bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between maternal depressive symptoms and selective serotonin reuptake inhibitor antidepressant treatment on internalising and anxiety behaviours in children: 12-year longitudinal study
Authors: Hutchison Sarah M. , Brain Ursula , Grunau Ruth E. , Kuzeljevic Boris , Irvine Mike , Mâsse Louise C. , Oberlander Tim F. 
Published: February 2023

Background
Prenatal selective serotonin reuptake inhibitor (SSRI) antidepressant exposure is associated with increased internalising and anxious behaviours in young children; whether this continues into early adolescence is unknown. Also, it is not well established whether it is the in utero exposure to SSRIs or the underlying maternal mood that contributes more to these associations.

Aims
To examine associations between maternal depressive symptoms, prenatal SSRI antidepressant treatment and internalising and anxiety behaviours from childhood into pre-adolescence.

Method
From a prospective longitudinal cohort, measures of maternal depressive symptoms and SSRI use and child outcomes (n = 191 births) were obtained from the second trimester to 12 years. Maternal reports of internalising and anxiety behaviours in children were obtained at 3, 6 and 12 years.

Results
Multilevel mixed-effects models revealed that maternal depressed mood at the third trimester assessment, not prenatal SSRI exposure, was associated with longitudinal patterns of higher levels of internalising and anxiety behaviours across childhood from 3 to 12 years of age. At each age, hierarchical regressions showed that maternal mood at the third trimester, compared with current maternal depression or prenatal SSRI exposure, explained a greater proportion of the variance in internalising and anxiety behaviours.

Conclusions
Even with prenatal SSRI treatment, maternal depressed mood during the third trimester still had an enduring effect as it was associated with increased levels of internalising and anxiety behaviours across childhood and into early adolescence. Importantly, we found no evidence of a ‘main effect’ association between prenatal SSRI exposure and internalising and anxiety behaviours in children.
Circulating Tumor DNA Is Prognostic in Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group
Authors: Abbou Samuel , Klega Kelly , Tsuji Junko , Tanhaemami Mohammad , Hall David , Barkauskas Donald A. , Krailo Mark D. , Cibulskis Carrie , Nag Anwesha , Thorner Aaron R. , Pollock Samuel , Imamovic-Tuco Alma , Shern Jack F. , DuBois Steven G. , Venkatramani Rajkumar , Hawkins Douglas S. , Crompton Brian D. 
Published: February 2023

PURPOSE Novel biomarkers are needed to differentiate outcomes in intermediate-risk rhabdomyosarcoma (IR RMS). We sought to evaluate strategies for identifying circulating tumor DNA (ctDNA) in IR RMS and to determine whether ctDNA detection before therapy is associated with outcome. PATIENTS AND METHODS Pretreatment serum and tumor samples were available from 124 patients with newly diagnosed IR RMS from the Children's Oncology Group biorepository, including 75 patients with fusion-negative rhabdomyosarcoma (FN-RMS) and 49 with fusion-positive rhabdomyosarcoma (FP-RMS) disease. We used ultralow passage whole-genome sequencing to detect copy number alterations and a new custom sequencing assay, Rhabdo-Seq, to detect rearrangements and single-nucleotide variants. RESULTS We found that ultralow passage whole-genome sequencing was a method applicable to ctDNA detection in all patients with FN-RMS and that ctDNA was detectable in 13 of 75 serum samples (17%). However, the use of Rhabdo-Seq in FN-RMS samples also identified single-nucleotide variants, such as MYOD1 L122R, previously associated with prognosis. Identification of pathognomonic translocations between PAX3 or PAX7 and FOXO1 by Rhabdo-Seq was the best method for measuring ctDNA in FP-RMS and detected ctDNA in 27 of 49 cases (55%). Patients with FN-RMS with detectable ctDNA at diagnosis had significantly worse outcomes than patients without detectable ctDNA (event-free survival, 33.3% v 68.9%; P = .0028; overall survival, 33.3% v 83.2%; P < .0001) as did patients with FP-RMS (event-free survival, 37% v 70%; P = .045; overall survival, 39.2% v 75%; P = .023). In multivariable analysis, ctDNA was independently associated with worse prognosis in FN-RMS but not in the smaller FP-RMS cohort. CONCLUSION Our study demonstrates that baseline ctDNA detection is feasible and is prognostic in IR RMS.
Extended Survival in Patients With Non–Small-Cell Lung Cancer–Associated Brain Metastases in the Modern Era
Authors: Berger Assaf , Mullen Reed , Bernstein Kenneth , Alzate Juan Diego , Silverman Joshua S. , Sulman Erik P. , Donahue Bernadine R. , Chachoua Abraham , Shum Elaine , Velcheti Vamsidhar , Sabari Joshua , Golfinos John G. , Kondziolka Douglas 
Published: February 2023

BACKGROUND:
Brain metastases (BM) have long been considered a terminal diagnosis with management mainly aimed at palliation and little hope for extended survival. Use of brain stereotactic radiosurgery (SRS) and/or resection, in addition to novel systemic therapies, has enabled improvements in overall and progression-free (PFS) survival.

OBJECTIVE:
To explore the possibility of extended survival in patients with non–small-cell lung cancer (NSCLC) BM in the current era.

METHODS:
During the years 2008 to 2020, 606 patients with NSCLC underwent their first Gamma Knife SRS for BM at our institution with point-of-care data collection. We reviewed clinical, molecular, imaging, and treatment parameters to explore the relationship of such factors with survival.

RESULTS:
The median overall survival was 17 months (95% CI, 13-40). Predictors of increased survival in a multivariable analysis included age <65 years (P < .001), KPS ≥80 (P < .001), absence of extracranial metastases (P < .001), fewer BM at first SRS (≤3, P = .003), and targeted therapy (P = .005), whereas chemotherapy alone was associated with shorter survival (P = .04). In a subgroup of patients managed before 2016 (n = 264), 38 (14%) were long-term survivors (≥5 years), of which 16% required no active cancer treatment (systemic or brain) for ≥3 years by the end of their follow-up.

CONCLUSION:
Long-term survival in patients with brain metastases from NSCLC is feasible in the current era of SRS when combined with the use of effective targeted therapeutics. Of those living ≥5 years, the chance for living with stable disease without the need for active treatment for ≥3 years was 16%.
Using self-supervised feature learning to improve the use of pulse oximeter signals to predict paediatric hospitalization
Authors: Mwaniki Paul , Kamanu Timothy , Akech Samuel , Dunsmuir Dustin , Ansermino J. Mark , Eijkemans M.J.C 
Published: February 2023

Background: The success of many machine learning applications depends on knowledge about the relationship between the input data and the task of interest (output), hindering the application of machine learning to novel tasks. End-to-end deep learning, which does not require intermediate feature engineering, has been recommended to overcome this challenge but end-to-end deep learning models require large labelled training data sets often unavailable in many medical applications. In this study, we trained self-supervised learning (SSL) models for automatic feature extraction from raw photoplethysmography (PPG) obtained using a pulse oximeter, with the aim of predicting paediatric hospitalization. Methods: We compared logistic regression models fitted using features extracted using SSL with models trained using both clinical and SSL features. In addition, we compared end-to-end deep learning models initialized randomly or using weights from the SSL models. We also compared the performance of SSL models trained on labelled data alone (n=1,031) with SSL trained using both labelled and unlabelled signals (n=7,578). Results: Logistic regression models were more predictive of hospitalization when trained on features extracted using labelled PPG signals only compared to SSL models trained on both labelled and unlabelled signals (AUC 0.83 vs 0.80). However, features extracted using SSL model trained on both labelled and unlabelled PPG signals were more predictive of hospitalization when concatenated with clinical features (AUC 0.89 vs 0.87). The end-to-end deep learning model had an AUC of 0.80 when initialized using the SSL model trained on all PPG signals, 0.77 when initialized using SSL trained on labelled data only, and 0.73 when initialized randomly. Conclusions: This study shows that SSL can extract features from PPG signals that are predictive of hospitalization or initialize end-to-end deep learning models. Furthermore, SSL can leverage larger unlabelled data sets to improve performance of models fitted using small labelled data sets.
Fertility Response to the COVID-19 Pandemic in Developed Countries – On Pre-pandemic Fertility Forecasts
Authors: Vanella Patrizio , Greil Arthur L. , Deschermeier Philipp 
Published: February 2023

The COVID-19 pandemic has affected all areas of our lives. Among other outcomes, the academic literature and popular media both discuss the potential effects of the pandemic on fertility. As fertility is an important determinant of population development and population forecasts are important for policy decisions and planning, we need to address to which extent fertility forecasts performed before the pandemic still apply.
Using Monte Carlo forecasting based on principal components of fertility rates, we quantify the effects of the pandemic on fertility for 22 countries and discuss whether forecasts made prior to the pandemic need adjustment based on more recent data.
Among the studied countries, 14 countries show no significant effect of the pandemic at all, while six countries have significantly lowered numbers of births in comparison to counterfactual trajectories that assume that past trends will hold. These countries are primarily in the Mediterranean and East Asia. For Finland and South Korea, there is statistical evidence for increased fertility in the early phases of the pandemic. In all cases with statistically significant fertility differentials caused by the pandemic, reproductive behavior normalized quickly. Therefore, we find no evidence for long-term effects of the pandemic on fertility, leading to the conclusion that pre-pandemic fertility forecasts still apply.
Avaliação de programa de atividade física para escolares: desenvolvimento e validação de instrumento
Authors: Silva Jaqueline Aragoni , Barbosa Filho Valter Cordeiro , Leal Danielle Biazzi , Squarcini Camila Fabiana Rossi , Silva Kelly Samara da 
Published: February 2023

Este estudo objetiva desenvolver e validar um instrumento para avaliar dimensões do planejamento e processo de implementação de um programa de intervenção voltado à promoção de atividade física em escolares. Foi conduzido um estudo metodológico realizado durante os meses de julho a dezembro de 2016, vinculado ao programa de intervenção intitulado de “Movimente”. O estudo envolveu as fases teórica (construção do instrumento), empírica e analítica (validação de conteúdo por especialistas, com atribuição de pontuação para os itens e de semântica, por membros da comunidade escolar e alunos do 7º ao 9º ano). O instrumento é dividido em duas dimensões: planejamento e processo. Resultados mostram que a dimensão de planejamento foi composta por indicadores acerca da importância da discussão sobre temas de saúde no contexto escolar, interesse em participar do programa e de suas respectivas ações. A dimensão de processo englobou indicadores sobre conhecimento e avaliação do programa e de suas respectivas ações, bem como sobre o interesse em manter o mesmo. Todas as questões foram consideradas válidas (índices de validade acima de 0,90) e compreensíveis (escores acima de 0,82). Conclui-se que o instrumento apresentou qualidade satisfatória no que diz respeito a validade de conteúdo e semântica, sendo considerado apropriado para avaliação do Programa Movimente e programas e ou projetos similares.
Winners from Winners: A Tale of Risk Factors
Authors: Chib Siddhartha , Zhao Lingxiao , Zhou Guofu 
Published: February 2023

Starting from twelve distinct factors from the recent literature, plus twelve principal components (PCs) of anomalies unexplained by the initial factors, a Bayesian comparison of approximately seventeen million models in terms of marginal likelihoods and posterior model probabilities shows that {Mkt, MOM, IA, ROE, MGMT, PERF, PEAD, FIN}, plus the nonconsecutive principal components, {[Formula: see text]} are the best supported risk factors. Pricing tests and annualized out-of-sample Sharpe ratios for tangency portfolios suggest that this asset pricing model should be used for computing expected returns, assessing investment strategies and building portfolios. This paper was accepted by Lukas Schmid, finance. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2023.4668 .
Investigating antenatal pelvic floor training using a vaginal balloon device in Czech women
Authors: Fousek Karel , Mrkvova Katerina , Branna Tereza , Ozana Marek 
Published: February 2023

Background/Aims A vaginal balloon device for antenatal pelvic floor training may reduce the incidence of negative outcomes from vaginal birth on women's pelvic health. This study's aims were to investigate the effect of antenatal vaginal training on birth-induced levator ani muscle avulsion and to analyse the relationship between use of a balloon device for training and the duration of the second stage of labour, incidence of episiotomy and birth-induced perineal trauma. Methods In this prospective cohort intervention study, 123 nulliparous women were divided into two groups: 64 training with the device antenatally (intervention) and 59 women receiving normal antenatal care (control). Clinical data were collected 10 weeks after birth and differences in the incidence of levator ani muscle avulsion, episiotomy, perineal tears and other birth injuries, as well as the duration of the second stage of labour, were assessed using two-tailed tests. Results Training with the device was not associated with a reduction in the incidence of levator ani muscle avulsions (P=0.82), and the device did not shorten the duration of the second stage of labour (P=0.63). However, it was associated with a reduction in the frequency of episiotomies (cases: 34% vs controls: 59%; P=0.007). There was no significant difference in the incidence of perineal tears (P=1.00) or other birth injuries (P=0.50). An obstetric anal sphincter injury occurred in only one case, in a woman in the control group. Conclusions The use of an antenatal training device in nulliparous women with cephalic vaginal birth at term is not associated with better pelvic health outcomes. However, it may reduce the frequency of episiotomies.
A multicentre comparative analysis of fixation versus revision surgery for periprosthetic femoral fractures following total hip arthroplasty with a cemented polished taper-slip femoral component
Authors: Jain Sameer , Farook Mohamed Z. , Aslam-Pervez Nayef , Amer Mohammad , Martin Damien H. , Unnithan Ashwin , Middleton Robert , Dunlop Douglas G. , Scott Chloe E. H. , West Robert , Pandit Hemant 
Published: February 2023

Aims The aim of this study was to compare open reduction and internal fixation (ORIF) with revision surgery for the surgical management of Unified Classification System (UCS) type B periprosthetic femoral fractures around cemented polished taper-slip femoral components following primary total hip arthroplasty (THA). Methods Data were collected for patients admitted to five UK centres. The primary outcome measure was the two-year reoperation rate. Secondary outcomes were time to surgery, transfusion requirements, critical care requirements, length of stay, two-year local complication rates, six-month systemic complication rates, and mortality rates. Comparisons were made by the form of treatment (ORIF vs revision) and UCS type (B1 vs B2/B3). Kaplan-Meier survival analysis was performed with two-year reoperation for any reason as the endpoint. Results A total of 317 periprosthetic fractures (in 317 patients) with a median follow-up of 3.6 years (interquartile range (IQR) 2.0 to 5.4) were included. The fractures were type B1 in 133 (42.0%), B2 in 170 (53.6%), and B3 in 14 patients (4.4%). ORIF was performed in 167 (52.7%) and revision in 150 patients (47.3%). The two-year reoperation rate (15.3% vs 7.2%; p = 0.021), time to surgery (4.0 days (IQR 2.0 to 7.0) vs 2.0 days (IQR 1.0 to 4.0); p < 0.001), transfusion requirements (55 patients (36.7%) vs 42 patients (25.1%); p = 0.026), critical care requirements (36 patients (24.0%) vs seven patients (4.2%); p < 0.001) and two-year local complication rates (26.7% vs 9.0%; p < 0.001) were significantly higher in the revision group. The two-year rate of survival was significantly higher for ORIF (91.9% (standard error (SE) 0.023%) vs 83.9% (SE 0.031%); p = 0.032) compared with revision. For B1 fractures, the two-year reoperation rate was significantly higher for revision compared with ORIF (29.4% vs 6.0%; p = 0.002) but this was similar for B2 and B3 fractures (9.8% vs 13.5%; p = 0.341). The most common indication for reoperation after revision was dislocation (12 patients; 8.0%). Conclusion Revision surgery has higher reoperation rates, longer surgical waiting times, higher transfusion requirements, and higher critical care requirements than ORIF in the management of periprosthetic fractures around polished taper-slip femoral components after THA. ORIF is a safe option providing anatomical reconstruction is achievable. Cite this article: Bone Joint J 2023;105-B(2):124–134.
The language of knee alignment
Authors: MacDessi Samuel J. , Oussedik Sam , Abdel Matthew P. , Victor Jan , Pagnano Mark W. , Haddad Fares S. 
Published: February 2023

Orthopaedic surgeons are currently faced with an overwhelming number of choices surrounding total knee arthroplasty (TKA), not only with the latest technologies and prostheses, but also fundamental decisions on alignment philosophies. From ‘mechanical’ to ‘adjusted mechanical’ to ‘restricted kinematic’ to ‘unrestricted kinematic’ — and how constitutional alignment relates to these — there is potential for ambiguity when thinking about and discussing such concepts. This annotation summarizes the various alignment strategies currently employed in TKA. It provides a clear framework and consistent language that will assist surgeons to compare confidently and contrast the concepts, while also discussing the latest opinions about alignment in TKA. Finally, it provides suggestions for applying consistent nomenclature to future research, especially as we explore the implications of 3D alignment patterns on patient outcomes. Cite this article: Bone Joint J 2023;105-B(2):102–108.
Higher knee survivorship in young patients with monocompartmental osteoarthritis and constitutional deformity treated by high tibial osteotomy then total knee arthroplasty compared to an early total knee arthroplasty
Authors: Erard Julien , Schmidt Axel , Batailler Cecile , Shatrov Jobe , Servien Elvire , Lustig Sébastien 
Published: February 2023

Aims The use of high tibial osteotomy (HTO) to delay total knee arthroplasty (TKA) in young patients with osteoarthritis (OA) and constitutional deformity remains debated. The aim of this study was to compare the long-term outcomes of TKA after HTO compared to TKA without HTO, using the time from the index OA surgery as reference (HTO for the study group, TKA for the control group). Methods This was a case-control study of consecutive patients receiving a posterior-stabilized TKA for OA between 1996 and 2010 with previous HTO. A total of 73 TKAs after HTO with minimum ten years’ follow-up were included. Cases were matched with a TKA without previous HTO for age at the time of the HTO. All revisions were recorded. Kaplan-Meier survivorship analysis was performed using revision of metal component as the endpoint. The Knee Society Score, range of motion, and patient satisfaction were assessed. Results Mean follow-up was 13 years (SD 3) after TKA in both groups. The 20-year Kaplan-Meier survival estimate was 98.6% in TKA post-HTO group (HTO as timing reference) and 81.4% in control group (TKA as timing reference) (p = 0.030). There was no significant difference in clinical outcomes, radiological outcomes, and complications at the last follow-up. Conclusion At the same delay from index surgery (HTO or TKA), a strategy of HTO followed by TKA had superior knee survivorship compared to early TKA at long term in young patients. Level of evidence: III Cite this article: Bone Jt Open 2023;4(2):62–71.
Enabling hierarchical control of coherent pluggable transceivers in SONiC packet–optical nodes
Authors: Giorgetti Alessio , Scano Davide , Sgambelluri Andrea , Paolucci Francesco , Riccardi Emilio , Morro Roberto , Castoldi Piero , Cugini Filippo 
Published: February 2023

Traditional metro networks are composed of packet switching nodes (i.e., routers) interconnected by optical transport links. In this scenario, the packet and optical domains are clearly separated, using dedicated controllers. Standalone muxponders/transponders will be replaced in optical metro and transport networks by the utilization of hybrid packet–optical nodes equipped with coherent pluggable transceivers. Thus, the traditional packet control plane is unable to manage and fully support the specific optical parameters required to configure such pluggable modules. Moreover, the coordination between the optical and packet layers within this hybrid node has not been standardized yet and requires careful design to enable effective management of connectivity services. This paper proposes two software-defined networking (SDN)-based hierarchical solutions to coordinate and control coherent pluggable transceivers in a multi-layer network exploiting hybrid packet–optical nodes. The two solutions have been designed and validated focusing on the pluggable module configuration and the communication within the SDN hierarchical architecture. An experimental testbed including two packet–optical nodes, running an extended version of the open-source Software for Open Networking in the Cloud (SONiC) operating system, is deployed to show the effectiveness of the two solutions, with a deep analysis of the time required to set up end-to-end connections spanning the packet and optical domains.