bluuebunny/crossref_metadata_2025_split huggingface dataset:
A transitions framework for circular business models
Authors: Susur Ebru , Engwall Mats 
Published: December 2022

AbstractThe concepts “circular business models” and “transitions towards a circular economy” have become modern‐day buzzwords. Yet, an understanding of the interplay between these two concepts remains unclear. This paper proposes a conceptual framework that illustrates the innovation mechanisms enhancing circular business models emerging within the context of transitions towards a circular economy. The paper follows a two‐step methodology. First, a theoretical framing is proposed by adopting insights from transitions studies. Second, a systematic literature review is employed. The review synthesizes the selected literature tracing the proposed framing in the previously published research. Finally, a transitions framework for circular business models is proposed. This framework suggests future lines of research to support its plausibility. Moreover, it offers prescriptive help to managers, entrepreneurs, policymakers, and other social actors enabling them to make informed decisions about and take innovative actions for circular business models in specific contexts.
Recent developments on trade and inequality
Authors: Dai Mi 
Published: December 2022

AbstractThis paper surveys developments in the literature on trade and inequality over the past decade. I first discuss the impact of trade on nominal income inequality, with a focus on firm heterogeneity and the role of mobility frictions. Then, I provide an overview of the literature on the redistributional role of government in an open economy. Finally, I assess the current state of studies on how trade affects real income inequality through the expenditure channel.
Language otherwise: Linguistic natures and the ontological challenge
Authors: Hauck Jan David 
Published: December 2022

AbstractLinguistic anthropology has remained largely unaffected by debates about ontology in other subfields. In turn, the concept of language has been conspicuously absent from ontological debates. The past few years, however, have seen attempts at articulating the two, interrogatingwhat language isfrom ethnographic perspectives and extending the analytic focus toontologies of languageorlinguistic natures. This article discusses such efforts and compares them to previous critical engagements with the concept of language. Calling into question the ontological equivalence of language within and across cultures, communities, and regions, it explores understandings of what language is that go against the grain of existing theoretical models.
The over‐expression of miRNA‐206 in peripheral blood of patients with burning mouth syndrome and its relationship with anxiety and depression
Authors: Fang Meifei , Huang Yuxiao , Li Chen , Liu Jiaxuan , Ya Zuke , Mei Guocheng , Tao Renchuan , Jiang Lanlan 
Published: December 2022

AbstractBackgroundBurning mouth syndrome (BMS) is characterised by persisting burning pain of the oral mucosa, and its etiopathogenesis remains poorly understood.ObjectivesOur study aimed to detect the expression of miRNA‐206 in the blood and clarify the relationship among miRNA‐206, pain, anxiety and depression of BMS patients.MethodsThirty patients with BMS and 30 healthy individuals were enrolled in the experimental and control groups, respectively. Data on medical history and clinical oral examination for all participants were collected. Simultaneously, scores of Visual Analogous Scale (VAS), Self‐rating Anxiety Scale (SAS) and Self‐rating Depression Scale (SDS) were administered. The expression level of miRNA‐206 in plasma were determined by RT‐(q)PCR. Finally, the relationship of miRNA‐206 expression with the VAS score, SAS score, and SDS score was analysed. Chi‐square test and t‐test were used for statistical analysis of the data, and p < .05 was considered statistically significant.ResultsThe majority of the patients with BMS identified the tongue as the main pain area, and showed dry mouth and poor sleep quality. The SAS and SDS scores of patients with BMS were higher than those of healthy controls (p < .05) and were positively correlated with VAS pain score. In addition, miRNA‐206 expression was higher in patients with BMS than in healthy individuals (p < .05), and was positively correlated with the VAS and SDS scores (p < .05).ConclusionsPatients with BMS suffer from pain and tend to be more anxious and depressed than healthy controls. miRNA‐206 expression in the peripheral blood of patients with BMS is positively correlated with pain and depression, which may be involved in the pathogenesis of BMS.
Evaluation of the perceptions, attitudes, and knowledge of consumers in the south region of Brazil regarding vinegars: Potential application of regional fruits
Authors: da Silva Monteiro Wanderley Bruna Rafaela , Dias de Mello Castanho Amboni Renata , Moura de Sena Aquino Ana Carolina , Beddin Fritzen‐Freire Carlise 
Published: December 2022

AbstractAlthough vinegar has been consumed since ancient times, the demand for developing this product from unconventional fruits has increased in recent years. Therefore, the goal of this study was to evaluate the perception of consumers in the South Region of Brazil regarding vinegar and explore the potential of regional raw materials for its production. The study was carried out with a total of 1,970 participants using an online questionnaire divided into five sections. Through word association technique, it was noted that age group influenced on the perception experienced by those participants who are regular consumers of vinegar regarding its attributes and properties. Moreover, the type of vinegar consumed was correlated with the income of the participants. Moreover, some fruits native to the South Region of Brazil, such as jaboticaba, orange passion fruit, red araçá, uvaia, guabiroba, and feijoa, showed great potential for application in vinegar production.Practical applicationsThis study identified the factors that influence on consumer perception experienced by people who regularly consume vinegar, as well as their attitudes related to its use, consumption, and application. Besides, it showed the importance of applying new raw materials in the vinegar preparation process, highlighting the potential of native fruits from the South Region of Brazil, thus providing relevant information for the vinegar market and an opportunity for the development of new products.
Liver transplantation for autoimmune hepatitis: Pre‐transplant does not predict the early post‐transplant outcome
Authors: Chouik Yasmina , Francoz Claire , De Martin Eleonora , Guillaud Olivier , Abergel Armand , Altieri Mario , Barbier Louise , Besch Camille , Chazouillères Olivier , Conti Filomena , Corpechot Christophe , Dharancy Sébastien , Durand François , Duvoux Christophe , Gugenheim Jean , Hardwigsen Jean , Hilleret Marie‐Noëlle , Houssel‐Debry Pauline , Kamar Nassim , Minello Anne , Neau‐Cransac Martine , Pageaux Georges‐Philippe , Radenne Sylvie , Roux Olivier , Saliba Faouzi , Samuel Didier , Vanlemmens Claire , Woehl‐Jaegle Marie‐Lorraine , Leroy Vincent , Duclos‐Vallée Jean‐Charles , Dumortier Jérôme 
Published: December 2022

AbstractBackground and AimsAutoimmune hepatitis (AIH) is a rare indication (<5%) for liver transplantation (LT). The aim of this study was to describe the early outcome after LT for AIH.MethodsA multicenter retrospective nationwide study including all patients aged ≥16 transplanted for AIH in France was conducted. Occurrences of biliary and vascular complications, rejection, sepsis, retransplantation and death were collected during the first year after LT.ResultsA total of 344 patients (78.8% of women, 17.0% of (sub)fulminant hepatitis and 19.2% of chronic liver diseases transplanted in the context of acute‐on‐chronic liver failure [ACLF]) were included, with a median age at LT of 43.6 years. Acute rejection, sepsis, biliary and vascular complications occurred in respectively 23.5%, 44.2%, 25.3% and 17.4% of patients during the first year after LT. One‐year graft and patient survivals were 84.3% and 88.0% respectively. The main cause of early death was sepsis. Pre‐LT immunosuppression was not associated with an increased risk for early infections or surgical complications. Significant risk factors for septic events were LT in the context of (sub)fulminant hepatitis or ACLF, acute kidney injury at the time of LT (AKI) and occurrence of biliary complications after LT. AKI was the only independent factor associated with graft (HR = 2.5; 95% CI: 1.1–5.4; p = .02) and patient survivals (HR = 2.6; 95% CI: 1.0–6.5; p = .04).ConclusionEarly prognosis is good after LT for AIH and is not impacted by pre‐LT immunosuppression but by the presence of AKI at the time of LT.
Detection of ferric iron in an exsolved lunar pyroxene using electron energy loss spectroscopy (EELS): Implications for space weathering and redox conditions on the Moon
Authors: Cymes Brittany A. , Burgess Katherine D. , Stroud Rhonda M. 
Published: December 2022

AbstractTo shed light on the mechanism of formation of nanophase iron particles (npFe) in space‐weathered materials from airless bodies, we analyzed exsolved and unexsolved space‐weathered lunar pyroxenes from Apollo 17 sample 71501. The exsolved pyroxene allowed for the observation of the effects of space weathering on similar mineral phases with variable composition. Using coordinated scanning transmission electron microscopy with energy‐dispersive X‐ray spectroscopy and electron energy loss spectroscopy (EELS), we determined that two coexisting pyroxenes in the exsolved grain showed systematic variations in response to space weathering, despite equivalent exposure conditions. The npFe in the space‐weathered rim of augite lamellae were smaller and fewer than the npFe in the rim of pigeonite lamellae. EELS spectrum imaging revealed the presence and heterogeneous distribution of Fe0, Fe2+, and Fe3+ in the exsolved pyroxene. Metallic iron occurred in the npFe, a mixture of Fe2+ and Fe3+ occurred in the pigeonite lamellae, and the augite lamellae contained virtually all Fe3+. Approximately 50% of the total Fe measured in the exsolved pyroxene grain was ferric. Partitioning of Fe2+ and Fe3+ among the lamellae is invoked to explain the difference in npFe development in pigeonite and augite. The results of this study, the first to identify Fe3+ in a crystalline lunar ferromagnesian silicate, have implications for our understanding of how space weathering might proceed in oxidized phases. Furthermore, the discovery of an Fe3+‐rich pyroxene also supports attribution of the 0.7 μm absorption feature observed in Galileo Solid State Imager data to oxidized Fe in clinopyroxenes.
Atypical life cycle does not lead to inbreeding or selfing in parasites despite clonemate accumulation in intermediate hosts
Authors: Keeney Devon B. , Cobb Sarah A. , Jadin Robert C. , Orlofske Sarah A. 
Published: December 2022

AbstractMany parasites utilize asexual and sexual reproduction and multiple hosts to complete their life cycles. How these taxa avoid inbreeding is an essential question for understanding parasite evolution and ecology. Aquatic trematodes that require multiple host species may benefit from diverse genetic parasite assemblages accumulating within second intermediate hosts prior to sexual reproduction in definitive hosts. However, Cotylurus species are able to utilize the same snail species as first and second intermediate hosts, potentially resulting in the accumulation of genetically identical clones (clonemates) prior to sexual reproduction. In this study, we developed and analysed novel microsatellite loci to determine if clones are accumulating within snail hosts prior to ingestion by bird hosts and the effects this could have on parasite inbreeding. Contrary to previous studies of aquatic trematodes, significantly large numbers of clonemates were present within snails, but full‐sibs were not. Genetic structure was present over a relatively small geographical scale despite the use of vagile definitive hosts. Phylogenetic analysis identified the Cotylurus sp. clones as belonging to a single species. Despite the presence of clones within snails, mating between clones/selfing was not common and heterozygosity is maintained within individuals. Potential issues with clones mating may be mitigated by the presence of snails with numerous clones, the consumption of many snails by bird hosts and parasite clone recognition/avoidance. Use of the same host species for multiple life stages may have advantages when parasites are able to avoid inbreeding and the required hosts are common.
Mycobacterium tuberculosis induces delayed lipid droplet accumulation in dendritic cells depending on bacterial viability and virulence
Authors: Costa Maria Fernanda de Souza , Pereira‐Dutra Filipe , Deboosere Nathalie , Jouny Samuel , Song Ok‐Ryul , Iack Guilherme , Souza Andreia Lamoglia , Roma Eric Henrique , Delorme Vincent , Bozza Patricia T. , Brodin Priscille 
Published: December 2022

AbstractTuberculosis remains a global health threat with high morbidity. Dendritic cells (DCs) participate in the acute and chronic inflammatory responses to Mycobacterium tuberculosis (Mtb) by directing the adaptive immune response and are present in lung granulomas. In macrophages, the interaction of lipid droplets (LDs) with mycobacteria‐containing phagosomes is central to host‐pathogen interactions. However, the data available for DCs are still a matter of debate. Here, we reported that bone marrow‐derived DCs (BMDCs) were susceptible to Mtb infection and replication at similar rate to macrophages. Unlike macrophages, the analysis of gene expression showed that Mtb infection induced a delayed increase in lipid droplet‐related genes and proinflammatory response. Hence, LD accumulation has been observed by high‐content imaging in late periods. Infection of BMDCs with killed H37Rv demonstrated that LD accumulation depends on Mtb viability. Moreover, infection with the attenuated strains H37Ra and Mycobacterium bovis‐BCG induced only an early transient increase in LDs, whereas virulent Mtb also induced delayed LD accumulation. In addition, infection with the BCG strain with the reintroduced virulence RD1 locus induced higher LD accumulation and bacterial replication when compared to parental BCG. Collectively, our data suggest that delayed LD accumulation in DCs is dependent on mycobacterial viability and virulence.
Clinical development of novel therapies for Duchenne muscular dystrophy—Current and future
Authors: Tominari Tsukasa , Aoki Yoshitsugu 
Published: December 2022

AbstractDuchenne muscular dystrophy (DMD), the most common muscle degenerative disease, is an X‐linked genetic disorder caused by the loss or reduction of dystrophin protein, resulting in progressive muscle wasting, and involving skeletal, cardiac, and respiratory muscles. There is currently no cure for DMD, and an anti‐inflammatory steroid is the conventional treatment to delay disease progression. Recently, several therapeutic approaches have been developed to improve patient quality of life and even to treat the underlying cause of the disease. These approaches include exon‐skipping, stop‐codon read‐through, vector‐mediated gene therapy, and stem cell transplantation. Exon‐skipping is one of the most promising techniques, and four exon‐skipping drugs have received approval, including NS‐065/NCNP‐01 (viltolarsen) in Japan and the USA. The read‐through drug, Ataluren, has received approval in the EU. Vector‐mediated therapy and cell transplantation are also attractive approaches, and currently, clinical trials are ongoing for some drugs. Furthermore, several studies have developed innovative approaches for DMD treatment, such as multiple exon skipping, gene editing using the CRISPR/Cas9 system, and mesenchymal stromal cell (MSC)‐ or inducible pluripotent stem cell (iPSC)‐based cell transplantation. In this review, we summarize current therapeutic approaches for DMD treatment.
Chlorhexidine‐based versus non‐chlorhexidine dressings to prevent catheter‐related bloodstream infections: An evidence‐based review
Authors: Azzopardi Anthea , Trapani Josef 
Published: December 2022

AbstractIn patients with central venous catheters (CVCs) in situ, the development of catheter‐related bloodstream infections (CRBSIs) is often linked with increased morbidity and mortality. Sterile gauze or transparent polyurethane dressings are conventionally used as extraluminal barriers; however, antimicrobial chlorhexidine CVC dressings could potentially reduce infection risk. This short evidence‐based review examined the literature comparing the effectiveness of chlorhexidine‐based CVC dressings against non‐chlorhexidine dressings in reducing CRBSI occurrence. Four systematic reviews with meta‐analysis were reviewed, all of which reported a statistically significant reduction in CRBSI occurrence on using chlorhexidine‐based dressings. Further research is needed to determine the cost‐effectiveness of chlorhexidine‐based CVC dressings and their effectiveness in reducing CRBSIs in different catheter types and entry sites because infection risk is not uniform.
Chronic opioid users with dysphagia are indistinguishable from symptomatic nonusers on functional lumen imaging probe evaluation
Authors: Patel Devan , Khodadadi Alexandra , Jadcherla Aditya , Rengarajan Arvind , Rogers Benjamin D. , Gyawali C. Prakash 
Published: December 2022

AbstractBackgroundOpioid‐induced esophageal dysmotility (OIED) includes spastic esophageal motility disorders, increasingly recognized in the contemporary opioid epidemic. We assessed functional lumen imaging probe (FLIP) findings in diagnosing OIED.MethodsSymptomatic patients undergoing FLIP with no prior foregut surgery who completed validated questionnaires were identified and segregated into chronic opioid users and nonusers in this cohort study. Esophagogastric junction (EGJ) distensibility index (DI), EGJ diameter, and esophageal body contraction patterns were extracted. Symptom profiles were compared to FLIP findings between chronic opioid users and nonusers. Outcome was evaluated in a subset using the same validated questionnaires.ResultsOver the 18‐months study period, of 116 patients (median age 62 years, 70.7% female), 33 (28.4%) were chronic opioid users, with median morphine milligram equivalent of 30 mg. While presenting symptoms were similar, chronic opioid users reported higher perceptive symptoms (p = 0.008) and worse quality of life (p = 0.01) compared to nonusers. Median DI trended lower in chronic opioid users (p = 0.08), with more retrograde repetitive contractions (p < 0.001) and less absent contractility (p = 0.007), but final FLIP diagnoses were similar compared to nonusers. There was no correlation between opioid dose and FLIP metrics. In the subset with follow‐up, perceptive symptoms trended higher in chronic opioid users (p = 0.08), but symptom improvement following therapy was similar in both groups.Conclusions & InferencesSymptomatic chronic opioid users have FLIP diagnoses that are similar to nonusers, despite higher perceptive symptoms and worse quality of life. Dominant symptoms improve both in chronic opioid users and nonusers following treatment directed by FLIP.
Comparative effectiveness of glucagon‐like peptide‐1 receptor agonists for the management of obesity in adults without diabetes: A network meta‐analysis of randomized clinical trials
Authors: Alkhezi Omar S. , Alahmed Abdullah A. , Alfayez Osamah M. , Alzuman Osama A. , Almutairi Abdulaali R. , Almohammed Omar A. 
Published: December 2022

SummaryTirzepatide is a new glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) that has shown promising results for weight loss. A Bayesian network meta‐analysis was conducted to compare the efficacy and safety of GLP‐1RAs for obesity management. Embase and MEDLINE were searched looking for randomized clinical trials (RCTs) that evaluated the efficacy of GLP‐1RAs for weight loss in patients without diabetes. The main efficacy outcomes evaluated were the mean change in actual and percentage weight loss and the proportion of patients with weight loss of ≥5%–20%. Main safety outcomes evaluated include nausea, vomiting, diarrhea, constipation, loss of appetite, pancreatitis, gallbladder‐related disorders, and withdrawal due to adverse events. Seven RCTs with more than 12,300 patients were analyzed, including patients with body mass index (BMI) ≥ 30 kg/m2, or BMI ≥ 27 kg/m2 with comorbidities. Weekly tirzepatide 10 and 15 mg resulted in more weight loss than weekly semaglutide 2.4 mg, daily semaglutide 0.4 mg, or liraglutide 3 mg. Tirzepatide and weekly semaglutide demonstrated comparable results but with significantly higher odds of achieving ≥5%–20% weight loss compared with liraglutide. GLP‐1RAs triggered more gastrointestinal adverse events than placebo, with no in‐between difference. Although all GLP‐1RAs lead to significant weight reduction, tirzepatide was associated with better efficacy outcomes while having a comparable safety profile.
Association of temporomandibular joint osteoarthrosis with dentoskeletal morphology in males: A cone‐beam computed tomography and cephalometric analysis
Authors: Zhang Qinlanhui , Gong Yanji , Liu Fang , Wang Jun , Xiong Xin , Liu Yang 
Published: December 2022

AbstractObjectiveThe objective of the study was to assess the differences in dentoskeletal morphology in males with and without temporomandibular joint osteoarthrosis (TMJOA).MethodsThree hundred seventy‐one male participants seeking orthodontic treatment were enrolled in this cross‐sectional study. Each participant's osseous status was evaluated using cone‐beam computed tomography (CBCT) and classified into normal (N = 104), indeterminate for TMJOA (N = 110) and TMJOA (N = 157) groups. The dentoskeletal characteristics were evaluated using cephalograms. Stratified analysis was performed based on age and skeletal pattern. Descriptive statistics and one‐way analysis of variance were performed to investigate dentoskeletal differences among groups. P < .05 was considered statistically significant.ResultsThe differences in posterior cranial base length, FMA, MP‐OP, anterior facial height, articular angle, ramus height and L1‐MP were statistically significant. After stratification by age, the differences in FMA, maxillomandibular angle, posterior facial height, facial height ratio, gonial angle and mandibular body length were statistically significant in adults. No statistical difference except for articular angle was observed in adolescents. After stratification by skeletal pattern, statistical differences were mainly apparent in skeletal Class II adults.ConclusionMales with TMJOA showed a posteriorly positioned and backward‐rotated mandible, especially in skeletal Class II adults. Compared with women, the craniofacial morphology of men is less affected by TMJOA. The association between TMJOA and craniofacial morphology also varied across different age groups and skeletal patterns. Prospective studies are required to clarify the cause–effect relationship between TMJOA and craniofacial morphology in males.