bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment pattern and health care resource utilization for Taiwanese patients with migraine: a population-based study
Authors: Wang Yen-Feng , Wang Shuu-Jiun , Huang Yao Hsien , Chen Yung-Tai , Yen Yu-Chun , Shia Ben-Chang , Tsai Ching-Wen , Chan Hoi-Fong , Panni Tommaso , Dell’Agnello Grazia 
Published: August 2023

ObjectivesGiven the substantial disease burden, appropriate and effective management of migraine is a public health priority. To gain insights into real-world migraine management practices in Taiwan, current treatment patterns, costs, and health care resource use were assessed.MethodsThis was a retrospective, longitudinal study using the Taiwan National Health Insurance Research Database. Included patients had an initial diagnosis of migraine (defined using International Classification of Diseases codes) between 1 January 2013 and 31 December 2017. Data analyzed included demographics; the use, number, and type of acute and preventive medications; and drug and medical services costs. Data were stratified according to migraine type (chronic [CM] or episodic [EM] migraine).ResultsA total of 312,718 patients were included in the analyses: 53,992 (17.3%) had CM and 258,726 (82.7%) had EM. Most patients (81.7%) had used acute and/or preventive medications; acute medications used more frequently than preventive medications (78.0% vs. 20.2%). Acute medications were used by 81.6 and 77.3% of patients with CM and EM, respectively. Commonly used acute medications were acetaminophen (68.8%), ergots (49.4%), and non-steroidal anti-inflammatory drugs (38.4%); the use of triptans (6.0%), tramadol (3.1%), and other opioids (0.2%) was less common. A total of 28.6 and 18.5% of patients with CM and EM, respectively, used preventive medications. Flunarizine (68.9%), propranolol (40.7%), and topiramate (16.0%) were the most commonly used preventive medications. Most patients had used 1–2 acute or preventive medications, with the use of ≥3 acute or preventive medications more common in patients with CM than EM. Average total medical costper annumwas 4,169 New Taiwan Dollars (NTDs) per CM patient and 2,928 NTDs per EM patient, with CM patients having higher costs associated with medical service utilization and acute medication use.ConclusionThese real-world data suggest unmet needs for Taiwanese patients with migraine, including under-utilization of preventive medications and greater costs and health care resource use for patients with CM versus EM. These findings provide important information on treatment patterns, cost, and health care resource use for patients with migraine in Taiwan.
Choriocarcinoma complicated with intra-abdominal and intrapleural hemorrhage in pregnancy – case report
Authors: Jaz Kamila , Miedziarek Cezary , Piasek Ewa , Florek Artur , Nowak-Markwitz Ewa , Zaborowski Mikołaj Piotr 
Published: August 2023

BackgroundChoriocarcinoma is a rare neoplasm, exceptionally uncommon during an ongoing pregnancy. The disease often has a metastatic character, causing severe symptoms from various anatomic sites like the lungs, central nervous system, vagina, pelvis, or liver. Due to the condition’s rarity, evidence on how to treat the choriocarcinoma originating during pregnancy remains scarce.Case presentationHere, we present a case of a patient who developed choriocarcinoma before the 29th week of gestation. The neoplasm had a metastatic character, resulting in hemorrhage complicated by a hypovolemic shock. The patient underwent an emergency cesarean section and several surgeries to stop the massive hemorrhage. The treatment of the choriocarcinoma included chemotherapy with methotrexate followed by an EMA-CO regimen. The patient had a complete response to the therapy. The neonate suffered from complications related to prematurity.ConclusionMetastatic choriocarcinoma can be a diagnostic and therapeutic challenge during ongoing pregnancy. Treatment of the disease can be associated with severe complications, but a complete response to chemotherapy is possible with a favorable long-term prognosis.
Antitumor effect of anti-vascular therapy with STING agonist depends on the tumor microenvironment context
Authors: Czapla Justyna , Drzyzga Alina , Matuszczak Sybilla , Cichoń Tomasz , Rusin Marek , Jarosz-Biej Magdalena , Pilny Ewelina , Smolarczyk Ryszard 
Published: August 2023

IntroductionTargeting tumor vasculature is an efficient weapon to fight against cancer; however, activation of alternative pathways to rebuild the disrupted vasculature leads to rapid tumor regrowth. Immunotherapy that exploits host immune cells to elicit and sustain potent antitumor response has emerged as one of the most promising tools for cancer treatment, yet many treatments fail due to developed resistance mechanisms. Therefore, our aim was to examine whether combination of immunotherapy and anti-vascular treatment will succeed in poorly immunogenic, difficult-to-treat melanoma and triple-negative breast tumor models.MethodsOur study was performed on B16-F10 melanoma and 4T1 breast tumor murine models. Mice were treated with the stimulator of interferon genes (STING) pathway agonist (cGAMP) and vascular disrupting agent combretastatin A4 phosphate (CA4P). Tumor growth was monitored. The tumor microenvironment (TME) was comprehensively investigated using multiplex immunofluorescence and flow cytometry. We also examined if such designed therapy sensitizes investigated tumor models to an immune checkpoint inhibitor (anti-PD-1).ResultsThe use of STING agonist cGAMP as monotherapy was insufficient to effectively inhibit tumor growth due to low levels of STING protein in 4T1 tumors. However, when additionally combined with an anti-vascular agent, a significant therapeutic effect was obtained. In this model, the obtained effect was related to the TME polarization and the stimulation of the innate immune response, especially activation of NK cells. Combination therapy was unable to activate CD8+ T cells. Due to the lack of PD-1 upregulation, no improved therapeutic effect was observed when additionally combined with the anti-PD-1 inhibitor. In B16-F10 tumors, highly abundant in STING protein, cGAMP as monotherapy was sufficient to induce potent antitumor response. In this model, the therapeutic effect was due to the infiltration of the TME with activated NK cells. cGAMP also caused the infiltration of CD8+PD-1+ T cells into the TME; hence, additional benefits of using the PD-1 inhibitor were observed.ConclusionThe study provides preclinical evidence for a great influence of the TME on the outcome of applied therapy, including immune cell contribution and ICI responsiveness. We pointed the need of careful TME screening prior to antitumor treatments to achieve satisfactory results.
Calmodulin mutations affecting Gly114 impair binding to the NaV1.5 IQ-domain
Authors: Brohus Malene , Busuioc Ana-Octavia , Wimmer Reinhard , Nyegaard Mette , Overgaard Michael Toft 
Published: August 2023

Missense variants in CALM genes encoding the Ca2+-binding protein calmodulin (CaM) cause severe cardiac arrhythmias. The disease mechanisms have been attributed to dysregulation of RyR2, for Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) and/or CaV1.2, for Long-QT Syndrome (LQTS). Recently, a novel CALM2 variant, G114R, was identified in a mother and two of her four children, all of whom died suddenly while asleep at a young age. The G114R variant impairs closure of CaV1.2 and RyR2, consistent with a CPVT and/or mild LQTS phenotype. However, the children carrying the CALM2 G114R variant displayed a phenotype commonly observed with variants in NaV1.5, i.e., Brugada Syndrome (BrS) or LQT3, where death while asleep is a common feature. We therefore hypothesized that the G114R variant specifically would interfere with NaV1.5 binding. Here, we demonstrate that CaM binding to the NaV1.5 IQ-domain is severely impaired for two CaM variants G114R and G114W. The impact was most severe at low and intermediate Ca2+ concentrations (up to 4 µM) resulting in more than a 50-fold reduction in NaV1.5 binding affinity, and a smaller 1.5 to 11-fold reduction at high Ca2+ concentrations (25–400 µM). In contrast, the arrhythmogenic CaM-N98S variant only induced a 1.5-fold reduction in NaV1.5 binding and only at 4 µM Ca2+. A non-arrhythmogenic I10T variant in CaM did not impair NaV1.5 IQ binding. These data suggest that the interaction between NaV1.5 and CaM is decreased with certain CaM variants, which may alter the cardiac sodium current, INa. Overall, these results suggest that the phenotypic spectrum of calmodulinopathies may likely expand to include BrS- and/or LQT3-like traits.
Biplanar quadrature coil for versatile low-field extremity MRI
Authors: Yushchenko Maksym , Choquet Philippe , Salameh Najat , Sarracanie Mathieu 
Published: August 2023

Biplanar magnets offer extended flexibility in MRI, particularly appealing due to unmatched accessibility to the patient. At low field strength (&lt;0.2 T), such geometries could be particularly suitable for interventional settings or purpose-built applications such as musculoskeletal imaging. In the proposed work, we present a dual-channel, biplanar coil array for low-field MRI featuring almost fully open access when sited in a biplanar magnet. The proposed detector relies on the assembly of two orthogonal biplanar coils (single transmit channel, two receive channels in quadrature) respectively interfaced with custom inductive couplers. Simulations of the B1 field in each element were performed before the quadrature coil was built and used at ∼ 0.1 T (4.33 MHz). Once assembled, the best performance in our setup was achieved in undermatched conditions in place of conventional 50-Ω matching. Phantom images display the extended coverage of the quadrature coil, with similar SNR from each individual biplanar coil. The combined images show an expected SNR gain of 2 that confirms good decoupling between the two channels (−36 dB). To the best of our knowledge, the proposed coil represents the first implementation of a biplanar geometry at low field and the first quadrature detection for a biplanar design. The open design and overall good sensitivity of our biplanar design enabled fast and quasi-isotropic 3D imaging with (1.6 × 1.6 × 2.2) mm3 resolution in vivo in human extremities.
Post-healing perceptions and experiences of alcohol withdrawal and life management in men with alcoholic pancreatitis: a qualitative study
Authors: Chen Runpeng , Wang Qinghua , Wang Dongyang , Liu Xinyue , Wang Haiyun , Guo Jiaoyang , Liu Xinghui 
Published: August 2023

IntroductionThe aim of this study was to examine the perceptions and experiences of male patients with alcoholic pancreatitis after healing regarding alcohol withdrawal and life management.MethodsThis study used a qualitative descriptive design, and participants were selected by purposive sampling from two tertiary care hospitals in Shandong Province, China. Semi-structured in-depth interviews were conducted with 18 male patients discharged from the gastroenterology department who had recovered from alcoholic pancreatitis. Colaizzi’s method was used to analyze the interview data, and the findings were reported using COREQ criteria.ResultsBy analyzing the interview data, we summarized five themes, (1) the dilemma of sobriety, (2) role change, (3) illness status, (4) family influence, and (5) life management.ConclusionBy profiling the perceptions and experiences of post-healing alcoholic pancreatitis patients’ alcohol cessation and life management in men, it helps to grasp the details of alcohol cessation and health direction of patients’ home management, which provides more directional guidance to help patients maintain positive and good lifestyle habits and active management awareness, followed by targeted personalized interventions to provide patients with knowledge of disease care and health management.
Factors in cognitive processing of Japanese loanwords by advanced Chinese Japanese-as-a-foreign-language learners
Authors: Geng Yaoyao , Song Qichao , Fei Xiaodong 
Published: August 2023

IntroductionPrevious studies have highlighted the challenges faced by Chinese Japanese-as-a-foreign-language (JFL) learners (whose L2 is English) in acquiring L3 Japanese loanwords. These challenges arise from the linguistic characteristics of loanwords and the limited emphasis on teaching and learning them. However, there is a lack of research on the specific factors that influence the processing of Japanese loanwords among Chinese JFL learners. Significant motivation exists, therefore, to investigate these influencing factors as they provide valuable insight into the integration of phonographic and ideographic language systems, ultimately facilitating future lexical acquisition.MethodsIn this study, an experiment was conducted on 31 Chinese JFL learners to investigate the effects of loanword familiarity, English vocabulary proficiency, English-Japanese phonological similarity, and context on the processing of Japanese loanwords.ResultsData analysis, using a (generalized) linear mixed-effect model, provided the following insights: (1) the processing of Japanese loanwords is influenced by English-Japanese phonological similarity, loanword familiarity, context, and learner English proficiency. Among these four factors, familiarity has the most significant impact on Japanese loanword processing; (2) the effects of context and phonological similarity on the processing of Japanese loanwords are not consistently positive. As learners improve their proficiency in L3 Japanese, they tend to decrease their reliance on English knowledge and instead access loanword representations directly to conceptual representations.DiscussionBased on the findings of this study, a processing model for Japanese loanwords among advanced Chinese JFL learners is proposed. The model emphasizes the critical importance of the characteristics of loanwords, including phonological similarity and familiarity. It is necessary to determine the specific circumstances in which context considerably enhances learner processing ability.
Predictors of referral behaviour and intention amongst physicians in a medical consortium based on the theory of planned behaviour: a cross-sectional study in China
Authors: Zhao Dongbao , Chen Shengliang , Jin Sihui , Chen Lijin , Zheng Caiyun , Wang Xin , Huang Yixiang 
Published: August 2023

IntroductionTo promote patients’ referral across healthcare institutions and integrated care delivery, we identified predictors of physicians’ behaviour and intention to refer patients in a county medical consortium in China on the basis of the theory of planned behaviour (TPB).MethodsThis census-based cross-sectional study was conducted in Yangxi Hospital Group (YHG). All physicians in county hospitals and township health centres were invited to participate. Structural equation modelling was employed to analyse the relationships between referral intention and behaviour and other TPB variables in the group of whole participants and in sub-groups.ResultsIn total, 330 physicians participated in this study. One-third of participants were general practitioners, and half of them were from county hospitals. Referral behaviour of females (χ2 = 20.372, p &lt; 0.001), who had lower education levels (χ2 = 17.859, p = 0.001), lower professional title (χ2 = 14.963, p = 0.005), and lower monthly salary (χ2 = 33.753, p &lt; 0.001) were less frequent than the others. Among them, 116 (35.2%), 108 (32.7%), and 106 (32.1%) respondents reported that they had never referred patients, had referred patients 1–9 times, and had referred patients over 10 times during the past 3 months, respectively. The mean score of referral intention was 4.23/5 (SD = 0.71). In the model with all participants, a stronger referral intention (β = 0.218, 95% CI = 0.080–0.356) was associated with more frequent referral behaviour. The subjective norm (β = 0.703, 95% CI = 0.590–0.817) was the strongest predictor of physicians’ referral intention, followed by perceived behavioural control (β = 0.234, 95% CI = 0.090–0.378). Mediated by referral intention, subjective norms (β = 0.153, p &lt; 0.01) and perceived behavioural control (β = 0.190, p &lt; 0.01) had significant indirect effects on physicians’ referral behaviour. The model with participants in county hospitals showed similar results to the model with all participants. Meanwhile, in the model with participants in township health centres, there were no significant associations between referral behaviour and other TPB constructs.ConclusionPhysicians’ referral behaviour was influenced by intention, subjective norms, and perceived behavioural control in Chinese county hospitals.
Characterization of rumen microbiota in lactating Holstein cows fed molasses versus corn grain at two levels of rumen-degradable protein
Authors: Guduk E. , Hall M. B. , Zanton G. I. , Steinberger A. J. , Weimer P. J. , Suen G. , Weigel K. A. 
Published: August 2023

We evaluated the influence of diets differing in non-fiber carbohydrates and rumen-degradable protein (RDP) levels on changes in the ruminal bacterial populations in lactating Holstein cows. In all, 12 ruminally cannulated cows were assigned to diets with high or low RDP levels. Within each RDP level, molasses was substituted for corn grain at a concentration of 0%, 5.25%, or 10.5% of diet dry matter in a replicated 3 × 3 Latin square design with 28-day periods. Liquid and solid rumen digesta fractions collected at the end of each period underwent 16S rRNA gene sequencing to identify operational taxonomic units and were analyzed for short-chain fatty acids. Protein degradability affected 6 bacterial genera, whereas carbohydrate alteration impacted 13 genera (p &lt; 0.05). Of the 30 genera with the highest relative abundance, 26 differed by digesta fraction (p &lt; 0.05), with Bacteroidetes genera showing a greater abundance in solids and Firmicutes genera demonstrating a greater prevalence in liquids. Regarding relative abundances, with increasing molasses, Succiniclasticum decreased in liquid (p &lt; 0.05), and CF231, YRC22, Clostridium, Desulfovibrio, BF311, and Oscillospira increased in solids (p &lt; 0.05). In contrast, at higher RDP levels, Succiniclasticum increased while YRC22 and Pseudobutyrivibrio decreased in solids (p &lt; 0.05). Genera with abundances found to be correlated with fermentation products in the liquid included Shuttleworthia, Treponema, Lachnospira, and Schwartzia, which typically have lower relative abundances, showing strong positive correlations with molar proportions (mol%) of propionate, butyrate, and valerate (p &lt; 0.05), and negative correlations with pH and acetate mol% (p &lt; 0.05). Fibrobacter was positively correlated with lactate mol% (p &lt; 0.05). Butyrate mol% exhibited a quadratic increase as molasses increased (p = 0.017), and lactate mol% rose with increased RDP levels (p = 0.042). No treatment effects were detected for pH propionate and valerate mol%; however, we observed a tendency (p = 0.075) for a quadratic effect of molasses treatment on the mol% of acetate. These findings substantiate the pivotal role of diet in shaping rumen microbiota and metabolism, elucidating a nuanced relationship between dietary components, bacterial community structure, and metabolic output. This offers a more detailed understanding of rumen function and the potential for high-precision dietary management in lactating cows.
ANALISIS HADITH AHKAM BERBASIS WASIAT WAJIBAH
Authors: Ubaidillah M Hasan 
Published: August 2023

Pada dasarnya, Tuhan menciptakan manusia disertai dengan perasaan senang dan bahagia. Terlebih jika dihadapkan dengan harta, maka perasaan senang dan bahagia tersebut akan semakin bertambah. Akan tetapi, perasaan senang dan bahagia tersebut suatu saat akan pupus manakala manusia memasuki usia lanjut dan tentunya sisa umurnya semakin sedikit. Sekalipun manusia sudah mendekati ajalnya, tetapi mereka masih berkeinginan untuk memberikan harta yang dimilikinya tersebut kepada orang lain yang disenanginya baik karena keturunannya, kerabatnya, dan lain sebagainya. Pengalihan hak kepemilikan harta terhadap orang lain pasca meninggalnya pihak pemilik harta, dimungkinkan melalui jalan waris dan bisa juga karena ada wasiat. Dalam perspektif hukum Islam, baik waris maupun wasiat mendapatkan legalitas formal. Hal ini dikarenakan adanya tabiat atau naluri manusia untuk mengalihkan hartanya kepada orang lain baik anggota keluarganya maupun orang lain yang tidak ada hubungan kekeluargaan demi terpeliharanya harta tersebut disamping juga karena adanya nass-nas shar‘i yang melegitimasinya. Namun, demi kepentingan efektifitas dan efisiensi pembahasan dalam makalah ini, penulis lebih memfokuskan kajiannya terhadap wasiat mulai dari definisi wasiat, hukum berwasiat, berwasiat kepada ahli waris, perkembangan makna wasiat, dan hal-hal lain yang ada kaitannnya dengan pembahasan wasiat.
KONTROVERSI PERAN AKTIF WANITA DALAM URUSAN UMUM (Studi Hadis Kepemimpinan Wanita)
Authors: Kurniawati Nining Rizqi 
Published: August 2023

Abstrak
Hingga saat ini, gagasan untuk menciptakan kesetaraan gender masih menjadi perdebatan. Diantaranya termasuk posisi kepemimpinan wanita yang dianggap tidak pantas. Secara fisik dan kejiwaan, pria dan wanita berbeda. Perbedaan tersebut menjadikan laki-laki sebagai tokoh utama dalam kehidupan bermasyarakat, sehingga dianggap lebih berpotensial menjalankan tugas-tugas kemasyarakatan. Berbeda dengan biologis perempuan yang justru dianggap sebagai kelemahan, yang membatasi ruang geraknya, sehingga dianggap tak mampu mengemban tugas-tugas kemasyarakatan.
Tujuan penelitian ini ialah untuk memahami tentang kepemimpinan wanita dalam hukum Islam berdasarkan hadis tentang kepemimpinan wanita yang di bawakan oleh Abū Bakrah. Dari konteks ini muncul dua pandangan, yakni memperbolehkan dan menolak. Kelompok yang memperbolehkan kepemimpinan wanita berpandangan bahwa hadis tersebut bersifat kontekstual dan berlaku pada waktu tertentu. Sedangkan kelompok yang menolak, berpandangan bahwa hadis tersebut berlaku tidak hanya pada konteks masa lalu, tetapi untuk segala zaman. Untuk mengidentifikasi permasalahan tersebut, penelitian ini menggunakan teknik content analysis (kajian isi) yang bersifat deskriptif, menelaah dan mengkaji isi hadis tentang kepemimpinan wanita yang dibawakan oleh Abū Bakrah. Adapun teknik pengumpulan data menggunakan studi literasi (library research).
Abstract
To this day, the idea of gender equality remains debated. Some include women's leadership positions that are deemed inappropriate. Physically and psychologically, men and women are different. Such differences make men the main character in social life, thus becoming more likely to perform civic duties. In contrast with female biology, which is considered a weakness, which limits her mobility, and which makes her incapable of caring for civic duties.
The purpose of this study is to understand the leadership of women in islamic law based on the hadith of the leadership of women brought to Abū Bakrah. From this context the two views of condoning and refusing are consensual. The group that allows female leadership to view the hadith as contextual and valid at any given time. Whereas those who refuse, the view that the hadith applies not only to the context of the past, but to all time. To identify the issue, the study used a descriptive analysis of content analysis, studying and reviewing the contents of the hadiths on the leadership of women brought by Abū Bakrah. As for data collection techniques using library research studies.