bluuebunny/crossref_metadata_2025_split huggingface dataset:
ADVANTAGES OF BUSINESS GAME METHOD IN TEACHING DISCIPLINE "INFECTIOUS DISEASES" TO FUTURE DENTAL DOCTORS
Authors: Marchenko O.H. , Marchenko K.V. , Vatsenko A.I. , Poltorapavlov V.A. , Zdor O.I. 
Published: March 2023

Dentistry as a specialty belongs to the professions carrying a high occupational risk of exposure to several pathogens due to the special features of dental treatment. Knowing the clinical course of these diseases can significantly contribute to the diagnostic process and facilitate the timely detection of the disease thus, reducing the risk of transmission in the dental chair. At the present stage, the training of future dentists requires the incorporation of innovative teaching methods aimed at developing students' creative and critical thinking that can be achieved by the business game method. Therefore, the purpose of the article is to improve the professional competencies of dental students by introducing the business game method in the study of the discipline "Infectious Diseases". The article presents modern approaches to teaching the discipline to future dentists in order to build up and strengthen professional competencies and practical skills in working with patients. The use of a business game allows each student to work out an algorithm of actions in accordance with the chosen clinical situation, to identify errors in working with a patient or using dental instruments that is critically important in preventing the spread of hospital-acquired infections and contributes to the formation of professional skills of a future dentist. The introduction of this teaching method is aimed at improving the quality of dental students' knowledge of the clinical picture of infectious diseases; it will help in the formation of medical alertness for the diagnosis of infectious diseases by mucosal lesions, ways to implement the epidemic process in the dental chair, infection control and measures for the specific prevention of infectious diseases. Thus, the active involvement of students in the educational business game makes it possible to improve the professional competencies of future dental doctors that is essential in their professional activity.
STUDENT OLYMPIAD AS AN INTERACTIVE METHOD OF IMPROVING THE QUALITY OF STUDENT TRAINING AT THE DEPARTMENT OF HISTOLOGY, CYTOLOGY AND EMBRYOLOGY
Authors: Shepitko V.I. , Boruta N.V. , Lysachenko O.D. , Rud M.V. , Levchenko O.A. 
Published: March 2023

The article deals with the methods of organizing student competitions, a form of extracurricular work, arranged by the Department of Histology, Cytology and Embryology of Poltava State Medical University. Student Olympiad is a type of scientific event for students; according to its structure, the Olympiad, as a scientific event at a university, can be subject or thematic. Both types are creative competitions for students. The Olympiad is held to test students' theoretical knowledge of a particular discipline and is aimed at solving certain practical problems. The first years of studying at any university are considered to be the most difficult for both students and teachers due to adaptation processes to new disciplines and learning conditions. The Student Olympiads are a universal means of developing students' creative abilities, intensifying their educational and cognitive activities and improving the quality of training, intensifying and improving the educational process. Not only are the All-Ukrainian Student Olympiads competitions, but they also include a cultural and educational program. The sequence of activities and tasks corresponds to the stages of group development: 1) acquaintance (self-presentation of the participating teams); 2) productive activity (interaction within three rounds of the Olympiad); and 3) comprehension of the experience gained, farewell (summarizing the results of the Olympiad, sharing impressions, providing feedback, exchanging contact information).
Discussion of the organization of the student Olympiad at the Department of Histology, Cytology and Embryology of Poltava State Medical University helps to motivate students and increase their interest in the discipline, improve and enhance their knowledge of the subject. The Olympiad is a universal means of students' creativity development, educational and cognitive activity activation, specialist training and educational process improvement.
RETRACTED: Study on the design of composite beams under complex environment in mountainous areas
Authors: Zhao Yicheng , Sun Caizhi , Li Sheng 
Published: March 2023

The mountain area is faced with complex conditions such as vertical and horizontal valleys, complex geological topography, many earthquake fault zones, high seismic intensity, fragile ecology, and changeable climate. The traditional concrete bridges have a heavy weight, high consumption of sand and gravel materials, large structural dimensions of steel box composite bridges, high steel consumption, and poor overall horizontal performance of steel plate composite beams, which are not suitable for mountain construction conditions. Therefore, based on the construction environment and application requirements of highway bridges in mountainous areas, the structural scheme of steel box-steel plate composite beam is put forward in this paper, and the design of a 25 m–50 m standard-span steel box-steel plate composite beam is studied. The results show that the steel box-steel plate composite beam structure scheme is adopted, which has excellent mechanical characteristics of steel box girder and simple structure of steel plate girder. It has the mechanical characteristics of “balanced transverse force and excellent longitudinal force”, so it is a reasonable choice for small radius curved beam bridge in a mountainous area, so it is a reasonable choice for small radius curved beam bridge in a mountainous area. The steel box-steel plate composite beam adopts the integrated technology of manufacture, transportation and installation, which can better meet the road transport conditions in the mountain area. The longitudinal assembly of the manufacturing unit as the installation unit can ensure the rapid and high-precision installation of the construction site, and the assembly construction of the bridge in the mountain area has been realized. The technical and economic comparison shows that the mechanical performance of steel box-steel plate composite beam is similar to that of steel box beam and obviously better than that of steel plate girder. The steel consumption and construction period of steel box-steel plate composite beam are similar to that of steel plate girder, and are significantly less than that of the steel box girder. Therefore, the steel box-steel plate composite beam is a good choice for mountain bridge construction.
The ABCG2 rs2231142 polymorphism and the risk of nephrolithiasis: A case–control study from the Taiwan biobank
Authors: Lin Ching-Tsai , Chen I-Chieh , Chen Yen-Ju , Lin Ying-Cheng , Chang Jui-Chun , Wang Tsai-Jung , Huang Wen-Nan , Chen Yi-Hsing , Chen Yi-Huei , Lin Ching-Heng , Chen Yi-Ming 
Published: March 2023

BackgroundHyperuricemia and gout are risk factors of nephrolithiasis. However, it is unclear whether the ABCG2 gene contributes to the development of nephrolithiasis. We aimed to investigate the interaction between the ABCG2 rs2231142 variant and incident nephrolithiasis in the Taiwanese population.MethodsA total of 120,267 adults aged 30–70 years were enrolled from the Taiwan Biobank data-base in this retrospective case–control study and genotyped for rs2231142. The primary outcome was the prevalence of self-reported nephrolithiasis. The odds ratio (OR) of incident nephrolithiasis was analyzed by multivariable logistic regression models with adjustment for multifactorial confounding factors. Associations of the ABCG2 rs2231142 variant with serum uric acid levels, and the incident nephrolithiasis were explored.ResultsThe frequency of rs2231142 T allele was 53%, and 8,410 participants had nephrolithiasis. The multivariable-adjusted OR (95% confidence interval) of nephrolithiasis was 1.18 (1.09–1.28) and 1.12 (1.06–1.18) for TT and GT genotypes, respectively, compared with the GG genotype (p&lt;0.001), specifically in the male population with hyperuricemia. Higher age, male sex, hyperlipidemia, hypertension, diabetes mellitus, hyperuricemia, smoking and overweight were independent risk factors for nephrolithiasis. In contrast, regular physical exercise is a protective factor against nephrolithiasis.ConclusionsABCG2 genetic variation is a significant risk of nephrolithiasis, independent of serum uric acid levels. For rs2231142 T allele carriers, our result provides evidence for precision healthcare to tackle hyperuricemia, comorbidities, smoking, and overweight, and recommend regular physical exercise for the prevention of nephrolithiasis.
The impacts of bronze age in the gene pool of Chinese: Insights from phylogeographics of Y-chromosomal haplogroup N1a2a-F1101
Authors: Yu Hui-Xin , Ao Cheliger , Wang Xiao-Peng , Zhang Xian-Peng , Sun Jin , Li Hui , Liu Kai-Jun , Wei Lan-Hai 
Published: March 2023

Objectives: Previous studies of archaeology and history suggested that the rise and prosperity of Bronze Age culture in East Asia had made essential contribution to the formation of early state and civilization in this region. However, the impacts in perspective of genetics remain ambiguous. Previous genetic researches indicated the Y-chromosome Q1a1a-M120 and N1a2a-F1101 may be the two most important paternal lineages among the Bronze Age people in ancient northwest China. Here, we investigated the 9,000-years history of haplogroup N1a2a-F1101 with revised phylogenetic tree and spatial autocorrelation analysis.Materials and Methods: In this study, 229 sequences of N1a2a-F1101 were analyzed. We developed a highly-revised phylogenetic tree with age estimates for N1a2a-F1101. In addition, we also explored the geographical distribution of sub-lineages of N1a2a-F1101, and spatial autocorrelation analysis was conducted for each sub-branch.Results: The initial differentiation location of N1a2a-F1101 and its most closely related branch, N1a2b-P43, a major lineage of Uralic-speaking populations in northern Eurasia, is likely the west part of northeast China. After ~4 thousand years of bottleneck effect period, haplgroup N1a2a-F1101 experienced continuous expansion during the Chalcolithic age (~ 4.5 kya to 4 kya) and Bronze age (~ 4 kya to 2.5 kya) in northern China. Ancient DNA evidence supported that this haplogroup is the lineage of ruling family of Zhou Dynasty (~ 3 kya-2.2 kya) of ancient China.Discussion: In general, we proposed that the Bronze Age people in the border area between the eastern Eurasian steppe and northern China not only played a key role in promoting the early state and civilization of China, but also left significant traces in the gene pool of Chinese people.
Fatty acid transport protein inhibition sensitizes breast and ovarian cancers to oncolytic virus therapy via lipid modulation of the tumor microenvironment
Authors: Surendran Abera , Jamalkhah Monire , Poutou Joanna , Birtch Rayanna , Lawson Christine , Dave Jaahnavi , Crupi Mathieu J. F. , Mayer Justin , Taylor Victoria , Petryk Julia , de Souza Christiano Tanese , Moodie Neil , Billingsley Jacob Lecompte , Austin Bradley , Cormack Nicole , Blamey Natalie , Rezaei Reza , McCloskey Curtis W. , Fekete Emily E. F. , Birdi Harsimrat K. , Neault Serge , Jamieson Taylor R. , Wylie Brenna , Tucker Sarah , Azad Taha , Vanderhyden Barbara , Tai Lee-Hwa , Bell John C. , Ilkow Carolina S. 
Published: March 2023

IntroductionAdipocytes in the tumour microenvironment are highly dynamic cells that have an established role in tumour progression, but their impact on anti-cancer therapy resistance is becoming increasingly difficult to overlook.MethodsWe investigated the role of adipose tissue and adipocytes in response to oncolytic virus (OV) therapy in adipose-rich tumours such as breast and ovarian neoplasms.ResultsWe show that secreted products in adipocyte-conditioned medium significantly impairs productive virus infection and OV-driven cell death. This effect was not due to the direct neutralization of virions or inhibition of OV entry into host cells. Instead, further investigation of adipocyte secreted factors demonstrated that adipocyte-mediated OV resistance is primarily a lipid-driven phenomenon. When lipid moieties are depleted from the adipocyte-conditioned medium, cancer cells are re-sensitized to OV-mediated destruction. We further demonstrated that blocking fatty acid uptake by cancer cells, in a combinatorial strategy with virotherapy, has clinical translational potential to overcome adipocyte-mediated OV resistance.DiscussionOur findings indicate that while adipocyte secreted factors can impede OV infection, the impairment of OV treatment efficacy can be overcome by modulating lipid flux in the tumour milieu.
Genetically predicted levels of folate, vitamin B12, and risk of autoimmune diseases: A Mendelian randomization study
Authors: Yang Hong , Song Jie , Li Aole , Lv Linshuoshuo , Sun Xiaohui , Mao Yingying , Ye Ding 
Published: March 2023

BackgroundEvidence from observational studies on the association of folate and vitamin B12with autoimmune diseases are conflicting.ObjectiveWe aimed to investigate the relationship of folate and vitamin B12with autoimmune diseases using Mendelian randomization (MR).Materials and methodsWe selected single-nucleotide polymorphisms associated with folate and vitamin B12at the genome-wide significance level. Summary-level data for four common autoimmune diseases (vitiligo, inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus) were obtained from large-scale genome-wide association studies, with a sample size of 44,266, 86,640, 58,284, and 23,210, respectively. MR analyses were conducted using the inverse variance weighted (IVW) approach, and sensitivity analyses were further performed to test the robustness.ResultsWe found that a higher genetically determined serum folate level per one standard deviation (SD) was associated with a decreased risk of vitiligo by the IVW method [odds ratios (OR) = 0.47; 95% confidence interval (CI): 0.32–0.69;P= 1.33 × 10-4]. Sensitivity analyses using alternative methods showed similar associations, and no evidence of pleiotropy was detected by MR-Egger regression (P= 0.919). In addition, we observed that vitamin B12per one SD was positively associated with IBD (IVW: OR = 1.14, 95% CI: 1.03–1.26,P= 0.010; maximum likelihood: OR = 1.14, 95% CI: 1.01–1.29,P= 0.035; MR-PRESSO: OR = 1.14, 95% CI:1.01–1.28,P=0.037), while the association was not significant after Bonferroni correction.ConclusionThe study provides convincing evidence for an inverse association between serum folate level and risk of vitiligo. Further studies are warranted to elucidate the possible association between vitamin B12and risk of IBD.
Evaluation of corneal dendritic cell density and subbasal nerve density in contact lens wearers using IVCM: A systematic review and meta-analysis
Authors: Guo Rongjie , Jiang Jiaxuan , Zhang Yanan , Liang Qi , Chen Taige , Hu Kai 
Published: March 2023

PurposeTo evaluate the subclinical changes in corneal dendritic cell density (CDCD) and corneal subbasal nerve density (CSND) in asymptomatic contact lens (CL) wearers.MethodsDatabases including PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials were searched for trials and studies reporting the changes of corneal CDCD and CSND in contact lens wearers published until 25 June 2022. PRISMA guidelines as well as recommended meta-analysis practices were followed. Meta-analysis was conducted using RevMan V.5.3 software.ResultsAfter the screening, 10 studies with 587 eyes of 459 participants were included. Seven studies reported the data of CDCD. Compared with the control group, CDCD in the CL wearers was higher (18.19, 95% CI 18.8–27.57, p = 0.0001). Type of in vivo confocal microscopy (IVCM), wear duration, and frequency of lens change were sources of heterogeneity. The difference in CSND between CL wearers and the control group was insignificant, and subgroup analysis did not reveal a source of heterogeneity.ConclusionOverall, CDCD increased in CL wears, while CSND did not show significant differences. IVCM is a feasible tool to assess subclinical changes in CL wearers.
Classification and prediction of cognitive trajectories of cognitively unimpaired individuals
Authors: Kim Young Ju , Kim Si Eun , Hahn Alice , Jang Hyemin , Kim Jun Pyo , Kim Hee Jin , Na Duk L. , Chin Juhee , Seo Sang Won 
Published: March 2023

ObjectivesEfforts to prevent Alzheimer’s disease (AD) would benefit from identifying cognitively unimpaired (CU) individuals who are liable to progress to cognitive impairment. Therefore, we aimed to develop a model to predict cognitive decline among CU individuals in two independent cohorts.MethodsA total of 407 CU individuals from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and 285 CU individuals from the Samsung Medical Center (SMC) were recruited in this study. We assessed cognitive outcomes by using neuropsychological composite scores in the ADNI and SMC cohorts. We performed latent growth mixture modeling and developed the predictive model.ResultsGrowth mixture modeling identified 13.8 and 13.0% of CU individuals in the ADNI and SMC cohorts, respectively, as the “declining group.” In the ADNI cohort, multivariable logistic regression modeling showed that increased amyloid-β (Aβ) uptake (β [SE]: 4.852 [0.862], p &lt; 0.001), low baseline cognitive composite scores (β [SE]: −0.274 [0.070], p &lt; 0.001), and reduced hippocampal volume (β [SE]: −0.952 [0.302], p = 0.002) were predictive of cognitive decline. In the SMC cohort, increased Aβ uptake (β [SE]: 2.007 [0.549], p &lt; 0.001) and low baseline cognitive composite scores (β [SE]: −4.464 [0.758], p &lt; 0.001) predicted cognitive decline. Finally, predictive models of cognitive decline showed good to excellent discrimination and calibration capabilities (C-statistic = 0.85 for the ADNI model and 0.94 for the SMC model).ConclusionOur study provides novel insights into the cognitive trajectories of CU individuals. Furthermore, the predictive model can facilitate the classification of CU individuals in future primary prevention trials.
Basilar artery plaque distribution is associated with pontine infarction and vertebrobasilar artery geometry
Authors: Zheng Jinmei , Sun Bin , Lin Ruolan , Teng Yongqi , Zheng Enshuang , Zhao Xihai , Xue Yunjing 
Published: March 2023

BackgroundBasilar artery (BA) atherosclerosis is a common cause of posterior-circulation ischemic stroke. In this study, we investigate the relationship between BA plaque distribution and pontine infarction (PI), further, explore the influence of vertebrobasilar artery (VBA) geometries on BA plaque distribution.Materials and methods303 patients were performed with MRI in this study, patients were divided into three groups: no cerebral infarction (NCI), anterior circulation cerebral infarction (ACCI), and posterior circulation cerebral infarction (PCCI), the VBA geometry was classified into four configurations: Walking, Tuning Fork, Lambda, and No Confluence. The AP-Mid-BA, Lateral-Mid-BA, and VA-BA angles were measured on three-dimensional time-of-flight magnetic resonance angiography. Patients underwent high-resolution magnetic resonance imaging to evaluate the BA plaque distribution (either anterior, posterior, or lateral wall). Acute and subacute cerebral infarction [including pontine infarction (PI)] were identified by T2 weighted imaging-fluid-attenuated inversion recovery and diffusion-weighted imaging.ResultsThe presence of BA plaque (P &lt; 0.001) were associated with PCCI. Eighty-six patients all with BA plaque were further analyzed, compared with patients without pontine infarction, patients with pontine infarction were more likely to have plaque distributed at the posterior wall (P = 0.009) and have larger VA-BA anger (38.72° ± 26.01° vs. 26.59° ± 17.33°, P = 0.035). BA plaques in patients with pontine infarction were more frequently located at the posterior wall (50.00%) than at the anterior (10.00%) and lateral (37.50%) walls (P = 0.028). In Walking, Lambda and No Confluence geometry, BA plaques were prone to located at the lateral wall than at the anterior and posterior walls (all P ≤ 0.05). In the Tuning Fork group, BA plaques were evenly distributed.ConclusionBA plaque was related to PCCI, BA plaque distribution was associated with PI, and VBA configuration strongly influences BA plaque distribution.
Frontal midline theta rhythm and gamma activity measured by sheet-type wearable EEG device
Authors: Ueno Keita , Ishii Ryouhei , Ueda Masaya , Yuri Takuma , Shiroma China , Hata Masahiro , Naito Yasuo 
Published: March 2023

IntroductionThe current study measured the frontal midline theta rhythm (Fmθ), which appears in the frontal midline region during the attentional focus state, using the sheet-type wearable electroencephalograph (EEG) device HARU-1, and examined the modulation of frontal gamma band activity by cognitive tasks.MethodsWe measured the frontal EEG of 20 healthy subjects using HARU-1 for 2 min during the rest eyes-closed condition and simple mental calculation task condition, respectively. Statistical analyses were conducted using permutation testing based on t-test and cluster analysis to compare the results between the resting state and the task condition.ResultsTwelve of 20 subjects showed Fmθ during the task condition. The 12 subjects with Fmθ showed significantly higher activity of the theta and gamma bands, and significantly low activity of the alpha band during the task condition compared to the resting condition. In the eight subjects without Fmθ were significantly low activity of the alpha and beta bands and no significant activity in the theta and gamma band activity during the task condition compared to the resting condition.DiscussionThese results indicate that it is possible to measure Fmθ using HARU-1. A novel finding was the gamma band activity appearing with Fmθ in the left and right frontal forehead regions, suggesting that it reflects the function of the prefrontal cortex in working memory tasks.