bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seroprevalence of rubella virus infection among antenatal care clients of Halaba Town public health facilities, southern Ethiopia
Authors: Asrat Bedilu , Shimelis Techalew , Assefa Abiyu Ayalew , Hussen Siraj 
Published: May 2023

AbstractRubella virus infection during pregnancy has several effects on the developing fetus. However, little is known about the epidemiology of the infection in Ethiopia. A cross-sectional study was conducted to assess the seroprevalence of rubella virus infection on consecutive 299 pregnant women attending antenatal care clinics in public health facilities in Halaba Town, Southern Ethiopia. Structured questionnaires were used to collect information on socio-demographic and reproductive characteristics. Venous blood samples were collected, and sera were tested for anti-rubella IgM and IgG using the enzyme-linked immunosorbent assay. Anti-rubella IgG and IgM were detected in 265 (88.6%) and 15 (5.0%) of 299 participants, respectively. Pregnant women in their first trimester [crude odds ratio (cOR) = 4.26; 95% CI (1.47, 12.4)] were at increased risk of having anti-rubella IgM compared to those in their second and third trimesters. Urban residents [cOR = 4.06; 95% CI (1.94, 8.47)] were with a higher percentage of IgG positivity compared to rural residents. Anti-rubella IgG positivity was higher in housewives [cOR = 2.94; 95% CI (1.07, 8.04)] compared to self-employed women. Our findings showed a high prevalence of rubella virus exposure, and considerable percentages of recent infection and susceptible women to contracting the infection, emphasizing the importance of congenital rubella syndrome in the research area.
Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species
Authors: Ikhimiukor Odion O. , Souza Stephanie S. R. , Marcovici Michael M. , Nye Griffin J. , Gibson Robert , Andam Cheryl P. 
Published: May 2023

AbstractCoagulase-negative Staphylococcus (CoNS) are opportunistic pathogens implicated in many human and animal infections. The evolutionary history of CoNS remains obscure because of the historical lack of recognition for their clinical importance and poor taxonomic sampling. Here, we sequenced the genomes of 191 CoNS isolates representing 15 species sampled from diseased animals diagnosed in a veterinary diagnostic laboratory. We found that CoNS are important reservoirs of diverse phages, plasmids and mobilizable genes encoding antimicrobial resistance, heavy metal resistance, and virulence. Frequent exchange of DNA between certain donor-recipient partners suggests that specific lineages act as hubs of gene sharing. We also detected frequent recombination between CoNS regardless of their animal host species, indicating that ecological barriers to horizontal gene transfer can be surmounted in co-circulating lineages. Our findings reveal frequent but structured patterns of transfer that exist within and between CoNS species, which are driven by their overlapping ecology and geographical proximity.
Oxygen tolerance and detoxification mechanisms of highly enriched planktonic anaerobic ammonium-oxidizing (anammox) bacteria
Authors: Okabe Satoshi , Ye Shaoyu , Lan Xi , Nukada Keishi , Zhang Haozhe , Kobayashi Kanae , Oshiki Mamoru 
Published: May 2023

Abstract
Oxygen is a key regulatory factor of anaerobic ammonium oxidation (anammox). Although the inhibitory effect of oxygen is evident, a wide range of oxygen sensitivities of anammox bacteria have been reported so far, which makes it difficult to model the marine nitrogen loss and design anammox-based technologies. Here, oxygen tolerance and detoxification mechanisms of four genera of anammox bacteria; one marine species (“Ca. Scalindua sp.”) and four freshwater anammox species (“Ca. Brocadia sinica”, “Ca. Brocadia sapporoensis”, “Ca. Jettenia caeni”, and “Ca. Kuenenia stuttgartiensis”) were determined and then related to the activities of anti-oxidative enzymes. Highly enriched planktonic anammox cells were exposed to various levels of oxygen, and oxygen inhibition kinetics (50% inhibitory concentration (IC50) and upper O2 limits (DOmax) of anammox activity) were quantitatively determined. A marine anammox species, “Ca. Scalindua sp.”, exhibited much higher oxygen tolerance capability (IC50 = 18.0 µM and DOmax = 51.6 µM) than freshwater species (IC50 = 2.7–4.2 µM and DOmax = 10.9–26.6 µM). The upper DO limit of “Ca. Scalindua sp.” was much higher than the values reported so far (~20 µM). Furthermore, the oxygen inhibition was reversible even after exposed to ambient air for 12–24 h. The comparative genome analysis confirmed that all anammox species commonly possess the genes considered to function for reduction of O2, superoxide anion (O2•-), and H2O2. However, the superoxide reductase (Sor)-peroxidase dependent detoxification system alone may not be sufficient for cell survival under microaerobic conditions. Despite the fact that anaerobes normally possess no or little superoxide dismutase (Sod) or catalase (Cat), only Scalindua exhibited high Sod activity of 22.6 ± 1.9 U/mg-protein with moderate Cat activity of 1.6 ± 0.7 U/mg-protein, which was consistent with the genome sequence analysis. This Sod-Cat dependent detoxification system could be responsible for the higher O2 tolerance of Scalindua than other freshwater anammox species lacking the Sod activity.
A quixotic view of spatial bias in modelling the distribution of species and their diversity
Authors: Rocchini Duccio , Tordoni Enrico , Marchetto Elisa , Marcantonio Matteo , Barbosa A. Márcia , Bazzichetto Manuele , Beierkuhnlein Carl , Castelnuovo Elisa , Gatti Roberto Cazzolla , Chiarucci Alessandro , Chieffallo Ludovico , Da Re Daniele , Di Musciano Michele , Foody Giles M. , Gabor Lukas , Garzon-Lopez Carol X. , Guisan Antoine , Hattab Tarek , Hortal Joaquin , Kunin William E. , Jordán Ferenc , Lenoir Jonathan , Mirri Silvia , Moudrý Vítězslav , Naimi Babak , Nowosad Jakub , Sabatini Francesco Maria , Schweiger Andreas H. , Šímová Petra , Tessarolo Geiziane , Zannini Piero , Malavasi Marco 
Published: May 2023

AbstractEcological processes are often spatially and temporally structured, potentially leading to autocorrelation either in environmental variables or species distribution data. Because of that, spatially-biased in-situ samples or predictors might affect the outcomes of ecological models used to infer the geographic distribution of species and diversity. There is a vast heterogeneity of methods and approaches to assess and measure spatial bias; this paper aims at addressing the spatial component of data-driven biases in species distribution modelling, and to propose potential solutions to explicitly test and account for them. Our major goal is not to propose methods to remove spatial bias from the modelling procedure, which would be impossible without proper knowledge of all the processes generating it, but rather to propose alternatives to explore and handle it. In particular, we propose and describe three main strategies that may provide a fair account of spatial bias, namely: (i) how to represent spatial bias; (ii) how to simulate null models based on virtual species for testing biogeographical and species distribution hypotheses; and (iii) how to make use of spatial bias - in particular related to sampling effort - as a leverage instead of a hindrance in species distribution modelling. We link these strategies with good practice in accounting for spatial bias in species distribution modelling.
The impact of side chain elongation from the Y6 to Y6-12 acceptor in organic solar cells: a fundamental study from molecules to devices
Authors: Regnier Florian , Rillaerts Antoine , Lemaur Vincent , Viville Pascal , Cornil Jérôme 
Published: May 2023

This study is focused on the Y6 electron acceptor to assess the impact of elongating the inner side chain from 8 to 12 carbon atoms by combining DFT calculations, UV-visible spectroscopy, atomic force microscopy analysis and device characterization.
Improved energy storage performance of sandwich-structured P(VDF-HFP)-based nanocomposites by the addition of inorganic nanoparticles
Authors: Guo Yan , Zhou Di , Li Da , Zhao Weichen , Wang Yifei , Pang Lixia , Shi Zhongqi , Zhou Tao , Sun Shikuan , Singh Charanjeet , Trukhanov Sergei , Sombra Antonio Sergio Bezerra , Chen Guohua 
Published: May 2023

The sandwich-structured KNN-BZT/P(VDF-HFP) nanocomposites were prepared by solution casting method. When the breakdown strength reached 565 MV m−1, the excellent energy storage performance (Ud = 21.39 J cm−3, η = 70.54%) was obtained.
SHAMPOO: A stochastic model for tracking dust particles under the influence of non-local disk processes
Authors: Oosterloo M. , Kamp I. , van Westrenen W. , Dominik C. 
Published: May 2023

Context. The abundances of carbon, hydrogen, nitrogen, oxygen, and sulfur (CHNOS) are crucial for understanding the initial composition of planetesimals and, by extension, planets. At the onset of planet formation, large amounts of these elements are stored in ices on dust grains in planet-forming disks. The evolution of the ice in dust, however, is affected by disk processes, including dynamical transport, collisional growth and fragmentation, and the formation and sublimation of ice. These processes can be highly coupled and non-local.
Aims. In this work, we aim to constrain the disk regions where dynamical, collisional, and ice processing are fully coupled. Subsequently, we aim to develop a flexible modelling approach that is able to predict the effects of these processes acting simultaneously on the CHNOS budgets of planetesimal-forming material in these regions.
Methods. We compared the timescales associated with these disk processes to constrain the disk regions where such an approach is necessary, and subsequently developed the SHAMPOO (StocHAstic Monomer PrOcessOr) code, which tracks the CHNOS abundances in the ice mantle of a single ‘monomer’ dust particle of bare mass mm, embedded in a larger ‘home aggregate’. The monomer inside its home aggregate is affected by aerodynamic drag, turbulent stirring, collision processes, and ice adsorption and desorption simultaneously. The efficiency of adsorption onto and the photodesorption of the monomer here depends on the depth zm at which the monomer is embedded in the home aggregate. We used SHAMPOO to investigate the effect of thefragmentation velocity υfrag and home aggregate filling factor ϕ on the amount of CHNOS-bearing ices for monomers residing at r = 10 AU.
Results. The timescale analysis shows that the locations where disk processes are fully coupled depend on both grain size and ice species. We find that monomers released at 10 AU embedded in smaller, more fragile, aggregates with fragmentation velocities of 1 m s−1 are able to undergo adsorption and photodesorption more often than monomers in aggregates with fragmentation velocities of 5 and 10 m s−1. Furthermore, we find that at 10 AU in the midplane, aggregates with a filling factor of ϕ = 10−3 are able to accumulate ice 22 times faster on average than aggregates with ϕ = 1 under the same conditions.
Conclusions. Since different grain sizes are coupled through collisional processes and the grain ice mantle typically consists of multiple ice species, it is difficult to isolate the locations where disk processes are fully coupled, necessitating the development of the SHAMPOO code. Furthermore, the processing of ice may not be spatially limited to dust aggregate surfaces for either fragile or porous aggregates.
Intestinal MRI in Inflammatory Bowel Disease – Literature and Survey-Based Recommendations regarding Reporting by the German Radiological Society (DRG) and the German Competence Network for Inflammatory Bowel Diseases
Authors: Wessling Johannes , Kucharzik Torsten , Bettenworth Dominik , Luegering Andreas , Maaser Christian , Grenacher Lars , Juchems Markus S. , Ringe Kristina I. , Lauenstein Thomas , Schreyer Andreas G. 
Published: May 2023

Background MR-enterography/enteroclysis (MRE) is increasingly used for primary diagnosis, detection of complications, and monitoring of patients with inflammatory bowel disease (IBD). Standardization of reporting is relevant to ensure quality of the methodology and to improve communication between different faculties. The current manuscript describes the features that are required for optimized reporting of MRE in IBD.Methods An expert consensus panel of radiologists and gastroenterologists conducted a systematic search of the literature. In a Delphi process, members of the German Radiological Society (DRG) and members of the Competence Network for Inflammatory Bowel Diseases voted on relevant criteria for the reporting of findings in MRE. Based on the voting results, statements were developed by the expert consensus panel.Results Clinically relevant aspects of MRE findings have been defined to optimize reporting and to standardize terminology. Minimal requirements for standardized reporting are suggested. The statements focus on the description of disease activity as well as on complications of IBD. Attributes of intestinal inflammation are described and illustrated by exemplary images.Conclusion The current manuscript provides standardized parameters and gives practical recommendations on how to report and how to characterize MRE findings in patients with IBD.Key points: Citation Format
Comparison of suction techniques for EUS-guided tissue acquisition: Systematic review and network meta-analysis of randomized controlled trials
Authors: Giri Suprabhat , Afzalpurkar Shivaraj , Angadi Sumaswi , Marikanty Adarsh , Sundaram Sridhar 
Published: May 2023

Abstract
Background and study aims Despite the widespread use of
endoscopic ultrasound (EUS)-guided tissue acquisition, the choice of optimal suction technique
remains a subject of debate. Multiple studies have shown conflicting results with respect to
the four suction techniques: Dry suction (DS), no suction (NS), stylet slow-pull (SSP) and wet
suction (WS). Thus, the present network meta-analysis (NMA) was conducted to compare the
diagnostic yields of above suction techniques during EUS-guided tissue acquisition.
Methods A comprehensive literature search from 2010 to March 2022
was done for randomized trials comparing the aspirated sample and diagnostic outcome with
various suction techniques. Both pairwise and network meta-analyses were performed to analyze
the outcomes: sample adequacy, moderate to high cellularity, gross bloodiness and diagnostic
accuracy.
Results A total of 16 studies (n=2048 patients) were included in
the final NMA. WS was associated with a lower odd of gross bloodiness compared to DS (odds
ratio 0.50, 95% confidence interval 0.24–0.97). There was no significant difference between
the various suction methods with respect to sample adequacy, moderate to high cellularity and
diagnostic accuracy. On meta-regression, to adjust for the effect of needle type, WS was
comparable to DS in terms of bloodiness when adjusted for fine-needle aspiration needle.
Surface under the cumulative ranking analysis ranked WS as the best modality for all the
outcomes.
Conclusions The present NMA did not show superiority of any
specific suction technique for EUS-guided tissue sampling with regard to sample quality or
diagnostic accuracy, with low confidence in estimates.
Ultrasound Assisted Endoscopic Gastric Bypass (USA-EGB): a potential endoscopic alternative to surgical bypass, a pre-clinical proof of concept study
Authors: Kadkhodayan Kambiz , Viana Artur , Singh Sanmeet , Cosgrove Natalie , Jain Deepanshu , Yang Dennis , Arain Mustafa A , Irani Shayan , Hasan Muhammad Khalid 
Published: May 2023

Abstract
Background and study aims Endoscopic weight loss procedures have
gained traction as minimally invasive options for the primary treatment of obesity. Thus far,
we have developed endoscopic procedures that reliably address gastric restriction but result
in significantly less weight loss than surgical gastrointestinal bypass. The goal of this
nonsurvival study was to assess the technical feasibility of an endoscopic procedure, that
incorporates both gastric restriction and potentially reversible gastrointestinal
bypass.
Methods Ultrasound-assisted endoscopic gastric bypass (USA-EGB)
was performed in three consecutive live swine, followed by euthanasia and necropsy. Procedure
steps were: 1) balloon-assisted enteroscopy that determines the length of the bypassed limb;
2) endoscopic ultrasound-guided gastroenterostomy that creates a gastrointestinal anastomosis
using a lumen apposing metal stent; 3) endoscopic pyloric exclusion that disrupts transpyloric
continuity resulting in complete gastrointestinal bypass; and 4) gastric restriction that
reduces gastric volume.
Results Complete gastrointestinal bypass and gastric restriction
was achieved in all three swine. The mean total procedure time was 131 minutes (range
113–143), mean length of the bypassed limb was 92.5 cm and 180 cm, using short and long
overtubes, respectively. There were no significant complications.
Conclusions We successfully described USA-EGB in three
consecutive live swine. Further studies are needed to access the procedures safety, efficacy,
and clinical use.
Asymmetric Transfer Hydrogenation of Heterocyclic Compounds in Continuous Flow Using an Immobilized Chiral Phosphoric Acid as the Catalyst
Authors: Nagorny Pavel , Zhelavskyi Oleksii , Jhang Yin-Jia 
Published: May 2023

AbstractThis manuscript describes transfer hydrogenation of bicyclic nitrogen-containing heterocyclic compounds using the immobilized chiral phosphoric acid catalyst (R)-PS-AdTRIP in batch and continuous flow. A significant improvement in enantioselectivities is achieved in continuous flow with a fluidized bed reactor packed with (R)-PS-AdTRIP when the flow rate is increased from 0.2 mL/min to 2.0–2.5 mL/min. The optimized continuous flow conditions consistently provide 4–6% ee higher selectivity than transfer hydrogenation in batch with 2 mol% of (R)-PS-AdTRIP, and are used to generate multiple chiral products with the same fluidized bed reactor.
Using Existing Clinical Information Models for Dutch Quality Registries to Reuse Data and Follow COUMT Paradigm
Authors: Schepens Maike H. J. , Trompert Annemarie C. , van Hooff Miranda L. , van der Velde Erik , Kallewaard Marjon , Verberk-Jonkers Iris J. A. M. , Cense Huib A. , Somford Diederik M. , Repping Sjoerd , Tromp Selma C. , Wouters Michel W. J. M. 
Published: May 2023

Abstract
Background Reuse of health care data for various purposes, such as the care process, for quality measurement, research, and finance, will become increasingly important in the future; therefore, “Collect Once Use Many Times” (COUMT). Clinical information models (CIMs) can be used for content standardization. Data collection for national quality registries (NQRs) often requires manual data entry or batch processing. Preferably, NQRs collect required data by extracting data recorded during the health care process and stored in the electronic health record.
Objectives The first objective of this study was to analyze the level of coverage of data elements in NQRs with developed Dutch CIMs (DCIMs). The second objective was to analyze the most predominant DCIMs, both in terms of the coverage of data elements as well as in their prevalence across existing NQRs.
Methods For the first objective, a mapping method was used which consisted of six steps, ranging from a description of the clinical pathway to a detailed mapping of data elements. For the second objective, the total number of data elements that matched with a specific DCIM was counted and divided by the total number of evaluated data elements.
Results An average of 83.0% (standard deviation: 11.8%) of data elements in studied NQRs could be mapped to existing DCIMs . In total, 5 out of 100 DCIMs were needed to map 48.6% of the data elements.
Conclusion This study substantiates the potential of using existing DCIMs for data collection in Dutch NQRs and gives direction to further implementation of DCIMs. The developed method is applicable to other domains. For NQRs, implementation should start with the five DCIMs that are most prevalently used in the NQRs. Furthermore, a national agreement on the leading principle of COUMT for the use and implementation for DCIMs and (inter)national code lists is needed.
Screening and Management of Lynch Syndrome: The Chinese Experience
Authors: Yu Jiehai , Ding Pei-Rong , Jiang Wu 
Published: May 2023

AbstractLynch syndrome (LS), caused by germline mutations in the mismatch repair genes, is the most common hereditary colorectal cancer. While LS is also associated with various cancers, early detection of the proband is meaningful for tumor prevention, treatment, and familial management. It has been a dramatic shift on the screening approaches for LS. As the rapid development of the molecular biological methods, a comprehensive understanding of the LS screening strategies will help to improve the clinical care for this systematic disease. The current screening strategies have been well validated but mainly by evidence derived from western population, lacking consideration of the ethnic heterogeneity, which hampers the universality and clinical application in China. Hence, this review will focus on the Chinese experience in LS screening, aiming to help better understand the ethnic diversity and further optimize the screening strategies.
Profiling low-proficiency science students in the Philippines using machine learning
Authors: Bernardo Allan B. I. , Cordel Macario O. , Calleja Marissa Ortiz , Teves Jude Michael M. , Yap Sashmir A. , Chua Unisse C. 
Published: May 2023

AbstractFilipino students’ performance in global assessments of science literacy has always been low, and this was confirmed again in the PISA 2018, where Filipino learners’ average science literacy scores ranked second to last among 78 countries. In this study, machine learning approaches were used to analyze PISA data from the student questionnaire to test models that best identify the poorest-performing Filipino students. The goal was to explore factors that could help identify the students who are vulnerable to very low achievement in science and that could indicate possible targets for reform in science education in the Philippines. The random forest classifier model was found to be the most accurate and more precise, and Shapley Additive Explanations indicated 15 variables that were most important in identifying the low-proficiency science students. The variables related to metacognitive awareness of reading strategies, social experiences in school, aspirations and pride about achievements, and family/home factors, include parents’ characteristics and access to ICT with internet connections. The results of the factors highlight the importance of considering personal and contextual factors beyond the typical instructional and curricular factors that are the foci of science education reform in the Philippines, and some implications for programs and policies for science education reform are suggested.