bluuebunny/crossref_metadata_2025_split huggingface dataset:
The safe zone of distal fibula was determined based on the classification of lateral malleolus fossa
Authors: You Gui-xuan , Huang Lei , Li Ming-hui , Xiong Bin , Peng Wan-lin , Shi Hou-yin , Zhang Lei 
Published: September 2023

Abstract
Background
Lateral malleolus fractures are very common, and the distal fibular geometry is complex. This study aimed to classify the lateral malleolus fossa (MF) into different types by characterizing the lateral MF imaging morphology and exploring the relationship between the lateral MF and internal fixation position after distal fibula fractures.

Methods
Anteroposterior CT reconstruction was performed on 248 subjects. After reconstruction, the deepest point of the lateral MF was located, and then, the cross-sectional shape of the lateral MF was observed and classified.

Results
According to the morphology of the CT cross section, the lateral MF was divided into three types: type C (43.1%), type V (32.2%), and type Flat (24.7%). Type V (3.98 ± 0.82) was significantly longer than type C(2.83 ± 0.54) and type Flat (1.84 ± 0.42) in cd. Similarly, in ∠α, Type Flat(136.31 ± 9.63) was the largest, followed by type C (116.51 ± 8.79), and type V (89.31 ± 9.07) was the smallest. Other measurements were not found any significant differences between the above.

Conclusion
According to the morphology of the CT cross section, the lateral MF was divided into three types: type C, type V and type Flat. Type V is most likely to be invaded when fixing the distal fibula. Screws less than 9 mm should be selected when fixing, and screws no more than 10 mm should be selected when there are type C and type Flat of MF.
Determination of a safe sedative combination of dexmedetomidine, ketamine and butorphanol for minor procedures in dogs by use of a stepwise optimization method
Authors: Imboden Tobias Jonas , Pownall William Robert , Rubin Stéphanie , Spadavecchia Claudia , Schöllhorn Bernhard , Rohrbach Helene 
Published: September 2023

AbstractBackgroundIn veterinary practice, most minor procedures such as radiographs, skin biopsies, and wound treatments require sedation. The combination of butorphanol, ketamine, and dexmedetomidine is commonly used, but the ideal dosages for this combination have not been defined. This randomized prospective clinical 3-phases trial initially tested eight clinically relevant combinations of intramuscular administration in 50 dogs (phase 1). The quality of each combination was rated using a purposefully developed negative score (NS; 0-21.5, the lower the NS the better the quality of sedation) to judge the quality of sedation, the occurrence of side effects, and the need for additional anaesthetics. Based on the results of the NS, the eight combinations were divided into “promising” and “unsatisfactory” subgroups. In phase 2, a new combination (N) was calculated and tested in six dogs replacing the worst of the eight initial combinations. This procedure was repeated until the NS could not be improved any further. In phase 3, the best combination was tested in 100 adult dogs undergoing diagnostic or therapeutic procedures.ResultsThe optimal combination established was dexmedetomidine 0.005 mg/kg, ketamine 1 mg/kg, and butorphanol 0.3 mg/kg with a median NS of 1.5 (interquartile range 1.5–2.4). In all 112 dogs receiving this combination, the quality of sedation was satisfactory and no severe side effects were detected.ConclusionsThe application of this optimization method allowed the calculation of an optimal drug combination to sedate cardiovascularly healthy dogs. After having being tested in 112 animals, this combination can consequently be considered safe. Therefore, this combination can now be used in daily clinical practice for cardiovascularly healthy adult dogs undergoing minor procedures.
MEGADOCK-on-Colab: an easy-to-use protein–protein docking tool on Google Colaboratory
Authors: Ohue Masahito 
Published: September 2023

Abstract
Motivation
Since the advent of ColabFold, numerous software packages have been provided with Google Colaboratory-compatible ipynb files, allowing users to effortlessly test and reproduce results without the need for local installation or configuration. MEGADOCK, a protein–protein docking tool, is particularly well-suited for Google Colaboratory due to its lightweight computations and GPU acceleration capabilities. To increase accessibility and promote widespread use, it is crucial to provide a computing environment compatible with Google Colaboratory.

Results
In this study, we report the development of a Google Colaboratory environment for running our protein–protein docking software, MEGADOCK. We provide a comprehensive ipynb file, including the compilation of MEGADOCK with the FFTW library installation on Colaboratory, the introduction of related tools using PyPI/apt, and the execution and visualization of docking structures. This streamlined environment enables users to visualize docking structures with just one click. The code is available under a CC-BY NC 4.0 license from https://github.com/ohuelab/MEGADOCK-on-Colab.
Structural analysis and susceptibility inversion based on ground magnetic data to map the chromite mineral resources: a case study of the Koh Safi Chromite Ore Deposit, Parwan, Afghanistan
Authors: Rezayee Mohammad Hakim , Khalaj Mahdi , Mizunaga Hideki 
Published: September 2023

AbstractThe Koh Safi Chromite Ore Deposit is located in Afghanistan’s northern–northeastern end of the Kabul–Kandahar ophiolite zone. Sedimentary formations, delayed volcanic, and ultramafic rock groups, including peridotites and serpentinites, could all have been found in the Koh Safi area, where structural discontinuities with the two trends of northwest–southeast and east–west can be identified. High-grade serpentinite units have many chromite deposits, whereas peridotite has a lot of medium-grade deposits. This paper performs a ground magnetic data analysis based on structural analysis and 3-D susceptibility inversion. The boundaries of structural faults and anomalous bodies are likely delineated in a northwest-to-southeast orientation using a series of derivative maps, including Total Horizontal Derivative, Analytical Signal, and Theta Map. For inversion, many regularization norms that included the range of smooth, intermediate, and compact models were used to examine a particular susceptibility value that occurred in a model cell. The sparse and blocky norms [0,1,1,1] were suggested for our inversion in field data based on synthetic data to determine an appropriate norm. A 3-D inversion of ground magnetic data shows that the highly magnetic zone supposed to be the host rocks seems to be where chromite occurs in the study area.
Teamwork dynamics in the context of large-size software development courses
Authors: Magana Alejandra J. , Amuah Theodora , Aggrawal Sakhi , Patel Devang A. 
Published: September 2023

AbstractBackgroundEffectively facilitating teamwork experiences, particularly in the context of large-size courses, is difficult to implement. This study seeks to address the challenges of implementing effective teamwork experiences in large courses. This study integrated teamwork pedagogy to facilitate a semester-long project in the context of a large-size class comprising 118 students organized into 26 teams. The data for this study were collected from two online teamwork sessions when teams collaborated and self-recorded during the in-class time. The video recordings were qualitatively analyzed to identify patterns in team dynamics processes through visualizations. The study aims to provide insights into the different ways team members engaged in team dynamics processes during different phases of the semester.ResultsFindings suggest that members of teams were mostly active and passive during meetings and less constructive and interactive in their engagement. Team members mainly engaged in communication, team orientation, and feedback behaviors. Over time, team members' interactions with one another remained about the same, with feedback behaviors tending to diminish and coordination behaviors staying about the same or slightly increasing over time.ConclusionThe implications of this study extend to both practice and theory. Practically, combining cooperative learning and scrum practices enabled a blend of collaborative and cooperative work, which suggests providing teams with tools and structures to coordinate teamwork processes and promote interaction among team members. From a theoretical perspective, this study contributes to the understanding of temporal aspects of teamwork dynamics by examining how team interactions evolve during working sessions at different points in time. Overall, this research provides valuable insights for educators, practitioners, and researchers aiming to enhance teamwork experiences in large courses, particularly in software development disciplines.
Motivation, anxiety, and self-efficacy in learning aviation English: a study of Indonesian aviation cadets
Authors: Rochmawati Laila , Fatmawati  , Sukma Meita Maharani 
Published: September 2023

AbstractIndonesian aviation cadets’ complex and multi-faceted tasks have directed them to exhaustion and less learning focus. Their motivation and self-efficacy in learning Aviation English are hampered so their anxiety dominates. This hypothetical cause and effect enforce the present study to describe their motivation, anxiety, and self-efficacy in learning Aviation English. The present study also aimed to reveal the effect of each construct on their learning performance and identify the most predictive sub-skills that contribute to their motivation, anxiety, and self-efficacy formation. This study used a cross-sectional survey research design with a quantitative research approach. There were 207 aviation cadets chosen purposively to participate in the study. Data were collected using the Motivation, Anxiety, and Self-Efficacy Scale (MASS) with a 6-point Likert’s scaling method (α = .987) and cadets’ final test scores. Data were analyzed using descriptive statistics, Pearson r correlation, and hierarchical multiple regression with the assistance of SPSS software. Results showed that cadets’ motivation, anxiety, and self-efficacy in learning Aviation English were high, thus, their learning optimism and pessimism were growing together. Each variable had a positive and strong relationship with one other (r > .05, p < .001). Another finding was that communication and test anxiety was the most influencing factor in determining cadets’ learning performance.
Mediation effect of anxious attachment on relationship between childhood trauma and suicidal ideation sensitive to psychological pain levels
Authors: Ihme Hannah , Courtet Philippe , Risch Nathan , Dubois Jonathan , Belzeaux Raoul , Olié Emilie 
Published: September 2023

AbstractBackgroundChildhood trauma (CT), depression, and psychological pain are known predictors of suicidal ideation. Recent literature additionally highlights the importance of the attachment system.MethodsWe aimed to predict suicidal ideation through CT, attachment, and psychological and social pain by using mediation models aiming to predict suicidal ideation through CT (predictor) and attachment (mediator). In the same models, we introduced psychological or social pain as a moderator of the relationship between attachment, CT, and suicidal ideation. We included 161 depressed patients and assessed depression, attachment, CT, suicidal ideation, psychological pain, and social pain.ResultsWe found (1) a complete mediating effect of anxious attachment (a2b2= 0.0035, CI95%= [0.0010; 0.0069]) on the relationship between CT on suicidal ideation, and (2) a significant complete conditional mediating effect of anxious attachment and psychological pain (index of moderated mediation VAS: 0.0014; CI95%= [0.0002; 0.0032]) but not social pain on the relationship between CT and suicidal ideation. Both models were controlled for history of suicidal attempt, depression severity, and sex.ConclusionsOur results suggest a developmental profile of suicidal ideation in mood disorder that is characterized by the presence of CT and insecure attachment, especially anxious attachment, that is sensitive to experiences of psychological pain. Nevertheless, we cannot conclude that avoidantly attached individuals do not present the same mechanism, as they may not disclose those ideas.
Vitamin D Deficiency Increases Vulnerability to Canagliflozin-induced Adverse Effects on 1,25-Dihydroxyvitamin D and PTH
Authors: Shahidzadeh Yazdi Zhinous , Streeten Elizabeth A , Whitlatch Hilary B , Montasser May E , Beitelshees Amber L , Taylor Simeon I 
Published: September 2023

Abstract

Context
Canagliflozin has been reported to increase the risk of bone fracture—possibly mediated by decreasing 1,25-dihydroxyvitamin D (1,25(OH)2D) and increasing parathyroid hormone (PTH).

Objective
This work investigated whether baseline vitamin D (VitD) deficiency renders individuals vulnerable to this adverse effect and whether VitD3 supplementation is protective.

Methods
This community-based, outpatient study had a paired design comparing individual participants before and after VitD3 supplementation. Eleven VitD-deficient (25-hydroxyvitamin D [25(OH)D] ≤ 20 ng/mL) individuals were recruited from the Amish population in Lancaster, Pennsylvania. Participants underwent 2 canagliflozin challenge protocols (300 mg daily for 5 days): the first before and the second after VitD3 supplementation. In the VitD3 supplementation protocol, participants received VitD3 supplementation (50 000 IU once or twice a week depending on body mass index for 4-6 weeks) to achieve 25(OH)D of 30 ng/mL or greater. Two coprimary end points were identified: effects of VitD3 supplementation on canagliflozin-induced changes in 1,25(OH)2D and PTH. Secondary end points included effects of VitD3 supplementation on baseline levels of VitD metabolites and PTH.

Results
VitD3 supplementation increased mean 25(OH)D from 16.5 ± 1.6 to 44.3 ± 5.5 ng/mL (P = .0006) and 24,25-dihydroxyvitamin D (24,25(OH)2D) from 1.0 ± 0.1 to 4.3 ± 0.6 ng/mL (P = .0002). Mean 1,25(OH)2D and PTH were unchanged. VitD3 supplementation decreased the magnitude of canagliflozin-induced changes in 1,25(OH)2D (from −31.3%±4.7% to −9.3%±8.3%; P = .04) and PTH (from +36.2%±6.2% to +9.7%±3.7%; P = .005).

Conclusion
VitD deficiency rendered individuals more vulnerable to adverse effects of canagliflozin on biomarkers associated with bone health. VitD3 supplementation was protective against canagliflozin's short-term adverse effects on 1,25(OH)2D and PTH.
Association of Circulating Very Long-Chain Saturated Fatty Acids With Cardiovascular Mortality in NHANES 2003-2004, 2011-2012
Authors: Tao Xinmiao , Liu Lin , Ma Pingnan , Hu Jinxia , Ming Zhu , Dang Keke , Zhang Yuntao , Li Ying 
Published: September 2023

Abstract

Context
Limited studies have shown a protective effect of very long-chain saturated fatty acids (VLSFAs) on healthy aging, diabetes, heart failure, and risk factors related to cardiovascular disease (CVD), but the role of VLSFAs on mortality risk is unclear.

Objective
We aimed to investigate the association of serum docosanoic acid (C22:0) and serum lignoceric acid (C24:0) with all-cause and disease-specific mortality and to confirm the effect of VLSFAs on mortality risk in the whole, hyperlipidemia, and hypertensive populations.

Methods
A total of 4132 individuals from the 2003-2004, 2011-2012 National Health and Nutrition Examination Survey (NHANES) were included in this study. There were 1326 and 1456 participants in the hyperlipidemia and hypertensive population, respectively. Mortality information was confirmed using the National Death Index (NDI). Multiple model calibration was performed using Cox regression analysis for known risk factors to explore the association between circulating VLSFAs and all-cause or CVD or coronary heart disease (CHD) mortality.

Results
In the whole population, individuals with higher circulating C22:0 and C24:0 as a percentage of total serum fatty acid levels reduced the risks of mortality of all-cause (C22:0: HR = .409; 95% CI, 0.271-0.618; C24:0: HR = 0.430; 95% CI, 0.283-0.651), CVD (C22:0: HR = 0.286; 95% CI, 0.134-0.612; C24:0: HR = 0.233; 95% CI, 0.101-0.538), and CHD (C22:0: HR = 0.401; 95% CI, 0.187-0.913; C24:0: HR = 0.263; 95% CI, 0.082-0.846). Similar to the whole population, individuals with higher circulating C22:0 and C24:0 as a percentage of total serum fatty acid levels in the hyperlipidemia and hypertensive populations were also protective for all-cause, CHD, and CVD mortality.

Conclusion
Our results confirm the protective effect of high levels of circulating VLSFAs (C22:0 and C24:0) on CVD, CHD, and all causes of death in the whole, hyperlipidemia, and hypertensive populations.
TSH and FT4 Reference Interval Recommendations and Prevalence of Gestational Thyroid Dysfunction: Quantification of Current Diagnostic Approaches
Authors: Osinga Joris A J , Derakhshan Arash , Feldt-Rasmussen Ulla , Huang Kun , Vrijkotte Tanja G M , Männistö Tuija , Bassols Judit , López-Bermejo Abel , Aminorroaya Ashraf , Vafeiadi Marina , Broeren Maarten A C , Palomaki Glenn E , Ashoor Ghalia , Chen Liangmiao , Lu Xuemian , Taylor Peter N , Tao Fang-Biao , Brown Suzanne J , Sitoris Georgiana , Chatzi Lida , Vaidya Bijay , Popova Polina V , Vasukova Elena A , Kianpour Maryam , Suvanto Eila , Grineva Elena N , Hattersley Andrew , Pop Victor J M , Nelson Scott M , Walsh John P , Nicolaides Kypros H , D’Alton Mary E , Poppe Kris G , Chaker Layal , Bliddal Sofie , Korevaar Tim I M 
Published: September 2023

Abstract

Context
Guidelines recommend use of population- and trimester-specific thyroid-stimulating hormone (TSH) and free thyroxine (FT4) reference intervals (RIs) in pregnancy. Since these are often unavailable, clinicians frequently rely on alternative diagnostic strategies. We sought to quantify the diagnostic consequences of current recommendations.

Methods
We included cohorts participating in the Consortium on Thyroid and Pregnancy. Different approaches were used to define RIs: a TSH fixed upper limit of 4.0 mU/L (fixed limit approach), a fixed subtraction from the upper limit for TSH of 0.5 mU/L (subtraction approach) and using nonpregnancy RIs. Outcome measures were sensitivity and false discovery rate (FDR) of women for whom levothyroxine treatment was indicated and those for whom treatment would be considered according to international guidelines.

Results
The study population comprised 52 496 participants from 18 cohorts. Compared with the use of trimester-specific RIs, alternative approaches had a low sensitivity (0.63-0.82) and high FDR (0.11-0.35) to detect women with a treatment indication or consideration. Sensitivity and FDR to detect a treatment indication in the first trimester were similar between the fixed limit, subtraction, and nonpregnancy approach (0.77-0.11 vs 0.74-0.16 vs 0.60-0.11). The diagnostic performance to detect overt hypothyroidism, isolated hypothyroxinemia, and (sub)clinical hyperthyroidism mainly varied between FT4 RI approaches, while the diagnostic performance to detect subclinical hypothyroidism varied between the applied TSH RI approaches.

Conclusion
Alternative approaches to define RIs for TSH and FT4 in pregnancy result in considerable overdiagnosis and underdiagnosis compared with population- and trimester-specific RIs. Additional strategies need to be explored to optimize identification of thyroid dysfunction during pregnancy.
Bacteriophage-Conjugated Fluorescent Nanoemulsion as a Novel Optical Probe for Highly Selective Bacterial Detection
Authors: Sekida Shin-ya , Chisaka Takatoshi , Uchiyama Jumpei , Takemura-Uchiyama Iyo , Matsuzaki Shigenobu , Niko Yosuke , Hadano Shingo , Watanabe Shigeru 
Published: September 2023

Abstract
Infectious disease mortality has decreased due to effective drugs and healthcare. However, global health remains threatened by infectious diseases. New methods of rapid and accurate bacterial detection have attracted considerable attention. Fluorescence detection of whole bacterial cells offers high sensitivity, quantitative analysis, and simple operation. A highly fluorescent bioconjugated probe improves sensitivity and selectivity. This study presents a novel, bright fluorescent probe comprising a bacteriophage and a fluorescent nanoemulsion (fNE) as biorecognition and signal transduction elements, respectively. We demonstrate that fluorescence microscopy imaging using the S. aureus-specific phage, S13′-fNE (phage-fNE), detects S. aureus in the presence of E. coli or S. pseudintermedius, another closely related Staphylococci, in a highly selective manner. Furthermore, fNEs with high dye loadings exhibit considerably greater brightness compared to the fluorescent dye alone, making them suitable for sensitive fluorescence imaging. Phage-fNEs can quantitatively detect S. aureus at 104–108 colony-forming units per milliliter (CFU mL−1), with a limit of detection of 8 × 104 CFU mL−1. This result is comparable to the lowest value achieved by microscopic bacterial detection, with no preconcentration or enzymatic signal enhancement methods used. Bioconjugated fNEs open new avenues for highly selective and sensitive fluorescent detection of bacteria.
Correlations between APACHE-II score and pressure parameters of mechanical ventilation in patients with ARDS and their value in prognostic evaluation
Authors: Lu Wei , Zhang Jiansong , Qiu Yao , Fei Na , Yin Liansen 
Published: September 2023

Objective: To investigate the correlations between APACHE-II score and pressure parameters of mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) and their value in prognostic evaluation.
Methods: This was a retrospective study. The clinical data of 79 patients with ARDS treated in Shengzhou Hospital of Traditional Chinese Medicine from April 2020 to April 2022 were analyzed retrospectively. According to whether their APACHE-II scores were higher than 15, they were divided into low score group (n= 20) and high score group (n= 59). The plateau pressure (Pplat), driving pressure(ΔP) and mean airway pressure (Pmean) were compared. The correlation between APACHE-II score and pressure parameters of mechanical ventilation was analyzed. Based on the follow-up of 28-d survival, their Pplat, ΔP, Pmean and APACHE-II scores were compared. The value of APACHE-II score and pressure parameters in the prognostic evaluation of ARDS patients was analyzed.
Results: Pplat, ΔP and Pmean in the low score group were significantly lower than those in the high score group(P<0.05). Pplat, ΔP, Pmean and APACHE-II score in the survival group were significantly lower than those in the control group(P<0.05). APACHE-II score showed significantly positive correlations with Pplat, ΔP and Pmean. The AUC of Pmean, Pplat, ΔP and APACHE-II score in predicting the prognosis and diagnosis of ARDS patients was 0.761, 0.833, 0.754 and 0.832, respectively.
Conclusion: APACHE-II score of ARDS patients shows significantly positive correlations with pressure parameters of mechanical ventilation, and has diagnostic value for the prognosis of ARDS patients.
doi: https://doi.org/10.12669/pjms.39.6.7190
How to cite this: Wei Lu, Jiansong Zhang, Yao Qiu, Na Fei, Liansen Yin. Correlations between APACHE-II score and pressure parameters of mechanical ventilation in patients with ARDS and their value in prognostic evaluation. Pak J Med Sci. 2023;39(6):1584-1588. doi: https://doi.org/10.12669/pjms.39.6.7190
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.