bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lymphoid cell rich fine-needle aspirations of the salivary gland: What is the risk of malignancy?
Authors: Krishnan Vimal , Victor Aaron R. , Bose Shikha , Bakkar Rania 
Published: May 2023

Objectives:
Lymphoid cell rich fine-needle aspirations (FNAs) of the salivary glands pose a diagnostic dilemma, with a wide range of differential diagnoses that include several benign and malignant entities. There is limited literature regarding the entities that are commonly encountered in this situation. Our goal was to characterize the surgical outcome in these cases and to evaluate the risk of malignancy.

Material and Methods:
This is a retrospective study at a tertiary care institution. Our database was queried over a 10-year period. FNAs yielding a prominent population of well-visualized lymphoid cells were included in the study. Only cases with surgical follow-up were evaluated. FNAs with epithelial cells, diagnostic features of any entity (such as granulomas or chondromyxoid stroma), history of metastatic malignancy, or scant cellularity were excluded from the study. Lymphoid cells were classified as atypical according to morphologic findings (monomorphism, irregular nuclear contours, and abnormal chromatin patterns). Statistical analysis was performed.

Results:
Of the 224 lymphoid cell rich FNAs identified, 29 (28%) had surgical follow-up in our data records. Twenty-two were from the parotid and seven from the submandibular gland. Ten cases (35%) were non-neoplastic (benign lymphoepithelial cyst [n = 4], reactive lymph node [n = 5] and chronic sialadenitis [n = 1]). Benign epithelial neoplasms including pleomorphic adenoma (n = 2) and Warthin’s tumor (n = 1) were identified in 10% of the cases. One case with non-atypical lymphocytes proved to be a mucoepidermoid carcinoma (n = 1). Lymphomas were detected in 52% (n = 15). Of note, none of these patients had a history of lymphoid malignancy. 8/15 were low-grade and 7/15 were high-grade lymphoma. Most of these cases (11/15) had atypical lymphocytes on FNA. Ancillary studies were available in a few cases and supportive of the diagnosis of lymphoma, including cell block and immunohistochemistry (n = 7, 47%), flow cytometry (n = 3, 27%), and clonality polymerase chain reaction (PCR) (n = 1; 7%). Most of these were performed in cases with atypical lymphocytes. In cases with non-atypical lymphocytes, five cases were malignant on surgical excision (5/17). Morphology on FNA had a specificity of 92% for malignancy and sensitivity of 69%. The positive predictive value on FNA of atypical lymphocytes for malignancy was 92%.

Conclusion:
Lymphoid cell rich FNAs carry a 52% incidence rate lymphoma in our small study population. Specificity of FNA for malignancy is high (92%) and lymphocyte atypia is a strong predictor of malignancy. Ancillary studies may be of added value in FNAs with non-atypical lymphoid cells. FNA has a valuable role in triaging lymphoid lesions of the salivary glands.
Temas de Direito Contemporâneo - Volume 4
Authors: Moraes Alan Jeffeson Lima de , Sousa Patrícia de Cássia Barros de , dos Santos da Silva Amanda 
Published: May 2023

Este livro reúne as pesquisas feitas pelos acadêmicos do Curso de Direito da Faculdade Anhanguera de São Luís/MA. Trata-se do primeiro passo rumo a uma longa trajetória de incentivo à produção científica dos alunos do curso, oportunizando a publicação dos Trabalhos de Conclusão do Curso em uma edição rica de temas variados na área do Direito.
Multimodal approach to pain management in thoracic surgery
Authors: Poniatovska H. , Dubrov S. 
Published: May 2023

The American Cancer Society estimated that 68,820,000 men and 61,360,000 women in the United States of America would die from lung and bronchial cancer in 2022, which is equal to 21% of all cancer deaths. Patients who undergo thoracotomy have a higher risk of postoperative complications due to the severe pain syndrome that typically develops after surgery. Even though there has been extensive research on the advantages and disadvantages of various perioperative analgesia techniques, the search for the best and safest still continues.
Objective — to improve the results of perioperative anesthesia in patients undergoing thoracotomy by choosing the optimal method of analgesia.
Materials and methods. A total of 59 patients with lung cancer who underwent thoracotomy at the communal non‑profit enterprise «Kyiv City Clinical Hospital No 17» from 2018 to 2020 were included in an open‑label noncommercial randomized controlled clinical trial. Patients were divided into 2 groups: the multimodal analgesia (MA) group (32 patients) and the epidural analgesia (EA) group (27 patients). According to the concept of preemptive analgesia, patients in the MA group received 1000 mg of paracetamol and 50 mg of dexketoprofen intravenously 1 hour before surgery. In the postoperative period, dexketoprofen and paracetamol were administered every 8 hours in combination with epidural analgesia. During postoperative epidural analgesia, patients received 40 mg of a 2% lidocaine solution through a catheter inserted into the epidural space (Th5—Th6) and a ropivacaine 2 mg/mL (3—14 mL/h) infusion. Patients in the EA group received only epidural analgesia in the postoperative period. After placement of an epidural catheter in the epidural space (Th5—Th6), they had an injection of 40 mg of a 2% lidocaine solution and an epidural infusion of ropivacaine 2 mg/ml (3—14 mL/h).
Results. The study groups did not demonstrate a statistically significant difference in terms of age, hight, weight, a grade of anesthesiological risk (ASA), blood loss, surgery duration, and surgical volume (р >0,05). The level of analgesia was assessed using the numerological rating scale (NRS) after 3, 6, 24, and 32 hours after surgery. Every research stage revealed a significant difference in the level of pain syndrome between the study groups (p<0.05). Patients in the EA group experienced more severe pain syndrome than those in the MA group. Consequently, 7 patients (26%) in the EA group were anesthetized with morphine 10 mg intramuscularly compared to 3 patients (9%) in the MA group.
Conclusions. In patients undergoing thoracic surgery, a multimodal analgesic approach, which includes the use of COX‑2 and COX‑3 inhibitors in combination with epidural analgesia, has been shown to produce better analgesia compared to epidural anesthesia alone. The beneficial effect of multimodal analgesia was seen in a significant difference (p<0.05) in the intensity of pain syndrome between the study groups in the early postoperative period after thoracotomy.
Keystone perforator island flaps in the reconstruction of lower limb defects resulting from shrapnel and mine-explosive combat injuries. Case series
Authors: Sliesarenko S. V. , Badiul P. A. , Rudenko O. I. , Romanshuk M. I. 
Published: May 2023

In the conditions of warfare in Ukraine, the question of providing medical services to injured civilian and military is especially relevant and severe. In plastic surgeons` professional activities, the task is to restore extensive and deep wound defects in a short term and with a high degree of damaged organ`s restoration, especially supporting function. In this article the authors describe their experience with local keystone perforator island flaps, which are used to reconstruct skin and soft tissue defects of the lower limbs caused by combat injuries.
Patients and methods. The authors conducted a retrospective review of 49 keystone perforator flaps for 28 patients (26 men and 2 women) who received treatment in the clinic for bullet, shrapnel, and mine‑explosive injuries between 2014 and 2022.
Results. In all cases, extensive wound defects were completely closed during a single‑stage surgical procedure, and the patients were discharged after recovery. Non‑critical complications required secondary sutures in two cases (4%), extending the duration of treatment by 6 days. The time spent in the operating room on the transposition of one flap ranged from 40 to 95 min (mean: 67 min).
Conclusions. The findings of the study show that local keystone perforator island flaps are highly effective in the successful reconstruction of lower limb defects caused by combat wounds. The keystone perforator island flap technique requires basic preoperative preparation of the patient, is easy‑to‑use, and exhibits a fairly high level of reliability at the same time. In most cases, keystone perforator island flaps provide primary and single‑stage closure of a large defect in the thigh, in the area of the knee joint, and in the lower leg in the absence of secondary defects that are common at donor sites when alternative techniques are chosen.
PENGARUH GAYA KEPEMIMPINAN DAN FASILITAS KERJA TERHADAP KINERJA Studi Kasus Pegawai DPUPR Kabupaten Indramayu
Authors: Renaldi  , Rahayuningsih Nurjanah , Rahayuningsih Nurjanah 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh Gaya Kepemimpinan dan Fasilitas Kerja terhadap Kinerja Pegawai pada Dinas Pekerjaan Umum dan Penataan Ruang (DPUPR) Kabupaten Indramayu. Penelitian ini menggunakan metode deskriptif dan asosiatif. Data dalam penelitian ini diperoleh dengan observasi, wawancara, dan angket/kuesioner dalam bentuk pernyataan yang dibagikan kepada 60 responden dan keseluruhan merupakan pegawai tetap Dinas Pekerjaan Umum dan Penataan Ruang (DPUPR) Kabupaten Indramayu.
Berdasarkan hasil analisis yang diperoleh dari analisis koefisien korelasi antara Gaya Kepemimpinan (X1) terhadap Kinerja (Y) diperoleh hasil bahwa koefisien korelasi korelasi Gaya Kepemimpinan (X1) terhadap Kinerja (Y) termasuk ke dalam kategori kuat sebesar 0,603. Hasil analisis koefisien korelasi antara Fasilitas Kerja (X2) terhadap Kinerja (Y) diperoleh bahwa hasil analisis koefisien korelasi Fasilitas Kerja (X2) terhadap Kinerja (Y) termasuk ke dalam kategori rendah sebesar 0,285.
Berdasarkan hasil perhitungan hipotesis Gaya Kepemimpinan (X1) terhadap Kinerja (Y) dengan menggunakan uji t terdapat pengaruh yang signifikan antara Gaya Kepemimpinan terhadap Kinerja sebesar 5,75 > t-tabel 2,00. Berdasarkan hasil perhitungan hipotesis Fasilitas Kerja (X2) terhadap Kinerja (Y) dengan menggunakan uji t terdapat pengaruh yang signifikan antara Fasilitas Kerja terhadap Kinerja sebesar 2,26 > t-tabel 2,00.
Workplace policies and quality of working life (QoWL) during the COVID-19 pandemic in Jordanian hospitals
Authors: Alyahya Mohammad S. , Momani Salam , Alolayyan Main Naser , Khader Yousef S. 
Published: May 2023

BACKGROUND: Many healthcare organizations place a high value on quality of work-life (QoWL). The healthcare system’s long-term sustainability and capability to offer high-quality services to patients depend on improving QoWL for their healthcare workers. OBJECTIVE: The study aimed to explore the impact of Jordanian hospitals’ workplace policies and measures in three main domains: (I) Infection prevention and control (IPC) measures, (II) Supply of personal protective equipment (PPE), and (III) COVID-19 precautionary measures on the QoWL among healthcare workers during the COVID-19 pandemic. METHODS: A cross-sectional survey was conducted from May to June 2021 through an online self-reported questionnaire (Google Form) targeting hospital healthcare professionals working at Jordanian hospitals (public, private, military, and university). The study used a valid work-related quality of life (WRQoL) scale to study the QoWL. RESULTS: A total of 484 HCWs in Jordanian hospitals participated in the study with a mean age of (34.8 ± 8.28 years). 57.6% of the respondents were females. 66.1% were married, with 61.6% having children at home. An average QoWL among healthcare workers in Jordanian hospitals during the pandemic was observed. The study results also showed a significant positive correlation between workplace policies (IPC measures, supply of PPE, and COVID-19 preventive measures) and the WRQoL among healthcare workers. CONCLUSION: Our findings highlighted the vital need for QoWL and psychological well-being support services for healthcare staff during pandemics. Improved IPC systems and other precautionary measures at the national and hospital management levels are required to help minimize the stress and fear that healthcare workers experience and lower the risk of COVID-19 and future pandemics.
Use of non-steroidal anti-inflammatory drugs in renal transplant patients: A retrospective study
Authors: Sridharan Kannan , Shah Shamik 
Published: May 2023

BACKGROUND: Renal transplants are often prescribed non-steroidal anti-inflammatory drugs (NSAIDs) for analgesic purposes. OBJECTIVE: Considering the dearth of data, we carried out the present study to evaluate the use of various NSAIDs and the incidence of acute kidney injury (AKI) in transplant patients. METHODS: A retrospective study amongst renal transplant patients prescribed at least one dose of NSAID was carried between January and December 2020 at the Department of Nephrology, Salmaniya Medical Complex, Kingdom of Bahrain. The patients’ demographic details, serum creatinine values, and drug-related details were obtained. The Kidney Disease Improving Global Outcomes (KDIGO) criteria were used for defining AKI. RESULTS: Eighty-seven patients were included. Forty-three patients were prescribed diclofenac, 60 received ibuprofen, six received indomethacin, 10 were administered mefenamic acid, and 11 received naproxen. Due to multiple courses of NSAID prescription, a total of 70 prescriptions were identified for diclofenac, 80 for ibuprofen, six for indomethacin, 11 for mefenamic acid, and 16 for naproxen. No significant differences were observed in the absolute (p = 0.08) and percent changes in serum creatinine (p = 0.1) between the NSAIDs. Twenty-eight (15.2%) courses of NSAID therapy met the KDIGO criteria for AKI. Age (OR: 1.1, 95% CI: 1.007, 1.2; p = 0.02), concomitant everolimus (OR: 483, 95% CI: 4.3, 54407; p = 0.01), and mycophenolate + cyclosporine + azathioprine (OR: 63.4E+006, 95% CI: 203.2157 to 19.8E+012; p = 0.005) administration were observed with significant risk of NSAID-induced AKI. CONCLUSION: We observed possible NSAID-induced AKI to an extent of around 15.2% in our renal transplant patients. No significant differences were observed in the incidence of AKI between various NSAIDs and none of them had either graft failure or death.
МЕТОДИКА ПРОЄКТУВАННЯ ЕЛЕКТРОННИХ НАВЧАЛЬНИХ КУРСІВ ДЛЯ СИСТЕМИ ПРОФЕСІЙНО-ТЕХНІЧНОЇ ОСВІТИ У ВОЄННИЙ ТА ПОВОЄННИЙ ЧАС
Authors: Зуєва Альона 
Published: May 2023

Актуальність: сучасні умови провадження освітньої діяльності актуалізували дистанційне та змішане навчання; більшість педагогічних працівників закладів професійної освіти обрали платформу Google Classroom та інструмент для відеоконференцій Google Meet для забезпечення навчального процесу, однак нема єдиної методики проєктування електронних навчальних курсів з використанням цих цифрових інструментів.
Мета: визначення основних складових та етапів методики проєктування електронних навчальних курсів для професійної освіти.
Методи: аналіз – для визначення стану розробленості проблеми; узагальнення – для формулювання висновків щодо основних складових та етапів методики проєктування електронних навчальних курсів для професійної освіти.
Результати: встановлено, що 84,4 % педагогічних працівників закладів професійної освіти проводили заняття та надавали завдання з використанням платформи Google Classroom, а 74,5 % опитаних для організації відеоконференцій обрали Google Meet. Методика проєктування електронних навчальних курсів для змішаного навчання в системі професійної (професійно-технічної) освіти у воєнний та повоєнний час опирається на цифрові інструменти середовища Google Workspace for Education, оскільки ними користуються більшість педагогічних працівників закладів професійної освіти. Ці інструменти легкі в застосуванні, адаптивні, враховують різні умови та технічні можливості учасників навчального процесу, дають змогу врахувати індивідуальні особливості та навчальні потреби учнів.
Українські педагоги та вчені виділяли від чотирьох до восьми етапів проєктування електронних навчальних курсів, і визначали різне функціональне наповнення цих етапів.
Методика проєктування електронних навчальних курсів для змішаного навчання має п’ять основних етапів (ADDIE: Analysing, Designing, Developing, Implementing, Evaluating), розширених та адаптованих для потреб змішаного навчання в закладах професійної освіти у воєнний та повоєнний час.
Висновки: Методика проєктування електронних навчальних курсів для змішаного навчання в системі професійної (професійно-технічної) освіти у воєнний та повоєнний час визначається як сукупність взаємопов’язаних методів, форм і засобів розроблення електронного навчального курсу в середовищі Google Workspace for Education. Вона має п’ять основних етапів проєктування ADDIE, з врахуванням педагогічних процесів, необхідних для змішаного навчання в закладах професійної освіти у воєнний та повоєнний час.
Ця методика дає можливість розроблення чіткого алгоритму взаємодії між викладачами й учнями, організації та супроводу педагогічних процесів в електронному навчальному курсі, врахування особливостей навчального процесу та індивідуальних особливостей учнів.
Microchasm
Authors: Bos Aja 
Published: May 2023

For this piece, I decided to create an inkblot using the traditional Japanese art method of Suminagashi. Suminagashi involves dropping blots of ink into a pan of water and alternatively dropping dots of soap into the ink. The ink is adverse to the soap and will disperse away from it. After repeating this process continuously, rings of ink form in the water. These rings can be blown on and manipulated to form patterns. When the pattern is satisfactory, the artist dips their paper into the pan, thereby transferring the ink pattern to the paper. The result is a gray-to-black scale of ink patterns. This piece reflects my views on truth. I feel the truth moves as a unit. To me truth is not wholly black and white, and it does not completely conform to one shape or pattern. It is gray, and changes shape, and can be hard to pin down. I think there is a lot to be considered when we think about how our truths impact the lives of others. It is never too late to consider both sides of the story.
Dynamic Viscosity Prediction of Blends of Paving Grade Bitumen with Reclaimed Bitumen
Authors: Rosta Szabolcs , Gáspár László 
Published: May 2023

The recycling of reclaimed asphalt pavement is of significant economic and environmental benefits. In this case, however, the satisfactory performance of the final product needs scientific planning of the mixture and thorough quality control. Before its use, a number of tests must be performed to verify that the binder meets the relevant requirements and can be used in asphalt mixtures. The binder characteristics in the reclaimed asphalt pavement and the expected properties of the binder blend in the new asphalt mixture must be known. For its prediction and calculation, a European standard offers the calculation of the penetration or softening point of the binder blend in the mixture with reclaimed asphalt content. However, in some countries, the determination of paving grade bitumen types (categories) is based not on dynamic viscosity measured with DSR instrument, so other validated test and calculation methods are in force. A viscosity-based method has not yet been validated for paving grade bitumens standardized on a penetration basis, although this method is more advantageous in many aspects when monitoring daily production processes; it is much shorter and requires less material than measuring softening point or penetration. The article deals with the measurement of the dynamic viscosity of bitumen blends of asphalt mixtures made using reclaimed asphalts, determined with a dynamic shear rheometer at different frequencies (0.1–10.0 Hz sweep). Furthermore, the relationships between the different composition ratios of national paving grade bitumens classified on the bases of penetration level and bitumens from reclaimed asphalt pavement are examined.
Importancia de la histopatología en el diagnóstico del Distemper canino o moquillo
Authors: Cabascango Martínez Lucía Vanessa 
Published: May 2023

Introducción: el virus del Distemper canino causa una enfermedad de gran letalidad en un amplio espectro de huéspedes, incluyendo animales que pertenecen al orden Carnívora, y debido a la existencia de un gran número de hospederos susceptibles, la inmunización a través de la vacunación sistemática es la única medida profiláctica eficaz para su control, aunque igualmente se han producido brotes ocasionales de la enfermedad en animales vacunados. La infección puede provocar una variedad de presentaciones clínicas, afectando los sistemas respiratorio, gastrointestinal, tegumentario y nervioso. Siendo la manifestación neurológica más común la encefalomielitis y sus signos clínicos pueden ser variados, debido al daño que el virus provoca tanto en la sustancia blanca como en la gris del sistema nervioso. Objetivo: identificar la importancia de la histopatología en el diagnóstico del Distemper Canino, conocer los principales hallazgos patológicos presentes en los pacientes con esta enfermedad de origen viral, analizar la importancia de un buen diagnóstico en el Distemper canino. Metodología: revisión bibliográfica de literatura. Resultados: se evidencio neurodegeneración en caninos infectados naturalmente, tanto en animales vacunados como en no vacunados, evaluando presencia, intensidad y distribución de las lesiones causadas por el virus en cerebro y cerebelo. Conclusiones: con respecto a las lesiones histopatológicas, el hallazgo constante es la desmielinización, además de la presencia de gliosis, leptomeningitis, manguitos perivasculares, necrosis y cuerpos de inclusión en varios cortes histológicos, siendo estos hallazgos más severos en el cerebelo; es así como este trabajo evidencia la importancia de la Histopatología en el diagnóstico del Distemper canino o Moquillo. Área de estudio general: Medicina Veterinaria. Área de estudio específica: Microbiología / Anatomía Patológica.
Workshop Penulisan Penelitian Tindakan Kelas untuk Guru SMA Negeri 1 Bengkulu Tengah
Authors: Stiadi Elwan , Putra Ari 
Published: May 2023

Penelitian Tindakan Kelas (PTK) adalah salah satu upaya yang dapat dilakukan seorang guru profesional dalam peningkatan kualitas pembelajaran. Pelatihan penulisan PTK dalam kegiatan pengabdian ini bertujuan untuk: (1) Meningkatkan pemahaman guru-guru SMA Negeri 1 Bengkulu Tengah tentang PTK, dan (2) Meningkatkan kemampuan guru dalam penulisan laporan PTK. Metode yang digunakan dalam kegiatan pengabdian adalah metode ceramah dan demonstrasi. Metode ceramah untuk menyampaikan prinsip-prinsip PTK, prosedur PTK, implementasi PTK, dan prosedur penulisan laporan PTK, sedangkan metode demonstrasi untuk memberikan kesempatan berlatih kepada peserta mempraktekkan mulai dari penyusunan masalah dalam proses pembelajaran yang dapat dipecahkan melalui PTK, rancangan proposal PTK, hingga penulisan laporan PTK. Kegiatan pengabdian secara keseluruhan dapat dinilai cukup baik, dilihat dari keberhasilan target jumlah peserta pelatihan dinilai cukup baik (73,33%), ketercapaian tujuan pelatihan dinilai kurang baik (40,9%), ketercapaian target materi yang telah direncanakan dinilai baik (80%), dan kemampuan peserta dalam penguasaan materi dinilai baik (80%).