bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating -omics approaches into population-based studies of endocrine disrupting chemicals: a scoping review
Authors: Maitre Léa , Jedynak Paulina , Gallego Marta , Ciaran Laura , Audouze Karine , Casas Maribel , Vrijheid Martine 
Published: December 2022

Abstract
Health effects of endocrine disrupting chemicals (EDCs) are challenging to detect in the general population. Omics technologies become increasingly common to identify early biological changes before the apparition of clinical symptoms, to explore toxic mechanisms and to increase biological plausibility of epidemiological associations. This scoping review systematically summarises the application of omics in epidemiological studies assessing EDCs-associated biological effects to identify potential gaps and priorities for future research. Ninety-eight human studies (2004–2021) were identified through database searches (PubMed, Scopus) and citation chaining and focused on phthalates (34 studies), phenols (19) and PFASs (17), while PAHs (12) and recently-used pesticides (3) were less studied. The sample sizes ranged from 10 to 12,476 (median = 159), involving non-pregnant adults (38), pregnant women (11), children/adolescents (15) or both populations studied together (23). Several studies included occupational workers (10) and/or highly exposed groups (11) focusing on PAHs, PFASs and pesticides, while studies on phenols and phthalates were performed in the general population only. Analysed omics layers included metabolic profiles (30, including 14 targeted analyses), miRNA (13), gene expression (11), DNA methylation (8), microbiome (5) and proteins (3). Twenty-one studies implemented targeted multi-assays focusing on clinical routine blood lipid traits, oxidative stress or hormones. Overall, DNA methylation and gene expression associations with EDCs did not overlap across studies, while some EDC-associated metabolite groups, such as carnitines, nucleotides and amino acids in untargeted metabolomic studies, and oxidative stress markers through targeted studies were consistent across studies. Studies had common limitations such as small sample sizes, cross-sectional designs and single sampling for exposure biomonitoring. In conclusion, there is a growing body of evidence evaluating the early biological responses to exposure to EDCs. This review points to a need for larger longitudinal studies, wider coverage of exposures and biomarkers, replication studies and standardisation of research methods and reporting.
Pemodelan Desain Modular Hunian Sementara Berbasis Lokalitas Material di Desa Hargotirto, Kecamatan Kokap, Kabupaten Kulon Progo
Authors: Christian Ivan , Feriadi Henry 
Published: December 2022

Title: Modeling Temporary Shelter Modular Design Based on Material Locality in Hargotirto Village, Kokap District, Kulon Progo Regency

Hargotirto village has an area that is prone to landslides. Several times the landslides caused the affected communities to be forced to flee to temporary shelters with several problems, such as the absence of private space for refugees and the lack of supporting facilities. The modular temporary shelter model developed through this research is expected to create advantages in terms of provision, time, and quality. The modeled temporary housing also considers local elements such as local building architecture, craftsman skills, and local materials obtained from local raw materials. Material locality data were collected through field observation surveys and guided interviews with residents and builders. The research method used is simulation and modeling research through modeling the form of temporary housing that considers the use of local materials such as wood and bamboo, the strength of modular construction, and variations in space requirements. To check the structural strength and construction details of each developed model using SAP2000 software. Several alternative models have been developed, taking into account the availability of local materials, the condition of the land area, and a series of modules in the form of single or row shelters that provide shared space for refugees.
Institutional and policy process for climate-smart agriculture: evidence from Nagaland State, India
Authors: Patra Nirmal K. , Babu Suresh Chandra 
Published: December 2022

Abstract
A critical global policy question is how the environmental management interventions could be repurposed to meet the sustainable development goals and their target for food security, climate protection, and environmental sustainability. A common challenge facing food systems in developing countries is to improve agricultural productivity to ensure food security for all without increasing the emission of greenhouse gases (GHGs) from agriculture. Climate-smart agriculture (CSA) approaches help to reduce GHG emissions from agriculture and address the challenges of climate change (CC) and food insecurity. Yet, CSA lack understanding of the institutional arrangements and policy processes. This paper examines 38 aspects to assess the institutional and policy status for CC mitigation and adaptation and CSA in Nagaland, India. Furthermore, we use these aspects to develop a scale to measure the policy and institutional environment for mitigation and adaptation of CC and implementation of CSA. Nagaland is relatively in a better position in nine aspects, although it can improve. Methodologically, the scale developed in this paper and the identified factors can help study the institutional and policy status of a country, state, or region. We identify several implications for understanding CC and CSA institutions and policies for informing policy research and practice.
La COVID-19 continua entre nosotros: no bajemos la guardia
Authors: Matta Solis Eduardo Percy 
Published: December 2022

El mundo continúa lidiando con sucesivas oleadas de la enfermedad por COVID-19, impulsadas por la aparición de variantes virales. Debemos reforzar los cuidados en las personas mayores y vulnerables. El nivel de gravedad está relacionado con la edad y la presencia de comorbilidades que hacen más vulnerable la condición de salud de las personas. Se resalta papel vital de la vacunación para prevenir enfermedades potencialmente mortales y mejorar la salud mundial. Las personas que padecen de enfermedades de evolución crónica, deben vacunarse, ya que ello reduce el riesgo de un mayor deterioro de la salud y muerte. Todavía hay un porcentaje importante de la población que no quieren vacunarse o dudan en hacerlo, para ello es importante hacer esfuerzos para contrarrestar la vacilación de la población.
Finalmente señalar que la pandemia de COVID-19 ha afectado significativamente a las personas para que se desvíen de los comportamientos de estilo de vida normales. Dentro de los impactos negativos, tenemos una mayor incidencia de sobrepeso u obesidad, y la limitación de las interacciones humanas con consecuencias psicológicas. Los profesionales de la salud tienen aún desafíos que enfrentar.
Mitral Valve Prolapse and Sudden Cardiac Death in Athletes at High Risk
Authors: Vriz Olga , Landi Irene , Eltayeb Abdalla , Limongelli Giuseppe , Mos Lucio , Delise Pietro , Bossone Eduardo , D`Andrea Antonello 
Published: December 2022

Abstract:
Mitral valve prolapse (MVP) is the most frequent valvulopathy in the general population,
with usually a favourable prognosis. Although it can be associated with some complications,
ventricular arrhythmias (VA) and sudden cardiac death (SCD) are the most worrying. The estimated
risk of SCD in MVP is between 0.2% to 1.9% per year, including MVP patients with and without
severe mitral regurgitation (MR). The association between SCD and MVP is expressed by a
phenotype called “malignant MVP” characterized by transthoracic echocardiography (TTE) findings
such as bileaflet myxomatous prolapse and mitral annulus disjunction (MAD), ECG findings
such as repolarization abnormalities, complex ventricular arrhythmias (c-VAs) and LV fibrosis of
papillary muscles (PMs) and inferobasal wall visualized by late gadolinium enhancement cardiac
magnetic resonance (LGE-CMR). Therefore, attention is raised for patients with “arrhythmic
MVP” characterized from an ECG point of view by frequent premature ventricular contractions
(PVCs) arising from one or both PMs as well as by T-wave inversion in the inferolateral leads. In
athletes, SCD is the most frequent medical cause of death and in young subjects (< 35 years) usually
is due to electrical mechanism affecting who has a silent cardiovascular disease and are not considered
per se a cause of increased mortality. In MVP, SCD was reported to happen during sports
activity or immediately after and valve prolapse was the only pathological aspect detected.
The aim of the present paper is to explore the association between SCD and MVP in athletes, focusing
attention on ECG, TTE in particular, and CMR findings that could help to identify subjects
at high risk for complex arrhythmias and eventually SCD. In addition, it is also examined if sports
activity might predispose patients with MVP to develop major arrhythmias.
Sulphur Containing Heterocyclic Compounds as Anticancer Agents
Authors: Sharma Vikas , Kaur Balwinder , Singh Gurdeep , Singh Iqubal 
Published: December 2022

Abstract:
After cardiovascular disease, cancer is the most common cause of death worldwide. Due to their versatility,
heterocyclic compounds play an important role in drug discovery. Medical remedies are constantly being discovered,
especially for catastrophic disorders such as cancer. Here, this review is focused on sulphur containing heterocyclic
compounds as anticancer agents. Sulphur is found in a variety of vitamin cofactors, sugars, and nucleic acids, and it
also plays a function in controlling translation by sulphurating transfer RNA. Sulphur has obtained a lot of interest in
the anticancer research medicinal fields. Thiophene derivatives were tested for anti-proliferative activity against breast
cancer cells in a recent screening study, and the bulk of chemicals exhibited potent inhibitory effects. In recent years,
azoles such as thiazole and thiadiazole structures have gained prominence in cancer research.
Signal Assessment Using ML for Evaluation of WSN Framework in
Greenhouse Monitoring
Authors: Kochhar Aarti , Kumar Naresh , Arora Utkarsh 
Published: December 2022

Background and Objective:
The deployment of a Wireless Sensor Network (WSN) provides a useful aid for monitoring greenhouse-like environments. WSN helps in achieving precision agriculture i.e. more yield can be produced with precise inputs. Before the deployment of a sensor network, it is necessary to explore the communication range of nodes. Communication signals are affected by losses due to stems, fruits, twigs, leaves, infrastructure material, etc. in a greenhouse. So as part of the deployment strategy, signal assessment is required in the greenhouse.

Methods:
This research work proposes a Machine Learning (ML) based signal assessment for the evaluation of WSN deployment in different structures of a tomato greenhouse. Signal strength is measured for a naturally ventilated greenhouse and a fan-pad ventilated greenhouse. Measurements for the naturally ventilated greenhouse are considered with two case scenarios i.e. with transmitter and receiver in the same lane and with transmitter and receiver in different lanes. Models are developed for measured values and evaluated in terms of correlation and error between measured and model formulated values.

Results and Conclusion:
For the naturally ventilated greenhouse case scenario 1, correlation increases from 91.83% to 95.42% as the degree increases from 2 to 7. Correlation for naturally ventilated greenhouse case scenario 2 rises from 72.51% at degree 2 to 90.09% at degree 10. For the fan-pad ventilated greenhouse, the model has a more complex fitting because of the spatial variability within the greenhouse. Correlation of the model increases from 79.39% to 84.06 % with an increase in degree from 2 to 11. For the naturally ventilated greenhouse, better correlation is achieved at lower degrees compared to the fan-pad ventilated greenhouse.
Examining Homophily, Language Coordination, and Analytical Thinking in Web-Based Conversations About Vaccines on Reddit: Study Using Deep Neural Network Language Models and Computer-Assisted Conversational Analyses
Authors: Li Yue , Gee William , Jin Kun , Bond Robert 
Published: December 2022

Background
Vaccine hesitancy has been deemed one of the top 10 threats to global health. Antivaccine information on social media is a major barrier to addressing vaccine hesitancy. Understanding how vaccine proponents and opponents interact with each other on social media may help address vaccine hesitancy.

Objective
We aimed to examine conversations between vaccine proponents and opponents on Reddit to understand whether homophily in web-based conversations impedes opinion exchange, whether people are able to accommodate their languages to each other in web-based conversations, and whether engaging with opposing viewpoints stimulates higher levels of analytical thinking.

Methods
We analyzed large-scale conversational text data about human vaccines on Reddit from 2016 to 2018. Using deep neural network language models and computer-assisted conversational analyses, we obtained each Redditor’s stance on vaccines, each post’s stance on vaccines, each Redditor’s language coordination score, and each post or comment’s analytical thinking score. We then performed chi-square tests, 2-tailed t tests, and multilevel modeling to test 3 questions of interest.

Results
The results show that both provaccine and antivaccine Redditors are more likely to selectively respond to Redditors who indicate similar views on vaccines (P<.001). When Redditors interact with others who hold opposing views on vaccines, both provaccine and antivaccine Redditors accommodate their language to out-group members (provaccine Redditors: P=.044; antivaccine Redditors: P=.047) and show no difference in analytical thinking compared with interacting with congruent views (P=.63), suggesting that Redditors do not engage in motivated reasoning. Antivaccine Redditors, on average, showed higher analytical thinking in their posts and comments than provaccine Redditors (P<.001).

Conclusions
This study shows that although vaccine proponents and opponents selectively communicate with their in-group members on Reddit, they accommodate their language and do not engage in motivated reasoning when communicating with out-group members. These findings may have implications for the design of provaccine campaigns on social media.
Pelayanan Kesehatan Ibu: Perspektif Ibu Hamil Yang Terkonfirmasi COVID-19 Di Kabupaten Sleman
Authors: Nisa Iztihadun , Choiriyyah Ifta , Marthias Tiara , Padmawati Retna Siwi 
Published: December 2022

Latar Belakang: Pandemi COVID-19 dapat berdampak pada status kesehatan wanita hamil serta pada pelayanan kesehatan. Selama pandemi COVID-19, terjadi penurunan kualitas pelayanan kesehatan ibu. Peningkatan kualitas layanan kesehatan dapat dilakukan dengan mempertimbangkan perspektif pengguna layanan untuk meningkatkan kompetensipenyedia layanan, serta mengetahui harapan dari pengguna layanan kesehatan terhadap pelayanan kesehatan yang diberikan.Tujuan: melihat apakah pelayanan kesehatan ibu dengan berdasarkan pedoman dan standar sudah sesuai dengankebutuhan ibu untuk pelayanan kesehatan maternal. Metode: Penelitian ini merupakan penelitian kualitatif dengan pendekatan fenomenologi untuk mengeksplorasi bagaimana pengalaman ibu hamil yang pernah terkonfirmasi COVID-19 dalam pemanfaatan layanan kesehatannya. Penelitian ini akan dilaksanakan di Kabupaten Sleman, Daerah IstimewaYogyakarta setelah mendapatkan ethical clearance dari Komisi Etik. Hasil: Pandemi COVID-19 keseluruhan berdampak secara biologis, psikologis, maupun sosial terhadap wanita hamil. Sebagian besar pelayanan kesehatan maternal di masa pandemi belum berjalan secara optimal baik dari segi pelayanan yang berfokus pada pasien, waktu tunggu, serta belum optimalnya pengadaan pelayanan psikologis kesehatan untuk ibu hamil dengan COVID-19 maupun untuk ibu hamil dalam kondisi normal. Harapan ibu hamil untuk pelayanan kesehatan yaitu adanya peningkatan fasilitas kesehatan untuk ibu hamil dengan COVID-19, adanya penguatan pengawasan, pemantauan, dan peningkatan rasa empati petugas kesehatan, serta adanya layanan psikologis untuk ibu hamil secara umum. Kesimpulan: Selama pandemi COVID-19, layanan kesehatan dapat memenuhi kebutuhan perawatan secara biologis namun belum mampu untuk memenuhi kebutuhan perawatan psikologis dan sosial. Diperlukan peningkatan respon dan empati dari petugas kesehatan dan peningkatan pelayanan kesehatan yang lebih berfokus pada kebutuhan menyeluruh wanita hamil.

Kata Kunci: Ibu Hamil, Coronavirus Disease (COVID-19), High Quality Health System, Pelayanan Kesehatan Ibu dimasa pandemic COVID-19
Korelasi Disparitas Ketersediaan Tenaga Medis Gigi Antardaerah Terhadap Pemanfaatan Layanan Gigi dan Mulut di Indonesia
Authors: Sinaga Alzeressy Putri Irnadya 
Published: December 2022

Latar Belakang: Prevalensi masalah gigi mulut yang tinggi di Indonesia tidak diikuti dengan pemanfaatan layanan gigi mulut yang adekuat. Salah satu penyebab utamanya yaitu kurangnya tenaga medis gigi dan adanya disparitas terhadap distribusi tenaga medis gigi, yang juga menyebabkan ketidaksetaraan geografis dan sosial ekonomi dalam pemanfaatan layanan gigi mulut di Indonesia. Tujuan: Mengukur hubungan pemanfaatan layanan kesehatan gigi mulut dengan ketersediaan tenaga medis gigi serta mengkaji faktor-faktor lainnya yang berhubungan dengan ketidaksetaraan geografis dalam pemanfaatan layanan gigi mulut di Indonesia. Metode: Penelitian cross-sectional menggunakan Data Sampel BPJS Kesehatan 2017-2018 dan data rutin Kementerian Kesehatan tahun 2017. Dataset terdiri dari diagnosis primer dan klaim pelayanan kesehatan gigi rujukan tingkat Rumah Sakit yang mencakup 2.580 peserta BPJS Kesehatan. Faktor yang berhubungan dengan pemanfaatan pelayanan kesehatan gigi mulut berdasarkan jumlah diagnosis dan besaran klaim dianalisis menggunakan model regresi linear multivariat. Hasil: Terdapat disparitas yang signifikan dalam pemanfaatan layanan gigi mulut antardaerah di Indonesia. Ketersediaan dokter gigi (umum dan spesialis) memiliki korelasi positif dengan jumlah diagnosis dan klaim. Ketersediaan dokter gigi memiliki korelasi positif dengan jumlah diagnosis (0.30, 95% CI: 0.28-0.32) dan besaran penggantian biaya klaim (Rp 565.909, 95% CI: 89.425-1.042.385). Ketersediaan dokter gigi spesialis menunjukkan korelasi tertinggi terhadap jumlah diagnosis (0.54, 95% CI: 0.53-0.55) dan besaran penggantian biaya klaim (Rp 1.194.741, 95% CI: 662.468-1.727.014). Kesimpulan: Disparitas ketersediaan tenaga medis gigi dapat berkontribusi terhadap ketidaksetaraan pemanfaatan layanan gigi dan besaran penggantian biaya klaim yang dibayarkan oleh BPJS Kesehatan untuk pelayanan kesehatan gigi mulut antardaerah di Indonesia.
Kata Kunci: Tenaga Medis Gigi; Ketidaksetaraan Geografis; Indonesia; Jaminan Kesehatan Nasional; Pemanfaatan Layanan Gigi Mulut
In vitro enamel surface roughness analysis of 4 methods for removal of remaining orthodontic adhesive after bracket debonding
Authors: Thys Daniela Greenhalgh , Martins Fabiola Roberta Pizzolatti , Cardinal Lucas , Ribeiro Gerson Luiz Ulema 
Published: December 2022

ABSTRACT

Objectives
To perform an in vitro qualitative and quantitative evaluation of the enamel surface (by scanning electronic microscopy [SEM] and measuring polishing time and roughness analysis, respectively) among four methods to remove remaining orthodontic adhesive after bracket debonding.

Materials and Methods
Forty-one human premolars were randomly divided into four groups (n = 10) according to the adhesive remnant removal method and one tooth was used as control: Group 1 (G1): Enhance (Dentsply, Milford, USA); Group 2 (G2): Fiberglass (TDV, Pomerode, Brazil); Group 3 (G3): DU10CA-Ortho (Dian Fong Industrial, Shenzhen, China); Group 4 (G4): Sof-Lex Pop-On (3M ESPE, Seefeld, Germany). Roughness was measured before bonding and after complete removal of the remaining adhesive (Ra2). SEM analysis was performed on one sample of each group after adhesive removal and polishing. The time required for adhesive remnant removal and polishing was measured in all groups. Analysis of variance and Tukey post hoc for pairwise comparison was applied to compare polishing times among groups and analysis of covariance was used to compare Ra2 means.

Results
Comparison between groups show that G4 presented the lowest Ra2 mean (0.43 μm)c followed by G3 (0.71 μm)ac, G1 (1.06 μm)ab, and G2 (1.21 μm)b - different letters, statistically different at P ≤ 0.05. In addition, Fiberglass was more time-consuming for adhesive remnant removal than other methods (P ≤ .05). SEM analysis showed that some enamel damage occurred for all methods.

Conclusions
All methods were able to remove the remaining adhesive and polish the enamel. The DU10CA-Ortho and Sof-Lex methods promoted better polishing of the enamel surface and exhibited a similar time-consuming process.
In Becoming. Instability of Psychedelic Substances
Authors: Sadowska Zuzanna 
Published: December 2022

Psychoactive substances are subject to law control, imposed through the system of medical prescription or legal prohibition, with legal penalties for their unauthorized use. The consumption of drugs in a non-medical contexts is often labelled as "drug abuse", and the substance used in this way as a “narcotic” - the term endowed with illegality (Goodman et al. 2017). While legal, medical and popular discourses attempt to establish the distinction between what is an illicit drug and what is a medicine by creating the presumptive ontologies of drugs, this way of approaching substances has become the object of critique within drug research associated with the ‘ontological turn’. Scholars in this field of study have destabilised the assumption of a fixed, ready-made, singular drug objects, postulating thinking about substance use as a mutable system of relations intertwined in the broader assemblages and ecologies of drug use.
In this article, by using ethnographic examples and through the analysis of research conducted within the so called “psychedelic turn” movement, I demonstrate the fluidity and multiplicity of psychoactive substances and examine diverse ways in which the dominant – Euro-American – drug categorizations are undermined. I pose the question of how the border between what is an “illicit drug” and what is a “medicine” is stabilized and destabilized through the embodied users’ practices and scientific discourses.
Micro-regional variants of the flint knapping traditions in the Late Neolithic from the perspective of Prokopiak's Mount
Authors: Domańska Lucyna 
Published: December 2022

The distinctive sandy structure of Prokopiak’s Mount in Opatowice stands out from the surrounding black soils of the Kujawy Upland, and therefore attracted the interest among the Late Neolithic communities of the region. A program of comprehensive archaeological research was conducted here in 1985-1998, eleven sites were investigated and the materials obtained from five of them were published. These sites all produced rich flint assemblages.Three of these assemblages, being relatively homogeneous, (Opatowice 33, 36 and 42), were selected for research on the formation of local traditions of flint production in the Late Neolithic in Kujawy. The presented assemblages cover the entire chronological span from3650 BC to 2600 BC. And chronologically correspond to the classic Wiórek horizon (Opatowice 33), the Luboń-Radziejów horizon (Opatowice 42) and the classic GAC horizon (Opatowice 36).