bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Mesenchymal Stem Cells Improve Angiogenesis and Bone Formation
in Severed Finger Rats through SIRT1/Nrf2 Signaling
Authors: Wu Hao , Sun Weixue , Cheng Gong , Zheng Mingdi , Zhao Yuchi , Cao Zhilin 
Published: May 2023

Background:
This study employed a severed finger rat model to analyze the effects of human
mesenchymal stem cells (MSCs) on angiogenesis, inflammatory response, apoptosis, and oxidative stress,
to evaluate the possible mechanism of the repair effect of MSCs on severed finger (SF) rats.

Methods:
Sixty Sprague-Dawley (SD) rats were categorized into five groups (n = 12). The pathological
changes of severed finger tissues were investigated by Hematoxylin and eosin (H&E) staining on day 14
after the rats were sacrificed. The levels of inflammatory factors and oxidative stress factors were detected
by ELISA. Terminal Deoxynucleotidyl Transferase (TdT) dUTP Nick End Labeling (TUNEL) was
employed to assess the apoptosis of chondrocytes in severed finger tissues. The expression of osteocalcin
(OCN), osteopontin (OPN), Collagen I (Col-1), and CD31 were detected by immunohistochemistry or
immunofluorescence assay, respectively. The expression levels of related proteins were determined by
western blot.

Result:
Our study presented evidence that MSCs treatment improved pathological changes of skin and
bone tissue, diminished the inflammatory response, prevented oxidative stress injury, suppressed chondrocyte
apoptosis, and promoted angiogenesis, and bone formation compared to the model group. In addition,
EX527 treatment attenuated the effect of MSCs, SRT1720 and ML385 co-treatment also attenuated
the effect of MSCs. Importantly, the MSCs treatment increased the expression of Sirtuin
1(SIRT1)/Nuclear factor erythroid2-related factor 2(Nrf2) relate proteins.

Conclusion:
Our study indicated that the mechanism of the effect of MSCs on a severed finger was related
to the SIRT1/ Nrf2 signaling pathway.
Fundamental Uses of Peptides as a New Model in Both Treatment and Diagnosis
Authors: Okasha Hend 
Published: May 2023

Abstract:An amino acid short chain is known as a peptide. Peptide bonds are the connections that hold the amino acids of a peptide together in a particular order. Characteristically, the shorter length of peptides helps to identify them from proteins. Different ways are used to classify peptides, including chain length, source of peptides, or their biological functions. The fact that peptides serve several purposes suggests that there is a foundation for improvement in peptide production and structure to enhance action. In addition, many patents on peptides for therapeutic and diagnostic approaches have been obtained. This review aims to give an overview of peptides used recently in treatment and diagnosis.
A Critical Review of Phytochemical, Pharmacological and Ethnomedicinal
Properties of Eryngium foetidum L.
Authors: Dutta Ayon , Majunder Raja , Banerjee Sabyasachi , Chakraborty Utsab , Bose Sankhadip , Chakraborty Pranabesh 
Published: May 2023

Abstract:
Eryngium foetidum L. is a biennial herb widely used in most tropical regions as a herb, and
in India, its use is essentially increasing as an aromatic spice and flavouring agent. The plant is widely
populated by Turkey, Southeast Asia, the Caribbean, Thailand, China, and others. This herb is becoming
more popular due to its traditional uses for various ailments. Reviews have been included in
peer-reviewed publications until 2020, published in English. 55 papers conveying E. foetidum-related
conformation were screened, with 30 articles proven relevant and requiring authentication knowledge
to build up this analysis paper. The information about 64 phytoconstituents is responsible for treating
diseases like analgesia and inflammation, hyperlipidaemia, tuberculosis, coagulation, tumours, malaria,
leishmaniasis, oxidation, etc. All specific knowledge must be gathered in one location, which
will also assist scientists in finding and emphasising the elements of the upcoming corner in order to
assess the importance of the plant being studied or to demonstrate its medicinal value.
The Efficacy of a Diet Low in Fermentable Oligo-, Di-, Monosaccharides, and Polyols in Irritable Bowel Syndrome Compared to Its “Real-world” Effectiveness: Protocol for a Systematic Review
Authors: Jent Sandra , Bez Natalie Sara , Catalano Loan , Rogler Gerhard 
Published: May 2023

Background
Irritable bowel syndrome (IBS) is associated with various gastrointestinal and nongastrointestinal symptoms and reduced quality of life. A diet low in fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs) is one therapeutic option for IBS. Although the efficacy of the low FODMAP diet has been reported in several systematic reviews, the efficacy-effectiveness gap of the low FODMAP diet has not yet been assessed.

Objective
This systematic review aims to compare the efficacy of the low FODMAP diet from efficacy randomized controlled trials (RCTs) with the effectiveness of studies conducted in “real-world” settings.

Methods
RCTs, prospective and retrospective cohort studies, and retrospective audits assessing the low FODMAP diet in adults with IBS will be searched in 4 databases: Embase, MEDLINE, CENTRAL, and CINAHL. Two independent reviewers will perform study selection, data extraction, and risk of bias assessment and assess selected quality aspects from the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) protocol. Outcomes assessed are stool frequency, stool consistency, abdominal pain, overall symptom scores, adequate symptom relief, IBS-specific quality of life, and diet adherence. Data will be summarized with forest plots without summary statistics, tables, and narrative descriptions.

Results
The search, title and abstract screening, and full-text screening were completed in March 2021, and an updated search was done in May 2022. As of May 2023, data analysis is almost finished, and manuscript writing is in progress. Submission of the manuscript is expected by July 2023.

Conclusions
The findings of this systematic review will compare the efficacy of the low FODMAP diet for IBS found in RCTs to the diet’s real-world effectiveness.

Trial Registration
PROSPERO CRD42021278952; https://tinyurl.com/32jk43ev

International Registered Report Identifier (IRRID)
DERR1-10.2196/41399
Evaluation of the EsteR Toolkit for COVID-19 Decision Support: Sensitivity Analysis and Usability Study
Authors: Alpers Rieke , Kühne Lisa , Truong Hong-Phuc , Zeeb Hajo , Westphal Max , Jäckle Sonja 
Published: May 2023

Background
During the COVID-19 pandemic, local health authorities were responsible for managing and reporting current cases in Germany. Since March 2020, employees had to contain the spread of COVID-19 by monitoring and contacting infected persons as well as tracing their contacts. In the EsteR project, we implemented existing and newly developed statistical models as decision support tools to assist in the work of the local health authorities.

Objective
The main goal of this study was to validate the EsteR toolkit in two complementary ways: first, investigating the stability of the answers provided by our statistical tools regarding model parameters in the back end and, second, evaluating the usability and applicability of our web application in the front end by test users.

Methods
For model stability assessment, a sensitivity analysis was carried out for all 5 developed statistical models. The default parameters of our models as well as the test ranges of the model parameters were based on a previous literature review on COVID-19 properties. The obtained answers resulting from different parameters were compared using dissimilarity metrics and visualized using contour plots. In addition, the parameter ranges of general model stability were identified. For the usability evaluation of the web application, cognitive walk-throughs and focus group interviews were conducted with 6 containment scouts located at 2 different local health authorities. They were first asked to complete small tasks with the tools and then express their general impressions of the web application.

Results
The simulation results showed that some statistical models were more sensitive to changes in their parameters than others. For each of the single-person use cases, we determined an area where the respective model could be rated as stable. In contrast, the results of the group use cases highly depended on the user inputs, and thus, no area of parameters with general model stability could be identified. We have also provided a detailed simulation report of the sensitivity analysis. In the user evaluation, the cognitive walk-throughs and focus group interviews revealed that the user interface needed to be simplified and more information was necessary as guidance. In general, the testers rated the web application as helpful, especially for new employees.

Conclusions
This evaluation study allowed us to refine the EsteR toolkit. Using the sensitivity analysis, we identified suitable model parameters and analyzed how stable the statistical models were in terms of changes in their parameters. Furthermore, the front end of the web application was improved with the results of the conducted cognitive walk-throughs and focus group interviews regarding its user-friendliness.
Machine Learning Model to Predict Assignment of Therapy Homework in Behavioral Treatments: Algorithm Development and Validation
Authors: Peretz Gal , Taylor C Barr , Ruzek Josef I , Jefroykin Samuel , Sadeh-Sharvit Shiri 
Published: May 2023

Background
Therapeutic homework is a core element of cognitive and behavioral interventions, and greater homework compliance predicts improved treatment outcomes. To date, research in this area has relied mostly on therapists’ and clients’ self-reports or studies carried out in academic settings, and there is little knowledge on how homework is used as a treatment intervention in routine clinical care.

Objective
This study tested whether a machine learning (ML) model using natural language processing could identify homework assignments in behavioral health sessions. By leveraging this technology, we sought to develop a more objective and accurate method for detecting the presence of homework in therapy sessions.

Methods
We analyzed 34,497 audio-recorded treatment sessions provided in 8 behavioral health care programs via an artificial intelligence (AI) platform designed for therapy provided by Eleos Health. Therapist and client utterances were captured and analyzed via the AI platform. Experts reviewed the homework assigned in 100 sessions to create classifications. Next, we sampled 4000 sessions and labeled therapist-client microdialogues that suggested homework to train an unsupervised sentence embedding model. This model was trained on 2.83 million therapist-client microdialogues.

Results
An analysis of 100 random sessions found that homework was assigned in 61% (n=61) of sessions, and in 34% (n=21) of these cases, more than one homework assignment was provided. Homework addressed practicing skills (n=34, 37%), taking action (n=26, 28.5%), journaling (n=17, 19%), and learning new skills (n=14, 15%). Our classifier reached a 72% F1-score, outperforming state-of-the-art ML models. The therapists reviewing the microdialogues agreed in 90% (n=90) of cases on whether or not homework was assigned.

Conclusions
The findings of this study demonstrate the potential of ML and natural language processing to improve the detection of therapeutic homework assignments in behavioral health sessions. Our findings highlight the importance of accurately capturing homework in real-world settings and the potential for AI to support therapists in providing evidence-based care and increasing fidelity with science-backed interventions. By identifying areas where AI can facilitate homework assignments and tracking, such as reminding therapists to prescribe homework and reducing the charting associated with homework, we can ultimately improve the overall quality of behavioral health care. Additionally, our approach can be extended to investigate the impact of homework assignments on therapeutic outcomes, providing insights into the effectiveness of specific types of homework.
Pacing Variation in Multistage Ultramarathons: Internet-Based Cross-Sectional Study
Authors: Fariod Mielad , Olher Rafael Reis , Sousa Caio Victor , Scheer Volker , Cuk Ivan , Nikolaidis Pantelis Theodoros , Thuany Mabliny , Weiss Katja , Knechtle Beat 
Published: May 2023

Background
Ultramarathon running is the most popular ultraendurance competition in terms of the number of races and runners competing annually worldwide; however, no study has compared pacing and performance over a long period.

Objective
This study analyzes the pacing of successful finishers and nonfinishers in multistage ultramarathons worldwide.

Methods
A total of 4079 athletes (men=3288; women=791) competing in 99 multistage ultramarathon events from 1983 to 2021 were analyzed, including the number of participants, age, gender, rank, and running speed of successful finishers.

Results
The results showed a significant increase in the number of events (n=338) and a significant increase in the number of finishers and nonfinishers (n=5575) in the ultramarathons worldwide during this period. The general linear models (GLMs) of pacing variation showed nonsignificant effects for gender (F1,36.2=2.5; P=.127; ηp2=0.063) and age group (F10,10=0.6; P=.798; ηp2=0.367), but it showed a significant interaction (gender × age) effect (F10,2689=2.3; P=.008; ηp2=0.009). Post hoc analyses showed that men have a higher pacing variation than women in the under 30 years (U30), U35, U45, and U50 groups. Additionally, the fastest women’s age group (U35) had the lowest pacing variation. The GLM of pacing variation by gender and event distance showed significant effects for both gender (F1,3=18.5; P<.001; ηp2=0.007) and distance (F2,3=20.1; P<.001; ηp2=0.015). Post hoc analyses showed a growing pacing variation with increasing race distance for both men and women. In addition, men had a higher variation in long events. Furthermore, there was a significant main effect for both genders (F1,3=33.7; P<.001; ηp2=0.012) and rank (F1,3=136.6; P<.001; ηp2=0.048) on performance, with men being faster than women. Pacing varied greatly due to gender (F1,3=4.0; P=.047; ηp2=0.001), with a lower (ie, more even) pacing variation for male athletes in the top 3 finishers. Male nonfinishers showed a higher performance than female nonfinishers (F1,1340=25.6; P<.001), and no difference was identified for pacing variation (F1,789=1.5; P=.228) based on gender. In addition, a weak but significant correlation (r=–0.130; P<.001) was identified between the average running speed and pacing variation for both female and male nonfinishers.

Conclusions
In summary, multistage ultramarathon competitions showed an increasing number of competitors and a higher performance challenge. Men have a higher pacing (ie, less even) variation than women, especially observed in longer events. A higher pacing variation was associated with lower performance for men, women, and nonfinishers.
DEEP BITE MALOCCLUSION: EXPLORATION OF THE SKELETAL AND DENTAL FACTORS
Authors: Alaklany Baleegh Abdulwahab Galeb Ahmed , Almotareb Fuad Lutf , Albaham Strallah Hussin Abdullah , Al-Shamahy Hassan Abdulwahab , Al-hamzi Amani Hussein Y 
Published: May 2023

Background and objective: A deep bite malocclusion may be due to skeletal and dental factors. The analysis of the etiological factors may have an influence on the treatment plan. The aim of this study was to exploration the most common dental and skeletal factors that contribute to deep bite malocclusion in Yemeni individuals, as well as the correlations between them.
Material and methods: a cross-sectional prospective study was conducted to evaluate 136 individuals with deep bites using study casts and lateral cephalometrics (62 males and 74 females), with ages ranging from 18 to 28 years, with the Onyx program used for analysis. The recorded data was collected, tabulated, and statistically analyzed by SPSS.
Results: The Gonial angle and Jarabak index form the highest contribution to skeletal deep bite (59.3%), and the least contributing factors were the decreased saddle angle (3%), followed by decreases in the inclination angle) Pn line- PP) (11.1%). On the other hand, the most contributing dental factor to the deep bite was an exaggerated curve of spee (63.5%), followed by a decreased clinical crown length of the Lower first molar (52.6%), and the least contributing dental factor was an increased clinical crown length of the maxillary incisors. There was more correlation between skeletal factors than dental factors.
Conclusion: Deep bite malocclusion was characterized mostly by counterclockwise rotation of the mandible and increased spee curve. Understanding the most common dental and skeletal contributors will help clinicians treat patients with deep malocclusions more successfully.

Peer Review History:
Received: 4 February 2023; Revised: 11 March; Accepted: 28 April 2023, Available online: 15 May 2023
Academic Editor: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Rola Jadallah, Arab American University, Palestine, rola@aauj.edu
Dr. Khaled A AL-Haddad,Orthodontics, Pedodontics and Prevention Department Faculty of Dentistry, Sana'a University, Yemen, ya_haddadi@yahoo.com
SEROEPIDEMIOLOGY AND RISK FACTORS OF HEPATITIS B VIRUS IN JIBLAH TOWN, YEMEN
Authors: Al-Mohani Sadiq Kaid 
Published: May 2023

Aims and objective: Viral Hepatitis is a major global health problem affecting millions of people worldwide. The endemicity of hepatitis B virus infection believed high in Yemen. Data for prevalence of hepatitis B virus in Jiblah town in Yemen are rare and inadequate. Therefore, this study aimed to assess the seroprevalence of Hepatitis B virus and associated risk factors aming the general population of Jiblah town, Yemen.
Methods: A total of 100 participated included in this study. Serum samples were collected and assayed for HBsAg using the ELISA quantitative technique. A structured questionnaire was used to collect behavioral and sociodemographic data.
Results: the results revealed that, the seroprevalence of hepatitis B virus was 3.33%. There was statistically significant differences between hepatitis B virus infection and monthly income.
Conclusion: The finding of this study indicated that the magnitude of hepatitis B virus infection among the general population was intermediate level. Modifiable risk factor, monthly income was identified.

Peer Review History:
Received: 19 February 2023; Revised: 8 March; Accepted: 26 April 2023, Available online: 15 May 2023
Academic Editor: Dr. Rola Jadallah, Arab American University, Palestine, rola@aauj.edu
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Prof. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye
Dr. Wadhah Hassan Ali Edrees, Hajja University, Yemen, edress2020@gmail.com
PENGEMBANGAN MEDIA PODCAST TERHADAP KEPERCAYAAN DIRI SISWA SMP MUTIARA 4 BANDUNG
Authors: Azhari Nafitrian , Hidayat Wahyu , Suherman Maya Masyita 
Published: May 2023

The development of podcasts on the self-confidence of SMP Mutiara 4 Bandung students is a new innovation in guidance and counseling service activities using media that keep up with the times. The indicator of self-confidence according to the theorist, namely Lauster, becomes an urgency for students in the future. This study uses research and development methods by Borg and Gall which aims to produce products that have been tested by several validators, namely material experts, media experts, and practitioners. The research subjects consisted of 10 students for the limited trial, and 20 students for the wide trial, all of them were students of SMP Mutiara 4 Bandung who had problems in self-confidence. Based on the results of product testing by several validators, this podcast has an average percentage of 93.19% which according to predetermined criteria that the product is very suitable for use without revision. The results of observations and interviews with teachers and students showed high enthusiasm for the development of this podcast and the students had the ability to increase their understanding of self-confidence after conducting guidance and counseling activities using this podcasts.Â Keywords: Media, Podcast, Self Confidence.
LAYANAN BIMBINGAN KELOMPOK SECARA DARING MELALUI TEKNIK DISKUSI KELOMPOK UNTUK MINAT BELAJAR SISWA KELAS VII SMPN 2 PURWAKARTA
Authors: Machmud Elyta Yustika , Hendriana Heris , Alawiyah Tuti 
Published: May 2023

This study is based on the impact of the COVID-19 pandemic on implementation of Guidance and Counseling services in schools. Group guidance services given to students who have low learning interest problems. To assist online group guidance services, group discussion techniques are needed. This study used a qualitative research method. The data collection used was observation, interviews, and documentation. The subjects of this study were amount 5 students who had problems with low interest in learning. As a results obtained after providing online group guidance service using the group discussion technique there are changes in students. Based on research that online group tutoring services through group discussion techniques are effective in increasing the learning interest of class VII students of SMPN 2 Purwakarta.Â Keywords:Interest in Learning, Techniques of Group Discussions, Group counseling onlineÂ
BIMBINGAN PRIBADI-SOSIAL BERBASI ZOOM MEETING UNTUK KONSEP DIRI POSITIF PESERTA DIDIK SMP KELAS IX
Authors: Yuliana Selly Rizky , Hidayat Wahyu , Fatimah Siti 
Published: May 2023

ThisÂ researchÂ Â isÂ Â motivatedÂ byÂ Â theÂ Â existenceÂ ofÂ Â aÂ Â negativeÂ self-conceptÂ Â inÂ Â classÂ IXÂ Â students.Â Â ThisÂ isÂ Â indicatedÂ Â byÂ theÂ Â behaviorÂ Â thatÂ isÂ Â notÂ Â inÂ accordanceÂ Â withÂ Â theÂ behaviorÂ Â ofÂ Â studentsÂ atÂ Â school.Â Â ThisÂ studyÂ Â usesÂ Â aÂ qualitativeÂ Â descriptiveÂ Â methodÂ withÂ Â theÂ Â aimÂ ofÂ Â describingÂ Â theÂ implementationÂ Â ofÂ Â pribadi-socialÂ Â guidance.Â TheÂ Â resultsÂ Â ofÂ theÂ Â researchÂ Â obtainedÂ inÂ Â theÂ Â implementationÂ Â ofÂ pribadi-socialÂ Â guidanceÂ Â usingÂ aÂ Â zoomÂ Â meeting,Â namelyÂ Â planningÂ Â firstÂ thenÂ Â carryingÂ Â outÂ servicesÂ Â throughÂ Â severalÂ stagesÂ Â suchÂ Â asÂ problems,Â Â diagnosis,Â Â prognosis,Â therapyÂ Â andÂ Â evaluationÂ andÂ Â follow-up.Â Â ThisÂ canÂ Â beÂ Â seenÂ fromÂ Â inappropriateÂ Â behaviorsÂ suchÂ Â asÂ Â notÂ likingÂ Â criticism,Â Â withdrawingÂ fromÂ Â friendsÂ Â andÂ notÂ Â understandingÂ Â himself,Â hisÂ Â family,Â Â andÂ theÂ Â peopleÂ Â aroundÂ him.Â Â SocialÂ Â interactionÂ isÂ Â alsoÂ Â hamperedÂ andÂ Â makesÂ Â itÂ difficultÂ Â forÂ Â theseÂ studentsÂ Â toÂ Â developÂ theirÂ Â potentialKeywords:Â Pribadi-SocialÂ Â Guidance,Â Â Self-Concept,Â ZoomÂ Â Meeting,Â Â Learners
GAMBARAN KEPERCAYAAN DIRI SISWA SMK ALOER WARGAKUSUMAH
Authors: Mutaharoh Silmi , Hendriana Heris , Supriatna Ecep 
Published: May 2023

Self Confidence is something that is need by an individual. This study aims to describe the confidence profil of the Aloer Wargakusumah Vocational High School students. The method used in this research is descriptive quantitative, with the number of subjects as many as 102 students of class XI SMK Aloer Wargakusumah. The results showed that the level of self confidence was high at 15%, low at 71% and moderate at 13%, which had aspects of self confidace that were 80% confident in their abilities 83%, optimisic 86%, responsible, 76%, rasional and realistic 72%. Meanwhile, based on gender the cnnfidence level of women is higher than that of me, in the female gendeer self confidence dominates with a value of 55% an menas much as 45%. Thus SMK Aloer wargaksumah student generally have moderate.Â Keywords:Â Â Â Self confidence, StudentsÂ