bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing Effectiveness of Hyaluronic Acid-Chitosan Nanoparticles Encapsulation Versus Hyaluronic Acid Monotherapy in Osteoarthritis Rat Model: Microarray Screening for miR-140
Authors: Kamar Samaa Samir , ShamsEldeen Asmaa Mohammed , Hosny Sara Adel , El-Shafei Asmaa Ahmed , Rashid Laila Ahmad , Hassanein Radwa Taha , Hassan Rokia Mohamad 
Published: January 2023

AbstractOsteoarthritis is a debilitating, progressive joint disease linked to lower quality of life and higher health care costs. This study compared hyaluronic acid-chitosan nanoparticle encapsulation to hyaluronic-acid monotherapy in a rat model of knee osteoarthritis. Four groups of 40 adult male albino rats were designed. Group (Gp) I: control; Gp II (osteoarthritis model): intra-articular injection of monoiodoacetate; Gp III (hyaluronic acid-treated): intra-articular injections of hyaluronic-acid on days 14 and 21 after monoiodoacetate injection; and Gp IV (hyaluronic acid-chitosan nanoparticle-treated): intra-articular injections of hyaluronic acid-chitosan nanoparticle on days 14 and 21 after monoiodoacetate injection. After 28 days, knee joints were examined using H&E, Safranin O, and immunohistochemistry for nuclear factor kappa beta (NF-κB), inducible nitric oxide synthase (iNOS), and matrix metalloproteinase (MMP)-13. Quantification for gene expression of collagen-II, aggrecan, and micro-RNA-140; ELISA for interleukin (IL)-1β and IL-8; and western blotting for IKBα and NF-κB was estimated. Osteoarthritis-knee joints showed a severe cartilage damage and synovial inflammation with increased NF-κB, iNOS, and MMP-13 immunostaining, decreased miR-140, collagen II, and aggrecan levels, and increased inflammatory markers’ gene expressions. The hyaluronic acid-chitosan nanoparticle significantly improved knee joint structure and reduced inflammatory cytokines compared to hyaluronic acid monotherapy. Intra-articular injection of hyaluronic acid-chitosan nanoparticle encapsulation revealed a significant improvement in the knee joint structure compared to hyaluronic-acid in a rat model of osteoarthritis.
Preparation of High-Quality Samples for MEMS-BasedIn-Situ(S)TEM Experiments
Authors: Srot Vesna , Straubinger Rainer , Predel Felicitas , van Aken Peter A 
Published: January 2023

AbstractA novel focused ion beam (FIB)-based methodology for the preparation of clean and artifact-free specimens on micro-electro-mechanical-system (MEMS)-based chips for in-situ electrical and electro-thermal experiments in a (scanning) transmission electron microscope ((S)TEM) is introduced. Owing to an alternative geometry, the lamellae are attached to a MEMS-based chip directly after the lift-out procedure and afterward further treated or thinned to electron transparency. The quality of produced lamellae on a chip resembles the quality of a classical FIB-prepared sample that is here demonstrated by high-resolution STEM imaging and analytical techniques. Various sample preparation parameters and the performance of in-situ prepared samples have been evaluated through electrical-biasing experiments.
Dynamics of neutron star accretion columns in split-monopole magnetic fields
Authors: Zhang (力中张) Lizhong , Blaes Omer , Jiang (燕飞姜) Yan-Fei 
Published: January 2023

ABSTRACT
We perform 2D axisymmetric radiative relativistic MHD simulations of radiation pressure supported neutron star accretion columns in split-monopole magnetic fields. The accretion columns exhibit quasi-periodic oscillations, which manifest in the luminosity power spectrum as 2–10 kHz peaks, together with broader extensions to somewhat higher frequencies. The peak frequency decreases for wider columns or higher mass accretion rates. In contrast to the case of shorter columns in uniform magnetic fields, pdV work contributes substantially to maintaining the radiation pressure inside the column against sideways radiative cooling. This is in part due to the compression associated with accretion along the converging magnetic field lines towards the stellar surface. Propagating entropy waves which are associated with the slow-diffusion photon bubble instability form in all our simulations. Radial advection of radiation from the oscillation itself as well as the entropy waves is also important in maintaining radiation pressure inside the column. The time-averaged profile of our fiducial simulation accretion is approximately consistent with the classical 1D stationary model provided one incorporates the correct column shape. We also quantify the porosity in all our accretion column simulations so that this may also in principle be used to improve 1D models.
On the follow-up efforts of long-period transiting planet candidates detected with Gaia astrometry
Authors: Sozzetti A , Giacobbe P , Lattanzi M G , Pinamonti M 
Published: January 2023

ABSTRACT
The class of transiting cold Jupiters, orbiting at ≳0.5–1.0 au, is to-date underpopulated. Probing their atmospheric composition and physical characteristics is particularly valuable, as it allows for direct comparisons with the Solar system giant planets. We investigate some aspects of the synergy between Gaia astrometry and other ground-based and space-borne programs for detection and characterization of such companions. We carry out numerical simulations of Gaia observations of systems with one cold transiting gas giant, using Jovian planets around a sample of nearby low-mass stars as proxies. Using state-of-the-art orbit fitting tools, we gauge the potential of Gaia astrometry to predict the time of transit centre Tc for the purpose of follow-up observations to verify that the companions are indeed transiting. Typical uncertainties on Tc will be on the order of a few months, reduced to several weeks for high astrometric signal-to-noise ratios and periods shorter than ∼3 yr. We develop a framework for the combined analysis of Gaia astrometry and radial-velocity data from representative ground-based campaigns and show that combined orbital fits would allow to significantly reduce the transit windows to be searched for, down to about ±2 weeks (2–σ level) in the most favourable cases. These results are achievable with a moderate investment of observing time (∼0.5 nights per candidate, ∼50 nights for the top 100 candidates), reinforcing the notion that Gaia astrometric detections of potentially transiting cold giant planets, starting with Data Release 4, will constitute a valuable sample worthy of synergistic follow-up efforts with a variety of techniques.
Employing the policy capacity framework for health system strengthening
Authors: Saddi Fabiana da Cunha , Peckham Stephen , Bloom Gerald , Turnbull Nick , Coelho Vera Schattan , Denis Jean-Louis 
Published: January 2023

Abstract
The policy capacity framework offers relevant analytical ideas that can be mobilized for health system strengthening. However, the employment of this framework in the health field constitutes a relevant interdisciplinary gap in knowledge. This themed issue explores the relationships between the policy capacity framework and health system strengthening, in a multidimensional and interdisciplinary way, in high-income and low–middle-income countries. This introduction unpacks the dynamic interrelationships between the policy capacity framework and health system strengthening, bringing together common and distinct elements from both fields and summarizing possible relationships between them. The analysis shows that both fields together can increase our knowledge on health policies and system’s critical themes and reforms. This challenge could be followed by exploring the convergences between them, as far as concepts/themes (types of capacities and other themes) and levels of analysis are concerned. Although in varied ways, papers in this issue (based on European countries, China, Canada, New Zealand, India, Australia, and Brazil) advance the use of the policy capacity framework for health policy or system strengthening. They give two main interdisciplinary contributions. Critical capacities can be incorporated into the policy capacity framework for the analysis of system strengthening—capacity to adapt, contexts of mixed and complex systems, dynamic view of policy capacity, and policy capacity as a relational power. Policy capacity is contextually interpreted (relative to the problem frame) and dynamic and adaptive (processual and relational), in relation to the properties of a health system, particularly with regard to the existing and developing mixed and complex systems.
Updated constraints on sterile neutrino mixing in the OPERA experiment using a new νe identification method
Authors:   OPERA Collaboration, Agafonova N , Alexandrov A , Anokhina A , Aoki S , Ariga A , Ariga T , Bertolin A , Bozza C , Brugnera R , Buontempo S , Chernyavskiy M , Chukanov A , Consiglio L , D’Ambrosio N , De Lellis G , De Serio M , del Amo Sanchez P , Di Crescenzo A , Di Ferdinando D , Di Marco N , Dmitrievsky S , Dracos M , Duchesneau D , Dusini S , Dzhatdoev T , Ebert J , Ereditato A , Fini R A , Fukuda T , Galati G , Garfagnini A , Gentile V , Goldberg J , Gorbunov S , Gornushkin Y , Grella G , Guler A M , Gustavino C , Hagner C , Hara T , Hayakawa T , Hollnagel A , Ishiguro K , Iuliano A , Jakovčć K , Jollet C , Kamiscioglu C , Kamiscioglu M , Kim S H , Kitagawa N , Kliček B , Kodama K , Komatsu M , Kose U , Kreslo I , Laudisio F , Lauria A , Longhin A , Loverre P , Malgin A , Mandrioli G , Matsuo T , Matveev V , Mauri N , Medinaceli E , Meregaglia A , Mikado S , Miyanishi M , Mizutani F , Monacelli P , Montesi M C , Morishima K , Muciaccia M T , Naganawa N , Naka T , Nakamura M , Nakano T , Niwa K , Ogawa S , Okateva N , Ozaki K , Paoloni A , Paparella L , Park B D , Pasqualini L , Pastore A , Patrizii L , Pessard H , Podgrudkov D , Polukhina N , Pozzato M , Pupilli F , Roda M , Roganova T , Rokujo H , Rosa G , Ryazhskaya O , Sato O , Schembri A , Shakiryanova I , Shchedrina T , Shibayama E , Shibuya H , Shiraishi T , Simone S , Sirignano C , Sirri G , Sotnikov A , Spinetti M , Stanco L , Starkov N , Stellacci S M , Stipčevic M , Strolin P , Takahashi S , Tenti M , Terranova F , Tioukov V , Tufanli S , Vasina S , Vilain P , Voevodina E , Votano L , Vuilleumier J L , Wilquet G , Yoon C S 
Published: January 2023

Abstract
This paper describes a new νe identification method specifically designed to improve the low-energy ($\lt {30}\, {\rm GeV}$) νe identification efficiency attained by enlarging the emulsion film scanning volume with the next-generation emulsion readout system. A relative increase of 25–70% in the νe low-energy region is expected, leading to improvements in the OPERA sensitivity to neutrino oscillations in the framework of the 3 + 1 model. The method is applied to a subset of data where the detection efficiency increase is expected to be more relevant, and one additional νe candidate is found. The analysis combined with the ντ appearance results improves the upper limit on sin 22θμe to 0.016 at 90% C.L. in the MiniBooNE allowed region $\Delta m^2_{41} \sim {0.3}\, {\rm eV}^{2}$.
Informing the development of the coaching online and community health (COACH) program: a qualitative study of clubhouse members living with serious mental illness
Authors: O’Neill Kathryn , Hand Rachel , Diop Betty , Weiss Holly , Cruz Pfaeffle Andrea , Maragatham Parameshwari , Rice Kevin , Naslund John A 
Published: January 2023

Abstract
Health and wellness interventions addressing risk factors for early mortality among individuals with serious mental illness have demonstrated success and can be further augmented with digital technology. These programs may be suitable for delivery in psychosocial rehabilitation clubhouses, especially given many services have transitioned to digital platforms during the pandemic. This qualitative study aimed to: (a) explore clubhouse members’ experiences engaging with the virtual clubhouse platform, and their preferences for accessing digital wellness and health promotion content; and, (b) gauge members’ interest in an online peer-driven lifestyle intervention and their suggestions for program design. This study was guided by a community-based participatory action research framework. Ten focus groups were conducted with clubhouse members. Focus groups were coded and analyzed thematically by trained clubhouse members and the research team. Thirty-three members participated in the focus groups. Participants expressed the importance of having technical support from staff; that one-on-one support and consistent communication are important to keep them engaged in health and wellness programming; and described mixed views about use of the virtual platform, but generally were open to engaging in lifestyle intervention programming virtually. Participants who joined the clubhouse during the pandemic expressed feeling overwhelmed by in-person gatherings, and were especially interested in opportunities for remote participation. This study can inform health and wellness programming for delivery on the virtual clubhouse platform for members. The taxonomy of codes, created to generate a framework with recommendations, will inform the design of a virtual health and wellness intervention.
Practice patterns and perspectives regarding treatment for symptoms of menopause: qualitative interviews with US health care providers
Authors: DePree Barbara , Houghton Katherine , DiBenedetti Dana B. , Shiozawa Aki , King Deanna D. , Kim Janet , Mancuso Shayna 
Published: January 2023

Abstract

Objective
To document health care providers' views regarding treatments for symptoms associated with menopause and discussions with patients about symptoms and treatment decisions. Results informed development of a data collection form for a retrospective medical record review (reported separately).

Methods
Registered US gynecologists or primary care providers from all US regions were identified from local association directories and an in-house database and were invited to participate in a qualitative interview if they consulted with three or more patients per week presenting with menopausal symptoms. Participants provided demographic data, information about patients' symptoms, and health care provider and patient views on prescription and nonprescription therapies. Key concepts/themes from interviews were identified.

Results
Participating health care providers (10 gynecologists, 10 primary care providers) agreed there are effective treatment options for menopausal symptoms, particularly vasomotor symptoms and vaginal dryness and/or atrophy. Health care providers reported that treatment was generally dictated by symptoms that interfered with quality of life and/or daily activities, although patients often had symptoms for months before presentation. All health care providers said they prescribe hormone and/or nonhormone therapies for treatment of menopausal symptoms; half stated that they typically inquire about patients' nonprescription therapy use, and 45% recommend specific nonprescription therapies. The most commonly cited barriers to initiation of any therapy for menopausal symptoms were patient concerns about risks and financial considerations (ie, insurance or cost).

Conclusions
US health care providers reported prescribing therapies for menopausal symptoms and noted that these therapies were perceived as generally effective; however, barriers to initiation of prescription therapy exist, and new treatment options are needed.
Loss of muscle mass in women with premature ovarian insufficiency as compared with healthy controls
Authors: Li Saisai , Ma Linjuan , Huang Haiying , Lou Zheng , Qi Tongyun , Huang Yizhou , Zou Yu , Zhou Jianhong 
Published: January 2023

Abstract

Objective
Menopausal transition has been known to be associated with the loss of muscle mass. However, muscle health in women with premature menopause, that is, premature ovarian insufficiency (POI), remains unclear. We aimed to investigate and compare muscle mass parameters and the prevalence of low muscle mass between patients with spontaneous POI and healthy controls.

Methods
In this cross-sectional study, 59 women with spontaneous POI and 57 premenopausal controls with normal ovarian function were enrolled at the Women's Hospital, Zhejiang University School of Medicine (Hangzhou, China) from June 17, 2020, to August 20, 2021. Muscle mass parameters were measured by dual-energy x-ray absorptiometry, and low muscle mass was diagnosed using the Asian Working Group for Sarcopenia criteria. In addition, participants provided their sociodemographic data, menstrual and reproductive history, lifestyle factors, and medical history. Multivariate linear regression analysis was conducted.

Results
Muscle mass parameters, including appendicular skeletal muscle mass (ASM), ASM/height2, ASM/weight, ASM/body mass index, total skeletal muscle mass (TSM), and TSM/weight, were significantly lower in women with POI as compared with healthy controls (ASM: 14.62 ± 2.08 vs 15.97 ± 1.78, P < 0.001; ASM/height2: 5.71 ± 0.64 vs 6.15 ± 0.62, P < 0.001; ASM/weight: 0.27 [0.25, 0.28] vs 0.28 [0.27, 0.29], P = 0.002; ASM/BMI: 0.68 ± 0.07 vs 0.73 ± 0.06, P = 0.001; TSM: 33.85 ± 4.08 vs 36.43 ± 3.56, P < 0.001; TSM/weight: 0.63 [0.59, 0.65] vs 0.64 [0.61, 0.67], P = 0.02). The prevalence of low muscle mass in POI patients was significantly higher than that in controls (32.20% vs 8.77%, χ
2 = 9.70, P = 0.002). Furthermore, multivariate linear regression analyses demonstrated that POI status was an independent risk factor for ASM (β = −1.13; 95% CI, −1.62 to −0.65), ASM/height2 (−0.35, −0.47 to −0.22), ASM/weight (−0.01, −0.02 to −0.009), ASM/BMI (−0.05, −0.07 to −0.02), TSM (−2.16, −3.14 to −1.17), and TSM/weight (−0.03, −0.04 to −0.02).

Conclusions
Women with POI exhibit significant loss of muscle mass as compared with healthy controls. Early diagnosis and long-term health management in POI patients are important.
Enzymatic Debridement in Severe Burn COVID-19 Patients: A Case Series
Authors: Coletta Francesco , Sala Crescenzo , De Marco Giovanna Paola , Mataro Ilaria , Petroccione Carlo , Bonagura Pietro , Pirolli Rossella , Foreste Giuseppe , Tomasello Antonio , Villani Romolo 
Published: January 2023

Summary:
The presence of a high number of positive SARS-CoV-2 patients is found daily in the emergency room database, finding evidence of infection also in trauma and burns. Surgical debridement remains the gold standard for eschar removal, but it does not come without complications such as bleeding and high heat loss. In recent years, there has been an increase in the use of enzymatic debridement techniques, replacing surgical escharotomy. Early eschar removal is proven to be important; it has been proved that an early and effective burn treatment in COVID-19 patients can reduce other infection. Five clinical cases of patients arrived at our COVID-19 Major Burns Intensive Care Unit. On admission, burns extension and depth were assessed by an expert burn surgeon. We evaluated eschar removal modality, adverse events, and potential side effects. Enzymatic debridement was efficient in all patients treated with complete eschar removal, and no serious adverse events. All patients were treated within 24 hours of arrival at our facility with Nexobrid by specialized personnel in deep sedation and with O2 support using a face mask or nasal goggles. The use of enzymatic debridement in COVID-19–positive burn patients within dedicated pathways through nonsurgical treatment optimizes the treatment time. We believe that the use of enzymatic debridement could be a valid therapeutic option in burn patients, even with SARS-CoV-2 infection, and its use, when indicated, is safe and effective for the patient and optimizes the use of instrumental and human resources in a pandemic emergency.
SYMPTOMATIC EARLY-ONSET X-LINKED RETINOSCHISIS
Authors: Piquin Gwendoline , Abdelmassih Youssef , Martin Gilles , Edelson Catherine , Metge Florence , Caputo Georges , Chapron Thibaut 
Published: January 2023

Purpose:
To describe clinical characteristics and outcomes of children with early-onset X-linked retinoschisis.

Methods:
In this retrospective consecutive case series, we included children diagnosed with symptomatic X-linked retinoschisis younger than 2 years. Presenting signs, clinical characteristics, treatments, and outcomes were recorded.

Results:
Seven patients (14 eyes) with a mean age of 17.14 ± 6.28 months were included. Strabismus was the most common presenting symptom (6 of 7 patients, 86%). Clinical signs at the first diagnosis included peripheral retinoschisis in 13 eyes (13/14, 93%), of which 5 (5/13, 38%) were bullous, vitreous hemorrhage in 3 eyes (3/14, 21%), and retinal detachment in 3 eyes (3/14, 21%). The macula was involved in all eyes: It was detached in 2 eyes (2/14, 14%) and involved in the peripheral schisis in 4 eyes (4/14, 29%). In all remaining eyes, optical coherence tomography revealed foveoschisis. Six eyes (6/14, 42%) received surgery. At the last follow-up, visual acuity, when available, ranged from no light perception to 20/40, and no children had persistent retinal detachment.

Conclusion:
Children with early-onset X-linked retinoschisis had severe forms. All children had peripheral retinoschisis which was often bullous and extended to the macula. Diagnosis is often clinical but handheld optical coherence tomography can be helpful in atypical forms. Complications requiring surgical management are frequent.
EPIRETINAL MEMBRANE WITH FOVEAL HERNIATION
Authors: Shah Saumya M. , Eliott Dean , Cox Jacob T. , Yonekawa Yoshihiro , Mahmoudzadeh Raziyeh , Peck Travis J. , Regillo Carl D. , Ho Allen C. , Oellers Patrick , Choudhury Mahin , Arboleda Nathan , Gentile Ronald C. , Sun Vincent , Iezzi Raymond 
Published: January 2023

Purpose:
Foveal herniation occurs when neuroretinal tissue protrudes through and above the level of an epiretinal membrane. This study describes the visual symptoms and spectral domain optical coherence tomography findings associated with foveal herniation and evaluates the postoperative visual, anatomical, and surgical outcomes.

Methods:
A multicenter retrospective review of patients diagnosed with epiretinal membrane identified 59 patients with preoperative foveal herniation on spectral domain optical coherence tomography. Data regarding visual symptoms, preoperative and postoperative best-corrected visual acuity (BCVA), central retinal thickness, macular volume, and size of foveal herniation were collected, and statistical analysis was performed.

Results:
A total of 58 of the 59 patients with foveal herniation underwent surgical epiretinal membrane peeling, with foveal contour restored in 53.5% of patients after surgery. Average BCVA improved from 20/80 to 20/40 Snellen equivalent at most-recent postoperative visit (P < 0.0001). The average central retinal thickness decreased from 632 µm to 432 µm (P < 0.0001) and the average macular volume decreased from 11.3 mm3 to 9.5 mm3 (P < 0.0001) at 3 months postoperatively. Preoperatively, greater herniation height was associated with worse BCVA (P = 0.008), greater central retinal thickness (P = 0.01), retinoschisis, cystoid macular edema, foveolar detachment, ellipsoid zone abnormality, and external limiting membrane abnormalities (P < 0.05). Postoperatively, there was a decrease in retinoschisis, cystoid macular edema, foveolar detachment, ellipsoid zone, and external limiting membrane abnormality (P < 0.05) on spectral domain optical coherence tomography.

Conclusion:
Patients with larger foveal herniation height had greater preoperative central retinal thickness, worse preoperative and postoperative BCVA, and more intraretinal abnormalities on spectral domain optical coherence tomography. Surgical epiretinal membrane peeling in patients with foveal herniation resulted in a significant improvement in patients' BCVA and microstructural abnormalities.