bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trace Elemental and Heavy Metal levels in frequently consumed local Vegetables of three Chronic Kidney Disease prevalent Villages
Authors: Murthy G. Narayana , Yadav P. Balarama Swamy , Yadav P Balarama Swamy 
Published: March 2023

Abstract
The present study reports the Trace Elemental and Heavy Metal (24 Elements) levels in six (Capsicum frutescence L., Carica papaya L., Momordica charantia L., Moringa oliefera Lam., Musa Sapientum L., and Solanum melongena L.) Local and frequently consumed vegetables from three locations which are severely affected Villages by Chronic Kidney Disease (CKD) in Kaviti Mandal, in Uddanam area of Srikakulam district. The samples are collected from these three Villages and are subjected to ICP-MS analysis. To test a group of 24 Elements viz., Li, Be, Al, Sc, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, As, Se, Rb, Sr, Ag, Cd, Cs, Ba, TI, Rb, and U for their levels, the obtained levels of each Element is compared with the WHO/FAO permissible values. In these 24 Elements, as per FAO/WHO standards 16 Elements shows severe affect on kidneys and the remaining 8 (Mn, Co, Ni, Cu, Zn, Se, Sr, and TI) cause other health problems when they are in high concentration[1-5]. The results reveal that Ba is in high concentration (2.51 times) in all the tested samples and Pb is in high concentration (1.28 times) in 11 samples, Ag and Fe are in one sample each. Among the three locations highest Ba concentration is observed in S1 (Capsicum) of L2 followed by S5 (Musa) and S1 (Capsicum) of L1. The highest Pb concentration is present in S1 (Capsicum) of L3 followed by S1 (Capsicum) of L2. The results reveal that out of the six vegetables tested, Capsicum showed high concentrations of Ba and Pb. The non-uniformity of levels of Trace Elements and Heavy Metals with regard to location and samples may be due to soil and ground water.
Overlying strata movement and stress evolution under multiple coal seam mining: insights from physical modelling
Authors: YANG Yi , LI Yingchun , WANG Lujun , WU Yang 
Published: March 2023

Abstract
Extensive studies have been conducted on the movement of overlying strata when a single coal seam is mined. However, structural characteristics and associated stress field variation of the overlying strata over multiple coal seam mining remain unclear. Here we performed physical modelling experiments analogous to No.42108 working face of Buertai coal mine, Shendong coalfield, where No.22 coal seam (2.9m thickness) was mined first, preceding No.42 upper coal seam (6.1m thickness) with an inter-coal-seam distance of 72.8m. We employed DIC (digital image correlation) measurement and systematically-laid pressure cells to visualize the overlying strata movement and monitor stress field variations over multiple coal seam mining. We found that the stress of the inter-coal-seam strata increased significantly in the late mining stage of No.22 coal seam due to the strata collapse, and culminated after compaction of the caved blocks. The inter-coal-seam strata stress gradually decreased over mining of No.42 upper coal seam and arrived at zero after the inter-coal-seam strata collapsed. The mining of No.42 upper coal seam aggravated the roof settlement of No.22 coal seam; and the floor stress was noticeably lower than that of No.22 coal seam due to the pressure-relief caused by the former mining activity. Our physical modelling findings advanced our understanding on structural characteristics and stress evolutions of overlying strata over multiple coal seam mining and offered guidance for prediction and mitigation of strata movement associated disasters in underground coal mining with geomechanical and mining conditions similar to those of Buertai coal mine.
Comparison of salivary cortisol levels between women with functional hypothalamic amenorrhea and healthy women: A pilot study
Authors: Koukoubanis Konstantinos , Stefanaki Katerina , Karagiannakis Dimitrios S , Kalampalikis Andreas , Michala Lina 
Published: March 2023

Abstract
Introduction

Functional Hypothalamic Amenorrhea (FHA) has been associated with excessive-chronic stress, eating disorders and weight loss. A common feature is the increased serum cortisol, but its measurement has many limitations. Currently, salivary cortisol (SC) has been proposed as a more sensitive and adequate index.

Aim

To investigate the SC alterations through a 24-hour period and the possible correlation with the severity of stress in women with FHA.

Methods

Between July 2019 and March 2021, 12 FHA women and 12 healthy controls of comparable age were included. Psychological, eating and physical abnormalities were evaluated by applying equivalent validated self-questionnaires.

Results

No significant differences were found between FHA women and healthy individuals with respect to morning (8:00 am) serum cortisol and ACTH (522.5±155.3 vs 443.1±138.4; p=0.23 and 37±47.7 vs 17.4±10.2;p=0.18 respectively). Women with FHA had statistically significant higher morning SC compared to control subjects (21.81±5.63 nmol/l vs 12.76±3.64 nmol/l;p<0.0001), while no significant differences were found regarding the afternoon (4:00 pm) and midnight (12:00 am) SC. A significant positive correlation was found between morning SC and morning serum cortisol (r=0.532,p=0.007), as well as with EAT-26 (r=0.527,p=0.008) and HADS-Anxiety score (r=0.471,p=0.02). Additionally, a significant negative correlation between morning SC and BMI was observed (r=-0.53, p=0.009).

Conclusion

Compared to serum cortisol, SC seems to express better the hypercortisolemic state of women with FHA and correlates well with the underlying contributing factors. Larger studies are needed in order to confirm these results and validate the optimal SC cut-off value associated with the development of FHA.
Application of Failure Mode Effect Analysis (FMEA) in the traditional medicine Industry: A Case study on Spirulina Capsule Production
Authors: Rustandi Tedi , Andri Devid , Hayati Fakhriah 
Published: March 2023

Abstract
Spirulina powder is used as a raw material by many traditional medicine industries in Indonesia. Spirulina powder produced in capsule preparations generally has indications for maintaining the immune system. Risk control through quality risk management has been required by the BPOM of the Republic of Indonesia as a consumer security guarantee. The method used to control risk is FMEA combined with fishbone analysis. This research produces several potential risks in the process stages until Spirulina powder is finished. Processes that potentially pose a risk and need to be controlled include receiving raw materials, storing raw materials, mixing, filling, and finishing good storage. The recommended controls to reduce risk are environmental control, machine, equipment, in-process control, and verification of the raw materials' correctness
Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats
Authors: Kahwa Ivan 
Published: March 2023

Abstract
Background
Species in genus Vernonia (Asteraceae) are traditionally used in the management of
different ailments for instance the leaves in both fresh and dry forms have been used in
dressing wounds. Anecdotal reports show that ash of Vernonia amygdalina (V.
amygdalina) has been utilised in the treatment of wounds, however there are no
scientific reports to substantiate this claim. Thus, the present study focused on
comparing the wound-healing activity of its leaf and leaf ash extracts.
Methods
In this study, the wound healing activity of V. amygdalina leaf was carried out in Wistar
Albino rats in an excision wound model using its aqueous extract (AE), and leaf ash
(LA) at concentrations of 1%, 2% and 3% (w/v). Mupirocin ointment and distilled water
were used as positive and negative controls respectively. The wound diameter was
measured every 3 days from day 1 to day 22 and the results were used to calculate the
percentage of wound reduction in all groups.
Results
Significant wound healing activity was observed in all groups except 3% (w/v) AE,
against the negative control group (p<0.05). Group 2 (1% AE), group 5 (1% LA), and
group 6 (2% LA) showed faster wound healing than the positive control (p<0.05). Leaf
ash was shown to have the best wound healing activity, and its lower concentrations
worked better than the category of the same concentrations in aqueous extracts.
Conclusions
Our findings have for the first time confirmed the traditional claim of using V.
amygdalina ash in the treatment of topical wounds.
Inequality of opportunities and beliefs about economic outcomes in the Western Balkans
Authors: Drishti Elvisa , Mehmetaj Nevila , Imami Drini , Zhllima Edvin 
Published: March 2023

Abstract
An egalitarian society is one that incentivises individuals to use their resources in order to be improve their economic outcomes and achieve social integration. The objective of this paper is to analyse Inequality of Opportunity (IOp), a measure of deprivation which counts for differences in economic outcomes, as well as estimate its effects. The research findings show that IOp is positively associated with statements on beliefs about the unfair distribution of outcomes in the sense of a successful life and towards the most important factors of finding a job at present. On the other hand, higher levels institutional trust reverse the effect of IOp. There are additional positive impacts in terms of such beliefs for those whose access to primary goods is limited due to disfavourable initial conditions at birth (being born in a rural area and being a female),who perceive themselves as belonging to a lower social class and those who have had positive experiences from their interaction with institutions. Findings are especially important in the context of countries with weak institutions and democracy, such as the case of Western Balkans (focus of this paper) and urge for a strengthening of institutions which regulate and support the citizens’ integration into society.
Interpolation numerical calculus for analytic functions by using algebraic polynomials
Authors: Fukuchi Tsugio 
Published: March 2023

Abstract

The finite difference method is a powerful method for numerical analysis of equilibrium and steady states of physical phenomena. In the traditional finite difference method, second-order accuracy differences have been used. From an engineering point of view, this approach is often regarded as having sufficient accuracy. However, much research has been done on increasing the accuracy of this numerical analysis. Virtual error zero (VE0)calculations are defined as calculations that can perform numerical calculations with exact solutions for 15 significant digits under double-precision calculations. VE0 calculation is considered to be the ultimate goal of high-accuracy numerical analysis. This paper is written from the viewpoint that such numerical calculations have inherent value. VE0 calculations are always obtained as long as we deal with functions having no singularities in the computational domain for ordinary differential equations as boundary value problems. Furthermore, VE0 calculation is possible even for ordinary differential equations as initial value problems. In both numerical analyses, algebraic polynomials commonly play an important role. This paper comprehensively examines the important role that algebraic polynomials play in increasing the accuracy of numerical calculations in various fields of numerical analysis, such as numerical differentiation, numerical integration, and numerical analysis of integral and integrodifferential equations.
Building Competitive Advantage Through Halal Assurance System and Employee Performance
Authors: Fauzi Muchammad , Mujaddid Ade Yusuf 
Published: March 2023

By general destination from research this u for test and find out by real about influence implementation of HAS on employee performance and excellence Compete in Industrial Fast food in Central Java .Study this useful approach quantitative with the number of samples is 101 respondents. With purposive sampling technique, analyzed use descriptive and inferential with analysis technique with using Structural Equation Modeling (SEM) which is operated through the AMOS program. The results of this study are existence influence real that SJH will could explain happening enhancement performance employees. Show existence influence real that performance employee will could explain happening enhancement superiority compete. Show no existence influence real that SJH will could explain happening enhancement superiority compete. Sshow that in the industry food fast Halal certified fast food. Implementation of HAS in the production process capable create employees who produce high performance and performance employee proven take effect positive significant to superiority compete. That is, performance employee will also cause happening superiority compete.
Changes in Leptin to Adiponectin Ratio After Antiretroviral Therapy: A
Pilot Observational Study
Authors: Hikasa Shinichi , Shimabukuro Shota , Hideta Kyoko , Higasa Satoshi , Sawada Akihiro , Tokugawa Tazuko , Tanaka Kuniyoshi , Yanai Mina , Kimura Takeshi 
Published: March 2023

Aim:
Weight gain with the use of dolutegravir, bictegravir, and tenofovir alafenamide for
antiretroviral therapy has been reported. However, studies on changes in body composition and the
leptin/adiponectin ratio after antiretroviral therapy initiation are limited. These factors are important
because they can be used as indicators of metabolic syndrome and cardiovascular disease risk.

Introduction:
This study aimed to investigate the changes in waist circumference, body composition,
and adipokine levels after the initiation of antiretroviral therapy consisting of dolutegravir, bictegravir,
and tenofovir alafenamide and evaluate the relationships between these parameters in Japanese
patients living with human immunodeficiency virus.

Methods:
This is a single-center, prospective, observational study. Waist circumference, body composition,
and adipokine levels were measured at baseline and 12 months after antiretroviral therapy
initiation in antiretroviral therapy-naive Japanese patients living with human immunodeficiency virus.
Body composition was determined by bioelectrical impedance analysis.

Results:
We included 11 patients (10 bictegravir/TAF/emtricitabine, 1 dolutegravir/lamivudine) in
this study. The results showed no significant changes in waist circumference and body composition
among the patients. The leptin/adiponectin ratio and serum leptin levels significantly increased after
antiretroviral therapy initiation. Changes in waist circumference, fat mass, and visceral fat area
showed a strong positive correlation.

Conclusion:
The leptin/adiponectin ratio increased following antiretroviral therapy initiation. The
waist circumference measurement can be a simple, inexpensive, and useful method to identify changes
in fat mass and visceral fat area after initiation of antiretroviral therapy.
One-Step Preparation of Luteolin Nanoemulsion and Evaluation of its
Anti-inflammatory Effect in Animal Models
Authors: Karami-Mohajeri Somayyeh , Hashemi Narges , Ranjbar Mehdi , Mohajeri Mohammad , Sharififar Fariba 
Published: March 2023

Background:
Nanoemulsions are promising drug delivery systems for topical application
owing to the high transdermal penetration.

Objective:
Due to the side effects of existing anti-inflammatory drugs, much attention has been paid to
natural products such as flavonoids. The aim of this work was to formulate luteolin nanoemulsion
(LNE) and to evaluate its anti-inflammatory effect.

Methods:
LNE was prepared using the low-energy spontaneous emulsion method and characterized
by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy and dynamic
light scattering (DLS). The anti-inflammatory effect of LNE was assessed in formalin and acetic
acid-induced inflammation methods (Whittle test). Treatment with LNE (i.p, 4 consecutive days,
40 mg/kg) was compared with diclofenac 25 mg/kg and normal saline. In the formalin test, data were
recorded at 1, 2 and 4 hours after formalin injection and in the Wittle test, the extent of Evans blue
leakage in the peritoneal cavity was considered as vascular permeability.

Results:
Formalin-induced edema decreased in the LNE group, but this reduction was not significant
(p > 0.05), however, in Whittle test, both LNE and diclofenac significantly reduced Evans blue leakage
compared with the group treated with acetic acid alone (p < 0.05).

Conclusion:
Our results confirm the anti-inflammatory effect of LNE and give up a new platform for
the design and development of bio-based carriers for more successful drug delivery.
Role of Autophagy and Mitophagy in Neurodegenerative Disorders
Authors: Kapil Lakshay , Kumar Vishal , Kaur Simranjit , Sharma Deepali , Singh Charan , Singh Arti 
Published: March 2023

Abstract:
Autophagy is a self-destructive cellular process that removes essential metabolites and
waste from inside the cell to maintain cellular health. Mitophagy is the process by which autophagy
causes disruption inside mitochondria and the total removal of damaged or stressed mitochondria,
hence enhancing cellular health. The mitochondria are the powerhouses of the cell, performing essential
functions such as ATP (adenosine triphosphate) generation, metabolism, Ca2+ buffering, and signal
transduction. Many different mechanisms, including endosomal and autophagosomal transport, bring
these substrates to lysosomes for processing. Autophagy and endocytic processes each have distinct
compartments, and they interact dynamically with one another to complete digestion. Since mitophagy
is essential for maintaining cellular health and using genetics, cell biology, and proteomics techniques,
it is necessary to understand its beginning, particularly in ubiquitin and receptor-dependent signalling
in injured mitochondria. Despite their similar symptoms and emerging genetic foundations, Alzheimer's
disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral
sclerosis (ALS) have all been linked to abnormalities in autophagy and endolysosomal pathways associated
with neuronal dysfunction. Mitophagy is responsible for normal mitochondrial turnover and,
under certain physiological or pathological situations, may drive the elimination of faulty mitochondria.
Due to their high energy requirements and post-mitotic origin, neurons are especially susceptible
to autophagic and mitochondrial malfunction. This article focused on the importance of autophagy and
mitophagy in neurodegenerative illnesses and how they might be used to create novel therapeutic approaches
for treating a wide range of neurological disorders.
Crowd Detection System Using Blimp Drones as an Effort to Mitigate the Spread of Covid-19 Based on Internet of Things
Authors: Mashoedah Mashoedah , Dhewa Oktaf Agni , Roviyan Zulhakim Seftiyana , Leo Dheni , Masyitoh Silvia Larasatul 
Published: March 2023

The application of health protocols is a regulation that is applied to prevent the spread of Covid-19. Public awareness of the implementation of health protocols is still lacking. This study aims to determine the performance of the detection system using the Blimp Drone as an effort to mitigate the spread of Covid-19 based on the Internet of Things. The method used in system development consists of literature review, needs analysis, design, manufacture, and testing. This system uses the Blimp Drone as a vehicle to carry out flight missions. Raspberry pi camera as a component for distance detection in crowds and mask detection, and Flir Lepton 2.5 as a component for temperature detection. In addition, thealso used raspberry pi 4 is as a component for image processing of the distance detection system for crowd, mask, and temperature detection. The results of the tests carried out are: (1) the results of the analysis of the lifting power of the Blimp Drone using pure helium and a diameter of 0.91m capable of lifting a load of 0.45kg (2) the system can detect the distance of each person in the crowd (3) the system can detect everyone who using a mask and not wearing a mask (4) the system can detect the temperature of each person using image processing (5) an audio warning sounds when a person who is not wearing a mask is detected and the distance between 2 people in a crowd of less than 1 meter is detected (6) the advantages of this tool ie can work autonomous in flight missions to detect the distance the crowd, masks, and temperature, as well as integrated with system the Internet of Things so that data the results capturing can be accessed in real time for further action by the authorities.
The Automatic Monitoring System for WPP, SPP, and PLN based on The Internet of Things (IoT) using Sonoff Pow R2
Authors: Apriani Yosi , Bagaskara Muhammad Rama , Sofian Ian Mochamad , Oktaviani Wiwin A , Hurairoh Muhammad 
Published: March 2023

The usefulness of monitoring systems in the electric power system supports the importance of people's work today. One of which is the monitoring system at the generator. The monitoring system for Wind Power Plant (WPP), Solar Power Plant (SPP), and electricity from State Electricity Company (PLN) use IoT (Internet of Things) in the form of Sonoff Pow R2. With the monitoring system on this tool, the parameter values for WPP, SPP, and PLN can be seen and monitored online via a smartphone. The purpose of this research is to design a monitoring system for WPP, SPP, and PLN based on the Internet of Things (IoT) to determine the value of the output power. In addition, this system can distinguish load parameter values when WPP, SPP, and PLN are supplied directly (real time) and monitored online using the Sonoff Pow R2 app and the Ewelink App. This study uses the methodology that started the process of designing and manufacturing systems and designing the wiring that has been formed from the process of making tools and testing results. The results obtained from the experiment show that the current values in WPP, SPP, and PLN that appear on the monitoring screen are stable. The stable condition values are measured and tested when power is used when loading through sonoff. For the power value, the power value in PLN is stable, whereas in WPP and SPP has increased. For the voltage, the voltage value from PLN does not reach 220 V, whereas the voltage value from WPP and SPP reaches a value of 220 V.