bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex-related functional outcome after periacetabular osteotomy in mild to severe hip dysplasia
Authors: Fischer Maximilian , Nonnenmacher Lars , Hofer Andre , Zimmerer Alexander , Nitsch Andreas , Großjohann Rico , Erdmann Sabrina , Wassilew Georgi I. 
Published: January 2025

AimsPeriacetabular osteotomy (PAO) is well established for acetabular reorientation and has shown successful improvement in patient-reported outcome measures (PROMs). Nevertheless, studies focusing on postoperative outcomes related to patient individual factors are still underrepresented. Therefore, this study aimed to analyze the functional outcome and activity level in relation to patient sex with a minimum follow-up of two years after PAO for mild to severe hip dysplasia.MethodsA single-centre study was conducted, enrolling patients undergoing PAO and completing a preoperative and postoperative radiological and clinical outcome assessment. The PROMs were assessed using the modified Harris Hip Score (mHHS), the Hip disability and Osteoarthritis Outcome Score (HOOS) with the subscales for pain, sport, activities of daily living (ADL), and quality of life (QoL), and the University of California, Los Angeles (UCLA) activity score. Kendall’s tau were calculated for correlation analyses.ResultsIn total, 145 patients (28 male, 117 female) were included. The PROMs improved significantly across males and females at the latest follow-up. Female patients had significantly lower preoperative PROMs: mHHS (47 vs 57.4; p = 0.002); HOOS pain (44.9 vs 60; p = 0.003), sport (47 vs 57.4; p = 0.002), ADL (58.9 vs 69.3; p = 0.032), and QoL (26.8 vs 39.3; p = 0.009); and UCLA (5.6 vs 6.7, p = 0.042) scores. Males showed higher postoperative UCLA scores (7.5 vs 6.7; p = 0.03). Kendall’s tau showed significant negative correlation between BMI and UCLA scores in females and males (-0.21 to -0.29; p = 0.002/0.048), while BMI and HOOS sport (-0.16; p = 0.015) and ADL (-0.2; p = 0.003), as well as QoL (-0.14; p = 0.031) and preoperative acetabular inclination (-0.13; p = 0.049) were only significantly negatively correlated in females.ConclusionPatient sex affects PROMs before and after PAO. Female patients experience higher improvement in hip function and activity level, due to poorer preoperative PROMs than males. Thus, these data are particularly interesting in providing preoperative guidance regarding postoperative outcome expectations.Cite this article: Bone Jt Open 2024;6(1):35–42.
Investigation of Nb2O5/SiO2 short-wave pass filters for beam-splitting application in a PV/CSP solar hybrid system
Authors: Bourhani Said Abdallah , Tang Lei , Zhou Hui , Zhang Yanguo , Li Qinghai 
Published: January 2025

Multilayer thin-film filters for beam-splitting applications were designed, fabricated, and characterized. Optimized 13- and 35-layer Nb2O5/SiO2 filters on K9 substrates achieved wideband transmission in the range of [580–1100 nm]. Optical and structural characterizations were performed using spectrometry, atomic force microscopy (AFM), and X-ray diffraction (XRD). The Nb2O5/SiO2/K9 glass filter exhibited sensitivity to deposition conditions, especially in the very short wavelengths. Post-deposition annealing improved the filters’ morphology and optical performance, particularly in short wavelengths. Both filters demonstrated efficient performance with average transmittance values of 87.56% and 83.72%, respectively. Additionally, the highest reflectance and average reflectance in the remaining range were measured as 62.42% and 98%, respectively, making them suitable for hybrid photovoltaic thermal systems under optimized deposition and annealing conditions.
SPEED (SPlEnic Embolisation Decisions) study—Decision to treat acute traumatic splenic artery injury in the context of trauma protocol
Authors: Jenkins Paul , Zhong Jim , Harding James , Sorrell Lexy , Smith Jason , Allgar Victoria , Roobottom Carl 
Published: January 2025

Background
The spleen is commonly injured in trauma and this may be managed with a conservative approach, embolisation or splenectomy. There is uncertainty how splenic embolisation fits into the treatment paradigm and the delivery of IR services remains variable.

Aims and objectives
The primary objectives are to determine if service design significantly affects splenic embolisation (SE) rates in AAST grade 2–5 acute traumatic splenic injuries (ATSI) across the Major Trauma Centres (MTCs) in England and to determine if variation in treatment affects SE outcomes in ATSI.

Methods
We will include 5 years of data from traumatic splenic injury patients in the MTCs from 01/01/2016 to 31/12/2020 available from the Trauma Audit and Research Network (TARN) database. Inclusion Criteria will be all patients with ATSI registered with TARN. Those without a CT available to grade radiologically will be excluded. Data available from the TARN database and then correlated with data that will be collected at each MTC, where detail as to the embolisation technique, specific injury pattern, imaging based follow up and patient survival will be available. A short service-based questionnaire will be sent to each centre to establish centre-specific details such as on call rota, IR response activation, reporting practices and capture data around routine decision-making at that site. Data will be collected on an anonymised (REDCap) database. This project will evaluate the impact of service design on embolisation rates and outcomes, as well as evaluating the impact of the variation upon treatment selection and outcomes. Logistic regression will be used to identify factors associated with treatment selection and mortality at 30 days.
Phenotypic identification of Metallo-ß- lactamase resistance Gram negative bacteria from a clinical specimen in Sidama, Ethiopia
Authors: Alemayehu Tsegaye , Abera Wondwesson , Ali Musa Mohammed , Jimma Bethelihem , Ayalew Henok , Habte Limenih , Teka Frezer , Asegu Demissie 
Published: January 2025

Background
Metallo-beta lactamase resistance is one of the carbapenem resistances that worsen the world nowadays. A new variant of carbapenem-resistant has only limited reports from Africa including Ethiopia. This study aimed to determine Metallo -ß- lactamase resistance Gram-negative bacteria in Hawassa University Comprehensive Specialized Hospital January–June 2023.

Method
A cross-sectional study was conducted in which consecutive patients infected with Gram-negative bacteria were included in the study. A structured questionnaire was used to collect the data with oriented nurses if the patients/or caregivers gave consent to participate in the study. Clinical specimens are processed based on the standard operating procedure of the Microbiology laboratory and Clinical laboratory standard institute guidelines. Culture and sensitivity testing was used to isolate the bacteria. Gram staining and biochemical tests was used to identify the bacteria to genus and species. Kirby disc diffusion technique was used to determine the susceptibility of antibiotics. Statistical Software for Social Science (SPSS) version 21 is used for data entry and analysis. Descriptive statistics and logistic regression were used to interpret the data. The odds ratio at 95% confidence interval (CI) and p-value < 0.05 were taken as a statistically significant association.

Result
Our study included 153 isolates from different specimens, 83 (54.2%) were from male patients and 70 (45.8%) were from females. Klebsiella pneumonia was the predominant 43, followed by Escherichia coli 32, Acinetobacter spp 25, Pseudomonas spp 15, Enterobacter agglomerus 9, Klebsiella ozaenae 6, Enterobacter cloacae 5, Klebsiella oxytoca 4, (Klebsiella rhinoscleromatis, Proteus mirabilis and Morganella morganii) 3, Providencia stuartii 2 and (Citrobacter spp & Proteus vulgaris) 1. The rates of multi, extensive and pan-drug resistance bacteria accounted for 128/153 (83.7%), 77 /153(50.3%), and 26/153 (17.0%), respectively. Carbapenem resistance was 21 (13.7%), of this 7.2% were Enterobacteriaceae, 5.2% were Acetinobacter spp. and 1.3% Pseudomonas spp. Metallo-beta-lactamase was 17 (11.1%), of this, Enterobacteriaceae were 9(5.9%), Acetinobacter spp. 7(4.6%), and Pseudomonas spp. 1(0.7%). There were no variables statistically significantly associated with metallo-beta-lactamase-resistant.

Conclusion
Our study revealed that Metallo-beta-lactamase resistance was circulating in the study area. There was a high rate of carbapenem resistance, multi, extensive and pan-drug resistance. Therefore, a measure should be taken to alleviate the emerging threat that leaves the patients without the option of treatment.
Association between normal weight obesity and comorbidities and events of cardiovascular diseases among adults in South China
Authors: Ma Miaomiao , Lv Deliang , Wu Xiaobing , Chen Yuqing , Dai Shimiao , Luo Yutian , Yang Hui , Xie Wei , Xie Fengzhu , Shang Qinggang , Zhang Ziyang , Zhao Zhiguang , Zhou Ji-Chang 
Published: January 2025

Background
The increased risks for cardiovascular comorbidities and cardiovascular diseases (CVD) in populations with normal weight obesity (NWO) have not been well-identified. We aimed to study their associations in an adult population in South China.

Methods
Based on the CVD prevalence of 4% in Shenzhen and a calculated sample size of 6,000, a cross-sectional study with a multi-stage stratified cluster sampling method was conducted in Shenzhen City. The cardiovascular comorbidities being studied were abdominal obesity (AO), diabetes, hypertension, dyslipidemia, metabolic syndrome, and chronic kidney disease, while the CVD events were occurrences of myocardial infarction and strokes. Questionnaire surveys, physical examinations, and laboratory tests were performed. NWO was defined as a condition with the highest tertile of body fat percentage (BF%) among the normal body mass index (BMI) range (18.5–23.9 kg/m2). Continuous data were reported as mean [standard deviation (SD)] and categorical data as percentages (%). CVD comorbidities and CVD events and their detection rates in different groups were compared using ANONA analysis and Chi-squared test. Spearman’s correlation coefficients between BF% and cardiometabolic abnormalities were calculated by partial correlation analysis. Multivariate logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for BF%, CVD comorbidities, and CVD events, adjusted for multiple confounders.

Results
Among the total 6,240 subjects who completed the study and had BMI and BF% data available, 3,086 had normal BMI. The prevalence of NWO was 16.36%, with 13.15% for men and 19.54% for women. With confounders adjusted, the risks of AO (OR = 6.05, 95%CI = 3.40–10.75), essential hypertension (OR = 1.56, 95%CI = 1.09–2.22), dyslipidemia (OR = 1.85, 95%CI = 1.49–2.29), and metabolic syndrome (OR = 4.61, 95%CI = 2.32–9.18) were significantly increased in the populations with NWO compared with the population without NWO (P < 0.05). BF% was not significantly associated with the risk of CVD events in the total (OR = 1.56, 95%CI = 0.83–2.93), male (OR = 1.00, 95%CI = 0.44–2.30), and female populations (OR = 2.53, 95%CI = 0.91–7.06).

Conclusion
NWO was found to be positively associated with CVD comorbidities but not with CVD events. The current study provides a ground to conduct further studies on whether body fat affects the risk of occurrence of CVD events and the underlying mechanisms in the future.
Views and opinions of the general public about the reimbursement of expensive medicines in the Netherlands
Authors: Scheijmans Féline E. V. , van der Wal Roosmarijn , Zomers Margot L. , van Delden Johannes J. M. , van der Pol W. Ludo , van Thiel Ghislaine J. M. W. 
Published: January 2025

Objectives
Solidarity-based healthcare systems are being challenged by the incremental costs of new and expensive medicines for cancer and rare diseases. To regulate reimbursement of such drugs, the Dutch government introduced a policy instrument known as the Coverage Lock (CL) in 2015. Little is known about the public opinion regarding such policy instruments and their consequences, i.e., reimbursement of some, but not all, expensive medicines. We aimed to identify the preferences of Dutch citizens regarding the reimbursement of expensive medicines, and to investigate the views of the public on the use of the CL as a healthcare policy instrument and their input for improvement.

Methods
Web-based survey of a representative sample of 1999 Dutch citizens aged 18 years and older (panel of research company Kantar Public). Potential respondents were approached via e-mail. Several policy measures, real-life cases and statements related to the CL were presented in the survey to respondents. Their responses were analysed by tabulating descriptive statistics (proportions and percentages).

Results
1179 individuals (response rate 59%) filled in the questionnaire. Although a majority considered the CL policy unjustified, they preferred it to the alternative policy measures that were presented. In four real-life case descriptions of patients in need of expensive medicines, respondents most often indicated effectiveness, lack of availability of alternative treatment and improved quality of life due to treatment as reasons for a positive reimbursement decision. An unfavourable cost-benefit ratio was their main reason to be against reimbursement. Some argued that withholding reimbursement was a way of informing manufacturers that extremely high prices are unacceptable.

Conclusion
There is public support for patients in need of expensive medicine. Many respondents supported the CL as a reimbursement policy. However, there is a wish to optimize the interpretation of the assessment criteria and the weight these are attributed in decision making about reimbursement of expensive innovative medicine for patients.
Factors associated with chronic kidney disease knowledge and preventive practices: An analytical cross-sectional study among patients with hypertension at Amana Regional Referral Hospital in Dar es Salaam, Tanzania
Authors: Ambikile Joel Seme , Ngulupi Shabani S. , Massae Agnes Fredrick 
Published: January 2025

Background
Globally, Chronic kidney Disease (CKD) has become a significant public health concern, with sub-Saharan Africa being among the populations experiencing the highest rates. Managing CKD poses a significant challenge due to its health complications and associated high cost of care. Hypertension is one of the leading causes of CKD, responsible for the decline in kidney function in patients. Knowledge and lifestyle modifications are pivotal to the prevention and progression of CKD. In Tanzania, little is known regarding CKD knowledge and preventive practices among patients with hypertension. Therefore, this study aimed to assess context-specific factors associated with CKD knowledge and preventive practices among patients with hypertension at Amana Regional Referral Hospital in Dar es Salaam.

Methods
An analytical cross-sectional study involving 184 patients was conducted at Amana Regional Referral Hospital. Patient were recruited at the outpatient hypertension clinic using simple random sampling in June and July 2022. Data analysis was conducted using IBM-SPSS Statistics version 25. Bivariate and multiple logistic regression analyses were performed to identify factors associated with knowledge and preventive practices related to CKD, with statistical significance set at a p-value < 0.05.

Results
The median CKD knowledge score was 13 (IQR: 9–16). Of the 184 respondents, 104 (56.5%) demonstrated high CKD knowledge. None of the sociodemographic factors were significantly associated with CKD knowledge. The median score for CKD preventive practices was 9 (IQR: 8–9), and 111 respondents (60.3%) had good practices. High CKD knowledge was significantly associated with good CKD preventive practices (AOR: 1.98; 95% CI: 1.08, 3.62; p = 0.027).

Conclusion
A significant proportion of hypertensive patients in this study exhibited both high CKD knowledge and good preventive practices. The positive correlation between CKD knowledge and improved preventive practices highlights the importance of educational interventions to further enhance CKD knowledge among patients with hypertension.
Men’s gender role and attitude toward sexual autonomy of women in India
Authors: Pradhan Manas Ranjan , De Prasenjit 
Published: January 2025

Objective
Sexual autonomy is essential to women’s empowerment and crucial to human rights. Measurement of women’s sexual autonomy from men’s perspective is rare in India, though critical for achieving the sexual and reproductive rights of women who continue to exhibit poor sexual and reproductive health (SRH) outcomes. The study assesses Indian men’s attitudes toward women’s sexual autonomy and associated factors using a nationally representative sample of men.

Methods
This study involved a total sample of 101,839 men aged 15–54 covered in the fifth round of the National Family Health Survey (2019–21). Descriptive statistics, bivariate analysis, and binary logistic regression were used to determine predictors of men’s favorable attitudes toward the sexual autonomy of women. All the statistical analyses were performed using Stata with a 5% significance level.

Results
Sixty-three percent of men hold a favorable attitude toward women’s sexual autonomy. Men’s support for women’s sexual autonomy was positively correlated with their egalitarian views on household decision-making (AOR: 1.45; CI: 1.41–1.49), higher educational attainment (AOR: 1.34; CI:1.20–1.50), currently married status, media exposure (AOR: 1.17; CI: 1.12–1.21), currently working status, and wealthier household strata (AOR: 1.17; CI: 1.11–1.23).

Conclusion
Results suggest promoting gender egalitarian norms through educational campaigns, community workshops held by local leaders, grassroots healthcare professionals, and non-governmental organizations, and broadening existing SRH strategies by including younger, non-literates, unmarried, unemployed, and rural men.
Obesity Is Independently Associated With Increased Risk of Fecal Incontinence and Altered Rectal Sensitivity
Authors: Lodhia Nayna A. , Hiramoto Brent , Horton Laura , Goldin Alison H. , Chan Walter W. 
Published: January 2025

INTRODUCTION:
Hindgut symptoms are poorly understood complications of obesity. The impact of obesity on fecal incontinence (FI) and anorectal physiology remains unclear, with inconsistent results in prior studies. We aimed to evaluate the relationship between obesity and FI, and the physiological changes in anorectal function.

METHODS:
This was a retrospective cohort study of consecutive adults who underwent high-resolution anorectal manometry (HRAM) at a tertiary center for anorectal symptoms. Demographics, clinical history, surgical/obstetric history, medications, and HRAM findings were reviewed. Patients were classified as nonobese (body mass index [BMI] <25 kg/m2), overweight (BMI 25–29.9 kg/m2), class I obesity (30–34.9 kg/m2), and class II + III obesity (>35 kg/m2). The Fisher exact/Student t test for univariate analyses and logistic/general linear regression for multivariable analyses were performed.

RESULTS:
A total of 552 adults were included. The mean BMI was higher among patients with FI (27.5 vs 25.9 kg/m2, P = 0.013). Compared with the nonobese group, FI was more prevalent in class II + III obesity (31.7% vs 13.2%, P = 0.0024), but not class I obesity or overweight groups. On multivariable analysis controlling for potential confounders, class II + III obesity (adjusted odds ratio 2.89, 95% confidence interval 1.28–6.50, P = 0.02) remained an independent risk factor of FI. Among patients with FI, both BMI (β-coefficient 1.09, P = 0.016) and class II + III obesity (β-coefficient 18.9, P = 0.027) independently predicted increased first rectal sensation volume on HRAM on multivariable regression.

DISCUSSION:
Classes II + III obesity was an independent risk factor of FI. Among patients with FI, increasing BMI and class II + III obesity were associated with altered rectal sensitivity. Anorectal function testing should be considered to help guide management of FI among patients with obesity.
Impact of Prior Biologic Exposure on Ozanimod Efficacy and Safety in the Phase 3 True North Clinical Trial
Authors: Sands Bruce E. , Rubin David T. , Loftus Edward V. , Wolf Douglas C. , Panaccione Remo , Colombel Jean-Frederic , Dignass Axel , Regueiro Miguel , Vermeire Severine , Afzali Anita , Lawlor Garrett , Ahmad Harris A. , Wu Hsiuanlin , Osterman Mark T. , Jain Anjali , D'Haens Geert 
Published: January 2025

INTRODUCTION:
Patients with ulcerative colitis (UC) and prior biologic failure may have reduced or delayed efficacy with subsequent advanced therapies. This analysis evaluated the efficacy and safety of ozanimod during the True North (TN) study and its open-label extension (OLE) in biologic-exposed patients with UC.

METHODS:
TN was a randomized, placebo-controlled 52-week trial (10-week induction, 42-week maintenance period). Eligible patients could enter the OLE. Clinical outcomes were assessed at TN week (W) 10 and W52 and OLE W46 and W94. Symptomatic efficacy was evaluated through induction and in the OLE until W94. Safety was assessed.

RESULTS:
This analysis included 376 biologic-exposed patients. In the placebo-controlled cohort, more ozanimod-treated patients achieved clinical response than placebo at W10 regardless of the number or type of prior biologics; patients who used 1 vs ≥2 prior biologics achieved higher efficacy rates. Efficacy rates were higher at W52 than W10 and were similar across subgroups regardless of the number or type of prior biologics. Significantly greater proportions of ozanimod vs placebo patients achieved symptomatic response by W5 (P = 0.0173) and symptomatic remission by W10 (P = 0.0207). Among biologic-exposed TN W10 ozanimod nonresponders who entered the OLE, 61% achieved symptomatic response with an extra 10 weeks of ozanimod treatment. Ozanimod efficacy was durable for ∼3 years of continuous treatment in biologic-exposed W52 clinical responders who entered the OLE. No new safety signals were observed.

DISCUSSION:
Ozanimod was effective and safe in biologic-exposed patients with UC, but these patients may require more time to respond to treatment. Clinical trial registry website and trial numbers: ClinicalTrials.gov, numbers NCT02435992 and NCT02531126.
Ischemic Jejunitis as a Late Complication of Roux-en-Y Gastric Bypass
Authors: Kimchy Alexandra , Khambaty Fatima , Marino Gustavo 
Published: January 2025

ABSTRACT
The rising prevalence of obesity has led to a substantial investment in the advancement of treatment options for the disease and its comorbid conditions including lifestyle, pharmacologic, and procedural interventions. In this study, we describe a patient with a history of Roux-en-Y gastric bypass who was diagnosed with ischemic jejunitis on upper endoscopy because of the development of an internal hernia, a known late complication of bariatric surgery. This case highlights the diagnostic utility of endoscopy in postgastric bypass complications and the need for safer alternatives to surgery that have the potential to achieve significant weight loss such as bariatric endoscopic therapies.