bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of fluvoxamine on preventing neuropsychiatric symptoms of post COVID syndrome in mild to moderate patients, a randomized placebo-controlled double-blind clinical trial
Authors: Farahani Ramin Hamidi , Ajam Ali , Naeini Alireza Ranjbar 
Published: March 2023

Abstract
Background
Shortly after the Coronavirus disease 2019 (COVID-19) pandemic, a considerable number of recovered patients reported persisting symptoms, especially neuropsychological manifestations, which were later named post-COVID syndrome (PCS). Immune dysregulation was suggested as one of the main mechanisms for PCS. Fluvoxamine, a selective serotonin reuptake inhibitor (SSRI) that is mostly used to treat depression, anxiety disorders, and obsessive–compulsive disorder, has been suggested as an anti-COVID drug due to its anti-inflammatory effects, mainly through the sigma-1 receptor. Therefore, we aimed to evaluate fluvoxamine's effect on PCS neuropsychiatric symptoms.

Method
In this double-blind randomized clinical trial, we included confirmed mild to moderate COVID-19 outpatients using polymerase chain reaction (PCR) by an infectious disease specialist. The presence of severe COVID-19 symptoms was evaluated by the infectious disease specialist and included dyspnea, SpO2 < 94% on room air, PaO2/FiO2 < 300 mm Hg, a respiratory rate > 30 breaths/min, and lung infiltrates > 50%. Then we performed permuted block randomization and assigned patients 1:1 into two groups to either receive fluvoxamine 100 mg tablet or a placebo daily for 10 days. Eligible patients were evaluated after 12 weeks for the presence of fatigue, as the primary, and other PCS symptoms as secondary outcomes.

Results
We screened a total of 486 patients from March to June 2022. After 12 weeks, 42 patients receiving fluvoxamine and 43 patients receiving Placebo were evaluated for PCS. Patients had a mean age of 38.5 ± 14.1 and 48% of them were women. Fatigue was significantly lower in the fluvoxamine group (p-value 0.026). No significant differences were observed in other symptoms.

Conclusion
We concluded that taking fluvoxamine during active COVID-19 can reduce the chance of fatigue but the advantage of fluvoxamine was not observed for other symptoms. Further studies are necessary to confirm these preliminary results.
An unusual form of kidney injury without glomerulonephritis in microscopic polyangiitis: a case report
Authors: Uysal Cihan , Yilmaz Tugba , Kocyigit Hafsa , Akgun Hulya , Sipahioglu Murat Hayri 
Published: March 2023

Abstract
Background
Microscopic polyangiitis (MPA), a kind of antineutrophil cytoplasmic autoantibody associated vasculitis (AAV), predominantly affects small-sized vessels. MPA is a significant cause of the pulmonary-renal syndrome. Pauci-immune necrotizing and crescentic glomerulonephritis is the typical renal histological feature of AAV. Tubulointerstitial lesions may occur and mostly form with inflammatory cell infiltration in the interstitium. However, a few cases reported only tubulointerstitial involvement without glomerular lesions in patients with MPA.

Case presentation
We present an MPA case, a 70-year-old male patient diagnosed with acute kidney injury accompanying the dialysis requirement. Only acute tubulointerstitial nephritis was revealed in kidney biopsy without evidence of glomerular injury. Also, interstitial pulmonary fibrosis was determined on computerized tomography, and myeloperoxidase antineutrophil cytoplasmic autoantibody was positive. Consequently, we have considered the main diagnosis as MPA. We did not prefer a standard tubulointerstitial nephritis treatment regimen due to the presence of life-threatening systemic vasculitis. Treatment was established like crescentic glomerulonephritis. Induction therapy consisted of pulse steroid, cyclophosphamide, and plasmapheresis. Unfortunately, severe SARS-CoV-2 infection caused death during induction therapy in this case.

Conclusions
The lack of glomerular injury and solely interstitial inflammation is atypical regarding AAV involvement in the kidney. This diversity might be initially considered as only a simple histological elaboration. However, it is a significant entity for guiding the treatment of AAV.
International rates of receipt of psychological therapy for psychosis and schizophrenia: systematic review and meta-analysis
Authors: Burgess-Barr Susanna , Nicholas Emily , Venus Bethany , Singh Niharika , Nethercott Abigail , Taylor Gemma , Jacobsen Pamela 
Published: March 2023

Abstract
Background
International clinical practice guidelines commonly recommend the provision of psychological therapies for psychosis and schizophrenia as an adjunct to medication. However, access to recommended therapies in routine clinical practice is limited. The aim of this review was to synthesise the available data on the provision of recommended psychological therapies for psychosis and schizophrenia across international mental health systems.

Methods
Electronic databases (PsychINFO, Pubmed and EMBASE) were searched for audits, service evaluation projects, or surveys, which reported data on rates of offer or receipt of any recommended psychological therapy or therapeutic intervention as part of routine clinical care.

Results
Twenty-two eligible studies from 9 countries were identified (N participants = 79,407). The most commonly recommended therapies in national guidelines were Cognitive-Behavioural Therapy for Psychosis (CBTp) and Family Interventions (FI). The overall pooled prevalence of rate of receipt of CBTp was 24% [95% CI 0.15–0.32] based on 15 studies (N = 42,494), with a higher rate of receipt of therapy found when pooling data from Early Intervention services only (41% [95% CI 0.21–0.60], 6 studies, N = 11,068). The overall pooled prevalence of rate of receipt of FI was 30% [95% CI 0.22–0.37] based on 14 studies (N = 13,863).

Conclusions
Overall rates of receipt of recommended psychological therapies for psychosis were low across the 9 countries data were available for in this review. However, there were high rates of heterogeneity across studies, meaning that pooled estimates should be interpreted with caution. Sources of heterogeneity included different service settings (e.g. early intervention vs. non-early intervention services), and varying methods used to collect the data (e.g. audit of electronic health records vs. self-report etc.). There were no available data from the continents of South America, Asia, or Africa, meaning that a truly global picture of provision of psychological therapies for psychosis and schizophrenia is currently lacking.
Diet prevents the expansion of segmented filamentous bacteria and ileo-colonic inflammation in a model of Crohn’s disease
Authors: Metwaly Amira , Jovic Jelena , Waldschmitt Nadine , Khaloian Sevana , Heimes Helena , Häcker Deborah , Ahmed Mohamed , Hammoudi Nassim , Le Bourhis Lionel , Mayorgas Aida , Siebert Kolja , Basic Marijana , Schwerd Tobias , Allez Matthieu , Panes Julian , Salas Azucena , Bleich André , Zeissig Sebastian , Schnupf Pamela , Cominelli Fabio , Haller Dirk 
Published: March 2023

Abstract
Background
Crohn’s disease (CD) is associated with changes in the microbiota, and murine models of CD-like ileo-colonic inflammation depend on the presence of microbial triggers. Increased abundance of unknown Clostridiales and the microscopic detection of filamentous structures close to the epithelium of TnfΔARE mice, a mouse model of CD-like ileitis pointed towards segmented filamentous bacteria (SFB), a commensal mucosal adherent bacterium involved in ileal inflammation.

Results
We show that the abundance of SFB strongly correlates with the severity of CD-like ileal inflammation in two mouse models of ileal inflammation, including TnfΔARE and SAMP/Yit mice. SFB mono-colonization of germ-free TnfΔARE mice confirmed the causal link and resulted in severe ileo-colonic inflammation, characterized by elevated tissue levels of Tnf and Il-17A, neutrophil infiltration and loss of Paneth and goblet cell function. Co-colonization of SFB in human-microbiota associated TnfΔARE mice confirmed that SFB presence is indispensable for disease development. Screening of 468 ileal and colonic mucosal biopsies from adult and pediatric IBD patients, using previously published and newly designed human SFB-specific primer sets, showed no presence of SFB in human tissue samples, suggesting a species-specific functionality of the pathobiont. Simulating the human relevant therapeutic effect of exclusive enteral nutrition (EEN), EEN-like purified diet antagonized SFB colonization and prevented disease development in TnfΔARE mice, providing functional evidence for the protective mechanism of diet in modulating microbiota-dependent inflammation in IBD.

Conclusions
We identified a novel pathogenic role of SFB in driving severe CD-like ileo-colonic inflammation characterized by loss of Paneth and goblet cell functions in TnfΔARE mice. A purified diet antagonized SFB colonization and prevented disease development in TnfΔARE mice in contrast to a fiber-containing chow diet, clearly demonstrating the important role of diet in modulating a novel IBD-relevant pathobiont and supporting a direct link between diet and microbial communities in mediating protective functions.
Noisy pursuit by a self-steering active particle in confinement
(a)
Authors: Gassner Marielle , Goh Segun , Gompper Gerhard , Winkler Roland G. 
Published: March 2023

Abstract
The properties of a cognitive, self-propelled, and self-steering particle in the presence of a stationary target are analyzed theoretically and by simulations. In particular, the effects of confinement in competition with activity and steering are addressed. The pursuer is described as an intelligent active Ornstein-Uhlenbeck particle (iAOUP), confined in a harmonic potential. For the free pursuer, we find universal scaling regimes for the pursuer-target distance in terms of the Péclet number and maneuverability. Steering results in a novel constant mean-distance regime, which broadens with increasing maneuverability. Confinement strongly affects the propulsion direction and leads to a scaling at large Péclet numbers similar to that in the absence of confinement, yet with a pronounced dependence on confinement strength.
Molecular Genetics of Diffuse Sclerosing Papillary Thyroid Cancer
Authors: Alswailem Meshael , Alghamdi Balgees , Alotaibi Anwar , Aljomiah Abeer , Al-Hindi Hindi , Murugan Avaniyapuram Kannan , Abouelhoda Mohamed , Shi Yufei , Alzahrani Ali S 
Published: March 2023

Abstract

Context
Diffuse sclerosing papillary thyroid cancer (DSPTC) is rare, with limited data on its molecular genetics.

Objective
We studied the molecular genetics of a cohort of DSPTC.

Methods
DNA was isolated from paraffin blocks of 22 patients with DSPTC (15 females, 7 males, median age 18 years, range 8-81). We performed polymerase chain reaction–based Sanger sequencing and a next-generation sequencing (NGS) gene panel to characterize the genomic landscape of these tumors. We classified genetic alterations to definitely or probably pathogenic. Definitely pathogenic are genetic alterations that are well known to be associated with PTC (e.g., BRAFV600E). Probably pathogenic are other alterations in genes that were reported in The Cancer Genome Atlas or the poorly differentiated and anaplastic thyroid cancer datasets.

Results
Three tumors were tested only by Sanger sequencing and were negative for BRAFV600E, HRAS, KRAS, NRAS, TERT promoter, PTEN, and PIK3CA mutations. The other 19 tumors tested by NGS showed definitely pathogenic alterations in 10 patients (52.6%): 2/19 (10.5%) BRAFV600E, 5/19 (26.3%) CCDC6-RET (RET/PTC1), 1/19 (5.3%) NCOA4-RET (RET/PTC3), 1/19 (5.3%) STRN-ALK fusion, and 2/19 (10.6%) TP53 mutations. Probably pathogenic alterations occurred in 13/19 tumors (68.4%) and included variants in POLE (31.6%), CDKN2A (26%), NF1 (21%), BRCA2 (15.8%), SETD2 (5.3%), ATM (5.3%), FLT3 (5.3%), and ROS1 (5.3%). In 1 patient, the gene panel showed no alterations. No mutations were found in the RAS, PTEN, PIK3CA, or TERT promoter in all patients. There was no clear genotype/phenotype correlation.

Conclusion
In DSPTC, fusion genes are common, BRAFV600E is rare, and other usual point mutations are absent. Pathogenic and likely pathogenic variants in POLE, NF1, CDKN2A, BRCA2, TP53, SETD2, ATM, FLT3, and ROS1 occur in about two-thirds of DTPTC.
Biochemical Assessment of Pheochromocytoma and Paraganglioma
Authors: Eisenhofer Graeme , Pamporaki Christina , Lenders Jacques W M 
Published: March 2023

AbstractPheochromocytoma and paraganglioma (PPGL) require prompt consideration and efficient diagnosis and treatment to minimize associated morbidity and mortality. Once considered, appropriate biochemical testing is key to diagnosis. Advances in understanding catecholamine metabolism have clarified why measurements of the O-methylated catecholamine metabolites rather than the catecholamines themselves are important for effective diagnosis. These metabolites, normetanephrine and metanephrine, produced respectively from norepinephrine and epinephrine, can be measured in plasma or urine, with choice according to available methods or presentation of patients. For patients with signs and symptoms of catecholamine excess, either test will invariably establish the diagnosis, whereas the plasma test provides higher sensitivity than urinary metanephrines for patients screened due to an incidentaloma or genetic predisposition, particularly for small tumors or in patients with an asymptomatic presentation. Additional measurements of plasma methoxytyramine can be important for some tumors, such as paragangliomas, and for surveillance of patients at risk of metastatic disease. Avoidance of false-positive test results is best achieved by plasma measurements with appropriate reference intervals and preanalytical precautions, including sampling blood in the fully supine position. Follow-up of positive results, including optimization of preanalytics for repeat tests or whether to proceed directly to anatomic imaging or confirmatory clonidine tests, depends on the test results, which can also suggest likely size, adrenal vs extra-adrenal location, underlying biology, or even metastatic involvement of a suspected tumor. Modern biochemical testing now makes diagnosis of PPGL relatively simple. Integration of artificial intelligence into the process should make it possible to fine-tune these advances.
Test–retest, inter- and intra-rater reproducibility of size measurements of focal bone marrow lesions in MRI in patients with multiple myeloma
Authors: Wennmann Markus , Grözinger Martin , Weru Vivienn , Hielscher Thomas , Rotkopf Lukas Thomas , Bauer Fabian , Gnirs Regula , Nonnenmacher Tobias , Sauer Sandra , Goldschmidt Hartmut , Weinhold Niels , Bonekamp David , Weber Tim Frederik , Schlemmer Heinz-Peter , Delorme Stefan 
Published: March 2023

Objective:
To investigate the reproducibility of size measurements of focal bone marrow lesions (FL) in MRI in patients with monoclonal plasma cell disorders under variation of patient positioning and observer.

Methods:
A data set from a prospective test–retest study was used, in which 37 patients with a total of 140 FL had undergone 2 MRI scans with identical parameters after patient repositioning. Two readers measured long and short axis diameter on the initial scan in T 1 weighted, T 2 weighted short tau inversion recovery and diffusion-weighted imaging sequences. The first reader additionally measured FL on the retest-scan. The Bland–Altman method was used to assess limits of agreement (LoA), and the frequencies of absolute size changes were calculated.

Results:
In the simple test–retest experiment with one identical reader, a deviation of ≥1 mm / ≥2 mm / ≥3 mm for the long axis diameter in T 1 weighted images was observed in 66% / 25% / 8% of cases. When comparing measurements of one reader on the first scan to the measurement of the other reader on the retest scan, a change of ≥1 mm / ≥3 mm / ≥5 mm for the long axis diameter in T 1 weighted images was observed in 78% / 21% / 5% of cases.

Conclusion:
Small deviations in FL size are common and probably due to variation in patient positioning or inter-rater variability alone, without any actual biological change of the FL. Knowledge of the uncertainty associated with size measurements of FLs is critical for radiologists and oncologists when interpreting changes in FL size in clinical practice and in clinical trials.

Advances in knowledge:
According to the MY-RADs criteria, size measurements of focal lesions in MRI are now of relevance for response assessment in patients with monoclonal plasma cell disorders.
Size changes of 1 or 2 mm are frequently observed due to uncertainty of the measurement only, while the actual focal lesion has not undergone any biological change.
Size changes of at least 6 mm or more in T 1 weighted or T 2 weighted short tau inversion recovery sequences occur in only 5% or less of cases when the focal lesion has not undergone any biological change.
Early assessment and intervention by a dedicated health and social care professional team in the emergency department in older adults compared to treatment-as-usual: Health Economic Analysis Plan for within-trial cost effectiveness analysis
Authors: Corcoran Cian , Ruiz-Adame Manuel , Trépel Dominic 
Published: March 2023

Background: Older adults (aged over 65 years) experience high rates of adverse outcomes after presenting to emergency departments (EDs). The OPTI-MEND trial aimed to examine what impact intervention and early assessment by a dedicated health and social care professional (HSCP) team can have on quality of care for older adults in EDs. This paper presents the finalized Health Economic Analysis Plan (HEAP) specifying how the within-trial cost effectiveness analysis (CEA) will be conducted. Methods: This HEAP was developed retrospectively in collaboration with the OPTI-MEND team and the trial health economist to provide a plan to conduct the CEA. The HEAP aimed to fulfil international recommendations from a consensus of the required items for inclusion in HEAPs. In line with best practice guidelines, and to ensure full visibility in the scientific process, this paper makes the HEAP available in the public domain. Results: This HEAP illustrates the plan we followed when conducting our CEA. As this paper is a protocol it has no concrete results. A detailed list of all items in the HEAP are provided as Extended data on Open Science Framework at https://doi.org/10.17605/OSF.IO/YVG2P. Conclusions: Cost effectiveness analysis is an opportunity to extend beyond the primary clinical analysis of a trial. Congruent to a trial’s statistical analysis plan (SAP), a HEAP outlines the plan for estimating cost effectiveness and avoiding potentially spurious post-hoc analysis and questionable policy recommendations.
Phase relations in heat treated sodium borosilicate glasses
Authors:   TU Bergakademie Freiberg, Sander S. A. H. , Syrowatka F. ,   Martin-Luther-University Halle-Wittenberg, Enke D. ,   University of Leipzig, Roggendorf H. 
Published: March 2023

Sodium borosilicate glasses are processed to porous glasses as well as to Vycor™ type glasses via phase separation and selective leaching. Both materials consist mainly of SiO2. Thermal treatment inducing phase separation is crucial for microstructure development. Sodium borosilicate glasses with molar compositions of 8Na2O.21B2O3.71SiO2 and 8Na2O.28B2O3.64 SiO2 were melted, rapidly cooled and investigated by thermal analysis and scanning electron microscopy. The glasses were thermally treated for 120 h at 630 to 730°C, and then leached, first for 72 h in 0·1 M HCl at 60°C, and subsequently for 4 h in 0·5 M NaOH at 30°C. X-ray fluorescence was applied to characterise the chemical compositions. Microstructure development was first analysed by differential thermal analysis and dilatometry, and the pore structure was characterised by Hg porosimetry and N2 adsorption. Heat treated glasses were then analysed by low voltage scanning electron microscopy, combined in one case with chemical analysis by energy dispersive x-ray analysis. The results are discussed with respect to phase relations. After long term heat treatment, at least three phases exist in two independent metastable two-phase equilibria on different size and time scales.
100  Gbps quantum-secured and O-RAN-enabled programmable optical transport network for 5G fronthaul
Authors: Arabul Ekin , Oliveira Romerson D. , Emami Amin , Typos Stavros , Vrontos Constantinos , Wang Rui , Nejabati Reza , Simeonidou Dimitra 
Published: March 2023

We have successfully demonstrated the first 5G open radio access network (O-RAN)-enabled and quantum-secured optical network solution and tested its performance in a 5G fronthaul use case. Our proposed solution is unique in a way that it combines a quantum key distribution (QKD)-compatible on-demand programmable 100 Gbps Ethernet encryptor with multi-tenant network operation while satisfying the stringent timing requirements of the 5G O-RAN with ultra-low pipeline latency. Moreover, our encryption cores provide the fastest reconfiguration speeds with the highest transmission capacity. By using dynamic reconfiguration technology, encryption schemes can be switched between Advanced Encryption Standard (AES) variations AES-256, AES-192, and AES-128 and Camellia-256, XOR, or no-encryption configurations in 16.7 ms for encryption and 24.1 ms for decryption. Furthermore, the key slicing functionality was introduced to our system, allowing users to have their separate key storages within the field programmable gate array and different key exchange schemes or refresh rates per client, where a secret key rate of 1.6 keys/s per client for less than 10 Gb of encrypted data could be provided. With encryption, the lowest system latency of 817.6 ns was achieved. Without encryption, the system latency could be as low as 667.2 ns. When our proposed system was tested in 5G fronthaul where our design was placed between a 5G radio unit and a 5G distributed unit/central unit, and the traffic between the 5G customer premises equipment and 5G core user plane function was transported and encrypted by our system over 100 Gbps, no significant impact on network latency on the millisecond scale was observed. Our system’s 10 Gbps fronthaul interface was stressed with a large Ethernet frame (1500B) at a rate of ≈9.8Gbps with 300,000 Internet Control Message Protocol pings, and less than 1% data loss was observed.