bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of the EVIBEC Learning Outcomes Framework to support the delivery of evidence-based practice curricula in health care professional programmes: a Codesign Approach
Authors: Redmond Catherine , Farrell Robin , Cunningham Caitriona , Dineen Andrea , Foley Shane , O`Donnell Deirdre , O`Reilly Sharleen , Stokes Diarmuid , O`Neill Emma 
Published: September 2023

Abstract
Background
All healthcare professional education programmes must adopt a systematic approach towards ensuring graduates achieve the competencies required to be an evidence-based practitioner. While a list of competencies for evidence-based practice exist, health care educators continue to struggle with effectively integrating these competencies into existing curriculum. The purpose of this project was to develop an open access cross-discipline, learning outcomes framework to support educators in integrating the teaching, learning and assessment required to ensure all graduates of health care professional programmes can achieve the necessary evidence-based practice competencies.
Methods
An interdisciplinary project team of 7 health care professions educators and a librarian completed a review of the health professions literature on the teaching and assessment of evidence-based practice. The literature coupled with the teams’ collective experiences in health professions evidence-based education and research were used to identify relevant teaching, learning and research frameworks to inform the project design. The guide and toolkit for experience-based co-design developed by the NHS Institute for Innovation and Improvement was adopted for this study. A four-step approach involving three online interactive and participatory co-design workshops and a national stakeholder validation workshop was designed. Students (n = 33), faculty (n = 12), and clinical educators (n = 15) contributed to the development and validation of the EVIBEC learning outcomes framework through this co-design approach.
Results
Through a rigorous, systematic co-design process the EVIBEC Learning Outcomes Framework was developed. This framework consists of a series of student-centred learning outcomes, aligned to EBP competencies, classified according to the 5 As of EBP and mapped to the cognitive levels of Bloom’s taxonomy. Associated learning activities for each step of EBP are suggested.
Conclusions
Co-design was an effective method to develop a learning outcomes framework and associated learning activities to support integration and delivery of evidence-based practice across health care professions education programmes. Furthermore, outcomes from the co-design workshops supported the use of a spiral curriculum design where knowledge and skills are introduced and revisited at increasing levels of complexity over time coupled with the use of active learning and assessment activities to deliver evidence-based practice curriculum.
The effect of social networking sites on resistance training behaviour among college students: application of a mixed model based on the theory of planned behaviour
Authors: Wei Wei , Su RongHai , Chen Lin , Meng Meng , Zheng Rongrong 
Published: September 2023

Abstract
Background
The purpose of this study is to explore the effect of social networking sites (SNS) on college students’ participation in resistance training, with a specific focus on the mediating role of planning and emotion in bridging the intention-behaviour gap.
Methods
Three hundred fifty-six college students (215 males and 141 females, with an average age of 21.37 ± 2.40 years) from 17 universities in China who regularly participate in resistance training were surveyed via questionnaires. The data was analysed using the Maximum Likelihood Estimation (MLE) in AMOS 20.0, and the planned behaviour mixed model was tested using a structural equation model.
Results
Three main findings emerged from the study: 1) SNS had a positive effect on college students' participation in resistance training; 2) Intention and behaviour towards resistance training among college students were influenced by planning and positive emotion as mediators; 3) College students' participation in resistance training is positively affected by rational cognition.
Conclusions
The mixed model of planned behaviour examines how SNS influences college students' intentions and behaviour toward resistance training. By combining the advantages of rational thinking with basic emotional instincts, this model provides a more accurate prediction of college students' intentions and behaviours in resistance training.
Advanced lung cancer inflammation index is associated with mortality in peritoneal dialysis patients
Authors: Ren Zhouhao , Wu Jiaying , Shen Shuijuan 
Published: September 2023

Abstract
Background
There is still a very high morbidity and mortality rate for patients undergoing peritoneal dialysis (PD). The advanced lung cancer inflammation index (ALI) has been demonstrated to be associated with prognosis in multiple types of cancers. Similar to cancer, systemic chronic low-grade inflammation is one of the distinguishing features of PD patients. Therefore, we aimed to investigate the relationship between ALI and all-cause and cardiovascular mortality in PD patients.
Methods
277 patients who started PD at Shaoxing People's Hospital between 1 January 2013 and 31 December 2020 were recruited and followed up until 1 July 2023. The dose-response relationship between ALI and mortality was described by restricted cubic splines. Receiver operating characteristic (ROC) analysis was performed and the area under the curve (AUC) was calculated to determine the predictive power of ALI for all- cause mortality and CVD mortality. Kaplan-Meier curves and multivariate cox regression analyses were used to assess the association between ALI and all-cause mortality and cardiovascular mortality.
Result
During the median follow-up of 40.50 months (interquartile range, 26.42~59.77 months), a total of 55 patients died and 31 of them died due to cardiovascular disease. Kaplan-Meier curves showed that patients in the low ALI group had significantly lower cumulative survival rate and cardiovascular cumulative survival rate than those in the high ALI group (all P < 0.001). After correcting for confounders, the risk of all-cause mortality and cardiovascular death was significantly higher in the low ALI group than in the high ALI group [hazard ratio (HR) 1.944, 95% confidence interval (Cl) 1.068~3.540, P = 0.030, and HR 2.672, 95% Cl 1.188~6.009, P = 0.017, respectively].
Conclusion
A lower ALI is an independent risk factor for all-cause mortality and cardiovascular mortality in PD patients. ALI may be an effective indicator for predicting outcomes in PD patients.
Association Between Serum Gamma-Glutamyl Transferase and Alkaline Phosphatase with Presence of Premature Coronary Artery Disease: Findings from Khuzestan Comprehensive Health Study (KCHS)
Authors: Khaboushan Alireza Soltani , Masoudkabir Farzad , Jalali Arash , Vasheghani-Farahani Ali , Mohammadi Zahra , Mard Ali , Rahimi Zahra , Hashemi Farnaz , Malihi Reza , Danehchin Leila , Abolnezhadian Farhad , Paridar Yousef , Mir-Nasseri Mohammad Mahdi , Cheraghian Bahman , Shayesteh Ali Akbar , Poustchi Hossein 
Published: September 2023

Abstract
Background
Coronary artery disease has remained the leading cause of death worldwide. Premature coronary artery disease (PCAD) is defined as the incidence of coronary artery disease in males ≤ 45 and females ≤ 55. This study aimed to investigate the association between the concentrations of gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) with the presence of PCAD for the first time in a large general population in a developing country.
Methods
A total of 20,542 from the Khuzestan Comprehensive Health Study participants were entered into the study based on the inclusion and exclusion criteria. The association of the GGT and ALP levels with the presence of PCAD was analyzed with multiple logistic regression models adjusted for gender, dyslipidemia, triglyceride concentration, cigarette smoking, opium consumption, hypertension, diabetes mellitus, and age. Moreover, the receiver operating characteristic (ROC) was used to assess the predictive power of GGT and ALP for PCAD.
Results
While in univariate analyses both ALP and GGT were significantly associated with the presence of PCAD [GGT: odds ratio (OR), 1.008; 95% confidence interval (CI), 1.005–1.011; p-value < 0.0001; ALP: OR, 1.003; CI, 1.002–1.004; p-value < 0.0001], after adjusting for confounders, the associations were no longer significant (GGT p-value = 0.177; ALP p-value = 0.963). However, the addition of the GGT to the conventional cardiovascular risk factors improved the predictive value of the model for the presence of PCAD in females (p-value < 0.05).
Conclusions
In conclusion, although ALP showed no independent association with PCAD, adding GGT to conventional cardiovascular risk factors could significantly improve the prediction of PCAD in female participants.
Expression and Application of Computer Image Technology in Visual Communication Design in Fashion Design
Authors: Wu Wei , Li Kui 
Published: September 2023

Abstract
After years of development, clothing design is full of artistic sense, and clothing has developed from traditional clothing to a kind of artistic clothing. The use of Visual Communication (VC) design in clothing design can creatively combine words, symbols, and graphics, but it is difficult to deal with graphics in traditional clothing design. In this article, computer image technology was applied to VC design in clothing design, and the effect of clothing design was improved through the accurate processing of clothing graphics and symbols. This article compared traditional VC design and VC design based on computer image technology in clothing design. The experimental results showed that the average VC effect of traditional VC design and VC design based on computer image technology was 75.98% and 83.72% respectively in life clothing. In fashion clothing, the average VC effect of traditional VC design and VC design based on computer image technology was 76.58% and 85.66% respectively. Therefore, VC design in clothing design using computer image technology can improve the VC effect.
The Effect of Pterygium on Front and Back Corneal Astigmatism and Aberrations in Natural-Light and Low-Light Conditions
Authors: xu weiwei , li xia 
Published: September 2023

Abstract
Background
To investigate the effect of different sizes of pteryium on the front and back corneal topography, corneal refractive changes and aberrations in natural-light and low-light conditions.
Methods
Sixty subjects with unilateral primary nasal pterygium were enrolled in this study. All the patients’ uncorrected, best spectacle-corrected visual acuities, corneal topographic aberration data in 3mm and 7mm areas were collected. The pterygia sizes were evaluated by the slit-lamp photography and Sirius Scheimpflug Analyzer.
Results
The front topographic astigmatism values, corneal total abbertions, and higher-order aberrations in 3mm and 7mm areas were higher in the pterygia group than those in the control group. The ptergia horizontal length and thickness were moderately to strongly correlated with astigmatism and RMS of aberrations, while pterygia vertical length showed no or just mild correlation with the cornCompared to the readings in 3mm area, the front and back corneal astigmatism and aberrations were larger in 7mm area.
Conclusions
Pterygia led to visual impairment by inducing astigmatism and aberrations. In low-light condition, the visual function were worse because of increased corneal astigmatism values and aberrations.
Emerging spectrum of DOCK8 deficiency in children and challenges associated with providing treatment: experience from a tertiary referral centre in India
Authors: ganesan kavitha , duraisamy suresh , nair anupama , muthukumar vijayshree , swaminathan venkateswaran vellaichamy , jayakumar indira , krishna vidya , UPPULURI RAMYA , raj revathi 
Published: September 2023

Abstract
The study describes the course of children with DOCK8 deficiency, their stormy clinical course, discrete infection pattern, and challenges during the treatment. The retrospective study included children up to 18 years of age diagnosed to have genetically proven DOCK8 deficiency from January 2013 to January 2023. A total of nine children were included, with a median age of five years. Clinical presentations included eczema (2/9), viral infections (4/9), recurrent sinopulmonary infections (3/9), impetigo (2/9), autoimmune hemolytic anemia (1/9) and Epstein-Barr virus driven malignancy (1/9). Other infections noted were molluscum contagiosum in two children, cytomegalovirus colitis in one child, and recurrent Klebsiella pneumoniae meningitis. The outcomes of hematopoietic stem cell transplantation (HSCT) remained poor (n=5, three haploidentical HSCT, one each matched family and unrelated donor HSCT), due to early and refractory viral reactivation, with 17,00,000 copies of cytomegalovirus in one child and 8,53,95,600 copies of adenovirus in another child. Secondary late graft failure was noted in one child, two years following a matched sibling donor HSCT. The one who underwent a matched unrelated donor HSCT was doing well and was infection free. The clinical course without HSCT had been stormy, as seen in a child with Burkitt's lymphoma, who succumbed to refractory cytomegaloviral meningoencephalitis despite being in remission following chemotherapy. DOCK8 deficiency patients are included in the Hyper IgE syndrome spectrum. HSCT poses significant challenges in these children with refractory viral infections. Collaborative work and research are required to decide the optimal care for these children to guide better treatment outcomes.
Biopesticidal Activity for Controlling Root Rot and Root Knot Infection of Green Beans under Natural Field Conditions Utilizing Biowastes
Authors: Nawwar Galal , Othman Hoda Sabry , Abdel-Kader Mokhtar , El-Mougy Nehal S. 
Published: September 2023

Abstract
The current study investigates using of alkaline black liquor (ABL), a byproduct of rice straw pulping, to create a bio-active formulation that can inhibit the growth of soilborne plant pathogens. ABL was first treated to precipitate lignin, silica, and fatty acids as a calcium complex (Ca-LSF). The resulting effluent was used to digest chicken feathers under mild conditions. The resulting protein hydrolysate was added to Ca-LSF complex affording a novel formulation to be evaluated against soilborne pathogenic fungi Fusarium oxysporum, Fusarium solani, Rhizoctonia solani, and Sclerotium rolfsii, as well as the nematode Meloidogyne incognita, the causal organisms of wilt, root rot and root knot diseases. The prepared formulation showed strong inhibitory effect against R. solaniand affected viability of M. incognita. This effect increased with increasing concentration, up to 4%, which completely inhibited fungal growth. It was also examined under field conditions, where it reduced root rot and root knot infection. Application of this formulation as seed dressing showed higher efficacy against root rot and root knot infection than its soil drench treatment, although both treatments were superior to untreated control. The presented safe, cost-effective, and eco-friendly formulation could be used to control a wide range of soilborne plant pathogens.
Middle East North Africa (MENA) and Indian Thar desert dust storms pathway as game changer of Phosphorus depositional pattern in Asia's largest Grassland
Authors: sharma Seema , Dey Rupak , THAKKAR MAHESH , Sarangi Ranjit , Chowdhury Abhiroop , Naz Aliya 
Published: September 2023

Abstract
Dust particles make up almost all of the atmospheric phosphorus, which accounts for 82% of the total phosphorus in the world. Phosphorus (P) is an important nutrient for terrestrial ecosystems, playing a critical role in influencing primary productivity and hence ecosystem dynamics. The deposition of airborne dust, particularly from arid and semi-arid regions, has been recognized as a significant source of phosphorus input in distant ecosystems. The study area, the Banni Plains, is a semi-arid ecosystem with a unique geological history, that has suffered from degradation due to varied natural and anthropogenic reasons. It is located in arid tract of western India (23º 19' to 23º52' N latitude and 68º 56' to 70º32' E longitude).Soil samples were collected from 10*10 km grid locations in the grassland before, after 48 hours, and 20 days after a cyclonic storm, Biporjoy, which hit the region in June, 2023. Statistical analyses (Shapiro-Wilk normality and Kruskalwallis H test) were performed on the data to assess the differences in phosphorus concentrations among the phases. To examine the long-range transport of dust-borne phosphorus and its subsequent deposition in the target grassland, we employed an interdisciplinary approach that integrated satellite imagery and ground-based measurements. Spatial and temporal variations in dust emissions were assessed using satellite remote sensing data, while ground truthing was done for phosphorus content analysis using standard protocols. The aerosol data from MERRA-2 for the past 40 years were used to examine the relationship between aerosol concentrations and wind direction and speed. Our findings reveal that the Middle East, North Africa, and Thar Deserts significantly contribute to the phosphorus deposition in the target grassland during specific seasons. The SW cyclone ‘Biporjoy’ that followed the same track of aerosols loading (MENA) had a landfall on this zone (June 16, 2023) affected the P depositional patterns. The pre cyclone, post cyclone and 20 DAC (Days after Cyclone), had AP values 20.15, 20.54 and 24.06 respectively. However, TP values were 45.81 ± SE = 1.73, 60.95 ± SE = 1.39 and 61.98 ± SE = 1.40 respectively. The highest TP values was in phase 3 (20 DAC phase) 61.89 ± SE = 1.40. Dust storms and other atmospheric circulation patterns were found to play a pivotal role in facilitating the long-range transport of phosphorus-laden dust particles from these source regions to the target grassland. Ultimately, our research contributes to the broader understanding of global nutrient cycling and land-air interactions, enabling informed decision-making for the conservation and sustainable management of terrestrial ecosystems.
Processing characteristics and loading principle on micro blanking of cavitation jet
Authors: Wang Yun , Zhu Cong , Li Fuzhu , Yu Chao , Chen Shijian , Wu Jingyi 
Published: September 2023

Abstract

This study proposes a new technology of flexible micro blanking with cavitation jet to improve the quality of micro blanking parts. We simulated the cavitation jet, obtained the change of its meteorological volume fraction, and verified the high- pressure phenomenon caused by cavitation collapse, which is used to achieve processing. Then, we investigated the blanking form ability of cavitation jet on T2 copper foils to cope with different shapes. The impact of the incident pressure of cavitation jet and targeted distance on the micro blanking form ability is studied, and the experimental results are correlated with the simulation. Also, we observed a linear relation between the critical blanking thickness and blanking size of T2 copper foil. Through the characterization of the experimental results, it is found that the internal stress of the regular polygon-shaped blanking parts is unevenly distributed along the blanking contour during processing, which is easy to cause the material to tear and produce defects like flaws and incomplete forming. On the other hand, the internal stresses of the circular blanking parts are evenly distributed along the blanking contour, which shows that the blanking forming has good quality. This processing technology is different from traditional plastic micro blanking processing, the cut edge morphology of micro blanking parts under cavitation jet technology is mainly bending and pulling, without obvious shearing marks. Under moderate incident pressure, the cut edge of the blanking part has few pulling marks and small burrs, and has good and uniform blanking quality.
Semi-Empirical Model for Henry’s Law Constant of Noble Gases in Molten Salts
Authors: Lee Kyoung , Williams Wesley , Mcfarlane Joanna , Kropaczek Dave , de Wet Dane 
Published: September 2023

Abstract
Henry's law constant, which describes the proportionality of dissolved gas to partial pressure of free gas in liquid--gas equilibrium systems, can also be applied to mass transport applications. In this work, we investigated an approach for determining the solubility of noble gases in a molten salt liquid utilizing the equilibrium concept of Henry's gas constant. Henry's gas constant is described as a mathematical function dependent on the van der Waals radius of the noble gas and the temperature of the molten salt. The alteration in Gibbs free energy encompasses contributions from both surface and volume energies. Enthalpy and entropy are deduced from these surface and volume energies in the Gibbs free energy formulation. A comparative analysis was conducted between the conventional method and our proposed model. Moreover, useful chemical properties can be determined from examination of surface and volume energies. Our findings provide an accurate and general theory of Gibbs free energy that can be validated experimentally based on the model proposed herein. This work unifies the prediction of Henry gas constant and subsequently the entropy and enthalpy calculation for noble gases in a molten salt solution to a single functional form using van der Waals radius of the gas and temperature of the system. This functional form is then used to perform a multiple regression method to find two parameters corresponding to the surface energy and volume energy. These two parameters are consistent between all combinations of noble gas and molten salt.
Targeting Human progesterone receptor (PR), through Pharmacophore- based screening and molecular simulation revealed potent inhibitors against breast cancer
Authors: Shahab Muhammad , Ziyu Peng , Zheng Guojun , Almaary Khalid S. , Wondmie Gezahign Fentahun , Bouhrhia Mohammed 
Published: September 2023

Abstract
Breast cancer, the prevailing malignant tumor among women, is linked to progesterone and its receptor (PR) in both tumorigenesis and treatment responsiveness. Despite thorough investigation, the precise molecular mechanisms of progesterone in breast cancer remain unclear. The human progesterone receptor (PR) serves as an essential therapeutic target for breast cancer treatment, warranting the rapid design of small molecule therapeutics that can effectively inhibit HPR. By employing cutting-edge computational techniques like molecular screening, simulation, and free energy calculation, the process of identifying potential lead molecules from natural products has been significantly expedited. In this study, we employed pharmacophore-based virtual screening and molecular simulations to identify natural product-based inhibitors of human progesterone receptor (PR) in breast cancer treatment. High-throughput molecular screening of Traditional Chinese Medicine (TCM) and zinc databases was performed, leading to the identification of potential lead compounds. The analysis of binding modes for the top two compounds from each database provides valuable structural insights into the inhibition of HPR for breast cancer treatment. The top four hits exhibited enhanced stability and compactness compared to the reference compound. In conclusion, our study provides valuable insights for identifying and refining lead compounds as HPR inhibitors.