bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intended and Unintended Consequences of ERP System Implementation
Authors: Walton Stephanie , Wheeler Patrick , Zhang Yiyang 
Published: June 2023

SYNOPSIS
We provide evidence that enterprise resource planning (ERP) systems are potentially beneficial to firm decision-making but can also have unintended effects. The tax function is one of the largest consumers of data within a firm, with over 50 percent of time spent gathering tax data and less than 30 percent of time spent on strategic data analysis (PricewaterhouseCoopers (PwC) 2015). Difficulties in getting high-quality, timely tax information could negatively impact a firm’s tax compliance activities and leave few resources for tax planning. Following the absorptive capacity theory, we predict and find that ERP systems are associated with a greater degree of tax planning post-adoption, resulting in lower tax burdens. However, we also note increased firm discretion in tax planning, resulting in a larger amount of aggressive tax positions. Practically, our findings have important implications for the use of ERP systems both within the tax function and across other decision-making areas.
JEL Classifications: O33; H26; D83.
CEO Network Connections and the Timeliness of Financial Reporting
Authors: Islam Md Shariful , McCumber William , Farah Nusrat , Qiu Huan 
Published: June 2023

SYNOPSIS
We investigate the effects of CEO networks on the timeliness of financial reporting. Using a sample of over 2,000 firms for the period 2004–2017, we find that firms led by well-connected CEOs have lower earnings announcement lag, audit lag, and filing (10-K) lag. This timeliness is not at the expense of financial reporting quality and accuracy. These effects are stronger when firms have strong corporate governance and no material internal control weaknesses. Interestingly, the effect of CEO connectedness on timeliness is significant regardless of the intensity of demand for information from institutional investors and analysts but is stronger when information demand is lower. Overall, these findings suggest that improved information environment around well-connected CEOs leads to timely dissemination of high-quality information to the market.
JEL Classifications: D85; M42.
Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice
Authors: Chen Yi-Chun , Taylor Austin J. , Fulcher James M. , Swensen Adam C. , Dai Xiao-Qing , Komba Mitsuhiro , Wrightson Kenzie L.C. , Fok Kenny , Patterson Annette E. , Klein Geltink Ramon I. , MacDonald Patrick E. , Qian Wei-Jun , Verchere C. Bruce 
Published: June 2023

Carboxypeptidase E (CPE) facilitates the conversion of prohormones into mature hormones and is highly expressed in multiple neuroendocrine tissues. Carriers of CPE mutations have elevated plasma proinsulin and develop severe obesity and hyperglycemia. We aimed to determine whether loss of Cpe in pancreatic β-cells disrupts proinsulin processing and accelerates development of diabetes and obesity in mice. Pancreatic β-cell–specific Cpe knockout mice (βCpeKO; Cpefl/fl x Ins1Cre/+) lack mature insulin granules and have elevated proinsulin in plasma; however, glucose-and KCl-stimulated insulin secretion in βCpeKO islets remained intact. High-fat diet–fed βCpeKO mice showed weight gain and glucose tolerance comparable with those of Wt littermates. Notably, β-cell area was increased in chow-fed βCpeKO mice and β-cell replication was elevated in βCpeKO islets. Transcriptomic analysis of βCpeKO β-cells revealed elevated glycolysis and Hif1α-target gene expression. On high glucose challenge, β-cells from βCpeKO mice showed reduced mitochondrial membrane potential, increased reactive oxygen species, reduced MafA, and elevated Aldh1a3 transcript levels. Following multiple low-dose streptozotocin injections, βCpeKO mice had accelerated development of hyperglycemia with reduced β-cell insulin and Glut2 expression. These findings suggest that Cpe and proper proinsulin processing are critical in maintaining β-cell function during the development of hyperglycemia.

Article Highlights
Carboxypeptidase E (Cpe) is an enzyme that removes the carboxy-terminal arginine and lysine residues from peptide precursors. Mutations in CPE lead to obesity and type 2 diabetes in humans, and whole-body Cpe knockout or mutant mice are obese and hyperglycemic and fail to convert proinsulin to insulin. We show that β-cell–specific Cpe deletion in mice (βCpeKO) does not lead to the development of obesity or hyperglycemia, even after prolonged high-fat diet treatment. However, β-cell proliferation rate and β-cell area are increased, and the development of hyperglycemia induced by multiple low-dose streptozotocin injections is accelerated in βCpeKO mice.
Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism
Authors: Peterson Sean M. , Juliana Christine A. , Hu Cameron F. , Chai Jinghua , Holliday Carson , Chan Kara Y. , Lujan Hernandez Ana G. , Challocombe Zoe , Wang Linya , Han Zhen , Haas Nikhil , Stafford Ryan , Axelrod Fumiko , Yuan Tom Z. , De León Diva D. , Sato Aaron K. 
Published: June 2023

Congenital hyperinsulinism (HI) is a genetic disorder in which pancreatic β-cell insulin secretion is excessive and results in hypoglycemia that, without treatment, can cause brain damage or death. Most patients with loss-of-function mutations in ABCC8 and KCNJ11, the genes encoding the β-cell ATP-sensitive potassium channel (KATP), are unresponsive to diazoxide, the only U.S. Food and Drug Administration–approved medical therapy and require pancreatectomy. The glucagon-like peptide 1 receptor (GLP-1R) antagonist exendin-(9-39) is an effective therapeutic agent that inhibits insulin secretion in both HI and acquired hyperinsulinism. Previously, we identified a highly potent antagonist antibody, TB-001-003, which was derived from our synthetic antibody libraries that were designed to target G protein–coupled receptors. Here, we designed a combinatorial variant antibody library to optimize the activity of TB-001-003 against GLP-1R and performed phage display on cells overexpressing GLP-1R. One antagonist, TB-222-023, is more potent than exendin-(9-39), also known as avexitide. TB-222-023 effectively decreased insulin secretion in primary isolated pancreatic islets from a mouse model of hyperinsulinism, Sur1−/− mice, and in islets from an infant with HI, and increased plasma glucose levels and decreased the insulin to glucose ratio in Sur1−/− mice. These findings demonstrate that targeting GLP-1R with an antibody antagonist is an effective and innovative strategy for treatment of hyperinsulinism.

Article Highlights
Patients with the most common and severe form of diazoxide-unresponsive congenital hyperinsulinism (HI) require a pancreatectomy. Other second-line therapies are limited in their use because of severe side effects and short half-lives. Therefore, there is a critical need for better therapies. Studies with the glucagon-like peptide 1 receptor (GLP-1R) antagonist, avexitide (exendin-(9-39)), have demonstrated that GLP-1R antagonism is effective at lowering insulin secretion and increasing plasma glucose levels. We have optimized a GLP-1R antagonist antibody with more potent blocking of GLP-1R than avexitide. This antibody therapy is a potential novel and effective treatment for HI.
Stalin Era Intellectuals: Culture and Stalinism
Authors: Sandomirskaja Irina 
Published: June 2023

“It is pertinent to ask to what extent certain cultural phenomena and intellectual currents from the Stalin era really were such unique features that can be branded as Stalinist…”. This is the question that motivated the anthology Stalin Era Intellectuals: Culture and Stalinism under review here.
»Det är relevant att fråga sig i vilken utsträckning vissa kulturella fenomen och intellektuella strömningar från Stalintiden verkligen var sådana unika särdrag som kan stämplas som stalinistiska... ». Detta är frågan som motiverade antologin Stalin Era Intellectuals: Culture and Stalinism som granskas här.
Penyuluhan Konservasi Sumber Daya Hutan melalui Skema Hutan Kemasyarakatan (HKm)
Authors: Ariza Yudi Safril , Dewi Bainah Sari , Syahiib A. Nizam , Lestari Wulan Ayu , Violita Cindy Yoeland , Wahyuni Elza , Harianto Sugeng Prayitno , Winarno Gunardi Djoko 
Published: June 2023

Hutan kemasyarakat (HKm) merupakan salah satu skema perhutanan sosial yang tujuan utamannya adalah melakukan pengelolaan dan pemanfaatan hutan berbasis pemberdayaan masyarakat. Konsep ini bertujuan untuk memperkuat kelembagaan dan mempertahkan kelestarian SDA. Perlu adanya keterlibatan berbagai pihak dalam pelaksanaanya. Salah satunya adanya kegiatan penyuluhan untuk memberikan pemahaman dan pengetahuan kepada masyarakat khususnya dalam aspek konservasi lingkungan. Pengabdian ini bertujuan untuk mengetahui pemahaman dan peningkatan masyarakat terhadap kegiatan penyuluhan konservasi sumber daya hutan. Metode yang digunakan yaitu metode ceramah dan menggunakan analisis pre test dan post test untuk mengetahui peningkatan pemahaman peserta penyuluhan. Berdasarkan hasil kegiatan, terdapat peningkatan pemahaman peserta sebesar 20.09%. Peningkatan ini didasarkan pada kemampuan masyarakat menagkap materi yang disampaikan. Variabel yang mempengruhi terhadap peningkatan peserta yaitu pada aspek kelembagaan dan peran stakeholder. Namun, terdapat aspek yang mengalami peningkatan yang cukup rendah yaitu koservasi keanekarahaman hayati. Sehingga, perlu adanya upaya keberlanutan terhadap kegiatan dalam aspek praktik.
Peningkatan Pemahaman Masyarakat Tentang Alternatif Pemasaran Damar Mata Kucing (Shorea javanica): Studi Kasus Desa Pahmungan dan Pajar Bulan, Lampung Barat
Authors: Wulandari Christine , Erdian Zeda , Latifah Lutfi Nur , Fadli Nur Ahmad , Kurniawan Vinanda Arum Tri , Adinda Aryanti Rizki , Silaban Lusiana Tursina , Saputra Bagus , Rahmawaty Rahmawaty , Novasari Destia , Sari Dewi Rafika 
Published: June 2023

Damar mata kucing (Shorea javanica) merupakan salah satu hasil hutan bukan kayu (HHBK) yang telah banyak dikelola dan dimanfaatkan oleh masyarakat sekitar Desa Pahmungan dan Desa Pajar Bulan, Kabupaten Pesisir Barat, Provinsi Lampung. Penurunan minat masyarakat dalam mengelola repong damar salah satunya disebabkan oleh turunnya harga resin damar. Tujuan dari pengabdian kepada masyarakat (PKM) yang dilaksanakan pada tangga 21 – 23 Oktober 2022 ini adalah untuk meningkatkan pemahaman masyarakat tentang alternatif pemasaran damar agar mereka tetap memperoleh harga jual yang sesuai. Metode yang digunakan yaitu ceramah dan Focus Group Discussion (FGD). Peserta PKM sebanyak 11 orang adalah perwakilan tokoh masyarakat dari 2 desa Pahmungan dan Pajar Bulan. Hasil PKM menunjukkan bahwa pemasaran damar yang selama ini dilakukan oleh masyarakat masih secara konvensional. Di lokasi diketahui adanya satu saluran pemasaran damar yaitu dari petani – pengepul tingkat desa – PT Indo Gala Murni Pratama – Ekspor. Setelah diberikan ceramah oleh tim dosen dan mahasiswa Jurusan Kehutanan Fakultas Pertanian Universitas Lampung beserta mitra yang kemudian diikuti dengan FGD pengetahuan dan pemahamam masyarakat tentang pemasaran damar mata kucing meningkat. Lebih rinci, peningkatan pemahaman masyarakat yaitu tentang alternatif pemasaran damar berdasarkan kondisi pasar dan budidaya damar mata kucing. Berdasarkan hasil pre-test dan posr-test peningkatan pemahaman masyarakat terhadap kondisi pasar yaitu dari 52,73 menjadi 92,72 atau meningkat 39,99. Peningkatan pemahaman pada budidaya damar mata kucing yaitu 69,09 dan 98,18 atau meningkat 29,09.
Pandangan Tokoh Ulama Majelis Ulama Indonesia Terhadap “Fatwa Nikah Misyar Yusuf Al-Qardawi”
Authors: Wafiah Rafifatun Nida  
Published: June 2023

Nikah misyar merupakan nikah yang belum lazim pada saat ini, dimana istri melepaskan sebagian haknya yaitu untuk tidak menerima nafkah dari suaminya dan hanya menuntut nafkah batiniyah saja, Yusuf Al-Qardawi membukukan secara tersendiri perihal nikah misyar, nikah misyar sendiri saat ini masih jarang diperbincangkan oleh ulama di Indonesia karena masih tergolong degan nikah model baru bagaimana pandangan ulama MUI terhadap nikah misyar. Penelitian ini dilakukan dengan metode field research (penelitian lapangan), pengambilan data dalam penelitian ini di peroleh dengan menggunakan metode wawancara. Nikah misyar Yusuf Al-Qardawi menurut ulama MUI Kota Ponorogo dapat di kategorikan menjadi 2 ada yang membolehkan secara mutlak juga ada yang membolehkan dengan syarat, menurut Ulama MUI Ponorogo ada yang memperboleh kan karena pernikahan ini secara hukum memenuhi syarat dan rukun pernikahan, dan suatu kebolehan jika sang istri merelakan sebagian haknya yaitu nafkah lahiriyah dan hanya menuntut nafkah batiniyah, hal tersebut tidak membuat batalnya suatu pernikahan, sedangkan menurut Ulama MUI Ponorogo yang memperbolehkan dengan syarat walaupun baik rukun dan syaratnya sudah terpenuhi kita juga perlu mengetahui tujuan dan motif dilaksanakannya nikah misyar apakah demi kemaslahatan ataukah demi kemafsadatan, karena pada hakikatnya pernikahan adalah untuk mencapai sakinah, mawaddah, war-rahmah, dan nafkah adalah termasuk di dalamnya.
The relationship between the burnout syndrome and academic success of medical students: a cross-sectional study
Authors: Ilić Irena M. , Ilić Milena D. 
Published: June 2023

Abstract
The burnout syndrome may affect academic achievement, but research on burnout and academic success of medical students is sparse. This research aimed to estimate the prevalence of high risk of burnout in students of medicine and to investigate its association with academic performance. It included 760 full-time medical students who completed the survey (response rate = 90.9 %). A significant independent predictor for high burnout risk in students with lower grade point average (GPA) was male gender (adjusted OR=2.44; 95 % CI=1.14–5.23; P=0.022). Among students with higher GPA, high burnout risk was associated with the use of sedatives (adjusted OR=6.44; 95 % CI=1.80–22.99; P=0.004).
Antibiotic Resistance – Where are We Going?
Authors: Hryniewicz Waleria , Strużycka Izabella 
Published: June 2023

Abstract
Introduction of antibiotics into clinical practice is considered as a turning point in medicine resulting in saving millions of lives and allowing for the development of new fields of medicine such as transplantology, neonatology, hematology and many others. From the very beginning, this success was accompanied by the emergence of antibiotic resistant strains with its continuous rise. Overuse and misuse of antibiotics in medicine, veterinary practice and animal and plant production are the main reasons the resistance has emerged. Presently, an increase in isolation of multidrug resistant (MDR), excessively resistant (XDR) and pandrug resistant (PDR) bacteria is being observed worldwide in the most common human etiologic bacterial agents . As examples of rapid evolution of resistance, S. aureus and Enterobacterales producing extended-spectrum beta-lactamases are presented. Some initiatives of WHO and EU aiming to tackle antibiotic resistance are also discussed.
Alkhumra Hemorrhagic Fever Virus (AHFV): Current Status and Future Prospects
Authors: Azhar Leena Esam 
Published: June 2023

Abstract
The objective of this review to summarize the current status of information about the Alkhumra hemorrhagic fever caused by Alkhumra hemorrhagic fever virus an Arboviral infection. This virus was identified in Alkhumra district of Jeddah, Saudi Arabia in 1995 from a butcher patient. The infected individual develops symptoms febrile flu-like illness, hemorrhagic manifestations and less like encephalitis. Several cases have been reported from various locations of Saudi Arabia and a few from Egypt and is further expanding in tropical and subtropical regions of Western Asia. The virus is transmitted to human by direct contact to animal, raw meat, and biproducts as well as either tick or mosquito bites. Based on the recent status, a great concern of public health was raised with the AHFV epidemics and infection. Currently, there is no effective vaccine and antiviral therapeutics against AHFV. So, there is an urgent need to design and develop an effective preventive measure using interdisciplinary approach. This review will provide the status of research work based on the latest published information about AHFV. The provided information will be highly useful to design the effective preventive measures to control the disease in the Kingdom of Saudi Arabia.
CRISPR/Cas System: An Effective Tool Against Pathogenic Diseases
Authors: Aslam Shakira , Umair Ali , Aslam Zaid , Saleem Muhammad Zafar , Bashir Hamid 
Published: June 2023

Abstract
Viral pathogens are major concern nowadays. Bacterial CRISPR/Cas systems help in defending the host body against different pathogens including viruses too. This system contains restriction enzymes that introduce dsDNA breaks on target site to make the virus non-functional by damaging its genes. Coronavirus, HIV and Herpes viruses are causing mortality all around the world. To control the spread of disease, early detection and treatment is required. CRISPR system due to its high efficiency provides a platform to restrict the viral entry into host cell, viral genome editing and eliminate the latent infections. In this review, the CRISPR strategies against three major viral diseases are put under consideration: Coronavirus, Acquired Immunodeficiency Syndrome and Herpesvirus associated diseases. Three CRISPR/Cas systems have been discussed including CRISPR/Cas12, CRISPR/Cas9 and CRISPR/Cas13 that are used against the above listed viruses.
The Occurrence of Methicillin-Resistant Staphylococcus Aureus (MRSA) Around the World and Antibiotic Therapy for Selected Infections Caused By MRSA
Authors: Wierzchowska Kamila 
Published: June 2023

Abstract

Staphylococcus aureus is a Gram-positive bacterium, which can cause serious bacterial infections in humans. It constitutes an important etiological factor of many diseases, for instance, soft tissue and skin infections (including skin boils and abscesses), as well as life-threatening necrotizing pneumonia or toxic shock syndrome. It is estimated that about 25–30% of people are carriers of S. aureus mainly in the anterior nostrils. A smaller percentage of people are carriers of methicillin-resistant S. aureus (MRSA). In accordance with its definition, methicillin-resistant S. aureus is resistant to almost all β-lactam antibiotics. This phenomenon is mainly caused by the presence of penicillin-binding protein in the cell wall – PBP2a, which is the product of the mecA gene, which is part of the complex called SCCmec (staphylococcal cassette chromosome mec). Methicillin-resistant S. aureus (MRSA) results in endemic in hospitals around the world and are one of the leading causes of morbidity and mortality in society. Infections initiated by hospital strains of MRSA (health care-associated MRSA, HA-MRSA) concern mainly immunocompromised patients after surgery. In addition, there are populations of acommunity-associated MRSA (CA-MRSA) strains and populations of livestock-associated MRSA (LA-MRSA) strains. The treatment of infections with MRSA etiology, after exhausting the possibilities of standard antibiotic therapy with the use of i.e. vancomycin, is based on treatment with new-generation antibiotics, such as dalbavacin.
Beginner-Coaches and Connectivity of Knowledge: Real-World Coaching and Self-Reported Importance of Prior Playing Experience
Authors: Crisp Philippe , Hamblin May 
Published: June 2023

Abstract
In what amounts to essentially being a part two to our previous work with six beginner-coaches that found noticeable benefits to reflective practice, yet a number of possible drawbacks such as time constraints and at times over-focusing on negative emotions (Hamblin & Crisp, 2022), we build upon the aims of that study that related to what beginner-coaches (in recreational sport fields) considered ideal coach learning within in-situ, practice-based contexts. Through revisiting the data of the first study (Hamblin & Crisp, 2022) and exploring an additional theme related to how the beginner-coaches identified sporting experience as a beneficial prerequisite to their own coaching practice, the present study sought to further investigate, and build upon, the findings and aspects of the first study. Continuing to explore how beginner-coaches who operate more within recreational (although still competitive) sport fields perceive in-situ, ideal learning, and continuing the same methodological approach, the present study conducted semi-structured interviews with another five beginner-coaches, adding to the six in the first study for a total of 11 participants.
Transcriptions were analysed using thematic analysis and the themes found included sporting experience, traditional learning, and the benefits of reflective practice which highlights the ways all of the beginner-coaches (within both ‘part one’ and the present study – ‘part two’) felt they learn best. Importantly, these findings showed the self-reported importance of actually coaching (‘real world’ applications) and, of particular note, what were considered by the beginner-coaches to be the significant benefits of having accrued playing experience prior to starting coaching. These findings then may well provide further evidence to uphold and develop methods of coach education in the future to facilitate learning.
Reduced Cortical Thicknesses of Adolescents with Bipolar Disorder and Relationship with Brain-derived Neurotrophic Factor
Authors: İnal Neslihan , Cavusoglu Berrin , Ermiş Çağatay , Turan Serkan , Gormez Vahdet , Karabay Nuri 
Published: June 2023

Abstract

Background
Cortical thickness (CT) and brain-derived neurotrophic factor (BDNF) were widely investigated in bipolar disorder (BD). Previous studies focused on the association between the volume of subcortical regions and neurotrophic factor levels.

Objective
In this study, we aimed to evaluate the association of the CT in youth with early-onset BD with BDNF levels as a potential peripheral marker of neuronal integrity.

Method
Twenty-three euthymic patients having a clinical diagnosis of BD and 17 healthy subjects as an age-matched control group with neuroimaging and blood BDNF levels were found eligible for CT measurement. A structural magnetic resonance scan (MRI) and timely blood samples were drawn.

Results
Youth with BD exhibited lower cortical thickness in caudal part of left (L) middle frontal gyrus, right (R) paracentral gyrus, triangular part of R inferior frontal gyrus, R pericalcarine region, R precentral gyrus, L precentral gyrus, R superior frontal gyrus and L superior frontal gyrus when compared to healthy controls. The effect sizes of these differences were moderate to large (d=0.67-0.98) There was a significant correlation between BDNF levels with caudal part of the R anterior cingulate gyrus (CPRACG) in adolescents with BD (r=0.49, p=0.023).

Conclusion
As a special region for mood regulation, the CT of the caudal part of the R anterior cingulate gyrus had a positive correlation with BDNF. Regarding the key role of CPRACG for affective regulation skills, our results should be replicated in future follow-up studies, investigating a predictive neuroimaging biomarker for the early-onset BD.
ζ-Open Sets and ζ-Continuity
Authors: Sabah A. Tamer  , Taha H. Jasim  
Published: June 2023

In this work, the concept of ζ-Open Set was introduced as a generalization of open set. Where it is shown that (X, ) is a Topological Space.
Also, we study -Interior, -Closure, Continuity Function. At last basics Properties of them are given.