bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Heavy metal concentrations in various tissues of two fish species from Damsa Dam Lake (Turkey) and associated health risk assessment
Authors: KAÇAR Emel 
Published: July 2023

Abstract
In current study, the distribution of 10 heavy metals in muscle, gills and liver of two fish species (Squalius pursakensis and Cyprinus carpio) living in the Damsa Dam Lake (Turkey) was examined in relation to fish gender and size. The highest quantities of all heavy metals were determined in the gills and liver of the fish species. The levels of most heavy metals in tissues did not differ significantly between both fish species. Only a few heavy metals in the tissues of both fish species demonstrated significant associations with fish length or weight. In terms of the levels of most of the heavy metals in the tissues, there weren’t any significant differences between the male and the female fish. The estimated daily intakes of all of the heavy metals were lower than the reference doses. The values of the target hazard quotient and the hazard index were found to be below 1 and the values regarding carcinogenic risk were assessed to be within or lower than the permissible levels. These results proved that the examined fish species can be consumed safely.
Ocena potencjału migracyjnego młodzieży z obszarów peryferyjnych Polski południowo - wschodniej
Authors: Cymanow Piotr , Florek-Paszkowska Anna 
Published: July 2023

W artykule opisano jeden z istotnych problemów związanych z migracjami zarobkowymi – zwłaszcza w odniesieniu do regionów peryferyjnych o znaczącym zapóźnieniu cywilizacyjnym, jakim jest zjawisko tzw. „drenażu mózgów” (brain drain). Problem ten dotyczy w głównej mierze absolwentów i osób młodych, które w obliczu rozpoczynania kariery zawodowej napotykają na istotne bariery polskiego rynku pracy. Przeanalizowano potencjalną skalę migracji wewnętrznych i zewnętrznych, oceniono rangę czynników determinujących wybór miejsca migracji oraz znaczenie elementów wpływających na charakter podejmowanej pracy z uwzględnieniem oczekiwań płacowych potencjalnych migrantów.
Bærekraftig utvikling: Hva er poenget?
Authors: Pilskog Ingjald , Heggen Marianne Presthus 
Published: July 2023

Education for sustainability builds on more than thirty years of experience in utilizing education to guide us to a better future, a future with a good life for all. In 1987, the World Commission on Environment and Development defined sustainable development as “development that meets the needs of the present without compromising the ability of future generations to meet their own needs” (Brundtland et al., 1987b, p. 41). We have interviewed six persons on their views of the concept “sustainable development,” opportunities and challenges they associate with the concept, and how education relates to them. Two of the informants represent the younger generation, two work with sustainability and environment in higher education, and the remaining two have been working with sustainability nationally and internationally for decades.
There is a consensus in international policy to use the concept of sustainable development as broadly as possible worldwide. To achieve an internationally united understanding between differing interests, the concept has gradually been expanded to include more perspectives. Such expansion may dilute the concept’s concrete content and weaken it as a result.
The immediate need for action to meet the challenges of the environmental and climate crises influences our informants’ view of the concept of sustainable development. They see sustainable development as a combination of interlinked and equally important ecological, economic, and social/cultural aspects. They emphasize the good intentions of the concept, but also underline its political and anthropocentric origin as a challenge to achieve the ambitions of the World Commission. We finalize the chapter by looking at how these perspectives influence education for sustainability.
ВИБІР МЕТОДУ КЛАСТЕРИЗАЦІЇ ДЛЯ ЗАДАЧІ НАВІГАЦІЇ КРОКУЮЧОГО РОБОТА У НЕСТРУКТУРОВАНИХ СЕРЕДОВИЩАХ
Authors: САЗОНОВ Артем , ЗГУРСЬКИЙ Данило , КУЧКІН Олексій 
Published: July 2023

Для нестандартних умов роботи роботів в більшості випадків можуть не підійти прості методи, що реалізовуються в пристроях для побутових потреб та тих, які використовуються в структурованому середовищу з дорогами, помітними перешкодами чи з певними мітками на які спирались би алгоритми виявлення перешкод та побудови маршруту. Якщо необхідно провести пошукові чи евакуаційні заходи, використовуючи крокуючих роботів, то це вже складні умови з певними особливостями. Головне завдання статті полягає у знаходженні такого методу кластеризації, який би показував гарні результати в неструктурованому середовищі з необхідною точність.
В роботі розглянуто загальновідомі методи кластеризації даних, що поділяються на чотири основні групи, які основані на різних шляхах обробки даних та розподілення їх на кластери. Наводяться основні поняття, на яких ґрунтуються принципи та алгоритми роботи методів. На аналізі переваги та недоліки обирається група методів, яка є найоптимальнішою для заданої задачі.
Експериментальне порівняння обраних методів проводиться на хмарах точок неструктурованих середовищ. Результати аналізуються на структуру виділених кластерів, виявлення шуму та швидкодію з урахуванням параметрів, що необхідні для роботи методу. Після аналізу якості кластеризації обирається метод з найкращими результатами для подальших досліджень. Для випробувань методу використовуються навісні, від’ємні та додатні перешкоди, такі як крони дерев, обрив та пагорби.
The efficiency of cognitive representation and its relationship to the development of historical investigation among students of the College of Education- Kirkuk University
Authors: عبدالرحمن فراس برهان الدين 
Published: July 2023

The current study aims to identify (the level of efficiency of cognitive representation and its relationship to the development of historical investigation among students of the College of Education) The study sample consisted of (200) students in the Department of History, College of Education, University of Kirkuk. To achieve the objectives of the study, the researcher prepared a scale for the study represented by (the cognitive representation scale), which included (25) items, and the researcher adopted the (historical investigation scale) prepared by Abdul Qadir (2018), which included seven groups and (35) items, and the researcher verified the validity of the two tools. and their reliability. By using the appropriate statistical means, the results were analyzed that showed:
1- There is a high level of cognitive representation of information among the students of the history department.
2- The level of possession by students of the history department of the historical investigation is good.
3- There is a positive effect and a clear relationship of the cognitive representation of information on students' development of historical investigation.
According to the results, the researcher came out with a number of recommendations, including enriching the curricula with content that depends on thinking skills and nourishing the mind by increasing activities and modern strategies, training students practically on acquiring information and generating ideas and investing their abilities to raise their cognitive efficiency, and the researcher suggested conducting a study on the level of cognitive representation and its relationship to acquisition Students creative thinking skills in history.
Vocabulary Learning Strategies Vis-a- Vis Vocabulary Teaching Strategies
Authors: Mohammed Abrar Kedir 
Published: July 2023

Learning a foreign language entails a learner to develop special effort or ways of learning to acquire the target language effectively. This can be achieved through using appropriate learning strategies. Thus, this article looks at the relationship between vocabulary teaching methods and vocabulary learning strategies employed by students and teachers in secondary schools. Mixed methods design was used to collect quantitative and qualitative data. Data were collected through questionnaire, interview and classroom observations. Separate analyses of the data were conducted, and the qualitative findings were used to support the numeric findings. The results showed that because teachers weren't always using them to teach vocabulary lessons, vocabulary teaching strategies were found to be less effective and practical in the sample schools. It also found that the students were unable to effectively use techniques for learning new word meanings and cementing them in their long-term memory. As a result, vocabulary teaching and learning methods have not received much attention from teachers and students. Thus, teachers should be given refreshment trainings on the teaching strategies of vocabulary so as to help students to make use of vocabulary learning strategies. Besides, it is suggested students’ training on how to use the strategies and promote the sense of autonomous learning..
Gut microbiome and serum short-chain fatty acids are associated with responses to chemo- or targeted therapies in Chinese patients with lung cancer
Authors: Chen Huan-Huan , Wu Qi-Jun , Zhang Tie-Ning , Zhao Yu-Hong 
Published: July 2023

BackgroundThe association between gut microbes and short-chain fatty acids (SCFAs) and therapeutic responses of patients with lung cancer (LC) receiving therapy remains unknown.MethodsFecal and serum samples were prospectively collected from patients with LC, classified as responders, if they presented durable clinical benefits, and non-responders, if not. The composition of gut microbes was analyzed using 16S ribosomal DNA sequencing. Serum SCFA concentrations were detected using gas chromatography. Cell proliferation, migration, invasion, cell cycle, and apoptosis assays were performed on isobutyric acid-treated A549 cells. Reverse transcription-quantitative PCR, Western blotting, immunocytochemistry, and immunofluorescence staining experiments have been performed to investigate the expression of associated genes or proteins.ResultsNon-responders harbored higher microbiome α-diversity but lower β-diversity compared with responders. Compared to the patients with low α-diversity, those with high α-diversity showed significantly shorter progression-free survival. Additionally, β-diversity has also been observed between these two groups. Specifically, Parasutterella, Clostridiaceae, and Prevotella_7 were more abundant among responders, whereas Bacteroides_stercoris and Christensenellaceae_R-7_group were more abundant in non-responders. The serum SCFA (especially acetate and isobutyrate) levels tended to be higher in responders. Isobutyric acid inhibited the proliferation, migration, and invasion of A549 cells by inducing apoptosis and G1/S arrest while upregulating the expression of GPR41, GPR43, and GPR5C and downregulating that of PAR1, and increasing the activity of histone acetyltransferases.ConclusionWe revealed the influence of gut microbiota and SCFAs on the therapeutic responses in patients with LC and the anti-tumor effect of isobutyric acid, indicating their potential use as therapeutic targets.
Novel computational and drug design strategies for inhibition of monkeypox virus and Babesia microti: molecular docking, molecular dynamic simulation and drug design approach by natural compounds
Authors: Akash Shopnil , Mir Showkat Ahmad , Mahmood Sajjat , Hossain Saddam , Islam Md. Rezaul , Mukerjee Nobendu , Nayak Binata , Nafidi Hiba-Allah , Bin Jardan Yousef A. , Mekonnen Amare , Bourhia Mohammed 
Published: July 2023

BackgroundThe alarming increase in tick-borne pathogens such as human Babesia microti is an existential threat to global public health. It is a protozoan parasitic infection transmitted by numerous species of the genus Babesia. Second, monkeypox has recently emerged as a public health crisis, and the virus has spread around the world in the post-COVID-19 period with a very rapid transmission rate. These two novel pathogens are a new concern for human health globally and have become a significant obstacle to the development of modern medicine and the economy of the whole world. Currently, there are no approved drugs for the treatment of this disease. So, this research gap encourages us to find a potential inhibitor from a natural source.Methods and materialsIn this study, a series of natural plant-based biomolecules were subjected to in-depth computational investigation to find the most potent inhibitors targeting major pathogenic proteins responsible for the diseases caused by these two pathogens.ResultsAmong them, most of the selected natural compounds are predicted to bind tightly to the targeted proteins that are crucial for the replication of these novel pathogens. Moreover, all the molecules have outstanding ADMET properties such as high aqueous solubility, a higher human gastrointestinal absorption rate, and a lack of any carcinogenic or hepatotoxic effects; most of them followed Lipinski’s rule. Finally, the stability of the compounds was determined by molecular dynamics simulations (MDs) for 100 ns. During MDs, we observed that the mentioned compounds have exceptional stability against selected pathogens.ConclusionThese advanced computational strategies reported that 11 lead compounds, including dieckol and amentoflavone, exhibited high potency, excellent drug-like properties, and no toxicity. These compounds demonstrated strong binding affinities to the target enzymes, especially dieckol, which displayed superior stability during molecular dynamics simulations. The MM/PBSA method confirmed the favorable binding energies of amentoflavone and dieckol. However, further in vitro and in vivo studies are necessary to validate their efficacy. Our research highlights the role of Dieckol and Amentoflavone as promising candidates for inhibiting both monkeypox and Babesia microti, demonstrating their multifaceted roles in the control of these pathogens.
Developing a recovery-oriented intervention for people with severe mental illness and an intellectual disability: design-oriented action research
Authors: Berger Ingeborg , Bruineberg Anne , van Ewijk Margot , de Jong Levi , van der Hout Michiel , van Weeghel Jaap , van der Meer Lisette 
Published: July 2023

IntroductionMild intellectual disability or borderline intellectual functioning (MID/BIF) are common in people with severe mental health problems (SMHP). Despite this, there is a lack of treatments adapted for this group of clients.MethodsThis qualitative study describes the development of a new intervention, guided by the principles of action research, for people with SMHP and MID/BIF and mental health professionals to help them talk about all aspects of the process of recovery. The intervention was developed in four cycles and in close cooperation with mental health professionals, experts by experience, other experts in the field of SMHP or MID/BIF, and clients. During all cycles there was a strong focus on the content of the intervention, exercises, understandable language, and drawings for visual support.ResultsThis resulted in the intervention “Routes to Recovery,” which covers both complaints and strengths, coping strategies, helpful (social) activities, and how to determine future steps in a recovery plan.DiscussionRoutes to Recovery is a first step in helping professionals and their clients with SMHP and MID/BIF to have a conversation about personal strengths and what the client needs to recover. Future research should investigate the effects of this intervention.
Análise do grau de conformidade legal dos dados de execução orçamentária nos portais de transparência municipais
Authors: Alves do Nascimento Vanessa , Souza Leal Ana Paula , De Sousa Almeida Bruno , Da Paixão Melo Jéssica , Sato de Souza Leonardo , Santos Saldanha Mateus , Scaravatti Paula 
Published: July 2023

O objetivo do artigo é analisar as plataformas de transparência das capitais brasileiras municipais com o intuito de verificar o grau de conformidade legal dos dados orçamentários desses portais, verificando se os dados obrigatórios e recomendados dispostos em legislação estão disponíveis. Para a análise, foi elaborado template de conformidade, verificando dados técnicos do site, itens de detalhamento de despesas e receitas, procedimentos licitatórios e informações financeiras publicadas, como Plano Plurianual, Lei de Diretrizes Orçamentárias, Balanços entre outros. Por fim, conforme análise desenvolvida, observou-se que a conformidade legal seguida pelos municípios para disponibilização de dados orçamentários é baixa, comprometendo o acesso da população às informações previstas em lei.
PENGARUH PREEKLAMPSIA TERHADAP KEJADIAN PERSALINAN PRETERM DI RSKDIA PERTIWI MAKASSAR TAHUN 2023
Authors: Rika  
Published: July 2023

Penelitian ini bertujuan untuk mengetahui apakah Preeklampsia mempengaruhi kejadian Persalinan Preterm di Rumah Sakit Ibu dan Anak Pertiwi Makassar tahun 2023.
Metode yang digunakan adalah penelitian medical record dengan pendekatan observasional case control.
Populasi penelitian ini adalah semua ibu yang bersalin di rumah sakit ibu dan anak pertiwi makassar sebanyak 426 orang. Dan Sampel sebanyak 300 dengan mengunakan tekhnik di rumah sakit ibu dan anak pertiwi makassar 2022 dengan sampel dalam penelitian ini secara Purposive Sampling.Analisis data dengan menggunakan uji chi squer
Hasil pengaruh preeklampsia (=0,5). Hal tersebut menunjukkan tidak ada hubungan antara preeklampsia dengan kejadian Persalinan Preterm. hasil penelitian yang dilakukan dapat ditarik kesimpulan bahwa Preeklampsia tidak ada pengaruh terhadap kejadian persalinan Preterm.Dari hasil penelitian ini disarankan Bagi para ibu yang berusia <20 tahun dan >35 tahun, paritas tinggi, dan ada riwayat penyakit lainya agar lebih memperhatikan kehamilannya untuk mencegah terjadinya hal-hal yang dapat berisiko dalam kehamilan dan persalinan.
Analysis of the Application of Emkm SAK in the Preparation of Financial Statements in the Sakti.Online Application
Authors: Hijjah Warnida , Kartini Tina , Indrawan Andri 
Published: July 2023

The purpose of this study is to analyze the application of SAK EMKM in the preparation of financial statements produced by the cooperative application system, namely SAKTI. Online. The research was conducted at the Nurul Iman Cooperative. This research uses qualitative methods with a type of comparative descriptive approach that will later describe, describe and compare theory and actual practice so that conclusions can be drawn. Data were obtained using observation, interview, and documentation techniques. The results of the study concluded that the financial statements of the Nurul Iman Cooperative were presented using the SAKTI.Online Applications were not by SAK EMKM completely because they had not presented the three components of financial statements according to SAK EMKM. The preparation of the Nurul Iman Cooperative financial statements was presented using the SAKTI.Online application only presents the balance sheet (statement of financial position), and the calculation report of operating results (income statement) but has not presented notes to the financial statements.
الوضع الراهن لاستخدام المبيدات الكيميائية على محاصيل الخضر المزروعة في البيوت المحمية في ضواحي مدينة البيضاء
Authors: عامر عبدالكريم 
Published: July 2023

في دراسة ميدانية (2007/2008) تم جمع معلومات هامة عن واقع استخدام المبيدات الكيميائية في مكافحة أفات الخضر المزروعة في البيوت المحمية في ضواحي مدينة البيضاء، حيث تم جمع البيانات باستخدام نموذج استبيان معد لهذا الغرض وحققت المعلومات الواردة وفق منهجية محددة مسبقاً. بين تحليل البيانات الواردة إن أنواع البيوت المحمية المنتشرة في منطقة الدراسة هي البيوت البلاستيكية والبيوت الزجاجية، ووجد إن هناك خمسة أنواع من الخضر مزروعة بنسب متفاوتة في هذه البيوت وهي (الخيار 46.15% ؛ الكوسة 23.07% ؛ الطماطم 15.38% ؛ الفلفل الحلو 7.69%؛ الفلفل الحار7.69% ) حيث توجد عدة أصناف من كل نوع. كما وجد إن هناك 12 نوع من مبيدات الآفات الكيميائية تستخدم خلال الموسم في البيوت المحمية التي شملتها الدراسة وهذه المبيدات هي (أومايت 57 ؛ بنليت ؛ دانيتول10 ؛ أجروميك ؛ ريملتو ؛ كوبرافيت ؛ مانكوزيب ؛ ريملتو 50 ؛ ريمليتين WP؛ دايثين W45 ؛ فايدان ؛ كبروكسيد )، وعند دراسة مدى تعرض كل نوع من محاصيل الخضر المزروعة للرش تبين إن محصول الخيار قد تحصل على نسبة 53.85% من حالات الرش المسجلة ، يليه محصول الكوسة بنسبة 23.07% ، ثم الطماطم بنسبة 15.38% والفلفل الحار 7.69% أما الفلفل الحلو فلم تسجل عليه أي حالة من حالات الرش المدروسة. وعند دراسة توزيع المبيدات المستخدمة في البيوت المحمية حسب نوع الآفات كان عكس التوقعات حيث شكلت المبيدات الفطرية نسبة 75 % من إجمالي المبيدات المستخدمة في حين حصلت مبيدات العناكب على نسبة 25% الباقية أما المبيدات الحشرية فقد كانت نسبة استخدامها 0% وكذالك مبيدات الحشائش. وبحساب الزمن بين كل رشة وأخرى تبين انه يتراوح من 1 إلى 30 يوم’ ايضاً حسبت المدة المحصورة بين الرش وتسويق المحصول حيث تبين إنها تتراوح من 3 – 21 يوم بمتوسط 8.38 يوم .
The influence of phase morphology of polycarbonate/polyethersulfone blends on the failure behavior between the blends and polyurethane in the peel test
Authors: Schneider Konrad , Bräuer Matthias , Bobeth Manfred , Kühnert Ines , Malanin Mikhail , Schlenstedt Kornelia , Pompe Wolfgang 
Published: July 2023

AbstractIn peel, tests between polycarbonate/polyethersulfone (PC/PES) blends with different compositions and thermoplastic polyurethane (TPU) films with different thicknesses a large decrease in energy release rate is observed when the PC/PES blends formed a co‐continuous structure. With SEM analysis, XRD measurements, selective PC etching of failed samples, and finite element modeling of the stress distributions in the co‐continuous region this fracture behavior can be explained. It is caused by the interplay between the formation of the main crack in the process zone and the size and density of microcracks in the energy dissipation zone. While the pure components PC and PES exhibit good adhesion to the TPU, the immiscibility of PC and PES causes the steady decrease of with increasing volume fraction of the minor phase.
Cytotoxic and Anti‐Inflammatory Activity of 3,19‐Isopropylidene‐/Arylidene‐Andrographolide Analogs
Authors: Van Chien Tran , Van Loc Tran , The Anh Nguyen , Van Sung Tran , Phuong Thao Tran Thi 
Published: July 2023

AbstractA series of 3,19‐isopropylidene‐/or arylidene‐andrographolide analogs were synthesized and their structures were confirmed by NMR spectroscopic methodology. Twenty‐five analogs were evaluated for theirin vitrocytotoxic activity against HT‐29, HepG2 and LNCaP cancer cell lines based on the sulforhodamine B (SRB) assay. Analog2 fexhibited the most potent cytotoxic activity, with IC50values of 11.14 and 9.25 μM on HepG2 and LNCaP cancer cell lines, respectively. Esterification of hydroxy functional group at position C‐14 in andrographolide analogs,2 aand2 b,showed somewhat higher cytotoxicity than the precursor. In addition, andrographolide analogs (2 a–2 d,2 f,3 a,4 aand4 h) were evaluated for the NO inhibitory activity in the LPS stimulated RAW264.7 macrophages. The most active analog2 asignificantly reduced nitric oxide (NO) production from LPS stimulated RAW264.7 cells, with IC50values of 0.34±0.02 μM providing encouraging results for anti‐inflammatory compound development.
Creating Hydrophobic Foils From Biopolymer Blends Using Mechanical Microimprinting
Authors: Liu Hang , Zagler Michaela , Nase Michael , Weber Katharina , Albrecht Joachim 
Published: July 2023

AbstractThe surface topography of biodegradable polymer foils is modified by mechanical imprinting on a submillimeter length scale. The created patterns strongly influence the wetting behavior and allow the preparation of hydrophobic surfaces with controlled solid‐liquid interaction. A detailed analysis of anisotropic surface patterns reveals that the observed effect arises from a combination of topographical and compositional changes that are introduced to the surface. As a main result it is found that an individual combination of material and structure is required for the production of water‐repellent biopolymer foils that are highly attractive for packaging applications.