bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas
Authors: Tabor Joanna K. , O’Brien Joseph , Vasandani Sagar , Vetsa Shaurey , Lei Haoyi , Jalal Muhammad I. , Marianayagam Neelan J. , Jin Lan , Millares Chavez Miguel , Haynes Joseph , Dincer Alper , Yalcin Kanat , Aguilera Stephanie M. , Omay Sacit Bulent , Mishra-Gorur Ketu , McGuone Declan , Morales-Valero Saul F. , Fulbright Robert K. , Gunel Murat , Erson-Omay E. Zeynep , Moliterno Jennifer 
Published: May 2023

OBJECTIVE
Mutations in NF2 are the most common somatic driver mutation in sporadic meningiomas. NF2 mutant meningiomas preferentially arise along the cerebral convexities—however, they can also be found in the posterior fossa. The authors investigated whether NF2 mutant meningiomas differ in clinical and genomic features based on their location relative to the tentorium.

METHODS
Clinical and whole exome sequencing (WES) data for patients who underwent resection of sporadic NF2 mutant meningiomas were reviewed and analyzed.

RESULTS
A total of 191 NF2 mutant meningiomas were included (165 supratentorial, 26 infratentorial). Supratentorial NF2 mutant meningiomas were significantly associated with edema (64.0% vs 28.0%, p < 0.001); higher grade—i.e., WHO grade II or III (41.8% vs 3.9%, p < 0.001); elevated Ki-67 (55.0% vs 13.6%, p < 0.001); and larger volume (mean 45.5 cm3 vs 14.9 cm3, p < 0.001). Furthermore, supratentorial tumors were more likely to harbor the higher-risk feature of chromosome 1p deletion (p = 0.038) and had a larger fraction of the genome altered with loss of heterozygosity (p < 0.001). Infratentorial meningiomas were more likely to undergo subtotal resection than supratentorial tumors (37.5% vs 15.8%, p = 0.021); however, there was no significant difference in overall (p = 0.2) or progression-free (p = 0.4) survival.

CONCLUSIONS
Supratentorial NF2 mutant meningiomas are associated with more aggressive clinical and genomic features as compared with their infratentorial counterparts. Although infratentorial tumors have higher rates of subtotal resection, there is no associated difference in survival or recurrence. These findings help to better inform surgical decision-making in the management of NF2 mutant meningiomas based on location, and may guide postoperative management of these tumors.
Impact of neighborhood deprivation and social vulnerability on long-term outcomes and desire for revision in patients with craniosynostosis
Authors: Varagur Kaamya , Murphy John , Ochoa Esther , Skolnick Gary B. , Naidoo Sybill D. , McEvoy Sean D. , Strahle Jennifer M. , Patel Kamlesh B. 
Published: May 2023

OBJECTIVE
The authors utilized the area deprivation index (ADI), a validated composite measure of socioeconomic disadvantage, and the social vulnerability index (SVI) to examine whether differences in neighborhood deprivation impact interventions and outcomes among patients with craniosynostosis.

METHODS
Patients who underwent craniosynostosis repair between 2012 and 2017 were included. The authors collected data about demographic characteristics, comorbidities, follow-up visits, interventions, complications, desire for revision, and speech, developmental, and behavioral outcomes. National percentiles for ADI and SVI were determined using zip and Federal Information Processing Standard (FIPS) codes. ADI and SVI were analyzed by tertile. Firth logistic regressions and Spearman correlations were used to assess associations between ADI/SVI tertile and outcomes/interventions that differed on univariate analysis. Subgroup analysis was performed to examine these associations in patients with nonsyndromic craniosynostosis. Differences in length of follow-up among the nonsyndromic patients in the different deprivation groups were assessed with multivariate Cox regressions.

RESULTS
In total, 195 patients were included, with 37% of patients in the most disadvantaged ADI tertile and 20% of patients in the most vulnerable SVI tertile. Patients in more disadvantaged ADI tertiles were less likely to have physician-reported desire (OR 0.17, 95% CI 0.04–0.61, p < 0.01) or parent-reported desire (OR 0.16, 95% CI 0.04–0.52, p < 0.01) for revision, independent of sex and insurance status. In the nonsyndromic subgroup, inclusion in a more disadvantaged ADI tertile was associated with increased odds of speech/language concerns (OR 4.42, 95% CI 1.41–22.62, p < 0.01). There were no differences in interventions received or outcomes among SVI tertiles (p ≥ 0.24). Neither ADI nor SVI tertile was associated with risk of loss to follow-up among nonsyndromic patients (p ≥ 0.38).

CONCLUSIONS
Patients from the most disadvantaged neighborhoods may be at risk for poor speech outcomes and different standards of assessment for revision. Neighborhood measures of disadvantage represent a valuable tool to improve patient-centered care by allowing for modification of treatment protocols to meet the unique needs of patients and their families.
Defining the minimal clinically important difference in smartphone-based mobility after spine surgery: correlation of survey questionnaire to mobility data
Authors: Chauhan Daksh , Ahmad Hasan S. , Subtirelu Robert , Mannam Sai , Turlip Ryan , Bryan Kevin , Bathula Shreya , Ghenbot Yohannes , Yang Andrew I. , Wang Michael Y. , Basil Gregory , Ali Zarina S. , Yoon Jang W. 
Published: May 2023

OBJECTIVE
Patient-reported outcome measures (PROMs) are the gold standard for assessing postoperative outcomes in spine surgery. However, PROMs are also limited by the inherent subjectivity of self-reported qualitative data. Recent literature has highlighted the utility of patient mobility data streamed from smartphone accelerometers as an objective measure of functional outcomes and complement to traditional PROMs. Still, for activity-based data to supplement existing PROMs, they must be validated against current metrics. In this study, the authors assessed the relationships and concordance between longitudinal smartphone-based mobility data and PROMs.

METHODS
Patients receiving laminectomy (n = 21) or fusion (n = 10) between 2017 and 2022 were retrospectively included. Activity data (steps-per-day count) recorded in the Apple Health mobile application over a 2-year perioperative window were extracted and subsequently normalized to allow for intersubject comparison. PROMS, including the visual analog scale (VAS), Patient Reported Outcome Measurement Information System Pain Interference (PROMIS-PI), Oswestry Disability Index (ODI), and EQ-5D, collected at the preoperative and 6-week postoperative visits were retrospectively extracted from the electronic medical record. Correlations between PROMs and patient mobility were assessed and compared between patients who did and those who did not achieve the established minimal clinically important difference (MCID) for each measure.

RESULTS
A total of 31 patients receiving laminectomy (n = 21) or fusion (n = 10) were included. Change between preoperative and 6-week postoperative VAS and PROMIS-PI scores demonstrated moderate (r = −0.46) and strong (r = −0.74) inverse correlations, respectively, with changes in normalized steps-per-day count. In cohorts of patients who achieved PROMIS-PI MCID postoperatively, indicating subjective improvement in pain, there was a 0.784 standard deviation increase in normalized steps per day, representing a 56.5% improvement (p = 0.027). Patients who did achieve the MCID of improvement in either PROMIS-PI or VAS after surgery were more likely to experience an earlier sustained improvement in physical activity commensurate to or greater than their preoperative baseline (p = 2.98 × 10−18) than non-MCID patients.

CONCLUSIONS
This study demonstrates a strong correlation between changes in mobility data extracted from patient smartphones and changes in PROMs following spine surgery. Further elucidating this relationship will allow for more robust supplementation of existing spine outcome measure tools with analyzed objective activity data.
Pengaruh Teknik Silase Pakan Komplit Tersuplementasi Ampas Tahu Berprotein Kasar Berlebih pada Domba Secara InVivo
Authors: Sujarnoko Tekad Urip Pambudi , Budiono Dwi , Firmansyah Dudi , Rahmawati Tenti 
Published: May 2023

Tofu dregs are feed ingredients with high nutritional content and easy to rot. Therefore a silage storage technique is needed to preserve and reduce environmental pollution. The process of preserving high-protein feed by silage has a weakness in the process of lowering the pH. This happens because the ammonia from the deamination process is alkaline . The silage processing can converting some nutrients into organic acids which can improve livestock health and production. The Complete feed silage which was supplemented with tofu dregs was carried out on thin-tailed local rams aged 8-10 months and body weight 16-18 kg. The rams were grouped to 4 groups. The first gorup was P0 = complete feed which was suplemented with tofu dregs without silage processing compared to P1 = P0 + silage processing which was fermented for at least 14 days. The data then analyzed using t-independent method in a randomized block design on the basis of body weight. The results of the study showed that the average dry matter consumption of livestock was not significantly different P>0.1, the increase in monthly weight was higher in group P1 with a P value <0.05, the silage process increased the efficiency of p<0.05. Both treatment had no effect on cholesterol, blood urea nitrogen (BUN), glucose, red blood grains and white blood grains. So it can be concluded that feeding by silage is better than fresh

.
Keywords: Silage, rams, tofu dregs
НОВА УКРАЇНСЬКА ШКОЛА: ОСВІТНЄ СЕРЕДОВИЩЕ ДЛЯ ДІТЕЙ З ОСОБЛИВИМИ ОСВІТНІМИ ПОТРЕБАМИ
Authors: Дука Володимир 
Published: May 2023

У статті здійснено теоретичний аналіз поняття «Нова українська школа» у сучасній педагогічній літературі та обґрунтувано положення щодо реалії і перспективи розвитку освітнього середовища для дітей з особливими освітніми потребами в умовах Нової української школи. У статті розкриваються етапи становлення сучасної концепції повної загальної середньої освіти України. Наведено аналіз праць сучасної педагогічної науки з проблеми «Нова українська школа». Визначено особливості становлення поняття «Нова Українська школа». Обґрунтувано положення щодо реалії і перспективи розвитку освітнього середовища для дітей з особливими освітніми потребами в умовах Нової української школи.Окреслено компоненти, якими з боку держави та місцевої громади як повноправного учасника освіти має забезпечуватися успішна організація навчально-виховного процесу, охарактеризовано 10 ключових компетентностей Нової української школи. Визначено поняття освітньої компетентності. Автор акцентує увагу на тому, що розбудова Нової української школи – це довготермінова реформа, яка реалізується на даному етапі. ЇЇ упровадження передбачає наступність дій і відповідне ресурсне забезпечення на кожному етапі, а також враховує загальний контекст суспільних змін Визначено багатокомпонентну структуру освітньої реформи. Виділено основні структурні компоненти та окреслено систему освіти саме для дітей з особливими освітніми потребами в Новій Українській школі.Зазначено, що першочерговим є вирішення питання моделювання якісного та ефективного освітнього середовища для дітей з особливими освітніми потребами з урахуванням концептуальних положень Нової української школи, спрямованого на підготовку дітей до самостійного життя у суспільстві. Наголошено, що освітнє середовище має відображати філософію концепції Нової української школи та освітню програму, оскільки усі діти мають право навчатися у такому середовищі, де забезпечуються їхні потреби – базові потреби, потреби у навчанні, додаткові потреби (для дітей з особливими освітніми потребами). Дано узагальнене визначення поняття «Нова Українська школа» , яке є актуальним для даного дослідження.
Analisis Potensi Pengembangan Wisata Halal sebagai Lapangan Baru untuk Peningkatan Ekonomi Masyarakat Desa Kendan Kecamatan Nagreg Kabupaten Bandung
Authors: R Rukmana Asep , Kurniawan Purnomo Albert 
Published: May 2023

Penelitian ini mengambil judul Analisis Potensi Pengembangan Wisata Halal Sebagai Lapangan Baru Untuk Peningkatan Ekonomi Masyarakat Desa Kendan Kecamatan Nagreg Kabupaten Bandung. Penelitian ini bertujuan untuk mengetahui potensi pengembangan wisata halal di wilayah Desa Kendan Kecamatan Nagreg Kabupaten Bandung. Metode peneltian pada penelitian ini menggunakan pendekatan kualitatif. Penelitian ini berlangsung selama 6 bulan mulai dari Juli sampai Desember 2022. Teknik pengumpulan data yang akan dilakukan berupa wawancara, kuesioner dan dokumentasi.
Wisata halal di Indonesia khususnya Jawa Barat menjadi memiliki nilai potensial dan mampu mendorong perekonomian Indonesia menjadi unggul dan kuat. Hasil tersebut berujung pada pendapatan negara menjadi meningkat. merupakan potensi ekonomi yang unggul sebagai pemasok penerimaan negara. Banyak daerah dengan potensi tujuan wisata menawarkan program menarik guna meningkatkan jumlah wisatawan di Indonesia, pariwisata halal memiliki prospek pengembangan yang tinggi. Tujuan penelitian ini adalah untuk mengidentifikasi potensi wisata halal dan mengembangkan wisata halal di Indonesia.
Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan pendekatan kualitatif. Hasil Penelitian menunjukan bahwa banyak potensi yang mampu dieksplorasi dari Desa Kendan. Wisata alam, wisata religi, dan harapan semua jenis wisata tersebut didukung pemerintah daerah dan Bupati Bandung.
Intramolecularly Stabilized o-Carboranyl Aluminum Complexes: Synthesis, Characterization, and X-ray Structural Studies
Authors: Sohn Honglae , Lee Jong-Dae 
Published: May 2023

The chelating aluminum complex [2-(Me2NCH2)C2B10H10]AlX2 (X = Br 3, CH3 4) was synthesized using 2-dimethylaminomethyl-o-carboranyl lithium (LiCabN, 2) with aluminum tribromide (AlBr3) or dimethylaluminum bromide (Me2AlBr), resulting in a modest yield. Compound 4 was obtained by reacting compound 3 with methyllithium (CH3Li) in toluene. All compounds were characterized using infrared (IR) spectroscopy; 1H, 11B, 13C nuclear magnetic resonance (NMR) spectroscopy; and X-ray crystallography. X-ray structural studies of CabNAlBr2 (3) and CabNAlMe2 (4) (CabN = 2-dimethylaminomethyl-o-carboranyl) indicated that the aluminum atom was located at the center of a distorted tetrahedron. Crystal structures of CabNAlBr2 (3) [a = 8.9360(3) Å, b = 12.0358(9) Å, c = 14.7730(4) Å, α = β = γ = 90°] and CabNAlMe2 (4) [a = 8.9551(3) Å, b = 11.9126(9) Å, c = 14.7711(4) Å, α = β = γ = 90°] were obtained. The reactivity of aluminum complexes 3 and 4 with Lewis bases, such as H2O, pyridine, alkylamines, and arylamines, confirmed their rapid decomposition due to the strong Lewis acidity of aluminum metals.
Comprehensive Analysis of YTH Domain-Containing Genes, Encoding m6A Reader and Their Response to Temperature Stresses and Yersinia ruckeri Infection in Rainbow Trout (Oncorhynchus mykiss)
Authors: Yu Han , Gao Qinfeng , Wang Wen , Liu Dazhi , He Jinghong , Tian Yuan 
Published: May 2023

YTH domain-containing genes are important readers of N6-methyladenosine (m6A) modifications with ability to directly affect the fates of distinct RNAs in organisms. Despite their importance, little is known about YTH domain-containing genes in teleosts until now. In the present study, a total of 10 YTH domain-containing genes have been systematically identified and functionally characterized in rainbow trout (Oncorhynchus mykiss). According to the phylogenetic tree, gene structure and syntenic analysis, these YTH domain-containing genes could be classified into three evolutionary subclades, including YTHDF, YTHDC1 and YTHDC2. Of them, the copy number of OmDF1, OmDF2, OmDF3, and OmDC1 were duplicated or even triplicated in rainbow trout due to the salmonid-specific whole-genome duplication event. The three-dimensional protein structure analysis revealed that there were similar structures and the same amino acid residues that were associated with cage formation between humans and rainbow trout, implying their similar manners in binding to m6A modification. Additionally, the results of qPCR experiment indicated that the expression patterns of a few YTH domain-containing genes, especially OmDF1b, OmDF3a and OmDF3b, were significantly different in liver tissue of rainbow trout under four different temperatures (7 °C, 11 °C, 15 °C, and 19 °C). The expression levels of OmDF1a, OmDF1b and OmDC1a were obviously repressed in spleen tissue of rainbow trout at 24 h after Yersinia ruckeri infection, while increased expression was detected in OmDF3b. This study provides a systemic overview of YTH domain-containing genes in rainbow trout and reveals their biological roles in responses to temperature stress and bacterial infection.
Hybrid Vulture-Coordinated Multi-Robot Exploration: A Novel Algorithm for Optimization of Multi-Robot Exploration
Authors: Romeh Ali El , Mirjalili Seyedali , Gul Faiza 
Published: May 2023

Exploring unknown environments using multiple robots has numerous applications in various fields but remains a challenging task. This study proposes a novel hybrid optimization method called Hybrid Vulture-Coordinated Multi-Robot Exploration (HVCME), which combines Coordinated Multi-Robot Exploration (CME) and African Vultures Optimization Algorithm (AVOA) to optimize the construction of a finite map in multi-robot exploration. We compared HVCME with four other similar algorithms using three performance measures: run time, percentage of the explored area, and the number of times the method failed to complete a run. The experimental results show that HVCME outperforms the other four methods, demonstrating its effectiveness in optimizing the construction of a finite map in an unknown indoor environment.
Isolation, Identification and Molecular Mechanism Analysis of the Nematicidal Compound Spectinabilin from Newly Isolated Streptomyces sp. DT10
Authors: Sun Yuchen , Xie Jin , Tang Lihua , Odiba Arome Solomon , Chen Yanlu , Fang Wenxia , Wu Xiaogang , Wang Bin 
Published: May 2023

Plant parasitic nematodes (PPNs) are highly destructive and difficult to control, while conventional chemical nematicides are highly toxic and cause serious environmental pollution. Additionally, resistance to existing pesticides is becoming increasingly common. Biological control is the most promising method for the controlling of PPNs. Therefore, the screening of nematicidal microbial resources and the identification of natural products are of great significance and urgency for the environmentally friendly control of PPNs. In this study, the DT10 strain was isolated from wild moss samples and identified as Streptomyces sp. by morphological and molecular analysis. Using Caenorhabditis elegans as a model, the extract of DT10 was screened for nematicidal activity, which elicited 100% lethality. The active compound was isolated from the extracts of strain DT10 using silica gel column chromatography and semipreparative high-performance liquid chromatography (HPLC). The compound was identified as spectinabilin (chemical formula C28H31O6N) using liquid chromatography mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR). Spectinabilin exhibited a good nematicidal activity on C. elegans L1 worms, with a half-maximal inhibitory concentration (IC50) of 2.948 μg/mL at 24 h. The locomotive ability of C. elegans L4 worms was significantly reduced when treated with 40 μg/mL spectinabilin. Further analysis of spectinabilin against known nematicidal drug target genes in C. elegans showed that it acts via target(s) different from those of some currently used nematicidal drugs such as avermectin and phosphine thiazole. This is the first report on the nematicidal activity of spectinabilin on C. elegans and the southern root-knot nematode Meloidogyne incognita. These findings may pave the way for further research and application of spectinabilin as a potential biological nematicide.
Studi Komparasi Jaminan Barang Bergerak Dan Tidak Bergerak Dalam Gadai Perspektif Hukum Islam Dan Hukum Perdata
Authors: Aji Kurniawan , Anam Syaiful , Fauzi Rahman Ali 
Published: May 2023

This paper is the result of a comparative study to answer the following problem formulations: First, how is the concept of guaranteeing movable and immovable property in pawning the perspective of Islamic law and civil law. Second, how are the similarities and differences in the concept of movable and immovable property guarantees in the perspective of Islamic law and civil law pawning.
The type of research used is library. The research data was collected through the documentary method, namely by reading, recording, and collecting documents from several legal documents as well as the opinions of scholars and civil law experts that had been recorded relating to pawning law, especially to the object of pawn guarantees, which were then collected from the data. will be discussed and carried out comparative and qualitative analysis. These two methods are used to find conclusions from the similarities and differences between the two laws.
The results of this study conclude that, the similarities between Islamic law and civil law are in a generality of the permissibility of pawn contracts and the terms of collateral. While the difference between the two laws lies in the object of the pledged collateral. In Islam, all goods, both movable and immovable, are included as collateral for pledges. Whereas in civil law, collateral for pledged goods is only limited to movable goods that can be used as collateral for pledges, in the case of immovable property it is called a mortgage, and immovable property, especially land, in civil law is called mortgage.
Resiliencia en la gestión de riesgo para afrontar la vulnerabilidad en Tabasco
Authors: Hernández Castillo María Guadalupe , Pérez Alvarado Javier Antonio , Cruz Hernández Luis Enrique , Reyes Chablé Maritza , López De La Cruz Filogonio 
Published: May 2023

La vulnerabilidad se refiere a las características y las circunstancias de una comunidad, sistema o bien que los hacen susceptibles a los efectos dañinos de una amenaza (UNISDR, 2009). Esto afecta principalmente infraestructura, bienes y servicios esenciales o ya sea medios de sustento a gran escala o dimensión alta que supere la capacidad normal de un lugar o espacio para enfrentarse sin alguna ayuda. El objetivo de este documento es hacer una revisión documental sobre el panorama de riesgo y vulnerabilidad ante fenómenos naturales en el Estado de Tabasco, reflexionar acerca de la importancia y el reconocimiento de la Gestión Integral de Riesgo como herramienta para el Desarrollo Sostenible y la transformación social de condiciones generadoras de riesgo, que permite intervenir para evitarlos, reducirlos, así como de responder a sus efectos. Mediante una investigación documental se elaboró la búsqueda de información a través de la combinación de diversas palabras en bases de datos especializadas. Ante la emergente situación, es urgente hacer un estudio a profundidad que evalúe las condiciones de riesgo. Se considera importante trabajar en el foque de la gestión de riesgo desde una perspectiva colaborativa, socialización de los conocimientos y buenas prácticas a partir de los objetivos sustentados por el Marco Político y Normativo para fortalecer a su Institucionalidad, con la finalidad de ajustarse a los fenómenos y procesos generados por la variabilidad de las condiciones Climática. De esta forma estaremos trabajando por la ciudad resiliente ante los desastres, participando con acciones encaminadas al Desarrollo Sostenible.