bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proposal for Clinical Management of Nodules Diagnosed as Atypia of Undetermined Significance via Thyroid Fine‐Needle Aspiration Cytology in the Absence of Molecular Testing
Authors: Suzuki Ayana , Hirokawa Mitsuyoshi , Kawakami Makoto , Kudo Takumi , Miyauchi Akira , Akamizu Takashi 
Published: January 2025

ABSTRACTObjectiveMolecular testing is recommended for risk stratification of atypia of undetermined significance (AUS) nodules in the USA; however, it is not routinely performed in some countries owing to limited availability and affordability. Here, we propose a risk stratification algorithm for AUS nodules when molecular testing is unavailable.MethodsWe examined 304 (4.3%) AUS nodules among 7073 thyroid fine‐needle aspiration cytology specimens examined at Kuma Hospital from January 2020 to December 2020. Clinical data were obtained from the medical records of Kuma Hospital.ResultsAUS with nuclear atypia and AUS‐other each accounted for half of the total AUS nodules. The repeat aspiration rate was 19.7%; 61.7% of the nodules were reclassified as benign or malignant upon repeat aspiration. Resection rate and overall risk of malignancy (ROM) were 32.6% and 12.8%, respectively. Architectural atypia showed the lowest (1.1%) overall ROM in the AUS nodules. For AUS with nuclear atypia, nodules ≤ 10 mm in size showed significantly lower overall ROM than those of > 10 mm, and nodules with ultrasonographically low suspicion showed significantly lower overall ROM than those with intermediate to high suspicion. AUS nodules with atypical lymphoid cells, possible medullary thyroid carcinoma, or possible parathyroid lesion were confirmed using flow cytometry, biochemical testing using needle washout fluid or immunocytochemistry, respectively.ConclusionsOur proposed clinical management algorithm for each subdivision according to cytological findings, based on repeat aspiration rates, ROM, ultrasound findings and results of ancillary tests except for molecular testing, should be useful for the clinical management of AUS nodules.
Influence of host species and seasonal interactions on bacterial community structure in fungus‐growing termites: Insights into symbiotic adaptation and ecological function
Authors: Jannual Nicharee , Kongthong Pornsinee , Kaewgrajang Tharnrat , Hasin Sasitorn , Nipitwattanaphon Mingkwan 
Published: January 2025

Abstract
Interactions between species and environmental factors play a key role in shaping ecological and evolutionary dynamics. Understanding these interactions provides insight into how they drive species adaptation and influence the structure of bacterial communities.
Fungus‐growing termites essentially have a symbiotic relationship with Termitomyces fungi. Termites grow fungus gardens in their nests in structures called fungus combs, where mycelia and nodules serve as a food source for termites geminated from the digestion of plant materials by termite workers. Bacteria also play a crucial role in cellulose degradation alongside fungal symbionts.
This study used 16S rRNA Illumina sequencing to explore the bacterial communities in fungus‐growing termites by considering multiple factors: termite species, sample types (gut, fungus comb), vegetative types and seasons.
Termite species emerged as the primary driver shaping these bacterial communities (16.7%). Additionally, interactions between termite species and season (8.7%) and between termite species and sample type (6.0%) significantly influenced the bacterial communities (p‐value <0.05).
Fifteen genera were identified as core microbiota, comprising over 50% of the total bacterial composition across all termite species. This dominance suggests that these core taxa play a vital role in the degradation processes that support the termite hosts.
Our study indicated the impact of ecological factors, such as seasonality, in shaping the bacterial community in fungus‐growing termites. Understanding these interactions is essential to uncover how bacterial communities adapt to changing environments and sustain the ecological balance within the termite ecosystem, offering broader insights into microbial ecology and host–microbe coevolution.
The evolving role of nursing informatics in the era of artificial intelligence
Authors: Nashwan Abdulqadir J. , Cabrega JC A. , Othman Mutaz I. , Khedr Mahmoud Abdelwahab , Osman Yasmine M. , El‐Ashry Ayman Mohamed , Naif Rami , Mousa Ahmad A. 
Published: January 2025

AbstractAimThis narrative review explores the integration of artificial intelligence (AI) into nursing informatics and examines its impact on nursing practice, healthcare delivery, education, and policy.BackgroundNursing informatics, which merges nursing science with information management and communication technologies, is crucial in modern healthcare. The emergence of AI presents opportunities to improve diagnostics, treatment, and healthcare resource management. However, integrating AI into nursing practice also brings challenges, including ethical concerns and the need for specialized training.Sources of evidenceA comprehensive literature search was conducted from January 2013 to December 2023 using databases like PubMed, Google Scholar, and Scopus. Articles were selected based on their relevance to AI's role in nursing informatics, particularly in enhancing patient care and healthcare efficiency.DiscussionAI significantly enhances nursing practice by improving diagnostic accuracy, optimizing care plans, and supporting resource allocation. However, its adoption raises ethical issues, such as data privacy concerns and biases within AI algorithms. Ensuring that nurses are adequately trained in AI technologies is essential for safe and effective integration.Implications for nursing practice and policyPolicymakers should promote AI literacy programs for healthcare professionals and develop ethical guidelines to govern the use of AI in healthcare. This will ensure that AI tools are implemented responsibly, protecting patient rights and enhancing healthcare outcomes.ConclusionAI offers promising advancements in nursing informatics, leading to more efficient patient care and improved decision‐making. Nonetheless, overcoming ethical challenges and ensuring AI literacy among nurses are critical steps for successful implementation.
Advancing Quality and Safety Culture in Healthcare: Insights From the Evaluation of an Improvement Science Program for Nurses and Midwives
Authors: Archer Yasmine , Chasle Briony , Macpherson Amanda , Wilson Val 
Published: January 2025

ABSTRACTAimsThis paper presents the outcomes and insights gained from the implementation of an Improvement Science program tailored for nursing and midwifery staff within a large local health district in New South Wales. The programme aimed to enhance frontline clinicians' confidence and capability in quality improvement, ultimately improving patient outcomes and safety culture.DesignThrough an explanatory sequential mixed‐methods evaluation study, we assessed the programme's effectiveness in building capacity, sustaining practice changes and fostering a culture of continuous improvement.MethodsQuantitative data were collected through pre‐post knowledge surveys, post workshop feedback and programme participation rates. Qualitative data were then collected via nine interviews with programme participants. Simple descriptive statistical analysis for quantitative data and a thematic analysis of qualitative data was undertaken. Data were then integrated from these multiple sources to gain a deeper understanding of the outcomes of the Improvement Science Program.ResultsKey findings indicate that coaching and mentoring support significantly contributed to project completion and sustained practice changes. Structured coaching sessions, collaborative team meetings, and executive sponsorship were vital components that facilitated successful outcomes. Notably, effective leadership, often demonstrated by Clinical Nurse Educators and Consultants, played a crucial role in fostering staff collaboration and participation. Insights from qualitative interviews highlight the transformative impact of the programme on participants' skills, confidence and practice.ConclusionThe paper concludes with recommendations for future Improvement Science programs, emphasising the importance of structured coaching, accountability mechanisms, and the identification and support of future coaches. Overall, this study underscores the value of ongoing training initiatives in promoting a culture of safety, quality improvement and enhanced patient outcomes in healthcare settings.Patient or Public ContributionThis study had no patient or public contribution.Reporting MethodAdherence to Standards for Reporting Qualitative Research (SRQR) EQUATOR guidelines (see ).
Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study
Authors: Tagami Kazuma , Iwama Noriyuki , Hamada Hirotaka , Tomita Hasumi , Kudo Rie , Kumagai Natsumi , Wang Hongxin , Izumi Seiya , Watanabe Zen , Ishikuro Mami , Obara Taku , Metoki Hirohito , Miura Yuichiro , Ota Chiharu , Sugiyama Takashi , Kuriyama Shinichi , Arima Takahiro , Yaegashi Nobuo , Saito Masatoshi ,   The Japan Environment and Children's Study Group
Published: January 2025

ABSTRACTAimsThis study investigated the association between maternal age and early and late gestational diabetes mellitus (GDM).MethodsIn total, 72,270 pregnant women were included in this prospective birth cohort study. Associations between maternal age and early GDM (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were evaluated using a multinomial logistic regression model with possible confounding factors. The reference category was maternal age of 30–34.9 years.ResultsHigher maternal age was associated with higher odds of early and late GDM (P‐value for trend <0.0001 and <0.0001, respectively). The adjusted odds ratios (aORs) for early GDM with maternal age of 35–39.9 years and ≥40 were 1.399 (95% confidence interval [CI]: 1.134–1.725) and 2.494 (95% CI: 1.828–3.402), respectively. The aORs for late GDM with maternal age of 35–39 years and ≥40 were 1.603 (95% CI: 1.384–1.857) and 2.276 (95% CI: 1.798–2.881), respectively.ConclusionsHigher maternal age was associated with an increased risk of GDM regardless of when GDM was diagnosed. The association between maternal age and early GDM was similar to that between maternal age and late GDM.
Transformative learning to politicized collective identity: How cisgender parents and caregivers of transgender and gender diverse youth become change makers for TGD justice
Authors: Kattari Leonardo 
Published: January 2025

AbstractThe aim of this article is to provide a theoretical application of transformative learning theory and politicized collective identity framework to examine the process cisgender parents and caregivers of transgender and gender diverse (TGD) children undergo to become advocates for TGD justice. With an intensifying anti‐TGD political climate and anti‐TGD rhetoric, this novel approach to understanding identity development through the lens of these two theories provides a timely and relevant framework for future research to explore motivators for participation in civic engagement for TGD justice among parents and caregivers.
Analysis of Immunometabolic Profiles in Patients With Chronic Drug‐Induced Liver Injury and Validation in Mice to Reveal Potential Mechanisms
Authors: Zhai Xingran , He Xian , Huang Ang , Liu Zherui , Chen Shaoting , Chang Binxia , Zhu Yun , Xie Huan , Bai Zhaofang , Xiao Xiaohe , Sun Ying , Wang Jiabo , Lu Yawen , Zou Zhengsheng 
Published: January 2025

ABSTRACTBackgroundThe mechanism underlying chronic drug‐induced liver injury (DILI) remains unclear. Immune activation is a common feature of DILI progression and is closely associated with metabolism. We explored the immunometabolic profile of chronic DILI and the potential mechanism of chronic DILI progression.MethodsPlasma and peripheral blood mononuclear cells from patients with chronic DILI were analyzed using multiplex immunoassays and untargeted metabolomics to reveal their immunometabolic profile. The effects and potential mechanisms of chronic DILI‐related metabolite on acute or chronic liver injury induced by LPS or CCl4 in mice were investigated.ResultsPatients with chronic DILI exhibited elevated plasma IL‐6, IL‐12p70, IL‐15 and reduced IL‐10 levels. The percentage of IL‐12+ monocytes was higher, while that of CD206+ monocytes, IL‐10+ monocytes, Th2, Treg, and IL‐10+ CD4+ T cells were lower in patients with chronic DILI compared to those with acute DILI. We identified the most significantly increased metabolite in patients with chronic DILI was cis‐aconitic acid (CAA). Administration of CAA can attenuate liver injury in mice with acute liver injury induced by LPS or CCl4 and promote the spontaneous resolution of liver fibrosis in mice with chronic live injury induced by CCl4. The protective mechanism of CAA against liver injury is associated with the inhibition of hepatic macrophage infiltration and polarization, which is achieved by inhibiting the secretion of neutrophil‐derived IL‐33 and subsequent phosphorylation of GATA3.ConclusionsCAA, which is elevated in patients with chronic DILI, protects against liver injury by inhibiting hepatic macrophage infiltration and polarization through the suppression of the IL‐33/GATA3 pathway, suggesting that CAA may serve as a potential target for regulating tissue repair in liver injury.
Associations Between Peak Expiratory Flow and Community Mobility Loss Among Older Adults in the United States
Authors: Mathis Lindsey M. , Sun Na , Ho Simon K. , White Lane S. , Addison Odessa , Savin Douglas N. , Falvey Jason R. 
Published: January 2025

ABSTRACTBackgroundCommunity mobility is a vital patient‐centered outcome for older adults living in the community. These deficits in mobility are linked to social isolation, increased hospitalizations, and higher mortality rates. Impaired pulmonary function may be a modifiable risk factor for mobility decline, with existing inequities in lung health potentially contributing disproportionately to mobility loss among Black older adults.Materials/MethodsA cohort of 4742 community‐dwelling older adults (weighted n = 29,180,893) with self‐reported ability to walk 3 or more blocks in their community was drawn from the National Health and Aging Trends Study (NHATS). Pulmonary function was measured by PEF in NHATS. Community mobility loss was defined as self‐reported inability to walk ≥ 3 blocks in the 1‐year follow‐up assessment. Hierarchical multivariable logistic regression was used and adjusted for demographics, comorbidities, pain, and assistive device use.ResultsOverall, 73.7% of the sample had normal PEF, 18.6% had moderate impairment, and 7.7% had severe impairment. Those with severe impairment were more likely to be male and identify as Black. In unadjusted analyses, 8.8% of older adults with normal PEF experienced mobility loss, compared with 12.7% of those with moderate impairment, and 19.7% with severe impairment. Odds of mobility loss were 111% higher for those with severe PEF impairment as compared to those with normal PEF (OR = 2.1, 95% CI 1.2–3.7) in fully adjusted models, with weaker relationships being observed for those with moderately impaired PEF (OR = 1.2, 95% CI 0.8–1.8).ConclusionsNearly 8%, or an estimated 1 million community‐ambulating U.S. older adults, had severe impairments in peak expiratory flow in 2015; these older adults have a substantially higher risk of losing the ability to ambulate community distances over the subsequent year.
Cognitive Trajectory Before and After Cataract Surgery: A Population‐Based Approach
Authors: Joo Hyundeok , Diaz‐Ramirez L. Grisell , Chen Catherine L. , Sun Catherine Q. , Smith Alexander K. , Boscardin W. John , Whitlock Elizabeth L. 
Published: January 2025

ABSTRACTBackgroundCataract surgery is the most common surgical procedure performed for older US adults. Cataracts are associated with poor cognition and higher rates of dementia, but whether cataract surgery improves cognition for US older adults is not known. We examined the relationship between cataract surgery and long‐term change in cognition in the Health and Retirement Study, a population‐based study of older US adults linked with Medicare billing data.MethodsWe analyzed community‐dwelling participants who underwent cataract surgery between 2000 and 2018, propensity‐matched on age, sex, education (four levels), diabetes status (four levels), pre‐procedural latent cognition, vision impairment, and interview timing and mode to older adults who did not have cataract surgery during the study period. Cataract surgery date was ascertained using Medicare billing data. We calculated latent value of cognition using biennial self/proxy cognitive assessments, and used linear mixed effects models adjusting for demographic and health factors to model cognition from 5 years before, to 5 years after, cataract surgery (or a simulated event, for controls). The primary measure was difference‐in‐differences estimate of latent cognition comparing the year prior, to the year after, cataract surgery or a simulated event.ResultsWe analyzed 4384 older adults who underwent cataract surgery and 4384 matched controls (mean [SD] age 76.1 [6.8] years, 62.0% women, 83.9% non‐Hispanic white). Across the first postoperative year, cataract surgical participants declined 0.002 (−0.002 to 0.006) units faster than nonsurgical controls (p = 0.37), equivalent to 8 (−10 to 26) days more cognitive aging. Post hoc subgroup analyses also found no difference in cognition for groups stratified by pre‐procedural latent cognition (i.e., normal vs. cognitively impaired) or vision (i.e., vision‐impaired vs. intact).ConclusionUnder typical United States practice, cataract surgery for older patients was not significantly associated with cognitive improvement or decline in the year after, compared with the year before, surgery.
The Role of Gli1+ Mesenchymal Stem Cells in Craniofacial Development and Disease Treatment
Authors: Li Wen , Jiang Han , Hu Longshuang , Shen Tianjiao , Chen Qianming 
Published: January 2025

ABSTRACTObjectiveThis review summarises the role of Gli1+ (Glioma‐associated oncogene homologue 1) mesenchymal stem cells in craniofacial growth and development or tissue repair, and their application in the treatment of some diseases.DesignThe search for this narrative review was conducted in PubMed and Web of Science using relevant keywords, including checking reference lists of journal articles by hand searching.ResultsGli1+ mesenchymal stem cells play an important role in the growth and development of the skull, tooth, periodontium and mandibular condyle. They can be applied to the treatment of pulp and periodontal diseases, temporomandibular joint osteoarthritis and other diseases.ConclusionsGli1+ mesenchymal stem cells are crucial for the development and repair of craniofacial tissue.
Inclusion of Black Soldier Fly Larval Oil in Ruminant Diets Influences Feed Consumption, Nutritional Digestibility, Ruminal Characteristics, and Methane Estimation in Thai‐Indigenous Steers
Authors: Prachumchai Rittikeard , Suntara Chanon , Kanakai Natdanai , Cherdthong Anusorn 
Published: January 2025

ABSTRACTThe objective of this study was to examine the impact of black soldier fly larval oil (BSFO) on feed consumption, nutritional digestibility, ruminal characteristics and methane (CH4) estimation in Thai‐indigenous steers. Four male Thai native steers (Bos indicus) weighing 383 ± 9.0 kg were used in this investigation. The experimental design employed was a 4 × 4 Latin square, involving four cattle assigned to four dietary treatments. These treatments included a basal diet (control group) and a concentrate diet containing varying levels of BSFO at 1%, 2% and 4% DM, respectively. Rice straw intakes, and total and nutritional intakes of organic matter (OM), ether extract (EE), neutral detergent fiber (and) and acid detergent fiber (ADF) decreased significantly and linearly with the amount of BSFO incorporated (p < 0.05). The digestibility of DM and OM changed quadratically (p < 0.05) across different BSFO inclusion doses, with the highest values of 65.6% and 69.0%, respectively. Furthermore, the addition of BSFO improved the EE digestibility (p < 0.05) when compared with the control group. The addition of various BSFO doses did not result in significant changes in ruminal pH, temperature, ammonia‐nitrogen (NH3‐N) levels or blood urea‐nitrogen (BUN) (p > 0.05). However, the introduction of increasing amounts of BSFO into the diet led to a reduction in protozoal populations (p < 0.01). When rumen fluid was sampled at 0 and 4 h after feeding, the 2% BSFO‐treated group had a greater propionic acid level (p < 0.05) than the no‐BSFO‐fed group. The CH4 estimate in the rumen of the steers exhibited notable variations among those administered different doses of BSFO (p < 0.05), with a linear decline observed as the oil dose increased. In conclusion, the inclusion of 2% BSFO in diets led to enhanced digestibility and higher propionic acid concentrations, along with reductions in protozoal population and CH4 emissions.
Better sleep hygiene is associated with better sleep health in mining shift workers in Australia
Authors: Beranek Philipp , Dunican Ian C. , Cruickshank Travis , Turner Mitchell 
Published: January 2025

SummaryAustralia's mine sites are largely situated in remote locations and operate around the clock. Many shift workers fly to site, where they work 12‐hr shifts and sleep in camp accommodation before they return home for the period rostered off work. Mining shift workers experience poor sleep, yet limited research is available on contributing factors. This study investigated, for the first time, the relationship between the sleep health and sleep hygiene in this population. A survey was disseminated to shift workers in the mining industry, utilising a cross‐sectional study design. The Sleep Health Index and Sleep Hygiene Index questionnaires were used to evaluate their sleep health and sleep hygiene, respectively. In total, 470 shift workers (mean age [years]: 39 ± 12, mean body mass index [kg m−2]: 28 ± 5) were included, which involved 132 females. Average scores for the Sleep Health Index and Sleep Hygiene Index were 76 ± 15 and 30 ± 7, respectively. Better sleep health was observed in shift workers with better sleep hygiene (β = −0.52, SE = 0.09 [−0.71, −0.34], p < 0.001). Differences in Sleep Health Index scores were found for individual Sleep Hygiene Index items related to “sleep regularity”, “sleep environment”, “mental health” and “time in bed extension”. However, no differences in Sleep Health Index scores were found for items related to “caffeine, alcohol or nicotine consumption” or “exercise” close to bedtime and “bedtime activities” (p > 0.05 for all). These findings demonstrate a relationship between sleep hygiene and sleep health; therefore, it may be possible to improve the sleep of shift workers by improving their sleep hygiene.