bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultra-high efficiency bremsstrahlung production in the interaction of direct laser-accelerated electrons with high-Z material
Authors: Tavana P. , Bukharskii N. , Gyrdymov M. , Spillmann U. , Zähter Ş. , Cikhardt J. , Borisenko N. G. , Korneev Ph. , Jacoby J. , Spielmann C. , Andreev N. E. , Günther M. M. , Rosmej O. N. 
Published: May 2023

High performance of laser-driven sources of radiation is in focus of research aimed at the study of high energy density matter, pair production and neutron generation using kJ PW-laser systems. In this work, we present a highly efficient approach to generate an ultra-high flux, high-energy bremsstrahlung in the interaction of direct laser-accelerated (DLA) electrons with a several-millimeters-thick high-Z converter. A directed beam of direct laser-accelerated electrons with energies up to 100 MeV was produced in the interaction of a sub-ps laser pulse of moderate relativistic intensity with long-scale plasma of near-critical density obtained by irradiation of low-density polymer foam with an ns laser pulse. In the experiment, tantalum isotopes generated via photonuclear reactions with threshold energies above 40 MeV were observed. The Geant4 Monte Carlo code, with the measured electron energy and angular distribution as input parameters, was used to characterize the bremsstrahlung spectrum responsible for the registered yields of isotopes from 180Ta to 175Ta. It is shown that when the direct laser-accelerated electrons interact with a tantalum converter, the directed bremsstrahlung with an average photon energy of 18 MeV and ∼2⋅1011 photons per laser shot in the energy range of giant dipole resonance (GDR) and beyond (≥7.5 MeV) is produced. This results in an ultra-high photon flux of ∼6 × 1022 sr−1·s−1 and a record conversion efficiency of 2% of the focused laser energy into high-energy bremsstrahlung.
Persistence of auditory modulation of wind-induced escape behavior in crickets
Authors: Lu Anhua , Fukutomi Matasaburo , Shidara Hisashi , Ogawa Hiroto 
Published: May 2023

Animals, including insects, change their innate escape behavior triggered by a specific threat stimulus depending on the environmental context to survive adaptively the predators’ attack. This indicates that additional inputs from sensory organs of different modalities indicating surrounding conditions could affect the neuronal circuit responsible for the escape behavior. Field crickets, Gryllus bimaculatus, exhibit an oriented running or jumping escape in response to short air puff detected by the abdominal mechanosensory organ called cerci. Crickets also receive a high-frequency acoustic stimulus by their tympanal organs on their frontal legs, which suggests approaching bats as a predator. We have reported that the crickets modulate their wind-elicited escape running in the moving direction when they are exposed to an acoustic stimulus preceded by the air puff. However, it remains unclear how long the effects of auditory inputs indicating surrounding contexts last after the sound is terminated. In this study, we applied a short pulse (200 ms) of 15-kHz pure tone to the crickets in various intervals before the air-puff stimulus. The sound given 200 or 1000 ms before the air puff biased the wind-elicited escape running backward, like the previous studies using the longer and overlapped sound. But the sounds that started 2000 ms before and simultaneously with the air puff had little effect. In addition, the jumping probability was higher only when the delay of air puff to the sound was 1000 ms. These results suggest that the cricket could retain the auditory memory for at least one second and alter the motion choice and direction of the wind-elicited escape behavior.
A novel estimate of biological aging by multiple fitness tests is associated with risk scores for age-related diseases
Authors: Manca A. , Fiorito G. , Morrone M. , Boi A. , Mercante B. , Martinez G. , Ventura L. , Delitala A. P. , Cano A. , Catte M. G. , Solinas G. , Melis F. , Ginatempo F. , Deriu F. 
Published: May 2023

Introduction: Recent research highlights the need for a correct instrument for monitoring the individual health status, especially in the elderly. Different definitions of biological aging have been proposed, with a consistent positive association of physical activity and physical fitness with decelerated aging trajectories. The six-minute walking test is considered the current gold standard for estimating the individual fitness status in the elderly.Methods: In this study, we investigated the possibility of overcoming the main limitations of assessing fitness status based on a single measure. As a result, we developed a novel measure of fitness status based on multiple fitness tests. In 176 Sardinian individuals aged 51–80 years we collected the results of eight fitness tests to measure participants’ functional mobility, gait, aerobic condition, endurance, upper and lower limb strength, and static and dynamic balance. In addition, the participants’ state of health was estimated through validated risk scores for cardiovascular diseases, diabetes, mortality, and a comorbidity index.Results: Six measures contributing to fitness age were extracted, with TUG showing the largest contribution (beta = 2.23 SDs), followed by handgrip strength (beta = −1.98 SDs) and 6MWT distance (beta = −1.11 SDs). Based on fitness age estimates, we developed a biological aging measure using an elastic net model regression as a linear combination of the results of the fitness tests described above. Our newly developed biomarker was significantly associated with risk scores for cardiovascular events (ACC-AHA: r = 0.61; p = 0.0006; MESA: r = 0.21; p = 0.002) and mortality (Levine mortality score: r = 0.90; p = 0.0002) and outperformed the previous definition of fitness status based on the six-minute walking test in predicting an individual health status.Discussion: Our results indicate that a composite measure of biological age based on multiple fitness tests may be helpful for screening and monitoring strategies in clinical practice. However, additional studies are needed to test standardisation and to calibrate and validate the present results.
24-h movement behaviour, thermal perception, thirst, and heat management strategies of children and adults during heat alerts: a pilot study
Authors: Ravanelli Nicholas , Morris Nathan , Morrison Shawnda A. 
Published: May 2023

Background: Heat waves caused by climate change are increasingly challenging the wellbeing of individuals across the lifespan. Current efforts to understand the thermal perceptions and behaviours of people throughout the lifespan during heat waves are limited.Methods: Since June 2021, the Active Heatwave project has been recruiting households to better understand how individuals perceive, cope, and behave during heat waves. Using our novel web platform, participants were prompted to answer our Heat Alert Survey on days when a participants geolocation corresponded to a broadcasted local heat alert. Participants provided 24-h movement behaviour, thirst, thermal perception, and cooling strategies via validated questionnaires.Results: A total of 285 participants (118 children) from 60 distinct weather station locations globally participated between June and September 2021 and 2022. At least 1 heat alert (834 total) were identified from 95% (57/60) of the weather stations. Children reported spending more time performing vigorous intensity exercise compared to adults (p &lt; 0.05), but no differences in thermal sensation, thermal comfort, or thirst sensation (all p &gt; 0.31) were observed. For thirst management, 88% of respondents used water to relieve thirst, although notably, 15% of adults reported using alcohol. Regardless of age, staying indoors was the most common heat management strategy, whereas visiting cooling centres was the least.Conclusion: The present study presents a proof-of-concept combining local heat alert notifications with e-questionnaires for collecting near-real-time perceptual and behavioural data for both children and adults during heat waves. The observed patterns of behaviour suggest that present public heat-health guidelines are often ignored, children engage in fewer heat management strategies compared to adults, and these disparities highlight the need to improve public health communication and knowledge dissemination around promoting effective and accessible cooling solutions for children and adults.
Seasonal variations in carbon, nitrogen, and phosphorus of Pinus yunnanenis at different stand ages
Authors: Liang Siyi , Tan Tian , Wu Danzi , Li Chaojun , Jing Huiqing , Wu Junwen 
Published: May 2023

The seasonal variations in carbon (C), nitrogen (N), and phosphorus (P) at the organ level of Pinus yunnanenis during different season are poorly understood. In this study, the C, N, P, and their stoichiometric ratios in various organs of P. yunnanensis during the four seasons are discussed. The middle and young aged P. yunnanensis forests in central Yunnan province, China were chosen, and the contents of C, N, and P in fine roots (&lt;2 mm), stems, needles, and branches were analyzed. The results showed that the C, N, P contents and their ratios in P. yunnanensis were significantly influenced by season and organ, less affected by age. The C content of the middle-aged and young forests decreased continuously from spring to winter, whereas N and P first decreased and then increased. No significant allometric growth relationships were observed between P-C of the branches or stems in the young and middle-aged forests, whereas a significant allometric growth relationship existed for N-P of needles in the young stands, indicating that the P-C and N-P nutrient distribution patterns shows different trends in the organ level in different age stands. The pattern of P allocation between organs shows differences in stand age, with more allocation to needles in middle-aged stands and more allocation to fine roots in young stands. The N:P ratio in needles was less than 14, indicating that P. yunnanensis was mainly limited by N and increasing the application of N fertilizer would be beneficial for the productivity of this stand. The results will be helpful to nutrient management in P. yunnanensis plantation.
Dew benefits on alpine grasslands are cancelled out by combined heatwave and drought stress
Authors: Li Yafei , Eugster Werner , Riedl Andreas , Lehmann Marco M. , Aemisegger Franziska , Buchmann Nina 
Published: May 2023

Increasing frequencies of heatwaves combined with simultaneous drought stress in Europe threaten the ecosystem water and carbon budgets of alpine grasslands. Dew as an additional water source can promote ecosystem carbon assimilation. It is known that grassland ecosystems keep high evapotranspiration as long as soil water is available. However, it is rarely being investigated whether dew can mitigate the impact of such extreme climatic events on grassland ecosystem carbon and water exchange. Here we use stable isotopes in meteoric waters and leaf sugars, eddy covariance fluxes for H2O vapor and CO2, in combination with meteorological and plant physiological measurements, to investigate the combined effect of dew and heat-drought stress on plant water status and net ecosystem production (NEP) in an alpine grassland (2000 m elevation) during the June 2019 European heatwave. Before the heatwave, enhanced NEP in the early morning hours can be attributed to leaf wetting by dew. However, dew benefits on NEP were cancelled out by the heatwave, due to the minor contribution of dew in leaf water. Heat-induced reduction in NEP was intensified by the combined effect of drought stress. The recovery of NEP after the peak of the heatwave could be linked to the refilling of plant tissues during nighttime. Among-genera differences of plant water status affected by dew and heat-drought stress can be attributed to differences in their foliar dew water uptake, and their reliance on soil moisture or the impact of the atmospheric evaporative demand. Our results indicate that dew influence on alpine grassland ecosystems varies according to the environmental stress and plant physiology.
Resource availability and parasitism intensity influence the response of soybean to the parasitic plant Cuscuta australis
Authors: Yuan Yong-Ge , Gao Fang-Lei , Yu Fei-Hai , Li Jun-Min , Li Mai-He 
Published: May 2023

IntroductionParasitic plants can damage crop plants and consequently cause yield losses and thus threaten food security. Resource availability (e.g., phosphorus, water) has an important role in the response of crop plants to biotic attacks. However, how the growth of crop plants under parasitism are affected by environmental resource fluctuation is poorly understood.MethodsWe conducted a pot experiment to test the effects of the intensity of Cuscuta australis parasitism and the availability of water and phosphorus (P) on soybean shoot and root biomass.Results and discussionWe found that low-intensity parasitism caused ~6% biomass reduction, while high-intensity parasitism caused ~26% biomass reduction in soybean. Under 5–15% water holding capacity (WHC), the deleterious effect of parasitism on soybean hosts was ~60% and ~115% higher than that under 45–55% WHC and 85–95% WHC, respectively. When the P supply was 0 μM, the deleterious effect of parasitism on soybean was 67% lower than that when the P supply was 20 μM. Besides, the biomass of C. australis was highest when both the water and the P availability were lowest. Cuscuta australis caused the highest damage to soybean hosts under 5 μM P supply, 5–15% WHC, and high-intensity parasitism. Additionally, C. australis biomass was significantly and negatively related to the deleterious effect of parasitism on soybean hosts and to the total biomass of soybean hosts under high-intensity parasitism, but not under low-intensity parasitism. Although high resource availability can promote soybean growth, the two resources have different impacts on the response of hosts to parasitism. Higher P availability decreased host tolerance to parasites, while higher water availability increased host tolerance. These results indicate that crop management, specifically water and phosphorus supply, can efficiently control C. australis in soybean. To our best knowledge, this appears to be the first study to test the interactive effect of different resources on the growth and response of host plants under parasitism.
Systematic review of machine learning utilization within outpatient psychodynamic psychotherapy research
Authors: Rollmann Ivo , Gebhardt Nadja , Stahl-Toyota Sophia , Simon Joe , Sutcliffe Molly , Friederich Hans-Christoph , Nikendei Christoph 
Published: May 2023

IntroductionAlthough outpatient psychodynamic psychotherapy is effective, there has been no improvement in treatment success in recent years. One way to improve psychodynamic treatment could be the use of machine learning to design treatments tailored to the individual patient's needs. In the context of psychotherapy, machine learning refers mainly to various statistical methods, which aim to predict outcomes (e.g., drop-out) of future patients as accurately as possible. We therefore searched various literature for all studies using machine learning in outpatient psychodynamic psychotherapy research to identify current trends and objectives.MethodsFor this systematic review, we applied the Preferred Reporting Items for systematic Reviews and Meta-Analyses Guidelines.ResultsIn total, we found four studies that used machine learning in outpatient psychodynamic psychotherapy research. Three of these studies were published between 2019 and 2021.DiscussionWe conclude that machine learning has only recently made its way into outpatient psychodynamic psychotherapy research and researchers might not yet be aware of its possible uses. Therefore, we have listed a variety of perspectives on how machine learning could be used to increase treatment success of psychodynamic psychotherapies. In doing so, we hope to give new impetus to outpatient psychodynamic psychotherapy research on how to use machine learning to address previously unsolved problems.
Transcranial direct-current stimulation enhances Pavlovian tendencies during intermittent loss of control
Authors: Sedlinská Terezie , Bolte Lara , Melsæter Eirik , Mittner Matthias , Csifcsák Gábor 
Published: May 2023

IntroductionPavlovian bias is an innate motivational tendency to approach rewards and remain passive in the face of punishment. The relative reliance on Pavlovian valuation has been found to increase when the perceived control over environmental reinforcers is compromised, leading to behavior resembling learned helplessness (LH).MethodsSixty healthy young adults underwent a Go-NoGo reinforcement learning task and received anodal high-definition transcranial direct current stimulation (HD-tDCS) over the medial prefrontal/dorsal anterior cingulate cortex in our randomized, double-blind, sham- controlled study. Furthermore, we evaluated changes in cue-locked mid-frontal theta power derived from simultaneous electroencephalography (EEG). We hypothesized that active stimulation would reduce Pavlovian bias during manipulation of outcome controllability, and the effect would be accompanied by stronger mid-frontal theta activity, representing arbitration between choice strategies in favor of instrumental relative to Pavlovian valuation.ResultsWe found a progressive decrease in Pavlovian bias during and after loss of control over feedback. Active HD-tDCS counteracted this effect while not affecting the mid-frontal theta signal.DiscussionThe results were at odds with our hypotheses but also with previous findings reporting LH-like patterns during and after loss of control without brain stimulation. The discrepancy may be related to different protocols for the controllability manipulation. We argue that the subjective evaluation of task controllability is crucial in mediating the balance between Pavlovian and instrumental valuation during reinforcement learning and that the medial prefrontal/dorsal anterior cingulate cortex is a key region in this respect. These findings have implications for understanding the behavioral and neural underpinnings of LH in humans.
Using point-of-care HbA1c to facilitate the identification of diabetes and abnormal glucose regulation in primary healthcare settings
Authors: Pi Linhua , Zheng Ying , Shi Xiajie , Wang Zhen , Zhou Zhiguang 
Published: May 2023

BackgroundGlycated hemoglobin A1c (HbA1c) is a critical index for the diagnosis and glycemic control evaluation of diabetes. However, a standardized method for HbA1c measurement is unaffordable and unavailable among the Chinese population in low-resource rural settings. Point-of-care (POC) HbA1c testing is convenient and inexpensive, but its performance remains to be elucidated.ObjectiveTo investigate the value of POC HbA1c for identifying diabetes and abnormal glucose regulation (AGR) in the resource-limited Chinese population.MethodsParticipants were recruited from 6 Township Health Centers in Hunan Province. Samples for POC HbA1c, venous HbA1c, fasting plasma glucose, and 2 h-plasma glucose were obtained after physical examination. The oral glucose tolerance test was performed as the gold standard for diagnosis. The diagnostic capacities of the POC HbA1c measurement in predicting undiagnosed diabetes and AGR were evaluated.ResultsAmong 388 participants, 274 (70.6%) normoglycemic controls, 63 (16.2%) prediabetes patients, and 51 (13.1%) diabetes patients were identified with oral glucose tolerance test (OGTT). Meanwhile, among 97 participants who underwent two HbA1c detection methods simultaneously, a positive correlation was found between POC HbA1c and standardized HbA1c (r = 0.75, P &lt; 0.001). No notable systematic difference was observed from the Bland-Altman Plots. The POC HbA1c cutoff values were 5.95 and 5.25%, which efficiently identified diabetes (AUC 0.92) and AGR (AUC 0.89), respectively.ConclusionsThe alternative POC HbA1c test efficiently discriminated AGR and diabetes from normoglycemia, especially among the Chinese population in primary healthcare settings.
Metagenomic next-generation sequencing confirms the diagnosis of Legionella pneumonia with rhabdomyolysis and acute kidney injury in a limited resource area: a case report and review
Authors: Du Rao , Feng Yinhe , Wang Yubin , Huang Jifeng , Tao Yuhan , Mao Hui 
Published: May 2023

BackgroundLegionella pneumonia, rhabdomyolysis, and acute kidney injury are called the Legionella triad, which is rare and associated with a poor outcome and even death. Early diagnosis and timely treatment are essential for these patients.Case presentationA 63-year-old man with cough, fever, and fatigue was initially misdiagnosed with common bacterial infection and given beta-lactam monotherapy but failed to respond to it. Conventional methods, including the first Legionella antibody test, sputum smear, and culture of sputum, blood, and bronchoalveolar lavage fluid (BALF) were negative. He was ultimately diagnosed with a severe infection of Legionella pneumophila by metagenomics next-generation sequencing (mNGS). This patient, who had multisystem involvement and manifested with the rare triad of Legionella pneumonia, rhabdomyolysis, and acute kidney injury, finally improved after combined treatment with moxifloxacin, continuous renal replacement therapy, and liver protection therapy.ConclusionOur results showed the necessity of early diagnosis of pathogens in severe patients, especially in Legionnaires' disease, who manifested with the triad of Legionella pneumonia, rhabdomyolysis, and acute kidney injury. mNGS may be a useful tool for Legionnaires' disease in limited resource areas where urine antigen tests are not available.
COVID-19 vaccination dynamics in the US: coverage velocity and carrying capacity based on socio-demographic vulnerability indices in California's pediatric population
Authors: Bruckhaus Alexander A. , Khan Azrin , Pickering Trevor A. , Abedi Aidin , Salehi Sana , Duncan Dominique 
Published: May 2023

IntroductionCOVID-19 vaccine inequities have been widespread across California, the United States, and globally. As COVID-19 vaccine inequities have not been fully understood in the youth population, it is vital to determine possible factors that drive inequities to enable actionable change that promotes vaccine equity among vulnerable minor populations.MethodsThe present study used the social vulnerability index (SVI) and daily vaccination numbers within the age groups of 12–17, 5–11, and under 5 years old across all 58 California counties to model the growth velocity and the anticipated maximum proportion of population vaccinated.ResultsOverall, highly vulnerable counties, when compared to low and moderately vulnerable counties, experienced a lower vaccination rate in the 12–17 and 5–11 year-old age groups. For age groups 5–11 and under 5 years old, highly vulnerable counties are expected to achieve a lower overall total proportion of residents vaccinated. In highly vulnerable counties in terms of socioeconomic status and household composition and disability, the 12–17 and 5–11 year-old age groups experienced lower vaccination rates. Additionally, in the 12–17 age group, high vulnerability counties are expected to achieve a higher proportion of residents vaccinated compared to less vulnerable counterparts.DiscussionThese findings elucidate shortcomings in vaccine uptake in certain pediatric populations across California and may help guide health policies and future allocation of vaccines, with special emphasis placed on vulnerable populations, especially with respect to socioeconomic status and household composition and disability.