bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-destructive methods applied for in situ mechanical diagnosis: Florentine historical buildings in Pietra Serena
Authors: Salvatici Teresa , Centauro Irene , Calandra Sara , Segabinazzi Eugenio , Intrieri Emanuele , Garzonio Carlo Alberto 
Published: May 2023

Abstract
Uniaxial Compressive Strength (UCS) is a key indicator of the mechanical properties of a rock, particularly in the diagnostic and restoration phases when stones are employed as construction material. In historical buildings, it is important to determine UCS values without utilizing tests that involve destructive rock sampling. To estimate UCS, non-destructive techniques, such as ultrasonic pulse velocity (Vp) and Schmidt hammer tests (R), can be combined to provide a useful tool. However, for architectural elements with complex morphology, it is sometimes impossible to perform both ultrasonic and sclerometric test. Three different UCS predictive models, one using R only, one using Vp and one using both, have been developed through regression techniques on a dataset comprising 45 Pietra Serena sandstone samples with varying levels of decay. The models were tested for their performance through Cross-Validation techniques and were then applied to a dataset of Vp and R values measured in situ on Pietra Serena corbels of balconies belonging to historical buildings in Florence (Italy). The specific predictive models were applied to real case studies, and the UCS of the rocks used in historical buildings was calculated, enabling the definition of the mechanical characteristics of building elements belonging to an important cultural context, Florentine historical architecture, without using destructive testing.
Risk factors of colorectal cancer: the comparison of selected nutritional behaviors of medical and non-medical students
Authors: Malinowska Dominika , Milewski Robert , Żendzian-Piotrowska Małgorzata 
Published: May 2023

Abstract
Background
The aim of the study was to compare the diet of medical and non-medical students in relation to colorectal cancer risk factors.

Material and methods
The study included 239 students of various universities in Bialystok, Poland. Respondents were divided into four groups: students of dietetics at the Medical University (SD), students of other fields of study at the Medical University (SMUB), students of the University of Technology (SBUT) and students of the University of Bialystok (SUB). The research tool was an anonymous questionnaire in an electronic form, designed by the authors of this paper.

Results
Overweight was the least common among students of dietetics. Products that may increase the risk of developing colorectal cancer were most frequently consumed by students of non-medical universities. Everyday consumption of processed meat products was declared by 2.08% of SD, 24.00% of SMUB, 16.13% of SBUT and 25.93% of SUB. Red meat was consumed several times a week or every day by 25% of SD, 25.33% of SMUB, 48.39% of SBUT and 35.19% of SUB. Fast-food meals consumption once or several times a week was confirmed by 4.17% of SD, 18.67% of SMUB, 27.42% of SBUT and 38.89% of SUB.

Conclusion
The study conducted shows that students expose themselves to colorectal cancer risk factors through their diet.
No predialysis treatment of blood primes in pediatric continuous kidney replacement therapy
Authors: Nagafuchi Hiroyuki , Shono Kenta , Shimizu Hiroyuki , Yamada Kaori , Kajihama Aya , Minami Sakura , Sasaki Kyosuke 
Published: May 2023

Abstract
Background
Pediatric continuous kidney replacement therapy (CKRT) uses blood as the priming fluid in the CKRT circuit to prevent hemodilution and hypotension and is dialyzed using a dialysate before the start of CKRT. This study aimed to investigate the safety of CKRT using a protocol of no predialysis after blood priming in underweight infants, based on hemodynamic and laboratory data changes.

Methods
This single-center retrospective cohort study included children weighing < 5 kg after cardiac surgery treated with CKRT from March 2019 to February 2022. Our protocol is as follows. We used 6-Fr vascular access, 20 mL priming volume of 0.3 m2 cellulose triacetate membrane, 37 mL priming volume of the pediatric extracorporeal circuit, and 57 mL of total extracorporeal volume. Heparin saline was prefilled with the extracorporeal circuit, and then, 30 mL of packed red blood cells was used to prime. Subsequently, the therapy was started without predialysis treatment of blood primes and vasopressin was used as a vasopressor for hypotension. Hemodynamic and laboratory data changes were studied.

Results
CKRT was performed in 8 patients, and 19 circuit connections were analyzed. Hypotension was observed in 10/19 (52.6%) connections, but all patients recovered within approximately 10 min. Ionized calcium, bicarbonate, and pH values were significantly decreased (p = 0.001, < 0.001, and < 0.001, respectively) before dialysis. However, 60 min after dialysis, pH recovered to predialysis levels and ionized calcium and bicarbonate recovered to > 95% of the levels before extracorporeal circulation. Moreover, potassium levels, which were not significantly different between extracorporeal circulation and dialysis initiation (p = 1.000), were significantly decreased after dialysis (p = 0.046). Lactate and hematocrit did not significantly change either before dialysis (p = 0.131 and 0.071, respectively) or after dialysis compared to the time of extracorporeal circulation (p = 1.000 and 0.591, respectively).

Conclusions
CKRT, using our protocol, could be safely performed without predialysis treatment of blood primes in children weighing < 5 kg.
Medical image classification for Alzheimer’s using a deep learning approach
Authors: Bamber Sukhvinder Singh , Vishvakarma Tanmya 
Published: May 2023

AbstractMedical image categorization is essential for a variety of medical assessments and education functions. The purpose of medical image classification is to organize medical images into useful categories for the purpose of illness diagnosis or study, making it one of the most pressing issues in the field of image recognition. On the other hand, traditional methods have plateaued in their effectiveness. Additionally, a substantial amount of time and energy is required when employing them to extract and choose categorization features. Alzheimer’s disease is one of the most frequent sources of dementia in elderly patients. Metabolic diseases affect a huge population worldwide, and henceforth, there is a vast scope of applying machine learning to find treatments to these diseases. As a relatively new machine learning technique, deep neural networks have shown great promise for a variety of categorization problems. In this research, a model for diagnosing and tracking the development of Alzheimer’s disease that is both accurate and easy to understand has been developed. By following the developed procedure, medical professionals may make deliberations with solid justification. Early diagnosis utilizing these machine learning algorithms has the potential to minimize mortality rates associated with Alzheimer’s disease. This research work has developed a convolutional neural network using a shallow convolution layer to identify Alzheimer’s disease in medical image patches. The total accuracy of proposed classifications is around 98%, which is greater than the accuracy of the most popular existing approaches.
Limited Bariatric Surgery-induced Weight Loss in Subjects With Type 2 Diabetes: Predictor Variables in Adipose Tissue
Authors: Osorio-Conles Óscar , Jiménez Amanda , Ibarzabal Ainitze , Balibrea José María , de Hollanda Ana , Vidal Josep 
Published: May 2023

Abstract

Context
The impact of type 2 diabetes mellitus (T2D) at baseline on limited weight loss (WL) after bariatric surgery (BS) remains controversial, and the potential underlying mechanisms incompletely understood.

Objective
We aimed at gaining further insight on this relationship and identifying novel associations between adipose tissue (AT) parameters and short-term WL outcomes in subjects with or without T2D undergoing BS.

Methods
Mid-term WL trajectories after BS have been evaluated in a cohort of 1659 subjects (cohort 1) with (n = 543) and without T2D (n = 1116). Paired subcutaneous and visceral AT samples were obtained from a cohort of 48 pairs of subjects with and without T2D matched for age, sex, BMI, and type of BS (cohort 2). Differences in AT parameters between groups were evaluated and potential associations with WL response explored.

Results
T2D was independently associated with a 5% lesser mid-term WL in cohort 1, while HbA1c, insulin treatment, and number of T2D medications prior to BS were only related to short-term WL outcomes. In cohort 2, a number of differentially expressed genes in AT were identified between groups, while fat cell size and fibrosis were comparable. Subcutaneous ATG7 expression was found as an independent predictor of limited WL 1 year after surgery (β: −12.21 ± 4.41, P = .008) and its addition to a clinical model significantly improved the amount of WL variability explained (R2 = 0.131 vs R2 = 0.248, F change P = .009).

Conclusion
Our results highlight the importance of T2D as determinant of limited WL following BS and suggest that dysregulated macroautophagy in subcutaneous AT may contribute to this association.
The Loneliness of the Untimely Man
Authors: Sullivan Karen 
Published: May 2023

AbstractIf solitude can be conceived as having a history, Francesco Petrarca can be said to have experienced this state in a way no thinker had done before him. In classical and late antiquity, it was a commonplace that the wise man (and he was always a man) was never less alone than when alone. Because the wise man reads books and perhaps corresponds with other writers of his day, he feels himself to be in the company of those whose works he is studying. In the Renaissance, however, the humanist feels alienated from the time period in which he is living, and he reads to place himself mentally in a time period where he will not feel so alienated. It is in this spirit that Petrarch writes his letters to Cicero and other classical authors, expressing his longing to live in the time of these kindred spirits. For Friedrich Nietzsche, it is precisely because someone like Petrarch felt himself to be so ill at ease in his own era that he was able to transform that era, reviving a culture with which he felt greater affinity. With Nietzsche, the philosopher has become the untimely man, defined by his solitude.
Designer pigs for xenogeneic heart transplantation and beyond
Authors: Wolf Eckhard , Reichart Bruno , Moretti Alessandra , Laugwitz Karl-Ludwig 
Published: May 2023

ABSTRACT
The 2-month-survival of a terminally ill patient who received a genetically modified pig heart has demonstrated that cardiac xenotransplantation could provide a therapeutic option for patients who cannot receive a human organ. Genetic engineering to overcome transplant rejection mechanisms, coagulation dysregulation and overgrowth of xeno-hearts has been the key to this success. The concept of exogenesis – the replacement of specific cellular populations and tissue structures of a pig heart with human cells – is a promising extension of xenotransplantation because it could further reduce immunological and physiological obstacles. Additionally, in the aim of preventing the need for heart transplant, tailored pig models mimicking monogenic cardiac disorders have been developed to test new cellular and molecular therapies. Thus, genetically engineered pigs provide a powerful platform for xenogeneic, exogenic and endogenic restoration of cardiac function.
Indoor environmental quality in schools: NOTECH solution vs. standard solution
Authors: Volf Carlo , Martiny Klaus , Andersen Mathias , Engberg Pallesen Bodil 
Published: May 2023

Background: In many Danish schools, the indoor environmental quality (IEQ) is challenging and studies document a poor IEQ in a majority of existing schools. Municipalities cannot afford comprehensive renovations and expensive mechanical ventilation solutions, hence public schools often suffer from poor indoor environment conditions. This study tests a new façade based, demand-controlled ventilation solution called NOTECH in the renovation of school. The study tests NOTECH vs. existing mechanical ventilation solution, comparing performance of both solutions at Skovbrynet Skole in Denmark. Methods: The project implements and investigates the effect of the NOTECH solution in a primary school classroom, comparing it to a similar classroom with conventional, mechanical ventilation. Methodically, indoor environmental quality and energy performance is monitored in the two identical classrooms during one school year 2018 - 2019. Results: The results show that both systems keep the conditions within acceptable limits and CO2 levels below 1000 ppm, which is the requirement according to the Danish Building Regulations. In terms of costs, the NOTECH system has a lower overall cost than the mechanical ventilation system, with total estimated costs for installation, heating, electricity and maintenance amounting to approximately 35% of the mechanical system’s costs. Finally, the results show that the NOTECH solution has a smaller embedded CO2 footprint for building materials, reducing the estimated carbon load by 95% compared to the mechanical ventilation solution. Conclusions: The performance of the two systems roughly is the same in relation to the indoor environmental quality, temperature, CO2 levels, humidity and noise level. Costs for implementation, energy consumption for heating and CO2 footprint for building materials however, are significantly lower for the NOTECH solution, compared to the mechanical solution.
Whole body vibration and rider comfort determination of an electric two-wheeler test rig
Authors: Krishna Keerthan , Hegde Sriharsha , G T Mahesha , Shenoy B Satish 
Published: May 2023

Background: Two-wheeled vehicles are the major mode of transportation in India. Such vehicles are exposed to excessive vibration on the road when compared to four-wheeled vehicles. However, the research on the reduction of whole body vibration in the case of two-wheelers is not explored in detail. The present study predicts rider comfort in the case of an electric two-wheeler as per ISO 2631-1. Methods: An electric two-wheeler test rig is used in the study. The values of acceleration from the test rig in running conditions are obtained by using NI LabVIEW 2016. The drive cycle of the electric vehicle (EV) test rig is controlled by Sync sols’ EV lab software. Obtaining the root mean square (RMS) acceleration from running the test setup, it is compared with the ISO 2631 standard to obtain the rider comfort. Results: Loading area, traction motor, base mount, and suspension were found to be the strategic points of vibration. RMS acceleration of 0.2 g to 3.29 g obtained at these points are prone to cause discomfort for the rider. Vehicle speed, road profile, and duration of exposure were found to be important parameters affecting the rider’s comfort. About 19 % increase in the vibration amplitude is observed at the loading area when loads are removed. The loading area as corresponds to a rider’s seat in actual vehicle, it is important to reduce these vibrations to make the ride comfortable for the rider. Conclusions: A suitable damping technique design is very much essential in reducing these vibrations and improve the rider comfort, as many more non-deterministic vibrations are prone to cause dis-comfort in case of actual on road riding conditions.
Case Report: Case report: An unusual presentation of granulomatosis with polyangiitis
Authors: Bannour Ichrak , Ben Brahim Maroi , Arfa Sondes , Amor Soumaya ben , Ben Mabrouk Asma , Berrich Olfa , Hammemi Sonia 
Published: May 2023

Aim: We are reporting a case of an unusual presentation of granulomatosis with polyangiitis (GPA) with liver involvement. Case presentation: A 45-year-old male patient presented with erythematous plaques on the face and bilateral nasal obstruction. On physical examination, the patient had a ring-shaped squamous plaque on the face. The laboratory findings revealed an accelerated erythrocyte sedimentation rate at 100 mm/h, an elevated C-reactive protein at 66 mg/L, hyper gamma globulinemia 16 g/L and an elevated alkaline phosphatase (twice the upper normal limit). The craniofacial and thoracoabdominal computed tomography (CT) -scans showed ethmoid and maxillary sinusitis, low facial bone density, multiple mediastinal and hilar lymphadenopathy, diffuse small pulmonary nodules, and hepatomegaly. A cutaneous lesion biopsy, the nasal mucosa, and the liver showed a chronic inflammatory granulomatosis process with necrosis. Serum anti-neutrophil cytoplasmic antibody (ANCA) against PR3 was positive. The clinical, biological, radiological, and histological findings substantiated the diagnosis of GPA. The patient received systemic steroids combined with cyclophosphamide pulses on days 1, 14 and 28 and then he was lost to follow-up. Two-years later, he presented with a cardiac failure and skin ulcer in the right lower limb. A nasal endoscopic exam showed nasal septum cartilage perforation with resorption of the middle and inferior nasal concha. Two weeks later, he developed a diffuse alveolar hemorrhage and was therefore transferred to the intensive care unit but died of respiratory failure 3 days later. Conclusion: Clinicians should be aware of GPA atypical clinical manifestations.
On dominions of certain ample monoids
Authors: Sohail Nasir , Umar Abdullahi 
Published: May 2023

A semigroup S is called left ample if it can be embedded in the symmetric inverse semigroup IX of partial bijections of a non-empty set X such that the image of S is closed under the unary operation α → αα⁻¹, where α⁻¹ is the inverse of α in IX. Right ample semigroups are defined dually. A semigroup is called ample if it is both left and right ample. A monoid is (left, right) ample if it is (left, right) ample as a semigroup. We observe that the dominion of an ample subsemigroup of IX coincides with the inverse subsemigroup of IX generated by it. We then determine the dominions of certain submonoids of In, the symmetric inverse semigroup over a finite chain 1<2<⋯<n.
Further remarks on permissible covariance structures for simultaneous retention of BLUEs in linear models
Authors: Puntanen Simo , Haslett Stephen , Isotalo Jarkko , Markiewicz Augustyn 
Published: May 2023

We consider the partitioned linear model M12(V0) = { y, X1β1 + X2 β2, V0 } and the corresponding small model M1(V0) = { y, X1β1 , V0 } . We define the set V1/12 of nonnegative definite matrices V such that every representation of the best linear unbiased estimator, BLUE, of μ1 = X1β1 under M12(V0) remains BLUE under M12(V) . Correspondingly, we can characterize the set V1 of matrices V such that every BLUE of μ1 = X1β1 under M1(V0) remains BLUE under M1(V). In this paper we focus on the mutual relations between the sets V1 and V1/12 .
Psychological burden and disease-related quality of life in dialysis patients during the first wave of the COVID-19 pandemic — a cross-sectional observational study
Authors: Pawłowski Marcin , Fila-Witecka Karolina , Rymaszewska Marta , Zielińska Dorota , Kłak Renata , Krajewska Magdalena , Rymaszewska Joanna 
Published: May 2023

Cel pracyW niniejszym badaniu staraliśmy się odpowiedzieć na pytanie, czy poziom odczuwanego stresu związanego z pandemią wpływa na jakość życia związaną z chorobą i funkcjonowanie pacjentów dializowanych otrzewnowo i hemodializowanych.MetodaSpośród 106 chorych leczonych w stacji dializ Uniwersyteckiego Szpitala Klinicznego podczas pierwszej fali pandemii, zrekrutowano finalnie 73 pacjentów, w tym 61 hemodializowanych (HD) i 12 diali-zowanych otrzewnowo (PD). Do badania zastosowano Skalę Postrzeganego Stresu (The Perceived Stress Scale-PSS), Ogólny Kwestionariusz Zdrowia (The General Health Questionnaire-GHQ-28), Zrewidowaną Skalę Wpływu Zdarzeń (The Impact of Events Scale Revised-IES-R), oraz The Kidney Disease and Quality of Life (KDQOL-SF™).WynikiBlisko połowa respondentów (48%) doświadczała dystresu psychologicznego a 5,6% badanych wykazywało klinicznie istotne objawy psychopatologiczne (GHQ). Połowa grupy badanej deklarowała znaczące wystę-powanie objawów stresu pourazowego (IES-R). Obserwowano wysoki wynik subiektywnie postrzeganego stresu związanego z pandemią w obu grupach badanych. Stwierdzono liczne istotne ujemne korelacje po-między wynikami podskal KDQoL a objawami psychopatologicznymi (IES-R i GHQ) bez istotnych różnic pomiędzy obiema grupami (HD vs PD). Niemal wszystkie podskale KDQoL były istotnie umiarkowanie lub silnie skorelowane z poziomem odczuwanego stresu związanego z pandemią.WnioskiPoziom subiektywnie ocenianego stresu związanego z pandemią, nasilenie objawów psychopatologicznych, w tym stresu pourazowego były znaczące w całej grupie pacjentów poddanych terapii nerkozastępczej, nieza-leżnie od rodzaju dializ. Potwierdzone liczne związki pomiędzy domenami jakości życia związanej z chorobą a poziomem odczuwanego stresu i objawami psychopatologicznymi wskazują na pilną potrzebę dostarczania skutecznego wsparcia psychologicznego tej grupie chorych oraz opracowania programów prewencyjnych w zakresie zdrowia psychicznego osób poddanych terapii nerkozastępczej.
Supplementation of evening primrose oil (EPO) - benefits and limitations. Results of the latest studies
Authors: Grosman Sylwia , Winiarz Aleksandra , Wąsala Katarzyna , Wokurka Wojciech , Turek Michał , Szlendak Paula , Toś Katarzyna , Wojtala Kacper , Węgrzyniak Agata , Drobek Dominik 
Published: May 2023

Introduction
One of the most frequently used herbal drugs in the pharmaceutical industry is Oenothera biennis, traditionally called evening primrose. Oil extracted from seeds of a plant is a rich source of unsaturated fatty acids- omega 6 essential fatty acids (EFAs). Healing properties of evening primrose oil (EPO) have been used for ages in order to alleviate symptoms of various medical conditions. Nowadays, studies and clinical trials are conducted with the aim of verifying its effectiveness.
The aim of the study
Summarize current knowledge on the effectiveness of evening primrose oil in treatments of various diseases.
Material and methods
The search of the Pubmed database was carried out using keywords, in order to find the latest publications.
Summary
Despite limitations, research shows that supplements containing evening primrose oil (EPO) demonstrate promising results in treatments of various medical conditions, including menopause, premenstrual syndrome, skin problems or multiple sclerosis. However, more well-designed clinical trials are needed to evaluate long-term effectiveness.