bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advancing Sustainability Assessment of Renewable Energy: A Study on Indicator‐to‐Framework Methods and Associated Rule Mining
Authors: Faraji Abdolmaleki Shoeib , Bello Bugallo Pastora M. 
Published: January 2025

ABSTRACTDivergent sustainable development perspectives, mathematical model limitations, and varying scenarios contribute to uncertainty in assessing renewable energy sustainability. To tackle these challenges, this study conducts a comprehensive literature review, employs an analogy, and utilizes knowledge discovery techniques with an indicator‐to‐framework approach. Qualitative classification and rule mining elucidate the interrelationships among dimensions, indicators, and scopes, enhancing assessment coherence. The study identifies 227 indicators across five dimensions and nine scopes, highlighting key rules through Apriori algorithm. Strong rules, meeting a support threshold of 0.22, confidence of 0.7, and Lift of 2.512, underscore the significance of environmental, economic, social, and technological dimensions. Environmental indicators like CO2 emissions, NOX emissions, and SO2 emissions feature prominently. The harmonization of dimensions, indicators, and scopes streamlines research and mitigates ambiguities. Appendices augment rules with frequent indicators, enriching insights. This data‐driven methodology provides a practical solution to the complexities of selecting appropriate indicators for such assessments.
Palmitate potentiates the SMAD3-PAI-1 pathway by reducing nuclear GDF15 levels
Authors: Montori-Grau Marta , Barroso Emma , Jurado-Aguilar Javier , Peyman Mona , Wahli Walter , Palomer Xavier , Vázquez-Carrera Manuel 
Published: January 2025

Abstract
Nuclear growth differentiation factor 15 (GDF15) reduces the binding of the mothers’ against decapentaplegic homolog (SMAD) complex to its DNA-binding elements. However, the stimuli that control this process are unknown. Here, we examined whether saturated fatty acids (FA), particularly palmitate, regulate nuclear GDF15 levels and the activation of the SMAD3 pathway in human skeletal myotubes and mouse skeletal muscle, where most insulin-stimulated glucose use occurs in the whole organism. Human LHCN-M2 myotubes and skeletal muscle from wild-type and Gdf15

−/−
mice fed a standard (STD) or a high-fat (HFD) diet were subjected to a series of studies to investigate the involvement of lipids in nuclear GDF15 levels and the activation of the SMAD3 pathway. The saturated FA palmitate, but not the monounsaturated FA oleate, increased the expression of GDF15 in human myotubes and, unexpectedly, decreased its nuclear levels. This reduction was prevented by the nuclear export inhibitor leptomycin B. The decrease in nuclear GDF15 levels caused by palmitate was accompanied by increases in SMAD3 protein levels and in the expression of its target gene SERPINE1, which encodes plasminogen activator inhibitor 1 (PAI-1). HFD-fed Gdf15
−/− mice displayed aggravated glucose intolerance compared to HFD-fed WT mice, with increased levels of SMAD3 and PAI-1 in the skeletal muscle. The increased PAI-1 levels in the skeletal muscle of HFD-fed Gdf15
−/− mice were accompanied by a reduction in one of its targets, hepatocyte growth factor (HGF)α, a cytokine involved in glucose metabolism. Interestingly, PAI-1 acts as a ligand of signal transducer and activator of transcription 3 (STAT3) and the phosphorylation of this transcription factor was exacerbated in HFD-fed Gdf15
−/− mice compared to HFD-fed WT mice. At the same time, the protein levels of insulin receptor substrate 1 (IRS-1) were reduced. These findings uncover a potential novel mechanism through which palmitate induces the SMAD3-PAI-1 pathway to promote insulin resistance in skeletal muscle by reducing nuclear GDF15 levels.
A computer vision system for recognition and defect detection for reusable containers
Authors: Wahyudi Vincent , Ziegler Cedric C. , Frieß Matthias , Schramm Stefan , Lang Constantin , Eberhardt Lars , Freund Fabian , Dobhan Alexander , Storath Martin 
Published: January 2025

Abstract
Small load carriers (SLCs) are standardized reusable containers used to transport and protect customer goods in many manufacturers. Throughout the life cycle of the SLCs, they will be collected, manually checked for defects (wear, cracks, and residue on the surface), and cleaned by specialized logistic companies. Human operators in small to medium-sized companies manually evaluate the defects due to the variety and degree of possible defects and varying customer needs. This manual evaluation is not scalable and prone to errors. This work aims to fill this gap by proposing a computer vision system that can recognize the SLC type for inventory management and perform defect detection automatically. First, we develop a camera portal, consisting of standard components, that capture the relevant surfaces of the SLC. A labeled dataset of 17,530 images of 34 different SLCs with their defect status was recorded using this camera portal. We trained a classification model (ConvNeXt) using our dataset to predict the different types of SLCs achieving 100% class prediction accuracy. For defect detection, we explore eight state-of-the-art (SOTA) anomaly detection models that achieved high rankings in the MVTec industrial anomaly detection benchmark. These models are trained using default hyperparameters and the two highest-scoring models were chosen and fine-tuned. The best-fine-tuned models based on “Area under the Receiver Operating Characteristic Curve (AUROC)” are PatchCore (0.811) and DRAEM (0.748). These results indicate that there is still potential for improvement in the automation of defect detection of SLCs.
Symmetry-induced ambiguity in orientation estimation from RGB images
Authors: Bertens Tijn , Caasenbrood Brandon , Saccon Alessandro , Jalba Andrei 
Published: January 2025

Abstract
The estimation of object orientation from RGB images is a core component in many modern computer vision pipelines. Traditional techniques mostly predict a single orientation per image, learning a one-to-one mapping between images and rotations. However, when objects exhibit rotational symmetries, they can appear identical from multiple viewpoints. This induces ambiguity in the estimation problem, making images map to rotations in a one-to-many fashion. In this paper, we explore several ways of addressing this problem. In doing so, we specifically consider algorithms that can map an image to a range of multiple rotation estimates, accounting for symmetry-induced ambiguity. Our contributions are threefold. Firstly, we create a data set with annotated symmetry information that covers symmetries induced through self-occlusion. Secondly, we compare and evaluate various learning strategies for multiple-hypothesis prediction models applied to orientation estimation. Finally, we propose to model orientation estimation as a binary classification problem. To this end, based on existing work from the field of shape reconstruction, we design a neural network that can be sampled to reconstruct the full range of ambiguous rotations for a given image. Quantitative evaluation on our annotated data set demonstrates its performance and motivates our design choices.
Effectiveness and cytokine profile of combined anti-vascular endothelial growth factor and corticosteroid therapy for chronic retinal vein occlusion
Authors: Arai Yusuke , Takahashi Hidenori , Inoda Satoru , Sakamoto Shinichi , Kawashima Hidetoshi , Yanagi Yasuo 
Published: January 2025

Abstract

Purpose
To investigate whether sub-Tenon injection of triamcinolone acetonide (STTA) combined with anti-vascular endothelial growth factor (VEGF) prolongs the recurrence intervals of macular edema (ME) for chronic retinal vein occlusion (RVO) and to investigate the differences in intraocular inflammatory cytokines between good responders (GRs) and non-responders (NRs).

Methods
This retrospective, observational study involved 42 eyes of 42 patients with ME due to chronic RVO who had received only anti-VEGF for ≥ 1 year and were transitioned to combination therapy. GRs were defined as patients whose recurrence intervals were prolonged by ≥ 2 weeks compared with patients receiving anti-VEGF alone. Moreover, immediately before starting the combined therapy, aqueous humor was collected and the following inflammatory cytokines were compared between GRs and NRs: CCL11, MCP-3, IP-10, CCL13, G-CSF, GM-CSF, IL-1α, IL-15, IL-4, M-CSF, MMP-9, TNF-α, MCP-1, CXCL-1, CXCL12, IL-8, galectin-1, IFN-γ, IL-12, IL-2, IL-6, MMP-1, PDGF-AA, and VEGF-A. These results were analyzed by nominal logistic regression after stepwise variable selection.

Results
There were 26 eyes (62%) in the GR group. Nominal logistic analyses showed that a higher concentration of IL-1α (P = 0.016) and lower concentrations of IL-5 (P = 0.015), IL-6 (P = 0.022), and galectin-1 (P = 0.015) were significantly associated with the extension of the time from injection to recurrence of ME.

Conclusion
Combined anti-VEGF and STTA therapy for chronic RVO was effective in 62% of patients, suggesting the effectiveness of STTA. Higher IL-1α and lower IL-5, IL-6, and galectin-1 were the factors associated with combined treatment effectiveness.
Energies Within Rock Mass and the Associated Dynamic Rock Failures
Authors: Watson John , Canbulat Ismet , Zhang Chengguo , Wei Chunchen 
Published: January 2025

Abstract
Catastrophic dynamic rock failure is one of the most challenging problems existing in the fields of civil tunneling and mining. It occurs in complex environments of geology, stress and excavation, and there is no one set of circumstances that is responsible for the phenomenon. However, a major contributing factor is believed to be energy storage and release. This paper studies and quantifies the energy release concept to advance the understanding and control of dynamic rock failures. The impacts of energy sources within rock masses on dynamic rock failures are assessed. The energy sources include strain and potential energy, the pressure energy of free and adsorbed gas and radiated seismic energy related to rock fracture or faulting. A new time-based coupled model is developed to estimate the ejection velocity when dynamic rock failures occur. Two burst scenarios are demonstrated using the proposed coupled model, i.e., a burst in the development heading of an unsupported face, and a ribside burst in a supported rib. The coupled model results show the superiority of bolts with a capacity for greater plastic elongation. Conveniently from the design perspective, maximum mesh tension is governed entirely by bolt capacity and mesh rupture strain. In addition, a rockburst hazard classification is proposed by examining a broad range of studies conducted in various disciplines to classify the relationship between injury severity and impact velocities. The hazard profile of dynamic rock failures caused by various mine layouts, structural domains, gas environments and geological sequences can then be estimated on the basis of the quantitative analysis.
Associations between bone material strength index and FRAX scores
Authors: Rufus-Membere Pamela , Anderson Kara B. , Holloway-Kew Kara L. , Kotowicz Mark A. , Diez-Perez Adolfo , Pasco Julie A. 
Published: January 2025

Abstract

Introduction
Impact microindentation (IMI) measures bone material strength index (BMSi) in vivo. However, its ability to predict fractures is still uncertain. This study aimed to determine the association between BMSi and 10 year fracture probability, as calculated by the FRAX algorithm.

Materials and methods
BMSi was measured using the OsteoProbe in 388 men (ages 40–90 yr) from the Geelong Osteoporosis Study. The probabilities for a major osteoporotic fracture (MOF) and hip fracture (HF) were calculated using the Australian FRAX tool. Hip (HF) and major osteoporotic (MOF) fracture probabilities were computed with and without the inclusion of femoral neck bone mineral density (BMD). For each participant, four 10 year probability scores were therefore generated: (i) HF-FRAXnoBMD; (ii) HF-FRAXBMD; (iii) MOF-FRAXnoBMD; (iv) MOF-FRAXBMD.

Results
BMSi was negatively correlated with age (r = − 0.114, p = 0.025), no associations were detected between BMSi and femoral neck BMD (r = + 0.035, p = 0.507). BMSi was negatively correlated with HF-FRAXnoBMD (r = − 0.135, p = 0.008) and MOF-FRAXnoBMD (r = − 0.153, p = 0.003).
These trends held true for HF-FRAXBMD (r = − 0.087, p = 0.094) and MOF-FRAXBMD (r = − 0.111, p = 0.034), but only the latter reached significance.

Conclusion
BMSi captures the cumulative effect of clinical risk factors in the FRAX algorithm, suggesting that it could provide additional information that may be useful in predicting risk of fractures. Further studies are warranted to establish its efficacy in predicting fracture risk.
Disentangling the neural underpinnings of response inhibition in disruptive behavior and co-occurring ADHD
Authors: Saraçaydın Gülhan , van Rooij Daan , Kleine-Deters Renee , Messchendorp Marieke , Naaijen Jilly , Penzol María José , Rosa Mireia , Aggensteiner Pascal-M. , Baumeister Sarah , Holz Nathalie , Banaschewski Tobias , Saam Melanie , Schulze Ulrike M. E. , Sethi Arjun , Craig Michael , Castro-Fornieles Josefina , Arango Celso , Walitza Susanne , Werhahn Julia , Brandeis Daniel , Franke Barbara , Ruisch I. Hyun , Buitelaar Jan K. , Dietrich Andrea , Hoekstra Pieter J. 
Published: January 2025

Abstract
While impaired response inhibition has been reported in attention-deficit/hyperactivity disorder (ADHD), findings in disruptive behavior disorders (DBDs) have been inconsistent, probably due to unaccounted effects of co-occurring ADHD in DBD. This study investigated the associations of behavioral and neural correlates of response inhibition with DBD and ADHD symptom severity, covarying for each other in a dimensional approach. Functional magnetic resonance imaging data were available for 35 children and adolescents with DBDs (8–18 years old, 19 males), and 31 age-matched unaffected controls (18 males) while performing a performance-adjusted stop-signal task. No significant association was found between behavioral performance and symptom severities. However, contrasting successful inhibition with failed inhibition revealed that DBD and ADHD symptom severity was associated with greater activation in the right inferior frontal regions and reduced activation in the bilateral striatal regions, respectively. During successful inhibition versus go-trials, ADHD symptom severity was associated with the left lateral occipital cortex activation. The contrast of failed inhibition versus go-trials revealed reduced activation in the right frontal and left parietal regions associated with DBD symptom severity while ADHD symptom severity was associated with bilateral precunei, dorsolateral prefrontal and left posterior parietal regions. Except for the right inferior frontal regions during successful versus failed inhibition, all clusters were also found to be inversely associated with the other dimension of interest (i.e., DBD or ADHD symptoms). Opposite direction of the associations between DBD and ADHD symptom severity, and fronto-parietal and fronto-striatal activation suggest unique contributions of DBD and ADHD to the neural correlates of response inhibition.
The effect of different timings of protein supplementation on variable outcomes in hemodialysis patients: a randomized clinical trial
Authors: Elsayed Mohamed Mamdouh , Elkazaz Amr Mohamed 
Published: January 2025

Abstract

Background
Oral nutritional supplements (ONS) are commonly prescribed to provide protein and energy to hemodialysis (HD) patients. There is a debate about the appropriate timing to administer ONS. We aimed to study the effect of different timings of ONS on variable outcomes in HD patients.

Methods
This research is a prospective, randomized, multicentric clinical trial (RCT) that included 120 patients on regular HD. Patients were allocated to receive ONS (25 gm protein powder/HD session) for 8 weeks either predialytic (1 h before the start of the session), intradialytic (2 h after the start of the session), or interdialytic (on non-dialysis days). Laboratory parameters, blood pressure (BP), dialysis adequacy, and nutritional parameters were assessed during the study.

Results
At study end, BP at the end of HD dropped significantly in the intradialytic group compared to the other groups (p < 0.001). Serum albumin improved significantly in the predialytic (p < 0.001) and intradialytic (p = 0.039) groups. The mean subjective global assessment score increased significantly in the interdialytic group (p = 0.040). The Kt/V and urea reduction ratio decreased significantly only in the intradialytic group (p value < 0.001 and 0.001). Serum sodium, potassium, phosphorus, cholesterol, triglycerides, and adverse events did not significantly differ between the different groups.

Conclusions
Predialytic ONS supplementation is a favorable option due to improved serum albumin with minimal effects on hemodynamics and dialysis adequacy compared to intradialytic and interdialytic supplementation.

Clinical Trials registration
ClinicalTrials.gov NCT05953636.
First registration date: 1/07/2023.
Epicardial adipose tissue, cardiac damage, and mortality in patients undergoing TAVR for aortic stenosis
Authors: Piña Pamela , Lorenzatti Daniel , Filtz Annalisa , Scotti Andrea , Gil Elena Virosta , Torres Juan Duarte , Perea Cristina Morante , Shaw Leslee J. , Lavie Carl J. , Berman Daniel S. , Iacobellis Gianluca , Slomka Piotr J. , Pibarot Philippe , Dweck Marc R. , Dey Damini , Garcia Mario J. , Latib Azeem , Slipczuk Leandro 
Published: January 2025

Abstract
Computed tomography (CT)-derived Epicardial Adipose Tissue (EAT) is linked to cardiovascular disease outcomes. However, its role in patients undergoing Transcatheter Aortic Valve Replacement (TAVR) and the interplay with aortic stenosis (AS) cardiac damage (CD) remains unexplored. We aim to investigate the relationship between EAT characteristics, AS CD, and all-cause mortality. We retrospectively included consecutive patients who underwent CT-TAVR followed by TAVR. EAT volume and density were estimated using a deep-learning platform and CD was assessed using echocardiography. Patients were classified according to low/high EAT volume and density. All-cause mortality at 4 years was compared using Kaplan-Meier and Cox regression analyses. A total of 666 patients (median age 81 [74–86] years; 54% female) were included. After a median follow-up of 1.28 (IQR 0.53–2.57) years, 11.7% (n = 77) of patients died. The EAT volume (p = 0.017) decreased, and density increased (p < 0.001) with worsening AS CD. Patients with low EAT volume (< 49cm3) and high density (≥-86 HU) had higher all-cause mortality (log-rank p = 0.02 and p = 0.01, respectively), even when adjusted for age, sex, and clinical characteristics (HR 1.71, p = 0.02 and HR 1.73, p = 0.03, respectively). When CD was added to the model, low EAT volume (HR 1.67 p = 0.03) and CD stages 3 and 4 (HR 3.14, p = 0.03) remained associated with all-cause mortality. In patients with AS undergoing TAVR, CT-derived low EAT volume, and high density were independently associated with increased 4-year mortality and worse CD stage. Only EAT volume remained associated when adjusted for CD.

Graphical Abstract
Progress report on multiple endocrine neoplasia type 1
Authors: Halperin Reut , Tirosh Amit 
Published: January 2025

Abstract
Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disorder caused by a germline pathogenic variant in the MEN1 tumor suppressor gene. Patients with MEN1 have a high risk for primary hyperparathyroidism (PHPT) with a penetrance of nearly 100%, pituitary adenomas (PitAd) in 40% of patients, and neuroendocrine neoplasms (NEN) of the pancreas (40% of patients), duodenum, lung, and thymus. Increased MEN1-related mortality is mainly related to duodenal-pancreatic and thymic NEN. Management of PHPT differs from that of patients with sporadic disease, as the surgical approach in MEN1-related PHPT includes near-total or total parathyroidectomy because of multigland hyperplasia in most patients and the consequent high risk of recurrence. NEN management also differs from patients with sporadic disease due to multiple synchronous and metasynchronous neoplasms. In addition, the lifelong risk of developing NEN requires special considerations to avoid excessive surgeries and to minimize damage to the patient’s function and well-being. This progress report will outline current insights into surveillance and management of the major clinical manifestation of MEN1 syndrome in children and adults with MEN1 diagnosis. In addition, we will discuss MEN1-like clinical presentation with negative MEN1-genetic workup and future clinical and research directions.
Development of molecular markers linked to quantitative trait loci and genes controlling endosperm-based hybridization barriers
Authors: Pinar Hasan , Mutlu Nedim , Aydin Hamide , Dönderalp Veysel , Şimşek Cansu , Doğan Selcen 
Published: January 2025

Abstract
According to the theory of biological species, two species are considered different if there exist barriers to reproduction that prevent genes from flowing between them. Despite the undervaluation of hybrid seed lethality in the field of evolutionary biology, it represents a significant and promising area of research within the discipline of plant breeding. It is of the utmost importance to gain an understanding of and to overcome hybrid seed failure in order to facilitate the incorporation of desired traits into cultivated species. In this study, hybrid seed lethality between Capsicum annuum L. (21A) and Capsicum frutescens L. (PI 281420) cross was investigated. A genetic map was constructed using an F2 population derived from a cross between C. annuum L. (21A) and C. frutescens L. (PI 281420). The quantitative trait loci (QTLs) for endosperm-based hybridization barriers were mapped using the F2 population. A genetic map with a total length of 929.6 centimorgans (cM) and comprising 12 linkage groups was constructed using 61 markers, including 31 sequence-related amplified polymorphism markers, 19 simple sequence repeat (SSR) markers, and 11 random amplified polymorphic DNA markers. The 2 linked QTLs related with endosperm-based hybridization barriers character were mapped on linkage groups 11 and XX. This research contributes to our understanding of the genetic processes that underpin hybrid seed lethality, thereby providing insights for the enhancement of cultivated plant species through breeding.