bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bio-techno-signature Monitoring and Communication Guideposts for Extraterrestrial Life
Authors: Mekel Michele , Keifer-Boyd Karen , Lamb Matthew D. , Stetz Lauren 
Published: March 2023

Abstract
Attendees at the First Penn State SETI Symposium collaborated to develop guideposts for monitoring for and communicating with extraterrestrial life. Over the course of six hours of moderated, dialogic, art-based inquiry in 2022 June, four foundational questions catalyzed the creation of a set of ethics-informed guideposts: Who speaks for Earth, and who should speak for Earth?; What can be communicated, and what is communicated?; What should be communicated?; and How can it be communicated? The 10 resulting parameters offer ethical navigation for examining bio- and techno-markers.
Taxonomic Classification of Asteroids Using the KMTNet Multiband Photometry Data Set
Authors: Choi Sangho , Moon Hong-Kyu , Roh Dong-Goo , Shin Min-Su , Kim Myung-Jin , Sohn Young-Jong 
Published: March 2023

Abstract
We report the multiband photometry of asteroids observed over 14 nights from 2015 December to 2017 December using the Korea Microlensing Telescope Network telescopes with the taxonomic classification of those objects. The data set contains the photometry of 6793 asteroids in the Sloan Digital Sky Survey griz bands. Following the method of DeMeo & Carry, we define classification criteria on the 2D color plane to assign nine taxonomic types (A, B, C, K, L&D, O, S, V, and X) for the observed objects. We also determine asteroid taxonomy in the newly defined 3D color space as suggested by Roh et al. with seven distinct types based on their novel semisupervised machine-learning model. Both methods distinguish between the S type and others but have difficulty separating the X and C types due to their weak and indistinguishable features and broad distribution in the color spaces. The heliocentric distribution of the observed asteroids with their taxonomic assignments confirms similar trends in the previous works; the number of S types decreases, while the fraction of C types increases with the heliocentric distance in the main belt. On the other hand, the D type dominates in the Jupiter Trojans.
The Influence of Cloud Condensation Nucleus Coagulation on the Venus Cloud Structure
Authors: McGouldrick Kevin , Barth Erika L. 
Published: March 2023

Abstract
We present the Venus version of PlanetCARMA and demonstrate the significance of coagulation properties on the structure of the Venus cloud system. The composition of the smallest mode of particles in the Venus atmosphere, which likely serve as cloud condensation nuclei (CCN), is unknown. Here we demonstrate that a change in the ability of CCN to grow via coagulation in the Venus atmosphere can produce measurable short-term and long-term signatures in the Venus cloud structure. Specifically, we find that the existence of a population of CCN that is prevented from growing via coagulation will result in an overall reduced total cloud opacity and can, under some conditions, produce long-term (on the order of several hundred days) variations in both the photochemical cloud opacity (above 57 km) and the condensational cloud opacity (below 57 km). While we show that these variations do not appear to be the source of the short-timescale cloud opacity variations seen on the nightside near-infrared emission of Venus, it is possible that they may contribute to the longer-term variations seen over the 2.5 yr lifetime of the VIRTIS-M-IR instrument on Venus Express. We recommend further modeling studies to investigate wider ramifications of this behavior, as well as further laboratory studies to better constrain the microphysical properties of the aerosols that can make up the Venus clouds.
Mast Cell Proteases Cleave Prion Proteins and a Recombinant Ig against PrP Can Activate Human Mast Cells
Authors: Willows Steven D , Semenchenko Valentyna , Norman Grant , Woodside Michael T , Sim Valerie L , Kulka Marianna 
Published: March 2023

Abstract
IgE Abs, best known for their role in allergic reactions, have only rarely been used in immunotherapies. Nevertheless, they offer a potential alternative to the more commonly used IgGs. The affinity of IgE Ag binding influences the type of response from mast cells, so any immunotherapies using IgEs must balance Ag affinity with desired therapeutic effect. One potential way to harness differential binding affinities of IgE is in protein aggregation diseases, where low-affinity binding of endogenous proteins is preferred, but enhanced binding of clusters of disease-associated aggregated proteins could target responses to the sites of disease. For this reason, we sought to create a low-affinity IgE against the prion protein (PrP), which exists in an endogenous monomeric state but can misfold into aggregated states during the development of prion disease. First, we determined that mast cell proteases tryptase and cathepsin G were capable of degrading PrP. Then we engineered a recombinant IgE Ab directed against PrP from the V region of a PrP-specific IgG and tested its activation of the human mast cell line LAD2. The αPrP IgE bound LAD2 through Fc receptors. Crosslinking receptor-bound αPrP IgE activated SYK and ERK phosphorylation, caused Fc receptor internalization, and resulted in degranulation. This work shows that a recombinant αPrP IgE can activate LAD2 cells to release enzymes that can degrade PrP, suggesting that IgE may be useful in targeting diseases that involve protein aggregation.
CD4 T Cell–Dependent and –Independent Roles for IFN-γ in Blood-Stage Malaria
Authors: Drewry Lisa L , Pewe Lecia L , Hancox Lisa S , Van de Wall Stephanie , Harty John T 
Published: March 2023

Abstract
Production of IFN-γ by CD4 T cells is widely theorized to control Plasmodium parasite burden during blood-stage malaria. Surprisingly, the specific and crucial mechanisms through which this highly pleiotropic cytokine acts to confer protection against malarial disease remain largely untested in vivo. Here we used a CD4 T cell–restricted Cre-Lox IFN-γ excision mouse model to test whether and how CD4 T cell–derived IFN-γ controls blood-stage malaria. Although complete absence of IFN-γ compromised control of the acute and the chronic, recrudescent blood-stage infections with P. c. chabaudi, we identified a specific, albeit modest, role for CD4 T cell–derived IFN-γ in limiting parasite burden only during the chronic stages of P. c. chabaudi malaria. CD4 T cell IFN-γ promoted IgG Ab class switching to the IgG2c isotype during P. c. chabaudi malaria in C57BL/6 mice. Unexpectedly, our data do not support gross defects in phagocytic activity in IFN-γ-deficient hosts infected with blood-stage malaria. Together, our data confirm CD4 T cell–dependent roles for IFN-γ but suggest CD4 T cell–independent roles for IFN-γ in immune responses to blood-stage malaria.
The colored Jones polynomial of the figure-eight knot and a quantum modularity
Authors: Murakami Hitoshi 
Published: March 2023

AbstractWe study the asymptotic behavior of the N-dimensional colored Jones polynomial of the figure-eight knot evaluated at
$\exp \bigl ((u+2p\pi \sqrt {-1})/N\bigr )$
, where u is a small real number and p is a positive integer. We show that it is asymptotically equivalent to the product of the p-dimensional colored Jones polynomial evaluated at
$\exp \bigl (4N\pi ^2/(u+2p\pi \sqrt {-1})\bigr )$
and a term that grows exponentially with growth rate determined by the Chern–Simons invariant. This indicates a quantum modularity of the colored Jones polynomial.
Reporting of Azithromycin Activity against Clinical Isolates of Extensively Drug-Resistant Salmonella enterica Serovar Typhi
Authors: Jabeen Kokab , Saleem Sidrah , Nizamuddin Summiya , Arshad Faiqa , Jahan Shah , Hasnain Faisal , Tariq Waleed , Tahir Muhammad Junaid , Yousaf Zohaib , Asghar Muhammad Sohaib 
Published: March 2023

ABSTRACT.
This study aimed to evaluate the minimum inhibitory concentration (MIC) of azithromycin (AZM) in clinical isolates of extensively drug-resistant (XDR) Salmonella Typhi (i.e., resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, fluoroquinolones, and third-generation cephalosporin) using the E-test versus the broth microdilution method (BMD). From January to June 2021, a retrospective cross-sectional study was carried out in Lahore, Pakistan. Antimicrobial susceptibility was performed initially by the Kirby-Bauer disk diffusion method for 150 XDR Salmonella enterica serovar Typhi isolates, and MICs of all the recommended antibiotics were determined by the VITEK 2 (BioMérieux) fully automated system using Clinical Laboratory Standard Institute (CLSI) 2021 guidelines. The E-test method was used to determine AZM MICs. These MICs were compared with the BMD, which is the method recommended by the CLSI but not adopted in routine laboratory reporting. Of 150 isolates, 10 (6.6%) were resistant by disk diffusion. Eight (5.3%) of these had high MICs against AZM by the E-test. Only three isolates (2%) were resistant by E-test, having an MIC of 32 μg/mL. All eight isolates had a high MIC by BMD with different MIC distributions, but only one was resistant, having an MIC of 32 μg/mL by BMD. The sensitivity, specificity, negative predictive value, positive predictive value, and diagnostic accuracy of the E-test method versus BMD were 98.65%,100%, 99.3%, 33.3%, and 98.6%, respectively. Similarly, the concordance rate was 98.6%, negative percent agreement was 100%, and positive percent agreement was 33%. The BMD is the most reliable approach for reporting AZM sensitivity in XDR S. Typhi compared with the E-test and disk diffusion methods. Potentially, AZM resistance in XDR S. Typhi is around the corner. Sensitivity patterns should be reported with MIC values, and if possible, higher values should be screened for the presence of any potential resistance genes. Antibiotic stewardship should be strictly implemented.
The Development and Evaluation of a Combined Infection–Rheumatology Assessment Service in Response to the Chikungunya Fever Epidemic
Authors: Krutikov Maria , Donovan Joseph , Lambourne Jonathan , Ciurtin Coziana , Brown Mike , Bailey Robin , Manson Jessica J. 
Published: March 2023

ABSTRACT.
The chikungunya virus is an arthritogenic alphavirus. Acute infection may be followed by persistent arthralgia, often causing significant functional impairment. The 2014–2015 chikungunya fever (CHIKF) epidemic resulted in a marked increase in cases presenting to rheumatology and tropical diseases services. A combined multidisciplinary rheumatology–tropical diseases service for assessment, management, and follow-up of patients with proven CHIKF and persistent (≥ 4 weeks) arthralgia was proposed and rapidly developed at The Hospital for Tropical Diseases in London. Rapid set up of a multidisciplinary clinic in response to the epidemic was achieved. Of a total of 54 patients, 21 (38.9%) patients with CHIKF developed persistent arthralgia and were reviewed by the multidisciplinary service. A combined assessment approach enabled comprehensive multidisciplinary assessment of CHIKF, assessment of joint pathology through ultrasound, and appropriate follow-up. A combined rheumatology–tropical diseases service was successfully used to identify and assess CHIKF-associated morbidity. Future outbreaks may be approached by establishing tailored multidisciplinary clinics.
Use of Herbal Drugs in Local Health Traditions in Purnagiri Hills, District Champavat, Uttarakhand
Authors: Nitin Kumar  , Mishra H.S  , Agarwal A  , Kumar Kaushal  , Bedar SS  
Published: March 2023

The state Uttarakhand is rich with floral and faunal diversity including plants used by local inhabitance to cure health problems. Himalayan region always has been the treasure of herbs from ancient time. Himalayan herbs are highest in quality and potency. There are numbers of side effect are noted using allopathic medicines which leads towards reuse of medicinal plants available locally. Keeping this in view an attempt has been made to enumerate the common medicinal plants used in traditional therapeutic system of Uttarakhand, India. Results reveal that 29 plant species are used for primary healthcare.
Purnagiri hills located in Champavat district of Uttarakhand is reservoir for a large number of medicinal herbs during the field survey large number of medicinal plants like Adina cordifolia (Roxb.) Hook. (Rubiaceae), Asparagus adscendence Roxb. (Liliaceae), Artemesia nilgirica (Clarke) Pamp. (Asteraceae), Berberis aristata DC. (Berberiridaceae), Colebrookea oppositefolia Sm. (Lamiaceae), Elephantopus scaber L (Asreraceae), Pinus longifolia Roxb. (Pinaceae), Tamarix gallica L. (Tamaraceae), Urtica dioica L. (Urtecaceae) and many more with their use in local health traditions by local habitants were recorded. One of the serious challenges to biodiversity and ecological functioning is climate change. Climate change and global warming are well known issue that has had an impact on the biodiversity. Second thing over exploitation of Himalayan forest leads these valuable herbs in endangered category. Some of the plants recorded are critically endangered and rare. We have to pay attention towards the conservation, cultivation of these herbs.
Kerala Traditional Ayurvedic Practices in Children for Enhancing Immunity - A Systematic Review
Authors: Veena L  , Anu M S  , Delvin T Robin  , Anusree Dileep  
Published: March 2023

Kerala is rich in its culture for the traditional Ayurveda practices in children from the time of birth onwards. These traditional practices are mainly immune boosters and also enhance overall nourishment and development in children. Commonly used traditional Ayurveda practices are Uramarunnu Prayoga, Prakara Yoga, Abhyanga, Rasanadi churna lepana, Snana etc. for enhancing immunity and providing overall development to children. Uramarunnu is a baby care practice comprising of a group of drugs administered to the child in the form of paste in breast milk, after 28 days till 2 years of age. Prakara Yogas are immunomodulatory recipes and procedures to be adopted right from the day after delivery. Abhyanga provides nourishment, health, protection, emotional well-being and improves skin tone. All these can be used for enhancing immunity and preventing recurrent infections thereby helps in the maintenance of health and prevention of diseases. This mentions the importance of Kerala traditional Ayurvedic practices in the field of primary child health care. So, the present study aims to compile Kerala’s traditional Ayurvedic practices in children, by reviewing regional textbooks like Arogyakalpadruma, Vaidya Tarakam, Parambarya Balachikitsa etc., and also interviewing Ayurveda pediatrician through telephone.
Análisis y propuesta para el reconocimiento de los derechos de la naturaleza
Authors: Huanca Excelmes Irene Yuvalena 
Published: March 2023

Leer noticias en las que se reconocen derechos a los ríos como el “Atrato” en Colombia, el río “Ganges y Yamuma” en India, el río “Yarra” en Australia el río “Te Urewera” en Nueva Zelandia, o el reconocimiento de la amazonía colombiana como sujeto de derechos y en el ámbito nacional tenemos el proyecto de ley N°06957/2020-CR, a través del cual se pretende “reconocer que la madre naturaleza, los ecosistemas y las especies son titulares de derechos y sujetos de protección por parte del Estado, por tratarse de entes vivos, con valor intrínseco y universal, que tienen derecho a existir, desarrollarse naturalmente, regenerarse, restaurarse y evolucionar” y a nivel local tenemos la ordenanza Municipal N° 018-2019-CM-MPM/A del 23 de setiembre del 2019 Reconoce a “la cuenca del río Llallimayo como sujeto de derecho con el fin de institucionalizar y generar los mecanismos y estrategias municipales que garanticen la conservación y gestión sostenible en beneficio de la población y de los ecosistemas” y la Ordenanza Distrital N° 006-2019-MDO/A del 26 de diciembre de 2019 en cuyo Artículo 1° reconocer a la madre agua-Yaku-Unu Mama como un ser viviente sujeto de derechos en todas sus formas: puquios, manantiales, ríos, lagunas, lagos. Nos provoca la siguiente pregunta: ¿es el momento histórico para incorporar constitucionalmente derechos a la naturaleza? ¿Es el momento histórico para incorporar principios que cimienten un biocentrismo? Es pues una tarea pendiente que debe ser debatida nuevamente en nuestro futuro próximo.
A ESCOLA E A EDUCAÇÃO DEMOCRÁTICAS: UMA QUESTÃO PENDENTE NO CONTEXTO MOÇAMBICANO E UM DESAFIO ATUAL
Authors: Mechiço Rosa Alfredo 
Published: March 2023

Relativamente à eventualidade da escola e a educação democráticas serem tomadas como uma questão pendente no contexto Moçambicano e um desafio actual interessa, antes de tudo, ressaltar que para a percepção do estágio actual da educação e escola moçambicanas, sobretudo a pretensão de edificarem-se e consolidarem-se como democráticas, é essencial levar em linha de conta que a escola e a educação democráticas constituem alguns dos instrumentos de consecução de uma sociedade democrática, a medida que universalizam o saber sistematizado e, igualmente, permitem a convivência democrática através da vivência de experiências democráticas, essenciais para o exercício da democracia. Concomitantemente, a medida que a democracia capitaliza experiências democráticas no processo educacional, a agência escolar se torna um vector real da democracia. Dado que a consolidação da democracia e da cidadania democrática passa, inevitavelmente, por uma educação-formação democrática, o grande desafio para o Estado moçambicano prende-se com o facto de tomar como prioridade e urgente a necessidade de investir-se na escola como agência de formação democrática, isto é, tomá-la na qualidade de factor gerador de competências e habilidades democráticas, tais como o diálogo, a liberdade de expressão, a participação, a tolerância, a solidariedade, a cooperação, o respeito pelas diferenças, etc.
APRESENTAÇÃO - DOSSIÊ: OS PRINCÍPIOS TRANSVERSAIS DO ENSINO, PESQUISA E EXTENSÃO (BRASIL/MOÇAMBIQUE)
Authors: Barros Eduardo Portanova , Rocha Gabriel Kafure da , Rocha Roselandia Coelho , Mechiço Rosa Alfredo 
Published: March 2023

Quando pensamos na chamada OS PRINCÍPIOS TRANSVERSAIS DO ENSINO, PESQUISA E EXTENSÃO (BRASIL/MOÇAMBIQUE) que foi tão bem acolhida por diferentes pesquisadores do mundo, não sabíamos o que viríamos a receber. Agora, com nosso dossiê bem desenhado, temos a certeza de que realmente Paulo Freire transcende as comunicações e extensões possíveis, por isso a pluralidade que veremos nesse dossiê é de que a educação transforma o mundo.
Nihonggo No Benkyou: The Case of Filipino ESL Teachers in Graduate School
Authors: Lumabi Bethany Marie 
Published: March 2023

In 2010, the Commission on Higher Education (CHED) institutionalized the offering of foreign languages in the curricular programs of higher education institutions to accord global acceptance of local graduates in the Philippines. In graduate school, Nihongo is one of the foreign languages commonly offered in the local university. Theoretically, the second language acquisition of adult learners (i.e., graduate students) is crucial and different from adolescent language learners. And there is a dearth of literature on Filipinos learning Nihongo; most of them involve college students and overseas Filipino workers (OFWs) and less among ESL teachers in graduate school. This study: (1) contributed to the limited evidence in Japanese language learning of Filipino students; showed qualitative evidence on the CPH of adult learning a third or fourth language. Results revealed that though most of the ESL teachers in graduate school were middle-aged, they partly considered their age crucial in learning Nihongo and declared that their age was not the only factor in recognizing their difficulties in learning a foreign language rather other learning limitations such as affective factors, learning environment, workload, etc.; (2) presented the ESL teachers’ difficulties in learning Nihongo language in the graduate school such as writing and translating sentences and phrases, vocabulary and pronunciation; and (3) showed their strategies in learning the Japanese language as an academic requirement were creating mental linkages, applying images and sounds, reviewing well, and employing actions. Thus, this study presented recommendations for the effective teaching of Japanese language among graduate students in the Philippines.
vigencia de las representaciones de masculinidad en el cine mexicano de 1940 a 1980 en las telenovelas de Televisa (1958-2018), desde la perspectiva de género de Raewyn Connell y Simone de Beauvoir
Authors: Guzmán Nathaly 
Published: March 2023

No hay resúmenes disponibles.
Investigaciones UCA, Año. 1, Vol. 1, 2019-2020: 360-363.
Propuesta de implementación de RCM en sistema de separación y reinyección de agua en una central geotérmica de El Salvador
Authors: Figueroa Cobar Óscar Rafael , Flores Soto José Alberto , Vargas Miranda Jaime Miguel 
Published: March 2023

No hay resúmenes disponibles.
Investigaciones UCA, Año. 1, Vol. 1, 2019-2020: 380-383.
Revisión crítica de la idea de progreso. Bases para una reforma teórica, epistemológica y metodológica de las ciencias sociales en El Salvador
Authors: Samour Héctor Jesús , Monterrosa Luis Antonio , García Sandra Marielos , Martínez Evelin Patricia , Flores Dulcinea Ruthdey , Cummings Andrew 
Published: March 2023

No hay resúmenes disponibles.

Investigaciones UCA, Año. 1, Vol. 1, 2019-2020: 152-156.
Situación de la empresa salvadoreña frente a la emergencia COVID-19
Authors: Guevara Jaime , Tovar Diego , Pacheco Ernesto , Cartagena Haydee , Palacios Santiago 
Published: March 2023

No hay resúmenes disponibles.

Investigaciones UCA, Año. 1, Vol. 1, 2019-2020: 202-207.
EFISIENSI PERPINDAHAN PANAS PADA ALAT PENUKAR KALOR TIPE CANGKANG DAN PIPA PT PETROKIMIA GRESIK
Authors: Sekarningrum Salma , Amalia Kusuma Putri Rizka , Sani Sani 
Published: March 2023

Alat penukar kalor adalah alat yang digunakan untuk memindahkan panas dari sistem ke sistem lain tanpa perpindahan massa dan bisa berfungsi sebagai pemanas maupun sebagai pendingin. Biasanya, medium pemanas yang dipakai adalah air yang dipanaskan sebagai fluida panas dan air biasa sebagai air pendingin (cooling water). Petrokimia Gresik memiliki alat penukar kalor tipe cangkang dan pipa (shell and tube) yang berfungsi sebagai pendingin pada proses absorpsi. Alat penukar kalor berfungsi untuk mengatur temperatur H2SO4 yang akan masuk ke absorber. Oleh karena itu, alat penukar kalor E-1303 dituntut untuk memiliki kinerja yang baik agar produk berupa H2SO4 diperoleh secara maksimal. Data yang digunakan berupa data desain dan data aktual dimana diperoleh tekanan turun pada cangkang (ΔPS) sebesar 9,5403 psi dan tekanan rendah pada pipa (ΔPT) sebesar 9,3537 psi untuk data desain serta nilai tekanan rendah data aktual pada shell (ΔPS) sebesar 9,4606 psi dan tekanan rendah pada pipa (ΔPT) sebesar 7,5972 psi. Hasil tersebut menunjukkan tekanan rendah yang didapat dibawah nilai penurunan tekanan. Oleh karena itu, dapat disimpulkan bahwa kinerja alat penukar kalor E-1303 berdasarkan data desain dapat dikatakan dalam kinerja yang baik dinilai dari aspek faktor pengotor (Rd) dan tekanan rendah.