bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loan Amount versus Monthly Payments: The Effect of Loan Application Formats on Consumer Borrowing Decisions
Authors: Johnson Alicia M , Villanova Daniel , Smith Ronn J 
Published: February 2023

Abstract
Do different loan application formats affect consumer loan requests? Six studies show that when consumers are asked to provide a preferred monthly payment (MP) (vs. loan amount [LA]), they request different principal amounts. This is because these loan application formats differ in the scale-compatible information they bring to consumers’ mind. When LAs are elicited, consumers think of and request the cost of the expenditure they seek to finance. When MPs are elicited, however, consumers think of their monthly budget slack to construct and then request MPs they perceive to be affordable. For lower cost loans with a given term and interest rate, the MP (vs. LA) format results in larger principal requests. This effect reverses for higher cost acquisitions because individuals’ budget slack caps out around $500 per month. These studies provide insight into how consumer loan application formats can affect consumer borrowing, as well as the psychological underpinnings responsible for the effect. Theoretical, managerial, and consumer welfare implications of the findings are discussed.
Degradation of helicase-like transcription factor (HLTF) by β-TrCP promotes hepatocarcinogenesis via activation of the p62/mTOR axis
Authors: Tan Ye , Wu Di , Liu Ze-Yu , Yu Hong-Qiang , Zheng Xiang-Ru , Lin Xiao-Tong , Bie Ping , Zhang Lei-Da , Xie Chuan-Ming 
Published: February 2023

Abstract
Helicase-like transcription factor (HLTF) has been found to be involved in the maintenance of genome stability and tumour suppression, but whether its downregulation in cancers is associated with posttranslational regulation remains unclear. Here, we observed that HLTF was significantly downregulated in hepatocellular carcinoma (HCC) tissues and positively associated with the survival of HCC patients. Mechanistically, the decreased expression of HLTF in HCC was attributed to elevated β-TrCP-mediated ubiquitination and degradation. Knockdown of HLTF enhanced p62 transcriptional activity and mammalian target of rapamycin (mTOR) activation, leading to HCC tumourigenesis. Inhibition of mTOR effectively blocked β-TrCP overexpression- or HLTF knockdown-mediated HCC tumourigenesis and metastasis. Furthermore, in clinical tissues, decreased HLTF expression was positively correlated with elevated expression of β-TrCP, p62, or p-mTOR in HCC patients. Overall, our data not only uncover new roles of HLTF in HCC cell proliferation and metastasis, but also reveal a novel posttranslational modification of HLTF by β-TrCP, indicating that the β-TrCP/HLTF/p62/mTOR axis may be a new oncogenic driver involved in HCC development. This finding provides a potential therapeutic strategy for HCC patients by targeting the β-TrCP/HLTF/p62/mTOR axis.
Double vision approach applied by two teams for retrosternal gastric conduit for gastric tube cancer
Authors: Machino Ryusuke , Kobayashi Shinichiro , Tagawa Tsutomu , Taniguchi Ken , Kanetaka Kengo , Eguchi Susumu , Nagayasu Takeshi 
Published: February 2023

AbstractGastric tube cancer is classically treated with resection through a midline sternal incision. However, because of its invasiveness and limited reconstructive potential, transdiaphragmatic laparoscopic or thoracoscopic dissection of the gastric tube has been investigated. As resection from only the abdominal or thoracic cavity is difficult, we performed surgery with a thoracic surgeon approaching from the thoracic cavity and an abdominal surgeon simultaneously approaching from the cervical and abdominal regions. The gastric tube may be tightly adhered to the back of the sternum, cervicothoracic transition or thoracoabdominal transition. Dissection can be safely performed by operating from two directions simultaneously, the neck and chest or chest and abdomen, to successfully withdraw the gastric tube from the abdominal cavity. We performed this surgery in four cases. This collaborative operation provided a good surgical view and allowed for safe dissection of the gastric tube without requiring sternotomy.
Ossification of ligamentum flavum related to progressive thoracic myelopathy and acute paraplegia in a Central-European male with a thoracic kyphoscoliosis
Authors: Erdani Danijel , Topolovec Matevž , Hero Nikša , Brumat Peter 
Published: February 2023

AbstractThe ossification of the ligamentum flavum (OLF) presents a significant risk factor in the development of spinal cord compression in the (lower) thoracic spine, particularly in eastern Asian elderly males. The definite causes for OLF have not yet been fully uncovered, whereby age, genetics, metabolic disorders and mechanical stress are deemed among the most plausible pathophysiological factors in OLF. Spinal deformities (mostly kyphotic) are associated with an excess in tensile forces, which may lead to hypertrophy and OLF. This unique case of OLF-related acute paraplegia and progressive thoracic myelopathy in a Central-European male patient may indicate the role of a (kyphoscoliotic) spinal deformity in the initiation and progression of the OLF-related (thoracic) myelopathy. Promptly initiated surgical decompression and (partial) deformity correction may, along with proper subsequent intradisciplinary rehabilitation process, greatly improve the clinical outcome post-treatment, especially in terms of quality of life and residual pain.
Spontaneous periduodenal hematoma: a rare surgical and radiological conundrum
Authors: Padar Maria , Rieseberg Amie , Hendahewa Rasika 
Published: February 2023

AbstractThis is a case of a 68-year-old female with spontaneous and rare periduodenal hematoma of unknown origin without any signs or symptoms of duodenal stenosis. All causes of known precipitating factors, such as trauma, intervention, anticoagulation, pancreatitis or malignant processes, were ruled out. She was managed conservatively, with a series of radiological investigations performed throughout her 7-day admission to further define stability and investigate the possible cause for the periduodenal hemorrhage. A repeat magnetic resonance imaging 4 weeks later showed near resolution of the hematoma. The underlying cause in this case remains unclear.
Discovery of optical emission associated with the supernova remnant G107.5−1.5
Authors: Bakış H , Bulut G , Bakış V , Sano H , Sezer A 
Published: February 2023

ABSTRACT
We present the first results from an imaging and a spectroscopic survey of the optical emission associated with supernova remnant (SNR) G107.5−1.5. We discovered optical diffuse and filamentary emission from G107.5−1.5 using the 1.5- and 1-m telescopes. The optical emissions from the North-East (NE) and North-West (NW) regions show the diffuse structure, while the South-East (SE) and East (E) regions show filamentary structure. From long-slit spectra, we found [S ii]/H α &gt; 0.5 for the SE and E regions, which supports the origin of the emission being from shock-heated gas. The average [S ii]/H α ratio is found to be ∼0.4 and ∼0.3 for the NW and NE regions, respectively, indicating that the optical emission is coming from ionized gas in an H ii region. From the ratios of [S ii]λλ 6716/6731, we estimate an average electron density of ∼2400 cm−3 for the NW region, which can be attributed to the dense ionized gas. The average [S ii]λλ 6716/6731 ratios are ∼1.25 and ∼1.15 for the SE and E regions, respectively, which are indicative of low-electron density.
Varying alpha, blinding, and bias in existing measurements
Authors: Lee Chung-Chi , Webb John K , Carswell Robert F , Dzuba Vladimir A , Flambaum Victor V , Milaković Dinko 
Published: February 2023

ABSTRACT
The high resolution spectrograph ESPRESSO on the VLT allows measurements of fundamental constants at unprecedented precision and hence enables tests for space–time variations predicted by some theories. In a series of recent papers, we developed optimal analysis procedures that expose and eliminate the subjectivity and bias in previous quasar absorption system measurements. In this paper, we analyse the ESPRESSO spectrum of the absorption system at zabs = 1.15 towards the quasar HE 0515-4414. Our goal here is not to provide a new unbiased measurement of Δα/α in this system (that will be done separately). Rather, it is to carefully examine the impact of blinding procedures applied in many previous measurements of the fine structure constant in quasar absorption systems. To do this, we emulate previous procedures, using supercomputer Monte Carlo AI calculations to generate a large number of independently constructed models of the absorption complex. Each model is obtained using ai-vpfit, with Δα/α fixed until a ‘final’ model for the absorption system is obtained, at which point Δα/α is then released as a free parameter for one final optimization. The results show that the value of Δα/α obtained in this way is systematically biased towards the initially fixed value i.e. this process produces measurements that are unrelated to the true value of Δα/α. The implication is straightforward: to avoid bias, all future measurements must include Δα/α as a free parameter from the beginning of the modelling process.
3D radiative transfer kilonova modelling for binary neutron star merger simulations
Authors: Collins Christine E , Bauswein Andreas , Sim Stuart A , Vijayan Vimal , Martínez-Pinedo Gabriel , Just Oliver , Shingles Luke J , Kromer Markus 
Published: February 2023

ABSTRACTThe detection of GW170817 and the accompanying electromagnetic counterpart, AT2017gfo, have provided an important set of observational constraints for theoretical models of neutron star mergers, nucleosynthesis, and radiative transfer for kilonovae. We apply the three-dimensional (3D) Monte Carlo radiative transfer code artis to produce synthetic light curves of the dynamical ejecta from a neutron star merger, which has been modelled with 3D smooth particle hydrodynamics and included neutrino interactions. Nucleosynthesis calculations provide the energy released from radioactive decays of r-process nuclei, and radiation transport is performed using grey opacities given as functions of the electron fraction. We present line-of-sight-dependent bolometric light curves, and find the emission along polar lines of sight to be up to a factor of ∼2 brighter than that along equatorial lines of sight. Instead of a distinct emission peak, our bolometric light curve exhibits a monotonic decline, characterized by a shoulder at the time when the bulk ejecta becomes optically thin. We show approximate band light curves based on radiation temperatures and compare these to the observations of AT2017gfo. We find that the rapidly declining temperatures lead to a blue to red colour evolution similar to that shown by AT2017gfo. We also investigate the impact of an additional, spherically symmetric secular ejecta component, and we find that the early light curve remains nearly unaffected, while after about $1\,$ d the emission is strongly enhanced and dominated by the secular ejecta, leading to the shift of the shoulder from ∼1–2 to 6–10 d.
Excess Mortality Associated With Loiasis: Confirmation by a New Retrospective Cohort Study Conducted in the Republic of Congo
Authors: Hemilembolo Marlhand C , Niama Ange Clauvel , Campillo Jérémy T , Pion Sébastien D , Missamou François , Whittaker Charles , Kankou Jean-Médard , Ndziessi Gilbert , Bileckot Richard R , Boussinesq Michel , Chesnais Cédric B 
Published: February 2023

AbstractBackgroundLoiasis (Loa loa filariasis) is considered a benign disease and is currently not included in the World Health Organization’s (WHO's) list of Neglected Tropical Diseases, despite mounting evidence suggesting significant disease burden in endemic areas. We conducted a retrospective cohort study to assess the mortality associated with L. loa microfilaremia in the Southwestern Republic of Congo.MethodsThe cohort included 3329 individuals from 53 villages screened for loiasis in 2004. We compared mortality rates in 2021 for individuals initially diagnosed as with or without L. loa microfilariae 17 years earlier. Data were analyzed at the community level to calculate crude mortality rates. Survival models were used to estimate the effect of L. loa microfilaremia on mortality in the population.ResultsAt baseline, prevalence of microfilaremia was 16.2%. During 17.62 years of cohort follow-up, 751 deaths were recorded, representing a crude mortality rate of 15.36 (95% CI, 14.28–16.50) per 1000 person-years. Median survival time was 58.5 (95% CI, 49.7–67.3) years and 39.2 (95% CI, 32.6–45.8) years for amicrofilaremic and microfilaremic indiviudals, respectively.ConclusionsA significant reduction in life expectancy was associated with L. loa microfilaremia, confirming previous observations from Cameroon. This adds to the evidence that loiasis is not a benign disease and deserves to be included in the WHO's list of Neglected Tropical Diseases.
PP2C.D phosphatase SAL1 positively regulates aluminum resistance via restriction of aluminum uptake in rice
Authors: Xie Wenxiang , Liu Shuo , Gao Huiling , Wu Jun , Liu Dilin , Kinoshita Toshinori , Huang Chao-Feng 
Published: February 2023

AbstractAluminum (Al) toxicity represents a primary constraint for crop production in acidic soils. Rice (Oryza sativa) is a highly Al-resistant species; however, the molecular mechanisms underlying its high Al resistance are still not fully understood. Here, we identified SAL1 (SENSITIVE TO ALUMINUM 1), which encodes a plasma membrane (PM)-localized PP2C.D phosphatase, as a crucial regulator of Al resistance using a forward genetic screen. SAL1 was found to interact with and inhibit the activity of PM H+-ATPases, and mutation of SAL1 increased PM H+-ATPase activity and Al uptake, causing hypersensitivity to internal Al toxicity. Furthermore, knockout of NRAT1 (NRAMP ALUMINUM TRANSPORTER 1) encoding an Al uptake transporter in a sal1 background rescued the Al-sensitive phenotype of sal1, revealing that coordination of Al accumulation in the cell, wall and symplasm is critical for Al resistance in rice. By contrast, we found that mutations of PP2C.D phosphatase-encoding genes in Arabidopsis (Arabidopsis thaliana) enhanced Al resistance, which was attributed to increased malate secretion. Our results reveal the importance of PP2C.D phosphatases in Al resistance and the different strategies used by rice and Arabidopsis to defend against Al toxicity.
Are Executives in Short Supply? Evidence from Death Events
Authors: Sauvagnat Julien , Schivardi Fabiano 
Published: February 2023

Abstract
Using exhaustive administrative data on Italian social security records, we construct measures of local labour market thickness for executives that vary by industry and location. We show that firm performance is strongly and persistently affected by executive death, but only in thin local labour markets. The new executives hired after death events in thin local labour markets have lower education levels and are more likely to be replaced. These predictions are consistent with a simple model of executive search in which market thickness determines the arrival rate of applications for executive positions.
Joining Forces: The Spillover Effects of EPA Enforcement Actions and the Role of Socially Responsible Investors
Authors: Dasgupta Sudipto , Huynh Thanh D , Xia Ying 
Published: February 2023

Abstract
We find that firms reduce toxic emissions at their local plants following EPA enforcement actions against nearby plants operated by peer firms that compete in the same product market. These reductions are more pronounced for plants located near socially responsible mutual funds (SRMFs) that hold these plants’ parent firms’ shares. Close proximity to SRMFs is associated with real investment in abatement measures to mitigate emissions. While plants increase emissions again in the long run, such reversals do not occur in plants located near SRMFs. Taken together, our results suggest that local SRMFs complement EPA enforcement in influencing plants’ emissions.
Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Characteristics of patients initiating treatment with baricitinib and outcomes at follow-up: analysis of BSRBR-RA Registry data
Authors: Edwards Christopher J , Mount Julie , Meeks Alexandra , Gulati Tania , Zaremba-Pechmann Liliana , Sheesh Mohamed , Larsson Esbjörn , Dennison Elaine 
Published: February 2023

Abstract

Objectives
To describe selected baseline characteristics, continuation with baricitinib and disease activity over time in patients initiating treatment with baricitinib in a UK real-world rheumatology setting.

Methods
Baseline and follow-up data were analysed from baricitinib-treated patients newly recruited to the British Society for Rheumatology Biologics Registry–RA (BSRBR-RA) baricitinib cohort between 1 January 2018 and 31 March 2020. The primary objective was to evaluate continuation of baricitinib treatment in patients with at least one follow-up. Analyses were performed using the full baricitinib cohort, overall and by patient subgroup: biologic DMARD (bDMARD)/targeted synthetic (ts)DMARD-naive vs -experienced, baricitinib 4 vs 2 mg, age ≥65 vs &lt;65 years, monotherapy vs combination therapy and male vs female.

Results
At baseline, the study cohort (n = 561) was 76.5% female, mean age 60.0 years, had longstanding (mean 13.1 years) and severe RA, and 54.0% had previously received a bDMARD/tsDMARD. Of 265 and 110 patients completing the 6- and 12-month follow-ups with available data, 77.7 and 69.1% remained on baricitinib at each time, respectively. In all Kaplan–Meier analyses, &gt;60% of patients remained on baricitinib at 540 days. Continuation of baricitinib therapy differed between some subgroup pairs (bDMARD/tsDMARD naive/experienced, baricitinib 2 mg/4 mg). Disease activity was lower at both follow-ups than at baseline, overall and in all subgroups.

Conclusion
In the early years of real-world baricitinib use in the UK, a high proportion of patients continued with treatment at both 6 and 12 months, at which times disease activity was lower than at baseline.
Population-representative study reveals cardiovascular and metabolic disease biomarkers associated with misaligned sleep schedules
Authors: Sládek Martin , Klusáček Jan , Hamplová Dana , Sumová Alena 
Published: February 2023

Abstract

Study Objectives
Social jetlag manifests as a difference in sleep timing on workdays and free days. Social jetlag is often associated with shorter, lower-quality sleep, so it is unclear how much the chronic circadian misalignment contributes to observed negative health outcomes. We aimed to (1) investigate associations between social jetlag, chronotype (one of its determinants), and the levels of health markers, (2) describe factors associated with social jetlag, and (3) examine whether working from home can reduce social jetlag.

Methods
Adult respondents participated in a nationally representative longitudinal survey of Czech households (individuals in each wave: n2018/19/20 = 5132/1957/1533), which included Munich ChronoType Questionnaire to evaluate chronotype and social jetlag. A subset provided blood samples (n2019 = 1957) for detection of nine biomarkers and was surveyed in three successive years (social jetlag calculated for n2018/19/20 = 3930/1601/1237). Data were analyzed by nonparametric univariate tests and mixed effects multivariate regression with social jetlag, chronotype, sex, age, body-mass index, and reported diseases as predictors and biomarker levels as outcomes.

Results
Higher social jetlag (≥0.65 h) was significantly associated with increased levels of total cholesterol and low-density lipoprotein cholesterol, particularly in participants older than 50 years (Mann–Whitney, men: pCHL = 0.0005, pLDL = 0.0009; women: pCHL = 0.0079, pLDL = 0.0068). Extreme chronotypes were associated with cardiovascular disease risk markers regardless of social jetlag (Kruskal–Wallis, p &lt; 0.0001). Commuting to work and time stress were identified as important contributors to social jetlag. Individual longitudinal data showed that working from home decreased social jetlag and prolonged sleep.

Conclusions
We report significant associations between sleep phase preference, social jetlag, and cardio-metabolic biomarkers.
ASCs Activate cGAS-Type I IFNs-IL-7 Axis Via Pseudomonas aeruginosa-Derived Outer Membrane Vesicles to Resolve Pneumonia
Authors: Di Caixia , Jiang Yanshan , Li Lulu , Shi Mengmeng , Zhu Yinggang , Zhang Jing , Song Yuanlin , Su Xiao , Qu Jieming 
Published: February 2023

Abstract
Mesenchymal stem cells (MSCs) therapy could efficiently attenuate LPS-induced acute lung injury and Pseudomonas aeruginosa (PA)-induced acute pneumonia. However, the underlying molecular mechanisms are still elusive. Here, we report that PA-derived outer membrane vesicles (OMVs) trigger mouse primary adipose tissue-derived mesenchymal stem cells (ASCs) to upregulate cyclic GMP-AMP synthase (cGAS) for sensing of double-stranded DNA (dsDNA) and the expression of interleukin (IL)-7. Loss of cGAS-interferon (IFN)-β axis abolished the protective function of ASCs to PA-induced acute pneumonia in mice. Mechanistically, OMVs-delivered PA dsDNA primes cGAS-stimulator of interferon genes (STING) signaling pathway and increases the IL-7 production in ASCs via IFN-β signaling. Meanwhile, dsDNA-primed ASCs furthermore amplifies IL-7 expression in primary lung epithelial cells and mouse lung epithelial (MLE)-12 cell line via increased IFN-β. Our findings thus implicate a molecular mechanism that ASCs recognize PA-OMVs-derived dsDNA to secrete IL-7 via activating cGAS, suggesting a potential therapeutic strategy of ASCs transfer for PA-induced lung infection and inflammation.
The Labor-Supply Consequences of Having a Child in China
Authors: Wang Shing-Yi 
Published: February 2023

AbstractCombining eight years of panel data with an event study approach, this study shows that rural Chinese women’s labor supply falls following the birth of a child. In contrast, men’s labor supply does not fall after birth. Furthermore, a woman’s labor supply falls more following the birth of a son than a daughter. Following the birth of a son relative to a daughter, household cigarette consumption declines, and a mother’s leisure time, her probability of school enrollment, and her participation in decision-making increase. There are no increases in other investments in boys complementary to mothers’ time, such as food expenditures, breastfeeding, or immunizations. These results are consistent with the idea that mothers are rewarded more for having a son, leading them to have more leisure and work less.