bluuebunny/crossref_metadata_2025_split huggingface dataset:
An approach to rapidly identify the gender of the pigeon by using cross-priming amplification with immune-chromatographic strip
Authors: Wang Yimin , Gao Yilin , Wang Shan , Li Hanglin , He Xun , Wang Wei , Ba Yierta , Wang Lei , Jiang Jinqing 
Published: March 2023

Abstract
Most of birds are monomorphic species and breeds, which makes it difficult to determine their gender by appearances, especially the pigeon is a farm animal with an economic interest in meat production, ornamentals, sports, and experimental animals. Until now, only endoscopy, laparoscopy, karyotyping, and DNA testing are available, but these methods are expensive, invasive, or time-consuming for the determination gender of the pigeon. Therefore, an easy, accurate, sensitive, on-site, affordable, and applicable rapid identification of the gender of the pigeon is widely needed for the owner of the pigeon. The purpose of this study was to develop and evaluate the efficacy of Cross-priming amplification (CPA) combined with an immune-chromatographic strip (CPA-strip) for gender identification of the pigeon. The methodology was optimized through various experimental trials. Subsequently, ten samples collected from pigeons were subjected to analysis using the optimized CPA-strip assay, and the results indicated that all female samples were accurately detected. In contrast, the blood samples collected from chickens and ducks were negative when tested with the CPA-strip assay. In conclusion, our study demonstrates the successful establishment of an immune-chromatographic CPA-strip assay for the on-site gender determination of pigeons with high accuracy.
Deposit morphology and structure under interactions of sliding mass and erodible layers—experimental insights
Authors: Yao Chaowei , Zhang Qing , Duan Zhao , Li Ming , Wu Yinbing , Wang Nianqin 
Published: March 2023

Abstract
Landslides are a kind of highly concerned geological disasters that occurring with complex motion processes and mechanisms. They often significantly affect the human life and properties located in their pathway. In some circumstances, the geological phenomena and structural features generated by the interactions between landslides and their substrates are still unclear, which makes it difficult to be forecasted and mitigated on its effects. In this study, a sandbox experiment was conducted to study the velocity and displacement of the sliding mass, the geometry of the deposit, and the internal and external structural characteristics of the deposit under the interactions between the sliding mass and erodible layer by varying the depth of the erodible layer. Results show that the motion process of sliding mass consists of three stages: falling, shovel push-extrusion, and push-nappe accumulation. In the first stage, the velocity of the sliding mass increases sharply to a peak velocity before colliding with the erodible layer. In the latter two stages, the mobility of landslide is greatly limited by the erodible layers at the foot of the inclined plate, and the secondary acceleration of the sliding mass is observed. The deposits were divided into three zones (Ia, Ib, and II), in terms of the morphological and structural characteristics of their positions. The action forms were mainly pushing and covering in the zone II and I respectively. There were phenomena such as strata inversion, pushover, and entrainment that occurred in the deposits; the folds, ridges, and bulge that occurred on the surface of deposits. These structural characteristics reflect the stress states of laboratory landslides in motion from compressing to shearing. The results of this research will provide a valuable theoretical reference for the calculation of the disaster range when erodible layers exist in landslides' motion paths.
Development of a longitudinal-torsional ultrasonic assisted roller dressing device for precision form grinding of GCr15 bearing rings
Authors: Li Chenglong , Jiao Feng , Ma Xiaosan , Niu Ying , Tong Jinglin 
Published: March 2023

Abstract
High-quality and highly precision dressing is essential to achieving precision form grinding of GCr15 bearing rings. A method of longitudinal-torsional ultrasonic assisted roller dressing (LTUARD) was proposed for achieving high precision and high-quality dressing. A device of LTUARD was developed for investigating the dressing effect of the longitudinal-torsional ultrasonic assisted roller on the white alumina (WA) grinding wheel. The longitudinal-torsional horn with roller loading was mainly studied during the device development of LTUARD. The geometric dimensions of the longitudinal vibration horn with large tool head were firstly determined by the set of transcendental equations, and then the longitudinal vibration was converted to longitudinal torsional vibration by adding a helical slot in the conical section. Subsequently, the results of the impedance analysis and vibration characteristics experiments of the longitudinal-torsional ultrasonic vibration system show that the vibration system meets the vibration requirements of LTUARD. The vitrified bonded white alumina (WA) grinding wheel dressing experiments were carried out using conventional roller dressing (CRD) and LTUARD respectively, and the grinding of GCr15 bearing rings with the before dressing (BD) and after dressing of WA grinding wheel. The results of dressing and grinding experiments show that the surface morphology and roundness error of WA grinding wheel are improved after LTUARD, and the surface quality of GCr15 bearing rings ground by WA grinding wheel after LTUARD dressing is better. The reliability and practicality of the developed dressing device were verified by the dressing and grinding experiment results.
A novel in vitro model of long-lasting inflammation using primary human macrophages for osteoarthritis research
Authors: Ummarino Aldo , Pensado-López Alba , Migliore Roberta , Alcaide-Ruggiero Lourdes , Calà Nicholas , Caputo Michele , Gambaro Francesco Manlio , Anfray Clément , Ronzoni Flavio L. , Kon Elizaveta , Allavena Paola , Andón Fernando Torres 
Published: March 2023

Abstract
Background. Development of pre-clinical models of long-lasting inflammation is needed for the study of inflammatory diseases. Osteoarthritis (OA), the most common inflammatory joint pathology, is characterized by an abundance of M1-like macrophages producing several pro-inflammatory cytokines and proteolytic enzymes damaging the local tissues. Here we developed a novel in vitro model of long-lasting inflammation using primary human monocyte-derived macrophages continuously cultured for 15 days.
Results. We first screened synovial fluids from 11 OA patients using multiplex Ella® and we found measurable levels of IL-6, CCL2, CCL5, CXCL8, CXCL10, TNFa, IL-1b, using them as read-outs of the following experiments. We then found an increased survival of macrophages differentiated with both M-CSF and GM-CSF (M-/GM-Mf) compared either with macrophages differentiated with M-CSF alone (M-Mf) or macrophages differentiated with GM-CSF alone (GM-Mf) and, consequently, decided to use them to set up the in vitro model of long-lasting inflammation. Consistently with the increased survival, the repeated stimulation of M-/GM-Mfs either with lipopolysaccharide + interferon-g (LPS+IFN-g) or Pam3CysSerLys4 (Pam3CSK4) led to the sustained production of IL-6, CCL2 and CXCL8 over time. Finally, to investigate the usefulness of our model for OA research, we repeatedly exposed stimulated macrophages to dexamethasone (DEX) and/or celecoxib (CEL), two anti-inflammatory drugs commonly used for OA therapy. We found an excellent anti-inflammatory activity but significant toxicity of DEX for concentrations over 10 nM, while CEL was not toxic and efficiently inhibited PGE2 secretion. Of interest, the inflammatory profile of macrophages differentiated with M-CSF or GM-CSF and activated with the two pro-inflammatory stimuli (LPS+IFN-g vs Pam3CSK4) was not identical, overall showing production of more inflammatory mediators with GM-CSF-macrophages stimulated with Pam3CSK4.
Conclusions. We introduce here a novel easy-to-use in vitro culture model of long-lasting inflammation using primary human macrophages, that could be useful for the screening of new compounds and drug delivery systems, to improve the therapy of inflammatory disorders.
Economic Evaluation of Cefiderocol for the Treatment of Carbapenem- Resistant Infections in Italy
Authors: Bassetti Matteo , Pitrelli Andrea , Notarianni Maria Laura , Green Will , Dymond Amy , Gill Karan 
Published: March 2023

Abstract
Background
Antimicrobial resistance (AMR) has become an increasing concern to healthcare systems worldwide and is currently recognised as a major urgent threat to public health. In 2017, the World Health Organisation (WHO) specifically highlighted the threat of gram-negative bacteria resistant to multiple antibiotics, specifying three ‘Priority 1 – Critical’, carbapenem-resistant (CR) pathogens for which drugs are urgently required to address. Cefiderocol, a parenteral antibiotic, is the first antibiotic to address all three priority 1 pathogens described by the WHO.
Methods
A decision-tree model was built to determine the cost-effectiveness of cefiderocol vs colistin and colistin based regimens, for the treatment of seriously ill patients with a confirmed CR infection in Italy. A scenario analysis was also run comparing the cost-effectiveness of cefiderocol with ceftazidime/avibactam for the treatment of seriously ill patients with a suspected CR infection. The evaluation was performed from a health care perspective with a lifetime time horizon. Deterministic and probabilistic sensitivity analyses were also conducted to account for uncertainty.
Results
Cefiderocol was shown to be cost-effective when compared with colistin and colistin based regimens in the confirmed CR population at a cost-effectiveness threshold of €40,000, with an incremental cost-effectiveness ratio of €11,430 and incremental net monetary benefit of €18,751. The probabilistic sensitivity analysis results in a probability of cost-effectiveness of 70.1% and the probability of a sustained cure was the main driver of the economic model. Cefiderocol was also cost-effective in the suspected CR population.
Conclusions
Cefiderocol is cost-effective from the Italian health care perspective when used to treat seriously ill patients with both confirmed, and suspected, CR infections.
TP53 mutation-associated immunosignatures impact on anti-PD-L1 treatment response in head and neck cancer patients.
Authors: Sacconi Andrea , Muti Paola , Pulito Claudio , Pellini Raul , Strano Sabrina , Ben-David Uri , Bossi Paolo , Blandino Giovanni 
Published: March 2023

Abstract
Background. Immune checkpoint inhibitors (ICIs) are a therapeutic strategy for various cancers although only a subset of patients respond to the therapy. Identifying patients more prone to respond to ICIs may increase the therapeutic benefit and allow studying new approaches for resistant patients.
Methods. We analyzed the TCGA cohort of HNSCC patients in relation to their activation of 26 immune gene expression signatures, as well as their cell typecomposition, in order to define signaling pathways associated with resistance to ICIs. Results were validated on a cohort of 102 HNSCC patients under treatment with PD-L1 inhibitors and by in vitro experiments in HNSCC cell lines.
Results. We observed a significant association between the gene set and TP53 gene status and other predictors of the response to ICI in HNSCC patients. Surprisingly, the presence of a TP53 mutation together with another co-driver mutation was associated with significantly higher levels of the immune gene expression, in comparison to tumors in which the TP53 gene was mutated alone. In addition, the higher level of TP53 mutated-dependent MYC signature was associated with lower levels of the immune gene expression signature. In vitro and a patient cohort validation corroborated these findings.
Conclusions. Immune gene signature sets may classify with more accuracy HNSCC patients responsive to immunotherapy. These biomarkers may be easily implemented in clinical setting.
Probing the sensitivity of ab initio multiple spawning to its parameters
Authors: Lassmann Yorick , Curchod Basile 
Published: March 2023

Abstract
Full multiple spawning (FMS) offers a strategy to simulate the nonadiabatic dynamics of molecular systems by describing their nuclear wavefunctions by a linear combination of coupled trajectory basis functions (TBFs). Applying a series of controlled approximations to the FMS equations leads to the ab initio multiple spawning (AIMS), which is compatible with an on-the-fly propagation of the TBFs and an accurate description of nonadiabatic processes. The AIMS strategy and its numerical implementations, however, rely on a series of user-defined parameters. Herein, we investigate the influence of these parameters on the electronic-state population of two molecular systems – trans-azomethane and a two-dimensional model of the butatriene cation. This work highlights the stability of AIMS with respect to most of its parameters, underlines the specific parameters that require particular attention from the user of the method, and offers prescriptions for an informed selection of their value.
Computing Balanced Solutions for Large International Kidney Exchange Schemes
Authors: Benedek Marton , Biró Péter , Paulusma Daniel , Ye Xin 
Published: March 2023

Abstract

To overcome incompatibility issues, kidney patients may swap their donors. In international kidney exchange programmes (IKEPs), countries merge their national patient-donor pools. We consider a recently introduced credit system. In each round, countries are given an initial ``fair'' allocation of the total number of kidney transplants. This allocation is adjusted by a credit function yielding a target allocation. The goal is to find a solution that approaches the target allocation as closely as possible, to ensure long-term stability of the international pool. As solutions, we use maximum matchings that lexicographically minimize the country deviations from the target allocation. We perform, for the first time, a computational study for a large number of countries. For the initial allocations we use two easy-to-compute solution concepts, the benefit value and the contribution value, and four classical but hard-to-compute concepts, the Shapley value, nucleolus, Banzhaf value and tau value. By using state-of-the-art software we show that the latter four concepts are now within reach for IKEPs of up to fifteen countries. Our experiments show that using lexicographically minimal maximum matchings instead of ones that only minimize the largest deviation from the target allocation (as previously done) may make an IKEP up to 54% more balanced.
An experiment of the light with contradictory formulas
Authors: Louiz Akram 
Published: March 2023

Abstract
Motivated by the appearance of my previous article about the light in the very useful Book titled the worldwide list of alternative theories and critics (edition 2023), I tried to propose this experiment that tries to trap light beams in a rotating environment.
I presented also the related formulas in this work and I could even guess some recurrence relations if the trapped Light-Beam is reflected several times from the moving wall of mirrors. However, the work exposes a contradiction concerning the reflected light beams velocity vectors and this made us suspect the correctness of some formulas when dealing with moving mirrors.
This proposed experiment is very interesting, but the most important are the remarks that can be made by observing the contradictions exposed in this article.
FSCN: A Novel Forwarding Method based on Shannon Entropy and COPRAS Decision Process in Named Data Networking
Authors: Soltani Mohammad , Barekatain Behrang , Hendesi Faramarz , Beheshti Zahra 
Published: March 2023

Abstract
One of the next-generation Information-Centric Networking (ICN) architectures for the future Internet is Named Data Networking (NDN). The appropriate output interface (forwarding) has recently emerged as a key challenge affecting the performance of this network and has received a lot of attention from researchers due to its importance. Although efforts have been made through the methods introduced so far to address this challenge, the neglect of effective network load balancing parameters, non-dynamic weighting, and the use of only a few criteria have been suggested for selecting the output interface have made it vital to further improve the network delay, congestion, and ultimately the network's throughput. Regarding this matter, a new strategy is presented in this article based on the COPRAS Decision-Making Process with the dynamic weighting of Shannon's entropy called FSCN for transmitting request packets through the optimal output interface. The essential parameters identified in the suggested approach such as bandwidth, delay, and the number of hops can be dynamically weighted using the Shannon entropy technique and conditions. Then, the interfaces are scored using the COPRAS method, and the suitable output interface is ascertained. The advantages of the proposed method include considering influential criteria to characterize the path's performance and the dynamic weighting of criteria. The simulation outcomes in NDNsim demonstrated enhancements in critical parameters, including interest throughput, satisfaction ratio, packet drop, and delivery time when compared to comparable approaches.
Total infectome of etiology and epidemiology unravels a complex infection landscape in Chinese acute diarrheal pig herds
Authors: Sun Yankuo , Xing Jiabao , Li Yue , Xu Sijia , Wang Zhiyuan , Lin Jinsen , Cao Xinyu , Zheng Zezhong , Gong Lang , Shi Mang , Zhang Guihong 
Published: March 2023

Abstract
Background
Porcine diarrhea is predominantly caused by infectious pathogens, leading to decreased appetite, poor digestion, intestinal inflammation, dysbiosis, and weight loss. These factors significantly affect productivity and performance in modern farming systems. However, the interactions between these pathogens and their temporal-spatial dynamics, as well as their interactions with other concurrent pathogens in multiorgan complex diseases, are rarely considered. Thus, understanding the relevant etiology of these clinical manifestations is crucial.
Results
To address this gap, we used a meta-transcriptomics approach to jointly characterize the prevalence, abundance, evolutionary history, and natural diversity of a wide spectrum of pathogens within 122 cases of acute diarrhea from different pig farms, including 47 mixed group samples involving other pathological tissues. We categorized the samples into two groups: "intestine only" and "mixed tissue." We identified 43 species of pathogenic microbes, consisting of 37 species of viruses and six species of prokaryotes that contribute putatively to clinical manifestations. Evolutionary estimation revealed a highly divergent evolutionary dynamic of important swine pathogens that was previously unknown. Diversity analysis revealed that seasonal turnover was a significant factor affecting the structure of enteric pathogen populations. Correlation analysis performed on gut-only samples provided insight into the synergistic relationship between enteric pathogens. Comparative analysis of the infectome against both sampling categories mapped the heterogeneity of the pathogenic community underlying multiorgan complex diseases.
Conclusion
In summary, our meta-transcriptomics approach revealed a complex infectome of porcine diarrhea, which threatens livestock and humans. It offers valuable prior knowledge of disease interactions for veterinarians prior to clinical diagnosis. Our findings may serve as a reference for understanding microbial communities and could inform disease prevention and control strategies.
Emotion dysregulation and social communication problems may predict severity of obsessive compulsive disorder symptoms among Turkish adolescents: A single-center, case-control study
Authors: Öztürk Yusuf , Özyurt Gonca , Turan Serkan , Tufan Ali Evren , Akay Aynur Pekcanlar 
Published: March 2023

Abstract

Studies have shown that theory of mind, emotion regulation and pragmatic abilities are negatively affected in people with OCD. We aimed to investigate ToM abilities, social responsiveness, pragmatic language, and emotion regulation skills in children with OCD, comparing them to healthy controls. This study was designed as a single-center, cross-sectional, case-control study. The participants were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS-PL) implemented by blinded professionals [32]. All participants fulfilled tests evaluating their ToM abilities via “Reading the Mind in the Eyes Test” (RMET), “Faces Test”, “Faux-Pas Test”, “Comprehension Test” and “Unexpected Outcomes Test”, Social Responsiveness Scale (SRS), Children’s Communication Checklist- Second Edition (CCC-2), Difficulties in Emotion Regulation Scale (DERS) and Yale-Brown Obsession Compulsion Scale (YBOCS). Within the study period, we enrolled 85 adolescents (42 with OCD and 43 controls). The CCC-2 scores except for CCC-2 coherence subscaleand SRS-2 scale total were found to be statistically significantly elevated in the OCD group than healthy controls (p < 0.05). The OCD group performed lower in the Faux Pass, Comprehension tests than the healthy controls (p = 0.003 for both). We found a statistically significant difference between both groups in terms of the goal, strategy, non-acceptance subscales of the DERS (p < 0.001, p = 0.006, p = 0.008, respectively) and the total score of DERS (p < 0.001). YBOCS total scores correlated significantly and negatively with Comprehension test, Faux Pas test, unexpected outcomes tests, and positively with CCC total, SRS total and DERS total scores and the DERS, SRS and CCC tests emerged as significant predictors of YBOCS total score. Adolescents diagnosed with OCD face difficulties in advanced level mentalizing, various domains of language and emotion regulation. Addressing ToM, pragmatic, and ER difficulties when planning the treatment of young people with OCD may make an additional contribution to treatment.
Mind the gap between English textbooks and test papers: a corpus-based discourse from Vietnam
Authors: Nguyen An 
Published: March 2023

Abstract
Alignment in between curriculum and assessment remains an important, yet underexplored, topic. This study critically investigates the content (mis)match between English textbooks and English exam papers in Vietnam. This study explores an open question, often claimed by the ministers as the goal of the education reforms: Does the English Examination closely follow what was set out in the current English textbooks, in terms of the lexical content? Through corpus-based discourse analysis, this study evaluates 6 English textbooks and 150 English past papers for upper secondary students in Vietnam for 3 years. Results show a downward trend in content alignment between English exam past papers and the English curriculum. A subsequent discussion of underlying causes is included, and recommendations are offered for future research.