bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between serum hepatitis B core-related antigen and hepatitis B virus DNA in treatment-naïve patients with hepatitis B cirrhosis: A cross-sectional study
Authors: Xu Baiguo , Jia Lian , Cui Hao , Liu Ying , Guo Hua , Liu Anjing , Ding Xian , Yin Weili , Xiang Hui-ling 
Published: May 2023

Abstract
Aims. The relationship between hepatitis B core-related antigen (HBcrAg) and hepatitis B virus (HBV) DNA has already been adequately researched in patients with chronic hepatitis B (CHB) infection, but there are only a few researches yet on the correlations between HBcrAg and HBV DNA in treatment-naïve patients with hepatitis B cirrhosis. Here we explore the correlation between HBcrAg and HBV DNA in this population. Methods. Available data and samples of 98 untreated patients with hepatitis B cirrhosis between October 2018 and October 2019 were analysed. Statistical analyses included baseline characteristics, univariate analysis, stratification analysis, three different analytical models, and a generalized additive model. Results. After adjusting for all recorded confounders (sex, age, diagnosis of primary hepatic carcinoma, total bilirubin（TBIL）, hepatitis B surface antigen (HBsAg), hepatitis B e antigen(HBeAg), Child–Pugh class, family history of HBV infection, family history of hepatocellular carcinoma(HCC), alcohol-related liver disease (ALD), and diabetes mellitus), a linear relationship was detected between HBcrAg and HBV DNA (β=0.59, 95%CI=0.34–0.84, P<0.0001). The variational trend of HBcrAg and HBV DNA in each stratified variable (sex, age, HBeAg, family history of HBV infection, family history of HCC, diabetes mellitus, diagnosis of primary hepatic carcinoma, Child–Pugh class, and ALD) were consistent. Conclusion. There was a linear and positive correlation between HBcrAg and HBV DNA in treatment-naïve patients with hepatitis B cirrhosis.
Undercoordinating OH- network via dispersed electrostatic fields for ultralow overpotential of oxygen evolution in alkaline electrolyte
Authors: Li Yang , Wang Shuijing , Huang Hengming , Kou Jiahui , Lu Chunhua , Xu Zhongzi , Ye Jinhua 
Published: May 2023

AbstractFor the oxygen evolution reaction (OER), proton transfer (PT) and diffusive transfer (DT) are two main transfer modes of the key reactant OH−in alkaline electrolyte. Thereinto, the faster PT mode is more favored for OER performance, which requires the 3 coordination number (undercoordination) between water molecule and the oxygen of OH−. However, the 4-coordinated OH−(hypercoordination) is usually the more stable state and the strong H2O-OH−bond is hard to break, making it a big challenge to obtain the undercoordinated OH−network for successive PT. Here we utilize the dispersed electrostatic fields providing the strong electrostatic attraction to polarized water as well as the repulsion to OH−to break the H2O-OH−bond, and therefore the undercoordinated OH−network can be formed to provide the accelerated OER kinetics. More interestingly, the electrolyte activity is still almost the same after 30 days, and even after removing the dispersed electrostatic fields, the return of the water coordination and the corresponding activity is rather slow (~ 12 h). The universality of the strategy is demonstrated in terms of the OER enhancement of various catalysts including Ni(OH)2, Co3O4,Ni3S2, NiSx/C3N4and pure Ni foam, which brings the lowest overpotential reported so far (20 mV at 10 mA cm− 2).
Beyond the Dams - Combatting Hydropower Over-reliance &amp; Securing Pathways for a Low-carbon Future for Laos' Electricity Sector using OSeMOSYS (Open-Source Energy Modelling System)
Authors: Wong Sebastian , Rogelj Joeri , Yeganyan Rudolf , Tan Naomi , Cannone Carla , Howells Mark 
Published: May 2023

Abstract
Since the onset of the millennium, Laos has seen exponential growth in the past decades, becoming one of the fastest growing economies of the 21st century. Much of its success owes to its emerging position as ‘the battery of Southeast Asia’ through the exportation of mostly hydropower. While this has brought about almost-universal praise as the beacon of ‘sustainable development’, the detractors of this notion are not without merit. A growing amount of evidence demonstrates that if Laos continues hydropower expansion in its current trajectory, a multitude of implications can stand to disenfranchise the most marginalised in Laos and beyond. Alongside this predicament, much of the world is seeking to set a net-zero CO2 emissions by 2050 in order to avoid the most extreme consequences of the climate crisis.
This report seeks to draw up potential pathways to both pressing issues through utilising OSeMOSYS (Open-Source Energy Modelling System), a long-term energy system modelling tool, to create seven scenarios that would provide insight into what pathways there are for the Lao electricity sector to wean its hydropower dependency and still be low-carbon in different capacities.
The modelling output suggests that a low-carbon future not overly-reliant on hydropower is highly feasible and five policy recommendations have transpired through drawing on common themes and key insights of the modelling output. They include the prioritisation and promotion of non-hydro RE, most namely biomass as it serves to replace coal within Laos’ generation mix, the encouragement of small-scale electricity production, transmission and distribution grid improvements and the establishment of an independent power sector regulator. Further research is encouraged to reflect the dynamic changes within RE technology development and improved upon datasets in order for increased accuracy, as well as analysis on a whole energy system level.
Collaborative Dishonesty with Unequal Profits - an Experimental Investigation
Authors: braut beatrice , Valle Nives Della , Piovesan Marco 
Published: May 2023

Abstract
We investigate how facing asymmetric incentives influences collaboration in a setting where subjects can cheat. In the experiment, subjects have to cooperate to receive payment, which depends on their reports about a random outcome, having the opportunity to be dishonest. We compare a situation where cooperation leads to gains that are equally divided between the two individuals to one where the division is unequal. We analyze the evolution of collaborative behavior over time and look at individual strategies. We find that corruptive collaboration is not diluted when personal interests are repeatedly in conflict. Dishonesty is multifaceted and less evident, therefore potentially more damaging. Subjects learn with experience how to dishonestly collaborate, also using their reports as signals. They coordinate on compromise distributions even if these give smaller payments, suggesting that lying gets indeed less costly in presence of asymmetric payments.
JEL classifications: C92, D01
Assessing the Relationship between Migraine and Sino-Nasal Symptoms and Diseases Among Syrian Private University Students: A Case-Control Study
Authors: Kadri Louloua Al , Nahas Louei 
Published: May 2023

Abstract
Background: Migraine is a common chronic and disabling condition, diagnosed late in most patients. Furthermore, Sino- nasal diseases are severe stressing conditions that can correlate with headaches and migraine. This study aimed to assess the relationship between migraine and Sino- nasal diseases among Syrian private university students.
Methods: A case-control study was conducted among students of the Syrian Private University in Damascus, and written informed consent was obtained from all participants. A self-administered and completed Arabic questionnaire on migraine and its relationship to Sino- Nasal diseases was used in previous studies. The study included 963 students, of whom 417 were students who had migraines, and 546 were controls who did not have migraines. The Chi-square test was used to assess the relationship between cases and controls and study variables. P value was considered at < 0.05.
Results: Out of 963 students, 30.7% were male, and 69.3% were female. With an average age of 23.8. Most of the students were from the Faculty of Human Medicine, 27.1%, and were in their final years of study 24%. Most Sino- nasal diseases were related to migraine including nasal obstruction, the need to blow to empty, ear pain, pressure, or pain in facial bones. Sino- nasal Score was significantly related to migraine. The severity of Sino- nasal symptoms were significantly associated with migraine.
Conclusions: The results of this study indicate that the diseases and symptoms of the nose and sinuses are significantly associated with migraine. Healthcare providers must raise awareness about this relationship to evaluate it and provide appropriate advice and treatment at an early onset.
Chronic ingestion of soy peptide supplementation reduces aggressive behavior and abnormal fear memory caused by juvenile social isolation
Authors: Tamura Hideki , Miyazaki Akiko , Kawamura Takashi , Gotoh Hikaru , Yamamoto Naoki , Narita Minoru 
Published: May 2023

AbstractJuvenile loneliness is a risk factor for psychopathology in later life. Deprivation of early social experience due to peer rejection has a detrimental impact on emotional and cognitive brain function in adulthood. Accumulating evidence indicates that soy peptides have many positive effects on higher brain function in rodents and humans. However, the effects of soy peptide use on juvenile social isolation are unknown. Here, we demonstrated that soy peptides prevented the deterioration of behavioral and cellular functions resulting from juvenile socially-isolated rearing. We found that prolonged social isolation post-weaning in male C57BL/6J mice resulted in higher aggression and impulsivity and fear memory deficits at 7 weeks of age, and that these behavioral abnormalities, except impulsivity, were mitigated by ingestion of soy peptides. Furthermore, we found that daily intake of soy peptides caused upregulation of postsynaptic density 95 in the medial prefrontal cortex, phosphorylation of the cyclic adenosine monophosphate response element binding protein in the hippocampus of socially isolated mice, and altered the microbiota composition. These results suggest that soy peptides have protective effects against juvenile social isolation-induced behavioral deficits via synaptic maturation and cellular functionalization.
Impact of social networks on fertilizer use efficiency in China: How does green fertilization technology work?
Authors: Chang Fangyuan , Liu Li , Wang Yu , Liu Jundi , Bai Xiuguang 
Published: May 2023

Abstract
Improving fertilizer use efficiency (FUE) is an effective way to reduce the fertilizer use and non-point source pollution in agriculture production in China. Existing research related to fertilizer use efficiency ignores the impact of famers’ social networks, which can significantly affect the fertilizer use and its efficiency. This study examined how farmers' social networks and adoption of green fertilization technology mediate the impact FUE in kiwifruit production in Shaanxi province, China. The results show that the kiwifruit production had a low FUE, with an average value of 0.333. Social networks positively influenced FUE, with network trust and learning having the greatest impact. Adoption of green fertilization technology mediated the social network's influence on FUE, mainly promoted by network trust and learning. Farmers’ experience in agricultural production, joining cooperative society, the quantity of village agricultural supply points had a significant positive impact on FUE, while age and gentle of the head of household had a significant negative impact of FUE. Planting scale had a U-shape impact on FUE. Policies aimed at improving FUE and reducing non-point source pollution should, therefore, focus on strengthening social networks and encouraging green fertilization technology adoption, are essential for reducing non-point source pollution and promoting sustainable agricultural production.
Energy Efficient Resource Allocation for Re-configurable
Intelligent Surface-Assisted Wireless Networks
Authors: Bidabadi Samaneh , Ouameur Messaoud Ahmed , Bagaa Miloud , Massicotte Daniel 
Published: May 2023

Abstract
This paper considers energy-efficient resource allocation in reconfigurable intelligent surface (RIS)-assisted multiple-input-single-output (MISO) communication systems. In particular, it revisits the energy efficiency (EE) problem that uses the alternating optimization (AO) approach. In each AO's iteration, RIS phase optimization is achieved using gradient decent method whose convergence is unfortunately not guaranteed. We therefore, discuss the convergence issue herein while proposing two alternatives, namely, the Wolfe based gradient-descent algorithm (GAW) and the trust region (TR) method. However, the optimal transmit power allocation is obtained using Dinkelbach’s algorithm. Our results show that the proposed methods outperform the existing method that uses sequential fractional programming (SFP) for phase optimization and the traditional relay-based method.
The copper-assisted dissolution of magnetite in hydrazine-based inorganic solution
Authors: Banerjee Ayantika , Choi Wangkyu , Choi Byung-Seon , Kim Seon-Byeong 
Published: May 2023

Abstract
A protective oxide layer forms on the material surfaces of a Nuclear Power Plant during operation due to high temperature. These deposited oxides are iron oxides such as Fe3O4, Fe2O3, and mixed ferrites such as nickel ferrites, chromium ferrites, and cobalt ferrites. Developing a new chemical decontamination technology for domestic CANDU-type reactors is challenging due to variations in oxide compositions from different structural materials in a Pressurized Water Reactor (PWR) system. The Korea Atomic Energy Research Institute (KAERI) has already developed a chemical decontamination process for PWRs called 'HyBRID' (Hydrazine-Based Reductive metal Ion Decontamination) that does not use organic acids or organic chelating agents at all. To improvise this chemical decontamination technology for the Pressurized Heavy Water Reactor (PHWR) system, we investigated the role of Cu in magnetite dissolution. The redox cycle of copper in the presence of hydrazine and magnetite in the solution does provide a good dissolution behavior of magnetite.
Transcriptome and histological analyses on the uterus of freckle egg laying hens
Authors: Duan Guochao , Liu Wei , Han Haixia , Li Dapeng , Lei Qiuxia , Zhou Yan , Liu Jie , Wang Jie , Du Yuanjun , Cao Dingguo , Chen Fu , Li Fuwei 
Published: May 2023

Abstract
Background: In this study, we investigated why freckle eggs are formed. Given that eggshells form in the uterus, we hypothesized that uterus structure and function directly affect freckle egg production. To verify this hypothesis, we collected uterine tissue from laying hens (418 days old) that laid normal eggs (group C, n = 13) and freckle eggs for 7 consecutive days (group T, n = 16).
Results: We then performed histopathology and transcriptome analyses on the collected tissue. When compared with group C, uterine junctional epithelial cells in group T showed significant defects and cilia loss, and epithelial tissue was poorly intact. From transcriptomics, genes that met (|log2FC|) ≥ 1 and P < 0.05 criteria were screened as differentially expressed genes (DEGs). We identified a total of 136 DEGs, with 101 up- and 35down-regulated genes from our RNA-seq data. DEGs identified by enrichment analyses, which were potentially associated with freckled egg production were: IFI6, CCL19, AvBD10, AvBD11, S100A12, POMC, and UCN3. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses showed that pathways were associated with immunoreaction and stress stimulation, e.g., complement activation, interleukin-1 cell reactions, viral responses, cell reactions stimulated by corticotropin releasing hormone, steroid hormone mediated signaling pathways, staphylococcal infections, B cell receptor signaling pathways, and natural killer cell mediated cytotoxicity.
Conclusions: From these data, we reasoned that freckle eggs may result from abnormal immune responses and impaired uterine functions induced by stress. Therefore, the uterus of laying hens in a state of stress and abnormal immune function can cause the appearance of freckled eggs.
Invasive and native plants show different root responses to feedback-mediated soil heterogeneity
Authors: Chen Duo , Kleunen Mark van , Wang Yong-Jian , Yu Fei-Hai 
Published: May 2023

AbstractBackground and AimsSoil heterogeneity can be caused by plant-soil feedback (PSF), but little is known about how such PSF-mediated soil heterogeneity affects plant growth and the distribution of roots. Moreover, as invasive and native plant species frequently differ in PSF and in root-foraging ability, they may also differ in their responses to PSF-mediated soil heterogeneity.MethodsWe first conditioned soils by 16 plant species (eight pairs of invasive alien and native species). Then, we grew each species in a homogeneous treatment with unconditioned soil and in three heterogeneous treatments with patches filled with two of the following three soils: unconditioned soil (control soil), soil conditioned by the target species (home soil) or soil conditioned by the other species in a pair (foreign soil).ResultsInvasive species were more negatively affected by the heterogeneous treatment with control-soil and home-soil patches than natives. In the heterogeneous treatment with home-soil and foreign-soil patches, root mass of the invasive species was much greater in the foreign-soil than in the home-soil patches, whereas the reverse was true for natives.ConclusionAlthough invasive species suffered more from conspecific PSF, root foraging allowed them to avoid home soil. In the long term, this could potentially help invasive species gain a competitive advantage over natives.
Refined Protocol for Newly Onset Identification in Non-obese Diabetic Mice: An Animal-friendly, Cost-Effective, and Efficient Alternative
Authors: Sung Hsiang-Hsuan , Liao Chia-Chi , Hsieh Chia-Chun , Chou Min-Yuan , Huang Chuan-Chuan , Lin Jhih-Hong , Lee Shu-Hsien 
Published: May 2023

Abstract
Determining the onset of diabetes based on blood glucose (BG) levels can be challenging in mouse models, as thresholds can vary from 200 to 400 mg/dl in one or two consecutive tests. Urine glucose (UG) levels can be detected non-invasively as another criterion of diabetic condition, but it is considered a lagging indicator due to physiological downstream from BG. In this study, we demonstrate that the lagging period is practically unnoticeable in spontaneously model of non-obese diabetic (NOD) mice which develop autoimmune diabetes randomly from 12 to 32 weeks of age. After comprehensive measurements across entire onset window in 60 female NOD mice, we concluded that BG measurements before UG reaches 250 mg/l contribute nearly nothing to diabetic identification. Refined protocol encompasses UG survey twice-weekly to select positive candidates for further intensive BG measurements is recommended and tested in another batch of 60 mice. This protocol precisely identified every newly onset individual with average BG of 350 mg/dl which is lower than conventional once-weekly BG survey alone around 400 mg/dl. Moreover, intensive measurements near onset indicate two BG+ within four days can serve as a refined onset criterion, allowing for dynamic arrangement of sampling time to make the process even more efficient in practice. From 3R perspectives, this protocol potentially saves dozens of bleeding procedures in one individual mouse and hundreds of lancets, BG strips, labors, and unnecessary animal suffering during batch screening that serve as a convenient alternative for newly onset identification of diabetes.
The Improvement of Fertility by Switching to Normal Diet and Restoring BTB Integrity in HFD-Induced Obese Male Mice
Authors: Zhang Wenjing , Tian Zhenhua , Qi Xiangyu , Chen Pengcheng , Yang Qian , Guan Qingbo , Ye Jifeng , Yu Chunxiao 
Published: May 2023

Abstract
Obesity is a prominent risk factor for male infertility, and a high-fat diet is an important cause of obesity. Therefore, diet control can reduce body weight and regulate blood glucose and lipids, but it remains unclear whether it can improve male fertility and its mechanism. This study explores the effects of switching from a high-fat diet (HFD) to a normal diet (ND) on the fertility of obese male mice and its related mechanisms. The mice in the high-fat diet group indicated elevated lipids and blood glucose, decreased serum FSH, and disrupted testicular BTB integrity, reducing fertility. After the fat intake was controlled by switching to a normal diet, body weight and epididymal fat weight were significantly reduced, and the deposition of interstitial lipids in the testicles also decreased. Following further analysis, the testicular oxidative stress levels were reduced to normal, and BTB integrity was restored, ultimately leading to increased fertility. Our study confirms diet control by switching from a high-fat diet to a normal diet can effectively reduce body weight, improve BTB integrity in male mice, and enhance fertility, providing an effective treatment option for obese male infertility.
Long Non-coding RNA NRSN2-AS1 promotes ovarian cancer progression through targeting PTK2/β-catenin pathway
Authors: Shen Cong , Wu Yi-Bo , Li Shen-Yi , Liu Jin-Yan , Xue Jia-Jia , Xu Jin-Fu , Chen Ting , Cao Tian-Yue , Zhou Hui , Wu Tian-Tian , Dong Chun-Lin , Qiao Long-Wei , Hou Shun-Yu 
Published: May 2023

Abstract
As a common malignant tumor among women, ovarian cancer poses a serious threat to their health. This study demonstrates that long non-coding RNA NRSN2-AS1 is over-expressed in ovarian cancer tissues using patient sample and tissue microarrays. In addition, NRSN2-AS1 is shown to promote ovarian cancer cell proliferation and metastasis both in vitro and in vivo. Mechanistically, NRSN2-AS1 stabilizes protein tyrosine kinase 2 (PTK2) to activate the β-catenin pathway via repressing MG-53-mediated ubiquitinated degradation of PTK2, thereby facilitating ovarian cancer progression. Rescue experiments verify the function of the NRSN2-AS1/PTK2/β-catenin axis and the effects of MG53 on this axis in ovarian cancer cells. In conclusion, this study demonstrates the key role of the NRSN2-AS1/PTK2/β-catenin axis for the first time and explores its potential clinical applications in ovarian cancer.