bluuebunny/crossref_metadata_2025_split huggingface dataset:
A possible origin of the lunar spinel-bearing lithologies as told by the meteorite NWA 13191
Authors: Xie Lan F. , Chen Hong Y. , Miao Bing K. , Song Wen L. , Xia Zhi P. , Zhang Chuan T. , Chen Guo Z. , Zhang Jin Y. , Zhao Si Z. , Gao Xu K. 
Published: April 2023

Abstract
Pink spinel anorthosite (PSA) and pink spinel troctolite (PST) are two lunar lithologies known to contain Mg-rich spinel. PSA rich in spinel and lacking mafic minerals, was detected by the visible and near-infrared reflectance spectroscopy. PST clasts were found in returned lunar samples and meteorites. NWA 13191 is a recently approved lunar meteorite that contains a large amount of spinel-bearing clasts and provides an opportunity to discuss its origin. Sixty-four spinel-bearing clasts were studied in this research. These clasts are dominated by anorthitic feldspars (20.8–80.9 vol%, An90.9–96.8), mafic-rich and aluminum-rich glass (14.7–72.1 vol%) quenched from a melt, and spinels (0.19–5.18 vol%). Forty-nine of these clasts appear to have unusually low modal abundances of mafic silicates (avg. olivine ± pyroxene, 1.87 vol%), which distinguishes them from known spinel-bearing lunar samples (e.g., PST). The spinel compositions (avg. Mg# = 90.6, Al# = 97.4) and mafic minerals contents are basically consistent with those of PSA. The absorption characteristics of glass in the reflection spectrum are not obvious, so it is not clear if the PSA contains melt. The simulated crystallization experiment clearly shows that it contains a large amount of melt at the spinel crystallization stage. These phenomena provide experimental and sample evidence for the existence of glass in the lunar spinel-bearing lithologies. NWA 13191 records the highest known bulk Mg# (avg. 89.8), and the spinel records the highest Al# (98.8) and Mg# (93.1) of lunar samples to date. The chemical properties of spinel-bearing clasts in NWA 13191 are consistent with the slightly REE-enriched and alkali-poor Mg-suite rocks, such as PST, magnesian anorthosites (MANs), and olivine-enriched Mg-suite rocks. These phenomena and previous simulated crystallization experiments indicate that a Mg-Al-rich melt may be produced by impact melting of Mg-rich anorthosite precursors. The spinel is a metastable crystallization product along with plagioclase and vitric melt near the Moon’s surface. This realization provides observational evidence for previous simulated crystallization experiments and theoretical speculations.
Thermal conductivity of aluminous garnets in Earth’s deep interior
Authors: Hung Yu-Ping Grace , Tsao Yi-Chi , Lin Chun-Hung , Hsieh Wen-Pin 
Published: April 2023

Abstract
Aluminous garnets [(Mg,Fe,Ca)3Al2(SiO4)3] are a key mineral group in Earth’s interior. Their thermal conductivity with relevant chemical compositions and at high-pressure-temperature (P-T) conditions plays a crucial role in affecting the thermal states of pyrolytic mantle and subducted basaltic crust over the depth range they are present. Using ultrafast optical pump-probe spectroscopy combined with an externally-heated diamond-anvil cell, we have precisely determined the high-P-T thermal conductivity of aluminous garnets, including pyrope, grossular, and pyrope-almandine solid solution. We find that the variable chemical composition has minor effects on the thermal conductivity of these garnets over the P-T range studied. Combined with previous results, we provide new depth-dependent thermal conductivity profiles for a pyrolytic mantle and a subducted basaltic crust. These results significantly benefit geodynamics simulations and advance our understanding of the thermal structure and evolution dynamics in Earth’s upper mantle and transition zone. In addition, as garnets are also a key, useful material family for modern technology, our results on the thermal property of natural garnets also shed light on the novel design of optical and electronic devices based on various synthetic nonsilicate garnets.
Synovial sarcoma of the median nerve of the right shoulder (case report)
Authors: Khestanov D. B. , Efimova M. M. , Romantsova O. M. , Khairullova V. V. , Malakhova A. A. , Mikhailova E. V. , Dzampaev A. Z. , Varfolomeeva S. R. 
Published: April 2023

Synovial sarcoma (SS) is a soft tissue tumor that occurs among a group of tumors other than rhabdomyosarcoma (RMS) in childhood and adolescence in 4 % of cases. In terms of incidence among children, SS is second only to RMS and most often occurs in young and mature patients (15–35 years), with a slight predominance in men. The localization of SS in the soft tissues of the extremities reaches 80 %; to a lesser extent, these tumors occur in the head and neck, trunk, retroperitoneal space, and joints (no more than 5 %). Cases of the appearance of SS in the mediastinum, peripheral nerves, skin and visceral organs are also described.This article presents a rare clinical case of the development of SS of the median nerve of the right shoulder in a 15-year-old patient.
iCHECK-DH: Guidelines and Checklist for the Reporting on Digital Health Implementations
Authors: Perrin Franck Caroline , Babington-Ashaye Awa , Dietrich Damien , Bediang Georges , Veltsos Philippe , Gupta Pramendra Prasad , Juech Claudia , Kadam Rigveda , Collin Maxime , Setian Lucy , Serrano Pons Jordi , Kwankam S Yunkap , Garrette Béatrice , Barbe Solenne , Bagayoko Cheick Oumar , Mehl Garrett , Lovis Christian , Geissbuhler Antoine 
Published: April 2023

Background
Implementation of digital health technologies has grown rapidly, but many remain limited to pilot studies due to challenges, such as a lack of evidence or barriers to implementation. Overcoming these challenges requires learning from previous implementations and systematically documenting implementation processes to better understand the real-world impact of a technology and identify effective strategies for future implementation.

Objective
A group of global experts, facilitated by the Geneva Digital Health Hub, developed the Guidelines and Checklist for the Reporting on Digital Health Implementations (iCHECK-DH, pronounced “I checked”) to improve the completeness of reporting on digital health implementations.

Methods
A guideline development group was convened to define key considerations and criteria for reporting on digital health implementations. To ensure the practicality and effectiveness of the checklist, it was pilot-tested by applying it to several real-world digital health implementations, and adjustments were made based on the feedback received. The guiding principle for the development of iCHECK-DH was to identify the minimum set of information needed to comprehensively define a digital health implementation, to support the identification of key factors for success and failure, and to enable others to replicate it in different settings.

Results
The result was a 20-item checklist with detailed explanations and examples in this paper. The authors anticipate that widespread adoption will standardize the quality of reporting and, indirectly, improve implementation standards and best practices.

Conclusions
Guidelines for reporting on digital health implementations are important to ensure the accuracy, completeness, and consistency of reported information. This allows for meaningful comparison and evaluation of results, transparency, and accountability and informs stakeholder decision-making. i-CHECK-DH facilitates standardization of the way information is collected and reported, improving systematic documentation and knowledge transfer that can lead to the development of more effective digital health interventions and better health outcomes.
A Systematic Review of Piperine as a Bioavailability Enhancer
Authors: Chaudhri Sanjiv Kumar , Jain Sourabh 
Published: April 2023

Drug oral absorption is a crucial concern, particularly when the medication is costly, poorly bioavailable, and administered for extended periods of time. Chemical substances known as "bioenhancers" are those that, when combined with pharmaceuticals, increase their bioavailability without having a synergistic impact on the drug itself. Toxicity, expense, poor bioavailability, and long-term medication administration all contribute to the need for bioenhancers, which aid in solving the majority of these issues. Piperine, also known as 1-peperoyl piperidine, is an aromatic alkaloid produced by the Piper species. Piperine alters the lipid milieu and membrane dynamics at the site of absorption to improve permeability. The molecular nature of piperine makes it appropriate for inhibiting enzymes. By blocking several metabolising enzymes, it increases the bioavailability of many medications, including carbamazepine, curcumin, ciprofloxacin, ampicillin, metronidazole, oxytetracycline, and many more. As a result, piperine, a potent inhibitor of medication metabolism, effectively increases absorption. The mechanism, metabolic inhibition, influence of structural alterations on activity, and medications that are bioenhanced by piperine are all explored in the review that follows. It offers insight into the use of piperine as a useful bioenhancer and the advantages of a bioenhanced drug formulation over one without one. Bioavailability enhancers are typically plant-based molecules that support the biological activity, bioavailability, or uptake of drugs in combination therapy. This review article finishes with discussing piperine's capacity to increase bioavailability.
Keywords: Bioenhancers, Piperine, Oral absorption, Alkaloid.
Lipid-Polymer Hybrid Nanoparticles for Topical Drug Delivery System
Authors: Miri Veena , Jangde Rajendra Kumar , Singh Deependra , Suresh Preeti K. 
Published: April 2023

Human skin not only functions as a permeation barrier (mainly due to the stratum corneum layer), but also provides a unique delivery pathway for therapeutic and other active agents. These compounds penetrate via intercellular, intracellular and transappendageal routes, resulting in topical delivery (into skin strata) and transdermal delivery (to subcutaneous tissues and into the systemic circulation). Lipid–polymer hybrid nanoparticles (LPHNPs) are next-generation core–shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous. Recently, a fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids. Owing to its two-in-one structure, this approach is of particular interest as a combinatorial drug delivery platform in oncology. In particular, the outer surface can be decorated in multifarious ways for active targeting of anticancer therapy, delivery of DNA or RNA materials, and use as a diagnostic imaging agent.
Keywords: Lipid–polymer hybrid nanoparticle, Topical delivery, Drug delivery, Gene delivery.
Effect of Exposure to Soot on Activities of Alanine Transaminase, Gamma Glutamyl Transferase and Lipase among Cooks in Nnewi
Authors: Ihim Augustine Chinedu , Habeeb Yusuf , Manafa Patrick Onochie , Nwobodo Emmanuel Ikechukwu , Edward Ukamaka Chima , Obi Patrick Chinedu 
Published: April 2023

Exposure to soot can lead to hepatic and pancreatic dysfunction. This study determined serum alanine transaminase (ALT), gamma-glutamyl transferase (GGT), and triacylglycerol lipase activities of cooks exposed to soot. Thirty (30) participants (cooks) were exposed to soot (test group), and thirty (30) participants not exposed to soot (control group) were recruited. Ethical approval was obtained from the Ethics committee of the Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, and informed consent from the participants was obtained. Alanine transaminase, gamma-glutamyl transferase, and triacylglycerol lipase activities were determined using the spectrophotometric method while the Body mass index (BMI) was calculated using weight (kg)/height2 (m2). An Independent t-test was used for statistical analysis. The results showed that the mean serum activities of alanine transaminase (14.69±1.84), of cooks exposed to soot, were significantly higher compared with the control(12.83±0.94)(p<0.05). The mean serum activities of gamma-glutamyl transferase (7.81±4.08), of cooks exposed to soot, were significantly higher when compared with the control (3.54±2.00)(p<0.05). The mean serum activities of triacylglycerol lipase of cooks exposed to soot were significantly low compared with the control (p<0.05), while there was no significant difference in the BMI, systolic pressure, and diastolic pressure levels respectively in the test group, compared to the control. This study observed higher serum activities of alanine transaminase, gamma-glutamyl transferase, and low serum activity of triacylglycerol lipase among cooks exposed to soot, this suggests a predisposition to hepatic and pancreatic dysfunction in the cooks
Keywords: Soot, alanine transaminase, gamma-glutamyl transferase, lipase enzymes
A Systemic review on Antioxidant Potential of Berries used in Imuuxanth by Renatus
Authors: Dutta Rajdeep Dutta Gopal , Kar Gautam , Shukla Surya Prakash 
Published: April 2023

Food items which are plant based such as Berries, Vegetables and Fruit have significant effects on health, they pertain potential to boost up immune system. There have been researches and documents journaled supporting roles of phytochemicals extricated from berries in modulation of immune system. The primary phytochemicals in berry fruits are phenolic composites including flavonoids (anthocyanins, flavonols, flavones, flavanols, flavanones, and isoflavonoids), tannins, and phenolic acids. The presence of unequivocal Amount of polyphenols makes berries active against oxidative stresses (Antioxidant) and inflammation (Anti-inflammatory) in reverberations these berries show therapeutics such as Antidiabetics, Anticancerous, Anti-neurological muddles. This review examines berries which were used in imuuxanth formulation developed by Renatus Wellness: blackberries, blackcurrants, blueberries, cranberries, raspberries, black raspberries, and strawberries and their polyphenols having antioxidant potential Nevertheless, future clinical trials are required to study and improve the bioavailability of berries’ phenolic compounds and extend the evidence that the active compounds of berries can be used as medicinal foods against various diseases.
Keywords: Antioxidant, Berries, Imuuxanth, Renatus
Diuretic effects and subacute toxicity of Trema orientalis Linn leave extract in wistar rats
Authors: Tokou Labite Kpoti , Togbenou Komlatsè , Dosseh Kossivi , Idoh Kokou , Kpatcha Tchazou , Agbonon Amégnona 
Published: April 2023

Trema Orientalis is a medicinal plant used in the treatment of cardiovascular diseases including hypertension. The present study was undertaken to investigate phytochemical compounds, diuretic activity and subacute toxicity of the hydromethanolic leaf extracts of Trema orientalis. Phytochemical analysis carried out through color and precipitation reactions revealed the presence of many metabolites. The measurement of diuretic activity carried out by saline overload with 0.9% NaCl at a dose of 50 mL/kg in wistar rats showed that the hydromethanolic extract of Trema orientalis leaves had diuretic activity at a dose of 200 mg/kg of body weight. However, this diuretic activity was relatively low compared to the action of the reference molecule, furosemide. The study of the subacute toxicity of the extract took place over 28 days. No significant difference was recorded in the body weights during the 28 days of the study. Likewise, the weight of the organs collected after sacrifice of the rats and their macroscopic aspects did not show any significant difference with those of the control group. The extract increased the count of white and red blood cells as wells as platelets, practically at the two doses used and caused a decrease in ALT at the dose of 500 mg/kg. The extract could have a beneficial effect like a boosting immunity and would not present any toxicity at these doses.
Keywords: phytochemical, diuretic, subacute toxicity, Trema orientalis
Osmotic stress induced alterations in fatty acid composition and other metabolic responses in seedlings of Sinapis alba
Authors: Mitra Souvik , Begum Afsana 
Published: April 2023

Sinapis alba L. (white mustard), an annual member of Brassicaceae, is an important oilseed crop with significant agronomic traits including tolerance to abiotic stress. The present study was aimed to assess the changes in biochemical attributes of S. alba, mainly the composition of lipids and fatty acids, in response to osmotic stress. Seedlings were subjected to stress condition by growing them on media supplemented with three different concentrations of polyethylene glycol (PEG 6000) solutions, respectively with ‑0.04, ‑0.16 and ‑0.64 MPa osmotic potential. Compatible solute content, lipid content, and lipid peroxidation of the seedlings were measured. Total fatty acid composition was analysed by gas chromatography mass spectrometry. Overall negative impact of PEG-mediated osmotic stress was apparent from seedling morphology. Total lipid content decreased in stressed plants together with increased level of triacylglycerol. Increase of lipid peroxidation in stressed condition indicated suppression of membrane integrity. The key outcome was the significant increase of unsaturation level of fatty acids due to higher accumulation of linoleic acid, α-linolenic acid and erucic acid in the seedlings exposed to higher osmotic stress. The results indicate that, in white mustard, the biochemical changes induced by osmotic stress mainly depend on changes in lipid composition and fatty acid unsaturation level, which maintain membrane stability during the early stage of seedling development.
Análisis de los principales riesgos laborales en trapiches comunitarios del Corregimiento de San Bernardo Municipio de Ibagué
Authors: Casanova Ortiz Edwin Eliecer 
Published: April 2023

According to FEDEPANELA, the national panela agroindustry generates livelihoods for around 350,000 family groups in the country. According to the Ministry of Agriculture and Rural Development, the cultivation of sugarcane for the production of panela in 2018 is 1,612,282 tons, cultivated on 367,251 hectares nationwide. In general, the largest production of panela is carried out on small farms through artisanal processes in which a high intensity of family work prevails and very low rates of technology introduction.
From Occupational Health and Safety as a science, significant effects can be found in terms of occupational risks in the activity, the objective of the project is to analyze the main ergonomic impacts in the sugar mills. Previous studies have already concluded about the serious repercussions for the worker due to musculoskeletal injuries and the possible development of occupational diseases derived from poor ergonomic handling.

The study will be carried out in a sugar mill located on the outskirts of the municipality of Ibagué and will allow characterizing the biomechanical risk factors related to Strength and Biomechanics, Load Management, Postural Loads and repetitiveness in the tasks of said productive units; The diagnosis resulting from the research can help improve the way tasks are carried out, design more suitable jobs, propose the development of ergonomic devices, improve productivity, optimize times and help a rural population dedicated to this work. much healthier..
Procesamiento y análisis de señales electrocardiográficas (ECG)
Authors: Martínez Toro Ivonne Nataly , Mateus Abaunza Paola Andrea 
Published: April 2023

For the detection of cardiovascular disorders known as arrhythmias, an algorithm is designed for analyzing electrocardiographic signals in Matlab that enables the preprocessing of information provided from the 'PTB Diagnostic ECG Database v1.0.0', which is free for use on the PhysioNet site.

First, information is restricted only to reading the V3 and V4 ventricles, which provides information related to myocardial problems. The use of the Gabor Wavelet transform can corroborate the data of the spectrum in frequency, visualizing the scalograms of each ventricle. Afterwards, a band-pass filter (FPB) is applied to delete the data acquired by the electrocardiogram, known as the baseline or isoelectric line.

Finally, the addition of the Pan-Tompkins algorithm allows the detection of QRS complexes, which are studied to depict ventricular depolarization or electrical stimulation.
Metodología SCRUM para el diseño de los videojuegos serios - TUTELAGANAS
Authors: Saza Garzón Ilber Dario , Pérez Cotes José Mario , Gorrón Néstor Fabian , Reina Javier Gerardo , García Villa Jaime José , Páez Quintero Johanna Carolina , Para Elliot 
Published: April 2023

This document exposes the experience of inter-school research between the school of legal sciences and the multimedia chain, where it is intended to support learning exercises on the issue of compliance with rights through the management and processing of the guardianship action. for students of legal sciences, therefore, it is necessary to create academic spaces based on real situations to achieve significant learning in students, so from technological innovation initiatives it is postulated to make a video game that allows creating real scenarios, motivations that They allow users to learn about the guardianship action and provide solutions to problems typical of the Colombian context. Thus, this proposal is a mixed-type investigation where qualitative and quantitative data converge to identify the effectiveness and usability of the possible video game, in addition to the fact that this technological resource facilitates the learning processes through extrinsic motivation and play.
Arquitecturas de nano-redes de comunicaciones en el internet de las nano-cosas IONT
Authors: Tapias Baena Juan Esteban , Flor Paulita , Parra Hector 
Published: April 2023

Nanotechnology provides solutions to different problems, such as biomedical, industrial, agricultural and military fields. So, nano-networks are used for nano-scale communication between different nano-devices in the different Nano-Network architectures. But when a nano-network is connected to the Internet, it becomes a new paradigm called the Internet of Nano-Things.

Therefore, the objective of this article is to analyze the most important concepts of nano-networks, applications and projects. IoNT architectures based on the proposals of Akyildiz and Jornet, the complementary security architecture by Sicari, Rizzardi, Piro, Coen-Porosini and Grieco and the nano- network architecture proposed by Akram Galal and Xavier Hesselbach will be reviewed. Finally, technological trends at the IoNT level and the challenges in terms of security, privacy, communication and energy will be reviewed.
Diseño de un prototipo basado en IoT para la medición de residuos orgánicos aprovechables en unidades habitacionales
Authors: Pua Castro José Luis , Zabala Calderón Sharee Valentina , Rodriguez Aya Angel Alejandro , Polanco Ramiro Hernan 
Published: April 2023

This paper presents a beta prototype measurement to usable organic generate in housing units waste. This document shows a Hardware and a Software prototipes apply to IoT. The prototype measurement was developed with an Arduino Nano Card and an ESP-01 that can mass measure in grams (g) and then sending the information at defined time intervals over a 2.4Ghz Wi-Fi network to the ThingSpeak platform. The preliminary results have errors under 1.4%, on the other hand it has a loss sending percentage information under than 2% between the prototype and ThingSpeak.