bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal Trends in Hippocampal Sclerosis Surgery: An Observational Study From a Tertiary Epilepsy Centre
Authors: Vassallo Paola , Gursal Vaishali , Xiong Weixi , Zhou Dong , de Tisi Jane , Thijs Roland D. , Duncan John S. , Sander Josemir W. 
Published: January 2025

ABSTRACTObjectiveTemporal lobe epilepsy with hippocampal sclerosis (HS) is a surgically remediable syndrome. We determined temporal trends in the prevalence of hippocampal sclerosis surgeries and related factors.MethodsWe analysed a prospective cohort of adults who underwent epilepsy surgery at the NHNN, London, between 1990 and 2019. HS group was compared with other pathologies. Demographics, surgical trends for HS and associations with sex, age, prior neurological insults and febrile seizures were analysed. Temporal trends were assessed by one‐way or Welch ANOVA, with post hoc analysis. Surgery latency over three decades was evaluated with the Kruskal–Wallis H test, using Dunn's procedure for pairwise comparisons. Chi‐squared analyses examined associations with sex, age at operation, febrile seizures, and between resection side and handedness.ResultsOf 1069 people operated, 586 had hippocampal sclerosis. After increasing, surgeries declined in the last decade (from 322 to 131), as did the number of people with hippocampal sclerosis and a history of childhood febrile seizures (from 87 to 23). The median interval from epilepsy onset to surgery increased from 22 to 24 and 27 years over each decade. Female sex and febrile seizures were associated with pathology (HS vs. non‐HS) but not age at surgery, previous neurological insults, or the resection side and handedness.DiscussionOur study confirms the decline in hippocampal surgeries. This trend may be due to changes in the syndrome's natural history, possibly from improved paediatric care, and an increase in complex cases. The impact of delayed referrals, surgical risk fears and newer anti‐seizure medications remains unclear.
Sangharsh: (nm) Struggle; Conflict, Friction: Creative Workarounds in Negotiating Friction Arising from Patriarchy!
Authors: GANESH VIDYA 
Published: January 2025

India is a country of people belonging to varied socioeconomic backgrounds. Patriarchy is very much evident in the day to day lives of the different people we speak to in the course of our work.As an ethnographer I am always interested in and amazed by the creativity of these rural women, their never give up attitude to maintain their identity, the bond they form with their community to continue growing and as a mother of two urban girls am fascinated by the diversity in situations yet similarity of the workarounds in place for both these completely different worlds. I am always struck by the difference in the approaches to life situations but also the commonality of finding a workaround to achieve what they want and slowly expand their boundaries. I can't help but wonder what the future is going to bring to all of these life journeys. In my PechaKucha I am sharing how these women navigate and negotiate the various frictions that arise either from the patriarchy within their homes or from society. How do they get around gatekeepers and what can be done to make their lives more frictionless?
Eumelanic Coloration Impacts Mating Behavior, Stress Response, and Predator Preference in the Polymorphic Eastern Mosquitofish
Authors: Humphrey Eve , Wright Christine , Martinez Christian , Jones Blake , Hughes Kimberly , Travis Joseph 
Published: January 2025

ABSTRACTThe expression of melanic or black coloration is ubiquitous and has significant behavioral and ecological relevance. Although black coloration is common, melanic morphs within populations are often considered rare. The mechanism for the maintenance of rare melanic morphs is often associated with differences in morph behavior, predator preference, or the interaction of both. Mechanistically, the genetic loci associated with black coloration in rare morphs can also influence behaviors, and these pleiotropic effects may provide some benefit to black morphs. We predicted that different mating behaviors, antipredator responses, and stress response, as well as predator preference influenced the maintenance of a rare black morph in freshwater Eastern mosquitofish. We created predator and control treatments to measure differences in melanic and silver mosquitofish behavior and cortisol levels. We also measured predator approach and attack of melanic and silver morphs. Overall, melanic morphs exhibited a higher number of mating behaviors compared to silver morphs and returned to mating attempts quicker than silver morphs after predator exposure. Melanic males also exhibited higher baseline cortisol levels, but silver males produced more cortisol after predator exposures compared to melanic males. These specific responses may provide the mechanism by which melanic males continue to persist in populations where they are rare.
Does the Fishery or Climate Change Drive Commercial Catches in a Shallow Eutrophic Lagoon?
Authors: Ivanauskas Edgaras , Razinkovas‐Baziukas Artūras , Baziukė Dalia 
Published: January 2025

ABSTRACTClimate change has significantly affected the Curonian Lagoon, the largest coastal lagoon in Europe, which is of great economic importance to fisheries and tourism. We modeled how environmental factors and fisheries affected recruitment and subsequent catches of pikeperch (Sander lucioperca L.) and common bream (Abramis brama L.) in the lagoon. Recruitment, catch per unit effort (CPUE), environmental variables, and fishery catch, and effort were used to construct Bayesian belief networks (BBNs) for both fish species. Catches of pikeperch and common bream depended more on fishing effort than recruitment. Environmental factors (temperature and riverine discharge) were only weakly related to catches of pikeperch and common bream. Changes in salinity and temperature are expected to have only minor direct effects on populations of pikeperch and common bream.
Low trunk muscle mass could predict severe stress urinary incontinence in Asian women
Authors: Cheng Weiming , Chen Sheng‐Wen , Chiu Yi‐Chun , Fan Yu‐Hua 
Published: January 2025

AimAdequate pelvic floor support for the urethra is crucial for preventing stress urinary incontinence (SUI). Obesity is an established risk factor for SUI. This study aimed to explore the relationship between SUI and body composition, specifically focusing on muscle and fat mass.MethodsThis single‐center, prospective, cross‐sectional study enrolled women who visited the genitourinary clinic of Taipei City Hospital‐Zhongxiao Branch between 1 February 2020 and 31 January 2021. SUI severity was classified according to the type of daily activity in which SUI occurred. Potential risk factors for SUI, including age, labor and history of hysterectomy, were also included. All participants underwent a bioelectric impedance analysis of their body composition. Independent t‐tests and Pearson's χ2‐tests were used to compare the differences in continuous and categorical parameters between groups. Logistic regression analysis was used to characterize the predictive value of body composition for severe SUI.ResultsOf the 256 included patients, 37 had severe SUI. The participants with severe SUI were older and were more likely to have undergone a hysterectomy. They also had a considerably higher prevalence of sarcopenia. In the univariate analysis, a sarcopenia diagnosis was associated with severe SUI. Furthermore, a history of hysterectomy correlated with severe SUI, although with borderline significance. In the multivariate analysis, a history of hysterectomy and lower trunk muscle mass index were found to be independent predictors of severe SUI.ConclusionsA history of hysterectomy and a lower trunk muscle mass index are correlated with severe SUI. Geriatr Gerontol Int 2025; 25: 226–231.
When Do Liberal Governments Restrict Civil Society?
Authors: Bolleyer Nicole , Eick Adam , Ivanovska Hadjievska Milka , Grevesmühl Leonhard 
Published: January 2025

ABSTRACTLiberal democracies increasingly restrict civil society organizations (CSOs), a trend frequently linked to illiberal governments. But when do ideologically liberal governments resort to such restrictions? Linking research on state traditions, party ideology and crisis governance, we theorize factors enhancing liberal governments' propensity to adopt normatively contentious CSO restrictions. Distinguishing formal‐legal restrictions on CSO voice from those on CSO existence, we show that nearly 90 such restrictions were adopted by 17 cabinets in France and the United Kingdom over the last 2 decades. In line with theoretical expectations, restrictions on CSO existence are more prominent in statist France, while governments in the United Kingdom tend to restrict CSO voice. More right‐wing governments adopt more CSO restrictions, while restrictions go up with government crisis pressure. Overall, understanding how liberal governments use CSO restrictions requires considering contextual opportunity structures and ideological dispositions in conjunction.
Poverty exposure and poverty persistence for large families in Western Europe. A dynamic perspective
Authors: Cutuli Giorgio 
Published: January 2025

AbstractThis paper investigates income poverty in 14 Western European countries from 2004 to 2019, utilizing European statistics on income, social inclusion and living conditions longitudinal data. The study employs descriptive tables and panel regression models to examine poverty exposure and accumulation of poverty events over time for families with dependent children with a focus on large families with three and four or more children. The findings reveal that in all countries the reiteration of poverty spells, net of persistence dynamics, primarily results from higher risks for large families of falling back into poverty. The analysis shows large families experience carousels of poverty reoccurrence, especially among single‐earner households. All in all, analyses suggest the necessity for integrated social policies for large families, combining timely social transfers to mitigate current spells of poverty, with mid‐term follow‐up programs in the form of preventive measures tailored to families with recent poverty experiences.
Expanding access to maggot containment dressings through redesign and innovation
Authors: Sherman Ronald Arlen , Stadler Frank 
Published: January 2025

AbstractThere are two major styles of maggot debridement dressings: (1) confinement dressings that form a cage around the wound, and (2) containment dressings that completely surround the maggots within a sealed porous bag. For producers and clinicians wanting to prepare containment dressings using readily available polyester bags, it is currently difficult to seal these bags without expensive high‐temperature plastic welders. This study aimed to identify simple and affordable methods for sealing maggots within polyester net bags. Heat sealing was the most effective and simplest method to seal the polyester net bags, but the high melting point of polyester required industrial grade heat sealers. An inner lining of polyethylene or polypropylene film at the open side of the bag allowed for complete sealing using low‐cost hand‐actuated impulse heat sealers. This design even facilitated the addition of plastic zipper‐locks, allowing secure closure of the bag without electricity or special equipment. Other sealing methods were identified, but most were time‐consuming, required practice or not consistently successful. The maggot containment bag designs and closure methods described herein should prove useful to clinicians without access to contained maggots and to maggot producers without the resources to seal polyester containment bags. Clinical trials are expected to follow.
Digital Infographic Creation in Design Education: A Participatory Learning Algorithm Measuring Location‐Based Spatial Impact
Authors: Birer Emel , Hasgül Esin , Metin Elif Gizem 
Published: January 2025

AbstractDesign education includes many pursuits that deal with creativity, thinking and visual communication techniques in the learning process. This study aims to create a participatory learning algorithm based on a location, while measuring the spatial impact through an emergent situation. The exemplified issue is determined as fire that emerged due to climate change, which has become a significant agenda of the 21st century in most countries. The scope of the study is based on the creation of an algorithm for participatory learning techniques by using social media to create digital infographics in a workshop redefining Mugla, an affected place after the fire. The workshop context is designed to reveal the interaction between humankind and its natural environment, including nature, topography, animals, aids and all actors affected after the fire, while students are involved in research practices on participatory learning, using the diary method as a pedagogical research tool. The outputs of the participatory learning algorithm examine the informative part of the produced digital infographics with ethnomethodology and the visual part with descriptive analysis as a hybrid methodology taking data materials from social media. Cumulative results that reflect the location‐based spatial impact are measured with a coding system of frequencies and a time‐series data of polar mapping. We propose that such a participatory learning algorithm can improve students' visual communication, design creation, visualisation, expression of ideas and organisation of knowledge skills with the discipline of working together to make multilayered spatial readings.
Hydrogen‐Rich Saline Combined With Vacuum Sealing Drainage Promotes Wound Healing by Altering Biotin Metabolism
Authors: Kuang Xinwen , Liang Zhengyun , Xia Yijun , Shan Mengjie , Hao Yan , Liu Hao , Wang Zhi , He Qianjun , Xia Chao , Feng Cheng , Chang Guojing , Wang Youbin 
Published: January 2025

ABSTRACTImpaired wound healing affects the life quality of patients and causes a substantial financial burden. Hydrogen‐rich medium is reported to have antioxidant and anti‐inflammatory effects. However, the role of hydrogen‐rich saline (HRS) in cutaneous wound healing remains largely unexplored, especially by metabolomics. Thus, untargeted metabolomics profiling was analysed to study the effects and mechanism of HRS combined with vacuum sealing drainage (VSD) in a rabbit full‐thickness wound model. Our results indicated that the combination treatment of HRS and VSD could accelerate wound healing. In vitro experiments further confirmed its effects on HaCaT keratinocytes. We found that 45 metabolites were significantly changed between the VSD + HRS group and the VSD + saline‐treated group. Pathway enrichment analysis indicated that biotin metabolism was the potential target pathway. The biochemical interpretation analysis demonstrated that combining HRS and VSD might enhance mitochondrial function, ATP synthesis, and GSH homeostasis by altering biotin metabolism. The detection of representative indicators of oxidative stress supported the critical metabolic pathway analysis as well. In summary, VSD combined with HRS might provide a new strategy to enhance wound healing.
USP18 Promotes Cholesterol Efflux and Mitigates Atherosclerosis by Deubiquitinating ABCG1
Authors: An Yang , Guo Chuxian , Wang Xiaoli , Liu Jiangjin , Li Zhu , Ding Jiuyang , Zhang Qiaojun , Zhou Hongmei , Xia Bing , Wang Jiawen , Yu Yanni , Wan Changwu , Wang Jie , Dai Jialin 
Published: January 2025

ABSTRACTDeubiquitinating enzymes (DUBs) are integral regulators of protein stability. Among these, Ubiquitin‐specific protease 18 (USP18) has emerged as a potential therapeutic target for heart failure. However, its precise role in atherosclerosis remains to be comprehensively understood. This study endeavours to examine the impact of USP18 on atherosclerosis and elucidate its corresponding molecular mechanisms. Our studies indicate an elevated expression of USP18 in human coronary atherosclerotic plaques. Notably, the knockdown of USP18 significantly exacerbated lipid accumulation in macrophages. This knockdown effect impaired cholesterol efflux and influenced the downregulation of ATP‐binding cassette transporter G1 (ABCG1) expression, achieved by altering the ubiquitination level of ABCG1. Comprehensive mechanistic studies unveiled that USP18 directly affiliates with ABCG1, reducing its ubiquitination and consequently bolstering ABCG1 stability within macrophages. Furthermore, in vivo studies elucidated that the knockdown of USP18 notably elevated atherosclerotic lesions and diminished ABCG1 levels in the plaques of Apoe−/− mice. In summary, our results suggested that USP18 plays a crucial role in managing the progression of atherosclerosis by strengthening the expression of ABCG1 protein through its deubiquitinating effect on ABCG1.
Association Between Chewing Capacity and Mortality Risk: The Role of Diet and Ageing
Authors: Du Mi , Deng Ke , Yin Jiawei , Wu Chenkai , Hu Shixian , Guo Linxu , Luo Zhixin , Tonetti Maurizio , Tjakkes Geerten‐Has E. , Visser Anita , Ge Shaohua , Li An 
Published: January 2025

ABSTRACTAimMasticatory dysfunction due to tooth loss is a potentially modifiable risk for mortality, but the pathway behind that remains to be investigated. This prospective study aimed to examine the role of diet and ageing in the associations between chewing capacity and long‐term mortality.MethodsData were obtained from participants (aged ≥ 20) in the National Health Nutritional and Health Survey (NHANES 1999–2010, n = 22,900). The mortality follow‐up ended on 31 December 2019. Chewing capacity was determined by the number of functional tooth units (FTUs). Diet information in NHANES was collected using a 24‐h‐recall questionnaire, and diet quality was measured by three index‐based dietary patterns, namely the nutrition index (NI), energy‐adjusted dietary inflammatory index (E‐DII) and healthy eating index‐2015 (HEI‐2015). The biological ageing process was reflected using phenotypic age acceleration (PhenoAgeAccel) and frailty index. Mediation analyses were conducted to assess the role of diet quality in the association between FTUs and ageing, as well as the role of ageing in the association between impaired chewing capacity (ICC) and mortality.ResultsParticipants with more FTUs were found to have a slower biological ageing process. Diet quality scores were estimated to mediate 9.0%–23.0% of the association between chewing capacity and biological ageing. Multivariable Cox proportional hazards regression models found a positive association between ICC and all‐cause mortality (hazard ratio = 1.282 [95% confidence interval: 1.189–1.382]). Also, ICC was significantly associated with a 28.9% higher risk of mortality due to cardiovascular disease (CVD) and a 32.7% higher risk of mortality due to cancer. Mediation analyses indicated that PhenoAgeAccel mediated the effect of ICC on all‐cause, CVD and cancer mortality with proportions of 18.1%, 17.3% and 12.5%, respectively. Similar mediating proportions were observed in the frailty index (range: 11.6%–23.5%).ConclusionsICC was associated with poorer diet quality and accelerated ageing, resulting in higher mortality risk. Therefore, it is plausible that dietary interventions and oral rehabilitation would promote healthy longevity, although further investigations are needed.
Knowledge, Attitude and Practice of Medical Students Towards Insomnia and Traditional Chinese Medicine Treatment
Authors: Wang Liping , Luo Lan , Liu Lan , Shao Haoqing , Li Qiuying , Zhang Ting , Tian Xiaoying , Chen Shuoxuan 
Published: January 2025

ABSTRACTBackgroundTo assess the Knowledge, Attitude, and Practice (KAP) of medical students at Hunan Medicine College towards insomnia and TCM treatment.MethodsThe study included 676 medical students. More than half were female (64.20%), and 33.8% reported experiencing insomnia for over a week. Participants' KAP scores were evaluated on insomnia and TCM treatment using a scale.ResultsThe mean KAP scores for insomnia were 58.93%, 73.75%, and 64.94%, respectively, indicating insufficient knowledge but positive attitudes and moderate practices. TCM treatment scores were 78.18%, suggesting better awareness. Overall, 67.60% of medical students would choose TCM for insomnia treatment. Multivariable analysis revealed associations between choosing TCM and higher knowledge (OR = 1.30), positive attitude (OR = 1.46), better practice (OR = 3.44), and being in a later academic year (OR = 2.397).ConclusionThe study underscores the need for targeted educational interventions to enhance understanding and promote effective practices among medical students, potentially improving their well‐being and addressing insomnia more comprehensively.
Ofatumumab for treating autoimmune nodopathy
Authors: Hu Jianian , Zheng Yongsheng , Sun Chong , Sun Jian , Xi Jianying , Luo Sushan , Qiao Kai , Zhao Chongbo , Lin Jie 
Published: January 2025

AbstractBackground and AimsTo investigate the treatment of ofatumumab in autoimmune nodopathy (AN).MethodsAn open‐label, prospective, observational study was conducted in patients with AN. The regimen was 20 mg ofatumumab subcutaneously on day 0, 7, 14, 28, and subsequently every 4 weeks in a total of 24 weeks. The primary endpoint of the study was the proportion of patients with confirmed clinical improvement.ResultsAll of the eight patients (100%) improved at Week 24. The median time to improvement was 8 (IQR: 7–10) weeks. The four patients previously treated with rituximab and two with irregular injections of ofatumumab (OFA) improved. At Week 24, the adjusted INCAT score, MRC sum score, cI‐RODS, and grip strength in nondominant hand significantly improved from baseline. In nerve conduction studies, all of the six patients with available data (100%) improved. The median sNfL significantly reduced from baseline at Week 8. Anti‐paranodal antibody in seven patients with anti‐NF155 antibodies reduced from baseline at Week 20. In seven of the eight patients, CD19+ B cells were significantly reduced at Week 4. No serious adverse events were reported.InterpretationThe regimen was 20 mg ofatumumab subcutaneously on day 0, 7, 14, 28, and every 4 weeks from Week 4, in a total of 24 weeks. The ofatumumab therapy may provide a more convenient and safer treatment for patients with AN, while serving as an effective alternative for those who did not respond to rituximab.
Minimal invasive biopsies are highly sensitive for amyloid detection in hereditary transthyretin amyloidosis with polyneuropathy
Authors: Leonardi Luca , Adam Clovis , Beaudonnet Guillemette , Beauvais Diane , Cauquil Cécile , Not Adeline , Morassi Olivier , Trassard Olivier , Echaniz‐Laguna Andoni , Adams David , Labeyrie Céline 
Published: January 2025

AbstractObjectiveTo assess the effectiveness of labial minor salivary gland biopsy (LSGB) alone or in combination with punch skin biopsy (SB) for the detection of amyloid deposits in hereditary transthyretin amyloidosis with polyneuropathy (ATTRv‐PN).MethodsIn this single‐center retrospective study, Congo red staining of minimal invasive LSGB (4 mm) and SB (3 mm) was assessed in ATTRv‐PN patients consecutively evaluated between 2012 and 2023.ResultsHistopathological data of 171 ATTRv‐PN, including 49 early‐onset p.Val50Met, 58 late‐onset p.Val50Met, and 64 non‐p.Val50Met, were reviewed. LSGB and SB identified amyloid deposits in 123/171 (72%) and 131/171 (77%) patients respectively (p = 0.2). Combining LSGB and SB increased the amyloid detection rate to 150/171 (88%), especially in late‐onset p.Val50Met (48/58 [83%]) and non‐p.Val50Met patients (55/64 [86%]). LSGB and SB have a similar rate of detection of amyloid depositions in early onset p.Val50Met patients (94%). Also, the LSGB/SB combination identified amyloidosis in 89% (55/62) of early‐stage ATTRv‐PN patients.ConclusionsIn our study, combining LSGB and SB allowed the detection of amyloid deposits in 88% of ATTRv‐PN patients. LSGB/SB analysis may be of major interest to confirm entry in the disease at very early‐stage ATTRv‐PN, with implications in disease‐modifying treatment initiation.