EAACIMolecular Allergology User's Guide 2.0
Authors: Dramburg Stephanie , Hilger Christiane , Santos Alexandra F. , de las Vecillas Leticia , Aalberse Rob C. , Acevedo Nathalie , Aglas Lorenz , Altmann Friedrich , Arruda Karla L. , Asero Riccardo , Ballmer‐Weber Barbara , Barber Domingo , Beyer Kirsten , Biedermann Tilo , Bilo Maria Beatrice , Blank Simon , Bosshard Philipp P. , Breiteneder Heimo , Brough Helen A. , Bublin Merima , Campbell Dianne , Caraballo Luis , Caubet Jean Christoph , Celi Giorgio , Chapman Martin D. , Chruszcz Maksymilian , Custovic Adnan , Czolk Rebecca , Davies Janet , Douladiris Nikolaos , Eberlein Bernadette , Ebisawa Motohiro , Ehlers Anna , Eigenmann Philippe , Gadermaier Gabriele , Giovannini Mattia , Gomez Francisca , Grohman Rebecca , Guillet Carole , Hafner Christine , Hamilton Robert G. , Hauser Michael , Hawranek Thomas , Hoffmann Hans Jürgen , Holzhauser Thomas , Iizuka Tomona , Jacquet Alain , Jakob Thilo , Janssen‐Weets Bente , Jappe Uta , Jutel Marek , Kalic Tanja , Kamath Sandip , Kespohl Sabine , Kleine‐Tebbe Jörg , Knol Edward , Knulst André , Konradsen Jon R. , Korošec Peter , Kuehn Annette , Lack Gideon , Le Thuy‐My , Lopata Andreas , Luengo Olga , Mäkelä Mika , Marra Alessandro Maria , Mills Clare , Morisset Martine , Muraro Antonella , Nowak‐Wegrzyn Anna , Nugraha Roni , Ollert Markus , Palosuo Kati , Pastorello Elide Anna , Patil Sarita Ulhas , Platts‐Mills Thomas , Pomés Anna , Poncet Pascal , Potapova Ekaterina , Poulsen Lars K. , Radauer Christian , Radulovic Suzana , Raulf Monika , Rougé Pierre , Sastre Joaquin , Sato Sakura , Scala Enrico , Schmid Johannes M. , Schmid‐Grendelmeier Peter , Schrama Denise , Sénéchal Hélène , Traidl‐Hoffmann Claudia , Valverde‐Monge Marcela , van Hage Marianne , van Ree Ronald , Verhoeckx Kitty , Vieths Stefan , Wickman Magnus , Zakzuk Josefina , Matricardi Paolo M. , Hoffmann‐Sommergruber Karin 
Published: April 2023

AbstractSince the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE‐mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well‐defined, highly pure molecules for component‐resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state‐of‐the‐art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.