bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orientated-quantitative computed tomography study on individualized axial safety target area of femoral neck screw channel and establishment of a stable spatial coordinate system based on anterior cortex of femoral neck basilar
Authors: Deng Ying-Sheng , Jiang Guang-Liang , Cao Yu-Fang , Deng Hong-Yi , Yang Hong-Ping , Zhu Zhen-Biao , Wu Duo-Qing , Wang Qiu-Gen 
Published: April 2023

Background:
Frequent in-out-in femoral neck screws were reported potential huge iatrogenic-injury risks, related to axial safe target area (ASTA) of femoral neck screws channel. However, orientated-quantitative ASTA based on stable coordinate system was unreported before.

Methods:
Three-dimensional reconstruction was performed on computed tomography (CT) images of 139 intact normal hips, and the intersection area, defined as ASTA, was obtained by superimposing the axial CT images of each femoral neck. Taking anterior cortex of femoral neck basilar (AC-FNB) as landmark, a coordinate system was established to measure the anterior–posterior diameter (D-AP), the superior–inferior diameter (D-SI) and the oblique angle respectively. Each intersection was overlaid up to the axial CT images to determine the coronal location of the ASTA boundaries.

Results:
Each ASTA presented an inclined rounded triangle with a flat anterior base coincided with AC-FNB. There were significant sex differences in D-SI (male: 33.6±2.3 vs. female: 29.4±1.9 mm) and D-AP (male: 25.3±2.1 vs. 21.9±1.9 mm), P<0.001. D-SI was found to be positively correlated with D-AP (R
2=0.6). All fluoroscopic visible border isthmus completely matched the corresponding ASTA boundaries. The oblique angle was 5–53° (male: 28.1±10.3°, female: 27.1±8.2°) without significant difference between sexes.

Conclusion:
The intersection method was employed to conveniently acquire orientated-quantitative individualized ASTA. Under this coordinate system, x-ray data of screws could be converted to axial coordinates in CT ASTA, which could help surgeons design combined screws configuration preoperatively and evaluate quantitatively their axial position intraoperatively.
Dietary carbohydrates in the management of epilepsy
Authors: Haridas Babitha 
Published: April 2023

Purpose of review
The role of dietary carbohydrates in the management of epilepsy is intrinsically linked to the ketogenic diet. The ketogenic diet has been in use for well over a century now. There have been numerous adaptations to the diet. It is crucial to understand the indications and role of the ketogenic diet in the management of epilepsy.

Recent findings
There have been new studies that have looked at the role of ketogenic ratios in seizure control. In addition, there has been new evidence in the role of using the ketogenic diet therapy instead of antiseizure medications. These data highlight that the ketogenic diet should be tailored for patients and caregivers. When used appropriately, it can result in a significant improvement in seizure control as well as cognitive and developmental gains.

Summary
The ketogenic diet therapy has undergone numerous revisions and reiterations from its initial reported use in patients a century ago. This has enabled us to tailor the diet specific to each patient's underlying diagnosis.
The analgesic efficacy of pregabalin versus placebo for septorhinoplasty: A meta-analysis
Authors: Liang Zanmei , Xu Yang , Xue Zhihui 
Published: April 2023

Background:
The analgesic efficacy of pregabalin supplementation for septorhinoplasty remains elusive. This meta-analysis was conducted to compare pregabalin supplementation with placebo for the postoperative pain control of septorhinoplasty.

Methods:
We systematically searched several databases including PubMed, EMbase, Web of Science, EBSCO and Cochrane library databases, and included randomized controlled trials (RCTs) regarding the effect of pregabalin supplementation versus placebo for pain control after septorhinoplasty. This meta-analysis was conducted by fixed or random-effect model based on the heterogeneity.

Results:
Seven RCTs were included in this meta-analysis. In comparison with control group for septorhinoplasty, pregabalin supplementation was associated with significantly decreased pain scores at 1 h (standard mean difference [SMD] = −1.45; 95% confidence interval [CI] = −2.43 to −0.47; P = .004), pain scores at 2 hours (SMD = −1.01; 95% CI = −1.83 to −0.20; P = .02), pain scores at 6 hours (SMD = −1.00; 95% CI = −1.47 to −0.54; P < .0001), number of rescue analgesics (odd ratio [OR] = 0.18; 95% CI = 0.08–0.39; P < .0001) and analgesic consumption (SMD = −2.78; 95% CI = −5.05 to −0.51; P = .02), but unraveled no obvious impact on the incidence of nausea and vomiting (OR = 0.55; 95% CI = 0.24–1.27; P = .16).

Conclusions:
Pregabalin supplementation was effective to improve pain relief after septorhinoplasty.
Chaihu Longgu Muli Decoction for post-stroke insomnia: A protocol for systematic review and meta-analysis
Authors: Huang Xuedi , Xiong Yue , Jiang Sichen , Tang Lihua , Lin Xingzhen , Fang Xinyue , Shi Yuzhen , Lan Wanning , Xie Yaying , Peng Tianzhong 
Published: April 2023

Background:
Poststroke insomnia (PSI) is a frequent complication of stroke usually as a comorbidity of poststroke depression and mainly occurs within the first 6 months after stroke.[1] Addressing PSI to improve stroke prognosis is of great value. Herbal medicine like Chaihu Longgu Muli Decoction (CLMD), which is commonly considered to be a good treatment for depression and epilepsy, has the therapeutic potential on PSI; however, insufficient systematic reviews were conducted to testify its efficacy. Therefore, the objective of this paper is to provide reliable evidence of the efficacy and safety of CLMD on PSI and a foundation for further investigation.

Methods:
The literature of clinical randomized controlled trials (RCTs) regarding CLMD for PSI published before June of 2021 will be retrieved in the databases, and 2 investigators will be asked to collect and crosscheck the data independently. For the including studies, the quality evaluation on methodology will be assessed in the light of the Cochrane Handbook for Systematic Review of Interventions V.5.1.0 as well as the quality of evidence will be evaluated by the Grading of Recommendations Assessment, Development, and Evaluation. Besides, the assessment of heterogeneity and reporting bias, the sensitivity analysis and the subgroup analysis will be conducted. Stata 15 will be applied to analyze the above data.

Results:
The review will conduct a high-quality synthesis on present evidence of CLMD for PSI.

Conclusion:
The conclusion of the study will indicate whether CLMD is effective and safe for PSI.
Intervention for job burnout reduction among a sample of Nigerian lecturers
Authors: Eseadi Chiedu , Ardi Zadrian , Victor-Aigbodion Vera , Ndille Roland , Obasuyi Hero Usiomoefo , Ogbuabor Shulamite Ebere 
Published: April 2023

Background:One of the major issues facing Nigerian university lecturers is job burnout. In the current study, Nigerian university history lecturers were examined in respect of job burnout prior to and after an online psychological intervention that followed the rational emotive behavior therapy (REBT) principles and practice.Methods:In this study, a group randomized controlled trial approach was used, and only 80 university history lecturers with high burnout levels were included. We had 40 history lecturers participating in an online intervention group and 40 history lecturers participating in the control group. A questionnaire – Oldenburg Burnout Inventory – was used to collect data about job burnout.Results:After the history lecturers underwent the online psychological intervention (online REBT), significant reductions in mean job burnout were recorded (F(1, 78) = 5756.11;P < .001). Findings show a statistically significant effects of time on burnout scores of history lecturers [F(2156) = 1323.69,P < .001, ω2 = 0.92]. There was also a significant group and time interaction effect on the participants’ burnout scores [F(2156) = 1323.69,P < .001, ω2 = 0.91].Conclusion:University history lecturers can benefit from online psychological intervention that targets job burnout reduction. The current study paves way for future studies to validate the efficacy of online REBT intervention among other employees who struggle with burnout problem.
Application of low molecular weight heparins in umbilical artery thrombosis: A case series and review of the literature
Authors: Wang Ting , Yao Yingsha , Xu Ting , Wang Wenshan , Zhou Yimin , He Jing , Jiang Ruoan 
Published: April 2023

Rationale:
Low molecular weight heparins are widely used in various thrombotic diseases and exert a preventive effect on thrombosis in high-risk patients. Umbilical artery thrombosis (UAT) is a rare occurrence that is difficult to detect during routine prenatal visits but can lead to adverse perinatal outcomes.

Patient concerns:
The aim of this study was to elucidate the therapeutic effect of low molecular weight heparins on UAT and to provide a new treatment option for the timing of delivery timing.

Diagnoses and interventions:
A retrospective study was conducted on cases involving thrombosis of the umbilical cord enrolled from July 2017 to July 2022. Data were acquired and analyzed from medical records and the final diagnosis was confirmed by histopathology. All included patients received LWMHs therapy after initial diagnosis of UAT.

Outcomes:
The mean age of the 10 pregnant women recruited into this study was 27.9 ± 4.0 year-of-age; 1 (10%) was elderly. The gestational age at diagnosis was 29.9 ± 3.7 weeks, the gestational age at termination was 36.3 ± 2.5 weeks and the mean gestational age of extension was 6.4 ± 4.2 weeks. Low molecular weight heparin sodium was administered after umbilical artery embolism was detected on ultrasound. The LWMHs treatment received by the included patients in this study was subcutaneous injection. The specific usage varies due to the types of LWMHs. Of the 10 cases, 5 (50%) had fetal distress but all fetuses were born alive without neonatal asphyxia. With regards to delivery mode, 9 pregnancies were terminated by cesarean section.

Lesson:
Early anticoagulant treatment with LWMHs may improve pregnancy outcomes. The timing and mode of termination of pregnancy should be determined according to the condition of the mother and the fetus along with the gestational age.
A comparison of the effects of connective tissue massage and classical massage on chronic mechanical low back pain
Authors: Er Göktuğ , Yüksel İnci 
Published: April 2023

Background:
The study aimed to compare the effects of connective tissue massage (CTM) and classical massage (CM) in patients with chronic mechanical low back pain on pain and autonomic responses and to determine the most effective manual therapy method.

Methods:
Seventy individuals with chronic mechanical low back pain were randomly divided into CTM (n = 35) and CM (n = 35) groups. The participants were given a 4-week treatment protocol consisting of a hot pack, exercise, and CTM or CM for 20 sessions. A visual analog scale was used to measure pain intensity. Heart rate, blood pressure, and skin temperature were measured for the evaluation of autonomic responses. In addition, disability (Oswestry disability index), quality of life (short form 36), and sleep quality (Pittsburgh sleep quality index) were evaluated. Participants were assessed before and after the 4-week treatment period as well as at the end of the 6-week follow-up period. In addition, visual analog index measurements were repeated at the end of each treatment week.

Results:
Pain intensity was decreased in both groups (P < .05). However, CM was more effective than CTM at the end of the 2nd week (P < .05). In autonomic responses results, there were increases in peripheral skin temperatures in both groups (P < .05). Disability, quality of life, and sleep quality improved in both groups (P < .05). There were no differences between the groups relating to autonomic responses, disability, quality of life, and sleep quality (P > .05).

Conclusion:
The results of this study showed that massages were similar effect. The fact that CM is a frequently used technique in pain management and is as effective as CTM in autonomic responses will make it more preferred in the clinic.
Efficacy and safety of Jinhua Qinggan granules in the treatment of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis
Authors: Si Xiuying , Ma Xiaoxue , Wang Youpeng , Li Yongjun , Liu Lujia , Yang Yang , Guo Zheng , Liang Yuan , Pan Guangxia 
Published: April 2023

Objective:
To evaluate, using meta-analysis, the efficacy and safety profile of Jinhua Qinggan granules (JHQG) in the treatment of novel coronavirus pneumonia.

Methods:
We screened multiple publication databases (PubMed, Embase, The Cochrane Library, Web of Science, CNKI, WanFang, and VIP), using parameters designed to identify articles detailing randomized controlled trials relating to the treatment of novel coronavirus pneumonia with JHQG. The inclusion period for each search was the point of database inception to November 2022. Each piece of literature identified in our initial screening was independently reviewed by 2 researchers, who extracted the relevant data and evaluated the bias risk associated with the study. The data was split in 2: the control group (containing patients who had received routine treatment or placebo) and the experimental group (containing patients treated with JHQG). The meta-analysis was performed using Revman 5.4 software. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation approach.

Results:
Four articles were selected for this study and combined included a total of 582 patients, which were subdivided into experimental (n = 347) and control (n = 235) groups. The results showed that treatment with JHQG could significantly: enhance the improvement rate of primary symptoms [relative ratio (RR) = 1.26,95% confidence interval (CI) (1.07, 1.49), P = .007] and fever [RR = 1.48, 95% CI (1.07, 2.04), P = .02]; decrease the viral nucleic acid in patients with coronavirus disease 2019 (COVID-19) [RR = 2.04, 95% CI (1.15, 3.62), P = .02] and reduce the progression of pneumonia [RR = 0.34, 95% CI (0.17, 0.67), P = .002]. However, there was no significant difference between the 2 groups with regards to: the improvement rate of cough, nausea and vomiting, fatigue, computed tomography, or frequency of adverse reactions.

Conclusions:
Current evidence indicates that JHQG is effective in treating COVID-19, increasing the rate of improvement for fever, increasing the negative rate of viral nucleic acid in patients with COVID-19 and reducing the aggravation rate of pneumonia. These conclusions need to be verified by further rigorous studies, as the existing results were limited by the number and quality of the included studies.
Prognostic value of lymphovascular space invasion in stage IA to IIB cervical cancer: A meta-analysis
Authors: Huang Yuan , Wen Weibo , Li Xiangdan , Xu Dongyuan , Liu Lan 
Published: April 2023

Background:
Lymphovascular space invasion (LVSI) is a prognostic factor in the existing TNM classification system. The present meta-analysis assessed the role of LVSI in predicting the prognosis of stage IA to IIB cervical cancer (CC).

Materials and methods:
PubMed, EMBASE, and Cochrane Library electronic databases were searched to determine relevant articles published in the English language. Our search deadline was May 2022. Critical Appraisal of Prognostic Studies was used to assess the quality for each article. Pooled hazard ratios (HRs) were used to evaluate the performance of LVSI in prognosis prediction.

Results:
We enrolled 8 studies involving 25,352 patients published after 2010. Thus, high LVSI was an unfavorable factor in predicting overall survival (HR, 2.08; 95% confidence interval, 1.63–2.66; P = .006) and disease-free survival (HR, 2.20; 95% confidence interval, 1.79–2.70; P = .000) for patients with CC. However, the disease-free survival and overall survival were significantly different on univariate analysis based on the subgroup analysis stratified by analysis method, but no obvious heterogeneity was found across diverse articles.

Conclusions:
The present study showed that LVSI predicts the poor prognostic outcome of stage IA to IIB CC. However, well-designed clinical articles should further assess the independent prognosis prediction performance of LVSI in CC.
Climate change impacts on children's respiratory health
Authors: Kline Olivia , Prunicki Mary 
Published: April 2023

Purpose of review
This review examines the impact of climate change on the respiratory health of children, with a focus on temperature, humidity, air pollution, and extreme weather events. Climate change is considered the greatest health threat of our time, and children are especially at risk. This review is timely and relevant as it provides an overview of the current literature on the effects of climate change on children's respiratory health, and the implications of these findings for clinical practice and research.

Recent findings
The findings of this review suggest that climate change has a significant impact on children's respiratory health, with temperature, humidity, air pollution, and extreme weather events being key contributory factors. Increases in extreme weather events such as heatwaves, wildfires, floods, droughts, hurricanes and dust storms all cause the health of children's respiratory system to be at increased risk.

Summary
The findings of this review suggest that climate change has a significant impact on children's respiratory health, and that mitigation and adaptation strategies are necessary to protect children from the harmful effects of climate change and improve their respiratory health. Overall, a comprehensive and integrated approach is necessary to protect children from the increasing impacts of climate change.
Exercise Preferences, Barriers, and Facilitators of Individuals With Cancer Undergoing Chemotherapy Before Stem Cell Transplantation
Authors: Purdy Graeme M. , Nanad Rianna , Ternes Leslie , Dolgoy Naomi D. , Sellar Christopher M. , Francis George , Crisp Nicole , Pituskin Edith , de Guzman Wilding Marie , Perry Sarah , Sandhu Irwindeep , Venner Christopher P. , McNeely Margaret L. 
Published: April 2023

Background
Exercise can help mitigate side effects of hematopoietic stem cell transplantation (HSCT), particularly when initiated before HSCT. However, the exercise-related barriers, facilitators, and preferences of this population remain unclear.

Objective
This study aimed to explore the patient experience to inform future implementation of a prehabilitation intervention.

Interventions/Methods
A 2-phase sequential explanatory mixed-methods study was conducted using (1) cross-sectional survey and (2) focus groups. Survey questions aligned with the Theoretical Domains Framework. Focus group data were analyzed using a directed content analysis approach, followed by inductive thematic analysis to generate themes that represented the exercise-related barriers, facilitators, and preferences of participants.

Results
Twenty-six participants completed phase 1 (n = 22 with multiple myeloma). Fifty percent of participants (n = 13) were fairly/very confident in their ability to exercise pre-HSCT. Eleven participants completed phase 2. Exercise barriers included knowledge/skill limitations, inadequate healthcare provider support, and the emotional toll of treatment. Facilitators included social support and goals. Exercise preferences were related to 2 themes: (1) program structure (subthemes: prescription and scheduling, mode of delivery) and (2) support (subthemes: support from personnel, tailoring, and education).

Conclusion
Key exercise-related barriers included knowledge limitations, disease/treatment effects, and inadequate support. Prehabilitation should be tailored, flexible, and include education and a virtual or hybrid delivery model in this population.

Implications for Practice
Nurses are well positioned to identify functional limitations and counsel and refer patients to exercise programming and/or physiotherapy services. Including an exercise professional in the pretransplant care team would provide key supportive care assistance for the nursing team.
Rounding and Quick Access Education to Reduce Catheter-Associated Urinary Tract Infections
Authors: Garcia Danielle M. , Makic Mary Beth Flynn , Casey Kathy 
Published: April 2023

Purpose/Objectives
The acute care division of a tertiary medical center experienced a 167% increase in catheter-associated urinary tract infections, with 2 inpatient surgical units accounting for 67% of infections. A quality improvement project was implemented to address the infection rates on the 2 inpatient surgical units. The aim was to reduce catheter-associated urinary tract infection rates by 75% in the acute care inpatient surgical units.

Description of the Project/Program
A survey identified educational needs of staff, with response data informing the development of a quick response code containing resources for prevention of catheter-associated urinary tract infections. Champions rounded on patients and audited maintenance bundle adherence. Educational handouts were disseminated to increase compliance with bundle interventions. Outcome and process measures were tracked on a monthly basis.

Outcome
Infection rates decreased from 1.29 to 0.64 per 1000 indwelling urinary catheter days, catheter utilization increased 14%, and maintenance bundle compliance was 67%.

Conclusion
The project enhanced quality care through the standardization of preventive practices and education. The data reflect a positive effect on catheter-associated urinary tract infection rates from increased awareness of the nurse's role in the prevention process.
Hospital-Based Credentialing and Privileging
Authors: Dresser Susan C. , Elgin Kimberly W. 
Published: April 2023

Purpose/Objectives
The purpose of this article is to provide an overview of hospital-based credentialing and privileging processes for clinical nurse specialists (CNSs), describe barriers to success, and share lessons learned from CNSs who have successfully navigated the credentialing and privileging process.

Description of Project
This article shares knowledge, experiences, and lessons learned from an initiative to achieve hospital credentialing and privileging for CNSs at 1 academic medical center.

Outcome
Policies and procedures for credentialing and privileging CNSs are now consistent with other advanced practice providers.