bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing Regression Testing with AHP-TOPSIS Metric System for Effective Technical Debt Evaluation
Authors: Zarrad Anis , Bahsoon Rami , Manimaran Priya 
Published: July 2023

Abstract

Regression testing is essential to ensure that the actual software product confirms the expected requirements following modification. However, it can be costly and time-consuming. To address this issue, various approaches have been proposed for selecting test cases that provide adequate coverage of the modified software. Nonetheless, problems related to omitting and/or rerunning unnecessary test cases continue to pose challenges, particularly with regard to technical debt (TD) resulting from code coverage shortcomings and/or overtesting. In the case of testing-related shortcomings, incurring TD may result in cost and time savings in the short run, but it can lead to future maintenance and testing expenses. Most prior studies have treated test case selection as a single- or two-objective optimization problem. This study introduces a multi-objective decision-making (MODM) approach to quantify and evaluate TD in regression testing. The proposed approach combines the analytic-hierarchy-process (AHP) method and the technique of order preference by similarity to an ideal solution (TOPSIS) to select the most ideal test cases in terms of objective values defined by the test cost, code coverage, and test risk. This approach effectively manages the software regression testing problems. The AHP method was used to eliminate subjective bias when optimizing objective weights, while the TOPSIS method was employed to evaluate and select test-case alternatives based on TD. The effectiveness of this approach was compared to that of a specific multi-objective optimization method and a standard coverage methodology. Unlike other approaches, our proposed approach always accepts solutions based on balanced decisions by considering modifications and using risk analysis and testing costs against potential technical debt. The results demonstrate that our proposed approach reduces both TD and regression testing efforts.
2022 MSC: 00-01, 99-00
Selenium-Integrated Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for NIR-II Imaging-Guided Cancer Phototheranostics In Vivo
Authors: Yang Lele , Gao Yijian , Wei Jinchao , Cheng Zehua , Wu Sijia , Zou Liang , Li Shengliang , Li Peng 
Published: July 2023

Abstract
Second near-infrared (NIR-II) fluorescence imaging in the range of 1000–1700 nm has great prospects for in vivo imaging and theranostics monitoring. At present, few NIR-II probes with theranostics properties have been developed, especially the high-performance organic theranostics material remains underexploited. Herein, we demonstrate a selenium-tailoring method to develop high-efficient NIR-II imaging-guided material for in vivo cancer phototheranostics. Via selenium (Se)-tailoring strategy, conjugated oligomer TPSe-based nanoparticles (NPs) achieve bright NIR-II emission up to 1400 nm and exhibit a relatively high photothermal conversion efficiency of 60% with good stability. Moreover, the TPSe NPs demonstrate their photothermal ablation of cancer cells in vitro and tumor in vivo with the guidance of NIR-II imaging. It is worth noting that the TPSe NPs have good biocompatibility without obvious side effects. Thus, this work provides new insight into the development of NIR-II theranostics agents.
Pediatric urogenital schistosomiasis diagnosed in France
Authors: percheron lucas , Leblanc Claire , Ulinski Tim , Fila Marc , Malvy Denis , Bacchetta Justine , Guigonis Vincent , Debuisson Cecile , Launay Elise , Martinez-Casado Edouard , Morand Aurelie , Decramer Stephane , Berry Antoine 
Published: July 2023

Abstract
Introduction:
Schistosomiasis affects approximately 230 million people worldwide. With the rise of international travel and immigration from endemic areas, there is an increase incidence of imported urinary schistosomiasis cases in France witch raise the risk of indigenous cases as observed in Corsica. European pediatricians are not used to this pathology. The objective of this study is to provide a better description of the clinical and paraclinical characteristics and the evolution of affected children.
Material and methods:
We contacted all French pediatric centers that may have treated children with urinary schistosomiasis, between 2013 and 2019, through the French pediatric nephrology society and the pediatric infectious pathology group. Age, sex, comorbidities, initial and follow-up clinical, biological and radiological characteristics were collected retrospectively.
Results:
A total of 122 patients from 10 different centers were included. The median age was 14 years and the sex ratio M/F was 4:1. Hematuria was present in 82% of the patients while urinary tract abnormality were found in 36% of them. 14 patients (11%) presented with complicated form of urinary schistosomiasis including 10 patients with renal failure. All patients received treatment with praziquantel, which was well tolerated and led to clinical resolution of the disease in 98% of cases.
Conclusion:
The diagnosis, management and follow-up of genital schistosomiasis must be improved, particularly by implementing systematic screening of patients returning from endemic areas, conducting renal ultrasounds and searching for nephrological complications such as renal failure and persistent proteinuria. A prospective study to evaluate long-term complications is essential.
A Network Analysis of Gaming Motivations and Internet Gaming Disorder Symptoms among Heterogeneous Low-Risk and High-Risk Adolescents
Authors: Chen Shiyun , Zhu Shimin 
Published: July 2023

Abstract
Background.
The increasing prevalence of internet gaming disorder (IGD) among adolescents has become a global concern, and gaming plays a large role in many adolescents’ lives. While prior research emphasised the significance of investigating IGD through an etiological lens, the interconnections between diverse gaming motivations and IGD symptoms in adolescents remain inadequately understood. This study explored the associations between distinct gaming motivations and IGD symptoms by conducting network analysis among heterogeneous low- and high-risk adolescents.
Methods.
Data from a two-year school-based survey was used (N = 2,148). Latent profile analysis (LPA) was conducted to identify adolescents with low- and high-risk IGD. A network analysis was conducted to examine and compare the associations between gaming motivations and IGD symptoms among low- and high-risk adolescents.
Results.
Three IGD profiles were identified in two time points, classifying adolescents with healthy transitions as low-risk and those with deteriorating transitions as high-risk. Three gaming motivations (i.e., ‘Daily entertainment’, ‘I am good at it’, and ‘Improvement of ability and mindset’) were identified as protective motivations. Two others, ‘Enjoy being in the gaming world’ and ‘Preoccupation’, were identified as bridge nodes in high-risk adolescents. Three core nodes (i.e., ‘Sense of victory’, ‘Enjoy being in the gaming world’, and ‘Sense of achievement’) were identified in both low-risk and high-risk groups.
Conclusion.
Findings suggest that not all gaming motivations contribute to the development of IGD in adolescents. High-risk adolescents showed unique bridge nodes between motivations and IGD symptoms. Future interventions should consider gaming motives to address IGD among adolescents.
Augmentation of nitrogen management reduce nitrogen stress and enhance productivity of super-seeder sown wheat under rice residue incorporation
Authors: Raising L Peace , Singh Virendra Pratap , Chandra Subhash , Shukla Anil , Pareek Navneet , Zhiipao R Rustum , Re Kadapa Sreenivas , Duo Hriipulou , Dorjee Lham , Karthik Rayapati , Singh V.K 
Published: July 2023

Abstract
The in-situ management of rice straw incorporation is now an essential practice in the rice-wheat cropping system with the growing adoption of super-seeder among farmers. However, the effect of nutrient immobilization due to incorporation of massive organic residues at the initial stage of the decomposition is a major constraint for better yield and productivity. This study investigates the effect of bio-decomposer, nitrogen (N) level, and N scheduling on N immobilization status, dry matter, N accumulation, and remobilization and productivity in super-seeder sown wheat for two consecutive years (2020-21 and 2021-22). The experiment was laid in split-plot design with two factors in the main plot viz., without (B0) and with (B1) application of bio-decomposer and nitrogen levels 150 (N1) and 180 (N2) kg ha− 1; and three N splits (%) in sub-plot viz., 50: 25:25 (S1), 40: 30: 30 (S2), and 30 :35:35 (S3) and replicated thrice. N content and uptake at pre- and post-anthesis were recorded significantly higher with N2 and S1 compared to N1 and S2 and S3 in both the years. Post-anthesis N accumulation (post-NA) and N remobilization (NR) with N2 was significantly higher to the tune of 22% and 17% than N1. Dry matter accumulation (DMA) at anthesis and harvest with N2 was significantly higher by 5.7%, while with S1 there is an improvement of 6.2% over S3. The grain yield with N2 and S1 significantly improved by 8.3% and 10.9% (two years mean) compared to N1 and S3, respectively. Soil urease activity was significantly enhanced with the application of microbial formulation (bio-decomposer), N2, and S1 in comparison to B0, N1 and S3 at 30 and 60 DAS (days after sowing). Hence, the present study revealed that the application of microbial-formulation and higher N level coupled with higher proportion of basal N could be propounded for sustainable production and higher productivity. Besides, use of bio-decomposer also improved soil health. The result presented here assumes great significance in proper utilization and conservation of rice residue under rice-wheat cropping system.
Bclaf1-induced HIF-1α accumulation under normoxia enhances PD-L1 treatment resistances via Bclaf1-CUL3 complex
Authors: Yao Bowen , Lu Ye , Li Yazhao , Bai Yixue , Wei Xinyu , Yang Yuanyuan , Yao Demao 
Published: July 2023

Abstract
Bcl-2-associated transcription factor-1 (Bclaf1), an apoptosis-regulating protein of paramount significance, orchestrates the progression of various malignancies. This inquiry reveals the heightened expression of Bclaf1 in hepatocellular carcinoma (HCC) patients, where its elevated levels are conspicuously linked to escalated tumor grades and diminished survival rates. Moreover, novel Bclaf1 exhibits a surge in expression within HCC patients who were not sensitive to the combined treatment of atezolizumab and bevacizumab in contrast to patients who chose such regiment and tumors got weak. Notably, the overexpression of Bclaf1 profoundly fosters HCC cell proliferation in vitro and in vivo, while the conditioned medium derived from these overexpressing cells strikingly enhances the tube-formation capacity of human umbilical vein endothelial cells (HUVECs). Furthermore, compelling evidence demonstrates that Bclaf1 attenuates the expression of prolyl hydroxylase domain protein 2 (PHD2) and governs the stability of hypoxia-inducible factor-1α (HIF-1α) under normoxic conditions, without exerting any influence on transcription, as determined by western blotting and RT-qPCR analyses. Subsequently, employing Co-Immunoprecipitation, we validate the reciprocal interaction between Bclaf1 and Cullin 3 (CUL3), whereby Bclaf1 actively up-regulates the ubiquitination and degradation of PHD2. Western Blot and RT-qPCR analyses suggest that programmed death ligand-1(PDL1) is one of the downstream responders to HIF-1α in HCC. In conclusion, this groundbreaking investigation unveils the pivotal role of Bclaf1 in promoting PDL1 transcription,and in promoting the accumulation of HIF-1α under normoxic conditions through its binding to CUL3, thereby facilitating the ubiquitination and degradation of PHD2.
Integrated analysis of tumor microenvironment features to establish a diagnostic model for papillary thyroid cancer by using bulk and single-cell RNA sequencing technology
Authors: Wang Yizeng , Song Wenbin , Li Yingxi , Liu Zhaoyi , Zhao Ke , Jia Lanning , Wang Xiaoning , Jiang Ruoyu , Tian Yao , He Xianghui 
Published: July 2023

Abstract
Purpose Characterizing tumor microenvironment by using single-cell RNA sequencing has been a promising strategy for cancer diagnosis and treatment. However, a few studies have focused on diagnosing papillary thyroid cancer (PTC) through this technology. Therefore, our study explored tumor microenvironment (TME) features and identified potential biomarkers to establish a diagnostic model for papillary thyroid cancer.Methods The cell types were identified using the markers from the CellMarker database and published research. The CellChat package was conducted to analyze the cell-cell interaction. The SCEVAN package was used to identify malignant thyroid cells. The SCP package was used to perform multiple single-cell downstream analyses, such as GSEA analysis, enrichment analysis, pseudotime trajectory analysis, and differential expression analysis. The diagnostic model of PTC was estimated using the calibration curves, receiver operating characteristic curves, and decision curve analysis. RT-qPCR was performed to validate the expression of candidate genes in human papillary thyroid samples.Results Eight cell types were identified in the scRNA-seq dataset by published cell markers. Extensive cell-cell interactions like FN1/ITGB1 existed in PTC tissues. We identified 26 critical genes related to PTC progression. Further, eight subgroups of PTC tumor cells were identified and exhibited high heterogenicity. The MDK/LRP1, MDK/ALK, GAS6/MERTK, and GAS6/AXL were identified as potential ligand-receptor pairs involved in the interactions between fibroblasts/endothelial cells and tumor cells. Eventually, the diagnostic model constructed by TRPC5, TENM1, NELL2, DMD, SLC35F3, and AUTS2 showed a good efficiency for distinguishing the PTC and normal tissues.Conclusions Our study comprehensively characterized the tumor microenvironment in papillary thyroid cancer. Through combined analysis with bulk RNA-seq, six potential diagnostic biomarkers were identified and validated. The diagnostic model we constructed was a promising tool for PTC diagnosis. Our findings provide new insights into the heterogenicity of thyroid cancer and the theoretical basis for diagnosing thyroid cancer.
PoS tag-based Attention for Feature Selection in Sentiment Analysis
Authors: Kanakkahewa K. H.S.L , Mohotti W. A. , Subhashini L. D.C.S. 
Published: July 2023

Abstract
The growth in the usage of the Internet and Web-based applications has led to an exponential increase in text data, including customer reviews, social media comments, and blogs. Sentiment analysis is an essential technique to analyze this data and determine the polarity of opinions. However, traditional sentiment analysis methods face challenges in feature selection and representation due to the unstructured nature of the text and associated noise. We propose a novel framework called PoPoSBert that uses BERT to capture syntax, semantic, and contextual features effectively. We leverage part-of-speech (PoS) tags which assign a unique identifier to every single token in a text corpus to indicate the part of speech, to capture polarity words that reveal the sentiment behind the text. We use the transformer architecture's attention mechanism to improve the weights for polarity words, resulting in high-quality feature selection for sentiment classification. We conducted an extensive experimental analysis to evaluate the suggested framework against the existing methods. The suggested framework is assessed using several standard evaluation measures such as accuracy, precision, recall, and F1-score against the traditional baseline methods such as TF-IDF and existing models like BERT, Word2Vec, and GloVe techniques. The findings indicate that the PoS tag-based attention concept improves the accuracy of sentiment classification, achieving superior performance over existing methods on several benchmark datasets. The suggested framework can be utilized in various applications, including market research, monitoring social media and analyzing customer feedback to make informed decisions.
Characterization and compositional identification of Stepwell (Baoli) lime plasters from 16 th Century Arab
Authors: Singh Sanjeev Kumar , Singh Manager Rajdeo 
Published: July 2023

Abstract

The present work deliberates on a 16th-century stepwell lime plaster sourced from Arab Ki Sarai, Humayun tomb complex, Delhi. The plaster samples were observed under an analytical microscope, and the thin section was examined through petrological analysis. The samples were also investigated using analytical techniques of XRF, FTIR, XRD, SEM-EDX, and thermal analysis. The brick-lime junction of the plaster studied using FTIR, XRD, and EDX analysis indicated that the brick aggregates have played a major role in improving the mechanical strength and permeability for better carbonation of the lime and hardly influenced hydraulicity. The comparative study of brick, brick-lime interface, and lime layer showed clear mineralogical and compositional changes. The bricks used as aggregates were fired at high fusion temperatures, destroying the crystalline structure of clay minerals and causing loss of pozzolanic activity due to reduced surface area and formation of high-temperature mineral phases. Studies indicate brick-lime inclusion in the plaster layers, and coarse brick aggregates fired at elevated temperature was specifically selected for underwater construction. The FTIR and thermal analysis indicate mixing a minor quantity of proteinaceous adhesive during plaster preparation, but organic additives like jute fibers were not added.
Risk Assessment and Monitoring of Certain Pollutants in Natural Honeys Imported from Different Countries and Marketing in KSA
Authors: Osman Khaled A , Mohamed Hala H Elsayed , Salama Maher S 
Published: July 2023

Abstract
Background
Natural honeys imported by Saudi Arabia and marketed in the local markets may do not comply with t national and international specifications and contain levels of metals and pesticide residues that exceed maximum residue limits (MRLs). Based on these residue data, a risk assessment of consumer exposure was conducted.
Methods
Natural honeys were characterized depending on their physicochemical and antimicrobial properties, as well as metals and pesticide residue contents were analyzed using atomic absorption spectrometry (AAS) and gas chromatography-mass spectrometry (GC-MS) techniques, respectively. Furthermore, a risk assessment for contaminated honey consumption by humans was performed, using consumption data.
Results
A broad range of pesticides were detected in the samples. Most of the detected active ingredients were insecticides and fungicides. A considerable part of the detected pesticide residues exceeded the EU and Cuban MRLs. However, the deterministic risk assessment revealed that the consumer risk of pesticide exposure is low. Only in the maximum exposure scenario children and adults were exposed to methamidophos residues in tomatoes higher than the acceptable daily intake.
Results
The chemical composition of some of these honeys did not comply with most national and international specifications with spatial variations in their properties. Additionally, honey samples showed greater antimicrobial activities than all analyzed samples against osmophilic microorganisms, and the most sensitive microorganism was Aspergillus flavus. Pb and Cd were not detected in any of the tested samples. Cu levels were below the guideline value of 5 mg/kg, while Zn, Fe, and Ni levels in most of the imported samples did not comply with the legislation values of 5, 15, and 0.01-1.00 mg/kg, respectively, and may pose a health risk to consumers. Additionally, Mn was found in higher levels, which can be attributed either to the production stages of honey or the region from which the honey was taken. Additionally, the present results revealed that some pesticides are either banned or not recommended to be used inside hives to control Varroa mites and found in honey imported from Germany, Australia, and Turkey. The hazard indices for were less than one
Conclusion
Because the hazard indices all the detected pesticides residues were <1, therefore the consumption of these imported honeys could not pose a health risk for the Saudi population. It can be concluded that some metals and pesticide residues found in imported natural honey are not safe baseline levels for human consumption and may affect human health.
Changes in the epidemiological profile of pituitary stalk thickening among pediatric population in Chile during COVID-19 pandemic
Authors: Zepeda Diego , Guarda Francisco J. , Okuma Cecilia , Hernandez Maria Isabel 
Published: July 2023

Abstract
Purpose
Pituitary stalk thickening (PST) is a rare disease affecting mainly adults. Pediatric cases are infrequent. The aim of this study is to evaluate the frequency of pediatric patients with PST during the pandemic outbreak of COVID-19 in Chile and compare it with previous data.
Methods
A retrospective chart review was conducted in patients with PST diagnosed during COVID-19 outbreak. Patients <18 years with pituitary stalk width of 3mm or more at pituitary insertion and/or 4mm or more at optic chiasm were included. In order to characterize and compare these cases with those already published, a review of the literature was performed.
Results
Nine patients were diagnosed with PST. Seven were girls. Mean age at the onset of symptoms was 10.36 years (2.4-17). Germinal cell tumors (GCT) were diagnosed in 8 patients and Langerhans cell histiocytosis in one. All patients had negative tumor markers, arginine-vasopressin deficiency (AVD) and at least one anterior pituitary hormonal deficit at diagnosis.
Diagnoses were confirmed histologically in all patients, and four required a second biopsy. We found a frequency of 4 patients per year with PST due to GCT which is twice the one expected in the same population in Chile.
Conclusion
A surprisingly high frequency of PST presented during the COVID-19 pandemic among Chilean pediatric patients, being GCT the most frequent etiology. The reasons behind this increase in reported cases are still to be elucidated.