bluuebunny/crossref_metadata_2025_split huggingface dataset:
Millennials, the Most Afflicted Generation
Authors: Holden Brittany A. , Dwyer Jessica B. 
Published: June 2023

Abstract
In the wake of the SARS-CoV-2 (COVID-19) pandemic, mental health has become a pivotal topic of discussion nationwide.
1,2
Recognition of mental health disorders, mitigation of psychological distress during times of uncertainty, and abating negative stigma have become a focus of many groups, both internal and external to the medical field. Still, one of the most devastating sequelae of mental health afflictions is suicide.
A retrospective review of all cases classified as suicide from January 2019 through December 2021 was conducted using the laboratory information system database within the Southwestern Institute of Forensic Sciences, the county division that performs postmortem examinations of cases under the jurisdiction of Dallas County and some surrounding North Texas counties. A total of 846 cases were retrieved that occurred within Dallas County. This cohort consisted of 659 men and 187 women with an average age of 42.9 years (median, 40 years). This study highlights compelling trends of suicides within a localized portion of North Texas during a 3-year period in which the population endured momentous and unprecedented worldwide events.
Evaluation of Peripapillary and Macular Optical Coherence Tomography Angiography Characteristics in Different Stages of Papilledema
Authors: Pahuja Akshra , Dhiman Rebika , Aggarwal Vasudha , Aalok Swati P. , Saxena Rohit 
Published: June 2023

Background:
Prospective evaluation of optical coherence tomography (OCT) and OCT angiography (OCT-A) characteristics in different stages of papilledema in idiopathic intracranial hypertension (IIH).

Methods:
In this prospective, observational study patients of IIH with papilledema were recruited and divided into 3 groups—early/established (Group 1), chronic (Group 2), and atrophic papilledema (Group 3). Peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell inner plexiform layer (GC-IPL) were recorded on OCT. Peripapillary and macular perfusion was documented at superficial retinal, deep retinal, and choriocapillary level using OCT-A. The investigations were repeated at 3 months.

Results:
RNFL showed significant thinning in all groups on follow-up with the atrophic group showing maximum thinning (P = 0.01—Group 3). GC-IPL was significantly reduced in all stages of papilledema at baseline compared with the controls. Thinnest GC-IPL was noted in the atrophic group (52.75 ± 7.44 μm; P = 0.00 in Group 3 vs controls) that showed further deterioration on follow-up. On Image J analysis, significant decrease was noted at various levels in the peripapillary and macular perfusion at baseline especially in the atrophic group which showed further deterioration noted on follow-up. The final visual acuity showed a statistically significant weak negative correlation with baseline RNFL (r = −0.306) and GC-IPL (r = −0.384) and moderately negative correlation with baseline superficial peripapillary retinal perfusion (r = −0.553). A significant negative correlation was seen between increasing grade of papilledema and superficial peripapillary retinal perfusion with both Image J and automated indices (r = −0.46; r = −0.61), respectively.

Conclusions:
GC-IPL may help identify early damage in papilledema even in the presence of thicker RNFL. Significant vascular changes can be observed on OCT-A that may help predict the final visual outcome in papilledema due to IIH.
Inter-laboratory Variability of Caspofungin Minimum Inhibitory Concentrations for Nakaseomyces glabrata isolates – An Irish Tertiary Hospital Experience
Authors: Ali Saied , Collison Meadhbh , McNicholas Sinead , McDermott Sinead 
Published: June 2023

Background:
Nakaseomyces glabrata, formerly Candida glabrata, is an opportunistic yeast and an emerging cause of human infections. The use of broth microdilution (BMD) methodologies for caspofungin (CSP) antifungal susceptibility testing (AFST) against N. glabrata is reported to be prone to high inter-laboratory variation. We aimed to compare CSP minimum inhibitory concentrations (MICs) of N. glabrata isolates from our institution with those obtained by the Reference Laboratory for the same isolates.

Methods:
All clinically significant N. glabrata isolates from 2019-2021 inclusive were reviewed. AFST was performed locally using the VITEK2 system with the AST-YS08 card while E-tests were performed at Mycology Reference Laboratory (MRL), and agreement between these two methods was evaluated – categorical and essential.

Results:
41 isolates were reviewed during the study period – 30 from blood cultures, seven from intra-operative theatre specimens and four from sterile site drain fluids. Despite an essential agreement of 100% within ±2 log2 dilution, marked discrepancies were noted in interpretative breakpoints between assays with 17 Minor and 16 Major category errors. Categorical agreement was 19.5%, with the VITEK2 over-estimating resistance. A Mann-Whitney U Test assessed the relationship of MICs across the AFST modalities, and a statistically significant difference was noted, p<0.01, with a higher mean rank for VITKEK2 outputs.

Conclusion:
While the VITEK2 system is highly applicable, its performance for CSP AFST is unreliable and potentially results in the mis-classification of susceptible isolates as highlighted in our study. The use of VITEK2 AST-YS08 micafungin as a sentinel echinocandin should be explored and/or the evaluation of CSP-specific E-tests as utilised by the MRL. These methods appear more consistent and less prone to the variation seen with BMD for CSP.
A Dual Color Pax7 and Myf5 In Vivo Reporter to Investigate Muscle Stem Cell Heterogeneity in Regeneration and Aging
Authors: Ancel Sara , Michaud Joris , Sizzano Federico , Tauzin Loic , Oliveira Manuel , Migliavacca Eugenia , Dammone Gabriele , Karaz Sonia , Sánchez-García José L , Metairon Sylviane , Jacot Guillaume , Bentzinger C. Florian , Feige Jérôme N. , Stuelsatz Pascal 
Published: June 2023

SummaryIncreasing evidence suggests heterogeneity in the muscle stem cell (MuSC) pool. In particular, a rare subset of Pax7 positive MuSCs that has never expressed the myogenic regulatory factor Myf5 has enhanced self-renewal and engraftment characteristics. However, the scarcity and limited availability of protein markers make the characterization of these cells challenging. We describe the generation of StemRep reporter mice allowing to monitor Pax7 and Myf5 protein based on equimolar levels of dual nuclear fluorescence. High levels of Pax7 protein and low levels of Myf5 delineate a deeply quiescent MuSC subpopulation with distinct molecular signatures and dynamics of activation, proliferation, and commitment. Aging decreases the number of these cells, and skews the MuSC pool towards Myf5-Highcells with impaired quiescence. Altogether, we describe a novel deeply quiescent MuSC subpopulation whose maintenance is impaired in old muscles, and establish the StemRep line as a versatile tool to study quiescence and MuSC heterogeneity.
wTSA-CRAFT: an open-access web server for rapid analysis of thermal shift assay experiments
Authors: Reys Victor , Kowalewski Julien , Gelin Muriel , Lionne Corinne 
Published: June 2023

AbstractThe automated data processing provided by theTSA-CRAFTtool enables now to reach high throughput speed analysis of thermal shift assays. While the software is powerful and freely available, it still requires installation process and command line efforts that could be discouraging. To simplify the procedure, we decided to make it available and easy to use by implementing it with a graphical interface via a web server, enabling a cross-platform usage from any web browsers. We developed a web server embedded version of theTSA-CRAFTtool, enabling a user-friendly graphical interface for formatting and submission of the input file and visualization of the selected thermal denaturation profiles.We describe a typical case study of buffer condition optimization of the biologically relevant APH(3’)-IIb bacterial protein in a 96 deep-well thermal shift analysis screening. wTSA-CRAFTis freely accessible for non-commercial usage athttps://bioserv.cbs.cnrs.fr/TSA_CRAFT.
Assessment of diseases and insect pests of apple (Malus domesticaBorkh) in Silte Zone, Southern Ethiopia
Authors: Woto Sebsibe Sh. , Aloto Adimasu A. 
Published: June 2023

AbstractAssessment research was conducted in sixKebeles(administrative units) of Mirab azerenet and Alicho wuriro Districts of Silte Zone in 2021/21 cropping season, to assess the prevalence and damage of diseases and insect pests of apple and growers experience on pest identification and its management. A total of 60 apple growers were interviewed using a semi-structured questionnaire. Powdery mildew and apple scab were more damaging diseases of apple fruit tree in the area and they imply economic threat if not managed and also green apple aphid was the only recorded insect pest that caused leaf curling of apple fruit tree. About 71.7% of respondents were responded powdery mildew as number one disease of apple that hinders apple production. About 76.7% of producers were answered that they didn’t identified insect pests that attack their apple fruit tree. Out of the total respondents 90% (for diseases) and 16.7% (for insects) responded that, winter season was primary period for occurrence of these pests in their apple orchard/nursery. Out of the respondents 61.7% and 85% (for diseases and insect pests) responded that they don’t have any information about management methods. About 85% of respondents replied that, they don’t prune their apple fruit tree in the optimum season and also they don’t know its importance and the method. Generally, the result of current assessment revealed that, awareness of growers on crop agronomy, pest type and its infestation season, and management measures that taken so far were not encouraging. Based on the results of our survey, we recommend the following; timely awareness of apple fruit tree; agronomy, improvement and protection should be provided for growers by agricultural extension workers and other agents.
Evolution of Plasticity in Response to Ethanol between Recently Separated Populations ofD. melanogasterwith Different Ecological Histories
Authors: Boateng-Sarfo George , Scherping Franz , Mammadov Murad , Signor Sarah 
Published: June 2023

AbstractThe evolution of phenotype plasticity by genetic accommodation was theorized but has not been extensively demonstrated. Under this model of evolution when a population encounters a new environment there are widely variable responses amongst different genotypes, which are then pruned by selection into a single adaptive response. Because of the requirement to replicate genotypes, testing this predication requires inbred lines as well as populations that are both adapted and not adapted to a resource. We previously demonstrated thatD. melanogasteradapted to ethanol through genetic accommodation usingD. simulansas an ancestral proxy lineage. However, we wondered how generalizable these results were. Using a new population ofD. melanogasterfrom France and an ancestral range population from Zambia we demonstrated here that the Zambian population is not adapted to ethanol and that the French population has evolved ethanol resistance through genetic accommodation. We also investigated alternative splicing in response to ethanol and find that gene expression and splicing appear to evolve independently of one another, and that the splicing response to ethanol is largely distinct between populations. Thus we have independently replicated evidence for evolution by genetic accommodation inD. melanogaster, suggesting that the evolution of plasticity may be an important contributor to the ability to exploit novel resources.
The platyrrhine primateCebus imitatoruses gaze to adjust grasp posture for food handling and withdraw to the mouth
Authors: Whishaw Ian Q , Mah Megan , Casorso Julia G. , Chacon Evin Murillo , Chalk-Wilayto Janine , Laird Myra , Melin Amanda 
Published: June 2023

AbstractOrienting a food item held in the hand to withdraw it to the mouth for eating is mediated by vision in catarrhine anthropoids and by nonvisual strategies in strepsirrhines. The present study asks whether vision contributes to the withdraw in a platyrrhine anthropoid, a member of a monophyletic primate suborder whose stem group diverged from catarrhines about 40 million years ago. We examined gaze and hand use in arboreal fruit picking by the Costa Rican capuchin,Cebus imitator, a platyrrhine known for its skilled object-handling and tool use. Videos clips of reach, grasp and withdraw movements and associated gaze were examined frame-by-frame to assess hand shaping and sensory control of eating.Cebus imitatorused vision and touch to reach for and grasp food items with precision or whole hand grasps. They used vision to orient food items held inhand into a precision grip and their withdraw of food items to the mouth was assisted with a vertically oriented hand. The conjoint use of vision, grasp and hand posture by capuchins is discussed in relation to the staged evolution of visual manipulation of objects, one of which is featured in this platyrrhine primate.
Early subcortical response at the fundamental frequency of continuous speech measured with MEG
Authors: Schüller Alina , Schilling Achim , Krauss Patrick , Reichenbach Tobias 
Published: June 2023

AbstractMost parts of speech are voiced, exhibiting a degree of periodicity with a fundamental frequency and many higher harmonics. Some neural populations respond to this temporal fine structure, in particular at the fundamental frequency. This frequency-following response to speech (speech-FFR) consists of both subcortical and cortical contributions and can be measured through electroen-cephalography (EEG) as well as through magnetoencephalography (MEG), although both differ in the aspects of neural activity that they capture: EEG is sensitive to both radial and tangential sources as well as to deep sources, while MEG is more restrained to the measurement of tangential and superficial neural activity. EEG responses to continuous speech have shown an early subcortical contribution, at a latency of around 9 ms, in agreement with MEG measurements in response to short speech tokens, whereas MEG responses to continuous speech have not yet revealed such an early component. Here we analyze MEG responses to long segments of continuous speech. We find an early subcortical response at a latency of 9 ms, followed by later right-lateralized cortical activities at delays of 20 - 57 ms as well as potential subcortical activities. Our results show that the early subcortical component of the FFR to continuous speech can be measured from MEG, and that its latency agrees with that measured with EEG. They furthermore show that the early subcortical component is temporally well separated from later cortical contributions, enabling an independent assessment of both components towards further aspects of speech processing.
Integrated multi-approaches reveal unique metabolic mechanisms of Vestimentifera to adapt to deep-sea hydrothermal vents
Authors: Sun Qinglei , Yuan Zihao , Sun Yuanyuan , Sun Li 
Published: June 2023

AbstractVestimentiferans (Siboglinidae, Polychaeta) thrive in deep-sea hydrothermal vents and depend on chemosynthetic symbiosis for nutrition. Currently, the central carbon metabolisms, especially the sugar synthesis pathways, of vestimentiferans remain obscure. In this study, the genome of the vestimentiferanArcovestia ivanoviwas obtained. Comparative genomics revealed that, unlike other Polychaeta, vestimentiferans possessed trehaloneogenesis and lacked gluconeogenesis. Transcriptome and metabolome detected the expression of trehalose-6-phosphate synthase (TPS), the key enzyme of trehaloneogenesis, and trehalose in vestimentiferan tissues, especially trophosome, suggesting the possibility of trehalose as the main blood sugar in vestimentiferans. Vestimentiferan TPS was most closely related to arthropod TPS and may be transferred from arthropods via transposons that existed in high densities around the vestimentiferan and arthropod TPS loci. Electron microscopy observed vestimentiferan symbionts with packed glycogen granules. Consistently, glycogen biosynthesis was present in vestimentiferan symbionts but absent in other Siboglinidae symbionts. Together this study revealed that vestimentiferans have evolved unique metabolic mechanisms to adapt to hydrothermal vents by utilizing trehaloneogenesis as the major sugar-synthesizing pathway, which produces trehalose to facilitate tolerance of the stresses (such as high temperature and H2S) of the vents. This study also indicated a critical role of bacterial glycogen biosynthesis in the highly efficient symbiont-vestimentiferan cooperation.
Quality management adoption and management accounting change in a sub-Saharan African firm
Authors: Teklay Belaynesh , Bobe Belete Jember 
Published: June 2023

PurposeIn this study, the authors investigate how institutions influence the adoption and implementation of a quality management practice (QMP) that was originally developed for Western developed countries but is being used in sub-Saharan African firms. The authors’ aim is to contribute to the literature on how local and broader institutions in sub-Saharan African firms impact the adoption of QMP (specifically ISO 9001:2015) and how the firm's situated rationalities shape the associated change in management accounting practices.Design/methodology/approachThe authors applied the extended Burns and Scapens framework and employed a case study research approach. The authors collected empirical data through semi-structured interviews and secondary sources and used direct content analysis to analyse the data.FindingsThe authors’ findings suggest that although personal values and commitments to modernising the business are the main drivers of change, the continued dominance of traditional accounting logic restricts the necessary change in management accounting to support effective QMP implementation.Practical implicationsThis study emphasises the importance of aligning institutional logics to fully realise the benefits of new strategies and identifies technical competencies, access to information and communication technology, and clarity about the role of management accounting in modernising management practices as critical success factors.Originality/valueThis study is original in that it provides insights into the impact of contextual factors in less developed countries on institutionalising QMP and management accounting change, demonstrating the importance of aligning management accounting change with proposed organisational strategies to fully realise their benefits.
Ensuring student-centered value with skills-denominated credentials
Authors: Thorne Kacey , DeMark Sarah , Heath Tyson , Young Kristian 
Published: June 2023

PurposeThe global labor market has been upended and a new landscape has emerged. New models for ensuring the value and relevance of post-secondary education are needed. Learners need better understanding of the value and relevancy which the education provides and more immediate return on the educational investment. Education providers must ensure the relevance of the credentials. Employers require transparency into skills an individual possesses based on the credentials they hold. New models are needed to guide an understanding of credentials so that all have equitable pathways to opportunity. This paper aims to discuss the aforementioned objectives.Design/methodology/approachThe authors in this paper discuss how Western Governors University implemented a Unified Credential Framework (UCF) for ensuring credentials are relevant, verified, transparent and portable. The UCF is predicated on the use of skills as an underlying foundation.FindingsUsing a structured theory for understanding skills and micro-credentials creates more transparency into what post-secondary credentials represent, and the value they hold for individuals, employers and education providers.Research limitations/implicationsThis paper represents a use case where the proposed solution is still emergent. Additional research is warranted as longitudinal data become available on student outcomes and impacts.Originality/valueThis paper presents a model that any organization can implement for clearer line of sight into the value and relevance of post-secondary credentials.
Political environment, employee tenure security and firm performance in middle-income economies
Authors: Boamah Nicholas Addai , Ofori-Yeboah Francis , Appiah Kingsley Opoku 
Published: June 2023

PurposeThe study investigates the effect of political instability and employee tenure security on the performance of firms in middle-income economies (MIEs) after controlling for the influence of corruption, international quality certification, external auditor services and firm age. It examines whether ownership and sector effects matter in the explored relationships.Design/methodology/approachThe study adopts the generalized method of moments estimator and collects firm-level cross-sectional data from 77 MIEs.FindingsThe evidence shows that political uncertainty, employee tenure security and firm age negatively impact firm performance. Also, external quality assurance mainly improves firm performance. Additionally, foreign-owned firms benefit from corruption more than their domestic counterparts. Moreover, there are ownership and sector effects in the firm performance drivers.Practical implicationsThe findings suggest the need for MIE firm managers to implement policies and programs to improve permanent employees' efficiency, commitment and honesty. Policy makers and political actors must work toward a stable political environment in MIEs. The policy must also focus on at least minimizing corruption.Originality/valueThe study shows the contributions of employee tenure security, political instability and corruption to the performance of MIE firms. It documents sector and ownership effects in the factors influencing firm performance.
Influence of the relationship between logistics outsourcing partners on logistics performance: focusing on logistics management in crisis situations
Authors: Lee Changjoon , Ha Young-Kyou 
Published: June 2023

Purpose
This study aims to empirically analyze how the quality of alternatives influences the commitment level in the relationships between companies in supply chains. It also studies how this ultimately influences the associated satisfaction level and logistics performance.

Design/methodology/approach
For this purpose, the authors adopted an extended investment model based on interdependence theory. The authors explored the relationships between logistics outsourcing partners based on the components of the investment model. To examine the correlations between variables, the authors surveyed workers in domestic supply chain–related departments and used a total of 300 valid questionnaires for statistical analysis. The hypotheses were verified through structural equation modeling using SPSS 18.0 and AMOS 18.0.

Findings
The quality of alternatives had a positive influence on the commitment level. Additionally, the commitment level had a positive influence on the satisfaction level but did not have a significant influence on logistics performance. Finally, the satisfaction level exhibited a proportional relationship with logistics performance.

Research limitations/implications
First, this study examined the effects of the relationships between supply chain parties and psychological factors on logistics outsourcing. Second, this study applied the investment model to a logistics outsourcing-related topic. Finally, under the COVID-19 and the trade war, this study is significant as it shows that the existing commonly accepted hypotheses can be overturned.

Originality/value
This study differs from other studies in that it applied the investment model to a logistics outsourcing-related topic.