bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zwitterionic Electrochemiluminescence Biointerface Contributes to Label‐Free Monitoring of Exosomes Dynamics in a Fluidic Microreaction Device
Authors: Cao Yue , Wang Jian‐Xiao , Lin Chen , Geng Yu‐Qian , Ma Cheng , Zhu Jun‐Jie , Wang Leyong , Zhu Wenlei 
Published: February 2023

AbstractThe competence to construct sensing platforms capable of selective manipulation in complex biological fluids undoubtedly underpins critical future advances in healthcare. Despite the fact that electrochemiluminescence (ECL) has long been an influential technology for clinical diagnosis worldwide, ECL interface that optimizes fouling resistance has been mimicked less often, especially in an integrated platform. Herein, ECL transducer is prepared by the integration of protonated g‐C3N4 and Ti3C2Tx MXene nanosheets, displaying enhanced charge injection/transfer, and inherent catalytic capacities for coreactant ECL. Mussel‐bioinspired polydopamine was exploited as a thin, surface‐adherent substrate to coat the solid‐state transducer and further initiate secondary reactions via Michael Addition for tailing recognition element and zwitterionic segment. This architecture guarantees not only the least suppression of ECL performance but also desired antifouling properties, ensuring < 7.45% of ECL loss after 96 h of exposure to complex biological fluids. Creatively, a highly integrated platform is equipped with the established biointerface, gas diffusion electrode, and fluidic ECL microreactor, affording high‐performance exosome checking and dynamics tracking in a non‐label manner. Our study provides a general design strategy to obtain a robust antifouling ECL sensing interface based on zwitterionic chemistries and provides a fresh perspective in developing point‐of‐care and implantable ECL devices.
Multifunctional Scaffold for Osteoporotic Pathophysiological Microenvironment Improvement and Vascularized Bone Defect Regeneration
Authors: Zhao Yanan , Kang Honglei , Wu Xiaopei , Zhuang Pengzhen , Tu Rong , Goto Takashi , Li Feng , Dai Honglian 
Published: February 2023

AbstractOsteoporosis is a degenerative bone disease resulting from bone homeostasis imbalance regulated by osteoblasts and osteoclasts. Treating osteoporotic bone defects tends to be more difficult due to suppressed osteogenic differentiation, hyperactive osteoclastogenesis, and impaired angiogenesis. Hence, a drug carrier system composed of gelatin‐coated hollow mesoporous silica nanoparticles (HMSNs/GM) loaded with pro‐osteogenic parathyroid (PTH) and anti‐osteoclastogenic alendronate (ALN) is constructed and compounded into calcium magnesium phosphate cement (MCPC). The spatial‐temporal release of ions and drugs, controllable degradation rate, and abundant pore structure of MCPC composites enhance osteoporotic bone regeneration in ovariectomized rats by accelerating vascularization, promoting osteogenic differentiation and mineralization, and inhibiting osteoclastogenesis and bone resorption. The MCPC/HMSNs@ALN‐PTH/GM demonstrates a synergistic threefold effect on osteogenesis, osteoclastogenesis, and angiogenesis. It improves the osteoporotic pathophysiological microenvironment and promotes osteoporotic vascularized bone defect regeneration, holding huge potential for other functional biomaterials design and clinical management.
Tuning the Coordination Environment of Carbon‐Based Single‐Atom Catalysts via Doping with Multiple Heteroatoms and Their Applications in Electrocatalysis
Authors: Qi Zhijie , Zhou Yan , Guan Runnan , Fu Yongsheng , Baek Jong‐Beom 
Published: February 2023

AbstractCarbon‐based single‐atom catalysts (SACs) are considered to be a perfect platform for studying the structure–activity relationship of different reactions due to the adjustability of their coordination environment. Multi‐heteroatom doping has been demonstrated as an effective strategy for tuning the coordination environment of carbon‐based SACs and enhancing catalytic performance in electrochemical reactions. Herein, recently developed strategies for multi‐heteroatom doping, focusing on the regulation of single‐atom active sites by heteroatoms in different coordination shells, are summarized. In addition, the correlation between the coordination environment and the catalytic activity of carbon‐based SACs are investigated through representative experiments and theoretical calculations for various electrochemical reactions. Finally, concerning certain shortcomings of the current strategies of doping multi‐heteroatoms, some suggestions are put forward to promote the development of carbon‐based SACs in the field of electrocatalysis.
Piezocatalytic 2D WS2 Nanosheets for Ultrasound‐Triggered and Mitochondria‐Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism‐Targeted Chemotherapy
Authors: Truong Hoang Quan , Huynh Kim Anh , Nguyen Cao Thuy Giang , Kang Ji Hee , Dang Xuan Nghia , Ravichandran Vasanthan , Kang Han Chang , Lee Minjong , Kim Jong‐Eun , Ko Young Tag , Lee Tae Il , Shim Min Suk 
Published: February 2023

AbstractPiezoelectric nanomaterials that can generate reactive oxygen species (ROS) by piezoelectric polarization under an external mechanical force have emerged as an effective platform for cancer therapy. In this study, piezoelectric 2D WS2 nanosheets are functionalized with mitochondria‐targeting triphenylphosphonium (TPP) for ultrasound (US)‐triggered, mitochondria‐targeted piezodynamic cancer therapy. In addition, a glycolysis inhibitor (FX11) that can inhibit cellular energy metabolism is loaded into TPP‐ and poly(ethylene glycol) (PEG)‐conjugated WS2 nanosheet (TPEG‐WS2) to potentiate its therapeutic efficacy. Upon US irradiation, the sono‐excited electrons and holes generated in the WS2 are efficiently separated by piezoelectric polarization, which subsequently promotes the production of ROS. FX11‐loaded TPEG‐WS2 (FX11@TPEG‐WS2) selectively accumulates in the mitochondria of human breast cancer cells. In addition, FX11@TPEG‐WS2 effectively inhibits the production of adenosine triphosphate . Thus, FX11@TPEG‐WS2 exhibits outstanding anticancer effects under US irradiation. An in vivo study using tumor‐xenograft mice demonstrates that FX11@TPEG‐WS2 effectively accumulated in the tumors. Its tumor accumulation is visualized using in vivo computed tomography . Notably, FX11@TPEG‐WS2 with US irradiation remarkably suppresses the tumor growth of mice without systemic toxicity. This study demonstrates that the combination of piezodynamic therapy and energy metabolism‐targeted chemotherapy using mitochondria‐targeting 2D WS2 is a novel strategy for the selective and effective treatment of tumors.
Ultra‐Stretchable Multicolor Fluorescent Hydrogels Based on Polymer Networks Involving both Strong and Weak Crosslinks
Authors: Li Wanning , Zhang Hao , Lu Wei , Zhang Yi , Zheng Tianjiang , Yang Guilin , Chen Tao 
Published: February 2023

AbstractOwing to their inherent soft wet nature and the capacity to offer tunable emission color/intensity responses, multicolor fluorescent polymeric hydrogels (MFPHs) are attracting tremendous research interests. However, most of the reported MFPHs suffer from poor stretchability, thus restricting their versatile uses in artificial muscles, soft robotics, and so on. In this study, a robust type of lanthanide coordinated MFPHs with an ultra‐stretchability of over 1200% is designed and prepared. It is found that the ultra‐stretchability originates from the unique polymer network structure, in which a small quantity of strong crosslinking interactions (polymer chain entanglement/fixation around the nano‐clay and lanthanide coordination) are utilized to ensure the polymer network integrity, and a large quantity of hierarchical (single, double, and quadruple) hydrogen‐bonding interactions are designed to efficiently dissipate energy. Furthermore, a braiding strategy is proposed to tightly twist several hydrogel stripes into mechanical strong hydrogel ropes that still keep the ultra‐stretchability (>1000%) but can lift heavy weights >350 times their own weight. This study provides new insights into the design of ultra‐stretchable fluorescent hydrogels, and is expected to inspire the future development of multifunctional artificial hydrogel muscles.
Molecular Dynamics Investigation of Hetero Coalescence between Two Ih Ag55 and Cu55 Clusters at Atomic Scale
Authors: Liu Jinhan , Zhang Lin 
Published: February 2023

AbstractMolecular dynamics simulations are performed to explore the coalescence of the two hetero magic Ag55 and Cu55 clusters having icosahedral packing at room temperature, and the structural changes of the alloying Ag–Cu clusters at elevated temperatures. The simulation results reveal the influence of the contacting distances and relative orientations between the two clusters on the coalescing processes as well as the packing patterns of the coalesced binary clusters on heating. The activation energy is used to describe the energy required to initiate the coalescence. The Lode–Nadai parameter's distributions of the coalesced clusters provide more insight into the loading states on the atoms during different stages. The results show that the two clusters appear to form the neck involving twist and “slip” in the initial stage of the coalescence, and the Ag atoms present significant diffusion along the facets of the Cu cluster. As the temperature increases, different packing structures including Icosahedron, core/shell metastable, core@partial‐shell, and half Cu‐half Ag patterns occur.
Nanoarchitectonics of Triboelectric Nanogenerator for Conversion of Abundant Mechanical Energy to Green Hydrogen
Authors: Ghosh Kalyan , Iffelsberger Christian , Konečný Martin , Vyskočil Jan , Michalička Jan , Pumera Martin 
Published: February 2023

AbstractIn the present world, the high energy demand rapidly depletes existing fossil fuel reserves, urging the necessity to harvest energy from clean and renewable resources. In this study, the use of a triboelectric nanogenerator (TENG) is shown beyond the conventional practice of use in self‐powered electronics, to the production of green hydrogen from renewable mechanical energy. For the first time the use of a magnetic covalent organic framework composite as positive triboelectric material for a contact‐separation mode TENG (CS‐TENG) in which MXene incorporated polydimethylsiloxane (PDMS) film serves as negative triboelectric material, is demonstrated. A facile way of incorporating micropatterns on the surface of PDMS/MXene film is shown utilizing the advantages of 3D printing technology. The CS‐TENG harvests energy from simple mechanical actions such as human handclapping and toe‐tapping. The energy from such low‐scale mechanical actions is applied for water electrolysis. Scanning electrochemical microscopy is employed to confirm the evolution of hydrogen and oxygen by the harvested electrical energy from mechanical actions. This research is expected to pave the way for producing green hydrogen anywhere, by utilizing the mechanical energy from nature such as raindrops, wind, and the movement of vehicles.
Regulating Na Occupation in P2‐Type Layered Oxide Cathode for All‐Climate Sodium‐Ion Batteries
Authors: Liu Siying , Wan Jing , Ou Mingyang , Zhang Wen , Chang Miao , Cheng Fangyuan , Xu Yue , Sun Shixiong , Luo Cheng , Yang Kai , Fang Chun , Han Jiantao 
Published: February 2023

AbstractP2‐type Na2/3Ni1/3Mn2/3O2 (NNMO) has been investigated as one of the promising cathode materials of sodium‐ion batteries (SIBs) due to a low‐cost and wide‐temperature‐range adaptability. However, its application faces a number of obstacles because of the poor cycling stability and bad rate capabilities. Herein, by accommodating more Na‐ions at the e‐site (Nae) in P2‐type NNMO, which is thermodynamically more stable, P2‐type layered oxides (Nae/Naf > 1.64) with outstanding electrochemical performance are obtained. Specifically, the Na0.696Ni0.329Mn0.671O2 (NM‐2) exhibits a remarkable capacity retention of 71.9% after 1000 cycles at 1C and an excellent rate capability of 54.33 mAh g−1 at 50C. In addition, NM‐2 exhibits a wide temperature working range, even at extreme temperatures for batteries (−30 or 60 °C), it still shows a capacity close to room temperature and good cycle stability compared with 25 °C. These performances are demonstrated to be attributed to the fast kinetics of the Na ions in the Nae site, which has a lower energy barrier compared to Naf (0.8301 eV for edge sites and 1.0664 eV for face sites). This work gives a fundamental understanding of the Na‐storage mechanism in Na2/3Ni1/3Mn2/3O2, and also provides a universal strategy to improve the rate and cycling life of P2‐type layered oxide cathode materials.
Differentiated Ionic Electroresponse of Asymmetric Bio‐Hydrogels with Unremitting Power Output
Authors: Pan Xinglong , Jin Yakang , Zhou Yi , Wang Xiao‐Qiao , Lu Wanheng , He Jiaqing , Ho Ghim Wei 
Published: February 2023

AbstractCytomembranes with efficient ionic selectivity and energy circulation, essential for biological activities in multicellular organisms, are a source of inspiration for man‐made biomedical devices. However, current man‐made soft systems mainly imitate simple and passive cytomembranes behaviors, restrained by the grand challenge that lies at the meeting point of synchronous engineering of both (dynamic) ionic selectivity and (passive) transcellular‐like potential in one structure. Here a dynamically differentiated ionic electroresponse and passive incessant power output of an asymmetric bio‐hydrogel constructed using a simple self‐propagative flow approach are reported. The unprecedented freely formed p and n analogue hydrogels yield a transcellular‐like potential (110–200 mV) in response to diverse stimuli—where the cathode or anode is capable of perceivable electroresponse to water and/or salt media, respectively. A single hydrogel can generate an output power density of 135–190 mW m−2 superior to most bio‐inspired soft and/or green power sources. The scalable manufacturing and proof‐of‐concept demonstration elucidate the feasibility of mobilizing passive and dynamic behaviors in one structure. This work has the potential for realizing high‐performance soft power sources in parallel to electrostimulation for neural excitation/inhibition, extending into the previously inaccessible region of biomedical applications.
Organic Eutectic Mixture Incorporated with Graphene Oxide Sheets as Lithiophilic Artificial Protective Layer for Dendrite‐Free Lithium Metal Batteries
Authors: Xu Lei , Zhang Qicheng , Niu Shuzhang , Wang Xin , Lian Qing , Huang Yulan , Shi Run , Amini Abbas , Cheng Chun 
Published: February 2023

AbstractFor wide and safe applications of Li metal batteries, the suppression of Li dendrite growth during cycling is the most crucial yet challenging topic. In this work, an artificial protective interlayer of GO‐BQ@LiTFSI (GBL) is designed to overcome this issue. The GBL interlayer is prepared by incorporating graphene‐oxide sheets with a liquid organic eutectic mixture of 1,4‐benzoquinone and bis (trifluoromethane) sulfonamide lithium salt. With the exceptional merits of these functional materials, the incorporation endows the GBL interlayer with rich lithiophilic active sites, good ionic conductivity, superior thermal stability and compatibility with the electrolyte, and the precursor supply stations for the formation of a compact and LiF‐rich solid‐electrolyte interface (SEI). Consequently, the GBL effectively promotes the uniform nucleation of Li at low over‐potentials and regulates the Li‐ion flux, leading to the formation of planar Li metal. After utilizing the GBL interlayer in the Li||Li symmetric cells, high electrochemical stability for 600 h is achieved at a current density of 3 mA cm−2 and a capacity of 3 mAh cm−2. Remarkably, this modification enables Li||LiFePO4 full cells with 1600 cycles at 1C and a high‐capacity retention of 95.23% with a cathode mass loading of ≈6 mg cm−2.
Tuning of morphological, crystallographic, and optoelectronic properties of CuSCN by electrodeposition
Authors: Uda Kyota , Tsuda Yuki , Nakamura Tensho , Sun Lina , Suzuri Yoshiyuki , Yoshida Tsukasa 
Published: February 2023

AbstractElectrodeposition of copper(I) thiocyanate (CuSCN) thin films has been studied in a methanolic solution on variation of the precursor ratio to control morphological, crystallographic, and optoelectronic features of the product. While the one from a stoichiometric bath containing [Cu2+]: [SCN−] = 1:1 results in a randomly oriented crystalline β‐CuSCN, that from a Cu‐rich bath strongly orient the c‐axis perpendicular to the substrate, whereas that from SCN‐rich in parallel. The Cu‐rich film is dense and transparent, whereas the other two are hazy. All of them have an optical bandgap of about 3.6 eV as typically expected for β‐CuSCN, but their p‐type doping level varied to increase the work function from 5.31 to 5.66 eV on increasing the SCN− content, as found by photoelectron yield spectroscopy. This was caused by stabilization of Cu2+ acceptor level in the presence of excess SCN−, as also supported by an enhanced photoluminescence from the d‐d transition of Cu2+ state of such a film. Thus, electrodeposition has proven its usefulness to tailor‐tune optoelectronic properties on demand for device applications.
Assessing the effects of coral reef habitat and marine protected areas on threatened megafauna using aerial surveys
Authors: Heudier Mickael , Mouillot David , Mannocci Laura 
Published: February 2023

Abstract

Overfishing and habitat degradation are major threats to marine megafauna worldwide. Marine protected areas (MPAs) are effective spatial conservation tools for reducing anthropogenic pressures on threatened species but their benefits for megafauna are still debated. While the effects of MPAs on species abundances are widely reported, few studies have simultaneously investigated the confounding effect of habitat.
This study aimed at disentangling the effects of coral reef habitat and spatial protection on megafauna densities in a shallow lagoon partly covered by a no‐take MPA in New Caledonia (South‐west Pacific).
Twenty replicates of aerial‐video surveys (representing 17 h of videos) were conducted during a 5‐month period to estimate and map the densities of five megafauna taxa (dugongs, sea turtles, sharks, Dasyatidae rays and Myliobatidae rays). A permutational multivariate analysis of variance was then applied to assess and disentangle the effects of coral reef habitat obtained from high‐resolution satellite imagery and spatial protection on megafauna taxa densities.
The analysis revealed a significant effect of protection for sharks and Myliobatidae, with observed densities respectively 9 and 3 times higher inside the MPA compared with outside. The results also highlighted a significant combined effect of habitat and protection for dugongs and Dasyatidae, as well as a significant effect of habitat alone for Dasyatidae. In contrast, no significant effect of habitat or protection was detected for sea turtles.
In conclusion, this study revealed positive effects of protection (alone or combined with habitat) for four of the five studied megafauna taxa, confirming the effectiveness of the current MPA. Future studies should be conducted over broader spatial and temporal scales to examine whether detected effects hold beyond the surveyed period and area.
Knockdown of Dcr1 and Dcr2 limits the lethal effect of C‐factor in Chilo suppressalis
Authors: Yao Zhuotian , Jin Huihui , Li Changyan , Ma Weihua , Zhang Wei , Lin Yongjun 
Published: February 2023

AbstractDicer is a highly conserved ribonuclease in evolution. It belongs to the RNase III family and can specifically recognize and cleave double‐stranded RNA (dsRNA). In this study, the genome and transcriptome of Chilo suppressalis were analyzed, and it was found that there were two members in the Dicer family, named Dcr1 and Dcr2. The dsRNAs of Dcr1 and Dcr2 genes were synthesized and fed to C. suppressalis larvae. The C‐factor of C. suppressalis was selected as the marker gene. The results showed that both Dcr1 and Dcr2 genes were significantly knocked down. The larval mortality was significantly reduced by 43.50% (p < 0.05) after feeding on dsC‐factor and dsDcr1. The transcription levels of C‐factor genes were significantly increased by 33.95% (p < 0.05) and 32.94% (p < 0.05) when the larvae fed with dsDcr2 + dsC‐factor for 72 h and 96 h, respectively. Furthermore, the mortality was significantly decreased by 79% (p < 0.05) after feeding dsC‐factor and dsDcr2. These findings imply that Dcr1 can decrease the lethal effect of C‐factor gene but cannot affect its RNAi efficiency and Dcr2 can decrease the lethal effect of C‐factor gene by inhibiting RNAi efficiency.
Order in multi‐attribute product choice decisions: Evidence from discrete choice experiments combined with eye tracking
Authors: Zuschke Nick 
Published: February 2023

AbstractOver time, research on order effects during information searching and choice tasks has received thorough attention in marketing, psychology, and economics. When early information search influences choice in favor of that information, it is called primacy; the equivalent for later information search is called recency. However, research that disentangles primacy and recency effects during multi‐attribute product choice, as well as studies on the cognitive processes underlying primacy and recency effects are lacking. I address this gap with two choice‐based conjoint experiments combined with eye tracking and by means of multilevel mediation analysis. Consistent with my prediction that to counterbalance the impact of decision irrelevant information on choice through early information search by later information search is mentally too costly, I find that “spatial position” biases choice due to primacy rather than recency. This bias, however, is small. This suggests that for decision irrelevant information, the causal influence of attention on choice generalizes to more complex decisions, though with little impact. Consistent with my prediction that the level of information elaboration moderates the mediation process, increasing task motivation decreases the dominance of primacy.
Measuring what gets done: Using goal attainment scaling in a vocational counseling program for survivors of childhood cancer
Authors: Pole Jason D. , Williams Barb , Di Giuseppe Giancarlo , Guger Sharon , Stasiulis Elaine , Greenberg Mark L. , Spiegler Brenda J. , Edelstein Kim 
Published: February 2023

AbstractBackgroundChildhood cancer survivors face education and employment challenges due to physical, cognitive, and psychosocial effects of the disease and treatments, with few established programs to assist them. The objectives of this study were to describe the implementation of Goal Attainment Scaling (GAS) to evaluate an educational and vocational counseling program established for survivors of childhood cancer, and analyze patterns of program engagement and client outcomes, stratified by demographic and diagnostic characteristics.MethodsA population‐based retrospective cohort study of childhood cancer survivors who were engaged with the Pediatric Oncology Group of Ontario's School and Work Transitions Program (SWTP) between January 2015 and December 2018 was utilized. Survivors were followed from SWTP engagement until May 30, 2019 to capture goal attainment. Individual goals were summarized across various demographic, disease, and treatment strata.ResultsIn total, 470 childhood cancer survivors (median age = 17.9, 58% male) set 4,208 goals in the SWTP during the study period. The mean length of observation was 130.8 weeks (SD = 56.9). Overall, 68% of the goals were achieved. Eighty‐three percent of the goals related to further education. Clients diagnosed with a solid tumor set the most goals on average, followed by those with central nervous system tumors and leukemia/lymphoma.ConclusionsThe SWTP assists childhood cancer survivors in realizing their academic and vocational goals. Application of GAS in this setting is a feasible way to evaluate program outcomes. From the volume and breadth of the GAS goals set and achieved, the overall success of the SWTP appears strong.