bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avaliação de rotulagem nutricional e do teor proteico de barras de proteína
Authors: Pereira Micael Felipe da Silva , Benis Carina Moro , Weis Cláudia Moreira Santa Catharina , Soares Adriana Lourenço 
Published: January 2025

O consumo dos suplementos proteicos vem crescendo e as barras de proteína são preferidas devido sua conveniência, praticidade, sabor e custo acessível. O objetivo deste trabalho foi avaliar a rotulagem nutricional e determinar o teor proteico de barras de proteína disponíveis comercialmente. As amostras foram identificadas com letras para preservar a identidade, seus rótulos foram analisados quanto às exigências dos regulamentos técnicos da Agência Nacional de Vigilância Sanitária (ANVISA) e o teor de proteína foi quantificado pelo método de microKjeldahl. Na análise dos rótulos, das sete marcas, verificou-se que três (A, D, F) apresentaram duas não conformidades e uma (E) apresentou apenas uma não conformidade. O requisito com maior número de não conformidade foi a descrição da quantidade diária recomendada pelo fabricante, estando ausente em quatro marcar (A, D, E, F). Em relação ao teor de proteínas, todas as barras apresentaram valores menores daqueles declarado nos rótulos, sendo que em três delas a variação foi superior a 20% (A, B, F). Quanto a percentagem do valor diário recomendado para proteína, apenas uma marca (D) apresentou valor igual ao declarado no rótulo e nas mesmas três marcas (A, B, F) a variação foi superior a 20%. Todas as barras de proteína avaliadas apresentaram pelo menos uma inconsistência quanto aos requisitos e quanto ao teor de proteínas declarados em seus rótulos, demonstrando que estes suplementos alimentares não estão sendo comercializados de acordo com as exigências da legislação comprometendo a qualidade e saúde dos consumidores.
Exploring the pharmacological potential of Macrobrachium acanthurus hemocyanin: preliminary biological activity studies
Authors: Ramos Lierge , Souza Claudemir de Oliveira , Sebastião Isis , Vilanculo Edson Miguel , Filho Norival Alves Santos , Santiago Patrícia Soares 
Published: January 2025

Hemocyanin (Hc) is a copper-containing hemoprotein found in the hemolymph of invertebrates such as mollusks and arthropods. It plays essential roles in oxygen transport, immune defense, and molting processes. Due to their antiviral, antimicrobial, and phenoloxidase (PO) activities, Hcs hold significant potential in biotechnology. This study aims to obtain the Hc from the shrimp Macrobrachium acanthurus and perform preliminary biological activity tests (PO and antimicrobial activity) of this Hc. The results will serve as a basis for future structural and biological investigations of this unique protein. HcMac was purified using ultracentrifugation and size exclusion liquid chromatography (SEC). PO activity was induced by the surfactant SDS in the presence of dopamine hydrochloride, monitored by optical absorption at 475 nm using a spectrophotometer. Tests were performed to evaluate the inhibitory activity against Candida neoformans, Candida albicans and some fish pathogens. The results demonstrated that the surfactant SDS induced PO activity, with optimal formation observed at an SDS concentration of 1.0 mmol L-1. However, HcMac did not exhibit antimicrobial activity in the tests performed. Despite this, we cannot rule out the hypothesis that this Hc has biological activity and an immunological role, since it showed PO activity.
Trastornos mentales en estudiantes de octavo semestre de la carrera de medicina, previo al ingreso del internado
Authors: Bencomo María Atocha Valdez , Barrera Elissa Chávez 
Published: January 2025

Introducción. En los espacios universitarios la inestabilidad emocional en los jovenes se vuelve un problema en el que todos los aspectos ambientales cuentan y dan pie a la aparición de rasgos de riesgo en la salud emocional de los alumnos. Objetivo. Identificar los trastornos mentales y nivel de estres en estudiantes de octavo semestre de la carrera de medicina de la UAGro., previo al ingreso del Internado. Material y método. El estudio tipo transversal y corte descriptivo. Población, estudiantes de octavo, generación 2019-2022. Instrumentos para recoleccion de información: Inventario de Sintomas SCL -90-R, Test FH Machover y Estres. Resultados. 241 estudiantes de octavo semestre de medicina, 40.24% hombres (n = 97) y 59.75% mujeres (n = 144). Hallazgos de 97 hombres, 11 reflejan TOC, Sensitividad interpersonal 6 hombres y 5 mujeres; Depresion 6 mujeres y 2 hombres; Ansiedad fóbica, 11 hombres y 17 mujeres; Paranoia 9 hombres y 2 mujeres; Psicoticismo 4 hombres y 6 mujeres. La prevalencia del estres, de 144 mujeres, 47 de ellas presentaron estres leve, y de los 97 hombres, 41 de ellos. Discusión. Los participantes del estudio, 22 (15.2%), son mujeres, y 23 (23.7%), hombres, obtuvieron un puntaje en el SCL-90 igual o mayor a 63. Destacando, que (18.7%) de estudiantes cursa con algun trastorno mental emocional de alta severidad. Conclusión. Imporotante identificar los trastornos emocionales desde primer semestre de formación academica, para atenderlos de inmediato antes de iniciar el internado rotatorio de pregado.
LEGAL MECHANISMS FOR CONSUMER PROTECTION UNDER ALGERIAN E-COMMERCE LAW
Authors: Zahia Kettab 
Published: January 2025

Purpose: This study aims to clarify the consumer's essential need for protection under Legal Perspective No. 18/05 and to reveal the extent of this protection throughout all stages of contracting.

Theoretical Framework: Despite the advantages offered by electronic marketing, the electronic environment is rife with risks that impact all elements of the relationship involving the consumer, who is considered the most critical and final link in the product cycle aimed at fulfilling its consumer purpose and meeting desires. Given the consumer's lack of information culture in the digital environment, the Algerian legislator, through Law No. 18/05, sought to protect the consumer during the stages of electronic contracting.

Methods: Highlighting the key provisions, rules, and articles introduced by the Algerian E-Commerce Law No. 18/05 through comprehensive analysis to emphasize the effectiveness of mechanisms for protecting the digital consumer.

Results and Discussion: The distinguishing feature of these transactions is that they take place in the virtual world, remotely, using the latest electronic communication tools. This exposes consumers to various types of fraud, deception, and violations, reflecting the darker side of electronic commercial transactions and making the consumer the primary victim. This prompted the Algerian legislator to adopt E-Commerce Law No. 05/18, dated May 10, 2018, by establishing legal mechanisms to protect the electronic consumer throughout the various stages of contractual operations.

Abstract: The revised legal framework represents a proactive step by the Algerian state to enhance the e-commerce sector by ensuring legal protection for consumers at all stages of contractual operations. Law No. 18-05 aims to demonstrate the extent to which the Algerian legislator has moved beyond traditional consumer protection frameworks, keeping pace with developments in commerce within the digital environment.

Originality/Value: The value of this research lies in the Algerian E-Commerce Law No. 18/05, which was issued to protect consumers in the digital environment.
Design and Implementation of Remote Update of RF Devices in Cloud-Based Smart Home Systems
Authors: Yılmaz Ekrem , Çelik Yüksel 
Published: January 2025

One of the most commonly used methods for accessing sensors and control points in smart home systems is communication via Radio Frequency (RF) waves. Even in newly constructed buildings, the most suitable method is to mount RF sensors and controllers. With current developments in cloud-based smart home and intercom systems, the software of the systems is also updated via an update server. But some updates may also be needed in RF sensors and controllers that are part of the system. Due to their cheap and simple structures, these devices developed with embedded software usually need to be removed from their places or reprogrammed with special devices by physical contact in order to update their software. But RF devices are often not easy to access. They are usually hidden in places such as behind sockets or junction boxes. In order to update their program remotely without removing them, a protocol has been developed between RF modules and in-apartment monitors/gateways and appropriate software has been written.
Demensia
Authors: Haiga Yuri , Yulson  , Sari Chaniago Reno 
Published: January 2025

Latar Belakang: Demensia adalah sindrom penurunan fungsi intelektual yang progresif, ditandai dengan gangguan kognitif dan fungsional yang memengaruhi aktivitas sehari-hari, fungsi sosial, dan profesional. Kondisi ini dapat disebabkan oleh berbagai penyakit degeneratif otak seperti demensia Alzheimer, demensia vaskular, demensia frontotemporal, dan demensia badan Lewy. Tujuan: Makalah ini bertujuan memberikan tinjauan komprehensif mengenai demensia, mencakup definisi, klasifikasi, patofisiologi, faktor risiko, kriteria diagnosis, serta tatalaksana yang tersedia. Metode: Makalah ini disusun melalui tinjauan pustaka dari berbagai sumber ilmiah yang membahas mekanisme fisiologis neuron, patofisiologi demensia, dan pendekatan klinis dalam diagnosis serta penatalaksanaannya. Hasil: Demensia melibatkan kerusakan neuron yang signifikan, ditandai dengan akumulasi protein abnormal seperti beta-amiloid dan tau pada Alzheimer, serta gangguan vaskular pada demensia vaskular. Diagnosis memerlukan evaluasi klinis menyeluruh berdasarkan kriteria DSM-5 dan MMSE. Tatalaksana meliputi terapi farmakologis seperti penghambat kolinesterase (donepezil, galantamine, rivastigmine) dan terapi non-farmakologis seperti stimulasi kognitif, terapi okupasi, dan dukungan bagi keluarga serta pengasuh. Kesimpulan: Demensia adalah kondisi kronis yang memerlukan pendekatan multidisiplin dalam diagnosis dan penatalaksanaan. Edukasi publik tentang faktor risiko dan upaya pencegahan melalui gaya hidup sehat sangat penting untuk mengurangi dampak penyakit ini.
Pelatihan Kompetensi Jaringan Komputer untuk Membekali Ramaja Karang Taruna dalam Menghadapi Dunia Kerja
Authors: Hiswara Abrar , Dian Hartanti  , Achmad Noe’man  
Published: January 2025

Kompetensi dibidang Jaringan komputer menjadi tren saat ini karena dibutuhkan hampir di segala bidang, sehingga menguasai jaringan komputer menjadi nilai tambah serta daya saing dalam dunia kerja. Pelaksanaan pengabdian kepada masyarakat ini bertujuan untuk membekali remaja karang taruna Bekasi tentang kompetensi jaringan komputer guna mempersiapkan diri dalam menghadapi persaingan didunia kerja., kegiatan pelatihan ini dilaksanakan di wilayah Chandra Baru selama tiga hari dengan jumlah peserta sebanyak dua puluh orang. Pelaksanaan kegiatan pelatihan ini menggunakan beberapa metode yaitu penyampaian paparan materi tentang konsep jaringan komputer, dan praktek. Sebelum dan sesudah kegiatan dilaksanakan tes dengan mengerjakan beberapa soal dan tes latihan guna mengetahui seberapa besar peningkatan pemahaman peserta latihan . Hasil dari pelaksanaan pengabdian masyarakat ini adalah adanya peningkatan kemampuan peserta sebesar 76,% baik secara teori dan praktek. Dengan adaanya pelatihan ini diharapkan peserta pelatihan mendapatkan skill keahlian yang nantinya akan bisa digunakan untuk memberikan bekal untuk mencari pekerjaan maupun memperoleh peluang bisnis serta membuka lapangan kerja, sehingga dapat meningkatkan taraf hidup.

Kata Kunci: Pelatihan, Jaringan Komputer, Karang Taruna
حماية حق الحياة دراسة حقوقيِّة في الفكر المقاصدي
Authors: مفتاح أغنيه محمد  
Published: January 2025

خلق الله عز وجل الإنسان وكرمه ، ووضع له أسس وقواعد تنظم حياته ، وجاءت الشريعة الإسلامية الغراء للحفاظ على كيان الإنسان وحمايته بإعتباره خليفة الله في الأرض وهو الذي يعمرها ، وبيني حضارتها ، وهو ما يستلزم توفير كافة وسائل الحياة وضمان استمرارها وأولها (حفظ النفس) حيث أعتبر من يزهق روح إنسان بغير حق كأنما قتل الناس جميعا ، وهو ما يستوجب علينا أن نعتقد إعتقاداً جازما أن الله تعالى ما أمر عباده بأمر إلا وفيه مصلحتهم ، وما تجاهم عن فعل شيء إلا وكانت فيه مفسدة أو ضرر، وهذا من أعظم مقاصد الشريعة ، فلا جدال إذن في أن حقوق الإنسان ليست نتاج الحضارة الغربية بل أن حل المبادئ والقيم الإنسانية التي تبناها الغرب الآن تحد جذورها في الشريعة الإسلامية حيث سوى الإسلام بين جميع الناس رغم إختلاف أجناسهم وطوائفهم ، وكفل لهم الحماية الفعالة من خلال تحريم القتل مطلقاً وشدد العقوبة عليه إلا بالحق إذ تعني جريمة القتل الواحدة في الشريعة الإسلامية قتل أفراد المجتمع بأسرة فالشريعة قد أضفت على حق الحياة هالة من القداسة ، لأن الإنسان لم يخلق عبثاً ، فحياة الإنسان واحدة مما يحتم كفالتها والحفاظ عليها ، وتحقيق وظيفة الإستخلاف في الأرض .
إن كل الدساتير بما فيها الدستور الليبي 1951 ، والإعلان الدستوري المؤقت 1969 والإعلان الدستوري المؤقت 2011 نصت على حماية الحقوق والحريات حيث تضمن الدولة عدم إنتهاك حرية الإنسان أو المساس بكرامته ولما كانت الحماية الجنائية للحقوق والحريات وفي مقدمتها (حق الحياة) تتم من خلال التحريم والعقاب وعن طريق إعتماد الدولة للإجراءات الجنائية التي تمكن من الإقتصاص من المعتدي فإن هذا قد يؤدي إلى التضحية بحقوق الأفراد الذين حرم القانون أفعالهم ومنعاً للظلم والتعسف قرر الدستور حماية حقوق المتهم أيضاً قبل المحاكمة وأثناءها وبعدها كي لا يكون ضحية تعسف في إستعمال السلطة للحق المحول لها ، فكان من اللازم في هذا البحث التعرض للعلاقة بين الدستور وقانون العقوبات وبينه وبين قانون الإجراءات الجنائية ، وبيان الكيفية التي يحمى بها قانون العقوبات حق الحياة .
وستحاول من خلال هذا البحث بيان سبل حماية هذا الحق في الشريعة الإسلامية كدراسة مقاصدية قانونية وبيان حماية هذا الحق في القانون الوضعي، وتحديد مدى توافقهما حول هذا الحق، ومدى إختلافهما حوله مع إبراز الدور المقاصدي للشريعة الإسلامية في تحريم كل ما يلحق ضررا بالنفس البشرية التي أودعها الله في جسد الإنسان وليست ملكاً له ، إن غياب الوازع الديني هو ما ساهم في إنتشار القتل في مجتمعنا الليبي في السنوات الأخيرة ، وخاصة أعمال الإغتيال، والتصفية والإعدام خارج القانون و غيرها من الجرائم الأخرى، ولأن الحق في الحياة حق مقدس فلا يجوز المساس به مطلقاً مما يستدعي حمايته بشتى السبل وتحريم كل إعتداء عليه ، ولأن هذا الحق ليس على إطلاقه بل هو مفيد فلا بد من التعرض للإستثناء اتر القيود الواردة عليه سواء في الشريعة الإسلامية أو القانون الوضعي.
PHÂN TÍCH Ý NGHĨA CỦA CÁC TỪ NỐI: VÌ - BỞI – DO - TẠI – NHỜ
Authors: Trần Thị Lệ Dung , Nguyễn Thị Mai Hương  , Nguyễn Thanh Bình, Hoàng Thúy Nga  
Published: January 2025

Các hư từ hay từ nối, như vì, bởi, do, tại , nhờ xưa nay chỉ được giải thích ý nghĩa ngữ pháp rất khái quát giống nhau là chỉ nguyên nhân (hoặc lí do), mà chưa được chỉ ra ý nghĩa riêng biệt của từng từ.Bài viết áp dụng phương pháp phân tích thành tố dựa theo các tham tố ( hay tham thể) trong cấu trúc nghĩa của vị từ, đồng thời dựa vào cách tìm các ngữ cảnh trống, tức ngữ cảnh có giá trị khu biệt nghĩa của từng từ trong một dãy từ đồng nghĩa, để phát hiện những nét nghĩa khu biệt của mỗi hư từ hay từ nối đồng nghĩa này trong dãy gồm 5 từ nối đồng nghĩa đã nêu.
Antibody Drugs in Alzheimer’s Disease
Authors: Zhou Jinghan 
Published: January 2025

Alzheimer's disease is one of the important causes of Alzheimer's disease. The prevalence rate has been increasing in recent years, which is a hot issue for the medical community. In view of the pathogenesis of Alzheimer's disease is still not exactly diagnosed, the research and development of related drugs is not particularly ideal. Existing drugs mostly stay in symptomatic treatment. However, in recent years, the medical community has gradually turned to causative treatment. Among them, disease-modifying therapy (DMT) is the most frequently studied drug at present, accounting for 82.5% of the total drugs under consideration. Among the DMT-class drugs, 16 (equivalent to 15.4%) are specifically designed as anti-amyloid beta (Aβ) monoclonal antibodies (Mabs), while 11 (accounting for 10.6%) target tau proteins with monoclonal antibody technology. Through reviewing past literature and comparing data, this paper takes Aducanumab, Lecanemab, and CCTM2 as examples to explore the therapeutic principles and make a summary.
Clinical application status and development of TNBC (BC) monoclonal antibody
Authors: Ding Zian 
Published: January 2025

A particular subtype of breast cancer known as triple-negative breast cancer (TNBC) is distinguished by the lack of ER, PR, and HER2 expression, culminating in HER2-targeted therapy with a poor prognosis and inadequate conventional hormone therapy. With the growing comprehension of the biological traits of TNBC in recent years, treatment strategies have gradually developed, particularly the use of mAb medications, which has renewed optimism for the treatment of TNBC. Because of its high specificity and targeting, mAb drugs have shown remarkable efficacy and potential in cancer treatment. An extensive examination of the clinical usage of mAb medications in the treatment of TNBC is given in this review. summarizing clinical trial data on key drugs such as PD-1/PD-L1 and TROP-2-targeted drugs, demonstrating the significant effect of these drugs in prolonging PFS and OS in patients. At the same time, new therapeutic targets besides PD-1 and TROP-2 are discussed, as well as the potential advantages of combination therapy strategies. The clinical application of mAb medications in TNBC is thoroughly examined in this study., summarizing clinical trial data on key drugs such as PD-1/PD-L1 and TROP-2-targeted drugs, demonstrating the significant effect of these drugs in prolonging PFS and OS in patients. At the same time, new therapeutic targets besides PD-1 and TROP-2 are discussed, as well as the potential advantages of combination therapy strategies.
The Examination of the Effects of FDI on International Trade of the ASEAN Economic Community
Authors: Ky Sereyvath 
Published: January 2025

The examination of the effects of foreign direct investment on international trade and trade balance was conducted within the member states of the ASEAN Economic Community, which include Brunei, Cambodia, Indonesia, Laos, Malaysia, Myanmar, the Philippines, Singapore, Thailand, and Vietnam, covering the period from 2001 to 2022. To derive empirical insights, various static panel data models were employed, specifically the Pooled Ordinary Least Squares, Fixed Effect, and Random Effect models. In addition to FDI, the analysis incorporated three key variables: the real GDP growth rate, inflation rate, and foreign exchange rate, to evaluate their influence on international trade. The findings of this research indicate a positive correlation between net FDI inflows and trade levels, suggesting that increased FDI contributes to enhanced trade activity. Furthermore, the results emphasize that a rise in the real GDP growth rate and a depreciation of the exchange rate can foster a favorable trade balance, while an increase in the inflation rate tends to have a detrimental effect. Consistency across all panel data models was observed, with the Hausman test indicating that the Random Effect model is the most suitable for this analysis.
ESTUDO DO EFEITO TÉRMICO DE ALÍVIO DE TENSÃO NA ZONA TERMICAMENTE AFETADA - ZTA
Authors: França Edilon de Oliveira , Reis Roger Esteves de Almeida dos 
Published: January 2025

Neste estudo o objetivo foi analisar os efeitos causados pelo tratamento térmico de alívio de tensão, utilizando-se o processo de soldagem com metal inert gas (MIG) automática, uma fonte marca Lincoln electric modelo Power wave S350, com arame sólido 1,2 milímetros ER70S6, chapa de aço ASTM A36. Foi realizado um cordão de solda de revestimento no centro de cada chapa. Após o processo de soldagem, as chapas foram cortadas com auxílio da cortadeira metalográfica marca teclago modelo CM80 e retirada um pedaço quinze milímetros de largura, totalizando três amostras. Cada amostra foi identificada numericamente: amostra 1 sem tratamento de alívio de tensão; amostra 2 com alívio de tensão de 450°C e amostra 3 com alívio de tensão 650°C. Foram realizadas as medições de dureza no perfil do cordão de solda. Conclui-se que as amostras com tratamento térmico de 450°C não apresentou variação na dureza, a amostra de 650°C apresentou 6% na ZTA e 8% na solda.
A evolução da moda feminina do século XX através de um menu degustação
Authors: Francio Gabriela 
Published: January 2025

O interesse deste estudo é aproximar a gastronomia e a moda pela vertente da estética. A convergência destes assuntos foi explorada em um Trabalho de Conclusão do Curso de Gastronomia apresentado em um jantar – que dá origem a esse artigo -, onde desenvolveu-se um menu degustação de dez etapas inspirado na evolução da indumentária feminina do século XX. A principal metodologia utilizada foi a pesquisa bibliográfica, focada em constatar as características essenciais da indumentária feminina do período. O menu, desenvolvido intuitivamente, foi construído com ingredientes, elementos e conceitos usados para representar a moda e as sociedades das décadas de 1910 até aos anos 2000. As preparações abordaram técnicas básicas de gastronomia, confeitaria e panificação, além de apresentarem influências da cozinha internacional e brasileira, estudadas no decorrer das disciplinas práticas da graduação em Gastronomia.
Fatores associados à transmissão vertical de sífilis durante o período gravídico
Authors: Raulino Júlia Maria de Holanda , Lima Lucas Ferreira de , Soares Carolina Dá Rós , Duarte Francisco Gildo da Silva , Candido Stephany Costa Novo , Damasceno Janeide Lima Januário de Oliveira , Silva Juliana Santos da , Barbosa Christian Fonseca da Matta , Nascimento Maryane Lira , Santos Elaine Dias dos , Souza Maria Fernanda da Silva , Coelho Willian Lucas da Silva , Liberato Liciane Peixoto Costa , Silva Wicla Liberato da , Gomes Patrick Gouvea 
Published: January 2025

Este artigo tem por objetivo descrever os principais fatores de risco associados à transmissão vertical da sífilis durante a gestação. Trata-se de uma revisão integrativa da literatura, realizada nos materiais indexados na Biblioteca Virtual em Saúde (BVS): Medical Literature Analysis and Retrieval System Online (MEDLINE), a Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS) e a Base de Dados de Enfermagem. Foram utilizados os Descritores em Ciências da Saúde (DeCS) em cruzamento com o operador booleano AND, da seguinte forma: “Fatores de Risco” AND “Sífilis Congênita” AND “Gravidez”. Após a aplicação dos critérios de elegibilidade foram selecionados 7 (sete) estudos para compor essa revisão. Evidenciou-se que entre os fatores predisponentes para a transmissão vertical de sífilis no período gravídico destacam-se o baixo nível educacional materno, a ausência de renda, a faixa etária e a utilização de substâncias psicoativas. Além disso, a qualidade insuficiente dos serviços pré-natais ofertados e o tratamento inadequado foram associados a um risco aumentado para o desenvolvimento da condição. Portanto, é fundamental implementar medidas que amenizem os índices de transmissão vertical, por meio de protocolos e fluxogramas que auxiliem na mensuração dos riscos para a sífilis e no manejo adequado da doença, com atenção especial às gestantes em situação de vulnerabilidade socioeconômica.