bluuebunny/crossref_metadata_2025_split huggingface dataset:
UNIVERSAL CODING SYSTEM FOR PALEONTOLOGICAL COLLECTIONS AS AN EFFECTIVE BASIS FOR CREATING A UNIFIED ELECTRONIC COLLECTIONS CATALOG AT THE INSTITUTE OF GEOLOGICAL SCIENCES OF THE NAS OF UKRAINE
Authors: Anistratenko O.Yu. , Vernyhorova Yu.V. 
Published: December 2022

A method of universal coding of paleontological collections is proposed. It is aimed to organize a uniform electronic catalog of various geological collections of the Institute of Geological Sciences of the National Academy of Sciences of Ukraine (IGS NAS of Ukraine). The problems of arranging the data of the natural scientific collections in Ukraine and the peculiarities of the arrangement of paleontological collections of IGS NAS of Ukraine were considered. The absence of a unified template for labeling of paleontological collections of IGS NAS of Ukraine has been stated. This encourages us to elaborate of a convenient universal coding system for the systematization of existing and newly created paleontological collections.
The proposed coding of paleontological collections is based on the unified principle of using universal abbreviations in Latin letters.
The coding system consists of a full code, a short code, and a universal label. The full code is intended for coding the collection’s general characteristics and subsequent use in compiling the universal electronic catalog. The short code is needed for marking an individual specimen within any collection. The universal collection label is a necessary component in the design and storage of a collection, as it carries basic information. It also has an additional reference about the collection and contains information that is also used when compiling electronic catalogs of collections.
The developed coding system is universal and maximally effective in ensuring the uniformity of the code of any collections of a certain scientific institution. It enables the researcher to code collections independently, protects against duplication of the existing code, and is a simple and convenient way of transferring information to the electronic catalog of collections.
Our method greatly facilitates the distribution of information during the direct creation (code writing) of the electronic catalog and is the basis of the search system and sorting information into certain categories. This, in turn, makes it possible to have a multidisciplinary electronic catalog, by which one can find information about existing collections of a certain region, stratigraphic age, a certain paleontological group, or certain geological objects (such as samples from boreholes or outcrops).
The adoption of the unified Catalogue strategy will ensure the reliable functioning of the paleontological collections of the IGS NAS of Ukraine, as well as become the basis for documenting new collections in accordance with established methodology.
Finally, registering all collections is a small but important step in the direction of Open Science, namely, providing open access to information for the scientific community.
Gesundheit und Dichtung – Der arme Heinrich Hartmanns von Aue
Authors: Bulang Tobias 
Published: December 2022

Abstract
This essay explores different concepts of health during the Middle Ages. For clergy and monasticism, the idea of an ascetic life shapes the concepts of body and soul. The nobility defines health with regard to power, genealogy and representation. The pater familias cares for health and prosperity of the family, as well as of the working people and the animals of his household. All these concepts include also ideas of sexuality and reproduction. Different ideas of health get mixed up and interfere in Hartmann’s von Aue tale Der arme Heinrich. Thus, also the sexual implications of the discourses get confronted, what results in a unique poetic eroticism.
Fortinbras
Authors: Höfele Andreas 
Published: December 2022

Abstract
Shakespeare’s Fortinbras has just two brief appearances and fewer than thirty lines to speak. But notwithstanding his physical absence during most of the play, he exerts considerable sway, representing the political world beyond Elsinore and the antithesis to Hamlet. As such he plays a major role in the political afterlife of the play. The article traces the metamorphoses Fortinbras undergoes in his afterlife in Germany from the mid-nineteenth century through the First and Second World Wars to the fall of the Berlin Wall in 1989.
Усунення надлишкового бактеріального росту в тонкій кишці як допоміжний метод лікування цукрового діабету 2 типу
Authors: Ткач С. М. , Доготар В. Б. 
Published: December 2022

Досліджень, присвячених вивченню частоти синдрому надмірного бактеріального росту (СНБР) у хворих на цукровий діабет (ЦД) 2 типу, мало, а їх результати мають неповний і суперечливий характер. Є лише поодинокі наукові праці щодо впливу усунення СНБР на перебіг ЦД 2 типу.
Мета роботи — уточнити частоту синдрому надлишкового бактеріального росту та значення його усунення у хворих на цукровий діабет 2 типу.
Матеріали та методи. Обстежено 108 пацієнтів із ЦД 2 типу (60 чоловіків і 48 жінок) віком від 32 до 65 років (середній вік — (45 ± 18) років), в яких спостерігалися такі гастроінтестинальні симптоми, як здуття та біль у животі, а також порушення випорожнення. Також обстежено 30 клінічно здорових осіб (середній вік — (33 ± 12) років). Усім хворим для діагностики СНБР проводили Н2‑дихальний тест з лактулозою (Н2‑ЛДТ). Пацієнтів з позитивними результатами Н2‑ЛДТ (50 пацієнтів) простим сліпим методом залежно від лікування рандомізували на дві групи. У першій групі 24 пацієнти продовжували отримувати раніш призначену базисну пероральну цукрознижувальну терапію, у другій групі 26 пацієнтам додатково до базисної терапії для усунення СНБР призначали рифаксимін‑a («Альфа Нормікс») у добовій дозі 1200 мг протягом 14 днів. Первинним критерієм ефективності лікування вважали частку пацієнтів з негативним результатом Н2‑ЛДТ після лікування, вторинними критеріями — частку пацієнтів з клінічним поліпшенням (зменшення абдомінального болю, здуття та порушень випорожнення) через 2 тиж лікування, а також пацієнтів з компенсацією ЦД через 2 міс після закінчення лікування.
Результати. За результатами Н2‑ЛДТ, наявність СНБР зафіксовано у 50 із 108 хворих на ЦД 2 типу (46,3 %) та 2 (6,6 %) осіб із контрольної групи. Частота СНБР зростала у хворих з тривалішим перебігом ЦД 2 типу та його субкомпенсацією і декомпенсацією. Додаткове призначення хворим на ЦД 2 типу із супутнім СНБР рифаксиміну‑a у дозі 1200 мг/добу протягом 14 днів було безпечним та добре переносилося, у 76,9 % випадків — сприяло ерадикації СНБР, у 73,8 % — супроводжувалось клінічним ефектом, у 80,8 % — протягом наступних 2 міс сприяло компенсації ЦД 2 типу, що статистично значущо більше, ніж в контрольній груп.
Висновки. Синдром надлишкового бактеріального росту діагностували у значної кількості (46,3 %) хворих на ЦД 2 типу, що підтверджує припущення, що кишковий дисбіоз і зокрема СНБР можуть відігравати важливу роль у патогенезі ЦД 2 типу. За наявності СНБР додаткове до базисної пероральної цукрознижувальної терапії призначення рифаксиміну‑a у добовій дозі 1200 мг протягом 2 тиж сприяло його зникненню та клінічному поліпшенню у більшості хворих, а також розвитку компенсації ЦД. Рифаксимін‑a можна розглядати як безпечний та ефективний додатковий патогенетичний засіб лікування хворих на ЦД 2 типу із супутнім СНБР.
Метаболічні ефекти інгібіторів натрійзалежного котранспортера глюкози 2 типу
Authors: Кедик А. В. , Куцин О. О. 
Published: December 2022

В огляді літератури розглядається нова універсальна молекула емпагліфлозину, якій вдалося змінити глюкозоцентричний підхід в ендокринології на органопротекторний. Результати базових клінічних досліджень, проведених з емпагліфлозином (EMPA‑REG‑OUTCOME, EMPEROR‑REDUCED, EMPEROR‑PRESERVED та EMPULSE), дають підстави стверджувати про здатність емпагліфлозину знижувати випадки серцево‑судинної смерті або госпіталізацію з приводу серцевої недостатності та уповільнювати прогресування хронічної хвороби нирок. Серед підтверджених і потенційно сприятливих метаболічних наслідків прийому емпагліфлозину слід зазначити такі: вибірковий антигіперглікемічний ефект лише в умовах гіперглікемії/глюкозурії, що не залежить ані від продукції інсуліну, ані від чутливості периферичних тканин до інсуліну, а лімітований лише швидкістю клубочкової фільтрації. Цей ефект дає змогу уникати гіпоглікемії навіть у пацієнтів без діабету. Препарат є одним з найбільш довговічних серед пероральних цукрознижувальних засобів і дає змогу протягом 6 — 8 років утримувати досягнуті значення глікозильованого гемоглобіну, відтерміновуючи ініціацію інсулінотерапії у пацієнтів із цукровим діабетом 2 типу. Емпагліфлозин у пацієнтів із цукровим діабетом 2 типу переважав плацебо щодо запобігання смертності внаслідок серцево‑судинних захворювань, нелетального інфаркту міокарда або нелетального інсульту. Ефект спричинений значним зниженням ризику серцево‑судинної смертності без суттєвих змін щодо нелетального інфаркту міокарда або нелетального інсульту. Можливе поєднання з іншими пероральними та ін’єкційними цукрознижувальними препаратами. У разі поєднання з препаратами сульфонілсечовини або інсуліном, останні потребують корекції дози у бік її зменшення. Втрата 2 — 3 кг маси тіла на тлі емпагліфлозину є очікуваним явищем, яке може модифікувати показники артеріального тиску та резистентність до інсуліну. Емпагліфлозин має здатність знижувати стеатоз та поліпшувати показники фіброзу печінки у пацієнтів з неалкогольною жировою хворобою печінки без цукрового діабету 2 типу.
The folate-centric concept of pathogenesis and GBINC personalized multidisciplinary approach to the clinical management of children with neuropsychiatric syndromes. Review
Authors: Maltsev D. V. 
Published: December 2022

Solving the problem of children’s neuropsychiatric diseases is a priority task of modern medicine. The latest scientific achievements in the field of genetics, molecular biology and immunology, which demonstrate biochemical and immune‑dependent ways of formation of human neuropsychiatric disorders, shed light on the mechanisms of brain damage in children with ASD. These research give reason for optimism about overcoming this severe psychiatric pathology in the future thanks to the implementation of genetic, biochemical and immunodiagnostic approaches, as well as metabolic and immunotherapeutic interventions with neuroprotective effects. Currently, the folate‑centric concept of polygenic inheritance of predisposition to the development of neuropsychiatric syndromes in children with multisystem damage has been established. Biochemical and immune‑dependent (infectious, autoimmune, immunoinflammatory, and allergic) pathways of microbe‑induced autoimmune inflammatory encephalopathy with neuropsychiatric clinical manifestations are discussed in the context of the folate‑centric concept. Taking into account the new data, two personalized multidisciplinary approaches to the management of children with ASD and other neuropsychiatric syndromes are proposed. The first approach of J. J. Bradstreet et al. (2010) is based on the empirical analysis of a large group of laboratory biomarkers, the relevance of which has been demonstrated in clinical studies, and the targeted correction of abnormalities identified by biomarkers (so‑called biomarker‑guided interventions). In 2022, Frye R. developed a multidisciplinary personalized approach called BaS‑BiSTOR (collect Baseline data, search for Symptoms, measure Biomarkers, Select Treatment, Observe for Response), which systematizes and stratifies diagnostic and treatment interventions based on the assessment of biomarkers. In order to improve existing recommendations regarding specific subtypes of neuropsychiatric syndromes in children, this article proposes an improved personalized multidisciplinary approach to the clinical management of patients with autistic spectrum disorders and neuropsychiatric manifestations associated with genetic deficiency of the folate cycle, called GBINS (Genetic‑Biochemical‑Immunological‑Neurological‑Symptomatic evaluation). There are reasons to believe that the successful testing in clinical practice of evidence‑based personalized multidisciplinary diagnostic and treatment strategies will allow making a breakthrough in the clinical management of children with severe mental disorders in the near future, which will provide not only the possibility of recovery from a prognostically unfavorable and currently incurable neuropsychiatric disorder, but also and will contribute to stopping the large‑scale threatening epidemic of neuropsychiatric syndromes in the modern child population.
DNA TYPING BY TELOMERASE REVERSE GENE TRANSCRIPTASE (TERT)
Authors: Saienko A. M. , Balatsky V. N. , Budakva Ye. O. , Peka M. Y. , Korinnyi S. M. 
Published: December 2022

The length of the telomeric DNA and polymorphism of the TERT (Telomerase Reverse Transcriptase) gene can be the basis for the development of molecular genetic markers for the productive traits of agricultural animals, in particular pigs.
The purpose of the work was to analyze the databases of the primary structure of the pig TERT gene, to determine single nucleotide polymorphisms (SNPs), to develop a DNA system for animal typing based on the TERT gene.
Samples of biomaterials (blood, bristles) for DNA typing were selected from the leading farms of Ukraine in groups of 4 breeds of pigs and hybrid animals. Isolation of DNA from biomaterial was carried out using the Chelex 100 reagent. Genotyping of animals by the telomerase locus was carried out on the basis of standard methods of polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The alignment of nucleotide sequences during the analysis of the primary structure of the TERT gene was carried out using the MegaX software and the Blast service. Design of the structure of oligonucleotide primers for PCR was carried out using the computer program Primer3Plus.
During the development of the method of pigs genotyping according to TERT gene, a database analysis was carried out regarding the primary structure of the gene, a region of the gene with a significant number of SNPs was identified, and oligonucleotide primers were designed for PCR amplification of this region of the gene. The study presents the conditions of amplification of the TERT gene fragment, its cleavage by restriction endonuclease RsaI at the location of SNP rs698799571, electrophoresis of the obtained restriction DNA fragments in an 8% polyacrylamide gel, and the genotypes of the animals are also determined. The developed DNA typing technique for the TERT gene was used to analyze its polymorphism in groups of 4 purebred pigs and a group of hybrid anjmals. Monomorphic homozygous TERTAA genotype was present in purebred pigs. The polymorphism of the TERT gene by SNP rs698799571 was detected in a group of pigs of the final Irish hybrid (LW x L) x Maxgro (TERTAT genotype).
Considering the fact that studies on the telomerase gene and determination of the TERT polymorphism for SNP rs698799571 in pigs have not yet been conducted in Ukraine, the developed technique of DNA typing by the telomerase gene has a perspective for further determination of the distribution of alleles and genotypes in domestic and imported breeds, as well as in marker-associated selection.
IN MEMORY OF HRYHORII SEMENOVYCH SHARAPA (1933–2022) – A RECOGNIZED UKRAINIAN SCIENTIST IN THE FIELD OF FARM ANIMAL REPRODUCTION
Authors: Kovtun S. I. , Borodai I. S. , Shcherbak O. V. 
Published: December 2022

The purpose of the article is to highlight the life path and creative pursuits of Candidate of Biological Sciences, Honored Worker of Agriculture of Ukraine H. S. Sharapa in the field of reproductive biotechnology of the farm animals and improvement of artificial insemination techniques. Research methods are general scientific (analysis, synthesis, classification), special historical (problematic-chronological, comparative-historical, biographical), source studies. The scientific novelty of the article lies in the systematization of the scientific heritage of the scientist and the generalization of creative achievements that have found wide practical application in the field of animal husbandry. It is substantiated that H. S. Sharapa has made a significant contribution to the study of the anatomical and physiological characteristics of the genital organs of cows, sheep and bulls of domestic breeds of cattle, to the improvement of the technique of insemination of females. Scientists have developed effective methods of increasing the reproductive capacity of breeding animals, optimal modes of their sexual load, modes of conservation and use of sperm, technology of artificial insemination of cows and heifers; a number of diagnostic, preventive and treatment measures for gynecological diseases were proposed, which contributed to the increase in the profitability of the production of livestock products in Ukraine. H. S. Sharapa made efforts to organize research work in animal husbandry as the Head of the Laboratory of Breeding Biology of Farm Animals of the Kyiv Research Station of Animal Husbandry "Terezyne" and relevant departments of the Institute of Animal Breeding and Genetics named after M.V.Zubets of NAAS. The creative approaches of the scientist in the field of spreading zootechnical education and popularizing the scientific achievements of Ukrainian scientists in the field of reproductive biotechnology are summarized.
Dealing with Crucial Aspects of Action Research
Authors: Sharma Lok Raj 
Published: December 2022

Action research, which is a dynamic iterative process, is a deliberate and solution-oriented investigation accomplished collectively or personally in order to solve an existing problem. It entails the participants who scrutinize their own instructive practice systematically and cautiously. It is characterized by spiraling cycles of problem identification, systematic data collection, reflection, analysis, actions taken based on data, and finally problem redefinition. It is an applied form of inquiry useful in divergent situations. It involves such people who keep working to improve their performances, skills, strategies and techniques. The prime objective of this article is to deal with the crucial aspects of action research, such as definitions of action research, field of action research, process, steps, principals, characteristics, benefits and demerits of action research. This article has been prepared on the basis of secondary data gathered from research books and journal articles. It is useful especially to the researchers, because it focuses on the indispensable aspects of action research, and it is undoubtedly necessary for them to have basic ideas about its underlying facets to carry out action researches in their real life situations.
Nutrient contents in different sources of organic manures used in different farms of Bhaktapur district, Nepal
Authors: Sharma Reena , Kandel Saraswoti , Khadka Sujan , Chaudhary Suraj 
Published: December 2022

Organic manure contributes carbonaceous matter to soil, which when decomposed, offers mineral nutrients to plants, also acts as a base exchange material, and helps to improve the physical, chemical, and biological aspects of soil. This study was conducted to assess the amount of total nitrogen, available phosphorous, available potassium, pH, under various organic manure sources. Collected organic matter samples were tested for total nitrogen, available phosphorus, available potassium, soil organic matter, and pH at the soil laboratory of Nepal Polytechnic College, Bharatpur-11, Chitwan, using the NARC, Soil Science Research Centre, Khumaltar, Lalitpur standard rating. The overall nitrogen concentration of goat dung was 1.667%, whereas buffalo manure had the lowest at 0.665%. The available phosphorus content of organic manure in the research area ranged from 0.732% in vermi-compost to 0.432% in compost, with substantial differences amongst manure samples. The goat manure had the highest potassium level (0.853%), whereas buffalo manure had the lowest (0.513%). The pH value of goat manure was 8.4 while the pH content of compost manure was 7.567. The maximum amount of organic matter (54.8) was found in buffalo manure, while the lowest (46.3) was found in vermi compost. The maximum amount of organic matter (54.8%) was found in buffalo manure, while the lowest (46.3%) was found in vermi compost. Modern technology must be adapted for successful and improved manure production. To increase the availability and maintenance of nutrients in organic manure, methods such as covering the manure to protect it from rain and sun, avoiding waterlogged conditions, and correct manure decomposition can be implemented.
Efficacy of Trichoderma isolates against Sclerotium rolfsii causing collar rot of lentil
Authors: Aryal Laxman , Baidya Suraj , Subedi Subash 
Published: December 2022

Lentil collar rot disease caused by Sclerotium rolfsii Sacc. is an important disease causing significant yield loss in Nepal. Seven Trichoderma spp. isolates collected from different regions of Nepal were tested for their capacity to inhibit mycelial growth of Sclerotium rolfsii in in-vitro condition. Experiment was conducted in Completely Randomized Design with four replications in the plant pathology laboratory of Grain Legumes Research Program, Khajura, Banke during 2020. Dual culture method was performed to assess the efficacy of Trichoderma isolates. Trichoderma spp. isolates inhibited mycelial growth of S. rolfsii to various degrees ranging from 48.33-72.47% after 120 hours of inoculation. Maximum colony inhibition of S. rolfsii (72.47%) was obtained by Kapilvastu isolate followed by Nepalgunj isolate (67.72%). Minimum colony inhibition of S. rolfsii (48.33%) was obtained by Mangalpur, Chitwan isolate followed by Rampur, Chitwan isolate (49.33%). Among seven Trichoderma isolates, two isolates (Kapilbastu and Nepalgunj) showed good antagonistic activity against S. rolfsii and were also highly competitive in in-vitro condition. These isolates would therefore be useful in biological disease management.
Factors Affecting Work Life Balance: A Case Study of Himalayan Bank Ltd.
Authors: Bhandari Sunita 
Published: December 2022

Service oriented organizations are focusing themselves on providing effective services via satisfied and customer friendly employees. Himalayan Bank, being one of the reputed commercial private bank in Nepal has a challenge to become an employee-friendly organization for providing quality services to customers. This research is carried out to find the factors that influence the effectiveness of the employees who are responsibly working for the quality, image and prospect of the organization. This article is mainly focused on exploring family responsibilities as well as work responsibilities which have impact on the job satisfaction of the employees working permanently in the bank. Primary data used in this study have been collected through the structured questionnaire distributed to selected employees. Collected data are analyzed by using excel and SPSS. Cronbach’s alpha is calculated to see the reliability of the items used as the instrument to measure variables. Correlation, t-test, regression analysis, F-test as well as post hoc analysis are done to examine the status and impact of variables. Most of the independent variables taken into consideration are found to have significant impact on the dependent variable. Practical and theoretical implications in work life balance is prescribed for practical and theoretical implications in the future.