bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three patterns for identifying the posterior plane of a lenticule during SMILE
Authors: Zheng Ke , Wang Jing , Zheng Xiaohong , Han Yinan , Zhou Xingtao 
Published: June 2023

Abstract
Purpose
To describe three patterns of posterior plane edge identification in small-incision lenticule extraction and to prevent lenticule mis-dissection.

Methods
Femtosecond laser application was performed for small-incision lenticule extraction (SMILE) by one surgeon. The surgical videos of SMILE were recorded and re-watched by the surgeon after operation.

Results
Small-incision lenticule extraction was performed in 52 eyes of 28 patients, and no patient had cap-lenticular adhesion. Three patterns of posterior plane of lenticule were noticed when the surgical videos were re-watched. A “double lines” attached to the dissector were visible, signifying the reflective tape of the edge of the lenticule and the cap. During the expansion of the posterior lamellar separation, a fusiform opening between the lenticule edge and the underlying matrix layer was assumed to be a “leaf sign.” With some unintentional operation, the posterior lamella was pushed away from the surgeon. The edge of the lenticule away from the anatomical part, the marking of the femtosecond laser cut, and the edge of the cap layer showed three reflective bands, which formed a “triple lines.” The “double lines,” “leaf sign,” and “triple lines” were observed in 30 eyes (57.7%), 21 eyes (40.4%), and 1 eye (1.9%), respectively.

Conclusion
These three signs cover possible situations and provide visual landmarks to identify the correct dissection of the posterior plane, which can help shorten the learning curve of novice doctors.
Visual-Motor Integration Deficits in 3q29 Deletion Syndrome
Authors: Pollak Rebecca M. , Burrell T. Lindsey , Cubells Joseph F. , Klaiman Cheryl , Murphy Melissa M. , Saulnier Celine A. , Walker Elaine F. , White Stormi Pulver , Mulle Jennifer G. 
Published: June 2023

Abstract3q29 deletion syndrome (3q29del) is associated with neuropsychiatric and neurodevelopmental phenotypes. We previously reported that graphomotor weakness is present in up to 78% of individuals with 3q29del. We have now explored nuances of the graphomotor phenotype and its association with other comorbidities in this population. Participants were recruited from the online 3q29 registry (3q29deletion.org) for two days of deep phenotyping. 32 individuals with 3q29del (62.5% male) were evaluated with the Beery-Buktenica Developmental Test of Visual-Motor Integration (VMI) to assess visual-motor integration. Participants were also evaluated with measures of cognitive ability, executive function, adaptive behavior, and school function. Males with 3q29del performed significantly worse than females on the VMI and Motor Coordination subtest. VMI performance was significantly associated with ADHD diagnosis and cognitive ability. Compared to published data from individuals with 22q11.2 deletion syndrome, individuals with 3q29del showed significantly more impairment. The 3q29 deletion is associated with substantial deficits in visual-motor integration, Visual Perception, and Motor Coordination. Our data suggests that 3q29del may qualify as a nonverbal learning disability. Future studies should assess whether individuals with 3q29del would benefit from early interventions, including occupational therapy.
Screening of several microalgae revealed biopesticide properties of Chlorella sorokiniana against the strawberry pathogen Phytophthora cactorum
Authors: Jokel Martina , Salazar João , Chovancek Erik , Sirin Sema , Allahverdiyeva Yagut 
Published: June 2023

AbstractPresent agricultural production typically depends on the intensive use of synthetic pesticides with potentially harmful consequences for humans and the environment. To ensure food security for the rapidly rising global population it is necessary to develop more sustainable alternatives to synthetic pesticides. Microalgae possess a large diversity in antimicrobial compounds and are considered one of the most promising sustainable sources of novel biopesticides. Antimicrobial activities of 15 microalgae strains were investigated against a selection of seven common plant pathogens relevant to agricultural production. Several microalgae were identified posessing antimicrobial activity, with an extract of Chlorella sorokiniana showing the strongest growth inhibition of the plant pathogen Phytophthora cactorum. Different pre-treatments like freeze-drying, solvents with different polarities, and extraction methods were analyzed in regards to the level of antimicrobial activity of C. sorokiniana. The best C. sorokiniana extract demonstrated potential for biopesticide application on strawberry leaves infected with P. cactorum. This study reveals the potential of microalgae as natural biopesticide for organic or more sustainable regular agriculture.
The role of proline in the adaptation of eukaryotic microalgae to environmental stress: An underestimated tool for the optimization of algal growth
Authors: Barera Simone , Forlani Giuseppe 
Published: June 2023

AbstractMicroalgae are considered the most promising source of renewable fuels, high-value bio-products and nutraceuticals. Potentially, microalgae can satisfy many global demands, but in large-scale cultivation the average productivity of most industrial strains is lower than maximal theoretical estimations, mainly due to sub-optimal growth conditions. Although microalgae have developed complex strategies to cope with environmental stresses, cultivation in outdoor photobioreactors is limited to few species and it is not yet sufficiently remunerative. Indeed, most microalgal species are very sensitive to environmental conditions, and changes in solar irradiation, temperature, and medium composition can drastically decrease biomass yield. Developing new strategies for improving algal tolerance to stress conditions is thus greatly desirable. One of the first responses that occur in both higher plants and microorganisms following the exposure to abiotic stress conditions, is an increased synthesis and accumulation of the amino acid proline. While the role of proline accumulation in stress adaptation is well-recognized in higher plants, in microalgae the implication of proline in stress tolerance still awaits full elucidation. In this review we summarize available data on proline metabolism under environmental stress in eukaryotic microalgae. Possible implications toward optimization of algal growth for biotechnological purposes are also discussed.
Sensitivity of varve biogenic component to climate in eastern and central Finland
Authors: Salminen Sarianna , Saarni Saija , Saarinen Timo 
Published: June 2023

AbstractBiogenic varves as well as the biogenic component of clastic–biogenic varves have great potential as climate and environmental proxies but the response of biogenic lamina thickness to variations in growing-season climate is not well known. The connection of biogenic lamina thickness with growing-season or open-water season climate has been the focus of a limited number of studies. We examined biogenic laminae deposited during the past 100 years in five Finnish lakes representing different catchment types. We compared variations in biogenic lamina thicknesses with growing-season temperature records and open-water-season precipitation records. Statistical analyses for the whole study period reveal that the studied lakes generally respond positively to variations in growing-season temperature and open-water season precipitation. This suggests that warm summers intensify primary production while precipitation enhances transportation of allochthonous biogenic material and nutrients into the lake. Both mechanisms lead to enhanced biogenic lamina thickness. Two lakes reveal a more complex relationship to climate. Biogenic lamina thicknesses record a distinguishable climate signal despite human activities in the catchments, such as peatland drainage and forest cutting. We conclude that variations in biogenic lamina thickness of such boreal (clastic)–biogenic varves show potential for growing-season climate reconstructions. However, the response of each lake to climate parameters should be tested and understood separately.
Association of CDSS score and 60-day mortality in Chinese patients with non-APL acute myeloid leukemia: a retrospective cohort study
Authors: Zhong Huaqing , Chen Xianchun , Xiao Dejun , Luo Shi , Ji Yanhong , Xiao Zuomiao 
Published: June 2023

AbstractAcute myeloid leukemia (AML) is a heterogeneous hematological malignancy, and is one of the triggers of DIC, the latter is an essential factor in the early death of patients with AML. However, the timely identification of DIC remains a challenge. The Chinese DIC Scoring System (CDSS) is a common consensus widely used in China; but, there are few reports on its application in patients with AML. We undertake this retrospective cohort study to investigate the association between CDSS score and 60-day mortality. CDSS scores were evaluated after admission. The outcome was all-cause 60-day mortality. Multivariate Cox regression analyses were performed to calculate the adjusted hazard ratio (HR) and the corresponding 95% confidence interval (CI). Survival curves were plotted by Kaplan–Meier and log-rank analyses. Subgroup analyses were stratified by relevant effect covariates. A total of 570 consecutive patients with primary AML were included. We found an association between a 39% increase in 60-day mortality and a 1 point increase in CDSS score (HR = 1.39, 95% CI 1.25–1.54), which was associated with a 189% increase in 60-day mortality in CDSS scores ≥ 6 compared with that in the CDSS scores < 6 (HR = 2.89, 95% CI 1.91–4.38). After adjusting for all potential con-founders, a 27% and a 198% increase were observed (HR = 1.27, 95% CI 1.01–1.61; HR = 2.98, 95% CI 1.24–7.19), respectively. There is association between 60-day mortality and CDSS score in patients with AML. These findings may help hematologists in making informed treatment decisions.
Le monolithe. Gian-Carlo Rota et la déconstruction de la personnalité
Authors: Palombi Fabrizio 
Published: June 2023

Résumé
Le monolithe est la métaphore d’une interprétation de la personnalité humaine que Gian-Carlo Rota considère comme extrêmement périlleuse. Une partie de sa réflexion philosophique est consacrée à la critiquer, avec d’autres mythes répandus dans la culture con-temporaine. C’est une approche qui, sous certains aspects, peut être rapprochée de celle proposée par la déconstruction derridienne. L’article examine les occurrences et les acceptions du concept de « personnalité » dans les textes de Rota, afin de mettre en évidence l’influence de la psychanalyse existentielle et, plus généralement, celle de la réflexion phénoménologique de Jean-Paul Sartre. Dans cette perspective, le sens philosophique de ses brefs textes biographiques, inspirés par le style de Ennio Flaiano, et que Rota a consacré à quelques grands mathématiciens, sera éclairci.
Ambiguïté, infini, transcendance. Réflexions sur l’Évolution de la notion de nombre, après une lecture de Gilles Châtelet
Authors: André Yves 
Published: June 2023

Résumé
Pour Gilles Châtelet, « deux rythmes scandent l’“histoire des idées” : celui tout à fait discontinu des “coupures”, des paradigmes et de leurs réfutations, et celui des latences problématiques toujours disponibles à la réactivation et pleine de trésor » – en vue de laquelle il mobilise les notions cardinales de geste de pensée, stratagème allusif et virtualité.
Nous inspirant de ce point de vue, nous méditons sur l’évolution de la notion de nombre avec pour horizon la réactivation de la théorie des nombres transcendants, ensablée depuis quelques lustres ; soulignant « les latences problématiques », nous voyons cette évolution comme inséparable des deux thèmes de l’infini et de la symétrie. Alors que ces thèmes sont demeurés presque toujours disjoints, la réactivation de la transcendance pourrait dépendre d’une synthèse, dont nous esquis-sons les contours, encore flous, dans le cas d’une large famille de nombres appelés « périodes », selon une problématique initiée par Leibniz.
Gilles Châtelet, à contre-voix
Authors: Paoletti Catherine 
Published: June 2023

Résumé
Entendre le réel, avec et par la voix, ce qui ne cesse de ne pas s’écrire, c’est poser la question de et dans l’écriture. Une écriture instruite par une diagrammatique du montage, qui implique dans sa matérialité/immatérialité un rapport singulier au temps, à la voix, au sens, au recouvrement, aux croisements, à la transversalité, aux gestes de pensée, instruisant une véritable scène pour en élaborer les réserves propres, sous forme d’écriture spécifique : le sonore de l’écriture – cris, insurrection, soulèvement, révolution ou transport. Il ne s’agit rien de moins que de penser une politique de la voix et de ses usages contemporains à partir de Gilles Châtelet et Herbert Marcuse.
Human epidermal growth factor 2 overexpressed alpha-fetoprotein-producing-gastric cancer
Authors: Shimizu Hiroko , Kochi Mitsugu , Fujii Masashi , Watabe Megumu , Matsuno Yoritaka , Kawai Takaharu , Suda Hiroshi , Tanino Tomoyuki , Nakanishi Yoko , Masuda Shinobu , Okamura Yukiyasu 
Published: June 2023

Abstract
Purpose
This study aimed to elucidate the clinicopathological characteristics of α-fetoprotein (AFP)-producing gastric carcinoma (AFP-GC) with human epidermal growth factor receptor (HER)2 overexpression to extend the treatment strategy for AFP-GC.

Methods
We analyzed 41 patients with AFP-GC who underwent surgical resection or chemotherapy from 1989 to 2019, and who had over 20ng/mL of serum AFP or positive immunohistochemical AFP expression. HER2 expression status was investigated by immunohistochemistry (IHC) for all patients and by fluorescence in situ hybridization (FISH) for cases with an IHC score of 2+. AFP-GC with an IHC score of 3 + or 2 + and FISH positivity was defined as HER2 overexpressed AFP-GC. The correlation between HER2 status and clinicopathological characteristics and prognosis in AFP-GC was analyzed.

Results
HER2 overexpression was detected in 17.1% of AFP-GC patients. The prognosis of the patients with HER2 overexpressed AFP-GC was not significantly different compared to HER2 non-overexpressed AFP-GC. HER2 overexpressed AFP-GC consisted of heterogeneous histology with a higher proportion of mixed-type tumors (p = 0.002). The clinical outcome of AFP-GC with mixed-type of histology tended to be better than other intestinal or diffuse types (p = 0.05).

Conclusion
HER2 overexpressed AFP-GC consisted of a mixed type of histology, which showed a better prognosis. The results presented that HER2 status in AFP-GC is one of the molecular candidates to improve the prognosis.
The Taming of the Grounds
Authors: Saenz Noël Blas 
Published: June 2023

AbstractAs it is presently employed, grounding permits grounding many things from one ground. In this paper, I show why this is a mistake by pushing for a uniqueness principle on grounding. After arguing in favor of this principle, I say something about it and kinds of grounding, discuss a similar principle, and consider its import on a formal feature of grounding, ontology, and ontological simplicity.
Differences between Lyapunov exponents for the simple random walk in Bernoulli potentials
Authors: Kubota Naoki 
Published: June 2023

AbstractWe consider the simple random walk on the d-dimensional lattice
$\mathbb{Z}^d$
(
$d \geq 1$
), traveling in potentials which are Bernoulli-distributed. The so-called Lyapunov exponent describes the cost of traveling for the simple random walk in the potential, and it is known that the Lyapunov exponent is strictly monotone in the parameter of the Bernoulli distribution. Hence the aim of this paper is to investigate the effect of the potential on the Lyapunov exponent more precisely, and we derive some Lipschitz-type estimates for the difference between the Lyapunov exponents.
Electoral Systems and Geographic Representation
Authors: Carella Leonardo , Eggers Andrew 
Published: June 2023

AbstractWho gets represented in legislatures, and how does this depend on electoral institutions? Others have asked this question from the perspective of gender, race, and class. We focus on space, asking whether MPs disproportionately come from some places rather than others and how this depends on electoral rules. Using data on over 13,000 legislators in sixty-two democracies, we developed a new measure to determine whether the spatial distribution of MP birthplaces matched the spatial distribution of the citizens they represented. Contrary to received wisdom, single-member district systems do not have more geographically representative parliaments than multi-member district systems, while mixed-member systems perform significantly better than both. We attribute the higher spatial representativeness of mixed-member systems to the contamination effects in their single-member tier. We present evidence for this explanation from a within-country analysis of elections in Italy, the UK, and Germany.
How agricultural land use affects the abundance and prevalence of monoxenous and heteroxenous helminths in the generalist lizardTropidurus hispidus
Authors: Brasileiro Ana Carolina , Fernandes de Carvalho Elvis Franklin 
Published: June 2023

AbstractAmong the forms of anthropogenic disturbance, agricultural land use is one of the main threats to biodiversity. Understanding how interactions between parasites and hosts are affected by agricultural land use allows predictions of how these anthropogenic impacts affect parasites. Although parasitism patterns are affected by agricultural land use, it is noteworthy that different groups of parasites can respond differently to these environmental alterations. While heteroxenous species need more than one host to complete their life cycle and tend to be more harmed by anthropization, monoxenous species, which need only one host to complete their life cycle, tend to be less harmed. In this work, we evaluate how agricultural land use affects the abundance and prevalence of parasitism for monoxenous and heteroxenous helminths in the generalist lizardTropidurus hispidusin Caatinga Domain, Brazil. We recorded differences in abundance and prevalence of heteroxeneous (higher in conserved areas) and monoxenous helminths (higher in agricultural areas). Heteroxenous helminths that have lizards as definitive hosts are mainly obtained through diet.Tropidurus hispiduspredominantly consumes insects, so it is possible that the lower abundance and prevalence of heteroxenous parasites in agricultural areas, beyond habitat simplification, is related to the decrease in the insect population. As monoxenous species do not need an intermediate host, it is possible that this aspect has influenced their greater success in anthropogenic environments than heteroxenous species. This contrasting result reinforces the need for a separate assessment between these groups when evaluating effects of land use.
Comparative analysis of inflight transmission of SARS-CoV-2, influenza, and SARS-CoV-1
Authors: Luo Yingjie , Li Yuguo , Xiao Shenglan , Lei Hao 
Published: June 2023

Abstract
The aim of this study is to evaluate the infection risk of aircraft passengers seated within and beyond two rows of the index case(s) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A(H1N1)pdm09 virus, and SARS-CoV-1. PubMed databases were searched for articles containing information on air travel–related transmission of SARS-CoV-2, influenza A(H1N1)pdm09 virus, and SARS-CoV-1 infections. We performed a meta-analysis of inflight infection data. In the eight flights where the attack rate could be calculated, the inflight SARS-CoV-2 attack rates ranged from 2.6% to 16.1%. The risk ratios of infection for passengers seated within and outside the two rows of the index cases were 5.64 (95% confidence interval (CI):1.94–16.40) in SARS-CoV-2 outbreaks, 4.26 (95% CI:1.08–16.81) in the influenza A(H1N1)pdm09 virus outbreaks, and 1.91 (95% CI:0.80–4.55) in SARS-CoV-1 outbreaks. Furthermore, we found no significant difference between the attack rates of SARS-CoV-2 in flights where the passengers were wearing masks and those where they were not (p = 0.22). The spatial distribution of inflight SARS-CoV-2 outbreaks was more similar to that of the influenza A(H1N1)pdm09 virus outbreaks than to that of SARS-CoV-1. Given the high proportion of asymptomatic or pre-symptomatic infection in SARS-CoV-2 transmission, we hypothesised that the proximity transmission, especially short-range airborne route, might play an important role in the inflight SARS-CoV-2 transmission.
Endogenous estrogen receptor modulating oxysterols and breast cancer prognosis: Results from the MARIE patient cohort
Authors: Decker Nina Sophia , Johnson Theron , Behrens Sabine , Obi Nadia , Kaaks Rudolf , Chang-Claude Jenny , Fortner Renée Turzanski 
Published: June 2023

Abstract
Background
27-hydroxycholesterol (HC) and 25-HC were identified as endogenous selective estrogen receptor modulators (SERMs) and estrogen receptor (ER) modulators, respectively. They are hypothesized to play a role in multiple physiologic processes and pathologies, including breast cancer development and progression.

Methods
We evaluated circulating 27-HC and 25-HC, and outcomes following a breast cancer diagnosis in 2282 women from the MARIE study over median follow-up of 11.6 years. 27-HC and 25-HC were quantified by liquid chromatography–mass spectrometry. We calculated hazard ratios (HR) and 95% confidence intervals [CI] using multivariable Cox Proportional Hazards regression.

Results
We observed no associations between 27-HC and breast cancer prognosis overall. Associations between 27-HC and survival differed by circulating estradiol concentrations and endocrine therapy, but not by hormone receptor status. Among women with estradiol levels below the median (0.08 nM), 27-HC was associated with higher risk of all-cause mortality (HRlog2 = 1.80 [1.20–2.71]) and breast cancer-specific mortality (HRlog2 = 1.95 [1.14-3.31]). No associations were observed in women with estradiol levels above the median. Higher 25-HC levels were associated with lower risk of recurrence (HRlog2 = 0.87 [0.77-0.98]).

Conclusion
Associations between 27-HC and breast cancer prognosis varied by circulating estradiol levels and endocrine therapy. Less consistent results were observed for 25-HC.
Ab initio calculations on structure and stability of BN/CC isosterism in azulene
Authors: Abdel-Rahman Mohamed A. , Soliman Kamal A. , Abdel-Azeim Safwat , El-Nahas Ahmed M. , Taketsugu Tetsuya , Nakajima Takahito , El-Meligy Asmaa B. 
Published: June 2023

AbstractHerein, we investigated the thermodynamic stability and opto-electronic properties of a newly BN-doped azulene. The gas-phase formation enthalpies of 11 BN-doped azulene were calculated by the atomization energy method using three computational models (CBS-APNO, CBS-QB3, and G3MP2). The results suggest that AZ-1N9B exhibits the highest stability among the studied isomers. On the other hand, AZ-1B9N and AZ-9B10N display nearly equal stability with relative energies of 19.36 and 19.82 kcal/mol at CBS-QB3, respectively. These two isomers are considered the least stable among the investigated compounds. The frontier molecular orbitals (FMO), ionization energies (IE), and electron affinities (EA) of these isomers were discussed. Additionally, the electronic absorption spectra of the BN-doped azulenes were computed using the TD-B3LYP/6–31 + G(d,p) and TD-CAM-B3LYP level of theories, which using a long-range corrected hybrid functional in acetone. The computational results obtained in this research are align closely with the existing literature, thereby reinforcing the credibility and reliability of our findings.