bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Best Scenario for Geostatistical Modeling of Porosity in the Sarvak Reservoir in an Iranian Oil Field, Using Electrofacies, Seismic Facies, and Seismic Attributes
Authors: Mehdipour Vali , Rabbani Ahmad Reza , Kadkhodaie Ali 
Published: July 2023

SummaryThe lateral and vertical variations in porosity significantly impact the reservoir quality and the volumetric calculations in heterogeneous reservoirs. With a case study from Iran’s Zagros Basin Sarvak reservoir in the Dezful Embayment, this paper aims to demonstrate an efficient methodology for distributing porosity. Four facies models (based on electrofacies analysis data and seismic facies) with different geostatistical algorithms were used to examine the effect of different facies types on porosity propagation. Both deterministic and stochastic methods are adopted to check the impact of geostatistical algorithms on porosity modeling in the static model. A total of 40 scenarios were run and validated for porosity distribution through a blind test procedure to check the reliability of the models. The study’s findings revealed high correlation values in the blind test data for all porosity realizations linked to seismic facies, ranging from 0.778 to 0.876. In addition, co-kriging to acoustic impedance (AI), as a secondary variable, increases the correlation coefficient in all related cases. Unlike deterministic algorithms, using stochastic methods reduces the uncertainty and causes the porosity model to have an identical histogram compared with the original data. This study introduced a comprehensive workflow for porosity distribution in the studied carbonate Sarvak reservoir, considering the electrofacies, and seismic facies, and applying different geostatistical algorithms. As a result, based on this workflow, simultaneously linking the porosity distribution to seismic facies, co-kriging to AI, and applying the sequential Gaussian simulation (SGS) algorithm result in the best spatial modeling of porosity.
A New Approach for the Relationship Between the Contact Stiffness and the Interference of Journal and Bearing Shrink-Fitted
Authors: Jin Lan , Rui zhiyuan , Li weibing , Zhao guoxing 
Published: July 2023

Abstract
Shrink-fit connections often experience detachment of the contact surface as speed increases, resulting in a separation distance that determines the interference fit. This study proposes a new approach to investigate the relationship between contact stiffness at the microscale and macroscopic interference in shrink-fit connections between the journal and bearing of high-speed spindles. A model for contact stiffness and macroscopic interference is established, and the results indicate that contact stiffness varies with interference due to the micro-convexity mechanism under compressive deformation. Therefore, the effect of speed should be considered when selecting appropriate interference design parameters. This study provides theoretical evidence to support the selection of optimal interference design parameters at multiple scales.
The Role Of Triamcinolone In Seroma Prevention In Extended Latissimus Dorsi Flap In Breast Reconstruction
Authors: Alajy Yacoub , Ammar Ali , Al-Aissami Maen 
Published: July 2023

Abstract
Background: Seroma remains a common complication of surgeries involving the extended latissimus dorsi flap (ELDF) for breast reconstruction. However, there are several methods that have been used to treat seroma. This study aims to evaluate the efficacy of topical administration of triamcinolone acetonide in reducing seroma incidence in breast reconstruction surgeries.
Methods: Cross sectional study was conducted at Al-Mouwasat University Hospital in Damascus-Syria. Between 2022-2023 including patients who came to the breast unit clinic seeking for breast reconstruction. 20 patients were injected with triamcinolone acetonide 80 mg on the fifth and seventh day of the surgery through the drain tube in the donor site. And the drain was removed directly on the seventh day of surgery. Follow up continued till 3 month post operation to report the seroma cases and other complications.
Results : Mean age was 47 years (range 30-60), mean body mass index (BMI) was 26 kg/m2, 11 flaps were for immediate reconstructions, and 9 cases were for delayed reconstruction. one case of seroma (n=1) 5% was reported , mastectomy flap necrosis was in 3 cases (15%), breast flap seroma was seen in just one case ( 5%) .
Conclusion: triamcinolone acetonide is considered easy and not expensive method for preventing seroma, therefore we recommend the topical usage of triamcinolone acetonide for prevention of seroma at the donor site of extended latissimus dorsi flap.
Trial registration: researchregistry9062
The circadian rhythms of mitochondrial function after transplantation of mesenchymal stem cells
Authors: Horiguchi Michiko , Mizukami Yoichi , Watanabe Kenji , Yoshihara Kenichi , Tsurudome Yuya , Ushijima Kentaro 
Published: July 2023

Abstract
Regenerative therapy involving stem cell transplantation has become an option for the radical treatment of diabetes mellitus. Disruption in the clock genes of stem cells affects the homeostasis of transplanted tissues. This is possibly the first study to examine the circadian rhythm of genes in transplanted adipose-derived mesenchymal stem cells derived from a patient with type 2 diabetes mellitus (T2DM-ADSC). The clock genes (PER2, CLOCK1, CRY1, and ARNTL[BMAL1]) exhibited similar daily fluctuations in phase and amplitude between a group transplanted with adipose-derived mesenchymal stem cells derived from a healthy individual (N-ADSC) and a group transplanted with T2DM-ADSC. The findings demonstrated that clock genes in stem cells are synchronized with those in living organisms. Moreover, mitochondrial genes and functions showed daily fluctuations in the N-ADSC group. However, such fluctuations were not noted in the T2DM-ADSC group. In the T2DM-ADSC group, daily fluctuations in MTATP8P1 and NDUFA7_2 genes disappeared. In the N-ADSC transplant, the results showed the circadian rhythm in the number of mitochondrial DNA copies, Mitophagy, the mitochondrial membrane potential and NF-kB signaling. In contrast, no daily fluctuations were observed in the T2DM-ADSC transplant. The circadian rhythms of mitochondrial function and NF-kB signaling revealed in this study may be a new marker for the efficiency of stem cell transplantation in patients with diabetes.
Association of schizophrenia, major depression, and bipolar disorder with sarcopenia-related traits: a bidirectional two-sample Mendelian randomization study
Authors: Zhu Dong , Yang Qifan , Wang Xinyu , Liu Yanwei , Liu Jing , Jiang Ye , Lin Liangxin , Lu SHiyuan , Chen Chunzheng , Wang Weixue 
Published: July 2023

Abstract
The rising incidence of schizophrenia, depression, bipolar disorder, and other mental illnesses have an association with sarcopenia (SP). Observational studies are susceptible to confounding factors. Mendelian randomization (MR) studies offer a way to mitigate the influence of such factors when assessing causality. The causal connection between schizophrenia, depression, bipolar disorder, and SP was evaluated using inverse-variance weighted (IVW) and other MR methods. Sensitivity analyses were also performed. We found schizophrenia exhibited a negative association with increased whole-body FFM (fat free mass) (odds ratio [OR] = 0.987, 95% CI: 0.979–0.996, P = 0.03), that was attributed to a reduction in FFM in both lower legs (OR = 0.990, 95% CI: 0.981–0.999, P = 0.037; OR = 0.984, 95% CI: 0.975–0.993, P = 0.000). Schizophrenia were negatively correlated in both upper limb, with OR = 0.987, 95% CI: 0.979–0.994, P = 0.001, OR = 0.986, 95% CI: 0.997–0.996, P = 0.004. Major depression and walking pace were negatively related (OR = 0.965, 95% CI: 0.935–0.996, P = 0.027). Bipolar disorder was associated with decreased left leg FFM (OR = 0.979, 95% CI: 0.960–0.999, P = 0.036). Both upper limbs showed a reduction in FFM, with the left and right limbs having an OR = 0.973, 95% CI: 0.953–0.993, P = 0.008 and OR = 0.973, 95% CI: 0.951–0.994, P = 0.014, respectively. Additionally, bipolar disorder was associated with increased walking pace (OR = 1.021, 95% CI: 1.005–1.038, P = 0.012).A potential causal relationship existed among SP-related traits, schizophrenia, and major depression, in addition to bipolar disorder. In conclusion, significant causal relationships exist between schizophrenia, major depression, bipolar disorder, and SP. SP worsens with the increasing severity of mental illness. SP demonstrated a potential causal relationship with schizophrenia and major depression, apart from bipolar disorder.
Effect of Wearing Peripheral Focus-out Glasses on Emmetropization in Chinese Children Aged 6-8 Years: Study Protocol For a 2-year, Randomized, Controlled Intervention Trial.
Authors: shen li , he wennan , yang weiming , yan weili , yang Chenhao 
Published: July 2023

Abstract

BackgroundMyopia is one of the most common eye diseases causing visual impairment and blindness, and the high prevalance in adolescents remains a major public health concern. Based on clinical studies using optical defocus to regulate ocular growth and refractive changes through visual feedback, we hypothesize that early wearing of peripheral myopic defocusing spectacles in children at high risk of myopia may slow the process of emmetropization and even prevent the onset of myopia by inducing more peripheral myopic defocus. The aim of this study is to investigate whether the wearing of peripheral focus-out glasses can be effective in delaying emmetropization in non-myopic children aged 6- 8 years.MethodsThe study is a 2-year, randomized, controlled trial. A total of 160 subjects will be randomized to the experimental or the control group. The experimental group will be fitted with Direct Emmetropia with Focus-out Glasses (DEFOG) to guide the emmetropization process. The control group will not receive any treatment and will serve as a blank control group. The primary aim is to determine whether non-myopic children wearing DEFOG lenses are superior to those who do not receive any intervention on progression of cycloplegic objective refraction over 2 years.DiscussionThis is the first randomized controlled trial aiming at myopic prevention by non-invasive intervention in non-myopic children. This study aims to initially investigate whether wearing peripheral focus-out glasses can effectively delay the process of emmetropization in children aged 6-8 year at high risk of myopia, which might give potential clues for further exploration on early prevention of myopia.Trial registrationNCT05689567 (https://clinicaltrials.gov/ct2/manage-recs/register, registered on 10 January 2023).
An Intelligent and Prognostic machine learning model for Glioblastoma Multiforme
Authors: Cheng Wen-Yu , Yang Chih-Chan , Kao Ju-­Hsuan , Shen Chiung-Chyi , Yang Yi-Chin , Tsai Meng-Hsiun 
Published: July 2023

Abstract
Glioblastoma multiforme (GBM) is a rapidly invasive brain tumor with a high mortality rate. It is accompanied by peripheral edema. Physicians use magnetic resonance imaging (MRI) to diagnose each patient’s condition in clinical practice. The current use of machine learning to classify brain tumors has an accuracy of about 90% in most studies. Therefore, this study aimed to improve its prediction accuracy using machine learning models to predict GBM patient survival or non-survival. The study used MRI T1-related and T2-related sequences to obtain GBM tumor and edema area attributes. It then divided them into four datasets: maximum tumor area, maximum edema area, total tumor volume, and total edema volume. These four datasets were used as inputs for classification models based on support vector machines, decision tree algorithms, random forest algorithms, and multilayer perceptron (MLP) to predict patient survival. A confusion matrix was used to evaluate each model and determine the most suitable models for each dataset based on their accuracy. MLP was the most appropriate for predicting the overall edema volume dataset, with the highest accuracy in predicting GBM patient survival or non-survival at 96.97%. Hopefully, this study can assist physicians in assessing and diagnosing GBM patients’ survival status in the future.
A novel mutation in the ABCD1 gene of a patient with X-linked adrenoleukodystrophy presenting with central precocious puberty: a case report
Authors: Zhu Ting Ting , Wu Jin , Sun Xiaomei 
Published: July 2023

Abstract

X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by the variations in the ATP-binding cassette sub-family D member 1 (ABCD1) gene located on the X-chromosome, leading to an accumulation of very long chain fatty acids (VLCFAs), which impair many tissues, including the cerebral white matter, the spinal cord, and the adrenal cortex. However, no study has reported central precocious puberty (CPP ) in individuals with X-ALD. A 6-year-old proband presented with pigmentation of the skin and mucosa, elevated levels of plasma adrenocorticotropic hormone and VLCFAs, and no neurological dysfunctions. He had rapid growth in height velocity, testicular size of 5–6 mL, and penile length of 6 cm. A novel variant, c.1826A > G (p.Glu609Gly), was identified in exon 8 of the ABCD1 gene.
Understanding the performance of global precipitation products for hydrological modeling in the data-scarce morphologically complex central Himalayan region
Authors: Sandilya Sneha , Singh Sunayana , Kumar Sonu 
Published: July 2023

Abstract
Developing a hydrological model is challenging in ungauged river basins. Hydrological modeling requires historical precipitation estimates. Global precipitation products (GPPs) have equipped hydrologists with a significant resource for hydrological applications such as flood modeling and forecasting. This study compares the quality and hydrological utility of four different GPPs in the Gandak river basin (Nepal and India), a representative of the morphologically complex Himalayan region. The study reveals that among the four GPPs, the SM2RAIN had the least average Root Mean Squared Error (RMSE) of 5.83 mm/day, and TRMM 3B42RT had the highest RMSE of 11 mm/day. When it comes to R-squared, SM2RAIN had the highest value (0.37), and TRMM 3B42 showed the lowest at 0.07. Similarly, Bias for SM2RAIN showed the most negligible average bias, which was − 5.34%, and TRMM 3B42 indicated the highest bias of 28.71%. POD for SM2RAIN was the highest at 0.83 and the lowest for TRMM 3B42RT (0.67). Similarly, when a hydrological model using MIKE 11 NAM model was developed and calibrated with observed rainfall data, TRMM 3B42 (daily), TRMM 3B42RT, APHRODITE, and SM2RAIN, the NSE were calculated to be 0.74, 0.81, -0.25 and 0.55 respectively for the calibration period and 0.67, 0.16, 0.4 and 0.50 respectively for the validation period. The TRMM 3B42RT data sets were not found to be suitable for hydrological modeling in the Gandak river basin as mostly the NSE value was found to be negative. The study reveals that the best-suited product among the four GPPs for hydrological simulations in the central Himalayan region is SM2RAIN, followed by the TRMM 3B42.
Experimental pathogenesis of aquatic bird bornavirus 1 in Pekin ducks
Authors: Ampuero Fernanda , Leacy Alexander , Pham Phuc H. , Che Sunoh , Jardine Claire , Nagy Eva , Delnatte Pauline , Lillie Brandon N. , Susta Leonardo 
Published: July 2023

Abstract

Aquatic bird bornavirus 1 (ABBV-1), a member of the Bornaviridae family, is a neurotropic virus that causes persistent infection in the nervous system of wild waterfowl. The goal of this study was to evaluate whether Pekin ducks, the most common waterfowl raised worldwide, are susceptible to ABBV-1 infection and associated disease. Two-day-old Pekin ducks (n, 121) were inoculated with ABBV-1 through the intracranial (IC), intramuscular (IM), or choanal (CH) routes. At 1, 12, and 21 weeks postinfection (wpi), 7–14 birds were euthanized to assess virus distribution and lesions. Infection rates in the IC and IM groups were over 70%, while only 4 ducks in the CH group became infected. Neurological signs were observed in 8 ducks only, while over 25% of IC and IM birds had encephalitis and/or myelitis. Seroconversion was highest in the IC and IM groups, and mucosal ABBV-1 RNA shedding was most frequent in the IC group (53%). None of the fertile eggs laid during the experiment tested positive for ABBV-1 RNA. This study shows that Pekin ducks are permissive to ABBV-1 infection and partly susceptible to associated disease. While mucosal shedding may be an important route of transmission, congenital infection appears unlikely.
A hot-spot analysis of forest roads based on soil erosion and sediment in Zagros forest lands, Iran
Authors: Yousefi Saleh , Emami Sayed Naeim , Nekoeimehr Mohammad , Rahmati Omid , Imaizumi Fumitoshi , Gomez Christopher 
Published: July 2023

Abstract
Forest roads have been recognized as one of the significant contributors to soil erosion processes in forested areas. The construction and maintenance of forest roads can cause severe environmental impacts, including soil erosion, sedimentation, and degradation of aquatic ecosystems. In summary, this study contributes to our understanding of the impacts of forest road networks on soil erosion and sedimentation in the context of Zagros forest land, Iran. This study aims to assess soil erosion and sedimentation on forest roads in four case studies in Zagros forest lands, Iran. The study collected data using field surveys and SEDMODL equations to determine input factors and sedimentation and erosion rates. The study found that road erosion is strongly correlated with geological factor, road width, and precipitation factors. The height changes of 144 benchmarks were recorded during one study year (2021–2022) in four study roads, and the measurement results of erosion benchmarks indicated an average soil erosion of 3, 2.6, 4.7, and 3.5 mm per year around Bidleh, Kohian, Nazi, and Tabrak roads, respectively. The study measured soil erosion and sedimentation at three distances (5, 15, and 25 meters) from the road and found a significant difference in the height changes of the benchmarks at varying distances from the study roads. Hot-spot analysis was conducted using GIS 10.8, and the results indicated that a significant portion of the studied forest roads had very high erosion production and hot-spots. The results of Hot-spot analysis indicated that 30.8%, 22.6%, 39.8%, and 14.5% of the study forest roads in Nazi, Tabrak, Bidleh, and Kohian roads, respectively, are identified as areas with very high erosion production and hot-spots. These results highlight the need for effective management strategies to minimize the impact of erosion on road infrastructure and the surrounding environment. Overall, this study provides important insights into soil erosion and sedimentation on forest roads, and the findings presented here can be used to inform future road construction and maintenance.
Domino, one-pot, three-component synthesis, anti-bacterial and molecular modelling studies of novel benzimidazole based isoindoline-1,3-dione and benzo[4,5]imidazo[2,1-b]thiazol hybrids
Authors: Chedupaka Raju , Perugu Shyam , Mamidala Srikanth , Venkatesham Papisetti , Penta Santhosh , Vedula Rajeswar Rao 
Published: July 2023

Abstract
A series of metal-free, thioalkylated benzimidazole-based isoindoline-1,3-dione (4a-w) and N-fused 4,5-benzo[4,5]imidaz[2,1-b]thiazole (5a-h) derivatives were synthesized via a novel, one-pot three-component approach. All the synthesized scaffolds were well characterized by analytical and spectroscopic techniques. The usefulness of this reaction is that it involves easy workup, shorter reaction time, broad substrate scope, and column-free purification of the products. Further, the synthesized scaffolds (4a-w) were evaluated for their in-vitro anti-microbial activity using two Gram-positive and two Gram-negative bacterial cell lines Escherichia coli, Salmonella typhi, Staphylococcus aureus and Micrococcus luteus by agar well diffusion method. Among tested compounds, compounds 4a, 4g, 4j, 4q, 4s, and 4t showed significant invitro antibacterial activity against Gram-positive and Gram-negative bacterial cell lines. Further, we have also insight of molecular docking studies, based on the docking results compounds 4s, 4j, 4a, 4q, 4t, and 4g have shown stable binding interaction with streptomycin drug with active site of the B-DNA (PDB ID: 1BNA). The antibacterial activity, and molecular docking studies of the title compounds were suggested that these are promising anti-bacterial active skeletons.
A Cross-sectional study of Challenges Faced by Under-Resourced Women with Substance Use Disorders during the COVID-19 Pandemic: Implications for Treatment and Care Delivery
Authors: Mejia M. Carmenza , Kowalchuk Alicia , Gonzalez Sandra , Webb Lisa , Nair Muktha , Scamp Nadine 
Published: July 2023

Abstract
Background: The COVID-19 pandemic has exacerbated existing disparities in access to mental health care and treatment for substance use disorders (SUD), particularly in under-resourced communities. This study aimed to understand the experiences of under-resourced women with substance use disorders during the COVID-19 pandemic, their knowledge and attitudes towards the pandemic, and its impact on their substance use and access to treatment.
Methods: This is a cross-sectional study of 66 under-resourced women receiving medically managed withdrawal treatment in a community residential SUD treatment center. Data were collected from November 2021 to August 2022 through a 75-item instrument covering topics related to COVID-19 exposure, pandemic impact on health, substance use, and access to treatment, COVID-19 vaccination status and attitudes, as well as knowledge and beliefs about the virus and pandemic risk mitigation measures. Descriptive analyses were conducted to summarize the data.
Results: Results revealed that participants faced numerous challenges during the pandemic. Many reported increased substance use, particularly alcohol, opioids, benzodiazepines, and nicotine. Mental health stability was also negatively impacted, with a majority reporting the exacerbation of existing mental health disorders and difficulties accessing mental health care. Job loss, housing instability, and financial strain were prevalent among the participants. Half of the respondents received at least one dose of a COVID-19 vaccine, while 27.3% did not receive the COVID-19 vaccine and were not considering it. Vaccine hesitancy was observed due to concerns about lack of knowledge and religious beliefs. The majority (62.1%) of participants felt that their greatest worry was about challenges to securing basic needs such as groceries or medication, and (64.6%) reported a desire to cope using alcohol or drugs.
Conclusions: These findings highlight the need for gender-responsive and culturally appropriate approaches to substance use disorders treatment. Additionally, efforts should focus on improving access to mental health care, reducing stigma, and providing resources and support to individuals with co-occurring mental health conditions during and after the pandemic. This study provides valuable insights to refine substance use care delivery and recovery services for under-resourced women, both in the early post-pandemic period and in preparation for future global crises.