bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted mechanical stimulation via magnetic nanoparticles guides in vitro tissue development
Authors: Abdel Fattah Abdel Rahman , Kolaitis Niko , Van Daele Katrien , Daza Brian , Rustandi Andika Gregorius , Ranga Adrian 
Published: August 2023

AbstractTissues take shape through a series of morphogenetic movements guided by local cell-scale mechanical forces. Current in vitro approaches to recapitulate tissue mechanics rely on uncontrolled self-organization or on the imposition of extrinsic and homogenous forces using matrix or instrument-driven stimulation, thereby failing to recapitulate highly localized and spatially varying forces. Here we develop a method for targeted mechanical stimulation of organoids using embedded magnetic nanoparticles. We show that magnetic clusters within organoids can be produced by sequential aggregation of magnetically labeled and non-labeled human pluripotent stem cells. These clusters impose local mechanical forces on the surrounding cells in response to applied magnetic fields. We show that precise, spatially defined actuation provides short-term mechanical tissue perturbations as well as long-term cytoskeleton remodeling in these organoids, which we term “magnetoids”. We demonstrate that targeted magnetic nanoparticle-driven actuation guides asymmetric tissue growth and proliferation, leading to enhanced patterning in human neural magnetoids. This approach, enabled by nanoparticle technology, allows for precise and locally controllable mechanical actuation in human neural tube organoids, and could be widely applicable to interrogate the role of local mechanotransduction in developmental and disease model systems.
An orexigenic subnetwork within the human hippocampus
Authors: Barbosa Daniel A. N. , Gattas Sandra , Salgado Juliana S. , Kuijper Fiene Marie , Wang Allan R. , Huang Yuhao , Kakusa Bina , Leuze Christoph , Luczak Artur , Rapp Paul , Malenka Robert C. , Hermes Dora , Miller Kai J. , Heifets Boris D. , Bohon Cara , McNab Jennifer A. , Halpern Casey H. 
Published: August 2023

AbstractOnly recently have more specific circuit-probing techniques become available to inform previous reports implicating the rodent hippocampus in orexigenic appetitive processing1–4. This function has been reported to be mediated at least in part by lateral hypothalamic inputs, including those involving orexigenic lateral hypothalamic neuropeptides, such as melanin-concentrating hormone5,6. This circuit, however, remains elusive in humans. Here we combine tractography, intracranial electrophysiology, cortico-subcortical evoked potentials, and brain-clearing 3D histology to identify an orexigenic circuit involving the lateral hypothalamus and converging in a hippocampal subregion. We found that low-frequency power is modulated by sweet-fat food cues, and this modulation was specific to the dorsolateral hippocampus. Structural and functional analyses of this circuit in a human cohort exhibiting dysregulated eating behaviour revealed connectivity that was inversely related to body mass index. Collectively, this multimodal approach describes an orexigenic subnetwork within the human hippocampus implicated in obesity and related eating disorders.
Anthropogenic fingerprints in daily precipitation revealed by deep learning
Authors: Ham Yoo-Geun , Kim Jeong-Hwan , Min Seung-Ki , Kim Daehyun , Li Tim , Timmermann Axel , Stuecker Malte F. 
Published: August 2023

AbstractAccording to twenty-first century climate-model projections, greenhouse warming will intensify rainfall variability and extremes across the globe1–4. However, verifying this prediction using observations has remained a substantial challenge owing to large natural rainfall fluctuations at regional scales3,4. Here we show that deep learning successfully detects the emerging climate-change signals in daily precipitation fields during the observed record. We trained a convolutional neural network (CNN)5 with daily precipitation fields and annual global mean surface air temperature data obtained from an ensemble of present-day and future climate-model simulations6. After applying the algorithm to the observational record, we found that the daily precipitation data represented an excellent predictor for the observed planetary warming, as they showed a clear deviation from natural variability since the mid-2010s. Furthermore, we analysed the deep-learning model with an explainable framework and observed that the precipitation variability of the weather timescale (period less than 10 days) over the tropical eastern Pacific and mid-latitude storm-track regions was most sensitive to anthropogenic warming. Our results highlight that, although the long-term shifts in annual mean precipitation remain indiscernible from the natural background variability, the impact of global warming on daily hydrological fluctuations has already emerged.
Relationship between bibliometric indicators and university ranking positions
Authors: Szluka Péter , Csajbók Edit , Győrffy Balázs 
Published: August 2023

AbstractA growing interest for demonstrating prestige and status of higher education institutions has spurred the establishment of several international ranking systems. A major percentage of these rankings include parameters related to scientific productivity. Here, we examined the differences between diverse rankings as well as correlation with bibliometric parameters and disciplines for the top universities. We investigated the top 300 universities from four international rankings, the Times Higher Education World University Ranking (THE), the QS World University Rankings (QS) the ShanghaiRanking-Academic Ranking of World Universities (ARWU) and the U.S.News Best Global Universities Ranking (USNews). The assessed parameters include ranking positions, size related and bibliometrics-related indicators of each selected ranking. The weight of scientometric parameters ranges between 20% (QS) and 75% (USNews). The most important parameters defining ranking positions include citations, international reputation, and the number of researchers, but the correlation strength varies among ranking systems. The absolute number of publications and citations are particularly important in ARWU and USNews rankings, and scientific category normalized (field weighted) citation impact is central in THE and USNews rankings. Our results confirm that universities having outstanding results in rankings using size-independent indicators (QS and THE) compared to others have significantly lower number of students. High impact research can improve position in ARWU and USNews ranking lists. Regarding to different disciplines, the main results show that outstanding universities in THE ranking have higher publication activity in social sciences and universities which perform better in USNews and QS ranking have more publications in science, technology, and medicine fields and lower score in social sciences. In brief, here we present a comprehensive analysis of the correlation between scientometric parameters and university ranking positions, as well as the performance of outstanding universities and their correlation with different disciplines, to help decision makers select parameters for strengthening and to attract the interest of prospective students and their parents via a better understanding of the functions of different ranks.
A display and analysis platform for gut microbiomes of minority people and phenotypic data in China
Authors: Li Jun , Wei Chunxue , Zhou Ting , Mo Chunfen , Wang Guanjun , He Feng , Wang Pengyu , Qin Ling , Peng Fujun 
Published: August 2023

AbstractThe minority people panmicrobial community database (MPPCD website: http://mppmcdb.cloudna.cn/) is the first microbe-disease association database of Chinese ethnic minorities. To research the relationships between intestinal microbes and diseases/health in the ethnic minorities, we collected the microbes of the Han people for comparison. Based on the data, such as age, among the different ethnic groups of the different regions of Sichuan Province, MPPCD not only provided the gut microbial composition but also presented the relative abundance value at the phylum, class, order, family and genus levels in different groups. In addition, differential analysis was performed in different microbes in the two different groups, which contributed to exploring the difference in intestinal microbe structures between the two groups. Meanwhile, a series of related factors, including age, sex, body mass index, ethnicity, physical condition, and living altitude, were included in the MPPCD, with special focus on living altitude. To date, this is the first intestinal microbe database to introduce altitude features. In conclusion, we hope that MPPCD will serve as a fundamental research support for the relationship between human gut microbes and host health and disease, especially in ethnic minorities.
Tracking the flight and landing behaviour of western flower thrips in response to single and two-colour cues
Authors: Lopez-Reyes Karla , Lankheet Martin J. , van Tol Robert W. H. M. , Butler Ruth C. , Teulon David A. J. , Armstrong Karen F. 
Published: August 2023

AbstractReal-time 3D tracking and high-speed videography was used to examine the behaviour of a worldwide greenhouse pest, the western flower thrips (WFT), in response to different colours in the context of improving trap design. Measurements were taken of the number of landings on, and flight activity near, a lamp containing two LEDs of either the same colour or a combination of two colours presented side by side. Main findings show that landing patterns of WFT are different between colours, with landings on UV(+ red) as highly attractive stimulus being mostly distributed at the bottom half of the lamp, while for yellow also as very attractive and green as a ‘neutral’ stimulus, landings were clearly on the upper rim of the lamp. Additionally, a positive interaction with the UV-A(+ red) and yellow combination elicited the highest number of landings and flight time in front of the LED lamp. Conversely, a negative interaction was observed with decreased landings and flight time found for yellow when blue was present as the adjacent colour. Overall, differences between treatments were less obvious for flight times compared to number of landings, with tracking data suggesting that WFT might use different colours to orientate at different distances as they approach a visual stimulus.
Analysis of marine heatwaves over the Bay of Bengal during 1982–2021
Authors: Kumar Sudhanshu , Chakraborty Arun , Chandrakar Raghvendra , Kumar Abhishek , Sadhukhan Biplab , Roy Chowdhury Riyanka 
Published: August 2023

AbstractAnomalous increase in sea surface temperature and its impact on natural ecosystems greatly interests the research community. Here we investigate the causes, impacts, and trends of marine heat wave (MHW) events in the Bay of Bengal (BoB) from 1982 to 2021. A total of 107 MHW events have been isolated (> 90th percentile threshold) in this Indian Ocean region, and their variation in intensity, duration, and frequency has been investigated. Our research unveils that an average of three MHW events/year accompanied by a linearly increasing trend of 1.11 MHW events/decade has been observed over the study region. It was also found that the most intense event was observed in 2016, which continued for 69 days, and had a maximum intensity of 5.29 °C and a mean intensity of 2.03 °C (above climatology mean). Moreover, it was observed that the net heat flux, along with anticyclonic eddies, was the primary cause of MHW events. Anticyclonic eddies associated with positive sea surface height anomaly were observed (> 0.20 m) in the vicinity of the most intense MHW event. Additionally, climate change and climate modes like El Niño and Indian Ocean Dipole show a high positive influence on the MHW events. Furthermore, we have examined the MHW event recurrence patterns in various regions of the BoB. From the monthly analysis, it was found that August and November had the most occurrences of MHWs, while April and May had the most extreme MHW events.
Experimental validation of rotating detonation for rocket propulsion
Authors: Bennewitz John W. , Burr Jason R. , Bigler Blaine R. , Burke Robert F. , Lemcherfi Aaron , Mundt Tyler , Rezzag Taha , Plaehn Ethan W. , Sosa Jonathan , Walters Ian V. , Schumaker S. Alexander , Ahmed Kareem A. , Slabaugh Carson D. , Knowlen Carl , Hargus William A. 
Published: August 2023

AbstractSpace travel requires high-powered, efficient rocket propulsion systems for controllable launch vehicles and safe planetary entry. Interplanetary travel will rely on energy-dense propellants to produce thrust via combustion as the heat generation process to convert chemical to thermal energy. In propulsion devices, combustion can occur through deflagration or detonation, each having vastly different characteristics. Deflagration is subsonic burning at effectively constant pressure and is the main means of thermal energy generation in modern rockets. Alternatively, detonation is a supersonic combustion-driven shock offering several advantages. Detonations entail compact heat release zones at elevated local pressure and temperature. Specifically, rotating detonation rocket engines (RDREs) use detonation as the primary means of energy conversion, producing more useful available work compared to equivalent deflagration-based devices; detonation-based combustion is poised to radically improve rocket performance compared to today’s constant pressure engines, producing up to 10$$\%$$
%
increased thrust. This new propulsion cycle will also reduce thruster size and/or weight, lower injection pressures, and are less susceptible to engine-damaging acoustic instabilities. Here we present a collective effort to benchmark performance and standardize operability of rotating detonation rocket engines to develop the RDRE technology readiness level towards a flight demonstration. Key detonation physics unique to RDREs, driving consistency and control of chamber dynamics across the engine operating envelope, are identified and addressed to drive down the variability and stochasticity observed in previous studies. This effort demonstrates an RDRE operating consistently across multiple facilities, validating this technology’s performance as the foundation of RDRE architecture for future aerospace applications.
Mechanisms and consequences of weight gain after deep brain stimulation of the subthalamic nucleus in patients with Parkinson’s disease
Authors: Steinhardt Julia , Lokowandt Laura , Rasche Dirk , Koch Andreas , Tronnier Volker , Münte Thomas F. , Meyhöfer Sebastian M. , Wilms Britta , Brüggemann Norbert 
Published: August 2023

AbstractBody weight gain in combination with metabolic alterations has been observed after deep brain stimulation (DBS) of subthalamic nucleus (STN) in patients with Parkinson’s disease (PD), which potentially counteracts the positive effects of motor improvement. We aimed to identify stimulation-dependent effects on motor activities, body weight, body composition, energy metabolism, and metabolic blood parameters and to determine if these alterations are associated with the local impact of DBS on different STN parcellations. We assessed 14 PD patients who underwent STN DBS (PD-DBS) before as well as 6- and 12-months post-surgery. For control purposes, 18 PD patients under best medical treatment (PD-CON) and 25 healthy controls (H-CON) were also enrolled. Wrist actigraphy, body composition, hormones, and energy expenditure measurements were applied. Electrode placement in the STN was localized, and the local impact of STN DBS was estimated. We found that STN DBS improved motor function by ~ 40% (DBS ON, Med ON). Weight and fat mass increased by ~ 3 kg and ~ 3% in PD-DBS (all P ≤ 0.005). fT3 (P = 0.001) and insulin levels (P = 0.048) increased solely in PD-DBS, whereas growth hormone levels (P = 0.001), daily physical activity, and VO2 during walking were decreased in PD-DBS (all P ≤ 0.002). DBS of the limbic part of the STN was associated with changes in weight and body composition, sedentary activity, insulin levels (all P ≤ 0.040; all r ≥ 0.56), and inversely related to HOMA-IR (P = 0.033; r = − 0.62). Daily physical activity is decreased after STN DBS, which can contribute to weight gain and an unfavorable metabolic profile. We recommend actigraphy devices to provide feedback on daily activities to achieve pre-defined activity goals.
Blunted startle reactivity in everyday sadism and psychopathy
Authors: Buckels Erin E. , Williams Douglas A. , Trapnell Paul D. , Kermani Koosheh Siavash , Javra Owen M. , Svenne Sasha C. 
Published: August 2023

AbstractTwo studies examined the amplitude of the startle response as a function of the Dark Tetrad of personality (narcissism, Machiavellianism, psychopathy, and sadism). We measured electromyographic activity of the orbicularis oculi muscle evoked by a startle stimulus while participants viewed images on a computer screen. Both studies revealed a negative correlation between general startle reactivity (averaged across positive, negative, and neutral images) and sadistic tendencies. In Study 2, all four dark traits were negative correlates of general startle reactivity. Study 2 also examined the personality correlates of aversive startle potentiation (ASP; indexed by greater reactivity while viewing negatively-valenced images than positive or neutral images). ASP correlated negatively with a variety of personality measures of psychopathy and sadism, their facets, and related personality tendencies (callousness, risk-taking, and restricted affect). These findings suggest that ordinary people with high levels of callousness and antagonism display physiological evidence of non-reactivity (i.e., blunted acoustic startle in general), whereas psychopathy and sadism are preferentially associated with reduced ASP.
ZnO doped C: Facile synthesis, characterization and photocatalytic degradation of dyes
Authors: Hosny Nasser Mohammed , Gomaa Islam , Elmahgary Maryam G. , Ibrahim Medhat A. 
Published: August 2023

AbstractCarbon doped ZnO nanoparticles have been synthesized from the thermal decomposition of Zinc citrate precursor. The precursor was synthesized from semi-solid paste and then subjected to calcination at 700 °C to produce ZnO nanoparticles. The precursor and ZnO were characterized by Fourier Transform Infrared Spectroscopy, UV–visible (UV–Vis) spectra, Transmission Electron Microscope, Field Emission Scanning Electron Microscope, Energy Dispersive Analysis by X-ray (EDAX), X-ray powder diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The results ensured the formation of hexagonal 2D-ZnO nanoparticles with a layer thickness of 25 nm. The optical band gap of ZnO was determined and found to be 2.9 eV, which is lower than the bulk. Photocatalytic degradation of Fluorescein dye as an anionic dye and Rhodamine B as a cationic dye was evaluated via C-ZnO NPs under UV irradiation. ZnO displayed 99% degradation of Fluorescein dye after 240 min and a complete photocatalytic degradation of Rhodamine B dye after 120 min under UV irradiation.
Neuronal morphology and synaptic input patterns of neurons in the intermediate nucleus of the lateral lemniscus of gerbils
Authors: Wicke Kathrin D. , Oppe Leon , Geese Carla , Sternberg Anna K. , Felmy Felix 
Published: August 2023

AbstractThe lateral lemniscus encompasses processing stages for binaural hearing, suppressing spurious frequencies and frequency integration. Within the lemniscal fibres three nuclei can be identified, termed after their location as dorsal, intermediate and ventral nucleus of the lateral lemniscus (DNLL, INLL and VNLL). While the DNLL and VNLL have been functionally and anatomically characterized, less is known about INLL neurons. Here, we quantitatively describe the morphology, the cellular orientation and distribution of synaptic contact sites along dendrites in mature Mongolian gerbils. INLL neurons are largely non-inhibitory and morphologically heterogeneous with an overall perpendicular orientation regarding the lemniscal fibers. Dendritic ranges are heterogeneous and can extend beyond the nucleus border. INLL neurons receive VGluT1/2 containing glutamatergic and a mix of GABA- and glycinergic inputs distributed over the entire dendrite. Input counts suggest that numbers of excitatory exceed the inhibitory contact sites. Axonal projections indicate connectivity to ascending and descending auditory structures. Our data show that INLL neurons form a morphologically heterogeneous continuum and incoming auditory information is processed on thin dendrites of various length and biased to perpendicular orientation. Together with the different axonal projection patterns, this indicates that the INLL is a highly complex structure that might hold many unexplored auditory functions.
SNR enhanced high-speed two-photon microscopy using a pulse picker and time gating detection
Authors: Song Jeonggeun , Kang Juehyung , Kang Ungyo , Nam Hyeong Soo , Kim Hyun Jung , Kim Ryeong Hyeon , Kim Jin Won , Yoo Hongki 
Published: August 2023

AbstractTwo-photon microscopy (TPM) is an attractive biomedical imaging method due to its large penetration depth and optical sectioning capability. In particular, label-free autofluorescence imaging offers various advantages for imaging biological samples. However, relatively low intensity of autofluorescence leads to low signal-to-noise ratio (SNR), causing practical challenges for imaging biological samples. In this study, we present TPM using a pulse picker to utilize low pulse repetition rate of femtosecond pulsed laser to increase the pulse peak power of the excitation source leading to higher emission of two-photon fluorescence with the same average illumination power. Stronger autofluorescence emission allowed us to obtain higher SNR images of arterial and liver tissues. In addition, by applying the time gating detection method to the pulse signals obtained by TPM, we were able to significantly reduce the background noise of two-photon images. As a result, our TPM system using the pulsed light source with a 19 times lower repetition rate allowed us to obtain the same SNR image more than 19 times faster with the same average power. Although high pulse energy can increase the photobleaching, we also observed that high-speed imaging with low total illumination energy can mitigate the photobleaching effect to a level similar to that of conventional illumination with a high repetition rate. We anticipate that this simple approach will provide guidance for SNR enhancement with high-speed imaging in TPM as well as other nonlinear microscopy.