bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penentuan Rute Terpendek Di Kantor Pos Kabupaten Blitar Dalam Pendistribusian Paket Menggunakan Algoritma Clarke And Wright Savings
Authors: Puji Wianto Wildan Faried Anshoriy , Juhari Juhari , Nasichuddin Achmad 
Published: September 2023

Marketing strategy is a very important part in the execution of the overall corporate strategy, especially in a very tight competitor state. Route is a very important aspect considered by goods distribution companies. An effective and efficient distribution process is one of the factors whose conditions begin to align with other indicators in an effort to achieve customer satisfaction. The strategy that can be done is to involve calculating algorithms in contributing systematic and measurable solutions. The Clarke and Wright Savings algorithm is an effective method in determining the shortest route of distributing goods, because the Clarke and Wright Savings method has its own heuristics which make savings in the form of mileage or distribution time. This study aims to determine the shortest route at the Blitar checkpoint post office (KPRK) in distributing express service type bags to each branch post office point (KPC) using the Clarke and Wright Savings Algorithm. The results of the discussion on the application of the Clarke and Wright Savings method to determine the shortest route for the service bag distribution fleet from the KPRK Blitar post office to KPC can be concluded that, there are two initial routes owned by the company with a total delivery distance of 189.7 km. After calculation, two routes with the shortest distance will be traveled with a total delivery distance of 171 km. Route group 1 is Blitar Post Office à KPC Garum à KPC Nglegokà KPC Gandusarià KPC Talun KPC Wlingi à KPC Doko à KPC Kesamben à KPC Selopuroà KPC Binangun à KPC Kanigoro à KPC Lodoyo à KPC Kademangan à Post Office with a distance of 116.7 km. As for route 2, namely the blitar post office à KPC Sanan Kulon à KPC Ponggok à KPC Srengat à KPC Kademangan à KPC Udanawu à Blitar post office with a distance of 54.3 km. With the establishment of routes with the closest distance, the company can save mileage by 9.85%.
L’agroforesterie en contexte post-forestier : perspectives et controverses d’une mise à l’agenda politique en Côte d’Ivoire
Authors: DI ROBERTO Hadrien , MILHORANCE Carolina , SOKHNA DIENG Ndèye , SANIAL Elsa 
Published: September 2023

En Côte d’Ivoire, l’agroforesterie devient une notion incontournable après une déforestation massive pour les cultures de plantation. Depuis les années 2010, le terme se généralise dans le vocabulaire politique, les normes internationales de durabilité et la communication des entreprises chocolatières. Cette note examine comment l'agroforesterie s’est imposée dans l'agenda politique ivoirien. Adoptant une approche compréhensive et à partir d’une soixantaine d’entretiens et des documents politiques, elle analyse la manière dont la notion d’agroforesterie est mobilisée en Côte d’Ivoire, les instruments de sa promotion et les controverses qu’elle suscite. D’abord, ce travail montre que la mise à l’agenda de l’agroforesterie en Côte d’Ivoire se fait suivant des canaux pluriels. Différents instruments de promotion de l’agroforesterie se côtoient, tels que les normes de certification privée, la norme africaine régionale de durabilité pour le cacao, les paiements pour services environnementaux ou encore un dispositif national dit « Agro-Forêt », issu du nouveau Code forestier. Ensuite, malgré le consensus sur la promotion de l'agroforesterie, sa définition large permet à des acteurs aux intérêts divergents de s'approprier le concept. Ce travail met par ailleurs en évidence la pluralité des objectifs et des perspectives que recouvre la notion en Côte d’Ivoire. Il identifie ainsi des controverses concernant les critères du système agroforestier, sa finalité, la place des agriculteurs, l’échelle d’analyse et la temporalité à considérer. En définitive, cette note contribue à expliciter les traductions politiques plurielles d’une notion issue des sciences. Les liens complexes entre les recherches biophysiques et la pratique politique soulignent l'importance de prendre en compte cette interface pour une meilleure conception de l'agroforesterie et une transition efficace.
Promouvoir l’agroforesterie ? Les leçons de la Côte d’Ivoire
Authors: ZO-BI Irié Casimir , HÉRAULT Bruno 
Published: September 2023

L'émergence de l'agroforesterie en Côte d'Ivoire est devenue une priorité nationale. Le secteur agricole du pays génère 70 % des recettes d'exportation, emploie les deux tiers de la population active et contribue à un tiers du PIB. Cependant, ces performances économiques remarquables reposent sur une agriculture de rente qui se développe au détriment des forêts naturelles, entraînant l'un des taux de déforestation les plus alarmants au monde. Pour faire face à cette situation, l'État ivoirien promeut l'agroforesterie comme solution, en particulier dans le secteur du cacao. Cependant, une analyse fine de l’origine des arbres présents dans les champs suggère que l'agroforesterie en Côte d'Ivoire peut être divisée en deux catégories : l'agroforesterie de reforestation, qui permet de reconstituer le couvert forestier en associant progressivement des arbres aux cacaoyers, et l'agroforesterie de déforestation, qui dégrade et appauvrit la couverture forestière en convertissant les forêts naturelles en systèmes agroforestiers. Il est crucial de distinguer ces deux formes d'agroforesterie afin de développer des politiques qui encouragent la reforestation plutôt que la déforestation. Il est également nécessaire de mettre en place des indicateurs dynamiques qui permettent d’évaluer les trajectoires agroforestières des champs dans le temps et, ainsi, de favoriser un engagement à long terme des agriculteurs dans l'augmentation de la couverture forestière.
Bois et Forêts des Tropiques, numéros spéciaux et nouveau comité éditorial
Authors: Trébuchon Jean-François 
Published: September 2023

En 2022, deux grandes réunions consacrées à l’Agroforesterie se sont tenues : l’Euraf 2022, du 16 au 20 mai 2022, 6e Conférence européenne d’agroforesterie, en Italie ; et le 5e Congrès mondial de l'agroforesterie, du 17 au 20 juillet 2022 au Canada. Les organisateurs du Congrès mondial de l’Agroforesterie (Bissonnette et al.) ont joué le jeu en relayant l’appel à publier dans un numéro spécial de la revue Bois et Forêts des Tropiques. Quelques conférenciers présentaient des résultats de leurs travaux dans les zones méditerranéennes ou tropicales. Les auteurs ayant tenu les délais et les exigences de la revue voient leur engagement récompensé par la publication dans un numéro spécial qui s’étendra sur deux numéros Le nombre d’articles ayant été plus grand que la capacité d’un volume, quelques articles seront publiés dans le numéro suivant.
En 2023, la réunion IRG54 du Groupe international de recherche sur la protection du bois s’est tenue du 28 mai au 1er juin 2023 en Australie. Certains articles présentés lors de la session spéciale sur « Les bois tropicaux : chimie de la durabilité naturelle et conférée » seront évalués et publiés pour un prochain numéro spécial consacré à la durabilité des bois. La soumission des manuscrits approche de l’échéance et les auteurs peuvent toujours proposer leurs travaux.
Pendant ce temps, la revue Bois et Forêts des Tropiques a renouvelé en grande partie le comité éditorial en accueillant de nouvelles personnes sélectionnées pour accompagner la revue et y siéger en tant que membre. Elles représentent un échantillon de la diversité des recherches forestières appliquées qui sont publiées dans la revue. Nous les remercions de l’attention que chacune d’elles porte à la mission de la revue. Comme l’expose leur mission, nous les encourageons de nouveau à poursuivre l’amélioration des articles soumis et publiés, la proposition de manuscrits de leur entourage de doctorants et de chercheurs confirmés, et la suggestion de relecteurs internationaux potentiels. Le comité éditorial est constitué pour une durée de trois années.
Hemodynamic Disturbances Assess Cardiac Inefficiency in Repaired Fontan Patients: A 4D Flow Cardiovascular Magnetic Resonance Study
Authors: Hu Liwei , Zhao Xaiodan , Leng Shuang , Ouyang Rongzhen , Wang Qian , Sun Aimin , Liu Yiman , Zhong Liang , Zhong Yumin 
Published: September 2023

Objectives: The purposes of this study were to 1) analyze the disruption of intracardiac flow by flow components and kinetic energy (KE) parameters in single ventricle physiology patients and compare with controls; 2) investigate left ventricular diastolic dysfunction in terms of 4D flow parameters in repaired Fontan (rFontan) group; 3) compare intracardiac flow parameters in morphologic LV and RV rFontan patient groups.
Methods: Twenty-five rFontan patients (age: 10±3, M/F: 15/10) and fourteen controls (age: 10±2, M/F: 8/6) were prospectively recruited. All underwent cine and 4D flow cardiovascular magnetic resonance (CMR) on 3.0T scanner. Cardiac function and inter-ventricular mechanical dyssynchrony were analyzed using cine images. From 4D flow CMR, ventricular flow components were assessed: direct flow, retained inflow, delayed ejection flow and residual volume. Global and regional blood flow KE parameters, normalized to end-diastolic volume (EDV) were analyzed for functional single ventricle (FSV). Left ventricular (LV) diastolic dysfunction was assessed on echocardiography guidelines.
Results: In comparison of rFontan vs. controls, median FSV residual volume (28% vs. 23%, P= 0.034) were higher in rFontan; median FSV direct flow (32% vs. 40%, P=0.005) and delayed ejection flow (17% vs. 24%, P=0.024) were lower in rFontan. FSV KEiEDV parameters were all lower in rFontan (all P&lt;0.05). No significant diﬀerences were observed for flow components and KE parameters between patients with and without inter-ventricular dyssynchrony. FSV direct flow (AUC=0.76, Sensitivity=86%, Specificity=70%) was an independent predictor of LV diastolic dysfunction. Residual volume and E-wave KEiEDV were significantly different between morphologic RV and morphologic LV patient group.
Conclusions: The changed flow pattern and decreased KE may be hemodynamic disturbances and impaired ventricular filling in rFontan patients. Reduced direct flow is associated with LV diastolic dysfunction. Morphologic right ventricular subgroup is worse than morphologic left ventricular group in terms of the intracardiac hemodynamics.
A Negative Feedback Loop Between TET2 and Leptin in Adipocyte Regulates Body Weight
Authors: Deng Tuo , Zeng Qin , Song Jianfeng , Sun Xiaoxiao , Wang Dandan , Liao Xiyan , Ding Yujin , Hu Wanyu , Jiao Yayi , Mai Wuqian , Aini Wufuer , Wang Fanqi , Zhou Hui , Xie Limin , Mei Ying , Tang Yuan , Liu Wei 
Published: September 2023

Abstract
Ten-eleven translocation (TET) 2 is an enzyme that catalyzes DNA demethylation to regulate gene expression by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine, functioning as an essential epigenetic regulator in various biological processes. However, the regulation and function of TET2 in adipocytes during obesity are poorly understood. In this study, we demonstrate that leptin, a key adipokine in mammalian energy homeostasis regulation, suppresses adipocyte TET2 levels via JAK2-STAT3 signaling. Adipocyte Tet2 deficiency protects against high-fat diet-induced weight gain by reducing leptin levels and further improving leptin sensitivity. By interacting with C/EBPα, adipocyte TET2 increases the hydroxymethylcytosine levels of the leptin gene promoter, thereby promoting leptin gene expression. A decrease in adipose TET2 is associated with obesity-related hyperleptinemia in humans. Inhibition of TET2 suppresses the production of leptin in mature human adipocytes. Our findings support the existence of a negative feedback loop between TET2 and leptin in adipocytes and reveal a novel compensatory mechanism for the body to counteract the metabolic dysfunction caused by obesity.
Correlation between types of Ventricular Septal Defect and chromosomal abnormalities in Low-Risk Non-Invasive Prenatal Testing: A Retrospective Study
Authors: Zhao Xiaomin , Shen Yongmei , Kong Dexuan , Li Wen , Yao Liying , Li Shanshan , Chang Ying 
Published: September 2023

Abstract
Objective
The purpose of this study was to find the association between different types of ventricular septal defect (VSD) and chromosomal abnormalities in the low-risk setting of non-invasive prenatal testing (NIPT), as well as to analyze the prognosis of fetuses with different types of VSD.
Methods
Cases with prenatal diagnosis of fetal VSD by amniocentesis were collected from May 2017 to May 2022 at Tianjin Central Obstetrics and Gynecology Hospital. Patients with high risk of prenatal NIPT, including chromosomal number abnormalities, fragment deletions or duplications, and polymorphisms, were excluded from the study. The data collected included ultrasound classification of VSD, prenatal NIPT results, copy number variations (CNVs) results, and neonatal outcomes.
Results
This study examined 74 cases, consisting of 45 isolated VSDs (8 of which were muscular septal defects and 37 non-muscular septal defects) and 29 non-isolated VSDs (10 associated with intracardiac structural anomalies and 19 with extra-cardiac structural anomalies). The results showed that the prevalence of pathogenic CNV was lower in isolated VSDs than in non-isolated VSDs in a low-risk NIPT condition (χ2 = 9.344, P = 0.002). There was no significant disparity in the incidence of pathogenic CNV between VSDs with intracardiac and extra-cardiac structural anomalies (P = 0.541). Additionally, VSDs associated with intracardiac structural anomalies had the highest rate of surgical intervention.
Conclusions
When NIPT is low-risk, isolated VSD does not raise the likelihood of fetal chromosomal defects. However, when VSD is non-isolated and combined with either intra- or extracardiac structural issues, the possibility of pathogenic CNV is significantly higher, and thus, invasive prenatal diagnosis is suggested. Additionally, it was observed that isolated muscular septal defects usually does not require surgical treatment, which provides a useful foundation for prenatal counseling regarding fetal VSD.
Environmental factors associated with incidence of developmental dysplasia of the hip
Authors: Huang Yu-Yi , Lee Wei-Chun , Chang Chia-Hsieh , Yang Wen-E , Kao Hsuan-Kai 
Published: September 2023

Abstract
Background
Established risk factors for DDH include female sex, breech presentation, family history, congenital malformations, oligohydramnios, and maternal hyperthyroidism. However, evidence for environmental factors that may contribute to DDH is limited and inconsistent.
Methods
A review of medical literature from 1956 to 2023 was conducted to collect data on environmental factors, including latitude, longitude, average yearly precipitation, average yearly temperature, minimum monthly temperature, and maximum monthly temperature, from all institutions that published articles on DDH. Univariate linear regression analysis was used to examine the correlation between environmental factors and DDH incidence, while multiple regression analysis was conducted to identify significant risk factors for DDH incidence.
Results
Data from a total of 93 unique manuscripts were analyzed, revealing a significant negative correlation between DDH incidence and temperature, including average yearly temperature (r = -0.27, p = 0.008), minimum monthly temperature (r = -0.28, p = 0.006), and maximum monthly temperature (r = -0.23, p = 0.029). Additionally, there was a significant positive correlation between DDH incidence and latitude (r = 0.27, p = 0.009), and a significant negative correlation between DDH incidence and average yearly precipitation (r = -0.29, p = 0.004). In the final multiple regression analysis, temperature, including average yearly temperature, minimum monthly temperature, and maximum monthly temperature, were identified as significant risk factors for DDH incidence.
Conclusion
The study findings suggest that temperature is the most significant predictor of DDH incidence, highlighting the potential impact of colder weather on DDH development in infants.
Bioinformatics Revealed Biomarkers For Diagnosis In Kidney Stones
Authors: He Ziqi , Song Chao , Dong Caitao , Wang Zhong , Li Sheng 
Published: September 2023

Abstract
One of the most prevalent urinary illnesses is kidney stone formation, often known as nephrolithiasis. The precise processes of kidney stone remain poorly known after substantial investigation. In order to successfully prevent and cure stone formation and recurrence, additional research into the pathophysiology of stone formation is of paramount importance. Ferroptosis is linked to a variety of renal diseases and is a critical factor in the death of cells. However, little is known about how ferroptosis-related genes (FRGs) contribute to the development of kidney stones. The Ferroptosis Database and the Gene Expression Omnibus (GEO) database provided us with information on kidney stones and FRGs, respectively (FerrDb). Eight DE-FRGs related to kidney stones were found in total, and they were all closely related to immune response and autophagy management. Following this, among the 8 DE-FRGs, LASSO and SVM-RFE algorithms chose FZD7, STK11, SUV39H1, and LCN2 as marker genes with suitable diagnostic capabilities. These marker genes may be involved in the control of the PPAR signaling pathway, mTOR signaling system, and fatty acid production of kidney stones, according to the functional enrichment analysis that followed. Additionally, 24 drugs that target two marker genes have been found. Despite this, the ceRNA networks have gained that the regulatory relationship between marker genes is rather complex. Additionally, the findings of the CIBERSORT investigation indicated that FZD7 and SUV39H1 may be linked to variations in the immune milieu of people who have kidney stones. We developed a diagnostic tool and provided information on the development of kidney stones. In order to confirm its diagnostic applicability for kidney stones, more studies are needed before it may be used in clinical practice.
Subtalar titanium screw arthroereisis for the treatment of the symptomatic pediatric flatfoot
Authors: Szesz Anna , Małecki Krzysztof , Sibiński Marcin , Niedzielski Kryspin R. 
Published: September 2023

Abstract
Background. Idiopathic flexible flatfoot in children is a common condition which most frequently improves with age and remains asymptomatic. In some cases, the condition is more severe, and may cause mechanical impairment or pain. The aim of the study was to perform a prospective clinical, radiological, podoscopic and pedobarographic assessment (static and dynamic) of subtalar titanium screw arthroereisis for the treatment of symptomatic, idiopathic, flexible flatfoot. Methods. A prospective, consecutive, non-controlled, cohort, clinical follow-up study was performed. In total, 30 patients (41 feet), mean age 10 (6 to 16 years), were evaluated. Clinical and standing radiological assessments, static and dynamic pedobarography, as well as podoscopy, were performed before surgery and at final follow-up. Results. Significant improvements were found for heel valgus angle, radiographic parameters (lateral and dorso-planar talo-1st metatarsal angle, calcaneal inclination angle, talar declination angle, longitudinal arch angle) and podoscopic parameters (Clark’s angle, Staheli’s arch index and Chippaux-Smirak index). The dynamic pedobarography identified significant increases in lateral loading, forefoot contact phase and double support / swing phase, together with reduced medial loading. Static pedobarography identified significant increases in lateral midfoot area and loading, and a decrease in medial forefoot loading. Four patients reported persistent pain in the sinus tarsi region (six feet) and in one case the implant was replaced for a larger one due to undercorrection. No overcorrections or infection complications were noted in our study group. Conclusions. Subtalar arthroereisis is a minimally-invasive and effective method of surgical treatment of symptomatic, idiopathic, flexible flatfoot with low complication rate with good clinical results.
Increasing the ratio of red to blue light as supplemental light improves growth, photosynthesis, and yield of cut roses
Authors: Davarzani Maryam , Aliniaeifard Sasan , Mehrjerdi Mahboobeh Zare , Roozban Mahmoud Reza , Saeedi Seyyed Arash 
Published: September 2023

Abstract
During the seasons with limited light intensity, reductions in growth, yield and quality are challenging issues for commercial cut rose production in greenhouses. Using artificial supplemental light is recommended for maintaining commercial production in regions with limited light intensity. Nowadays, replacement of traditional lighting sources with LEDs attracted lots of attentions. Since red (R) and blue (B) light spectra present the important wavelengths for the photosynthesis and growth, in the present study different ratios of supplemental R and B lights including 90% R: B 10% (R90B10), 80% R: 20% B (R80B20), 70% R: 30% B (R70B30) with an intensity of 150 µmol m− 2 s− 1 together with natural light and without supplemental light (control) were applied on two commercial rose cultivars. According to the obtained results, supplemental light improved growth, carbohydrate levels, photosynthesis capacity, and yield when compared to the control. R90B10 in both cultivars reduced the time required for flowering compared to the control treatment. The highest number of harvested flower stems was obtained by R90B10 and R80B20 in both cultivars. Chlorophyll and carotenoid levels were the highest under control and higher ratio of B light, while carbohydrate and anthocyanin contents increased by having high ratio of R light in the supplemental light. Analysis of chlorophyll fluorescence were indicative of better photosynthetic performance under high ratio of R light in the supplemental light. In conclusion, R90B10 light regime is recommended as suitable supplemental light recipie to improve growth and photosynthesis, to accelerate flowering, and to improve the yield and quality of cut roses.