bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemorrhagic complications during stereotactic biopsy of brain tumors
Authors: Kukanov K. K. , Voinov N. E. , Peskov V. A. , Ulitin A. Yu. , Dikonenko M. V. 
Published: July 2023

Relevance. Stereotactic biopsy (STB) is one of the main methods for diagnosing deep brain lesions. STB has several advantages over conventional intraoperative biopsy, as it is less traumatic and safer, especially for patients in critical condition. However, the most common complications of STB are hemorrhages, with a risk ranging from 0.9 % to 59.8 % depending on various studies. Intracranial hemorrhages are serious complications of surgical treatment of brain tumors, especially during biopsy using stereotactic techniques.Objective. To assess the risk of intracranial hemorrhages during STB of brain tumors and investigate possible factors influencing this risk, such as involvement of different brain regions in the neoplastic process, patient’s gender and age, degree of malignancy of the tumor, and use of different stereotactic devices.Materials and Methods. A retrospective study of data from 20 patients who underwent STB of brain tumors was conducted. Clinical data, examination results including coagulogram and aggregatogram, as well as data on involvement of different anatomical brain regions in the neoplastic process, degree of malignancy of the tumor, and use of a specific stereotactic device were analyzed.Results. Analysis of the frequency and structure of hemorrhagic complications of STB was performed, prognostic factors for high risk were identified, and preventive measures were proposed to reduce the number of hemorrhages.Conclusions. The introduction of the modern CRW Radionics stereotactic device into practice has reduced the frequency and severity of hemorrhagic complications after STB by two times. Lymphoproliferative processes and glioblastomas have a higher frequency of hemorrhages, but in most cases, they are clinically insignificant. There is a correlation between the degree of anaplasia of astrocytic tumors and the severity of hemorrhages. Ways to reduce the risks of intracranial hemorrhages during STB of brain tumors may include: careful preoperative planning of the biopsy trajectory; use of informative neurovisualization methods in planning the needle insertion trajectory; use of modern stereotactic systems by neurosurgeons who have undergone additional specialization and training on the specific device; use of modern biopsy needles. In addition, it is advisable to consider preoperative preventive hemostatic therapy in patients suspected of having a high degree of tumor anaplasia.
RATIONALE FOR SELECTING SAND FILTERS FOR PRODUCTION WELLS
Authors: Khabibullin Marat Ya. , Khabibullin Arsen M. 
Published: July 2023

Link for citation: Khabibullin M.Ya., Khabibullin A.M. Rationale for selecting sand filters for production wells. Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2023, vol. 334, no. 7, рр. 26-34. In Rus.
The relevance of the study are caused by the need to ensure the flow of more purified reservoir fluid into the bottomhole zone of the well. When opening a formation with production wells, the design of which includes anti-sand filters, there are some imperfections that are characterized by the degree and nature of its opening and are caused by the designs of casing filters. For a rational choice of an anti-sand filter in a well, it is necessary to conduct experimental bench studies, taking into account well conditions. Purpose: based on the results of experimental studies, propose the optimal design of the anti-sand filter. To select, it is necessary to take into account the hydraulic parameters of its operation, which can be determined based on the bench tests of two types of filter elements: block and frame-rod with wire winding, in open and cased hole conditions, as the most promising in terms of application. Objects. To accomplish this task, a stand was created that allows you to: determine the amount of fluid passing through with sand; the volume and granulometric state of the sands that pass through the filters when filtering the mixed liquid; state and change in the structure of rocks in the bottomhole zone of the well; distances between the filter elements and the production casing, the performance of the sand filter. The main component of the stand is a combined-shaped filtration tray imitating a circular reservoir model. Methods. The working fluid (oil), preheated to a predetermined temperature with the help of a heating element, is supplied to the filtration tray by a pump from the receiving tank through the pressure manifold. The temperature of the working fluid in a given mode is maintained using a non-contact controller. The discharge pressure is measured with a manometer. The pressure manifold is fitted with a spring-loaded relief valve. The change in pressure of the radial flow of the working fluid in the filtration tray is recorded by a pressure sensor. The working fluid from the filtration tray is passed through a cleaning system made in the form of two cylinders, in which there are sieves for trapping and screening sand particles with a size of 0,005 mm or more. The purified working fluid again enters the receiving tank. Results. Block and single-layer wire filters while ensuring a small amount of sand are quickly clogged. The double layer wire filter has the highest peak resistances and occasional significant sand production. Obviously, it can be recommended for flowing oil production, with a significant excess of reservoir pressure in relation to hydrostatic pressure.
Predicting intention to adopt omnichannel retailing of SMEs in Indonesia using UTAUT: the moderating role of personal innovativeness
Authors: Syahreza Alvin Erzal , Wahdiyat Moko  , Mintarti Rahayu  
Published: July 2023

This study seeks to explain the intent of SMEs business owners to implement omnichannel retail in their operations. This study employs the UTAUT model and adds innovativeness as a variable that can influence the intention to adopt an omnichannel. The sample for this research consisted of 90 SMEs proprietors in Malang City. This study's data were gathered via a questionnaire and analyzed using PLS-SEM. This study found that personal innovativeness and performance expectations significantly influence the intention to adopt omnichannel. In this study, effort expectations have no significant effect on the intention to implement omnichannel. It has been demonstrated that personal innovativeness can moderate the relationship between effort and performance expectations in the UTAUT model when it comes to the intention of MSME proprietors to implement omnichannel. In addition to focusing on consumers as end users, this study concludes that omnichannel service providers must also consider enterprises as omnichannel users.
Biomarkers in assessing the vulnerability of atherosclerotic plaques: a narrative review
Authors: Kovalskaya A. N. , Duplyakov D. V. 
Published: July 2023

Aim. To study the role of biomarkers in assessing the vulnerability of atherosclerotic plaques.Material and methods. A review of literature sources investigating the biomarker assessment of the vulnerability of atherosclerotic plaques published for the period 01.01.2016 to 31.12.2022 was carried out. Literature search was carried out in English and Russian in PubMed databases, in Google Academy, Elibrary.ru according to the following keywords: “biomarkers of plaque vulnerability”, “NLR and vulnerable plaque”, “CRP and vulnerable plaque”, ”MMP-9 and vulnerable plaque”, “TIMP-1 and vulnerable plaque”, ”galectin-3 and vulnerable plaque”, “NGAL and vulnerable plaque”. A total of 183 articles were found, of which 42 articles in full-text format containing original clinical studies were selected for the preparation of this review.Results. Numerous studies have shown that the vulnerability and rupture of the plaque, rather than its size and severity of stenosis, are the main cause of cardiovascular events in patients with coronary heart disease. Small plaques rich in lipids often become unstable due to an inflammatory reaction supported by the interaction between lipoproteins, monocytes, macrophages, T-lymphocytes and vascular wall cells. NLR, CRP, NGAL, Galectin-3, as well as markers of extracellular matrix degradation (MMP-9, TIMP-1) can play a special role in assessing the vulnerability of plaques.Conclusion. The development of acute coronary syndrome is based on the destabilization of the atherosclerotic plaque, which occurs not only due to changes in its lipid composition, but also infiltration by immuno-inflammatory cells, degradation of the extracellular matrix, as well as an active inflammatory reaction and neovascularization of the plaque. Therefore, traditional imaging methods that characterize the plaque by its appearance and size are not enough to predict the risk of rupture and the development of an acute thrombotic event. Thus, there is a need to identify new biomarkers that would correlate with the instability of plaque atheroma.
Few-shot Object Detection via Message Transfer Mechanism
Authors: Lv Wen , Shi Hongbo , Qi Xinwei , Song Bing , Tao Yang 
Published: July 2023

Abstract
Few-shot object detection aims to achieve object localization and recognition on novel classes with limited training instances. Due to the constraints of the two-stage fine-tuning mechanism, existing models lack the ability of knowledge reasoning. When transferring the base model to novel class detection, we add a RoI feature transfer branch, which establishes a message transfer mechanism between complex instances, ensuring mutual attraction between instances of the same category while allowing for association across different categories. Specifically, a self-attention message transfer graph is constructed to facilitate the propagation of attribute information among target instances. Secondly, a box transfer loss function is proposed combined semantic relationship among instances to promote mutual exclusion among instances with significant category attribute bias, thereby constructing better category feature representations. Finally, we demonstrate the effectiveness of our proposed framework compared to other state-of-the-art methods on two popular datasets, PASCAL VOC and MS-COCO.
YAP1 controls the N-cadherin-mediated tumor-stroma interaction in melanoma progression
Authors: Xio Yao , Zhou Lilni , Andl Thomas , Zhang Yuhang 
Published: July 2023

Abstract
Epithelial-to-mesenchymal transition (EMT) is crucial for melanoma cells to escape keratinocyte control, invade underlying dermal tissues, and metastasize to distant organs. The hallmark of EMT is the switch from epithelial cadherin (E-cadherin) to neural cadherin (N-cadherin), allowing melanoma cells to form a homotypic N-cadherin-mediated adhesion with stromal fibroblasts. However, how “cadherin switching” is initiated, maintained, and regulated in melanoma remains unknown. Here, we show that upon Yes-associated protein 1 (YAP1) ablation in cancer-associated fibroblasts (CAFs), the progression of a BRAF-mutant mouse melanoma was significantly suppressed in vivo, and overexpressing YAP1 in CAFs accelerated melanoma growth. CAFs require the YAP1 function to proliferate, migrate, remodel the cytoskeletal machinery and matrix, and promote cancer cell invasion. By RNA-Seq, N-cadherin was identified as a major downstream effector of YAP1 signaling in CAFs. YAP1 silencing led to N-cadherin downregulation in CAFs, which subsequently induced the downregulation of N-cadherin in neighboring melanoma cells. N-cadherin downregulation inhibited the PI3K-AKT signaling pathway in melanoma cells and suppressed melanoma growth in vivo, supporting the role of N-cadherin as an adhesive and signaling molecule in melanoma cells. This finding suggests that YAP1 depletion in CAFs induces the downregulation of p-AKT signaling in melanoma cells through the N-cadherin-mediated interaction between melanoma cells and CAFs. Importantly, our data underscore that CAFs can regulate N-cadherin-mediated interactions with melanoma cells. Thus, disentangling cadherin-mediated cell‒cell interactions can potentially disrupt tumor-stroma interactions and reverse the tumor cell invasive phenotype.
Influence of the low plasticity burnishing on surface quality and ultra-microhardness
Authors: de Oliveira Diogo Azevedo , Martins Augusto Moura , Santos Anderson Júnior dos , Magalhães Frederico de Castro , Abrão Alexandre Mendes 
Published: July 2023

Abstract
Low plasticity burnishing (LPB) is a mechanical operation that aims to improve surface quality and mechanical properties of components, as an increase on hardness and fatigue resistance. In this work, a LPB device was developed to be use on flat and complex surfaces. To evaluate is applicability on a machining center, LPB was conducted on flat surfaces of AISI 304 Stainless steel. Roughness, waviness, and microhardness were evaluated as a function of the number of passes (n) and burnishing speed (V). The burnishing tests results indicated that the device presented repeatability and stability. The number of burnishing passes influenced the microgeometric profile as well as the macrogeometric one. Considering the arithmetic mean roughness (Ra) an increase on both input parameters promoted a decrease of amplitude. Number of passes was the most significant parameter, reducing the profile amplitude by deforming the roughness peaks originated from previous passes. The increase on V also promoted a decrease on Ra. For maximum profile peak height (Rp) and maximum profile valley depth (Rv), the number of passes was the most significant parameter. The interaction between n and V was also significant. The waviness parameters also had distinct influences, for arithmetic mean waviness (Wa) only the Vn interaction was significant, for the maximum profile peak height (Wp) the main effects were significant and for maximum profile valley depth (Wv) only the interaction. The number of passes showed a more significant influence on microhardness and an increase of n resulted in higher values.
An Efficient CNN-based LSTM Approach to Detect the Rumor Prediction in COVID-19 Data using Fuzzy based Deep learning
Authors: Mukiri Raja Kumari , Burra Vijaya Babu 
Published: July 2023

Abstract
As the traditional rumor detection method is concerned, reduce in the data accuracy may influence the observation directivity and lack in the extraction of feature datasets. In order to overcome the above problem, here the modified rumor prediction model is proposed using deep learning with the integration of CNN in order to improve the data accuracy with the help of neural networks. First, the continuous bag of words (CBOW) model is modified to define the window context based on the definition of the weighted module. Then, CNN gets modified with the association of the attention module added along with the output of the weighted module as it helps to identify the feature incompleteness in the long sequence of online social networks. The attention module along with CNN with the function of max pooling and upsampling layer in order to extract the features in the text effectively. Then, the extracted feature is given into the softmax layer for performing text classification to identify and predict the rumor in the online social network. Based on the online samples, the analysis is conducted on the proposed model based on certain parameter such as, data accuracy, precision, recall and F1-Score as it shows better performance as compared to the other existing models like LSTM based Fuzzy deep learning, deep recurrent Q-learning and adaptive deep transfer learning.
MicroRNA-Mediated Obstruction of Stem-loop Alternative Splicing (MIMOSAS): a global mechanism for the regulation of alternative splicing
Authors: Zhai Rong , Ruan Kai , Perez German Farinas , Kubat Miroslav , Liu Jiaqi , Hofacker Ivo , Wuchty Stefan 
Published: July 2023

Abstract
While RNA secondary structures are critical to regulate alternative splicing of long-range pre-mRNA, the factors that modulate RNA structure and interfere with the recognition of the splice sites are largely unknown. Previously, we identified a small, non-coding microRNA that sufficiently affects stable stem structure formation of Nmnat pre-mRNA to regulate the outcomes of alternative splicing. However, the fundamental question remains whether such microRNA-mediated interference with RNA secondary structures is a global molecular mechanism for regulating mRNA splicing. We designed and refined a bioinformatic pipeline to predict candidate microRNAs that potentially interfere with pre-mRNA stem-loop structures, and experimentally verified splicing predictions of three different long-range pre-mRNAs in the Drosophila model system. Specifically, we observed that microRNAs can either disrupt or stabilize stem-loop structures to influence splicing outcomes. Our study suggests that MicroRNA-Mediated Obstruction of Stem-loop Alternative Splicing (MIMOSAS) is a novel regulatory mechanism for the transcriptome-wide regulation of alternative splicing, increases the repertoire of microRNA function and further indicates cellular complexity of post-transcriptional regulation.
Dual engagement of the nucleosomal acidic patches is essential for deposition of histone H2A.Z by SWR1C
Authors: Peterson Craig , Baier Alexander , Gioacchini Nathan , Eek Priit , Tan Song 
Published: July 2023

Abstract
The SWR1C chromatin remodeling enzyme catalyzes the ATP-dependent exchange of nucleosomal histone H2A for the histone variant H2A.Z, a key variant involved in a multitude of nuclear functions. How the 14-subunit SWR1C engages the nucleosomal substrate remains largely unknown. Numerous studies on the ISWI, CHD1, and SWI/SNF families of chromatin remodeling enzymes have demonstrated key roles for the nucleosomal acidic patch for remodeling activity, however a role for this nucleosomal epitope in nucleosome editing by SWR1C has not been tested. Here, we employ a variety of biochemical assays to demonstrate an essential role for the acidic patch in the H2A.Z exchange reaction. Utilizing asymmetrically assembled nucleosomes, we demonstrate that the acidic patches on each face of the nucleosome are required for SWR1C-mediated dimer exchange, suggesting SWR1C engages the nucleosome in a “pincer-like” conformation, engaging both patches simultaneously. Loss of a single acidic patch results in loss of high affinity nucleosome binding and nucleosomal stimulation of ATPase activity. We identify a conserved arginine-rich motif within the Swc5 subunit that binds the acidic patch and is key for dimer exchange activity. In addition, our cryoEM structure of a Swc5-nucleosome complex suggests that promoter proximal, histone H2B ubiquitinylation may regulate H2A.Z deposition. Together these findings provide new insights into how SWR1C engages its nucleosomal substrate to promote efficient H2A.Z deposition.
CERN-based Experiments and Monte Carlo Simulations on Focused VHEE (Very High Energy Electron) Beams For Radiotherapy
Authors: Whitmore Lucy , Mackay Ranald , Herk Marcel van , Korysko Pierre , Farabolini Wilfrid , Malyzhenkov Alexander , Corsini Roberto , Jones Roger Michael 
Published: July 2023

Abstract
Very High Energy Electrons (VHEEs) are a promising alternative to conventional radiotherapy due to their highly penetratingnature and their applicability as a modality for FLASH (ultra-high dose rate) radiotherapy. The dose distributions due to VHEE need to be optimised; one option is through the use of quadrupole magnets to focus the beam, reducing the dose to healthy tissue and allowing for targeted dose delivery at conventional or FLASH dose rates. This paper presents the first targeted area of focused VHEE dose delivery in air and a water phantom, obtained using six quadrupoles at fixed field strengths and adjusted by changing only the strength of one quadrupole and the beam charge at the CLEAR (CERN Linear Electron Accelerator forResearch) facility for beam energies >200 MeV. Experimental results have been verified with Monte Carlo modelling. This targeted dose delivery method in the form of a ’Spread-Out Electron Peak’ (SOEP), analogous to the Spread-Out Bragg Peak(SOBP) for protons, could potentially be used in future (FLASH) VHEE treatments. As a step towards this, the effect of the vacuum beampipe aperture size and spacings between quadrupoles were explored and optimised in Monte Carlo simulations.
Study on the correlation between intestinal flora and trimethylamine oxide on gallbladder stone formation
Authors: Zhang Yang , Wang Qi , Wang Xiaowen , Yang Jiming 
Published: July 2023

Abstract
In patients with gallbladder stones, there are differences in intestinal flora, oxidized trimethylamine, triglyceride and cholesterol levels compared to the healthy population. We investigated whether there is a correlation between gallbladder stones and intestinal flora and other outcomes to provide a new reference for gallbladder stone prevention and treatment. We used 40 patients with gallbladder stones who met the inclusion criteria in the Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, from January 2021 to December 2021 as a case group. During the same period, 35 medical examiners who underwent health checkups at our hospital served as the control group. We extracted blood, urine, and stool specimens from the case and control groups for the study and analysis of relevant indexes. We found no significant difference in the levels of the phylum Thick-walled Bacteroides and Bacteroides in the case and control populations at the level of bacterial phylum. In the case group population the content of Aspergillus was higher than in the control group (P<0.05). At the level of bacterial genera, the levels of Enterococcus faecalis, Eubacterium were increased in the case group compared to the control group (P<0.05). The levels of trimethylamine oxide in blood and urine were higher in the case group population than in the control group (P<0.05). In contrast, the triglyceride and cholesterol levels in both groups, were not statistically significant (P>0.05). Therefore, we conclude that the distribution of intestinal flora and the abnormalities of oxidized trimethylamine in patients with gallbladder stones suggest that there may be a correlation between these two types of factors on gallbladder stone formation.
Regional and seasonal differences of radar reflectivity slopes in lower troposphere in convective and stratiform precipitation using TRMM PR data
Authors: Kumar Shailendra 
Published: July 2023

Abstract
Slopes of radar reflectivity below freezing height (FZH) is a critical parameter to estimate the correct rainfall near the surface. TRMM PR based radar reflectivity slopes is presented here, during Indian and Austral summer monsoon by calculating them in lower troposphere (< 4 km). Slopes are either positive or negative, which means they are either decreasing or increasing towards the surface. In majority of cases, slopes decrease towards the surface over land, but increases towards the surface over ocean. A close similarity has been observed in the tropical oceanic areas in convective precipitation and Arabian Ocean consists of the highest fraction (89.10~%) of negative slopes, whereas Bay of Bengal has the highest fraction of positive slopes (21~%) in convective precipitation. Western Himalaya Foothills has the highest fraction of positive slope in convective precipitation and shows that ~ 76% and 83% of convective and stratiform profiles decrease towards the surface. During Austral summer monsoon Maritime Continent consists of the highest fraction of negative slopes (~ 92%%) in convective precipitation followed by Equatorial Indian Ocean. Land vs ocean and regional differences in radar reflectivity slopes are higher in convective precipitation compared to stratiform precipitation. Vertical profiles with extreme positive (> 1) slopes have higher ETH in convective precipitation over tropical ocean during both the seasons, whereas over the land higher ETHs are contributing to negative slopes.