bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Malaria Case Surveillance System in KwaZulu-Natal Province, South Africa, 2022: A focus on DHIS2
Authors: Mabona Maxwell , Zwane Thembekile , Raman Jaishree , Kuonza Lazarus , Mhlongo Babongile , Bapela Poncho 
Published: September 2023

Abstract

Background South Africa set a target to eliminate malaria by 2023, with KwaZulu-Natal (KZN) Province the malaria-endemic province closest to achieving this goal. Objective two of the National Malaria Elimination Strategic Plan (NMESP) focused on strengthening surveillance systems to support the country’s elimination efforts. Regular evaluations of the malaria surveillance systems against the targets of the NMESP objective are crucial in improving the system's performance and impact. This study aimed to assess whether the malaria surveillance system in KwaZulu-Natal Province meets the NMESP surveillance objective and goals. Methodology: A mixed-methods cross-sectional study design was used to evaluate the malaria surveillance system, focusing on the District Health Information System 2 (DHIS2). The study assessed the data quality, timeliness, simplicity, and acceptability of the system. Key personnel from the KZN Province malaria control program were interviewed using self-administered questionnaires to evaluate their perception of the system's simplicity and acceptance. Malaria case data from January 2016 to December 2020 were extracted from the DHIS2 and evaluated for data quality and timeliness. Results The survey respondents generally found DHIS2 acceptable (79%, 11/14) and easy to use (71%, 10/14), stating that they could readily find, extract, and share data (64%, 9/14). Overall data quality was good (88.9%), despite some variables having low completeness and data availability. However, case notifications were not timely, with only 61% (2,622/4,329) of cases reported within 24 hours. During the 5-year study period, the DHIS2 captured 4,333 malaria cases. The majority of cases (81%, 3,489/4,330) were categorized as imported, mostly from Mozambique, while the majority of patients (67%, 2,914/4,333) were male. Conclusion The malaria surveillance system largely met the NMESP surveillance strategic goals, but it fell short of the overarching surveillance objective of achieving 100% notification of cases within 24 hours. The majority of reported cases in KZN Province are imported from neighboring countries. Engaging with healthcare professionals responsible for case notification is crucial to improve notification timeliness.
Knowledge and Attitudes Toward Anaphylaxis to Local Anesthetics in Dental Practice: A Latin American Cross-Sectional Study
Authors: Cherrez-Ojeda Ivan , Gallardo-Bastidas Juan C. , Borrero Gabriela Rouillon , Silva Paola Andrea Mena , Sarfraz Zouina , Sarfraz Azza , Cano Leonardo , Robles-Velasco Karla 
Published: September 2023

Abstract
Objectives: This study aims to assess Latin American dentists' knowledge, preparedness, and competency in managing anaphylactic reactions to LAs.
Materials and Methods: A cross-sectional study was conducted using a web-based survey from November 2021 to February 2022 targeting board-certified dentists in various Latin American countries. The survey comprised 26 structured questions focused on demographic information, knowledge, and attitudes toward anaphylaxis. Chi-square tests and logistic regression models were performed in Stata 17.0.
Results: The majority of respondents (81.9%) were from Ecuador with a mean age of 35 years and an average of 10 years of professional experience. Lidocaine was the most frequently used local anesthetic (88.1%). While 85.2% could identify dyspnea as a symptom of anaphylaxis, only 50.1% knew the correct route for epinephrine administration, and just 43.5% had epinephrine in their emergency kits. Confidence in managing anaphylactic reactions was low (9.6%). Regional comparisons indicated no significant differences in knowledge and attitudes, except professionals from Ecuador displayed more confidence in managing anaphylaxis (P=0.002). In multivariate regression, older age was inversely related to both knowledge of anaphylaxis management and the possession of epinephrine (P=0.003 and P=0.0001, respectively).
Conclusion: There is a significant gap in the knowledge and preparedness of Latin American dentists concerning anaphylaxis management.
Clinical Relevance: The study's findings underscore the need for educational interventions to improve the understanding and readiness of dental professionals in handling anaphylactic emergencies and ultimately improving patient safety in dental practice.
A secure user authentication scheme for crypto-wallet in Iot environment
Authors: Truong Toan-Thinh , Tran Minh-Triet , Duong Anh-Duc 
Published: September 2023

Abstract

As 4.0-revolution makes a extraordinary affect on the way we work in numerous areas, data security is still one of the issues that continuously get extraordinary considerations. Presently, the prevalent environment is internet of things (Iot) since it can connect a huge number of diﬀerent gadgets in an increasingly wide range, and this leads to the risk of information leakage. Besides, the field of crypto-currency is a hot topic with a lot of sophisticated thefts, so the progressively utilization of crypto-wallets should protect the transactions from hurt. Clearly, Iot could bea promising and challenging environment for quick and secure crypto-currency exchanges. Recently, Lee et al proposed a three-factor anonymous user authentication scheme for Iot, and this is an improved result from Dhillon and Kalra’s work. In 2023, Wang et al also proposed a lightweight mutual and transitive authentication mechanism for Iot network. All works are builtfrom highly reliable formal analysis, but we discovered some limitations such as replays or privileged insider attacks in their works. In addition, we propose a secure improvement to provide time-efciency, reasonable energy-consumption as well as more suitable for crypto-wallet applications in Iot environment.
Coordination challenges in wind energy development: Lessons from cross-case positive planning approaches to avoid multi-level governance ‘free-riding’
Authors: Weber Jessica 
Published: September 2023

Abstract
Achieving national renewable energy targets presents multi-level governance challenges, such as uneven progress and discrepancies arising from varying subordinate specifications and incentives on wind energy development. Governments have commenced adopting ‘positive planning’ that aim to integrate energy targets with spatial and land use planning, yet detailed discussions regarding wind energy development remain scarce. This paper assesses three cases in Germany and Sweden within criteria-based explanatory case studies to provide planners and policy makers with knowledge on key factors, lessons learned, and challenges. Positive planning appears to center on a strong energy target focus, limited space, and a balanced approach, shaped by the socio-political context. While Germany more recently embraces positive planning, Sweden started ambitiously on a national level but encounters policy and planning challenges. Planning agencies play an important role in promoting wind energy targets at mid-scale levels; however, legally binding targets matter. Striking a balance between energy targets and addressing land use concerns without disregarding them requires managing a delicate trade-off. Early communication and inter-agency collaboration, as seen in Sweden, might facilitate identifying compromises, navigating trade-off between species protection and renewable energy and offering municipal incentives. Nonetheless, satisfactory spatial trade-offs for long-term proof of concept remains a challenge.
Current Perspectives of Matrix Metalloproteinase 11 (MMP11) as a Diagnostic
and Therapeutic Target for Cancer
Authors: Shobana Asokan , Deeksha Remella Venkata , Rahman Syed Ali Abdul , Thangaswamy Tiviya , Oviya Revathi Paramasivam , Gopisetty Gopal 
Published: September 2023

Abstract:
Matrix metalloproteinase 11 (MMP11), also known as stromelysin-3, is a member of the
matrix metalloproteinases family of proteins that are involved in physiological and pathological extracellular
matrix remodelling. MMP11 does not hydrolyse classical MMP substrates, such as laminin
and fibronectin, and many of its substrates remain unknown, piquing the interest of researchers. Several
studies have reported the role of MMP11 in inducing tumour growth by inhibiting apoptosis and
promoting cancer cell migration and invasion. Various reports have shown its potential as a diagnostic
and prognostic marker in a majority of cancers. MMP11 also induces an immune response as a
tumour-associated antigen, and recent evidence shows the involvement of many microRNAs in targeting
MMP11 in cancer, with prospective future applications in cancer immunotherapy and gene
silencing. Owing to the importance of MMP11 in both cancer diagnosis and therapy, there is a need
for deeper understanding of its mechanism and role in tumour progression. The current review focuses
on the role of MMP11 in cell signalling pathways, its expression status in various cancers, and its
potential in cancer treatment.
Real-world Safety and Effectiveness of Insulin Glargine 300 U/mL in
Participants with Type 2 Diabetes Mellitus During the Period of Ramadan
in Four Countries (Egypt, Jordan, Lebanon, and Turkey): A Prospective
Observational Study
Authors: Hassanein Mohamed , Shaltout Inass , Malek Rachid , Assaad  Khalil Samir , Ballout Hajar , Annabi Firas , Shereen Mark 
Published: September 2023

Aim:
This non-interventional observational study aimed to describe the clinical outcomes of patients with T2DM treated with Gla-300 during the period of Ramadan.

Background:
Type 2 diabetes mellitus (T2DM) patients who decide to fast during the holy month of Ramadan face several challenges in achieving glycemic control without increasing the risk of hypoglycemia. Insulin glargine-300 (Gla-300) has well-established safety and efficacy in improving glycemic control in multiple randomized clinical trials (RCTs). However, limited evidence is available regarding its safety and effectiveness during fasting.

Objective:
The objective of this study was to assess the safety and clinical outcomes of insulin glargine-300 (Gla-300) in T2DM patients before, during, and after Ramadan.

Methods:
We conducted a prospective, observational, non-comparative, multicenter study on patients with T2DM currently treated with Gla-300 who planned to fast and continue on Gla-300 during Ramadan in four countries (Egypt, Jordan, Lebanon, and Turkey). The study outcomes included the change in glycemic parameters and incidence of hypoglycemia before, during, and after Ramadan.

Results:
One hundred and forty T2DM patients were included. Nearly 61% of the included patients had a duration of diabetes of <10 years. The mean Gla-300 daily doses during the pre-Ramadan, Ramadan, and post-Ramadan periods were 22.2 ±7.4, 20.4 ±7.5, and 22.5 ±4.7 IU, respectively. The mean change values from pre-Ramadan to Ramadan and post-Ramadan were -1.7 ±6.9 IU and 0.5 ±4.7 IU, respectively, among the included patients. The mean HbA1c decreased during the study period initiating from 7.9 ±1.4% pre-Ramadan to 6.9 ±0.4% post-Ramadan. The overall HBA1c target value was 6.9 ±0.4%, while the HbA1c target was achieved by 29 patients (21.9%). The mean fasting blood glucose (FPG) showed a reduction from baseline value in the post-Ramadan period by -0.9 ±2.3mmol/L. Five patients (3.57%) had symptomatic documented hypoglycemia during Ramadan, and none was considered to have severe hypoglycemia.

Conclusion:
Our study showed that insulin Gla-300 maintained the glycemic control of T2DM patients who decided to fast during the holy month of Ramadan without increasing the risk of hypoglycemia. Regular self-monitoring of blood glucose levels during Ramadan is highly recommended to avoid possible complications.
Potential use of Acrocomia aculeata Pulp Oil in the Modulation of Chronic
Non-communicable Diseases, Especially in Diabetes: A Systematic Review
Authors: de Souza Cazarim Maurílio , Aleixo Davi Trombini , da Cruz-Cazarim Estael Luzia Coelho , Abd El-Salam Mohamed A. , Pittella Frederico 
Published: September 2023

Introduction:
The fruit oil from Acrocomia aculeata (Macauba or Bocaiuva) is highly rich in antioxidants and other bioactive compounds, emerging as a natural source of high potential for the modulation of chronic non-communicable diseases (NCDs), like diabetes. Its effects on chronic NCDs are poorly studied yet. Our review aimed to evaluate the therapeutic results of pharmaceutical preparations containing Acrocomia aculeata pulp oil that are used for chronic NCDs.

Method:
A search was performed using PICO acronyms in English, Portuguese, and Spanish languages in the MEDLINE®, PubMed, EMBASE, Scopus, LILACs, and CENTRAL Cochrane Library databases. The degree of agreement for selection and eligibility was significant (Kappa= 0.992; 95% CI: 0.988-0.996). The difference between the intervention and control groups for blood glucose reduction was 63.5 ± 69.5 mg/dL (p<0.0001).

Result:
Overall, an improvement percentage of 55.1 ± 0.1 was observed for the variables associated with chronic NCDs, which represented 89.96% of the relative risk reduction (efficacy).

Conclusion:
The Acrocomia aculeate pulp oil exhibited promising results in experimental studies for glycemic control and reduction of a specific tumor, indicating a good potential to be explored for chronic NCDs treatment.
Formulation and Evaluation of Cola acuminata Gum-based Mucoadhesive Sustained-release Matrix Tablets of Diclofenac Sodium
Authors: Bamigbola Emmanuel Adelaja , Attama Anthony Amaechi , Kenechukwu Franklin Chimaobi , Oraeluno Jude Nkemjika 
Published: September 2023

Objective:
This study aimed to evaluate Cola acuminata gum (CAG) for the formulation of
mucoadhesive sustained-release matrix tablets of diclofenac sodium.

Methods:
Different batches of granules containing CAG and 100 mg of DS in ratios 0.5:1, 1:1, 2:1,
and 3:1 were prepared, compressed into tablets, and evaluated for mucoadhesive strength, swelling index,
and drug release in SGF (pH 1.2) and SIF (pH 7.4).

Results:
Swelling indices and mucoadhesive strengths of the tablets were pH-dependent. Swelling indices
of 56 + 2.03 to 121 + 2.19% and mucoadhesive strengths of 7.25 + 1.45 to 15.43 + 2.71 g/cm2
obtained at pH 7.4 were significantly higher (p<0.05) than swelling indices of 25 + 2.43 to 47 + 3.15%
and mucoadhesive strengths of 5.52 + 0.76 to 9.22 + 1.95 g/cm2 obtained at pH 1.2. The percentage
release of DS from the matrix tablets at pH 1.2 after 2 h (T2h) was insignificant. However, the percentage
of drug release at pH 7.4 was significant for all the batches and dependent on the CAG concentration.
The drug release was in the order of batches containing 3 g (80.44 + 7.75) < 2 g (86.35 + 5.65) <
1 g (90.08 + 6.14) < 0.5 g (99.70 + 3.90). The time for maximum drug release was 7 h (T7h) for CAG
containing 0.5 g and 10 h (T10h) for other batches.

Conclusion:
This study showed that CAG could be useful for mucoadhesive sustained drug delivery.
The Reporting and Methodological Quality of Systematic Reviews Underpinning Clinical Practice Guidelines Focused on the Management of Cutaneous Melanoma: Cross-Sectional Analysis
Authors: Khalid Mahnoor , Sutterfield Bethany , Minley Kirstien , Ottwell Ryan , Abercrombie McKenna , Heath Christopher , Torgerson Trevor , Hartwell Micah , Vassar Matt 
Published: September 2023

Background
Clinical practice guidelines (CPGs) inform evidence-based decision-making in the clinical setting; however, systematic reviews (SRs) that inform these CPGs may vary in terms of reporting and methodological quality, which affects confidence in summary effect estimates.

Objective
Our objective was to appraise the methodological and reporting quality of the SRs used in CPGs for cutaneous melanoma and evaluate differences in these outcomes between Cochrane and non-Cochrane reviews.

Methods
We conducted a cross-sectional analysis by searching PubMed for cutaneous melanoma guidelines published between January 1, 2015, and May 21, 2021. Next, we extracted SRs composing these guidelines and appraised their reporting and methodological rigor using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and AMSTAR (A Measurement Tool to Assess Systematic Reviews) checklists. Lastly, we compared these outcomes between Cochrane and non-Cochrane SRs. All screening and data extraction occurred in a masked, duplicate fashion.

Results
Of the SRs appraised, the mean completion rate was 66.5% (SD 12.29%) for the PRISMA checklist and 44.5% (SD 21.05%) for AMSTAR. The majority of SRs (19/50, 53%) were of critically low methodological quality, with no SRs being appraised as high quality. There was a statistically significant association (P<.001) between AMSTAR and PRISMA checklists. Cochrane SRs had higher PRISMA mean completion rates and higher methodological quality than non-Cochrane SRs.

Conclusions
SRs supporting CPGs focused on the management of cutaneous melanoma vary in reporting and methodological quality, with the majority of SRs being of low quality. Increasing adherence to PRISMA and AMSTAR checklists will likely increase the quality of SRs, thereby increasing the level of evidence supporting cutaneous melanoma CPGs.
Congenital Telangiectatic Erythema: Scoping Review
Authors: Wojtara Magda Sara , Kang Jayne , Zaman Mohammed 
Published: September 2023

Background
Congenital telangiectatic erythema (CTE), also known as Bloom syndrome, is a rare autosomal recessive disorder characterized by below-average height, a narrow face, a red skin rash occurring on sun-exposed areas of the body, and an increased risk of cancer. CTE is one of many genodermatoses and photodermatoses associated with defects in DNA repair. CTE is caused by a mutation occurring in the BLM gene, which causes abnormal breaks in chromosomes.

Objective
We aimed to analyze the existing literature on CTE to provide additional insight into its heredity, the spectrum of clinical presentations, and the management of this disorder. In addition, the gaps in current research and the use of artificial intelligence to streamline clinical diagnosis and the management of CTE are outlined.

Methods
A literature search was conducted on PubMed, DOAJ, and Scopus using search terms such as “congenital telangiectatic erythema,” “bloom syndrome,” and “bloom-torre-machacek.” Due to limited current literature, studies published from January 2000 to January 2023 were considered for this review. A total of 49 sources from the literature were analyzed.

Results
Through this scoping review, the researchers were able to identify several publications focusing on Bloom syndrome. Some common subject areas included the heredity of CTE, clinical presentations of CTE, and management of CTE. In addition, the literature on rare diseases shows the potential advancements in understanding and treatment with artificial intelligence. Future studies should address the causes of heterogeneity in presentation and examine potential therapeutic candidates for CTE and similarly presenting syndromes.

Conclusions
This review illuminated current advances in potential molecular targets or causative pathways in the development of CTE as well as clinical features including erythema, increased cancer risk, and growth abnormalities. Future studies should continue to explore innovations in this space, especially in regard to the use of artificial intelligence, including machine learning and deep learning, for the diagnosis and clinical management of rare diseases such as CTE.
India 2075
Authors: Giudice Baca Victor , Zapata Tito Rosario 
Published: September 2023

El Banco de inversión Goldman Sachs creó en Octubre 2003 el pronóstico de los BRICS 2050 (Brasil, Rusia, China y Sudáfrica). El pronóstico del banco sorprendió a los países desarrollados de Europa y EE.UU. Hoy los BRICS son la Tercera Potencia Mundial, luego de EE.UU y la Unión Europea. El PBI de los BRICS supera el PBI de 20 países desarrollados (G - 20). La India 2075 sobrepasará a Inglaterra, Alemania, Francia y EE.UU en PBI y se posicionará luego de China, delante de EE.UU y la Unión Europea.
India también sobrepasará en población a China. Santanu Sengupta, experto de Goldman Sachs, opina que la población de la India posee la composición ideal de jóvenes, niños y ancianos es apta para la edad laboral. El Estudio pronostica que el 2075 China tendría un PBI de 57 trillones. La India 52.5 trillones, EE.UU 51.5 trillones y la Unión Europea 30.3 trillones.
Exploring Undergraduate Students’ Perception of 4IR Digital Era at a Higher Education Institution in South Africa
Authors: Cele Siphiwe , Bhana Anrusha , Matli Walter 
Published: September 2023

Objective –This study aims to explore undergraduate students’ perceptions and knowledge of 4IR in relation to their accounting curriculum and careers at HEIs in KwaZulu-Natal. The digital revolution is altering the way in which people and organizations work, as well as nearly every other aspect of human life. Furthermore, 4IR is re-writing society's fundamental rules, which highlights the need for this paper.Methodology –This study used a census approach to gather quantitative data from one of South Africa's HEIs, via an online questionnaire link created with the Microsoft Forms application. The study was conducted online with a total population of 257 exit-level students from the Diploma in Accounting programme, the population that was targeted. The sample size was 172 out of 257 students, with a response rate of 66.9%.Results –The findings indicated that students' knowledge of 4IR is limited, with only 56.4% of students having an understanding of what big data, artificial intelligence and the Internet of Things (IoT) are.Research limitations/implications –There is a need to close the knowledge gap between Financial Accounting students’ knowledge of 4IR trends like big data, artificial intelligence (AI) and the Internet of Things (IoT) and curriculum content. The study's population was limited to exit-level students at one Higher Education Institution, hence the study's findings may not be generalizable to all HEIs.Novelty/Originality –The study’s novelty contributes to the growing body of research on how accounting technology can improve Financial Accounting education. The study provides an original perspective on the applicability of 4IR Accounting software systems and packages in a South African context, since most related studies were not conducted in South Africa. Furthermore, the study illustrates the importance of 4IR in the accounting curriculum.