bluuebunny/crossref_metadata_2025_split huggingface dataset:
Issues, Groups, or Idiots? Comparing Theories of Partisan Stereotypes
Authors: Myers C Daniel 
Published: September 2023

AbstractWhen individuals picture the two parties, what do they think of? Given the dominant understanding of partisanship as a social identity, understanding the content of these mental images—individuals’ stereotypes of the two parties—is essential, as stereotypes play an important role in how identity affects attitudes and behaviors, perceptions of others, and inter-group relations. The existing literature offers three answers to this question: one that claims that people picture the two parties in terms of their constituent social groups, a second that claims that people picture the two parties in terms of policy positions, and a third that claims that people view the two parties in terms of individual traits they associate with partisans. While not mutually exclusive, these theories have different implications for the effects of partisanship and the roots of partisan animosity. This paper adjudicates between these theories by employing a new method that measures stereotype content at the collective and individual level using a conjoint experiment. An important advantage of the conjoint measure is that it allows for the direct comparison of the importance of different attributes, and different kinds of attributes, to the stereotype. Using a pre-registered 2,909-person survey, I evaluate the relative importance of issues, groups, and traits to stereotypes of partisans. I find strong evidence that issue positions and ideological labels are the central elements of partisan stereotypes. I also find that individuals who hold issue- or ideology-based stereotypes are more affectively polarized than those whose stereotypes are rooted in groups or traits.
Harmonic And Neutral Spherical Elastic Inhomogeneities with A Functionally Graded Interphase Layer
Authors: Wang Xu , Schiavone Peter 
Published: September 2023

Summary
We study the elastic field in a three-phase composite composed of an internal spherical homogeneous elastic inhomogeneity, an intermediate functionally graded interphase layer and an outer unbounded homogeneous elastic matrix subjected to an arbitrary uniform remote loading. The shear modulus of the interphase layer obeys a power law distribution along the radial direction. We accomplish the design of harmonic and neutral spherical elastic inhomogeneities. Specifically, the shear modulus of the matrix can be judiciously chosen in such a way that the insertion of the harmonic spherical inhomogeneity does not disturb the original constant mean stress in the surrounding matrix. The shear modulus of the matrix and relative thickness of the interphase can also be suitably chosen such that the insertion of the neutral spherical inhomogeneity does not disturb the original uniform deviatoric stresses in the surrounding matrix.
Influence of sex hormone use on sleep architecture in a transgender cohort
Authors: Morssinkhof Margot W L , van der Werf Ysbrand D , van den Heuvel Odile A , van den Ende Daan A , van der Tuuk Karin , den Heijer Martin , Broekman Birit F P 
Published: September 2023

Abstract

Study Objectives
Sex differences in sleep architecture are well-documented, with females experiencing longer total sleep time, more slow wave sleep (SWS), and shorter Rapid Eye Movement (REM) sleep duration than males. Although studies imply that sex hormones could affect sleep, research on exogenous sex hormones on sleep architecture is still inconclusive. This study examined sleep architecture changes in transgender individuals after 3 months of gender-affirming hormone therapy (GAHT).

Methods
We assessed sleep architecture in 73 transgender individuals: 38 transmasculine participants who started using testosterone and 35 transfeminine participants who started using estrogens and antiandrogens. Sleep architecture was measured before GAHT and after 3 months of GAHT for 7 nights using an ambulatory single-electrode sleep EEG device. Changes in sleep architecture were analyzed using linear mixed models, and non-normally distributed outcomes were log-transformed and reported as percentages.

Results
In transmasculine participants, SWS decreased by 7 minutes (95% CI: −12; −3) and 1.7% (95% CI: −3%; −0.5%), REM sleep latency decreased by 39% (95% CI: −52%; −22%) and REM sleep duration increased by 17 minutes (95% CI: 7; 26) after 3 months of GAHT. In transfeminine participants, sleep architecture showed no significant changes after 3 months of GAHT.

Conclusions
Sleep architecture changes after 3 months of masculinizing GAHT in line with sleep in cisgender males, while it shows no changes after feminizing GAHT. The sex-specific nature of these changes raises new questions about sex hormones and sleep. Future research should focus on studying possible underlying neural mechanisms and clinical consequences of these changes.
Clinical profile of infants with late onset sepsis admitted in a North East Indian tertiary care center: insights into the uncharted
Authors: Niranjana Sugunan , Singh Chongtham Shyamsunder , Devi Khuraijam Ranjana , Singh O Okendrajit , Smilie Chabungbam , Nandeibam Sareet Kumari 
Published: September 2023

Abstract

Objectives
To assess the clinical profile of infants with late onset sepsis admitted in a tertiary care hospital in North-East India.

Methods
Prospective observational study was carried out in Department of Paediatrics, Regional Institute of Medical Sciences hospital during a period of 2 years (September 2019–August 2021).

Results
A total of 109 patients were included in the study, of which 80 were community-acquired and 29 infants were hospital-acquired cases of late onset sepsis (LOS). The major risk factors were low socioeconomic status, prematurity, low birth weight, a history of intervention (mechanical ventilation, umbilical venous catheter, total parenteral nutrition, resuscitation) and lack of exclusive breastfeeding. The most common presenting features were decreased feeding, lethargy and respiratory distress. Blood cultures were positive in 33% of patients. Klebsiella was the most common hospital-acquired pathogen while Escherichia coli was the most common isolate in community-acquired cases. Thrombocytopenia was the most common complication. The in-hospital mortality rate was 13.7%.

Conclusion
Low socioeconomic status, low birth weight, prematurity, invasive interventions and lack of exclusive breastfeeding are the major risk factors of LOS. The clinical signs and symptoms are varied and subtle. The mean C-reactive protein in the hospital-acquired group was significantly higher as compared to the community-acquired group. There is substantial morbidity and mortality, resulting in an increased toll on resources, therefore, an aggressive preventive and treatment approach is recommended for late onset sepsis.
Top of the food chains: an ecological network of the marine Paja Formation biota from the Early Cretaceous of Colombia reveals the highest trophic levels ever estimated
Authors: Cortés Dirley , Larsson Hans C E 
Published: September 2023

Abstract
The Mesozoic Marine Revolution restructured the world’s ocean biodiversity into the complex marine ecosystems of today. This revolution began during the Triassic but the origin of this complexity is poorly understood due to a lack of detailed ecosystem reconstructions throughout time. We present the first site-specific ecological network for a marine Mesozoic fauna based on the Early Cretaceous Paja Formation biota of Colombia that preserves numerous, large-bodied, predatory marine reptiles. The trophic food-web was quantitatively reconstructed based on inferred trophic interactions of marine producers, consumers, and large apex predators. Compared to well-studied Caribbean reef ecosystem networks, the Paja biota network is missing a great proportion of benthic invertebrates and fishes, despite its rich higher trophic levels. We hypothesize that the ammonites from the Paja biota either mirrored the diversity represented by some fishes today or established a novel trophic unit with no living analogue. Recalibrating the Paja biota network to trophic analogues in the Caribbean, such as sea turtles, estimates that the largest Paja marine reptile hyper-apex predators occupied trophic levels a full tier higher than any extant marine apex predator. The Paja biota network is a starting point to tracing the evolution of marine ecosystems across the Mesozoic Marine Revolution.
Molecular mechanism of oroxyli semen against triple-negative breast cancer verified by bioinformatics and in vitro experiments
Authors: Chen Lulu , Yang Aishen , Li Yangan , Liu Xin , Jiang Wei , Hu Kehui 
Published: September 2023

Objective:
This study aimed to use network pharmacology to predict the therapeutic mechanism of oroxyli semen (OS) on triple-negative breast cancer (TNBC) and validate it through in vitro experiments.

Methods:
The active ingredients and target proteins of OS were retrieved from the Traditional Chinese Medicine Systems Pharmacology database, and the TNBC-related target genes were obtained from the GeneCards database. The overlapping genes were used to construct a protein–protein interaction (PPI) network via the String database. Furthermore, we employed an online bioinformatics analysis platform (https://www.bioinformatics.com.cn/) to perform gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses to evaluate biological processes, molecular functions, and cellular components and generate simulated signal pathways. Additionally, molecular docking was used to evaluate the binding ability of small molecule drugs and signaling pathway targets. CCK8 assay was conducted to detect the effect of small molecule drugs on TNBC cell viability, and Western Blot was utilized to verify the expression of AKT, VEGF, and hypoxia-inducible factor 1-alpha (HIF-1α) proteins.

Results:
Fifteen active ingredients and 166 therapeutic targets of OS were obtained from the Traditional Chinese Medicine Systems Pharmacology database. The Venn diagram revealed that 163 targets were related to TNBC. The protein–protein interaction network analysis identified AKT1, IL-6, JUN, vascular endothelial growth factor A (VEGFA), CASP3, and HIF-1α as potential core targets through which OS may treat TNBC. Furthermore, the molecular docking results indicated that the active ingredient chryseriol in OS had good binding ability with VEGFA, and HIF-1α. CCK8 assay results indicated that chryseriol inhibited the viability of MDA-MB-231 and BT-20 cells. Western Blot demonstrated that chryseriol intervention led to a decrease in VEGFA, and HIF-1α protein expression compared with the control group (P < .05), increased the cleaved PARP.

Conclusion:
OS may exert its therapeutic effects on TNBC through multiple cellular signaling pathways. Chryseriol, the active component of OS, can enhance the apoptosis of TNBC cells by targeting VEGFA/HIF-1α pathway. This study provided new insights into the potential therapeutic mechanism of OS for TNBC and may aid in the development of novel therapeutic approaches for TNBC.
Efficacy of acupotomy combined with sodium hyaluronate versus sodium hyaluronate alone in the treatment of knee osteoarthritis: A meta-analysis
Authors: Wu Qinglin , Wu Zuqing , Lu Zhifu 
Published: September 2023

Background:
The efficacy of acupotomy combined with hyaluronic sodium acid in the treatment of knee osteoarthritis (KOA) is unclear. Therefore, this meta-analysis aims to evaluate the efficacy of acupotomy combined with hyaluronic sodium acid compared with hyaluronic sodium acid alone in the treatment of KOA.

Methods:
Studies from 8 Online databases were searched on KOA treatment using acupotomy combined with sodium hyaluronate until May 2022. The primary outcome indicator was clinical effectiveness, and the secondary outcome indicators included the visual analogue scale scores and Lysholm scores. We calculated the weighted mean difference (WMD) or relative risk for all relevant outcomes.

Results:
Nine studies were identified, involving 644 cases. The results showed that acupotomy combined with intra-articular sodium hyaluronate injection for KOA was superior to sodium hyaluronate injection alone in terms of clinical effectiveness (relative risk = 1.17, 95% confidence interval [CI]: 1.09–1.25, P < .001) and visual analogue scale (WMD = −2.1, 95% CI: −2.25 to 1.95, P < .001), Lysholm score (WMD = 13.83, 95% CI: 3.47–24.19, P = .009).

Conclusion:
Acupotomy combined with intra-articular sodium hyaluronate injection for KOA is superior to sodium hyaluronate injection alone. Limited by the number and quality of included studies, this conclusion still needs to be verified by more high-quality Research.

INPLASY registration number:
INPLASY202350029.
A rare complication of people with inflammatory bowel disease after ileostomy: A case report
Authors: Jiang Hong , He Shengduo , Wang Huahong 
Published: September 2023

Rationale:
Venous thromboembolism is one of the common complications of inflammatory bowel disease (IBD), which is a significant health problem worldwide. Factors such as inflammation, medications, and abdominal surgery, contribute to the increased risk of venous thromboembolism in patients with IBD. Cavernous transformation of the portal vein (CTPV) is a relatively rare complications of IBD. Subsequent portal hypertension could be fatal and the clinical treatment is difficult. Thus, early prevention is very crucial.

Patient concerns:
A 55-year-old man presented to our department with asthenia, hematemesis, and diarrhea. He was diagnosed with Crohn disease for 9 years. Two years ago, He suffered intestinal perforation and received enterectomy and ileostomy. And, anticoagulants were not given during perioperative period and after surgery because of the history of gastrointestinal bleeding.

Diagnoses:
The patient was given endoscopy inspection showing the varices of esophagus and gastric fundus near cardia. Contrast enhancement CT scan showed portal hypertension, CTPV, gastroesophageal varices, and splenomegaly. Then percutaneous transhepatic portography was performed to make a clear diagnosis.

Interventions:
Concerned about the risk of surgery, he refused surgical shunting. Conservative treatment was recommended due to technical difficulties instead of interventional therapy.

Outcomes:
And after a period of fasting, blood transfusion, and parenteral nutrition treatment, the patient did not experience any further vomiting or hematemesis.

Lessons:
Early identification and treatment of CTPV is difficult. Prevention such as early application of anticoagulant is necessary for patients with IBD undergoing surgery, particularly with simultaneous stoma formation. For IBD patients who are not suitable for anticoagulant therapy, postoperative follow-up monitoring should be more frequent and monitoring time should be extended.
lncRNA HOTAIR promotes ROS generation and NLRP3 inflammasome activation by inhibiting Nrf2 in diabetic retinopathy
Authors: You Hui , Li Hongyu , Gou Wenjun 
Published: September 2023

Background:
Diabetic retinopathy (DR) is a microvascular complication associated with damage to the retina due to inflammation induced by high glucose. Activation of the NLRP3 inflammasome plays a critical role in DR and its prevention is beneficial to patients. However, the regulation of long non-coding RNA (lncRNA) in NLRP3 inflammasome activation of DR is incompletely understood. So, this study aimed to uncover the functional and regulatory mechanism of the lncRNA HOTAIR in NLRP3 inflammasome activation in Dr

Methods:
The vitreous humor was collected from the patients and detected the inflammatory and oxidative stress makers. Human retinal endothelial cells (HRECs) were cultured and stimulated in low D-glucose (5 mmol/L) or high D-glucose (20 mmol/L). Additionally, HRECs were knocked down HOTAIR with a si-RNA. Then, the NLRP3 inflammasome activation was analyzed by western blotting and pyroptosis cell imaging. The ROS was measured by specific probe. The activation of Nrf2 measured by Immunofluorescent staining. The interaction between HOTAIR and Nrf2 was evaluated by co-immunoprecipitation and RNA immunoprecipitation.

Results:
The expression of HOTAIR was significantly increased in the vitreous of patients with DR and in HRECs stimulated with high glucose. Furthermore, HOTAIR knockdown relieved NLRP3 inflammasome activation. More specifically, HOTAIR knockdown suppressed the expression of NLRP3, pro-caspase-1, and pro-IL-1β, as well as IL-1β maturation and pyroptosis. HOTAIR knockdown also interfered with the ROS generation induced by high glucose. Moreover, HOTAIR promoted the interaction between Nrf2 and Keap1 by binding and inactivating Nrf2.

Conclusion:
The lncRNA HOTAIR promotes NLRP3 inflammasome activation and ROS generation by inhibiting Nrf2 in Dr
Network pharmacology and molecular docking predictions of the active compounds and mechanism of action of Huangkui capsule for the treatment of idiopathic membranous nephropathy
Authors: Cai Meng , Xiang Yongjing , Li Zhengsheng , Xie Juan , Wen Fulong 
Published: September 2023

Background:
Huangkui Capsule is a single herbal concoction prepared from the flower of Abelmoschus manihot, which is used to treat idiopathic membranous nephropathy (IMN), a frequent pathologically damaging kidney condition. It has been widely utilized to treat a variety of renal disorders, including IMN, in clinical practice. However, the active compounds and mechanism of action underlying the anti-IMN effects of Huangkui Capsule remain unclear. In this study, we aimed to predict the potential active compounds and molecular targets of Huangkui Capsule for the treatment of IMN.

Methods:
The possible active components of Huangkui were located using the SymMap v2 database. The targets of these drugs were predicted using Swiss Target Prediction, while IMN-related genes with association scores under 5 were gathered from the GeneCards and DisGeNET databases. The common targets of the disease and the components were determined using VENNY 2.1. Using Cytoscape 3.8.0, a drug-disease network diagram was created. Molecular docking was carried out with Pymol, AutoDock Tools, and AutoDock Vina.

Results:
With 1260 IMN-related illness genes gathered from GeneCards and DisGeNET databases, we were able to identify 5 potentially active chemicals and their 169 target proteins in Huangkui. Based on degree value, the top 6 targets for Huangkui treatment of IMN were chosen, including AKT, MAPK3, PPARG, MMP9, ESR1, and KDR.

Conclusion:
This work theoretically explains the mechanism of action of Huangkui Capsule in treating IMN and offers a foundation for using Huangkui Capsule in treating IMN in clinical settings. The findings require additional experimental validation.
Clinical and radiological features of a case of primary encephalitis induced by SARS-CoV-2 omicron variant infection: A case report
Authors: Zhang Xiong , Hu Ruiting , Zhao Fanyu 
Published: September 2023

Rationale:
In 2022, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron spread widely around the world. In the context of most literature reporting weakened virulence of the virus, immunocompromised patients who have not been vaccinated should be vigilant for the development of encephalitis following SARS-CoV-2 infection.

Patient concerns:
A 58-year-old male patient with immunodeficiency presented with respiratory and psychiatric symptoms after contracting SARS-CoV-2 Omicron variant.

Diagnoses:
The patient was diagnosed with coronavirus disease 2019 infection and associated acute primary encephalitis.

Interventions:
The patient was received comprehensive treatment including Azvudine antiviral therapy, immunoglobulin infusion, and methylprednisolone anti-inflammatory therapy.

Outcomes:
The patient’s condition improved and he was discharged smoothly. One month after discharge, the patient returned for follow-up, and the occipital lobe still had a few slow waves on electroencephalogram, but the patient reported no seizure events since discharge.

Lessons:
During the prevalence of the SARS-CoV-2 Omicron variant, we believe that it is still necessary to be vigilant about immunocompromised patients developing encephalitis. Early use of cranial magnetic resonance imaging as a diagnostic assistance is conducive to early diagnosis and treatment of patients.
Pancreatic Acinar Cystic Transformation
Authors: Aguilera Munoz Lina , Boros Carina , Bonvalet Fanny , Ronot Maxime , Rebours Vinciane 
Published: September 2023

Abstract
Pancreatic acinar cystic transformation (ACT) is a recently described entity of the pancreatic cysts' spectrum. It is a nonneoplastic pancreatic lesion, mostly asymptomatic, and is considered a rare disease, with less than 100 reported cases. Its benign nature and the absence of reported cases of malignant transformation or invasive lesions were a plea for a conservative approach. As a consequence, little is known about the pathogenesis of this lesion. No familial history of ACT has been previously described. Here, we report a familial case of 2 siblings with typical ACT imaging lesions giving evidence for familial aggregation. No obvious environmental exposure was identified as a potential risk factor for ACT development. No physiological data exist to suggest a congenital nature of these lesions, but for the first patient, the calcifications seem to have appeared with time. Further research, with high throughput sequencing technologies, may elucidate genetic polymorphisms explaining potential ACT familial phenotype. In practice, careful family history collection must be performed to identify a possible familial form of ACT when this diagnosis is proposed.
Lactated Ringer's or Normal Saline for Initial Resuscitation in Patients Hospitalized With Acute Pancreatitis
Authors: Antoniak Derrick , Twohig Patrick , Olson Kristin , Samson Kaeli , Mitchell Christine , Eichele Derrick 
Published: September 2023

Objectives
Fluid resuscitation is required in acute pancreatitis (AP) to prevent hypovolemia and organ hypoperfusion. Lactated Ringer's (LR) is a buffered crystalloid with possible advantages in AP versus normal saline (NS). We aim to assess outcomes in patients hospitalized with AP based on fluid used for resuscitation.

Methods
In this retrospective analysis, we identified hospital admissions to Veterans Affairs facilities for AP from 2011 to 2017 and grouped by initial resuscitation fluid: LR versus NS. Outcomes included major complications and mortality at 30 and 365 days. Multivariable models were used to adjust for confounding variables.

Results
A total of 20,049 admissions were included in the study, of which 10% received LR as initial fluid. After adjustment for all available confounders, resuscitation with LR was associated with lower 1-year mortality compared with NS (adjusted odds ratio, 0.61 [95% confidence interval, 0.50–0.76]). Major complication and early mortality were similar between groups.

Conclusions
In this study, we demonstrate an association between use of LR as initial resuscitation fluid and reduced 1-year mortality in a large retrospective sample of veterans hospitalized with AP. These results support the use of LR for resuscitation for most patients hospitalized with AP.