bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Excavation of Nanoethosomes in Current Drug Delivery
Authors: Agrawal Aishwarya , Joshi Aalind , Bhattacharya Sankha 
Published: December 2022

Abstract:
In the current era, the Transdermal delivery of bioactive molecules has become an area of
research interest. The transdermal route of administration enables direct entry of bioactive molecules
into the systemic circulation with better and easy accessibility, bypassing the hepatic metabolism and
improving patient compliance. Permeation through the skin has always been a barrier. To overcome this
challenge, an efficient route by the vesicular system has been adopted so as to have better skin permeation
of the bioactive molecules. A novel vesicular and non-invasive drug delivery system called Nanoethosomes
was developed. Nanoethosomes are lipid-based vesicular carriers that are used for deeper
permeation of the bioactive agents into the skin. The main components of Nanoethosomes are Phospholipids,
water, and ethanol. High ethanol concentration in Nanoethosomes distinguishes them from other
nano-formulation and results in deeper permeation and smaller vesicular size. This review article gives
detailed information on the formulation techniques, and characterization parameters of nanoethosomes
along with the research work done by various researchers in the same field. The compiled manuscript
gives detailed elaboration about the various drugs used to treat different diseases which when incorporated
in nanoethosomes resulted in better permeability and enhanced bioavailability.
A Multidisciplinary and a Comprehensive Approach to Reducing Fragility
Fractures in Preterm Infants
Authors: Saif Saif Al , Maghoula Mohammad , Babiker Amir , Abanmi Mashael , Nichol Fiona , Al Enazi Modhi , Guevarra Elenor , Sehlie Faisal , Al Shaalan Hesham , Mughal Zulf 
Published: December 2022

Abstract:
With advances in neonatal care, bone fractures prior to discharge from the hospital in preterm infants receiving contemporary neonatal care, are rare. Nevertheless, such fractures do oc-cur in very low birth weight and extremely low birth weight infants who go on to develop metabolic bone disease of prematurity (MBDP), with or without secondary hyperparathyroidism. MBDP is a multifactorial disorder arising from the disruption of bone mass accrual due to premature birth, postnatal immobilisation, and loss of placental oestrogen resulting in bone loss, inadequate provi-sion of bone minerals from enteral and parenteral nutrition, and medications that leach out bone minerals from the skeleton. All of these factors lead to skeletal demineralisation and a decrease in bone strength and an increased risk of fractures of the long bones and ribs. Secondary hyperparathy-roidism resulting from phosphate supplements, or enteral/parenteral feeds with a calcium-to-phosphate ratio of < 1.3:1.0 leads to subperiosteal bone resorption, cortical thinning, and further skeletal weakening. Such fractures may occur from routine handling and procedures such as cannu-lation. Most fractures are asymptomatic and often come to light incidentally on radiographs per-formed for other indications. In 2015, we instituted a comprehensive and multidisciplinary Neonatal Bone Health Programme (NBHP), the purpose of which was to reduce fragility fractures in high-risk neonates, by optimising enteral and parenteral nutrition, including maintaining calcium-to-phosphate ratio ≥1.3:1, milligram to milligram, biochemical monitoring of MBDP, safe-handling of at-risk neonates, without compromising passive physiotherapy and skin-to-skin contact with par-ents. The at-risk infants in the programme had radiographs of the torso and limbs at 4 weeks and af-ter 8 weeks from enrolment into the program or before discharge. Following the introduction of the NBHP, the bone fracture incidence reduced from 12.5% to zero over an 18-month period.
The Role of Advanced Technologies against COVID-19: Prevention,
Detection, and Treatments
Authors: Hasanzadeh Elham , Rafati Adele , Tamijani Seyedeh Masoumeh Seyed Hosseini , Rafaiee Raheleh , Golchin Ali , Abasi Mozhgan 
Published: December 2022

Abstract:
Concurrent with the global outbreak of COVID-19, the race began among scientists to generate
effective therapeutics for the treatment of COVID-19. In this regard, advanced technology such as nanotechnology,
cell-based therapies, tissue engineering and regenerative medicine, nerve stimulation and
artificial intelligence (AI) are attractive because they can offer new solutions for the prevention, diagnosis
and treatment of COVID-19. Nanotechnology can design rapid and specific tests with high sensitivity for
detecting infection and synthases new drugs and vaccines based on nanomaterials to directly deliver the
intended antiviral agent to the desired site in the body and also provide new surfaces that do not allow
virus adhesion. Mesenchymal stem cells and exosomes secreted from them apply in regenerative medicine
and regulate inflammatory responses. Cell therapy and tissue engineering are combined to repair or
substitute damaged tissues or cells. Tissue engineering using biomaterials, cells, and signaling molecules
can develop new therapeutic and diagnostic platforms and help scientists fight viral diseases. Nerve stimulation
technology can augment body's natural ability to modulate the inflammatory response and inhibit
pro-inflammatory cytokines and consequently suppress cytokine storm. People can access free online
health counseling services through AI and it helps very fast for screening and diagnosis of COVID-19
patients. This study is aimed first to give brief information about COVID-19 and the epidemiology of the
disease. After that, we highlight important developments in the field of advanced technologies relevant to
the prevention, detection, and treatment of the current pandemic.
Under the magnifying glass: critical moments in virtual exchange
Authors: Háhn Judit , Radke Katarzyna , Dekker Ivonne 
Published: December 2022

Virtual Exchange (VE) is a form of experiential learning that relies heavily on learning-by-doing and reflection. The present study draws on visual data comprising students’ perceptions of critical learning incidents presented under an imaginary magnifying glass. To complete this project-closing reflective activity, the students had to describe a critical moment that they had experienced during VE and present it in a visual form. Data was collected longitudinally, in three projects (2019, 2020, and 2021) that followed the same pedagogical design and focused on the theme of tourism. The collaborating universities were from three countries: Poland, Finland, and the Netherlands. We used the methods of qualitative content analysis and social semiotic analysis to investigate the students’ reflections. The findings show that the most frequently expressed themes were related to participation in the first meeting, joint production, use of a foreign language, and adaptation to change. The study contributes to a better understanding of the role of multimodal reflection in VE.
Patient-Facing Clinical Decision Support for High Blood Pressure Control: Patient Survey
Authors: Dorr David , D'Autremont Chris , Richardson Joshua E , Bobo Michelle , Terndrup Christopher , Dunne M J , Cheng Anthony , Rope Robert 
Published: December 2022

Background
High blood pressure (HBP) affects nearly half of adults in the United States and is a major factor in heart attacks, strokes, kidney disease, and other morbidities. To reduce risk, guidelines for HBP contain more than 70 recommendations, including many related to patient behaviors, such as home monitoring and lifestyle changes. Thus, the patient’s role in controlling HBP is crucial. Patient-facing clinical decision support (CDS) tools may help patients adhere to evidence-based care, but customization is required.

Objective
Our objective was to understand how to adapt CDS to best engage patients in controlling HBP.

Methods
We conducted a mixed methods study with two phases: (1) survey-guided interviews with a limited cohort and (2) a nationwide web-based survey. Participation in each phase was limited to adults aged between 18 and 85 years who had been diagnosed with hypertension. The survey included general questions that assessed goal setting, treatment priorities, medication load, comorbid conditions, satisfaction with blood pressure (BP) management, and attitudes toward CDS, and also a series of questions regarding A/B preferences using paired information displays to assess perceived trustworthiness of potential CDS user interface options.

Results
We conducted 17 survey-guided interviews to gather patient needs from CDS, then analyzed results and created a second survey of 519 adults with clinically diagnosed HBP. A large majority of participants reported that BP control was a high priority (83%), had monitored BP at home (82%), and felt comfortable using technology (88%). Survey respondents found displays with more detailed recommendations more trustworthy (56%-77% of them preferred simpler displays), especially when incorporating social trust and priorities from providers and patients like them, but had no differences in action taken.

Conclusions
Respondents to the survey felt that CDS capabilities could help them with HBP control. The more detailed design options for BP display and recommendations messaging were considered the most trustworthy yet did not differentiate perceived actions.
PENGHEMATAN BIAYA PERSEDIAAN OBAT MENGGUNAKAN METODE HYBRID DI RSIA PERDANA MEDICA SURABAYA
Authors: Astri Widya Krisyunita  , Djunawan Achmad , Khoirul Umam  
Published: December 2022

Background: Based on drugs inventories data at pharmacy unit Perdana Medica Maternal and Child Hospital Surabaya in March 2020, 35 items of drugs and medical devices were expired and damaged. In addition, stock out caused an Rp11,295,500.00 profit loss (estimated). Based on these problems, research is needed to
find how much savings can be achieved in planning the procurement of drugs using the hybrid method.
Objective: Find out how much savings can be made by RSIA Perdana Medica in planning the procurement of drugs using the hybrid method.
Methods: This research is quantitative descriptive research. The ABC-VED method is used to classify drug inventories based on their use and investment levels. Inventory policy is searched using the hybrid method by comparing actual costs with expected total costs.
Result: Perdana Medica Maternal and Child Hospital could save Rp4,440,457.85 expenses based on the calculation results.
Conclusion: The hybrid method can be used as a new method in inventory planning at Perdana Medica Maternal and Child Hospital.
PERBAIKAN KUALITAS PELAYANAN DI RSUD R.A.A. TJOKRONEGORO PURWOREJO DENGAN METODE IPA, ZOT DAN PGCV
Authors: Haryanto Niko Dwi , Anas Alrasyid Putrawidya Buana  
Published: December 2022

Latar belakang : Perbaikan kualitas pelayanan bukan hanya diperlukan karena adanya kebutuhan masyarakat, melainkan adanya tingkat persaingan dengan rumah sakit lainnya, oleh karena itu pihak manajemen runah sakit harus bisa mengukur bagaimana kualitas pelayanan yang diberikan dan memperbaiki atribut-atribut apa saja yang perlu mendapatkan perbaikan nantinya.
Tujuan : Penelitian ini bertujuan untuk memetakan, mengukur toleransi, menentukan prioritas peringkat atribut dan mengusulkan upaya perbaikan kualitas pelayanan yang bisa dilakukan oleh pihak manajemen RSUD R.A.A Tjokronegoro.
Metode : Metode yang digunakan adalah analitik deskriptif dengan metode Importance Performance Analysis (IPA), Zone of Tolerance (ZOT), dan Potential Gain Customer Value (PGCV).
Hasil : Hasil penelitian pada 61 responden pasien rawat jalan dengan analisis IPA rumah sakit perlu melakukan penyesuaian waktu pelayanan, meningkatkan kesigapan pegawai, meningkatkan kepercayaan pasien, dan meningkatkan fasilitas fisik seperti tempat parkir. Dengan metode ZOT menghasilkan lima atribut yang tidak bisa ditoleransi yaitu waktu pelayanan, kesigapan pegawai, kecepatan penyelesaian administrasi, kepercayaan pasien kepada pegawai, dan pemahaman pegawai akan kebutuhan pasien. Berdasarkan perhitungan PGCV yang diolah dari perhitungan IPA didapat 5 atribut dengan prioritas perbaikan pegawai memahami kebutuhan pasien (3.26), pelayanan diberikan dengan waktu yang sesuai dan kesigapan pada pegawai rumah sakit (3.23), pegawai dapat dipercaya saat melakukan pekerjaanya (3.19), keterjangkauan biaya pelayanan (3.11) dan terakhir pegawai melayani dengan usaha terbaik (3.09).
Simpulan : Upaya yang bisa dilakukan oleh pihak dalam memperbaiki kualitas pelayanan terdiri mengembangkan rasa empati pegawai kepada pasien, melakukan kesesuaian waktu dalam pelayanan, menambahkan prosedur dan pengawasan terkait kesigapan pegawai dan melakukan seleksi yang ketat.
Flint products from a Globular Amphora culture grave in Stefankowice-Kolonia, Hrubieszów District, site 33 in the light of the latest considerations
Authors: Mączyński Piotr 
Published: December 2022

The aim of this article is to present considerations on the technological and functional aspects of flint tools produced by the community of the Globular Amphora culture. These reflections are based on discoveries made in a box grave from site No. 33 in Stefankowice-Kolonia (southeastern Poland). During the exploration of the funerary feature, a skeleton was found. It belonged to a man in the Maturus age. The body was accompanied by an abundant set of flint products composed of five blades and three axes (including one half-product). These artefacts were subjected to a technological analysis aimed at determining the techniques employed in the production of the blades and core tools.
The analysis was complemented with microscopic examination performed in order to determine the functions of the discovered products. As a result, it was stated that the grave had been furnished with a collection of blades and an axe half-product that probably had never been used. This was not the case for the other two axes. On one of them, there were patterns indicating that it had been used for a long time to process wood. The patterns found on the other one were the result of hafting only. This fact is interesting, since there are no traces of use damage on the cutting edge. It appears that this artefact was abraded (sharpened anew) before being deposited in the grave.
Lyssnandets pedagogik - ett trauma, en upplysning?
Authors: Lenz Taguchi Hillevi 
Published: December 2022

Den här artikelns syfte är att göra en postkvalitativ filosofisk analys av den mångfacetterade förståelsen och upptagandet av fenomenet en lyssnandets pedagogik. För att undersöka detta genomförs diffraktiva läsningar med inspiration från Donna Haraway och Karen Barad. Diffraktiva läsningar innebär i denna studie att ett antal texter läses genom varandra och genom forskarens egna erfarenheter och kunskaper om ett fenomen. Analysen visar att det är möjligt att förstå erfarenheten av en lyssnandets pedagogik i termer av såväl en upplysning – Sapere aude – knuten till en transcendental ontologi, som ett trauma – Parrhesia – knutet till en relationell ontologi. Erfarenheterna kan överlappa och uppträda hos samma individ. De varandeteoretiska villkoren blir avgörande för i vilken utsträckning en lyssnandets pedagogik kan praktiseras med större öppenhet mot förändring och en multiplicitet av olika teoretiska och didaktiska möjligheter i förhållande till det pedagogiska arbetet. Detta visar sig särskilt tydligt i praktiserandet av dekonstruktiva samtal kring pedagogisk dokumentation av den egna praktiken.
A Pedagogy of Listening – a trauma, an enlightenment?
The aim of this article is to make a postqualitative philosophical analysis of the multifacetted understanding and uptake of the phenomenon of a Pedagogy of Listening. In order to do so, I undertake diffractive readings with inspiration from Donna Haraway and Karen Barad. In this study, diffractive readings mean reading chosen texts into each other and through the researcher’s own experiences and knowing about the phenomenon. The analysis shows that it is possible to understand the experience of a pedagogy of listening in terms of an enlightenment – Sapere aude – underpinned by a transcendental ontology, and as a trauma – Parrhesia – drawing from a relational ontology. These experiences can overlap and occur in the same individual. The ontological underpinnings will, however, be conclusive of to what extent a pedagogy of listening can be practiced with an openness towards change and a multiplicity of different theoretical and didactic possibilities in relation to the pedagogical practices performed. This becomes especially apparent in the practicing of deconstructive talks around documented practices.
Por uma psicologia que (re)conheça a todos/as
Authors: Amaral Caroline , Ribeiro Paula Regina Costa , Barros Suzana da Conceição de 
Published: December 2022

O artigo busca analisar alguns elementos curriculares que são norteadores para a formação em psicologia no que diz respeito às questões de gêneros e sexualidades. Para tanto, foram analisadas as Diretrizes Curriculares Nacionais para os cursos de Psicologia bacharelado e os Projetos Pedagógicos dos cursos de Psicologia de cinco universidades federais do extremo sul do Brasil, a saber: Universidade Federal do Rio Grande – FURG, Universidade Federal de Pelotas – UFPEL, Universidade Federal de Santa Maria - UFSM, Universidade Federal do Rio Grande do Sul – UFRGS e Universidade Federal de Ciências da Saúde de Porto Alegre – UFCSPA. O referencial teórico-metodológico utilizado está baseado em Michel Foucault e nos estudos de Gênero e Sexualidade nas vertentes pós-estruturalistas. Dentre os resultados encontrados, percebeu-se que as discussões de gênero e sexualidade, nas Diretrizes Curriculares e nos Projetos Pedagógicos, quando mencionadas, são feitas de maneiras a tangenciar a formação de psicólogos/as, não se constituindo como discussões centrais nos documentos.
Faktor-Faktor Yang Mempengaruhi Opini Going Concern Pada Saat Pandemi Covid 19
Authors: Hasmi Evi Yana , Syaipudin Usep , Eka Putri Widya Rizki 
Published: December 2022

Going concern becomes a problem that must be addressed by management in managing the company, so that the company continue to operate for a long time especially during a pandemic where the economic situation is unstable and makes the going concern company's disrupted. This study aims to analyze the Effect of company growth, financial condition, opinion shopping and previous year’s audit opinion to the acceptance of going concern audit opinion during covid 19 pandemic . The sampling technique used in this study is purposive sampling with a total sample of 48 infrastructures companies listed on the Indonesia Stock Exchange during pandemic the period of research year 2019-2020. Hypothesis testing of this research is done by logistic regression analysis. The result of this study shows that company's growth have no effect significant on the going concern audit opinion, opinion shopping have no effect significant on the going concern audit opinion, financial condition have no effect significant on the going concern audit opinion, the previous year audit opinion have effect significant on the going concern audit opinion.
SIKAP DAN FAKTOR YANG MEMENGARUHI KONSUMEN DALAM PEMBELIAN BAKSO CURAH DI KOTA BANDAR LAMPUNG
Authors: Sepriadi Rahmat , Lestari Dyah Aring Hepiana , Riantini Maya 
Published: December 2022

This study aims to analyze the attitude of consumers and the factors that influence the purchase of meatballs bulk in Bandar Lampung. The markets which are analyzed in this research are Way Halim Market, Koga Market, and Gintung Market. The method that is used in this study is a survey method. Respondents in this study were selected randomly using the Accidental Sampling method. Respondents in this study were consumers of bulk beef meatballs that had bought bulk beef meatballs at least 3 times in the last 2 months. Types of data used in this study are primary data and secondary data. Before analyzing attitudes by Fishbein's multi-attribute analysis, the validity and reliability tests are first performed. To determine the factors that influenced the number of purchases of beef meatballs in bulk in Bandar Lampung City, multiple linear regression analysis is performed. Most respondents were housewives. The reaserch showed that attribute with the highest attitude score was the endurance attribute, while the cleanliness attribute, was the attribute with the smallest score. Factors that influence the number of consumers who bought meatballs in bulk were the price of bulk meatballs, the price of fish meatballs, the price of mustard greens, and the tastes of consumers. Fish meatballs were substitutes for bulk meatballs, if the price of bulk meatballs increases, consumers will choose to consume fish balls. Mustard was a complementary item from bulk meatballs, if the price of mustard greens increase, the purchase of bulk meatballs will decrease. Consumers who like the meatballs will tend to buy bulk meatballs with more amount than consumers who don’t like. Key words: attitude, consumers, decision, meatballs, purchasing
PENGARUHCAREER DEVELOPMENT DAN WORK-LIFE BALANCE DIMEDIASI OLEH EMPLOYEEENGAGEMENT TERHADAP TURNOVER INTENTION
Authors: Ningsih Ni Nyoman Dwi Ari Candra , Ni Made Yudhaningsih  , I Made Anom Arya Pering  
Published: December 2022

Abstract
Human Resources (HR) is the main element of the organization. Developing yourself and providing a balanced work life can minimize the rate of employee turnover or termination (turnover intention). This study has the urgency of the turnover rate at PT. Bank Rakyat Indonesia (Persero) Tbk. Denpasar Gajah Mada Branch Office which will increase by 7 people in 2021 and its relationship with career development and work life balance. The researcher aims to determine the effect of career development and work-life balance mediated by employee engagement on turnover intention. Hypothesis Testing using Hypothesis Testing (F-test) in the ANOVA Model and Hypothesis Testing (T-test) in the Coefficients Model with quantitative data with a sample of 80 people from a population of 393 based on the Slovin Model with the instrument in the form of a questionnaire. The results obtained are F_calculated career development, work life balance and employee engagement 1,203 and Sig. 0.315 > 0.050, it can be stated that career development has "not significant" effect on turnover intention, work-life balance has "not significant" effect on turnover intention, career development has "positive and significant" effect on employee engagement, work-life balance has "positive and significant" effect on employee engagement, career development and work life balance mediated by employee engagement have "not significant" effect on employee engagement, but have a positive and significant effect on turnover intention.So it is important for the company to provide opportunities for every employee to improve their career path but still pay attention to work balance.