bluuebunny/crossref_metadata_2025_split huggingface dataset:
Twenty years of capacity building across the cancer prevention and control research network
Authors: Wangen Mary , Escoffery Cam , Fernandez Maria E. , Friedman Daniela B. , Hannon Peggy , Ko Linda K. , Maxwell Annette E. , Petagna Courtney , Risendal Betsy , Rohweder Catherine , Leeman Jennifer 
Published: April 2023

Abstract
Purpose
To improve population health, community members need capacity (i.e., knowledge, skills, and tools) to select and implement evidence-based interventions (EBIs) to fit the needs of their local settings. Since 2002, the Centers for Disease Control and Prevention has funded the national Cancer Prevention and Control Research Network (CPCRN) to accelerate the implementation of cancer prevention and control EBIs in communities. The CPCRN has developed multiple strategies to build community members’ capacity to implement EBIs. This paper describes the history of CPCRN’s experience developing and lessons learned through the use of five capacity-building strategies: (1) mini-grant programs, (2) training, (3) online tools, (4) evidence academies, and (5) evaluation support for partners’ capacity-building initiatives.

Methods
We conducted a narrative review of peer-reviewed publications and grey literature reports on CPCRN capacity-building activities. Guided by the Interactive Systems Framework, we developed histories, case studies, and lessons learned for each strategy. Lessons were organized into themes.

Results
Three themes emerged: the importance of (1) community-engagement prior to and during implementation of capacity-building strategies, (2) establishing and sustaining partnerships, and (3) co-learning at the levels of centers, networks, and beyond.

Conclusion
CPCRN activities have increased the ability of community organizations to compete for external funds to support implementation, increased the use of evidence in real-world settings, and promoted the broad-scale implementation of cancer control interventions across more than eight states. Lessons from this narrative review highlight the value of long-term thematic networks and provide useful guidance to other research networks and future capacity-building efforts.
Historical cultivars of Allium cepa L. (Aggregatum-Group) introduced to Sweden 1830–1860
Authors: De Vahl Erik 
Published: April 2023

AbstractThis study presents the plant material of A. cepa L. Aggregatum-Group introduced and spread in Sweden between 1830 and 1860. The plant material exemplifies different principles regarding the denominations and shows the range of cultons available in the north of Europe by the time, but also examples of domestic local cultivars. It is essential to deepen the knowledge of the plant material and the name use connected to cultons spread in the nineteenth century. Historical records of old growing systems and propagation methods add valuable insights of the preservation values tied to the genetic diversity of the gene pool for future breeding. Differing practices and principles for distinguishing between potato onions, shallots and onions in European countries have sometimes made it difficult to understand historical records. The results of this study shows that shallot and potato onions, later mainly vegetatively propagated, were already in the nineteenth century occasionally propagated and spread by true seed in Europe. In addition, a Russian growing system with a true seed generation was found in literature. The article concludes that knowledge of older cultivation systems and introduction history deepens the link between the cultural-historical and the biological conservation values of plant material in long time preservation. Gene bank accessions may not only be valuable in breeding but also utilized and preserved as part of a biological or green heritage.
National or local infodemic? The demand for news in Italy during COVID-19
Authors: Castriota Stefano , Delmastro Marco , Tonin Mirco 
Published: April 2023

AbstractInformation can have an important impact on health behavior and, according to the World Health Organization, an ‘infodemic’ has accompanied the current pandemic. Observing TV news viewership in Italy during the COVID-19 pandemic using actual consumption data, we investigate whether demand for national and local news depends on national or local epidemiological developments, as measured by the number of new positives or the number of current positives on any given day. Exploiting the fact that the impact of the pandemic displays a great deal of variation among the different regions, we find that at the regional level, demand for both national and local news responds to national epidemiological developments rather than to local ones. This has implications regarding the incentives for local politicians to take preventive action.
Microglia polarization in nociplastic pain: mechanisms and perspectives
Authors: Atta Ahd A. , Ibrahim Weam W. , Mohamed Ahmed F. , Abdelkader Noha F. 
Published: April 2023

AbstractNociplastic pain is the third classification of pain as described by the International Association for the Study of Pain (IASP), in addition to the neuropathic and nociceptive pain classes. The main pathophysiological mechanism for developing nociplastic pain is central sensitization (CS) in which pain amplification and hypersensitivity occur. Fibromyalgia is the prototypical nociplastic pain disorder, characterized by allodynia and hyperalgesia. Much scientific data suggest that classical activation of microglia in the spinal cord mediates neuroinflammation which plays an essential role in developing CS. In this review article, we discuss the impact of microglia activation and M1/M2 polarization on developing neuroinflammation and nociplastic pain, besides the molecular mechanisms engaged in this process. In addition, we mention the impact of microglial modulators on M1/M2 microglial polarization that offers a novel therapeutic alternative for the management of nociplastic pain disorders.
Graphical abstract
Illustrating the mechanisms underlying microglia activation in central sensitization and nociplastic pain. LPS lipopolysaccharide, TNF-α tumor necrosis factor-α, INF-γ Interferon gamma, ATP adenosine triphosphate, 49 P2Y12/13R purinergic P2Y 12/13 receptor, P2X4/7R purinergic P2X 4/7 receptor, SP Substance P, NK-1R Neurokinin 1 receptor, CCL2 CC motif ligand 2, CCR2 CC motif ligand 2 receptor, CSF-1 colony-stimulating factor 1, CSF-1R colony-stimulating factor 1 receptor, CX3CL1 CX3C motif ligand 1, CX3XR1 CX3C motif ligand 1 receptor, TLR toll-like receptor, MAPK mitogen-activated protein kinases, JNK jun N-terminal kinase, ERK extracellular signal-regulated kinase, iNOS Inducible nitric oxide synthase, IL-1β interleukin-1β, IL-6 interleukin-6, BDNF brain-derived neurotrophic factor, GABA γ-Aminobutyric acid, GABAR γ-Aminobutyric acid receptor, NMDAR N-methyl-D-aspartate receptor, AMPAR α-amino-3-hydroxy-5-methyl-4-isoxazolepropi-onic acid receptor, IL-4 interleukin-4, IL-13 interleukin-13, IL-10 interleukin-10, Arg-1 Arginase 1, FGF fibroblast growth factor, GDNF glial cell-derived neurotrophic factor, IGF-1 insulin-like growth factor-1, NGF nerve growth factor, CD Cluster of differentiation.
Saved by seaweeds (II): Traditional knowledge, home remedies, medicine, surgery, and pharmacopoeia
Authors: Pérez-Lloréns J. L. , Critchley A. T. , Cornish M. L. , Mouritsen O. G. 
Published: April 2023

AbstractHumankind has known the benefits of seaweeds since time immemorial. A number of these applications were likely passed down in the oral histories particularly of coastal dwellers and those using different seaweeds as food and treatments for common ailments. The beneficial use of many types of seaweeds was reported and recorded into some of the first written medical texts. The common benefits of these seaweed concoctions and applications seems to be linked to the presence of hydrocolloids and the various bioactive compounds. We believe this collation brings together, for the first time to our knowledge, a number of excerpts from major medical publications and esteemed writers of the day. It provides a rich background supporting the positive applications of various seaweeds to a multitude of human ailments, from skin to bowel, inside and out and many of the places in between!
MULTIPLIERS OF THE TRIGONOMETRIC SYSTEM
Authors: Kazarian K. S. 
Published: April 2023

AbstractWe study the system $$\begin{aligned} \{\overline{L(t)}e^{i nt}\}_{n=-\infty }^{-1} \cup \{ M(t) e^{i nt}\}_{n=0}^{\infty }, \end{aligned}$$

{

L
(
t
)

¯

e

int

}

n
=
-
∞

-
1

∪

{
M

(
t
)

e

int

}

n
=
0

∞

,

where L and M are boundary values of some outer functions defined in the unit disc. Necessary and sufficient conditions on functions L and M are found so that the system is a Schauder basis in $$L^{p}(\mathbb {T}),$$

L
p

(
T
)

,

$$1< p < \infty$$

1
<
p
<
∞

.
A redundantly actuated 2-DOF 3RRR PKM with flexure joints: less is more
Authors: Berendsen Dustin , Sridhar Aditya , Aarts Ronald 
Published: April 2023

AbstractThe development of a planar manipulator with flexure joints and redundant actuation has been considered before, showing that the redundancy can be exploited to increase the support stiffness and to reduce static actuator loads. In this previous design the manipulator’s workspace has been defined to encompass all kinematically accessible end effector positions. In the current paper we reconsider the design philosophy. It will be shown that limiting the workspace (“less”) ultimately results in a better performance in a larger area (“more”).The dynamic performance of the manipulator is evaluated with a flexible multibody model. The links can safely be considered as rigid parts, but the model has to account for the nonlinear stiffness behaviour of the flexure joints undergoing relatively large deflections. The nonlinear spatial flexible beam elements implemented in the spacar software result in numerically efficient models that have proven to be well-suited for design optimisation. With such a flexible multibody model, the geometry of the manipulator is optimised to maximise the workspace area while assuring a minimal parasitic natural frequency and limiting the local stresses throughout the full workspace. Furthermore, the simulations show that preloading of the flexure joints results in reduced actuator torques that are needed to counteract the finite joint compliance for stationary positioning anywhere except for the equilibrium position of the end effector.The optimised design has been build and validated experimentally. A control system that handles the actuator redundancy by minimising the 2-norm of the driving torques has been synthesised. It is demonstrated that the setup’s behaviour is similar to the model and that in particular the preloading significantly lowers the required actuator torques.
Aspergillus Species Causing Invasive Fungal Disease in Queensland, Australia
Authors: Stewart Adam G. , Isler Burcu , Simos Peter , Farquhar Drew , George Narelle , Golmayo Mila , Heney Claire 
Published: April 2023

Abstract
Background
Aspergillus species are important causes of invasive fungal disease, particularly among those with an impaired immune system. Increasing reports have revealed a rising incidence of antifungal drug resistance among Aspergillus spp., particularly among cryptic species. Understanding local antifungal susceptibility patterns is paramount to delivering optimal clinical care.

Methods
Aspergillus spp. recovered from clinical specimens between 2000 and 2021 from Pathology Queensland were collected. Aspergillus spp. were identified routinely morphologically, and where there was ambiguity or a lack of sporulation, by sequencing of the internal transcribed spacer (ITS) region. All Aspergillus spp. that underwent antifungal susceptibility testing according to the CLSI M38-A3 method and were recorded and included in the study. Amphotericin B, voriconazole, posaconazole, isavuconazole, micafungin, caspofungin, and anidulafungin were tested. Pathology Queensland services all public healthcare facilities in Queensland, Australia.

Results
236 Aspergillus spp. were identified from clinical specimens during the study period. The most frequent species identified were Aspergillus section Fumigati (n = 119), Aspergillus section Flavi (n = 35), Aspergillus terreus (n = 32) and Aspergillus niger (n = 29). Overall, MIC50/90 values for voriconazole, posaconazole, itraconazole, and isavuconazole were 0.25/1, 0.25/0.5, 0.25/0.5, and 0.5/2 mg/L respectively. Echinocandins demonstrated low MIC values overall with micafungin and anidulafungin both having an MIC50/90 of 0.015/0.03 mg/L. A total of 15 cryptic species were identified; high triazole MIC values were observed with a voriconazole MIC50/90 of 2/8 mg/L. From 2017 to 2021 we observed an increase in incidence of isolates with high voriconazole MIC values. There was no difference in voriconazole MIC values between Aspergillus spp. acquired in North Queensland when compared to Southeast Queensland, Australia.

Conclusion
Increasing reports of antifungal resistance among Aspergillus spp. is concerning and warrants further investigation both locally and worldwide. Active surveillance of both the emergence of different Aspergillus spp. and changes in antifungal susceptibility patterns over time is crucial to informing clinicians and treatment guidelines.
Phoenix dactylifera in vitro culture and transformation of Thio-60 antifungal gene via chitosan nanoparticle
Authors: Allah Kholoud Wagih Abd , Alabasey Ezz El Din Gadalla Hussein , Ahmed Kasem Zaki , Hussien Eman Tawfik , Razik Ashraf Bakry Abdel 
Published: April 2023

AbstractThe date palm, or Phoenix dactylifera L., is one of the world’s oldest fruit trees. The entire date palm tree is used to produce a variety of goods, including food, clothing, fibre, and shelter. Tissue culture is one of the most recent methods used to multiply date palms and produce disease-free offspring. Plant tissue culture technology has advantages over conventional methods of propagation for the quick and extensive multiplication of significant plants in vitro, regardless of the season, and disease-free. This is because it preserves space and time. For this study, three different cultivars were used (Barhy, Sakkoti, and Shamia). For the three cultivars, ¾ MS medium supplemented with 1 mg/L indole butyric acid IBA and 0.25 mg/l activated charcoal (AC) provided the optimal in vitro culture conditions. Plant gene function research and cultivar development are now both possible thanks to the advancement of plant transformation technologies. Date palm plants were given the AT1G12660 “Thio-60” gene to make them resistant to fungus infection. Utilizing chitosan nanoparticles for genetic transformation, the gene was introduced into three cultivars of dates (Barhy, Sakkoti, and Shamia). Run a conventional PCR to verify genetic fusion into all three cultivars. The fungal infection with Fusarium oxysporum was used to determine the resistance of the transgenic cultivar lines after it was established that the thionin gene had been transferred into transgenic date palm cultivars. Date crop transgenic lines showed strong resistance and a decline in the percentage of fungal infection-induced inhibition.
Item analysis of G8 screening in uro-oncologic geriatric patients
Authors: Bouzan J. , Nellas S. , Stoilkov B. , Willschrei P. , Horstmann M. 
Published: April 2023

Abstract
Introduction/background
The G8 score is a widespread screening tool for geriatric frailty in oncology. The aim of this study was to evaluate the scores and relevance of G8 items in a standard screening of geriatric patients with uro-oncologic diseases to better understand the results of the assessment.

Methods
Eighty-two consecutive uro-oncologic geriatric patients aged 75 years and older were evaluated. All patients underwent a G8 screening that consisted of 8 items. Patients with a G8 score above 14 were considered geriatric “fit”, while others were considered to be “frail”. Overall results and single item scores were evaluated. Clinical data were gathered from patients’ charts.

Results
The mean age of the patients was 82 years (min. 75–max. 102). In 36 of the patients, the G8 score indicated “no-frailty”, and in 46 patients, the G8 score indicated “frailty”. The mean G8 score was 12.9 (min 4–max 17 pts). Item analysis revealed that points were most often lost in items H (polypharmacy), P (comparison of health status to peers) and Age. Fifty-nine, 56 and 52 patients lost points on item Age, item H and item P, respectively. In contrast, the majority of patients reached the maximum score for nutritional items [i.e., items A (food intake), B (weight loss) and F (body mass index (BMI))]. For item A, 73 patients reached the maximum score; for item B, 62 patients reached the maximum score; and for item F, 72 patients reached the maximum score. There were no differences in this distribution pattern when comparing tumour entities, sex, and patients with local vs. metastatic disease.

Conclusion
The present study revealed a high percentage of suspicious test results. Potential reasons for these findings include the low threshold of the G8 overall score and the fact that in some items, points were easily lost. Modifications of the test should be considered.
The P2X7 receptor in mucosal adaptive immunity
Authors: Grassi Fabio , Marino Rebecca 
Published: April 2023

AbstractThe P2X7 receptor (P2X7R) is a widely distributed cation channel activated by extracellular ATP (eATP) with exclusive peculiarities with respect to other P2XRs. In recent years, P2X7R has been shown to regulate the adaptive immune response by conditioning T cell signaling and activation as well as polarization, lineage stability, cell death, and function in tissues. Here we revise experimental observations in this field, with a focus on adaptive immunity at mucosal sites, particularly in the gut, where eATP is hypothesized to act in the reciprocal conditioning of the host immune system and commensal microbiota to promote mutualism. The importance of P2X7R activity in the intestine is consistent with the transcriptional upregulation of P2xr7 gene by retinoic acid, a metabolite playing a key role in mucosal immunity. We emphasize the function of the eATP/P2X7R axis in controlling T follicular helper (Tfh) cell in the gut-associated lymphoid tissue (GALT) and, consequently, T-dependent secretory IgA (SIgA), with a focus on high-affinity SIgA-mediated protection from enteropathogens and shaping of a beneficial microbiota for the host.
Occlusion-robust scene flow-based tissue deformation recovery incorporating a mesh optimization model
Authors: Chen Jiahe , Hara Kazuaki , Kobayashi Etsuko , Sakuma Ichiro , Tomii Naoki 
Published: April 2023

Abstract
Purpose
Tissue deformation recovery is to reconstruct the change in shape and surface strain caused by tool-tissue interaction or respiration, which is essential for providing motion and shape information that benefits the improvement of the safety of minimally invasive surgery. The binocular vision-based approach is a practical candidate for deformation recovery as no extra devices are required. However, previous methods suffer from limitations such as the reliance on biomechanical priors and the vulnerability to the occlusion caused by surgical instruments. To address the issues, we propose a deformation recovery method incorporating mesh structures and scene flow.

Methods
The method can be divided into three modules. The first one is the implementation of the two-step scene flow generation module to extract the 3D motion from the binocular sequence. Second, we propose a strain-based filtering method to denoise the original scene flow. Third, a mesh optimization model is proposed that strengthens the robustness to occlusion by employing contextual connectivity.

Results
In a phantom and an in vivo experiment, the feasibility of the method in recovering surface deformation in the presence of tool-induced occlusion was demonstrated. Surface reconstruction accuracy was quantitatively evaluated by comparing the recovered mesh surface with the 3D scanned model in the phantom experiment. Results show that the overall error is 0.70 ± 0.55 mm.

Conclusion
The method has been demonstrated to be capable of continuously recovering surface deformation using mesh representation with robustness to the occlusion caused by surgical forceps and promises to be suitable for the application in actual surgery.
Pyrene-naphthalimide Schiff base as a fluorescent pigment in water-based security ink
Authors: Bhagya R. S. , Muthamma Kashmitha , Sunil Dhanya , Shetty Prakasha , Kulkarni Suresh D. 
Published: April 2023

AbstractFluorescence-based materials that are affordable and easy to use for commercial anti-counterfeiting applications are in high demand. While exploring new fluorescent pigments, a pyrene-naphthalimide Schiff base, 5-hydroxy-2-((pyren-1-ylmethylene)amino)-1H-benzo[de]isoquinoline-1,3(2H)-dione (NHPY) with yellow fluorescence under UV light was synthesized. An eco-friendly flexographic ink prepared with NHPY as the pigment was coated on a UV dull paper and further printed on security paper as well as packaging papers and boards. When exposed to UV light, the printed samples showed yellow fluorescence. The light fastness, gloss, colorimetric results, and abrasion resistance of the printed samples proved that NHPY is a suitable fluorescent pigment for security printing applications.
Robotic transaxillary thyroidectomy: time to expand indications?
Authors: Rossi Leonardo , De Palma Andrea , Fregoli Lorenzo , Papini Piermarco , Ambrosini Carlo Enrico , Becucci Chiara , Gjeloshi Benard , Morganti Riccardo , Marco Puccini , Materazzi Gabriele 
Published: April 2023

AbstractIn 2016, the American Thyroid Association published a statement on remote-access thyroid surgery claiming that it should be reserved to patients with thyroid nodule ≤ 3 cm, thyroid lobe < 6 cm and without thyroiditis. We retrospectively enrolled all patients who underwent robotic transaxillary thyroidectomy between February 2012 and March 2022. We compared surgical outcomes between patients who presented a thyroid gland with a nodule ≤ 3 cm, thyroid lobe < 6 cm and without thyroiditis (Group A) and patients without these features (Group B). The rate of overall complications resulted comparable (p = 0.399), as well as the operative time (p = 0.477) and the hospital stay (p = 0.305). Moreover, bleeding resulted associated to thyroid nodule > 3 cm (p = 0.015), although all bleedings but one occurred in the remote-access site from the axilla to the neck. In experienced hands, robotic transaxillary thyroidectomy is feasible and safe even in patients with large thyroid nodules or thyroiditis.