bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manipulation and obfuscation of financial reports
Authors: Lambertsen Nikolaj Niebuhr 
Published: February 2023

AbstractAnecdotally, not all investors are able to read and understand the financial report. I consider a strategic reporting game where investors are bounded rational and only pay attention to randomly sampled parts of the financial report and then extrapolate the value of the firm based on this. The manager can both obfuscate and bias the financial report. Obfuscation works by disaggregating the report into any number of line items, modeled as nonnegative signals, whose mean is constrained to be equal to the biased profitability of the firm. There can be synergies between biasing and obfuscation, causing financial statements to be both less transparent and more biased when investors are extrapolative.
Aquaporin 5 maintains lens transparency by regulating the lysosomal pathway using circRNA
Authors: Shaohua Hu , Yihui Wang , Kaier Zhang , Ying Bai , Xiaoyi Wang , Hui Zhao , Guohu Di , Peng Chen 
Published: February 2023

AbstractThe lens is transparent, non‐vascular, elastic and wrapped in a transparent capsule. The lens oppacity of AQP5−/− mice was increased more than that of wild‐type (AQP5+/+) mice. In this study, we explored the potential functional role of circular RNAs (circRNAs) and transcription factor HSF4 in lens opacity in aquaporin 5 (AQP5) knockout (AQP5−/−) mice. Autophagy was impaired in the lens tissues of AQP5−/− mice. Autophagic lysosomes in lens epithelial cells of AQP5−/− mice were increased compared with AQP5+/+ mice, based on analysis by transmission electron microscopy. The genetic information of the mice lens was obtained by high‐throughput sequencing, and then the downstream genes were analysed. A circRNA‐miRNA‐mRNA network related to lysosomal pathway was constructed by the bioinformatics analysis of the differentially expressed circRNAs. Based on the prediction of the TargetScan website and the validation by dual luciferase reporter assay and RNA immunoprecipitation‐qPCR, we found that circRNA (Chr16: 33421321‐33468183+) inhibited the function of HSF4 by sponging microRNA (miR‐149‐5p), and it downregulated the normal expression of lysosome‐related mRNAs. The accumulation of autophagic lysosome may be one of the reasons for the abnormal development of the lens in AQP5−/− mice.
Food safety considerations in the production of traditional fermented products: Japanese rice koji and miso
Authors: Allwood Joanne G. , Wakeling Lara T. , Post Laurie S. , Bean David C. 
Published: February 2023

AbstractWhile established in Asia, rice koji and miso are fermented foods that are becoming more popular in western countries. They have been shown to contain a variety of microorganisms, consisting of bacteria, yeasts, and fungal species. Many contemporary miso varieties are not pasteurized as consumers are looking for more natural products, and/or have the desire to consume fermented foods containing live microorganisms. While correctly prepared fermented foods are rarely associated with food safety outbreaks, incidences have been recorded. On these occasions, pathogenic, or spoilage microorganisms were introduced into the products from external sources such as the raw material or the processing environment. Consequently, hygiene and fermentation conditions need to be carefully monitored to ensure food safety. Furthermore, many of the production steps during koji and miso manufacture do not fit into contemporary food safety guidelines for foods. Although pH is a required food safety hurdle for fermented foods, this does not apply to nonacidic foods such as koji or miso. This review focuses on control of microbial pathogens and discusses the processes of miso fermentation, and how fermentation of rice koji and miso fits with current food safety hurdles in western countries.
An interview with IASB Chair Dr. Andreas Barckow
Authors: Street Donna L. , Gordon Elizabeth A. 
Published: February 2023

AbstractThis paper provides an overview of two interviews conducted with Andreas Barckow where he reflected on his outlook for the International Accounting Standards Board (IASB) and his role as Chair. The interviews included (1) a discussion of the IASB′s Third Agenda Consultation Feedback Statement, (2) key areas for future collaborations of the IASB and the International Association for Accounting Education and Research (IAAER) directed primarily at building the IASB's Research Capacity, (3) strategic challenges facing the IASB, (4) the formation of the International Sustainability Standards Board (ISSB) including the emerging model for the coexistence of the IASB and the ISSB and (5) the unique position the International Financial Reporting Standards Foundation holds as the only global organization to house both financial accounting reporting and sustainability disclosure standard‐setting boards. The interviews also addressed areas where the IAAER can encourage academic research to inform both the IASB and the IAASB and perhaps also the ISSB.
Carboniferous–Triassic tectonic and thermal evolution of the middle crust section of the Dervio–Olgiasca Zone (Southern Alps)
Authors: Real Christophe , Fassmer Kathrin , Carosi Rodolfo , Froitzheim Nikolaus , Rubatto Daniela , Groppo Chiara , Münker Carsten , Ferrando Simona 
Published: February 2023

AbstractA well‐preserved remnant of the middle crust of the former Adriatic passive margin is exposed in the Southern Alps (Italy). The Dervio–Olgiasca Zone is located south of the Insubric Line along the northern part of Como Lake and, because of the lack of Alpine overprint, provides favourable conditions to investigate the pre‐Alpine (rift‐related) history. We reconstruct the P–T–t–d evolution of the Adria middle crust through petrological (petrography, mineral chemistry, thermobarometry and thermodynamic modelling) and geochronological (Lu/Hf in garnet and U–Pb in monazite) data from pegmatites and host micaschists. These data allow reconstruction of a complex tectono‐thermal evolution of the future proximal Adriatic margin at the onset of Alpine rifting. The amphibolite‐facies Carboniferous metamorphic basement (7.6–10 kbar and 610–660°C at 318–312 Ma) was affected by pervasive extensional deformation (5.1–7.6 kbar and 580–660°C) in the Middle‐ to Late‐Permian (257.5 ± 3.8 Ma). Pegmatite intruded at 249.8 ± 1.1 Ma in an extensional phase that re‐equilibrated rocks of the basement at 3.5–4.5 kbar and 560–600°C. During the Middle‐ to Late‐Triassic (241–235 Ma), the basement experienced static thermal recrystallization (T = 689 ± 41°C and ~5.0 kbar). This Late‐Anisian to Early‐Carnian thermal event was simultaneous with the emersion of carbonate platforms, volcanism and ore deposition in the future proximal Adriatic margin. The subsequent cooling of the middle crust was synchronous with large‐scale extensional detachments developed in the upper crust (e.g., the Lugano‐Val Grande Fault), which controlled the formation of the Monte Generoso Basin. This study reveals that the local post‐Carboniferous thinning and heating events recorded in the Adriatic middle crust were interconnected to other processes occurring at different crustal levels that were, in turn, induced by crustal stretching in the early stages of the Alpine rifting.
Current status and problems in the diagnosis and treatment of premenstrual syndrome and premenstrual dysphoric disorder from the perspective of obstetricians and gynecologists in Japan
Authors: Yoshimi Kana , Inoue Fumi , Odai Tamami , Shirato Nahoko , Watanabe Zen , Otsubo Tempei , Terauchi Masakazu , Takeda Takashi 
Published: February 2023

AbstractAimTo investigate the current status and problems in the diagnosis and treatment of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) from the perspective of obstetricians and gynecologists (OB/GYNs) in Japan, the Japanese Society of Obstetrics and Gynecology (JSOG) conducted a national‐wide survey.MethodsAn email survey was sent to all JSOG members (16 732) and a web‐based survey was conducted using a Google form between September and November 2021. The current status and problems in PMS/PMDD diagnosis and treatment were surveyed in this cross‐sectional study.ResultsIn total, 1312 respondents (7.8% of all JSOG members) completed the questionnaire. In terms of diagnoses and treatment, OB/GYN was preferred over psychiatrist for PMS (91.4% vs. 45%); however, no differences were noted for PMDD (76.1% vs. 73.7%). A total of 1267 (96.6%) respondents engaged in routine PMS/PMDD treatment. Regarding the general diagnosis procedure, 84.4% respondents answered “only a vague medical interview,” 8.4% kept a two‐cycle symptom diary, and 10.3% used a screening questionnaire. The most commonly used medication was oral contraceptive pills (OCPs) (98.1%), followed by the Kampo, traditional Japanese herbal medicines, Kamishoyosan (73.6%). Concerning first‐line drugs for treatment, OCPs were the most common (76.8%), followed by Kampo medicine (19.5%); selective serotonin reuptake inhibitors (SSRIs) were less frequently used (2.6%). Regarding first‐line drugs among OCPs, 65.1% respondents reported drospirenone‐ethinylestradriol use.ConclusionsThis study indicates that only a few OB/GYNs practicing PMS/PMDD in Japan use a prospective diary, which is an essential diagnostic criterion for PMS/PMDD. Regarding treatment, SSRIs were used less frequently.
Risk of fractures and postfracture mortality in 3980 people with primary biliary cholangitis: A population‐based cohort study
Authors: Schönau Johanna , Wester Axel , Schattenberg Jörn M. , Hagström Hannes 
Published: February 2023

AbstractBackgroundMorbidity in primary biliary cholangitis (PBC) is multifactorial. Osteoporosis related to cholestasis is an extrahepatic complication of PBC. It is not fully established to what extent people with PBC have an increased risk for fractures, and if mortality after a fracture is increased, compared to the general population.MethodsAll Swedish people with PBC diagnosed between 2001 and 2016 were identified from the National Swedish Patient Register using ICD‐10 codes. Incident fractures were ascertained in the same register and compared to matched controls from the Swedish general population (1:10 for age, sex, and municipality). Cox regression was used to investigate the rates of fractures and postfracture mortality. The cumulative incidence of fractures was calculated while accounting for competing risks (death or liver transplantation).ResultsPeople with PBC (n = 3980) showed a higher risk of fractures at all‐time points during follow‐up compared to matched controls (n = 37,196), which was seen both in men and women. At 5 years of follow‐up, the cumulative incidence of any fracture in people with PBC was 16.8% (95% confidence interval [CI] = 15.6–18.1), compared to 11.6% (95%CI = 11.3–12.0) in controls. The rate of osteoporotic fractures was particularly high (adjusted Hazard ratio [aHR] = 1.9; 95% = CI 1.7–2.0). The 30‐day as well as the 1‐year mortality after a fracture was significantly higher in people with PBC compared to controls that also experienced a fracture (aHR = 2.2; 95%CI = 1.5–3.2; aHR = 2.0; 95%CI 1.7–2.4).ConclusionPeople with PBC have a significantly higher risk of fractures and postfracture mortality compared to matched controls from the general population.
The Utilization Profiles of Comprehensive School Mental and Behavioral Health Needs Among Adolescents*
Authors: Murphy Jennifer L. , Kim Youngmi 
Published: February 2023

ABSTRACTBACKGROUNDSchools have become a primary access point for mental health services to cover the gap between need and service utilization that has long existed, particularly among vulnerable populations. This study aims to identify the profiles of comprehensive school mental and behavioral health system (CSMBHS) needs and examine related characteristics.METHODSWe used the 2019 National Survey of Drug Use and Health (NSDUH) collected from a nationally representative sample in the United States. The sample included 6th through 12th‐grade adolescents who had received CSMBHS services in the last 12 months (N = 1346). The study conducted latent class analysis and multinomial logistic regression using Vermunt's 3‐step approach.RESULTSThe analysis identified 3 profiles of student CSMBHS service need: depression needs (42%), multiple endorsements in most needs (depressed, friend, and school problems; 6.5%), and low endorsement (51.4%). Findings suggest that the profiles differed by age, a lifetime major depressive episode, family income, and use of other mental health services.IMPLICATIONS FOR SCHOOL HEALTH, POLICY, PRACTICE, AND EQUITYEmphasis should be placed on proactively identifying student needs and advocating for appropriate interventions based on student needs.CONCLUSIONSThe study reveals important information regarding how schools best support students in need and in seeking services.
Effect of plasma transfusion on serum amyloid A concentration in healthy neonatal foals and foals with failure of transfer of passive immunity
Authors: Palmisano Megan , Javsicas Laura , McNaughten Justin , Gamsjäger Lisa , Renaud David L. , Gomez Diego E. 
Published: February 2023

AbstractBackgroundAnecdotal evidence suggests plasma transfusions increase serum amyloid A (SAA) concentrations in healthy neonatal foals making this marker of inflammation inappropriate for therapeutic decision making in such animals.Hypothesis/ObjectivesAdministration of hyperimmune fresh frozen plasma (FFP) increases SAA concentration in healthy foals and in foals with failure of transfer of passive immunity (FTPI).AnimalsEighty‐six healthy foals.MethodsProspective cohort study. Foals <24 hours of age receiving plasma transfusion for treatment of FTPI (serum immunoglobulin G [IgG] concentrations <8 g/L; n = 17) or as a preventative measure forRhodococcus equiinfection (IgG >8 g/L; n = 33) were enrolled. A healthy nontransfused group of foals (IgG >8 g/L; n = 21) also was included. Serum amyloid A concentration was determined before (t0h) and after (t24h) administration of FFP. Changes in blood SAA concentration were assessed using linear regression models.ResultsNo statistical differences were found in SAA concentration at t0h or t24h among the 3 groups (P > .05, for all comparisons). The variation in SAA concentration before (t0h) and after (t24h) plasma transfusion showed that administration of FFP was not associated with the changes in SAA concentration (P > .05). An association between SAA concentration at t0h and at 24 hours (P < .05) was identified, where foals with higher SAA concentration at t0h also had higher SAA concentration at t24h.Conclusions and Clinical ImportanceAdministration of FFP to newborn foals was not associated with changes in SAA concentration.
Pharmacokinetics of intra‐articular buprenorphine in horses with lipopolysaccharide‐induced synovitis
Authors: Castro‐Cuellar Gabriel , Cremer Jeannette , Queiroz‐Williams Patricia , Knych Heather K. , Leise Britta S. 
Published: February 2023

AbstractThe objective of this study was to describe the pharmacokinetics of intra‐articular (IA) administered buprenorphine in horses with lipopolysaccharide (LPS)‐induced synovitis. Radiocarpal synovitis was induced in six healthy adult horses with the IA injection of LPS (0.5 ng/joint) on two occasions in a randomized cross‐over design. Treatments (IA buprenorphine (IAB) at 5 μg/kg plus intravenous saline; and intravenous buprenorphine (IVB) at 5 μg/kg plus IA saline) were administered 4 h following LPS injection. Concentrations of buprenorphine were assessed in plasma and synovial fluid (SF) at 0.5, 2, 6, 12, and 24 h after administration. Pharmacokinetic parameters after IVB and IAB in plasma and synovial fluid were calculated using a nonlinear mixed effects model. IAB was detectable in SF of all horses at 24 h [median concentration of 6.2 (3.46–22.6) ng/mL]. IAB resulted in a median plasma concentration of 0.59 (0.42–1.68) ng/mL at 0.5 h and was detectable in all subjects for up to 6 h and in two horses for up to 12 h. IVB resulted in SF concentrations detected up to 6 h in all horses [median concentration of 0.12 (0.07–0.82) ng/mL]. Results suggest that IA buprenorphine remains present in the inflamed joint for at least 24 h and systemic absorption occurs.
Theorizing continuity and change in socialist regulation
Authors: Gillespie John 
Published: February 2023

AbstractHow does regulation change in authoritarian polities that tightly control public discourse and social mobilization? Socio‐legal theories assume that regulation changes through intersubjective dialogical exchanges that persuade regulators to alter how they perceive social problems and the appropriate regulatory responses. Although this framework captures regulatory change in transparent dialogical spaces, it misses much of the regulatory story in the opaque discursive processes that order authoritarian polities. This article turns to sociological institutional theory—a non‐dialogical theory to understand regulatory change in Vietnam's authoritarian polity. It investigates how commercial regulation in Vietnam has responded to an emerging mixed‐market economy, at the same time the state has suppressed public dialogical challenges to socialist ideology. It concludes that regulatory change occurs when regulators respond to economic and social crises and layer new ideational components onto old programmatic ideas, converting them to new uses.
Mapping of quantitative trait loci controlling cotton leaf curl disease resistance in upland cotton
Authors: Sattar Muhammad N. , Javed Muhammad , Hussain Syed B. , Babar Muhammad , Chee Peng W. , Iqbal Zafar , Munir Muhammad , Al‐Hashedi Sallah A. 
Published: February 2023

AbstractCotton leaf curl disease (CLCuD) is a major threat to cotton production in Asia and Africa. Using marker‐assisted breeding can be the best sustainable approach to tackle CLCuD. Identification of new QTLs in the indigenous cotton germplasm is necessary to combat CLCuD. The current study was designed to construct a genetic linkage map of bi‐parental F2:F3 populations developed from highly tolerant MNH‐886 and highly susceptible S‐12 cotton cultivars. One hundred seven CLCuD‐associated simple sequence repeat (SSR) marker alleles were identified as polymorphic and three new QTLs were found on chromosomes C11, C19 and C21. Two QTLs on chromosomes C11 and C19 were detected in both F2 and F3 populations in the region flanked by SSR markers CIR316 and BNL4094, and BNL285 and BNL3348, respectively. Whereas, one QTL on chromosome C21 was detected in the region flanked by SSR markers JESPR158 and JESPR135 in both F2 and F3 generations. The CLCuD‐associated QTLs identified in this study can help fine‐tune the molecular mapping of the QTLs on the cotton genome against CLCuD.
Initial symptoms of early‐onset dementia in Japan: nationwide survey
Authors: Edahiro Ayako , Okamura Tsuyoshi , Arai Tetsuaki , Ikeuchi Takeshi , Ikeda Manabu , Utsumi Kumiko , Ota Hidetaka , Kakuma Tatsuyuki , Kawakatsu Shinobu , Konagaya Yoko , Suzuki Kyoko , Tanimukai Satoshi , Miyanaga Kazuo , Awata Shuichi 
Published: February 2023

AimThe aim of this study was to investigate initial symptoms of early‐onset dementia (EOD) for each dementia subtype.MethodWe conducted a nationwide, population‐based EOD prevalence study in Japan. Data were collected through service providers for people with EOD. Initial symptoms were assessed in six domains: loss of memory, difficulty in word generation, irritability, loss of motivation, increased mistakes in the workplace or domestically, and unusual behaviours or attitudes other than those listed.ResultsParticipants were 770 people with EOD. Characteristic initial symptoms were observed for each EOD subtype. Loss of memory was more common in early‐onset Alzheimer's disease (75.7%, P < 0.001), difficulty in word generation was more common in early‐onset vascular dementia (41.3%, P < 0.001), and loss of motivation, increased mistakes in the workplace or domestically, and unusual behaviours or attitudes other than those listed were more common in early‐onset frontotemporal dementia (34.9%, P < 0.001; 49.4%, P < 0.001; 34.9%, P < 0.001, respectively). In addition, we observed gender differences whereby loss of memory was more common among women and irritability was more common among men. More than half of the participants were employed at symptom onset, and 57.2% of those who were employed at the onset had initial symptoms of increased mistakes in the workplace or domestically.ConclusionThis report reveals differences in the frequency of initial symptoms by EOD subtype. The results contribute to increasing public awareness of the initial symptoms of EOD, which will facilitate early diagnosis and social support.
Review of alternatives to antibiotic use in aquaculture
Authors: Bondad‐Reantaso Melba G. , MacKinnon Brett , Karunasagar Iddya , Fridman Sophie , Alday‐Sanz Victoria , Brun Edgar , Le Groumellec Marc , Li Aihua , Surachetpong Win , Karunasagar Indrani , Hao Bin , Dall'Occo Andrea , Urbani Ruggero , Caputo Andrea 
Published: February 2023

AbstractWith the rapid growth of the aquaculture production since the 1980s, there has been a concomitant increase in disease outbreaks. The injudicious and/or incorrect use of antimicrobial agents against diseases of farmed aquatic species poses a considerable threat to the development and growth of a successful and sustainable aquaculture industry. An increase in antimicrobial resistance (AMR) is an important consequence, resulting to the difficulty in treating common bacterial diseases in populations of aquatic organisms, combined with the presence of antibiotic residues in food fish and their products, leading to import refusals and negative impacts on international trade. To reduce the frequency of AMR, good aquaculture and effective biosecurity practices should include the prudent and responsible use of antibiotics and also consider the use of alternatives to antibiotics, in addition to disease prevention management. This article reviews the literature discussing the scope of the problem pertaining to antibiotic use, the emergence of AMR in aquaculture and to consider and discuss viable alternatives (e.g., vaccination, bacteriophages, quorum quenching, probiotics and prebiotics, chicken egg yolk antibody and medicinal plant derivative). We also discuss lessons learnt, from specific case studies such as the vaccination of farmed salmon in Norway and the use of ‘specific pathogen‐free’ seed—as primary and essential part of a biosecurity strategy.
Young Farmers in “The New World of Work”: The Contribution of New Media to the Work Engagement and Professional Identities*
Authors: Unay‐Gailhard İlkay , Brennan Mark A. 
Published: February 2023

AbstractThis study aims to explore the contribution of “The New World of Work” to farming, a career often viewed as unattractive among youth, and, as highlighted by the “young farmer problem” in the literature. This paper draws upon research on the role of “new ways of working” in work engagement and farmer identity among young farmers. A mixed‐method approach is used based on data from two Mediterranean Islands, Crete and Cyprus. Based on the polymedia‐ new theory of digital media, the study focuses both on new media use and new media engagement for work‐related tasks. Our findings highlight that the “The New World of Work” is an important phenomenon for initiating positive change toward cohesive social‐self in a career (subjective perception of a farming career concerning others). However, we identified binary terms used by farmers when explaining conflicts between cohesive self‐concept (expression of a strong sense of self regarding their farming career) and social‐self in a career. The study concludes that the duality between career self‐concepts and social‐self still holds patterns even among young generation farmers, regardless of their integration level to new media.