bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profil Tingkat Kebugaran Jasmani Peserta Ekstrakurikuler di Jenjang Menengah Pertama
Authors: Novian Rizki Galang Pamungkas  , Mashuri Eko Winarno  
Published: January 2025

Luaran dari kegiatan ekstrakurikuler satu diantaranya adalah prestasi. Sedangkan sukar mencapai suatu prestasi apabila tidak disertai jasmani yang bugar. Sehingga tujuan utama penelitian ini adalah mengevaluasi kebugaran jasmani peserta ekstrakurikuler. Metode yang dipilih adalah survei deskriptif dengan subjek penelitian sebanyak 63 peserta ekstrakurikuler olahraga dari empat cabang olahraga futsal, bola voli, bola basket dan jujitsu, dan tes kebugaran jasmani indonesia (TKJI) digunakan sebagai instrumen penelitian. Hasil penelitian memperoleh rata-rata di atas 2.5 dan persetanse antara 55.6% hingga 56.0% menunjukan bahwa mayoritas peserta ekstrakurikuler dari empat cabang olahraga memiliki tingkat kebugaran jasmani yang sedang. Evaluasi ini menunjukan perlunya perhatian lebih dalam pelaksanaan latihan ekstrakurikuler agar peserta dapat meningkatkan kebugaran jasmani mereka, terutama karena faktor-faktor seperti kurangnya semangat peserta dalam melakukan latihan dan frekuensi latihan yang hanya dilakukan satu kali dalam sepekan. Oleh karenanya, perhatian lebih dalam pelaksanaan latihan ekstrakurikuler sangat diperlukan agar peserta dapat mencapai tingkat kebugaran jasmani yang lebih optimal.
Komplex szövegértési vizsgálat első éves egyetemisták körében
Authors: Oláh Tibor 
Published: January 2025

A matematika és a nyelv kapcsolatának leírási és mérési lehetőségei közé tartozik
a szövegértés vizsgálata is. Ennek a kompetenciának széles körű alkalmazási területe
van. A szövegértés vizsgálata hozzájárul az absztraktív, logikai gondolkodás méréséhez.
A szövegértés mind az oktatásban, mind a munkaerőpiacon az érvényesülés, a sikeresség
egyik fontos része. Ezen képesség leírásához olyan mérési módszerre van szükség, amely
komplexebb módon írja le a kompetencia értelmezési szintjeit, esetleges deficitjét, s a
fejlesztés tartományait. Jelen mikrokutatás egyetemi hallgatók gondolkodásában mérte az
induktív és kombinatív gondolkodási képesség szintjét. A vizsgálat ezzel pontosabb képet
kívánt adni a szövegértés kombináltabb, absztraktabb mérési lehetőségeihez. Az
eredményeket mind a felsőoktatásban, mind a közoktatásban fel lehet használni.
A magyar felnőttek információfeldolgozási kompetenciáinak alakulása 2017/2018 és
2022/2023 között
Authors: Farkas Éva 
Published: January 2025

Az OECD 2024. december 10-én publikálta legújabb jelentését a felnőttek
kompetencia felmérésének eredményeiről[1]. A Felnőttek Nemzetközi Képesség- és
Kompetenciamérési Programja (Programme for the International Assessment of Adult
Competencies, továbbiakban: PIAAC) a 16-65 éves korosztály olyan transzferábilis
készségeit – szövegértés, számolási készség, adaptív problémamegoldás – mérte fel
2022/2023-ban, amelyek bármilyen szakmai környezetben felhasználhatóak, és a munkahelyi,
illetve a mindennapi életben való boldogulást és sikerességet pozitívan befolyásolják.
Míg a 2017/2018-as felmérésben a magyar felnőttek a szövegértésben és
problémamegoldásban az OECD-átlag körül, a számolási készség terén pedig az OECD-átlag
felett teljesítettek, addig a 2022/2023-as adatfelvételi ciklusban a munkaképes korú
felnőttek mindhárom mért kompetenciaterületen jelentősen az OECD átlag alatti
teljesítményt értek el. A magyar felnőttek a szövegértésben átlagosan 248 pontot (OECD
átlag: 260 pont), a számolási készségben 254 pontot (OECD átlag: 263 pont), az adaptív
problémamegoldásban 241 pontot értek el (OECD átlag: 251 pont). Ugyanakkor nem önmagában
ez az eredmény, hanem az a kedvezőtlen tendencia az igazán riasztó, hogy az 2017/2018.
évi 18,6 százalékról 2022/2023-ra 32,5 százalékra nőtt az alacsony szövegértési
készséggel, valamint 17,8 százalékról 28,8 százalékra nőtt az alacsony számolási
készséggel rendelkező felnőttek aránya (OECD, 2024). Ez a cikk a PIAAC felmérés
eredményeinek első „gyorsjelentését” kínálja a magyar helyzetre vonatkozóan.

[1] OECD (2024). Do Adults Have the Skills They Need to Thrive in a Changing World?:
Survey of Adult Skills 2023, OECD Skills Studies, OECD Publishing,
Paris, https://doi.org/10.1787/b263dc5d-en.
Formulasi Sediaan Sabun Cair Dari Ekstrak Kulit Pisang Kepok (Musa normalis L) Dengan Basis Minyak Inti Kelapa Sawit (Palm Carnel Oil)
Authors: Hermawan Gt Yudha , Noval Noval , Hidayah Nur , Audina Mia 
Published: January 2025

Latar belakang: kosmetik perawatan kulit adalah pembersih tubuh yang biasa disebut sabun. Sabun tersedia dalam bentuk sediaan dan tersedia dalam bentuk sediaan padat dan cair. Sabun cair merupakan sediaan yang banyak dipasarkan karena lebih mudah penggunaannya, kelebihan sabun cair adalah mudah dibawa, disimpan, dan lebih higienis serta tidak cepat kotor.Tujuan: Mengetahui pengaruh variasi konsentrasi minyak inti kelapa sawit (Palm karnel oil) terhadap formulasi optimal pada formulasi sabun cair ekstrak kulit pisang kepok (Musa normalis L) berdasarkan hasil evaluasi fisikokimiaMetode: Metode penelitian yang digunakan adalah eksperimental dan rancangan penelitian yang dilakukan adalah dengan perlakuan atau intervensi yang kemudian melakukan desain quasi experimental design dengan rancangan Non-equivalent control group design dan one group posttest-only designHasil: Hasil penelitian menunjukkan sediaan sabun cair dari ekstrak kulit pisang kepok (musa normalis l) dengan variasi minyak inti kelapa sawit menunjukkan memiliki pengaruh terhadap organoleptik,homogenitas, pH, viskositas, tinggi busa.Simpulan: Dari keempat formula tersebut dalam pembuatan sediaan sabun cair ekstrak kulit pisang kepok dengan variasi konsentrasi minyak inti kelapa sawit dari hasil semua evaluasi fisikokimia didapatkan hasil yang terbaik pada formula 1.
Genomic signatures of selection in Brangus cattle revealing the genetic foundations of adaptability and production traits using a breed of origin approach
Authors: Zayas Gabriel A. , Mateescu Raluca G. 
Published: January 2025

IntroductionThe composite breed Brangus combines the resilience and adaptability of the Bos t. indicus breed Brahman with the superior meat quality and fertility traits of the Bos t. taurus breed Angus. Its diverse genetics not only enables optimal production performance but also adaptability to hot and humid environmental conditions. From a research perspective, this makes Brangus an ideal model for identifying genomic signatures that reveal the effects of both artificial selection and natural adaptation. The aim of this study was to detect genomic signatures of selection by analyzing changes in breed origin of allele (BOA) frequencies across the genome.MethodsUsing a multi-breed Angus and Brahman herd (n = 4,516) as a reference, population structure was measured via principal component analysis and admixture analysis in two commercial Brangus herds (n = 4,720). BOA was estimated in these herds using LAMP-LD, followed by a signature of selection analysis utilizing a median-based Z-score approach and Fst analyses to detect genomic regions under selection.ResultsThe analysis revealed a genome-wide increase in Angus ancestry in both Brangus populations (71.46%, 68.7%), reflecting intense selection for traits associated with this lineage. BOA-based intra- and inter-population analyses identified significant shifts in Brahman and Angus ancestry across the genome, indicating potential selection for breed-specific genetics. Key genomic regions were identified on chromosomes 6, 8, 10, 12, 14, 17, 18, 19, 27, and 28, and were linked to traits such as fertility, growth, heat tolerance, carcass characteristics, and meat quality.DiscussionExpected genes showing signatures of selection included MC1R, responsible for black coat color, and PLAG1, integral to growth, fertility, and carcass traits, underscoring the effectiveness of this methodology. Novel genes under selection, such as CCNB2 (critical for fertility), MTCH2 (associated with meat quality and fertility) and PRLR (associated with coat length and heat tolerance), were also identified. These findings provide deeper insights into the genetic mechanisms driving adaptation and production performance in cattle and offer valuable information for strategic breeding practices aimed at optimizing the strengths of both parental breeds.
Determination of synbiotic mango fruit yogurt and its bioactive peptides for biofunctional properties
Authors: Minj Jagrani , Vij Shilpa 
Published: January 2025

Yogurt is one of the most popular fermented milk products consumed worldwide. Fortification of yogurt with different food components, including fruit pulp, is a common practice to make it more palatable and healthier. In India, mango fruit is easily available. It is rich in nutrients and bioactive components. However, in-depth studies on mango fruit yogurt are scarce. Therefore, in this study, we prepared synbiotic mango fruit yogurt using response surface methodology (RSM) with three different independent factors (sugar 4%–6%; prebiotic inulin 1%–3%, and mango pulp 5%–15%) to determine the response antioxidant activity. The optimal conditions were as follows: sugar 6%, mango fruit pulp 6.562%, and prebiotic inulin 1%. There were no significant differences between the results of the experimental and predicted values of antioxidant activity by this model. The optimized product was analyzed for physicochemical, biofunctional, and technofunctional properties, including total polyphenol content, total flavonoid content, proteolytic activity, antioxidant activity, and ACE-inhibitory activity. The bioactive peptides derived from synbiotic mango fruit yogurt were also extracted (3 kDa, 5 kDa and 10 kDa) and determined for their biofunctional attributes. The antioxidant activity was recorded as 1,047.95 ± 2.20 mmol/L, 1,208.07 ± 2.92 mmol/L, and 1,293.09 ± 1.10 mmol/L Trolox equivalent antioxidant capacity, while ACE-inhibitory activity was 45.68% ± 1.23%, 64.20% ± 1.24% and 82.72% ± 1.24% inhibition in 3 kDa, 5 kDa, and 10 kDa, respectively. The 10 kDa bioactive peptide exhibited superior results than the 3 kDa and 5 kDa peptides. The synbiotic mango fruit yogurt and its bioactive peptides showed significant biofunctional activities.
Innovative determination of phytohormones in Aloe vera
Authors: Hakeem Muhammad K. , Maraqa Meera , Elangovan Sampath K. , Saeed Esam Eldin , Mishra Ajay Kumar , Hazzouri Khaled M. , Shah Iltaf , Amiri Khaled M. A. 
Published: January 2025

IntroductionAloe vera is widely known for its therapeutic properties, but concerns regarding the levels of phytohormones and their potential impact on human health highlight the need for advanced analytical techniques. This study aims to develop and validate a sensitive method for the determination of six key phytohormones in Aloe vera using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).MethodsA validated LC-MS/MS method was optimized for the determination and quantification of six phytohormones in Aloe vera: Abscisic Acid (ABA), Salicylic Acid (SA), Indole-3-Acetic Acid (I3AA), Gibberellic Acid (GA), 6-Benzylaminopurine (6BAP), and Isopentenyladenine (ISA). The sample extraction process and mobile phase composition were optimized to enhance chromatographic separation and mass spectrometry sensitivity. A C-18 column was used for separation, and a triple quadrupole mass spectrometer was employed for quantification. The method’s performance was assessed in terms of linearity, sensitivity, and limits of detection.ResultsThe LC-MS/MS method exhibited excellent linearity (R2 &gt; 0.99) and low limits of detection for all six phytohormones. Four of the six analytes were identified as predominant in Aloe vera. Quantitative analysis showed that ABA was the most abundant phytohormone, with a median concentration of 8.39 ng/mL, followed by I3AA (4.32 ng/mL), SA (3.16 ng/mL), and GA (1.55 ng/mL).DiscussionThis study provides a comprehensive and validated LC-MS/MS method for profiling phytohormones in Aloe vera. The results underscore the significant role of ABA, I3AA, SA, and GA in the plant's hormonal profile, offering a valuable tool for the analysis of phytohormonal content in Aloe vera and other plant species. The method is particularly beneficial for addressing health-related concerns regarding the presence and concentration of phytohormones in Aloe vera.
Vitamin D supplementation during intensive care unit stay is associated with improved outcomes in critically Ill patients with sepsis: a cohort study
Authors: Li Caifeng , Zhao Ke , Ren Qian , Chen Lin , Zhang Ying , Wang Guolin , Xie Keliang 
Published: January 2025

BackgroundPatients with vitamin D deficiency are susceptible to increased microbial infection and increased risk of mortality. However, whether vitamin D supplementation would improve their prognosis remains uncertain.MethodsWe conducted a retrospective cohort study using data from MIMIC-IV database, a publicly available database containing clinical information on patients admitted to the ICU at Beth Israel Deaconess Medical Center (BIDMC) from 2008 to 2019. Adult patients with sepsis were included in the analysis. The exposure factor was vitamin D supplementation during the ICU stay. The primary outcome was 28-day all-cause mortality. Both propensity score matching (PSM) and stepwise regression analyses were employed to adjust for potential confounders.ResultsA total of 20230 eligible patients were enrolled in the entire unmatched cohort, and 8710 patients were included in the matched cohort. In PSM analysis, the 28-day all-cause mortality rate was 14.04% (250/1780) in the vitamin D group and 22.31% (1546/6930) in the no vitamin D group. Vitamin D supplementation was associated with decreased 28-day all-cause mortality (HR, 0.56; 95% CI, 0.49-0.64; p &lt; 0.001). Subgroup analyses showed consistent benefits regardless of the baseline vitamin D status (deficiency: HR, 0.70; 95% CI, 0.33-1.50; p = 0.36; insufficiency: HR, 0.10; 95% CI, 0.03-0.34; p &lt; 0.001; sufficiency: HR, 0.33; 95% CI, 0.12-0.88; p = 0.03). Additionally, vitamin D supplementation was associated with decreased ICU mortality (OR, 0.37; 95% CI, 0.29-0.48; p &lt; 0.001) and reduced in-hospital mortality (OR, 0.57; 95% CI, 0.48-0.68; p &lt; 0.001). Sensitivity analysis using the unmatched cohort confirmed these findings (HR, 0.57; 95% CI, 0.43-0.76; p &lt; 0.001).ConclusionsVitamin D supplementation may reduce mortality in critically ill patients with sepsis. However, further high-quality prospective studies are still needed to validate these findings.
Population genetic analysis of clinical Mycobacterium abscessus complex strains in China
Authors: Li Xiangchen , Zhu Yelei , Lu Yewei , Wu Kunyang , Che Yang , Wang Xiaomeng , Wang Weixin , Gao Junli , Gao Junshun , Liu Zhengwei , Zhou Zhuxian 
Published: January 2025

BackgroundTo explore the genetic characteristics of the Mycobacterium abscessus complex (MABC) population in China, given its rising clinical importance among nontuberculous mycobacteria.MethodsWe conducted population genetic analyses on 360 MABC genomes from China, focusing on core genome multilocus sequence typing (cgMLST), pan-genome characterization, population genetics, and antimicrobial resistance gene profiling.ResultsOur analysis identified 273 M. abscessus subsp. abscessus (MabA) and 87 M. abscessus subsp. massiliense (MabM) isolates, uncovering 68 sequence types (STs), with ST5 being the most common. cgMLST classified 33.3% of isolates into six dominant circulating clones (DCCs) and 49.4% into 59 genomic clusters at a threshold of 25 different alleles, including 18 international clusters linking Chinese isolates with seven other countries. The MABC pan-genome is open, with MabA exhibiting greater accessory gene diversity and higher gene turnover compared to MabM. Mobile genetic elements (MGEs), such as prophages and genomic islands, were prevalent across all genomes. 139 to 151 virulence factors (VFs) were identified per genome, with distinct accessory VFs in MabA and MabM affecting immune modulation and metabolism. Resistance gene profiling revealed ubiquitous mtrA, RbpA, and blaMAB, with MabA-specific erm(41) conferring resistance to macrolides and β-lactams. Common rrs and rrl gene mutations indicated widespread resistance to aminoglycosides and macrolides, while gyrA mutations suggested emerging fluoroquinolone resistance. An acquired erm(46) gene, likely obtained via phage-mediated horizontal gene transfer, was detected in one MabA strain.ConclusionThis study provides key genetic insights into the dynamics of MABC in China. The widespread distribution of DCCs, high genomic clustering rates, open pan-genome, and distinct resistance patterns between MabA and MabM, along with MGEs, highlight the need for targeted surveillance and tailored therapies to address emerging challenges in MABC infections.
Interrelation between hypoxic liver injury and Killip classification in ST-segment elevation myocardial infarction patients
Authors: Choi Seong Huan , Jang Ji-Hun , Kim Dae-Young , Suh Young Ju , Baek Yong-Soo , Shin Sung-Hee , Woo Seong-Ill , Kim Dae-Hyeok , Moon Jeonggeun , Suh Jon , Kang WoongChol , Park Sang-Don , Kwon Sung Woo 
Published: January 2025

IntroductionHypoxic liver injury (HLI) and Killip classification are poor prognostic factors in patients with ST-segment elevation myocardial infarction (STEMI). This study investigates the interrelationship between hypoxic liver injury (HLI) and Killip classification.Method and resultsA total of 1,537 STEMI patients who underwent percutaneous coronary intervention (PCI) from 2007 to 2014 at four tertiary hospitals in the Incheon-Bucheon province were enrolled in this study. The patients were divided into four groups based on their Killip classification at presentation in the emergency room (ER). HLI was defined as a ≥2-fold increase in serum aspartate transaminase (AST). The incidence of HLI showed incremental tendency with respect to the Killip classification (19.5%, 19.4%, 34.6%, and 37.8%, respectively; p &lt; 0.001). Left ventricular ejection fraction (LVEF) was below 45% in symptomatic, overt heart failure patients (Killip class II, III, and IV). Both initial and peak AST levels increased in accordance with Killip classification along with cardiac biomarkers. In-hospital mortality was directly related to Killip classification (2.3%, 7.3%, 16.3%, 29.2%) with statistical significance. Univariate and multivariate Cox regression analysis showed that the presence of HLI and combined Killip classification III and IV were poor prognostic factors, even after adjusting for conventional clinical risk factors. Receiver operating characteristic (ROC) analysis showed that combination of HLI and Killip classification was the most sensitive predictor of mortality (AUC 0.832, 95% CI 0.78–0.882). Kaplan–Meier curve showed that patients with HLI and Killip class (III and IV) had the lowest event-free survival regarding in-hospital mortality and major cardiovascular and cerebrovascular events.ConclusionsThe presence of HLI and Killip classification were directly related to worse prognosis in STEMI patients. Early recognition of HLI and accurate assessment of Killip classification is warranted for effective management of STEMI.
Motivational interviewing intervention for the management of hypertension: a meta-analysis
Authors: Xu Ju , Gu Xiaoyan , Gu Jiaying , Zhao Lijuan , Li Mianxian , Hong Cheng 
Published: January 2025

BackgroundImproving medication compliance and self-efficacy in hypertensive patients is of significant importance for their prognosis. This meta-analysis aimed to assess the role of motivational interviewing in reducing systolic and diastolic blood pressure, self-efficacy, quality of life and medication adherence in hypertensive patients.MethodsTwo authors searched PubMed, Cochrane Library, Clinicaltrials, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database, Weipu and Wanfang Database up to May 28, 2024 for randomized controlled trials (RCTs) evaluating the role of motivational interviewing on hypertensive patients. The search was restricted to articles published in English and Chinese languages. RevMan 5.4 software was used for meta-analysis.ResultsA total of 16 RCTs were included. The meta-analysis findings demonstrate that motivational interviewing could reduce both systolic pressure [MD = −3.26, 95% CI (−5.16, −1.36), P &lt; 0.001] and diastolic blood pressure [MD = −1.78, 95% CI (−3.48, −0.08), P &lt; 0.001] levels in hypertensive patients, while simultaneously enhancing their self-efficacy [MD = 2.92, 95% CI (1.84, 4.00), P = 0.001], quality of life [MD = 6.99, 95% CI (3.25, 10.74), P = 0.003], and medication compliance [OR = 4.30, 95% CI (1.53, 12.10), P = 0.003]. No significant publication bias across the synthesized outcomes were found by Egger regression analyses (all P &gt; 0.05).ConclusionsMotivational interviewing has been shown to effectively reduce blood pressure in the short term among individuals with hypertension, while simultaneously enhancing their self-efficacy, quality of life, and adherence to medication regimens.
A roadmap to implementing machine learning in healthcare: from concept to practice
Authors: Yan Adam Paul , Guo Lin Lawrence , Inoue Jiro , Arciniegas Santiago Eduardo , Vettese Emily , Wolochacz Agata , Crellin-Parsons Nicole , Purves Brandon , Wallace Steven , Patel Azaz , Roshdi Medhat , Jessa Karim , Cardiff Bren , Sung Lillian 
Published: January 2025

BackgroundThe adoption of machine learning (ML) has been slow within the healthcare setting. We launched Pediatric Real-world Evaluative Data sciences for Clinical Transformation (PREDICT) at a pediatric hospital. Its goal was to develop, deploy, evaluate and maintain clinical ML models to improve pediatric patient outcomes using electronic health records data.ObjectiveTo provide examples from the PREDICT experience illustrating how common challenges with clinical ML deployment were addressed.Materials and methodsWe present common challenges in developing and deploying models in healthcare related to the following: identify clinical scenarios, establish data infrastructure and utilization, create machine learning operations and integrate into clinical workflows.ResultsWe show examples of how these challenges were overcome and provide suggestions for pragmatic solutions while maintaining best practices.DiscussionThese approaches will require refinement over time as the number of deployments and experience increase.