bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Analysis of Nebulizers in Clinical use for Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)
Authors: Göhler Daniel , Oelschlägel Kathrin , Ouaissi Mehdi , Giger-Pabst Urs 
Published: March 2023

AbstractObjectiveTechnical ex-vivo comparison of commercial nebulizer nozzles used for Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC).MethodsThe performance of four different commercial nebulizer nozzles (Nebulizer; HurriChem™; MCR-4 TOPOL®; QuattroJet) was analysed by comparing: i) technical design and principle of operation, ii) operational pressure as function of the liquid flow rate, iii) droplet size distribution via laser diffraction spectrometry, iv) spray cone angle, spray cone form, and horizontal drug deposition through image-metric analyses, and v) chemical resistance via exposing to a cytostatic solution and metallurgic composition by means of spark optical emission spectral analysis.ResultsThe Nebulizer exhibits a nearly identical technical design, implying a comparable performance (e.g., mass median droplet size of 29 μm) as the original PIPAC nozzles (MIP/ CapnoPen). The other three nozzles demonstrate varying degrees of performance deviation from the original PIPAC nozzles. The HurriChem™ shares a similar design and principle of operation as the Nebulizer, but produces a finer aerosol with a particle size of 22 μm. The operating principles of MCR-4 TOPOL®and QuattroJet significantly differ from that of the original PIPAC nozzle technology. The MCR-4 TOPOL®nebulizer has a hollow spray cone that leads to the production of significantly larger aerosol droplets (50 μm) compared to the original PIPAC nozzles. The QuattroJet generates an aerosol droplet (22 μm) similar in size to the HurriChem™ and exhibits improved spatial drug distribution.ConclusionWhile the introduction of new PIPAC nozzles is a welcome development, differences in performance and efficacy were noted. Therefore, it is recommended that PIPAC nozzles that deviate from the current standard undergo bioequivalence testing and be implemented in accordance with the IDEAL-D framework prior to routine clinical use.
Early EEG biomarkers of perinatal arterial ischemic stroke:a case series
Authors: Fang Xiu-Ying , Wu Qiong , Wang Ying-Jie , Mao Jian 
Published: March 2023

AbstractBackgroundContinuous electroencephalogram (EEG) monitoring after seizures may provide an early clue to the diagnosis of perinatal arterial ischemic stroke (PAIS). We aimed to explore EEG biomarkers and seizure patterns of PAIS within 7 days.MethodsData of children with PAIS were retrospectively analyzed. Using multi-channel video electroencephalogram (vEEG) and amplitude-integrated electroencephalogram (aEEG), the patients were divided into three groups according to the monitoring start time after symptom onset: ≤48 h, 48–72 h, and 4–7 days. The characteristics of EEG activity and the law of seizures were compared across groups. Together with magnetic resonance imaging (MRI), the spatial correspondence between brain electrical activity and injury site was determined.ResultsOf 21 children studied, 19 (90.47%) developed disease within 48 h of delivery. Abnormal sleep–wake cycle, abnormal fast-wave activity, abnormal wave activity, hemispheric asymmetry, electrographic seizures (ESz), and electroclinical seizures (ECSz) were more common in the ≤48 h group and 48–72 h group. Differences among all groups were statistically significant (P<0.01). The most common abnormal wave activity was sharp wave or freak wave, consistent with the MRI-confirmed injury site. ESz and ECSz were detected in 12 cases (92.31%) in the ≤48 h group and two cases (15.38%) in the 48–72 h group, 66.67% were clonic, and 91.67% were frequent seizures. ESz or ECSz were not detected in the 4–7-day group. The starting point of ESz or ECSz was consistent with the area of the lesion shown by MRI.ConclusionsBi-hemispheric diffuse abnormal fast wave activity, sharp wave or freak wave activity in the local brain region, and ESz or ECSz initiated in the same brain region are EEG biomarkers indicating PAIS. The duration of ESz or ECSz triggered by PAIS was less than 72 h.
Functional Magnetic Resonance Imaging of the amygdala and subregions at 3 Tesla: A scoping review
Authors: Foster Sheryl L. , Breukelaar Isabella A. , Ekanayake Kanchana , Lewis Sarah , Korgaonkar Mayuresh S. 
Published: March 2023

AbstractThe amygdalae are a pair of small brain structures, each of which is composed of three main subregions and whose function is implicated in neuropsychiatric conditions. Functional Magnetic Resonance Imaging (fMRI) has been utilised extensively in investigation of amygdala activation and functional connectivity with most clinical research sites now utilising 3 Tesla (3T) MR systems. However, accurate imaging and analysis remains challenging not just due to the small size of the amygdala, but also its location deep in the temporal lobe. Selection of imaging parameters can significantly impact data quality with implications for the accuracy of study results and validity of conclusions. Wide variation exists in acquisition protocols with spatial resolution of some protocols suboptimal for accurate assessment of the amygdala as a whole, and for measuring activation and functional connectivity of the three main subregions, each of which contains multiple nuclei with specialised roles. The primary objective of this scoping review is to provide a comprehensive overview of 3T fMRI protocols in use to image the activation and functional connectivity of the amygdala with particular reference to spatial resolution. The secondary objective is to provide context for a discussion culminating in recommendations for a standardised protocol for imaging activation of the amygdala and its subregions. As the advantages of big data and protocol harmonisation in imaging become more apparent so, too, do the disadvantages of data heterogeneity.
Toxic or not toxic? Interlaboratory comparison reveals almost fifty-fifty chance in the cytotoxicity assessment (ISO 10993-5) of an identical medical device
Authors: Gruber Sarah , Nickel Angela 
Published: March 2023

AbstractBackgroundMedical device manufacturers are obliged to prove the biocompatibility of their products when they come into contact with the human body. The requirements for the biological evaluation of medical devices are specified by the international standard series ISO 10993. Part five of this series describes the performance ofin vitrocytotoxicity tests. This test evaluates the effects of medical device use on cell health. The existence of the specific standard suggests that the tests will produce reliable and comparable results. However, the ISO 10993-5 offers wide latitude in the test specifications. In the past, we noticed inconsistencies of the results from different laboratories.ObjectiveTo determine if the specifications of the standard ISO 10993-5 are sufficient for assessing the comparability of test results and, if not, identify potential influencing factors.MethodsAn interlaboratory comparison was conducted for thein vitrocytotoxicity test according to ISO 10993-5. Fifty-two international laboratories evaluated the cytotoxicity for two unknown samples. One was polyethylene (PE) tubing, which is expected to be non-cytotoxic and the other was polyvinyl chloride (PVC) tubing, for which a cytotoxic potential was presumed. All laboratories were asked to perform an elution test with predefined extraction specifications. The other test parameters were freely chosen by the laboratories according to the guidelines set by the standard.ResultsTo our surprise only 58 percent of the participating laboratories identified the cytotoxic potential of both materials as expected. Particularly for PVC a considerable variation of the results between the laboratories was observed (mean = 43 ± 30 (SD), min = 0, max = 100). We showed that ten percent serum supplementation to the extraction medium, as well as longer incubation of the cells with the extract, greatly increased the test sensitivity for PVC.ConclusionThe results clearly show that the specifications set by the ISO 10993-5 are not sufficient to obtain comparable results for an identical medical device. To set requirements that ensure reliable cytotoxicity assessments, further research will be necessary to identify the best test conditions for specific materials and/or devices and the standard needs to be revised accordingly.
Why do online reviewers seek anonymity? Empirical evidence on the effects of prior anonymous reviews and focal reviews
Authors: Zhang Zhiyun , Zhang Ziqiong , Zhang Zili 
Published: March 2023

PurposeOnline reviewers' identity information is an essential cue by which consumers judge reviews on ecommerce platforms. However, few studies have explored how prior anonymous reviews and focal reviews affect reviewers' preference for anonymity. The purpose of this paper is to investigate why reviewers seek anonymity in terms of prior anonymous reviews and focal reviews.Design/methodology/approachBased on restaurant reviews collected from meituan.com, one of the largest group-buying ecommerce platforms in China, this study employed logistic regression to examine how prior anonymous reviews and focal reviews are associated with reviewers' preference for anonymity.FindingsResults show that the volume and sequence of prior anonymous review are positively associated with the likelihood of reviewers' preference for anonymity, whereas focal review valence is negatively correlated with this preference. Focal review length is positively correlated with reviewers' preference for anonymity but negatively moderates the roles of review valence and prior anonymous reviews on this preference.Originality/valueThis study expands the information disclosure literature by exploring determinants of user identity disclosure from a reviewer perspective. This research also offers a methodological contribution by employing a more accurate measure to calculate reviewers' preference for anonymity, enhancing the empirical results. Lastly, this work supplements the online review literature on how prior anonymous reviews and focal reviews are associated with reviewers' identity disclosure.
Relationship between abusive supervision and workers' well-being in construction projects: effects of guanxi closeness and trust in managers
Authors: Ju Lei , Ji Yun Peng , Wu Chunlin , Ning Xin , He Yang 
Published: March 2023

PurposeThe high-pressure nature of the construction industry, along with the COVID-19 pandemic, triggered abusive supervision (i.e. workplace bullying and incivility behaviour) that has diminished workers' well-being. However, despite the growing prevalence in practice and increasing concern in academia, abusive supervision remains largely unexplored by construction management scholars. This study aims to fill the gap in the current literature by analysing the effects of abusive supervision on construction workers' well-being, the mediating role of guanxi closeness and the moderating role of trust in the manager.Design/methodology/approachA questionnaire survey was completed by 258 Chinese construction workers. The data underwent mediation and moderation analyses using PROCESS macro 3.5 for SPSS.FindingsThe results revealed that managers' abusive supervision reduced construction workers' well-being at work and in life. Guanxi closeness between manager and workers mediated the relationship between managers' abusive supervision and construction workers' well-being. Additionally, trust in managers moderated the mediating effect of guanxi closeness. This study further revealed that the emotional connection between construction managers and workers, such as expressive guanxi closeness and affective-based trust, is important in handling the impact of abusive supervision on the workers.Practical implicationsThe findings of this study provide support for recent calls to address negative manager behaviours such as abusive supervision in construction management. They aid the development of a more comprehensive internal mechanism that considers the influence of guanxi closeness on the outcomes of abusive supervision by managers at construction sites. Additionally, interventions that develop trust in managers may be particularly effective in alleviating the tension of abusive supervision. More attention should be paid to managers' emotional connections in daily construction project management.Originality/valueRather than concentrate on positive leadership, this study shifts the focus to negative leadership in construction project management by identifying abusive supervision as a negative primary antecedent of workers' well-being. While prior research has highlighted how negative manager behaviours affect workers' well-being from the conservation of resources theory (COR) perspective, this study is the first, to the authors’ knowledge, to adopt a social exchange theory perspective by introducing guanxi closeness as a mediator. It contributes to a greater understanding of how trust in the manager alleviates the negative effect of the person's abusive supervision on construction workers.
Mental and general health at the edges of owner occupation
Authors: Truong N.T. Khuong , Smith Susan J. , Wood Gavin , Clark William A.V. , Lisowski William , Ong ViforJ Rachel 
Published: March 2023

Purpose
The purpose of this paper is to consider one test of a well-functioning housing system – its impact on wellbeing. Exploring one indicator of this, this study aims to track changes in mental and general health across a mix of tenure transitions and financial transactions in three jurisdictions: Australia, the UK and the USA.

Design/methodology/approach
Using matched variables from three national panel surveys (Household, Income and Labour Dynamics in Australia, British Household Panel Survey/Understanding Society and Panel Study of Income Dynamics) over 17 years (2000–2017) to capture the sweep of the most recent housing cycle, this study adopts a difference-in-difference random-effects model specification to estimate the mental and general health effects of tenure change and borrowing behaviours.

Findings
There is an enduring health premium associated with unmortgaged owner-occupation. Mortgage debt detracts from this, as does the prospect of dropping out of ownership and into renting. A previously observed post-exit recovery in mental health – a debt-relief effect – is not present in the longer run. In fact, in some circumstances, both mental and general health deficits are amplified, even among those who eventually regain homeownership. Though there are cross-country differences, the similarities across these financialised housing systems are more striking.

Practical implications
The well-being premium traditionally associated with owner occupation is under threat at the edges of the sector in all three jurisdictions. In this, there is cross-national convergence. There may therefore be scope to introduce policies to better support households at the edges of ownership that work across the board for debt-funded ownership-centred housing systems.

Originality/value
This paper extends the duration of a previous analysis of the impact of tenure transitions and financial transactions on well-being at the edges of ownership in the UK and Australia. The authors now track households over nearly two decades from the start of the millennium into a lengthy (post-global financial crisis) era of declining housing affordability. This study adds to the reach of the earlier study by adding a general health variable and a third jurisdiction, the USA.
Is transformational leadership always good for innovation? The moderating effect of transformational leadership on the personality–innovativeness link through knowledge sharing
Authors: Vo An H.K. , Nguyen Tuan-Duong , Le Yen-Nhi , Cao Huong Ngoc Quynh , Le Van Ngoc Thanh , Huynh Khanh-Linh 
Published: March 2023

Purpose
Based on the model of Big-Five personality traits and theories of person–environment interaction, this study aims to investigate the moderating effects of personality traits on innovativeness through knowledge sharing (KS).

Design/methodology/approach
A sample of 318 Vietnamese employees was collected. The hypothesized model was tested by using partial least squares structural equation modelling.

Findings
The results indicate that extraversion, agreeableness, conscientiousness and openness to experience have relationships with innovativeness through the mediating effect of KS. Furthermore, transformational leadership (TL) mitigates the positive relationship between agreeableness and openness to experience and innovativeness.

Practical implications
Based on the research results, the authors suggest several practical implications for enhancing employees' innovative organizational behaviours. Transformational leaders should be aware of and control the relationships with employees high in agreeableness and open to experience to ensure that employees' innovativeness can be freely developed.

Originality/value
This research systematically investigates the effect of each personality on employees' innovativeness. Furthermore, this study contributes to the leadership literature by suggesting the dark side of TL that can negatively influence the innovative ability of employees with certain personality traits.
Startup valuation reassessed: against celebrity, sustainability and state intervention
Authors: Hoffmann Christian Hugo 
Published: March 2023

Purpose
The purpose of this study is to showcase that the valuation of startups is still considered to be more “art than science”. Moreover, such non-rigorous approaches often lead to valuations, which turn out to be too high, which in turn has become a well-known phenomenon to a broader audience due to shining examples such as We Work. This is reason enough to revisit the important topic of where we stand today with startup valuation procedures and methodologies.

Design/methodology/approach
Literature synthesis and exploratory analysis.

Findings
While some studies describe sound results about how to assess startups, what the authors found was that many questions remain open or have not been covered at all. This is the reason why the authors needed to apply a substantial amount of reasoning in the analysis of studies, which do not exactly deal with startup companies. The authors provided some interesting impulses for future research.

Originality/value
Based on an original overview of the current state of research about the valuation of startup companies, this paper makes the following principal contribution to both the literature and practice: on the one hand, the authors assess four impact factors on startup values critically; on the other, the authors provide an outlook on promising future research avenues.
The leadership challenge of increasing productivity in the workplace without increasing burnout risk
Authors: Whiteoak John , Abell Daniel , Becker Karen 
Published: March 2023

PurposeThis paper aims to examine the critical question of how to increase productivity without also increasing the burnout risk. A systems thinking framework was applied to explore individual perceptions of team dynamics and how they relate to morale, work–life balance (WLB) and hours worked.Design/methodology/approachUsing an online survey, data from 1,222 Australian workers were analysed using hierarchical multiple regression and principal components analysis (PCA).FindingsSelf-reported productivity was found to be predicted by engagement whereas burnout and morale had minimal impact. Burnout risk was not related to hours worked but was reduced when WLB, quality work and trust is higher. Co-worker effort impacted morale and a factor labelled as team “sense of accomplishment” (SoA) was identified.Research limitations/implicationsThe results of this research have limited generalisability to wider populations due to sampling methods, being conducted in the Australian context and respondents coming from a diverse range of occupations. The sample being skewed towards younger age groups and the acknowledged use of single-item measures may also restrict drawing broader conclusions from the results.Originality/valueA socio-technical systems thinking model to diagnose the link between workplace burnout and productivity is applied. The approach involved understanding the importance of trust and how the connection between people and systems can influence morale.
Constructing the accurate forecast: an actor-network theory approach
Authors: Henttu-Aho Tiina , Järvinen Janne T. , Lassila Erkki M. 
Published: March 2023

Purpose
This paper empirically demonstrates the major organizational events of a rolling forecasting process and the roles of controllers therein. In particular, this study aims to investigate how the understanding of a “realistic forecast” is translated and questioned by various mediators in the rolling forecasting process and how it affects the quality of planning as the ultimate accuracy of forecasts is seen as important.

Design/methodology/approach
This study follows an actor-network theory (ANT) approach and maps the key points of translation in the rolling forecasting process by inspecting the roles of mediators. This qualitative case study is based on interviews with controllers and managers involved in the forecasting process in a single manufacturing company.

Findings
The paper identified two episodes of translation in the forecasting process, in which the forecast partially stabilized to create room for managerial discussion and debate. The abilities of controllers to infiltrate various functional groups and calculative practices appeared to be one way to control the accuracy of forecasting, although this was built on a façade of neutrality.

Originality/value
Prior literature identifies the aims of interactive planning processes as being to improve the quality of planning. The authors apply ANT to better understand the nature of mediators in constructing an entity called a “realistic rolling forecast”.
Brand equity and company performance: evidence from a quasi-experiment in an emerging market
Authors: Oliveira Marta Olivia Rovedder de , Sonza Igor Bernardi , da Silva Tamires Silva 
Published: March 2023

PurposeMarketing and brand managers are under more pressure than ever before to demonstrate the impact of the managers' strategies and actions on company value, especially in an emerging market. In this context, the authors investigate the relationship between brand equity and company performance using the rankings of most valued brands from Brand Finance (BF), Brand Analytics (BZ) and Interbrand (IB).Design/methodology/approachThe authors use used a panel from the period between 1990 and 2018 (29 years), consisting of a sample of 689 companies with shares traded in an emerging market representing 7,970 observations with unbalanced data. The authors applied a dynamic Differences-in-Differences Ordinary Last Squares (DID OLS) method.FindingsThe main finding of this study is that brands ranked as valuable significantly increased the brands' companies' intangible assets, return on assets, free cash flow (FCF) and market value.Research limitations/implicationsThe present study helps brand and marketing managers show to chief executive officers (CEOs) and shareholders the importance of brand development. In addition, valuable brand companies of an emerging market may represent an interesting opportunity for market investors.Originality/valueThis study contributes to the marketing literature, addressing the fields of marketing and finance, by analyzing the performance of companies separately over a long period, with different metrics, an unconventional model in the marketing area and different rankings of valuable brand names.