bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of growth differentiation factor-15 in polytransfused children with β-thalassemia
Authors: Meena Swati , Sharma Kusha , Sharma Sunita , Chandra Jagdish 
Published: January 2023

Background:
Ineffective erythropoiesis is a predominant feature in β-thalassemia major (β-TM), causing marked erythroid expansion leading to highly raised levels of growth differentiation factor-15 (GDF-15), which, in turn, suppresses hepcidin production in liver resulting in increased iron absorption from gut. We aim to study the serum GDF-15 in polytransfused β-TM patients and its correlation with serum ferritin and serum hepcidin.

Method:
Thirty-nine polytransfused β-TM children aged between 5 and 17 years and 33 age- and gender-matched healthy controls were enrolled in the study. Complete blood count, serum GDF-15, serum ferritin, and serum hepcidin were performed.

Results:
The mean serum GDF-15, serum hepcidin, and serum ferritin levels were 638.65 ± 306.96 pg/ml, 108.21 ± 191.30 ng/ml, and 2274.60 ± 1216.08 ng/ml, respectively, which were significantly higher than control group (P < 0.001, P = 0.003, P < 0.001, respectively). There was significant positive correlation of GDF-15 with blood transfusions (r = 0.415, P = 0.009), positive correlation with serum ferritin (r = 0.653, P = 0), and significant negative correlation with serum hepcidin (r = −0.508, P = 0.001).

Conclusion:
The findings of the present study suggest that GDF-15 is an important regulator of hepcidin in β-TM patients. GDF-15 and serum hepcidin together can be used to monitor iron overload and its related complications in such patients.
Immunohistochemical appraisal of epithelial mesenchymal transition type III in gall bladder cancer
Authors: Yadav Kamini , Agarwal Preeti , Kumar Madhu , Gupta Sameer , Mishra Medha , Maurya Malti Kumari , Qayoom Sumaira , Goel Madhu Mati 
Published: January 2023

Background:
Epithelial-mesenchymal transition (EMT) is the heart of invasion. EMT associated with cancer progression and metastasis is known as type III EMT. Beta-catenin, E-cadherin, and MMP9 markers of EMT are routinely employed for diagnostic purposes.

Aims:
We employed these markers to study EMT by immunohistochemistry (IHC) in gall bladder cancer (GBC) with respect to depth of tumor invasion, clinical outcome, and disease-free survival.

Settings and Design:
This was a prospective case-control study.

Material and Methods:
Seventy gall bladders were included (50 GBC and 20 CC). After detailed histology, immunoexpression was studied in terms of percentage and strength of expression.

Statistics Analysis Used:
Expression was compared between CC and GBC by Student t test and analysis of variance. Kaplan–Meier was used for survival analysis, and the extent of agreement (“Kappa”) was calculated.

Results and Conclusions:
The age of incidence of GBC was 49.40 (+11.6) years with female predominance (F:M = 4:1). In 88% (44/50) of GBC, the fundus was involved. Moderately differentiated adenocarcinoma was most frequent [54%; 27/50]. Significant downregulation of E-cadherin (P = 0.022) and beta-catenin (P < 0.001) and upregulation in MMP9 (P < 0.001) were seen in GBC with respect to CC with significant association among them. MMP9 expression was significantly associated with higher tumor stage but with chemotherapeutic response. Our results display that epithelial-mesenchymal transition type III plays a role in GBC invasion. MMP9 overexpression and loss of membranous beta-catenin may be considered a marker for poor clinical outcomes and advanced disease.
Survival and prognostic factors among hospitalized pancreatic cancer patients in Northwestern Iran
Authors: Vahedi Leila , Asvadi Kermani Touraj , Asghari-Jafarabadi Mohammad , Asghari Elham , Mohammadi Seyedeh Momeneh , Khameneh Amin 
Published: January 2023

Background:
Pancreatic cancer (PC) is associated with a poor prognosis, with various modifiable risk factors affecting the survival of patients. Our aim was to evaluate the survival rate and the prognostic factors influencing survival in PC patients in northwestern Iran.

Materials and Methods:
All the PC patients admitted to the Imam Reza Hospital of Tabriz, Iran, from 2016 to 2020, were enrolled in this study. The survival rate and time were calculated, and the risk factors related to survival were evaluated by Cox regressions. The data were analyzed using the Cox proportional hazards model using STATA software.

Results:
Of 110 patients, 12-, 24-, 36-, and 48-month survival rates were 29.1%, 19.8%, 14.1%, and 8.5%, respectively, with the median survival time of seven months. The mean age was 65.5 years. The results showed that a higher age (hazard ratio [HR] [95% confidence interval (CI)] = 2.04 [1.20–3.46]), lower education (1.72 [1.03–2.89]), delayed diagnosis (1.03 [1.02–1.05]), hypertension (1.53 [1.01–2.31]), concomitant heart disorders (2.67 [1.50–4.74]), COPD (4.23 [1.01–17.69]), consanguineous marriage (1.59 [1.01–2.50]), and the presence of icterus complications (adjusted HR = 3.64 [1.56–8.49]) were directly associated with a worse survival. On the contrary, radiotherapy (0.10 [0.01–0.85]), chemotherapy (0.57 [0.36–0.89]), and surgical therapy (AHR = 0.48 [0.23–0.99]) were directly related to a good prognosis.

Conclusion:
Surgery, chemotherapy, and radiotherapy were the best predictors of survival in PC patients. Moreover, it seems that resolving jaundice can improve survival in these patients. It seems that increasing social awareness, treating underlying diseases, and employing an appropriate therapeutic method may promise a better outlook, improve the survival rate of patients, and reduce PC risk.
Effectiveness of dynamic strength-endurance training of the neck and scapular muscles in reducing pain and improving function in nonspecific neck pain
Authors: Priya S. , Haripriya S. , Dhungana Milan 
Published: January 2023

BACKGROUND:
Nonspecific neck pain is a common musculoskeletal disorder causing disability among the general population. Specific dynamic strength-endurance exercises may help maintain improved posture, which in turn can lessen or eliminate recurrent flare-ups of pain. The effect of exercise on patients with chronic nonspecific neck pain has been investigated in several studies. The efficacy is, however, questionable.

AIM:
The aim of the study is to find the effectiveness of dynamic strength-endurance training in reducing pain and improving function in nonspecific neck pain.

DESIGN:
This study was a pre- and postintervention design.

SETTING:
This study was conducted in tertiary care hospital in Mangaluru.

MATERIALS AND METHODS:
In this pre- and postexperimental study, dynamic strength-endurance training for cervical and scapular muscles was given to 24 adults fulfilling inclusion criteria for 4 weeks. The Neck Disability Index (NDI) was used for pain and disability assessment, and the Neck Bournemouth Questionnaire (NBQ) and the Northwick Park Neck Pain Questionnaire (NPNQ) were used for pain assessment.

RESULTS:
There was a significant reduction in NDI, NBQ, and NPNQ scores exceeding minimal clinically important difference (NDI >7.5 points, NBQ >5.5 points, and NPNQ >7.6 points) after 4 weeks of strength-endurance training of cervical and scapular muscles. There was significant improvement in hold time. Statistically, a significant difference was observed in pre- and posttreatment effect comparison of all outcome measures (P > 0.01).

CONCLUSION:
A dynamic strength-endurance training program is effective in reducing pain and disability in a patient with nonspecific neck pain.
The Value of Family and Friendship Ties and Their Effect on Providing Funding for Millennial Entrepreneurs
Authors: Yoga Ika , Ambarwati Retnoning 
Published: January 2023

Providing financing for entrepreneurs becomes an interesting topic to discuss in relation to the financial literature, especially in the financial literature of small and medium enterprises. The purpose of this study is to investigate the value of family and friendship ties in financing millennial entrepreneurs. This study will focus on analyzing the level of support and financial assistance millennial entrepreneurs receive from their family and friends. In addition, this study will examine the factors that influence family and friends' decision to finance millennial entrepreneurial ventures. The research will be conducted through surveys and in-depth interviews with millennial entrepreneurs and their funder family and friends. The findings of this research will provide valuable insights into the importance of human relationships in the entrepreneurial ecosystem and inform future support programs for young entrepreneurs. The data used in this study are the results of a questionnaire given to small and medium business actors in the ex-residency area of Surakarta. The method used in this research is the method of SEM-PLS. The finding of multiple regression analysis techniques reveals that e value of family ties and the value of friendship had a significant influence on providing funding for entrepreneurs. These findings suggest that young entrepreneurs should pay attention to and be able to build strong relationships with their family and friends in the hope that these relationships can play an important role in securing funding for their business. The next research is expected to be able to study more deeply about its effect on the surplus value obtained compared to unrelated third party financing
FAKTOR – FAKTOR PENYEBAB RENDAHNYA AKSEPTOR ALAT KONTRASEPSI DALAM RAHIM DI BPM SUCI PAIMIN KECAMATAN BENDOSARI KABUPATEN SUKOHARJO
Authors: Utomo Endrat Kartiko , Hidayati Wahyu , Mursudarinah M 
Published: January 2023

Introduction: The rationale for the birth of family planning in Indonesia is the population problem. The important aspects of population are the size of the population, the number of population growth, the number of deaths, and the number of population movements. Based on data from the Central Java Province BKKBN, the number of IUD KB participants in 2014 was 472,217.
Objective: to describe the factors causing the low acceptors of intrauterine devices at BPM Suci Paimin, Bendosari District, Sukoharjo Regency.
Method: This research method uses a single variable with a non-probability sampling technique, namely accidental sampling. Family planning acceptors at BPM Suci Paimin, Toriyo Village, Bendosari District, Sukoharjo Regency, were 57 respondents. The measuring instrument used is a questionnaire.
Results: This study found that the factors that caused the low acceptors of intrauterine devices were elementary education at 42.1%, environmental factors did not support it at 86.0%, and husband's support 100% husband did not support or approve.
Conclusion: The factors causing the low acceptors of intrauterine devices, the factor at BPM Suci Paimin, Bendosari District, Sukoharjo Regency, is the husband's most dominant support factor because 100% of husbands do not support or approve.
TINJAUAN PELAKSANAAN PENGELOLAAN DOKUMEN REKAM MEDIS DI BAGIAN FILING DI PUSKESMAS WONOSARI 1
Authors: Arini Liss Dyah Dewi , Arthama Ananda Meyrika , Ifalahma Darah 
Published: January 2023

Introduction: The implementation of the management of medical record documents at the Wonosari 1 Health Center there are still obstacles including in the medical record document storage section there is still a misfile because the medical record document after being used is not directly stored on the storage rack and there is still a buildup of medical record documents outside the medical record document storage rack and not yet there is a tracer.
Objectives: The purpose of this study was to determine the implementation of medical record document management in the filing section at the Wonosari 1 Health Center.Methods: This research is a descriptive study with a cross sectional approach. The subjects of this research are filing officers and registration officers. The objects of this research are medical record documents, Standard Operating Procedures (SPO) and filing facilities. Result: The results showed that the implementation of storage and alignment of medical record documents was in accordance with Standard Operating Procedures (SPO), namely family folder storage and centralization, namely outpatient medical record documents, inpatient care, one family emergency room stored in one folder and the alignment based on Straight Numerical filing (SNF).Conclusion: the implementation of storage and alignment of medical record documents still found misfiles. this is because after used documents are not directly stored on the storage rack and the tracer aids are not used at the time of retrieval and return of medical record documents.
The creation performance of Tang Ong Song Pok
Authors: Narksen Supat 
Published: January 2023

The study of the creation of performance, costume and accessories has the objective to create the performance conveying Nora’s dressing of Nora Yai’s dressing style (Nora is called for the Classical Thai Tune of Southern of Thailand), posture, style of dance and patterns of dressing from documents, observations, interviews from the Nora’s artists as well as experiences of creators being analyzed into the knowledge based on the concept of creative theory in 7 steps of Emeritus Prof. Dr. Surapon Wirunrak and being presented in the form of creative dance art adapted from traditional dance with the creative dance moves created from 20 prototypical dance moves of Nora, 6 dance moves imitating from the nature and 23 new creative dance moves. The pattern of performance is divided into 3 parts as follows;
The first part is the Mantra character. 3 male performers gradually release in the rhythm of the drum and spin one round and then dance to Pleng Patcha with the first performer writing the character “นะ” (na), “มะ” (ma). The second performer writes the character “อะ” (Ah) and the third performer writes “อุ” (au). After that they dance to summon the holy thing.
The second part is the dressing grace. The performers make the dance moves with singing Thai octameter poem of Nora in the melody of drum known as Tub and in the melody of hexameter poem transmitting the importance and costume of Nora’s dressing.
The third part is the delicate worship to teachers. The performers make the dance moves in the song of worship teacher with 3 dance moves representing the delicacy, stability and expertise and dance of Pleng Krai throughout Pleng Ched to get back the stage.
The creation, the dressing style of the traditional Nora costume as Nora’s dressing, the singing in a southern accent and the traditional and recreated melody of southern folk music.
Walailak Abode of Culture journal and advancement toward international databases
Authors: Waiyawek Pennapa 
Published: January 2023

Walailak Abode of Culture journal has been a journal in art and culture for more than 20 years with determination to disseminate news and knowledge of art and culture and serve as an open forum for exchange of academic knowledge of art and culture. Walailak Abode of Culture is a journal of Walailak University, nurtured and driven forward under Walailak University 20-year strategic plan transforming the university into “prestigious research university of Thailand” and “World class University”.
Walailak Abode of Culture Journal needs to devise a development plan to promote the journal’s standard to measure up to international databases’ standard. This article presents a promotion and development plan of Walailak Abode of Culture Journal outlined based on the analysis of the journal’s various topics: workflow of CJWU, analysis of CJWU using SWOT Analysis, Setting OKR objective and key results of the journal and strategic plan of the journal operation. The insights extracted will be used as strategies and guidelines on making the journal achieve the goals by leaps and bounds on the basis of virtue and responsibility, and paving the way for international databases as planned between 2023 and 2027.
Konversi Agama dan Fenomena Hijrah Milenial (Aksi Konsumsi Generasi Milenial Dalam Trend Fashion Hijab)
Authors: Mega Purnamawati Agustin 
Published: January 2023

Fenomena hijrah saat ini sudah menjangkiti berbagai kalangan masyarakat, artis, maupun mahasiswa. Fenomena ini dapat dijelaskan dengan konsep konversi agama dengan menekankan peran agama dalam perubahan yang dialami seseorang atau bisa juga perubahan keagamaan yang dialami seseorang akibat dari berbagai faktor. Dikalangan masyarakat, artis ataupun mahasiswa (generasi milenial) saat ini mereka tidak mengaitkan peran perubahan dalam berhijab dalam agama dengan baik, mereka hanya mengikuti trend fashion yang saat ini sedang membumi. Perilaku yang selalu mengikuti trend fashion, cenderung menimbulkan pola konsumsi yang berlebihan.
Berdasarkan hasil penelitian di UIN Sayyid Ali Rahmatullah TULUNGAGUNG bahwa jawaban satu dengan yang lain adalah hampir serupa, dimana mereka membeli hijab demi tampil trendy, membeli hijab berdasrkan pertimbangan harga bukan berdasar atas dasar manfaat, membeli hijab karena kebiasaan setiap bulan,membei hijab karena modis dan menarik, membeli hijab untuk koleksi, membeli hijab dengan menghutang, Tentu hal tersebut tidak sesuai atau bertentangan dengan Syariah Islam, seharusnya generasi milenial menerapkan prinsip kesederhanaan dalam berhijrah, dimana pengeluaran harus dikontrol, dan berhijrah seharusnya dimulai dari hati, bukan hanya berhijrah dengan membeli hijab sebanyak-banyaknya karena mengikuti trend fashion, karena dalam prinsip moralitas sudah ditegaskan bahwa, seseorang konsumen muslim akan selalu terikat hubungannya dengan sang pemberi nikmat, yaitu Allah SWT.
Kata Kunci: Konversi Agama, Fenomena Hijrah, Milenial
STUDENT LEARNING ACTIVITY RELATED TO CLASSROOM MANAGEMENT: HOW TEACHER ROLE?
Authors: Fidrayani  , Mawadah Sakinah 
Published: January 2023

Penelitian ini bertujuan untuk mengetahui adanya hubungan antara pengelolaan kelas dengan keaktifan belajar peserta didik kelas IV di MI El-Syifa Ciganjur. Jenis penelitian ini ialah deskriptif korelasional yang bersifat ex post facto (pengukuran sesudah kejadian). Besar populasi dalam penelitian ini yaitu seluruh peserta didik kelas IV MI El-Syifa Ciganjur sebanyak 100 peserta didik dengan sampel penelitian menggunakan sampel jenuh. Teknik pengumpulan data dalam penelitian ini menggunakan angket pada pengelolaan kelas dan keaktifan belajar peserta didik. Teknik analisis data yang digunakan ialah teknik korelasi product moment, untuk mencari adanya hubungan dan koefisien determinasi serta mengetahui kontribusi variabel pengelolaan kelas terhadap variabel keaktifan belajar peserta didik. Hasil penelitian yang telah didapat menunjukkan terdapat hubungan yang positif signifikan antara pengelolaan kelas dengan keaktifan belajar peserta didik kelas IV di MI El-Syifa Ciganjur dengan nilai korelasi (rxy) sebesar 0,609 dengan tingkat hubungan berada pada kategori kuat. Hasil koefisien determinasi pada penelitian ini sebesar 0,37 yang berarti kontribusi variabel pengelolaan kelas sebesar 37% terhadap keaktifan belajar peserta didik.
Isotopic measurements in water vapor, precipitation, and seawater during EUREC4A
Authors: Bailey Adriana , Aemisegger Franziska , Villiger Leonie , Los Sebastian A. , Reverdin Gilles , Quiñones Meléndez Estefanía , Acquistapace Claudia , Baranowski Dariusz B. , Böck Tobias , Bony Sandrine , Bordsdorff Tobias , Coffman Derek , de Szoeke Simon P. , Diekmann Christopher J. , Dütsch Marina , Ertl Benjamin , Galewsky Joseph , Henze Dean , Makuch Przemyslaw , Noone David , Quinn Patricia K. , Rösch Michael , Schneider Andreas , Schneider Matthias , Speich Sabrina , Stevens Bjorn , Thompson Elizabeth J. 
Published: January 2023

Abstract. In early 2020, an international team set out to investigate
trade-wind cumulus clouds and their coupling to the large-scale circulation
through the field campaign EUREC4A: ElUcidating the RolE of
Clouds-Circulation Coupling in ClimAte. Focused on the western tropical
Atlantic near Barbados, EUREC4A deployed a number of innovative
observational strategies, including a large network of water isotopic
measurements collectively known as EUREC4A-iso, to study the tropical
shallow convective environment. The goal of the isotopic measurements was to
elucidate processes that regulate the hydroclimate state – for example, by
identifying moisture sources, quantifying mixing between atmospheric layers,
characterizing the microphysics that influence the formation and persistence
of clouds and precipitation, and providing an extra constraint in the
evaluation of numerical simulations. During the field experiment,
researchers deployed seven water vapor isotopic analyzers on two aircraft,
on three ships, and at the Barbados Cloud Observatory (BCO). Precipitation
was collected for isotopic analysis at the BCO and from aboard four ships.
In addition, three ships collected seawater for isotopic analysis. All told,
the in situ data span the period 5 January–22 February 2020 and
cover the approximate area 6 to 16∘ N and 50 to 60∘ W,
with water vapor isotope ratios measured from a few meters above sea level
to the mid-free troposphere and seawater samples spanning the ocean surface
to several kilometers depth. This paper describes the full EUREC4A isotopic in situ data collection
– providing extensive information about sampling strategies and data
uncertainties – and also guides readers to complementary remotely sensed
water vapor isotope ratios. All field data have been made publicly available
even if they are affected by known biases, as is the case for high-altitude
aircraft measurements, one of the two BCO ground-based water vapor time
series, and select rain and seawater samples from the ships. Publication of
these data reflects a desire to promote dialogue around improving water
isotope measurement strategies for the future. The remaining, high-quality
data create unprecedented opportunities to close water isotopic budgets and
evaluate water fluxes and their influence on cloudiness in the trade-wind
environment. The full list of dataset DOIs and notes on data quality flags
are provided in Table 3 of Sect. 5 (“Data availability”).