bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factor prediction of severe postoperative acute kidney injury at stage 3 in patients with acute type A aortic dissection using thromboelastography
Authors: Guan Xin-Liang , Li Lei , Li Hai-Yang , Gong Ming , Zhang Hong-Jia , Wang Xiao-Long 
Published: February 2023

ObjectivePerioperative blood transfusions and postoperative drainage volume not only are the commonly recognized risk factors for acute kidney injury (AKI) but also are indirect indicators of coagulopathy in patients with acute type A aortic dissection (ATAAD). However, standard laboratory tests fail to accurately reflect and assess the overall coagulopathy profile in patients with ATAAD. Thus, this study aimed to explore the association between the hemostatic system and severe postoperative AKI (stage 3) in patients with ATAAD using thromboelastography (TEG).MethodsWe selected 106 consecutive patients with ATAAD who underwent emergency aortic surgery at Beijing Anzhen Hospital. All participants were categorized into the stage 3 and non-stage 3 groups. The hemostatic system was evaluated using routine laboratory tests and TEG preoperatively. We undertook univariate and multivariate stepwise logistic regression analyses to determine the potential risk factors for severe postoperative AKI (stage 3), with a special investigation on the association between hemostatic system biomarkers and severe postoperative AKI (stage 3). The receiver operating characteristic (ROC) curves were generated to assess the predictive ability of hemostatic system biomarkers for severe postoperative AKI (stage 3).ResultsA total of 25 (23.6%) patients developed severe postoperative AKI (stage 3), including 21 patients (19.8%) who required continuous renal replacement therapy (RRT). Multivariate logistic regression analysis demonstrated that the preoperative fibrinogen level (OR, 2.02; 95% CI, 1.03 to 3.00; p = 0.04), platelet function (MA level) (OR, 1.23; 95% CI, 1.09 to 1.39; p = 0.001), and cardiopulmonary bypass (CPB) time (OR, 1.01; 95% CI, 1.00 to 1.02; p = 0.02) were independently associated with severe postoperative AKI (stage 3). The cutoff values of preoperative fibrinogen and platelet function (MA level) for predicting severe postoperative AKI (stage 3) were determined to be 2.56 g/L and 60.7 mm in the ROC curve [area under the curve (AUC): 0.824 and 0.829; p &lt; 0.001].ConclusionsThe preoperative fibrinogen level and platelet function (measured by the MA level) were identified as potential predictive factors for developing severe postoperative AKI (stage 3) in patients with ATAAD. Thromboelastography could be considered a potentially valuable tool for real-time monitoring and rapid assessment of the hemostatic system to improve postoperative outcomes in patients.
Comparison of in-hospital outcomes and long-term survival for valve-in-valve transcatheter aortic valve replacement versus the benchmark native valve transcatheter aortic valve replacement procedure
Authors: Matta Anthony , Levai Laszlo , Roncalli Jerome , Elbaz Meyer , Bouisset Frederic , Nader Vanessa , Blanco Stephanie , Campelo Parada Francisco , Carrié Didier , Lhermusier Thibault 
Published: February 2023

BackgroundIn recent years, the number of patients with failed surgically implanted aortic bioprostheses and the number of candidates for valve-in-valve transcatheter aortic valve replacement (VIV-TAVR) have been increasing.ObjectivesThe purpose of this study is to evaluate the efficacy, safety, and long-term survival outcomes of VIV-TAVR compared with the benchmark native valve transcatheter aortic valve replacement (NV-TAVR).MethodsA cohort study was conducted on patients who underwent TAVR in the department of cardiology at Toulouse University Hospital, Rangueil, France between January 2016 and January 2020. The study population was divided into two groups: NV-TAVR (N = 1589) and VIV-TAVR (N = 69). Baseline characteristics, procedural data, in-hospital outcomes, and long-term survival outcomes were observed.ResultsIn comparison with NV-TAVR, there are no differences in TAVR success rate (98.6 vs. 98.8%, p = 1), per-TAVR complications (p = 0.473), and length of hospital stay (7.5 ± 50.7 vs. 4.4 ± 2.8, p = 0.612). The prevalence of in-hospital adverse outcomes did not differ among study groups, including acute heart failure (1.4 vs. 1.1%), acute kidney injury (2.6, 1.4%), stroke (0 vs. 1.8%, p = 0.630), vascular complications (p = 0.307), bleeding events (0.617), and death (1.4 vs. 2.6%). VIV-TAVR was associated with a higher residual aortic gradient [OR = 1.139, 95%CI (1.097–1.182), p = 0.001] and a lower requirement for permanent pacemaker implantation [OR = 0.235 95%CI (0.056–0.990), p = 0.048]. Over a mean follow-up period of 3.44 ± 1.67 years, no significant difference in survival outcomes has been observed (p = 0.074).ConclusionVIV-TAVR shares the safety and efficacy profile of NV-TAVR. It also represents a better early outcome but a higher non-significant long-term mortality rate.
Trends in using of antihypertensive medication among US CKD adults, NHANES 2001–2018
Authors: Li Fanghua , Sun Anbang , Wu Feng , Zhang Dongshan , Zhao Zhanzheng 
Published: February 2023

ObjectiveBlood pressure (BP) control rates among adult patients taking antihypertensive medications in the United States have not improved over the last decade. Many CKD adults require more than one class of antihypertensive agent to reach the BP target recommended by the guidelines. However, no study has quantified the proportion of adult CKD patients taking antihypertensive medication who are on monotherapy or combination therapy.MethodsNational Health and Nutrition Examination Survey data during 2001-2018 was used, including adults with CKD taking antihypertensive medication (age ≥ 20 years, n = 4,453). BP control rates were investigated under the BP targets recommended by the 2021 KDIGO, the 2012 KDIGO, and the 2017 ACC/AHA guidelines.ResultsThe percentages of uncontrolled BP among US adults with CKD taking antihypertensive medication were 81.4% in 2001-2006 and 78.2% in 2013-2018. The proportion of monotherapy of antihypertensive regimen were 38.6, 33.3, and 34.6% from 2001 to 2006, 2007-2012, and 2013-2018, with no obvious difference. Similarly, there was no significant change in percentages of dual-therapy, triple-therapy, and quadruple-therapy. Although proportion of CKD adults not treated with ACEi/ARB decreased from 43.5% in 2001-2006 to 32.7% in 2013-2018, treatment of ACEi/ARB among patients with ACR &gt; 300 mg/g had no significant change.ConclusionThe BP control rates among US adult CKD patients taking antihypertensive medications have not improved from 2001 to 2018. Mono-therapy accounted for about one third of adult CKD patients taking antihypertensive medication and not changed. Increasing antihypertensive medication combination therapy may help improve BP control in CKD adults in the United States.
Development of a feasible and acceptable digital prehabilitation pathway to improve elective surgical outcomes
Authors: Linedale Ecushla C. , Bills Eleanor , Dimopoulos Anastasia , Yeoh Jackie , Nolan Mandy , Hume Vicki , Coles Sharyn , Andrews Jane M. 
Published: February 2023

Objective(s)To codesign and assess the feasibility, acceptability, and appropriateness of a hospital-initiated, community delivered approach to health optimization (prehab) prior to planned surgery.DesignParticipatory codesign combined with a prospective, observational cohort study (April–July 2022).SettingA large metropolitan tertiary referral service with 2 participating hospitals.ParticipantsAll people referred for orthopaedic assessment for joint replacement surgery (hip or knee) triaged as category 2 or 3. Exclusions: category 1; no mobile number. Response rate 80%.InterventionMy PreHab Program is a digitally enabled pathway that screens participants for modifiable risk factors for post-operative complications and provides tailored information to enable health optimization prior to surgery with the help of their regular doctor.Outcome measuresAcceptability, feasibility, appropriateness, and engagement with the program.Results36/45 (80%) registered for the program (ages 45–85 yrs.), completed the health-screening survey and had ≥1 modifiable risk factor. Eighteen responded to the consumer experience questionnaire: 11 had already seen or scheduled an appointment with their General Practitioner and 5 planned to. 10 had commenced prehab and, 7 planned to. Half indicated they were likely (n = 7) or very likely (n = 2) to recommend My PreHab Program to others. The My PreHab Program scored an average 3.4 (SD 0.78) for acceptability, 3.5 (SD 0.62) for appropriateness, and 3.6 (SD 0.61) for feasibility, out of a score of 5.Conclusion(s)This digitally delivered intervention is acceptable, appropriate, and feasible to support a hospital-initiated, community-based prehab program.
Geological characteristics and gas-bearing evaluation of coal-measure gas reservoirs in the Huanghebei coalfield
Authors: Shao Yubao , Wang Huaihong , Guo Yinghai , Huang Xinglong , Wang Yongjun , Zhao Shushan , Zhu Yuzhen , Shen Lijun , Huang Xin , Song Yu , Wang Ming , Cui Kai , Yang Qidong 
Published: February 2023

Bystudying the source reservoir geochemical characteristics, reservoir cap physical properties, gas-bearing characteristics and reservoir-forming types of the coal-measure gas (CMG) accumulation system, the potential of CMG resources in the Huanghebei Coalfield was determined, and the sedimentary reservoir control mechanism was analyzed, which is of great significance for the orderly development of CMG reservoirs. CMG in the Huanghebei Coalfield mainly includes abundant shale gas (SG; 2100.45 × 108 m3), coalbed methane (CBM; 137.89 × 108 m3) and a small amount of tight sandstone gas, limestone gas and magmatic rock gas. CMG rocks mainly include shale and coal seams of the marine–terrestrial transitional facies Taiyuan Formation and continental facies Shanxi Formation, providing a favorable material basis for CMG enrichment. The coal seams are largely mature to highly mature, with satisfactory hydrocarbon generation potential and reservoir connectivity. They are low-porosity, low-permeability, underpressurized and undersaturated reservoirs. The shale organic matter is primarily Type II, with a moderate organic matter abundance. The material is at the middle-to high-maturity stage, provides a suitable hydrocarbon generation potential, belongs to low-porosity and low-permeability reservoirs, and exhibits favorable fracturing properties. There are several stable and independent gas-bearing systems among the coal measures. The CMG accumulation combination types are mostly self-sourced gas reservoirs and self-sourced+other-source near-source gas reservoirs, followed by other-source gas reservoirs. CBM and SG play the role of vertical regulation and horizontal regulation, respectively.
New insights on the cardiovascular effects of IGF-1
Authors: Macvanin Mirjana , Gluvic Zoran , Radovanovic Jelena , Essack Magbubah , Gao Xin , Isenovic Esma R. 
Published: February 2023

IntroductionCardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV healthMethodsWe searched PubMed and MEDLINE for English and non-English articles with English abstracts published between 1957 (when the first report on IGF-1 identification was published) and 2022. The top search terms were: IGF-1, cardiovascular disease, IGF-1 receptors, IGF-1 and microRNAs, therapeutic interventions with IGF-1, IGF-1 and diabetes, IGF-1 and cardiovascular disease. The search retrieved original peer-reviewed articles, which were further analyzed, focusing on the role of IGF-1 in pathophysiological conditions. We specifically focused on including the most recent findings published in the past five years.ResultsIGF-1, an anabolic growth factor, regulates cell division, proliferation, and survival. In addition to its well-known growth-promoting and metabolic effects, there is mounting evidence that IGF-1 plays a specialized role in the complex activities that underpin CV function. IGF-1 promotes cardiac development and improves cardiac output, stroke volume, contractility, and ejection fraction. Furthermore, IGF-1 mediates many growth hormones (GH) actions. IGF-1 stimulates contractility and tissue remodeling in humans to improve heart function after myocardial infarction. IGF-1 also improves the lipid profile, lowers insulin levels, increases insulin sensitivity, and promotes glucose metabolism. These findings point to the intriguing medicinal potential of IGF-1. Human studies associate low serum levels of free or total IGF-1 with an increased risk of CV and cerebrovascular illness. Extensive human trials are being conducted to investigate the therapeutic efficacy and outcomes of IGF-1-related therapy.DiscussionWe anticipate the development of novel IGF-1-related therapy with minimal side effects. This review discusses recent findings on the role of IGF-1 in the cardiovascular (CVD) system, including both normal and pathological conditions. We also discuss progress in therapeutic interventions aimed at targeting the IGF axis and provide insights into the epigenetic regulation of IGF-1 mediated by microRNAs.
Cardiovascular disease, associated risk factors, and risk of dementia: An umbrella review of meta-analyses
Authors: Brain Jacob , Greene Leanne , Tang Eugene Y. H. , Louise Jennie , Salter Amy , Beach Sarah , Turnbull Deborah , Siervo Mario , Stephan Blossom C. M. , Tully Phillip J. 
Published: February 2023

IntroductionCardiovascular diseases (CVDs) have been associated with an increased risk of dementia; yet the evidence is mixed. This review critically appraises and synthesises current evidence exploring associations between dementia risk and CVD and their risk factors, including coronary heart disease, heart failure, atrial fibrillation, hypertension, hyperlipidaemia, and arterial stiffness.MethodsMEDLINE, Embase, PsycINFO, and the Cochrane Database of Systematic Reviews were searched to identify systematic reviews with meta-analyses investigating the association between at least one of the CVDs of interest and dementia risk. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Systematic Reviews was used to assess methodological quality.ResultsTwenty-five meta-analyses published between 2007 and 2021 were included. Studies largely consisted of cohorts from North America and Europe. Findings were variable, with coronary heart disease, heart failure, and atrial fibrillation consistently associated with increased risk for all-cause dementia, but results were inconsistent for Alzheimer's disease. Hypertension was more frequently associated with dementia during mid-life compared to late life. Findings concerning cholesterol were complex, and while results were inconsistent for low-density lipoprotein cholesterol and total cholesterol, there appeared to be no associations between triglycerides and high-density lipoprotein cholesterol. All meta-analyses investigating hypercholesterolaemia showed significant increases in dementia risk. There was a paucity of research on the association between arterial stiffness and dementia risk.ConclusionTargeted CVD dementia prevention strategies could reduce dementia prevalence. Future research should determine the underpinning mechanisms linking heart and brain health to determine the most effective strategies for dementia risk reduction in CVD populations.
Expression of HSPA14 in patients with acute HIV-1 infection and its effect on HIV-1 replication
Authors: Bi Mingyuan , Kang Wen , Sun Yongtao 
Published: February 2023

IntroductionHeat shock protein (HSPs) are important intracellular factors, which are often involved in the regulation of viral replication including HIV-1 in infected individuals as molecular chaperone proteins. Heat shock proteins 70 (HSP70/HSPA) family play important roles in HIV replication, but this family contain many subtypes, and it is unclear how these subtypes participate in and affect HIV replication.MethodsTo detect the interaction between HSPA14 and HspBP1 by CO-IP. Simulating HIV infection status in vitro to detect the change of intracellular HSPA14 expression after HIV infection in different cells. Constructing HSPA14 overexpression or knockdown cells to detect intracellular HIV replication levels after in vitro infection. Detecting the difference of HSPA expression levels in CD4+ T cells of untreated acute HIV-infected patients with different viral load.ResultsIn this study, we found that HIV infection can lead to changes in the transcriptional level of many HSPA subtypes, among which HSPA14 interacts with HIV transcriptional inhibitor HspBP1. The expression of HSPA14 in Jurkat and primary CD4+T cells infected with HIV were inhibited, overexpression of HSPA14 inhibited HIV replication, while knocking down HSPA14 promoted HIV replication. We also found that the expression level of HSPA14 is higher in peripheral blood CD4+T cells of untreated acute HIV infection patients with low viral load.ConclusionHSPA14 is a potential HIV replication inhibitor and may restrict HIV replication by regulating the transcriptional inhibitor HspBP1. Further studies are needed to determine the specific mechanism by which HSPA14 regulates viral replication
Industry remotely operated vehicle imagery for assessing marine communities associated with subsea oil and gas infrastructure on the continental shelf of South-East Australia
Authors: Ierodiaconou Daniel , McLean Dianne , Birt Matthew Jon , Bond Todd , Wines Sam , Glade-Wright Ollie , Morris Joe , Higgs Doug , Whitmarsh Sasha K. 
Published: February 2023

Introduction Offshore oil and gas (O &amp; G) infrastructure provides hard substrata of structural complexity in marine environments and has been shown to have ecological value, particularly in oligotrophic environments. As infrastructure approaches end of life, understanding such values is critical to inform decommissioning decisions. MethodsThis study uses a decade of industry remotely operated vehicle (ROV) imagery to describe fish, invertebrate, and benthic communities on gas field infrastructure. Sampling was conducted over 22 km of flowline, three wells and one manifold in the temperate waters of Bass Strait, south east Australia in depths of 155 to 263 m.ResultsA total of 10,343 mobile animals from 69 taxa were observed. A higher diversity of fishes were observed on flowlines (28 taxa) compared to wells (19 taxa). Fish and invertebrate communities observed along flowlines were distinct from those observed on wells/manifold, however, there was also high spatial variability among the different flowlines surveyed and between the three wells and manifold. These differences appear to be driven by habitat and depth preferences of the species observed. Many sand-affiliated species were associated with buried sections of flowlines (Tasmanian giant crab Pseudocarcinus gigas, Balmain bug Ibacus peronii, slender sand burrower Creedia haswelli, red cod Pseudophycis spp., blue grenadier Macruronus novaezelandiae) whilst reef-associated and schooling species were observed on the wells/manifold (jackass morwong Nemadactylus macropterus, redbait Emmelichthys nitidus, splendid perch Callanthias australis). Species of ecological importance were also noted including the Australian fur seal (Arctocephalus pusillus doriferus), long-lived foxfish (Bodianus frenchii), and handfish (Brachionichthyidae spp).DiscussionThis study describes the habitat value of oil and gas infrastructure in a data poor temperate region that is important for understanding how the decommissioning of these structures may affect local marine ecosystems and fisheries. Therefore, it is critical to understand the habitat value of O&amp;G infrastructure to marine life in the Bass Strait and whether decommissioning of these structures affect local marine ecosystems and fisheries. This study shows the complexity of determining temporal change in biodiversity values associated with these O &amp; G structures from historical industry datasets that will be key for informing future decommissioning options. We also provide some guidance on how future quantitative data can be obtained in a systematic way using industry ROV data to better inform ecological investigations and decommissioning options.
Novel copper-containing ferrite nanoparticles exert lethality to MRSA by disrupting MRSA cell membrane permeability, depleting intracellular iron ions, and upregulating ROS levels
Authors: Ye Jinhua , Hou Fangpeng , Chen Guanyu , Zhong Tianyu , Xue Junxia , Yu Fangyou , Lai Yi , Yang Yingjie , Liu Dedong , Tian Yuantong , Huang Junyun 
Published: February 2023

ObjectiveThe widespread use of antibiotics has inevitably led to the emergence of multidrug-resistant bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA), making treatment of this infection a serious challenge. This study aimed to explore new treatment strategies for MRSA infection.MethodsThe structure of Fe3O4 NPs with limited antibacterial activity was optimized, and the Fe2+ ↔ Fe3+ electronic coupling was eliminated by replacing 1/2 Fe2+ with Cu2+. A new type of copper-containing ferrite nanoparticles (hereinafter referred to as Cu@Fe NPs) that fully retained oxidation–reduction activity was synthesized. First, the ultrastructure of Cu@Fe NPs was examined. Then, antibacterial activity was determined by testing the minimum inhibitory concentration (MIC) and safety for use as an antibiotic agent. Next, the mechanisms underlying the antibacterial effects of Cu@Fe NPs were investigated. Finally, mice models of systemic and localized MRSA infections was established for in vivo validation.ResultsIt was found that Cu@Fe NPs exhibited excellent antibacterial activity against MRSA with MIC of 1 μg/mL. It effectively inhibited the development of MRSA resistance and disrupted the bacterial biofilms. More importantly, the cell membranes of MRSA exposed to Cu@Fe NPs underwent significant rupture and leakage of the cell contents. Cu@Fe NPs also significantly reduced the iron ions required for bacterial growth and contributed to excessive intracellular accumulation of exogenous reactive oxygen species (ROS). Therefore, these findings may important for its antibacterial effect. Furthermore, Cu@Fe NPs treatment led to a significant reduction in colony forming units within intra-abdominal organs, such as the liver, spleen, kidney, and lung, in mice with systemic MRSA infection, but not for damaged skin in those with localized MRSA infection.ConclusionThe synthesized nanoparticles has an excellent drug safety profile, confers high resistant to MRSA, and can effectively inhibit the progression of drug resistance. It also has the potential to exert anti-MRSA infection effects systemically in vivo. In addition, our study revealed a unique multifaceted antibacterial mode of Cu@Fe NPs: (1) an increase in cell membrane permeability, (2) depletion of Fe ions in cells, (3) generation of ROS in cells. Overall, Cu@Fe NPs may be potential therapeutic agents for MRSA infections.