bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ravulizumab demonstrates long-term efficacy, safety and favorable patient survival in patients with paroxysmal nocturnal hemoglobinuria
Authors: Kulasekararaj Austin , Brodsky Robert , Schrezenmeier Hubert , Griffin Morag , Röth Alexander , Piatek Caroline , Ogawa Masayo , Yu Ji , Patel Ami S. , Patel Yogesh , Notaro Rosario , Usuki Kensuke , Kulagin Alexander , Gualandro Sandra , Füreder Wolfgang , Peffault de Latour Regis , Szer Jeff , Lee Jong Wook 
Published: January 2025

Abstract
Ravulizumab is a second-generation complement component 5 (C5) inhibitor (C5i) approved for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) following positive results from two pivotal trials in patients with PNH originally naive to C5i treatment and eculizumab-experienced patients with PNH. In both trials, after the 26week primary evaluation period, all patients received ravulizumab for up to 6 years. To report ravulizumab treatment outcomes in patients with PNH originally naive to C5i treatment and eculizumab-experienced patients with PNH treated for up to 6 years. Originally C5i-naive (N = 244) and eculizumab-experienced (N = 191) patients with PNH continued ravulizumab treatment for up to 6 years. Major adverse vascular events (MAVEs; including thrombotic events [TEs]) and survival are reported, including a comparison of survival with untreated patients from the International PNH Registry. Laboratory parameters for intravascular hemolysis (IVH) are also described. For up to 6 years (1468.0 patient-years of exposure), ravulizumab provided durable control of terminal complement activity and IVH, resulting in a low incidence of MAVEs (including TEs) reported (MAVE rate: 0.7–1.4 per 100 patient-years) and, compared with untreated patients from the International PNH Registry, reduced the risk of mortality by five-fold. The few breakthrough IVH events reported (N = 122) were commonly associated with complement-amplifying conditions, and only two events (1.8%) were associated with suboptimal inhibition of C5 (i.e. serum free C5 ≥ 0.5 µg/mL). These results support the long-term use of ravulizumab as the first-line treatment of choice for patients with PNH. Trial registration details: NCT01374360; registered: October 29, 2004; NCT02946463; registered: October 27, 2016; NCT03056040; registered: June 05, 2017.
Maternal lipids in overweight and obesity: implications for pregnancy outcomes and offspring’s body composition
Authors: Albrecht Marie , Worthmann Anna , Heeren Jörg , Diemert Anke , Arck Petra Clara 
Published: January 2025

Abstract
Overweight and obesity (OWO) are linked to dyslipidemia and low-grade chronic inflammation, which is fueled by lipotoxicity and oxidative stress. In the context of pregnancy, maternal OWO has long been known to negatively impact on pregnancy outcomes and maternal health, as well as to imprint a higher risk for diseases in offspring later in life. Emerging research suggests that individual lipid metabolites, which collectively form the lipidome, may play a causal role in the pathogenesis of OWO-related diseases. This can be applied to the onset of pregnancy complications such as gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP), which in fact occur more frequently in women affected by OWO. In this review, we summarize current knowledge on maternal lipid metabolites in pregnancy and highlight associations between the maternal lipidome and the risk to develop GDM, HDP and childhood OWO. Emerging data underpin that dysregulations in maternal triglyceride, phospholipid and polyunsaturated fatty acid (PUFA) metabolism may play a role in modulating the risk for adverse pregnancy outcomes and childhood OWO, but it is yet premature to convert currently available insights into clinical guidelines. Well-designed large-scale lipidomic studies, combined with translational approaches including animal models of obesity, will likely facilitate the recognition of underling pathways of OWO-related pregnancy complications and child’s health outcomes, based on which clinical guidelines and recommendations can be updated.
Baseline PSMA PET/CT parameters predict overall survival and treatment response in metastatic castration-resistant prostate cancer patients
Authors: Kleiburg Fleur , de Geus-Oei Lioe-Fee , Spijkerman Romy , Noortman Wyanne A. , van Velden Floris H. P. , Manohar Srirang , Smit Frits , Toonen Frank A. J. , Luelmo Saskia A. C. , van der Hulle Tom , Heijmen Linda 
Published: January 2025

Abstract

Objective
Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease with varying survival outcomes. This study investigated whether baseline PSMA PET/CT parameters are associated with survival and treatment response.

Methods
Sixty mCRPC patients underwent [18F]PSMA-1007 PET/CT before treatment with androgen receptor-targeted agents (ARTAs) or chemotherapy. Intensity-based parameters, volumetric parameters, metastatic sites and DmaxVox (distance between the two outermost voxels) from baseline PSMA PET/CT were collected, as well as age, Gleason score and laboratory parameters. Cox regression analysis evaluated their prognostic value for overall survival (OS). Additionally, a preliminary lesion-level analysis was done (n = 241 lesions) with lesion location and twelve radiomic features selected from previous literature. Logistic regression evaluated their association with PSMA PET/CT-based lesion progression after 3–4 months of treatment.

Results
Total tumour volume (PSMA-TV) (HR = 1.41 per doubling [1.17–1.70]), total lesion uptake (TL-PSMA) (HR = 1.40 per doubling [1.16–1.69]) and DmaxVox (HR = 1.31 per 10 cm increase [1.07–1.62]) were prognostic for OS, each independent of baseline PSA level (HR = 0.82 per doubling [0.68–0.98]), haemoglobin level (HR = 0.68 per mmol/L increase [0.49–0.95]) and line of treatment. On lesion-level, location (prostate vs bone OR = 0.23 [0.06–0.83]) and SUVmean (OR = 1.72 per doubling [1.08–2.75]) were independent prognostic markers for lesion progression, morphological and texture-based radiomic features were not.

Conclusion
Baseline PSMA PET/CT scans have prognostic value in mCRPC patients and can potentially aid in treatment decision-making. DmaxVox can serve as a simpler alternative to PSMA-TV when automated segmentation software is not available. When combined with PSMA-TV, lower PSA levels indicated worse OS, which may be a marker of tumour dedifferentiation. Further research is needed to validate these models in larger patient cohorts.

Key Points

Question

mCRPC is a highly heterogeneous disease, requiring good prognostic markers.

Findings

PSMA-TV was the best independent prognostic marker for OS; maximum distance between lesions (DmaxVox) can be used as a simpler alternative.

Clinical relevance

Baseline PSMA PET/CT parameters representing tumour burden were independently associated with OS in mCRPC patients, providing prognostic insights for clinical decision-making. Although PSMA-TV was the best prognostic marker, DmaxVox can serve as an easier to obtain alternative.
Temporal variation in nutritional status and preoperative anemia among patients with retroperitoneal soft tissue sarcoma: a retrospective longitudinal cohort study
Authors: Willis Franziska , Trunk Anna-Marlen , Musa Julian , Harnoss Jonathan M. , Strowitzki Moritz J. , Engerer Cosima , Harnoss Julian-C. , Al-Saeedi Mohammed , Büchler Markus W. , Schneider Martin 
Published: January 2025

Abstract

Purpose
Optimal management of retroperitoneal soft tissue sarcoma (RPS) often requires extensive tumor resections, frequently involving gastrointestinal organs. The impact of these procedures on the nutritional status and hemoglobin (Hb) levels of RPS patients remain unexplored. In this study, we aimed to evaluate preoperative nutritional status as well as the prevalence of anemia in RPS patients, and to investigate longitudinal changes throughout the disease course in order to identify potential strategies for prehabilitation.

Materials and methods
Patients undergoing resection of primary and recurrent RPS at Heidelberg University Hospital were retrospectively analyzed. Changes in nutritional parameters and Hb levels throughout the disease course were analyzed using hierarchical linear regression models. Multivariable Cox regression analyses were performed to identify independent predictors of overall survival. Subgroup analyses were conducted for primary tumors, first, second and third recurrences.

Results
Amongst 370 patients analyzed, comprising 219 with primary disease, we observed neither a significant prevalence of preoperative malnutrition nor notable changes in BMI or serum albumin levels throughout the disease course. Preoperative anemia affected up to 40% of RPS patients, and Hb levels significantly decreased over the course of the disease (p = 0.022), particularly in correlation with the number of tumor resections performed (p = 0.010). Low preoperative Hb levels were associated with increased 30-day mortality and they were identified as an independent prognostic factor for shorter overall survival in primary RPS as well as in second and third recurrences.

Conclusion
Anemia screening should be performed preoperatively and during regular follow-ups to enable early-on therapy, thus potentially improving patient outcomes in RPS.
Volumetric Measurements of Mean Velocity Vector and Reynolds Stress Tensor for CFD Validation: Magnetic Resonance Velocimetry in a Nuclear Fuel Assembly Model with Mixing Grids
Authors: John Kristine , Romig Swantje , Rehm Markus , Hadžić Hidajet , Pohl Peter , Grundmann Sven , Bruschewski Martin 
Published: January 2025

Abstract
Experimental studies in industrial-relevant geometries are of great value for validating computational fluid dynamics (CFD). This study provides such data using Magnetic Resonance Velocimetry (MRV) in a replica of the single-phase and isothermal OECD/NEA-KAERI rod bundle benchmark exercise based on the MATiS-H test facility at the Korea Atomic Energy Research Institute (KAERI). The geometry is a 5 × 5 nuclear fuel assembly model of a pressurized water reactor with a split-type mixing grid inducing a swirling flow in each sub-channel. The Reynolds number based on the hydraulic diameter is 50,250. Recent studies demonstrated that MRV enables a comprehensive validation of CFD results in industrial-relevant test cases by providing time-averaged, three-dimensional measurement data from complex opaque structures. Nevertheless, there was still some potential left to improve the accuracy of the measurement. This study uses a newly developed MRV method to accurately measure the mean velocity vectors and the Reynolds stress tensor in three dimensions. The measurement volume reaches from shortly upstream to 10 times the hydraulic diameter downstream of the mixing grid. The estimated mean measurement uncertainty of the velocity data is 1.9% based on the bulk velocity of 1.72 m/s. In the case of the Reynolds stress data, the estimated mean uncertainty for each component is between 0.7 and 1.8% based on the square of the bulk velocity. The comparison to previously published Laser Doppler velocimetry measurements confirms the high accuracy of the reported 3D MRV data. The study includes a detailed description of the technique and boundary conditions. The measurement data is available to interested parties upon request.
Intracardiac or transesophageal echocardiography for left atrial appendage occlusion: an updated systematic review and meta-analysis
Authors: Beneki Eirini , Dimitriadis Kyriakos , Theofilis Panagiotis , Pyrpyris Nikolaos , Iliakis Panayiotis , Kalompatsou Argyro , Kostakis Panagiotis , Koukos Markos , Soulaidopoulos Stergios , Tzimas Georgios , Tsioufis Konstantinos , Lancellotti Patrizio , Aggeli Constantina 
Published: January 2025

Abstract

Background
Intracardiac echocardiography (ICE) appears to be a potential alternative for percutaneous left atrial appendage occlusion (LAAO) to transesophageal echocardiography (TEE). Thus, a meta-analysis was performed comparing ICE vs. TEE for LAAO guidance.

Methods
A comprehensive literature search was performed using MEDLINE, Scopus and Web of Science electronic databases from their inception to November 2023.

Results
18 studies (124,230 patients) were included. Technical success was higher in ICE- compared to TEE-guidance (OR: 1.36, 95% CI 1.14 to 1.63, p = 0.006) and fewer devices employed (SMD: -0.22, 95% CI -0.43 to -0.01, p = 0.04, I2 = 62%). ICE guidance related with more pericardial effusion/tamponade and iatrogenic residual shunts (logRR: 0.62, 95% CI 0.36 to 0.89, p < 0.001 and RR: 1.53, 95% CI 1.12 to 2.09, p = 0.02, I2 = 1%, respectively). More vascular complications were noted in ICE group (logRR: 0.45, 95% CI 0.11 to 0.78, p = 0.009).

Conclusion
ICE-guided imaging is an effective alternative to TEE in LAAO, as it shows better efficacy than TEE, considering technical success. However, the higher rates of adverse events should be carefully considered.
Understanding Treatment Pathways in Cognitive-Behavioral and Experiential Therapies for Social Anxiety: Evidence from a Randomized Controlled Trial
Authors: Abeditehrani Hanieh , Dijk Corine , Arntz Arnoud 
Published: January 2025

Abstract

Background
Cognitive behavioral group therapy (CBGT), psychodrama (PD), and their integration (CBPT) are effective in treating social anxiety disorder (SAD). However, the processes underlying their effectiveness are not fully understood. This study investigated whether changes in cognitive biases and reductions in avoidance behaviours mediated treatment effects. For PD and CBPT we additionally hypothesized a mediation effect of increased spontaneity.

Methods
Using data of 116 SAD participants in a randomized controlled trial (RCT) with four conditions (waitlist, CBGT, PD, CBPT), we examined mediators of treatment effect. Mediation analyses with bootstrapping tested the pathways trough which active treatments (compared to waitlist) affected post-treatment effects.

Results
The analyses indicated that perceived cost of negative social events mediated CBGT and CBPT outcomes, while perceived probability mediated PD and CBPT. Spontaneity did not mediate effects in of any treatment, while avoidance mediated outcomes across all interventions. Analysis using post-treatment mediators were all significant and showed no treatment specificity.

Conclusions
Underscoring its critical role in treating SAD, avoidance emerged as a consistent mediator of treatment effects. In contrast, cognitive biases were treatment-specific: reduced costs mediated outcomes in interventions with cognitive techniques, while reduced likelihood mediated outcomes in experiential interventions.
Patient-Therapist Congruence Regarding Therapy Progress Perceptions in Psychotherapy for Persistent Somatic Symptoms
Authors: Daehler Sarah , Lutz Wolfgang , Probst Thomas , Rief Winfried , Rubel Julian , Schwartz Sarah , Kleinstaeuber Maria 
Published: January 2025

Abstract

Background
This study expands the understanding of congruence, or the level of agreement, between therapists and patients regarding therapy progress perception during psychotherapy for distressing persistent somatic symptoms (PSS).

Method
We completed a Grid Sequence Analysis of 174 patient-therapist dyads completing cognitive behavior therapy (CBT) to explore congruence patterns regarding therapy progress perceptions, assess baseline characteristic associations with congruence patterns, and investigate whether these patterns are associated with treatment outcomes.

Results
A notable majority of dyads (91.4%) were able to reach strong positive congruence by the end of treatment. No baseline characteristics were associated with congruence patterns, except for baseline depression, which was related to a congruence pattern in which the patient underestimated therapeutic progress relative to their therapist. Strong positive congruence was associated with decreased symptom severity at the end of treatment, but no association with disability was found.

Conclusion
Overall, it appears that congruence is an important factor in the treatment of PSS. Our results demonstrate that patients can develop strong positive congruence with their therapists regardless of what baseline characteristics they present with. Thus, therapists should aim to develop positive congruence with their patients early in treatment.
Yield determinants of Kappaphycus alvarezii seaweed in South Sulawesi, Indonesia
Authors: van Oort P. A. J. , Julianto B. , Latama G. , Siradjuddin I. , Rukminasari N. , Walyandra Z. Z. , Ibrahim I. A. , Verhagen A. , van der Werf A. K. 
Published: January 2025

Abstract
There has been limited systematic monitoring of seaweed growth with simultaneous measurement of important yield determinants. This study reports on Kappaphycus alvarezii (Cottonii) seaweed experiments in South Sulawesi, Indonesia. The first (June – Oct 2023) experiment showed lower yields for the lowest seedling weight and similar yields for the medium/high seedling weight. During this period, seaweed losses from lines (empty ties), ice-ice disease and fouling by epiphytes increased. The second experiment (March – July 2024) showed high yields for the traditional longline and low yields with tube-nets and cages, due to fouling by epiphytes and mud. Yields did not differ systematically between villages and did not differ systematically between nearshore and further offshore. Yields were highest for planting in March and lowest for planting in August. Stronger winds and rougher sea towards October were shown to be an important yield determinant, but not the only one. During the March-October period losses from lines increased, pressure from the ice-ice disease increased, fouling by mud and epiphytes increased, temperatures decreased and windspeed increased. Yields in the March-October cultivation cycles were determined by a combination of the effects of these five yield determinants. To our best knowledge the current study is the first to study this full range of possible yield determinants and to simultaneously monitor for longer period (five cycles, with bi-weekly sampling) both seaweed biomass and yield determinants.
PolyCard: A learned cardinality estimator for intersection queries on spatial polygons
Authors: Ji Yuchen , Amagata Daichi , Sasaki Yuya , Hara Takahiro 
Published: January 2025

Abstract
How can we estimate the result size for a given query on complex spatial objects like polygons? Estimating a query’s result size, also known as the cardinality estimation, plays a significant role in query scheduling and optimization. Accurate and fast cardinality estimation substantially improves query efficiency. Existing compatible solutions, mainly histogram-based, deal with polygons as their minimal bounding rectangles for easier processing, which leads to inaccurate estimation. To address this issue, we present PolyCard, a learned cardinality estimator for intersection queries on spatial polygons. We successfully apply learning techniques to spatial polygons with variable sizes. PolyCard has the following properties. (i) Accurate: PolyCard improves 30% accuracy compared with existing solutions, (ii) Fast: PolyCard takes only 4 microseconds for an estimation, and (iii) Stable: PolyCard is robust against datasets and queries of different cardinalities. Our experiments on four real-world datasets of millions of polygons demonstrate the efficiency and effectiveness of PolyCard.
Identification of Components of the Sex Pheromone of the kōwhai Moth, Uresiphita Polygonalis Maorialis, a New Zealand Native Crambid
Authors: El-Sayed Ashraf M. , Gibb A. R. 
Published: January 2025

Abstract
The identification of sex pheromones in native New Zealand moths has been limited, largely due to their minimal pest impact on agricultural ecosystems. The kōwhai moth, Uresiphita polygonalis maorialis, a native crambid, is known for its herbivory on Sophora spp. and Lupinus arboreus leaves. Understanding the chemical ecology of this species is essential for studying its behavior, population dynamics, and ecological interactions. In this study, the female sex pheromone of U. polygonalis maorialis was analyzed using coupled gas chromatography-electroantennogram detection (GC-EAD). This approach identified four antennally active compounds in the female gland extracts. Subsequent gas chromatography-mass spectrometry (GC-MS) and chemical derivatization revealed these compounds to be tetradecyl acetate (14:Ac), (E)-11-tetradecenyl acetate (E11-14:Ac), (Z)-11-tetradecenyl acetate (Z11-14:Ac), and (Z)-11-hexadecenyl acetate (Z11-16:Ac). Field trapping experiments evaluated various combinations of these four EAD-active compounds and (E)-11-hexadecenyl acetate (E11-16:Ac). Results indicated that traps baited with blends containing E11-14:Ac, Z11-14:Ac, and Z11-16:Ac captured significantly more males compared to unbaited delta traps. A blend ratio of 144:84:72 µg (E11-14:Ac: Z11-14:Ac: Z11-16:Ac) proved the most effective, capturing the highest number of males. Male captures were recorded from late November to late February, peaking in late December, suggesting a univoltine population in Canterbury. Among the three tested doses, the 300 µg and 1000 µg doses of the three-component blend were the most effective. The identification of the sex pheromone components of U. polygonalis maorialis provides a valuable tool for monitoring this species, contributing to a deeper understanding of its population densities and distribution within its native range. It also offers insights into the evolutionary development of pheromone communication within the genus, shedding light on species divergence and adaptation.
Beyond “Dead Words”: Enhancing Documentation Practices for Domestic Violence-Informed Work
Authors: Isobe Jasmin , Laing Lesley , Kertesz Margaret , Humphreys Cathy 
Published: January 2025

Abstract

Purpose
Domestic violence-informed documentation practices across health and human services were explored as an aspect of a wider action research project in New South Wales, Australia. In health and human service responses to families living at the intersection of domestic violence, substance misuse and mental ill-health, practitioners navigate the complexities of collaborative and integrated work to address violence and abuse. Documentation is an aspect of practice where ethical, quality and safety issues arise, impacting individuals, organizations, and service sectors.

Methods
Senior practitioners from specialist domestic violence, substance use, mental health and child protection services participated in a series of Communities of Practice to explore integrated and collaborative practice using the Safe & Together™ Model approach to working with families impacted by domestic violence and abuse. Documentary practices were explored as an important aspect of the wider research project, and ethnographic notes from Community of Practice and reflective focus groups were thematically analyzed.

Results
Four key themes regarding domestic violence-informed documentation practices were highlighted in the analysis: recognizing the power of documentation; maintaining an all-of-family focus; focussing on patterns and context; and the importance of language that emphasizes behavioral specificity. Taken together, these themes speak to the powerful role played by domestic violence-informed documentation for clients accessing services, as well as to the opportunity for practice-changing work through documentation that diverse practitioners can take up when working with families and with each other.

Conclusion
This paper contributes to a growing body of practice-led knowledge building and provides an in-depth examination of domestic violence-informed documentation practices from the perspectives of practitioners working at the intersections of domestic violence, substance use, mental health and child protection issues across health and human services. It highlights the complex and empowering opportunities that attention to language and documentation holds and emphasizes the need for further research exploration and capacity building for domestic violence-informed practice.