bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling of magnetic vestibular stimulation experienced during high-field clinical MRI
Authors: Arán-Tapia Ismael , Pérez-Muñuzuri Vicente , Muñuzuri Alberto P. , Soto-Varela Andrés , Otero-Millan Jorge , Roberts Dale C. , Ward Bryan K. 
Published: January 2025

Abstract

Background
High-field magnetic resonance imaging (MRI) is a powerful diagnostic tool but can induce unintended physiological effects, such as nystagmus and dizziness, potentially compromising the comfort and safety of individuals undergoing imaging. These effects likely result from the Lorentz force, which arises from the interaction between the MRI's static magnetic field and electrical currents in the inner ear. Yet, the Lorentz force hypothesis fails to explain observed eye movement patterns in healthy adults fully. This study explores these effects and tests whether the Lorentz force hypothesis adequately explains magnetic vestibular stimulation.

Methods
We developed a mathematical model integrating computational fluid dynamics, fluid-structure interaction solvers, and magnetohydrodynamic equations to simulate the biomechanical response of the cristae ampullares. Using high-resolution micro-CT data of the human membranous labyrinth, we ensured anatomical accuracy. Experimental validation involved measuring horizontal, vertical, and torsional slow-phase eye movements in healthy subjects exposed to varying magnetic field intensities and head positions.

Results
Our model accurately replicates observed nystagmus patterns, predicting slow-phase eye velocities that match experimental data. Results indicate that Lorentz force-induced stimulation of individual cupulae explains variability in eye movements across different magnetic field intensities and head orientations.

Conclusions
This study empirically supports the Lorentz force hypothesis as a valid explanation for magnetic vestibular stimulation, offering new insights into the effects of high-field MRI on the vestibular system. These findings provide a foundation for future research and improved clinical practices.
Ephrin A1 functions as a ligand of EGFR to promote EMT and metastasis in gastric cancer
Authors: Li Shuang , Sun Meng , Cui Yun , Guo Dongyang , Yang Feng , Sun Qiang , Ding Yinuo , Li Mengjie , Liu Yiman , Ou Guangshuo , Zhuo Wei , Zhou Tianhua 
Published: January 2025

Abstract
Distant metastasis is the major cause of gastric cancer mortality, and epidermal growth factor receptor (EGFR) activation plays critical roles in gastric cancer dissemination. However, EGFR targeting therapies in gastric cancer show only marginal effects, and the molecular mechanisms of oncogenic EGFR signaling remain poorly defined. Here, we report Ephrin A1 as a novel ligand of EGFR in gastric cancer. Ephrin A1 facilitates colonization and metastasis of gastric cancer cells in vitro and in vivo via inducing epithelial-mesenchymal transition (EMT). Ephrin A1 directly interacts with EGFR and induces EGFR dimerization, phosphorylation and activation of downstream signaling. Ephrin A1-induced EMT can be rescued by EGFR signaling inhibitors or knockout of EGFR, but not depletion of its classical receptor EphA2. Moreover, Ephrin A1 protein level correlates with EGFR phosphorylation levels in gastric cancer patients. Collectively, our work uncovers Ephrin A1 as a functional ligand of EGFR and highlights the potential role of the Ephrin A1/EGFR/EMT regulatory axis in cancer metastasis.
Optimal liquidation with conditions on minimum price
Authors: Popier Alexandre , Ali Sezer Devin , Aksu Mervan 
Published: January 2025

The classical optimal trading problem is the closure of a position in an asset over a time interval; the trader maximizes the expected revenues under the constraint that the position be closed by terminal time. Since the asset price is stochastic, the liquidation constraint is too restrictive; the trader may want to relax it or slow down/stop trading depending on price behavior. We consider two additional parameters that serve these purposes within the Almgren-Chriss framework: a binary valued process that prescribes when trading takes place and a set that prescribes when full liquidation is required. The permanent price impact parameter enters the problem as the negative part of the terminal cost. A terminal cost that can take negative values implies that the BSDE associated with the value function of the control problem can explode backward in time and that existence results on solutions of BSDE with singular terminal values are not directly applicable. When liquidation costs are quadratic, the problem is convex and, under a general filtration, the minimal supersolution of the BSDE gives the value function and the optimal control. For the non-quadratic case, we assume a stochastic Markovian volatility model. These give PDE/PDE-system representations for the value functions.
Patient-Reported Outcome Measures in Patients with Diabetes Mellitus:
Findings from the Diabetes Landeck Cohort
Authors: Haslwanter Veronika , Hallson Lára R. , Rochau Ursula , Siebert Uwe , Schönherr Hans Robert , Oberaigner Wilhelm 
Published: January 2025

Abstract
Introduction Maintaining and optimizing quality of life (QoL) is a central
issue and one of the most important goals in therapy for patients with chronic
diseases, such as diabetes mellitus (DM). Despite its importance, there is
little data on the QoL of patients with DM in Austria. The objective of this
study was to extend an established population-based cohort, the Diabetes-Landeck
cohort, by including patient-reported outcomes.
Methods We performed a survey on quality of life (QoL) and treatment
satisfaction in patients from the Diabetes-Landeck cohort using the EQ-5D-5L,
the problem areas in diabetes survey (PAID), and the diabetes treatment
satisfaction questionnaire (DTSQ). Mean sum scores were calculated and compared
between patient characteristic subgroups.
Results In total 58 patients were recruited, with a mean age of 63 years
and a mean hemoglobin A1c (HbA1c) of 7.1%. The mean sum score of EQ-5D-5L was 92
(SD=10.6), and that of DTSQ and PAID were 32.2 (SD=6.6) and 10.8 (SD=11.6),
respectively. Patients with obesity (body mass index ≥ 30 kg/m2)
showed a statistically significant decreased mean sum score of EQ-5D-5L and a
statistically significant increased mean sum score of DTSQ. Patients with HbA1c
≥7.5% showed a statistically significant decreased mean sum score of DTSQ.
Conclusion We observed patient-reported outcomes significantly associated
with obesity and HbA1c, which could be used for targeted patient monitoring.
Limited by small sample size and questions in generalizability, we strongly
suggest the rollout of a larger study.
Impact of Body Mass Index on the Initial Phase of a Minimally Invasive Aortic Valve Program
Authors: Ewais Elias , Bauer Nadja , Schlömicher Markus , Bechtel Matthias , Moustafine Vadim , Hamdani Nazha , Strauch Justus T. , Haldenwang Peter Lukas 
Published: January 2025

Abstract
Background In obese patients, minimally invasive surgical aortic valve replacement (MIS-AVR) presents challenges, and the risk of patient–prosthesis mismatch (PPM) is elevated. This retrospective single-center study evaluates the impact of body mass index (BMI) on the outcome of an initial MIS-AVR program.
Material and Methods A total of 307 patients underwent MIS-AVR between January 2013 and December 2015, the initial phase of our MIS-AVR program. They were divided into normal/overweight (BMI <30 kg/m2) versus obese patients (BMI ≥30 kg/m2). Primary endpoints included 30-day and 2-year mortality and stroke. Secondary endpoints comprised type 3 bleeding, PPM, paravalvular leakage, wound healing disorders (WHDs), and pacemaker rates.
Results In all 191 patients exhibited a BMI <30 kg/m2, while 116 patients had a BMI ≥30 kg/m2. The BMI groups did not differ in baseline characteristics, excepting a higher peripheral arterial disease incidence among obese patients (15.7% vs. 26.7%; p = 0.01). Aortic clamp time (75 ± 29 min vs. 87 ± 37 min; p = 0.001), cardiopulmonary bypass (104 ± 36 min vs. 124 ± 56 min; p = 0.0002), and ventilation times (26 ± 6 h vs. 44 ± 8 h; p = 0.03) were longer in obese patients. They demonstrated a higher risk for bleeding (2.6% vs. 9.5%; p = 0.008) but lower pacemaker rates (9% vs. 3%; p = 0.02). PPM, paravalvular leakage, and WHD exhibited no group differences. No BMI-related differences revealed in 30-day mortality (4.7% vs. 3.4%) and stroke rates (2% vs. 2.6%), as well as 2-year mortality (12.6% vs. 11.2%) and stroke rates (2.1% vs. 2.6%).
Conclusion In the initial phase of an MIS-AVR program, the 30-day mortality may be elevated. Despite longer operative times and an increased risk for bleeding in obese patients, no influence of BMI on postoperative morbidity, mortality, or stroke rates was observed.
Exosomes and exosomal miRNAs mediate the beneficial effects of
exercise in ischemic stroke
Authors: Tan Xuefeng , Ding Zhimin , Shi Lizhen , Wu Ruonan 
Published: January 2025

AbstractIschemic stroke is an acute cerebrovascular disease that is one of the leading
causes of death and neurological disorders worldwide. Exosomes are a novel class
of intercellular signaling regulators containing cell-specific proteins, lipids,
and nucleic acids that transmit messages between cells and tissues. MicroRNAs
are regulatory non-coding ribonucleic acids that are usually present in exosomes
as signaling molecules. Studies have shown that exosomes and exosomal microRNAs
can improve the prognosis of ischemic stroke by inhibiting the inflammatory
response, reducing apoptosis, improving the imbalance of oxidative and
antioxidant systems, and regulating cellular autophagy, among other processes.
Previous studies have shown that exercise training can exert neuroprotective
effects on ischemic stroke by promoting the release of exosomes and regulating
the expression of exosomal microRNAs, which in turn regulate multiple signaling
pathways. Exosomes and exosomal microRNAs may be key targets for exercise to
promote cerebrovascular health. Therefore, the study of exercise-mediated
exosomes and their microRNAs may provide new perspectives for exploring the
mechanism of exercise intervention in the prevention and treatment of ischemic
stroke.
Feasibility and Challenges of Pyeloureteral Magnetic Anastomosis Device in Domestic Pigs: A Stepwise Approach with Extended Observation
Authors: Kubiak Rainer , Hornok Zita , Csukas Domokos , Ferencz Andrea , Cserni Tamas 
Published: January 2025

Abstract
Objective The pyeloureteral anastomosis remains the most challenging part of pyeloplasty. A purpose-built anastomotic device could simplify this step and potentially improve outcomes. The concept of a pyeloureteral magnetic anastomosis device (PUMA) was proven in minipigs, but only in short term. Our aim was to test the PUMA in domestic pigs and achieve a prolonged follow-up period.
Methods Five female domestic pigs underwent laparoscopy and ligation of the left ureter. Four weeks later, laparoscopic implantation of the PUMA was planned. Removal of the device and a retrograde contrast study were scheduled after another 4 weeks. The experiment was terminated when the animals could no longer be properly cared for due to their weight.
Results Due to unexpected smaller ureteric diameters, a modified PUMA could only be successfully inserted in pig number 3 (49 kg). Four weeks later, the device was found to be dislocated, but the anastomosis remained patent. After modifying the study protocol, the PUMA was successfully implanted in pigs number 4 (96 kg) and 5 (68 kg) 8 weeks after ureteric ligation. Pig 4 developed malignant hyperthermia and died. In pig 5, the magnets were removed 4 weeks later. After an additional 8 weeks, the animal reached 135 kg and was terminated. The anastomosis remained patent and preserved its diameter.
Conclusion Despite limitations, our study successfully demonstrated that the PUMA can achieve a patent ureteric anastomosis in domestic pigs. This suggests a potential for minimally invasive ureteric anastomosis in clinical settings. Further research is needed to optimize the technique and validate its effectiveness in humans.
Sustained success in endoscopic performance demonstrated by the Irish National Endoscopy Quality Improvement Programme
Authors: Keating Eoin , Slattery Eoin , Hartery Karen , Doherty Glen , Canavan Conor , Leyden Jan 
Published: January 2025

AbstractThe National Gastrointestinal Endoscopy Quality Improvement (NEQI) Programme captures over 94% of endoscopic activity in the Republic of Ireland (ROI), accounting for > 120,000 colonoscopies per annum. The aim of this study was to assess temporal changes in colonoscopy Key Quality Indicators (KQIs) at a national level over a 5-year period among low-, intermediate-, and high-volume endoscopists.A retrospective analysis of all NEQI colonoscopy episodes occurring between 2016 and 2022, collating colonoscopy KQIs (cecal intubation rate [CIR], comfort score [CS], polyp detection rate [PDR] and sedation use). Endoscopists with 5 consecutive years of activity were defined as low, intermediate, or high activity according to annual procedural volumes.Over 658,000 colonoscopies were completed by 1240 endoscopists. Workload is disproportionate, with 36% of endoscopists completing 66% of national colonoscopy volume. Low-, intermediate-, and high-activity endoscopists all demonstrated sustained improvements in KQI targets over the study period. Comparing experts (≥ 300 colonoscopies/year) vs non-experts, KQI plateaus were demonstrated for PDR at < 150 colonoscopies per year (34.2% vs 29.6%, P = 0.002), CS at < 200 procedures per year (97.5% vs 94.9%, P < 0.001), and CIR at < 250 colonoscopies per year (94.5% vs 93.4%, P = 0.048).This study represents the first published endoscopist-level NEQI data demonstrating ongoing KQI improvements for endoscopists at all activity levels. Sustaining this improvement and continuing to capture national endoscopic performance will remain a core role of the Irish NEQI program. Workforce imbalances and minimum annual volumes continue to represent challenges for national endoscopy programs.
Endoscopic transpapillary gallbladder stenting vs percutaneous cholecystostomy for managing acute cholecystitis: Nationwide propensity score study
Authors: Pan Chun-wei , Ramai Daryl , Beran Azizullah , Wang Yichen , Huang Yuting , Morris John 
Published: January 2025

AbstractCholecystectomy is the standard treatment for acute cholecystitis, but it may not be suitable for all patients. For those who cannot undergo surgery, a percutaneous cholecystostomy tube (PCT) and ERCP-guided transpapillary gallbladder drainage are viable options. We aimed to perform a nationwide study to assess 30-day readmission rates, adverse events (AEs), and mortality rates in these two cohorts.We conducted a nationwide cohort study using data from the Nationwide Readmissions Database (NRD) from 2016 to 2019. We identified patients with acute cholecystitis during the index admission who underwent either PCT or ERCP-guided gallbladder drainage. Propensity score matching along with multivariable regression was used to compare cohorts.During the study period, 3,592 patients (average age 63.0 years) underwent endoscopic drainage, whereas 80,372 patients (average 70.8 years) underwent Interventional Radiology drainage. Utilizing multivariate Cox regression analysis, compared with ERCP, PCT had a higher risk for 30-day readmission (adjusted hazard ratio [aHR] 1.47; 95% confidence interval [CI] 1.27 to 1.71; P < 0.001). The PCT group had a significantly higher rate of readmission for acute cholecystitis compared with the ERCP group (2.72% vs 0.86%; P < 0.005). Cox proportional hazard ratio showed a 3.41-fold increased risk (95% CI 1.99 to 5.84) for readmission in the PCT group. ERCP was consistently associated with lower rates of post-procedural AEs compared with PCT including acute hypoxemic respiratory failure (P < 0.001), acute renal failure (P < 0.001), shock (P < 0.001), and need for blood transfusions (P < 0.001).Our nationwide analysis revealed that ERCP-guided gallbladder drainage should be the preferred approach for managing acute cholecystitis when unfit for surgery.
A Comparative Analysis of Cell Proliferation and Wound Closure in Cultured Gingival Epithelial Cells Using Plasma Rich in Growth Factors and Platelet-Rich Plasma Containing Leukocytes
Authors: Watanabe Yuri , Shimada Katsumitsu , Doi Yousuke , Higuchi Takuyoshi , Kato Yoshiya , Li Xianqi , Kurihara Yuji , Murakami Satoshi 
Published: January 2025

Abstract
Objectives Plasma rich in growth factors (PRGF) is presumed to be able to stimulate the regeneration of skin and periodontal tissue. This effect can be attributed to the fact that PRGF contains fewer leukocyte-derived interleukins in comparison to platelet-rich plasma (PRP). However, a comparison of the effects of PRGF and PRP on gingival epithelial cells has not been conducted yet. Therefore, our objective was to clarify and compare the effects of PRGF and PRP on gingival epithelial cell proliferation, wound healing, and gene expression.
Materials and Methods PRGF and PRP were obtained from three donors. A complete medium containing bovine pituitary extract (BPE) and growth factors was used as a positive control (PC), while a medium without BPE was used as a negative control (NC). We evaluated the presence of platelets and leukocytes, as well as the number of leukocytes, in PRP and PRGF using the cell block method and a cell counting chamber. We assessed gingival epithelial cell proliferation with WST-1 and wound healing by using cell-free culture inserts. To examine the mRNA expression of tumor necrosis factor-α (TNF-α), which is related to cell growth inhibition, and integrin β4, which contributes to cell adhesion, we used quantitative reverse transcription polymerase chain reactions (RT-PCRs) under PRGF and PRP samples in vitro. The nonparametric data were analyzed using the Kruskal–Wallis test.
Results Large quantities of platelets were observed in both PRGF and PRP. The leukocyte concentration in PRGF was generally lower than that in PRP. Our report indicated that cell proliferation was significantly higher in PRGF than in PRP on day 1 and 2. We found that there was no significant difference in the wound closure rate between PRGF and PRP in comparison to their respective control groups. The quantitative RT-PCR revealed insignificant differences in mRNA expression as TNF-α and integrin β4 between PRGF and PRP in comparison to the each of their respective control groups.
Conclusion Our research indicated that PRGF can promote the proliferation of gingival epithelium more than PRP, contributing to the healing of periodontal tissue. TNF-α and integrin β4 mRNA expression may not be significantly involved in wound closure within the gingival epithelium under the influence of PRGF and PRP.
Analgesic Effect of Intermittent Multiple IPACK Block Combined with ACB in Patients with Flexion Contracture Knee Arthritis Undergoing Total Knee Arthroplasty
Authors: Ren Yuqi , Hou Zhouhui , Zhang Yue , Li Yue , Liu Huanqiu 
Published: January 2025

AbstractWe aimed to compare the analgesic effects of intermittent multiple infiltrations between the popliteal artery and capsule of the posterior knee (IPACK) combined with adductor canal block (ACB) and intermittent ACB alone in patients with flexion contracture knee arthritis undergoing total knee arthroplasty (TKA). Forty-six patients who underwent elective unilateral TKA were divided into two groups (n = 23 each): intermittent multiple IPACK combined with ACB (group IA) and intermittent multiple ACB (group A). ACB was performed with 20 mL of 0.375% ropivacaine in each group and IPACK with 20 mL of 0.25% ropivacaine in group IA. Intermittent multiple nerve blocks were used for postoperative analgesia (IPACK block combined with ACB in group IA and ACB in group A between 7:30 and 8:30 a.m. on postoperative day 1 [POD1] and postoperative day 2 [POD2]). Primary outcomes assessed were pain at rest, motion-evoked pain (MEP), and range of motion (ROM) on POD1 and POD2. Secondary outcomes included opioid consumption, first ambulation time, ambulation distance, and postoperative complications. We observed that compared with group A, MEP decreased, ROM became wider, ambulation distance was longer, and opioid consumption decreased in group IA. Other outcomes were either similar between the groups or showed clinically insignificant differences. We conclude that multiple intermittent IPACK therapy combined with ACB provides superior analgesia than multiple intermittent ACB therapy alone in patients with flexion contracture knee arthritis undergoing TKA.
Glycemic Control of Children and Adolescents with Type 1 Diabetes in the United Arab Emirates: A Narrative Review.
Authors: Adhami Sara , James Steven , Paterson Megan , Deeb Asma , Craft Judy 
Published: January 2025

Abstract
Background Diabetes is the fastest-growing chronic disease in the world with increased morbidity and mortality associated with a diagnosis at a young age. The landscape of glycemic control of children and adolescents in the United Arab Emirates, a dynamic and fast evolving country in the Middle East, is unknown, potentially limiting decisions around patient care, health system planning, and efforts around advocacy.
Aim This article determines the reported glycemic control of this vulnerable population, and factors influencing blood glucose management.
Methods A quantitative epidemiological narrative review was conducted using PubMed, CINAHL, and Cochrane databases, searched from 2012 to 2023. English studies involving the study population were reviewed and appraised.
Results Overall, 16 studies were included, mainly heralding from Abu Dhabi and involving Emirati nationals. Reported mean hemoglobin A1c (HbA1c) ranged from 7.9 to 9.6% (63–81 mmol/mol) and diabetes-related technology use was high. Themes identified were diabetes and technology, education, psychology, and Ramadan.
Conclusion Glycemic control was suboptimal, with mean HbA1c being hyperglycemic across included studies, despite a high use of diabetes-related technology. Unless change is made, children and adolescents and young adults with type 1 diabetes will likely experience unnecessary morbidity and mortality.
Preparation and mechanical-electrical characterization of new complex-phase conductive concrete
Authors: Feng Shicheng , Zhang Xiaohui , Xu Zhilei , Dong Keliang , Zheng Jinfeng , Zhang Runlong , Zhou Zhaolin , Wang Xuan 
Published: January 2025

The transmission line tower foundation is the key to determining the safe and stable operation of transmission lines under high current impact, and conductive concrete plays a vital role in the safe and stable operation of transmission lines. However, the mechanical and electrical properties of conductive concrete have a competitive relationship, and balancing these properties simultaneously is a current research problem. This paper proposes a new method for the preparation of novel multiphase electrically conductive concrete fiber composites and elucidates the mechanism of its electrical resistivity and compressive and flexural properties. The effects of concrete, graphite and stainless steel fibers as conductive phase materials on the changing law of physical properties of conductive concrete were compared, and the optimal ratio of the content of conductive phase materials was explored. A numerical calculation model of multi-field coupling of a new type of conductive concrete under high current impact was established. The results demonstrate that when the graphite content is 20% and the stainless steel fiber content is 2.75% ± 0.1%, the mechanical and electrical properties ratio is the best. The resistivity was reduced by 54%, the compressive strength was increased by 47.4%, and the flexural strength was increased by 151.4% compared to graphite conductive concrete. The new conductive concrete has promising frontiers of steady-state electricity and transient heat under 20 kA high current impingement, with its current density value dropping to 3280A/m3 and the maximum module temperature dropping to 2270 K. Relevant research provides a theoretical reference for guaranteeing the safe operation of power systems.