bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Itgb1 as a critical gene for radiation-induced injury by bioinformatic analysis combined with experimental verification
Authors: Zhang Cheng , Xiao Ning , Du Baiyinzi , Jiang Keer , Lin Yuhan , Yao Liuhuan , Liu Ruling , Liu Hu , Yuan Xuefei , Li Bailong , Cai Jianming 
Published: May 2023

Abstract

Radiation injury is a common side effect of nuclear and radiation accidents as well as clinical oncologic radiotherapy. The organism undergoes a series of pathological responses after irradiation, especially in the short term, accompanied by an intense inflammatory storm [1], and effective targets for intervention have not been identified [2]. In this study, we screened differential genes in gene microarray data from the GEO database and then identified the core gene Itgb1 by enrichment analysis. Subsequently, the expression of Itgb1 was knocked down by siRNA interference and was functionally blocked by RGD, a Itgb1 inhibitor. Next, the proliferation and apoptosis of irradiated cells was detected, and injury of lung tissues and hemopoietic system were also investigated. As a result, knockdown of Itgb1 protected pulmonary epithelial cells and blood cell from irradiation, and RGD remitted the irradiation-induced lung injury and hematopoietic injury. This study suggests that Itgb1 plays a key role in radiation injury and provides new ideas for the prevention and treatment of radiation therapy.
Digital Governance in the Internet of Things Context. Evidence from the EU, MENA and BRICS:
Authors: Covaci Brindusa , Covaci Mihai 
Published: May 2023

Abstract
Digital governance evolved considerably in the last decades, especially in the context of the 6G generation. Information Technology (IT) transformed humanity and the general paradigms of human beings. More, the Internet of Things (IoT) reframes the socio-economic environment. The paper analyses the specific context of digital governance from countries relevant to the mountain area belonging to the EU, MENA, and BRICS. The results revealed that the proposed hypothesis and indicators were validated. Digital governance offers the right way for leaders to focus on other responsibilities, rather than a decision-making network. The research proposes five new public and private governance indicators, especially for the IT dimension. The EU, MENA, and BRICS countries could follow standard IT governance models. Public and private governance becomes the strongest defense system against socioeconomic chaos and failure.
JEL codes: D73, G34, L86
Correlation between plasma saturated fatty acids and atrial fibrillation in a Chinese population
Authors: Jin Hui , Tao Yi-rao , Wang Xin-ke , Jiang Zong-dian , An Shuo , Yang Dong-hui 
Published: May 2023

Abstract
Background To investigate the correlation between plasma saturated fatty acids (SFA) and atrial fibrillation (AF) in a Chinese population.Methods A total of 486 patients with atrial fibrillation who were admitted to the Cardiology Department of the Second Affiliated Hospital of Dalian Medical University from June 2020 to May 2021 were enrolled in this retrospective study. An additional 486 individuals without atrial fibrillation who were matched for age and sex were selected as the control group. Data on the body mass index (BMI), history of smoking, alcohol consumption, hypertension, diabetes, coronary heart disease, heart failure, stroke, lipid-lowering therapy, and tumour history were collected from both groups. Plasma SFA levels were measured in both groups, including lauric acid (C12:0), myristic acid (C14:0), palmitic acid (C16:0), stearic acid (C18:0), arachidic acid (C20:0), behenic acid (C22:0), lignoceric acid (C24:0), total SFA, and other plasma fatty acid levels. Differences in general clinical indicators and fatty acids were compared between the two groups, and stepwise logistic regression was used to determine whether SFA was an independent correlate of atrial fibrillation. Plasma SFA levels were categorized and evaluated using quartiles as the reference index.Results After adjusting for other risk factors for atrial fibrillation, higher levels of plasma C16:0, C20:0, and total SFA were found to be independent correlates of atrial fibrillation and possibly also protective factors. The odds ratios [ORs] for the second and third quartiles of C16:0 compared to the lowest quartile were 0.481 (95% confidence interval [CI]: 0.256–0.905) and 0.366 (95% CI: 0.182–0.734); those for the third and fourth quartiles of C20:0 compared to the lowest quartile were 0.497 (95% CI: 0.275–0.898) and 0.514 (95% CI: 0.282–0.938); and those for the second and third quartiles of total SFA compared to the lowest quartile were 0.518 (95% CI: 0.277–0.967) and 0.372 (95% CI: 0.187–0.739), respectively (all P < 0.05).Conclusion Different SFAs may serve as circulating biomarkers for the diagnosis and prediction of atrial fibrillation.
Strategy for acute DeBakey type Ⅰ aortic dissection considering midterm results: A retrospective cohort study comparing ascending aortic replacement and total arch replacement with frozen elephant trunk technique
Authors: Takagi Sho , Goto Yoshihiro , Yanagisawa Junji , Ogihara Yui , Okawa Yasuhide 
Published: May 2023

Abstract
Background
Acute type A aortic dissection is treated with an emergency procedure that uses ascending aortic replacement (AAR). However, to avoid a residual dissected aorta with a false lumen, total arch replacement (TAR) is required. The frozen elephant trunk (FET) technique is a promising surgical approach that promotes false lumen obliteration in a single step without increasing operative risk. Therefore, this retrospective single-center study aimed to evaluate the operative outcomes of AAR and TAR with FET.
Methods
Between 2007 and 2021, 143 patients with acute DeBakey type Ⅰ aortic dissection underwent a central repair using AAR (n = 95) or TAR with FET (n = 43). All perioperative variables, the duration of all-cause mortality, and aortic events defined as dilatation of the distal aorta > 5 cm, new occurrences of aortic dissection, distal aortic surgery, and distal aortic rupture were recorded. We compared these patients' perioperative variables and mid-term results with an additional focus on distal aortic events.
Results
Patient background data did not differ between the two groups. Perioperative results for the TAR with FET group vs the AAR group showed similar operative times (306 vs 298 min, P = 0.862), but the TAR group had longer cardiopulmonary bypass times (154 vs 179 min, P < 0.001). The freedom from all-cause death for the TAR vs AAR groups using the Kaplan-Meier method was 81.9% vs 85.4% and 78.0% vs 85.4% (P = 0.407) at 1 and 3 years, respectively, and freedom from aorta-related events was 90.6% vs 97.6% and 69.3% vs 87.0% (P = 0.034) at 1 and 3 years, respectively.
Conclusions
TAR with FET had comparable perioperative results to AAR in acute DeBakey type Ⅰ aortic dissection and was considered a valuable method to avoid aorta-related events in the midterm.
Platelets as a prognostic factor for patients with adenocarcinoma of the gastroesophageal junction
Authors: Feka Joy , Jomrich Gerd , Winkler Daniel , Ilhan-Mutlu Ayseguel , Kristo Ivan , Paireder Matthias , Rieder Erwin , Bologheanu Milena , Asari Reza , Schoppmann Sebastian F. 
Published: May 2023

Abstract
Objective: Aim of this study was to investigate the prognostic role of plasma platelet count (PLT), mean platelet volume (MPV) and the combined COP-MPV score in patients with resectable adenocarcinomas of the gastroesophageal junction.
Background: Platelet activation, quantified by PLT and elevated MPV, plays an essential part in the biological process of carcinogenesis and metastasis. An increased preoperative COP-MPV is associated with poor survival in various tumour entities.
Methods: Data of 265 patients undergoing surgical resection for adenocarcinoma of the gastroesophageal junction were abstracted. COP-MPV score was defined for each patient. Utilizing univariate and multivariate COX proportional hazard analyses, survival was determined.
Results: In univariate analysis, elevated PLT (HR 3.58, 95% CI 2.61-4.80, P<0.001) and increased COP-MPV (HR 0.27, 95% CI 0.17-0.42, P<0.001 and HR 0.42, 95% CI 0.29-0.60, P<0.001) significantly correlated with shorter patients overall and disease-free survival, for all 256 patients, as well as in the subgroups of neoadjuvantly treated (p<0.001) and primarily resected patients (p<0.001). COP-MPV remained a significant prognostic factor in multivariate analysis for OS. However, PLT alone showed significant diminished OS and DFS in all subgroups (p<0.001) in univariate and multivariate analysis.
Conclusion: PLT is a potent independent prognostic biomarker for survival in a large prospective cohort of patients with resectable adenocarcinoma of the gastroesophageal junction. Additionally, we confirm that the COP- MPV score is significantly associated with worse outcome in these patients, but has no benefit in comparison to PLT.
Dickkopf1 (DKK1) as a Potential Biomarker in Polycystic Ovary Syndrome and Insulin Resistance: A Cross-Sectional Study
Authors: Li Shengbing , Wang Hao , Li Ke , Liu Rui , Qiu Sheng , Lei Xiaotian , Yang Mengliu , Lai Yerui , He Jianguo , Liang Zerong 
Published: May 2023

Abstract
Background: Dickkopf1 (DKK1) isa protein with established links to metabolic diseases. However, its association with polycystic ovary syndrome (PCOS) and insulin resistance (IR) remains ambiguous.
Methods: We conducted a cross-sectional study involving 300 participants, including 100 healthy women, 100 women with PCOS, and 100 individuals with IR. We used the STRING database to identify proteins that interact with DKK1 and performed KEGG and GO analyses to determine the biological processes and signaling pathways that are enriched in DKK1-related proteins. Serum DKK1 levels and Adipoq were measured by ELISA kits. The expression of DKK1 in liver tissue wasdetected by western blotting.
Results: Relative to the control group, both the IR and PCOS cohorts exhibited markedly elevated serum DKK1 levels and noticeably reduced Adipoq levels. Correlation analyses revealeda positive relationship between serum DKK1 levels and body mass index(BMI), waist-hip ratio (WHR), body fat percentage (FAT%), systolic blood pressure (SBP), triglycerides (TG), fasting plasma glucose (FPG), fasting insulin (FIns), glycosylated hemoglobin (HbA1c), and homeostasis model assessment of insulin resistance (HOMA-IR) and a negative relationship between Adipoq levels and M-value. Multiple regression analysis indicated that BMI, FAT%, TG, and Adipoq were independent factors affecting DKK1. An analysis of multiple stepwise regressions revealed that DKK1 was a risk factor for IR and PCOS. In the euglycemic-hyperinsulinemic clamp (EHC) test, serum DKK1 levels exhibited a significant increase in the PCOS patients and a pronounced decrease in the IR patients at 30 minutes and returned to baseline at 60 minutes.
Conclusions: Our research revealedthat an increase in DKK1 levels in the blood was significantly associated with PCOS and IR, thereby highlighting the potential involvement of DKK1 in the pathogenesis of PCOS and IR. This insight paves the way for further investigations into the role of DKK1 in PCOS and IR.
Fathering a premature baby
Authors: BENNAOUI F. , LALAOUI A. , SLITINE N. ELIDRISSI , MAOULAININE F. M. R. 
Published: May 2023

Abstract
The hospitalization of premature infants is a difficult and anxiety-provoking experience for parents. Studies on the mother's experience are becoming increasingly numerous, while the father's experience remains little studied. Objective: To explore the experiences of fathers of premature infants and the psychopathological and social consequences following the birth of their children. A qualitative and quantitative study was carried out in the neonatology department of the Mohammed VI University Hospital in Marrakech among 80 men whose prematurely born child was still hospitalized in the neonatology department. 2 questionnaires were administered: the IES-R and the EPDS, and a semi-directive interview was also conducted. Several aspects were highlighted, such as the difficult experience of premature birth and hospitalization, and the ambivalence of returning home. The importance of establishing a positive father-child relationship, social support and the versatility of the father's role. Premature birth has a less traumatic impact on fathers. Promoting father/child contact and encouraging specific care could help men to take on their role as fathers, which is sometimes difficult to integrate.
Comparative Metabolic Study of two types of R. Cohrysanthums under UV-B Stress
Authors: Yu Wang , Gong Fushuai , Sun Li , Cao Kun , Xu Hongwei , Zhou Xiaofu 
Published: May 2023

Abstract
Background
Rhododendron chrysanthum Pall (R. chrysanthum.), a plant with UV-B resistance mechanisms that can be adapted to alpine environments, has gained attention as an important plant resource with the ability to cope with UV-B stress. Research on the complex mechanism of plant adaptation to UV-B will be aided by these results.
Results
In this study, metabolomics analysis and physiological measurements were used to reveal the response of Rhododendron chrysanthumseedlings to UV-B stress. After UV-B irradiation, 404 metabolites were detected. The domesticated R. chrysanthum had high amino acid and SOD content.
Conclusions
The study shows that the domesticated R. chrysanthum showed significant UV-B resistance. 26 of these different metabolites were classified as UV-B-responsive metabolites. Glyceric acid is used as a potential UV-B stress biomarker.
Higher-order statistical learning for joint motion estimation and segmentation in video
Authors: ALAOUI El Mehdi ISMAILI 
Published: May 2023

Abstract

The paper describes a scheme for moving objects in image sequence. The scheme adopts a distribution-based model approach to moving object detection. The methodology involves pattern classification using higher-order statistics (HOS) in a clustering framework. The proposed method effectively combines statistical knowledge about the class of moving objects with motion information. The unknown distribution of the image patterns of objects is approximately modeled using HOS information derived from sample images. Our proposed algorithm uses an HOS-based decision measure which is derived from a series expansion of the multivariate probability density function in terms of the multivariate Gaussian and the Hermite polynomial. A data clustering that uses HOS is proposed to facilitate the decision process. The higher-order closeness measure is used to classify test clusters as foreground or background.
WITHDRAWN: Bamboo as Potential Substrate for Sea Cage Culture of Abalone Haliotis asinina
Authors: Creencia Lota A. , Alcantara Lutgardo B. , Juan Riza G. San 
Published: May 2023

Abstract
Abalone is highly priced marine gastropod in both domestic and overseas markets, but increased fishing pressure has caused a significant decline in the wild abalone population. To meet market demand, there is increasing interest in the cage culture of abalone juveniles. However, the use of polyvinyl chloride (PVC) substrate, the most used substrate in cage culture, has been associated with environmental and health risks. Thus, this study investigated the potential of bamboo slat (BS) as an alternative substrate for the bottom sea cage culture and suspended sea cage culture of tropical abalone Haliotis asinina fed with the red seaweed Gracilaria firma. The results showed, during the 60–120 days of culture, abalone juveniles grown with BS substrate had significantly higher weight gain and specific growth rate compared to those reared with PVC substrate (p < 0.05). Nevertheless, the t-test conducted on day 150 indicated that the mean weight of abalone juveniles with the BS substrate was not significantly different from those with PVC substrate. The findings also indicate that abalone juveniles grown with BS substrate had significantly higher shell length growth rates than abalone juveniles grown with PVC substrate (p < 0.05). In addition, abalone juveniles on BS substrate showed positive allometric growth after 90 days and 150 days of culture compared to abalone juveniles on PVC substrates, which showed isometric growth. Furthermore, the t-test showed that survival rates of abalone juveniles with BS substrate are not significantly different compared with abalone juveniles with PVC substrate (p < 0.05). Since abalone juveniles cultured in cages with BS substrate have high growth and survival rates; thus, they are recommended as an alternative for abalone juvenile culture because they are indigenous, inexpensive, and environmentally safe.
Dietary Clostridium butyricum enhances antioxidant capacity by altering intestinal flora in broilers
Authors: Wang Simeng , Shen Jiakun , Ji Linbao , Zhang Lian , Zhang Xin , Ma Xi , Nie Cunxi , Wang Pei 
Published: May 2023

Abstract

Recently, there has been a growing interest in usingClostridium butyricum(C. butyricum) as an alternative to antibiotics, Because of its prospective benefits in strengthening the intestinal barrier and promoting broiler growth, the current research focused on understanding the impacts ofC. butyricumsupplementation on growth attributes, antioxidant capability, and intestinal microbiota in AA broilers. In this study, a control group (Con) and aC. butyricumgroup (Cb) were randomly established from a sample of 120 AA broilers. The basic diet for the Con group, in contrast, the Cb group's diet was the same but included a supplement of 2.88×109CFU/gC. butyricum. (SLZX19-05, CN113583915B). The study showed that incorporatingC. butyricumled to notable advancements in the growth and digestive abilities of AA broilers while effectively diminishing oxidative stress. High-throughput sequencing indicated thatC. butyricumprovided protective effects on the diversity of intestinal microflora, particularly increasing ileal intestinal microflora diversity. Lefse analysis revealed that the abundance ofOscillospiraceae,Butyricoccaceae, andLactobacillusin the Cb group increased. Correlation analysis between intestinal microflora and antioxidant indicators suggested thatC. butyricumsupplementation might enhance antioxidant levels by increasingLactobacillusabundance, especially the level of superoxide dismutase (SOD). Based on this study, supplementing AA broilers withC. butyricummay improve growth performance, digestive capacity, antioxidant capacity, and intestinal microflora regulation. These findings offer new insights into the role ofC. butyricumin enhancing antioxidant capacity and provide a foundation for understanding the relationship between intestinal microflora and antioxidant.
Survival Outcome and Prognostic Factors Post Inadvertent Hysterectomy in Carcinoma Cervix Treated With Salvage Chemo-Radiation
Authors: Mishra Ritusha , Pandey Ankita , Mishra Himanshu , Singh Shreya , Jain Pallavi , Singh Tej Bahadur , Mandal Abhijeet , Singh Pramod Kumar 
Published: May 2023

Abstract
Introduction:
The standard of care for treating early invasive cervical cancer is radical hysterectomy or radiation alone while chemo-radiation is a definitive treatment for advanced disease. Occasionally, simple hysterectomy is performed in cancer cervix and these patients merit adjuvant treatment in view of high chances of loco-regional recurrences. Aim of the study was to analyze the survival outcome of these patients treated with salvage chemo-radiotherapy and also to determine the prognostic factors affecting survival.
Materials and methods
The medical records of all patients of cervical cancer post simple hysterectomy outside and who received salvage treatment in our department between 2014 and 2020 were retrieved. The data regarding clinical, treatment details and survival were analyzed.
Results
A total of 198 patients were included. Median follow up duration was 45.5 months. Gross disease and lymphadenopathy was seen in 60% and 28% patients, respectively. The 5-year progression free survival(PFS) and overall survival(OS) was 75% and 76%, respectively. Concurrent chemotherapy alone or in combination with induction chemotherapy using three drug regimens showed better survival compared to those treated by radiation alone. On multivariate analysis, factors found to be adversely affecting OS and PFS were lymph node (LN) size of more than 2cm, non squamous histology, overall treatment time(OTT) of more than 12 weeks and use of non three drug chemotherapy regimen.
Conclusion
Subtotal hysterectomy results in higher incidence of local recurrence of disease. Factors that impair the outcome in this sub-group of patients are gross lymphadenopathy, non-squamous histology and prolong OTT.
Beamforming Design and Power Allocation Aided by Relay Selection in Cooperative Massive MIMO Network
Authors: Hassan Jamal A. , Ghoreishian MJ. 
Published: May 2023

Abstract
In this paper, we study the relay selection and power allocation to maximize the achievable sum rate of all the users in the cooperative Massive Multiple Input-Multiple Output (mMIMO) system. Some users have direct paths to the base station (BS) to communicate in the considered system model. In contrast, there is no direct path for the rest users, and the relay helps transmit information signals from BS to these users (indirect users). Firstly, we design a beamforming matrix at BS and relay according to the block diagonalization (BD) and Zero-Forcing (ZF) methods, respectively. Then, relay selection and power allocation problems are analyzed. Generally, the joint power allocation and relay selection problem is a combinatorial problem, and it needs a global search algorithm to solve, which is complex and time-consuming. Therefore, we convert this joint problem into two sub-problems. The first sub-problem selects the suitable relay based on some criteria. The convex optimization method solves the power allocation problem in the second sub-problem based on the selection. The simulation results showed that the proposed algorithms are significantly close to the benchmark methods.
WITHDRAWN: Application of molecular image technology in the detection of fungal toxins in rice and identification of their producing bacteria
Authors: Deng Bo , Feng DongSheng , Song YuYin , Zhou YuMen , Wang Ming , Zhu ChunYan , Mei Bo , Han YiYi , Wang Xia , Zhang WeiYi 
Published: May 2023

Abstract
Objective. To explore theoretical basis and feasibility of using computer image processing technology for rapid analysis of rice mold, to promote application of this technology for rice quality analysis, and to make a new exploration for safety of rice in China to realize sustainable development of rice resources in China.
Methods. Four types of rice (Zhengdan 958, Xiangyu 335, Yu'an 13, and Jundan 20) were used as research materials to simulate process of rice mildew in a specific environment (temperature 25°C, humidity 60%). Then, a correlation analysis was performed with amount of bacteria and mycotoxins (aflatoxin B1, vomitoxin, rice gibberellin, ochratoxin) in rice and a discriminant model was established. A BP neural network was used to identify degree of moldiness of rice.
Results. The amount of bacteria in rice samples tended to increase with time, and color of rice grains became darker and duller as mold deepened. On 41st day, sample was seriously deteriorated and experiment could not be conducted. According to amount of bacteria, four rice samples were judged to be normal on days 1-5, pre-mold on days 7-11, mid-mold on days 13-33, and post-mold on days 33. The correlation analysis showed that there was a good correlation between amount of moldy rice and some color characteristics parameters. Y=5020.67-41.661XRt+20.199X1 value, R2=0.934; modeling process of bacterial load of Yu'an 13 introduced color characteristic parameters of B, S, I, modeled as Y=-15602.569+463.54XBn+75209.492Xsm-367.105X1t, R2=0.96; Jundan 20 The modeling process of amount of bacteria carried was introduced with color characteristic parameter I, modeled as Y=2696.205-15.445X1 value, R2=0.823 .