bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of a structured non-pharmacological treatment of type 2 diabetes on glycated hemoglobin and body weight: a randomized controlled trial
Authors: Li V. V. , Dalenov Ye. D. , Dzeranova L. K. , Kim S. V. , Bazarova A. V. , Tarjibayeva S. K. , Slivkina N. V. , Kim I. S. 
Published: January 2023

BACKGROUND: Non-pharmacological treatments are an integral part of the treatment of all patients with type 2 diabetes (T2D). However, due to many factors, doctors and patients themselves tend to underestimate or completely neglect such effective methods in managing the course of the disease. Despite the high level of evidence of the effectiveness of this type of treatment for T2D, every year scientists around the world continue to actively study the effect of various non-drug methods on the course of the disease.AIM: To study the effect of a 24-week structured non-pharmacological treatment program on glycated hemoglobin reduction and weight loss in middle-aged patients with compensated T2D taking metformin.MATERIALS AND METHODS: A two-group, randomized, parallel-group, blinded trial was designed. Patients with an established diagnosis of T2D in the stage of compensation (HbA1c ≤7%), aged 45–59 years, taking metformin, were randomized to receive either standard non-pharmacological treatment of diabetes according to clinical protocol of T2D treatment in Kazakhstan, or an intensive course of non-pharmacological treatment according to a structured program developed by researchers. The duration of the intervention was 24 weeks. Primary outcomes were glycated hemoglobin, body weight. Secondary outcomes: blood pressure, waist circumference, insulin resistance index (HOMA-IR), lipid profile: total cholesterol, high and low density lipoproteins, triglycerides. The outcomes of the participants in both groups were assessed at baseline, 12 and 24 weeks after randomization. The study is registered with ClinicalTrials.gov NCT04632823.RESULTS: The study included 200 patients, 67 patients completed the study: intervention group n=33, control group n=34. After 24 weeks of observation, patients in the intervention group showed a significant decrease in HbA1c from 6.34% to 6.22%, p<0.001, while for the control group the level of HbA1c remained the same at 6.5% (p=0.703). Patients in both groups significantly reduced body weight, however, the decrease in the intervention group was more significant: by 6.7% of the initial level, while in the control group, only 1.1%. LDL, triglycerides, cholesterol level, HOMA-IR 2, and diastolic blood pressure did not decline significantly in the control group. All biochemical characteristics except triglycerides and LDL decreased significantly in the intervention group.CONCLUSION: The use of a structured program of non-pharmacological treatment of type 2 diabetes mellitus among compensated (HbA1c ≤7%) middle-aged patients who took metformin significantly reduced body weight and glycated hemoglobin in 24 weeks.
Insulin resistance and heart failure with preserved ejection fraction. Pathogenetic and therapeutic crossroads
Authors: Tsygankova O. V. , Evdokimova N. E. , Veretyuk V. V. , Latyntseva L. D. , Ametov A. S. 
Published: January 2023

Insulin resistance, which is a fundamental pathogenetic factor of prediabetes, is closely associated with abdominal obesity on the one hand and the development of cardiovascular diseases, heart failure (HF), on the other. The pathogenetic role of insulin resistance is multifaceted and consists in the acceleration of atherosclerosis, the formation of left ventricular myocardial hypertrophy, including through mechanisms that do not depend on blood pressure, as well as the development of its diastolic dysfunction. The latter is the starting point for starting HF with preserved ejection fraction (HFpEF).Compared with patients with HF with reduced ejection fraction, the presence of HFpEF determines a higher frequency of hospitalizations not due to decompensation of heart failure, but due to concomitant diseases, such as destabilization of the course of arterial hypertension, decompensation of type 2 diabetes mellitus, curation of which, in general, has a greater impact in terms of improving prognosis. Thus, in patients with prediabetes and HFpEF, the correction of insulin resistance as the underlying cause and trigger of cardiometabolic disorders can potentially improve not only insulin-glucose homeostasis, but also the parameters of myocardial diastolic function. This literature review is devoted to the accumulated experience of using metformin as a «strategic» antidiabetic drug in HFpEF and considering potential new points of its application as a protector of the cardiovascular system.
Diabetes mellitus — metabolic preconditioning in protecting the heart from ischemic damage?
Authors: Kondratieva D. S. , Afanasiev S. A. , Muslimova E. F. 
Published: January 2023

The negative impact of diabetes mellitus (DM) on the cardiovascular system has been confirmed by numerous clinical studies. However, there are experimental studies that show an increase in the resistance of the heart to ischemic and reperfusion damage in animals with DM. This phenomenon is characterized by a smaller size of the infarct zone, better preservation of the contractile function of the myocardium, and a lower incidence of ischemic and reperfusion arrhythmias. It is assumed that at a certain stage in the development of DM, a “metabolic window” is formed, in which metabolic alterations at the cellular level trigger adaptive mechanisms that increase the viability of cardiomyocytes. Published data confirm that the magnitude of the protective effect induced by DM is comparable to, and in some cases even exceeds, the effect of the preconditioning phenomenon. It is recognized that the mechanisms that protect the heart from ischemic and reperfusion damage against the background of DM are universal and are associated with the modulation of the antioxidant system, apoptosis factors, pro-inflammatory cytokines, and signaling systems that ensure cell survival. The one of the main pathogenic factor in DM is hyperglycemia, but under stress it plays the role of an adaptive mechanism aimed at meeting the increased energy demand in pathological conditions. Probably, at a certain stage of DM, hyperglycemia becomes a trigger for the development of protective effects and activates not only signaling pathways, but also the restructuring of energy metabolism, which makes it possible to maintain ATP production at a sufficient level to maintain the vital activity of heart cells under ischemia/reperfusion conditions. It is possible that an increased level of glucose, accompanied by the activation of insulin-independent mechanisms of its entry into cells, as well as the availability of this energy substrate, will contribute to a better restoration of energy production in heart cells after a infarction, which, in turn, will significantly reduce the degree of myocardial damage and will help preserve the contractile function of the heart. Identification of the conditions and mechanisms of the cardioprotective phenomenon induced by DM will make it possible to simulate the metabolic state in which the protection of cardiomyocytes from damaging factors is realized.
Predictors of success and failure in achieving glycemic control targets in patients with type 2 diabetes on basal insulin: review of the real-world evidence studies
Authors: Klimontov V. V. 
Published: January 2023

Basal insulin (BI) is the main therapeutic option for patients with type 2 diabetes (T2D) who have not reached glycemic targets on oral antidiabetic drugs and/or glucagon-like peptide-1 receptor agonists. The results of epidemiological studies indicate that the majority of patients with T2D do not achieve the targeted parameters of glycemic control on BI in the real-world settings. In this review the results of real-world evidence studies assessing predictors of success or failure of BI therapy in patients with T2D are we summarized. A number of studies have demonstrated that delayed initiation of insulin therapy with a high level of glycated hemoglobin A1c (HbA1c) at the start of the treatment reduces achieving glycemic control targets on BI. Hypoglycemia in the first weeks or months of BI treatment may reduce the adherence and persistence to treatment and likelihood of achieving treatment targets. In real-world evidence studies, glargine 300 U/mL and degludec, the long-acting second-generation insulin analogues, have shown greater potential in reduction of HbA1c levels with a lower risk of hypoglycaemia compared to other BIs. In the DUNE, ATOS, and some others studies, a lack of insulin dose titration in newly initiated BI users and those who needed treatment intensification was demonstrated. Poor treatment adherence and persistence (missed injections, incorrect dose selection, and temporary or permanent discontinuation of insulin therapy), deviations in insulin injection technique, and formation of lipohypertrophy at the injection sites are also common problems that prevent good glycemic control in these patients. Therefore, patient education with a focus on injection technique, dose titration and prevention of hypoglycemia, as well as the use of the second-generation BI analogs, increases the chances for achieving glycemic control targets in patients with T2D who initiate or need to intensify BI therapy.
The Role of Professional Quality of Life in Physical and Psychological Health of Textile Employees
Authors: Rasheed Ayesha 
Published: January 2023

The quality of life in employees is an issue that must be examined as it is a crucial point for organization or industry growth. This study aims to investigate the correlation between professional quality of life with physical and psychological health in textile sector employees. Study was conducted on (N=150, male and female employees) employees from 19 textile companies in Lahore city, Pakistan. A correlational research design was used, and sample was selected by using stratified sampling technique. A series of questionnaire (Professional Quality of life and (SF-12) Short Form-12 Health survey) was administered to employees after taking consent from the them. The results indicate that quality of life has relationship with physical and psychological health. Specifically, compassion satisfaction aspect has positive significant relationship with physical and mental health component while inverse relationship with burnout and compassion fatigue. When compassion satisfaction increases, the physical and psychological health of the workers improved and vice versa. Similarly, when burnout and compassion fatigue increase, it affected the physical and psychological health of the workers. It is recommended to the organization to make plans and policies to boost up employees mental and physical health. Kualitas hidup karyawan merupakan masalah yang harus diperhatikan terutama dalam dunia kerja. Penelitian ini bertujuan untuk mengetahui hubungan antara kualitas hidup professional dengan kesehatan fisik dan psikologis pada karyawan sektor tekstil. Studi dilakukan pada (N=150, karyawan pria dan wanita) karyawan dari 19 perusahaan tekstil di kota Lahore, Pakistan. Rancangan penelitian yang digunakan adalah korelasional, dan sampel dipilih dengan menggunakan teknik stratified sampling. Serangkaian kuesioner (Professional Quality of life dan (SF-12) Short Form-12 Health survey) diberikan kepada karyawan setelah mendapat persetujuan dari mereka. Hasil penelitian menunjukkan bahwa kualitas hidup memiliki hubungan dengan kesehatan fisik dan psikologis. Secara khusus, aspek compassion satisfaction memiliki hubungan positif yang signifikan dengan komponen kesehatan fisik dan mental, sedangkan hubungan terbalik dengan burnout dan compassion fatigue. Ketika compassion satisfacion meningkat, kesehatan fisik dan psikologis pekerja meningkat dan sebaliknya. Demikian pula ketika burnout dan compasison fatigue meningkat, hal itu mempengaruhi kesehatan fisik dan psikologis para pekerja. Disarankan kepada organisasi untuk membuat rencana dan kebijakan untuk meningkatkan kesehatan mental dan fisik karyawan.
The moderating effect of coping behavior on academic stress and subjective well-being in students during the Covid-19 pandemic
Authors: Quarta Dicky Listin , Nugraha Sumedi P 
Published: January 2023

This study aimed to observe the correlation between academic stress and subjective well-being, with coping behavior as a moderator in students during the COVID-19 pandemic. This involved 212 students in the UII. This study used the Perceived Stress Scale (18 items, a = 0.757), stress coping scale (44 items, a = 0.880), and college student subjective well-being questionnaire (16 items, a = 0.893). This study showed a significant negative correlation between academic stress and subjective well-being (β = -0.562; p < 0.05). Furthermore, the moderator regression analysis (MRA) results showed that the R² value of the interaction between academic stress and coping behavior as the moderator in the third regression model was higher than that of the other models (0.213). However, the increase was not statistically significant. The results showed that coping behavior did not have a moderating effect on the relationship between academic stress and subjective well-being. Penelitian ini bertujuan untuk mengeksplorasi peran perilaku coping sebagai noderator hubungan antara stres akademik dan kesejahteraan subjektif pada mahasiswa selama pandemi COVID-19. Sebanyak 212 orang mahasiswa Universitas Islam Indonesia telah terlibat dalam penelitian ini. Perceived stress scale (18 item, a = 0.757), skala coping stress (44 aitem, a = 0.880), dan college student subjective well-being questionnaire (16 item, a = 0.893) merupakan alat ukur dalam penelitian ini. Penelitian ini menemukan hubungan antara stres akademik dan kesejahteraan subjektif yang negatif dan signifikan (β = -0.562; p < 0.05). Selanjutnya, hasil moderator regression analysis (MRA) menunjukan bahwa nilai R² pada model regresi ke-3 (i.e., model interaksi antara stress akademik dan perilaku koping) meningkat sebesar 0,213 meskipun peningkatan ini tidak signifikan. Peneliti menyimpulkan bahwa perilaku coping tidak mampu menjadi moderator dalam hubungan antara stres akademik dan kesejahteraan subjektif
Psychological Well-Being pada Mahasiswa Santri Ditinjau dari Dukungan Sosial & Stress Akademik
Authors: Zahrah Ninda Alza Nur , Sukirno Rita Setyani Hadi 
Published: January 2023

Santri students are individuals who simultaneously study at universities and Islamic boarding schools. Students are vulnerable to experiencing academic stress caused by the burden of responsibility to carry out knowledge in two places and demands for academic achievement. The purpose of this study is to ascertain how social support and academic stress relate to the psychological well-being of santri students. Three research instruments and a quantitative methodology were employed in this study. In this study, 200 santri students from Special Region of Yogyakarta served as the sample. Employing Pearson product moment correlation analysis approaches for quantitative analysis. According to the study's findings, social support and academic stress significantly influence psychological well-being, with a combined effective contribution of 47,4%. Academic stress was negatively connected with psychological well-being (p=0,001) and favorably correlated with social support (p=0,001), with an effective contribution of 25,7% for each independent variable, according to an analysis of each independent variable. Mahasiswa santri adalah individu yang secara sekaligus menuntut ilmu di perguruan tinggi dan pondok pesantren. Mahasiswa rentan mengalami stres akademik yang disebabkan oleh beban tanggung jawab untuk mengemban ilmu di dua tempat dan tuntutan prestasi akademik. Ketersediaan dukungan sosial yang dimiliki juga dapat mempengaruhi tinggi-rendahnya tingkat psychological well-being mahasiswa santri. Tujuan dari penelitian ini adalah mengetahui hubungan psychological well-being mahasiswa santri ditinjau dari dukungan sosial dan stress akademik. Metode kuantitatif digunakan sebagai metode penelitian. Terdapat 200 mahasiswa santri di Daerah Istimewa Yogyakarta yang menjadi sampel sampel penelitian. Instrument yang digunakan ada 3 skala. Kemudian teknik analisis korelasi pearson product moment digunakan sebagai analasis data penelitian. Menurut output penelitian, dukungan sosial dan stres akademik memiliki dampak yang cukup besar terhadap psychological well-being, dengan sumbangan efektif sebesar 47,4%. Analisis masing-masing variabel independen menunjukkan bahwa stres akademik berhubungan negatif dengan kesejahteraan psikologis (p=0,001), dengan sumbangan efektif sebesar 25,7%. Sedangkan dukungan sosial berkorelasi positif dengannya (p=0,001), dengan kontribusi efektif sebesar 22,2%, menurut analisis masing-masing variabel independen.
Applied AI Solutions on Edge Devices
Authors: Harras Mohamed Salim , Saleh Shadi 
Published: January 2023

Call for submission. This editorial introduces the first issue of 2023 for Embedded Selforganising Systems (ESS) journal. The focus of this issue is the deployment of AI solutions in robotics and embedded systems.
Our journal uses electronic publication, which provides a flexible way to submit and review contributions of authors from all countries. The advantages of such an e-journal are multifarious. In comparison to traditional paper journals, we replace the classic review and creation process with a new sliding issue model. Each issue starts with an initial editorial and an official call for papers. The submitted articles will be reviewed and, if accepted, published as soon as the final version is received by the committee. Based on this process, each sliding issue can be filled successively until the maximum number of articles is reached. During this period, all accepted papers can, already be read by other researchers while other papers are still in the reviewing process. Accordingly, the time to publish shrinks to a minimum. In addition, multiple issues with different focus can co-exist at the same time, which provides completely new possibilities to react on latest research topics. The journal also allows the integration of discussions and other reactions on published articles in the same journal issue.
We are welcoming fresh ideas, on-going research technical reports and novel scientific works. We also intend to create a promising platform for creative and constructive discussions.
Current Situation of The Digital Transformation of The Mongolian Education Sector
Authors: Altangerel Munkhmagnai , Banzragch Buyandelger , Sed Sanjaabadam 
Published: January 2023

Digital learning is a comprehensive, innovative approach to the provision and management of education. In order to incorporate this approach into our education system, there is a need for the capacity building of human resources, incorporate distance education resources, adapt curricula and teaching methodologies to distance education, enhance students’ and instructors’ digital capacities, plan and develop a comprehensive open University system and diligently research the potential risks that are posed to our students’ and instructors’ wellbeing, privacy and security as a result of the digital transformation.
Policies and programs such as Mongolia’s “Sustainable Development Goals”, “Vision 2050 – Mongolia’s long-term development policy”, “Digital Society medium-term program 2022-2027”, “2020 – 2024 Mongolian Government operational program”. “Medium-term Education Sector Development Plan” have established the legal environment for the incorporation of digital technologies into the education sector.
As a result of the Covid-19 pandemic that has ravaged the world since 2019 a dire need to transform the development strategies, plans and education arose in countries across the world. Attempts to prevent and minimize the spread of Covid-19 further necessitated the development and conduct of online and hybrid classes and we have been using digital technologies to maximize the effectiveness of education in the New Normal.
The purpose of this paper is to determine the issues facing the digital transformation of education in terms of management, organization, curriculum, content, methodology, digital competencies of specialists, infrastructure, online resources, as well as education financing and propose solutions to some of the key issues.
Serum bicarbonate stability study at room temperature – influence of time to centrifugation and air exposure on bicarbonate measurement reported according to the CRESS checklist
Authors: Šupak-Smolčić Vesna , Franin Lucija , Horvat Mihovil , Šonjić Pavica , Svatić Rebeka , Antončić Dragana , Aralica Merica , Metzner Dara , Šimac Maja , Bilić-Zulle Lidija 
Published: January 2023

Abstract

Objectives
The aim was to evaluate the stability of serum bicarbonate at room temperature, depending on time to centrifugation and air exposure.

Methods
Stability study was conducted in the laboratory of Clinical Hospital Centre Rijeka, Croatia in January-February 2022. Nine samples from 10 volunteers were collected in clot activator gel tubes (Greiner Bio-One). Bicarbonate was measured on Beckman Coulter AU480 (Beckman Coulter, Brea, USA). Three tubes were left at room temperature for 30 min, three tubes for 2 h, three tubes for 4 h until centrifugation. First tube from first group (baseline) was measured immediately after centrifugation. Other measurements were expressed as percentage deviation (PD%) from baseline. First tube was remeasured after 1 and 2 h (OT_0h_1h; OT_0h_2h). Second and third tubes were opened 1 and 2 h after centrifugation (C_0h_1h; C_0h_2h). Second group of tubes was processed the same way with 2-hour centrifugation delay (WB_2h; OT_2h_1h; OT_2h_2h; C_2h_1h; C_2h_2h), and third group with 4-hour delay (WB_4h; OT_4h_1h; OT_4h_2h; C_4h_1h; C_4h_2h). PD% was compared to Maximum Permissible Difference (MPD=5.69%). MedCalc statistical software was used (MedCalc, Ostend, Belgium).

Results
Bicarbonate baseline mean value (range) was 27.3 (23.4–29.6) mmol/L. Obtained PD% (95%CI) were: C_0h_1h 0.46 (−1.21, 2.12); C_0h_2h 0.18 (−2.22, 2.57); OT_0h_1h −6.46 (−7.57, −5.36); OT_0h_2h −10.67 (−12.13, −9.21); WB_2h −0.15 (−2.04, 1.74); C_2h_1h 0.01 (−1.52, 1.54); C_2h_2h −0.40 (−2.65, 1.85); OT_2h_1h −5.43 (−7.30, −3.55); OT_2h_2h −11.32 (−13.57, −9.07); WB_4h −0.85 (−3.28, 1.58); C_4h_1h −2.52 (−4.93, 0.11); C_4h_2h −3.02 (−5.62, 0.43); OT_4h_1h −7.34 (−9.64, −5.05); OT_4h_2h −11.85 (−14.38, −9.33).

Conclusions
Serum bicarbonate is stable for 4 h in closed uncentrifuged tubes, another 2 h in closed tubes after centrifugation, and is unstable within 1 h in opened tube.
How do students apply the octet rule and how do they justify this application?
Authors: Keller David , Hermanns Jolanda 
Published: January 2023

Abstract
In this paper we describe an intervention study on the application of the octet rule. This study was conducted at a German University with students in their first- and second undergraduate year. As repeatedly observed by us before, the evaluation of the study confirmed that the students have difficulties with the application of the octet rule in general, but above all for charged molecules. After an intervention, which consisted of a detailed checklist for the application of the octet rule and training opportunities, the students’ competences increased, especially for the tasks which included charged molecules. Students’ explanations were not as good as expected; the linguistic quality did not increase significantly from pre-to post-test. This is not surprising, because the training of argumentation skills was not part of the intervention. The intended goal, training the application of the octet rule, has been achieved.