bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of the clinical picture and severity of pain syndrome in girls with genital endometriosis on the background of conservative therapy of the disease in adolescence
Authors: Khashchenko E. P. , Pustynnikova M. Yu. , Kyurdzidi S. O. , Uvarova E. V. , Salnikova I. A. 
Published: January 2023

Introduction. Endometriosis is characterised by a chronic course and significantly affects the quality of life of young patients. Aim. To study the features of the clinical picture and pain syndrome in adolescent girls with genital endometriosis against the background of 1 year of therapy.Materials and methods. A prospective longitudinal study included 32 girls (14–17 years old) with a confirmed diagnosis of genital endometriosis. The clinical picture and severity of pain syndrome were assessed against the background of conservative therapy with NSAID (naproxen) to relieve dysmenorrhea and gestagen (dienogest) for 1 year.Results. The main complaint of girls with endometriosis was pain, which appeared on the day before menstruation or in the middle of the cycle since menarche (64%) or increased in 1–1.5 years after menarche (23%) to very intense pain (8.3 ± 1.6 V scale) of a tensive (44%) or clutching (25%) nature. One third of adolescents reported daily pain (24%), the majority (75%) complained of restricted daily activity and performance, gastrointestinal symptoms (44%) and dysuria (22%). After 1 year of treatment with gestagens and NSAIDs patients had a significant decrease in pain on the days of menstruation (p <0,001), as well as outside menstruation (p <0,001), frequency of restriction of daily activities (p <0,001), weakness, lowered working capacity on menstrual days (p < 0.001), gastrointestinal symptoms (p < 0.001) and urinary disorders (p < 0.001) and the need for mandatory pain medication (p < 0.001).Conclusion. A significant reduction in pain syndrome and clinical manifestations of dysmenorrhea against the background of an improved quality of life was observed in the adolescent patients during 1 year of conservative endometriosis therapy. No intensification or increase in the frequency of headache attacks or significant changes in BMI were observed in the study group, which is indicative of good tolerance and contributes to treatment adherence in young female patients.
Prediction of postpartum endometritis in women after vaginal birth
Authors: Zhilinkova N. G. , Apresyan S. V. , Apresyan S. S. 
Published: January 2023

Introduction. About 5 million postpartum infectious complications are recorded annually, and about 75 thousand of them lead to maternal death.Aim. To create predictive model founded on binary logistic regression which could help to diagnosis postpartum endometritis in women after vaginal delivery, based on analyses of links between anamnesis data, anthropometric indicators and risk of postpartum endometritis in postpartum women in modern mega policy.Material and methods. We conducted a retrospective cohort study, analysis of the 61 medical histories or the postpartum patient admitted to the gynecological department of a state medical institution in Moscow since 2019 to 2021 year was carried out with “Postpartum endometritis” and analysis of history of 70 birth history of postpartum women after physiological labor in different maternity hospital in Moscow.Results. Patient with postpartum endometritis statistically significant greater have overweight (р = 0,015), dental caries (р = 0,000), vaginitis (р = 0,000), first pregnancy (p = 0,025) and the next complications of pregnancy: acute respiratory viral infections (ARVI) (p = 0,010), urinary tract infections (p = 0,015), gestational diabetes (p = 0,013), inflammatory diseases of vagina and vulva (p = 0,008). They have statistically significant greater induction of labor (p = 0,000) and greater blood loss (p = 0,001).Conclusions. Predictive model is statistically significant, has 87,1% specifity and 86,9% sensitivity. It allows to prognose postpartum endometritis after vaginal birth.
Parents’ view on issues and problems of managing type 1 diabetes in children and adolescents in everyday life: results of the all-russian sociological survey “VOSHOD”
Authors: Saverskaya E. N. 
Published: January 2023

Introduction. Proper education of patients and their environment is essential in achieving compensation for type 1 diabetes mellitus (T1DM).Aim. Identifying problems in T1DM management in children and adolescents in daily life and assessing the needs for educational activities for children and parents.Materials and methods. A sociological survey with the participation of 508 parents of children and adolescents with T1DM was conducted in February-April 2022 in 7 federal districts of the Russian Federation. The electronic questionnaire contained 80 questions on various areas of disease management.Results. Age of children from 3 to 18 years (average 10.7 ± 3.64 g); gender of children female – 52.2% (265), male – 47.8% (243); T1DM experience – from 1 month to 15 years (average 3.9 ± 3.2 years). Parents face problems of glycemic variability in children (19.5%), difficulties in adjusting insulin dosages (14.4%), catering in schools/kindergartens (21.0%), preferential provision of insulins and medical devices for self-control of glycemia (17.1%), age characteristics of childhood and adolescence (14.9%), psychological problems (24.4%), indifference of medical workers (10.8%), difficulties of examination for glycated hemoglobin (36.3%); low physical activity of children (57.9%), lack of knowledge and skills of proper monitoring of glycemia during physical activity (46.6%), inaccessibility of sports (22.7%). Parents receive knowledge in schools of diabetes (37.6%), from endocrinologists (42.5%), dia chats in instant messengers (70.5%), social networks (59.6%), Internet resources (77.2%) are considered an important source of information. 91.3% of parents need constant replenishment of knowledge, they consider it important to educate children and form a responsible attitude towards their health.Conclusion. The current continuing education of patients with T1DM and their environment in the management of the disease in everyday life, the solution of issues of timely and full preferential provision of children and adolescents with T1DM medical devices for monitoring glycemia and insulin preparations will contribute to increasing the effectiveness of therapy, reducing the risk of complications and improving their quality of life.
Features of the pathology of the lymphoid ring of the pharynx in children during the COVID-19 pandemic
Authors: Andrianov A. V. , Drozdova M. V. , Preobrazhenskaya Yu. S. 
Published: January 2023

Introduction. For many years, one of the problems in medicine that attracted the attention of specialists from different areas of medicine was herpes virus infection. There are many reasons for this, including the often persistent nature of the course, a wide variety of clinical manifestations and routes of transmission, and many target organs of this infection. The disease can proceed in different ways, it has both asymptomatic, mild and rather severe course. For otorhinolaryngologists, Epstein-Barr virus (EBV), cytomegalovirus (CMV) and herpes virus 6 (HHV-6) are the most relevant and important in the context of the treated site of the pathological process. Since the end of 2020, humanity has faced a new, previously unexplored viral infection – a new coronavirus infection. And just like the previously studied herpes virus infection, COVID-19 has a large number of clinical manifestations and affects a huge number of organs and organ systems.Aim. To determine the types of interplay between COVID-19 and herpesviruses (EBV, CMV, HHV-6) in children of different ages with abnormalities of the lymphoid ring of pharynx.Materials and methods. In the course of the study, a comprehensive examination was carried out and the results of examination of children with pathology of the lymphoid ring of the pharynx who had herpes virus infection and COVID-19 were analyzed.Results. The results of the study obtained in the course of the work are consistent with the data that the virus carrier. The presence of an infectious agent triggers the production of macrophages and leads to clonal selection of T and B cells. Further, lymphocytes are transformed into lymphoblasts, which are capable of division and their transformation into plasma and B-memory cells occurs. As a result of this process, hypertrophy of the lymphoid tissue occurs and its reactive activity increases. (persistent herpesvirus infection) is one of the important causes of lymphoid proliferation in children. The combination of antigenic load and immaturity of the immune system in children is accompanied by an increase in the activity of lymphoid tissue and its compensatory activity.Conclusions. Past mild and asymptomatic COVID-19 can contribute to the reactivation of lymphotropic herpesviruses, first of all EBV, in 55-65% of children of preschool and school age.
Features of prediction of fatal and non-fatal cases of ischemic stroke in patients with peripheral atherosclerosis in the long-term period
Authors: Kobzeva N. D. , Martynov A. I. 
Published: January 2023

Introduction. According to official statistics, stroke ranks second in the structure of mortality in Russia after coronary heart disease. Mortality and morbidity rates from this pathology among people of working age have recently increased by more than 30%. It should be clarified that the main cause influencing the development of acute cerebrovascular accident is hemodynamically significant atherosclerosis of the carotid vessels. Moreover, the pathological process itself can progress rapidly, or, on the contrary, remain stable for a long time.Aim. To assess the features of the development of fatal and non-fatal cases of ischemic stroke and develop an optimal approach to its assessment in patients with peripheral atherosclerosis in the long-term period.Materials and methods. The study included a group of 519 patients with atherosclerotic lesions of various vascular beds. The average age of the examined patients was 60.0 ± 8.7 years.All persons underwent standard biochemical studies, a set of instrumental studies, in the presence of clinical manifestations that arouse suspicion of atherosclerotic lesions of the vascular pools, coronary angiography, angiography of the renal vessels, brachiocephalic arteries and arteries of the lower extremities were performed. The second stage of the work included a prospective follow-up of patients for three years with an assessment of the endpoints.Results. In the course of the statistical analysis, it was revealed that factors such as a history of amputation of the lower limb (p = 0.048), chronic ischemia of the lower extremities (p = 0.016), atherosclerosis of the abdominal aorta (p = 0.024) influenced the risk of developing non-fatal ischemic stroke in examined patientsConclusions. The complex analysis carried out made it possible to develop an original nomogram for assessing the risk of developing fatal and non-fatal cases of ischemic stroke in the long-term period, which can be used in real clinical practice.
Patterns and features of the course of the early and late stages recovery period after ischemic stroke associated with COVID-19
Authors: Kabaeva E. N. , Ershov A. V. , Litvitskiy P. F. , Rejepov D. T. , Pozdnyakov A. A. 
Published: January 2023

Introduction. COVID-19 increases the risk of ischemic stroke (IS), but the impact of COVID-19 on the recovery period of IS remains poorly understood.The aim of the study – to identify patterns and features of the course and manifestations of the early and late stages of the recovery period after ischemic stroke associated with COVID-19.Materials and methods. The combined retro-prospective study included 81 patients. Patients were divided into three groups: 1) development of stroke followed by outcome in ischemic stroke (IS) associated with COVID-19 (n = 21); 2) COVID-19 infection without stroke (n = 40); 3) development of stroke without COVID-19 (n = 20). All subjects were interviewed by telephone within 12 months from the date of discharge from the hospital. In patients with stroke, the severity of stroke (NIHSS scale), functional status (Rankine scale), and daily activity level (Bartel scale) were studied. All subjects were interviewed by telephone within 12 months from the moment of discharge from the hospital, the following were assessed: complaints, general condition of patients, the patient’s level of activity and ability to self-care, emotional status and the presence of anxiety and depressive disorders. The following were retrospectively assessed: stroke severity, functional status, volume of lung lesions according to MSCT, the presence of cardiovascular diseases, indicators of general and biochemical blood tests, changes in blood levels of cytokines IL-6, IL-8, IL-10, TNF-α.Results. The highest mortality at the post-hospital stage (only 67 and 47% of the total number of deaths) was in patients who had an ischemic stroke associated with COVID-19; half of them were registered in the first 3 months; by the end of the 6th month, this figure was 79%. Deaths in patients with IS due to COVID-19 occur 6 months earlier than in the group of patients with stroke without COVID-19. The leading causes of fatal outcomes in patients with IS due to COVID-19 in the first 3 months were acute myocardial infarction and repeated strokes. A high frequency of unfavorable rehabilitation prognoses and deaths both in the acute period of the disease and at the post-hospital stage was observed in patients with high comorbidity with forms of pathology of the circulatory system.Conclusion. Patients who have had an ischemic stroke associated with COVID-19, in the first 3 months of the post-hospital period, are at an increased risk of developing thrombotic complications and death and require special attention of outpatient doctors in this period after discharge from the hospital.
Nanostructured Lipid Carriers (NLCs) as Effective Drug Delivery
Systems: Methods of Preparation and their Therapeutic Applications
Authors: Alatawi Hind M. , Alhwiti Shemah S. , Alsharif Khwlah A. , Albalawi Shyma S. , Abusaleh Shroug M. , Sror Ghada K. , Qushawy Mona 
Published: January 2023

Abstract:
One of the drug delivery technologies is nanostructured lipid carriers (NLCs), which
improve drug permeability and thus bioavailability. NLCs are nanoparticles made from a lipid matrix
made up of a mixture of solid and liquid lipids. The inclusion of liquid lipids is useful in lowering
the ordered structure of solid lipids, increasing nanoparticle loading capacity, and drug entrapment
efficiency within NLCs. Hot homogenization, cold homogenization, micro-emulsion,
emulsification-solvent diffusion, high shear homogenization, and/or ultrasonication techniques,
double emulsion technique, melting dispersion method, membrane contractor technique, and
evaporation solvent injection are some of the methods that can be used to make NLCs. Both hydrophilic
and lipophilic medicines can be carried out by NLCs. They can deliver medications in a
variety of ways, including oral, topical, transdermal, parenteral, and ophthalmic. During the process
of preparing this review article, several distinct studies and patent reports about various
methods of NLCs formulations, their various therapeutic applications, and various routes of administration
were investigated and discussed. The study conducts an in-depth evaluation of the
most recent research publications and patents. NLCs have been utilized to treat a variety of disorders,
including cancer, fungal infections, bacterial infections, inflammation, liver diseases, and ocular
infections, due to their benefits. They can deliver medications to specific locations throughout
the body, allowing for drug targeting and a reduction in unwanted side effects. They can also be
used to improve bioavailability, reduce the medication's supplied dose, and improve the drug's
pharmacological activity.
Traditional Ayurvedic Treatment Practices by Vaidyas of the Northern Region
of India
Authors: Bhawana Mishra , Deepak Pant 
Published: January 2023

aims:
The aim of the present study was to investigate the current scenario of utilization and importance of medicinal plants used by traditional vaidyas. This study also provides the information about the thoughts of the younger generation toward Ayurveda knowledge and the explanation of the declining of traditional health care practices.

background:
Ayurvedic medicine is one of the oldest and traditional health care systems of India. There is limited documentation available regarding the information of traditional medicinal uses of plants while various rural folk and old aged peoples have long been using plants based formulation for curing human ailments. So, before such valuable knowledge becomes inaccessible and extinct, there is an urgent need to documenting this traditional knowledge to endorse the Ayurveda medicinal or Indigenous system.

objective:
Present study was carried out to profile the current scenario of medicinal plants used by Traditional vaidyas/oractitionera, lacals and status of Ayurveda and indigenous system in Northern states of India i.e. Haryana and Rajasthan.

method:
To know the current scenario of medicinal plants used by traditional Vaidyas in Northern states of India such as Haryana and Rajasthan, a survey was carried out among 50 vaidyas of each state, experiences of the local practitioners, inhabitants of Haryana, and Rajasthan states and scaltered literature. Information was gathered by a conversation with them and by filling the questionnaires of 20 questions regarding their knowledge, expertise, targeted ailments, herbal formulations, and preservation techniques.

result:
This survey highlighted the magic of Ayurveda and importance plants in medicinal usage which endorses the traditional vaidyas and their knowledge in Ayurveda Medicinal System. The attempts should be carried out to scientifically document all of the formulations prepared by these traditional Vaidyas, so that the disease can be eradicated from the root by traditional methods rather than heavy consumption of allopathic medicine. The high profile formulations might be prepared in future if most of the reputed traditional Vaidyas get organized.

conclusion:
This survey endorses the traditional vaidyas and their knowledge in Ayurveda Medicinal System as these traditions flourishing even today to treat and prevent illness. Also, an attempt might be done for the scientifically documentation of their formulations to eradicate chronic diseases from the root by traditional methods rather than heavy consumption of allopathic medicine. This step might be strengthen the validity of these products and provide a lead to target for new formulations preparations.

other:
This study also provides the information about the thoughts of the younger generation toward Ayurveda knowledge and the explanation of the declining of traditional health care practices.
Persuading Patients Using Rhetoric to Improve Artificial Intelligence Adoption: Experimental Study
Authors: Sebastian Glorin , George Amrita , Jackson Jr George 
Published: January 2023

Background
Artificial intelligence (AI) can transform health care processes with its increasing ability to translate complex structured and unstructured data into actionable clinical decisions. Although it has been established that AI is much more efficient than a clinician, the adoption rate has been slower in health care. Prior studies have pointed out that the lack of trust in AI, privacy concerns, degrees of customer innovativeness, and perceived novelty value influence AI adoption. With the promotion of AI products to patients, the role of rhetoric in influencing these factors has received scant attention.

Objective
The main objective of this study was to examine whether communication strategies (ethos, pathos, and logos) are more successful in overcoming factors that hinder AI product adoption among patients.

Methods
We conducted experiments in which we manipulated the communication strategy (ethos, pathos, and logos) in promotional ads for an AI product. We collected responses from 150 participants using Amazon Mechanical Turk. Participants were randomly exposed to a specific rhetoric-based advertisement during the experiments.

Results
Our results indicate that using communication strategies to promote an AI product affects users’ trust, customer innovativeness, and perceived novelty value, leading to improved product adoption. Pathos-laden promotions improve AI product adoption by nudging users’ trust (n=52; β=.532; P<.001) and perceived novelty value of the product (n=52; β=.517; P=.001). Similarly, ethos-laden promotions improve AI product adoption by nudging customer innovativeness (n=50; β=.465; P<.001). In addition, logos-laden promotions improve AI product adoption by alleviating trust issues (n=48; β=.657; P<.001).

Conclusions
Promoting AI products to patients using rhetoric-based advertisements can help overcome factors that hinder AI adoption by assuaging user concerns about using a new AI agent in their care process.
Adaptation of an Adult Web Application for Type 1 Diabetes Self-management to Youth Using the Behavior Change Wheel to Tailor the Needs of Health Care Transition: Qualitative Interview Study
Authors: Xie Li Feng , Housni Asmaa , Nakhla Meranda , Cianci Rosemarie , Leroux Catherine , Da Costa Deborah , Brazeau Anne-Sophie 
Published: January 2023

Background
Youth (aged 14-24 years) living with type 1 diabetes (T1D) encounter increased challenges in their diabetes self-management (DSM), especially during the transition to adult care. Although DSM education and support are imperative, there is insufficient information on how web-based digital tools tailored to their demands can be developed.

Objective
On the basis of the Behavior Change Wheel, this study aims to identify, among youth living with T1D, the needs and factors influencing their DSM in the context of health care transition and to inform the adaptation (content and features) of an adult self-guided web application (Support).

Methods
Internet-based semistructured individual interviews based on a phenomenological study design were conducted with 21 youths, and transcripts were analyzed using an inductive approach with concept mapping.

Results
Factors influencing T1D self-management were categorized into barriers and facilitators and then as external or internal. Features influencing the accessibility to information, increasing the sense of support, and use of the tool were positively accepted. Features unrelated to their expectations of digital tool use or difficulty navigating were viewed negatively. Participants expressed an interest in reliable, practical, and novel educational content. Although youth considered the information provided by medical professionals to be important, peer exchange was deemed necessary to obtain a practical perspective and real-life examples.

Conclusions
Compared with the adult population, in addition to tailored content and a simplified information search process, when building a DSM education and support digital tool for youth, features should be selected to encourage supervised peer exchange.