bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remdesivir use for COVID-19 patients: Rates of serum creatinine levels to baseline or to upper limits to monitor postadministration renal function
Authors: Yoshida Junichi , Shiraishi Kenichiro , Kikuchi Tetsuya , Tanaka Masao 
Published: May 2023

Abstract
Objectives: The incidence of remdesivir-induced renal dysfunction has not been investigated until now. The present study explored the clinical factors and laboratory data that predict remdesivir-induced renal dysfunction.
The subjects were COVID-19 patients and we determined the endpoint as dialysis or death within 29 days. Background status parameters included (1) estimated glomerular filtration rate < 30 ml/min/1.73 m2, (2) serum creatinine (SCr) ratios to baseline > 1.5, (3) SCr ratios to upper limits > 1.5, (4) alanine aminotransferase ratios to upper limits > 5, (5) administration days, (6) sex, (7) age, (8) height, (9) weight, (10) dexamethasone use, and (11) SARS-CoV-2 vaccination.
Results: In a total of 490 patients, a multivariate analysis showed that status (2) (odds ratio [OR] 8.342, 95% confidence interval [CI] 1.589-43.788, P=0.012) and status (7) (OR 7.620, CI 1.181-49.169, P=0.033) at 72 years or more were significant factors for remdesivir-induced renal dysfunction. To monitor renal function after remdesivir administration in COVID-19 patients, SCr ratios to baseline may work better than those to the upper limits.
Psychometric properties and latent classes of the Attachment Style Questionnaire in mothers and their offspring
Authors: Blake Julie , Thomas Hannah , Hurst Cameron , Pelecanos Anita , McGee Tara , Najman Jake , Scott James 
Published: May 2023

Abstract
Background The Attachment Style Questionnaire (ASQ) is used to assess an individual’s inner working model of interpersonal relationships and attachment style. The study evaluated the factor structure, sex invariance, and convergent validity of the ASQ among middle-aged women and their young adult offspring.Methods Middle aged mothers (n = 3,605, Mage=46.5 years) and their 3,712 offspring were administered the ASQ when their offspring were young adults (Mage=21.6-years). Symptom measures of anxiety and depression were concurrently administered to mothers (Delusions Symptoms States Inventory) and offspring (Young Adult Self-Report). Confirmatory factor analyses were conducted to test the structural validity in both groups as well as sex invariance in the offspring cohort. Convergent and divergent validity were assessed using depression/anxiety subscales. Latent class analyses (LCA) were performed to examine patterns of responses across ASQ items.Results Confirmatory analyses supported the utility of a shortened 33-item ASQ for both cohorts, and the structure was invariant between male and female offspring. Strong convergence was found between anxious subscales on the ASQ and depression/anxiety symptoms in both cohorts. Measures of anxiety and depression correlated positively with ASQ anxiety and avoidance subscales. LCA identified four latent classes across a continuum of secure and insecure attachment rather than four distinct attachment styles (i.e., Bartholomew & Horowitz, 1991).Conclusions The ASQ-33 is a reliable and valid instrument that measures internal working models of relationships in both male and female young adults, and women in middle-age. Findings support a dimensional view of attachment security/insecurity over the four-part categorisation of attachment styles.
Clinical and pathological factors affecting the accuracy of liquid-based oral cytology for oral potentially malignant disorders
Authors: Miyazaki Ryo , Ishikawa Ryou , Sukegawa Shintaro , Goda Mamoru , Haba Reiji , Nakai Fumi , Nakai Yasuhiro , Ishihama Takanori , Miyake Minoru 
Published: May 2023

Abstract
Background
Early detection and early treatment are important for oral squamous cell carcinoma (SCC), and liquid-based cytology (LBC) is a convenient and easy method for detecting malignancies. However, achieving an accurate diagnosis of potential malignancies of the oral cavity remains challenging. We investigated clinical factors that are important for oral cytology diagnoses.
Materials and Methods
We retrospectively analyzed the pathological diagnoses of 133 LBC samples obtained at Kagawa University Hospital. The samples' cytological diagnoses were based on Papanicolaou staging. We investigated samples of oral epithelial dysplasia (OED)(n = 35), carcinoma in situ (CIS) (n = 13), and SCC (n = 85) to determine the associations between the clinicopathological features and the false negative rate (FNR) by the χ2-test.
Results
Our analyses demonstrated that OED (n = 14), CIS (n = 6), and SCC (n = 5) had been misdiagnosed as negative (class 2). Age (≤ 64 or > 65 years; p = 0.0391), whitening of the lesion (p = 0.0054), and the ulcer of the lesion (p = 0.0034) were significantly associated with the FNR. No significance was observed for sex, smoking, or alcohol consumption.
Conclusion
Our results indicate that despite the limitations of LBC and regardless of clinical features, LBC is a simple and useful supplementary method to detect oral cancers.
A Proposed Cognitive Framework Model for a Student Support Voice based Chatbot using XAI
Authors: Ghosh Debmitra , Ghatak Sayani , Paul Hrithik 
Published: May 2023

Abstract
As the calling agent directly calls and makes interaction (checking for valid phone numbers before calling) with the user such as using a pie event, even the agent can also record the conversation and transcribe information. The other voice chat agent is capable of taking voice input as well as text input. The user's information can be interpreted by it. And lastly, make a CSV or xlsx file of the user's input. The model has been designed in such a way that it can convert the voice provided as input by the user and analyze the sentiments contained in it by converting it into text using the speech-to-text module of the pyaudio package in Python. In the case of data cleaning, special characters have been removed from the .JSON file and provided to the NLTK tokenizer. When the model has been successfully built, users can enter their queries through voice and text, and the model will predict based on the text entered. The model first deciphers the voice entered quantitatively and ascertains the pitch, decibel, and amplitude, and enumerates a categorical cross-validation of the voice with the parameters that are set. It undergoes polarity checking under the positive and negative polarity counter and then the values of the positive and negative polarities of the text are stored in the program. When the agent finally works, it takes into account all the aspects with which it is trained, and provides the perfect outcome. If the user also enters the incorrect dialogue on their phone, the call will instantly cease. After that, we'll use an api post request to create and establish a connection. When it comes to encouraging different individuals to call for admission-related or medical-related reasons, the calling agent has a huge effect on that issue. In some cases, the user's number has been used. In this paper we have designed and implemented automation testing framework for testing web applications. This new automation testing framework has been implemented using selenium WebDriver tool. Using this framework tester can easily write their test cases efficiently and in less time. Tester need not to study the selenium web driver tool in detail. This framework is helpful to developer to analyze their code due to screen shot property of framework. This framework produces the customized test report to tester. It is very easy to maintain and repair the test suite for new release of the application using this framework. Software organizations are more committed to creating high-quality software solutions at lower costs. Previously, manual testing was used, but due to the increased complexity of the program, testing automation is now required. Selenium, GUI testing, Cross Browser testing, and Web automation are used more effectively. we used Selenium web driver Python to accomplish Web Automation testing.
Continuum of Maternal Health Care Services and its impact on Adverse Birth Outcomes in North Shoa Zone: An Application of the Propensity Score Matching Approach
Authors: Moges Wudneh , Seyoum Awoke , Mitiku Aweke A , Zewotir Temesgen , Hailemeskel Solomon , Tesfahun Esubalew 
Published: May 2023

Abstract

BackgroundThe World Health Organization (WHO) defined: - low birth weight as a weight at birth less than 2500g. Adverse birth outcomes, low birth weight, and preterm birth, constitute an important danger to public health since they raise the likelihood of future diseases and developmental problems for children as well as fetal health status at birth. The study aimed to investigate propensity score methods for causal inference by removing selection bias from observational studies for adverse birth outcomes.MethodsWe analyzed quasi-experimental studies for the maternal and neonatal health outcome datasets, including adverse birth outcomes for allocated groups of mothers within the period of time from August 2019 to September 2020. We applied different propensity score algorithms, matching, inverse probability weighting, stratification and overlap weighting for covariate balance between midwives-led continuity care and shared model care for adverse birth outcomes.ResultsThe result of the current investigation indicates that mothers who were provided midwife-led continuity (OR=0.48, 95% CI∶( 0.35, 0.894)) with inverse probability treatment weighting (OR=0.36, 95% CI: (0.19, 0.69)) had significant contribution for the improvement of advance birth outcomes.ConclusionMidwife-led continuity care of mothers had a significant enrollment for improving adverse birth outcomes of newborn babies and the propensity score has only controls for measured covariates, propensity score methods are the most recommended approach to adjust confounding and recover treatment effects.
Biochar-ZnO /Polyaniline Composite in Energy Storage Application: Synthesis, Characterization and Electrochemical Analysis
Authors: Thomas Diana , Fernandez Noeline , Mullassery Manohar , R Surya 
Published: May 2023

Abstract
Carbon materials displaying electrical double capacitance are widely used in the electrochemical energy storage devices. To enhance the electrochemical performance, compositing carbon with transition metal oxides and conducting polymers have been very much appreciated. A novel and effective approach to prepare a high energy density and high specific capacitance composite electrode material from a biomass is presented in the work. Pyrolysis of biomass at 500 oC in the nitrogen atmosphere yielded a biochar (BC) with well-developed porosity, surface functionality and suitable morphological characteristics. Anchoring ZnO nanoparticles on BC and subsequently coating it with a conducting polymeric material, polyaniline (PANI) obtained the hierarchical BC-ZnO/PANI composite. Both BC-ZnO and BC-ZnO/PANI composites have been characterized by FTIR, UV-Visible, XRD, SEM and TEM studies. The characteristic signals at 2θ values 18.5ᵒ, 28.4ᵒ,24.0ᵒ and 31.4ᵒ in XRD correspond to wurtzite structure of ZnO nanoparticles. ZnO rod like structural morphology was confirmed by SEM analysis. The maximum specific capacitance was found to be 110.0 F/g for BC-ZnO and 198.0 F/g for BC-ZnO/PANI. Furthermore, the ternary composite displayed low solution resistance and charge transfer resistance as evident from the Nyquist plots proved that PANI coating is a promising methodology in the fabrication of electrode materials for energy storage applications.
A robust hydroponic-based system for screening red clover (Trifoliorum pratense) for Fusarium avenaceum
Authors: Jambagi Shridhar , Dixelius Christina 
Published: May 2023

Abstract
Background Red clover (Trifolium pratense) is an important forage legume crop that suffers like most perennial crops from attacks by soilborne pathogens. Fusarium root rot is one of the most serious diseases and at the same time problematic to identify resistance to due to its hidden life in the soil. Current screening methods are laborious and hampered by limited reproducibility. To remedy this situation, we aimed to establish a more undemanding and reliable system to facilitate studies of red clover-Fusarium avenaceum interactions.Results First, the fungal spore concentrations were balanced toward the development of red clover plants grown hydroponically. We found that the optimum concentration was 30,000 spores in 2 L of hydroponic medium to ensure infection during the plant growth period in this system. The procedure was scaled-up to screen twenty-five populations to identify red clover genotypes with the most contrasting responses to F. avenaceum. Susceptible plants had approximately 2-fold higher amounts of fungal DNA than resistant plants, demonstrating a correlation between the disease readings of the plants and pathogen DNA.Conclusions A hydroponics-based screening system was established to facilitate reproducible and rapid screening of Fusarium root rot disease in red clover. We foresee this screening procedure meeting the needs of both applied breeding work and in-depth molecular studies of responses between this pathogen and its host plant. This method could be applied for the screening of other plant species for resistance to Fusarium spp. or to other root microbes.
A Novel Spatiotemporal Chaotic Model with Provable Security
Authors: Dong Youheng , Zhao Geng , Tse Chi K. , Ma Yingjie , Ning Hao 
Published: May 2023

Abstract
In the application of chaos in cryptography, two questions remain unanswered: Does the chaos-based cipher possess provable security? Can the reproduction of a chaotic model or chaotic sequence be specified as a non-deterministic polynomial complete(NPC) problem or non-deterministic polynomial hard(NPH) problem for cryptanalysts? This paper proposes a spatiotemporal chaotic model called pseudo-random scrambling coupled map lattice (PRSCML) based on the coupled map lattice (CML) and the hybrid elementary cellular automata with a mask (HECA-M). This model can answer the above two questions affirmatively. The experiments reveal the strong chaotic properties of the PRSCML model, including the high Kolmogorov-Sinai entropy, randomness, and ergodicity. Furthermore, the sequences generated by PRSCML are backward and forward secure as the reproduction of a PRSCML model and its sequence are equivalent to the traveling salesman problem (TSP), which is an NPH problem. Meanwhile, the recurrence of a HECA-M belongs to the regular 3-SAT problem, which is an NPC problem. Therefore, the PRSCML model possesses provable security, and its superior performance demonstrates that it has great potential for cryptography. Moreover, this paper can reassure researchers that the security of some chaos-based ciphers can be confirmed for cryptography.
Evaluating the accuracy of ChatGPT in scientific writing
Authors: FERROUHI El Mehdi 
Published: May 2023

Abstract
This paper aims to assess the quality of ChatGPT’s answers when used to write a research paper and to explore its potential in assisting researchers in scientific writing. We made several requests to two versions of ChatGPT (3.5 and 4), with each one addressing a specific part of the research paper (Introduction, Literature Review, Data, and Code Implementation). The results indicate that ChatGPT could provide incorrect or even non-existent information for literature review, bibliographic references and data sources. Additionally, the results show that ChatGPT (3.5 and 4) require human assistance and verification of the accuracy of provided information after the fact. Also, this study confirms that ChatGPT-4 is more accurate than ChatGPT-3.5.
Therapeutic Challenges in Persistent Perceptual Postural Dizziness: Elections and Facts
Authors: Madrigal Jorge , Aguilar Catalina , Arbelaez-Lelion Daniela , Vanegas-Munera Johanna , Castillo-Bustamante Melissa 
Published: May 2023

Abstract
Postural perceptual persistent dizziness (PPPD) is a chronic vestibular disorder usually triggered by upright posture, active and passive movement, and exposition to visual or complex stimuli. Several strategies such as medications, vestibular rehabilitation and cognitive behavioral therapy have shown to be useful for symptoms relief, gaze stabilization and to diminish anxiety and depression. Herein, we performed a survey for healthcare providers to describe their therapy-based elections for PPPD,
ALT EKSTREMİTE KAS KUVVETİ, KALÇA EKLEM HAREKET AÇIKLIĞI VE SUBTALAR AÇININ DİNAMİK DENGE İLE İLİŞKİSİ
Authors: TOPAL Yusuf , KINIKLI Gizem İrem , BOZGEYİK Sibel , GUNEY DENİZ Hande 
Published: May 2023

Amaç: Sağlıklı bireylerde alt ekstremite kas kuvveti, kalça eklemi hareket açıklığı ve subtalar açının dinamik denge ile olan ilişkisini belirlemekti.
Yöntem: Çalışmamıza 69 sağlıklı ve gönüllü birey (yaş=22,17±1,25 yıl; 47 kadın, 22 erkek) dahil edildi. Bireylerin dinamik dengeleri Y denge testi (YDT), alt ekstremite kas kuvvetleri el dinamometresi, kalça eklem hareket açıklıkları ve subtalar açıları ise universal gonyometre ile değerlendirildi.
Sonuçlar: YDT ile alt ekstremite kas kuvvetleri ve kalça eksternal rotasyon hareket açıklıkları arasında pozitif anlamlı bir ilişki vardı (p
EFFECTIVENESS OF DIFFERENT PHYSICAL THERAPY EXERCISE TECHNIQUES IN CHRONIC LOW BACK PAIN: A RANDOMIZED CONTROLLED STUDY
Authors: AYTAR Ayça , ÇAĞLAR Aslıcan , TEKİNDAL Mustafa Agah , ÜMİT YEMİŞÇİ Oya , AYTAR Aydan 
Published: May 2023

Purpose: Exercise therapy is the most common conservative treatment for low back pain. Exercise has generally been associated pain and kinesiophobia. In this context, especially paraspinal muscles need to be focused on. For this reason, the aim of our study is to evaluate different types of exercises that will help increase neuromuscular facilitation and core stability in paraspinal muscles by considering patient satisfaction.
Methods: A total of thirty-seven female patients with chronic low back pain were included in the study. The Oswestry Low Back Pain Questionnaire was used to assess functionality. Core stability was evaluated with a stabilizer. Pain intensity and satisfaction were measured with Visual Analog Scale. Patients' kinesiophobia levels were assessed by using Tampa Kinesiophobia Scale. Patients were randomized into three groups according to the interventions as: Proprioceptive Neuromuscular Facilitation exercise group (n = 9), core stability exercise group (n = 14) and control (n = 14) group. The duration of applications was 3 days per week with a total of 6 weeks.
Results: There were group differences for core muscle strength (p = .045), Oswestry scores (p = .001), pain intensity score (p = .003) and Tampa score (p = .001). There were significant gains for Core muscle strength and Oswestry scores for Proprioceptive Neuromuscular Facilitation and Core stability groups (p < .05).
Conclusion. Core stabilization exercises have additional effects to improve rehabilitation outcomes for patients. Besides that, the level of patient satisfaction was importantly different between all groups in favor to Core stability in chronic low back pain.
Study of acidic air pollutant (SO2 and NO2) tolerance of microalgae with sodium bicarbonate as growth stimulant
Authors: Srivastava Saurabh , Omar Padam Jee , Shekhar Shiwanshu , Gupta Sneha 
Published: May 2023

Abstract
The major environmental toxicity of acidic pollutant in the fossil fuel gas substances has long been well known. Macro and microalgae are biological sources with a large range of biotechnological uses, for e.g., bioremediation, bio-fuel, air pollutant absorber, and many more. This study addresses the use of Chlamydomonas sp., an effective biomaterial in their tolerance against 2 and 5% of the SO2 & NO2. Growth kinetics were improved by the addition of sodium bicarbonate to the culture conical media. SO2 and NO2 were provided to culture media by the use of sodium meta-bisulfite and nitrous acid. The control combination of SO2 and NO2 provides: 2% SO2, 5% SO2, 2% NO2, 5% NO2, (2% SO2 + 2% NO2), (5% SO2 + 5% NO2) at the seventh day of incubation. The optimum pH ranged between 7.1 and 8.6 when exposed to gas. Results suggested that the growth kinetics of Chlamydomonas sp. is greater in SO2 and low in the 5% exposure of NO2. The maximum absorbing concentrations of SO2 and NO2 were 921.625 μg/ml and 906.25 μg/ml respectively for Chlamydomonas sp. This work highlights the potential of algae in tolerance to NO2 & SO2 from the polluted air.
Advances in Drug Therapy for Gastrointestinal Stromal Tumour
Authors: Liu Ju , Li Jiawei , Zhu Yan , Jing Rui , Ding Shi , Zhang Jifang , Zhao Leyan , Chen Ye , Shen Jiwei 
Published: May 2023

Introduction:
Gastrointestinal stromal tumour (GIST) is a common gastrointestinal
sarcoma located in the stromal cells of the digestive tract, and molecular studies
have revealed the pathogenesis of mutations in KIT and PDGFRA genes. Since imatinib
opened the era of targeted therapy for GIST, tyrosine kinase inhibitors (TKIs) that can
treat GIST have been developed successively. However, the lack of new drugs with satisfactory
therapeutic standards has made addressing resistance a significant challenge for
TKIs in the face of the resistance to first-line and second-line drugs. Therefore, we need
to find as many drugs and new treatments that block mutated genes as possible.

Methods:
We conducted a comprehensive collection of literature using databases, integrated
and analysed the selected literature based on keywords and the comprehensive nature
of the articles, and finally wrote articles based on the content of the studies.

Results:
In this article, we first briefly explained the relationship between GIST and KIT/
PDGFRα and then introduced the related drug treatment. The research progress of TKIs
was analyzed according to the resistance of the drugs.

Conclusion:
This article describes the research progress of some TKIs and briefly introduces
the currently approved TKIs and some drugs under investigation that may have better
therapeutic effects, hoping to provide clues to the research of new drugs.