master and the Lenstar LS900 Axial Length Measurements in Children with Myopia
Authors: Sivakumar Thibika , Palmowski-Wolfe Anja 
Published: April 2023

Abstract
Background This study is a retrospective analysis to compare ocular biometry measurements of axial length in children with myopia using Myopia Master (OCULUS, Wetzlar, Germany) and
Lenstar LS900 (HAAG-STREIT AG, Köniz, Switzerland).
Patients and Methods Axial length measurements obtained with both instruments within a 3-week period were collected retrospectively. Measurements were visualized with a Bland-Altman
plot. For statistical evaluation, a paired t-test was applied, and the Pearson correlation coefficient (r) was established.
Results Sixty-one eyes from 31 myopic patients (59% male, 41% female) with a mean age of 11.34 ± 3.25 years (range: 6 – 18 years) were identified. Mean axial length was 24.7 mm (SD
1.29) with the Myopia Master and 24.69 mm (SD 1.30) with the Lenstar LS900 (Pearson correlation: r = 0.9991). The average difference of the axial length measurement between the two biometers
was 0.00 064 mm ± 0.056 SD (p = 0.9293).
Conclusion The axial length measured by Myopia Master and Lenstar LS900 did not differ significantly. Thus, previous values obtained with the Lenstar LS900 can be applied to assess
myopia progression.
Natural Course of Solar and Laser-Associated Retinal and Macular Injuries at a Primary Care Hospital in Switzerland
Authors: Wiest Maximilian Robert Justus , Gunzinger Jeanne Martine , Hamann Timothy , Fasler Katrin , Said Sadiq , Bajka Anahita , Muth Daniel Rudolf , Barthelmes Daniel , Blaser Frank , Zweifel Sandrine Anne 
Published: April 2023

Abstract
Background Solar and laser-associated retinopathies are rare occurrences. The two retinopathies are both photo-induced but differ in the involved intensity and duration of exposure.
The purpose of this study was to evaluate the clinical features and natural course of these two entities, with a focus on the changes in the outer retina over time.
Patients and Methods This retrospective analysis assessed patients with solar or laser maculopathy seen at the Department of Ophthalmology of the University Hospital Zurich in
Switzerland over the last 10 years. Visual acuity (VA; Snellen) and optical coherence tomography (OCT) findings were reviewed and analyzed at baseline and last follow-up visit. Areas of
damaged outer retina, identified on en face OCT images as hyporeflective areas, were tagged and compared between visits. Descriptive analysis was performed by calculating mean values ±
standard deviation (SD). Statistical evaluation was done using the Wilcoxon signed rank test. A p value < 0.05 was considered statistically significant.
Results Five patients with solar retinopathy and six patients with laser-associated retinopathy were identified. In the solar retinopathy group, mean VA at baseline was 0.80
(SD ± 0.37) and improved to 0.90 (SD ± 0.36). This was not statistically significant (p = 0.066). In the laser-associated retinopathy group, mean VA at baseline was 0.89 (SD ± 0.18) and
improved to 1.03 (SD ± 0.09), which was not statistically significant either (p = 0.063). At baseline, in OCT cross-sections, initial changes were observed in the interdigitation, myoid, and
ellipsoid zone, as well as the outer nuclear layer and the Henle fiber layer. At follow-up, most cases presented an alteration in the residual ellipsoid zone, with the degree of the
aforementioned alterations depending on the size of the initial defect. A decrease of the hyporeflective alterations measured in en face OCT scans was observed in both groups but was only
statistically significant in the laser-associated retinopathy group (p = 0.018 versus p = 0.172).
Conclusions OCT can help to detect and monitor solar and laser-associated retinal injuries. Most injuries are minor, with good functional restitution. Minor changes in the ellipsoid
zone often persist, even in cases with full visual recovery.
Analysis of Blood Flow in the Macula and Optic Nerve Head in Healthy Young Volunteers Using Laser Speckle Flowgraphy
Authors: Bajka Anahita , Foa Nastasia , Sidhu Sophia , Rejdak Magdalena , Said Sadiq , Wiest Maximilian Robert Justus , Hamann Timothy , Muth Daniel , Blaser Frank , Zweifel Sandrine Anne 
Published: April 2023

Abstract
Purpose To assess optic nerve head (ONH) and macular blood flow in young healthy volunteers using laser speckle flowgraphy (LSFG).
Methods This is a prospective single-center study conducted at the Department of Ophthalmology, University Hospital Zurich from May to November 2021. Young, healthy men aged ≥ 18
years without ocular or systemic diseases were included. A corrected visual acuity (VA) of 0.0 logMAR or better in both eyes and an intraocular pressure (IOP) of 21 mmHg or lower were
required for inclusion. Subjects exceeding a spherical equivalent (SE) of ± 6 diopters (dpt) were excluded. Blood flow in the macula and the ONH was recorded using the Nidek LSFG RetFlow
device (Nidek Company, Ltd., Hirioshi-cho, Japan). Laser power was set to 0.5 Millivolts (mV). Mean blur rate (MBR) was recorded as a parameter for blood flow. MBR is a calculated parameter
that represents relative blood flow velocity correlated with the real anatomical blood flow rate. Colored heat maps of the recorded retinal area were generated automatically by the RetFlow
device.
Results Final analyses included 83 eyes of 43 male volunteers. Mean age was 21.9 years (SD ± 1.5, range: 20 to 29). Mean corrected VA was − 0.1 logMAR (SD ± 0.05, range: − 0.2 to
0.0), mean IOP was 15.4 mmHg (SD ± 2.5, range: 8.5 to 18.5), and mean SE was − 0.3 dpt (SD ± 1.2, range: − 5.0 to 1.2). Mean ONH MBR was 37.44 (SD ± 7.9, range: 22.5 to 53.5) and mean
macular MBR was 27.8 (SD ± 9.7, range: 6.4 to 57.7). Pearsonʼs Test showed a strong correlation between macular and papillary blood flow (p < 0.05, coefficient: 0.647).
Conclusion This study provides both ONH and macular blood flow data in a healthy young male population, showing a strong correlation between ONH and macular blood flow in the
examined eyes. Further investigations are required to assess the validity of MBR as a parameter for the combined evaluation of retinal blood flow at the macula and ONH in healthy volunteers
and patients with various diseases.
Preventive Inflammation Management with Steroids before Retreatment with Anti-VEGF after Severe Inflammation due to Brolucizumab
Authors: Karmy Badiaa El , Castro Daniela Gallo , Ambresin Aude 
Published: April 2023

Abstract
Purpose We report two successful cases of treatment by steroids after severe inflammation due to an intravitreal injection (IVI) of brolucizumab and their retreatment with another
type of anti-vascular endothelial growth factor (VEGF), with steroid treatments to prevent severe inflammatory recurrence in patients with exudative age-related macular degeneration
(AMD).
Clinical Cases, Case 1 An 88-year-old woman with exudative AMD in her left eye who had persistent subretinal fluid despite receiving an IVI, including ranibizumab and, subsequently,
aflibercept. A switch to brolucizumab was decided. Two weeks after the third dose, she had a visual loss decreasing from 20/40 to counting fingers at 50 cm. Fundus examination revealed
retinal whitening and perivenous sheathing. Fluoresceine angiography confirmed retinal arterial occlusion. Differential diagnoses were ruled out. She was treated with intravenous
methylprednisolone and prednisolone eye drops. Three months after the treatment, visual acuity improved to 20/80 with no intraocular inflammation but subretinal fluid recurred. IVI of
ranibizumab was rescheduled with preventive treatment by oral and local prednisolone without any inflammation recurrence.
Case 2 An 80-year-old man with exudative AMD in his right eye who had persistent subretinal fluid despite an IVI of aflibercept. Switching him to brolucizumab was decided. Two months
after the third dose, he had blurred vision with no pain. Visual acuity decreased from 20/20 to 20/25. Examination showed 1+ anterior chamber cells and hyalitis. We confirmed the diagnosis
of anterior uveitis with hyalitis. Differential diagnoses were ruled out. Treatment by prednisolone eye drops was initiated every 30 minutes for 1 day with a gradual decrease for 6 weeks.
One week later, visual acuity improved to 20/20 with no inflammation. Three weeks later, subretinal fluid due to AMD increased. The patient was retreated by aflibercept with prednisolone eye
drops, 48 hours before and after the IVI, with no recurrence of inflammation.
Discussion Brolucizumab is one of the latest FDA-approved anti-VEGF agents for wet AMD. Since its wider use, few cases of severe ocular inflammation have been reported in
post-marketing analysis. Because wet AMD recurrences should be expected after intraocular inflammation, insight is needed into treatment tolerance in cases that received further IVI
retreatment.
Conclusion Our cases demonstrate that an IVI reinjection with a different anti-VEGF drug for exudative AMD recurrence can be safely reperformed. The use of local steroids could be
effective in preventing recurrence of ocular inflammation after severe intraocular inflammation due to brolucizumab.
Colorectal cancer and advanced adenoma incidence during post-polypectomy surveillance: a national cohort study in the English Bowel Cancer Screening Programme
Authors: Sharp Linda , Rutter Matthew D. , Bonnington Stewart N. , Hungin A. Pali S. , Nickerson Claire , Wright Suzanne 
Published: April 2023

Background Improved colonoscopy quality has led to debate about whether all post-polypectomy surveillance is justified. We evaluated surveillance within the English Bowel Cancer Screening Programme (BCSP) to determine the yield of surveillance and identify predictive factors for surveillance outcome.Methods We performed a retrospective cohort study of individuals undergoing post-polypectomy surveillance between July 2006 and January 2017. BCSP records were linked to the National Cancer Registration Database to identify interval-type post-colonoscopy colorectal cancers (CRCs). Advanced adenoma and CRC at surveillance were documented. CRC incidence was compared with the general population using standardized incidence ratios (SIRs). Predictors of advanced adenomas at first surveillance (S1), and CRC during follow-up, were identified.Results 44 151 individuals (23 078 intermediate risk; 21 073 high risk) underwent 64 544 surveillance episodes. Advanced adenoma and CRC yields were, respectively, 10.0 % and 0.5 % at S1, 8.5 % and 0.4 % at S2, and 10.8 % and 0.4 % at S3. S1 yield was lowest in those with one index adenoma ≥ 10 mm (advanced adenoma 6.1 %; CRC 0.3 %). The SIR was 0.76 (95 %CI 0.66–0.88), accounted for by the intermediate risk group (intermediate risk SIR 0.61, 95 %CI 0.49–0.75; high risk SIR 0.95, 95 %CI 0.79–1.15). Adenoma multiplicity, presence of a large nonpedunculated adenoma, and greater villous component were associated with advanced adenoma at S1. Older age and multiplicity were significantly associated with CRC risk.Conclusion This large, national analysis found low levels of CRC in those undergoing surveillance and low advanced adenoma yield in most subgroups. Less intensive surveillance in some subgroups is warranted, and surveillance may be avoided in those with a single large adenoma.
A Sulfoxide Reagent for Sulfinylative Cross-Coupling
Authors: Saito Fumito 
Published: April 2023

AbstractI recently documented the strategic use of a sulfoxide reagent as a sulfur monoxide equivalent to enable one-pot, three-component syntheses of sulfoxides and sulfinamides. The sulfoxide reagent donates the SO unit upon the reaction with Grignard reagents (RMgX) as sulfenate anions (RSO–). The anionic sulfur intermediates can be readily transformed into sulfoxides and sulfinamides via trapping with appropriate carbon and nitrogen electrophiles. This Synpacts article highlights my first efforts to establish a general sulfinylative cross-coupling platform.1	Introduction2	Development of a Sulfoxide Reagent as a Sulfur Monoxide Equivalent3	Conclusions and Future Directions
Geographical Variation in the Use of Oral Anticoagulation and Clinical Outcomes among Patients with Atrial Fibrillation in Denmark, Sweden, and Finland
Authors: Frost Lars , Halminen Olli , Lehto Mika , Airaksinen K E. Juhani , Andersson Tomas , Wändell Per , Holzmann Martin , Cordsen Pia , Vinter Nicklas , Johnsen Søren Paaske 
Published: April 2023

Abstract
Background Geographical mapping of variations in the treatment and outcomes of a disease is a valuable tool for identifying inequity. We examined international and intranational variations in initiating oral anticoagulation (OAC) therapy and clinical outcomes among patients with atrial fibrillation (AF) in Nordic countries. We also tracked real-world trends in initiating OAC and the clinical outcomes.
Methods We conducted a registry-based multinational cohort study of OAC-naive patients with an incident hospital diagnosis of AF in Denmark (N = 61,345), Sweden (N = 124,120), and Finland (N = 59,855) and a CHA2DS2-VASc score of ≥1 in men and ≥2 in women between 2012 and 2017. Initiation of OAC therapy was defined as dispensing at least one prescription between 90 days before and 90 days after the AF diagnosis. Clinical outcomes included ischemic stroke, intracerebral hemorrhage, intracranial bleeding, other major bleeding, and all-cause mortality.
Results The proportion of patients initiating OAC therapy ranged from 67.7% (95% CI: 67.5–68.0) in Sweden to 69.6% (95% CI: 69.2–70.0) in Finland, with intranational variation. The 1-year risk of stroke varied from 1.9% (95% CI: 1.8–2.0) in Sweden and Finland to 2.3% (95% CI: 2.2–2.4) in Denmark, with intranational variation. The initiation of OAC therapy increased with a preference for direct oral anticoagulants over warfarin. The risk of ischemic stroke decreased with no increase in intracranial and intracerebral bleeding.
Conclusion We documented inter- and intranational variation in initiating OAC therapy and clinical outcomes across Nordic countries. Adherence to structured care of patients with AF could reduce future variation.
Global Research Trends in Endometrial Hyperplasia (2002–2021): A Bibliometric Analysis and Visualization Study
Authors: Mina Angeliki 
Published: April 2023

Abstract
Introduction This article quantifies the research contribution related to endometrial hyperplasia (EH).
Materials and Methods We searched the Scopus database in 2002 to 2021.
Results A total of 6,422 were retrieved; 1,906 were open access; 5,602 in English. The number of published papers showed rising productivity over the last 20 years ranging from 261 to 425. There were 5,034 research articles and 1,388 reviews. The most prolific authors were Zullo, F (30), Mirkin, S (28), Archer, DF (27), and Insabato, L (26). The top involved journals were the Gynecologic Oncology Journal (144), European Journal of Gynaecological Oncology (114), and International Journal of Gynecological Pathology (105). The United States was the most dominant country, with 1,592 articles, followed by China (601) and Italy (435). The most actively involved institutions were the University of Texas MD Anderson Cancer Center (77), followed by Fudan University (63) and Harvard Medical School (62). The top funding sponsors were the National Cancer Institute (178), the National Institutes of Health (177), and the National Natural Science Foundation of China (107). The top three most cited articles received 1,182, 746, and 600 citations, respectively.
Conclusion This study defines the prolific researchers, institutions, journals, and countries as a good starting to bridge gaps in research activity.
Marginal specificity in protein interactions constrains evolution of a paralogous family
Authors: Ghose Dia A. , Przydzial Kaitlyn E. , Mahoney Emily M. , Keating Amy E. , Laub Michael T. 
Published: April 2023

The evolution of novel functions in biology relies heavily on gene duplication and divergence, creating large paralogous protein families. Selective pressure to avoid detrimental cross-talk often results in paralogs that exhibit exquisite specificity for their interaction partners. But how robust or sensitive is this specificity to mutation? Here, using deep mutational scanning, we demonstrate that a paralogous family of bacterial signaling proteins exhibits marginal specificity, such that many individual substitutions give rise to substantial cross-talk between normally insulated pathways. Our results indicate that sequence space is locally crowded despite overall sparseness, and we provide evidence that this crowding has constrained the evolution of bacterial signaling proteins. These findings underscore how evolution selects for “good enough” rather than optimized phenotypes, leading to restrictions on the subsequent evolution of paralogs.
The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation
Authors: Zhu Jiejun , Xian Quanxiang , Hou Xuandi , Wong Kin Fung , Zhu Tingting , Chen Zihao , He Dongming , Kala Shashwati , Murugappan Suresh , Jing Jianing , Wu Yong , Zhao Xinyi , Li Danni , Guo Jinghui , Qiu Zhihai , Sun Lei 
Published: April 2023

Transcranial low-intensity ultrasound is a promising neuromodulation modality, with the advantages of noninvasiveness, deep penetration, and high spatiotemporal accuracy. However, the underlying biological mechanism of ultrasonic neuromodulation remains unclear, hindering the development of efficacious treatments. Here, the well-known Piezo1 was studied through a conditional knockout mouse model as a major mediator for ultrasound neuromodulation ex vivo and in vivo. We showed that Piezo1 knockout (P1KO) in the right motor cortex of mice significantly reduced ultrasound-induced neuronal calcium responses, limb movement, and muscle electromyogram (EMG) responses. We also detected higher Piezo1 expression in the central amygdala (CEA), which was found to be more sensitive to ultrasound stimulation than the cortex was. Knocking out the Piezo1 in CEA neurons showed a significant reduction of response under ultrasound stimulation, while knocking out astrocytic Piezo1 showed no-obvious changes in neuronal responses. Additionally, we excluded an auditory confound by monitoring auditory cortical activation and using smooth waveform ultrasound with randomized parameters to stimulate P1KO ipsilateral and contralateral regions of the same brain and recording evoked movement in the corresponding limb. Thus, we demonstrate that Piezo1 is functionally expressed in different brain regions and that it is an important mediator of ultrasound neuromodulation in the brain, laying the ground for further mechanistic studies of ultrasound.
Responses to English compliments on language ability
Authors: Alharbi Randa Saleh Maine , Strauss Pat , Grant Lynn 
Published: April 2023

Abstract
Employing a cross-generational perspective, this study attempts to deepen our understanding of the politeness
strategies Saudi females use when responding to compliments in English from an English speaker. The study investigated how Saudi
females from two generations respond to compliments in an educational setting in the Kingdom of Saudi Arabia (KSA). Participants
included sixty-two female undergraduate students and sixty-four female lecturers from one university in the KSA. Following a mixed
methods approach, the study included two primary sources of data: a quantitative Discourse Completion Task questionnaire for
eliciting compliment responses (CRs) from the two generations; and qualitative semi-structured interviews with six participants
from each group. Findings indicate that participants from both groups tended to accept compliments although there was a tendency
to question the sincerity of the compliments.
Millennial identity work in BlablaCar online reviews
Authors: Hernández-López María de la O 
Published: April 2023

Abstract
In the age of Internet communication, car sharing as well as other types of sharing (accommodation, offices, etc.)
has led to the emergence of the so-called sharing economy platforms, such as BlaBlaCar. Previous studies have demonstrated that
millennials (i.e., those born between 1981 and 1999) are the most representative generational cohort regarding their interests in
activities organized around BlaBlaCar and similar sites (Činjarević, Kožo and Berberović
2019). One direct consequence of this fact is that the way in which millennials communicate in this particular affinity
space (Gee 2005; Jenkins 2006) may be highly
informative of their discursive identities (Bucholtz and Hall 2005).
Against this backdrop, this study examines 1,000 online reviews taken from www.BlablaCar.es, in order to, first, understand how millennials conceptualize
their experiences in BlaBlaCar; second, examine how identity emerges through labels and implicatures (Bucholtz and Hall 2005); and third, discuss and understand the relationship between the discourse
identity shaped in BlaBlaCar reviews and millennials’ social identity. The findings reveal that BlaBlaCar reviews are highly
informative of users’ identities and their relational needs. Also, these reviews no longer comply with traditional definitions of
‘consumer reviews’, and a re-conceptualization is needed.