bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of α‐MnO2, β‐C2S, and α‐MnO2/β‐C2S nanocomposite for effective removal of phosphate from water
Authors: Rathore Roshni , Waghmare Aakash , Rai Sarita , Chandra Vimlesh 
Published: August 2023

AbstractA novel α‐manganese dioxide/β‐dicalcium silicate (α‐MnO2/β‐C2S) nanocomposite was synthesized for adsorption of phosphate ions from water to inhibit eutrophication. The adsorption rate constants (k2) of α‐MnO2/β‐C2S nanocomposite are higher than those of bare α‐MnO2 and β‐C2S revealing an increased adsorption rate in composite materials. The higher adsorption capacity of nanocomposites results from relatively larger pores. The phosphate sorption process obeys the pseudo‐second‐order kinetic model well and is likely governed by chemisorption. The equilibrium removal capacities of α‐MnO2, β‐C2S, and α‐MnO2/β‐C2S nanocomposite were found to be 25, 34.48, and 52.63 mg/g, respectively, which are very close to experimental values. Adsorption of PO43− onto adsorbents could be favorably described by the Langmuir model. D‐R isotherm model fitting showed physical adsorption by β‐C2S and α‐MnO2/β‐C2S nanocomposites and chemisorption on α‐MnO2. The maximum adsorption capacities (qm) of the adsorbents calculated from the Langmuir model were 28.58, 44.03, and 63.65 mg/g α‐MnO2, β‐C2S, and α‐MnO2/β‐C2S nanocomposites respectively. The thermodynamic parameters showed that the adsorption process occurs spontaneously with an exothermic nature and a decrease in randomness. The presence of coexisting Cl− anions decreases the adsorption capacity.
The effects of obesity on longitudinal ventricular and atrial strain in a rural population of Spanish children and adolescents, evaluated by a new strain software
Authors: Aristizábal‐Duque Cristhian H. , Fernández Cabeza Juan , Blancas Sánchez Isabel María , Delgado Ortega Mónica , Aparicio‐Martinez Pilar , Romero Saldaña Manuel , Fonseca del Pozo Francisco Javier , Álvarez‐Ossorio Manuel Pan , Ruíz Ortiz Martín , Mesa Rubio María Dolores 
Published: August 2023

SummaryBackground and ObjectivesResearch on the relationship between body mass index (BMI) and strain values in children and adolescents is limited. Our aim was to analyse the relationship between BMI and strain values of both ventricles and left atrium in children and adolescents.MethodsBoth ventricles and left atrial strain values were compared among different BMI categories in children and adolescents from a town in the South of Spain.ResultsOf the 198 subjects, aged 6–17 years, 53% were of normal weight, 26% were overweight and 21% had obesity. Lower absolute values of left ventricular global longitudinal strain (25.9 ± 2.0% vs. 26.9 ± 2.2%, p = 0.002) and right ventricular free wall longitudinal strain (29.5 ± 4.2% vs. 30.8 ± 4.5%, p = 0.04) were found in subjects with obesity and overweight versus subjects with normal weight. A lower right ventricular four‐chamber longitudinal strain was also observed in males with obesity and overweight (24.8 ± 3.3% vs. 26.4 ± 3.6%, p = 0.03). Statistically significant negative correlations of BMI were found for all ventricular, but not atrial, strain values in univariate analysis. This association turned non‐significant for right ventricular four‐chamber longitudinal strain in multivariate analysis.ConclusionsUtilizing this new strain software, children and adolescents with high BMI were associated with significantly lower values for left and right ventricular free wall longitudinal strain, without impact in left atrial strain.
Knowledge, attitude, and sources of information towards burn first aid among people referred to a burn centre in the north of Iran
Authors: Tolouei Mohammad , Pirooz Amir , Ashoobi Mohammad Taghi , Davoudpour Ravak , Zarei Reza , Sadeghi Mahsa , Mehdipour Fatemeh , Bagheri Toolaroud Parissa 
Published: August 2023

AbstractOptimal management of burns begins with first aid from the first hours of injury. Adequate knowledge of how to perform first aid for burns can reduce the consequences of injury. Therefore, this study aims to determine the knowledge, attitude, and sources of information assessment towards burn First aid among people referred to a burn centre in the north of Iran. A questionnaire‐based survey was conducted to assess knowledge, attitude, and sources of information towards burn first aid among people referred to a burn centre in the north of Iran in 2023. In this survey, a convenience sampling method was adopted. The variables consisted of four items on socio‐demographic information, 15 items on knowledge, ten items on attitude, and one item on sources of information related to burn First aid. A total of 371 individuals responded to the survey. The mean age of participants was 31.90 ± 8.49 years old. The mean score of the total knowledge of the participants in the research was 6.04 ± 3.05. There was a statistically significant relationship between the variables of age, sex, marital status, place of residence, level of education, and history of receiving first aid training with the participants' knowledge level. The average score of the total attitude of the participants was 44.08 ± 3.88. Out of 371 participants, 214 people (57.7%) had an average attitude, and 157 people (42.3%) had a good attitude towards burn first aid. There was a statistically significant relationship between place of residence, level of education, and history of receiving first aid training with the participants' attitudes in the research. In addition, the level of knowledge had a statistically significant relationship with the participants' attitude level in the research (p‐value <0.001). The majority of participants have limited knowledge of burn first aid. This lack of knowledge could lead to severe consequences. Therefore, healthcare organizations should review and promote consistent guidelines for burn first aid to tackle and minimize the effect of this grave injury.
Endomyocardial substrate of ventricular arrhythmias in patients with autoimmune rheumatic diseases
Authors: Reithmann Christopher , Kling Theresia , Metani Manjola , Klingel Karin , Ulbrich Michael 
Published: August 2023

AbstractIntroductionDelayed enhancement‐magnetic resonance imaging (DE‐MRI) has demonstrated that nonischemic cardiomyopathy is mainly characterized by intramural or epicardial fibrosis whereas global endomyocardial fibrosis suggests cardiac involvement in autoimmune rheumatic diseases or amyloidosis. Conduction disorders and sudden cardiac death are important manifestations of autoimmune rheumatic diseases with cardiac involvement but the substrates of ventricular arrhythmias in autoimmune rheumatic diseases have not been fully elucidated.Methods and Results20 patients with autoimmune rheumatic diseases presenting with ventricular tachycardia (VT) (n = 11) or frequent ventricular extrasystoles (n = 9) underwent DE‐MRI and/or endocardial electroanatomical mapping of the left ventricle (LV). Ten patients with autoimmune rheumatic diseases underwent VT ablation. Global endomyocardial fibrosis without myocardial thickening and unrelated to coronary territories was detected by DE‐MRI or electroanatomical voltage mapping in 9 of 20 patients with autoimmune rheumatic diseases. In the other patients with autoimmune rheumatic diseases, limited regions of predominantly epicardial (n = 4) and intramyocardial (n = 5) fibrosis or only minimal fibrosis (n = 2) were found using DE‐MRI. Endocardial low‐amplitude diastolic potentials and pre‐systolic Purkinje or fascicular potentials, mostly within fibrotic areas, were identified as the targets of successful VT ablation in 7 of 10 patients with autoimmune rheumatic diseases.ConclusionGlobal endomyocardial fibrosis can be a tool to diagnose severe cardiac involvement in autoimmune rheumatic diseases and may serve as the substrate of ventricular arrhythmias in a substantial part of patients.
miR‐3133 inhibits gastrointestinal cancer progression through activation of Hippo and p53 signalling pathways via multi‐targets
Authors: Zhou Ling , Guo Hui , Liao Quan , Zou Jianping , Le Yi , Fang Ziling , Xiong Jianping , Huang Shanshan , Deng Jun , Xiang Xiaojun 
Published: August 2023

AbstractBackgroundMalignant cell growth and chemoresistance, the main obstacles in treating gastrointestinal cancer (GIC), rely on the Hippo and p53 signalling pathways. However, the upstream regulatory mechanisms of these pathways remain complex and poorly understood.MethodsImmunohistochemistry (IHC), western blot and RT‐qPCR were used to analyse the expression of RNF146, miR‐3133 and key components of Hippo and p53 pathway. CCK‐8, colony formation, drug sensitivity assays and murine xenograft models were used to investigate the effect of RNF146 and miR‐3133 in GIC. Further exploration of the upstream regulatory mechanism was performed using bioinformatics analysis, dual‐luciferase reporter gene, immunoprecipitation assays and bisulfite sequencing PCR (BSP).ResultsClinical samples, in vitro and in vivo experiments demonstrated that RNF146 exerts oncogenic effects in GIC by regulating the Hippo pathway. Bioinformatics analysis identified a novel miRNA, miR‐3133, as an upstream regulatory factor of RNF146. fluorescence in situ hybridization and RT‐qPCR assays revealed that miR‐3133 was less expressed in gastrointestinal tumour tissues and was associated with adverse pathological features. Functional assays and animal models showed that miR‐3133 promoted the proliferation and chemotherapy sensitivity of GIC cells. miR‐3133 affected YAP1 protein expression by targeting RNF146, AGK and CUL4A, thus activating the Hippo pathway. miR‐3133 inhibited p53 protein degradation and extended p53's half‐life by targeting USP15, SPIN1. BSP experiments confirmed that miR‐3133 promoter methylation is an important reason for its low expression.ConclusionmiR‐3133 inhibits GIC progression by activating the Hippo and p53 signalling pathways via multi‐targets, including RNF146, thereby providing prognostic factors and valuable potential therapeutic targets for GIC.
Cas9‐targeted Nanopore sequencing rapidly elucidates the transposition preferences and DNA methylation profiles of mobile elements in plants
Authors: Merkulov Pavel , Gvaramiya Sofya , Dudnikov Maxim , Komakhin Roman , Omarov Murad , Kocheshkova Alina , Konstantinov Zakhar , Soloviev Alexander , Karlov Gennady , Divashuk Mikhail , Kirov Ilya 
Published: August 2023

ABSTRACTTransposable element insertions (TEIs) are an important source of genomic innovation by contributing to plant adaptation, speciation, and the production of new varieties. The often large, complex plant genomes make identifying TEIs from short reads difficult and expensive. Moreover, rare somatic insertions that reflect mobilome dynamics are difficult to track using short reads. To address these challenges, we combined Cas9‐targeted Nanopore sequencing (CANS) with the novel pipeline NanoCasTE to trace both genetically inherited and somatic TEIs in plants. We performed CANS of the EVADÉ (EVD) retrotransposon in wild‐type Arabidopsis thaliana and rapidly obtained up to 40× sequence coverage. Analysis of hemizygous T‐DNA insertion sites and genetically inherited insertions of the EVD transposon in the ddm1 (decrease in DNA methylation 1) genome uncovered the crucial role of DNA methylation in shaping EVD insertion preference. We also investigated somatic transposition events of the ONSEN transposon family, finding that genes that are downregulated during heat stress are preferentially targeted by ONSENs. Finally, we detected hypomethylation of novel somatic insertions for two ONSENs. CANS and NanoCasTE are effective tools for detecting TEIs and exploring mobilome organization in plants in response to stress and in different genetic backgrounds, as well as screening T‐DNA insertion mutants and transgenic plants.
Unsettling the return: Alternative curation and counterarchives
Authors: Bigenho Michelle , Stobart Henry 
Published: August 2023

AbstractIn this article, we complicate the notion of sonic return in the context of postmillennial digital media technologies that have transformed how Indigenous people of the Bolivian Andes engage self‐reflectively with their own music and dance practices. We take a capacious approach to the notion of the archive and argue that these media interactions, where people make and circulate their own audiovisual materials, represent a space of counterarchival work. We consider our distinct and changing approaches to sound recordings in our respective fieldwork and highlight how media‐making agency has entered the hands of Indigenous actors. Notable here is a striking preference for the audiovisual over the solely audio, a preference that throws into relief the idea of the sound archive and its future. We point to alternative forms of audiovisual curation that may not be shaped to the ends foreign researchers might imagine, but that nevertheless might lead to more decolonized engagements of the future. We consider a video—created as part of a campaign for women's singing of Potosí to be legally recognized in heritage law—and explore how this seemingly outsider‐focused audiovisual production involved Indigenous people in its making, reception, and recursive recirculation. We approach these issues by drawing on our multidecade and cross‐disciplinary research trajectories in the Bolivian Andes and our more recent collaborative research on heritage lawmaking during the government of Evo Morales (2006–2019).
“RIPEnglish”: Race, class and ‘good English’ in India
Authors: Highet Katy 
Published: August 2023

AbstractThis article explores how metapragmatic discourses on “good” and “bad” English in India are mobilized in ways that allow actors to negotiate their status as English speakers. Adopting an intersectional framework that highlights the relationality of colonial, racialized, and classed claims to authority, the article shows how the co‐naturalization of language and race shapes assessments of competency and legitimacy and how this is mitigated through anti‐Blackness and appeals to class status. These judgments of “good” and “bad” English work to reassert and undermine racialized authority over the language and position actors within an imagined, global stratified community of speakers. This ambivalent positioning not only helps actors negotiate relational legitimacy as English speakers but also works strategically to benefit certain speakers and reproduce colonial, class, and racial orders.
Influences of flavonoid (quercetin) inclusion to corn‐soybean‐gluten meal‐based diet on broiler performance
Authors: Biswas Sarbani , Cho Sungbo , Ahn Je Min , Kim In Ho 
Published: August 2023

AbstractQuercetin (a predominant flavonoid) is considered to have antimicrobial and antioxidant properties. This trial was conducted to evaluate the impact of graded doses of quercetin (QS) on growth efficiency, nutrient retention, faecal score, footpad lesion score, tibia ash and meat quality. In a 32‐day feeding test, a total of 576 1‐day‐old Ross 308 broilers (male) were allocated arbitrarily with an average body weight of 41 ± 0.5 g. The trial had four dietary treatments with eight repetitions of 18 birds per pen and a basal diet incorporating 0%, 0.02%, 0.04% and 0.06% of QS. As the QS dosage increased, body weight gain tended to increase linearly on Days 9–21 (p = 0.069) and overall period (p = 0.079). Similarly, feed intake increased (p = 0.009) linearly with the increasing doses of QS on Days 9–21. Likewise, there was a linear improvement in dry matter (p = 0.002) and energy (p = 0.016) digestibility after QS administration. Moreover, the inclusion of QS supplement (0%–0.06%) linearly increased (p = 0.012) tibia ash in broilers. However, the faecal score and footpad lesion score showed no significant outcome (p > 0.05). By giving broilers a graded amount of QS, the relative organ weights of breast muscle (p = 0.009) and spleen (p = 0.006) improved linearly, meat colour lightness increased (p = 0.015), redness tended to improve (p = 0.065) linearly and drip loss decreased (p = 0.015) linearly. The inclusion of QS in the graded‐level diet led to improvements in growth efficiency, nutrient absorption, meat quality and tibia ash, which recommended it as a beneficial feed additive for the broiler.
Changes in diet and supplement use in dogs with cancer
Authors: Kramer Matthew L. , Larsen Jennifer A. , Kent Michael S. 
Published: August 2023

AbstractBackgroundMany dog owners alter their dog's nutritional regimen after a diagnosis of cancer. There are limited data as to specific changes made and reasons behind these changes.Hypothesis/ObjectivesTo collect updated and detailed data on changes made by owners to their dog's diet and supplements after a cancer diagnosis.AnimalsResponses were collected from a survey of dog owners who brought their dogs to the UC Davis Veterinary Medical Teaching Hospital's Oncology Service for the first time after a cancer diagnosis. Dogs with recurrence or presenting for a second type of cancer were excluded.MethodsEligible owners were surveyed between December 2020 and March 2022. The survey contained 62 questions regarding diet, supplement use, and treats, and how these were altered after a cancer diagnosis. Responses were matched to medical record data.ResultsOne hundred twenty‐eight surveys were retained for analysis, including 120 respondents that completed the survey. In response to a cancer diagnosis, 54.8% (95% CI; 45.7%‐63.8%) of owners altered diets or supplements or both. The most common informational resource for dog diets was veterinarians (53.9%). Usage of home‐prepared foods significantly increased after a cancer diagnosis (P = .03). There was no significant difference in commercial diet usage before or after a diagnosis (P = .25). Joint support products were the most common supplements given both before (37.4%) and after (35.0%) diagnosis.Conclusions and Clinical ImportanceMany dog owners alter their dog's nutritional intake after a cancer diagnosis. These owners should be provided information relating to commonly observed alterations, including home‐prepared foods and supplements.
Anthropological knowledge under redaction: Meditations on race, health, and aesthetics
Authors: Edu Ugo Felicia 
Published: August 2023

AbstractEmerging from experimentations with form during our 2021 inaugural BFHSS Collaboratory, this article dabbles in redaction while examining logics of race and aesthetics embedded in how health is defined, measured, and depicted. I also examine logics structuring who is legible as a producer of knowledge, whose body is one from which knowledge is extracted, and who can be given access to population groups for study. Form in this article offers a reflection on the appropriateness of Blackness and pushes for a reconsideration of the relationship between form and function, appropriate claim‐making, article writing, and engagement with scholarship.
Rice chromatin protein OsHMGB1 is involved in phosphate homeostasis and plant growth by affecting chromatin accessibility
Authors: Wang Yan , Wang Fei , Lu Hong , Lin Rongbin , Liu Jiaming , Liu Yu , Xu Jiming , Wu Yunrong , Wang Zhiye , Zhou Ming , Mo Xiaorong , Wu Zhongchang , Shou Huixia , Zheng Shaojian , Mao Chuanzao 
Published: August 2023

Summary
Although phosphorus is one of the most important essential elements for plant growth and development, the epigenetic regulation of inorganic phosphate (Pi) signaling is poorly understood.
In this study, we investigated the biological function and mode of action of the high‐mobility‐group box 1 protein OsHMGB1 in rice (Oryza sativa), using molecular and genetic approaches.
We determined that OsHMGB1 expression is induced by Pi starvation and encodes a nucleus‐localized protein. Phenotypic analysis of Oshmgb1 mutant and OsHMGB1 overexpression transgenic plants showed that OsHMGB1 positively regulates Pi homeostasis and plant growth. Transcriptome deep sequencing and chromatin immunoprecipitation followed by sequencing indicated that OsHMGB1 regulates the expression of a series of phosphate starvation–responsive (PSR) genes by binding to their promoters. Furthermore, an assay for transposase‐accessible chromatin followed by sequencing revealed that OsHMGB1 is involved in maintaining chromatin accessibility. Indeed, OsHMGB1 occupancy positively correlated with genome‐wide chromatin accessibility and gene expression levels.
Our results demonstrate that OsHMGB1 is a transcriptional facilitator that regulates the expression of a set of PSR genes to maintain Pi homeostasis in rice by increasing the chromatin accessibility, revealing a key epigenetic mechanism that fine‐tune plant acclimation responses to Pi‐limited environments.
Light induces an increasing release of benzyl nitrile against diurnal herbivore Ectropis grisescens Warren attack in tea (Camellia sinensis) plants
Authors: Qian Jiajia , Liao Yinyin , Jian Guotai , Jia Yongxia , Zeng Lanting , Gu Dachuan , Li Hanxiang , Yang Yuhua 
Published: August 2023

AbstractHerbivore‐induced plant volatiles (HIPVs) are critical compounds that directly or indirectly regulate the tritrophic interactions among herbivores, natural enemies and plants. The synthesis and release of HIPVs are regulated by many biotic and abiotic factors. However, the mechanism by which multiple factors synergistically affect HIPVs release remains unclear. Tea plant (Camellia sinensis) is the object of this study because of its rich and varied volatile metabolites. In this study, benzyl nitrile was released from herbivore‐attacked tea plants more in the daytime than at night, which was consistent with the feeding behaviour of tea geometrid (Ectropis grisescens Warren) larvae. The Y‐tube olfactometer assay and insect resistance analysis revealed that benzyl nitrile can repel tea geometrid larvae and inhibit their growth. On the basis of enzyme activities in transiently transformed Nicotiana benthamiana plants, CsCYP79 was identified as a crucial regulator in the benzyl nitrile biosynthetic pathway. Light signalling‐related transcription factor CsPIF1‐like and the jasmonic acid (JA) signalling‐related transcription factor CsMYC2 serve as the activator of CsCYP79 under light and damage conditions. Our study revealed that light (abiotic factor) and herbivore‐induced damage (biotic stress) synergistically regulate the synthesis and release of benzyl nitrile to protect plants from diurnal herbivorous tea geometrid larvae.
Spatial outward FDI: Evidence from China's multinational firms
Authors: Xie Yiqing , Yu Xiaobo , Yu Zhihong , Zhou Yu 
Published: August 2023

AbstractThis paper studies the impacts of geographic proximity and investment connection on the outward foreign direct investment (OFDI) decisions by Chinese multinational firms, including both greenfield investment and cross‐border merger and acquisition. We model firms' OFDI expansion with the lagged spatial structure, and collect outward FDI data of 3479 Chinese multinational firms from 2002 to 2013 whose investment destination covers more than 160 countries. We find that the spatial expansion of firms' existing OFDI play an important role in shaping their future investment decisions. Firstly, firms tends to invest in destinations that are closer to China, and expand further into destinations that are geographically closer to their existing OFDI locations. This is the geographic network effect. Secondly, we also find that firms are more likely to invest in countries with more intense FDI from China, and extend their OFDI networks to destinations with stronger investment connections with their existing subsidiary locations. This is the investment network effect. We show that these two effects are robust to alternative investment and geographic network measures and further controls.