bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environment
Authors: Bertoni Daniel 
Published: March 2023

Abstract
Roman attitudes to the environment—that place where culture and nature meet—blend appreciation for the land’s usefulness, its divinity, and its beauty. Musings on the natural world appear in agricultural treatises, and philosophers and poets consider how nature is wild and tamed, productive and destructive. Drawing on ecocritical theory and the ways humans create and shape their interactions with the natural world, this chapter traces the varied conceptions of the Roman environment through the trope of the locus amoenus, the gods of fields and groves, and the quintessentially Roman appreciation of the beauty of a fertile field. What emerges is an appreciation for nature in its interactions with people, a reciprocal relationship considered to benefit both people and place.
Latin Neoplatonism
Authors: Kijewska Agnieszka 
Published: March 2023

AbstractThis chapter discusses the selected topics from the Latin tradition of Neoplatonism to give the reader some idea about the richness and variety of that tradition. The authors chosen belong to late antiquity and the early Middle Ages, and represent the three currents of the Neoplatonic tradition that developed in this period: Augustinian, Dionysian, and Boethian Neoplatonism. Each of these forms of Neoplatonism was started in Christian antiquity by a “founding father” of its own, was developed by some medieval followers, and had its beginning in the philosophical schools of pagan antiquity. The chapter presents the way all three revolved around the same principal theme, that is, man as microcosm, yet each of them stressed a different aspect of that rich subject.
Seneca and Stoic Moral Psychology
Authors: Reydams-Schils Gretchen 
Published: March 2023

Abstract
The first part of this chapter addresses the question of the influence of Platonic psychology on Seneca. Seneca has often been interpreted as “eclectic,” and so to assess the extent of his commitment to Stoic views, requires a sense of how he handles material from other schools of thought, and especially Platonism. The second part, takes a closer look at one of his more technical expositions, his analysis of the pre-emotions and anger. Such accounts, however, need to be balanced with other features of his writings. The range of expressions that Seneca uses in his On Tranquility of Mind to capture the different ways in which a human being can relate to him- or herself provides a good window onto his overall approach. Finally, no picture of Seneca’s moral psychology would be complete without addressing how a human being relates to others and to the order of the cosmos.
The Epicureanism of Lucretius
Authors: O’Keefe Tim 
Published: March 2023

Abstract
What is distinctive about Lucretius’s version of Epicureanism? The answer might appear to be “nothing,” for two reasons. First, Epicureanism in general is doctrinally conservative, with followers of Epicurus claiming to follow his authority. Second, Lucretius claims to be merely transmitting the arguments of his beloved master Epicurus in a pleasing manner. I contend that these considerations do not prevent De rerum natura from presenting a distinct version of Epicureanism. Its arguments in physics are almost certainly drawn from Epicurus himself. But in the examples Lucretius uses to illustrate these arguments, as well as in his descriptions of things like the fear of death and the formation of society, Lucretius delivers unexpected insights into human psychology, ones not clearly present in the other sources we have on Epicureanism. Furthermore, the way in which Lucretius presents his arguments can rightly be considered original philosophically and not just poetically. In his use of literary and rhetorical methods of persuasion alongside his argumentation, Lucretius alone among the Epicureans shows a sensitivity to the need to present his arguments in a way that also takes into account the biases, stereotypes, and other psychological factors that hinder his audience from accepting the healing gospel of Epicurus.
Hyaluronic acid methacrylate/laponite hydrogel loaded with BMP4 and maintaining its bioactivity for scar-free wound healing
Authors: Chang Likun , Xu Yulong , Wu Zhouying , Shao Yichun , Yu Dan , Yang Wenyue , Ye Liyuan , Wang Xinyu , Li Binbin , Yin Yixia 
Published: March 2023

AbstractScar-free wound healing is a challenging process due to the excessive deposition of extracellular matrix and collagen. To overcome this issue, hydrogels with superior biochemical and mechanical properties have been used in combination with medicinal compounds as wound dressings. In this study, a novel composite hydrogel consisting of double-crosslinked photocurable hyaluronic acid methacrylate (HAMA) and Laponite (Lap) loaded with bioactive bone morphogenetic protein 4 (BMP4) was developed and thoroughly characterized for its properties such as degradation, morphology, porosity, compression, skin adhesion and load release. The effect of the HAMA/Lap/BMP4 hydrogel was evaluated through both in vitro and in vivo experiments. In the in vivo rabbit ear-scar model, the HAMA/Lap/BMP4 hydrogel dressing was found to reduce scar-related expressions of α-SAM and decrease the ratio of collagen Ι/III in wounded tissue. Additionally, histopathological examination indicated that the HAMA/Lap/BMP4 hydrogel-treated groups exhibited enhanced wound repair and increased levels of collagen maintenance compared to other standard groups, ultimately leading to scarless wound healing. Therefore, this sustained-release photocurable HAMA/Lap/BMP4 hydrogel offers a therapeutic approach for scar-free wound healing.
Syntactic Network Analysis in Schizophrenia-Spectrum Disorders
Authors: Ciampelli Silvia , de Boer Janna N , Voppel Alban E , Corona Hernandez Hugo , Brederoo Sanne G , van Dellen Edwin , Mota Natalia B , Sommer Iris E C 
Published: March 2023

AbstractBackgroundLanguage anomalies are a hallmark feature of schizophrenia-spectrum disorders (SSD). Here, we used network analysis to examine possible differences in syntactic relations between patients with SSD and healthy controls. Moreover, we assessed their relationship with sociodemographic factors, psychotic symptoms, and cognitive functioning, and we evaluated whether the quantification of syntactic network measures has diagnostic value.Study DesignUsing a semi-structured interview, we collected speech samples from 63 patients with SSD and 63 controls. Per sentence, a syntactic representation (ie, parse tree) was obtained and used as input for network analysis. The resulting syntactic networks were analyzed for 11 local and global network measures, which were compared between groups using multivariate analysis of covariance, considering the effects of age, sex, and education.ResultsPatients with SSD and controls significantly differed on most syntactic network measures. Sex had a significant effect on syntactic measures, and there was a significant interaction between sex and group, as the anomalies in syntactic relations were most pronounced in women with SSD. Syntactic measures were correlated with negative symptoms (Positive and Negative Syndrome Scale) and cognition (Brief Assessment of Cognition in Schizophrenia). A random forest classifier based on the best set of network features distinguished patients from controls with 74% cross-validated accuracy.ConclusionsExamining syntactic relations from a network perspective revealed robust differences between patients with SSD and healthy controls, especially in women. Our results support the validity of linguistic network analysis in SSD and have the potential to be used in combination with other automated language measures as a marker for SSD.
World Society Corridors: Partnership Patterns in the Spread of Human Rights
Authors: Sendroiu Ioana , Levi Ron 
Published: March 2023

Abstract
Considerable sociological work shows that the human rights regime is rapidly expanding through isomorphic processes. We provide new insight into human rights diffusion through an analysis of the Universal Periodic Review (UPR), a global forum in which all states receive human rights recommendations from their peers. We convert the roughly 50,000 recommendations from the first two cycles of the UPR into a relational dataset of states making and receiving recommendations, inductively modeling this process of human rights diffusion through latent class regression. Building on research in the new institutionalism, we find that asymmetric relationships between states make it less likely for human rights recommendations to be accepted, with accepted recommendations tending to be more general and easier to implement. We argue that these partnership patterns provide evidence for normative corridors that give world society its shape. By drawing together world society approaches with relational sociology, we develop new insights into the structuration of human rights and normative change more broadly.
Realizing the Full Potential of Advanced Microscopy Approaches for Interrogating Plant-Microbe Interactions
Authors: Czymmek Kirk J. , Duncan Keith E. , Berg Howard 
Published: March 2023

Microscopy has served as a fundamental tool for insight and discovery in plant-microbe interactions for centuries. From classical light and electron microscopy to corresponding specialized methods for sample preparation and cellular contrasting agents, these approaches have become routine components in the toolkit of plant and microbiology scientists alike to visualize, probe and understand the nature of host-microbe relationships. Over the last three decades, three-dimensional perspectives led by the development of electron tomography, and especially, confocal techniques continue to provide remarkable clarity and spatial detail of tissue and cellular phenomena. Confocal and electron microscopy provide novel revelations that are now commonplace in medium and large institutions. However, many other cutting-edge technologies and sample preparation workflows are relatively unexploited yet offer tremendous potential for unprecedented advancement in our understanding of the inner workings of pathogenic, beneficial, and symbiotic plant-microbe interactions. Here, we highlight key applications, benefits, and challenges of contemporary advanced imaging platforms for plant-microbe systems with special emphasis on several recently developed approaches, such as light-sheet, single molecule, super-resolution, and adaptive optics microscopy, as well as ambient and cryo-volume electron microscopy, X-ray microscopy, and cryo-electron tomography. Furthermore, the potential for complementary sample preparation methodologies, such as optical clearing, expansion microscopy, and multiplex imaging, will be reviewed. Our ultimate goal is to stimulate awareness of these powerful cutting-edge technologies and facilitate their appropriate application and adoption to solve important and unresolved biological questions in the field. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
Characterization of Podosphaera macularis on the Most Prevalent Hop Genotype in the Pacific Northwest
Authors: Gent David H. , Block Mary , Cooperider Carly R. , Wiseman Michele S. 
Published: March 2023

As of 2020, the hop cultivar ‘HBC 394’, trademarked name Citra brand, was the most widely planted hop cultivar in Washington, Oregon, and Idaho, with the acreage harvested in all three states nearly doubling from 2018 to 2020. This research characterized the pathogenic diversity of isolates of Podosphaera macularis on Citra brand and determined whether isolates with local or general adaption have emerged coincident with Citra brand becoming the most widely planted cultivar in the region. Among 27 isolates obtained from Citra brand, all could infect differential cultivars possessing the R-genes Rb, R3, and R5; nine isolates were also virulent on the differentials for R4 and R6. In a broader collection of 92 other isolates from Citra brand, 91 (98.9%) lacked R6 virulence. Inoculations of seven P. macularis isolates with complex virulence onto detached leaves of Citra brand all produced disease, indicating that a known major R-gene does not predict the powdery mildew phenotype in Citra brand. Citra brand-derived isolates and isolates representing the three predominant pathogenic races of P. macularis in the Pacific Northwest had no major difference in aggressiveness when inoculated on Citra brand leaves. Citra brand-derived isolates also caused disease levels on a range of hop cultivars similar to levels caused by isolates derived from other hop cultivars. These findings adduce that P. macularis isolates found on Citra brand may have varied phenotypes associated with known Pacific Northwest pathogen races. However, currently, isolates derived from Citra brand display neither local adaptation for increased virulence on Citra brand nor general adaptation for enhanced virulence on other cultivars. [Formula: see text] The author(s) have dedicated the work to the public domain under the Creative Commons CC0 “No Rights Reserved” license by waiving all of his or her rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law, 2023.
Gut microbial metabolite butyrate improves anticancer therapy by regulating intracellular calcium homeostasis
Authors: Che Yibin , Chen Guoyu , Guo Qianqian , Duan Yourong , Feng Haizhong , Xia Qiang 
Published: March 2023

Background and Aims:
Gut microbiota are recognized to be important for anticancer therapy, yet the underlying mechanism is not clear. Here, through the analysis of clinical samples, we identify the mechanism by which the gut microbial metabolite butyrate inhibits HCC and then explore new strategies for HCC treatment.

Approach and Results:
In our study, we demonstrate that gut microbial metabolite butyrate improves anticancer therapy efficacy by regulating intracellular calcium homeostasis. Using liquid chromatography-mass spectrometry analysis, we found that butyrate metabolism is activated in HCC patients compared with healthy individuals. Butyrate levels are lower in the plasma of HCC patients by gas chromatography-mass spectrometry (GC-MS) analysis. Butyrate supplementation or depletion of short-chain Acyl-CoA dehydrogenase (SCAD) gene (ACADS), encoding a key enzyme for butyrate metabolism, significantly inhibits HCC proliferation and metastasis. The profiling analysis of genes upregulated by butyrate supplementation or ACADS knockdown reveals that calcium signaling pathway is activated, leading to dysregulation of intracellular calcium homeostasis and production of reactive oxygen species. Butyrate supplementation improves the therapy efficacy of a tyrosine kinase inhibitor sorafenib. On the basis of these findings, we developed butyrate and sorafenib coencapsulated mPEG-PLGA-PLL nanoparticles coated with anti-GPC3 antibody (BS@PEAL-GPC3) to prolong the retention time of drugs and enhance drug targeting, leading to high anticancer efficacy. BS@PEAL-GPC3 nanoparticles significantly reduce HCC progression. In addition, BS@PEAL-GPC3 nanoparticles display excellent HCC targeting with excellent safety.

Conclusions:
In conclusion, our findings provide new insight into the mechanism by which the gut microbial metabolites inhibit HCC progression, suggesting a translatable therapeutics approach to enhance the clinical targeted therapeutic efficacy.
Anterior Chamber Washout During Ahmed Valve Glaucoma Surgery Reduces the Incidence of Hypertensive Phase
Authors: Chang Melissa M. , Yang Christopher D. , Ly Huy Q. , Minckler Donald S. , Lin Ken Y. 
Published: March 2023

Précis:
Intraoperative anterior chamber (AC) washout reduces the odds of hypertensive phase (HP) by 95% compared with those not receiving washout during Ahmed glaucoma implant (AGI), suggesting AC washout is an effective prophylaxis for postoperative HP.

Purpose:
To characterize the incidence of postoperative HP in patients receiving AC washout at the time of AGI.

Patients and Methods:
A total of 24 patients with medically refractory glaucoma who underwent AGI surgery at a tertiary academic medical center in Southern California from December 2018 through March 2021 were included in this retrospective comparative case series. Patients who received a pediatric implant and underwent concurrent intraocular surgery or did not complete a minimum of 6 months of follow-up were excluded. Nine patient’s eyes received AC washout and 15 controls that were analyzed through 6 months postprocedure. HP was defined as intraocular pressure (IOP) above 21 mm Hg within 6 months postprocedure with maximum tolerated medical therapy. AC washout was performed by irrigating the AC with a 5 mL balanced salt solution before placing the tube of the AGI into the AC. The rate of postoperative HP, defined as peak IOP >21 mm Hg, at 6 months follow-up, was observed as the primary outcome measure.

Results:
Patients included in the study had a high mean preoperative IOP (X̅ = 44.11, SD = 13.85). There were no baseline differences between the washout and control groups. The odds of HP were significantly reduced (odds ratio: 0.050; 95% CI: 0.004, 0.706; P = 0.027) for patients who underwent intraoperative AC washout compared with those who did not. Bivariate analysis of subject baseline characteristics revealed that only washout status was significantly different in subjects with HP compared with subjects without HP (P = 0.015). A multivariate logistic regression model using washout status and autoimmune conditions as covariates was significant in predicting HP (X
2 (2) = 12.337, P = 0.002), with washout as a significant predictor when controlling for autoimmune comorbidities (P = 0.027).

Conclusions:
AC washout significantly decreases the odds of HP after AGI surgery. AC washout with balanced salt solution adds minimal time and risks to surgery and therefore may be an effective adjunct during AGI placement.
The Success Rate of Glaucoma Drainage Device Revision
Authors: Bouris Ella , de Gainza Agustina , Barsegian Arpine , Caprioli Joseph 
Published: March 2023

Précis:
We report the survival of surgical revision to glaucoma drainage devices for several indications in a large cohort of patients, with an overall success rate of 45% at 36 months.

Purpose:
To evaluate the outcomes of surgical revision for complications of glaucoma drainage devices.

Methods:
Three hundred thirty-five eyes of 318 patients who underwent tube revision or removal at University of California Los Angeles (UCLA) Jules Stein Eye Institute between 1997 and 2019 were included. The pre-defined primary outcome measure was surgical success of the initial revision, defined as resolution of the condition with no additional revisions required, no functionally significant change in vision, and no instances of intraocular pressure > 21 mmHg at 2 consecutive visits postoperatively. Kaplan-Meier survival analysis was applied to evaluate survival at 36 months based on these criteria. The Wilcoxon paired test was used to compare mean preoperative and postoperative intraocular pressure, medication usage, and visual acuity.

Results:
Overall, survival of revised tubes at 36 months was 45%. The 4 most common indications for revision were exposure of the implant (42% of all revisions), occlusion (14%), corneal failure or threat of failure (12%), and hypotony (11%). Survival at 36 months for each of these indications was 44%, 45%, 52%, and 37%, respectively.

Conclusions:
These results suggest that eyes with glaucomatous damage with long-term glaucoma drainage device complications can still have a reasonably successful outcome when a revision is performed. However, with substantial rates of vision loss and a frequent need for additional revisions to manage complications, managing patient expectations for success and making them aware of the likelihood of additional surgeries or failure is important.
Buprenorphine Program Evaluation in a Private Psychiatric Office-Based Practice
Authors: Palmer Joshua , Mitchell Ann M. , Schlenk Elizabeth A. , Mullick Prabir , Lee Heeyoung 
Published: March 2023

Abstract

Purpose
The opioid crisis has contributed to the mortality, morbidity, and rising healthcare costs in the United States. Buprenorphine (BUP) is an effective medication for opioid use disorder. The aims of this quality assurance evaluation of a BUP program were to (a) evaluate the clinic's performance in illicit opioid abstinence and (b) identify patient risk and resilience characteristics to improve patient success in recovery with BUP.

Methods
A retrospective chart review of open (n = 35) and closed (n = 21) cases and a cross-sectional survey in open cases were completed. Adults (aged ≥18 years) who completed 6 months of BUP treatment at a psychiatric clinic were included. Clinical performance was measured with percentages of opioid-negative urine and completed monthly urine drug tests (UDTs) for the first 6 months. Open cases were surveyed regarding risk and resilience characteristics (frequency of opioid cravings and triggers, therapy participation, and coping skills). Descriptive statistics, t test, and chi-square test were used to analyze data.

Results
Average opioid-negative urine was significantly higher in open cases than closed cases (88.57% vs. 74.82%; t = 2.885, p = .004). There was no significant association between open cases (61.4%) and closed cases (73.8%) in completed monthly UDT. Opening and closing of cases stabilized with mandatory monthly UDT. Most individuals reported therapy participation, minimal opioid cravings, and use of distraction to cope with chronic-pain-induced cravings.

Conclusions/Implications
This clinic met benchmarks leading to improved substance recovery. Recommendations include regular evaluations of UDT, cravings, and chronic pain; therapy participation; and continuous quality assurance activities.
End-of-Life Care Planning in Diverse Individuals Across Age Groups
Authors: Rahemi Zahra , Malatyali Ayse , Wiese Lisa Ann Kirk , Dye Cheryl J. 
Published: March 2023

Background:
End-of-life planning helps nurses meet the needs of their patients at a crucial time of life.

Purpose:
This article presents a conceptual model of end-of-life care planning for nurses, especially those in palliative and hospice care, focusing on holistic nursing views.

Methods:
Based on a literature review, we developed a new conceptual model illustrating the concepts and dimensions of end-of-life care planning among diverse individuals across countries, life spans and age groups, ethnographies, and residential statuses.

Results:
This conceptual model includes 3 concepts: personal factors, stakeholders, and environmental and social factors. Each concept encompasses multiple dimensions. The concepts are interrelated and directly related to end-of-life care planning.

Conclusion:
This work addresses the need for a comprehensive end-of-life care planning model and can help enhance the quality of end-of-life care. This article identifies implications for nursing education, practice, and research.