bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attachment and trauma-informed programme to support forcibly displaced parents of youth in Sweden: feasibility and preliminary outcomes of theeConnect Onlineprogramme
Authors: Kristen Anna , Salari Raziye , Moretti Marlene , Osman Fatumo 
Published: August 2023

ObjectivesTo assess the feasibility, acceptability and the impact of an online parenting programme for forcibly displaced parents of adolescents.DesignThe study was a single-arm feasibility study using pre-intervention post-intervention and follow-up assessments.SettingParticipants were recruited from municipality-based activities for refugee parents in a small city in the south of Sweden.ParticipantsParticipants were forcibly displaced parents (n=23; 47.8% maternal figures) of youth (n=23; 8–17 years old; 26.1% female) from Syria, Afghanistan and Somalia participating in an online parenting programme (eConnect).InterventioneConnectis an attachment-based and trauma-informed parenting intervention and was delivered over the course of 10 weekly sessions.Primary and secondary outcome measuresFeasibility was assessed by programme enrolment, attendance, completion and acceptability of the online platform and cultural fit of the programme. Primary outcome measures were programme impact on youth mental health problems. Secondary outcome measures were programme impact on family functioning and parent–child attachment insecurity.ResultsTheeConnectprogramme was highly feasible in terms of overall enrolment (100%), attendance (89.6%) and retention rates (100%). The online platform was acceptable, with mixed feedback primarily related to the access and usage of technology. Cultural fit of the programme was acceptable. Youth mental health problems (η2=0.29) and family functioning significantly improved (η2=0.18) over the course of the programme. Unexpectedly, parent reports of youth attachment insecurity significantly worsened (η2=0.16).ConclusionsThe findings suggest that the online delivery ofConnectwas a promising way to reduce barriers to service access and improve mental health problems and family functioning among forcibly displaced parents and their children during COVID-19. Future research is needed to explore the acceptability and impact of this programme post-COVID-19, and to develop culturally tailored and psychometrically sound measures for parent and youth reports of attachment.
Operations for D-Algebraic Functions
Authors: Tabuguia Bertrand Teguia 
Published: August 2023

A function is differentially algebraic (or simply D-algebraic) if there is a polynomial relationship between some of its derivatives and the indeterminate variable. Many functions in the sciences, such as Mathieu functions, the Weierstrass elliptic functions, and holonomic or D-finite functions are D-algebraic. These functions form a field, and are closed under composition, taking functional inverse, and derivation. We present implementation for each underlying operation. We also give a systematic way for computing an algebraic differential equation from a linear differential equation with D-finite function coefficients.
Each command is a feature of our Maple package NLDE available at https://mathrepo.mis.mpg.de/DAlgebraicFunctions/NLDEpackage.
Natural Anthraquinones as Promising MAPK3 Inhibitors for Complementary Cancer Therapy
Authors: Vaziri-Amjad Samaneh , Moradi-Najmi Massoud , Taherkhani Amir 
Published: August 2023

Objective. MAPK3 activates several nuclear transcription factors, including c-Jun and c-fos, by phosphorylating its downstream cytoplasmic protein, thereby contributing to cell proliferation and survival. Different carcinomas’ initiation, progression, cancer cell metastasis, and drug resistance have been associated with MAPK3 overexpression. Given the need for new and potent MAPK3 inhibitors, this study aimed to explore the potential of anthraquinones (AQs) as organic compounds capable of inhibiting MAPK3. Methods. Using AutoDock 4.0 software, the binding affinity of 21 AQs to the receptor’s active site was evaluated. AQs were ranked based on their ΔGbinding values to the receptor’s active site, with the highest rankings receiving the most favorable scores. The Discovery Studio Visualizer tool was used to demonstrate the interaction modes between the highest-ranked AQs and the MAPK3 catalytic site. Furthermore, a 100-nanosecond molecular dynamics (MD) computer simulation was performed to assess the stability of the docked pose of the most potent enzyme inhibitor identified in this study. Results. The binding affinity of emodin-8-glucoside, aloe-emodin 8-glucoside, pulmatin, rhodoptilometrin, and hypericin to the receptor’s ATP binding cleft was noteworthy, as the ΔGbinding values were <

−

10 kcal/mol. In addition, emodin-8-glucoside, aloe-emodin 8-glucoside, and pulmatin were found to have inhibition constant values at the picomolar concentration. According to our computer simulation results, the docked pose of emodin-8-glucoside within the active site of MAPK3 achieved a stable state after 70 ns. In other words, the root mean square deviation (RMSD) graph indicated stability within the 70–100 ns timeframe. Conclusion. Inhibition of MAPK3 by emodin-8-glucoside, aloe-emodin 8-glucoside, pulmatin, rhodoptilometrin, and hypericin may have therapeutic potential in cancer treatment.
Estrogen‐Related Receptor Gamma Gene Therapy Promotes Therapeutic Angiogenesis and Muscle Recovery in Preclinical Model of PAD
Authors: Sopariwala Danesh H. , Rios Andrea S. , Saley Addison , Kumar Ashok , Narkar Vihang A. 
Published: August 2023

Background
Peripheral arterial disease and critical limb ischemia are cardiovascular complications associated with vascular insufficiency, oxidative metabolic dysfunction, and myopathy in the limbs. Estrogen‐related receptor gamma (ERRγ) has emerged as a dual regulator of paracrine angiogenesis and oxidative metabolism through transgenic mouse studies. Here our objective was to investigate whether postischemic intramuscular targeting of ERRγ via gene therapy promotes ischemic recovery in a preclinical model of peripheral arterial disease/critical limb ischemia.

Methods and Results

Adeno‐associated virus 9 (AAV9)
Esrrg
gene delivery vector was developed and first tested via intramuscular injection in murine skeletal muscle. AAV9‐Esrrg robustly increased ERRγ protein expression, induced angiogenic and oxidative genes, and boosted capillary density and succinate dehydrogenase oxidative metabolic activity in skeletal muscles of C57Bl/6J mice. Next, hindlimb ischemia was induced via unilateral femoral vessel ligation in mice, followed by intramuscular AAV9‐Esrrg (or AAV9‐green fluorescent protein) gene delivery 24 hours after injury. ERRγ overexpression increased ischemic neoangiogenesis and markers of endothelial activation, and significantly improved ischemic revascularization measured using laser Doppler flowmetry. Moreover, ERRγ overexpression restored succinate dehydrogenase oxidative metabolic capacity in ischemic muscle, which correlated with increased mitochondrial respiratory complex protein expression. Most importantly, myofiber size to number quantification revealed that AAV9‐Esrrg restores myofibrillar size and mitigates ischemia‐induced myopathy.

Conclusions

These results demonstrate that intramuscular AAV9‐Esrrg delivery rescues ischemic pathology after hindlimb ischemia, underscoring that
Esrrg
gene therapy or pharmacological activation could be a promising strategy for the management of peripheral arterial disease/critical limb ischemia.
Personality and behavioural syndromes in wild-caught Namaqua rock mice (Micaelamys namaquensis)
Authors: Oosthuizen Tasha , Lutermann Heike 
Published: August 2023

Abstract
Rodents from the southern hemisphere are underrepresented in studies of animal personality. In the current study, we assessed personality in 22 wild-caught Namaqua rock mice (Micaelamys namaquensis), a species that is widespread throughout southern Africa. We assessed exploration, aggression and boldness scores and evaluated the effects of intrinsic (i.e., sex) and extrinsic (i.e., captive environment) factors on personality. Rock mice showed personality and behavioural plasticity. While sex alone was not an important factor in the personality of this species, the initial trial differed significantly from subsequent ones, indicative of capture stress and/or subsequent habituation. We found a behavioural syndrome between aggressiveness and exploration, as well as between aggressiveness and boldness scores. Thus, our study extends our knowledge of personality and behavioural syndrome in wild rodents and suggests a role of sex on habituation. The fitness implications of these findings for the study species merit further study in the future.
Hugo’s Moments, Maria’s Everyday Chores? Discords in the Search for Grotian Moments for Women’s Rights in International Law
Authors: Tallgren Immi 
Published: August 2023

Abstract
This chapter would have liked to invite its readers on an exciting but breath-taking journey through the historical landscapes of international law, since ‘time immemorial’ a male-centred and, until the 1990s, almost exclusively male intellectual tradition and professional practice – at least in the eyes of the currently dominating historiography. Helas, the ambition had to be downscaled into a few rapid zooms, touristic snapshots in an impressionistic mode, on seven contexts in time and space in a hasty timeline from the eighteenth century to 2021. They reflect, merely as examples, women’s status in international law in diverse political, social and legal transformations or crisis. Some are representing moments of codification or the break-through of certain interpretations of women’s rights. Others are selected for their role in enabling women’s participation in decision-making or entry to international legal positions, or because they provide an example of women’s international activism for women’s rights. All of them might have preceded, followed, or in fact themselves constituted ‘Grotian Moments’ for ‘women’s rights’ – did they, and if not, why? Should they have? If yes, which ones and how, to what effect for ‘women’?
First records of cave-dwelling pseudoscorpions of the genus Ephippiochthonius Beier, 1930 (Arachnida: Pseudoscorpiones: Chthoniidae) from the Caucasus, with description of three new species from Abkhazia and taxonomic comments on the genus
Authors: TURBANOV ILYA S. , KOLESNIKOV VASILIY B. 
Published: August 2023

Three new hypogean Ephippiochthonius species from karst caves of Abkhazia (Western Caucasus) are described, including detailed diagnoses and illustrations: Ephippiochthonius kovali sp. nov., E. vargovitshi sp. nov. and E. dbari sp. nov. These are the first cave-dwelling species of the genus described from the Caucasus. The taxonomic significance of the position of the intermediate setae ih3 and ih4 on the antiaxial side of chelal hand in the genus Ephippiochthonius is discussed. Based on this and other features, the heterogeneity of the tetrachelatus-group is demonstrated. Given the presence of seta ph3, the following new combinations are proposed for the species formerly assigned to Ephippiochthonius: Occidenchthonius kemza (Ćurčić, Lee et Makarov, 1993) comb. nov. from Pecina u Kozuvarskoj Glami Cave, Serbia and Occidenchthonius romanicus (Beier, 1935) comb. nov. from Comana, Romania (all ex Ephippiochthonius).
Groundwater Feedbacks on Climate Change in the CNRM Global Climate Model
Authors: Colin Jeanne , Decharme Bertrand , Cattiaux Julien , Saint-Martin David 
Published: August 2023

Abstract
Groundwater and climate interact in a two-way manner. Precipitation ultimately controls groundwater recharge and, conversely, groundwater may influence climate through evapotranspiration. Yet very few global climate models or Earth system models actually simulate groundwater flows. And while the expected impacts of climate change on groundwater resources are the subject of a growing concern, global-scale groundwater–climate feedbacks have received very little attention so far. Here we show that the integration of unconfined aquifers in a global climate model can regionally affect the climate change signal on temperatures and precipitation. We assess the impact of groundwater under preindustrial and 4xCO2 conditions (after climate stabilization). In both cases, we find that groundwater has a cooling and a wetting effect in certain regions of the world. In eastern Europe, both these impacts are stronger in the warmer climate (4xCO2 forcing) where the presence of groundwater reduces the frequency of summer heatwaves by 40%, compared to a 15% reduction in the preindustrial world. This work constitutes one of the very first global assessments of the potential feedbacks of groundwater on climate change. Our results support the idea that groundwater should be represented in global climate models and Earth system models, as it does indeed play an active role in the climate system.
Prospective Randomized Clinical Trial of Arthroscopic Repair Versus Debridement for Partial Subscapularis Tendon Tears More Than Half of the Entire First Facet
Authors: Jeong Jeung Yeol , Kim Su Cheol , Lee Sang Min , Yoo Jae Chul 
Published: August 2023

Background: Most outcome studies on subscapularis (SSC) tendon tears have focused on large SSC tears rather than partial SSC tendon tears. Therefore, the optimal treatment for partial SSC tendon tears more than half of the first facet of the entire SSC footprint has not yet been clearly defined. Purpose: To prospectively investigate the clinical and radiological results between the arthroscopic repair group and the debridement group in SSC partial tear (Yoo and Rhee classification, type 2B: SSC tendon tears of more than half of the entire first facet). Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A total of 65 patients with SSC tendon type 2B tears were randomized to arthroscopic debridement (n = 33) or arthroscopic repair (n = 32). Clinical evaluation of the patients was performed on the day before surgery and 6 months, 1 year, 2 years, and 5 years postoperatively using active range of motion measurements and other validated scores (pain visual analog scale scores, function visual analog scale scores, Constant score, American Shoulder and Elbow Surgeons score). In addition, SSC muscle strength was measured using instruments in the belly-press position. Magnetic resonance imaging (upper and lower SSC muscle diameters, Goutallier grades) was performed on the day before operation as well as 6 months and 2 years postoperatively. Results: There were no clinically or statistically significant differences between the arthroscopic debridement and arthroscopic repair groups with respect to active range of motion, pain visual analog scale scores, function visual analog scale scores, Constant scores, or American Shoulder and Elbow Surgeons scores. There was a statistically significant increase in SSC muscle strength in the repair group compared with the debridement group at 5 years postoperatively ( P = .013). Magnetic resonance imaging assessment was also not significantly different between the 2 groups. Conclusion: There were no differences in the patient-reported outcomes of patients with partial SSC tears treated with either arthroscopic debridement or repair, although there was an increase in SSC muscle strength associated with repair, the clinical importance of which may warrant further research. Registration: NCT03183466 (ClinicalTrials.gov identifier).
REBT for Depression in Teens
Authors: Khanolkar Swati 
Published: August 2023

REBT is an evidence-based approach that helps people manage cognitive, emotional, and behavioral disturbances in sustainable, healthy ways. It takes a holistic view of emotional disturbances, including depression. In keeping with the concept of psychological interactionism, REBT views depression as a thinking-feeling-behaving pattern and not a diagnostic label alone. Depressive thinking-feeling-behaving is a common consequence in teens in response to such adversities and can manifest in different ways. Some may want to resign to their fate and let others make these choices for them, some may want to gain more control by trying to make perfect choices, and some may want to escape the conflict by hurting themselves, overly consuming online content, binge eating junk food, and so on, and others may want to rebel and make extreme choices. Most of these ways prove to be short-term ways of coping with or managing these challenges and may be in fact harmful in the long term. REBT argues that therapy can teach teenagers to identify, practice, and internalize healthy, long-term ways of coping which they can eventually use independently across different situational contexts.
Hindfoot Arthrodeses and the Order of Joint Fixation Influence Tibiotalar Kinematics During Simulated Stance
Authors: Palma Joaquin , Kim Jaeyoung , Hoffman Jeffrey W. , Ellis Scott J. , Demetracopoulos Constantine A. , Steineman Brett D. 
Published: August 2023

Background: Although hindfoot arthrodeses relieve pain and correct deformity, they have been associated with progressive tibiotalar degeneration. The objective was to quantify changes in tibiotalar kinematics after hindfoot arthrodeses, both isolated subtalar and talonavicular, as well as double arthrodesis, and to determine if the order of joint fixation affects tibiotalar kinematics. Methods: Hindfoot arthrodeses were performed in 14 cadaveric mid-tibia specimens. Specimens randomly received isolated fixation of the subtalar or talonavicular joint first, followed by fixation of the remaining joint for the double arthrodesis. A 6-degree-of-freedom robot sequentially simulated the stance phase of level walking for intact, isolated, and double arthrodesis conditions. Tibiotalar kinematic changes were compared for the intact and arthrodesis conditions. A subsequent analysis assessed the effect of the joint fixation order on tibiotalar kinematics. Results: Isolated and double hindfoot arthrodeses increased tibiotalar plantarflexion, inversion, and internal rotation during late stance. Tibiotalar kinematics changes occurring after isolated arthrodesis remained consistent after the double arthrodesis for both the subtalar- and talonavicular-first conditions. The order of joint fixation influenced tibiotalar kinematics through some portions of stance, where the talonavicular-first double arthrodesis increased tibiotalar plantarflexion, eversion, and internal rotation compared to the subtalar-first double. Conclusion: Tibiotalar kinematics were modestly altered for all conditions, both isolated and double hindfoot arthrodeses. Changes in tibiotalar kinematics were consistent from the isolated to the double arthrodesis conditions and varied depending on which isolated hindfoot arthrodesis was performed first. Further research is needed to assess the clinical implications of the observed changes in tibiotalar kinematics, particularly as it pertains to the development of adjacent joint arthritis. Clinical Relevance: These findings may correlate with clinical research that has cited hindfoot arthrodesis as a risk factor for adjacent tibiotalar arthritis. Once either the subtalar or talonavicular joint is fused, avoiding the arthrodesis of the second joint may not necessarily protect the tibiotalar joint.
Digital divide or digital exclusion? Do allied health professionals’ assumptions drive use of telehealth?
Authors: Cook Renee , Haydon Helen M , Thomas Emma E , Ward Elizabeth C , Ross Julie-Anne , Webb Clare , Harris Michael , Hartley Carina , Burns Clare L , Vivanti Angela P , Carswell Phillip , Caffery Liam J 
Published: August 2023

Introduction Telehealth use within allied health services currently lacks structure and consistency, ultimately affecting who can, and cannot, access services. This study aimed to investigate the factors influencing allied health professionals’ (AHP) selection of consumers and appointments for telehealth. Methods This study was conducted across 16 allied health departments from four Australian hospitals. Semi-structured focus groups were conducted with 58 AHPs. Analysis was underpinned by Qualitative Description methodology with inductive coding guided by Braun and Clarke's thematic analysis approach. Results Six themes were identified that influenced AHPs’ evaluation of telehealth suitability and selection of consumers. These included the following: (1) ease, efficiency and comfort of telehealth for clinicians; (2) clear benefits of telehealth for the consumer, yet the consumers were not always given the choice; (3) consumers’ technology access and ability; (4) establishing and maintaining effective therapeutic relationships via telehealth; (5) delivering clinically appropriate and effective care via telehealth; and (6) external influences on telehealth service provision. A further theme of ‘assumption versus reality’ was noted to pervade all six themes. Discussion Clinicians remain the key decision makers for whether telehealth is offered within allied health services. Ease and efficiency of use is a major driver in AHP's willingness to use telehealth. Assumptions and pre-conceived frames-of-reference often underpin decisions to not offer telehealth and present major barriers to telehealth adoption. The development of evidence-based, decision-support frameworks that engage the consumer and clinician in determining when telehealth is used is required. Services need to actively pursue joint decision-making between the clinician and consumer about service delivery preferences.
Children of extremist parents: Insights from a specialized clinical team
Authors: Rousseau Cécile , Miconi Diana , Johnson-Lafleur Janique , Desmarais Christian , Hassan Ghayda 
Published: August 2023

Background Data on children who grow up with parents adhering to violent extremism is scant. This makes it extremely delicate to inform policies and clinical services to protect such children from potential physical and psychological harm. Objective This paper explores the predicament of children whose caretakers were referred to a specialized clinical team in Montreal (Canada) because of concerns about risks or actual involvement in violent extremism processes. Methods This paper uses a mixed methods concurrent triangulation design. Quantitative data was obtained through a file review (2016–2020). Qualitative data was collected through semi-structured interviews and a focus group with the team practitioners. Results Clinicians reported the presence of stereotypes in the health and social services network frequently representing religious extremist parents as potentially dangerous or having inappropriate parenting skills while minimizing the perception of risk for parents adhering to political extremism. Children displayed high levels of psychological distress, mainly related to family separation, parental psychopathology, and conflicts of loyalty stemming from familial or social alienation. Conclusions Training practitioners to be aware of their own personal and institutional bias may help them to understand the predicament of extremist parents’ children and implement systemic, trauma and attachment informed interventions.