bluuebunny/crossref_metadata_2025_split huggingface dataset:
EGFR Mutation-positive Lung Cancer in Real-world Treatment Outcomes: A Multicenter Study from Thailand
Authors: Sukauichai Sitthi , Maneenil Kulthida , Supavavej Archara , Paul Vinai , Benjawongsathien Duangnapa , Chantharakhit Chaichana , Neesanun Sunee , Chayangsu Chawalit , Bowornkitiwong Thissawan , Sukaraphat Napawan 
Published: December 2022

Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have been the standard of care as first-line (1L) therapy for patients with advanced EGFR mutated lung cancer since 2009. In Thailand, however, it was not fully introduced to all health care funds until 2020. The purpose of this study was to determine the overall survival (OS) and treatment pattern in the period before EGFR-TKI became universally available to all patients.
Methods: This was a retrospective study conducted at 10 medical centers in Thailand. Patients harboring the common mutation (exon 19 deletion or exon 21 L858R) diagnosed during January 2013 and December 2019 were enrolled.
Results: This study included 284 patients with a median follow-up time of 19.8 months and a death rate of 80.3% (228/284). Clinical characteristics included median age 62.5 years, female 65.5%, never-smoking 74.3%, stage 3B/4/recurrence 2.1/93.3/4.6%, exon 19/exon 21- 60.9/38.7%. Treatment patterns to EGFR-TKI included not receiving (NR) (9.5%), first-line (1L) (56.0%), switch maintenance (MN) (3.5%), second-line (2L) (21.8%) and third-line (3L) or more (9.2%). Median OS of patient receiving EGFR-TKI as NR, 1L+MN, 2L and 3L or more was 11.10 (95%CI: 8.21 to14.00), 19.08 (95%CI: 15.76 to 22.41), 23.06 (95%CI: 15.91 to 30.21) and 32.46 (95%CI: 21.61 to 43.30) months (p=0.006), respectively. Factors contributing to poor prognosis in the multivariate model included poor ECOG-PS (HR 3.17, 95%CI: 1.96-5.13), not receiving EGFR-TKI (HR 3.83, 95%CI, 1.94-7.56) and receiving EGFR-TKI 1L (HR 2.30, 95%CI: 1.40-3.79)
Conclusion: OS of patients with EGFR mutation positive lung cancer treated with EGFR-TKIs in Thailand was comparable to clinical studies. EGFR-TKI treatment should be provided to patients as early as possible, but TKI remained beneficial at later points in the treatment timeline.
IMPLEMENTASI PROGRAM BANTUAN LANGSUNG TUNAI (BLT) BAGI MASYARAKAT MISKIN DI KABUPATEN MAJENE
Authors: Kusmin Achmad Fauzi , Taufiq Muhammad Syihabuddin , Rahmatullah  
Published: December 2022

Objek penelitian ini adalah implementasi program Bantuan Langsung Tunai (BLT) di Kabupaten Majene. Penelitian ini bertujuan untuk mengetahui ketepatan implementasi program bantuan langsung tunai di kabupaten Majene berdasarkan berbagai aspek menurut teori implementasi kebijakan Van Meter dan Van Horn. Metode yang digunakan dalam penelitian ini adalah metode penelitian deskriptif dengan pendekatan kualitatif untuk menganalisis implementasi program bantuan langsung tunai di kabupaten Majene. Penulis mengumpulkan berbagai data mengenai program BLT yang dilakukan melalui kajian pustaka dan wawancara dengan masyarakat dan aparatur desa setempat. Informan dalam penelitian ini adalah 5 orang dari desa Buttu Baruga Kecamatan Banggae Timur dan di Desa Tinambung Kecamatan Pamboang. Penetapan sampel dilakukan dengan menggunakan metode unit analisis. Hasil penelitian menunjukkan bahwa implementasi program bantuan langsung tunai bagi masyarakat miskin di Kabupaten Majene telah terimplementasi dengan cukup baik. Hal ini dapat dilihat dari berbagai aspek pengukur, diantaranya adalah aspek standar dan sasaran kebijakan, sumberdaya, karakteristik badan pelaksana, dan disposisi implementor. Setiap aspek memiliki berbagai indikator yang menentukan terpenuhi atau tidaknya suatu aspek.
STRATEGI INCUMBENT DALAM PEMENANGAN PEMILIHAN LEGILSLATIF
Authors: Nasiruddin Nurfadilah , Mausili Dwi Rianisa , Nuraliah Dewi 
Published: December 2022

Tujuan Penelitian ini menganalisis strategi incumbent dalam Pemenangan Pemilihan Legislatif. Metode Penelitian menggunakan metode kualitatif, data dikumpulkan dari hasil observasi secara langsung, wawancara secara langsung dan mendalam. Tipe penelitian ini yakni deskriptif analisis. Teknik analisis data kualitatif dilakukan secara interaktif dan berlangsung secara terus menerus sampai tuntas. Aktivitas dalam analisis data yaitu pengumpulan data (data collection), reduksi data (data reduction), penyajian data (data display), dan pengecekan keabsahan data serta penarikan kesimpulan (data conclusion drawing/verification).
Hasil dari penelitian ini yakni komunikasi yang intesn dengan masyarakat, bukan saja pada saat akan pemilihan tetapi jauh sebelum pemilihan akan dimulai, selain komunikasi incumbent juga memiliki pendekatan kekeluargaan yang kesemuanya dapat dibagai dengan tiga pendekatan. Pertama, menggalang loyalitas pemilih sehingga calon legislatif memiliki pemilih yang tetap pada setiap pemilihan. Kedua, menjalin komunikas yang harmonis dengan organisasi masyarakat (kelompok populis tertentu )untuk memberikan dukungan dan bantuan. Ketiga, bagi incumbent yang masih duduk di parlemen, memperkuat kebijakan yang berorientasi pada masyarakat.
Penelitian ini, memiliki keterbatasan yakni hanya membatasi strategi yang dilakukan incumbent pada satu partai sehingga kedepannya peneliti menyerankan untuk meneliti berbagai strategi dari partai lain sehingga memberikan pemahaman dan pengetahuan yang lebih luas lagi.
Державне регулювання операцій з імпорту в умовах воєнного стану
Authors: ФОМІНА Олена , РОМАШКО Ольга , ШАПОВАЛОВА Алла 
Published: December 2022

Вступ. Значна частка в зовнішньоторго­вельному обороті України належить імпорту товарів, на який негативно вплинула війна в Україні. Верховна Рада України постійно вносить зміни у законодавство, що вимагає від суб’єктів господа­рювання оперативно приймати ефективні управ­лінські рішення.
Проблема. Об’єктом дослідження є операції з імпорту товарів, обсяг яких з введенням воєнного стану в Україні скоротився.
Мета статті – аналіз змін законодавства щодо імпорту товарів в умовах воєнного стану, валютних обмежень за операціями імпорту та їхнього впливу на збільшення попиту на імпортні товари з боку суб’єктів господарювання.
Методи. Методика дослідження передбачає аналіз даних щодо вартісного обсягу імпорту за місяці воєнної агресії рф, а також тимчасових змін в законодавстві.
Результати. Розглянуто загальну структуру імпорту України за перші шість місяців агресії рф. Проаналізовано дані Національного інституту стратегічних досліджень щодо імпорту порівняно з аналогічним періодом 2021 р. Фактором змен­шення обсягів імпорту є введення воєнного стану в Україні та заборона будь-якого імпорту з рф. Для прийняття ефективних рішень щодо здійснення зовнішньоекономічної діяльності постійно вносилися зміни в нормативно-правові акти. Зміни в законо­давстві дали можливість полегшити процедури декларування окремих товарів під час перетину митного кордону, спростити документальне оформлення товарів і звільнити від оподатку­вання товари для здійснення заходів із забезпе­чення національної безпеки та оборони.
Висновки. Війна в Україні негативно вплинула на розвиток економіки та міжнародну торгівлю. Відбулася зміна фокуса імпорту товарів, оскільки передусім завозилися товари критичного імпорту. Верховна Рада України постійно вносила зміни в нормативно-правові акти, що дало змогу суб’єктам господарювання імпортувати товар і розрахо­вуватися з нерезидентами.
Prevalencia de síndrome metabólico en adolescentes escolarizados del Departamento Central en el año 2021
Authors: Gaona Nelly , Sanabria Marta Cristina , Piris Angela , Dong Chin Suh , Pereira Patricia , Cuevas Maria Teresa 
Published: December 2022

Introducción: El Síndrome Metabólico (SM) es una entidad clínica que se manifiesta por obesidad central, dislipidemia, hiperglicemia y/o hipertensión arterial y se relaciona con el desarrollo de Diabetes Mellitus tipo 2 y enfermedades cardiovasculares.
Objetivo: Determinar la prevalencia del SM en adolescentes escolarizados del Departamento Central en el 2021 y evaluar los factores de riesgo relacionados.
Materiales y Métodos: Estudio descriptivo con componente analítico. Ingresaron 279 adolescentes de 10 a 16 años de 6 escuelas elegidas aleatoriamente. Se realizó una encuesta sobre estilos de vida, prácticas alimentarias, antecedentes familiares y perinatales. Se realizó medición de peso, talla, circunferencia de cintura (CC), glicemia, perfil lipídico y presión arterial. Para el diagnóstico de SM se utilizó los criterios de Cook. Aprobado por el Comité de Ética del IICS y del Hospital de Clínicas. Para el análisis se utilizaron tablas de frecuencias, mediana y Prueba del Chi cuadrado para razón de prevalencias (RP) con nivel de significancia p < 0,05.
Resultados: Mediana de edad 13 años en general y 11,5 años en SM, 53 % fueron hombres. La prevalencia de sobrepeso fue del 22,9 % y de obesidad 26,16 %. La hiperglicemia fue del 0,01 %, hipertrigliceridemia 16 %, HDL bajo 37,9 %, Prehipertensión arterial 11% y CC > p90 36%. La prevalencia de SM fue del 10,7 %. La CC >p90 con RP de 31,4 (7,6-128), y la hipertrigliceridemia con RP de 46,8(14,8-147,7), fueron los componentes preponderantes de SM. El peso elevado al nacer y no realizar actividad física, fueron identificados como factores de riesgo significativo.
Conclusiones: La prevalencia de SM fue 10,7%, se relacionó con mayor peso al nacimiento, obesidad y sedentarismo.
Deficiencias de cobre, hierro y zinc en niños menores de 5 años
Authors: Sanabria Gabriela , Estigarribia Gladys , Kennedy Cristel , Aguilar Gloria , Galeano Fernando , Sanabria Marta , Kawabata Aníbal , Vuyk Iris , Muñoz Sergio , Pizarro Fernando 
Published: December 2022

Introducción: La determinación de niveles séricos de micronutrientes de los niños menores de 5 años, es un requerimiento básico para establecer la prevalencia de deficiencias nutricionales de la población infantil y es una estrategia útil para incentivar a Salud Pública para que tome medidas en cuanto a aplicación y/o modificación de las Políticas Alimentarias Nacionales.
Objetivo: Determinar los niveles séricos de cobre, hierro y zinc en niños paraguayos menores de 5 años.
Materiales y Métodos: Estudio observacional, descriptivo y de corte transversal. Se procesaron las muestras de sangre de 1.441 niños menores de 5 años de edad que provenían de los Departamentos de Alto Paraná, Caaguazú, Central y de la capital de Paraguay. Se realizaron hemogramas y se determinaron las concentraciones séricas de albúmina, cobre, ferritina y zinc, de todas las muestras.
Resultados: Los niños tuvieron una edad promedio de 3 años y 3 meses, fueron 52,74% de sexo masculino y 47,26% de sexo femenino. La prevalencia de anemia fue de 45,25% y la prevalencia de hipoalbuminemia fue de 20,65%. Se detectaron deficiencias de cobre en 14,03%, de ferritina en 6,98% y de zinc en 43,62%, de los niños.
Conclusión: Los resultados de este estudio avalan la necesidad de ampliar la cobertura del Programa Alimentario Nutricional Integral (PANI), de plantearse si se deben ajustar las cantidades de minerales y vitaminas de la fórmula nutricional del Programa y de mejorar el seguimiento de los controles prenatales de las madres.
Studi Kinerja Rumah Sakit Berbasi Balance Scored (Studi Kualitatif di RSUD Kota Madiun di Lingkungan Manajemen)
Authors: Ridhosari Dewi , Wardani Ratna 
Published: December 2022

Background: Organizational performance is something produced by an organization in a certain period with reference to established standards. Management performance measurement aims at work efficiency using balanced score card (BSC), which is a performance measurement solution. BSC consists of two dimensions: financial and non-financial dimensions. The purpose of the study was to describe the measurement of the performance of the Madiun City general hospital using the Balance Scorecard method.Methods: Research design uses qualitative descriptive methods. The selection of informants was obtained from observations and interviews to employees of the Madiun Citygeneral hospital with 7 respondent. This study used purposive sampling techniques. Research instruments with observation sheets, interview guidelines and documentation studysheets.Results: The results of the study at the general hospital in Madiun City area showed that financial performance was considered good, the achievement of customer satisfaction levels in 2020 was quite good, the perspective of internal business processes could not be achieved at standard numbers due to the Covid-19 pandemic, the achievement of employee satisfaction levels in the good category even though there were 3 elements that were considered less good.Conclusions: The results of the research conducted are expected by the hospital should use performance assessment based on the concept of balance score card to implement and integrate the strategic planning of the hospital. Hospitals also need to improve employee capabilities by providing training to employees in turns, or organizing inhouse training to save costs. The perspective of benefit performance is that the poor must be served in Madiun City Hospital.
Yabancılaşmayı Bir Karakter Üzerinden Okumak: Peyami Safa’nın “Meral”i
Authors: HİSARCIKLILAR Emel 
Published: December 2022

Yabancılaşma kavramı, toplum içerisinde yaşayan ve diğer bireylerle iletişim halinde olan kişinin, inandığı değerlerin, sahip olduğu düşüncelerin, hayat algısının; çevresiyle uyuşmamasından doğan bir çatışma hali sonucunda yavaş yavaş değişmesi ve kendini bulunduğu ortama ait hissetmemesi durumudur. Çeşitli düşünürler ve sosyologlar tarafından tanımlanan bu kavram hakkında incelemeler yapan bir isim de Melvin Seeman’dır. O, yabancılaşmayı beş boyut eşliğinde incelemiştir. Bunlar güçsüzlük, anlamsızlık, kuralsızlık, soyutlanma ve kendine yabancılaşmadır. Güçsüzlük, bireyin zihnindeki düşünceleri gerçekleştirmek için harekete geçememesi; anlamsızlık, varlığına ve dünyaya değer ifade eden bir anlam yükleyememesi; kuralsızlık, zihninde tasarladığı hedeflere ancak kuralları çiğneyerek ulaşabileceğini düşünmesi; soyutlanma, içinde yaşadığı topluma ve onun değerlerine bir anlam yükleyememesi ve kendine yabancılaşma, geleceğe dönük beklentileri birer birer yok olduktan sonra, derin bir ümitsizlik ve yalnızlığa düşmesidir. Sanat alanında eserlere çeşitli şekillerde yansıyan yabancılaşma, Türk edebiyatında da kendine yer bulmuştur. Bu çalışmada Peyami Safa’nın “Yalnızız” adlı romanının kişilerinden biri olan Meral karakteri, eserde bu konuyu en belirgin şekilde yansıtan karakter olarak Seeman’ın yabancılaşma teorisine göre incelenecektir.
Meral karakteri bu doğrultuda incelendiğinde onun, kişisel özgürlük alanının sınırlandırıldığı endişesiyle bazı toplumsal kuralları ve değerleri çiğnediği, ahlaki olmayan durumlar içerisinde yer aldığı, ailesinin ve Samim’in tasvip etmediği arkadaşlıklar içinde bulunduğu görülmektedir. Samim’in ona yaptığı uyarılar ve ikisinin, hayat hakkındaki sohbetleri; kendisine karışılmasından, yaptıklarına müdahale edilmesinden hoşlanmayan Meral için bunaltıcı olmaktadır. Meral’i bunaltan etkenler; çevresindekiler tarafından hürriyetinin kısıtlanması yani iradesinin kontrol edilmek istenmesinin yanı sıra, yalnızlaşması hem de kalabalık içerisindeyken bile yalnız hissetmesidir. Meral’in, içine düştüğü kötü durumlar ve bu durumların, çevresindekiler tarafından tasvip edilmemesi ve özellikle de ağabeyi tarafından gördüğü baskı dolayısıyla kendisini değersiz, öz varlığını anlamsız hissettiği görülmektedir. Yaptıklarından dolayı zaman zaman vicdan azabı çekse de, kendi kendine yaptığı sorgulamalara cevap bulamayan Meral hayatını ve bu hayatı çekilmez hale getirdiğini düşündüğü kuralları anlamsız bulmaya başlamıştır. Karşısına çıkan zorluklarla mücadele etmek için gücünün kalmadığını düşünerek, sonunda öz varlığına dahi yabancılaşan Meral, kendisini sınırsız bir özgürlüğe kavuşturacağını düşündüğü kaçış düşüncesini gerçekleştiremeyince ölümü, kurtuluş için tek çare olarak görmüştür. İntiharı düşünmesine rağmen, romanın sonunda bir kaza sonucu yanarak ölen Meral’den geriye kalan not; onun yok oluşa sürüklenmesinin en önemli nedeninin hakikatte dünyadaki yalnızlığı olduğunu göstermektedir. İçine düştüğü yabancılaşma onu yalnızlığa, ümitsizliğe, kaçış ve ölüm düşüncesine doğru sürüklemiştir.
كتاب "خداينامه" بين التراثين الفارسي والعربي
Authors: ALBAKOUR Moustafa 
Published: December 2022

خداينامه أحد أهم الكتب الإيرانية القديمة في العصر الساساني، ويعدّ بمثابة التاريخ القومي للإيرانيين وسجلّ حماساتهم وأبطالهم وحروبهم، ودفتر آدابهم وحِكمهم وسُنَنهم. ترُجم خداينامه من اللغة الفارسية الفهلوية إلى العربية على يد عبدالله بن المقفّع (106-142هـ) وآخرين، وشكّلت ترجماته البنية الأساسية للتواريخ الإسلامية العربية والفارسية التي تناولت تاريخ بلاد فارس قبل الإسلام. وقد تناولنا في بحثنا هذا تاريخ تأليف هذا الكتاب ومصادر تأليفه، وترجماته إلى العربية، وفصّلنا في أهمّها وهي ترجمة ابن المقفّع، وتأثيرها في المصادر التي تناولت تاريخ بلاد فارس العربية والفارسية.
إن كتاب خداينامه، على الرغم من ضياع أصله وترجماته إلى العربية، شكّل حلقة مهمّة من حلقات التأثّر والتأثير بين الحضارتين الفارسية القديمة والعربية الإسلامية طوال قرون عدّة، وقد فتح المجال واسعاً أمام نهضة كبيرة في مجال التأليف والترجمة العربية والفارسية، وفي العقود الأخيرة أنجز المستشرقون الغربيون العديد من الدراسات المهمّة حول هذا الكتاب وترجماته وتأثيره، وقد تناولنا أهمّها في هذا البحث، وعرضنا وجهات النظر المتشابهة والمختلفة في هذا الباب.
Predicting Climate Change Related Extreme Natural Disasters Using Machine Learning in Zambia
Authors: Phiri David , Chembe Christopher 
Published: December 2022

One of the most important concerns affecting humanity today is climate change that has led to increased frequency of natural disasters that threaten social and economic stability to populations. Zambia’s vulnerability to the threat of disasters remains high because the country still lacks an effective Early Warning System (EWS). This study recognises the need to evaluate various Machine Learning (ML) algorithms, that have been successfully implemented in disaster prediction, in order to develop a model for Zambia. Six ML algorithms, namely; Logistic Regression (LR), Random Forest (RF), K-Nearest Neighbor (KNN), Gaussian Naive Bayes (GNB), Decision Tree (DT), and Support Vector Machine (SVM), have been compared from which the best performing is chosen. The historical climate data is obtained from the Zambia Meteorological Department (ZMD) while historical natural disasters data was obtained online because it is not locally available. The study results show that LR and SVM algorithms performed better than the others, both scoring 73.0% accuracy, respectively. LR is chosen to produce the final model because it has a shorter computational time compared to SVM. The model is then incorporated in a web service and android application for deployment. However, the high number of outliers, missing values and highly imbalanced classes affect the performance of the model. ML data cleaning and feature engineering techniques, such as Data Imputation and Oversampling Techniques, are applied but certain challenges still persist because these tools have their own flaws. Therefore, the model’s performance in a real-world data environment is likely to be affected.
A Study on Shield Design Aspects of a Semi-Industrial Co-60 Gamma Irradiation Facility at Gamma Source Division of Institute of Food and Radiation Biology of the Bangladesh Atomic Energy Commission
Authors: Ahmed S , Khan MJH , Nahar A , Mortuza MF , Hosan MI 
Published: December 2022

The aim of this work is to investigate the existing shield design aspects of a semi-industrial Cobalt- 60 Gamma Irradiation Facility for 100 kCi, designed for irradiation of pharmaceutical products and daily foodstuffs as well as for research and development purposes at the Institute of Food and Radiation Biology (IFRB) of the Bangladesh Atomic Energy Commission. Earlier, the initial activity of this facility was 65 kCi and stone based reinforced concrete (SBRC) of density 2.60 g/cc and specific thicknesses were used to shield the facility for safety to operational personnel and outside public. Due to a large demand for irradiation of pharmaceutical products as well as of daily foodstuffs, IFRB has decided to increase the initial activity up to 100 kCi for this facility. For this reason, the shielding design aspects of this facility were needed to be recalculated and checked for safety. This analysis was done using the Point-kernel Shielding Code Micro-Shield 5.05 and public domain Point-kernel Shielding code QAD-CGGP2 respectively considering the radiation worker dose limit of 10 μSv/hr of the International Commission on Radiological Protection, ICRP-60, 1990. The corresponding dose limit for public at large is 0.5 μSv/hr. The calculated dose rates at different locations around the facility are far below 10 μSv/hr except in one area. This location is inside the source room. No one is allowed to enter the room when the facility is in the ON mode. However, except one location, positions outside the facility have dose rates about 3 time higher than 0.5 μSv/hr, the dose limit for public at large. Therefore, this analysis shows that the existing shield design aspects of IFRB’s Co-60 gamma source room is safe for a 100 kCi source from the viewpoint of radiation safety to operating personnel but not for public at large within proximity of the facility.
Bangladesh Journal of Medical Physics Vol.15 No.1 2022 P 1-7
Detection of Schizophrenia from EEG Signals using Dual Tree Complex Wavelet Transform and Machine Learning Algorithms
Authors: Antara Fahmida Ahmed , Arefin ASM Shamsul , Rayhan Md Tamjid , Chowdhury Sabbir Ahmed 
Published: December 2022

This research was conducted with the aim to detect schizophrenia automatically from EEG signals using machine learning algorithms. The 16 electrode EEG data were collected from the online repository where 43 schizophrenic and 39 healthy persons’ dataset is available. By applying Low Pass Filter and Total Variation Denoising method, raw EEG signals were denoised and were decomposed into beta, alpha, theta and delta waves by using Dual Tree Complex Wavelet Transform. To apply machine learning algorithms, five features: mean, median, standard deviation, energy and kurtosis were considered for all the four wave bands. With Linear Support Vector Machine and Random Forest classifier machine learning algorithms, 12 out of 16 channels were classified with test accuracy above 95% and F1 score above 90%. Among them, 7 channels were predicted with 100% test accuracy. This research thus has the potential to detect schizophrenia unsupervised and within a noticeably short period of time giving the opportunity to real time monitoring of patients. Hence, people living in remote areas or deprived of adequate healthcare professionals can be benefitted through the outcome of this research.
Bangladesh Journal of Medical Physics Vol.15 No.1 2022 P 8-27