bluuebunny/crossref_metadata_2025_split huggingface dataset:
WEE1 kinase inhibition triggers severe chromosome pulverization in aneuploid cells
Authors: Haykal Maria M. , Rodrigues-Ferreira Sylvie , Nahmias Clara 
Published: September 2023

AbstractAneuploidy, a hallmark of cancer, is a prominent feature associated with poor prognosis in breast cancer. Here, we screened a panel of cell cycle kinase inhibitors to identify novel targets for highly aneuploid breast cancers. We show that increasing aneuploidy in breast cancer cells sensitizes to the inhibition of WEE1 kinase. Upon exposure to WEE1 inhibitor, aneuploid cells exhibit aberrant mitosis characterized by the detachment of centromere proteins from centromeric DNA and pulverization of chromosomes. The occurrence of such phenotype is driven by excessive levels of replication stress and DNA damage during S-phase, that in turn trigger major defects in the subsequent mitosis. We show that DNA2 helicase/nuclease, that regulates replication of centromeric DNA, is the key player responsible for severe chromosome pulverization in mitosis. The heightened vulnerability of aneuploid cells to WEE1 inhibition, coupled with underlying molecular mechanisms, provides a rationale for clinical exploration of WEE1-targeted therapies against aneuploid breast cancers.Impact StatementIncreased vulnerability of aneuploid cells to WEE1 inhibition is orchestrated by the DNA2 nuclease/helicase. These findings open new therapeutic strategies in the context of personalized medicine in breast cancer.
Mediating effect of ESG performance on executive incentive compensation-financial performance relationship: evidence from MENA banking sector
Authors: Ben Ali Abdelhakim , Chouaibi Jamel 
Published: September 2023

Purpose
This study aims to investigate whether integrating environmental, social and governance (ESG) practices mediates the relationship between executive incentive compensation and the financial performance of Islamic and conventional banks in the Middle East and North Africa (MENA) region.

Design/methodology/approach
This study used multiple regression models to analyze the effectiveness of ESG practices as a mediating variable in explaining the relationship between executive incentive compensation and banks’ financial performance between 2015 and 2021. The sample consisted of 57 Islamic and conventional banks operating in the MENA region, and the data were collected from the Thomson Reuters database (Data Stream).

Findings
This research paper showed the positive and significant mediating effect of the ESG practice on Banks’ financial performance. Thus, banks’ financial and stock market profitability is influenced by ESG information disclosure. This finding shows that taking ESG into account improves the relationship between executive incentive compensation and banks’ financial performance.

Practical implications
The results may interest academic researchers, regulators and policymakers and would support stakeholders and decision-makers who wish to discover how executive incentive compensation affects financial performance in banks.

Originality/value
This study contributes to previous literature by studying the mediating effect of ESG practices on the relationship between executive incentive compensation and banks’ financial performance. Indeed, the originality of this research paper is justified by the scarcity of studies and, to the best of the authors’ knowledge, constitutes one of the first attempts to examine this relationship via a mediating variable, i.e. ESG.
Culture and technology in digital transformations: how large companies could renew and change into ecosystem businesses
Authors: Steiber Annika , Alvarez Don 
Published: September 2023

PurposeThe purpose and theoretical contributions of this paper are to improve current knowledge on culture's role in firms' digital transformation, as well as to identify and add a cultural “digital maturity” lens to well-known, already actionable frameworks for the digital transformation of firms.Design/methodology/approachTo increase current knowledge on culture's role in firms' digital transformation, as well as to identify and add a cultural “digital maturity” lens to well-known and actionable frameworks for the digital transformation of firms, a multi-step approach was chosen, including both literature reviews as well as a qualitative study of one company case.FindingsEarly generations of digital transformation frameworks, mainly from the field of information systems (IS), did not take into consideration firms' culture. More recent research in the fields of management and organization, however, emphasizes the role of culture and key cultural attributes favorable for a digital transformation. By integrating key findings on digital transformation from these research fields, a multi-disciplinary framework could be presented, allowing any organization to plan, organize and monitor a digital transformation from three essential lenses: technical (processes and actions for transforming), social (transformation of norms and behavior) and macro (transformation of the perception of the outside world).Research limitations/implicationsOnly one case study was included in this study. The developed multi-disciplinary framework needs to be tested in more cases.Practical implicationsPractitioners can use the new integrated framework above for evaluating the conditions for, and the progression of a digital transformation, by using the developed framework and by applying the three lenses.Social implicationsOriginality/valueThe paper contributes a new multi-disciplinary integrated framework for the digital transformation of enterprises and a further understanding of the impact of culture in the transformation of the firm.
A comprehensive review of environmental, sustainability and climate change curriculum in Taiwan’s higher education institutions
Authors: Liu John Chung-En , Kan Ting-Yu 
Published: September 2023

Purpose
This study aims to evaluate the current situation of education for sustainable development, climate change education and environmental education in a nationwide context. Methodologically, this study calls for more research to go beyond case studies and take a similar approach to examine university curricula and facilitate cross-country comparisons.

Design/methodology/approach
This paper examines the status of climate and sustainability curricula in Taiwan’s higher education system. Using the course catalog for the 2020–2021 academic year, the authors constructed a unique data set that includes 1,827 courses at 29 major universities in Taiwan. In each institution, the authors search for course titles that include “climate,” “sustainable/sustainability” and “environment/environmental” as keywords and code the courses according to their disciplines.

Findings
The finding highlights the variations across institutional types and subject matters. Public universities have an average of 4.94 related courses per 1,000 students, whereas private universities have only 3.13. In general, the relevant courses are more concentrated in the STEM and bioscience fields. The curricula, however, are seriously constrained by the disciplinary structure and foster few transdisciplinary perspectives.

Originality/value
The authors seek to go beyond case studies and offer one of the most comprehensive curricula samples at the national level. Taiwan adds an important data point, as the current literature focuses heavily on the USA and Europe.
B2B supply chain risk measurement systems: a SCOR perspective
Authors: Guillot Romane , Dubey Rameshwar , Kumari Sushma 
Published: September 2023

Purpose
Globalisation, trade barriers, unprecedented health crises and geo-political crises have forced organisations to revisit their performance measurement systems (PMS) to better prepare their supply chain against the risk and improve performance in times of crisis. This study aims to review the supply chain operation reference (SCOR)-based PMS and propose a dynamic SCOR-based PMS for supply chain risk management (SCRM).

Design/methodology/approach
Due to the need for multi-stakeholder perspectives on SCOR-based PMS for the SCRM, the authors aimed to develop a theory rather than to elaborate upon or test the theory. Hence, the authors adopted an inductive theory-building approach to build research propositions. The authors also gathered 12 semi-structured interviews with knowledgeable managers from B2B international companies.

Findings
The findings of the study highlight the challenges faced by the organisations during the implementation of the SCOR-based performance indicators and the positive impacts they have on decision-making and on the continuous improvement strategy of organisations to tackle supply chain risks and improve performance. The findings suggest that the effects of these indicators are more felt during risk management and risk monitoring stages.

Research limitations/implications
Like any other study, this study has some rules, and, thus, the authors caution the readers that they must interpret the findings of the research considering these limitations. The study is based on semi-structured qualitative interviews. The interviews were conducted with 12 knowledgeable managers from France; thus, the insights drawn from the study cannot be generalised to other settings. Furthermore, the samples represent something other than small and medium enterprises. In the future, the samples from small and medium firms can offer a nuanced understanding of the performance indicators for SCRM.

Originality/value
To the best of the authors’ knowledge, this is one of the few studies which has attempted to revisit the SCOR-based PMS in the B2B supply chain for risk management. The study’s findings help expand the SCOR-based PMS literature and offer numerous insights to the management and consultants facing challenges in SCOR implementation.
CSR employer branding, organisational identification, person–organisation fit and employee retention: a dual mediation model
Authors: Bharadwaj Shubhangi 
Published: September 2023

PurposeCorporate social responsibility (CSR) is gaining recognition and value among researchers, academicians and business professionals. Drawing on theories of social identity and person–organisation fit, the present research propounds a model that investigates the role of CSR branding in influencing employee retention.Design/methodology/approachThe paper is based on primary survey data from 348 employees working in organisations in the Indian industrial hubs. The study uses the regression and PROCESS macro model to analyse relationship among study variables.FindingsThe study indicated how CSR initiatives could help organisations handle the threat of high turnover storm all over the world, thereby retaining the employees with a high set of skills. Moreover, the paper connotes that employee retention is influenced directly by CSR branding as well as indirectly under the presence of organisational identification and person–organisation fit (mediators).Practical implicationsResults suggest the role of a positive identity and a mutual fit as significant predictors of employee retention. The implications for future research on CSR, employees' stay intentions, employees' identification and value congruence are further discussed in light of the findings.Originality/valueThe novelty of this research insists on shedding light on the indirect mechanisms linking CSR to employee retention that has been overlooked so far, particularly in the Indian setting; studies on an integrated model of organisational identification and person–organisation fit are limited.
Leadership, trustworthiness and employee engagement: an insight during the COVID-19
Authors: Iddagoda Anuradha , Dissanayake Hiranya , Bagienska Anna 
Published: September 2023

PurposeThe purpose of this study is to explore the associations between leadership, trustworthiness, and employee engagement during COVID-19.Design/methodology/approachIn this cross-sectional, quantitative study, surveys of Sri Lankan male and female managers were conducted via standardized questionnaires. The sample size was 297 respondents. The Smart-PLS version 3.36 structural equation model analyzed the data set.FindingsBoth leadership and employee engagement and trustworthiness and employee engagement were found to have a statistically significant relationship. It has been found that leadership indirectly contributes to a higher degree of employee engagement through increased trustworthiness. According to the findings, employee engagement rises when they have the trustworthiness of the leadership in the virtual environment.Research limitations/implicationsAccording to the findings of this study, organizations need to introduce rules to improve leadership manager roles in a virtual environment, which can improve trustworthiness and employee engagement. It also suggests that organizations should build trustworthiness between employees and leadership through a positive culture in a virtual environment that can improve employee engagement and organizational performance.Originality/valueResearch on leadership and trustworthiness improves employee engagement in a virtual environment is the contribution of this study.
Motivating public health emergency preparedness cooperative behaviors: based on the expectancy disconfirmation model
Authors: Hong Yuxiang , Zhao Jiaqing , Zhang Yue , Su Qiang 
Published: September 2023

PurposeIn this study, the expectancy disconfirmation model (EDM) was applied to explain the formation of public health emergency preparedness cooperative behavior (EPCB) as well as considering the roles of official media exposure and positive emotions.Design/methodology/approachThe analysis was based on a sample of 374 respondents collected during the coronavirus (COVID-19) pandemic. A t-test was used to examine the differences in variables by sex, age and educational background. Hypothesis testing was conducted using structural equation modeling. Amos 24.0 and R 4.0.3 were used to analyze the data.FindingsThe results indicated that (1) official media exposure has a positive impact on expectations for and perceived performance of public services, as well as positive emotions; (2) the EDM can be used to explain public satisfaction with government public health services; and (3) public satisfaction and positive emotions have positive effects on EPCB; (4) EDM and positive emotions mediate the relationship between official media exposure and EPCB.Originality/valueThis study provides practical implications for increasing the EPCB from the perspective of risk communication.
Assessment and risk mitigation on halal meat supply chain using fuzzy best-worst method (BWM) and risk mitigation number (RMN)
Authors: Masudin Ilyas , Zuliana Putri Elma , Utama Dana Marsetiya , Restuputri Dian Palupi 
Published: September 2023

Purpose
The purpose of this study is to identify the risks that exist in halal meat supply chain activities and to carry out a risk assessment using the fuzzy best-worst method (FBWM) along with mitigating risks using the risk mitigation number (RMN).

Design/methodology/approach
The method used is to collect several literature reviews related to the halal meat supply chain, which has information relevant to the risks of the meat industry in Indonesia. Then, a focus group discussion was held with several experts who play a role in the meat industry in Indonesia, and 33 identified risks were identified in halal meat supply chain activities. The proposed methodology uses FBWM and RMN in conducting risk assessment and mitigation in the meat industry in Indonesia.

Findings
The analysis reveals that priority risk is obtained by using the global weight value on the FBWM, and then risk mitigation is carried out with RMN. Priority mitigation strategies can mitigate some of the risks to the meat industry in Indonesia. The proposed mitigation strategy is designed to be more effective and efficient in preventing risks that can interfere with product halalness in halal meat supply chain activities in the Indonesian meat industry.

Research limitations/implications
The implications of this study highlight the need for collaboration among stakeholders, improved risk assessment methodologies and the expansion of research into other halal supply chains. By addressing these implications, the halal industry can enhance its integrity, consumer confidence and overall contribution to the global market.

Originality/value
This research provides an integrated approach to identifying, analyzing, assessing and mitigating risks to the meat industry in Indonesia.
Digital service innovation (DSI): a multidisciplinary (re)view of its origins and progress using bibliometric and text mining methods
Authors: Rabetino Rodrigo , Kohtamäki Marko , Huikkola Tuomas 
Published: September 2023

PurposeThis paper studies the Digital Service Innovation (DSI) concept by systematically reviewing earlier studies from various scholarly communities. This study aims to recognize how recent advances in DSI literature from different research streams complement and can be incorporated into the growing digital servitization literature to define better and understand DSI.Design/methodology/approachAfter systematically identifying 123 relevant articles, this study employed complementary methods, such as author bibliographic coupling, linguistic text mining/textual analysis and qualitative content analyses.FindingsThis paper first maps the intellectual structure and boundaries of the DSI-related communities and qualitatively assesses their characteristics. These communities are (1) Innovation for digital servitization, (2) Service innovation in the digital age and (3) Adoption of novel e-services enabled by information system development. Next, the composition of the DSI concept is examined and depicted to comprehend the notion's critical dimensions. The findings discuss the range of theories and methods in the existing research, including antecedents, processes and outcomes of DSI.Originality/valueThis study reviews, extends the understanding of origins and critically evaluates DSI-related research. Moreover, the paper redefines and clarifies the structure and boundaries of the DSI-concept. In doing so, it elaborates on the substance of DSI and identifies the essential themes for its understanding and conceptualization. Thus, the study helps the future development of the concept and allows knowledge accumulation by bridging adjacent research communities. It helps researchers and managers navigate the foggy emerging research landscape.
Mediation-moderation model of green absorptive capacity and green entrepreneurship orientation for corporate environmental performance
Authors: Makhloufi Lahcene , Djermani Farouk , Meirun Tang 
Published: September 2023

PurposeDrawing upon the natural resource-based view (NRBV), green absorptive capacity (GAC) is the backbone of firm green dynamic capabilities. It converts the developed knowledge into knowledge application. Understanding how GAC could benefit corporation environmental performance (EP) is still ambiguous and debated. Hence, this study introduced three facilitator factors, namely, managerial environmental concern (MEC), green innovation performance (GIP) and green entrepreneurship orientation (GEO), in which GAC can improve EP. The study tested the moderation effect of GAC and GEO on the MEC-GEO and the MEC-EP relationships and predicted the mediation effect of MEC, GEO and GIP on the GAC-EP relationship.Design/methodology/approachThe quantitative study used a self-administered survey and cross-sectional research design; the study collected data from top management employees working in Chinese manufacturing firms.FindingsThe results indicated that GAC positively influences MEC, GEO and GIP, and these last three constructs influence EP. While MEC positively affects GIP, the MEC-GEO relationship was insignificant. The study found that GAC moderates the MEC-GEO relationship, whereas GEO failed to do so between MEC and EP. The results confirm a partial mediation effect between GAC-EP through the three intermediary constructs.Practical implicationsTo promote EP, firms GAC should prioritize developing MEC ad GIP. Firms' GEO can exploit eco-friendly opportunities enabled by GAC, a process that bridges the existing knowledge and skills gap between MEC and GEO. GAC is one of the leading green strategic capabilities that help GEO to achieve green business growth and better EP. MEC is the process of facilitating GIP to deliver eco-products and protect the external environment. When MEC failed to address GEO's green business agenda, GEO could not enhance EP.Originality/valueThe study highlights the necessity of GAC to develop firms' green dynamic capabilities to boost EP. The study confirms GAC's vital role in strengthening the manager's environmental awareness and bridging the knowledge gap between GEO and MEC. In addition, GIP can drive entrepreneurial green opportunities and enhance EP when GAC is involved and converts knowledge creation to knowledge applications. Strategically speaking, given the importance of the triple green pillars of the NRBV, GEO would not balance green business growth and EP unless GAC leveled up MEC to match GEO's green business agenda and drive EP.
Fear of terrorist attacks and psychological distress in Sub-Saharan Africa: moderated mediation model
Authors: Hevi Stewart Selase , Agbenorxevi Clemence Dupey , Malcalm Ebenezer , Gborse Nicholas Mawunyah Mawunyah , Hevi Jeffrey Mawutor , Preko Vincent Yaw 
Published: September 2023

Purpose
This paper aims to investigate the moderated-mediation roles of perception of police response to crime and digital interclass coalition against crime between fear of terrorist attacks and psychological distress among residents of Tema Metropolis in Ghana.

Design/methodology/approach
A cluster sampling technique was used in the selection of 577 residents who answered questions on fear of terrorism, perception of police response to crime, digital interclass coalition against crime and psychological distress. The study used regression analysis to assess the hypothesized paths.

Findings
The findings show that digital interclass coalition against crime moderates the partially mediated relationship between perception of police response to crime and residents’ psychological distress.

Research limitations/implications
The study is limited in scope by the generalization of its findings, as it was restricted to only residents of Tema Metropolis in the Greater Accra Region of Ghana.

Originality/value
This research is one of the first in criminal psychology to explore the relevance of police-public engagement in averting large-scale crime in an emerging economy.