bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D scanning of Upper Limb anatomy by a depth-camera-based system
Authors: Neri Paolo , Paoli Alessandro , Aruanno Beatrice , Barone Sandro , Tamburrino Francesco , Razionale Armando V. 
Published: February 2023

AbstractThe 3D reconstruction of upper limb anatomy plays a significant role in many biomedical fields such as ergonomics, motion rehabilitation, and prosthesis design. In the last few years, the technical advancement of consumer-grade depth cameras has supported the development of portable and low-cost optical 3D body scanners for healthcare applications. The real-time scanning of human body parts, however, still represents a complex task due to the non-stationary nature of the scanning target. This issue imposes that the scanning time must be reduced as much as possible to minimize scanning artifacts. In this regard, depth cameras can capture geometrical information at video frame rates, thus guaranteeing fast acquisition times. Furthermore, the simultaneous use of multiple sensors would minimize undercut geometries, which impair the 3D reconstruction’s completeness. In this work, a portable 3D optical scanner has been developed by rigidly assembling three Intel® RealSense™ D415 depth cameras on a lightweight circular frame. The three sensors are mutually calibrated, by using a 3D printed calibration specimen, to simultaneously align acquisitions from the three different camera viewpoints for each scanner pose. The system’s effectiveness has been assessed by acquiring the geometry of both a plaster hand and a human hand and comparing the results with those obtained by a high-end stationary structured light scanner. The developed system represents a low-cost handheld alternative to existing body scanners for collecting and storing 3D anatomical data, which can be used in the design process of bespoke medical devices.
Feasibility of the Palliative Care Education in Assisted Living Intervention for Dementia Care Providers: A Cluster Randomized Trial
Authors: Dobbs Debra , Yauk Jessica , Vogel Carlyn E , Fanfan Dany , Buck Harleah , Haley William E , Meng Hongdao 
Published: February 2023

Abstract

Background and Objectives
Alzheimer’s disease and related dementia (ADRD) is a major cause of death in the United States. While effective interventions have been developed to deliver palliative care to nursing home residents with ADRD, little work has identified effective interventions to reach assisted living (AL) residents with dementia.

Research Design and Methods
One hundred and eighteen AL residents with dementia from 10 different ALs in Florida participated. A pilot study using a cluster randomized trial was conducted, with 6 sites randomized to receive a palliative care educational intervention for staff (N = 23) to deliver care to residents; 4 sites were usual care. The feasibility of the intervention was assessed by examining recruitment, retention, and treatment fidelity at 6 months. Cohen’s d statistic was used to calculate facility-level treatment effect sizes on key outcomes (documentation of advance care planning [ACP] discussions, hospice admission, and documentation of pain screening).

Results
The intervention proved feasible with high ratings of treatment fidelity. The intervention also demonstrated preliminary evidence for efficacy of the intervention, with effect sizes for the treatment group over 0.80 for increases in documentation of ACP discussions compared to the control group. Hospice admissions had a smaller effect size (0.16) and documentation of pain screenings had no effect.

Discussion and Implications
The pilot results suggest that the intervention shows promise as a resource for educating and empowering AL staff on implementing person-centered palliative care delivery to persons with dementia in AL. A larger, fully powered randomized trial is needed to test for its efficacy.
Integrating evidence-based teaching practices into the Mammalogy classroom
Authors: Patrick Lorelei E , Duggan Jennifer M , Dizney Laurie 
Published: February 2023

Abstract
The teaching practices used in college science classrooms have a profound influence on which students pass their courses (and continue to major in science) and which are ‘weeded out.’ Students from traditionally marginalized backgrounds have lower grades and learning gains compared to their nonmarginalized peers in courses that rely heavily on lecture and high-stakes exams. This achievement gap narrows or disappears when instructors use student-centered, evidence-based teaching practices. These teaching practices can include actions that shape our classroom environment, communicate course material, and assess student learning. In this paper, we provide a summary of the evidence supporting the use of student-centered teaching practices, followed by examples of several effective evidence-based teaching practices that can be integrated into organismal courses. Examples include faculty mindset for inclusion, teaching practices to increase student confidence and to reduce stereotype threat, increasing course structure by spreading points among several different types of activities, several active learning methods, jigsaws, Scientist Spotlights, course-based undergraduate research experiences, and inquiry-based labs. Each example is linked to supporting resources to help instructors easily implement these practices in their classrooms. The American Society of Mammalogists endeavors to be equitable and inclusive through numerous initiatives, and modifying our teaching practices can increase equity and inclusion of future mammalogists into our own classrooms.
Assessing the Utility of ChatGPT Throughout the Entire Clinical Workflow
Authors: Rao Arya , Pang Michael , Kim John , Kamineni Meghana , Lie Winston , Prasad Anoop K. , Landman Adam , Dreyer Keith J , Succi Marc D. 
Published: February 2023

AbstractIMPORTANCELarge language model (LLM) artificial intelligence (AI) chatbots direct the power of large training datasets towards successive, related tasks, as opposed to single-ask tasks, for which AI already achieves impressive performance. The capacity of LLMs to assist in the full scope of iterative clinical reasoning via successive prompting, in effect acting as virtual physicians, has not yet been evaluated.OBJECTIVETo evaluate ChatGPT’s capacity for ongoing clinical decision support via its performance on standardized clinical vignettes.DESIGNWe inputted all 36 published clinical vignettes from the Merck Sharpe & Dohme (MSD) Clinical Manual into ChatGPT and compared accuracy on differential diagnoses, diagnostic testing, final diagnosis, and management based on patient age, gender, and case acuity.SETTINGChatGPT, a publicly available LLMPARTICIPANTSClinical vignettes featured hypothetical patients with a variety of age and gender identities, and a range of Emergency Severity Indices (ESIs) based on initial clinical presentation.EXPOSURESMSD Clinical Manual vignettesMAIN OUTCOMES AND MEASURESWe measured the proportion of correct responses to the questions posed within the clinical vignettes tested.RESULTSChatGPT achieved 71.7% (95% CI, 69.3% to 74.1%) accuracy overall across all 36 clinical vignettes. The LLM demonstrated the highest performance in making a final diagnosis with an accuracy of 76.9% (95% CI, 67.8% to 86.1%), and the lowest performance in generating an initial differential diagnosis with an accuracy of 60.3% (95% CI, 54.2% to 66.6%). Compared to answering questions about general medical knowledge, ChatGPT demonstrated inferior performance on differential diagnosis (β=-15.8%, p<0.001) and clinical management (β=-7.4%, p=0.02) type questions.CONCLUSIONS AND RELEVANCEChatGPT achieves impressive accuracy in clinical decision making, with particular strengths emerging as it has more clinical information at its disposal.
Sex-specific Morphometric Analysis of Ascending Aorta and Aortic Arch for Planning Thoracic Endovascular Aortic Repair
Authors: Katsarou Maria , Mandigers Tim J. , Berczeli Marton , Zubair M. Mujeeb , Belvroy Viony M. , Schwein Adeline , Bissacco Daniele , van Herwaarden Joost A , Trimarchi Santi , Bismuth Jean 
Published: February 2023

AbstractBackgroundIn many studies on aortic disease women are underrepresented. The present study aims to assess sex-specific morphometric differences and gain more insight into endovascular treatment of the AA and arch.MethodsElectrocardiogram-gated cardiac computed tomography scans of 116 patients who were evaluated for transcatheter aortic valve replacement were retrospectively reviewed. Measurements of the AA and aortic arch were made in multiplanar views, perpendicular to the semi-automatic centerline. Multiple linear regression analysis was performed to identify predictors affecting AA and aortic arch diameter in men and women. Propensity score matching was used to investigate whether sex influences aortic morphology.ResultsIn both sexes, body surface area (BSA) was identified as a positive predictor and diabetes as a negative predictor for aortic diameters. In men, age was identified as a positive predictor and smoking as a negative predictor for aortic diameters. Propensity score matching identified 40 pairs. Systolic and diastolic mean diameters and AA length were significantly wider in men. On average, male aortas were 7,4% wider compared to female aortas, both in systole and diastole.ConclusionsThe present analysis demonstrates that, in women, increased BSA is associated with increased aortic arch diameters, while diabetes is associated to decreased AA and arch diameters. In men, increased body surface area and age are associated to increased AA and arch diameters, while smoking and diabetes are associated to decreased AA and arch diameters. Men were confirmed to have 7.4% greater AA and arch diameters than women.
Quantifying the impact of SARS-CoV-2 temporal vaccination trends and disparities on disease control
Authors: Larsen Sophie L. , Shin Ikgyu , Joseph Jefrin , West Haylee , Anorga Rafael , Mena Gonzalo E. , Mahmud Ayesha S. , Martinez Pamela P. 
Published: February 2023

AbstractSARS-CoV-2 vaccines were developed and distributed during a global crisis at unprecedented speed. Still, little is known about trends in vaccine uptake over time, their association with socioeconomic inequality, and the impact of these temporal trends on disease control. By analyzing data from dozens of countries, we examined vaccination rates across high and low socioeconomic (SES) groups, showing that socioeconomic disparities in the fraction of the population vaccinated exist at both national and sub-national levels. We also identified two distinct vaccination trends: one characterized by rapid initial roll-out, quickly reaching a plateau; and another trend that is sigmoidal and slow to begin. Informed by these patterns, we implemented an SES-stratified mechanistic model, finding profound differences across the two vaccination types in the burden of infections and deaths. The timing of initial roll-out has a more significant effect on transmission and deaths than the eventual level of coverage or the degree of SES disparity. Surprisingly, the speed of the roll-out is not associated with wealth inequality or GDP per capita of countries. While socioeconomic disparity should be addressed, accelerating the initial roll-out for all groups is a broadly accessible intervention and has the potential to minimize the burden of infections and deaths across socioeconomic groups.
Safety of the NVX-CoV2373 COVID-19 Vaccine in Randomized Placebo-Controlled Clinical Trials
Authors: Smith Katherine , Hegazy Karim , Cai Miranda R. , McKnight Irene , Rousculp Matthew D. , Alves Katia 
Published: February 2023

AbstractBackgroundNVX-CoV2373 (Nuvaxovid™ or the Novavax COVID-19 Vaccine, Adjuvanted), the first protein-based COVID-19 vaccine, received emergency use authorization (EUA) as a primary series/booster and is available globally. NVX-CoV2373 primary series demonstrated efficacy rates of 89·7–90·4 % and an acceptable safety profile. This article summarizes safety in adult recipients (aged ≥18 years) of primary series NVX-CoV2373 in four randomized placebo-controlled trials.MethodsAll participants who received NVX-CoV2373 primary series or placebo (pre-crossover) were included according to actual received treatment. The safety period was from Day 0 (first vaccination) to unblinding/receipt of EUA-approved/crossover vaccine, end of each study (EOS), or last visit date/cutoff date minus 14 days. The analysis reviewed local and systemic solicited adverse events (AEs) within 7 days after NVX-CoV2373 or placebo; unsolicited AEs from after Dose 1 to 28 days after Dose 2; serious AEs (SAEs), deaths, AEs of special interest, and vaccine-related medically attended AEs from Day 0 through end of follow-up (incidence rate per 100 person-years).FindingsPooled data from 49,950 participants (NVX-CoV2373, n=30,058; placebo, n=19,892) were included. Solicited reactions after any dose were more frequent in NVX-CoV2373 recipients (local, 76%/systemic, 70%) than placebo recipients (29%/47%), and were mostly of mild-to-moderate severity. Grade 3+ reactions were infrequent, with greater frequency in NVX-CoV2373 recipients (6·28%/11·36%) than placebo recipients (0·48%/3·58%). SAEs and deaths occurred with similarly low frequency in NVX-CoV2373 (0·91% and 0·07%, respectively) and placebo recipients (1·0% and 0·06%).InterpretationTo date, NVX-CoV2373 has displayed an acceptable safety profile in healthy adults.FundingSupported by Novavax, Inc.
Sensory profiling in classical Ehlers-Danlos syndrome: a case-control study revealing pain characteristics, somatosensory changes, and impaired pain modulation
Authors: Colman Marlies , Syx Delfien , de Wandele Inge , Rombaut Lies , Wille Deborah , Malfait Zoë , Meeus Mira , Malfait Anne-Marie , Van Oosterwijck Jessica , Malfait Fransiska 
Published: February 2023

AbstractPain is one of the most important, yet poorly understood complaints in heritable connective tissue disorders (HCTD) caused by monogenic defects in extracellular matrix molecules. This is particularly the case for Ehlers-Danlos syndromes (EDS), paradigm collagen-related disorders. This study aimed to identify the pain signature and somatosensory characteristics in the rare classical type of EDS (cEDS) caused by defects in type V or rarely type I collagen. We used static and dynamic quantitative sensory testing and validated questionnaires in 19 individuals with cEDS and 19 matched controls.Individuals with cEDS reported clinically relevant pain/discomfort (VAS ≥5/10 in 32% for average pain intensity the past month) and worse health -related quality of life. Altered sensory profile was found in the cEDS group with higher (p=0.04) detection thresholds for vibration stimuli at the lower limb indicating hypoesthesia, reduced thermal sensitivity with more (p<0.001) paradoxical thermal sensations, and hyperalgesia with lower pain thresholds to mechanical (p<0.001) stimuli at both the upper and lower limbs and to cold (p=0.005) stimulation at the lower limb. Using a parallel conditioned pain paradigm, the cEDS group showed significantly smaller antinociceptive responses (p-value between 0.005 and 0.046) suggestive of impaired endogenous central pain modulation.In conclusion, Individuals with cEDS report chronic pain and worse health-related quality of life, and present altered somatosensory perception. This study is the first to systematically investigate pain and somatosensory characteristics in a genetically defined HCTD and provides interesting insights on the possible role of the ECM in the development and persistence of pain.
A High-Throughput Microfluidic Quantitative PCR Platform for the Simultaneous Quantification of Pathogens, Fecal Indicator Bacteria, and Microbial Source Tracking Markers
Authors: Hill Elizabeth R. , Chun Chan Lan , Hamilton Kerry , Ishii Satoshi 
Published: February 2023

AbstractContamination of water with bacterial, viral, and protozoan pathogens can cause human diseases. Both humans and non-humans can release these pathogens through their feces. To identify the sources of fecal contamination in the water environment, microbial source tracking (MST) approaches have been developed; however, the relationship between MST markers and pathogens is still not well understood most likely due to the lack of comprehensive datasets of pathogens and MST marker concentrations. In this study, we developed a novel microfluidic quantitative PCR (MFQPCR) platform for the simultaneous quantification of MST markers, fecal indicator bacteria (FIB), and bacterial, viral, and protozoan pathogens in many samples. A total of 80 previously validated TaqMan probe assays were applied on the MFQPCR chips, including those for two FIB, 22 bacterial pathogens, 11 viral pathogens, five protozoan pathogens, 37 MST markers for various host species, and three process controls. Specific and sensitive detection was verified for most assays on the MFQPCR platform. The MFQPCR chip was applied to analyze pathogen removal rates during the wastewater treatment processes. In addition, multiple host-specific MST markers, FIB, and pathogens were successfully quantified in human and avian-impacted surface waters. While the genes for pathogens were relatively infrequently detected, positive correlations were observed between some potential pathogens such asClostridium perfringensandMycobacteriumspp., and human MST markers. The MFQPCR chips developed in this study, therefore, can provide useful information to monitor and improve water quality.
Short Tandem Repeat Profiling via Next Generation Sequencing for Cell Line Authentication
Authors: Chen Yi-Hsien , Connelly Jon P. , Florian Colin , Cui Xiaoxia , Pruett-Miller Shondra M. 
Published: February 2023

AbstractCell lines are indispensable models for modern biomedical research. In the era of CRISPR gene editing, they serve as versatile tools for preclinical studies, allowing patient specific mutations to be modeled or corrected and the resulting phenotypic outcomes studied. A large part of their usefulness derives from the ability of a cell line to proliferate over multiple passages (often indefinitely) allowing multiple experiments to be performed. However, over time, the cell line identity and purity can be compromised by human errors. Both cross contamination from other cell lines and even complete misidentification are possible. Routine cell line authentication is a necessary preventive measure and has become a requirement for many funding applications and publications. Short tandem repeat (STR) profiling is the most common method for cell line authentication and is usually carried out using standard polymerase chain reaction (PCR)-capillary electrophoresis (CE) analysis (STR-CE). Here we evaluated next generation sequencing (NGS)-based STR profiling of human and mouse cell lines at 18 and 15 loci, respectively, in a high-throughput format. Using the program STRight written in Python, we demonstrate that NGS-based analysis (STR-NGS) is superior to standard STR-CE in terms of the ability to report the sequence context of repeat motifs, sensitivity, and flexible multiplexing capability. STR-NGS is a valuable alternative for cell line authentication.
Prioritisation of bridge for improving its resilience using multi-criteria decision-making techniques
Authors: Lad V.H. , Patel D.A. , Chauhan K.A. , Patel K.A. 
Published: February 2023

PurposeThe work on bridge resilience assessment includes quantitative and qualitative approaches to compare the multiple bridges based on their resilience. But still, the bridge resilience obtained by these assessment approaches is inefficient when prioritising multiple bridges to improve their resilience. Therefore, this study aims to develop a methodology for prioritising the bridges to improve their resilience.Design/methodology/approachThe research methodology follows three sequential phases. In the first phase, criteria importance through intercriteria correlation (CRITIC) technique is used to compute the criteria weights. The criteria considered are age, area, design high flood level, finish road level FRL and resilience index of bridges. While 12 river-crossing bridges maintained by one bridge owner are considered as alternatives. Then, in the second phase, the prioritisation of each bridge is evaluated using five techniques, including technique for order of preference by similarity to ideal solution, VIKOR (in Serbian, Visekriterijumska Optimizacija I Kompromisno Resenje), additive ratio assessment, complex proportional assessment and multi-objective optimisation method by ratio analysis. Finally, in the third phase, the results of all five techniques are integrated using CRITIC and the weighted sum method.FindingsThe result of the study enables bridge owners to deal with the particular bridge that requires resilience improvement. The study concluded that it is not enough to consider only the bridge resilience index to improve its resilience. The prioritisation exercise should consider various other criteria that are not preferred during the bridge resilience assessment process.Originality/valueThe proposed methodology is a novel framework based on the existing multi-criteria decision-making (MCDM) techniques for contributing knowledge in the domain of bridge resilience management. It can efficiently overcome the pitfall of decision-making when two bridges have the same resilience index score.
The impact of proactive personality and psychological capital on innovative work behavior: evidence from software houses of Pakistan
Authors: Ullah Irfan , Hameed Raja Mazhar , Mahmood Abid 
Published: February 2023

PurposeThe purpose of the contemporary research study is to develop and empirically investigate antecedents of innovative work behavior (IWB) in organizations by applying the broaden-and-build theory, associating both personal and contextual factors in encouraging employees' IWB.Design/methodology/approachA conceptual model has been developed, examining the influence of proactive personality and psychological capital (PsyCap) on innovative performance. Data were collected through an in-person administered questionnaire-based survey from the employees working in the software houses of Pakistan.FindingsThe analysis revealed that proactive personality and PsyCap have a significant impact on employee innovative performance, given that proactive personality and PsyCap are the critical antecedents of IWB.Originality/valueThis contemporary research study is original and will impart constructive contribution for a substantial number of reasons. First, this research study provides suggestions on proactive personality, which relate remarkably to innovative work behavior. Second, this research study observes the relationship between several organizational aspects and employees' creativity for the evaluation and advancement in the results of prior classic research studies conducted in the given field. This research study integrates both personal and organizational dynamics to evaluate the innovative and creative ability not only in the perspective of multinational, but also in the national corporations.