bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectory Control Using Fuzzy Logic Applied to a Parallel Robot
Authors: de Sena Alexander Patrick Chaves , Junior Acarcio Gomes de Almeida 
Published: March 2023

Abstract
This work presents the development of Mamdani-type fuzzy controllers for tracking linear trajectories in the workspace of a delta-type linear parallel robot. The system comprises three positioner actuators driven by direct current motors with incremental encoders for displacement reading. A multifunctional data module made the interface between the computer and the machine, capturing the signals coming from the encoders and supplying the control signals to the power circuits that drive the motors. Labview® software was used to implement the controller, using the fuzzy logic toolkit, and Matlab® to analyze and present the experimental results. There are three phases of control: velocity control, position control with trajectory tracking, and trajectory generation. In the analysis of the system's response curves and the obtained data, it was verified a very satisfactory performance of the controllers acting with 100 mm/s. The maximum steady-state error was -1.50mm for X-axis motion, -1.76mm for Y-axis motion, and 1.02mm for Z-axis motion, resulting in a trajectory tracking error of 1.26%.
Intersection of Policy and Immunization Information Systems (IIS)
Authors: Heersema Lara A. , Cunniff Luke , Eiden Amanda , Sharma Isha , Mishra Jaya , Bhatti Alexandra 
Published: March 2023

Abstract
Background:
Immunization information systems (IIS) are confidential, population-based computerized databases that record vaccination doses administered to persons residing within a given geopolitical area. They play a pivotal role in achieving equitable and high vaccine uptake. In the United States (US), they are implemented and managed at the state and local level, creating variability in IIS policies.
Methods:
We conducted a legal assessment of relevant IIS statutes and administrative codes across all 50 states, the District of Columbia, Philadelphia, and New York City. Where relevant, laws were cross-checked or supplemented with state and local health department resources. Comparisons to previous legal studies were used to evaluate trends in IIS laws over time.
Results:
The compilation of these laws provides an updated overview of the diverse inter- and intra-state policies within the US that govern the capabilities and implementation of IIS. The findings of this study show that while progress has been made in improving the policies to enable and enhance IIS, gaps in IIS data collection, limited interoperability with local and national health information systems, and inconsistent access to IIS to view or utilize records, limits the full potential of IIS.
Conclusions:
Findings from this study help shine a light on the evolution of IIS policy over the last two decades, serve as a comprehensive benchmark for future analyses, and may help policy stakeholders who are exploring amending jurisdictional IIS laws.
Circadian disturbances and frailty risk in older adults: a prospective cohort study
Authors: Cai Ruixue , Gao Lei , Gao Chenlu , Yu Lei , Zheng Xi , Bennett David , Buchman Aron , Hu Kun , Li Peng 
Published: March 2023

Abstract
Frailty is characterized by diminished resilience to stressor events. It associates with adverse future health outcomes and impedes healthy aging. The circadian system orchestrates a ~24-h rhythm in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an important role in many age-related health consequences. We investigated prospective associations of circadian disturbances with incident frailty in over 1,000 older adults who had been followed annually for up to 16 years. We found that decreased rhythm strength, reduced stability, or increased variation, were associated with a higher risk of incident frailty, and faster worsening of the overall frailty symptoms over time. Perturbed circadian rest-activity rhythms may be an early sign or risk factor for frailty in older adults.
Epidemiology of premenopausal osteoporosis in Japan: a retrospective cohort study based on real-world data
Authors: Kasahara Kyoko , Tanaka-Mizuno Sachiko , Tsuji Shunichiro , Ohashi Mizuki , Kasahara Makiko , Kawasaki Taku , Murakami Takashi 
Published: March 2023

Abstract
We aimed to characterize the clinical features of premenopausal osteoporosis in Japan and evaluate medical interventions after fracture diagnosis. From a nationwide Japanese administrative claims database, we extracted 105,931 records of women regarding date of childbirth and divided them into two groups based on presence of a fragility fracture diagnostic code. From the records, we identified 231 women who had suffered a low-trauma fracture at reproductive age as the case group, and we randomly selected 1000 women as the control group. Age at childbirth was significantly higher (P = 0.00146) and estrogen-deficient conditions were significantly more frequent in the case than in the control group (odds ratio = 2.97, 95% confidence interval: 1.57–5.63). The most common fracture site was the vertebrae (35.2%), and fractures were also frequent in the 18 months around childbirth (32.9%). More than half of these fracture types overlapped, with significantly more opportunities for bone densitometry, an osteoporosis diagnosis, and antiosteoporosis pharmacotherapyfor these than for other fracture types, which were seldom treated as osteoporosis. Therefore, vertebral fractures and fracturesaround childbirth are a representative subtype of premenopausal osteoporosis. More medical attention isrecommended for all cases of premenopausal osteoporosis to reduce future fracture risk.
Adrenal insufficiency management in the pediatric emergency setting and risk factors for adrenal crisis development
Authors: Abrigo Enrica , Munarin Jessica , Bondone Claudia , Tuli Gerdi , Castagno Emanuele , de Sanctis Luisa , Matarazzo Patrizia 
Published: March 2023

Abstract
Background: In patients with adrenal insufficiency (AI), adrenal crisis (AC) represents a clinical emergency. Early recognition and prompt management of AC or AC-risk conditions in the Emergency Department (ED) can reduce critical episodes and AC-related outcomes. The aim of the study is to report the clinical and biochemical characteristics of AC presentation to improve their timely recognition and proper management in a ED setting.
Methods: Single-centre, retrospective, observational study on pediatric patients followed at the Department of Pediatric Endocrinology of Regina Margherita Children's Hospital of Turin for primary AI (PAI) and central AI (CAI).
Results: Among the 89 children followed for AI (44 PAI, 45 CAI), 35 patients (21 PAI, 14 CAI) referred to the PED, for a total of 77 accesses (44 in patients with PAI and 33 with CAI). The main causes of admission to the PED were gastroenteritis (59.7%), fever, hyporexia or asthenia (45.5%), neurological signs and respiratory disorders (33.8%). The mean sodium value at PED admission was 137.2 ± 1.23 mmol/l and 133.3 ± 1.46 mmol/l in PAI and CAI, respectively (p= 0.05). Steroids administration in PED was faster in patients with CAI than in those with PAI (2.75 ± 0.61 and 3.09 ± 1.47 hours from PED access, p=0.83).
Significant factors related to the development of AC were triage code (yellow and red codes, p=0.09), signs of dehydration at admission (p=0.027) and lack of intake or increase of usual steroid therapy at home (p= 0.059).
Endocrinological consulting was requested in 69.2% of patients with AC and 48.4% of subjects without AC (p= 0.032).
Conclusion: children with AI may refer to the PED with an acute life-threatening condition that needs prompt recognition and management. These preliminary data indicate how critical the education of children and families with AI is to improve the management at home, and how fundamental the collaboration of the pediatric endocrinologist with all PED personnel is in raising awareness of early symptoms and signs of AC to anticipate the proper treatment and prevent or reduce the correlated serious events.
Sponge-derived matter is assimilated by coral holobionts
Authors: Reigel Alicia , Easson Cole , Apprill Amy , Freeman Christopher , Bartley Michaela , Fiore Cara 
Published: March 2023

Abstract
Coral reef biodiversity is maintained by a complex network of nutrient recycling among organisms. Sponges contribute by assimilating nutrients produced by other organisms like coral and algae, and releasing them as particulate and dissolved matter, but to date, only a single trophic link (to a macroalgae) fueled by sponge-derived matter has been identified. We sought to determine if sponge-coral nutrient exchange is reciprocal using a stable isotope ‘pulse-chase’ experiment to trace the uptake of sponge-derived matter by the coral holobiont. Caribbean sponges were incubated with inorganic 13C and 15N tracer compounds, then placed into aquaria containing fragments from three coral species (Acropora cervicornis, Orbicella faveolata, and Eunicea flexuosa). Coral holobionts incorporated 2.3-26.8x more 15N than 13C from sponge-derived matter, and A. cervicornis and its symbiotic micro-algae (Symbiodiniaceae) incorporated more of both elements than the other corals. E. flexuosa host and Symbiodiniaceae fractions incorporated comparable 13C and 15N, suggesting an equal propensity to assimilate sponge-derived matter. Variable isotopic incorporation among coral species aligns with their ecophysiological characteristics. Our results confirm the reciprocal nature of the sponge-coral nutrient exchange and elucidate a novel trophic pathway that has implications for improving coral aquaculture and management approaches.
Profile of Eye-Related Emergency Department Visits in Ontario – A Canadian Perspective
Authors: Nanji Keean , Gulamhusein Husayn , Jindani Yasmin , Hamilton David , Sabri Kourosh 
Published: March 2023

Abstract
Background: Understanding the epidemiology of ophthalmic presentations to emergency departments can help guide resource allocation, medical education programs, and optimize the patient experience. The purpose of this investigation was to summarize and assess the urgency of ophthalmic presentations in emergency departments (EDs) in Ontario, Canada over a 5-year period.
Methods: This was a multicentered retrospective review of all patient presentations to EDs in Ontario between January 1st, 2012, to December 31st, 2017. Presentations were included if patients had an ophthalmic related ICD-10 code as their primary problem prompting ED presentation. Patients under the age of 18 were excluded from this investigation.
Results: A total of 774,057 patients patient presentations were included across the pediatric (149,679 patients) and adult (624,378 patients) cohorts. The mean (SD) age at presentation was 47.4 (17.9) years, and 6.54 (5.20) in the adult and pediatric cohorts respectively. Of the total presentations, 256,776 (33.1%) were due to a trauma related presentation. Problems pertaining to Cornea and External disease were the most common reason for presentation (51.0% of cases). Of all presentations, 34.1% were classified as either ‘emergent’ or ‘likely emergent’; the remaining presentations were either ‘non-emergent’ (39.5%) or the urgency ‘could not be determined’ (26.4%). The three most frequent presentations were due to conjunctivitis (121,175 cases or 15.7%), ocular foreign bodies (104,322 cases or 13.5%), and corneal / conjunctival abrasions (94,554 cases of 12.2%).
Conclusions: This investigation summarizes all ophthalmic presentations to EDs in Ontario, Canada over a 5-year period. The results of this investigation can help guide ophthalmic related knowledge translation. Additionally, these results highlight that in Canadian EDs, a significant proportion of ophthalmic presentations are nonurgent; systems level efforts to improve access for eye-related complaints to healthcare professionals outside of the ED can help facilitate improved resource allocation. As we emerge from the COVID-19 pandemic, optimising the structure of patient care access is crucial to help alleviate the pressure from overburdened EDs while effectively meeting patient healthcare needs.
Extremely Large Lamb Shift in a Deep-strongly Coupled Circuit QED System with a Multimode Resonator
Authors: Ao Ziqiao , Ashhab Sahel , Yoshihara Fumiki , Fuse Tomoko , Kakuyanagi Kosuke , Saito Shiro , Aoki Takao , Semba Kouichi 
Published: March 2023

Abstract
We report experimental and theoretical results on the extremely large Lamb shift in a multimode circuit quantum electrodynamics (QED) system in the deep-strong coupling (DSC) regime, where the qubit-resonator coupling strength is comparable to or larger than the qubit and resonator frequencies . The system comprises a superconducting flux qubit (FQ) and a quarter-wavelength coplanar waveguide resonator (λ/4 CPWR) that are coupled inductively through a shared edge that contains a Josephson junction to achieve the DSC regime. Spectroscopy is performed around the frequency of the fundamental mode of the CPWR, and the spectrum is fitted by the single-mode quantum Rabi Hamiltonian to obtain the system parameters. Since the qubitis also coupled to a large number of higher modes in the resonator, the single-mode fitting does not provide the bare qubit energy but a value that incorporates the renormalization from all the other modes. We derive theoretical formulas for the Lambshift in the multimode resonator system. As shown in previous studies, there is a cut-off frequency ω_{cutoff} for the coupling between the FQ and the modes in the CPWR, where the coupling grows as √ωn for ω_n/ωcutoff ≪ 1 and decreases as 1/√ωn for ωn/ωcutoff ≫ 1. Here ωn is the frequency of the nth mode. The cut-off effect occurs because the qubit acts as an obstacle forthe current in the resonator, which suppresses the current of the modes above ωcutoff at the location of the qubit and results ina reduced coupling strength. Using our observed spectrum and theoretical formulas, we estimate that the Lamb shift from the fundamental mode is 82.3% and the total Lamb shift from all the modes is 96.5%. This result illustrates that the coupling to thelarge number of modes in a CPWR yields an extremely large Lamb shift but does not suppress the qubit energy to zero, which would happen in the absence of a high-frequency cut-off.
Microsatellite maker analysis reveals the low genetic diversity in an endangered fish, Osteobrama belangeri in the Indo-Myanmar region
Authors: Rakkannan Gowrimanohari , Kashyap Shubham , Debnath Bijaya , Sahoo Dibyajyoti , Singh Yambem Suresh , Patel Arun Bhai , Priyadarshi Himanshu 
Published: March 2023

Abstract
Background
Pengba (Osteobrama belangeri) is a medium carp endemic to Manipur with favorable characteristics for poly-culture and a great demand for its texture. Moreover, pengba is listed as a Near-threatened species according to the IUCN and the study on genetic characterization of this species is scanty. The lack of studies on the population structure of this species is significant from the conservation point of view, thus the present study aimed to validate selected anonymous and gene-associated (growth and sex-traits related) microsatellites obtained by whole genome sequencing using Illumina next-generation sequencing.
Results
In general, the evaluation of 106 markers resulted in 13 polymorphic loci, of which 7 were gene-associated and 6 were anonymous using Whole Genome Sequenced data of O. belangeri. The mean observed heterozygosity of culture and wild populations ranged from 0.050 to 0.850 and expected heterozygosity ranged from 0.095 to 0.728, respectively. The grand average of the number of alleles (Na) and the number of effective alleles (Ne) are 2.192 and 1.602.
Conclusion
This study infers a significant lack of genetic diversity due to low heterozygosity in the culture and wild populations of Osteobrama belangeriwhere irresponsible ranching could be a reason. Additionally, the developed polymorphic microsatellites in the current study are the first molecular markers available for genetic studies in O. belangeri, which could be used for the construction of a genetic map and search for Quantitative Trait Loci (QTL) which ultimately helps in Molecular Assisted Selection (MAS) in the future studies.
Comparison of intracorporeal and extracorporeal anastomosis for left or sigmoid colectomy: updated meta-analysis of retrospective control trials
Authors: Yao Qing , Fu Ya-Yan , Sun Qian-Nan , Ren Jun , Wang Liu-Hua , Wang Daorong 
Published: March 2023

Abstract
Background: The feasibility and effectiveness of slecting intracorporeal anastomosis (IA) or extracorporeal anastomosis (EA) in left or sigmoid colectomy remained poorly comprehensive. This meta-analysis aimed to evaluate the difference between IA and EA in term of introperative and postoperative outcomes.
Methods: A comprehensive search of online databases (PubMed, Embase, Cochrane, and Web of Science) was conducted for for randomized controlled trials, cohort studies, and case control studies comparing the IA vusus EA in left or sigmoid colectomy. The outcomes of assessment contained four aspects like intraoperative outcomes, postoperative complications, postoperative patient condition, and postoperative outcomes. All of these data were analyzed using Rev Man 5.4
Results: eight retrospective control trials (IA, 453 patients; EA, 483 patients) were evaluated. Compared to group of EA, the IA group demonstrated priority in conversion (P<0.01), wound infection (P=0.01), overall complications (P<0.01), time to first flatus (P<0.01), time to first stool (P<0.01), time to first diet (P<0.01) and hospital stay duration (P<0.01).
Conclusions: Intracorporeal anastomosis is superior to the extracorporeal anastomosis in reducing postoperative complications, promoting postoperative recovery of gastrointestinal function and reducing hospital stay duration.
Development of a Multi-Level Family Planning Intervention for Couples in Rural Uganda: Key Findings &amp; Adaptations Made from Community Engaged Research Methods
Authors: Muhumuza C. M. , Sileo K. S. M. , Wanyenze R. W. , Kershaw T. K. S , Lule H. L. , Sekamatte S. S. , Kiene S. K. 
Published: March 2023

Abstract
Background: Uganda has among the highest fertility rates in the world and multi-level barriers contribute to the low contraceptive use.
Objective The objective of this study was to develop a culturally and socially relevant, community-based intervention to increase contraceptive use among couples in rural Uganda through community-engaged research methods. This study reports on the community-engaged research that informed the intervention’s content and structure and the final content of the intervention; the evaluation of the pilot intervention will be reported upon completion.
Methods: An intervention steering committee of community stakeholders reviewed the initially proposed intervention content and approach. Focus groups were conducted with men and women separately (N=26) who had unmet need for family planning. Fifteen key-informant interviews were conducted with community leaders and family planning stakeholders. Finally, the 4-session intervention was pilot tested with a cohort of couples (N=7) similar in demographics to the target sample of the future pilot intervention trial. Qualitative data were analyzed thematically.
Results: Findings included the identification of community beliefs to reshape to increase family planning acceptance, as well as strategies to engage men, acceptable approaches for community leader involvement in the intervention to endorse family planning, and methods for managing gender dynamics and minimizing risk of unintended negative consequences of participation. The findings were used to shape the ideal structure and format of the intervention, including the distribution of contraceptives directly during group sessions, and identified the need to strengthen health worker capacity to provide Long-Acting Reversable Contraceptives (LARCs) as part of the intervention.
Conclusions: These findings were used to refine an intervention before a larger scale pilot test of its feasibility, acceptability, and potential efficacy. They can inform other multi-level family planning interventions in similar settings and the methods can be adopted by others to increase the feasibility, acceptability, and cultural relevance of interventions.
Agomelatine augmentation of sertraline in the treatment of moderate to severe obsessive-compulsive disorder: a randomized double-blinded placebo-controlled clinical trial
Authors: Shokrani Marjan , Askari Sanaz , Eissazade Negin , Shariat Seyed Vahid , Shariati Behnam , Yarahmadi Masoomeh , Shalbafan Mohammadreza 
Published: March 2023

Abstract
Background: As 40-60% of the patients with obsessive-compulsive disorder (OCD) do not adequately respond to the first-line treatment, finding an effective second-line treatment is required. Our aim was to assess the efficacy and safety of agomelatine (a selective melatonin receptor agonist and a 5-hydroxytryptamine (HT)2C antagonist) augmentation of sertraline in the treatment of patients with moderate to severe OCD.
Methods: In this 12-week randomized, double-blinded, placebo-controlled, parallel-group clinical trial, 65 patients with moderate to severe OCD according to the Diagnostic and Statistical Manual of Mental Disorders-Fifth edition (DSM–5) criteria and a Yale-Brown obsessive compulsive scale (Y-BOCS) score of over 21, were included. They were assigned with sertraline (100 mg/day for the first 4 weeks and 200 mg/day for the next 8 weeks) and either agomelatine (25 mg/day) or placebo. The primary outcome was OCD symptoms measured by the Y-BOCS.
Results: Fifty patients (24 in agomelatine group and 26 in placebo group) completed the trial. The Y-BOCS scores in total (MD (95% CI) = 12.25 (11.00, 13.49) (p-value < 0.0001) vs. MD (95% CI) = 12.46 (6.65, 15.74) (p-value < 0.0001)), the obsession subscale (MD (95% CI) = 5.04 (4.19, 5.88) (p-value < 0.0001) vs. MD (95% CI) = 5.00 (3.84, 6.16) (p-value=0.0001)), and compulsion subscale (MD (95% CI) = 7.21 (6.34, 8.07) (p-value < 0.0001) vs. MD (95% CI) = 7.460 (6.50, 8.42) (p-value < 0.0001)) significantly decreased in both groups. Although, at the end of the trial, no significant difference was observed between the scores of the two groups in total (MD (95% CI) = 0.480 (-1.23, 2.19) (p-value= 0.78)), the obsession subscale (MD (95% CI) = 1.020 (-0.15, 2.19) (p-value=0.38)), and the compulsion subscale (MD (95% CI) = 0.540 (-0.34, 1.42) (p-value=0.54)). No major adverse effects were recorded, and the frequency of side effects was not significantly different between the groups.
Conclusion:Agomelatine in augmentation with sertraline is safe and tolerable in patients with moderate to severe OCD. However, our study does not support its efficacy in improving OCD symptoms, compared to placebo.
Trial registration: The trial was registered at the Iranian Registry of Clinical Trials on 14/07/2020 (www.irct.ir; IRCT ID: IRCT20170123032145N5).
Funding: The authors disclose receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by Iran University of Medical Sciences (Grant no: 98-4-75-16914).