bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surveillance of Vibrio parahaemolyticus pathogens recovered from ready-to-eat foods
Authors: Beshiru Abeni , Igbinosa Etinosa O. 
Published: March 2023

AbstractThis study examined the occurrence of V. parahaemolyticus from ready-to-eat (RTE) food in Delta State, Nigeria. It also characterized antibiotic resistance and virulence gene profile patterns to determine the associated health risk hazard. Food samples total of 380 were collected randomly and assessed for V. parahaemolyticus. V. parahaemolyticus isolates were characterized for their virulence and antibiogram potentials using a phenotypic and polymerase chain reaction (PCR) approach. A total of 42 (11.1%) samples were contaminated with V. parahaemolyticus. In 17/42 (40.5%) of the V. parahaemolyticus-positive samples, the densities were < 10 MPN/g. However, 19/42 (45.2%) and 6/42 (14.3%) of the samples had densities of 10 – 102 and > 102 MPN/g, respectively. A total of 67 V. parahaemolyticus isolates were identified using PCR; 54(80.6%) isolates were multidrug resistant. A total of 22 (32.8%), 39 (58.2%), and 67 (100%) of the V. parahaemolyticus harbored the tdh, trh, and tlh toxin genes, respectively. The T3SS1 gene (vcrD1) was detected in 67 (100%) of the isolates. The T3SS2α genes which were vcrD2, vopB2, and vopT were detected in 21 (31.3%), 11 (16.4%) and 30 (44.8%) of the isolates respectively. Some of the V. parahaemolytics strains harbored the orf8 gene 20 (29.9%), and a combination of orf8 + tdh genes 12 (17.9%), categorized as pandemic strains. The antibiotic resistance genes detected in this study include blaTEM 33 (49.3), tetM 19 (28.4), cmlA 32(47.8) and sul1 14 (20.9). The concentration levels and prevalence of V. parahaemolyticus in RTE foods indicate contamination of ready-to-eat foods, particularly street foods consumed in the Delta State of Nigeria, threatening public health and consumer safety.
TiO2–Ag–NP adhesive photocatalytic films able to disinfect living indoor spaces with a straightforward approach
Authors: Chirumbolo Salvatore , Gibellini Davide , Berto Luca , Cirrito Cinzia , Vella Antonio , Bjørklund Geir , Sbarbati Andrea , Bernardi Paolo , Tirelli Umberto 
Published: March 2023

AbstractTiO2–Ag doped nanoparticulate (TiO2–Ag–NP) adhesive photocatalytic films were used to assess the ability in dropping down the burden of indoor microbial particles. The application of an easy-to use photocatalytic adhesive film to cleanse indoor living spaces from microbial pollution, represents a novelty in the field of photocatalytic devices. Reduction was attained by photocatalysis in selected spaces, usually with overcrowding (≥ 3 individuals) in the common working daily hours, and upon indoor microclimate monitoring. TiO2–Ag doped nanoparticulate (TiO2–Ag–NP) adhesive photocatalytic films were applied within five types of living spaces, including schools and job places. The microbial pollution was assessed at time 0 (far from routine clean, ≥ 9 h) and throughout 2–4 weeks following the photocatalyst application by relative light unit (RLU) luminometry and microbial indirect assessment (colony forming units per cubic meter, CFU/m3). TiO2–Ag–NP photocatalyst reduced RLU and CFU/m3 by rates higher than 70% leading to RLU ≤ 20 and microbial presence ≤ 35 CFU/m3. The described TiO2–Ag–NP is able to reduce microbial pollution to the lowest RLU threshold (≤ 20) within 60 min in open daylight in a standardized test room of 100 m2. The correlation between RLU and CFU/m3 was positive (r = 0.5545, p < 0.05), assessing that the microbial reduction of indoor areas by the TiO2–Ag–NP adhesive film was real. Titania photocatalysts represent promising tools to ensure air cleaning and sanitization in living indoor microclimates with a low cost, feasible and straightforward approach. This approach represents an easy to handle, cost effective, feasible and efficacious approach to reduce microbial pollution in indoor spaces, by simply attaching a TiO2–Ag–NP adhesive film on the wall.
Online deep Bingham network for probabilistic orientation estimation
Authors: Li Wenjie , Liu Jia , Hao Wei , Liu Haisong , Ren Dayong , Wang Yanyan , Chen Lijun 
Published: March 2023

AbstractOrientation estimation is one of the core problems in several computer vision tasks. Recently deep learning techniques combined with the Bingham distribution have attracted considerable interest towards this problem when considering ambiguities and rotational symmetries of objects. However, existing works suffer from two issues. First, the computational overhead for calculating the normalisation constant of the Bingham distribution is relatively high. Second, the choice of loss functions is uncertain. In light of these problems, we present an online deep Bingham network to estimate the orientation of objects. We sharply reduce the computational overhead of the normalisation constant by directly applying a numerical integration formula. Additionally, we are the first to give theorems on the convexity and Lipschitz continuity of the Bingham distribution's negative log‐likelihood, which formally indicates that it is a proper choice of the loss function. We test our method on three public datasets, namely the UPNA, the T‐LESS and Pascal3D+, showing that our method outperforms the state‐of‐the‐art in terms of orientation accuracy and time efficiency, which can reduce the runtime by more than 6 h compared to the offline methods. The ablation experiments further demonstrate the effectiveness and robustness of our model.
A high speed reconfigurable architecture for softmax and GELU in vision transformer
Authors: Li Tianyang , Zhang Fan , Xie Guangwei , Fan Xitian , Gao Yanzhao , Sun Mingqian 
Published: March 2023

AbstractTransformers have been widely used in various computer vision applications. Compared to traditional convolutional neural networks (CNNs), transformer's inference includes plenty of non‐linear operations, such as softmax and Gaussian error linear units (GELU). As the scale of transformers grows, an efficient hardware implementation of these operations is significant. However, the current works of computer vision neural network accelerators focus on CNN and less attention is paid to transformer. In addition, most current FPGA‐based softmax or GELU accelerators are not designed for vision transformer (ViT). To solve this problem, this work proposes a high speed reconfigurable accelerator. The architecture can support both softmax and GELU functions in ViT by reconfiguring the data path. This architecture on Xilinx XCVU37P is implemented through mathematical transformation and hardware optimization design, and achieve the performance of 102.4 Giga bits per second (Gbps) at 200 MHz. Experimental results show that the architecture achieves a very small accuracy loss in the ViT's inference by using fixed‐point 16‐bit quantization. Compared with existing accelerators, the design has greater throughput and area efficiency.
Energy management system for islanded multi‐microgrids using a two‐stage optimization scheme based on political optimizer
Authors: Mahmoud Ibrahim , Hasanien Hany M. , Turky Rania A. , Omran Walid A. 
Published: March 2023

AbstractAn energy management system (EMS) is proposed in this paper to minimize the amount of load shedding in islanded multi‐microgrids (MMGs) systems in a cost‐effective manner. The suggested EMS adopts a two‐stage hierarchical optimization model. The first stage is called microgrid (MG) optimization, in which the load shedding in each MG is minimized. The day‐ahead schedule of the diesel generator, the charging/discharging power of the battery energy storage system (BESS), the reshaped load profile after applying the demand response programs (DRP), and the shortage/surplus power in each MG are determined in the first stage of optimization. The second stage is MMG optimization, in which the amount of energy shortage in the MMG system is further minimized by energy exchange between individual MGs. The remaining shortage can be reduced with the aid of the community MG resources. The proposed optimization model is formulated as a nonlinear complex optimization problem that can be handled more efficiently by the meta‐heuristic techniques compared with the conventional analytic methods. The political optimizer is used in this paper. To prove the effectiveness of this optimizer in handling the proposed model, we also solved the optimization problem using the particle swarm optimization algorithm, and results are compared.
A bi‐level multistage distribution network expansion planning framework with the cooperation of residential private investors (A case study in Iran)
Authors: Ashoornezhad Ali , Falaghi Hamid , Hajizadeh Amin , Ramezani Maryam 
Published: March 2023

AbstractIn recent years, supporting schemes have been legislated by several governments to encourage private investors in installing renewable energy resources (RER). In such cases, the supportive policies are mainly enacted based on the either investor or distribution companies’ standpoint. In this paper, a distribution network expansion planning (DNEP) framework with the cooperation of residential private investors (RPI) is proposed. Due to the presence of a couple of main participants, the proposed framework is arranged in a bi‐level framework, where the RPI participation is optimized at the upper level, and the system structure is determined at the lower level. In order to assess the profitability of the project from the investors’ attitude, payback period years (PBY) is utilized. Meanwhile, due to the presence of uncertainty resources, fuzzy clustering method (FCM) is developed to catch the intermittency of the problem. The proposed framework is implemented on a real 81 bus distribution test system in Iran. Moreover, the existing scheme in Iran and also a modified plan are investigated to make cost‐effective decisions. Finally, sensitivity analysis is performed to reach a more beneficial result. Obtained results demonstrated how distribution companies can utilize the potential of residential customers in long‐term planning.
Power supply circuit model and sliding mode control of supercritical unit boiler system commissioning
Authors: Ye Zhenqi , Lin Maosheng , Wei Lai 
Published: March 2023

AbstractIn the process of power control and commissioning of supercritical unit boiler system, there are some problems such as large steady‐state error and slow response speed. In order to optimize the control performance of supercritical unit boiler system, the power supply loop model and sliding mode control method of supercritical unit boiler system debugging power supply are proposed. Firstly, the power supply circuit model is established according to the data of voltage doubling rectifier circuit, inverter circuit, high frequency transformer and LC resonant circuit. Secondly, the capacitance voltage value and the inductance current value are calculated in the power supply circuit model. Finally, based on the numerical results, a terminal sliding mode controller and a linear sliding mode controller are established to complete the double closed‐loop terminal sliding mode control and realize the power control of the debugging power supply. The experimental results show that when the input voltage is 50 V and the current is 14 V, the input voltage and current waveforms remain stable. When the input voltage is between 40 and 50 V, the change of switching frequency is small, only increasing from 22 to 26 kHz. The steady state of the power supply is high, and when the input voltage increases, the DC offset is 21.2. The convergence time in the calculation process is less than 200 ms. The instantaneous change of inductance is 0.7 A. The steady‐state error is less than 0.005 V. The output voltage distortion rate is less than 4%. It is proved that this method has strong control performance in the supercritical unit boiler system.
Orthopäden und Internisten – Hand in Hand
Authors: Lembeck Burkhard , Betsch Kathrin , Bellm Michaela 
Published: March 2023

ZUSAMMENFASSUNGDie gesamte Versorgung chronisch-entzündlich-rheumatischer Systemerkrankungen sollte multidisziplinär ausgelegt sein, durch Einbindung von Haus- und Fachärzten1 sowie dem Patienten selbst und dessen Umfeld. Um diese verbesserte Versorgung anbieten zu können bedarf es deutlich mehr, als die Regelversorgung zu bieten hat. Baden-Württemberg hat die vielen Missstände des Systems erkannt und daher die Haus- und Facharztverträge ins Leben gerufen. Dazu hat der BVOU gemeinsam mit den Rheumaexperten BW eG sowie dem Berufsverband Deutscher Rheumatologen (BDRh) lange mit den Krankenkassen verhandelt, um den Vertrag zur Versorgung in den Fachgebieten Orthopädie und Rheumatologie zu entwickeln. Mittlerweile kann auf über 9 Jahre Versorgung im Fachgebiet Orthopädie und Unfallchirurgie und auf über 5 Jahre im Fachgebiet internistische Rheumatologie mit positiven Versorgungsergebnissen sowie zufriedenen Patienten und Ärzten zurückgeblickt werden. Neben keinerlei Fallzahl- und Mengenbegrenzungen werden umfassende Patientenberatungen sowie der Zugang zu modernster qualitätsgesicherter Diagnostik und Therapie entsprechend vergütet; all dies macht die verbesserte ganzheitliche Versorgung überhaupt erst möglich. Der Gesetzgeber sieht bisweilen noch keine Verpflichtung für solche besonderen Versorgungsformen wie die der Facharztverträge. Gemeinsam wird sich aber auf berufspolitischer Ebene weiter dafür eingesetzt.
Delegation in der Rheumatologie: Aktueller Stand und Perspektiven
Authors: Hoeper Juliana Rachel , Schuch Florian , Hoeper Kirsten 
Published: March 2023

ZUSAMMENFASSUNGDie rheumatologische Versorgung ist großen Herausforderungen ausgesetzt. Es stehen immer wirksamere Behandlungsmöglichkeiten zur Verfügung. Dem gegenüber steht jedoch eine Unterversorgung, die durch Mangel an Rheumatolog*innen, einer regionalen Ungleichheit und einer Fehlallokation ärztlicher Ressourcen hervorgerufen wird. Dies führt zu einer verspäteten Diagnosestellung und somit zu einem verspäteten Behandlungsbeginn. Seit einiger Zeit wird diskutiert, ob durch die Einbindung von qualifiziertem nichtärztlichem Personal Ressourcen effizienter genutzt werden können. Mittlerweile bestätigen Studien in Deutschland, dass die Delegation ärztlicher Leistung dazu beiträgt, der vorliegenden Unterversorgung ohne Qualitätsverlust zu begegnen. Um eine Implementierung in den Versorgungsalltag zu erreichen, müssen allerdings mehrere Aspekte in Betracht gezogen werden. Wesentliche Punkte sind hier, neben dem wissenschaftlichen Nachweis, die rechtlichen Rahmenbedingungen, Qualifikation des nichtärztlichen Personals sowie eine Finanzierung. Der vorliegende Beitrag gibt einen Überblick über den aktuellen Stand der Delegation ärztlicher Aufgaben in der Rheumatologie in Deutschland mit dem Ziel, die Chancen der Delegation aufzuzeigen.
Die Analyse-Synthese von C. M. Boger – Teil 1: Anleitung mit
zwei Kasuistiken
Authors: Tils Christoph 
Published: March 2023

ZusammenfassungC. M. Boger entwickelte eine Arbeitsweise aus einer einzigartigen großen
Synthese. Sie mündete in 2 sehr kondensierte Werke: den
„Synoptic Key“ und das nur 27 Seiten umfassende „General
Analysis“ (GA). Eng verbunden mit ihrer Herstellung und Anwendung ist
das universale Werkzeug der „Charakteristik“. Sie reicht von
Hahnemann, weiterentwickelt und stringent fortgeführt von
Bönninghausen und G. H. G. Jahr bis zu Bogers Synthese. Boger entdeckte
die größere Bedeutung der universellen „Allgemeinen
Charakteristika“, die nur aus Teilsymptomen bestehen. Anhand von 2
Kasuistiken wird gezeigt, wie man mit diesen 2 kompakten Boger-Werken auch mit
Lochkartei sehr effektiv arbeiten kann. Die vielseitigen „Allgemeinen
Charakteristika“ ermöglichen die Kombination mit weiteren
effektiven Praxis-Tools.
Fecal Occult Blood Screening before Cardiac Surgery
Authors: Takami Yoshiyuki , Maekawa Atsuo , Yamana Koji , Akita Kiyotoshi , Amano Kentaro , Sakurai Yusuke , Takagi Yasushi 
Published: March 2023

Abstract
Background Concerns of gastrointestinal (GI) bleeding after cardiac surgery are increasing with increased use of antiplatelets and anticoagulants. We investigated the roles of preoperative screening for fecal occult blood by fecal immunochemical test (FIT) widely used to detect GI bleeding and cancer.
Methods A retrospective review was done in 1,663 consecutive patients undergoing FIT before cardiac surgery between years 2012 and 2020. One or two rounds of FIT were performed 2 to 3 weeks before surgery, when antiplatelets and anticoagulants were not suspended yet.
Results Positive FIT (> 30 μg of hemoglobin/g of feces) was observed in 227 patients (13.7%). Preoperative risk factors for positive FIT included age > 70 years, anticoagulants, and chronic kidney disease. Of those with positive FIT, 180 patients (79%) received preoperative endoscopy, including gastroscopy (n = 139), colonoscopy (n = 9), and both (n = 32), with no findings of bleeding. The most common finding of gastroscopy was atrophic gastritis (36%) while early gastric cancer was detected in 2 patients. The most common finding of colonoscopy was colon polyps (42%) while colorectal cancer was detected in 5 patients. Of 180 FIT-positive patients receiving endoscopy, 8 (4.4%) underwent preoperative GI treatment, while postoperative GI events were documented in 28 (15.6%). Of 1,436 with negative FIT, 21 (1.5%) presented GI complications after surgery.
Conclusion Preoperative FIT, which is influenced by anticoagulant use, has little impacts on identification of GI bleeding sites. However, it may be useful to detect GI malignant lesions, potentially impacting operative risks, surgical strategies, and postoperative management.
Silver-Catalyzed Synthesis of Nitriles from Carboxylic Acids and Cyanamides
Authors: Zhang Jing , Li Mingsheng , Zi Lingjian , Chen Xinqaing 
Published: March 2023

AbstractA concise and practical silver-catalyzed nitrogen-atom-transfer protocol was developed to access versatile nitriles from ubiquitous carboxylic acids with N-cyano-N-phenyl-p-toluenesulfonamide. This protocol complements the established carboxylic acids-to-nitriles conversion methods, which suffer from laborious steps, high temperatures (≥200 °C), or limited substrate scopes. This approach operates broadly across diverse aryl, alkenyl, and primary-, secondary-, or tertiary-alkyl carboxylic acids.
Green Stereoselective Synthesis and In Silico Anticancer Evaluation of Tetrahydro-β-carboline-Derived Spiro Heterocycles
Authors: Deepthi Ani , Mohan Maneesh , Eldhose Susan P. , Sudheendranath Athul , G. Jayasree E. 
Published: March 2023

AbstractA green stereoselective synthesis of spiroheterocycles incorporating a spirooxindole and a 1,2,3,4-tetrahydro-β-carboline (THβC) are demonstrated here by the one-pot, three-component reaction of THβC, isatins, and chalcones. Operational simplicity and chromatography-free isolation are the highlights of the reaction which resulted in densely substituted spiroheterocycles with four-contiguous stereocenters in excellent yields. The activity of the compounds as anticancer agents was studied in silico against MDM2 and PLK1 target proteins and they show excellent binding interactions compared to reference drugs.
Impact of pharmacogenetics on aspirin resistance: a systematic review
Authors: Silva Gustavo Figueiredo da , Lopes Bruno Mattei , Moser Vinicius , Ferreira Leslie Ecker 
Published: March 2023

AbstractBackground Pharmacogenetics promises better control of diseases such as cardiovascular disease (CVD). Acetylsalicylic acid, aspirin, prevents the formation of an activating agent of platelet aggregation and vasoconstriction, and it is used to prevent CVD. Nevertheless, patients may have treatment failure due to genetic variants that modify the metabolism of the drug causing aspirin resistance (AR).Objectives To realize a systematic literature review to determine the impact of genetic variants on AR.Methods Articles published in the MEDLINE/PubMed, Cochrane, Scopus, LILACS, and SCIELO databases were systematically screened. A total of 290 articles were identified and 269 articles were excluded because they did not comply with the previously established inclusion criteria. A total of 20 case-control studies and 1 cohort was included.Results The genetic variants rs1126643 (ITGA2), rs3842787 (PTGS1), rs20417 (PTGS2), and rs5918 (ITGB3) were the most studied. As for relevance, of the 64 genetic variants evaluated by the articles, 14 had statistical significance (p < 0.05; 95% confidence interval [CI]) in at least one article. Among them, the following have had unanimous results: rs1371097 (P2RY1), rs1045642 (MDR1), rs1051931 and rs7756935 (PLA2G7), rs2071746 (HO1), rs1131882 and rs4523 (TBXA2R), rs434473 (ALOX12), rs9315042 (ALOX5AP), and rs662 (PON1), while these differ in real interference in AR: rs5918 (ITGB3), rs2243093 (GP1BA), rs1330344 (PTGS1), and rs20417 (PTGS2). As study limitations, we highlight the nonuniform methodologies of the analyzed articles and population differences.Conclusion It is noteworthy that pharmacogenetics is an expanding area. Therefore, further studies are needed to better understand the association between genetic variants and AR.
The clinical-radiological paradox in multiple sclerosis: myth or truth?
Authors: Hartmann Ana , Noro Fabio , Bahia Paulo Roberto Valle , Fontes-Dantas Fabricia Lima , Andreiuolo Rodrigo Ferrone , Lopes Fernanda Cristina Rueda , Pereira Valeria Coelho Santa Rita , Coutinho Renan Amaral , Araujo Amanda Dutra de , Marchiori Edson , Alves-Leon Soniza Vieira 
Published: March 2023

Abstract
Background Multiple sclerosis (MS) is an inflammatory, degenerative, demyelinating disease that ranges from benign to rapidly progressive forms. A striking characteristic of the disease is the clinical-radiological paradox.
Objectives The present study was conducted to determine whether, in our cohort, the clinical-radiological paradox exists and whether lesion location is related to clinical disability in patients with MS.
Methods Retrospective data from 95 patients with MS (60 women and 35 men) treated at a single center were examined. One head-and-spine magnetic resonance imaging (MRI) examination from each patient was selected randomly, and two independent observers calculated lesion loads (LLs) on T2/fluid attenuation inversion recovery sequences manually, considering the whole brain and four separate regions (periventricular, juxtacortical, posterior fossa, and spinal cord). The LLs were compared with the degree of disability, measured by the Kurtzke Expanded Disability Status Scale (EDSS), at the time of MRI examination in the whole cohort and in patients with relapsing-remitting (RR), primarily progressive, and secondarily progressive MS.
Results High LLs correlated with high EDSS scores in the whole cohort (r = 0.34; p < 0.01) and in the RRMS group (r = 0.27; p = 0.02). The EDSS score correlated with high regional LLs in the posterior fossa (r = 0.31; p = 0.002) and spinal cord (r = 0.35; p = 0.001).
Conclusions Our results indicate that the clinical-radiological paradox is a myth and support the logical connection between lesion location and neurological repercussion.