bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 14-Year Longitudinal Analysis of Healthcare Expenditure on Dementia and Related Factors (DEMENCOST Study)
Authors: Inoriza José M. , Carreras Marc , Coderch Jordi , Turro-Garriga Oriol , Sáez Marc , Garre-Olmo Josep 
Published: July 2023

Background: The large number of dementia cases produces a great pressure on health and social care services, which requires efficient planning to meet the needs of patients through infrastructure, equipment, and financial, technical, and personal resources adjusted to their demands. Dementia analysis requires studies with a very precise patient characterization of both the disease and comorbidities present, and long-term follow-up of patients in clinical aspects and patterns of resource utilization and costs generated. Objective: To describe and quantify direct healthcare expenditure and its evolution from three years before and up to ten years after the diagnosis of dementia, compared to a matched group without dementia. Methods: Retrospective cohort design with follow-up from 6 to 14 years. We studied 996 people with dementia (PwD) and 2,998 controls matched for age, sex, and comorbidity. This paper adopts the provider’s perspective as the perspective of analysis and refers to the costs actually incurred in providing the services. Aggregate costs and components per patient per year were calculated and modelled. Results: Total health expenditure increases in PwD from the year of diagnosis and in each of the following 7 years, but not thereafter. Health status and mortality are factors explaining the evolution of direct costs. Dementia alone is not a statistically significant factor in explaining differences between groups. Conclusion: The incremental direct cost of dementia may not be as high or as long as studies with relatively short follow-up suggest. Dementia would have an impact on increasing disease burden and mortality.
Phonological and Semantic Fluency in Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Authors: Olmos-Villaseñor Rocio , Sepulveda-Silva Consuelo , Julio-Ramos Teresa , Fuentes-Lopez Eduardo , Toloza-Ramirez David , Santibañez Rodrigo A. , Copland David A. , Mendez-Orellana Carolina 
Published: July 2023

Background: Semantic and Phonological fluency (SF and PF) are routinely evaluated in patients with Alzheimer’s disease (AD). There are disagreements in the literature regarding which fluency task is more affected while developing AD. Most studies focus on SF assessment, given its connection with the temporoparietal amnesic system. PF is less reported, it is related to working memory, which is also impaired in probable and diagnosed AD. Differentiating between performance on these tasks might be informative in early AD diagnosis, providing an accurate linguistic profile. Objective: Compare SF and PF performance in healthy volunteers, volunteers with probable AD, and patients with AD diagnosis, considering the heterogeneity of age, gender, and educational level variables. Methods: A total of 8 studies were included for meta-analysis, reaching a sample size of 1,270 individuals (568 patients diagnosed with AD, 340 with probable AD diagnosis, and 362 healthy volunteers). Results: The three groups consistently performed better on SF than PF. When progressing to a diagnosis of AD, we observed a significant difference in SF and PF performance across our 3 groups of interest ( p = 0.04). The age variable explained a proportion of this difference in task performance across the groups, and as age increases, both tasks equally worsen. Conclusion: The performance of SF and PF might play a differential role in early AD diagnosis. These tasks rely on partially different neural bases of language processing. They are thus worth exploring independently in diagnosing normal aging and its transition to pathological stages, including probable and diagnosed AD.
Association Between Neuroticism and Dementia on Healthcare Use: A Multi-Level Analysis Across 27 Countries from The Survey of Health, Ageing and Retirement in Europe (SHARE)
Authors: Ruiz-Adame Manuel , Ibañez Agustín , Mollayeva Tatyana , Trépel Dominic 
Published: July 2023

Background: People with high levels of neuroticism are greater users of health services. Similarly, people with dementia have a higher risk of hospitalization and medical visits. As a result, dementia and a high level of neuroticism increase healthcare use (HCU). However, how these joint factors impact the HCU at the population level is unknown. Similarly, no previous study has assessed the degree of generalization of such impacts, considering relevant variables including age, gender, socioeconomic, and country-level variability. Objective: To examine how neuroticism and dementia interact in the HCU. Methods: A cross-sectional study was performed on a sample of 76,561 people (2.4% with dementia) from 27 European countries and Israel. Data were analyzed with six steps multilevel non-binomial regression modeling, a statistical method that accounts for correlation in the data taken within the same participant. Results: Both dementia (Incidence Rate Ratio (IRR): 1.537; α= 0.000) and neuroticism (IRR: 1.122; α= 0.000) increased the HCU. The effect of having dementia and the level of neuroticism increased the HCU: around 53.67% for the case of having dementia, and 12.05% for each increment in the level of neuroticism. Conversely, high levels of neuroticism in dementia decreased HCU (IRR: 0.962; α= 0.073). These results remained robust when controlling for age, gender, socioeconomic, and country-levels effects. Conclusion: Contrary to previous findings, neuroticism trait in people with dementia decreases the HCU across sociodemographic, socioeconomic, and country heterogeneity. These results, which take into account this personality trait among people with dementia, are relevant for the planning of health and social services.
Incidence of Alzheimer’s Disease in Men with Late-Life Hypertension Is Ameliorated by FOXO3 Longevity Genotype
Authors: Chen Randi , Morris Brian J. , Donlon Timothy A. , Ross G. Webster , Kallianpur Kalpana J. , Allsopp Richard C. , Nakagawa Kazuma , Willcox Bradley J. , Masaki Kamal H. 
Published: July 2023

Background: It is well established that mid-life hypertension increases risk of dementia, whereas the association of late-life hypertension with dementia is unclear. Objective: To determine whether FOXO3 longevity-associated genotype influences the association between late-life hypertension and incident dementia. Methods: Subjects were 2,688 American men of Japanese ancestry (baseline age: 77.0±4.1 years, range 71–93 years) from the Kuakini Honolulu Heart Program. Status was known for FOXO3 rs2802292 genotype, hypertension, and diagnosis of incident dementia to 2012. Association of FOXO3 genotype with late-life hypertension and incident dementia, vascular dementia (VaD) and Alzheimer’s disease (AD) was assessed using Cox proportional hazards models. Results: During 21 years of follow-up, 725 men were diagnosed with all-cause dementia, 513 with AD, and 104 with VaD. A multivariable Cox model, adjusting for age, education, APOE ɛ4, and cardiovascular risk factors, showed late-life hypertension increased VaD risk only (HR = 1.71, 95% CI = 1.08–2.71, p = 0.022). We found no significant protective effect of FOXO3 longevity genotype on any type of dementia at the population level. However, in a full Cox model adjusting for age, education, APOE ɛ4, and other cardiovascular risk factors, there was a significant interaction effect of late-life hypertension and FOXO3 longevity genotype on incident AD ( β= –0.52, p = 0.0061). In men with FOXO3 rs2802292 longevity genotype ( TG/ GG), late-life hypertension showed protection against AD (HR = 0.72; 95% CI = 0.55–0.95, p = 0.021). The non-longevity genotype ( TT) (HR = 1.16; 95% CI = 0.90–1.51, p = 0.25) had no protective effect. Conclusion: This longitudinal study found late-life hypertension was associated with lower incident AD in subjects with FOXO3 genotype.
Designing and manufacturing custom-made 3D printed assistive devices: A comparison of three workflows
Authors: Slegers Karin , Delien Tessa , Bettelli Valentina , Lexis Monique , Saey Tom , Banes David , Daniëls Ramon 
Published: July 2023

BACKGROUND: Do-it-yourself technologies such as 3D printing offer interesting opportunities for creating custom-made assistive devices for people with disabilities. Although these opportunities are increasingly acknowledged, it remains unclear how 3D printing technology should be implemented in assistive devices delivery processes. OBJECTIVE: In three separate action research projects carried out in Belgium, Italy and The Netherlands, workflows were designed and evaluated that incorporate 3D printing as a standard option for providing clients with suitable assistive devices. METHODS: In this paper we describe and compare the three workflows that were conceived simultaneously, yet independently from each other. RESULTS: Based on the evaluations of these workflows, and the experiences of the researchers who developed the workflows, we provide recommendations for implementing 3D printing as a common approach in assistive device delivery processes in practice. Most importantly, designing and manufacturing should be done by means of a client-centered co-creation process by interdisciplinary teams of clinicians, clients, and 3D printing experts. We provide several recommendations for facilitating and supporting collaborations within such teams. CONCLUSIONS: The three workflows presented in this paper are strikingly similar and therefore provide a convincing starting point for interdisciplinary design teams who wish to embark on 3D printing custom-made assistive devices.
Híbridos de pimiento (Capsicum annuum L.)
Authors: Monge Perez José Eladio , Loría-Coto Michelle 
Published: July 2023

Objetivos: evaluar el rendimiento y la calidad de 11 híbridos de pimiento. Metodología: el ensayo se desarrolló en ambiente protegido, en Alajuela, Costa Rica. Se empleó fibra de coco como sustrato para las plantas, y el suministro de nutrientes fue mediante fertirrigación. Resultados: se halló una importante variabilidad en los datos obtenidos por los híbridos para la edad al inicio de cosecha (75 – 82 días luego de trasplante), cantidad de frutos de calidad primera (5.29 – 14.84frutos/m2), peso del fruto de calidad primera (173.20 – 238.10g), y rendimiento comercial (4.41 – 7.62kg/m2) y total (5.63 – 8.97kg/m2). Conclusiones: Los híbridos con la mayor cantidad de frutos de calidad primera fueron SEO-13 y SKX-31 (14.84 y 14.15frutos/m2, respectivamente). No hubo diferencias entre híbridos en el peso del fruto de calidad primera. Los híbridos con el mayor rendimiento comercial fueron SKX-31 (7.62kg/m2) y SEO-15 (7.17kg/m2), y esos resultados son superiores a los encontrados con los híbridos SKX-39, SEO-11 y SKX-36.
Sumber Daya Proyek Konstruksi Patimban Port Development Project yang Mempengaruhi Kinerja Kontraktor
Authors: Rohmah Khoirina Putri Izza , Sugandi R. Machmud , Alfianto Imam 
Published: July 2023

Construction project resources are one of the essential things in a construction phase. Every year, contractor performance decreases due to limitations in managing and managing project resources. One way contractors can deal with these problems is to improve quality performance during construction. One of the causes of problems at work is the resource factor. The resource factor in the construction process dramatically influences the contractor's performance. This study aims to analyze how much influence each factor of project resources (human resources, materials, equipment, implementation methods and information technology) of the project has Connecting Bridge, Patimban Port Development Project. The study collected sample data on 33 people involved in the project development process analysis using SEM-PLS analysis with the help of SmartPLS 3.0. From testing, this study's results indicate a positive and significant influence between the variables of human resources, materials, equipment amd implementation methods. This study's results obtained from the R square for the contractor performance variable were 0.809. It means that the percentage of human, material, equipment, implementation methods and information technology resources is 80.9%, while other factors influence the remaining 19.1%.
Healthcare professionals' satisfaction toward the use of district health information system and its associated factors in southwest Ethiopia: using the information system success model
Authors: Walle Agmasie Damtew , Demsash Addisalem Workie , Ferede Tigist Andargie , Wubante Sisay Maru 
Published: July 2023

BackgroundEthiopia has the potential to use the district health information system, which is a building block of the health system. Thus, it needs to assess the performance level of the system by identifying the satisfaction of end users. There is little evidence about users' satisfaction with using this system. As a result, this study was conducted to fill this gap by evaluating user satisfaction and associated factors of district health information system among healthcare providers in Ethiopia, using the information system success model.MethodsAn institutional-based cross-sectional study was conducted from November to December 2022 in the Oromia region of southwest Ethiopia. A total of 391 health professionals participated in the study. The study participants were selected using a census. Using a self-administered questionnaire, data were collected. Measurement and structural equation modeling analyses were used to evaluate reliability, the validity of model fit, and to test the relationship between the constructs, respectively, using analysis of moment structure (AMOS) V 26.ResultsSystem quality had a positive direct effect on the respondent's system use (β = 0.18, P-value &lt; 0.001), and satisfaction (β = 0.44, P-value &lt; 0.001). Service quality had also a direct effect on the respondent's system use (β = 0.37, P-value &lt; 0.01), and satisfaction with using the district health information system (β = 0.36, P-value &lt; 0.01). Similarly, system use had also a direct effect on the respondent's satisfaction (β = 0.53, P-value &lt; 0.05). Moreover, computer literacy had a direct effect on the respondent's system use (β = 0.63, P-value &lt; 0.05), and satisfaction (β = 0.51, P-value &lt; 0.01).ConcussionsThe overall user satisfaction with using the district health information system in Ethiopia was low. System quality, service quality, and computer literacy had a direct positive effect on system use and user satisfaction. In addition, system use and information quality had a direct positive effect on healthcare professionals' satisfaction with using the district health information system. The most important factor for enhancing system use and user satisfaction was computer literacy. Accordingly, for the specific user training required for the success of the district health information system in Ethiopia, the manager should offer additional basic computer courses for better use of the system.
GOLD stage-specific phenotyping of emphysema and airway disease using quantitative computed tomography
Authors: Konietzke Philip , Brunner Christian , Konietzke Marilisa , Wagner Willi Linus , Weinheimer Oliver , Heußel Claus Peter , Herth Felix J. F. , Trudzinski Franziska , Kauczor Hans-Ulrich , Wielpütz Mark Oliver 
Published: July 2023

BackgroundIn chronic obstructive pulmonary disease (COPD) abnormal lung function is related to emphysema and airway obstruction, but their relative contribution in each GOLD-stage is not fully understood. In this study, we used quantitative computed tomography (QCT) parameters for phenotyping of emphysema and airway abnormalities, and to investigate the relative contribution of QCT emphysema and airway parameters to airflow limitation specifically in each GOLD stage.MethodsNon-contrast computed tomography (CT) of 492 patients with COPD former GOLD 0 COPD and COPD stages GOLD 1–4 were evaluated using fully automated software for quantitative CT. Total lung volume (TLV), emphysema index (EI), mean lung density (MLD), and airway wall thickness (WT), total diameter (TD), lumen area (LA), and wall percentage (WP) were calculated for the entire lung, as well as for all lung lobes separately. Results from the 3rd-8th airway generation were aggregated (WT3-8, TD3-8, LA3-8, WP3-8). All subjects underwent whole-body plethysmography (FEV1%pred, VC, RV, TLC).ResultsEI was higher with increasing GOLD stages with 1.0 ± 1.8% in GOLD 0, 4.5 ± 9.9% in GOLD 1, 19.4 ± 15.8% in GOLD 2, 32.7 ± 13.4% in GOLD 3 and 41.4 ± 10.0% in GOLD 4 subjects (p &lt; 0.001). WP3-8 showed no essential differences between GOLD 0 and GOLD 1, tended to be higher in GOLD 2 with 52.4 ± 7.2%, and was lower in GOLD 4 with 50.6 ± 5.9% (p = 0.010 – p = 0.960). In the upper lobes WP3–8 showed no significant differences between the GOLD stages (p = 0.824), while in the lower lobes the lowest WP3-8 was found in GOLD 0/1 with 49.9 ± 6.5%, while higher values were detected in GOLD 2 with 51.9 ± 6.4% and in GOLD 3/4 with 51.0 ± 6.0% (p &lt; 0.05). In a multilinear regression analysis, the dependent variable FEV1%pred can be predicted by a combination of both the independent variables EI (p &lt; 0.001) and WP3–8 (p &lt; 0.001).ConclusionQCT parameters showed a significant increase of emphysema from GOLD 0–4 COPD. Airway changes showed a different spatial pattern with higher values of relative wall thickness in the lower lobes until GOLD 2 and subsequent lower values in GOLD3/4, whereas there were no significant differences in the upper lobes. Both, EI and WP5-8 are independently correlated with lung function decline.
Salt stress perception and metabolic regulation network analysis of a marine probiotic Meyerozyma guilliermondii GXDK6
Authors: Cai Xinghua , Sun Huijie , Yan Bing , Bai Huashan , Zhou Xing , Shen Peihong , Jiang Chengjian 
Published: July 2023

IntroductionExtremely salt-tolerant microorganisms play an important role in the development of functional metabolites or drug molecules.MethodsIn this work, the salt stress perception and metabolic regulation network of a marine probiotic Meyerozyma guilliermondii GXDK6 were investigated using integrative omics technology.ResultsResults indicated that GXDK6 could accept the salt stress signals from signal transduction proteins (e.g., phosphorelay intermediate protein YPD1), thereby contributing to regulating the differential expression of its relevant genes (e.g., CTT1, SOD) and proteins (e.g., catalase, superoxide dismutase) in response to salt stress, and increasing the salt-tolerant viability of GXDK6. Omics data also suggested that the transcription (e.g., SMD2), translation (e.g., MRPL1), and protein synthesis and processing (e.g., inner membrane protein OXA1) of upregulated RNAs may contribute to increasing the salt-tolerant survivability of GXDK6 by improving protein transport activity (e.g., Small nuclear ribonucleoprotein Sm D2), anti-apoptotic ability (e.g., 54S ribosomal protein L1), and antioxidant activity (e.g., superoxide dismutase). Moreover, up to 65.9% of the differentially expressed genes/proteins could stimulate GXDK6 to biosynthesize many salt tolerant-related metabolites (e.g., β-alanine, D-mannose) and drug molecules (e.g., deoxyspergualin, calcitriol), and were involved in the metabolic regulation of GXDK6 under high NaCl stress.DiscussionThis study provided new insights into the exploration of novel functional products and/or drugs from extremely salt-tolerant microorganisms.
Mapping gender stereotypes: a network analysis approach
Authors: Sánchez-Rodríguez Ángel , Moreno-Bella Eva , García-Sánchez Efraín 
Published: July 2023

IntroductionStereotypes have traditionally been considered as “mental pictures” of a particular social group. The current research aims to draw the structure of gender stereotypes and metastereotype schemes as complex systems of stereotypical features. Therefore, we analyze gender stereotypes as networks of interconnected characteristics.MethodThrough an online survey (N = 750), participants listed the common female and male features to build the structure of the gender stereotypes. Participants also listed the common features of how members of one gender think they are viewed by people of the other gender to build the structure of gender metastereotypes.ResultsOur results suggest that female stereotypes are characterized by a single community of features consistently associated such as intelligent, strong, and hardworkers. Female metastereotype, however, combines the previous community with another characterized by weak and sensitive. On the contrary, the male stereotype projected by women is characterized by a community of features associated such as intelligent, strong, and hardworker, but male in-group stereotypes and metastereotypes projected by men are a combination of this community with another one characterized by features associated such as strong, chauvinist, and aggressive.DiscussionA network approach to studying stereotypes provided insights into the meaning of certain traits when considered in combination with different traits. (e.g., strong-intelligent vs. strong-aggressive). Thus, focusing on central nodes can be critical to understanding and changing the structure of gender stereotypes.
The role of the ankle plantar flexor muscles in trip recovery during walking: a computational modeling study
Authors: Namayeshi Tayebeh , Haddara Raneem , Ackland David , Lee Peter Vee Sin 
Published: July 2023

BackgroundReactive lower limb muscle function during walking plays a role in balance, stability, and ultimately fall prevention. The objective of this study was to evaluate muscle and joint function used to regain balance after trip-based perturbations during walking.Research questionHow are lower limb muscles used to recover from external tripping during walking?MethodThe dominant legs of 20 healthy adult participants with similar athletic backgrounds were tripped using a split-belt instrumented treadmill. High- and medium-intensity trips were simulated by deceleration of the dominant leg at initial contact from the speed of 1.1 m/s to 0 m/s and back to 1.1 m/s in 0.4 s and 0.8 s, respectively. Lower limb kinematics, kinetics, and muscle forces following perturbations were computed to pre-perturbation values using statistical parametric mapping (SPM) paired t-test.ResultsA greater ankle dorsiflexion angle (mean difference: 5.3°), ankle plantar flexion moment (mean difference: 0.6Nm/kg), and gastrocnemius and soleus muscle forces (mean difference: 4.27N/kg and 13.56N/kg for GAS and SOL, respectively) were observed post-perturbation step despite the magnitude of the perturbation.SignificanceThis study concludes that adequate timely response of ankle function during a compensatory step is required for a successful recovery after tripping during walking in young healthy adults. Weakness in plantar flexors suggests insufficient ankle moments, which ultimately can result in falls. The findings of this paper can be used as a reference for the joint moments and range of motion needed to recover trips in the design of assistive devices. In addition to that, clinicians can use the estimated values of muscle forces and the pattern of muscle activities to design targeted training in fall prevention among the elderly.