bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-Effectiveness of Cell Salvage in Trauma Blood Transfusions
Authors: Beeton George , Zagales Israel , Ngatuvai Micah , Atoa Andrew , Wajeeh Hassaan , Hoops Heather , Smith Chadwick P. , Elkbuli Adel 
Published: May 2023

Introduction Despite the increasing amount of evidence supporting its use, cell salvage (CS) remains an underutilized resource in operative trauma care in many hospitals. We aim to evaluate the utilization of CS in adult trauma patients and associated outcomes to provide evidence-based recommendations. Methods A systematic review was conducted using PubMed, Google Scholar, and CINAHL. Articles evaluating clinical outcomes and the cost-effectiveness of trauma patients utilizing CS were included. The primary study outcome was mortality rates. The secondary outcomes included complication rates (sepsis and infection) and ICU-LOS. The tertiary outcome was the cost-effectiveness of CS. Results This systematic review included 9 studies that accounted for a total of 1119 patients that received both CS and allogeneic transfusion (n = 519), vs allogeneic blood transfusions only (n = 601). In-hospital mortality rates ranged from 13% to 67% in patients where CS was used vs 6%-65% in those receiving allogeneic transfusions only; however, these findings were not significantly different ( P = .21-.56). Similarly, no significant differences were found between sepsis and infection rates or ICU-LOS in those patients where CS usage was compared to allogeneic transfusions alone. Of the 4 studies that provided comparisons on cost, 3 found the use of CS to be significantly more cost-effective. Conclusions Cell salvage can be used as an effective method of blood transfusion for trauma patients without compromising patient outcomes, in addition to its possible cost advantages. Future studies are needed to further investigate the long-term effects of cell salvage utilization in trauma patients.
Sub-anesthetic doses of ketamine increase single cell entrainment in the rat auditory cortex during auditory steady-state response
Authors: Munch Anders Sonne , Amat-Foraster Maria , Agerskov Claus , Bastlund Jesper Frank , Herrik Kjartan Frisch , Richter Ulrike 
Published: May 2023

Background: Understanding the effects of the N-methyl-D-aspartate receptor (NMDA-R) antagonist ketamine on brain function is of considerable interest due to the discovery of its fast-acting antidepressant properties. It is well known that gamma oscillations are increased when ketamine is administered to rodents and humans, and increases in the auditory steady-state response (ASSR) have also been observed. Aims: To elucidate the cellular substrate of the increase in network activity and synchrony observed by sub-anesthetic doses of ketamine, the aim was to investigate spike timing and regularity and determine how this is affected by the animal’s motor state. Methods: Single unit activity and local field potentials from the auditory cortex of awake, freely moving rats were recorded with microelectrode arrays during an ASSR paradigm. Results: Ketamine administration yielded a significant increase in ASSR power and phase locking, both significantly modulated by motor activity. Before drug administration, putative fast-spiking interneurons (FSIs) were significantly more entrained to the stimulus than putative pyramidal neurons (PYRs). The degree of entrainment significantly increased at lower doses of ketamine (3 and 10 mg/kg for FSIs, 10 mg/kg for PYRs). At the highest dose (30 mg/kg), a strong increase in tonic firing of PYRs was observed. Conclusions: These findings suggest an involvement of FSIs in the increased network synchrony and provide a possible cellular explanation for the well-documented effects of ketamine-induced increase in power and synchronicity during ASSR. The results support the importance to evaluate different motor states separately for more translational preclinical research.
Characterizing opioid use in a Dutch cohort with migraine
Authors: van Welie Rein F , van Welie Floor C , de Vries Lentsch Simone , Dahan Albert , van Velzen Monique , Terwindt Gisela M 
Published: May 2023

BackgroundThere is lack of data on opioid (over)use for migraine in Europe.MethodsWe performed a cross-sectional study in a large Dutch cohort using a web-based questionnaire to assess opioid use in individuals with migraine. Primary outcome was to assess opioid use for the treatment of migraine attacks. As secondary outcomes we specified use of opioids (duration of use, type of opioids, prescriber) and compared between persons with episodic migraine versus chronic migraine. Descriptive statistics, unpaired T-tests, Chi-square and Mann-Whitney U tests were used.ResultsIn total n = 3712 patients participated, 13% ever used opioids for headache. In opioid users, 27% did this for >1 month, and 11% for >1 year, and 2% without prescription. The majority of prescribing physicians were general practitioners (46%), followed by neurologists (35%), other specialists (9%), or emergency room doctors (8%). Opioids were used as acute treatment in 63%, in 16% as preventive treatment, and in 21% for both indications. Chronic migraine patients reported more opioid use compared with episodic migraine (22% versus 12%, p < 0.001), with also more prolonged use (>1 month: 34% chronic migraine versus 24% episodic migraine, p < 0.003).ConclusionOpioid use is more frequent and prolonged in chronic migraine patients. Further education for both doctors and migraine subjects and providing multimodal pain management strategies are needed to reduce opioid use in persons with migraine.
‘To see or not to see, that is the question’ – A commentary on patient Selection for the RANZCP psychotherapy written case
Authors: Yeates Steven 
Published: May 2023

Objective This paper aims to redress the shortage of published guidance for registrars on selecting suitable patients for the RANZCP Psychotherapy Written Case Summative Assessment. Conclusions This article offers a common-sense approach to patient selection using psychiatric nomenclature and organises patients into proposed categories of likely suitable, possibly suitable, and unsuitable. A flowchart tool is offered for screening patients stressing a Global Assessment of Function (GAF) and the premorbid capacity to adhere to social frames such as school, university, employment, and relationships.
Changes in Retail Tobacco Product Availability Following a Chicago City Ordinance Restricting Sales of Menthol and Other Flavored Tobacco Products Near Schools
Authors: Slater Sandy , Pugach Oksana , Rogers Todd , Barker Dianne C. , Ross Ashley , Tworek Cindy , Ridgeway William , Dart Leah , Engstrom Martha C. 
Published: May 2023

Background In April 2016, the City of Chicago implemented an ordinance restricting the sale of all flavored (including menthol) tobacco products (FTPs), including electronic cigarettes, at retailers located within 500 feet of any public, private, or alternative elementary, middle (“primary”), or high (“secondary”) school. We examined changes in retail availability of FTPs from before to after policy implementation among policy-affected retailers compared with retailers not subject to the policy. Method Observational data were collected in June to September 2015 (Wave 1; pre-policy) and November to December 2016 (Wave 2; post-policy) from a panel of 194 randomly selected policy-area stores (located within 500 feet of a school), and a panel of 199 randomly selected comparison-area stores (located more than 500 feet from a school). Using generalized estimation equation regression, we assessed differences in FTP availability changes across study areas. Results We observed a statistically significant policy effect on FTP availability (Area × Wave interaction, p < .05); however, more than half of policy-area retailers continued to display at least one FTP after policy implementation (87.11% at Wave 1, 57.73% at Wave 2, p < .05). Similar reductions were seen for the availability of flavored cigarillos/little cigars and menthol cigarettes, while policy effects varied across store types. Discussion FTP availability reductions appear to be associated with policy implementation, but FTPs remained readily available at retailers subject to the policy. This study contributes to the evidence base indicating that policies with exclusions or exemptions for certain flavors, products, store types, or retailer locations have a limited effect on retail availability of FTPs.
Current Utilization of Electron Microscopy in the Pediatric Pathology Setting: A Survey by the SPP Practice Committee
Authors: Warren Mikako , Reed Robyn C. , Prasad Vinay , Rajaram Veena , Roberts Drucilla , Kreiger Portia A. , Darrisaw Lora , Besmer Sherri , Church Alanna J. , Keisling Matthew , Craver Randall D. , Cole Bonnie L. , Robers James , Lopez-Terrada Dolores 
Published: May 2023

Background: Electron microscopy (EM), once an important component in diagnosing pediatric diseases, has experienced a decline in its use. To assess the impact of this, pediatric pathology practices were surveyed regarding EM services. Methods: The Society of Pediatric Pathology Practice Committee surveyed 113 society members from 74 hospitals. Settings included 36 academic tertiary, 32 free-standing children’s, and 6 community hospitals. Results: Over 60% maintained in-house EM services and had more than 2 pathologists interpreting EM while reporting a shortage of EM technologists. Freestanding children’s hospitals had the most specimens (100-200 per year) and more diverse specimen types. Hospitals with fewer than 50 yearly specimens often used reference laboratories. Seventeen had terminated all in-house EM services. Challenges included decreasing caseloads due to alternative diagnostic methods, high operating costs, and shortages of EM technologists and EM-proficient pathologists. Kidney, liver, cilia, heart, and muscle biopsies most often required EM. Lung/bronchoalveolar lavage, tumor, skin, gastrointestinal, nerve, platelet, and autopsy samples less commonly needed EM. Conclusions: The survey revealed challenges in maintaining EM services but demonstrated its sustained value in pediatric pathology. Pediatric pathologists may need to address the centralization of services and training to preserve EM diagnostic proficiency among pathologists who perform ultrastructural interpretations.
Effect of intralenticular dexamethasone implant: A case report
Authors: Carnevali Adriano , Taloni Andrea , Gatti Valentina , Lamonica Luca , Oliverio Flavia , Randazzo Giorgio , Scorcia Vincenzo 
Published: May 2023

Introduction Intravitreal dexamethasone (DEX) implant is indicated for the treatment of macular oedema due to diabetic retinopathy, retinal vein occlusion and uveitis. The most common complications are cataract and elevated intraocular pressure (IOP). Accidental injection of DEX implant into the lens is a rare complication and only few papers presented it. Case Presentation A 40-year-old man was treated with DEX implant for diabetic macular oedema in both eyes. At 1 week follow-up visit, slit lamp examination showed the DEX implant was located in the crystalline lens of the right eye (RE) without any sign of inflammation, cataract or elevated IOP, so we decided to plan a normal follow-up schedule. Macular oedema relapsed 5 months after the injection in the left eye (LE), whereas the RE did not show any sing of intraretinal or subretinal fluid. Six months after DEX implantation an uneventful phacoemulsification and intraocular lens placement were performed in the RE because of IOP elevation. Conclusions The therapeutic effect of DEX implant can be maintained for a longer period of time than intravitreal implant, determining complete reabsorption of macular oedema. Intralenticular implant can be maintained inside the lens until either IOP increases, cataract progresses, or other complications occur.
The association between leisure engagement and loneliness before and during the COVID-19 pandemic: A Nordic population-based study
Authors: Nyqvist Fredrica , Nilsson Ingeborg , Näsman Marina , Olofsson Birgitta 
Published: May 2023

Aim: The main aim of this study was to examine leisure engagement and loneliness among older adults before and during the COVID-19 pandemic by analysing population-based data from western Finland and northern Sweden. Methods: The data originated from the Gerontological Regional Database (GERDA) postal questionnaire study conducted in 2016 ( n=7996) and 2021 ( n=8148) among older adults aged 65, 70, 75, 80 and 85 years. Associations between loneliness and leisure engagement were analysed using logistic regression. Results: In total, 10% and 9% of the older adults reported loneliness in 2016 and 2021, respectively. The results showed that a lack of engagement in socialising and pleasure was independently associated with loneliness in both study years, while a lack of engagement in cultural activities was associated with loneliness in 2016 only. In 2021, the likelihood of experiencing loneliness was higher in the Finnish region than in the Swedish region. In addition, those reporting a decrease in hobby and socialising leisure activities due to the COVID-19 pandemic were more likely to report loneliness. Conclusions: Most leisure activities decreased during the pandemic, suggesting an increase in social isolation. However, this did not reflect an increase in loneliness in the studied regions. The evidence suggests that leisure engagement, especially socialising activities, continued to be important for well-being among older adults during the pandemic. Further, loneliness was affected by contextual factors as well as individual-level characteristics. Thus, according to the measures reported here, the pandemic seemed to have a slightly weakened well-being impact in Finland.
COVID-19 conspiracy beliefs and vaccinations: A conceptual replication study in Turkey
Authors: Pivetti Monica , Paleari Francesca-Giorgia , Ertan Irem , Di Battista Silvia , Ulukök Esra 
Published: May 2023

Pivetti et al. (2021a; 2021b) examined links between COVID-related conspiracy beliefs and acceptance of vaccinations in Italy and Finland in 2020. They found that moral purity negatively predicted confidence in science, whereas political orientation predicted COVID-related conspiracy beliefs. Confidence in science, general conspiracy beliefs, and COVID-related conspiracy beliefs were found to negatively predict support for governmental restrictions and attitudes towards vaccines, and positively predict perceptions of informational contamination. Finally, attitudes towards vaccines in general strongly predicted attitudes towards the COVID-19 vaccine. The current research seeks to replicate these findings conceptually on a predominately Muslim sample (N  =  570, M age  =  26.69, 69.8% females) in Turkey in 2021, when the COVID vaccines were widely available. Measures of religiosity and left, center, and right political orientations were added to the original instrument. Hypothesized serial mediational models were tested using structural equation modelling. Results revealed that left and center political orientations positively predicted COVID-related conspiracy beliefs and confidence in science. Religiosity was negatively related to confidence in science. Confidence in science and COVID-related conspiracy beliefs predicted general attitudes toward vaccines. Conspiracy beliefs predicted COVID-related conspiracy beliefs, which in turn negatively predicted support for government restrictions and positively predicted distrust in mainstream media. Attitudes towards vaccines were strongly and positively related to attitudes toward COVID-19 vaccines. [This paper was added to the Special Issue on “Conspiracy Theories about Infectious Diseases” in a post-hoc manner. Online publishing allows the addition of new papers to a published special issue, thereby permitting a special issue to grow.]
Tobacco Knowledge, Attitudes, and Services Among Latino/a Community Health Workers
Authors: Villacis Alvarez Enrique , Nicholson Lian , Villamar Dario , Huard Clarissa , Veluz-Wilkins Anna , Tan Marcia 
Published: May 2023

Background: Tobacco-related illnesses are among the leading preventable causes of death for Latinos/as in the United States. Latino/a groups are less likely to receive advice to quit from health professionals or use tobacco cessation strategies. The position of community health workers (CHWs) warrants further attention to address tobacco-related disparities in Latino/a communities. The objective of this study was to describe CHWs’ roles to inform future smoking cessation training to ensure relevance and accessibility. Methods: A needs assessment survey, including a 10-item tobacco knowledge questionnaire, was conducted with 29 Latino/a CHWs serving Latino/a communities in a metropolitan area to assess their roles, tobacco related services, attitudes, and knowledge. Results: All CHWs were Spanish-speaking and mainly employed part time (55%) in community organizations (67%). They offered various services, primarily health education. Most of the CHWs (58.6%) assessed and discussed tobacco use, yet half (51.7%) reported low confidence in this area. Some CHWs (41%) expressed that their clients/patients would use evidence-based nicotine replacement therapies as a smoking cessation treatment if offered and identified “Financial Cost” (31%) as a deterrent of use. CHWs’ score on a tobacco knowledge questionnaire indicated low knowledge in areas related to tobacco (4.03 out of 10; SD = 1.92). Conclusions: CHWs reported low tobacco related knowledge and confidence, and would benefit from tailored tobacco cessation training to decrease tobacco cessation disparities.
Enlightened Participation: SME Perspectives about Net Zero on Social Media Using the Action Case Approach
Authors: Hardey Mariann , Ahmed Wasim , Fenton Alex , Koral Chris 
Published: May 2023

Aims/Objectives: This study aims to examine a linked future for a Net Zero global economy. Such a future is examined through network-driven change and informed by co-action and shared business management practices. Methodology used in the study: We employ an action case (AC) approach to understand the impact of national and worldwide Net Zero policy for small and medium-sized enterprises (SMEs). We drew upon a qualitative survey with SMEs alongside a social network analysis (SNA) of Twitter data. Findings: We discovered a substantial predictive effect of policy support in the SME social media material regarding Net Zero attitudes. Our findings indicate that reinforcing messages on policy support and assisting enterprises in adopting the new objectives may considerably enhance Net Zero accountability and serve as the foundation for an intervention strategy in policy-focused programmes for SMEs.
The RISE study protocol: resilience impacted by positive stressful events for people with cystic fibrosis
Authors: van der Heijden Els , van den Bor Rutger M. , van der Ent Cornelis K. , Nijhof Sanne L. , van der Laan Sabine E.I. 
Published: May 2023

IntroductionFor people with cystic fibrosis (CF), gaining access to elexacaftor/tezacaftor/ivacaftor (ETI) therapy, a new modulator drug combination, is perceived as a positive life event. ETI leads to a strong improvement of disease symptoms. However, some people with CF experience a deterioration in mental wellbeing after starting ETI therapy. The primary objective of this study is to investigate if and in which direction mental wellbeing of people with CF changes after starting ETI therapy. Our secondary objectives include, among others, investigation of underlying biological and psychosocial factors associated with a change in mental wellbeing of people with CF after starting ETI therapy.Methods and analysisThe Resilience lmpacted by Positive Stressful Events (RISE) study is a single-arm, observational, prospective longitudinal cohort. It has a timeframe of 60 weeks: 12 weeks before, 12 weeks after, 24 weeks after and 48 weeks after the start of ETI therapy. The primary outcome is mental well-being, measured at each of these four time points. Patients aged ≥12 years at the University Medical Center Utrecht qualifying for ETI therapy based on their CF mutation are eligible. Data will be analysed using a covariance pattern model with a general variance covariance matrix.EthicsThe RISE study was classified by the institutional review board as exempt from the Medical Research Involving Human Subjects Act. Informed consent was obtained by both the children (12–16 years) and their caregivers, or only provided by the participants themselves when aged ≥16 years.
Mood disorder in idiopathic pulmonary fibrosis: response to pulmonary rehabilitation
Authors: Edwards George D. , Polgar Oliver , Patel Suhani , Barker Ruth E. , Walsh Jessica A. , Harvey Jennifer , Man William D-C. , Nolan Claire M. 
Published: May 2023

BackgroundPulmonary rehabilitation improves mood disorder in COPD, but there are limited data in idiopathic pulmonary fibrosis (IPF). The aims of this cohort study were to investigate whether pulmonary rehabilitation reduces mood disorder in IPF, and estimate the minimal important difference (MID) of the Hospital Anxiety and Depression Scale (HADS).MethodsHADS and core pulmonary rehabilitation outcomes were measured in 166 participants before and after an 8-week, in-person, outpatient pulmonary rehabilitation programme. Anchor- and distribution-based methods were used to calculate the MID of HADS-Anxiety (A) and HADS-Depression (D).ResultsSuggestive or probable anxiety and depression (HADS ≥8) were present in 35% and 37% of participants, respectively, at baseline, and this reduced significantly following pulmonary rehabilitation (post-pulmonary rehabilitation: HADS-A 23%, HADS-D 26%). Overall, there was a significant reduction in HADS-D (mean change −1.1, 95% CI −1.6– −0.5), but not HADS-A (−0.6, −1.3–0.15) with pulmonary rehabilitation. Subgroup analysis of those with HADS ≥8 revealed significant improvements in HADS domains (mean change: HADS-A −4.5, 95% CI −5.7– −3.4; median change: HADS-D −4.0, interquartile range −6.0– −1.0). The mean (range) MID estimates for HADS-A and HADS-D were −2 (−2.3– −1.7) and −1.2 (−1.9– −0.5), respectively.ConclusionIn people with IPF and suggestive or probable mood disorder, pulmonary rehabilitation reduces anxiety and depression.
Inhibition of tumor immune escape by blocking PD-1/PD-L1 engagement with dual-targeting molecularly imprinted polymer layer
Authors: Ji Wenwen , Zhang Bei , Sun Xuetong , Ma Lijuan , Zhang Xiangying , Qian Wenhui , Fu Wenjuan , Li Jianting , Zhu Dong 
Published: May 2023

AbstractBlocking the binding of PD-1/PD-L1 has become an effective strategy in inhibition of tumor immune escape. At present, it mainly depends on the employment of macromolecular antibodies, which target PD-1/PD-L1 protein through binding one of PD-1 or PD-L1 domains. In this study, we present a different strategy, an aptamer modified molecularly imprinted polymer layer (APD–PD-L1–MIPL), to break PD-1/PD-L1 binding for the inhibition of tumor immune escape. The APD–PD-L1–MIPL is prepared by a MIP layer on the surface of CaCO3 nanospheres using the peptide segment of the PD-L1 protein as a template. The subsequent removal of CaCO3 nanospheres core formats the MIP layer, to ensure high specifically matching capacity and short equilibrium time. A PD-L1 antagonistic DNA aptamer, is modified into the MIP layer to enhance recognition capacity, resulting in dual-targeting functionality. The APD–PD-L1–MIPL is able to bind PD-L1 and allow suppressing the engagement of PD-L1 with PD-1, inducing to block of the downstream signaling pathways and, therefore, restore T cell function and inhibition of cancer growth. The APD–PD-L1–MIPL can quantitatively detect the bound proteins and the LOD of APD–PD-L1–MIPL is 0.003 mg mL−1. This strategy enables provide a new idea for tumor immunotherapy.