bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbonate apatite: effect of serum and impact on the cellular proteome
Authors: Islam Rowshan Ara , Ibnat Nabilah , Ashaie Maeirah Afzal , Abidin Syafiq Asnawi Zainal , Chowdhury Ezharul Hoque 
Published: September 2023

AbstractCarbonate apatite (CA) is a synthetic derivative of hydroxyapatite, which we have been exploring as a drug delivery nanocarrier in the context of cancer in vitro and in vivo. This nanocarrier showed great potential delivering anti-cancer drugs, plasmids containing tumour suppressor genes and siRNAs against oncogenes in pre-clinical models. We compared here two formulations of CA—the low-Ca2+ CA (made with 4 mM Ca2+) used for in vitro studies in cell lines and the high-Ca2+ CA (made with 40 mM Ca2+) used in mouse models—in terms of protein corona formed with different concentrations of serum in vivo and in vitro. The 10-fold more Ca2+ in high-Ca2+ CA helped produce enough particles in an injectable volume for in vivo delivery of therapeutics. Both formulations made particles of similar size, but their composition differed slightly in terms of Na and Mg content. In serum-containing media, the size of the particles was dependent on the serum concentration. The protein corona around both formulations was almost similar and included albumin, fetuin, haemoglobin, and immunoglobulins. CA was not cytotoxic, and instead an increased expression of ribosomal machinery and glycolytic and cytoskeletal proteins was observed, which promoted translation, growth, and proliferation in cancer cells.
A Novel Free-Gliding Ski Tribometer for Quantification of Ski–Snow Friction with High Precision
Authors: Sandberg Joakim , Kalliorinne Kalle , Hindér Gustav , Holmberg Hans-Christer , Almqvist Andreas , Larsson Roland 
Published: September 2023

AbstractThe nature of snow and the ever-changing environment makes measuring friction on snow and ice challenging. Additionally, due to the low friction involved, the equipment used must exhibit high sensitivity. Previous investigations of ski–snow friction have ranged from small-scale model experiments performed in the laboratory to experiments with full-sized skis outdoors. However, few have been conducted under conditions similar to those encountered during actual skiing. Here, we present a novel sled tribometer which provides highly reproducible coefficient of friction (COF) values for full-sized skis gliding at relevant speeds (approximately 5.9 m/s) in a controlled indoor environment. The relative standard deviation (RSD) of the COF is as low as 0.5%. The continuous recording of velocity allows for innovative investigations into COF variations when skis are permitted to free-glide in a natural setting. Different methods of analysing the results are presented which shows that the precision is not a single number, but a function of the range of velocities over which the average COF is calculated.
Graphical abstract
Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model by suppressing proinflammatory cytokines and elevating neurotransmitter release
Authors: Aktar Sharmin , Ferdousi Farhana , Kondo Shinji , Kagawa Tamami , Isoda Hiroko 
Published: September 2023

AbstractIn recent years, exploring natural compounds with functional properties to ameliorate aging-associated cognitive decline has become a research priority to ensure healthy aging. In the present study, we investigated the effects of Trigonelline (TG), a plant alkaloid, on memory and spatial learning in 16-week-old senescence-accelerated mouse model SAMP8 using an integrated approach for cognitive and molecular biology aspects. After 30 days of oral administration of TG at the dose of 5 mg/kg/day, the mice were trained in Morris Water Maze task. TG-treated SAMP8 mice exhibited significant improvement in the parameters of escape latency, distance moved, and annulus crossing index. Next, we performed a whole-genome transcriptome profiling of the mouse hippocampus using microarrays. Gene ontology analyses showed that a wide range of biological processes, including nervous system development, mitochondrial function, ATP synthesis, and several signaling pathways related to inflammation, autophagy, and neurotransmitter release, were significantly enriched in TG-treated SAMP8 compared to nontreated. Further, a nonlinear dimensionality reduction technique, Uniform Manifold Approximation and Projection (UMAP), was applied to identify clusters of functions that revealed TG primarily regulated pathways related to inflammation, followed by those involved in neurotransmitter release. In addition, a protein–protein interaction network analysis indicated that TG may exert its biological effects through negatively modulating Traf6-mediated NF-κB activation. Finally, ELISA test showed that TG treatment significantly decreased proinflammatory cytokines- TNFα and IL6 and increased neurotransmitters- dopamine, noradrenaline, and serotonin in mouse hippocampus. Altogether, our integrated bio-cognitive approach highlights the potential of TG in alleviating age-related memory and spatial impairment.
Integrated Information is not Causation: Why Integrated Information Theory’s Causal Structures do not Beat Causal Reductionism
Authors: Sánchez-Cañizares Javier 
Published: September 2023

AbstractIn a recent work (Grasso et al., 2021), practitioners of the Integrated Information Theory (IIT) claim to have overcome the weaknesses of causal reductionism in producing a coherent account of causation, as causal reductionism would blatantly conflate causation with prediction and could not answer the question of ‘what caused what.’ In this paper, I reject such a dismissal of causal reductionism since IIT anti-reductionists misunderstand the reductionist stance. The reductionists can still invoke a causal account stemming from the causal power of the universe’s basic units and interactions that, eventually, may lead to structures supporting integrated information. Additionally, I claim that the IIT-inspired misunderstanding of causal reductionism originates from the former’s metaphysical deficit, conflating information with causation. However, as a possible way out, if IIT is complemented with a deeper metaphysical ground, such as nested hylomorphism, an improved argument against causal reductionism can be made to work by invoking formal causality as the ultimate cause of integration in natural systems.
Fixed Combination for the Treatment of Dyslipidaemia
Authors: Ferri Nicola , Ruscica Massimiliano , Santos Raul D. , Corsini Alberto 
Published: September 2023

Abstract
Purpose of Review
It is clear from epidemiological studies that patients at high and very-high risk of atherosclerotic cardiovascular diseases (ASCVD) risk do not reach lipid guideline–recommended targets. Thus, fixed-dose combinations of statins/ezetimibe, bempedoic acid/ezetimibe and statins/fibrates may represent a further armamentarium in the field of lipid-lowering approaches in these individuals.

Recent Findings
The combination therapy of moderate-intensity statin with ezetimibe is not inferior to high-intensity statin monotherapy in reducing cardiovascular outcomes. Drug discontinuation or dose reduction is inferior with fixed-dose combination. The fixed-dose combination of bempedoic acid with ezetimibe is superior to bempedoic acid in monotherapy in lowering LDL-C and in reducing high-sensitivity C-reactive protein concentrations. The combination fenofibrate with atorvastatin is superior to monotherapies in lowering triglycerides.

Summary
Lipid-lowering fixed-dose combinations may guarantee a higher therapy adherence, representing a better approach to control plasma lipids and thus ameliorate ASCVD burden. Additional studies will define the advantages on cardiovascular outcomes in high and very high-risk patients.
Recent Advances in CRISPR/Cas9 Delivery Approaches for Therapeutic Gene Editing of Stem Cells
Authors: Lotfi Malihe , Morshedi Rad Dorsa , Mashhadi Samaneh Sharif , Ashouri Atefeh , Mojarrad Majid , Mozaffari-Jovin Sina , Farrokhi Shima , Hashemi Maryam , Lotfi Marzieh , Ebrahimi Warkiani Majid , Abbaszadegan Mohammad Reza 
Published: September 2023

Abstract
Rapid advancement in genome editing technologies has provided new promises for treating neoplasia, cardiovascular, neurodegenerative, and monogenic disorders. Recently, the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system has emerged as a powerful gene editing tool offering advantages, including high editing efficiency and low cost over the conventional approaches. Human pluripotent stem cells (hPSCs), with their great proliferation and differentiation potential into different cell types, have been exploited in stem cell-based therapy. The potential of hPSCs and the capabilities of CRISPR/Cas9 genome editing has been paradigm-shifting in medical genetics for over two decades. Since hPSCs are categorized as hard-to-transfect cells, there is a critical demand to develop an appropriate and effective approach for CRISPR/Cas9 delivery into these cells. This review focuses on various strategies for CRISPR/Cas9 delivery in stem cells.

Graphical Abstract
Lethal complication of a rare cardiac tumor
Authors: Siegel S. , Claus L. , Kamphausen T. , Feld K. 
Published: September 2023

AbstractCardiac tumors, especially malignant ones, are rare and diagnosis is challenging since symptoms manifest late and are often non-specific. Achieving a histological diagnosis prior to resection is also difficult because biopsies often fail to yield conclusive results. Due to the low frequency, no standard treatment protocol exists and the prognosis is poor. We present a case of a cardiac sarcoma, which was found during an autopsy performed with regard to medical malpractice, because the patient died due to a medical intervention. To report cases like this is important to gain more knowledge about possible complications regarding rare diseases.
Need satisfaction and organizational citizenship behaviour towards the organization. A process-oriented approach
Authors: Spanouli Andromachi , Bidee Jemima , Hofmans Joeri 
Published: September 2023

AbstractAlthough citizenship behaviours can vary for each individual over the course of months, weeks, or even days, research has predominantly looked at this concept through a static lens. In this paper, we combine a between- and within-person level approach in examining the circumstances under which people engage in organizational citizenship behaviours towards the organization (OCBO). Drawing from conservation of resources theory, we tested how fluctuations in resources, represented by need satisfaction, relate to fluctuations in OCBO at three different levels: between individuals, within individuals, as well as over time. Seventy-three volunteers working in holiday camps filled out a daily diary study for eight consecutive working days, measuring OCBO and need satisfaction (N = 439). Multilevel regression analyses revealed that individuals who were on average higher in need satisfaction performed on average more OCBOs. At the within-person level, higher momentary levels of need satisfaction related to higher levels of OCBO, whereas over time, changes in need satisfaction were positively associated to changes in OCBO. Our focus on the evolvement of OCBOs over individuals and over time gives us a more complete account of not only who engages in OCBO but also under which circumstances, an understanding that comes with important implications both for theory and practice.
Lithostratigraphy of the Paleogene Deccan Intra-, Intertrappeans of the Saurashtra, Western India and their Prevalence in Large Igneous Provinces
Authors: Patel Satish J. , Shah Nishi H. 
Published: September 2023

Abstract
The periphery of the Deccan Volcanic Province (DVP) of India comprises sedimentary succession deposited during the waning phase of volcanism across the Cretaceous-Paleogene boundary which preserves the continental biota. The Saurashtra Peninsula, a part of the Saurashtra-Kachchh sub-province, exposes thick intertrappean sedimentary successions, systematically described to understand the stratigraphic framework with respect to the lava flows and their geographic distinctness. The thickness of the exposed sections is measured, and contact and continuities are marked, revealing two different, small geographically isolated but adjacent, coeval basins, named the Ninama Basin and Chotila Basin, initially comprising fine grain sediment, followed by thick conspicuous limestone and chert deposits respectively. Formal lithostratigraphic unit names are proposed for both basins: Ninama Basin comprises lithic arenite, fossiliferous limestone, bedded siltstone, mudstone and claystone, and is divided into Sukhbhadar Formation and Ninama Limestone. Chotila Basin comprises calcareous sandstone, bedded siltstone, silty shale and mudstone, claystone and chert divided into Rangpar Formation, Chotila Chert, and Bamanbor Formation. Lithology and palynofossil evidence suggest restricted continental environments with varying salinities during the Paleogene.
Timing of Garnet Growth in Granulites from Southern India: Insights from Zircon-monazite-garnet REE Partition Modeling
Authors: Sajna S. , Tomson J.K. , Dev J. Amal , Sorcar Nilanjana 
Published: September 2023

Abstract
The Nagercoil block, which is situated at the southernmost part of the Southern Granulite Terrane of south India, is dominantly comprised of garnet-bearing I-type massive charnockites. These charnockites preserve imprints of two major thermal events timed at Palaeoproterozoic (∼2.0-1.9 Ga) and Neoproterozoic (∼550 Ma). However, there is a lack of understanding on correlating the growth and stabilization of garnets within these charnockites, corresponding to these events. In the present study, rare earth element-based partition modeling between garnet and age-constrained accessory phases such as zircon and monazite is carried out to identify the exact timing of garnet formation in a representative sample from the area. U-Pb dating of zircon cores constrains the timing of protolith emplacement at ∼2.0 Ga and metamorphism at ∼550 Ma from zircon rims and monazites. REE modeling of zircon and monazite from these age domains suggests an equilibrium relation between the Neoproterozoic zircon rims and monazites, while the Palaeoproterozoic zircon cores are not in equilibrium with garnet. These results suggest that the formation of garnets in the Nagercoil charnockites is in response to the Neoproterozoic metamorphism recorded in the terrane associated with the final stage of the Gondwana supercontinent assembly.
Evaluation of Maturity (Late Diagenesis) in Source Rocks of Jaisalmer Basin in Rajasthan, India using 57Fe Mössbauer Spectroscopy
Authors: Ram Sahi 
Published: September 2023

Abstract
The potential of a source rock for hydrocarbon generation depends on several factors such as the amount, type and maturity level of the organic matter present in it as well as the redox conditions in which the sediments containing the source rocks were deposited. Organic-rich sediments deposited in reducing environment have better prospects for a good quality source rock as compared to those deposited in oxidizing environments. The information about the oxidizing/reducing environment at the time of deposition can be obtained from the presence or absence of certain iron-bearing minerals in sediments. The presence of oxide minerals goethite (α-FeOOH) and/or hematite (α-Fe2O3) indicates that sediments were deposited in an oxidizing environment. Therefore the study of iron-bearing minerals in sediments can be used to understand the qualities of the source rocks.
Sedimentary samples were collected from different depths of three wells BT-3, DND-1 and LNR-1 located in different structures of the Jaisalmer basin were investigated to understand the chemical state of iron by using Mössbauer spectroscopy. In most of the samples, iron was found mainly in the form of pyrite (FeS2), siderite (Fe, Mg) CO3, 2:1 layer silicates in high spin Fe3+ and high spin Fe2+ state and (Ca, Fe, Mg) carbonates. In the samples from Lathi and Shumarwali formations that belong to the lower Jurassic and Triassic sequences, α-Fe2O3 (hematite) was indeed observed. It was present in a narrow sedimentary depth interval in the wells BT-3 and DND-1 and in a much broader thickness in well LNR-1. The other sedimentary sequences younger than the Lower Jurassic sediments have not shown the presence of any oxide mineral.
The present study indicates that oxidizing environment was present in the entire basin in the Lower Jurassic era at least for some duration. However, the degree of oxidation was not uniform as evident from the distribution pattern of iron oxide mineral (α-Fe2O3). Mössbauer studies of source rocks can also be used as a fingerprint to get information about the thermal history (Palaeo-temperature) of sedimentary sequence which is crucial in hydrocarbon prospecting.
Sedimentary Parameters and Evolution of the Outwash Plain Deposits during Late Holocene in the Gangotri Glacier Region, Garhwal Himalaya, India
Authors: Singh Anoop Kumar , Dubey Chetan Anand , Singh Dhruv Sen , Kumar Dhirendra , Sharma Rajveer 
Published: September 2023

Abstract
Gangotri glacier located in the Uttarkashi District of the Garhwal Himalaya, is one of the longest valley glacier. It exhibits Lateral Moraines (LM), Recessional Moraines (RM), Kame Terraces (KT) and Outwash Plains (OWP) as important landforms. The sediments coded in these landforms, provide the information about sedimentary characteristics, and the evolutionary history of the Gangotri Glacier Region (GGR). The Gangotri is a well studied glacier, however the sedimentological characteristics and evolution of many landforms are yet to be understood. Therefore, present paper aimed to explain the sedimentological characteristics and the evolutionary history of the outwash plain deposits.
The OWP deposits were studied by making a trench near Bhujbas and collecting the samples from it. The granulometric analysis explain that the mean grain size of the OWP sediments varies from 0.258 ϕ to 2.006 ϕ indicate coarse to medium sand. The skewness, varies from 0.138 ϕ to 0.427 ϕ indicate dominance of fine grained sediments. The kurtosis varying from 0.839 ϕ to 1.067 ϕ explain the dominance of finer sediments. The standard deviation varies from 1.210 ϕ to 1.633 ϕ thus indicating poor sorting of the OWP deposits and fluctuation in the energy of the depositional environment. Five sedimentary facies identified are gravel sandy facies, ripple laminated silty sand facies, sandy facies, poorly sorted sandy facies and silty sand facies.
The study describes that the OWP deposits are stratified, consolidated to semi-consolidated, coarse to fine grained silt, sand and gravels with primary sedimentary structures, which are evolved by glacio-fluvial environment under fluctuating energy conditions during the late Holocene period.
Feasibility assessment of manufacturing carbonized blocks from rice husk charcoal
Authors: Hwang Young-Min , Roh Jae-Seung , Nam Gibeop 
Published: September 2023

AbstractArtificial graphite has recently attracted significant interest as a promising carbon material for industrial applications because of its high heat and chemical resistance, excellent electrical conductivity, and low thermal expansion. However, its practical use is severely limited by its high preparation costs and poor cycling stability. In this study, rice husk charcoal (RHC) was prepared from agricultural biowaste using a pyrolysis (heat treatments) method in this study. We investigated the effect of the heat-treatment temperature on rice husk via elemental and thermogravimetric analyses. The results indicated that the rice husk heat treated at 400 °C (RHC 400) was thermally stable with a high carbon content. Its preparation process was also relatively inexpensive. Further, carbonized blocks were prepared using the fabricated RHC and compared their properties with those of artificial graphite scrap (AGS) carbonized blocks. The bulk density, porosity, flexural strength, and electrical resistivity of the RHC carbonized block were 1.14 g/cm3, 24.65%, 52.55 MPa, and 142.93 μΩm, respectively. These results demonstrate that the flexural strength and electrical resistivity of the RHC-prepared block were higher than those of the AGS carbonized block. In contrast, its density was lower than that of the AGS carbonized block.
Consideration of the influences of the driving direction within the calculation of the pitting load-carrying capacity of bevel and hypoid gears
Authors: Constien Lorenz , Drechsel Alexander , Pellkofer Josef , Reimann Tobias , Stahl Karsten 
Published: September 2023

AbstractPitting is, besides scuffing, tooth flank fracture and the phenomenon micropitting, one of the primary failure modes of the flank load-carrying capacity of bevel and hypoid gears. The international standard ISO 10300-2:2014 is widely used for the estimation of the flank load-carrying capacity of bevel and hypoid gears based on operational data and the macrogeometry of the gear set. The calculated safety factors against pitting often show similar values for pinion and wheel. Due to similar safety factors against pitting, the gear is expected to fail as often as the pinion. However, investigations in the field do not confirm this. Initial experimental investigations show an influence of the driven and driving part of the gear set. Within this paper, the phenomenon regarding the driven and driving part of the gear set will be discussed for the first time and the influence parameter will be clarified. Because of the potential for recuperation in electrified agricultural tractors, railroad trains, hybrid and electrical vehicles, this topic is of great importance. In this context an actual calculation approach based on the standard calculation method of the ISO 10300-2:2014 will be presented and verified with test results.
Aspetti neuropsicologici dell’eccesso di GH
Authors: Sala Elisa , Mantovani Giovanna 
Published: September 2023

SommarioL’acromegalia è una malattia sistemica con segni e sintomi caratteristici, tra cui alterazioni delle caratteristiche facciali e ingrossamento delle estremità acrali. Sebbene le alterazioni neuropsicologiche non siano storicamente associate a questa malattia, la pratica clinica ha dimostrato che sintomi psicologici possono essere presenti nei pazienti acromegalici e avere un impatto significativo sulla qualità della vita. La qualità della vita nel paziente con acromegalia è un parametro importante per definire il compenso di malattia globale ed è direttamente influenzata, oltre che dalle terapie e dalla sintomatologia clinica, anche dal quadro neuropsicologico. Ad oggi, diversi studi hanno individuato una maggiore incidenza di patologia neuropsicologica nei pazienti affetti da acromegalia; in particolare, i pazienti hanno tassi più elevati di disturbi affettivi come depressione, ansia e disturbi somatici. Inoltre, come intuibile, anche le modificazioni dell’aspetto corporeo contribuiscono a innescare disturbi di percezione del proprio corpo che, oltre ad essere debilitanti di per sé, contribuiscono al mantenimento e all’aggravarsi della patologia psicologica in generale. Inoltre, valutazioni più complete e specialistiche dal punto di vista neurocognitivo hanno dimostrato come i pazienti acromegalici soffrano anche di una diminuzione della performance cognitiva in diversi domini, peggiorando ulteriormente il quadro globale e la qualità di vita. È interessante segnalare come tutte queste problematiche dipendenti dall’effetto di GH sul sistema nervoso centrale creino delle alterazioni a lungo termine, che non regrediscono con il raggiungimento del controllo o della cura di malattia. Per questo motivo, oltre ad auspicare ulteriori studi più approfonditi per meglio comprendere l’impatto di GH e IGF1 sul quadro neuropsicologico, raccomandiamo nella pratica clinica maggiore attenzione a questo aspetto, con un approccio sempre più multidisciplinare, comprendente anche la collaborazione di neuropsicologi, psichiatri e neurologi nel team dedicato al paziente acromegalico.