bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy, safety, and biomarker analysis of nivolumab in combination with abemaciclib plus endocrine therapy in patients with HR-positive HER2-negative metastatic breast cancer: a phase II study (WJOG11418B NEWFLAME trial)
Authors: Masuda Jun , Sakai Hitomi , Tsurutani Junji , Tanabe Yuko , Masuda Norikazu , Iwasa Tsutomu , Takahashi Masato , Futamura Manabu , Matsumoto Koji , Aogi Kenjiro , Iwata Hiroji , Hosonaga Mari , Mukohara Toru , Yoshimura Kiyoshi , Imamura Chiyo K , Miura Sakiko , Yamochi Toshiko , Kawabata Hidetaka , Yasojima Hiroyuki , Tomioka Nobumoto , Yoshimura Kenichi , Takano Toshimi 
Published: September 2023

BackgroundHormone receptor (HR)-positive breast cancer is a disease for which no immune checkpoint inhibitors have shown promise as effective therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors synergistically increased the effectiveness of antiprogrammed cell death protein-1 (anti-PD-1)/programmed death-ligand 1 (PD-L1) antibodies in preclinical studies.MethodsThis non-randomized, multicohort, phase II study evaluated the efficacy and safety of the anti-PD-1 antibody nivolumab 240 mg administered every 2 weeks in combination with the CDK4/6 inhibitor abemaciclib 150 mg twice daily and either fulvestrant (FUL) or letrozole (LET) as a first-line or second-line treatment for HR-positive HER2-negative metastatic breast cancer. The primary end point was the objective response rate (ORR), and secondary end points were toxicity, progression-free survival, and overall survival. Blood, tissue, and fecal samples were collected at multiple points for correlative studies to evaluate immunity biomarkers.ResultsFrom June 2019 to early study termination due to safety concerns on July 2020, 17 patients were enrolled (FUL: n=12, LET: n=5). One patient with a prior treatment history in the FUL cohort was excluded. ORRs were 54.5% (6/11) and 40.0% (2/5) in the FUL and LET cohorts, respectively. Treatment-emergent (TE) adverse events (AEs) of grade ≥3 occurred in 11 (92%) and 5 (100%) patients in the FUL and LET cohorts, respectively. The most common grade ≥3 TEAEs were neutropenia (7 (58.3%) and 3 (60.0%) in the FUL and LET cohorts, respectively), followed by alanine aminotransferase elevation (5 (41.6%) and 4 (80.0%)). One treatment-related death from interstitial lung disease occurred in the LET cohort. Ten patients developed liver-related grade ≥3 AEs. Liver biopsy specimens from 3 patients showed hepatitis characterized by focal necrosis with predominant CD8+ lymphocyte infiltration. Marked elevation of tumor necrosis factor-related cytokines and interleukin-11, and a decrease in peripheral regulatory T cells (Tregs), were observed in patients with hepatotoxicity. These findings suggest that treatment-related toxicities were immune-related AEs likely caused by proinflammatory cytokine production and suppression of Treg proliferation due to the addition of abemaciclib to nivolumab therapy.ConclusionsAlthough the combination of nivolumab and abemaciclib was active, it caused severe and prolonged immune-related AEs.Trial registration numberJapicCTI-194782, jRCT2080224706, UMIN000036970.
Cardiovascular events more than 6 months after pregnancy in patients with congenital heart disease
Authors: Schultz Hayley , Sobhani Nasim C , Blissett Sarah , Yogeswaran Vidhushei , Hong Jessica , Harris Ian S , Parikh Nisha , Gonzalez Juan , Agarwal Anushree 
Published: September 2023

ObjectivesPatients with congenital heart disease (CHD) are increasingly pursuing pregnancy, highlighting the need for data on late cardiovascular events (more than 6 months after delivery). We aimed to determine the incidence of late cardiovascular events in postpartum patients with CHD and evaluate the accuracy of the existing risk scores in predicting these events.Study designWe identified patients with CHD who delivered between 2008 and 2020 at a tertiary centre and had follow-up data for greater than 6 months post partum. Late cardiovascular events were defined as heart failure, arrhythmia, thromboembolic events, endocarditis, urgent cardiovascular interventions or death. Survival analysis and Cox proportional model were used to estimate the incidence of late cardiovascular events and determine the hazard ratio of factors associated with these events.ResultsOf 117 patients, 19% had 36 late cardiovascular events over a median follow-up of 3.8 years. Annual incidence of any late cardiovascular event was 5.7%. Hazards of late cardiovascular events were significantly higher among those with higher Cardiac Disease in Pregnancy Study (CARPREG) II and Zwangerschap bij Aangeboren HARtAfwijking-Pregnancy in Women With Congenital Heart Disease (ZAHARA) risk scores and among patients with prepregnancy New York Heart Association class≥II. C-statistic to predict the late cardiovascular events was highest for ZAHARA (0.7823), followed by CARPREG II (0.6902) and prepregnancy New York Heart Association class≥ II (0.6677).ConclusionsCurrently available risk tools designed for prognostication during the peripartum period can also be used to determine risks of late maternal cardiovascular events among those with CHD. These findings provide important new information for counselling and risk modification.
Anterior quadratus lumborum block for analgesia after living-donor renal transplantation: a double-blinded randomized controlled trial
Authors: Kim Youngwon , Kim Jin-Tae , Yang Seong-Mi , Kim Won Ho , Han Ahram , Ha Jongwon , Min Sangil , Park Sun-Kyung 
Published: September 2023

Introduction
Limited non-opioid analgesic options are available for managing postoperative pain after renal transplantation. We aimed to investigate whether the unilateral anterior quadratus lumborum (QL) block would reduce postoperative opioid consumption after living-donor renal transplantation in the context of multimodal analgesia.

Methods
Eighty-eight adult patients undergoing living-donor renal transplantation were randomly allocated to receive the unilateral anterior QL block (30 mL of ropivacaine 0.375%) or sham block (normal saline) on the operated side before emergence from anesthesia. All patients received standard multimodal analgesia, including the scheduled administration of acetaminophen and fentanyl via intravenous patient-controlled analgesia. The primary outcome was the total opioid consumption during the first 24 hours after transplantation. The secondary outcomes included pain scores, time to first opioid administration, cutaneous distribution of sensory blockade, motor weakness, nausea/vomiting, quality of recovery scores, time to first ambulation, and length of hospital stay.

Results
The total opioid consumption in the first 24 hours after transplantation did not differ significantly between the intervention and control groups (median (IQR), 160.5 (78–249.8) vs 187.5 (93–309) oral morphine milligram equivalent; median difference (95% CI), −27 (−78 to 24), p=0.29). No differences were observed in the secondary outcomes.

Conclusions
The anterior QL block did not reduce opioid consumption in patients receiving multimodal analgesia after living-donor renal transplantation. Our findings do not support the routine administration of the anterior QL block in this surgical population.

Trial registration number

NCT04908761
.
Fascial plane approach to anesthetizing the radial, median, and ulnar nerves: an educational review
Authors: Moody Alastair E , Miller Sarah T , Tupinio Maegan R , Newberry Cynthia M , Mangleson John , Swenson Jeffrey D 
Published: September 2023

Brachial plexus block provides effective anesthesia and analgesia for upper extremity surgery but requires injection of large anesthetic volumes near major vascular structures. Moreover, the extensive motor and sensory loss produced by plexus block often exceeds the neural distribution needed for corresponding surgical procedures.High-resolution ultrasound facilitates selective nerve blocks at nearly every level of the upper extremity. We present fascial plane injection techniques for selective radial, median, and ulnar nerve blocks. These techniques can be used to match sensory distribution with specific surgical procedures. They are performed using low anesthetic volumes and without proximity to nerves or vascular structures. In this article, fresh cadaver dissections with corresponding ultrasound images are used to demonstrate stepwise fascial plane techniques for the radial, median, and ulnar nerves. These techniques are performed using familiar anatomic landmarks.Practical applications of these techniques are demonstrated for commonly performed procedures of the upper extremity. Corresponding injection volumes with duration of postoperative analgesia are presented. Selected injections are described for both surgical anesthesia and postoperative analgesia.Selective fascial plane injections can provide surgical anesthesia and postoperative analgesia in settings that might otherwise require much larger volumes of local anesthetic. These selective nerve blocks can match sensory loss with the anatomic pain distribution in each patient. Reliable techniques for selective nerve blocks of the upper extremity can expand the capabilities for ultrasound-guided regional anesthesia.
Association between obesity and likelihood of remission or low disease activity status in psoriatic arthritis applying index-based and patient-based definitions of remission: a cross-sectional study
Authors: Leung Ying Ying , Eder Lihi , Orbai Ana-Maria , Coates Laura C , de Wit Maarten , Smolen Josef S , Kiltz Uta , Palominos Penélope , Canete Juan D , Scrivo Rossana , Balanescu Andra , Dernis Emanuelle , Meisalu Sandra , Soubrier Martin , Kalyoncu Umut , Gossec Laure 
Published: September 2023

ObjectivesWe aimed to evaluate whether obese patients with psoriatic arthritis (PsA) were less likely to be in remission/low disease activity (LDA).MethodsWe used data from the ReFlaP, an international multi-centre cohort study (NCT03119805), which recruited consecutive adults with definite PsA (disease duration ≥ 2 years) from 14 countries. Demographics, clinical data, comorbidities, and patient-reported outcomes were collected. Remission/LDA was defined as Very Low Disease Activity (VLDA)/minimal disease activity (MDA), Disease Activity in PSoriatic Arthritis (DAPSA) ≤4/≤14, or by patients’ opinion. Obesity was defined as physician-reported and/or body mass index ≥30 kg/m2. We evaluated the association between obesity and the presence of remission/LDA, with adjustment in multivariable regression models.ResultsAmong 431 patients (49.3% women), 136 (31.6%) were obese. Obese versus non-obese patients were older, more frequently women, had higher tender joint and enthesitis counts and worse pain, physical function and health-related quality of life. Obese patients were less likely to be in VLDA; DAPSA remission and MDA, with adjusted ORs of 0.31 (95% CI 0.13 to 0.77); 0.39 (95% CI 0.19 to 0.80) and 0.61 (95% CI 0.38 to 0.99), respectively. Rates of DAPSA-LDA and patient-reported remission/LDA were similar for obese and non-obese patients.ConclusionPsA patients with comorbid obesity were 2.5–3 folds less likely to be in remission/LDA by composite scores compared with non-obese patients; however, remission/LDA rates were similar based on the patients’ opinion. PsA patients with comorbid obesity may have different disease profiles and require individualised management.
Differential regulation of the interferon response in systemic lupus erythematosus distinguishes patients of Asian ancestry
Authors: Rector Ian , Owen Katherine A , Bachali Prathyusha , Hubbard Erika , Yazdany Jinoos , Dall'era Maria , Grammer Amrie C , Lipsky Peter E 
Published: September 2023

ObjectivesType I interferon (IFN) plays a role in the pathogenesis of systemic lupus erythematosus (SLE), but insufficient attention has been directed to the differences in IFN responses between ancestral populations. Here, we explored the expression of the interferon gene signatures (IGSs) in SLE patients of European ancestry (EA) and Asian ancestry (AsA).MethodsWe used gene set variation analysis with multiple IGS encompassing the response to both type 1 and type 2 IFN in isolated CD14+ monocytes, CD19+B cells, CD4+T cells and Natural Killer (NK) cells from patients with SLE stratified by self-identified ancestry. The expression of genes upstream of the IGS and influenced by lupus-associated risk alleles was also examined. Lastly, we employed machine learning (ML) models to assess the most important features classifying patients by disease activity.ResultsAsA patients with SLE exhibited greater enrichment in the IFN core and IFNA2 IGS compared with EA patients in all cell types examined and, in the presence and absence of autoantibodies. Overall, AsA patients with SLE demonstrated higher expression of genes upstream of the IGS than EA counterparts. ML with feature importance analysis indicated that IGS expression in NK cells, anti-dsDNA, complement levels and AsA status contributed to disease activity.ConclusionsAsA patients with SLE exhibited higher IGS than EA patients in all cell types regardless of autoantibody status, with enhanced expression of genetically associated genes upstream of the IGS potentially contributing. AsA, along with the IGS in NK cells, anti-dsDNA and complement, independently influenced SLE disease activity.
Virtual reality reduces anxiety and pain in acute hospital palliative care: service evaluation
Authors: Burridge Nancy , Sillence Alison , Teape Lynda , Clark Ben , Bruce Emma , Armoogum Julie , Leloch Daniella , Spathis Anna , Etkind Simon 
Published: September 2023

ObjectivesVirtual reality (VR) might improve symptom management, but there is limited evidence regarding VR in palliative care. We evaluated the feasibility of VR and impact on anxiety and pain for patients in a hospital palliative care consultation service.MethodsPatients referred to a hospital specialist palliative care team, with anxiety or pain, were offered a VR intervention (a short audiovisual experience). Participants rated anxiety and pain on a 0–10 Likert severity scale pre intervention/post intervention and completed an evaluation form. Change in symptom scores was analysed by parametric statistics.Results28 participants used VR a total of 42 times with no adverse events. Mean pain score reduced by 29% from 4.10 (SD=2.71) pre intervention to 2.93 (SD=2.45) post intervention (t(27)=5.150, p<0.001). Mean anxiety scores reduced by 40% from 4.43 (SD=2.56) to 2.65 (SD=2.24) (t(27)=5.058, p<0.001). Patients rated the experience on average 4.75/5 and all would recommend use to a friend. VR was described as absorbing and relaxing.ConclusionVR may improve anxiety and pain and was acceptable in this setting. Large-scale evaluation will generate important data on feasibility and implementation.
Trigger based on fuzzy logic for the detection of neutrino-induced extensive air showers in water-Cherenkov detectors
Authors: Szadkowski Zbigniew , Pytel Krzysztof 
Published: September 2023

AbstractA fuzzy logic trigger is an alternative approach to triggering a discrete cosine transform or a trigger based on artificial neural networks developed for the surface detector of the Pierre Auger Observatory. The aim of the article is to report on the development of estimators that would allow one distinguishing the signal profiles from the Auger photomultipliers of the water-Cherenkov detectors originating from the neutrino-induced atmospheric showers with a high background of the proton showers. Fuzzy Logic Toolbox provides MATLAB functions, apps, and a Simulink block for analyzing, designing, and simulating systems based on fuzzy logic. The next step is to implement trace recognition algorithms in the FPGA structure to generate a real-time trigger with reasonable use of FPGA resources and with sufficient time margin for 120 MHz sampling. The fuzzy logic trigger will support existing triggers in the Auger surface detector but is optimized to identify neutrino-generated showers. The next step in our research is the simulation of electromagnetic and hadronic cascades in the atmosphere, the propagation of Cherenkov light in the water detector, and the digitalization of the signals in the ADC if the preliminary results obtained from the artificially generated profiles are satisfactory.
Seminário interno Acervos na USP: desafios na gestão e na preservação
Authors: Silva Cibele Monteiro da , Urzua Flávia Andréa Machado , Hergert Ina , Arruda Isabela Ribeiro de , Saft Juliana Bechara , Azevedo Miriam Della Posta de 
Published: September 2023

Este relato apresenta a primeira ação do Grupo de Trabalho Acervos USP e Conservação, criado em novembro de 2022 pela direção do Centro de Preservação Cultural da USP (CPC-USP) e pela direção da Biblioteca Brasiliana Guita e José Mindlin (BBM-USP) agregando duas redes de profissionais de acervo já atuantes na Universidade de São Paulo, que são a Rede de Conservação Preventiva de Acervos e a Rede USP de Profissionais de Museus e Acervos. A ação relatada aqui é o seminário interno Acervos na USP: desafios na gestão e preservação, realizado nos dias 18 e 19 de abril de 2023, nas dependências da Biblioteca Brasiliana Guita e José Mindlin, campus Butantã, o qual reuniu profissionais das mais variadas unidades dos campi da Universidade que atuam diretamente com acervos, com o objetivo de compreender as condições atuais, entender as dificuldades e os pontos positivos e propor ações para a melhoria das condições de preservação e difusão do patrimônio cultural universitário.
Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies
SPP1
+
Macrophage Subpopulation as a Target for Alleviating Fibrosis
Authors: Fu Mengxia , Shu Songren , Peng Zhiming , Liu Xiaorui , Chen Xiao , Zeng Zhiwei , Yang Yicheng , Cui Hao , Zhao Ruojin , Wang Xiaohu , Du Leilei , Wu Min , Feng Wei , Song Jiangping 
Published: September 2023

BACKGROUND:
Perivascular adipose tissue (PVAT) is vital for vascular homeostasis, and PVAT dysfunction is associated with increased atherosclerotic plaque burden. But the mechanisms underlining coronary PVAT dysfunction in coronary atherosclerosis remain elusive.

METHODS:
We performed single-cell RNA sequencing of the stromal vascular fraction of coronary PVAT from 3 groups of heart transplant recipients with end-stage heart failure, including 3 patients with nonobstructive coronary atherosclerosis, 3 patients with obstructive coronary artery atherosclerosis, and 4 nonatherosclerosis control subjects. Bioinformatics was used to annotate the cellular populations, depict the cellular developmental trajectories and interactions, and explore the differences among 3 groups of coronary PVAT at the cellular and molecular levels. Pathological staining, quantitative real-time polymerase chain reaction, and in vitro studies were performed to validate the key findings.

RESULTS:

Ten cell types were identified among 67 936 cells from human coronary PVAT. Several cellular subpopulations, including
SPP1
+
(secreted phosphoprotein 1) macrophages and profibrotic fibroadipogenic progenitor cells, were accumulated in PVAT surrounding atherosclerotic coronary arteries compared with nonatherosclerosis coronary arteries. The fibrosis percentage was increased in PVAT surrounding atherosclerotic coronary arteries, and it was positively associated with the grade of coronary artery stenosis. Cellular interaction analysis suggested OPN (osteopontin) secreted by
SPP1
+
macrophages interacted with CD44 (cluster of differentiation 44)/integrin on fibroadipogenic progenitor cells. Strikingly, correlation analyses uncovered that higher level of SPP1 in PVAT correlates with a more severe fibrosis degree and a higher coronary stenosis grade. In vitro studies showed that conditioned medium from atherosclerotic coronary PVAT promoted the migration and proliferation of fibroadipogenic progenitor cells, while such effect was prevented by blocking CD44 or integrin.

CONCLUSIONS:

SPP1
+
macrophages accumulated in the PVAT surrounding atherosclerotic coronary arteries, and they promoted the migration and proliferation of fibroadipogenic progenitor cells via OPN-CD44/integrin interaction and thus aggravated the fibrosis of coronary PVAT, which was positively correlated to the coronary stenosis burden. Therefore,
SPP1
+
macrophages in coronary PVAT may participate in the progression of coronary atherosclerosis.
Endovascular Treatment in Acute Basilar Artery Occlusion Stroke: A Brief Practice Update From the Society of Vascular and Interventional Neurology
Authors: Asif Kaiz S. , Novakovic Robin , Nguyen Thanh N. , Mansour Ossama , deHavenon Adam , Masoud Hesham E. , Castonguay Alicia C. , Kenmuir Cynthia , Ashouri Yazan , Janardhan Vallabh , Liebeskind David S. , Hassan Ameer E. , Malik Amer M. , Zaidat Osama O. ,   for the SVIN GAPS Committee
Published: September 2023

Background
The Society of Vascular and Interventional Neurology Guidelines and Practice Standards committee established the “Brief Practice Update” format to provide up‐to‐date recommendations on focused relevant clinical questions. In this Brief Practice Update, we review current evidence and provide recommendations for endovascular treatment (EVT) in patients with acute large‐vessel occlusion of the basilar artery.

Methods
The Society of Vascular and Interventional Neurology Guidelines and Practice Standards committee conducted a systematic review, including the recent randomized clinical trials of EVT for acute ischemic stroke attributable to basilar artery occlusion, and summarized relevant data to provide recommendations for clinical practice. The Guidelines and Practice Standards quality committee reviewed the findings to ensure adherence to the Society of Vascular and Interventional Neurology internal evidence evaluation guidelines before review by the Society of Vascular and Interventional Neurology board members for societal endorsement.

Results
Evidence favors EVT for basilar artery occlusion in comparison to medical management alone in patients with moderate to severe stroke. We formulated the level of evidence and the class of recommendation in the context of 5 clinical questions.

Conclusions
In this brief practice statement, we share general recommendations on EVT for acute ischemic stroke attributable to large‐vessel occlusion of the basilar artery. Recent randomized controlled trials, Basilar Artery Occlusion Chinese Endovascular (BAOCHE) trial and Endovascular Treatment for Acute Basilar‐Artery Occlusion (ATTENTION), and a meta‐analysis of all randomized controlled trials support EVT in patients with moderate to severe basilar artery occlusion stroke symptoms.
How NGOs May Promote a Shared Society in Conflict-Affected Areas
Authors: Binhas Adi , Jayusi Wurud , Hajisoteriou Christina 
Published: September 2023

Abstract
This article comparatively examines the results of a qualitative study of how non-governmental organizations (NGOs) may promote a shared society in the conflict-affected areas of Israel and Cyprus. The authors have chosen to set their research in these two contexts, where the complex relationships between the majority and the minority communities have led to persistent conflicts that seem rather ‘intractable’ and ‘frozen’. Three thematic categories emerge from this analysis: (a) empowering citizens to enact intercultural initiatives; (b) enhancing youth’s agency; and (c) collaborating with the state and other actors. The authors discuss their findings under the framework of interculturalism and intercultural change. Their argument is that for peacebuilding to flourish in both countries, civil society organizations (CSOs) should cultivate sympathetic imagination by enabling people from the communities in conflict to firstly imagine and then pursue alternatives to the current status quo.