bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumptive Hypothyroidism due to Hepatic Hemangiomas: A Case Series and Review of the Literature
Authors: Siano Maria Anna , Ametrano Orsola , Barbato Filomena , Sammarco Elena , Ranucci Giusy , Pietrobattista Andrea , Rossomando Alessia , Mandato Claudia 
Published: January 2023

Introduction:Consumptive hypothyroidism (CH) is a rare and potentially overlooked complication of hepatic hemangiomas (HH) overexpressing the enzyme deiodinase, which converts thyroxine (T4) to reverse triiodothyronine (rT3).Materials and methods:Here, we report a case series of 3 patients and a systematic review of the literature.Results:Hypothyroidism (mean serum TSH 52.03 mIU/L) was detected at a mean age of 4.6 months (range 3–6) in 3 infants with infantile hepatic hemangiomas, treated with thyroxine (mean dose 12 µg/kg/day). All received treatment with propranolol (1–3 mg/kg/day) from the mean age of 4 months. Hormonal treatment was stopped at a mean age of 20 months (range 12–30). Hypothyroidism reoccurred in a patient concurrently with the increase of liver lesions, requiring liver transplantation (LT) at age 39 months.Literature review retrieved 42 studies (48 patients): HH (n = 43) were isolated in 24 infants and associated with cutaneous hemangiomas in 19. Hemangiomas were only cutaneous in 5.In the first 43 patients, hypothyroidism was detected at a mean age of 1 month; 21 of 43 patients were prescribed propranolol alone (n = 8) or associated with other medicaments (n = 13); 2 of 43 patients underwent LT. Hormonal treatment consisted of T4 in 35 of 43 patients and T3 in 10.CH associated with only cutaneous and extrahepatic visceral hemangiomas (n = 5), detected at a mean age of 7 months (TSH mean levels at diagnosis of 150.3 mIU/L). Three of 5 patients received treatment with propranolol ± other medicaments. All 5 patients were treated with T4.Conclusions:Periodical thyroid function assessment is necessary in patients with hepatic hemangiomas, particularly when lesions’ size and number increase rapidly.
Complementary Role of 18F-Fluciclovine PET/CT and 18F-NaF PET/CT in Detecting Prostate Cancer Metastasis
Authors: Xu Feng , Liu Frank , Chen Wen 
Published: January 2023

Abstract
We present different findings on 18F-fluciclovine (Axumin) PET/CT and 18F-NaF PET/CT images in a patient with prostate cancer metastasis. 18F-Fluciclovine PET/CT scan showed intense uptake in left adrenal gland metastasis, only faint to mild uptake in multiple sclerotic osseous metastasis where 18F-NaF bone PET/CT demonstrated intense uptake at these sites. Both examinations are needed to accurately evaluate visceral and osseous metastasis from prostate cancer.
Chimeric Antigen Receptor T-Cell Therapy of Neurolymphomatosis Monitored by FDG PET/CT
Authors: Li Siqi , Wang Hongrong , Wang Guanyun , Lu Xia , Yang Jigang 
Published: January 2023

Abstract

18F-FDG PET/CT was performed to evaluate possible recurrent B-cell lymphoblastic lymphoma in a 34-year-old man. The images showed multiple foci of increased activity in the nerve root and peripheral nerve. A biopsy confirmed the diagnosis of neurolymphomatosis. After receiving chemotherapy, PET/CT showed progressive disease. The patient subsequently received the CD-19 chimeric antigen receptor T-cell therapy. A follow-up PET/CT acquired 30 days after chimeric antigen receptor T-cell therapy revealed no abnormal FDG activity.
Optimal Donor Allograft Function: The Search for the Lowest Acceptable Donor Left Ventricular Ejection Fraction in Pediatric Heart Transplantation
Authors: Masotti Elizabeth S. , Morrison John M. , Fierstein Jamie L. , Ashfaq Awais , Carapellucci Jennifer , Khalaf Racha , Laks Jessica A. , Miller Alexandra , Amankwah Ernest K. , Asante-Korang Alfred 
Published: January 2023

Background.
The availability of heart donors is limited by organ shortage. Due to concerns of reduced survival, donors with depressed left ventricular ejection fraction (LVEF <50%) have been cautiously used in pediatric heart transplantation. One strategy to expand the donor pool is to re-evaluate whether lower donor LVEF may be acceptable for transplantation.

Methods.
We performed a multicenter retrospective cohort study of patients <18 y receiving heart transplants from April 2007 to September 2021 using the United Network of Organ Sharing dataset. We excluded retransplants and multiorgan transplants. Cut-point analyses of LVEF was performed and Kaplan–Meier method was used to compare 1-y survival for new cut-points and the standard (LVEF >50%).

Results.
The analytic sample consisted of 5255 patients. Recipients receiving hearts with lower LVEFs were more likely to be on ventilator and extracorporeal membrane oxygenation support. Recipients did not differ in waitlist times or transplant status. Cut-point analysis identified LVEF 45% as a potentially new cutoff. One-year survival of recipients of donors with LVEF ≥45% (92.1%; 95% confidence interval [CI], 91.3%-92.8%) was similar to that of LVEF >50% (92.1%; CI, 91.4%-92.9%). Survival for the LVEF 45%–49% (88.8%; CI, 72.9%-95.7%) cohort was slightly lower than the ≥50% cohort, albeit nonsignificant.

Conclusions.
One-year survival among pediatric heart transplants using a donor heart LVEF threshold of 45% or 40% was similar to a threshold of 50%. However, the finding is based on a small number of patients with LVEF <50%, and future larger prospective studies are warranted to confirm the findings of this study before a lower LVEF threshold is considered.
Transition to chaos and modal structure of magnetized Taylor–Couette flow
Authors: Guseva A. , Tobias S. M. 
Published: January 2023

Taylor–Couette flow (TCF) is often used as a simplified model for complex rotating flows in the interior of stars and accretion discs. The flow dynamics in these objects is influenced by magnetic fields. For example, quasi-Keplerian flows in Taylor–Couette geometry become unstable to a travelling or standing wave in an external magnetic field if the fluid is conducting; there is an instability even when the flow is hydrodynamically stable. This magnetorotational instability leads to the development of chaotic states and, eventually, turbulence, when the cylinder rotation is sufficiently fast. The transition to turbulence in this flow can be complex, with the coexistence of parameter regions with spatio-temporal chaos and regions with quasi-periodic behaviour, involving one or two additional modulating frequencies. Although the unstable modes of a periodic flow can be identified with Floquet analysis, here we adopt a more flexible equation-free data-driven approach. We analyse the data from the transition to chaos in the magnetized TCF and identify the flow structures related to the modulating frequencies with dynamic mode decomposition; this method is based on approximating nonlinear dynamics with a linear infinite-dimensional Koopman operator. With the use of these structures, one can construct a nonlinear reduced model for the transition.This article is part of the theme issue ‘Taylor–Couette and related flows on the centennial of Taylor’s seminalPhilosophical Transactionspaper (part 1)’.
Exponential increase in QTL detection with increased sample size
Authors: Chitre Apurva S. , Polesskaya Oksana , Munro Daniel , Cheng Riyan , Mohammadi Pejman , Holl Katie , Gao Jianjun , Bimschleger Hannah , Martinez Angel Garcia , George Anthony , Gileta Alexander F. , Horvath Aidan , Hughson Alesa , Ishiwari Keita , King Christopher P. , Lamparelli Alexander , Versaggi Cassandra L. , Martin Connor , Pierre Celine L. St. , Tripi Jordan A. , Richards Jerry B. , Wang Tengfei , Chen Hao , Flagel Shelly B. , Meyer Paul , Robinson Terry E. , Solberg Woods Leah C. , Palmer Abraham A. 
Published: January 2023

AbstractPower analyses are often used to determine the number of animals required for a genome wide association analysis (GWAS). These analyses are typically intended to estimate the sample size needed for at least one locus to exceed a genome-wide significance threshold. A related question that is less commonly considered is the number of significant loci that will be discovered with a given sample size. We used simulations based on a real dataset that consisted of 3,173 male and female adult N/NIH heterogeneous stock (HS) rats to explore the relationship between sample size and the number of significant loci discovered. Our simulations examined the number of loci identified in sub-samples of the full dataset. The sub-sampling analysis was conducted for four traits with low (0.15 ± 0.03), medium (0.31 ± 0.03 and 0.36 ± 0.03) and high (0.46 ± 0.03) SNP-based heritabilities. For each trait, we sub-sampled the data 100 times at different sample sizes (500, 1,000, 1,500, 2,000, and 2,500). We observed an exponential increase in the number of significant loci with larger sample sizes. Our results are consistent with similar observations in human GWAS and imply that future rodent GWAS should use sample sizes that are significantly larger than those needed to obtain a single significant result.
SARS-CoV-2 Mproprotease variants of concern display altered viral and host target processing but retain potency towards antivirals
Authors: Chen Sizhu Amelia , Arutyunova Elena , Lu Jimmy , Khan Muhammad Bashir , Rut Wioletta , Zmudzinski Mikolaj , Shahbaz Shima , Iyyathurai Jegan , Moussa Eman , Turner Zoe , Bai Bing , Lamer Tess , Nieman James A. , Vederas John C. , Julien Olivier , Drag Marcin , Elahi Shokrollah , Young Howard S. , Lemieux M. Joanne 
Published: January 2023

ABSTRACTMain protease of SARS-CoV-2 (Mpro) is the most promising drug target against coronaviruses due to its essential role in virus replication. With newly emerging variants there is a concern that mutations in Mpromay alter structural and functional properties of protease and subsequently the potency of existing and potential antivirals. We explored the effect of 31 mutations belonging to 5 variants of concern (VOC) on catalytic parameters and substrate specificity, which revealed changes in substrate binding and rate of cleavage of a viral peptide. Crystal structures of 11 Mpromutants provided structural insight into their altered functionality. Additionally, we show Mpromutations influence proteolysis of an immunomodulatory host protein Galectin-8 (Gal-8) and subsequent significant decrease in cytokine secretion, providing evidence for alterations in escape of host-antiviral mechanisms. Accordingly, mutations associated with the highly virulent Delta VOC resulted in significant increase in Gal-8 cleavage. Importantly, IC50s of nirmatrelvir (Pfizer) and our irreversible inhibitor AVI-8053 demonstrated no changes in potency for both drugs for all mutants, suggesting Mprowill remain a high-priority antiviral drug candidate as SARS-CoV-2 evolves.
EB1 decoration of microtubule lattice facilitates spindle-kinetochore lateral attachment inPlasmodiummale gametogenesis
Authors: Yang Shuzhen , Cai Mengya , Huang Junjie , Zhang Shengnan , Mo Xiaoli , Jiang Kai , Cui Huiting , Yuan Jing 
Published: January 2023

AbstractFaithful chromosome segregation of 8 duplicated haploid genomes into 8 daughter male gametes is essential for male gametogenesis and mosquito transmission ofPlasmodium. Plasmodiumevolves the endomitosis for this multinucleated cell division. However, the mechanism underlying the spindle-kinetochore attachment remains elusive. End-binding proteins (EBs) are the conserved microtubule (MT) plus-end binding proteins and play an important role in regulating MT plus-end dynamics. Here we report thatPlasmodiumEB1 is a unique orthologue distinct from the canonical eukaryotic EB1. Bothin vitroandin vivoassays revealed thatPlasmodiumEB1 lost MT plus-end tracking but gained MT-lattice affinity. This MT-binding feature of EB1 is contributed by both the CH domain and the linker region. EB1-deficient parasites produce male gametocytes that develop to the anucleated male gametes, leading to defective mosquito transmission of parasite. EB1 is localized at the nucleoplasm of male gametocytes. Upon gametogenesis, EB1 decorates the full-length of spindle MTs and regulates spindle structure. The kinetochores attach to spindle MTs laterally throughout three rounds of endomitosis and this attachment is EB1-dependent. Consequently, impaired spindle-kinetochore attachment was observed in EB1-deficient parasites. These results indicate that a parasite-specific EB1 with MT-lattice affinity has evolved to fulfill the spindle-kinetochore lateral attachment in male gametogenesis.
Development of a Data-driven Integrative Model of Bacterial Chromosome
Authors: Wasim Abdul , Bera Palash , Mondal Jagannath 
Published: January 2023

AbstractThe chromosome of archetypal bacteriaE. coliis known for a complex topology with 4.6 × 106base pairs (bp) long sequence of nucleotide packed within a micrometer-sized celllular confinement. The inherent organization underlying this chromosome eludes general consensus due to the lack of a high-resolution picture of its conformation. Here we present our development of an integrative model ofE. coliat a 500 bp resolution (https://github.com/JMLab-tifrh/ecoli_finer), which optimally combines a set of multi-resolution genome-wide experimentally measured data within a framework of polymer based architecture. In particular the model is informed with intra-genome contact probability map at 5000 bp resolution derived via Hi-C experiment and RNA-sequencing data at 500 bp resolution. Via dynamical simulations, this data-driven polymer based model generates appropriate conformational ensemble commensurate with chromosome architectures thatE. coliadopts. As a key hallmark, the model chromosome spontaneously self-organizes into a set of non-overlapping macrodomains and suitably locates plectonemic loops near the cell membrane. As novel extensions, it predicts a contact probability map simulated at a higher resolution than precedent experiments and can demonstrate segregation of chromosomes in a partially replicating cell. Finally, the modular nature of the model helps us to devise control simulations to quantify the individual role of key features in hierarchical organization of the bacterial chromosome.
Southern Africa Trust: embarking on a sustainability journey
Authors: Mogotsi Keratiloe , Moyo Bhekinkosi , Urban Angie 
Published: January 2023

Learning outcomes
The learning outcomes focus on enabling students to view operational model changes critically, as they pertain to:
■ evaluating different management styles and uses of the ADKAR change management model in decision-making moments in times of crisis (such as COVID-19) in non-profit organisations (NPOs);
■ evaluating different ways in which NPOs pivot to sustainability, including the use of social enterprise models and change management;
■ anticipating and managing change in institutional formations through new technologies;
■ articulating trade-offs between grant and non-grant resource mobilisation for African philanthropy; and
■ application of change management theory to organisations’ sustainability journeys.

Case overview/synopsis
In May 2020, working from her home office just over one month into a nationwide lockdown because of the COVID-19 pandemic, Masego Madzwamuse, chief executive officer (CEO) of the Southern Africa Trust (the Trust), knew that it could once again be at a crossroads. In 2015, the Trust had found itself in a quandary when its primary donor gave notification of its intention to withdraw its funding. The Trust had responded by making changes to its structure and strategy. Now, with uncertainty rife throughout South Africa, the CEO knew that she had to consider whether the changes that had been implemented over the past five years had prepared the Trust not only to respond to, but also to survive the pandemic and continue its vital work long into the future.

Complexity academic level
Postgraduate Diploma in Management, MBA, Masters in Management.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 11: Strategy.
B2B value co-creation influence on engagement: Twitter analysis at international trade show organizer
Authors: Geldres-Weiss Skania , Küster-Boluda Inés , Vila-López Natalia 
Published: January 2023

PurposeThis paper studies, based on the theory of service-dominant logic, the effect of value co-creation practices (linking and materializing) on engagement dimensions (popularity, commitment and virality). The main objective is to analyze the influence of value co-creation practices on engagement at international trade shows organizer association on Twitter.Design/methodology/approachThis paper studies the usage of Twitter by the Specialty Food Association, which organizes one of the top five foods and beverage international trade show in the United States. To achieve the research objective, the authors have analyzed 1,608 posts on Twitter from the Twitter account @Specialty_Food. A content analysis was performed using Krippendorff's (2004) recommendations, and the data were analyzed using regression analysis with optimal scaling and Kruskal–Wallis Test.FindingsAccording to the results, some materializing practices influence popularity, commitment, virality and global engagement on Twitter. While the usage of some linking practices influences respectively commitment and popularity.OriginalityThese results provide valuable information for business-to-business (B2B) contexts and answer a research gap reported in previous literature, which affirms that more research is needed about the relationship between service systems and engagement. From a general view, to generate more engagement on social media in B2B contexts, it is recommended to prioritize posts that incorporate live and online events based on collaborative and dynamic human interactions, following by business ideas and business cases.
Analysing public diplomacy on Twitter with the MARPE Diplo methodological framework: the case of the European external action service
Authors: Cotton Anne-Marie , Boulanger Hélène 
Published: January 2023

PurposeThe European External Action Service (EEAS) is a relatively new diplomatic service established in 2010. In previous analyses, the authors noted a dominance of security and foreign policy messages emanating from the EEAS, demonstrating the European Union (EU)'s negotiating power. It was clear it had discovered the benefits of public diplomacy, but rather practised traditional diplomacy on public diplomacy specific platforms. The authors aim to pursue the monitoring of the EEAS’ strategy, covering 2019 and 2020, to understand how the use of Twitter supports the evolution of the EU foreign policy.Design/methodology/approachQuestioning if the EEAS is entering the second phase of its life cycle (launched in 2010, its introduction phase was under Katherine Ashton, 2009–2014, followed by Federica Mogherini, 2014–2019, and Josep Borrell, 2019–2024), the authors carried out a content analysis on 765 tweets. The authors used the MARPE Diplo methodological framework to compare how the EU uses public diplomacy through its EEAS to negotiate its own interests with non-EU parties under the presidency of Federica Mogherini (period 1), during the transition period (period 2) and under the presidency of Joseph Borrell (period 3).FindingsBased on the comparison with their previous studies, the authors demonstrate that, over the years, the overall discourse of the EEAS is much more oriented towards public diplomacy.Research limitations/implicationsThe present study has two limitations. The first refers to the sampling of the participants involved in the citizen science experiment: they belong to a homogeneous age category and similar education level which might have biased their analysis. Second, the authors acknowledge the usual limitations linked to citizen science. However, the authors acknowledge a growing emphasis on the outcomes for society involving citizens and including partnerships between the public and scientists as well as an increased public engagement in policy processes.Practical implicationsThe research leads into new insights regarding the European-centred translation of the EEAS messages, compared to the off-centred view of non-European contributors.Social implicationsThe citizen science approach allows to integrate the targeted public to apply public diplomacy content analysis.Originality/valueThis case study is based on the principles of citizen science and demonstrates the importance of an off-centred approach in the analysis of the practices of public diplomacy.
“I am not a typical woman. I don’t think I am a role model” – Blokishness, behavioural and leadership styles and role models
Authors: Topić Martina 
Published: January 2023

PurposeThis paper presents a sociological analysis of the advertising industry's leadership styles and role models in England using masculinities in behaviour (“blokishness”) as a concept. The paper particularly focusses on the experiences of the so-called tomboy women who were socialised with boys and embraced masculine behavioural styles and compares their views and styles with women who experienced a more common, feminine socialisation and spent time in girls' peer groups during early socialisation. The paper explores why some women are seen as role models and others are not.Design/methodology/approachQualitative interviews were conducted with 37 women working in a variety of roles within the advertising industry in England, and from a variety of backgrounds, and views on leadership and role models were analysed with a particular focus on “tomboy” women and their behavioural and leadership styles, which is linked with role models and compared against views of the so-called feminine women. Triple coding and a thematic analysis were used to analyse data and make sense of concepts derived from participants' answers.FindingsThe findings suggest that tomboy women demonstrate masculine leadership and behavioural styles and are less likely to see themselves as role models along with facing disapproval from female employees they manage. On the other hand, feminine women demonstrate feminine leadership styles and are more likely to see themselves and become accepted as role models. Thus, the paper suggests that the perception and experience of role models depend on behavioural and leadership styles, which is different for the so-called tomboy and feminine women. Data suggest this is due to participation in early peer groups during childhood. The paper offers conceptualisation figures to inform future research.Practical implicationsThe findings suggest it is not always formal structure that impedes the progress of women, but often informal ones linked to behavioural styles. Therefore, whilst many positive policies have been introduced to improve equality in organisations and society in general, this paper sheds light on how these policies could get undermined by informal issues such as behavioural and leadership styles. Human resource (HR) professionals should further internal policies to prevent situations in which only those “who are like us” can go ahead in their careers by diversifying the workforce and employment and promotions panels.Originality/valueTo the best of the author's knowledge, this is the first paper analysing role models, and leadership styles linked to the position of women in the advertising industry, focussing on blokishness in behaviour and comparing styles of the so-called tomboy and feminine women.