bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subacute changes in brain functional network connectivity after nocturnal sodium oxybate intake are associated with anterior cingulate GABA
Authors: Bavato Francesco , Esposito Fabrizio , Dornbierer Dario A , Zölch Niklaus , Quednow Boris B , Staempfli Philipp , Landolt Hans-Peter , Seifritz Erich , Bosch Oliver G 
Published: March 2023

Abstract
Sodium oxybate (γ-hydroxybutyrate, GHB) is an endogenous GHB/GABAB receptor agonist, clinically used to promote slow-wave sleep and reduce next-day sleepiness in disorders such as narcolepsy and fibromyalgia. The neurobiological signature of these unique therapeutic effects remains elusive. Promising current neuropsychopharmacological approaches to understand the neural underpinnings of specific drug effects address cerebral resting-state functional connectivity (rsFC) patterns and neurometabolic alterations. Hence, we performed a placebo-controlled, double-blind, randomized, cross-over pharmacological magnetic resonance imaging study with a nocturnal administration of GHB, combined with magnetic resonance spectroscopy of GABA and glutamate in the anterior cingulate cortex (ACC). In sum, 16 healthy male volunteers received 50 mg/kg GHB p.o. or placebo at 02:30 a.m. to maximize deep sleep enhancement and multi-modal brain imaging was performed at 09:00 a.m. of the following morning. Independent component analysis of whole-brain rsFC revealed a significant increase of rsFC between the salience network (SN) and the right central executive network (rCEN) after GHB intake compared with placebo. This SN-rCEN coupling was significantly associated with changes in GABA levels in the ACC (pall &lt; 0.05). The observed neural pattern is compatible with a functional switch to a more extrinsic brain state, which may serve as a neurobiological signature of the wake-promoting effects of GHB.
Clinical outcomes of handmade polytetrafluoroethylene trileaflet-valved conduit used for pulmonary valve replacement
Authors: Chang Te-I , Hsu Kang-Hong , Hung Wei-Li , Yeh Shu-Jen , Chen Ming-Ren , Chien Yu-San , Hsu Ron-Bin , Wang Jou-Kou , Chang Ruey-Feng , Chang Chung-I 
Published: March 2023

Abstract

OBJECTIVES
To mitigate the shortage of homograft sources, the use of handmade trileaflet expanded polytetrafluoroethylene valves in pulmonary valve replacement has shown excellent results from multicentre studies conducted in Japan. However, world-wide data outside Japan are relatively insufficient. This study presents the long-term results of a single surgeon’s use of flipped-back trileaflet method in a 10-year case series.

METHODS
We have developed an efficient way to make a trileaflet-valved conduit utilizing flipped-back method for pulmonary valve replacement and have employed the technique since 2011. Retrospective data were studied between October 2010 and January 2020. Echocardiography, electrocardiogram, Pro-Brain Natriuretic Peptide and Magnetic Resonance Imaging data were analysed.

RESULTS
Fifty-five patients were reviewed and median follow-up duration was 2.9 years. The majority of diagnoses was Tetralogy of Fallot (n = 41), and these patients subsequently underwent secondary pulmonary valve replacement at a median age of 15.6 years. Survival was 92.7% with the longest follow-up period being 10 years. There was no need for reoperation, and freedom from reintervention was 98.0% at 10 years. There were 4 deaths (3 in-hospital and 1 outpatient). One patient eventually received transcatheter pulmonary valve implantation. Postoperative echocardiography showed mild or less pulmonary stenosis and pulmonary regurgitation degree in 92.2% and 92.0% of patients, respectively. Comparable magnetic resonance imaging data (n = 25) showed significant reduction in right ventricular volumes but not in ejection fractions.

CONCLUSIONS
Our series showed satisfactory long-term function of handmade flipped-back trileaflet-valved conduit used in our patients. The simple design is efficiently reproducible without complex fabrication process.
‘Democratic colonialism’, citizenship and the 1937 Godart mission to Indochina
Authors: Edwards M Kathryn 
Published: March 2023

Abstract
In 1937, Justin Godart was despatched by the Popular Front government to undertake a mission of inquiry in French India and Indochina. This article examines the objectives and repercussions of the Godart mission at a time of burgeoning Vietnamese nationalism and its repression by colonial authorities. It highlights the tensions between the Popular Front’s ‘democratic colonialism’—and the French left’s commitment to democratization more generally —and the demands of colonized subjects who were making claims to civil, social and political rights.
Cell type–specific interpretation of noncoding variants using deep learning–based methods
Authors: Sindeeva Maria , Chekanov Nikolay , Avetisian Manvel , Shashkova Tatiana I , Baranov Nikita , Malkin Elian , Lapin Alexander , Kardymon Olga , Fishman Veniamin 
Published: March 2023

Abstract
Interpretation of noncoding genomic variants is one of the most important challenges in human genetics. Machine learning methods have emerged recently as a powerful tool to solve this problem. State-of-the-art approaches allow prediction of transcriptional and epigenetic effects caused by noncoding mutations. However, these approaches require specific experimental data for training and cannot generalize across cell types where required features were not experimentally measured. We show here that available epigenetic characteristics of human cell types are extremely sparse, limiting those approaches that rely on specific epigenetic input. We propose a new neural network architecture, DeepCT, which can learn complex interconnections of epigenetic features and infer unmeasured data from any available input. Furthermore, we show that DeepCT can learn cell type–specific properties, build biologically meaningful vector representations of cell types, and utilize these representations to generate cell type–specific predictions of the effects of noncoding variations in the human genome.
Study on the effect of additives on microbial diversity, predicted functional profiles, and fermentation quality ofBroussonetia papyriferaandPennisetum sinesemixed ensilage in the karst region
Authors: Xu Duhan , Li Maoya , Wang Yuhan , Long Jianhua , Fan Xueying , Lei Yao , Li Ping , Cheng Qiming , Chen Yulian , Chen Chao 
Published: March 2023

AbstractIn this research, we evaluated the effect of exogenous lactic acid bacteria and Amomum villosum essential oil (AVEO) on the chemical composition, microbial community composition, microbial functional diversity, and fermentation quality of Broussonetia papyrifera (BP) and Pennisetum sinese (PS) mixed silages. The BP:PS mixing ratios were 100:0, 70:30, 50:50, 30:70, and 0:100. After 3 and 30 days of ensiling at 22°C–25°C, microbial diversity and function, and fermentation quality, were assessed. Increasing PS content resulted in decreased ammoniacal nitrogen and pH, increased water-soluble carbohydrate content, increased relative abundance of Lactococcus and Acinetobacter, and reduced relative abundance of Caproiciproducens and Pseudomonas. A 50:50 BP:PS ratio effectively improved the fermentation quality compared to anaerobic fermentation with BP or PS alone, while AVEO treatment further improved fermentation quality by increasing Lactococcus relative abundance. Moreover, as fermentation proceeded, ensiling enhanced the ‘Human diseases’, ‘Environmental information processing’, and ‘Cellular processes’ functions at the first level, as well as the ‘Two-component system’ and ‘ABC transporters’ functions at the third level. Different additives affected the fermentation of BP and PS mixed silage by regulating microbial community succession and metabolic pathways during ensiling.
TTV constraints on additional planets in the WD 1856+534 system
Authors: Kubiak Sarah , Vanderburg Andrew , Becker Juliette , Gary Bruce , Rappaport Saul A , Xu Siyi , de Beurs Zoe 
Published: March 2023

ABSTRACT
WD 1856+534 b (or WD 1856 b for short) is the first known transiting planet candidate around a white dwarf star. WD 1856 b is about the size of Jupiter, has a mass less than about 12 Jupiter masses, and orbits at a distance of about 2 per cent of an astronomical unit. The formation and migration history of this object is still a mystery. Here, we present constraints on the presence of long-period companions (where we explored eccentricity, inclination, mass, and period for the possible companion) in the WD 1856+534 planetary system from transit timing variations. We show that existing transit observations can rule out planets with orbital periods less than about 500 d. With additional transit observations over the next decade, it will be possible to test whether WD 1856 also hosts additional long-period planets that could have perturbed WD 1856 b into its current close-in orbit.
Saturation of the magnetorotational instability and the origin of magnetically elevated accretion discs
Authors: Begelman Mitchell C , Armitage Philip J 
Published: March 2023

ABSTRACT
We propose that the strength of angular momentum transport in accretion discs threaded by net vertical magnetic field is determined by a self-regulation mechanism: the magnetorotational instability (MRI) grows until its own turbulent resistivity damps the fastest growing mode on the scale of the disc thickness. Given weak assumptions as to the structure of MRI-derived turbulence, supported by prior simulation evidence, the proposed mechanism reproduces the known scaling of the viscous α-parameter, $\alpha \propto \beta _z^{-1/2}$. Here, $\beta _z = 8\pi p_{\rm g}/B_{z0}^2$ is the initial plasma β-parameter on the disc mid-plane, Bz0 is the net field, and pg is the mid-plane gas pressure. We generalize the argument to discs with strong suprathermal toroidal magnetic fields, where the MRI growth rate is modified from the weak-field limit. Additional sources of turbulence are required if such discs are to become magnetically elevated, with the increased scale heights near the mid-plane that are seen in simulations. We speculate that tearing modes, associated with current sheets broadened by the effective resistivity, are a possible source of enhanced turbulence in elevated discs.
Spatial curvature and thermodynamics
Authors: Banerjee Narayan , Mukherjee Purba , Pavón Diego 
Published: March 2023

ABSTRACTReasonable parametrizations of the current Hubble data set of the expansion rate of our homogeneous and isotropic universe, after suitable smoothing of these data, strongly suggest that the area of the apparent horizon increases irrespective of whether the spatial curvature of the metric is open, flat, or closed. Put in another way, any sign of the spatial curvature appears consistent with the second law of thermodynamics.
The RNA-binding protein MdHYL1 modulates cold tolerance and disease resistance in apple
Authors: Shen Xiaoxia , Song Yi , Ping Yikun , He Jieqiang , Xie Yinpeng , Ma Fengwang , Li Xuewei , Guan Qingmei 
Published: March 2023

Abstract
Apple (Malus domestica) trees often experience various abiotic and biotic stresses. However, due to the long juvenile period of apple and its high degree of genetic heterozygosity, only limited progress has been made in developing cold-hardy and disease-resistant cultivars through traditional approaches. Numerous studies reveal that biotechnology is a feasible approach to improve stress tolerance in woody perennial plants. HYPONASTIC LEAVES1 (HYL1), a double-stranded RNA-binding protein, is a key regulator involved in apple drought stress response. However, whether HYL1 participates in apple cold response and pathogen resistance remains unknown. In this study, we revealed that MdHYL1 plays a positive role in cold tolerance and pathogen resistance in apple. MdHYL1 acted upstream to positively regulate freezing tolerance and Alternaria alternata resistance by positively modulating transcripts of MdMYB88 and MdMYB124 in response to cold stress or A. alternata infection. In addition, MdHYL1 regulated the biogenesis of several miRNAs responsive to cold and A. alternata infection in apple. Furthermore, we identified Mdm-miRNA156 (Mdm-miR156) as a negative regulator of cold tolerance and Mdm-miRNA172 (Mdm-miR172) as a positive regulator of cold tolerance, and that Mdm-miRNA160 (Mdm-miR160) decreased plant resistance to infection by A. alternata. In summary, we highlight the molecular role of MdHYL1 regarding cold tolerance and A. alternata infection resistance, thereby providing candidate genes for breeding apple with freezing tolerance and A. alternata resistance using biotechnology.
A Not-so-Simple Rule for ‘I’
Authors: Ciecierski Tadeusz , Rudnicki Jakub 
Published: March 2023

Abstract
Maximilian de Gaynesford has argued against the standard view that the reference of the first-person pronoun ‘I’ is determined by a rule linking the referent to some feature of the context of use. In this paper, we argue that de Gaynesford's arguments are inconclusive. Our main aim, however, is to formulate a novel version of the reference rule for ‘I’. We argue that this version can deal with several problematic cases. Our strategy involves analysing the so-called agent of the context as the person responsible for a particular speech act. From this analysis, we exclude a particular class of uses of ‘I’, uses that we believe are best understood as demonstrative.
Beyond Rainmaking: Climate Engineering on the Nineteenth Century Great Plains
Authors: Suits Robert 
Published: March 2023

Abstract
Settler colonists in the nineteenth-century American West thought humans could engineer climate change. The supposed method varied: agriculturists and boosters argued that farming moderated climates, arboriculturists that forest belts humidified the air, and popular theorists that shooting the sky with artillery could shock rain out of it. This article shows that these theories gained credibility from the ways they mimicked the language and appearance of science and statistics. Climate counter-experts became famous because they could put on a performance of seeming scientific fluency. These techno-optimists produced theory after theory that remaking western environments to be more humid, green, and cultivable required the extension of American empire and ecologies, and the extirpation of Indigenous peoples and ecologies. Each theory fell in turn after material conditions of drought and catastrophe proved them wrong. But these ideas nevertheless survived into the climate politics of the present day.
The association between postvoid residual and response to standard therapy in male and female patients with non–muscle-invasive bladder cancer
Authors: Di Gianfrancesco Luca 
Published: March 2023

Abstract

Background
The urinary retention is recognized as a promoting factor for bladder cancer, but its role as prognostic factor of therapeutic response has not yet been widely considered. To correlate bladder outlet characteristics with short-term response to treatment in non–muscle-invasive bladder cancer.

Materials and methods
We carried out a case-control study on 600 consecutive patients with a first diagnosis of non–muscle-invasive bladder cancer, recruited at the first endoscopic follow-up visit after standard treatment: 200 patients were not tumor-free (cases) and 400 were tumor-free (controls). Patients were compared based on baseline and bladder-outlet characteristics ("functional parameters”: postvoid residual volume [PVR], International Prostatic Symptoms Score, perceived quality of bladder outlet). t Test, χ
2 test, receiver operating characteristic curves, logistic correlations, and multivariate analysis were applied.

Results
The cases had higher statistically significant PVR values compared with controls. We reported a linear correlation of no–tumor-free status with PVR (R
2 = 0.087, p < 0.005); the receiver operating characteristic curves revealed an area under the curve of 0.824 (95%confidence interval, 0.783–0.865; optimal PVR cutoff, 50 mL). In the multivariate analysis, age, American Society of Anesthesiologists score ≥2, risk category ≥intermediate, and all functional parameters represented independent factors for no–tumor-free status.

Conclusions
Urinary retention could represent a prognostic factor of treatment response, and its active treatment should be considered as an important therapeutic step into the clinical management of bladder cancer patients.
Hepatic C-X-C chemokine receptor type 6–expressing innate lymphocytes limit detrimental myeloid hyperactivation in acute liver injury
Authors: Heymann Felix , Mossanen Jana C. , Peiseler Moritz , Niemietz Patricia M. , Araujo David Bruna , Krenkel Oliver , Liepelt Anke , Batista Carneiro Matheus , Kohlhepp Marlene S. , Kubes Paul , Tacke Frank 
Published: March 2023

Background:
Acute liver failure (ALF) is characterized by rapid clinical deterioration and high mortality. Acetaminophen (APAP or paracetamol) overdose is a leading cause of ALF, resulting in hepatocellular necrosis with subsequent inflammation, inflicting further liver damage. Infiltrating myeloid cells are early drivers of liver inflammation. However, the role of the abundant population of liver-resident innate lymphocytes, which commonly express the chemokine receptor CXCR6, is incompletely understood in ALF.

Methods:
We investigated the role of CXCR6-expressing innate lymphocytes using the model of acute APAP toxicity in mice deficient in CXCR6 (Cxcr6

gfp/gfp
).

Results:
APAP-induced liver injury was strongly aggravated in Cxcr6

gfp/gfp
mice compared with wild-type counterparts. Immunophenotyping using flow cytometry revealed a reduction in liver CD4+T cells, natural killer (NK) cells, and most prominently, NKT cells, whereas CXCR6 was dispensable for CD8+ T-cell accumulation. CXCR6-deficient mice exhibited excessive neutrophil and inflammatory macrophage infiltration. Intravital microscopy revealed dense cellular clusters of neutrophils in necrotic liver tissue, with higher numbers of clustering neutrophils in Cxcr6

gfp/gfp
mice. Gene expression analysis linked hyperinflammation in CXCR6 deficiency to increased IL-17 signaling. Although reduced in overall numbers, CXCR6-deficient mice had a shift in NKT cell subsets with increased RORγt-expressing NKT17 cells as a likely source of IL-17. In patients with ALF, we found a prominent accumulation of IL-17–expressing cells. Accordingly, CXCR6-deficient mice lacking IL-17 (Cxcr6

gfp/gfp

x Il17

−/−
) had ameliorated liver damage and reduced inflammatory myeloid infiltrates.

Conclusions:
Our study identifies a crucial role of CXCR6-expressing liver innate lymphocytes as orchestrators in acute liver injury containing IL-17–mediated myeloid cell infiltration. Hence, strengthening the CXCR6-axis or downstream inhibition of IL-17 could yield novel therapeutics in ALF.
A 10-year Australian experience of rare intraabdominal venous thrombosis with comparison to deep vein thrombosis and pulmonary embolism
Authors: Oktaviana Jesica , Lui Brandon , Ho Prahlad , Lim Hui Y. 
Published: March 2023

Objective
Intra-abdominal venous thromboembolism is rare with heterogeneous management. We aim to evaluate these thrombosis and compare them to deep vein thrombosis and/or pulmonary embolism.

Method
A 10-year retrospective evaluation of consecutive venous thromboembolism presentations (January 2011–December 2020) at Northern Health, Australia, was conducted. A subanalysis of intraabdominal venous thrombosis involving splanchnic, renal and ovarian veins was performed.

Results
There were 3343 episodes including 113 cases of intraabdominal venous thrombosis (3.4%) – 99 splanchnic vein thrombosis, 10 renal vein thrombosis and 4 ovarian vein thrombosis. Of the splanchnic vein thrombosis presentations, 34 patients (35 cases) had known cirrhosis. Patients with cirrhosis were numerically less likely to be anticoagulated compared to noncirrhotic patients (21/35 vs. 47/64, P = 0.17). Noncirrhotic patients (n = 64) were more likely to have malignancy compared to those with deep vein thrombosis and/or pulmonary embolism (24/64 vs. 543/3230, P < 0.001), including 10 patients diagnosed at time of splanchnic vein thrombosis presentation. Cirrhotic patients reported more recurrent thrombosis/clot progression (6/34) compared to noncirrhotic patients (3/64) (15.6 vs. 2.3 events/100-person-years; hazard ratio 4.7 (95% confidence interval 1.2–18.9), P = 0.030) and other venous thromboembolism patients (2.6/100-person-years; hazard ratio 4.7, 95% confidence interval 2.1–10.7; P < 0.001) with comparable major bleeding rates. All renal vein thrombosis were provoked including five malignant-related cases while three ovarian vein thrombosis occurred postpartum. No recurrent thrombotic or bleeding complications were reported in renal vein thrombosis and ovarian vein thrombosis.

Conclusion
These rare intraabdominal venous thromboses are often provoked. Splanchnic vein thrombosis (SVT) patients with cirrhosis have a higher rate of thrombotic complications, while SVT without cirrhosis was associated with more malignancy. Given the concurrent comorbidities, careful assessment and individualized anticoagulation decision is needed.
Disrupted voxel-mirrored homotopic connectivity in congenital nystagmus using resting-state fMRI
Authors: Wen Zhi , Kang Yan , Zhang Yu , Yang Huaguang , Xie Baojun 
Published: March 2023

Objectives
Idiopathic congenital nystagmus (CN) is a rare eye disease that can cause early blindness (EB). CN deficits are observed most frequently with oculomotor dysfunction; however, it is still unclear what neuromechanics underly CN with EB. Based on that visual experience requires the functional integration of both hemispheres, we hypothesized that CN adolescents with EB might exhibit impaired interhemispheric synchrony. Our study aimed to investigate the interhemispheric functional connectivity alterations using voxel-mirrored homotopic connectivity (VMHC) and their relationships with clinical features in CN patients.

Materials and methods
This study included 21 patients with CN and EB, and 21 sighted controls (SC), who were matched for sex, age and educational level. The 3.0 T MRI scan and ocular examination were performed. The VMHC differences were examined between the two groups, and the relationships between mean VMHC values in altered brain regions and clinical variables in the CN group were evaluated by Pearson correlation analysis.

Results
Compared with the SC group, the CN had increased VMHC values in the bilateral cerebellum posterior and anterior lobes/cerebellar tonsil/declive/pyramis/culmen/pons, middle frontal gyri (BA 10) and frontal eye field/superior frontal gyri (BA 6 and BA 8). No particular areas of the brain had lower VMHC values. Furthermore, no correlation with the duration of disease or blindness could be demonstrated in CN.

Conclusion
Our results suggest the existence of interhemispheric connectivity changes and provide further evidence for the neurological basis of CN with EB.