bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of therapeutic exercise and cognitive‐behavioural therapy combined protocol on functionality, pain and joint health in people with haemophilia: Secondary analysis of a controlled trial
Authors: Moreno‐Segura Noemí , Pérez‐Alenda Sofía , García‐Dasí María , Carrasco Juan J. , Marqués‐Sulé Elena , Querol Felipe , Bonand Santiago , Aguilar‐Rodríguez Marta 
Published: December 2022

AbstractBackgroundHaemophilic arthropathy is one of the main causes of morbidity in people with haemophilia (PWH), inducing pain and reduced functionality. Therefore, PWH are complex patients and must be approached from a multidisciplinary perspective.ObjectivesTo evaluate the effectiveness of a therapeutic exercise and cognitive‐behavioural therapy (CBT) combined protocol on functionality, pain, and joint health of PWH, arthropathy and chronic pain. Treatment satisfaction was also evaluated.MethodsA single‐blinded clinical trial with 21 PWH in prophylactic regimen was carried out. Participants were divided into an experimental group (EG, n = 11) and a control group (CG, n = 10). The EG underwent a 4‐month programme of home‐based therapeutic exercise plus CBT, whilst CG performed their daily activities. Patients were evaluated at baseline, post‐intervention and after 12 additional weeks. Measures of functionality (Haemophilia Activities List, Timed Up and Go Test, 2‐Minutes‐Walking‐Test and Sit‐to‐Stand Test), pain (PainDETECT and Visual Analogue Scale) and joint health (Haemophilia Joint Health Score) were taken. Related dimensions of the A36 Haemophilia Quality of Life Questionnaire were calculated. Effects were calculated using a two‐factor ANOVA.ResultsThe EG showed significant improvements in function (p < .001), pain (p < .001), joint damage (p = .006), and satisfaction with the treatment (p = .006) dimensions of the A36 Haemophilia Quality of Life Questionnaire, as well as in pain measured with the Visual Analogue Scale (p = .008) and PainDETECT (p = .035).ConclusionsThe combined physiotherapy and CBT protocol showed a partial improvement in functionality, pain and joint health of PWH, arthropathy and chronic pain. In addition, participants were satisfied with the treatment.
Putting humans back in the loop: An affordance conceptualization of the 4th industrial revolution
Authors: Melville Nigel P. , Robert Lionel , Xiao Xiao 
Published: December 2022

AbstractThe current technology epoch—sometimes called the fourth industrial revolution (4IR)—involves the innovative application of rapidly advancing digital technologies such as artificial intelligence. Societal implications of the 4IR are significant and wide‐ranging, from life‐saving drug development to privacy loss and app addiction. A review of the information systems literature, however, reveals a narrow focus on technology‐enabled business benefits. Scant research attention has been paid to the role of humans and humanistic outcomes. To spur new research addressing these issues, formalised affordance theory is employed to develop a new 4IR conceptualization. Four groupings of affordances that capture salient 4IR action possibilities are developed within two categories: machine emulation of human cognition (expansive decision‐making and creativity automation) and machine emulation of human communication (relationship with humans and intermachine teaming). Implications are explored in the context of human‐machine coworking and the development of artificial intelligence safety regulations. Overall, the affordance conceptualization of the 4IR advances a new sociotechnical lexicon of action possibilities and their joint enactment in achieving humanistic and instrumental outcomes, enabling alignment of the scope of 4IR research with the scope of 4IR phenomena—and bringing humans back into the loop.
Fabrication of baicalein‐encapsulated zeolitic imidazole framework as a novel nanocomposited wound closure material to persuade pH‐responsive healing efficacy in post‐caesarean section wound care
Authors: Yang Jing , Chen Aner , He Xiaobo , Lu Shuangji 
Published: December 2022

AbstractBaicalein is a plant‐derived compound, it has widespread attention among biomedical researchers due to its biocompatibility and efficient biological activities. But it has non‐solubility in physiological conditions and short bioavailability in the clinical process. The Discovery of a stimuli‐based drug delivery system (DDS) is a perfect strategy to improve the bioactivity of baicalin in post‐caesarean section wound care. We prepared a baicalein‐encapsulated pH‐responsive DDS with a zeolite imidazole framework‐8 (ZIF‐8) as a carrier. We investigated the material characteristics of DDS in terms of crystal structure, surface area morphology, particle size, FTIR, UV–vis, Powder XRD, and BET analysis techniques. The in vitro cytotoxicity, biocompatibility, and cell proliferation properties of BA@ZIF‐8 were assessed against human fibroblast L929 cells. In vitro studies showed that BA@ZIF‐8 nanocomposite significantly enhanced the biocompatibility against L929 cells after 72 h post‐exposure. The pH‐responsive drug release kinetics shows excellent baicalein release under acidic conditions and without unwanted drug release in physiological conditions. Wound scratch assay results revealed, that BA@ZIF‐8 nanocomposite‐treated cells exhibit the fastest cell proliferation and migration process in a very short period. In the antibacterial activity study, nanocomposite exposed dose depended on inhibition against wound infectious pathogens. The overall study signifies that BA@ZIF‐8 nano‐DDSs are effective and suitable DDS for stimuli‐based post‐caesarean section wound care.
In vivo observations of biofilm adhering to a dialkylcarbamoyl chloride‐coated mesh dressing when applied to diabetes‐related foot ulcers: A proof of concept study
Authors: Malone Matthew , Radzieta Michael , Schwarzer Saskia , Walker Amy , Bradley Justin , Jensen Slade O. 
Published: December 2022

AbstractIn this proof‐of‐concept study of twenty participants, we sought to determine if a DACC (Dialkylcarbamoyl chloride)‐coated mesh dressing demonstrates an ability to adhere biofilm when placed on Diabetes Related Foot Ulcers (DRFUs) with chronic infection. The study also sought to determine if removal of the DACC‐coated mesh dressings contributes to reducing the total number of bacteria in DRFUs, by exploring the total microbial loads, microbial community composition, and diversity. Standard of care was provided in addition to the application of DACC or DACC hydrogel every three days for a total of two weeks. Wound swabs, tissue curettage, and soiled dressings were collected pre and post‐treatment. Tissue specimens obtained pre‐treatment were analysed with scanning electron microscopy (SEM) and peptide nucleic acid fluorescent in situ hybridisation (PNA‐FISH) with confocal laser scanning microscopy and confirmed the presence of biofilm in all DRFUs. SEM confirmed the presence of biofilms readily adhered to soiled DACC‐coated mesh dressings pre‐ and post‐treatment in all participants. Real‐time quantitative polymerase chain reaction (qPCR) demonstrated the mean total microbial load of DRFUs in 20 participants did not change after two weeks of therapy (pre‐treatment = 4.31 Log10 16 S copies (±0.8) versus end of treatment = 4.32 Log10 16 S copies (±0.9), P = .96, 95% CI −0.56 to 0.5). 16 S sequencing has shown the microbial composition of DACC dressings and wound swabs pre‐ and post‐treatment remained similar (DACC; R = −.047, P = .98, Swab; R = −.04, P = .86), indicating the microbial communities originate from the ulcer. Biofilms adhere to DACC‐coated mesh dressings; however, this may not reduce the total microbial load present within DRFU tissue. Wound dressings for use in hard‐to‐heal wounds should be used as an adjunct to a good standard of care which includes debridement and wound bed preparation.
Elevated fibrosis burden as assessed by MRI predicts cryoballoon ablation failure
Authors: Boyle Patrick M. , Sarairah Sakher , Kwan Kirsten T. , Scott Griffin D. , Mohamedali Farzana , Anderson Carter A. , Bifulco Savannah F. , Ordovas Karen G. , Prutkin Jordan , Robinson Melissa , Sridhar Arun R. , Akoum Nazem 
Published: December 2022

AbstractIntroductionLate‐gadolinium enhancement magnetic resonance (LGE‐MRI) imaging is increasingly used in management of atrial fibrillation (AFib) patients. Here, we assess the usefulness of LGE‐MRI‐based fibrosis quantification to predict arrhythmia recurrence in patients undergoing cryoballoon ablation. Our secondary goal was to compare two widely used fibrosis quantification methods.MethodsIn 102 AF patients undergoing LGE‐MRI and cryoballoon ablation (mean age 62 years; 64% male; 59% paroxysmal AFib), atrial fibrosis was quantified using the pixel intensity histogram (PIH) and image intensity ratio (IIR) methods. PIH segmentations were completed by a third‐party provider as part of the standard of care at our hospital; Image intensity ratio (IIR) segmentations of the same scans were carried out in our lab using a commercially available software package. Fibrosis burdens and spatial distributions for the two methods were compared. Patients were followed prospectively for recurrent arrhythmia following ablation.ResultsAverage PIH fibrosis was 15.6 ± 5.8% of the left atrial (LA) volume. Depending on threshold (IIRthr), the average IIR fibrosis (% of LA wall surface area) ranged from 5.0 ± 7.2% (IIRthr = 1.2) to 37.4 ± 10.9% (IIRthr = 0.97). An IIRthr of 1.03 demonstrated the greatest agreement between the methods, but spatial overlap of fibrotic areas delineated by the two methods was modest (Sorenson Dice coefficient: 0.49). Fourty‐two patients (41.2%) had recurrent arrhythmia. PIH fibrosis successfully predicted recurrence (HR 1.07; p = .02) over a follow‐up period of 362 ± 149 days; regardless of IIRthr, IIR fibrosis did not predict recurrence.ConclusionsPIH‐based volumetric assessment of atrial fibrosis was modestly predictive of arrhythmia recurrence following cryoballoon ablation in this cohort. IIR‐based fibrosis was not predictive of recurrence for any of the IIRthr values tested, and the overlap in designated areas of fibrosis between the PIH and IIR methods was modest.Caution must therefore be exercised when interpreting LA fibrosis from LGE‐MRI, since the values and spatial pattern are methodology‐dependent.
Characterizing caregiving supportive services use by caregiving relationship status
Authors: Travers Jasmine L. , Rosa William E. , Shenoy Shivani , Bergh Marissa , Fabius Chanee D. 
Published: December 2022

AbstractBackgroundInformal caregivers of older adults experience a high degree of psychosocial burden and strain. These emotional experiences often stem from stressful tasks associated with caregiving. Caregiving supportive services that provide assistance for stressful tasks are instrumental in alleviating caregiving burden and strain. Research is limited on what types of supportive services caregivers are utilizing by relationship status and their source of information regarding these services. We sought to characterize caregiving supportive services use by caregiver relationship status.MethodsWe analyzed cross‐sectional data from the 2015 National Study of Caregiving limited to caregivers of older adults ≥65 years of age. Caregiver relationship status (i.e., spouse, child, other relative/non‐relative) was the independent variable. Type of supportive service and source of information about supportive services were the dependent variables. Bivariate analyses were performed to examine the association with caregiver relationship status and associations between use of caregiving supportive services and caregiver and care recipient characteristics. Among service users, we measured associations between caregiver relationship status, type of supportive services used, and source of information about supportive services.ResultsOur sample consisted of 1871 informal caregivers, 30.7% reported using supportive services. By caregiver relationship status, children had the greatest use of supportive services compared to spouses and other relatives/non‐relatives (46.5% vs. 27.6% vs. 25.9%, p = <0.01, respectively). Among users of services, there were no differences in type of services used. Spouses primarily received their information about services from a medical provider or social worker (73.8%, p = <0.001).ConclusionOur findings highlight the need to ensure that other caregiving groups, such as spouses and other relatives/non‐relatives, have access to important supportive services such as financial support. Medical providers and/or social workers should be leveraged and equipped to provide this information and refer to services accordingly.
Treasury Safety, Liquidity, and Money Premium Dynamics: Evidence from Debt Limit Impasses
Authors: CASHIN DAVID , FERRIS ERIN E. SYRON , KLEE ELIZABETH 
Published: December 2022

AbstractTreasury securities enjoy a “money premium” because they are ultra‐safe and liquid. However, during debt limit impasses, the safety and liquidity of Treasury securities temporarily deteriorate, eroding the money premium. Using past impasses, we find the money premium eroded by roughly six basis points across all Treasury securities and up to 50 basis points for the shortest maturities at the greatest risk of a delayed principal payment. Safety and liquidity each accounted for about half of the erosion. The deterioration of safety and liquidity also appears to interact, consistent with theories of default‐driven liquidity risk and the information sensitivity of debt.
The effect of tremor on disability assessment in chronic inflammatory demyelinating polyradiculoneuropathy
Authors: van Veen R. , Pallada G. , Wieske L. , Ten Holter S. E. M. , van Rootselaar A. F. , Verhamme C. , de Bie R. M. A. , van Schaik I. N. , Merkies I. S. J. , Dijk J. M. , Eftimov Filip 
Published: December 2022

AbstractTremor in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is common, often unresponsive to treatment, and may contribute to disability. We aim to investigate whether tremor is associated with disability as measured in daily practice and clinical trials, independent of other impairments. We included 76 CIDP patients in this cross‐sectional study. We assessed tremor with the Tremor Research Group essential tremor rating assessment scale (TETRAS) and the Fahn–Tolosa–Marin clinical rating scale (FTM). Disability was measured with the inflammatory Rasch‐built overall disability scale (I‐RODS) and the adjusted Inflammatory Neuropathy Cause and Treatment disability scale (INCAT‐DS, categorized separately in arm score, or total score). Impairments including strength, sensory impairment, and fatigue were measured using specific impairment scales. We tested whether “the presence of a clinically relevant tremor” (based on TETRAS and FTM) or “tremor severity” (FTM part B sum score) was associated with disability scores (I‐RODS, INCAT‐DS total score, and INCAT‐DS arm score), independent of the impairment scores, using multivariate regression. Both “the presence of a clinically relevant tremor” and “tremor severity” were significantly associated with disability measured by the INCAT‐DS (arm score and total score), but not the I‐RODS, independent of strength, sensory impairment, and fatigue. The explained variances were low. Clinically relevant tremor can (partly) explain disability in CIDP, as measured with the INCAT‐DS, independent of muscle strength, sensory deficits, and fatigue. To assess disease activity in CIDP patients with tremor, both impairment and disability outcomes should be assessed, as disability is caused partly by tremor while the effect of immunotherapy on tremor seems limited.
Rediscovering regional science: Positioning the field's evolving location in science and society
Authors: Chen Zhenhua , Schintler Laurie A. 
Published: December 2022

AbstractThis study aims to provide a comprehensive examination of the evolution of regional science, a scholarly domain in the social sciences that applies analytical and quantitative approaches and methods to understand and address urban, rural, or regional problems. We conducted a bibliometric analysis of 8509 articles published in six regional science flagship journals (including the Journal of Regional Science, Annals of Regional Science, Regional Science and Urban Economics, Papers in Regional Science, Regional Science Policy and Practice, and International Regional Science Review) from 1958 to 2021. The analysis presents an objective data‐driven and unprecedented visualization of the field's intellectual, social, and conceptual structure and trends from the beginning to the present. It also provides a rich portrayal of the epistemology of regional science and illuminates matters related to regional science education and training. We find that regional science has moved well beyond its origins, shifting away from a heavy focus on theory and abstraction to modeling/simulation, empirical analysis, and policy research. We also find that there has been increasing attention to “people” in regions and the spatial characteristics of social problems, and some important shifts in the regional science community itself, particularly in terms of patterns of collaboration and the geography of scholarship. The findings of this paper provide implications for future directions of research and education for regional science.
Predictive factors of exclusive breastfeeding attrition at Week 6 post‐partum among mothers of preterm infants based on the theory of planned behaviour
Authors: Huang Rong , Wan Yue , Yao Xiao , Wang Hao , Cai Chen‐ting , Xu Yi‐ting , Jiang Hui 
Published: December 2022

AbstractBreastfeeding plays an important role in the growth and development of preterm infants, and exclusive breastfeeding (EBF) in the first 6 weeks post‐partum is the key to continuous breastfeeding. This study was designed to explore the influencing factors that contribute to breastfeeding attrition among mothers of preterm infants at Week 6 post‐partum based on the theory of planned behaviour (TPB). We herein adopted a prospective observational study design in which 97 mothers who exclusively breastfed at Week 6 post‐partum at a tertiary specialised hospital in Shanghai from June 2021 to February 2022 were taken as the EBF group, and 179 mothers without EBF were assigned to the EBF attrition group. Through an extensive literature review and expert consultation, we determined the possible factors influencing EBF attrition, analysed those factors that showed statistical significance in our univariate analysis by applying binary logistic regression, and constructed a nomogram model for predicting EBF attrition. The results revealed that negative breastfeeding sentiment (odds ratio [OR] = 1.006; 95% confidence interval [CI], 1.000–1.011) generated a greater risk of breastfeeding attrition. However, positive breastfeeding sentiment (OR = 0.991; 95% CI, 0.983–0.999), social and professional support (OR = 0.993; 95% CI, 0.987–0.999), breastfeeding control (OR = 0.945; 95% CI, 0.896–0.996), knowledge (OR = 0.893; 95% CI, 0.799–0.998), and intention to EBF at Week 6 post‐partum (OR = 0.522; 95% CI, 0.276–0.988) were the protective factors and facilitated the development of our nomogram model. The Hosmer–Lemeshow goodness‐of‐fit test generated a χ2 value of 11.344 (p = 0.183) and an area under the curve of 0.822 (95% CI, 0.771–0.873). The C‐index was 0.800 in the internal bootstrap validation, indicating that the nomogram model possessed favourable predictive accuracy and discrimination.
A modal‐based Kalman filtering framework for mode extraction and decomposition of damped structures
Authors: Hwang Jae‐Seung , Kwon Dae Kun , Kareem Ahsan 
Published: December 2022

AbstractThe mode shape is one of the important modal parameters that enables to visualize the intrinsic behavior of a structure as well as the quantity of interest by extracting or separating modal response from measurements. In this study, a new output‐only framework is proposed to extract modes using a modal‐based Kalman filter defined in the modal space and identify the mode shape by manipulating the correlation between the separated modes and the measured responses. It is also shown that the proposed framework can be extended to estimate the mode shapes of a non‐classically damped structure in state space when the state variable is constructed from the measured responses and applied to the modal‐based Kalman filter. The mode shape estimation framework proposed in this study was verified by numerical simulations and full‐scale measurements. From the verification examples and their results, it was noted that the proposed modal identification framework is not influenced by the presence of noise, and it can be applied to identify the state‐space mode shapes of non‐classically damped systems as well as systems with very closely distributed modes such as buildings equipped with tuned mass dampers.
Testing the susceptibility of larval stages of Simulium to temephos and Bacillus thuringiensis var israelensis in Germany and Northern Cameroon
Authors: Kamtsap Pierre , Archile Paguem , Flore Nguemaïm , Njiokou Flobert , Renz Alfons 
Published: December 2022

AbstractAssays to evaluate the susceptibility of Simulium larvae to temephos and Bacillus thuringiensis var israelensis (Bti) were carried out by setting‐up an in vitro laboratory test (‘bio assay’) and a semi‐natural test (‘système de goutières’) to assess the LC50/LC90 values. Larvae of Simulium species in Cameroon (S. damnosum s.l., S. hargreavesi, S. vorax and S. cervicornutum) and (S. (Odagmia) ornatum and S. latipes) in Germany were identified and tested. In the bio‐assay, 50 larvae were exposed for 10 min to concentrations from 0.01 to 10 ppm. For the Simulium from Germany, the LC50 (LC90) values after 3 and 6 h were 3.1 (27.9) and 0.14 (1.26) ppm for temephos and for Bti 7.8 (70.2) and 1.7 (15.3) ppm, respectively. For Cameroonian species, the values of LC50 (LC90) were lower, that is, 0.42 (8.04), 0.14 (2.70) and 0.073 (1.38) ppm, respectively, after 3, 6 and 12 h for temephos. In a semi natural condition, the LC50 of 10 min of application of temephos was 0.84 ppm after 3 h and a working solution (2.6 L) of Bti killed 50% after 6 h. To detect an upcoming of any resistance as it happened in Ivory Coast, a study of the occurrence resistance genes should be implemented.
Framework of humanistic care for patients in theICU: A preliminary study
Authors: Zhang Yuchen , Zhao Li , Zhang Meng , Guo Xiaojing , Xin Chen , Gai Yubiao 
Published: December 2022

AbstractBackgroundHumanistic care involves caring, concern, paying attention to people's individuality, meeting their needs and respecting their rights, which is the core concept and central task of nursing. Effective care can enhance patients’ ability to deal with stress and promote patient recovery. Implementing humanistic care in the intensive care unit (ICU) is particularly important for health care providers.AimThis study aims to develop a framework of the humanistic care in theICU.Study DesignThe qualitative research followed Strauss' procedural grounded theory approach. Purposive sampling and theoretical sampling were used to select 12 nurses in the Department of Critical Medicine, 16 patients, and eight family members for semi‐structured interviews from October 2020 to April 2021. Results were summarized and analysed through three‐level coding based on grounded principles.ResultsSixteen subcategories and six main categories were extracted after three‐level coding, and the final ICU humanistic care framework was formed with home, activity, visit, environment, nursing and safety (“HAVENS”) as the core.ConclusionsThis study provides an explanatory theory of humanistic care in the ICU that can guide nurses' practice in ICU clinical work.Relevance to clinical practiceThis theory provides guidance for nurses to implement humanistic care in critical care practice to improve the ICU stay experience of critically ill patients.