bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incoherent and Indefensible? A Normative Analysis of Young People’s Position in England’s Welfare and Homelessness Systems
Authors: Colliver Kit 
Published: May 2023

Abstract
Young people experience different treatment compared to older adults in the English welfare and homelessness systems, encountering varying levels of protection and disadvantage. This paper uses a value-pluralist perspective to explore the normative rationales for and the ethical defensibility of these policy differences. Evidence from 38 key informant interviews suggests that the English homelessness system is shifting towards a vulnerability-oriented response to young people. But an inconsistent value framework within the welfare system systematically disadvantages them without offering a corresponding degree of protection. As such, these closely-connected areas of social policy pull in opposing directions. Although individual positions targeting young people may (to greater and lesser extents) be justifiable, this disparity in values creates an incoherent and indefensible welfare policy landscape for this group.
How Incarcerating Children Affects their Labour Market Outcomes
Authors: Dorsett Richard , Thomson David 
Published: May 2023

Abstract
We investigate the labour market effects of incarcerating children. Using linked administrative data to track outcomes for English schoolchildren, we estimate an econometric model of transitions between education, custody, employment and NEET (not in employment, education or training), along with earnings for those starting work. We allow outcomes to vary according to the individual’s state in the preceding spell and, by controlling for personal characteristics and unobserved heterogeneity, interpret such variation as capturing causal impacts. For males, the main effect of incarceration is a reduction of more than 10% in the probability of employment. For females, there is no overall impact on employment but, for those entering work, wages are reduced by 25%. These negative impacts suggest roles for policy in deterring delinquency, finding alternatives to custody, rehabilitating those incarcerated and supporting resettlement on release. Appropriate labour market policy may differ by gender, with males needing help to overcome employer discrimination and females needing encouragement to achieve better-paid work.
Hip-hop sampling aesthetics and the legacy ofGrand Upright v. Warner
Authors: Mcleish Claire E.A. 
Published: May 2023

AbstractIn 1991, Gilbert O'Sullivan sued Biz Markie for sampling without permission: this lawsuit,Grand Upright v. Warner, became a landmark case for music copyright, and for some scholars, represented a symbolic end to hip hop's golden age. This paper uses the lawsuit as a point of entry into debates about hip hop during a time of aesthetic transformation. Specifically, I present a corpus study spanning 1988–1993, consisting of hip hop songs of various subgenres drawn from Billboard charts. Unlike previous studies on this period, I consider both canonical artists, whose mastery of sampling is widely admired (such as Public Enemy), and more commercially successful artists (like the Fresh Prince), who used fewer samples. My study reveals a decrease in the average number of samples per song, and a radical shift in how these remaining samples are used. I situate Grand Upright at the intersection of legal institutions and musical aesthetics
Compliant peg-in-hole assembly for nonconvex axisymmetric components based on attractive region in environment
Authors: Liu Yang , Chen Ziyu , Qiao Hong , Gan Shuai 
Published: May 2023

AbstractWith the development of intelligent manufacturing, more and more nonstandard parts are used in high-precision assembly. The robotic assembly method based on attractive region in environment (ARIE) has been proven to have good performance in the high-precision assembly under the limitation of robot system accuracy or sensing accuracy. However, for the assembly of nonstandard parts, especially nonconvex parts, the existing ARIE-based strategy lacks a targeted design. In the assembly process, the nonconvex structure may cause blocking problems, which will lead to assembly failure when using the strategy. In order to solve this problem, this paper proposes a new assembly method by using the geometric features of constraint region based on the concept of ARIE. Specifically, first, when using the ARIE-based classic strategy, the reasons for the possible blocking problem in the assembly of a class of nonconvex axisymmetric parts are analyzed in detail. Second, a multi-step sliding strategy is proposed based on the theory of ARIE to solve the possible blocking problem in the assembly process. Third, impedance control is used to enable the peg to achieve the desired compliant motion in the proposed strategy. The improvement in the success rate of the proposed method is verified by the comparison experiment of small clearance peg-in-hole assembly, where the structure of the peg is nonconvex and axisymmetric.
Investigating the vision-based intervertebral motion estimation of the Cadaver’s craniovertebral junction
Authors: Zubair Mohammad , Kansal Sachin , Mukherjee Sudipto 
Published: May 2023

AbstractCraniovertebral junction (CVJ) is one of the more complex parts of the spinal column. It provides mobility to the cranium and houses the spinal cord. In a healthy subject, the CVJ contributes 25% of the flexion–extension motion and 50% of the axial rotation of the neck. This work reports instrumentation development and results for evaluating implant performance in the stabilized CVJ after surgical procedures. Typically, some bony parts of the vertebrae causing compression to the spinal cord are removed and subsequently stabilized by the instrumenting implant in the CVJ. Pose estimation of the Cadaveric CVJ region is estimated using a monocular vision-based setup. The cervical spine’s first three vertebrae surround the CVJ area, where most cervical spine mobility originates. We aim to evaluate the performance of vision-based intervertebral motion estimation of the Cadaver’s CVJ in the Indian population, particularly in older people. A series of tests were performed on the Cadaver’s CVJ to evaluate the vision system-based motion estimation performance.
Theoretical study on a modified rocker-bogie suspension for robotic rovers
Authors: Cosenza Chiara , Niola Vincenzo , Pagano Stefano , Savino Sergio 
Published: May 2023

AbstractRobotic rovers equipped with articulated rocker-bogie suspension have aroused great interest after the explorations on Mars; this interest has also shifted to different types of terrestrial applications such as in the agriculture, military, and rescue fields. The suspension can be designed so that, when the rover is on flat and horizontal ground, the weight is evenly distributed among the wheels; in this way, all wheels have the same traction capability and offer the same rolling resistance. As the operating conditions vary due to sloping ground, uneven ground surface, or different payload position, the weight distribution can undergo considerable variations. This type of suspension is statically determined with respect to weight, but it is indeterminate with respect to traction forces; the traction control system aims to avoid the wheels slippage. In this paper, the traction contribution that each wheel can provide, to overcome a step obstacle, is shown. Furthermore, the possibility of regulating the distribution of vertical loads among the wheels adopting a torsion spring, with adjustable preload, arranged between rocker and bogie, is evaluated. A suitable spring preload facilitates the initial phase of the obstacle overcoming if the rover advances with the bogie forward. Numerical simulations show that to increase the possibility of overcoming an obstacle it is sufficient for the spring preload to reduce the vertical load on the front wheel; in any case, a higher load variation would not be advisable as it could involves an excessive load difference among the wheels.
Estimating reliability for response-time difference measures: Toward a standardized, model-based approach
Authors: Hui Bronson , Wu Zhiyi 
Published: May 2023

AbstractA slowdown or a speedup in response times across experimental conditions can be taken as evidence of online deployment of knowledge. However, response-time difference measures are rarely evaluated on their reliability, and there is no standard practice to estimate it. In this article, we used three open data sets to explore an approach to reliability that is based on mixed-effects modeling and to examine model criticism as an outlier treatment strategy. The results suggest that the model-based approach can be superior but show no clear advantage of model criticism. We followed up these results with a simulation study to identify the specific conditions in which the model-based approach has the most benefits. Researchers who cannot include a large number of items and have a moderate level of noise in their data may find this approach particularly useful. We concluded by calling for more awareness and research on the psychometric properties of measures in the field.
Manipulating device-to-body forces in passive exosuit: An experimental investigation on the effect of moment arm orientation using passive back-assist exosuit emulator
Authors: Bhardwaj Siddharth , Shinde Akshayraj B. , Singh Randheer , Vashista Vineet 
Published: May 2023

AbstractPassive exosuits have been vastly researched in the past decade for lifting tasks to alleviate the mechanical loading on the spine and reduce the lower back muscle activities in lifting tasks. Despite promising advantages of exosuits, factors such as comfort directly influence the user’s acceptability of such body-worn devices. Exosuits’ routing/anchoring points, which transmit device-to-body forces, remain the leading cause of discomfort among users. In the present study, we sought to investigate the effect of the routing element, that is, the “moment arm,” in altering the device-to-body forces and perceived discomfort. We first presented a simplified human–exosuit model to establish insight into the effect of the moment arm on the device-to-body forces acting at the shoulder (FS) and waist (FW). Further, an experimental investigation was conducted on 10 participants with six different exosuit moment arm configurations (C1, C2, C3, C4, C5, and C6) to investigate their effect on the device-to-body forces, perceived discomfort, and muscle activity using a passive back-assist exosuit emulator in a lifting/lowering task. Configuration C4 was found to be most beneficial in reducing device-to-body forces at the shoulder and waist by up to 44.6 and 22.2%, respectively, during lifting. Subjective scores also comprehended with the device-to-body forces, indicating that C4 produces significantly less discomfort for participants. The outcome of the study illustrates the importance of selecting an appropriate moment arm configuration for passive back support exosuits in alleviating the device-to-body forces and perceived discomfort.
Investigating Spectral Estimates of Stress Drop for Small to Moderate Earthquakes With Heterogeneous Slip Distribution: Examples From the 2016–2017 Amatrice Earthquake Sequence
Authors: Calderoni Giovanna , Abercrombie Rachel E. 
Published: May 2023

AbstractEstimates of spectral stress drop are fundamental to understanding the factors controlling earthquake rupture and high frequency ground motion, but are known to include large, poorly‐constrained uncertainties. We use earthquakes from the 2016–2017 sequence in the Italian Appenines (largest event at Norcia, Mw 6.3) to investigate these uncertainties and their causes. The similarly‐sized events near Amatrice (Mw 6.0) and Visso (Mw 5.9) enable better constrained relative analysis. We calculate S wave source spectra, corner frequencies, and spectral stress drop for 30 of the larger events. We compare both empirical and modeling approaches to isolate the source spectra and calculate source parameters; we also compare our results with those from published studies. Both random and systematic inter‐study variations are larger than the standard errors reported by any individual study. The reported magnitude dependence of stress drop varies between studies, being largest for generalized inversions and smallest for more individual event based approaches. The relative spectral estimates of inter‐event stress drop are more consistent; all approaches estimated higher stress drop in the Amatrice earthquake than the similar‐sized Visso earthquake. In contrast, finite fault inversions of these two earthquakes found that the Visso earthquake had the larger region of concentrated, higher slip, whereas the Amatrice earthquake had multiple, lower slip, subevents. The Amatrice spectra contain more high frequency energy than those of the Visso earthquake. This comparison suggests that consistent measurement of a higher spectral stress drop indicates greater high‐frequency ground motion but may correspond to greater rupture complexity rather than higher stress drop.
Downwind Ozone Changes of the 2019 Williams Flats Wildfire: Insights From WRF‐Chem/DART Assimilation of OMI NO2, HCHO, and MODIS AOD Retrievals
Authors: Pouyaei Arman , Mizzi Arthur P. , Choi Yunsoo , Mousavinezhad Seyedali , Khorshidian Nima 
Published: May 2023

AbstractThis study investigates the impacts of the Williams Flats wildfire (August 3‐9, 2019) on ozone conccentrations and chemistry in the downwind region using an assimilation framework with satellite retrievals and meterological measurements. By assimilating satellite‐retrieved nitrogen dioxide (NO2) and formaldehyde (HCHO) columns, we improve surface ozone simulations (index of agreement of 0.94 compared to station measurements) and utilize aerosol optical depth (AOD) retrievals to simulate spatial dynamics of wildfire plumes better. Comparing simulated ozone with the Fire Influence on Regional to Global Environments and Air Quality aircraft measurements reveals a fair simulation of ozone in smoke and non‐smoke plumes within the lower troposphere (7.00 ppbv mean absolute error). Comparing near‐distance and far‐distance locations, the study observed higher‐than‐average concentrations of nitrogen oxides, peroxyacetyl nitrate, nitric acid, and oxygenated volatile organic compounds due to wildfire emissions, which increased ozone concentrations by 3–5 ppbv during the wildfire in near‐distance locations and 2–3 ppbv in far‐distance locations. During more intense wildfire days, above 120 ppbv carbon monoxide plumes transported over the Rocky Mountains to the east. Ozone regime indicators showed a clear transition area downwind of the wildfire region that exacerbated the formation of ozone downwind. Our findings suggest that a joint assimilation of NO2 column, HCHO column, and AOD can enhance our understanding of wildfire‐associated ozone chemistry and dynamics.
WWOX binds MERIT40 and modulates its function in homologous recombination, implications in breast cancer
Authors: Taouis Karim , Vacher Sophie , Guirouilh-Barbat Josée , Camonis Jacques , Formstecher Etienne , Popova Tatiana , Hamy Anne-Sophie , Petitalot Ambre , Lidereau Rosette , Caputo Sandrine M. , Zinn-Justin Sophie , Bièche Ivan , Driouch Keltouma , Lallemand François 
Published: May 2023

AbstractThe tumor suppressor gene WWOX is localized in an unstable chromosomal region and its expression is decreased or absent in several types of cancer. A low expression of WWOX is associated with a poor prognosis in breast cancer (BC). It has recently been shown that WWOX contributes to genome stability through its role in the DNA damage response (DDR). In breast cancer cells, WWOX inhibits homologous recombination (HR), and thus promotes the repair of DNA double-stranded breaks (DSBs) by non-homologous end joining (NHEJ). The fine-tuning modulation of HR activity is crucial. Its under or overstimulation inducing genome alterations that can induce cancer. MERIT40 is a positive regulator of the DDR. This protein is indispensable for the function of the multi-protein complex BRCA1-A, which suppresses excessive HR activity. MERIT40 also recruits Tankyrase, a positive regulator of HR, to the DSBs to stimulate DNA repair. Here, we identified MERIT40 as a new molecular partner of WWOX. We demonstrated that WWOX inhibited excessive HR activity induced by overexpression of MERIT40. We showed that WWOX impaired the MERIT40-Tankyrase interaction preventing the role of the complex on DSBs. Furthermore, we found that MERIT40 is overexpressed in BC and that this overexpression is associated to a poor prognosis. These results strongly suggest that WWOX, through its interaction with MERIT40, prevents the deleterious impact of excessive HR on BC development by inhibiting MERIT40-Tankyrase association. This inhibitory effect of WWOX would oppose MERIT40-dependent BC development.
Electroacupuncture prevents astrocyte atrophy to alleviate depression
Authors: Lin Si-Si , Zhou Bin , Chen Bin-Jie , Jiang Ruo-Tian , Li Baoman , Illes Peter , Semyanov Alexey , Tang Yong , Verkhratsky Alexei 
Published: May 2023

AbstractAstrocyte atrophy is the main histopathological hallmark of major depressive disorder (MDD) in humans and in animal models of depression. Here we show that electroacupuncture prevents astrocyte atrophy in the prefrontal cortex and alleviates depressive-like behaviour in mice subjected to chronic unpredictable mild stress (CUMS). Treatment of mice with CUMS induced depressive-like phenotypes as confirmed by sucrose preference test, tail suspension test, and forced swimming test. These behavioural changes were paralleled with morphological atrophy of astrocytes in the prefrontal cortex, revealed by analysis of 3D reconstructions of confocal Z-stack images of mCherry expressing astrocytes. This morphological atrophy was accompanied by a decrease in the expression of cytoskeletal linker Ezrin, associated with formation of astrocytic leaflets, which form astroglial synaptic cradle. Electroacupuncture at the acupoint ST36, as well as treatment with anti-depressant fluoxetine, prevented depressive-like behaviours, astrocytic atrophy, and down-regulation of astrocytic ezrin. In conclusion, our data further strengthen the notion of a primary role of astrocytic atrophy in depression and reveal astrocytes as cellular target for electroacupuncture in treatment of depressive disorders.
Tests for associations between sexual dimorphism and patterns of quantitative genetic variation in the water strider, Aquarius remigis
Authors: Fairbairn Daphne J. , Roff Derek A. , Wolak Matthew E. 
Published: May 2023

AbstractThe evolution of sexual dimorphisms requires divergence between sexes in the evolutionary trajectories of the traits involved. Discerning how genetic architecture could facilitate such divergence has proven challenging because of the difficulty in estimating non-additive and sex-linked genetic variances using traditional quantitative genetic designs. Here we use a three-generation, double-first-cousin pedigree design to estimate additive, sex-linked and dominance (co)variances for 12 traits in the water strider, Aquarius remigis. Comparisons among these traits, which have size ratios ranging from 1 to 5 (larger/smaller), allow us to ask if sexual dimorphisms are associated with characteristic patterns of quantitative genetic variation. We frame our analysis around three main questions, derived from existing theory and empirical evidence: Are sexual dimorphisms associated with (1) lower additive inter-sex genetic correlations, (2) higher proportions of sex-linked variance, or (3) differences between sexes in autosomal additive and dominance genetic variances? For questions (1) and (2), we find weak and non-significant trends in the expected directions, which preclude definitive conclusions. However, in answer to question (3), we find strong evidence for a positive relationship between sexual dimorphism and differences between sexes in proportions of autosomal dominance variance. We also find strong interactions among the three genetic components indicating that their relative influence differs among traits and between sexes. These results highlight the need to include all three components of genetic (co)variance in both theoretical evolutionary models and empirical estimations of the genetic architecture of dimorphic traits.
Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae
Authors: Han Fangzhu , Hu Yiqi , Wu Mengchen , He Zhaoxiang , Tian Hongtao , Zhou Long 
Published: May 2023

AbstractTetrahymena thermophila, a classic ciliate model organism, has been shown to possess tubular mitochondrial cristae and highly divergent electron transport chain involving four transmembrane protein complexes (I–IV). Here we report cryo-EM structures of its ~8 MDa megacomplex IV2 + (I + III2 + II)2, as well as a ~ 10.6 MDa megacomplex (IV2 + I + III2 + II)2 at lower resolution. In megacomplex IV2 + (I + III2 + II)2, each CIV2 protomer associates one copy of supercomplex I + III2 and one copy of CII, forming a half ring-shaped architecture that adapts to the membrane curvature of mitochondrial cristae. Megacomplex (IV2 + I + III2 + II)2 defines the relative position between neighbouring half rings and maintains the proximity between CIV2 and CIII2 cytochrome c binding sites. Our findings expand the current understanding of divergence in eukaryotic electron transport chain organization and how it is related to mitochondrial morphology.
Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice
Authors: Ramos-Pittol Jose M. , Fernandes-Freitas Isabel , Milona Alexandra , Manchishi Stephen M. , Rainbow Kara , Lam Brian Y. H. , Tadross John A. , Beucher Anthony , Colledge William H. , Cebola Inês , Murphy Kevin G. , Miguel-Aliaga Irene , Yeo Giles S. H. , Dhillo Waljit S. , Owen Bryn M. 
Published: May 2023

AbstractCoupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to restrain kisspeptin (KISS1)-neuron pulsatility in the arcuate hypothalamic nucleus, while also exerting a surge-like effect on KISS1-neuron activity in the AVPV hypothalamic nucleus. However, a mechanistic basis for this region-specific effect has remained elusive. Our genomic analysis in female mice demonstrate that some processes, such as restraint of KISS1-neuron activity in the arcuate nucleus, may be explained by region-specific estrogen receptor alpha (ERα) DNA binding at gene regulatory regions. Furthermore, we find that theKiss1-locus is uniquely regulated in these hypothalamic nuclei, and that the nuclear receptor co-repressor NR0B1 (DAX1) restrains its transcription specifically in the arcuate nucleus. These studies provide mechanistic insight into how ERα may control the KISS1-neuron, andKiss1gene expression, to couple gonadotropin release to the developmental stage of the oocyte.