bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly oxidized albumin is mainly cleared by mouse liver sinusoidal endothelial cells via the receptors stabilin-1 and -2
Authors: Holte Christopher F. , Szafranska Karolina J. , Kruse Larissa D. , Simon-Santamaria Jaione , Li Ruomei , Svistounov Dmitri , McCourt Peter A.G. 
Published: July 2023

AbstractBackgroundOxidized albumin (oxHSA) is elevated in several pathological conditions, especially those involving the liver, such as decompensated cirrhosis, acute on chronic liver failure and liver mediated renal failure. Patient derived oxidized albumin was previously shown to be an inflammatory mediator in cultured endothelial cells and leukocytes. The removal from circulation of oxidized albumins is therefore essential for maintenance of homeostasis. Normal serum levels of oxidized albumin are low, implying it is constantly eliminated. Liver sinusoidal endothelial cells (LSEC) are prominent scavenger cells in the body, specializing in the removal of macromolecules e.g. hyaluronan, denatured collagen, modified albumins, bacterial endotoxin (LPS) and oxidized lipoprotein. Given that oxidized albumin is mainly cleared by the liver, we hypothesize the LSEC are the site of uptake in the liver. Furthermore the stabilins -1 and -2 are the most prominent candidates for oxHSA uptake receptors, given their expression pattern and uptake of other ligands.MethodsIn vivo biodistribution, hepatocellular distribution and in vitro uptake studies on isolated liver cell populations or receptor expressing cell lines.ResultsIn vivo oxHSA was cleared rapidly (t1/2 <90seconds) by the liver (47% of uptake) and distributed to mainly the LSEC. In in vitro studies LSEC endocytosed oxHSA much more than other cell populations isolated from the liver. Furthermore, it was shown that the uptake was mediated by the stabilins, by inhibiting uptake in LSEC with other stabilin ligands and showing uptake in HEK cells overexpressing stabilin-1 or 2. oxHSA also inhibited the uptake of other stabilin ligands.ConclusionsLSEC and their stabilins are vital for the clearance of oxidized albumin, and therefore play a pivotal role in maintaining homeostasis.
A study on bubble suppression for deep marine reflection data acquired by a small airgun array
Authors: Li Zhehao , Zhou Hua‐Wei , Ma Guangkai , Cai Dongdi , Cao Mingqiang 
Published: July 2023

AbstractThe oscillatory bubble pulses generated by airguns in seawater are known to produce artefacts in seismic images. Although such artefacts are suppressible by employing larger airgun arrays in acquisition, small airgun arrays are used more often now to minimize the environmental impacts, thus raising the need for further suppressing bubble pulses at data processing stage. For a deep marine reflection dataset recently acquired by a small airgun array, we compare the effectiveness of three popular debubbling methods that estimate the far‐field source signature based on theoretical simulation and wavelets extracted from seafloor reflections and direct arrivals, respectively. In this case, due to the lack of near‐field measurements for calibration, the debubbling via simulation underperforms the two wavelet extraction methods. Overlapping events in the noisy response of seafloor sediments lead to the failure of the wavelet extraction from primary seafloor reflections. The estimated source signature based on direct arrivals achieves the best bubble suppression result, indicating the importance of signal‐to‐noise ratio and a low level of directionality of the small airgun array source.
Legislative performance and the electoral connection in European Parliament elections
Authors: CHIRU MIHAIL 
Published: July 2023

AbstractThe absence of an electoral connection is a widely held assumption in the scholarship on the European Parliament (EP) and a cause of serious normative concern about the functioning of the European Union. Weak individual legislator accountability is part of this assumption, even if we still know little about the extent to which legislative performance matters for citizens in EP elections that allow preferential voting. This study is the first to analyse how legislative performance influences the preference vote shares of members of the European Parliament (MEPs) and whether this is moderated by their parties’ EU salience and incumbent intra‐party competition. It draws on an original dataset that combines candidate and electoral data from three rounds of EP elections held between 2004 and 2014 under open or flexible list rules with information on individual legislative activity (i.e., number of reports, parliamentary questions and speeches) and leadership positions at EP and committee level. One dimension of legislative performance, report writing, is associated with a larger share of preference votes but only for incumbents of parties assigning high salience to the EU. While MEPs win a higher share of preference votes when they face limited co‐partisan incumbent competition, this factor does not moderate the electoral connection.
Functional interferon‐epsilon gene polymorphisms and sexually transmitted infections of the endometrium
Authors: Taylor Brandie DePaoli , Criscitiello Michael F. , Bazer Fuller W. , Richardson Lauren S. , Noah Akaninyene , Haggerty Catherine L. 
Published: July 2023

AbstractProblemInterferon‐epsilon (IFNε) is the only type I IFN constitutively expressed in the female reproductive tract and fluctuates across the menstrual cycle in humans. Mouse models show that IFNε protects against Chlamydia trachomatis, Herpes Simplex Virus, HIV, and Zika in mice, but human studies are limited. Bacterial sexually transmitted infections (STI) can ascend to the upper genital tract and cause pelvic inflammatory disease (PID) and subsequent infertility. However, the host immunological mechanisms that play a role in the ascension and infection of the endometrium in individuals with clinically suspected PID are not elucidated.Method of studyThis pilot investigation determined if IFNε gene variants are associated with bacterial vaginosis (BV) and endometrial infection with C. trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium using biospecimens from 154 self‐report Black individuals who participated in the PID Evaluation and Clinical Health (PEACH) study.ResultsThe T allele for rs2039381 was associated with endometrial STI infection (OR 2.7, 95% CI: 1.0‐7.1) and the C allele for rs1125488 was inversely associated with BV (OR: .2, 95% CI: .05‐.8).ConclusionsFew studies have examined IFNε gene variants, our study raises the possibility that IFNε gene variants may be a potential host contributor to STI pathogenesis.
The ribonuclease domain function is dispensable for SLFN11 to mediate cell fate decision during replication stress response
Authors: Qi Fei , Alvi Erin , Ogawa Minori , Kobayashi Junya , Mu Anfeng , Takata Minoru 
Published: July 2023

AbstractThe SLFN11 gene participates in cell fate decision following cancer chemotherapy and encodes the N‐terminal ribonuclease (RNase) domain and the C‐terminal helicase/ATPase domain. How these domains contribute to the chemotherapeutic response remains controversial. Here, we expressed SLFN11 containing mutations in two critical residues required for RNase activity in SLFN11−/− cells. We found that this mutant was still able to suppress DNA damage tolerance, destabilized the stalled replication forks, and perturbed recruitment of the fork protector RAD51. In contrast, we confirmed that the helicase domain was essential to accelerate fork degradation. The fork degradation by the RNase mutant was dependent on both DNA2 and MRE11 nuclease, but not on MRE11's novel interactor FXR1. Collectively, these results supported the view that the RNase domain function is dispensable for SLFN11 to mediate cell fate decision during replication stress response.
Some facts about concentrated labor markets in the United States
Authors: Handwerker Elizabeth Weber , Dey Matthew 
Published: July 2023

AbstractWe estimate employer concentration by occupation in the United States from 2003 to 2018. Findings include the following: (1) concentration is a characteristic of small labor markets; (2) patterns of concentrated employment differ from patterns of employment in very large employers, with overlap largely in the public sector; (3) the public sector and hospital industry play prominent roles in concentrated employment; (4) more concentrated labor markets are associated with slightly lower wages, only within the private sector.
Neural correlates of intelligence: ERP Components of temporary storage predict fluid intelligence over and above those of executive functions
Authors: Jia Yujie , Wang Tengfei , Schweizer Karl , Ren Xuezhu 
Published: July 2023

AbstractPrevious research has revealed that individuals with different levels of intelligence exhibit distinct patterns of event‐related potentials (ERPs) related to executive functions and temporary storage. However, there is a lack of studies investigating the relative contributions of these ERPs in predicting individual differences in fluid intelligence. This study aims to examine the extent to which ERPs associated with executive functions and temporary storage can predict individual differences in fluid intelligence. Special attention is given to determining whether electrophysiological activities of temporary storage can predict fluid intelligence after accounting for executive functions, and vice versa. Both executive attention and temporary storage were measured by two experimental tasks, while electroencephalographic data were collected simultaneously. Fluid intelligence was assessed by two established tests. To address previous inconsistencies due to small sample sizes, a relatively large sample of young adults (N = 136) was recruited. The results revealed that participants with lower fluid intelligence displayed larger P3 amplitudes in the executive functions and temporary storage tasks compared to those with higher fluid intelligence. Additionally, the amplitudes of frontal and parietal P3s elicited by both executive functions and temporary storage significantly predicted fluid intelligence. Interestingly, the frontal and parietal P3s associated with temporary storage predicted fluid intelligence beyond the contributions of executive functions, supporting the storage account of individual differences in fluid intelligence. This study provides an original and fresh understanding of how executive functions and temporary storage contribute to fluid intelligence, offering new insights into the neurocognitive mechanisms underlying intelligence.
Dissent against ‘Definition debates’ about Social Work
Authors: McGregor Caroline 
Published: July 2023

This commentary dissents against definition debates. I argue that ongoing discussion about what social work is needs to find a common ground of recognition. Arguments about the bifurcation, demise or “end of social work” are challenged. Starting with the position that social work operates on a necessarily contested and contradictory space, the case is made for a shared definition of social work as a “mediator in the social”. To stand up as a foundational definition for the diversity of social work worldwide, “mediation in the social” as described by Philp (1979) requires important updates to fit the complex “socials” of the 21st century. This necessitates a shift from the inclusion of Indigenous knowledge as an add-on to expansively identifying indigenous knowledge as a constant that underpins social work internationally. This definition needs to be founded on shared values and assumptions that capture the essence of social work such as citizenship, relational practices, human rights and social justice as expressed in diverse cultural contexts worldwide.
Influence of decentration of plate-haptic toric intraocular lens on postoperative visual quality
Authors: Diao Chunli , Lan Qianqian , Liao Jing , Lu Peng , Zhou Zhou , Li Lanjian , Zeng Siming , Yao Gang , Huang Wei , Chen Qi , Lv Jian , Tang Fen , Li Min , Xu Fan 
Published: July 2023

Abstract
Background
To evaluate the influence of decentration of plate-haptic toric intraocular lens (IOLs) on visual quality.

Methods
This study enrolled 78 eyes of 78 patients. Patients in group A were implanted with toric IOLs, and patients in group B were implanted with monofocal IOLs. All patients were divided into group A1 and B1 (decentration below 0.3 mm) and group A2 and B2 (decentration above 0.3 mm). The uncorrected distance visual acuity (UDVA), best corrected visual acuity (BCVA), modulation transfer function cutoff (MTF cutoff), objective scatter index (OSI), strehl ratio (SR), optical interference and patients’ satisfaction were measured in different pupils at three months postoperatively. The associations between decentration and visual quality were analyzed by Spearman correlation.

Results
There were no significant differences in UDVA, BCVA, MTF cutoff, OSI, SR, optical interference and patients’ satisfaction among subgroups. The differences in decentration between groups A and B were not statistically significant. In group A2, the total higher order aberrations (tHOAs) at pupil sizes of 3 mm (P = 0.046), 5 mm (P = 0.014), spherical aberrations at pupil sizes of 3 mm (P = 0.011), 4 mm (P = 0.014), 5 mm (P = 0.000), secondary astigmatism at pupil sizes of 3 mm (P = 0.002), 4 mm (P = 0.005) were higher than in group B2. Compared to group A1, group A2 had higher spherical aberrations at pupil sizes of 4 mm (P = 0.042), 5 mm (P = 0.001), 6 mm (P = 0.038), secondary astigmatism at pupil sizes of 3 mm (P = 0.013), 4 mm (P = 0.005), 6 mm (P = 0.013). Group B2 has higher coma and secondary astigmatism than group B1 at 6-mm pupil (P = 0.014, P = 0.045). Significant positive correlations were found between spherical aberrations and the decentration of group A1 and A2 at 6-mm pupils.

Conclusion
The decentration above 0.3 mm negatively affected visual quality due to increased tHOAs, spherical aberrations, coma and secondary astigmatism aberrations, the influence become larger with increasing pupil diameter. And toric IOLs are more affected by decentration than monofocal IOLs.
Achieving a robust mentoring and research capacity program in a LMIC – the BRAINS faculty development model
Authors: Ogunsola Folasade Tolulope , Sekoni Adekemi , Akanmu Alani Sulaimon , Adeyemo Wasiu Lanre , Osuntoki Akinniyi , Manga-Atangana Bibiane , Afolabi Bosede Bukola , Okubadejo Njideka Ulunma , Emmanuel Madonna , Caleb-Adepoju Sikeade Olawumi , Folarin Olalekan , Okonkwo Prosper , Murphy Robert L , Kanki Phyllis 
Published: July 2023

Abstract
Background
A research and training program (RTP) was carried out to build the capacity of faculty and improve the culture of research in the College of Medicine, University of Lagos (CMUL), Nigeria.

Methods
Realist-guided mixed methods evaluation of the BRAINS project was carried out using secondary data generated during the 5-years (2015 – 2020) of project implementation. Capacity building workshops and mentored research activities targeted at faculty in the CMUL were conducted. Overall, 1,418 participants attended the workshops in batches. Among the participants, forty-five faculty received grants and were mentored by senior professionals (local & international) to conduct research. Data were extracted from all project-related documents including coursework biodata, workshop evaluation forms, quarterly project reports, and end- of-project reports, submitted by the mentees, minutes of meetings, and the proposal submitted for funding. It was in the form of continuous variables and prose (sentences & stories). Quantitative data were analysed with IBM SPSS statistics version 20. Mean knowledge score and mean difference was calculated, paired t-test was carried out using p < 0.05 to determine statistical significance. The prose was thematically analysed to generate themes and narratives. Both were subsequently combined for interpretation and used to refine the initial programme theory into an evidence-informed theory.

Results
Twelve courses were deployed, and 1,418 participants (47.8% males and 52.2% females) from medical, nursing, and allied medical departments were trained. Eighty participants were trained in Responsible Conduct of Research and eighty-one on Manuscript Writing over three years. A comparison of the pre/post-test knowledge scores showed a positive mean difference. Thematic analysis of workshop data produced three thematic domains representing effectiveness and gains namely: cognitive, reward, and behavioural. 45 trainees were awarded grants and mentored, and analysis of mentee’s data generated 4 themes: Achieving a robust mentoring program; Benefits of the mentoring program; Resilience in research; Improving the mentoring program.

Conclusion
By contributing to the body of knowledge available on RTPs, this evaluation identified key components that contributed to the success of the project and developed a model for achieving a robust training and mentoring program which can be replicated in other LMICs.
Immunodeficiency due to a novel variant in PIK3CD: a case report
Authors: Shashaani Niloofar , Chavoshzadeh Zahra , Ghasemi Leila , Ghotbabadi Shabnam Hajiani , Shiari Sara , Sharafian Samin , Shiari Reza 
Published: July 2023

Abstract
Background
Primary immunodeficiencies are immunological disorders caused by gene mutations involved in immune system development and activation. Recently, activated phosphoinositide 3-kinase delta syndrome (APDS) due to mutations in the phosphoinositide 3-kinase (PI3K), phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit delta gene (PIK3CD), and phosphoinositide 3-kinase regulatory subunit 1 (PIK3R1) genes have been reported to induce a combined immunodeficiency syndrome leading to senescent T cells, lymphadenopathy, and immunodeficiency. The exact diagnosis of these deficiencies is essential for treatment and prognosis. In recent years, targeted treatment with selective PI3Kd inhibitors has had a significant effect on controlling the symptoms of these patients.

Case presentation
In this case report, we represent a 27-month-old girl with recurrent fever, an increased level of inflammatory markers, and erythema nodosum, who was referred to the rheumatology clinic. In the course of evaluations, because of the lack of clinical improvement with usual treatments, and a history of frequent respiratory infections, combined immunodeficiency was diagnosed in the immunological investigations. Moreover, whole-exome sequencing was performed for her.

Conclusion
The genetic analysis found a novel variant of PIK3CD (c.1429 G > A) in the patient. Following daily antibiotic prophylaxis and monthly IV therapy, the patient’s frequent infections and fevers were controlled.
Detection of Bartonella vinsonii, Anaplasma platys and Bartonella sp. in didelphis marsupialis, Pecari tajacu and Chelonoidis denticulate: Peru
Authors: Rojas-Jaimes Jesús , del Valle-Mendoza Juana 
Published: July 2023

Abstract
Introduction
Evidence suggest that wildlife Infectious diseases related to wildlife are of most importance because of the agents’ capacity to spill over into humans from the wild reservoir. Among them, the bacteria Bartonella spp. and Anaplasma spp. are related to this zoonotic dynamic.

Objective
The primary goal of the present study was to determine the presence of pathogenic bacteria in kidney and liver tissues of Didelphis marsupialis; spleen, liver, and skin of Pecari tajacu; spleen, liver, and skin of Chelonoidis denticulata.

Methodology
A PCR using universal and specific primers for 16 S rRNA, of Bartonella spp. with subsequent genetic sequencing were used.

Results
The results in this study indicate that Bartonella vinsonni was detected in the liver tissue of Didelphis marsupialis using both universal primers and those specific for Bartonella sp. Anaplasma platys was detected at the liver and spleen level using universal primers. Additionally, Bartonella spp. was found at the liver, spleen, and skin level in Pecari tajacu using the specific primers. Finally, using the universal and specific primers at the skin level, Bartonella spp. was evident in Chelonoidis denticulata.

Conclusions
The presence of the DNA of the Bartonella vinsonii was detected at the liver tissue in Didelphis marsupialis. DNA of the Anaplasma platys and Bartonella spp. were identified at the spleen and liver level. This study also identified that DNA Bartonella spp. was detected in Pecari tajacu skin. Finally DNA of Bartonella spp. was evident in Chelonoidis denticulate skin. The findings of this study suggest that these bacteria are present in these animals and may be responsible for outbreaks.
Commutability assessment of candidate reference materials for plasma renin activity measurement: current challenges
Authors: Liu Zhenni , Jin Lizi , Ma Zijia , Nizhamuding Xiaerbanu , Zeng Jie , Zhang Tianjiao , Zhang Jiangtao , Zhou Weiyan , Zhang Chuanbao 
Published: July 2023

Abstract

Objectives
This study aims to evaluate the commutability of external quality assessment (EQA) materials and candidate reference materials (RMs) for plasma renin activity (PRA) assay.

Methods
Commutabilities of 16 candidate RMs were measured along with 40 clinical samples by the four different routine PRA assays, including three LC‒MS/MS assays and one chemiluminescence immunoassay. Sixteen candidate RMs included native/spiked human plasma pools (small-scale pools with <50 individuals) and current EQA materials (large-scale pools with >1,000 individuals). Difference in bias approach and linear regression with prediction interval approach were adopted to determine the commutability. Two-way variance analysis was used to estimate the effects of spiked and pool size on the commutability. Stability and homogeneity studies were performed.

Results
Precision and correlation performance of all assays was acceptable. In the difference in bias approach, the commutability results were not satisfactory (noncommutability: 14/16) and significant sample-specific effects were detected in assay pairs using different incubation buffers. For the prediction interval approach, no commutability was observed in the spiked small-scale pools; EQA materials (4/9) had more satisfactory commutability among all assays than the small-scale pools (2/7); RMs of large-scale pools tend to have better commutability no matter spiked or not.

Conclusions
Commutable RMs were obtainable but challenging. Current EQA materials with relatively good commutability, stability, and homogeneity were appropriate RMs. Large-scale pools are tending to be commutable. Spiking in small-scale pools was not suggested to prepare RMs. MPs adopting a uniform incubation buffer would be preferable for further commutability research.
Testing a model of EFL teachers’ work engagement: the roles of teachers’ professional identity, L2 grit, and foreign language teaching enjoyment
Authors: Fathi Jalil , Zhang Lawrence Jun , Arefian Mohammad Hossein 
Published: July 2023

Abstract
Since teacher work engagement is argued to substantially affect education quality and learners’ performance, unveiling the factors affecting teacher engagement is of high significance. As an attempt to explore the antecedents of this construct in English-as-a-foreign-language (EFL) teachers, we tested a structural model of work engagement based on teachers’ professional identity, grit, and foreign language teaching enjoyment. A sample of 476 EFL teachers in Iran was requested to complete an online survey constituting the valid scales of the four constructs. Structural equation modeling (SEM) results indicated that the model fitted the data sufficiently. The model revealed that teachers’ grit, professional identity, and foreign language teaching enjoyment were the direct correlates of work engagement. Additionally, professional identity affected work engagement indirectly via foreign language teaching enjoyment and grit. Also, foreign language teaching enjoyment influenced work engagement through the mediation of grit. We conclude our study with a discussion on the implications of the findings.