bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motivational interviewing for preventing oral morbidities in adults: Systematic review and meta‐analysis
Authors: Cartes‐Velásquez Ricardo , Varnet‐Pérez Tomás , Martínez‐Delgado Cecilia María , Villanueva‐Vilchis María del Carmen , Ramírez‐Trujillo María de los Ángeles , Faustino‐Silva Daniel Demétrio 
Published: September 2023

AbstractObjectiveThis systematic review with meta‐analysis was performed to assess whether motivational interviewing (MI) effectively prevents oral morbidities in adults.MethodsStudies considered were randomized controlled trials, cluster‐randomized controlled trials and community‐based randomized trials assessing interventions based on MI or indicating that a counselling technique based on the principles developed by Miller and Rollnick was used. Controls were any type of oral health education or negative controls. Participants were 18–60 years old. The main outcome was any oral morbidity. From 602 studies identified in MEDLINE, Scopus, Web of Science and LILACS databases, seven studies were included in the synthesis.ResultsStudies included only evaluated periodontal outcomes, no studies were found for other oral morbidities. Patients' mean age was 43.7 years, and the follow‐up time after MI or MI‐based intervention varied between 1 month and 1 year. The total study population was 272 people with moderate‐to‐severe periodontitis; other groups analysed were pregnant women (n = 112) and patients with mental disorders and alcohol problems (n = 60). Meta‐analysis for the plaque index (four studies, n = 267), bleeding on probing (two studies, n = 177) and gingival index (two studies, n = 166) were carried out. The summary effects for the random‐effects model were estimated respectively as −3.59 percentage points (CI: [−11.44; 4.25] for plaque index, −6.41 percentage points (CI: [−12.18, −0.65]) for bleeding on probing and −0.70 (CI: [−1.87; 0.48]) for gingival index, marginally favouring the MI group. The reduced number of studies, the non‐disclosure of some aspects of the data and the heterogeneity among them undermine the precision of the estimates.ConclusionThe current evidence available is limited to periodontal outcomes, and it is not possible to determine whether MI effectively prevents oral morbidities in adults.
Genetically predicted plasma cortisol and common chronic diseases: A Mendelian randomization study
Authors: Lee Wei‐Hsuan , Larsson Susanna C. , Wood Angela , Di Angelantonio Emanuele , Butterworth Adam S. , Burgess Stephen , Allara Elias 
Published: September 2023

AbstractObjectiveCushing's syndrome is characterized by hypercortisolaemia and is frequently accompanied by comorbidities such as type 2 diabetes, hypertension, osteoporosis, depression and schizophrenia. It is unclear whether moderate but lifelong hypercortisolaemia is causally associated with these diseases in the general population. We aimed to address this research gap using a Mendelian randomization approach.MethodsWe used three cortisol‐associated genetic variants in the SERPINA6/SERPINA1 region as genetic instruments in a two‐sample, inverse‐variance‐weighted Mendelian randomization analysis. We obtained summary‐level statistics for cortisol and disease outcomes from publicly available genetic consortia, and meta‐analysed them as appropriate. We conducted a multivariable Mendelian randomization analysis to assess potential mediating effects.ResultsA 1 standard deviation higher genetically predicted plasma cortisol was associated with greater odds of hypertension (odds ratio: 1.12; 95% confidence interval [CI]: 1.05–1.18) as well as higher systolic blood pressure (mean difference [MD]: 0.03 SD change; 95% CI: 0.01–0.05) and diastolic blood pressure (MD: 0.03 SD change; 95% CI: 0.01–0.04). There was no evidence of association with type 2 diabetes, osteoporosis, depression and schizophrenia. The association with hypertension was attenuated upon adjustment for waist circumference, suggesting potential mediation through central obesity.ConclusionThere is strong evidence for a causal association between plasma cortisol and greater risk for hypertension, potentially mediated by obesity.
Drug–drug interaction prediction of ziritaxestat using a physiologically based enzyme and transporter pharmacokinetic network interaction model
Authors: Perrier Jeremy , Gualano Virginie , Helmer Eric , Namour Florence , Lukacova Viera , Taneja Amit 
Published: September 2023

AbstractZiritaxestat, an autotaxin inhibitor, was under development for the treatment of idiopathic pulmonary fibrosis. It is a substrate of cytochrome P450 3A4 (CYP3A4) and P‐glycoprotein and a weak inhibitor of the CYP3A4 and OATP1B1 pathways. We developed a physiologically based pharmacokinetic (PBPK) network interaction model for ziritaxestat that incorporated its metabolic and transporter pathways, enabling prediction of its potential as a victim or perpetrator of drug–drug interactions (DDIs). Concurrently, we evaluated CYP3A4 autoinhibition, including time‐dependent inhibition. In vitro information and clinical data from healthy volunteer studies were used for model building and validation. DDIs with rifampin, itraconazole, voriconazole, pravastatin, and rosuvastatin were predicted, followed by validation against a test dataset. DDIs of ziritaxestat as a victim or perpetrator were simulated using the final model. Predicted‐to‐observed DDI ratios for the maximum plasma concentration (Cmax) and the area under the plasma concentration–time curve (AUC) were within a two‐fold ratio for both the metabolic and transporter‐mediated simulated DDIs. The predicted impact of autoinhibition/autoinduction or time‐dependent inhibition of CYP3A4 was a 12% decrease in exposure. Model‐based predictions for ziritaxestat as a victim of DDIs with a moderate CYP3A4 inhibitor (fluconazole) suggested a 2.6‐fold increase in the AUC of ziritaxestat, while multiple doses of a strong inhibitor (voriconazole) would increase the AUC by 15‐fold. Efavirenz would yield a three‐fold decrease in the AUC of ziritaxestat. As a perpetrator, ziritaxestat was predicted to increase the AUC of the CYP3A4 index substrate midazolam by 2.7‐fold. An overarching PBPK model was developed that could predict DDI liability of ziritaxestat for both CYP3A4 and the transporter pathways.
Cutaneous rhabdomyosarcoma with FUS::TFCP2 fusion: A case report emphasizing early detection
Authors: Demirkesen Cuyan , Danyeli Ayça Erşen , Yıldız Pelin , Ertekin Sümeyre Seda , Yılmaz Berkhan , Karahan Süleyman İzzet , Bahrami Armita 
Published: September 2023

AbstractRhabdomyosarcoma with TFCP2 rearrangement is a recently identified malignant neoplasm characterized by immunohistochemical evidence of rhabdomyoblastic differentiation, keratin expression, upregulation of ALK, and an aggressive clinical course. This neoplasm has a tendency to affect craniofacial bones, with only a few reported cases of extra‐osseous tumors. Here, we present a case of cutaneous rhabdomyosarcoma with FUS::TFCP2 fusion in a 35‐year‐old female. Notably, the tumor exhibited a pathologic spectrum, initially resembling sclerosing dermatitis at presentation but progressing into a high‐grade malignant tumor within 8 months. The distinctive immunoprofile of this neoplasm highlights the importance of early molecular studies for diagnosis, even in the presence of low‐grade cytomorphology. Early detection may offer an opportunity for timely resection before the tumor becomes unresectable.
Cytological features of diffuse and circumscribed gliomas
Authors: Esteban‐Rodríguez Isabel , López‐Muñoz Samuel , Blasco‐Santana Luis , Mejías‐Bielsa Jaime , Gordillo Carlos H. , Jiménez‐Heffernan José A. 
Published: September 2023

AbstractThe current World Health Organization classification of gliomas is based on morphological, genetic, and molecular parameters. In this review, we intend to present the most relevant cytological features of these tumours, with a particular focus on their analysis during intraoperative studies. Rapid diagnosis is required in this context, and at present it is not possible to evaluate the genetic or molecular profile of a tumour intraoperatively. New terminology and diagnostic parameters have been introduced, but the essence of intraoperative recognition remains the same. The main challenge in astrocytoma IDH‐mutant, grade 2 is recognising the tissue as neoplastic. Since glioma grades 3 and 4 are assigned based on histological and genetic variables that are not necessarily measurable on cytology, the term high‐grade glioma is often used for intraoperative diagnosis. Oligodendroglioma, IDH‐mutant and 1p/19q‐codeleted shows peculiar cytological findings as well as the common subtypes of glioblastoma IDH‐wildtype (giant cell, epithelioid, gliosarcoma and small cell). Many of the paediatric‐type‐diffuse gliomas have been described very recently and there are no cytological reports of proven cases. Finally, pilocytic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, chordoid glioma, and astroblastoma MN1‐altered constitute the group of circumscribed astrocytic gliomas. They are remarkable entities that the pathologist must be able to recognise since most are low‐grade neoplasms that can show atypical morphological features.
Fetal alcohol spectrum disorder and Aboriginal and Torres Strait Islander men: A discussion to be had
Authors: Doyle Michael F. , Perry Jimmy , Bower Carol , Conigrave Katherine M. , Hamilton Sharynne 
Published: September 2023

AbstractFetal alcohol spectrum disorder (FASD) is a lifelong disability of varying severity that occurs among individuals prenatally exposed to alcohol. Among Aboriginal and Torres Strait Islander (Indigenous) Australians, the effects of colonisation and ongoing racism could increase the risk of alcohol consumption during pregnancy. Much of the research and the effort towards prevention of and caring for people with FASD in Indigenous communities has been targeted towards women and children. More support and effort towards prevention of FASD is needed across the whole Indigenous community. In this paper, we discuss several areas for increased involvement by Indigenous men in future FASD research, prevention, care and support.
Efficacy and safety of once‐weekly versus once‐daily basal insulin analogues in the treatment of type 2 diabetes mellitus: A systematic review and meta‐analysis
Authors: Karakasis Paschalis , Patoulias Dimitrios , Pamporis Konstantinos , Popovic Djordje S. , Stachteas Panagiotis , Bougioukas Konstantinos I. , Fragakis Nikolaos , Rizzo Manfredi 
Published: September 2023

AbstractAimTo summarize the evidence of recently published randomized controlled trials (RCTs) studying efficacy, in terms of glycaemic control, and safety of the newly developed once‐weekly basal insulin analogues.MethodsA systematic literature search was conducted through Medline (via PubMed), Cochrane Library and Google Scholar until June 30, 2023. Double‐independent study selection, data extraction and quality assessment were performed. Results were summarized with random‐effects meta‐analysis.ResultsA total of 3962 patients with type 2 diabetes mellitus (T2DM) among nine RCTs were analysed. All RCTs had low risk of bias according to the Cochrane Collaboration risk‐of‐bias tool (RoB2). Once‐weekly insulins demonstrated better efficacy in glycated haemoglobin (HbA1c) reduction (mean difference [MD] −0.13%, 95% confidence interval [CI] −0.23, −0.03; P = 0.08) and a significantly greater time in range compared with once‐daily insulin analogues (MD 3.54%, 95% CI 1.56, 5.53; P = 0.005). Based on subgroup analyses, the reduction in HbA1c and the odds of achieving an end‐of‐treatment HbA1c <6.5% were significantly greater for icodec compared to the once‐daily insulin (MD −0.18%, 95% CI −0.27, −0.09 [P < 0.001] and odds ratio [OR] 1.75, 95% CI 1.34, 2.29 [P < 0.001], respectively). Once‐weekly insulins were associated with higher odds of level 1 hypoglycaemia during the 24‐hour period (OR 1.3, 95% CI 1.04, 1.64; P = 0.02) but were safer in terms of level 2 or 3 nocturnal hypoglycaemic events (OR 0.74, 95% CI 0.56, 0.97; P = 0.03). No difference was observed regarding serious adverse events between the two groups.ConclusionThe once‐weekly basal insulin analogues seem to be at least equally efficient in glycaemic management and safe compared to once‐daily injections in people with T2DM. Phase 4 RCTs are expected to shed further light on the effectiveness and safety of once‐weekly insulin therapy over the long term.
The gastropod Lottia peitaihoensis as a model to study the body patterning of trochophore larvae
Authors: Huan Pin , Liu Baozhong 
Published: September 2023

AbstractThe body patterning of trochophore larvae is important for understanding spiralian evolution and the origin of the bilateral body plan. However, considerable variations are observed among spiralian lineages, which have adopted varied strategies to develop trochophore larvae or even omit a trochophore stage. Some spiralians, such as patellogastropod mollusks, are suggested to exhibit ancestral traits by producing equal‐cleaving fertilized eggs and possessing “typical” trochophore larvae. In recent years, we developed a potential model system using the patellogastropod Lottia peitaihoensis (= Lottia goshimai). Here, we introduce how the species were selected and establish sources and techniques, including gene knockdown, ectopic gene expression, and genome editing. Investigations on this species reveal essential aspects of trochophore body patterning, including organizer signaling, molecular and cellular processes connecting the various developmental functions of the organizer, the specification and behaviors of the endomesoderm and ectomesoderm, and the characteristic dorsoventral decoupling of Hox expression. These findings enrich the knowledge of trochophore body patterning and have important implications regarding the evolution of spiralians as well as bilateral body plans.
Caste composition contributes to improve the social immunity in a nasute termite species exposed to entomopathogenic fungus
Authors: Freitas Ferreira Larissa , Silva Cátila R. , Santos Renan E. C. , C. Moreira Camila , F. Cristaldo Paulo 
Published: September 2023

Abstract
The evolution of a reproductively altruistic caste contributed to the success of eusociality through the division of labour. In termites, the proportion of soldiers in the colonies increased throughout the group's evolution. In Nasutitermitinae, soldiers have a crucial role in defence, resource selection and foraging. However, the role of soldiers and workers in colony immunity is still poorly understood.
Here, we evaluated the role of mixed caste groups in the social immunity of Nasutitermes corniger (Termitidae: Nasutitermitinae) exposed to the entomopathogenic fungi Metarhizium anisopliae (Metsch.). We tested the hypothesis that the presence of workers and soldiers optimizes defence against pathogens, and this defence is increased when the soldier ratio is closer to what naturally occurs in colonies.
Our results showed that mixed caste groups of N. corniger exposed to M. anisopliae survive longer compared to groups with only one caste. In addition, termite groups that died from fungi were less likely to show fungal infection in mixed caste groups.
The behavioural observations suggest that in the natural proportion of soldiers, allogrooming and trophallaxis play a crucial role in the control of disease and its death hazard in termites. Soldiers may play an important role in colony immunity, being able to start the alarm signal indicating the threat of pathogens.
Our results show that the presence of the two castes promotes possible mechanisms for socially mediated immunity. This study may help in the understanding of the function of the soldiers and workers and the significance of pathogens in termite eusocial evolution.
New observations on occurrence and distribution of Bursaphelenchus spp. (Nematoda: Aphelenchoididae) in conifers in Romania
Authors: Mitrea‐Călin Monica , Inácio Maria L. , Costache Claudia , Nóbrega Filomena , Mota Manuel , Cristea Stelica , Braasch Helen 
Published: September 2023

AbstractSix species of the genus Bursaphelenchus were recovered as the result of a survey to assess the potential introduction of Bursaphelenchus xylophilus into the conifer forests of Romania. Bursaphelenchus xylophilus was not detected in the sampling regions. Bursaphelenchus dietrichi was recovered from one point, representing the first report of this species in the country. The other detected species, B. abietinus, B. andrassyi, B. hofmanni, B. fraudulentus and B. willibaldi, were characterized by their morphometric data and molecular analyses. The morphometrics of Romanian populations of B. hofmanni and B. willibaldi are presented for the first time. The phylogenetic relationships of the recovered species (except for B. abietinus, with no successful sequencing) were reconstructed using the sequences of the D2‐D3 expansion segments of the large subunit of ribosomal DNA (D2‐D3LSU rDNA). Some of the species were also characterized using the restriction fragment length polymorphism (RFLP) pattern of the internal transcribed spacer (ITS) fragment. The distribution, related host trees and phylogenetic relationships of the identified species are discussed.
Association of iron therapy with incidence of chronic kidney disease
Authors: Shrestha Prabin , Paul Shejuti , Sumida Keiichi , Thomas Fridtjof , Surbhi Satya , Naser Abu Mohd , Streja Elani , Rhee Connie M. , Kalantar‐Zadeh Kamyar , Kovesdy Csaba P. 
Published: September 2023

AbstractObjectiveWe investigated the association of oral iron replacement with the incidence of chronic kidney disease (CKD) in a population with normal kidney function to study the effects of iron replacement on the development of new onset CKD.MethodsIn a national cohort of US Veterans with no pre‐existing CKD, we identified 33 894 incident new users of oral iron replacement and a comparable group of 112 780 patients who did not receive any iron replacement during 2004–2018. We examined the association of oral iron replacement versus no iron replacement with the incidence of eGFR <60 mL/min/1.73 m2 and the incidence of urine albumin creatinine ratio (UACR) ≥30 mg/g in competing risk regressions and in Cox models. We used propensity score weighing to account for differences in key baseline characteristics associated with the use of oral iron replacement.ResultsIn the cohort of 146 674 patients, a total of 18 547 (13%) patients experienced incident eGFR <60 mL/min/1.73 m2, and 16 117 patients (11%) experienced new onset UACR ≥30 mg/g. Oral iron replacement was associated with significantly higher risk of incident eGFR <60 mL/min/1.73 m2 (subhazard ratio, 95% confidence interval [CI]: 1.3 [1.22–1.38], p < .001) and incident albuminuria (subhazard ratio, 95% CI: 1.14 [1.07–1.22], p < .001).ConclusionOral iron replacement is associated with higher risk of new onset CKD. The long‐term kidney safety of oral iron replacement should be tested in clinical trials.
A call for health justice: Striving toward health equity at a community health center
Authors: Waite Roberta , Nardi Deena A. 
Published: September 2023

AbstractCommunity health centers play a key role in promoting health justice and equity. Health justice, which is the attainment of health equity, or the fair, unambiguous, and non‐arbitrary distribution of all health resources necessary for optimal health of the individual, family, and community, is necessary to optimize their wellbeing and to build healthy communities. Community‐based health centers are well‐positioned to lead in these efforts, as they connect with, seek to understand, and innovatively serve communities that experience complex health‐related needs and are differentially impacted by structural vulnerabilities (i.e., racism). The purpose of this article is to present a nurse‐led model of culturally responsive health care that is rooted in partnerships designed to address medical and health‐related social needs. Current health inequities in the United States across constructs of race and socioeconomic status warrant comprehensive healthcare models that explicitly incorporate health justice, trauma‐informed, and antiracist approaches into practice, especially when serving high/complex‐need and under‐resourced communities. Foundationally, it is imperative that these models of care strive toward equity regarding access to compassionate, affordable, culturally relevant health care; center community members' voices and guidance; promote growth and development of staff in understanding structural barriers and act to dismantle them; and create learning opportunities for students and staff to understand and address social determinants of health to provide high‐quality care, with an ultimate goal to improve community health.
Improved creep‐fatigue and remnant tensile/creep properties of 321 stainless steel by self‐healing coating
Authors: Li Wei , Qin Houjun , Zhu Shunpeng , Bo Guowei , Sun Tao , Jiang Dapeng , Chen Hui , Peng Xulong , Chen Jian , He Jianjun , Ni Song , Xiao Canjuan , Zhang Shengde , Chen Anqi 
Published: September 2023

AbstractAISI 321 steels used as intake valves in turbines are frequently subjected to creep‐fatigue (C‐F) exposure during service. Improving C‐F resistance and assessing remnant creep/tensile properties are therefore required for their safe service. In this work, the self‐healing coating consisting of Al2O3‐13TiO2 layer, TiC layer, and NiCrAlY layer was prepared for 321 steel. The effects of such self‐healing coating on the C‐F and remnant creep/tensile properties were studied. The results showed that the initial hardening phenomena of the studied steel during C‐F exposure was mainly attributed to the dislocation strengthening and a certain level of carbides precipitation strengthening, while the subsequent softening behaviors were resulted from dynamic recovery and coarsening of carbides. Moreover, as compared to other coatings, the self‐healing coating is able to improve the mechanical properties of steels due to dislocation strengthening, precipitation strengthening, and the self‐healing behavior resulting from the reaction between the TiC layer and oxygen.
Ceramic bodies without warping using epoxide–acrylate hybrid ceramic slurry for photopolymerization‐based 3D printing
Authors: Seo Haeun , Kim Haeun , Choi Hyeryang , Kim Dong Gyeong , Galbadrakh Altantsetseg , Jung Yeon‐Gil , Son Jung‐Hun , Yeo Jeong‐gu , Heo So Yeon , Choe Gyu‐Bin , Kim Gyu‐Nam , Koh Young‐Hag , Park Hye‐Yeong , Yang SeungCheol 
Published: September 2023

AbstractTo be able to produce ceramic bodies with complex shapes without interlayer delamination and warping through vat photopolymerization‐based 3D printing techniques, photosensitive ceramic slurries should be studied to prepare 3D printed green and sintered bodies. In this study, we developed dual curable acrylate–epoxide ceramic slurries for digital light processing (DLP) 3D ceramic printing. The dual curing process of the slurries is a combination of photo‐radical polymerization of acrylate and thermal cationic polymerization of cyclo‐aliphatic epoxide. The green bodies prepared by dual curing of the slurries showed higher fracture strength and better adhesion between layers and between starting particles and binder polymer in comparison to acrylate‐based green body. These advantages were due to higher crosslinking density of the binder matrix and hydrogen bonding by hydroxyl groups from epoxide ring opening. The green and sintered bodies printed with improved slurry and DLP 3D printer had flat shape without warping unlike those from acrylate‐based bodies. Moreover, the distribution of inter‐particle necking in the sintered body was uniform and the interface boundary between layers was not observed. This is because of excellent uniformity of the dual cured acrylate–epoxide polymer matrix (uniform crosslinking density in layers) in the green body and hydroxyl groups generated by epoxy ring opening.