bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood donation in China from 2017 to 2021: A cross-sectional study
Authors: Wang Jing , Pan Xinyao , Zhou Jing , Wang Ling 
Published: September 2023

Objective: The objective of this cross-sectional study is to examine the essential demographic characteristics of blood donors in China from 2017 to 2021 and to analyze the impact of various factors on blood donation in China, including the blood donor’s attitudes towards family replacement/mutual blood donation (FRMBD) and the effects of policy changes on blood donation. Design: This study is a cross-sectional review comparing the demographic characteristics of blood donors from 2017 to 2021. Setting and participants: The study included 1164 participants who were randomly sampled across China. The data were collected by trained staff and entered into a standard electronic data framework. Results: The number of blood donations observed in China generally increased from 2017 to 2021. Among the 1164 respondents, 785 were non-blood donors and 379 were blood donors. Most people’s awareness of blood donation comes from organizations. Univariate analysis showed significant relationships between being a blood donor and being aged 30 or above ([Formula: see text], [Formula: see text]), being a doctor ([Formula: see text], [Formula: see text]), having Ph.D. degrees ([Formula: see text], [Formula: see text]), or being familiar with blood donation policy ([Formula: see text], [Formula: see text]). There was no significant difference in recognition between family FRMBD and voluntary non-remunerated blood donation (VNRBD). The study also investigated the impact of canceling FRMBD blood donation policies on the selection of blood donation methods. The results showed that the percentage of VNRBD was 57% and 41% in 2017 and 2021, respectively. This indicates that canceling FRMBD policies will not affect people’s choice for blood donation methods. Conclusions: The results of the univariate analysis showed that people over 30 years of age, those with a Ph.D. or postgraduate degree, and those with knowledge of blood donation policies were more likely to be blood donors. People’s reasons for banning the abolition of FRMBD may be due to the fact that it may not be possible to achieve an adequate supply of blood only through VNRBD. Through comparing the data of 2017 and 2021, it is found that the cancellation of the FRMBD blood donation policy will not have an impact on people’s blood donation ways, and most people agree to cancel the FRMBD. Strengths and limitations of this study Strengths: This study analyzed factors related to decisions about blood donation in various regions of China. For the first time, we analyzed changes in perceptions of blood donation and donation rates before and after the abolition of FRMBD. • This survey did not record changes in the dynamics of the number of blood donations counted over consecutive years. • The individual donor factors such as gender and regional differences in blood donation awareness and facilities, which contribute to regional differences in people’s blood donation behavior, were not investigated.
Genetic Variants That Impact Alternative Polyadenylation in Cancer Represent Candidate Causal Risk Loci
Authors: Li Bin , Cai Yimin , Chen Can , Li Gaoyuan , Zhang Ming , Lu Zequn , Zhang Fuwei , Huang Jinyu , Fan Linyun , Ning Caibo , Li Yanmin , Wang Wenzhuo , Geng Hui , Liu Yizhuo , Chen Shuoni , Li Hanting , Yang Shuhui , Zhang Heng , Tian Wen , Zhu Zhongchao , Xu Bin , Li Heng , Li Haijie , Jin Meng , Wang Xiaoyang , Zhang Shaokai , Liu Jiuyang , Huang Chaoqun , Yang Xiaojun , Wei Yongchang , Zhu Ying , Tian Jianbo , Miao Xiaoping 
Published: September 2023

Abstract

Alternative polyadenylation (APA) is emerging as a major mechanism of posttranscriptional regulation. APA can impact the development and progression of cancer, suggesting that the genetic determinants of APA might play an important role in regulating cancer risk. Here, we depicted a pan-cancer atlas of human APA quantitative trait loci (apaQTL), containing approximately 0.7 million apaQTLs across 32 cancer types. Systematic multiomics analyses indicated that cancer apaQTLs could contribute to APA regulation by altering poly(A) motifs, RNA-binding proteins (RBP), and chromatin regulatory elements and were preferentially enriched in genome-wide association studies (GWAS)–identified cancer susceptibility loci. Moreover, apaQTL-related genes (aGene) were broadly related to cancer signaling pathways, high mutational burden, immune infiltration, and drug response, implicating their potential as therapeutic targets. Furthermore, apaQTLs were mapped in Chinese colorectal cancer tumor tissues and then screened for functional apaQTLs associated with colorectal cancer risk in 17,789 cases and 19,951 controls using GWAS-ChIP data, with independent validation in a large-scale population consisting of 6,024 cases and 10,022 controls. A multi-ancestry–associated apaQTL variant rs1020670 with a C&gt;G change in DNM1L was identified, and the G allele contributed to an increased risk of colorectal cancer. Mechanistically, the risk variant promoted aberrant APA and facilitated higher usage of DNM1L proximal poly(A) sites mediated by the RBP CSTF2T, which led to higher expression of DNM1L with a short 3′UTR. This stabilized DNM1L to upregulate its expression, provoking colorectal cancer cell proliferation. Collectively, these findings generate a resource for understanding APA regulation and the genetic basis of human cancers, providing insights into cancer etiology.

Significance:
Cancer risk is mediated by alternative polyadenylation quantitative trait loci, including the rs1020670-G variant that promotes alternative polyadenylation of DNM1L and increases colorectal cancer risk.
A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody–Drug Conjugate for Targeting Melanoma
Authors: Shi Jing , Jiao Tao , Guo Qian , Weng Weining , Ma Linjie , Zhang Qing , Wang Lijun , Zhang Jianjian , Chen Caiwei , Huang Yaling , Wang Mingqiao , Pan Rong , Tang Yanfang , Hu Wenhao , Meng Tao , Liu Shu-Hui , Guo Jun , Kong Yan , Meng Xun 
Published: September 2023

Abstract

Recent advances in targeted therapy and immunotherapy have substantially improved the treatment of melanoma. However, therapeutic strategies are still needed for unresponsive or treatment-relapsed patients with melanoma. To discover antibody–drug conjugate (ADC)–tractable cell surface targets for melanoma, we developed an atlas of melanoma cell surface–binding antibodies (pAb) using a proteome-scale antibody array platform. Target identification of pAbs led to development of melanoma cell killing ADCs against LGR6, TRPM1, ASAP1, and MUC18, among others. MUC18 was overexpressed in both tumor cells and tumor-infiltrating blood vessels across major melanoma subtypes, making it a potential dual-compartment and universal melanoma therapeutic target. AMT-253, an MUC18-directed ADC based on topoisomerase I inhibitor exatecan and a self-immolative T moiety, had a higher therapeutic index compared with its microtubule inhibitor–based counterpart and favorable pharmacokinetics and tolerability in monkeys. AMT-253 exhibited MUC18-specific cytotoxicity through DNA damage and apoptosis and a strong bystander killing effect, leading to potent antitumor activities against melanoma cell line and patient-derived xenograft models. Tumor vasculature targeting by a mouse MUC18-specific antibody–T1000-exatecan conjugate inhibited tumor growth in human melanoma xenografts. Combination therapy of AMT-253 with an antiangiogenic agent generated higher efficacy than single agent in a mucosal melanoma model. Beyond melanoma, AMT-253 was also efficacious in a wide range of MUC18-expressing solid tumors. Efficient target/antibody discovery in combination with the T moiety–exatecan linker–payload exemplified here may facilitate discovery of new ADC to improve cancer treatment.

Significance:
Discovery of melanoma-targeting antibodies using a proteome-scale array and use of a cutting-edge linker–payload system led to development of a MUC18-targeting antibody–exatecan conjugate with clinical potential for treating major melanoma subtypes.
The Unexpected Benefit of TCR Cross-Reactivity in Cancer Immunotherapy
Authors: Bieberich Florian , Reddy Sai T. 
Published: September 2023

Abstract
The ability of T-cell receptors (TCR) to recognize tumor-associated antigens (TAA) is a key driver of adoptive transfer of tumor-infiltrating lymphocyte (TIL) T cells, which can be a highly effective cancer immunotherapy. While it is common knowledge that TCRs are cross-reactive and can bind multiple different peptide antigens, this is typically considered an unattractive feature and limitation for TCR-based therapies. In a recent publication in Cell, Dolton and colleagues discover that certain TCRs, isolated from TILs used for successful treatment of melanoma, possess beneficial cross-reactivity by recognizing multiple TAA. Moreover, they elucidate the cumulative value of TCR cross-reactivity on cancer cell eradication and its prospective advantages for targeted cancer immunotherapies.
C-X-C Motif Chemokine Ligand 9 Correlates with Favorable Prognosis in Triple-Negative Breast Cancer by Promoting Immune Cell Infiltration
Authors: Cao Xi , Song Yu , Wu Huanwen , Ren Xinyu , Sun Qiang , Liang Zhiyong 
Published: September 2023

Abstract
C-X-C motif chemokine ligand 9 (CXCL9) plays an important role in antitumor immunity through the recruitment, proliferation, and activation of immune cells (IC).
Here, we evaluated the expression patterns of CXCL9 and programmed death-ligand 1 (PD-L1) in a cohort of 268 patients with triple-negative breast cancer (TNBC) by tissue microarray (TMA). The correlations between CXCL9 expression in ICs or tumor cells (TC) and clinicopathologic parameters, PD-L1 expression, tumor-infiltrating lymphocytes (TIL) and survival were analyzed in this cohort (n = 268). In addition, we analyzed a TNBC dataset (n = 138) from The Cancer Genome Atlas (TCGA) to identify correlation between CXCL9 expression and other immune gene expression, immune infiltration, and prognosis. The results of the TMA cohort (n = 268) showed that CXCL9 was expressed in 80.6% cases, with elevated expression levels in ICs relative to in TCs (median: 1% vs. 0%). CXCL9 expressed in ≥1% of ICs was categorized as the CXCL9-IC–positive group. CXCL9-IC expression was strongly and positively correlated with the PD-L1 expression, CD3+ TILs, CD4+ TILs, CD8+ TILs, and CD19+ TILs (all P &lt; 0.0001). Survival analyses showed that the CXCL9-IC–positive group demonstrated prolonged disease-free survival (P = 0.038) and overall survival (P = 0.023) compared with the negative group. The analyses from TCGA cohort (n = 138) showed that elevated CXCL9 expression correlated with increased infiltration of B cells, macrophages, natural killer cells, monocytes and increased expression of immune checkpoint molecules and other CXCL family members, including CXCL10 and CXCL11. These findings confirm the regulatory role of CXCL9 in antitumor immunity and suggest a potential role in treatments involving immune checkpoint blockade.
Three new species of the Neotropical genus Hapigia Guenée from Brazil (Lepidoptera, Notodontidae, Heterocampinae)
Authors: Becker Vitor Osmar 
Published: September 2023

Three new species of Hapigia Guenée, 1854, from Brazil and Ecuador, are described: H. postpallida Becker sp. nov., H. violacea Becker, sp. nov. and H. violetta Becker, sp. nov.
A new species of Dilophochila Bates, 1888 with comments on natural history and distribution of the genus (Coleoptera: Melolonthidae: Rutelinae)
Authors: Ramírez-Ponce Andrés , Zaragoza-Caballero Santiago , Curoe Daniel J. 
Published: September 2023

A new species, Dilophochila glabra sp. nov. is described from the Sierra Norte, Oaxaca, Mexico. Diagnosis and images (dorsal, lateral and ventral habitus, and genitalia) of the taxonomic characters are provided. Affinities with their closest congeners and the general distribution pattern of the genus are discussed, considering that it presents a typical Mountain Paleoamerican sub-pattern. The modifications in the mouthparts of this genus due to the specialization in the intake of pine needles are commented, as well as in two other different taxa within Anomalini.
Barriers to Equity Within Environmental Justice and Climate Justice Grant Programs
Authors: Buchanan Mary , Wozniak-Brown Joanna 
Published: September 2023

Abstract
In 2020, Connecticut undertook a statewide engagement process via the Governor’s Council on Climate Change (GC3) to develop priorities for climate change mitigation and adaptation, especially from an equity approach. A priority action from the GC3 process called for grants to fund participation by community-based organizations and nongovernmental organizations to increase representation from communities that have been marginalized. This is similar to efforts from other states and the federal government to direct funds to historically excluded groups to redress inequities or to financially support their participation and sharing of their expertise in these processes. While the programs have the intent to address inequity, often the grantmaking mechanisms can make it harder for marginalized groups to participate in the grant process, nullifying the grant’s intent. This review of environmental justice and climate justice grant programs offers insight to grantmakers on embedding equity into the grant process and, ideally, achieving their intent.
Pandemic Response and Mutual Aid as Climate Resilience: Learning From
Community Responses in the Boston Area
Authors: Loh Penn , Estrella-Luna Neenah , Shor Katherine 
Published: September 2023

Abstract
Community responses to the impacts of COVID-19 in working-class communities of color in the Boston area are examples of resilience in action. Building climate resilience is not just about hardening physical infrastructure but also about strengthening social and civic infrastructure to reach and protect the most vulnerable. This article explores the lessons learned from the pandemic for more equitable approaches to climate resilience. We find that community-based organizations and networks are building social capital through mutual aid networks rooted in solidarity, care, and reciprocity and forging new collaborations with government, funders, and service providers. These social capacities have saved lives and can also help transform the systems that produce vulnerabilities and inequities in the first place. Our overarching conclusion is that resilience is rooted in our abilities to work together, mobilize resources, and take care of one another.
Cultural Conceptualization of Congratulatory Happy Events in British English and Turkish: A Cross-Cultural Perspective
Authors: Can Hümeyra , Hatipoğlu Çiler 
Published: September 2023

Abstract
This study investigates the cultural conceptualization of congratulatory happy events in British English and Turkish and discusses them cross-culturally. A lexical search was carried out in various corpora from the newspaper genre using the verbs congratulate in English and its dictionary counterparts tebrik etmek and kutlamak in Turkish along with their various lexical forms, which not only report the act of congratulating but also perform it. The results of the study showed that there were cultural differences and similarities in the conceptualization of congratulatory happy events. It was found that there were subtle differences between the events of tebrik etmek and kutlamak in the Turkish data and that the Turkish tebrik etmek was closer to congratulating although congratulating events were relatively more restricted. This study contributes to the socio-cultural dimension of congratulating and provides a cross-cultural understanding of congratulatory happy events with implications for foreign language education and intercultural communication.
The Effects of Foreign Language and Religiosity on Moral Decisions: Manipulating Norms and Consequences
Authors: Barabadi Elyas , Tabar Mohsen Rahmani , Booth James R. 
Published: September 2023

Abstract
The primary purpose of this study was to examine the association of foreign language use and religiosity to moral decision-making in the context of a realistic set of scenarios about the COVID-19 pandemic. We used the CNI model in which four variants of a single dilemma manipulated norms and consequences, which are the defining characteristics of deontology and utilitarianism, respectively. A secondary purpose of the study was to investigate the role of in-group versus out-group membership in shaping moral judgment. 461 participants responded to COVID-19 scenarios either in their native language (Persian) or foreign language (English). Contrary to findings of prior research on moral judgment, the results of the current study indicated that those using their native language showed more sensitivity to consequences compared to those using a foreign language and that less religious individuals were more likely to endorse norms compared to more religious participants. These unexpected findings may be attributed either to the use of more realistic scenarios or to some problems associated with the use of the CNI model. Further, participants’ responses did not significantly differ as a result of group membership, but in line with prior research, exploratory analyses revealed that men showed greater sensitivity to consequences.
Pseudotaeniacanthus japonicus sp. nov. (Copepoda, Cyclopoida, Taeniacanthidae) recovered from Conger japonicus Bleeker, 1879 (Actinopterygii, Anguilliformes) in Japan, with description of copepodids V-III of the species
Authors: Izawa Kunihiko 
Published: September 2023

Abstract
Pseudotaeniacanthus japonicus sp. nov. (Taeniacanthidae) is described based on specimens of both sexes recovered from the body surface and the bucco-branchial cavity of the beach conger, Conger japonicus Bleeker, 1879 (Congridae) in Japan. C. japonicus represents a new host for the family. Copepodids V-III of the species are also described.
“Capture with a camera!” A non-contact method for obtaining the body size data from ovigerous female land crabs during breeding migration
Authors: Hsu Chia-Hsuan , Hatch Kent A. , Hwang Wenbe , Chang Chung-Chieh , Liu Chia-Chun , Huang Wei-You , Kao Chung-Jui , Hu Yung-Jen , Cheng Chia-Hsin , Chang Yuan-Mou 
Published: September 2023

Abstract
Body size is a crucial metric that is often obtained during the breeding migration of female land crabs. Most commonly, these measurements are obtained by hand but hand-measuring them carries risks for both crabs and researchers. In this study, we developed a novel “photo-image approach” to measure the maximum carapace width of Cardisoma carnifex (Herbst, 1796) in the field, and compared the results with hand measurements. We found a significant relationship in the maximum carapace width measured between the two approaches (Linear regression, , ). The difference (0.54 ± 0.18 mm) and relative error (0.61 ± 0.19%) in the maximum carapace width measured between the two approaches were minimal. We suggest that the photo-image approach is feasible for determining crab size in the field. The approach holds promise for its application in citizen science projects, facilitating advancements in crab research.
Activities and Counterstrategies; Populism during the COVID-19 Pandemic
Authors: Olivares-Jirsell Jellen , Hellström Anders 
Published: September 2023

Abstract
The COVID-19 pandemic has created an impetus for action for governments and citizens, but these actions can be challenging to understand. As a riposte, we use The Populist Divide as a framework for understanding the patchwork of populist responses to the COVID-19 pandemic. Our approach brings nuance to how crises are framed dependent on the trust levels between actors, thus presenting populist relationships as determined by selective trust allocation and not necessarily one of fixed ideological paradigms. Additionally, we introduce activities as the response to a measure, whether accepting or even protesting, but ultimately consenting to the legitimate powers of the leaders imposing these measures. On the other hand, counterstrategies emerging as challenges to the legitimacy of the leaders themselves.
Species delimitation in the Chlorophytum andongense complex
Authors: SÆVAREID MALIN , CARLSEN TOR , CHAPANO CHRISTOPHER , BJORÅ CHARLOTTE SLETTEN 
Published: September 2023

Molecular, morphological and chromosome research have identified several subgroups in Chlorophytum. One of the subgroups has been referred to as “The paniculate spongy-rooted group”, where the delimitation of several species have been questioned. To determine if this is a natural group and to clarify taxonomic boundaries between species, molecular phylogenetic analyses were performed based on ITS, rps16 intron, trnL intron, trnL‑F spacer, psbA-trnH spacer, and rps12-rpl20 spacer. Chlorophytum hirsutum, hypothesized to be sister to C. andongense, did not resolve within “The paniculate spongy-rooted group”. A closer examination of the roots of C. hirsutum showed they were different from roots of the other members of this group. Two species, C. andongense and C. macrosporum, have been suggested to be conspecific, however, this study found that the taxa were genetically and morphologically distinct. The analyses further revealed considerable genetic variation in the geographically widespread species C. andongense, something that should be studied further.
The CELTIC ranges project (comprehensive and effective laboratory test reference intervals for Irish children) methodology and results for renal profile tests in plasma on the Roche modularTM system
Authors: Leonard Ann , Bolger Turlough , Molloy Eleanor , Boran Gerard 
Published: September 2023

Background The CELTIC ranges project aims to deliver a comprehensive range of reference intervals for commonly ordered laboratory investigations suitable for use in an Irish population as well as enabling comparison with relevant international studies. In this paper, we describe our methodology used throughout the entire project and present paediatric reference intervals for renal profile tests in plasma (sodium, potassium, urea and creatinine). Methods 1023 children aged up to 17 years were recruited from our hospital’s general practitioner paediatric phlebotomy clinic. Clinical chemistry analyses were performed on the Roche modular system and statistical analysis was completed in line with CLSI guideline EP28-A3c. Results The plasma reference interval for sodium for ages 0.45–16.99 years was 137–143 mmol/L in 1000 subjects (combined genders). For plasma potassium, the corresponding ranges between 1 and 16.99 years (combined genders) were 3.6–4.8 mmol/L. Apart from neonates and in keeping with other studies, age partitioning for electrolytes was not required. Data for plasma creatinine (enzymatic methodology) and urea is also presented and, as anticipated, required partitioning for both age and gender. Conclusions Our renal profile findings are broadly consistent with those of international studies, for example, CALIPER, HAPPI, NORDIC, PRINCE and KiGGs. Moreover, the CELTIC ranges study is also based on over 1000 subjects whose samples were analysed on the widely used Roche modular analytics system. We also expect the findings will improve knowledge of children’s metabolic health in Ireland.