bluuebunny/crossref_metadata_2025_split huggingface dataset:
Marketing claims on the websites of leading e-cigarette brands in England
Authors: Nottage Matilda Kim , Taylor Eve Violet , Kim Yebin , Soh Nicole , Hammond David , Simonavicius Erikas , McNeill Ann , Arnott Deborah , East Katherine 
Published: July 2023

Introduction
Exposure to electronic cigarette (EC) marketing is associated with EC use, particularly among youth. In England, the Tobacco and Related Products Regulations and Committee of Advertising Practice (CAP) regulate EC marketing to reduce appeal to youth; however, there are little published data on EC marketing claims used online. This study therefore provides an overview of marketing claims present on the websites of EC brands popular in England.

Methods
From January to February 2022, a content analysis of 10 of England’s most popular EC brand websites was conducted, including violation of CAP codes.

Results
Of the 10 websites, all presented ECs as an alternative to smoking, 8 as a smoking cessation aid and 6 as less harmful than smoking. Four websites presented ECs as risk-free. All mentioned product quality, modernity, convenience, sensory experiences and vendor promotions. Nine featured claims about flavours, colours, customisability and nicotine salts. Seven featured claims concerning social benefits, personal identity, sustainability, secondhand smoke and nicotine strength. Six featured claims about fire safety. Some claimed ECs are cheaper than tobacco (n=5), cited health professionals (n=4) or featured collaborations with brands/icons (n=4). All were assessed by the research team to violate one or more CAP code(s) by featuring medicinal claims (n=8), contents which may appeal to non-smokers (n=7), associations with youth culture (n=6), depictions of youth using ECs (n=6) or media targeting youth (n=5).

Conclusion
Among 10 top EC brand websites in England, marketing elements that might appeal to youth were commonly identified and CAP code compliance was low.
Doctors Versus YOLO: Comparison Between YOLO Algorithm, Orthopedic and Traumatology Resident Doctors and General Practitioners on Detection of Proximal Femoral Fractures on X-ray Images with Multi Methods
Authors: Zeren Muhammed Taha , Arslankaya Seher , Altuntaş Yusuf , Cam Necmi , Kırelli Yasin , Özdemir Mustafa Hacı 
Published: July 2023

In the 1950s, the concept of artificial intelligence emerged, suggesting that machines could possess the ability to think and learn. In the 21st century, with advancements in GPUs and CPUs, deep learning has become an integral part of human life. Proximal femoral fractures are known to be one of the leading causes of mortality and injuries among the elderly population. This study aims to detect proximal femoral fractures in X-ray images and compare the success of using the YOLOv4 algorithm and provide decision support system within the diagnosis. To retrain the algorithm, more than 500 patients’ X-ray images were examined. Through data augmentation techniques, the initial set of 410 patients’ femur proximal fracture X-ray images was expanded to 820 images. After retraining the YOLO algorithm, two different groups were included for comparing the algorithm’s performance: orthopedic specialists and general practitioners. The results from these three groups were evaluated using specific criteria. The YOLOv4 model demonstrated an accuracy of 90.33%. In comparison, orthopedic and traumatology resident doctors achieved an accuracy of 91.42%, while the general practitioner group achieved an accuracy of 81.30%.
MICRO-GROOVING OF ALUMINUM-BASED COMPOSITES USING Nd:YAG LASER MACHINING
Authors: KUMARAN S. THIRUMALAI , UTHAYAKUMAR M. , WYSZYŃSKI DOMINIK , MAJID M. S. ABDUL 
Published: July 2023

This paper describes the pulsed Nd:YAG laser machining characteristics on 6351 aluminum reinforced with silicon carbide (SiC) and boron carbide (B4C) particles. The composites are prepared using stir casting route by varying the weight percentage of B4C (0, 5, and 10 wt.%). During experimentation, the traverse speed (5, 15, and 30 mm/s) and the laser pulse frequency (5, 9, and 15 kHz) are considered to evaluate the groove width. The results reveal that the lower pulse frequency produced poor groove surface quality. Higher thermal energy dissipation at lower traverse speed may also result in the formation of recast layer and heat-affected zone. This is evident from the microscopic image and the EDS analysis. Thus, the optimum condition (composite with 10 wt.% B4C machined at 30 mm/s and 15 kHz) to achieve minimum grove width with improved surface morphology is identified by desirability analysis. Additionally, the regression model is developed to predict future values ([Formula: see text]2 at 91.86% and [Formula: see text]2 (adj) at 87.55%). Finally, the probability plot confirms the effectiveness of the proposed model at 95% confidence level.
What Floodplain Managers Want: Using Weather and Climate Information for Decision-Making
Authors: VanBuskirk Olivia G. , McPherson Renee A. , Mullenbach Lauren E. 
Published: July 2023

Abstract
As a result of climate change, extreme precipitation events are likely to become more common in Oklahoma, requiring cities and municipalities to plan for managing this extra water. There are multiple types of practitioners within communities who are responsible for overseeing planning for the future, including stormwater and floodplain management. These practitioners may be able to integrate weather and climate information into their decision-making to help them prepare for heavy precipitation events and their impacts. Floodplain managers from central and eastern Oklahoma were interviewed to learn what information they currently use and how it informs their decision-making. When making decisions in the short term, floodplain managers relied on weather forecasts; for long-term decisions, other factors, such as constrained budgets or the power of county officials, had more influence than specific climate predictions or projections. On all time scales, social networks and prior experience with flooding informed floodplain managers’ decisions and planning. Overall, information about weather and climate is just one component of floodplain managers’ decision-making processes. The atmospheric science community could work more collaboratively with practitioners so that information about weather and climate is more useful and, therefore, more relevant to the types of decisions that floodplain managers make.
Utilities Estimated from PROMIS Scales for Cost-Effectiveness Analyses in Stroke
Authors: Thompson Nicolas R. , Lapin Brittany R. , Katzan Irene L. 
Published: July 2023

Background The EQ-5D and Health Utilities Index Mark 3 (HUI-3) are preference-based measures used in cost-effectiveness studies. The Patient Reported Outcomes Measurement Information System (PROMIS) Preference scoring system (PROPr) is a new preference-based measure. In addition, algorithms were previously developed to map PROMIS Global Health (PROMIS-GH) items to HUI-3 using linear equating (HUILE) and 3-level EQ-5D using linear (EQ5DLE). We sought to evaluate and compare estimated utilities based on PROPr and PROMIS-GH in adult stroke survivors. Methods We performed a retrospective cohort study of adults diagnosed with 1 of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage seen in an outpatient clinic between 2015 and 2019. Patients completed PROMIS scales and other measures. We computed a modified version of PROPr (mPROPr) and compared the distributional characteristics and correlations with stroke outcomes for mPROPr, HUILE, and EQ5DLE. Results T toal of 4,159 stroke survivors (average age 62.7 ± 14.7 y, 48.4% female, 77.6% ischemic stroke) were included. Mean utility estimates for mPROPr, EQ5DLE, and HUILE were 0.333 ± 0.244, 0.739 ± 0.201, and 0.544 ± 0.301, respectively. Correlations between the modified Rankin Scale and each of mPROPr and HUILE were both −0.48 and −0.43 for EQ5DLE. Regression analyses indicated that mPROPr scores may be too low for stroke patients in good health and that EQ5DLE scores may be too high for stroke patients in poor health. Conclusions All 3 PROMIS-based utilities were associated with measures of stroke disability and severity, but the distributions of utilities were very different. Our study highlights the problem cost-effectiveness researchers face of valuing health states with certainty. For researchers using utilities estimated from PROMIS scales, our study indicates that mapping PROMIS-GH item scores to HUI-3 via linear equating may be most appropriate in stroke patients. Highlights A new preference-based measure has been developed from the Patient Reported Outcomes Measurement Information System (PROMIS), known as the PROMIS-Preference (PROPr) scoring system, and published equations mapping PROMIS Global Health (PROMIS-GH) items to the Health Utilities Index Mark 3 (HUI-3) and EQ-5D-3L are available for use in cost-effectiveness studies. Our study provides distributional characteristics and comparisons of utilities estimated using a modified version of PROPr and equations mapping PROMIS-GH items to EQ-5D-3L and HUI-3 in a sample of stroke survivors. The results of our study show large differences in the distributions of utilities estimated using the different health state measures, and these differences highlight the ongoing difficulty researchers face in valuing health states with certainty.
Silencing of long noncoding RNA X-inactive specific transcript alleviates Aβ1-42-induced microglia-mediated neurotoxicity by shifting microglial M1/M2 polarization
Authors: Zhao Kun-Peng , Wang Xin-Yu , Shao Mei-Qi , He Chen-Yang , Yuan Fu-Qiang 
Published: July 2023

Objectives This experimental study aims to investigate the role of long noncoding RNA X-inactive specific transcript (lncRNA XIST) in the microglial polarization and microglia-mediated neurotoxicity in Alzheimer’s disease (AD). Methods The levels of XIST and microRNA-107 (miR-107) were detected by quantitative real-time polymerase chain reaction. The spatial learning and memory capability of APPswe/PS1dE9 (APP/PS1) mice were evaluated by the Morris water maze test. The morphology of mouse hippocampus cells was evaluated by hematoxylin and eosin staining. The Iba1-positive microglia were labeled by immunohistochemistry staining. The protein levels were determined by western blot and enzyme-linked immunosorbent assay. Neurotoxicity was evaluated by the terminal deoxynucleotidyl transferase–mediated dUTP nick end labeling, caspase-3 activity, and Cell Counting Kit-8 assay. The XIST, miR-107, and AD targets were predicted by bioinformatics analysis. Results The level of XIST was increased in APP/PS1 mice, and XIST silencing ameliorated AD progression. XIST silencing suppressed microglia activation, microglial M1 polarization, and proinflammatory factor levels, but promoted microglial M2 polarization in APP/PS1 mice and Aβ1-42-treated BV-2 cells. XIST knockdown reduced Aβ1-42-induced microglia-mediated apoptosis and enhanced cell viability in HT22 cells. XIST silencing down-regulated miR-107 level and attenuated Aβ1-42-caused suppression of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling. Those effects of XIST silencing were attenuated by miR-107 inhibitor or LY294002. Conclusion Downregulation of XIST lessened Aβ1-42-induced microglia-mediated neurotoxicity by modulating microglial M1/M2 polarization, which may be mediated by the miR-107/PI3K/Akt pathway.
Serious Psychological Distress, Substance Use Disorders, and Social Issues Among Men and Women in the United States During the COVID-19 Pandemic
Authors: Gray Joy , Santos-Lozada Alexis R. , Hard Greg , Apsley Hannah , O’Sullivan Deirdre , Jones Abenaa A. 
Published: July 2023

Purpose This study assesses the association between SUD, economic hardship, gender, and related risk and protective factors on serious psychological distress (SPD) during the COVID-19 pandemic. Design Quantitative cross-sectional design. Setting National Survey on Drug Use and Health (NSDUH). Sample Data were from the NSDUH (2020) N = 25,746, representing 238,677,123 US adults, who identified as 18 or older and either male or female. Measures SPD measured as scoring a 13 or more on the Kessler (K6) distress scale. SUDs were determined using DSM5 criteria. Sociodemographic and socioeconomic variables included in analyses. Analysis Logistic regressions evaluated the association between gender, protective, and risk factors on SPD. Results After controlling for sociodemographic and related factors of SPD, having a SUD was the strongest correlate of SPD. Other significant correlates of SPD included female gender and an income level at or below the federal poverty threshold. Gender stratified regressions illustrated that religiosity, self-identifying as Black, and high levels of education were protective against SPD for women but not men. Poverty level was more associated with SPD for women than men. Conclusion In the United States, individuals with SUDs were nearly four times more likely to report SPD than those without SUDs, controlling for economic hardship and markers of social support during 2020. Effective social interventions to reduce SPD among individuals with SUDs are needed.
Tailoring mechanical and electrical properties of polydimethylsiloxane nanocomposites With graphene and carbon nanotubes for wearable electronics
Authors: Huang Sheng-Yang , Wu Tair-I , Chou Chia-Man , Hsiao Vincent K.S. 
Published: July 2023

We explored the use of soft and flexible graphene (Gr)-reinforced polydimethylsiloxane (PDMS; Gr-PDMS) and Gr-carbon nanotube (CNT)-reinforced PDMS (Gr-CNT-PDMS) as nanocomposites (NCPs) in wearable electronic applications and investigated their mechanical and electrical properties. Specifically, we evaluated the mechanical reinforcement of the NCPs by performing Shore scleroscope hardness and machine-washing tests and evaluated their electrical properties by using a four-point probe. The results revealed that as the Gr or CNT concentrations increased, the NCPs’ hardness and surface resistance increased and decreased, respectively. Scanning electron microscopy revealed the formation of layered polymeric structures in the Gr-PDMS NCPs, contributing to the increase in hardness and decrease in surface resistance. Furthermore, bending tests revealed that changes in resistance were positively correlated with the Gr concentration. PDMS with low Gr concentrations exhibited no substantial changes in surface resistance after bending tests. However, for PDMS, as the Gr concentration increased (>5 wt.%), the cross-sectional morphology observed after 500 bending cycles differed substantially from that before observed bending tests. Additionally, the influence of one-dimensional (CNT) and two-dimensional (Gr) nanomaterials on the mechanical and electrical properties of the flexible PDMS samples was investigated. The aim of this study is to highlight the importance of considering the properties of different nanomaterials in developing high-performance NCPs for wearable electronics.
Acute auto-aggression syndrome following autologous hematopoietic stem cell transplant and lenalidomide for multiple myeloma
Authors: Struble Emily , Ginn Meredith , Strouse Christopher 
Published: July 2023

Introduction Autologous hematopoietic stem cell transplant is an important treatment modality used to achieve long-term remission in people with multiple myeloma. Complications include chemotherapy-related toxicity or infection. Rarely, clinical features consistent with autologous graft-versus-host disease, otherwise known as auto-aggression syndrome, is possible. Auto-aggression syndrome appears more commonly in patients with multiple myeloma, hypothesized to be a result of underlying immune dysregulation, conditioning chemotherapy, or treatment with immunomodulating agents. Case report A 66-year-old female with multiple myeloma underwent an autologous stem cell transplant with melphalan conditioning chemotherapy followed by maintenance therapy with lenalidomide. Transplant was complicated by engraftment syndrome versus auto-aggression syndrome. After lenalidomide maintenance therapy initiation, she required hospitalization for auto-aggression syndrome. Management and outcome Auto-aggression syndrome with gastrointestinal, hepatic, and dermatologic involvement as demonstrated by skin punch biopsy, elevated reg3α, ST2, elafin, eosinophilia, transaminitis, and persistent diarrhea beyond the engraftment period were noted. Topical and systemic steroids with a prolonged taper resulted in symptom resolution. Discussion Acute graft-versus-host disease is a complication once considered unique to allogeneic stem cell transplant recipients, but a similar syndrome termed “auto-aggression syndrome” may be seen following autologous transplant. Auto-aggression syndrome should be suspected when complications extend beyond the normal engraftment syndrome period following autologous transplant, particularly in people with multiple myeloma, and/or those who have received prior immunomodulating therapy. There should be a low threshold for obtaining biopsies in the setting of suspected auto-aggression syndrome. Early recognition and prompt initiation of corticosteroids with prolonged tapers may prevent auto-aggression syndrome relapse and readmissions.
Fucosyltransferase 5 Promotes the Proliferative and Migratory Properties of Intrahepatic Cholangiocarcinoma Cells via Regulating Protein Glycosylation Profiles
Authors: Guo Jingheng , Cheng Qian , Li Yongjian , Tian Lingyu , Ma Delin , Li Zhao , Gao Jie , Zhu Jiye 
Published: July 2023

Background: The incidence of intrahepatic cholangiocarcinoma (ICC) is increasing globally, and its prognosis has not improved substantially in recent years. Understanding the pathogenesis of ICC may provide a theoretical basis for its treatment. In this study, we investigated the effects and underlying mechanisms of fucosyltransferase 5 (FUT5) on the malignant progression of ICC. Methods: FUT5 expression in ICC samples and adjacent nontumor tissues was compared using quantitative real-time polymerase chain reaction and immunohistochemical assays. We performed cell counting kit-8, colony formation, and migration assays to determine whether FUT5 influenced the proliferation and mobility of ICC cells. Finally, mass spectrometry was performed to identify the glycoproteins regulated by FUT5. Results: FUT5 mRNA was significantly upregulated in most ICC samples compared with corresponding adjacent nontumor tissues. The ectopic expression of FUT5 promoted the proliferation and migration of ICC cells, whereas FUT5 knockdown significantly suppressed these cellular properties. Mechanistically, we demonstrated that FUT5 is essential for the synthesis and glycosylation of several proteins, including versican, β3 integrin, and cystatin 7, which may serve key roles in the precancer effects of FUT5. Conclusions: FUT5 is upregulated in ICC and promotes ICC development by promoting glycosylation of several proteins. Therefore, FUT5 may serve as a therapeutic target for the treatment of ICC.
ABS-SMART (Aortic Balloon Supporting for Superior Mesenteric Artery Recanalization Technique): A New Technical Option for Recanalization of Complete Superior Mesenteric Artery Occlusion in Chronic Mesenteric Ischemia
Authors: Guerra Requena M. , Badell Fabelo M. , Blanco Cañibano E. , Franch Oviedo F. , Recover Palenzona A. , Baturone Blanco A. 
Published: July 2023

Objective: To report our experience with a new technique for recanalization of the superior mesenteric artery (SMA)/celiac trunk (CT) with complete occlusion at the origin. Technique: We describe our ABS-SMART (Aortic Balloon Supporting for Superior Mesenteric Artery Recanalization Technique) for recanalization of the CT and SMA in cases of complete occlusion of these arteries with a short or inexistent stump, which usually corresponds to chronic lesions with important calcification of the ostium. Conclusion: The ABS-SMART is an alternative for the recanalization of visceral arteries in cases where other conventional techniques have failed. It is particularly useful in scenarios characterized by a short occlusion at the origin of the target vessel, with no entry stump or severe calcification at the origin. Clinical Impact Catheterization and recanalization of visceral stenoses may pose a challenge in some cases, as for example in the presence of a very narrow angle between the root or origin of the vessel and the aorta, as well as in the case of long and calcified stenoses, or when arteriography is unable to visualize the origin of the vessel. The present study describes our experience with the endovascular revascularization of visceral vessels using an aortic balloon-supported recanalization technique not previously described in the literature, that may be an effective alternative for the treatment of lesions of difficult access, such as total occlusion at the origin of the target vessel, with no entry stump or severe calcification at the origin of the SMA and CT, by improving the chances for technical success.
Outcomes of 218 primary single-finger flexor tendon repairs up to 1 year after surgery: a multicentre cohort study
Authors: Tobler-Ammann Bernadette , Beckmann-Fries Vera , Calcagni Maurizio , Kämpfen Alexandre , Schrepfer Lorena , Vögelin Esther 
Published: July 2023

In this retrospective multicentre cohort study, we present the results of primary single-finger flexor tendon repairs in zones 1 to 3 between 2014 and 2021. Data from 218 patients were retrieved with their demographics, injury and surgery characteristics and therapy outcomes. The data were systematically collected and analysed at predefined time points up to 1 year after surgery. A good to excellent return of motion was achieved by 77% (Tang classification) and 92% (American Association for Surgery of the Hand classification) of patients at 1 year. The tendon rupture rate was 8.7%. Time had a significant impact on the recovery of finger motion and grip strength of up to 1 year, of patient satisfaction and upper extremity function up to 26 weeks, and of pain up to 13 weeks after surgery. Our results demonstrate that it is worthwhile to assess therapy outcomes over various measurement periods, as some outcomes may continue to improve up to 1 year after flexor tendon repair surgery. Level of evidence: III
Trends in maternal ICU admissions at a quaternary centre in Montreal, Canada, and impact of maternal age on critical care outcomes
Authors: Lopez Laporte Maria Agustina , Shahin Jason , Blotsky Andrea , Malhamé Isabelle , Dayan Natalie 
Published: July 2023

Background Advancing maternal age is increasingly prevalent and is associated with severe maternal morbidity often requiring intensive care unit (ICU) admission. Objectives To describe maternal ICU admissions at a quaternary care hospital in Montreal, Canada, and evaluate the association between maternal age and composite of: need for invasive interventions, ICU stay > 48 h, or maternal death. Methods Chart review of ICU admissions during pregnancy/postpartum (2006–2016); logistic regressions to evaluate the impact of age on outcomes. Results With 5.1 ICU admissions per 1000 deliveries, we included 187 women (mean age 32 ± 6.3 years; 20 (10.7%) ≥ 40 years). The composite outcome occurred in 105 (56.2%) patients; there were two maternal deaths. Age ≥ 40 years increased the odds of invasive interventions (OR 4.03; 95% confidence interval [CI] 1.15–14.1) but not of the composite outcome (OR 2.30; 95% CI 0.66–8.02). Conclusion Peripartum women aged ≥ 40 years had worse outcomes in ICU, with an increased need for invasive interventions.