bluuebunny/crossref_metadata_2025_split huggingface dataset:
DJ STENT COLONIZATION PATTERNS: EXPLORING MICROBIAL PROFILES AND CLINICAL RELEVANCE
Authors: KUMAR J , SHAIKH NA , SAMAD A , KURD BJ , AHMED SA , ZAIDI SZ 
Published: July 2023

With the advancement of endourology, a great variety of biomaterial devices have been developed. Several studies have reported that the formation of biofilm and device infection are commonly observed manifestations that lead to urinary tract infections. An indwelling double J ureteral stent carries a significant risk; a negative urine culture does not rule out a colonized stent. Hence, assessing the extent of stent colonization without positive voided urine culture is crucial. This cross-sectional study involved 44 patients, aged between 14 to 88 years, coming to the Department of Urology at Indus Hospital Karachi to remove DJ stents from April 2019 to October 2019. The samples were collected through a non-probability consecutive technique. Urine samples, before removal of the stent along with distal portions of the DJ stent, were sent for cultural analysis to study bacteriuria and stent colonization. The whole data was analyzed on SPSS version 22.0. The study found that five patients (11.4%) had colonization of the distal end of the DJ stent, and Burkholderia cepacia was the most common microorganism. However, n=31; 70.4% of patients had colonization in post-DJ stent urine, and Pseudomonas was the most common microorganism (n=14; 45.2%). Stent colonization had no significant association with age, gender, and positive urine culture. Most colonized stents were asymptomatic. Despite these observations, it is critical to emphasize that using DJ stents is still a generally recognized and safe treatment. Future studies should look at other aspects that colonization patterns may impact in improving the safety and management of DJ stent use.
ABORDAJE DE LA SEXUALIDAD EN PERSONAS CON LESIÓN MEDULAR TRAUMÁTICA DESDE LA TERAPIA OCUPACIONAL
Authors: Aramburu Josefina 
Published: July 2023

El presente artículo tiene como objetivo dar a conocer a través de diversos estudios de casos, la importancia del abordaje de Terapia Ocupacional en el acompañamiento de la sexualidad en personas que, por diversas circunstancias, la lesión medular irrumpió en sus vidas produciendo cambios en la manera de realizar sus ocupaciones, entendidas estas como diversos tipos de actividades diarias en las que las personas participan.
Pengaruh Gaya Kepemimpinan Dan Karakteristik Individu Terhadap Kinerja Satuan Tugas Lombok Batalyon Zeni Tempur 9/1 Komando Cadangan Strategis Angkatan Darat
Authors: Dwi Putra Umaroh  
Published: July 2023

Sebuah kinerja dari anggota Sebuah Satgas Militer pada dasarnya adalah sebuah tugas dan pekerjaan yang diberikan oleh instasi yang tentu pekerjaan yang diberikan akan disesuaikan dengan kemampuan dari individu tersebut, Perbedaan karakter dan latar belakang yan dimiliki oleh anggota Satgas militer tersebut tentunya dipengaruhi juga oleh peran pimpinan dalam mengatur MSDM yang ada dalam organisasinya tersebut, sehingga dalam penelitian ini akan dibahas terkait dengan pengaruh gaya kepemimpinan, pengaruh karakteristik individu dan pengaruh gaya kepemimpinan dan karakteristik individu secara bersama-sama terhadap kinerja satuan tugas di Lombok Batalyon Zeni Tempur 9/1 Komando Cadangan Strategis Angkatan Darat, penelitian ini menggunakan metode kuantitatif, dimana hasil penelitian menunjukan bahwa Pengaruh Kepemimpinan Komandan Batalyon berpengaruh sebesar 0,467 terhadap variabel Disiplin Prajurit di Batalyon Zeni Tempur 9/1 Komando Cadangan Strategis Angkatan Darat. Pengaruh dapat bersifat positif dan dapat pula bersifat Negatif. Model kepemimpinan yang dilaksanakan oleh Batalyon Zeni Tempur 9/1 Komando Cadangan Strategis Angkatan Darat adalah model kepemimpinan yang berorientasi pada pegawai. Model kepemimpinan ini ditandai dengan perilaku pemimpinnya yang memandang penting hubungan baik dan manusiawi dengan bawahannya dan Bentuk disiplin prajurit yang rendah dipengaruhi oleh ancaman pengaruh lingkungan di luar Kesatuan ditambah dengan kurangnya pengawasan dan pengendalian dari Komandan Batalyon, oleh karena itu perlu dilakukan tindakan defensive yang dapat meminimalisir penyimpangan-penyimpangan yang akan merugikan nama baik Kesatuan dan menurunya moral serta etika prajurit.

Kata kunci: Pengaruh Gaya Kepemimpinan, Karakteristik Individu, Kinerja satuan, Kinerja
BEBAN DAN STRESS KERJA PADA BULOG
Authors: Ramadhan Dendy Fazrul , Manafe Leonard Adrie 
Published: July 2023

Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan pengaruh dan akibat stres kerja dan beban kerja pada Bulog. Metode yang digunakan penelitian ini yaitu metode kualitatif deskriptif dengan menggali informasi melalui tahapan wawancara mendalam terhadap enam orang informan yang berasal dari pegawai Bulog. Selain wawancara, peneliti juga melakukan observasi lapangan dan penarikan dokumentasi. Teknik wawancara dilakukan dengan memberikan beberapa pertanyaan terstruktur. Hasil penelitian menunjukkan bahwa setiap pekerja mengalami stress kerja dan beban kerja yang tinggi. Lebih khusus pada faktor tekanan yang dihadapi meliputi terdapatnya beban kerja yang tinggi, jam kerja berlebihan, terdapatnya tuntutan dari konsumen, dan kurangnya sumber daya. Bila terjadinya stres kerja pada pegawai yang disebabkan karena tingkat beban kerja semakin tinggi dan ketidakstabilan dalam pekerjaan.
Paris districts. 8th arrondissement of Paris
Authors: Brzezinski Piotr 
Published: July 2023

8. Dzielnica Paryża – jest nie tylko domem dla niektórych z najbardziej prestiżowych, a nawet charakterystycznych miejsc francuskiej stolicy, takich jak Pola Elizejskie, Łuk Triumfalny, Pałac Elizejski czy kościół La Madeleine, ale jest także gospodarczym motorem stolicy. Jest to również strategiczne skrzyżowanie dróg transportu publicznego ze stacją Saint-Lazare. 5 z 11 uznanych paryskich pałaców znajduje się w dzielnicy: Le Bristol, Crillon, George V, Plaza Athénée i La Réserve Paris. 5 z 10 paryskich restauracji, które w 2018 roku zdobyły 3 gwiazdki w przewodniku Michelin, znajduje się w dzielnicy: Alain Ducasse, Yannick Alléno, Ledoyen, ... Pomiędzy dużymi alejami wysadzanymi drzewami, budynkami o imponującej architekturze, majestatycznymi mostami ... jest wiele do odkrycia podczas spaceru po 8. dzielnicy. ... Aby zrozumieć Paryż trzeba na chwilę przystanąć.
Implementation of K-Means Clustering Technique in Banana Production of Tamil Nadu, India
Authors: Humretha S. , Gangaiselvi R. , Kannan Balaji , Rani C. Indu , Dheebakaran Ga. 
Published: July 2023

Aim: The main objectives of this study are to make use of the K-Means clustering approach to cluster the Banana data and to assist with crop yield prediction.
Study Design: One of the methods of Big Data Analytics K-Means clustering is usedto cluster the data set.
Place and Duration of Study: So far, the period 2010-2020, time series data were collected from the season and crop report, Directorate of Economics and Statistics, Chennai.
Methodology: The horticulture industry has a significant impact on India's economic development. In the globe, after China, India ranks second in terms of fruit and vegetable production. Compare to the various fruits Mango and banana are one of the most abundant fruits in India. So, the Banana dataset were collected and dataset were clustered using the K-Means clustering technique and the optimum number of clusters were identify using the elbow approach.
Results: According to these results from this study, there is positive relationship between the Area, Soil moisture, Maximum Temperature, Relative Humidity and negative relationship between Rainfall, Wind Speed and Minimum temperature related Banana production. Using K-Means clustering it divides the given dataset into three clusters in which cluster 3 contains high Banana production afterwards two and one.
Conclusion: The selection of the most productive clusters is going to tell farmers on where to focus their efforts while planting crops in order to enhance productivity and crop production.
Effect of Organic and Inorganic Fertilizers on the Growth and Yield of Tomato (Solanum Lycopersicum) under Protected Cultivation
Authors: Rohan  , Kerketta Anita , Bahadur Vijay , Topno Samir E. 
Published: July 2023

The present investigation titled “Effect of organic and inorganic fertilizer on growth and yield of tomato under protected cultivation” was carried out during 2022 in Central Horticulture Research Farm of Department of Horticulture, SHUATS, Prayagraj to assess the impact of different doses of organic and inorganic fertilizer on the growth and yield of tomatoes under protected condition, as well as to analyze the economic aspects of different treatments. The experiment was conducted in Randomized Block Design with 10 treatments replicated thrice. The treatments were T0 Recommended dose of fertilizers (RDF), T1 75% (RDF) +25% (Vermicompost), T2 50% (RDF) + 50% (Vermicompost), T3 25% (RDF) +75% (Vermicompost), T4 75% (RDF) + 25% (FYM), T5 50 %(RDF) +50% (FYM), T6 25 %(RDF) +75% (FYM), T7 75% (RDF) + 25% (Poultry Manure), T8 50% (RDF) +50% (Poultry Manure), T9 25% (RDF) +75% (Poultry Manure). On the basis of our finding the best treatment was found to be T6 (25% RDF + 75% FYM) which was found best in terms of growth parameters and yield parameters among different treatment combinations of tomato. Also the best B:C ratio 3.84 was found in T6 (25% RDF + 75% FYM).
Lower digit length ratio and aggression in adolescents and young adults with boxer's fracture: A case‐control study
Authors: Aslan Genç Herdem , Özcan Morey Aslıhan 
Published: July 2023

AbstractRecent evidence shows that a lower second‐to‐fourth digit ratio (2D:4D), which is a sexually dimorphic trait and the indicator of prenatal testosterone exposure, may be associated with aggressive behaviors. In this cross‐sectional, case‐control study, we investigated: (1) Are the aggression and impulsivity levels and emotional problems higher? (2) Is the 2D:4D ratio lower in adolescents and young adults who presented with a fifth metacarpal neck fracture (boxer's fracture) compared to controls? (3) Is the digit ratio correlated with aggressive measures in individuals with a fifth metacarpal neck fracture? Seventy‐one consecutive patients presented with a fifth metacarpal neck fracture within the age range of 11–25 years old comprised the study group. The control group consisted of 71 age and sex‐matched subjects without a history of aggression‐related injury. The aggression, impulsiveness, and psychosocial well‐being were measured by self‐reported questionnaires. 2D:4D was measured by conventional radiography. The 2D:4D ratio was similar between groups, however, when the analyses were conducted separately for sex, females in the study group showed lower 2D:4D than females in the control group (p = 0.001). The aggression level of the study group, measured by the Buss–Perry Aggression Questionnaire was higher than the control group (p = 0.014). The impulsiveness scores on the Barratt Impulsiveness Scale‐11 were similar (p = 0.60) and the total difficulty score on the Strengths and Difficulties Questionnaire was higher in the study group (p = 0.009). A lower 2D:4D ratio significantly predicted verbal and total aggression scores (p = 0.036, p = 0.032, respectively). Our findings suggest that females with a history of aggression‐related injury have lower 2D:4D, and a lower 2D:4D is correlated with higher aggression levels in both sexes. Understanding and addressing aggression in these patients may help prevent further self‐inflicted injuries.
Increased Risk of Rheumatoid Arthritis in Patients With Asthma: A Genetic Association Study Using Two‐Sample Mendelian Randomization Analysis
Authors: Yan Jiyuan , Zhang Yi , Zhang Xiaofei , Chen Ge , Wei Daiqing , Duan Ke , Li Zheng , Peng Lin , Liu Jialin , Li Zhong , Liu Yanshi 
Published: July 2023

ObjectiveObservational studies have explored the association between asthma and some types of arthritis, including rheumatoid arthritis and osteoarthritis, but the results are largely contradictory. We aimed to investigate the causal effects of asthma on arthritis, including osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis.MethodsTwo‐sample Mendelian randomization (MR) analysis was used to investigate the causal effects of asthma on each arthritis. The genetic instruments for asthma were obtained from a large genome‐wide association study of asthma. The inverse‐variance weighted (IVW) method was used as the main analysis of MR. Bonferroni‐adjusted P value threshold was used to account for multiple comparisons.ResultsMR‐IVW analysis suggested that adult‐onset asthma (AOA) was associated with increased risk of rheumatoid arthritis. The odds ratio for rheumatoid arthritis associated with AOA and childhood‐onset asthma (COA) were 1.018 (95% confidence interval [95% CI], 1.011–1.025; P < 0.001) and 1.006 (95% CI 1.001–1.012; P = 0.046), respectively. For osteoarthritis, gout, or ankylosing spondylitis, all the MR analyses showed no significant causal effects of AOA or COA on them. We also performed a reverse MR analysis to explore the causal effects of rheumatoid on all asthma, allergic asthma, or nonallergic asthma and found no significant causal effects on them.ConclusionGenetically predicted AOA predisposes patients to an increased risk of rheumatoid arthritis but has no causal effects on osteoarthritis, gout, and ankylosing spondylitis. The result of COA on rheumatoid arthritis is suggestive of potential causal relationship but needs to be confirmed in further studies.image
A Core–Shell Nanoreinforced Ion‐Conductive Implantable Hydrogel Bioelectronic Patch with High Sensitivity and Bioactivity for Real‐Time Synchronous Heart Monitoring and Repairing
Authors: Shen Si , Zhang Jie , Han Yanni , Pu Chunyi , Duan Qixiang , Huang Jianxing , Yan Bing , You Xintong , Lin Rurong , Shen Xiaoxi , Qiu Xiaozhong , Hou Honghao 
Published: July 2023

AbstractTo achieve synchronous repair and real‐time monitoring the infarcted myocardium based on an integrated ion‐conductive hydrogel patch is challenging yet intriguing. Herein, a novel synthetic strategy is reported based on core–shell‐structured curcumin‐nanocomposite‐reinforced ion‐conductive hydrogel for synchronous heart electrophysiological signal monitoring and infarcted heart repair. The nanoreinforcement and multisite cross‐linking of bioactive curcumin nanoparticles enable well elasticity with negligible hysteresis, implantability, ultrahigh mechanoelectrical sensitivity (37 ms), and reliable sensing capacity (over 3000 cycles) for the nanoreinforced hydrogel. Results of in vitro and in vivo experiments demonstrate that such solely physical microenvironment of electrophysiological and biomechanical characteristics combining with the role of bioactive curcumin exert the synchronous benefit of regulating inflammatory microenvironment, promoting angiogenesis, and reducing myocardial fibrosis for effective myocardial infarction (MI) repair. Especially, the hydrogel sensors offer the access for achieving accurate acquisition of cardiac signals, thus monitoring the whole MI healing process. This novel bioactive and electrophysiological‐sensing ion‐conductive hydrogel cardiac patch highlights a versatile strategy promising for synchronous integration of in vivo real‐time monitoring the MI status and excellent MI repair performance.
Enzyme‐free photothermally amplified fluorescent immunosorbent assay (PAFISA) for sensitive cytokine quantification
Authors: Li Dian , He Wei , Lin Xuyan , Cui Xiaodong , Nagl Stefan , Wu Angela Ruohao , Kwok Ryan T. K. , Wu Renhua , Tang Ben Zhong 
Published: July 2023

AbstractCytokine monitoring has attracted great attention due to its significance in the diagnosis and treatment of many diseases, such as tumors, microbial infections, and immunological diseases. Enzyme‐linked immunosorbent assay (ELISA) is one of the most popular methods in cytokine detection, ascribing to the lavish signal amplification methods in the ELISA platform. In addition to classical enzymes, other signal amplifiers such as fluorescent probes, artificial nano‐enzymes, and photothermal reagents have been applied to reduce the detection limit and produce more sensitive ELISA kits. Due to the accumulative effect of heat, photothermal reagents are promising materials in the signal amplification of ELISA. However, the lack of efficient photothermal generation material at an aggregate scale may delay the further development of this area. In this contribution, based on an efficient organic photothermal aggregate material, an enzyme‐free photothermally amplified fluorescent immunosorbent assay system consisting of an assay microfluidic chip and detecting platform was developed. The photothermal nanoparticles with highly efficient photothermal conversion by harvesting energy via excited‐state intramolecular motions and enlarging molar absorptivity were successfully prepared. The detection concentration at 50 pg/mL of interleukin‐2 was achieved, realizing a signal improvement of detection limits by 20‐fold compared to that of previously reported photothermal ELISA. The microscopic imaging integrated with plane sweeping technology provided high spatial resolution and precision, indicating the potential of achieving high throughput profiling at the microscale. Moreover, as an alternative excitation source, light‐emitting diode not only provided a more affordable and miniaturized detection system but also revealed the great feasibility of intramolecular motion‐induced photothermy nanoparticles for biological analyses.
Safety and efficacy of jaktinib (a novelJAKinhibitor) in patients with myelofibrosis who are relapsed or refractory to ruxolitinib: Asingle‐arm,open‐label, phase 2, multicenter study
Authors: Zhang Yi , Zhang Qike , Liu Qingchi , Dang Huibing , Gao Sujun , Wang Wei , Zhou Hu , Chen Yuqing , Ma Liangming , Wang Jishi , Yang Haiping , Lu Binhua , Yin Hewen , Wu Liqing , Suo Shanshan , Zhao Qingwei , Tong Hongyan , Jin Jie 
Published: July 2023

AbstractRuxolitinib has demonstrated efficacy in patients with myelofibrosis (MF). However, substantial number of patients may not respond after 3–6 months of treatment or develop resistance over time. In this phase 2 trial, patients with a current diagnosis of intermediate or high‐risk MF who either had an inadequate splenic response or spleen regrowth after ruxolitinib treatment were enrolled. All patients received jaktinib 100 mg Bid. The primary endpoint was the proportion of patients with ≥35% reduction in spleen volume (SVR 35) at week 24. The secondary endpoints included change of MF‐related symptoms, anemic response, and safety profile. From July 6, 2021, to January 24, 2022, 34 ruxolitinib‐refractory or relapsed patients were enrolled, 52.9% (18 of 34) were DIPSS intermediate 2 or high risk. SVR 35 at week 24 was 32.4% (11 of 34, 95% CI 19.1%–49.2%) in all patients and 33.3% (6 of 18, 95% CI 16.3%–56.3%) in the intermediate 2 or high‐risk group. A total of 50% (8 of 16) transfusion‐independent patients with hemoglobin (HGB) <100 g/L at baseline had HGB elevation ≥20 g/L within 24 weeks. Furthermore, 46.4% (13 of 28) of patients had a ≥ 50% decrease in the total symptom score (TSS 50) at week 24. The most common grade ≥3 treatment‐emergent adverse events (TEAEs) were thrombocytopenia (32.4%), anemia (32.4%), and leukocytosis (20.6%). In total, 13 (38.2%) of 34 patients had serious adverse events (SAE), of which drug‐related SAEs were found in 5 patients (14.7%). These results indicate that jaktinib can be a promising treatment option for patients with MF who have either become refractory to or relapsed after ruxolitinib treatment.
Spatially Directed Pyrolysis via Thermally Morphing Surface Adducts
Authors: Du Chuanshen , Gregory Paul , Jamadgni Dhanush U. , Pauls Alana M. , Chang Julia J. , Dorn Rick W. , Martin Andrew , Foster E. Johan , Rossini Aaron J. , Thuo Martin 
Published: July 2023

AbstractCombustion is often difficult to spatially direct or tune associated kinetics—hence a run‐away reaction. Coupling pyrolytic chemical transformation to mass transport and reaction rates (Damköhler number), however, we spatially directed ignition with concomitant switch from combustion to pyrolysis (low oxidant). A ‘surface‐then‐core’ order in ignition, with concomitant change in burning rate,is therefore established. Herein, alkysilanes grafted onto cellulose fibers are pyrolyzed into non‐flammable SiO2 terminating surface ignition propagation, hence stalling flame propagating. Sustaining high temperatures, however, triggers ignition in the bulk of the fibers but under restricted gas flow (oxidant and/or waste) hence significantly low rate of ignition propagation and pyrolysis compared to open flame (Liñán's equation). This leads to inside‐out thermal degradation and, with felicitous choice of conditions, formation of graphitic tubes. Given the temperature dependence, imbibing fibers with an exothermically oxidizing synthon (MnCl2) or a heat sink (KCl) abets or inhibits pyrolysis leading to tuneable wall thickness. We apply this approach to create magnetic, paramagnetic, or oxide containing carbon fibers. Given the surface sensitivity, we illustrate fabrication of nm‐ and μm‐diameter tubes from appropriately sized fibers.
The postcranial anatomy of the saurolophine hadrosaurid Laiyangosaurus youngi from the upper cretaceous of Laiyang, Shandong, China
Authors: Zhang Jialiang , Wang Xiaolin , Jiang Shunxing , Li Guobiao 
Published: July 2023

AbstractLaiyangosaurus youngi was erected as a saurolophine hadrosaurid on the basis of several cranial elements from the Jingangkou Formation, Wangshi Group, Upper Cretaceous of Laiyang, Shandong, China. The postcranial elements of this taxon are described in detail here, providing additional postcranial characteristics to L. youngi. The phylogenetic analysis included postcranial elements of L. youngi, indicating that L. youngi still lies in the Edmontosaurini clade and no more supplement of postcranial autapomorphy. However, three new postcranial autapomorphies can help distinguish L. youngi from other members of Edmontosaurini: a poorly expanded deltopectoral crest of the humerus, a brevis shelf at the base of the postacetabular process of the ilium, and a well‐defined medioventral ridge on the medial side of the postacetabular process. This study is to increase our knowledge on the anatomy and phylogeny of hadrosaurids of Edmontosaurini and provide new valuable evidence for discussing on the taxonomic position and validity of hadrosauroids in the Laiyang Hadrosauroid Fauna.
Biomaterials for in situ cell therapy
Authors: Wang Chang , Wang Siyu , Kang Diana D. , Dong Yizhou 
Published: July 2023

AbstractCell therapy has revolutionized the treatment of various diseases, such as cancers, genetic disorders, and autoimmune diseases. Currently, most cell therapy products rely on ex vivo cell engineering, which requires sophisticated manufacturing processes and poses safety concerns. The implementation of in situ cell therapy holds the potential to overcome the current limitations of cell therapy and provides a broad range of applications and clinical feasibility in the future. A variety of biomaterials have been developed to improve the function and target delivery to specific cell types due to their excellent biocompatibility, tunable properties, and other functionalities, which provide a reliable method to achieve in vivo modulation of cell reprogramming. In this article, we summarize recent advances in biomaterials for in situ cell therapy including T cells, macrophages, dendritic cells, and stem cells reprogramming leveraging lipid nanoparticles, polymers, inorganic materials, and other biomaterials. Finally, we discuss the current challenges and future perspectives of biomaterials for in situ cell therapy.