bluuebunny/crossref_metadata_2025_split huggingface dataset:
The causal role of circulating amino acids on neurodegenerative disorders: A two‐sample Mendelian randomization study
Authors: Cheng Ji‐Yun , Deng Yue‐Ting , Yu Jin‐Tai 
Published: August 2023

AbstractPotential associations between the risk of neurodegenerative diseases and circulating levels of amino acids have been implied in both experimental research and observational studies. However, because of the confounding and reverse causality, the findings could be biased. We aimed to determine whether circulating amino acid levels have potential effects on the risk of neurodegenerative diseases through a more robust analysis. So, we performed a total of two MR analyses, a discovery two‐sample MR analysis, and a replication test, using summary‐level genome‐wide association study (GWAS) data, both with circulating levels of amino acids as exposure and risk of neurodegenerative diseases as an outcome. The potential causalities between nine amino acids (Glutamine [Glu], Leucine [Leu], Isoleucine [Ile], Phenylalanine [Phe], Valine [Val], Alanine [Ala], Tyrosine [Tyr], Histidine [His], and Glycine [Gly]) and six neurodegenerative disorders (Alzheimer's disease [AD], Parkinson's disease [PD], Multiple sclerosis [MS], Frontotemporal dementia [FTD], Lewy body dementia [DLB], Amyotrophic lateral sclerosis [ALS]) were explored in this study. According to the discovery MR analysis, 1 SD. increase in circulating levels of Gln was genetically determined to result in a 13% lower risk of AD (IVW ORSD [95% CI] = 0.872 [0.822, 0.926]; FDR = 7.46 × 10−5) while PD risk was decreased to 63% per SD. increase of circulating Leu levels (IVW ORSD [95% CI] = 0.628 [0.467, 0.843]; FDR = 0.021). Results from the replication test provide further evidence of the potential association between circulating Gln levels and AD risk (IVW ORSD [95% CI] = 0.094 [0.028, 0.311]; FDR = 9.98 × 10−4). Meanwhile, sensitivity analysis demonstrated that the significant relationships revealed by our two‐sample MR outcomes were reliable. Our analyses provided robust evidence of causal associations between circulating levels of Gln and AD risk as well as circulating Leu levels and risk of PD. However, the underlying mechanisms remain to be further investigated.image
Does the articularis cubiti muscle really exist? Anatomical, histological, and magnetic resonance imaging study with a narrative review of literature
Authors: Benes Michal , Novotny Tomas , Kachlik David , Uhlik Jiri , Kunc Vojtech 
Published: August 2023

AbstractAlthough the term articularis cubiti muscle is incorporated in the official anatomical nomenclature, only sparse data about its appearance are available. It is usually described as few fibres originating from the medial head of the triceps brachii muscle and inserting to the capsule of the elbow joint. However, the most recent observations regarding the morphological relations in the posterior elbow region point towards the absence of a well‐defined muscle. Therefore, this study was designed to verify the existence of the articularis cubiti muscle in question and to compile more data on the topographical features of the subtricipital area near the posterior aspect of the elbow. To address these questions, 20 embalmed upper limbs were dissected, and seven samples were collected for histological analysis. The laboratory findings were then correlated with 20 magnetic resonance imaging (MRI) scans of the elbow. Consequently, a narrative review of literature was performed to gain more information on the discussed muscle in a historical context. Upon the anatomical dissection, muscular fibres running from the posterior aspect of the shaft of the humerus to the elbow joint capsule and olecranon were identified in 100% of cases. Histologically, the connection with the joint capsule was provided via winding bands of connective tissue. On MRIs, the muscular fibres resembled a well‐demarcated thin muscle located underneath the medial head of the triceps brachii muscle. Combined with the review of literature, we concluded that the constant articularis cubiti muscle originates from the posterior shaft of the humerus and attaches indirectly to the posterior aspect of the elbow joint capsule and directly to the superior portion of the olecranon. The obtained results slightly differ from the modern description, but are in agreement with the original publication, which has become misinterpreted throughout time. Presumably, the misused description has led to questioning the existence of an independent muscle. Moreover, our findings attribute to the articularis cubiti muscle, a function in pulling on the posterior aspect of the elbow joint capsule to prevent its entrapment, and possibly also a minor role in extension of the forearm. The presented results should be taken into consideration when intervening with the posterior aspect of the elbow joint because the articularis cubiti muscle poses a consistently appearing landmark.
Centella triterpenes cream as a potential drug for the treatment of hypertrophic scar through inhibiting the phosphorylation of STAT3: A network pharmacology analysis and in vitro experiments
Authors: Tan Ming , Wu Dan , Zhou Yanshijing , Duan Bo 
Published: August 2023

AbstractBackgroundHypertrophic scars (HS) often affect the normal function and appearance of the skin and bring adverse effects to the body and mind of patients, being a challenge in the fields of burns and plastic surgery as well as rehabilitation. Despite significant efficacy of centella triterpenes cream for treating HS clinically, its pharmacodynamics and molecular targets are still unclear. Therefore, the network pharmacology analysis combined with in vitro cell molecular biology experiments was used to explore the mechanism and targets of centella triterpenes cream treating HS in this study.MethodsFirst, target genes of asiaticoside (AC) were obtained from the databases including the Comparative Toxicogenomics Database, similarity ensemble approach, SwissTargetPrediction and TargetNet, and HS targets were acquired from the databases like Disgenet, GeneCards, and Online Mendelian Inheritance in Man. The common targets of AC‐HS were obtained through plotting a Venn diagram. Subsequently, STRING 11.0 was employed for analyzing the protein–protein interaction (PPI) network of the common targets, and cytoscape 3.9.0 for analyzing the connectivity of PPI and plotting the network diagram of “drug‐component‐target”. Additionally, a modified tissue culture method was applied to separate primary normal fibroblasts (NFs) in human skin and hypertrophic scar fibroblasts (HSFs). HSFs after 24‐h AC treatment were subjected to MTT assay to detect cell viability, scratch assay to assess cell migration ability, and western blot to test the protein expression levels of STAT3, p‐STAT3, transforming growth factor‐β1 (TGF‐β1), collagen I (COL 1), fibronectin 1 (FN1), and alpha‐smooth muscle actin (α‐SMA).ResultsIn network pharmacology analysis, 134 pharmacodynamic targets of AC and 2333 HS targets were obtained after retrieving the database, 50 AC‐HS common targets were obtained by a Venn diagram, and a total of 178 edges and 13 core genes such as JUN and STAT3 were acquired by PPI analysis. In vitro experiments showed that the phosphorylation level of STAT3 (p‐STAT3) was increased in HSFs. In addition to reducing p‐STAT3 in HSFs, AC significantly inhibited the cell viability and migration of HSFs and downregulated the protein levels of TGF‐β1, COL 1, FN 1, and α‐SMA.ConclusionSTAT3 can be activated in HS. AC may exert its pharmacological effects of inhibiting TGF‐β1 signal transduction and regulating extracellular matrix remodeling in HS by inhibiting STAT3 phosphorylation. However, the specific molecular mechanism of AC remains to be verified through further experiments.
Emotion‐Driven Eating and Overeating Among Fourth Graders: The Roles of Body Image, Academic Achievement, and Peer and School Factors
Authors: Somers Cheryl , Kevern Carla , Moore E. Whitney G. , Centeio Erin E. , Kulik Noel , Piotter Bridget , Garn Alex , McCaughtry Nate 
Published: August 2023

ABSTRACTBACKGROUNDEating patterns such as breakfast consumption and fruit and vegetable intake have been associated with academic achievement and cognitive function.METHODThe purpose of this study was to learn more about psychological (emotion‐driven eating) and behavioral (over‐eating) eating patterns and motives, and the roles of body image, academic achievement (reading and math), and social supports (peer acceptance and school attachment), among 378 fourth‐grade students (55% boys) from 14 classrooms across 6 schools within a large Midwestern urban area.RESULTSResults were analyzed through a 2‐group (male and female) path analysis. Boys' overeating (R2 = 9%) was not significantly predicted. Their emotional eating (R2 = 22.2%) was negatively, significantly predicted by peer acceptance and interaction of peer acceptance and school attachment. Girls' overeating (R2 = 13.6%) was negatively, significantly predicted by positive body image. Girls' emotional eating (R2 = 24.1%) was negatively significantly predicted by positive body image, math scores, and peer acceptance.CONCLUSIONSBoys' and girls' eating patterns are differentially affected by their school experiences.
The Quality of Life Supports Model as a major component in applying the quality of life paradigm
Authors: Verdugo Miguel Ángel , Schalock Robert L. , Gómez Laura E. 
Published: August 2023

AbstractSocial change is built on paradigms and models. A paradigm needs an operational action model to successfully implement the paradigm, and an operational model needs a paradigm to give it credibility and content. This article describes the Quality of Life Supports Model (QOLSM) as a major pathway for applying the quality of life (QOL) paradigm. The QOLSM integrates the concepts of QOL and individualized supports. The article describes and illustrates: (a) the four elements of the QOLSM (core values, individual and family QOL domains, systems of supports, and facilitating conditions); and (b) the use of the QOLSM in the field of intellectual and developmental disabilities (IDDs) as a framework for supports provision. The article also discusses how the QOLSM represents a value‐based and actionable model that should be effective for solving problems regarding services and supports to people with IDD, developing new knowledge, making meaningful change, being evaluated, and contributing both theoretically and operationally to the field.
Clinical characterisation and long‐term survival of paediatric and juvenile lymphoma in cats: 33 cases (2008‐2022)
Authors: Rogato F. , Tanis J. B. , Pons Gil B. , Pittaway C. , Johnston C. A. , Guillén A. 
Published: August 2023

ObjectivesThe aims of this study were to describe the clinical presentation, tumour characteristics, responses to chemotherapy protocols and toxicity in a cohort of cats with lymphoma up to 18 months of age. In addition, the probability of long‐term (>2 years) survival was explored.Materials and MethodsThe medical records of client‐owned cats aged up to 18 months diagnosed with lymphoma between 2008 and 2022 at five UK‐based veterinary referral hospitals were reviewed.ResultsThirty‐three cats were included. The most common anatomical forms were mediastinal (42%), disseminated disease (30%) and renal (15%), with all cats having intermediate to large cell lymphoma. Three out of 29 cats tested were positive for FeLV but none for FIV. Twenty‐six cats were treated with multi‐agent chemotherapy protocols with complete and partial responses seen in 46% and 50% of cats, respectively. For this group, median progression‐free survival was 133 days (95% confidence interval [Cl] 67 to 199) and median survival time was 268 days (95% Cl 106 to 430). Complete response to chemotherapy was associated with a longer progression‐free survival. Seven cats were considered long‐term survivors (>2 years). Chemotherapy was generally well tolerated with none of the long‐term survivors suffering from chronic sequelae from cytotoxic treatment.Clinical SignificancePaediatric and juvenile cats with lymphoma showed a high response rate to multi‐agent chemotherapy protocols with rare significant toxicities. The presence of long‐term survivors may suggest a more favourable outcome in a subset of patients.
Seasonality and meteorological factors of HIV‐negative cryptococcal meningitis in Guangdong Province, China
Authors: Dai Kai , Feng Zhuo , Hu Tao , Su Zhihui , Yuan Dasen , Qin Bang‐e , Gu Meifeng , Peng Fuhua , Jiang Ying 
Published: August 2023

AbstractObjectiveInformation about the seasonal characteristics of human immunodeficiency virus (HIV)‐negative cryptococcal meningitis (CM) is quite limited. The aim of this study was to explore the seasonality and meteorological factors of HIV‐negative patients with CM.MethodsWe performed a retrospective study of 469 HIV‐negative CM patients admitted to the Third Affiliated Hospital of Sun Yat‐sen University, Guangzhou, Guangdong Province, China. Their initial onset symptoms of CM occurred from January 2011 to December 2020. The temperature, precipitation, sunlight, humidity and wind speed for the corresponding period and the associated topographic, ecological type and soil type parameters data were collected. The Poisson regression model was used to determine the meteorological factors associated with CM onset. The geographical detector method was used to detect other environmental factors associated with CM onset.ResultsCM onset did not showed a seasonal fluctuation, but was strongly associated with mean temperature (β = .010, p = .028) and mean relative humidity (β = −.011, p = .006). In the rainy season, only mean wind speed remained significantly associated with CM onset (β = −.108, p = .041). In the dry season, mean temperature (β = .014, p = .016), mean relative humidity (β = −.016, p = .006) and hours of sunlight (β = −.002, p = .016) were significantly associated with CM onset. Topographic, ecological type and soil type factors did not add explanatory power.ConclusionsOur findings add the knowledge about the environmental factors of HIV‐negative CM. Meteorological factors, especially temperature and humidity, may be the main environmental factors affecting the onset of HIV‐negative CM.
Influence of family strength on life satisfaction of individuals who have a sibling with disability: Mediating effect of disability acceptance
Authors: Yoo Hye Jin , Lee Hyeongsuk 
Published: August 2023

AbstractThis descriptive correlational study was conducted to examine the mediating effect of disability acceptance on the relationship between family strength and life satisfaction in individuals who have a sibling with a disability. The responses of 144 non‐disabled siblings of persons with a disability were analyzed using panel data from the Korea Institute for Persons with Disabilities, and a regression analysis was performed. Family strength and acceptance of disabilities significantly affected the life satisfaction of siblings without disability. Regarding the effect of family strength on life satisfaction, acceptance of a sibling's disability by siblings without disability had a significant mediating effect. Our results suggest that strategies to enhance the acceptance of disabilities and promote family strength are necessary to improve the life satisfaction of individuals without disability as well as their siblings with disabilities. Family‐centered interventions are warranted to promote positive acceptance of disabilities.
Mapping the clinical care pathways for advanced stage non‐small cell lung cancer patients in Victoria: A retrospective cohort study of supportive and palliative care
Authors: Smith Shantelle , Sapkaroski Daniel , Brand Margaret , Tran Anh , Zalcberg John , Stirling Robert G. 
Published: August 2023

AbstractThe lung cancer Optimal Care Pathway recommends supportive care and palliative care integration throughout its various steps, with early referral to appropriate services improving the quality of life in advanced stage non‐small cell lung cancer patients. Using Victorian Lung Cancer Registry data and linked administrative datasets, this retrospective cohort study mapped clinical care pathways of 525 Stage III–IV non‐small cell lung cancer patients in Victoria to 11 recommendations in the Optimal Care Pathway, identifying unwarranted variations in clinical care. Supportive care and palliative care delivery were further examined to understand the involvement and timing of specialist care teams. Our findings showed that palliative care utilization is highest at the time of treatment, despite recommendations that it should be provided early after diagnosis to improve patient outcomes and satisfaction. Early supportive care screening was observed in half the cohort and almost three‐quarters of the patients had been presented at a multidisciplinary meeting. Multidisciplinary meeting presentations and supportive care provide an opportunity to improve communication about palliative care needs and integration into routine clinical practice, such as at the time of treatment planning.
Healthcare staff's experiences of using manual physical restraint: A meta‐synthesis review
Authors: Kodua Michael , Duxbury Joy , Eboh Winifred Oluchukwu , Asztalos Lilla , Tweneboa Justin 
Published: August 2023

AbstractManual restraint is a hands‐on type of physical restraint used to prevent harm to service users and staff, and to administer necessary treatments. This article reports on a review and meta‐synthesis of the qualitative literature on healthcare staff's experiences of using manual restraint. Three electronic databases (CINAHL Complete, MEDLINE, and PsycINFO) were systematically searched, and 19 studies were included. Thematic synthesis was used to synthesize the findings. The Critical Appraisal Skills Programme (CASP) checklist was used to appraise study quality. The synthesis generated one overarching interpretive theme, “unpleasant but necessary,” and five subthemes: “maintaining safety triumphs all,” “emotional distress,” “significance of coping,” “feeling conflicted,” and “depletion.” Seven studies indicated that, from staff perspectives, manual restraint was not always used as a last resort. Healthcare staff experience manual restraint as a psychologically and physically unpleasant practice, yet paradoxically deem its use to be sometimes necessary to keep themselves and service users safe from harm. The findings indicate a need for healthcare staff support, post‐restraint debriefing meetings with service users, and the implementation of manual restraint minimization programs in healthcare settings.
Technology: A metaparadigm concept of nursing
Authors: Bayuo Jonathan , Abu‐Odah Hammoda , Su Jing Jing , Aziato Lydia 
Published: August 2023

AbstractUndoubtedly, technology continues to permeate the world at an unprecedented pace. The discipline of nursing is not alien to this phenomenon as nurses continue to employ various technological objects and applications in clinical practice, education, administration and research. Despite the centrality of technology in nursing, it has not been recognised as a metaparadigm domain of interest in the discipline of nursing. Thus, this paper sought to examine if technology truly reflected a metaparadigm domain using the four requirements posited by Fawcett. Using these requirements, we examined the onto‐epistemology of technology in relation to nursing and conclude that technology potentially represents a distinct domain that intersects with nursing (particularly, from the humanities perspective). Also, technology encompasses some phenomena of interest to the discipline of nursing, demonstrates perspective‐neutrality, and is international in scope and substance albeit with some nuances which do not fit well with nursing onto‐epistemology. Put together, it is highlighted that technology intersects with the existing metaparadigm domains (person, health, environment and nursing) which positions it as a potential phenomenon of interest to the discipline of nursing requiring further work to articulate its position and role.
Apical incisor root resorption due to ectopic maxillary canine eruption: Association with time of diagnosis and type of intervention in a retrospective population‐based cohort study
Authors: Botticelli Susanna , Byriel Tina , Stoustrup Peter , Cattaneo Paolo Maria , Küseler Annelise 
Published: August 2023

AbstractObjectivesThe primary aim was to study upper incisor severe apical root resorption (RR) related to ectopic canine eruption and its association with timing of diagnosis and type of intervention conducted. The secondary aim was to correlate resorption with other dental anomalies.Materials and MethodsDigital journals and radiographic material of all ectopic maxillary canines registered in 2012 in the regional public paediatric dental clinics in the Council of Aarhus were inspected retrospectively. Data related to 10 variables were retrieved. Post‐treatment radiographs were used for evaluation of incisor RR.ResultsA total of 260 ectopic maxillary canines were diagnosed in 2012. The majority were found in the 9‐13‐year‐old age group (0.8% prevalence within the total population). In all, 244 canines were assessed for eligibility and 181 had adequate final radiographs for evaluation of RR. Among ectopic maxillary canines, 9.4% caused severe incisor RR to neighbouring teeth. Timely palpation for canine eruption significantly reduced the odds for upper incisor resorption by 80%. Multiple regression showed that when the permanent canine cannot be palpated and the deciduous has been extracted, delaying the first X‐rays was associated with a 38% odds ratio increase for RR for each year of delay after the age of 10 years. No significant associations were found between incisor RR and intervention conducted or other dental anomalies.ConclusionPalpation of erupting maxillary canines is crucial for timely diagnosis of ectopic eruption and initiation of treatment to avoid RR. If the canine cannot be palpated at 10 years of age, radiographic examination is highly recommendable.