bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overburden stress evolution characteristics and prediction of disasters with across-gully mining
Authors: Wang Hongwei , Jiang Baolin , Jiao Jianqiang , Li Yanjun 
Published: February 2023

The coal water co-mining of shallow coal seams in the loess gully area of Northern Shaanxi is affected by the coupling effect of overburden rock structure and topography. The development characteristics of mining fracture are complex and can induce mining and environmental disasters. To predict the disaster formation, taking the 113101 working face of the Kunyuan Coal Mine as the engineering background, numerical simulation, physical similarity simulation experiment, and theoretical analysis methods were used to analyze the mining gully of a shallow coal seam in a loess gully area. Based on the dynamic evolution characteristics of stress at different locations, the formation positions, dynamic development, and evolution processes of various fractures were studied; disaster-causing mechanisms were revealed and comprehensive methods were proposed. The results showed that in across-gully mining, the maximum horizontal compressive stress at the bottom of Gully No. 2 was approximately 20.00 MPa, the maximum horizontal tensile stress of the reverse slope section was approximately 1.50 MPa, the width of the F5 fracture of Gully No. 2 was 46.00 cm, and the elevation difference was up to 52.00 cm. The working face across-gully mining formed tensile fractures in most areas, collapsed fractures at the gully bottom, and extruded fractures in the reverse slope section. The fracture at the gully bottom could easily induce water–sand inrush and roof caving and supports crushing. The slope fracture could also induce a gully-induced landslide. According to the mechanisms and distribution areas of fracture disasters, the disaster areas were divided into water–sand inrush areas at the gully bottom, roof caving and supports crushing areas at the gully bottom and at the base of the slope section, and landslide areas at the upper part of the slope section and reverse slope section. Appropriate prevention and control measures were proposed, such as the upstream interception of surface water, slope reinforcement in the middle and upper part of the downhill section, artificial precracking of the roof in the middle and upper part of the downhill section, and grouting reinforcement at the gully bottom and slope toe of the downhill section. These measures were proven to effectively guarantee the safe and efficient mining efficiency of the working face.
Nerve conduction velocity is independently associated with bone mineral density in type 2 diabetes mellitus
Authors: Chen Xiao-jing , Wang Xiao-feng , Pan Zheng-can , Zhang Deng , Zhu Ke-cheng , Jiang Tao , Kong Xiao-ke , Xie Rui , Sun Li-hao , Tao Bei , Liu Jian-min , Zhao Hong-yan 
Published: February 2023

AimThis study investigated the association between nerve conduction velocity (NCV) and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).MethodsThis study retrospectively collected medical data of T2DM patients who underwent dual-energy X-ray absorptiometry and nerve conduction study at the Shanghai Ruijin Hospital, Shanghai, China. The primary outcome was the total hip BMD T-score. The main independent variables were motor nerve conduction velocities (MCVs), sensory nerve conduction velocities (SCVs), and composite Z-scores of MCV and SCV. T2DM patients were divided into total hip BMD T-scores &lt; -1 and total hip BMD T-scores ≥ -1 groups. The association between the primary outcome and main independent variables was evaluated by Pearson bivariate correlation and multivariate linear regression.Results195 female and 415 male patients with T2DM were identified. In male patients with T2DM, bilateral ulnar, median, and tibial MCVs and bilateral sural SCVs were lower in the total hip BMD T-score &lt; -1 group than T-score ≥ -1 group (P &lt; 0.05). Bilateral ulnar, median, and tibial MCVs, and bilateral sural SCVs showed positive correlations with total hip BMD T-score in male patients with T2DM (P &lt; 0.05). Bilateral ulnar and tibial MCVs, bilateral sural SCVs, and composite MCV SCV and MSCV Z-scores were independently and positively associated with total hip BMD T-score in male patients with T2DM, respectively (P &lt; 0.05). NCV did not show significant correlation with the total hip BMD T-score in female patients with T2DM.ConclusionNCV showed positive association with total hip BMD in male patients with T2DM. A decline in NCV indicates an elevated risk of low BMD (osteopenia/osteoporosis) in male patients with T2DM.
Sex- and age-specific association between outdoor light at night and obesity in Chinese adults: A national cross-sectional study of 98,658 participants from 162 study sites
Authors: Zhang Xiaoyun , Zheng Ruizhi , Xin Zhuojun , Zhao Zhiyun , Li Mian , Wang Tiange , Xu Min , Lu Jieli , Wang Shuangyuan , Lin Hong , Wang Weiqing , Ning Guang , Bi Yufang , Chen Yuhong , Xu Yu 
Published: February 2023

BackgroundExposure to light at night (LAN) is a potent disruptor of the circadian system. Whether LAN exposure exerts a sex- or age-specific influence on obesity needs investigation.ObjectivesTo estimate the sex- and age-specific associations of exposure to outdoor LAN and obesity based on a national and cross-sectional survey.MethodsThe study included a nationally representative sample of 98,658 adults aged ≥ 18 years who had lived in their current residence for ≥ 6 months from 162 study sites across mainland China in 2010. Outdoor LAN exposure was estimated from satellite imaging data. General obesity was defined as body-mass index (BMI) ≥ 28 kg/m2 and central obesity was defined as waist circumference ≥ 90 cm in men and ≥ 85 cm in women. Linear and logistic regression models were used to examine the associations between LAN exposure and prevalent obesity in sex and age categories.ResultsA monotonically increasing association of outdoor LAN with BMI, waist circumference was observed in all sex and age categories, except for adults aged 18-39 years. Significant associations of LAN exposure with prevalent obesity were observed in each sex and age category, especially in men and older people. Per 1-quintile increase in LAN was associated with 14% increased odds of general obesity in men (odds ratio, OR=1.14, 95% confidence interval, CI=1.07-1.23) and 24% in adults aged ≥ 60 years (OR=1.24, 95% CI=1.14-1.35). Per 1-quintile increase in LAN was associated with 19% increased odds of central obesity in men (OR=1.19, 95% CI=1.11-1.26) and 26% in adults aged ≥ 60 years (OR=1.26, 95% CI=1.17-1.35).ConclusionsIncreased chronic outdoor LAN exposure was associated with increased prevalence of obesity in sex- and age- specific Chinese populations. Public health policies on reducing light pollution at night might be considered in obesity prevention.
Simple model of morphometric constraint on carbon burial in boreal lakes
Authors: Cael B. B. , Seekell David A. 
Published: February 2023

A geometric theory was developed to explain the empirical relationship between carbon burial and lake shape in boreal lakes. The key feature of this model is an attenuation length scale, analogous to models of marine organic carbon fluxes. This length scale is the ratio of how fast carbon is displaced vertically versus how fast it is respired and engenders a simple model with a single easily constrained free parameter. Lake depths are modeled based on fractal area–volume relationships that reflect the approximate scale invariance of Earth’s topography on idealized lake geometries. Carbon burial is estimated by applying the attenuation length scale to these depths. Using this model, we demonstrate the relationship between the dynamic ratio—a metric of lake morphometry calculated by dividing the square root of surface area by the mean depth—and carbon burial. We use scaling relationships to predict how dynamic ratio, and by extension carbon burial, varies across the lake size spectrum. Our model also provides a basis for generalizing empirical studies to the biome scale. By applying our model to a boreal lake census, we estimate boreal lake carbon burial to be 1.8 ± 0.5 g C/m2/yr or 1.1 ± 0.3 Tg C/yr among all boreal lakes.
Understanding the adsorption of iron oxide nanomaterials in magnetite and bimetallic form for the removal of arsenic from water
Authors: Boruah Himangshu , Tyagi Neha , Gupta Sanjay Kumar , Chabukdhara Mayuri , Malik Tabarak 
Published: February 2023

Arsenic decontamination is a major worldwide concern as prolonged exposure to arsenic (&gt;10 µg L-1) through drinking water causes serious health hazards in human beings. The selection of significant, cost-effective, and affordable processes for arsenic removal is the need of the hour. For the last decades, iron-oxide nanomaterials (either in the magnetite or bimetallic form) based adsorptive process gained attention owing to their high arsenic removal efficiency and high regenerative capacity as well as low yield of harmful by-products. In the current state-of-the-art, a comprehensive literature review was conducted focused on the applicability of iron-based nanomaterials for arsenic removal by considering three main factors: (a) compilation of arsenic removal efficiency, (b) identifying factors that are majorly affecting the process of arsenic adsorption and needs further investigation, and (c) regeneration capacity of adsorbents without affecting the removal process. The results revealed that magnetite and bimetallic nanomaterials are more effective for removing Arsenic (III) and Arsenic (V). Further, magnetite-based nanomaterials could be used up to five to six reuse cycles, whereas this value varied from three to six reuse cycles for bimetallic ones. However, most of the literature was based on laboratory findings using decided protocols and sophisticated instruments. It cannot be replicated under natural aquatic settings in the occurrence of organic contents, fluctuating pH and temperature, and interfering compounds. The primary rationale behind this study is to provide a comparative picture of arsenic removal through different iron-oxide nanomaterials (last twelve yearsof published literature) and insights into future research directions.
Knowledge and attitude of women towards maternity waiting homes and associated factors among women who gave birth in the last twelve months in Dega Damot district, northwest Ethiopia
Authors: Anteneh Tazeb Alemu , Solomon Abayneh Aklilu , Tamiru Animut Tagele , Tibebu Nebiyu Solomon , Abegaz Marta Yimam , Temesgan Wubedle Zelalem , Kebede Azmeraw Ambachew , Aklil Mastewal Belayneh , Mesele Tiruye Tilahun , Tiruye Tiringo Molla 
Published: February 2023

BackgroundMaternal waiting homes have been identified as one strategy to reduce maternal and perinatal mortality by bringing women living in hard-to-reach areas closer to a health facility that provides emergency obstetric care. Even if utilization of maternal waiting homes is repeatedly assessed, there is a scarcity of evidence in Ethiopia regarding women's knowledge and attitude towards maternal waiting homes.ObjectiveThis study aimed to assess women's knowledge and attitude towards maternity waiting homes and associated factors among women who gave birth in the last twelve months in northwest Ethiopia.MethodsA community-based cross-sectional study was conducted from January 1st to February 30th, 2021. A total of 872 participants were selected by using a stratified cluster sampling technique. Data were collected by face-to-face interviews using a structured, pretested, and interviewer-administered questionnaire. Data were entered into EPI data version 4.6 and analysis was done through SPSS version 25. The multivariable logistic regression model was fitted and the level of significance was declared at a p-value of ≤0.05.ResultWomen's adequate knowledge and positive attitude towards maternal waiting homes were 67.3% (95% CI: 64–70) and 73% (95% CI: 70–76), respectively. Had antenatal care visit, the shortest distance to reach the nearby health facility, had history of maternal waiting homes utilization, always involved in health care decision, and sometimes involved in health care decisions were significantly associated with women's knowledge regarding maternal waiting homes. Moreover, secondary and above educational level of women, short distance to reach the nearby health facility and had antenatal care visit were significantly associated with women's attitude towards maternity waiting homes.ConclusionAbout two-third of women had adequate knowledge and nearly three-fourth of women had a positive attitude towards maternity waiting homes. It is better to improve the accessibility and utilization of maternal health services Furthermore, it is better to promote women's decision making power and create motivation to have better academic achievement of women.
scRNA-seq reveals aging-related immune cell types and regulators in vaginal wall from elderly women with pelvic organ prolapse
Authors: Miao Yali , Wen Jirui , Wang Ling , Wen Qiao , Cheng Juan , Zhao Zhiwei , Wu Jiang 
Published: February 2023

IntroductionIn the pathology of pelvic organ prolapse (POP), little is known about the contributing role of pelvic microenvironment. Also, the age-related differences in pelvic microenvironment of POP patients is always ignored. In the present study, we investigated the age-related differences in pelvic microenvironment between Young POP patients and Old POP patients, and the novel cell types and critical regulators which contributes to the age-related differences.MethodsSingle-cell transcriptomic analyses were used to detect the changes in cell composition and gene expression from the pelvic microenvironment of control group (&lt;60 years), Young POP group (&lt;60 years) and Old POP group (&gt;60 years). Then, immunohistochemistry and immunofluorescence were used to verify the novel cell types and critical regulators in the pelvic microenvironment. Furthermore, histopathological alteration and mechanical property alteration in POP with different ages were revealed by vaginal tissue histology and biomechanical testing.ResultsThe up-regulated biological process in Old women with POP is mainly related to chronic inflammation, while the up-regulated biological process in Young women with POP is mainly related to extracellular matrix metabolism. Meantime, CSF3+ endothelial cells and FOLR2+ macrophages were found to play a central role in inducing pelvic chronic inflammation. Furthermore, the collagen fiber and mechanical property of POP patients decreased with aging.ConclusionsTaken together, this work provides a valuable resource for deciphering the aging-related immune cell types and the critical regulators in pelvic microenvironment. With better understanding of normal and abnormal events in this pelvic microenvironment, we provided rationales of personalized medicine for POP patients with different ages.
Identification of copper death-associated molecular clusters and immunological profiles in rheumatoid arthritis
Authors: Zhou Yu , Li Xin , Ng Liqi , Zhao Qing , Guo Wentao , Hu Jinhua , Zhong Jinghong , Su Wenlong , Liu Chaozong , Su Songchuan 
Published: February 2023

ObjectiveAn analysis of the relationship between rheumatoid arthritis (RA) and copper death-related genes (CRG) was explored based on the GEO dataset.MethodsBased on the differential gene expression profiles in the GSE93272 dataset, their relationship to CRG and immune signature were analysed. Using 232 RA samples, molecular clusters with CRG were delineated and analysed for expression and immune infiltration. Genes specific to the CRGcluster were identified by the WGCNA algorithm. Four machine learning models were then built and validated after selecting the optimal model to obtain the significant predicted genes, and validated by constructing RA rat models.ResultsThe location of the 13 CRGs on the chromosome was determined and, except for GCSH. LIPT1, FDX1, DLD, DBT, LIAS and ATP7A were expressed at significantly higher levels in RA samples than in non-RA, and DLST was significantly lower. RA samples were significantly expressed in immune cells such as B cells memory and differentially expressed genes such as LIPT1 were also strongly associated with the presence of immune infiltration. Two copper death-related molecular clusters were identified in RA samples. A higher level of immune infiltration and expression of CRGcluster C2 was found in the RA population. There were 314 crossover genes between the 2 molecular clusters, which were further divided into two molecular clusters. A significant difference in immune infiltration and expression levels was found between the two. Based on the five genes obtained from the RF model (AUC = 0.843), the Nomogram model, calibration curve and DCA also demonstrated their accuracy in predicting RA subtypes. The expression levels of the five genes were significantly higher in RA samples than in non-RA, and the ROC curves demonstrated their better predictive effect. Identification of predictive genes by RA animal model experiments was also confirmed.ConclusionThis study provides some insight into the correlation between rheumatoid arthritis and copper mortality, as well as a predictive model that is expected to support the development of targeted treatment options in the future.
Identification of a novel senescence-associated signature to predict biochemical recurrence and immune microenvironment for prostate cancer
Authors: Han Chenglin , Deng Yuxuan , Yang Bin , Hu Peng , Hu Bintao , Wang Tao , Liu Jihong , Xia Qidong , Liu Xiaming 
Published: February 2023

BackgroundProstate cancer (PCa) is an age-associated malignancy with high morbidity and mortality rate, posing a severe threat to public health. Cellular senescence, a specialized cell cycle arrest form, results in the secretion of various inflammatory mediators. In recent studies, senescence has shown an essential role in tumorigenesis and tumor development, yet the extensive effects of senescence in PCa have not been systematically investigated. Here, we aimed to develop a feasible senescence-associated prognosis model for early identification and appropriate management in patients with PCa.MethodThe RNA sequence results and clinical information available from The Cancer Genome Atlas (TCGA) and a list of experimentally validated senescence-related genes (SRGs) from the CellAge database were first obtained. Then, a senescence-risk signature related with prognosis was constructed using univariate Cox and LASSO regression analysis. We calculated the risk score of each patient and divided them into high-risk and low-risk groups in terms of the median value. Furthermore, two datasets (GSE70770 and GSE46602) were used to assess the effects of the risk model. A nomogram was built by integrating the risk score and clinical characteristics, which was further verified using ROC curves and calibrations. Finally, we compared the differences in the tumor microenvironment (TME) landscape, drug susceptibility, and the functional enrichment among the different risk groups.ResultsWe established a unique prognostic signature in PCa patients based on eight SRGs, including CENPA, ADCK5, FOXM1, TFAP4, MAPK, LGALS3, BAG3, and NOX4, and validated well prognosis-predictive power in independent datasets. The risk model was associated with age and TNM staging, and the calibration chart presented a high consistency in nomogram prediction. Additionally, the prognostic signature could serve as an independent prediction factor due to its high accuracy. Notably, we found that the risk score was positively associated with tumor mutation burden (TMB) and immune checkpoint, whereas negatively correlated with tumor immune dysfunction and exclusion (TIDE), suggesting that these patients with risk scores were more sensitive to immunotherapy. Drug susceptibility analysis revealed differences in the responses to general drugs (docetaxel, cyclophosphamide, 5-Fluorouracil, cisplatin, paclitaxel, and vincristine) were yielded between the two risk groups.ConclusionIdentifying the SRG-score signature may become a promising method for predicting the prognosis of patients with PCa and tailoring appropriate treatment strategies.
Swiss Sepsis National Action Plan: A coordinated national action plan to stop sepsis-related preventable deaths and to improve the support of people affected by sepsis in Switzerland
Authors: Schlapbach Luregn J. , Zimmermann Elisa A. , Meylan Sylvain , Stocker Martin , Suter Peter M. , Jakob Stephan M. , National Action Plan Working Group on behalf of the Swiss Sepsis 
Published: February 2023

BackgroundSepsis is a devastating disease which causes yearly over 10 million deaths worldwide. In 2017, the World Health Organization (WHO) issued a resolution prompting member states to improve the prevention, recognition, and management of sepsis. The 2021 European Sepsis Report revealed that—contrary to other European countries—Switzerland had not yet actioned the sepsis resolution.MethodsA panel of experts convened at a policy workshop to address how to improve awareness, prevention, and treatment of sepsis in Switzerland. Goal of the workshop was to formulate a set of consensus recommendations toward creating a Swiss Sepsis National Action Plan (SSNAP). In a first part, stakeholders presented existing international sepsis quality improvement programs and national health programs relevant for sepsis. Thereafter, the participants were allocated into three working groups to identify opportunities, barriers, and solutions on (i) prevention and awareness, (ii) early detection and treatment, and (iii) support for sepsis survivors. Finally, the entire panel summarized the findings from the working groups and identified priorities and strategies for the SSNAP. All discussions during the workshop were transcribed into the present document. All workshop participants and key experts reviewed the document.ResultsThe panel formulated 14 recommendations to address sepsis in Switzerland. These focused on four domains, including (i) raising awareness in the community, (ii) improving healthcare workforce training on sepsis recognition and sepsis management; (iii) establishing standards for rapid detection, treatment and follow-up in sepsis patients across all age groups; and (iv) promoting sepsis research with particular focus on diagnostic and interventional trials.ConclusionThere is urgency to tackle sepsis. Switzerland has a unique opportunity to leverage from lessons learnt during the COVID-19 pandemic to address sepsis as the major infection-related threat to society. This report details consensus recommendations, the rationale thereof, and key discussion points made by the stakeholders on the workshop day. The report presents a coordinated national action plan to prevent, measure, and sustainably reduce the personal, financial and societal burden, death and disability arising from sepsis in Switzerland.