bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolomic profiles and pathogenesis of nephrolithiasis
Authors: Kowalczyk Nicholas S. , Prochaska Megan L. , Worcester Elaine M. 
Published: August 2023

Purpose of review
Kidney stone disease is caused by supersaturation of urine with certain metabolites and minerals. The urine composition of stone formers has been measured to prevent stone recurrence, specifically calcium, uric acid, oxalate, ammonia, citrate. However, these minerals and metabolites have proven to be unreliable in predicting stone recurrence. Metabolomics using high throughput technologies in well defined patient cohorts can identify metabolites that may provide insight into the pathogenesis of stones as well as offer possibilities in therapeutics.

Recent findings
Techniques including 1H-NMR, and liquid chromatography paired with tandem mass spectroscopy have identified multiple possible metabolites involved in stone formation. Compared to formers of calcium oxalate stones, healthy controls had higher levels of hippuric acid as well as metabolites involved in caffeine metabolism. Both the gut and urine microbiome may contribute to the altered metabolome of stone formers.

Summary
Although metabolomics has offered several potential metabolites that may be protective against or promote stone formation, the mechanisms behind these metabolomic profiles and their clinical significance requires further investigation.
Regulation of the WNK4-SPAK-NCC pathway by the calcium-sensing receptor
Authors: Chávez-Canales María , García Janeth Alejandra , Gamba Gerardo 
Published: August 2023

Purpose of review
Regulation of the sodium chloride cotransporter (NCC) in the distal convoluted tubule (DCT) plays a crucial role in renal salt handling. The calcium-sensing receptor (CaSR) has been shown to activate NCC through the WNK4-SPAK pathway, which is independent of the Renin-Angiotensin-Aldosterone system. In this review, we examine new information about the mechanism of how the CaSR regulates NCC through the WNK4-SPAK pathway and its physiological and therapeutic implications.

Recent findings
The activation of CaSR in TALH cells during hypercalcemia inhibits NKCC2 and ROMK activity, reducing paracellular Ca2+ reabsorption but decreasing salt reabsorption. This pathway enables NaCl reabsorption in the DCT while promoting Ca2+ excretion. CaSR activation in the apical DCT stimulates a signaling pathway involving PKC, WNK4, and SPAK, which increases NCC activation to recover the NaCl not reabsorbed in TAHL. Glucose or fructose acting as calcimimetics enhance apical CaSR sensitivity, increasing NCC activity, which contribute to the mechanism of hypertension prevalence in diabetic patients or in those with high fructose consumption.

Summary
These findings reveal the importance of the CaSR-mediated activation of the WNK4-SPAK pathway in regulating salt and calcium homeostasis and its potential as a therapeutic target for hypertension and related diseases.
Using Texture Analysis of Neck Computed Tomography Images to Differentiate Primary Hyperparathyroidism From Normal Controls
Authors: Kawashima Yusuke , Fujita Akifumi , Buch Karen , Qureshi M. Mustafa , Li Baojun , Takumi Koji , Rai Aayushi , Chapman Margaret N. , Sakai Osamu 
Published: August 2023

Objective
To investigate the utility of texture analysis in detecting osseous changes associated with hyperparathyroidism on neck CT examinations compared with control patients and to explore the best regions in the head and neck to evaluate changes in the trabecular architecture secondary to hyperparathyroidism.

Methods
Patients with hyperparathyroidism who underwent a 4D CT of the neck with contrast were included in this study. Age-matched control patients with no history of hyperparathyroidism who underwent a contrast-enhanced neck CT were also included. Mandibular condyles, bilateral mandibular bodies, the body of the C4 vertebra, the manubrium of the sternum, and bilateral clavicular heads were selected for analysis, and oval-shaped regions of interest were manually placed. These segmented areas were imported into an in-house developed texture analysis program, and 41 texture analysis features were extracted. A mixed linear regression model was used to compare differences in the texture analysis features contoured at each of the osseous structures between patients with hyperparathyroidism and age-matched control patients.

Results
A total of 30 patients with hyperparathyroidism and 30 age-matched control patients were included in this study. Statistically significant differences in texture features between patients with hyperparathyroidism and control patients in all 8 investigated osseous regions. The sternum showed the greatest number of texture features with statistically significant differences between these groups.

Conclusions
Some CT texture features demonstrated statistically significant differences between patients with hyperparathyroidism and control patients. The results suggest that texture features may discriminate changes in the osseous architecture of the head and neck in patients with hyperparathyroidism.
Thoracic Complications of Liver-Directed Therapy and Interventions
Authors: Pham Kaylee H. , Stowell Justin T. , Grage Rolf A. , Sella David M. , LeGout Jordan D. , Paz-Fumagalli Ricardo , Rojas Carlos A. 
Published: August 2023

Abstract
Liver-directed percutaneous and endovascular therapies are effective methods to diagnose and treat various hepatic disorders and malignancies. Because of the close anatomic proximity of the liver to the right hemidiaphragm, pleura, and lung bases, complications can arise involving these structures. Although they are rare, awareness of intrathoracic complications associated with liver-directed therapies and their imaging features will ensure timely detection and management. We aim to review the clinical and imaging features of thoracic complications related to liver-directed therapy and interventions.
The Role of the Autonomic Nervous System in the Mediation of the Resolution of Suicidal Ideation With Electroconvulsive Therapy
Authors: McCall William V. , Thomas Alvin , Miller Brian J. , Rosenquist Peter B. 
Published: August 2023

Abstract
Longitudinal observational studies have shown a meaningful decrease in suicidal thinking and suicidal behavior after receipt of electroconvulsive therapy (ECT). The antisuicide effect of ECT may be related to success in the global relief of the presenting syndrome such as depressive or psychotic illness. However, it is possible that the antisuicide effect is specific to ECT per se, over and above the relief of the clinical syndrome. Electroconvulsive therapy is associated with many observable neurochemical and physiologic effects, and some of these may plausibly be specifically linked to an antisuicide effect. The phenomenon of physiologic hyperarousal has been named as a candidate mechanism driving the risk for suicide. Hyperarousal is associated with decreased neuropsychological executive function responsible for response inhibition and can lead to impulsive action. The level of arousal within the autonomic nervous system (ANS) can be assayed with the pupillary light reflex, electrodermal activity, or with heart rate variability (HRV). This article summarizes the literature on the effects of ECT on HRV 24 to 72 hours after a course of ECT and finds evidence for increases in HRV, which indicates lower levels of arousal in the ANS. This finding suggests that ECT-related reductions in ANS arousal, presumably with corresponding improvements in response inhibition, may be one mechanism whereby ECT reduces risk for suicide.
Combined, yet Separate: cocktails of carriers (not drugs) for α-particle therapy of solid tumors expressing moderate-to-low levels of targetable markers
Authors: Nair Rajiv Ranjit , Prasad Aprameya , Bhatavdekar Omkar , Sarkar Aira , Gabrielson Kathleen L. , Sofou Stavroula 
Published: August 2023

AbstractAlpha-particle radionuclide-antibody conjugates are being clinically evaluated against solid cancers expressing moderate levels of the targeted markers, with promising results. These findings are attributed to the high killing power of alpha-particles in spite of the expected decrease in antibody tumor uptake, that reduces tumor absorbed doses. However, when tumor absorbed doses are reduced, addressing the heterogeneities in delivery of alpha-particles within solid tumors (i.e. enabling uniform irradiation patterns) becomes critical: to maintain efficacy, the fewer alpha-particles delivered within tumors need to traverse/hit as many different cancer cells as possible. This proof-of-concept study describes an approach to complement the antibody- targeted radiotherapy by using a separate carrier to deliver a fraction of the injected radioactivity to tumor regions geographically different than those affected by the antibody; collectively, the two carriers should distribute the alpha-particle emitters, Actinium-225 in particular, more uniformly within tumors maintaining efficacy.MethodsWe monitored the extent(s) of tumor growth inhibition, onset delay of spontaneous metastases and/or survival on orthotopic MDA-MB-213 and MDA-MB-436 triple negative breast cancer mouse models and on an ectopic BxPC3 pancreatic cancer mouse model, treated systemically with the two separate carriers. Tumors were chosen to express different (but low) levels of HER1, utilized as a model antibody-targeted marker.ResultsIndependent of tumor origin and/or resistance to chemotherapy, the two separate carriers: (a) improved the ‘primary’ tumor growth inhibition, (b) eliminated the formation of spontaneous metastases, and/or (c) prolonged survival, at lower or comparable tumor delivered doses relative to the antibody alone, without noticeable off-target toxicities.ConclusionThis tumor-agnostic strategy is timely and could be used to enhance the efficacy of existing alpha-particle radionuclide-antibody treatments without increasing, possibly even reducing, the total administered radioactivity.
Multi-omic temporal landscape of plasma and synovial fluid-derived extracellular vesicles using an experimental model of equine osteoarthritis
Authors: Anderson James R , Johnson Emily , Jenkins Rosalind , Jacobsen Stine , Green Daniel , Walters Marie , Bundgaard Louise , Hausmans Bas A C , van den Akker Guus , Welting Tim J M , Chabronova Alzbeta , Kharaz Yalda A , Clarke Emily J , James Victoria , Peffers Mandy J 
Published: August 2023

AbstractExtracellular vesicles contribute to osteoarthritis pathogenesis through their release into joint tissues and synovial fluid. Limited studies have profiled extracellular vesicles in osteoarthritic biofluids, such as plasma and synovial fluid. Due to the potential involvement in osteoarthritis pathogenesis, synovial fluid-derived extracellular vesicles have the potential to be ‘direct’ biomarkers in the causal pathway of disease but also enable understanding of their role in disease progression.Utilizing a temporal model of early osteoarthritis, we defined the changes in matched synovial fluid and plasma-derived extracellular vesicle small non-coding RNA and protein cargo using small RNA sequencing and mass spectrometry proteomics. We explored the data with a multi-omic approach including time series clustering, factor analysis and gene enrichment interrogation. Chondrocyte signalling induced by temporal synovial fluid-derived extracellular vesicles derived from the model were analysed using luciferase-based transcription factor activity assays.Extracellular vesicle protein cargo appears to be more important during osteoarthritis progression than small non-coding RNA cargo. Cluster analysis revealed plasma-extracellular vesicles represented a time-dependant response to osteoarthritis induction, were principally derived from protein cargo and were associated with supramolecular complexes. Clusters for synovial fluid-derived extracellular vesicles were associated with an initial osteoarthritis response and represented immune/inflammatory pathways. Factor analysis revealed that plasma-derived extracellular vesicles correlated with day post induction and were primarily composed of proteins which may modulate lipid metabolism in osteoarthritis. Synovial fluid-derived extracellular vesicles significant factors represented intermediate filament and supramolecular complexes reflecting tissue repair responses to osteoarthritis induction. There was a significant interaction between time and osteoarthritis for cAMP response element, Nuclear factor-kappa B response element, serum response element and serum response factor response element reporters with a trend for osteoarthritis synovial fluid-derived EVs at later time points to have a more pronounced effect.Local and systemic osteoarthritis-associated changes in extracellular vesicle cargo profiles in thisin vivomodel provided a unique opportunity to understand their role in disease propagation and progression and may represent novel biomarkers to stage osteoarthritis.
The influence of board size and board independence on triple bottom line reporting
Authors: Tajuddin Ahmad Hakimi , Akter Shabiha , Mohd-Rashid Rasidah , Mehmood Waqas 
Published: August 2023

PurposeThe purpose of this study is to examine the associations between board size, board independence and triple bottom line (TBL) reporting. The TBL report consists of three components, namely, environmental, social and economic indices.Design/methodology/approachThis study’s sample consists of top 50 listed companies from the year 2017 to 2019 on Tadawul Stock Exchange. Ordinary least squares, quantile least squares and robust least squares are used to investigate the associations between board characteristics and TBL reporting, including its separate components.FindingsThe authors find a significant negative association between TBL reporting and board independence. Social bottom line is significantly and negatively related to board size and board independence. Results indicate that board independence negatively influences the TBL disclosure of companies. Therefore, companies are encouraged to embrace TBL reporting. This suggests that businesses should improve the quality of their reporting while ensuring that voluntary disclosures reflect an accurate and fair view in order to preserve a positive relationship with stakeholders.Originality/valueThe present study explains the evidence for the determinants of the TBL in Saudi Arabia.
Financing strategy of the capital-constrained supply chain under uncertainty: the impact of blockchain technology on the credit period
Authors: An Simin , Li Bo , Wang Minxue , Zheng Wei 
Published: August 2023

PurposeThis paper explores the effectiveness of using blockchain technology to solve financial constraints faced by small- and medium-sized suppliers in a capital-constrained supply chain.Design/methodology/approachTo characterize the impact of blockchain on credit period and enterprise credit level, the study formulates a newsvendor model to analyze a supply chain in which a financially constrained supplier sells products to a financially sound manufacturer, subject to uncertain demand. The study investigates three repayment methods: the benchmark case without blockchain and two blockchain-enabled cases with the hybrid repayment mode and single repayment mode (SRM), respectively. The study derives and compares the equilibria under each repayment method to characterize their impact.FindingsWhen the bank interest rate is low and the carbon cap is also low, choosing to implement blockchain technology leads to higher profitability for the manufacturer than not utilizing it. Within the framework of blockchain technology, when comparing the two repayment models, the manufacturer exhibits a preference for SRM. Furthermore, under specific conditions of the bank interest rate, blockchain technology can effectively facilitate consensus among supply chain members in terms of channel selection.Practical implicationsThe results derived in this paper provide novel managerial implications to the capital-constrained members in terms of pricing decisions and order quantity under demand uncertainty considering blockchain technology, which transfers the creditor's rights to the bank and shortens the collection time. In addition, blockchain technology enables efficient and intelligent collaborative development of supply chains, which can reduce carbon emissions during the transportation of goods.Originality/valueFew studies incorporate blockchain technology into supply chain finance, and this paper considers the credit period and capital's time value for a capital-constrained supplier facing the adoption of blockchain technology within a stochastic demand environment.
Exploring the role of innovation attributes on mobile payment adoption
Authors: Arli Denni , Bakpayev Marat 
Published: August 2023

PurposeConsumers worldwide are increasingly adopting mobile payments. However, despite its global popularity, this innovation did not diffuse among American consumers extensively. As of 2019, less than 30% of smartphone users in the USA engaged in mobile payments. The purpose of this paper is to investigate drivers of mobile payment adoption in the USA and to explore the mediating factors of consumers’ attitudes toward mobile payments.Design/methodology/approachData were collected through Amazon M-Turk in the USA with 222 final respondents. Participants received an incentive to participate in this study. The measurement and structural models were evaluated by the component-based partial least squares (PLS) approach using Smart-PLS 3 software.FindingsThe study shows several factors affecting consumers’ attitudes toward mobile payments. Specifically, relative advantage, compatibility, observability, perceived security and convenience influence attitudes toward mobile payments and, consequently, behavioral intent to use mobile payment technology. This investigation contributes to the ongoing inquiry on the adoption of mobile payment technology in the USA. It offers specific insights for managers on how to increase mobile payment adoption. The study establishes a modified diffusion of innovations (DOI) model of consumer attitudes toward the use of mobile payments.Research limitations/implicationsThe objective of this study is to focus mainly on consumers in the USA, and it limits the generalizability of this study.Originality/valueThis study contributes to the current research on mobile payment adoption. Based on theoretical considerations, the authors derived a research model specifying critical drivers of an individual’s intentions to use mobile payments. Specifically, we establish a modified DOI-based model of consumer attitudes towards mobile payments. It shows several contributing factors affecting consumers’ attitudes toward mobile payments. The paper has important managerial implications aimed at the increase of the diffusion of mobile payments in the USA.
Consensus study on factors influencing the academic entrepreneur in a middle-income country’s university enterprise
Authors: Farrell Alfred Austin , Ashton James , Mapanga Witness , Joffe Maureen , Chitha Nombulelo , Beksinska Mags , Chitha Wezile , Coovadia Ashraf , Cutland Clare L. , Drennan Robin L. , Kahn Kathleen , Koekemoer Lizette L. , Micklesfield Lisa K. , Miot Jacqui , Naidoo Julian , Papathanasopoulos Maria , Sive Warrick , Smit Jenni , Tollman Stephen M. , Veller Martin G. , Ware Lisa J. , Wing Jeffrey , Norris Shane A. 
Published: August 2023

Purpose
This study aims to ascertain the personal characteristics of a group of successful academic entrepreneurs in a South African university enterprise and the prevalent barriers and enablers to their entrepreneurial endeavour.

Design/methodology/approach
The authors used a Delphi process to identify and rank the characteristics, enablers, barriers and behaviours of entrepreneurial academics, with a Nominal Group Technique applied to establish challenges they encounter managing their enterprise and to propose solutions.

Findings
Perseverance, resilience and innovation are critical personal characteristics, while collaborative networks, efficient research infrastructure and established research competence are essential for success. The university’s support for entrepreneurship is a significant enabler, with unnecessary bureaucracy and poor access to project and general enterprise funding an impediment. Successful academic entrepreneurs have strong leadership, and effective management and communication skills.

Research limitations/implications
The main limitation is the small study participant group drawn from a single university enterprise, which complicates generalisability. The study supported the use of Krueger’s (2009) entrepreneurial intentions model for low- and middle-income country (LMIC) academic entrepreneur investigation but proposed the inclusion of mitigators to entrepreneurial activation to recognise contextual deficiencies and challenges.

Practical implications
Skills-deficient LMIC universities should extensively and directly support their entrepreneurial academics to overcome their contextual deficiencies and challenging environment.

Originality/value
This study contributes to addressing the paucity of academic entrepreneur research in LMIC contexts by identifying LMIC-specific factors that inhibit the entrepreneur’s movement from entrepreneurial intention to entrepreneurial action.
Extending the research frontiers of employee mental health through contextualisation: China as an example with implications for human resource management research and practice
Authors: Cooke Fang Lee , Xu Wenqiong 
Published: August 2023

PurposeImpoverished employee mental health is harmful to employees and organisational performance. There is emerging interest in employee mental health in the human resource management (HRM) field. The majority of these studies mainly focus on the organisational and individual levels from the psychological and managerial perspectives without considering the sectoral characteristics and societal context.Design/methodology/approachThis perspective paper draws on extant literature as well as 10 informal interviews with medical professionals, organisational leaders in the public sector, teachers and HR professionals to shed light on employee mental health research, practice and challenges in the Chinese context.FindingsThis paper reveals national, sectoral, occupational and individual factors that shape mental health problems, individual coping mechanisms and organisational interventions. It also shows international influence on employee mental health in the form of institutional pressure and knowledge transfer.Research limitations/implicationsThere is limited research on employee mental health and HRM in the Chinese context, which restricts the scope of discussion in this paper, but at the same time presents rich future research opportunities that may be relevant to other national settings.Practical implicationsManaging the mental health of the workforce is part of the mental health management of the population, which means a holistic approach to building a mental health eco-system needs to be adopted. The authors call for more research on employee mental health in the Chinese context to provide evidence to support policy development and organisational efforts to scale up mental health services at the national and organisational levels. The authors also provide practical recommendations for policymakers and employing organisations.Originality/valueThe authors present a multi-level and multi-factor overview related to employee mental health in the Chinese context. The authors argue for a resource-based and multi-stakeholder approach, which will help inform and improve mental health policy and practice. The authors present several avenues for future scholarship and research. The authors extend the research frontiers of employee mental health issues by calling for the inclusion of a broader range of theoretical lenses including institutional theory, cultural and spiritual perspective and critical sociology to understand more fully how employee mental health conditions may be undermined or improved.