bluuebunny/crossref_metadata_2025_split huggingface dataset:
Satisfying the patient journey: optimal service configuration for online health service platforms
Authors: Jia Li , Ying Lu , Zeyu Peng , David Yen 
Published: May 2023

Abstract
Using and developing online health service platforms are flourishing in recent years. Surprisingly enough and also unfortunately, the vast majority of those online health service startups don't survive for a long time. For this reason, it is significant to investigate why some of the online medical service platforms have sustained, while others haven’t. In specific, this study intends to investigate the optimal service configuration of online health service platforms from the perspective of patient’s journey. With the single service level, a frequency-rarity framework is proposed to analyze the importance of individual services, while at the multiple service level, the rule of service chain continuity is adopted to analyze the service configuration strategy. Further, an fsQCA analysis based on 14 most influential online health service platforms in China confirms the proposed research hypotheses. The obtained results suggest the configurations that lead to a high customer retention may require the presence of at least one of high frequency services (i.e., health information or e-consultation), while the configurations that lead to a high customer acquisition may require the presence of at least one of high rarity services (i.e., e-consultation or online pre-registration). The continuity of service chain is proved to be essential for both high customer retention and high customer acquisition. In addition, the basic services at the beginning of the service chain is deemed to be vital for the high customer acquisition.
Bismuth porphyrin anchored reduced graphene oxide nanocomposites as fascinating photocatalyst for rhodamine B dye degradation
Authors: Yasmeen Rehana , Bajju Gauri Devi , Sheikh Haq Nawaz 
Published: May 2023

Abstract
Herein, two porphyrins with bismuth metal incorporated in the porphyrinic core were synthesised having peripheral carboxyl and hydroxyl functional groups. The successful synthesis of free base porphyrin and their bismuth integrated metalloporphyrins was identified using 1H NMR spectroscopy, UV-Visible and Fourier transform infrared (FT-IR). Further, these bismuth based metalloporphyrins complex were doped with thermally reduced graphene oxide (TRGO) via simple solvothermal techniques. The intrinsic characteristics of prepared metalloporphyrins based reduced graphene oxide nanocomposites were examined by using various spectroscopic techniques like, photo-physical properties (UV–Visible spectroscopy and Fluorescence spectroscopy), Fourier transform infrared (FT-IR), powdered X-ray diffraction (P-XRD) patterns, FE-SEM and EDX analysis. At last, the photocatalytic degradation of rhodamine B (Rh-b) dye was demonstrated by the steady-state luminescence and ground-state absorption measurements, demonstrating the effectiveness of these nanocomposites as photocatalysts. The catalytic efficiency of RGO-Bi-P1 and RGO-Bi-P2 came out to be 94% and 93%, respectively.
Identification and fixing bottlenecks of a food manufacturing system using a simulation approach
Authors: Javadi Seyed Mahdi , Sadjadi Seyed Jafar , Makui Ahmad 
Published: May 2023

Abstract

In manufacturing systems, simulation modeling plays an important role in creating some changes instead of working on real systems. Manipulation in a real system is more costly than manipulation in a simulated model. In this research, we tried to use a simulation approach to recognize and minimize bottlenecks of a production line, which will decrease costs and improve productivity. To achieve our objectives, we chose a case and analyzed its production line. By using our case study strategy, we tried to collect our data and adapt a conceptual model of production processes drawing on an operation process chart (OPC). After that, we created a simulation model of the production processes by using the popular Arena simulation software 13.5. By running the Arena model, some bottlenecks were found. Ultimately, we proposed some solutions to obviate bottlenecks and reduce the total costs of production.
Research on rapid detection of characteristic parameters of aeroengine blade surface based on laser scanning
Authors: song junfang , He Lei , Sun Bin , Pu Yuanyuan , Wang Tengjiao 
Published: May 2023

Abstract
How to quickly and effectively detect and evaluate the profile quality of aeroengine blades and provide technical support for blade manufacturing has become one of the key technical problems in the field of aviation manufacturing. This paper studies the evaluation criteria of medium surface quality in the processing and manufacturing process of aeroengine blades, optimizes and innovates the fast extraction algorithms of various geometric parameters such as aeroengine blade section line, middle arc, front and rear edge center, front and rear edge radius, blade chord length and chord angle, and establishes the evaluation criteria of aeroengine blade surface. According to the geometric relationship of blade chord length and front / rear edge radius in blade section profile, the parameters are solved one by one through optimization algorithm, combined with non-contact laser scanning measurement, and the blade detection efficiency is improved by more than 40%.
Investigating the hidden mechanism underlying the tau interaction by methylene blue
Authors: Seo Dong-Hyun , Huh Yang Hoon , Yoo Hee-Jin , Cho Kun , Cheong Hae-Kap , Kim Eun-Hee , Choi Joonhyeok , Kim Hak Nam , Bang Jeong , Lim Jong-Soo , Lee Min Jung , Ryu Kyoung-Seok 
Published: May 2023

Abstract
Methylene blue (MB) has recently completed another Phase-3 clinical trial as the leuco-methylthioninium (LMT) bis(hydromethanesulfonate) (LMTM) for the treatment of Alzheimer's disease (AD). We aimed to elucidate the detailed mechanisms of MB as a tau aggregation inhibitor, focusing on tau monomers and fibrils. Methylthioninium (MT+) oxidized the Cys residues of tau proteins (2N4R, K18, and dGAE) to disulfide bonds by utilizing O2 molecule, independent of the MB redox-cycle between MT+ and LMT. The previous MB-mediated 1H-15N heteronuclear single quantum coherence (HSQC) peak-broadenings in a large area (> 60 residues) of 2N4R likely resort to disulfide-centered hydrogen bonds, specific long-range interactions with the NH, and the basic side-chains in solution. In addition, at least two different MB binding sites were identified for dGAE fibrils, and the different Ki values of MT+ and LMT were measured against thioflavin-T (ThT), which could serve as a molecular basis to support the disaggregation activity of MB.
Behavioral experiments confirm that interventions with psychological factors facilitate weight management: a prospective cohort study
Authors: Zhao Ting-Yan , Li Jia-Le , Bai Wen-Ju , Tian Min , Li Zhen , Ji Zhao-Hua 
Published: May 2023

Abstract
The proportion of overweight or obese people in China was increasing year by year, and the objective demand for weight loss was stronger and stronger. Physical exercise was one of the simplest and most important ways to lose weight, but there were still objective reasons such as the inability to adhere to exercise, which made the effect of physical exercise on weight management not good. Previous studies had shown that psychological factors such as grit and motivation were related to individuals’ exercise behavior. However, the effect of additional extrinsic motivation on exercise behaviors remained unknown. Here, a new "exercise-incentive" model through behavioral experiments was conducted. The model showed that grit and motivation had an obvious relationship with individuals’ exercise behavior. Extrinsic motivation could significantly change individuals’ exercise behavior, and different psychological factors were associated with different exercise patterns. Meanwhile, we established the relationship among psychological factors, exercise patterns, and lifestyle factors, and finally identified effort, the sub-dimension of grit, as the core psychological factor for weight management. Our study, through behavioral experiments, provided a psychological perspective on weight management and potential targets for psychological interventions.
Social Needs Analysis of a Transcranial Magnetic Stimulation Patient Cohort
Authors: Sullivan Luke , Tirrell Eric , Gobin Asi Polly , Carpenter Linda 
Published: May 2023

Abstract
Purpose Little research exists on how a depressed patient’s social wealth affects their access and clinical benefit from Transcranial Magnetic Stimulation (TMS) therapy.Methods We performed a retrospective analysis of patients who underwent TMS therapy for MDD. To assess social assets, we implemented a modified version of the AHC-HRSN Screening Tool.Results We found that generally, the n = 74 patients had minimal deficits regarding basic needs. A majority reported social isolation and disabling symptom burden.Conclusion This cohort had elevated levels of social assets, though symptoms may contribute to social disengagement. There is potential to connect patients with higher social burdens to TMS.
The effect of trees on arbuscular mycorrhizal fungi and nutrient acquisition of grassland plant communities in three temperate silvopastoral systems
Authors: Murray Shevani , Avezaat Bram , Guilmot Robin , Hogenboom Anne A. , Lareau Don H. , Wear Brigitte , Moinet Gabriel Y.K. 
Published: May 2023

Abstract

Aims
Despite their importance for plant nutrient acquisition, the role of arbuscular mycorrhizal fungi (AMF) in tree-crop interactions in silvopastoral systems is unclear. The aim of this study was to investigate the effect of trees on AMF biomass and grassland root colonisation in relation with nutrient acquisition of the grassland plant community (GPC) in temperate permanent grazed silvopastures.
Methods
Samples were collected at two soil depths (0–20 cm and 20–60 cm) in three paired sites on commercial farms, each combining an apple (Malus domestica)-based silvopasture adjacent to a grassland managed identically excepting the presence of trees. Soil chemical and physical properties were determined. AMF biomass was measured by extracting and quantifying Neutral Lipid Fatty Acids (NLFA). GPC roots were isolated from the soil samples and their colonisation by AMF, biomass, and N and P concentrations were measured.
Results
Apple trees had an overall negative effect on AMF biomass, colonisation, and GPC root biomass. Trees increased soil mineral N and N concentrations in GPC roots, which were likely N-limited at all sites as indicated by N:P ratios comprised between 5 and 9.
Conclusions
Rather than mediating interactions between trees and the GPC, AMF colonisation and biomass likely followed direct effects of trees on nutrient cycling and consequential changes in root biomass. We speculate that trees lifted nutrient limitations in the topsoil due to ‘hydraulic lift’ and ‘nutrient pumping’ mechanisms which would have decreased root biomass by shifting the functional equilibrium of the GPC towards above-ground production.
Impact of covid 19 on the financial performance of Tunisian companies
Authors: nasfi faten , saidi basma 
Published: May 2023

Abstract
Purpose- The purpose of this study is to evaluate theoretically and empirically the impact of the health crisis of covid-19 on the financial performance of Tunisian listed companies. Design/methodology/approach –The methodology of this research is based on a literature review and information collected from 40 Tunisian firms listed on the stock exchange. To estimate this result using a dynamic panel data model by the method of moments generalized during the period 2013–2020 which allows us to deal with the endogeneity problem of some independent and control variable. Findings –results of this study reveal that (1) the covid-19 crisis has certainly hit Tunisian companies hard, and they have suddenly found themselves in an unprecedented situation, both in terms of scope and severity while also revealing their financial vulnerability. (2) the crisis has a negative impact on the financial performance of Tunisian firms and was more pronounced in the industrial sector. (3) While size has a positive impact on firm performance, turnover, debt and the covid19 have a negative effect on the performance of Tunisian firms. Originality/value – This study provides information that supports investors, regulators and executive managers in countries that have used containment to control the health situation. A well-structured balance sheet would improve the financial performance and risk management of the listed companies, especially in times of crisis and pandemics.
Neoadjuvant Chemotherapy plus Surgery versus Direct Surgery in Senile Patients with with Gastric Cancer: Single-Center Retrospective Cohort Study
Authors: SAH BIRENDRA KUMAR , Zhenjia Yu , Jian Li , Sheng Lu , Yanan Zheng , Zhenglun Zhu , Chen Li , Min Yan , Zhenggang Zhu 
Published: May 2023

Abstract

Background
Despite the lack of decisive research advocating neoadjuvant chemotherapy there is a broad consensus that it is beneficial for gastric cancer in terms of survival. However, there is no comparative research on whether it is similarly helpful in senile patients with the age above 75 years old. Here we compared the survival rate between neoadjuvant plus surgery with Direct Surgery.
Methods
We analyzed 79 patients with locally advanced gastric cancer who were preoperatively suspicious of serosa positive or beyond (cT4a or cT4b); or extensive lymph node involvement (cN3). Postoperative complications and overall survival rate were compared between the patients who underwent neoadjuvant chemotherapy (NAC) plus surgery and the patients who had direct surgery.
Results
A total of 15 (19%) patients underwent neoadjuvant chemotherapy and 64 (81%) patients had direct surgery. The median follow-up time was 34 months (range of 24–60 months). While the median survival time was not reached in the direct surgery group, the median survival time for the NAC plus Surgery Group was 37 months. Two years of overall survival (OS) for the patients in the NAC plus Surgery group and direct surgery group were 53.3% and 70.3% respectively. There was no statistical difference between the two groups (p > 0.05) in overall postoperative complication and length of postoperative stay.
Conclusions
Reduced does of neoadjuvant chemotherapy was feasible in senile patients. There was no difference in survival rate between the patients who had neoadjuvant plus surgery compared to those who had direct surgery. While this result contradicts the previous assumption that neoadjuvant chemotherapy is beneficial for late-stage gastric cancer patients, a well-controlled prospective study is mandatory for a better understanding of whether neoadjuvant chemotherapy is beneficial to senile patients too.
Experimental Study on Icon Attention Difference Based on Multidimensional Visual Variables
Authors: Deng Qianwei , Wong Chee-Onn , Sitharan Roopesh , Meng Xiangbin 
Published: May 2023

Abstract
Cognition plays an important role in psychology. The study of cognition is divided into an important research direction: cognitive psychology. The process by which users process information conveyed by icons is icon attention, and cognitive psychology can only be used as a theoretical basis to study internal mechanism of icon attention difference. By studying internal mechanism of user recognition of icons, the icon design is optimized to make its visual form more consistent with the cognitive law of user recognition of icons, so as to improve efficiency of icon attention, achieve the purpose of improving smoothness of human-computer interaction in digital interface, and provide reliable theoretical basis and feasible icon optimization design criteria for improving user experience in digital interface. Because icons are affected by many attributes including color, background, outline, shape, detail, direction, size, etc., these attributes as visual characteristics of icons will inevitably affect user's cognitive process of icons. Therefore, to carry out scientific and rigorous research on icon concern, it’s necessary to carry out experimental research on difference of concern of multi-dimensional visual variables of icons, so as to determine the more representative attributes of multi-dimensional visual variables, and provide experimental support for future icon design suggestions.
Coverage of policies to improve antimicrobial stewardship in low and middle income countries: Results from the first Global Survey of Experts on Antimicrobial Resistance
Authors: Ya Kyaw Zay , Lambiris Mark J. , Levine Gillian A , Tediosi Fabrizio , Fink Günther 
Published: May 2023

Abstract

Background
Antimicrobial resistance (AMR) constitutes a major threat to global health security. While antimicrobial misuse or overuse is a one of the main drivers for AMR, little is known regarding the extent to which this is due to a lack of national government-led efforts to enforce rational antimicrobial use in low and middle-income countries (LMICs).
Methods
To assess antimicrobial stewardship and national implementation measures currently in place for optimizing antimicrobial use and slowing the spread of AMR through expert’s lens, we invited public health experts from 138 LMICs to participate in a Global Survey of Experts on Antimicrobial Resistance (GSEAR). Key coverage measures as reported by experts were compared to across countries and also compared to estimates collected in the 2020-21 World Health Organization organized Tripartite AMR Country Self-assessment Survey (TrACSS).
Results
A total of 352 completed surveys from 118 LMICs were analysed. Experts in 67% of the surveyed countries reported a national action plan (NAP) on AMR, 64% reported legislative policies on antimicrobial use, 58% reported national training programs for health professionals, and 10% reported national monitoring systems for antimicrobials. 51% of LMICs had specific targeted policies to limit the sale and use of protected or reserve antibiotics. While 72% of LMICs had prescription requirements for accessing antibiotics, getting antibiotics without a prescription was reported to be possible in practice in 74% of LMICs. On average, country efforts reported in TrACSS were substantially higher than those seen in GSEAR.
Conclusions
Gaps in the implementation and enforcement of policies to reduce the risk of AMR in many LMICs remain large. Improved monitoring of national efforts as well as increased national efforts in the areas of enforcement and monitoring of antibiotic use are urgently needed to reduce inappropriate use and overuse in LMICs and to slow the spread of AMR globally.
Relationship between Sleep Disturbances and In Vitro Fertilization Outcomes in Infertile Women: A Systematic Review and Meta-Analysis
Authors: Habibi Farangis , Nikbakht Roya , Jahanfar Shayesteh , Ahmadi Mohammad , Eslami Maryam , Shahhosseini Zohreh 
Published: May 2023

Abstract
Background and Aim: Infertility means failure to achieve a clinical pregnancy after 12 months of regular unprotected intercourse or reproductive disorders. In this respect, in vitro fertilization has been acknowledged as the primary assisted reproductive technology technique for the fertilization of oocytes outside the female reproductive system, which is steadily increasing thanks to its prenatal safety. However, stress and anxiety, inextricably linked to sleep disorders, are likely to affect infertility and its treatment. Against this background, the present study was to investigate the relationship between sleep disturbances and IVF outcomes in infertile women.
Materials and Methods: Considering no language limits, the databases of PubMed (1996), Embase (1980), the Cochrane Library (2010), ProQuest (1995), and Web of Science (1997) were searched for the relevant articles published up to April 2023. The Newcastle-Ottawa Scale was then used to assess their methodological quality. Moreover, the random effects model and the STATA (v.11) software program were utilized to present the odds ratio with 95% confidence interval. Ultimately, the Begg’s test and funnel plots were recruited to examine publication bias and sensitivity analysis, thereby determining the impact of each study on its final results.
Findings: During the initial search, 425 articles were retrieved; however, five studies remained after the exclusion of the unrelated ones, including two and three cross-sectional and cohort studies, respectively. The review findings demonstrated that sleep disturbances were more common in women undergoing the IVF techniques than the general population. In addition, such disorders were associated with getting pregnant, oocyte retrieval, ovulation, live birth, and fetal weight. After combining the ORs reported in the cross-sectional studies with 95% CI based on the I2 index (OR=0.42, 95% CI=[0.23, 0.60], I2=0.0%) and the p-value of 0.901 for heterogeneity according to the fixed effects model, the relationship between sleep and pregnancy was approved. On the other hand, upon combining the ORs revealed in the cohort studies with 95% CI based on the I2 index (OR=1.02, 95% CI=[0.86, 1.18], I2=77.9%) and the p-value of 0.011 for heterogeneity with reference to the random effects model, the relationship between sleep and pregnancy was not confirmed.
Results: The study results established that sleep, as a modifiable parameter, could affect IVF outcomes. Therefore, health policymakers must develop effective interventions for the youth population along with childbearing policies to improve sleep as an important factor.
Evaluating the Accuracy of the Current Tuberculosis Scoring System in Screening Suspected Cases: A Quality Improvement Project
Authors: Hariri Bassem Al , Alharafsheh Ahmad E. , Omran Maya A. , Mohamedali Mohamed G. , Khalid Muayad Kasim , Chandra Prem , Alnaimat Ali M. , Mohammad Osama , Nashwan Abdulqadir J. 
Published: May 2023

Abstract
Background
Early identification and isolation of suspected Tuberculosis (TB) cases are crucial for reducing the risk of transmission to healthcare workers and other patients. The current TB scoring system, with a cutoff point of 4, has been widely used but lacks specificity. This quality improvement project aims to evaluate the accuracy of the current TB scoring system in screening suspected cases and explore the potential for improving the system's performance.
Methods
A retrospective analysis of 309 male patients presenting with respiratory symptoms was conducted at Hazm Mebaireek General Hospital. The sensitivity and specificity of various TB scoring cutoff points were assessed using a Receiver Operating Characteristic (ROC) curve. Additionally, the potential benefits of incorporating symptom duration into the scoring system were explored.
Results
The current TB scoring system, with a cutoff point of 4, demonstrated a sensitivity of 83% and a specificity of 53%. By increasing the cutoff point to 6, the sensitivity decreased to 79%, while the specificity increased to 67%. Incorporating symptom duration into the scoring system was identified as a potential factor for further enhancing its diagnostic performance.
Conclusion
The current TB scoring system can be improved by adjusting the cutoff point to achieve a better balance between sensitivity and specificity. A dynamic scoring approach that considers symptom duration may provide additional benefits in terms of diagnostic accuracy. Further research is needed to validate these findings and explore other factors that could refine the scoring system, ultimately enhancing its effectiveness in screening and managing TB cases.