bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does an educational video for aneuploidy screening improve informed choice among pregnant women? A randomised controlled trial
Authors: Xian Lim Karen Mei , Lewis Celine , Wong Hung Chew , Chong Glenda Sze Ling , Gosavi Arundhati , Choolani Mahesh Arjandas 
Published: December 2022

AbstractBackgroundPoor knowledge and the lack of deliberation have been cited as reasons for women making uninformed choices about aneuploidy screening. Adequate pre‐test counselling is of particular importance where non‐invasive prenatal screening (NIPS) is being increasingly offered as a primary screening test.DesignWomen attending the antenatal clinic with a singleton pregnancy below 14 weeks were randomised to receive routine counselling or the intervention—a 16‐min educational video on aneuploidy screening before their consult. The primary outcome, rate of informed choice, was assessed using an adapted multidimensional measure of informed choice questionnaire, where informed choice was defined as good knowledge and value‐consistent behaviour. Secondary outcomes included informed choice with deliberation, decisional conflict and anxiety.ResultsTwo hundred and eighty‐six women were recruited. 69.8% of women in the intervention group made an informed choice compared with 53.6% in the control group (Risk Ratio [RR] 1.30, p = 0.014). A significantly higher number of women in the intervention group had good knowledge compared to controls (81% vs. 60.9%; RR 1.33, p = 0.001). Decisional conflict did not differ between groups, but women in the intervention group had higher anxiety scores (p < 0.001).ConclusionThe study intervention was effective in helping women make informed choice. Qualitative studies to determine the reason for increased anxiety are needed.Trial registrationTrial registry: ClinicalTrials.gov; Identifier: NCT05492981.
Registration of ‘CP 14‐1490’ sugarcane
Authors: Momotaz Aliya , Baltazar Miguel , Coto Arbelo Orlando , Davidson R. Wayne , Islam MD S. , Sandhu Hardev , Zhao Duli , Sood Sushma , Gordon Vanessa S. 
Published: December 2022

Abstract‘CP 14‐1490’ (Reg. no. CV‐212, PI 700785), a sugarcane (a complex hybrid of Saccharum spp) cultivar, was developed through cooperative research conducted by the USDA‐ARS, the University of Florida, and the Florida Sugar Cane League, Inc. The Florida Sugarcane Variety Committee released CP 14‐1490 in June 2021 to growers for commercial cultivation on organic (muck) soils. It originated from a cross made at Canal Point (CP) on 29 Nov. 2011, where ‘CP 04‐1844’ (PI 664935) was the female parent, and the male parent was ‘CPCL 02‐8021’. CP 14‐1490 was released for its high sugar yields; acceptable commercial recoverable sucrose (though it had significantly lower cane yield at the second ratoon); resistances to Sugarcane mosaic virus strain E (mosaic) and ratoon stunt disease (caused by Clavibacter xyli subsp. xyli Davis et al.); moderate resistances to brown [caused by Puccinia melanocephala (H. & P. Sydow)] and orange rusts [caused by Puccinia kuehnii (Kruger) E. Butler], and leaf scald [caused by Xanthomonas albilineans (Ashby) Dowson]; and moderate susceptibility to smut [caused by Sporisorium scitamineum (Syd., M. Piepenbr., M. Stoll & Oberw)]. Yield data of CP 14‐1490 and reference checks (i.e., ‘CP 00‐1101’ [PI 651881], ‘CP 96‐1252’ [PI 634935], ‘CPCL 05‐1201’ [PI 672485]) were collected from 15 harvests (i.e., three crop cycles [plant cane, first and second ratoon] at five organic‐soil locations in final‐stage replicated yield trials. There was no significant difference in cane yield with all tested reference checks and no significant difference in sugar yield with CP 00‐1101 and CPCL 05‐1201. When compared to CP 96‐1252, CP 14‐1490 had significantly (P ≤ .05) higher sucrose yield (19.2%) and commercial recoverable sucrose (5%). CP 14‐1490 rated moderately tolerant to freezing among 23 tested genotypes.
Conditional gene regulation models demonstrate a pro‐proliferative role for growth hormone receptor in prostate cancer
Authors: Unterberger Christopher J. , McIlwain Sean J. , Tsourkas Philippos K. , Maklakova Vilena I. , Prince Jordyn L. , Onesti Abigail , Hu Rong , Kopchick John J. , Swanson Steven M. , Marker Paul C. 
Published: December 2022

AbstractBackgroundHumans with inactivating mutations in growth hormone receptor (GHR) have lower rates of cancer, including prostate cancer. Similarly, mice with inactivating Ghr mutations are protected from prostatic intraepithelial neoplasia in the C3(1)/TAg prostate cancer model. However, gaps in clinical relevance in those models persist. The current study addresses these gaps and the ongoing role of Ghr in prostate cancer using loss‐of‐function and gain‐of‐function models.MethodsConditional Ghr inactivation was achieved in the C3(1)/TAg model by employing a tamoxifen‐inducible Cre and a prostate‐specific Cre. In parallel, a transgenic GH antagonist was also used. Pathology, proliferation, and gene expression of 6‐month old mouse prostates were assessed. Analysis of The Cancer Genome Atlas data was conducted to identify GHR overexpression in a subset of human prostate cancers. Ghr overexpression was modeled in PTEN‐P2 and TRAMP‐C2 mouse prostate cancer cells using stable transfectants. The growth, proliferation, and gene expression effects of Ghr overexpression was assessed in vitro and in vivo.ResultsLoss‐of‐function for Ghr globally or in prostatic epithelial cells reduced proliferation and stratification of the prostatic epithelium in the C3(1)/TAg model. Genes and gene sets involved in the immune system and tumorigenesis, for example, were dysregulated upon global Ghr disruption. Analysis of The Cancer Genome Atlas revealed higher GHR expression in human prostate cancers with ERG‐fusion genes or ETV1‐fusion genes. Modeling the GHR overexpression observed in these human prostate cancers by overexpressing Ghr in mouse prostate cancer cells with mutant Pten or T‐antigen driver genes increased proliferation of prostate cancer cells in vitro and in vivo. Ghr overexpression regulated the expression of multiple genes oppositely to Ghr loss‐of‐function models.ConclusionsLoss‐of‐function and gain‐of‐function Ghr models, including prostatic epithelial cell specific alterations in Ghr, altered proliferation, and gene expression. These data suggest that changes in GHR activity in human prostatic epithelial cells play a role in proliferation and gene regulation in prostate cancer, suggesting the potential for disrupting GH signaling, for example by the FDA approved GH antagonist pegvisomant, may be beneficial in treating prostate cancer.
Untargeted lipidomics reveals lipid metabolism disorders induced by oxathiapiprolin in Phytophthora sojae
Authors: Liu Xiaofei , Li Chengcheng , Chen Yue , Xue Ziwei , Miao Jianqiang , Liu Xili 
Published: December 2022

AbstractBackgroundOxathiapiprolin, an oxysterol‐binding protein inhibitor (OSBPI), shows unexceptionable inhibitory activity against plant pathogenic oomycetes. FRAC (Fungicide Resistance Action Committee) classifies it into the mode of action group F9 (lipid homeostasis and transfer/storage), but very little is known about the lipid metabolism of oomycete pathogens when subjected to oxathiapiprolin.ResultsIn this study, seven lipid categories and 1435 lipid molecules were identified in Phytophthora sojae, among which glycerolipids, glycerophospholipids, and sphingolipids account for 30.10%, 50.59%, and 7.28%, respectively. These lipids were categorized into 31 subclasses, which varied to different extents when treated with oxathiapiprolin. A total of 11 lipid subclasses showed significant changes. Among them, 10 lipid subclasses, lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), phosphatidylcholine (PC), phosphatidylserine (PS), ceramide (Cer), triglyceride (TG), (o‐acyl)‐1‐hydroxy fatty acid, diglycosylceramide, sphingoshine (So), and sitosterol ester, were significantly up‐regulated, while digalactosyldiacylglycerol was the only lipid that was significantly down‐regulated by a factor of almost three. These lipid molecules were further analyzed at the lipid species level. A total of 542 species were significantly altered when treated with oxathiapiprolin, including 212 glycerolipids [186 TG and 26 diglycerides (DG)], 167 glycerophospholipids (38 PC, 15 LPC, 19 LPE, seven PS, etc.), 156 sphingolipids (146 Cer, four So, etc.), and some other lipid molecules. Finally, from the orthogonal partial least‐squares discrimination analysis model, variable importance for the projection score analysis showed that Cer, TG, and some glycerophospholipids contribute to the metabolic disorder when subjected to oxathiapiprolin.ConclusionGlycerolipids, glycerophospholipids, and sphingolipids in P. sojae undergo significant changes with oxathiapiprolin treatment. These results provided valuable information for further understanding the function of the target protein and the mode of action of OSBPIs in oomycetes. © 2022 Society of Chemical Industry.
Catecholase Activity of a Mn(III) Complex: An Approach through1H‐NMR spectroscopy
Authors: Rekha Tripathy Rashmi , Jana Samaresh , Kumar Maji Sanjoy , Sarkar Sohini 
Published: December 2022

AbstractA mononuclear Mn(III) complex, [MnIIIL(Cl)], has been synthesized using a newly explored Schiff base ligand, H2L. Both of them have been characterized by single crystal X‐ray crystallography, UV‐Vis spectroscopy and IR spectroscopy. Interestingly the complex behaved as a model of catechol oxidase toward oxidation of 3,5‐Di‐tert‐butyl catechol to the corresponding quinone. The progress of the oxidation process has been monitored with the help of 1H‐NMR spectroscopy after stirring the reaction mixture in methanol for 2 hours, 24 hours, 36 hours and 48 hours at room temperature. NMR spectral data confirmed completion of the process after 48 hours. Kinetic investigations were carried out in two different solvents, methanol‐water mixture and acetonitrile to check the effect of solvent on the rate of reaction, if any. A greater turnover number was obtained in acetonitrile than methanol‐water medium.
Inserting Single‐Atom Zn by Tannic Acid Confinement To Regulate the Selectivity of Pd Nanocatalysts for Hydrogenation Reactions
Authors: Zhang Sha‐Sha , Yi Jun , Cao Tai , Guan Jian‐Ping , Sun Jia‐Qiang , Zhao Qin‐Ying , Qiu Ya‐Jun , Ye Chen‐Liang , Xiong Yu , Meng Ge , Chen Wei , Lin Zhou , Zhang Jian 
Published: December 2022

AbstractPrecisely controlling the selectivity of nanocatalysts has always been a hot topic in heterogeneous catalysis but remains difficult owing to their complex and inhomogeneous catalytic sites. Herein, an effective strategy to regulate the chemoselectivity of Pd nanocatalysts for selective hydrogenation reactions by inserting single‐atom Zn into Pd nanoparticles is reported. Taking advantage of the tannic acid coating‐confinement strategy, small‐sized Pd nanoparticles with inserted single‐atom Zn are obtained on the O‐doped carbon‐coated alumina. Compared with the pure Pd nanocatalyst, the Pd nanocatalyst with single‐atom Zn insertion exhibits prominent selectivity for the hydrogenation of p‐iodonitrobenzene to afford the hydrodeiodination product instead of nitro hydrogenation ones. Further computational studies reveal that the single‐atom Zn on Pd nanoparticles strengthens the adsorption of the nitro group to avoid its reduction and increases the d‐band center of Pd atoms to facilitate the reduction of the iodo group, which leads to enhanced selectivity. This work provides new guidelines to tune the selectivity of nanocatalysts with guest single‐atom sites.
Boosting the Areal Capacity of Titanium‐Manganese Single Flow Battery by Fe2+/Fe3+ Redox Mediator
Authors: Nan Mingjun , Wu Min , Liu Yuqin , Qiao Lin , Zhang Huamin , Ma Xiangkun 
Published: December 2022

AbstractAqueous manganese‐based flow batteries (AMFBs) have attracted great attention due to the advantages of low cost and environmental friendliness. Extending the cycle life of AMFBs has long been a challenging theme. The titanium‐manganese single‐flow batteries (TMSFB) are promising due to their special structure and electrolyte composition. However, TMSFB with high areal capacity faces capacity decay for unknown reasons. In this work, the capacity decay mechanism (accumulation and growth of MnO2) is clarified by a homemade in situ microscope system. Given that, a redox mediator of Fe2+/Fe3+ is specially designed to boost the areal capacity of TMSFB without side reaction. The directional promoting principle of the Fe2+/Fe3+ is elaborated in detail. Fe2+ chemically reacts with the residual MnO2 to form Fe3+, which is reduced to Fe2+ by the electrochemical reaction. And then Fe2+ continues reacting with MnO2 until MnO2 is consumed completely. As a result, the TMSFB with the areal capacity of ≈55 mA h cm−2 can stably operate at a current density of 40 mA cm−2, which is the highest areal capacity reported in aqueous manganese‐based batteries. This work provides a new strategy for boosting the capacity of manganese‐based batteries, shedding light on the improvement of other deposition‐type batteries.
Bacteria‐Inspired Aqueous‐in‐Aqueous Compartmentalization by In Situ Interfacial Biomineralization
Authors: Yuan Hao , Li Fei , Jia Lufan , Guo Ting , Kong Tiantian , Meng Tao 
Published: December 2022

AbstractCompartmentalization is essential for living cells to orchestrate their biological processes with controlled external influences. Thus, compartmentalization has been a constant theme for cell‐mimicking materials. Despite recent advances in engineering compartmentalized materials as synthetic cells and organelles, it remains difficult to produce robust and well‐ordered compartments with secluded environments in aqueous surroundings. Nature creates hierarchically ordered compartmentalized materials by utilizing bio‐catalyzed mineralization, inspired by which, mechanically robust all‐aqueous compartments are developed by engineering a mild biomimetic mineralization at aqueous/aqueous interfaces. The enzyme‐induced biomineralization generates a layer of densely‐packed particles, acting as an armor to enclose aqueous interiors. This strategy of in situ bio‐synthesized compartments is different from current strategies, where compartments are constructed by randomly adsorbed particles at interface, leading to inadequately controlled properties of compartments. To demonstrate the robustness and adaptiveness of the in situ bio‐synthesized all‐aqueous compartments, these are utilized as drug delivery materials by sequestering protein drugs at their aqueous interiors and releasing when exposing to gastric environments. The study provides new ways to fabricate compartmentalized materials with well‐defined properties, unlocking routes to the next generation of self‐assembled materials and structures by integrating aqueous two‐phase systems with biomineralization.
Resummation and cancellation of the VIA source in electroweak baryogenesis
Authors: Postma Marieke , van de Vis Jorinde , White Graham 
Published: December 2022

Abstract
We re-derive the vev-insertion approximation (VIA) source in electroweak baryogenesis. In contrast to the original derivation, we rely solely on 1-particle-irreducible self-energy diagrams. We solve the Green’s function equations both perturbatively and resummed over all vev-insertions. The VIA source corresponds to the leading order contribution in the gradient expansion of the Kadanoff-Baym (KB) equations. We find that it vanishes both for bosons and fermions, both in the perturbative and in the resummed approach. The non-existence of the source is a result of a cancellation between different terms in the KB equations, and persists after resumming the masses.
The unpolarized and polarized single-mass three-loop heavy flavor operator matrix elements Agg,Q and ∆Agg,Q
Authors: Ablinger J. , Behring A. , Blümlein J. , De Freitas A. , Goedicke A. , von Manteuffel A. , Schneider C. , Schönwald K. 
Published: December 2022

AbstractWe calculate the gluonic massive operator matrix elements in the unpolarized and polarized cases,Agg,Q(x, μ2) and ∆Agg,Q(x, μ2), at three-loop order for a single mass. These quantities contribute to the matching of the gluon distribution in the variable flavor number scheme. The polarized operator matrix element is calculated in the Larin scheme. These operator matrix elements contain finite binomial and inverse binomial sums in MellinN-space and iterated integrals over square root-valued alphabets in momentum fractionx-space. We derive the necessary analytic relations for the analytic continuation of these quantities from the even or odd Mellin moments into the complex plane, present analytic expressions in momentum fractionx-space and derive numerical results. The present results complete the gluon transition matrix elements both of the single- and double-mass variable flavor number scheme to three-loop order.
Bootstrapping the a-anomaly in 4d QFTs
Authors: Karateev Denis , Marucha Jan , Penedones João , Sahoo Biswajit 
Published: December 2022

Abstract
We study gapped 4d quantum field theories (QFTs) obtained from a relevant deformation of a UV conformal field theory (CFT). For simplicity, we assume the existence of a ℤ2 symmetry and a single ℤ2-odd stable particle and no ℤ2-even particles at low energies. Using unitarity, crossing and the assumption of maximal analyticity we compute numerically a lower bound on the value of the a-anomaly of the UV CFT as a function of various non-perturbative parameters describing the two-to-two scattering amplitude of the particle.
Effect of metformin as an adjuvant therapy to letrozole on estradiol and other biomarkers involved in the pathogenesis of breast cancer in overweight and obese postmenopausal women: a pilot study
Authors: El-attar Aya Ahmed , Ibrahim Osama Mohamed , Alhassanin Suzan Ahmed , Essa Enas Said , Mostafa Tarek Mohamed 
Published: December 2022

Abstract
Introduction
Metformin may provide a therapeutic benefit in different types of malignancy.

Purpose
We aimed at evaluating the effect of metformin as an adjuvant therapy to letrozole on estradiol and other biomarkers involved in the pathogenesis of breast cancer in overweight and obese postmenopausal women.

Methods
Seventy-five postmenopausal stages II–III breast cancer female patients were assessed for eligibility in an open-labeled parallel pilot study. Forty-five patients met the inclusion criteria and were assigned into three arms: the lean arm (n = 15) women who received letrozole 2.5 mg/day, the control arm (n = 15) overweight/obese women who received letrozole 2.5 mg/day, and the metformin arm (n = 15) overweight/obese women who received letrozole 2.5 mg/day plus metformin (2000 ± 500 mg/day). The intervention duration was 6 months. Blood samples were obtained at baseline and 6 months after intervention for the measurement of serum estradiol, leptin, osteocalcin levels, fasting blood glucose concentration, and serum insulin.

Results
After the intervention and as compared to the control arm, the metformin arm showed a significantly lower ratio to the baseline (significant reduction) for estradiol (p = 0.0433), leptin (p < 0.0001), fasting blood glucose (p = 0.0128), insulin (p = 0.0360), osteocalcin serum levels (p < 0.0001), and the homeostatic model assessment of insulin resistance “HOMA-IR” value (p = 0.0145). There was a non-significant variation in the lactate ratio to the baseline among the three study arms (p = 0.5298).

Conclusion
Metformin may exert anti-cancer activity by decreasing the circulating estradiol, leptin, and insulin. Metformin might represent a safe and promising adjuvant therapy to letrozole in overweight/obese postmenopausal women with breast cancer.

Trial registration
ClinicalTrials.gov Identifier: NCT05053841/Registered September 23, 2021 - Retrospectively.
Suspension polymerization for synthesis of new hypercrosslinked polymers nanoparticles for removal of copper ions from aqueous solutions
Authors: Metwally Amal M. , ElKhawaga Hanaa A. , Shaaban Abdel-Fattah F. , Reda Laila M. 
Published: December 2022

AbstractNovel hypercrosslinked polymers nanoparticles (HCPNs) were designed by suspension polymerization technique with high surface area as well as HCPNs with functional groups have the affinity to removal of copper ions from aqueous solutions. Two HCPNs were synthesized through a two-step reaction, initially including the suspension polymerization of N-methacryloxytetrachlorophthalimide (NMTPA) with divinyl benzene (DVB) to give poly(NMTPA-co-DVB) and followed by the treatment of poly(NMTP-co-DVB) with triethylenetetramine (TETA) to give HCPNs (1) and with tetraethylenepentamine (TEPA) to give HCPNs (2). Using scanning electron microscopy and transmission electron microscopy, the surface morphology of the particles of the synthesized HCPNs was detected, and also, the particle size was measured. Also, the chemical structures of the synthesized compounds were illustrated by Fourier transform infrared spectroscopy and 1H-nuclear magnetic resonance (1H NMR). Thermal stability of the synthesized HCPNs was characterized by thermogravimetric analysis. The results illustrated that the particle size of the synthesized HCPNs is in range of 25–50 nm. The synthesized HCPNs compounds were reported for the separation of copper ions from wastewater, in which the results showed a very good affinity for these compounds for separation of copper ions from wastewater.
Geometric descriptors for the prediction of snowflake drag
Authors: Köbschall Kilian , Breitenbach Jan , Roisman Ilia V. , Tropea Cameron , Hussong Jeanette 
Published: December 2022

AbstractThe dynamics of solid particles of complex shapes such as airborne snowflakes are governed by aerodynamic drag forces that are a function of the relative velocity of the particle in the flow and the particle drag coefficient, which depends on the particle geometry and its orientation. In this study, artificial snowflakes are produced by additive manufacturing and their drag coefficients are obtained by measuring the terminal velocity in a liquid container, matching the Reynolds number typically encountered in natural occurrences. The experimental results show that the convex hull of the particle is suitable to accurately predict the drag force with existing correlations. Since it is unfeasible to accurately measure the three-dimensional geometries of natural snowflakes, the approximation with the convex hull provides a useful simplification. Furthermore, the known shapes of the artificial snowflakes are used to develop correlations to estimate the most relevant three-dimensional descriptors to predict the drag of snowflakes from a two-dimensional projection onto an arbitrary plane.
Graphic abstract
Uncertainty-aware visual analytics: scope, opportunities, and challenges
Authors: Maack Robin G. C. , Scheuermann Gerik , Hagen Hans , Peñaloza Jose Tiberio Hernández , Gillmann Christina 
Published: December 2022

AbstractIn many applications, visual analytics (VA) has developed into a standard tool to ease data access and knowledge generation. VA describes a holistic cycle transforming data into hypothesis and visualization to generate insights that enhance the data. Unfortunately, many data sources used in the VA process are affected by uncertainty. In addition, the VA cycle itself can introduce uncertainty to the knowledge generation process but does not provide a mechanism to handle these sources of uncertainty. In this manuscript, we aim to provide an extended VA cycle that is capable of handling uncertainty by quantification, propagation, and visualization, defined as uncertainty-aware visual analytics (UAVA). Here, a recap of uncertainty definition and description is used as a starting point to insert novel components in the visual analytics cycle. These components assist in capturing uncertainty throughout the VA cycle. Further, different data types, hypothesis generation approaches, and uncertainty-aware visualization approaches are discussed that fit in the defined UAVA cycle. In addition, application scenarios that can be handled by such a cycle, examples, and a list of open challenges in the area of UAVA are provided.