bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-k Dual Crosslinkable Polymer Nanocomposite Dielectrics Based on P(MMA-co-HEMA)/BaTiO 3 for Film Capacitors
Authors: Hou Xiaoya , Zhang Yulei , Yin Zhangmin , Zhang Jie 
Published: August 2023

Abstract
In order to obtain high-quality photocrosslinkable polymer matrix, cinnamoyl chloride functionalized poly(methyl methacrylate-co-2-hydroxyethyl methacrylate) [f-P(MMA-co-HEMA)] was synthesized. The functionalization and photocrosslinking of the polymer were confirmed through FTIR, 1H NMR, and UV characterization. In order to obtain high-quality, flat and pinhole-free polymer films, the effects of different photocrosslinked processes on the polymer film quality were investigated. When the crosslinking time was 10 min and the crosslinking degree was 55%, the dielectric constant of the capacitor reached to 4.65, the dielectric loss was as low as 0.04, the dielectric strength was as high as 343 V/µm, and the maximum energy density was 2.4 J/cm3. In order to obtain composite materials with high dielectric constant, photocrosslinkable functionalized copolymer f-P(MMA-co-HEMA) was used as the polymer matrix, and surface modified BT with phosphoric acid was introduced through ball milling dispersion to prepare photocrosslinkable f-P(MMA-co-HEMA)/m-BT composite film. By surface and cross-sectional SEM characterization, BT was uniformly dispersed in the polymer matrix. FTIR confirmed that the C = C group on the surface modified BT disappeared after photocrosslinking, which formed chemical binding between the two phases in the nanocomposite material, and the composite material formed a double crosslinking network structure. When the BT content was 30 wt%, the dielectric constant reached up to 51. With the bending angle of the capacitor changed by 120֯, the capacitance value changed by 27%, indicative of good sensitivity.
Magnetic resonance imaging-guided intracranial resection of glioblastoma tumors in patient-derived orthotopic xenografts leads to clinically relevant tumor recurrence
Authors: Oudin Anais , Moreno-Sanchez Pilar M. , Baus Virginie , Niclou Simone P. , Golebiewska Anna 
Published: August 2023

Abstract
Background
Preclinical in vivo cancer models are essential tools for investigating tumor progression and response to treatment prior to clinical trials. Although treatment modalities are regularly assessed in mice upon tumor growth in vivo, surgical resection remains challenging, particularly in the orthotopic site. Here, we report a successful surgical resection of glioblastoma (GBM) in patient-derived orthotopic xenografts (PDOXs).
Methods
We derived a cohort of 46 GBM PDOX models accurately recapitulating human disease in mice. To assess feasibility of surgical resection in PDOXs, we selected two models representing histopathological features of GBM tumors, including diffuse growth into the mouse brain. Tumor growth was detected with magnetic resonance imaging (MRI). Surgical resection in the mouse brains was performed based on MRI-guided coordinates. Survival study followed by immunohistochemistry-based evaluation of recurrent tumors allowed for assessment of clinically relevant parameters.
Results
We show that a surgical resection protocol in mice carrying diffuse GBM tumors in the brain leads to clinically relevant outcomes. We demonstrate the utility of MRI for the noninvasive assessment of in vivo tumor growth, preoperative programming of resection coordinates and follow-up of tumor recurrence. Similar to neurosurgery in patients, we achieved a near total to complete extent of tumor resection, and mice with resected tumors presented significantly increased survival. The remaining unresected GBM cells that invaded the normal mouse brain prior to surgery regrew tumors with similar histopathological features and tumor microenvironments to the primary tumors.
Conclusions
Our data positions GBM PDOXs developed in mouse brains as a valuable preclinical model for conducting therapeutic studies that involve surgical tumor resection. Additionally, these models hold promise for the development of enhanced image-guided surgery protocols.
Role and Clinical Significance of Thromboelastography-Guided Individualized Antiplatelet Therapy in Non-cardiogenic Ischemic Stroke: A Retrospective Cohort Study
Authors: Zhang Yifan , Wang Moli 
Published: August 2023

Abstract
This study examined the impact of individualized antiplatelet (IA) therapy guided by Thromboelastography (TEG) in non-cardiogenic ischemic stroke patients. The patients were divided into an IA group and a control group receiving conventional treatment. A one-year follow-up tracked mortality, bleeding events, and ischemic events. 715 patients were initially enrolled, with 684 meeting the inclusion criteria (487 in IA group, 197 in control group). IA therapy significantly reduced the composite rate of death, bleeding, or ischemic events compared to conventional therapy (7.39% vs. 15.74%, P = 0.001). The IA group showed a lower incidence of combined bleeding or ischemic events (6.98% vs. 15.32%, P = 0.001). Furthermore, the IA group had lower rates of ischemic stroke (2.46% vs. 5.58%, P = 0.04) and myocardial infarction (3.08% vs. 6.6%, P = 0.035) compared to the control group. Cox regression analysis revealed that age (hazard ratio, 1.043; 95% CI, 1.01-1.078, P = 0.011) and coronary artery disease (hazard ratio, 1.902; 95% CI, 1.147-3.153, P = 0.013) were associated with increased risk of adverse events compared to the control group. A therapy guided by platelet function testing can effectively reduce adverse events, particularly the risk of ischemic events, in the clinical prognosis of ischemic stroke. However, Caution is needed in IA therapy for elderly and coronary heart disease patients due to potential risks. Further large-scale experiments are required to validate and optimize personalized antiplatelet therapy in this population.
Trial Registration clinicaltrials.gov Identifier: NCT 03471169
Association between Economic Status and Post-stroke Depression in Middle and Older Age: Results from China Health and Retirement Longitudinal Study (CHARLS)
Authors: Cai Qianru , Qian Mengyi , Chen Meiling 
Published: August 2023

Abstract
Introduction: Post-stroke depression (PSD) is a common neuropsychiatric complication that affects approximately one-third of stroke patients. The prognosis and treatment of this disease are poor.There have been many studies exploring PSD risk factors, but previous studies have rarely focused on economic conditions and have not explored the role of urban-rural differences in PSD. Given the substantial population of stroke patients in China, it is crucial to examine the potential risk factors, including economic factors, contributing to PSD. By conducting studies on this population and investigating the influence of economic conditions, we can gain valuable theoretical insights to guide PSD prevention and management.
Methods: We utilized data from the 2018 CHARLS and selected appropriate samples for analysis. Depressive symptoms were assessed using the CES-D 10 scale, a validated tool for measuring depressive symptoms in the general population. Multiple logistic regression analysis was employed to assess the association between economic status and post-stroke depression and evaluate any urban-rural differences.
Results: Of the 1009 respondents in the study, 446 (44.2%) had depression. After adjusting for all covariates, we found that in the urban sample, participants with more health insurance cases had a lower risk of PSD (OR=0.19, 95% CI: 0.04-0.85, P=0.03). Conversely, in the rural sample, a significant correlation was reported between individual annual income and PSD occurrence (OR=0.19, 95% CI: 0.05-0.73, P=0.02).
Conclusions: Self-reported health status, number of other disabilities, night sleep duration, ADL, and life satisfaction also influenced PSD. The research results confirm that the increase of incidence rate of post-stroke depression (PSD) is related to many factors. Higher prevalence rates were observed in individuals with poorer economic conditions. This connection is particularly evident when comparing urban and rural areas. By addressing these factors and improving the economic situation, we can reduce the prevalence of PSD and strengthen comprehensive management of this situation.
The antihyperglycemic potential of pyraozolobenzothiazine 1,1-dioxide novel derivative in mice using integrated molecular pharmacological approach
Authors: Taj Saman , Ashfaq Usman Ali , Ahmad Matloob , Noor Hasnat , Ikram Ayesha , Ahmed Rashid , Tariq Muhammad , Masoud Muhammad Shareef , Hasan Anwarul 
Published: August 2023

Abstract
Diabetes Mellitus (DM) is a extensively studied metabolic disease characterized by elevated blood sugar levels caused by inadequate insulin production, which subsequently leads to hyperglycemia. This study was intended to investigate the in silico, in vitro, and in vivo antidiabetic potential of pyrazolobenzothiazine derivatives. Molecular docking of pyrazolobenzothiazine derivatives was performed against α-glucosidase and α-amylase and compounds were selected based on docking score, bonding interactions and low root mean square deviation (RMSD). In vitro enzyme inhibition assay against α-glucosidase and α-amylase was performed using p-nitrophenyl- α -D-glucopyranoside (PNPG) and starch substrate. Synthetic compound S1 exhibits little conformational changes during MD simulation run at 100ns. S1 also revealed effective IC50 values for α-glucosidase (3.91 µM) and α-amylase (8.89 µM) and an enzyme kinetic study showed low ki (-0.186, -1.267) and ki’ (-0.691, -1.78) values with the competitive type of inhibition for both enzymes α-glucosidase and α-amylase, respectively. Moreover, studies were conducted to check the effect of the synthetic compound in a mouse model. A low necrosis rate was observed in the liver, kidney, and pancreas through histology analysis performed on mice. Compound S1 also exhibited good biochemical profile with lower sugar level (110–115 mg/dL), increased insulin level (25–30 µM/L), and low level of cholesterol (85mg/dL) and creatinine (0.6 mg/dL) in blood. The treated mice group also exhibited a low % of glycated hemoglobin (3%). This study concludes that S1 is a new antidiabetic agent that helps lower blood glucose levels and minimizes the complications associated with type II diabetes.
Understanding the Role of Digital Immersive Technology in Educating the Students of English Language: Does it Promote Critical Thinking and Self-directed Learning for Achieving Sustainability in Education with the Help of Teamwork?
Authors: Tang Fenghua 
Published: August 2023

Abstract
Purpose:Universities are constantly searching for best practices to promote sustainability when it comes to educating students of the English language. Although this area of study has recently gained the attention of scholars around the worldthere is still a need to explore it from various perspectives.
Objective:The study aims to find out how well digital immersion technology encourages teamwork, self-directed learning, and critical thinking in English language learners. The purpose of the study is to examine how students' language skills, motivation, and involvement in the learning process are affected by digital immersive technology.
Methodology:The objective was achieved by using a survey questionnaire to collect data from 304 registered students in various universities inBeijing. Data analysis was conducted by applying Mplus 7.0 software.
Findings:The findings revealed that the use of digital immersive technology was pivotal for achieving sustainable education both directly and indirectly to an extent. In addition, team working moderated all the respective paths except the path involving the use of digital immersive technology and critical thinking.
Implications:These results generated implications for teachers and policymakersto promote and facilitate the use of digital technology for teaching the English language to students, encouraging them to develop critical skills and self-directed learning strategies. The study also offered guidance and deeper understanding for researchers to address the concerns linked to the use of digital technology and sustainable education particularly in their future endeavors.
Assessment of Frailty in patients with Advanced Chronic Kidney Disease and the role of Circulating Microvesicles
Authors: Gimena Rocio , Valera Gemma , Rodriguez Maria del Mar , Perez Maria , Arevalo Juan , Waikar Sushrut , Ramirez Rafael , Rodriguez Diego , Carracedo Julia , Martinez Patricia 
Published: August 2023

Abstract
Frailty is a highly prevalent syndrome inpatients with advanced age and chronic diseases, and it is associated with atherothrombotic pathologies, suggesting a procoagulant state in these patients. Circulating microvesicles (cMVs), are small phospholipid-rich vesicles, which have been shown to participate in atherothrombotic onset and progression. We aim to analyze frailty in patients with advanced chronic kidney disease (CKD), and to determine the role of microvesicles in this population.
We conducted a prospective cohort study with 85 patients with advanced CKD. Fried's five criteria were used to define frailty. We obtained blood for cMVs analysis by flow cytometry. There was a follow-up time of 27 months during which dialysis initiation and mortality was assessed.
The prevalence of frailty in patients with advanced CKD was 27%. We found that risk factors for frailty were age, type 2 diabetes mellitus and anemia. Total cMVs, platelet derived cMVs and endothelial derived cMVs were significantly higher in frail patients. CD142 (platelet tissue factor), a procoagulant marker, was also significantly higher in frail patients. Although we still do not know in depth the mechanisms involved in frailty, to our knowledge this is the first study that links cMVs and frailty in patients with advanced CKD, suggesting this could be a good biomarker or therapeutic target in advanced CKD.
Comparative therapeutic efficacy of intramammary Ceftiofur hydrochloride and Cefalonium during dry period in buffaloes
Authors: Kaushik Apurv , Walwadkar Kanchan , Yadav Sarita , Boora Ashok , Vandre Rajesh Kumar , Gupta Nitin Mohan , Sharma Sapna 
Published: August 2023

Abstract
Subclinical Mastitis (SCM) is mainly the major form of mastitis in modern livestock dairy animals. Antibiotic dry animal therapy proves to decrease risk of early lactation SCM. This study was designed to differentiate and compare efficacy of intramammary preparations i.e., Ceftiofur hydrochloride and Cefalonium during the dry period in buffaloes. The proposed work was carried out at ICAR- CIRB, Hisar, Haryana. Seventy-five buffaloes positive for SCM were randomized in three groups with 25 buffaloes in each group- two treatment groups (T2 and T3) and one untreated control group (T1). T2 group buffaloes were treated with drug Ceftiofur hydrochloride (500 mg) and T3 group with Cefalonium formulation (250 mg). Therapeutic efficacies of both the drugs were evaluated based on bacterial cure rates and Odd Ratios (OR). T2 treatment group showed better therapeutic response as compared to T3 groups the bacterial cure rate was 88% and 48% respectively, and the Odd Ratio (OR) of treatment group T2 was 0.0057 which was lower as compared to group T3 which was 0.0451.
Research and Application of Plastic Extruder Temperature System Based on Variable Universe Fuzzy PID Control
Authors: Meng Jin-Tao , Gao Hai-Tao , Ruan Mi-Xue , Sun Wen , Guo Hai 
Published: August 2023

Abstract
Plastic profiles, as the basic material for social and economic development, are mainly processed and moulded by plastic extruders. In the production process of plastic profiles, the temperature precision control of plastic extruder directly affects the plasticising and mixing effect of raw mate-rials. Therefore, the development of high-precision, fast response and stable plastic extruder tem-perature control system plays a key role in the development of plastic profile industry. In order to solve the shortcomings of the plastic extruder such as low temperature precision, slow response speed and poor anti-interference ability, the author has established a plastic extruder temperature control system model based on the study of PID control strategies and fuzzy PID control strategies, combined with the structural and functional characteristics of plastic extruder. Adopting a variable universe fuzzy PID control strategy to improve the performance of the plastic extruder temperature control system. The core idea of this strategy is to introduce proportional factors to change the range of the fuzzy domain. Under the condition that the fuzzy rules remain unchanged, the fuzzy domain compresses as the error decreases and expands as the error increases. Changing the domain is equivalent to adding fuzzy control rules within the same domain, thereby completing the dynamic adjustment of PID controller parameters. Through MATLAB simulation analysis and comparison, it was found that this control strategy has the advantages of short rise time, no overshoot, and strong anti-interference compared to PID control and fuzzy PID control strategies. Finally, through ex-perimental verification, it was found that this control strategy significantly changes the temperature control effect of nonlinear time-varying extruders, and has good adaptability and stability.
Incidence and factors associated with failed spinal anaesthesia among patients undergoing surgery: A multi- center prospective observational study
Authors: Demilie Atalay Eshetie , Denu Zewditu Abdissa , Bizuneh Yosef Belay , Gebremedhn Endale Gebreegziabher 
Published: August 2023

Abstract

Objective To determine incidence and factors associated with failed spinal anaesthesia among patients undergoing surgery in Amhara National Regional State comprehensive specialized hospitals, Northwest Ethiopia, 2023. Methods Multi-center prospective observational study was conducted. Data was collected using questionnaire and checklist. Data was transformed from Epi data to SPSS and logistic regression analysis was done. Both crude and adjusted odds ratio were used to assess the strength of association. Variables with a p-value of less than 0.05 were considered as statistically significant. Results A total of 532 patients were included in this study with a response rate of 98%. Incidence of failed spinal anaesthesia was 22.4% (CI = 19-25.9). Emergency surgery (AOR = 7.01, CI = 4.5–12.7), dose of bupivacaine of ≤ 10 mg (AOR = 3.02, CI = 1.3–10.2), work experience of anaesthetist < 2 years (AOR = 3.1, CI = 1.7–5.72), bloody CSF (AOR = 8.5, CI = 2.53–18.5), hyperbaric local anaesthetic drug (AOR = 3.3, 95% CI = 3.2–8.2) and local anaesthetist without adjuvants (AOR = 5.25, CI = 2.62–14.2) were associated failed spinal anaesthesia. Conclusion and recommendation: The incidence of failed spinal anaesthesia was high in Amhara Region comprehensive specialized hospitals. We suggest that anaesthesia providers should minimize failure by using adjuvants and appropriate dose of local anaesthetic. Additionally, simulation training should be given for anaesthesia trainees.
Treatment strategies for urinary tract infections based on fever
Authors: Yanagihara Takeshi , Kobayashi Koichi , Yanai Emi , Takeshita Hikaru , Tanabe Yujiro , Itoh Yasuhiko 
Published: August 2023

Abstract

Purpose
The duration of antimicrobial therapy for febrile urinary tract infections (fUTI) in children have not been established. This study aimed to explore the appropriate duration of the treatment for fUTI in children.
Methods
We created a protocol to determine the duration of antibiotic administration based on the fever. Transvenous antibiotics were administered for 3 days after the resolution of fever, followed by oral antibiotics for 1 week. Diagnosis of fUTI was based on a fever of 37.5°C or higher and a quantitative culture of catheterized urine showed ≥5 × 104 bacteria. Acute focal bacterial nephritis (AFBN) and pyelonephritis (PN) were diagnosed based on contrast-enhanced computed tomography (eCT) findings. We retrospectively reviewed the treatment outcomes.
Results
Of the 78 patients treated according to our protocol, 58 were included; 49 with PN (30 men) and nine with AFBN (three men). Blood test results showed that patients with AFBN had significantly higher white blood cell and C-reactive protein levels than those with PN; however, no differences were observed in the urinary findings and causative bacteria. The time to resolution of fever and duration of intravenous antibiotic administration were significantly longer in patients with AFBN than in those with PN. However, the average duration of AFBN treatment was 14.2 days, which was shorter than the previously reported 3-week administration and no recurrence was observed in AFBN patients.
Conclusions
The protocol created to determine the duration of antimicrobial treatment based on fever is useful. Invasive examinations, such as eCT, are not required.
Addressing Challenges in Diagnostic X-ray Dosimetry: Uncertainties and Corrections for Al2O3:C-based Optically Stimulated Luminescent Dosimeters
Authors: Wong Jeannie Hsiu Ding , Ismail Wan Hazlinda 
Published: August 2023

Abstract
The use of Al2O3:C-based optically stimulated luminescent dosimeters (OSLDs) in diagnostic X-ray is a challenge because of their energy dependence (ED) and variability of element sensitivity factors (ESFs). This study aims to develop a method to determine ED and ESFs of Landauer nanoDot™ OSLDs for clinical X-ray and investigate the uncertainties associated with ESFs. An area of 2 x 2 cm2 at the central axis of the X-ray field was used to establish the ESFs. A total of 80 OSLDs were categorized into “controlled” (n = 40) and “less-controlled” groups (n = 40). The ESFs of the OSLDs were determined using an 80 kVp X-ray in free-air geometry. The OSLDs were cross-calibrated with an ion chamber to establish the average calibration coefficient and ESFs. The OSLDs were then irradiated at tube potentials ranging from 50 to 150 kVp to determine their ED. The uniformity of the X-ray field was ± 1.5% at 100 cm source-to-surface distance. The batch homogeneities of user-defined ESFs were 2.4% and 8.7% for controlled and less-controlled OSLDs, respectively. The ED of OSLDs ranged from 1.125 to 0.812 as tube potential increased from 50 kVp to 150 kVp. The total uncertainty of OSLDs, without ED correction, could be as high as 16%. After applying ESF and ED correction, the total uncertainties were reduced to 6.3% in controlled OLSDs and 11.6% in less-controlled ones. OSLDs corrected with user-defined ESF and ED can reduce the uncertainty of dose measurements in diagnostic X-ray, particularly in managing less-controlled OSLDs.
Concurrent analysis of genome and transcriptome in one single cell
Authors: Heid Johanna , Cutler Ronald , Lee Moonsook , Vijg Jan , Maslov Alexander Y. 
Published: August 2023

Abstract
Thus far, multiple techniques for single cell analysis have been developed, yet we lack a relatively simple tool to assess DNA and RNA from the same cell at whole-transcriptome and whole-genome depths. Here we present an updated method for physical separation of cytoplasmic RNA from the nuclei, which allows for simultaneous studies of DNA and RNA from the same single cell. The method consists of three steps – 1) immobilization of a single cell on solid substrate, 2) hypotonic lysis of immobilized single cell, and 3) separation of cytosol containing aqueous phase and immobilized nucleus. We found that DNA and RNA extracted from single cell using our approach is suitable for downstream sequencing-based applications. We demonstrated that the coverage of transcriptome and genome sequencing data obtained after DNA/RNA separation is similar to that observed without separation. We also showed that the separation procedure does not create any noticeable bias in observed mutational load or mutation spectra. Thus, our method can serve as a tool for simultaneous complex analysis of the genome and transcriptome, providing necessary information on the relationship between somatic mutations and the regulation of gene expression.