bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cip2a induces arginine biosynthesis and promotes tumor progression in non‐small cell lung cancer
Authors: Chen Danyang , Fan Siwen , Wang Jun , Liang Yanqing , Li Pan , Lv Xinwu , Sun Yanqin , Wang Qian , Liu Hao , Zhang Chuantao , Yi Yanmei 
Published: January 2023

AbstractCancerous inhibitor of protein phosphatase 2A (Cip2a) is an oncoprotein, playing important roles in tumor progression. However, the underlying mechanisms by which Cip2a promotes tumor aggressiveness in NSCLC remain to be further investigated. In this study, we found that Cip2a expression is elevated in NSCLC and correlates with poor prognosis. Knockdown of Cip2a significantly reduced the ability of cell proliferation, invasion, and metastasis of NSCLC both in vitro and in vivo. Furthermore, we found that Cip2a promotes tumor progression partly by inducing arginine biosynthesis, and knockdown of Cip2a exhibited a significantly increased sensitivity to arginine deprivation and mTOR inhibition. In addition, we found that p53 mutants in NSCLC cells increased Cip2a expression by inhibiting the activity of wild‐type p53. Our findings provide new insights into the mechanisms of Cip2a in promoting tumor progression and suggest that Cip2a represents a potential therapeutic target for treating NSCLC.
The application of “S.I.S” technique improves long‐term continence after robotic radical prostatectomy
Authors: Song Qi‐Xiang , Li Jiayi , Shen Kai , Peng Zehong , Qiu Xudong , Zhu Hanjing , Gu Yiyuan , Xu Wenxin , Wang Jieying , Zhu Yinjie , Pan Jiahua , Dong Baijun , Xue Wei 
Published: January 2023

AbstractAimsTo propose a novel S.I.S technique during the robotic‐assisted radical prostatectomy (RARP), encompassing pubourethral suspension, posterior wall intensification, and bladder neck stripping, and to present functional and oncological outcomes with a special focus on long‐term continence.MethodsFrom January 1, 2018, to December 31, 2019, consecutive patients who underwent RARP were retrospectively investigated and separated into the S.I.S group and the conventional group. Preoperative patient characteristics, tumor status, and perioperative parameters were collected, followed by the assessment of self‐reported status on continence, using an International Consultation on Incontinence Modular Questionnaire—urinary incontinence short form (ICIQ‐UI‐SF). Statistical comparisons were performed on variables between the two surgery groups, and multivariate logistic regression analysis was used to determine predictive factors for postoperative incontinence severity.ResultsA total of 602 subjects were analyzed with a median follow‐up of 24 months. There was no significant difference regarding baseline characteristics and perioperative parameters, except for a more advanced tumor stage in the S.I.S group. The application of the S.I.S technique did not jeopardize the positive surgical margin rate at the bladder neck or long‐term tumor control. Notably, the patient‐reported degree of incontinence was significantly reduced with the assistance of S.I.S technique, as evidenced by the diminished severe‐to‐very severe cases. On multivariate analysis, both preoperative body mass index and use of S.I.S modification were independent predictive factors for the long‐term incontinence severity.ConclusionsThe application of S.I.S technique during RARP is feasible and superior compare with the conventional approach, with a significantly alleviated long‐term incontinence severity, without compromising cancer control.
Adverse Events Associated With Bioabsorbable Nasal Implants: A MAUDE Database Analysis
Authors: Wilkins Sarah G. , Sheth Amar H. , Kayastha Darpan , Abdou Hisham , Salehi Parsa P. , Citardi Martin J. , Peter Manes R. 
Published: January 2023

AbstractBioabsorbable implants (eg, Latera) have recently been approved for addressing nasal valve collapse. The purpose of this study is to summarize adverse events and treatment sequelae associated with bioabsorbable nasal implants queried in the Manufacturer and User Facility Device Experience (MAUDE) database. Of the 26 device reports entered between March 2017 and April 2022, the most frequently reported complications included abscess (n = 13) and implant protrusion (n = 5). Other common symptoms reported greater than 1‐year postimplantation included facial pain/discomfort (n = 3) and failure to absorb (n = 3). Management of adverse events included treatment with antibiotics (n = 9), steroid injections (n = 4), and explantation (n = 20). In 3 reports, adverse reactions required a biopsy of adjacent tissue for pathologic analysis. These findings suggest that further research is required to assess the potential long‐term complications and optimize the management of bioabsorbable nasal implants. Furthermore, standardized reporting templates may improve the utility of the MAUDE database.
Risk Factors for Recalcitrant Chronic Rhinosinusitis in Organ Transplant Recipients
Authors: Candelo Estephania , Avila‐Castano Karol , Verez Abigail , Abello‐Vaamonde Jorge A. , Donaldson Angela M. 
Published: January 2023

AbstractObjectiveStudies suggest that transplant patients are at risk for chronic rhinosinusitis (CRS). However, there is limited information in the literature regarding frequency and reasons for failure of adequate medical therapy. We aim to determine the risk factors associated with the development of medically recalcitrant CRS requiring endoscopic sinus surgery (ESS).Study DesignRetrospective cohort.SettingMayo Clinic.MethodsThis is a retrospective chart review of 925 transplant recipients seen at Mayo Clinic between 2017 and 2022. Inclusion criteria: (1) a rhinologic consultation after transplant and (2) clinical diagnosis of CRS. A total of 549 patients met the inclusion criteria and were divided based on the need for ESS versus successful treatment with medical therapy. Univariate and logistic regression analyses were performed to identify risk factors and predictive variables related to failure of medical therapy.ResultsOf the 549 patients, 201/549 (37%) had medically recalcitrant disease requiring ESS, while 348/549 (63%) were successfully treated with medical therapy Based on logistic regression, patients with recurrent acute rhinosinusitis in the pretransplant period were 8.68 more likely to have a recalcitrant disease (95% confidence interval, 3.72‐20.28, p < 0.0001). Some of the largest determinants of medical therapy failure in the posttransplant period were CRS with nasal polyps, odontogenic CRS, and noninvasive fungal sinusitis. The presence of neutropenia, aplastic anemia, and living transplant were also associated with medically recalcitrant CRS requiring ESS.ConclusionOur predictive model identifies with high accuracy the patients who may be at risk of developing recalcitrant CRS in the organ transplant population.
Comparison of Bacteriology Between Eosinophilic and Noneosinophilic Chronic Rhinosinusitis With Nasal Polyps
Authors: Jiang Rong‐San , Liang Kai‐Li 
Published: January 2023

AbstractObjectiveTo compare culture results between eosinophilic chronic rhinosinusitis (CRS) with nasal polyps (ECRSwNP) and noneosinophilic CRS with nasal polyps (nECRSwNP).Study DesignRetrospective study.SettingTertiary medical center.MethodsWe retrospectively analyzed a cohort of CRSwNP patients undergoing primary functional endoscopic sinus surgery. Prior to surgery, swab samples for bacterial culture were collected from their middle meatus using cotton tips. After surgery, postoperative specimens were histologically examined for tissue eosinophilia. A tissue eosinophil density of >10 cells at high power magnification was used to discriminate between ECRSwNP and nECRSwNP.ResultsA total of 295 patients were studied with polyps present on 471 sides of the nasal cavity. Among them, 236 sides were ECRSwNP, and the remaining 235 sides were nECRSwNP. Bacterial growth was found in 94 ECRSwNP sides, and in 88 nECRSwNP sides. Culture rates were similar between ECRSwNP and nECRSwNP sides (p = .595). However, Gram‐negative aerobes were found in 25 of 236 ECRSwNP sides, and in 42 of 235 nECRSwNP sides. The Gram‐negative culture rate was significantly higher in nECRSwNP than in ECRSwNP sides (p = .024).ConclusionThe bacteriology of CRS was different between ECRSwNP and nECRSwNP. The Gram‐negative aerobes were present more in nECRSwNP than in ECRSwNP.
Carbon fiber‐reinforced epoxy composite properties improvement by incorporation of polydopamine sizing at fiber–matrix interface
Authors: Qin Wenzhen , Lei Kaixuan , Yan Meiling , Li Zhongkai , Yan Yi , Hu Yongwei , Wu Zhijun , He Jianwei , Chen Liang 
Published: January 2023

AbstractTo gain better interfacial and mechanical performances of carbon fiber‐reinforced epoxy resin (CF/EP) composites, the surface modification of CF was carried out via a simple mild method. The polydopamine (PDA) was applied to size the CF, as well as the influence of PDA sizing time on CF was elucidated. As the PDA‐deposited time increases, a growing number of PDA nanoparticles were adhered on CF surface, associating with appearance of PDA agglomerates. Through analyzing the results, the optimum PDA sized time was 24 h. The introduction of PDA increases the chemical reaction and mechanical interlocking between fiber and matrix. Compared with unsized CF, the tensile strength of PDA 24 h sized CF was improved by 27.0%, the interlaminar shear strength, flexural and impact strength of PDA 24 h sized CF/EP composites increased by 103.7%, 65.6%, and 163.6%, respectively. Furthermore, the fracture topographies of CF/EP composite strikingly implied that the PDA has a positive impact on the mechanical performances of CF/EP composites.
The influence of self‐determination on the social functioning of long‐term day hospitals users with schizophrenia: A randomized controlled trial
Authors: Kinoshita Eiko , Hashimoto Takeshi , Nishimura Ryoji , Yotsumoto Kayano 
Published: January 2023

AbstractAimIn Japan, day hospitals are a method of rehabilitation for psychiatric disorders, especially for recovering social functioning. Currently, 60% of day hospital users have schizophrenia, the majority of whom are long‐term users (for over 1 year). However, they show no progress in community participation. This study aimed to investigate whether people with schizophrenia who use day hospitals can improve their social functioning and recovery levels, and alleviate psychiatric symptoms, when they engage in self‐determination regularly.MethodsThis study employed a multicenter randomized controlled design with a 3‐month intervention. Participants were divided into two groups. The intervention group (n = 24) determined their daily goals in life and attended the day hospitals' programs, while the control group (n = 25) only participated in the day hospitals' programs. Participants' social functioning was assessed using the Global Assessment of Functioning (GAF) scale, psychiatric symptoms using the Positive and Negative Syndrome Scale (PANSS), and recovery using the Recovery Assessment Scale (RAS), before and after the intervention.ResultsIn the intergroup factors, there were no significant differences in GAF, PANSS, or RAS scores.ConclusionThe results suggest that participants' regular self‐determination of their daily goals did not lead to significantly positive behavior in improving their social functioning. However, the social functioning and psychiatric symptoms of participants in day hospitals improved after 3 months.
Prenatal diagnosis of SMPD4 loss ‐ A neurodevelopmental disorder with microcephaly, arthrogryposis and structural brain anomalies
Authors: Theresia Koenigbauer Josefine , Wolfgang Henrich , Gundula Girschick , Michael Entezami , Alexander Weichert , Caroline Gabrysch , Laura Fangmann , Rabih Chaoui , Heinz‐Peter Gabriel 
Published: January 2023

AbstractSMPD4 loss is a rare neurodevelopmental disorder that leads to severe mental and physical disability and early death in infancy. Most cases of this genetic condition have been diagnosed postnatally. This article focuses on the prenatal findings of affected fetuses. The phenotypes can include growth restriction, arthrogryposis (clenched hands, foot deformity), as well as cerebral abnormalities (simplified gyral pattern/lissencephaly, cerebellar hypoplasia, corpus callosum deformity). SMPD4 loss is detectable via exome sequencing. Here, two fetuses displayed a homozygotic pathogen variant in the SMPD4 gene, encoding for the enzyme Sphingomyelinase‐4. Both parents were heterozygous carriers of the pathogenic variant. On detection of the above mentioned signs exome sequencing is indicated, with focus on the SMPD4 gene.
The influence of gratitude on depressive symptoms among Chinese college students during the COVID‐19 pandemic: The moderating effect of psychological capital
Authors: Luo Yun , Deng Yuting , Ma Tangsheng , Jiang Yan 
Published: January 2023

AbstractThe coronavirus disease 2019 outbreak has the potential to trigger declines in individual mental health, potentially in the form of depressive symptoms. However, few studies have explored factors protective of mental health during the ongoing pandemic. For the sustainable development of individual health, this study was conducted during the pandemic and examines the relationship between gratitude and symptoms of depression, as well as the moderating effect of psychological capital. Latent variable structural equation modeling was used to analyze depressive symptoms and protective factors in 3123 college students. This study measures gratitude, depressive symptoms, and psychological capital, using the Gratitude Scale, Patient Health Questionnaire‐9, and the Positive Psychological Capital Questionnaire, respectively. Gratitude was negatively related to depressive symptoms, with psychological capital as a moderator of the relationship. Specifically, psychological capital had a powerful protective effect against depressive symptoms. Students with high psychological capital had lower depressive symptoms than those with low psychological capital, regardless of their level of gratitude. In students with low psychological capital, gratitude had a protective effect against depressive symptoms. These findings suggest that psychological capital is a powerful protective factor against depressive symptoms during a pandemic and improving psychological capital could enhance mental health.
School‐based mental health supports during COVID‐19: School professional perspectives
Authors: Marraccini Marisa E. , Griffard Megan K. R. , Whitcomb Cason E. , Wood Caitlin , Griffin Dana C. , Pittleman Cari , Sartain Lauren 
Published: January 2023

AbstractThe present study explored the ways school professionals adapted school‐based mental health supports and services for remote delivery during the coronavirus disease 2019 (COVID‐19) pandemic. We surveyed 81 school professionals (e.g., counselors, psychologists, and social workers) and conducted in‐depth interviews with a subsample of professionals (n = 14) to explore their perceptions and experiences of supporting youth with mental health concerns and suicide‐related risk during the fall and winter of the 2020–2021 school year. Commonly endorsed school‐based mental health interventions (e.g., counseling services and checking in), ways of communicating (phone and email), and individuals delivering support and services to students with suicide‐related risk (e.g., counselors and teachers) were identified based on school professional survey responses. Qualitative findings point to facilitators (e.g., specific platforms for connecting with students and families) and barriers (e.g., limited communication) to successful service delivery during COVID‐19. Findings highlight the creative ways school support professionals adapted to provide school‐based mental health supports. Implications for remote school‐based mental health services during and following the pandemic are discussed.
Sequence‐controlled synthesis of rotaxanes
Authors: Han Han , Seale James S. W. , Feng Liang , Qiu Yunyan , Stoddart J. Fraser 
Published: January 2023

AbstractRotaxanes with well‐defined ring sequences are attractive synthetic goals in the construction of functional materials associated with molecular shuttles and switches, molecular electronics, and information storage. Sequence‐controlled synthesis of oligo‐ and polyrotaxanes is important in the context of the development of both sequence‐defined polymers and dynamic functional materials. To date, examples of sequence‐controlled rotaxanes are limited to oligorotaxanes on account of the synthetic challenges they pose. This Review sheds light on the pivotal role that sequence isomerism plays in rotaxanes. Synthetic approaches, including orthogonal templation, active‐metal templation, self‐sorting and snapping, cooperative‐capturing, ring‐through‐ring‐shuttling, and molecular pumping, for the construction of sequence‐controlled rotaxanes are all discussed in this Review. By comparing the advantages and disadvantages of these different approaches, several possible synthetic strategies are proposed in an attempt to foretell the future of sequence‐controlled synthesis of polyrotaxanes.
Endobronchial lesion in an adolescent with hemoptysis biopsy or not to biopsy?
Authors: Madhusudan Manoj , Srikanta Jingade Tukaram , Chandra Tejaswi , Karthik Kota , Balasubramanian Sundaram 
Published: January 2023

AbstractAn 11‐year‐old girl was brought with complaints of recurrent massive hemoptysis. A computerized tomography (CT) of the chest showed ground glass opacities on the right lower lobe, and a CT angiography showed hypertrophied right pulmonary artery. Flexible bronchoscopy revealed a sessile friable lesion in the right lower lobe, raising suspicion of either a tumor or a vascular malformation. An endobronchial ultrasound (EBUS) revealed a cystic lesion in the submucous plane, with vascularity noted on Doppler mode. This confirmed the diagnosis of bronchial Dieulafoy disease. A bronchial angiography revealed a vascular malformation overlying the lesion with a bronchopulmonary shunt, which was ligated. This case demonstrates the importance of EBUS in endobronchial lesions, to avoid biopsy of a vascular malformation.
Risk stratification for early biochemical recurrence of prostate cancer in the era of multiparametric magnetic resonance imagining‐targeted biopsy
Authors: Diamand Romain , Peltier Alexandre , Roche Jean‐Baptiste , Lievore Elena , Lacetera Vito , Chiacchio Giuseppe , Beatrici Valerio , Mastroianni Riccardo , Simone Giuseppe , Windisch Olivier , Benamran Daniel , Fourcade Alexandre , Nguyen Truong A. , Fournier Georges , Fiard Gaelle , Ploussard Guillaume , Roumeguère Thierry , Albisinni Simone 
Published: January 2023

AbstractBackgroundMultiparametric magnetic resonance imaging (MRI) and MRI‐targeted biopsy are nowadays recommended in the prostate cancer (PCa) diagnostic pathway. Ploussard and Mazzone have integrated these tools into novel risk classification systems predicting the risk of early biochemical recurrence (eBCR) in PCa patients who underwent radical prostatectomy (RP). We aimed to assess available risk classification systems and to define the best‐performing.MethodsData on 1371 patients diagnosed by MRI‐targeted biopsy and treated by RP between 2014 and 2022 at eight European tertiary referral centers were analyzed. Risk classifications systems included were the European Association of Urology (EAU) and National Comprehensive Cancer Network (NCCN) risk groups, the Cancer of the Prostate Risk Assessment (CAPRA) score, the International Staging Collaboration for Cancer of the Prostate (STAR‐CAP) classification, the Ploussard and Mazzone models, and ISUP grade group. Kaplan‐Meier analyses were used to compare eBCR among risk classification systems. Performance was assessed in terms of discrimination quantified using Harrell's c‐index, calibration, and decision curve analysis (DCA).ResultsOverall, 152 (11%) patients had eBCR at a median follow‐up of 31 months (interquartile range: 19–45). The 3‐year eBCR‐free survival rate was 91% (95% confidence interval [CI]: 89–93). For each risk classification system, a significant difference among survival probabilities was observed (log‐rank test p < 0.05) except for NCCN classification (p = 0.06). The highest discrimination was obtained with the STAR‐CAP classification (c‐index 66%) compared to CAPRA score (63% vs. 66%, p = 0.2), ISUP grade group (62% vs. 66, p = 0.07), Ploussard (61% vs. 66%, p = 0.003) and Mazzone models (59% vs. 66%, p = 0.02), and EAU (57% vs. 66%, p < 0.001) and NCCN (57% vs. 66%, p < 0.001) risk groups. Risk classification systems demonstrated good calibration characteristics. At DCA, the CAPRA score showed the highest net benefit at a probability threshold of 9%–15%.ConclusionsThe performance of risk classification systems using MRI and MRI‐targeted information was less optimistic when tested in a contemporary set of patients. CAPRA score and STAR‐CAP classification were the best‐performing and should be preferred for treatment decision‐making.
Observation of Robust Polarization Squeezing via the Kerr Nonlinearity in an Optical Fiber
Authors: Kalinin Nikolay , Dirmeier Thomas , Sorokin Arseny A. , Anashkina Elena A. , Sánchez‐Soto Luis L. , Corney Joel F. , Leuchs Gerd , Andrianov Alexey V. 
Published: January 2023

AbstractSqueezed light is one of the resources of photonic quantum technology. Among the various nonlinear interactions capable of generating squeezing, the optical Kerr effect is particularly easy‐to‐use. A popular venue is to generate polarization squeezing, which is a special self‐referencing variant of two‐mode squeezing. To date, polarization squeezing generation setups have been very sensitive to fluctuations of external factors and have required careful tuning. In this work, a development of a new all‐fiber setup for polarization squeezing generation is reported. The setup consists of passive elements only and is simple, robust, and stable. More than 5 dB of directly measured squeezing is obtained over long periods of time without any need for adjustments. Thus, the new scheme provides a robust and easy‐to‐set‐up way of obtaining squeezed light applicable to different applications. The impact of pulse duration and pulse power on the degree of squeezing is investigated.
Recurrent pleural effusion from ovarian hemangioma: A rare pseudo‐Meigs syndrome presentation
Authors: Neshat Sina , Yu Lee‐Mateus Alejandra , Fernandez‐Bussy Isabel , Walsh Katherine L. , Abia‐Trujillo David 
Published: January 2023

AbstractPleural effusion is a common condition related to various diseases such as heart failure, malignancies, and pneumonia. Ovarian hemangioma is a rare type of female genital tumour and can rarely cause pleural effusion. In this case, we present a 48‐year‐old female with repeated episodes of recurrent right‐sided pleural effusion over 1 year with no clear aetiology. Abdominal computed tomography revealed a large left ovarian mass. After surgical removal of the mass, the repeated pleural effusion episodes ceased, and histopathology analysis reported a rare ovarian hemangioma. Pseudo Meigs' syndrome is a triad of an ovarian tumour, ascites, and hydrothorax that rarely presents with ovarian hemangioma; both effusions are eradicated after removing the tumour.