bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alfabetización sanitaria y COVID-19 en países de ingreso bajo, medio y medio alto: revisión sistemática
Authors: Arenas-Monreal Luz , Galvan-Estrada Itxchel G. , Dorantes-Pacheco Leonel , Márquez-Serrano Margarita , Medrano-Vázquez Monserrat , Valdez-Santiago Rosario , Piña-Pozas Maricela 
Published: February 2023

Objetivo: analizar las publicaciones de Alfabetización Sanitaria (AS) en relación con la pandemia de la COVID-19 en países de ingreso bajo, medio y medio-alto. Métodos: se realizó una revisión sistemática de literatura publicada en las bases de datos de PubMed, Scopus, Portal BVS y Europe PMC, entre el 2019 y el 2021, siguiendo las guías de Cochrane y PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses), y se escribió de acuerdo con los elementos de informe preferidos para revisiones sistemáticas. La calidad metodológica se comprobó utilizando Mixed Methods Appraisal Tool (MMAT), para evaluar críticamente la calidad de los estudios incluidos. Resultados: se revisaron 1397 artículos y tras la aplicación de criterios de elegibilidad se seleccionaron 92 estudios para el análisis. Se identificaron tres temas principales: dificultades y obstáculos, experiencias efectuadas sobre AS durante la pandemia y desafíos. Los determinantes sociales de la salud como educación, género, territorio y nivel socioeconómico obstaculizan la AS, además, otra de las dificultades es la ausencia en diversos países de planes, programas y guías de comunicación en salud. La infodemia fue una dificultad y un desafío en esta pandemia. Uno de los desafíos para la AS es la inequidad y pobreza. De las experiencias se encontraron mediciones de la AS en la población en general, en estudiantes y profesionales de la salud, además acciones de comunicación en salud y difusión de información para la prevención de la diseminación de la COVID-19 y para contrarrestar la infodemia. Conclusiones: las condiciones de vida de la población, así como el contexto sociocultural, económico y político de los países incluidos en esta revisión sistemática, influyen de manera decisiva en la AS de las personas.
Does Tenecteplase Before Mechanical Thrombectomy Result in a Faster Revascularization as Compared to Alteplase? Observations From a Comprehensive Stroke Care Center in Southern India
Authors: Kuruttukulam Gigy , Sundar Kaushik , Bhirud Lomesh , Panwar Ajay , Alapatt Paul J 
Published: February 2023

Background The Indian data concerning the endovascular mechanical thrombectomy (MT) in acute ischemic strokes (AIS) with large vessel occlusion (LVO) is still scarce and evolving. Tenecteplase (TNK) has been recently approved for intravenous stroke thrombolysis prior to the MT. Methods This study is a single-center retrospective study. We performed data analysis of the AIS patients who consecutively presented during the study period with LVO and underwent thrombectomy. Procedural success was defined by the post-thrombectomy angiographic picture of grades 2b and 3 on modified Thrombolysis in Cerebral Infarction (mTICI) scale. Primary efficacy outcome was defined as an improvement of ≥4 points in National Institute of Health Stroke Scale (NIHSS) score at 24 h. Secondary efficacy outcome was based on modified Rankin Scale (mRS) score at 90 days. We also performed a comparative analysis of TNK and alteplase subgroups. Results Successful recanalization (mTICI 2b/3) was achieved in 65 (86.67%) patients. There was a significant mean difference between the NIHSS scores on admission and at 24 h ( P < .001). Likewise, mRS score at 3 months also showed a significant mean difference as compared to baseline ( P < .001). A faster recanalization was observed in those who were thrombolyzed with TNK, needed fewer number of passes, and if the procedure was performed under conscious sedation. Conclusion This study further strengthens the Indian data on efficacy and safety of MT in LVO ischemic strokes. Besides, whether the observation of TNK resulting in a faster revascularization is due to some factors unaccounted in our study, or an actual effect on thrombus due to a high fibrin specificity, needs to be tested further in larger randomized studies with matched sample sizes.
A prefix and attention map discrimination fusion guided attention for biomedical named entity recognition
Authors: Guan Zhengyi , Zhou Xiaobing 
Published: February 2023

AbstractBackgroundThe biomedical literature is growing rapidly, and it is increasingly important to extract meaningful information from the vast amount of literature. Biomedical named entity recognition (BioNER) is one of the key and fundamental tasks in biomedical text mining. It also acts as a primitive step for many downstream applications such as relation extraction and knowledge base completion. Therefore, the accurate identification of entities in biomedical literature has certain research value. However, this task is challenging due to the insufficiency of sequence labeling and the lack of large-scale labeled training data and domain knowledge.ResultsIn this paper, we use a novel word-pair classification method, design a simple attention mechanism and propose a novel architecture to solve the research difficulties of BioNER more efficiently without leveraging any external knowledge. Specifically, we break down the limitations of sequence labeling-based approaches by predicting the relationship between word pairs. Based on this, we enhance the pre-trained model BioBERT, through the proposed prefix and attention map dscrimination fusion guided attention and propose the E-BioBERT. Our proposed attention differentiates the distribution of different heads in different layers in the BioBERT, which enriches the diversity of self-attention. Our model is superior to state-of-the-art compared models on five available datasets: BC4CHEMD, BC2GM, BC5CDR-Disease, BC5CDR-Chem, and NCBI-Disease, achieving F1-score of 92.55%, 85.45%, 87.53%, 94.16% and 90.55%, respectively.ConclusionCompared with many previous various models, our method does not require additional training datasets, external knowledge, and complex training process. The experimental results on five BioNER benchmark datasets demonstrate that our model is better at mining semantic information, alleviating the problem of label inconsistency, and has higher entity recognition ability. More importantly, we analyze and demonstrate the effectiveness of our proposed attention.
Competing endogenous RNA network analysis of the molecular mechanisms of ischemic stroke
Authors: Chen Jian-Min , Li Xiao-Lu , Yang Ye  , Xu Sen-Ming , Chen Qing-Fa , Xu Jian-Wen 
Published: February 2023

AbstractBackgroundIschemic stroke (IS) is a serious neurological disease that largely results in long-term disability and death. Extensive evidence has indicated that the activation of inflammation and ferroptosis significantly contribute to the development of IS pathology. However, the underlying molecular mechanism remains unclear. In this study, we aimed to identify potential biomarkers associated with IS through the construction of a competing endogenous RNA (ceRNA) network and to investigate the possible inflammatory and ferroptosis-related molecular mechanisms.ResultsWe identified 178 differentially expressed target messenger RNAs (DETmRNAs) associated with IS. As revealed through enrichment analysis, the DEmRNAs were mainly enriched in the inflammatory signaling pathways and also related to ferroptosis mechanism. The CIBERSORT algorithm showed immune infiltration landscapes in which the naïve B cells, naïve T cells, and monocytes had statistically different numbers in the cerebral infarction group compared with the control group. A ceRNA network was constructed in this study involving 44 long non-coding RNAs (lncRNAs), 15 microRNAs (miRNAs), and 160 messenger RNAs (mRNAs). We used the receiver operating characteristic (ROC) analysis to identify three miRNAs (miR-103a-3p, miR-140-3p, and miR-17-5p), one mRNA (TLR4), and one lncRNA (NEAT1) as the potential key biomarkers of the ceRNA network. The key mRNA and lncRNA were shown to be highly related to the ferroptosis mechanism of IS. The expression of these key biomarkers was also further validated by a method of quantitative real-time polymerase chain reaction in SH-SY5Y cells, and the validated results were consistent with the findings predicted by bioinformatics.ConclusionOur results suggest that the ceRNA network may exert an important role in the inflammatory and ferroptosis molecular mechanisms of IS, providing new insight into therapeutic IS targets.
Efficacy and safety of low-dose rituximab as induction therapy for antineutrophil cytoplasmic antibody-associated vasculitis with renal involvement: a Chinese case series
Authors: Liu Lin , Lu Haitao , Zou Guming , Wang Haifeng , Li Jing , Yang Yue , Zhang Jian , Wang Xueling , Li Wenge , Zhuo Li 
Published: February 2023

Abstract
Background
Rituximab (RTX) is a standard therapy for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). However, the most frequently used dose may lead to severe adverse effects (SAEs). We explored the efficacy and safety of low-dose RTX in Chinese patients with AAV.

Methods
A total of 22 Chinese patients diagnosed with AAV with renal involvement, including 8 treated with low-dose RTX (400 mg of RTX total over 4 weeks) and 14 treated with cyclophosphamide (CYC), were evaluated. The baseline clinical and pathological data and laboratory parameters during follow-up at months 1, 3, 6, and 12 were collected retrospectively.

Results
The baseline data showed no significant differences between the two groups. The median peripheral CD19+ cell counts in the RTX group decreased from 315.0/μL to 1.5/μL at 2 weeks, and to 2.5/μL at 1 month after the first dose. The median SCr level decreased from 267.8 μmol/L before treatment to 151.45 μmol/L at 1 month, 132.75 μmol/L at 3 months, 123.2 μmol/L at 6 months, and 151.9 μmol/L at 12 months in RTX-treated patients. The improvements in renal function, proteinuria, and ANCA titre were not significantly different between the two groups. The SAE rate was significantly lower in the RTX group (one SAE of pneumonia) compared with the CYC group.

Conclusions
This is the first report that low-dose RTX could be effective for the treatment of Chinese patients with AAV with renal involvement.
Prediction of pre-eclampsia at St. Mary's hospital lacor, a low-resource setting in northern Uganda, a prospective cohort study
Authors: Awor Silvia , Abola Benard , Byanyima Rosemary , Orach Christopher Garimoi , Kiondo Paul , Kaye Dan Kabonge , Ogwal-Okeng Jasper , Nakimuli Annettee 
Published: February 2023

Abstract
Background
Pre-eclampsia is the second leading cause of maternal death in Uganda. However, mothers report to the hospitals late due to health care challenges. Therefore, we developed and validated the prediction models for prenatal screening for pre-eclampsia.

Methods
This was a prospective cohort study at St. Mary's hospital lacor in Gulu city. We included 1,004 pregnant mothers screened at 16–24 weeks (using maternal history, physical examination, uterine artery Doppler indices, and blood tests), followed up, and delivered. We built models in RStudio. Because the incidence of pre-eclampsia was low (4.3%), we generated synthetic balanced data using the ROSE (Random Over and under Sampling Examples) package in RStudio by over-sampling pre-eclampsia and under-sampling non-preeclampsia. As a result, we got 383 (48.8%) and 399 (51.2%) for pre-eclampsia and non-preeclampsia, respectively. Finally, we evaluated the actual model performance against the ROSE-derived synthetic dataset using K-fold cross-validation in RStudio.

Results
Maternal history of pre-eclampsia (adjusted odds ratio (aOR) = 32.75, 95% confidence intervals (CI) 6.59—182.05, p = 0.000), serum alkaline phosphatase(ALP) < 98 IU/L (aOR = 7.14, 95% CI 1.76—24.45, p = 0.003), diastolic hypertension ≥ 90 mmHg (aOR = 4.90, 95% CI 1.15—18.01, p = 0.022), bilateral end diastolic notch (aOR = 4.54, 95% CI 1.65—12.20, p = 0.003) and body mass index of ≥ 26.56 kg/m2 (aOR = 3.86, 95% CI 1.25—14.15, p = 0.027) were independent risk factors for pre-eclampsia. Maternal age ≥ 35 years (aOR = 3.88, 95% CI 0.94—15.44, p = 0.056), nulliparity (aOR = 4.25, 95% CI 1.08—20.18, p = 0.051) and white blood cell count ≥ 11,000 (aOR = 8.43, 95% CI 0.92—70.62, p = 0.050) may be risk factors for pre-eclampsia, and lymphocyte count of 800 – 4000 cells/microliter (aOR = 0.29, 95% CI 0.08—1.22, p = 0.074) may be protective against pre-eclampsia. A combination of all the above variables predicted pre-eclampsia with 77.0% accuracy, 80.4% sensitivity, 73.6% specificity, and 84.9% area under the curve (AUC).

Conclusion
The predictors of pre-eclampsia were maternal age ≥ 35 years, nulliparity, maternal history of pre-eclampsia, body mass index, diastolic pressure, white blood cell count, lymphocyte count, serum ALP and end-diastolic notch of the uterine arteries. This prediction model can predict pre-eclampsia in prenatal clinics with 77% accuracy.
Tumor necrosis factor-α-inducible protein 8-like protein 3 (TIPE3): a novel prognostic factor in colorectal cancer
Authors: Xu Yue , Zhu Yong , Xia Hengbo , Wang Yanan , Li Lin , Wan Hong , Zhang Shuping , Xu Aman , Wang Liecheng , Gong Jiao , Zhang Pingping 
Published: February 2023

Abstract
Background
To explore the correlation of tumor necrosis factor-α-induced protein 8-like protein 3 (TIPE3) expressions in colorectal cancer (CRC) with tumor-immune infiltration and patient prognosis.

Methods
Formalin-fixed paraffin-embedded tumor samples from CRC patients (n = 110) were used in this study. Immunohistochemistry staining of TIPE3 and three prognostic immune biomarkers (CD8, CD20, and CD66b) was conducted in the tumor tissues and adjacent normal tissues. A Cox regression analysis of univariate and multivariate variables was performed to assess the correlation between TIPE3 and patient prognosis.

Result
We found that TIPE3 was mainly expressed in the cytoplasm, with a small amount in the nucleus. The expression of TIPE3 in tumor tissues is significantly higher than in adjacent normal tissues, and it is significantly correlated with the survival rate of patients in tumor tissues (p = 0.0038) and adjacent normal tissues (p<0.0001). Patients with a high TIPE3 expression had a lower survival rate, while patients with a low TIPE3 expression had a higher survival rate. Univariate regression analysis showed that the TIPE3 expression in tumor tissues (p = 0.007), the TIPE3 expression in adjacent normal tissues (p<0.001), the number of CD8+ T cells in tumor tissues (p = 0.020), the number of CD20+ B cells in tumor tissues (p = 0.023), the number of CD20+ B cells in adjacent normal tissues (p = 0.023), the number of CD66b+ neutrophils in tumor tissues (p = 0.005), the number of CD66b+ neutrophils in adjacent normal tissues (p<0.001), lymphatic metastasis (p = 0.010), TNM stage (p = 0.013), and tumor grade (p = 0.027) were significantly correlated with overall survival (OS). These prognostic factors were then subjected to multivariate regression analysis, and the results showed that the expression of TIPE3, the number of CD8+ T cells, and the number of CD66b+ neutrophils were prognostic factors affecting the OS rate of CRC patients.

Conclusion
We found that the TIPE3 protein is upregulated in CRC cancer tissues and is correlated with survival rate.
Job burnout and its influencing factors in Chinese medical staffs under China’s prevention and control strategy for the COVID-19 pandemic
Authors: Peng Shuzhi , Zhang Juhua , Liu Xingyue , Pei Mengyun , Wang Tingting , Zhang Peng 
Published: February 2023

Abstract
Objective
This study aimed to investigate the influencing factors of burnout among grassroots medical staff in China so as to provide a reference for improving their physical, psychological, and social statuses under China's prevention and control strategy for the COVID-19 pandemic and ensuring the sustainable supply of high-quality medical resources.

Methods
This study was performed on medical staff in five primary hospitals in Jiangsu Province, China, from May 1, 2022, to June 1, 2022, using a general information questionnaire and Maslach Burnout Inventory Scale. SPSS 25.0 and Stata 15.0 were used for two-track data entry and analysis. The OLS regression model was established to analyze the influencing factors for the job burnout of health care personnel.

Results
Two hundred seventy valid questionnaires were analyzed. The total score of job burnout was (30.16 ± 10.99). The scores of emotional exhaustion, depersonalization, and self-achievement were (9.88 ± 3.839), (11.99 ± 5.68), and (8.29 ± 5.18), respectively. Feeling depressed and stressed after the pandemic, days working over the past week, and work hours per shift had a positive impact on the Maslach Burnout total score. Increased income and hours working every week had a negative impact on the Maslach Burnout total score. However, sex, age in years, degree, professional title, job category, workplace, marital status, years in practice, health status, active management of health, idea of resignation, and promotion after the pandemic did not affect the Maslach Burnout total score.

Conclusion
The job burnout of medical staff is affected by health conditions, working conditions, the psychological consequences of a pandemic, wages and marital status. Hospital managers should formulate incentive measures according to different psychological changes in medical staff to create a good medical working environment under the normalization of COVID-19 pandemic prevention and control.
Genomic features and its potential implication in bone oligometastatic NSCLC
Authors: Liao Rongxin , Yi Guangming , Shen Lu , Zhang Xiaoyue , Xu Zaicheng , Peng Yuan , Yang Zhenzhou 
Published: February 2023

AbstractObjectivesEmerging evidence have demonstrated that oligometastatic non-small cell lung cancer (NSCLC) can achieve clinical benefit from local consolidative therapy. Bone oligometastasis is common in advanced lung cancer, but little is known about its molecular features. The purpose of our study aimed to investigate the genomic landscape bone oligometastatic NSCLC.MethodsWe collected paired blood and tissue samples from 31 bone oligometastatic NSCLC patients to make a comprehensive analysis of mutations by performing next-generation sequencing.ResultsA total of 186 genomic mutations were detected from 105 distinct cancer-relevant genes, with a median number of 6 alterations per tumor. The most frequently mutated genes were EGFR (58%) and TP53 (55%), followed by KRAS (16%), CDKN2A (13%) and MET (13%). The signatures related to smoking, aging, homologous recombination deficiency and APOBEC were identified as the most important mutational processes in bone oligometastasis. The median tumor mutation burden was 4.4 mutations/Mb. Altogether, genetic alterations of bone oligometastasis are highly targetable that 74.19% of patients had at least one actionable alteration that was recommended for targeted therapy based on the OncoKB evidence. Of these patients, 16.13% had two actionable alterations that could potentially benefit from a different combination of targeted drugs to achieve better outcomes.ConclusionOur research comprehensively elucidates the genomic features of bone oligometastatic NSCLC patients, which may optimize individualized cancer treatment in the era of precision medicine.
The implementation of a community-centered first aid education program for older adults—community health workers perceived barriers
Authors: Yin Guo , Chen Linghui , Wu Yuanrong , Zhao Fei , Zhu Qian , Lin Siting 
Published: February 2023

Abstract
Background
Older adults are a high-risk group for accidental injuries, and strengthening training in first aid for older adults can improve their first aid capabilities and minimize their post-accident mortality. Community health workers are the greatest option to equip older adults with first aid instruction and training. However, the development of first aid education for the public by community health workers fails to take into account the elderly population. In view of this, this study aims to explore the barriers and challenges of first aid training for older adults from the perspective of community health workers and to provide a basis for better first-aid training for older adults in the community.

Methods
This study adopted a qualitative research design. A total of 18 community health workers were recruited from two community health service centers in Qujing and one community health service center in Guangzhou from May to July 2022 to participate in the study. Participants were interviewed face-to-face using semi-structured in-depth interviews. The interview data were analyzed using Krippendorff's thematic clustering technique.

Results
The results of the study identified community health workers' perceived challenges and barriers to providing first aid training to older adults in the community as older adults-level barriers, community health workers-level barriers, management systems–level barriers, and society-level barriers.

Conclusions
Community health workers are highly aware of multiple barriers and challenges in providing first aid training to community-based elderly populations. In particular, lack of professional training, heavy workloads, and limited resources and financial support. Therefore, supportive training, policies, and government funding are crucial for community health workers to conduct first aid training for older adults.
Intravenous methylprednisolone pulse therapy and the risk of in-hospital mortality among acute COVID-19 patients: Nationwide clinical cohort study
Authors: Moromizato Takuhiro , Sakaniwa Ryoto , Tokuda Yasuharu , Taniguchi Kiyosu , Shibuya Kenji 
Published: February 2023

AbstractBackgroundSteroids are widely used to modulate the inflammatory reactions associated with coronavirus disease 2019 (COVID-19); however, the optimal upper limit dose of steroid use for acute COVID-19 care remains unclear and currently available data may suffer from a time-dependent bias of no effectiveness or reversed causation given the desperate situation of treatment during this pandemic. Accordingly, the aim of this study was to elucidate the impact of intravenous pulse therapy with methylprednisolone (500 mg or greater per day) on the risk of in-hospital mortality among patients with COVID-19 by controlling for time-dependent bias.MethodsWe performed a prospective cohort study with 67,348 hospitalised acute COVID-19 patients at 438 hospitals during 2020–2021 in Japan. The impact of intravenous methylprednisolone pulse therapy on the risk of in-hospital mortality was examined based on hazard ratios (HRs) and 95% confidence intervals (95% CIs), with stratification according to the status of invasive mechanical ventilation (iMV). Time-dependent bias was controlled for in a marginal structural model analysis, with reference to patients without methylprednisolone therapy.ResultsDuring the study period, 2400 patients died. In-hospital mortality rates of iMV-free patients without or with methylprednisolone pulse therapy were 2.3% and 19.5%, and the corresponding values for iMV-receiving patients were 24.7% and 28.6%, respectively. The marginal structural model analysis showed that intravenous pulse therapy with methylprednisolone was associated with a lower risk of in-hospital mortality among patients receiving-iMV (HR 0.59; 95% CI 0.52–0.68). In contrast, pulse therapy with methylprednisolone increased the risk of in-hospital mortality among iMV-free patients (HR 3.38; 95% CI 3.02–3.79). The benefits of pulse therapy for iMV-receiving patients were greater than in those treated with intermediate/higher doses (40–250 mg intravenously) of methylprednisolone (HR 0.80; 95% CI 0.71–0.89).ConclusionThe results of our study suggest that intravenous methylprednisolone showed dose–response efficiencies, and pulse therapy may benefit critically ill patients with acute COVID-19, such as those requiring iMV.