bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological features of the incidence of cervical intraepithelial neoplasia in the modern megapolis
Authors: Sevostyanova O.  Yu. , Oboskalova T.  A. , Chumarnaya T.  V. , Rosyuk E.  A. , Belomestnov S.  R. , Sevostyanova N.  E. 
Published: June 2023

Background. Information on the incidence of cervical intraepithelial neoplasia (CIN) is relevant for planning and evaluating the effectiveness of medical care at the stage of secondary prevention of cervical cancer. Aim. To analyze the incidence of CIN and benign diseases of the cervix: erosion and ectropion, leukoplakia, polyp, according to medical organizations in Yekaterinburg in 2013–2019. Materials and methods. A descriptive epidemiological study of the incidence of cervical pathology in the population of women in Yekaterinburg in 2013–2019 was conducted. The forms of Federal Statistical Observation No. 12 “Information on the number of diseases registered in patients living in the service area of a medical organization”, in terms of erosion and ectropion, and data from the city’s women’s consultations on the number of cases of CIN, leukoplakia and cervical polyp were examined. Information on the number of female population of the city from Sverdlovskstat was used. Results. The primary incidence of CIN increased throughout the follow-up period. The indicator increased by 1.7 times compared to 2013 (p < 0.001) in 2016, it had a maximum value in 2019 – 215.5 per 100 thousand women and was 3.2 times more than in 2013 (p < 0.001). The dynamics of the primary incidence of other types of cervical pathology: ectropion, leukoplakia and cervical polyp, was characterized by the absence of significant changes (p > 0.05) in 2013–2019. The increase in the overall incidence of CIN was registered from 2014 to 2019 in comparison with 2013 (p < 0.001). The indicator of the overall incidence of CIN in 2019 was 2.1 times higher than in 2013 (p < 0.001). Conclusions. The growth of primary and total incidence of CIN in the population of Yekaterinburg women noted since the beginning of the XXI century continued in 2013–2019. The primary incidence rate of CIN had the maximum value in 2019. The increase in the incidence of CIN is associated with the natural spread of the disease, accessibility and improvement in the quality of medical care.
Population factors predicting survival in breast cancer: analysis according to the data of the Arkhangelsk Regional Cancer Registry in 2000–2020
Authors: Agaeva A. V. , Svetlakova A. V. , Gromov D. D. , Chemakina O. V. , Valkova L. E. , Dyachenko A. A. , Bogdanov D. V. , Valkov M. Yu. 
Published: June 2023

Background. Breast cancer (BC) is the leading cancer in the world and in Russia. Epidemiological factors predicting breast cancer survival in Russia have not been studied enough. Aim. To evaluate the factors predicting survival in BC by the data of the Arkhangelsk Regional Cancer Registry in 2000–2020 and the survival during the COVID-19 pandemic Materials and methods. Data on all cases of Вс for 2000–2020 retrieved from the Arkhangelsk Regional Cancer Registry database. Cancer-specific survival was estimated using the Kaplan–Meier and the life tables method. The prognostic value of variables available in Arkhangelsk Regional Cancer Registry was assessed in Cox regression. Results. The final analysis included 9,089 cases of breast cancer. During the observation period, 2723 deaths from breast cancer were registered. The one-, five- and ten-year survival rates in the entire population were 91.6 %, 73.0 % and 64.0 %, respectively. In a multivariate analysis, the risk of death from BC increased by 2.9, 8.2, 21.3 and 6.8 at 2, 3, 4 and unknown stages; 2.1 times with the localization of the tumor in the area of the nipple and areola; by 33 % in ductal cancer compared with lobular cancer, by 1.8 and 2.6 times in those who received palliative treatment and did not receive treatment; by 33 % in women aged 80 years and older; by 22 % for those living in rural areas. In the period 2013–2019, the 5-year cancer-specific survival reached 79.1 %, which is 14 % and 6 % higher than in the periods 2000–2006 and 2007–2012. Survival rates have not declined during the COVID-19 pandemic. Conclusion. The risk of death from BC is increased in advanced stages, ductal morphology, localization in the nipple-areolar region, age over 80 years, and living in rural areas. During the COVID-19 pandemic BC survival did not worsen, but this requires further study.
Analysis of the incidence of breast cancer in the Krasnoyarsk Territory
Authors: Zukov R. A. , Safontsev I. P. , Zyuzyukina A. V. , Permyakova K. D. , Zamay T. N. , Kichkaylo A. S. 
Published: June 2023

Aim. To conduct an analysis of the incidence of breast cancer in the Krasnoyarsk Territory for 2012–2021 and calculate the medium-term forecast of indicators until 2030. Materials and methods. An analysis of the incidence of breast cancer in the Krasnoyarsk Territory was performed using the Microsoft Office Excel 2021 program. A calculation was made of “rough” indicators of oncological incidence of breast cancer, calculated per 100,000 population of the corresponding sex and age. Forecasting the incidence of breast cancer was carried out among the population of residents of Krasnoyarsk and the Krasnoyarsk Territory (excluding the city of Krasnoyarsk), of the following type: y = b + ax, where y is the predicted incidence of lung cancer; х is the serial number of the year of observation, starting from the initial reference point (2012); b is a constant; a is a coefficient reflecting the average change in y with an increase in x by one unit; and the approximation coefficients R2 were also determined. Results and conclusion. The incidence of breast cancer during the study period increased both in the regions of the Krasnoyarsk Territory and in the city of Krasnoyarsk by 21.36 % and 19.05 %, respectively. Age-specific analysis of the incidence of breast cancer in the female population showed that the incidence in Krasnoyarsk in the age group of 20–24 years showed the maximum increase, the maximum decrease in incidence was observed in the age group of 25–29 years. In the regions of the Krasnoyarsk Territory, the maximum increase in this indicator is observed in the age group of 40–44 years, and the maximum decrease in the age group of 30–34 years. The share of early detection among the working-age population is higher in the regions of the Krasnoyarsk Territory and amounts to 4.7 % over a 10-year period. The share of early detection among the working-age population is higher in the regions of the Krasnoyarsk Territory and amounts to 4.7 % over a 10-year period. The proportion of early detection among women of the disabled population is higher in Krasnoyarsk, but there is a decrease of 0.97 %. According to prognostic estimates, by 2030 the incidence of breast cancer will increase by 1.2 times in the regions of the Krasnoyarsk Territory and in the city of Krasnoyarsk. The largest increase in the incidence is predicted in the female population of the city of Krasnoyarsk – by 1.24 times compared to 2021 and by 47.8 % compared to 2012. To overcome the growth, it is necessary to introduce new technologies and methods for early diagnosis and monitoring the effectiveness of anticancer therapy.
Ground-Motion Model for Hard-Rock Sites by Correction of Surface Recordings (Part 2): Correction, Mixed-Effects Regressions, and Results
Authors: Shible Hussein , Traversa Paola , Hollender Fabrice , Bard Pierre-Yves 
Published: June 2023

ABSTRACT
In the framework of site-specific seismic hazard assessment, the definition of reference motion is a crucial step. Reference motion is generally associated with hard-rock conditions, characterized by S-wave velocity exceeding 1500 m/s. However, ground motion recorded at sites with such conditions is poorly represented in existing strong-motion databases. Thus, the validity domains of most empirical ground-motion prediction equations (GMPEs) are not representative of reference rock conditions. To overcome this limitation and assess ground motion at reference conditions, the so-called “deconvolution approach” was proposed by Laurendeau et al. (2018) to correct surface recordings from theoretical 1DSH site response before GMPE developments. With the same purpose, in this article, we propose to apply the deconvolution approach using empirical site-response estimates as an alternative to theoretical ones. Using the Kiban–Kyoshin network (KiK-net) data, we estimate empirical site responses at KiK-net stations using generalized inversion techniques in addition to those from 1DSH numerical simulations, as presented in the companion article. Finally, a reference ground-motion model (RGMM) is determined based on empirically deconvolved ground motions. The advantage of using empirical rather than 1DSH site responses in the deconvolution approach is that in the former case the RGMM can be built based on records from an extensive set of sites, whereas the latter case is restricted to well-characterized sites with dominant 1D behavior. This makes the proposed approach easily exportable to different regions of the world, where precise site characterizations are not systematically available, and the knowledge of site behavior is limited.
Panpsychism and Pantheism. An Uneasy Alliance?
Authors: Jarocki Jacek 
Published: June 2023

Although panpsychism and pantheism were seen as natural allies in the past, in contemporary philosophy it is widely common to stress differences rather than similarities between them. As a result, only few panpsychists (e.g. so-called cosmopsychists) acknowledge that their view may imply pantheism. In my paper, I argue that at least some popular versions of panpsychism do lead to pantheism. My main argument is that panpsychism meets the minimal requirements for pantheism, defined as a view that the world is identical to all-encompassing Unity and that this Unity is divine. Although there are kinds of panpsychism that allow one to avoid these consequences, the most popular versions of this view pave the way to pantheism.
Many philosophers will find this a serious challenge for panpsychism. On the other hand, it can be argued that this conclusion is not as grim as it seems. An all-encompassing Cosmic Mind has little to do with the God of Abrahamic religions, so it does not necessarily deprive panpsychism of its naturalistic flavor that many find non-negotiable. Be that as it may, the aim of this paper is to turn the attention of proponents of panpsychism to yet another problem they need to solve.
Krytycyzm a polisemia, nieostrość i zależność kontekstowa
Authors: Odrowąż-Sypniewska Joanna 
Published: June 2023

W artykule zwracam uwagę na trudności jakie napotyka ktoś, kto chce wcielać w życie postulaty krytycyzmu dotyczące precyzji językowej. Zgodnie z tymi postulatami powinno się mówić jednoznacznie i precyzyjnie, a zatem unikać wyrażeń wieloznacznych, nieostrych i chwiejnych znaczeniowo. Jednakże postulaty te jest znacznie trudniej spełnić niż mogłoby się wydawać, bowiem istotne wątpliwości dotyczą samych zjawisk niejasności, nieostrości czy wieloznaczności. Wydaje się, że chcąc nauczyć innych unikania na przykład wypowiedzi wieloznacznych, powinniśmy dysponować adekwatną charakterystyką wieloznaczności i potrafić ją właściwie diagnozować. Tymczasem, sytuacja jest niesamowicie zagmatwana i w literaturze czy to filozoficznej, czy językoznawczej, nie ma jednej ustalonej definicji, czy choćby zgody co do tego, które wyrażenia są wieloznaczne. Nie ma także zgody co do tego, w jaki sposób charakteryzować polisemię i jak odróżniać ją np. od zależności kontekstowej. Wątpliwości budzi także charakterystyka nieostrości i właściwego klasyfikowania przypadków granicznych wyrażeń nieostrych. Nie ma natomiast wątpliwości, że większość wyrażeń języka naturalnego jest i nieostra, i zależna od kontekstu, i jednocześnie polisemiczna. Co więcej w wielu wypadkach te cechy wcale nie są defektami naszego języka, a wręcz usprawniają komunikację i umożliwiają nam szybkie przekazanie treści. Postulat unikania tego rodzaju wyrażeń jest po prostu nierealizowalny. Kierowanie się zasadami krytycyzmu pozwala jednak na łatwiejsze dostrzeżenie i unikanie wadliwości i uchybień wobec poprawności językowej w tych sytuacjach, gdy takie wadliwości utrudniają sprawną komunikację.
Integrating Plenitude, Axiarchism And Agency
Authors: Forrest Peter 
Published: June 2023

I consider three candidates for ultimate understanding: (1) ultimate agency, the familiar idea of understanding the existence and nature of the universe as created by God for good reasons; (2) axiarchism, the initially counter-intuitive idea that goodness is the first cause of contingent reality; and (3) plenitude, the thesis that all possible types of situation are real.
After some initial clarification, I note the problems with axiarchism, and offer solutions. These solutions require the unification of space and time as space-time, and the consequent introduction of what might be called hypertime, but which I take to be true time—Time with an upper case “T”. I note how axiarchism and plenitude may be combined into the Plenum Bonum thesis that all and only good universes are real. Next, I note some problems with agency as an ultimate way of understanding. Finally, I solve these by means of a theory of agency as completing axiarchism, the Good versus Good theory.
Analysis of the operating mode of the existing desorber and its modernization using additional contact devices
Authors:   Academy of Sciences of the Republic of Uzbekistan, Khurmamatov Abdugaffor M. , Auesbaev Alisher U. ,   Academy of Sciences of the Republic of Uzbekistan
Published: June 2023

Amine regeneration studies using two devices are presented in this work. In the first apparatus, a problem analysis was carried out in the operation of the desorber, which is used in petrochemical complexes, affecting various parameters of regeneration, such as temperature and pressure at the top and bottom of the column, pressure drop in the columns, rich amine feeding and flow rate, feed temperature, reboiler temperature and stripping pressure. The problems in the existing desorber and modernized the device was studied and an experiment that affects different parameters of regeneration was conducted. The desorber-1 (existing apparatus) and desorber-2 (modernized apparatus) mass-exchange apparatus was selected to serve as experimental regeneration plants. The dimensions of the experimental setup were determined based on the principles of geometric similarity with respect to the dimensions of an industrial regeneration column on a scale of 1:10 and physical similarity (with the same scaling) of gas and liquid flow rates and initial conditions. Thus, during the experiment, the pressure drop in the column increased in the desorber. To solve the problem and to improve the efficiency of the regeneration column, the desorber was upgraded using a Raschig packing. A laboratory stand was also developed for the purpose of conducting an experiment aimed at finding the optimal modes for the parameters of the regeneration column. As a result of the modernization of the desorber, the content of carbon dioxide in lean amine decreased, and there was a 4-fold reduction in column pressure drop. The modernization of the apparatus also led to an increase in the recovery factor.
EDUCAÇÃO TEATRAL E O USO DA COMUNICAÇÃO ALTERNATIVA
Authors: Santos Lucas Wendel Silva , Camargo Erica Daiane Ferreira , Givigi Rosana Carla dp Nascimento 
Published: June 2023

A linguagem teatral constitui um campo artístico de diferentes códigos e técnicas. O ensino de teatro é um grande desafio e quando se fala de Teatro de Animação, e no contexto da inclusão, percebe-se que há uma lacuna no conhecimento. Este trabalho tem como objetivo compreender como o teatro e os jogos teatrais podem contribuir para o desenvolvimento da comunicação da pessoa com autismo. Metodologicamente, foi utilizada a pesquisa-ação no contexto da arte-educação. Foi realizada de fevereiro de 2019 a outubro de 2020, semanalmente, integrando um total de 47 encontros, com dois meninos com autismo. Para a efetivação da pesquisa, os instrumentos foram a observação participante e a intervenção com jogos teatrais. Como resultados destacam-se: os bonecos, fantoches, dedoches, sombras e/ou objetos podem oportunizar a crianças com autismo novas formas de lidar com o mundo e a matéria concreta; é necessária a adaptação de abordagens, estratégias e métodos, para que o professor de teatro trabalhe com o aluno com deficiência; a Comunicação Alternativa Ampliada foi fundamental para o processo de interação e aprendizagem dos alunos com autismo; a construção de um protagonismo artístico das crianças com autismo; os corpos dessas crianças se revelaram como um dos veículos de comunicação e identidades. Conclui-se que é possível vincular o ensino de Teatro de Animação com a Comunicação Alternativa e Ampliada para o trabalho com crianças com autismo, promovendo a inclusão no universo da arte.
The optimal second-line therapy for older adults with type 2 diabetes mellitus: protocol for a systematic review and network meta-analysis using individual participant data (IPD)
Authors: Wang Jingya , Nirantharakumar Krishnarajah , Sainsbury Christopher , Moore David J , Sinclair Alan , Thomas G. Neil , Hanif Wasim , Singh Megha , Tan Luyuan , Wang Zhaonan , Simms-Williams Nikita , Yao Mi , Gunathilaka M.Niluka , Singh Pushpa , Toulis Konstantinos , Tsapas Apostolos , Coomar Dyuti , Price Malcolm James 
Published: June 2023

Abstract

Background
Due to increasing life expectancy, almost half of people with type 2 diabetes are aged 65 years or over worldwide. When metformin alone does not control blood sugar, the choice of next medication is not clear from currently available evidence. The existence of frailty and comorbidities in older adults further increases the complexity of medical decision-making. As only a relatively small proportion of trials report results separately for older adults, the relative efficacy and safety of second-line therapies in older adults with type 2 diabetes is unknown and requires further investigation. This individual participant data (IPD) network meta-analysis evaluates the relative efficacy and safety of second-line therapies on their own or in combination in older adults with type 2 diabetes mellitus.
Methods
Published and unpublished trials will be identified building on two previous comprehensive aggregate data network meta-analyses. Searches will be conducted in CENTRAL, MEDLINE, and EMBASE from 1st Jan 2015 onwards, and in clinical trials.gov from inception. Randomized controlled trials with at least 100 estimated older adults (≥ 65 years) receiving at least 24 weeks of intervention that assess the effects of glucose-lowering drugs on mortality, glycemia, vascular and other comorbidities outcomes, and quality of life will be eligible. The screening and data extraction process will be conducted independently by two researchers. The quality of studies will be assessed using the Cochrane risk of bias tool 2. Anonymised IPD of all eligible trials will be requested via clinical trial portals or by contacting the principal investigators or sponsors. Received data will be reanalysed where necessary to standardise outcome metrics. Network meta-analyses will be performed to determine the relative effectiveness of therapies.
Discussion
With the increasing number of older adults with type 2 diabetes worldwide, an IPD network meta-analysis involving data from all eligible trials would provide new insights into the optimal choices of second-line antidiabetic drugs to improve patient management and reduce unnecessary adverse events and the subsequent risk of comorbidities in older adults.
Systematic review registration
PROSPERO CRD42021272686
Extracellular vesicles from neural progenitor cells promote functional recovery after stroke in mice with pharmacological inhibition of neurogenesis
Authors: Campero-Romero Aura , Real Fernando , Santana-Martínez Ricardo , Molina-Villa Tonatiuh , Aranda Cristina , Ríos-Castro Emmanuel , Tovar-y-Romo Luis 
Published: June 2023

Abstract
Neural progenitor cells (NPCs) of the subventricular zone proliferate in response to ischemic stroke in the adult mouse brain. Newly generated cells have been considered to influence recovery following a stroke. However, the mechanism underlying such protection is a matter of active study since it has been thought that proliferating NPCs mediate their protective effects by secreting soluble factors that promote recovery rather than neuronal replacement in the ischemic penumbra. We tested the hypothesis that this mechanism is mediated by the secretion of multimolecular complexes in extracellular vesicles (EVs). We found that the molecular influence of oxygen and glucose-deprived (OGD) NPCs-derived EVs is very limited in improving overt neurological alterations caused by stroke compared to our recently reported astrocyte-derived EVs. However, when we inhibited the ischemia-triggered proliferation of NPCs with the chronic administration of the DNA synthesis inhibitor Ara-C, the effect of NPC-derived exosomes became evident, suggesting that the endogenous protection exerted by the proliferation of NPC is mainly carried out through a mechanism that involves the intercellular communication mediated by EVs. We analyzed the proteomic content of NPC-derived EVs cargo with label-free relative abundance mass spectrometry and identified several molecular mediators of neuronal recovery within these vesicles. Our findings indicate that NPC-derived EVs are protective against the ischemic cascade activated by stroke and, thus, hold significant therapeutic potential.