bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does herding effect help forecast market volatility?—Evidence from the Chinese stock market
Authors: Wang Yide , Yu Chao , Zhao Xujie 
Published: February 2023

AbstractThis paper aims to study the predictive power of market herding effect for market volatility. We extend the widely used four types of linear HAR models by incorporating the market herding index and further introduce a nonlinear forecasting mechanism by using two machine learning algorithms—support vector regression (SVR) and random forest (RF). All the methods are applied to the Chinese stock market. We evaluate their in‐sample and out‐of‐sample performances for various prediction step lengths. The results show that according to the RMSE and MAE, for the daily volatility prediction, the extra herding factor makes no significant contribution, and the linear model has no significant difference with the algorithms as well, whereas with the increase of step length, the herding factor shows a significant power in the weekly, monthly, and quarterly prediction, and meanwhile, the RF algorithm outperforms the other methods. However, for the QLIKE, the herding factor always significantly improves the predictions for all kinds of step lengths and methods, and the SVR algorithm with the herding factor is dominant. Overall, the herding factor helps forecast the volatility, and the extent to which the precision is improved takes on an inverted “U” shape with the increase in step length. The two algorithms are superior to the linear model, especially for the longer‐term prediction, and the herding factor can help enlarge this advantage, which implies a nonlinear relationship between the herding and volatility. Besides, the extra liquidity factor plays no significant role in the volatility prediction, but the continuous variation (CV), jump variation (JV), and leverage effect are helpful in most cases.
Studying the microbial, chemical, and sensory characteristics of shrimp coated with alginate sodium nanoparticles containing Zataria multiflora and Cuminum cyminum essential oils
Authors: Osanloo Mahmoud , Eskandari Zahra , Zarenezhad Elham , Qasemi Hajar , Nematollahi Amene 
Published: February 2023

AbstractRetardation of quality loss of seafood has been a new concept in recent years. This study's main objective was to evaluate the microbial, chemical, and sensory attributes of shrimp coated with alginate sodium nanoparticles containing Zataria multiflora and Cuminum cyminum essential oils (EOs) during refrigerated storage. At the end of storage time (15 days storage at 4°C), the pH, thiobarbituric acid reactive substances (TBARS), and total volatile basic nitrogen (TVBN) amounts in shrimps coated with the alginate nanoparticles were 7.62, 1.14 mg MDA/kg, and 117 mg/100 g which were significantly (p < .05) lower than the control groups. The count of all bacteria groups was also lower in this treatment, which was 2–2.74 Log CFU/mL on day 15 of cold storage. This combined treatment also obtained the highest sensory scores (around 7) and the lowest melanosis score (2.67) due to the effective delaying microbial and oxidation activities. Therefore, this edible coating could substantially retard microbial and chemical changes and improve the organoleptic properties of shrimp under refrigerated storage.
Transient receptor potential Ankyrin‐1 (TRPA1) agonists suppress myelination and induce demyelination in organotypic cortical slices
Authors: Giacco Vincenzo , Flower Grace , Artamonova Maria , Hunter Jake , Padilla Requerey Aitana , Hamilton Nicola B. 
Published: February 2023

AbstractOligodendrocytes are highly specialized glial cells characterized by their production of multilayer myelin sheaths that wrap axons to speed up action potential propagation. It is due to their specific role in supporting axons that impairment of myelin structure and function leads to debilitating symptoms in a wide range of degenerative diseases, including Multiple Sclerosis and Leukodystrophies. It is known that myelin damage can be receptor‐mediated and recently oligodendrocytes have been shown to express Ca2+‐permeable Transient Receptor Potential Ankyrin‐1 (TRPA1) channels, whose activation can result in myelin damage in ischemia. Here, we show, using organotypic cortical slice cultures, that TRPA1 activation, by TRPA1 agonists JT010 and Carvacrol for varying lengths of time, induces myelin damage. Although TRPA1 activation does not appear to affect oligodendrocyte progenitor cell number or proliferation, it prevents myelin formation and after myelination causes internodal shrinking and significant myelin degradation. This does not occur when the TRPA1 antagonist, A967079, is also applied. Of note is that when TRPA1 agonists are applied for either 24 h, 3 days or 7 days, axon integrity appears to be preserved while mature myelinated oligodendrocytes remain but with significantly shortened internodes. These results provide further evidence that TRPA1 inhibition could be protective in demyelination diseases and a promising therapy to prevent demyelination and promote remyelination.
Predictors of ibrutinib‐associated atrial fibrillation: 5‐year follow‐up of a prospective study
Authors: Mattiello Veronica , Barone Angelica , Giannarelli Diana , Noto Alessandro , Cecchi Nicola , Rampi Nicolò , Cassin Ramona , Reda Gianluigi 
Published: February 2023

AbstractIbrutinib‐associated atrial fibrillation (IRAF) emerged among the adverse events of major interests in ibrutinib‐treated patients as real‐world studies showed a higher incidence compared to clinical trials. We prospectively analyzed predictors of IRAF in 43 single‐center consecutive patients affected by chronic lymphocytic leukemia that started therapy with ibrutinib between 2015 and 2017. Key secondary endpoints were to describe the management of IRAF and survival outcomes. During a median follow‐up period of 52 months, we registered 45 CV events, with a total of 23 AF events in 13 patients (CI 30.0% (95% CI: 16.5–43.9)). Pre‐existent cardiovascular risk factors, in particular hypertension, a previous history of AF and a high Shanafelt risk score emerged as predictors of IRAF. Baseline echocardiographic evaluation of left atrial (LA) dimensions confirmed to predict IRAF occurrence and cut‐off values were identified in our cohort: 32 mm for LA diameter and 18 cm2 for LA area. No difference in progression free survival and overall survival emerged in patients experiencing IRAF. Following AF, anticoagulation was started in all eligible patients, and cardioactive therapy was accordingly modified. Echocardiography represents a highly reproducible and widespread tool to be included in the work‐up of ibrutinib candidates; the identification of IRAF predictors represents a useful guide to clinical practice.
Seasonal dynamics of canopy interception loss within a deciduous and a coniferous forest
Authors: Andreasen Mie , Christiansen Jesper R. , Sonnenborg Torben O. , Stisen Simon , Looms Majken C. 
Published: February 2023

AbstractCanopy interception loss is a key process in forest hydrology and the role of interception loss in relation to the forest water budgets and future impact of afforestation on water resources is important to quantify. Based on high frequency in situ monitoring, the effect of species‐ and leaf‐cover‐specific canopy structure metrics for interception loss estimation is examined at the two most typical forest types in Denmark. First, interception loss is estimated from precipitation and throughfall data collected in two even‐aged (40–60 years) temperate oak (deciduous) and Norway spruce (coniferous) forests over 13 and 11 months, respectively. Second, based on these observations we estimated canopy structure parameters relevant for interception loss; direct throughfall (ρ), the precipitation necessary to saturate the canopy (P'), the canopy evaporation as a fraction of precipitation (EC/P) and canopy storage capacity (S). Third, we compare observation‐based interception loss with predictions obtained by the analytical Gash interception model using the derived canopy structure parameters. Lastly, the effect of species‐ and leaf‐cover on the interception loss is quantified by applying the canopy structure parameters of the deciduous and coniferous forest on the same daily precipitation data set of approximately 1 year in the Gash model. We found that the derived canopy structure parameters reflect the seasonal change in the leaf cover of the deciduous forest and different parameters are identified for the two forest types. In the deciduous forest, improved agreement between observation‐based and predicted interception loss is obtained using canopy structure parameters for the leafless and full‐foliage periods instead of annual average values. The share of throughfall and interception loss to precipitation (total sum of precipitation = 526 mm) is 65% (340 mm) and 35% (186 mm) for the deciduous forest, respectively, and 49% (260 mm) and 51% (266 mm) for the coniferous forest, respectively. A seasonal variation of interception loss is observed in the deciduous forest where the share of interception loss to precipitation is 40% during the period with leaves on the trees (June to November) and 22% for the leafless periods (December to May). Thus, species‐ and leaf‐cover‐specific canopy structure metrics enhance model performance of throughfall and interception loss dynamics in forests.
Association of inflammatory bowel disease in first‐degree relatives with risk of colorectal cancer: A nationwide case‐control study in Sweden
Authors: Wang Kai , Olén Ola , Emilsson Louise , Khalili Hamed , Halfvarson Jonas , Song Mingyang , Ludvigsson Jonas F. 
Published: February 2023

AbstractThis study aims to assess the association between inflammatory bowel disease (IBD) history in first‐degree relatives (FDRs) and colorectal cancer (CRC) risk. We conducted a nationwide case‐control study in Sweden among 69 659 CRC cases and 343 032 non‐CRC controls matched on age, sex, birth year and residence county. Through linkage of multi‐generation register and the nationwide ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) cohort, we ascertained IBD diagnoses among parents, full siblings and offspring of the index individuals. Odds ratios (ORs) of CRC associated with IBD family history were calculated using conditional logistic regression. 2.2% of both CRC cases (1566/69659) and controls (7676/343027) had ≥1 FDR with IBD history. After adjusting for family history of CRC, we observed no increased risk of CRC in FDRs of IBD patients (OR, 0.96; 95%CI, 0.91‐1.02). The null association was consistent according to IBD subtype (Crohn's disease or ulcerative colitis), number of FDRs with IBD (1 or ≥ 2), age at first IBD diagnosis in FDRs (<18, 18‐39, 40‐59 or ≥60 years), maximum location/extent of IBD or FDR relation (parent, sibling or offspring). The null association remained for early‐onset CRC (diagnosed at age <50 years). In conclusion, IBD history in FDRs was not associated with an increased risk of CRC. Our findings suggest that extra screening for CRC may not be needed in the offspring, siblings or parents of IBD patients, and strengthen the theory that it is the actual inflammation or atypia of the colon in IBD patients that confers the increased CRC risk.
NADPH oxidase 4 regulate the glycolytic metabolic reprogramming of microglial cells to promote M1 polarization
Authors: Zhai Liping , Ruan Shuiliang , Wang Jin , Guan Qiaobing , Zha Li 
Published: February 2023

AbstractThis work aimed to investigate the role and mechanism of NADPH oxidase 4 (NOX4) in the polarization of microglial cells. Microglial cells were transfected with the NOX4 overexpression plasmid (pGL3‐NOX4), and later treated with lipopolysaccharide (LPS) and interferon‐γ (IFN‐γ) to induce its M1 polarization. Later, the F4/80 + CD86 + cell proportion was detected by flow cytometry (FCM), the inflammatory factor expression levels were analyzed through enzyme‐linked immunosorbent assay (ELISA), while ionized calcium binding adapter molecule 1 (IBA‐1) and PKM2 expression were measured by immunofluorescence (IF) staining. In addition, dichlorodihydrofluorescein diacetate probe was utilized to detect the reactive oxygen species (ROS) levels, glucose uptake, and glycolysis, as well as lactic acid level. The expression of glycolytic enzymes PKM2, HK2, and citrate (Si)‐synthas (CS) was detected by Western‐blot (WB) assay. Moreover, the polarization level of microglial cells was detected after ROS expression was suppressed by the ROS inhibitor N‐acetylcysteine (NAC). In mouse experiments, LPS was applied in inducing central neuroinflammation in NOX4 knockdown mouse model (KO) and wild‐type mice (WT). Thereafter, the inflammatory factor levels and lactic acid level in mouse tissues were detected; IBA‐1 and CD86 expression in mice was measured by IF staining; and the expression of glycolytic enzymes PKM2, HK2, and CS in the central nervous system (CNS) was also detected. After NOX4 overexpression in microglial cells, the M1 polarization level was upregulated, the F4/80 + CD86 + cell proportion increased, and inflammatory factors were upregulated. At the same time, the expression of glycolytic enzymes PKM2, HK2, and CS was upregulated. NAC pretreatment suppressed the effects of NOX4, reduced the F4/80 + CD86 + cell proportion, and suppressed the expression of PKM2, HK2, and CS. In the mouse model, the expression levels of CD86 in KO group decreased, and the inflammatory factors were also downregulated. NOX4 promotes glycolysis of microglial cells via ROS, thus accelerating M1 polarization and inflammatory factor expression. In this regard, NOX4 is promising as a new target for the treatment of neuroinflammation.
A nomogram prediction of citrate reaction during mononuclear cell collection in solid tumor patients
Authors: Xia Yong , Xue Hui , Li Jing , Yu Yanyan , Huang Wei , Zhou Chuchu , Shi Tingting , Cheng Yanxia , Zhang Caihong , Liu Shuang , Song Zongchang , Xu Sha , Lou Jinxing 
Published: February 2023

AbstractPurposeCitrate reaction is one of the main adverse events in peripheral blood mononuclear cell (MNC) collection. The aim of this study was to elucidate the risk factors for citrate reaction in patients with advanced solid tumor collection and to construct a nomogram to predict the risk.MethodsOne hundred forty‐eight patients with advanced solid tumor who underwent peripheral blood MNC collection in our hospital between January 2021 to December 2021 were selected. The general data, creatinine level before collection, Ca2+ concentration before collection, absolute value of monocyte lymphocytes before collection, circulating blood volume, anticoagulant dosage, and blood collection duration were included in Logistic regression analysis to identify the risk factors of citrate reaction. According to the results of the multivariate logistic model, nomogram was established and receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of the model.ResultsAmong the 148 solid tumor patients, 35 patients (23.6%) of the 148 patients developed citrate reaction. Multivariate analysis showed that the risk factors for citrate reaction in the process of collection included sex (odds ratio [OR] = 6.718; 95% confidence interval [95% CI]: 2.191‐20.594, P = .001), age (OR = 0.957; 95% CI: 0.921‐0.996, P = .03), and processed circulating blood volume (OR = 1.001; 95% CI: 1.000‐1.002, P = .01). Logistic regression can analyze independent risk factors and establish risk prediction model. The predictive performance of the model is good, and the area under ROC curve is 0.799.ConclusionsThe MNC collection process is safe. The incidence of citrate reaction in the collection of peripheral blood MNCs from patients with advanced solid tumor is related to the age, gender, and processed circulating blood volume of patients. The nomogram can be used to assess a patient's risk of citrate reaction.
How economic system justification shapes demand for peer‐to‐peer providers
Authors: Cakanlar Aylin , Ordabayeva Nailya 
Published: February 2023

AbstractWith the proliferation of peer‐to‐peer (P2P) exchanges in the marketplace, understanding which consumer factors drive demand for P2P providers is important. We examine the role of consumers' economic system justification (ESJ) beliefs (about the fairness of existing economic arrangements and outcomes), which, despite their growing salience in the marketplace, have been overlooked in extant P2P research. We show that high (vs. low) ESJ increases consumers' interest in purchasing from P2P providers because it heightens perceptions of these providers' entrepreneurial spirit. The effect emerges in the laboratory and in the field with measured and manipulated ESJ, and it is attenuated for traditional commercial providers. The findings offer novel insights and implications for practice and emerging research on P2P exchanges, system justification, and ideological consumption more broadly.
Molecular mechanisms of post‐burn muscle wasting and the therapeutic potential of physical exercise
Authors: Dombrecht Dorien , Van Daele Ulrike , Van Asbroeck Birgit , Schieffelers David , Guns Pieter‐Jan , Gebruers Nick , Meirte Jill , van Breda Eric 
Published: February 2023

AbstractAfter a severe burn injury, a systemic stress response activates metabolic and inflammatory derangements that, among other, leads to muscle mass loss (muscle wasting). These negative effects on skeletal muscle continue for several months or years and are aggravated by short‐term and long‐term disuse. The dynamic balance between muscle protein synthesis and muscle protein breakdown (proteolysis) is regulated by complex signalling pathways that leads to an overall negative protein balance in skeletal muscle after a burn injury. Research concerning these molecular mechanisms is still scarce and inconclusive, understanding of which, if any, molecular mechanisms contribute to muscle wasting is of fundamental importance in designing of therapeutic interventions for burn patients as well. This review not only summarizes our present knowledge of the molecular mechanisms that underpin muscle protein balance but also summarizes the effects of exercise on muscle wasting post‐burn as promising strategy to counteract the detrimental effects on skeletal muscle. Future research focusing on the pathways causing post‐burn muscle wasting and the different effects of exercise on them is needed to confirm this hypothesis and to lay the foundation of therapeutic strategies.
A compendium of single extracellular vesicle flow cytometry
Authors: Welsh Joshua A. , Arkesteijn Ger J. A. , Bremer Michel , Cimorelli Michael , Dignat‐George Françoise , Giebel Bernd , Görgens André , Hendrix An , Kuiper Martine , Lacroix Romaric , Lannigan Joanne , van Leeuwen Ton G. , Lozano‐Andrés Estefanía , Rao Shoaib , Robert Stéphane , de Rond Leonie , Tang Vera A. , Tertel Tobias , Yan Xiaomei , Wauben Marca H. M. , Nolan John P. , Jones Jennifer C. , Nieuwland Rienk , van der Pol Edwin 
Published: February 2023

AbstractFlow cytometry (FCM) offers a multiparametric technology capable of characterizing single extracellular vesicles (EVs). However, most flow cytometers are designed to detect cells, which are larger than EVs. Whereas cells exceed the background noise, signals originating from EVs partly overlap with the background noise, thereby making EVs more difficult to detect than cells. This technical mismatch together with complexity of EV‐containing fluids causes limitations and challenges with conducting, interpreting and reproducing EV FCM experiments. To address and overcome these challenges, researchers from the International Society for Extracellular Vesicles (ISEV), International Society for Advancement of Cytometry (ISAC), and the International Society on Thrombosis and Haemostasis (ISTH) joined forces and initiated the EV FCM working group.To improve the interpretation, reporting, and reproducibility of future EV FCM data, the EV FCM working group published an ISEV position manuscript outlining a framework of minimum information that should be reported about an FCM experiment on single EVs (MIFlowCyt‐EV). However, the framework contains limited background information. Therefore, the goal of this compendium is to provide the background information necessary to design and conduct reproducible EV FCM experiments. This compendium contains background information on EVs, the interaction between light and EVs, FCM hardware, experimental design and preanalytical procedures, sample preparation, assay controls, instrument data acquisition and calibration, EV characterization, and data reporting. Although this compendium focuses on EVs, many concepts and explanations could also be applied to FCM detection of other particles within the EV size range, such as bacteria, lipoprotein particles, milk fat globules, and viruses.
Characterization of Microvascular Invasion in Hepatocellular Carcinoma Using Computational Modeling of Interstitial Fluid Pressure and Velocity
Authors: Zheng Liyun , Yang Chun , Sheng Ruofan , Rao Shengxiang , Wu Lifang , Zeng Mengsu , Dai Yongming 
Published: February 2023

BackgroundMost solid tumors show increased interstitial fluid pressure (IFP), and this increased IFP is an obstacle to treatment. A noninvasive model for measuring IFP in hepatocellular carcinoma (HCC) is an unresolved issue.PurposeTo develop a noninvasive model to measure IFP and interstitial fluid velocity (IFV) in HCC and to characterize the microvascular invasion (MVI) status by using this model.Study TypeRetrospective.PopulationA total of 97 HCC patients (mean age 57.6 ± 10.9 years, 77.3% males), 53 of them with MVI and 44 of them without MVI.Field Strength/SequenceA 3‐T, three‐dimensional spoiled gradient‐recalled echo.AssessmentMVI was defined as microscopic vascular invasion of small vessels within the peritumoral liver tissue. The volumes of interest (VOIs) were manually delineated and enclosed the tumor lesion and healthy liver parenchyma, respectively. The extended Tofts model (ETM) was used to estimate permeability parameters from all the VOIs. Subsequently, the continuity partial differential equation (PDE) was implemented and IFP and IFV were acquired.Statistical TestsWilcoxon signed‐ranks tests, histogram analysis, Mann–Whitney U test, Fisher's exact test, least absolute shrinkage and selection operator (LASSO) logistic regression, receiver operating characteristic (ROC) curve analysis with the area under the curve (AUC), Youden index, DeLong test, and Benjamini–Hochberg correction. A P value <0.05 was considered statistically significant.ResultsThe HCC lesions exhibited elevated IFP and reduced IFV. There were no significant differences in any measured demographic and clinical features between the MVI‐positive and MVI‐negative groups, except for tumor size. Nine IFP histogram analysis‐derived parameters and seven IFV histogram analysis‐derived parameters could be used to characterize the MVI status. LASSO regression selected five features: IFP maximum, IFP 10th percentile, IFP 90th percentile, IFV SD, and IFV 10th percentile. The combination of these features showed the highest AUC (0.781) and specificity (77.3%).Data ConclusionA noninvasive IFP and IFV measurement model for HCC was developed. Specific IFP‐ and IFV‐derived parameters exhibited significant association with the MVI status.Evidence Level3.Technical EfficacyStage 2.