bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between self‐stigma and self‐compassion in patients with schizophrenia: A longitudinal study from hospital admission to first follow‐up after discharge
Authors: Toshi Keita , Nakanishi Miharu , Sakai Mai , Yoshii Hatsumi 
Published: January 2025

AbstractAimSelf‐stigma is a major factor preventing the recovery of individuals with schizophrenia. Psychosocial interventions can reduce self‐stigma, and mental health nurses may play a crucial role in leading them, but little is known about the modifiable factors that should be targeted. We aimed to investigate the association between self‐stigma and self‐compassion in patients with schizophrenia from admission to the first follow‐up after discharge.MethodsTwenty‐three patients with schizophrenia were recruited from an acute psychiatric ward in a private psychiatric hospital in Japan. Participants filled out the Japanese versions of the Internalized Stigma of Mental Illness (ISMI) scale, the Self‐Compassion Scale (SCS), and the Positive and Negative Syndrome Scale (PANSS) at the following three time points: 1 month after admission, discharge, and first follow‐up after discharge at outpatient care. We used a linear mixed model to examine the association between self‐stigma, self‐compassion, and the symptoms. In the first model, we used self‐stigma as a dependent variable and included time of assessment and positive and negative symptoms as independent variables. In the second model, we added self‐compassion to the independent variables.ResultsSelf‐stigma did not change over time. Regarding the linear mixed model, the first model showed that participants with more positive symptoms tended to report worse self‐stigma (p = .052). The second model showed a significant association between increasing self‐stigma and higher over‐identification (p = .001).ConclusionsOur results suggest that interventions focusing on over‐identification can reduce self‐stigma. Nurse‐led intervention programs with a focus on over‐identification should be further developed for effectiveness.
Psychological and Social Factors Associated With Reporting Post‐COVID Symptoms Among German Healthcare Workers: A Cross‐Sectional Study
Authors: Schick Valentin , Lieb Marietta , Borho Andrea , Morawa Eva , Geiser Franziska , Beschoner Petra , Jerg‐Bretzke Lucia , Albus Christian , Steudte‐Schmiedgen Susann , Baranowski Andreas M. , Mogwitz Sabine , Erim Yesim 
Published: January 2025

ABSTRACTBackgroundHealth care workers (HCW) with post‐COVID condition (PCC) are frequently reported to suffer from mental health impairment. Given HCW above‐average risk for mental health, research is necessary and risk factors need to be assessed.AimTo compare mental health and health of German HCW with and without PCC and to identify associated psychological and social factors.DesignCross‐sectional study.MethodOverall, 2816 German HCW participated (332 reported PCC). Measures were post‐COVID condition symptom sum score (PCSS), symptoms of depression (Patient Health Questionnaire‐2), anxiety (Generalised Anxiety Disorder‐2) and post‐traumatic stress disorder (PTSD) symptoms (Impact of Event Scale‐6), work–family conflict (Work–Family Conflict Scale), social support (ENRICHD Social Support Inventory), sense of coherence (Sense Of Coherence‐3 Scale) and working conditions. Group differences of HCW with and without PCC were investigated. Multiple linear regression analysis was performed for HCW with PCC. PCSS was the dependent variable. Independent variables were a.m. measures and age, gender, occupational group and migration background.ResultsHCW with PCC exhibited higher values, with medium effect sizes, for symptoms of depression, anxiety and PTSD. Small effect sizes were observed for work–family conflict, social support, sense of coherence and working conditions. Higher PCSS scores were associated with higher depression, anxiety, PTSD and work–family conflict levels, lower social support and sense of coherence and migration background. Being a physician was associated with lower PCSS.ConclusionLower mental health, social factors and resources may play a role in reporting severe post‐COVID symptoms. Further research is necessary to investigate these interactions using the biopsychosocial theory.Implication for the ProfessionThis study can help to understand PCC in HCW to design adjusted treatments and protect HCW from PCC and minimise their risk of PCC.Reporting MethodThis study complies with the Journal article reporting standards for quantitative research in psychology: The APA Publications and Communications Board task force report (Data S1).Public ContributionCaregivers are the sample group.
Association of Burnout and Intention‐To‐Leave the Job With Objective Nursing Workload and Nursing Working Environment: A Cross‐Sectional Study Among Intensive Care Nurses
Authors: Bruyneel Arnaud , Dauvergne Jérôme E. , Bouckaert Nicolas , Caillet Anaelle , Sermeus Walter , Poiroux Laurent , Van den Heede Koen 
Published: January 2025

ABSTRACTAimThe objectives of this study were to determine the prevalence of burnout risk and intention‐to‐leave among intensive care unit (ICU) nurses and analyse the association of these with workload and work environment.DesignA cross‐sectional survey of nurses working in ICUs was conducted in France between 15 January 2024 and 15 April 2024 alongside a longitudinal assessment of workload during the same period.MethodsICU nurse workload was assessed using the Nursing Activities Score (NAS). The risk of burnout was assessed using the Maslach Burnout Inventory scale and intention‐to‐leave the hospital was assessed with a binary question. A total of 1271 nurses working in 61 intensive care units completed the questionnaire and 14,134 NAS per patient and 1885 NAS per nurse were included in the study.ResultsThe median overall of burnout by hospital site was 64.7% [P25: 53.3–P75: 72.7] for the broad definition and a median of 20.7% [13.3–27.3] of ICU nurses reported an intent‐to‐leave their job. The median overall NAS score per nurse was 135.9% [121.4–156.9] and the prevalence of NAS scores exceeding 100% per nurse was 73.9% [62.8–80.3]. A significant association was found between nurses working in an ICU with a better work environment and all dimensions of burnout as well as the intention‐to‐leave the job. A prevalence in the hospital site of NAS scores exceeding 100% per nurse below the median was associated with a lower burnout (OR = 0.69, 95% CI: 0.50–0.88 for broad definition) and intention‐to‐leave the job (OR = 0.68, 95% CI: 0.50–0.92).ConclusionThis study found significant associations between burnout and the intention to leave the job for nurses in ICUs, mainly due to a better work environment and, to a lesser extent, a lower workload for nurses.Implications for the Profession and/or Patient CareIn an era of nurse shortages and absenteeism, it is crucial for institutions to retain their nursing staff. Our results should encourage hospital managers to take action to improve the ICU work environment and keep ICU workloads manageable to decrease burnout and the intention‐to‐leave the job among ICU nurses.Reporting MethodThis article follows the STROBE guidelines for the reporting of cross‐sectional studies.Patient or Public ContributionNo patient or public contribution.
Hysteroscopy combined with laparoscopy in the diagnosis and treatment of omentum majus incarceration secondary to uterine perforation: A case report and literature review
Authors: Li Xiaolin , Hu Jiandong , Li Jing , Tao Zhonge , Qu Quanxin , Li Fenge 
Published: January 2025

AbstractCervical dilatation, uterine evacuation, and curettage (D&E&C) are common gynecological procedures for abortion, yet they carry risks of complications such as uterine perforation and intra‐abdominal organ incarceration. Here, we report a rare case of a breastfeeding patient who had an embedded abdominal greater omentum in the anterior wall of the uterus and into the uterine cavity during D&E&C. We used combined hysteroscopic and laparoscopic treatment for this case and successfully removed the embedded greater omentum. Our experience underscores the importance of vigilant intraoperative monitoring and prompt management to prevent serious complications like infection and bowel injury. In conclusion, hysteroscopic and laparoscopic combination treatment can be a preferred approach to avoid serious adverse outcomes for uterus perforation patients who developed omentum majus incarceration.
Environmental Variation Influences Genome Evolution in Hispaniolan Trunk Anoles (Anolis distichus)
Authors: Myers Tanner C. , de Mello Pietro L. H. , Hime Paul M. , Glor Richard E. 
Published: January 2025

ABSTRACTEnvironmental variation often drives evolutionary processes like population differentiation, local adaptation and speciation. We used genome‐scale data to investigate the contribution of environmental variation to evolution of the North Caribbean bark anole (Anolis distichus), a widespread common lizard that exhibits impressive phenotypic variation across varying habitats on the island of Hispaniola. We obtained new double‐digest restriction‐associated DNA sequence data (ddRADseq) from nearly 200 individuals and used 53 GIS data layers representing a range of environmental variables. We first asked how environmental variation has contributed to genome‐wide differentiation across Hispaniola. We found that Hispaniola's three major mountain ranges contribute to deep genome‐wide divergence and patterns of migration, that some deeply genomically divergent populations occupy significantly different environments, and that environmental variation is broadly capable of explaining more range‐wide genomic differentiation than geographic distance alone. We then asked whether specific loci exhibit evidence of local adaptation to environmental variation using genotype‐environment association (GEA) methods. We initially identified hundreds of loci broadly distributed across the genome that are significantly correlated with one or more environmental variables, but ultimately found that fewer than 100 of these candidate loci are shared across different GEA methods applied to our entire dataset, and that only 10 candidate loci are shared by independent analyses of two regional subsets of our dataset, suggesting parallel evolution is infrequent. Our study shows that abiotic environmental variation has played a critical role in explaining the evolution and diversity of a widespread and phenotypically diverse Caribbean anole species.
Consensus outcomes between health professionals and parents for oral corticosteroids in treating preschool wheeze: a multi-national survey and nominal group technique study
Authors: Lee Bohee , Turner Stephen W , Hine Jasmine , McMurray Ann , Roland Damian , Borland Meredith Louise , Csonka Peter , Grigg Jonathan , Guilbert Theresa W , Jartti Tuomas , Oommen Abraham , Lewis Steff , Cunningham Steve 
Published: January 2025

ObjectiveTo obtain priority consensus for outcome measures of oral corticosteroid treatment of preschool wheeze that represent stakeholder groups.Design(1) A systematic review to identify a set of outcome measures; (2) an international survey for healthcare professionals (HCPs) and a nominal group meeting with parents; (3) a final consensus nominal group meeting with key HCPs (trial investigators and paediatric emergency medicine clinicians) and the same parent group.Main outcome measuresConsensus priority of treatment outcome measures, outcome minimal clinically important differences (MCIDs) and level of concerns about adverse effects.ResultsThrough an iterative process engaging HCPs and parents, the final consensus on a primary outcome was Wheezing Severity Score (WSS). Secondary outcomes prioritised as a revisit to general practice/emergency department, rehospitalisation, length of hospital stay (LOS), time back to normal, doses of short-acting beta-agonists and additional steroid course. Compared with placebo, clinicians considered the median MCID change in WSS at 4 and 12 hours as 40% (IQR 29–51%) and 50% (37–63%) and 5 hours (4–6 hours) for LOS, and 2 days (2–3 days) for a time back to normal. Parents identified MCIDs which were frequently longer than physiologically observed impacts in trials. Concerns about multiple steroid doses were most prevalent.ConclusionsStakeholders prioritised change in WSS as the most favourable outcome measure. Our study demonstrated the potential of parent/patient engagement in co-creating patient research outcomes. Incorporating this result in the design of future clinical research will provide a more holistic assessment of the impact of treatment while ensuring relevant primary research outcomes.
Intimate partner violence help-seeking norms: scale reliability and cross-sectional multilevel associations with intimate partner violence among youth in Nairobi, Kenya
Authors: Williams Anaise , Wood Shannon N. , Thiongo Mary , Gichangi Peter , Devoto Bianca , Bevilacqua Kristin G. , Wamue-Ngare G , Decker Michele R. 
Published: January 2025

ObjectivesIntimate partner violence (IPV) threatens women’s health and safety. Support services can mitigate the impact, yet few survivors seek services in part due to social norms that discourage use. Little agreement exists on how to measure norms and attitudes related to IPV help-seeking. The objectives were to (1) refine an IPV Help-Seeking Attitudes Scale and examine its psychometric properties, (2) explore differences in attitudes between young men and young women, and (3) examine associations of past 6-month IPV among young women with the scale at the individual level (individual attitudes) and the by-gender community-aggregated averages (community norms) among youth in Nairobi, Kenya.DesignThis cross-sectional, secondary analysis used data from a phone-based survey with a cohort of young men and young women recruited via respondent-driven sampling from April to May 2021. Cross-sectional exploratory factor analysis assessed underlying latent constructs. Multilevel mixed-effects models assessed associations with IPV experience for young women.Setting and participantsA youth cohort of 586 men and 591 women aged 15–24 years in Nairobi, Kenya.Primary outcome measurePast 6-month physical and/or sexual IPV among young women.ResultsThe IPV Help-Seeking Attitudes Scale had acceptable internal reliability (Cronbach’s alpha >0.60). IPV prevalence was 17.5%, among whom 21.7% had sought any help for the past 6-month IPV. A one-unit increase in the community aggregate IPV Help-Seeking Attitudes Scale among young women was associated with reduced odds of IPV (aOR: 0.17, 95% CI: 0.03–0.98). However, the individual-level attitudes scale was not associated with IPV nor was the men’s community aggregate scale.ConclusionsThe IPV Help-Seeking Attitudes Scale had adequate psychometric properties. The results suggest that young women living in a community where the norm among women enables IPV response may have a reduced risk of IPV. Community norms change to better enable IPV response among young people may help reduce IPV and increase help-seeking.
Is the time to task failure during severe intensity exercise associated with muscle, blood, and respiratory changes?
Authors: Zagatto Alessandro M. , de Poli Rodrigo A.B. , Malta Elvis S. , Fleitas-Paniagua Pablo R. , Diefenthaeler Fernando , Murias Juan M. , Castro Alex 
Published: January 2025

Purpose: The study aimed to verify the physiological and metabolic parameters associated with the time to task failure (TTF) during cycling exercise performed within the severe-intensity domain. Methods: Forty-five healthy and physically active males participated in two independent experiments. In experiment 1, after a graded exercise test, participants underwent constant work rate cycling efforts (CWR) at 115% of peak power output to assess neuromuscular function (Potentiated twitch) pre- and post-exercise. Experiment 2 was similarl to experiment 1, but with physiological (respiratory parameters, energetic pathway contribution) and metabolic parameters in the blood (gasometry and blood lactate responses) and vastus lateralis muscle tissue (target metabolomic analysis, glycogen content, muscle pH and buffering capacity in vitro) measured instead of neuromuscular function. Results: Experiment 1 evidenced a significant decrease in muscle force with instauration of peripheral fatigability indices and no change in central fatigue indices. Severe-intensity domain exercise in Experiment 2 was accompanied by changes in physiological and metabolic parameters and in blood and muscle parameters. However, the TTF was associated with oxidative contribution (r=0.811, p<0.001), as well as anaerobic capacity (r=0.554, p=0.027), muscle buffering capacity (r=0.792, p=0.035), phosphagen energy contribution (r=0.583, p=0.017), and carnitine changes (r=0.855, p=0.016), but no correlated with electromyographic response, blood acid-base balance, and muscular glycogen content and pH. Conclusion: TTF during CWR exercise within the severe-intensity domain is likely explained by a combination of interacting mechanisms, with oxidative and phosphagen contributions, and muscle buffering capacity suggested as the main peripherals limiting factors to exercise within this exercise intensity domain.
Abstract 045: First‐Line Mechanical Thrombectomy Device in Intracranial Atherosclerotic Large Vessel Occlusion
Authors: Mierzwa A. T. , Al Kasab S. , Almallouhi E. , Jumaa M. ,   RESCUE‐ICAS Registry
Published: January 2025

Introduction
First‐line mechanical thrombectomy devices are associated with heterogeneous functional and safety outcomes in large vessel ischemic stroke. Successful recanalization rates are influenced by associated technical difficulties of navigating torturous vessels and interactions with recalcitrant thrombi of atherosclerotic lesions. As such, studies are required to evaluate these devices to determine the optimal initial thrombectomy approach in patients with these lesions.

Method
This is an analysis of the RESCUE‐ICAS international prospective observational registry which included patients with residual stenosis (50‐99% reperfusion) following successful mechanical thrombectomy. Patients were dichotomized into those receiving first‐line aspiration catheter or stentriever devices. Primary and secondary efficacy outcomes were defined as excellent functional outcomes (modified Rankin Scale 0‐2) and procedure times, respectively. Primary safety outcomes were defined symptomatic intracranial hemorrhage (sICH) rates. Multivariate analysis was performed on the primary outcome.

Results
There were four‐hundred‐twenty‐six patients included in this analysis with 218 and 208 patients receiving first‐line aspiration catheter and stentriever devices, respectively. Patients were generally older (median 68 years old) Caucasian (59%) males (61%). Patients in the aspiration catheter cohort were more likely to have dyslipidemia (55% vs 45% p = 0.04) and prior stroke (28% vs 19% p = 0.03) compared to the stentriever cohort; no other significant differences were noted. At 90‐days, there were equivalent rates of excellent functional outcomes in the aspiration and stentriever cohorts (35.4% vs 31.4% p = 0.48) and redemonstrated following multivariate analysis (OR 0.90 95% CI 0.59 ‐ 1.37; p = 0.62). Yet, aspiration catheters were noted to have shorter procedure times (45 mins vs 62 mins p < 0.001). Additionally, there was a trend towards lower sICH rates in the aspiration cohort (5% vs 9.6% p =0.07) compared to the stentriever cohort.

Conclusion
There were equivalent primary functional outcomes in patients with atherosclerotic large vessel occlusions treated with either aspiration catheter or stentriever devices yet, procedure times favored aspiration catheters. There was a trend towards lower symptomatic ICH rates with first‐line aspiration catheters. Further randomized studies are required to further evaluate procedural benefits and risks.
Abstract 098: Endovascular Treatment of Symptomatic Bilateral Carotid Artery Occlusions
Authors: Fakih R. , Tolba H. , Detmer K. , Merriman W. , Elkolaly S. , Gillani S. , Qureshi A. I. 
Published: January 2025

Introduction
The annual incidence of acute ischemic strokes or transient ischemic attacks due to chronic carotid occlusion (CCO) is estimated at 5‐10%. While initial trials did not show a clear benefit for surgical treatment of symptomatic CCO, emerging data suggests that endovascular treatment (EVT) may offer significant advantages over best medical management (BMM) in selected cases. However, the use of EVT for bilateral symptomatic CCO has not been previously investigated.

Method
We present the case of a 67‐year‐old male with a history of oropharyngeal carcinoma, treated with extensive neck radiation, leading to bilateral common carotid artery occlusions. The patient, initially presenting for elective gastric endoscopy, experienced hypotension during anesthesia induction and subsequently became comatose. Imaging revealed complete occlusion of the bilateral common carotid arteries and the right vertebral artery, with CT perfusion showing extensive global hypoperfusion correlating with severe EEG attenuation. Due to the failure of medical management, EVT was deemed necessary.

Results
A femoral approach was utilized for endovascular access to each common carotid artery. The procedure involved the use of a guide catheter, microwires for crossing occlusions, and multiple angioplasties with various balloon sizes to create a passage through the occlusions. An embolic protection device was employed to prevent iatrogenic distal embolization. Rheolytic thrombectomy aided in recanalization, followed by the placement of several stents in a telescopic fashion to achieve vessel patency. Intravascular ultrasound (IVUS) was performed pre‐ and post‐recanalization to evaluate vessel integrity. The procedure resulted in the complete recanalization of both carotid arteries, with subsequent resolution of perfusion abnormalities and normalization of electroencephalographic patterns. The patient returned to his neurological baseline within days post‐procedure.

Conclusion
This case demonstrates the safe and effective use of EVT for the treatment of bilateral chronic carotid artery occlusions. It highlights the potential of EVT as a promising therapeutic option in managing CCO, particularly in cases where medical management fails.