bluuebunny/crossref_metadata_2025_split huggingface dataset:
Presence of infratrappean Gondwana sediments below Deccan volcanic covered 1993 Killari earthquake region, Maharashtra (India) and geodynamical instability of the south Indian craton
Authors: Pandey Om Prakash , Sharma Mukund , Shukla Bandana , Kumar Madhav , Ram‐Awatar  , Parthasarathy Gopalakrishnarao , Sesha Sai Valiveti Venkata , Sreedhar Bojja , Tripathi Priyanka , Dayal Anurodh Mohan , Chandrakala Koteswara 
Published: March 2023

KLR‐1 scientific deep borehole, drilled in the 1993 Killari earthquake region of Maharashtra (India), penetrated 8 m thick infratrappean sediments below a 338 m‐thick column of Deccan volcanics that rested over Neoarchean amphibolite to granulite facies mid‐crustal basement. Detailed palynological studies revealed the presence of characteristic Gondwana palynomorphs in sedimentary succession that include Plicatipollenites indicus, P. trigonalis, Parasaccites korbaensis, P. diffusus, Microbaculispora indica, Cyclobaculisporites minimus, Cyclogranisporites barakarensis, C. gondwanensis, Jayantisporites pseudozonatus, Leiosphaeridia bokaroensis, Latosporites sp., Verrucosisporites sp., cf. V. ambiplicatus and Striatopodocarpites gondwanensis. Qualitative analyses of palynomorphs would suggest an Asselian age (298–295 Ma) for their formation and burial in dysoxic to anoxic conditions. Recorded palynological assemblages correlate well with continental Lower Gondwana (Early Permian) sediments of India, as well as other Gondwana continents, indicating a larger extent of Gondwana sedimentation than hitherto known today. Petrological studies indicate the presence of two types of carbonate units that overly the crystalline basement. A relatively coarse‐grained sparry carbonate rock immediately overlies the basement (Sample KIL‐7). The size of the carbonate crystals in the sparite vary from 100 to 500 μm. This unit is overlain by an extremely fine‐grained micrite resembling lime mud (Sample KIL‐6). Micrite is made of carbonate grains with an average size of 10 μm. X‐ray diffraction studies indicate that calcite is the dominant carbonate mineral, while dolomite and quartz occur in minor amounts. Geochemical analyses indicate that in these two samples of carbonate rock that overlie the basement, CaO (33.38 to 38.16 wt %) is higher than MgO (16.0–23.85 wt%). These infratrappeans sediments are also characterized by stable carbon (δ13C) and oxygen (δ18O) isotopic ratios ranging from −1.59 to −8.74‰ and −9.12 to −13.50‰ versus PDB, respectively, thereby conforming to non‐marine fresh water deposits. These findings provide first evidences of reactivation and rifting of Dharwar intracratonic regions during earliest Permian Gondwana Period, which led to severe lithospheric mantle destruction, and massive regional uplift and erosion of the granitic‐gneissic upper crust. Large scale inland‐rifting during the Gondwana sedimentation period was possibly a prelude to India‐Antarctic breakup during the early Cretaceous.
Evaluation of boundaries between mood and psychosis disorder using dynamic functional network connectivity (dFNC) via deep learning classification
Authors: Rokham Hooman , Falakshahi Haleh , Fu Zening , Pearlson Godfrey , Calhoun Vince D. 
Published: March 2023

AbstractThe validity and reliability of diagnoses in psychiatry is a challenging topic in mental health. The current mental health categorization is based primarily on symptoms and clinical course and is not biologically validated. Among multiple ongoing efforts, neurological observations alongside clinical evaluations are considered to be potential solutions to address diagnostic problems. The Bipolar‐Schizophrenia Network on Intermediate Phenotypes (B‐SNIP) has published multiple papers attempting to reclassify psychotic illnesses based on biological rather than symptomatic measures. However, the effort to investigate the relationship between this new categorization approach and other neuroimaging techniques, including resting‐state fMRI data, is still limited. This study focused on investigating the relationship between different psychotic disorders categorization methods and resting‐state fMRI‐based measures called dynamic functional network connectivity (dFNC) using state‐of‐the‐art artificial intelligence (AI) approaches. We applied our method to 613 subjects, including individuals with psychosis and healthy controls, which were classified using both the Diagnostic and Statistical Manual of Mental Disorders (DSM‐IV) and the B‐SNIP biomarker‐based (Biotype) approach. Statistical group differences and cross‐validated classifiers were performed within each framework to assess how different categories. Results highlight interesting differences in occupancy in both DSM‐IV and Biotype categorizations compared to healthy individuals, which are distributed across specific transient connectivity states. Biotypes tended to show less distinctiveness in occupancy level and included fewer cellwise differences. Classification accuracy obtained by DSM‐IV and Biotype categories were both well above chance. Results provided new insights and highlighted the benefits of both DSM‐IV and biology‐based categories while also emphasizing the importance of future work in this direction, including employing further data types.
Structure–property relationship of dipyridyl−Cu polymers containing inorganic clusters Te/SeFe3(CO)9
Authors: Shieh Minghuey , Li Yu‐Huei , Hsu Ming‐Chi 
Published: March 2023

AbstractThis mini‐review covers a novel series of 1D and 2D Te/SeFe3(CO)9‐incorporated (Te, 1a; Se, 1b) Cu‐based coordination polymers synthesized by the liquid‐assisted grinding (LAG) method using predesigned compound [TeFe3(CO)9Cu2(MeCN)2] (1a‐Cu2(MeCN)2) with rigid or flexible dipyridyl ligands, or three components of [SeFe3(CO)9]2− (1b), [Cu(MeCN)4]+, and dipyridyls. These polymers displayed various cluster coordination modes, including cluster‐blocked [EFe3(CO)9Cu2(L)]n (E = Te, 1a‐L‐1D, Se, 1b‐L‐1D; L = 1,2‐bis(4‐pyridyl)ethylene (bpee), 1,2‐bis(4‐pyridyl)ethane (bpea)), cluster‐pendant [SeFe3(CO)9Cu2(dpy)3]n (1b‐dpy‐1D, dpy = 4,4′‐dipyridyl) and [EFe3(CO)9Cu2(L)2.5]n (E = Te, 1a‐L‐2D, Se, 1b‐L‐2D; L = bpee, bpea), cluster‐linked [SeFe3(CO)9Cu2(MeCN)(dpy)1.5]n (1b‐dpy‐2D) and [SeFe3(CO)9Cu2(bpp)2]n (1b‐bpp‐2D, bpp = 1,3‐bis(4‐pyridyl)propane), as well as the unique cation‐anion polymer [{Cu2(bpp)4}{(TeFe3(CO)9Cu)2(bpp)}]n (1a‐bpp‐CA). Their dimensionality expansions and reversible transformations accompanied with bonding pattern changes were achieved upon the addition of stoichiometric amounts of appropriate agents. These polymers exhibited pronounced semiconducting properties with tunable energy gaps and optical (dc) or electrical conductivities. The trend of their semiconductivities can be related to bonding patterns, where efficient electron communications were proved to stem from the existence of carbonyl ligands and electron‐rich clusters 1a and 1b. In particular, water−/light‐stable 1b‐based polymers exhibited excellent photodegradation activities toward nitroaromatics and organic dyes, where the efficiency was further rationalized by their structural features and narrow energy gaps.
House sparrows prioritize skin repair over constitutive innate immunity during long‐term chronic stress
Authors: Beattie Ursula K. , Rosen Emma S. , Fefferman Nina , Romero L. Michael 
Published: March 2023

AbstractThe reactive scope model was created to address two major unanswered questions in stress physiology: how and when does the adaptive acute stress response turn into harmful chronic stress? Previous studies suggest that immunoenhancement should occur in reactive homeostasis (acute stress) and immunosuppression should occur in homeostatic overload (chronic stress). We used this dichotomy of immune function to further elucidate the transition from acute to chronic stress by treating house sparrows (Passer domesticus) with different intensities of chronic stress and then monitoring their immune function. By varying the number of stressors given per day and the length of chronic stress bouts over a period of 6 months, we produced four treatment groups: high, medium, and low stress, and captivity‐only. We tracked immunity through the bacterial killing assay and monitored healing of a 4 mm skin biopsy punch. We hypothesized that higher‐stress birds would repair their skin more slowly and have lower bacterial killing capacity. The opposite was true—high‐stress birds initially repaired their skin fastest. Additionally, all birds dramatically reduced bacterial killing capacity after the biopsy and increased food‐derived uric acid, suggesting increased energy acquisition and a shift in immune resources to a more immediate concern (healing). Once healing finished, only the high‐stress birds were unable to recover circulating immune function, suggesting that the combination of high stress and an immune challenge pushed these birds into homeostatic overload. Prioritizing healing over other immunological processes might be the best defense for a bird in its natural habitat.
The current fertilizer regimes cause phosphorus deficit in paddy soils and decreased rice phosphorus uptake: a study in Shanghai, China
Authors: Chu Qingnan , Xu Shuhan , Xing Yue , Cao Linkui , Yang Xiaolei , Sha Zhimin 
Published: March 2023

AbstractExcessive phosphorus (P) fertilization in intensive rice‐cultivation areas in China has caused serious environmental problems. However, relatively little research has been done on investigating the soil P balance in rice production systems based on different fertilizer regimes. Our study investigated the dynamic variation of soil P balance and rice P use efficiency and productivity from 2014 to 2018 in the paddy fields under synthetic fertilizer (CF) and manure application (OF) regimes based on the practices of local farmers. Flooding water on the paddy fields tends to cause P loss via runoff and leaching. A lysimeter system was used to monitor P loss from paddy fields, which overcame the limitations of real‐time monitoring discharge volume and sample‐collection. The results with relatively higher rainfall intensity in 2014 and 2015, in total, 4.69 kg P ha−1 under CF and 8.39 kg P ha−1 under OF were lost via runoff in 2014, with 13.6 kg P ha−1 under CF and 17.8 kg P ha−1 under OF in 2015, whereas from 2015 to 2018, no more than 5 kg P ha−1 was lost in CF or OF via runoff. Leaching showed a similar, varying trend for both CF and OF. Furthermore, during the 5 years, a continuous soil P deficit was observed, except in 2017 and 2018 for CF and 2018 for OF. The net P retention ranged from −15.31 to 6.2 kg ha−1 for CF and from −23.65 to 2.64 kg ha−1 for OF. The continuous P deficit in paddy soils might have reduced soil P storage. These huge P losses undermined rice yield production. In parallel, after 2014, the grain yield decreased from 10,885.7 in 2014 to 6266.7 kg ha−1 in 2017 under CF and from 10,607.6 to 6649.6 kg ha−1 under OF. Overall, these results reveal a risk of declining P storage in paddy soils and a potential menace on food safety under the current fertilizer management, suggesting that novel fertilizer strategies need to be developed for reserving P storage in paddy fields.
Electronic‐Resonance‐Enhanced Coherent Raman Spectroscopy with a Single Femtosecond Laser Beam
Authors: Zhang Ning , Xie Hongqiang , Zhang He , Lu Xu , Chen Yewei , Wu Yuzhu , Cheng Ya , Yao Jinping 
Published: March 2023

AbstractCoherent Raman scattering (CRS) spectroscopy holds versatile applications in many fields ranging from measuring temperature and concentration in reacting flows to imaging biological molecules in living cells. Although the powerful spectroscopic technique has been studied for a few decades, significant attention is still paid to developing state‐of‐the‐art CRS spectroscopy with the simpler design and higher sensitivity for practical applications in harsh or complex environments. Herein, a novel electronic‐resonance‐enhanced coherent Raman scattering (ERE‐CRS) technique is developed with a single femtosecond laser beam. Such single‐beam ERE‐CRS scheme is accomplished with the narrowband air lasing signal naturally generated in the interaction region as a probe source. The developed technique not only avoids fine spatio‐temporal control in the conventional multibeam configuration, but also accomplishes 1–2 orders of magnitude enhancement of Raman signal due to the resonance of air lasing with electronic transition of the target gas. The dramatic enhancement effect is also manifested through the comparative measurements in CO2 isotopes. The single‐beam ERE‐CRS spectroscopy shows an unprecedented opportunity for the high‐sensitivity standoff detections of gas‐phase molecules and plasmas.
Circ_0007429/miR‐637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC
Authors: Fan Lilan , Xia Panpan , Wang Jing , Xu Shun , Qiu Zijian , Wu Yan , Feng Maohui , Zhao Qiu , Wang Hongling , Li Xuanfei 
Published: March 2023

AbstractCircRNAs play an important role in the progression of hepatocellular carcinoma (HCC), however, the role of circ_0007429 in HCC remains unknown. Using bioinformatics tools, we selected circ_0007429 that was most highly expressed in HCC tissues and investigated its role in HCC progression. Immunohistochemistry, plasmid transfection, real‐time quantitative PCR, and western blot analysis were used to identify the relationship between circ_0007429 and its potential target, miR‐637, and TRIM71. The regulatory effect of circ_0007429 on miR‐637/TRIM71/Ago2 signaling and its key role in HCC progression were studied in vitro. A nude mouse xenograft model was used to examine tumor growth in vivo. Circ_0007429 and TRIM71 expression were upregulated, while miR‐637 expression was downregulated in HCC tissues and cells compared with their expression in control groups. Knockdown of circ_0007429 enhanced apoptosis in HCC cells, while impeded proliferation, migration, invasion, and aerobic glycolysis, which were reversed by miR‐637 inhibitor. High levels of circ_0007429 correlated with a poor survival rate of HCC patients. Additionally, circ_0007429 interfering inhibited tumor growth in vivo. TRIM71 directly bound to miR‐637 and inhibited Ago2 expression. Moreover, circ_0007429 promotes aerobic glycolysis in HCC cells through the miR/TRIM71/Ago2 axis. Circ_0007429 promotes HCC progression by promoting cell proliferation, migration, invasion, and aerobic glycolysis and by inhibiting cell apoptosis through the miR/TRIM71/Ago2 axis. These results provide molecular insights into the mechanism of HCC and suggest that circ_0007429 could be a therapeutic target for HCC.
AKR1C3 suppresses ferroptosis in hepatocellular carcinoma through regulation of YAP/SLC7A11 signaling pathway
Authors: Chen Jinsi , Zhang Jia , Tian Wei , Ge Chao , Su Yuting , Li Jinjun , Tian Hua 
Published: March 2023

AbstractAKR1C3 is frequently overexpressed and it is a validated therapeutic target in various tumors including hepatocellular carcinoma (HCC). Our previous study showed that AKR1C3 facilitated HCC proliferation and metastasis by forming a positive feedback loop of AKR1C3‐NF‐κB‐STAT3. Ferroptosis is a form of iron‐dependent cell death driven by iron‐dependent accumulation of lipid reactive oxygen species and plays an important role in tumor suppression. However, little is known about the role of AKR1C3 in ferroptosis susceptibility. In this study, we found that knockdown of AKR1C3 potently enhanced the sensitivity of HCC cells to ferroptosis inducers both in vitro and in vivo. Overexpression of AKR1C3 protected against ferroptosis in HCC cells. Mechanistically, AKR1C3 regulated ferroptosis through YAP/SLC7A11 signaling in HCC. AKR1C3 knockdown led to a decrease in YAP nuclear translocation, resulted in the inhibition of cystine transporter SLC7A11, and a subsequent increase in the intracellular levels of ferrous iron and ultimately ferroptosis. Moreover, we found that the combination of AKR1C3 and SLC7A11 was a strong predictor of poor prognosis in HCC. Collectively, these findings identify a novel role of AKR1C3 in ferroptosis, and highlighting a candidate therapeutic target to potentially improve the effect of ferroptosis‐based antitumor therapy.
A novel tool for predicting the dose distribution of non‐sealed 188Re (Rhenium) resin in non‐melanoma skin cancers (NMSC) patients
Authors: Zagni Federico , Vichi Sara , Paolani Giulia , Santoro Miriam , Della Gala Giuseppe , Strolin Silvia , Castellucci Paolo , Vetrone Luigia , Fanti Stefano , Morganti Alessio Giuseppe , Strigari Lidia 
Published: March 2023

AbstractBackgroundHigh‐dose rate brachytherapy using a non‐sealed 188Rhenium resin (188Re) is a recently approved treatment option for non‐melanoma skin cancer (NMSC). The treatment goal is to deliver a personalized absorbed dose to the deepest point of neoplastic infiltration corresponding to the minimal target dose. The treatment consists of the application of a 188Re‐based resin over a plastic foil placed on the target skin surface. However, there is no treatment planning tool to assess the 188Re activity needed for a personalized treatment.PurposeThe paper aims to present a novel Monte Carlo (MC)‐based tool for 188Re‐based resin activity and dose calculation, experimentally validated using Gafchromic EBT3 films.MethodsMC simulations were carried out using FLUKA modeling density and composition of 188Re resin. The MC‐based look up table (LUT) was incorporated in an ad hoc developed tool. The proposed tool allows the personalized calculation of treatment parameters (i.e., activity to be dispensed, the treatment duration, and dose volume histograms), according to the target dimension. The proposed tool was compared using Bland–Altman analysis to the previous calculation approaches conducted using VARSKIN in a retrospective cohort of 76 patients. The tool was validated in ad hoc experimental set ups using a stack of calibrated Gafchromic EBT3 films covered by a plastic film and exposed using a homogenous activity distribution of 188Re eluate and a heterogeneous activity distribution of 188Re resin mimic the patient treatment.ResultsThe agreement between the proposed tool and VARSKIN was evaluated on the investigated cohort with median range of target area, target depth, and treatment time equal to 4.8 [1.0–60.1] cm2, 1.1 [0.2–3.0] mm, and 70 [21–285] min, with a median range of target dose (Gy) of 23.5 [10–54.9]. The calculated minimal target doses, ranged from 1% to 10% for intermediate target depths (1.2 ± 0.7 mm), while showing significant differences in the estimation of superficial (maximal) target doses. The agreement between MC calculation and measurements at different plans in a stack of Gafchromic EBT3 films was within 10% for both the homogenous and heterogeneous activity distribution of 188Re. Worst agreements were observed for absorbed doses lower than 0.3 Gy.ConclusionsOur results support the implementation of our MC‐based tool in the practical routine for calculating the 188Re resin activity and treatment parameters necessary for obtaining the prescribed minimal target dose.
Convergence analysis of a block preconditioned steepest descent eigensolver with implicit deflation
Authors: Zhou Ming , Bai Zhaojun , Cai Yunfeng , Neymeyr Klaus 
Published: March 2023

AbstractGradient‐type iterative methods for solving Hermitian eigenvalue problems can be accelerated by using preconditioning and deflation techniques. A preconditioned steepest descent iteration with implicit deflation (PSD‐id) is one of such methods. The convergence behavior of the PSD‐id is recently investigated based on the pioneering work of Samokish on the preconditioned steepest descent method (PSD). The resulting non‐asymptotic estimates indicate a superlinear convergence of the PSD‐id under strong assumptions on the initial guess. The present paper utilizes an alternative convergence analysis of the PSD by Neymeyr under much weaker assumptions. We embed Neymeyr's approach into the analysis of the PSD‐id using a restricted formulation of the PSD‐id. More importantly, we extend the new convergence analysis of the PSD‐id to a practically preferred block version of the PSD‐id, or BPSD‐id, and show the cluster robustness of the BPSD‐id. Numerical examples are provided to validate the theoretical estimates.
Observed‐over‐Expected analysis as additional method for pharmacovigilance signal detection in large‐scaled spontaneous adverse event reporting
Authors: van der Boom Meiwen D. X. , van Eekeren Rike , van Hunsel Florence P. A. M. 
Published: March 2023

AbstractBackgroundThe large‐scale COVID‐19 vaccination campaigns in 2021 and 2022 led to a rapid increase in numbers of received adverse event reports in spontaneous reporting systems. As background incidences of naturally occurring medical events became increasingly relevant for causality assessment of potential associations with the vaccines, a novel approach for signal detection was warranted.ObjectivesThis article illustrates the Observed‐over‐Expected (O/E) analysis as an additional method for signal detection and risk assessment in large‐scaled spontaneous reporting systems.MethodsAll individual case safety reports (ICSRs) concerning idiopathic peripheral facial paralysis or Bell's palsy following administration of the COVID‐19 vaccines (n = 291) manufactured by Pfizer/BioNTech (Comirnaty), Moderna (Spikevax), AstraZeneca (Vaxzevria) and Janssen (JCOVDEN) received by the National Pharmacovigilance Centre Lareb until 24th March 2022 were included in the O/E analysis, within a risk window of 7 and 14 days following immunisation. Dutch background incidence rates from 2019 and exposure of the Dutch population to the vaccines were obtained from the PHARMO institute and RIVM. The data was stratified in age groups, gender and administered dose in order to differentiate between population subgroups.ResultsBell's palsy was reported more frequently than expected in several population subgroups following administration of all four COVID‐19 vaccines, including children and adolescents. Among children, a high O/E ratio was found for boys aged 5–14 years after receiving the Pfizer/BioNTech vaccine. Regarding adolescents and young adults, women aged 15–24 years receiving Pfizer/BioNTech and Moderna, and men aged 15–24 years receiving Janssen developed Bell's palsy more often than expected. Furthermore, O/E ratios were high for individuals aged 25–64, regarding females receiving Pfizer, Moderna and AstraZeneca and males receiving Janssen. As facial paralysis was not labelled as an adverse event for the Janssen vaccine, this analysis contributed to signalling the association and warranting further regulatory action.ConclusionsThe O/E method is a useful approach for signal detection of potential adverse reactions when handling large numbers of ICSRs. Further research is needed to attest to the causality on a clinical basis.