Clinical observation of choroidatong pill combined with daheline in the recovery of parathyroid function after total thyroidectomy
Authors: Liu JiaQi , Chu Jun , Kong Linna , Ding Yu 
Published: August 2023

Abstract
Background:With the rapid rise of thyroid cancer incidence, how to prevent and deal with thyroid surgery postoperative complications is an important topic and challenge faced by surgeons. Among them, hypoparathyroidism is the most common complication after total thyroidectomy, which can significantly reduce the postoperative quality of life and increase the treatment cost of patients. Based on this, this study discusses the use of chorosutong pill and daheparin in the treatment of hypoparathyroidism after total thyroidectomy, which is intended to be.
Methods: Using a retrospective analysis, A total of 928 thyroid cancer patients with total thyroid resection and lymph node dissection in the central district in the first ward of Breast and thyroid Surgery Department of Zibo Central Hospital from May 2021 to October 2022 were collected, A total of 261 patients had decreased parathyroid gland function after surgery; Among them, 151 patients (anticoagulant group) were given chorosutong pill combined with daheparin anticoagulation therapy and calcium supplement therapy on the first postoperative day, The 110 patients (control group) received only postoperative calcium supplementation, The incidence of permanent hypoparathyroidism, the average time to return to normal, the average postoperative extubation time and the average diversion flow of both groups were counted; The efficacy, serum PTH, and calcium values were compared between the two groups.
Results: The incidence of permanent hypoparathyroidism in the anticoagulant group was 0%, The incidence of permanent hypoparathyroidism in the control group was 3.64%, The permanent parathyroid damage rate in the anticoagulant group was less than that in the control group (P <0.05), The mean postoperative extubation time between the two groups (P=0.28), There was no significant difference in mean postoperative diversion between the two groups (P=0.59), The postoperative parathyroid glands recovered significantly faster at 15,30,90 and 180 days than that in the control group (P <0.05); postoperative, The PTH index varied significantly between the two groups, The main manifestations are, as time goes on, The PTH measures were significantly higher in both groups, And Compared with the control group, The PTH was significantly higher in the anticoagulant group; postoperative, Significant differences in serum calcium index between the two groups, Both serum calcium indexes with the postoperative time, The expression was significantly elevated, And Compared with the control group, Serum calcium was significantly higher in the anticoagulant group; After intervention in both groups, There were significant differences in the efficacy, The main manifestation was that the treatment effect of the anticoagulant group was significantly better than that of the control group (P <0.05).
Conclusion: Low parathyroid function occurs after total thyroidectomy, chorosutong pill and heparin anticoagulant therapy, can promote the recovery of parathyroid function, improve PTH and serum calcium, high clinical efficiency, and can reduce the incidence of permanent functional impairment, and use safe and reliable after surgery.