bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of rehabilitation interventions evaluated in common neurological conditions in improving participation outcomes: A systematic review
Authors: Kossi Oyéné , Raats Joke , Wellens Jonas , Duckaert Mathias , De Baets Stijn , Van de Velde Dominique , Feys Peter 
Published: July 2023

Objective Modern clinical rehabilitation practice aligned to the International Classification of Functioning, Disability and Health and the Convention on the Rights of Persons with Disabilities highlights the importance of attention to participation in the rehabilitation formulation. This systematic review investigates the efficacy of rehabilitation interventions evaluated in common neurological disorders reported to influence participation outcomes. Data sources PubMed, Web of Science and PsycINFO databases were searched from inception to 25 April 2023. Only randomised controlled trials were considered for inclusion. Review methods The data were extracted by two independent reviewers in the following categories: characteristics of the included study publications, description of intervention and outcome measures. Results A total of 1248 unique article records were identified through the databases. Twenty-eight randomized controlled trials were included with 15 publications having participation as a primary outcome measure. Articles were related to multiple sclerosis ( N = 4), spinal cord injury ( N = 2), stroke ( N = 16) and traumatic brain injury ( N = 6). Four publications showed significant differences in pre- and post-intervention within experimental groups. All four articles described participation as primary outcome measure. Conclusion There is a limited evidence of the identified rehabilitation interventions to improve participation in common neurological conditions. However, there was a paucity of articles involving individual with Parkinson's disease that met the inclusion criteria.
Fusion imaging versus ultrasound-guided percutaneous thermal ablation of liver cancer: a meta-analysis
Authors: Sheng Yangang , Sun Xueke , Sun Hongmei , Qi Jinyan , Li Hua , Luan Jiankui , Zhai Deyin 
Published: July 2023

Background Ultrasound-guided percutaneous thermal ablation has become an alternative treatment for small hepatocellular carcinoma (HCC). Recent evidence suggests that fusion imaging (FI) may improve the feasibility and efficacy of thermal ablation for HCC, while the clinical evidence remains limited. Purpose To compare FI versus ultrasound-guided thermal ablation for HCC. Material and Methods Relevant cohort or randomized controlled trials were found by searching Medline, Web of Science, Cochrane Library, and Embase. The pooling of results was performed using a random-effects model incorporating heterogeneity. Results In this meta-analysis, 15 studies involving 1472 patients (1831 tumors) for FI-guided ablation and 1380 patients (1864 tumors) for ultrasound-guided ablation were included. Pooled results showed that compared to conventional HCC ablation guided by ultrasound, the FI-guided procedure showed a similar technique efficacy rate (risk ratio [RR] = 1.01, 95% confidence interval [CI] = 1.00–1.02, P = 0.25; I2 = 30%). However, FI-guided tumor ablation was associated with a lower incidence of overall complications (RR = 0.70, 95% CI = 0.50–0.97, P = 0.03; I2 = 0%). Moreover, patients receiving FI-guided tumor ablation had a lower risk of local tumor progression during follow-up than those with ultrasound-guided ablation (RR = 0.61, 95% CI = 0.47–0.78, P < 0.001; I2 = 13%). Subgroup analysis according to FI strategy, imaging techniques in controls, and tumor diameter showed consistent results (p for subgroup difference all >0.05). Conclusion FI-guided thermal ablation may be more effective and safer than ultrasound-guided ablation for patients with HCC.
Short-term dynamics of pride and state self-esteem change during the university-to-work transition
Authors: Diwan Ketaki A , Chung Joanne M , Meyers Christina , van Doeselaar Lotte , Reitz Anne K 
Published: July 2023

Young adults differ in their self-esteem change during the university-to-work transition. The short-term processes (such as state changes) which are related to individual variability in change are not yet fully understood. In this pre-registered study, we examined experiences of pride as an emotional process underlying state self-esteem change in a sample of 232 Dutch master students over 8 months across their university-to-work transition. We used dynamic and multilevel structural equation models to analyze three waves of 14-day experience sampling data, examining momentary and daily associations between pride and state self-esteem on the within-person level. We examined correlated change in pride and state self-esteem, and the extent to which pride predicted variability in state self-esteem change. Results indicated positive within-person associations and considerable individual differences in pride–state self-esteem associations across moments and days. Across months, changes in pride and state self-esteem were positively correlated, but pride before graduation did not predict variability in later state self-esteem change. Pride–state self-esteem associations remained robust after accounting for feelings of joy, transitional valence, and timing of the transition. Findings indicated that pride uniquely predicted state self-esteem change during the education-to-work transition, which suggests that pride is a key emotion underlying self-esteem change.
Thermoplastic starch hybrid biocomposite films with improved strength and flexibility produced through crosslinking via carboxylic acid
Authors: Lai Di Sheng , Osman Azlin Fazlina , Adnan Sinar Arzuria , Ibrahim Ismail , Ahmad Salimi Midhat Nabil , @ Mustapha Mariatti Jaafar 
Published: July 2023

Thermoplastic starch (TPS) suffers from its intrinsic low mechanical strength and high brittleness due to its strong hydrogen bonding and low chain mobility. The conventional way to crosslink the TPS film can improve the strength and stiffness of the films, but usually reduces the flexibility of the film, and increases its brittleness. In this study, the incorporation of the hybrid nanofiller [1 wt% nanocellulose (C) and 4 wt% nano bentonite (B)] into the TPS proved to improve greatly the films’ strength and flexibility. The hybrid nanofillers with ratio 4B:1C was incorporated into the crosslinked thermoplastic corn starch (CR-TPCS) film to increase the its flexibility and toughness and produced a high mechanical strength fully biodegradable film. Two different aqueous carboxylic acids: citric acid (CA) and tartaric acid (TA) with different pH values (2,4,6) as the green crosslinker were employed. Substantial increase of tensile strength (3.98 to 9.17 MPa), Young’s modulus (9.10 to 46.30 MPa) and elongation at break (55.2 to 135.7%) was observed for the CA- 4B1C/pH2 films compared to the CR-TPCS films. The melting temperature (Tm) of the CA-4B1C/pH2 improved compared to the TPCS/4B1C (un-crosslinked) film due to its crosslinking effect. Meanwhile, the CA-4B1C films exhibited the highest degree of substitution and di-esterification with the lowest swelling and water solubility properties due to the formation of a special “bridge” structure between the CA, nanocellulose and plasticizer. The “bridge” structure developed between the TPCS chains serves as the toughener to motivate higher chain stress relaxation and load endurance. The crosslinked “bridge structure” also proved to effectively reduce the retrogradation phenomenal in the TPCS films. This combination method of hybridization and crosslinking is an efficient, low cost, and environmentally friendly technique to overcome the low flexibility and brittleness problem of the TPS based packaging film.
Reduction of emissions and improvement of dynamic responses of a supercritical clean coal generation unit via neural network inverse control strategy
Authors: Mohamed Omar 
Published: July 2023

Coal power plants have been a major source of undesirable emissions. Despite the technological advancements in renewable energies, coal units are still in-service in many developed and developing countries due to their reliability, adequacy, and flexibility for power delivery. There are some promising technologies for cleaner operation during power production from coal, including supercritical boiler (SC) design and carbon capture and storage (CCS), however, the challenging in innovating effective methods is still open to expand the boundary of knowledge in this speciality. This paper introduces a novel and simple method for reducing CO2 emissions and improving the dynamic responses of a 600 MW SC coal power plant by Artificial Neural Network (ANN) technique. A wide-range data-driven feedforward ANN model has been identified and verified for the various operations recorded as closed-loop data-sets, which covers all situations of startup, once-through mode, and even emergency shutdown of the unit. The closed-loop SC plant model has been augmented with an inverse multivariable coordinate NN controller, developed by analogous learning algorithm to improve the plant automation. With precisely selected setpoints, as operational rules, of temperature, pressure, and earliest possible power demand signals, the automated SC plant has been capable to operate with lower coal consumption - and thus lower emissions – than the existing operation strategy during startup, normal operation, and emergency shutdown modes. The improvement in dynamic responses have been quantified through simulations with comparison with existing performance, which have resulted in an overall average reduction of 2.143 Kg/s in coal consumption.
Variation in outpatient consultation fees of psychiatrists in Australia by state and territory
Authors: Coulston Caitlin , Leahey James 
Published: July 2023

Objective To determine bulk billing rates, and mean, median, and 10th and 90th centile fees for outpatient consultations with a psychiatrist in Australia in 2019, by state or territory. Method Medicare claims data for bulk billing rates and the mean, median, and 10th and 90th centile for fees charged in Australia in 2019 were requested, for item numbers for initial and ongoing consultations. Results There were high rates of bulk billing overall. Initial consultations were more likely to be bulk billed. There was variation in fees between states and territories. Fees were highest in the Australian Capital Territory. Conclusion There is variation in fees and bulk billing rates for outpatient consultations with a psychiatrist. Fees tend to be higher in states or territories with higher median personal income. Psychiatrists were more likely to bulk bill for initial consultations, with the exception of the Northern Territory. High rates of bulk billing may indicate psychiatrists are absorbing increasing costs of service provision.
A retrospective, real-life analysis of metronomic oral single-agent cyclophosphamide for the treatment of platinum-pretreated advanced ovarian carcinoma in Italy
Authors: Gebbia Vittorio , Martorana Federica , Scandurra Giuseppina , Valerio Maria Rosaria , Cufari Salvatore , Vigneri Paolo , Sanò Maria Vita , Scollo Paolo 
Published: July 2023

Introduction Metronomic oral cyclophosphamide (MOC) presents many potential advantages, such as significantly less severe side effects than standard regimens, ease of administration, and the delivery of a dose-dense but not necessarily dose-intense treatment. These observations prompted us to evaluate in a retrospective, multicenter study the efficacy and toxicity of MOC in a real-life series of pretreated cancer patients. Methods The study is a multicenter, retrospective analysis of the activity of single-agent MOC in patients with recurrent or residual epithelial ovarian, fallopian tube, or primary. Eligible patients were continuously treated with MOC at 50 mg/day until progression, toxicity, or death. Overall response rate (ORR), stable disease (SD), and disease control rate (DCR) were reported. Results The study included 62 patients. Three patients reached a complete response rate (5%), 11 had a partial response rate (18), and 15 had stabilization of disease (24) for an ORR of 23% and a DCR of 47%. Patients with low-grade indolent tumors showed an ORR and an SD rate higher than that observed in non-indolent ones (33% vs. 18% and 28% vs. 14%, respectively). Overall, progression-free survival was 3.5 months (range 1–9 months). Conclusion Single-agent MOC is active and very well tolerated in a significant fraction of patients with refractory, recurrent, or residual epithelial ovarian, fallopian tube, or primary peritoneal cancer. In the vision of a practical approach, single-agent MOC may be a useful palliative treatment option for patients with poor tolerance to high-dose regimens or widely pretreated. Further studies are needed better to characterize the role of such an approach in clinical practice.
The deep learning algorithm estimates chest radiograph-based sex and age as independent risk factors for future cardiovascular outcomes
Authors: Liao Hao-Chun , Lin Chin , Wang Chih-Hung , Fang Wen-Hui 
Published: July 2023

Objectives Chest X-rays (CXRs) convey much illegible physiological information that deep learning model (DLM) has been reported interpreting successfully. Since the electrocardiogram age established by DLM was revealed as a heart biological marker, we hypothesize that CXR age has similar potential to describe the heart and lung states. Therefore, we developed a DLM to predict sex and age through CXR and analyzed its relation with future cardiovascular diseases (CVD). Methods A total of 90,396 CXRs aged 20 to 90 were collected and separated into a development set with 53,102 CXRs and demographic information pairs, a tuning set with 7073 pairs, an internal validation set with 17,364 pairs, and an external validation set with 12,857 pairs. The study trained DLM with development set for estimating age and sex and compared them to actual information. Results The mean absolute errors of predicted age were 4.803 and 4.313 years in the internal and external validation sets, respectively. The area under the curve of sex analysis was 0.9993 and 0.9988 in the internal and external validation sets, respectively. Patients whose CXR age was 5 years older than chronologic age lead to higher risk of all-cause mortality (hazard ratio (HR): 2.42, 95% confidence interval (CI): 2.00–2.92), cardiovascular (CV)-cause mortality (HR: 7.57, 95% CI: 4.55–12.60), new-onset heart failure (HR: 2.07, 95% CI: 1.56–2.76), new-onset chronic kidney disease (HR: 1.73, 95% CI: 1.46–2.05), new-onset acute myocardial infarction (HR: 1.80, 95% CI: 1.12–2.92), new-onset stroke (HR: 1.45, 95% CI: 1.10–1.90), new-onset coronary artery disease (HR: 1.26, 95% CI: 1.04–1.52), and new-onset atrial fibrillation (HR: 1.43, 95% CI: 1.01–2.02). Conclusions Using DLM to predict CXR age provided additional information for future CVDs. Older CXR age is an accessible risk classification tool for clinician use.
Longitudinal Predictors of PROMIS Satisfaction With Social Roles and Activities After Shoulder and Knee Sports Orthopaedic Surgery in United States Military Servicemembers: An Observational Study
Authors: Highland Krista B. , Kent Michael , McNiffe Nicholas , Patzkowski Jeanne C. , Patzkowski Michael S. , Kane Alexandra , Giordano Nicholas A. 
Published: July 2023

Background: Satisfaction with social roles and activities is an important outcome for postsurgical rehabilitation and quality of life but not commonly assessed. Purpose: To evaluate longitudinal patterns of the Patient-Reported Outcomes Measurement Information System (PROMIS) Satisfaction with Social Roles and Activities measure, including how it relates to other biopsychosocial factors, before and up to 6 months after sports-related orthopaedic surgery. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: Participants (N = 223) who underwent knee and shoulder sports orthopaedic surgeries between August 2016 and October 2020 completed PROMIS computer-adaptive testing item banks and pain-related measures before surgery and at 6-week, 3-month, and 6-month follow-ups. In a generalized additive mixed model, covariates included time point; peripheral nerve block; the PROMIS Anxiety, Sleep Disturbance, and Pain Behavior measures; and previous 24-hour pain intensity. Patient-reported outcomes were modeled as nonlinear (smoothed) effects. Results: The linear (estimate, 2.06; 95% CI, 0.77-3.35; P = .002) and quadratic (estimate, 2.93; 95% CI, 1.78-4.08; P < .001) effects of time, as well the nonlinear effects of PROMIS Anxiety ( P < .001), PROMIS Sleep Disturbance ( P < .001), PROMIS Pain Behavior ( P < .001), and pain intensity ( P = .02), were significantly associated with PROMIS Satisfaction with Social Roles and Activities. The cubic effect of time ( P = .06) and peripheral nerve block ( P = .28) were not. The proportion of patients with a 0.5-SD improvement in the primary outcome increased from 23% at 6 weeks to 52% by 6 months postsurgery, whereas those reporting worsening PROMIS Satisfaction with Social Roles and Activities decreased from 30% at 6 weeks to 13% at 6 months. Conclusion: The PROMIS Satisfaction with Social Roles and Activities measure was found to be related to additional domains of function (eg, mental health, behavioral, pain) associated with postsurgical rehabilitation.
Asynchronous conferencing through a secure messaging application increases reporting of medical errors in a mature trauma center
Authors: Lee Joy L , Isenberg Scott , Adams Georgann , Thurston Maria , Hammer Peter M , Mohanty Sanjay K , Jenkins Peter C 
Published: July 2023

Background Medical errors occur frequently, yet they are often underreported and strategies to increase the reporting of medical errors are lacking. In this work, we detail how a Level 1 trauma center used a secure messaging application to track medical errors and enhance its quality improvement initiatives. Methods We describe the formulation, implementation, evolution, and evaluation of a chatroom integrated into a secure texting system to identify performance improvement and patient safety (PIPS) concerns. For evaluation, we used descriptive statistics to examine PIPS reporting by the reporting method over time, the incidence of mortality and unplanned ICU readmissions tracked in the hospital trauma registry over the same, and time-to-loop closure over the study period to quantify the impact of the processes instituted by the PIPS team. We also categorized themes of reported events. Results With the implementation of a PIPS chatroom, the number of events reported each month increased and texting became the predominant way for users to report trauma PIPS events. This increase in PIPS reporting did not appear to be accompanied by an increase in mortality and unplanned ICU readmissions. The PIPS team also improved the tracking and timely resolution of PIPS events and observed a decrease in time-to-loop closure with the implementation of the PIPS chatroom. Conclusions The adoption of clinical texting as a way to report PIPS events was associated with increased reporting of such events and more timely resolution of concerns regarding patient safety and healthcare quality.
Prevalence and significance of DDX41 gene variants in the general population
Authors: Cheloor Kovilakam Sruthi , Gu Muxin , Dunn William G. , Marando Ludovica , Barcena Clea , Nik-Zainal Serena , Mohorianu Irina , Kar Siddhartha P. , Fabre Margarete A. , Quiros Pedro M. , Vassiliou George S. 
Published: July 2023

Abstract
Germ line variants in the DDX41 gene have been linked to myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) development. However, the risks associated with different variants remain unknown, as do the basis of their leukemogenic properties, impact on steady-state hematopoiesis, and links to other cancers. Here, we investigate the frequency and significance of DDX41 variants in 454 792 United Kingdom Biobank (UKB) participants and identify 452 unique nonsynonymous DNA variants in 3538 (1/129) individuals. Many were novel, and the prevalence of most varied markedly by ancestry. Among the 1059 individuals with germ line pathogenic variants (DDX41-GPV) 34 developed MDS/AML (odds ratio, 12.3 vs noncarriers). Of these, 7 of 218 had start-lost, 22 of 584 had truncating, and 5 of 257 had missense (odds ratios: 12.9, 15.1, and 7.5, respectively). Using multivariate logistic regression, we found significant associations of DDX41-GPV with MDS, AML, and family history of leukemia but not lymphoma, myeloproliferative neoplasms, or other cancers. We also report that DDX41-GPV carriers do not have an increased prevalence of clonal hematopoiesis (CH). In fact, CH was significantly more common before sporadic vs DDX41-mutant MDS/AML, revealing distinct evolutionary paths. Furthermore, somatic mutation rates did not differ between sporadic and DDX41-mutant AML genomes, ruling out genomic instability as a driver of the latter. Finally, we found that higher mean red cell volume (MCV) and somatic DDX41 mutations in blood DNA identify DDX41-GPV carriers at increased MDS/AML risk. Collectively, our findings give new insights into the prevalence and cognate risks associated with DDX41 variants, as well as the clonal evolution and early detection of DDX41-mutant MDS/AML.
Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors
Authors: Mobbs Jesse I. , Black Katrina A. , Tran Michelle , Burger Wessel A. C. , Venugopal Hariprasad , Holman Theodore R. , Holinstat Michael , Thal David M. , Glukhova Alisa 
Published: July 2023

Abstract
Human 12-lipoxygenase (12-LOX) is a key enzyme involved in platelet activation, and the regulation of its activity has been targeted for the treatment of heparin-induced thrombocytopenia. Despite the clinical importance of 12-LOX, the exact mechanisms by which it affects platelet activation are not fully understood, and the lack of structural information has limited drug discovery efforts. In this study, we used single-particle cryo-electron microscopy to determine high-resolution structures (1.7-2.8 Å) of human 12-LOX. Our results showed that 12-LOX can exist in multiple oligomeric states, from monomer to hexamer, which may affect its catalytic activity and membrane association. We also identified different conformations within the 12-LOX dimer, which likely represent different time points in its catalytic cycle. Furthermore, we identified small molecules bound to 12-LOX. The active site of the 12-LOX tetramer was occupied by an endogenous 12-LOX inhibitor, a long-chain acyl coenzyme A. In addition, we found that the 12-LOX hexamer can simultaneously bind to arachidonic acid and ML355, a selective 12-LOX inhibitor that has passed a phase 1 clinical trial for the treatment of heparin-induced thrombocytopenia and received a fast-track designation by the Food and Drug Administration. Overall, our findings provide novel insights into the assembly of 12-LOX oligomers, their catalytic mechanism, and small molecule binding, paving the way for further drug development targeting the 12-LOX enzyme.