bluuebunny/crossref_metadata_2025_split huggingface dataset:
First detected geographical cluster of BoDV-1 encephalitis from same small village in two children: therapeutic considerations and epidemiological implications
Authors: Grosse Leonie , Lieftüchter Victoria , Vollmuth Yannik , Hoffmann Florian , Olivieri Martin , Reiter Karl , Tacke Moritz , Heinen Florian , Borggraefe Ingo , Osterman Andreas , Forstner Maria , Hübner Johannes , von Both Ulrich , Birzele Lena , Rohlfs Meino , Schomburg Adrian , Böhmer Merle M. , Ruf Viktoria , Cadar Dániel , Muntau Birgit , Pörtner Kirsten , Tappe Dennis 
Published: February 2023

AbstractBackgroundThe Borna disease virus (BoDV-1) is an emerging zoonotic virus causing severe and mostly fatal encephalitis in humans.Methods and ResultsA local cluster of fatal BoDV-1 encephalitis cases was detected in the same village three years apart affecting two children. While the first case was diagnosed late in the course of disease, a very early diagnosis and treatment attempt facilitated by heightened awareness was achieved in the second case. Therapy started as early as day 12 of disease. Antiviral therapy encompassed favipiravir and ribavirin, and, after bioinformatic modelling, also remdesivir. As the disease is immunopathogenetically mediated, an intensified anti-inflammatory therapy was administered. Following initial impressive clinical improvement, the course was also fatal, although clearly prolonged. Viral RNA was detected by qPCR in tear fluid and saliva, constituting a possible transmission risk for health care professionals. Highest viral loads were foundpost mortemin the olfactory nerve and the limbic system, possibly reflecting the portal of entry for BoDV-1. Whole exome sequencing in both patients yielded no hint for underlying immunodeficiency. Full virus genomes belonging to the same cluster were obtained in both cases by next-generation sequencing. Sequences were not identical, indicating viral diversity in natural reservoirs. Specific transmission events or a common source of infection were not found by structured interviews. Patients lived 750m apart from each other and on the fringe of the settlement, a recently shown relevant risk factor.ConclusionOur report highlights the urgent necessity of effective treatment strategies, heightened awareness and early diagnosis. Gaps of knowledge regarding risk factors, transmission events, and tailored prevention methods become apparent. Whether this case cluster reflects endemicity or a geographical hot spot needs further investigation.
Change in gliding properties of the iliotibial tract in hypermobile Ehlers–Danlos Syndrome
Authors: Wang Tina J. , Stecco Antonio , Schleip Robert , Stecco Carla , Pirri Carmelo 
Published: February 2023

Abstract
Purpose
Fascial changes in hypermobile Ehlers–Danlos syndrome (hEDS), a heritable connective tissue disorder, can be used visualized with sonoelastography. The purpose of this study was to explore the inter-fascial gliding characteristics in hEDS.

Methods
In 9 subjects, the right iliotibial tract was examined with ultrasonography. Tissue displacements of the iliotibial tract were estimated from ultrasound data using cross-correlation techniques.

Results
In hEDS subjects, shear strain was 46.2%, lower than those with lower limb pain without hEDS (89.5%) and in control subjects without hEDS and without pain (121.1%).

Conclusion
Extracellular matrix changes in hEDS may manifest as reduced inter-fascial plane gliding.
Was tun? Perspektiven für eine Unterrichtsqualitätsforschung der Zukunft
Authors: Begrich Lukas , Praetorius Anna-Katharina , Decristan Jasmin , Fauth Benjamin , Göllner Richard , Herrmann Christian , Kleinknecht Marc , Taut Sandy , Kunter Mareike 
Published: February 2023

ZusammenfassungDie Unterrichtsqualitätsforschung hat in den vergangenen Jahrzehnten viel zum Verständnis der Merkmale beitragen, die einen qualitätsvollen Unterricht auszeichnen. Sie hat einflussreiche Modelle hervorgebracht, die eine gemeinsame Grundlage für die Erforschung des Unterrichts bereitstellen. Gleichzeitig bringen gesellschaftliche Veränderungsprozesse eine Neuorientierung des schulischen Unterrichts mit sich, und es lässt sich fragen, ob die Unterrichtsqualitätsforschung mit ihren bisherigen Ansätzen in der Lage ist, in Zukunft zum Gelingen von Unterricht beizutragen. Im Rahmen einer Zukunftswerkstatt hat das Leibniz-Netzwerk Unterrichtsforschung daher einen längerfristig angelegten Prozess gestartet, um sich mit dem Unterricht der Zukunft zu beschäftigen und zu versuchen, drängende Fragen und Handlungsfelder für die Unterrichtsqualitätsforschung zu identifizieren. Der vorliegende Beitrag stellt die Ergebnisse dieses initialen Austauschs dar. Zudem wird ein Einblick in die gegenwärtige Arbeit im Netzwerk gegeben, die aufbauend auf den Ergebnissen der Zukunftswerkstatt eine Weiterentwicklung der Unterrichtsqualitätsforschung anstrebt.
Eco-Friendly Collectors for Flotation of Fine Hematite and Malachite Particles
Authors: Slabov Vladislav , Jain Garima , Larsen Erik , Kota Hanumantha Rao , Chernyshova Irina 
Published: February 2023

Abstract
The separation of fine mineral particles, especially using environmentally friendly approaches, is one of the main problems in the processing of low-grade ores and the re-processing of mining tailings. This work assesses the potential of biosurfactants as collectors in the flotation of ultrafine (smaller than 20 μm) particles of hematite and malachite. As biosurfactants, we test acetylated acidic (ac-ASL) and lactonic sophorolipids (ac-LSL). In addition, n-dodecyl-β-D-maltoside (DDM) is used as a model non-ionic alkyl disaccharide surfactant, and sodium oleate (NaOl) is used as a reference. The biosurfactants are characterized using surface tension and foam analysis. The interaction of the minerals with the surfactants is characterized using zeta potential, solubility, and single-mineral flotation. The collecting properties of the surfactants are compared for the ultrafine (− 20 μm) and coarser (38–90 µm) particle size in the two-mineral flotation of hematite and malachite against quartz. The ultrafine particle size improves the grade in the oleate flotation of hematite, as well as the grades in the DDM flotation of hematite and malachite, which is explained by the weak interactions of the metal oxides with fatty acids and DDM. At the same time, the flotation with ac-LSL and ac-ASL is highly tolerant to the ultrafine particle size. These results indicate that biosurfactants are an interesting alternative to conventional petroleum-based surfactants in the flotation of Fe and Cu oxides. Moreover, a proper selection of surfactants can help combat the problem of fines.
Graphical Abstract
Interactive Input and Visualization for Planning with Temporal Uncertainty
Authors: Höhn Markus , Wunderlich Marcel , Ballweg Kathrin , Kohlhammer Jörn , Landesberger Tatiana von 
Published: February 2023

AbstractWhen planning series of events or processes, everyone has to cope with temporal uncertainty. Popular examples are holiday planning or train trips. There are several approaches to visualize temporal uncertainty when temporal data and events are already defined, but common research usually does not take uncertainty into account, neither as input nor output. To develop our design, we considered a variety of common approaches for uncertainty visualization and used participatory evaluation to validate our concept. Our design aims at using this uncertainty visualization while sketching the plan interactively. The user may draw and connect a variety of activities using different graphical metaphors as hints for uncertainty. The sketches are immediately interpreted and turned into a visualization to check and validate the resulting plan. To evaluate our new visualization and interactive approach, we conducted a quantitative user study. With an average correctness of 81%, the study shows that the visualization and interaction design work well together and that scheduling plans containing temporal uncertainties can be externalized by the majority of participants without major difficulties.
The Circular Economy and Circular Building Practices in Luxembourg
Authors: Hild Paula 
Published: February 2023

AbstractThis article analyses the circular economy in Luxembourg using a retroductive approach to the study of practices. It presents the circular economy vision in Luxembourg as a governmental concept since 2015 that operationalises mainly within the building sector. Based on 66 semi-structured interviews with key stakeholders, the article expands on what circularity means for architects, engineers, and building firms. In this sense, the building sector in Luxembourg deals with three main topics: (a) circular design concepts, (b) circular materials management (i.e. materials passport), and (c) digitisation. The article discusses construction as a bundle of activities that constitutes shared meanings, materials, and competence. The findings illustrate that the circular economy foci in the literature and Luxembourg are path-dependent and mirror the European and national history of sustainability concepts in construction. If and how the circular economy and circular practices contribute to sustainable development in the country still needs consideration and monitoring.
Temporal variation of wall flow and its influences on energy balance of the building wall
Authors: Chen Yichen , Wang Shaopeng , Yang Xinyan , Fan Yifan , Ge Jian , Li Yuguo 
Published: February 2023

AbstractThe characteristics of energy balance and heat transfer on building walls are important for building energy consumption and outdoor thermal/wind environment. The in-situ measurement of energy balance and wall flows during clear days on a 16-story building in Guangzhou, China is introduced and analyzed in this paper. The velocity along the wall was measured by 3D ultrasonic anemometers. The surface temperature was measured by infrared camera and thermal couples. The ambient temperature, relative humidity, wind velocity and solar radiation were recorded by weather stations. The Rayleigh number of wall flows reached as high as 1.44 × 1014. We found that the different kinds of heat flux reach their maximum value in a day cycle at different times. The transmittance of the atmosphere keeps decreasing from sunrise to sunset on Guangzhou’s typical clear days thus inducing different incoming solar radiation. The wall surface temperature and air flow were visualized by infrared videos. The diurnal change of energy balance on the south facing wall was calculated based on the solar radiation, long wave radiation and heat transfer caused by natural convection adjacent to the wall.
Aerodynamic characterisation of delta wing unmanned aerial vehicle using non-gradient-based estimator
Authors: Kumar N. , Saderla S. , Kim Y. 
Published: February 2023

AbstractAerodynamic characterisation from flight testing is an integral subroutine for evaluating a new flight vehicle’s aerodynamic performance, stability and controllability. The estimation of aerodynamic parameters from flight test data has extensively been explored, in the past, using estimation methods such as the equation error method, output error method and filter error method. However, in the current era, non-gradient-based estimation techniques are gaining attention from researchers due to their inherent data-driven optimisation capability to find the global best solution. In this paper, a novel non-gradient-based estimation method is proposed for the aerodynamic characterisation of unmanned aerial vehicles from flight data, which relies on the maximum likelihood method augmented with particle swarm optimisation. Flight data sets of a wing-alone unmanned aerial vehicle are used to demonstrate the capabilities of the proposed method in estimating aerodynamic derivatives. Estimates from the proposed method are corroborated with the wind tunnel test and output error method results. It has been observed that simulated flight vehicle responses using estimated parameters are in good agreement with measured data in most of the manoeuvers considered. Confidence in the estimates of linear and nonlinear aerodynamic parameters is well established with the lower limit of Cramer-Rao bounds, which are minimal. The proposed method also demonstrates good predictability of the quasi-steady stall aerodynamic model by estimating stall characteristic parameters such as aerofoil static stall characteristics parameter, hysteresis time constant and breakpoint. The overall performance of the proposed estimation method is on par with the output error method and is validated with the proof-of-match exercise.
Skillful statistical prediction of subseasonal temperature by training on dynamical model data
Authors: Trenary Laurie , DelSole Timothy 
Published: February 2023

Abstract
This paper derives statistical models for predicting wintertime subseasonal temperature over the western US. The statistical models are trained on two separate datasets, namely observations and dynamical model simulations, and are based on least absolute shrinkage and selection operator (lasso). Surprisingly, statistical models trained on dynamical model simulations can predict observations better than observation-trained models. One reason for this is that simulations involve orders of magnitude more data than observational datasets.
Grassmanniennes affines tordues sur les entiers
Authors: Lourenço João 
Published: February 2023

Abstract
We generalize the works of Pappas–Rapoport–Zhu on twisted affine Grassmannians to the wildly ramified case under mild assumptions. This rests on a construction of certain smooth affine

$\mathbb {Z}[t]$

-groups with connected fibers of parahoric type, motivated by previous work of Tits. The resulting

$\mathbb {F}_p(t)$

-groups are pseudo-reductive and sometimes non-standard in the sense of Conrad–Gabber–Prasad, and their

$\mathbb {F}_p [\hspace {-0,5mm}[ {t} ]\hspace {-0,5mm}] $

-models are parahoric in a generalized sense. We study their affine Grassmannians, proving normality of Schubert varieties and Zhu’s coherence theorem.
A quality-improvement approach to urgent-care antibiotic stewardship for respiratory tract infections during the COVID-19 pandemic: Lessons learned
Authors: Ong’uti Sharon K. , Artandi Maja , Betts Brooke , Weng Yingjie , Desai Manisha , Lentz Christopher , Nelligan Ian , Ha David R. , Holubar Marisa K. 
Published: February 2023

AbstractObjective:We investigated a decrease in antibiotic prescribing for respiratory illnesses in 2 academic urgent-care clinics during the coronavirus disease 2019 (COVID-19) pandemic using semistructured clinician interviews.Methods:We conducted a quality-improvement project from November 2020 to May 2021. We investigated provider antibiotic decision making using a mixed-methods explanatory design including interviews. We analyzed transcripts using a thematic framework approach to identify emergent themes. Our performance measure was antibiotic prescribing rate (APR) for encounters with respiratory diagnosis billing codes. We extracted billing and prescribing data from the electronic medical record and assessed differences using run charts, p charts and generalized linear regression.Results:We observed significant reductions in the APR early during the COVID-19 pandemic (relative risk [RR], 0.20; 95% confidence interval [CI], 0.17–0.25), which was maintained over the study period (P < .001). The average APRs were 14% before the COVID-19 pandemic, 4% during the QI project, and 7% after the project. All providers prescribed less antibiotics for respiratory encounters during COVID-19, but only 25% felt their practice had changed. Themes from provider interviews included changing patient expectations and provider approach to respiratory encounters during COVID-19, the impact of increased telemedicine encounters, and the changing epidemiology of non–COVID-19 respiratory infections.Conclusions:Our findings suggest that the decrease in APR was likely multifactorial. The average APR decreased significantly during the pandemic. Although the APR was slightly higher after the QI project, it did not reach prepandemic levels. Future studies should explore how these factors, including changing patient expectations, can be leveraged to improve urgent-care antibiotic stewardship.
On the cumulant transforms for Hawkes processes
Authors: Lee Young , Rheinländer Thorsten 
Published: February 2023

AbstractWe consider the asset price as the weak solution to a stochastic differential equation driven by both a Brownian motion and the counting process martingale whose predictable compensator follows shot-noise and Hawkes processes. In this framework, we discuss the Esscher martingale measure where the conditions for its existence are detailed. This generalizes certain relationships not yet encountered in the literature.
Representations of numerals in Tibetan–Mandarin bilinguals
Authors: Han Haibin , An Ning , Zhou Xinlin , Cui Zhanling 
Published: February 2023

AbstractAdopting a cross-language long-term repetition-priming paradigm, the current study systematically investigated number representation in Tibetan–Mandarin bilinguals. The study focused on three types of numerals: Arabic digits, Tibetan numerals, and Mandarin numerals. Experiment 1 examined lexical representation; participants performed a lexical decision task in the cross-language repetition-priming paradigm. Experiment 2 used a parity judgment task to examine conceptual representation. In both experiments, if the presentation of the numerals during the learning phase facilitated responses to their translation equivalents in the testing phase, it would indicate that they activate each other (i.e., a shared representation). Results showed that the presentation of Tibetan or Mandarin numerals did not facilitate subsequent responses to the Arabic digit equivalent. No cross-language repetition-priming effect between Tibetan and Mandarin numerals was found in the lexical decision task, indicating that Arabic digits, Tibetan number words, and Mandarin number words are stored separately at the lexical level. At the conceptual level, the results were quite the opposite, suggesting that these three types of numerals share a common representation. To sum up, the results imply that bilinguals’ number representation is similar to bilinguals’ language representation, providing a better understanding of number representation in bilinguals from a linguistic perspective.
LINES ON HOLOMORPHIC CONTACT MANIFOLDS AND A GENERALIZATION OF -DISTRIBUTIONS TO HIGHER DIMENSIONS
Authors: HWANG JUN-MUK , LI QIFENG 
Published: February 2023

AbstractSince the celebrated work by Cartan, distributions with small growth vector
$(2,3,5)$
have been studied extensively. In the holomorphic setting, there is a natural correspondence between holomorphic
$(2,3,5)$
-distributions and nondegenerate lines on holomorphic contact manifolds of dimension 5. We generalize this correspondence to higher dimensions by studying nondegenerate lines on holomorphic contact manifolds and the corresponding class of distributions of small growth vector
$(2m, 3m, 3m+2)$
for any positive integer m.
Frond orientations with independent current indicators demonstrate the reclining rheotropic mode of life of several Ediacaran rangeomorph taxa
Authors: Pérez-Pinedo Daniel , Neville Jenna M. , Pasinetti Giovanni , McKean Christopher , Taylor Rod , McIlroy Duncan 
Published: February 2023

AbstractFossils from the deep-sea Ediacaran biotas of Newfoundland are among the oldest architecturally complex soft-bodied macroorganisms on Earth. Most organisms in the Mistaken Point–type biotas of Avalonia—particularly the fractal-branching frondose Rangeomorpha— have been traditionally interpreted as living erect within the water column during life. However, due to the scarcity of documented physical sedimentological proxies associated with fossiliferous beds, Ediacaran paleocurrents have been inferred in some instances from the preferential orientation of fronds. This calls into question the relationship between frond orientation and paleocurrents. In this study, we present an integrated approach from a newly described fossiliferous surface (the “Melrose Surface” in the Fermeuse Formation at Melrose, on the southern portion of the Catalina Dome in the Discovery UNESCO Global Geopark) combining: (1) physical sedimentological evidence for paleocurrent direction in the form of climbing ripple cross-lamination and (2) a series of statistical analyses based on modified polythetic and monothetic clustering techniques reflecting the circular nature of the recorded orientation ofFractofusus misraispecimens. This study demonstrates the reclining rheotropic mode of life of the Ediacaran rangeomorph taxonFractofusus misraiand presents preliminary inferences suggesting a similar mode of life forBradgatiasp. andPectinifrons abyssalisbased on qualitative evidence. These results advocate for the consideration of an alternative conceptual hypothesis for position of life of Ediacaran organisms in which they are interpreted as having lived reclined on the seafloor, in the position that they are preserved.
Against Evidential Pluralism in Pharmaceutical Regulation
Authors: Sung Doohyun , Holman Bennett 
Published: February 2023

AbstractWe examine arguments regarding the use of mechanistic evidence in assessing treatment efficacy and find that advocates and critics of EBM+ have largely been talking past each other due to a difference in focus. We explore aducanumab for the treatment of Alzheimer’s disease as a case that may speak to the role of EBM+ in pharmaceutical regulation. The case suggests the debate may be more fruitful if philosophers confine debates to particular domains of medicine and weigh in prospectively instead of relying on historical cases in which outcomes are known and that are susceptible to hindsight bias.
On the Logical Structure of Best Explanations
Authors: Schupbach Jonah N. 
Published: February 2023

AbstractStandard articulations of Inference to the Best Explanation (IBE) imply the uniqueness claim that exactly one explanation should be inferred in response to an explanandum. This claim has been challenged as being both too strong (sometimes agnosticism between candidate explanatory hypotheses seems the rational conclusion) and too weak (in cases where multiple hypotheses might sensibly be conjointly inferred). I propose a novel interpretation of IBE that retains the uniqueness claim while also allowing for agnostic and conjunctive conclusions. I then argue that a particular probabilistic explication of explanatory goodness helpfully guides us in navigating such options when using IBE.