bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increasing beam stability zone in synchrotron light sources using polynomial quasi-invariants
Authors: Sánchez Edgar Andrés , Flores Alain , Hernández-Cobos Jorge , Moreno Matías , Antillón Armando 
Published: January 2023

AbstractThe objective of this article is to propose a scheme to increase the stability zone of a charged particles beam in synchrotrons using a suitable objective function that, when optimized, inhibits the resonances onset in phase space and the dynamic aperture of electrons in storage rings can be improved. The proposed technique is implemented by constructing a quasi-invariant in a neighborhood of the origin of the phase space, then, by using symbolic computation software, sets of coupled differential equations for functions involved in nonlinear dynamics are obtained and solved numerically with periodic boundary conditions. The objective function is constructed by proposing that the innermost momentum solution branch of the polynomial quasi-invariant approaches to the corresponding ellipse of the linear dynamics. The objective function is optimized using a genetic algorithm, allowing the dynamic aperture to be increased. The quality of results obtained with this scheme are compared with particle tracking simulations performed with available software in the field, showing good agreement. The scheme is applied to a synchrotron light source model that can be classified as third generation due to its emittance.
A novel neural network model of Earth’s topside ionosphere
Authors: Smirnov Artem , Shprits Yuri , Prol Fabricio , Lühr Hermann , Berrendorf Max , Zhelavskaya Irina , Xiong Chao 
Published: January 2023

AbstractThe Earth’s ionosphere affects the propagation of signals from the Global Navigation Satellite Systems (GNSS). Due to the non-uniform coverage of available observations and complicated dynamics of the region, developing accurate models of the ionosphere has been a long-standing challenge. Here, we present a Neural network-based model of Electron density in the Topside ionosphere (NET), which is constructed using 19 years of GNSS radio occultation data. The NET model is tested against in situ measurements from several missions and shows excellent agreement with the observations, outperforming the state-of-the-art International Reference Ionosphere (IRI) model by up to an order of magnitude, especially at 100-200 km above the F2-layer peak. This study provides a paradigm shift in ionospheric research, by demonstrating that ionospheric densities can be reconstructed with very high fidelity. The NET model depicts the effects of numerous physical processes governing the topside dynamics and can have wide applications in ionospheric research.
Identification of a human estrogen receptor α tetrapeptidic fragment with dual antiproliferative and anti-nociceptive action
Authors: Jouffre Baptiste , Acramel Alexandre , Belnou Mathilde , Santolla Maria Francesca , Talia Marianna , Lappano Rosamaria , Nemati Fariba , Decaudin Didier , Khemtemourian Lucie , Liu Wang-Qing , Maggiolini Marcello , Eschalier Alain , Mallet Christophe , Jacquot Yves 
Published: January 2023

AbstractThe synthetic peptide ERα17p (sequence: PLMIKRSKKNSLALSLT), which corresponds to the 295–311 region of the human estrogen receptor α (ERα), induces apoptosis in breast cancer cells. In mice and at low doses, it promotes not only the decrease of the size of xenografted triple-negative human breast tumors, but also anti-inflammatory and anti-nociceptive effects. Recently, we have shown that these effects were due to its interaction with the seven-transmembrane G protein-coupled estrogen receptor GPER. Following modeling studies, the C-terminus of this peptide (sequence: NSLALSLT) remains compacted at the entrance of the GPER ligand-binding pocket, whereas its N-terminus (sequence: PLMI) engulfs in the depth of the same pocket. Thus, we have hypothesized that the PLMI motif could support the pharmacological actions of ERα17p. Here, we show that the PLMI peptide is, indeed, responsible for the GPER-dependent antiproliferative and anti-nociceptive effects of ERα17p. By using different biophysical approaches, we demonstrate that the NSLALSLT part of ERα17p is responsible for aggregation. Overall, the tetrapeptide PLMI, which supports the action of the parent peptide ERα17p, should be considered as a hit for the synthesis of new GPER modulators with dual antiproliferative and anti-nociceptive actions. This study highlights also the interest to modulate GPER for the control of pain.
Fretting wear behavior of Inconel 718 alloy manufactured by DED and treated by UNSM
Authors: Li Chao , Karimbaev Ruslan , Wang Shengjie , Amanov Auezhan , Wang Dagang , Abdel Wahab Magd 
Published: January 2023

AbstractAlloy 718 is commonly used in the maritime and aerospace industries due to its strength and durability, particularly in engine rotating components such as disks, fan blades, and high-pressure compressors. As a new type of 3D printing technology, directed energy deposition (DED) can employ lasers to melt metal powders or wires to fabricate arbitrary-shaped workpieces directly from customized data, thereby making machining more synergistic and intuitive. However, the surface properties of the DED-printed alloy 718 samples, such as surface roughness and wear resistance, are typically subpar. By introducing severe plastic deformation to the near-surface, ultrasonic nanocrystal surface modification (UNSM) can be used as a post-processing method and results in altered properties. The uniaxial tensile test reveals that the UNSM-treated alloy 718 exhibits a higher mechanical property. Moreover, using a fretting test rig in accordance with the cylinder-on-plane agreement, a higher wear resistance for UNSM-treated alloy 718 is observed. This study employs the finite element method to fully comprehend the effect of UNSM on wear performance. The fretting wear process of Inconel 718 alloy is established using an energy-based finite element model. Considering the severe practical scenarios, the Johnson–Cook constitutive model is implemented, with the linear isotropic hardening model capturing the plastic behavior. In comparison to experimental measurements, the finite element results demonstrate unprecedented wear loss consistency with an error of less than 2%. Therefore, we conclude that the finite element model built in this study exhibits a high accuracy and can be used to analyze the effect of UNSM on fretting wear behavior. According to finite element analysis, as the normal load increases, the improvement in wear resistance induced by UNSM decreases. Given that the finite element model is based on the energy method, the effects of coefficient of friction (COF) and wear coefficient modified by UNSM are investigated separately. According to the findings, the UNSM-modified COF and wear coefficient play a significant role in determining the wear characteristics. Due to the removal of a substantial amount of material from the central area of the alloy 718 surface by wear, it is also possible to observe that severe plastic strains are primarily concentrated at the edges of the wear scars.
Pulse and pulsating supercharging phenomena in a semi-enclosed pipe
Authors: Wang Fei , Li Heng 
Published: January 2023

AbstractConsidering the discontinuous square pulse wave and continuous sine pulsating wave, we report a distinctive supercharging phenomenon of fluid in a water-filled semi-enclosed pipe and reveal the supercharging regularity. We demonstrate that there can be significant supercharging phenomena at the pipe end-face if the water is periodically injected at the pipe inlet with certain frequency. Compared to the traditional pulsating injection method, the present injection strategy can remarkably enhance the peak pressure of the water at the end face of the pipe. We explained this phenomenon by numerical simulations based on the computational fluid dynamic method. It’s found that there is a quantitative relationship between the optimal pulse frequency, pipe length and wave speed. The proposed frequency model is suitable for the multi-waveform, such as sine wave, square wave and arcuate wave. The fluid pressure at the pipe end-face intermittently increases and the end-face peak pressure is largest when the inlet injection frequency equals to the optimal frequency.
Muscle coordination and recruitment during squat assistance using a robotic ankle–foot exoskeleton
Authors: Jeong Hyeongkeun , Haghighat Parian , Kantharaju Prakyath , Jacobson Michael , Jeong Heejin , Kim Myunghee 
Published: January 2023

AbstractSquatting is an intensive activity routinely performed in the workplace to lift and lower loads. The effort to perform a squat can decrease using an exoskeleton that considers individual worker’s differences and assists them with a customized solution, namely, personalized assistance. Designing such an exoskeleton could be improved by understanding how the user’s muscle activity changes when assistance is provided. This study investigated the change in the muscle recruitment and activation pattern when personalized assistance was provided. The personalized assistance was provided by an ankle–foot exoskeleton during squatting and we compared its effect with that of the no-device and unpowered exoskeleton conditions using previously collected data. We identified four main muscle recruitment strategies across ten participants. One of the strategies mainly used quadriceps muscles, and the activation level corresponding to the strategy was reduced under exoskeleton assistance compared to the no-device and unpowered conditions. These quadriceps dominant synergy and rectus femoris activations showed reasonable correlations (r = 0.65, 0.59) to the metabolic cost of squatting. These results indicate that the assistance helped reduce quadriceps activation, and thus, the metabolic cost of squatting. These outcomes suggest that the muscle recruitment and activation patterns could be used to design an exoskeleton and training methods.
Maternal control of triploid seed development by the TRANSPARENT TESTA 8 (TT8) transcription factor in Arabidopsis thaliana
Authors: Zumajo-Cardona Cecilia , Aguirre Manuel , Castillo-Bravo Rosa , Mizzotti Chiara , Di Marzo Maurizio , Banfi Camilla , Mendes Marta A. , Spillane Charles , Colombo Lucia , Ezquer Ignacio 
Published: January 2023

AbstractThe balance between parental genome dosage is critical to offspring development in both animals and plants. In some angiosperm species, despite the imbalance between maternally and paternally inherited chromosome sets, crosses between parental lines of different ploidy may result in viable offspring. However, many plant species, likeArabidopsis thaliana, present a post-zygotic reproductive barrier, known as triploid block which results in the inability of crosses between individuals of different ploidy to generate viable seeds but also, in defective development of the seed. Several paternal regulators have been proposed as active players in establishing the triploid block. Maternal regulators known to be involved in this process are some flavonoid biosynthetic (FB) genes, expressed in the innermost layer of the seed coat. Here we explore the role of selected flavonoid pathway genes in triploid block, includingTRANSPARENT TESTA 4(TT4), TRANSPARENT TESTA 7(TT7), SEEDSTICK(STK), TRANSPARENT TESTA 16(TT16), TT8andTRANSPARENT TESTA 13(TT13). This approach allowed us to detect thatTT8, a bHLH transcription factor, member of this FB pathway is required for the paternal genome dosage, as loss of functiontt8, leads to complete rescue of the triploid block to seed development.
Effect of Mo doping in NiO nanoparticles for structural modification and its efficiency for antioxidant, antibacterial applications
Authors: Alam Mir Waqas , BaQais Amal , Mir Tanveer Ahmad , Nahvi Insha , Zaidi Noushi , Yasin Amina 
Published: January 2023

AbstractNovel molybdenum (Mo)-doped nickel oxide (NiO) Nanoparticles (NPs) were synthesized by using a simple sonochemical methodology and the synthesized NPs were investigated for antioxidant, and antibacterial applications. The X-ray diffraction (XRD) analysis revealed that the crystal systems of rhombohedral (21.34 nm) and monoclinic (17.76 nm) were observed for pure NiO and Mo-doped NiO NPs respectively. The scanning electron microscopy (SEM) results show that the pure NiO NPs possess irregular spherical shape with an average particle size of 93.89 nm while the Mo-doped NiO NPs exhibit spherical morphology with an average particle size of 85.48 nm. The ultraviolet–visible (UV–Vis) spectrum further indicated that the pure and Mo-doped NiO NPs exhibited strong absorption band at the wavelengths of 365 and 349 nm, respectively. The free radical scavenging activity of NiO and Mo-doped NiO NPs was also investigated by utilizing several biochemical assays. The Mo-doped NiO NPs showed better antioxidant activity (84.2%) towards ABTS. + at 200 µg/mL in comparison to their pure counterpart which confirmed that not only antioxidant potency of the doped NPs was better than pure NPs but this efficacy was also concentration dependant as well. The NiO and Mo-doped NiO NPs were further evaluated for their antibacterial activity against gram-positive (Staphylococcus aureus and Bacillus subtilis) and gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains. The Mo-doped NiO NPs displayed better antibacterial activity (25 mm) against E. coli in comparison to the pure NPs. The synthesized NPs exhibited excellent aptitude for multi-dimensional applications.
Development of a clinical tool for rating categories of the ICF Rehabilitation Set in Polish practice
Authors: Wiśniowska-Szurlej Agnieszka , Ćwirlej-Sozańska Agnieszka , Wilmowska-Pietruszyńska Anna , Sozański Bernard 
Published: January 2023

AbstractRehabilitation is considered a key health strategy in the 21st century. The aim of rehabilitation is to optimize the functioning of patients. The International Classification of Functioning, Disability and Health (ICF) is a framework for describing and organizing information on functioning and disability. Current international efforts to implement ICF in rehabilitation practise include the implementation of ICF Core Sets and operationalize ICF tools for clinics. The aim of the study is to create simple, intuitive descriptions and an initial reference guide for the assessment of the ICF Rehabilitation Set in Polish practice. The development of the Polish version of ICF Rehabilitation Set involved the following steps: (1) identification of ICF Rehabilitation Set categories; (2) development simple, intuitive descriptions; (3) the drafting of the rating reference guide by a multidisciplinary panel following the process employed to develop the Japanese version. The Polish version of ICF Rehabilitation Set, the simple, intuitive descriptions for 29 categories and the rating reference guides were successfully developed. The Polish version of ICF Rehabilitation Set proposed by us is a reference framework for the harmonization of existing information on the functioning and disability of people participating in the rehabilitation process.
1/f laws found in non-human music
Authors: Jermyn Adam S. , Stevenson David J. , Levitin Daniel J. 
Published: January 2023

AbstractA compelling question at the intersection of physics, neuroscience, and evolutionary biology concerns the extent to which the brains of various species evolved to encode regularities of the physical world. It would be parsimonious and adaptive, for example, for brains to evolve an innate understanding of gravity and the laws of motion, and to be able to detect, auditorily, those patterns of noises that ambulatory creatures make when moving about the world. One such physical regularity of the world is fractal structure, generally characterized by power-law correlations or 1/f β spectral distributions. Such laws are found broadly in nature and human artifacts, from noise in physical systems, to coastline topography (e.g., the Richardson effect), to neuronal spike patterns. These distributions have also been found to hold for the rhythm and power spectral density of a wide array of human music, suggesting that human music incorporates regularities of the physical world that our species evolved to recognize and produce. Here we show for the first time that 1/fβ laws also govern the spectral density of a wide range of animal vocalizations (music), from songbirds, to whales, to howling wolves. We discovered this 1/fβ power-law distribution in the vocalizations within all of the 17 diverse species examined. Our results demonstrate that such power laws are prevalent in the animal kingdom, evidence that their brains have evolved a sensitivity to them as an aid in processing sensory features of the natural world.
A spatial analysis of TB cases and abnormal X-rays detected through active case-finding in Karachi, Pakistan
Authors: Zaidi Syed Mohammad Asad , Jamal Wafa Zehra , Mergenthaler Christina , Azeemi Kiran Sohail , Van Den Berge Nick , Creswell Jacob , Khan Aamir , Khowaja Saira , Habib Shifa Salman 
Published: January 2023

AbstractTuberculosis (TB) is the leading cause of avoidable deaths from an infectious disease globally and a large of number of people who develop TB each year remain undiagnosed. Active case-finding has been recommended by the World Health Organization to bridge the case-detection gap for TB in high burden countries. However, concerns remain regarding their yield and cost-effectiveness. Data from mobile chest X-ray (CXR) supported active case-finding community camps conducted in Karachi, Pakistan from July 2018 to March 2020 was retrospectively analyzed. Frequency analysis was carried out at the camp-level and outcomes of interest for the spatial analyses were mycobacterium TB positivity (MTB+) and X-ray abnormality rates. The Global Moran’s I statistic was used to test for spatial autocorrelation for MTB+ and abnormal X-rays within Union Councils (UCs) in Karachi. A total of 1161 (78.1%) camps yielded no MTB+ cases, 246 (16.5%) camps yielded 1 MTB+, 52 (3.5%) camps yielded 2 MTB+ and 27 (1.8%) yielded 3 or more MTB+. A total of 79 (5.3%) camps accounted for 193 (44.0%) of MTB+ cases detected. Statistically significant clustering for MTB positivity (Global Moran’s I: 0.09) and abnormal chest X-rays (Global Moran’s I: 0.36) rates was identified within UCs in Karachi. Clustering of UCs with high MTB positivity were identified in Karachi West district. Statistically significant spatial variation was identified in yield of bacteriologically positive TB cases and in abnormal CXR through active case-finding in Karachi. Cost-effectiveness of active case-finding programs can be improved by identifying and focusing interventions in hotspots and avoiding locations with no known TB cases reported through routine surveillance.
A comprehensive analysis of chromosomal polymorphic variants on reproductive outcomes after intracytoplasmic sperm injection treatment
Authors: Ralapanawe Madara S. B. , Gajaweera Sugandika L. , Karunaratne Nishendra , Dissanayake Vajira H. W. , Price Malcolm J. , Melo Pedro , Coomarasamy Arri , Gallos Ioannis D. 
Published: January 2023

AbstractRecent studies suggest that chromosomal polymorphic variations are associated with infertility. A systematic review of chromosomal polymorphisms in assisted reproduction found an association with higher rates of miscarriage. Aim of this study is to analyse the influence of specific types or number of chromosomal polymorphic variations on reproductive outcomes of couples undergoing ICSI treatment. We analysed data from 929 fresh and frozen embryo transfer cycles of 692 women who underwent karyotyping analysis using Giemsa-Trypsin-Leishman (GTL) banding prior to the ICSI procedure at the Fertility Centre of Lanka Hospitals Corporation Plc, Sri Lanka, from January 2016 to December 2018. The outcomes of interest were the pregnancy, miscarriage and live birth rate per cycle. There was no evidence of a difference in the reproductive outcomes between carriers or non-carriers of any type or number of chromosomal polymorphic variation. Our data, in contrast to previous studies, does not support a deleterious effect for the type or number of chromosomal polymorphic variations on reproductive outcomes. However, additional prospective, adequately powered studies, conducted in multiethnic populations, are required to further investigate whether the detection of chromosomal polymorphic variants prior to assisted conception may in fact be a futile diagnostic tool.
Mutated genes on ctDNA detecting postoperative recurrence presented reduced neoantigens in primary tumors in colorectal cancer cases
Authors: Nagayama Satoshi , Kobayashi Yuta , Fukunaga Mitsuko , Sakimura Shotaro , Sugimachi Keishi , Sasaki Shin , Masuda Takaaki , Mafune Ken-ichi , Oshima Masanobu , Shibata Tatsuhiro , Suzuki Yutaka , Mimori Koshi 
Published: January 2023

AbstractThe detection and sequencing of the mutated ctDNA is one of the irreplaceable clinical measures in the postoperative management of colorectal cancer (CRC) cases. However, we are curious to comprehend the essential traits of mutated genes comprising metastatic sites out of whole mutated genes in primary sites. In the current retrospective study, we conducted target resequencing of ctDNA using 47 plasma samples and established a cancer panel carrying the commonly mutated genes between primary and recurrent tumors. We found that mutated genes in ctDNA indicated immune-resistance traits with respect to the impaired ability to present neoantigens by loss of expression or binding affinity to HLA in the primary tumor. Compared with the estimated neoantigens from all mutated genes in primary tumors, the neoantigen peptides from commonly mutated genes on the panel showed abundant expression but no binding affinity to HLA. Therefore, ctDNA mutations can be frequently and postoperatively detected to identify recurrence; however, these mutated genes were derived from immune-tolerated clones owing to the loss of neoantigen presentation in primary CRC tumors.
Facile synthesis of NiTe2-Co2Te2@rGO nanocomposite for high-performance hybrid supercapacitor
Authors: Farshadnia Maziar , Ensafi Ali A. , Mousaabadi Kimia Zarean , Rezaei Behzad , Demir Muslum 
Published: January 2023

AbstractThe design of bimetallic tellurides that exhibit excellent electrochemical properties remains a huge challenge for high-performance supercapacitors. In the present study, tellurium is consolidated on CoNi2@rGO for the first time, to synthesize NiTe2-Co2Te2@rGO nanocomposite by using a facile hydrothermal method. As-prepared NiTe2-Co2Te2@rGO nanocomposite was characterized by EDS, TEM, FESEM, Raman, BET, XRD, and XPS techniques to prove the structural transformation. Upon the electrochemical characterization, NiTe2-Co2Te2@rGO has notably presented numerous active sites and enhanced contact sites with the electrolyte solution during the faradic reaction. The as-prepared nanocomposite reveals a specific capacity of 223.6 mAh g−1 in 1.0 M KOH at 1.0 A g-1. Besides, it could retain 89.3% stability after 3000 consecutive galvanostatic charge–discharge cycles at 1.0 A g−1 current density. The hybrid supercapacitor, fabricated by activated carbon as an anode site, and NiTe2-Co2Te2@rGO as a cathode site, presents a potential window of 1.60 V with an energy density of 51 Wh kg−1 and a power density of 800 W kg−1; this electrode is capable of lighting up two red LED lamps and a yellow LED lamp for 20 min, which is connected in parallel. The present work opens new avenues to design and fabrication of nanocomposite electrode materials in the field of supercapacitors.