bluuebunny/crossref_metadata_2025_split huggingface dataset:
Einschätzung des Risikos für arzneimittelbezogene Probleme bei Pflegeheimbewohner*innen
Authors: Graeb Fabian , Jüttner Christian , Berger Bianca , Wolke Reinhold , Reißner Jana , Essig Gundula , Reiber Petra 
Published: December 2022

Zusammenfassung
Hintergrund
Polypharmazie und arzneimittelbezogene Probleme (AbP) stellen eine große Herausforderung bei der Betreuung und Behandlung von Pflegeheimbewohner*innen dar. Viele Interventionsstudien zeigen enttäuschende Ergebnisse, wodurch sich die Frage stellt, ob dies auch an der Auswahl der Zielparameter liegen könnte.

Material und Methoden
Mithilfe eines Routinedatensatzes aus 6 Langzeitpflegeeinrichtungen soll retrospektiv geprüft werden, ob der kürzlich validierte Medication Risk Score (MERIS) geeignet ist, in einer Population von Pflegeheimbewohner*innen eine Risikoeinschätzung vorzunehmen. Geprüft wurden Assoziationen zwischen MERIS und den abhängigen Variablen Klinikeinweisungen und Stürze über 12 Monate sowie ein Gewichtsverlust ≥ 5 % pro 3 Monate.

Ergebnisse
Von 495 Bewohner*innen weisen gemäß MERIS 38,6 % (n = 191) eine hohes Risiko für AbP auf. Eine univariate Regressionsanalyse erbrachte bei hohem MERIS ein signifikant erhöhtes Risiko für Krankenhauseinweisungen (OR 2,2; p < 0,001) und einen Gewichtsverlust ≥ 5 % pro 3 Monate (OR 1,95; p = 0,041), jedoch keine signifikante Assoziation mit Stürzen. In der multivariaten Regression steigt das Risiko für eine Krankenhauseinweisung mit einem Diabetes mellitus (OR 1,88; p = 0,004), erfolgtem Sturz im selben Zeitraum (OR 1,91; p = 0,001), positivem MERIS (OR 1,75; p = 0,006) und sinkt bei stabileren Gewichtsverläufen (OR 0,88; p = 0,004).

Diskussion
Die Ergebnisse deuten das Potenzial des Scores für zukünftige Forschungsprojekte und die individuelle Risikoeinschätzung an. Aufgrund der Einschränkungen bei retrospektiven Sekundäranalysen bedarf es aber weiterer Studien.
Multicenter cohort study on duration of antiarrhythmic medication for supraventricular tachycardia in infants
Authors: Mecklin Minna , Linnanmäki Anniina , Hiippala Anita , Leino Topias , Arola Anita , Leskinen Markku , Ruotsalainen Hanna , Happonen Juha-Matti , Poutanen Tuija 
Published: December 2022

AbstractAntiarrhythmic medication (AM) is commonly used to prevent supraventricular tachycardia (SVT) recurrence in infants. Our aim was to determine whether a shorter duration of AM is sufficient to prevent atrioventricular reentrant tachycardia (AVRT) recurrence and evaluate risk factors for recurrence of SVT after discontinued AM.This multicenter cohort study included all infants diagnosed with SVT in the five university hospitals in Finland between 2005 and 2017. Those diagnosed between 2005 and 2012 received AM for 12 months (group 1), and those diagnosed between 2013 and 2017 received AM for 6 months (group 2). A total of 278 infants presented with AVRT (group 1, n = 181; group 2, n = 97), and the median AM duration was 12.0 months (interquartile range [IQR] 11.4–13.4) and 7.0 months (IQR 6.0–10.2), respectively. Propranolol was the most frequently used first-line AM (92% and 95%). Recurrence-free survival rates were over 88% until 12 months after AM prophylaxis in both groups, without any statistically significant difference between them. Independent risk factors for recurrence of SVT after discontinuation of AM were need of combination AM (HR 2.2, 95% CI 1.14–4.20), Wolff-Parkinson-White (WPW) syndrome (HR 2.4, 95% CI 1.25–4.59), and age over 1 month at admission (HR 2.2, 95% CI 1.12–4.48). Conclusion: Shortening AM duration in infants from 12 to 6 months does not seem to lead to more frequent SVT recurrence. The risk factors for recurrence of SVT were WPW syndrome, need of combination AM, and age over 1 month.

What is Known:• Despite the evidence of spontaneous resolution of supraventricular tachycardia episodes in infants, the antiarrhythmic medication is often continued for up to twelve months.• The optimal approach for duration of antiarrhythmic medication remains unknown..

What is New:• Shortening the duration of antiarrhythmic medication in infants with supraventricular tachycardia does not seem to increase the risk of subsequent recurrence.• Infants whose arrhythmia was successfully controlled with monotherapy were the group least likely to have recurrence after discontinuation of antiarrhythmic medication.
Concerning the incorporation of potassium in the crystal structure of combeite (Na2Ca2Si3O9)
Authors: Kahlenberg Volker 
Published: December 2022

AbstractPotassium incorporation in the structure of combeite has been studied in detail. Since natural combeites are known to contain only small amounts of potassium focus was laid on the Na-rich part of a hypothetical solid-solution series with composition Na2-xKxCa2Si3O9. Samples were prepared from mixtures of silica and the corresponding carbonates for nominal compositions with x = 0.2, 0.3 and 0.5, heated from ambient temperature to 1350 °C and slowly cooled to 1000 °C. After disintegration of the carbonates, the platinum capsules used as sample containers were welded shut in order to avoid losses of the volatile K2O and Na2O components. From all three batches potassium containing combeite crystals could be retrieved. Single-crystal diffraction experiments revealed the following compositions: Na2.10(1)K0.11(1)Ca1.90(1)Si3O9, Na2.09(1)K0.18(1)Ca1.91(1)Si3O9 and Na2.13(1)K0.18(1)Ca1.87(1)Si3O9. Consistently, the trigonal crystals (space group P 31 2 1) contained (i) (K + Na):Ca ratios larger than 1:1 and (ii) potassium concentrations lower than those in the starting mixtures. Since the K-contents of the samples obtained from the runs with x = 0.3 and 0.5 were almost identical, the solid-solution seems to be rather limited with an upper boundary of about one potassium atom per unit cell. The structure of the K-containing combeites is very close to the K-free structures reported in the literature. It can be described as a mixed tetrahedral-octahedral network in which additional K, Na and Ca cations are incorporated for charge compensation. A detailed analysis of the topological features of the net is presented. From the six observed extra-framework sites only the M22 position showing a coordination environment with ten next oxygen neighbours is involved in the K-substitution. Potassium uptake is also reflected in increasing values for the lattice parameters a and c as well as the unit-cell volumes. Actually, the c-axis is more affected from the incorporation of the comparatively large K+-cations.
Life histories of Abies alba and Picea abies growing in old-growth forests driven by natural gap-phase dynamics
Authors: Paluch Jarosław , Jastrzębski Rafał 
Published: December 2022

AbstractWe analyzed growth trajectories recorded in the tree-ring series of Norway spruce Picea abies (L.) H. Karst. and silver fir Abies alba Mill. co-occuring with European beech Fagus sylvatica L. in old-growth forests driven by natural stand dynamics. The study sites were localized in five old-growth stands in the Western Carpathians (Central Europe). We characterized the life histories of 218 individual trees by using 25 metrics which refer to the age of the trees, number of release events, reaction to releases, radial increment and basal area increment. We found a large variation in the dbh-age relationship. The life histories of most trees included two or three (in single cases up to seven) release events. We did not find tree age as an important factor in determining post-release growth response. The maximal basal area increment was frequently registered at the terminal stage of tree life. The life histories of spruces and firs did not significantly differ. We concluded that in natural forests driven by gap-phase dynamics, the history of release events is the primary driver of tree growth and that tree age plays a secondary role. After reaching the overstory, trees can continue growing without significant symptoms of aging until extrinsic forces cause their death. Our results indicate that in the studied ecosystem the persistence of less shade-tolerant spruce is not attributable to the niche differentiation and site partitioning mechanism. An alternative hypothesis based on shifts in stand densities, species composition and climatic factors is more probable.
Stability of queueing-inventory systems with customers of different priorities
Authors: Otten Sonja , Daduna Hans 
Published: December 2022

AbstractWe study a production-inventory system with two customer classes with different priorities which are admitted to the system following a flexible admission control scheme. The inventory management is according to a base stock policy and arriving demand which finds the inventory depleted is lost (lost sales). We analyse the global balance equations of the associated Markov process and derive structural properties of the steady state distribution which provide insights into the equilibrium behaviour of the system. We derive a sufficient condition for ergodicity using the Foster-Lyapunov stability criterion. For a special case we show that the condition is necessary as well.
Covid-19 and mobile payment in Belgium: Closing the digital divide or just for the young, social, and impulsive?
Authors: Hellemans Johan , Willems Kim , Brengman Malaika 
Published: December 2022

AbstractExperts and industry reports agree that the COVID-19 crisis spurred the adoption of new retail technologies, like mobile payment. However, empirical academic evidence that compares their adoption and usage before, during, and after the crisis remains scarce. So far, academic mobile payment research has focussed almost entirely on the different building blocks of technological acceptance models, like perceived usefulness and ease of use, and their role in explaining intention to use. We need to learn more about the profile of the actual user. In this Belgian study, we investigate the evolution in mobile adoption based on survey data from 2019 to 2020 (2019: N = 897; 2020: N = 895). We examine differences in the profile of mobile payers in terms of their socio-demographics, retail, and social media behaviours. The pandemic triggered a clear uplift in mobile payment users between 2019 to 2020. Nonetheless, striking differences in socio-demographic profile and retail patronage remain. Our data shows that there is still inequality in adoption, related to age and social grade. We also observe a clear association between general impulse buying tendency and mobile payment. The link between internet/online shopping and mobile payment is firmly established. Finally, mobile adoption is related to the use of Instagram and Facebook. Consequences for retailers, researchers and public officers are further discussed.
Rapid One-Pot Microwave Assisted Green Synthesis Nitrogen Doped Carbon Quantum Dots as Fluorescent Precursor for Estimation of Modafinil as Post-Covid Neurological Drug in Human Plasma with Greenness Assessments
Authors: Salman Baher I. , Hassan Ahmed I. , Hassan Yasser F. , Saraya Roshdy E. , Batakoushy Hany A. 
Published: December 2022

AbstractThe neuro-stimulant anti-narcoleptic drug as modafinil (MOD) is used to treatment neurological conditions caused by COVID-19. MOD was used to treatment narcolepsy, shift-work sleep disorder, and obstructive sleep apnea-related sleepiness. So, an innovative, quick, economical, selective, and ecologically friendly procedure was carried out. A highly sensitive N@CQDs technique was created from green Eruca sativa leaves in about 4 min using microwave synthesis at 700 w. The quantum yield of the synthesized N@CQDs was found to be 41.39%. By increasing the concentration of MOD, the quantum dots' fluorescence intensity was gradually quenched. After being excited at 445 nm, the fluorescence reading was recorded at 515 nm. The linear range was found to be in the range 50 – 700 ng mL−1 with lower limit of quantitation (LOQ) equal to 45.00 ng mL−1. The current method was fully validated and bio analytically according to (US-FDA and ICH) guidelines. Full characterization of the N@CQDs has been conducted by high resolution transmission electron microscope (HRTEM), Zeta potential measurement, fluorescence, UV–VIS, and FTIR spectroscopy. Various experimental variables including pH, QDs concentration and the reaction time were optimized. The proposed study is simply implemented for the therapeutic drug monitoring system (TDMS) and various clinical laboratories for further pharmacokinetic research.
Isomorphous Substitution of Gallium into MFI-Framework Zeolite Increases 2,5-Dimethylfuran to Aromatics Selectivity and Suppresses Catalyst Deactivation
Authors: Sauer Christopher , de Reijer Guido J. L. , Schaefer Andreas , Carlsson Per-Anders 
Published: December 2022

AbstractThe valorization of biomass-derived molecules into commodity chemicals is important for the transition to renewable feedstocks. The model platform molecule 2,5-dimethylfuran (2,5-dmf) can be converted into value-added aromatics such as benzene, toluene, and xylenes (BTX) over zeolite catalysts. To explore the role of the zeolite acid site(s) in BTX selectivity, gallium has been isomorphously substituted into the framework, resulting in a Ga-silicate. Compared to the ZSM-5 counterpart, this modification shows enhanced benzene selectivity as well as resistance to deactivation by coke in continuous catalytic performance tests.
Frequency of thoracic recurrence based on pathological features in patients with ovarian epithelial tumors in stage I versus higher stages
Authors: Matsutani Hiroki , Nakai Go , Fujiwara Satoe , Takahashi Satoru , Yamamoto Kazuhiro , Ohmichi Masahide , Osuga Keigo 
Published: December 2022

Abstract
Purpose
The aim of this study was to clarify the frequency of thoracic recurrence and identify associated pathological features in postoperative patients with borderline or malignant ovarian epithelial tumors (BMOT) in stage I versus higher stages.

Materials and methods
A total of 368 consecutive patients with a single primary BMOT were treated at our hospital. This study included the 217 patients with no residual disease on the first CT after standard treatment. The timing and pattern of recurrence on follow-up CT images with a scan range from chest to pelvis were evaluated retrospectively. Patient characteristics, tumor histology, and stage were recorded from electronic medical records.

Results
After a median follow-up period of 48 months, recurrence was detected by CT in 9 patients in stage I (n = 159) and 15 in stage II/III (n = 58) (p = 0.0001). Thoracic recurrence was detected in four patients in stage I and four in stage II/III (p = 0.15). Abdominal recurrence was identified as a factor associated with thoracic recurrence (P < 0.001). Clear cell carcinomas accounted for three out of four thoracic recurrences in stage I and two out of four in stage II/III, and had the highest rates of thoracic recurrence (7.7% in stage I and 22.2% in stage II/III) among all histological types associated with thoracic recurrence. Among patients with recurrence, thoracic recurrence-free probability (p = 0.38), median abdominal recurrence-free interval (18 vs 16 months; p = 0.55) and thoracic recurrence-free interval (16.5 vs 23 months; p = 0.89) did not differ significantly between stage I and stage II/III.

Conclusion
The frequency and timing of thoracic recurrence did not differ significantly in postoperative patients with BMOT in stage I versus stage II/III. Abdominal recurrence and a histological type of clear cell carcinoma were most often associated with thoracic recurrence in stage I.
Flash flooding hazard assessment, modeling, and management in the coastal zone of Ras Ghareb City, Gulf of Suez, Egypt
Authors: Arnous Mohamed O. , El-Rayes Ahmed E. , El-Nady Habash , Helmy Ahmed M. 
Published: December 2022

AbstractThe assessment of flash flood hazards in the coastal zone of Ras Ghareb City (RGC), Red Sea, Egypt, was accomplished through the use of GIS tools and the spatial multi-criteria approach. The presented work aims to assess, integrate, and generate potential flash flood hazard maps. The analytic hierarchy process was utilized to calculate weights of hazard and vulnerability of flash flood controlling factors and their parameters such as topographical, geological, and hydrological factors. In addition, the risk degree of each specific basin and its sub-basins is estimated by combining standardized parameter values. Despite its location in an arid region, the basin may receive a large amount of rainwater, which can cause flash floods at the basin's outlet. Recently, flash flooding took place in the coastal region of RGC in October 2016 and September 2020, resulting in the loss of many human lives and catastrophic effects on local infrastructure and surrounding environments. According to reports from Hurghada, Red Sea Governorate, the RGC experienced exceptional flooding that exceeded 120 million cubic meters as a result of 51 mm of rainfall. Based on the remote sensing satellite data such as Aster Digital Elevation Model (GDEM) and the GIS tools, the basin and sub-basin drainage patterns were delineated and compared with reference topographical map sheets of a scale of 1: 50,000. The sub-basins have been isolated and morphometrically studied to determine vulnerability to flash flooding. In addition, the flash flood threat model was developed using geoprocessing tools provided by ArcGIS software to incorporate all contributing factors spatially. The flash flood risk in the Ras Ghareb (RG) basins and their sub-basins has been identified and classified into three classes (high, medium, and low hazard degree). High and moderate flood-risk basins require comprehensive studies to introduce measures to protect certain areas from flood danger. Finally, the GIS and the spatial multi-criteria analyses were effective ways to carry out a flash flood management system in order to support the decision-makers by recommendations to conserve and mitigate the possible flash flood hazards in the study areas.
Long-term safety profile of tirabrutinib: final results of a Japanese Phase I study in patients with relapsed or refractory B-cell malignancies
Authors: Munakata Wataru , Ando Kiyoshi , Yokoyama Masahiro , Fukuhara Noriko , Yamamoto Kazuhito , Fukuhara Suguru , Ohmachi Ken , Mishima Yuko , Ichikawa Satoshi , Ogiya Daisuke , Aoi Arata , Hatsumichi Masahiro , Tobinai Kensei 
Published: December 2022

AbstractTirabrutinib is a Bruton’s tyrosine kinase inhibitor for treating B-cell malignancies. We report the final results of a Phase I study of tirabrutinib in 17 Japanese patients with B-cell malignancies. Patients were administered tirabrutinib at a dose of 160 mg, 320 mg, or 480 mg once daily, or 300 mg twice daily (N = 3, 3, 4, and 7, respectively). Three patients continued tirabrutinib until study completion (November 30, 2020). Adverse events (AEs) occurred in all 17 patients, with Grade 3–4 AEs in 8 (47.1%), serious AEs in 7 (41.2%), drug-related AEs in 16 (94.1%), and Grade 3–4 drug-related AEs in 6 (35.3%). Drug-related AEs reported in 3 or more patients were rash, vomiting, neutropenia, arthralgia, and malaise. One additional serious AE (benign neoplasm of the lung, unrelated to tirabrutinib) occurred after the previous data cutoff (January 4, 2018). Tirabrutinib administration and response assessment were continued for over 4 years in 4 patients. The overall response rate was 76.5% (13/17 patients). The median (range) time to response and duration of response were 0.9 (0.9–5.9) months and 2.59 (0.08–5.45) years, respectively. These findings demonstrate the long-term safety and efficacy of tirabrutinib in Japanese patients with B-cell malignancies.Clinical trial registration: JapicCTI-142682 (http://www.clinicaltrials.jp/).
A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals
Authors: Novello Manuele , Bosman Laurens W. J. , De Zeeuw Chris I. 
Published: December 2022

Abstract
The cerebellum is involved in many motor, autonomic and cognitive functions, and new tasks that have a cerebellar contribution are discovered on a regular basis. Simultaneously, our insight into the functional compartmentalization of the cerebellum has markedly improved. Additionally, studies on cerebellar output pathways have seen a renaissance due to the development of viral tracing techniques. To create an overview of the current state of our understanding of cerebellar efferents, we undertook a systematic review of all studies on monosynaptic projections from the cerebellum to the brainstem and the diencephalon in mammals. This revealed that important projections from the cerebellum, to the motor nuclei, cerebral cortex, and basal ganglia, are predominantly di- or polysynaptic, rather than monosynaptic. Strikingly, most target areas receive cerebellar input from all three cerebellar nuclei, showing a convergence of cerebellar information at the output level. Overall, there appeared to be a large level of agreement between studies on different species as well as on the use of different types of neural tracers, making the emerging picture of the cerebellar output areas a solid one. Finally, we discuss how this cerebellar output network is affected by a range of diseases and syndromes, with also non-cerebellar diseases having impact on cerebellar output areas.
Influence of co-substrate existence, temperature, pH, and salt concentration on phenol removal, desalination, and power generation using microbial desalination cells
Authors: Safwat S. M. , Meshref M. N. A. , Salama M. , Elawwad A. 
Published: December 2022

AbstractMicrobial desalination cells (MDCs) exhibited an economical value with large promises as a useful desalination treatment solution. MDCs threefold applications to efficiently treat wastewater and to produce electricity and simultaneously accomplish desalination were investigated in this work. The study examined the influence of various performance parameters including co-substrate, temperature, pH, and salt concentrations on the response of three-chamber MDCs with respect to energy recovery and contaminant removal (Phenol). The system evaluation criteria encompassed chemical oxygen demand (COD), phenol removal efficiency, Coulombic efficiency, desalination efficiency, and other system parameters such as voltage generation and power density. The maximum COD and phenol removal efficiencies obtained at temperature = 37 °C, pH = 7, and salt concentration = 10,000 ppm, were 80% and 74%, respectively. The maximum Coulombic efficiency was 5.3% and was observed at temperature = 18 °C, pH = 7, and salt concentration = 10,000 ppm. The results show that the presence of a co-substrate improved power density; the maximum power density obtained was 52.9 mW/m2. The principal component analysis elucidated the impact of pH on COD and phenol removal rates. With our findings confirmed trends in the improvement of the voltage generation, COD and phenol removal efficiencies with the addition of a co-substrate, the temperature and pH increase.