bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D MXene‐Based Flexible Network for High‐Performance Pressure Sensor with a Wide Temperature Range
Authors: Xie Yimei , Cheng Yongfa , Ma Yanan , Wang Jian , Zou Junjie , Wu Han , Yue Yang , Li Baowen , Gao Yihua , Zhang Xin , Nan Ce‐Wen 
Published: December 2022

AbstractWith the increasing popularity of smart wearable devices, flexible pressure sensors are highly desired in various complex application scenarios. A great challenge for existing flexible pressure sensors is to maintain high sensitivity over a wide temperature range, which is critical for their applications in harsh environments. Herein, a flexible piezoresistive sensor made of polyetherimide (PEI) fibrous network evenly covered with MXene nanosheets is reported to construct conductive pathways, showing ultrahigh sensitivity over a wide temperature range from −5 °C (sensitivity of 80 kPa−1) to 150 °C (20 kPa−1), low detection limit of 9 Pa, fast response time of 163 ms, outstanding durability over 10 000 cycles at room temperature, 2000 cycles at 100 °C and 500 cycles at −5 °C. The pressure sensor can monitor various human activities in real‐time, apply to human–machine interaction, and measure pressure distribution. It also can sensitively respond to external mechanical stimuli at 150 °C and extremely low temperature (in liquid nitrogen). Moreover, the fibrous network exhibits an excellent Joule heating performance, which can reach 78 °C at an applied voltage of 12 V. Thus, the piezoresistive sensor has considerable potential for wearable garments and personal heating applications in harsh temperature conditions.
Allosteric Activation of 15‐Lipoxygenase‐1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation
Authors: Börner Friedemann , Pace Simona , Jordan Paul M. , Gerstmeier Jana , Gomez Mario , Rossi Antonietta , Gilbert Nathaniel C. , Newcomer Marcia E. , Werz Oliver 
Published: December 2022

AbstractSpecialized pro‐resolving mediators (SPM), primarily produced in innate immune cells, exert crucial bioactions for resolving inflammation. Among various lipoxygenases (LOX), 15‐LOX‐1 is key for SPM biosynthesis, but cellular activation principles of 15‐LOX‐1 are unexplored. It was shown that 3‐O‐acetyl‐11‐keto‐β‐boswellic acid (AKBA) shifts 5‐LOX regiospecificity from 5‐ to 12‐lipoxygenation products. Here, it is demonstrated that AKBA additionally activates cellular 15‐LOX‐1 via an allosteric site accomplishing robust SPM formation in innate immune cells, particularly in M2 macrophages. Compared to ionophore, AKBA‐induced LOX activation is Ca2+‐ and phosphorylation‐independent, with modest induction of 5‐LOX products. AKBA docks into a groove between the catalytic and regulatory domains of 15‐LOX‐1 interacting with R98; replacement of R98 by alanine abolishes AKBA‐induced 15‐LOX product formation in HEK293 cells. In zymosan‐induced murine peritonitis, AKBA strikingly elevates SPM levels and promotes inflammation resolution. Together, targeted allosteric modulation of LOX activities governs SPM formation and offers new concepts for inflammation resolution pharmacotherapy.
Manipulation of PD‐L1 Endosomal Trafficking Promotes Anticancer Immunity
Authors: Ye Zuodong , Xiong Yiding , Peng Wang , Wei Wenjie , Huang Lihong , Yue Juliana , Zhang Chunyuan , Lin Ge , Huang Feng , Zhang Liang , Zheng Songguo , Yue Jianbo 
Published: December 2022

AbstractThe aberrant regulation of PD‐L1 in tumor cells remains poorly understood. Here, the authors systematically investigate the endosomal trafficking of plasma membrane PD‐L1 in tumor cells. They show that plasma membrane PD‐L1 is continuously internalized, and then trafficked from early endosomes to multivesicular bodies/late endosomes, recycling endosomes, lysosomes, and/or extracellular vesicles (EVs). This constitutive endocytic trafficking of PD‐L1 is Rab5‐ and clathrin‐dependent. Triazine compound 6J1 blocks the endosomal trafficking of PD‐L1 and induces its accumulation in endocytic vesicles by activating Rab5. 6J1 also promotes exosomal PD‐L1 secretion by activating Rab27. Together, these effects result in a decrease in the membrane level of PD‐L1 in 6J1‐treated tumor cells and enables tumor cells to be more susceptible to the tumor‐killing activity of T cells in vitro. 6J1 also increases tumor‐infiltrating cytotoxic T cells and promotes chemokines secretion in the tumor microenvironment. Rab27 knockdown abolishes 6J1‐induced PD‐L1 secretion in EVs and revokes the exhausted tumor‐infiltrating T cells in tumors, thereby improving the anticancer efficacy of 6J1. Furthermore, a combination of 6J1 and an anti‐PD‐1 antibody significantly improves the anticancer immune response. Therefore, manipulating PD‐L1 endosomal trafficking provides a promising means to promote an anticancer immune response in addition to the immune checkpoint‐blocking antibody therapy.
Effects of pubertal growth variation on knee mechanics during walking in female and male adolescents
Authors: Froehle Andrew W. , Edwards Brian , Peterson Matthew J. , Meyerson Brian , Duren Dana L. 
Published: December 2022

AbstractIntroductionPuberty substantially alters the body's mechanical properties, neuromuscular control, and sex differences therein, likely contributing to increased, sex‐biased knee injury risk during adolescence. Female adolescents have higher risk for knee injuries than male adolescents of similar age engaging in similar physical activities, and much research has investigated sex differences in mechanical risk factors. However, few studies address the considerable variation in pubertal growth (timing, pace), knee mechanics, and injury susceptibility within sexes, or the impact of such growth variation on mechanical injury risk.ObjectivesThe present study tested for effects of variation in pubertal growth on established mechanical knee injury risk factors, examining relationships between and within sexes.MethodsPubertal growth indices describing variation in the timing and rate of pubertal growth were developed using principal component analysis and auxological data from serial stature measurements. Linear mixed models were applied to evaluate relationships between these indices and knee mechanics during walking in a sample of adolescents.ResultsLater developing female adolescents with slower pubertal growth had higher extension moments throughout stance, whereas earlier developers had higher valgus knee angles and moments. In male adolescents, faster and later growth were related to higher extension moments throughout gait. In both sexes, faster growers had higher internal rotation moments at foot‐strike.ConclusionsPubertal growth variation has important effects on mechanical knee injury risk in adolescence, affecting females and males differently. Earlier developing females exhibit greater injury risk via frontal plane factors, whereas later/faster developing males have elevated risk via sagittal plane mechanisms.
Food availability influences birth seasonality at a small spatial scale in endangered golden monkeys (Cercopithecus mitis kandti)
Authors: Tuyisingize Deogratias , Eckardt Winnie , Kaplin Beth A. , Stoinski Tara S. , Caillaud Damien 
Published: December 2022

AbstractObjectivesStudying reproductive seasonality helps us understand changes in the energetically demanding periods of pregnancy and lactation. We investigated how diet variability and key food plant phenology relate to mating and birth seasonality in both remaining populations of endangered golden monkeys in the Virunga massif and the Gishwati forest in Rwanda.Material and MethodsUsing scan and ad libitum sampling, we recorded feeding, mating, and births in two social groups (K and M) living in Volcanoes National Park (VNP), in the Virunga massif, from 2004 to 2018, and in one group (G) in the Gishwati forest in 2017–2018. We also monitored bamboo shoot and fruit availability in the groups' home ranges in 2017–2018.ResultsMating was observed year‐round but peaked four to 6 months prior to each group's respective birth season. Despite the two VNP groups ranging only 16 km apart, they had different birth seasons. Females from group K gave birth during the late bamboo growing season, from September to December, while females from group M gave birth during the early bamboo shooting season, from February to April. This pattern was linked to differences in the availability and consumption of bamboo shoots between low‐elevation (group K) and high‐elevation (group M) habitat. In group G, births occurred from March to April, coinciding with the period of high fruit availability and consumption in the Gishwati forest.DiscussionOur findings suggest that food availability shapes golden monkey birth seasons, even at a small spatial scale. Current changes in key food plant regeneration, potentially driven by climate change, need to be closely monitored to inform golden monkey conservation management.
Counting homelessness: Working creatively to generate complex descriptive profiles of the health and demographics of people experiencing homelessness in Adelaide
Authors: Flavel Joanne , Wood Lisa , Freeman Toby , Vallesi Shannen , Foley Kristen , Parry Yvonne , Baum Fran 
Published: December 2022

AbstractAnalyses of the prevalence of homelessness suggest homelessness is increasing in Australia and other countries. Yet, difficulties exist in obtaining an accurate picture of homelessness due to a dearth of robust data and inconsistent definitions. This study aimed to build a comprehensive descriptive profile of homelessness and associated health needs in Adelaide. Five data sources were analysed and compared to produce descriptive sociodemographic and health statistics. Across data sources, people experiencing homelessness had a high prevalence of poor health outcomes and service utilisation. Consistent with the international literature, high rates of physical and mental health conditions were reported, including depression, anxiety and dental problems. While there was variability in demographic data, Aboriginal and Torres Strait Islander peoples were consistently over‐represented. Analysing data from multiple sources provided a richer understanding of who is experiencing homelessness and their health needs, highlights it is not always necessary to collect new data to overcome dataset limitations and illustrates how data comparison can improve the use of existing data. The paper concludes with reflections on the challenges and potential of the methodology. Overall, the study shows analysing data from multiple sources can provide rich information to service providers and government departments to inform more nuanced and effective services.
Plasma p‐tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease
Authors: Aguillon David , Langella Stephanie , Chen Yinghua , Sanchez Justin S. , Su Yi , Vila‐Castelar Clara , Vasquez Daniel , Zetterberg Henrik , Hansson Oskar , Dage Jeffrey L. , Janelidze Shorena , Chen Kewei , Fox‐Fuller Joshua T. , Aduen Paula , Martinez Jairo E. , Garcia Gloria , Baena Ana , Guzman Claudia , Johnson Keith A. , Sperling Reisa A. , Blennow Kaj , Reiman Eric M. , Lopera Francisco , Quiroz Yakeel T. 
Published: December 2022

AbstractIntroductionPlasma‐measured tau phosphorylated at threonine 217 (p‐tau217) is a potential non‐invasive biomarker of Alzheimer's disease (AD). We investigated whether plasma p‐tau217 predicts subsequent cognition and positron emission tomography (PET) markers of pathology in autosomal dominant AD.MethodsWe analyzed baseline levels of plasma p‐tau217 and its associations with amyloid PET, tau PET, and word list delayed recall measured 7.61 years later in non‐demented age‐ and education‐matched presenilin‐1 E280A carriers (n = 24) and non‐carrier (n = 20) family members.ResultsCarriers had higher plasma p‐tau217 levels than non‐carriers. Baseline plasma p‐tau217 was associated with subsequent amyloid and tau PET pathology levels and cognitive function.DiscussionOur findings suggest that plasma p‐tau217 predicts subsequent brain pathological burden and memory performance in presenilin‐1 E280A carriers. These results provide support for plasma p‐tau217 as a minimally invasive diagnostic and prognostic biomarker for AD, with potential utility in clinical practice and trials.Highlights
Non‐demented presenilin‐1 E280A carriers have higher plasma tau phosphorylated at threonine 217 (p‐tau217) than do age‐matched non‐carriers.
Higher baseline p‐tau217 is associated with greater future amyloid positron emission tomography (PET) pathology burden.
Higher baseline p‐tau217 is associated with greater future tau PET pathology burden.
Higher baseline p‐tau217 is associated with worse future memory performance.
Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus
Authors: Payet Cloé A. , You Axel , Fayet Odessa‐Maud , Hemery Edouard , Truffault Frederique , Bondet Vincent , Duffy Darragh , Michel Frédérique , Fadel Elie , Guihaire Julien , Demeret Sophie , Berrih‐Aknin Sonia , Le Panse Rozen 
Published: December 2022

ObjectiveMyasthenia gravis (MG) is a neuromuscular disease mediated by antibodies against the acetylcholine receptor (AChR). The thymus plays a primary role in AChR‐MG and is characterized by a type I interferon (IFN) signature linked to IFN‐β. We investigated if AChR‐MG was characterized by an IFN‐I signature in the blood, and further investigated the chronic thymic IFN‐I signature.MethodsSerum levels of IFN‐β and IFN‐α subtypes, and mRNA expression for IFN‐I subtypes and IFN‐stimulated genes in peripheral mononuclear blood cells (PBMCs) were analyzed. The contribution of endogenous nucleic acids in thymic expression of IFN‐I subtypes was investigated in human thymic epithelial cell cultures and the mouse thymus. By immunohistochemistry, thymic CD68+ and CD163+ macrophages were analyzed in AChR‐MG. To investigate the impact of a decrease in thymic macrophages, mice were treated with an anti‐CSF1R antibody.ResultsNo IFN‐I signature was observed in the periphery emphasizing that the IFN‐I signature is restricted to the MG thymus. Molecules mimicking endogenous dsDNA signalization (Poly(dA:dT) and 2′3′‐cGAMP), or dexamethasone‐induced necrotic thymocytes increased IFN‐β and α‐AChR expression by thymic epithelial cells, and in the mouse thymus. A significant decrease in thymic macrophages was demonstrated in AChR‐MG. In mice, a decrease in thymic macrophages led to an increase of necrotic thymocytes associated with IFN‐β and α‐AChR expression.InterpretationThese results suggest that the decrease of thymic macrophages in AChR‐MG impairs the elimination of apoptotic thymocytes favoring the release of endogenous nucleic acids from necrotic thymocytes. In this inflammatory context, thymic epithelial cells may overexpress IFN‐β, which specifically induces α‐AChR, resulting in self‐sensitization and thymic changes leading to AChR‐MG. ANN NEUROL 2023;93:643–654
Unveiling Dopant‐Induced Ultrafast Exciton Dynamics in Mn/Yb Codoped Perovskite Nanocrystals
Authors: Niu Weifan , Zhang Ruidan , Wang Zhibin , Huang Feng , Chen Daqin 
Published: December 2022

AbstractPerovskite nanocrystals (NCs) with intentionally introduced Mn2+/Yb3+ activators enable tunable emissions covering UV‐orange‐NIR spectral range. However, the exact microscopic energy transfer mechanisms in this system remain unknown. Herein, Mn/Yb codoped CsPbCl3 perovskite NCs with triple emissions originated from exciton recombination of host, 3d–3d transition of Mn2+ and 4f–4f transition of Yb3+ are prepared. Femtosecond resolution transient absorption spectra performed on the pristine CsPbCl3, Mn‐doped, Yb‐doped and Mn/Yb codoped samples clarify efficient and simultaneous energy transfer (ET) from excitons to Mn2+ and Yb3+ dopants. It is testified the sensitizations of dopants mainly result from the trapped hole, taking 285 ps for Mn2+ and 17 ps for Yb3+ respectively, which make less trapped hole recombine with de‐localized carriers. Importantly, energy transfer processes from host to Mn2+ and Yb3+ activators emerge as competition, and the ET probability of exciton‐to‐Mn2+ is higher than that of exciton‐to‐Yb3+. Finally, control experiments further prove that tunable Mn2+ orange emission and Yb3+ NIR emission are achievable via elaborate adjustment of the dopant concentrations.
Morphogenetic progression of thigh and lower leg muscles during human embryonic development
Authors: Yamaguchi Yutaka , Kodama Ryota , Yamada Shigehito 
Published: December 2022

AbstractFetal musculoskeletal movements are first observed at approximately seven to 8 weeks of gestation. However, the separation and formation of skeletal muscles, especially the limbs, have not yet been described in detail. In this study, we elucidate the sequence of events leading to the formation of each thigh and lower leg muscle using serial sections. To observe muscle formation, 26 serial sections (50 legs) of human embryonic specimens ranging from Carnegie stages (CS) 19 to 23 were selected from the Kyoto collection stored at the Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine. As a result, we show the detailed formation and separation processes of the thigh and lower leg muscles. In the thigh, sartorius and tensor fasciae latae are separated at CS19, and the individual muscles observed in adults are identified after CS21. In the lower leg, the tibialis anterior exhibits early separation at CS20, and all muscles are identified at CS22. This study enables future research into the relationship between embryonic development and the evolution of muscle action from quadrupedal to erect bipedal walking.
π‐System Functionalization Transforms Amyloidogenic Peptide Fragment of Human Islet Amyloid Polypeptide into a Super Hydrogelator
Authors: Unnikrishnan Anagha C. , Sushana Thennarasu Abinaya , Saveri Puchalapalli , Pandurangan Suryalakshmi , Deshpande Abhijit P. , Ayyadurai Niraikulam , Shanmugam Ganesh 
Published: December 2022

AbstractWhile a considerable number of ultra‐short/short amyloid peptides have been reported to form 3D supramolecular hydrogels, they all possess high minimum gelation concentration (MGC) (≥1 wt%), which preclude their applications. In this context, we demonstrate that functionalisation of a well‐known amyloidogenic ultra‐short peptide fragment NFGAIL (IAPf) of human Islet amyloid polypeptide with a π‐system (Fluorenyl, Fm) at the N‐terminus of the peptide (Fm‐IAPf) yield not only highly thermostable hydrogel at physiological pH but also exhibited super gelator nature as the MGC (0.08 wt%) falls below 0.1 wt%. Various experimental results confirmed that aromatic π–π interactions from fluorenyl moieties and hydrogen bonding interactions between the IAPf drive the self‐assembly/fibril formation. Fm‐IAPf is the first super hydrogelator derived from amyloid‐based ultra‐short peptides, to the best of our knowledge. We strongly believe that this report, i. e., functionalization of an amyloid peptide with π‐system, provides a lead to develop super hydrogelators from other amyloid‐forming peptide fragments for their potential applications.
Unraveling Factors Affecting Performance of Quinone‐based Polymer Cathode in Aqueous Zinc‐Ion Battery
Authors: Yang Xiao , Zhao Yi , Xu Qiuju , Yuan Xiangcheng , Liu Jinzhang 
Published: December 2022

AbstractOrganic cathode materials for aqueous rechargeable Zinc‐ion batteries (ZIBs) include a large variety of aromatic molecules with redox‐activity, and such polymer molecules vary largely in terms of specific capacity, discharge voltage plateau, and cycling stability. Here, three different quinone polymers are prepared by electropolymerizing dihydroxynaphthalene (DHN) isomers of 1,5‐DHN, 1,6‐DHN, and 1,7‐DHN, respectively, and their energy storage performances in aqueous ZIBs are compared. Among the three cathode materials, the poly(1,6‐DHN) cathode shows the best performance in specific capacity and cycling stability. The Zn||poly(1,6‐DHN) cell shows a high areal capacity of 1.4 mAh cm−2 and a high capacity retention of 90 % after 5000 cycles. By combing experiment with computation, the HOMO level of the polymer molecule is found to play a key role behind the specific capacity. Using the poly(1,7‐DHN) cathode that suffers from faster capacity decay in the cycling process, our investigation suggests that residual ions stuck between molecular chains in the insertion/deinsertion process account for the capacity loss. This study provides a further understanding of organic cathode materials for aqueous ZIBs.
Improving sandwich variance estimation for marginal Cox analysis of cluster randomized trials
Authors: Wang Xueqi , Turner Elizabeth L. , Li Fan 
Published: December 2022

AbstractCluster randomized trials (CRTs) frequently recruit a small number of clusters, therefore necessitating the application of small‐sample corrections for valid inference. A recent systematic review indicated that CRTs reporting right‐censored, time‐to‐event outcomes are not uncommon and that the marginal Cox proportional hazards model is one of the common approaches used for primary analysis. While small‐sample corrections have been studied under marginal models with continuous, binary, and count outcomes, no prior research has been devoted to the development and evaluation of bias‐corrected sandwich variance estimators when clustered time‐to‐event outcomes are analyzed by the marginal Cox model. To improve current practice, we propose nine bias‐corrected sandwich variance estimators for the analysis of CRTs using the marginal Cox model and report on a simulation study to evaluate their small‐sample properties. Our results indicate that the optimal choice of bias‐corrected sandwich variance estimator for CRTs with survival outcomes can depend on the variability of cluster sizes and can also slightly differ whether it is evaluated according to relative bias or type I error rate. Finally, we illustrate the new variance estimators in a real‐world CRT where the conclusion about intervention effectiveness differs depending on the use of small‐sample bias corrections. The proposed sandwich variance estimators are implemented in an R package CoxBcv.
Using bodily displays to facilitating approach action outcomes within the context of a personally relevant task
Authors: Elkjær Emma , Mikkelsen Mai B. , Tramm Gitte , Michalak Johannes , Mennin Douglas S. , O'Toole Mia S. 
Published: December 2022

AbstractBackgroundConsiderable attention has been paid to the effect of bodily (expansive and contractive) displays on affective, behavioral, and hormonal outcomes. However, the majority of past studies are limited by a lack of control groups with neutral displays and low personal relevance of the experimental tasks employed. The present study aimed to investigate the effect of adopting different bodily displays, including neutral displays, within the context of a personally relevant task.MethodsIn an experiment with healthy participants (N = 90), we investigated the effects of two different bodily manipulations (i.e., expansive and contractive), compared to a control group (i.e., neutral displays). Effects were evaluated in terms of completed valued action in addition to processes considered potentially helpful in preparing and motivating the individual to take valued action, including a change in emotion experience, action tendencies, and appraisals.ResultsSeveral main effects were detected and only few significant interaction effects were revealed. In case of group differences, results showed that expansive bodily displays outperformed the control group, leading to more positive emotions, more approach action tendencies, less negative emotion variability, and less avoidance action tendencies toward threat.DiscussionThese results mainly suggest that identifying a valued action and explicating the underlying motivational conflict may be beneficial regardless of bodily displays. This conclusion runs somewhat counter both to our hypotheses and to findings in recent meta‐analytic work. However, previous experiments have not evaluated the effect of bodily displays within a personally relevant context.