bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adsorptive removal of phosphorus from aqueous solutions using natural and modified coal solid wastes
Authors: Hosseinpour Somayeh , Hejazi-Mehrizi Majid , Hashemipour Hassan , Farpoor Mohammad Hady 
Published: March 2023

Abstract
An invaluable utilization approach for industrial wastes is to employ them as effective adsorbents for environmental pollutants. This study aimed to investigate the phosphorus (P) adsorption behavior of coal wastes and zeolite in three forms of pristine powder (CP and ZP), nanoparticles (CNP and ZNP), and Fe (III)-modified nanoparticles (MCNP and MZNP). The adsorbents were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR), scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS) analyses. The effects of pH, initial P concentration, and contact time were studied under batch mode. Results showed an optimum pH range of 2–6 for the P adsorption process. The pseudo-second-order kinetic model and the Langmuir isotherm described the P adsorption data well. The P adsorption capacity of the studied adsorbents was enhanced after modifications. However, the coal-based modified adsorbents represented higher P adsorption performances rather than the zeolite ones. The maximum P adsorption capacity (Qmax) values were obtained as 0.36, 3.23, and 30.48 mg g−1 for CP, CNP, and MCNP, and 0.80, 2.84, and 6.99 mg g−1 for ZP, ZNP, and MZNP, respectively. The surface complexation, ligand exchange, and electrostatic attraction processes were identified as the main P adsorption mechanisms by the studied adsorbents.
The Effect of Statins on the Differentiation and Function of Central
Nervous System Cells
Authors: Chamani Sajjad , Mobasheri Leila , Zerehpoosh Shadi , Naghizadeh Ali , McCloskey Alice P. , Rizzo Manfredi , Jamialahmadi Tannaz , Sahebkar Amirhossein 
Published: March 2023

Abstract:
Statins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) reduce plasma
cholesterol and improve endothelium-dependent vasodilation, inflammation, and oxidative
stress. The effect of statins on the central nervous system (CNS), particularly on cognition
and neurological disorders such as cerebral ischemic stroke, multiple sclerosis (MS),
and Alzheimer’s disease (AD), has received increasing attention in recent years, both
within the scientific community and in the media. This review aims to provide an updated
discussion on the effects of statins on the differentiation and function of various nervous
system cells, including neurons and glial cells. Additionally, the mechanisms of action
and how different types of statins enter the CNS will be discussed.
Structure-based Virtual Screening, Molecular Docking, Molecular
Dynamics Simulation, and Metabolic Reactivity Studies of
Quinazoline Derivatives for their Anti-EGFR Activity Against
Tumor Angiogenesis
Authors: Shah Altaf Ahmad , Ahmad Shaban , Yadav Manoj Kumar , Raza Khalid , Kamal Mohammad Amjad , Akhtar Salman 
Published: March 2023

Background:
Epidermal growth factor receptor (EGFR/HER-1) and its role in tumor development
and progression through the mechanism of tumor angiogenesis is prevalent in non-small lung cancer,
head and neck cancer, cholangiocarcinoma & glioblastoma. Previous treatments targeting the oncogenic
activity of EGFR's kinase domain have been hindered by acquired mutational resistance and side
effects from existing drugs like erlotinib, highlighting the need for new EGFR inhibitors through structure-
based drug designing.

Objective:
The research aims to develop novel quinazoline derivatives through structure-based virtual
screening, molecular docking, and molecular dynamics simulation to potentially interact with EGFR's kinase
domain and impede tumor angiogenic phenomenon.

Methods:
Quinazoline derivatives were retrieved and filtered from the PubChem database using structure-
based virtual screening and the Lipinski rule of five drug-likeness studies. Molecular docking-based
virtual screening methods and molecular dynamics simulation were then carried out to identify top leads.

Results:
A total of 1000 quinazoline derivatives were retrieved, with 671 compounds possessing druglike
properties after applying Lipinski filters. Further filtration using ADME and toxicity filters yielded
28 compounds with good pharmacokinetic profiles. Docking-based virtual screening identified seven
compounds with better binding scores than the control drug, dacomitinib. After cross-checking binding
scores, three top compounds QU524, QU571, and QU297 were selected for molecular dynamics simulation
study of 100 ns interval using Desmond module of Schrodinger maestro to understand their conformational
stability.

Conclusion:
The research results showed that the selected quinazoline leads exhibited better binding
affinity and conformational stability than the control drug, erlotinib. These compounds also had good
pharmacokinetic and pharmacodynamic profiles and did not violate Lipinski’s rule of five limits. The
findings suggest that these leads have the potential to target EGFR's kinase domain and inhibit the
EGFR-associated phenomenon of tumor angiogenesis.
β-sitosterol Protects against Aluminium Chloride-mediated Neurotoxicity
Authors: Banerjee Sugato , Yadav Sanjay , Aggarwal Punita , Khan Faiz , Khodve Gopal , Padhy Dibya Sundar , Yadav Poonam 
Published: March 2023

Objective:
The objective of this study is to investigate the neuroprotective effects of β-
sitosterol using the AlCl3 model of Alzheimer's Disease.

Methods:
AlCl3 model was used to study cognition decline and behavioral impairments in C57BL/6
mice. Animals were randomly assigned into 4 groups with the following treatments: Group 1 received
normal saline for 21 days, Group 2 received AlCl3 (10 mg/kg) for 14 days; Group 3 received AlCl3(10
mg/kg) for 14 days + β-sitosterol (25mg/kg) for 21 days; while Group 4 was administered β-sitosterol
(25mg/kg) for 21 days. On day 22, we performed the behavioral studies using a Y maze, passive
avoidance test, and novel object recognition test for all groups. Then the mice were sacrificed. The
corticohippocampal region of the brain was isolated for acetylcholinesterase (AChE), acetylcholine
(ACh), and GSH estimation. We conducted histopathological studies using Congo red staining to
measure β-amyloid deposition in the cortex and hippocampal region for all animal groups.

Results:
AlCl3 successfully induced cognitive decline in mice following a 14-day induction period, as
shown by significantly decreased (p < 0.001) in step-through latency, % alterations, and preference
index values. These animals also exhibited a substantial decrease in ACh (p <0.001) and GSH (p <
0.001) and a rise in AChE (p < 0.001) compared to the control group. Mice administered with AlCl3
and β-sitosterol showed significantly higher step-through latency time, % alteration time, and % preference
index (p < 0.001) and higher levels of ACh, GSH, and lower levels of AChE in comparison to
the AlCl3 model. AlCl3-administered animals also showed higher β-amyloid deposition, which got
significantly reduced in the β-sitosterol treated group.

Conclusion:
AlCl3 was effectively employed to induce a cognitive deficit in mice, resulting in neurochemical
changes and cognitive decline. β-sitosterol treatment mitigated AlCl3-mediated cognitive
impairment.
Current Trends in Feature Extraction and Classification Methodologies of
Biomedical Signals
Authors: Kumar Sachin , Veer Karan , Kumar Sanjeev 
Published: March 2023

Abstract:
Biomedical signal and image processing is the study of the dynamic behavior of various bio-signals, which benefits academics and research. Signal processing is used to assess the behavior of analogue and digital signals for the assessment, reconfiguration, improved efficiency, extraction of features, and reorganization of patterns. This paper unveils hidden characteristic information about input signals using feature extraction methods. The main feature extraction methods used in signal processing are based on studying time, frequency, and frequency domain. Feature exaction methods are used for data reduction, comparison, and reducing dimensions, producing the original signal with sufficient accuracy with a structure of an efficient and robust pattern for the classifier system. Therefore, an attempt has been made to study the various feature extraction methods, feature transformation methods, classifiers, and datasets for biomedical signals.
The Herbal Treatment of Osteoarthritis
Authors: Verma Vikrant 
Published: March 2023

Abstract:
Osteoarthritis is widely acknowledged as the most common, devastating, and diverse
ailment that wreaks havoc on people's lives across the world. In the elderly, it is estimated that 10%
of males and 18% of women over the age of 60 are affected and its frequency and incidence are increasing
in the present scenario. Herbal medicines appear to be safe and effective with antiosteoarthritic
effects that help in increased alleviation of symptoms and/or impairment and consist
of numerous phytochemicals that have been scientifically verified and confirmed with antiosteoarthritic
activity. Currently, there is no definitive cure for osteoarthritis, and there are no effective
therapies that can stop or halt the progression of the disease. However, there are a variety of
therapies available, ranging from new to old. Intra-articular injections, topical treatments, and oral
medicines are altogether FDA-approved replacements for surgery. These all modes of treatment
may prove fatal sometimes and are not always successful. Herbal medicines have been utilized
worldwide for the treatment of osteoarthritis. This review mainly focuses on the treatment approach
of osteoarthritis with the herbal medicines available, because of the side effects and toxicities, and
unwanted symptoms of the present treatments.
Relación entre el clima organizacional y la competencia docente en escuelas municipales de Talca
Authors: Rojas Oscar , Ortega Francisca , Espinosa Mauricio , Campbell Lucas 
Published: March 2023

En la gran mayoría de las organizaciones existe una armonía en el trabajo que es observado y ejercido por todos sus miembros, aspecto que abarca en el concebir y reaccionar de los empleados frente a los acontecimientos que se suscitan, por ello la relevancia de avivar el clima organizacional, donde el líder debe saber hacia dónde puede dirigir y equilibrar los propósitos institucionales. La presente investigación tiene como objetivo general analizar la relación entre el clima organizacional y el docente competitivo de las Escuelas Municipales de Talca, para ello se enmarcó en una investigación básica, no experimental, transeccional, correlacional, descriptiva, la muestra de 58 docentes, la recolección de datos a través de la encuesta y como instrumento, cuestionario con escalamiento Likert. La investigación reveló que existe una relación directa y significativa entre clima organizacional y docente competitivo con un valor de 0.817, también se debe destacar el rechazo de la hipótesis nula, debido a que el valor de significancia es < 0.05 aceptando que las variables tienen relación entre sí, concluyendo que toda institución educativa que desarrolla un clima organizacional excelente basado en la iniciativa, compromiso y la actuación del personal docente logrará alcanzar la competitividad en las praxis educativa.
PENGARUH INTENSITAS MODAL, PERTUMBUHAN PENJUALAN DAN UKURAN PERUSAHAAN TERHADAP PENGHINDARAN PAJAK
Authors: Marta Desviya , Nofryanti Nofryanti 
Published: March 2023

This study aims to determine the effect of capital intensity, sales growth and company size on tax avoidance in healthcare companies listed on the indonesia stock exchange. This type of research is type of quantitative research. The data used in this study is secondary from the indonesia stock exchange for the period 2016-2020. The number of samples in this study were 8 companies with an observation period of 5 years so that the number of research samples is 40.. The technic used in this research is purposive sampling. The data in this study used panel data regression analysis using the Eviews 12 application. Based on the results of panel data regression analysis, it show that capital intensity have no effect on tax avoidance, sales growth and company size an effect on tax avoidance.
The Effects of Job Insecurity on Turnover Intention of Stars Hotel Employee in DKI Jakarta: Mediating Role of Job Stress
Authors: Putri Widya A. , Ariyanto Eny 
Published: March 2023

The hotel industry is in a state of perpetual change due to the emergence of covid-19, high competition, and the economic crisis. Based on that situation, this research study discusses the effects of Job Insecurity and Job Stress on Turnover Intention and also the mediating role of Job Stress. A total of 150 surveys were conducted in stars hotel in DKI Jakarta by adapting non-probability sample using purposive sampling technique. This research study was used the Structural Equation Model and processed with Structural Positive and Equation Model (SEM) Partial Least Square (Smart PLS) software to test the hypotheses in a mediation model with the bootstrapping method. The result presents that job insecurity was insignificant toward turnover intention while job stress was positive and significant toward turnover intention, job insecurity was positive and significant toward job stress, and mediating relationship was also confirmed.
Indonesia's Presidential Threshold As Open Legal Policy In Election: As A Base For Muslim Studies
Authors: Anggar Putra  
Published: March 2023

Since its inception in the 2004 general election until the simultaneous general election in 2019, the use of standardization of presidential and vice presidential nominations, also known as the presidential threshold system, has garnered numerous benefits and drawbacks. Thus far, the writers have established that the presidential threshold system is an open legal policy (open legal policy) that does not violate the Republic of Indonesia's constitution or is constitutional. The purpose of this article is to examine the presidential threshold's compliance with an open legal policy from the standpoint of Islamic law. The research employs a legal-normative as well as a theological or syar'i approach. The study's findings indicate that the presidential threshold was established in conformity with open legal policy principles strengthened by Constitutional Court Decision 14/PUU-XI/2013. The presidential threshold system is one of the measures to strengthen the presidential system and simplify political parties, thereby enhancing long-term governance and promoting the legislative and executive institutions' professionalism in their performance. According to siyasa syariyyah, one must be a descendant of the Quraysh tribe in order to apply as a state or imamate leader. However, this requirement is not absolute; if one has been permitted to become a leader, one does not have to be a descendant of the Quraysh tribe in order to eliminate the sense of ashabiyah. Meanwhile, the presidential threshold system ensures full uniformity in order to allow for the nomination of candidates for state leaders (president and vice president).
Keywords: Open Legal Policy; Presidential Thresholds; General election
Adherence of uropathogenic Escherichia coli in dog urine after consumption of food supplemented with cranberry (Vaccinium macrocarpon)
Authors: Carvajal-Campos Amaranta , Jeusette Isabelle , Mayot Gilles , Torre Celina , André Agnès , Di Martino Patrick 
Published: March 2023

Abstract

Introduction

Escherichia coli is the most common pathogen isolated from the urine of dogs with urinary tract infections (UTIs). While there are many studies in humans investigating the potential for the prevention of UTIs by dietary consumption of cranberry, few analogous studies have been carried out in dogs.

Material and Methods
Eight dogs, four male and four female, were successively fed two diets, first a control without cranberry, and then the second diet containing cranberry extracts. Naturally excreted urine was collected on the tenth day after the start of each diet for 24 h and used for bacterial growth. Madin-Darby canine kidney cell adherence by the uropathogenic E. coli G1473 strain expressing type 1 pili and positive for P pili and haemolysin gene markers was quantified after growth in urine samples.

Results
Significant reductions in bacterial adherence to MDCK cells (from −16.5 to −73.4%, P < 0.05) were observed in the four females but not in the males after consumption of the cranberry extracts compared to the same animals consuming the control diet.

Conclusion
Dietary supplementation with cranberry may provide some degree of protection to female dogs against adhesion of uropathogenic E. coli to urinary epithelial cells.
Identification of Altered Transcripts and Pathways in Triple Negative Breast Cancer
Authors: Kuzņecova Elza , Daneberga Zanda , Berga-Švītiņa Egija , Nakazawa-Miklaševiča Miki , Irmejs Arvīds , Gardovskis Jānis , Miklaševičs Edvīns 
Published: March 2023

Abstract
Triple negative breast cancer (TNBC) is a breast cancer subtype characterised by lack of oestrogen receptor, progesterone receptor, and human epidermal growth factor receptor, and by worse prognosis than other cancer types. The aim of this study was to identify hub genes and molecular pathways for possible prognostic markers for TNBC. Nineteen breast cancer transcriptomes were sequenced using Illumina platform and analysed to identify differentially expressed genes in the TNBC subtype. Gene ontology enrichment analysis was conducted using the ToppGene tool. Then, the STRING online database was used for protein-protein interaction (PPI) network construction. Cytohubba and the MCODE plug-in were used to screen functional modules and hub genes. In total, 229 DEGs were identified by differential gene expression analysis in the TNBC group. Eight genes were screened out from the PPI network — FOXA1, ESR1, TFF1, GATA3, TFF3, AR, SLC39A6, COL9A1. In conclusion, this study indicates that the molecular subtype specific gene expression pattern provides useful information for targeted, biomarker-driven treatment options.
Association Between 25(OH)D Levels and Primary Arterial Hypertension
Authors: Požarskis Anatolijs , Požarska Rita , Baranovska Ļubova 
Published: March 2023

Abstract
This study seeks to determine whether patients from a family physician’s practice have an association between 25(OH)D levels and primary arterial hypertension (AH). The study included a total of 1068 patients who were tested for vitamin D status. Data from their outpatient medical records were analysed: sex, age, body mass index, glomerular filtration rate, and the history of AH. Primary arterial hypertension was diagnosed in 63% of the patients. The mean vitamin D level in the study population was 25 ng/ml, and the largest group, or 36%, was found to have vitamin D deficiency (20–29 ng/ml). Odds ratio (OR) for hypertension was not inversely correlated with higher vitamin D levels. No statistically significant increase was observed in OR in a multi-factor analysis. The relevant hypertension ORs were 1.8 (0.4–7.5), 1.1 (0.3–4.5), 1.7 (0.4–7.2) and 0.7 (0.1–4.8) 30 ng/ml to 45 ng/ml, 20 to 29 ng/ml, 10 to 19 ng/ml, and < 10 ng/ml compared to the group of ³ 45 ng/ml. No association was found between 25(OH)D levels and the primary arterial hypertension in study participants.
Histopatologi Hati Tikus Wistar Periodontitis Apikalis Kronis Pasca Pemberian Medikamen Intrakanal
Authors: Ene Theresia , Merdana I Made , Winaya Ida Bagus Oka , Widiadnyani Ni Kadek Eka , Sudimartini Luh Made 
Published: March 2023

Penyakit periodontal merupakan salah satu masalah kesehatan gigi dan mulut yang mempunyai prevalensi sebanyak 96,58% di Indonesia. Penggunaan obat kimia yang dapat menimbulkan efek samping kepada pasien, menyebabkan masyarakat mulai alternatif pengobatan lain dengan memanfaatkan bahan alam yaitu meniran (Phyllanthus niruri L). Penelitian ini mengkaji mengenai histopatologi hati tikus wistar periodontitis apikalis kronis pasca pemberian medikamen intrakanal. Penelitian ini menggunakan 48 ekor tikus wistar jantan dibagi menjadi 4 kelompok perlakuan dengan lama waktu aplikasi pasta medikamen yaitu hari ke-7, 14 dan ke-21. Hewan coba dikondisikan mengalami periodontitis apikal kronis dengan induksi bakteri E. faecalis kedalam gigi selama 21 hari. Pada hari ke-22 semua kelompok perlakuan medikamen dibuka GICnya dan diberikan perlakuan medikamen yang ditetapkan, setelah ditutup kembali dengan menggunakan GIC. Variabel yang diamati adalah adanya infiltarsi sel radang, kongesti dan nekrosis. Data dianalisis menggunakan uji statistik non-parametrik Kruskal-Wallis dan bila menunjukan perbedaan nyata maka dilanjutkan dengan uji Mann-Whitney. Hasil pengamatan pada infiltarsi sel radang dan kongesti menunjukkan bahwa tidak terdapat perbedaan yang nyata (P>0,05) pada perlakuan P1, P2 dan P3 serta terdapat perbedaan nyata pada P0 (P<0,05). Namun hasil analisis statistik pengamatan nekrosis pada histopatologi hati menunjukan tidak terdapat perbedaan nyata (P>0,05) pada perlakuan P0, P1, P2 dan P3. Dari hasil penelitian dapat disimpulkan bahwa pemberian ekstrak etanol daun meniran hijau pada tikus yang mengalami periodontitis apikalis kronis dapat memperbaiki histopatologi hati.
ИНТЕГРАЦИЈА РЕЛАЦИОНЕ И ГРАФОВСКЕ БАЗЕ ПОДАТАКА ЗА ПОДРШКУ РАДА ИНФОРМАЦИОНОГ СИСТЕМА ДРУШТВЕНЕ МРЕЖЕ
Authors: Говорчин Тамара 
Published: March 2023

У овом раду описане су релациона и графовска база података, као и проблеми на које се може наићи приликом коришћења само релационе базе података. Такође су наведени начини на које графовска база може да превазиђе поједине недостатке релационе базе података. На основу свих прикупљених информација, истражен је начин за интеграцију релационе и графовске базе података. У оквиру рада, такође је описан информациони систем друштвене мреже, који представља приказ случаја коришћења решења које је претходно изведено. Циљ изабраног дела информационог система је да олакша процес повезивања корисника у виду изражавања пријатељства у оквиру друштвене мреже, као и да омогући додавање и прегледање фотографија са додатним информацијама. Концептуална шема базе података пројектована је помоћу алата lucid-app, а од база података су коришћене MySQL као релациона база података и Neo4j као графовска база података.
Optimal Adsorptive Bleaching of Palm Oil with Activated Beans Husks
Authors: Olufemi Babatope Abimbola , Damola-Okesiji Adedoyin T. 
Published: March 2023

The effectiveness of activated bean husks for the adsorptive bleaching of palm oil was studied in this work. Optimal bleaching parameters like temperature, time and adsorbent-oil ratio were determined for the palm oil decolouration. Various weights of 1, 1.5 and 2 g of activated beans husks were contacted with crude palm oil at 50, 80, 110, 140 and 170 °C and contact times of 45, 60 and 90 minutes using 20 ml of oil sample in each case. The decolorizing effect increased linearly with temperature. Optimal adsorption conditions gave a bleaching efficiency of 98%. Langmuir, Freundlich, Temkin with Dubinin-Radushkevich isotherms were correlated, and Freundlich has the highest statistical correlation coefficient (R2) value of 0.9901. Dubinin-Radushkevich isotherm suggested chemisorption. The pseudo-second-order model provided the best fit for the kinetic study.