bluuebunny/crossref_metadata_2025_split huggingface dataset:
Classification of Hamiltonian Non-Abelian Painlevé Type Systems
Authors: Bobrova Irina , Sokolov Vladimir 
Published: December 2022

AbstractAll Hamiltonian non-abelian Painlevé systems of $${{\,\mathrm{P_{1}}\,}}-{{\,\mathrm{P_{6}}\,}}$$

P
1

-

P
6

type with constant coefficients are found. For $${{\,\mathrm{P_{1}}\,}}-{{\,\mathrm{P_{5}}\,}}$$

P
1

-

P
5

systems, we replace an appropriate inessential constant parameter with a non-abelian constant. To prove the integrability of new $${{\,\mathrm{P_{3}^{\prime }}\,}}$$

P

3

′

and $${{\,\mathrm{P_{5}}\,}}$$

P
5

systems thus obtained, we find isomonodromic Lax pairs for them.
Evaluating the feasibility and acceptability of the Mood Assessment Post-Stroke (MAPS) mood screening training
Authors: El-Helou Rebecca , Rogers Jeffrey M. , Ryan Brooke , Marsden Dianne L. , Winkler Ann , Baillie Andrew , Kneebone Ian 
Published: December 2022

AbstractMood problems are common after stroke, and screening is recommended. Training may support staff knowledge and implementation of screening, but the feasibility of training programmes in the Australian healthcare system has not been formally established. This study aimed to assess the feasibility of a mood screening training for a multidisciplinary team (MDT) of stroke clinicians working in a post-acute inpatient rehabilitation service.Twelve staff from a rehabilitation service at a major hospital in Sydney, Australia participated in a 3-h interactive training session. The feasibility of running the course, assessment of knowledge gained via a consolidation exercise and quiz and acceptability of the training were assessed via focus groups.The in-person modality of the training hindered recruitment and assessment of participants’ knowledge, though the actual measures themselves appeared appropriate. Nine participants provided feedback in two focus groups. Thematic analysis identified positive reactions to the training. However, low self-efficacy persisted and organisational/socio-cultural barriers to implementation emerged. Following training, the medical officers of the MDT had successfully implemented routine screening.Overall, the training appeared acceptable and to foster knowledge in staff. However, limitations to recruitment and administering evaluations were identified. The development of flexible online training may improve future evaluations of screening training programmes/pathways.
Toward data assimilation of ship-induced aerosol–cloud interactions
Authors: Patel Lekha , Shand Lyndsay 
Published: December 2022

Abstract
Satellite imagery can detect temporary cloud trails or ship tracks formed from aerosols emitted from large ships traversing our oceans, a phenomenon that global climate models cannot directly reproduce. Ship tracks are observable examples of marine cloud brightening, a potential solar climate intervention that shows promise in helping combat climate change. In this paper, we demonstrate a simulation-based approach in learning the behavior of ship tracks based upon a novel stochastic emulation mechanism. Our method uses wind fields to determine the movement of aerosol–cloud tracks and uses a stochastic partial differential equation (SPDE) to model their persistence behavior. This SPDE incorporates both a drift and diffusion term which describes the movement of aerosol particles via wind and their diffusivity through the atmosphere, respectively. We first present our proposed approach with examples using simulated wind fields and ship paths. We then successfully demonstrate our tool by applying the approximate Bayesian computation method-sequential Monte Carlo for data assimilation.
Hospital-acquired bacterial infections in coronavirus disease 2019 (COVID-19) patients in Israel
Authors: Schwaber Mitchell J. , Temkin Elizabeth , Lobl Rona , Schechner Vered , Nutman Amir , Carmeli Yehuda 
Published: December 2022

AbstractBackground:We sought to determine incidence of common hospital-acquired bacteria among coronavirus disease 2019 (COVID-19) patients in Israeli general hospitals during the first year of the pandemic.Methods:We analyzed routinely collected incidence data to determine hospital acquisition of the following sentinel bacteria: Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Pseudomonas aeruginosa, Acinetobacter baumannii, and Clostridioides difficile. We examined 3 acquisition measures: (1) sentinel bacteria, (2) sentinel bacteremia, and (3) antimicrobial-resistant sentinel bacteremia. The study period was March 1, 2020, through January 31, 2021.Results:Analysis of pooled data from the 26 hospitals surveyed revealed that rates were higher for all 3 acquisition measures among COVID-19 patients than they were among patients on general medical wards in 2019, but lower than those among patients in intensive care units in 2019. The incidence rate was highest during the first COVID-19 wave, despite a lower proportion of severe COVID-19 cases among total hospitalized during this wave. Wide variation in incidence was evident between hospitals.Conclusions:Hospitalized COVID-19 patients experienced nosocomial bacterial infection at rates higher than those of patients on pre-pandemic general medical wards, adding to the complexity of their care. Lower rates of nosocomial infection after the first wave, despite higher proportions of severely ill patients, suggest that healthcare worker practices, rather than patient-related factors, were responsible for most of these infections.
The challenge of writing histories of ‘women’: the case of women and the law in late medieval Ireland
Authors: Booker Sparky 
Published: December 2022

AbstractCritiques of women's history based on intersectional analysis have demonstrated the importance of recognising differences between women and the perils of assuming commonality of experience based on gender. The idea that we can treat women as a group in some meaningful way is further complicated in medieval legal history by the fact that women's legal entitlements differed depending on their marital status. This paper examines women's experiences of the law in the English colony in late medieval Ireland. It argues that, despite the importance of ethnicity, social status and marital status in shaping different women's experiences of the law, gender played a significant role in their legal arguments and the ways in which juries and justices perceived them. Women's experiences at law were influenced in myriad ways by shared societal assumptions about their vulnerability and subordination to men. These assumptions influenced women regardless of the many social divisions and circumstances that made each woman unique. This study finds, therefore, that ‘women’ is a legitimate and productive category for historical research in the late medieval legal context but urges historians to interrogate more robustly why ‘women’ is an appropriate analytical category for their specific historical questions.
Developing an agenda for the history of women religious in Ireland: historiography and potentiality
Authors: Raftery Deirdre 
Published: December 2022

AbstractIn ‘An Agenda for women's history in Ireland, 1500–1900’ (1992), Margaret MacCurtain, Mary O'Dowd and Maria Luddy noted that research on convents and women religious (nuns/sisters) in Ireland was beginning to open up in the 1980s. They also suggested areas that merited the attention of scholars, including the experience of vowed religious life by women, issues of class and power within Irish convents, and the role of nuns in Irish society. This article examines historiographical developments, with a view to seeing whether or not scholars rose to the challenges posed in 1992. Additionally, it considers areas that still demand attention.
Exploring the ordinary: migration, sexuality and crime, and the progression of the ‘Agenda’ in Irish women's history, 1850s–1950s
Authors: Farrell Elaine , McCormick Leanne , Redmond Jennifer 
Published: December 2022

AbstractThis article reflects on some developments in women's history based on the 1992 ‘An agenda for women's history in Ireland, 1500–1900’, particularly responding to the section authored by Maria Luddy, incorporating work grounded in the nineteenth century up to the first half of the twentieth. Specifically, it considers developments in Irish women's social history over the past thirty years on the period from the 1850s to 1950s. The focus is on themes of poverty and migration, crime, and sexuality, which were touched on in the ‘Agenda’ and identified as areas for future research. Analysis on these subjects allows for an insight into lived realities for ‘ordinary’ women. These are areas which reveal the growth and development of historical research and its impact on public narratives and policy. Taking its cue from the ‘Agenda’, this article also identifies other fruitful research topics that could be further explored in future scholarship.
The textual terrain: developments and directions in women's writing, 1500–1700
Authors: Coolahan Marie-Louise 
Published: December 2022

AbstractThis article assesses our much-expanded view of the texts produced by early modern women in Ireland, surveying what is available to present-day researchers and considering emerging methodologies for the analysis of early modern female voices. The range of genres with which we now know early modern women engaged owes much to feminist literary historians’ capacious approach to defining literature, expanding beyond traditionally elite genres (drama, poetry, fiction) to encompass writing in all its forms. Thus, the present corpus includes letters and petitions, life writing, devotional prose, legal depositions, as well as all kinds of verse and song, in multiple languages. Moreover, where the primary evidence in Ireland sometimes seems sparse, international perspectives have illuminated the currents of women's writing. Interpretative paradigms from other fields — book history and the history of reading, culinary and medical history, network analysis — are being applied to yield fresh insights about this material. The question of how early modern Ireland was experienced by women has been explored in studies that address such texts as articulations of subjectivity, in the light of the history of emotions. The wide range of situations and genres of women's writing in early modern Ireland is now firmly evident, inspiring a host of new approaches.
Margaret MacCurtain (1929–2020): an appreciation
Authors: O'Dowd Mary 
Published: December 2022

‘Wisdom it was I loved and searched for her from my youth. I resolved to have her as my companion. I fell in love with her beauty ….’At the funeral mass for Margaret MacCurtain, her grandnephew, Michael, read the first reading from the Book of Wisdom, a moving and appropriate text with which to begin a celebration of Margaret's life. The words carried an added significance as Michael's reading emphasised that wisdom was represented in the biblical verse as female.
The effects of proposal power on incumbents' vote share: updated results from a naturally occurring experiment
Authors: Green Donald P. , Sevi Semra 
Published: December 2022

AbstractA pioneering study by Loewen et al. made use of the Canadian legislature's newly instituted lottery, which enabled non-cabinet Members of Parliament (MPs) to propose a bill or motion. Their study used this lottery in order to identify the causal effect of proposal power on incumbents' vote share in the next election. Analyzing the first two parliaments to use the lottery, Loewen et al. found that proposal power benefits incumbents, but only incumbents who belong to the governing party. Our study builds on these initial results by adding data from four subsequent parliaments. The pooled results no longer support the hypothesis that MPs—even those who belong to the governing party—benefit appreciably from proposal power. These updated findings resolve a theoretical puzzle noted by Loewen et al., as proposal power would not ordinarily be expected to confer electoral benefits in strong party systems, such as Canada's.
Correlated mechanochemical maps of Arabidopsis thaliana primary cell walls using atomic force microscope infrared spectroscopy
Authors: Bilkey Natasha , Li Huiyong , Borodinov Nikolay , Ievlev Anton V. , Ovchinnikova Olga S. , Dixit Ram , Foston Marcus 
Published: December 2022

Abstract
Spatial heterogeneity in composition and organisation of the primary cell wall affects the mechanics of cellular morphogenesis. However, directly correlating cell wall composition, organisation and mechanics has been challenging. To overcome this barrier, we applied atomic force microscopy coupled with infrared (AFM-IR) spectroscopy to generate spatially correlated maps of chemical and mechanical properties for paraformaldehyde-fixed, intact Arabidopsis thaliana epidermal cell walls. AFM-IR spectra were deconvoluted by non-negative matrix factorisation (NMF) into a linear combination of IR spectral factors representing sets of chemical groups comprising different cell wall components. This approach enables quantification of chemical composition from IR spectral signatures and visualisation of chemical heterogeneity at nanometer resolution. Cross-correlation analysis of the spatial distribution of NMFs and mechanical properties suggests that the carbohydrate composition of cell wall junctions correlates with increased local stiffness. Together, our work establishes new methodology to use AFM-IR for the mechanochemical analysis of intact plant primary cell walls.
The Muslim Students’ Society of Nigeria (MSSN) since 1954: education, Muslim–Christian encounters and regional variation
Authors: Balogun Adeyemi 
Published: December 2022

AbstractThe Muslim Students’ Society of Nigeria (MSSN) is a movement that promotes the Islamic identity of Muslims in Nigeria’s educational institutions. Despite promoting the same objectives around the country, a comparison of the MSSN’s activities between the northern and southern regions of Nigeria suggests that the success of the movement varies in many aspects. This is because there are two main types of regional variation relating to the MSSN: the success of Christian opposition to the MSSN’s objectives; and the attitude of many Muslims and the government to those objectives. For example, in the Muslim-dominated northern states, the call by the MSSN to let Muslim girls wear the hijab in schools and the MSSN’s support for the reintroduction of sharia were welcomed by the state governors. However, in the south-west region, where the populations of Muslims and Christians are roughly equal, the MSSN struggled to get the state governors to accept the hijab and the call for sharia was rejected. This article thus argues that, despite envisioning the same notion of Islam for all Muslim students in Nigeria, the MSSN’s activities do not produce a monolithic Islam, and that this reflects differences in the practice of the religion across the country.
OP03 Patient Characteristics Affect Their Treatment Choice: A Discrete Choice Experiment With Breast Cancer Patients In Six European Countries
Authors: Stamuli Eugena , Corry Sorcha , Foss Petter 
Published: December 2022

IntroductionThe evolution of breast cancer treatments over the last decade has resulted in tailored therapies for the different types and stages of breast cancer. Each treatment has a profile of benefits and adverse effects which are taken into consideration when planning a treatment pathway. The objective of this study is to examine whether patients’ preferences are in line with what is considered important from policy-makers viewpoint.MethodsAn online discrete choice experiment (DCE) was conducted in six European countries (France, Germany, Ireland, Poland, Spain, UK) with breast cancer (BC) patients. The DCE comprised of six attributes: overall survival (OS), hyperglycaemia, rash, pain, functional well-being (FWB) and out-of-pocket payment (OOP). Sixteen choice sets with two hypothetical treatments and a “no treatment” option were presented. Sociodemographic and disease related data were collected. Heteroscedastic conditional and mixed logistic models accounted for scale and preference heterogeneity between countries and patients respectively. Latent class analysis categorized patients in classes. Marginal rates of substitution (MRS) were estimated for OOP versus the rest of attributes to establish the ranking of preferences for each attribute.ResultsTwo hundred and forty-seven patients with advanced or metastatic BC and 314 with early-stage BC responded. Forty-nine percent of patients were less than 44 years old and 65 percent had completed university education. The MRS of the analysis demonstrated that “severe pain” is the highest dis-preferred attribute level, followed by “severe impairment in FWB” and OS. Four classes of patients as “decision-makers” were identified. Additionally, there is sensitivity in preferences for both levels of pain and FWB depending on the stage of the disease.ConclusionsThis study suggests that there is heterogeneity in treatment preferences of breast cancer patients depending on their sociodemographic and disease related characteristics. In combination with clinical guidelines, patient preferences can support the selection and tailoring of treatment options.
OP08 Early Access To New Direct-Acting Antiviral: A Journey On Introduction Of Ravidasvir For Hepatitis C Treatment In Malaysia
Authors: Idrus Nazatul Syima , Yusof Faridah Aryani Md , Lajis Rosliza 
Published: December 2022

IntroductionAccess to affordable direct-acting antiviral (DAA) remains limited in developing countries, often due to high treatment cost. This study aimed to elaborate the initiatives taken by the Ministry of Health Malaysia (MoHM) to provide early access to ravidasvir, a new DAA for hepatitis C treatment, in Malaysia.MethodsMoHM collaborated with Drugs for Neglected Diseases initiative (DNDi) to develop ravidasvir, a new chemical entity of oral non-structural protein 5A (NS5A) inhibitor. MoHM co-sponsored and participated the DNDi-led Phase II/III study (STORM-C-1 trial) to assess the efficacy and safety of ravidasvir-sofosbuvir combination therapy. Agreement was signed between Pharmaniaga, Pharco Pharmaceuticals and DNDi to register and supply affordable hepatitis C treatment in Malaysia and South-East Asia. MoHM and Pharmaniaga mutually worked on the registration of ravidasvir in Malaysia. Series of pre-submission meetings took place, rolling submission was allowed and conditional registration pathway was used. As a separate initiative, MoHM partnered with the Foundation for Innovative New Diagnostics (FIND) to implement decentralization and test-and-treat strategies for screening of hepatitis C virus (HCV).ResultsFirst stage of the STORM-C-1 trial reported that the combination of ravidasvir-sofosbuvir was highly effective across all genotypes and safe. The Drug Control Authority (DCA) Malaysia has granted a conditional registration for ravidasvir hydrochloride 200mg tablet (Ravida®) in June 2021, making Malaysia as the first country in the world to approve ravidasvir. Registration process expedited and took place within 15 months. The supply of Ravida® in Malaysia is expected in near future. Meanwhile, MoHM also implemented nationwide HCV screening using rapid diagnostic test kit in private hospitals, community clinics, prisons and rehabilitation centers which previously was done only in hospitals for outreach to the targeted group.ConclusionsRavidasvir-sofosbuvir has potential as a tool to eliminate hepatitis C in Malaysia by 2030, the WHO’s global elimination targets. This alternative new drug development model was successful due to strong leadership, public-private partnership and collaborative strategies. This could also be exercised in other disease area.
OP10 Outcomes Of Expanded Access To Transcatheter Aortic Valve Implantation In Ontario: A Model-Based Analysis
Authors: Miranda Rafael N , Peel John , Naimark David , Wijeysundera Harindra 
Published: December 2022

IntroductionTranscatheter aortic valve implantation (TAVI) is a minimally invasive therapy for patients with severe aortic stenosis. In Ontario, increases in capacity have not matched the rapidly growing demand for TAVI. As a result, wait-times for TAVI in Ontario exceed guideline targets, and waitlist morbidity is consequently considerable. The objective of this study was to evaluate the clinical implications of expanded TAVI capacity.MethodsWe performed a decision analysis using an open, parallel, resource-constrained microsimulation from the Ontario Ministry of Health perspective. Simulated patients entered the model during a five-year period, and stayed in the model until death or end of time horizon. Referral numbers increased annually according to historical trends. The additional capacity required to meet wait-time benchmarks in five years was identified by a sensitivity analysis. Clinical outcomes were estimated for three strategies: (i) current practice with annual capacity increases; (ii) accelerated capacity increases achieving benchmarks after five years; and (iii) no increase in capacity. Outcomes included pre-procedural mortality and hospitalization, and the proportion of TAVIs performed urgently.ResultsOver the five years, we estimated that TAVI referrals would increase from 1,980/year to 3,268/year. To achieve wait-time benchmarks during this period, TAVI rates must be increased by approximately 6.3 percent annually, for a total of 12,220 procedures performed over the 5 years. Compared to current TAVI capacity increase, an accelerated increase in capacity achieving wait-time benchmarks led to a reduction of 29.36 percent in pre-procedural deaths, as well as 26.38 percent in pre-procedural hospitalizations and 30.31 percent in nonelective TAVIs.ConclusionsIncreases in TAVI capacity in Ontario must be accelerated to meet wait-time benchmarks in five years. Expansion of TAVI care in Ontario would be associated with considerable reductions in mortality and hospitalizations. Without intervention, both wait-times and adverse outcomes on the waitlist are expected to continue increasing. Prioritization strategies to mitigate the adverse effects of long wait-times must be used until wait-time targets are achieved.