bluuebunny/crossref_metadata_2025_split huggingface dataset:
Presenze monetali del II secolo d.C. ad Ostia antica
Authors: Spagnoli Emanuela 
Published: June 2023

Si presenta lo studio condotto su un complesso di evidenze numismatiche, edite e inedite, che consente di delineare alcuni degli aspetti del circuito economico-monetario di Ostia nel corso del II secolo. La base di dati è elaborata sul nucleo delle monete inquadrabili tra il principato di Nerva e Caracalla anteriforma (97-211 d.C.). Questa documentazione trae origine da interventi di scavo programmati o di emergenza e/o da ritrovamenti sporadici nel comparto urbano, a partire dagli inizi del secolo scorso.
La reconstruction du lieu d’origine. L’exemple de la Pequeña Habana à Miami, Floride
Authors: Rouhaud Aline 
Published: June 2023

À travers l’exemple de la Petite Havane à Miami en Floride, cet article s’intéresse à la reproduction du lieu d’origine par les communautés immigrées en terre d’accueil. L’exil des Cubains s’étale sur une trentaine d’années environ et malgré de nombreuses disparités entre les Cubains des années soixante et ceux des années quatre-vingt, la communauté s’enracine dans un même quartier “ethnique” qui reflète la nostalgie d’une île pré-castriste irrémédiablement disparue. La Petite Havane est plus qu’un espace physique elle représente un rêve, un substitut de La Havane et un référent identitaire pour tout Cubain vivant aux États-Unis.
De l’accompagnement des immigrés italiens à la défense internationale des migrants :
Authors: Chelini-Pont Blandine , Ferrière Alexis Artaud de La 
Published: June 2023

Fondée à la fin du xixe siècle pour ancrer les émigrants italiens dans leur sentiment national et leur foi catholique, la Congrégation des Missionnaires de Saint Charles (surnommée les Scalabriniens) s'est progressivement adaptée à l'évolution des conditions dominantes dans le champ des migrations internationales. Au fur et à mesure que la population migrante s'est diversifiée et que le travail de soutien et d'expertise auprès des migrants s'est professionnalisé, la Congrégation elle-même s'est internationalisée et sécularisée. Dépassant sa propre spécificité italienne et catholique, elle s'est investie de manière croissante dans la défense profane des migrants de toutes origines.
L’Opera Bonomelli en guerre.
Authors: Buzzi Pierre-Louis 
Published: June 2023

Parmi toutes les mobilités que la Première Guerre mondiale entraîne, celles des retours d’Italiens en Italie à l’aube du conflit sont d’une première importance : 470 000 Italiens rentrent ainsi dans leur pays d’origine en l’espace de quelques mois. Ces retours, inattendus et précipités, ne peuvent bien se dérouler que grâce au concours de diverses institutions publiques et privées dont l’Opera Bonomelli. Cette association fondée quelques années plus tôt opérait alors dans un grand nombre de pays d’émigration ainsi qu'en Italie. Elle un acteur majeur du rapatriement des migrants italiens, en accompagnant ces derniers jusqu’à la mobilisation italienne du printemps 1915.
HIV-1 Tat Upregulates TREM1 Expression in Human Microglia
Authors: Campbell Grant R , Rawat Pratima , To Rachel K , Spector Stephen A 
Published: June 2023

Abstract
Because microglia are a reservoir for HIV and are resistant to the cytopathic effects of HIV infection, they are a roadblock for any HIV cure strategy. We have previously identified that triggering receptor expressed on myeloid cells 1 (TREM1) plays a key role in human macrophage resistance to HIV-mediated cytopathogenesis. In this article, we show that HIV-infected human microglia express increased levels of TREM1 and are resistant to HIV-induced apoptosis. Moreover, upon genetic inhibition of TREM1, HIV-infected microglia undergo cell death in the absence of increased viral or proinflammatory cytokine expression or the targeting of uninfected cells. We also show that the expression of TREM1 is mediated by HIV Tat through a TLR4, TICAM1, PG-endoperoxide synthase 2, PGE synthase, and PGE2-dependent manner. These findings highlight the potential of TREM1 as a therapeutic target to eradicate HIV-infected microglia without inducing a proinflammatory response.
Third and Fourth Vaccine Doses Broaden and Prolong Immunity to SARS-CoV-2 in Adult Patients with Immune-Mediated Inflammatory Diseases
Authors: Cheung Michelle W , Dayam Roya M , Shapiro Janna R , Law Jaclyn C , Chao Gary Y C , Pereira Daniel , Goetgebuer Rogier L , Croitoru David , Stempak Joanne M , Acheampong Lily , Rizwan Saima , Lee Jenny D , Jacob Liz , Ganatra Darshini , Law Ryan , Rodriguez-Castellanos Victoria E , Kern-Smith Madeline , Delgado-Brand Melanie , Mailhot Genevieve , Haroon Nigil , Inman Robert D , Piguet Vincent , Chandran Vinod , Silverberg Mark S , Watts Tania H , Gingras Anne-Claude 
Published: June 2023

Abstract
Previous studies have reported impaired humoral responses after SARS-CoV-2 mRNA vaccination in patients with immune-mediated inflammatory diseases (IMIDs), particularly those treated with anti-TNF biologics. We previously reported that IMID patients diagnosed with inflammatory bowel disease, psoriasis, psoriatic arthritis, ankylosing spondylitis, or rheumatoid arthritis exhibited greater waning of Ab and T cell responses than healthy control subjects after SARS-CoV-2 vaccine dose 2. Fewer data are available on the effects of third and fourth doses. This observational cohort study collected plasma and PBMCs from healthy control subjects and untreated or treated patients with IMIDs prevaccination and after one to four doses of SARS-CoV-2 mRNA vaccine (BNT162b2 or mRNA-1273). SARS-CoV-2–specific Ab levels, neutralization, and T cell cytokine release were measured against wild-type and Omicron BA.1 and BA.5 variants of concern. Third vaccine doses substantially restored and prolonged Ab and T cell responses in patients with IMIDs and broadened responses against variants of concern. Fourth-dose effects were subtle but also prolonged Ab responses. However, patients with IMIDs treated with anti-TNF, especially patients with inflammatory bowel disease, exhibited lower Ab responses even after the fourth dose. Although T cell IFN-γ responses were maximal after one dose, IL-2 and IL-4 production increased with successive doses, and early production of these cytokines was predictive of neutralization responses at 3–4 mo postvaccination. Our study demonstrates that third and fourth doses of the SARS-CoV-2 mRNA vaccines sustain and broaden immune responses to SARS-CoV-2, supporting the recommendation for three- and four-dose vaccination regimens in patients with IMIDs.
Assessment of surface topographic changes of nickel–titanium rotary endodontic file at repeated usage: An in vitro study
Authors: Viswas E. , Krishna VSS , Sridevi E. , Sankar A. J. Sai , Sankar K. Siva , Nagesh B. 
Published: June 2023

ABSTRACT

Aim:
The current in vitro study aimed to assess the surface topography of Protaper gold NiTi files and compare changes in surface topography before and after root canal preparation in straight, moderately, and severely curved root canals.

Methods:
In this study, thirty Protaper gold S1 files were selected. These were divided into three groups of 10 each and were used to prepare 440 straight, moderately, and severely curved root canals. Optical profilometry was used to perform qualitative evaluations of file surfaces before and after root canal preparation at specified intervals. The statistical analysis was performed using the Mann–Whitney U-test for comparing two groups, the Friedman test for comparing within groups, the Kruskal–Wallis analysis of variance for multigroup comparisons, and the Bonferroni test for multiple pairwise comparisons.

Results:
The surface irregularities in the form of cracks and microcavities were higher in the used files when compared to the unused files. Similarly, the files used in severely curved canals exhibited more surface alterations at less no of uses when compared to the files used in straight and moderately curved canals. The difference obtained was statistically significant, that is, P = 0.000.

Conclusion:
From the findings, it was concluded that the file separation has been preceded with surface deterioration as a result of repeated cycles of cyclic fatigue.
A comparative evaluation of the dentinal microcracks formed and propagated during the removal of gutta-percha using hand and three rotary retreatment file systems: A micro-computed tomography study
Authors: Sanjeev Srivastava , Gupta Rita , Sandeep Dubey , Tanu Tewari , Namita Shukla , Arohan Singh 
Published: June 2023

ABSTRACT

Aim:
This micro-computed tomography (micro-CT) study aims to quantitatively analyze the dentinal microcracks formed and propagated after endodontic retreatment using different file systems.

Methods:
Forty extracted mandibular premolars were selected. Biomechanical preparation was done using ProTaper Next rotary files followed by obturation using lateral compaction technique. All specimens were randomly divided into four groups (n = 10) and scanned under 1172; Micro-CT (Skyscan Bruker, Kontich, Belgium). After scanning, the first group was retreated using Hedstrom (H) files (Dentsply Maillefer, Ballaigues, Switzerland), the second group with Gutta Percha Remover (GPR) files (Mani Inc., Japan), the third group with Endostar RE Re Endo Rotary system (RE Endo files) (Endostar RE, Poland), and fourth group with ProTaper Universal Retreatment (PTUR) files (Dentsply Maillefer, Ballaigues, Switzerland). A micro-CT scan was repeated of each sample to observe the newly formed and propagated microcracks. The micro-CT scans before and post retreatment were then evaluated using CT-analyzer software. Data were compared using the Chi-square test.

Results:
New microcracks formed post retreatment were maximum in the RE Endo group followed by the PTUR group, GPR group, and least in the H file group. Propagation of existing microcracks after retreatment was maximum in the RE Endo group followed by nearly similar in both the GPR group and PTUR group and least in the H file group. On comparing the frequency distribution of the newly formed and propagated microcracks, the Chi-square test showed similar distribution among all four groups, which was found statistically insignificant (P > 0.05).

Conclusion:
GPR rotary instrument group created the least new microcracks among tested retreatment rotary files. However, the propagation of microcracks was found comparable with the PTUR files.
Mandibular foramen location and its implication to the inferior alveolar nerve block: A retrospective study
Authors: Sanwatsarkar Gauri , Agarwal Rolly , Hiremath Hemalatha , Kulkarni Sadanand , Agarwal Jatin , Hiremath Vishwanath 
Published: June 2023

ABSTRACT

Aim:
This study was carried out to identify differences in the parameters for locating mandibular foramen (MF) in the central Indian population and the recommended guidelines for the administration of inferior alveolar nerve block (IAN) as mentioned in the dental literature.

Methods:
Eighty high-resolution full volumes cone-beam computed tomography (CBCT) scans were randomly selected from the radiology database and the scans were rendered, viewed, and measured using the on-demand volumetric imaging software (Anatomage, San Jose, CA). The parameters used in locating the MF/IAN complex were the horizontal distance from the mandibular notch to the midpoint of MF (H); vertical distance from the level of the mandibular occlusal plane to the center of MF (V) and the angle from the contralateral premolar contact area to the MF.

Results:
Paired t-test was applied. The mean horizontal distance from the mandibular notch to MF was 22.36 ± 2.60 mm in males and 21.05 ± 3.57 mm in females. The mean vertical distance to the occlusal plane was 10.23 ± 4.57 mm in males and 7.42 ± 4.96 mm in females, with a significant difference between the genders (P < 0.05). The mean value for the angulation for the occlusal plane was 39.28° ±5.23° and 37.35° ±3.72° in males and females, respectively.

Conclusion:
Ethnicity and gender influence the location of the MF/IAN complex. The utilization of long needles, orienting the syringe barrel at an angulation slightly <45° and approximately 10 mm above the mandibular occlusal plane can aid in successfully administering the IAN block.
Evaluation of postoperative pain with cryotherapy in teeth with symptomatic irreversible pulpitis with symptomatic apical periodontitis after single-visit endodontics: A randomized clinical study
Authors: Shah Vidhi Rakesh , Shah Nimisha Chinmay , Kishan Karkala Venkappa , Kothari Meghna Anil , Patel Jaimini Jigar , Patel Shrey Navin 
Published: June 2023

ABSTRACT

Aim:
The aim of the study was to clinically evaluate the postoperative pain following use of cryotherapy in teeth with symptomatic irreversible pulpitis and symptomatic apical periodontitis after single‐visit-endodontics.

Methods:
After institutional ethical approval (SVIEC/ON/Dent/SRP/18115) and informed consent, a total of 120 patients were included as per inclusion and exclusion criteria. Patients with single-rooted, mature teeth having symptomatic irreversible pulpitis with symptomatic apical periodontitis were included in the study. All the enrolled individuals were randomly divided by computer randomization into two groups: Group A – normal saline (n = 60) and Group B – cryotherapy (n = 60). Endodontic access cavity along with cleaning and shaping was performed under isolation. In Group A, irrigation was done with normal saline for 5 min. In Group B, 2.5°C cold saline was used for 5 min. In both the groups, obturation and postendodontic restoration were performed at the same visit. An evaluation was done by the blinded evaluator using a modified Verbal Rating Scale at 24 h and 48 h. In this study, both patients and evaluators were blinded. Paired t-test and independent t-test were used with SPSS 18.0 version. P < 0.05 was considered statistically significant.

Results:
Both at 24 and 48 h, cryotherapy showed a highly statistically significant difference (P < 0.000) than normal saline irrigation in the reduction of postoperative pain after single-visit endodontic treatment.

Conclusion:
Final irrigation with 2.5°C cold saline can result in a significant reduction in postoperative pain as compared to that of normal saline after single-visit endodontics in single-rooted teeth with symptomatic irreversible pulpitis with symptomatic apical periodontitis.
A cross-sectional study of the mental health burden among COVID-19 survivors
Authors: Nongpiur Arvind , Barman Bhupen , Syiem Kimberly , Mawiong Andreecia Mn , Anand Naveen , Nune Arvind 
Published: June 2023

ABSTRACT

Introduction:
Coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on mental health, including stress, anxiety, and depression. This study aimed to assess the incidence and severity of mental health issues among individuals diagnosed with COVID-19 infection.

Methods:
A semi-structured proforma for socio-demographic and clinical parameters was used to collect cross-sectional hospital-based data of subjects who tested positive for COVID-19 infection. The Modified Fatigue Impact Scale (MFIS), Hospital Anxiety and Depression Scale (HADS), and Perceived Stress Scale (PSS) were used to assess the presence of physical, psychological, and cognitive symptoms. The presence of anxiety, depression, and stress was based on the cut-off scores for HADS-A (≥8), HADS-D (≥8), and PSS (≥14), respectively.

Results:
A total of 101 patients comprising 39 (38.6%) males were recruited. Compared to nuclear families, we observed that patients living in joint families had significantly greater severity scores for fatigue [MFIS (p = 0.04)], anxiety [HADS-A (p = 0.004)], depression [HADS-D (p = 0.004)], and stress [PSS (p = 0.02)]. Based on the cut-off scores, we found that 44 (43.6%) patient had anxiety, 41 (40.6%) had depressive, and 72 (71.3%) had moderate to high stress symptoms, respectively. We also observed significantly greater fatigue and anxiety scores, that is, MFIS (p = 0.008) and HADS-A (p = 0.03) in those who received oxygen therapy compared to those who did not. The subjects who received corticosteroids were older (p = 0.01) and had significantly higher stress scores [PSS (p < 0.001)]. The study showed that patients who were assessed more than 3 months post-COVID-19 infection had higher fatigue and depression scores; however, the difference did not reach statistical significance (MFIS P = 0.058; HADS P = 0.059).

Conclusion:
Our study confirms that COVID-19 infection can cause various adverse mental health issues. Mitigating the hazardous effects of COVID-19 pandemic on mental health should be a top priority for public health to prevent long-term complications.
Depression and anxiety symptoms, subjective well-being, and happiness among Indian high school students
Authors: Park Suh Jung , Wasil Akash R. , Gillespie Sarah , Shingleton Rebecca M. , Weisz John R. , DeRubeis Robert J. 
Published: June 2023

ABSTRACT

Background:
Mental health problems cause significant distress and impairment in adolescents worldwide. One-fifth of the world’s adolescents live in India, and much remains to be known about their mental health and wellbeing.

Aim:
In this preregistered study, we aimed to estimate the rates of depressive and anxiety symptoms, examine their relationship with indicators of wellbeing, and identify correlates of mental health among Indian adolescents.

Methods:
We administered self-report measures of depressive symptoms (PHQ-9), anxiety symptoms (GAD-7), wellbeing (WEMWBS), and happiness (SHS) to 1,213 Indian adolescents (52.0% male; M
age = 14.11, SD
age = 1.48).

Results:
Findings from the PHQ-9 (M = 8.08, SD = 5.01) and GAD-7 (M = 7.42, SD = 4.78) indicated high levels of depressive symptoms and anxiety symptoms. Thirty seven percent of the sample scored above the clinical cutoff for depressive symptoms, and 30.6% scored above the cutoff for anxiety symptoms. Although measures of mental health symptoms (PHQ-9 and GAD-7) were associated with measures of wellbeing and happiness (WEMWBS and SHS), these associations were only modest (Correlation < 0.45). Female students reported higher symptoms (and worse wellbeing) compared to male students, and older students reported higher symptoms (and worse wellbeing and happiness) compared to younger students.

Conclusion:
This study highlights the high prevalence of depressive symptoms and anxiety symptoms among Indian high school students. Symptom measures correlated only modestly with measures of wellbeing and happiness, suggesting that wellbeing and happiness reflect more than the absence of internalizing symptoms. Future research is needed to identify effective and appropriate ways to promote mental health and wellness among Indian students.
Hyperthermia Improves Doxorubicin-Based Chemotherapy by Activating Mitochondrial Apoptosis in Bladder Cancer
Authors: Chang An-Chen , Chen Po-Chun , Chen Hung-En , Tsai Te-Fu , Chou Kuang-Yu , Ho Chao-Yen , Hwang Thomas I-Sheng 
Published: June 2023

Purpose:
Although intravesical chemotherapy has several antitumoral benefits, it can also have severe side effects. The development of novel therapeutic approaches for bladder cancer (BC) is thus warranted. Hyperthermia (HT) is a widely applicable adjuvant therapy in various cancers. Therefore, this study investigated the effect of HT on improving the chemosensitivity of BC.

Materials and Methods:
The BC cell lines 5637 and T24 were cultured and treated with HT (43°C) for 24 h. Then, cell viability and survival were assessed using resazurin reagent and colony formation assay, respectively. Western blot assay was used to analyze the levels of Bax, Bcl-2, cleaved caspase-3, and cleaved poly (ADP-ribose) polymerase (PARP) protein expression. Mitochondria degradation was observed by MitoTracker Green staining.

Results:
In BC cells, HT co-administered with various concentrations of doxorubicin significantly inhibited cell viability and survival. Moreover, HT combined with doxorubicin promoted mitochondrial apoptosis, which caused Bax upregulation and Bcl-2 downregulation. Levels of cleaved caspase-3 and PARP protein expression were also elevated after co-treatment.

Conclusion:
Taken together, HT improved the chemosensitivity of BC cells to doxorubicin. HT combined with chemotherapy further activated mitochondrial apoptosis in BC cells. The findings suggested that HT may serve as a potential adjunctive treatment for BC that is ready to be applied clinically.
The Effect of Electrolyzer Installation on 4-Stroke Modified Injection Motorcycle on Fuel Consumption and Exhaust Gas
Authors: Wahyudi Ridho , Purwanto Wawan , Maksum Hasan , Setiawan M. Yasep , Sampurno Yoga Guntur 
Published: June 2023

The increasing population of motorbikes has an impact on fuel needs and the resulting increase in exhaust emissions. The electrolyzer has an effect on fuel consumption and gasoline exhaust of a modified 4-stroke motorbike. This research is experimental research, starting with designing and making the tools to be studied, then conducting research. As a result, there was a decrease in fuel consumption of 31.36% at 2000 RPM rotation, 8.73% at 4000 RPM engine speed, and 15.48% at 6000 RPM rotation. While exhausting emissions, there was a decrease in CO of 47.37%, an increase in h22o of 24.37%, and a decrease in HC of 45.11% at 2000 RPM rotation. The 4000 RPM rotation decreased CO by 89.11%, CO2 increased by 35.48%, and HC decreased by 36.98%. The 6000 RPM rotation decreased CO by 41.67%, CO2 increased by 17.26% and HC decreased by 6.92%.
Semakin banyak populasi sepeda motor berdampak pada kebutuhan bahan bakar dan meningkatnya emisi gas buang yang dihasilkan. Elektroliser berpengaruh pada konsumsi bahan bakar dan gas buang sepeda motor 4 langkah modifikasi injeksi. Penelitian ini merupakan penelitian eksperimen, dimulai dengan merancang dan membuat alat yang akan diteliti, kemudian dilakukan penelitian. Hasilnya, terjadi penurunan konsumsi bahan bakar sebesar 31.36% pada putaran 2000 RPM, 8.73% pada putaran mesin 4000 RPM dan 15.48% pada putaran 6000 RPM. Sedangkan emisi gas buang, terjadi penurunan CO sebesar 47.37%, kenaikan CO2 sebesar 24.37% dan penurunan HC sebesar 45.11% pada putaran 2000 RPM. Putaran 4000 RPM terjadi penurunan CO sebesar 89.11%, kenaikan CO2 sebesar 35.48%, dan penurunan HC sebesar 36.98%. Putaran 6000 RPM terjadi penurunan CO sebesar 41.67%, kenaikan CO2 sebesar 17.26% dan penurunan HC sebesar 6.92%.
Analysis of the Relationship between Road Slope and Total Resistance to Fuel Consumption of Sany Skt 90s Dump Truck
Authors: Prabowo Heri , Febriani Clara 
Published: June 2023

The purpose of this study was to determine the relationship between road slope and total resistance to Dump Truck fuel consumption. Based on the calculations, the relationship between road slope and fuel consumption is obtained using the regression equation for when loaded Y = 0.0817X +1.831 and when empty Y = 0.0344X + 0.787. While the relationship between total resistance and fuel consumption when loaded with the regression equation Y = 0.0012X +1.8229 when loaded and Y = 0.001X + 0.5789 when empty. The recommended recommendation to reduce dump truck fuel consumption is by improving the road slope according to the standard, which is 8%. After repairing the road slope, the company can save fuel consumption of 87.07 liters/day for 14 dump trucks with an estimated savings of Rp.1,105,764.87 per day.
Tujuan penelitian ini untuk mengetahui hubungan kemiringan jalan dan total resistance terhadap konsumsi bahan bakar Dump Truck. Berdasarkan perhitungan, didapatkan hubungan kemiringan jalan terhadap konsumsi bahan bakar menggunakaan persamaan regresi untuk saat bermuatan Y= 0,0817X +1,831 dan ketika kosong Y= 0,0344X + 0,787. Sedangkan hubungan total resistance terhadap konsumsi bahan bakar ketika bermuatan dengan persamaan regresi Y = 0,0012X +1,8229 ketika bermuatan dan Y= 0,001X + 0,5789 ketika kosong. Rekomendasi yang disarankan untuk dapat menurunkan konsumsi bahan bakar dump truck adalah dengan cara perbaikan kemiringan jalan yang sesuai standar, yaitu 8%. Setelah adanya perbaikan kemiringan jalan, perusahaan dapat menghemat pemakaian bakar sebanyak 87,07 liter/hari untuk 14 unit dump truck dengan taksiran hemat sebesar Rp.1.105.764,87 per hari.