bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic edematous-polypous laryngitis (Reinke – Gayek disease) as a cause of hoarseness. Personalized approach to the surgical treatment
Authors: Abdullaev B. Z. , Nazhmudinov I. I. , Davudov K. S. , Garashchenko T. I. , Guseynov I. G. , Khoranova M. Y. 
Published: December 2022

Introduction. Chronic edematous-polypous laryngitis, Reinke – Gayek’s edema accounts for 5.5% of all benign diseases of the vocal folds. Surgical treatment of Reinke – Gayek disease consists in removing excess mucosa, or “stripping” – tearing off a strip of mucosa with forceps from the vocal fold. The principle of laryngeal surgery is to preserve the structures of the vocal fold, to obtain flexible vibration of the muscular-membranous part and the mucous membrane of the vocal fold.Purpose. Improving the effectiveness of the treatment of patients with Reinke – Hayek edema by developing sparing methods of surgical treatment using a carbon dioxide laser. To develop criteria for choosing a method of sparing surgical treatment of Reinke – Hayek edema using a carbon dioxide laser, depending on the type of edema according to the Yonekawa classification.Materials and methods. 80 patients with Reinke – Gayek’s disease, 59 women and 21 men, from 29 to 77 years old, divided into two subgroups, and a control group were treated. Preoperative examination included endoscopic examination, laryngostroboscopy. The type was determined according to the H. Yonekawa classification. In type II, subgroup 1 – aspiration technique, n = 30. In type III, subgroup 2 – M-shaped technique, n = 30. Control group, it includes patients with type II and III edema, resection technique, n = 20.Results. Patients in the preoperative period were surveyed with the SF-36 Health Status Survey questionnaire, the dysphonia severity index (DSI), as well as the time of maximum phonation. In the postoperative period, they were examined, 1 month after the operation and 6 months after the operation. There is an increase in indicators, an increase in the time of maximum phonation, an increase in SF-36 scores.Conclusion. The use of this technique made it possible to significantly accelerate the recovery of the voice, reduce the time spent in the hospital, minimally damaging the structure of the mucous membrane of the vocal folds.
Update on Mesenchymal Stem Cells: A Crucial Player in Cancer
Immunotherapy
Authors: Taeb Shahram , Rostamzadeh Davoud , Mafi Sahar , Mofatteh Mohammad , Zarrabi Ali , Hushmandi Kiavash , Safari Arash , Khodamoradi Ehsan , Najafi Masoud 
Published: December 2022

Abstract:
The idea of cancer immunotherapy has spread, and it has made tremendous
progress with the advancement of new technology. Immunotherapy, which serves
to assist the natural defenses of the body in eradicating cancerous cells, is a remarkable
achievement that has revolutionized both cancer research and cancer treatments.
Currently, the use of stem cells in immunotherapy is widespread and shares a
special characteristic, including cancer cell migration, bioactive component release,
and immunosuppressive activity. In the context of cancer, mesenchymal stem cells
(MSCs) are rapidly being identified as vital stromal regulators of tumor progression.
MSCs therapy has been implicated in treating a wide range of diseases, including bone
damage, autoimmune diseases, and particularly hematopoietic abnormalities, providing
stem cell-based therapy with an extra dimension. Moreover, the implication of
MSCs does not have ethical concerns, and the complications known in pluripotent and
totipotent stem cells are less common in MSCs. MSCs have a lot of distinctive characteristics
that, when coupled, make them excellent for cellular-based immunotherapy
and as vehicles for gene and drug delivery in a variety of inflammations and malignancies.
MSCs can migrate to the inflammatory site and exert immunomodulatory responses
via cell-to-cell contacts with lymphocytes by generating soluble substances. In the
current review, we discuss the most recent research on the immunological characteristics
of MSCs, their use as immunomodulatory carriers, techniques for approving MSCs
to adjust their immunological contour, and their usages as vehicles for delivering therapeutic
as well as drugs and genes engineered to destroy tumor cells.
Serum Sirtuin-1, HMGB1-TLR4, NF-KB and IL-6 Levels in Alzheimer’s:
The Relation Between Neuroinflammatory Pathway and Severity of
Dementia
Authors: Gulmammadli Nazrin , Konukoğlu Dildar , Merve Kurtuluş Eda , Tezen Didem , Ibrahim Erbay Muhammed , Bozluolçay Melda 
Published: December 2022

aims:
We aimed to investigate the inflammatory pathways that lead to progressive neuronal loss and highlight their possible relationship with dementia severity by detecting these molecules in the systemic circulation.

background:
Since neuronal loss and neuropathological lesion formation reach an irreversible stage by the time of diagnosis, symptomatic treatments that are applied can only offer modest clinical outcomes. This necessitates the search for a marker or tool to diagnose and monitor the process accurately and easily.

objective:
In this study, serum Sirtuin-1(SIRT-1), High Mobility Group Box 1 (HMGB1), Toll-Like Receptor-4 (TLR4), Nuclear Factor kappa B (NF-kB), Interleukine-6 (IL-6), Amyloid βeta-42 (Aβ-42), and p-tau181 levels in patients diagnosed with AD according to NINCS-ADRA criteria were studied.

method:
Patients over 60 years of age were grouped according to their Standard Mini Mental Test, MRI, and/or Fludeoxyglucose positron emission tomography or according to their Computed Tomography findings as Control n:20; AD n:32; Vascular Dementia (VD) n:17; AD+VD;n=21. Complete blood count, Glucose, Vitamin B12, Folic Acid, Enzymes, Urea, Uric Acid levels, Creatinine, Electrolytes, Bilirubin, Thyroid Function tests, and Sedimentation rate were evaluated. ELISA kit method was used for the analysis of serum SIRT1, HMGB1, TLR4, NF-kB, IL-6, Aβ-42, and p-tau181 levels.

result:
Levels of serum Aβ-42, SIRT1, HMGB1, and IL-6 were significantly higher (p˂0.001, p&amp;amp;lt;0.01, p&amp;amp;lt;0.001, and p&amp;amp;lt;0.001, respectively), and TLR4 levels were significantly lower (p˂0.001) in the dementia group than in the control group. There was no significant difference between dementia and control groups for serum NF-kB and p-tau181 levels.

conclusion:
Our results show that the levels of the Aβ42, SIRT 1, HMGB1, and TLR4 pathways are altered in AD and VD. SIRT 1 activity plays an important role in the inflammatory pathway of dementia development, particularly in Alzheimer&amp;#039;s disease.

other:
This work is financially supported by Cerrahpaşa Scientific Research Projects Coordination Unit (BAPSİS)
Synthesis, ADMET Prediction, and Antitumor Profile of Phenoxyhydrazine-
1,3-thiazoles Derivatives
Authors: Leite Ana Cristina Lima , de Siqueira Lucianna Rabelo  Pessoa , de Lima Ferreira Larissa Pelágia , de  Oliveira Filho Gevanio Bezerra , de  Oliveira Marcos Victor Gregório , Pinto Aline Ferreira , de Melo  Silva Vanessa Gouveia , de Moraes Gomes Paulo André Teixeira , de Oliveira Cardoso Marcos Veríssimo , de Nazaré Correia Soeiro Maria , dos  Santos Flaviana Alves , da Rocha Pitta Maíra Galdino , Nunes Janine Siqueira , de Melo Rego Moacyr Jesus Barreto 
Published: December 2022

Background:
Cancer is one of the most important barriers to increasing life expectancy in all countries in the 21st century. Investigations of new anti-cancer drugs with low side effects are an urgent demand for medicinal chemists. Considering the known antitumor and immunomodulato-ry activity of thiazoles, this work presents the synthesis and antineoplastic activity of new thiazoles.

Method:
The 22 new compounds (2a-v) were synthesized from different thiosemicarbazones and 2-bromoacetophenone. The compounds were evaluated on: MOLT-4, HL-60, HL-60/MX1, MM1S, SKMEL-28, DU145, MCF-7, and T47d.

Result:
Compound 2b induced cellular viability on MOLT-4 (37.1%), DU145 (41.5%), and HL-60/MX1 (58.8%) cells. On MOLT-4 cells, compound 2b exhibited an IC50 of 8.03 μM, and against DU145 cells, an IC50 of 6.04μM. Besides, at IC50 and fold of IC50, 20% to 30% of dead cells were found, most due to necrosis/late apoptosis. Most compounds no showed cytotoxicity against fibro-blast cells L929 at the concentrations tested. The compound did not alter the cell cycle of DU145 cells when compared to the negative control. Therefore, compound 2b stands out against DU145 and MOLT-4 cells.

Conclusion:
Our study reinforced the importance of 1,3-thiazoles nuclei in antitumor activity. In addition, derivative 2b stands out against DU145 and MOLT-4 cells and could be a starting point for developing new antineoplastic agents.
Piezoelectric Biosensors and Nanomaterials-based Therapeutics for Coronavirus
and Other Viruses: A Mini-review
Authors: Bhaskar Rakesh , Han Sung Soo , Ramasamy Madeshwaran Sekkarapatti 
Published: December 2022

Abstract:
Since late 2019, the novel coronavirus (COVID-19) pandemic has caused considerable mortality worldwide. This pandemic raised concerns and provoked research on the diagnosis and treatment of viruses-based diseases. The accurate diagnosis of a virus requires high specificity and sensitivity. Piezoelectric sensors are analytical devices that work on mass-sensitivity-based micro-mechanical transducers. The change in the mass by the interaction between biological elements and the frequency is recorded by measuring the alternate current and voltage. In addition to diagnosis, antiviral intervention strategies for mitigating various viral diseases are required. Nanomaterials-based antiviral therapy is efficient, particularly with carbon/metal/metal oxide (organic/inorganic) nanoparticles. Metal/metal oxide nanoparticles, such as gold (Au), silver (Ag), copper (Cu), seleni-um (Se), zinc oxide (ZnO), magnesium oxide (MgO), carbon dots (CDs), and carbon quantum dots (CQDs), are promising candidates for antiviral therapy. This review discusses the piezoelectric sen-sors used to detect various viruses, including COVID-19, and the various organic and inorganic na-noparticles involved in the antiviral therapy.
Nutritional and Medicinal Value of Red Rice
Authors: Kothapalli Lata , Kale Sakshi , Dharade Monika , Thomas Asha , Godse Anagha 
Published: December 2022

Background:
Various varieties of rice (Oryza sativa) have been exploited for a variety of
purposes since ancient times, with the integration into foods, cosmetics, and pharmaceutical products.
A huge diversity is seen in the cultivated rice variety based on regions, area, and climatic conditions
responsible for variation in chemical composition leading to enriched supplements beneficial
for health conditions. Among the varieties available, red rice extract is now increasingly recognized
for its antioxidant, anti-inflammatory activity, anti-diabetic, anti-hyperlipidemic activity, and bone
formation.

Objective:
There is a need to validate the nutritional and supplement values through appropriate analytical
and pharmacological studies and create awareness for the end users regarding the value of
red rice.

Results:
In the present article attempt is done to reviewthe variety of red rice based on geographical
origin, and the impact on nutritional and medicinal value. Further elaborating the extraction techniques
which can help optimize the extraction efficiency of polyphenols known for their antioxidant
properties. Polyphenolic phytoconstituents belonging to phenolic acids, and flavonoids include, flavonols,
flavones, flavanols, flavanones, and isoflavones, to name a few. Anthocyanins, and proanthocyanidins
make the pigment part of the outer layer and bran of the rice and contain the monomers
of catechin, epicatechin, gallocatechin, and epigallocatechin units. The quantification of the
phytoconstituents using chromatographical methods can help in evaluation of the red rice for its
quality and design formulation with desired efficacy.

Conclusion:
With the vast varieties of red rice available, quantification of important bio-actives
can help in maintaining quality of final product. Various targeted pharmacological actions reported
include anti-inflammatory, antihyperlipidemic, antidiabetic, anticancer and antioxidant produced by
the rice, mainly by virtue of the polyphenolic content, contribute in achieving a value to rice as
nourishment and a safe therapeutic product which can be consumed as a nutraceutical or pharmaceutical
ingredient.
Studi Perencanaan Ulang Bendung di Daerah Irigasi Rawaan Kabupaten Lumajang Jawa Timur
Authors: Purwanto Harjuna Arif , Suprijanto Heri , Prayogo Tri Budi 
Published: December 2022

Bendung Rawaan merupakan bangunan utama yang berperan memenuhi kebutuhan air lahan irigasiÂ seluas 354,10 ha di Daerah Irigasi Rawaan. Rusaknya sebagian besar dari Bendung Rawaan menyebabkan lahan irigasi seringkali tidak terairi sepenuhnya, terutama saat musim kemarau. Untuk mengoptimalkan fungsi bangunannya, maka diperlukan perencanaan ulang berdasarkan analisis hidrologi, hidrolika, stabilitas, dan desain penulangan. Dimensi bangunan utama Bendung Rawaan ditentukan berdasarkan analisis hidrologi debit banjir kala ulang 100 tahun (Q100) HSS Gama I sebesar 318,51 m3/detik. Direncanakan dimensi mercu Bendung Rawaan memiliki tinggi 1,60 m dan lebar 25,60 m. Peredam energi menggunakan tipe bucket untuk mencegah terjadinya kerusakan peredam energi akibat gaya hantam dari sedimen sungai berupa batuan bolder. Berdasarkan desain hidrolis, pemilihan tipe bucket juga mengurangi kemungkinan terjadinya gerusan lokal di hilir bangunan. Keamanan struktur bangunan dinyatakan aman berdasarkan analisis rembesan dan stabilitas dalam keadaan normal dan gempa. Bendung Rawaan didesain menggunakan beton K-175 yang dilapisi selimut beton bertulang K-300.
Studi Alternatif Perencanaan Rainwater Harvesting Pada Apartemen Westpoint Jakarta Barat
Authors: Maulana Firhand , Haribowo Riyanto , Sholichin Moh. 
Published: December 2022

Penelitian ini bertujuan untuk mengetahui berapa potensi air hujan yang dapat digunakan sebagai alternatif sumber air pada Apartemen Westpoint dan juga merencanakan anggaran biaya pada perencanaan pemanenan air hujan di Apartemen Westpoint. Pada penelitian ini untuk area tangkapan air hujan menggunakan 3 area. Dari hasil 3 area tangkapan maka diperoleh air hujan yang dapat di tampung pada Apartemen Westpoint yaitu sebesar 34 m3/hari dengan luas area tangkapan sebesar 1,500 m2. Tampungan pada perencanaan ini menggunakan 2 tampungan yaitu ground water tank dan roof tank dengan masing-masing kapasitasnya sebesar 34 m3 dan 4.6 m3. Pada perhitungan kebutuhan air berdasarkan jenis alat plambing pada lantai 1 sampai 3Â didapatkan sebesar 17,366 m3/hari Setelah dilakukan analisa maka kebutuhan air untuk kegiatan menyiram toilet dan bak cuci tangan biasa pada lantai 1 sampai 3 dapat terpenuhi, dengan penghematan sebesar Rp 217.868 / hari yang akan menguntungkan pihak pengelola Apartemen Westpoint. Sedangkan untuk rancangan anggaran biaya perencanaan pemanenan air hujan pada Apartemen Westpoint ini sebesar Rp 292.471.563.
Perspectives on Promoting Physical Activity Using eHealth in Primary Care by Health Care Professionals and Individuals With Prediabetes and Type 2 Diabetes: Qualitative Study
Authors: Woldamanuel Yohannes , Rossen Jenny , Andermo Susanne , Bergman Patrik , Åberg Linda , Hagströmer Maria , Johansson Unn-Britt 
Published: December 2022

Background
The trend of an exponential increase in prediabetes and type 2 diabetes (T2D) is projected to continue rising worldwide. Physical activity could help prevent T2D and the progression and complications of the disease. Therefore, we need to create opportunities for individuals to acquire the necessary knowledge and skills to self-manage their chronic condition through physical activity. eHealth is a potential resource that could facilitate self-management and thus improve population health. However, there is limited research on users’ perception of eHealth in promoting physical activity in primary care settings.

Objective
This study aims to explore the perspectives of health care professionals and individuals with prediabetes and T2D on eHealth to promote physical activity in primary care.

Methods
A qualitative approach was applied using focus group discussions among individuals with prediabetes or T2D (14 participants in four groups) and health care professionals (10 participants in two groups). The discussions were audio-recorded and transcribed verbatim. Qualitative content analysis was used inductively to code the data.

Results
Three main categories emerged: utility, adoption process, and accountability. The utility of eHealth was described as a motivational, entertaining, and stimulating tool. Registration of daily medical measurements and lifestyle parameters in a cohesive digital platform was recognized as a potential resource for strengthening self-management skills. The adoption process includes eHealth to increase the accessibility of care and personalize the support of physical activity. However, participants stated that digital technology might only suit some and could increase health care providers’ administrative burden. Accountability refers to the knowledge and skills to optimize eHealth and ensure data integrity and security.

Conclusions
People with prediabetes and T2D and health care professionals positively viewed an integration of eHealth technology in primary care to promote physical activity. A cohesive platform using personal metrics, goal-setting, and social support to promote physical activity was suggested. This study identified eHealth illiteracy, inequality, privacy, confidentiality, and an increased workload on health care professionals as factors of concern when integrating eHealth into primary care. Continuous development of eHealth competence was reported as necessary to optimize the implementation of eHealth technology in primary care.
Improvements in Glycemic Control and Depressive Symptoms Among Adults With Type 2 Diabetes: Retrospective Study
Authors: Venkatesan Aarathi , Zimmermann Gretchen , Rawlings Kelly , Ryan Claudia , Voelker Louise , Edwards Caitlyn 
Published: December 2022

Background
The prevalence of diabetes remains high, with traditional lifestyle interventions demonstrating limited success in improving diabetes-related outcomes, particularly among individuals with diabetes-related mental health comorbidities. Digital health interventions provide the ability to ease the sustained and rigorous self-management needs associated with diabetes care and treatment. Current interventions though, are plagued by small sample sizes, underpowered pilot studies, and immense heterogeneity in program intervention, duration, and measured outcomes.

Objective
Therefore, this work aimed to evaluate the effectiveness of a mobile health diabetes management program on measures of glycemic control in a high-risk population with type 2 diabetes (hemoglobin A1c [HbA1c] ≥8.0%), utilizing a sample of 1128 participants who provided baseline and follow-up data. The sustainability of this change in glycemic control was examined in a subset of participants (n=455) at 6 months and 1 year following program enrollment. A secondary analysis examined changes in glycemic control among a subset of participants with self-reported mild-to-moderate depression at baseline.

Methods
This study utilized a single-arm, retrospective design. Participants were enrolled in the Vida Health Diabetes Management Program. This app-based intervention utilized one-on-one remote sessions with a health coach, registered dietitian nutritionist, and/or a certified diabetes care and education specialist and structured lessons and tools related to diabetes management and self-care. Participants provided baseline (–365 to 21 days of program enrollment) as well as follow-up (at least 90 days following program enrollment) HbA1c values. Paired t tests were used to evaluate changes in HbA1c between baseline and follow-up time points. The 8-item Patient Health Questionnaire and the 7-item Generalized Anxiety Disorder Scale were utilized to assess self-reported depressive and anxiety symptoms, respectively. Paired t tests and linear regression modeling accounting for pertinent covariates were used to evaluate changes in mental health symptom acuity and their relationship with changes in glycemic control.

Results
We observed a significant decrease in HbA1c of –1.35 points between baseline (mean 9.84, SD 1.64) and follow-up (mean 8.48, SD 1.77; t=22.56, P<.001) among this large, high-risk sample. This decrease was sustained up to 1 year following program enrollment. Additionally, a significant relationship between improvements in depressive symptom acuity and improvements in HbA1c was observed (β=–0.74, P=.03).

Conclusions
This study demonstrates clinically meaningful improvements in glycemic control among participants enrolled in the Vida Health Diabetes Management Program. Additionally, this work presents one of the largest studied samples of participants enrolled in a digital health diabetes management program to date.
Development of Open Backend Structures for Health Care Professionals to Improve Participation in App Developments: Pilot Usability Study of a Medical App
Authors: Dittrich Florian , Albrecht Urs-Vito , Scherer Julian , Becker Sören L , Landgraeber Stefan , Back David Alexander , Fessmann Kai , Haversath Marcel , Beck Sascha , Abbara-Czardybon Mona , Quitmann Henning , Harren Anna Katharina , Aitzetmüller Matthias , Klietz Marie Luise 
Published: December 2022

Background
Efficient digitization in medicine still is in its infancy but undeniably has great potential for current and future challenges in health care. Thus far, the rollout of medical apps has not resulted in widespread use of smartphones in the German health care sector—the reasons for this have not been clarified so far. Nevertheless, the lack of user involvement in the development process and content creation might contribute to low acceptance of these products.

Objective
This study aims to outline an approach to involve medical expertise without any coding knowledge for developing medical app content and functions.

Methods
An end user–operable backend was built. Its usability was evaluated using a usability evaluation test protocol. The results of the usability tests were evaluated by the app development team, and the usability test was repeated for optimizing backend usability. In total, 40 criteria to measure the ease of app usage were defined a priori. The usability test comprised 20 tasks that had to be fulfilled. Usability tasks were analyzed for completion, dropout, and test duration. Due to the COVID-19 pandemic, digital videoconferencing platforms (Zoom and QuickTime Player) were used to complete usability questionnaires. Finally, several backend-based apps for several specialties (infectiology, plastic and reconstructive surgery, and orthopedics) were developed by health care professionals as prototypes.

Results
Initial usability testing was conducted with 5 participants (4 men and 1 woman; mean age 39.2, SD 5.97 years). All of them could complete the assigned backend tasks with only a few workflow interruptions and some minor errors. After usability optimization, the workflow completion time decreased from 5.03 minutes to 3.50 minutes, indicating a time saving. The basic backend structure was clear to all test users and the handling was intuitive to learn. Some minor errors in the backend occurred during the test rounds. The apps developed using the aforementioned approach are in clinical use as a proof of concept.

Conclusions
Backends offering operability for medical professionals might have great potential for app development in the mobile health sector. Sophisticated and time-saving usability are pivotal for the acceptance of medical software, as illustrated by the backend-based apps presented herein, which are in clinical use as a proof of concept. Basic interventions are essential and sufficient for adequate usability optimization. Practicable, well-structured software usability evaluation is possible based on the usability evaluation test protocol.