bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological Potential of Thiazolidinedione Derivatives: A Review
Authors: Prabakaran M  
Published: March 2023

Background: The authors of the current review aspire to inspire researchers by using the SAR technique to discover a promising and novel therapeutic agent. Currently, we don’t have a drug that is both active and non-toxic for the treatment of severe diseases like cancer, diabetes, hypertension, and neurodegenerative diseases. In a summary, thiazolidinedione (TZD) heterocyclic ligands have a spectacular standing in medicinal chemistry's synthetic and pharmacological approaches. Thiazolidinedione (TZD) core upon the replacement of different substitutes, gives a wide range of organic action by the utilization of various components on various objective destinations.
Methods: We looked through the logical data set utilizing relevant keywords. Among the looked through writing, certain research papers were gathered which resolved our inquiries. The vital discoveries of the key findings of these studies were incorporated alongside their significance.
Results: There has been an explosion in the introduction of new classes of pharmacological agents having Thiazolidinedione moieties. Subsequently, new medications with Thiazolidinedione moieties came up with improved compliance and reduced side effects.
Conclusion: The present review describes the significance of the Thiazolidinedione nucleus and its derivatives as a therapeutic agent with an emphasis on the past as well as recent developments.
“Molecular Characterization And Its Association To Ap Endonuclease-1 (Ape1) And X-Ray Cross-Complementing Group 1 (Xrcc1), As A Dna Repair Protein From Patients With The Risk Of Age-Related Cataract At A Tertiary Care Centre, Uttar Pradesh”
Authors: Dr. Mohammad. Ashraf Khan  
Published: March 2023

Introduction: Age-related cataract is the leading cause of blindness in the world. (AP)-endonuclease APE1 and the X-ray cross-complementing group 1 (XRCC1) are the key enzymes taking part in the repair of DNA damage. The association of X-ray cross-complementing group 1 (XRCC1) and AP endonuclease-1 (APE1) plays a critical role as polymorphisms of DNA repair genes decreasing the ability to repair DNA damage, leaving human body a greatly increased susceptibility to cancer or age-related diseases.
Aim and objective: To study the Molecular characterization and its Association to AP endonuclease-1 (APE) and X-ray cross-complementing group 1 (XRCC1), as a DNA Repair protein from patients with the risk of age-related cataract at a Tertiary Care Centre, Uttar Pradesh.
Material and methods: This was a case control study carried out in the Department of Anatomy & Department of Ophthalmology of RMCH&RC for a period of 2 year i.e., June 2020 to June 2022. A total of 500 clinical suspected cases were included in our study in which 250 patients were confirmed as cataract positive patients whereas 250 were the Controls. The Demographic profiles of the cases were recorded after duly obtaining consent. The 5ml of venous blood was collected in Ethylene diamine tetraacetic acid tubes.
DNA was extracted by using Qiagen DNA Extraction kit as per manufactures guidelines. The AP endonuclease-1 (APE) and X-ray cross-complementing group 1 (XRCC1) gene was detected by the conventional PCR.
Results: In the present study the maximum number of cases were reported in the Females as compared to the Males with the maximum age group of 51-60 years being affected the most. The Expression of (AP) –endonuclease (APE1) gene was more 68.4 % as compared to X-ray cross-complementing group 1 (XRCC1) with 62.8 %. The increase expression indicates the presence of these genes in the DNA repair damage.
Conclusion: The Expression of (AP)-endonuclease (APE1) gene was more 68.4% as compared to X-ray cross-complementing group 1 (XRCC1) with 62.8%. The increase expression indicates the presence of these genes in the DNA repair damage. So, there should be early screening and its molecular detection of the DNA repair gene, which will help the clinician in the early diagnosis as well as early treatment of the cataract.
ATUAÇÃO DO OPTOMETRISTA NA PRESCRIÇÃO DE PRISMAS
Authors: Gonçalves Costa Janaíne , Trentin Sonoda Rodrigo 
Published: March 2023

O prisma é um meio transparente, com definido índice de refração (n) delimitado por duas superfícies não paralelas que possuem o poder de desviar para a base os raios de luz refratado. É usado em instrumentos ópticos como: biomicroscópio, tonômetro de aplanação, ceratômetro de Javal, sistema de Kepler, medir desvios, lentes dióptricas, avaliação de forias verticais, paresias capacidades musculares, forias horizontais, terapias visuais, tratamento de diplopia, estrabismo, ambliopia, hemianopsia, nistagmo e postural, paciente com TDAH - Transtorno do Déficit de Atenção com Hiperatividade, TEA - Transtorno do Espectro Autista, tratar a DMRI – Degeneração Macular Relacionada a Idade. Através de revisão bibliográfica e de artigos publicados, busca-se elucidar a conduta optométrica para a aplicação dos prismas, em disfunção visual, postural, neurológica juntamente com uma equipe multidisciplinar.
Research on Dynamic Alternating Current Corrosion Behavior of X65 Pipeline Steel Under Cathodic Protection
Authors: Chen Le , DU Yanxia , Liang Yi , Tian Nianpei , Zhu Zhenhong , Zhang Lei 
Published: March 2023

An indoor corrosion simulation experiment device was built to explore the influence of dynamic alternating current (AC) interference on the corrosion behavior of pipeline steel under different cathodic protection (CP) levels. When the interference time in each interference cycle is 350 s, the dynamic AC corrosion rate was comparable to the steady AC corrosion rate. For JAC of 30 A/m2, the corrosion rate of the specimen can be controlled below 0.0254 mm/y when the CP current density is higher than 0.06 A/m2. As JAC is greater than or equal to 100 A/m2, with the increase of the CP current density, the corrosion rate of the specimens decreased first, then increased and decreased again. In this paper, the real-time AC/DC potential on the surface of the specimen is monitored, combined with the Pourbaix diagram and the evolution of corrosion product film. The dynamic AC corrosion mechanism under different CP levels was explored.
Optimization of Mn-Al-P Chemical Conversion Coating for a Process Sequence Adjusted Low Sn-Coated Steel
Authors: Zhao Yinghai , Li Wei , Wang Zhenwen , Li Ning , Xu Yanling , Li Deyu 
Published: March 2023

In recent years, in the field of tinplate production, it has become a trend to use lower tin coating mass to lower production costs. However, the preparation of low Sn-coated steel must face two significant problems: toxic chromate post-treatment and low corrosion resistance. In this work, we developed an Mn-Al-P chemical conversion coating using a process sequence-adjusted tinplate of 0.5 g/m2 tin coating mass as an alternative to the chromate treatment. Meanwhile, by adjusting the subsequence of the reflowing process and the post-treatment process, the wash water and electricity consumption were effectively reduced. The influence of reflowing time on the microstructural appearance, phase composition, surface element distribution, and corrosion resistance of this new brand tinplate was studied. Moreover, the composition was determined by x-ray photoelectron spectroscopy, and further discuss the formation mechanism of this coating. The results show that this mutielement coating could effectively fill tin-free zones on the surface of the tinplate and improve the corrosion resistance when the reflowing time is properly set up to 3.5 s after the process adjustment. However, continually extending the reflowing time would cause the phosphate coating to fall off, leading to the corrosion resistance deterioration. The coating was mainly made up of a series of amorphous phosphate compounds and metal oxides, which was suitable for a tinplate with low tin coating mass.
Association of Reproductive Parameters with Dermatoglyphics in Breast Cancer Patients, Healthy and High-Risk Individuals
Authors: Rangan Rahul , Shedge Swapna , Kakade Satish 
Published: March 2023

Background
Breast cancer has a wide array of risk factors, and its confounding reproductive aetiologies have been paramount in defining the predictive ability of the disease. Similarly, a strong link between qualitative dermatoglyphic patterns and predisposition to breast cancer has been well documented through genetic linkage. Therefore, this study aimed to discern the affiliation between the aforementioned risk factors of breast cancer.

Methods
The study was carried out in 3 groups of 90 age-matched individuals of - breast cancer patients, high-risk individuals and healthy individuals. A detailed reproductive history was taken including factors such as age at menarche, menstrual regularity, age at menopause (if attained), breastfeeding, obstetric parameters and age at first live birth. Qualitative dermatoglyphics were procured through the standardised ink and paper method to get a remarkable rolled fingerprint. The variations in gynaecological and obstetric parameters and qualitative dermatoglyphic patterns were studied and their significance was computed using the chi-square test on InStat software where p values < 0.05 were considered significant with a 95% confidence interval.

Results
Highly significant values (p<0.0001) were found in all gynaecological and obstetric parameters where a higher frequency of whorls in breast cancer patients, arches in high-risk individuals and an equivalent frequency of arches and whorls were predisposed to healthy individuals.

Limitations
Although this study might have identified certain predominating patterns with higher frequency, the consistency might vary from place to place due to differing dermatoglyphics according to ethnicity.
A small number of patients receiving chemotherapy experienced - chemotherapy-induced adermatoglyphia - where the loss of fingerprints or very faint fingerprints was difficult to perceive. These patients were not included in the study to ensure maximum efficacy in interpreting the dermatoglyphics.

Conclusion
Previous attempts failed to link dermatoglyphic indices and reproductive parameters, this study found a significant correlation between the variables in the three distinct groups. Most breast cancer patients are diagnosed late with a majority presenting to doctors in advanced stages where survival rates are marginal, so by this method, we can get a simple, practical, non-invasive and easily affordable screening technique for the above risk factors. This technique could also be employed for non-symptomatic women who might have a positive family history of breast cancer as a part of risk assessment for early diagnosis and treatment. Therefore, paving way for further research into the prognostic abilities of gynaecological parameters through qualitative dermatoglyphic indices.
The Prevalence of Frank’s Sign and the Diagnostic Accuracy in Coronary Artery Disease Among Chest Pain Patients at Lampang Hospital, Thailand
Authors: Thammasaranggoon Kanjanaporn , Khanthamoon Narawish , Sangphet Pitsinee , Pattamapornpong Aookrit , Chotechuang Yotsawee , Srisubin Maytinee , Ninwaranon Somluck , Huntrakul Jakkrawal 
Published: March 2023

Background: One of the leading cause of death in Thailand is coronary artery disease (CAD). There are several studies that demonstrated a significant correlation between diagonal earlobe creases (DELC) or Frank’s sign and CAD, but data in Thai populations still remains unclear. Because of Frank’s sign is easily to observe by health-care professional including medical students, so it was very interesting to use to identify risk of atherosclerosis of the patients in hospital which has limitation of resources. The purpose of the study was to assess the prevalence of Frank’s sign and evaluate the diagnostic accuracy in CAD among the angina chest pain patients at Lampang Hospital.
Methods: This study was a cross-sectional, observational, study. Three hundred and nine patients with angina chest pain who underwent coronary angiography (CAG) and followed up at the coronary clinic at Lampang Hospital were enrolled in the study. Both ears of the patients were inspected for Frank’s sign. The accuracy of Frank’s sign was confirmed by three cardiologists and clinical data was collected in medical record form. We excluded the patients whose earlobe could not be clearly observed, including those with keloid/ulcer on the earlobe or those with no earlobe. The correlation of Frank’s sign and CAD were analyzed by using logistic regression and receiving operative curve (ROC) curve.
Results: 64.4% of the angina chest pain patients (N=199) have demonstrated for Frank’s sign, unilateral Frank’s sign in 12.3% (N=38) and bilateral Frank’s sign in 52.1% (N=161). Twenty-one patients (6.8%) were normal CAG and 288 patients (93.2%) were significant CAD, single vessel disease CAD (N=86), double vessel disease CAD (N=83) and triple vessel disease CAD (N=119). The diagnostic accuracy of the Frank’s sign revealed that 64.6% for the sensitivity and 38.1% for the specificity. Besides, the positive predictive value (PPV) was 0.935 and for negative predictive value (NPV) showed 0.073. Nevertheless, the positive likelihood ratio (LR+) was 1.032 and 0.947 for the negative likelihood ratio (LR-). Moreover, the area under the curve (AuROC) of Frank’s sign with respect to detection of CAD was 0.513 (95% Confidence Interval was 0.385-0.642, P= 0.838).

Conclusion: Frank’s sign was observed in two-third of angina chest pain patients at Lampang Hospital and mostly of the patients with Frank’s sign were significant CAD. The results of this study showed that Frank’s sign was a simple, non-expensive and non-invasive method for medical student and health-care professional to identify risk of CAD.
Czy polska socjologia wsi ma przyszłość? Recenzja książki Andrzeja Kalety, Szkice o polskiej socjologii wsi
Authors: Najbor Joanna 
Published: March 2023

Recenzja książki: A. Kaleta, Szkice o polskiej socjologii wsi, Wydawnictwo Naukowe Uniwersytetu Mikołaja Kopernika, Toruń 2021, ss. 215.
Predictors of Length of Care in Tibial Fracture Patients: Analysis of Secondary Data
Authors: Hakam Mulia , Pratama Fernanda Reza , Ridla Akhmad Zainur 
Published: March 2023

Introduction: Predicting the length of care becomes important for intervention in the care system. However, it still seems that the ability to predict the length of treatment is not optimal, so that the length of treatment is prolonged. If the ability to predict the length of treatment can be done optimally, it will improve the patient's return time.
Methods: This study uses a retrospective study approach.
Result: There was no relationship between the predictor of length of stay with a length of treatment.
Conclusion: The predictor of length of stay in this study were patients with tibia fractures at RSD dr. Soebandi. Most of the patients with tibial fractures were in the early elderly, with the gender of patients with tibia fractures being mostly male. Most of the patients with tibial fractures have no complications and the type of fracture in patients with tibia fractures is mostly in the fracture of the shaft of the tibia. There was no correlation between the predictors of length of stay and length of stay in patients with tibia fractures.
Entrevista: Dinasalda Santana de Ceita
Authors: Ferracini Rosemberg 
Published: March 2023

Dinasalda Santana de Ceita nasceu em São Tomé e Príncípe, aos seus 20 anos, com um grupo de jovens da ilha, foi para universidade em Moçambique. Onde viveu durante 15 anos. Actualmente está em Portugal é doutoranda em Alterações Climáticas e Políticas de Desenvolvimento Sustentável pelo Instituto de Ciências Sociais da Universidade de Lisboa e pela Faculdade de Ciências Sociais e Humanas– NOVA FCSH. É Geógrafa e pesquisadora no tema da População e Desenvolvimento pela Universidade Eduardo Mondlane, Moçambique. Foi coordenadora nacional por 4 anos através do PNUD e Ministério de Agricultura, São Tomé e Príncipe do projeto “Reforço das capacidades das comunidades rurais para a adaptação aos efeitos das mudanças climáticas em São Tomé e Príncipe” financiado pelo Fundo Global para o Ambiente. As suas principais investigações têm se concentrado na Migração e Género, Mudança Climática, Agricultura e Género, Adolescentes e HIV.
Kajian Teologis atas Konsep Otoritas dalam Matius 25:14-30 dan Refleksinya bagi Kepemimpinan Gereja Era Digital
Authors: Arifianto Yonatan Alex , Anjaya Carolina Etnasari , Joswanto Andreas 
Published: March 2023

Every leader, including the church leaders, always had the authority to carry out his functions and duties. However, some facts showed that the leaders misused the authority for the benefit of themselves or their groups. This study provided an understanding of the term authority found in the text of Matthew 25:14-30 and its reflections for the church leaders in the digital era. The method of the study was a literature study approach, using literature from various sources with relevant themes. The results showed that according to Matthew 25:14-30, there were five main principles needed to carry out authority, namely: one, human’s authority belonged to God and was entrusted to be used for a purpose. Two, the authority of the leaders was used for His glory, according to His plans and purposes. Three, authority was a proof that God gave men freedom of action. Four, trust and loyalty were the developers of authority. Five, authority always contained demands for responsibility to God. These five principles made the core of implementations to establish a Divine-quality self which became the main key of today's church leaders. AbstrakSetiap pemimpin, termasuk pemimpin gereja, selalu memegang otoritas dalam menjalankan fungsi dan tugasnya. Namun terdapat berbagai fakta yang menunjukkan bahwa para pemimpin menyalahgunakan otoritas terebut demi kepentingan diri atau kelompok. Kajian ini memberikan pemahaman tentang otoritas yang terdapat dalam teks matius 25:14-30 dan refleksinya bagi para pemimpin gereja di era digital. Metode kajian ini menggunakan pendekatan studi pustaka dari berbagai literatur dengan tema relevan. Hasil penelitian menunjukkan bahwa sesuai kajian Matius 25:14-30 ditemukan bahwa dalam sebuah otoritas termuat lima prinsip utama yang perlu dilakukan dalam menunaikan otoritas yaitu: satu, otoritas manusia adalah milik Tuhan yang dipercayakan untuk dipergunakan dengan suatu tujuan. Dua, otoritas pemimpin dipergunakan bagi kemuliaan-Nya, sesuai rencana dan tujuan-Nya.Tiga, otoritas sebagai bukti bahwa Tuhan memberikan kebebasan bertindak pada manusia. Empat, kepercayaan dan kesetiaan adalah pembangun otoritas. Lima, dalam otoritas selalu termuat tuntutan pertanggungjawaban kepada Tuhan Lima prinsip tersebut menghasilkan inti implementasi yaitu membangun diri berkualitas Ilahi menjadi kunci pokok para pemimpin gereja di masa kini. dalam menjalankan tugas kepemimpinan di era digital.Kata Kunci: Konsep Otoritas; Otoritas Kristen; Kepemimpinan Kristen; Otoritas Kepemimpinan
Strategi Misi Penginjilan Yesus: Sebuah Studi Eksposisi Matius 9:35-37
Authors: Purdaryanto Samuel , Hariyanto Hariyanto , Poluan Deice Miske 
Published: March 2023

A mission is the sending of a church for believers to preach the gospel in the midst of the world to the unbelievers. The implementation of the mission can be realized properly, a strategy or steps are needed to achieve the goal. From the existing data, in Indonesia alone there are still 131 neglected tribes who have not heard the gospel news. Looking at this data, the mission strategy of preaching the gospel is still very much needed to increase the number of existing evangelistic mission strategies. This research uses a qualitative approach with descriptive analysis methods through exposition studies. The author conducted an expositional study of the Gospel of Matthew 9:35-38 with the OIA model (observation, Intepretation, Application), to find a mission strategy for preaching the gospel of Jesus. The results of this study found a mission strategy for preaching the gospel of Jesus which is divided into three steps. Compassion as the basis of the strategy of preaching the gospel, moving to reach all places, and preaching and teaching. These findings encourage every Christian to become more active in missionary ministry. ABSTRAKMisi merupakan pengutusan gereja bagi orang percaya untuk memberitakan Injil di tengah dunia kepada mereka yang belum percaya. Pelaksaan misi dapat terealisasi dengan baik, diperlukan strategi atau langkah-langkah untuk mencapai tujuan tersebut. Dari data yang ada, di Indonesia saja masih terdapat 131 suku terabaikan yang belum mendengar berita Injil. Melihat data ini, strategi misi pemberitaan Injil masih sangat diperlukan untuk menambah jumlah strategi misi penginjilan yang sudah ada. Penelitian ini menggunakan pendekatan kualitatif dengan metode analisa deskriptif melalui studi eksposisi. Penulis melakukan studi eksposisi terhadap Injil Matius 9:35-38 dengan model OIA (observasi, Intepretasi, Aplikasi), untuk menemukan strategi misi pemberitaan Injil Yesus. Hasil penelitian ini menemukan strategi misi pemberitaan Injil Yesus yang dibagi dalam tiga langkah. Belas kasih sebagai dasar strategi memberitakan Injil, bergerak menjangkau segala tempat, serta memberitakan dan mengajar. Temuan ini mendorong setiap orang Kristen untuk semakin giat dalam pelayanan misi. Kata-kata kunci: Misi; Strategi, pemberitaan; belas kasihan; mengajar
AKU TELAH SEMBUH: Pengalaman Doktrinal sebagai Kenyataan Sosio-Teologis Pantekosta
Authors: Tambunan Elia , Duha Sang Putra Immanuel 
Published: March 2023

This article is written in a social research landscape with Pentecostal theology, namely divine healing as an object of study, by using a critical study method of literary sources, including social media. The question to be answered for the academic field in Indonesia is how to modernize theology as a science that integrates with social science. So far there is a scientific problem. The Bible as the main object of study is too focused on the analysis of biblical texts. Science in these institutions seems to be ignorant of social praxis. The Bible contains narratives of the experience, and history of tribes, societies, and nations. We build our meaning of social theories with systematic theology to produce a theoretical framework. The findings, "I have been healed", not only as a theological expression but has a broad social impact. Through it, we contribute a framework of Pentecostal socio-theological reality to the study of global Pantecostalism which is useful as an empirical working tool in understanding the experiences of biblical text societies and contextual societies. ABSTRAKIni adalah tulisan dalam lansekap penelitian sosial dengan teologi Pantekosta yakni kesembuhan Ilahi sebagai objek kajian, dilakukan dengan metode studi kritik sumber literatur, termasuk media sosial. Pertanyaan yang hendak dijawab untuk ladang akademik di Indonesia, bagaimana cara untuk memodernisasi teologi sebagai ilmu mengintegrasikan dengan sosial sains? Sejauh ini memang ada problem keilmuan. Alkitab sebagai objek utama dari studi terlalu berkutat pada analisis teks biblis. Keilmuan dalam institusi tersebut terkesan abai dengan praksis sosial. Padahal, Alkitab memuat narasi pengalaman, sejarah puak-puak, masyarakat, bangsa-bangsa. Kami membangun pemaknaan sendiri atas teori-teori sosial dengan teologi sistematika untuk menghasilkan kerangka teori. Dalam temuan kami, “aku telah sembuh”, tak hanya sebagai ungkapan teologis tetapi memiliki impak sosial luas. Lewat temuan, kami menyumbangkan kerangka pikir kenyataan sosio-teologis Pantekosta untuk studi Pantekostalisme global yang berguna sebagai alat kerja empiris dalam memahami pengalaman masyarakat teks biblis dan masyarakat kontekstual. Kata Kunci: Kenyataan Sosio-Teologis; Pantekosta; Pengalaman Doktrinal; Teologi Sistematika