bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical efficacy of intra-articular infusion of cocktail combined with tranexamic acid in the treatment of middle-age and older patients with frozen shoulder following arthroscopic capsular release
Authors: Bai Xiaojin , Bai Fan , Wang Zhi , Zhang Yan , Liu Fuying , Wang Qibing 
Published: May 2023

ObjectiveTo investigate the clinical efficacy of arthroscopic capsular release and postoperative intra-articular infusion of cocktail combined with tranexamic acid (TXA) in the treatment of patients with frozen shoulder.MethodA total of 85 middle-aged and older patients with frozen shoulder who underwent arthroscopic capsular release and received intra-articular infusion of TXA alone (n = 28), cocktail alone (n = 26), and cocktail plus TXA (n = 31) after surgery were retrospective analyzed. The drainage volume within 24 h after surgery, postoperative length of hospital stay, postoperative complications, visual analog scale (VAS), Neer shoulder assessment scale, ASES score, and range of motion (ROM) of the shoulder joint at 1 day, 1 week, 1 month, and 3 months after surgery in all three groups were recorded and compared.ResultsPostoperative length of hospital stay was significantly shorter in the cocktail + TXA and cocktail groups than that in the TXA group. Postoperative drainage volume was significantly higher in the cocktail group compared with TXA + cocktail group (P &lt; 0.05). At 1 day and 1 week after surgery, pain was more pronounced in the TXA group, which was significantly relieved in the cocktail and the cocktail + TXA groups (P &lt; 0.05). Pain was significantly relieved in all the three groups at 1 and 3 months after surgery. Significant functional improvement of the shoulder was achieved in all three groups at 1 week after surgery, the improvement was apparent in the cocktail + TXA groups (P &lt; 0.05), followed by the cocktail group. At 1 month after surgery, patients in the cocktail + TXA groups obtained excellent functional recovery of the shoulder joint. At 3 months after surgery, patients in all the three groups both obtained good recovery of the shoulder joint function, and the recovery was apparent in the cocktail + TXA groups (P &lt; 0.05).ConclusionArthroscopic capsular release and postoperative intra-articular infusion of cocktail combined with TXA has good safety and efficacy in the treatment of middle-age and older patients with frozen shoulder, which can reduce postoperative pain and intra-articular bleeding, promote early postoperative functional exercises and accelerate early postoperative recovery.
Substantiate a read-across hypothesis by using transcriptome data—A case study on volatile diketones
Authors: Drake Christina , Wehr Matthias M. , Zobl Walter , Koschmann Jeannette , De Lucca David , Kühne Britta A. , Hansen Tanja , Knebel Jan , Ritter Detlef , Boei Jan , Vrieling Harry , Bitsch Annette , Escher Sylvia E. 
Published: May 2023

This case study explores the applicability of transcriptome data to characterize a common mechanism of action within groups of short-chain aliphatic α-, β-, and γ-diketones. Human reference in vivo data indicate that the α-diketone diacetyl induces bronchiolitis obliterans in workers involved in the preparation of microwave popcorn. The other three α-diketones induced inflammatory responses in preclinical in vivo animal studies, whereas beta and gamma diketones in addition caused neuronal effects. We investigated early transcriptional responses in primary human bronchiolar (PBEC) cell cultures after 24 h and 72 h of air-liquid exposure. Differentially expressed genes (DEGs) were assessed based on transcriptome data generated with the EUToxRisk gene panel of Temp-O-Seq®. For each individual substance, genes were identified displaying a consistent differential expression across dose and exposure duration. The log fold change values of the DEG profiles indicate that α- and β-diketones are more active compared to γ-diketones. α-diketones in particular showed a highly concordant expression pattern, which may serve as a first indication of the shared mode of action. In order to gain a better mechanistic understanding, the resultant DEGs were submitted to a pathway analysis using ConsensusPathDB. The four α-diketones showed very similar results with regard to the number of activated and shared pathways. Overall, the number of signaling pathways decreased from α-to β-to γ-diketones. Additionally, we reconstructed networks of genes that interact with one another and are associated with different adverse outcomes such as fibrosis, inflammation or apoptosis using the TRANSPATH-database. Transcription factor enrichment and upstream analyses with the geneXplain platform revealed highly interacting gene products (called master regulators, MRs) per case study compound. The mapping of the resultant MRs on the reconstructed networks, visualized similar gene regulation with regard to fibrosis, inflammation and apoptosis. This analysis showed that transcriptome data can strengthen the similarity assessment of compounds, which is of particular importance, e.g., in read-across approaches. It is one important step towards grouping of compounds based on biological profiles.
Gender-Specific and U-Shaped Relationship Between Serum Uric Acid and All-Cause Mortality Among Chinese Older Adults: A National Population-Based Longitudinal Study
Authors: Dong Yinqiao , Wang Zhiqiang , Wang Suping , Chang Ruijie , Liu Yujie , Wang Rongxi , Chen Hui , Liu Shangbin , Qian Changlin , Cai Yong , Hu Fan 
Published: May 2023

Objectives: This study aimed to prospectively investigate gender-specific relationship between hyperuricemia and all-cause mortality among Chinese older adults.Methods: The study was based on the Chinese Longitudinal Healthy Longevity Survey (CLHLS) 2008–2018, a prospective nationwide cohort of older adults in China. Multivariate Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% CIs for all-cause mortality. Restricted cubic splines (RCS) were conducted to explore the dose-response relationship between SUA levels and all-cause mortality.Results: For older women, compared to the participants in the third quartile of SUA level, those in the highest quartile of SUA was associated with significantly higher risk of all-cause mortality in the fully adjusted model (HR: 1.41, 95% CI: 1.03–1.92). No significant associations between SUA levels and all-cause mortality were observed in older men. The present study further found a U-shaped non-linear relationship between SUA levels and all-cause mortality in both sexes of older population (P for non-linear &lt;0.05).Conclusions: This study provided prospective epidemiological evidence for the predictive role of SUA on all-cause mortality among the Chinese aging population over 10 years of follow-up, while revealing considerable gender-related differences.
A new method for investigating bioequivalence of inhaled formulations: A pilot study on salbutamol
Authors: Rezaei Homa , Khoubnasabjafari Maryam , Jouyban-Gharamaleki Vahid , Hamishehkar Hamed , Afshar Mogaddam Mohammad Reza , Rahimpour Elaheh , Mehvar Reza , Jouyban Abolghasem 
Published: May 2023

Purpose: An efficient, cost-effective and non-invasive test is required to overcome the challenges faced in the process of bioequivalence (BE) studies of various orally inhaled drug formulations. Two different types of pressurized meter dose inhalers (MDI-1 and MDI-2) were used in this study to test the practical applicability of a previously proposed hypothesis on the BE of inhaled salbutamol formulations.Methods: Salbutamol concentration profiles of the exhaled breath condensate (EBC) samples collected from volunteers receiving two inhaled formulations were compared employing BE criteria. In addition, the aerodynamic particle size distribution of the inhalers was determined by employing next generation impactor. Salbutamol concentrations in the samples were determined using liquid and gas chromatographic methods.Results: The MDI-1 inhaler induced slightly higher EBC concentrations of salbutamol when compared with MDI-2. The geometric MDI-2/MDI-1 mean ratios (confidence intervals) were 0.937 (0.721–1.22) for maximum concentration and 0.841 (0.592–1.20) for area under the EBC-time profile, indicating a lack of BE between the two formulations. In agreement with the in vivo data, the in vitro data indicated that the fine particle dose (FPD) of MDI-1 was slightly higher than that for the MDI-2 formulation. However, the FPD differences between the two formulations were not statistically significant.Conclusion: EBC data of the present work may be considered as a reliable source for assessment of the BE studies of orally inhaled drug formulations. However, more detailed investigations employing larger sample sizes and more formulations are required to provide more evidence for the proposed method of BE assay.
Alimentación de cuyes con harina de papa como sustituto del maíz amarillo y alfalfa
Authors: Tello Evangelista Lida Leny , Mendoza Tucto Raúl Filiol , Alejos Patiño Italo Wile , Cotrina Cabello Guillermo Gomer 
Published: May 2023

Perú con mayor consumo de cuyes, producción anual 16,500 toneladas de carne proveniente de 65 millones de cuyes. El objetivo fue determinar uso harina de papa de descarte como sustituto del maíz amarillo y alfalfa, en alimentación de cuyes en la localidad de Chavinillo. Metodología se empleó diseño de bloques completamente randomizados durante el periodo de nueve semanas, con 4 tratamientos, la población de estudio fueron 48 cuyes; machos y hembras. Resultado se obtuvo los datos de tratamiento testigo T0 (63,2 % de maíz molido + 10,5 % afrecho de trigo + 26,32 % de torta de soya) la mayor aceptación tuvieron cuyes machos y hembras, el índice de conversión alimenticia en cuyes machos fue 7.23 kg, tratamiento T2 (62% Harina de papa de descarte + 9 % afrecho de trigo + 29 % de torta de soya) los cuyes hembras fue 5.52 kg que obtuvo, el tratamiento T3 (64% Harina de papa de descarte + 7,7% afrecho de trigo + 28 % de torta de soya), la relación beneficio/costo tuvo en la investigación de S/ 1.70, tratamiento testigo T0 (63,2 % de maíz molido + 10,5 % afrecho de trigo + 26,32 % de torta de soya).Conclusión demostraron el tratamiento más eficaz para ganancia de peso fue el tratamiento testigo T0 (63,2 % de maíz molido + 10,5 % afrecho de trigo + 26,32 % de torta de soya), la evaluación estadística fue indiferente al uso de cualquiera dieta donde hubo inclusión de harina de papa de descarte.
Clinical Course of Adult FSGS and Minimal Change Disease in North American and Japanese Cohorts
Authors: Ozeki Takaya , Gillespie Brenda W. , Larkina Maria , Maruyama Shoichi , Alakwaa Fadhl , Kretzler Matthias , Mariani Laura H. 
Published: May 2023

Background:
Regional differences in presentation and clinical course of nephrotic syndrome (NS) have not been studied well because few studies directly compared the data from different intercontinental regions.

Methods:
We included adult nephrotic patients with Focal Segmental Glomerulosclerosis (FSGS) and Minimal Change Disease (MCD) who received immunosuppressive therapy (IST) in a North American (NEPTUNE, n=89) or Japanese (N-KDR, n=288) cohort. Baseline characteristics and rates of complete remission (CR) were compared. Factors associated with time to CR were evaluated by Cox regression models.

Results:
NEPTUNE cases had more FSGS (53.9 vs. 17.0%) and family history of kidney disease (35.2 vs. 3.2%). N-KDR cases were older (median 56 vs. 43 years) and demonstrated greater levels of UPCR (7.73 vs. 6.65) and hypoalbuminemia (1.6 vs. 2.2 mg/dL). N-KDR cases showed higher proportion of CR (overall: 89.2 vs. 62.9%; FSGS: 67.3 vs. 43.7%; MCD: 93.7 vs. 85.4%). A multivariable model showed that FSGS (vs. MCD: HR=0.28, 95%CI 0.20-0.41), systolic blood pressure (per 10 mmHg: HR=0.93, 95%CI 0.86-0.99) and eGFR (per 10 mL/min/1.73m2: HR=1.16, 95%CI 1.09-1.24) were associated with time to CR. There were significant interactions in patient age (p=0.004) and eGFR (p=0.001) between the cohorts.

Conclusion:
The North American cohort had more FSGS and more frequent family history. Japanese patients showed more severe NS with better response to IST. FSGS, hypertension and lower eGFR were shared predictors of poor treatment response. Identifying shared and unique features across geographically diverse populations may help uncover biologically relevant subgroups, improve prediction of disease course and better design future multi-national clinical trials.
Reminiscence of Education in Post-War Years: Sierra Leone as a Case Study
Authors: Jackson Emerson Abraham , Jackson Hudson Freddie 
Published: May 2023

The main purposes of this paper are as follows: (I) to provide a historical narrative of Sierra Leone's educational system, (II) to assess the impact of war on the country's educational system and pace of development in the current digital age, and finally, (III) to offer some discourses for policy dialogue in embracing the developmental landscape of the country.
Methodology. The study is based on a "narrative" approach to exploring the outcomes of the civil war that resulted in the complete disruption of the education system in Sierra Leone.
Results. The outcome of the study, which utilizes a narrative methodological approach, has captured pertinent areas of concern regarding the destructive legacy that the civil war brought to the country. Notable among these is the complete collapse of standards in the education system and, even more notably, the emergence of fake educational institutions. The results also draw attention to the positives of free education in creating equality in access to education for all.
Conclusions. The study outcome shows that Sierra Leone is making some steady progress in providing an inclusive education for that despite the bad memory that the civil war brought to the entire nation. Moving on, the study outcome noted that progress needs to be made in terms of embracing modern technology to address emerging developments in areas pertaining to Artificial Intelligence (AI) and many more. Also, to resurrect the country to its earlier glory of high educational standards, efforts must be made to raise the profile of those responsible for delivering the curriculum (teachers in particular), while at the same time ensuring high quality of graduates are made to enter through competitive salaries.
Retrospective Analysis of Morbidity and Disability Rates due to Age-related Macular Degeneration in the Republic of Uzbekistan Over a 10-year Period
Authors: Янгиева Н.Р. 
Published: May 2023

Цель. Анализ показателей заболеваемости и инвалидности вследствие возрастной макулярной дегенерации в Узбекистане за период 2010–2019 гг. Материалы и методы. Проведен ретроспективный анализ динамики показателей. Результаты. За 10-летний период общая заболеваемость возрастной макулярной дегенерацией в Узбекистане выросла в 1,8 раза и на 2019 г. составила 24,45, первичная – в 2,3 раза и на 2019 г. достигла 8,38 на 100 тыс. населения. Инвалидность вследствие возрастной макулярной дегенерации имеет тенденцию роста и на 2019 г. составила: общая – 3,44, а впервые выявленная – 0,61 на 100 тыс. населения. Заключение. Заболеваемость и инвалидность вследствие возрастной макулярной дегенерации в Узбекистане неуклонно растут, что обусловливает необходимость проведения ряда мероприятий по улучшению качества медицинского обслуживания и стандартизации мер по регистрации статистической информации.
Purpose. Analyze the incidence and disability rates due to age-related macular degeneration in Uzbekistan for the period 2010–2019. Methods. Retrospective analysis of the dynamics of indicators was carried out. Results. For the 10-year period, the overall incidence of age-related macular degeneration in Uzbekistan increased by 1.8 times and amounted to 24.45 in 2019, the primary increased by 2.3 times and in 2019 amounted to 8.38 per 100,000 population. Disability due to age-related macular degeneration tends to increase and in 2019 the total was 3.44, and for the first time 0.61 per 100,000 population. Conclusion. The incidence and disability due to age-related macular degeneration in Uzbekistan is steadily increasing, which necessitates a number of measures to improve the quality of medical care and standardize measures for registering statistical information.
Hubungan Alat Bantu Napas Noninvasive dengan Hemodinamik pada Pasien Covid-19 di RSAI Kota Bandung
Authors: Hidayat Yayat , Kosasih Cecep Eli , Mulyati Titin 
Published: May 2023

Masalah yang dihadapi pada pasien Covid-19 yaitu adanya gagal napas yang memerlukan oksigen dengan aliran atau konsentrasi yang tinggi. Terapi oksigen dengan aliran yang tinggi diberikan menggunakan <em>High Flow Nasal Cannula</em> ataupun menggunakan <em>Noninvasive Ventilation</em>. Penelitian ini bertujuan untuk mengetahui hubungan alat bantu napas <em>noninvasive </em>dengan hemodinamik pada pasien Covid-19 di RSAI Kota Bandung. Penelitian berupa studi korelasi dengan pendekatan <em>cross sectional</em>. Sampel berjumlah 254 orang pasien Covid-19. Pengambilan data berupa data rekam medis. Hasil penelitian menunjukan bahwa terdapat hubungan alat bantu napas dengan frekuensi napas dengan p-value 0,002 (p &lt; 0,05) OR 2,348. Terdapat hubungan alat bantu napas dengan saturasi oksigen dengan p-value 0,018 (p &lt; 0,05) OR 1,901. Terdapat hubungan alat bantu napas dengan tekanan darah sistol dengan p-value 0,036 (p &lt; 0,05) OR 1,793. Terdapat hubungan alat bantu napas dengan tekanan darah diastol dengan p-value 0,000 (p &lt; 0,05) OR 3,053. Terdapat hubungan alat bantu napas dengan <em>heart rate</em> dengan p-value 0,002 (p &lt; 0,05) OR 2,192. Simpulan dari penelitian ini terdapat hubungan alat bantu napas noninvasive dengan hemodinamik. Didapatkan respon pasien Covid-19 terhadap hemodinamik lebih baik menggunakan HFNC dibandingkan NIV sebagai alat bantu napas noninvasive. Penggunaan HFNC layak dipertimbangkan untuk memperbaiki hemodinamik pasien Covid-19.
Communities in Streaming Graphs: Small Space Data Structure, Benchmark Data Generation, and Linear Algorithm
Authors: Gupta Shubham , Kundu Suman 
Published: May 2023

<p>Identifying and preserving community structures in a streaming graph is a very challenging task. However, many applications require the identification of these communities in very limited space and time. In this paper, we design Community Sketch, a small space data structure that efficiently preserves communities. On query, it provides communities in constant time. With the use of community sketch data structure, a linear streaming community detection algorithm is proposed. Experimental results on the large real-world networks show that our algorithm outperforms other state-of-the-art algorithms in terms of quality metrics (NMI, F1-score, and WCC). Further, we propose an algorithm to produce benchmark network, namely, Temporal Community Benchmark Dataset (TCBD) which contains both true community labels and temporal information of edges. These synthetic networks are used to validate the proposed algorithm<br>
</p>
Effectiveness of Nursing Counseling on Reliefs Psychological Burdens upon women after Mastectomy
Authors: Abbas Iqbal M. , Ghazal Rusul S. 
Published: May 2023

Objective: To identify the effectiveness of nursing counseling on psychological burdens on women after mastectomy.
Methodology: A quasi-experimental design (one group pretest-posttest design) was conducted on non-probability (purposive) sample of thirty women who had received a mastectomy as an intervention group selected during period in 2nd August to 10th November 2011. The study was conducted at three hospitals in Baghdad city which considered the main settings to providing health care for the patients with all types of cancer. Baseline data collection (pre test), post-test 1and post-test 2 and application of the nursing counseling on psychological burdens after mastectomy. The questionnaire form is consisted of two parts which included demographic and reproductive characteristics and psychological burdens after mastectomy. Content validity and reliability of the questionnaire determined through a pilot study, descriptive and inferential statistic is used to analyze the data. The psychological burdens measured by the scale developed by the researcher according to the literature review.
Results: Results of the study showed that the highest of study sample 36.7 % were in age group (50-60) years old, the highest mean of score related to the psychological burdens were refer to the focus and attention, depression, negative feels, anxiety, thinking, and finally followed by positive feels, was found significant differences between pre and post test related to psychological burdens at standard error P ≤ 0.01.
Recommendation: The study recommends establishing the counseling center in the breast cancer clinics to providing the psychological support and advices for women. The counseling program should be based in treatment program to reduce the burdens and symptoms of cancer and improving the quality of life.
Formulation and Physical Test of Gel Mask Combination Ethanol Extract Gotu Kola (Centella asiatica (L.) Urb.) and Niacinamide with Carbomer Variations
Authors: Juliadi Debby , Juanita Rr Asih 
Published: May 2023

Pegagan (Centella asiatica (L.) Urb.) merupakan tanaman yang dapat dimanfaatkan sebagai kosmetika. Herba pegagan mengandung senyawa triterpenoid saponin salah satunya asiatikosida yang berkhasiat sebagai antioksidan yang dapat membantu pertumbuhan kolagen pada kulit dengan maksud mengurangi keriput dan menghilangkan bintik hitam pada wajah. Niasinamida adalah vitamin B3 yang dapat memberikan efek pencerah dan pelembab pada kulit. Masker gel merupakan salah satu kosmetika dengan bentuk sediaan setengah padat yang aman digunakan pada kulit yang berjerawat, selain itu masker gel mudah merata apabila dioleskan pada kulit, memberikan sensasi menyejukkan, dan tidak menimbulkan bekas di kulit. Penelitian ini bertujuan untuk mendapatkan formula masker gel kombinasi ekstrak etanol herba pegagan dan niasinamida yang memiliki mutu fisik yang baik dan untuk mengetahui stabilitas selama penyimpanan. Penelitian ini bersifat eksperimental yang dilakukan di laboratorium dan bertujuan sebagai pengembangan yaitu dibuat sediaan masker gel dan diuji mutu fisik dari sediaan tersebut. Pengujian yang dilakukan meliputi organoleptis, homogenitas, pH, daya sebar, dan uji sineresis yang kemudian dianalisis dengan cara deskriptif. Proses pembuatan ekstrak kental herba pegagan dilakukan dengan metode maserasi. Masker gel dibuat dengan kombinasi ekstrak kental herba pegagan dan niasinamida dengan variasi karbomer 1%, 1,5%, dan 2% kemudian diuji mutu fisiknya selama 4 minggu. Hasil penelitian ini menunjukkan bahwa sediaan masker gel kombinasi ekstrak etanol herba pegagan dan niasinamida dengan variasi karbomer 1% (formula 1) dan 1,5% (formula 2) menghasilkan mutu fisik yang baik dilihat dari pengujian organoleptis, homogenitas, pH, daya sebar, dan uji sineresis, serta formula 1 dan 2 tersebut stabil selama penyimpanan 4 minggu.