bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular basis for cellular retinoic acid-binding protein 1 in modulating CaMKII activation
Authors: Nhieu Jennifer , Miller Michelle C. , Lerdall Thomas A. , Mayo Kevin H. , Wei Li-Na 
Published: September 2023

Introduction: Cellular retinoic acid (RA)-binding protein 1 (CRABP1) is a highly conserved protein comprised of an anti-parallel, beta-barrel, and a helix-turn-helix segment outside this barrel. Functionally, CRABP1 is thought to bind and sequester cytosolic RA. Recently, CRABP1 has been established as a major mediator of rapid, non-genomic activity of RA in the cytosol, referred to as “non-canonical” activity. Previously, we have reported that CRABP1 interacts with and dampens the activation of calcium-calmodulin (Ca2+-CaM)-dependent kinase 2 (CaMKII), a major effector of Ca2+ signaling. Through biophysical, molecular, and cellular assays, we, herein, elucidate the molecular and structural mechanisms underlying the action of CRABP1 in dampening CaMKII activation.Results: We identify an interaction surface on CRABP1 for CaMKII binding, located on the beta-sheet surface of the barrel, and an allosteric region within the helix segment outside the barrel, where both are important for interacting with CaMKII. Molecular studies reveal that CRABP1 preferentially associates with the inactive form of CaMKII, thereby dampening CaMKII activation. Alanine mutagenesis of residues implicated in the CaMKII interaction results in either a loss of this preference or a shift of CRABP1 from associating with the inactive CaMKII to associating with the active CaMKII, which corresponds to changes in CRABP1’s effect in modulating CaMKII activation.Conclusions: This is the first study to elucidate the molecular and structural basis for CRABP1’s function in modulating CaMKII activation. These results further shed insights into CRABP1’s functional involvement in multiple signaling pathways, as well as its extremely high sequence conservation across species and over evolution.
Breaking the cycle: unraveling the diagnostic, pathophysiological and treatment challenges of refractory migraine
Authors: Robblee Jennifer 
Published: September 2023

BackgroundRefractory migraine is a poorly described complication of migraine in which migraine has chronified and become resistant to standard treatments. The true prevalence is unknown, but medication resistance is common in headache clinic patient populations. Given the lack of response to treatment, this patient population is extremely difficult to treat with limited guidance in the literature.ObjectiveTo review the diagnostic, pathophysiological, and management challenges in the refractory migraine population.DiscussionThere are no accepted, or even ICHD-3 appendix, diagnostic criteria for refractory migraine though several proposed criteria exist. Current proposed criteria often have low bars for refractoriness while also not meeting the needs of pediatrics, lower socioeconomic status, and developing nations. Pathophysiology is unknown but can be hypothesized as a persistent “on” state as a progression from chronic migraine with increasing central sensitization, but there may be heterogeneity in the underlying pathophysiology. No guidelines exist for treatment of refractory migraine; once all guideline-based treatments are tried, treatment consists of n-of-1 treatment trials paired with non-pharmacologic management.ConclusionRefractory migraine is poorly described diagnostically, its pathophysiology can only be guessed at by extension of chronic migraine, and treatment is more the art than science of medicine. Navigating care of this refractory population will require multidisciplinary care models and an emphasis on future research to answer these unknowns.
Multi-parameter MRI based radiomics nomogram for predicting telomerase reverse transcriptase promoter mutation and prognosis in glioblastoma
Authors: Chen Ling , Chen Runrong , Li Tao , Tang Chuyun , Li Yao , Zeng Zisan 
Published: September 2023

ObjectiveTo investigate the clinical utility of multi-parameter MRI-based radiomics nomogram for predicting telomerase reverse transcriptase (TERT) promoter mutation status and prognosis in adult glioblastoma (GBM).MethodsWe retrospectively analyzed MRI and pathological data of 152 GBM patients. A total of 2,832 radiomics features were extracted and filtered from preoperative MRI images. A radiomics nomogram was created on the basis of radiomics signature (rad-score) and clinical traits. The performance of the nomogram in TERT mutation identification was assessed using receiver operating characteristic (ROC) curve, calibration curves, and clinical decision curves. Pathologically confirmed TERT mutations and risk score-based TERT mutations were employed to assess patient prognosis, respectively.ResultsThe random forest (RF) algorithm outperformed the other two algorithms, yielding the best diagnostic efficacy in differentiating TERT mutations, with area under the curve (AUC) values of 0.892 (95% CI: 0.828–0.956) and 0.824 (95% CI: 0.677–0.971) in the training set and validation sets, respectively. Furthermore, the predictive power of the radiomics nomogram constructed with the rad-score and clinical variables reached 0.916 (95%CI: 0.864, 0.968) in the training set and 0.880 (95%CI: 0.743, 1) in the validation set. Calibration curve and decision curve analysis findings further uphold the clinical application value of the radiomics nomogram. The overall survival of the high-risk subgroup was significantly shorter than that of the low-risk subgroup, which was consistent with the results of the pathologically confirmed TERT mutation group.ConclusionThe radiomics nomogram could non-invasively provide promising insights for predicting TERT mutations and prognosis in GBM patients with excellent identification and calibration abilities.
Irrigation scheduling for potatoes (Solanum tuberosum L.) under drip irrigation in an arid region using AquaCrop model
Authors: Yin Juan , Yang Yingpan , Eeswaran Rasu , Yang Zhen , Ma Zhenghu , Sun Fubin 
Published: September 2023

Potato is one of the key food crops and China is the largest potato producer in the world. However water scarcity is the major constraint to increase the productivity of potato in the arid regions such as Ningxia in northwest China where this crop is extensively cultivated. The overall objective of this study was to optimize the irrigation for potato cultivated under the drip irrigation. To do this, the AquaCrop model was calibrated and validated using the data obtained from two years of field experiment. Then, the calibrated crop model was used to simulate growth and tuber yield of potato in response to 30 different irrigation schemes under two different irrigation scenarios. The crop model evaluation parameters namely, the root mean square error (RMSE), the index of agreement (d), the normalized root mean square error (NRMSE) and the coefficient of determination (R2) showed that the AquaCrop model could simulate the growth and yield of potato under the drip irrigation with different irrigation treatments with reasonable accuracy. Furthermore, yield of potato has increased with increasing amount of total irrigation under drip irrigation; however, yield begins to decline when the amount of total irrigation exceeds 2500 m3 ha-1. The study also found that the optimum irrigation schedule for potato was 20 mm of irrigation quota at 7 days of irrigation cycle (i.e., 1800 m3 ha-1 or 180 mm of total irrigation). The above irrigation scheduling has achieved 46.77 t ha-1 of tuber yield with 15.74 kg m-3 of water use efficiency. These findings may be evaluated in potato cultivation across different climate and soil conditions for wide applicability at different arid regions of the world.
Chinese EFL learners’ empowerment: does teacher care and confirmation matter?
Authors: Li Min , Chu Zhesen 
Published: September 2023

IntroductionInspired by the rhetorical/relational goal theory, the current inquiry evaluated the role of two teacher relational behaviors, namely care and confirmation, in predicting Chinese EFL learners’ empowerment.MethodsTo do this, we administered three closed-ended scales to 391 Chinese students who studying English as a foreign language in various educational institutions in China. Students’ attitudes toward the interplay between teacher care, teacher confirmation, and learner empowerment were statistically analyzed using IBM SPSS Amos software.ResultsThe results uncovered that teacher confirmation and teacher care serve an essential role in improving Chinese EFL learners’ empowerment. This indicates that EFL learners’ empowerment strictly depends on the relational behaviors that teachers employ in instructional-learning contexts.DiscussionThe study outcomes may have some theoretical and practical implications for L2 researchers, language teachers, and teacher trainers.
Association between intoxication with psychoactive substances and adverse effects occurrence in consumers
Authors: Amanollahi Alireza , Shadnia Shahin , Mehrabi Yadollah , Etemad Koorosh 
Published: September 2023

BackgroundThe prevalence of psychoactive substance use is increasing worldwide and identifying adverse effects of these types of drugs is necessary in intoxicated patients.ObjectiveWe aimed to investigate the association of psychoactive substance intoxication with their adverse effects on the functioning of the bodily organs.MethodsThis was a single-center study between March 2019 and April 2022 on intoxicated patients with psychoactive substances. Inclusion criteria were intoxication with alcohol, opioids, and stimulants, and having available results of laboratory biomarkers. Demographic and clinical data of patients at the time of admission as well as during hospitalization were reviewed, retrospectively. Data were analyzed using a generalized linear mixed model in R software and the Adjusted Odds Ratio (AOR) was estimated.ResultsA total of 800 hospitalized patients in the ICU (n = 400) and general ward (n = 400) were divided into two groups of intoxicated with alcohol (n = 200) and opioids or stimulants (n = 200). Liver (AOR = 0.15, p = 0.033; AOR = 0.13, p = 0.007) and kidney (AOR = 0.46, p = 0.004; AOR = 0.24, p = 0.021) dysfunction occurred less in the ICU and general ward, respectively, in opioids or stimulants intoxication compared to alcohol. Cardiovascular dysfunctions occurred more in opioids or stimulants intoxication compared to alcohol in both ICU (AOR = 10.32, p &lt; 0.0001) and general ward (AOR = 4.74, p &lt; 0.0001).ConclusionKidney dysfunctions had a greater effect on mortality compared to other dysfunctions. During the follow-up, the incidence of dysfunctions increased in those intoxicated with opioids or stimulants. Men experienced more liver and kidney dysfunctions as well as mortality, but psychoactive substance experience was a protective factor in cardiovascular dysfunctions and mortality.
Artificial intelligence in postharvest agriculture: mapping a research agenda
Authors: Fadiji Tobi , Bokaba Tebogo , Fawole Olaniyi Amos , Twinomurinzi Hossana 
Published: September 2023

IntroductionThe implementation of artificial intelligence (AI) in postharvest agriculture has significantly improved in recent decades, thanks to extensive scientific research. The study aimed to identify research gaps and hotspots for future research based on keyword co-occurrence and clustering analyses, as well as to discuss the results and highlight the research trends.MethodsThis study analyses research trends in AI application in postharvest agriculture using novel scientometric tools such as the Bibliometrix R package, biblioshiny, and VosViewer. The research analysed 586 published papers on AI application in postharvest agriculture research between 1994 and September 2022, retrieved from the Scopus database.Results and discussionThe results showed that publications on AI applications in postharvest agriculture research have been increasing for almost 30 years, with significant growth in the subject area in the last decade. China, the USA, and India were found to be the top three most productive countries, accounting for 52.4%, 22%, and 18.6% of the total selected publications, respectively. The analysis also revealed that topics such as the Internet of Things, cold chain logistics, big data, decision-making, and real-time monitoring have low development degrees in the knowledge domain. This study demonstrated increased research on AI applications in postharvest agriculture, aiming to reduce postharvest losses, enhance food nutrition and quality, and mitigate food insecurity. It also provides valuable scientific references on AI applications in postharvest agriculture research for researchers and scholars. By identifying research gaps and hotspots, this study can guide future research in AI applications in postharvest agriculture to further improve the industry.
Association Between Pandemic Fatigue and Disease Knowledge, Attitudes, Concerns, and Vaccination Intention at Two Key Moments of the COVID-19 Pandemic
Authors: Agurto-Ramírez Adriana , Pino-Rosón Candela , Ayala Alba , Falcón María , Rodríguez-Blázquez Carmen , Forjaz Maria João , Romay-Barja María 
Published: September 2023

Objective:This study aimed to describe the change in knowledge, attitudes, concerns, perceptions, preventive practices, and vaccination intention at two key time points of the COVID-19 pandemic and to assess whether these changes varied by level of pandemic fatigue.Methods:Data included in this study came from the third and the ninth round of the COSMO-Spain cross-sectional study. A general linear model was used to investigate the interaction terms between rounds and levels of pandemic fatigue.Results:Changes between rounds were observed in knowledge, attitudes, concerns, perceptions, behaviours, and vaccination intention. Significant interactions between rounds indicated that those with low levels of pandemic fatigue had a greater increase in knowledge, lower decrease in concerns, greater decrease in agreement with the decisions made, and lower increase in vaccination intention compared with those with high pandemic fatigue.Conclusion:As a pandemic evolves, it becomes necessary to consider the level of pandemic fatigue of the population and how this affects knowledge, concerns, and agreement with the measures adopted, as they influence the population’s adherence to public health recommendations aimed at controlling infections and protecting the most vulnerable.
Utilization of anticoagulant and antiplatelet medications among geriatric patients with neurosurgical diseases
Authors: Al-Mirza Abdulrahman , Al-Taei Omar , Al-Saadi Hatem , Al-Saadi Tariq 
Published: September 2023

Aim: To study the utilization patterns of anticoagulant and antiplatelet medications among geriatric patients with neurosurgical conditions in the neurosurgical department at Khoula Hospital, Muscat, Sultanate of Oman.

Introduction: Anticoagulant and antiplatelet presumption is a worry in neurosurgical patients, that suggests a subtle balance between the risk of thromboembolism against the risk of peri- and postoperative haemorrhage. Patients taking those medications were found to have an increased risk of bleeding from traumatic and traumatic events.

Materials and Methods: A retrospective study of geriatric cases admitted to the Neurosurgery Department in Khoula Hospital (KH) as an example of a neurosurgical center in Sultanate of Oman, from January 2016 to 31st December 2019. Patients demographics, diagnosis, length of hospital stay (LOS), Glasgow Coma Scale (GCS), length of ICU admission, and treatment proposed were recorded.

Results: The most common diagnostic category was trauma (35.4%). 16.0 % of the patients were taking anticoagulant medications. Patients with traumatic brain injury (TBI) were found to have a higher rate of using anticoagulant medications (36.6%). There was a significant difference between the LOS, type of intervention, ICU admission, and the usage of anticoagulant and antiplatelet drugs (p<0.05). Enoxaparin was the most commonly used anticoagulant agent. 19.6 % of the patients were taking antiplatelet medications. This study was showed that aspirin is the most commonly used antiplatelet agent among different neurosurgical pathologies.

Conclusion: Patients with TBI were found to have a higher rate of using anticoagulant medications. Decisions regarding prescription and resumption of anticoagulants and antiplatelet medications should be taken on a case-by-case basis involves multidisciplinary and holistic approaches.
Lumbar disc herniation presenting with contralateral neuropathy
Authors: Balasa D. , Popescu C. 
Published: September 2023

We admitted a unique case of right lumbar disc herniation at L4L5 who presented with contralateral symptoms and was successfully treated with a right large L4/L5 fenestration and microdiscectomy.
When the operation is considered, intervention only from the herniation side is sufficient.
In the case presented, it is probable that Kernohan notch?like phenomenon, venous engorgement and congestion at the contralateral side of the herniated lumbar disc and the contralateral migrated epidural fat are responsible for the emergence of contralateral symptoms.
Brain abscess – a still high mortality medical condition
Authors: Popescu George , Zaharia Marius C. , Georghiu Ana-Maria , David Bogdan-Ionuț , Ioniță Ana-Maria , Vijlanescu Cezar , Gorgan Radu M. 
Published: September 2023

Background. Even in the 21st century, infections of the central nervous system and their secondary damage still represents a high mortality condition. Furthermore, brain abscesses (BA) are huge public health issues due to their high mortality and morbidity with high financial implications for the health care system.
Material and methods. In this article, we want to present our clinic`s experience in the management of brain abscesses between 2012 and 2021. A 10 years retrospective study was performed in the 4th Neurosurgery Department of “Bagdasar-Arseni” Clinical Emergency Hospital in Bucharest
Results. In the last 10 years, our clinic admitted 46 patients, 10 women and 36 men. The mean age was 47 years old. The most common symptom was headache (42 cases). In 39 cases, patients had solitary abscesses while seven patients presented multiple abscesses. The therapeutic approach was classic surgery in 37 cases. In four cases abscess drainage was performed and in five cases conservative treatment was used. At discharge, 31 patients were healed and seven patients died.
Discussions. In BA management, antimicrobial therapy is crucial. Thus, identifying the pathogen is crucial for accurate antimicrobial treatment. Unfortunately, in too many cases, the agent remains unknown and empiric treatment is required. Aspiration of the abscesses proved to be safe and with similar results compared to classic surgery.
Conclusions. Brain abscesses remain a high challenge to manage even in the 21st century. Broad-spectrum antibiotic treatment should be applied as soon as possible until the pathogen is identified and specific treatment will be used.
Black cumin 0.3 gram and 0.4 gram on apoptotic levels in Cerebral Contusions Rattus Norvegicus Wistar
Authors: Nazwar Tommy Alfandy , Balafif Farhad , Wardhana Donny Wisnu , Annas Muhammad , Anab Agus Chairul , Istiadjid E.S. M. 
Published: September 2023

Background. Apoptosis is one of the indicators to check for following brain damage. Along with this trend, treatment in the form of herbal and phytopharmaca therapy is required more frequently to treat brain injury complications. Black cumin possesses a function that opposes the apoptotic mechanism.
Objectives. This study sought to determine the effect of black seed on an animal model of brain damage using apoptotic measures.
Methods. Four treatment groups were created from the experimental animals as follows: Group BC1: For 7 days following the brain contusion, they were given [0.3 gram] g/kg bw of black cumin extract daily. Group BC2: For 7 days following the brain contusion, they were given [0.4 gram] g/kg bw of black cumin extract daily. Following the brain contusion, Group K received 3 ml of Nacl 0.9% daily for 7 days. The TUNEL DNA fragmentation method was used to count the amount of apoptotic cells and analysis was conducted using ANOVA with F-test and Tukey HSD.
Results. The control group had the greatest amount of apoptosis at 30.4. Apoptosis averages for BC1 (0.3 g), and BC2 (0.4 g) groups of rats were 25.0, and 18.8, respectively. Black cumin anova test with apoptosis was present while a higher dose of black cumin will minimize the amount of apoptosis.
Conclusions. Injecting black cumin extracts into rats with head injuries reduced apoptosis, albeit not significantly. In rats with experimental head injuries, black cumin extract induces a connection through the apoptosis mechanism.
Conservative management of intraventricular migrating intracranial bullet
Authors: Saheb Amjed Hassan , Al-Taie Rania H. , Farooq Ibrahim A. , Taha Abbas Musaab , Naser Hawraa Sadeq , Yaseen Zahraa Mohammed , Ismail Mustafa , Hoz Samer S. 
Published: September 2023

Background. The high mortality rate of a cranial bullet injury, the catastrophic damage of vital tissue, and the frequency of gunshot accidents made managing such cases highly effortful in neurosurgical trauma centres. One category of these injuries is the gravitational bullet injury, in which the bullet's movement depends on gravity after losing its kinetic energy. This paper aims to describe the conservative treatment plan we applied for a patient who suffered an intracranial gravitational bullet injury.
Case description. The patient presented with a cranial bullet injury that migrated caudally to his lateral ventricle. This unapproachable location of the bullet made the surgical intervention undoable. Therefore, after the implication of resuscitative management, the patient went under heavy observation with a suitable follow-up plan. The patient's short-term outcome was excellent, and his Glasgow coma scale was 15 at the discharge.
Conclusion. Conservative management in a gravitational bullet is one of the possible methods to reach the best outcome in non-operable patients. Such measures are highlighted in this case, even when a complication like a bullet migration may occur.
Spontaneous complete resolution of a giant cavernous carotid aneurysm in the setting of ipsilateral ICA occlusion
Authors: Talib Sura H. , Sharma Mayur , Ramanathan Vishan P. , Alfawares Yara , Almufadhal Muntadher H. , Ismail Mustafa , Hoz Samer S. 
Published: September 2023

Background. Cavernous carotid aneurysms (CCA) are rare aneurysms with a relatively benign natural history. The association between CCA aneurysm and ipsilateral Internal carotid artery (ICA) thrombosis or occlusion has not been described previously. The management of patients with these dual lesions is a challenging problem.
Case description. In this report, we describe an 18-year-old man who presented with left abducent nerve palsy of 3 weeks duration, and imaging revealed left CCA with left ICA occlusion. The patient was managed conservatively with clinical and imaging follow-up. The patient recovered well with complete resolution of clinical symptoms and disappearance of left CCA.
Conclusions. The association of giant CCA and ICA occlusion on the same side is a rare phenomenon with no current consensus on the appropriate follow-up and management strategy. In this report, we described the first case of spontaneous complete disappearance of a giant CCA in the setting of ipsilateral ICA occlusion with complete resolution of symptoms at nine months of follow-up.