bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Inhibitory Effect of Human Placenta Extract (Laennec ® ) on Atopic Dermatitis-Like Skin Disease In Vivo and In Vitro
Authors: Jeong Kyeongsoo , Jeon So-Hyun , Jin Hui , Im Minju , Kim Jae-Won 
Published: July 2023

Abstract
Atopic dermatitis (AD) is an allergic inflammatory skin disease accompanied by severe itching and eczema. Human placenta extract (PE), used for treatment of conditions related to hepatic function, possess anti-inflammatory and antiviral properties. In this study, we investigated the efficacy of PE against AD in a 2,4-dinitrochlorobenzene (DNCB)-induced AD mouse model, and in tumor necrosis factor (TNF)-α/interferon (IFN)-γ-stimulated human keratinocytes (HaCaT) and immunized splenocytes. We confirmed that subcutaneous administration of PE (200 or 400 µL, twice a week) improved AD skin lesions and reduced the spleen index in mice. In addition, the expression levels of immune-related and proinflammatory factors were suppressed in serum and skin tissue. These results were consistent with the tendency observed in HaCaT cells and splenocytes. Intriguingly, human-derived PE had no side effects, such as loss of muscle mass, compared to corticosteroid, which was used as a positive control. Taken together, our results demonstrate that PE effectively inhibits the development of AD and might be a potentially useful therapeutic agent for AD-like skin disease.
AI vs Humans: The Future of Academic Review in Public Administration
Authors: Salah Mohammed , Abdelfattah Fadi , Alhalbusi Hussam 
Published: July 2023

Abstract
In the ever-evolving landscape of academia, artificial intelligence (AI) presents promising opportunities for enhancing the academic review process. In this study, we evaluated the proficiency of Bard and GPT-4, two of the most advanced AI models, in conducting academic reviews. Bard and GPT-4 were compared to human reviewers, highlighting their capabilities and potential areas for improvement. Through a mixed-methods approach of quantitative scoring and qualitative thematic analysis, we observed a consistent performance of the AI models surpassing human reviewers in comprehensibility, clarity of review, the relevance of feedback, and accuracy of technical assessments. Qualitative analysis revealed nuanced proficiency in evaluating structure, readability, argumentation, narrative coherence, attention to detail, data analysis, and implications assessment. While Bard exhibited exemplary performance in basic comprehension and feedback relevance, GPT-4 stood out in detailed analysis, showcasing impressive attention to minor discrepancies and meticulous scrutiny. The results underscore the potential of AI as an invaluable tool in the academic review process, capable of complementing human reviewers to improve the quality, efficiency, and effectiveness of reviews. However, we also identified areas where human reviewers excel, particularly in understanding complex academic language and intricate logical progressions, offering crucial insights for future AI model training and development.
The impact of different conservation strategies on the gut microbiome and metabolome of the threatened wildlife: an observation from golden snub-nosed monkey
Authors: Zhang Du , Hu Qi , Zhou Yunyun , Yu Huiliang , Cong Wei , Cheng Minghao , Wang Junwen , Liu Xueduan , Zou Kai , Long Shuizhi , Zhao Chongnan , Jiang Jun , Gao Fei , Zhang Yuguang 
Published: July 2023

Abstract
Human conservation efforts have pros and cons for endangered animals. Metagenomic analysis of the gut microbiome provides valuable insights and tools for wildlife conservation. However, most studies only focus on changes in microbial species and potential functional genes, leaving out the assembly mechanisms and metabolic activities of wildlife gut microbiome. Herein, we investigated the gut microbiome of golden snub-nosed monkeys under varied conservation strategies (wild, captive, and food provision) using metagenome and metabolome analysis. We found that the conserved monkeys had more non-redundant genes, distinct community diversities, and less stable gut microbiota. Source-tracking analysis showed captive group has fewer wild-sourced microbes than food provision group. The captive group had more habitat specialists with narrower niche breadth compared to the provision/wild counterparts. Besides, captive group's microbiota governed by deterministic processes more than provisioned/wild groups. Procrustes analysis revealed changes in antibiotic resistance genes and virulence factors linked to mobile genetic elements in conserved monkeys. Notably, gut microbiota and metabolomic dataset had significant co-variation and clear separation among the wild, captive and food provision groups. Weighted correlation network analysis identified co-varying modules of microbiota and metabolites with opposite variation trends between the wild and conserved animals, specifically linked to co-metabolism pathways associated with essential amino acids. This study provides new insights into the structural features, assembly mechanisms, community functions, and microbiota-metabolome associations of wildlife gut microbiome under different conservation strategies and have significant implications for advancing sustainable conservation practices.
Gestufte digitale Lernhilfen als Professionalisierungskonzept für inklusiven Naturwissenschaftsunterricht
Authors: Schilling Navina , Goltz Jonas , Koisser Sebastian , Demmer Christine , Löser Jessica , Werning Rolf 
Published: July 2023

Schule steht vor umfassenden Veränderungen, wenn sie die Entwicklungsanlässe von Digitalisierung und Inklusion umzusetzen versucht. Beide gehen für Schule mit großen Herausforderungen, aber auch Chancen einher. Anknüpfend an vorliegende Befunde im Schnittfeld von Digitalisierung und Inklusion wird im vorliegenden Artikel das Projekt DiLernProfis vorgestellt, das sich mit der Nutzung von gestuften digitalen Lernhilfen in Form von Tablet-Apps beim Experimentieren im inklusiven Naturwissenschaftsunterricht der Sekundarstufe I befasst. Die Lernhilfe liegt in Form einer im Projekt entwickelten App für Tablets vor, die den Schüler*innen ein selbstständiges Bearbeiten von Aufgaben ermöglichen soll. Es werden erste Ergebnisse aus dem qualitativ empirischen Teil des Projekts DiLernProfis vorgestellt (teilnehmende Unterrichtsbeobachtungen und Interviews mit Lehrkräften) und deren Bedeutung für die Entwicklung eines Fortbildungskonzeptes diskutiert. Die Ergebnisse zeigen eine als nicht optimal wahrgenommene Passung zwischen den gestuften digitalen Lernhilfen und den Lernvoraussetzungen der heterogenen Lerngruppen sowie ein mögliches Stigmatisierungspotenzial, das die Nutzung der Lernhilfe birgt.

Abstract
Schools are facing extensive changes as they attempt to implement the prompts for development brought about by digitization and inclusion. For schools, both areas are accompanied by major challenges, especially when they are related to each other, but they are equally accompanied by opportunities. Building on existing findings at the intersection of digitization and inclusion, this article presents the DiLernProfis project, which focuses on the use of staged digital learning aids in the form of tablet apps that can be used for experimentation in inclusive science classes at the lower secondary level. The learning aid, i.e. the tablet app has been developed in the project and is intended to enable students to work on tasks independently. In the following, we will present first findings from the qualitative empirical part of the DiLernProfis project (participatory classroom observations and interviews with teachers) and discuss their significance for the development of an advanced training concept. The results show a perceived mismatch between the staged digital learning aids and the learning requirements of the heterogeneous student groups as well as a potential for stigmatization that the use of the learning aid might entail.
Spatial distribution and water quality index of Lahore Canal, Pakistan
Authors: Jalees Muhammad Irfan , Irfan Iffat , Ali Asif , Batool Madeeha 
Published: July 2023

Abstract

The Lahore Canal (LC) in Lahore city of Pakistan, with the discharge of 402 cusecs, runs along the city's centre. With rapid urbanization and population growth, the LC water is deteriorating. This study determined the water quality index and spatial distribution of pollutants. Three months of sampling from six separate locations were performed. Water quality parameters were analysed. The results indicated that pH, solids, turbidity, hardness, alkalinity, and chlorides were within guidelines, but DO BOD and nitrogen were beyond guidelines. Moderate BOD values (2.24–8.06 mg/L) and low DO values (0.13–3.56 mg/L) indicated a low oxygen environment. Heavy metal concentration was as follows: Fe &gt; Pb &gt; Cr &gt; Cu. The Pearson correlation coefficient indicated ± poor to moderate (0.3–0.7) correlation. The ANOVA result supported the alternative hypothesis, i.e., the pollutants originated from the same source. Principal component analysis and cluster analysis showed three primary sources for the different pollutants based on loading of variance and Euclidean distance, respectively. The WQI of LC at all locations was above 300, indicating that LC water is not suitable for any usage. The spatial distribution of parameters indicated the effects of urbanization and commercialization (small household industries) at Location-4. The poor water quality of LC needs immediate government attention.
Performance evaluation of pilot-scale reverse osmosis spiral wound membrane for water desalination systems
Authors: Allam Mohamed , Soussa Hoda , Elalfy Ezzat 
Published: July 2023

Abstract
The increasing scarcity of potable water increases the demand for non-conventional potable water resources such as desalination. Experiments are carried out using a pilot-scale device of the desalination process for three configurations of membrane allocation inside the pressure vessel. Configuration (A) is one pressure vessel containing one spiral wound membrane (SWM), (B) is four pressure vessels each containing one SWM connected in parallel, and (C) is one pressure vessel containing four membranes connected in parallel. The effect of applied pressure, temperature, and water salinity is studied. Moreover, a mathematical model using ANSYS Fluent was developed and verified using the experimental data. The mathematical model is applied to an idealized case of an actual desalination plant. The main findings are (1) configurations (B) and (C) accomplished higher permeate discharge comparing to (A) by an average percentage of 60 and 50, respectively, while (C) has the lowest output salinity by 30% from configuration (A). (2) The mathematical model is found to reduce the operating pressure of the plant by 8%.
Determinants of transitions in drinking water service systems in developing economies: a case study of Uganda
Authors: Sempewo Jotham Ivan , Kayaga Sam 
Published: July 2023

Abstract
Limited research has been undertaken on significant factors associated with transitions between drinking water supply systems (DWSS) ladders. In this paper, we applied panel ordered logistic multinomial logistic regression models to seven datasets of the Uganda Demographic and Health Survey (1988–2021), with the SDG6 categorical levels of DWSS (unimproved, improved and piped into dwelling) as transition levels, and various socio-economic and demographic characteristics as covariates. Sex and education level of household head, toilet facility, electricity access, size of agricultural land and wealth index are significant factors. The main implication is the need to address socio-economic disparities in developing economies.
Water footprint assessment and its importance in Indian context: a meta-review
Authors: Mehla Mukesh Kumar , Kothari Mahesh , Singh Pardeep Kumar , Bhakar Sita Ram , Yadav Kamal Kishore 
Published: July 2023

Abstract

With the increasing population and per capita demand for freshwater, the burden of natural resources has increased many folds. Indian agriculture is still largely dependent on conventional methods of crop production that are mainly inefficient. Water security is essential for social and economic development, having an indispensable role in enhancing health, well-being, and economic progress, particularly in a developing country like India. Water footprint (WF) is an important indicator that helps ascertain the direct and indirect use of water in any process. WF modeling in agriculture enables us to pinpoint the impacts and limitations of the current crop production system. Assessing vulnerabilities across various regions and time helps us prepare actions to improve water productivity and promote sustainable water use. There is considerable spatial variability in blue, green, and gray WF among the different states of India due to their varied climate, soil, and topographic characteristics. WF assessment is critical for developing water allocation strategies, planning water trade, making policies, and implementing remedial measures. This paper describes the significance of WF and its proper management for sustainable crop production in India.
Composición de la regeneración natural arbórea de un bosque de galería en el Estado de Goiás, Brasil
Authors: Imaña-Encinas José 
Published: July 2023

Se analizó la vegetación natural de una hectárea en el bosque de galería del río de los Macacos localizado en el municipio de Santo Antônio do Descoberto en el estado de Goiás (Brasil). La hectárea analizada fue la suma de diez parcelas discontinuas de 1000 m2 cada una, establecidas al azar. En cada una de estas parcelas fueron registrados todos los individuos de regeneración natural arbórea con DAP (Diámetro a la Altura del Pecho, 1,30 m del suelo) menor o igual a 5 cm. En total fueron contabilizados 2361 individuos de regeneración arbórea de los cuales 448 presentaron un DAP máximo de 5 cm. Fueron identificadas 73 especies que correspondieron a 35 familias botánicas, entre ellas resalta la familia Fabaceae que reportó siete especies. Las especies que presentaron más de cien individuos fueron Cabralea canjerana (Vell.) Mart. (210), Cheiloclinium cognatum (Miers) A.C. Sm. (114), Virola sebifera Aubl. (104) y Aspidosperma cylindrocarpon Müll. Arg. (100).
Recent Advances on PKM2 Inhibitors and Activators in Cancer
Applications
Authors: Chen Peng , Lou Liang , Sharma Bigyan , Li Mengchu , Xie Chengliang , Yang Fen , Wu Yihang , Xiao Qicai , Gao Liqian 
Published: July 2023

Abstract:
Metabolic reprogramming of cells, from the normal mode of glucose
metabolism named glycolysis, is a pivotal characteristic of impending cancerous cells.
Pyruvate kinase M2 (PKM2), an important enzyme that catalyzes the final rate-limiting
stage during glycolysis, is highly expressed in numerous types of tumors and aids in development
of favorable conditions for the survival of tumor cells. Increasing evidence
has suggested that PKM2 is one of promising targets for innovative drug discovery, especially
for the developments of antitumor therapeutics. Herein, we systematically summarize
the recent advancement on PKM2 modulators including inhibitors and activators
in cancer applications. We also discussed the classifications of pyruvate kinases in mammals
and the biological functions of PKM2 in this review. We do hope that this review
would provide a comprehensive understanding of the current research on PKM2 modulators,
which may benefit the development of more potent PKM2-related drug candidates
to treat PKM2-associated diseases including cancers in future.
Titanium (IV) μ-Oxo Complex Supported by Phenoxyimine Ligand: Synthesis, Crystal Structure Characterisation, DFT and
Molecular Docking Studies
Authors: Sajjan Vinodkumar P. , Gurubasavaraj Prabhuodeyara M. , Pujari Vikram , Inamdar Sanjeev R. , Mukerjee Nobendu 
Published: July 2023

Background:
Most of the transition elements in the 3d series (first row transition metals) have
been discovered to be extremely significant and practical in biological systems. Naturally, many of the
enzymes that are present in the human body system act as catalysts for biological processes and are made
of coordination compounds or complexes.

Objective:
The complex has been characterised by various spectroscopic and analytic techniques. A suitable crystal analysed by X-ray diffraction establishes the formation of a stable binuclear µ-oxo-complex
with a hexacoordinate titanium centre.

Methods:
A new crystalline complex [Ti{La}] has been synthesised in the reaction of titanium butoxide
with a phenoxyimine ligand in a 1:1 stoichiometry in toluene at room temperature under a nitrogen atmosphere. The newly synthesised Ti complex has undergone density functional theory and docking study.

Results:
The crystal shows a monoclinic system with space group C 1 2/c 1. X-ray crystal structure analysis reveals that this complex has a rhomboidal Ti-O-Ti core and exhibits a C2 symmetric conformation
with distorted octahedral geometry. Density Functional Theory (DFT) calculations giving insights into the
frontier orbitals and mulliken charge analysis, which showed good correlation with the experimental findings. Additionally, in silico molecular docking of ligand and complex was carried out against the HER2
inhibitor kinase.

Conclusion:
This complex exhibits a higher binding energy of ΔGb = -19.7 kcal/mol with the active
pocket of HER2 (PDB:7JXH) than the ligand ΔGb = -8.5 kcal/mol.
Identification of Cancer Stem Cell-related Gene by Single-cell and Machine
Learning Predicts Immune Status, Chemotherapy Drug, and Prognosis
in Lung Adenocarcinoma
Authors: Yang Chengcheng , Zhang Jinna , Xie Jintao , Li Lu , Zhao Xinyu , Liu Jinshuang , Wang Xinyan 
Published: July 2023

Aim:
This study aimed to identify the molecular type and prognostic model of lung adenocarcinoma
(LUAD) based on cancer stem cell-related genes. Studies have shown that cancer stem cells
(CSC) are involved in the development, recurrence, metastasis, and drug resistance of tumors.

Method:
The clinical information and RNA-seq of LUAD were obtained from the TCGA database.
scRNA dataset GSE131907 and 5 GSE datasets were downloaded from the GEO database. Molecular
subtypes were identified by ConsensusClusterPlus. A CSC-related prognostic signature was then constructed
via univariate Cox and LASSO Cox-regression analysis.

Result:
A scRNA-seq GSE131907 dataset was employed to obtain 11 cell clusters, among which, 173
differentially expressed genes in CSC were identified. Moreover, the CSC score and mRNAsi were higher
in tumor samples. 18 of 173 genes were survival time-associated genes in both the TCGA-LUDA dataset
and the GSE dataset. Next, two molecular subtypes (namely, CSC1 and CSC2) were identified based on
18 survival-related CSC genes with distinct immune profiles and noticeably different prognoses as well as
differences in the sensitivity of chemotherapy drugs. 8 genes were used to build a prognostic model in the
TCGA-LUAD dataset. High-risk patients faced worse survival than those with a low risk. The robust
predictive ability of the risk score was validated by the time-dependent ROC curve revealed as well as the
GSE dataset. TIDE analysis showed a higher sensitivity of patients in the low group to immunotherapy.

Conclusion:
This study has revealed the effect of CSC on the heterogeneity of LUAD, and created an 8
genes prognosis model that can be potentially valuable for predicting the prognosis of LUAD and response
to immunotherapy.
The Impact of COVID-19 Confinement on Reading Behavior
Authors: Alomari Mahmoud A. , Khabour Omar F. , Alzoubi Karem H. , Aburub Aseel 
Published: July 2023

Background:
The COVID-19 pandemic was detrimental to lifestyle and behavior. In this investigation, changes in reading habits during the pandemic were examined.

Methods:
The study is cross-sectional and survey-based. 1844 individuals completed an online survey about sociodemographic and reading habits during COVID-19. Multinomial logistic regression was used to examine the relationship between the study variables.

Results:
Most of the participants were active readers (71.5%-83.2%). Fewer (13.8-18.0%) reported a decrease in reading, while about half reported a no change, and 1/3rd reported an increase. Changes in reading habits were related to age, education, job type, and income.

Conclusion:
About half of the participants during the pandemic reported a change in reading habits. Interventions to further enhance reading among people during the pandemic might help ameliorate the negative impacts of the pandemic.
Safety and Efficacy of Imatinib, Nilotinib, and Artesunate in COVID-19
Patients: A Systematic Review of Current Evidence
Authors: Ghavimehr Ehsan , Zand Ali , SeyedAlinaghi Seyed Ahmad , Karimi Amirali , Zaferani Arani Hamid , Mirzapour Pegah , Pashaei Zahra , Mehraeen Esmaeil , Dadras Omid 
Published: July 2023

Introduction:
There is a need for better treatment options against COVID-19. This systematic review aimed to assess the safety and efficacy of imatinib and nilotinib, two tyrosine kinase inhibitors (TKIs), as well as artesunate (an anti-malarial agent), whose multilayer activ-ities against SARS, MERS, and SARS-CoV-2 pathogenesis have been suggested in laboratory and observational studies.

Methods:
A comprehensive search strategy targeting relevant literature on PubMed, Scopus, and Web of Science online databases was constructed. The retrieved records were reviewed and screened by title/abstract and full text with eligibility criteria, and the most pertinent articles were included in the final qualitative synthesis. This review adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to ensure the reliability of the results.

Results:
This systematic review assessed the safety and applicability of imatinib, nilotinib, and artesunate in COVID-19 patients. The results showed not only possible anti-COVID-19 effects but also acceptable safety for both generic users with comorbidities with COVID-19 and off-label use in other COVID-19 patients. Promising results were also reported enhancing the sur-vival of COVID-19 patients.

Conclusion:
A double-blinded multicenter randomized controlled trial found survival benefits for imatinib with no significant treatment-related adverse events. However, no clinical trials or large observational studies exist for artesunate and nilotinib, and the evidence relies only on case reports and case series. Molecular mechanisms revealed in preclinical studies support the possible benefits of these medications in COVID-19 treatment. However, the scarcity of reliable evidence requires further studies on possible COVID-19 treatments, including but not limited to artesunate, nilotinib, and imatinib. Nevertheless, these drugs' lack of serious adverse events suggests their safe use for other indications during the COVID-19 pandemic.
A Free Man in Search of the Truth about Himself. An Attempt at a Moral-Theological Rein-terpretation of Sophocles’ “Oedipus The King”
Authors: Kuciński Andrzej Dominik 
Published: July 2023

Sophocles’ “Oedipus the King” is one of the oldest and most famous tragedies that belong to the common patrimony of humanity. It raises issues to which each generation must find its own answer. Some of these issues become particularly relevant at moments when the foundations of common anthropological concepts are shaken, as they are at the present time. The reference to pre-Christian literary works can be a starting point for a dialogue with those who do not share the Christian worldview but are open to an exchange of reflections about man. In this article the author, starting from the specifics of the adaptation of the myth in the Sophocles’ edition, through an outline of the wealth of interpretations of his tragedy through the centuries, arrives at a proposal for the moral-theological reinterpretation of this work in today’s world with the help of two examples: the question of the origin of the person in the context of parenthood and moral responsibility in a world dominated by individualism and a weakened belief in actual human freedom.