bluuebunny/crossref_metadata_2025_split huggingface dataset:
RET/PTC rearrangement in papillary thyroid carcinoma arising in malignant struma ovarii with abdominal wall metastasis and cervical thyroid gland: A case report and review of the literature
Authors: Kabootari Maryam , Tirtashi Reza Habibi , Zadeh-Vakili Azita , Zarkesh Maryam , Samadanifard Hossein , Azizi Fereidoun , Amouzegar Atieh 
Published: January 2023

Abstract
Background: Struma ovarii refers to rare mature cystic teratomas containing at least 50% of thyroid tissue, and malignant transformation is known to be even rarer. The synchronous development of malignant struma ovarii and cervical thyroid carcinoma are also scarce and poorly understood due to limited data about molecular features. Here, we present the first report of RET/PTC 1 rearrangement in synchronous metastatic malignant struma ovarii to the abdominal wall and cervical thyroid cancer.
Case presentation: We described a 47-year-old multigravida woman with bilateral adnexal and lower abdominal wall masses detected during the evaluation of abnormal uterine bleeding. The patient underwent a hysterectomy, bilateral salpingo-oophorectomy, and surgical removal of abdominal wall mass. Then, the pathological evaluation revealed papillary thyroid carcinoma (PTC) within struma ovarii and metastatic PTC in the abdominal wall fibro adipose tissue. Further, cervical thyroid gland physical examination and ultrasound illustrated a nodule within the left lobe. Subsequently, a total thyroidectomy was performed, and a histological examination revealed PTC. Furthermore, all affected tissue, i.e., struma ovarii, abdominal wall metastasis, and cervical thyroid gland tested for BRAF and RAS mutations and RET/PTC 1 rearrangement. RET/PTC 1 rearrangement was identified among all three different sites. Finally, after six years of follow-up, the patient had no evidence of recurrence or distant metastasis.
Conclusions: In light of these findings, malignant struma ovarii might yield a clue to cervical thyroid carcinoma, and the molecular analysis could provide valuable information for understanding the underlying mechanism, tumor clinicopathological behaviors, and prognosis.
Scale-dependent release of Borrelia burgdorferi sensu lato infected Ixodes ricinus larvae from vertebrates
Authors: Takumi Katsuhisa , Holding Maya Louise , Fabri Nannet D. , Sprong Hein , Heylen Dieter 
Published: January 2023

AbstractBackground:The multi-host tickIxodes ricinusis the principal vector of zoonotic diseases in Europe. Quantifying the contribution of each host species in the tick’s pathogen transmission cycles is imperative in spatio-temporal pathogen exposure assessments, but remains challenging in the absence of techniques identifying the previous host on which (infectious) host-searching ticks have fed. Based on European literature data, we here investigate the capacity of vertebrate species to infect naïve larvae with particularBorreliagenospecies belonging to the multi-host pathogen complexBorrelia burgdorferisensu lato (the causative agent of Lyme Borreliosis in humans).Methods:We calculated the number of infected larvae generated by an infectious host. This measure (‘realized release’) was subsequently used to investigate intrinsic host infectiousness (through adjustment for tick exposure), lifetime release, and spatial dilution. Host abundances from naturally occurring vertebrate communities were subsequently used to estimate their local contributions to the population of infectious host-searching nymphs.Results:Thirty-one vertebrates were identified as amplifying hosts; vertebrate species that successfully generate larvae infected with aBorreliagenospecies. In 1-ha forest plots, per genospecies one vertebrate species released a disproportional amount of infected larvae. Several bird species show (high) infectiousness for non-avian genospecies:B. lusitaniae,B. burgdorferisensu stricto andB. afzelii. At population level, due to their smaller home ranges in combination with higher densities and tick exposures, several mammal species locally intensely contributed to mammalian genospecies (B. afzelii,B. burgdorferis.s. andB. bavariensis). In contrasts, due to their larger home ranges and lower tick exposure, the birds’ local contributions were more restricted – this despite their higher intrinsic infectiousness (reservoir competence). Given their seemingly lower specificity in amplification, birds are the main driver in the maintenance of pathogen diversity across macro-geographic scales.Conclusions:Ecological factors that affect the infection pressures and reservoir competence are still poorly understood in one of the best-studied tick-borne zoonoses (B. burgdorferis.l.). To anticipate current rapidly changing abiotic environmental conditions – inevitably affecting tick exposures and zoonotic risks - we advocate the generation of field-experimental data on host reservoir competence based on larval infections.
Cementless total hip arthroplasty for treatment of acetabular protrusion secondary to rheumatoid arthritis
Authors: liu peng , Qiao yongjie , Lou jinpeng , Cao guoding , Chang yanfeng , Zhen ping , zhang haoqiang , 周 胜虎 
Published: January 2023

Abstract
Background: To explore the surgical technique and clinical outcomes of cementless total hip arthroplasty (THA) combined with impacted bone grafting in treating moderate and severe acetabular protrusion with rheumatoid arthritis (RA).
Methods: From January 2010 to October 2020, 45 patients (56 hips) with RA secondary to acetabular invagination were treated with biological prosthesis THA combined with autologous bone grafting in our hospital, including 17 males (22 hips) and 28 females (34 hips). According to Sotello-Garza and Charnley classification criterion, there were 40 cases（49 hips）of typeⅡ(protrusio acetabuli 6-15 mm), and 5 cases（7 hips）of type Ⅲ (protrusio acetabuli ＞15 mm). At the postoperative follow-up, the ROM of the hip joint, the VAS score, and the Harris score were evaluated. The healing of the bone graft, the restoration of the hip rotation center, and the prosthesis loosening were assessed by plain anteroposterior radiographs.
Results: The average operation time was 95.53 ± 22.45 min, and the mean blood loss was 156.16 ± 69.25 mL. There were no neurovascular complications during the operation. The mean follow-up duration was 5.20 ± 1.20 years. The horizontal distance of the hip rotation center was increased from preoperative 10.40 ± 2.50 mm to postoperative 24.03 ± 1.77 mm, and the vertical distance was increased from preoperative 72.36 ± 3.10 mm to postoperative 92.48±5.31 mm. The range of flexion motion of the hip joint increased from 39.48 ± 8.36° preoperatively to 103.07 ± 7.64° postoperatively, and the range of abduction motion increased from 10.86 ± 4.34° preoperatively to 36.75 ± 3.99° postoperatively. At the last follow-up, the Harris score increased from 37.84 ± 4.74 to 89.55 ± 4.05. All the patients could move independently without assistance.
Conclusions: Cementless THA combined with impacted grafting granule bone of the autogenous femoral head and biological acetabular cup can reconstruct the acetabulum, restore the rotation center of the hip joint, and achieve good medium-term outcomes in the treatment of moderate and severe acetabular protrusion secondary to RA.
Information Extraction System for Cargo Invoices
Authors: Tan QiuXing Michelle , Cao Qi , Seow Chee Kiat , Yau Peter Chunyu 
Published: January 2023

Abstract
Rapid growth in the digitization of documents, such as cargo invoices or receipts, has alleviated the demand for methods to process information accurately and efficiently. However, it has become impractical for humans to extract the data due to the size of the corpus. Furthermore, extracting the information manually can be labor-intensive and time-consuming as employees need to go through multiple digitized invoices and extract the critical information. The digital documents, such as digital cargo invoices contain various components such as tables, key-value pairs and figures. Existing optical character recognition (OCR) method are able to recognize texts. But it is challenging for them to extract the key-value pairs in unformatted digital cargo invoices. Hence, creating a smart information extraction system that can extract key-value pairs would be beneficial, as it would help organizations achieve workflow efficiency, resource utilization and eliminate costly errors. In this paper, a pipeline of the information extraction system is proposed with deep learning approaches for classifying key-value pairs first, followed by linking the key-value pairs. Two merging rules and two pairing rules are developed in the proposed pipeline. Various experiments have been conducted to illustrate the performance of the system.
Drug Design, Molecular Docking and Dynamics Studies on the Interaction of Voxelotor, L- Glutamine and Hydroxy Urea with Human Carbonmonoxy Hemoglobin S
Authors: Jibrin Anne , Uzairu Adamu , Shallangwa Gideon Adamu , Abechi Stephen Eyije , Umar Abdullahi Bello 
Published: January 2023

Abstract
Sickel cell disease (SCD) is a defect in hemoglobin structure that leads to deficiency in oxygen transfer in the body. Voxelotor, L- Glutamine and Hydroxyurea are three out of the four drugs approved by the FDA to treat SCD, yet the disease is incurable. The medical community are searching for new drug and new drug target that can cure or inhibit the product of this disease. In this research, we used molecular docking, molecular dynamics (MD) simulation and ADMET studies to analyze the interactions of these drugs. MD potential of the three drugs into the active site of hemoglobin S was investigated. Voxelotor has the highest score, with a binding energy of -21.66 kcalmol-1. Out of the Eight new drug designed based on the backbone of Voxelotor, it was found out that Vox8 has the best binding energy of -24.73 kcalmol-1, followed by Vox7 with binding energy of -22.30 kcalmol-1 and Vox4 with -21.81 kcalmol-1 respectively. The docking results were validated with the aid of MD simulations, the results revealed that the complex of the ligand and the receptor protein is stable at 300K. For the prediction of blood-brain barrier penetration, the SwissADMET web based service was able to predict the BBB profile for the designed drugs, Lipinski’s rule was obeyed, bioavailability Score were good which led to the understanding of the biological activities of the compounds.
KIF5A inhibition ferroptosis in Parkinson's disease
Authors: Wu Peipei , Wu Chunxiao , Han Jiajun , Huang Zifeng , Hao Xiaoqian , Zhao Lijun , Chen Dongfeng , Zhu Meiling 
Published: January 2023

Abstract
Parkinson's disease (PD) is a highly prevalent neurodegenerative disorder associated with abnormal brain iron metabolism. Ferroptosis is a newly discovered form of iron-dependent cell death. In recent years, many studies have identified ferroptosis as an important pathogenic mechanism of PD. Nevertheless, the underlying mechanisms remain unclear. A 6-hydroxydopamine (6-OHDA) stimulated the PD rat model and the PD cell model were used in this research. The experimental results showed that the level of kinesin 1 heavy chain (KIF5A) decreases, and the level of ferroptosis increases after 6-OHDA stimulation. A PD cell model is consistent with these results. The overexpression of KIF5A in SH-SY5Y cells significantly reduces intracellular lipid peroxidation, Fe2+ accumulation, and ferroptosis. In contrast, knockdown of KIF5A exacerbated lipid peroxidation and Fe2+ accumulation, and cellular ferroptosis was more severe. Therefore, this study provides new views and potential for studying treatment targets of PD by demonstrating that KIF5A protects cells from ferroptosis in a PD model.
Modeling and mechanistic approach for acid red 88 dye removal by hydrothermally synthesized magnetic chitosan-grafted with side chain salicylaldehyde
Authors: Hapiz Ahmad , Arni Laili Azmiati , Khadiran Tumirah , ALOthman Zeid A. , Wilson Lee D. , Jawad ALI H. 
Published: January 2023

Abstract
This research used the hydrothermal process to cross-link biopolymer magnetic chitosan (CS/Fe3O4) with an aromatic aldehyde (salicylaldehyde, SA) for the adsorption of acidic azo dye (AR88) from an aqueous environment. Analyses of VSM, pHpzc, CHNS, XRD, SEM-EDX, FTIR, and BET were used to determine the properties of CS-SL/Fe3O4 material. Using the Box-Behnken design (BBD), the effects of A: CS-SL/Fe3O4 dose range from 0.02–0.1 g, B: [AR88] concentration (10–50 mg/L), C: pH (4–10), and D: duration (10–90 min) on the adsorption performance of CS-SL/Fe3O4 toward AR88 dye were systematically investigated. In this research, the Freundlich isotherm and pseudo-second-order kinetic models were applicable to describe the adsorption rate of AR888 molecules. The maximum adsorption capacity (qmax) of the hydrothermally cross-linked CS-SL/Fe3O4 for AR88 dye was 137.3 mg/g. Multiple mechanisms, including electrostatic attraction, π-π stacking, n-π interaction, and H-bonding, are responsible for AR88 adsorption by CS-SL/Fe3O4. This study demonstrates that hydrothermal preparation of cross-linked CS-SL/Fe3O4 offers an effective and promising adsorbent for removing acidic dyes from polluted water.
Novel association of SMARCA4 deletion with Dermatofibrosarcoma protuberans: Novel insights and expansion of the molecular change of this tumour
Authors: Deng Huiyan , Jia Ying , Jia Keqi , Fan Xiaojie , Liu Yueping 
Published: January 2023

Abstract
Dermatofibrosarcoma protuberans (DFSP) is a rare indolent soft tissue sarcoma of the skin that accounts for less than 1 % of all soft tissue sarcomas. Clinically, it is a slow-growing, localised, low-grade, malignant fibrosarcoma. Here, we report the case of a 40-year-old woman diagnosed with DFSP harbouring a deletion in the SMARCA4 gene. The tumour was completely removed after surgery and the 1-year follow-up, no recurrence or additional malignancy was observed. Our review of the existing literature suggests that DFSP with a SMARCA4 gene deletion have not been reported to date. This case furthers our understanding on the molecular biology of DFSP for soft tissue sarcomas, which will therefore help clinicians to more accurately assess the prognoses of patients.
Polyoxometalate/carbon black modified glassy carbon electrode for the detection of dopamine
Authors: Liu Xiong , Zhong Cailing , Ji Jun , Yang Wei , Tian Zhengfang , Chen Yichang , Tian Qifeng 
Published: January 2023

Abstract
Dopamine (DA) is a crucial neurotransmitter in the central nervous system (CNS) of human and multicellular animal brains. In this paper, we report for the first time the synthesis of C/PWA composites by doping phosphotungstic acid (PWA) on carbon black nanoparticles by impregnation method. The synthesized materials were characterized and corroborated using high-resolution scanning electron microscopy, X-ray diffraction spectroscopy (XRD) and Fourier transform infrared spectroscopy. The synthesized C/PWA composite modified glassy carbon (GC) electrodes were used as selective electrocatalysts for dopamine (DA) oxidation process. The electrochemical redox behavior of DA was studied with cyclic voltammetry (CV). Under optimized conditions, DA was detected by differential pulse voltammetry (DPV) and the calibration plot showed linearity (R2 = 0.9988) over the range of DA concentrations of 10 µM-600 µM with a detection line of 0.1 µM. The sensor's capability to detect DA in commercial DA injections in real time has been successfully demonstrated.
Pharmacokinetics of Apixaban in Patients Undergoing Pancreaticoduodenectomy (PAP-UP)
Authors: Zheng Richard , Lam Edwin , Altshuler Peter , Crutcher Madison , Lavu Harish , Yeo Charles J. , Stickle Douglas , Leiby Benjamin , Kraft Walter K. 
Published: January 2023

Abstract

Background: The impact of pancreaticoduodenectomy (PD) on absorption of drugs in the duodenum remains largely unknown. We aim to characterize the pharmacokinetics of apixaban in patients who have previously underwent PD.
Methods: A single 10 mg dose of apixaban was administered to four volunteers who underwent PD at least 6 months prior. The maximum plasma apixaban concentration (Cmax) and area under the plasma concentration time-curve (AUC0-24, AUC0-inf) were compared against healthy historical control subjects (N=12). Geometric mean ratios (GMR) with 90% confidence interval (CI) were calculated for determination of comparative bioequivalence.
Results: In PD patients AUC0-24 and AUC0-inf were 1861 and 2080 ng•hr/mL, respectively. The GMRs of AUC0-24 and AUC0-inf between study subjects and healthy controls were 1.27 (90% CI 0.88-1.83) and 1.18 (90% CI 0.82-1.72). The mean Cmax of apixaban was 201 ng/mL (SD 15.6) occurring at a median Tmax of 3.25 hours (range 2.5-4 hours). The GMR of Cmax between study subjects and healthy controls was 1.12 (90% CI 0.77-1.63).
Conclusions: The pharmacokinetic characteristics of apixaban in subjects who have undergone PD are not significantly different from those of healthy controls. No changes in their dosing regimen are recommended.
ClinicalTrials.gov Identifier: NCT04191928
Experimental determination of Rayleigh scattering cross sections at 408 nm
Authors: LIU YANGZHUORAN , HERNÁNDEZ MARIA DOLORES ANDRÉS , GEORGE MIDHUN , BURROWS JOHN PHILIP 
Published: January 2023

Abstract
Accurate knowledge of the Rayleigh scattering cross sections, σRayl, of atmospheric gases as a function of wavelength is required for radiate transfer calculations and also for the calibration of optical systems e.g. high finesse optical cavities. The cavity ring-down spectroscopy (CRDS) is a highly accurate absolute method which enables experimentally determined σRayl to be compared with σRayl n-values calculated for atmospheric gases using knowledge of the refractive index. In this study, CRDS has been applied to measure light extinction and to retrieve highly accurate σRayl of nitrogen, N2, oxygen, O2, argon, Ar, carbon monoxide CO, carbon dioxide, CO2, nitrous oxide, N2O, methane, CH4 molecules and synthetic air (SA) at 408 nm. Experiments using step pressure changes and pressure ramps in three optical cavities were used to retrieve σRayl. These agree on average within 0.6% with the calculated σRayl n-values for CO2, N2O and CH4 and within 2.4%, 1.2%, 2.2%, 1.5%, and 4.1% for N2, O2, SA, Ar and CO respectively. For N2O and CH4, these results confirm experimentally the inaccuracies resulting from extrapolating the refractive index and King correction factors from other wavelength regions to the region around 408 nm, reported elsewhere.
Mortality trend of four major non-communicable diseases in China, 2009-2020
Authors: wu tiantian , wang lianke , hu bo , yao zihui , wang yu , zhang peijia , sun changqing 
Published: January 2023

Abstract
Background
Non-communicable diseases (NCD) have become the leading cause of death in the world at present. Among them, the most important are cardiovascular diseases (CVD), cancer, chronic respiratory diseases and diabetes. This study aimed to analyze the time trends of mortality rates caused by the four major non-communicable diseases (NCD4) in China between 2009 and 2020, and to provide the evidence basis for policy implementation, information system, and health resource management of chronic NCD in China.
Methods
Data on resident death was collected from the National Mortality Surveillance data set and used to analyze the crude mortality rates, standardized mortality rates and changing trends of NCD4 among different genders, urban and rural areas, and geographical regions in China from 2009 to 2020. The Joinpoint Regression Models were fitted by the weighted least squares method. The average annual percent change (AAPC) and its 95% confidence interval (CI) were calculated for the entire time period.
Results
From 2009 to 2020, the standardized mortality from four major NCD combined in China decreased from 534.51 to 395.84%, with the AAPC value at -2.8% (95% CI [-3.7% to -1.8%]). The standardized mortality from CVD, cancer, and chronic respiratory diseases decreased, but the standardized mortality of diabetes increased, with AAPC values at -2.2%, -1.8%, -8.0% and 1.9% respectively.
Conclusions
From 2009 to 2020, the mortality rate of chronic NCD is on the decline, but chronic NCD have become the leading cause of death of residents. Close attention needs to be paid on NCD which affecting the health of the labor force population in China. The prevention and treatment of diabetes, male and west region NCD should be enhanced.
Lamina structure in fine-grained sedimentary rocks: scale, mineral assemblage and well log characterization
Authors: Lai Jin , Zhang Mei , Zhao Fei , Pang Xiaojiao , Zhao Yidi , Li Hongbing , Liu Bingchang , Wang Guiwen 
Published: January 2023

Abstract
A novel method is proposed to characterize the multi-scale lamina structure in fine-grained sedimentary rocks using geophysical well logs. The low limit of individual lamina detection using geophysical well logs is improved to 2.5 mm through image log derived slab image and button conductivity curves. Lamina structure in terms of composition and texture of individual lamina as well as lamina assemblages are determined from core and thin section images. Fine-grained sedimentary rocks are divided into massive, layered and laminated according to core-scale lamina observation. Thin section observation reveals that the mineral composition of individual lamina includes carbonate, silt, clay mineral, tuffaceous lamina and organic matter lamina in the micrometer-scales. The lamina couplets (silt-organic, silt-clay, tuff-organic and carbonate-silt) or triplets (silt-clay-organic) can be classified according to the mineral assemblage. Static and dynamic image logs with 5 mm vertical resolution have low ability to capture the lamina assemblage. Therefore the slab images and button conductivity curves are generated from image logs to facilitate the recognition of laminae. The color patterns (dark-yellow-light-bright) and conductivity values (width of curves) of button conductivity curves can reflect the variations in composition and texture of individual lamina. Core and thin section are calibrated with slab images as well as button conductivity curves to build a method to recognize multi-scale lamina structure. This novel and multidisciplinary approach provides a powerful method for continuously identifying lamina structure with a 2.5 mm vertical resolution using well logs, and have theorical and practical implications for lamina investigation in fine-grained sedimentary rocks.
Spiked solutions for fractional Schrödinger systems with Sobolev critical exponent
Authors: Chen Wenjing , Huang Xiaomeng 
Published: January 2023

Abstract
Note: Please see pdf for full abstract with equations.
In this article, we study the following fractional critical Schrödinger system
(−Δ)sui = μiu3i+ βuiΣj≠i u2j+ λiui in Ω,
ui = 0 on RN \ Ω, i = 1, 2, · · · , m,
where 0 < s < 1, μi > 0, coupling constant β satisfies either −∞ < β ≤ ¯ β ( ¯ β > 0 small) or β → −∞,0 < λi < λs1(Ω), where λs1(Ω) is the first eigenvalue of (−Δ)s on Ω, with Ω is a smooth bounded domain in RN with N = 4s. Under some geometric assumptions on Ω, we construct solutions which concentrate and blow up at different points as λ1, · · · , λm → 0.
2020 Mathematics Subject Classification: Primary 35R11, 35J60; Secondly 47G20.