bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of long-term data on surface contamination by antineoplastic drugs in pharmacies
Authors: Quartucci Caroline , Rooney James P. K. , Nowak Dennis , Rakete Stefan 
Published: March 2023

Abstract
Purpose
The handling of antineoplastic drugs represents an occupational health risk for employees in pharmacies. To minimize exposure and to evaluate cleaning efficacy, wipe sampling was used to analyze antineoplastic drugs on surfaces. In 2009, guidance values were suggested to facilitate the interpretation of results, leading to a decrease in surface contamination. The goal of this follow-up was to evaluate the time trend of surface contamination, to identify critical antineoplastic drugs and sampling locations and to reassess guidance values.

Methods
Platinum, 5-fluorouracil, cyclophosphamide, ifosfamide, gemcitabine, methotrexate, docetaxel and paclitaxel were analyzed in more than 17,000 wipe samples from 2000 to 2021. Statistical analysis was performed to describe and interpret the data.

Results
Surface contaminations were generally relatively low. The median concentration for most antineoplastic drugs was below the limit of detection except for platinum (0.3 pg/cm2). Only platinum and 5-fluorouracil showed decreasing levels over time. Most exceedances of guidance values were observed for platinum (26.9%), cyclophosphamide (18.5%) and gemcitabine (16.6%). The most affected wipe sampling locations were isolators (24.4%), storage areas (17.6%) and laminar flow hoods (16.6%). However, areas with no direct contact to antineoplastic drugs were also frequently contaminated (8.9%).

Conclusion
Overall, the surface contaminations with antineoplastic drugs continue to decrease or were generally at a low level. Therefore, we adjusted guidance values according to the available data. The identification of critical sampling locations may help pharmacies to further improve cleaning procedure and reduce the risk of occupational exposure to antineoplastic drugs.
Proposing an ensemble machine learning based drought vulnerability index using M5P, dagging, random sub-space and rotation forest models
Authors: Saha Sunil , Kundu Barnali , Paul Gopal Chandra , Pradhan Biswajeet 
Published: March 2023

AbstractDrought is one of the major barriers to the socio-economic development of a region. To manage and reduce the impact of drought, drought vulnerability modelling is important. The use of an ensemble machine learning technique i.e. M5P, M5P -Dagging, M5P-Random SubSpace (RSS) and M5P-rotation forest (RTF) to assess the drought vulnerability maps (DVMs) for the state of Odisha in India was proposed for the first time. A total of 248 drought-prone villages (samples) and 53 drought vulnerability indicators (DVIs) under exposure (28), sensitivity (15) and adaptive capacity (10) were used to produce the DVMs. Out of the total samples, 70% were used for training the models and 30% were used for validating the models. Finally, the DVMs were authenticated by the area under curve (AUC) of receiver operating characteristics, precision, mean-absolute-error, root-mean-square-error, K-index and Friedman and Wilcoxon rank test. Nearly 37.9% of the research region exhibited a very high to high vulnerability to drought. All the models had the capability to model the drought vulnerability. As per the Friedman and Wilcoxon rank test, significant differences occurred among the output of the ensemble models. The accuracy of the M5P base classifier improved after ensemble with RSS and RTF meta classifiers but reduced with Dagging. According to the validation statistics, M5P-RFT model achieved the highest accuracy in modelling the drought vulnerability with an AUC of 0.901. The prepared model would help planners and decision-makers to formulate strategies for reducing the damage of drought.
Residual motion of cortical versus pedicle screw constructs after decompression, interbody fusion and cross-link augmentation
Authors: Burkhard Marco D. , Cornaz Frédéric , Spirig José Miguel , Wanivenhaus Florian , Fasser Marie-Rosa , Widmer Jonas , Farshad Mazda 
Published: March 2023

Abstract
Purpose
To compare the residual range of motion (ROM) of cortical screw (CS) versus pedicle screw (PS) instrumented lumbar segments and the additional effect of transforaminal interbody fusion (TLIF) and cross-link (CL) augmentation.

Methods
ROM of thirty-five human cadaver lumbar segments in flexion/extension (FE), lateral bending (LB), lateral shear (LS), anterior shear (AS), axial rotation (AR), and axial compression (AC) was recorded. After instrumenting the segments with PS (n = 17) and CS (n = 18), ROM in relation to the uninstrumented segments was evaluated without and with CL augmentation before and after decompression and TLIF.

Results
CS and PS instrumentations both significantly reduced ROM in all loading directions, except AC. In undecompressed segments, a significantly lower relative (and absolute) reduction of motion in LB was found with CS 61% (absolute 3.3°) as compared to PS 71% (4.0°; p = 0.048). FE, AR, AS, LS, and AC values were similar between CS and PS instrumented segments without interbody fusion. After decompression and TLIF insertion, no difference between CS and PS was found in LB and neither in any other loading direction. CL augmentation did not diminish differences in LB between CS and PS in the undecompressed state but led to an additional small AR reduction of 11% (0.15°) in CS and 7% (0.05°) in PS instrumentation.

Conclusion
Similar residual motion is found with CS and PS instrumentation, except of slightly, but significantly inferior reduction of ROM in LB with CS. Differences between CS and PS in diminish with TLIF but not with CL augmentation.
Cranial meningioma with bone involvement: surgical strategies and clinical considerations
Authors: Clynch Abigail L. , Norrington Max , Mustafa Mohammad A. , Richardson George E. , Doherty John A. , Humphries Thomas J. , Gillespie Conor S. , Keshwara Sumirat M. , McMahon Catherine J. , Islim Abdurrahman I. , Jenkinson Michael D. , P. Millward Christopher , Brodbelt Andrew R. 
Published: March 2023

Abstract
Background
Intracranial meningioma with bone involvement and primary intraosseous meningioma is uncommon. There is currently no consensus for optimal management. This study aimed to describe the management strategy and outcomes for a 10-year illustrative cohort, and propose an algorithm to aid clinicians in selecting cranioplasty material in such patients.

Methods
A single-centre, retrospective cohort study (January 2010–August 2021). All adult patients requiring cranial reconstruction due to meningioma with bone involvement or primary intraosseous meningioma were included. Baseline patient and meningioma characteristics, surgical strategy, and surgical morbidity were examined. Descriptive statistics were performed using SPSS v24.0. Data visualisation was performed using R v4.1.0.

Results
Thirty-three patients were identified (mean age 56 years; SD 15) There were 19 females. Twenty-nine patients had secondary bone involvement (88%). Four had primary intraosseous meningioma (12%). Nineteen had gross total resection (GTR; 58%). Thirty had primary ‘on-table’ cranioplasty (91%). Cranioplasty materials included pre-fabricated polymethyl methacrylate (pPMMA) (n = 12; 36%), titanium mesh (n = 10; 30%), hand-moulded polymethyl methacrylate cement (hPMMA) (n = 4; 12%), pre-fabricated titanium plate (n = 4; 12%), hydroxyapatite (n = 2; 6%), and a single case combining titanium mesh with hPMMA cement (n = 1; 3%). Five patients required reoperation for a postoperative complication (15%).

Conclusion
Meningioma with bone involvement and primary intraosseous meningioma often requires cranial reconstruction, but this may not be evident prior to surgical resection. Our experience demonstrates that a wide variety of materials have been used successfully, but that pre-fabricated materials may be associated with fewer postoperative complications. Further research within this population is warranted to identify the most appropriate operative strategy.
Defensive and offensive behaviours in a Kleefstra syndrome mouse model
Authors: Alonso Alejandra , Samanta Anumita , van der Meij Jacqueline , van den Brand Liz , Negwer Moritz , Navarro Lobato Irene , Genzel Lisa 
Published: March 2023

AbstractKleefstra syndrome in humans is characterized by a general delay in development, intellectual disability and autistic features. The mouse model of this disease (Ehmt1±) expresses anxiety, autistic-like traits, and aberrant social interactions with non-cagemates. To investigate how Ehmt1± mice behave with unfamiliar conspecifics, we allowed adult, male animals to freely interact for 10 min in a neutral, novel environment within a host-visitor setting. In trials where the Ehmt1± mice were hosts, there were defensive and offensive behaviors. Our key finding was that Ehmt1± mice displayed defensive postures, attacking and biting; in contrast, wild-type (WT) interacting with other WT did not enact such behaviors. Further, if there was a fight between an Ehmt1± and a WT mouse, the Ehmt1± animal was the most aggressive and always initiated these behaviors.
Staphylococcus aureus hitchhiking from colonization to bacteremia via Candida within ICU infection prevention studies: a proof of concept modelling
Authors: Hurley James C. 
Published: March 2023

AbstractWhether Candida within the patient microbiome drives the pathogenesis of Staphylococcus aureus bacteremia, described as microbial hitchhiking, cannot be directly studied. Group-level observations from studies of various decontamination and non-decontamination-based ICU infection prevention interventions and studies without study interventions (observational groups) collectively enable tests of this interaction within causal models. Candidate models of the propensity for Staphylococcus aureus bacteremia to arise with versus without various antibiotic, anti-septic, and antifungal exposures, each identified as singleton exposures, were tested using generalized structural equation modelling (GSEM) techniques with Candida and Staphylococcus aureus colonization appearing as latent variables within the models. Each model was tested by confrontation against blood and respiratory isolate data, obtained from 467 groups within 284 infection prevention studies. Introducing an interaction term between Candida colonization and Staphylococcus aureus colonization substantially improved GSEM model fit. Model-derived coefficients for singular exposure to anti-septic agents (− 1.28; 95% confidence interval; − 2.05 to − 0.5), amphotericin (− 1.49; − 2.3 to − 0.67), and topical antibiotic prophylaxis (TAP; + 0.93; + 0.15 to + 1.71) as direct effects versus Candida colonization were similar in magnitude but contrary in direction. By contrast, the coefficients for singleton exposure to TAP, as with anti-septic agents, versus Staphylococcus colonization were weaker or non-significant. Topical amphotericin would be predicted to halve both candidemia and Staphylococcus aureus bacteremia incidences versus literature derived benchmarks for absolute differences of < 1 percentage point. Using ICU infection prevention data, GSEM modelling validates the postulated interaction between Candida and Staphylococcus colonization facilitating bacteremia.
Interactions between the individual and the group level in organizations: The case of learning and group turnover
Authors: Blanco-Fernández Darío , Leitner Stephan , Rausch Alexandra 
Published: March 2023

AbstractPrevious research on organizations often focuses on either the individual, team, or organizational level. There is a lack of multidimensional research on emergent phenomena and interactions between the mechanisms at different levels. This paper takes a multifaceted perspective on individual learning and autonomous group formation. To analyze interactions between the two levels, we introduce an agent-based model that captures an organization with a population of heterogeneous agents who learn and are limited in their rationality. To solve a task, agents form a group which experiences turnover from time to time, i.e., its composition changes periodically. We explore organizations that promote learning and changes in group composition either simultaneously or sequentially and analyze the interactions between the activities and the effects on performance. We observe underproportional interactions when tasks are interdependent and show that pushing learning and group turnover too far might backfire and decrease performance significantly.
Introduced rabbits as seed-dispersing frugivores: a study case on a environmentally diverse oceanic island (Tenerife, Canaries)
Authors: Guerrero-Campos María , Mendes Sara Beatriz , Marrero Patricia , Romero Javier , Nieves Concepción , Hervías-Parejo Sandra , González-Mancebo Juana María , Nogales Manuel 
Published: March 2023

AbstractRabbits have travelled with humans to the most remote archipelagos, having been introduced on at least 800 islands worldwide. This herbivore has caused a devastating effect on endemic insular plants, causing changes in species composition, cascading extinctions and disruption of native seed dispersal systems worldwide. However, its ecological impacts as disrupting native seed dispersal systems have not been studied from a holistic perspective in any of the archipelagos where rabbits were introduced. Here, we assess the role of rabbits as frugivores and seed-dispersers on the most extensive and diverse island of the Canary Archipelago, Tenerife, across its five main vegetation zones represented in an altitudinal gradient 0–3715 m a.s.l. To this end, 120 transects per vegetation zone were conducted (August 2020–November 2021) to collect fresh faecal samples from a total of 244 latrines. They consisted of 29,538 droppings in which we found seeds from 73 plant species, 29 of which were identified to species level (13 endemic, eight natives and eight introduced by humans). About 70% of the seeds were identified as fleshy-fruited plant species while the remaining nine were dry fruits. Of the former, only nine showed a percentage of intact seeds greater than 75%, another nine species between 50 and 75%, and three lower than 50%. The digestive effect of rabbits on seedling emergence was generally low, compared to that produced by native seed dispersers. Since fleshy-fruited plants and rabbits have not been linked in their evolutionary history in the Canaries, the former seems to have their own legitimate seed dispersers.
How Do Dust Devil-Like Vortices Depend on Model Resolution? A Grid Convergence Study Using Large-Eddy Simulation
Authors: Giersch Sebastian , Raasch Siegfried 
Published: March 2023

AbstractDust devils are organized convective vortices with pressure drops of hundreds of pascals that spirally lift surface material into the air. This material modifies the radiation budget by contributing to the atmospheric aerosol concentration. Quantification of this contribution requires good knowledge of the dust devil statistics and dynamics. The latter can also help to understand vortex genesis, evolution and decay, in general. Dust devil-like vortices are numerically investigated mainly by large-eddy simulation (LES). A critical parameter in these simulations is the grid spacing, which has a great influence on the dust devil statistics. So far, it is unknown which grid size is sufficient to capture dust devils accurately. We investigate the convergence of simulated convective vertical vortices that resemble dust devils by using the LES model PALM. We use the nesting capabilities of PALM to explore grid spacings from 10 to 0.625 m. Grid spacings of 1 m or less have never been used for the analysis of dust devil-like vortices that develop in a horizontal domain of more than 10 km$$^2$$2. Our results demonstrate that a minimum resolution of 1.25 m is necessary to achieve a convergence for sample-averaged quantities like the core pressure drop. This grid spacing or smaller should be used for future quantifications of dust devil sediment fluxes. However, sample maxima of the investigated dust devil population and peak velocity values of the general flow show no convergence. If a qualitative description of the dust devil flow pattern is sufficient, we recommend a grid spacing of 2.5 m or smaller.
Pegylated liposomal doxorubicin (Duomeisu®) monotherapy in patients with HER2-negative metastatic breast cancer heavily pretreated with anthracycline and taxanes: a single-arm, phase II study
Authors: Jiang Hanfang , Li Huiping , Song Guohong , Di Lijun , Shao Bin , Yan Ying , Liu Xiaoran , Chen Yifei , Zhang Ruyan , Ran Ran , Liu Yaxin , Gui Xinyu , Wang Nan , Wang Huan 
Published: March 2023

Abstract
Purpose
To evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) in patients with human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) heavily pretreated with anthracycline and taxanes.

Methods
In this single-arm, phase II study, patients with HER2-negative MBC previously treated with anthracycline and taxanes as second- to fifth chemotherapy received PLD (Duomeisu®, generic doxorubicin hydrochloride liposome) 40 mg/m2 every 4 weeks until disease progression, unacceptable toxicity, or completion of six cycles. Primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival (OS), objective response rate (ORR), disease control rate (DCR), clinical benefit rate (CBR), and safety.

Results
Of 44 enrolled patients (median age, 53.5 years; range, 34–69), 41 and 36 were evaluable for safety and efficacy, respectively. In total, 59.1% (26/44) of patients had ≥ 3 metastatic sites, 86.4% (38/44) had visceral disease, and 63.6% (28/44) had liver metastases. Median PFS was 3.7 months (95% confidence interval [CI] 3.3–4.1) and median OS was 15.0 months (95% CI 12.1–17.9). ORR, DCR, and CBR were 16.7%, 63.9%, and 36.1%, respectively. The most common adverse events (AEs) were leukopenia (53.7%), fatigue (46.3%), and neutropenia (41.5%), with no grade 4/5 AEs. The most common grade 3 AEs were neutropenia (7.3%) and fatigue (4.9%). Patients experienced palmar-plantar-erythrodysesthesia (24.4%, 2.4% grade 3), stomatitis (19.5%, 7.3% grade 2), and alopecia (7.3%). One patient displayed a left ventricular ejection fraction decline of 11.4% from baseline after five cycles of PLD therapy.

Conclusion
PLD (Duomeisu®) 40 mg/m2 every 4 weeks was effective and well-tolerated in patients with HER2-negative MBC heavily pretreated with anthracycline and taxanes, revealing a potentially viable treatment option for this population.
Trial registration Chinese Clinical Trial Registry: ChiCTR1900022568.
Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists
Authors: Sars Carl , Sackey Helena , Frisell Jan , Dickman Paul W. , Karlsson Fredrik , Kindts Isabelle , Marta Gustavo Nader , Freitas-Junior Ruffo , Tvedskov Tove Filtenborg , Kassem Loay , Ali Ahmed S. , Ihalainen Hanna , Neron Mathias , Kontos Michalis , Kaidar-Person Orit , Meattini Icro , Francken Anne Brecht , van Duijnhoven Frederieke , Moberg Ingvild Ona , Marinko Tanja , Kollar Attila , Ahmed Mahbubl , Remoundos Dennis , Banks Jenny , Jagsi Reshma , Dossett Lesly A. , Lindqvist Ebba K. 
Published: March 2023

Abstract
Purpose
Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lacking.

Methods
We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors. The survey was constructed in REDCap and distributed between July 2021 and February 2022 through international collaborators in sixteen countries across four continents.

Results
A total of 419 responses were collected and analyzed. The majority of respondents were experienced and worked in a university hospital. Most agreed to recommend a tumor-free excision margin for benign tumors, increasing margins for borderline and malignant tumors. The multidisciplinary team meeting plays a major role in the treatment plan and follow-up. The vast majority did not consider axillary surgery. There were mixed opinions on adjuvant treatment, with a trend towards more liberal regiments in patients with locally advanced tumors. Most respondents preferred a five-year follow-up period for all phyllodes tumor types.

Conclusions
This study shows considerable variation in clinical practice managing phyllodes tumors. This suggests the potential for overtreatment of many patients and the need for education and further research targeting appropriate surgical margins, follow-up time and a multidisciplinary approach. There is a need to develop guidelines that recognize the heterogeneity of phyllodes tumors.
The influence of future weather pattern changes and projected sea-level rise on coastal flood impacts around the UK
Authors: Perks Rachel J. , Bernie Dan , Lowe Jason , Neal Robert 
Published: March 2023

AbstractWhen local extreme water levels surpass defences, the consequences can be devastating. We assess the importance of sea-level rise and future weather pattern changes on UK coastal flood impacts. Historical weather pattern classifications are matched with the observed skew surges and significant wave heights. Coastal-risk weather patterns are then defined as ≥ 1% of events in the distribution exceeding the local warning threshold. We combine this methodology with projections of sea-level rise and weather pattern frequency occurrences, to determine the relative importance of each on future coastal risk. A deep low-pressure system situated to the west of Ireland (WP29) has the highest probability (6.3%) of exceeding Newlyn’s present-day warning threshold; this is projected to increase under climate change to 46.2% by 2050 under RCP2.6. This work found that weather patterns associated with storm surges are increasing and decreasing in frequency; a synoptic situation causing windy conditions in the north of the UK (WP23) will increase by > 40% under RCP8.5 by the end of the century (2079–2090). When combining the impact of sea-level rise and changing frequency of weather patterns, this study found that sea-level rise dominates future coastal risk and is highly linked to the future emission scenarios. The need for successful adaptation, such as coastal defence improvements and early warning systems, will become even more important under the higher emission pathway. The most significant increases in coastal risk are found along the east coast, through the English Channel to the north Devon coastline.