bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paederia Foetida Linn (Rubiaceae): Chemical Diversity, Phytopharmacological Potential, Quantitative Analysis and Clinical Approaches
Authors: Dwivedi Jyotsana , Wal Pranay , Wagh Vijay D. , Sachan Pranjal , Joshi Neha Shukla , Goyal Swapnil , Tripathi Arpan Kumar 
Published: January 2025

Abstract:
The discovery of novel counteractive pharmaceuticals, which have recently generated
much interest, has played a significant role in the development of drugs derived from herbal
medicines or botanical sources. Paederia foetida (P. foetida) is one such example of a role in
both traditional and traditional medicine. Owing to its popularity in folk medicine, it has been
the subject of intense pharmacological and chemical studies for the last 30 years. They are locally
known as "Gandhavadulia" or "GandhaPrasarini" (English name "skunkvine") and belong to
the family Rubiaceae. This plant has a broad range of applications in the treatment of several illnesses,
including anti-inflammatory, antinociceptive, antitussive, thrombolytic, antidiabetic, antihyperlipidaemic,
antioxidant, nephroprotective, anti-inflammatory, hepatoprotective, anthelmintic,
and antidiarrheal effects. Additionally, it contains a variety of phytochemicals, such as
asperuloside, paederosidic acid, sitosterols, campesterol, lignans, alkaloids, volatile oils, iridoids,
methylindooxy substances, stigmasterol, tannins, triterpenoids, ellagic acid, ursolic acid,
epifriedelinol, and phenolic compounds. Recently, mounting data on numerous active ingredients
have indicated that they may be beneficial for spermatogenesis, wound healing, inflammatory
illnesses, and cancer. This review describes the phytochemistry and mechanisms of action
of these pharmacological effects and provides insights into potential pharmacological targets.
These results highlight the need for additional studies on this medicinal plant and the investigation
of new counteractive medications to determine their mode of action before use in
healthcare.
Integrated Network Pharmacology and Transcriptomics Analysis to
Elucidate the Mechanism of Huoxue Tongluo Qiwei Decoction in the
Treatment of Erectile Dysfunction in Spontaneously Hypertensive Rats
through Angii-Activated Pkcε Pathway
Authors: Feng Junlong , Deng Sheng , Wang Bin , Zhao Cong , Zou Kali , Li Haisong , Wang Jisheng 
Published: January 2025

Background and Aim:
As a classical formula to invigorate blood circulation, Huoxue
Tongluo Qiwei Decoction (HTQD) can effectively treat hypertensive erectile dysfunction (ED),
but its exact mechanism of action is not yet clear. The goal of this research was to explore the
potential mechanism of HTQD in improving hypertensive erectile dysfunction in rats through
transcriptomics, network pharmacology, and associated animal experimentations.

Methods:
The HTQD chemical constituents were screened using high-performance liquid chromatography-
tandem mass spectrometry (HPLC-MS/MS). Furthermore, transcriptomics analysis
was performed via mRNA sequencing to identify significantly differentially expressed proteins.
Moreover, the key target proteins of HTQD in the treatment of hypertensive ED were screened
by network pharmacology and transcriptomics. In addition, the endothelial cells of the corpus
cavernosum were assessed using hematoxylin-eosin staining. The transcript and protein expressions
were evaluated via western blotting and Real-time reverse transcription-quantitative polymerase
chain reaction (RT-qPCR).

Results:
The network pharmacology and transcriptome mRNA sequencing revealed that KCNE1
may be the target protein of HTQD in improving hypertensive ED. After HTQD treatment, the
systolic and diastolic blood pressure (BP) of hypertensive rats decreased, the number of erections
increased, and the pathological structure of the penis was improved. Moreover, HTQD downregulated
the protein and mRNA expression of AngII, AT1R, DAG, and PKCε, whereas it upregulated
the transcript and protein expression of KCNE1.

Conclusion:
HTQD may activate the PKCε pathway through AngII, inhibit the expression of
KCNE1 protein, relax vascular smooth muscles, and improve erectile function.
Molecular and Functional Significance of Growth Differentiation Factor-15: A Review on Cardiovascular-Kidney-Metabolic Biomarker
Authors: Tiwari Krishna , Saravanan Aswini , Anil Abhishek , Tiwari Vikas Kumar , Shamim Muhammad Aaqib , Singh Surjit , Dwivedi Pradeep , Deora Surender , Varthya Shoban Babu 
Published: January 2025

Abstract:
Cardiovascular-kidney-metabolic (CKM) syndrome is the association between obesity,
diabetes, CKD (chronic kidney disease), and cardiovascular disease. GDF-15 mainly acts
through the GFRAL (Glial cell line-derived neurotrophic factor Family Receptor Alpha-Like)
receptor. GDF-15 and GDFRAL complex act mainly through RET co-receptors, further activating
Ras and phosphatidylinositol-3-kinase (PI3K)/Akt pathways through downstream signaling.
GDF-15 decreases cardiac dysfunction and hypertrophy by inducing HIF-α (hypoxia-inducible
factor-1α). It causes increased fractional shortening and a significant decrease in ventricular dilation
through the induction of the SMAD 2/3. GDF-15 prevents hyperglycemia-induced apoptosis
in diabetes mellitus. GDF-15 causes anorexia by influencing the central systems regulating metabolism
and appetite. Therefore, targeting GDF-15 can be useful for the treatment of anorexia
caused by cancer as well as the prevention of resulting weight loss. GDF-15 has an important
role in predicting mortality in acute kidney injury. Its high levels are related to eGFR decline and
also have a prognostic role in CKD patients. Growth differentiation factor-15 (GDF-15) is a vital
biomarker for diagnosis, treatment, and prognosis of CKM syndrome. Elevated GDF-15 levels
can be utilised as a biomarker to determine the suitable metformin dosage. In light chain amyloidosis,
a raised level of GDF-15 predicts early death in heart failure and renal disease patients. In
vivo, studies using GDF-15 analogs and antibodies against GFRAL to affect metabolic parameters
and ventricular dilatation have shown potential for GDF-15-based therapeutic interventions.
This review aims to study the role of GDF-15 in CKM syndrome and establish it as a CKM biomarker.
Marine-Derived Compound Targeting mTOR and FGFR-2: A Promising Strategy for Breast, Lung, and Colorectal Cancer Therapy
Authors: Mythili Vijay Murali Ravi , K Kumaran , Chattopadhyay Sayantani , Basha Shahjahan Ahmad , Sekar Sruthi , Senthil Sowmya , D Prabhu , Rangasamy Kirubakaran , ArulJothi KN 
Published: January 2025

Introduction:
The marine habitat is a plentiful source of diverse, active compounds that
are extensively utilised for their medicinal properties. Pharmaceutical trends have currently
changed towards utilising a diverse range of goods derived from the marine environment.

Method:
This study aimed to examine the inhibitory effects of bioactive chemicals derived from
marine algae and bacteria. The identification of these compounds was carried out through the process
of Gas Chromatography-Mass Spectrometry (GC-MS) profiling. Subsequently, these compounds
were subjected to docking simulations against a specific set of target proteins that are
known to be frequently overexpressed in three distinct types of cancer.

Result:
From the docking results, the ligand 1,4:3,6:5,7-Tribenzal-beta-mannoheptitol was found to
be effective against the proteins mTOR (PDB ID: 4JSV) and FGFR2 (PDB ID:6V6Q). The findings
of this study highlight the significant benefits offered by the tool under investigation, which effectively
enhances the efficiency of the docking procedures.

Conclusion:
These compounds hold significant potential for further development and exploration
in the field of cancer therapeutics.
Jellyfish Collagen as a Promising Source for Nutraceutical and Biomedical Applications
Authors: James Saira , Tilvi Supriya 
Published: January 2025

Abstract:
Jellyfish blooms have become increasingly common worldwide, driven by climate
change, eutrophication, and the jellyfish’s unique life cycle. The rich protein derived from these
resources notably, jellyfish collagen (JFC) and its hydrolysates (JFCH) peptides stands out as
promising, sustainable alternatives to traditional collagen sources like bovine and rat tail collagen.
Notably, JFC carries a reduced risk of prion and viral contamination, making it a safer option for
diverse applications. As a fundamental collagen form, JFC is compatible with various cell types,
enhancing its utility across multiple domains. Furthermore, JFCH peptides act as potent bioactive
ingredients, especially in the food industry, where their high antioxidant properties are valued in
nutraceutical formulations. Immunological research also suggests that JFC can promote
immunoglobulin production and stimulate cytokine synthesis, revealing its potential for immune
system support. Due to its versatility, JFC can facilitate the growth of various human cell types,
positioning it as an effective biomaterial for wound care, tissue engineering, cartilage regeneration,
drug delivery, and cell culture applications. This review highlights recent advancements in JFC and
JFCH applications across nutraceuticals, immunology, wound healing, tissue engineering, and
regenerative medicine in —those not extensively covered in previous literature.
Screening of Candidate Chemical Regulators for the m6A Writer MTA in Arabidopsis
Authors: Lei Beilei , Jia Chengchao , Tan Cuixia , Ding Pengjun , Li Zenglin , Yang Jing , Liu Jiyuan , Wei Xiaomin , Tao Shiheng , Ma Chuang 
Published: January 2025

Background:
The MTA gene encodes a core component of m6A methyltransferase complex,
which plays a crucial role in the post-transcriptional modification of RNA that influences
many vital processes in plants. However, due to the constraint of embryonic lethality in MTA
knockout mutation, the molecular function of MTA gene has yet to be comprehensively investigated.

Objective:
The aim of this study is to investigate the expression and regulation of MTA in Arabidopsis.

Methods:
A large-scale transcriptome and genome analysis were carried out for the expression and
nsSNP (non-synonymous Single Nucleotide Polymorphism) studies. Structured-based virtual screening,
molecular dynamics simulation, binding free energy calculation and m6A modification level assay
were employed to mine and validate MTA regulators from COCONUT natural product database.

Results:
Tissue-specific expression and stress-responsive expression patterns of MTA were observed
in Arabidopsis. nsSNPs from the 1,001 Arabidopsis project were not detected in the binding
site of the methyl-donor substrate S-adenosylmethionine (SAM) in MTA. 10 small molecules were
identified as potential regulators, among which CNP0251613 (adenosine diphosphate glucose,
ADPG) was selected and validated to decrease m6A levels at 10 μM vs. the control in Arabidopsis.

Conclusion:
Our results provide a new insight and chemical entity into the in-depth study of RNA
m6A writer MTA in plants.
Research on Controllable Synthesis and Growth Mechanism of Sodium Vanadium Fluorophosphate Nanosheets
Authors: Yuan Xinran , Teng Aijun , Liu Tianhao , Yang Yadong , Xin Yanan , Yong Lingling , Zhang Dongbin 
Published: January 2025

Background:
Sodium vanadium fluorophosphate is a sodium ion superconductor material
with high sodium ion mobility and excellent cyclic stability, making it a promising cathode material
for sodium-ion batteries. However, most of the literature and patents report preparation through
traditional methods, which involve complex processes, large particle sizes, and low electronic conductivity,
thereby limiting development progress.

Objective:
Aiming at the limitation of high cost and poor performance of vanadium sodium fluorophosphate
cathode material, the low temperature and high-efficiency nano preparation technology
was developed.

Methods:
This study uses a homogenizer with high dispersion and shear force to directionally control
the collision of sodium vanadium fluorophosphate nanoparticles with higher specific surface
energy during the initial nucleation stage, forming nanosheet structures.

Results:
The growth mechanism of these nanosheets was analyzed using SEM, XRD, AFM, and
DFT simulation. Results indicate that the crystal surfaces with higher surface energy undergo directional
collisions in the early nucleation stage, gradually reducing the surface energy and stabilizing
the system, resulting in sodium vanadium fluorophosphate nanosheets.

Conclusion:
Due to the larger specific surface area and pore structure, these nanosheets exhibit excellent
rate performance and cycle stability, making them suitable for application and promotion in
the field of fast-charging energy storage.
Recent Advances in Nanoformulations of Citrus Bioactives & Potential Health Benefits
Authors: Verma Minakshi , Das Alok Kumar 
Published: January 2025

Abstract:
Citrus fruits are widely recognized not only for their refreshing taste but also for their
rich content of bioactive compounds, including flavonoids, carotenoids, and essential oils. The molecular
mechanisms through which citrus-derived compounds exert their effects highlight their antioxidant,
anti-inflammatory, anticancer, and cardioprotective properties. Flavonoids, such as hesperidin
and naringin, exhibit potent antioxidant and anti-inflammatory properties, reducing oxidative
stress and inflammation-related diseases. Carotenoids like beta-cryptoxanthin and lutein offer protective
effects against various cancers and support eye health. The essential oils, dominated by limonene,
show promising anticancer, antimicrobial, and cardioprotective effects. The role of citrus bioactive
in modulating metabolic pathways, improving immune function, and promoting gut health.
Nanoformulation of citrus-based compounds involves the development of nanometer-scale formulations
of active ingredients derived from citrus plants. These formulations show the promising effect
of preventing and managing chronic diseases such as diabetes, cardiovascular diseases, and certain
types of cancer. The bioavailability and metabolism of citrus bioactive, emphasizing the importance
of food matrix interactions and individual variability. By exploring current research, it is easy to
understand the health benefits of citrus fruits and their therapeutic potential in nutritional science
and preventive medicine.
Isolation and Structural Determination of Cyclic Dipeptides Produced by Arthrobacter sp.
Authors: Arije Amonah T. , Agbakpo Andy E. , Patel Shivam G , Fox Sean J. , Shilabin Abbas G. 
Published: January 2025

Introduction:
Arthrobacter is a genus of bacteria that has gained recent attention due to
its unique ability to produce bioactive compounds that possess potential antimicrobial properties.

Method:
In this study, we isolated two cyclic dipeptides (CDPs) from Arthrobacter sp. obtained
from a soil sample.

Result:
The isolated Arthrobacter sp. exhibited inhibitory activity against a filamentous indicator
bacterium and a violacein-producing Janthinobacterium sp. Cultivation of Arthrobacter sp.
TAJX1902 was carried out using rich medium broth and agar to facilitate the extraction of metabolites.
The isolated compounds were characterized through spectroscopic techniques. GCMS analysis
of the crude extract revealed the presence of bioactive cyclic dipeptides.

Conclusion:
The structures of the isolated CDPs were determined as acylated cyclo(Dphenylalanine-
4-hydroxy-D-proline) (1) and cyclo(D-phenylalanine-D-proline) (2). Furthermore,
two additional metabolites, 2,4-dihydroxypyrimidine (3) and 2,4-dihydroxy-5-methylpyrimidine (4),
were identified and verified through NMR spectral analysis.
Lavender Oil: A Versatile Natural Therapeutic – Extraction, Composition, Applications, and Innovative Formulation Strategies
Authors: Shaikh Farooque , Harde Manoj , Mallya Rashmi 
Published: January 2025

Abstract:
The present review comprehensively explores an overview of a versatile essential oil from
genus Lavandula. Oil finds wide application in the aromatherapy and cosmetic industry. This paper
emphasizes the chemical constituents of the oil that are responsible for the diverse therapeutic applications.
Various extraction techniques, such as steam distillation, hydro distillation, supercritical
liquid extraction and ultrasound assisted extraction are discussed. Also the article elucidates the
mechanism of action that explains the therapeutic application of the oil in microbial infections, oxidative
stress and neurodegenerative diseases. This review also extensively discusses the preclinical
and clinical studies of the use of the oil for the management or treatment of psoriasis, depression,
wound, anxiety, Alzheimer’s’ disease, myocardial infarction, acute lung injury and acute inflammation.
Additionally, the article highlights granted patents and the novel formulation strategies such as
hydrogels, nanofibers, emulsions and nanoparticles used to enhance the bioavailability and the targeted
delivery of the oil. The review also provides future perspectives, emphasizing the need for
further research for harnessing the potential of lavender oil.
Preparation, Computational and Spectroscopic Analysis of an Efficient Medicinal Molecule: 4-Bromoquinoline-2-carboxaldehyde
Authors: Mir M. Amin 
Published: January 2025

Introduction:
This paper presents the synthesis, spectroscopic characterization, and
computational modeling of 4-Bromoquinoline-2-carboxaldehyde (4-BQCA), an effective therapeutic
compound. 4-BQCA, a quinoline derivative, has drawn interest because of its distinct chemical
structure and its medical uses.

Method:
The chemical was produced with excellent yield and purity using a simple, repeatable
reaction route. Density functional theory (DFT) studies were carried out to learn more about the
compound's molecular characteristics, including its electronic structure, bonding, and stability. The
structure and functional groups found in 4-BQCA were verified by spectroscopic investigation,
which included UV-Vis, FT-IR, NMR, and mass spectrometry.

Result:
The compound's stability and advantageous electrical characteristics are highlighted by the
results of both computational and experimental methods, indicating that it may find application in
medication design and development.

Conclusion:
These results offer a starting point for further investigations into the biological activity
and therapeutic effectiveness of 4-BQCA, indicating that it is a viable option for more study in
pharmaceutical applications.
Pelabelan Total Koprima
Authors: Komarullah Hafif 
Published: January 2025

Pelabelan total koprima merupakan pengembangan dari pelabelan prima. Pelabelan total prima pada graf adalah suatu fungsi injektif sedemikian sehingga jika dengan , maka setiap titik yang bertetangga relatif prima dan setiap label sisi-sisi yang bersisian dengan satu titik harus relatif prima. Nilai minimum pada pelabelan titik dan sisi prima pada graf disebut total coprime number yang dinotasikan dengan Penelitian ini termasuk penelitian eksploratif yang bertujuan untuk menambah wawasan atau pengetahuan dan memunculkan gagasan baru pada teori graf khususnya dalam topik pelabelan graf. Dalam penelitian ini diperoleh bahwa total coprime number pada graf lintasan dan graf cycle berturut-turut adalah dan
Development and Validation of a Routine Electronic Health Record-Based Delirium Prediction Model for Surgical Patients Without Dementia: Retrospective Case-Control Study
Authors: Holler Emma , Ludema Christina , Ben Miled Zina , Rosenberg Molly , Kalbaugh Corey , Boustani Malaz , Mohanty Sanjay 
Published: January 2025

Background
Postoperative delirium (POD) is a common complication after major surgery and is associated with poor outcomes in older adults. Early identification of patients at high risk of POD can enable targeted prevention efforts. However, existing POD prediction models require inpatient data collected during the hospital stay, which delays predictions and limits scalability.

Objective
This study aimed to develop and externally validate a machine learning-based prediction model for POD using routine electronic health record (EHR) data.

Methods
We identified all surgical encounters from 2014 to 2021 for patients aged 50 years and older who underwent an operation requiring general anesthesia, with a length of stay of at least 1 day at 3 Indiana hospitals. Patients with preexisting dementia or mild cognitive impairment were excluded. POD was identified using Confusion Assessment Method records and delirium International Classification of Diseases (ICD) codes. Controls without delirium or nurse-documented confusion were matched to cases by age, sex, race, and year of admission. We trained logistic regression, random forest, extreme gradient boosting (XGB), and neural network models to predict POD using 143 features derived from routine EHR data available at the time of hospital admission. Separate models were developed for each hospital using surveillance periods of 3 months, 6 months, and 1 year before admission. Model performance was evaluated using the area under the receiver operating characteristic curve (AUROC). Each model was internally validated using holdout data and externally validated using data from the other 2 hospitals. Calibration was assessed using calibration curves.

Results
The study cohort included 7167 delirium cases and 7167 matched controls. XGB outperformed all other classifiers. AUROCs were highest for XGB models trained on 12 months of preadmission data. The best-performing XGB model achieved a mean AUROC of 0.79 (SD 0.01) on the holdout set, which decreased to 0.69-0.74 (SD 0.02) when externally validated on data from other hospitals.

Conclusions
Our routine EHR-based POD prediction models demonstrated good predictive ability using a limited set of preadmission and surgical variables, though their generalizability was limited. The proposed models could be used as a scalable, automated screening tool to identify patients at high risk of POD at the time of hospital admission.