bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxia-mediated chemotaxis and residence of macrophage in decidua by secreting VEGFA and CCL2 during normal pregnancy
Authors: Qin Xue-Yun , Shen Hui-Hui , Zhang Xin-Yan , Zhang Xing , Xie Feng , Wang Wen-Jun , Xiong Yu , Mei Jie , Li Ming-Qing 
Published: February 2023

In brief
Hypoxia is vital for the establishment of the maternal–fetal interface during early pregnancy. This study shows that decidual macrophages (dMφ) could be recruited and reside in decidua under the regulation of hypoxia/VEGFA-CCL2 axis.

Abstract
Infiltration and residence of decidual macrophages (dMφ) are of great significance to pregnancy maintenance for their role in angiogenesis, placental development, and inducing immune tolerance. Besides, hypoxia has now been acknowledged as an important biological event at maternal–fetal interface in the first trimester. However, whether and how hypoxia regulates biofunctions of dMφ remain elusive. Herein, we observed increased expression of C–C motif chemokine ligand 2 (CCL2) and residence of macrophages in decidua compared to secretory-phase endometrium. Moreover, hypoxia treatment on stromal cells improved the migration and adhesion of dMφ. Mechanistically, these effects might be mediated by upregulated CCL2 and adhesion molecules (especially ICAM2 and ICAM5) on stromal cells in the presence of endogenous vascular endothelial growth factor-A (VEGFA) in hypoxia. These findings were also verified by recombinant VEGFA and indirect coculture, indicating that the interaction between stromal cells and dMφ in hypoxia condition may facilitate dMφ recruitment and residence. In conclusion, VEGFA derived from a hypoxic environment may manipulate CCL2/CCR2 and adhesion molecules to enhance the interactions between dMφ and stromal cells and thus contribute to the enrichment of macrophages in decidua early during normal pregnancy.
Mechanical processing of hydroxyapatite through sintering and multi-objective optimization technique for biomedical application
Authors: Abifarin Fredah Batale , Musa Zahraddeen , Abifarin Johnson Kehinde 
Published: February 2023

AbstractHydroxyapatite (HAp) has been widely applied in the area of tissue engineering, however, its poor mechanical properties limit it in load bearing biomedical application. To improve the mechanical integrity of HAp, this study reports the synthesis, optimization and the significance of processing parameters on the physic-mechanical properties of HAp. The HAp was produced from biogenic source through at 900 °C. The L9 Taguchi orthogonal array was employed, considering two processing parameters namely, HAp particle size (100, 300, and 600 $$\mathrm{\mu m}$$

μ
m

) and compaction load (3, 6, and 9 KN). The raw bones (RB) and the synthesized HAp were characterized for phase structure and functional groups analysis. The analysis showed the characteristics of a typical calcium phosphate material. The multiple response optimization revealed that 600 $$\mathrm{\mu m}$$

μ
m

particle size 6 KN compaction load are the optimal processing parameters in the manufacturing of high biomedical performance HAp.

Graphical Abstract
The Impact of the COVID-19 Pandemic on Pregnant Women: A Qualitative Approach
Authors: Uludağ Elif , Türkcü Sinem Göral , Serçekuş Pınar , Özkan Sevgi 
Published: February 2023

BACKGROUND: Pregnant women are one of the special groups most affected by the COVID-19 pandemic. The aim of this study was to analyze how the COVID-19 pandemic influenced the feelings, thoughts, and behaviors of pregnant women.METHOD: A descriptive phenomenological approach was employed to explore the experiences of 15 pregnant women. Data were gathered by using semi-structured interviews focusing on pregnant women’s feelings, thoughts and behaviors. Word cloud analysis and content analysis were performed.FINDINGS: Data analysis revealed three main themes: emotions, hardships, and coping. Emotions were grouped into five categories: fear, anxiety, disappointment, loneliness, and regret. Hardships were grouped into two categories: physical and financial. Coping was grouped into four categories: social support, normalization, religious practices, and positive thinking. According to word cloud analysis, the most frequently mentioned words were pregnant, COVID-19, anxiety, fear, positive thinking, hardships, regret, stress, affect, and alone.CONCLUSIONS: Women experienced feelings of fear, anxiety, disappointment, loneliness, and regret in the prenatal period. They also faced physical and financial hardships and benefited from social support, normalization, religious practices, and positive thinking to cope with these hardships.
Community Perspectives on Home Birth in Saudi Arabia
Authors: Altaweli Roa , Zedan Haya S. , Shaban Insaf 
Published: February 2023

BACKGROUND: The World Health Organization released a statement indicating that women can choose to give birth at home if their pregnancy is low risk and they receive the appropriate level of care during labor and childbirth. Additionally, there needs to be a contingency plan for transfer to a properly staffed and equipped birthing unit in case of problems. The Saudi Arabian Ministry of Health “Safe Birth Model of Care” by 2030 aims to have a midwifery-led continuity of maternity care as standard: low-risk births are to take place at home or at a birth center, depending on the preference of the woman and her family. Low-risk pregnant women will be expected to receive antenatal care from an appropriately trained and experienced primary care physician or midwife, as appropriate, with the option to refer to the comprehensive obstetrics service as necessary. This midwifery-led continuity of care has yet to be implemented in Saudi Arabia (Altaweli et al., 2020).RESEARCH PURPOSES: The purposes of this study were to assess the community of respondents to an online survey and perspectives regarding home birth and determine challenges to initiation of a policy and practice of home birth in Saudi Arabia.METHODS: A cross-sectional design using an online 14-item online survey instrument was used to collect data from 5,930 respondents who provided their views on home birth in Saudi Arabia.FINDINGS: A total of 53.4% of respondents were interested in the concept of home birth, with the COVID-19 pandemic as the reason for this interest in slightly more than one-third of respondents (37.4%). Additionally, 14.3% hoped to avoid unnecessary medical interventions in a hospital setting. It was also found that 46.6% of the respondents were not interested in the potential for a home birth, and of those, 98.8% attributed their disinterest in the safety of hospitals to their preference of a home birth.CONCLUSIONS: There was significant interest in the concept of home birth in Saudi Arabia due to the COVID-19 pandemic and related restrictions. This interest was related to a desire of women to have a more positive birth experience and avoid unnecessary medical interventions. The findings suggest a clear need for a fully developed home birth policy, fully integrated with existing maternity care services in Saudi Arabia, and increased awareness of the safety and suitability of home birth for low-risk women. Home birth should be an option for women with low-risk pregnancies in Saudi Arabia.
Immune Dysregulation in Acute SARS-CoV-2 Infection
Authors: Grimm Lauren , Onyeukwu Chinyere , Kenny Grace , Parent Danielle , Fu Jia , Dhingra Shaurya , Yang Emily , Moy James , Utz PJ , Tracy Russell , Landay Alan 
Published: February 2023

Introduction: Neutralizing antibodies have been shown to develop rapidly following SARS-CoV-2 infection, specifically against spike (S) protein, where cytokine release and production is understood to drive the humoral immune response during acute infection. Thus, we evaluated the quantity and function of antibodies across disease severities and analyzed the associated inflammatory and coagulation pathways to identify acute markers that correlate with antibody response following infection. Methods: Blood samples were collected from patients at time of diagnostic SARS-CoV-2 PCR testing between March 2020-November 2020. Plasma samples were analyzed using the MesoScale Discovery (MSD) Platform using the COVID-19 Serology Kit and U-Plex 8 analyte multiplex plate to measure anti-alpha and beta coronavirus antibody concentration and ACE2 blocking function, as well as plasma cytokines. Results: A total of 230 (181 unique patients) samples were analyzed across the 5 COVID-19 disease severities. We found that antibody quantity directly correlated with functional ability to block virus binding to membrane-bound ACE2, where a lower SARS-CoV-2 anti-spike/anti-RBD response corresponded with a lower antibody blocking potential compared to higher antibody response (anti-S1 r = 0.884, P < 0.001; anti-RBD r = 0.75, P < 0.001). Across all the soluble proinflammatory markers we examined, ICAM, IL-1β, IL-4, IL-6, TNFα, and Syndecan showed a statistically significant positive correlation between cytokine or epithelial marker and antibody quantity regardless of COVID-19 disease severity. Analysis of autoantibodies against type 1 interferon was not shown to be statistically significant between disease severity groups. Conclusion: Previous studies have shown that proinflammatory markers, including IL-6, IL-8, IL-1β, and TNFα, are significant predictors of COVID-19 disease severity, regardless of demographics or comorbidities. Our study demonstrated that not only are these proinflammatory markers, as well as IL-4, ICAM, and Syndecan, correlative of disease severity, they are also correlative of antibody quantity and quality following SARS-CoV-2 exposure.
Microbiome in soils of Mendoza: microbial resources for the development of agroecological management in viticulture
Authors: Paolinelli Marcos , Martinez Laura Elizabeth , García-Lampasona Sandra , Diaz-Quirós Camilo , Belmonte Marcelo , Ahumada Gastón , Pirrone Miguel Ángel , Farber Marisa Diana , Escoriaza Georgina , Longone Valeria , González Magalí , Lerena Cecilia , Combina Mariana , Mercado Laura Analía 
Published: February 2023

Rhizosphere microorganisms are considered an extension of plants, representing critical actors involved in the promotion of plant nutrient intake from the surrounding environment. Consequently, a great focus is being made on soil microorganisms since they are considered a promising source for crop resilience improvements under a global climate change scenario. To explore bacterial and fungal communities from arid soils in vineyards and their surroundings from two regions with very different climate and tillage histories, an amplicon sequencing analysis was performed. Specifically, Santa Rosa (SR) is in a region commonly known as the first zone, characterised by low altitude (607 m.a.s.l., Winkler V), while Gualtallary (G) is in the Uco Valley Zone, a region with high altitude (1245 m.a.s.l., Winkler III); both in the productive wine region of Mendoza. SR is characterised by its long cultivation history, while G is a recently cultivated region. Topsoil samples were collected and used for bacterial and fungal community profile characterisation. Ascomycota was the predominant phylum (38–97 %) in mycobiome composition, whereas Proteobacteria was the most abundant bacterial phylum (26–34 %) in both regions. Moreover, the main factor explaining microbiome differences between regions was the carbon-to-nitrogen ratio. Anaerolineae and Gammaproteobacteria were a distinctive bacterial class in SR-cultivated soils. Azospirillales were highly abundant in SR uncultivated soils, while Rhizobiales were differentially abundant in G uncultivated soils. Regarding functional analysis, soils from SR showed a higher denitrification activity of nitrifiers as well as glucose-related metabolism, while in G soils, bacterial photosynthesis activities were a differential trait. In addition, Actinobacteria abundance was lower in SR-cultivated soils, indicating a higher susceptibility of this phylum to grapevine crop practices. These results allow the development of hypothetical models of the local microbial resources and their contribution to grapevine nutrition, which is highly important to elaborate recommendations for grapevine management to preserve soil health in vine areas of Mendoza.
Pendidikan Sufistik Bagi Masyarakat Kelas Menengah Muslim (Konstruksi Identitas Keberagamaan Berbasis Tarekat)
Authors: Ulya Inayatul , Nurhadi Agus 
Published: February 2023

<span lang="IN">Sufistic education and the rise of the tarekat community in Muslim middle class groups is a phenomenon that shows the rise of religion in the public sphere. The religious expression displayed by the Muslim middle class is a form of religious accommodation to current life which turns out to be able to work harmoniously. Even religion can be a solution to life on the problems experienced by modern society. This article explains that the sufistic education that was followed by the Muslim middle class became a medium to construct their religiousity. They make the tarekat an identity that distinguishes them from other Muslim communities. Sufistic education that is followed by Muslim middle class can be seen in two dimensions, <em>First</em>, the individual dimension that emphasizes the efforts of Muslim middle class to carry out the practice of the tarekat in order to build piety, improve themselves, build better character, uphold the values moral and religious values </span><span lang="IN">in daily life. <em>Second</em>, the social dimension is about the needs of the Muslim middle class to join in the tarekat community in order to build a collective identity that functions strategically in a better social life</span>
Fluxes and Composition of Particulate Matter in the Water Column of South Baikal (between March 2015 and March 2016)
Authors: Vologina E.G. , Sturm M. , Vorob’eva S.S. 
Published: February 2023

Abstract
—The paper provides the results of experiments with sediment traps in the deep-water part of the South Basin of Lake Baikal (depth of 1366 m), installed from March 2015 to March 2016 in order to study recent sedimentation within the lake. We present new data on total fluxes of particulate matter and fluxes of biogenic components (SiO2biog, Сorg, and Ntot) at different depths of the water column both for the whole year and for individual periods of the year. Diatom analyses were carried out for all obtained samples. The total flux of sedimentary material averaged 94.9 g/m2/y; the average fluxes of SiO2biog, Сorg, and Ntot were 23.9, 11.6, and 0.94 g/m2/y, respectively. The molar C/N ratio varies from 11 to 21 and indicates a predominance of allochthonous material in almost all samples. Maximum fluxes of sedimentary matter were recorded from 20 June to 20 July 2015. This period corresponds to the bloom of diatoms of the species Synedra acus. This species amounts to &gt;94% of the total diatom content in all samples taken during this year. The recent predominance of Synedra acus in the water column, as well as in the surface bottom sediments of South Baikal, is probably due to the climate warming.
Boosting Reaction Rate of Acids for Better Acid Fracturing Stimulation of Dolomite-Rich Formations
Authors: Sayed Mohammed A. , Cairns Amy J. , Chang Fakuen F. 
Published: February 2023

Summary
Carbonate reservoirs can be stimulated by injecting acids to boost the rate of hydrocarbon production from low-permeability zones via the creation of conductive pathways. The reaction rate between the acidizing fluid and rock matrix is a key parameter in determining the success of stimulation treatments. Dolomite-rich formations are known to exhibit slower reaction kinetics as compared to calcite. As a result, some acid fracturing treatments fall short of creating an extended fracture or the desirable etching pattern on the fracture faces, thus limiting hydrocarbon flow. Accordingly, the development of an acid package to boost the dolomite dissolution rate will be advantageous to the efficiency of the stimulation treatment in dolomite-rich reservoirs.
Accelerating the reaction rate of dolomite with strong mineral acid (i.e., hydrochloric acid, HCl) can be achieved through an additive-driven chemical approach based on the addition of judiciously selected sulfonate-based surfactants. To pinpoint the optimal surfactant(s) type and concentration, static dissolution testing was performed under ambient conditions using outcrop dolomite core samples (Silurian and Guelph). Each core sample was reacted with 28 wt% HCl in the presence and absence of sulfonate-based surfactant additives for a predetermined time. Selected surfactants are used in comprehensive reaction kinetics studies at reservoir conditions using a rotating disk apparatus (RDA).
Based on the results of the ambient screening tests, three formulations were found to accelerate the reaction rate by up to 30% as compared to using 28 wt% HCl without the additive(s). The kinetics data collected at a pressure of 3,000 psi and temperatures of 175 up to 300°F showed that the reaction rate of Guelph dolomite can be accelerated by as much as 17–55% with one of the formulations. Coreflood experiments showed an increase in the acid PV to breakthrough (PVBT) when the surfactant package was added to the acid formulation pointing to a rise in the reaction rate of dolomite and the developed acid formulations. The acid formulations showed an improvement in the dolomite and acid reaction rate, which creates the opportunity to apply these formulations in the field to improve the outcome of acid fracturing treatments in dolomite-rich reservoirs.
Adherence enhancing interventions for pharmacological and oxygen therapy in patients with COPD: protocol for a systematic review and component network meta-analyses
Authors: Ammous Omar , Andreas Stefan , Friede Tim , Kampo Regina , Schwarz Sarah , Wollsching-Strobel Maximilian , Salem Susanna , Windisch Wolfram , Mathes Tim 
Published: February 2023

Abstract
Background: Chronic Obstructive Pulmonary Disease (COPD) is characterised by hyperinflation and expiratory airflow limitation due to long-term exposure to irritants. The variety and complexity of COPD treatment and the possible added comorbidities may make the patients find it difficult to cope with the required medications. That’s why supporting patients' adherence is critical because not taking medications correctly increases the risk of complications and creates an additional financial burden. A range of interventions aiming to improve patient adherence were used, and most of them are complex since they involve a mix of elements. Furthermore, despite the variety of available tools, assessing adherence is challenging because clinicians usually don’t get a concrete judgement if their patients followed their treatment plan reliably.
Methods: We aim to evaluate the effectiveness of adherence-enhancing interventions for COPD patients, explore which intervention (component) works for which patients and check the factors influencing the implementation and participant responses. We will include all studies investigating the effect of adherence-enhancing intervention on patients with COPD. We plan to perform two patient interviews (one before and one after the systematic review) and follow a sequential approach to integrating qualitative and quantitative information. The first interview aims to understand patients’ needs and prioritise the selection of the outcomes. The second interview will be conducted after the evidence synthesis to present the results to patients. Two reviewers with complementary expertise will perform the screening, data extraction and risk of bias assessment. We will perform two meta-analyses: the first will be pair-wise random-effects meta-analyses to combine homogeneous studies. Secondly, we will perform random-effects component network meta-analyses to identify the most effective components and combinations of components. To determine the degree of complexity, we will use the iCAT_SR checklist, and then, following a logical model, we will group the interventions according to prespecified criteria.
Discussion: This systematic review aims to point out the most effective and implementable adherence-enhancing interventions by using methods for synthesising evidence on complex interventions and involving COPD patients all along with the review process.
Systematic review registration: PROSPERO CRD42022353977
The diagnostic performance of 18F-FDG PET/CT versus 18F-NaF PET/CT in breast cancer with bone metastases: an indirect comparative meta-analysis
Authors: Hu Hongyu , Hu Xianwen , Liang Zhigang , Yang Wenbi , Li Song , Li Dandan , Cai Jiong 
Published: February 2023

Abstract
Purpose: This study aimed to evaluate the comparison of the diagnostic performance of 18F-FDG PET/CT and 18F-NaF PET/CT in breast cancer patients with bone metastases.
Materials and Methods: The databases PubMed and Embase were used to search the English literature on the diagnostic performance of 18F-FDG PET/CT and 18F-NaF PET/CT for breast cancer bone metastases. Two authors independently extracted data. Studies were selected for analysis if the data presented in the study reports could be used to construct a 2×2 contingency table. The methodology quality of the enrolled studies was assessed by QUADAS-2, and forest plots were generated based on the sensitivity and specificity of 18F-FDG PET/CT versus 18F-NaF PET/CT in the diagnosis of breast cancer bone metastases. Stata Software Version 14.0 (Stata Corporation, College Station, TX, USA) was used for statistical processing.
Results: A total of 14 articles were identified, eight of which were about the analysis of 18F-FDG PET/CT in the diagnosis of breast cancer bone metastases, five of which were about 18F-NaF PET/CT, and one article was an analysis of the diagnostic performance of both them. The studies of 18F-FDG PET/CT and 18F-NaF PET/CT included 530 and 389 patients, respectively. The pooled sensitivities were 0.88 (95% CI: 0.80-0.99) for 18F-FDG PET/CT and 0.98 (95% CI: 0.92-1.00) for 18F-NaF PET/CT, respectively, and the pooled specificities were 0.99 (95% CI: 0.98-1.00) and 0.91 (95% CI: 0.76-0.97), respectively. The area under the SROC curve of both 18F-FDG PET/CT and 18F-NaF PET/CT were 0.99 (95%CI: 0.98-1.00),, of which 18F-FDG PET/CT 1038 lesions were included and a sensitivity of 0.84 (95% CI: 0.67-1.00) and specificity of 1.00 (95% CI: 0.98-1.00) were reported for lesion-based 18F-FDG PET/CT for BM. Compared with 18F-FDG PET/CT, 18F-NaF PET/CT showed higher sensitivity (98% vs 88%, p= 0.09), but lower specificity (91% vs 99%, p=0.13), both of which were not statistically significant.
Conclusions: The results showed that 18F-NaF PET/CT and 18F-FDG PET/CT are accurate methods for detecting bone metastases in breast cancer patients. The diagnostic accuracy of both is the same.
Synergetic degradation of carbamazepine using hybrid advanced oxidation processes of hydrodynamic cavitation/ UV/ ZnO/ZnFe2O4 for persulfate activation
Authors: Roy Kuldeep , Moholkar Vijayanand Suryakant 
Published: February 2023

Abstract
Note: Please see pdf for full abstract with equations.
This study investigated the in-situ chemical oxidation of the pharmaceutical compound carbamazepine (CBZ) using the combination of hydrodynamic cavitation (HC) and persulfate anion (S2O82-) and simultaneous activation of S2O82- anion by HC, UV–C irradiation and ZnO/ZnFe2O4 particles. Results show that the HC-based UV/persulfate / ZnO/ZnFe2O4 process effectively achieved 98.13 ± 1.03 % CBZ degradation. In binary oxidation system, viz. HC+UV, HC+S2O82-, HC+ZnO/ZnFe2O4, and UV+ZnO/ZnFe2O4, significantly higher 65.73% degradation was obtained using HC+S2O82- system. CBZ degradation profiles were analyzed using a mathematical kinetic model based on the reaction network. Experimental and simulated degradation profiles were matched with the initial [Fe2+]/[H2O2] ratio as a manipulation parameter. The closest match between experimental and simulated CBZ degradation profiles was obtained for the initial [Fe2+]/[H2O2] ratio = 10, which indicated enhanced leaching from the surface of ZnO/ZnFe2O4 particles. The results demonstrated that HC based persulfate oxidation system might prevent emergent pollutants like carbamazepine from polluting water.