bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement properties of physical activity in adults with bronchiectasis: A systematic review protocol
Authors: Bhat Anup , Lee Annemarie L , Maiya G Arun , Vaishali K. 
Published: July 2023

Abstract: People with bronchiectasis reduce their physical activity (PA) due to muscle weakness, dyspnea, fatigue, reduced exercise capacity and frequent cough with expectoration. Patient-reported and objective physical assessment methods have been used to evaluate PA in people with bronchiectasis. In the literature, significant differences in the PA measured using patient-reported outcome measures when compared with the objective methods. Given the availability of many PA assessment tools, it is tedious for the clinician or researcher to choose an outcome measure for clinical practice or research. The evidence on validity and reliability in bronchiectasis are unclear. Objectives: To identify the PA assessment tools, describe and evaluate the literature on psychometric properties of instruments measuring and analyzing PA. Methods: The search will be conducted in PubMed/Medline, Cochrane Central Register of Controlled Studies, Scopus and EMBASE databases. The keywords, index terms and synonyms of the following words will be used: bronchiectasis, physical activity, and outcome measures. Published studies of adult with clinical and/ or radiologically diagnosed bronchiectasis, aged >18 years, any gender and studies that assessed PA and/or if there are reports on measurement properties of PA will be included in the review. Studies using qualitative research methods, narrative reviews, letters to editors and editorials will be excluded. The quality of the study will be assessed and data will be extracted. Any disagreement will be resolved in the presence of an author not involved in the screening or selecting studies. Discussion: By assessing the quality of studies on measurement properties, this review will help researchers choose the outcome measure to evaluate the effects of interventions on PA. This review will identify the suite of outcome measures of PA for people with bronchiectasis that can be used for research and clinical purpose.
Stereotactic radiotherapy for ventricular tachycardia: A study protocol
Authors: Kawamura Mariko , Shimojo Masafumi , Inden Yasuya , Kamomae Takeshi , Okudaira Kuniyasu , Komada Tomohiro , Aoki Sumire , Shindo Yurika , Yasui Ryotaro , Yanagi Yusuke , Okumura Masayuki , Yamada Takehiro , Kozai Yuka , Oie Yumi , Kato Yutaka , Ishihara Shunichi , Murohara Toyoaki , Naganawa Shinji 
Published: July 2023

Background: Currently, the standard curative treatment for ventricular tachycardia (VT) and ventricular fibrillation (VF) is radiofrequency catheter ablation. However, when the VT circuit is deep in the myocardium, the catheter may not be delivered, and a new, minimally invasive treatment using different energies is desired. Methods: This is a protocol paper for a feasibility study designed to provide stereotactic radiotherapy for refractory VT not cured by catheter ablation after at least one catheter ablation. The primary end point is to evaluate the short-term safety of this treatment and the secondary endpoint is to evaluate its efficacy as assessed by the reduction in VT episode. Cyberknife M6 radiosurgery system will be used for treatment, and the prescribed dose to the target will be 25Gy in one fraction. The study will be conducted on three patients. Conclusion: Since catheter ablation is the only treatment option for VT that is covered by insurance in Japan, there is currently no other treatment for VT/VF that cannot be cured by catheter ablation. We hope that this feasibility study will provide hope for patients who are currently under the stress of ICD activation. Trial registration: The study has been registered in the Japan Registry of Clinical Trials (jRCTs042230030).
Mushroom Sign: Complete Esophageal Obstruction After Esophageal Variceal Band Ligation With Successful Removal of Variceal Band
Authors: Gandhi Mustafa , Chela Harleen Kaur , Daglilar Ebubekir , Hammoud Ghassan 
Published: July 2023

ABSTRACT
Esophageal varices due to portal hypertension are treated with endoscopic variceal band ligation (EVBL), a minimally invasive procedure with potential complications, such as pain, bleeding, and stricture formation. Rarely, complete esophageal obstruction can occur secondary to edema of the mucosa. Most cases can be managed conservatively, but intervention is necessary for severe symptoms with a risk for aspiration and airway compromise. Since EVBL is such a common procedure, it is important for clinicians to be aware of this rare but severe complication. An 80-year-old woman presented with severe dysphagia and chest discomfort after a recent EVBL. Esophagogastroduodenoscopy revealed esophageal mucosal edema and complete obstruction of the esophageal lumen. The band was removed with a loop cutter with subsequent balloon dilation to relieve the obstruction.
Experience of successful laparoscopic sleeve resection of the stomach and treatment of morbid obesity in a patient with a classic form of congenital adrenal dysfunction
Authors: Zatsepina E. A. , Samoilov V. S. , Volynkina A. P. , Stepanenko A. V. , Novichikhina E. E. 
Published: July 2023

The article presents a clinical observation of a patient with congenital adrenal dysfunction (CHD), a salt-losing form of 21-hydroxylase enzyme deficiency (homozygous mutation I 172N), and also with morbid obesity, due to long-term use of high doses of glucocorticosteroids, who underwent bariatric surgery — laparoscopic sleeve resection of the stomach. A feature of the presented case is the elimination of one of the causes of decompensation of the disease, namely, overweight, as well as insulin resistance, which requires the intake of large doses of glucocorticoids, which in turn leads to a worsening of the course of obesity, thereby causing a vicious circle. 7 months after surgical treatment, the goal was achieved — a reduction in the dose of Prednisolone by 25%, with a decrease in body weight by 72.1% of overweight.The presented case clearly demonstrates the possibility of performing bariatric surgery for the treatment of morbid obesity in patients with CAH with the participation and control of a specialized multidisciplinary team. If there are indications for bariatric intervention, VDKN should not be an absolute contraindication to such operations, and the ratio of the safety profile and the efficacy profile testifies in favor of the need for their implementation.
The features of regulatory T-blood cells subpopulation and the level of CD25 expression in patients with Graves’ disease in dynamics after radioactive iodine therapy
Authors: Dudina M. A. , Savchenko A. A. , Dogadin S. A. , Borisov A. G. , Belenyuk V. D. 
Published: July 2023

BACKGROUND: The content of regulatory T cells (Treg) at different stages in formation of effector subpopulations and the level of CD25 expression on the membrane of their various fractions in Graves’ disease can determine the long-term autoimmune process persistence and be the target of immunotropic therapy of the disease.AIM: To study the features of regulatory T-blood cells subpopulation and the level of CD25 expression in patients with Graves’ disease in dynamics after radioactive iodine therapy (RIT) to identify the specific Treg subpopulations for potential immunotropic therapy targets of the disease.MATERIALS AND METHODS: A single-center, prospective, cohort, open, controlled study was conducted with the participation of women with laboratory-confirmed Graves’ disease. The features of regulatory T-blood cells subpopulation and the level of expression (MFI) CD25 surface receptor were studied by flow cytometry using direct immunofluorescence using monoclonal antibodies.RESULTS: The study included 36 women with recurrent Graves’ disease, middle age 46.34±14.32 years. In patients with Graves’ disease before and during the entire period after RIT a low percentage of naive (CD45R0-CD62L+) and terminally differentiated (CD45R0-CD62L-) Treg was established relative to the control, and on 3 and 6 months after RIT a significant decrease of cells with this phenotype was revealed relative to the values detected in patients before and 1 month after RIT (p<0.001). Against the background of compensated hypothyroidism the most significant changes of expression CD25 receptor in patients with Graves’ disease were found on 3 and 6 months after RIT: reduced levels of MFI CD25 on surface of naive and terminally differentiated Treg.CONCLUSION: A decrease in the level of naive Treg was found (apparently due to a violation of differentiation processes in thymus) and terminally differentiated Tregs (due to maturation and survival processes), which are supplemented by a reduced expression of the CD25 receptor on the surface of these cells and do not depend on hyperthyroidism compensation, the titer of TSH receptor antibodies, previous conservative therapy with thiamazole and RIT. The obtained new data reveal the role of naive and terminally differentiated Treg subpopulations in immunopathogenesis and help to outline further ways to develop approaches for immunotropic therapy.
Features of aging replicative and biochemical aspects among females with non-iatrogenic hypergonadotropic hypogonadism
Authors: Mikheev R. K. , Andreeva E. N. , Grigoryan O. R. , Sheremetyeva E. V. , Absatarova Yu. S. , Volevodz N. N. , Loginova E. V. 
Published: July 2023

BACKGROUND: Estrogenic deficiency is the basic condition of human ageing that leads to hypergonadotropic hypogonadism. The existence of correlation between hypergonadotropic hypogonadism, replicative (leukocyte telomere length) and biochemical data is widely supposed among females with physiological (menopausal) and pathological (primary ovarian insufficiency) estrogenic deficiency is not unreasonable.AIM: To evaluate features of replicative (telomere length) and biochemical (metabolic syndrome) ageing markers among females with physiological (menopausal) and pathological (primary ovarian insufficiency) estrogenic deficiency.MATERIALS AND METHODS: Research has been provided in collaboration between Endocrinology Research Centre of the Russian Ministry of Health and Lomonosov Moscow State University Medical Research and Educational Centre in the period since 10.01.2021 until 01.08.2022.110 females (20-75y.o.) have participated in the present research.Group 1: 26 females receiving menopausal hormonal therapy (MHT) ≥ 5 years with 0,5; 1; 2 mg estrogenic component.Group 2: 27 females in physiological menopause without MHTGroup 3: 33 females with primary ovarian insufficiency and receiving sex-steroid replacement therapy.Group 4: 24 healthy reproductive age females without sex-steroid replacement therapy.Patients have undergone laboratory genetic (leucocyte telomere length), biochemical analyses.DNA extraction — with Qiagen DNA blood mini kit (Germany). Biological material was cito conserved with Ficoll solution. Leukocyte telomere length — with real-time polymerase chain reaction PCR (Flow-fish).Soft program IBM SPSS Statistics (version 26,0 for Windows) has been used for statical analysis.RESULTS.1.Menopausal females receiving MHT were inclined to highest HDL-P levels (p<0,006).2.Females with primary ovarian insufficiency were inclined to relatively highest serum creatinine level (p<0,001).3.Reproductive age females had relatively highest telomere length (p<0,001).4.FSH level correlates negatively and moderately (ρ= - 0,434) leukocyte telomere length (р<0,001) among females.CONCLUSION: Females with premature ovarian insufficiency are most sensible to ageing due to features of replicative and biochemical markers.
O DILEMA DAS PLATAFORMAS E REDES DIGITAIS
Authors: Bortolazzo Sandro Faccin 
Published: July 2023

O Dilema das Redes”, documentário da Netflix, adverte como as empresas de tecnologia usam informações de usuários para potencializar negócios. Neste artigo, o objetivo é analisar como as plataformas digitais, inscritas na racionalidade neoliberal, têm produzido outras formas de docência e processos educativos. Trata-se de um estudo exploratório, seguindo dois movimentos. O primeiro adota a algoritmicidade (STALDER, 2018) e a Plataformização da Sociedade (VAN DIJCK, POELL E WAAL, 2018) como características estruturais na produção de sentidos. O segundo, seguindo Brown (2019), Dardot et.al (2021), Ball (2014), Foucault (1987; 2006), explora como as tecnologias digitais e o neoliberalismo se afinam a características incitadas nos sujeitos – flexibilidade, mobilidade, personalização–, permitindo pensar uma docência e processos educativos voláteis, e não mais atrelados a espaços físicos.
The inhibitory receptor Siglec‐G controls the severity of chronic lymphocytic leukemia
Authors: Röder Bettina , Fahnenstiel Hannah , Schäfer Simon , Budeus Bettina , Dampmann Maria , Eichhorn Melanie , Angermüller Sieglinde , Brost Claudia , Winkler Thomas H , Seifert Marc , Nitschke Lars 
Published: July 2023

AbstractChronic Lymphocytic Leukemia (CLL) is the most common leukemia in adults in the Western world. B cell receptor (BCR) signaling is known to be crucial for the pathogenesis and maintenance of CLL cells which develop from mature CD5+ B cells. BCR signaling is regulated by the inhibitory co‐receptor Siglec‐G and Siglec‐G‐deficient mice have an enlarged CD5+ B1a cell population. Here, we determine how Siglec‐G expression influences the severity of CLL. Our results show that Siglec‐G deficiency leads to earlier onset and more severe course of the CLL‐like disease in the murine Eμ‐TCL1 model. In contrast, mice overexpressing Siglec‐G on the B cell surface are almost completely protected from developing CLL‐like disease. Furthermore, we observe a downmodulation of the human ortholog Siglec‐10 from the surface of human CLL cells. These results demonstrate a critical role for Siglec‐G in disease progression in mice, and suggest that a similar mechanism for Siglec‐10 in human CLL may exist.
An extended transcription factor regulatory network controls hepatocyte identity
Authors: Dubois‐Chevalier Julie , Gheeraert Céline , Berthier Alexandre , Boulet Clémence , Dubois Vanessa , Guille Loïc , Fourcot Marie , Marot Guillemette , Gauthier Karine , Dubuquoy Laurent , Staels Bart , Lefebvre Philippe , Eeckhoute Jérôme 
Published: July 2023

AbstractCell identity is specified by a core transcriptional regulatory circuitry (CoRC), typically limited to a small set of interconnected cell‐specific transcription factors (TFs). By mining global hepatic TF regulons, we reveal a more complex organization of the transcriptional regulatory network controlling hepatocyte identity. We show that tight functional interconnections controlling hepatocyte identity extend to non‐cell‐specific TFs beyond the CoRC, which we call hepatocyte identity (Hep‐ID)CONNECT TFs. Besides controlling identity effector genes, Hep‐IDCONNECT TFs also engage in reciprocal transcriptional regulation with TFs of the CoRC. In homeostatic basal conditions, this translates into Hep‐IDCONNECT TFs being involved in fine tuning CoRC TF expression including their rhythmic expression patterns. Moreover, a role for Hep‐IDCONNECT TFs in the control of hepatocyte identity is revealed in dedifferentiated hepatocytes where Hep‐IDCONNECT TFs are able to reset CoRC TF expression. This is observed upon activation of NR1H3 or THRB in hepatocarcinoma or in hepatocytes subjected to inflammation‐induced loss of identity. Our study establishes that hepatocyte identity is controlled by an extended array of TFs beyond the CoRC.
Longitudinal trajectories of maternal TSH in healthy pregnant women in Catalonia
Authors: Soldevila Berta , Velasco Inés , Muñoz Carla , Díaz Yesika , Egea-Cortés Laia , Ferrer-Escopiñan Laura , Pérez-Montes de Oca Alejandra , Martínez-Mondejar Raquel , Casabona Jordi , Puig-Domingo Manel 
Published: July 2023

Objective
Longitudinal evaluation of thyroid function throughout pregnancy in the same subject could offer precise information about its dynamics as a physiological mechanism of adaption to the requirements. In this study, we evaluated longitudinal trajectories of maternal thyroid function during pregnancy by a latent class growth analysis and explored their association with maternal–fetal outcomes.

Methods
A prospective observational study was carried out, including 414 healthy pregnant women, from the first trimester to delivery. Thyroid function and autoimmunity were measured in the three trimesters. Clinical data during pregnancy were obtained. Longitudinal mixed model techniques were performed to explore trajectories of gestational thyroid function.

Results
Three different longitudinal trajectories were obtained from maternal thyrotropin (TSH) levels: low-increasing TSH (class 1) in 86% of cases, high-increasing TSH (class 2) in 9.7%, and decreasing TSH (class 3) in 4.3%. No statistical differences in free thyroxine levels were found among the three classes. Differences in maternal age (P = 0.027) and initial maternal weight (P = 0.043) were observed among the groups. In logistic regression analysis, maternal age correlated with longitudinal trajectories. The three longitudinal classes remain when women with thyroid autoimmunity (TAI) are excluded. Multinomial logistic regression showed maternal age correlated with longitudinal trajectories independently of TAI status.

Conclusions
Three differentiated TSH trajectories were found in healthy pregnant women living in Catalonia, as previously described. No association with obstetric outcomes was observed in these different chronological thyroid pathways, but maternal age might condition the longitudinal mechanism of thyroid function regulation throughout pregnancy.
МОДИФІКАЦІЯ ДОКУМЕНТУВАННЯ У КОНТЕКСТІ ЦИФРОВІЗАЦІЇ БУХГАЛТЕРСЬКОГО ОБЛІКУ
Authors: Shkromyda V.V. , Shkromyda N.Ya. , Gnatyuk T.M. 
Published: July 2023

В статті розглянуто зміни і доповнення, які виникають у процесі документування бізнес-процесів на підприємстві у контексті цифровізації бухгалтерського обліку і звітності. Завдяки швидкому розвитку технологій та впровадженню цифрових інструментів, бухгалтерія перетворюється з традиційного паперового процесу в автоматизовану електронну систему, яка приносить ряд переваг в управлінні підприємством. До ключових переваг цифровізації бухгалтерського обліку слід віднести точність облікових даних, зручний і швидкий доступ до них, а також високий рівень захисту і безпеки.
Позитивним аспектом на рівні держави є те, що у напрямку використання цифрових технологій в обліку і звітності прийнято низку законодавчих актів. Це створює сприятливу базу для розгортання та прискорення процесу цифрової трансформації у сфері бухгалтерського обліку і фінансової звітності, а також економічних взаємовідносин. В умовах цифровізації обліку і звітності спостерігається розширення реквізитів електронних облікових документів, яких раніше не існувало у паперовому форматі. Цей процес супроводжується перенесенням документообігу до віртуального простору. За допомогою розширених метаданих електронний формат надає можливість в реальному часі та оперативно змінювати структуру, зміст та порядок оформлення документів. Крім того, цифровізація бухгалтерського обліку покращує умови для організації документообігу у підприємстві. Вона дозволяє застосовувати об'єктноорієнтований підхід до побудови документообігу, що означає, електронні документи можуть переміщатись як вертикально (по ієрархічній ланці підтвердження), так і горизонтально (між різними відділами та структурними підрозділами). Це дає змогу оперативно адаптувати маршрути проходження документів в залежності від об'єктів, що документально оформлюються, та виробничих потреб, які змінюються на підприємстві.
Отримані наукові результати сприятимуть розвитку теоретико-методичної основи процесу оцінювання ефективності впровадження цифрового документування на підприємстві та пошуку шляхів покращення оперативності і надійності обліково-аналітичної інформації.
Assessing the significance of some biomarkers in perioperative period after thoracic aortic reconstruction
Authors: Akselrod B. A. , Dymova O. V. , Gubko A. V. , Krasnoshchekova A. P. , Guskov D. A. , Goncharova A. V. , Gladysheva V. G. , Gubko K. V. , Kulinchenko O. S. 
Published: July 2023

Aim. This study aims to assess the association between levels of biomarkers and postoperative complications in patients after thoracic and thoracoabdominal aortic reconstruction.Material and methods. This study included 132 patients. The most of them underwent ascending aortic and aortic arch reconstruction (65 and 57, respectively).The concentrations of proadrenomedullin, presepsin, procalcitonin, troponin I and N-terminal brain natriuretic peptide were measured before induction anesthesia, at the end of the surgical operation and in 6 hours after surgery.Results. 69 patients had postoperative complications. Among them, inflammatory (27,3%) and cardiovascular complications (12,1%) prevailed. At the end of the surgical operation, the levels of the biomarkers in patients without postoperative complications and with postoperative complications were for presepsin 326 [206; 451] и 620 [332; 829] p<0,00001, tropononin I 0,77 [0,46; 1,39] and 1,49 [0,59; 3,39], p=0,01, proadrenomedullin 0,894 [0,683; 1,221] and 1,201 [0,944; 1,762], p=0,0002, procalcitonin 0,206 [0,147; 0,452] and 0,563 [0,307; 2,107], p=0,0002, respectively. According to log-linear regression model, the level of prepepsin at the end of the surgical operation >459,5 (odds ratio (OR) 6,84, 95% confidence interval (CI): 3,14-14,87) or proadrenomedullin >0,788 (OR 5,47, 95% CI: 1,52-19,68) are associated with the increased risk of postoperative complications. The level of presepsin >519,5 pg/ml at the end of the surgical operation (OR 4,55, 95% CI: 1,97-10,47) is associated with the increased risk of inflammatory complications. Regarding the prognosis of the risk of prolonged cardiotonic drug infusions, threshold values for troponin were >1,04 at the end of the surgical operation (sensitivity 75%, specificity 71,3%, AUC 0,785), >1,57 in 6 hours after surgery (sensitivity 81,3%, specificity 71,6%, AUC 0,794).Conclusion. High levels of presepsin at the end of the surgical operation may be useful to predict the postoperative complications in patients who underwent the aortic surgery however, the low levels of presepsin do not exclude the development of postoperative complications. The increased level of troponin I at the end of the surgical operation and in 6 hours after surgery can be a predictor of the need for cardiotonic support in the postoperative period.