bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medical Tourists’ Satisfaction and Decision-Making Factors with a focus on the Czech Republic
Authors: Hilšerová Monika 
Published: January 2023

Abstract
Medical tourism in the Czech Republic is a relatively new phenomenon, so far, no research has been conducted in this area to collect relevant data. This research aims to analyse and evaluate the experience of medical tourists and find out what is important and what influences them in choosing a destination where they will undergo the selected procedure. Based on qualitative research, which was conducted in the form of interviews with medical tourists who underwent medical intervention in the Czech Republic, the problems faced by medical tourists, and factors influencing their decision-making processes were identified. Finally, suggestions for improvement were found. The research focused on the areas of communication, behaviour, decision-making processes, and factors that lead to patient satisfaction. The results are important not only for the healthcare facilities themselves but also for the creation of an adequate marketing strategy, as it was found that the most important tool in the decision-making process is the word of mouth. It was found that medical tourists choose the country mostly based on the recommendation of family or friends, mostly those who have already undergone medical treatment in that country. Therefore, it is important that patients leave satisfied so that they can continue to recommend going for treatment abroad or particularly in the Czech Republic.
Government Communication Model in Strengthening Village Institutions in Bertah Village, North Sumatra
Authors: Simbolon Besti Rohana , Panjaitan Doli Tua Mulia Raja , Pardede Piki Darma Kristian 
Published: January 2023

Based on Government Regulation Number 8 of 2016 concerning the Second Amendment to Government Regulation Number 60 of 2014 concerning Village Funds from the State Budget (APBN), village funds must be managed in an orderly, obedient, efficient, economical, effective, transparent and responsible manner by paying attention to the sense of justice and propriety and prioritizing the interests of the local community. Therefore, it is important to strengthen village institutions and village officials, so that they are qualified and empowered to carry out development. Indonesia has a total of 83,820 villages which need to be assisted so that the disbursed village funds are not wasted. This study uses a qualitative grounded theory approach by observing, interviewing 30 informants and analyzing village documents. The results of the study found that the human resource factor of the village head as a communicator, was more trusted by village institutions and the community because of his open, democratic communication style, willingness to accept suggestions/opinions and empathy according to the equalitarian style and the relinquishing style of communication. The government communication model in strengthening village institutions is a mentoring model where communication starts from regency and district. However, the strengthening has not been seen optimally because of the high dependence of village institutions and village officials on village heads and village assistants so that they are less independent. The use of messages is more face-to-face, using messages and WhatsApp with information functions that are more persuasive and educative.
The Influence of Organizational Communication in Improving Safety Culture in PT. XYZ
Authors: Poernomo Marlinda Irwanti , P Bambang Sulistyo , Sufa Siska Armawati 
Published: January 2023

It is expected that an organization will conduct a communication process in building a culture. The management of a company presents some policies and responsibilities through verbal and non-verbal messages continuously. It aims to shape a safety culture behaviour for the organization members of the company themselves. Research of the internal and external organizational communication influences the effort to improve Safety Culture through conceptual system or communication model. In addition, it also aims to improve the influence of risk and K3 communication including in the implementation of Safety Culture in PT. XYZ’s work environment. This study used quantitative method in order to easily understand communication process in internal and external organizational communication. There are 162 respondents used as sample in this research. The data sampling technique uses Probability Sampling method with Proportionate Stratified Random Sampling. The analysis method that was used first for linear regression analysis was normality test. Then, the researchers conducted a validity and reliability test. The hypothesis test used significance test simultaneously and partial significance test. The research data was analysed through the SPSS 24 software. This test was conducted by seeing the value of F that was present in ANOVA table, significance level that was used was 0,05. Climate and satisfactory in communication developed a measurement in safety culture comprehensively that included safety culture instruments that was categorized into independent variables (X). It included safety culture indicators, safety culture climate, safety management system or situational, safety behaviour, and organizational communication.
The Mediatization and Culture Of The Korean Wave Phenomenon Among Malay Female Youth
Authors: Hisham Nurul Akqmie Badrul , Ahmad Abdul Latiff , Kee Chang Peng 
Published: January 2023

The development of media technology became a key element in constructing social realities. This study analyses the process of mediatization in contemporary youth culture and how social media has played a role in creating the mediated world. Aiming to explore the mediated world of Korean Wave female fans in Malaysia using the perspective mediatization and culture. This study was conducted using qualitative research and a netnography was conducted due to the movement control orders or locked downs that took place in many countries due to the Covid-19 pandemic. The study was conducted on events that took place on the Internet. This study shows social media as a catalyst in connecting fans with the social phenomenon and it has allowed fans to create their own mediated world and online community. The mediazation process bring fans and celebrities closer to each other with information on the Korean Wave obtained without interruption and filtering. Social media had led to negotiation creations of social reality, the empowerment of groups involved and these groups participation in the evolution of the Korean Wave becomes an essential part of the phenomenon.
الملاءمة المكانية للعوامل الطبيعية المؤثرة على استعمالات الأرض الزراعية في ناحية بعشيقة
Authors: Abdulkareem Yousafani Bashar Farooq 
Published: January 2023

تعد العوامل الطبيعية من أهم الضوابط التي تتحكم وتؤثر على انتاج المحاصيل الزراعية في أي منطقة, .‏ومن خلال البحث الحالي تناول الباحث موضوع العوامل الطبيعية المؤثرة على انتاج المحاصيل الزراعية في ناحية بعشيقة التابعة لقضاء الموصل بمحافظة نينوى .من خلال تحديد التغيرات المكانية لاستعمالات الأرض الزراعية. وبناء قاعدة معلومات جغرافية(Geo-database) تضم البيانات الخاصة بظاهرة منطقة الدراسة المتمثلة بـ (البنية الجيولوجية, والانحدار, وتصنيف الترب وقابليتها الانتاجية) بالإضافة الى المحاصيل الزراعية على هيئة طبقات بحيث تضم كل طبقة (layer) موضوعا محددا, و دراسة عناصر المناخ , ومن ثم بناء نموذج خاص بالملائمة المكانية وانتاج المحاصيل الزراعية لغرض معرفة وتحديد أفضل الأماكن الملاءمة مكانيا باستخدام ادوات التحليل المكاني (Spatial Analysis) للبيانات في برنامجArc GIS V10.4.2 لتكون ذات فائدة مؤكدة كونها تحمل معلومات جديدة مستخلصة أو مستخرجة من التحليل المكاني. ومن ثم تتم عليها عملية التطابق بين خرائط المحاصيل الزراعية مع خريطة الملائمة المكانية التي تم انتاجها. حيث أظهرت الدراسة وجود تطابق بين أفضل الأماكن لزراعية المحاصيل الزراعية مع كمية المحاصيل الزراعية المزروعة فعلا في منطقة الدراسة.
جماليات توظيف الفضاء اللعبي في عروض مسرح الطفل
Authors: ALbajlan Mayada Mjeed , Attalla Iman Abdul Satar 
Published: January 2023

هدف البحث الى دراسة الأبعاد الجمالية للفضاء اللعبي في عروض مسرح الطفل وفق التحولات والأساليب المتنوعة في تشكيل فضاء العرض البصري, لذا شكلت مشكلة البحث في التساؤل التالي: ( ماهي الأساليب الجمالية التي يمكن توظيفها للفضاء اللعبي في عروض مسرح الطفل), وتكمن أهمية البحث في بيان أهمية دور توظيف جماليات الفضاء اللعبي في عروض مسرح الطفل، والبحث يفيد العاملين في المؤسسات التعليمية والتربوية والمؤسسات الثقافية لبناء قاعدة معرفية للجيل الجديد بقصد تعليمهم عن طريق الامتاع البصري والسمعي والحركي والذوق الجمالي.
اما حدود البحث فتمثلت بالعرض المسرحي الموجهة للطفل على خشبة المسرح الوطني للعام(2015) ومن ثم جرى تحديد مصطلحاته، أما الفصل الثاني فيشتمل على مبحثين: الاول تمحور حول (مسرح الطفل والأطر الجمالية) ضمن مفاهيم جمالية عامة في مسرح الطفل، والمبحث الثاني(الفضاء اللعبي وآلية اشتغاله في مسرح الطفل)،كل ما يشغل الفضاء المسرحي من بناء وانشاء سينوغراف في تحقيق الحضور الجمالي المباشر، أما الفصل الثالث: فتشكل من إجراءات البحث ومجتمعه وعينته المتمثلة بمسرحية (أيام الأسبوع الثمانية) بعد أن تتبعت الباحثتان إجراءات البحث وفق المنهج الوصفي(التحليلي)،وشمل الفصل الرابع نتائج البحث فضلا عن التوصيات، والمقترحات، وقائمة المصادر والمراجع، وخلاصة البحث باللغة الإنكليزية .
Discursive Strategies Representing Ideology and Social Power in Stokett’s The Help: A Critical Discourse Analysis
Authors: Ali Abid Hmood , Ammash Manar Hameed 
Published: January 2023

Writers of literary texts rely on multiple linguistic methods and structures, explicitly or implicitly, to reveal their ideas. This study tends to uncover the discursive strategies employed in Stockett’s The Help from a Critical Discourse Analysis perspective. The current study aims to: 1) Showing the discursive strategies in the novel under study. 2) Pinpointing the discursive strategies employed in revealing ideologies in the novel under investigation. 3) Finding out the discursive strategies used in revealing social power in the novel under study.
A number of texts that contain various discursive strategies have been selected for analysis. To fulfill the above aims, the study hypothesizes that: 1) certain discursive strategies are used in the novel under investigation, 2) in terms of the discursive strategies used in the novel under study, some are resorted to more than others, and 3) some ideologies and social power are more commonly revealed than others by way of certain discursive strategies. The novel is analyzed discursively within Fairclough's approach (2001).The most important conclusions, the study has come up are: 1) the discursive strategies employed in the novel under investigation are: presupposition, intertextuality and speech acts, 2) the most commonly discursive strategy by which ideologies are revealed in the novel is intertextuality.
Different hydrocolloid types and concentrations effects towards non-gluten sponge cake's chemical quality and organoleptic
Authors: Lestari Doloksaribu Ayu , Kurnia Hartati Fadjar 
Published: January 2023

The number of people with autism and celiac disease keeps increasing. One of the efforts to assist the healing process naturally is through food consumption that is healthy, safe, and not carelessly, such as providing non-gluten food. The most favoured non-gluten product alternatives are the sponge cake. To produce a soft and elastic non-gluten sponge cake, then hydrocolloid is required. On the other side, the types and amounts of hydrocolloid are varied, depending on the product's types and ingredients.
This research aims to determine the correct type and concentration of hydrocolloid (xanthan gum and guar gum) towards chemical quality and organoleptic of the non-gluten sponge cake from the best cowpea. This research would also help fulfil food availability and diversity for the increasing number of people with autism and celiac disease, reduce the consumption of wheat flour as the gluten source that is now still imported, and utilise and increase consumption of cowpea locally-sourced food.
This research employs Randomised Block Design method consists of two factors: hydrocolloid type factor, which consists of two levels (xanthan gum and guar gum) and hydrocolloid concentration type factor, which consists of three levels (1 gr, 2 gr, and 3 gr). The chemical test parameters involve protein, water, and ash content. The organoleptic test parameters involve colour, aroma, flavour, and texture.
This research resulted in the best treatment of the cowpea sponge cake is at the usage of xanthan gum type on the 2 grams concentration (HIK2) with the highest Result Value of 0.78, with research criteria scores as follows: flavour = 5.7 (like); texture = 5.6 (like); water content = 9.535%; protein content = 4.354%; colour = 5.4 (rather like); and ash content = 1.622%.
PulseRider “jack-up” technique for wide-necked basilar tip aneurysms that incorporate parent arteries: A technical note
Authors: Inoue Satoshi , Fujita Atsushi , Kurihara Eiji , Sasayama Takashi 
Published: January 2023

Background:
Treatment of intracranial wide-necked bifurcation aneurysms remains challenging. We report a novel PulseRider “jack-up” technique for the treatment of wide-necked basilar tip aneurysms.

Case Description:
We performed coil embolization in three patients with an unruptured wide-necked basilar tip aneurysm. Aneurysm neck diameters ranged between 7.6 and 11 mm and dome-to-neck ratios ranged from 1.0 to 1.15. All three aneurysms were very shallow with aspect ratios of 0.51–0.69 and incorporated both posterior cerebral arteries into the aneurysm wall. Because each was difficult to embolize using the standard PulseRider procedure, the PulseRider was deployed more proximally than usual and a coil frame constructed above it. Then, the coil was pushed or “jacked up” into the aneurysm with the PulseRider. Adequate embolization was achieved in all three patients.

Conclusion:
Coil embolization using the PulseRider jack-up technique is effective for treatment of wide-necked basilar tip aneurysms that incorporate parent arteries.
Allele diversity and GJB2-associated hearing loss frequency in Ossetian patients from North Ossetia
Authors: Н.В. Петрова, , И.С. Тебиева, , З.К. Гетоева, , Н.В. Балинова, , А.В. Марахонов, , Т.А. Васильева, , Е.К. Гинтер, , С.И. Куцев, , Р.А. Зинченко, 
Published: January 2023

Патогенные варианты в гене GJB2 являются наиболее частой молекулярной причиной несиндромальной аутосомно рецессивной нейросенсорной тугоухости типа 1 (DFNB1). В работе оценен спектр генетических вариантов и доли GJB2-ассоциированной тугоухости у пациентов с наследственными несиндромальными нарушениями слуха в популяции осетин из Республики Северная Осетия-Алания (РСО-Алания). Проведено секвенирование по Сэнгеру экзонов 1 и 2 гена GJB2 с последующим анализом вариации числа копий локусов путём мультиплексной лигаза-зависимой амплификации зондов (MLPA). Исследование включало 83 пациента с наследственной несиндромальной нейросенсорной тугоухостью из 74 неродственных семей из популяции осетин РСО-Алания. Причина несиндромальной нейросенсорнй тугоухости у осетин в РСО-Алания, обусловленная патогенными вариантами гена GJB2, подтверждена в 26,8% случаев. Два генетических варианта GJB2 (GJB2(NM_004004.6):c.358_360del (p.Glu120del) - 54,2% и GJB2(NM_004004.6):c.35del (p.Gly12ValfsTer2) - 37,5%) составляют 91,7% патогенных аллелей гена GJB2.
Pathogenic variants in the GJB2 gene are the most common molecular cause of nonsyndromic autosomal recessive sensorineural hearing loss type 1 (DFNB1). The aim of the work was to evaluate the spectrum of genetic variants and the proportion of GJB2-associated hearing loss in patients with hereditary non-syndromic hearing disorders in the Ossetian population from the Republic of North Ossetia-Alania. Sanger sequencing of 1 and 2 exons of the GJB2 gene, followed by analysis of the variation in the number of copies of loci by multiplex ligase-dependent amplification (MLPA) was carried out. The study was conducted on a sample of 83 patients with hereditary nonsyndromic sensorineural hearing loss from 74 unrelated families from the population of Ossetians of the Republic of North Ossetia-Alania (RSO-Alania). The cause of nonsyndromic sensorineural hearing loss in Ossetians in the RSO-Alania, due to pathogenic variants of the GJB2 gene, was confirmed in 26.8% of patients. Two genetic variants (GJB2(NM_004004.6):c.358_360del (p.Glu120del)) - 54.2% и GJB2(NM_004004.6):c.35del (p.Gly12ValfsTer2) - 37.5%) account for 91.7% of pathogenic alleles of the GJB2 gene in Ossetian patients.
Informed consent for genetic testing and screening
Authors: В.Л. Ижевская, , Е.Е. Баранова, 
Published: January 2023

Информация, полученная при генетическом тестировании, рассматривается как часть информации о здоровье, но она имеет особый статус, обусловленный ее прогностическим характером, возможностями обнаружения вариантов последовательности ДНК, имеющих отношение к здоровью человека в будущем, но не связанных с первоначальной целью тестирования, потенциальными изменениями интерпретации результатов теста по мере накопления научных знаний, а также с семейным характером. Из-за сложности интерпретации генетической информации и возможных медицинских, психологических и социальных последствий, связанных с генетическим тестированием, требуется получение информированного согласия пациентов или их законных представителей, а также медико-генетическое консультирование до и после тестирования. В обзоре обсуждаются особенности генетической информации и соответствующие особенности информированного согласия при генетическом и геномном тестировании, хранении генетической информации и биообразцов, скрининге новорожденных.
Information obtained from genetic testing is considered as a part of health information, but it has a special status due to its predictive nature, the ability to detect DNA sequence variants that are relevant to human health in the future, but not related to the original purpose of testing, potential changes in interpretation test results as scientific knowledge accumulates, as well as with a family character. Due to the complexity of interpreting genetic information and the potential medical, psychological, and social implications associated with genetic testing, informed consent is required from patients or their legal representatives, as well as genetic counseling before and after testing. The review discusses the features of genetic information and the corresponding features of informed consent in genetic and genomic testing, storage of genetic information and biosamples, and newborn screening.
Treatment of tyrosinemia type 1: practical aspects
Authors: Е.Ю. Захарова, , В.В. Зарубина, , Н.А. Краснощекова, , Н.Л. Печатникова, , В.С. Какаулина, , Т.Н. Кекеева, , Т.В. Бушуева, 
Published: January 2023

Лечение многих болезней, включенных в программу расширенного скрининга новорожденных, предусматривает обязательное применение диетотерапии. Рекомендуемые подходы к лечению тирозинемии 1 типа (ТИР1) включают в себя назначение специализированных пищевых продуктов, фармакологическое лечение препаратом нитизинон - пероральным ингибитором фермента FAH на пути катаболизма тирозина, и симптоматическое лечение. Диетическое вмешательство с ограничением фенилаланина и тирозина вместе с поддерживающими мерами может облегчить симптомы, но, учитывая высокий риск гепатоцеллюлярной карциномы, излечение этих пациентов до сих пор возможно только использованием трансплантации печени. В 2021 году в Российской Федерации опубликованы клинические рекомендации по лечению этого редкого заболевания. Для обеспечения своевременного лечения необходимо, чтобы практикующий врач, занимающийся лечением пациентов с таким редким заболеванием, как ТИР1, обладал знаниями принципов ведения, а также практических алгоритмов расчета диеты. В данной статье на клинических примерах рассмотрены вопросы, касающиеся ведения в период метаболической декомпенсации и правильного подбора диетотерапии пациентам разного возраста, страдающим ТИР1.
Treatment of many of the diseases in the panel of expanded newborn screening includes dietary therapy. Hereditary tyrosinemia type I (HT-I) is inherited metabolic disease caused by defects in tyrosine metabolism and by a mutation in the gene coding for fumarylacetoacetate hydrolase (FAH). The main clinical features of HT-I are caused by hepatic involvement and renal tubular dysfunction. The recommended treatment approaches for HT-1 are the prescription of specialized nutrition products, pharmacologic treatment with nitisinone, a peroral inhibitor of FAH in the tyrosine catabolic pathway, and symptomatic management. Dietary intervention with restriction of phenylalanine and tyrosine together with supportive measures can ameliorate the symptoms, but given the high risk for hepatocellular carcinoma, a cure for these patients so far is possible only with liver transplantation. In 2021, clinical guidelines for the treatment of this rаre disease were published in Russian Federation. To provide for the timely treatment, it is essential for a practitioner involved in the care patients with such a rare disorder as НТ-1 to have the knowledge of the principles of management, as well as practical algorithms for diet calculation. The article gives a detailed case-based description of management during metabolic decompensation and the choice of dietary therapy for HT-1 patients of different age groups.
Damage to cellular DNA is associated with a decrease in the number of the satellite III repeat copies (1q12) in the blood cells DNA of patients with schizophrenia
Authors: Е.М. Жесткова, , Е.С. Ершова, , Н.В. Захарова, , Л.В. Каменева, , Н.Н. Вейко, , С.В. Костюк, 
Published: January 2023

Шизофрения относится к многофакторным заболеваниям, которые возникают как следствие генетических нарушений и неблагоприятных условий эмбрионального развития и жизни человека. В работе обнаружена выраженная отрицательная корреляция между маркерами повреждения ДНК лимфоцитов крови (маркер окисления 8-oxodG, маркер двунитевых разрывов γH2AX) и содержанием повтора - субфракции сателлита III (f-SatIII), локализованного в прицентромерном гетерохроматине 1q12) в выборке больных шизофренией в стадии обострения (N = 97). Низкое содержание повтора f-SatIII в ДНК лейкоцитов больных можно рассматривать в качестве потенциального маркера уровня хронического окислительного стресса и повреждения ДНК при шизофрении.
Schizophrenia is a multifactorial disease resulting from genetic disorders and unfavorable conditions of embryonic development and later life. The study revealed a pronounced negative correlation between markers of DNA damage in blood lymphocytes (oxidation marker 8-oxodG, double-strand break marker γH2AX) and the repeat content - satellite III subfraction (located in pericentromeric heterochromatin 1q12) in a sample of patients with schizophrenia in the acute stage (N = 97). The low content of the f-SatIII repeat in the DNA of leukocytes of patients can be considered as a potential marker of the level of both chronic oxidative stress and DNA damage in schizophrenia.