bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensing echoes: temporal misalignment in auditory brainstem responses as the earliest marker of neurodevelopmental derailment
Authors: Torres Elizabeth B , Varkey Hannah , Vero Joe , London Eric , Phan Ha , Kittler Phyllis , Gordon Anne , Delgado Rafael E , Delgado Christine F , Simpson Elizabeth A 
Published: February 2023

Abstract
Neurodevelopmental disorders are on the rise worldwide, with diagnoses that detect derailment from typical milestones by 3 to 4.5 years of age. By then, the circuitry in the brain has already reached some level of maturation that inevitably takes neurodevelopment through a different course. There is a critical need then to develop analytical methods that detect problems much earlier and identify targets for treatment. We integrate data from multiple sources, including neonatal auditory brainstem responses (ABR), clinical criteria detecting autism years later in those neonates, and similar ABR information for young infants and children who also received a diagnosis of autism spectrum disorders, to produce the earliest known digital screening biomarker to flag neurodevelopmental derailment in neonates. This work also defines concrete targets for treatment and offers a new statistical approach to aid in guiding a personalized course of maturation in line with the highly nonlinear, accelerated neurodevelopmental rates of change in early infancy.
The Lost Capital Asset Pricing Model
Authors: Andrei Daniel , Cujean Julien , Wilson Mungo 
Published: February 2023

Abstract
We provide a novel explanation for the empirical failure of the capital asset pricing model (CAPM) despite its widespread practical use. In a rational-expectations economy in which information is dispersed, variation in expected returns over time and across investors creates an informational gap between investors and the empiricist. The CAPM holds for investors, but the securities market line appears flat to the empiricist. Variation in expected returns across investors accounts for the larger part of this distortion, which is empirically substantial; it offers a new interpretation of why “betting against beta” (BAB) works: BAB really bets on true beta. The empiricist retrieves a stronger CAPM on days when public information reduces disagreement among investors.
JUSTIFICATION OF IMAGING IN DENTAL CLINICS: DOES RADIATION KNOWLEDGE PLAY A ROLE?
Authors: Alashban Yazeed , Alohaly Amani , Shubayr Nasser , Albeshan Salman 
Published: February 2023

AbstractThe study aims to investigate dentists’ knowledge and consideration of radiation in relation to their referral practices and use of referral guidelines for imaging in Saudi Arabia. A cross-sectional study was conducted among dentists in different occupational positions in Saudi Arabia. The analysis showed that 68% of the dentists knew of imaging referral guidelines to consult before ordering an imaging exam. However, more than a quarter of the sample did not use them. More than half of responders estimated the average effective dose correctly for intraoral radiography, 44.8% for panoramic radiography, 53.4% for cone beam dental computed tomography (CT) and 47.8% for a study of dental implants/jaws using CT. Limited radiation knowledge and lack of use of proper referral guidelines among dentists indicate that the imaging referral justification process must be improved. The study concluded that radiation knowledge plays a critical role regarding image justification in dental clinics.
Industry-Specific Profile of COVID-19–Related Workers' Compensation Claims in New York State
Authors: Laskaris Zoey , Markowitz Steven B. 
Published: February 2023

Objective
This study aimed to characterize the distribution and award status of COVID-19–related workers' compensation (WC) claims in New York State (NYS) for 2020 and 2021.

Methods
Characteristics and filing rates of COVID-19 claims were described by industry, time of illness, and award status. Nursing care facilities' claims were compared with the recorded nursing home staff COVID-19 infections and deaths reported by the Centers for Medicare & Medicaid Services (CMS) during the same period.

Results
Of 29,814 COVID-19 claims, 21.9% were awarded benefits, although 86.8% of the claimants worked in essential industries. Of the 46,505 CMS-recorded COVID-19 infections, 1.4% resulted in a claim and 7.2% of the 111 CMS-recorded deaths received death benefits.

Conclusions
The NYS WC program has provided very modest support to essential workers for the likely work-related burden of the pandemic in NYS.
Incidence of stress among emergency nurses: A systematic review and meta-analysis
Authors: Jiaru Jiao , Yanxue Zheng , Wennv Hao 
Published: February 2023

Background:
This study’s main purpose is to evaluate the stress level among emergency nurses systematically.

Methods:
Adhering to the preferred reporting items for systematic reviews and meta-analyses guidelines, nine databases, including PubMed, Cochrane, web of science, Scopus, ScienceDirect, Embase, China National Knowledge Infrastructure, Wanfang, and China biomedical literature service system, were searched to collect cross-sectional studies on emergency nurses. Two researchers independently screened the literature, extracted the data, and evaluated the risk of bias in the included studies.

Results:
From 2655 studies, 21 cross-sectional studies were included, including 4293 subjects. Meta-analysis showed that the incidence of low-level stress was 0.21% (95% CI [0.18–0.24]), the incidence of middle-level stress was 0.46% (95% CI [0.33–0.58]), and the incidence of high-level stress was 0.32% (95% CI [0.22–0.41]), which is mainly at the medium level.

Conclusion:
This review identified the stress level of emergency nurses mainly at the medium level. This result makes nursing administrators pay more attention to the mental health problems of emergency nurses and actively take measures to promote the physical and mental health of emergency nurses and further promote the development of the nursing profession.
Factors associated with hospital choice of Chinese patients: A meta-analysis
Authors: Che Xiaoming , Chen Weidong , Wu Xuehua , Lin Pengcheng 
Published: February 2023

Introduction:
While China continues to optimize the tiered medical care system, the status quo of patients preferring higher-tier hospitals has not improved. Herein, we aimed to analyze the factors influencing patients’ healthcare choices in China and to provide an evidentiary basis for optimizing the tiered healthcare system.

Patient concerns:
Most patients are concerned that primary care services will not provide appropriate treatment or health advice. Also, patients consider medical technology, cost, experience, quality of service and convenience before seeking care.

Outcomes:
A total of 18 cross-sectional studies involving 10,348 samples were included. After combining the effect size, the factors affecting the choice of Chinese patients for medical treatment were medical technology and quality (49%), the convenience of medical treatment (37%), medical expenses (23%), hospital service quality (20%) medical insurance policy (16%), and acquaintance relationship (11%).

Conclusion:
The selection of medical treatment for Chinese residents is primarily influenced by medical technology and convenience. The medical insurance policy does not provide sufficient guidance. Furthermore, the tiered medical care system should be optimized to improve the usability of primary care services.
Diagnostic accuracy of shear wave elastography for endometrial cancer: A meta-analysis
Authors: Bian Jinyi , Li Jingnan , Liu Yangcheng 
Published: February 2023

Background:
This meta-analysis aimed to identify the accuracy of shear wave elastography (SWE) in the diagnosis of endometrial cancer (EC).

Methods:
We searched the PubMed, Cochrane Library, and chinese biomedical literature database from inception to September 30, 2022. Meta-analysis was conducted using STATA version 14.0 and Meta-Disc version 1.4 software. We calculated summary statistics for sensitivity (Sen), specificity (Spe), positive and negative likelihood ratio (LR+/LR−), diagnostic odds ratio (DOR), and receiver operating characteristic (SROC) curves.

Results:
Eight studies that met all the inclusion criteria were included in this meta-analysis. A total of 432 patients with EC and 548 with benign endometrial lesions were assessed. All endometrial lesions were histologically confirmed by SWE. The pooled Sen was 0.91 (95% confidence interval [CI] = 0.83–0.95); the pooled Spe was 0.90 (95% CI = 0.86–0.93); the pooled LR+ was 9.10 (95% CI = 6.20–13.35); the pooled negative LR− was 0.10 (95% CI = 0.05–0.20); the pooled DOR of SWE in the diagnosis of EC was 90.73 (95% CI = 36.62–804.5). The area under the SROC curve was 0.95 (95% CI = 0.93–0.97). No evidence of publication bias was found (t = 0.98, P = .37).

Conclusion:
Our meta-analysis indicates that SWE may have high diagnostic accuracy in the differential diagnosis of benign and malignant endometrial lesions. Thus, SWE may be a useful tool for the diagnosis of EC.
Effects of electrical muscle stimulation on core muscle activation and physical performance in non-athletic adults: A randomized controlled trial
Authors: Yoo Hyun-Joon , Park Sangsoo , Oh Sejun , Kang Munjeong , Seo Yongha , Kim Byung Gon , Lee Sang-Heon 
Published: February 2023

Background:
Electrical muscle stimulation (EMS) activates muscles through electrical currents, resulting in involuntary muscle contractions. This study aimed to evaluate the immediate clinical effects of superimposing EMS on strength training compared with conventional exercise in healthy non-athletic adults.

Methods:
This study was a randomised, controlled, parallel-group trial conducted at a single centre. Forty-one healthy young volunteers were recruited and randomised into two groups: strengthening with superimposed EMS (S+E) and strengthening (S) groups. All participants underwent the 30 minutes of strength training program, three times a week for 8 weeks, consisting of core muscle exercises. Additionally, the S+E group received EMS during training, which stimulated the bilateral abdominal, gluteus, and hip adductor muscles. As the primary outcome measure, we evaluated the changes in muscle thickness, including the abdominal, gluteal, and hip adductor muscles, using ultrasound. Muscle thickness was measured in both resting and contracted states. For secondary outcomes, physical performance (Functional Movement System score, McGill’s core stability test, and hip muscle power) and body composition analysis were evaluated. All assessments were performed at the beginning and end of the intervention.

Results:
39 participants (S+E group = 20, S group = 19) completed the study. The clinical characteristics and baseline functional status of each group did not differ significantly between the groups. After completion of the training, the S+E group showed more efficient contraction in most of the evaluated muscles. The resting muscle thickness did not differ significantly between the groups; however, the contracted muscle thickness in the S+E group was higher than that in the S group (p < 0.05). Physical performance and body composition were not significantly different between the two groups. No intervention-related complications were reported during the study.

Conclusion:
EMS seems to be a safe and reasonable modality for improving physical fitness in healthy individuals.
Dynamic coagulofibrinolytic responses under long-term VV-ECMO management without anticoagulation in a COVID-19-ARDS patient: A case report
Authors: Matsumoto Hironori , Kikuchi Satoshi , Murata Satoru , Ohshita Muneaki , Harima Yutaka , Annen Suguru , Mukai Naoki , Nakabayashi Yuki , Ogawa Shirou , Okita Mitsuo , Takeba Jun , Sato Norio 
Published: February 2023

Rationale:
Venovenous extracorporeal membrane oxygenation (ECMO) is recommended for the treatment of critically ill patients with acute respiratory distress syndrome due to coronavirus disease 2019 (COVID-19). However, ECMO management can cause both bleeding and thrombotic complications. There are insufficient coagulofibrinolytic data for appropriate ECMO management in patients with COVID-19.

Patient concerns:
A 48-year-old man with severe COVID-19-acute respiratory distress syndrome underwent long-term venovenous ECMO management for 48 days. Refractory oronasal bleeding developed on day 13, so the administration of unfractionated heparin was ceased for 29 days.

Diagnosis:
The patient showed dynamic coagulofibrinolytic responses associated with ECMO management, as shown by fibrin/fibrinogen degradation products, soluble fibrin, thrombin-antithrombin complex, and plasmin-α2-plasmin inhibitor complex elevations, suggesting the development of ECMO-induced coagulopathy.

Interventions:
We assessed coagulofibrinolytic markers to decide the appropriate timing for controlling excessive activation of coagulation by exchanging ECMO circuits. Moreover, viscoelastic hemostatic assays were used for adequate transfusion of blood products.

Outcomes:
Safe long-term ECMO management was completed, which was withdrawn on day 48. The patient was weaned off mechanical ventilation on day 57 and was transferred to another hospital for rehabilitation.

Lessons:
Monitoring the coagulofibrinolytic status using markers and viscoelastic hemostatic assays may be effective for safe long-term ECMO management even without anticoagulant therapy.
Intelligence as proxy phenotype providing insight into the heterogeneity of schizophrenia
Authors: Ren Hongyan , Yin Meiyu , Wang Qiang , Deng Wei , Ma Xiaohong , Zhao Liansheng , Li Xiaojing , Sham Pak , Li Ming , Li Shiwu , Li Tao 
Published: February 2023

AbstractSchizophrenia is a mental disorder constituting different symptom clusters. Its high heterogeneity in both pathophysiology and clinical manifestations hampered effective prevention and treatment. It has long been recognized that one of the core features of schizophrenia is its intellectual decline. Using the proxy-phenotype method (PPM), we tried to identify core genes, the expression of which in the dorsal lateral prefrontal cortex (DLPFC) showed a genetic dependence between intelligence (IT) and schizophrenia (SCZ). The result revealed ten genes of genetic dependence in their genetic expression in DLPFC between IT and schizophrenia. Further, a clustering analysis using the expression matrix of these ten genes identified four biotypes in our patient group. Subsequent phenotypic profiling of these four biotypes indicated a significant difference in working memory capacity, the gray matter volume (GMV) of five brain regions (lLimbicA_TempPole_2, rLimbicA_TempPole_2 rLimbicB_OFC_1, rContA_IPS_1 and rContB_PFClv_1), structural network and psychopathology. An in-vitro investigation of the biological functions of these core genes indicated their potentially critical role in neuronal growth, especially in dendritic spines. Our current study employed a novel statistical approach to identify the core genes associated with IT and explore the possibility of using the expression knowledge of these core genes to reduce the heterogeneity of schizophrenia. The results pinpointed one biotype that exhibited significant deficits in working memory, GMV in limbic and prefrontal areas, and also showed psychopathology of core negative symptom and worse outcomes.
Integrative multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci
Authors: Hodonsky Chani J. , Turner Adam W. , Khan Mohammad Daud , Barrientos Nelson B. , Methorst Ruben , Ma Lijiang , Lopez Nicolas G. , Mosquera Jose Verdezoto , Auguste Gaëlle , Farber Emily , Ma Wei Feng , Wong Doris , Onengut-Gumuscu Suna , Kavousi Maryam , Peyser Patricia A. , van der Laan Sander W. , Leeper Nicholas J. , Kovacic Jason C. , Björkegren Johan L.M. , Miller Clint L. 
Published: February 2023

AbstractGenome-wide association studies (GWAS) have identified hundreds of genetic risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWAS and the causal gene-regulatory mechanisms of these risk loci during atherosclerosis remain unclear. We incorporated local ancestry and haplotype information to identify quantitative trait loci (QTL) for gene expression and splicing in coronary arteries obtained from 138 ancestrally diverse Americans. Of 2,132 eQTL-associated genes (eGenes), 47% were previously unreported in coronary arteries and 19% exhibited cell-type-specific expression. Colocalization analysis with GWAS identified subgroups of eGenes unique to CAD and blood pressure. Fine-mapping highlighted additional eGenes of interest, includingTBX20andIL5. Splicing (s)QTLs for 1,690 genes were also identified, among whichTOR1AIP1andULK3sQTLs demonstrated the importance of evaluating splicing events to accurately identify disease-relevant gene expression. Our work provides the first human coronary artery eQTL resource from a patient sample and exemplifies the necessity of diverse study populations and multi-omic approaches to characterize gene regulation in critical disease processes.Study Design Overview
The association between proportion of night shifts and musculoskeletal pain and headaches in nurses: a cross-sectional study
Authors: Stavås Jon Are , Nilsen Kristian Bernhard , Matre Dagfinn 
Published: February 2023

ABSTRACTObjectivesTo investigate whether a higher proportion of night shifts is associated with a higher occurrence of musculoskeletal pain and headaches. Furthermore, to investigate whether sleep duration can mediate this potential association.MethodThe study included 684 nurses in rotating shift work (day, evening, night) who responded to a daily questionnaire about working hours, sleep, and pain for 28 consecutive days. The data were treated as cross-sectional data.ResultsA negative binomial regression analysis adjusted for age and BMI revealed that working a higher proportion of night shifts is not associated with a higher occurrence of musculoskeletal pain and headaches. On the contrary, those working ≥ 50 % night shifts had a significantly lower occurrence of pain in the lower extremities than those who worked <25 % night shifts (IRR 0.69 95 % CI 0.51, 0.94). There was no indication of a mediation effect with total sleep time (TST).ConclusionThe results of this study indicate that working a higher monthly proportion of night shifts is not associated with a higher occurrence of musculoskeletal pain and headaches.What is already known on this topic?A few studies have investigated the association between proportion of night shifts and musculoskeletal pain and headaches, but the findings are conflicting, and the studies are largely based on retrospective questionnaires.What this study addsThis study gives further knowledge about the association between proportion of night shifts and musculoskeletal pain and headaches.How this study might affect research, practice or policyThe results have implications for the design of future studies on the effect of shift work on musculoskeletal pain and headache. The negative effect of night shifts are not necessarily dose-dependent, and real-life studies must seek to account for the “healthy worker effect”.
Clonal Hematopoiesis of Indeterminate Potential Status is Associated with Left Main Artery Stenosis
Authors: Heimlich J. Brett , Raddatz Michael A. , Wells John , Vlasschaert Caitlyn , Olson Sydney , Threadcraft Marcus , Foster Kristoff , Boateng Emmanuel , Umbarger Kelsey , Su Yan Ru , Roden Dan M. , Barker Colin M. , Bick Alexander G. 
Published: February 2023

AbstractClonal hematopoiesis of indeterminate potential (CHIP) occurs as a result of acquired mutations in bone marrow progenitor cells. CHIP confers a twofold risk of atherosclerotic cardiovascular disease (ASCVD). However, there is limited data regarding specific cardiovascular phenotypes in this population. We recruited patients from the Vanderbilt University Medical Center cardiac catheterization laboratory and performed next generation sequencing to determine CHIP status. Multivariable logistic regression models and proportional odds models were used to assess the association between CHIP status and coronary angiography. We find nearly 1 in 5 patients undergoing coronary angiography have a CHIP mutation. Those with CHIP had a higher risk of having left main coronary artery disease compared to non-CHIP carriers. We additionally find that those with a specific CHIP mutation, ten eleven translocase 2(TET2)has a larger effect size on left main stenosis compared with other CHIP mutations. This is the first description of a specific atherosclerotic phenotype in CHIP and serves as a basis for understanding enhanced morbidity and mortality in CHIP.
The long COVID evidence gap: comparing self-reporting and clinical coding of long COVID using longitudinal study data linked to healthcare records
Authors: Knuppel Anika , Boyd Andy , Macleod John , Chaturvedi Nishi , Williams Dylan M 
Published: February 2023

AbstractThe term “long COVID” (LC) was coined in spring 2020 by individuals with ongoing symptoms following COVID-19, but it took until December 2020 for clinical codes to be created in order to record persistent post-COVID-19 illness and referrals within electronic health records (EHRs). Analysis of whole-population EHR databases have helped understand the epidemiology of LC; yet concerns exist about the completeness of accessible EHRs for LC. UK longitudinal population studies (LPS) collected self-reported data on COVID-19 and LC from early 2020 and deposited these data in the UK Longitudinal Linkage Collaboration (UK LLC) research database where they are systematically linked to the participants EHRs. Comparisons of LPS reported LC with recorded LC in the EHRs of the same individuals may be helpful in understanding the epidemiology of emerging conditions such as LC. We used data from 10 UK LPS in the UK LLC to investigate whether participants self-reporting LC had a LC diagnosis or referral code in their English EHR after 10 to 22 months of follow up. Of 6412 participants with COVID-19 symptom duration data and linkage to health records, 898 (14.0%) self-reported LC of any severity in LPS surveys. Among these, just 42 (4.7%; 95% CI: 3.5, 6.3) were identified with LC-related codes in EHRs. In individuals reporting debilitating LC, this proportion was only marginally higher (5.6%; 95% CI: 3.7, 8.3). Our data show a striking discrepancy between LC as perceived and reported by participants in LPS and evidence of LC recorded in their EHRs; and that this discrepancy was patterned by ethnicity and possibly by indicators of deprivation. Self-reported symptoms may not be reflected in coded EHRs due to factors including variations in individuals help seeking behaviours, clinician coding practices and the availability of appropriate codes. However, these considerations appear unlikely to provide a complete explanation for the substantial observed reporting discrepancy. These results may indicate substantial unmet clinical need, in keeping with patient reports of difficulties accessing healthcare and sub-optimal recognition of, and response to, their illness when they do. They may also indicate potential shortcomings of epidemiological research on LC based on EHR- or LPS-based ascertainment alone and illustrate the value of triangulation between LPS and EHR data where linked and made available through resources such as the UK LLC.