bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated Blood Malondialdehyde Level Contributed to a High Stroke Risk in a Chinese Elderly Population from Rural Areas
Authors: Wan Rong , Su Yuhao , Zhu Meilan , Hu MD. Dongxia , Huang Ying 
Published: February 2023

Abstract
Background: Individuals living in rural areas had higher incidence rate for stroke than their urban counterparts in China. However, few studies investigated on the association between blood malondialdehyde (MDA), an end product of lipid oxidation caused by reactive oxygen species (ROS), and stroke risk in rural population.
Aim: We aimed to investigate whether blood MDA level contributes to a higher stroke risk in a Chinese elderly population from rural areas.
Methods: Data from 2011-2012 of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a national cohort of older adults in China were analyzed. Smooth curve and multivariable correction analysis were used to evaluate the association between blood MDA level and stroke risk in the elderly populations from rural and urban areas respectively.
Results: The median age of all inluded participants (N=1598) was 84 years. The results of smooth curve model revealed a gradual upward trend on association of blood MDA levels with stroke risk in rural participants but not in urban participants. Similarly, the conditional logistic regression analysis suggested a significant association MDA levels with stroke risk in rural participants but not in urban participants after adjustments of related confounding factors (age, gender, current smoker, current drinker, current exercise, BMI and cardiovascular diseases (hypertension, heart disease, atrial fibrillation and diabetes) were made.
Conclusion: Among the elderly population in China, elevated blood MDA levels were associated with increased stroke risk in rural participants but not in urban participants.
Alveolar macrophages polarity switch via α 2 -adrenoceptor activation ameliorates pulmonary inflammation following kidney ischemia reperfusion
Authors: Qin Zhigang , Li jieyu , He Xinhai , Liu Xiangfeng , Yang Ziheng , Xue Zhengwei , Yi Bin , Li Peng , Xu Yueming , Gu Jianteng 
Published: February 2023

Abstract
Purpose: To investigate the anti-inflammatory mechanism of dexmedetomidine (Dex), an α2-adrenoceptor (α2-AR) agonist, on renal ischemia-reperfusion (RIR)-induced acute lung injury (ALI).
Methods: RIR was performed in C57BL/6J mice by bilateral renal pedicles occlusion for 60min and reperfusion for 24h. Mice were pre-treated with or without Dex alone or combined atipamezole (Atip), an α2-AR antagonist. The pulmonary histopathological evaluation, arterial blood gas analysis, cell count and multiple cytokines examination in BALF, global inflammation status assessment in lung tissue and alveolar macrophages phenotype investigation were accomplished. In vitro, the polarity of mice alveolar macrophages (MH-S) treated with serum from normal or RIR mice were indirectly detected by qPCR.
Results: The results indicated that, compared to RIR animal, dexmedetomidine reduced lung injury and significantly promoted macrophage polarization towards an anti-inflammatory M2 phenotype in the pulmonary tissue. Meanwhile, the reduction of inflammatory cell infiltration and pro-inflammatory cytokines levels were observed. In vitro studies confirmed that dexmedetomidine skewed MH-S towards M2 phenotype after stimulation of RIR serum. After administration of the atipamezole, these above effects were abolished.
Conclusion: Dexmedetomidine ameliorates renal ischemia-reperfusion induced ALI through activation of α2-adrenoceptor to skew macrophages towards an anti-inflammatory phenotype to reduce pulmonary global inflammation.
Comparison of hybrid walnut trees growth in an agroforestry system and under forestry condition
Authors: Heim Lucie , Candelier Kevin , Badel Eric , Denaud Louis , Dufour Lydie , Marchal Remy 
Published: February 2023

AbstractThe services provided by agroforestry trees are numerous, especially on the economic front. They help to improve the business model of the farm by diversifying activities and incomes for the farmer. However, agroforestry trees grow in very different conditions than in traditional forests; mainly because of the specific environmental conditions like their higher exposure to wind and light and the strong interactions with annual crops. Moreover, numerous human operations on branches (pruning) and the soil tillage, that can affect the root systems, modify the growing conditions too. Production level and quality such as anatomical, chemical and technological properties of wood coming from agroforestry systems have not yet been investigated. The present study aims to understand how the particular agroforestry growing conditions affect the trees’ development - especially primary and secondary growths. A comparative study on the growing kinetics in height and diameter, from 1995 to 2014 of hybrid walnut trees in an agroforestry plot and in a forest control plot, was performed at the Restinclières experimental Platform, in France. The results show that the quantities of biomass produced by the agroforestry walnut trees are higher than those produced by their forestry control trees. However, these tendency need to be qualified, because the two plots showed a great deal of variability, particularly in terms of water availability, which is one of the parameters that has been detailed in this work. Such results could provide interesting data to the farmers to promote access of agroforestry wood to conventional and/or niche markets.
Prevalence and predictors of tuberculosis among HIV patients who completed isoniazid preventive therapy (IPT) at Reach out Mbuya community health initiative
Authors: Ssekayi Wycliff , Namyalo Edity , Namayanja Josephine , Kungu Joseph 
Published: February 2023

Abstract
Background
Tuberculosis (TB) continues to be the leading cause of morbidity and mortality among human immunodeficiency virus (HIV) infected individuals in Sub Saharan Africa, including Uganda. Isoniazid prophylaxis therapy (IPT) is a major public health intervention to avert the progression of latent tuberculosis to active tuberculosis disease among people living with HIV. However, there is limited information about the influence of IPT on TB incidence and its associated risk factors among HIV positive patients in Uganda especially at Reach out-Mbuya community health initiative hence the study.
Methods
A cross sectional study was conducted among positive adult patients who completed a 6-months long daily treatment of Isoniazid preventive therapy. Sputum samples and urine samples were collected and analysed using gene xpert and lateral flow urine Lipoarabinomannan (TF LAM) tests respectively for presence of Tuberculosis. Data analysis was performed using STATA. Bivariate and multivariate logistic regression were performed to assess the risk factors associated with tuberculosis among the study population and significance estimated at 95% confidence level.
Results
A total of 103 HIV positive adults was studied. The mean age of the participants was 42.09 ± 10.49 and median age was 43. The prevalence of tuberculosis among HIV positive adult patients who completed Isoniazid preventive therapy was 5.8% (6/103). Counselling, the only factor significantly associated with TB (aOR:0.028, P-value < 0.001) had a protective effect of influencing HIV patients to complete of IPT and reduce the risk of TB infection.
Conclusion
Administration of IPT to HIV patients effectively reduces the occurrence of TB. Counselling is a significant predictor of prevention of active TB among HIV patients.
Sialyltransferase7A promotes cardiomyocyte ferroptosis induced by sorafenibthrough increase in HIF-1ɑ expression
Authors: Li Qingsong , Gong Qiuyue , Hu Maolin , Hu Xinrui , Xia Yunlong , Zhang Dongmei 
Published: February 2023

Abstract

Sorafenib is a widely used in the treatment of many different types of cancer. Studies indicate that sorafenib has been associated with several cardiotoxicities including cardiac enzyme elevations, contractile dysfunction, and heart failure. Clinical observation shows that cardiotoxicity due to sorafenib treatment is largely underestimated, but the mechanism of cardiovascular toxicity is unclear. In this study, we first reported that one of the sialyltransferase family member sialyltransferase7A (Siat7A), promotes sorafenib induced cardiomyocyte ferroptosis by stimulating hypoxia-inducible factor 1α (HIF-1ɑ) expression. Siat7A increased in cardiotoxicity of rats subjected to sorafenib infusion, myocardial hypertrophy marker ANP and α-actinin increased, while the expression of glutathione peroxidase 4 (GPX4) and SLC7A11, the markers of ferroptosis decreased. These results suggested that myocardial hypertrophy aggravated and ferroptosis increased in vivo. Siat7A overexpression significantly upregulated the level of Siat7A and cardiomyocytes ferroptosis, while Siat7A knockdown inhibited Siat7A and cardiomyocytes ferroptosis stimulated by sorafenib in vitro. HIF-1ɑ expression was stimulated by sorafenib both in vitro and in vivo. Mechanistically, we further revealed that sorafenib induced the activation of HIF-1ɑ in parallel to Siat7A in cardiomyocyte ferroptosis, that is HIF-1ɑ activation was inhibited in Siat7A knockdown cardiomyocytes and activated after Siat7Aoverexpression. Based on these findings, we conclude that Siat7A promotes cardiomyocyte ferroptosis induced by sorafenib through increase in HIF-1ɑ expression.
Prepossessing considerations for floc reduction in Cellulose Nanofibril Suspensions
Authors: Sutliff Bradley P. , Kaplan Aliya J. , Stutz Samantha , Oxley Samuel , Bortner Michael J. 
Published: February 2023

Abstract
Cellulose nanomaterials provide a promising avenue for combining composite materials with natural polymers or bio-based plastics, however, current studies on rheological characterization at high shear rates is limited. In this study, a capillary rheometer was employed to investigate the rheological characteristics of aqueous nanofibrillated cellulose suspensions (NFCs) at room temperature and shear rates above 1000 s-1. The shear rate-dependent viscosity of NFCs was characterized and monitored for viscosity-related indicators of fibril decomposition or entanglement due to the stresses induced by the high shear-rate flow. Traditional capillary rheology corrections for entrance pressure loss and irregular flow profiles were attempted to compare apparent and true rheological behaviors. Large entanglements of fibrils made the characterization of the suspensions difficult due to their ability to clog the capillary. However, appropriate preprocessing steps enabled better measurement resolution and enhanced dispersion of cellulose nanofibers, as verified by atomic force microscopy. The suspensions display shear thinning behavior and demonstrate higher entrance pressures for lower shear rates. Similar preprocessing techniques could be implemented on a large scale to enhance fibril distribution in NFC suspensions.
Additive Risk of Surgical Site Infection from More than One Risk Factor Following Craniotomy for Tumor
Authors: Maayan Omri , Lavieri Miguel E. Tusa , Babu Christopher , Chua Jason , Christos Paul J. , Schwartz Theodore H. 
Published: February 2023

Abstract
Purpose
This study seeks to expound upon risk factor etiologies for surgical site infection (SSI) and investigate their combinatorial effects on infection rate following craniotomy for neuro-oncologic pathology.
Methods
Patients who underwent neuro-oncologic craniotomy between 2006-2020 were included. Medical records were reviewed to identify the occurrence of wound infection at ≤3 months postoperatively. Potential risk factors for infection included tumor pathology, location, anesthesia type, indication, ventricular entry, foreign body, brachytherapy, lumbar drain, prior operation, prior cranial radiation, prior infection, bevacizumab, and medical comorbidities (hypertension, obesity, hyperlipidemia, other cancer, cirrhosis). Logistic regression was implemented to determine risk factors for SSI. Chi-square tests were used to assess whether the number of risk factors (e.g., 0, ≥1, ≥2, ≥3, ≥4) increases the risk of SSI compared to patients with fewer risk factors. The relative increase with each additional risk factor was also evaluated.
Results
A total of 1209 patients were included. SSI occurred in 42 patients (3.5%) by 90 days after surgery. Significant risk factors on binary logistic regression were bevacizumab (OR 40.84; p<0.001), cirrhosis (OR 14.20, p=0.03), foreign body placement (OR 4.06; P<0.0001), prior radiation (OR 2.20; p=0.03), and prior operation (OR 1.92; p=0.04). Infection rates in the combinatorial analysis were as follows: ≥1 risk factor = 5.9% (OR 2.74; p=0.001), ≥2 = 6.7% (OR 2.28; p=0.01), ≥3 = 19.0% (OR 6.5; p<0.0001), ≥4 = 100% (OR 30.2; p<0.0001).
Conclusions
Risk factors in aggregate incrementally increase the risk of postoperative SSI after craniotomy for tumor.
Fusion from a Condorcet Perspective
Authors: Tyomkin Liron , Kurland Oren 
Published: February 2023

Abstract
The fusion task is to merge document lists retrieved from a corpus in response to a query. Despite the few decades of research work on fusion, there are still no theoretical tools to formally analyze fusion methods. We use the Condorcet voting rule as a first step to this end. We then present an in-depth empirical analysis of TREC runs and existing fusion methods with respect to Condorcet. In addition, we propose two simple novel fusion approaches which are inspired by the Condorcet rule. Empirical evaluation demonstrates their merits.
Study of ground ozone and precursors along with particulate matter at residential sites in the vicinity of a power plant
Authors: Chelani Asha B. , Gautam Sneha 
Published: February 2023

Abstract
Ground ozone (O3) and its precursor variables carbon monoxide (CO), nitric oxide (NO), nitrogen dioxide (NO2), Sulphur dioxide (SO2), benzene, toluene, ethyl-benzene and xylene (BTEX) along with particulate matter of size less than 10 and 2.5 micron (PM10 and PM2.5) and meteorological variables have been studied at a residential site near the coal-fired power plant in two cities; Chandrapur and Nagpur during 2016-2019. O3 is observed to be not correlated significantly with any of its precursor variables. On a finer time scale however, a significant correlation of O3 with CO, NO, NO2 and BTEX suggested that O3 formation mechanism is driven by VOCs (mainly BTEX), CO and NOx. On the coarser scale however seasonality and other factors have distorted the correlation. Random forest model with O3 concentration as the response variable and NO2, NO, SO2, CO, BTEX, PM10 and PM2.5 as independent variables suggested that PM10, NO, CO and solar radiation are highly important variable governing the O3 dynamics in Chandrapur. In Nagpur, wind direction, relative humidity, temperature, toluene and NO2 are more important. Qualitative analysis to assess the contribution of emission sources suggested the influence of traffic emissions in Nagpur and dominance of non-traffic related emissions, mainly power plant and mining activities in Chandrapur. Hazard index is observed to be > 1 in both the cities suggesting the health hazard to the residents living in the area.
Threats of invasive alien species to Nature’s Contribution to People
Authors: Gallardo Belinda , Bacher Sven , BARBOSA A. Marcia , Gallien Laure , Gonzalez-Moreno Pablo , Martínez-Bolea Víctor , Sorte Cascade , Vimercati Giovanni , Vilà Montserrat 
Published: February 2023

Abstract
Invasive Alien Species are a major driver of biodiversity loss, but their threats to nature’s contributions to people (NCP) at large spatial scales remain largely undetermined. Here we quantify and map the current and potential threat posed by invasive species of concern in Europe to regulating, material and nonmaterial NCP. We show that the current threat of biological invasions is concentrated in human-altered areas unable to support major regulating and cultural NCP, such as habitat maintenance, hazards regulation, and human physical and psychological experiences. Furthermore, the top NCP contributing areas of Europe have little accessibility and climatic suitability for the future spread of invaders. However, the threat posed by invasive species is high in areas providing economically strategic NCP, such as the regulation of freshwater quality and the provision of food, where the expansion of invaders may cause the greatest impacts. This threat is likely to intensify with climate change. Hotspots combining high favourability for invasion and high NCP supply represent between 0 and 13% of the European area, depending on the invasive species and contribution considered, and should become priorities for research and conservation. Our findings can be used to guide the prioritisation of management actions to prevent, minimise and mitigate the adverse effects of IAS on biodiversity and related ecosystem services.
Efficacy testing of non-oxidizing biocides for polyamide membrane biofouling prevention using a modified CDC biofilm reactor
Authors: Da-Silva-Correa Luiz H. , Aasen Kirsten , Gamm Nicole E. , Godoy Rafaela , Rahmati Negar , Buckley Heather Louisa 
Published: February 2023

AbstractBiofouling is one of the most challenging obstacles faced by reverse osmosis (RO) membrane systems to supply potable water. Currently, biofouling is imperfectly handled by RO feed water pre-chlorination, which is associated with the production of carcinogenic disinfection by-products. To propose a safer alternative to control biofouling in RO drinking water applications, this study investigates the efficacy of five biocides to prevent and remove Pseudomonas aeruginosa biofilms from RO membranes: 2-methyl-4-isothiazolin-3-one (MIT); 2,2-dibromo-3-nitrilopropionamide (DBNPA); sodium bisulfite (SBS); sodium benzoate (SB); and ethyl lauroyl arginate (LAE). Experiments were conducted on the Center for Disease Control (CDC) Biofilm Reactor (CBR) with biocidal dosing estimated on 96-well microtiter plates. Confocal Scanning Laser Microscopy (CLSM) and Scanning Electron Microscopy (SEM) were used to analyze the biocides' anti-biofilm efficacies under dynamic conditions relative to minimum biofilm inhibitory and eradication concentrations. The results in this study indicated that LAE presented the best anti-biofilm efficacies in treating P. aeruginosa biofilms when compared to all studied biocides; it not only prevented biofilm formation (&gt;98%) but also it effectively removed pre-established biofilms (&gt;99%) from RO membrane coupons. Therefore, due to safety and efficacy, LAE is an excellent candidate for controlling biofouling in drinking water RO membrane systems.
The influence of main channel velocity and water depth changes on the hydrodynamic characteristics of lateral water intake in a tidal channel
Authors: Wang Shan , Bi Qilong , He Wei , Zhang Jian 
Published: February 2023

Abstract
A tidal channel will be affected by the intrusion of seawater, so the current and water depth in the channel will change at every moment. These changes are critical to the hydrodynamic characteristics of water intakes in tidal rivers. This paper establishes a 3D model and validates it through laboratory models, then analyzes the influences of dynamic change of flow velocity and water depth, and the amplitude changes of velocity and water depth on the secondary flow in the water withdrawal process. With the increase of the main flow velocity and the decrease of the water depth, diversion width at the water intake decreases, the peak velocity increases, and the intensity of the secondary flow also increases. With the increase of the velocity of the main channel and the changing rate in water depth, the lag time of the velocity change at the water intake is also longer, and the peak velocity will be greater than the velocity of the constant flow. The influence of the water depth change is greater than that of the main channel velocity change. Combining these four factors, more sand may be washed into the inlet channel under conditions of high flow and low water depth.
Oteseconazole: First Approved Orally Bioavailable and Selective
CYP51 Inhibitor for the Treatment of Patients with Recurrent
Vulvovaginal Candidiasis
Authors: De Surya K. 
Published: February 2023

Abstract:
Oteseconazole was approved by the US FDA in April 2022. It is the first approved
selective and orally bioavailable CYP51 inhibitor for the treatment of patients with
recurrent Vulvovaginal candidiasis. Herein, we describe its dosage, administration, chemical
structure, physical properties, synthesis, mechanism of action, and pharmacokinetics.
Natural Products-based Drugs: Potential Drug Targets Against Neurological
Degeneration
Authors: Mittal Pooja , Goyal Rajat , Kapoor Ramit , Wan Chunpeng , Gautam Rupesh K. 
Published: February 2023

Abstract:
Phytochemicals or natural products have been studied extensively for their potential in the
treatment of neurodegenerative diseases (NDs) like Parkinson’s disease, Alzheimer’s disease, etc. The
neuronal structure loss and progressive dysfunction are the main characteristics of these diseases. In
spite of impressive and thorough knowledge of neurodegenerative molecular pathways, little advancement
has been found in the treatment of the same. Moreover, it was proved that natural products
can be used efficiently in the treatment of NDs while certain issues regarding the patient's safety and
clinical data are still existing. As ND is a bunch of diseases and it will start the myriad of pathological
processes, active targeting of the molecular pathway behind ND will be the most efficient strategy to
treat all ND-related diseases. The targeting pathway must prevent cell death and should restore the
damaged neurons. In the treatment of ND and related diseases, natural products are playing the role of
neuroprotective agents. This review will target the therapeutic potential of various phytochemicals
which shows neuroprotective action.
Breast I-131 Uptake in a Postpartum Woman with Thyroid Cancer: A
Case Report
Authors: Qiao Jie , Zeng Ni 
Published: February 2023

Background:
I-131 uptake in the breast could be occasionally observed in differentiated
thyroid cancer who received I-131 scintigraphy or therapy. Herein, we report a postpartum patient with
papillary thyroid cancer with breast uptake who received I-131 therapy.

Case report:
A 33-year-old postpartum woman with thyroid cancer received 120mCi(4440MBq) I-
131 therapy 5 weeks after she ceased to breastfeed. The second day after ingestion of I-131, wholebody
scintigraphy demonstrated asymmetric and marked uptake in bilateral breasts. The radiation dose
of I-131 in the lactating breast would decrease rapidly by reducing the activity of breasts and expressing
breast milk with an electric pump once daily.

Results:
The sixth day after administration, scintigraphy demonstrated weak uptake in bilateral breasts.

Conclusion:
Physiologic I-131 uptake in the breast could occur in a postpartum woman with thyroid
cancer who received I-131 therapy. In this patient, we find that the radiation dose of I-131 accumulated
in the lactating breast would decrease rapidly through reducing the activity of breasts and expressing
breast milk with an electric pump, which may be a better choice for the postpartum patient who was
not given lactation-inhibiting medications and had I-131 therapy.
Novel 2,4- diaminopyrimidine 5-carboxamides as c-Jun N-terminal Kinase
Inhibitors for Treating the Liver Fibrotic Disorder
Authors: De Surya K. 
Published: February 2023

Abstract:
Diaminopyrimidine compounds having the following general structure (I), compositions
comprising an effective amount of a diaminopyrimidine compound, and methods
for treating or preventing fibrotic liver disorders or other diseases associated with the JNK
pathway are discussed in this patent study.