bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness and cultural adaptations of psychological interventions for eating disorders in East Asia: A systematic scoping review
Authors: Yim See Heng , Schmidt Ulrike 
Published: September 2023

AbstractObjectiveThere has been no review on eating disorder‐focused psychological interventions in East Asia. The aims of this systematic scoping review were to summarize existing and forthcoming studies and to synthesize the cultural adaptations and effectiveness of the interventions identified.MethodFive databases (PubMed, Embase, Global Health, Medline, PsychInfo) and seven trial registries were searched. Studies examining eating disorder (ED)‐focused psychological interventions in East Asia were included. Narrative synthesis was used for the analysis.ResultsEighteen published studies and 14 ongoing/completed but unpublished studies were included. Most published studies were uncontrolled and five were feasibility studies. Among the ongoing studies, 71% are randomized controlled trials. Cognitive therapies were the main approach used, including individual cognitive behavioral therapy (CBT), internet CBT, group CBT, guided self‐help, and cognitive remediation therapy. Cultural adaptations were mostly related to language, communication style and tailoring the dietary requirements to local diets. Interventions were shortened to increase acceptability and reduce financial and time burden to patients. Overall, studies showed good acceptability, completion rates and positive effects on ED symptoms (indicated by moderate to large effect sizes or statistical significance).DiscussionStudies were underpowered and uncontrolled, thus precluding meaningful interpretations of effectiveness to be made. However, the psychological interventions were acceptable and showed promise in delivery. Digital and group interventions seemed to be the most feasible given barriers in the local health systems. More controlled studies, as well as studies on children and adolescents, are needed in future.Public significanceThis is the first systematic scoping review examining psychological interventions for eating disorders in East Asia. Research in eating disorders has largely focused on White people and in Western countries. This review will be helpful for clinicians and researchers to understand the current state of the field through a non‐Eurocentric lens, to identify gaps and plan future research.
Detection of transthyretin amyloid cardiomyopathy by automated data extraction from electronic health records
Authors: Moya Ana , Oeste Clara L. , Beles Monika , Verstreken Sofie , Dierckx Riet , Heggermont Ward , Bartunek Jozef , Bogaerts Eline , Masuy Imke , Hens Dries , Bertolone Dario , Vanderheyden Marc 
Published: September 2023

AbstractAimsTransthyretin amyloid cardiomyopathy (ATTR‐CM), a progressive and fatal cardiomyopathy, is frequently misdiagnosed or entails diagnostic delays, hindering patients from timely treatment. This study aimed to generate a systematic framework based on data from electronic health records (EHRs) to assess patients with ATTR‐CM in a real‐world population of heart failure (HF) patients. Predictive factors or combinations of predictive factors related to ATTR‐CM in a European population were also assessed.Methods and resultsRetrospective unstructured and semi‐structured data from EHRs of patients from OLV Hospital Aalst, Belgium (2012–20), were processed using natural language processing (NLP) to generate an Observational Medical Outcomes Partnership Common Data Model database. NLP model performance was assessed on a random subset of EHRs by comparing algorithm outputs to a physician‐generated standard (using precision, recall, and their harmonic mean, or F1‐score). Of the 3127 HF patients, 103 potentially had ATTR‐CM (age 78 ± 9 years; male 55%; ejection fraction of 48% ± 16). The mean diagnostic delay between HF and ATTR‐CM diagnosis was 1.8 years. Besides HF and cardiomyopathy‐related phenotypes, the strongest cardiac predictor was atrial fibrillation (AF; 72% in ATTR‐CM vs. 60% in non‐ATTR‐CM, P = 0.02), whereas the strongest non‐cardiac predictor was carpal tunnel syndrome (21% in ATTR‐CM vs. 3% in non‐ATTR‐CM, P < 0.001). The strongest combination predictor was AF, joint disorders, and HF with preserved ejection fraction (29% in ATTR‐CM vs. 18% in non‐ATTR‐CM: odds ratio = 2.03, 95% confidence interval = 1.28–3.22).ConclusionsNot only well‐known variables associated with ATTR‐CM but also unique combinations of cardiac and non‐cardiac phenotypes are able to predict ATTR‐CM in a real‐world HF population, aiding in early identification of ATTR‐CM patients.
Phenotype, outcomes and natural history of early‐stage non‐ischaemic cardiomyopathy
Authors: Hammersley Daniel J. , Jones Richard E. , Owen Ruth , Mach Lukas , Lota Amrit S. , Khalique Zohya , De Marvao Antonio , Androulakis Emmanuel , Hatipoglu Suzan , Gulati Ankur , Reddy Rohin K. , Yoon Won Young , Talukder Suprateeka , Shah Riya , Baruah Resham , Guha Kaushik , Pantazis Antonis , Baksi A. John , Gregson John , Cleland John G.F. , Tayal Upasana , Pennell Dudley J. , Ware James S. , Halliday Brian P. , Prasad Sanjay K. 
Published: September 2023

AbstractAimsTo characterize the phenotype, clinical outcomes and rate of disease progression in patients with early‐stage non‐ischaemic cardiomyopathy (early‐NICM).Methods and resultsWe conducted a prospective observational cohort study of patients with early‐NICM assessed by late gadolinium enhancement cardiovascular magnetic resonance (CMR). Cases were classified into the following subgroups: isolated left ventricular dilatation (early‐NICM H−/D+), non‐dilated left ventricular cardiomyopathy (early‐NICM H+/D−), or early dilated cardiomyopathy (early‐NICM H+/D+). Clinical follow‐up for major adverse cardiovascular events (MACE) included non‐fatal life‐threatening arrhythmia, unplanned cardiovascular hospitalization or cardiovascular death. A subset of patients (n = 119) underwent a second CMR to assess changes in cardiac structure and function. Of 254 patients with early‐NICM (median age 46 years [interquartile range 36–58], 94 [37%] women, median left ventricular ejection fraction [LVEF] 55% [52–59]), myocardial fibrosis was present in 65 (26%). There was no difference in the prevalence of fibrosis between subgroups (p = 0.90), however fibrosis mass was lowest in early‐NICM H−/D+, higher in early‐NICM H+/D− and highest in early‐NICM H+/D+ (p = 0.03). Over a median follow‐up of 7.9 (5.5–10.0) years, 28 patients (11%) experienced MACE. Non‐sustained ventricular tachycardia (hazard ratio [HR] 5.1, 95% confidence interval [CI] 2.36–11.00, p < 0.001), myocardial fibrosis (HR 3.77, 95% CI 1.73–8.20, p < 0.001) and diabetes mellitus (HR 5.12, 95% CI 1.73–15.18, p = 0.003) were associated with MACE in a multivariable model. Only 8% of patients progressed from early‐NICM to dilated cardiomyopathy with LVEF <50% over a median of 16 (11–34) months.ConclusionEarly‐NICM is not benign. Fibrosis develops early in the phenotypic course. In‐depth characterization enhances risk stratification and might aid clinical management.
Multiobjective optimization allocation of multi‐skilled workers considering the skill heterogeneity and time‐varying effects in unit brake production lines
Authors: Zeng Huiqin , Nie Sen 
Published: September 2023

AbstractThe optimal allocation of multi‐skilled workers in labor‐intensive industries can improve production capacity and reduce production costs. In actual production, the efficiency of workers will change with time due to their proficiency, fatigue, and other effects. In this article, we attempt to solve the problem of multi‐skilled workers allocation in unit brake production lines considering the heterogeneity of skills and time‐varying effects. A nonlinear mixed‐integer programming model is established, which fully considers the impact of worker efficiency due to proficiency, fatigue, and multi‐task rest recovery. The product production cycle and worker cost are the two objectives of the optimization solution. An enhanced NSGA‐II algorithm that combines the improved NSGA‐II algorithm and the variable neighborhood search (VNS) algorithm is used to solve the multiobjective optimization problem. Finally, the weighted ideal point method is used to obtain the Pareto optimal solution. The application case of a unit brake production is considered to evaluate the proposed model. The results indicate that the time cost and salary cost of workers are reduced by 8.03% and 18.91% compared with the original scheduling. The scheduling model considering learning, fatigue and recovery factors is more suitable for the actual production situation, ensuring the completion time and reducing the labor cost.
EWM: An entropy‐based framework for estimating energy consumption of edge servers
Authors: Li Guangxu , Li Junke 
Published: September 2023

AbstractIn mobile edge computing (MEC), accurately predicting and monitoring the energy consumption of edge servers is a key challenge in achieving green computing. The importance of solving this problem is that it can help optimize the energy usage in data centers and thus reduce the carbon emission of MEC. To this end, we propose an innovative entropy‐based power modeling framework called entropy weighted model (EWM). The EWM framework weights and combines classical prediction models by analyzing the major components of a server and selecting appropriate parameters. We validate the performance of EWM using real server power and performance counter data and compare it with other classical prediction models by Friedman test. The results show that EWM outperforms other classical prediction models in all test datasets. This result validates the significant advantages of our EWM framework in solving the critical problem of edge server power prediction, and provides an effective tool for achieving data center energy optimization and promoting green computing, resulting in a highly general and accurate prediction model.
Shake table tests to compare the seismic response of concrete frames with conventional and high‐strength reinforcement
Authors: Chin Chih‐Hsuan , Cheng Min‐Yuan , Lepage Andrés , Lequesne Rémy D. 
Published: September 2023

AbstractReported test results suggest reinforcement grade can have an important effect on the seismic displacement demands of reinforced concrete (RC) structures. Two one‐story one‐bay RC frames (Specimens C1 and H1) were mounted in parallel on the NCREE‐Taiwan shake table and simultaneously subjected to 16 base motions, each representing a horizontal component of recorded earthquakes. The dynamic tests were followed by quasi‐static large‐amplitude cyclic testing. The specimens had the same nominal dimensions and base shear strengths with longitudinal reinforcement that was Grade 60 (60 ksi [420 MPa]) in C1 and Grade 100 (100 ksi [690 MPa]) in H1. Maximum drifts of H1 were 1.3 to 2.3 times larger than for C1. The lateral stiffness of H1 was consistently lower than C1, with stiffness ratios (H1 to C1) ranging from 0.78 after Run 1 to 0.45 after Run 16. Drift estimates using stiffness values based on gross‐section properties provided a reasonable upper bound for C1 but were unconservative for H1. Drift estimates based on the secant‐to‐yield stiffnesses, which were inversely proportional to reinforcement grade, provided an upper bound for both specimens. Preliminary recommendations are made for accounting for these effects in design.
Seismic behavior of a fully tempered insulating glass curtain wall system under various loading protocols
Authors: Ji Xiaodong , Zhuang Yuncheng , Lim Wanhui , Qu Zhe 
Published: September 2023

AbstractThis paper investigates the seismic behavior of a glass curtain wall system under various loading scenarios. Experimental set‐ups and approaches were developed to test full‐scale fully tempered (FT) insulating glass curtain wall systems subjected to three loading protocols: quasi‐static in‐plane loading, dynamic in‐plane loading, and dynamic coupled in‐plane and out‐of‐plane loading. A refined finite element (FE) model was developed to understand the behavior of the system. The average drift associated with glass cracking and fallout was found to be nearly identical for quasi‐static and dynamic in‐plane loading, indicating that in‐plane floor accelerations exerted marginal influence on the failure of the glass curtain walls. Bi‐directional loading led to an approximately 30% decrease in the glass fallout drift compared with in‐plane loading. This is because the out‐of‐plane drift placed an increased stress demand on the glass panel, as indicated by the FE analysis. Both the experimental tests and FE analysis revealed that the ASCE 7–16 formula, which is used to calculate the drift of contact between the glass and frame, is nonconservative as it does not consider the deformation of the surrounding frame and the friction between the gasket and the glass. The failure mechanism of the glass panel was caused by the stress concentrations at the diagonal corners due to glass‐to‐frame contact. The FE analysis indicated that the interactional effect among different glass units was negligible, and the glass panels exhibited a similar stress state regardless of their positions.
Physics‐based preconditioning of Jacobian‐free Newton–Krylov solver for Navier–Stokes equations using nodal integral method
Authors: Ahmed Nadeem , Singh Suneet , Kumar Niteen 
Published: September 2023

AbstractThe nodal integral methods (NIMs) have found widespread use in the nuclear industry for neutron transport problems due to their high accuracy. However, despite considerable development, these methods have limited acceptability among the fluid flow community. One major drawback of these methods is the lack of robust and efficient nonlinear solvers for the algebraic equations resulting from discretization. Since its inception, several modifications have been made to make NIMs more agile, efficient, and accurate. Modified nodal integral method (MNIM) and modified MNIM (M2NIM) are the two most recent and efficient versions of the NIM for fluid flow problems. M2NIM modifies the MNIM by replacing the current time convective velocity with the previous time convective velocity, leading to faster convergence albeit with reduced accuracy. This work proposes a preconditioned Jacobian‐free Newton–Krylov approach for solving the Navier–Stokes equation using MNIM. The Krylov solvers do not generally work well without an appropriate preconditioner. Therefore, M2NIM is used here as a preconditioner to accelerate the solution of MNIM. Due to pressure–velocity coupling in the Navier–Stokes equation, developing a quality preconditioner for these equations needs significant effort. The momentum equation is solved using the time‐splitting alternate direction implicit method. The velocities obtained from the solution are then used to solve the pressure Poisson equation. The computational results for the Navier–Stokes equation are presented to underscore the advantages of the developed algorithm.
Design, Synthesis and Biological Evaluation of Simplified Analogues of the Major Corn Strigolactones, Zealactone and Zeapyranolactone
Authors: Yoshimura Masahiko , Dieckmann Michael , Lumbroso Alexandre , Fonné‐Pfister Raymonde , Screpanti Claudio , Hermann Katrin , Rendine Stefano , Quinodoz Pierre , De Mesmaeker Alain 
Published: September 2023

AbstractStrigolactones are one of the phytohormones, which have multiple activities on plant growth and development. Since these strigolactone activities are highly associated with crop yield, use of strigolactone could be a promising technology in modern sustainable agriculture. The major strigolactones in corn root exudates have been identified as zealactone 1a/b and zeapyranolactone. We recently disclosed the first total synthesis of zealactone 1a/b together with its biological activity in corn. Herein, we describe the design and synthesis of simplified analogues of both corn‐derived strigolactones with their bioavailability in soil and their biological activities. These compounds would be potential leads for the development of synthetic strigolactones for the agronomical use in a more sustainable crop production.
Synthesis and Evaluation of Novel 5‐O‐(4‐C‐Aminoalkyl‐β‐D‐ribofuranosyl) Apramycin Derivatives for the Inhibition of Gram‐Negative Pathogens Carrying the Aminoglycoside Phosphotransferase(3′)‐Ia Resistance Determinant
Authors: Lubriks Dmitrijs , Haldimann Klara , Kiliç Fatmanur , Hartmann Maximilian , Böttger Erik C. , Hobbie Sven N. , Suna Edgars , Crich David 
Published: September 2023

AbstractWe report the synthesis and evaluation of two new apramycin 5‐O‐β‐d‐ribofuranosides, or apralogs, carrying aminoalkyl branches at the ribofuranose 4‐position. This novel modification conveys excellent activity for the inhibition of protein synthesis by wild‐type bacterial ribosomes and correspondingly high antibacterial activity against several Gram‐negative pathogens. Notably, these new modifications overcome the reduction of antibacterial activity in other 2‐deoxystreptamine‐type aminoglycosides carrying a 5‐O‐ribofuranosyl moiety when challenged by the presence of an aminoglycoside phosphotransferase enzyme capable of acting on the ribose 5‐position.
Contour integration for the view factor calculation between two rectangular surfaces
Authors: Camaraza‐Medina Yanan , Hernandez‐Guerrero Abel , Luviano‐Ortiz J. Luis 
Published: September 2023

AbstractThe calculation of the view factor is an important consideration in radiative heat transfer analysis. Thermal engineering requires the view factor calculations between complex geometries containing parallel and inclined surfaces. There is currently no analytic formula available for this, so the summation rule (SR) must be used. However, when complex geometries are analyzed, processing SR becomes a very intensive task. Therefore, the present study aims to exploit vector calculus to develop a formula for calculating the view factors for radiative heat transfer from any two rectangular oblique or parallel surfaces. The exact solution obtained by means of the contour integration was compared with the numerical integration of the quadruple integral using the multiple Simpson's rule 1/3 with five intervals (MSR) and the summation rule via the Hamilton–Morgan solution (HMS). The lack of similar precedents in the literature reinforces the scientific and practical nature of the proposed method.
Effect of low‐molecular‐weight heparin on placenta‐mediated fetal growth restriction in a tertiary referral hospital: A 7‐year retrospective cohort study
Authors: Xu Jinfeng , Tang Yuxin , Peng Bing , Zhang Wei‐Hong , Wang Xiaodong 
Published: September 2023

AbstractObjectiveTo investigate the effect of low‐molecular‐weight heparin (LMWH) on placenta‐mediated fetal growth restriction (FGR).MethodsA cohort of 570 pregnant women diagnosed with placenta‐mediated FGR were enrolled from January 1, 2015 through to December 31, 2021. A birth database, including demographic data, antenatal complications, and detailed delivery and newborn data, was created to collect variables from the Hospital Information System (HIS) Database. The unique personal registration number, assigned to each patient on first registration with HIS in the West China Second University Hospital, was used to link these patients. LMWH use was defined as at least 1‐week prescription from diagnosis of placenta‐mediated FGR. Pregnant women received LMWH (Enoxaparin 4000 IU/day) by self‐administered subcutaneous injection only when they agreed and signed informed consent. Primary outcome was intrauterine fetal death after 20 weeks of pregnancy. Secondary outcomes included preterm birth (PB), Apgar score less than 7 at 1 min, admission to neonatal intensive care unit (NICU), and birth weight. Logistic regression analysis was conducted to compute adjusted odds ratio (aOR) with 95% confidence intervals (CI) for outcomes.ResultsAfter controlling for confounders, LMWH use was associated with a decreased risk of intrauterine fetal death (aOR 2.49, 95% CI 1.35–4.57, P = 0.003), PB before 37 weeks of pregnancy (aOR 3.35, 95% CI 2.14–5.23, P < 0.001), PB before 34 weeks of pregnancy (aOR 2.25, 95% CI 1.36–3.74, P = 0.002), Apgar score less than 7 at 1 min (aOR 2.25, 95% CI 1.36–3.74, P = 0.002), NICU admission (aOR 2.29, 95% CI 1.48–3.55, P < 0.001). Using LMWH increased the mean birth weight in PB before 32 weeks of pregnancy (mean ± standard deviation [SD] 1126.4 ± 520.0 g, P = 0.020), PB before 37 weeks of pregnancy (mean ± SD 1563.9 ± 502.7 g, P = 0.019), early‐onset FGR (mean ± SD 2125.2 ± 665.7 g, P < 0.001), late‐onset FGR (mean ± SD 2343.4 ± 507.9, P < 0.001), and non‐severe FGR (mean ± SD 2231.1 ± 607.2 g, P < 0.001).ConclusionUse of LMWH can significantly improve the fetal and neonatal outcomes among pregnant women with placenta‐mediated FGR, particularly reducing the risk of intrauterine fetal death.
Cytocompatibility, antibacterial, and corrosion properties of chitosan/polymethacrylates and chitosan/poly(4‐vinylpyridine) smart coatings, electrophoretically deposited on nanosilver‐decorated titania nanotubes
Authors: Pawłowski Łukasz , Bartmański Michał , Ronowska Anna , Banach‐Kopeć Adrianna , Mania Szymon , Cieślik Bartłomiej Michał , Mielewczyk‐Gryń Aleksandra , Karczewski Jakub , Zieliński Andrzej 
Published: September 2023

AbstractThe development of novel implants subjected to surface modification to achieve high osteointegration properties at simultaneous antimicrobial activity is a highly current problem. This study involved different surface treatments of titanium surface, mainly by electrochemical oxidation to produce a nanotubular oxide layer (TNTs), a subsequent electrochemical reduction of silver nitrate and decoration of a nanotubular surface with silver nanoparticles (AgNPs), and finally electrophoretic deposition (EPD) of a composite of chitosan (CS) and either polymethacrylate‐based copolymer Eudragit E 100 (EE100) or poly(4‐vinylpyridine) (P4VP) coating. The effects of each stage of this multi‐step modification were examined in terms of morphology, roughness, wettability, corrosion resistance, coating‐substrate adhesion, antibacterial properties, and osteoblast cell adhesion and proliferation. The results showed that the titanium surface formed nanotubes (inner diameter of 97 ± 12 nm, length of 342 ± 36 nm) subsequently covered with silver nanoparticles (with a diameter of 88 ± 8 nm). Further, the silver‐decorated nanotubes were tightly coated with biopolymer films. Most of the applied modifications increased both the roughness and the surface contact angle of the samples. The deposition of biopolymer coatings resulted in reduced burst release of silver. The coated samples revealed potent antimicrobial activity against both Gram‐positive and Gram‐negative bacteria. Total elimination (99.9%) of E. coli was recorded for a sample with CS/P4VP coating. Cytotoxicity results using hFOB 1.19, a human osteoblast cell line, showed that after 3 days the tested modifications did not affect the cellular growth according to the titanium control. The proposed innovative multilayer antibacterial coatings can be successful for titanium implants as effective postoperative anti‐inflammation protection.