bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered dynamic functional architecture in type 2 diabetes mellitus
Authors: Li Yifan , Li Mingrui , Zhao Kui , Wang Yan , Tan Xin , Qin Chunhong , Rao Yawen , Sun Zhizhong , Ge Limin , Cao Zidong , Liang Yi , Qiu Shijun 
Published: January 2023

IntroductionType 2 diabetes mellitus (T2DM) can accelerate cognitive decline and even dementia so that the underlying mechanism deserves further exploration. In the resting state, brain function is still changing dynamically. At present, it is still unknown whether the dynamic functional connectivity (dFC) between various brain regions is in a stable state. It is necessary to interpret brain changes from a new perspective, that is, the stability of brain architecture.MethodsIn this study, we used a fixed dynamic time scale to explore the stability of dynamic functional architecture in T2DM, then the dynamic effective connectivity (dEC) was used to further explain how information flows through dynamically fluctuating brain architecture in T2DM.ResultTwo brain regions with decreased stability were found including the right supra-marginal gyrus (SMG) and the right median cingulate gyrus (MCG) in T2DM subjects. The dEC variation has increased between the left inferior frontal gyrus (IFG) and the right MCG. The direction of causal flow is from the right MCG to the left IFG.ConclusionThe combination of stability and dEC can not only show the stability of dynamic functional architecture in brain but also reflect the fluidity of brain information, which is an innovative and interesting attempt in the field of neuroimaging. The changes of dynamic architecture in T2DM patients may present an innovative perspective and explanation for their cognitive decline.
The efficacy and safety of quinagolide in hyperprolactinemia treatment: A systematic review and meta-analysis
Authors: Zeng Yanyang , Huang Qingliang , Zou Yunzhi , Tan Jiacong , Zhou Wu , Li Meihua 
Published: January 2023

PurposeThree dopamine agonists [bromocriptine, cabergoline, and quinagolide (CV)] have been used for hyperprolactinemia treatment for decades. Several studies have reviewed the efficacy and safety of bromocriptine and cabergoline. However, no systematic review or meta-analysis has discussed the efficacy and safety of CV in hyperprolactinemia and prolactinoma treatment.MethodsFive medical databases (PubMed, Web of Science, Embase, Scopus, and Cochrane Library) were searched up to 9 May 2022 to identify studies related to CV and hyperprolactinemia. A meta-analysis was implemented by using a forest plot, funnel plot, sensitivity analysis, meta-regression, and Egger’s test via software R 4.0 and STATA 12.ResultsA total of 1,211 studies were retrieved from the five medical databases, and 33 studies consisting of 827 patients were finally included in the analysis. The pooled proportions of patients with prolactin concentration normalization and tumor reduction (&gt;50%) under CV treatment were 69% and 20%, respectively, with 95% confidence intervals of 61%–76% and 15%–28%, respectively. The pooled proportion of adverse effects was 13%, with a 95% confidence interval of 11%–16%.ConclusionOur study showed that CV is not less effective than cabergoline and bromocriptine in treating hyperprolactinemia, and the side effects were not significant. Hence, this drug could be considered an alternative first-line or rescue treatment in treating hyperprolactinemia in the future.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42022347750.
Relationships of adiponectin to regional adiposity, insulin sensitivity, serum lipids, and inflammatory markers in sedentary and endurance-trained Japanese young women
Authors: Guan Yaxin , Zuo Fan , Zhao Juan , Nian Xin , Shi Li , Xu Yushan , Huang Jingshan , Kazumi Tsutomu , Wu Bin 
Published: January 2023

IntroductionThis study aims to compare the differences in circulating adiponectin levels and their relationships to regional adiposity, insulin resistance, serum lipid, and inflammatory factors in young, healthy Japanese women with different physical activity statuses.MethodsAdipokines (adiponectin and leptin), full serum lipid, and inflammatory factors [white blood cell counts, C-reactive protein, tumor necrosis factor-α, tissue plasminogen activator inhibitor-1 (PAI-1)] were measured in 101 sedentary and 100 endurance-trained healthy Japanese women (aged 18–23 years). Insulin sensitivity was obtained through a quantitative insulin-sensitivity check index (QUICKI). Regional adiposity [trunk fat mass (TFM), lower-body fat mass (LFM), and arm fat mass (AFM)] was evaluated using the dual-energy X-ray absorptiometry method.ResultsNo significant difference was observed between the sedentary and trained women in terms of adiponectin levels. The LFM-to-TFM ratio and the high-density lipoprotein cholesterol (HDL-C) were the strong positive determinants for adiponectin in both groups. Triglyceride in the sedentary women was closely and negatively associated with adiponectin, as well as PAI-1 in the trained women. The QUICKI level was higher in the trained than sedentary women. However, no significant correlation between adiponectin and insulin sensitivity was detected in both groups. Furthermore, LFM was associated with a favorable lipid profile against cardiovascular diseases (CVDs) in the whole study cohort, but this association became insignificant when adiponectin was taken into account.ConclusionsThese findings suggest that adiponectin is primarily associated with regional adiposity and HDL-C regardless of insulin sensitivity and physical activity status in young, healthy women. The associations among adiponectin, lipid, and inflammatory factors are likely different in women with different physical activity statuses. The correlation of LFM and a favorable lipid profile against CVD and adiponectin is likely involved in this association.
Research on the pricing of PPP project ABS products based on the right of income of heating
Authors: Duan Zheng , Zhang Yifan 
Published: January 2023

Introduction: The Public-Private Partnership (PPP) model has the advantages of enhancing the efficiency of social infrastructure construction and reducing the risk of government liabilities, and has been widely used and developed in China. In the current securitization of PPP project assets, the question of how to price them is key to whether the Asset-backed Securities (ABS) products can be issued successfully.Methods: This study analyzes the pricing process and influencing factors of PPP project ABS in the context of PPP projects in China by collating the relevant literature on PPP project ABS products and collating the advantages and disadvantages of the static discounted cash flow (SCF), static spread (SS), and option-adjusted spread (OAS) methods. The study finds that the SCF and SS methods, primarily used in pricing PPP project ABS products, lack consideration of interest rate changes, early repayment rates, and multiple interest rate path options, leading to biased results. This study introduces the Monte Carlo simulation pricing method (MCSM) and conducts an empirical analysis based on the case of the Heating income right ABS of Huaxia Happiness PPP Project ABS.Results: It is concluded that the Monte Carlo simulation method can more flexibly and accurately price PPP project ABS products with revenue rights as the underlying assets.Discussion: This study has reference significance for the pricing of ABS products in future PPP projects and the construction of PPP projects in integrated energy service industrial parks, and can promote the development of new integrated energy service industrial parks, thereby helping to improve the energy consumption structure of enterprises in industrial parks, improve energy use efficiency, ensure the safety of energy use by enterprises, and further enhance the application of new energy by enterprises, thereby reducing their Greenhouse gas emissions.
An Approach to Correlate Chemical Pretreatment to Digestibility Through Biomass Characterization by SEM, FTIR and XRD
Authors: Sunkar Bindu , Bhukya Bhima 
Published: January 2023

A comprehensive study was carried out to assess the efficiency of different chemicals on the pretreatment of plant biomass, corn cobs. The efficiency was assessed based on its effect on subsequent hydrolysis of biomass for the conversion to fermentable sugars. Both alkali- and acid-based pretreatments were carried out under optimized conditions to avoid the formation of inhibitors and also to yield more sugars. Among the different chemicals used, 2% NaOH (w/v) was found to be effective with the delignification efficiency of 84.32%, and furthermore, the biomass saccharification efficiency was found to be 86.28% using 1.20% (v/v) HNO3 at 100°C for 90 min, whereas the pretreatment with other chemicals such as KOH, NaClO2, Na2SO3, and NH3 had significantly (p &lt; 0.05) low delignification, which ultimately reduced the saccharification efficiency. In acid–base-based pretreatment, 1.5% (v/v) HNO3 resulted in 63.42% delignification along with 68% digestion of hemicelluloses. The effect of pretreatment efficiency on digestibility was investigated by biomass characterization using SEM, FTIR, and XRD analyses before and after the treatment process. The imaging studies clearly indicated that 2% NaOH efficiently digested the complex matrix alignment and enhanced the surface area of the carbohydrate polymer which had shown a positive impact on the rate of hydrolysis. The study concludes that alkali-based pretreatment is the efficient and cost-viable technique for the effective valorization of corn cobs for the production of fermentable sugars which can be further converted to various valuable bioproducts.
The impact of digital transformation on low-carbon development of manufacturing
Authors: Lyu Yanfang , Zhang Leifeng , Wang Dong 
Published: January 2023

Objective: To measure the low-carbon development level and digital transformation degree of China’s manufacturing industry, and to examine the impact of digital transformation on low-carbon development.Methods: This paper uses Super Slack Based Measure (SBM) model and multi-regional input-output model to measure the low-carbon development level and digital transformation degree of 17 manufacturing industries in 30 provinces of China from 2012 to 2018, and uses high-dimensional fixed effect model and mediation model to study the impact of digital transformation on low-carbon development.Results: 1) During the study period, China’s manufacturing industry showed an upward trend in terms of low-carbon development level and digital transformation, but there were significant regional and industrial disparities. 2) Digital transformation can significantly promote the low-carbon development of manufacturing industry, which is still valid in the robustness test. 3) For sub-indicators, digital industrialization has the most obvious effect on the low-carbon development of manufacturing industry, and the improvement of digital development environment also has a positive impact on low-carbon development. 4) The heterogeneity analysis indicate that digital transformation has a greater impact on promoting low-carbon development of manufacturing in underdeveloped regions, and the positive effect is obvious in medium-low-energy-consuming industries, but not in high-energy-consuming industries. 5) The mechanism test shows that technological innovation is a channel for digital transformation to promote low-carbon development.Value: This paper provides empirical evidence for the environmental impact of digital transformation, and offers a scientific basis for relevant departments to formulate low-carbon development policies from the perspective of digital transformation.
Cytokine/chemokine levels in the CSF and serum of anti-NMDAR encephalitis: A systematic review and meta-analysis
Authors: Ma Yushan , Wang Jierui , Guo Shuo , Meng Zirui , Ren Yan , Xie Yi , Wang Minjin 
Published: January 2023

ObjectivesTo summarize the cytokine/chemokine levels of anti-N-methyl-Daspartate receptor encephalitis (NMDAR-E) and explore the potential role of these molecules and immune cells in the pathogenic mechanism.MethodsThe PubMed, Cochrane Library, Embase, and Web of Science databases were searched for various articles that assessed the concentrations of cytokines/chemokines in the unstimulated cerebrospinal fluid (CSF) or serum of patients with NMDAR-E in this systematic review and meta-analysis. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated by Stata17.0.ResultsA total of 19 articles were included in the systematic review from 260 candidate papers, and cytokine/chemokine levels reported in the CSF/serum were examined in each article. This meta-analysis included 17 eligible studies comprising 579 patients with NMDAR-E, 367 patients with noninflammatory neurological disorders, and 42 healthy controls from China, Spain, South Korea, Australia, Czechia, and Sweden. The results indicated that the levels of different cytokines interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-10, IL-13, IL-1β, IL-12, and IL-17 and chemokine C-X-C motif ligand (CXCL)10 in the CSF were significantly higher in NMDAR-E patients with a large effect size. In addition, B cell activating factor (BAFF), CXCL13, and interferon (IFN)-γ levels in the CSF were higher in NMDAR-E patients with a middle effect size. In contrast, levels of IL-2 and IL-4 in the CSF and CXCL13 and BAFF in the serum did not show a significant difference between cases and controls.ConclusionsThese analyses showed that the central immune response in NMDAR-E is a process that involves multiple immune cell interactions mediated by cytokines/chemokines, and T cells play an important role in the pathogenesis of immunity.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier (CRD42022342485).
Quantitative fluorescence resonance energy transfer-based immunoassay for activated complement C1s
Authors: Ye Jun , Xu Jie , Zhang Chuanmeng , Zhu Li , Xia Sheng 
Published: January 2023

ObjectivesC1s activation is associated with the pathogenesis of various diseases, indicating the potential value of C1s activation detection in clinic. Here we aimed to establish fluorescence resonance energy transfer (FRET)-based immunoassay for the quantitative detection of activated C1s in serum.MethodsFRET-based fluorogenic peptides, sensitive to the enzymatic activity of activated C1s, were prepared and labeled with the fluorophore ortho-aminobenzoic acid (Abz) and quencher 2,4-dinitrophenyl (Dnp), and then were further selected depending on its Kcat/Km value. C1s in the samples was captured and separated using anti-C1s-conjugated magnetic microbeads. Next, enzymatic activity of activated C1s in samples and standards was examined using fluorescent quenched substrate assays. Limit of detection (LOD), accuracy, precision, and specificity of FRET-based immunoassay were also investigated.ResultsThis method presented a linear quantification range for the enzymatic activity of activated C1s up to 10 μmol min-1 mL-1 and LOD of 0.096 μmol·min-1·mL-1 for serum samples. The recovery of the method was in the range of 90% ~ 110%. All CV values of the intra-analysis and inter-analysis of three levels in samples were less than 10%. The cross-reaction rates with C1r enzyme, MASP1, and MASP2 were less than 0.5%. No significant interferences were found with bilirubin (0.2 mg mL-1), Chyle (2000 FTU), and haemoglobin (5 mg mL-1), but anticoagulants (EDTA, citrate and heparin) inhibited the enzymatic ability of activated C1s. Thus, this established method can be used for the determination of active C1s in human serum samples in the concentration interval of 0.096-10.000 μmol min-1 mL-1.ConclusionsOne anti-C1s-based FRET immunoassay for activated C1s detection in serum samples were established, and it will be useful to explore the role of C1s activation in the pathogenesis, diagnosis and treatment in complement-related diseases.
Treatment with Helicobacter pylori-derived VacA attenuates allergic airway disease
Authors: Reuter Sebastian , Raspe Jonas , Uebner Hendrik , Contoyannis Alexandros , Pastille Eva , Westendorf Astrid M. , Caso Georgia C. , Cover Timothy L. , Müller Anne , Taube Christian 
Published: January 2023

BackgroundAsthma is an incurable heterogeneous disease with variations in clinical and underlying immunological phenotype. New approaches could help to support existing therapy concepts. Neonatal infection of mice with Helicobacter pylori or administration of H. pylori-derived extracts or molecules after birth have been shown to prevent the development of allergic airway disease later in life. This study evaluated the potential therapeutic efficacy of H. pylori vacuolating cytotoxin A (VacA) in allergic airway inflammation and investigated the underlying immunological mechanisms for its actions.MethodsMurine models of allergic airway diseases, and murine and human in vitro models were used.ResultsIn both an acute model and a therapeutic house dust mite model of allergic airway disease, treatment with H. pylori-derived VacA reduced several asthma hallmarks, including airway hyperresponsiveness, inflammation and goblet cell metaplasia. Flow cytometry and ELISA analyses revealed induction of tolerogenic dendritic cells (DC) and FoxP3 positive regulatory T cells (Tregs), and a shift in the composition of allergen-specific immunoglobulins. Depletion of Tregs during treatment with VacA reversed treatment-mediated suppression of allergic airway disease. Human monocyte derived DCs (moDC) that were exposed to VacA induced Tregs in co-cultured naïve autologous T cells, replicating key observations made in vivo.ConclusionH. pylori-derived VacA suppressed allergic airway inflammation via induction of Tregs in both allergic airway disease models. These data suggest that the immunomodulatory activity of VacA could potentially be exploited for the prevention and treatment of allergic airway disease.
Seizure burden and neuropsychological outcomes of new-onset refractory status epilepticus: Systematic review
Authors: Taraschenko Olga , Pavuluri Spriha , Schmidt Cynthia M. , Pulluru Yashwanth Reddy , Gupta Navnika 
Published: January 2023

BackgroundLong-term sequelae of the new onset refractory status epilepticus (NORSE) include the development of epilepsy, cognitive deficits, and behavioral disturbances. The prevalence of these complications has been previously highlighted in case reports and case series: however, their full scope has not been comprehensively assessed.MethodsWe conducted a systematic review of the literature (PROSPERO ID CRD42022361142) regarding neurological and functional outcomes of NORSE at 30 days or longer following discharge from the hospital. A systematic review protocol was developed using guidance from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).ResultsOf the 1,602 records for unique publications, 33 reports on adults and 52 reports on children met our inclusion criteria. They contained the description of 280 adults and 587 children of whom only 75.7 and 85% of patients, respectively had data on long-term follow-up. The mean age of adult and pediatric patients was 34.3 and 7.9 years, respectively; and the longest duration of follow up were 11 and 20 years, respectively. Seizure outcomes received major attention and were highlighted for 93.4 and 96.6% of the adult and pediatric NORSE patients, respectively. Seizures remained medically refractory in 41.1% of adults and 57.7% of children, while seizure freedom was achieved in only 26 and 23.3% of these patients, respectively. The long-term cognitive outcome data was provided for just 10.4% of the adult patients. In contrast, cognitive health data were supplied for 68.9% of the described children of whom 31.9% were moderately or severely disabled. Long-term functional outcomes assessed with various standardized scales were reported in 62.2 and 25.5% of the adults and children, respectively with majority of patients not being able to return to a pre-morbid level of functioning. New onset psychiatric disorders were reported in 3.3% of adults and 11.2% of children recovering from NORSE.ConclusionThese findings concur with previous observations that the majority of adult and pediatric patients continue to experience recurrent seizures and suffer from refractory epilepsy. Moderate to severe cognitive disability, loss of functional independence, and psychiatric disorders represent a hallmark of chronic NORSE signifying the major public health importance of this disorder.
Dosage consideration for transcranial direct current stimulation in post-stroke dysphagia: A systematic review and network meta-analysis
Authors: Xie Jianwei , Zhou Chiteng , Ngaruwenayo Gilbert , Wu Minghui , Jiang Xiaoyu , Li Xiaohan 
Published: January 2023

ObjectiveThis systematic review and network meta-analysis sought to determine the efficacy of different intensities of transcranial direct current stimulation (tDCS) in patients with dysphagia after stroke to improve swallowing function.MethodsRandomized-controlled trials (RCTs) of tDCS in post-stroke dysphagia were searched from Pubmed, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Service System (SinoMed), Wanfang database, and Chinese Scientific Journals Database (VIP) from databases' inception to June 22, 2022. Article screening, data extraction, and article quality evaluation were completed by 2 independent researchers. Network meta-analysis was performed using Stata.ResultsA final total of 20 studies involving 838 stroke patients were included. The included control interventions were sham tDCS and conventional therapy (CT). Network meta-analysis showed that 20 min of 1.2, 1.4, 1.5, 1.6, and 2 mA anodal tDCS and 30 min of 2 mA anodal tDCS significantly improved post-stroke dysphagia compared with CT (all P &lt; 0.05). In addition, 20 min of 1, 1.4, 1.6, and 2 mA anodal tDCS also significantly improved post-stroke dysphagia compared with sham tDCS (all P &lt; 0.05). Our results demonstrated that 20 min of stimulation at 1.4 mA was the optimal parameters for anodal tDCS and exhibited superior efficacy to CT [SMD = 1.08, 95% CI (0.46, 1.69)] and sham tDCS [SMD = 1.45, 95% CI (0.54, 2.36)].ConclusionDifferent durations and intensities of anodal tDCS are effective in improving post-stroke dysphagia. However, 20 min of tDCS at 1.4 mA may be the optimal regimen.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier CRD42022342506.