bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPROVEMENT OF THE ORGANIZATIONAL AND ECONOMIC MECHANISM FOR THE DEVELOPMENT OF INVESTMENT ACTIVITIES IN THE AGRICULTURAL AND INDUSTRIAL COMPLEX OF SIBERIA
Authors: Tretyak Anna S. , Vaslavskaya Irina Yu. , Poltarykhin Andrey L. , Blagodatskaya Angelina A. 
Published: August 2023

The relevance of the work. The relevance of the study is due to the need to develop agro-industrial production at a new qualitative level, to increase the level of food security in the region by improving the organizational and economic mechanism for the development of investment activities in the agro-industrial complex.
Objective. The purpose of this study is the development of scientific and methodological provisions for improving the organizational and economic mechanisms of investment activity in the agro-industrial complex of Siberian regions.
Materials and methods. The research methodology is aimed at clarifying the basic principles of the formation of the organizational and economic mechanism for the development of the food and processing industry, taking into account the sectoral features of innovative development.
Results. In-depth studies were carried out on the organizations of the agro-industrial complex of the Novosibirsk region. The main part of the article discloses indicators characterizing the development of Russian agriculture in 2017-2020, as well as indicators of innovative activity in agriculture for 2017-2021. Shows the share of investments aimed at the reconstruction and modernization of fixed assets in Russia, as a percentage of the total investment. The mechanism of subsidizing to compensate for the costs incurred for the construction (modernization) of agribusiness facilities is considered. The main directions for improving the organizational and economic mechanism of the investment process in Siberian agriculture have been developed.
Conclusion. In conclusion, scientific provisions are formulated to improve the organizational and economic mechanism for the development of investment activities in the agro-industrial complex.
ORGANIC SUPPLY CHAIN MANAGEMENT PRODUCTS IN FOOD CLUSTERS: REGIONAL ASPECT
Authors: Voronkova Olga Yu. , Petrova Lyudmila I. , Mezhova Alexandra Yu. , Anufrieva Irina Yu. , Slukina Anna A. 
Published: August 2023

Background. A number of organizations interact in the supply chain of organic products - manufacturers, warehouses, distributors, carriers, wholesale and retail buyers involved in the formation of material, financial, information and service flows from the source of raw materials to the final consumer.
Purpose. It consists in the development of principles of supply chain management of organic products in the food system of the region
Materials and methods. The methodological and theoretical basis of the research was the work of domestic and foreign scientists on the management of the supply of organic products in regional food systems. In particular, for a practical example, the Altai Territory was chosen as an ecologically clean region with sufficient land, labor and production resources for the development of organic agricultural production and processing of organic products. In the course of the work, analytical, abstract-logical, monographic and other research methods were applied.
Results. It is advisable to manage the promotion of organic products in the food system of the region with the help of innovative digital technologies, in particular blockchain, as well as through the system of agricultural information and consulting centers, organization of presentations of organic products, advertising campaigns, participation in exhibitions and fairs at the regional and Russian levels, the opening of "green" shelves by retailers in their networks. The development of organic agriculture in the Altai Territory can have a significant positive effect on the level of economic, social and environmental development of rural areas of the region by activating the regional market of organic agricultural products, involving unused land resources in the production turnover, using innovative technologies in the agro-industrial complex, increasing the employment of rural residents, activating the ecotourism sphere, increasing the economic sustainability of agro-industrial organizations region.
Conclusion. The development of integrated solutions to these problems with the proper level of coordination of all participants in the supply chain of organic products contribute to the formation of a developing global market for organic raw materials and food, affecting agricultural production models, distribution of income and costs, the introduction of digital technology innovations, the greening of the agro-industrial sector, the development of the economy of agricultural regions.
CRP – a valuable source of information or just a laboratory test?
Authors: Leszcz Monika , Więckowska-Deroń Marta , Nitka Karolina , Białek Justyna , Ćwik-Błotnicka Dominika , Borczyk Joanna 
Published: August 2023

Background and Purpose: Laboratory tests are an inseparable element in modern medicine. They provide us with valuable clues for making a diagnosis or monitoring treatment. One of the most frequently ordered biochemical tests is the determination of the level of CRP in the blood. The aim of the study is to present the clinical usefulness of this study and to present knowledge about C-reactive protein.
Current state of knowledge: It is produced mainly by the liver, but the latest reports confirm local synthesis, among others, in arterial endothelial cells. The most common reason for the increase in the level of CRP is the appearance of infection, during which time its concentration may increase by up to 1000 times. Elderly patients have a weaker immune system response than younger patients, therefore the rise in CRP may be less pronounced. Other reasons are autoimmune diseases, cancer, or acute or chronic inflammation. As a result of cel damage, pro-inflammatory cytokines are secreted, which stimulate the production of CRP. Most scientific sources consider CRP ≥ 10 mg/L to be significant. Values of 3-10mg/L are considered a slight increase in CRP levels. Such CRP values were found in about 1/3 of the American population.
Conclusions: The CRP level should not be interpreted as an isolated medical parameter, but in conjunction with other tests and the patient's current state of health. Based on the amount of CRP in the blood and changes in its concentration over time, we can check the response to treatment and predict the course of some diseases.
New technologies in the surgical treatment of wounds
Authors: Symulewicz Michał , Korol Filip , Edyko Paweł , Jachowicz Krzysztof , Dobek Adam , Suwała Zuzanna , Minkner Mikołaj , Edyko Krzysztof , Bieńkowski Borys , Wójcik Bartłomiej 
Published: August 2023

Introduction: Many wounds are treated surgically. For many years the method itself consisted mainly in cleaning the wounds and bringing its edges closer together, either by strips for closing the wounds or by suturing the wound with classic sutures or staples. Recently, new methods have emerged to support wound healing, which are discussed in this article.
Materials and methods: The basis of the work were medical articles collected in the PubMed database. The research was conducted by analyzing key words such as: "surgical treatment of wounds", "new technologies in wounds", "wound healing and new technologies", "dressings in wound treatment", "new methods of accelerating wound healing".
Results: In the process of surgical wound treatment the basis is still the closure and connection of the edges of the wounds, which prevents infections, accelerates healing and improves the cosmetic effect. However this is not the final stage of wound healing. Equally important is the subsequent appropriate selection of the dressing - appropriate in terms of its composition of active substances and absorption properties. The choice of the right dressing has a large impact on the final effect and the avoidance of infections or the subsequent appearance of the scar. Now we also have many new technologies to help heal wounds. They help not only to reduce the risk of infection, but also accelerate the healing process and shorten the treatment time.
Evaluation of diagnostic and therapeutic procedures in patients with acute pancreatitis
Authors: Potyrała Piotr , Tomczak Wojciech , Kazzi Marcel , Winkler-Lach Weronika , Dorochowicz Mateusz , Pula Michal 
Published: August 2023

Introduction and purpose: Acute pancreatitis remains a clinically significant problem worldwide and in Poland, where its incidence is observed to be twice as high as in the global population. The aim of this study is to describe the latest available guidelines for managing patients diagnosed with acute pancreatitis, including diagnostic methods, radiological approaches, as well as conservative and invasive therapeutic treatment.

Materials and Methods: The literature available on PubMed, Scopus, Google Scholar databases, and guidelines from the Polish Society of Gastroenterology was reviewed using the words: „acute pancreatitis”, „pancreas", "AP treatment", and „acute pancreatitis management”.

Description of the state of knowledge: Patients with suspicion of acute pancreatitis are mainly diagnosed based on their symptoms using the Revised Atlanta Classification comprising of clinical symptoms, elevated pancreatic enzymes level, and imaging test results. The recommended therapeutic management for patients with acute pancreatitis underlines the importance of conservative treatment before the implementation of invasive procedures, the choice of which should be based on the severity and form of the condition.

Summary: The existing recommendations regarding the diagnostic approach in acute pancreatitis emphasize the importance of correlating symptoms with radiological findings obtained through ultrasound, which is a quick and widely accessible diagnostic tool. In therapeutic management, conservative treatment remains significant with the early implementation of nutritional support, along with the appropriate method and timing of surgical intervention depending on the form of acute pancreatitis and the presence of infection.
Sauna bathing and their properties – empirical research and awareness of people based on anonymous surveys
Authors: Wcisło Wojciech , Grużewska-Piotrowska Kinga , Pająk Monika , Hubka Joanna , Grużewska Agnieszka 
Published: August 2023

Introduction: Bathing at high temperatures has been a practice used for thousands of years in many cultures. High or low temperatures are considered a stress factor for the human body and are often a challenge to maintain homeostasis. Heat stress can be beneficial to human health, independent of other lifestyle factors.
The aim of the study: The aim of the study was to assess the level of knowledge among people about sauna bathing, the benefits of its use and diseases that are contraindications to such bathing, as well as empirical research on sauna bathing habits based on anonymous surveys.
Materials and methods: The research material was collected using an anonymous survey in May 2023. The obtained results were analyzed and verified on the basis of scientific literature and statistically processed using Microsoft Office Excel.
Results: 87.5% of the respondents use the sauna, the majority - several times a year, and 15% - several times a week. For 77.1% of respondents using the sauna, it is a form of entertainment, but 15.2% treat it as a form of health prevention. Many respondents wrongly indicate contraindications to bathing in the sauna, and 73.3% of people do not know any effects of the sauna.
Discussion and conclusions: Many respondents use the sauna, but most of them use it as a form of entertainment. Few people know the full effect of the sauna on the body and its multidirectionality. More than half of the respondents cannot name the contraindications to bathing in the sauna. As far as possible, the doctor should indicate people with, among others, increased cardiovascular risk, this form of prophylaxis.
Quality Differentiation and Matching Performance in Peer-to-Peer Markets: Evidence from Airbnb Plus
Authors: Wang Hongchang , Williams Benjamin , Xie Karen , Chen Wei 
Published: August 2023

Matching makes or breaks peer-to-peer (P2P) platforms. As the platform-based P2P markets shift from their grassroots nature toward elite offerings, will differentiating suppliers by quality increase matching performance? Can P2P markets differentiate certain suppliers without marginalizing others? We seek answers to these questions by leveraging an empirical opportunity on Airbnb, which differentiates listings that meet high quality standards from others through its Plus program in several U.S. cities. Our findings are threefold. First, we find a sizable increase in market-level matching performance after the program launch, that is, a 15.8%–16.2% increase in the number of booked nights. Second, the rise in matching performance is attributed to reduced search frictions, evident in markets with higher discovery and evaluation costs. Third, the Plus program benefits all listing tiers through reduced search frictions, yielding the most benefits to the Plus and non-Plus listings in terms of increased bookings and prices. Regular listings also receive increased bookings because of competitive prices. Our findings hold across multiple robustness checks and offer important insights for platform design and supply management in P2P markets. This paper was accepted by Hemant Bhargava, information systems. Supplemental Material: The web appendix and data are available at https://doi.org/10.1287/mnsc.2020.03920 .
Diversity of <em>Spa</em> gene between methicillin-resistant and methicillin-sensitive <em>Staphylococcus aureus</em> bacteria in a tertiary referral hospital, Indonesia
Authors: Amelia Sri , Kusumawati R. Lia , Balatif Ridwan , Tania Tryna , Winda Lavarina , Syamira Nadya Adlin 
Published: August 2023

BACKGROUND Spa typing is an effective and fast technique to identify the prevalence and spread of Staphylococcus aureus strains based on their spa gene profiles. The distribution of spa types will contribute to control the spread of S. aureus. Little is known regarding the spa types of S. aureus in Indonesia. This study aimed to investigate the diversity of spa gene among S. aureus carriage isolates in North Sumatra Province, Indonesia.
METHODS 79 S. aureus isolates consisting of 39 methicillin-resistant S. aureus (MRSA) and 40 methicillin-susceptible S. aureus (MSSA) carriage isolates were identified by VITEK2 Compact (Biomerieux, Indonesia) to detect mecA gene. All samples underwent spa typing and sequencing.
RESULTS Spa gene was detected among 31/39 (79%) of the MRSA isolates and 24/40 (60%) of the MSSA isolates. Most spa typing genes were identified between 350 and 400 base pair (bp). t258 and t852 were the most prevalence spa types among MRSA and MSSA isolates, respectively.
CONCLUSIONS Many MRSA and MSSA isolates encoded spa gene. The most genes detected were t258 and t852, identified in Germany and Portugal, respectively; while t18977 was initially identified in Malaysia. This indicated a global spread of MRSA according to spa typing.
Colorectal cancer disparities in Latin America: Mortality trends 1990–2019 and a paradox association with human development
Authors: Muzi Camila D. , Banegas Matthew P. , Guimarães Raphael M. 
Published: August 2023

Background
Colorectal cancer mortality is growing in Latin America. It is known for a marked income disparity between its countries, and there is a consistent association with development. Our purpose was to describe trends in colorectal cancer mortality in Latin America between 1990 and 2019, identifying differences by human development categories.

Methods
We extracted age-adjusted mortality rate from the Global Burden of Disease (GBD) Study from 22 Latin American countries, subregions, and country groups previously ranked by the GBD study due to Sociodemographic Index (SDI) between 1990 and 2019. We applied the segmented regression model to analyze the time trend. Also, we estimated the correlation between mortality rates and Human Development Index (HDI) categories for countries.

Results
Between 1990 and 2019, colorectal cancer adjusted mortality rate increased by 20.56% in Latin America (95% CI 19.75% - 21.25%). Between 1990 and 2004, the average annual percentage change (APC) was 0.11% per year (95% CI 0.10–0.12), and between 2004 and 2019 there was a deceleration (APC = 0.04% per year, 95% CI 0.03%– 0.05%). There is great heterogeneity among the countries of the region. Correlation between these two variables was 0.52 for 1990 and 2019. When separated into HDI groups, the correlation varied in the direction of the association and its magnitude, typifying an effect modification known as Simpson’s Paradox.

Conclusions
Human development factors may be important for assessing variation in cancer mortality on a global scale. Studies that assess the social and -economic contexts of countries are necessary for robust evaluation and provision of preventive, diagnostic and curative services to reduce cancer mortality in Latin America.
Association and progression of multi-morbidity with Chronic Kidney Disease stage 3a secondary to Type 2 Diabetes Mellitus, grouped by albuminuria status in the multi-ethnic population of Northwest London: A real-world study
Authors: Dattani Rakesh , Ul-Haq Zia , Shah Moulesh , Goldet Gabrielle , Darzi Lord Ara , Ashrafian Hutan , Kamalati Tahereh , Frankel Andrew H. , Tam Frederick W.K. 
Published: August 2023

Introduction
The prevalence of Diabetic Kidney Disease (DKD) secondary to Type 2 Diabetes Mellitus (T2DM) is rising worldwide. However, real-world data linking glomerular function and albuminuria to the degree of multi-morbidity is lacking. We thus utilised the Discover dataset, to determine this association.

Method
Patients with T2DM diagnosed prior to 1st January 2015 with no available biochemical evidence of CKD were included. Patients subsequently diagnosed and coded for CKD3a in 2015, were grouped by the degree of albuminuria. Baseline and 5-year co-morbidity was determined, as were prescribing practices with regards to prognostically beneficial medication.

Results
We identified 56,261 patients with T2DM, of which 1082 had CKD stage 3a diagnosed in 2015 (224-CKD3aA1,154-CKD3aA2,93-CKD3aA1; 611 patients with CKD3a but no uACR available in 2015 were excluded from follow up). No statistically significant difference was observed in the degree of co-morbidities at baseline. A significant difference in the degree of hypertension, retinopathy, ischaemic heart disease and vascular disease from baseline compared to study end point was observed for all 3 study groups. Comparing co-morbidities developed at study end point, highlighted a statistical difference between CKD3aA1 Vs CKD3aA3 for retinopathy alone and for hypertension and heart failure between CKD3aA2 Vs CKD3aA3. 40.8% of patients with CKD3aA2 or A3 were prescribed Renin Angiotensin Aldosterone inhibitors (RAASi) therapy between June-December 2021. Survival analysis showed 15% of patients with CKD3aA3 developed CKD stage 5 within 5 years of diagnosis.

Discussion
CKD3a secondary to DKD is associated with significant multimorbidity at baseline and 5 years post diagnosis, with CKD3aA3 most strongly associated with CKD progression to CKD 5, heart failure, hypertension and retinopathy compared to CKD3aA1 or CKD3aA2 at 5 years post diagnosis. The lack of uACR testing upon diagnosis and poor prescribing of RAASi, in those with CKD3aA2/A3, raises significant cause for concern.

Conclusion
DKD is associated with significant multimorbidity. Significant work is needed to be done to ensure patients undergo testing for uACR, to allow for future risk stratification and ability to be started on prognostically beneficial medication.
Predicting 5-year survival after kidney transplantation in Colombia using the survival benefit estimator tool
Authors: Nino-Torres Laura , García-Lopez Andrea , Patino-Jaramillo Nasly , Giron-Luque Fernando , Nino-Murcia Alejandro 
Published: August 2023

Introduction
A complex relationship between donor and recipient characteristics influences kidney transplant (KT) success. A tool developed by Bae S. et al. (Survival Benefit Estimator, SBE) helps estimate post-KT survival. We aim to evaluate the predictive performance of the SBE tool in terms of 5-year patient survival after a kidney transplant.

Methods
A retrospective cohort study of all deceased-donor KT recipients between January 2009 to December 2021. A descriptive analysis of clinical and sociodemographic characteristics was performed. The SBE online tool was used to calculate the predicted patient survival (PPS) and the survival benefit at five years post-KT. Comparisons between predictive vs. actual patient survival were made using quintile subgroups. Three Cox regression models were built using PPS, EPTS, and KDPI.

Results
A total of 1145 recipients were evaluated. Mortality occurred in 157 patients. Patient survival was 86.2%. Predictive survival for patients if they remained on the waiting list was 70.6%. The PPS was 89.3%, which results in a survival benefit (SB) of 18.7% for our population. Actual survival rates were lower than the predicted ones across all the quintiles. In unadjusted analysis, PPS was a significant protective factor for mortality (HR 0.66), whereas EPTS (HR 8.9) and KDPI (HR 3.25) scores were significant risk factors. The discrimination of KDPI, PPS, and EPTS scores models were 0.59, 0.65, and 0.66, respectively.

Conclusion
SBE score overestimated actual survival rates in our sample. The discrimination power of the score was moderate, although the utility of this tool may be limited in this specific population.
The cardiovascular polypill as baseline treatment improves lipid profile and blood pressure regardless of body mass index in patients with cardiovascular disease. The Bacus study
Authors: Chávez Fernández José Alejandro , Ramírez Mendoza Marcelo , Kassck Ipinaa Hermelinda , Sánchez Ángeles Luís Antonio , González Chávez Antonio , Escobedo Galileo , Méndez-García Lucía Angélica 
Published: August 2023

Background
Pharmacological treatment with lipid-lowering and antihypertensive drugs has been proposed as a strategy to improve excess cardiovascular (CV) risk among obese individuals. The present study aimed to assess whether the CV polypill (Sincronium®) could be an effective strategy to help improve CV risk factor control in obese/overweight individuals requiring secondary prevention.

Methods
This was an observational, retrospective study reviewing the hospital medical records of 479 patients with established CV disease who initiated treatment with the CV polypill between 2013 and 2019 at a general hospital in Mexico. Patients were grouped as normal weight, overweight or obese according to their initial body mass index (BMI). We collected blood pressure (BP), lipid profile, and vascular age at the last visit recorded during the period following treatment.

Results
At the end of the study, all assessed lipid parameters improved compared to baseline regardless of the initial BMI category (all p<0.001). There was an increase from baseline regarding the proportion of patients with at target low-density lipoprotein cholesterol after treatment (2.3% vs. 30.1%; p<0.001), more than 80% of patients achieved triglyceride levels <200 mg/dL (p<0.001), and more than 80% achieved target BP levels in all BMI subgroups (p<0.001). The subanalyses in the elderly population yielded similar results, with a significant overall improvement in lipid and BP control after initiating the CV polypill strategy.

Conclusions
The use of the CV polypill as baseline therapy for secondary prevention seems to be a reasonable strategy that enhances CV risk factor control regardless of the patient’s BMI.