bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergetic Coupling of Redox‐Active Sites on Organic Electrode Material for Robust and High‐Performance Sodium‐Ion Storage
Authors: Yang Pan , Wu Zhenzhen , Wang Shouyue , Li Meng , Chen Hao , Qian Shangshu , Zheng Mengting , Wang Yun , Li Sheng , Qiu Jingxia , Zhang Shanqing 
Published: September 2023

AbstractOrganic electrode materials (OEMs), valued for their sustainability and structural tunability, have been attracting increasing attention for wide application in sodium‐ion batteries (SIBs) and other rechargeable batteries. However, most OEMs are plagued with insufficient specific capacity or poor cycling stability. Therefore, it′s imperative to enhance their specific capacity and cycling stability through molecular design. Herein, we designed and synthesized a heteroaromatic molecule 2,3,8,9,14,15‐hexanol hexaazatrinaphthalene (HATN‐6OH) by the synergetic coupling of catechol (the precursor of ortho‐quinone)/ortho‐quinone functional groups and HATN conjugated core structures. The abundance of catechol/ortho‐quinone and imine redox‐active moieties delivers a high specific capacity of nine‐electron transfer for SIBs. Most notably, the π–π interactions and intermolecular hydrogen bond forces among HATN‐6OH molecules secure the stable long‐term cycling performance of SIBs. Consequently, the as‐prepared HATN‐6OH electrode exhibited a high specific capacity (554 mAh g−1 at 0.1 A g−1), excellent rate capability (202 mAh g−1 at 10 A g−1), and stable long‐term cycling performance (73 % after 3000 cycles at 10 A g−1) in SIBs. Additionally, the nine‐electron transfer mechanism is confirmed by systematic density functional theory (DFT) calculation, attenuated total reflection Fourier transform infrared spectroscopy (ATR‐FTIR), and Raman analysis. The achievement of the synergetic coupling of the redox‐active sites on OEMs could be an important key to the enhancement of SIBs and other metal‐ion batteries.
Photoswitchable diarylethene‐based polyurethane film for photorewritable patterning and stable information storage
Authors: Yu Maolin , Wang Hong , Li Yuqi , Zhang Peisheng , Chen Shu , Zeng Rongjin , Gao Yong , Chen Jian 
Published: September 2023

ABSTRACTPhotoswitchable polymeric materials are promising candidates for rewritable patterning and optical information storage. However, traditional solid photoswitchable polymers are generally hampered by a low fatigue resistance and slow photoresponse. To overcome these two key deficiencies, in this study, we examined a simple synthetic strategy for producing photoswitchable polyurethane films via the covalent attachment of an excellent photochromic diarylethene. The as‐prepared diarylethene‐based polyurethane (DTE–PU) film showed rapidly reversible isomerization and splendid photoreversibility (>20 times). Additionally, the as‐prepared DTE–PU film in the closed form possessed outstanding thermal irreversibility and long‐term optical stability. Photowritten patterns on the DTE–PU film remained steady for more than 2 weeks. These eminent properties made the DTE–PU film a promising candidate for multifarious applications, including rewritable patterning and stable optical information storage. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47466.
Effectiveness of modified lignin on poly(butylene adipate‐co‐terephthalate)/poly(lactic acid) mulch film performance
Authors: Barros Janetty J. P. , Oliveira Rene R. , Luna Carlos B. B. , Wellen Renate M. R. , Moura Esperidiana A. B. 
Published: September 2023

AbstractIn this work, the biodegradable poly(butylene adipate‐co‐terephthalate) (PBAT)/poly(lactic acid) (PLA) blend (ECOVIO®) and lignin, a renewable and biodegradable natural polymer with high UV absorption and modified by gamma radiation were used to produce agriculture mulch films. Lignin was gamma‐irradiated at 30 and 60 kGy. The irradiated and non‐irradiated lignin content of 2 wt% was incorporated into PBAT/PLA blend matrix using a twin‐screw extruder and extrusion blown film to prepare flexible films. PBAT/PLA/LIGNIN films were characterized by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), x‐ray diffraction (XRD), field emission scanning electron microscopy (FESEM), tensile tests, contact angle, and UV–Vis analysis. FTIR spectra showed partial miscibility between PBAT/PLA and lignin, being intensified in irradiated lignin compounds. The DSC and XRD results confirmed that the degree of crystallinity of the blends was not significantly influenced by lignin addition. FE‐SEM images showed better dispersion and miscibility in PBAT/PLA/Irradiated lignin. Miscibility improvement provided by irradiated lignin promoted better mechanical properties, mainly with lignin irradiated at 60 kGy. PBAT/PLA/LIGNIN films containing 2 wt% showed excellent UV‐barrier property and greater hydrophobicity. Summing up, incorporation of low contents of irradiated lignin could be an interesting alternative to produce biodegradable UV‐blocking agriculture mulch films.
Potent inhibitors of tumor associated carbonic anhydrases endowed with cathepsin B inhibition
Authors: Kumar Amit , Arya Priyanka , Sharma Vikas , Giovannuzzi Simone , Raghav Neera , Supuran Claudiu T. , Sharma Pawan K. 
Published: September 2023

AbstractTwenty‐one novel extended analogs of acetazolamide were synthesized and screened in vitro for their inhibition efficacy against human carbonic anhydrase (hCA) isoforms I, II, IX, XII, and cathepsin B. The majority of the compounds were found to be effective inhibitors of tumor‐associated hCA IX and XII, and poor inhibitors of cytosolic hCA I. Despite the strong to moderate inhibition potential possessed by these compounds toward another cytosolic isoform hCA II, some of them demonstrated better potency against hCA IX and/or XII isoforms as compared to hCA II. Four compounds (11f, 11g, 12c, and 12g) effectively inhibited hCA IX and/or XII isoforms with considerable selectivity over the off‐targets hCA I and II. Interestingly, five compounds, including 11f, 11g, 12c, 12d, and 12g, inhibited hCA IX even better than the clinically used acetazolamide. Some of the novel synthesized compounds exhibited higher anti‐cathepsin B potential than acetazolamide, with % inhibition of around 50%, at a concentration of 10−7 M. Further, two compounds (12g and 12c) that showed effective and selective inhibition activity profiles against hCA IX and XII were additionally found to be effective inhibitors of cathepsin B.
Robust normalization and stabilization of descriptor fractional‐order systems with polytopic uncertainties in all matrices
Authors: Luo Siyou , Lu Jun‐Guo 
Published: September 2023

AbstractThis paper addresses the robust normalization and stabilization problems for descriptor fractional‐order systems with polytopic uncertainties in all system coefficient matrices, including the state derivative coefficient matrix. Firstly, novel sufficient conditions for the robust normality and stability of polytopic uncertain descriptor fractional‐order systems are presented based on linear matrix inequalities. Then, for the cases when the uncertain parameters are known and unknown, the proportional and derivative state feedback control with constant feedback gain and parameter‐dependent feedback gain are introduced to normalize and stabilize such systems, respectively. Finally, numerical examples are provided to show that the proposed approach is effective and less conservative than the results obtained by other researchers.
Calciumsulfatgebundene Deckschichten in Brettstapel‐Beton‐Verbunddecken
Authors: Imp Julian , Rempel Sergej , Mikoschek Michael 
Published: September 2023

AbstractAus ökologischer Motivation wurde die Holz‐Beton‐Verbundbauweise mit Kervenverbund optimiert, indem der herkömmliche Stahlbeton durch eine calciumsulfatgebundene Deckschicht und Bewehrung aus Basaltfasern substituiert wurde. In diesem Beitrag werden zunächst die grundlegenden Eigenschaften von Calciumsulfat als Bindemittel erläutert, gefolgt von experimentellen Bauteilversuchen, die das Trag‐ und Verformungsverhalten mittels Scher‐ und Biegeversuchen untersuchen und dabei einen Vergleich zu herkömmlichen Stahlbetondeckschichten ziehen. Als Ergebnis konnten vergleichbare Tragfähigkeiten und Steifigkeiten gegenüber Stahlbetondeckschichten erzielt werden. Langzeitbiegeversuche über einen Zeitraum von etwa zwei Jahren zeigten annähernd gleiche Durchbiegungen. Abschließend wird auf Besonderheiten in der baupraktischen Anwendung hingewiesen.
Bildbasierte Frischbetonprüfung
Authors: Schack Tobias , Coenen Max , Haist Michael 
Published: September 2023

AbstractHomogenität – d.h. die Gleichmäßigkeit der Zusammensetzung und Eigenschaften des Betons im frischen und festen Zustand – ist eine zentrale Anforderung an den Baustoff Beton. Variationen der Homogenität äußern sich in der Regel in lokalen Veränderungen z.B. des E‐Moduls, der Festigkeit oder Dauerhaftigkeit. Insbesondere bei hochfließfähigen (≥F5) und selbstverdichtenden Betonen (SVB), aber z.B. auch bei LP‐Betonen ist die Homogenität eine zeitabhängige Größe und ändert sich durch Entmischungsprozesse wie z.B. Sedimentation der groben Gesteinskörnung und Wasserabsonderung oder infolge einer ungeeigneten Verarbeitung. Eine Bewertung der Homogenität des frischen Betons ist mit den gegenwärtigen Prüfverfahren auf der Baustelle nur augenscheinlich möglich, da insbesondere die räumliche Verteilung der Betonausgangsstoffe (und damit die Homogenität) bislang nicht quantifiziert werden kann. Aufbauend auf den bereits in den ersten beiden Teilen dieses Beitrags vorgestellten bewertbaren Eigenschaften wird in diesem Beitrag das Eigenschaftsspektrum der bildbasierten Frischbetonprüfung um die Homogenität des Frischbetons erweitert. Dazu werden visuell erfassbare Eigenschaften des ausgebreiteten Frischbetons im Rahmen der Ausbreitmaßprüfung – Leimabsonderungen im Randbereich sowie geometrische Verteilung der Gesteinskörnung an der Oberfläche – herangezogen.
Using biomaterials to improve mesenchymal stem cell therapies for chronic, nonhealing wounds
Authors: Keshavarz Romina , Olsen Sara , Almeida Bethany 
Published: September 2023

AbstractHistorically, treatment of chronic, nonhealing wounds has focused on managing symptoms using biomaterial‐based wound dressings, which do not adequately address the underlying clinical issue. Mesenchymal stem cells (MSCs) are a promising cell‐based therapy for the treatment of chronic, nonhealing wounds, yet inherent cellular heterogeneity and susceptibility to death during injection limit their clinical use. Recently, researchers have begun to explore the synergistic effects of combined MSC‐biomaterial therapies, where the biomaterial serves as a scaffold to protect the MSCs and provides physiologically relevant physicochemical cues that can direct MSC immunomodulatory behavior. In this review, we highlight recent progress in this field with a focus on the most commonly used biomaterials, classified based on their source, including natural biomaterials, synthetic biomaterials, and the combination of natural and synthetic biomaterials. We also discuss current challenges regarding the clinical translation of these therapies, as well as a perspective on the future outlook of the field.
Pembrolizumab alone or in combination with chemotherapy versus chemotherapy for advanced gastric cancer: A cost‐effectiveness analysis
Authors: Lang Yitian , Lin Yan , Li Dan , Liu Jiyong , Liu Xiaoyan 
Published: September 2023

AbstractPurposeThe KEYNOTE‐062 trial demonstrated the efficacy and safety of pembrolizumab for advanced gastric cancer (GC). The current study evaluated the cost‐effectiveness of pembrolizumab alone or in combination with chemotherapy versus chemotherapy for advanced GC from the perspective of the United States and China. And the results will provide evidence and data support for more drug selection‐related decisions and research in the future.MethodsA partitioned survival approach with three states was created for treatment of advanced GC. The survival data were derived from KEYNOTE‐062 trial and the individual patient data were generated by a specific algorithm. We fitted 21 survival functions to each treatment arm and selected the most suitable distribution type for each one. Direct costs and utility values were collected from the published, available database. Cost, quality‐adjusted life‐years (QALYs), and incremental cost‐utility ratios (ICURs) were considered as the primary measure outcomes. One‐way and probabilistic sensitivity analyses were performed to assess the reliability of the analyses.ResultsIn the base‐case analysis of combined positive score (CPS) ≥1 patients, the ICUR of pembrolizumab plus chemotherapy versus chemotherapy in American and Chinese setting is $345,209/QALY and $186,802.6/QALY, respectively. And the ICUR of pembrolizumab versus chemotherapy is $473,650/QALY and $377,753/QALY in the context of the US and China, respectively. For CPS≥10 patients, the ICUR of pembrolizumab plus chemotherapy versus chemotherapy in American and Chinese setting is $483,742/QALY and $262,965/QALY, respectively. And that of pembrolizumab versus chemotherapy is $96,550/QALY and $67,896/QALY in the context of the US and China.ConclusionCompared with chemotherapy, either pembrolizumab plus chemotherapy or pembrolizumab monotherapy is not regarded as a cost‐effective strategy for patients with CPS≥1, advanced gastric cancer in the current American and Chinese setting. But pembrolizumab monotherapy for CPS≥10 patients would become a cost‐effective option in the American setting.
Long‐term outcomes of second‐line versus later‐line zanubrutinib treatment in patients with relapsed/refractory mantle cell lymphoma: An updated pooled analysis
Authors: Song Yuqin , Zhou Keshu , Zou Dehui , Li Dengju , Hu Jianda , Yang Haiyan , Zhang Huilai , Ji Jie , Xu Wei , Jin Jie , Lv Fangfang , Feng Ru , Gao Sujun , Zhou Daobin , Tam Constantine S. , Simpson David , Wang Michael , Phillips Tycel J. , Opat Stephen , Fang Cheng , Sun Shaohui , Zhu Jun 
Published: September 2023

AbstractBackgroundWe previously reported results of a pooled analysis of two zanubrutinib studies in relapsed or refractory (R/R) MCL showing better survival outcomes when zanubrutinib is used in second‐line versus later‐line. Here, we present an updated pooled analysis with a longer follow‐up of 35.2 months.MethodsData were pooled from two studies—BGB‐3111‐AU‐003 (NCT02343120) and BGB‐3111‐206 (NCT03206970) of zanubrutinib in R/R MCL. The patients were divided into two groups based on the treatment line of zanubrutinib: the second‐line and the later‐line group. The inverse propensity score weighting method was used to balance the baseline covariates between the groups. The primary outcome was overall survival (OS). Secondary outcomes included progression‐free survival (PFS), PFS, and OS rates, objective response rate (ORR), duration of response (DOR), and safety.ResultsAmong 112 pooled patients, 41 (36.6%) patients received zanubrutinib as second‐line and 71 (63.4%) patients as later‐line therapy. After weighting, OS was significantly improved in the second‐line versus later‐line group (HR, 0.459 [95% CI: 0.215, 0.98]; p = 0.044) with median OS not estimable in both groups. The PFS was similar between the two groups (HR, 0.78 [95% CI: 0.443, 1.373]; p = 0.389) but with numerically longer median PFS in the second‐line versus later‐line group (27.8 vs. 22.1 months). ORR was numerically higher in the second‐line versus later‐line (88.6% vs. 85.7%), and DOR was similar between the two groups (25.2 vs. 25.1 months). Zanubrutinib showed a similar safety profile in both groups.ConclusionZanubrutinib in second‐line treatment was associated with significantly improved OS compared with later‐line treatment of R/R MCL.
Association between adjuvant radiation treatment and breast cancer‐specific mortality among older women with comorbidity burden: A comparative effectiveness analysis of SEER‐MHOS
Authors: Lee Eunkyung , Hines Robert B. , Zhu Jianbin , Rovito Michael J. , Dharmarajan Kavita V. , Mazumdar Madhu 
Published: September 2023

AbstractBackgroundThe National Comprehensive Cancer Network suggested that older women with low‐risk breast cancer (LRBC; i.e., early‐stage, node‐negative, and estrogen receptor‐positive) could omit adjuvant radiation treatment (RT) after breast‐conserving surgery (BCS) if they were treated with hormone therapy. However, the association between RT omission and breast cancer‐specific mortality among older women with comorbidity is not fully known.Methods1105 older women (≥65 years) with LRBC in 1998–2012 were queried from the Surveillance, Epidemiology, and End Results–Medicare Health Outcomes Survey data resource and were followed up through July 2018. Latent class analysis was performed to identify comorbidity burden classes. A propensity score‐based inverse probability of treatment weighting (IPTW) was applied to Cox regression models to obtain subdistribution hazard ratios (HRs) and 95% CI for cancer‐specific mortality considering other causes of death as competing risks, overall and separately by comorbidity burden class.ResultsThree comorbidity burden (low, moderate, and high) groups were identified. A total of 318 deaths (47 cancer‐related) occurred. The IPTW‐adjusted Cox regression analysis showed that RT omission was not associated with short‐term, 5‐ and 10‐year cancer‐specific death (p = 0.202 and p = 0.536, respectively), regardless of comorbidity burden. However, RT omission could increase the risk of long‐term cancer‐specific death in women with low comorbidity burden (HR = 1.98, 95% CI = 1.17, 3.33), which warrants further study.ConclusionsOmission of RT after BCS is not associated with an increased risk of cancer‐specific death and is deemed a reasonable treatment option for older women with moderate to high comorbidity burden.
Demographics and access to head and neck cancer care in rural areas compared to urban areas in Germany
Authors: Vahl Julius M. , Nagel Gabriele , Grages Ayla , Brand Matthias , von Witzleben Adrian , Sonntag Michael , Theodoraki Marie‐Nicole , Greve Jens , Aboukors Tsima , Denkinger Michael , Dallmeier Dhayana , Idel Christian , Hoffmann Thomas K. , Laban Simon 
Published: September 2023

AbstractBackgroundDemographic development in rural and urban areas differs substantially. Demographics and access to specialized head and neck cancer centers may affect head and neck cancer patients' (HNCP) outcomes. Here, we compare epidemiological indicators and outcomes of HNCP in rural and urban Germany.Patients and MethodsIn a retrospective analysis of data from the Center for Cancer Registry Data (ZfKD) between 2002 and 2017, 212,920 HNCP were included. Incidence, demographics, travel distance to specialized centers, and ground values were compared between rural and urban areas with a focus on their association with patient outcomes.ResultsThe mean age of HNCP was significantly higher in urban areas (mean difference = 1.4 years; p < 0.0001), but increased at a comparable rate (p = 0.26) in rural and urban areas during the observation period. Gender imbalance was higher in rural areas (mean ratio of men/women: 4.1 vs. 3.1; p < 0.0001), but showed a comparable trend toward equilibration in both, rural and urban districts (p = 0.46). The portion of HNCP of the entire HNCP population living in urban areas increased from 55.9% in the year 2002 to 76.4% in the year 2017. There was no significant difference or change in the ratio of advanced to low UICC stage during the observation period (p = 0.26). However, travel distances to medical centers were higher in rural areas, especially (p < 0.0001) in East Germany. Median survival of HNCP in rural areas was significantly lower than in urban areas (42 months [SEM = 0.7; CI: 40.5–43.5] vs. 54 months [SEM = 1.2; CI: 51.7–56.3]; p < 0.0001) in East Germany, whereas in West Germany no significant difference was observed (59 months [SEM = 0.8; CI: 57.4–60.6] vs. 60 months [SEM = 0.5; CI: 59.0–61.0]; p = 0.15).ConclusionsPlace of residence contributes to survival outcome of HNCP. Access to specialized care and socioeconomic factors could be improved in East Germany.
Molecular and genetic bases of rice cooking and eating quality: An updated review
Authors: Bao Jinsong , Deng Bowen , Zhang Lin 
Published: September 2023

AbstractBackground and ObjectivesRice grain quality is a primary determinant of its market price and consumer acceptance. Although milling quality, appearance, cooking and eating quality (CEQ), and nutritional quality represent the main features of grain quality, rice CEQ is the most important feature in terms of price. Starch physicochemical properties and sensory evaluation have been widely applied to predict and assess rice CEQ. Understanding the genetic and molecular bases of CEQ formation will facilitate improvements in rice quality through a molecular breeding strategy.FindingsThe major genes responsible for rice CEQ formation have already been characterized in previous studies. Waxy (Wx) encoding granule‐bound starch synthase I (GBSSI) controls the apparent amylose content (AAC), starch synthase IIa (SSIIa) controls the gelatinization temperature, and fragrant gene (fgr) controls the aroma of cooked rice. Many natural variations (allelic variants) have been identified in these genes among rice germplasm. The protein content in rice grains is not only responsible for the nutritional quality but also CEQ. Two major genes that control the protein content have been identified and cloned. Pyramiding of different alleles by marker‐assisted selection and creation of new alleles by genome editing technology have facilitated improvements in new rice varieties with desirable CEQ.ConclusionsIn addition to presenting updates on the advances made in the important CEQ genes, we have identified some future challenges. These include the need to exploit new alleles in these genes, especially in Wx, to confer low AAC with a transparent appearance; identification of alleles in Wx that can improve the texture of cooked rice with high AAC and high‐resistant starch; formulation of methods to manipulate genes and modify agronomic practices to reduce the protein content to improve CEQ; and development of methods to breed climate‐smart rice with good, stable CEQ in changing environments.Significance and NoveltyThis article identifies some priorities for future research, which can enhance our understanding of the molecular basis of CEQ to improve this important rice quality attribute.