bluuebunny/crossref_metadata_2025_split huggingface dataset:
VZV gE Promotes STING Degradation via Midnolin-Proteasome Pathway to Inhibit cGAS-STING Signaling
Authors: Chen Lumiao , Dai Lingao , Nie Shenghao , Zhao Yue , Li Fanyuan , Deng Xiujiao , Liu Chunlin , Li Moran , Luo Zewei , Liu Yuqing , Ge Weiwei , Liu Xiaofei , Yi Qian , Li Yongkui , Pan Pan , Wang Xiaoping 
Published: January 2025

AbstractVaricella-zoster virus (VZV) infects 85 million individuals annually and it is known for its intricate interplay with host cellular mechanisms, significantly impacting antiviral immune responses. Previous studies have highlighted the critical role of VZV glycoprotein E (gE) in virus-host interactions, but the precise mechanisms remain to be elucidated. Our results demonstrate that VZV gE interacts with STING, specifically through the gE (350-480aa) and STING (151-160aa) regions. This interaction predominantly involves incompletely glycosylated gE. Functional assays revealed that gE inhibits the cGAS-STING signaling pathway. gE enhances VZV proliferation and promotes STING degradation via the proteasome pathway, without affecting STING ubiquitination. We identified Midnolin as a mediator in this degradation process, with gE facilitating the interaction between STING and Midnolin. In vivo, gE expression in mice led to diminished antiviral responses upon HSV-1 infection, highlighting gE’s role in modulating immune signaling. Our findings provide significant insights into VZV’s evasion of host immune responses. By promoting STING degradation through an unconventional Midnolin-proteasome pathway, VZV gE effectively suppresses antiviral signaling, facilitating enhanced viral proliferation. The findings contribute significantly to the understanding of VZV pathogenesis and provide new therapeutic strategies against VZV.
A starvation-triggered AAA+ ATPase halts chromosome replication progression by disassembling the bacterial DNA sliding clamp
Authors: Surbhi  , Shau Arnab Kumar , Chacko Feby Mariam , Radhakrishnan Sunish Kumar 
Published: January 2025

AbstractLiving cells should coordinate vital events such as DNA replication with the availability of nutrients. For example, when cells encounter starvation, to maintain genomic integrity they should harbour robust mechanisms to stop DNA replication. Mechanisms regulating the progression of DNA replication when bacterial cells encounter starvation remain largely unclear. Herein, we identify the role of IncA –a AAA+ ATPase homologous to the prokaryotic RarA and eukaryotic WRNIP1/Mgs1– in inhibiting the progression of chromosome replication in nutrient-starved stationary phase cells ofCaulobacter crescentus. We show that the starvation-induced alarmone (p)ppGpp ensures the confinement of IncA production to the stationary phase cells. At the mechanistic level, IncA directly interacts with the β-sliding clamp protein DnaN and disassembles DnaN from the replisome, thereby stalling the progression of DNA replication. Furthermore, we reveal the requirement of IncA’s ATPase activity for disassembling DnaN. Remarkably, we demonstrate that the IncA homolog fromE. coliis capable of inhibiting DNA replication inCaulobacter. We propose that IncA homologs serve a stress-dependent role in inhibiting DNA replication across diverse domains of life.
Audiovisual gamma stimulation enhances hippocampal neurogenesis and neural circuit plasticity in aging mice
Authors: Trinchero Mariela F. , Herrero Magalí , Mugnaini Matías , Aguilar-Arredondo Andrea , Benas Sabrina , Satorre Ignacio G. , Kropff Emilio , Schinder Alejandro F. 
Published: January 2025

AbstractGamma oscillations are disrupted in various neurological disorders, including Alzheimer’s disease (AD). In AD mouse models, non-invasive audiovisual stimulation (AuViS) at 40 Hz enhances gamma oscillations, clears amyloid-beta, and improves cognition. We investigated mechanisms of circuit remodeling underlying these restorative effects by leveraging the sensitivity of hippocampal neurogenesis to activity in middle-aged wild-type mice. AuViS increased progenitor cell proliferation, neuronal differentiation and morphological maturation of newborn granule cells, promoting their synaptic integration. While visual or auditory stimuli alone induced dendritic growth, axonal changes required combined audiovisual stimulation. The actions of AuViS involved neurotrophin pathways, as shown by the lack of effect upon TrkB signaling blockade. These results reveal widespread plasticity mechanisms triggered by AuViS, a therapeutic approach currently proposed for treating neurological disorders in humans.
Burnout among hospital doctors working at a West Midlands Major Trauma Centre: a cross-sectional study
Authors: Basso Alexandro , Attwater Amy 
Published: January 2025

AbstractIntroductionWorryingly, burnout is becoming increasingly common among the doctor cohort across the United Kingdom (UK) according to the General Medical Council (GMC), which has also seen an increasing desire to leave the UK profession. The main aims of this study were to: 1) determine the prevalence of burnout among doctors; 2) investigate the association between socio-demographic variables, including thoughts on leaving the profession or the NHS, and both burnout and its two dimensions; 3) examine the potentially predictive relationship between socio-demographic variables and burnout.MethodThis cross-sectional study employed the Oldenburg Burnout Inventory (OLBI) to determine the prevalence of burnout as measured across its two core dimensions, exhaustion and disengagement, among doctors working at University Hospital Coventry, a major trauma centre located within the West Midlands. In total, 156 doctors took part in a completed anonymised online questionnaire which also gathered socio-demographic information.Results111 (71%) participants were categorised as experiencing burnout, 22 (14%) and 7 (4%) were categorised as exhausted or disengaged, and 16 (10%) were categorised as non-burnout. Whilst there were no associations found between burnout group and socio-demographic variables, there were significant associations found between the exhaustion and disengagement scores and professional grade (p< 0.05 andp< 0.001, respectively). Doctors who were in the earlier stages of their career, particularly resident doctors in lower training, were found to have significantly higher exhaustion and disengagement scores, and this finding was supported by correlation analysis. There was significant association between burnout group and thoughts on leaving the profession or the NHS (p< 0.001). The predictive relationship between socio-demographic variables and burnout groups was found to be poor.ConclusionAt University Hospital Coventry, burnout is a persistent and prevalent issue that affects doctors across all societal and demographic groups. Given the current workforce crisis, more targeted interventions need to be done by organisations to minimise burnout across its two core dimensions to ensure current workforce trends are reversed.
Multiparticle collision framework for active polar fluids
Authors: Baziei Oleksandr , Loewe Benjamín , Shendruk Tyler N. 
Published: January 2025

Sufficiently dense intrinsically out-of-equilibrium suspensions, such as those observed in biological systems, can be modeled as active fluids characterized by their orientational symmetry. While mesoscale numerical approaches to active nematic fluids have been developed, polar fluids are simulated as either ensembles of microscopic self-propelled particles or continuous hydrodynamic-scale equations of motion. To better simulate active polar fluids in complex geometries or as a solvent for suspensions, mesoscale numerical approaches are needed. In this work, the coarse-graining multiparticle collision dynamics (MPCD) framework is applied to three active particle models to produce mesoscale simulations of polar active fluids. The first active-polar MPCD (AP-MPCD) is a variant of the Vicsek model, while the second and third variants allow the speed of the particles to relax towards a self-propulsion speed subject to Andersen and Langevin thermostats, respectively. Each of these AP-MPCD variants exhibits a flocking transition at a critical activity and banding in the vicinity of the transition point. We leverage the mesoscale nature of AP-MPCD to explore flocking in the presence of external fields, which destroys banding, and anisotropic obstacles, which act as a ratchet that biases the flocking direction. These results demonstrate the capacity of AP-MPCD to capture the known phenomenology of polar active suspensions and its versatility to study active polar fluids in complex scenarios.

Published by the American Physical Society
2025
Balancing innovation: the role of paradoxical leadership and ambidexterity in fostering team creativity
Authors: Khan Muhammad Tasnim , Ullah Sami 
Published: January 2025

Purpose
This study, grounded in ambidexterity theory, aims to investigate how paradoxical leadership (PXL) fosters team creativity in high-tech manufacturing companies, with team ambidexterity as a mediator and leader vision as a moderator. Given the fast-paced, innovation-driven demands of the high-tech sector, this research provides insights into how managers can effectively balance contradictory behaviors to drive team innovation.

Design/methodology/approach
Data was collected through a two-wave survey from team leaders and members across 169 teams in high-tech manufacturing companies. The time interval between data collection waves was two weeks. The data was aggregated at the team level using estimates for interrater reliability and interrater agreement. The structural equation modeling in R was used to test hypotheses.

Findings
The findings indicate that PXL positively impacts team creativity directly and through its influence on team ambidexterity. Team ambidexterity mediates the relationship between PXL and team creativity, while leader vision moderates the effects of PXL on team ambidexterity.

Practical implications
PXL benefits high-performance teams in technology sectors, such as software development, where rapid innovation and iterative processes are essential. In health care, PXL can optimize team dynamics, enabling medical research and patient care delivery breakthroughs. Regular training in ambidextrous thinking and feedback mechanisms makes this approach actionable for managers striving to cultivate creativity in high-stakes environments.

Originality/value
This study extends ambidexterity theory by linking PXL and team ambidexterity to team creativity. It provides high-tech manufacturing managers with concrete strategies to balance exploration and exploitation. These findings highlight actionable pathways for companies to sustain innovation in competitive, technology-driven industries.
Study on generation characteristics of a triboelectric ball bearing with defects
Authors: Wang Long , Wang Fengtao , Niu Linkai , Li Xin , Wang Zihao , Yan Shuping 
Published: January 2025

Purpose
The purpose of this paper is to combine triboelectric nanogeneration technology with ball bearing structure to achieve energy collection and fault monitoring.

Design/methodology/approach
In this paper, according to the rotation mode of ball bearings, the freestanding mode of triboelectric nanogeneration is selected to design and manufacture a novel triboelectric nanogeneration device Rolling Ball Triboelectric Nanogenerator (RB-TENG) which combines rotary energy collection with ball bearing fault self-sensing.

Findings
The 10,000s continuous operation experiment of the RB-TENG is carried out to verify its robustness. The accurate feedback relationship between the RB-TENG and rotation velocity can be demonstrated by the fitting comparison between the theoretical and experimental electrical signal periods at a certain time. By comparing the output electrical signals of the normal RB-TENG and the rotor spalling RB-TENG and polytetrafluoroethylene (PTFE) balls with different degrees of wear at 500 r/min, it can be concluded that the RB-TENG has an ideal monitoring effect on the radial clearance distance of bearings. The spalling fault test of the RB-TENG stator inner ring and rotor outer ring is carried out.

Originality/value
Through coupling experiments of rotor spalling fault of the RB-TENG and PTFE balls fault with different degrees of wear, it can be seen that when rotor spalling fault occurs, balls wear has a greater impact on the normal operation of the RB-TENG, and it is easier to identify. The fault self-sensing ability of the RB-TENG can be obtained, which is expected to provide an effective scheme for monitoring the radial wear clearance distance of ball bearings.

Peer review
The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-08-2024-0295/
Deep learning-based 6-DoF visual relocalization assisted simultaneous localization and mapping (SLAM)
Authors: Wang Shuo , Li Xin , Zhang Yu , Ma Songhui , Ren Xianrui 
Published: January 2025

Purpose
Visual simultaneous localization and mapping (SLAM) methods suffer from accumulated errors, especially in challenging environments without loop closure. By constructing lightweight offline maps and using deep learning (DL)-based technology in the two stages, i.e. image retrieval and feature matching, the goal is to reconstruct the six-degree-of-freedom (6-DoF) relationship between SLAM sequences and map sequences. This study aims to propose a comprehensive coarse-to-fine 6-DoF long-term visual relocalization assisted SLAM method specifically designed for challenging environments, aiming to achieve more accurate pose estimation.

Design/methodology/approach
First, image global feature matching and patch-level global feature matching are conducted to achieve optimal frame-to-frame matching. Second, a DL network is introduced to extract and match features between the most similar frames, enabling point-to-point motion estimation. Finally, a fast pose graph optimization method is proposed to achieve real-time optimization of the pose in the SLAM sequence.

Findings
The proposed method has been successfully validated on the real-world FinnForest Dataset and UZH-FPV Drone Racing Dataset. The accuracy of the proposed method is evaluated using absolute positional error and absolute rotational error. Experimental results show that in most cases, there are significant improvements in the root mean square error and the standard deviation of the error in pose estimation, and it performs better than loop closure in terms of accuracy. This indicates that the method has strong generalizability and robustness.

Originality/value
The main contribution of this study is the proposal of a complete DL-based coarse-to-fine 6-DoF long-term visual relocalization method to assist vSLAM, which demonstrates enhanced robustness and generalizability and can eliminate cumulative errors in pose estimation under challenging environments.
Impact of innovation effort on exports from emerging market firms: limitations arising from complementary resource constraints
Authors: Bose Udichibarna , Sengupta Abhijit 
Published: January 2025

Purpose
This paper aims to examine the impact of innovation effort on exports of resource constrained emerging market firms (EMFs) and boundary conditions imposed by complementary tangible and intangible resources on this relationship, using the lens of the knowledge-based view (KBV).

Design/methodology/approach
Analysis is based on annualized data from 19,057 Indian firms over the period of 2009–2017, controlling for endogeneity and selection bias (using Heckman correction), firm-level controls, year and sectoral fixed effects, within robust Tobit and ordinary least squares regressions. Export intensity and R&D intensity are the key dependent and independent variables, respectively.

Findings
The baseline impact of innovation effort on exports is found to be a concave inverted U-shape, exhibiting decreasing returns. Availability of complementary resources significantly impacts the nature of this relationship by weakening it for more resource-constrained firms. Faced with relatively greater scale-related constraints, the impact of innovation effort on exports disappears. Greater process-related constraints weaken the relationship as well.

Originality/value
Theoretically, these findings shed light on a nuanced relationship between a firm’s search for knowledge assets and access to foreign markets within resource constrained emerging market contexts. The limitations in the use and applicability of the KBV for EMFs’ internationalization success are highlighted, with suggested directions of future research.
Sharing economy as an alternative to fast fashion: a behavioral intention model
Authors: Ruiz-Navarro Ramon , Hintzmann Carolina , Corrons August 
Published: January 2025

Purpose
This study aims to investigate the factors influencing the adoption of sharing economy (SE) practices, specifically focusing on virtual clothing sharing platforms (VCSPs) as a sustainable alternative to fast fashion (FF). Given the negative environmental impact, labor exploitation and disposable culture associated with FF, this research aims to understand how economic, environmental and social motivations affect consumer behavioral intentions toward using VCSPs.

Design/methodology/approach
Data were collected through a survey of 392 participants from a global online academic institution operating across Europe, Asia, America and Africa. The sample included individuals from diverse professional, demographic and educational backgrounds, providing relevant context for studying VCSPs. The study uses the decomposed theory of planned behavior (DTPB) and structural equation modeling to analyze the data, focusing on how motivations and COVID-19 influence consumer engagement with VCSPs.

Findings
The results reveal that environmental and prosocial motivations are the primary determinants driving VCSPs adoption, followed by economic and social factors. The study also identifies a significant impact of COVID-19 on consumer intentions.

Originality/value
This research expands the literature on SE within the fashion sector by providing new insights into consumer behavior. The proposed model enhances the predictive power of DTPB by integrating additional variables, including trust, decomposing perceived utility into four dimensions, COVID-19 influence and new relationships, offering a more holistic view of the adoption process. The findings have significant implications for advancing sustainable fashion initiatives and offer viable alternatives to FF.
A self-powered wireless monitoring system driven by ambient RF energy for switch rails
Authors: Tian Song , Long Haitian , Li Yumei , Sun Yuhua , Wang Ping , Gao Mingyuan 
Published: January 2025

Purpose
This study aims to develop a novel self-powered monitoring system that uses radio frequency (RF) energy harvesting and ultra-low-power management technologies for real-time condition monitoring of switch rails.

Design/methodology/approach
The system is designed for integration within the jump wire holes of switch rails, ensuring structural integrity and aesthetic appeal. It features a highly efficient energy harvesting mechanism combined with optimized power management for wireless sensor nodes. An on-board antenna captures ambient RF energy, managed by high-efficiency circuits to ensure stable wireless sensor operation. An ultra-low-power system-on-chip is used to acquire and transmit multimodal data on vibration and temperature from the switch rails. The data collection is enhanced through a two-threshold approach, adapting to harvested energy levels for self-energy balancing.

Findings
Testing revealed that the energy harvesting subsystem operated stably at distances up to 2.9 m from the RF source, charging a 200 µF capacitor to 4.2 V in just 220 s. The monitoring subsystem’s average power consumption is in the low microwatt range. Continuous operation over 30 days in real conditions resulted in only a 5 mV reduction in battery voltage, indicating successful self-powered operation and validating long-term reliability in unattended scenarios.

Originality/value
This research presents an innovative solution, integrating RF energy harvesting with ultra-low-power technology, which addresses the power and stability challenges faced by traditional monitoring systems.
Preventing Infant Mortality Through Medicaid‐Administered Prenatal Care Coordination: Evidence From Wisconsin
Authors: Mallinson David C. , Nkhoma‐Mussa Yamikani B. , Gillespie Kate H. , Brown Roger L. 
Published: January 2025

ABSTRACTObjectiveTo estimate associations between Wisconsin Medicaid's Prenatal Care Coordination (PNCC) program and infant mortality.Data Sources and Study SettingWe analyzed birth records, Medicaid claims, and infant death records for all resident and in‐state Medicaid‐paid live deliveries during 2010–2018.Study DesignWe measured PNCC exposure during pregnancy dichotomously (none; any) and categorically (none; assessment/care plan only; service receipt). Our outcome was infant mortality (death at age < 365 days). Adjusted binary logit regressions and propensity score weighted regressions tested associations between PNCC receipt and infant mortality, and we estimated probabilities and average marginal effects of infant mortality. We also executed regressions with interactions on maternal race/ethnicity to determine if associations varied across Black non‐Hispanic (NH), Hispanic, and White NH births.Data Collection/Extraction MethodsOur sample consisted of 231,540 Medicaid‐paid births during 2010–2018. PNCC is only available to pregnant Medicaid beneficiaries.Principal FindingsInfant mortality was lower among PNCC assessment/care plan only births (5.0 deaths/1000 births) and PNCC service receipt births (6.1 deaths/1000 births) relative to non‐PNCC births (6.8 deaths/1000 births). This pattern was consistent in Black NH and Hispanic subgroups, but infant mortality did not vary by PNCC among White NH deliveries. Overall, adjusted binary logit regressions indicated that the probabilities of infant mortality were 0.70% for no PNCC and 0.53% for any PNCC, yielding an average marginal effect of −0.17 percentage points (95% confidence interval −0.22 percentage points, −0.11 percentage points). This association did not vary by PNCC exposure level. PNCC‐infant mortality associations were significantly stronger for Black NH births relative to White NH births. Results were consistent in propensity score weighted regressions.ConclusionsPNCC during pregnancy is associated with a lower probability of infant mortality, particularly in Black NH families. The benefit of PNCC on infant mortality may not depend on receiving services beyond care planning.