bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microstructure evolution and strain hardening behavior of thermomechanically processed low-C high-manganese steels: an effect of deformation temperature
Authors: Kozłowska Aleksandra , Stawarczyk Piotr , Grajcar Adam , Radwański Krzysztof , Matus Krzysztof , Samek Ludovic 
Published: June 2023

Abstract
Effects of reduced (– 40 °C), ambient (20 °C), and elevated (200 °C) deformation temperatures on the microstructure evolution and strain hardening behavior of two low-C thermomechanically processed high-manganese steels were studied. The microstructure was characterized by means of scanning electron microscopy (SEM), electron backscatter diffraction (EBSD), and transmission electron microscopy (TEM) techniques. The temperature-dependent tendency of austenite to strain-induced ε/α′-martensitic transformation and mechanical twinning was qualitatively and quantitatively assessed using the EBSD technique. The steel containing 26 wt% of Mn showed the beneficial strength–ductility balance at reduced deformation temperature -40 °C due to the intense Transformation-Induced Plasticity (TRIP) effect which resulted in the formation of significant ε- and α′-martensite fractions during tensile deformation. The mechanical properties of steel containing 27 wt% of Mn were more beneficial at elevated deformation temperature 200 °C due to the occurrence of intense Twinning-Induced Plasticity (TWIP) effect expressed by the presence of significant fraction of mechanical twins. Moreover, at the highest deformation temperature 200 °C, the evidence of thermally activated processes affecting the mechanical behavior of the higher Mn steel was identified and described.
Algorithmic Credit Scoring in Vietnam: A Legal Proposal for Maximizing Benefits and Minimizing Risks
Authors: Lainez Nicolas , Gardner Jodi 
Published: June 2023

AbstractArtificial intelligence (AI) and big data are transforming the credit market around the world. Algorithmic credit scoring (ACS) is increasingly used to assess borrowers’ creditworthiness, using technology to glean non-traditional data from smartphones and analyze them through machine-learning algorithms. These processes promise efficiency, accuracy, and cost-effectiveness compared with traditional credit scoring. However, this technology raises public concerns about opacity, unfair discrimination, and threats to individual privacy and autonomy. Many countries in Southeast Asia are introducing ACS in consumer finance markets, although—even with the significant concerns raised—there is an ongoing and concerning lag in oversight and regulation of the process. Regulation is vital to delivering big data and AI promises in the financial services market, while ensuring fairness and public interest. This article utilizes Vietnam, where the lending industry deploys ACS but in a situation of legal limbo, as a case-study to analyze the consequences of this technology. Vietnam is one of the foremost Southeast Asian countries in which ACS usage is spreading rapidly, and this provides an excellent opportunity to review the regulation, or lack thereof, and determine the implications that this may have for other countries that are currently introducing ACS in consumer finance markets. The article concludes with a proposal to regulate ACS in Vietnam based on international regulation and guidelines on ACS, data privacy, and AI to enable a transparent, accessible, and fair process.
Quantifying the Implementation and Cost of a Multisite Antibiotic Stewardship Intervention for Asymptomatic Bacteriuria
Authors: Amenta Eva , Grigoryan Larissa , Rajan Suja S. , Ramsey David , Kramer Jennifer R. , Walder Annette , Chou Andrew , Van John N. , Krein Sarah L. , Hysong Sylvia , Naik Aanand D. , Trautner Barbara W. 
Published: June 2023

Abstract

Objective:
The intensity of an antibiotic stewardship intervention to achieve clinical impact is not known. We conducted a multisite dissemination project of an intervention to reduce treatment of asymptomatic bacteriuria (ASB) and studied: (1) the association between implementation metrics and clinical outcomes and (2) the cost of implementation.

Design/Setting/Participants:
A central site facilitated a multimodality intervention to decrease unnecessary urine cultures and antibiotic treatment in patients with ASB at 4 Veterans Affairs medical centers.

Methods:
The intervention consisted of a decision support aid algorithm and interactive teaching cases that provided in the moment audit and feedback on how to manage ASB. Implementation outcomes included minutes spent in intervention delivery, number of healthcare professionals reached, and number of sessions delivered. Clinical outcomes included days of antibiotic therapy (DOT), length of antibiotic therapy (LOT), and number of urine cultures ordered per 1000 bed days. Personnel reported weekly time logs.

Results:
Minutes spent in intervention delivery were inversely correlated with two clinical outcomes, DOT (R −0.3, P = .04) and LOT (R −0.3, P = .02). Number of healthcare professionals reached and number of sessions delivered were not correlated with clinical outcomes of DOT (R –0.003, P = .98, R = −0.059, P = .69) or LOT (R +0.073, P = .62, R −0.102, P = .49). Physician champions spent an average of 3.8% of effort on the intervention. The implementation cost was USD 22,299/year per site on average.

Conclusions:
The amount of time local teams spent in delivery of an antibiotic stewardship intervention was correlated with the desired decrease in antibiotic use. Implementing this successful antibiotic stewardship intervention required minimal time.
Management of depression in people living with HIV/AIDS in Senegal: Acceptability, feasibility and benefits of group interpersonal therapy
Authors: Bernard Charlotte , Font Hélène , Ziadeh Salaheddine , Tine Judicaël M. , Diaw Abibatou , Ndiaye Ibrahima , Samba Oumar , Bottai Thierry , Jacquesy Laurent , Verdeli Helena , Ngom Ndeye F. , Dabis François , Seydi Moussa , de Rekeneire Nathalie ,   The IeDEA West Africa Cohort Collaboration
Published: June 2023

Abstract
Depression is highly prevalent in people living with HIV (PLWH) and has negative consequences for daily life and care. We evaluated for the first time the acceptability, feasibility and benefits of group interpersonal therapy (IPT), combined with a task-shifting approach, to treat depression in PLWH in Senegal. PLWH with depression received group IPT following the World Health Organization protocol. Acceptability and feasibility criteria were defined from the literature data. The PHQ-9, the WHODAS, and the 12-item-stigma scale were used, pre- and post-treatment, including a 3-month follow-up, to assess depressive symptom severity, functioning and stigma, respectively. General linear mixed models were used to describe changes in outcomes over time. Of 69 participants, 60 completed group IPT. Refusal to enroll and dropout rates were 6.6 and 12.7%, respectively. Ninety-seven percent of participants attended at least seven out of eight sessions. Patients and facilitators endorsed group IPT, with willingness to recommend it. Depressive symptoms and disability improved drastically and sustainably. We showed that group IPT is well accepted and feasible in Senegal as treatment for depression in PLWH. Combined with a task-shifting approach, it can narrow the gap in mental health treatment. Implementation may be enhanced by refining patient identification procedures and increasing treatment accessibility.
Socioeconomic disparities in the prevalence of multidrug resistance in Enterobacterales
Authors: Brown Dylan R. , Henderson Heather I. , Ruegsegger Laura , Moody James , van Duin David 
Published: June 2023

AbstractWe examined the association between multidrug resistance and socioeconomic status (SES), analyzing microbiological and ZIP-code–level socioeconomic data. Using generalized linear models, we determined that multidrug resistance is significantly and persistently more prevalent in samples taken from patients residing in low-income ZIP codes versus high-income ZIP codes in North Carolina.
Trivial source character tables of , part II
Authors: Farrell Niamh , Lassueur Caroline 
Published: June 2023

AbstractWe compute the trivial source character tables (also called species tables of the trivial source ring) of the infinite family of finite groups $\operatorname{SL}_{2}(q)$ for q even over a large enough field of odd characteristics. This article is a continuation of our article Trivial Source Character Tables of$\operatorname{SL}_{2}(q)$, where we considered, in particular, the case in which q is odd in non-defining characteristic.
Investigation of cardiovascular risk parameters in adolescents with metabolic syndrome
Authors: Can Ummugulsum , Akdu Sadinaz , Bağcı Zafer , Buyukinan Muammer 
Published: June 2023

AbstractBackground:Metabolic syndrome leading to type 2 diabetes mellitus and cardiovascular diseases is a chronic multifactorial syndrome, associated with low-grade inflammation status. In our study, we aimed at assessing the serum levels of follistatin (FST), pregnancy-associated plasma protein-A (PAPP-A), and platelet/endothelial cell adhesion molecule-1 (PECAM-1) in adolescent patients with metabolic syndrome.Methods:This study was performed in 43 (19 males, 24 females) metabolic syndrome adolescents and 37 lean controls matched for age and sex. The serum levels of FST, PECAM-1, and PAPP-A were measured by using ELISA method.Results:Serum FST and PAPP-A levels in metabolic syndrome were significantly higher than those of controls (p < 0.005 and p < 0.05). However, there was no difference in serum PECAM-1 levels between metabolic syndrome and control groups (p = 0.927). There was a significant positive correlation between serum FST and triglyceride (r = 0.252; p < 0.05), and PAPP-A and weight, (r = 0.252; p < 0.05) in metabolic syndrome groups. Follistatin was determined statistically significant in both univariate (p = 0,008) and multivariate (p = 0,011) logistic regression analysis.Conclusions:Our findings indicated a significant relationship between FST and PAPP-A levels and metabolic syndrome. These findings offer the possibility of using these markers in diagnosis of metabolic syndrome in adolescents as the prevention of the future complications.
Sex significantly predicts medial temporal volume when controlling for the influence of ApoE4 biomarker and demographic variables: A cross-ethnic comparison
Authors: Garcia Patricia , Mendoza Lisandra , Padron Dilianna , Duarte Andres , Duara Ranjan , Loewenstein David , Greig-Custo Maria , Barker Warren , Curiel Rosie , Rosselli Monica , Rodriguez Miriam 
Published: June 2023

AbstractObjective:To explore the relationship between age, education, sex, and ApoE4 (+) status to brain volume among a cohort with amnestic mild cognitive impairment (aMCI).Method:One hundred and twenty-three participants were stratified into Hispanic (n = 75) and White non-Hispanic (WNH, N = 48). Multiple linear regression analyses were conducted with age, education, sex, and ApoE4 status as predictor variables and left and right combined MRI volumes of the hippocampus, parahippocampus, and entorhinal cortex as dependent variables. Variations in head sizes were corrected by normalization with a total intracranial volume measurement.Results:Bonferroni-corrected results indicated that when controlling for ApoE4 status, education, and age, sex was a significant predictor of hippocampal volume among the Hispanic group (β = .000464, R2 = .196, p < .01) and the WNH group (β = .000455, R2 = .195, p < .05). Education (β = .000028, R2 = .168, p < .01) and sex (β = .000261, R2 = .168, p < .01) were significant predictors of parahippocampal volume among the Hispanic MCI group when controlling for the effects of ApoE4 status and age. One-way ANCOVAs comparing hippocampal and parahippocampal volume between males and females within groups revealed that females had significantly larger hippocampal volumes (p < .05). Hispanic females had significantly larger hippocampal (p < .001) and parahippocampal (p < .05) volume compared to males. No sex differences in parahippocampal volume were noted among WNHs.Conclusions:Biological sex, rather than ApoE4 status, was a greater predictor of hippocampal volume among Hispanic and WNH females. These findings add to the mixed literature on sex differences in dementia research and highlight continued emphasis on ethnic populations to elucidate on neurodegenerative disparities.
Israel: a novel wedge issue in Canadian electoral politics
Authors: Dufresne Yannick , Levin Jamie , Paquin Jonathan , Rancourt Marc-Antoine 
Published: June 2023

AbstractThis article investigates the relationship between partisan foreign policy positions on Israel and the voting behavior of religious minorities in Canada. It discusses Stephen Harper's strong pro-Israeli stance in foreign policy when the Conservatives were in power and focuses on two main explanations accounting for such politicization of Israel, namely moral obligations and political clientelism. These hypotheses are tested using the 1968–2015 Canadian Election Study (CES) surveys and the 2011–2015 Vox Pop Labs election data. The results suggest that the Israeli issue had an impact on the support for the Conservatives among voters from religious minorities. Considering the effect of this foreign policy positions, Jewish Canadians are shown to be more supportive of the Conservatives, while the opposite pattern is observed among Muslim Canadians. The implications of these findings are then discussed.
Operational AOD Retrieval at Subkilometer Resolution Using OceanSat‐2 OCM Over Land: SAER Algorithm, Uncertainties, Validation & Inter‐Sensor Comparison
Authors: Mishra Manoj K. , Misra Arundhati , Kumar Raj 
Published: June 2023

AbstractThe ocean color monitor (OCM) sensor onboard OceanSat‐2 is providing data in visible and near Infrared (NIR) bands. Due to the limited spectral coverage of OCM, the widely used dark‐target and deep‐blue aerosol algorithms cannot be adapted. Here, a new aerosol optical depth (AOD) retrieval algorithm for OCM (or similar sensors) over land, termed Space Applications Center AErosol Retrieval (SAER) is described. It utilizes two blue bands for the AOD inversion and, Red and NIR band to characterize the surface in visible bands without assuming red and NIR bands transparent to aerosols. Unlike the dark‐target algorithm, the SAER algorithm can retrieve AOD over bright arid and urban areas too. The uncertainty analysis of SAER suggests a theoretically expected error (EE) envelope of ±(0.06 + 0.26 × AOD) for typical retrieval conditions. OCM AOD over land is retrieved operationally for the first time over Indian and neighboring countries' landmass at the finest spatial resolution of 0.007°. The SAER algorithm is validated against in‐situ AOD measurements during the years 2016–2018 at 21 Aerosol Robotic Network stations located in south‐Asia. Overall validation using 1900 match‐up points shows correlations exceeding 0.8 with 74% of retrievals within EE. The retrievals over cropland, grassland, and mixed land cover types show high (low) correlation (bias), while over bright urban areas somewhat low (high) correlation (bias) is observed. Excluding monsoon season, OCM AOD retrievals show good performance over the year. The performance of MODerate Resolution Imaging Spectroradiometer dark‐target and OCM AOD, against common in‐situ, is close to each other. The study shows that OCM AOD can be used for air quality monitoring/modeling at high spatial resolution.
Statistical Decomposition and Machine Learning to Clean In Situ Spaceflight Magnetic Field Measurements
Authors: Finley M. G. , Bowen T. A. , Pulupa M. , Koval A. , Miles D. M. 
Published: June 2023

AbstractRobust in situ magnetic field measurements are critical to understanding the various mechanisms that couple mass, momentum, and energy throughout our solar system. However, the spacecraft on which magnetometers are often deployed contaminate the magnetic field measurements via onboard subsystems including reaction wheels and magnetorquers. Two magnetometers can be deployed at different distances from the spacecraft to determine an approximation of the interfering field for subsequent removal, but constant data streams from both magnetometers can be impractical due to power and telemetry limitations. Here we propose a method to identify and remove time‐varying magnetic interference from sources such as reaction wheels using statistical decomposition and convolutional neural networks, providing high‐fidelity magnetic field data even in cases where dual‐sensor measurements are not constantly available. For example, a measurement interval from the Parker Solar Probe outboard magnetometer experienced a 95.1% reduction in reaction wheel interference following application of the proposed technique.
Efficacy, safety and pharmacokinetics of Unecritinib (TQ-B3101) for patients with ROS1 positive advanced non-small cell lung cancer: a Phase I/II Trial
Authors: Lu Shun , Pan Hongming , Wu Lin , Yao Yu , He Jianxing , Wang Yan , Wang Xiuwen , Fang Yong , Zhou Zhen , Wang Xicheng , Cai Xiuyu , Yu Yan , Ma Zhiyong , Min Xuhong , Yang Zhixiong , Cao Lejie , Yang Huaping , Shu Yongqian , Zhuang Wu , Cang Shundong , Fang Jian , Li Kai , Yu Zhuang , Cui Jiuwei , Zhang Yang , Li Man , Wen Xinxuan , Zhang Jie , Li Weidong , Shi Jianhua , Xu Xingxiang , Zhong Diansheng , Wang Tao , Zhu Jiajia 
Published: June 2023

AbstractThis phase I/II trial characterized the tolerability, safety, and antitumor activities of unecritinib, a novel derivative of crizotinib and a multi-tyrosine kinase inhibitor targeting ROS1, ALK, and c-MET, in advanced tumors and ROS1 inhibitor-naive advanced or metastatic non-small cell lung cancer (NSCLC) harboring ROS1 rearrangements. Eligible patients received unecritinib 100, 200, and 300 mg QD, and 200, 250, 300, and 350 mg BID in a 3 + 3 design during dose escalation and 300 and 350 mg BID during expansion. Phase II trial patients received unecritinib 300 mg BID in continuous 28-day cycles until disease progression or unacceptable toxicity. The primary endpoint was the objective response rate (ORR) per independent review committee (IRC). Key secondary endpoints included intracranial ORR and safety. The ORR of 36 efficacy evaluable patients in the phase I trial was 63.9% (95% CI 46.2%, 79.2%). In the phase II trial, 111 eligible patients in the main study cohort received unecritinib. The ORR per IRC was 80.2% (95% CI 71.5%, 87.1%) and the median progression-free survival (PFS) per IRC was 16.5 months (95% CI 10.2, 27.0). Additionally, 46.9% of the patients who received recommended phase II dose of 300 mg BID experienced grade 3 or higher treatment-related adverse events. Treatment-related ocular disorders and neurotoxicity occurred in 28.1% and 34.4% of patients, respectively, but none was grade 3 or higher. Unecritinib is efficacious and safe for ROS1 inhibitor-naive patients with ROS1-positive advanced NSCLC, particularly patients with brain metastases at baseline, strongly supporting that unecritinib should become one of the standards of care for ROS1-positive NSCLC.ClinicalTrials.gov identifier: NCT03019276 and NCT03972189.
MiR-146a-5p deficiency in extracellular vesicles of glioma-associated macrophages promotes epithelial-mesenchymal transition through the NF-κB signaling pathway
Authors: Xu Chao , Wang Pan , Guo Haiyan , Shao Chuan , Liao Bin , Gong Sheng , Zhou Yanghao , Yang Bingjie , Jiang Haotian , Zhang Gang , Wu Nan 
Published: June 2023

AbstractGlioma-associated macrophages (GAMs) are pivotal chains in the tumor immune microenvironment (TIME). GAMs mostly display M2-like phenotypes with anti-inflammatory features related to the malignancy and progression of cancers. Extracellular vesicles derived from immunosuppressive GAMs (M2-EVs), the essential components of the TIME, greatly impact the malignant behavior of GBM cells. M1- or M2-EVs were isolated in vitro, and human GBM cell invasion and migration were reinforced under M2-EV treatment. Signatures of the epithelial-mesenchymal transition (EMT) were also enhanced by M2-EVs. Compared with M1-EVs, miR-146a-5p, considered the key factor in TIME regulation, was deficient in M2-EVs according to miRNA-sequencing. When the miR-146a-5p mimic was added, EMT signatures and the invasive and migratory abilities of GBM cells were correspondingly weakened. Public databases predicted the miRNA binding targets and interleukin 1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor receptor-associated factor 6 (TRAF6) were screened as miR-146a-5p binding genes. Bimolecular fluorescent complementation and coimmunoprecipitation confirmed interactions between TRAF6 and IRAK1. The correlation between TRAF6 and IRAK1 was evaluated with immunofluorescence (IF)-stained clinical glioma samples. The TRAF6-IRAK1 complex is the switch and the brake that modulates IKK complex phosphorylation and NF-κB pathway activation, as well as the EMT behaviors of GBM cells. Furthermore, a homograft nude mouse model was explored and mice transplanted with TRAF6/IRAK1-overexpressing glioma cells had shorter survival times while mice transplanted with glioma cells with miR-146a-5p overexpression or TRAF6/IRAK1 knockdown lived longer. This work indicated that in the TIME of GBM, the deficiency of miR-146a-5p in M2-EVs enhances tumor EMT through disinhibition of the TRAF6-IRAK1 complex and IKK-dependent NF-κB signaling pathway providing a novel therapeutic strategy targeting the TIME of GBM.
NADPH oxidase mediated oxidative stress signaling in FLT3-ITD acute myeloid leukemia
Authors: Chen Yongfeng , Zou Zhenyou , Găman Mihnea-Alexandru , Xu Linglong , Li Jing 
Published: June 2023

AbstractThe internal tandem duplication of the juxtamembrane domain of the FMS-like tyrosine kinase 3 (FLT3-ITD) is the most common genetic change in acute myeloid leukemia (AML), and about 30% of all AMLs harbor a FLT3-ITD mutation. Even though FLT3 inhibitors have displayed encouraging effects in FLT3-ITD-mutated AML, the extent of the clinical response to these compounds is cut short due to the rapid development of drug resistance. Evidence has shown that FLT3-ITD triggered activation of oxidative stress signaling may exert a pivotal role in drug resistance. The downstream pathways of FLT3-ITD, including STAT5, PI3K/AKT, and RAS/MAPK, are considered to be major oxidative stress signaling pathways. These downstream pathways can inhibit apoptosis and promote proliferation and survival by regulating apoptosis-related genes and promoting the generation of reactive oxygen species (ROS) through NADPH oxidase (NOX) or other mechanisms. Appropriate levels of ROS may promote proliferation, but high levels of ROS can lead to oxidative damage to the DNA and increase genomic instability. In addition, post-translational modifications of FLT3-ITD and changes in its subcellular localization can affect downstream signaling which may also be one of the mechanisms leading to drug resistance. In this review, we summarized the research progress on NOX mediated oxidative stress signaling and its relationship with drug resistance in FLT3-ITD AML, and discuss the possible new targets in FLT3-ITD signal blocking to reverse drug resistance in FLT3-ITD-mutated AML.