bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitating person-centered patient participation in kidney care—a process evaluation of a quasi-experimental study incorporating a tool and training of local implementation teams
Authors: Årestedt Liselott , Uhlin Fredrik , Eldh Ann Catrine 
Published: August 2023

Abstract

Background.
The transfer of innovations into healthcare is laden with challenges. Although healthcare professionals are expected to adopt and fulfil new policies, a more person-centered healthcare, with conditions allowing preference-based patient participation is anticipated.
Methods.
The aim of the study was to evaluate two implementation strategies for person-centered patient participation in kidney care, including dissemination of a clinical tool, and training and support of internal facilitators. Nine Swedish kidney care units participated in the study (August 2019–September 2021), strategically organized into: a control group (three sites, no support); a standard dissemination group (three sites, with a tool for patient participation and guidance disseminated to the site managers); and an implementation group (three sites, with the tool and guidance disseminated as above, plus a six-month support program for designated internal facilitators). This process evaluation was comprised of repeat interviews with managers (n = 10), internal facilitators (n = 5), recordings, and notes from the interventions, and Alberta Context Tool survey data (n = 78). Hybrid analyses comprised mixed methods: descriptive and comparative statistics, and qualitative descriptive analysis.
Results.
None of the control group sites addressed patient participation. While the standard dissemination sites’ managers received and appreciated the tool and the accompanying guidance package, they made no attempts to make further use of it. In the facilitated implementation group, five internal facilitators from three sites engaged in the support program. They welcomed the opportunity to learn about preference-based patient participation, and about implementation, including potentially enhanced opportunities for preference-based patient participation via the tool. Each site’s facilitators developed a separate strategy for the dissemination of the tool: the tool was used with a few patients in each site, and only some staff were involved. Although noting a general interest in improving patient participation, the internal facilitators described limited local support. Rather, they suggested a longer support program and more local backing and engagement.
Conclusions.
Facilitating person-centered patient participation is complex, given the need to address attitudes, beliefs, and behaviors. This study indicates slow uptake and change, and more efficient strategies are needed to ensure the fundamentals of care remain accessible to all.
WITHDRAWN: In vivo analgesic and anti-inflammatory efficacy of new imidazole (1, 3-diaza-2, 4-cyclopentadiene) analogues synthesised from Schiff base, as well as their characterization
Authors: Muheyuddeen Gulam , Khan Mohd Yaqub , Ahmad Tanzeem , Srivast Shriyansh , Verma Stuti 
Published: August 2023

Abstract
By reacting substituted amine and substituted benzaldehyde in an equal amount with glacial CH3COOH, an array of 1, 3-diaza-2, 4-cyclopentadiene derivatives (2a-2h) were produced in a large yield and excellent quality. It serves as a catalyst to produce substituted Schiff's base (intermediate). In order to create the intermediate (base) Schiff, ammonium acetate and benzil were further reacted with ethanol. "Mass spectrometry", "FT-IR", "1H NMR", "13C NMR", and elemental analysis were used to describe each of these compounds. In mice along with rats with carrageenan-induced paw oedema, the spontaneously generated analogues have been investigated as painkiller and soothing properties. Ingredients (2g) shown strong analgesia (89% at 100 mg/kg b.w.) and (2a, 2b) soothing (100% at 100 mg/kg b.w.) activity in comparison to the widely used medication diclofenac salt (100% at 50 mg/kg b.w.). The other substances had effective analgesia and soothing properties.
Immune Checkpoint Inhibitor without Pemetrexed for First-line Maintenance Therapy in Advanced Lung Adenocarcinoma: A real-world retrospective study
Authors: Gao Ming , Yang Wenyu , Wang Ting , Jing Fangfang , Zhang Fan , Tao Haitao , Ma Junxun , Hu Yi , Wang Lijie 
Published: August 2023

Abstract
Objective
To explore the efficacy and safety of immune checkpoint inhibitor (ICI) without pemetrexed as first-line maintenance therapy in driver-gene negative advanced lung adenocarcinoma.
Methods
A retrospective analysis was performed on patients with advanced lung adenocarcinoma treated with chemotherapy combined with ICI at the PLA General Hospital from January 2019 to June 2022. Clinical data of the patients were collected and followed up. SPSS (version 26.0) was used to analyze the clinical characteristics and survival of the patients.
Results
A total of 30 patients with ICI maintenance therapy and 39 patients of pemetrexed combined with ICI maintenance were included in this study. The median follow-up time was 23.2 months. PFS of ICI monotherapy maintenance group and pemetrexed combined ICI (P + ICI) maintenance group were 15.8 months (95%CI 7.6–23.9) and 22.6 months (95%CI 8.9–36.3). There was no statistical difference between the two groups (P = 0.42), and the median OS of both groups was not reached. ORR of ICI group was 60.0% (95%CI 42.5–77.5) and that of P + ICI group was 69.2% (95%CI 54.7 ~ 83.7). The incidence of treatment-related adverse reactions (TRAEs) was 90.0% and 92.3%, and the incidence of ≥ 3 grade events was 23.3% and 23.1%. No grade 5 adverse reactions occurred.
Conclusion
The maintenance treatment of ICI shown good therapeutic efficacy and controllable adverse events, which can be used as the first-line maintenance therapy for patients with driver-gene negative advanced lung adenocarcinoma.
Vault changes in eyes with a vertically implanted implantable collamer lens
Authors: Ouchi Masayuki 
Published: August 2023

Abstract
This prospective consecutive case series examined the postoperative and preoperative predicted vaults during vertical fixation of an implantable collamer lens (ICL). This study assessed 180 right eyes of 180 patients with ICL implants for myopic astigmatism. For the 90 eyes of 90 patients who underwent horizontal fixation (horizontal group) and 90 eyes of 90 patients who underwent vertical fixation (vertical group), biometrics by three-dimensional tomography of the anterior segment optical coherence tomography (A-OCT) was performed before surgery, and 2 h (2h), 1 day (1d), 1 week (1w), and 1 month after surgery (1m). Anterior chamber depth and postoperative vault were compared between the two groups. The difference between the preoperative predicted vault calculated using the KS formula installed in the A-OCT and the postoperative actual measured value was examined. The anterior chamber depth did not change at 2h, 1d, 1w, and 1m in both groups, and there was no significant difference from the preoperative values. Postoperative vault values were significantly lower in the vertical group than in the horizontal group over time. The difference between the vault measured 1m after surgery and the preoperative predicted value was significantly larger in the vertical group than in the horizontal group. Vertical fixation of the ICL reduced the vault by > 100 µm compared with horizontal fixation, which was different from the A-OCT preoperative predicted value
Timely surgical treatment of fallopian tubal pregnancy and interstitial pregnancy have no differential effect on intrauterine pregnancies after in vitro fertilization-embryo transfer
Authors: Zheng Mingxiang , Peng Yangqin , Cai Pei , He qingwen , Fei Gong , Hui Chen , Mao yuyao , Li Xihong , ouyang Yan 
Published: August 2023

Abstract

Background
Due to the specific nature of interstitial pregnancy (IP), there are significant risks to both the mother and the foetus in women with a heterotopic interstitial pregnancy. IP alone has been analysed as a site-specific ectopic preganncy in previous studies, however, according to the latest European Society of Human Reproduction and Embryology criteria, IP is classified as tubal pregnancy. If IP can be classified as tubal pregnancy, it means that there is no difference in the effects of these two on IUPs. Under the premise of timely surgery, disposing of IPs and tubal pregnancy (excluding IPs) should also have no differential effect on IUPs.
Methods
HP-tube and HIP patients seen at our hospital from January 2005 to December 2020 were included. All included patients were diagnosed by transvaginal sonography (TVS), and EPs were confirmed by surgery and pathological analysis. The IUP outcomes after surgical treatment of the EPs were compared between the HP-tube group (n = 464) and the HIP group (n = 206).
Results
Regarding IUPs, there was no significant difference between the HP-tube group and the HIP group in postoperative miscarriage (6.9% vs. 6.8%, odds ratio (OR) = 1.859, 95% confidence interval (CI) (0.807–4.279)), early spontaneous miscarriage (19.61% vs. 18. 93%, OR = 0.788, 95% CI (0.495–1.255), p = 0.316), and late miscarriage rates (0.43% vs. 0.49%, OR = 0.823, 95% CI (0.070–9.661), p = 0.877). There was no significant difference between the two groups in preterm birth (7.33% vs. 6.80%, OR = 1.044, 95% CI (0.509–2.139), p = 0.907), live birth (73.92% vs. 74.27%, OR = 1.010, 95% CI (0.665–1.534), p = 0.964), or perinatal mortality rates (1.51% vs. 0.49%, OR = 1.949, 95% CI (0.225–16.904), p = 0.545).
Conclusions
After early diagnosis and treatment of EPs, heterotopic fallopian tubal pregnancy and heterotopic interstitial pregnancy could achieve comparatively similar outcomes.
Enhanced elimination of chromium (VI) ions from wastewater with silica-mixed magnetic nanomaterial: Isotherm and kinetic studies
Authors: Ramesh B. , Deivayanai V.C. , Yaashikaa P.R. , Saravanan A , Jayasree R. , Amrutha R. 
Published: August 2023

Abstract
Disposing industrial wastewater and by-products from numerous segments has recently increased its demands in the ecological, methodological, economic, technological, and community spheres where the dispersed water isn’t treated before release. Rice husk is a waste agro field product from rice milling, an abundant source of silica and many other minerals. Rice husk ash is generated by combustion and deep burning out techniques at 600℃. To make 100% pure silica xerogels from RHA, a process involving alkaline separation accompanied by precipitation with acid was performed. Silica-coated Fe3O4 magnetic nanoparticles were produced via microwave practice and used for the complete elimination of Cr(IV) ions from water samples that is lab prepared solutions. The synthesized magnetic nanoparticles were characterized using Scanning electron microscopy (SEM) showing the structure of formed particles, X-ray diffraction (XRD) owns amorphous nature, Energy-dispersive X-ray (EDX) spectroscopy showing peaks of silica 45.36%, Ferrous 49.07%, and oxides in traces. Fourier- transform infrared spectroscopy (FT-IR), Dynamic Light Scattering (DLS), and Zeta Potential. Uniquely the pH value, heat, exposure duration, and dosage all have an impact on the target metal ion has been studied using Atomic Absorption Spectroscopy (AAS) to obtain optimum conditions. Langmuir isotherm seems to be the very greatest fit with the R2 value of 0.9791 and the qm is 102.8 mg/g this study also has great curve fitting in the pseudo-first-order model that supports the top physical adsorption.
Students’ Approaches to Learning (SAL) and their Relations to Burnout among University Freshmen in Singapore
Authors: Kok Xiao-Feng Kenan , Puah Shermain , Pua Ching Yee , Devilly Oran Zane , Lim Sok Mui 
Published: August 2023

Abstract
Assessing students’ approaches to learning (SAL) is crucial for evaluating their critical thinking abilities and subject domain comprehension. A deep approach and organised studying have been linked to lower study-related burnout, while an unreflective approach is associated with elevated levels of burnout. Despite evidence of the SAL–burnout connection, limited research exists on the bidirectional relationship between the two constructs. This study aims to fill this research gap by analysing changes in SAL and burnout during the freshmen year and determining whether the reciprocal relationship between these constructs. Freshmen data was collected from two cohorts (Cohort 1, n = 261; Cohort, n = 216) at the beginning and end of their first year. Findings revealed increased overall burnout, exhaustion, cynicism, and inadequacy from T1 to T2 in both cohorts. Deep approach decreased across T1 and T2 in both cohorts, while organised studying decreased on Cohort 1 but remained unchanged in Cohort 2. Conversely, unreflective approach decreased in Cohort 1 but increased in Cohort 2. Bidirectionality between SAL and burnout was observed in both cohorts, indicating that higher unreflective approach could lead to increased cynicism, and vice versa. These findings highlight the importance of recognizing the interplay between unreflective approach and cynicism for interventions targeting reduction in unreflective approaches and emphasizes the need to consider the potential unintended consequences of heightening freshmen’s cynical attitudes towards studying when attempting to reduce unreflective approach.
Improved Early Violence Detection through Dynamic Graph Classification
Authors: Johnson Joseph , Giraud-Carrier Christophe 
Published: August 2023

Abstract
Early detection of intracountry outbreaks of violence or intercountry conflicts plays animportant role in geopolitics. Generally, it is based on the use of handcrafted countryfeatures (e.g., demographics, economics) that may serve as proxy to the event ofinterest. While such features matter, it is often their evolution over time both at thecountry level and among countries. As such, we propose to use a graph-basedapproach that allows us to capture static, structural and sequential measures. Usingwell-known data sets, we show how this approach outperforms both baseline andstate-of-the-art approaches.
Deubiquitinating enzyme USP44 suppresses hepatocellular carcinoma progression through inhibiting Hedgehog signaling and PDL1 expression
Authors: Xie Peiyi , Chen Sisi , Zhou Binghai , Wei Huang , Li Qing , Ye Yu , Kuang Xiuqing , Huang Huabin , Wang Wei 
Published: August 2023

Abstract
Hepatocellular carcinoma (HCC) is one of the deadliest malignancies in the world. Research into the key genes that maintain the malignant behavior of cancer cells is crucial for the treatment of HCC. Here, we identify ubiquitin‐specific peptidase 44 (USP44), a member of deubiquitinase family, as a novel regulator of HCC progression. The tumor suppressive function of USP44 was evaluated in a series of in vitro and in vivo experiments including using USP44 flox/flox mice and orthotopic xenograft models.Through Quantitative Proteomics examination, we demonstrated that USP44 inhibits HCC PDL1 expression through downregulating Hedgehog (Hh) signaling pathway. Mechanistically, we found USP44 directly interacts with Itch, an E3 ligase involved in Hh signaling, and promotes the deubiquitination and stabilization of Itch.These events result in the proteasomal degradationof Gli1 and subsequent inactivation of Hh signaling, which ultimately suppresses the PDL1 expression and progression of HCC. Furthermore, HCC tissue microarray was analyzed by immunohistochemistry to evaluate the pathological relevance of the USP44/Itch/Gli1/PDL1 axis. At last, Gli1 inhibitor GANT61 was found to act in synergy with anti-PDL1 therapy. Overall, USP44 can act as a suppressive gene in HCC by modulating Hh signaling and co-inhibition of Gli1 and PDL1 might be an effective novel combination strategy for treating HCC patients.
5-chloro-3-(2-(2,4-dinitrophenyl) hydrazono)indolin-2-one: synthesis, characterization, and biochemical and computational screening against SARS-CoV-2
Authors: Majoumo-Mbe Felicite , Sangbong Neba Abongwa , Tcho Alain Tadjong , Namba-Nzanguim Cyril T , Simoben Conrad V , Eni Donatus B , Isa Mustafa A , Cassel Joel , Salvino Joseph M , Montaner Luis J , Tietjen Ian , Ntie-Kang Fidele 
Published: August 2023

Abstract

2,4-dinitrophenylhydrazone of 5-chloroisatin (H2L) was synthesized and characterized by elemental and spectral (IR, electronic, Mass) analyses. The NMR spectrum of H2L indicated keto-enol tautomerism, with the keto form being more abundantin solution. H2L was found to selectively interfere with binding of the SARS-CoV-2 spike receptor binding domain (RBD) to the host angiotensin-converting enzyme 2 receptor with a 50% inhibitory concentration (IC50) of 0.26 μM, compared to an unrelated PD-1-PD-L1 ligand-receptor binding pair with an IC50 of 2.06 μM in vitro (Selectivity index = 7.9). Molecular docking studies revealed that the synthesized ligand preferentially binds within the ACE2 receptor binding site in a region distinct from where spike mutations in SARS-CoV-2 variants occur. Consistent with these models, H2L was able to disrupt ACE2 interactions with the RBDs from beta, delta, lambda, and omicron with similar activities. These studies indicate that H2L-derived compounds are potential inhibitor(s) of multiple SARS-CoV-2 variants of concern including those capable of circumventing vaccine and immune responses.
A Correlation of Functional Outcome Measures of Pelvis Fracture Following Operative Management, A Retrospective Case Series
Authors: Delizo Shiela Marie B. , Garin Isagani E. 
Published: August 2023

Abstract
Background
To evaluate the functional outcome of pelvis fracture after fixation using Majeed functional outcome score.
Methods
Patients from our institution, Baguio General Hospital and Medical Center, with pelvis fractures from 2019 to 2022 were retrospectively gathered and reviewed. All available data sources were exhausted, such as charts from the hospital records, patient census, and electronic medical records. The functional outcome of the surgical intervention was assessed using Majeed's functional outcome score.
Results
18 patients were included in the study (three females, 15 males; mean age of 41 years) with a range of follow-up of one to three years. We performed a functional assessment using Majeed's functional outcome score; the mean score was 72 points (range 22–100). An excellent clinical outcome was seen in 22%, a good result in 39%, a fair result in 11%, and a poor outcome in 17% treated with internal fixation. In contrast, those treated with external fixation had a fair outcome.
Conclusions
Surgical internal fixation for pelvic fractures may be better than external fixation. There were no noted advantages of doing early surgical procedures versus delayed surgery. Concomitant injuries such as nerve injury and multiply injured patients may contribute to a poor to fair functional outcome.
Anatomical considerations for nerve transfer in axillary nerve injury
Authors: Kim Soo-Jung , Bang Jong-Ho , Yang Hee-Jun , Moon Seong-Hwan , Choi Yun-Rak , Lee Hye-Yeon 
Published: August 2023

Abstract
This study investigated the anatomical details of the axillary and radial nerves in 50 upper limbs from 29 adult formalin-embalmed cadavers, and 10 fresh upper limbs. The focus was on understanding the course, division, and ramifications of these nerves to improve treatment of shoulder dysfunction caused by axillary nerve damage. The axillary nerve divided anteriorly and posteriorly before passing the quadrangular space in all specimens, with specific distances to the first ramifications. It was found that the deltoid muscle's clavicular and acromial parts were always innervated by the anterior division of the axillary nerve, whereas the spinous part was variably innervated. The longest and thickest branches of the radial nerve to the triceps muscles were identified, with no statistically significant differences in fiber numbers among triceps branches. The study concludes that nerve transfer to the anterior division of the axillary nerve can restore the deltoid muscle in about 86% of shoulders, and the teres minor muscle can be restored by nerve transfer to the posterior division. The medial head branch and long head branch were identified as the best donor options.
Protecting the Neural Networks against FGSM Attack Using Machine Unlearning
Authors: Jahanian Ali , Rastgarpour Maryam , Khorasani Amir Hossein 
Published: August 2023

Abstract
Machine learning is a powerful tool for building predictive models. However, it is vulnerable to adversarial attacks. Fast Gradient Sign Method (FGSM) attacks are a common type of adversarial attack that add small perturbations to input data in order to trick a model into misclassifying it. In response to these attacks, researchers have developed methods for "unlearning" these attacks, which involves retraining a model on the original data without the added perturbations. Machine unlearning is a technique that try to "forget" a specific data points from the training dataset, in order to improve the robustness of a machine learning model against adversarial attacks like FGSM. In this paper, we focus on applying unlearning techniques to the LeNet neural network, a popular architecture for image classification. We evaluate the efficacy of unlearning FGSM attacks on the LeNet network and find that it can significantly improve its robustness against these types of attacks.
Intracranial hemorrhage and additional anomalies detected on prenatal magnetic resonance imaging: a large, retrospective study in two tertiary medical institutions
Authors: Liu Xuefen , Lu Yuanyuan , W Tianping , Zhu Hao , Bai Yu , Zhang Guofu , Zhang He 
Published: August 2023

Abstract
Purpose
To clarify the prenatal magnetic resonance (MR) imaging characteristics of foetal intracranial haemorrhages (ICHs) in a large cohort and correlate them with birth outcomes.
Methods
We retrospectively reviewed MR images of foetuses with ICH on screening ultrasound (US) on picture archiving communication system (PACS) servers within a nearly five-year period from two medical tertiary centres. The indications, main abnormal findings and coexistent anomalies were recorded by two experienced radiologists with census readings.
Results
We recruited 81 cases (average gestational week, 28.0 ± 5.0 weeks) with prenatal MR imaging, including 71 singleton pregnancies and 10 monochromic twin pregnancies. Predominant coexistent anomalies were ventriculomegaly (35.8%), holoprosencephaly or porencephaly (13.6%) and enlarged posterior fossa/ or posterior fossa cyst (7%) in the lesion-based evaluation. The number of haemorrhagic lesions and the occurrence of the detected complications did not show a correlation with the size of the haematoma. The mass effect of ICH was more commonly observed in foetuses with a large for gestational age (GA) than in foetuses with a small for GA.
Conclusion
Prenatal MR imaging could better show ICH morphology and associated abnormal findings. As a complementary tool of US, MR imaging could help with prenatal counselling and treatment selection after birth.