bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new model predicts hepatocellular carcinoma in patients with HBV-related decompensated liver cirrhosis and long-term antiviral therapy: a prospective study
Authors: Mao Hao-dan , Zheng Shu-qin , Yang Su-hua , Huang Ze-yu , Xue Yuan , Zhou Min 
Published: March 2023

Background
We aimed to evaluate the prediction values of non-invasive models for hepatocellular carcinoma (HCC) development in patients with HBV-related liver cirrhosis (LC) and long-term NA treatment.

Methods
Patients with compensated or decompensated cirrhosis (DC), who achieved long-term virological response, were enrolled. DC and its stages were defined by the complications including ascites, encephalopathy, variceal bleeding, or renal failure. Prediction accuracy of several risk scores, including ALBI, CAMD, PAGE-B, mPAGE-B and aMAP, was compared.

Results
The median follow-up duration was 37 (28–66) months. Among the 229 patients, 9 (9.57%) patients in the compensated LC group and 39 (28.89%) patients in the DC group developed HCC. The incidence of HCC was higher in the DC group ($\cal X$2 = 12.478, P < 0.01). The AUROC of ALBI, aMAP, CAMD, PAGE-B and mPAGE-B scores were 0.512, 0.667, 0.638, 0.663, 0.679, respectively. There was no significant difference in AUROC between CAMD, aMAP, PAGE-B and mPAGE-B (all P > 0.05). Univariable analysis showed that age, DC status and platelet were associated with HCC development, and multivariable analysis showed that age and DC status (both P < 0.01) were independent risk factors for HCC development, then Model (Age_DC) was developed and its AUROC was 0.718. Another model, Model (Age_DC_PLT_TBil) consisting of age, DC stage, PLT, TBil was also developed, and its AUROC was larger than that of Model (Age_DC) (0.760 vs. 0.718). Moreover, AUROC of Model (Age_DC_PLT_TBil) was larger than the other five models (all P < 0.05). With an optimal cut-off value of 0.236, Model (Age_DC_PLT_TBil) achieved 70.83% sensitivity, 76.24% specificity.

Conclusion
There is a lack of non-invasive risk scores for HCC development in HBV-related DC, and a new model consisting of age, DC stage, PLT, TBil may be an alternative.
Assessment of Farmers’ Resilience to Climate – Related Disasters in Oyo State, Nigeria
Authors: S. Amusat, A. , K. Amusat, K. , T. Omisope, E. 
Published: March 2023

The study assessed farmers’ resilience to climate related disasters in Oyo State, Nigeria. Simple random sampling technique was used to select 153 farmers from the list of those who have previously experienced climate related disaster in the state. Results indicate that 58.8% of the respondents were male, 37.3% did not have formal education, 80.4% were married and 59.4% used family labour. Majority (85.0%) were not aware of agricultural insurance scheme while 49.0% were aware of emergency response scheme of the government. The most available resilience options to farmers were improve variety of seeds (88.2%) and agro technologies (88.2%) while the most frequently experienced climate related disaster were drought (=1.20) and flood (=1.18). Also, drought (=1.38) and flood ( =1.37) were the most severe among the climate related disaster experienced in the study area while respondents had high capacity to mitigate pest infestation (=2.72) and forest fire (= 1.80). Low level of knowledge ( =1.50) and poor response from emergency management of governments (=1.46) were the major constraints to mitigation of climate related disaster in the study area. Significant relationship existed between respondents’ education (χ2=16.34;P=0.001) and their resilience to climate related disaster. Efforts should be made to provide capacity building for farmers on possible ways of mitigating negative effects of climate change in the study area.
Association Between Hospital Adoption of an Emergency Department Treatment Pathway for Opioid Use Disorder and Patient Initiation of Buprenorphine After Discharge
Authors: Solomon Keisha T. , O’Connor Jason , Gibbons Jason B. , Kilaru Austin S. , Feder Kenneth A. , Xue Lingshu , Saloner Brendan , Stuart Elizabeth A. , Cole Evan S. , Hulsey Eric , Meisel Zachary , Patel Esita , Donohue Julie M. 
Published: March 2023

ImportanceEmergency department (ED)–based initiation of buprenorphine has been shown to increase engagement in outpatient treatment and reduce the risk of subsequent opioid overdose; however, rates of buprenorphine treatment in the ED and follow-up care for opioid use disorder (OUD) remain low in the US. The Opioid Hospital Quality Improvement Program (O-HQIP), a statewide financial incentive program designed to increase engagement in OUD treatment for Medicaid-enrolled patients who have ED encounters, has the potential to increase ED-initiated buprenorphine treatment.ObjectiveTo evaluate the association between hospitals attesting to an ED buprenorphine treatment O-HQIP pathway and patients’ subsequent initiation of buprenorphine treatment.Design, Setting, and ParticipantsThis cohort study included Pennsylvania patients aged 18 to 64 years with continuous Medicaid enrollment 6 months before their OUD ED encounter and at least 30 days after discharge between January 1, 2016, and December 31, 2020. Patients with a claim for medication for OUD 6 months before their index encounter were excluded.ExposuresHospital implementation of an ED buprenorphine treatment O-HQIP pathway.Main Outcomes and MeasuresThe main outcome was patients’ receipt of buprenorphine within 30 days of their index OUD ED visit. Between August 2021 and January 2023, data were analyzed using a difference-in-differences method to evaluate the association between hospitals’ O-HQIP attestation status and patients’ treatment with buprenorphine after ED discharge.ResultsThe analysis included 17 428 Medicaid-enrolled patients (female, 43.4%; male, 56.6%; mean [SD] age, 37.4 [10.8] years; Black, 17.5%; Hispanic, 7.9%; White, 71.6%; other race or ethnicity, 3.0%) with OUD seen at O-HQIP–attesting or non–O-HQIP–attesting hospital EDs. The rate of prescription fills for buprenorphine within 30 days of an OUD ED discharge in the O-HQIP attestation hospitals before the O-HQIP intervention was 5%. The O-HQIP attestation was associated with a statistically significant increase (2.6 percentage points) in prescription fills for buprenorphine within 30 days of an OUD ED discharge (β, 0.026; 95% CI, 0.005-0.047).Conclusions and RelevanceIn this cohort study, the O-HQIP was associated with an increased initiation of buprenorphine in patients with OUD presenting to the ED. These findings suggest that statewide incentive programs may effectively improve outcomes for patients with OUD.
A Boronate Ester Driven Rechargeable Antibacterial Membrane for Fast Molecular Sieving
Authors: Yi Ming , Nguyen Thi Dao , Liu Huan , Liu Yafang , Xiong Shu , Wang Yan 
Published: March 2023

AbstractMembrane decorated with biocides is an effective way to suppress biofilm growth. However, their immediate biocidal effect usually suffers from a significant decline due to the irreversible consumption of the biocides. Here, a smart nanofiltration membrane is reported with rechargeable antibacterial capability that is fabricated by a facile interfacial polymerization via 3‐aminophenylboronic acid and trimesoyl chloride on a polysulfone substrate. Biocides bearing diol groups can be grafted onto the membrane surface under neutral/alkaline condition and then released from the surface under acidic environment, due to the pH‐responsive feature of boronate ester complexes. The resultant membrane exhibits integrated properties of fast bacterial inactivating efficiency, rechargeable antibacterial capability, and impressive stability. In addition, the achieved membrane shows remarkable separation efficiency to dye/monovalent salt system. The successful fabrication of the membrane with rechargeable anti‐bacterial property provides new insights into the development of pH‐responsive and sustainable antibacterial membranes.
Comment on “Vapor Lubrication for Reducing Water and Ice Adhesion on Poly(dimethylsiloxane) Brushes”: Vapor Alteration Alone Reduces Water Droplet Adhesion
Authors: Khatir Behrooz , Golovin Kevin 
Published: March 2023

AbstractA reduction in lateral adhesion of water droplets on poly(dimethylsiloxane) (PDMS) brush surfaces exposed to various vapor conditions was recently reported. It was suggested that the mobility of droplets is due to swelling of the PDMS brushes. When changing the vapor surrounding sliding droplets on bare surfaces, a similar phenomenon is observed, presenting a much simpler explanation of the observed results.
Water‐Stable and Photo‐Patternable Siloxane‐Encapsulated Upconversion Nanoparticles toward Flexible Near‐Infrared Phototransistors
Authors: Lee Injun , Park Cheolmin , Kim Tae Soo , Kang Minsoo , Oh Hyeongyeol , Jang Jinhyeong , Park Jungjae , Yuk Jong Min , Lee Hohjai , Park Chan Beum , Choi Sung‐Yool , Kang Kibum , Lee Wonryung , Bae Byeong‐Soo 
Published: March 2023

AbstractUpconversion nanoparticles (UCNPs), as near‐infrared (NIR) absorbers, are promising materials for use in flexible NIR photodetectors, which can be applied for wearable healthcare applications due to their advantages in a broad spectral range, high photostability, and biocompatibility. However, to apply UCNPs in wearable and large‐area integrated devices, water stability and micro‐patterning methods are required. In this work, the UCNPs are encapsulated with a siloxane polymer (UCNP@SiOx) via a sol–gel process to enable photo‐patternability and photo‐stabililty in water conditions. The UCNP@SiOx can be photo‐patterned down to micron‐scale feature sizes and exhibit no significant decrease in upconversion photoluminescence (PL) intensities and PL decay time after immersion in water for 2 h. Moreover, UCNP@SiOx is evaluated by an in vitro biocompatibility test and found to be non‐toxic. By integrating the UCNP@SiOx with MoS2 phototransistors (MoS2 + UCNP@SiOx), the devices exhibit enhanced responsivity (0.79 A W−1) and specific detectivity (2.22 × 107 Jones), which are 2.8 times higher than in the bare MoS2 phototransistors, and excellent mechanical durability over 1000 cycles of 20% compression and re‐stretch test. This work opens the way for the facile synthesis of water‐stable and photo‐patternable siloxane‐encapsulated UCNPs and a strategy for fabricating high‐performance flexible NIR phototransistors through wavelength conversion.
Energy‐Level Regulation and Low‐Dimensional Phase Rearrangement via a Multifunctional Spacer Group toward Efficient Sky‐Blue Quasi‐2D Perovskite Light‐Emitting Diodes
Authors: Zhu Chunrong , Zhao Chenjing , Yuan Fang , Li Yuren , Li Jingrui , Liu Xiaoyun , Li Lu , Dong Hua , Yan Lihe , Wang Shuangpeng , Jiao Bo , Wu Zhaoxin 
Published: March 2023

AbstractQuasi‐2D perovskite materials have great potential for achieving high‐performance blue perovskite light‐emitting diodes (PeLEDs). Major challenges lie in the need to minimize the energy level mismatch between the blue‐emitting and the charge‐transport materials for better carrier injection, and to suppress low‐dimensional phases in quasi‐2D systems for improved radiation recombination. Here, this work introduces a subtly functionalized compound, methoxylated phenethylammonium bromide (y‐MeO‐PEABr), into the sky‐blue quasi‐2D perovskite. This approach induces an upward shift of the energy levels of the perovskite and reduces the holes injection barrier, thereby achieving a better charge balance. In addition, the introduction of large y‐MeO‐PEA+ cations effectively suppresses the formation of undesirable phases in quasi‐2D perovskites, leading to a more concentrated phase distribution and accelerated energy transfer. Specifically, the sky‐blue quasi‐2D PeLED based on 2‐MeO‐PEABr exhibits optimal device performance, obtaining a maximum external quantum efficiency of 10.85% at 486 nm. This work suggests that this method may provide a guide for designing novel organic spacer cations to obtain high‐performance blue quasi‐2D PeLEDs.
A Mechanochemically Synthesized Hybrid Bismuth Halide as Highly Efficient Red Phosphor for Blue Chip‐Based WLED
Authors: Zhuang Tinghui , Lin Yanpeng , Jin Jiance , Deng Zhonghua , Peng Yingchen , Gong Liaokuo , Wang Zeping , Du Kezhao , Huang Xiaoying 
Published: March 2023

AbstractIn recent decades, white light‐emitting diodes (WLEDs) assembled by blue light‐emitting diodes (LEDs) and down‐conversion phosphors have gained rapid development. Thereinto, red phosphors, especially for the ecofriendly and cost‐effective ones, serve an important role for the preparation of superior WLEDs. Herein, a halide compound with a 0D crystal structure, namely [PPh4]2[Bi2Br8(bp4do)(DMSO)2] (BiBrON, PPh4 = tetraphenylphosphonium, bp4do = 4,4′‐bipyridine 1,1′‐dioxide, DMSO = dimethyl sulfoxide) is synthesized at gram scale via a mechanochemical synthesis method. Photophysical properties of BiBrON are investigated in detail. BiBrON has the highest efficiency (78.20%) of red phosphorescence among the Bi‐based halides. The red emission of BiBrON is blue‐light‐excitable with 99.9% color purity and outstanding thermal stability below 400 K. The optical absorption‐emission mechanism in BiBrON is elucidated by the combination study of experiments and density functional theory calculations. BiBrON can be applied as a red phosphor in the blue LED chip‐based WLED with high color rendering index of 87.8, that is higher than the one fabricated utilizing commercial red phosphor (610 nm), and ideal Commission International de l'Eclairage chromaticity coordinate of (0.3282, 0.3311). This work demonstrates for the first time the great potential of Bi‐inorganic–organic hybrid material as phosphors applied for WLED.
Thermally Activated Delayed Fluorescence from Perovskite‐Derivative CsAgCl2 Nanocrystals for High‐Resolution X‐Ray Imaging
Authors: Lin Qun , Wang Zhaoyu , Wei Youchao , Chen Yameng , Li Xiaohan , Liu Yongsheng , Hong Maochun 
Published: March 2023

AbstractThermally activated delayed fluorescence (TADF) materials hold great promise as next‐generation efficient emitters due to their theoretical 100% internal quantum efficiency. However, such an intriguing photophysical mechanism is extremely rare in perovskites or their derivatives. Herein, the colloidal synthesis of two‐dimensional CsAgCl2 nanocrystals (NCs) with typical TADF feature is reported first. The TADF mechanism is investigated in detail by combining first‐principles calculations with experimental results, including temperature‐dependent spectral analysis and fs‐transient absorption spectra. A small singlet−triplet state splitting energy (0.082 eV) and a large spatial separation of charge density |Ψ|2 of valence band maximum and conduction band minimum are observed, which are prerequisites for TADF. Moreover, these CsAgCl2 NCs deliver an ultralow X‐ray detection limit of 170.5 nGyair s−1 and a high imaging resolution of 11.5 lp mm−1, much superior to the commercial scintillators.
Experimental Observation of Vector Bound States in the Continuum
Authors: Zhang Huizhen , Zhang Weixuan , Chen Shaohu , Duan Pengfei , Li Junjie , Shi Lei , Zi Jian , Zhang Xiangdong 
Published: March 2023

AbstractBound states in the continuum (BICs) provide an important way for creating photonic devices reliant upon optical modes with high Q‐factors. However, current experimental implementations of BICs in photonic crystal (PhC) slabs only possess a certain polarization, which fundamentally restricts their use to surface‐enhanced applications assisted by scalar‐polarized near fields. In this work, vector BICs in PhC slabs are theoretically designed and experimentally realized. In theory, the symmetry‐protected vector BICs can be constructed by tuning geometric parameters of the PhC slab, where the coalescence of eigenfrequencies for a pair of TE‐ and TM‐like modes appears. It is found that the homogeneous superchiral fields with three orders of magnitude larger than circular polarized lights can be achieved, assisted by vector quasi‐BICs. Furthermore, Si3N4PhC slabs are experimentally fabricated and their band structures are measured. It is shown that a pair of symmetry‐protected BICs with TE‐ and TM‐like polarizations can coalesce with each other at a suitable value for the diameter of array holes, indicating the realization of vector BICs. This work can possess important applications in the field of ultrasensitive detections of molecular chirality.
Cobalt‐Catalyzed Allylic Defluorinative Cross‐Electrophile Coupling between 1,1‐Difluoroalkyl Halides and α‐Trifluoromethyl Styrenes
Authors: Dong Haiyan , Lin Zhiyang , Wang Chuan 
Published: March 2023

AbstractIn this protocol, we apply reductive cobalt catalysis in the allylic defluorinative cross‐electrophile coupling reaction between 1,1‐difluoroalkyl halides and α‐trifluoromethyl styrenes. This reaction features broad substrate scope (39 examples), good tolerance of various functionalities, and circumvention of pregenerating organometallics, offering a general synthetic route to prepare diverse organofluorines incorporating both agem‐difluoroalkene and agem‐difluoroalkane moiety.magnified image
Orai1 is an Entotic Ca2+ Channel for Non‐Apoptotic Cell Death, Entosis in Cancer Development
Authors: Lee Ah Reum , Park Chan Young 
Published: March 2023

AbstractEntosis is a non‐apoptotic cell death process that forms characteristic cell‐in‐cell structures in cancers, killing invading cells. Intracellular Ca2+ dynamics are essential for cellular processes, including actomyosin contractility, migration, and autophagy. However, the significance of Ca2+ and Ca2+ channels participating in entosis is unclear. Here, it is shown that intracellular Ca2+ signaling regulates entosis via SEPTIN‐Orai1‐Ca2+/CaM‐MLCK‐actomyosin axis. Intracellular Ca2+ oscillations in entotic cells show spatiotemporal variations during engulfment, mediated by Orai1 Ca2+ channels in plasma membranes. SEPTIN controlled polarized distribution of Orai1 for local MLCK activation, resulting in MLC phosphorylation and actomyosin contraction, leads to internalization of invasive cells. Ca2+ chelators and SEPTIN, Orai1, and MLCK inhibitors suppress entosis. This study identifies potential targets for treating entosis‐associated tumors, showing that Orai1 is an entotic Ca2+ channel that provides essential Ca2+ signaling and sheds light on the molecular mechanism underlying entosis that involves SEPTIN filaments, Orai1, and MLCK.
Organocatalytic Enantioselective Synthesis of 1,3‐Oxazinanes and Hexahydropyrimidines via [4+2]‐Annulation of CyclicN‐Sulfimines
Authors: Yeon Kim Seung , Kim Yoseop , Kim Sung‐Gon 
Published: March 2023

AbstractThe first asymmetric synthetic method for enantioenriched 1,3‐oxazinane and hexahydropyrimidine derivatives via the asymmetric [4+2]‐annulation of cyclicN‐sulfimines has been established. The reaction of cyclicN‐sulfimines with δ‐hydroxy‐α,β‐unsaturated ketones afforded a wide range of enantioenriched polyheterotricyclic 1,3‐oxazinane derivatives in high yields with good to excellent enantioselectivities in the presence of a cinchonidine‐derived squaramide catalyst. This approach has been extended to the asymmetric organocatalytic [4+2]‐annulation of cyclicN‐sulfimines with δ‐NHTs‐α,β‐unsaturated ketones providing enantioenriched hexahydropyrimidines. In addition, the asymmetric [4+2]‐annulation of δ‐hydroxy‐ and δ‐NHTs‐α,β‐unsaturated ketones gave their corresponding enantioenriched 1,3‐oxazinane and hexahydropyrimidine derivatives with different absolute configurations.
Sexually dimorphic age‐related molecular differences in the entorhinal cortex of cognitively intact elderly: Relation to early Alzheimer's changes
Authors: Chen Xin‐Lu , Fortes Jennifer Monteiro , Hu Yu‐Ting , van Iersel Juliet , He Kang‐Ning , van Heerikhuize Joop , Balesar Rawien , Swaab Dick , Bao Ai‐Min 
Published: March 2023

AbstractIntroductionWomen are more vulnerable to Alzheimer's disease (AD) than men. The entorhinal cortex (EC) is one of the earliest structures affected in AD. We identified in cognitively intact elderly different molecular changes in the EC in relation to age.MethodsChanges in 12 characteristic molecules in relation to age were determined by quantitative immunohistochemistry or in situ hybridization in the EC. They were arbitrarily grouped into sex steroid‐related molecules, markers of neuronal activity, neurotransmitter‐related molecules, and cholinergic activity‐related molecules.ResultsThe changes in molecules indicated increasing local estrogenic and neuronal activity accompanied by a higher and faster hyperphosphorylated tau accumulation in women's EC in relation to age, versus a mainly stable local estrogenic/androgenic and neuronal activity in men's EC.DiscussionEC employs a different neurobiological strategy in women and men to maintain cognitive function, which seems to be accompanied by an earlier start of AD in women.HIGHLIGHTS
Local estrogen system is activated with age only in women's entorhinal cortex (EC).
EC neuronal activity increased with age only in elderly women with intact cognition.
Men and women have different molecular strategies to retain cognition with aging.
P‐tau accumulation in the EC was higher and faster in cognitively intact elderly women.
Efficient removal of Cr(VI) from aqueous solutions using chitosan/Na‐alginate bio‐based nanocomposite hydrogel
Authors: Mahmoud Ghada A. , Sayed Asmaa , Abdel‐raouf Manar El‐Sayed , Danial Mina Y. F. , Amin Ayman 
Published: March 2023

AbstractThis research article aimed to assist the works conducted to save water resources, which are rapidly depleted as a result of climate change by eliminating toxic chromium ions Cr(VI) from simulated solution. In this regard, chitosan/Na‐alginate/polyacrylic acid (CS/Na‐Alg/PAAc) and Ni/chitosan/Na‐alginate/polyacrylic acid (Ni@CS/Na‐Alg/PAAc) were created as eco‐friendly hydrogel composites via gamma radiation. The hydrogel matrix served as a basin for the in‐situ formation of Ni nanoparticles. The prepared composites were characterized by the FTIR and XRD analyses. The surface morphology of the nanocomposite was also verified via the SEM. It exhibited a dense packing of the Ni nanoparticles representing about 2.5% of the atomic percentage depicted by the EDX analysis. The swelling performance was investigated versus different pH values and the maximum swelling percent was attained as a non‐Fickian character at pH = 13 and 5 for CS/Na‐Alg/PAAc and Ni@CS/Na‐Alg/PAAc, respectively. Furthermore, the surface topographies of CS/Na‐Alg/PAAc and Ni@CS/Na‐Alg/PAAc loaded with Cr(VI) were examined by AFM at different pH values. The maximum Cr(VI) removal was top achieved at pH 8 (58.06 and 74.5 mg/g for CS/Na‐Alg/PAAc and Ni@CS/Na‐Alg/PAAc, respectively) and best fit with the Freundlich isotherm model with calculated RL values indicated a favorable adsorption.