bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Radioactive Iodine (131I) Therapy among Hyperthyroid patients
Authors: Sajjad Ali Khan Muhammad , Hussain Arshad , Ahmad Shahzad , Shah Muhammad Harris 
Published: September 2023

Objective: The present study aimed to assess the thyroid outcomes six-months after radioactive Iodine-131 therapy (RIT) among hyperthyroid patients and identify the factors associated with them.
Methods: This retrospective observational study was conducted at the department of Nuclear Medicine and Molecular Imaging, Northwest General Hospital & Research Centre during 2013 to 2019. For the study purpose, the thyroid outcomes of 153 hyperthyroid patients were studied retrospectively for six months after RIT. The data was obtained from the medical records. Patient baseline characteristics, clinical features, laboratory investigations, results of thyroid imaging, and therapeutic investigations were acquired and recorded in a structured questionnaire.
Results: Out of the 153 screened records of hyperthyroid patients, 19.6% became euthyroid, 9.2% remained hyperthyroid, and 25.5% developed hypothyroidism after six months of RIT. The observed remission rate by the end of six months was 80.95%. Three months post-RIT, gender and RAI doses had a significant effect on thyroid function. The frequency of hypothyroidism was higher among those treated with an RAI dose of ≤ 20 mCi (83.0%) than those treated with a higher dose > 20 mCi (17%). Moreover, most patients receiving > 20 mCi radioiodine became euthyroid (64.5%). Similar outcomes were observed after six months of the therapy, except gender was replaced by etiologies of hyperthyroidism (p=0.009).
Conclusion: Radioactive iodine (131-I) therapy is effective for the treatment of hyperthyroidism. However, the appropriate dose is still debatable, as there was a high incidence of hypothyroidism post-therapy.
doi: https://doi.org/10.12669/pjms.39.6.7567
How to cite this: Khan MSA, Hussain A, Ahmad S, Shah MH. Outcomes of Radioactive Iodine (131I) Therapy among Hyperthyroid patients. Pak J Med Sci. 2023;39(6):---------. doi: https://doi.org/10.12669/pjms.39.6.7567
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Hashimoto's disease - the role of factors and diet in the course of the disease
Authors: Gąbka Ilona , Dalmata Weronika , Gendek Karolina , Dąbrowski Jan , Kozłowska Anna , Korzeniowska Anna , Załęska Natalia , Ziółkiewicz Aleksandra 
Published: September 2023

Introduction: Hashimoto's disease is an autoimmune disorder that develops as a result of a pathological reaction of the patient's immune system, which consequently destroys the body's own healthy cells and tissues. Genetic, environmental and immunological factors influence its development. The disease may initially be asymptomatic. The exact aetiology of the disease is unknown. The worldwide incidence is approximately 10-12%.
Purpose: This paper aims to present the influence of genetic factors, environmental factors, trace elements, and diet on the development and course of Hashimoto's disease based on the current state of knowledge.
Conclusions: Hashimoto's disease is a multifactorial disease, but the relevance of all factors presented in the development and progression has not yet been confirmed. To date, a special diet for patients has not been created. Further research is needed to better understand the pathogenesis of the disease in order to help patients control HT.
Methods: Data for the article were retrieved using PubMed setting the time descriptors to 2013-2023.
Quantification of cardiac pumping mechanics in TAVI patients: A pilot study utilizing minimally invasive method for pressure‐volume analysis
Authors: Ko Tsung‐Yu , Chuang Chia‐Chuan , Lin Mao‐Shin , Chen Yi‐Chang , Chen Ying‐Hsien , Huang Ching‐Chang , Yeh Chih‐Fan , Wang Ming‐Jiuh , Chang Kuo‐Chu , Ho Yi‐Lwun , Kao Hsien‐Li 
Published: September 2023

AbstractThe ventriculo‐arterial coupling (VAC) and left ventricle (LV) mechanics are crucial and play an important role in the pathophysiology of aortic stenosis (AS). The pressure‐volume (PV) analysis is a powerful tool to study VAC and LV mechanics. We proposed a novel minimally‐invasive method for PV analysis in patients with severe AS receiving transcatheter aortic valve implantation (TAVI). Patients with severe AS were prospectively enrolled in a single center. LV pressure and cardiac output were recorded before and after TAVI. We constructed the PV loop for analysis by analyzing LV pressure and the assumed flow. 26 patients were included for final analysis. The effective arterial elastance (Ea) decreased after TAVI (3.7 ± 1.3 vs. 2.9 ± 1.1 mmHg/mL, p < 0.0001). The LV end‐systolic elastance (Ees) did not change immediately after TAVI (2.4 ± 1.3 vs. 2.6 ± 1.1 mmHg/mL, p = 0.3670). The Ea/Ees improved after TAVI (1.8 ± 0.8 vs. 1.2 ± 0.4, p < 0.0001), demonstrating an immediate improvement of VAC. The stroke work (SW) did not change (7669.6 ± 1913.8 vs. 7626.2 ± 2546.9, p = 0.9330), but the pressure‐volume area (PVA) decreased (14469.0 ± 4974.1 vs. 12177.4 ± 4499.9, p = 0.0374) after TAVI. The SW/PVA increased after TAVI (0.55 ± 0.12 vs. 0.63 ± 0.08, p < 0.0001) representing an improvement of LV efficiency. We proposed a novel minimally invasive method for PV analysis in patients with severe AS receiving TAVI. The VAC and LV efficiency improved immediately after TAVI.
Gordon Matta-Clark: de la Idea como Modelo al Ejemplo como Práctica
Authors: Salas Lamamié de Clairac Ramón 
Published: September 2023

Gordon Matta Clark, uno de los artistas visuales más influyentes del siglo pasado, era arquitecto. No obstante, desde el mismo momento de su graduación manifestó claras discrepancias con sus colegas. Su legendaria “participación” en la exposición Idea as model ilustra a la perfección no solo el espíritu radicalmente renovador del arte de la década de los 70 sino el tránsito del paradigma modernista al posmoderno. A partir de la deconstrucción del título de aquella muestra en el IAUS, este artículo analiza las múltiples y variadas estrategias de la obra de Matta Clark para horadar la epidermis arquitectónica como ejemplo de la evolución estética desde el idealismo autónomo y el ensimismamiento disciplinar hacia el arte contextual y transdisciplinar. Matta-Clark, menos preocupado por tener ideas que por dar ejemplo, parece entender el posmodernismo desde un punto de vista muy alejado de Scott Brown, Venturi o Moore, pero también de Judd o Serra. Su obra interpreta la crisis del modernismo y la especificidad para el lugar como una exhortación a la arquitectura –y al arte en general– a adquirir una mayor sensibilidad hacia los procesos de transformación social y urbana que se estaban viviendo en el tránsito del fordismo al posfordismo.
A Lack of Joi: Hegemonic Femininity and the Male Gaze in Blade Runner: 2049
Authors: McCann Ashley , Engstrom Erika 
Published: September 2023

ABSTRACTThis article examines how the 2017 film Blade Runner: 2049 reinforces a patriarchal viewpoint utilizing hegemonic femininity and the male gaze as theoretical approaches. The holographic character Joi's appearance and interactions with the male protagonist K reflects hegemonic femininity, which adds to how the film's women characters reaffirm the centrality of K and gender stereotypes that prevent this sequel from reflecting any expected progress since the release of the original Blade Runner in 1982.
Black Parallax: Hollywood's Recent Approach to Mitigating Racial Excess
Authors: Cosey Felicia 
Published: September 2023

ABSTRACTThis paper argues that from 2013 to 2021 Hollywood filmmakers have favored casting Black British actors to play Black American characters in dramas dealing with racism and oppression in the US in order to remove the racial excess associated with Black American subjects. Once excess is removed, filmmakers feel free to craft narratives that appeal to US moviegoers and that elide the national shame of the enslavement and persecution of descendants of American slaves.
CREATIVITY AND ITS ASSOCIATION WITH MINDFULNESS, EMOTIONS REGULATION, AND PSYCHOLOGICAL WELL-BEING IN ADOLESCENTS
Authors: Salam Abdus , Khalily Muhammad Tahir 
Published: September 2023

Purpose of the study: This study aims to investigate the relationship of creativity to mindfulness, emotion regulation, and psychological well-being among adolescents.
Methodology: The cross-sectional and correlational study used purposive convenient sampling, and collected data from 600 adolescents aged 15 to 24. The data collection was conducted in colleges and universities using English as the medium of instruction. For this purpose, the scales used were the Kaufman Domains of Creativity scale (Kaufman, 2012), the Mindfulness Attention Awareness Scale (Brown & Ryan, 2003), the Emotion regulation questionnaire (Gross & John, 2003), and Ryff Psychological Wellbeing (Ryff et al., 2007). Data was analyzed using SPSS-26.
Main Findings: The study found that creativity is not related to any other variable. However, mindfulness is positively linked to emotion regulation and psychological well-being, and emotion regulation is positively linked to psychological well-being. There were significant gender differences in creativity and emotion regulation, with males scoring higher, but no significant gender differences in mindfulness and psychological well-being.
Applications of the study: This study on adolescents' creativity and its relationship with mindfulness, emotion regulation, and psychological well-being has applications in education, mental health interventions, parenting, youth development, policy, and further research. It can inform interventions, programs, and policies aimed at fostering creativity, promoting well-being, and supporting adolescent development.
Novelty/Originality of the study: This study investigates the relationship between creativity, mindfulness, emotional regulation, and psychological well-being in adolescents. It focuses on the inherent traits of mindfulness and explores the benefits of instant creativity, specifically divergent thinking. The study aims to understand how everyday creativity relates to mindfulness, emotional regulation, and well-being, with a focus on gender differences. The findings could contribute to promoting well-being and creativity in adolescents.
The relationship between quality of life and dietary fluid restriction non-adherence in hemodialysis patient
Authors: Yılmaz Eda Nur , Bal Cansev , Harbali Sevil Masat , Sağlam Zeynep , Koç Zelih 
Published: September 2023

Hemodialysis is now the preferred method in the treatment of kidney failure. Patients who do not adhere to the diet during hemodialysis may experience negative changes in fluid-electrolyte balance. This study aimed to investigate the relationship between restricted fluid intake and the quality of life of hemodialysis patients in our country. The study was conducted with 186 hemodialysis patients, treated as outpatients in the hemodialysis unit of a university hospital in Samsun and as inpatients in the nephrology clinic. Data were collected using a questionnaire that included 23 questions on patients' sociodemographic and clinical characteristics, the SF-36 Short Quality of Life Scale, and the Dialysis Diet and Fluid Restriction Nonadherence Questionnaire. Kruskal-Wallis and Mann-Whitney U tests were used for analysis of quantitative data while Spearman correlation coefficient was used for correlation analysis. In line with the evidence obtained, it was established that there was a negative correlation between the status of non-compliance to dialysis diet and fluid restriction and the quality of life of individuals on hemodialysis treatment.
Keywords: Diet; hemodialysis; fluid restriction; quality of life.
Determining the use of herbal treatment by dermatology patients
Authors: Baş Zeynep , Çamlıca Tuğçe , Koç Zeliha 
Published: September 2023

This descriptive study was conducted to determine the use of herbal treatment by dermatology patients. The study involved 146 patients who were treated in the dermatology department of a university hospital between 26/11/2017 and 26/05/2018 and agreed to participate in the study. Data were collected using a 29-question information questionnaire prepared by the researchers based on the literature. In addition, a list of plants was given to the patients in the appendix of the information sheet. The Mann-Whitney U test and the Kruskal-Walli’s test were used to compare the data. The Pearson Chi-square test was used to analyze the relationship between the variables. The present study found that the majority of patients were satisfied with the medical treatment they received. It was found that patients who use complementary alternative methods in addition to medical treatment told health professionals about their current situation or felt that information should be given.
Keywords: Dermatology; herbal; nurses; therapy
Real-world multidisciplinary outcomes of onasemnogene abeparvovec monotherapy in patients with spinal muscular atrophy type 1: experience of the French cohort in the three first years of treatment.
Authors: DESGUERRE Isabelle , BARROIS Rémi , AUDIC Frédérique , BARNERIAS Christine , CHABROL Brigitte , DAVION Jean-Baptiste , DURIGNEUX Julien , ESPIL-TARIS Caroline , BANDA Marta GOMEZ-GARCIA DE LA , GUICHARD Marine , ISAPOF Arnaud , NOUGUES Marie-Christine , LAUGEL Vincent , GOFF Laure LE , MERCIER Sandra , PERVILLE Anne , RICHELME Christian , THIBAUD Marie , SARRET Catherine , SCHWEITZER Cyril , TESTARD Hervé , TROMMSDORFF Valérie , VANHULLE Catherine , WALTHER-LOUVIER Ulrike , ALTAZURRA Cecilia , CHOUCHANE Mondher , ROPARS Juliette , QUIJANO-ROY Susana , CANCES Claude 
Published: September 2023

Abstract

Background: Spinal muscular atrophy type 1 (SMA1) is the most severe and early form of SMA, a genetic disease with motor neuron degeneration. Onasemnogene abeparvovec gene therapy (GT) has changed SMA1’s natural history, but real-world data is scarce.
Methods: A French national expert committee identified 95 newly diagnosed and treatment-naive SMA1 cases between June 2019 and June 2022, all genetically confirmed. A multicentric national-wide study was performed in those children treated by GT as first-line for more than one year-time, with particular focus in their motor, nutritional and respiratory outcomes, as well as their clinical complications and management (i.e.spinal bracing, enteral and respiratory support requirements) assessed at baseline and every 6 months after GT.
Results: Forty six SMA1 patients received GT.Twelve patients received other treatments. Patients with respiratory insufficiency were oriented toward palliative care after discussion with families. Among treated patients, 29 with more than 12 months follow-up were included in the follow-up analysis. Mean age at treatment was 7.5 (2.1 - 12.5). Twenty-two patients had two SMN2copies, 7 had three. The clinical phenotype was SMA1a (n=3), SMA1b (n=15) and SMA1c (n=11). Two infants died in the months following GT due to severe thrombotic microangiopathy and respiratory distress respectively. Among patients with 24 months follow-up (N=17), 90% of them required spinal bracing (15/17) due to axial hypotonia or scoliosis. Three required nocturnal non-invasive ventilation and two gastrostomy. Concerning motor milestones at 24 months follow-up, all patients acquired head holding, 15/17 sited 30 seconds unassisted, and 12/17 could stand with aid. Motor scores (CHOPINTEND and HINE-2) and thoracic circumference significantly improved in all cases.
Conclusions: Our study shows favourable motor, respiratory and feeding real-world outcomes with GT as first line in most SMA1 infants treated before respiratory and bulbar dysfunction occur, although almost all develop spinal deformities.
Clinical and biochemical characteristics of schizophrenia patients with and without COVID-19: A retrospective study
Authors: Zhang Qiao , Liu Farong , Shi Lei , Dai Huirong , Bai Yixuan , You Pan 
Published: September 2023

Abstract
Background
Previous studies have shown that patients with mental diseases such as schizophrenia are at high risk of coronavirus disease 2019 (COVID-19). However, the clinical characteristics of patients with schizophrenia and COVID-19 remain unknown. The aim of this study was to investigate the differences in clinical biochemical values between schizophrenia patients with and without COVID-19.
Methods
We undertook an exploratory, retrospective review of patient data from Dec. 6, 2022, to Jan. 31, 2023. A total of 1696 inpatients with psychosis (921 schizophrenia patients and 775 diagnosed with other mental diseases) during this period were identified. Finally, 60 schizophrenia patients were enrolled in our study, and 20 of them were infected with syndrome coronavirus 2 (SARS-CoV-2).
Results
The serum biochemical levels, blood cell counts and single-cell mitochondrial mass (SCMM) of the T lymphocytes of all schizophrenia patients were analyzed. Schizophrenia patients with COVID-19 (SCZ-C) showed higher serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatinine (Cr), uric acid (UA), lactate dehydrogenase (LDH), myoglobin (Myo), and C-reactive protein (CRP) and platelet counts and a significant decrease in lymphocyte, monocyte, eosinophil, and basophil cell counts. In addition, positive correlations were found between the T-cell subpopulation counts and positive symptom scores on the Positive and Negative Syndrome Scale (PANSS).
Conclusion
Our study findings showed that schizophrenia patients with COVID-19 have a phenotype of mitochondrial damage in peripheral blood T lymphocytes and may have liver, heart and kidney damage compared with SARS-CoV-2-negative schizophrenia patients.
Incidence of hyperkalemia in patients on maintenance hemodialysis and risk-factor analysis
Authors: Xie Chao , Kong Yaozhong , Liang Min , Liu Xiaoyi , Ye Peiyi , Zhang Ze , Mai Haoran 
Published: September 2023

Abstract
Objective: For patients on maintenance hemodialysis, hyperkalemia has now been
lowered from 5.5 mmol/L to 5.0 mmol/L. We undertook this study in order to clarify the incidence of hyperkalemia under this new criterion, to determine the associated risk factors, and to provide guidance for the prevention of hyperkalemia.
Methods: Data from all hemodialysis centers of Foshan City were included in a crosssectional survey, the overall incidence of hyperkalemia was determined and the risk factors were analyzed.
Results: Our study comprised 2582 patients from 34 dialysis centers. 107 patients (4.14%) with serum potassium levels at or below 3.5 mmol/L, 1473(57.05%) with serum potassium levels between 3.5 and 5.0 mmol/L, 494 (19.13%) with serum potassium levels between 5.0 and 5.5 mmol/L, and 508 (19.67%) with serum potassium levels above 5.5 mmol/L. The Incidence of hyperkalemia was significantly greater under the new criterion than the old criterion (38.81% vs 19.67%, P <0.001).
We divided the patients into non-hyperkalemia and hyperkalemia groups by the new criterion. Patients in the hyperkalemia group were younger, higher body-mass indices (BMIs), higher systolic and diastolic blood pressures, higher serum creatinine, higher serum blood urea nitrogen (BUN), lower pre-dialysis carbon dioxide combining power (CO2CP), and less residual urine volume(RUV), higher proportion of using angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs). Through multiple logistic regression analysis, we found that systolic blood pressure, RUV, ACEI/ARB usage, pre-dialysis CO2CP, and pre-dialysis BUN were independent risk factors for hyperkalemia.
Conclusion: In the Foshan area, the incidence of hyperkalemia in patients on maintenance hemodialysis is very high. Under the new criterion, the diagnosis rate of hyperkalemia would be significantly increased. Moreover, high systolic blood pressure,decreased RUV, decreased pre-dialysis CO2CP, increased pre-dialysis BUN, and the use of ACEIs/ARBs were found to be independent risk factors for hyperkalemia.
Recruiting students to rural Longitudinal Integrated Clerkships: A qualitative study of medical educationists’ experiences across continents
Authors: Pinidiyapathirage Janani , Heffernan Robert , Carrigan Brendan , Walters Sherrilyn , Fuller Lara , Brumpton Kay 
Published: September 2023

Abstract

Introduction Many health systems struggle in the provision of a sustainable and an efficient rural health workforce. There is evidence to suggest that Longitudinal Integrated Clerkships (LIC) placing student learners in rural community settings have positively impacted the provision of rural health care services The recruitment and engagement of students in rural LIC have significant challenges. This study explored best practice methods of recruiting and supporting the transition of medical students into rural LIC. Methods The study took place during the 2021 Consortium of Longitudinal Integrated Clerkships Conference, a virtual event hosted by Stellenbosch University, South Africa. Participants consisted of delegates attending the Personally Arranged Learning Session (PeArLS) themed ‘Secrets to success’. The session was recorded with the participants’ consent and the recordings were transcribed verbatim. Data was uploaded to NVivo software and coded and analyzed using constant comparative analysis. Salient themes and patterns were identified. Results Thirteen attendees participated in the PeArLS representing a range of countries and institutions. Strategically marketing the LIC brand, improving the LIC program profile within institutions by bridging logistics, and the need to scaffold the transition to the rural LIC learning environment emerged as key themes for success. The attendees highlighted their experiences using peer groups, early exposure to rural LIC sites, and student allocation strategies for promotion. Unique learning styles adopted in LIC models, student anxiety and the importance of fostering supportive relationships with stakeholders to support students in their transition to the LIC environment were discussed. Discussion This PeArLS highlighted successful systems and processes implemented in rural settings across different countries to recruit and manage the transition of medical students to rural LICs. The process proved to be a quick and efficient way to elicit rich information and may be of benefit to educationists seeking to establish similar programs or improve existing rural LIC programs.