bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sub-Lethal Effects Of Chlorpyrifos On Geno-Neurotoxic Profiles In Freshwater Fish Cyprinus Carpio(L.)
Authors: Kareema Ambareen , Mididoddi Venkateshwarlu  
Published: February 2023

Pesticide toxicity is a global concern and chlorpyrifos is one of the most widely used organophosphate agrochemicals,it is frequently detected in surface ground waters of India. Chlorpyrifos(CPF) LC50 – 96 h was calculated as 0.318 mg/l using probit analysis based on LC50 value two sublethal concentrations of 1/5th of LC50 (0.0636 mg/l) and 1/10th of LC50 (0.0318 mg/l) were determined. The influence of CPF on the acetylcholinesterase (AChE) activity and Ach content and the Genotoxicity of Cyprinus carpio was evaluated. Results confer that significant inhibition in the AchE activity in brain tissue resulting in a build-up of Ach at the neuronal synapse resulting in a decrease of cholinergic transmission finally impairs the neurophysiological activity and ultimately result in the death of fish although studies on genotoxic effects of CPF were carried out to examine the prevalence of nuclear abnormalities in freshwater fish Cyprinus carpio using Comet and MN assay in blood erythrocytes and gill cells as percentile tail DNA damage as comets and micronuclei and other nuclear anomalies were scored in erythrocytes of Cyprinus carpio it was found that significant effect was observed for both concentrations and periods of exposure in the treated fishes. The highest DNA damage and increased micronuclei frequency and inhibitory AchE activity in Cyprinus carpio were found to be high on the highest sublethal 1/5th of LC50 followed by Sublethal 1/10th of LC50 concentration. Overall findings imply that AchE and genotoxic biomarkers may be useful diagnostic tools for chlorpyrifos poisoning in biomonitoring programs.
Voltaire, (6c) Lettres sur les Anglais (III) LETTRES SUR M. LOCKE, Voltaire Foundation, 2020.
Authors: Woodward Servanne 
Published: February 2023

« La treizième des Lettres sur les Anglais porte sur Locke et la question de l’âme. La première version de la Lettre sur Locke – qui fait l’objet du présent volume – est écartée par Voltaire des Lettres sur les Anglais en 1733 à cause de ses audaces quasi-matérialistes qui risquaient d’entraîner la censure de l’ensemble de l’ouvrage, et elle est remplacée par la version édulcorée que nous connaissons aujourd’hui en tant que Lettre 13. Voltaire reprend la première version en 1736 et développe la comparaison entre l’homme et l’animal, vers l’affirmation d’un lien essentiel entre l’‘organisation’ des corps et leurs propriétés cognitives. La Lettre lui échappe alors et connaît une circulation manuscrite et de nombreuses éditions au cours du dix-huitième siècle. Elle jouera un rôle important dans l’émergence de la pensée matérialiste au cœur des Lumières françaises. » http://www.voltaire.ox.ac.uk/publication/lettres-sur-les-anglais-iii/
Securing Medical Datasets using Block Chain Technology
Authors: Khan Sikander , Ahmed Faisal , Baig M. Sawood , Khan Zaryab Ahmed , Yousufzai Usama Ayub 
Published: February 2023

Medical data sets are crucial in modern healthcare as they provide valuable information that helps in advancing medical research, improving patient care, and making informed decisions. They allow healthcare providers to track patient health records, evaluate treatments and outcomes, and identify trends and patterns in disease diagnosis and management. Additionally, medical data sets are used for training AI models that can assist healthcare professionals in diagnosing and treating diseases, providing accurate and timely patient care, and reducing medical errors.
In recent years millions of patient records have already been compromised due to data thefts in the healthcare industry ranging from patient’s private health data to hospitals accounting, reporting, DNA structures etc. are all being taken. Blockchain technology, which is regarded as a trustworthy way to maintain documents, could be utilized to protect full security and confidentiality. This approach would not only safeguard patient data but also due to decentralized structure of a technology it also lead to more efficient treatment of patients as information would be readily and instantly available. Therefore, proper implementation of the blockchain system will not only increase individual service but also remove the need for external parties to provide security.
The study proposed a model that would unites almost all of the leading healthcare providers, by combining all Electronic Health Record (EHR) system including hospitals, clinics, and specialized Laboratories as well. MedBloc, a blockchain-based safe EHR system that offers accessibility, safety, and protection is described. It allows both patients and healthcare professionals to view and exchange medical records, by extracting important ideas that can be used to create multiple blockchain systems and vulnerability scanning that address security flaws. This article also presents blockchain vulnerability management options by analyzing some assaults upon blockchain, including hashing, connectivity, smart contract and privacy breach cyberattacks. It has been proven difficult as a result of trustworthy attack analysis techniques. Therefore, we explore the blockchain's user privacy in this paper and consider potential fixes. We systematically divide the three kinds of blockchain attack strategies, then mentioned the associated attack and defense techniques that rely on such divisions.
ASPEK KEADILAN ATURAN PAJAK INDONESIA DALAM MENGATUR TRANSAKSI EKONOMI DIGITAL: RESPON ATAS INVESTIGASI USTR
Authors: Burnama Indrajaya 
Published: February 2023

The growth of digital economy around the world is rapidly increasing. According to a study by Google, Temasek, Bain, and Statista, Indonesia should be the largest digital economic market in South East of Asia. Therefore, a lot of people and industry involved in the digital economy from overseas came to Indonesia. However they are not implementing the tax obligation at all, not only income tax but also value added tax. So, they raise injustice among people and industry involved with digital economy. Until the government released Minister of Finance Decree number 35 Year 2019, Act number 2 Year 2020 and Minister of Finance Decree number 48 Year 2020. However, the regulations were being investigated by United States Trades Representative (USTR). This research discusses implementation of the principle of justice in several tax regulations that regulate digital economic activity as well as current example such as France, Australia and Singapore. This research uses a descriptive qualitative approach. The purpose of this research is to find out the application of the principle of justice in tax regulations related to the digital economy that has been carried out by the government.
Kosmopolitanisme Islam Dalam Indikator Moderasi Beragama Di Indonesia
Authors: Islamy Athoillah , Susilo Adib 
Published: February 2023

The mainstreaming of religious moderation is not always responded positively by religious people in Indonesia. For example, there is a bad stigma that views the mainstreaming as religious liberalization. This research aims to identify the existence of cosmopolitan Islamic values in the indicators of religious moderation formulated by the Ministry of Religion of the Republic of Indonesia. This qualitative research in the form of a literature study uses a normative-philosophical approach. The cosmopolitan Islamic paradigm initiated by Abdurrahman Wahid became an analytical theory in the core discussion. This research shows that there are dimensions of cosmopolitan Islamic values in four indicators of religious moderation in Indonesia. First, the value of Islamic universalism in indicators of tolerance and anti-radicalism. This can be seen from the mainstreaming of religious moderation which emphasizes the formation of moderate Muslim religious understandings and attitudes in respecting social plurality and human values. Second, the value of Islamic pribumization in indicators of national commitment and accommodating to local wisdom. This can be seen from the mainstreaming of religious moderation which emphasizes the formation of moderate Islamic religious understanding and social attitudes in maintaining nationalism and wisdom of local traditions that do not violate Islamic teachings. The theoretical implications of this study show that there is a need for moderate understanding and social attitudes of Muslim diversity in the life of a cosmopolitan society. The limitations of this research have not examined the strategy of Pesantren as a subculture in the cosmopolitan Islamic paradigm initiated by Abdurrahman Wahid, namely related to the internalization of cosmopolitan Islamic values in order to form understanding and social attitudes of moderate diversity for Muslims in Indonesia.
INTESTINAL INTUSSUSCEPTION SECONDARY TO JEJUNAL ADHESIONS IN ADULT: A RARE CAUSE OF POSTOPERATIVE OBSTRUCTION
Authors: ZL Randimbinirina , F Rasoaherinomenjanahary , CE Solo , ZA Meliny , MLA Ravalisoa , LH Samison 
Published: February 2023

Although intussusception is always seen in children, its occurrence in adults is an exceptional situation. Postoperative intussusception is uncommon and few cases have been reported in the literature. We present the case of a 51-year-old woman with jejunal postoperative intussusception. She underwent gastrojejunal anastomosis for pyloric stenosis two weeks earlier. The symptomatology was a bowel obstruction, which was initially thought to be an early postoperative adhesions. The lack of improvement despite medical treatment led to a surgical exploration that helped to the right diagnosis. Intussusception has been related to jejunal adhesions. Manual reduction was made with removal of adhesions. Postoperative period was uneventful. Adult intussusception is uncommon, often caused by tumors. Early surgical revision is the rule to avoid nutritional impact of a chronic postoperative subocclusion.
USE OF THE “VERTICAL RECTUS ABDOMINIS MYOCUTANEOUS FLAP” MODIFIED FOR PELVIC RECONSTRUCTION AFTER TRAUMATIC REMOVAL OF THE HEMIPELVIS
Authors: A.r Raherison , M.f Ralahy , V.s Nirinaharimanitra , L.r.c Andriamanarivo , F.a Hunald , m.l Andriamanarivo 
Published: February 2023

Reconstructive surgery in case pelvis defect is a technical challenge. It takes into account the etiology, the general condition of the patient; the location and size of the defect. Pedicled musculocutaneous flaps is necessary in case of deep and large defect. The rectus abdominis flap is frequently used. Our observation demonstrates the difficulties and technical particularities of reconstructing a large traumatic defect. It is a rupture of the hemipelvis following a traffic accident, exposing the peritoneum, part of the bladder and the anal canal. The use of fasciocutaneous flap was doomed to necrosis. Our recourse was the use of the "vertical rectus abdominis myocutaneous flap" (VRAM) by making a technical modification. The muscle was dissected separately from the fascia. This allowed us to spread it out and cover a wider area. Complete cutaneous coverage was provided by using two fasciocutaneous flaps: hypogastric and perineal. Good healing was obtained, and the patient received a prosthesis.
ELECTROCLINICAL ASPECTS OF OCCIPITAL EPILEPSY SEEN IN THE NEUROSCIENCES AND MENTAL HEALTH LABORATORY ANTSAKAVIRO
Authors: Lemahafaka jg  , J Razafimahefa , D Raharimaminjatovosoa , Ad Tehindrazanarivelo 
Published: February 2023

Introduction: Occipital epilepsy occurs when the initial site of epileptic discharge involves part or all of the occipital lobe. Occipital epilepsy is the least common of the other types of epilepsy and is rarely described in the literature. However, the manifestation located initially in the occipital cortex, which is a functional zone of vision, leads to its protean aspect. It can be a source of diagnostic wandering. The purpose of this study is to describe the electroencephalographic clinical characteristics of patients seen for occipital epilepsy at the Laboratory of Neurosciences and Mental Health, Antsakaviro, Madagascar.
Methods: This is a retrospective and descriptive study that took place over a one-year period (January 2016 to December 2016). Included in this study were all patients diagnosed with clinically and EEG-confirmed occipital epilepsy. A correlation between clinical manifestations and electroclinical data is sought.
Results: We retained 66 patients with male predominance (sex ratio: 1.4). The age of the patients ranged from 3 to 55 years with a mean age of 13.77 years. Patients reside in urban areas and the majority are of non-school age. The clinical manifestations of occipital epilepsy are mainly paroxysmal visual hallucinations lasting on average 3 minutes and of variable frequency. EEG signs are predominantly paroxysmal activities with a predominant or occipital starting point.
Conclusion: The clinical and electroencephalographic manifestations of occipital epilepsy deserve special attention in order to make a proper diagnosis.
INFLAMMATION CHRONIQUE ET HYPERPLASIE BÉNIGNE DE LA PROSTATE: FACTEURS PRÉDICTIFS ET CONSÉQUENCES APRÈS CHIRURGIE OUVERTE CHRONIC INFLAMMATION AND BENIGN PROSTATIC HYPERPLASIA: PREDICTIVE FACTORS AND CONSEQUENCES AFTER OPEN SURGERY
Authors: Andrianisa H Rambel , Nirina MOJ Harioly , F Rasoaherinomenjanahary , AF Rakototiana , HYH Rantomalala 
Published: February 2023

Background: Chronic inflammation of the prostate has been observed on prostatic specimen after resection or a biopsy. The aim of this study was to determine the factors that can predict its existence in benign prostatic hyperplasia (BPH) and the consequences after open surgery. Method: We carried out a retrospective, observational, transversal study of patients who underwent prostatic adenomectomy in 2017 and 2018 in our department. Specimen with prostatic adenocarcinoma were excluded.
Results: Of 51 operated patients, 31 (60.78%) had chronic inflammation within BPH. The mean delay between the beginning of symptoms and the surgery was 23.14 ± 35.62 months.
Acute urinary retention was the main reason for consultation (78.43%). The mean duration of bladder catheter wear before surgery was 82.41 ± 220.36 months. Postoperative course was uneventful in 26(50.99%) patients. The mean postoperative stay was 5.86 ± 3.42 days. Surgical treatment delay (p = 0.000001), surgical wound infection (p = 0.002) and the length of postoperative stay (p = 0.002) had a significant correlation with prostatic chronic inflammation.
Conclusion: The delay in surgical management was the main predictor of chronic inflammation in BPH. This factor increase the risk of surgical wound infection and an extended of postoperative stay.
FACTORS INFLUENCING HIGH CHILD MORTALITY IN KAREMO SUBCOUNTY, SIAYA COUNTY –KENYA
Authors: Kagoiyo Njeru Sammy 
Published: February 2023

Study Objective: To determine factors influencing high child mortality rates at Karemo sub-County, Siaya County Kenya
Study Design: A descriptive cross sectional study
Study Setting: Karemo Sub-County, Siaya County Kenya
Study Subjects/participants: Three hundred and twenty six (326) caregivers of children under five years at house hold levels
SURGICAL MANAGEMENT OF TRAUMATIC ARTERIAL OF LIMBS IN ANTANANARIVO
Authors: ZL Randimbinirina , T Rajaobelison , RNAL Rakotorahalahy , AML Ravalisoa , AJC Rakotoarisoa 
Published: February 2023

Background: The prevalence of traumatic arterial of limbs in Antananarivo is unknown, and there is not a protocol for management of vascular trauma. The aim of this study was to describe epidemiology and surgical management of traumatic arterial of limbs in Antananarivo.
Material and methods: This was a retrospective and descriptive study for a period of 10 years from January 2008 to December 2017 performed at the Cardiovascular Surgery Unit in JRA Teaching Hospital Antananarivo, including all patients who underwent a surgery for traumatic arterial injury of limbs.
Results: Ninety-two cases of traumatic arterial of limbs has been recorded. The most victims were young (mean age=34.68), male (88.04%). The most mechanism of arterial injury was a civilian liability accident (63.04%) which 53.26% was due to stabs wounds. There were 82 cases of arterial wounds and 10 cases of blunt arterial trauma. Clinical signs were bleeding (89.12%), pulseless (46.73%) and hematoma (10.86%). Lesion were laceration (n=36), complete transection (n=32), avulsion (n=7), pseudoaneurysm (n=5), arteriovenous fistula (n=2), contusion (n=10). The most involved vessel were the brachial artery (29.34%) in the upper extremity and the femoral artery (15.21%) in lower extremity. Surgical procedure were revascularization (84.78%), ligation (9.78%) and primary amputation (5.43%). The overall limb salvage rate was 96.73% of arterial injuries successfully repaired.
Conclusion: Revascularization is important in traumatic arterial injury of limbs. It must giving early to prevent an amputation of limbs.
EDUCATIONAL IMPACT OF EPILEPSY IN CHILDREN
Authors: Noel Zodaly , jemissair glorien Lemahafaka , Naliniaina robert Randrianantoandro , Andry Rakotondramanana , Alain Djacoba Tehindrazanarivelo 
Published: February 2023

Introduction: Epilepsy can interfere with a child's cognitive development and may result in academic difficulty. Our objective is to identify and estimate the link between epilepsy and academic difficulties.
Methods: This is a prospective descriptive and analytical case-control study carried out at the Antsakaviro Laboratory of Neurosciences and Mental Health for the cases and in the four Public Primary Schools of the rural commune of Anjepy for the controls from 1st October 2014 to 31st January 2015. The frequency of school difficulties in epileptic and non-epileptic children, the relationship between epilepsy and school difficulties were evaluated.
Results: The frequency of school difficulty in children with epilepsy was 49.13% compared to 25% in non-epileptic children with an Odds Ratio of 2.90 with 95% specificity and a confidence interval of 1.87 to 4.43. Among the cases, 52.94% of the children had their first seizure before the age of 2 years with a predominance of generalized tonic-clonic seizures at 57.65%, the majority of which were of the idiopathic type (67.06%). The majority of children with epilepsy had a lack of concentration in 43.53% of cases and memory impairment in 31.76%, while memory impairment (38%), lack of concentration in 20% and repetition in 20% of non-epileptic children.
Conclusion: Epilepsy is a serious illness for the child that can lead to a learning disability.
Therefore, prevention of seizures and early detection are essential.
ETHICAL ROLE OF HEALTHCARE ORGANIZATIONS IN CHANGING BEHAVIORS OF INDIVIDUAL HEALTHCARE PROFESSIONALS IN ATTEMPT TO IMPROVE PATIENT SAFETY
Authors: Mohammad F. Alwehaibi PhD Ayyub 
Published: February 2023

In modern society, medicine is one of the domains that have to face great challenges in many aspects. The major challenge in terms of quality in health care is the safety for patients. Besides the negative consequences caused by serious conditions of the diseases, many harmful occurrences are avoidable. The occurrence of avoidable harms sometimes deprive patients’ lives or abilities, which has created great fear for patients of being at risk more than in help.
Such avoidable harms may be resulted by the healthcare professionals’ knowledge, skills, or behaviors. These harms may be caused by either human errors or violations. To prevent these errors from occurring in the future, some measurements need to be enforced on organizational level. Medical errors are unavoidable in every clinical unit as medicine is practiced by human, and human beings are not free from making mistakes. Yet, it does not mean that it is impossible to remedy the issue of medical error. Confronting the mistakes made by individuals are the organizations they work within. Organizations represent their individuals and play substantial roles of not only seeking for the solutions to the incidents but also preventing such incidents from re-occurring in the future. There are two important notions- human error and violations- which thoroughly influence on the strategies of management of unintended adverse incidents
Emergency Escape Route Design and Application
Authors: Man Yanmin 
Published: February 2023

This paper uses k-means clustering algorithm, single objective optimization model and multisource multi-sink problem shortest path algorithm to obtain the optimal path algorithm for emergency evacuation and the shortest time model.Firstly, a code of conduct for the division of terrorist attacks has been established. The number of casualties in various incidents and the scope of destructive power to public areas are counted. A three-dimensional cluster core is selected. All terrorist at- tacks are classiﬁed into three levels: level 1-3 by the k-means clustering algorithm, and the degree of harm is gradually increasing.Secondly, the optimal path from each venue to the stairway is calculated. The re- lationship between the speed of ﬂow and the number of evacuees is given in the case of three situations. The multi-source multi-sink problem is transformed into a single- source shortest path problem by adding a virtual node to all venues on the second ﬂoor of the Louvre, and the Dijkstra algorithm is called once to obtain the optimal path from the venue to all stairs.The Final step is to establish an emergency evacuation optimization model with the minimum evacuation time as the objective function. The overall evacuation time is divided into the personnel response time, the horizontal road walking time, the time down the stairs, and the waiting time when congestion occurs. the open number of emergency exits can be judging by different levels of terrorist events, and the optimal evacuation path and the shortest time for different emergency events are given. At the same time, we also analyzed the changing trend of velocity in different cases, which can be adjusted according to the actual conditions.
Development of an efficient Computational Model for classification of Tissue remodeling
Authors: Nazim Zarsha , Dr.Sajid Mahmood  , Kiran Amjad  
Published: February 2023

Tissue remodeling is one of the most important and crucial biological process. Process in which tissue reorganization and renovation takes place is called tissue remodeling. Mean of recovery in human beings is tissue remodeling in which damaged tissue are replaced completely with new tissue or through tissue repairmen types physiological and pathological tissue remodeling are two derivatives of Tissue remodeling. Normal Tissue remodeling is referred to as Physiological tissue remodeling, however abnormal process which may lead to a disease is known as pathological tissue remodeling.
From past till now different techniques like histopathology and chemicals were being used to identify abnormality in tissues. Which is a time taking and costly processes. There is no such computational method which can be used for the identification of the physiological and pathological tissue remodeling. The current article aims to develop a classification model which has ability to classify weather the given sequence is physiological or pathological process. Three classifiers RF, ANN and SVM will be used for practice and evaluation of proposed classification model.