bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sub-differentiation of PI-RADS 3 lesions in TZ by advanced diffusion-weighted imaging to aid the biopsy decision process
Authors: Zhou Kun-Peng , Huang Hua-Bin , Bu Chao , Luo Zhong-Xing , Huang Wen-Sheng , Xie Li-Zhi , Liu Qing-Yu , Bian Jie 
Published: February 2023

BackgroundPerforming biopsy for intermediate lesions with PI-RADS 3 has always been controversial. Moreover, it is difficult to differentiate prostate cancer (PCa) and benign prostatic hyperplasia (BPH) nodules in PI-RADS 3 lesions by conventional scans, especially for transition zone (TZ) lesions. The purpose of this study is sub-differentiation of transition zone (TZ) PI-RADS 3 lesions using intravoxel incoherent motion (IVIM), stretched exponential model, and diffusion kurtosis imaging (DKI) to aid the biopsy decision process.MethodsA total of 198 TZ PI-RADS 3 lesions were included. 149 lesions were BPH, while 49 lesions were PCa, including 37 non-clinical significant PCa (non-csPCa) lesions and 12 clinical significant PCa (csPCa) lesions. Binary logistic regression analysis was used to examine which parameters could predict PCa in TZ PI-RADS 3 lesions. The ROC curve was used to test diagnostic efficiency in distinguishing PCa from TZ PI-RADS 3 lesions, while one-way ANOVA analysis was used to examine which parameters were statistically significant among BPH, non-csPCa and csPCa.ResultsThe logistic model was statistically significant (χ2 = 181.410, p&lt;0.001) and could correctly classify 89.39% of the subjects. Parameters of fractional anisotropy (FA) (p=0.004), mean diffusion (MD) (p=0.005), mean kurtosis (MK) (p=0.015), diffusion coefficient (D) (p=0.001), and distribute diffusion coefficient (DDC) (p=0.038) were statistically significant in the model. ROC analysis showed that AUC was 0.9197 (CI 95%: 0.8736-0.9659). Sensitivity, specificity, positive predictive value and negative predictive value were 92.1%, 80.4%, 93.9% and 75.5%, respectively. FA and MK of csPCa were higher than those of non-csPCa (all p&lt;0.05), while MD, ADC, D, and DDC of csPCa were lower than those of non-csPCa (all p&lt;0.05).ConclusionFA, MD, MK, D, and DDC can predict PCa in TZ PI-RADS 3 lesions and inform the decision-making process of whether or not to perform a biopsy. Moreover, FA, MD, MK, D, DDC, and ADC may have ability to identify csPCa and non-csPCa in TZ PI-RADS 3 lesions.
Pharmacovigilance on cannabidiol as an antiepileptic agent
Authors: Ammendolia Ilaria , Mannucci Carmen , Cardia Luigi , Calapai Gioacchino , Gangemi Sebastiano , Esposito Emanuela , Calapai Fabrizio 
Published: February 2023

Introduction: Cannabidiol (CBD) is an active chemical contained in the plant Cannabis sativa. It is a resorcinol-based compound that crosses the blood-brain barrier without causing euphoric effects. CBD has a plethora of pharmacological effects of therapeutic interest. CBD has been authorized in the European Union as an anticonvulsant against serious infantile epileptic syndromes, but its safety profile is still not sufficiently described.Methods: With the goal of expanding information on the safety of CBD use as an antiepileptic agent beyond the most common side effects known through clinical studies, an analysis of serious case reports on suspected adverse reactions (SARs) to CBD licensed as an anti-epileptic drug found in the EudraVigilance database is reported in this article. EudraVigilance is a system purchased by the European Medicines Agency (EMA) for monitoring the safety of medicinal products marketed in Europe.Results: The most frequent serious SARs to CBD in EudraVigilance were epilepsy aggravation, hepatic disorders, lack of efficacy, and somnolence.Discussion: Based on our analysis, the following precautions should be adopted for appropriate monitoring of potential adverse effects, more attention towards possible CBD medical use as an antiepileptic: awareness of interactions with other drugs, epilepsy aggravation, and drug effectiveness.
Shrub-mediated effects on soil nitrogen determines shrub-herbaceous interactions in drylands of the Tibetan Plateau
Authors: Cui Guangshuai , Pugnaire Francisco I. , Yang Liu , Zhao Wanglin , Ale Rita , Shen Wei , Luo Tianxiang , Liang Eryuan , Zhang Lin 
Published: February 2023

IntroductionShrub promotes the survival, growth and reproduction of understory species by buffering the environmental extremes and improving limited resources (i.e., facilitation effect) in arid and semiarid regions. However, the importance of soil water and nutrient availability on shrub facilitation, and its trend along a drought gradient have been relatively less addressed in water-limited systems.MethodsWe investigated species richness, plant size, soil total nitrogen and dominant grass leaf δ13C within and outside the dominant leguminous cushion-like shrub Caragana versicolor along a water deficit gradient in drylands of Tibetan Plateau.ResultsWe found that C. versicolor increased grass species richness but had a negative effect on annual and perennial forbs. Along the water deficit gradient, plant interaction assessed by species richness (RIIspecies) showed a unimodal pattern with shift from increase to decrease, while plant interaction assessed by plant size (RIIsize) did not vary significantly. The effect of C. versicolor on soil nitrogen, rather than water availability, determined its overall effect on understory species richness. Neither the effect of C. versicolor on soil nitrogen nor water availability affected plant size.DiscussionOur study suggests that the drying tendency in association with the recent warming trends observed in drylands of Tibetan Plateau, will likely hinder the facilitation effect of nurse leguminous shrub on understories if moisture availability crosses a critical minimum threshold.
Implementation model of data analytics as a tool for improving internal audit processes
Authors: Álvarez-Foronda Rubén , De-Pablos-Heredero Carmen , Rodríguez-Sánchez José-Luis 
Published: February 2023

IntroductionThe aim of this article is to understand the importance of internal audit departments todays—part of corporate governance and guardian of the organisation’s culture and climate—, as well as the opportunities that new technologies offer to increase their effectiveness and efficiency.MethodsTo this end, based on an exhaustive review of the literature, the concepts of internal audit and data analytics are related, and a framework is proposed for the implementation of a technology of these characteristics in an internal audit department.ResultsThe results of the research show that those companies that invest resources in readapting their processes to technological change are likely to obtain better results than those organisations that keep their management procedures obsolete.DiscussionBased on these results, it is concluded that there is a need to consider technological change in internal audit departments, specifically data analytics, to increase the effectiveness and efficiency of audit processes.
Physiological reactivity at rest and in response to social or emotional stimuli after a traumatic brain injury: A systematic review
Authors: Bodart Alice , Invernizzi Sandra , Lefebvre Laurent , Rossignol Mandy 
Published: February 2023

Numerous studies have shown that alterations in physiological reactivity (PR) after traumatic brain injury (TBI) are possibly associated with emotional deficits. We conducted a systematic review of these studies that evaluated PR in adults with moderate-to-severe TBI, either at rest or in response to emotional, stressful, or social stimuli. We focused on the most common measures of physiological response, including heart rate (HR), heart rate variability (HRV), respiratory sinus arrhythmia (RSA), electrodermal activity (EDA), salivary cortisol, facial electromyography (EMG), and blink reflex.MethodsA systematic literature search was conducted across six databases (PsycINFO, Psycarticles, SciencDirect, Cochrane Library, PubMed, and Scopus). The search returned 286 articles and 18 studies met the inclusion criteria.ResultsDiscrepancies were observed according to the type of physiological measure. Reduced physiological responses in patients with TBI have been reported in most EDA studies, which were also overrepresented in the review. In terms of facial EMG, patients with TBI appear to exhibit reduced activity of the corrugator muscle and diminished blink reflex, while in most studies, zygomaticus contraction did not show significant differences between TBI and controls. Interestingly, most studies measuring cardiac activity did not find significant differences between TBI and controls. Finally, one study measured salivary cortisol levels and reported no difference between patients with TBI and controls.ConclusionAlthough disturbed EDA responses were frequently reported in patients with TBI, other measures did not consistently indicate an impairment in PR. These discrepancies could be due to the lesion pattern resulting from TBI, which could affect the PR to aversive stimuli. In addition, methodological differences concerning the measurements and their standardization as well as the characteristics of the patients may also be involved in these discrepancies. We propose methodological recommendations for the use of multiple and simultaneous PR measurements and standardization. Future research should converge toward a common methodology in terms of physiological data analysis to improve inter-study comparisons.
Cost-effectiveness analysis of durvalumab plus chemotherapy as first-line treatment for biliary tract cancer
Authors: Ye Zhuo-miao , Xu Zhe , Li Huan , Li Qian 
Published: February 2023

ObjectiveThe TOPAZ-1 trial reported a significant survival benefit of durvalumab in combination with chemotherapy for the first-line treatment of biliary tract cancer (BTC). However, no studies have evaluated the economics of this treatment option. The aim of this study was to assess the cost effectiveness of durvalumab plus chemotherapy compared to placebo plus chemotherapy from the perspective of US and Chinese payers.MethodsBased on clinical data from the TOPAZ-1 trial, a Markov model was developed to simulate 10-year life expectancy and total healthcare costs for patients with BTC. The treatment group received durvalumab in combination with chemotherapy and the control group received placebo plus chemotherapy. The primary outcomes analyzed included quality-adjusted life years (QALYs) and incremental cost-effectiveness ratios (ICERs). Uncertainty in the analysis results was assessed by sensitivity analysis.ResultsFor US payers, the placebo plus chemotherapy group had a total cost of $56,157.05 and a utility of 1.10 QALYs, while the durvalumab plus chemotherapy group had a total cost of $217,069.25, a utility of 1.52 QALYs, resulting in an ICER of $381,864.39/QALY. For Chinese payers, the ICER of durvalumab plus chemotherapy group was $367,608.51/QALY. Sensitivity analysis showed that the analysis was most sensitive to the price of durvalumab. For US and Chinese payers, under the respective willing to pay thresholds, the likelihood of the durvalumab plus chemotherapy arm being cost-effective was 0%.ConclusionsBoth in China and in the US, durvalumab in combination with chemotherapy is not a cost-effective option for the first-line treatment of BTC compared with chemotherapy.
A case of severe leptospirosis with Jarisch–Herxheimer reaction presenting as respiratory failure
Authors: Shi Yunzhen , Guo Wanru , Hu Ming , Wang Yuxuan , Li Jingnan , Hu Wenjuan , Li Xiaomeng , Xu Kaijin 
Published: February 2023

BackgroundLeptospirosis is a widespread zoonotic disease caused by pathogenic Leptospira spp. The treatment of penicillin or tetracycline can cause a Jarisch–Herxheimer reaction (JHR), which can lead to acute respiratory distress syndrome (ARDS) and multi-organ failure in severe cases. The overall course of evolution and imaging features of a JHR exacerbation of leptospirosis have rarely been reported.Case presentationWe present a case of leptospirosis complicated by pulmonary alveolar hemorrhage and a Jarisch-Herxheimer reaction (JHR) that required respiratory and vasopressor support. This case demonstrates a well-defined course of evolution of JHR and the imaging features.ConclusionsLeptospirosis is easily misdiagnosed in some sporadic areas, and JHR complicates its management. Early diagnosis and appropriate treatment can reduce the mortality of severe leptospirosis with JHR.
Bioinformatics Analysis Reveals a Shared Pathway for Common Forms of Adult Nephrotic Syndrome
Authors: Li DengFeng , Liu Liang , Murea Mariana , Freedman Barry I. , Ma Lijun 
Published: February 2023

Key Points

Dysregulation of the focal adhesion pathway is present in the three most common forms of glomerular disease, that is, Focal segmental glomerulosclerosis, membranous nephropathy, and minimal change disease.Zyxin is seen to be upregulated in the glomerular compartment of patients with the three most common forms of glomerular disease.

Background
Focal segmental glomerulosclerosis, membranous nephropathy, and minimal change disease are common causes of nephrotic syndrome. Although triggers for these diseases differ, disease progression may share common molecular mechanisms. The aim of this study was to investigate the presence of molecular pathways that are dysregulated across these glomerular diseases.

Methods
The gene expression dataset GSE200828 from the Nephrotic Syndrome Study Network study was obtained from the Gene Expression Omnibus database. R and Python packages, Cytoscape software, and online tools (DAVID and STRING) were used to identify core genes and topologically relevant nodes and molecular pathways. Single-cell RNA sequencing analysis was applied to identify the expression patterns of core genes across kidney cell types in glomerular compartments.

Results
A total of 1087 differentially expressed genes were identified, including 691 upregulated genes and 396 downregulated genes, which are common in all three forms of nephrotic syndrome compared with kidney donor controls (FDR P<0.01). A multiapproach bioinformatics analysis narrowed down to 28 similarly dysregulated genes across the three proteinuric glomerulopathies. The most topologically relevant nodes belonged to the adherens junction, focal adhesion, and cytoskeleton pathways, where zyxin covers all of those gene ontology terms.

Conclusions
We report that dysregulation of cell adhesion complexes was present in the three most common forms of glomerular disease. Zyxin could be a biomarker in all three common forms of nephrotic syndrome. If further functional studies confirm its role in their development, zyxin could be a potential therapeutic target.
التعلم التنافسي الجماعي وتأثيره في تعلم مهارتي المناولة الطويلة بيد واحدة والطبطبة بتغير الاتجاه بكرة السلة
Authors: أ. م.د عماد طعمة راضي  , هناء عباس عبدالله  
Published: February 2023

قسم البحث على خمسة فصول : الباب الاول : تضمن المقدمة و واهمية البحث ومشكلة البحث قيد الدراسة واهداف البحث وهي معرفة مدى تأثير التعلم التنافسي الجماعي لتعلم مهارة المناولة الطويلة من فوق الكتف بكرة السلة , معرفة مدى تأثير التعلم التنافسي الجماعي لتعلم مهارة الطبطبة بتغير الاتجاه بكرة السلة , اما فروض البحث فهي :
- وجود فروق ذات دلالة احصائية بين نتائج الاختبارات القبلية ونتائج الاختبارات البعدية للمجموعتين التجريبية والضابطة لتعلم مهارة المناولة الطويلة بيد واحدة من فوق الكتف .
- وجود فروق ذات دلالة احصائية بين نتائج الاختبارات القبلية ونتائج الاختبارات البعدية للمجموعتين التجريبية والضابطة لتعلم مهارة الطبطبة بتغير الاتجاه .
- وجود فروق ذات دلالة احصائية بين نتائج الاختبارات البعدية لمجموعتين التجريبية والضابطة لتعلم مهارتي المناولة من فوق الكتف والطبطبة بتغير الاتجاه .
وتضمن المجالات البشرية والزمانية والمكانية .
اما الباب الثاني فتضمن التطرق الى اسلوب التعلم التنافسي الجماعي ومهارتي الطبطبة بتغير الاتجاه والمناولة الطويلة بيد واحدة من فوق الكتف .
اما الباب الثالث فتضمن منهج البحث وقد استخدم المنهج التجريبي وعينة البحث وهي من طلاب المرحلة الاولى بقسم التربية البدنية وعلوم الرياضة - الجامعة المستنصرية وبلغ عدد العينة ( 60 ) طالباً وقسمت على مجموعتين المجموعة التجريبية (30) طالباً والمجموعة الضابطة (30) طالباً وكذلك تضمن الادوات والوسائل التي استخدمت بالبحث والاختبارات المهارية والاسس العلمية للاختبارات والاختبارات القبلية وتضمن تطبيق اسلوب التعلم التنافسي الجماعي والاختبارات البعدية والوسائل الاحصائية.
اما الباب الرابع فقد تضمن عرض وتحليل ومناقشة النتائج الاختبارات القبلية والبعدية للمجموعتين التجريبية والضابطة للمهارتين المناولة الطويلة بيد واحدة من فوق الكتف والطبطبة بتغير الاتجاه .
اما الباب الخامس فتضمن الاستنتاجات والتوصيات التي توصل اليها الباحث وهي:
1- ان اسلوب التعلم التنافسي الجماعي له تأثير ايجابي في تعلم وتطوير مستوى الاداء المهاري في مهارتي المناولة الطويلة بيد واحدة من فوق الكتف والطبطبة بتغيير الاتجاه بكرة السلة .
2- اظهرت النتائج فاعلية اسلوب التنافسي الجماعي في تعلم مهارتي المناولة الطويلة بيد واحدة من فوق الكتف والطبطبة بتغير الاتجاه بكرة السلة.
اما التوصيات فتضمنت :
1- التأكيد على استخدام اسلوب التنافسي الجماعي لتعلم مهارتي المناولة الطويلة بيد واحدة من فوق الكتف والطبطبة بتغير الاتجاه .
2- اعتماد اسلوب التنافسي الجماعي الى جانب التدريس المتبع في تعلم المهارات بكرة السلة .
تأثير استراتيجية إدارة الوقت في تحسين بعض القدرات المهارية بكرة القدم
Authors: أ.د. نبيل عبد الوهاب العزاوي  , م . م . سعد عامر أسماعيل  
Published: February 2023

راعت الكثير من الدول أنظمة التربية والتعليم بصورة مركزة وذلك لما لها من أهمية في بناء مجتمعاتهم وتطورها وتقدمها نحو الأفضل فما نلحظه إن هناك تنافس قوياً فيما بين الدول المتقدمة التي تبحث عن الصدارة في شتى المجالات , وهذا يدلنا على أن تلك الدول قد أولت الإهتمام بالعملية التربوية والتعليمية وانتهجت الطرق الصحيحة والمتطورة والحديثة لكي تتحصل على تلك الصدارة ، فالطالب والمدرس والمنهج والمكان الذي تتم فيه عملية التدريس هي وحدة واحدة غير متجزأة فإن عانت إحدى هذه المحاور ضعف ضعفت بقية المحاور
FAKTOR-FAKTOR YANG MEMPENGARUHI TINDAKAN MASYARAKAT DALAM MEMBUANG SAMPAH RUMAH TANGGA DI DANAU SINGKARAK
Authors: Augia Trisfa , Akhila Lucy , Fitriyani  
Published: February 2023

Household waste is waste that comes from daily activities in the household. Garbage can cause environmental damage, a source of disease, and disrupt public health. Many rersidents of Jorong Ombilin live on the outskirts of Lake Singkarak and there are many community actions that dispose of household waste around the lake. This study aims to determine the factors that influence people's behavior in disposing of household waste in Lake Singkarak Jorong Ombilin in 2022. This research is a quantitative study with a cross-sectional design, which was conducted from February - September 2022 with a total sample of 90 respondents in Jorong Ombilin. Sampling using systematic random sampling technique. Data were processed using SPSS and analyzed using the chi square statistical test. The results showed that 67.8% of respondents took action to dispose of household waste in the lake, 58.9% had low level of education, 68.9% had bad knowledge, 56.7% had inadequate facilities, and 70.0% assume had inappropriate supervision. There is a correlation of variables of education (p=0.011), knowledge (p=0.000), availability of facilities (p=0.000), supervision (p=0.018) with community actions. Factors that have a significant relationship with community actions in disposing of household waste in Lake Singkarak Ombilin are the level of education, knowledge, availability of facilities, and supervision. It is recommended that the local government improve supervision of community actions and providing supporting facilities, create written regulation, and impose penalty of community actions in disposing of household waste.
Освітній менеджмент: тенденції ефективного використання технологій управління багатопрофільним закладом позашкільної освіти
Authors: Мосякова Ірина 
Published: February 2023

У статті окреслено сутність менеджменту, здійснено аналіз ефективного використання освітнього менеджменту в сучасному управлінні багатопрофільним закладом позашкільної освіти. Доведено, що менеджмент освітніх інновацій здійснюється за певними принципами, що постають як норми та орієнтири, зокрема: гуманізм, демократизм, національна спрямованість, єдність загальнолюдського і національного характеру навчання, співтворчість, життєтворчість, диференціація та індивідуалізація, оптимізація й відкритість, інноваційність.
У публікації висвітлено значимість і важливість управління багатопрофільним закладом позашкільної освіти, цілеспрямованої, активної взаємодії керівника з іншими учасниками освітнього процесу з метою забезпечення координації зусиль щодо оптимального функціонування установи та переведення її на більш якісний рівень.
Проаналізовано організаційний, інформаційний та комунікаційний аспекти структури управління багатопрофільним закладом позашкільної освіти. Визначено перспективу подальших досліджень у сфері формування нової управлінської культури, необхідної для управління багатопрофільним закладом позашкільної освіти; основні напрями розвитку освітнього менеджменту в системі позашкільної освіти.
Effects of Using Platelet-Rich Plasma (PRP) on the Healing of Achilles Tendon Rupture: An In Vivo Study
Authors: Seprianto  , Benni Raymond  , Tofrizal  , Rizki Rahmadian  
Published: February 2023

Background: Tendon healing is divided into several stages. After a tendon rupture, blood will collect and clot at the injury site, which is the hemorrhagic phase in tendon healing. Normally, platelets degranulate and release large amounts of cytokines and growth factors. Giving growth factors from outside, namely by platelet-rich plasma (PRP) in previous studies, was hypothesized to enhance the tendon repair process. This study is an exploratory study to determine the potential use of platelet-rich plasma (PRP) for the healing of Achilles tendon rupture in vivo studies.
Methods: In vivo post-test experimental study with the control group. A total of 12 rats were grouped into control and treatment. Assessment of healing of the Achilles tendon rupture was carried out by the histopathological score. Univariate and bivariate analyzes were carried out with the help of SPSS.
Results: The control group had higher scores for structure and fiber arrangement, nucleus shape, inflammation, and neovascularization than the treatment group. Likewise with the total histological score, where the control group had a higher total histological score than the treatment group, with p <0.05.
Conclusion: PRP administration did not have a better effect on the healing process of Achilles tendon rupture in vivo studies.
Ileocecal intussusception caused by appendiceal mucocele: case report.
Authors: Ramón-Baviera Martínez M , Artigues Sánchez de Rojas E , Oviedo Bravo JM , Beut Peris N , Santofimia Chordá R 
Published: February 2023

Resumen

La invaginación apendicular es una entidad poco frecuente que puede ocurrir a cualquier edad. Su diagnóstico puede resultar complejo debido a la sintomatología inespecífica. En la mayoría de los casos se realiza de forma intraoperatoria. El tratamiento suele ser quirúrgico, realizándose desde una apendicectomía hasta una hemicolectomía derecha.

Se presenta un caso clínico de un paciente varón de 29 años con invaginación ileocecal secundaria a un mucocele apendicular.