bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ciprofloxacin Derivative‐Loaded Nanoparticles Synergize with Paclitaxel Against Type II Human Endometrial Cancer
Authors: Naguib Youssef W. , Alhaj‐Suliman Suhaila O. , Wafa Emad I. , Saha Sanjib , Ebeid Kareem , Mohammed Hamada H. H. , Abdel‐Rahman Somaya A. , Abuo‐Rahma Gamal El‐Din A. , Geary Sean M. , Salem Aliasger K. 
Published: August 2023

AbstractCombinations of chemotherapeutic agents comprise a clinically feasible approach to combat cancers that possess resistance to treatment. Type II endometrial cancer is typically associated with poor outcomes and the emergence of chemoresistance. To overcome this challenge, a combination therapy is developed comprising a novel ciprofloxacin derivative‐loaded PEGylated polymeric nanoparticles (CIP2b‐NPs) and paclitaxel (PTX) against human type‐II endometrial cancer (Hec50co with loss of function p53). Cytotoxicity studies reveal strong synergy between CIP2b and PTX against Hec50co, and this is associated with a significant reduction in the IC50 of PTX and increased G2/M arrest. Upon formulation of CIP2b into PEGylated polymeric nanoparticles, tumor accumulation of CIP2b is significantly improved compared to its soluble counterpart; thus, enhancing the overall antitumor activity of CIP2b when co‐administered with PTX. In addition, the co‐delivery of CIP2b‐NPs with paclitaxel results in a significant reduction in tumor progression. Histological examination of vital organs and blood chemistry was normal, confirming the absence of any apparent off‐target toxicity. Thus, in a mouse model of human endometrial cancer, the combination of CIP2b‐NPs and PTX exhibits superior therapeutic activity in targeting human type‐II endometrial cancer.
A bibliometric analysis of Agile software development publications originating from Turkey
Authors: Ozkan Necmettin , Gurgen Erdogan Tugba , Bal Sevval , Gök Mehmet Şahin 
Published: August 2023

AbstractAgile software development has reached wide adoption in various countries including Turkey, even though from which its original cultural backgrounds differ. In Turkey, many organizations have started to adopt Agile approaches more and more in their software development processes. This interest in the country's software development is parallel to what the academic literature on Agile in the country exhibits. However, despite the prevalence of Agile in Turkey, there is a lack of sufficient secondary research and comprehensive review on Agile in Turkey, which poses a significant necessity for further investigation. Considering this gap, we performed a quantitative bibliometric analysis of Agile software development publications produced by Turkish organizations in a holistic and broad approach both for scholars and practitioners. We provide a summary of relevant academic studies that emerged in Agile research in Turkey by focusing on many aspects including bibliometric properties of papers, researchers, affiliations, venues, and thematic contents that are separated into 15 sub‐research questions. After delivering results based on the questions, we discuss the results and findings of our study and present implications regarding the findings. The main contributions of our work are twofold. First, the paper may help the readers to have a quick idea, understand the subject, and gain insight from a large volume of scientific data. Second, the paper can help readers to use these analyses to form future research.
Experimental study of moment redistribution before yielding in precast prestressed concrete beams made continuous
Authors: Kytölä Ulla , Tulonen Joonas , Asp Olli , Nakari Tarja , Laaksonen Anssi 
Published: August 2023

AbstractThe bending stiffness distribution of beams composed of simple‐span precast prestressed beams, which are made continuous by deck reinforcement at intermediate supports, is not constant. As the structure undergoes loading, the deck slab at the intermediate support cracks earlier than the prestressed span soffit and due to that the bending stiffness distribution changes along the beam length. The effect of nonconstant bending stiffness distribution on the moment redistribution of the structure before the yielding is studied experimentally and analytically. Two continuous beams with spans of 10 m + 10 m were manufactured, loaded to failure, and studied. It was concluded that the studied structure undergoes considerable moment redistribution before yielding although it would be designed for zero redistribution at the ultimate limit state. If this elastic redistribution is neglected in the structural analysis, the service limit state sagging moment at midspan may end up on the unconservative side. Elastic redistribution can be predicted quite accurately with the help of nonlinear analysis or roughly with simplified idealization as proposed in this article.
Main water pathways in cultivated clayey calcisols in molassic hills in southwestern France: Toward spatialization of soil waterlogging
Authors: Trochon Benjamin , Bustillo Vincent , Caner Laurent , Pasquet Sylvain , Suc Virginie , Granouillac Franck , Probst Anne , Probst Jean‐Luc , Tallec Tiphaine , Guiresse Maritxu 
Published: August 2023

AbstractLocal waterlogging often occurs on the steep slopes of clayey–calcareous soils in southwestern France, causing nutrients and pollutants transfer to the river bodies and reduced ecosystems services. These soils developed in the Miocene molassic hill formation and are generally impermeable with abundant traces of hydromorphy and heterogenous spatial distribution. This article aims to describe the hydrological functioning of these soils, based on a cross analysis of pedological, hydrological, and geophysical characterizations. Our experimental site is the catchment area located in Auradé (southwestern France). Here, we analyze the flows at the outlet of the studied watershed together with piezometric and climatic monitoring from September 2020 to September 2021. We show that the hydrological year is divided into three phases: first, a soil recharge phase with an effective rainfall of about 100 mm; second, a saturation phase, when 80% of the effective precipitation is drained mostly by runoff and hypodermic flows; third, a drying phase. Soil waterlogging events usually occur during the saturation phase. They are due to several forms of flow: surface runoff associated with return flow, hypodermic flow caused by the presence of soil layers with lower hydraulic conductivity in the subsurface (swelling clays and plowing sole) and groundwater flow with intermittent connection of the soil water table in the hillside to the alluvial groundwater table. We also conducted independent seismic refraction tomography analyses that validate localized waterlogging patterns along the catchment and open the way to spatializing areas with high waterlogging potential at the scale of the study plot.
Portable x‐ray fluorescence as a tool for assessing electric marks in forensic evaluation
Authors: Tambuzzi Stefano , Bonizzoni Letizia , Di Paola Francesco , Mazzarelli Debora , Caccia Giulia , Cattaneo Cristina 
Published: August 2023

AbstractPortable x‐ray fluorescence (XRF) is a reliable, rapid and noninvasive technique. Recently, it has been used in a wide variety of fields where the sample must still be available after examination or when qualitative information on chemical composition is needed quickly to perform more detailed studies. These properties also make it suitable for forensic investigations, as shown by some recent reports. In the present work, a systematic evaluation of metal micro traces in electric marks was performed in a case of death by electrocution (high‐voltage current). The results are promising, as XRF has been shown to be a suitable tool not only for skin fragments but also for graphite adhesive tapes placed on the body skin areas of forensic interest and then analyzed. The latter finding proves that skin samples at autopsy are not the only valuable sampling method, thus paving the way for the application of XRF in the diagnosis of electrical injuries in living individuals as well.
Ausblick
Authors: Heine Moreen , Dhungel Anna-Katharina , Schrills Tim , Wessel Daniel 
Published: August 2023

ZusammenfassungMit Blick auf die Nutzung KI-basierter Lösungen befinden wir uns derzeit in einer frühen Phase mit wenigen Pilotanwendungen. Eine besondere Herausforderung liegt in der Identifikation geeigneter Anwendungsfelder. Diese Technologieorientierung ist in der Erprobungsphase nachvollziehbar, geht jedoch häufig an den Problemen und Anforderungen der Verwaltungspraxis vorbei. Es besteht die Gefahr, dass alternative Lösungsansätze vernachlässigt werden.
Mixed graviton and scalar bispectra in the EFT of inflation: Soft limits and Boostless Bootstrap
Authors: Ghosh Diptimoy , Panchal Kushan , Ullah Farman 
Published: August 2023

Abstract
Boostless Bootstrap techniques have been applied by many in the literature to compute pure scalar and graviton correlators. In this paper, we focus primarily on mixed graviton and scalar correlators. We start by developing an EFT of Inflation (EFToI) with some general assumptions, clarifying various subtleties related to power counting. We verify explicitly the soft limits for mixed correlators, showing how they are satisfied for higher derivative operators beyond the Maldacena action. We clarify some confusion in the literature related to the soft limits for operators that modify the power spectra of gravitons or scalars. We then proceed to apply the boostless bootstrap rules to operators that do not modify the power spectra. Towards the end, we give a prescription that gives correlators for states that are Bogolyubov transforms of the Bunch-Davies vacuum, directly once we have the correlator for the Bunch-Davies vacuum. This enables us to bypass complicated in-in calculations for Bogolyubov states.
α′ corrections to KPV: an uplifting story
Authors: Schreyer Simon , Venken Gerben 
Published: August 2023

Abstract
In earlier work, the effect of α′2 curvature corrections on the NS5-brane responsible for the decay of anti-D3-branes in the set-up of Kachru, Pearson, and Verlinde (KPV) was considered. We extend this analysis to include all known α′2 corrections to the action of an abelian fivebrane which involve not just curvature but also gauge fields and flux. We compute the value of these terms at the tip of the Klebanov-Strassler throat to obtain the α′2 corrected potential for the NS5-brane of KPV. The resulting potential provides a novel uplifting mechanism where one can obtain metastable vacua with an arbitrarily small positive uplifting potential by fine-tuning α′ corrections against the tree-level potential. This mechanism works for small warped throats, both in terms of size and contribution to the D3-tadpole, thereby sidestepping the issues associated with a standard deep warped throat uplift which are deadly in KKLT and, as we explicitly check, severely constraining in the Large Volume Scenario.
New computational tools for chemical kinetics: the Cathedral Package
Authors: Ferro-Costas David , Fernández-Ramos Antonio 
Published: August 2023

AbstractThe advent of recent technological developments in software engineering has enabled the exploration of reaction mechanisms inside intricate reaction networks, thereby propelling the beginning of a new era in ab initio kinetics. While it is feasible to consider a substantial number of reactions, determining their rate constants with precision remains an arduous task, even for gas-phase processes. The difficulties are attributed not only to the inherent limitations in the calculation methodology but also to the manual labor and extensive chemical dynamics required, rendering these calculations inaccessible to the general public. As such, there is a pressing need for the development of automated codes and user-friendly interfaces to address this limitation. The present work focuses on the introduction of the Cathedral package, a unified computational code comprising the , , and programs. This package serves to bridge the gap between theoretical studies in chemical kinetics and non-specialist users, making it more accessible and user-friendly.
Pump-probe reflectivity studies of ultrashort laser-induced acousto-mechanical strains in ZnO films
Authors: Kosma Kyriaki , Kaleris Konstantinos , Kaselouris Evaggelos , Kaniolakis-Kaloudis Emmanouil , Petrakis Stylianos , Orphanos Yannis , Gagaoudakis Emmanouil , Binas Vassilis , Bakarezos Efthimios , Tatarakis Michael , Dimitriou Vasilis , Papadogiannis Nektarios A. 
Published: August 2023

AbstractIn the current work we report on the generation of acoustic strains in thin ZnO layers using optoacoustic transduction of ultrashort laser pulses into acoustic waves on an Au thin film transducer. After absorption of energy by the electron system of the metal, energy conversion, thermal expansion and mechanical deformation takes place. The generation and propagation of the induced acoustic strains are monitored in time via a degenerate pump-probe transient reflectivity optical setup at 800 nm, as opposed to most commonly used schemes that employ different wavelengths for the pump and probe beams, mostly in the vicinity of ZnO maximum absorption. The experimental results include energy relaxation times and phonon scattering frequencies and are supported by a thermal vibro-acoustic finite element model. The model is based on the combination of a revised two-temperature approach and elasticity theory, and considers anisotropic properties for the ZnO film and the computation of the elastic wave velocity for the first time. The outcomes are discussed in the context of electron–phonon coupling factors and other material properties. A good agreement between the experimental findings and the results from the numerical simulations has been established, regarding outcomes like the mean velocity of the strain waves, establishing a novel characterization method applicable to a variety of materials and structures.
The impact of 2 weeks wait referral on survival of head and neck cancer patients
Authors: Rovira Aleix , Russell Beth , Trivedi Priyanka , Ojo Onaiho , Oakley Richard , Byrne Edie , Daryanani Avisha , Van Hemelrijck Mieke , Simo Ricard 
Published: August 2023

Abstract
Purpose
This study aims to evaluate the association between 2 weeks wait referral and survival in the head and neck cancer.

Methods
Retrospective cohort study of consecutively discussed new head and neck cancer patients at large United Kingdom Cancer Alliance including two tertiary referral hospitals and two district general hospital.

Results
A total of 276 cancer patients were included for analysis. Patients referred under the 2 weeks wait had were seen and diagnosed sooner from referral (p < 0.0001 and p < 0.0001 respectively). However, this did not translate into better survival outcomes. No survival differences were seen between those patients that were managed within the proposed cancer targets and those that were not.

Conclusions
The 2 weeks wait head and neck cancer pathway did not offer a survival advantage. Targeting the delay in referral as well as delay in treatment to prevent late-stage cancer presentation is paramount. Fulfilment of cancer time targets do not translate into better outcomes and should not be prioritised to clinical judgement.
Resilience as a predictor of habituation
Authors: Rösner Christoph , Tüscher Oliver , Petrowski Katja 
Published: August 2023

AbstractHabituation refers to the physiological adaptation to recurrent stressors, which can be measured by cortisol levels, and is considered a central mechanism in reducing allostatic load. Resilience, a potential factor influencing stress reduction, is the focus of this study. Specifically, the study aims to investigate the impact of resilience, as assessed by the Brief Resilience Scale (BRS), on habituation. The Trier Social Stress Test (TSST) was used as the recurrent stressor, and it was administered to each of the 56 subjects at 4 consecutive measurements. To assess habituation, various physiological parameters including the area under the curve with respect to the ground (AUCg) and with respect to the increase (AUCi), cortisol peak, slope from baseline to peak, and recovery were calculated. Mixed linear models were employed to examine the differences in the influence of resilience on habituation across the different time points. The findings indicate that the influence of resilience significantly varies from the first to the fourth measurement time point for AUCg (p = .048), while no significant differences were observed for the other cortisol parameters. The effects plot suggests that individuals with higher levels of resilience exhibit lower AUCg values throughout the measurements. These findings provide initial evidence supporting resilience as a predictor of cortisol habituation. However, future studies should also consider dynamic resilience models, utilizing longitudinally assessed resilience as a predictor for habituation, to explore whether resilience acts as a determinant of habituation or if habituation itself constitutes a resilience mechanism.
Modeling spatial dependencies of natural hazards in coastal regions: a nonstationary approach with barriers
Authors: Chaudhuri Somnath , Juan Pablo , Saurina Laura Serra , Varga Diego , Saez Marc 
Published: August 2023

AbstractNatural hazards like floods, cyclones, earthquakes, or, tsunamis have deep impacts on the environment and society causing damage to both life and property. These events can cause widespread destruction and can lead to long-term socio-economic disruption often affecting the most vulnerable populations in society. Computational modeling provides an essential tool to estimate the damage by incorporating spatial uncertainties and examining global risk assessments. Classical stationary models in spatial statistics often assume isotropy and stationarity. It causes inappropriate smoothing over features having boundaries, holes, or physical barriers. Despite this, nonstationary models like barrier model have been little explored in the context of natural disasters in complex land structures. The principal objective of the current study is to evaluate the influence of barrier models compared to classical stationary models by analysing the incidence of natural disasters in complex spatial regions like islands and coastal areas. In the current study, we have used tsunami records from the island nation of Maldives. For seven atoll groups considered in our study, we have implemented three distinct categories of stochastic partial differential equation meshes, two for stationary models and one that corresponds to the barrier model concept. The results show that when assessing the spatial variance of tsunami incidence at the atoll scale, the barrier model outperforms the other two models while maintaining the same computational cost as the stationary models. In the broader picture, this research work contributes to the relatively new field of nonstationary barrier models and intends to establish a robust modeling framework to explore spatial phenomena, particularly natural hazards, in complex spatial regions having physical barriers.
Temperature–humidity index monitoring during two summer seasons in dairy cow sheds in Mugello (Tuscany)
Authors: Messeri Alessandro , Mancini Marco , Bozzi Riccardo , Parrini Silvia , Sirtori Francesco , Morabito Marco , Crisci Alfonso , Messeri Gianni , Ortolani Alberto , Gozzini Bernardo , Orlandini Simone , Fibbi Luca , Cristofori Simone , Grifoni Daniele 
Published: August 2023

AbstractMany studies have reported that the impact of high temperatures affects physiology, welfare, health, and productivity of farm animals, and among these, the dairy cattle farming is one of the livestock sectors that suffers the greatest effects. The temperature–humidity index (THI) represents the state of the art in the evaluation of heat stress conditions in dairy cattle but often its measurement is not carried out in sheds. For this reason, the aim of this study was the monitoring of the THI in three dairy cattle farms in Mugello (Tuscany) to understand its influence on dairy cows. THI values were calculated using meteorological data from direct observation in sheds and outdoor environments. Data relating to the animal’s behavior were collected using radio collars. The Pearson test and Mann–Kendall test were used for statistical analysis. The results highlighted a significant (P< 0.001) upward trend in THImax during the last 30 years both in Low Mugello (+ 1.1 every 10 years) and in High Mugello (+ 0.9 every 10 years). In Low Mugello sheds, during the period 2020–2022, more than 70% of daytime hours during the summer period were characterized by heat risk conditions (THI > 72) for livestock. On average the animals showed a significant (P< 0.001) decrease in time spent to feeding and rumination, both during the day and the night, with a significant (P< 0.001) increase in inactivity. This study fits into the growing demand for knowledge of the micro-climatic conditions within farms in order to support resilience actions for protecting both animal welfare and farm productivity from the effects of climate change. This could also be carried out thanks to estimation models which, based on the meteorological conditions forecast, could implement the thermal stress indicator (THI) directly from the high-resolution meteorological model, allowing to get a prediction of the farm’s potential productivity loss based on the expected THI.
The impact of electronic and conventional cigarettes on periodontal health—a systematic review and meta-analysis
Authors: Thiem Daniel G. E. , Donkiewicz Phil , Rejaey Raha , Wiesmann-Imilowski Nadine , Deschner James , Al-Nawas Bilal , Kämmerer Peer W. 
Published: August 2023

Abstract
Objectives
This systematic review and meta-analysis examined the effects of electronic cigarettes on periodontal health compared to conventional cigarette smoke and a non-smoking population.

Materials and methods
MEDLINE, Embase, Web of Science, CENTRAL, and ClinicalTrials.gov were screened for literature. Eligibility criteria included clinical studies published between 2006 and 2022 that compare e-cigarettes and conventional cigarettes on periodontal health (bleeding on probing (BoP), plaque index (PI), probing depth (PD), attachment loss (AL), marginal bone loss (MBL), tooth loss, molecular inflammation markers, salivary flow rate). Meta-regression analysis was used to examine the influence of moderator variables.

Results
Sixteen studies were found to be eligible for qualitative synthesis. Individual analyses showed that cigarette smokers had significantly higher PI, PD, AL, and MBL and increased concentrations of proinflammatory mediators than e-cigarette users and non-smokers. Meta-analysis revealed a 0.33-fold lower chance for BoP in e-cigarette users compared to smokers (p = 0.03), whereby meta-regression failed to detect any effects regarding the age of users and frequency of smoking. A 0.01-fold decreased chance for positive BoP in e-cigarette users compared with non-smokers was seen (p < 0.01).

Conclusions
The current findings suggest that that e-cigarette use might be considered a healthier alternative to cigarette smoking concerning periodontal health. Even so, harmful effects of electronic nicotine delivery system (ENDS) usage on periodontal health were seen as well. However, a definitive decision on this research question remains elusive due to the absence of randomized controlled trials.

Clinical relevance
Electronic cigarettes, marketed as a safer alternative to traditional cigarettes, are becoming increasingly popular. Evidence on the use of electronic cigarettes as a cessation aid and its beneficial impact compared to cigarette smoke remains inconclusive, so the analysis conducted in this review addresses a recent question of high clinical relevance.