bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the Efficacy and Safety of Nebulized Gentamicin Plus Amikacin
versus Tobramycin in Patients with Cystic Fibrosis
Authors: Kouhestani Fatemeh , Hassanzad Maryam , Baniasadi Shadi 
Published: February 2023

Background:
Cystic fibrosis is an autosomal recessive disease that causes respiratory
tract infection. These patients use nebulized antibiotics such as tobramycin and gentamicin plus
amikacin. Due to the high price of tobramycin and the inaccessibility of this drug in Iran at different
periods, we aimed to compare the efficacy and safety of nebulized plus amikacin and tobramycin
in patients with cystic fibrosis.

Methods:
In this analytic cross-sectional study, data were collected from the records of all patients with
cystic fibrosis. They were divided into two groups by their type of nebulized antibiotic. Group 1 included
41 patients who received 80 mg gentamicin and 500 mg amikacin as a nebulized antibiotic every other
month, whereas, group 2 consisted of 9 patients who received 300 mg nebulized tobramycin. Collected
data were pulmonary function parameters, body mass index, the frequency of hospitalization, infection
progress, Shwachman-Kulczycki score, and renal complications. The data were compared in terms of
efficacy and renal adverse effects by independent t-test and repeated measure ANOVA.

Results:
A total of 50 cystic fibrosis patients were evaluated and there was no significant difference
between group 1 and group 2 in terms of pulmonary function, frequency of hospitalizations,
body mass index, Shwachman-Kulczycki score, infection progress, and renal complications. Notably,
pulmonary function factors were reduced in both groups over time during their treatment.

Conclusion:
Nebulized tobramycin and gentamicin plus amikacin had similar efficacy against
Pseudomonas aeruginosa in cystic fibrosis and had no serious renal complications.
New 1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-2-phenylisoquinoline-1(2H)-ones
as Phosphoinositide 3-kinase Inhibitors for Treating Cancer and Other Diseases
Authors: De Surya K. 
Published: February 2023

Abstract:
The patent describes novel useful compounds, such as PI3K protein kinase inhibitors, in
particular as PI3K delta (δ) and/or gamma (γ) protein kinase modulators. The present disclosure
also provides methods for preparing PI3K protein kinase inhibitors, pharmaceutical compositions
containing them, and methods of treatment, prevention, and amelioration of PI3K kinase-mediated
diseases, and disorders.
Marburg Virus- A Threat During SARS-CoV-2 Era: A Review
Authors: Ashique Sumel , Chaudhary Vatan , Pal Soumen , Panwar Jonee , Kumar Mukesh , Pramanik Soumi , Sinha Abhipsa , Mukherjee Anagh 
Published: February 2023

Abstract:
In the German towns of Marburg, Frankfurt, and Belgrade in 1967, this single negativestranded
RNA virus was initially discovered. The importation of infected grivet monkeys from Uganda
is what caused this virus-related sickness. As a result of the early link between viruses and non-human
primates, this virus is frequently referred to as vervet monkey sickness. This virus causes Marburg
hemorrhagic fever in humans and non-human primates. Human endothelial cells serve as the primary
vehicle for replication. According to a 2009 report, the virus was being stored in Egyptian fruit bats
(Rousettus aegyptiacus). Body fluids, unprotected sex, broken or injured skin, and other bodily fluids
are the main routes of transmission. After the incubation period, symptoms like chills, headaches, myalgia,
and stomach pain start to show up. There is no specific medication for such an infection, only
hydration therapy and adequate oxygenation are followed. The following diagnostic techniques can be
used to confirm the diagnosis: (i) an antibody-capture enzyme linked immunosorbent assay (ELISA);
ii) an antigen capture ELISA test; iii) a serum neutralization test; iv) an RT PCR assay; v) electron
microscopy; or vi) virus isolation by cell culture. Because MARV is a risk group 4 infection, laboratory
staff must take strict precautions (RG-4).
Promising Radiopharmaceutical Tracers for Detection of Cardiotoxicity in
Cardio-oncology
Authors: Shaghaghi Zahra , Jalali Zefrei Fatemeh , Salari Arsalan , Hojjati Seyed Amineh , Fakhr Mousavi Seyed Aboozar , Farzipour Soghra 
Published: February 2023

Abstract:
Cancer treatment has the potential to cause cardiovascular issues and can encourage the
appearance of all aspects of cardiac disease, including coronary heart disease, myocardial disease,
heart failure, structural heart disease, and rhythm problems. Imaging is required for both diagnostic
workup and therapy monitoring for all possible cardiovascular side effects of cancer therapy.
Echocardiography is the cardiac imaging gold standard in cardio-oncology. Despite advancements
in its use, this method is often not sensitive to early-stage or subclinical impairment. The use of
molecular imaging technologies for diagnosing, assessing, and tracking cardiovascular illness as
well as for treating, it is fast growing. Molecular imaging techniques using biologically targeted
markers are gradually replacing the traditional anatomical or physiological approaches. They offer
unique insight into patho-biological processes at the molecular and cellular levels and enable the
evaluation and treatment of cardiovascular disease. This review paper will describe molecularbased
single-photon emission computed tomography (SPECT) and positron emission tomography
(PET) imaging techniques that are now available and in development to assess post-infarction cardiac
remodeling. These methods could be used to evaluate important biological processes such as
inflammation, angiogenesis, and scar formation.
Formulación de una propuesta de Ley para desarrollar la transformación digital del Ecuador.
Authors: Barragán Martínez Xavier 
Published: February 2023

La presente investigación tiene como objetivo el formular una propuesta de ley para la transformación digital del Ecuador; basado en una metodología descriptiva cualitativa, a través de talleres de expertos llevados a cabo por el MINTEL, y un análisis documental bibliográfico de fuentes primarias y fuentes secundarias de organismos internacionales y nacionales, se obtuvieron resultados que muestran la imperante necesidad de adecuar el marco legislativo vigente para obligar a las instituciones públicas a establecer comunicación por medios electrónicos; desarrollar y/o usar plataformas digitales sostenibles y reutilizables para la presentación de documentos de manera ininterrumpida; mantener expedientes electrónicos; cooperar e interoperar en todo procedimiento administrativo con las entidades de la Administración Pública, y garantizar la gobernanza pública conformando un comité estratégico con atribuciones para promover el uso y la apropiación de las TIC; así como asesorar, acompañar, coordinar y dar seguimiento al cumplimiento de las políticas en materia de transformación digital.
¿A qué filosofías ha afectado la Neurociencia?
Authors: Vallverdu Jordi 
Published: February 2023

Parece obvio pensar que los avances neurocientíficos, una revolución de finales del siglo XX, han impactado en la Filosofía Contemporánea. Sin embargo, este no es el caso. Como disciplina compuesta de numerosas áreas, todavía está anclada en modelos antropológicos, culturales, epistemológicos y cognitivos propios de siglos (e incluso milenios) anteriores. Revisaremos cuál ha sido el impacto real de las neurociencias en el pensamiento contemporáneo, desde una perspectiva crítica y orientada no sólo al estudio del ser humano, sino también de la IA.
Run Effects of the Short-Run Stabilization Policies in Ukraine
Authors: Poliakova Yuliia , Sokurenko Solomiya 
Published: February 2023

Based on of the quarterly data for the period of 2002-2021 and with the application of ARDL estimates it has been established that in the case of recession there are short-run expansionary effects of government expenditures and exchange rate appreciation. However, government expenditures become contractionary in the long run, along with monetary policy tightening. Liberalisation of economic environment, as indicated by the Index of Economic Freedom from the Heritage Foundation, is expansionary in the long run. Finally, about 80% of deviation from the long-run relationship is corrected in the short run.
Key words: stabilization policy, fiscal-monetary mix, exchange rate, Ukraine, error-correction model (ARDL)
Cenários prospectivos no brasil para telecom no segmento b2b em 2050
Authors: Correia Leonardo Fernandes Coutinho , Sarfati Gilberto 
Published: February 2023

Objetivo: Apresentar uma abordagem de cenários prospectivos para os próximos 30 anos no segmento B2B para as operadoras de telecomunicações no Brasil.
Método: A pesquisa foi realizada pela abordagem quantitativa semiestruturadas suportadas pelo método Delphi e uso da construção de cenários prospectivos de Schwartz (GBN), sendo realizada com especialistas e gestores do setor segmento de Telecom para B2B.
Originalidade/Relevância: As grandes operadoras de telecom no Brasil, estão atualmente diante de um ambiente de diversas variáveis e complexidades trazidas principalmente por concorrências por novos entrantes de TI, operadoras regionais, novas tecnologias emergentes e o movimento de Transformação Digital. O presente artigo apresentou um exercício viável para apoiar no planejamento estratégico de longo prazo, através de cenários prospectivos, de tal maneira a fornecer subsídios para apoio as decisões de hoje.
Resultados: Através da metodologia de cenários prospectivos se desenvolveu a construção de quatro cenários futuros: 1) Democracia da Info-Inovação, 2) Resistência dos Locais-Especiais, 3) Evolução Big Telco-Tech, 4) Grandes Expansionistas.
Contribuições teóricas/metodológicas: Verificou-se que o uso da metodologia de cenários prospectivos pode ser uma ferramenta para o planejamento estratégico, aplicável diante de condições incertas no horizonte de longo prazo.
Contribuições sociais / para a gestão: A contribuição desse artigo está na entrega de um exercício prático que demostrou como os cenários prospectivos podem ser utilizados como um direcionador para as lideranças das empresas em posições estratégicas e ainda como um guia de ações de longo prazo, para todos os participantes dessa empresa.
Pelatihan konseling sebaya untuk mewujudkan profil pelajar pancasila
Authors: Rahmi Rahmi , Dewi Ratna Sari 
Published: February 2023

Pengabdian kepada masyarakat ini bertujuan untuk memberikan pemahaman dan keterampilan pada siswa dalam melaksanakan konseling sebaya. Sasaran pelatihan ini adalah siswa SMP di kota Prabumulih, yang berjumlah 20 orang. Pelatihan ini dilaksanakan secara hybrid dengan kegiatan : pemaparan materi, diskusi, tanyajawab, simulasi, Reflecting and Sharing Experience, dilakukan dengan menggunakan aplikasi zoom meeting dan pendampingan dengan menggunakan WhatsApp. Untuk mengetahui pemahaman siswa terhadap materi yang telah disajikan oleh tim pengabdian, peserta diberikan tes yang dilakukan melalui aplikasi google form, dan untuk mengetahui keterampilan siswa dalam melaksanakan konseling sebaya, dilakukan melalui simulasi dengan menggunakan aplikasi zoom meeting. Hasil evaluasi menunjukkan sekitar 85,4 terjadi peningkatan rata-rata skor pemahaman peserta mengenai materi konseling sebaya dan terdapat 80% peserta yang berada kategori sangat baik dalam melakukan simulasi konseling sebaya.
Логика закона в сфере охраны здоровья
Authors: Зарубина Анна , Тихомиров Алексей 
Published: February 2023

Логика права и логика закона наиболее ярко демонстрируют единство в модели структуры нормы права. В идеале от регулятивов следует ожидать такого упрощения повседневности для всех и каждого, которого позволяют достигнуть умные алгоритмы как пошаговые инструкции решения задач – решенных, протестированных и проверенных. Применительно к сфере охраны здоровья вопрос правомерности поведения актуален, как нигде: в отношении здоровья свободен только правообладатель – в пределах своего права на здоровье. На данном этапе существует логический разрыв между логикой права, логикой закона и реалиями оказания медицинской помощи. Это влечет ее несоответствие в настоящее время как потребностям пользы для здоровья граждан, так и определенности (и определимости) обусловленной ее недостатками вреда, необходимой, прежде всего, в целях надзора и правосудия.
The logic of law and the logic of law most clearly demonstrate the unity in the model of the structure of the rule of law. Ideally, regulators should be expected to simplify everyday life for everyone, which smart algorithms can achieve as step–by-step instructions for solving problems - solved, tested and verified. In relation to the sphere of healthcare, the question of the legality of behavior is relevant as nowhere else: only the rightholder is free in relation to health – within the limits of his right to health. There is a logical gap between the logic of law, the logic of justice and the realities of medical care. It determines an inconsistency of the latter at the present time both with the needs of the benefits for the health of citizens and the certainty of the harm caused by its shortcomings, which is necessary, first of all, for the purposes of state supervision and court procedure.
Analysis of potential application of microbiological flooding at Filanovsky oilfield
Authors: Samatoeva Daria Sergeevna , Vybornova Tatiana Sergeevna 
Published: February 2023

Oil is the most valuable hydrocarbon resource, but every year the labor intensity and economic expenses for oil production increase. This is related to the fact that most oil fields are classified as hard-to-recover reserves, that is why oil companies turn to studying and implementing the methods increasing oil production. To increase well productivity, there are often used mechanical, chemical, thermal and physical methods, as well as a combination of the above methods. Choosing a method firstly depends on the geological conditions of the deposit and the physicochemical properties of the extracted fluid. But application of the methods of increased oil production does not always lead to
a significant increase of the well flow rate. One of the promising, but insufficiently studied methods of increasing oil production is the microbiological impact on the oil formation. The method is based on the ability of bacteria to destroy the reservoir rock, increase porosity and cavernosity, create more channels and increase the filtration area in productive horizons. There is given analysis of the influence of silicate bacteria on the core from the Filanovsky oilfield. This bacterial strain has been chosen because the field rock is to a great extent composed of silicate and aluminosilicate minerals. A significant factor is that silicate bacteria are aerobian, i. e. they do not need free oxygen to maintain vital activity; as a result, they are rather viable in poor conditions. A flow chart is given and the conditions necessary for the introduction of microbiological flooding technology are indicated. There are presented the results of the experiment on using the method of microbiological flooding at the Filanovsky oilfield, changes in the structure of core particles have been revealed indicating active interaction of bacteria with oil.
MIR-147B regulated proliferation and apoptosis of gastric cancer cells by targeting CPEB2 via the PTEN pathway
Authors: К Tao , Dong J-H. , Wang D. , Li F. , Zhang Z-T. 
Published: February 2023

Abstract
The present study has been performed to illustrate the role and mechanism of microRNA-147b (miR-147b) in the cellular viability and apoptosis of gastric cancer (GC) cells. The GC tissues of 50 patients with complete data and the adjacent tissues were selected from Shanxi Cancer Hospital, and 3 pairs of tissues were randomly selected for microarray detection of high-expressing microRNAs. The expressions of miR-147b were quantified in numerous GC cell lines, i.e., BGC-823, SGC-7901, AGS, MGC-803 and MKN-45, normal tissue cell lines and 50 pairs of gastric cancer tissues. Moreover, two cell lines of miR-147b high-expressing used PCR quantitative analysis were selected for transfection experiments. The differentially expressed miR-147b was screened from 3 pairs of samples by miRNA chip. The expression ofmiR-147b was found highly expressed in gastric cancer tissues of 50 pairs of gastric cancer and adjacent tissues. The miR-147b found in diverse range in each of GC cell line. Therefore, two cell lines, BGC-823 and MGC-803, with relatively high expression levels of miR-147b were selected for further analysis and research. Scratch analysis results showed that compared with miR-147b NC, the miR-147b inhibitor group inhibited GC cell growth and reduced cell migration. The early apoptosis of MGC-803, and BGC-823 cells was enhanced by miR-147b inhibitor. miR-147b inhibitor significantly repressed the proliferation of BGC-823 and MGC-803 cells. Our study showed that the high expression of miR-147b is positively correlated with the occurrence and development of gastric cancer.
Keratitis-ichthyosis-deafness syndrome with heterozygous p.D50N in the GJB2 gene in two Serbian adult patients
Authors: Kalezić T , Vuković I , Stojković M , Stanojlović S , Karanović J , Brajušković G , Savić-Pavićević D 
Published: February 2023

Abstract

Purpose
Keratitis-ichthyosis-deafness (KID) syndrome is a rare congenital ectodermal dysplastic syndrome presenting with keratitis, ichthyosis and sensorineural hearing loss. The most common causes of KID syndrome are heterozygous missense mutations in the GJB2 gene that codes for connexin 26.

Case report
During the ophthalmological examination, two adult females complained of recent worsening of visual acuity in both eyes. Anamnesis revealed that their eyes were red and irritated from early childhood onwards. Both of them had thickening and keratinisation of eyelid margins, lash loss, diffuse opacification of cornea and conjunctiva caused by keratinisation of eye surface, superficial and deep corneal vascularisation and corneal oedema. Partial sensorineural hearing loss and difficulties in speech were also noted along with typical ichthyosiform erythroderma. Genetic testing of the GJB2 gene revealed a heterozygous p.D50N mutation in both patients.
Patients were treated with a combined topical corticosteroid and artificial tears therapy, with steroid therapy being intensified during the last month. The therapy increased the visual acuity by decreasing corneal oedema and by forming a more regular air-tear interface during the six months follow up. Subsequently, the disease progressed despite the continuation of the therapy.

Conclusion
This is the first report of Serbian patients with KID syndrome. Despite the administration of the combined topical corticosteroid and artificial tears therapy the disease is relentlessly progressive and therapeutic success of ophthalmological signs with local therapeutic modalities used so far had been disappointing.
Is the cryptocurrency market efficient? Evidence from an analysis of fundamental factors for Bitcoin and Ethereum
Authors: Łęt Blanka , Sobański Konrad , Świder Wojciech , Włosik Katarzyna 
Published: February 2023

Abstract
This article sheds new light on the informational efficiency of the cryptocurrency market by analyzing investment strategies based on structural factors related to on-chain data. The study aims to verify whether investors in the cryptocurrency market can outperform passive investment strategies by applying active strategies based on selected fundamental factors. The research uses daily data from 2015 to 2022 for the two major cryptocurrencies: Bitcoin (BTC) and Ethereum (ETH). The study applies statistical tests for differences. The findings indicate informational inefficiency of the BTC and ETH markets. They seem consistent over time and are confirmed during the COVID-19 pandemic. The research shows that the net unrealized profit/loss and percent of addresses in profit indicators are useful in designing active investment strategies in the cryptocurrency market. The factor-based strategies perform consistently better in terms of mean/median returns and Sharpe ratio than the passive “buy-and-hold” strategy. Moreover, the rate of success is close to 100%.
WORKSHOP PERANCANGAN MULTIMEDIA PEMBELAJARAN BERBASIS VIDEO BAGI MAHASISWA CALON GURU
Authors: Febrilia Baiq Rika Ayu , Sanapiah Sanapiah , Yuntawati Yuntawati , Masjudin Masjudin , Sabrun Sabrun 
Published: February 2023

Program pengabdian kepada masyarakat ini bertujuan untuk memberikan pengetahuan mengenai perancangan multimedia pembelajaran berbasis video kepada mahasiswa calon guru yang dikemas melalui workshop secara online di masa pandemi Covid 19. Fokus kegiatan workshop adalah pada pembuatan video multimedia pembelajaran menggunakan Microsoft PowerPointmelalui teknik screen recording. Ide ini dilandasi dengan pemikiran bahwa mahasiswa calon guru harus memiliki keterampilan tambahan untuk mendukung perannya sebagai guru nanti. Selain itu, perkembangan pembelajaran saat ini menuntut kreativitas guru tanpa batas dengan memanfaatkan perangkat digital untuk dapat membuat siswa tetap terlibat aktif dalam proses pembelajaran, terlebih di masa pandemi ini. Mitra pengabdian ini adalah Program Studi Pendidikan Matematika Universitas Pendidikan Mandalika dan melibatkan 35 mahasiswa semester 5. Pengabdian kepada masyarakat dilaksanakan menggunakan dua tahapan, yaitu tahapan persiapan dan tahapan pelaksanaan. Tahap persiapan digunakan untuk mempersiapkan alat, bahan, jadwal dan kebutuhan-kebutuhan lainnya untuk menunjang lancarnya program. Tahap pelaksanaan meliputi proses implementasi kegiatan pengabdian yang telah diprogramkan. Hasil dari pengabdian ini menunjukkan bahwa mahasiswa mampu merancang tahapan materi dalam video menggunakan storyboard, menghasilkan video pengenalan multimedia pembelajaran dan mengunggahnya pada laman youtube akun masing-masing.
SOSIALISASI DAN EDUKASI PENDIDIKAN ANTIKORUPSI BAGI AKTIVIS MAHASISWA UNIVERSITAS MUHAMMADIYAH JAKARTA
Authors: Sa'diyah Rika , Shofiyah Siti , Siregar Nurhidayah , Kurniawan Kurniawan , Anam Moh Khoirul 
Published: February 2023

Saat ini praktik korupsi di kalangan mahasiswa sudah mulai mengakar dalam berbagai bidang. Aktivis mahasiswa ini bisa dikatakan sebagai bibit koruptor, bila perilakunya tidak mencerminkan perilaku antikorupsi. Hal ini akan berdampak pada kondisi mental generasi militan di masa depan kelak. Lemahnya pengawasan baik dari orang tua ataupun institusi pendidikan (kampus) menjadi salah satu faktor penyebabnya. Metode pelaksanaan peningkatan pendidikan antikorupsi bertumpu pada prinsip membangun budaya antikorupsi adalah proses kolaboratif sehingga pelaksanaanya harus melibatkan aktivis mahasiswa sebagai agent of change. Tujuan kegiatan edukasi dan sosialisasi ini adalah meningkatkan kesadaran dan tanggungjawab aktivis mahasiswa dalam melaksanakan hak dan kewajibannya sebagai generasi muda yang berperilaku antikorupsi. Melalui kegiatan pengabdian masyarakat yang dilakukan oleh Penyuluh Anti Korupsi KPK dan juga dari KOMPAK-UMJ (Komunitas Mahasiswa Penggiat Anti Korupsi-Universitas Muhammadiyah Jakarta) selaku komunitas yang ada di Kampus UMJ, diharapkan para mahasiswa tidak mau untuk berperilaku koruptif, walaupun ada kesempatan.