bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS
Authors: Mau Theresa , Coen Paul , Kritchevsky Stephen , Newman Anne , Distefano Giovanna , Hepple Russell T , Goodpaster Bret , Cummings Steven 
Published: December 2022

Abstract
To assess mitochondrial function, max OXPHOS (maximal complex I and II supported state 3 respiration) was determined in vitro by high-resolution respirometry of permeabilized muscle fibers from thigh muscle (vastus lateralis) biopsies, and ATPmax was determined in vivo by 31P magnetic resonance spectroscopy (n=468, mean=76.9yr). Max OXPHOS was strongly associated with leg power (β= 10.7 Watts per 1 SD increment, p&lt;0.001) and peak VO2 (β= 83.7 mL/min, p&lt;0.001). ATPmax had weak associations with leg power (β= 4.2 Watts per SD increment, p=0.13). In contrast to its weaker relationship with leg power, ATPmax was strongly associated with VO2 peak (β= 70.1 mL/min per SD increment, p&lt;0.001). Skeletal muscle mitochondrial energetics were significant determinants of leg power and VO2 peak in older adults.
PRELIMINARY SOMMA DATA: D3CR MUSCLE MASS AND STRENGTH AND WALKING SPEED IN OLDER MEN AND WOMEN
Authors: Cawthon Peggy , Kritchevsky Stephen , Newman Anne , Mau Theresa , Hepple Russell T , Coen Paul , Goodpaster Bret , Cummings Steven 
Published: December 2022

Abstract
D3Cr muscle mass, grip strength, leg extension 1-rm max (Keiser), and walking speed (400m usual walk) were collected with standardized protocols. We calculated sex-stratified unadjusted Pearson correlation coefficients, and partial Pearson correlation coefficient adjusted for body size (height, weight). D3Cr muscle mass was positively correlated with grip strength (men: unadjusted r=0.28, p&lt;.001; women: unadjusted r=0.16, p=0.02) and leg extension strength (men: unadjusted r=0.44, p&lt;.001; women: unadjusted r=0.31, p&lt;.001). D3Cr muscle mass was correlated with 400-m walk speed only after adjustment for body size among both men (partial r=0.29, p&lt;.001) and women (partial r=0.16, p=0.02). Associations of total thigh muscle volume by MRI with strength and walking speed were of similar magnitude to the association between D3Cr muscle mass with strength and walking speed.
TWO DECADES EVALUATING EXERCISE TREATMENTS FOR ALZHEIMER'S DISEASE: THE ANECDOTES OF AN EVIDENCE-BASED PATH
Authors: Heyn Patricia 
Published: December 2022

Abstract
The last 20 years have produced accumulative evidence supporting the benefits of regular exercise to improve cognition in older adults with cognitive impairments (OAwCIs). Thus, multiple systematic reviews, including meta-analyses, have contributed to the current literature. Although the field advanced significantly our understanding of the role of exercise on AD, still there is limited information on the overall prescription effectiveness. Thus, a novel overview review to evaluate the available meta-analysis studies from the randomized exercise trials for OAwCI will help in synthesizing the best evidence to generate prescription precision. Dr. Heyn will discuss her path, her studies, and the future of AD research and exercise prescription.
AN INNOVATIVE MEDICAL LEGAL PARTNERSHIP TO SERVE COMMUNITY-DWELLING OLDER ADULTS
Authors: Lessem Rachel , Groman Tamara Kushnir 
Published: December 2022

Abstract
According to the Legal Services Corporation, each year, 56% of older adults have at least one civil legal problem yet 87% receive inadequate or no professional legal help for their civil legal problems. Unmet legal needs can have cascading catastrophic effects on the health and well-being of older adults. To address this, we took the innovative approach of creating a Medical-Legal Partnership (MLP) within a community based social service agency on aging. MLPs have been successful by addressing the social determinates of health. However, previous studies have not investigated MLPs aimed at older adults. We used a single arm, pretest-posttest design to investigate the effects and feasibility of providing legal services to community dwelling older adults. The MLP served over 88 clients referred both internally from the agency as well as external partners. The participants had a mean age of 73, (age range 45-98, n=88), were 60% female. African Americans represent 9% of the clients, 7% are Hispanic/Latino and 74% Caucasian. Additionally, 5% were veterans. 52% of clients were at or below the Federal Poverty line at baseline. 50% of clients reported greater financial stability as a result of legal services. 75% reported improved health of between 1 and 3 points on a 5 point likert scale (pre-test=2.75; post-test 3.9 p&lt;.01). This pilot project demonstrates a successful intervention to work across professional silos coordinating lawyers, medical providers and social workers to better meet the legal needs of older adults by creating MLPs in social service agencies to support their well-being.
DOES RACE MATTER IN HEALTH MESSAGING? IMPACT OF RACE CONCORDANCE ON PALLIATIVE CARE KNOWLEDGE SCORE
Authors: Hoe Deborah , Zhang Mutian , Enguidanos Susan 
Published: December 2022

Abstract
Palliative care (PC) programs have expanded rapidly across the United States in the last decade. However, there remains a wide disparity in access to PC among ethnic minorities. Therefore, it is necessary and critical to develop specific health-related educational tools targeted for the vastly diverse, community-based older adult population. This study seeks to investigate how race concordance in health-related messaging might affect changes in PC knowledge scores among Black and White, English-speaking, community-based adults aged 50 and older. We recruited 406 Black and White adults online and from community-based sites. Sixty-four percent were shown race concordant patient stories, the remainder were shown videos of opposite race patients. Pretest-posttest study design was employed and participants completed a 20-question survey about PC knowledge, intent to seek PC, and perceptions about the videos. Regression analysis was conducted to test if race concordance improved knowledge after viewing patient stories.PC knowledge score (max=13) improved from an average of 5.70 to 11.23 (t=23.2, p&lt; 0.001). Participants that watched same-race videos for both Black and White registered greater significant score increases (White:1.26±0.36 points, p=0.001; Black:0.95±0.38 points, p&lt; 0.05) compared with those who watched different-race videos. Further, intent to enroll oneself in PC revealed statistically significant relationships in all groups except among White participants who viewed different-race videos (p=0.157, Fisher’s exact test, two-tailed). This study suggests that while PC role model stories improved PC knowledge across the board, the improvement is greater in race concordant groups, which also has implications for changes in intent to enroll in PC.
EVALUATING IMPLEMENTATION COSTS FOR A TRANSITIONAL PALLIATIVE CARE INTERVENTION TO SUPPORT RURAL CAREGIVERS
Authors: Kaufman Brystana , Holland Diane , Vanderboom Catherine , Ingram Cory , Chun Alice , Langan Erica , Baer-Benson Henry , Griffin Joan 
Published: December 2022

Abstract
Compared to urban caregivers, rural caregivers experience greater burdens accessing coordinated care for their loved ones during and after hospital discharge. The impact of technology-enhanced transitional palliative care (TPC) on patient and caregiver outcomes is currently being evaluated in a randomized control trial. This study evaluates resource use and health system costs of this caregiver-focused TPC intervention. Rural caregivers of hospitalized patients in Minnesota, Wisconsin, and Iowa were enrolled in an 8-week intervention consisting of video visits, conducted by a registered nurse, supplemented with phone calls and texts (n=207). Labor costs were estimated using the Bureau for Labor Statistics median hourly rate for a registered nurse and compared to a scenario analysis using a nurse practitioner or social worker wages. Hours spent conducting the visits and charting were calculated using study data. A one-way sensitivity analysis estimated resource use over a range of visits per caregiver and time per visit. Caregivers received 8.8 visits on average over the study period at 45 minutes per visit. In the base case, TPC cost $330 per caregiver facilitated by a registered nurse, compared to $281 and $489 if facilitated by a social worker or nurse practitioner, respectively. The number of visits had the greatest influence on total costs of the intervention (low of $198, high of $463). TPC is a feasible, low cost strategy to enhance caregiver support in rural areas. These results pose an opportunity to consider reimbursement mechanisms to evaluate the sustainability of transitional palliative care interventions to support caregivers.
AGING-RELATED HUMAN MONOCYTE TRANSCRIPTOMIC PATHWAYS PREDICT WORSENING MULTIMORBIDITY
Authors: Ding Jingzhong , Lohman Kurt , Bertoni Alain , Shea Steven , Post Wendy , Pankow James , Kritchevsky Stephen , Liu Yongmei 
Published: December 2022

Abstract
In a cross-sectional analysis, we identified aging-associated monocyte transcriptional modules associated with the multimorbidity in the Multi-Ethnic Study of Atherosclerosis (MESA) study. Here we examine whether these modules predict worsening multimorbidity over time. Transcriptomic profiles were determined in circulating monocytes from 1,264 MESA participants aged 55-94 (51% female, 53% minority). The multimorbidity index was defined as the number of prevalent diseases: cardiovascular disease, type-2 diabetes, hypertension, cancer, dementia, chronic kidney disease, chronic obstructive pulmonary disease, and hip fracture. The mean index at baseline was 1.0 (33%, 45%, and 22% with 0, 1, and 2-6 diseases respectively). At baseline, the index was associated with 5 co-expressed transcriptional modules (FDR&lt; 0.05). During a 6-year follow-up, 449 individuals developed new morbidities. In Cox proportional hazards regression models, 4 (p&lt; 0.05) of these 5 modules including those enriched for downregulation of apoptosis (RH=1.11 per SD increment, p=0.03) and upregulation of complement subcomponent C1q (RH=1.14, p=0.005) predicted incident morbid diseases after adjusting for age, sex, race/ethnicity, study site, and the baseline multimorbidity index. Persons having above the median expression of both modules developed an average of 0.63 new diseases, while those with both below the median developed an average of 0.40 new diseases. These two modules predicted increasing morbidities independently of one another and IL6 levels (p&lt; 0.05). In conclusion, transcriptomic analysis of human immune cells provided evidence that decreased apoptosis and increased immune response predict the onset of a variety of age-related diseases. Whether targeting these pathways will change morbidity risk remains to be demonstrated.
EIGHT-YEAR CHANGES IN DEFICIT ACCUMULATION FRAILTY: RELATION TO GLYCEMIC CONTROL AND DIABETES MEDICATION USE
Authors: Simpson Felicia , Boyko Edward , Ferris Chloe , Justice Jamie , Kritchevsky Stephen , Mccaffery Jeanne , Pilla Scott , Espeland Mark 
Published: December 2022

Abstract
Type 2 diabetes mellitus (T2DM) has been linked to accelerated biological aging and the accumulation of health deficits. It is unknown whether glycemic control can slow the progression of aging, as expressed by deficit accumulation frailty indices (FIs). We examined the cross-sectional and longitudinal associations that glycemic control, diabetes medication use, and weight change (predictors) had with a FI calculated as the percent of 36 deficits in behavioral, functional, and clinical characteristics (outcome). We drew data from 4177 participants across 8 years of follow-up in the Look AHEAD clinical trial of a multidomain intensive lifestyle intervention in individuals aged 45-76 years with T2DM and overweight or obesity. At baseline, the means(SD) FI(as a percent) for participants grouped as HbA1c&lt; 7%, 7-7.9%, and &gt;8% were: 19.93(6.45), 20.82(6.89), and 21.53(7.27), p&lt; 0.001. Compared with HbA1c&gt;8%, HbA1c&lt; 7% at baseline was associated with 23% less mean 8-year FI progression: 2.42(7.35) vs 3.14(8.02), p&lt; 0.001). Maintaining average HbA1c&lt; 7% vs &gt;8% during follow-up was associated with 47% less 8-year FI progression: 2.05(7.35) vs 3.14(8.02), p&lt; 0.001. With adjustment for HbA1c, sustained weight loss &gt;5% compared with weight gain &gt;5% was associated with an 81% reduction in 8-year FI progression: 1.18(7.25) vs 3.89(8.09), p&lt; 0.001. Use of metformin across &gt;50% of annual visits was associated with a 30% reduction in 8-year progression of FI as compared with less use or no use: 2.25(7.27) vs 3.22(7.90), p=0.002. We conclude that better control of HbA1c, and sustained weight loss (&gt;5%) and metformin use, may slow the accelerated aging associated with T2DM.
PREPARING FOR THE FUTURE OF TECHNOLOGY TO SUPPORT OLDER ADULTS: PERSPECTIVES FROM THE CREATE CENTER
Authors: Heyn Patricia 
Published: December 2022

Abstract
The rapid advancement of technology promises new opportunities to help older adults maintain health, wellbeing, community and productive engagement, and purpose in life. However, the potential of technological innovation will not be met unless technology solutions account for the needs, preferences, and abilities of older users and involve older adults in all stages of the design process. This has been the primary focus of the Center for Research and Education on Aging and Technology Enhancement (CREATE). This symposium will discuss threats to the promise of these solutions and approaches to overcome these barriers. This session will start with N. Charness presenting an overview of digital inequity and the current state of the age-related "digital divide." J. Sharit will then present an experimental study examining older adults' willingness to adopt new technologies and attitudinal barriers to adoption. W. Boot will discuss CREATE research that has focused on the potential of virtual reality to improve the lives of older adults and potential facilitators and barriers to successful virtual reality experiences among older adults. W. Rogers will discuss the potential of voice interfaces for emerging technologies, challenges related to the success of this approach, and research gaps. Finally, S. Czaja will conclude with a broad discussion of future applications of technology to support older adults, including how developments in artificial intelligence, sensing technologies, and robotics that can be used to foster everyday activities, cognitive, physical, and emotional health.
ACHIEVING DIGITAL EQUITY FOR OLDER PERSONS WITH EMERGING TECHNOLOGY: THE CASE OF NORTH AMERICA
Authors: Charness Neil 
Published: December 2022

Abstract
The United Nations’ theme for the International Day of Older Persons 2021 was “Digital Equity for All Ages”. I define digital equity, then compare progress in North America, focusing on Canada, the USA, and Mexico for internet, smartphone, and broadband access. An age-related digital divide for internet and computer use, first identified in the USA in 1999, persists. Where year-to-year comparisons are available, I also discuss the impact of the pandemic on technology adoption. National data sets measuring internet use show that there are similarities and differences in the USA and Canada in factors influencing adoption. For smartphone ownership, Mexico showed gender differences favoring men, unlike the case in the USA and Canada. For broadband access in the USA inequity was seen as a function of age, race/ethnicity, education and income, and urban/rural residence. I discuss potential reasons for inequitable access and potential approaches to achieve greater equity.
OLDER ADULTS' WILLINGNESS TO ADOPT TECHNOLOGIES: AN EXPERIMENTAL STUDY
Authors: Sharit Joseph , Moxley Jerad , Czaja Sara 
Published: December 2022

Abstract
Understanding why older adults are willing to consider using technology is critical for ensuring that that the advantages of technology for improving the quality of their lives can be realized. Prior emphasis in this area has primarily been on questionnaire studies directed at capturing relatively general attitudes older adults have toward technology. We report on an empirical study that included 187 male and female adults 65-92 years of age who were given presentations on each of five technologies spanning domains that included transportation, leisure, health, and new learning. Each presentation was followed by a series of ratings on measures hypothesized to influence participants’ willingness to adopt the technology. We will overview the Technology Assessment Procedure, the methodology developed to evaluate willingness to adopt a technology, and measures that were collected. We will also present a model used to predict willingness to adopt the technology and provide some initial findings.
STRATEGIES FOR INTEGRATING ANTIRACIST PEDAGOGY INTO GERONTOLOGICAL EDUCATION
Authors: Karasik Rona , Kishimoto Kyoko 
Published: December 2022

Abstract
Talking about diversity in gerontology is not new. Documenting racial disparities among older adults is not new. So what is different about applying antiracist pedagogy to teaching about aging and why should gerontology educators embrace it? Anti-racist pedagogy seeks to move beyond simply incorporating racial content into gerontology coursework. It involves acknowledging structural racism’s existence and relation to aging, uncovering its root causes in historical and political context, and studying its impact not just over the life course, but from generation to generation. Anti-racist pedagogy challenges students to learn how racial disparities among older adults emerged, why they persist, and what can be done about them. Applying anti-racist pedagogy can also challenge gerontological educators, who must find/prepare appropriate materials, as well as engage students in work that is potentially unfamiliar and/or uncomfortable. This presentation offers some strategies, examples, and pitfalls to avoid when incorporating anti-racist pedagogy into the gerontological curriculum.
EXPLORING DEI IN A GLOBAL PERSPECTIVE: AGHE INSIGHTS INTO OUR WORK SUPPORTING GERONTOLOGY AND GERIATRIC EDUCATORS
Authors: Bradley Dana , Howe Judith 
Published: December 2022

Abstract
Gerontologists across the globe make a sincere effort to create a learning, teaching, and research space that promotes the dignity of older persons. Indeed, this impetus imbues our work where all are treated with dignity and respect. The authors (AGHE chair and past chair) reached out to international educators to better understand how AGHE is supporting their efforts and how we may do so in the future. Our starting point was the GSA policy on Diversity, Equity, and Inclusion (2021). These policies laid out a groundwork that embraces inclusive membership cultivates practices that build a culturally inclusive workforce, foster research practices, and ensure that people from disproportionately affected and marginalized communities thrive in GSA. This paper offers insight into how our international community is thinking about DEI and incorporating it into teaching, research and engagement work.
REIMAGINING ADRD IN CONTEXT
Authors: Ajrouch Kristine , Antonucci Toni , Martin Damali 
Published: December 2022

Abstract
This symposium embraces diversity and discovery to address contextual issues in aging, specifically issues of race and ethnicity in the study of cognitive health and Alzheimer's Disease and Related Dementia (ADRD). Rooks and colleagues compare dementia risk among African American and White men and women in the context of work using the longitudinal Health, Aging, and Body Composition data. They consider the effects of productive activities on dementia risk in gender stratified models, adjusting for socio-demographic and genetic factors. Siddiq and colleagues consider the contexts of migration. Using a multi-method approach, they establish priorities for interventions addressing ADRD risk among older adult immigrants and refugees from Afghanistan and the Middle-East and North Africa (MENA) in California. Sayed also investigates the context of migration, and uses qualitative data (N=31) to identify the psychosocial impact of COVID-19 on cognitive aging in Middle Eastern/Arab Americans immigrants and refugees in Michigan. Finally, Meier and colleagues consider contexts of metal exposure for cognitive decline among Latinos aged 65 and older using the Sacramento Area Latino Study on Aging. In total, this symposium highlights the benefits of reimagining contextual factors that influence ADRD to improve our understanding and the potential to reduce health disparities research in underrepresented racial and ethnic populations.
ALZHEIMER'S DISEASE AND RELATED DEMENTIAS RISK AND PSYCHOSOCIAL HEALTH NEEDS OF OLDER ADULT IMMIGRANTS AND REFUGEES
Authors: Siddiq Hafifa , Kayali Nahla , Ajrouch Kristine 
Published: December 2022

Abstract
To establish priorities for an intervention addressing Alzheimer’s Disease and Related Dementias (ADRD) risk among older adult immigrants and refugees from Afghanistan and the Middle-East and North Africa (MENA). A multi-methods Community-Based Collaborative Action Research design was employed to gather qualitative and quantitative data. Twenty community leaders and stakeholders participated in interviews and community needs survey responses of 124 ethnically diverse adults over age 55 were examined. We analyzed community needs survey data using descriptive statistics. A step-wise Thematic Analysis was used to analyze interview transcripts. A major theme and standout priority was identified: needing culturally-sensitive services and resources addressing social isolation among the elderly. Other psychosocial priorities included: accessibility needs, caregiving support, safety and end-of-life resources, digital literacy, and English language services. This study exemplifies a priority-setting partnership between clinician-researchers and refugee service providers. The priorities highlighted ADRD risk factors and guide the collaborative development of a community-based intervention.
IMPACT OF OBJECTIVE AND SUBJECTIVE SEP ON AGING TRAJECTORIES OF FUNCTIONAL CAPACITY
Authors: Finkel Deborah , Nilsen Charlotta , Sindi Shireen , Kåreholt Ingemar 
Published: December 2022

Abstract
Long-term stress is associated with adverse health outcomes in aging. It is important to identify not only factors that influence functioning in late adulthood, such as accumulated stress, but also the timing of such factors. The aim of the current analysis was to examine how socioeconomic stressors throughout the life course are associated with aging in functional capacity. Data were available from 740 adults ranging in age from 40 to 83 at intake (mean = 62.4, SD = 8.2) who participated in up to 8 waves of data collection (mean = 3.9, SD = 2.4). A Functional Aging Index (FAI) was created by combining measures of sensory, pulmonary, gait, and grip functioning. Both childhood and adulthood measures of objective socioeconomic position (SEP) and perceived SEP (financial strain) were available. Latent growth curve models (corrected for twinness) were used to estimate the trajectory of change in FAI over age and the impact of child and adult SEP measures on the trajectories. Results indicated that both childhood and adult objective SEP independently influenced rates of change in FAI in adulthood: higher SEP was associated with higher mean functioning and slower rates of decline. In combination, model fitting indicated that if SEP is above the median in adulthood, then childhood SEP has no impact on FAI trajectories; however, if SEP is below the median in adulthood, then childhood SEP can play a role. In addition, results indicated possible long-term effects of childhood financial strain on rates of change in FAI in adulthood.