bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microwave‐Assisted Syntheses of Rhodamine, Rhodol, and Fluorescein Derivatives
Authors: Chieffo Carolina , Altamura Emiliano , Pilet Guillaume , Mebarek Saida , Strazewski Peter , Fiore Michele 
Published: July 2023

AbstractA series of rhodol‐; fluorescein‐ and rhodamines‐based spirolactam compounds, bearing electron donor amines have been prepared. For this purpose we have redesigned the synthesis of the rhodol scaffold using 2‐(2,4‐dihydroxybenzoyl)benzoic acid obtaining one example rhodol methyl ester in good yields (25–30 %) Thus, one set of non‐cytotoxic rhodamine‐based compounds has been prepared using thermal and microwave assisted synthesis (40–78 %) and tested as high affinity ATP chemo‐sensors.
Synthesis of 2,6‐Dimethoxy‐p‐aminophenol from Hardwood Lignin
Authors: Bai Jing , Li Hao , Zhu Yuting , Zhu Yiping , Wang Chenguang , Wang Haiyong , Liao Yuhe 
Published: July 2023

AbstractAlthough the multiple functional groups in biomass offer notable chances for producing high‐value chemicals, most of the current studies focused on the (deep) defunctionalization of biomass and its derivates. Herein, we present a catalytic approach to valorize birch wood lignin with maintaining the methoxy and hydroxy groups in the final product (i. e., 2,6‐dimethoxy‐p‐aminophenol), which has applications in different sectors such as pharmaceuticals. The proved approach involves four steps with a high yield (19.8 wt % on the basis of used lignin) to 2,6‐dimethoxy‐p‐aminophenol. The native lignin in birch wood was first converted using alkaline aerobic oxidation in the presence of copper ions toward high‐yield syringaldehyde, which was then selectively oxidized toward 2,6‐dimethoxy‐1,4‐benzoquinone using H2O2 and V2O5. Oximation of 2,6‐dimethoxy‐1,4‐benzoquinone can selectively form 2,6‐dimethoxy‐1,4‐benzoquinone‐4‐oxime, which can be quantitatively hydrogenated toward 2,6‐dimethoxy‐p‐aminophenol. This work highlights the unique potential of biomass and its derivates for the sustainable production of high‐value products with exploring the value of inherent functional groups.
Preventive putative effect of agmatine on cognitive and molecular outcomes in ventral tegmental area of male offspring following physical and psychological prenatal stress
Authors: Hassanshahi Amin , Janahmadi Mahyar , Razavinasab Moazamehosadat , Ranjbar Hoda , Hosseinmardi Narges , Behzadi Gila , Kohlmeier Kristi A. , Ilaghi Mehran , Shabani Mohammad 
Published: July 2023

AbstractPrenatal stress (PS) results from a maternal experience of stressful events during pregnancy, which has been associated with an increased risk of behavioral disorders including substance abuse and anxiety in the offspring. PS is known to result in heightened dopamine release in the ventral tegmental area (VTA), in part through the effects of corticotropin‐releasing hormone, which directly excites dopaminergic cells. It has recently been suggested that agmatine plays a role in modulating anxiety‐like behaviors. In this study, we investigated whether agmatine could reduce negative cognitive outcomes in male mice prenatally exposed to psychological/physical stress, and whether this could be associated with molecular changes in VTA. Agmatine (37.5 mg/kg) was administrated 30 min prior to PS induction in pregnant Swiss mice. Male offspring were evaluated in a series of behavioral and molecular assays. Findings demonstrated that agmatine reduced the impairment in locomotor activity induced by both psychological and physical PS. Agmatine also decreased heightened conditioned place preference to morphine seen in PS offspring. Moreover, agmatine ameliorated the anxiety‐like behavior and drug‐seeking behavior induced by PS in the male offspring. Molecular effects were seen in VTA as the enhanced brain‐derived neurotrophic factor (BDNF) induced by PS in the VTA was reduced by agmatine. Behavioral tests indicate that agmatine exerts a protective effect on PS‐induced impairments in male offspring, which could be due in part to agmatine‐associated molecular alterations in the VTA. Taken together, our data suggest that prenatal treatment with agmatine exerts protective effect against negative consequences of PS on the development of affective circuits in the offspring.
The effects of forced exercise and zinc supplementation during pregnancy on prenatally stress‐induced behavioral and neurobiological consequences in adolescent female rat offspring
Authors: Sameei Parsa , Fatehfar Sina , Abdollahzadeh Naseh , Chodari Leila , Saboory Ehsan , Roshan‐Milani Shiva 
Published: July 2023

AbstractPrenatal manipulations can lead to neurobehavioral changes in the offspring. In this study, individual and combined effects of forced exercise and zinc supplementation during pregnancy on prenatally restraint stress (PRS)‐induced behavioral impairments, neuro‐inflammatory responses, and oxidative stress have been investigated in adolescent female rat offspring. Pregnant rats were divided into five groups: control; restraint stress (RS); RS + exercise stress (RS + ES), RS + zinc supplementation (RS + Zn); and RS + ES + Zn. All the pregnant rats (except control) were exposed to RS from gestational days 15 to 19. Pregnant rats in ES groups were subjected to forced treadmill exercise (30 min/daily), and in Zn groups to zinc sulfate (30 mg/kg/orally), throughout the pregnancy. At postnatal days 25–27, anxiety‐like and stress‐coping behaviors were recorded, and the gene expressions of interleukin‐1β (IL‐1β) and tumor necrosis factor‐α (TNF‐α) and the concentration of total antioxidant capacity were measured in the prefrontal cortex. PRS significantly enhanced anxiety, generated passive coping behaviors, increased IL‐1β and TNF‐α expression, and decreased the antioxidant capacity. ES potentiated while zinc reversed PRS‐induced behavioral impairments. Prenatal zinc also restored the anti‐inflammatory and antioxidant capacity but had no effect on additive responses imposed by the combination of RS and ES. Suppression of PRS‐induced behavioral and neurobiological impairments by zinc suggests the probable clinical importance of zinc on PRS‐induced changes on child temperament.
Two tropical seagrass species show differing indicators of resistance to a marine heatwave
Authors: Bass Alissa V. , Falkenberg Laura J. 
Published: July 2023

AbstractMarine heatwaves (MHWs) are a growing threat to marine species globally, including economically and ecologically important foundation species, such as seagrasses. Seagrasses in tropical regions may already be near their thermal maxima, and, therefore, particularly susceptible to increases in temperature, such as from MHWs. Here, we conducted a 10‐day MHW experiment (control +4°C) to determine the effects of such events on the two tropical seagrasses Halophila beccarii and Halophila ovalis. We found that both species were largely resistant to the MHW, however, there were differences between the species' responses. For H. beccarii, the surface area of existing leaves was smaller under MHW conditions, yet a substantial increase in the number of new leaves under the MHW indicated its tolerance to—or even increased performance under—the MHW. While there was no direct effect of the MHW on H. ovalis, this species saw less epiphyte biomass and percentage cover on its leaves under the MHW. While a lower epiphyte cover can potentially increase the health and ecophysiological performance of the seagrass, the change of epiphytes can lead to bottom‐up trophic implications via the influence on mesograzer feeding. Together, the results of this study demonstrate the species‐specific responses of seagrasses of the same genus to a warming event. With the current global decline of seagrasses, our results are encouraging for these important habitat formers as we show that anomalous warming events may not necessarily lead to ecosystem collapse.
Reciprocal transplants reveal asymmetric local adaptation of Himalayan Rhododendron approaching elevational range limit
Authors: Mainali Kumar , Adhikari Subodh , Shrestha Sushila , Singer Michael C. , White Joseph , Parmesan Camille 
Published: July 2023

AbstractAs plant species expand their upper limits of distribution under current warming, some retain both traditional climate space and biotic environment while others encounter novel conditions. The latter is the case for Rhododendron campanulatum, a woody shrub that grows both above and below treeline at our study site in the Eastern Himalayas where a very conspicuous, stable treeline was defined by a nearly contiguous canopy of tall Abies spectabilis trees, many of which are over a century old. Prior work showed that treeline had remained static in this region while R. campanulatum expanded its elevational range limit. We tested local adaptation of R. campanulatum by performing reciprocal transplants between the species' current elevational range limit (4023 m above sea level [asl]) and just above treeline (3876 m asl). Contrary to expectation, the coldest temperatures of late winter and early mid‐spring were experienced by plants at the lower elevation: R. campanulatum at species' limit (upper site) were covered by snow for a longer period (40 more days) and escaped the coldest temperatures suffered by conspecifics at treeline (lower site). The harsher spring conditions at treeline likely explain why leaves were smaller at treeline (15.3 cm2) than at species limit (21.3 cm2). Contrary to results from equivalent studies in other regions, survival was reduced more by downslope than by upslope movement, again potentially due to extreme cold temperatures observed at treeline in spring. Upslope transplantation had no effect on mortality, but mortality of species limit saplings transplanted downslope was three times higher than that of residents at both sites. A general expectation is that locals should survive better than foreign transplants, but survival of locals and immigrants at our species limit site was identical. However, those species limit saplings that survived the transplant to treeline grew faster than both locals at treeline and the transplants at species limit. Overall, we found asymmetric adaptation: Compared with treeline saplings, those at species limit (147 m above treeline) were more tolerant of extremes in the growing season but less tolerant of extremes in winter and early mid‐spring, displaying local adaptation in a more complex manner than simply home advantage, and complicating predictions about impacts of future regional climate change.
Optimization of jujube peel pigment multivesicular liposome formulation and evaluation of the protective effect on UVB‐induced photodamage
Authors: Liu Zhiming , Zheng Ying , Yue Bowen , Luo Yali , Cao Zhaoxin , Su Jingyi , Wang Xinyu , Zhang Yan , Zhang Yifei , Wang Bingxue , Cheng Xiaoliang , Zhou Zhiyong , Ge Xuemei 
Published: July 2023

AbstractJujube peel pigment (JP), an ideal natural water‐soluble pigment extracted from jujube peel, mainly consists of flavonoids and possesses a wide range of physiological activities. In this study, JP‐loaded multivesicular liposomes (JP‐MVL) were prepared using the double emulsification method. JP‐MVL was characterized, and its encapsulation efficiency was determined using the UV‐Vis method. Furthermore, the release behavior and antioxidant capacity of JP‐MVL were evaluated in vitro. The results displayed in the structure of JP‐MVL were spherical with internal vesicles; the average particle size of JP‐MVL was 5.63 μm, and the zeta potential was −69.50 mV. Analysis of the release results indicated that the best‐fitting models in PBS (Phosphate buffered saline pH 7.4) and 0.9% NaCl were the Higuchi and first‐order kinetic models, respectively. The cytotoxicity of JP‐MVL at the appropriate concentrations was negligible and had a good protective effect against UVB‐induced photodamage.
Deconstructing Eurocentrism in skin pigmentation research via the incorporation of diverse populations and theoretical perspectives
Authors: Pryor Yemko , Lindo John 
Published: July 2023

AbstractThe evolution of skin pigmentation has been shaped by numerous biological and cultural shifts throughout human history. Vitamin D is considered a driver of depigmentation evolution in humans, given the deleterious health effects associated with vitamin D deficiency, which is often shaped by cultural factors. New advancements in genomics and epigenomics have opened the door to a deeper exploration of skin pigmentation evolution in both contemporary and ancient populations. Data from ancient Europeans has offered great context to the spread of depigmentation alleles via the evaluation of migration events and cultural shifts that occurred during the Neolithic. However, novel insights can further be gained via the inclusion of diverse ancient and contemporary populations. Here we present on how potential biases and limitations in skin pigmentation research can be overcome with the integration of interdisciplinary data that includes both cultural and biological elements, which have shaped the evolutionary history of skin pigmentation in humans.
Harvesting the volatility smile in a large emerging market: A Dynamic Nelson–Siegel approach
Authors: Kumar Sudarshan , Agarwalla Sobhesh Kumar , Varma Jayanth R. , Virmani Vineet 
Published: July 2023

AbstractWhile there is a large literature on modeling volatility smile in options markets, most such studies are eventually focused on the forecasting performance of the model parameters and not on the applicability of the models in a trading environment. Drawing on the analogy of volatility smile like a term structure in the context of interest rates in fixed‐income markets, we evaluate the performance of the Dynamic Nelson–Siegel (DNS) approach to modeling the dynamics of volatility smile in a trading environment against competing alternatives. Using model‐based mispricing as our sorting criterion, and deploying a trading strategy of going long the options in the upper deciles and going short the options in the lower deciles, we show that dynamic models consistently outperform their static counterparts, with the worst dynamic model outperforming the best static model in terms of the percentage of mean returns from the trading portfolios and the Sharpe ratio. Specifically, we find that the DNS model consistently outperforms all other competing specifications on most of our selected criteria.
Refined cytogenetic IPSS‐R evaluation by the use of SNP array in a cohort of 290 MDS patients
Authors: Scarpelli Ilaria , Stalder Valérie Beyer , Tsilimidos Gerasimos , Rapakko Katrin , Costanza Mariangela , Blum Sabine , Schoumans Jacqueline 
Published: July 2023

AbstractGenetic testing plays a central role in myelodysplastic neoplasms (MDS) diagnosis, prognosis, and therapeutic decisions. The widely applied cytogenetic revised international prognostic scoring system (IPSS‐R) was based on chromosome banding analysis (CBA). However, subsequently developed genetic methodologies, such as single nucleotide polymorphism (SNP) array, demonstrated to be a valid alternative test for MDS. SNP array is, in fact, able to detect the majority of MDS‐associated cytogenetic aberrations, by providing further genomic information due to its higher resolution. In this study, 290 samples from individuals with a confirmed or suspected diagnosis of MDS were tested by both CBA and SNP array, in order to evaluate and compare their cytogenetic IPSS‐R score in the largest MDS cohort reported so far. A concordant or better refined cytogenetic IPSS‐R array‐based score was obtained for 95% of cases (277). Therefore, this study confirms the effective applicability of SNP array toward the cytogenetic IPSS‐R evaluation and consequently, toward the molecular international prognostic scoring system for MDS (IPSS‐M) assessment, which ensures an improved MDS risk stratification refinement. Considering the advent of additional genetic technologies interrogating the whole genome with increased resolutions, counting cytogenetic abnormalities based on their size may result in a simplistic approach. On the contrary, assessing overall genomic complexity may provide additional crucial information. Independently of the technology used, genetic results should indeed aim at ensuring a highly refined stratification for MDS patients.
Current status of sinonasal cancer survivorship care
Authors: Han Albert Y. , Nader Marc‐Elie , Lam Keng , Su Shirley Y. 
Published: July 2023

AbstractSinonasal cancer is a heterogeneous orphan disease of diverse histologies, each with distinct clinical, oncologic, and toxicity profiles. Because of the comparative rarity of these cancers, sinonasal cancers are treated as a grouped diagnosis despite their clinical and biological heterogeneity. Multimodality treatment with a combination of surgery, chemotherapy, and/or radiotherapy is the standard‐of‐care for advanced‐stage patients but there are few surveillance or follow‐up practice guidelines or formalized survivorship care pathways. A scoping literature review was conducted via PubMed, EMBASE, and Google Scholar. A total of 112 studies were included, which were grouped along the following topics: surveillance, second primary tumors, quality of life, and symptom burden. Sinonasal cancer tends to exhibit a higher rate of local failure and occur in a delayed fashion compared to mucosal malignancies of the head and neck. Moreover, the site of failure and time‐varying risk of recurrence is histology‐specific. Following multimodality treatment of the skull base, patients may experience endocrine, visual, auditory, sinonasal, olfactory, and neurocognitive deficits, as well as psychosocial impairments that impact multiple physical and neuropsychological domains, resulting in diminished quality of life. Sinonasal cancer patients would benefit from tailored, histology‐specific survivorship programs to address the recurrence, second primary, and functional impairments resulting from disease and treatment toxicity.
BAG3: An enticing therapeutic target for idiopathic pulmonary fibrosis
Authors: Chillappagari Shashipavan , Guenther Andreas , Mahavadi Poornima 
Published: July 2023

AbstractIdiopathic pulmonary fibrosis (IPF) is a dreadful and fatal disease of unknown etiology, for which no cure exists. Autophagy, a lysosomal cellular surveillance pathway is insufficiently activated in both alveolar epithelial type II cells and fibroblasts of IPF patient lungs. Fine‐tuning this pathway may result in the degradation of the accumulated cargo and influence cell fate. Based on our previous data, we here present our view on modulating autophagy via a unique co‐chaperone, namely Bcl2‐associated athanogene3 (BAG3) in IPF and discuss about how repurposing drugs that modulate this pathway may emerge as a promising novel therapeutic approach for IPF.
Totally symmetric quasigroups of order 16
Authors: Ginsberg Hy 
Published: July 2023

AbstractWe present the number of totally symmetric quasigroups (equivalently, totally symmetric Latin squares) of order 16, as well as the number of isomorphism classes of such objects. Totally symmetric quasigroups of orders up to and including 16 that are (respectively) medial, idempotent, and unipotent are also enumerated.
Patterns of morphological variation and ecological correlates in the skull of vipers (Serpentes: Viperidae)
Authors: Carrasco Paola A. , Prystupczuk Lilen , Koch Claudia , González Germán A. , Leynaud Gerardo C. , Grazziotin Felipe G. 
Published: July 2023

AbstractThe skull of vipers is a highly kinetic anatomical structure involved in envenomating and consuming of prey. Morphological knowledge about the viperid skull is based on studies on some groups of species, but information on its variation within the whole family and its functional morphology is still scarce. In this study, we aimed to explore variation in skull morphology among species of the three subfamilies of Viperidae, and test whether that variation correlates with macrohabitat and diet. We performed quantitative analyses of the viperid skull based on broad taxonomic sampling and two methodological approaches: linear and geometric morphometrics. The results of both approaches showed that much of the variation lies in differences of shape and relative size of the premaxilla, the nasals, the frontals, and the parietals. The results indicated that phylogeny and size influence the shape of the skull, but we also found evidence of morphological differentiation between arboreal and terrestrial species and in species with mammal specialist diet. Our findings imply that, besides evolutionary allometry and phylogenetic signal, demands of particular diets coupled with use of certain habitats have in part shaped morphological evolution of the viperid skull.
The impact of body mass index on oncoplastic breast surgery: A multicenter analysis
Authors: De La Cruz Ku Gabriel , Camarlinghi Madison , Mallouh Michael P. , Torres‐Roman J. Smith , Linshaw David , Persing Sarah M. , Nardello Salvatore , Chatterjee Abhishek 
Published: July 2023

AbstractBackgroundObesity has nearly tripled in the last 50 years. During the last decades, oncoplastic breast surgery has become an important choice in the surgical treatment of breast cancer. An association exists between higher body mass index (BMI) and wound complications for major operations, but there is scarce literature on oncoplastic surgery. Hence, our aim was to compare the complication rates among patients who underwent oncoplastic surgery, stratified by BMI.MethodsPatient data were analyzed from the National Surgical Quality Improvement Program database (NSQIP) for oncoplastic breast procedures (2005–2020). Patients were stratified according to World Health Organization obesity classifications. Multivariate logistic regression was performed to assess risk factors for complications (overall, operative, and wound‐related).ResultsFrom a total of 6887 patients who underwent oncoplastic surgery, 4229 patients were nonobese, 1380 had Class 1 obesity (BMI: 30 to <35 kg/m2), 737 Class 2 obesity (BMI: 35 to <40 kg/m2), and 541 Class 3 obesity (BMI: ≥ 40 kg/m2). Greater operative time was found according to higher BMI (p < 0.001). Multivariate analysis adjusted for baseline characteristics showed that patients with obesity Class 2 (odds ratio [OR] = 1.51, 95% confidence interval [CI]: 1.03–2.23, p = 0.037) and 3 (OR = 1.87, 95% CI 1.24–2.83, p = 0.003) had increased risk of overall and wound complications compared with Nonobese patients. Comparing obese with nonobese patients, there were no differences in rates of deep SSI, organ/space SSI, pneumonia, reintubation, pulmonary embolism, deep vein thrombosis, urinary tract infection, stroke, bleeding, postoperative sepsis, length of stay, and readmission.ConclusionsOncoplastic surgery is a safe procedure for most patients. However, caution should be exercised when performing oncoplastic surgery for patients with Class 2 or 3 obesity (BMI ≥ 35 kg/m2), given there was a higher rate of overall and wound‐specific complications, compared with patients who were not obese or had Class 1 obesity.