bluuebunny/crossref_metadata_2025_split huggingface dataset:
Вплив колатерального кровообігу на результати інвазивного лікування у хворих із гострим коронарним синдромом
Authors: Маслій Б. Я. 
Published: January 2023

Мета роботи: дослідити клінічний портрет хворих із розвинутими колатералям и на тлі ГКС та їх вплив на результати інвазивного лікування.
Матеріали і методи. У дослідження включено 135 пацієнтів, з них 105 чоловіків (77,78 %) та 30 жінок (22,22 %). Середній вік обстежених склав (61,81±1,13) року, у тому числі чоловіків – (60,15±0,91) року, жінок – (66,43±1,27) року, p<0,0009. У 113 (83,70 %) пацієнтів діагностовано ГКС з елевацією сегмента ST (STEMI), у 22 (16,30 %) – ГКС без елевації сегмента ST (NSTEMI). У хворих оцінювали колатеральний кровообіг за методикою Rentrop під час виконання коронароаніографії з наступною ангіопластикою та стентуванням інфаркт-залежної артерії. Залежно від розвитку КК усі пацієнти були поділені на дві групи: 1-ша – з добре розвинутими колатералями (2–3 бали за Rentrop), 2-га – із слаборозвинутим КК (0–1 бали за Rentrop). У цих групах порівнювали особливості клінічного перебігу ГКС, вплив коморбідності, розрахункову масу некрозу за ЕКГ, показники ехокардіоскопії, коронароангіографічні паралелі між ураженням різних відділів вінцевого русла та розвитком КК, безпосередні та віддалені наслідки інвазивного лікування. Ризики несприятливого прогнозу оцінювали за шкалою GRACE-2.
Результати досліджень та їх обговорення. За даними коронароангіографії, розвинутий КК (Rentrop 2–3) встановлено у 43 пацієнтів, а у 92 – недостатній КК або відсутність колатералів. Встановлено пряму залежність між ступенем обструкції коронарної артерії та наявністю добре розвинутих колатералей (r=0,316, p<0,001). За даними парціального кореляційного аналізу (з вилученням віку) простежувався певний зв’язок між наявністю КК та шестимісячним ризиком несприятливого прогнозу за шкалою GRACE-2 (r=0,205, p=0,018). Оцінка загальної смертності за весь період спостереження виявила дещо вищу смертність у групі пацієнтів, які мали розвинуті колатералі, порівняно з пацієнтами, у яких останніх не виявлено, відповідно, 25,58 % проти 17,39 %, однак статистично різниця виявилась недостовірною. При аналізі смертності упродовж 6 місяців після ІМ фактична смертність за наявності розвинутих колатералей була 9,3 %, а розрахункова за шкалою GRACE становила 15,24 %. Водночас ті ж показники у групі пацієнтів, у яких при коронароангіографії не виявлено колатералей, становили, відповідно, 3,26 % та 3,00 %, тобто у останніх фактична і розрахункова смертність виявилась ідентичною.
Колатералі краще розвинені у пацієнтів із тяжким стенозом коронарної артерії. У виборі тактики лікування гострого коронарного синдрому слід враховувати особливості колатерального кровообігу. На відносно короткому проміжку часу наявність колатерального кровотоку має позитивний вплив при гострому коронарному синдромі.
Reparative Game Creation: Designing For and With Psychosocial Disability
Authors: Stone Kara 
Published: January 2023

Abstract
This article proposes a design framework called Reparative Game Creation, a process of creating interactive media focused on healing, emotional acceptance, and accessibility for the psychosocially disabled. It is informed by disability studies, affect theory, anti-capitalist thought, and artist-scholarship on research creation and/or critical practice. Though much of game design and game studies focus on the end product or the player experience, this article instead focuses on the process of game design, and as such does not analyze particular games but instead proposes new ways of creating games informed by psychosocial disability.
Undetectable Starting Points: Rethinking “Passing” in Level Design through Queerness, Disability, and Roxy's Got Balls
Authors: DeAnda Michael Anthony , Straznickas Gracie Lu 
Published: January 2023

Abstract
In this article, the authors tease out meritocracy from level design by comparing “passing” game levels with “passing” as performances for survival by marginalized peoples. We use HIV to demonstrate passing as a response from the intersections of queerness, race, and disability to inform heuristics for level design that tease out meritocratic design practices. We finish by illustrating our heuristics in action through Roxy's Got Balls, an online drag queen bingo event.
How to Make Sino-Reformed Theology Possible?
Authors: Xu Ximian 
Published: December 2022

Abstract
This article aims to retrieve Abraham Kuyper’s theology to develop Reformed theology in mainland China. It shall argue that Kuyper’s concern about the varying contexts where theology is practiced shows an underdeveloped proto-Reformed contextual theology. Nonetheless, his idea of common grace serves as a conceptual apparatus through which his proto-Reformed contextual theology can underpin the construction of Sino-Reformed theology, a Reformed theology that is organically united with the history of Christianity while taking root in Chinese culture and interacting closely with the Chinese context. Such a contextualised Reformed theology can make Reformed faith an indigenous plant in the garden of Chinese Christianity on the one hand and prove conducive to the development of an organic Reformed community and theology on the other.
Contact and Conflict: Integral Experience in Classical Chinese and Reformational Philosophies
Authors: McIlhenny Ryan 
Published: December 2022

Abstract
This essay offers a comparative analysis of aspects of classical Chinese philosophy with those of Reformational (Neo-Calvinist) philosophy. Such aspects form a shared root in prioritizing temporal experience (over abstract reasoning) and conceptualizing the entirety of reality as contingent and relationally dependent. At the same time, however, what marks the divergence between the two philosophies is the underlying assumptions as to what this integral reality points toward – a directionality that is critical to meaning and being. For classical Chinese philosophy, the source and meaning of reality is found within reality itself, not beyond it, construing such reality not as independent and self-contained but necessary and sufficient. This conflicts with the notion of reality as contingent and dependent. From a Reformational perspective, on the other hand, reality (i.e., all of creation) is constituted as it stands in relation to an independent and necessary Creator. The crux of Reformational philosophy is that the origin and meaning of all reality must point outside of itself to its origin in God.
Reconstruction of Metaphorical Mapping as an Instrument of the Pre-translation Analysis of Poetry
Authors: Aksenova Anna 
Published: December 2022

Although it can help avoid far too literal translations of metaphorical expressions, the reconstruction of metaphorical mapping is still an unclaimed instrument of pre-translation analysis. This research aims at a pre-translation analysis of a book of poems, Babylon in a Jar (1998) by Andrew Hudgins, which has not been previously translated into Russian. The method for linguistic metaphor identification created by G. Steen is applied for the first time in this study as an instrument of pre-translation analysis. Firstly, key conceptual metaphors of the book are identified: death is departure, life is a journey, plants are people, and emotional intimacy is physical closeness. Secondly, the relationship between source and target domains is analysed. For example, the source domain for the metaphor people are plants is a daffodil, a tree, or a chinaberry. In Western cultures, a chinaberry symbolizes the tree of knowledge and in A. Hudgins’ poem, this idea is mapped onto knowledge about sinful human nature. Thirdly, translation strategies are outlined. In the translated version, another plant is introduced to preserve the original cross-domain mapping because the chinaberry tree is not familiar to Russian readers. Based on conceptual metaphor theory, this research seeks to integrate the reconstruction of metaphorical mapping into a pre-translation analysis, which allows for the preservation of the spirit of the original version. These insights advance interdisciplinary research on poetry interpretation and the practice of translation.
Epidemiology of Lateral Ligament Complex Tears of the Ankle in National Collegiate Athletic Association (NCAA) Sports: 2014-15 Through 2018-19
Authors: Chandran Avinash , Moffit Reagan E. , DeJong Lempke Alexandra F. , Boltz Adrian J. , Alexander Andrew S. , Robison Hannah J. , Kerr Zachary Yukio , Collins Christy L. , Wikstrom Erik A. 
Published: January 2023

Background: Epidemiological studies of lateral ankle sprains in NCAA sports are important in appraising the burden of this injury and informing prevention efforts. Purpose: To describe the epidemiology of lateral ankle sprains in NCAA sports during the 2014-15 through 2018-19 seasons. Study Design: Descriptive epidemiology study. Methods: Injury and exposure information collected within the NCAA Injury Surveillance Program (ISP) were examined. Counts, rates, and proportions of lateral ankle sprains were used to describe injury incidence by sport, event type (practices, competitions), season segment (preseason, regular season, postseason), injury mechanism (player contact, noncontact, and surface contact, injury history (new, recurrent), and time loss (time loss [≥1 day], non–time loss). Injury rate ratios (IRRs) were used to examine differential injury rates, and injury proportion ratios (IPRs) were used to examine differential distributions. Results: A total of 3910 lateral ankle sprains were reported (4.61 per 10,000 athlete exposures) during the study period, and the overall rate was highest in men’s basketball (11.82 per 10,000 athlete exposures). The competition-related injury rate was higher than the practice-related rate (IRR, 3.24; 95% CI, 3.04-3.45), and across season segments, the overall rate was highest in preseason (4.99 per 10,000 athlete exposures). Lateral ankle sprains were most often attributed to player-contact mechanisms in men’s (43.2%) and women’s sports (35.1%), although injuries were more prevalently attributed to player contact in men’s than in women’s sports (IPR, 1.23; 95% CI, 1.13-1.34). Overall, 49.7% of all lateral ankle sprains were time loss injuries. Conclusions: The findings of this study are consistent with previous epidemiological investigations of lateral ankle sprains among NCAA athletes. Results offer additional context on differential injury mechanisms between men’s and women’s sports and on injury risk across the competitive season. Future research may examine the effectiveness of deploying injury prevention programs before the start of a season.
Influence of elevated temperature on the microhardness and microstructure of carbon fiber reinforced polymers
Authors: Lee Se Woong , Han Seulgi , Kim Sang-il , Choi Sungmo 
Published: January 2023

Carbon fiber-reinforced polymer (CFRP) has attracted attention for the reinforcement and retrofitting of concrete structures. Thus, their degradation in elevated temperatures is important feature to investigate. Herein, influence of elevated temperatures on microstructure and microhardness properties of different types of CFRP was investigated. A series of CFRP plate-, sheet-, and bar-type samples were fired at 150, 250, 350, and 450°C. Crystal structural properties of epoxy resin matrices and carbon fibers in the CFRP composites were examined using X-ray diffraction analysis. An increase in surface defects was observed for the fired CFRP plates and bars; however, there was no significant difference between the microstructures of the fired CFRP sheets. Hardness of CFRP plates fired at 150 and 250°C substantially decreased from 0.67 to 0.62 and 0.47 GPa, respectively, compared to that of unfired CFRP plate. Similarly, hardness of CFRP bars fired at 150, 250, and 350°C decreased from 2.09 to 1.73, 1.63, and 0.62 GPa, which is reduced by 17, 22, and 70%, respectively, compared to that of unfired CFRP bar. Decrease in hardness is attributed to several factors, such as mechanical degradation in the resin matrix, fiber/matrix debonding, and an increase in microcracks on the surface.
Maize cytolines as models to study the impact of different cytoplasms on gene expression under heat stress conditions
Authors: Ardelean Ioana V. , Bălăcescu Loredana , Sicora Oana , Bălăcescu Ovidiu , Mladin Lia , Haș Voichița , Miclăuș Mihai 
Published: January 2023

Abstract
Background
Crops are under constant pressure due to global warming, which unfolds at a much faster pace than their ability to adapt through evolution. Agronomic traits are linked to cytoplasmic-nuclear genome interactions. It thus becomes important to understand the influence exerted by the organelles on gene expression under heat stress conditions and profit from the available genetic diversity. Maize (Zea mays) cytolines allow us to investigate how the gene expression changes under heat stress conditions in three different cytoplasmic environments, but each having the same nucleus. Analyzing retrograde signaling in such an experimental set-up has never been done before. Here, we quantified the response of three cytolines to heat stress as differentially expressed genes (DEGs), and studied gene expression patterns in the context of existing polymorphism in their organellar genomes.

Results
Our study unveils a plethora of new genes and GO terms that are differentially expressed or enriched, respectively, in response to heat stress. We report 19,600 DEGs as responding to heat stress (out of 30,331 analyzed), which significantly enrich 164 GO biological processes, 30 GO molecular functions, and 83 GO cell components. Our approach allowed for the discovery of a significant number of DEGs and GO terms that are not common in the three cytolines and could therefore be linked to retrograde signaling. Filtering for DEGs with a fold regulation > 2 (absolute values) that are exclusive to just one of the cytolines, we find a total of 391 up- and down-DEGs. Similarly, there are 19 GO terms with a fold enrichment > 2 that are cytoline-specific. Using GBS data we report contrasting differences in the number of DEGs and GO terms in each cytoline, which correlate with the genetic distances between the mitochondrial genomes (but not chloroplast) and the original nuclei of the cytolines, respectively.

Conclusions
The experimental design used here adds a new facet to the paradigm used to explain how gene expression changes in response to heat stress, capturing the influence exerted by different organelles upon one nucleus rather than investigating the response of several nuclei in their innate cytoplasmic environments.
Establishment and evaluation of an early prediction model of hepatorenal syndrome in patients with decompensated hepatitis B cirrhosis
Authors: Wang Shouhao , Zhou Zhewen , Xu Chengan , Chen Hanzhu , Ren Wenya , Yang Xingdi , Yin Qiaoqiao , Zheng Wei , Pan Hongying 
Published: January 2023

Abstract
Background and aim
In China, hepatorenal syndrome is a serious complication in the decompensated stage of hepatitis B cirrhosis, which requires early clinical intervention, so the early diagnosis of hepatorenal syndrome is crucial. This study establishes a new predictive model based on serum biomarkers for the early diagnosis of hepatorenal syndrome.

Methods
Patients with decompensated hepatitis B cirrhosis who met the inclusion and exclusion criteria were retrospectively enrolled. Patients were randomly assigned to the training dataset and validation dataset at a 7:3 ratio. Univariate and multivariate logistic regression analyses were used to screen the risk factors for hepatorenal syndrome. The identified risk factors were used to establish and verify a model.

Results
This study included 255 patients with decompensated hepatitis B cirrhosis, including 184 in the training group and 71 in the validation group. The multivariate logistic regression model was established in the training group and verified in the validation group. Logistic regression showed that hemoglobin (OR 0.938, 95% CI 0.908–0.969), total bilirubin (OR 1.014, 95% CI 1.008–1.021) and creatinine (OR 1.079, 95% CI 1.043–1.117) were independent risk factors for hepatorenal syndrome (P < 0.05). These were used to establish the model. In the training group and the validation group, the area under the ROC curve of the nomogram for the diagnosis of hepatorenal syndrome was 0.968 and 0.980, respectively.

Conclusion
The three serum biomarkers, including hemoglobin, total bilirubin and creatinine, can be used as independent early predictors of hepatorenal syndrome in patients with decompensated hepatitis B cirrhosis.
Biofilm elimination from infected root canals using four different single files
Authors: Hamed Sarah A. , Shabayek Sarah , Hassan Hayam Y. 
Published: December 2022

Abstract
Introduction
Enterococcus faecalis (E. faecalis) is the most commonly isolated bacterium from infected root canals. It is found in the form of a biofilm, which makes it more resistant to antimicrobials, and requires optimal chemomechanical strategies to maximize root canal disinfection.

Aim
To evaluate the efficacy of 4 different endodontic file systems against E. faecalis biofilm growth in root canals using colony-forming units per milliliter (CFU/mL) and scanning electron microscope (SEM).

Methods
Eighty-five extracted human mandibular premolars with straight root canals and apical diameters not larger than the #15 K-file were randomly selected. After performing a pilot study (n = 15) to determine the ideal incubation period for E. faecalis biofilm development, sixty-five root canals were infected with E. faecalis, incubated for 3 weeks, and then mechanically prepared using one of four single files (XP-endo Shaper, Hyflex EDM, One Curve, and Fanta. AFTM F One) (n = 15). Five infected root canals were excluded for the positive control. Five non-contaminated root canals were included for the negative control. Samples were collected using sterile paper points pre- and post-instrumentation to determine the bacterial load (CFU/mL). Root canals from each group were topographically evaluated at the coronal, middle, and apical segments using scanning electron microscope (SEM). Bacterial reduction data were estimated and statistically analyzed by Kruskal–Wallis and Mann–Whitney U tests (post hoc test) (P ≤ .05).

Results
XP-endo Shaper, Hyflex DEM, and One Curve significantly could eradicate E. faecalis biofilms in infected root canals with no significant difference among them compared to Fanta. AF™ F One.

Conclusion
None of the systems were capable of completely eliminating biofilms. XP-endo Shaper, Hyflex EDM, and One Curve mechanically eliminated E. faecalis biofilms compared to Fanta. AF™ F One from infected root canals.
Neuro-nanotechnology: diagnostic and therapeutic nano-based strategies in applied neuroscience
Authors: Shabani Leili , Abbasi Milad , Azarnew Zeynab , Amani Ali Mohammad , Vaez Ahmad 
Published: January 2023

AbstractArtificial, de-novo manufactured materials (with controlled nano-sized characteristics) have been progressively used by neuroscientists during the last several decades. The introduction of novel implantable bioelectronics interfaces that are better suited to their biological targets is one example of an innovation that has emerged as a result of advanced nanostructures and implantable bioelectronics interfaces, which has increased the potential of prostheses and neural interfaces. The unique physical–chemical properties of nanoparticles have also facilitated the development of novel imaging instruments for advanced laboratory systems, as well as intelligently manufactured scaffolds and microelectrodes and other technologies designed to increase our understanding of neural tissue processes. The incorporation of nanotechnology into physiology and cell biology enables the tailoring of molecular interactions. This involves unique interactions with neurons and glial cells in neuroscience. Technology solutions intended to effectively interact with neuronal cells, improved molecular-based diagnostic techniques, biomaterials and hybridized compounds utilized for neural regeneration, neuroprotection, and targeted delivery of medicines as well as small chemicals across the blood–brain barrier are all purposes of the present article.
The influence of male and female overweight/obesity on IVF outcomes: a cohort study based on registration in Western China
Authors: Liu Xiang , Shi Shengjia , Sun Jianhua , He Yuan , Zhang Zhou , Xing Junping , Chong Tie 
Published: January 2023

Abstract
Background
Overweight/obesity can affect fertility, increase the risk of pregnancy complications, and affect the outcome of assisted reproductive technology (ART). However, due to confounding factors, the accuracy and uniformity of published findings on IVF outcomes have been disputed. This study aimed to assess the effects of both male and female body mass index (BMI), individually and in combination, on IVF outcomes.

Methods
This retrospective cohort study included 11,191 couples undergoing IVF. Per the Chinese BMI standard, the couples were divided into four groups: normal; female overweight/obesity; male overweight/obesity; and combined male and female overweight/obesity. The IVF outcomes of the four groups were compared and analysed.

Results
Regarding the 6569 first fresh IVF-ET cycles, compared with the normal weight group, the female overweight/obesity and combined male/female overweight/obesity groups had much lower numbers of available embryos and high-quality embryos (p < 0.05); additionally, the fertilization (p < 0.001) and normal fertilization rates (p < 0.001) were significantly decreased in the female overweight/obesity group. The combined male/female overweight/obesity group had significant reductions in the available embryo (p = 0.002), high-quality embryo (p = 0.010), fertilization (p = 0.001) and normal fertilization rates (p < 0.001); however, neither male or female overweight/obesity nor their combination significantly affected the clinical pregnancy rate (CPR), live birth rate (LBR) or abortion rate (p > 0.05).

Conclusion
Our findings support the notion that overweight/obesity does not influence pregnancy success; however, we found that overweight/obesity affects the fertilization rate and embryo number and that there are sex differences.
Hyaluronic acid spacer in prostate cancer radiotherapy: dosimetric effects, spacer stability and long-term toxicity and PRO in a phase II study
Authors: Björeland Ulrika , Notstam Kristina , Fransson Per , Söderkvist Karin , Beckman Lars , Jonsson Joakim , Nyholm Tufve , Widmark Anders , Thellenberg Karlsson Camilla 
Published: January 2023

Abstract
Background
Perirectal spacers may be beneficial to reduce rectal side effects from radiotherapy (RT). Here, we present the impact of a hyaluronic acid (HA) perirectal spacer on rectal dose as well as spacer stability, long-term gastrointestinal (GI) and genitourinary (GU) toxicity and patient-reported outcome (PRO).

Methods
In this phase II study 81 patients with low- and intermediate-risk prostate cancer received transrectal injections with HA before external beam RT (78 Gy in 39 fractions). The HA spacer was evaluated with MRI four times; before (MR0) and after HA-injection (MR1), at the middle (MR2) and at the end (MR3) of RT. GI and GU toxicity was assessed by physician for up to five years according to the RTOG scale. PROs were collected using the Swedish National Prostate Cancer Registry and Prostate cancer symptom scale questionnaires.

Results
There was a significant reduction in rectal V70% (54.6 Gy) and V90% (70.2 Gy) between MR0 and MR1, as well as between MR0 to MR2 and MR3. From MR1 to MR2/MR3, HA thickness decreased with 28%/32% and CTV-rectum space with 19%/17% in the middle level. The cumulative late grade ≥ 2 GI toxicity at 5 years was 5% and the proportion of PRO moderate or severe overall bowel problems at 5 years follow-up was 12%. Cumulative late grade ≥ 2 GU toxicity at 5 years was 12% and moderate or severe overall urinary problems at 5 years were 10%.

Conclusion
We show that the HA spacer reduced rectal dose and long-term toxicity.