bluuebunny/crossref_metadata_2025_split huggingface dataset:
Superior Adsorption Efficiency of MIL‐101 (Cr) and Nano‐MIL‐101 (Cr) in Anionic and Cationic Dye Removal from Aqueous Solution
Authors: Gökırmak Söğüt Eda 
Published: June 2023

AbstractMetal‐organic frameworks (MOFs) as adsorbent have received considerable attention due to their remarkably high porosity, adjustable pore shape/size, and surface functionality. This study focusses on the adsorption performance and mechanism of two different typological and structural MOFs as superior adsorbents for the efficient removal of anionic and cationic dyes in an aqueous solution. MIL‐101(Cr) and nano‐MIL‐101(Cr) were successfully synthesized by the hydrothermal method using two different protocols and both materials were confirmed by XRD, TG‐DTA‐DTG, FTIR and SEM analyses. The adsorption kinetics and isotherms were determined from the experimental data obtained under optimal conditions. The adsorption kinetics suggests the adsorption process of Congo Red (CR) and Thioflavin T (TFT) onto MIL‐101 (Cr) and nano‐MIL‐101(Cr) conformed to the pseudo‐second‐order kinetic model. The Langmuir isotherm agrees well with the experimental data, and the adsorption capacities for MIL‐101 (Cr) and nano‐MIL‐101 (Cr) were found to be 986 mg g−1 (CR) and 863 mg g−1 (TFT), 1004 mg g−1 (TFT), respectively. The adsorption mechanism is to be related to π–π stacking, hydrogen bonding, pore filling, electrostatic interaction, and partial chemical interaction. This study demonstrates that MIL‐101 (Cr) and nano‐MIL‐101 (Cr) are promising reusable adsorbents with high adsorption capacity for removing dyes from aqueous solutions.
Synthesis, Characterization, In Silico and In Vivo Evaluation of Benzimidazole‐Bearing Quinoline Schiff Bases as New Anticonvulsant Agents
Authors: Shabana Km. , Salahuddin  , Mazumder Avijit , Singh Himanshu , Kumar Rajnish , Tyagi Sonakshi , Datt Vimal , Shankar Sharma Abhishek , Shahar Yar Mohammad , Jawed Ahsan Mohamed , Kumar Yadav Ranjeet 
Published: June 2023

AbstractNitrogen‐containing hybrid heterocyclic compounds have been gaining attention in the field of drug discovery and development due to their diverse pharmacological activities and relatively low toxicity. This study aimed to synthesize a series of new quinoline‐bearing amino acid‐derived benzimidazole derivatives i. e. 3‐{[1‐(1H‐Benzoimidazol‐2‐yl)‐subsituted‐methyl}‐4a,8a‐ dihydro‐1H‐quinoline‐2‐one, and 3‐{[1‐(1H‐Benzoimidazol‐2‐yl)‐substituted‐methyl}‐3H‐ quinoline‐2‐thione. These compounds were synthesized by the condensation of 2‐oxo‐1,2‐dihydro‐quinoline‐3‐ carbaldehyde and 2‐the oxo‐1,2‐dihydro‐quinoline‐3‐carbaldehyde with various substituted 1‐(1H‐benzimidazole‐2‐yl)‐methylamine. After synthesizing the compound, it was subjected to various characterization techniques such as IR, 1HNMR, 13CNMR, and Mass spectroscopy. The synthesized compounds were evaluated for their potential as an anticonvulsant using the subcutaneous Pentylenetetrazol (scPTZ) method, and the results were compared with those obtained for phenytoin and carbamazepine, which were used as standard drugs. Among all the screened derivatives 4 d, 4 e, 5 a, and 5 b were found to be the most potent as compared to conventional drugs (phenytoin and carbamazepine). Also, the molecular docking analysis of the synthesized compounds showed that they share the same mechanism of action as phenytoin and carbamazepine, which involves the inhibition of voltage‐gated sodium channels. Additionally, the analysis revealed that these compounds also inhibit the NMDA receptor. Overall, the development of nitrogen‐containing hybrid heterocyclic compounds has the potential to significantly contribute to the discovery and development of new drugs with improved efficacy, selectivity, and safety profiles.
Lithium Azides Induced SnS Quantum Dots for Ultra‐Fast and Long‐Term Sodium Storage
Authors: Cheng Qiaohuan , Li Yingxue , Gao Panyu , Xia Guanglin , He Shengnan , Yang Yaxiong , Pan Hongge , Yu Xuebin 
Published: June 2023

AbstractTin sulfide (SnS) is an attractive anode for sodium ion batteries (NIBs) because of its high theoretical capacity, while it seriously suffers from the inherently poor conductivity and huge volume variation during the cycling process, leading to inferior lifespan. To intrinsically maximize the sodium storage of SnS, herein, lithium azides (LiN3)‐induced SnS quantum dots (QDs) are first reported using a simple electrospinning strategy, where SnS QDs are uniformly distributed in the carbon fibers. Taking the advantage of LiN3, which can effectively prevent the growth of crystal nuclei during the thermal treatment, the well‐dispersed SnS QDs performs superior Na+ transfer kinetics and pseudocapacitive when used as an anode material for NIBs. The 3D SnS quantum dots embedded uniformly in N‐doped nanofibers (SnS QDs@NCF) electrodes display superior long cycling life‐span (484.6 mAh g−1 after 5800 cycles at 2 A g−1 and 430.9 mAh g−1 after 7880 cycles at 10 A g−1), as well as excellent rate capability (422.3 mAh g−1 at 20 A g−1). This fabrication of transition metal sulfides QDs composites provide a feasible strategy to develop NIBs with long life‐span and superior rate capability to pave its practical implementation.
Groundwater–surface water interaction in Denmark
Authors: Duque Carlos , Nilsson Bertel , Engesgaard Peter 
Published: June 2023

AbstractThe study of groundwater–surface water interaction has attracted growing interest among researchers in recent years due to its wide range of implications from the perspectives of water management, ecology and contamination. Many of the studies shed light on conditions on a local scale only, without exploring a regional angle. To provide a broad and historical overview of groundwater–surface water interaction, a review of research carried out in Denmark was undertaken due to the high density of studies conducted in the country. The extent to which this topic has been investigated is related to Denmark's physiography and climate, the presence of numerous streams and lakes combined with shallow groundwater, and historical, funding, and administrative decisions. Study topics comprise groundwater detection techniques, numerical modeling, and contaminant issues including nutrients, ranging from point studies all the way to studies at national scale. The increase in studies in recent decades corresponds with the need to maintain the good status of groundwater‐dependent ecosystems and protect groundwater resources. This review of three decades of research revealed that problems such as the difference in scales between numerical models and field observations, interdisciplinary research integrating hydrological and biological methods, and the effect of local processes in regional systems remain persistent challenges. Technical progress in the use of unmanned aerial vehicles, distributed temperature sensing, and new cost‐effective methods for detecting groundwater discharge as well as the increasing computing capacity of numerical models emerge as opportunities for dealing with complex natural systems that are subject to modifications in future triggered by climate change.This article is categorized under:
Science of Water > Hydrological Processes
Science of Water > Water and Environmental Change
Water and Life > Nature of Freshwater Ecosystems
Nanostructured bioactive glasses: A bird's eye view on cancer therapy
Authors: Kargozar Saeid , Moghanian Amirhossein , Rashvand Ali , Miri Amir K. , Hamzehlou Sepideh , Baino Francesco , Mozafari Masoud , Wang Andrew Z. 
Published: June 2023

AbstractBioactive glasses (BGs) arewell known for their successful applications in tissue engineering and regenerative medicine. Recent experimental studies have shown their potential usability in oncology, either alone or in combination with other biocompatible materials, such as biopolymers. Direct contact with BG particles has been found to cause toxicity and death in specific cancer cells (bone‐derived neoplastic stromal cells) in vitro. Nanostructured BGs (NBGs) can be doped with anticancer elements, such as gallium, to enhance their toxic effects against tumor cells. However, the molecular mechanisms and intracellular targets for anticancer compositions of NBGs require further clarification. NBGs have been successfully evaluated for use in various well‐established cancer treatment strategies, including cancer hyperthermia, phototherapy, and anticancer drug delivery. Existing results indicate that NBGs not only enhance cancer cell death, but can also participate in the regeneration of lost healthy tissues. However, the application of NBGs in oncology is still in its early stages, and numerous unanswered questions must be addressed. For example, the impact of the composition, biodegradation, size, and morphology of NBGs on their anticancer efficacy should be defined for each type of cancer and treatment strategy. Moreover, it should be more clearly assessed whether NBGs can shrink tumors, slow/stop cancer progression, or cure cancer completely. In this regard, the use of computational studies (in silico methods) is highly recommended to design the most effective glass formulations for cancer therapy approaches and to predict, to some extent, the relevant properties, efficacy, and outcomes.This article is categorized under:
Implantable Materials and Surgical Technologies > Nanomaterials and Implants
Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Linear theory of micropolar media with internal nonlocal potential interactions
Authors: Shorkin Vladimir S. , Vilchevskaya Elena N. , Altenbach Holm 
Published: June 2023

AbstractThis paper proposes a mathematical model that can be used to quantify the effects of a polarized electric field on the mechanical properties of a polar dielectric in the framework of mechanics of deformable solids. The physical essence of the phenomenon is known. However, its direct use in practical calculations may cause difficulties due to the complexity of the composition and structure of materials used in the design and manufacture of specific products whose operation regimes are based on polarization effects. A continuum description of the polarization phenomenon makes it possible to circumvent these difficulties.The basis of the generalized model is a micropolar linearly elastic medium. The generalization consists in taking into account the initial stress state of the material, as well as cross effects under the mutual influence of translational and rotational deformations, the possibility to calculate the characteristics of micropolar material properties based on a special nonlocal model of micropolar media with internal nonlocal potential interactions. It takes into account translational and rotational potential interactions of particles of a continuous medium at finite distances. The kinematic characteristics of the material are the same as those used by the traditional model of a micropolar elastic medium ‐ the gradients of translational displacements of the medium's particles, their rotations independent of the medium's rotation and rotations of the particles relative to the medium. Generalized forces performing work on these generalized displacements are volumetrically and surface‐distributed forces and moments. To determine the values of the parameters of the interparticle potentials of the nonlocal model, a method is proposed using data from experiments to determine the material constants of isotropic linearly elastic materials and the dispersion law for plane acoustic waves of high frequency. The paper considers and quantifies the effects of anisotropy in an initially isotropic material, as well as anharmonic effects that cause dielectric heating by a periodically changing polarizing field. The results are compared qualitatively and quantitatively with known experimental data and physical notions of the phenomena in question.
Simulation of Thermoelastic Behavior of Technical Systems with Relatively Moving Parts - Modeling Process, Part Coupling Approaches and Application to Machine Tools
Authors: Sauerzapf Stefan , Beitelschmidt Michael 
Published: June 2023

AbstractModels of technical systems play an essential role from the conceptual phase to the end of life of the system, as they allow the prediction of the behavior of the real world instance by simulation. Time and money spent on building prototypes can be saved, and the development process can be significantly accelerated. Furthermore, simulations allow the optimization of systems in advance.A major problem in modeling modern systems is complexity, as machines increasingly include components from different areas such as cooling systems, active bearings, etc., along with the control units that govern the interaction. The model must incorporate all these systems and reflect their behavior with sufficient accuracy. This results in the need to modularize the modeling process and create a model from all these sub-modules.Within the framework of the Collaborative Research Center/TR96 (CRC/TR96), a methodology has been developed to solve the above problems. It enables the coupling of several sub-models to a complex system model. The methodology is described together with the open-source and proprietary tools used to facilitate all necessary modeling and simulation steps.As an example of the application of the described methodology, the modeling and simulation of a complete machine tool is presented. Special attention is given to the modeling of the moving part contacts, since they have a significant influence on the simulation result. Different approaches for contact modeling are compared.Finally, the next steps for transferring the developed methodology to practical applications are outlined.
Determination of the Thermal Properties of Pre-stressed Fiber-Reinforced Polymer Concrete
Authors: Engert Michelle , Werkle Kim Torben , Möhring Hans-Christian 
Published: June 2023

AbstractWith its low thermal conductivity and high thermal capacity, polymer concrete has excellent thermal properties that when used in machine tools ensure increased accuracy of the manufactured parts. Polymer concrete has been used successfully in machine tool construction for many years in the form of machine beds. The aforementioned thermal properties in combination with a low density, high damping and a lower primary energy requirement also make polymer concrete interesting for use as a structural component. However, the comparatively low tensile strength and creep tendency of the material pose a challenge here. One approach to increase the tensile strength of the material is the integration of prestressed carbon fibres into the material. In order to clarify the suitability of this hybrid material, its temperature behaviour is investigated in this paper. The focus is on the investigation of residual stresses that arise during heating, which result from the combination of the positive thermal expansion coefficient of polymer concrete with the negative thermal expansion coefficient of the carbon fibres. In addition, the flexural properties of pure polymer concrete and of pre-stressed fibre-reinforced polymer concrete are determined at different test temperatures within the scope of this paper. It is shown that the prestressing of fiber-reinforced polymer concrete leads to an improvement of the flexural strength and the stiffness of polymer concrete.
Lebensbedrohliche Intoxikation einer Adoleszenten mit Antidepressiva aus dem Hausmüll
Authors: Elsayed K. , Castillo L. M. , Steindl D. , Endmann M. 
Published: June 2023

ZusammenfassungEin knapp 16-jähriges Mädchen wurde vom Rettungsdienst komatös in die Kinderklinik gebracht. Nach umfangreicher Diagnostik konnte die Diagnose einer (in der Literatur als letal beschriebenen) Intoxikation mit Amitriptylin gestellt werden. Die Jugendliche leugnete die Einnahme zunächst vehement. Die Eltern hatten erst nach Androhung staatsanwaltschaftlicher Ermittlungen angegeben, dass sie kürzlich mehrere und verschiedene Schachteln Tabletten wegen abgelaufenen Verfallsdatums resp. zu vieler Nebenwirkungen in der Mülltonne entsorgt hatten. Die Patientin hatte sich ihrer bemächtigt und nach einem Streit mit ihrer Mutter eine große Menge der Tabletten zu ihrer eigenen Beruhigung eingenommen.
Time interval between the onset of connective tissue disease symptoms and first contact with a rheumatologist: results from the German National Database of collaborative arthritis centers
Authors: Kernder Anna , Thiele Katja , Chehab Gamal , Schneider Matthias , Callhoff Johanna 
Published: June 2023

AbstractThe long-term outcome of connective tissue diseases is associated with the time from symptom onset to diagnosis. To understand gaps in care, we determine whether the length of time between symptom onset and first presentation to a rheumatologist has changed in Germany in recent decades. We analyzed data on patients diagnosed with connective tissue diseases (n = 19,662) collected from the German National Database of the Regional Cooperative Rheumatology Centers. We reviewed the onset of relevant symptoms listed at first presentations from 1993 to 2018 and performed a quantitative analysis of the intervals until first presentation to a rheumatologist. We compared time intervals and performed a linear mixed regression model with random effects to identify associated factors. Although the interval between the onset of symptoms and first presentation to a rheumatologist has diminished since 1980 for all connective tissue diseases, there has been no relevant improvement during the past 2 decades. The interval between symptoms and presentation increases with patients age for all connective tissue diseases (e.g., Systemic sclerosis; for each 10-year-increment of patients age: β 0.41, CI 0.38; 0.44). Among those diagnosed with systemic sclerosis, the mean interval was 1.5 years (95% CI 1.1; 1.8) for male patients and 2.6 years (95% CI 2.4; 2.8) for females. Patients presenting with different degrees of disease severity on their first visits and with different educational levels had similar mean intervals between symptoms and first presentation regardless of their final diagnoses. Over the past 2 decades, the time to first consultation with a rheumatologist has not continued to improve in Germany, but has stagnated at the same level. Selected patient subgroups, such as older patients with suspected connective tissue diseases and female patients with suspected systemic sclerosis, are at risk to present late and may in particular benefit from an earlier referral to a rheumatologist.
Paediatric pineal region cysts: enigma or impaired neurofluid system?
Authors: Ludwig Hans C. , Dreha-Kulaczewski Steffi , Bock Hans Christoph 
Published: June 2023

Abstract

Purpose
Pineal region cysts (PCs) may affect the tectum and aqueduct and cause deep central vein congestion. Beside headaches, PC often causes a broad range of symptoms, leading to prolonged diagnosis and therapy. The aims of this study are to reveal parameters that might explain the ambiguity of the symptoms and to identify factors in association with the respiration-driven neurofluid system.

Methods
This retrospective study included 28 paediatric patients (mean age 11.6 years) who received surgical treatment and 18 patients (mean age 11.3 years) who were followed conservatively. Symptoms, time to diagnosis, cyst size, ventricular indices, head circumference and postoperative outcome, were analysed. Four patients were investigated for CSF dynamics with real-time MRI. The mean follow-up time was 1.6 years.

Results
The most common early onset symptoms were headaches (92%), blurred vision (42.8%), sleep disturbances (39.3%) and vertigo (32.1%). Tectum contact was observed in 82% of patients, and MRI examinations revealed that imaging flow void signals were absent in 32.1% of patients. The maximal cyst diameters were 13.7 × 15.6 mm (mean). Together with a postoperative flow void signal, 4 patients recovered their respiration-driven CSF aqueductal upward flow, which was not detectable preoperatively. After surgery the main symptoms improved.

Conclusion
Despite proximity to the aqueduct with frequently absent flow void signals, hydrocephalus was never detected. Data from real-time MRI depicted a reduced preoperative filling of the ventricular CSF compartments, indicating a diminished fluid preload, which recovered postoperatively.
Mental body representations of women with tattoos in emerging adulthood — a cluster analysis
Authors: Jabłońska Klaudia , Mirucka Beata 
Published: June 2023

AbstractTattoo is a permanent body modification relevant to women’s bodily experiences. Previous studies on the population of tattooers have focused mainly on searching for negative or positive aspects of tattooing, mainly in the field of self-esteem. The aim of this study was to explore the mental body representations of tattooed women during emerging adulthood. Three hundred and twenty-seven women with tattoos, aged 18 to 25 (M = 21.48; SD = 2.05), participated in the study. In the study, we adopted a quantitative research project; the data for analysis was obtained from questionnaires that were completed online between January and March 2021. Women with tattoos completed a survey containing demographic questions, questions regarding their tattoos, the Battery of Tests of Body Self Representations, and the Rosenberg Self-Esteem Scale. Based on that a cluster analysis, we have discovered three types of mental body representations that may characterize them: (1) unstable, (2) disordered, and (3) integrated. The study showed that having a tattoo is associated with experiencing carnality in a specific way.
The kinetics of SARS-CoV-2 viremia in COVID-19 patients receiving remdesivir
Authors: Krifors Anders , Karlsson Linda , Ekman Martin , Lorant Camilla , Skorup Paul 
Published: June 2023

AbstractDetection of SARS-CoV-2 RNA in serum, viremia, has been linked to disease severity and outcome. The kinetics of viremia in patients receiving remdesivir has not been thoroughly studied and could help predict treatment response and outcome. We investigated the kinetics of SARS-CoV-2 viremia and factors associated with baseline viremia, viral clearance and 30-day mortality in patients receiving remdesivir. An observational study including 378 hospitalised patients (median age 67 years, 67% male) sampled with serum SARS-CoV-2 RT-PCR within ± 24 h of initiation of remdesivir treatment. Baseline viremia was present in 206 (54%) patients with a median Ct value of 35.3 (IQR = 33.3–37.1). In patients with baseline viremia, the estimated probability of viral clearance was 72% by day 5. Ct values decreased significantly during remdesivir treatment for viremic patients, indicating an increase in viral load. In total, 44 patients (12%) died within 30 days, and mortality was significantly associated with viremia at baseline (OR = 2.45, p = 0.01) and lack of viral clearance by day 5 (OR = 4.8, p =  < 0.01). Viral clearance was not associated with any individual risk factor. Viremia appears to be a prognostic marker before and during remedesivir treatment. The resolution of viremia was similar to patients not receiving remdesivir in other studies, and the decrease in Ct values during treatment questions the antiviral capacity of remdesivir in vivo. Prospective studies are warranted to confirm our findings.