bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lattice cohomology and q-series invariants of 3-manifolds
Authors: Akhmechet Rostislav , Johnson Peter K. , Krushkal Vyacheslav 
Published: February 2023

Abstract
In this paper, an invariant is introduced for negative definite plumbed 3-manifolds equipped with a spin

c

{{}^{c}}

-structure. It unifies and extends two theories with rather different origins and structures. One theory is lattice cohomology, motivated by the study of normal surface singularities, known to be isomorphic to the Heegaard Floer homology for certain classes of plumbed 3-manifolds. Another specialization gives BPS q-series which satisfy some remarkable modularity properties and recover

SU
⁢

(
2
)

{{\rm SU}(2)}

quantum invariants of 3-manifolds at roots of unity.
In particular, our work gives rise to a 2-variable refinement of the

Z
^

{\widehat{Z}}

-invariant.
Nonmeasurable products of absolutely negligible sets in uncountable solvable groups
Authors: Kharazishvili Alexander 
Published: February 2023

Abstract
It is shown that, for any uncountable solvable group

(
G
,
⋅
)

{(G,\cdot\,)}

and any nonzero σ-finite left G-quasi-invariant measure μ on G,
there exist two G-absolutely negligible subsets A and B of G such
that the product

A
⋅
B

{A\cdot B}

is not measurable with respect to μ.
The triharmonic equation on the Heisenberg group
Authors: Izadjoo Majid , Akbari Mojgan 
Published: February 2023

Abstract
Consider the equation

{

-

Δ
H
3

⁢
u

=

f
⁢

(
ξ
,
u
,

∇
H

⁡
u

,

∇
H
2

⁡
u

,

∇
H
3

⁡
u

,

∇
H
4

⁡
u

,

∇
H
5

⁡
u

)

in
⁢
Ω

,

u

>
0

in
⁢
Ω

,

u

=

∂

∂
⁡
ν

⁢

(

∇
H
2

⁡
u

)

=

∂

∂
⁡
ν

⁢

(

∇
H
3

⁡
u

)

=
0

on
⁢

∂
⁡
Ω

,

\left\{\begin{aligned} \displaystyle{}{-}\Delta_{H}^{3}u&\displaystyle=f(\xi,u%
,\nabla_{H}u,\nabla_{H}^{2}u,\nabla_{H}^{3}u,\nabla_{H}^{4}u,\nabla_{H}^{5}u)&%
&\displaystyle\phantom{}\text{in }\Omega,\\
\displaystyle u&\displaystyle>0&&\displaystyle\phantom{}\text{in }\Omega,\\
\displaystyle u&\displaystyle=\dfrac{\partial}{\partial\nu}(\nabla_{H}^{2}u)=%
\dfrac{\partial}{\partial\nu}(\nabla_{H}^{3}u)=0&&\displaystyle\phantom{}\text%
{on }\partial\Omega,\end{aligned}\right.

where Ω is a domain of the finite-dimensional space

ℍ
n

{\mathbb{H}^{n}}

and f is a positive and bounded function. We prove the existence of a solution for the above equation. In addition, we prove the uniqueness and the cylindrical symmetry of the solution.
Membrane damage and repair: a thin line between life and death
Authors: Barisch Caroline , Holthuis Joost C. M. , Cosentino Katia 
Published: February 2023

Abstract
Bilayered membranes separate cells from their surroundings and form boundaries between intracellular organelles and the cytosol. Gated transport of solutes across membranes enables cells to establish vital ion gradients and a sophisticated metabolic network. However, an advanced compartmentalization of biochemical reactions makes cells also particularly vulnerable to membrane damage inflicted by pathogens, chemicals, inflammatory responses or mechanical stress. To avoid potentially lethal consequences of membrane injuries, cells continuously monitor the structural integrity of their membranes and readily activate appropriate pathways to plug, patch, engulf or shed the damaged membrane area. Here, we review recent insights into the cellular mechanisms that underly an effective maintenance of membrane integrity. We discuss how cells respond to membrane lesions caused by bacterial toxins and endogenous pore-forming proteins, with a primary focus on the intimate crosstalk between membrane proteins and lipids during wound formation, detection and elimination. We also discuss how a delicate balance between membrane damage and repair determines cell fate upon bacterial infection or activation of pro-inflammatory cell death pathways.
The Dark Side of Insurance
Authors: Avraham Ronen , Porat Ariel 
Published: February 2023

Abstract
When insurance works properly it provides insureds with optimal incentives to prevent losses, alongside coverage for losses that could not be prevented efficiently. But insurance has an overlooked dark side to it as well. Insurers employ various tactics to shift losses to their insureds or to their victims in order to minimize their own costs instead of reducing their insureds’ losses. Worse, insurers might also act to increase or maintain long term risks, ensuring the future of the insurance business that can’t exist without risks. We focus on the incentives of insurers to engage in anti-competitive practices and trigger harmful behaviors of their insureds or third parties, in order to increase demand for insurance coverage. Policymakers should be aware and critical of insurers’ perverse incentives that counteract the interests of the insureds and society.
Retinal Dysfunction in a Mouse Model of HCN1 Genetic Epilepsy
Authors: Zhao Da , Pinares-Garcia Paulo , McKenzie Chaseley E. , Bleakley Lauren E. , Forster Ian C. , Wong Vickie H.Y. , Nguyen Christine T.O. , Scheffer Ingrid E. , Reid Christopher A. , Bui Bang V. 
Published: February 2023

Pathogenic variants inHCN1are associated with a range of epilepsy syndromes including a developmental and epileptic encephalopathy. The recurrentde novo HCN1pathogenic variant (M305L) results in a cation leak, allowing the flux of excitatory ions at potentials where the wild-type channels are closed. The Hcn1M294Lmouse recapitulates patient seizure and behavioral phenotypes. As HCN1 channels are highly expressed in rod and cone photoreceptor inner segments, where they shape the light response, mutated channels are likely to impact visual function. Electroretinogram (ERG) recordings from male and female mice Hcn1M294Lmice revealed a significant decrease in the photoreceptor sensitivity to light, as well as attenuated bipolar cell (P2) and retinal ganglion cell responses. Hcn1M294Lmice also showed attenuated ERG responses to flickering lights. ERG abnormalities are consistent with the response recorded from a single female human subject. There was no impact of the variant on the structure or expression of the Hcn1 protein in the retina.In silicomodeling of photoreceptors revealed that the mutated HCN1 channel dramatically reduced light-induced hyperpolarization, resulting in more Ca2+flux during the response when compared with the wild-type situation. We propose that the light-induced change in glutamate release from photoreceptors during a stimulus will be diminished, significantly blunting the dynamic range of this response. Our data highlight the importance of HCN1 channels to retinal function and suggest that patients withHCN1pathogenic variants are likely to have a dramatically reduced sensitivity to light and a limited ability to process temporal information.SIGNIFICANCE STATEMENTPathogenic variants in HCN1 are emerging as an important cause of catastrophic epilepsy. HCN1 channels are ubiquitously expressed throughout the body, including the retina. Electroretinogram recordings from a mouse model ofHCN1genetic epilepsy showed a marked decrease in the photoreceptor sensitivity to light and a reduced ability to respond to high rates of light flicker. No morphologic deficits were noted. Simulation data suggest that the mutated HCN1 channel blunts light-induced hyperpolarization and consequently limits the dynamic range of this response. Our results provide insights into the role HCN1 channels play in retinal function as well as highlighting the need to consider retinal dysfunction in disease caused byHCN1variants. The characteristic changes in the electroretinogram open the possibility of using this tool as a biomarker for this HCN1 epilepsy variant and to facilitate development of treatments.
A Discourse of Capital Punishment in the Islamic Law and Human Rights Law
Authors: Saputro Muhammad Eko , Febriansyah Andhika , Putri Faradisya Diandra 
Published: February 2023

The death penalty for convicts is an age-old subject to a lot of criticism from various quarters. The implementation of the death penalty is considered inconsistent with the principles of human rights which are principles of international law where countries cannot refuse because of common alignments, namely the right to life. The punishment of m ati raises pros and cons in Indonesian society, some agree with this punishment because the death penalty intends to protect the public interest and not a few oppose it, they argue that the death penalty is contrary to human rights principles. This fact encourages the author to examine the implementation of the death penalty based on human rights and Islamic law, this is because the majority of Indonesians are adherents of the Islamic religion and also because the implementation of the death penalty is still carried out in Indonesia in certain crime cases. To examine this conflict, the author uses a normative juridical method with the conclusion that the death penalty is contrary to human rights because it eliminates the right to life for a person, but the implementation of the death penalty can be justified if the implementation of the death penalty is carried out in order to protect human rights and is also imposed on convicts who commit crimes beyond the limits stipulated in the legislation.
Щодо повоєнного відродження України
Authors: Лібанова Елла Марленівна 
Published: February 2023

У доповіді представлено підготовлену Відділенням економіки НАН України візію повоєнного відродження України, яка передбачає формування модерного демократичного суспільства зі стійкою до ризиків людиноцентричною економікою. Програми відновлення та повоєнного розвитку України мають ґрунтуватися на чіткому баченні власного майбутнього і спиратися передусім на національні інтереси. Основою повоєнного відродження України має стати новий суспільний договір, спрямований на максимально справедливий розподіл результатів економічного зростання, зниження нерівності і бідності населення, досягнення східноєвропейських параметрів якості життя.
Цитування: Лібанова Е.М. Щодо повоєнного відродження України. Вісник НАН України. 2023. № 2. С. 55—61. https://doi.org/10.15407/visn2023.02.055
Biological functionality and characteristics of Jerusalem artichoke (Helianthus tuberosus L.) tuber extracts
Authors: Afoakwah N.A. , Zhao Y. , Dong Y. 
Published: February 2023

AbstractJerusalem artichoke tuber extracts (JAE) bioactivity including anticancer, antimicrobial, and digestion-inhibiting properties were investigated. The findings showed that the extracts were able to inhibit cancer growth in the HT-29 colon cancer cell line (HT-29 cc cell line) in a dose-dependent form. The suppression of cell proliferation rose to about 78.05 ± 3.9 percent at a dose of 250 μg mL−1. The Annexin V assay showed dose-dependent DNA fragmentation and detected late apoptotic induction in the HT-29 cc cell line. Depending on the concentration, the extract was able to stop the cell cycle in the HT-29 cc cell line at the G1 phase. Also, JAE prevented the HT-29 cc cell line growth, which resulted in programmed cell death. Additionally, the extracts are potential antibacterial agents and may inhibit lipase and α-amylase.
Integrasi Pelayanan Teman Bus Terhadap Kawasan Strategis Pariwisata Nasional di Bali
Authors: Ginting Verina Dwiyolanda , Putra I Kadek Krisnanda , Maharani Ni Putu Anistia , Kusuma Rizal Arzi Fajar , Dwipayana Arif Devi 
Published: February 2023

The transportation service integration system aims to facilitate transportation users in carrying out activities. One factor that determines the integration of transportation services is the route. "Teman Bus" is here to facilitate the movement of tourists in Bali which is the implementation of the Ministry of Transportation program. The research explains and provides an overview related to the Teman Bus service as a program of the Ministry of Transportation in an effort to realize a transportation system with a buy-the-service concept in terms of route or route service aspects, facilities, and community satisfaction. Data analysis was done using questionnaires which are distributed to the public using the Teman Bus service. The results of the study show that the most perceived obstacle from these three aspects is the lack of integration of the Teman Bus service route to the national tourism strategic area in Bali. This is the cause of the public interest decline in the Teman Bus service. Evaluation of Teman Bus services is that in the future they can add or improve routes so that they can provide convenience to passengers, especially local and foreign people, in moving from one tourist location to another.
ABSTRAK
Sistem integrasi layanan transportasi bertujuan untuk memudahkan pengguna transportasi dalam melakukan kegiatan. Salah satu faktor yang menentukan integrasi layanan transportasi adalah rute. “Teman Bus” hadir untuk memudahkan pergerakan wisatawan di Bali yang merupakan implementasi dari program Kementerian Perhubungan. Tujuan penelitian menjelaskan dan memberikan gambaran terkait dengan layanan Teman Bus sebagai program Kementerian Perhubungan dalam upaya mewujudkan sistem transportasi yang berkonsep buy the service dilihat dari aspek pelayanan jalur atau rute, fasilitas dan kepuasan masyarakat. Teknik analisis data yang digunakan adalah analisis secara deskriptif menggunakan kuesioner untuk melihat pendapat responden terkait dengan layanan Teman Bus. Hasil penelitian menunjukkan hambatan yang paling dirasakan dari ketiga variabel tersebut adalah kurang terintegrasinya rute pelayanan Teman Bus terhadap kawasan strategis pariwisata nasional di Bali. Hal ini menjadi penyebab minat masyarakat terhadap layanan Teman Bus menurun. Kesimpulan dari penelitian ini adalah Teman Bus melakukan evaluasi untuk dapat menambah atau memperbaiki rute sehingga memberikan kemudahan kepada penumpang, terutama masyarakat lokal maupun asing dalam melakukan perpindahan dari satu lokasi wisata ke lokasi wisata lainnya.
An Interrupted Time Series Analysis Measuring the Impact of Research and Education on Clinical Practice
Authors: Maletis Gregory B. , Prentice Heather A. , Wyatt Ronald W.B. , Paxton Elizabeth W. , Funahashi Tadashi T. 
Published: February 2023

Background:We sought to evaluate whether allograft utilization for primary anterior cruciate ligament reconstruction (ACLR) within our health-care system changed following the implementation of an allograft reduction intervention and whether revision rates within the health-care system changed following the initiation of the intervention.Methods:We conducted an interrupted time series study using data from Kaiser Permanente’s ACL Reconstruction Registry. In our study, we identified 11,808 patients who were ≤21 years of age and underwent primary ACLR from January 1, 2007, through December 31, 2017. The pre-intervention period (15 quarters) was January 1, 2007, through September 30, 2010, and the post-intervention period (29 quarters) was October 1, 2010, through December 31, 2017. Poisson regression was used to evaluate trends over time in 2-year revision rates according to the quarter in which the primary ACLR was performed.Results:Allograft utilization increased pre-intervention from 21.0% in 2007 Q1 to 24.8% in 2010 Q3. Utilization decreased post-intervention from 29.7% in 2010 Q4 to 2.4% in 2017 Q4. The quarterly 2-year revision rate increased from 3.0 to 7.4 revisions per 100 ACLRs pre-intervention and decreased to 4.1 revisions per 100 ACLRs by the end of the post-intervention period. Poisson regression found an increasing 2-year revision rate over time pre-intervention (rate ratio [RR], 1.03 [95% confidence interval (CI), 1.00 to 1.06] per quarter) and a decreasing rate over time post-intervention (RR, 0.96 [95% CI, 0.92 to 0.99]).Conclusions:In our health-care system, we saw a decrease in allograft utilization following the implementation of an allograft reduction program. During the same period, a decrease in the ACLR revision rate was observed.Level of Evidence:TherapeuticLevel IV. See Instructions for Authors for a complete description of levels of evidence.
Final Amalgamation Processes of the Southern Altaids: Insights from the Triassic Houhongquan Ophiolitic Mélange in the Beishan Orogen (NW China)
Authors: Mao Qigui , Xiao Wenjiao , Ao Songjian , Song Dongfang , Sang Miao , Tan Zhou , Wang Hao , Li Rui , Wang Meng 
Published: February 2023

AbstractThe Permian–Triassic tectonic setting is still controversial in the southern Altaids. The Beishan orogen is an ideal region to address the final tectonic of the Altaids. These systematic mapping, geochemistry, and geochronology studies on the Houhongquan ophiolitic mélange in the south Beishan are conducted to address this issue. New mapping reveals that the Houhongquan ophiolitic mélange consists of blocks of gabbro, basalt, chert, granite, and strongly deformed and cleaved sandstone in the southern Beishan. The studies reveal that the mafic fragments are relics of normal-mid-ocean ridge (N-MOR) and suprasubduction zone (SSZ) types of oceanic lithosphere. The four sandstone matrix samples yield the maximum depositional ages of 222±5 Ma, 233.8±2.3 Ma, 263.4±2.5 Ma, and 263.5±2.8 Ma, respectively, indicating that the youngest sandstones were tectonic emplaced in the Houhongquan ophiolitic mélange after ca. 222 Ma. The sandstone matrices display two types of age spectra. Early Permian sandstones have a single Devonian to Early Permian peak age patterns, indicating the existence of an independent Permian intraoceanic arc. In contrast, Late Triassic sandstones have multiple peaks with some Precambrian zircons, suggesting that they were sourced from a continental arc. Accordingly, we consider that the Houhongquan ophiolitic mélange tectonic was emplaced in the intraoceanic island arc during the Middle Permian and docked to a continental margin arc during the Late Triassic. Thus, we argue that the terminal amalgamation timing of the southern Altaids was probably during ca. 222-217 Ma.
PDE4DIP contributes to colorectal cancer growth and chemoresistance through modulation of the NF1/RAS signaling axis
Authors: Pan Rulu , Dai Juji , Liang Weicheng , Wang Hongxiao , Ye Lin , Ye Siqi , Lin Ziqi , Huang Shishun , Xiong Yan , Zhang Li , Lu Liting , Wang Ouchen , Shen Xian , Liao Wanqin , Lu Xincheng 
Published: February 2023

Abstract
Phosphodiesterase 4D interacting protein (PDE4DIP) is a centrosome/Golgi protein associated with cyclic nucleotide phosphodiesterases. PDE4DIP is commonly mutated in human cancers, and its alteration in mice leads to a predisposition to intestinal cancer. However, the biological function of PDE4DIP in human cancer remains obscure. Here, we report for the first time the oncogenic role of PDE4DIP in colorectal cancer (CRC) growth and adaptive MEK inhibitor (MEKi) resistance. We show that the expression of PDE4DIP is upregulated in CRC tissues and associated with the clinical characteristics and poor prognosis of CRC patients. Knockdown of PDE4DIP impairs the growth of KRAS-mutant CRC cells by inhibiting the core RAS signaling pathway. PDE4DIP plays an essential role in the full activation of oncogenic RAS/ERK signaling by suppressing the expression of the RAS GTPase-activating protein (RasGAP) neurofibromin (NF1). Mechanistically, PDE4DIP promotes the recruitment of PLCγ/PKCε to the Golgi apparatus, leading to constitutive activation of PKCε, which triggers the degradation of NF1. Upregulation of PDE4DIP results in adaptive MEKi resistance in KRAS-mutant CRC by reactivating the RAS/ERK pathway. Our work reveals a novel functional link between PDE4DIP and NF1/RAS signal transduction and suggests that targeting PDE4DIP is a promising therapeutic strategy for KRAS-mutant CRC.
A Novel Multi-Criterion Decision-Making Strategy Using TOPSIS Under Non-Linear Diophantine Fuzzy Numbers for the COVID-19 Problem
Authors: Ahmad Sohail , Bibi Batool , Jun Wang 
Published: February 2023

Abstract
This study aims to introduce a novel Non-Linear Diophantine Fuzzy Multi-Criterion Decision-Making Model for
COVID-19 diagnosis and control. The study is organised into three sections to encourage individuals and to
develop an appropriate strategy for emergency decision-making circumstances. First, we propose a generalizations
of Pythagorean fuzzy sets, q-rung orthopair fuzzy sets, and linear Diophantine fuzzy set, called Non-linear
Diophantine fuzzy set (Non-LDFS) and discussed their important properties. Moreover, mathematical criteria for
Non-LDFSs are established based on certain operating laws. In the second part of the study, we propose a set of
Non-LDF averaging and geometric aggregation operators for aggregating expert judgments based on TOPSIS
techniques. In final part, the newly defined Non-LDF Topsis Method is used to solve a medical diagnosis challenge
for the COVID-19 virus, and the findings are reported. To accomplish this, we developed an enhanced
”multi-criteria decision-making” (MCDM) technique that should be capable of evaluating and selecting the best
alternative choice of COVID-19 based on five criteria. A comparative analysis is also performed for the novel
Non-LDF Topsis, and the prospects of the designed research are addressed.
Day- Ahead Economic Load Dispatch Operation Based on Forecasted Electricity Demand Uncertainty for Enhanced Energy Management
Authors: Sahay Kishan Bhushan , Singh Mukhtiar 
Published: February 2023

Abstract
In present scenario, forecasting electricity load, price, wind farm power & solar PV power etc. accurately plays important role while any decision making for planning, operation, and control for the economic & efficient operation of the power system. An Economic Load Dispatch Operation is required for economic & efficient operation of the power plant. It is a used for scheduling the output of the connected generating unit of a plant to fulfil the electricity load requirement at minimum cost by satisfying all inequality and equality constraints. In this paper, firstly 24 hour ahead electricity load has been forecasted on hourly basis. Secondly, this forecasted load is used for predicting day-ahead economic load dispatch operation by using particle swarm optimization. The results show the optimum operating cost.
Walking difficulties and brainstem dysfunction: a case report of adult onset Leigh syndrome
Authors: Cipriano Elia , Vecchio Domizia , Mazzini Letizia , Strigaro Gionata , Piga Daniela , Sciacco Monica , Comi Giacomo , Genovese Egidio , Cantello Roberto 
Published: February 2023

Abstract
Introduction: Leigh syndrome a progressive, lethal, mitochondrial disease.
Case Presentation: We report the case of an adult man in his 40s presenting to the Emergency Department showing: dysarthria, oculomotor limitations for downgaze and convergence, mild right hemiparesis with Babinski sign and absent lower limb tendon reflexes. He revealed about walking difficulties since the age of 20-25. Family history was unremarkable. A brain magnetic resonance showed diffuse white matter lesions involving the area around the third ventricle, the medulla oblongata, and the bilateral caudate and putamen without contrast enhancement.
Conclusions: Polymerase-chain-reaction amplification of the mitochondrial genes, followed by direct sequencing, found a 10191T>C variant related to Leigh syndrome. Leigh syndrome mostly occurring mostly in childhood, there are only other 8 late-onset cases described sharing the same pathogenic variant. LS or subacute necrotizing encephalomyelopathy is a progressive, lethal, mitochondrial disease mostly occurring in childhood. Only other 8 late-onset cases share the same pathogenic variant, i.e. 10191T>C.