bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of number of critical care procedural skill repetitions on supervision level and teaching style
Authors: Zante Bjoern 
Published: January 2023

Background
During critical care procedural skills training (e.g., in intubation and pericardiocentesis) the appropriate supervision level is important to ensure correct use of techniques and guarantee patient safety. The appropriate teaching style should be selected to address residents’ learning behavior and foster their competence. The aim of this study was to explore the number of repetitions for given skills needed to achieve a specified supervision level and a specific teaching style.

Methods
This cross-sectional multicenter survey obtained data from residents and faculty of three multidisciplinary intensive care units (ICU) in Switzerland. Using a 4-point Likert scale, participants were asked to indicate the number of repetitions required to achieve the specified supervision level and teaching style.

Results
Among 91 physicians, the response rate was 64% (n = 59). Their median estimations of the numbers of skill repetitions needed to achieve the final fourth level of supervision and final fourth stage of teaching style were as follows: arterial catheter insertion: supervision level 32, teaching style 17.5; peritoneal paracentesis: supervision level 27, teaching style 17; central venous catheter insertion: supervision level 38, teaching style 28; lumbar puncture: supervision level 38, teaching style 21; endotracheal intubation: supervision level 100, teaching style 45; chest drain insertion: supervision level 27, teaching style 21.5; temporary pacemaker placement: supervision level 50, teaching style 19.5; percutaneous tracheostomy: supervision level 50, teaching style 29; pericardiocentesis: supervision level 50, teaching style 35. Comparison of repetitions between supervision level and teaching style revealed no difference at the first and second levels, except for endotracheal intubation at level 2 (p = 0.03). Differences were observed at the third and fourth levels of supervision level and teaching style (p≤0.04).

Conclusions
It appears that the supervision level and teaching style applied by faculty should change according to both the number of repetitions and the difficulty of critical care procedural skills.
Identification of key ferroptosis genes in diabetic retinopathy based on bioinformatics analysis
Authors: Huang Yan , Peng Jun , Liang Qiuhua 
Published: January 2023

ObjectivesDiabetic retinopathy (DR) is a retinal microvascular disease associated with diabetes. Ferroptosis is a new type of programmed cell death that may participate in the occurrence and development of DR. Therefore, this study aimed to identify the DR ferroptosis-related genes by bioinformatics methods.MethodsThe RNAseq data of DR and healthy control retinas were downloaded from the gene expression synthesis (GEO) database and analyzed using the R package DESeq2. The key modules were obtained using the WGCNA algorithm, and their genes were intersected with ferroptosis-related genes in the FerrDb database to obtain differentially expressed ferroptosis-related genes (DE-FRGs). Enrichment analysis was conducted to understand the function and enrichment pathways of ferroptosis genes in DR, and hub genes were identified by protein-protein interaction (PPI) analysis. The diagnostic accuracy of hub genes for DR was evaluated according to the area under the ROC curve. The TRRUST database was then used to predict the regulatory relationship between transcription factors and target genes, with the mirDIP, ENCORI, RNAnter, RNA22, miRWalk and miRDB databases used to predict the regulatory relationship between miRNAs and target genes. Finally, another data set was used to verify the hub genes.ResultsIn total, 52 ferroptosis-related DEGs (43 up-regulated and 9 down-regulated) were identified using 15 DR samples and 3 control samples and were shown to be significantly enriched in the intrinsic apoptotic signaling pathway, autophagosome, iron ion binding and p53 signaling pathway. Seven hub genes of DR ferroptosis were identified through PPI network analysis, but only HMOX1 and PTGS2 were differentially expressed in another data set. The miRNAs prediction showed that hsa-miR-873-5p was the key miRNA regulating HMOX1, while hsa-miR-624-5p and hsa-miR-542-3p were the key miRNAs regulating PTGS2. Furthermore, HMOX1 and PTGS2 were regulated by 13 and 20 transcription factors, respectively.ConclusionThe hub genes HMOX1 and PTGS2, and their associated transcription factors and miRNAs, may be involved in ferroptosis in diabetic retinopathy. Therefore, the specific mechanism is worthy of further investigation.
Visibility of documentary heritage through digitisation projects in Romanian libraries
Authors: Micle Maria , Tîrziman Elena , Repanovici Angela 
Published: January 2023

Background
The article presents, from a diachronic perspective, the concerns of valorization and preservation of the documentary heritage through digitisation projects in the Romanian Library System. The development of the argument is made starting from the analysis of the interest in the subject in international literature (through a bibliometric analysis) and the investigation of the online presence of libraries expressed statistically from the typology of forms of representation, to specific digital products and services, thus highlighting how they evolved in the sense of diversifying and modernizing the products and services provided and taking into account the political, economic, and technological constraints.

Methods
The evaluation of the involvement of Romanian libraries in digitisation activities was done through the such research methods as content analysis and scientometric research, which allowed the carrying out of a longitudinal case study extended for the period 2007–2022, during the unravelling of the events.

Results
The most representative initiatives for the creation of the Digital Library of Romania and the involvement of libraries in national and European projects are presented, and examples of good practices are highlighted, including political and administrative concerns to support protection and capitalization through the digitisation of the libraries’ heritage. This study is the first in Romanian specialized bibliography that proovides an overall and evolutionary perspective on the national project of digitisation of the documentary cultural heritage. Analyzing a large number of official documents and library web addresses has been a major challenge.

Conclusions
During the analyzed period (2007–2022), there have been numerous initiatives and digitisation projects, but the results have not always met expectations. From the experience of Romanian libraries, it can be concluded that digital content development initiatives have not always been successful because of the absence or insufficient commitment of the sustainability component.
Progesterone and prolactin levels in pregnant women living with HIV who delivered preterm and low birthweight infants: A nested case-control study
Authors: Chi Benjamin H. , Sebikari Dorothy , Brummel Sean S. , DeMarrais Patricia , Chamanga Rachel , Owor Maxensia , Dadabhai Sufia , Price Joan T. , Taha Taha , Stringer Jeffrey , Fowler Mary Glenn 
Published: January 2023

Background
Antiretroviral therapy (ART) is associated with high rates of adverse birth outcomes, including preterm birth and low birthweight. Studies suggest that progesterone and prolactin may play important intermediary roles.

Methods
We analyzed data from the Antenatal Component of the PROMISE trial, a multi-center study of pregnant women taking antiretroviral regimens (lopinavir/ritonavir-containing ART or zidovudine alone) to prevent mother-to-child HIV transmission. In a nested case-control study, we compared data from women who gave birth to preterm (<37 weeks gestation) and/or low birthweight (<2500 g) infants to matched individuals who did not. We measured serum progesterone and prolactin at 24–34 weeks gestation. We used conditional logistic regression to describe relationships between hormone levels, birth outcomes, and antiretroviral regimens.

Results
299 women and their newborns were included (146 cases, 153 controls). When compared to women receiving zidovudine alone, those on ART had higher odds of progesterone levels under the 10th percentile (adjusted odds ratio [AOR]:2.34, 95%CI:1.41–3.89) and 25th percentile (AOR:2.07, 95%CI:1.46–2.94). However, higher levels of progesterone—rather than lower levels—were associated with our composite case outcome at the 10th percentile (AOR:1.88, 95%CI:0.77–4.59) and 25th percentile (AOR:1.96, 95%CI:1.06–3.61). Associations were not observed between prolactin, antiretroviral regimen, and birth outcomes.

Conclusion
We observed lower progesterone levels among women allocated to ART regimens; however, higher progesterone levels were associated with preterm birth and/or low birthweight. While features of the study design may have contributed to these findings, they nevertheless highlight the potentially complex mechanisms underpinning adverse birth outcomes and HIV.
Associations of acute medical care with the transfer and acceptance functions of hospitals in a region in Japan with limited medical resources
Authors: Idaka Takayuki , Iwasa Hajime , Yasumura Seiji 
Published: January 2023

Background
Japan’s health care system may be providing inpatient care inefficiently with a low number of physicians per hospital bed and a long average length of stay (LOS). The present study examined associations of acute medical care with hospital-level factors, such as the transfer and acceptance rates, and mediation effect of LOS, using medical service fees per day as an outcome measure for the provision of acute medical care in hospitals in a region with limited medical resources.

Methods
To analyze the associations of acute medical care with hospital-level factors, this research used multilevel structural equation modeling (SEM) of a dataset that included 225,203 patients admitted to 99 hospitals in Fukushima, Japan. The characteristics of the patients, medical activities, and hospitals, such as the transfer and acceptance rates, were assumed to have both direct and indirect effects through LOS on medical service fees per day.

Results
The final analysis used data from 165,413 patients discharged or transferred from 79 hospitals. After separating patient-level effects using multilevel SEM, the results revealed that, at the hospital level, the transfer rate had a significant and positive association with increased medical service fees per day, both directly (standardized coefficient [SC] = 0.215) and indirectly (SC = 0.057) through shortened LOS. The number of first hospitalized patients per physician had a significant and positive association with increased medical service fees per day only indirectly through shortened LOS (SC = 0.063). The acceptance rate had a significant and negative association with medical service fees per day only indirectly through prolonged LOS (SC = -0.078).

Conclusions
Hospital-level factors, such as enhanced transfer function, reduced acceptance function, and a large number of patients for treatment of acute episodes per physician, had positive associations with increased medical service fees per day, either directly or indirectly through LOS.
Implant angulation and fracture resistance of one-piece screw-retained hybrid monolithic zirconia ceramic restorations
Authors: Bonyatpour Milad , Giti Rashin , Erfanian Behrad 
Published: January 2023

Objective
This study aimed to investigate the fracture resistance of one-piece screw-retained hybrid monolithic zirconia ceramic restorations in different implant angulations.

Materials and methods
Three implant fixtures were embedded in acrylic resin blocks with 0°, 15°, and 25° angulations. For each group of implant angulations, 11 screw-retained one-piece monolithic zirconia restorations were made and bonded to the titanium inserts with a dual-cure self-adhesive resin. The complexes were screwed to the implant fixtures with titanium screws. The samples were thermocycled, subjected to compressive load, and fracture modes were recorded. One-way ANOVA and post hoc Tukey’s test were used for statistical analyses (α = 0.05).

Results
One-way ANOVA showed the fracture resistance to be significanltly different among the study groups (P = 0.036). The 15° group was significantly more resistant than 0° (P = 0.031). However, the 25° group was not significantly different from the 15° (P = 0.203) and 0° groups (P = 0.624). Fractures occurred only on the restorations, not at the screw levels.

Conclusions
Tilting the implant up to 15° improves the fracture resistance of one-piece screw-retained hybrid monolithic zirconia restorations; however, increasing the tilt to 25° would not yield restorations with significantly better fracture strength than the straight implants. Accordingly, when angulated implants are indicated in the esthetic zones, one-piece screw-retained hybrid monolithic zirconia ceramic restorations can be used with acceptable fracture strength.
Distinctive phases and variability of vibration-induced postural reactions highlighted by center of pressure analysis
Authors: Kadri Mohamed Abdelhafid , Bouchard Emilie , Lauzier Lydiane , Mecheri Hakim , Bégin William , Lavallière Martin , Massé-Alarie Hugo , da Silva Rubens A. , Beaulieu Louis-David 
Published: January 2023

BackgroundThe vibration-induced postural reaction paradigm (VIB-PR) offers a unique way for investigating sensorimotor control mechanisms. Measures of VIB-PR are usually calculated from the whole VIB period, yet recent evidence proposed that distinctive mechanisms are likely at play between the early vs. later phases of the postural reaction.ObjectivesThe present work verified if spatiotemporal analyses of center of pressure (COP) displacements can detect differences between these early/later phases of VIB-PR. Also, we further characterized the intra/inter-individual variability of COP measurements, since the underlying variability of VIB-PR remains largely unexplored.MethodsTwenty young volunteers realized two experimental conditions of bipodal stance with eyes closed: (i) bilateral VIB of tibialis anterior (TIB) and (ii) Achilles’ (ACH) tendons. Each condition consisted of five trials and lasted 30 s as follows: 10 s baseline, 10 s VIB and 10 s post-VIB. Linear COP variables (antero-posterior (AP) amplitude & velocity) were computed for both VIB and post-VIB periods using the following time-windows: early 2 s, the later 8 s and the whole 10 s duration. Intra- and inter-individual variability were respectively estimated using the standard error of the measurement and the coefficient of variation. Both variability metrics were obtained using five vs. the first three trials.ResultsSignificant contrasts were found between time-windows for both VIB and post-VIB periods. COP variables were generally higher during the early 2 s phase compared to the later 8 s phase for both TIB [mean difference between 8 s– 2 s phases: Amplitude AP = -1.11 ± 1.14 cm during VIB and -2.99 ± 1.31 during post-VIB; Velocity AP = -1.17 ± 0.86 cm/s during VIB and -3.13 ± 1.31 cm/s during post-VIB] and ACH tendons [Amplitude AP = -0.37 ± 0.98 cm during VIB and -3.41 ± 1.20 during post-VIB; Velocity AP = -0.31 ± 0.59 cm/s during VIB and -3.89 ± 1.52 cm/s during post-VIB]. Most within- and between-subject variability scores were below 30% and using three instead of five trials had no impact on variability. VIB-PR patterns were quite similar within a same person, but variable behaviors were observed between individuals during the later phase.ConclusionOur study highlights the relevance of identifying and separately analyzing distinct phases within VIB-PR patterns, as well as characterizing how these patterns vary at the individual level.
Changes in physical function over time in rheumatoid arthritis patients: A cohort study
Authors: Santo Rafaela Cavalheiro do Espírito , Baker Joshua F. , dos Santos Leonardo Peterson , Silva Jordana Miranda de Souza , Filippin Lidiane Isabel , Portes Juliana Katarina Schoer , Brenol Claiton Viegas , Chakr Rafael Mendonça da Silva , Xavier Ricardo Machado 
Published: January 2023

IntroductionSelf-reported disability is potentially influenced by many factors in patients with rheumatoid arthritis (RA). In this sense, we evaluated the association between self-reported disability and (1) clinical features, (2) muscle strength and (3) physical performance over time among patients with RA from two distinct patient cohorts.Materials and methodsTwo independent prospective RA cohorts were analyzed. The Health Assessment Questionnaire (HAQ), Disease Activity Score in 28 Joints (DAS28), handgrip test, chair stand test, timed-up-and-go (TUG) test and Short Physical Performance Battery (SPPB) were performed at baseline and in follow-up. T test for independent samples, Mann-Whitney U test, Spearman correlation coefficients and linear regression with generalized estimating equations were performed to assess associations between individual constructs at baseline and over time.ResultsA total of 205 total RA patients were included [North American Cohort (n = 115); Brazilian Cohort (n = 90)]. At enrollment, Brazilian men had better HAQ than North American men (p<0.001). Brazilian patients overall had lower muscle strength than North American patients (p<0.05). HAQ was associated with DAS28, handgrip test, chair stand test, TUG and SPPB (p<0.001) in both cohorts. Worsening of the DAS28 and chair stand test were each associated with worsening in HAQ in longitudinal analysis over time. Worsening of handgrip was also associated in with worsening HAQ in both cohorts (p<0.05). A worse TUG test was associated with worsening in HAQ in Brazilian cohort (p<0.05) and a worse SPPB was associated with worsening in HAQ in North American cohort (p<0.05).ConclusionGreater disability measured by HAQ is closely associated with disease activity, pain, muscle strength, and physical performance among RA. Worsening in self-reported disability correlate with worsening clinical factors including objectively-observed physical function.
Public engagement in government officials’ posts on social media during coronavirus lockdown
Authors: Bali Ahmed Omar , Halbusi Hussam Al , Ahmad Araz Ramazan , Lee Ka Yiu 
Published: January 2023

BackgroundSocial media has been a common platform to disseminate health information by government officials during the COVID-19 pandemic. However, little is known about the determinants of public engagement in officials’ posts on social media, especially during lockdown.ObjectivesThis study aims to investigate how the public engages in officials’ posts about COVID-19 on social media and to identify factors influencing the levels of engagement.MethodsA total of 511 adults aged 18 or over completed an online questionnaire during lockdown in Iraq. Levels of engagement in officials’ posts on social media, trust in officials and compliance of government instructions were assessed.ResultsFear of COVID-19 and trust in officials were positively associated with compliance of government instructions. Trust in officials was also associated with active engagement in officials’ posts on social media, including commenting, posting and sharing of the posts.ConclusionsTrust in government has been established during the COVID-19 pandemic. Public engagement in officials’ posts is crucial to reinforce health policies and disseminate health information.
Semilinear heat equation with singular terms
Authors: Ould Khatri Mohamed Mahmoud , Youssfi Ahmed 
Published: January 2023

The main goal of this paper is to analyze the existence and nonexistence as well as the regularity of positive solutions for the following initial parabolic problem

{

∂

t

u
−

Δ

u
=

μ

u

|

x

|

2

+

f

u

σ

in

Ω

T

:=
Ω

×

(
0
,
T
)
,

u
=
0

on

∂

Ω

×

(
0
,
T
)
,

u
(
x
,
0
)
=

u

0

(
x
)

in

Ω

,

where
Ω

⊂

R

N

,
N
≥

3
, is a bounded open,
σ

≥

0
and
μ

>
0
are real constants and
f
∈

L
m

(

Ω

T

)
,
m
≥

1
, and

u
0

are nonnegative functions. The study we lead shows that the existence of solutions depends on
σ

and the summability of the datum
f
as well as on the interplay between
μ

and the best constant in the Hardy inequality. Regularity results of solutions, when they exist, are also provided. Furthermore, we prove uniqueness of finite energy solutions.
Riesgos en el uso del fondo de contingencia ante urgencia manifiesta en la contratación pública en Colombia
Authors: Ortega Saurith Carlos Rodolfo , Correa Martínez César Alberto 
Published: January 2023

El trabajo del legislador en la expedición del Estatuto General de Contratación de la Administración Pública, por medio de la Ley 80 de 1993, hizo referencia en los artículos 42 y 43 a la Urgencia Manifiesta. Así mismo, por medio de la Ley 448 de 1998 se crean y regulan los fondos de contingencias encaminados a cubrir necesidades urgentes derivadas en tres situaciones en particular, siendo una de ellas las obligaciones Contingentes generadas en Contratos Administrativos. El presente artículo tiene como propósito definir y demarcar las clases de riesgos en el uso del fondo de contingencia como ocasión de un imprevisto surgido en la ejecución de contrato de urgencia manifiesta.
El artículo 365 de la Constitución Política de Colombia busca garantizar una asistencia eficiente de los servicios públicos a los habitantes del territorio y, dentro de las obligaciones de las administraciones públicas para el ejercicio de esta obligación, se encuentra la de planear sus actuaciones, especialmente previendo la variedad y tipos de riesgos contractuales. Dentro de los mismos encontramos los ocasionados por hechos previsibles, contrarios a aquellos no previsibles, también los generados por malas prácticas, así como obligaciones contingentes (las provenientes de sentencias judiciales y laudos arbitrales y las provenientes de operaciones de crédito público), entre otros.
Serving and Optimizing Machine Learning Workflows on Heterogeneous Infrastructures
Authors: Wu Yongji , Lentz Matthew , Zhuo Danyang , Lu Yao 
Published: January 2023

With the advent of ubiquitous deployment of smart devices and the Internet of Things, data sources for machine learning inference have increasingly moved to the edge of the network. Existing machine learning inference platforms typically assume a homogeneous infrastructure and do not take into account the more complex and tiered computing infrastructure that includes edge devices, local hubs, edge datacenters, and cloud datacenters. On the other hand, recent AutoML efforts have provided viable solutions for model compression, pruning and quantization for heterogeneous environments; for a machine learning model, now we may easily find or even generate a series of model variants with different tradeoffs between accuracy and efficiency.
We design and implement JellyBean, a system for serving and optimizing machine learning inference workflows on heterogeneous infrastructures. Given service-level objectives (e.g., throughput, accuracy), JellyBean picks the most cost-efficient models that meet the accuracy target and decides how to deploy them across different tiers of infrastructures. Evaluations show that JellyBean reduces the total serving cost of visual question answering by up to 58% and vehicle tracking from the NVIDIA AI City Challenge by up to 36%, compared with state-of-the-art model selection and worker assignment solutions. JellyBean also outperforms prior ML serving systems (e.g., Spark on the cloud) up to 5x in serving costs.