bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between depression and cancer risk among patients with diabetes mellitus: A population‐based cohort study
Authors: Shi‐Heng Wang , Hsu Le‐Yin , Lin Mei‐Chen , Wu Chi‐Shin 
Published: September 2023

AbstractBackgroundThe co‐occurrence of depression and diabetes mellitus has been linked to an increased risk of developing cancer. This study aimed to investigate whether depression further amplifies the risk of cancer among individuals with diabetes.MethodsThis population‐based matched cohort study utilized Taiwan's National Health Insurance claims database. A total of 85,489 newly diagnosed diabetic patients with depressive disorders were selected, along with 427,445 comparison subjects. The matching process involved age, sex, and the calendar year of diabetes onset. The average follow‐up duration for the two cohorts was 6.4 and 6.5 years, respectively. The primary outcome of interest was the occurrence of overall cancer or cancer at specific anatomical sites.ResultsThe adjusted hazard ratios for overall cancer incidence were 1.08 (95% CI, 1.05–1.11). For site‐specific cancers, depression exhibited significant associations with oropharyngeal, esophageal, liver, gynecological, prostate, kidney, and hematologic malignancies among patients with diabetes. Notably, a severity‐response relationship was observed, indicating that patients with recurrent episodes of major depressive disorders exhibited a higher incidence of cancer compared to those diagnosed with dysthymia or depressive disorder not otherwise specified. Furthermore, the strength of the association between depression and cancer risk was more pronounced among younger patients with diabetes as opposed to older adults. However, no significant relationship was observed between adherence to antidepressant treatment and cancer risk.ConclusionsThe findings of this study indicate a significant association between depression and an elevated risk of cancer among individuals diagnosed with diabetes. Future investigations should replicate our findings, explore the effects of pharmacological and non‐pharmacological treatments on cancer risk, and identify the underlying mechanisms.
Hyper IgE syndrome‐related disease treated with dupilumab: A case report
Authors: Kao Andrew S. , Deirawan Hany , Poowuttikul Pavadee , Daveluy Steven 
Published: September 2023

AbstractPhosphoglucomutase 3 (PGM3) catalyzes the glycosylation of immune system precursor proteins. Its impairment leads to severe infections and other developmental, musculoskeletal, and nervous system defects. We present a case of a 2‐month‐old female patient with recurrent infections and diffuse eczematous dermatitis recalcitrant to corticosteroids. A next‐generation sequencing NGS gene panel for inherited immune dysfunction syndromes revealed multiple variants of unknown significance in key immune regulators, specifically heterozygous mutation c.337C⟩G (p.Pro113Ala) on exon 4 of PGM3 as a novel variant in the PGM3 associated diseases. Off‐label use of dupilumab resulted in rapid improvement.
Arteriovenous thrombosis, a complication of induction therapy with all‐trans retinoic acid for acute promyelocytic leukemia: A case report
Authors: Tondro Anamag Farhad , Hashemi Negin , Sanaat Zohreh , Khadivi Heris Hengameh , Moslemi Mohammadreza 
Published: September 2023

Key Clinical MessageWe report a case of arterial and venous thrombosis during induction therapy. This case emphasizes considering some degree of caution for thrombotic events in APL patients which was represented in our case as abdominal pain. Rapid initiation of anticoagulation and preventive measures is suggested for better management of the condition.
Detection of the storage time of light bruises in yellow peaches based on spectrum and texture features of hyperspectral image
Authors: Li Bin , Zou Ji‐ping , Yin Hai , Liu Yan‐de , Zhang Feng , Ou‐yang Ai‐guo 
Published: September 2023

AbstractYellow peaches are soft, and they bruise easily; the bruised areas of them are prone to breed bacteria and molds, so the consumption and the safety of related products of yellow peaches are affected by the difference in the storage time of light bruises in them. In order to accurately distinguish of the storage time of light bruises in yellow peaches, the spectra of the sample bruised region were combined with texture features extracted based on gray‐level co‐occurrence matrix (GLCM), and the deep learning algorithm was used for modeling. A total of 80 samples were prepared in the experiment, and the hyperspectral images of them were acquired at four time periods (2, 8, 24, and 48 h), and the reflection spectral data as well as the texture features of the bruised samples were extracted from the hyperspectral images. First, the random forest (RF) and extreme gradient boosting (XGBoost) models were built based on spectral, texture, and spectral features combined with texture features (Feature Fusion 1), respectively, and the best model discrimination was the RF model under Feature Fusion 1, with an overall accuracy of 98.33%. In order to remove the redundant information of spectrum, the UVE and CARS algorithms were used to screen the normalized spectral feature data, and then, the texture features were combined again (Feature Fusion 2), and the RF and XGBoost models were built. The results show that the optimal model for distinguishing the storage time of yellow peaches after bruising is the RF model under Feature Fusion 2 (CARS), with an overall accuracy of 98.33%. In summary, this study shows that spectral features combined with texture features can be used to effectively improve the model's discrimination of storage time after bruising of yellow peaches, and it also provides a certain theoretical basis for hyperspectral imaging technology to discriminate storage time after bruising of fruits.
Graphene Oxide Nanosheets Hamper Glutamate Mediated Excitotoxicity and Protect Neuronal Survival In An In vitro Stroke Model
Authors: Tortella Lorenza , Santini Irene , Lozano Neus , Kostarelos Kostas , Cellot Giada , Ballerini Laura 
Published: September 2023

AbstractSmall graphene oxide (s‐GO) nanosheets reversibly downregulate central nervous system (CNS) excitatory synapses, with potential developments as future therapeutic tools to treat neuro‐disorders characterized by altered glutamatergic transmission. Excitotoxicity, namely cell death triggered by exceeding ambient glutamate fueling over‐activation of excitatory synapses, is a pathogenic mechanism shared by several neural diseases, from ischemic stroke to neurodegenerative disorders. In this work, CNS cultures were exposed to oxygen‐glucose deprivation (OGD) to mimic ischemic stroke in vitro, and it is show that the delivery of s‐GO following OGD, during the endogenous build‐up of secondary damage and excitotoxicity, improved neuronal survival. In a different paradigm, excitotoxicity cell damage was reproduced through exogenous glutamate application, and s‐GO co‐treatment protected neuronal integrity, potentially by directly downregulating the synaptic over‐activation brought about by exogenous glutamate. This proof‐of‐concept study suggests that s‐GO may find novel applications in therapeutic developments for treating excitotoxicity‐driven neural cell death.
Enantioselective Dearomative [4+2] Cycloaddition Reaction of 1‐Naphthols with In‐Situ Generated ortho‐Quinone Methides
Authors: Ranjan Sahoo Sushree , Gupta Khushboo , Singh Vinod K. 
Published: September 2023

AbstractWe disclose a catalytic, enantioselective dearomative reaction of non‐functionalized 1‐naphthols, which poses a synthetic challenge to organic chemists because of the relative ease of rearomatization via the elimination of a proton. In this work, the direct dearomatization of non‐functionalized 1‐naphthols was achieved through a chiral phosphoric acid (CPA) catalyzed enantioselective dearomative [4+2] cycloaddition reaction with in‐situ generated ortho‐quinone methides (o‐QMs). The reported convergent method allows the use of readily available simple 1‐naphthols without pre‐functionalization, furnishing a variety of naphthopyran derivatives in good yields (up to 96 %) and moderate to excellent enantioselectivities (up to >99 % ee) under mild reaction conditions. The observed regio‐, diastereo‐, and enantioselectivities are the keys to the success of the current strategy utilizing o‐QM as a diene surrogates, in combination with CPA catalysis.
Structural and Chemical Properties of NiOx Thin Films: Oxygen Vacancy Formation in O2 Atmosphere
Authors: Blume Raoul , Calvet Wolfram , Ghafari Aliakbar , Mayer Thomas , Knop‐Gericke Axel , Schlögl Robert 
Published: September 2023

AbstractNiOx films on Si(111) were put in contact with oxygen at elevated temperatures. During heating and cooling in oxygen atmosphere Near Ambient Pressure (NAP)‐XPS and ‐XAS and work function (WF) measurements reveal the creation and replenishing of oxygen vacancies in dependence of temperature. Oxygen vacancies manifest themselves as a distinct O1s feature at 528.9 eV on the low binding energy side of the main NiO peak as well as by a distinct deviation of the Ni2p3/2 spectral features from the typical NiO spectra. DFT calculations reveal that the presence of oxygen vacancies leads to a charge redistribution and altered bond lengths of the atoms surrounding the vacancies causing the observed spectral changes. Furthermore, we observed that a broadening of the lowest energy peak in the O K‐edge spectra can be attributed to oxygen vacancies. In the presence of oxygen vacancies, the WF is lowered by 0.1 eV.
Photo‐Electro‐Biochemical H2 Production Using the Carbon Material‐Based Cathode Combined with Genetically Engineered Escherichia coli Whole‐Cell Biocatalysis
Authors: Honda Yuki , Yuki Risa , Hamakawa Reina , Fujii Hiroshi 
Published: September 2023

AbstractAbio/bio hybrids, which incorporate biocatalysts that promote efficient and selective material conversions under mild conditions into existing catalytic reactions, have attracted considerable attention for developing new catalytic systems. This study constructed a H2‐forming biocathode based on a carbon material combined with whole‐cell biocatalysis of genetically‐engineered‐hydrogenase‐overproducing Escherichia coli for the photoelectrochemical water splitting for clean H2 production. Low‐cost and abundant carbon materials are generally not suitable for H2‐forming cathode due to their high overpotential for proton reduction; however, the combination of the reduction of an organic electron mediator on the carbon electrode and the H2 formation with the reduced mediator by the redox enzyme hydrogenase provides a H2‐forming cathodic reaction comparable to that of the noble metal electrode. The present study demonstrates that the recombinant E. coli whole cell can be employed as a part of the H2‐forming biocathode system, and the biocathode system wired with TiO2 photoanode can be a photoelectrochemical water‐splitting system without external voltage assistance under natural pH. The findings of this study expand the feasibility of applications of whole‐cell biocatalysis and contribute to obtaining solar‐to‐chemical conversions by abio/bio hybrid systems, especially for low‐cost, noble‐metal‐free, and clean H2 production.
Optimization and validation of in vivo flow cytometry chimeric antigen receptor T cell detection method using CD19his indirect staining
Authors: Zaninelli Silvia , Meli Cristian , Borleri Gianmaria , Quaroni Michele , Pavoni Chiara , Gaipa Giuseppe , Biondi Andrea , Introna Martino , Golay Josée , Rambaldi Alessandro , Rambaldi Benedetta 
Published: September 2023

AbstractCD19‐targeted chimeric antigen receptor T (CAR‐T) cell therapy has shown unprecedented results in patients with B cell relapsed/refractory acute lymphoblastic leukemia (R/R‐ALL) and B cell non‐Hodgkin lymphomas where no other curative options are available. In vivo monitoring of CAR‐T cell kinetics is fundamental to understand the correlation between CAR‐T cells expansion and persistence with treatment response and toxicity development. The aim of this study was to define a robust, sensitive, and universal method for CAR‐T cell detection using flow cytometry. We set up and compared with each other three assays for CD19 CAR‐T cell detection, all based on commercially available reagents. All methods used a recombinant human CD19 protein fragment recognized by the single‐chain variable fragment of the CAR construct. The two indirect staining assays (CD19his + APC‐conjugated antihistidine antibody and CD19bio + APC‐conjugated antibiotin antibody) showed better sensitivity and specificity compared with the direct staining with CD19‐FITC, and CD19his had a better cost‐effective profile. We validated CAR detection with CD19his with parallel quantitative real‐time polymerase chain reaction data and we could demonstrate a strong positive correlation. We also showed that CD19his staining can be easily included in a multicolor flow cytometry panel to achieve additional information about the cell phenotype of CAR‐T cell positive subpopulations. Finally, this method can be used for different anti‐CD19 CAR‐T cell products and for different sample sources. These data demonstrate that detection of CAR‐T cells by CD19his flow cytometry staining is a reliable, robust, and broadly applicable tool for in vivo monitoring of CAR‐T cells.
Thermal refuge use and parasitism: Spatiotemporal variation in anchor worm and lamprey wounds on Klamath redband trout
Authors: Ortega Jordan D. , Hahlbeck Nicholas , Derrickson Chris , Tinniswood William , Levi Taal , Armstrong Jonathan 
Published: September 2023

AbstractClimate warming is increasing maximum temperatures during summer such that they more frequently exceed the thermal tolerances of ectotherms, particularly cold‐water fishes. One way that species can avoid thermal stress is by moving to thermal refuge habitats. Thermal refuges remain suitably cool during summer and are often complementary to foraging, spawning, and rearing habitats. Although the benefits associated with the thermal aspects of refuges are well studied, much less is known about potential costs associated with nonthermal aspects. For example, crowding of cold‐water fishes into seasonal refuge habitats could increase parasite loads and cause declines in fitness. We assessed lamprey and anchor worm parasitism in Upper Klamath Lake where adfluvial redband trout (Oncorhynchus mykiss newberrii) move to thermal refuge habitats during summer. We sampled trout in Upper Klamath Lake during spring and in adjacent thermal refuge habitats during summer. We also evaluated survival as a function of lamprey wounding using motion‐sensing radio tags. There was a fourfold decline in the number of lamprey wounds on trout upon the onset of thermal refuge use. In contrast, cases of severe anchor worm (≥20 sores) increased threefold during thermal refuge use. Survival in thermal refuge was not different for lamprey‐wounded trout than for trout that migrated to thermal refuge without lamprey wounds. We found that both parasites were absent in a lotic population of redband trout downstream that lacked access to thermal refuge. Thus, the effects of seasonal refuge use on parasite load varied depending on the parasite taxon considered and local habitat conditions, implying that managers will likely require empirical data for focal habitats and taxa to understand how parasitism affects thermal refuge use.
Ligand and Linkage Isomers of Bis(ethylthiocarbamato) Copper Complexes with Cyclic C6H8 Backbone Substituents: Synthesis, Characterization, and Antiproliferation Activity
Authors: Bajaj Kritika , Andres Sarah A. , Hofsommer Dillon T. , Chekwube Michael Okolocha , Mashuta Mark S. , Bates Paula J. , Buchanan Robert M. , Grapperhaus Craig A. 
Published: September 2023

AbstractA series of isomeric bis(alkylthiocarbamate) copper complexes have been synthesized, characterized, and evaluated for antiproliferation activity. The complexes were derived from ligand isomers with 3‐methylpentyl (H2L2) and cyclohexyl (H2L3) backbone substituents, which each yield a pair of linkage isomers. The thermodynamic products CuL2a/3a have two imino N and two S donors resulting in three five‐member chelate rings (555 isomers). The kinetic isomers CuL2b/3b have one imino and one hydrazino N donor and two S donors resulting in four‐, six‐, and five‐member rings (465 isomers). The 555 isomers have more accessible CuII/I potentials (E1/2=−811/−768 mV vs. ferrocenium/ferrocene) and lower energy charge transfer bands than their 465 counterparts (E1/2=−923/‐854 mV). Antiproliferation activities were evaluated against the lung adenocarcinoma cell line (A549) and nonmalignant lung fibroblast cell line (IMR‐90) using the MTT assay. CuL2a was potent (A549EC50=0.080 μM) and selective (IMR‐90EC50/A549EC50=25) for A549. Its linkage isomer CuL2b had equivalent A549 activity, but lower selectivity (IMR‐90EC50/A549EC50=12.5). The isomers CuL3a and CuL3b were less potent with A549EC50 values of 1.9 and 0.19 M and less selective with IMR‐90EC50/A549EC50 ratios of 2.3 and 2.65, respectively. There was no correlation between reduction potential and A549 antiproliferation activity/selectivity.
Optimization of geometric parameters of hydraulic turbine runner in turbine mode based on ISMA and BPNN
Authors: Wang Yameng , Chen Jinbao , Zhang Lihong , Zheng Yang 
Published: September 2023

AbstractThe hydraulic turbine in turbine mode (TMHT) has significant advantages in residual energy recovery, but rapid optimization of its runner parameters has always been a challenge. To address this issue, the optimization algorithm ISMA‐BPNN is proposed based on the improved slime mold algorithm (ISMA) and back propagation neural network (BPNN). First, an efficiency characteristic neural network (ECNN) and a water head characteristic neural network (HCNN), which take the geometric parameters of the runner as input, and the efficiency and water head as outputs, respectively, are constructed by combining the orthogonal test‐based sample data, computational fluid dynamics (CFD), and BPNN. Then, the slime mold algorithm is improved and the optimal runner geometric parameters are obtained based on the ISMA, ECNN, and HCNN, to achieve rapid optimization of the TMHT runner. Finally, the CFD‐based numerical calculation accuracy is verified through real machine tests, and the feasibility of the ISMA‐BPNN‐based rapid optimization strategy for TMHT performance is further verified through CFD numerical simulation.
An insight into a combined effect of backsheet and EVA encapsulant on field degradation of PV modules
Authors: Buerhop Claudia , Pickel Tobias , Stroyuk Oleksandr , Hauch Jens , Peters Ian Marius 
Published: September 2023

AbstractPolymer components, in particular, backsheets (BSs) and ethylene‐vinyl acetate (EVA) encapsulants, play a crucial role in the degradation of commercial silicon photovoltaic (PV) modules. Degradation mechanisms depend in a complex way on the composition and properties of all involved polymers. In this study, we demonstrate that differences in the composition of EVA encapsulants, in particular, the presence of additives, such as UV blockers, affect the degradative processes in a decisive way, even for modules with identical BSs. A combination of spectral, imaging, and electrical characterization techniques applied in a mixed lab/field study showed that the field aging of PV modules with the same BSs and different encapsulant components results in the development of different degradation signs, such as insulation resistance loss, corrosion of metal interconnects, water ingress, oxidation depth in the encapsulant, and potential‐induced degradation, depending on the presence of additives in the encapsulant. The present study provides an outlook on the complex influence of polymer components on the lifetime and performance of silicon PV modules.
Characteristics of choice and satisfaction regarding the use of ultraviolet blockers in the golf population in Republic of Korea: A quantitative study
Authors: Choi Jiahn , Kwon Ki Han 
Published: September 2023

AbstractBackground and AimsKorea's golf population surpassed 5 million (5.15 million) as of 2020 according to data analyzed by Shinhan Financial Investment in 2021. Due to the continuous increase in the golf population, it is necessary to study the use of specific sunscreens. Men and women are using sunscreen selective attributes based on the actual use and perception of sunscreens for life. A questionnaire survey was conducted for an analysis of the effect of product satisfaction.MethodsStatistical processing of materials collected by the data analysis method is analyzed using the Statistical Package for Social Science WIN 25.0 statistical package program through the process of data coding and data cleaning.ResultsThis exercise was done under 3–4 h of strong ultraviolet (UV) rays, so products that have ensured the durability of UV protection are needed. Among the demographic characteristics of the golf population, gender, age, academic background, occupation, marriage status, and monthly income were investigated, and it was confirmed that the information path of a particular product was affected by the choice of purchase, increasing satisfaction and repurchase.ConclusionAn analysis of the paper's survey showed that men's awareness and interest in sunscreens increased. It is expected that differentiated strategies will be needed for products that match the actual conditions and aptitudes of the effective golf population.
Vitamin B12 effectiveness in the management of hospitalized COVID‐19 and its clinical outcomes and complications: A randomized clinical trial
Authors: Erfani Zahra , Alizadeh Nafiseh , Faraji Neda , Teymouri Alireza 
Published: September 2023

AbstractBackground and AimsSince 2019, severe acute respiratory syndrome coronavirus 2, has spread and challenged the health care system for treatment which is mainly limited to supportive care. It is well‐established that malnutrition impedes the immunity in human bodies, and makes it vulnerable to microorganisms. Vitamin B12 is one of the agents that has critical roles in body systems. Thus, the following clinical trial was conducted to assess its possible therapeutic value in COVID‐19 patients.MethodThe present randomized clinical trial was carried out in Baharlou Hospital, and patients with confirmed COVID‐19 infection within 24 h of admission were included. We used quadruple blocks randomization to divide patients into groups of case and control. The case group received 1000 mg of vitamin B12, daily for 7 day while the patients in control group were administered distilled water as placebo. The studied outcomes were duration of hospitalization, need for intensive care unit (ICU), mechanical ventilation, mortality rate and laboratory findings. The statistical analysis was done via SPSS version 22.ResultsAfter implementing inclusion and exclusion criteria, 34 participants were included in the study, 20 of which were male. Serum levels of creatinine, LDH (Lactate dehydrogenase), Ferritin, and CRP (C‐reactive protein) had decreased in both groups. The improving changes of CRP, LDH, ferritin and creatinine was higher in case group. The increase of Alanine Transaminase and D‐dimer was higher in control group. however there was no statistically significant difference. More patients were admitted to ICU in the control group but the difference was not statistically significant. Duration of hospitalization did not differ statistically between the groups. No in hospital mortality has been recorded.ConclusionOur study suggests that vitamin B12 supplementation seem to have curative effect in COVID‐19. Nutritious diet is necessary for proper functioning of the immune system. Since malnutrition is associated with poor prognosis in COVID‐19 patients, and limited number of participants in this study, we suggest performing meta‐analysis on similar studies to reach reliable result.