bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field
Authors: Fullerton Josie , Bettencourt Conceicao , Daniels Michael , Mclean Fiona , Simpson Susan , Smith Adam , Woodling Nathan , Kerr Fiona 
Published: March 2023

Background Effective development and retention of talented early-career researchers (ECRs) is essential to the continued success of biomedical science research fields. To this end, formal mentorship programmes (where researchers are paired with one or more mentors beyond their direct manager) have proven to be successful in providing support and expanding career development opportunities. However, many programmes are limited to pools of mentors and mentees within one institute or geographical area, highlighting that cross-regional connections may be a missed opportunity in many mentorship schemes. Methods Here, we aimed to address this limitation through our pilot cross-regional mentorship scheme, creating reciprocal mentor-mentee pairings between two pre-established networks of Alzheimer’s Research UK (ARUK) Network-associated researchers. We carefully created 21 mentor-mentee pairings between the Scotland and University College London (UCL) networks in 2021, with surveys conducted to assess mentor/mentee satisfaction with the programme. Results Participants reported very high satisfaction with the nature of the pairings and the mentors’ contribution to the career development of mentees; a majority also reported that the mentorship scheme increased their connections outside of their home network. Our assessment of this pilot programme is that it supports the utility of cross-regional mentorship schemes for ECR development. At the same time, we highlight the limitations of our programme and recommend areas for improvement in future programmes, including greater consideration of support for minoritized groups and the need for additional training for mentors. Conclusions In conclusion, our pilot scheme generated successful and novel mentor-mentee pairings across pre-existing networks; both of which reported high satisfaction with pairings, ECR career and personal development, and the formation of new cross-network connections. This pilot may serve as a model for other networks of biomedical researchers, where existing networks within medical research charities can act as a scaffold to build new cross-regional career development opportunities for researchers.
Retail Sample Boxes: Counteracting the Adverse Effect of Accelerated Learning via Future Credit
Authors: Yazdani Alireza , Çil Eren B. , Pangburn Michael 
Published: March 2023

Problem definition: Consumers often try a few varieties of an experience product before establishing a shopping routine. In retailing, a sample box typically refers to a package of multiple trial-sized varieties within a product category. Sample boxes potentially create value by helping consumers resolve their uncertainties regarding these varieties earlier and at a lower cost. In this paper, we study how firms and consumers share this added value under different market scenarios. We also derive the optimal pricing of sample boxes in product categories for which consumers make ongoing purchases over time. Academic/practical relevance: We thus extend the literature by proposing a framework that integrates sequential search and seller-induced learning. Methodology: We analyze a firm’s pricing decisions when consumers either purchase full-sized options sequentially or bypass that process via a sample box. We use dynamic programming to analyze consumers’ search problem (in the absence of a sample box) and nonlinear optimization to analyze the firm’s problem. Results: As anticipated, the informational value of a sample box yields an optimal price premium relative to the prices of individual products. Despite this price premium, we show that the firm’s expected profit may decrease because a sample box accelerates consumer learning, and thus, it may help consumers settle upon an outside option earlier. We establish that a firm can reverse the potential adverse profit impact of selling sample boxes by introducing an optimally specified future credit. Managerial implications: Offering sample boxes is a common practice in retailing. Contrasting the resulting expected profits with and without the sample box option, our results highlight that managers may be ill-advised to offer a sample box in the absence of the future credit mechanism. This study is the first to address the pricing of sample boxes and show the optimality of offering credit toward a subsequent purchase. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.1206 .
Humanitarian Relief Distribution Problem: An Adjustable Robust Optimization Approach
Authors: Avishan Farzad , Elyasi Milad , Yanıkoğlu İhsan , Ekici Ali , Özener O. Örsan 
Published: March 2023

Management of humanitarian logistics operations is one of the most critical planning problems to be addressed immediately after a disaster. The response phase covers the first 12 hours after the disaster and is prone to uncertainties because of debris and gridlock traffic influencing the dispatching operations of relief logistics teams in the areas affected. Moreover, the teams have limited time and resources, and they must provide equitable distribution of supplies to affected people. This paper proposes an adjustable robust optimization approach for the associated humanitarian logistics problem. The approach creates routes for relief logistics teams and decides the service times of the visited sites to distribute relief supplies by taking the uncertainty in travel times into account. The associated model allows relief logistics teams to adjust their service decisions according to the revealed information during the process. Hence, our solutions are robust for the worst-case realization of travel times, but still more flexible and less conservative than those of static robust optimization. We propose novel reformulation techniques to model these adjustable decisions. The resulting models are computationally challenging optimization problems to be solved by exact methods, and, hence, we propose heuristic algorithms. The state-of-the-art heuristic, which is based on clustering and a dedicated decision-rule algorithm, yields near-optimal results for medium-sized instances and is scalable even for large-sized instances. We have also shown the effectiveness of our approach in a case study using a data set obtained from an earthquake that hit the Van province of Turkey in 2011. History: This paper has been accepted for the Transportation Science Special Issue on Emerging Topics in Transportation Science and Logistics. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2023.1204 .
Student nurses' knowledge of and attitudes toward palliative care in the Middle East: an integrative review
Authors: Alomari Domam , Abu-Snieneh Hana Mohammad 
Published: March 2023

Background: Palliative care is one of the most important areas of practice because it includes caring for vulnerable people who are mostly in their last stage of life. Palliative care is a relatively new specialty in the Middle East and little is known about student nurses' knowledge of and attitudes towards it. Aim: The aim of this study was to explore students' knowledge of and attitudes towards palliative care in the Middle East, and to use the findings to make recommendations to higher education institutions about its importance. Design: An integrative review following an established framework was used. Hawker's Assessment Tool was employed to evaluate the quality of the research articles. Results: The search found seven quantitative studies from four countries in the Middle East. Their focus was on students' knowledge (n=5) and attitudes (n=2). The number of participants ranged from 110 to 452, with knowledge scores ranging from 5.23 to 8.0 out of 20 on all or part of the Palliative Care Quiz for Nursing. Students' attitudes were marginally positive toward palliative care and dying patients. Conclusion: There are few studies in the Middle East investigating student nurses' knowledge of and attitude toward palliative care; consequently, more attention needs to be given to this area of practice.
Identification of circRNA-miRNA-mRNA regulatory network and its role in cardiac hypertrophy
Authors: Gong Ke , Yang Kai , Xie Ting , Luo Yong , Guo Hui , Tan Zhiping , Chen Jinlan , Wu Qin , Gong Yibo , Wei Luyao , Luo Jinwen , Yao Yao , Yang Yifeng , Xie Li 
Published: March 2023

Background
Hypertrophic cardiomyopathy (HCM) is a grave hazard to human health. Circular RNA (circRNAs) and micro RNA (miRNAs), which are competitive endogenous RNA, have been shown to play a critical role inHCM pathogenicity. However, to a great extent, the biological activities of ceRNA in HCM pathophysiology and prognosis remain to be investigated.

Materials and methods
By analyzing the expression files in the Gene Expression Comprehensive (GEO) database, differentially expressed (DE) circRNAs, miRNAs, and mRNAs in HCM were identified, and the target molecules of circRNAs and miRNAs were predicted. The intersection of the differentially expressed RNA molecules and the expected target was then calculated, and a ceRNA network was subsequently constructed using RNA molecules. Using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, the potential etiology was elucidated. qPCR was used to validate a portion of the hub gene using Angiotensin II to generate a cell hypertrophy model.

Results
Three large-scale HCM sample datasets were extracted from the GEO database. After crossing these molecules with their expected targets, the circRNA-miRNA-mRNA network had two DEcircRNAs, two DEmiRNAs, and thirty DEmRNAs, compared to normal tissues. Functional enrichment analysis of GO and KEGG demonstrated that many of the HCM pathways and mechanisms were associated with calcium channel release, which is also the primary focus of future research. The qPCR results revealed that circRNA, miRNA, and mRNA expression levels were different. They may include novel noninvasive indicators for the early screening and prognostic prediction of HCM.

Conclusion
In this study, we hypothesized a circRNA-miRNA-mRNA regulation network that is closely related to the progression and clinical outcomes of HCM and may contain promising biomarkers and treatment targets for HCM.
The impact of identified agility components on project success—ICT industry perspective
Authors: Kanski Lukasz , Budzynska Katarzyna , Chadam Jan 
Published: March 2023

Context
The complexity of modern economic processes, along with the pressure from competition, the increasing client expectations and the need to introduce changes in the course of project implementation have led to a great interest in agile management methods. Therefore, the answer the question whether the implementation of an agile approach to project management can contribute to the project success is gaining relevance in a changing and inconsistent environment.

Objective
This study attempts to answer the question which aspects of agility and in what manner can influence the final outcome of project work? The underlying objective of the study was to identify the conditions and success factors of implemented projects.

Method
This paper presents the results of a survey conducted in companies in ICT sector. For this purpose, a number of reports and materials provided by organisations and associations dealing with project management issues, in particular ICT projects, were analysed, complemented with data obtained from statistical offices and financial institutions. For the purposes of the own study, an original questionnaire was developed to identify critical factors for project success, in particular the defined agile components.

Results
On the basis of the conducted survey it can be concluded that the presence and high level agility is conducive to successful projects. It is the high level of agility supporting project activities that is essential for success. Of no less importance are the people and interactions between them, as well as self-organising teams. They are crucial for a positive evaluation of the project activities.

Conclusions
Identification of the relationship between selected agility components and project success components allowed recommendations for solutions and attitudes that increase the chances of success in project management to be formulated. The synergy of individual agile components applied that increases the chances for project success.
Italian cross-cultural adaptation of the Quality of Communication questionnaire and the 4-item advance care planning engagement questionnaire
Authors: De Panfilis Ludovica , Veronese Simone , Perin Marta , Cascioli Marta , Farinotti Mariangela , Kruger Paola , Zagarella Roberta M. , Curtis J. R. , Sudore Rebecca L. , Nielsen Elizabeth L. , Engelberg Ruth A. , Giordano Andrea , Solari Alessandra ,   on behalf of the ConCure-SM project
Published: March 2023

Background
Advance care planning (ACP) is influenced by several factors (e.g., patient’s readiness to engage, clinician’s skills, and the cultural environment). Availability of reliable and valid self-reported measures of the ACP domains is crucial, including cross-cultural equivalence.

Aim
To culturally adapt into Italian the 19-item Quality of Communication (QOC) and the 4-item ACP Engagement (4-item ACP-E) questionnaires.

Methods
We translated and culturally adapted the two questionnaires and produced a significant other (SO) version of the QOC (QOC-SO). Each questionnaire was field tested via cognitive interviews with users: nine patients (QOC, 4-item ACP-E) and three SOs (QOC-SO) enrolled at three palliative care services.

Results
We made minor changes to 5/19 QOC items, to improve clarity and internal consistency; we changed the response option ‘didn’t do’ into ‘not applicable’. Finally, we slightly revised the QOC to adapt it to the paper/electronic format. QOC debriefing revealed that the section on end of life was emotionally challenging for both patients and SOs. We simplified the 4-item ACP-E layout, added a sentence in the introduction, and revised the wording of one item, to improve coherence with the Italian ACP legislation. ACP-E debriefing did not reveal any major issue.

Conclusions
Results were satisfactory in terms of semantic, conceptual and normative equivalence of both questionnaires. Acceptability was satisfactory for the 4-item ACP-E, while findings of the QOC cognitive debriefing informed a major amendment of a pilot trial protocol on ACP in multiple sclerosis (ConCure-SM): use of the interviewer version only, in an adaptive form. Psychometric testing of both questionnaires on a large, independent sample will follow.
Cross-sectional study to describe allergic rhinitis flare-ups and associated airways phenotype in house dust mite sensitization
Authors: de Gabory Ludovic , Amet Sabine , Le Maux Annelore , Meunier Jean-Pierre , Chartier Antoine , Chenivesse Cécile 
Published: March 2023

Objectives
To quantify and describe flare-ups of house dust mite allergic rhinitis (HDM-AR) which had occurred during the last 12 months in a population of adults and children candidate for Allergen ImmunoTherapy (AIT). Next, to identify associated clinical features.

Materials and methods
This was an observational, multicenter, cross-sectional study that included patients aged ≥ 5 years with HDM-AR eligible for AIT and without prior AIT for at least 12 months. Flare-ups were all period with impairment of quality of life (QoL) and requiring a change in their usual treatment. Data were collected using medical records and patient questionnaires. Variables associated with the occurrence of ≥ 2 AR flare-ups were identified.

Results
1,701 patients were included (average age: 23 years, 51.5% males, 30.4% children, 17.7% adolescents and 51.9% adults). Severe and persistent AR affected 70.9% of them and 53.7% showed polysensitization. Asthma was associated with AR in 34.4% and was well-controlled in 58.5%. The occurrence of at least one AR flare-up in the year was reported by 77.7%, with an annual rate in the whole population of 2.6 ± 3.9 and a duration of 14.1 ± 17.1 days. Deeply or moderately AR-related degraded QoL was experienced by 39.5% and 64.6%, respectively. The occurrence of ≥ 2 AR flare-ups was reported by 54.5% and was associated with polysensitization, AR intermittence and severity.

Conclusion
AR flare-ups are frequent and impair QoL in HDM-allergic patients, suggesting that it could be considered as therapeutic targets.
Emergency department reorganisation introducing increased autonomy: A mixed effects approach to evaluate the effects of a national policy
Authors: Tipsmark Line Stjernholm , Obel Børge , Andersson Tommy , Søgaard Rikke 
Published: March 2023

Background
In 2007, a Danish national policy to future-proof emergency department (ED) performance was launched. The policy included several recommendations for the management and organisation of care that essentially introduced greater ED autonomy. In this study, we evaluate the effects of increased ED autonomy on readmission, mortality and episode costs for two large patient groups.

Method
A non-randomised stepped wedge study-design where all EDs gradually implemented the policy at different steps during the study period (2008–2016). The timing and extent of policy implementation was determined from a retrospective cross-sectional survey of all 21 Danish EDs. This was linked to all episodes of hip fracture (n = 79,697) and erysipelas (n = 39,900) identified in the Nation Patient Registry and with episode-level outcomes. Mixed effect models were specified for the outcomes of 30-day readmission, 30-day mortality and episode costs, and adjusted for relevant ED- and episode-level heterogeneity.

Results
Increased ED autonomy was associated with more readmissions (p<0.05) and higher episode costs (p<0.001) in hip fracture episodes. In erysipelas episodes, no general associations were found. When restricted to night-time admissions, increased ED autonomy was associated with poorer outcomes for erysipelas episodes and increased episode costs for both patient groups.

Conclusion
The intended policy effects were not found for these two patient groups; in fact, reorganisation appeared to have harmed hip fracture patients and increased episode costs. Uncertainty remains regarding the longer-term consequences.
The relative age effect is widespread among European adult professional soccer players but does not affect their market value
Authors: Bezuglov Eduard , Morgans Ryland , Butovskiy Mikhail , Emanov Anton , Shagiakhmetova Larisa , Pirmakhanov Bekzhan , Waśkiewicz Zbigniew , Lazarev Artemii 
Published: March 2023

Background
The relative age effect (RAE) is most prevalent in highly competitive youth soccer and persists to a lesser extent in senior soccer. However, it is known that soccer players born in the second half of the year are as successful at senior level, indicating that they are equally talented although under-represented at youth level due to bias during the selection process, in which the emphasis is on more pronounced physical qualities in a specific period of time. Examining the prevalence of the RAE among professional soccer players depending on the level of competition and playing position, as well as analyzing the relationship between the player’s birth quarter and market value, are of scientific interest.

Methods
The dates of birth, playing position, and market value of all adult male soccer players included in the final rosters of teams from the top-division of 54 European countries, listed on www.transfermarkt.com on August 15th, 2020, were analyzed (18,429 soccer players in total). All players were categorized into four groups according to the quarter of birth (Q) and playing position. All teams were further sub-divided in groups depending on the soccer clubs’ level of representation in the UEFA Champions League.

Results
Of 18,429 players, 30.9% were born in Q1, 25.7% in Q2, 23.8% in Q3 and 19.6% in Q4. The number of soccer players born in Q1 was lower in less competitive leagues. The number of players born in Q1 decreased as the level of competition decreased; the highest percentage of these players was observed in clubs that are among the top 50 ranked in UEFA or compete in the most prestigious European championships. The RAE was less pronounced in teams that participate in lower competitive championships. There was no significant difference in market value between players playing position and level of competition when born in different quarters. Although, the most expensive soccer players in the European championships were late-born forwards. Players of various groups differed in their market value.

Conclusions
The RAE is currently prevalent in all the most competitive senior soccer leagues and teams in Europe regardless of playing position. There are no significant differences in market value between players of the same playing position and level of competition when born in different quarters. The most expensive soccer players in the European championships are forwards born in Q4. These findings may indicate that the under-representation of “late-born” soccer players in youth, and then consequently in adult soccer, is not associated with lower talent, but with other factors, possibly based on physiological characteristics and socio-cultural factors. Further measures are needed to mitigate the discriminatory effects of selection bias based on the RAE.
Systematic screening versus clinical gestalt in the diagnosis of pulmonary embolism in COVID-19 patients in the emergency department
Authors: Luu Inge H. Y. , Frijns Tim , Buijs Jacqueline , Krdzalic Jasenko , de Kruif Martijn D. , Mostard Guy J. M. , ten Cate Hugo , Martens Remy J. H. , Mostard Remy L. M. , Leers Math P. G. , van Twist Daan J. L. 
Published: March 2023

Background
Diagnosing concomitant pulmonary embolism (PE) in COVID-19 patients remains challenging. As such, PE may be overlooked. We compared the diagnostic yield of systematic PE-screening based on the YEARS-algorithm to PE-screening based on clinical gestalt in emergency department (ED) patients with COVID-19.

Methods
We included all ED patients who were admitted because of COVID-19 between March 2020 and February 2021. Patients already receiving anticoagulant treatment were excluded. Up to April 7, 2020, the decision to perform CT-pulmonary angiography (CTPA) was based on physician’s clinical gestalt (clinical gestalt cohort). From April 7 onwards, systematic PE-screening was performed by CTPA if D-dimer level was ≥1000 ug/L, or ≥500 ug/L in case of ≥1 YEARS-item (systematic screening cohort).

Results
1095 ED patients with COVID-19 were admitted. After applying exclusion criteria, 289 were included in the clinical gestalt and 574 in the systematic screening cohort. The number of PE diagnoses was significantly higher in the systematic screening cohort compared to the clinical gestalt cohort: 8.2% vs. 1.0% (3/289 vs. 47/574; p<0.001), even after adjustment for differences in patient characteristics (adjusted OR 8.45 (95%CI 2.61–27.42, p<0.001) for PE diagnosis). In multivariate analysis, D-dimer (OR 1.09 per 1000 μg/L increase, 95%CI 1.06–1.13, p<0.001) and CRP >100 mg/L (OR 2.78, 95%CI 1.37–5.66, p = 0.005) were independently associated with PE.

Conclusion
In ED patients with COVID-19, the number of PE diagnosis was significantly higher in the cohort that underwent systematic PE screening based on the YEARS-algorithm in comparison with the clinical gestalt cohort, with a number needed to test of 7.1 CTPAs to detect one PE.