bluuebunny/crossref_metadata_2025_split huggingface dataset:
The spillover effects of online tourism platforms on sustainable development
Authors: Chen Yuting , Zhang Nan , Cheng Xiaokang 
Published: May 2023

AbstractIn recent years, the proliferation of self‐established and third‐party online tourism platforms has impacted the visitor economy and social welfare sustainably. Tourism enterprises face the key decision of whether to join third‐party platforms or sell tourism services/products directly to consumers. Some researchers have addressed issues about online tourism platforms, but none analyse the internal mechanism and operational management, or the impact of the online tourism platform on sustainable economic growth and social welfare. To fill this gap, we establish an analytical model to explore the optimal tourism marketing and operational management of online tourism platforms for non‐profit tourist attractions and for‐profit tourism enterprises, which can help guide the decisions of managers. We construct a game‐theoretical model in which competing tourism attractions can choose only solo or dual online tourism platform promotion. When competition on a third‐party platform is intense, for‐profit tourism enterprises benefit from dual platforms. We further illustrate that with high competition, non‐profit tourist attractions provide higher social welfare when offering tourism products/services on both self‐established and third‐party tourism channels. However, with lower competition, third‐party tourism platforms harm social welfare if the tourism service/product quality is extremely high or low. Under a decentralised structure, we find that related tourism enterprises prefer to follow and collaborate with their tourist attractions' channel selection when competition in the third‐party platform is not fierce. This result indicates that a third‐party tourism platform improves the visitor economy and social welfare if the tourist attraction collaborates with its tourism‐related enterprises through the online tourism platform.
Destroy All Humans: The Dematerialisation of the Designer in an Age of Automation and its Impact on Graphic Design—A Literature Review
Authors: Matthews Benjamin , Shannon Barrie , Roxburgh Mark 
Published: May 2023

AbstractDigital automation is on the rise in a diverse range of industries. The technologies employed here often make use of artificial intelligence (AI) and its common form, machine learning (ML) to augment or replace the work completed by human agents. The recent emergence of a variety of design automation platforms inspired the authors to undertake a review of the research literature on the impact of Automation, AI and ML on visual communication, and its subset practice of graphic design, with a view to understanding the implications for the education of practitioners entering that specific field. This review discovered that there was relatively little research published on the topic but what did exist noted that graphic design as we have known it has an uncertain future. Furthermore, the scant literature argued for a shift in educational and professional focus away from the aesthetic and technical skills required to design visual modes of communication and towards a deeper engagement with the softer, more human skills associated with negotiation, facilitation and judgement. The paucity of literature on this topic suggests to the authors that visual communication design education and the industry are poorly prepared for the impact of automation, AI and ML on them.
Artificial intelligence on the advance to enhance educational assessment: Scientific clickbait or genuine gamechanger?
Authors: Zehner Fabian , Hahnel Carolin 
Published: May 2023

AbstractContributions in the Special IssueThe special issue assembles papers centring around log data analysis, natural language processing, and machine learning used to advance educational assessment. They demonstrate how semi‐ and unstructured data such as log and text data can, despite their challenging nature, be handled appropriately to benefit educational assessment. In this editorial, we contextualize the special issue's contributions within the diverse field of modern technology‐based assessments.Reflection on TerminologyMoreover, we raise concerns about nowadays' use of the term artificial intelligence (AI) in scientific communication. While the contribution of AI to scientific progress is indisputable, the mere use of methods that have evolved within AI research does not necessarily render tools or studies AI‐related. We argue that academics have the social responsibility to adopt accurate terminology, given it is integral to scientific rigour and proper scientific communication.ImplicationsIn view of the inflationary use of the term AI in science, we propose a scheme to locate one's research in the field by focusing on (1) the type of data, (2) the processing involved, and (3) the output of a study and the actions derived from it, which are situated within the (4) scope of a study.
Using online learner trace data to understand the cohesion of teams in higher education
Authors: Zamecnik Andrew , Kovanovíc Vitomir , Joksimovíc Srécko , Grossmann Georg , Ladjal Djazia , Marshall Ruth , Pardo Abelardo 
Published: May 2023

AbstractBackgroundMaintaining cohesion is critical for teams to achieve shared goals and performance outcomes within a work‐integrated learning (WIL) environment. Cohesion is an emergent state that develops over time, representing the synchrony of different behavioural interactions. Cohesive teams will exhibit such phenomena by their temporal coordination of micro‐level relations.ObjectivesThe primary aim of this study is to examine the cohesion of teams in learning environments using a learning analytics approach.MethodThis study examines teams from higher education who participate in a WIL environment platform working in teams to develop their collaborative problem‐solving skills. Here we show that temporal network motifs can be used as a proxy to measure cohesion.Results and ConclusionsWe illustrate three clusters represented by team learning behaviours and found that each cluster has distinctive interactions with learning resources, performance outcomes, temporal network motif group characteristics and emergence over time using learning analytics.ImplicationsApplying temporal motifs as an analytics‐based measure of cohesion is a starting point for understanding how cohesion develops over time without relying on surveys. We anticipate that the same approaches can be applied in most learning management systems containing trace data of teams and their interactions with learning resources to understand cohesion.
Hatch date and early growth of juvenile Japanese jack mackerel Trachurus japonicus caught in the Uwa Sea
Authors: Hashida Daisuke , Tomiyama Takeshi 
Published: May 2023

AbstractDevelopment and growth rate variations during early life are important for understanding the mechanisms of recruitment dynamics. We examined the larval growth rate and age at the onset of metamorphosis (dm) of juvenile Japanese jack mackerel recruited to a population in the Uwa Sea, Japan. Otolith microstructure analyses revealed that the hatch date of juveniles ranged from February to April in 2011–2015, and that their dm were 25.5–30.5 days and mean growth rates at the larval stage (GL) were 0.30–0.34 mm day−1. Among dm and GL, dm showed significant negative correlations with juvenile abundance. Moreover, the hatch date did not coincide with the spawning period of this species in the Uwa Sea, and the hatch date and mean growth rate at the larval stage were comparable to those of Japanese jack mackerel juveniles sampled in the East China Sea (ECS). These findings suggest that most juvenile Japanese jack mackerel originated in other waters, including the ECS, and that larval stage duration influenced their recruitment abundance in the Uwa Sea.
Identification and genetic characterization of Saprolegnia parasitica, isolated from farmed and wild fish in Finland
Authors: Engblom Christine , Landor Lotta , Sjöqvist Conny , Korkea‐aho Tiina , Viljamaa‐Dirks Satu , Paulin Lars , Wiklund Tom 
Published: May 2023

AbstractOomycete infections in farmed fish are one of the most significant disease issues in salmonid aquaculture worldwide. In the present study, Saprolegnia spp. in different farmed fish species in Finland were identified, and the molecular epidemiology of especially Saprolegnia parasitica was examined. We analysed tissue samples from suspected oomycete‐infected salmonids of different life stages from a number of fish farms, as well as three wild salmonids. From collected oomycete isolates, the ITS1, 5.8S and ITS2 genomic regions were amplified, analysed phylogenetically and compared with corresponding sequences deposited in GenBank. Of the sequenced isolates, 91% were identified as S. parasitica. Isolates of yolk sac fry were identified as different Saprolegnia spp. Among the isolates from rainbow trout eggs Saprolegnia diclina dominated. In order to determine potential dominating clones among the S. parasitica, isolates were analysed using Multi Locus Sequence Typing (MLST). The results showed that one main clone contained the majority of the isolates. The MLST analysis showed four main sequence types (ST1–ST4) and 13 unique STs. This suggests that the Saprolegnia infections in farmed fish in Finland are not caused by different strains originating in the farm environment. Instead, one main clone of S. parasitica is present in Finnish fish farms.
The role of loneliness on hearing ability and dementia: A novel mediation approach
Authors: Hackett Ruth A. , Vo Tat Thang , Vansteelandt Stijn , Davies‐Kershaw Hilary 
Published: May 2023

AbstractBackgroundTo determine the potential mediating role of loneliness in the relationship between hearing ability and dementia.MethodsDesign: Longitudinal observational study. Setting: English Longitudinal Study of Ageing (ELSA). Participants: Individuals aged 50 and older (N = 4232). Measurements: Self‐reported hearing ability and loneliness were assessed from Wave 2 (2004–2005) to Wave 7 (2014–2015) of ELSA. Dementia cases were ascertained via self‐ or carer‐report or dementia medication at these waves. The medeff command in Stata version 17 was used to do cross‐section mediation analysis between hearing ability, loneliness, and dementia (Waves 3–7). Path‐specific effects proportional (cause‐specific) hazard models were then used to investigate longitudinal mediation (Waves 2–7).ResultsIn cross‐sectional analyses in Wave 7 alone, loneliness only mediated 5.4% of the total effects of limited hearing on dementia (indirect effects = increased risk of 0.06%; 95% CI: 0.002%–0.15%) under limited hearing and 0.04% (95% CI: 0.001%–0.11%) under normal hearing). In longitudinal analyses, there was no statistical evidence of a mediating role for loneliness in explaining the relationship between hearing ability and time‐to‐dementia (indirect effect estimate hazard ratio = 1.01 (95% CI: 0.99–1.05).ConclusionIn this community‐dwelling sample of English adults, there is a lack of evidence that loneliness mediates the relationship between hearing ability and dementia in both cross‐sectional and longitudinal analyses. However, as the number of dementia cases in this cohort was low, replication in other cohorts with larger sample sizes is required to confirm the absence of a mediated effect via loneliness.
When should electronic medical records reminders for cancer screening stop?—Results from a national physician survey
Authors: Schoenborn Nancy L. , Pollack Craig E. , Boyd Cynthia M. 
Published: May 2023

AbstractBackgroundMany older adults are screened for breast and colorectal cancers beyond guideline recommended thresholds. Electronic medical record (EMR) reminders are commonly used to prompt cancer screening. Behavioral economics theory suggests that changing the default settings for these reminders can be effective to reduce over‐screening. We examined physician perspectives about acceptable thresholds for stopping EMR cancer screening reminders.MethodsIn a national survey of 1200 primary care physicians (PCP) and 600 gynecologists randomly selected from the AMA Masterfile, we asked physicians to choose whether EMR reminders for cancer screening should stop based on a list of criteria that included age, life expectancy, specific serious illnesses, and functional limitations. Physicians could choose multiple responses. PCPs were randomized to questions about breast or colorectal cancer screening.ResultsA total of 592 physicians participated (adjusted response rate 54.1%). 54.6% chose age and 71.8% chose life expectancy as criteria for stopping EMR reminders; only 30.6% chose functional limitations. Regarding age thresholds, 52.4% chose ages ≤75, 42.0% chose a threshold between 75 and 85, 5.6% would not stop reminders even at age 85. Regarding life expectancy thresholds, 32.0% chose ≥10 years, 53.1% chose a threshold between 5 and 9 years, 14.9% would not stop reminders even when life expectancy is <5 years.ConclusionsWe found that many physicians would continue EMR reminders for cancer screening even in light of older age, limited life expectancy, and functional limitations. This may reflect reluctance to stop cancer screening and/or reluctance to stop EMR reminders so that physicians can retain control to decide for individual patients, for example, to assess patient preference and ability to tolerate treatment. There was consensus for stopping EMR reminders at ages 85+ and <5‐year life expectancy. Interventions that seek to reduce over‐screening by suppressing EMR reminders may be important for these groups but may have limited physician buy‐in outside these thresholds.
Caring for aging parents in the last years of life
Authors: Roberts Harley L. , Bollens‐Lund Evan , Ornstein Katherine A. , Kelley Amy S. 
Published: May 2023

AbstractBackgroundAdult children provide a large portion of end‐of‐life caregiving for older adults and make up the majority of caregivers for adults with dementia. Yet research has been limited to the hours of care that primary caregivers provide, neglecting the other ways adult children provide caregiving support. This study aims to describe the caregiving support adult children provide to their parents at the end of life and characterize differences by race and ethnicity and dementia status.MethodsWe conducted a retrospective study using survey responses from the Health and Retirement Study between 2002 and 2018. The sample population (n = 8040) included decedents aged 65 with at least one living adult child at their time of death. Caregiving support was defined as providing financial support, providing help with basic or instrumental activities of daily living (ADLs or IADLs), or coresiding with the care recipient. Respondents were stratified by self‐identified race and ethnicity as Hispanic, non‐Hispanic White, or non‐Hispanic Black. Respondents were further stratified by dementia and marital status.ResultsBlack and Hispanic respondents without dementia were more likely to report receiving financial help from (28.0% and 25.9%) or coresiding with their adult children (38.9% and 49.7%) compared to White respondents (15.0% receiving financial help and 23.3% coresiding) (p < 0.05). Among respondents with dementia, 47.1% of both Black and Hispanic respondents reported coresiding with their adult children, compared to only 24.6% of White respondents (p < 0.05). Notably, married Black and Hispanic respondents reported significantly higher rates of all support types compared to married White respondents (p < 0.05).ConclusionsThe majority of older adults at the end of life receive some form of care and support from their adult children, with Black and Hispanic older adults receiving particularly high rates of care and support from their adult children regardless of dementia or marital status.
Evaluating an adapted reverse categorisation task to assess cognitive flexibility in young children with Down syndrome
Authors: Van Deusen K. , Prince M. A. , Thurman A. J. , Esbensen A. J. , Patel L. R. , Abbeduto L. , Walsh M. M. , Daunhauer L. A. , Feigles R. T. , Fidler D. J. 
Published: May 2023

AbstractBackgroundAccurate measurement of cognitive skills is necessary to advance both developmental and intervention science for individuals with Down syndrome (DS). This study evaluated the feasibility, developmental sensitivity and preliminary reliability of a reverse categorisation measure designed to assess cognitive flexibility in young children with DS.MethodsSeventy‐two children with DS ages 2.5–8 years completed an adapted version of a reverse categorisation task. Twenty‐eight of the participants were assessed again 2 weeks later for retest reliability.ResultsThis adapted measure demonstrated adequate feasibility and developmental sensitivity, and preliminary evidence for test–retest reliability when administered to children with DS in this age range.ConclusionsThis adapted reverse categorisation measure may be useful for future developmental and treatment studies that target early foundations of cognitive flexibility in young children with DS. Additional recommendations for use of this measure are discussed.
Topical growth factor preparations for facial skin rejuvenation: A systematic review
Authors: Quinlan Daniel J. , Ghanem Ali M. , Hassan Haidar 
Published: May 2023

AbstractBackgroundCosmeceutical preparations containing growth factors (GFs) are widely used for facial rejuvenation.ObjectiveWe performed a systematic review to assess the evidence regarding their safety and effectiveness for facial rejuvenation.MethodsElectronic databases (Cochrane Library, EMBASE, MEDLINE, and Scopus) were searched from 2000 to October 2022 for prospective trials and case series assessing topical GF preparations for facial rejuvenation in 10 or more participants.ResultsThirty‐three studies, including 9 randomized controlled trials (RCTs) and 24 uncontrolled case series, representing 1180 participants receiving 23 different topical preparations containing GFs met the inclusion criteria and were included. Of the 33 studies, nine used a placebo or active control. The GF preparations were applied twice daily in all except two studies, with a mean treatment duration of 3 months. Based on the investigator's assessment, preparations containing GFs induce a modest improvement in skin texture (median < 50%), fine lines/wrinkles (median < 35%), and overall facial appearance (median < 20%) versus baseline. Participant‐assessed improvement was generally higher than investigator‐assessed response. Three comparative RCTs showed no statistically significant differences between treatments. Studies were limited by heterogeneity with regard to the source and number of GFs used in the preparations, information about additional ingredients, and lack of standardization in the outcome measures. The preparations were associated with a low risk of adverse events. The persistence of the clinical improvements beyond 6 months is not known.ConclusionsAdministration of topical preparations containing GFs appears to be effective for facial skin rejuvenation, as demonstrated by the investigator‐ and participant‐reported outcome measures.
Effect and safety of probiotics for treating urticaria: A systematic review and meta‐analysis
Authors: Fu Hong‐yu , Yu Hong‐da , Bai Yan‐ping , Yue Li‐feng , Wang Hong‐mei , Li Ling‐ling 
Published: May 2023

AbstractBackgroundTo assess the effect and safety of probiotics for treating urticaria.MethodsRandomized controlled trial (RCT) papers on the probiotics treatment published before May 2019 were retrieved from various databases like PubMed, EMbase, MEDLINE (Ovid), SCI‐Hub, Springer, ClinicalKey, VIP, and CNKI. The treatment plan that we include are oral administration of single probiotic, multiple probiotics, and the combination of probiotics and antihistamines. Meta‐analysis of the data was performed by RevMan 5.3 software.ResultsA total of nine RCT papers were included: four papers for oral administration of single probiotic, three papers for oral administration of multiple probiotics, and two papers for oral administration of a probiotic combined with antihistamines. The results of meta‐analysis showed that the therapeutic effect of the probiotic group was significantly higher than the control group (placebo or antihistamines) (RR = 1.09, 95% CI: 1.03–1.16, p = 0.006). And compared with the placebo group, the therapeutic effect of single probiotic group was significantly improved (RR = 1.11, 95% CI: 1.01–1.21, p = 0.03). Regarding therapeutic effect, there was no statistically significant difference between the multiple probiotics group and placebo group (RR = 1.00, 95% CI: 0.94 ~ 1.07, p = 0.91); the therapeutic effect of single probiotic combined antihistamine group was significantly higher than the antihistamine group (RR = 1.13, 95% CI: 1.07–1.19, p < 0.0001). Regarding the incidence of adverse reactions, there was no significant difference between the probiotic group and the control group (p = 0.46).ConclusionThe treatment plan of oral administration of probiotics has significant therapeutic effects on urticaria, but the therapeutic effects of the administration of multiple probiotics and the safety of probiotic therapy are still not yet obvious. Some large‐scale, multi‐centered RCT studies are needed in the future for clarification.
Liquidity, Volume, and Order Imbalance Volatility
Authors: BOGOUSSLAVSKY VINCENT , COLLIN‐DUFRESNE PIERRE 
Published: May 2023

ABSTRACTWe examine the dynamics of liquidity using a comprehensive sample of U.S. stocks in the post‐decimalization period. Motivated by a continuous‐time inventory model, we compute a high‐frequency measure of order imbalance volatility to proxy for the inventory risk faced by liquidity providers. We show that high‐frequency order imbalance volatility is an important driver of liquidity and explains the often positive time‐series relation between spread and volume for large stocks, which seems to run counter to most theoretical models. Furthermore, order imbalance volatility is priced in the cross‐section of stock returns.
ScRNA‐seq links dental fibroblasts heterogeneity with mechanoresponsiveness
Authors: Xu Hongyuan , Dai Qinggang , Wang Xinyu , Jin Anting , Yang Yiling , Huang Xiangru , Wang Xijun , Gao Xin , Sun Siyuan , Liu Yuanqi , Zhu Yanfei , Shen Steve GF. , Bian Qian , Jiang Lingyong 
Published: May 2023

AbstractBackground and objectivePeriodontal ligament (PDL) and dental pulp (DP) share a common origin but have distinct biological and mechanical functions. To what extent the mechanoresponsive property of PDL can be attributed to its unique transcriptional profiles of cellular heterogeneity is unclear. This study aims to decipher cellular heterogeneity and distinct mechanoresponsive characteristics of odontogenic soft tissues and their underlying molecular mechanisms.Materials and MethodsA single‐cell comparison of digested human periodontal ligament (PDL) and dental pulp (DP) was performed using scRNA‐seq. An in vitro loading model was constructed to measure mechanoresponsive ability. Dual‐luciferase assay, overexpression, and shRNA knockdown were used to investigate the molecular mechanism.ResultsOur results demonstrate striking fibroblast heterogeneity across and within human PDL and DP. We demonstrated that a tissue‐specific subset of fibroblasts existed in PDL exhibiting high expression of mechanoresponsive extracellular matrix (ECM) genes, which was verified by an in vitro loading model. ScRNA‐seq analysis indicated a particularly enriched regulator in PDL‐specific fibroblast subtype, Jun Dimerization Protein 2 (JDP2). Overexpression and knockdown of JDP2 extensively regulated the downstream mechanoresponsive ECM genes in human PDL cells. The force loading model demonstrated that JDP2 responded to tension and that knockdown of JDP2 effectively inhibited the mechanical force–induced ECM remodeling.ConclusionsOur study constructed the PDL and DP ScRNA‐seq atlas to demonstrate PDL and DP fibroblast cellular heterogeneity and identify a PDL‐specific mechanoresponsive fibroblast subtype and its underlying mechanism.