bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergy between Human Peptide LL-37 and Polymyxin B against Planktonic and Biofilm Cells of Escherichia coli and Pseudomonas aeruginosa
Authors: Ridyard Kylen E. , Elsawy Mariam , Mattrasingh Destina , Klein Darien , Strehmel Janine , Beaulieu Carole , Wong Alex , Overhage Joerg 
Published: February 2023

The rise in antimicrobial resistant bacteria is limiting the number of effective treatments for bacterial infections. Escherichia coli and Pseudomonas aeruginosa are two of the pathogens with the highest prevalence of resistance, and with the greatest need for new antimicrobial agents. Combinations of antimicrobial peptides (AMPs) and antibiotics that display synergistic effects have been shown to be an effective strategy in the development of novel therapeutic agents. In this study, we investigated the synergy between the AMP LL-37 and various classes of antibiotics against E. coli and P. aeruginosa strains. Of the six antibiotics tested (ampicillin, tetracycline, ciprofloxacin, gentamicin, aztreonam, and polymyxin B (PMB)), LL-37 displayed the strongest synergy against E. coli MG1655 and P. aeruginosa PAO1 laboratory strains when combined with PMB. Given the strong synergy, the PMB + LL-37 combination was chosen for further examination where it demonstrated synergy against multidrug-resistant and clinical E. coli isolates. Synergy of PMB + LL-37 towards clinical isolates of P. aeruginosa varied and showed synergistic, additive, or indifferent effects. The PMB + LL-37 combination treatment showed significant prevention of biofilm formation as well as eradication of pre-grown E. coli and P. aeruginosa biofilms. Using the Galleria mellonella wax worm model, we showed that the PMB + LL-37 combination treatment retained its antibacterial capacities in vivo. Flow analyses were performed to characterize the mode of action. The results of the present study provide proof of principle for the synergistic response between LL-37 and PMB and give novel insights into a promising new antimicrobial combination against gram-negative planktonic and biofilm cells.
Dynamics of Plasma Refill Rate and Intradialytic Hypotension During Hemodialysis: Retrospective Cohort Study With Causal Methodology
Authors: Wang Christina H. , Negoianu Dan , Zhang Hanjie , Casper Sabrina , Hsu Jesse Y. , Kotanko Peter , Raimann Jochen , Dember Laura M. 
Published: February 2023

Key Points

Directly studying plasma refill rate (PRR) during hemodialysis (HD) can offer insight into physiologic mechanisms that change throughout HD.PRR at the start and during HD is associated with intradialytic hypotension, independent of ultrafiltration rate.A rising PRR during HD may be an early indicator of compensatory mechanisms for impending circulatory instability.

Background
Attaining the optimal balance between achieving adequate volume removal while preserving organ perfusion is a challenge for patients receiving maintenance hemodialysis (HD). Current strategies to guide ultrafiltration are inadequate.

Methods
We developed an approach to calculate the plasma refill rate (PRR) throughout HD using hematocrit and ultrafiltration data in a retrospective cohort of patients receiving maintenance HD at 17 dialysis units from January 2017 to October 2019. We studied whether (1) PRR is associated with traditional risk factors for hemodynamic instability using logistic regression, (2) low starting PRR is associated with intradialytic hypotension (IDH) using Cox proportional hazard regression, and (3) time-varying PRR throughout HD is associated with hypotension using marginal structural modeling.

Results
During 180,319 HD sessions among 2554 patients, PRR had high within-patient and between-patient variability. Female sex and hypoalbuminemia were associated with low PRR at multiple time points during the first hour of HD. Low starting PRR has a higher hazard of IDH, whereas high starting PRR was protective (hazard ratio [HR], 1.26, 95% confidence interval [CI], 1.18 to 1.35 versus HR, 0.79, 95% CI, 0.73 to 0.85, respectively). However, when accounting for time-varying PRR and time-varying confounders, compared with a moderate PRR, while a consistently low PRR was associated with increased risk of hypotension (odds ratio [OR], 1.09, 95% CI, 1.02 to 1.16), a consistently high PRR had a stronger association with hypotension within the next 15 minutes (OR, 1.38, 95% CI, 1.30 to 1.45).

Conclusions
We present a straightforward technique to quantify plasma refill that could easily integrate with devices that monitor hematocrit during HD. Our study highlights how examining patterns of plasma refill may enhance our understanding of circulatory changes during HD, an important step to understand how current technology might be used to improve hemodynamic instability.
Diabetes associada a outras comorbidades como fator de risco para a progressão da Covid-19
Authors: Mendes Nicolas Daniel de Campos , Corrêa Carla Ediane Batista , Picoli Maria Eleonora Feracin da Silva , De Souza Alexandre Reis Taveira , Ananias Fernando 
Published: February 2023

Objetivo: Esse estudo teve como objetivo fazer uma análise do perfil dos casos de SRAG causadas pela COVID-19 em diabéticos durante o período de 15/março/20 a 15/março/21 na cidade de Campinas/SP, a fim de analisar as interações entre a diabetes e as co-comorbidades em relação a gravidade do caso e o desfecho final. Metodologia: Foram utilizadas as informações de pacientes com SRAG do Banco de Dados de Síndrome Respiratória Aguda Grave, incluindo dados da COVID-19 por acesso ao DATASUS, filtradas de acordo com as características alvo, casos confirmados de Covid-19, óbitos confirmados por Covid-19, evolução final do caso, idade, uso de suporte ventilatório, o tipo de suporte ventilatório utilizado e presença de comorbidades em não diabéticos, diabéticos apenas e diabéticos com alguma comorbidade. Resultados: Foi identificado um total de 7318 pacientes com SRAG e classificação final do caso SRAG por COVID-19. Dos casos notificados, 5196 (71%) não apresentavam DM, enquanto 2122 pacientes (29%) apresentavam diabetes como comorbidade, sendo essa porcentagem composta por 4% de pacientes apenas com DM e 25% pacientes com DM associada a alguma(s) comorbidade(s). Conclusão: Pacientes com COVID-19, diabéticos e que possuíam mais de uma comorbidade associada, foram os que mais necessitaram de suporte ventilatório apresentando uma prevalência de 53,2% para o suporte ventilatório invasivo, 39,2% para o não invasivo e 36,4% não necessitaram. Entre os não diabéticos o percentual de óbito foi de 23,96%, enquanto entre os diabéticos esse percentual subiu para 32,85%. A diabetes associada ou não a alguma comorbidade foi responsável por agravar o caso de pacientes com SRAG causada pela COVID-19, contribuindo para o óbito de pacientes.
Actitudes hacia la salud holística, complementaria y alternativa
Authors: Yaguana Johanna Lizbeth Jacho , Romo Yolanda Elizabeth López 
Published: February 2023

La medicina complementaria y alternativa es comprendida como el conjunto de conocimientos, aptitudes y prácticas que son utilizadas para la prevención, diagnóstico y tratamiento de enfermedades físicas y mentales, basándose en las experiencias de los pueblos originarios en todo el mundo, es decir en los conocimientos ancestrales. Con este antecedente el presente estudio tiene por finalidad determinar las actitudes hacia la salud holística, complementaria y alternativa de los habitantes de la comunidad Chambapongo, del Cantón Salcedo en la Provincia de Cotopaxi. Para el mismo se aplicó una metodología con enfoque cuantitativa, no experimental, transversal y de campo el instrumento de recolección de datos fue el formulario de medicina alternativa y complementaria, Holistic Complementary and Alternative Medicine Questionnaire (HCAMQ), tras la aplicación del mismo se realizó un análisis de los resultados obtenidos con el fin de Se puede concluir mediante los resultados obtenidos y análisis de los mismos que los moradores de la comunidad de Chambapongo tienen una actitud positiva hacia el uso de la medicina holística, complementaria y alternativa evidenciándose una mayor acogida en el ámbito no farmacológico para el manejo de enfermedades comunes.
Creación y validación del formato de valoración salud enfermero en paciente geriátrico
Authors: Juna Helen Lissette Pullutasig , Páez Marlene del Pilar Suárez 
Published: February 2023

Introducción: La población adulta mayor a nivel mundial se incrementa de forma acelerada estimando que a 2020 se hay alrededor de 1400 millones de personas, por ende, es preciso considerar los problemas de salud que afronta esta población ya que paulatinamente pierden la autonomía e independencia para realizar sus actividades diarias, de manera que en la atención primaria de la salud es preciso contar con un instrumento de valoración que permita diagnosticar las condiciones de salud del paciente geriátrico. Objetivo: Crear un instrumento de valoración salud enfermero para el paciente geriátrico. Metodología: La investigación se desarrolló con un enfoque experimental, con un diseño de corte transversal de tipo descriptiva, cuya población fueron los estudiantes de la Universidad Técnica de Ambato quienes aplicaron el instrumento a 101 pacientes geriátricos. De manera que el instrumento fue diseñado con 26 ítems bajo la escala de Barthel, la escala de incapacidad física de la Cruz Roja (EICR), el cuestionario Zung y la escala de valoración sociofamiliar de Gijón. Para aplicar el instrumento se efectuó un análisis de fiabilidad con el índice Alpha de Cronbach, al igual que fue sometido a la revisión de cuatro profesionales en el área de enfermería y geriátrica. Los datos recolectados fueron analizados en el programa estadístico SPSS. Resultados: Los resultados señalan que el formato de valoración salud enfermero en pacientes geriátricos alcanzó un índice Alpha de Cronbach de 0,799, con un tiempo de aplicación entre 3 a 5 minutos. Conclusión: El formato de valoración salud enfermero en pacientes geriátricos es un instrumento fiable para ser aplicado en el área de salud que permite realizar una valoración a nivel físico, funcional, psicológico y social, demostrando el nivel de dependencia de la persona en realizar actividades diarias, la salud mental de la persona y las condiciones sociofamiliares.
Sangramento gastrointestinal em paciente portador da Síndrome de Rendu-Osler-Weber: um relato de caso
Authors: Terceiro Neto Maria Beatriz Azevedo , Lima Mariana Lopes , Fernandes Milena Queiroga , Fialho Nathalia Maria Menezes , Coutinho Selda Rafaela Aguiar Ribeiro 
Published: February 2023

A síndrome de Rendu-Osler-Weber ou Telangiectasia Hemorrágica Hereditária (THH) é uma rara displasia fibrovascular de he­rança autossômica dominante caracterizada por um defeito na camada muscular da parede dos vasos sanguíneos que os torna mais vulneráveis a rupturas espontâneas, provocando sangramentos em pele e mucosas. Está relacionada com telangiectasias mucocutâneas e malformações arteriovenosas, que podem acometer vários órgãos e estão associadas a complicações a depender do local acometido. O diagnós­tico é confirmado através da presença de pelo menos 3 dos Critérios de Curação e o manejo apropriado depende do sítio de acometimento da doença. Em relação ao acometimento do trato gastrointestinal, o tratamento tem por objetivo diminuir os episódios de sangramentos e suas intensidades, podendo variar dentre endoscópicos, hormonais e antiangiogênicos. Esta síndrome é uma doença que muitos profissionais de saúde desconhecem devido a sua vasta gama de manifestações clínicas e apesar de ser uma patologia rara, deve ser considerada como um possível diferencial em casos de sangramento gastrointestinal ou anemia, principalmente quando as causas mais comuns foram descartadas.
Análise das intervenções farmacêuticas no processo de cuidados terapêuticos de idosos diabéticos e hipertensos
Authors: Barbosa Milena Vitória Carvalho , Dos Santos Andréia Nayara Araújo , Torres Sabrina Bezerra , Almeida Lucas Filipe da Silva , Silva Edvaldo Cícero da , Da Cruz Adyla Fernanda Silva , Cabral Analúcia Guedes Silveira , Monteiro Ana Catarina Simonetti 
Published: February 2023

A atenção farmacêutica é realizada por profissionais farmacêuticos, sendo realizada para avaliar resultados clínicos-laboratoriais e utilizar dos mesmos para melhor conduta junto ao usuário, intervindo na detecção, prevenção e solução de problemas relacionados à farmacoterapêutica. Tal intervenção tem destaque em sujeitos polimedicados, os quais utilizam diversos medicamentos de forma crônica e simultânea para doenças e sintomas distintos, tais pacientes são principalmente idosos, em decorrência da idade avançada e começam a apresentar mudanças fisiológicas. Desta forma, na atual pesquisa objetivou-se compreender a atuação farmacêutica junto a pacientes hipertensos e/ou diabéticos para verificar possíveis melhoras após a intervenção do farmacêutico. Trata-se de uma integrativa de literatura, de natureza qualitativa e exploratória, cuja busca de artigos foi realizada no ano de 2022, entre os meses de maio e junho, filtrando-se os que foram publicados entre os anos de 2017 a 2022, utilizando as bases de dados, Pubmed, ScienceDirect, e BIREME, com o uso dos Descritores em Ciência da Saúde (DeCS): “Diabetes” and “Hypertension” and “aged” and “Pharmaceutical Services”. A intervenção farmacêutica tem influência positiva diante aos cuidados geriátricos, visto que é a maioria da sociedade e está exposta a diversos tipos de medicamentos. E como os serviços farmacêuticos podem diminuir a frequência de Reação adversa a medicamento (RAM). O farmacêutico clínico pode e deve ser primordial nas intervenções da terapia medicamentosa e ao aconselhamento adequado ao tratamento. Este estudo contribui cientificamente, pois evidenciou positividade da intervenção farmacêutica no auxílio a pacientes hipertensos e/ou diabéticos, verificando melhoras após a intervenção do farmacêutico.
Analisis Pengaruh Dana Pihak Ketiga, Inflasi, Non Performing Loan Dan Loan To Deposit Ratio Terhadapkredit Modal Kerja Pada Bank Umum Di Jawa Timur
Authors: Qomariyah Venny Atika 
Published: February 2023

Banks are financial institutions that accommodate funds from the public in the form of savings and return them in the form of credit to those in need in order to improve people's lives. Banks also do three other things: collect funds, send money or transfer money, and provide other financial services. Working Capital Credit is a credit facility from a financial institution that is extended to business actors to finance their production and operational activities so that they can expand their business. Through the provision of working capital loans, it is expected to grow the economy. This study shows the results that Third Party Funds have a positive and significant influence on Distribution of Working Capital Loans to Commercial Banks in East Java. Inflation has no positive and insignificant effect on Distribution of Working Capital Loans at Commercial Banks in East Java.Non Performing Loan does not have a positive and insignificant influence on Distribution of Working Capital Loans at Commercial Banks in East Java.Loan to Deposit Ratio has a positive and significant effect on Distribution of Working Capital Loans to Commercial Banks in East Java.

Keywords: Third Party Funds, Inflation, Non Performing Loans, Loan To Deposit Ratio, Working Capital Loans
El diseño técnico pedagógico: Aspectos conceptuales y metodológicos
Authors: Rodríguez de los Ríos Luis Alberto , Flores Limo Fernando Antonio , Landa Maturrano Bertha Aurora , Rubio González Jorge Luis 
Published: February 2023

Se presenta un análisis de las bases teórico–conceptuales y metodológicas del diseño tecnopedagógico, considerando su omnipresencia en el contexto de la modalidad educativa no presencial, remota y virtual en condiciones de la pandemia global causada por el COVID-19, en condiciones de excepcionalidad y perspectivas de sostenibilidad. Los autores estamos convencidos de la fecundidad y urgente aplicabilidad del diseño tecnopedagógico en el escenario educativo actual, signado por la virtualidad con el soporte transformador de las herramientas digitales disponibles. En este artículo mencionamos algunas teorías, las que se pueden referenciar para tomar decisiones sobre el diseño del proceso enseñanza-aprendizaje; así como algunas aplicaciones reportadas en los últimos años.
Observation of electronic spectra modulation in a CH3NH3PbBr3 crystal by utilizing transient absorption microscopy
Authors: Katayama Tetsuro , Fujita Yuma , Akagi Yuichiro , Wang Kangpeng , Dahan Raphael , Fishman Tal , Kaminer Ido , Koinkar Pankaj , Furube Akihiro 
Published: February 2023

Abstract
Organic–inorganic lead halide perovskite materials have attractive properties not only for solar cells but also for LED because of their high performance and wavelength tunability. Such an efficient light-emitting and lasing nature are indispensable for their applications, and the essential needs are miniaturization and low lasing threshold. One material that satisfies these requirements is lead halide perovskite. To understand the time evolution of the interaction between light and matter in a perovskite crystal system, it is necessary to reveal the carrier dynamics in each crystal. In this study, the transient absorption spectra of CH3NH3PbBr3 crystals were measured using a femtosecond transient absorption microscopy. Surprisingly, strong spectra modulation has been observed and these results indicate the charge separation on the surface of the crystal. Amplified spontaneous emission dynamics were also observed in the transient absorption spectra.
Analisis Pesan Dakwah (Dakwah bil Lisan) dalam Pelaksanaan Bimbingan Konseling Sekolah Menengah Atas Kalimantan Timur
Authors: Tahir Muhammad , Wijaya Ida Suryani , Armella Rega 
Published: February 2023

Bimbingan konseling sebagai program yang diselenggarakan di sekolah yang mana berfokus pada pemberian layanan bagi peserta didik mulai dari penanganan berbagai persoalan belajar dan sekolah sampai pada mengembangkan minat dan bakat peserta didik secara maksimal. Dalam proses pelaksanaan layanan bimbingan konseling dibutuhkan beberapa factor penentu keberhasilan program tersebut, salah satunya adalah komunikasi yang dilakukan anatara konseli dan konselor. Tujuan dilaksanakannya penelitian ini adalah untuk mengetahui pesan-pesan dakwah yang terkandung dalam pelaksanaan bimbingan konseling dan Faktor pendukung serta faktor penghambatnya. Penelitian ini menggunakan jenis penelitian kualitatif dengan metode penelitian field research (Penelitian Lapangan). Sumber data utamanya berasal dari hasil wawancara serta observasi guru bimbingan konseling SMA Kalimantan Timur. Teknik pengumpulan data yang digunakan yakni wawancara, observasi dan dokumentasi. Temuan penelitian menunjukan bahwa secara garis besar pelaksanaan layanan bimbingan konseling sekolah menengah atas di Kalimantan Timur memuat pesan dakwah (dakwah bil isan) dengan prinsip antara lain, menggunakan perkataan yang baik dan benar (Qaulan Sadidan dan Qaulan Ma‟rufa), perkataan yang komunikatif (Qaulan Balighan), perkataan yang ringan (Qaulan Masyura‟), berkata lemah lembut (Qaulan Layyina), dan perkataan yang mulia (Qaulan Karima). Disisi lain, hal yang mencakup dalam pengukuran keberhasilan atas pelaksanaan bimbingan konseling sekolah menengah atas di Kalimantan Timur yakni, faktor pendukung dan penghambat. Diantara faktor pendukung yang dimaksud meliputi sumber daya manusia yang memadai dan kompeten, sarana dan prasarana dapat mendukung pelaksanaan layanan bimbingan konseling sepenuhnya, bentuk kerja sama orang tua dan pihak sekolah, serta adanya supervisi secara berkala. Adapun faktor penghambat antara lain; keterbatasan sumber daya manusia dan sarana prasarana, kurangnya kerja sama orang tua kepada pihak sekolah, dan kesenjangan pengetahuan dan latar belakang dari peserta didik.
Pengaruh Faktor Eksternal Terhadap Kredit Bermasalah Serta Kinerja Keuangan Pada Bank BPD Tahun 2014-2018
Authors: Resmawan Haris 
Published: February 2023

Penelitian ini bertujuan mengetahui dan memperoleh hasil analisis mengenai faktor eksternal dan mengetahui pengaruhnya terhadap kredit bermasalah serta implikasinya terhadap kinerja keuangan pada Bank BPD. Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan menggunakan pendekatan kuantitatif. Sampel dalam penelitian ini yaitu Bank Pembangunan Daerah periode 2014 sampai dengan 2018 yang dipilih dengan metode purposive sampling dengan kriteria laporan keuangan bank BPD yang telah diaudit dan terjadi beberapa fenomena yang dapat memberikan gambaran terbaru mengenai NPL dan kinerja keuangan. Data dianalisis dengan menggunakan teknik analisis data panel. Secara umum penelitian ini menyimpulkan bahwa 1) terdapat pengaruh tingkat suku bunga terhadap kredit bermasalah dengan arah pengaruh yang positif, 2) terdapat pengaruh kurs terhadap kredit bermasalah dengan arah hubungan yang negatif, 3) terdapat pengaruh Gross Domestic Product terhadap kredit bermasalah dengan arah pengaruh yang positif, serta 4) terdapat pengaruh kredit bermasalah terhadap Return on Assets dengan arah hubungan yang negatif.
Folicolous Fungi of Medicinal Plants in North Western Tarai region of Uttar Pradesh
Authors: Singh D. P. , Mall T. P. 
Published: February 2023

The North Western Tarai be lt of U.P. is next only to Eastern & Western ghats as on e of the hot spots of Biodiversity in general and the diversity of fungal organisms inhabiting plant leaves in particular. Keeping the above view in mind a survey trip was organized for Bhinga forest range, Shrawasti on Oct 29, 2006 and Dudwa Tiger Reserve , Kh eri Lakh impu r on Nov 23 and 24, 2006 for col lection and docu mentation about eth nomedi cinal plan ts as well as Fol icolous fun gi in fecti ng the medi cinal plants. During the su rvey more than fifty five ethnomedicinal plants were collected. Out of these plants about 25 plants species represented by 20 Genera of sixteen families have been found infected with sixteen different fungal species. Cercospora sp. and Stenella sp. are recorded to infected four plants each. Cercospora was recorded on Cassia fistula, Momordica sp., Clerodendron and Lagerstraemia where as Stenella sp. was recorded on Celastrus paniculatus, Litisea grutinosa, Teliocora acuminata, Ficus sacra. Phoma sp. was found on Glycosmis pentaphylla, Teliocora sp. and Mallotus philipinsis. Zygosporium was recorded on Mallotus philipinsis and Sterculia balen Remaining fungus were recorded only on single host viz. Leptozyphium on Diosphros; Stenella cassiae on Cassia fistula; Alternaria sp. on Ichnocarpus frutiscens; Sirosporium on Carica carandas; Passalora sp. on Calotropis procera; uredial stage of rust on Tectona grandis; Pseudocercospora on Ziziphus; Meliola sp. on Mallotus philipinsis; Acremonium zonatum on Teliocora sp; Fuligomyces on Litisea chinensis; Cladosporium on Ficus carica and Cephaloros sp on Justicia sp. Teliocora sp. had been recorded to be infected by three different fungus viz Phoma sp., Stenella sp. and Acremonium zonatum where as Mallotus philippinsis was found infected with Zygosporium, Phoma sp. and Meliola sp.