bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the Slant-Path Effect in the Simulation of Clear-Sky Thermal Radiance for the GK2A AMI
Authors: Lee Su Jeong , Ahn Myoung-Hwan 
Published: February 2023

Abstract
Taking the slanted satellite viewing geometry into account is important in the simulation of satellite radiances, which vary with the atmospheric conditions along the line of sight. As a first step to take the slanted satellite viewing geometry into account in the numerical weather prediction system operated in the Korean Meteorological Administration, the slant-path modeling is applied for the simulation of clear-sky thermal radiances of a geostationary satellite imager, the Advanced Meteorological Imager (AMI) on board the Geo-KOMPSAT-2A (GK2A). The observations minus simulations (O − B) and the Jacobians before and after the slant-path calculation are compared. Since most infrared channels of AMI are not sensitive to the atmosphere above the tropopause, the size of slant-path effect for AMI is overall smaller than the effect shown in the microwave sounders. Still, the slant-path modeling is found to have a noticeable effect on the three water vapor absorption channels of AMI peaking between 300 and 600 hPa, particularly at large satellite zenith angles and on the regions with high water vapor variabilities in the model field along the line of sight. On average, the slant-path interpolation reduces the standard deviation of O − B of the water vapor channels by around 2.0% on land and 1.4% over the ocean for zenith angles 40°–60°, and it also influences not only the shape and magnitude but also the height of the peak of the Jacobians. In addition, the retrieval experiment based on the optimal estimation also demonstrates the impact of this new approach in the retrieved moisture field, though the improvement is not as significant as shown in the simulation experiment.
Convection Initiation Associated with a Boundary Layer Convergence Line over a Real-World Sharp Vegetation-Contrast Area
Authors: Liu Hongjun , Meng Zhiyong , Zhu Yuning , Huang Yipeng 
Published: February 2023

Abstract
Convection initiation (CI) has remained a major challenge in weather forecasting worldwide. The Hetao area in North China, the location of Asia’s largest irrigation area, contains highly heterogeneous vegetation where near-surface convergence lines (boundaries) parallel to the oasis–desert border often emerge over the desert and initiate convection. This study investigated the evolution of such a boundary and its influence on the CI process where a series of cells were successively initiated along the boundary on 4 June 2013. Our results indicated that uneven surface heating across the oasis–desert border produced mesoscale thermal circulation. The westerly oasis breeze in the thermal circulation converged with the southerly background wind and formed a boundary over the desert along the high-temperature contrast line. A middle-hemisphere westerly trough further enhanced uplift and facilitated CI. Our simulation revealed that the first 30-dBZ parcels in each cell originated from either the desert side at a low level or the oasis side at a middle level, rather than from the oasis at a low level, as indicated by previous idealized studies. Southerly low-level parcels veered above the boundary and experienced a longer lifting time over the desert, while western parcels originating from the oasis experienced a shorter lifting time and smaller vertical displacement, resulting in middle-level parcels instead of low-level parcels that reached their level of free convection. Even though CI occurred over a surface boundary without a near-surface stable layer, the inflow may have originated from middle levels rather than in contact with the surface.

Significance Statement
The purpose of this study is to understand the evolution of a real-world near-surface convergence line and the associated deep convection initiation (CI) along the border of Asia’s largest irrigation area and the desert in northern China. Notably, previous works have mainly focused on shallow convection over uneven vegetation distributions based on idealized simulations, which may be quite different from real-world interactions between thermal circulation and background flow. Our results highlight different parcel sources in different convections initiated by the same convergence line, which is different from the idealized situation where parcels mainly originate from the low-level oasis side.
Cross-sectional audit assessing the quality of dried bloodspot specimens received by UK metabolic biochemistry laboratories for the biochemical monitoring of individuals with Phenylketonuria
Authors: Hogg Sarah L , Carling Rachel S , Cantley Nathan WP , Hamilton Gillian , Goddard Philippa , Aitkenhead Helen , Barski Robert , Collingwood Catherine , Moat Stuart J , Kemp Helena J 
Published: February 2023

Background Sapropterin has been approved as a treatment option for individuals with Phenylketonuria in the United Kingdom. Individuals are assessed as responsive to Sapropterin by a ≥30% reduction in Phenylalanine (Phe) concentrations using dried blood spot (DBS) specimens. DBS quality is critical for accurate and precise measurement of Phe. Currently, UK national guidelines for DBS specimen acceptance do not exist for patient-collected DBS specimens. We adopted evidence-based guidelines for specimen acceptance criteria and retrospectively assessed the impact of introducing these guidelines on specimen rejection rates. Methods: Laboratories were invited to audit the quality of DBS specimens routinely received for Phe monitoring using: (1) existing acceptance/rejection criteria and (2) proposed national guidelines. Results Ten laboratories audited 2111 specimens from 1094 individuals. Using existing local guidelines, the median rejection rate was 4.0% (IQR 1.5–7.2%). This increased to 21.9% (IQR 10.0–33.0%) using the proposed guidelines. Where reason(s) for rejection were provided ( n = 299); 211/299 (70.6%) of DBS specimens were too small or multi-spotted. 380 individuals had more than one sample evaluated; 231/380 (60.8%) provided specimens of acceptable quality, 37/380 (9.7%) consistently provided poor-quality DBS specimens. Conclusions There is significant variability in the quality of patient-collected DBS specimens. If unacceptable specimens are not rejected, imprecise/inaccurate results will be used in clinical decision making. Using annual workload data for England, this equates to 12,410 incorrect results. Individuals and parents/carers should receive ongoing training in blood collection technique to ensure use of evidence-based acceptability criteria does not cause undue distress from increased sample rejection rates.
Hepcidin analysis in pneumonia: Comparison of immunoassay and LC-MS/MS
Authors: Oppen Kjersti , Brede Cato , Skadberg Øyvind , Steinsvik Trude , Holter Jan Cato , Michelsen Annika E , Heggelund Lars 
Published: February 2023

Background The iron-regulatory hormone hepcidin is a promising biomarker to differentiate anaemia of inflammation from iron deficiency. Plasma hepcidin concentrations increase substantially during inflammation, and the amount of smaller, non-biologically active isoforms of hepcidin increase in inflammatory conditions. These smaller isoforms are measured in some, but not all analytical methods. Thus, we evaluated the comparability of two analytical methods with different isoform selectivity during and after acute-phase pneumonia as a highly inflammatory model disease. Methods Blood samples from a cohort of 267 hospitalized community-acquired pneumonia patients collected at admission and a 6-week follow-up were analysed. Hepcidin was measured in plasma by an immunoassay, which recognizes all hepcidin isoforms, and a liquid chromatography tandem mass spectrometry (LC-MS/MS), which selectively measures the bioactive hepcidin-25. Additionally, a subset of serum samples was analysed by LC-MS/MS. Results Hepcidin measurements by immunoassay were higher compared with LC-MS/MS. The relative mean difference of hepcidin plasma concentrations between the two analytical methods was larger in admission samples than in follow-up samples (admission samples <200 ng/mL: 37%, admission samples >200 ng/mL: 78%, follow-up samples >10 ng/mL: 22%). During acute-phase pneumonia, serum concentrations were on average 22% lower than plasma concentrations when measured by LC-MS/MS. Conclusions Immunoassay measured higher hepcidin concentrations compared with LC-MS/MS, with more pronounced differences in high-concentration samples during acute-phase pneumonia. These findings should be considered in local method validations and in future harmonization and standardization optimization of hepcidin measurements.
Center-Left Parties and Developmental Regimes in Latin America: Assessing the Role of Democracy
Authors: da Silva Pedro Perfeito , Bandeira Julia Veiga Vieira Mancio 
Published: February 2023

Comparison of the paths of two countries with developmental regimes led by left-of-center parties, Chile and Mexico, shows that the democratic regime, Chile’s, had better social indicators than its authoritarian counterpart at the price of slower industrialization. Comparação das trajetórias de dois países com regimes desenvolvimentistas dirigidos por partidos do centro-esquerda no Chile e México demostra que o regime democrâtico chileno teve maiores indicadores sociais que sua contraparte autoritária às custas de uma industrialização mais lenta.
Deep learning-extracted CT imaging phenotypes predict response to total resection in colorectal cancer
Authors: Pan Xiang , Cong He , Wang Xiaolei , Zhang Heng , Ge Yuxi , Hu Shudong 
Published: February 2023

BackgroundDeep learning surpasses many traditional methods for many vision tasks, allowing the transformation of hierarchical features into more abstract, high-level features.PurposeTo evaluate the prognostic value of preoperative computed tomography (CT) image texture features and deep learning self-learning high-throughput features (SHF) on postoperative overall survival in the treatment of patients with colorectal cancer (CRC).Material and MethodsThe dataset consisted of 810 enrolled patients with CRC confirmed from 10 November 2011 to 10 February 2018. In contrast, SHF extracted by deep learning with multi-task training mechanism and texture features were extracted from the CT with tumor volume region of interest, respectively, and combined with the Cox proportional hazard (CoxPH) model for initial validation to obtain a RAD score to classify patients into high- and low-risk groups. The SHF stability was further validated in combination with Neural Multi-Task Logistic Regression (N-MTLR) model. The overall recognition ability and accuracy of CoxPH and N-MTLR model were evaluated by C-index and Integrated Brier Score (IBS).ResultsSHF had a more significant degree of differentiation than texture features. The result is (SHF vs. texture features: C-index: 0.884 vs. 0.611; IBS: 0.025 vs. 0.073) in the CoxPH model, and (SHF vs. texture features: C-index: 0.861 vs. 0.630; IBS: 0.024 vs. 0.065) in N-MTLR.ConclusionSHF is superior to texture features and has potential application for the preoperative prediction of the individualized treatment of CRC.
The possibility of visualizing TGF-β1 expression in ApoE−/− mice atherosclerosis using MR targeted imaging
Authors: Xia Min , Wu Fen , Yang Yawen , Lu Wenye , Song Mengxing , Ma Zhanlong 
Published: February 2023

Background Endothelial TGF-β1 signaling is a primary driver of atherosclerosis-associated vascular inflammation. Targeted imaging and inhibition of the expression of TGF-β1 may reduce the atherosclerotic vessel wall inflammation and stop the progression of atherosclerotic plaque. Purpose To investigate the possibility of the anti-TGF-β1-ultrasmall superparamagnetic iron oxide (USPIO) specific probe as an imaging marker for the expression of TGF-β1 in ApoE–/– mice atherosclerosis detected with 7.0-T magnetic resonance imaging (MRI). Material and Methods Here, 70 ApoE–/– mice on a high-fat diet served as the experimental group and 30 C57BL/6 mice on a normal diet served as the control group. The morphology of plaques was viewed by H&E staining, and the expression and distribution of TNC and TGF-β1 were detected by immunohistochemical staining. Another 40 mice in the experimental group were classified into a targeted group, which was administrated an anti-TGF-β1-USPIO probe, and the pure group, which was injected with pure USPIO. Results The 7.0-T MRI showed that the relative signal intensity (rSI) changes of the targeted group decreased more than those of the pure group (−19.34 ± 0.68% vs. −5.61 ± 0.57%; P < 0.05). Histopathological analyses demonstrated expression of TGF-β1 in atherosclerotic plaque formation progression from 10 to 28 weeks. The MR images of the expression of TGF-β1 in atherosclerosis correlated well with the pathological progression of atherosclerotic plaque formation. Conclusions Anti-TGF-β1-USPIO could provide a useful molecular imaging tool for detecting and monitoring the expression of TGF-β1 in atherosclerotic plaques by MRI.
Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization
Authors: Vila-Pueyo Marta , Cuenca-León Ester , Queirós Ana C. , Kulis Marta , Sintas Cèlia , Cormand Bru , Martín-Subero José Ignacio , Pozo-Rosich Patricia , Fernàndez-Castillo Noèlia , Macaya Alfons 
Published: February 2023

Background Cortical spreading depolarization, the cause of migraine aura, is a short-lasting depolarization wave that moves across the brain cortex, transiently suppressing neuronal activity. Prophylactic treatments for migraine, such as topiramate or valproate, reduce the number of cortical spreading depression events in rodents. Objective To investigate whether cortical spreading depolarization with and without chronic treatment with topiramate or valproate affect the DNA methylation of the cortex. Methods Sprague-Dawley rats were intraperitoneally injected with saline, topiramate or valproate for four weeks when cortical spreading depolarization were induced and genome-wide DNA methylation was performed in the cortex of six rats per group. Results The DNA methylation profile of the cortex was significantly modified after cortical spreading depolarization, with and without topiramate or valproate. Interestingly, topiramate reduced by almost 50% the number of differentially methylated regions, whereas valproate increased them by 17%, when comparing to the non-treated group after cortical spreading depolarization induction. The majority of the differentially methylated regions lay within intragenic regions, and the analyses of functional group over-representation retrieved several enriched functions, including functions related to protein processing in the cortical spreading depolarization without treatment group; functions related to metabolic processes in the cortical spreading depolarization with topiramate group; and functions related to synapse and ErbB, MAPK or retrograde endocannabinoid signaling in the cortical spreading depolarization with valproate group. Conclusions Our results may provide insights into the underlying physiological mechanisms of migraine with aura and emphasize the role of epigenetics in migraine susceptibility.
Research and analysis on computed tomography signs and clinical characteristics of chronic duodenal papilla mucositis and duodenal papillary carcinoma
Authors: Wei Wenyan , Mo Weixing , Wang Ning , Li Qinghai 
Published: February 2023

Objective: To investigate the computed tomography (CT) findings of chronic duodenal papilla mucositis and duodenal papillary carcinoma, and provide more imaging information for early diagnosis of duodenal malignant diseases. Methods: CT findings and clinical data of 40 patients with chronic duodenal papilla mucositis and 46 patients with duodenal papillary carcinoma were retrospectively analyzed. Observation and measuring of direct duodenal papilla signs (including size, shape, density, enhancement uniformity, etc.), indirect duodenal papilla signs (including pancreaticobiliary dilatation) and clinical indicators (including tumor markers CA19-9, CA125, CEA, blood routine white blood cell count, bilirubin, age, gender, etc.) were carried out according to CT as well as statistical analysis. Results: There were significant differences in duodenal papilla regular morphology, age and CA19-9 ( p < .05), and significant differences in duodenal papilla maximum transverse diameter, diameter of common bile duct, diameter of pancreatic duct, total bilirubin, direct bilirubin, and jaundice in duodenal papillary carcinoma group ( p < 0.01). There were no significant differences in duodenal papilla enhancement uniformity, plain CT value, arterial CT value, portal CT value, enhancement uniformity, presence or not of calculus at the lower end, gender, CEA, CA125, white blood cell count, and abdominal pain with fever (all p > .05). Conclusion: CT is helpful for the diagnosis of duodenal papilla disease, but the CT findings of patients with duodenal papillary carcinoma tend to be similar to findings of chronic duodenal papilla mucositis, which is easy to lead to misdiagnosis, so comprehensive diagnosis should be made according to the direct and indirect CT signs as well as laboratory and clinical manifestations of duodenal papilla, so as to improve the diagnosis of duodenal papillary carcinoma, and reduce missed diagnosis and misdiagnosis.
Sustainable wheat gluten foams with self-expansion and water/blood-triggered shape recovery
Authors: Chen Tuying , Tang Yingzi , Zhao Huijing , Zhang Keqin , Meng Kai 
Published: February 2023

A cheap and easily obtainable wheat gluten (WG) was used to fabricate bio-foams via a simple method of stirring, heating, and lyophilization. The foam possesses a 3D layered porous structure with interconnected channels, and the biofoam has excellent mechanical properties through glycerol plasticization and glutaraldehyde (GA) cross-linking. The water absorption and volume expansion rate can reach 793.67 ∼ 918.45% and 201.47 ∼ 239.53% respectively. In dry state, the foams had good compression resilience, and can basically recover its original shape after withstanding 60% compression strain for about 7 h. In wet state, they can withstand 10 cycles of compression test, and had good compressive resilience and durability; they also had fast liquid-triggered shape recovery performance, of which the foams can reabsorb liquid, expand, and recover its original shape within 40 seconds after withstanding 80% compression strain. In addition, The hemolysis rates of red blood cells treated with 1, 3, and 5 mg/mL of 14WG-20g-5GA foam suspension were 0.53 ± 0.12%, 2.12 ± 0.34%, and 3.97 ± 0.21%, respectively, all of which were below the permissible range for biological materials (<5%). The above-mentioned advantages made the sustainable foams be potentially useful for medical dressings, especially for the treatment of non-compressible haemorrhaging, which offered a new field of application for WG protein and its added value was also increased obviously.
Relationship Between Premature Birth and Acquired Heart Disease in Adulthood: A Meta-analysis and Systematic Review
Authors: Mongkonsritragoon Wimwipa , Tokavanich Nithi , Prasitlumkum Narut , Chokesuwattanaskul Ronpichai , Cheungpasitporn Wisit , Chiengthong Kanhatai 
Published: February 2023

Introduction Premature birth has a causal relationship with hypertension and diabetes, which are significant risk factors for major cardiovascular disease. Nonetheless, little is known whether premature birth portends future risks of acquired heart diseases, for example, ischemic heart disease (IHD), heart failure (HF), and valvular heart disease (VHD). Methods We comprehensively searched the databases of MEDLINE, EMBASE, and Cochrane database from inception to December 2021. Studies with prospective and retrospective cohort designs that reported the association between premature birth and acquired heart disease, including IHD, HF, and VHD, were included. Data from each study were combined with a random-effects model. The results were reported in the hazard ratio (HR) with 95% confidence intervals. Results The selected studies were comprised of 7 studies, with 5 studies involving premature birth and the development of IHD in adulthood and 2 studies involving premature birth and HF. No studies reporting the relationship between premature birth and VHD met our initial inclusion criteria. Our study did not find any association between premature birth and IHD in the adulthood (HR 1.14 95% CI 0.91-1.19, P = .16, I2 = 51%). We found the association between premature birth and acquired HF (HR 1.53 95% CI 1.08-2.16, P = .01, I2 = 0) Conclusion Premature birth was not statistically associated with IHD in adulthood, but there was a significant association between preterm and HF.
Vitiligo-like lesions associated with ribociclib in a woman with metastatic breast cancer
Authors: Türkel Alper , Karaçin Cengiz , Öner İrem , Şeyran Erdoğan , Öksüzoğlu Berna 
Published: February 2023

Introduction Cyclin-dependent kinase 4/6 inhibitors are new generation drugs that have recently been used in patients with hormone receptor-positive and human epidermal growth factor receptor 2-negativenegative metastatic breast cancer. Recent studies have shown that the use of cyclin-dependent kinase 4/6 inhibitors significantly improves the outcomes of these patients. The most common side effects of cyclin-dependent kinase 4/6 inhibitors are hematological toxicity, gastrointestinal side effects, and fatigue. We aimed to present a case of metastatic breast cancer who was treated with ribociclib and developed vitiligo-like lesions after treatment. Case report A 56-year-old female patient was diagnosed with locally advanced hormone receptor (+)/human epidermal growth factor receptor 2 (−) breast cancer in May 2000. She was followed up with hormonal therapy after adjuvant chemotherapy and radiotherapy. The patient progressed with lung metastases in 2012. Ribociclib, anastrozole, and leuprolide acetate were started in November 2021 after multiple-line chemotherapy. After six cycles of ribociclib, vitiligo-like lesions that developed in the last 1 month were detected on the upper extremities, both hands, neck, chest, and upper back. Management and outcome The patient was referred to dermatology. Topical immunosuppressive therapy and oral corticosteroids were recommended. At the first and third-month follow-up examinations, vitiligo-like lesions were observed to persist. Discussion Vitiligo-like lesions are not a life-threatening side effect. However, it significantly affects the quality of life and disrupts the patient's compliance with treatment. Cyclin-dependent kinase 4/6 inhibitors can inhibit cell division or cause premature cell death by acting on the melanocyte cell cycle.