bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutational analysis of DNMT3A improves the prognostic stratification of patients with acute myeloid leukemia
Authors: Wakita Satoshi , Marumo Atsushi , Morita Kaoru , Kako Shinichi , Toya Takashi , Najima Yuho , Doki Noriko , Kanda Junya , Kuroda Junya , Mori Shinichiro , Satake Atsushi , Usuki Kensuke , Ueki Toshimitsu , Uoshima Nobuhiko , Kobayashi Yutaka , Kawata Eri , Nakayama Kazutaka , Nagao Yuhei , Shono Katsuhiro , Shibusawa Motoharu , Tadokoro Jiro , Hagihara Masao , Uchiyama Hitoji , Uchida Naoyuki , Kubota Yasushi , Kimura Shinya , Nagoshi Hisao , Ichinohe Tatsuo , Kurosawa Saiko , Motomura Sayuri , Hashimoto Akiko , Muto Hideharu , Sato Eriko , Ogata Masao , Mitsuhashi Kenjiro , Ando Jun , Tashiro Haruko , Sakaguchi Masahiro , Yui Shunsuke , Arai Kunihito , Kitano Tomoaki , Miyata Miho , Arai Haruka , Kanda Masayuki , Itabashi Kako , Fukuda Takahiro , Kanda Yoshinobu , Yamaguchi Hiroki 
Published: January 2023

AbstractNucleophosmin1 (NPM1) mutations are the most frequently detected gene mutations in acute myeloid leukemia (AML) and are considered a favorable prognostic factor. We retrospectively analyzed the prognosis of 605 Japanese patients with de novo AML, including 174 patients with NPM1‐mutated AML. Although patients with NPM1‐mutated AML showed a high remission rate, this was not a favorable prognostic factor for overall survival (OS); this is contrary to generally accepted guidelines. Comprehensive gene mutation analysis showed that mutations in codon R882 of DNA methyltransferase 3A (DNMT3AR882 mutations) were a strong predicative factor indicating poor prognosis in all AML (p < 0.0001) and NPM1‐mutated AML cases (p = 0.0020). Furthermore, multivariate analysis of all AML cases showed that DNMT3AR882 mutations and the co‐occurrence of internal tandem duplication in FMS‐like tyrosine kinase 3 (FLT3‐ITD), NPM1 mutations, and DNMT3AR882 mutations (triple mutations) were independent factors predicting a poor prognosis related to OS, with NPM1 mutations being an independent factor for a favorable prognosis (hazard ratios: DNMT3AR882 mutations, 1.946; triple mutations, 1.992, NPM1 mutations, 0.548). Considering the effects of DNMT3AR882 mutations and triple mutations on prognosis and according to the classification of NPM1‐mutated AML into three risk groups based on DNMT3AR882/FLT3‐ITD genotypes, we achieved the improved stratification of prognosis (p < 0.0001). We showed that DNMT3AR882 mutations are an independent factor for poor prognosis; moreover, when confounding factors that include DNMT3AR882 mutations were excluded, NPM1 mutations were a favorable prognostic factor. This revealed that ethnological prognostic discrepancies in NPM1 mutations might be corrected through prognostic stratification based on the DNMT3A status.
Owners' nonfinancial objectives and the diversification and internationalization of business groups
Authors: Cuervo‐Cazurra Alvaro , Colpan Asli M. 
Published: January 2023

AbstractResearch Question/IssueStudies on business groups, a collection of legally separate firms operating in unrelated industries under common control, tend to compare the behavior of firms affiliated with business groups and firms that are independent companies. Unfortunately, this ignores the diversity among business groups based on their controlling owner. Hence, in this conceptual article, we study how the types of controlling owners impact the diversification and internationalization of business groups.Research Findings/InsightsBuilding on agency theory, we separate business groups into five types based on their ultimate controlling owners (state, labor, family, mutual, and bank) and identify their nonfinancial objectives. We argue that their nonfinancial objectives result in diverging levels of diversification and internationalization of business groups across owner types. Specifically, we propose that state‐owned and bank‐owned business groups have a relatively high level of diversification, labor‐owned and mutual‐owned business groups have a relatively moderate level, and family‐owned business groups have a relatively low level. We also argue that state‐owned and labor‐owned business groups have a relatively low level of internationalization, family‐owned business groups have a relatively moderate level, and mutual‐owned and bank‐owned business groups have a relatively high level. We add depth to these ideas by proposing that pro‐market reforms alter owners' ability to achieve their nonfinancial objectives, leading to diverging changes in business groups' diversification and internationalization across owner types. Specifically, we propose that following pro‐market reforms, state‐owned and bank‐owned business groups experience a large decrease in their level of diversification, labor‐owned and mutual‐owned business groups see a moderate decrease, and family‐owned business groups have a small decrease. We also argue that pro‐market reforms lead state‐owned and labor‐owned business groups to have a small increase in their level of internationalization, family‐owned a moderate increase, and mutual‐owned and bank‐owned to experience a large increase.Theoretical/Academic ImplicationsTo the business groups literature, we highlight the importance of controlling owners and their nonfinancial objectives as the drivers of business group diversification and internationalization, complementing the usual focus on market imperfections. To agency theory, we highlight the diversity of owners' nonfinancial objectives and explain how these affect strategy, complementing the traditional focus on differences in objectives between owners and professional managers driving strategy.Practitioner/Policy ImplicationsManagers can defend decisions based on the often‐unstated nonfinancial objectives of the controlling owners, countering external investors' criticisms of managers misbehaving by not aiming to maximize profits.
Clinical usefulness of end‐tidal CO2 measured using a portable capnometer in patients with respiratory disease
Authors: Suzuki Manabu , Fujimoto Shota , Sakamoto Keita , Tamura Kentaro , Ishii Satoru , Iikura Motoyasu , Izumi Shinyu , Takeda Yuichiro , Hojo Masayuki , Sugiyama Haruhito 
Published: January 2023

AbstractIntroductionThis study aimed to evaluate the correlation and agreement between end‐tidal CO2 (EtCO2) measured with the novel portable capnometer (CapnoEye®) and partial pressure of arterial carbon dioxide (PaCO2) levels in patients with respiratory diseases and to compare the efficacy of EtCO2 and PvCO2 in predicting PaCO2 levels.MethodsWe analyzed the correlation and the agreement between EtCO2 and PaCO2 and between PvCO2 and PaCO2 using Pearson's moment correlation coefficient in patients with type 1 and type 2 respiratory failure and both groups overall.ResultsA total of 100 samples were included that comprised 67 men (67%). The mean age of the subjects was 77 ± 13 years. Chronic obstructive pulmonary disease (COPD) (43%) was the most common disease. There was a high correlation between EtCO2 and PaCO2 (r = 0.88; p < 0.0001). Sixty‐six PvCO2 samples were obtained, and there was a high correlation between PvCO2 and PaCO2 (r = 0.81; p < 0.0001). Regarding type 2 respiratory failure, there was a high correlation between EtCO2 and PaCO2 (r = 0.81). The Bland–Altman analysis between PaCO2 and EtCO2 revealed a bias of 5.7 mmHg, with limits of agreement ranging from −5.1 mmHg to 16.5 mmHg. In contrast, the analysis between PaCO2 and PvCO2 revealed a bias of −6.8 mmHg, and the limits of agreement ranged from −22.13 mmHg to 8.53 mmHg.ConclusionEtCO2 measured by CapnoEye® was significantly correlated to PaCO2 levels in patients with respiratory diseases. Moreover, CapnoEye® may be more useful for predicting hypercapnia conditions in which respiratory diseases are compared with measure PvCO2.
Helical structure of the ventricular myocardium. A narrative review of cardiac mechanics
Authors: Antúnez‐Montes Omar Yassef , Kocica Mladen J. , Olavarria Alberto Sosa , Corno Antonio Francesco , Millan Rocio Aceves , Rosales Carlos Ixcamparij , Sanchez Aparicio Hector Eduardo 
Published: January 2023

AbstractTo date, the ventricular myocardial band is the anatomical‐functional model that best explains cardiac mechanics during systolic‐diastolic phenomena in the cardiac cycle. The implications of the model fundamentally affect the anatomical interpretation of the ventricular myocardium, giving meaning to the direction that muscle fibers take, turning them into an object of study with potential clinical, imaging, and surgical applications. Re‐interpreting the anatomy of the ventricular muscle justifies changes in the physiological interpretation, from its functional focus as a fiber unraveling the mechanical phenomena carried out during systole and diastole. We identify the functioning of the heart from the electrical and hemodynamic point of view, but it is necessary to delve into the mechanics that originate the hemodynamic changes observed flowmetrically, and that manifested during the pathology. In this review, the mechanical phenomena that the myocardium performs in each phase of the cardiac cycle are broken down in detail, emphasizing the physical displacements that each of the muscle segments presents, as well as a vision of their alteration and in which pathologies they are mainly identified. Visually, an anatomical correlation to the echocardiogram is provided, pointing out the direction of the segmental myocardial displacement by the strain velocity vector technique.
Results from a test‐and‐treat study for influenza among residents of homeless shelters in King County, WA: A stepped‐wedge cluster‐randomized trial
Authors: Rogers Julia H. , Casto Amanda M. , Nwanne Gift , Link Amy C. , Martinez Miguel A. , Nackviseth Callista , Wolf Caitlin R. , Hughes James P. , Englund Janet A. , Sugg Nancy , Uyeki Timothy M. , Han Peter D. , Pfau Brian , Shendure Jay , Chu Helen Y. 
Published: January 2023

AbstractBackgroundPersons experiencing homelessness face increased risk of influenza as overcrowding in congregate shelters can facilitate influenza virus spread. Data regarding on‐site influenza testing and antiviral treatment within homeless shelters remain limited.MethodsWe conducted a cluster‐randomized stepped‐wedge trial of point‐of‐care molecular influenza testing coupled with antiviral treatment with baloxavir or oseltamivir in residents of 14 homeless shelters in Seattle, WA, USA. Residents ≥3 months with cough or ≥2 acute respiratory illness (ARI) symptoms and onset <7 days were eligible. In control periods, mid‐nasal swabs were tested for influenza by reverse transcription polymerase chain reaction (RT‐PCR). The intervention period included on‐site rapid molecular influenza testing and antiviral treatment for influenza‐positives if symptom onset was <48 h. The primary endpoint was monthly influenza virus infections in the control versus intervention periods. Influenza whole genome sequencing was performed to assess transmission and antiviral resistance.ResultsDuring 11/15/2019–4/30/2020 and 11/2/2020–4/30/2021, 1283 ARI encounters from 668 participants were observed. Influenza virus was detected in 51 (4%) specimens using RT‐PCR (A = 14; B = 37); 21 influenza virus infections were detected from 269 (8%) intervention‐eligible encounters by rapid molecular testing and received antiviral treatment. Thirty‐seven percent of ARI‐participant encounters reported symptom onset < 48 h. The intervention had no effect on influenza virus transmission (adjusted relative risk 1.73, 95% confidence interval [CI] 0.50–6.00). Of 23 influenza genomes, 86% of A(H1N1)pdm09 and 81% of B/Victoria sequences were closely related.ConclusionOur findings suggest feasibility of influenza test‐and‐treat strategies in shelters. Additional studies would help discern an intervention effect during periods of increased influenza activity.
A bottom‐up ontology‐based approach to monitor circular economy: Aligning user expectations, tools, data and theory
Authors: Sileryte Rusne , Wandl Alexander , van Timmeren Arjan 
Published: January 2023

AbstractWith circular economy being high on governmental agendas, there is an increasing request from governing bodies for circularity measurements. Yet, currently existing macro‐level monitoring frameworks are widely criticized for not being able to inform the decision‐making. The criticism includes, among others, a lack of consensus on terminologies and definitions among scholars, politicians, and practitioners, a lack of supporting data and tools and, consequently, a lack of transparency and trustworthiness. To address those needs, a bottom‐up approach to build a shared terminology is suggested as a starting point for monitoring development. The government, data providers, and tool developers are involved in the process of formal ontology development and alignment. The experiment builds upon a use case of the Amsterdam Circular Economy Monitor (2020). First, four ontology development approaches are used to create a theory‐centered, a user‐centered, a tool‐centered, and a data‐centered ontology. The ontologies are later compared, merged, and aligned to arrive at one single ontology which forms the basis of the circular economy monitor. The notes taken during the process have revealed that next to a material flow model, typical of socioeconomic metabolism analysis, policy makers are concerned with actors (i.e., institutions, companies, or groups of people) who participate in the analyzed processes and services. Furthermore, a number of terms used by the decision‐makers lack clear definitions and references to be directly associated with the available data. Finally, a structured terminology alignment process between monitor users, developers, and data providers helps in exposing terminology conflicts and ambiguities.
When does upcycling mitigate climate change? The case of wet spent grains and fruit and vegetable residues in Canada
Authors: Jain Sourabh , Gualandris Jury 
Published: January 2023

AbstractWe investigate when upcycling—defined as treating food by‐products for human consumption—mitigates climate change. Earlier research only modeled pilot‐scale upcycling experiments, which discount its real‐world complexity. To tackle this important limitation, our research involved 130 interviews, life cycle assessment, and a simulation to assess what operational structures made upcycling environmentally sustainable and superior to alternatives such as animal feeding, anaerobic digestion, composting, and landfilling. We considered wet spent grains and fruit and vegetable residues in Canada, two important streams of unavoidable residuals in Western food systems. First, we found that the simulated range of greenhouse gas impacts, +938 to −465 kg of CO2 eq. emissions per tonne of upcycled material, was more optimistic than the ranges available in the literature. No previous estimates existed for the range of impacts for real cases, −18 and −300 kg of CO2 eq. emissions per tonne of upcycled material. Second, net‐negative carbon impacts were achieved only by operational structures with a technological configuration characterized by a total energy consumption lower than 1500 kWh per tonne of upcycled materials and a geographical scale inferior to 260 km (from point of collection to point of sale). Most of the real cases identified during our fieldwork matched these operational prescriptions and achieved a carbon footprint up to 25% smaller than the carbon footprint of the substituted virgin products. Third, our analysis of both best‐case simulated performance and real performance suggested that the positive carbon impact of upcycling was roughly comparable with that produced by animal feeding and anaerobic digestion, but superior to composting and landfilling. Our study illuminates the anatomy of environmentally sustainable upcycling operations and problematizes emergent food recovery hierarchies.
Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia
Authors: Glanemann Barbara , Humm Karen , Abreu Mariana , Aspinall Sophie , Buckeridge David , Carveth Hope , Darcy Hannah , Florey Jessica , Frowde Polly , Gajanayake Isuru , Green Kate , Holmes Emma , Hrovat Alenka , Jasensky Anne‐Katherine , Jones Bryn A , Lantzaki Vasiliki , Lo Eve JY , MacDonald Kirsty , O'Brien Kevin , Suárez‐Bonnet Alejandro , Van den Steen Nele , Szladovits Balazs , Willems Annelies , Wilson Helen 
Published: January 2023

AbstractBackgroundAfter a strong epidemiological link to diet was established in an outbreak of pancytopenia in cats in spring 2021 in the United Kingdom, 3 dry diets were recalled. Concentrations of the hemato‐ and myelotoxic mycotoxins T‐2, HT‐2 and diacetoxyscirpenol (DAS) greater than the European Commission guidance for dry cat foods were detected in the recalled diets.ObjectivesTo describe clinical and clinicopathological findings in cats diagnosed with suspected diet induced pancytopenia.AnimalsFifty cats presenting with pancytopenia after exposure to a recalled diet.MethodsMulticenter retrospective case series study. Cats with known exposure to 1 of the recalled diets were included if presented with bi‐ or pancytopenia and underwent bone marrow examination.ResultsCase fatality rate was 78%. Bone marrow aspirates and biopsy examination results were available in 23 cats; 19 cats had a bone marrow aspirate, and 8 cats had a biopsy core, available for examination. Bone marrow hypo to aplasia—often affecting all cell lines—was the main feature in all 31 available core specimens. A disproportionately pronounced effect on myeloid and megakaryocytic cells was observed in 19 cats. Myelofibrosis or bone marrow necrosis was not a feature.Conclusion and Clinical ImportanceMycotoxin induced pancytopenia should be considered as differential diagnosis in otherwise healthy cats presenting with bi‐ or pancytopenia and bone marrow hypo‐ to aplasia.
An investigation into an outbreak of pancytopenia in cats in the United Kingdom
Authors: Glanemann Barbara , Humm Karen , Pegram Camilla , Chan Daniel L. 
Published: January 2023

AbstractBackgroundIn spring 2021 increasing numbers of cats presenting with severe pancytopenia were noted in United Kingdom (UK).ObjectiveTo describe process and outcome of the investigation performed into the outbreak of pancytopenia in cats.AnimalsFive hundred and eighty client owned cats that presented with severe bi‐ or pancytopenia of unknown cause.MethodsReal‐time data collection was performed by an online registration forum available to all veterinary surgeons in UK. Data collected included demographics, clinicopathological findings, diagnostic testing, dietary and drug history, outcome and COVID household status. Mycotoxicological feed analysis was performed on feed samples of 3 diets frequently mentioned in the database and 3 control diets.ResultsFive hundred and eighty cats presented to 378 veterinary practices were included for analysis. Case fatality rate was 63.3%. Dietary history was available for 544 (93.8%) cats, of which 500 (86%) were fed 1 of 3 diets (which were recalled midinvestigation). 54 (9.3%) cats were not fed a recalled product, with diet information unknown in 26 (4.5%) cats. Analysis of feed samples revealed concentrations of hematotoxic trichothecene T‐2/HT‐2 mycotoxins greater than recommended by the European Commission in 5/7 recalled diet samples but in none of control diet samples. The trichothecene mycotoxin diacetoxyscirpenol (DAS) was detectable in all recalled diet samples but not in any of control samples.Conclusion and Clinical ImportanceContaminated‐feed induced trichothecene mycotoxicosis should be considered as a differential diagnosis for pancytopenia in cats.
Menopausal hormone therapy and the risk of cataracts in postmenopausal women in South Korea
Authors: Yuk Jin‐Sung , Park Jae Yong , Sim Ha Eun , Hwang Je Hyung 
Published: January 2023

AbstractPurposePostmenopausal women have a higher prevalence of cataracts than men of a similar age. This study aimed to evaluate the effects of menopausal hormone therapy (MHT) on lens opacities in postmenopausal women.MethodsThis retrospective cohort study analysed population‐based health insurance data in South Korea collected from 2002 to 2019. To determine the risk factors associated with cataract, postmenopausal women (N = 2,506,271) were grouped according to post‐MHT use. The treatment group was further divided into the following subgroups: tibolone, combined oestrogen plus progestin by manufacturer, oral oestrogen, combined oestrogen plus progestin by physician and topical oestrogen groups. The main outcome measure was the prevalence of cataracts.ResultsThe control group comprised 463,151 postmenopausal women who had never used MHT after menopause, while the treatment group included 228,033 postmenopausal women who had used MHT continuously for at least 6 months. The treatment group had a higher incidence of cataracts than the control group based on Cox proportional hazards ratio analysis. Low socioeconomic status and high parity were identified as risk factors for cataracts, and reduced risk of cataracts was associated with living in rural areas and drinking alcohol.ConclusionsWomen undergoing post‐MHT, including tibolone, had a higher incidence of cataracts. Cataract development should be a concern when examining postmenopausal patients using MHT.
Host‐ and virus‐induced gene silencing of HOG1‐MAPK cascade genes in Rhizophagus irregularis inhibit arbuscule development and reduce resistance of plants to drought stress
Authors: Wang Sijia , Xie Xianan , Che Xianrong , Lai Wenzhen , Ren Ying , Fan Xiaoning , Hu Wentao , Tang Ming , Chen Hui 
Published: January 2023

SummaryArbuscular mycorrhizal (AM) fungi can form beneficial associations with the most terrestrial vascular plant species. AM fungi not only facilitate plant nutrient acquisition but also enhance plant tolerance to various environmental stresses such as drought stress. However, the molecular mechanisms by which AM fungal mitogen‐activated protein kinase (MAPK) cascades mediate the host adaptation to drought stimulus remains to be investigated. Recently, many studies have shown that virus‐induced gene silencing (VIGS) and host‐induced gene silencing (HIGS) strategies are used for functional studies of AM fungi. Here, we identify the three HOG1 (High Osmolarity Glycerol 1)‐MAPK cascade genes RiSte11, RiPbs2 and RiHog1 from Rhizophagus irregularis. The expression levels of the three HOG1‐MAPK genes are significantly increased in mycorrhizal roots of the plant Astragalus sinicus under severe drought stress. RiHog1 protein was predominantly localized in the nucleus of yeast in response to 1 M sorbitol treatment, and RiPbs2 interacts with RiSte11 or RiHog1 directly by pull‐down assay. Importantly, VIGS or HIGS of RiSte11, RiPbs2 or RiHog1 hampers arbuscule development and decreases relative water content in plants during AM symbiosis. Moreover, silencing of HOG1‐MAPK cascade genes led to the decreased expression of drought‐resistant genes (RiAQPs, RiTPSs, RiNTH1 and Ri14‐3‐3) in the AM fungal symbiont in response to drought stress. Taken together, this study demonstrates that VIGS or HIGS of AM fungal HOG1‐MAPK cascade inhibits arbuscule development and expression of AM fungal drought‐resistant genes under drought stress.