bluuebunny/crossref_metadata_2025_split huggingface dataset:
Administration of Inhibitory Molecules through Nanoparticles in
Breast Cancer Therapy
Authors: Quijia Christian Rafael , Enríquez Andreina Quevedo , Zappia Carlos Daniel , Peroni Roxana Noemí , Chorilli Marlus 
Published: June 2023

Abstract:
According to Global Cancer Statistics, breast cancer is the second leading cause
of mortality in women. While there are several treatments for breast cancer, they are not always
effective. In most cases, after initial treatment, patients may present a low response to
therapy, more severe relapses, and even drug resistance. Hence, more effective and targeted
therapies are needed. Recently, the use of nanoparticles has emerged as a promising alternative
that will allow the controlled release of drugs in response to stimuli, precise delivery to
the site of action, lower levels of toxicity, and fewer side effects. In this review, we provide
an overview of the recent evidence proposing the delivery of inhibitory molecules encapsulated
in nanoparticles as a new therapy for breast cancer that targets the signaling pathways
governing the processes of tumor formation, maintenance, and expansion.
Structure of the Blood Brain Barrier and its Role in the Transporters for the
Movement of Substrates across the Barriers
Authors: S Ankul Singh , Vellapandian Chitra 
Published: June 2023

Abstract:
For the brain to operate normally and to develop with structural integrity in addition to neuronal function,
blood-brain barrier present in brain capillaries serves as a vital barrier mechanism. In addition to the transport barrier
created by membranes, transporters, and vesicular processes, the structure and function of the BBB are summarised.
The physical barrier is created by endothelial tight junctions. The permeability and transport of molecules between
extracellular fluid and plasma are constrained by the presence of tight junctions between neighbouring endothelial
cells. Each solute must pass through both membranes in the luminal and abluminal divisions. The functions of the
neurovascular unit are described, with special emphasis on the pericytes, microglia, and astrocyte endfeet. The luminal
membrane contains five separate facilitative transport mechanisms, each of which is exclusive to a few substrates.
Nevertheless, the import of big-branched and aromatic neutral amino acids is facilitated by two key carriers
(System L and y+) in the plasma membrane. It is asymmetrically present in both membranes. The sodium pump
Na+/K+-ATPase is highly expressed in the abluminal membrane, where many Na+ dependent transport mechanisms
move amino acids against its concentration gradient. The trojan horse strategy, which uses molecular tools to bind
the medication and its formulations, is also preferred in drug delivery. The BBB's cellular structure, the transport
systems unique to each substrate, and the necessity to identify transporters with changes that assist the transfer of
various medications have all been changed in the current work. Nevertheless, to rule out the BBB passage for the
new class of neuroactive medications, the mixing of traditional pharmacology and nanotechnology needs to be focused
on outcomes that show promise.
WITHDRAWN: Monochasma savatieri Inhibits the Migration of the Breast Cancer Cell Line MDA-MB-231
Authors: Gutierrez-Pajares Jorge L. , Zhang Mengya , Ma Funing 
Published: June 2023

This article has been withdrawn from the journal Anti-Cancer Agents in Medicinal Chemistry due to a Conflict of Interest between the authors.
Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.
The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:
It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Analysis of Tolfenamic Acid using a Simple, Rapid, and
Stability-indicating Validated HPLC Method
Authors: Kazi Sadia Hafeez , Sheraz Muhammad Ali , Musharraf Syed Ghulam , Ahmed Sofia , Bano Raheela , Haq Faraz ul , Anwar Zubair , Ali Raahim 
Published: June 2023

Background:
Tolfenamic acid (TA) belongs to the fenamates class of non-steroidal anti-inflammatory drugs. Insufficient information is available regarding the availability of a reliable and validated stability-indicating method for the assay of TA.

Objective:
A relatively simple, rapid, accurate, precise, economical, robust, and stability-indicating RP-HPLC method has been developed to determine TA in pure and tablet dosage forms.

Methods:
The method was validated according to the ICH guideline, and parameters like linearity, range, selectivity, accuracy, precision, robustness, specificity, and solution stability were determined. TLC and FTIR spectrometry were used to ascertain the purity of TA. The specificity was determined with known impurities and after performing forced degradation, while the robustness was established by Plackett-Burman's experimental design. The mobile phase used for the analysis was acetonitrile and water (90:10, v/v) at pH 2.5. The detection of the active drug was made at 280 nm using a C18 column (tR = 4.3 min.). The method's ap-plicability was also checked for the yellow polymorphic form of TA.

Results:
The results indicated that the method is highly accurate (99.39-100.80%), precise (<1.5% RSD), robust (<2% RSD), and statistically comparable to the British Pharmacopoeia method with better sensitivity and specificity.

Conclusion:
It was observed that the stress degradation studies do not affect the method's accuracy and specificity. Hence the proposed method can be used to assay TA and its tablet dosage form.
New Insights into the Relationship between Nutrition and Neuroinflammation
in Alzheimer's Disease: Preventive and Therapeutic Perspectives
Authors: De Marchi Fabiola , Vignaroli Francesca , Mazzini Letizia , Comi Cristoforo , Tondo Giacomo 
Published: June 2023

Abstract:
Neurodegenerative diseases are progressive brain disorders characterized by inexorable
synaptic dysfunction and neuronal loss. Since the most consistent risk factor for developing neurodegenerative
diseases is aging, the prevalence of these disorders is intended to increase with increasing
life expectancy. Alzheimer’s disease is the most common cause of neurodegenerative dementia, representing
a significant medical, social, and economic burden worldwide. Despite growing research to
reach an early diagnosis and optimal patient management, no disease-modifying therapies are currently
available. Chronic neuroinflammation has been recognized as a crucial player in sustaining neurodegenerative
processes, along with pathological deposition of misfolded proteins, including amyloid-β
and tau protein. Modulating neuroinflammatory responses may be a promising therapeutic strategy in
future clinical trials. Among factors that are able to regulate neuroinflammatory mechanisms, diet, and
nutrients represent easily accessible and modifiable lifestyle components. Mediterranean diet and several
nutrients, including polyphenols, vitamins, and omega-3 polyunsaturated fatty acids, can exert antioxidant
and anti-inflammatory properties, impacting clinical manifestations, cognitive decline, and
dementia. This review aims to provide an updated overview of the relationship between neuroinflammation,
nutrition, gut microbiota, and neurodegeneration. We summarize the major studies exploring
the effects of diet regimes on cognitive decline, primarily focusing on Alzheimer’s disease dementia
and the impact of these results on the design of ongoing clinical trials.
Design and Implementation of a Three-phase Asynchronous Motor Intelligent
Test System
Authors: Xie Yongchao , Yan Jun , Shi Jinyan , Duan Shuhua 
Published: June 2023

Background:
The locomotive traction motor has gradually shifted from DC motors to
AC motors in high-speed railways, and the traction motor needs to be regularly maintained and tested
frequently.

Objective:
The aim of this study was to test the related motor performance by obtaining and analyzing
motor data from the test according to the standard "Three-phase Asynchronous Motor Test
Method (GB-T 1032-2012)". The performance of the tested motor has been evaluated to meet the
relevant requirements of the application. Thus, reasonable and scientific references have been offered
for the maintenance and repair of the motor.

Methods:
A three-phase AC asynchronous motor test system based on LabVIEW and an AC power
dynamometer was constructed based on the needs of the factory and type test of a three-phase AC
asynchronous motor. Ambient temperature measurement, insulation resistance measurement, DC
resistance measurement, no-load characteristics test, overspeed test, blocking characteristics test,
load test, and temperature rise test have been carried out. The data on voltage, current, speed, power,
and so on, have been collected. A 125 kW three-phase asynchronous motor was tested with the designed
system, and the parameters obtained from the system were compared with those from the
motor labels.

Results:
The three-phase AC asynchronous motor test system was designed based on LabVIEW and
AC dynamometer operating on an industrial computer with a precision measuring instrument. The
most advanced virtual instrument technology was used to combine the powerful data computing and
processing ability with the measurement and control ability of instrument hardware. The software
proved to be able to acquire data display, control, storage, and analysis simultaneously. In addition,
a high degree of intelligence, an automatic motor start and stop control, automatic synchronous acquisition
of test data, automatic data processing and calculation, and automatic test report generation
and printing function were covered in this system. The simulated results of the system agreed well with
the actual performance of the three-phase asynchronous motor, and helped the motor to operate well.

Conclusion:
The designed testing system exhibited a high automation ability, reliability, and accuracy.
It proved to be a time and manpower-saving technical method, improving the actual test efficiency,
and helped to reduce labor intensity dramatically.
Improved Two Stage Generative Adversarial Networks for Adversarial
Example Generation with Real Exposure
Authors: Goyal Priyanka , Singh Deepesh 
Published: June 2023

Introduction:
Deep neural networks due to their linear nature are sensitive to adversarial examples. They can easily be broken just by a small disturbance to the input data. Some of the existing methods to perform these kinds of attacks are pixel-level perturbation and spatial transformation of images.

Method:
These methods generate adversarial examples that can be fed to the network for wrong predictions. The drawback that comes with these methods is that they are really slow and computationally expensive. This research work performed a black box attack on the target model classifier by using the generative adversarial networks (GAN) to generate adversarial examples that can fool a classifier model to classify the images as wrong classes. The proposed method used a biased dataset that does not contain any data of the target label to train the first generator Gnorm of the first stage GAN, and after the first training has finished, the second stage generator Gadv, which is a new generator model that does not take random noise as input but the output of the first generator Gnorm.

Result:
The generated examples have been superimposed with the Gnorm output with a small constant, and then the superimposed data have been fed to the target model classifier to calculate the loss. Some additional losses have been included to constrain the generation from generating target examples.

Conclusion:
The proposed model has shown a better fidelity score, as evaluated using Fretchet inception distance score (FID), which was up to 42.43 in the first stage and up to 105.65 in the second stage with the attack success rate of up to 99.13%.
Performance Challenges and Solutions in Big Data Platform Hadoop
Authors: Singh Balraj , Verma Harsh K , Madaan Vishu 
Published: June 2023

Background:
The present era demands continuous support to bring improvements in
executing complex analytics on large-scale data and to work beyond traditional systems.

Objective:
The need for processing diverse data types and solutions for different domains of the
industry is rising. Such needs increase the requirement for sophisticated techniques and methods to
enhance the existing platforms and mechanisms further. It provides an opportunity for the research
community to investigate further into the existing systems, find potential issues, and propose new
ways to improve the current systems. Hadoop is a popular choice to manage and process Big data.
It is an open-source platform and a front-runner in the batch processing of large-scale jobs. The
economy associated with the cluster in scaling is low as compared to other platforms. However, this
popularity by no means guarantees high performance in all scenarios. With the continuous evolution
in data development and industrial requirements, it is imperative to investigate and look into
new methods and techniques to bring advancements to the existing system.

Method:
A systematic review is represented in this paper to have an insight into the current progress
in this field. Research publications from various sources are taken and analyzed. The performance
of a cluster largely depends upon the different job processing mechanisms and policies associated
with it.

Conclusion:
While extensive studies and solutions are proposed, the performance bottlenecks in
terms of load balancing, resource utilization, content management, and efficient processing prevail.
Not many of the solutions are there on scheduling about the trade-off between different parameters,
the process of content splitting and merging is not explored to a large extent and the skew mitigation
solutions are more focused on Reduce side of the MapReduce while the Map side is not utilized
much for load balancing.
Acceptance of Telemedicine Compared to In-Person Consultation From the Providers' and Users’ Perspectives: Multicenter, Cross-Sectional Study in Dermatology
Authors: Maul Lara Valeska , Jahn Anna Sophie , Pamplona Gustavo S P , Streit Markus , Gantenbein Lorena , Müller Simon , Nielsen Mia-Louise , Greis Christian , Navarini Alexander A , Maul Julia-Tatjana 
Published: June 2023

Background
Teledermatology is currently finding its place in modern health care worldwide as a rapidly evolving field.

Objective
The aim of this study was to investigate the acceptance of teledermatology compared to in-person consultation from the perspective of patients and professionals.

Methods
This multicenter, cross-sectional pilot study was performed at secondary and tertiary referral centers of dermatology in Switzerland from August 2019 to January 2020. A customized questionnaire addressing demographics and educational data, experience with telemedicine, and presumed willingness to replace in-patient consultations with teledermatology was completed by dermatological patients, dermatologists, and health care workers in dermatology.

Results
Among a total of 664 participants, the ones with previous telemedicine experience (171/664, 25.8%) indicated a high level of overall experience with it (patients: 73/106, 68.9%, dermatologists: 6/8, 75.0%, and health care workers: 27/34, 79.4%). Patients, dermatologists, and health care workers were most likely willing to replace in-person consultations with teledermatology for minor health issues (353/512, 68.9%; 37/45, 82.2%; and 89/107, 83.2%, respectively). We observed a higher preference for telemedicine among individuals who have already used telemedicine (patients: P<.001, dermatologists: P=.03, and health care workers, P=.005), as well as among patients with higher educational levels (P=.003).

Conclusions
This study indicates that the preference for teledermatology has a high potential to increase over time since previous experience with telemedicine and a higher level of education were associated with a higher willingness to replace in-patient consultations with telemedicine. We assume that minor skin problems are the most promising issue in teledermatology. Our findings emphasize the need for dermatologists to be actively involved in the transition to teledermatology.

Trial Registration
ClinicalTrials.gov NCT04495036; https://classic.clinicaltrials.gov/ct2/show/NCT04495036
Pengembangan Bahan ajar transformasi geometri berbantuan website: Pendekatan Project-Based-Learning Mozaik Geometri
Authors: Satriawati Gusni , Kholis Nur , Dwirahayu Gelar , Sobiruddin Dindin 
Published: June 2023

The digital era positively impacts all aspects of life, including education. Current learning requires teachers to use technology. Technology in learning mathematics is needed, especially in geometry material. The basic concept in geometry is the ability to visualize. An excellent understanding of visualization will help students understand geometric concepts. This study aims to develop teaching materials for geometry transformation material assisted by a website with a project-based learning approach using a geometric mosaic model that the eligibility criteria for teaching materials; therefore, it can be used in teaching and learning. Research and development with the ADDIE model are conducted in this study, which consists of phases: Analysis, Design, Development, Implementation, and Evaluation. The instruments used were expert/practitioner content validation sheets and student construct validation sheets; the instrument was developed using seven aspects. Teaching materials are validated by experts and also assessed by students. Based on the results of the assessment of 7 experts/experts, it was shown that the geometry transformation teaching material obtained very appropriate criteria with an assessment percentage of 85%. In contrast, the assessment of 28 Al Hasra Depok High School students showed good criteria with an assessment percentage value of 80%. Therefore, researchers can recommend website-assisted geometry transformation teaching materials using a project-based learning approach, "geometry mosaic," which can complement existing teaching materials and be used in mathematics learning activities, especially at the high school level.
KESALAHAN BERBAHASA PADA PENULISAN POSTINGAN DI MEDIA SOSIAL INSTAGRAM
Authors: Noviana Sinta , Atiqa Sabardila  
Published: June 2023

Artikel ini bertujuan untuk mengidentifikasi kesalahan berbahasa pada postingan Instagram. Sumber data dalam penelitian ini yaitu postingan dalam media sosial Instagram. Data dalam artikel ini yaitu kata, frasa, dan kalimat yang terdapat dalam postingan di Instagram.Metode pengumpulan data yang digunakan adalah deskriptif kualitatif. Teknik yang digunakan dalam mengambil data yaitu dengan membaca dan mencatat dari apa yang telah ditemukan dalam postingan Instagram. Hasil dalam artikel ini yaitu kesalahan penggunaan ejaan dan tanda baca, morfologis, serta sintaksis. Kesalahan penggunaan ejaan dan tanda baca yang ditemukan yaitu kesalahan dalam penggunaan titik (.), koma (,), tanda hubung (-), huruf kapital, dan tanda tanya (?). Kesalahan pada bidang morfologis yang ditemukan yaitu penggunaan kata ulang, huruf kapital pada semua kata dan singkatan kata, tidak sesuai dengan PUEBI, penulisan kata, dan penulisan kata depan. Pada bidang sintaksis, kesalahan yang ditemukan yaitu penggunaan kata mubazir dan kalimat yang tidak jelas. Kesimpulan yang didapat yaitu dalam penulisan postingan dalam Instagram masih terdapat banyak kesalahan berbahasa.
Kata kunci: kesalahan berbahasa; media sosial; postingan Instagram
Changes in the Histological Appearance of White Fat in Young Rats as a Result of Different Exercise Intensities
Authors: Lesmana Ronny , Syifa Diandra , Pratiwi Yuni , Rosdianto Aziiz , Mukarromah Siti , Goenawan Hanna , Tessa Putri 
Published: June 2023

Sedentary lifestyle can cause the accumulation of energy reserves in the form of lipids in white adipose cells. Lifestyle modification by means of exercise is done to reduce fat reserves in white adipose tissue (WAT). This study aims to determine the effect of exercise in various intensities on the histological changes of white adipose cells. Research method exploratory with Federer formula to determine the number of samples carried out. Using 28 Wistar rats located at the Central Laboratory of Padjadjran University, Sumedang from May to June 2022. The data taken were the average diameter ± standard error (SEM) of the inguinal white adipose cells of the experimental rats. Data analysis using Microsoft Excel 2016 and SPSS v.28 software. Of the 28 samples studied, only 25 samples met the inclusion criteria. Group K is 0.15% (p = 0.024) greater than P2, and 0.25% (p 0.001) is greater than P3. The P1 group had a value of 0.17% (p = 0.025) greater than P3. Moderate and vigorous exercise can be used to reduce the size of white adipose cells. While low-intensity exercise is considered ineffective. Further research can be carried out to assess changes in white adipose cells based on exercise intensity from other sides besides their morphology.
Keywords: Histological, White Adipose Tissue, Exercise
PERKEMBANGAN PEMIKIRAN FIKIH IBNU HAZM DAN RELEVANSINYA DALAM KONTEKS KEKINIAN
Authors: Fadli Fadli 
Published: June 2023

Islam adalah agama paripurna yang mengatur segala aspek kehidupan manusia dalam rangka mewujudkan tugasnya sebagai khalifah di permukaan bumi. Aturan Islam telah tertuang dalam sumber yang telah Rasūlullāh SAW tinggalkan empat belas abad yang silam yaitu al-Qur’an dan hadith. Dengan menyebarnya para Sahabat ke berbagai daerah, sehingga melahirkan banyak cendikiawan muslim yang mereka merupakan muridnya para sahabat yang kemudian dikenal dengan tabi‘in. Masa ini disebutkan dalam sejarah berkisar antara tahun 41 H sampai awal abad ke II H. Pada masa ini banyak terjadi kontroversialisme. Konsekuensi lain dari kontroversialisme pemahaman adalah meluasnya ruang ikhtilaf pada periode ini.Dalam batas-batas tertentu, karena perbedaan teori, formulasi, keadaan dan kondisi masyarakat, mereka sering berbeda dalam satu masalah yang sama. Seiring berjalan waktu, muncul seorang cendikiawan muslim di Andalusia (Spanyol sekarang). Beliau adalah Ibnu Hazm al-Andalusī. Beliau adalah salah seorang pengikut madhhab Hanbalī akan tetapi beliau melakukan pengemabngan pendapat sendiri yang agak berbeda dengan imamnya, sehingga timbul pertanyaan, apa saja pendapat beliau dalam fikih dan landasan berpikirnya serta apa saja pemikirannya yang dianggap relevan dengan masa sekarang. Hasil pemikiran beliau merujuk langsung dari al-Qur’an dan hadith. Di antara hasil pemikiran beliau yang relevansi dengan konteks sekarang adalah beliau membolehkan kepemimpinan dan kesaksian wanita serta konsep muzara‘ah dalam sistim pertanian. Beliau melandaskan pendapatnya kepada praktek Aisyah r.a dan praktek yang dilakukan oleh Rasūlullāh SAW.
Leder: Estetiske læreprosesser i pedagogisk praksis
Authors: Johannessen Elisabeth Hovde , Krosshus Tone Cronblad , Illeris Helene , Frers Lars 
Published: June 2023

Vi ønsker med dette temanummere Estetiske læreprosesser i pedagogisk praksis å synliggjøre, artikulere, nyansere og presentere artikler som kan bidra med nye perspektiver og være med på å utvikle nye undervisningspraksiser.