bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reference clock impact on GNSS clock outliers
Authors: Maciuk Kamil , Nistor Sorin , Brusak Ivan , Lewińska Paulina , Kudrys Jacek 
Published: May 2023

Abstract
With the advent of the Global Navigation Satellite System (GNSS), the need for precise and highly accurate orbit and clock products becomes crucial in processing GNSS data. Clocks in GNSS observations form the basis of positioning. Their high quality and stability enable high accuracy and the reliability of the obtained results. The clock modelling algorithms are continuously improved; thus, the accuracy of the clock products is evolving. At present, 8 Analysis Centers (ACs) contribute to the International GNSS Service final clock products. These products are based on GNSS observations on a network of reference stations, where for a given day one of the reference station clocks is the reference clock. In this paper, the authors determined the impact of the reference clock on the quality of clock product, especially outliers, for the first time. For this purpose, the multi-GNSS final clock products provided by the Center for Orbit Determination in Europe (CODE) for the period 2014–2021 (1773–2190 GPS week, 2921 days) were analysed. Analysis shows that by applying the Median Absolute Deviation (MAD) algorithm for outlier detection, the Passive Hydrogen Maser (PHM) clock installed on board the GALILEO satellites have the lowest level of noise, whereas the Block IIR GPS satellite launched in 1999 appears to have the highest levels of noise. Furthermore, the GNSS station OHIE3, when used as a reference clock, generates an increase in the level of noise, especially noticeable on the G09 and E03 satellites.
Jesus’ Descent from the Cross in Ancient and Medieval Reception
Authors: Edwards Robert G. T. 
Published: May 2023

AbstractThis article traces out the receptions of the Gospel accounts of the removal of Jesus from the cross (which has been variously titled the “deposition of Christ” or the “descent from the cross”). This scene is narrated only very briefly in the four canonical Gospels and receives very little attention in the commentary tradition. However, it does receive attention in creative retellings of the Gospel narratives in antiquity and the middle ages; whereas receptions of this scene are less frequent in antiquity, they explode in the high middle ages. Focusing on theGospel of Peter, Nonnus of Panopolis’ poeticParaphrase of John, and the Pseudo-Bonaventuran workMeditationes Vitae Christi, this article explores what might have interested these authors in Jesus’ descent from the cross, and then what these receptions teach us anew about the scene as narrated in the canonical Gospels.
Fasting ketone levels vary by age: implications for differentiating physiologic from pathologic ketotic hypoglycemia
Authors: Parmar Komalben , Mosha Maua , Weinstein David A. , Riba-Wolman Rebecca 
Published: May 2023

Abstract

Objectives
Ketone production is a physiological phenomenon that occurs during beta-oxidation of free fatty acids. Distinguishing physiologic ketosis from pathologic over-production/underutilization of ketones is critical as part of the diagnostic evaluation of disorders of carbohydrate metabolism, but there is limited literature on normal ketone production with fasting. Our aim is to measure fasting serum beta-hydroxybutyrate (BHB) concentrations in healthy children after an overnight fast.

Methods
Children ≤18 years of age were prospectively recruited from elective procedures through our surgery centers. Exclusion criteria included a history of diabetes, hypopituitarism, adrenal, metabolic or inflammatory disorders, dietary restrictions, trauma, or use of medications that might affect blood glucose. Serum glucose, cortisol, and BHB were assessed after an overnight fast.

Results
Data from 94 participants (mean 8.3 ± 5.7 years, 54 % male, 46 % female, were analyzed. Children ≤3 years of age (19) have significantly higher mean (0.40 ± 0.06 mmol/L) and median (0.4, IQR 0.2–0.6 mmol/L) BHB concentrations compared to children >3 years of age (75) with mean (0.21 ± 0.02 mmol/L) and median BHB (0.1, IQR 0.1–0.2 mmol/L) (p<0.0001). Fasting BHB levels of >1.0 mmol/L was rare (2 %, N=2) and 74 % (N=70) of participants had BHB levels <0.3 mmol/L.

Conclusions
BHB concentrations are significantly higher in young children (≤3 years of age) compared to older children. Fasting BHB levels >1.0 mmol/L are rare within our population and therefore may identify a value above which there may a greater concern for pathologic ketotic hypoglycemia. It is imperative to establish the normative range in children to differentiate physiological from pathological ketotic hypoglycemia.
The role of the soluble fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PIGF) – ratio in clinical practice in obstetrics: diagnostic and prognostic value
Authors: Melo Daniela C.S. , Sousa Raquel P. , Pais Maria S.J.D.R. , Felix Luiza M. , Pinto Filipe F. , Moura José P.S.A. 
Published: May 2023

Abstract

Objectives
Analyze the diagnostic and prognostic value of the sFlt-1/PlGF ratio in pregnant women with at least one sign/symptom of suspected/diagnosed pre-eclampsia.

Methods
This retrospective observational study included 170 pregnant women with at least one sign/symptom of pre-eclampsia, who had sFlt-1/PlGF ratio values. The following information was evaluated: pregnant women’s demographic data and clinical history; laboratory data (urine protein/creatinine ratio; sFlt-1/PlGF ratio); signs and symptoms presented; clinical outcome; fetal complications; data related to childbirth. Statistical analysis was performed by R Software Version 3.5.2.

Results
Among the 170 patients, 78 presented pre-eclampsia. The median sFlt-1/PlGF ratio was significantly higher [143.1 (2.2–2,927.1)] for women who presented pre-eclampsia than for women without pre-eclampsia [33.5 (0.8–400.2)]. The negative predictive value of sFlt-1/PlGF ratio <38 was 83.9 % (95 % CI, 71.7–92.4 %) and the positive predictive value of sFlt-1/PlGF ratio >85 or 110 (for late onset pre-eclampsia) was 76.4 % (95 % CI, 66.2–84.8 %). sFlt-1/PlGF >85 or 110 was associated with pre-eclampsia clinical development, fetal complications, shorter gestational age at birth, higher number of caesarean deliveries and lower birth weight.

Conclusions
The sFlt-1/PlGF ratio, together with the standard diagnostic criteria, can be used to rule out pre-eclampsia, identify high-risk patients and predict the occurrence of adverse outcomes.
Predictive value of C-reactive protein-to-albumin ratio for risk of 28-day mortality in patients with severe pneumonia
Authors: Zhang Chi , Zheng Fengxian , Wu Xiaoyong 
Published: May 2023

Abstract

Objectives
To explore the predictive value of C-reactive protein (CRP)-to-albumin (ALB) ratio (CAR) for the risk of 28-day mortality in patients with severe pneumonia.

Methods
A total of 152 patients with severe pneumonia treated from January 2020 to January 2022 were enrolled and assigned into survival group (n=107) and death group (n=45) according to their survival status after treatment for 28 d. Their clinical data were compared, and the influencing factors for 28-day mortality were explored by multiple logistic regression analysis. The receiver operating characteristic (ROC) curve was plotted to assess the value of CAR for predicting 28-day mortality risk. A risk prediction model was constructed, and its prediction efficiency was evaluated.

Results
The death group had significantly older age, Acute Physiology and Chronic Health Evaluation (APACHE) II score, Murray Lung Injury Score, Sequential Organ Failure Assessment score, white blood cell count, neutrophil count, red cell volume distribution width, neutrophil-to-lymphocyte ratio (NLR), fibrinogen, procalcitonin, blood lactic acid (Lac), CRP and CAR and significantly lower oxygenation index and ALB than those of the survival group (p<0.05). APACHE II score, NLR, Lac and CAR were independent risk factors for 28-day mortality (p<0.05). AUC of the established prediction model was 0.826, with sensitivity of 88.45 % and specificity of 87.32 %, indicating high discrimination. The nomogram model had clinical value when the risk threshold probability was 11–93 %.

Conclusions
CAR is an independent risk factor that shows a high predictive value for the 28-day mortality risk in patients with severe pneumonia.
Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis
Authors: Wang Ximin , Zheng Dongxu , Wang Changting , Chen Wanhua 
Published: May 2023

Abstract
Radiotherapy resistance is a challenge for colorectal cancer (CRC) treatment. Circular RNAs (circRNAs) play vital roles in the occurrence and development of CRC. This study aimed to investigate the role of circ_0005615 in regulating the radiosensitivity of CRC. The levels of circ_0005615, microRNA-665 (miR-665), and notch receptor 1 (NOTCH1) were detected by quantitative real-time PCR or western blot. The radiosensitivity of CRC cells was assessed by colony formation assay. Cell viability, apoptosis, and colony formation were assessed by Cell Counting Kit-8 assay, flow cytometry, and colony formation assay. Cell migration and invasion were confirmed by transwell assay and scratch assay. The binding relationship between miR-665 and circ_0005615 or NOTCH1 was verified by dual-luciferase reporter assay. Xenograft assay was used to test the effect of circ_0005615 on radiosensitivity in vivo. circ_0005615 and NOTCH1 were up-regulated, and miR-665 was down-regulated in CRC tissues and cells. Radiation decreased circ_0005615 and NOTCH1 levels and increased miR-665 level. Knockdown of circ_0005615 enhanced radiosensitivity of CRC cells. Moreover, circ_0005615 sponged miR-665 to regulate the radioresistance of CRC cells. Besides, miR-665 targeted NOTCH1 to mediate the radiosensitivity of CRC cells. Furthermore, circ_0005615 depletion increased CRC radiosensitivity in vivo. circ_0005615 silencing elevated radiosensitivity of CRC by regulating miR-665/NOTCH1 axis.
“Farewell My Sweet Virginia” – “Die, Die Lavinia”: Defiled Roman Maidens in Webster and Heywood’s Appius and Virginia and Shakespeare’s Titus Andronicus
Authors: Di Maio Myriam 
Published: May 2023

Abstract
The relentless contribution of women’s studies and feminist theory has shaped current academic and cultural perceptions of such a controversial subject as rape, which up to this day has received a fair share of attention but which will never cease to stimulate research, nor satisfy our enquiries. This paper aims to provide an analysis of literary and legal responses to this issue in two near contemporary tragedies: Titus Andronicus by William Shakespeare and Appius and Virginia by John Webster and Thomas Heywood, a work awaiting critical consideration. The plays present diegetic and mimetic similarities and are bound by a strong intertextuality which refers to their common sources. The paper also investigates those issues relating to the visual representation and the verbal transmission of rape, problems which feature in earlier and contemporary legal statutes.
Worlds Falling Apart: Human and Nonhuman in Jeanette Winterson’s The Stone Gods
Authors: Volpone Annalisa 
Published: May 2023

Abstract
This essay discusses Jeanette Winterson’s The Stone Gods (2007) in light of human and nonhuman relationships. The author presents us with quite a paradoxical situation, whereby what is human seems to be less human than what is said to be nonhuman. The ontological instability produced by such a peculiar paradigm generates interesting consequences in terms of fundamental rights, especially when applied to hybrid forms of life such as those represented by “Robo sapiens.” Hence, Winterson’s novel invites a reconfiguration of the notion of rights and “legal personhood” in the context of AI systems. Robots demand that their “humanity” is acknowledged and, as a consequence to that, they also demand that they are granted rights. One could notice that Robot’s existential condition is very similar to that of slaves, precisely like slaves they are submitted to servitude, forced or bonded labour. And yet the fact that they are not “fully human”, only very similar or close to them, puts robots in a juridical position that might be compared to that of animals and the way they are presented in animal law studies.
Electrosprayed low toxicity polycaprolactone microspheres from low concentration solutions
Authors: Syed Jaafar Sharifah Nabihah , Zambari Izzah Farhah , Amini Nur Alia Irdina , Norizan Balqis Az-Zahraa , Daud Muhammad Fauzi 
Published: May 2023

Abstract
This work describes the successful tunable production of polycaprolactone (PCL) microspheres using very low-concentration solutions. The PCL solutions (1, 3, and 5 w/v%) were prepared with different solvents (dichloromethane (DCM) and chloroform (CHL)) and electrosprayed at different distances (5, 10, and 15 cm). The solubility and viscosity of PCL solutions were in accordance with the polymer concentrations, demonstrating PCL-DCM gave a higher solubility of PCL, but PCL-CHL solutions had a higher viscosity. Optical microscopy (OM) and field emission-scanning electron microscopy (FE-SEM) revealed that the PCL-DCM preparations produced a smaller and more uniform microsphere size and pore size compared to PCL-CHL microspheres. The linear regression analysis showed that the solubility and viscosity of PCL concentration influence the size of microspheres more greatly than the pore size. The toxicity results indicated that PCL-CHL and PCL-DCM are well-tolerated by zebrafish embryos that were able to follow a normal growth pathway and can thus be deemed safe.
Insubordination, oder: Gewalt gegen sich selbst als paradoxe Intervention in soziale Systeme
Authors: Simon Fritz B. 
Published: May 2023

Zusammenfassung
Wenn die Möglichkeit zur Anwendung von Gewalt Grundlage von Machtbeziehungen ist, so stellt sich die Frage, welche Folgen es für Machtbeziehungen hat, wenn ein Individuum Gewalt gegen den eigenen Körper ausübt (von der Selbstverletzung bis zum Suizid). Die exemplarische Untersuchung verschiedener Typen sozialer Systeme (Staaten, Organisationen, Religionsgemeinschaften, Familien …) zeigt, dass autoaggressive Handlungen unterschiedliche soziale Wirkungen entfalten, je nachdem, ob sie öffentlich oder heimlich ausgeführt werden und wie sie erklärt werden (individuelle Pathologie vs. politische Demonstration). Diese Art der Gewaltanwendung wirkt in den jeweiligen sozialen Systemen als paradoxe Intervention. Die Drohung mit Gewalt als Grundlage von Macht verpufft, wenn die Gewalt von dem Bedrohten autonom an sich selbst vollzogen wird. Dies kann etablierte Machtstrukturen in Frage stellen, wenn es öffentlich erfolgt und als Akt des politischen Widerstands interpretiert wird.
Violence from the perspective of social immunology: a contribution to social systems theory
Authors: Tosini Domenico 
Published: May 2023

AbstractThis paper analyzes violence from the peculiar perspective of a “social immunology”, defined as the area of social systems theory concerned primarily, even though not exclusively, with those processes by which social systems as communication systems deal with tensions, termed ecological tensions, that involve the intersection between social systems and their human environment and that endanger the maintenance of social autopoiesis. Individuals’ violent behaviors are manifestations of such tensions. However empirically ubiquitous it may be, violence constitutes a crucial problem for social systems, due to risks detrimental to the human substrate of communicative processes. We theorize about conflicts, social movements and the legal system as the main components of an immune apparatus of social systems by focusing on individuals’ reactions to social costs and related social conflicts. Modern law, in particular, tends to promote individuals’ inclusion and to restrain their resorting to violence by relying on a system of rights, procedures, and judicial institutions conducive to attracting and regulating such conflicts. Legal immunization remains nonetheless exposed to several limitations, including abnormal forms that concur to the arbitrary use of violence.
Diante das cisões: cinema e luta por moradia
Authors: Lima Érico Araújo 
Published: May 2023

O artigo discute a relação entre cinema e práticas moradoras. Primeiro, situa uma questão larga, a íntima relação entre cinema e morada. Em seguida, enfatiza a luta por moradia e o engajamento face a cisões na nossa experiência social. Propomos um cotejo entre os filmes: A cidade é uma só? (2011), de Adirley Queirós, e Na Missão, com Kadu (2016), de Pedro Maia de Brito, Aiano Bemfica e Kadu Freitas. Sublinhamos as articulações entre o cinema e a ação política diante das violências perpetradas pelo Estado às condições de moradia de populações.Palavras-chave: Morada; Moradia; Cisões; Cinema. Before Splitting: Cinema and the Struggle for Housing Abstract: The article discusses the relationship between cinema and dwelling practices. First, it poses a broad question, the intimate relationship between cinema and dwelling. It then emphasizes the struggle for housing and the engagement in the face of splits in our social experience. We propose a comparison between the f ilms: A cidade é uma só? (2011), de Adirley Queirós, and Na missão, com Kadu (2016), de Pedro Maia de Brito, Aiano Bemf ica, Kadu Freitas. We emphasize the articulations between cinema and political action in the face of violence perpetrated by the State on the housing conditions of populations. Keywords: Dwelling; Housing; Splits; Cinema.
Rice flour coating supplemented with rosemary essential oil to preserve the internal, microbiological, and sensory quality of quail eggs
Authors: Oliveira G.d.S. , McManus C. , Salgado C.B. , Pires P.G.d.S. , dos Santos V.M. 
Published: May 2023

AbstractCoatings of rice flour (RF), reinforced or not with rosemary essential oil (ROS), were used to evaluate changes in the internal quality of quail eggs stored at room temperature. Quality parameters [egg weight loss (EWL, %), Haugh unit (HU), yolk index (YI), albumen and yolk pH], microbiological (counts of total aerobic mesophilic bacteria and Enterobacteriaceae) and sensory (colour, aroma, odour, texture, taste, and general acceptability) parameters were evaluated during the experiment. Compared to the number of total aerobic mesophilic bacteria on the shell of uncoated eggs (2.02 ± 0.49; 1.78 ± 0.20 log10 CFU mL−1), RF/ROS exhibited significant inhibition effects for these bacteria on 0. (1.16 ± 0.25 log10 CFU mL−1) and 21. (0.84 ± 0.11 log10 CFU mL−1) days of storage at room temperature. On days 7, 14, and 21, RF had no effect on HU (P > 0.05), but eggs coated with RF/ROS had significantly higher HU (P < 0.05) than uncoated eggs from day 14, maintaining grade AA (73.88 ± 2.67) on day 21, while uncoated eggs had grade A (68.90 ± 1.55) at that time. The RF coating reinforced with ROS was a bioactive, efficient, and safe formulation for application based on internal quality, microbiological and sensorial aspects of quail eggs.
Relationship between the left atrial and pulmonary vein effective refractory period and the development of early atrial fibrillation recurrence after radiofrequency pulmonary vein isolation. First results
Authors: Kozhenov A. T. , Azizov S. N. , Khlynova O. V. 
Published: May 2023

Aim. To assess the relationship between the left atrial (LA) and pul­monary vein (PV) effective refractory period and the development of early atrial fibrillation (AF) recurrence after radiofrequency pul­monary vein isolation (PVI).Material and methods. The study included 35 patients with persistent AF refractory to antiarrhythmic therapy (AAT). In all patients, LA and PV effective refractory period (ERP) was assessed, followed by radiofrequency antral PVI. Depending on the ERP values, the patients were divided into 2 groups. Group 1 (n=15) included patients with mean LA and PV ERP values ≥240 ms, while group 2 (n=20) consisted of patients with mean LA and PV ERP values <240 ms. The evaluation of early AF recurrence, depending on the obtained ERP values, was carried out in the first 3 months.Results. We obtained following ERP values: group 1 — LA (LA ap­ pendage) 252±8,9 ms; left superior PV (LSPV) — 252±12,1 ms; left inferior PV (LIPV) — 257,3±8,15 ms; right superior PV (RSPV) — 254,6±11,3 ms; right inferior PV (RIPV) — 260±9,05 ms; group 2 — LA 230±12,1 ms; LSPV — 205±10,5 ms; LIPV — 186,6±22,05 ms; RSPV — 212,2±14 ms; RIPV — 218,8±11,1 ms. During the 3-month follow-up of group 1 patients, there were no recurrences after PVI. Group 2 had 7 early AF recurrences. Correlation analysis revealed a significant inversely proportional relationship (-0,349; p=0,03) between ERP values and the recurrence rate in the groups.Conclusion. The first results demonstrate an inversely proportional relationship between the mean PV and LA ERP and the development of early AF recurrence, which makes it possible to consider the PV and LA ERP <240 ms as a likely predictor of early AF recurrence. However, this fact requires the study continuation with an increase in the sample and an appropriate statistical analysis.
In search of the oldest rock of Austria: The Hauergraben Gneiss, a 1.40 Ga old mafic quartz-monzonitic inlayer in the Dobra Gneiss (Drosendorf Unit, Bohemian Massif) as a new candidate
Authors: Lindner Martin , Dörr Wolfgang , Hauzenberger Christoph A. , Reither Daniel , Finger Fritz 
Published: May 2023

Abstract
For a long time, the 1.38 Ga old Dobra Gneiss (Type A) from the Lower Austrian Drosendorf Unit (Moldanubian Zone, Bohemian Massif) was considered the oldest rock of Austria. We now have dated zircons from a local mafic inlayer in the Dobra Gneiss Type A, termed Hauergraben Gneiss. This small-scale amphibole-bearing orthogneiss has a magmatic formation age of 1.40 Ga, and is, thus, to the present state of knowledge, the oldest rock of Austria. Based on geochemical investigations, the protolith of the Hauergraben Gneiss was a quartz-monzonite. It probably originated in a volcanic arc setting like the Dobra Gneiss, but shows distinctively higher transitional metal contents (especially Cr and Co), higher Ba and Sr, and higher light rare earth element contents, which hint at a lithospheric mantle input. This 1.40 Ga old mafic arc material was then incorporated into the 1.38 Ga old intrusive protolith of the Dobra Gneiss, probably in the form of enclaves. Considering the model that the Drosendorf Unit was part of Amazonia until the late Neoproterozoic, we propose that both, Dobra Gneiss Type A and Hauergraben Gneiss, originated at the western margin of the Columbia super-continent, where several long-lived Mesoproterozoic volcanic arcs existed and accreted over time. During the Variscan orogeny, the Hauergraben Gneiss experienced peak metamorphic temperatures of ~620 °C at pressures of ~6 kbar, as can be deduced from amphibole thermobarometry. This is in line with published peak-PT estimates from other parts of the Drosendorf Unit. Formation of secondary low-Al magnesiohornblende at the expense of the earlier edenitic/pargasitic peak amphibole indicates a subsequent retrograde overprint.