bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pilot survey of selenium status and its geospatial variation among children and women in three rural districts of Zimbabwe
Authors: Mutonhodza Beaula , Chagumaira Christopher , Dembedza Mavis P. , Joy Edward J. M. , Manzeke-Kangara Muneta G. , Njovo Handrea , Nyadzayo Tasiana K. , Lark R. Murray , Kalimbira Alexander A. , Bailey Elizabeth H. , Broadley Martin R. , Matsungo Tonderayi M. , Chopera Prosper 
Published: July 2023

IntroductionSelenium (Se) deficiency is increasingly recognized as a public health problem in sub-Saharan Africa.MethodsThe current cross-sectional study assessed the prevalence and geospatial patterns of Se deficiency among children aged 6–59 months (n = 741) and women of 15–49 years old (n = 831) selected by simple random sampling in rural Zimbabwe (Murewa, Shamva, and Mutasa districts). Venous blood samples were collected and stored according to World Health Organization guidelines. Plasma Se concentration was determined by inductively coupled plasma-mass spectrometry.ResultsMedian, Q1, and Q3 plasma Se concentrations were 61.2, 48.7, and 73.3 μg/L for women and 40.5, 31.3, and 49.5 μg/L for children, respectively. Low plasma Se concentrations (9.41 μg/L in children and 10.20 μg/L in women) indicative of severe Se deficiency risk was observed. Overall, 94.6% of children and 69.8% of women had sub-optimal Se status defined by plasma Se concentrations of &lt;64.8 μg/L and &lt;70 μg/L, respectively.DiscussionHigh and widespread Se deficiency among women and children in the three districts is of public health concern and might be prevalent in other rural districts in Zimbabwe. Geostatistical analysis by conditional kriging showed a high risk of Se deficiency and that the Se status in women and children in Murewa, Shamva, and Mutasa districts was driven by short-range variations of up to ⁓12 km. Selenium status was homogenous within each district. However, there was substantial inter-district variation, indicative of marked spatial patterns if the sampling area is scaled up. A nationwide survey that explores the extent and spatial distribution of Se deficiency is warranted.
Hypoglycemic agents and incidence of pancreatic cancer in diabetic patients: a meta-analysis
Authors: Zhao Zimo , He Xinyi , Sun Yan 
Published: July 2023

Background and aims: Hypoglycemic agents are the primary therapeutic approach for the treatment of diabetes and have been postulated to impact pancreatic cancer (PC) incidence in diabetic patients. We conducted a meta-analysis to further evaluate and establish the associations between four common types of hypoglycemic agents [metformin, sulfonylureas, thiazolidinediones (TZDs), and insulin] and PC incidence in individuals with diabetes mellitus (DM).Methods: A comprehensive literature search of PubMed, Web of Science, Embase, and the Cochrane Library identified studies that analyzed the relationship between hypoglycemic agents and PC published between January 2012 and September 2022. Randomized control trials (RCTs), cohorts, and case–control studies were included if there was clear and evaluated defined exposure to the involved hypoglycemic agents and reported PC outcomes in patients with DM. Furthermore, reported relative risks or odds ratios (ORs) or other provided data were required for the calculation of odds ratios. Summary odds ratio estimates with a 95% confidence interval (CI) were estimated using the random-effects model. Additionally, subgroup analysis was performed to figure out the source of heterogeneity. Sensitivity analysis and publication bias detection were also performed.Results: A total of 11 studies were identified that evaluated one or more of the hypoglycemic agents, including three case–control studies and eight cohort studies. Among these, nine focused on metformin, six on sulfonylureas, seven on TZDs, and seven on insulin. Meta-analysis of the 11 observational studies reported no significant association between metformin (OR = 1.04, 95% CI 0.73–1.46) or TZDs (OR = 1.13, 95% CI 0.73–1.75) and PC incidence, while the risk of PC increased by 79% and 185% with sulfonylureas (OR = 1.79, 95% CI 1.29–2.49) and insulin (OR = 2.85, 95% CI 1.75–4.64), respectively. Considerable heterogeneity was observed among the studies and could not be fully accounted for by study design, region, or adjustment for other hypoglycemic agents.Conclusion: Sulfonylureas and insulin may increase the incidence of pancreatic cancer in diabetic patients, with varying effects observed among different ethnicities (Asian and Western). Due to significant heterogeneity across studies, further interpretation of the relationship between hypoglycemic agents and pancreatic cancer incidence in diabetic patients requires well-adjusted data and better-organized clinical trials.
Liraglutide ameliorates diabetic-induced testicular dysfunction in male rats: role of GLP-1/Kiss1/GnRH and TGF-β/Smad signaling pathways
Authors: Fathy Maha Abdelhamid , Alsemeh Amira Ebrahim , Habib Marwa A. , Abdel-nour Hanim M. , Hendawy Doaa M. , Eltaweel Asmaa Monir , Abdelkhalek Adel , Ahmed Mona M. , Desouky Maha K. , Hua Jinlian , Fericean Liana Mihaela , Banatean-Dunea Ioan , Arisha Ahmed Hamed , Khamis Tarek 
Published: July 2023

Introduction: Glucagon-like peptide -1 (GLP-1) is released by intestinal cells to stimulate glucose-dependent insulin release from the pancreas. GLP-1 has been linked to ameliorating obesity and/or diabetic complications as well as controlling reproductive function. Liraglutide is a GLP-1 receptor agonist (GLP-1RA) with 97% homology with GLP-1. The main objective of this study was to investigate the ameliorative role of liraglutide in diabetic-induced reproductive dysfunction in male rats.Methods: Rats were randomly allocated into 3 groups; a control group, a diabetic group, and a liraglutide-treated diabetic group.Results: In the diabetic group, a significant increase in BMI, FBG, HbA1c, HOMA-IR, TC, TAG, LDL, IL6, TNFα, and MDA, as well as decreased serum insulin, HDL, GSH, total testosterone, LH, and FSH, were shown compared to the control group. Furthermore, A significant downregulation in relative hypothalamic gene expression of GLP-1R, PPAR-α, PGC-1α, kiss, kiss1R, leptin, leptin R, GnRH GLP-1R, testicular PGC-1α, PPARα, kiss1, kiss1R, STAR, CYP17A1, HSD17B3, CYP19A, CYP11A1, and Smad7, as well as upregulation in hypothalamic GnIH and testicular TGF- β and Smad2 expression, were noticed compared to the control group. Liraglutide treatment significantly improved such functional and structural reproductive disturbance in diabetic rats.Conclusion: GLP-1RAs ameliorated the deleterious effects of diabetes on reproductive function by targeting GLP-1/leptin/kiss1/GnRH, steroidogenesis, and TGF- β/Smad pathways.
Integration analysis of senescence-related genes to predict prognosis and immunotherapy response in soft-tissue sarcoma: evidence based on machine learning and experiments
Authors: Qi Lin , Chen Fangyue , Wang Lu , Yang Zhimin , Zhang Wenchao , Li Zhihong 
Published: July 2023

Background: Soft tissue sarcoma (STS) is the malignancy that exhibits remarkable histologic diversity. The diagnosis and treatment of STS is currently challenging, resulting in a high lethality. Chronic inflammation has also been identified as a key characteristic of tumors, including sarcomas. Although senescence plays an important role in the progression of various tumors, its molecular profile remains unclear in STS.Methods: We identified the senescence-related genes (SRGs) in database and depicted characteristics of genomic and transcriptomic profiling using cohort within TCGA and GEO database. In order to investigate the expression of SRGs in different cellular subtypes, single-cell RNA sequencing data was applied. The qPCR and our own sequencing data were utilized for further validation. We used unsupervised consensus clustering analysis to establish senescence-related clusters and subtypes. A senescence scoring system was established by using principal component analysis (PCA). The evaluation of clinical and molecular characteristics was conducted among distinct groups.Results: These SRGs showed differences in SCNV, mutation and mRNA expression in STS tissues compared to normal tissues. Across several cancer types, certain shared features of SRGs were identified. Several SRGs closely correlated with immune cell infiltration. Four clusters related to senescence and three subtypes related to senescence, each with unique clinical and biological traits, were established. The senescence scoring system exhibited effectiveness in predicting outcomes, clinical traits, infiltrations of immune cells and immunotherapy responses.Conclusion: Overall, the current study provided a comprehensive review of molecular profiling for SRGs in STS. The SRGs based clustering and scoring model could help guiding the clinical management of STS.
Effects of different exercise modalities and intensities on body composition in overweight and obese children and adolescents: a systematic review and network meta-analysis
Authors: Huang Zan , Li Jiayu , Liu Yanjie , Zhou Yulan 
Published: July 2023

Introduction: Childhood and adolescent overweight and obesity are global public health issues. Previous studies on exercise and overweight and obese children have produced inconsistent findings and lacked comparisons between different exercise modalities and intensities. Therefore, a network meta-analysis is necessary to provide evidence-based intervention programs. This study aims to identify the effects of different exercise modalities and intensities on changes in body composition in overweight and obese children and adolescents.Methods: A search for randomized controlled trials was conducted on Web of Science, PubMed, Scopus, and Embase involving exercise interventions aimed at improving body composition (body fat percentage, BMI, fat mass, fat-free mass, body weight) in overweight and obese children and adolescents. A random effects network meta-analysis was performed using STATA 14.0 software within a frequentist framework. The literature quality was assessed using the Cochrane Risk of Bias Tool 2.0.Results: Thirty-two papers involving 1,452 participants were included. There were six types of intervention involved in the study, including moderate intensity aerobic exercise, high-intensity aerobic exercise, moderate intensity resistance exercise, high-intensity resistance exercise, moderate intensity combined exercise, and high-intensity combined exercise. The network meta-analysis results revealed that high-intensity combined exercise was the best exercise mode for improving BMI [mean difference in kg/m2 = −1.65, 95% CI (−3.27, −0.02)] and reducing fat mass [mean difference in kg = −2.87, 95% CI (−4.84, −0.91)]. Moderate intensity combined exercise was the best mode for weight loss [mean difference in kg = −4.58, 95% CI (−5.94, −3.22)] and improvement in body fat percentage [mean difference in% = −2.52, 95% CI (−3.83, −1.20)]. High-intensity resistance exercise had the optimal effect in increasing fat-free mass [mean difference in kg = 1.10, 95% CI (0.22, 1.99)].Conclusion: In conclusion, the study found that combined exercise, whether moderate or high intensity, was more effective than any other exercise modality in improving body fat percentage and BMI, reducing fat mass and weight. Resistance exercise was the most effective in increasing fat-free mass.
The effect of parenting styles on Chinese undergraduate nursing students’ academic procrastination: the mediating role of causal attribution and self-efficacy
Authors: Li Yuanyuan , Dong Wanglin , Tang Haishan , Guo Xiajun , Wu Sijia , Lu Guangli , Chen Chaoran 
Published: July 2023

BackgroundAcademic procrastination is common among college students, but there is a lack of research on the influencing mechanism of academic procrastination among nursing students. The purpose of this study was to explore the influence of parental rearing patterns on academic procrastination of nursing students, and the mediating role of causal attribution and self-efficacy.MethodsUsing Parental Bonding Instrument, Aitken Procrastination Inventory, Multidimensional Multi-Attribution Causality Scale and General Self-Efficiency Scale, the data of 683 nursing undergraduates from two universities in China were collected. Moreover, path analysis for structural equation modeling via AMOS 26.0 to evaluate mediation path model.ResultsPositive parenting style was negatively associated with academic procrastination (r = –0.350) and negative parenting style was positively associated with academic procrastination (r = 0.402). Positive parenting style directly or indirectly predicted academic procrastination through the mediating effect of internal attributional style (β = –0.10, 95% CI: –0.18 to –0.04) and self-efficacy (β = –0.07, 95% CI: –0.11 to –0.03), and this mediating effect accounted for 41.46% of the total effect. Positive parenting style directly or indirectly predicted academic delay through the mediating effect of external attributional style (β = 0.12, 95% CI: 0.07 to 0.17) and self-efficacy (β = 0.05, 95% CI: 0.03 to 0.08), and this mediating effect accounted for 42.5% of the total effect. In addition, causal attribution and self-efficacy of nursing students play a chain intermediary role between parenting style and academic procrastination.ConclusionParents should give students more care and autonomy and reduce control. In addition, educators should give students attribution training, which is helpful to improve students’ self-efficacy and reduce academic procrastination.
Association of frailty with cognitive impairment and functional disability in older adults with affective disorders: a brief research report
Authors: Monteiro Ariane M. , Borges Marcus K. 
Published: July 2023

IntroductionThe Clinical-Functional Vulnerability Index (IVCF-20) is a validated multidimensional instrument that has been used in Brazil to evaluate functional disability in frail older adults. The main aim of this study was to assess frailty using this novel screening tool. In addition, to investigate whether frailty was associated with cognitive impairment and functional disability in older adults with affective disorders.MethodsParticipants included were over 60 years old, with affective disorders (depressive or anxiety disorders), from two specialized outpatient clinics. The sample was comprised of 46 patients (30% of a total from 153). The following instruments were applied: Clock Drawing Test (CDT), Mini Mental State Examination (MMSE); Verbal Fluency Test (VFT); Pfeffer Questionnaire or Functional Assessment Questionnaire (FAQ); Katz Index; Geriatric Depression Scale (GDS-15); Geriatric Anxiety Inventory (GAI), and IVCF-20 as well as sociodemographic and clinical questionnaires. The association between the variables of interest was estimated using Spearman correlation.ResultsThis study found a negative correlation between frailty and cognitive decline (MMSE; rs = −0.58; p &lt; 0.001); (VFT; rs = −0.60; p &lt; 0.001); (CDT; rs = −0.47; p = 0.001) and a positive correlation between frailty and depressive symptoms (GDS-15; rs = 0.34; p = 0.019) as well as disability for IADLs (FAQ; rs = 0.69; p &lt; 0.001). However, there was no statistical difference in the association between frailty and anxiety symptoms (GAI; rs = 0.24; p = 0.103) or disability for BADLs (Katz; rs = −0.02; p = 0.895).DiscussionOur data support that the associations between frailty, cognitive and functional disability are prevalent issues in Psychogeriatrics. Assessing frailty in a multidimensional context is essential using a rapid assessment frailty tool in clinical practice.
A systematic narrative review of extrinsic strategies to improve affective responses to exercise
Authors: Jones Leighton , Zenko Zachary 
Published: July 2023

BackgroundExtrinsic strategies affect the exercise experience but fall outside the frequency, intensity, time, and type (i.e.,dose-determining) principles. To our knowledge, no systematic review has focused on extrinsic strategies to influence the affective responses to exercise. The objective was to identify extrinsic strategies that seek to influence affective responses during exercise and other motivationally relevant variables including post-exercise momentary affective valence, remembered and forecasted pleasure, and enjoyment.MethodsFor inclusion, eligible articles reported peer-reviewed original research, used acute bouts of exercise, and used a dimensional approach for measuring affective responses or measured enjoyment post-exercise. Web of Science, PubMed, and PsychINFO databases were last searched on 10th September 2021. Quality assessment was completed following the Effective Public Health Practice Project approach. Results were presented using a narrative synthesis.Results125 studies were included with sample descriptions, study design (extrinsic strategies, mode, type, intensity, and duration), measurement details, and results summarised for each study.Conclusions71% of studies were categorised as Weak according to the quality assessment tool with sampling practices (self-referred participants) and poor reporting of participant withdrawals/drop-outs the predominant reasons for Weak ratings. A wide variety of extrinsic strategies were reported with music, music videos, immersive virtual reality, outdoor exercise, caffeine, high-to-low pattern of exercise intensity, self-selected exercise intensity, and manipulation of self-efficacy offering promise as suitable strategies to positively change how people feel during exercise.Systematic Review Registrationhttps://osf.io/jbh8v/.
Use of a neuro-evacuation device for the endoscopic removal of third ventricle colloid cysts
Authors: Peron Stefano , Galante Nicola , Creatura Donato , Sicuri Giovanni Marco , Stefini Roberto 
Published: July 2023

BackgroundColloid cysts are benign tumors usually located at the level of the foramen of Monro and account for approximately 1% of all intracranial tumors. Endoscopic surgical treatment represents the approach of choice for removal of these tumors and is usually preferred over transcortical or transcallosal microsurgical approaches. Our purpose is to demonstrate the feasibility of endoscopic removal of colloid cysts using a novel aspiration and fragmentation system, currently designed for evacuation of cerebral hematomas.MethodsWe performed an evaluation of the results obtained in patients with symptomatic colloid cysts of the third ventricle operated on using an endoscopic neuroevacuation system (Artemis Neuro Evacuation Device, Penumbra, Alameda, California, USA) between April 2020 and April 2022. Instrumentation and surgical technique are described in detail. All patients underwent postoperative MRI to assess the extent of cyst removal.ResultsFive patients were included in our study. The predominant symptom at onset was headache. No intraoperative complications related to the technology in use occurred. The surgical time for the cyst removal was significantly shorter than removal via a standard endoscopic technique (80 vs. 120 min). Removal was complete, both content and capsule of the cyst, in all patients. In all cases there was a complete regression of the previously complained symptoms.ConclusionThe Artemis Neuro Evacuation Device has proved to be effective and safe in removal of colloid cysts of the third ventricle and may be proposed as a possible alternative or as a complement of the standard instruments routinely used in neuroendoscopy.
PERENCANAAN DISTRIBUSI PENERANGAN UNTUK RUANGAN DI ATAS KAPAL TB LIBERTY 217 GT MENGGUNAKAN METODE ZONAL CAVITY
Authors: Suardi Suardi , Pawara Muhammad Uswah , Alamsyah Alamsyah , Nugraha Arifuddin Andi Mursid , Mahmuddin Faisal , Clara Sherly 
Published: July 2023

Perencanaan kelistrikan kapal harus dilakukan secara cermat dan akurat karena akan berpengaruh terhadap besar daya generator yang akan digunakan. Generator kapal dirancang untuk mampu mendistribusikan listrik untuk kebutuhan power (pompa), Penerangan (Lightning), Komunikasi dan Navigasi untuk berbagai kondisi pelayaran. Sama halnya dengan kapal lainnya, TB Liberty juga memerlukan distribusi tenaga dari generator untuk suplai kebutuhan listrik di atas kapal khususnya untuk penerangan kapal. Tujuan dari penelitian ini adalah untuk mengetahui besaran daya listrik yang dibutuhkan untuk distribusi penerangan diatas kapal dengan menggunakan lampu Light-Emitting Diode (LED). Metode yang digunakan adalah metode zonal cavity dengan konsep dasar membagi setiap ruangan menjadi tiga bagian yaitu height ceiling cavity (hcc), height room cavity (hrc), dan height floor cavity (hfc) serta penentuan nilai iluminasi sesuai dengan standar yang telah di tetapkan oleh American Bureau of Shipping (ABS). Hasil penelitian menunjukkan bahwa besar beban listrik untuk distribusi penerangan pada kapal TB Liberty dengan menggunakan lampu LED yaitu deck buttom plane sebesar 0.633 Kw, pada main deck sebesar 0.6625 Kw dan pada geladak navigasi didapatkan sebesar 0.238 Kw. Penelitian ini mampu menjadi rujukan dalam penentuan kelistrikan di atas kapal khususnya untuk instalasi penerangan kapal.
Preliminary Design Kapal type Lambung Deep Displacement untuk Wisata Panorama Bawah Laut Kepulauan Derawan
Authors: Siswanti Heni , Meilinda Maulidia , Meilinda Maulidia , Musta'in Muhammad , Musta'in Muhammad , Permata Tristiandinda , Permata Tristiandinda 
Published: July 2023

Salah satu upaya dalam mendukung pengembangan IKN di Penajam Paser Utara adalah pengembangan wilayah di sekitarnya, seperti potensi wisata alam, sejarah dan budaya. Wilayah wisata Kepulauan Derawan di Kabupaten Berau, Kalimantan Timur termasuk dalam kawasan sekitar yang layak dikembangkan. Dalam rangka menyiapkan fasilitas wisata yang memadai dan kompetitif untuk wisata panorama bawah laut wilayah tersebut, maka pada penelitian ini didesain kapal wisata type deep displacement single hull dengan kapasitas penumpang maksimal 18 orang. Proses preliminary design diawali dengan penentuan ukuran utama menggunakan metode regresi linier. Kemudian dilanjutkan dengan desain bentuk kapal berupa Lines Plan, sistem penggerak kapal, general arrangement dan perhitungan stabilitas kapal. Kapal yang didesain memiliki ukuran panjang 13.7 m, lebar 4.6 m, tinggi geladak 3.8 m dan sarat maksimum 1.94 m. Kapal dilengkapi dengan motor penggerak type outboard dengan daya 2 x 90 HP, untuk dapat berlayar dengan kecepatan 6-9 knot. Lambung kapal didesain dapat tercelup dengan sarat tinggi, supaya penumpang dapat melihat panoirama bawah laut dari sisi kapal yang dilengkapi dengan jendela transparan. Sistem pengaturan sarat kapal memanfaatkan sistem ballat utama dan ballast bantu. Kapal ini memiliki range stabilitas sampai dengan kemiringan 0-90 derajat, dengan periode oleng sebesar 3.18 detik.