bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability and existence of solutions to a class of Atangana-Baleanu-Caputo coupled fractional differential equations
Authors: Lin Xuefan , Hu {WeiMin , Su You-Hui , Yun Yongzhen 
Published: August 2023

Abstract
In this paper, we are concerned with the stability and existence of solutions to a class of Atangana-Baleanu-Caputo coupled fractional differential equations. The existence and uniqueness of the solution of the fractional system are obtained through Schaefer and Banach fixed point theorems, and sufficient conditions for the existence and uniqueness of the solutions are also developed. Subsequently, the Hyers-Ulam stability and generalized Hyers-Ulam stability of the solution are considered. In particular, two examples are given to illustrate the main results. The interesting aspect of this paper is that it performs numerical simulations using the monotone iterative method to verify the applicability of the system.
Acquired Von Willebrand Syndrome in a patient with Monoclonal Gammopathy of Unknown Significance: a case report
Authors: Gupta Garima , Veedu Janeesh , Chahine Zena , Iragavarapu Chaitanya 
Published: August 2023

AbstractBackground Monoclonal gammopathy of uncertain significance (MGUS) associated acquired von Willebrand syndrome (AvWS) is a rare life-threatening bleeding disorder driven by immunologic clearance of circulating von Willebrand factor (vWF). Treatments including factor replacement and intravenous immunoglobulin (IVIG) provide short-term bleeding control. Achieving a sustained response is frequently challenging and there remains lack of data regarding long-term management of MGUS-associated AvWS, specifically regarding plasma cell depleting agents. Case presentation: A 74-year-old female was diagnosed with AvWS while undergoing pre-operative workup for a knee replacement surgery. Peri-operative bleeding was successfully controlled with vWF/FVIII complex along with intravenous immunoglobulin (IVIG). However, she subsequently developed recurrent episodes of gastrointestinal bleeding without an identifiable source on upper endoscopy and colonoscopy. vWF/FVIII complex and IVIG only provided short-term bleeding control. Patient was then administered rituximab however, developed a severe infusion reaction and was not re-challenged. Incidentally, a circulating IgG kappa monoclonal paraprotein was noted, dating back to testing during initial diagnosis. Therefore, suspicion for MGUS-associated AvWS was raised and clonal directed treatment with bortezomib was initiated. Post 3 cycles of bortezomib, the monoclonal paraprotein became undetectable and there was normalization of vWF:Ag, vWF:RCo and factor VIII activity without recurrence of bleeding for over 18 months. Conclusions Clonal directed therapy with bortezomib resulted in eradication of the monoclonal paraprotein causing suppression of the underlying immunological process which led to a durable remission in our patient with MGUS-associated AvWS. Bortezomib may be considered as a viable treatment option to achieve long-lasting bleeding control in patients with MGUS-associated AvWS.
The Creative AI-Land: Exploring new forms of creativity
Authors: Vinchon Florent , Gironnay Valentin , Lubart Todd 
Published: August 2023

Abstract
This study examines generative artificial intelligences (GAI), as popularised by ChatGPT, in standardised creativity tests, uncovering what we called the “creative AI-Land”. As the study of creativity was metaphorically seen as a trip across the seven seas (C’s) by Lubart, we conceptualise AI creativity as uncharted territory in the creativity field. Benchmaking GAI against human performance, results show that ChatGPT demonstrates remarkable fluency in content generation, though the creative output is average. The random nature of AI creativity and the dependency on the richness of the training database require a reassessment of traditional creativity metrics especially for AI. Our findings highlight the integral role humans play in guiding AI to foster genuine originality, suggesting the need for future research in human-AI co-creation and the development of robust AI creativity measurement mechanisms.
A scenario-based analysis of selected best management practices for reduced sediment and nutrient yield in the watershed located in the Shivalik hills, India
Authors: Walia Sushma , Babbar Richa , Singh Sarbjit 
Published: August 2023

Abstract

In this study, an attempt has been made to evaluate the best management practices (BMPs) in a poorly degraded and economically fragile watershed area in Shivalik hills, Northern India. A scenario-based approach was followed to evaluate the existing BMPs and a few hypothetically implemented BMPs based on SWAT modeling. A regionalization approach was adopted for calibrating the SWAT model for ungauged micro-watersheds within the study area. After successful calibration, soil and water assessment tool (SWAT) model was simulated for several BMPs that are in practice such as Check dams, vegetation and fencing so as to learn about their effectiveness in controlling sediment and nutrient yield. Other hypothetically installed BMPs, such as contouring, terracing, grassed waterways and filter strips were also evaluated in untreated micro and sub-watersheds. The cost–benefit analysis of these hypothetical BMPs revealed that the average reduction in nutrients was maximum for grassed waterways and minimum for terracing. Overall, the scenario-based analysis revealed that conservation practices, in the otherwise degraded watershed, can prove to be beneficial for sustainability of its natural resources.
O cuidado humano à saúde do idoso sob a ótica da Antropologia por Clifford Geertz
Authors: Biondo Chrisne Santana , Pedreira Rhaine Borges Santos , Santos Lucas dos , Sena Edite Lago da Silva , Carvalho Patrícia Anjos Lima de , Boery Rita Narriman Silva de Oliveira 
Published: August 2023

O envelhecimento é marcado por muitas alterações nas condições de vida e saúde, no entanto observa-se que a assistência em saúde, geralmente, não leva em consideração fatores socioculturais de cada indivíduo. Portanto, levar em conta esses fatores pode facilitar a adesão dos idosos ao tratamento em saúde e consequentemente atingir o cuidado integral em saúde, preservando os princípios bioéticos. Objetivo: Refletir sobre o entrelaçamento de aspectos socioculturais e bioéticos no cuidado integral ao idoso, sob as lentes da Antropologia Interpretativa da Cultura em Geertz. Método: Trata-se de uma reflexão teórica seguindo o conceito de cultura proposto por Clifford Geertz. Reflexão: a cultura para Geertz é entendida como uma teia de significados socialmente aceitos, por meio do qual os indivíduos reagem às situações vivenciadas. A partir desse pressuposto, podemos propor ações de cuidado em saúde com enfoque na realidade dos idosos, considerando-os como atores do processo de saúde e doença, impedindo a perpetuação do ageísmo no cuidado em Saúde. Outrossim, a inserção dos idosos no cuidado, o respeito e associação da sua cultura e crenças no tratamento, propostos pelos profissionais da Saúde, respeitará os princípios bioéticos da não-maleficência, beneficência, justiça e autonomia, efetivando um cuidado integral e ético em Saúde. Considerações finais: A partir dessa reflexão, observou-se que condutas ageístas permanecem ocorrendo e que os profissionais não estão preparados para a inserção dos aspectos culturais no contexto da Saúde. Assim, é imperioso mudanças na formação do profissional em Saúde sensibilizando-os para a inserção desses aspectos em sua prática profissional.
Palavras-chave: Antropologia da Saúde; Saúde do Idoso; Bioética.
Espiritualidade na Maternidade Atípica: Uma Reflexão com Base no Referencial Teórico de Victor Frankl
Authors: Moura Mônica , Handan de Deus Vilza Aparecida , Silva Rose Mary Costa Rosa Andrade , Pereira Eliane Ramos , Bessa de Paulo Verônica , Silva Rita de Cássia Ferreira da 
Published: August 2023

Resumo
A maternidade atípica desafia as convenções sociais e traz consigo um conjunto único de desafios e experiências para as mulheres que a vivenciam. Neste artigo de reflexão, exploramos a importância da espiritualidade como um recurso fundamental para enfrentar esses desafios e encontrar significado na jornada da maternidade atípica. Utilizando o referencial teórico do renomado psicólogo Viktor Frankl, que enfatiza a busca por sentido e propósito na vida, examinamos como a espiritualidade pode fornecer um apoio emocional e psicológico essencial para as mães que enfrentam circunstâncias únicas e muitas vezes difíceis. Além disso, discutimos a relevância da espiritualidade na construção de resiliência, na promoção do bem-estar emocional e no fortalecimento dos laços familiares durante essa jornada desafiadora.
Palavras-chave: crianças com deficiência; espiritualidade; relação mãe/cuidador familiar.
Probability of the 10-year Risk of Hip and Major Osteoporotic Fracture in
Non-radiographic Axial Spondyloarthritis
Authors: Ferjani Hanene Lassoued , Boudriga Ons , Nessib Dorra Ben , Kaffel Dhia , Maatallah Kaouther , Hamdi Wafa 
Published: August 2023

Background:
Fracture risk in non-radiographic spondyloarthritis is underestimated. A reliable tool such as the Fracture Risk Assessment tool (FRAX) may assess this risk probability. This study aimed to assess the fracture risk by the FRAX score in patients with nr-axSpA and to de-termine factors associated with high fracture risk.

Methods:
We conducted a retrospective study of nr-axSpA patients meeting the Assessment of SpondyloArthritis International Society (ASAS) classification criteria for spondyloarthritis. All pa-tients had Bone Mineral Density (BMD) by dual-energy X-ray absorptiometry (DEXA). The 10-year probability of major osteoporotic fracture (MOF) and hip fracture (HF) was calculated using the Fracture Risk Assessment Tool (FRAX).

Results:
Among 40 patients with nr-axSpA, 27 were women (67.5%). Their mean age was 43.7 ± 12.1 years. The mean disease duration was 3.15 ± 2.7 years. Eighteen patients (45%) had osteo-penia, and 12 patients (30%) had osteoporosis. The median HF FRAX was 0% [0-1.2]. The median MOF FRAX was 0.5% [0.3-1.8]. MOF FRAX was positively correlated with age (p = 0.002), dis-ease onset age (p = 0.006), disease duration (p = 0.024), and the modified Stoke Ankylosing Spon-dylitis Spine Score (mSASSS) (p < 0.0001), and negatively correlated with daily calcium intake (p < 0.0001). HF FRAX was positively correlated with mSASSS (p < 0.0001) and negatively correlat-ed with daily calcium intake (p = 0.005).

Conclusion:
Our study confirmed the frequency of bone loss during nr-axSpA and showed that os-teoporotic risk fracture was related not only to traditional risk factors for osteoporosis but also to disease-related factors.
Preclinical Appraisal of the Aphrodisiac Effects of Emblica officinalis
Seed Extract on Stress-induced Sexual Behavior in Albino Rats
Authors: Kadiri Sunil Kumar , Khobragade Deepak S. , Roy Samaresh Pal 
Published: August 2023

Background:
The king of herbs, Emblica officinalis, is one of the most important herbs in
Ayurveda. It contains significant amounts of Vitamin C and has been reported to have antioxidant, anticancer,
antiretroviral, antidepressant, antiulcerogenic, wound healing, and many other medicinal
properties.

Objective:
The current study is designed to investigate the aphrodisiac effects of E. officinalis seed extract
on albino Wistar rats as well as its effects on stress-related sexual behaviour.

Materials and Methods:
The aphrodisiac effect of E. officinalis was evaluated by mating the pretreated
male rats with female rats. For 30 days, test group rats (n=6) were given methanolic extracts (95%)
from E. officinalis seeds (500 and 1000 mg/kg). Control rats received saline. Standard group rats received
testosterone (0.5 mg/ kg, i.m). The sexual behavior study tracked Mount Latency (ML), Intromission
Latency (IL), Mounting Frequency (MF), Intromission Frequency (IF), sniffing, and licking
on days 0 through 30. After 30 days, rats were sacrificed, and the anabolic effect was assessed using
body weight, reproductive organ weight, sperm concentration, and histopathology of the testes. The
stress was induced by immobilization stress in the stress-affected alteration in the sexual behavior
model, and the above procedure was repeated for evaluation.

Results:
The 95% methanolic extract (1000 mg/kg) of E. officinalis significantly reduced ML and IL
while significantly increasing MF, IF, sniffing, licking, body weight, reproductive organ weight, and
sperm concentration. Methanolic extract of E. officinalis increased sexual activities in the stress-free
group and restored the stress-affected group's altered sexual behaviour.

Conclusion:
The current study's findings indicate that 95% methanolic extract of E. officinalis has
dose-dependent aphrodisiac activity and restores sexual behavior in a stress-induced group.
Preparation of Ketoconazole-loaded Nanoemulsions for Ophthalmic
Delivery: Characterization and In-vitro Antifungal Activity Evaluation
Authors: Mahboobian Mohammad Mehdi , Azadi Negin , Pourmoslemi Shabnam 
Published: August 2023

Background:
Nanoemulsions (N.E.s) capable of ocular bioavailability elevation can be
used for poor water-soluble drugs such as ketoconazole (K.Z.). The current investigation was designed
for the purpose of overcoming this issue by developing K.Z. containing N.E.s for ophthalmic drug
delivery with appropriate therapeutic efficiency.

Methods:
The preparation of ketoconazole N.E.s was performed by the low-energy technique.
According to the phase diagram, three stable formulations were selected for more physicochemical
analyses, including particle size, polydispersity index, pH, refractive index and viscosity. Finally, drug
release patterns and in-vitro antifungal activity were assessed for the final selected formulation.

Results:
The developed N.E. formulations with droplet sizes less than 20 nm showed appropriate
physicochemical characteristics for ocular delivery. The selected formulation released 100% of the
encapsulated drug during 24 h. Moreover, antifungal assessments showed that prepared N.E. had
acceptable in-vitro antifungal activity.

Conclusions:
Based on our findings, it can be concluded that N.E.s could be applied as effective
carriers for the ophthalmic delivery of ketoconazole.
Bacoside A: A Promising Medication for Treatment of Various Disorders
Authors: Bansal Keshav , Singh Vanshita , Bajpai Meenakshi 
Published: August 2023

Abstract:
Bacoside A is a triterpenoid saponin and nootropic herb that can be extracted from Bacopa monnieri Linn., Scrophulariaceae. It is a glabrous and succulent herb used traditionally for centuries in treating various illnesses, mainly as a cardiotonic and nerve tonic, and has been considered an eminent Ayurvedic medicine. Various studies reported that the herb consists of a wide range of potentially bioactive, phytochemical constituents with synergistic effects. Bacoside A is a major constituent of B. monnieri, with diverse biological functions and significant therapeutic potential, as given by various researchers and preclinical studies. It possesses various biological activities such as hepatoprotective, anti-osteoporotic, anti-ulcerogenic, anti-inflammatory, anti-tumor, wound healing, and neuroprotective effects. This review compiled the preclinical evidence-based studies and present knowledge of bacoside A's potential benefits and fruitful impact on human health, and we provided a comprehensive perspective of bacoside A in various disease treatments.
The “Loci” of Misinformation and Its Correction in Peer- and Expert-Led Online Communities for Mental Health: Content Analysis
Authors: Bizzotto Nicole , Schulz Peter Johannes , de Bruijn Gert-Jan 
Published: August 2023

Background
Mental health problems are recognized as a pressing public health issue, and an increasing number of individuals are turning to online communities for mental health to search for information and support. Although these virtual platforms have the potential to provide emotional support and access to anecdotal experiences, they can also present users with large amounts of potentially inaccurate information. Despite the importance of this issue, limited research has been conducted, especially on the differences that might emerge due to the type of content moderation of online communities: peer-led or expert-led.

Objective
We aim to fill this gap by examining the prevalence, the communicative context, and the persistence of mental health misinformation on Facebook online communities for mental health, with a focus on understanding the mechanisms that enable effective correction of inaccurate information and differences between expert-led and peer-led groups.

Methods
We conducted a content analysis of 1534 statements (from 144 threads) in 2 Italian-speaking Facebook groups.

Results
The study found that an alarming number of comments (26.1%) contained medically inaccurate information. Furthermore, nearly 60% of the threads presented at least one misinformation statement without any correction attempt. Moderators were more likely to correct misinformation than members; however, they were not immune to posting content containing misinformation, which was an unexpected finding. Discussions about aspects of treatment (including side effects or treatment interruption) significantly increased the probability of encountering misinformation. Additionally, the study found that misinformation produced in the comments of a thread, rather than as the first post, had a lower probability of being corrected, particularly in peer-led communities.

Conclusions
The high prevalence of misinformation in online communities, particularly when left uncorrected, underscores the importance of conducting additional research to identify effective mechanisms to prevent its spread. This is especially important given the study’s finding that misinformation tends to be more prevalent around specific “loci” of discussion that, once identified, can serve as a starting point to develop strategies for preventing and correcting misinformation within them.
E-Modul Literasi Berbasis Cerita Rakyat pada Pembelajaran Bahasa Indonesia Siswa Kelas VI
Authors: Wijayanti Ni Kadek Arthiwi , Wulandari I Gusti Agung Ayu , Wiarta I Wayan 
Published: August 2023

Kurangnya aktivitas membaca oleh para murid saat situasi pandemi covid 19 dan kurangnya pemanfaatan media pembelajaran dalam kegiatan pembelajaran pada muatan bahasa Indonesia kelas VI. Tujuan dari penelitian ini yakni untuk mengetahui hasil validitas media yang dikembangkan dari para pakar dan uji coba pada siswa. Penelitian ini tergolong kedalam penelitian pengembangan, yang dikembangkan dengan menggunakan model ADDIE. Subjek yang terlibat dalam penelitian ini meliputi 1 ahli isi mata pelajaran, 1 pakar desain pembelajaran dan 1 pakar media pembelajaran. Sedangkan subjek uji coba produk meliputi uji coba secara individual dengan 3 orang murid dan dan uji coba secara kelompok dengan 9 orang siswa kelas VI. Pengumpulan data dalam penelitian dilakukan menggunakan metode angket, observasi, dan wawancara dengan instrument penelitian berupa kuesioner validitas media pembelajaran. Data yang diperoleh dalam penelitian kemudian dianalisis dengan menggunakan teknik analisis deskriptif kuantitatif dan deskriptif kualitatif. Hasil penelitian menunjukkan bahwa pada uji validasi produk berdasarkan hasil uji ahli isi mata dengan pesentase 96,66% kategori sangat baik, uji ahli desian pembelajaran dengan pesentase 92,5% kategori sangat baik, uji ahli media pembelajaran dengan persentase 100% kriteria sangat baik, uji coba perorangan dengan hasil 90,14% kriteria sangat baik dan uji coba kelompok kecil dengan 89,64 % atau kriteria baik. Mengacu pada hasil validasi oleh ahli dan uji coba produk maka dapat disimpulkan bahwa aplikasi e-modul literasi berbasis cerita rakyat dianggap layak untuk menjadi media pembelajaran untuk memahami materi teks fiksi pada muatan Bahasa Indonesia pelajar kelas VI SD dan dapat digunakan sebagai media untuk fasilitas membaca.
Model Flipped Classroom Berbantuan SOFLEN (Song for Learning) Meningkatkan Hasil Belajar Ilmu Pengetahuan Sosial
Authors: Amalia Ilmi , Setiawan Deni 
Published: August 2023

Penggunaan model dan media pembelajaran yang kurang tepat menyebabkan peserta didik cenderung pasif dalam proses pembelajaran, sehingga membuat rendahnya hasil belajar peserta didik. Tujuan dari penelitian ini adalah untuk menguji keefektifan model pembelajaran Flipped Classroom dengan bantuan media SOFLEN (Song for Learning) terhadap hasil belajar dalam muatan pelajaran IPS. Penelitian ini menggunakan pendekatan kuantitatif eksperimen dengan metode Pretest-Posttest Control Group Design. Teknik sampling yang digunakan adalah sampling jenuh dengan melibatkan 54 peserta didik, terdiri dari 27 peserta didik di kelas VB (kelompok eksperimen) dan 27 peserta didik di kelas VA (kelompok kontrol). Pengumpulan data dilakukan memalui teknik tes dan observasi. Analisis data meliputi uji prasyarat yang terdiri dari uji normalitas dan homogenitas serta uji hipotesis yang dilakukan melalui uji independent sample T-test. Hasil penelitian menunjukkan bahwa data memiliki distribusi normal dan homogen. Ada perbedaan yang signifikan antara kelas eksperimen dan kelas kontrol. Oleh karena itu, Ho ditolak dan Ha diterima. Nilai rata-rata posttest kelas eksperimen adalah 88,89, sedangkan nilai rata-rata kelas kontrol adalah 57,78. Disimpulkan bahwa model pembelajaran Flipped Classroom berbantuan media SOFLEN (Song for Learning) lebih efektif dibandingkan dengan model pembelajaran konvensional dalam meningkatkan hasil belajar IPS peserta didik.
Saúde do Trabalhador:
Authors: Silva Bruna Gabriela Mechi da , Nascimento Camila Lima , Nakamura Helenice Yemi 
Published: August 2023

Introdução: A fonoaudiologia teve inserção na Saúde do trabalhador principalmente por práticas de cuidados relacionados a audição e voz. Para a oferta de um cuidado mais aderente às necessidades dos trabalhadores, é necessário que as práticas fonoaudiológicas se ampliem nesse campo, propondo ações de promoção em saúde e cuidados em distúrbios da comunicação relacionados ao trabalho, visando a atenção integral à saúde dos trabalhadores e, assim, desapegando-se das ações essencialmente assistenciais e reabilitadoras. Objetivo: O presente estudo se propõe a compreender a formação do Fonoaudiólogo em Saúde do Trabalhador. Método: Trata-se de um estudo quantitativo, aplicou-se questionário eletrônico aos Fonoaudiólogos que atuam em Centros de Referência em Saúde do Trabalhador (CERESTs) buscando descrever o perfil desses profissionais, sua relação com o trabalho e as práticas realizadas. Resultados: Foram alcançados 33 fonoaudiólogos que atuam em Centros de Referência em Saúde do Trabalhador (CERESTs) do país em 14 estados brasileiros. O estudo verificou um grupo de profissionais majoritariamente feminino, porém heterogêneo quanto ao ano de formação, faixa etária, ano de entrada no CEREST e tempo de serviço. Verificou-se que as cargas horárias semanais variam de seis a 44 horas e, ainda, que as fonoaudiólogas realizam além das ações de núcleo específicas, atividades coletivas internas, externas, intersetoriais e ações de vigilância. Conclusão: Foi possível caracterizar o perfil das fonoaudiólogas que atuam nos CERESTs, além de levantar as ações e atividades realizadas, contribuindo para o entendimento do atual estado da Saúde do Trabalhador na Fonoaudiologia e para a proposição de ampliação da atuação na área.