bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overview of Section XI Stipulations
Authors: Park Gary , Scarth Douglas 
Published: June 2023

Abstract
This chapter provides a chronological overview of the development of Section XI, “The Rules for Inservice Inspection of Nuclear Power Plant Components,” from its 1968 inception to the 2019 edition. It traces the development, edition-by-edition, of important Code elements including the philosophy behind many of the revisions. Emphasis is placed on the 2003 Addenda through 2008 Addenda because they apply to a majority of nuclear plants in the United States and in other countries. Through an extensive tabulation of Code Interpretations, this chapter also attempts to give the Code user some insights into clarification of many Section XI requirements. Further insight into the philosophy and technical basis behind Section XI may be gained from review of papers cited in the Bibliography of this chapter.
Subsequent chapters of this book address the major areas of Section XI, including inservice inspection (ISI) examination and test programs, repairs and replacements, acceptance and evaluation criteria, containment programs, and fatigue crack growth. Reference to specific chapters is included as changes to their topics are introduced. Their specific discussions may be easier to follow and will be more complete than the brief chronological development in this chapter. Nondestructive examination is addressed in this chapter as its requirements evolve.
The 2017 and 2019 Editions of the Code provides the basis for changes and additions to this Chapter.

History
The current online edition was updated by Gary Park and Douglas Scarth
Inferring microbial co-occurrence networks from amplicon data: a systematic evaluation
Authors: Kishore Dileep , Birzu Gabriel , Hu Zhenjun , DeLisi Charles , Korolev Kirill S. , Segrè Daniel 
Published: June 2023

ABSTRACT

Microbes commonly organize into communities consisting of hundreds of species involved in complex interactions with each other. 16S ribosomal RNA (16S rRNA) amplicon profiling provides snapshots that reveal the phylogenies and abundance profiles of these microbial communities. These snapshots, when collected from multiple samples, can reveal the co-occurrence of microbes, providing a glimpse into the network of associations in these communities. However, the inference of networks from 16S data involves numerous steps, each requiring specific tools and parameter choices. Moreover, the extent to which these steps affect the final network is still unclear. In this study, we perform a meticulous analysis of each step of a pipeline that can convert 16S sequencing data into a network of microbial associations. Through this process, we map how different choices of algorithms and parameters affect the co-occurrence network and identify the steps that contribute substantially to the variance. We further determine the tools and parameters that generate robust co-occurrence networks and develop consensus network algorithms based on benchmarks with mock and synthetic data sets. The Microbial Co-occurrence Network Explorer, or MiCoNE (available at
https://github.com/segrelab/MiCoNE
) follows these default tools and parameters and can help explore the outcome of these combinations of choices on the inferred networks. We envisage that this pipeline could be used for integrating multiple data sets and generating comparative analyses and consensus networks that can guide our understanding of microbial community assembly in different biomes.

IMPORTANCE
Mapping the interrelationships between different species in a microbial community is important for understanding and controlling their structure and function. The surge in the high-throughput sequencing of microbial communities has led to the creation of thousands of data sets containing information about microbial abundances. These abundances can be transformed into co-occurrence networks, providing a glimpse into the associations within microbiomes. However, processing these data sets to obtain co-occurrence information relies on several complex steps, each of which involves numerous choices of tools and corresponding parameters. These multiple options pose questions about the robustness and uniqueness of the inferred networks. In this study, we address this workflow and provide a systematic analysis of how these choices of tools affect the final network and guidelines on appropriate tool selection for a particular data set. We also develop a consensus network algorithm that helps generate more robust co-occurrence networks based on benchmark synthetic data sets.
Study of the Polymorphism of ISSR Markers in Spined Loaches of the Genus Cobitis (Cobitidae) in Connection with Problems of Differentiation of the Species Involved in the Formation of Polyploid Forms of Hybrid Origin and Determination of Their Taxonomic Status
Authors: Volkov A. A. , Rastorguev S. M. , Vasil’eva E. D. , Vasil’ev V. P. 
Published: June 2023

Abstract
We have analyzed the polymorphism of ISSR fragments of DNA by polymerase chain reaction in spined loaches for the first time. The analysis has made it possible to successfully differentiate the genomes, which were presumably involved in the formation of polyploid forms of hybrid origin: Cobitis taenia; spined loaches from the Danube River basin, which are diagnosed as C. elongatoides; C. tanaitica from the Don River basin and spined loaches from Lake Sinoe, which are also assigned to the species C. tanaitica by a number of authors. The following conclusions have been made based on comparative morphological studies of previously undifferentiated forms: (1) spined loaches from Central Europe with karyotype 2n = 50, NF = 96 correspond to the diagnosis of the species C. elongatoides; this species also differs from a number of closely related species and polyploid forms in the origin of the dorsal fin in front of the base of the pelvic fins, as well as in the presence of a spot in the lower half of the caudal fin base; (2) spined loaches from Lake Sinoe and other populations of Central Europe with karyotype 2n = 50, NF = 86 are nonconspecific to C. tanaitica and should apparently be ranked as an independent species, C. megaspila.
Effectiveness of internet-based and mobile-based interventions for adults with overweight or obesity experiencing symptoms of depression: a systematic review protocol
Authors: Schladitz Katja , Luppa Melanie , Riedel-Heller Steffi G , Loebner Margrit 
Published: June 2023

IntroductionInternet-based and mobile-based interventions (IMIs) provide innovative low-threshold and cost-effective prevention and self-management options for mental health problems complementary to standard treatment. The objective of this systematic review is to summarise the effectiveness and to critically evaluate studies on IMIs addressing comorbid depressive symptoms in adults with overweight or obesity.Methods and analysisThe study authors will systematically search the databases MEDLINE, Cochrane Library, PsycINFO, Web of Science, Embase and Google Scholar (for grey literature) for randomised controlled trials (RCTs) of IMIs for individuals with overweight or obesity and comorbid depressive symptoms without restrictions on publication date (planned inception 1 June 2023 to 1 December 2023). Two reviewers will independently extract and evaluate data from studies eligible for inclusion by assessing quality of evidence and qualitatively synthesising results. Preferred Reporting Items for Systematic reviews Meta-Analyses (PRISMA) standards and the revised Cochrane Risk of Bias tool in RCTs (RoB 2) will be applied.Ethics and disseminationEthical approval is not required as no primary data will be collected. Study results will be disseminated through publication in a peer-reviewed journal and presentations on conferences.PROSPERO registration numberCRD42023361771.
Cardiovascular disease risk among hypertensive patients and associated determinants in Addis Ababa, Ethiopia: an institutional-based cross-sectional study
Authors: Getahun Genanew Kassie , Goshu Bizunesh Yadeta , Goshu Dejuma Yadeta , Mekuria Zelalem Negash 
Published: June 2023

ObjectiveThe aim of this study was to assess the level of cardiovascular disease (CVD) risk and associated factors among hypertensive patients having follow-up at selected hospitals in Addis Ababa, Ethiopia, in 2022.SettingA hospital-based cross-sectional study was conducted in public and tertiary hospitals in Addis Ababa, Ethiopia, from 15 January 2022 to 30 July 2022.ParticipantsA total of 326 adult hypertensive patients who visited the chronic diseases clinic for follow-up were included in the study.Primary and secondary outcome measuresA high predicted 10-year CVD risk level was assessed using an interviewer-administered questionnaire and physical measurement (primary data) and reviews of medical data records (secondary data) by using a non-laboratory WHO risk prediction chart. Logistic regression with an adjusted OR (AOR) using a 95% CI was calculated for independent variables associated with 10-year CVD risk.ResultsThe prevalence of a high predicted 10-year CVD risk level was 28.2% (95% CI 10.34% to 33.2%) among the study participants. A higher CVD risk level was found to be associated with age (AOR 4.2 for age 64–74, 95% CI 1.67 to 10.66), being male (AOR 2.1, 95% CI 1.18, 3.67), unemployment (AOR 3.2, 95% CI 1.06 to 6.25) and stage 2 systolic blood pressure (AOR 11.32; 95% CI 3.43 to 37.46).ConclusionThe study showed that the respondent’s age, gender, occupation and high systolic blood pressure were determinant factors for CVD risks. Therefore, routine screening for the presence of CVD risk factors and assessment of CVD risk are recommended for hypertensive patients for CVD risk reduction.
Navigating role conflict: one professional’s journey as a new clinician leader
Authors: Wiedman Christopher 
Published: June 2023

Transitioning from full-time clinical work to a leadership position can be a difficult transition for healthcare professionals. Competing demands, new responsibilities and changes in how one measures success in this new role often leave new clinician-leaders feeling lost, stymied or ineffectual.Role conflict is one phenomenon which can impact a healthcare professional’s transition into leadership. Role conflict occurs when the clinician turned leader experiences a sense of dissonance between a highly valued identity as a clinician and a developing identity as a new leader.This article shares my personal experience as a new clinician leader in the field of physical therapy. I offer reflections on the impact of professional role identity conflict during my transition into leadership, and how this role identity conflict led to early leadership failures, but also how addressing role conflict contributed to leadership success later on.More importantly, this article offers advice to the new clinician leader for navigating role identity conflict during a clinical to leadership transition. This advice is based on my personal experience in physical therapy and on the growing body of evidence on this phenomenon in all healthcare professions.
Quantitative Analysis of Postural Balance in Faller and Nonfaller Patients with Parkinson’s Disease
Authors: Kwon Do Young , Kwon Yuri , Choi Ji-An , Ko Junghyuk , Kim Ji-Won 
Published: June 2023

Background. Postural instability has been identified as a fall risk factor with a significant impact on the quality of life of patients with Parkinson’s disease (PD). The aim of this study was to compare the center of pressure (COP) between faller and nonfaller patients with PD during static standing. Methods. Thirty-two faller patients and 32 nonfaller patients with PD participated in this study. All patients performed the static balance test on a force plate. COP data were recorded during quiet standing. Mean distance, sway area, mean velocity, mean frequency, and peak power were derived from the COP data. Statistical analysis was performed using independent t-tests to compare faller and nonfaller patients. Results. Fallers presented a greater average distance, wider sway area, faster average speed, and greater peak power than nonfallers (

p

< 0.05). In contrast, no significant group differences were observed in peak frequency and mean frequency (

p

> 0.05). Conclusions. Although falls occur during dynamic activities, our study demonstrated that even a safe and simple static postural balance test could significantly differentiate between faller and nonfaller patients. Thus, these results suggest that quantitatively assessed static postural sway variables would be useful for distinguishing prospective fallers among PD patients.
A Phase Ib, Open-label Study Evaluating the Safety and Efficacy of Ipatasertib plus Rucaparib in Patients with Metastatic Castration-resistant Prostate Cancer
Authors: Pook David , Geynisman Daniel M. , Carles Joan , de Braud Filippo , Joshua Anthony M. , Pérez-Gracia José Luis , Llácer Pérez Casilda , Shin Sang Joon , Fang Bruno , Barve Minal , Maruzzo Marco , Bracarda Sergio , Kim Miso , Kerloeguen Yannick , Gallo Jorge Daniel , Maund Sophia L. , Harris Adam , Huang Kuan-Chieh , Poon Victor , Sutaria Dhruvitkumar S. , Gurney Howard 
Published: June 2023

Abstract

Purpose:
To report the safety and efficacy of ipatasertib (AKT inhibitor) combined with rucaparib (PARP inhibitor) in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with second-generation androgen receptor inhibitors.

Patients and Methods:
In this two-part phase Ib trial (NCT03840200), patients with advanced prostate, breast, or ovarian cancer received ipatasertib (300 or 400 mg daily) plus rucaparib (400 or 600 mg twice daily) to assess safety and identify a recommended phase II dose (RP2D). A part 1 dose-escalation phase was followed by a part 2 dose-expansion phase in which only patients with mCRPC received the RP2D. The primary efficacy endpoint was prostate-specific antigen (PSA) response (≥50% reduction) in patients with mCRPC. Patients were not selected on the basis of tumor mutational status.

Results:
Fifty-one patients were enrolled (part 1 = 21; part 2 = 30). Ipatasertib 400 mg daily plus rucaparib 400 mg twice daily was the selected RP2D, received by 37 patients with mCRPC. Grade 3/4 adverse events occurred in 46% (17/37) of patients, with one grade 4 adverse event (anemia, deemed related to rucaparib) and no deaths. Adverse events leading to treatment modification occurred in 70% (26/37). The PSA response rate was 26% (9/35), and the objective response rate per Response Criteria in Solid Tumors (RECIST) 1.1 was 10% (2/21). Median radiographic progression-free survival per Prostate Cancer Working Group 3 criteria was 5.8 months [95% confidence interval (CI), 4.0–8.1], and median overall survival was 13.3 months (95% CI, 10.9–not evaluable).

Conclusions:
Ipatasertib plus rucaparib was manageable with dose modification but did not demonstrate synergistic or additive antitumor activity in previously treated patients with mCRPC.
Machine Learning for Prediction of Adverse Cardiovascular Events in Adults With Repaired Tetralogy of Fallot Using Clinical and Cardiovascular Magnetic Resonance Imaging Variables
Authors: Ishikita Ayako , McIntosh Chris , Hanneman Kate , Lee Myunghyun M. , Liang Tiffany , Karur Gauri R. , Roche S. Lucy , Hickey Edward , Geva Tal , Barron David J. , Wald Rachel M. 
Published: June 2023

Background:
Existing models for prediction of major adverse cardiovascular events (MACE) after repair of tetralogy of Fallot have been limited by modest predictive capacity and limited applicability to routine clinical practice. We hypothesized that an artificial intelligence model using an array of parameters would enhance 5-year MACE prediction in adults with repaired tetralogy of Fallot.

Methods:
A machine learning algorithm was applied to 2 nonoverlapping, institutional databases of adults with repaired tetralogy of Fallot: (1) for model development, a prospectively constructed clinical and cardiovascular magnetic resonance registry; (2) for model validation, a retrospective database comprised of variables extracted from the electronic health record. The MACE composite outcome included mortality, resuscitated sudden death, sustained ventricular tachycardia and heart failure. Analysis was restricted to individuals with MACE or followed ≥5 years. A random forest model was trained using machine learning (n=57 variables). Repeated random sub-sampling validation was sequentially applied to the development dataset followed by application to the validation dataset.

Results:

We identified 804 individuals (n=312 for development and n=492 for validation). Model prediction (area under the curve [95% CI]) for MACE in the validation dataset was strong (0.82 [0.74–0.89]) with superior performance to a conventional Cox multivariable model (0.63 [0.51–0.75];
P
=0.003). Model performance did not change significantly with input restricted to the 10 strongest features (decreasing order of strength: right ventricular end-systolic volume indexed, right ventricular ejection fraction, age at cardiovascular magnetic resonance imaging, age at repair, absolute ventilatory anaerobic threshold, right ventricular end-diastolic volume indexed, ventilatory anaerobic threshold % predicted, peak aerobic capacity, left ventricular ejection fraction, and pulmonary regurgitation fraction; 0.81 [0.72–0.89];
P
=0.232). Removing exercise parameters resulted in inferior model performance (0.75 [0.65–0.84];
P
=0.002).

Conclusions:
In this single-center study, a machine learning-based prediction model comprised of readily available clinical and cardiovascular magnetic resonance imaging variables performed well in an independent validation cohort. Further study will determine the value of this model for risk stratification in adults with repared tetralogy of Fallot.
Preserving Trust: Strength of Contracts and Abuses of the Spanish Inquisition
Authors: Rosolino Riccardo 
Published: June 2023

Abstract
The impacts of the Spanish Inquisition in Sicily were manifold, affecting politics, business, and society. Those closely associated with the Inquisition could exercise the privilegium fori by having legal issues settled in the tribunal’s court by inquisitorial judges. Waiving this privilege could guarantee to other parties to a contract that their agreement could not be overruled by the tribunal. Waiving the right to the privilegium fori was institutionalized as such a guarantee to individuals contracting business in a society disciplined by different types of justice based on multiple legal systems.
Genomic landscape of TP53-mutated myeloid malignancies
Authors: Abel Haley J. , Oetjen Karolyn A. , Miller Christopher A. , Ramakrishnan Sai M. , Day Ryan B. , Helton Nichole M. , Fronick Catrina C. , Fulton Robert S. , Heath Sharon E. , Tarnawsky Stefan P. , Nonavinkere Srivatsan Sridhar , Duncavage Eric J. , Schroeder Molly C. , Payton Jacqueline E. , Spencer David H. , Walter Matthew J. , Westervelt Peter , DiPersio John F. , Ley Timothy J. , Link Daniel C. 
Published: June 2023

Abstract
TP53-mutated myeloid malignancies are associated with complex cytogenetics and extensive structural variants, which complicates detailed genomic analysis by conventional clinical techniques. We performed whole-genome sequencing (WGS) of 42 acute myeloid leukemia (AML)/myelodysplastic syndromes (MDS) cases with paired normal tissue to better characterize the genomic landscape of TP53-mutated AML/MDS. WGS accurately determines TP53 allele status, a key prognostic factor, resulting in the reclassification of 12% of cases from monoallelic to multihit. Although aneuploidy and chromothripsis are shared with most TP53-mutated cancers, the specific chromosome abnormalities are distinct to each cancer type, suggesting a dependence on the tissue of origin. ETV6 expression is reduced in nearly all cases of TP53-mutated AML/MDS, either through gene deletion or presumed epigenetic silencing. Within the AML cohort, mutations of NF1 are highly enriched, with deletions of 1 copy of NF1 present in 45% of cases and biallelic mutations in 17%. Telomere content is increased in TP53-mutated AMLs compared with other AML subtypes, and abnormal telomeric sequences were detected in the interstitial regions of chromosomes. These data highlight the unique features of TP53-mutated myeloid malignancies, including the high frequency of chromothripsis and structural variation, the frequent involvement of unique genes (including NF1 and ETV6) as cooperating events, and evidence for altered telomere maintenance.
Assessing competence needs for doctors in the emergency department duty rosters: an observational study
Authors: Kolnes Johannes , Hodneland Erlend , Lange Audun , Heggestad Torhild 
Published: June 2023

Abstract
Background
The purpose of our investigation is to analyze if emergency epidemiology is randomly variable or predictable. If emergency admissions show a predictable pattern, we can use it for multiple planning purposes, especially defining competence needs for duty roster personnel.

Method
An observational study of consecutive emergency admissions at Haukeland University Hospital in Bergen over six years. We extracted the discharge diagnoses from our electronic patient record and sorted the patients by diagnoses and frequency. Data were loaded into a Jupyter notebook and presented in form of frequency diagrams.
The study population, 213,801 patients, comprises all emergency admissions in need of secondary emergency care from the relevant specialities in the catchment area of our hospital in the western health region of Norway. Patients in need of tertiary care from the whole region are also included.

Results
Our analysis shows an annually reproducible distribution pattern regarding type and number of patients. The pattern adhere to an exponential curve that is stable from year to year. An exponential distribution pattern also applies when we sort patients according to the capital letters groups in the ICD 10 system. The same applies if patients are sorted adhering to primarily surgical or medical diagnoses.

Conclusion
Analysis of the emergency epidemiology of all admitted emergency patients in a defined geographical area gives a solid basis for defining competence needs for duty roster work.