bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subtype-Specific Roles of Ellipsoid Body Ring Neurons in Sleep Regulation inDrosophila
Authors: Yan Wei , Lin Hai , Yu Junwei , Wiggin Timothy D. , Wu Litao , Meng Zhiqiang , Liu Chang , Griffith Leslie C. 
Published: December 2022

The ellipsoid body (EB) is a major structure of the central complex of theDrosophila melanogasterbrain. Twenty-two subtypes of EB ring neurons have been identified based on anatomic and morphologic characteristics by light-level microscopy and EM connectomics. A few studies have associated ring neurons with the regulation of sleep homeostasis and structure. However, cell type-specific and population interactions in the regulation of sleep remain unclear. Using an unbiased thermogenetic screen of EB drivers using female flies, we found the following: (1) multiple ring neurons are involved in the modulation of amount of sleep and structure in a synergistic manner; (2) analysis of data for ΔP(doze)/ΔP(wake) using a mixed Gaussian model detected 5 clusters of GAL4 drivers which had similar effects on sleep pressure and/or depth: lines driving arousal contained R4m neurons, whereas lines that increased sleep pressure had R3m cells; (3) a GLM analysis correlating ring cell subtype and activity-dependent changes in sleep parameters across all lines identified several cell types significantly associated with specific sleep effects: R3p was daytime sleep-promoting, and R4m was nighttime wake-promoting; and (4) R3d cells present in 5HT7-GAL4 and in GAL4 lines, which exclusively affect sleep structure, were found to contribute to fragmentation of sleep during both day and night. Thus, multiple subtypes of ring neurons distinctively control sleep amount and/or structure. The unique highly interconnected structure of the EB suggests a local-network model worth future investigation; understanding EB subtype interactions may provide insight how sleep circuits in general are structured.SIGNIFICANCE STATEMENTHow multiple brain regions, with many cell types, can coherently regulate sleep remains unclear, but identification of cell type-specific roles can generate opportunities for understanding the principles of integration and cooperation. The ellipsoid body (EB) of the fly brain exhibits a high level of connectivity and functional heterogeneity yet is able to tune multiple behaviors in real-time, including sleep. Leveraging the powerful genetic tools available inDrosophilaand recent progress in the characterization of the morphology and connectivity of EB ring neurons, we identify several EB subtypes specifically associated with distinct aspects of sleep. Our findings will aid in revealing the rules of coding and integration in the brain.
Condensin pinches a short negatively supercoiled DNA loop during each round of ATP usage
Authors: Martínez‐García Belén , Dyson Sílvia , Segura Joana , Ayats Alba , Cutts Erin E , Gutierrez‐Escribano Pilar , Aragón Luís , Roca Joaquim 
Published: December 2022

AbstractCondensin, an SMC (structural maintenance of chromosomes) protein complex, extrudes DNA loops using an ATP‐dependent mechanism that remains to be elucidated. Here, we show how condensin activity alters the topology of the interacting DNA. High condensin concentrations restrain positive DNA supercoils. However, in experimental conditions of DNA loop extrusion, condensin restrains negative supercoils. Namely, following ATP‐mediated loading onto DNA, each condensin complex constrains a DNA linking number difference (∆Lk) of −0.4. This ∆Lk increases to −0.8 during ATP binding and resets to −0.4 upon ATP hydrolysis. These changes in DNA topology do not involve DNA unwinding, do not spread outside the condensin‐DNA complex and can occur in the absence of the condensin subunit Ycg1. These findings indicate that during ATP binding, a short DNA domain delimited by condensin is pinched into a negatively supercoiled loop. We propose that this loop is the feeding segment of DNA that is subsequently merged to enlarge an extruding loop. Such a “pinch and merge” mechanism implies that two DNA‐binding sites produce the feeding loop, while a third site, plausibly involving Ycg1, might anchor the extruding loop.
Bio-Oil Production Using Waste Biomass via Pyrolysis Process: Mini Review
Authors: Nuraini Nuraini , Osman Noridah Binti , Astuti Erna 
Published: December 2022

Pyrolysis process using abundantly available biomass waste fabric is a promising, renewable, and sustainable energy supply for bio-oil production. In this study, the pyrolysis of waste biomass determines the highest yield of diverse parameters of material type, temperature, reactor, method, and analysis used. From the differences in the parameters stated above, there is an opportunity to select the proper parameters to get the desired nice and quantity of bio-oil and the very best bio-oil yield. The maximum yield of each bio-oil product for pyrolysis primarily based on the above parameters was 68.9%; 56.9%; 44.4%; 44.16%; 41.05%; 39.99%. The bio-oil made out of pyrolysis was changed into analyzed using GC-MS, ft-IR, NMR, TGA, SEM, Thermogravimetric analysis, HHV, FESEM evaluation methods and the substances used had been plastic, seaweeds, oat straw, rice straw , water hyacinth, timber sawdust, sawdust, microalgae.
Congenital Hypothyroidism: Screening and Management
Authors: Rose Susan R. , Wassner Ari J. , Wintergerst Kupper A. , Yayah-Jones Nana-Hawa , Hopkin Robert J. , Chuang Janet , Smith Jessica R. , Abell Katherine , LaFranchi Stephen H. ,   SECTION ON ENDOCRINOLOGY EXECUTIVE COMMITTEE, Wintergerst Kupper A. , Bethin Kathleen E. , Brodsky Jill L. , Jelley David H. , Marshall Bess A. , Mastrandrea Lucy D. , Lynch Jane L. , Laskosz Laura ,   COUNCIL ON GENETICS EXECUTIVE COMMITTEE, Burke Leah W. , Geleske Timothy A. , Holm Ingrid A. , Introne Wendy J. , Jones Kelly , Lyons Michael J. , Monteil Danielle C. , Pritchard Amanda B. , Smith Trapane Pamela Lyn , Vergano Samantha A. , Weaver Kathryn , Alexander Aimee A. , Cunniff Christopher , Null Mary E. , Parisi Melissa A. , Ralson Steven J , Scott Joan , Spire Paul 
Published: December 2022

Abstract
Untreated congenital hypothyroidism (CH) leads to intellectual disabilities. Prompt diagnosis by newborn screening (NBS) leading to early and adequate treatment results in grossly normal neurocognitive outcomes in adulthood. However, NBS for hypothyroidism is not yet established in all countries globally. Seventy percent of neonates worldwide do not undergo NBS.
The initial treatment of CH is levothyroxine, 10 to 15 mcg/kg daily. The goals of treatment are to maintain consistent euthyroidism with normal thyroid-stimulating hormone and free thyroxine in the upper half of the age-specific reference range during the first 3 years of life. Controversy remains regarding detection of thyroid dysfunction and optimal management of special populations, including preterm or low-birth weight infants and infants with transient or mild CH, trisomy 21, or central hypothyroidism.
Newborn screening alone is not sufficient to prevent adverse outcomes from CH in a pediatric population. In addition to NBS, the management of CH requires timely confirmation of the diagnosis, accurate interpretation of thyroid function testing, effective treatment, and consistent follow-up. Physicians need to consider hypothyroidism in the face of clinical symptoms, even if NBS thyroid test results are normal. When clinical symptoms and signs of hypothyroidism are present (such as large posterior fontanelle, large tongue, umbilical hernia, prolonged jaundice, constipation, lethargy, and/or hypothermia), measurement of serum thyroid-stimulating hormone and free thyroxine is indicated, regardless of NBS results.
How can the restorative idea survive in schools? Experiences of a professional development programme
Authors: Hera Gabor 
Published: December 2022

AbstractThis paper aims to detect the motivations, structures, and conditions that both promote and hinder commitment and buy-in regarding the implementation of restorative practices in schools. In addition, the components that contribute to the long-term sustainability of the restorative idea in school settings are also identified. The article summarizes the ideas and experiences of the trainers at the International Institute for Restorative Practices who were interviewed within the framework of a research programme. These trainers were responsible for providing professional development for middle and high schools in many states of the United States. As the author concludes, without thorough assessment of implementation readiness, professional development may fail and the restorative idea does not take root in schools.
IMPROVING THE EDDY CURRENT IDENTIFIER OF METALS BASED ON THE CORRELATION APPROACH
Authors: Abramovych А. О. 
Published: December 2022

Context. The article considers the problem of improving the eddy current device for metal identification on the basis of the correlation approach. This approach is convenient for the accumulation of a database of known leading materials, as well as for the comparison of the signal from an unknown metal object with the available standards in the database. The proposed approach allows to determine the type of metal from which the sample is made, without damaging its surface.
Objective. The aim of the work is the identification of metals by type on the feedback signals from the eddy current converter, due to the identification of new informative features and the creation of a database of images of metals.
Method. The paper presents the results of an experimental study of the proposed approach to increase the reliability of identification of metal objects that are detected using an eddy current device. These studies are conducted on the basis of a radio system that operates on the eddy current principle and has low-frequency magnetic loop antennas. The eddy current method allows the identification of metals by type remotely and without damaging their surface, in contrast to X-ray fluorescence, optical emission or chemical methods. A correlation approach for processing the response signal spectrum from a hidden metal object is proposed. The correlation approach allows to increase the reliability of the identification of metals by type when processing the signal in the spectral region based on the Fourier transform. Studies have been conducted on the example of metals that have similar spectral characteristics (silver, gold, lead). The updated approach allowed to increase the percentage difference between the information parameters of signals – responses from 1.87% to 5.02% for silver and gold, from 2.24% to 4.34% for silver and lead and from 0.36% to 0.7% for gold and lead.
Results. The developed radio system is a laboratory model, which consists of an analog part and a digital one. The analog part is an antenna unit, a signal amplifier and a bandpass filter, a digital part – a microcontroller with an ADC for digitizing and transmitting data to a laptop, which software implements the proposed approaches to signal processing. The paper experimentally confirmed the possibility of using a radio engineering system to solve the problem of metal identification within a subset of nonmagnetic and magnetic materials.
Conclusions. The development of modern eddy current devices is aimed at increasing the reliability of the identification the hidden metal objects, which is relevant in geophysical exploration, archeology, and law enforcement agencies in the search for hidden non-ferrous metals. The development and improvement of such systems includes both the development the hardware and the discovery new information parameters in the feedback signals from metals. One such direction may be the correlation approach to signal processing in the spectral region.
REWRITING IDENTIFICATION TECHNOLOGY FOR TEXT CONTENT BASED ON MACHINE LEARNING METHODS
Authors: Kholodna N. , Vysotska V. 
Published: December 2022

Context. Paraphrased textual content or rewriting is one of the difficult problems of detecting academic plagiarism. Most plagiarism detection systems are designed to detect common words, sequences of linguistic units, and minor changes, but are unable to detect significant semantic and structural changes. Therefore, most cases of plagiarism using paraphrasing remain unnoticed.
Objective of the study is to develop a technology for detecting paraphrasing in text based on a classification model and machine learning methods through the use of Siamese neural network based on recurrent and Transformer type – RoBERTa to analyze the level of similarity of sentences of text content.
Method. For this study, the following semantic similarity metrics or indicators were chosen as features: Jacquard coefficient for shared N-grams, cosine distance between vector representations of sentences, Word Mover’s Distance, distances according to WordNet dictionaries, prediction of two ML models: Siamese neural network based on recurrent and Transformer type - RoBERTa.
Results. An intelligent system for detecting paraphrasing in text based on a classification model and machine learning methods has been developed. The developed system uses the principle of model stacking and feature engineering. Additional features indicate the semantic affiliation of the sentences or the normalized number of common N-grams. An additional fine-tuned RoBERTa neural network (with additional fully connected layers) is less sensitive to pairs of sentences that are not paraphrases of each other. This specificity of the model may contribute to incorrect accusations of plagiarism or incorrect association of user-generated content. Additional features increase both the overall classification accuracy and the model’s sensitivity to pairs of sentences that are not paraphrases of each other.
Conclusions. The created model shows excellent classification results on PAWS test data: precision – 93%, recall – 92%, F1score – 92%, accuracy – 92%. The results of the study showed that Transformer-type NNs can be successfully applied to detect paraphrasing in a pair of texts with fairly high accuracy without the need for additional feature generation.
Business incubators in Brazil: realities and challenges
Authors: Ribeiro Priscilla Cristina Cabral , Alves de Matos Freire Kyane , Chudoba Katherine M , Borges Renault Thiago 
Published: December 2022

Purpose - The purpose of this paper is to describe five business incubators in Brazil through the Triple Helix model, their realities and challenges.Theoretical framework – A discussion of Business incubators, Triple Helix and the use of Information and Communication Technologies in incubators are the main lenses used to support the research.Design/methodology/approach – For this purpose, five case studies of incubators in the Northern and Southern Regions of Brazil were used. The paper uses a qualitative approach and collects data through semi-structured interviews. To analyze the results, the theory was compared to the findings from the field research.Findings - The results showed that most incubators are in public universities, the majority focus on technology, and some are diverse (social and cultural). Some internal and external partners help them with financial support. One of the challenges (maybe the most important) is a set of constraints because some lecturers cannot understand how to use academic knowledge in consultancy.Research, Practical & Social implications – The differences found between incubator categories are in the results that lead to this business model being more complex than it is in reality. The presentation of different incubator realities and challenges focusing on the discussion of ‘selling’ knowledge, the use of public resources by private enterprises, are the practical and social implications.Originality/value - The main contribution is to show the reality of these incubators, the empirical results, adding a new perspective to the discussion.Keywords - Business incubators; Challenges; Triple Helix; Information and Communication Technology.
Expansion of concrete by secondary ettringite formation due to fine recycled aggregates contaminated with gypsum
Authors: Colman Charlotte , Bulteel David , Elkarim Bouarroudj Mohamed , Rémond Sébastien , Courard Luc 
Published: December 2022

Recycled aggregates, especially the fine (0–4 mm) fraction, are often contaminated with sulfates coming from gypsum residues on demolition sites. When these aggregates are used in concrete, the sulfates can induce internal sulfate attack which causes expansion of the concrete. European standard EN 206:2013 sets the water-soluble sulfate limit at 0.2% by weight of the aggregate, but other studies suggest this limit could be safely increased. In addition to the sulfate content, other parameters, such as the porosity and alkalinity of the mix, have been shown to influence the swelling results. In this study, different proposed sulfate limits were evaluated on concrete made with 100% fine recycled aggregates (FRA). It was also researched whether the mixing parameters could change the swelling amount regardless of the sulfate content. The results showed that the incorporation of FRA with sulfate contents up to 0.8 wt% is safe when combined with coarse natural aggregates. If coarse recycled aggregates are used in the mix, the sulfate content of FRA can be up to 0.3%. The swelling caused by these sulfate levels was not high enough to be influenced by the porosity or alkalinity of the mix.
¿Jóvenes y adultos buscando el sentido de la vida? El deficiente proceso de emancipación hacia la madurez.
Authors: Tahull Fort Joan 
Published: December 2022

Los jóvenes españoles se emancipan tardíamente respecto la mayoría de los países europeos. Esta situación se repite en diferentes circunstancias -en periodos de bonanza y crisis económica-. Principalmente se hace referencia a sus dificultades para terminar los estudios, trabajo, vivienda…; sin tener en cuenta suficientemente aspectos sociales y culturales. La emancipación tardía y la semi-independencia de los jóvenes puede tener consecuencias diversas: deficiente e incompleto encaje a la vida adulta, infantilismo, conductas de riesgo, determinar el sistema de valores, proyecto de vida difuso… Para la realización de la investigación se presentan datos cuantitativos oficiales y también diferentes entrevistas a personas conocedoras de la temática. En algunos casos se vislumbra un vacío existencial y un proyecto vital epidérmico e incompleto. What do you want to do ?New mailCopy What do you want to do ?New mailCopy
<i>Psittacanthus longerectus</i> (Loranthaceae), a new showy species from Colombia
Authors: Roldán-Palacios Francisco J. , Alzate-Guarín Fernando 
Published: December 2022

We describe Psittacanthus longerectus (Loranthaceae), a species so far only known from Antioquia (Colombia) and discuss the taxonomic affinities of the new species with P. acinarius and P. cyclophyllus. Psittacanthus longerectus is characterized by having cordate leaves, erect branches, and terminal inflorescences.
Compatibilidad del hongo entomopatógeno <i>Purpureocillium</i> sp. cepa UdeA0106 con biocontroladores y productos fitosanitarios utilizados en cultivos de crisantemo
Authors: Gallego-Velásquez Jenny , Cardona-Bustos Nadya L. , Restrepo-Betancur Fernando 
Published: December 2022

El hongo entomopatógeno Purpureocillium sp. cepa UdeA0106 ha mostrado potencial para el control de sinfílidos (Scutigerella sp.), una plaga que ataca los cultivos de crisantemo, tanto in vitro como bajo condiciones de invernadero. En la actualidad, la cepa Purpureocillium sp. UdeA0106 se aplica en combinación con otros hongos biocontroladores, fungicidas e insecticidas en los sistemas de manejo integrado (IPM) en cultivos de crisantemo en el oriente de Antioquia, Colombia. Sin embargo, los aspectos ecológicos relacionados con la compatibilidad del hongo UdeA0106 y estas estrategias de control son desconocidos. Uno de los objetivos del presente trabajo fue la evaluación del antagonismo in vitro de la cepa Purpureocillium sp. UdeA0106 con los biocontroladores Beauveria bassiana (Vuill., 1912), Metarhizium anisopliae (Sorokin, 1883), Paecilomyces lilacinus [(Thom) Luangsa-ard, Houbraken, Hywel-Jones & Samson, 2011] y Trichoderma viride (Pers., 1794). Adicionalmente, y bajo condiciones de laboratorio, se estudió el efecto de productos fitosanitarios aplicados de forma regular en los cultivos de flores sobre Purpureocillium sp. UdeA0106. Los resultados obtenidos mostraron que el hongo UdeA0106 presentó compatibilidad in vitro con la mayoría de los hongos biocontroladores excepto con T. viride, mientras que el fungicida Carbovax® (carboxina + tiram) inhibió completamente la germinación y el crecimiento vegetativo del hongo. Los avances en la comprensión de la compatibilidad del hongo con otros productos que se aplican comúnmente en los cultivos de flores, permitirán un uso más eficiente de Purpureocillium sp. cepa UdeA0106 para el control de sinfílidos en cultivos de crisantemo.
Diferencias salariales asociadas a atributos ambientales en trece ciudades colombianas: una estimación de salarios hedónicos
Authors: Pérez Carlos Andrés , Arias Fabio 
Published: December 2022

El principal objetivo de este artículo es determinar cuál es la valoración que las personas tienen por la sensación de bienestar físico asociado de manera directa al clima. Para ello, se identifican, a través de la estimación de un modelo de salarios hedónicos, las diferencias de salario entre las trece capitales más importantes de Colombia en el año 2003; se incluye el indicador de confort térmico entre las variables del modelo. El artículo prueba la existencia de diferenciales de salario asociadas a características ambientales y de convivencia y seguridad entre ciudades. También se verifica que las variables ambientales pueden incidir en los ajustes del mercado de trabajo. Palabras clave: salarios hedónicos, Colombia, confort térmico, calidad de vida, mercado laboral. Clasificación JEL: Q51, Q54, R13. Abstract: This paper estimates people’s valuation for the sensation of physical wellbeing directly associated with the weather. In order to accomplish this, it identifies, using an estimation of a hedonic wage model, the wage differentials between thirteen of the largest and most important Colombian cities for 2003. It includes, among the variables, a human thermal comfort index related to average climatic conditions. The paper finds the existence of wage differentials associated with both weather conditions, and community and security characteristics. It also finds that climatic variables may impinge on labor market adjustments. Keywords: hedonic wages, Colombia, thermal comfort, quality of life, labor market. JEL classification: Q51, Q54, R13. Résumé: Cet article fournie une estimation concernant le bien-être physique de la population associé au climat. Pour ce faire, on identifie les différentiels salariaux dans les treize villes les plus importantes de Colombie pendant l’année 2003, en utilisant un modèle des salaires hédoniques. On considère un indicateur de confort thermique parmi les variables du modèle. Nous montrons l’existence des différentiels salariaux entre les villes lesquels sont associés à l’environnement, à la coexistence citoyenne et à la sécurité. Egalement, nous constatons que les variables environnementales ont une incidence dans les ajustements du marché du travail. Mots clés: salaires hédoniques, Colombie, confort thermique, qualité de vie, marché du travail. Classification JEL: Q51, Q54, R13.