bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual action of macrophage miR‐204 confines cyclosporine A‐induced atherosclerosis
Authors: Su Jia‐Hui , Hong Yu , Han Cong‐Cong , Yu Jie , Guan Xin , Zhu Ya‐Mei , Wang Cheng , Ma Ming‐Ming , Pang Rui‐Ping , Ou Jing‐Song , Zhou Jia‐Guo , Zhang Zi‐Yi , Ban Tao , Liang Si‐Jia 
Published: September 2023

Background and PurposeAtherosclerosis induced by cyclosporine A (CsA), an inhibitor of the calcineurin/nuclear factor of activated T cells (NFAT) pathway, is a major concern after organ transplantation. However, the atherosclerotic mechanisms of CsA remain obscure. We previously demonstrated that calcineurin/NFAT signalling inhibition contributes to atherogenesis via suppressing microRNA‐204 (miR‐204) transcription. We therefore hypothesised that miR‐204 is involved in the development of CsA‐induced atherosclerosis.Experimental ApproachApoE−/− mice with macrophage‐miR‐204 overexpression were generated to determine the effects of miR‐204 on CsA‐induced atherosclerosis. Luciferase reporter assays and chromatin immunoprecipitation sequencing were performed to explore the targets mediating miR‐204 effects.Key ResultsCsA alone did not significantly affect atherosclerotic lesions or serum lipid levels. However, it exacerbated high‐fat diet‐induced atherosclerosis and hyperlipidemia in C57BL/6J and ApoE−/− mice, respectively. miR‐204 levels decreased in circulating monocytes and plaque lesions during CsA‐induced atherosclerosis. The upregulation of miR‐204 in macrophages inhibited CsA‐induced atherosclerotic plaque formation but did not affect serum lipid levels. miR‐204 limited the CsA‐induced foam cell formation by reducing the expression of the scavenger receptors SR‐BII and CD36. SR‐BII was post‐transcriptionally regulated by mature miR‐204‐5p via 3′‐UTR targeting. Additionally, nuclear‐localised miR‐204‐3p prevented the CsA‐induced binding of Ago2 to the CD36 promoter, suppressing CD36 transcription. SR‐BII or CD36 expression restoration dampened the beneficial effects of miR‐204 on CsA‐induced atherosclerosis.Conclusion and ImplicationsMacrophage miR‐204 ameliorates CsA‐induced atherosclerosis, suggesting that miR‐204 may be a potential target for the prevention and treatment of CsA‐related atherosclerotic side effects.
Combination of PARP inhibitor and CDK4/6 inhibitor modulates cGAS/STING‐dependent therapy‐induced senescence and provides “one‐two punch” opportunity with anti‐PD‐L1 therapy in colorectal cancer
Authors: Wang Tao , Liu Weizhen , Shen Qian , Tao Ruikang , Li Chengguo , Shen Qian , Lin Yao , Huang Yongzhou , Yang Lei , Xie Gengchen , Bai Jie , Li Ruidong , Wang Lulu , Tao Kaixiong , Yin Yuping 
Published: September 2023

AbstractAlthough PARP inhibitor (PARPi) has been proven to be a promising anticancer drug in cancer patients harboring BRCA1/2 mutation, it provides limited clinical benefit in colorectal cancer patients with a low prevalence of BRCA1/2 mutations. In our study, we found PARPi talazoparib significantly induced cellular senescence via inhibiting p53 ubiquitination and activating p21. Furthermore, CDK4/6i palbociclib amplified this therapy‐induced senescence (TIS) in vitro and in vivo. Mechanistically, talazoparib and palbociclib combination induced senescence‐associated secretory phenotype (SASP), and characterization of SASP components revealed type I interferon (IFN)‐related mediators, which were amplified by cGAS/STING signaling. More importantly, RNA sequencing data indicated that combination therapy activated T cell signatures and combination treatment transformed the tumor microenvironment (TME) into a more antitumor state with increased CD8 T cells and natural killer (NK) cells and decreased macrophages and granulocytic myeloid‐derived suppressor cells (G‐MDSCs). Moreover, clearance of the TIS cells by αPD‐L1 promoted survival in immunocompetent mouse colorectal cancer models. Collectively, we elucidated the synergistic antitumor and immunomodulatory mechanisms of the talazoparib–palbociclib combination. Further combination with PD‐L1 antibody might be a promising “one‐two punch” therapeutic strategy for colorectal cancer patients.
Developmental trajectories of achievement emotions in mathematics during adolescence
Authors: Sakaki Michiko , Murayama Kou , Frenzel Anne C. , Goetz Thomas , Marsh Herbert W. , Lichtenfeld Stephanie , Pekrun Reinhard 
Published: September 2023

AbstractThis study examined how adolescents' emotions in mathematics develop over time. Growth curve modeling was applied to longitudinal data collected annually from 2002 to 2006 (Grades 5–9; N = 3425 German adolescents; Mage = 11.7, 15.6 years at the first and last waves, respectively; 50.0% female). Results indicated that enjoyment and pride decreased over time (Glass's Δs = −.86, −.71). In contrast, negative emotions exhibited more complex patterns: Anger, boredom, and hopelessness increased (Δs = .52, .79, .26), shame decreased (Δ = −.12), and anxiety remained stable (Δ = .00). These change trajectories of emotions were associated with change trajectories of perceived control, intrinsic value, achievement value, and achievement in mathematics. Implications and future directions are discussed.
Usage and coordination of governance principles to address proximate and distal drivers of conflicts in fisheries commons
Authors: McClanahan Tim R. 
Published: September 2023

AbstractCommons’ problems and solutions have the elements of local, proximate, and large‐scale distal processes. Solutions, therefore, require accessing, implementing, and coordinating information and actions at multiple scales. Restoring commons, such as fisheries, will require a better understanding of how stakeholders access and use information at various scales to resolve governance and restrictions problems. In 179 household interviews, perceptions of fisheries conflicts and their causes were identified, and 16 management committee key informants described their methods for mediating hypothetical small‐scale fisheries problems in Kenya. The 6 studied sites varied in human development and demographic contexts but had notable similarities that reflected a respondent's focus on localized, direct, and proximate fishing conflicts. The most cited problems included limited space, disagreement about gears, poor resource conditions, and locally inadequate benefits. The most cited sources of information were local households and the community, and there was considerably less acknowledgment of distal problems and solutions. Key informants selected a limited number of local community‐focused solutions. For example, informants chose to mediate conflicts between neighbors with local community meetings rather than through formal national institutions. Therefore, distal solutions were likely to be perceived as ineffectual, possibly due to the challenges of polycentric governance coordination. However, widespread overfishing arises from overarching distal processes not fully amenable to local solutions. Therefore, a focus on local action is expected to limit the ability to address distal problems. These include conflicting values, demographic changes, supportive governance frameworks, emerging technologies, resolving conflicting local rules, fair between‐group enforcement, responding to temporary shortages of fish, and intercommunity border and rule disputes. Improved coordination and integration of information and institutions to simultaneously address both proximate and distal common's problems are recommended.
Impact on species' online attention when named after celebrities
Authors: Blake Katie , Anderson Sean C. , Gleave Adam , Veríssimo Diogo 
Published: September 2023

AbstractCelebrities can generate substantial attention and influence public interest in species. Using a large‐scale examination of publicly available data, we assessed whether species across 6 taxonomic groups received more page views on Wikipedia when the species was named after a celebrity than when it was not. We conducted our analysis for 4 increasingly strict thresholds of how many average daily Wikipedia page views a celebrity had (1, 10, 100, or 1000 views). Overall, we found a high probability (0.96–0.98) that species named after celebrities had more page views than their closest relatives that were not named after celebrities, irrespective of the celebrity threshold. The multiplicative effect on species’ page views was larger but more uncertain as celebrity page‐view thresholds increased. The range for thresholds of 1 to 1000 was 1.08 (95% credible interval [CI] 1.00–1.18) to 1.76 (95% CI 0.96–2.80), respectively. The hierarchical estimates for the taxa tended to be positive. The strongest effects were for invertebrates, followed by amphibians, reptiles, fish, and mammals, whereas the weakest effect was for birds at lower page‐view thresholds. Our results suggest that naming species after celebrities could be particularly significant for those belonging to taxonomic groups that are generally less popular than others (e.g., invertebrates). Celebrities may further influence the effectiveness of this marketing strategy, depending on their likability and connection to the species named after them. Eponyms may serve as a reminder of the disproportionate power dynamics between populations and some namesakes’ untenable actions. However, they also provide an opportunity to recognize remarkable individuals and promote equity, inclusivity, and diversity in taxonomic practice. We encourage taxonomists to examine whether naming threatened species after celebrities could affect conservation support, especially for species that are otherwise typically overlooked by the public.
Chief executive officer private firm experience and idiosyncratic risk
Authors: Mishra Dev R. 
Published: September 2023

AbstractResearch Question/IssueWe examine chief executive officers' (CEOs) lifetime work experience in private firms and its potential influence in shaping managers' style in public firms and their corporate policies and thus the market's perception of a firm's risk.Research Findings/InsightsWe find that the idiosyncratic risk of public firms increases with the extent of CEO work experience in privately owned firms (CEO private experience). While there is no evidence of higher investment risk taking by private CEOs, the proportion of private‐firm work experience has a positive association with disclosure deficiency, decrease in manager‐owner agency conflicts, and an increase in political risk revelations at earnings conference calls, which, in turn, are associated with the elevation of idiosyncratic risk.Theoretical/Academic ImplicationsThe findings of this study underscore arguments in the upper echelons theory, imprinting theory, and behavioral agency theory. The study also has implications for literature related to corporate disclosure, governance, and political risk.Practitioner/Policy ImplicationsIdiosyncratic risk is important for firms, as the literature suggests it hurts a firm's ability to finance future capital investments; therefore, it is optimal for corporate boards to have strategies in place to monitor and offer orientation packages targeted at alleviating CEO style heterogeneities presented by their prior work experience in private firms.
Electrochromic materials: Scope for the cyclic decay mechanisms and performance stability optimisation strategies
Authors: Wu Yue , Mishra Yogendra Kumar , Xiong Jian 
Published: September 2023

AbstractElectrochromic materials (ECMs) have important potential applications in the field of intelligent optoelectronic displays. However, ECMs and its devices cannot be truly applied on a large scale until the problem of their long‐period performance degradation is really solved. This article focuses on summarising the attenuation mechanism of common ECMs, which is mainly divided into three types: structural damage, irreversible reaction and ion capture, and summarises four optimisation strategies for the cyclic stability of ECMs at the present stage: doping is used to change the internal structure of the material in order to achieve the purpose of improving the cyclic stability; composite means to allow a variety of materials to interact with each other in order that the original material has no excellent performance; improve the cyclic stability of ECMs by the special characteristics of nanostructures; and enhance the performance by optimising the preparation process and regulating the parameters in the preparation process. Finally, the article discusses the potential for optimising the long‐term stability of ECMs in the future, based on the earlier‐mentioned research.
Opportunities and challenges of 5G network technology toward precision medicine
Authors: Kang Chia Chao , Lee Tze Yan , Lim Wai Feng , Yeo Wendy Wai Yeng 
Published: September 2023

AbstractMoving away from traditional “one‐size‐fits‐all” treatment to precision‐based medicine has tremendously improved disease prognosis, accuracy of diagnosis, disease progression prediction, and targeted‐treatment. The current cutting‐edge of 5G network technology is enabling a growing trend in precision medicine to extend its utility and value to the smart healthcare system. The 5G network technology will bring together big data, artificial intelligence, and machine learning to provide essential levels of connectivity to enable a new health ecosystem toward precision medicine. In the 5G‐enabled health ecosystem, its applications involve predictive and preventative measurements which enable advances in patient personalization. This review aims to discuss the opportunities, challenges, and prospects posed to 5G network technology in moving forward to deliver personalized treatments and patient‐centric care via a precision medicine approach.
Reconsideration of the current models of estimated kidney function‐based drug dose adjustment in older adults: The role of biological age
Authors: Alikhani Radin , Pai Manjunath P. 
Published: September 2023

AbstractHuman lifespan has increased from a median of 46.5 years in 1950 to 71.7 years in 2022. As people age, one of the inevitable consequences is a decline in kidney function and glomerular filtration rate (GFR) which can have direct or indirect effects on the pharmacokinetic and pharmacodynamic profiles of many drugs. Numerous equations have been developed to generate estimated GFR (eGFR) using the two principal biomarkers: serum creatinine and serum cystatin C. However, the trajectory of changes with aging is dissimilar in these equations. In addition, there is recognition that chronological age (lifespan) often does not reflect biological age (healthspan) as an essential parameter in kidney function equations. In the past decade, there has been an increasing interest in quantifying biological age and new commercially available assays have entered the marketplace. In this narrative review, we illustrate how dominant equations of eGFR model the fractional change in this parameter very differently across chronological age. In addition, we review various biological age indicators (aging clocks) and challenges to their application in clinical practice. Importantly, by comparing vancomycin's mean clearance as a drug with limited metabolism and unchanged elimination between two age milestones in some recent population pharmacokinetic models, we show how efforts to quantify kidney function in older adults optimally remain under‐explored, particularly those at the upper end of their lifespan. We also propose considering new models that integrate biological age as a new pathway to improve precision drug dosing in older adults.
Forschung für die Praxis: Ernährung und Mikrobiom bei Autoimmunkrankheiten
Authors: Vorobyev Artem , Ludwig Ralf J. 
Published: September 2023

ZusammenfassungDie Häufigkeit von Autoimmunerkrankungen in Industrieländern hat während der letzten Jahrzehnte ständig zugenommen. Diese Erkrankungen führen zu erhöhter Sterblichkeit sowie anhaltender Beeinträchtigung der Lebensqualität der Patienten und bedeuten eine große medizinische Belastung. Die Behandlung von Autoimmunkrankheiten beruht häufig auf unspezifischer Immunsuppression, was das Risiko von Infektionskrankheiten und Krebsmanifestationen erhöht. Die Pathogenese von Autoimmunerkrankungen ist komplex und umfasst nicht nur genetische Faktoren, sondern auch Umwelteinflüsse, die als Grund für die Zunahme von Autoimmunerkrankungen angesehen werden. Zahlreiche Umweltfaktoren wie Infektionen, Rauchen, Medikamente oder Ernährung können das Auftreten von Autoimmunität entweder fördern oder verhindern. Die Mechanismen der Beeinflussung durch Umwelteinflüsse sind jedoch komplex und derzeit noch nicht eindeutig geklärt. Die Entschlüsselung dieser Wechselwirkungen könnte unser Verständnis der Autoimmunität verbessern und neue Behandlungsmöglichkeiten für die Patienten eröffnen.
Kompressionstherapie in der Dermatologie
Authors: Dissemond Joachim , Protz Kerstin , Stücker Markus 
Published: September 2023

ZusammenfassungDie Kompressionstherapie ist eine konservative Therapie, die bei vielen Patienten mit dermatologischen Krankheiten durchgeführt werden kann, insbesondere wenn diese mit Ödemen assoziiert sind. Neben den wissenschaftlich sehr gut belegten Indikationen bei venösen und lymphatischen Erkrankungen, gibt es auch zunehmend wissenschaftliche Hinweise, dass durch die Kompressionstherapie die Abheilung entzündlicher Dermatosen unterstützt wird. Wenn Ödeme vorliegen, handelt es sich, unabhängig von deren Genese, um einen Einsatz im Rahmen der Zulassung der Kompressionstherapie.Für die Kompressionstherapie stehen heute verschiedene Materialien und Versorgungsoptionen mit systemspezifischen Vor‐ und Nachteilen zur Verfügung. Oft ist eine Kompressionstherapie mit niedrigen Ruhedruckwerten für einen Therapieerfolg ausreichend und wird von den Patienten besser toleriert. Als wichtigste Kontraindikationen der Kompressionstherapie sind die fortgeschrittene periphere arterielle Verschlusskrankheit und die dekompensierte Herzinsuffizienz zu beachten.Bei der gemeinsam mit dem Patienten getroffenen Entscheidung für eine Kompressionstherapie, sollten individuelle Faktoren und wirtschaftliche Aspekte berücksichtigt werden. Wann immer möglich, ist ein Selbstmanagement des Patienten zu unterstützen. Hierfür sind Edukation und Hilfsmittel erforderlich.
S2k guideline diagnosis, prevention, and therapy of hand eczema
Authors: Bauer Andrea , Brans Richard , Brehler Randolf , Büttner Marion , Dickel Heinrich , Elsner Peter , Fartasch Manigé , Herzog Claudia , John Swen‐Malte , Köllner Arno , Maul Julia‐Tatjana , Merk Hans , Molin Sonja , Nast Alexander , Nikolakis Georgios D. , Schliemann Sybille , Skudlik Christoph , Weisshaar Elke , Werfel Thomas , Zidane Miriam , Worm Margitta 
Published: September 2023

SummaryThe consensus‐based guideline “Diagnosis, prevention, and treatment of hand eczema (HE)” provides concrete instructions and recommendations for diagnosis, prevention, and therapy of HE based on an evidence‐ and consensus‐based approach. The guideline was created based on the German guideline “Management von Handekzemen” from 2009 and the current guideline of the European Society of Contact Dermatitis (ESCD) “Guidelines for diagnosis, prevention, and treatment of hand eczema” from 2022. The general goal of the guideline is to provide dermatologists and allergologists in practice and clinics with an accepted, evidence‐based decision‐making tool for selecting and conducting suitable and sufficient therapy for patients with hand eczema. The guideline is based on two Cochrane reviews of therapeutic and preventive interventions for HE. The remaining chapters were mainly developed and consented based on non‐systematic literature research by the expert group. The expert group consisted of members of allergological and occupational dermatological professional associations and working groups, a patient representative, and methodologists. The proposals for recommendations and key statements were consented by using a nominal group process during a consensus conference on September 15, 2022. The structured consensus‐building process was professionally moderated. This guideline is valid until February 22, 2028.
The real‐world observational prospective study of health outcomes with dulaglutide and liraglutide in patients with type 2 diabetes (TROPHIES): Final, 24‐month analysis of time to first significant treatment change, treatment persistence and clinical outcomes
Authors: Giorgino Francesco , Guerci Bruno , Füchtenbusch Martin , Lebrec Jérémie , Boye Kristina , Orsini Federici Marco , Heitmann Elke , Dib Anne , Yu Maria , Sapin Hélène , García‐Pérez Luis‐Emilio 
Published: September 2023

AbstractAimsTo present the final results of the TROPHIES study (The real‐world observational prospective study of health outcomes with dulaglutide and liraglutide in patients with type 2 diabetes).Materials and MethodsThe prospective, real‐world TROPHIES study included patients with type 2 diabetes initiating their first injectable glucose‐lowering medication (GLM), dulaglutide or liraglutide, in France, Germany and Italy. The primary endpoint was the time spent on dulaglutide or liraglutide until a significant treatment change over 24 months. Other endpoints measured persistence with treatment, clinical outcomes (glycated haemoglobin [HbA1c] and weight) and treatment patterns. Kaplan‐Meier estimates of time to first significant treatment change and persistence with treatment were generated. Propensity‐score‐based inverse probability of treatment weighting (IPTW) was used to adjust for baseline imbalances in the comparison between cohorts.ResultsThe 286 of 1014 patients (28.2%) in the dulaglutide cohort and 448 of 991 patients (45.2%) in the liraglutide cohort had a significant treatment change over 24 months. By IPTW analysis, dulaglutide‐initiating patients were less likely to have a significant treatment change (hazard ratio [HR] 0.54, 95% confidence interval [CI] 0.46‐0.63) and more likely to be persistent with treatment (HR 0.69, 95% CI 0.56‐0.86) over 24 months than liraglutide‐initiating patients. Dulaglutide and liraglutide yielded similar HbA1c (−11.80 mmol/mol [1.08%] and −11.91 mmol/mol [1.09%]) and weight (−3.5 kg and −3.3 kg) reductions from baseline to 24 months. Few changes in patterns of treatment with other GLMs were observed in the two cohorts.ConclusionsDulaglutide‐initiating patients had a longer time spent without any significant treatment change and higher persistence than those initiating liraglutide. Treatment with either glucagon‐like peptide‐1 receptor agonist yielded similar and clinically meaningful reductions in HbA1c and body weight.
Metacommunity organisation of Amazonian stream fish assemblages: The importance of spatial and environmental factors
Authors: Martins André Ribeiro , Bastos Douglas Aviz , Sousa Leandro Melo , Giarrizzo Tommaso , Vieira Thiago Bernardi , Hepp Luiz Ubiratan 
Published: September 2023

AbstractMetacommunity theory seeks to explain how local and regional processes contribute to the organisation of biological communities. Recent conceptual frameworks of this theory indicate that the dynamics of populations and communities are jointly established by dispersal, species responses to environmental conditions and biotic interactions dependent on species density. Here, we use hierarchical joint species distribution modelling to verify the effects of environmental factors (at multiple spatial scales), drainage network configuration, spatial autocorrelation and interspecific interactions on the structure of fish assemblages in terra‐firme streams in the Eastern Brazilian Amazon. Thirty streams were sampled in two field surveys, and 89 species were collected in total. Our results confirm the effects of limited dispersal, environmental conditions (at multiple scales) and the configuration of the drainage network on the dynamics of these assemblages. Furthermore, our results suggest that interspecific interactions are less relevant for the structuring of fish metacommunities in small Amazonian headwater streams. Abiotic factors like drainage networks and environmental heterogeneity were better predictors of species distributions than co‐occurrence patterns with potential competitors or predators.