bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration in und durch den organisierten Sport: Kommunikations- und netzwerktheoretische Überlegungen
Authors: Cachay Klaus , Borggrefe Carmen , Hoffmann Andreas 
Published: April 2023

Zusammenfassung
Der Beitrag entwickelt einen theoretischen Ansatz zur Analyse von Integrationsprozessen im Kontext des organisierten Sports. Dabei wird erstens entlang kommunikationstheoretischer Überlegungen reflektiert, wie sich in innerhalb der Kommunikation zwischen Sportgruppenmitgliedern mit und ohne Migrationshintergrund eine Integration in den Sport fördern lässt. Entlang netzwerktheoretischer Überlegungen wird zweitens reflektiert, wie über soziale Netzwerke die Integration von Personen mit Migrationshintergrund durch Sport in die Gesellschaft gefördert werden kann.
Effects of Cannabidiol, Hypothermia, and Their Combination in Newborn Rats with Hypoxic-Ischemic Encephalopathy
Authors: Alvarez Francisco J. , Alvarez Antonia A. , Rodríguez José. J. , Lafuente Hector , Canduela M. Josune , Hind William , Blanco-Bruned José L. , Alonso-Alconada Daniel , Hilario Enrique 
Published: April 2023

AbstractTherapeutic hypothermia is well established as a standard treatment for infants with hypoxic-ischemic (HI) encephalopathy but it is only partially effective. The potential for combination treatments to augment hypothermic neuroprotection has major relevance. Our aim was to assess the effects of treating newborn rats following HI injury with cannabidiol (CBD) at 0.1 or 1 mg/kg, i.p., in normothermic (37.5°C) and hypothermic (32.0°C) conditions, from 7 d of age (neonatal phase) to 37 d of age (juvenile phase). Placebo or CBD was administered at 0.5, 24, and 48 h after HI injury. Two sensorimotor (rotarod and cylinder rearing) and two cognitive (novel object recognition and T-maze) tests were conducted 30 d after HI. The extent of brain damage was determined by magnetic resonance imaging, histologic evaluation, magnetic resonance spectroscopy, amplitude-integrated electroencephalography, and Western blotting. At 37 d, the HI insult produced impairments in all neurobehavioral scores (cognitive and sensorimotor tests), brain activity (electroencephalography), neuropathological score (temporoparietal cortexes and CA1 layer of hippocampus), lesion volume, magnetic resonance biomarkers of brain injury (metabolic dysfunction, excitotoxicity, neural damage, and mitochondrial impairment), oxidative stress, and inflammation (TNFα). We observed that CBD or hypothermia (to a lesser extent than CBD) alone improved cognitive and motor functions, as well as brain activity. When used together, CBD and hypothermia ameliorated brain excitotoxicity, oxidative stress, and inflammation, reduced brain infarct volume, lessened the extent of histologic damage, and demonstrated additivity in some parameters. Thus, coadministration of CBD and hypothermia could complement each other in their specific mechanisms to provide neuroprotection.
Effect of Reverberation on Neural Responses to Natural Speech in Rabbit Auditory Midbrain: No Evidence for a Neural Dereverberation Mechanism
Authors: Barzelay Oded , David Stephen , Delgutte Bertrand 
Published: April 2023

AbstractReverberation is ubiquitous in everyday acoustic environments. It degrades both binaural cues and the envelope modulations of sounds and thus can impair speech perception. Still, both humans and animals can accurately perceive reverberant stimuli in most everyday settings. Previous neurophysiological and perceptual studies have suggested the existence of neural mechanisms that partially compensate for the effects of reverberation. However, these studies were limited by their use of either highly simplified stimuli or rudimentary reverberation simulations. To further characterize how reverberant stimuli are processed by the auditory system, we recorded single-unit (SU) and multiunit (MU) activity from the inferior colliculus (IC) of unanesthetized rabbits in response to natural speech utterances presented with no reverberation (“dry”) and in various degrees of simulated reverberation (direct-to-reverberant energy ratios (DRRs) ranging from 9.4 to –8.2 dB). Linear stimulus reconstruction techniques (Mesgarani et al., 2009) were used to quantify the amount of speech information available in the responses of neural ensembles. We found that high-quality spectrogram reconstructions could be obtained for dry speech and in moderate reverberation from ensembles of 25 units. However, spectrogram reconstruction quality deteriorated in severe reverberation for both MUs and SUs such that the neural degradation paralleled the degradation in the stimulus spectrogram. Furthermore, spectrograms reconstructed from responses to reverberant stimuli resembled spectrograms of reverberant speech better than spectrograms of dry speech. Overall, the results provide no evidence for a dereverberation mechanism in neural responses from the rabbit IC when studied with linear reconstruction techniques.
Syngap1Disruption Induced by Recombination between Inverted loxP Sites Is Associated with Hippocampal Interneuron Dysfunction
Authors: Khlaifia Abdessattar , Jadhav Vidya , Danik Marc , Badra Théo , Berryer Martin H. , Dionne-Laporte Alexandre , Chattopadhyaya Bidisha , Di Cristo Graziella , Lacaille Jean-Claude , Michaud Jacques L. 
Published: April 2023

AbstractSYNGAP1haploinsufficiency in humans causes intellectual disability (ID). SYNGAP1 is highly expressed in cortical excitatory neurons and, reducing its expression in mice accelerates the maturation of excitatory synapses during sensitive developmental periods, restricts the critical period window for plasticity, and impairs cognition. However, its specific role in interneurons remains largely undetermined. In this study, we investigated the effects of conditionalSyngap1disruption in medial ganglionic eminence (MGE)-derived interneurons on hippocampal interneuron firing properties and excitatory synaptic inputs, as well as on pyramidal cell synaptic inhibition and synaptic integration. We show that conditionalSyngap1disruption in MGE-derived interneurons results in cell-specific impairment of firing properties of hippocampal Nkx2.1 fast-spiking interneurons, with enhancement of their AMPA receptor (AMPAR)-mediated excitatory synaptic inputs but compromised short-term plasticity. In contrast, regular-spiking Nkx2.1 interneurons are largely unaffected. These changes are associated with impaired pyramidal cell synaptic inhibition and enhanced summation of excitatory responses. Unexpectedly, we found that theSyngap1floxallele used in this study contains inverted loxP sites and that its targeted recombination in MGE-derived interneurons induces some cell loss during embryonic development and the reversible inversion of the sequence flanked by the loxP sites in postmitotic cells. Together, these results suggest thatSyngap1plays a role in cell-specific regulation of hippocampal interneuron function and inhibition of pyramidal cells in mice. However, because of our finding that theSyngap1floxallele used in this study contains inverted loxP sites, it will be important to further investigate interneuron function using a differentSyngap1conditional allele.
Local Wisdom: The Study of Takjil Selling Phenomenon in Jakarta 2017--2019
Authors: Misbah M. Ma'ruf 
Published: April 2023

PurposeThe article aims to identify the phenomenon of Takjil selling which is rife in the month of Ramadan in Jakarta, which was carried out in 2017--2019 before the Covid-19 pandemic. MethodThis research used qualitative and descriptive research methods with a cultural anthropology approach. Various online information in the form of coverage of takjil selling in various places in Jakarta in 2017--2019 is used as primary sources. Results/FindingThe results found that there is local wisdom in the phenomenon of takjil selling. The takjil sellers are able to respond local conditions in the local environment around the takjil selling center by serving several Betawi typical foods in their menu. By selling Betawi typical foods and other numerous kinds of food that fitted to the consumers tastes, they can gain profit, help the consumers providing food for breaking their fast and preserve Betawi food. ConclusionThe research concluded that the phenomenon of takjil selling in the month of Ramadhan in Jakarta in 2017-2019 was not only revealed that there is a local wisdom in the activity of selling takjil but it is also a media to increase economic, strengthen solidarity among muslim and reinforce Betawi civilization.
Daffodils and Solitude in William Wordsworth’s I Wandered Lonely as A Cloud
Authors: Suwastini Ni Komang Arie , Pradnyani Pande Eka Putri 
Published: April 2023

PurposeThis study aims to identify the meaning of Wordsworth’s poem entitled I Wandered Lonely as a Cloud by analyzing its intrinsic elements. MethodThe present study is qualitative interpretive, focusing on the meaning conveyed in the poem entitled I Wandered Lonely as a Cloud using objective approach by interpreting the poem’s intrinsic elements through repeated reading of the poem as a whole and its details to achieve trustworthy analysis and conclusion. Results/findingsDifferent from general trend in the analysis Wordsworth’s I Wandered Lonely as a Cloud, the meaning of the poem is the experience of recalling the sight of the daffodils, which brought solitude to the speaker of the poem. The poem’s subject was not the daffodils, but the experience of encountering them and its recollection. As a traveler traveling in the countryside, the speaker viewed the sight of the daffodils in a positive tone through imageries of sight, internal sensation, and muscle movements related to good experiences, as well as dictions of natural views with positive connotations. The poem includes simile, personification, metonymy, and symbols to compare the beautiful crowd of daffodils and the solitude they bring to the speaker of the poem’s mind when he was recalling the sight of the dancing daffodils. ConclusionUsing Abram’s objective point of view, the analysis reveals the daffodils as representative of nature become the remedy for human’s loneliness as represented by the speaker of the poem by recalling the experience of seeing them, sending the message that appreciation of nature and the experience with nature should be maintained to create a tranquil life.
The Red River Cart Model: a Métis conceptualization of health and well-being in the context of HIV and other STBBI
Authors: Atkinson Danielle , Landy Rachel , St. Denys Raye , Ogilvie Kandace , Lund Carrielynn , Worthington Catherine ,   the DRUM & SASH team
Published: April 2023

Abstract
Objectives
Métis people experience health inequities and often face discrimination when accessing health services. Métis-specific services are limited, and pan-Indigenous approaches to health services fail to acknowledge heterogenous identities and distinct health needs of the Métis. This study explored a Métis response to HIV and other sexually transmitted and blood borne infections to inform public health services development for Métis people.

Methods
As part of the DRUM & SASH Project, this study used a community-based research approach which privileged Métis knowledges and processes. Three gathering circles were held in Alberta, Canada, with self-identified Métis individuals who had lived experience or intimate knowledge of HIV/hepatitis C or worked in HIV/HCV service provision. The gathering circle process integrated Métis cultural practices in discussions about Métis understandings of health. Gathering circles transcripts were used to inform the description of the model emerging through the dialogue.

Results
Twelve diverse Métis people participated in gathering circles. Participants identified 12 determinants of health and well-being grounded in Métis culture and imagery, including Métis medicine bag, fiddle, cart tarp, flag, Capote coat, sash, York boat, moccasins, grub box, weapons, tools, and stove. The Red River Cart Model, a Métis-specific model of health to guide service planning, was created from these discussions.

Conclusion
The Red River Cart Model provides a holistic view of the determinants of Métis health and has potential as a collaborative client assessment resource for STBBI community health service providers. Additionally, this model may be helpful to other health service providers for developing Métis-specific/informed services and improving cultural safety for the Métis.
Gota en el anciano
Authors: Agudelo Carlos Andrés , Uribe Oscar 
Published: April 2023

Los libros de texto y la literatura reumatológica en general, hacen hincapié en la presentación clínica clásica del paciente con gota y en su tratamiento médico. Con frecuencia, sin embargo, la presentación no es típica en el anciano y el diagnóstico pasa desapercibido o se establece en forma errónea.En las mujeres mayores de 60 años la presentación de la gota puede ser pollarticular, de Iniciación lenta, no aguda, y con compromiso de articulaciones pequeñas de las manos, dando lugar a confusión con una posible artritis reumatoidea o con la exacerbación de un proceso degenerativo. El examen cuidadoso del líquido sinovial y la identificación de los cristales de urato monosódico son primordiales para el diagnóstico. Es preciso conocer las interacciones farmacodinámicas de las medicaciones antinflamatorias e hipouricemlantes con otras que el paciente pueda estar tomando para procesos asociados. El médico debe abstenerse de tratar la hiperuricemia asintomática. Una vez confirmado el diagnóstico de gota debe trazarse un plan de tratamiento y seguimiento. Las reacciones severas a los antinflamatorios no esteroideos, a la colchicina y al alopurinol son más frecuentes en el anciano.
Intoxicación plúmbica por heridad de bala en una articulación. Presentación de un caso y revisión del tema
Authors: Botero Carlos A. , Villa Alvaro , Benavides Carlos 
Published: April 2023

Se presenta el caso de un paciente de 32 años con antecedente de herida por bala en la articulación coxofemoral derecha, 6 años antes, sin exposición laboral al plomo, quien presentó un cuadro clásico de saturnismo y niveles de plumbemia de 99 µg/dl; después de la extracción de la bala hubo mejoría clínica y de laboratorio, incluyendo disminución de dichos niveles. Se revisa y discute la escasa literatura existente al respecto haciendo énfasis en la importancia de un seguimiento periódico, con determinaciones de plomo en sangre a todo paciente con heridas por bala cuando el proyectil queda retenido en una articulación.
Riesgos asociados al uso de pantallas de computador y recomendaciones para controlarlos
Authors: Gómez Cadavid Alfredo 
Published: April 2023

El uso generalizado de las llamadas nuevas tecnologías, entre ellas las pantallas de computador (Video Display Unit, VDU) trae consigo muchos beneficios pero puede alterar la salud de los usuarios. El alto número de pantallas, su Introducción temprana en el proceso educativo y el gran número de quejas de los usuarios, ha conducido a que este sea el problema de salud ocupacional más ampliamente investigado durante los últimos años. Las quejas de los usuarios son de tres tipos: A. Sobre el diseño del puesto de trabajo, incluyendo equipos, factores ambientales y aspectos ergonómicos. B. Relativas al estrés producido por trabajar ante una pantalla. C. Referentes a alteraciones en el estado de salud tales como problemas visuales, trastornos músculo-esqueléticos, cefaleas, salpullido y riesgos para el embarazo. En este artículo se consideran además los siguientes puntos:1. Aspectos técnicos y de salud ocupacional de las pantallas.2. Efectos sicosociales del trabajo con pantallas.3. Efectos sobre la salud de los usuarios. Se concluye que el uso de pantallas no es peligroso para la salud cuando las condiciones ambientales, ergonómicas y organizativas son adecuadas y el estado de salud del usuario es apropiado para este trabajo.
El paciente terminal: Lectio inaugural del I encuentro interdisciplinario sobre la fase terminal y la muerte
Authors: Vélez Atehortua Hernán 
Published: April 2023

En el marco de la celebración de los 190 años de la Universidad de Antioquia han querido los directivos universitarios y la Fundación "Cátedra Fernando Zambrano Ulloa" dedicar un espacio a la discusión de un nuevo tema que ha aparecido en la modernidad: El Paciente Terminal que no es otra cosa que el hombre que muere en medio de un gran componente científico.
La relación médico-paciente
Authors: Bedoya Restrepo Jaime 
Published: April 2023

Llama la atención el inusitado interés que en los últimos tiempos ha despertado el aspecto ético del ejercicio de la medicina. Este interés, no obstante, parece más centrado en los aspectos legales y sólo tangencialmente en el dilema moral que se origina en muchas de las actuaciones de los médicos. La relación médico-paciente se puede entender como de tipo contractual, fundamentada en la confianzay el respeto mutuos, condicionada por la necesidad de ayuda por parte del enfermo y suministrada ésta por un profesional competente.
Aspectos de la irrupción del pasterianismo en Antioquia
Authors: Márquez Valderrama Jorge 
Published: April 2023

La medicina antioqueña del siglo XIX surgió como una propuesta oficial, en un esquema de medicina urbana y basada en el modelo francés de los siglos XVIII y XIX. Este esquema impulsaba la intervención médica autoritaria en casi todos los dominios del ordenamiento urbano. A finales del siglo pasado aparecieron en Medellín las políticas sanitarias medicalizadoras administradas por una institución oficial centralista en la cual los médicos jugaron un papel muy importante como funcionarios. Varios médicos muy destacados, formados en Francia o inspirados en la medicina gala (pasterianos y prepasterianos), impulsaron en esta ciudad un tipo de higiene basado en la mezcla de varias teorías que explicaban la causa de las enfermedades epidémicas y endémicas. La época dorada de este movimiento la constituyó el último decenio del siglo, cuando se aceptaron plenamente en Medellín las teorías de Louis Pasteur. Así, la naciente Bacteriología tuvo un papel protagónico no sólo en el ejercicio médico sino en el ordenamiento urbano de la ciudad.
Concept analysis of depression in women
Authors: Armendáriz García Nora Angélica , Alonso Castillo María Magdalena , López García Karla Selene , Alonso Castillo Bertha Alicia 
Published: April 2023

Objective. To identify the elements characterizing the concept of depression in women through the revision of the definitions and uses of the concept in literature, as well as identify its attributes, antecedents, and consequential events.
Methodology. Some steps were used from the methodology of the concept's analysis by Walker and Avant.
Results. Through the analysis performed, we managed to identify that depression is a complex concept associated to other similar concepts (sadness, melancholy, among others); however, upon elaborating the present analysis it was considered that the main attribute of depression in women was the presence of inhibition or delay of motor functions, as well as the presence of altered frame of mind. Likewise, hormonal alteration was identified as the principal antecedent for its presence. The consequence identified most frequently was that of suicidal thoughts.
Conclusion. The study managed to introduce primordial aspects of the concept of depression in women. The use of this concept must be adapted and applied in the daily nursing practice.
Genetic profile of patients with stage I–IIIA non-small cell lung cancer
Authors: Kazakov A. M. , Laktionov K. K. , Sarantseva K. A. 
Published: April 2023

Background. The article presents data on somatic mutations found in the Russian population of patients with non-small cell lung cancer (NSCLC), their frequency, distribution depending on the histological type of tumor.Aim. To study the molecular genetic profile of Russian patients with stage I–IIIA localized NSCLC, the frequency of occurrence of various somatic mutations, variants of the switching status.Materials and methods. Genetic testing for a panel of 78 genes using the Next Generation Sequencing method of tumor material obtained after surgical treatment of 65 patients with localized stage I–IIIA NSCLC. Processing of the received data was carried out by methods of descriptive statistics.43Results. Mutations in the EGFR, ALK, ROS1, RET, BRAF, KRAS, MET, HER2 genes were found only in adenocarcinoma. Among non-targeted mutations in adenocarcinoma, TP53, STK11, FGFR3, EML4, NF1, RB1, and KMTC2 mutations were the most common. In squamous cell lung cancer, TP53, KMT2C, TSC1, EML4, PTEN, NF1, COL22A1, CDKN2A, RB1, BRCA1 were the most common. Mutations in the EGFR gene were most often associated with mutations in TP53 (30 % of cases), RB1 (15 % of cases), COL22A1 (15 % of cases); ALK was combined with TP53, NF1, WT1 – in 33 % of cases, ROS1 with DDR2 (33 % of cases), ERBB2 was combined with NTRK1, GPC3, HIP1, KIF5B, TP53, XPC, COL22A1 – in 14 % of cases, BRAF was most often associated with mutations in the TP53 gene (14 %) and COL22A1 (13.8 %); a mutation in the RET gene was associated with a TP53 mutation; ROS1 translocation in 50 % of cases was associated with mutations in the TRIM33 and TP53 genes.Conclusion. The data obtained give an idea of the frequency of occurrence of somatic mutations among Russian patients with NSCLC, which is important for the selection of diagnostic panels, interpretation of their results, and also potentially for the development of original custom Next Generation Sequencing testing panels.
On the Importance of Using Directional Information in the Search for Lower Mantle Reflectors
Authors: Rochira Federica , Thomas Christine 
Published: April 2023

Abstract
The SS precursor signals are a powerful tool for mapping topography of mantle discontinuities, which are sensitive to the thermal and compositional structure of the mantle. The depth of mantle discontinuities is usually estimated using the differential travel time between the main arrival and its precursor. However, this method ignores potential travel path deviations that influence the travel time of precursor signals. Here, we use an approach that considers directivity information as well as travel-time measurements. Applying seismic array techniques, we measure slowness, back azimuth, and travel time of the signals, and use this information to backproject to the point of reflection. In our test dataset, we observe deviations from the predicted values in slowness and back azimuth in the range of 0.1–2.3 s/° and 1–20°, respectively. These values lead to reflection locations that can differ considerably from theoretical reflection points calculated with great circle plane paths as well as depths different from the depth calculated for in-plane propagation, with differences up to ∼150 km. Our results indicate that the travel-path deviations should be considered to avoid misinterpretation of mantle discontinuities and potentially reduce previously observed scatter in discontinuity depth.