bluuebunny/crossref_metadata_2025_split huggingface dataset:
The highs and the lows: Recreational marijuana laws and mental health treatment
Authors: Ortega Alberto 
Published: July 2023

AbstractRecreational marijuana laws (RMLs) continue to grow in popularity, but the effects on mental health treatment are unclear. This paper uses an event‐study within a difference‐in‐differences framework to study the short‐run impact of state RMLs on admissions into mental health treatment facilities. The results indicate that shortly after a state adopts an RML, they experience a decrease in the average number of mental health treatment admissions. The findings are driven by white, Black, and Medicaid‐funded admissions and are consistent for both male and female admissions. The results are robust to alternative specifications and sensitivity analysis.
Lymphadenopathy as a predictor of progression during venetoclax treatment in chronic lymphocytic leukemia. A campus chronic lymphocytic leukemia study
Authors: Autore Francesco , Innocenti Idanna , Reda Gianluigi , Visentin Andrea , Vitale Candida , Piciocchi Alfonso , Fresa Alberto , Leone Monica M. A. , Farina Lucia , Quaresmini Giulia , Baratè Claudia , Giordano Annamaria , Ferrari Angela , Angeletti Ilaria , De Paolis Maria Rosaria , Malerba Lara , Chiurazzi Federico , Loseto Giacomo , Catania Gioacchino , Sportoletti Paolo , Scortechini Ilaria , Moia Riccardo , Gentile Massimo , Rigolin Gian Matteo , Mattiello Veronica , Gattei Valter , Coscia Marta , Trentin Livio , Foà Robin , Cuneo Antonio , Laurenti Luca 
Published: July 2023

AbstractClinical or biological parameters useful to predict progression during treatment in real‐life setting with ibrutinib, idelalisib and venetoclax in relapsed/refractory chronic lymphocytic leukemia (CLL) are still debated. We conducted a multi‐center retrospective study on CLL patients treated with ibrutinib and/or idelalisib who were switched to venetoclax for progression or due to adverse events to identify any clinical and/or biological parameters useful to predict progression during treatment with venetoclax. Of all the 128 evaluable patients, 81 had received ibrutinib prior to switching to venetoclax, 35 had received idelalisib and 12 both. When comparing the three subgroups, we did not notice any statistical difference in terms of clinical or biological features. No variable at baseline and at different time points during the follow‐up (at 6, 12, 18 and 24 months) was found to predict progression nor to have significance for Progression Free Survival (PFS) in the ibrutinib group and in the idelalisib group and in subgroups according to the line of treatment. Analyzing the data of the venetoclax treatment, after a median follow up of 14.3 months, median PFS was not reached and estimated 3‐year PFS was 54%. Of the 128 patients treated with venetoclax, 28 (22%) experienced progressive disease. At multivariate analysis for predictive factors for progression, lymph node diameter >56.5 mm before starting treatment emerged as an independent risk factor for progression. The lymph node predictive role for progression during venetoclax treatment could be a new parameter that deserves to be investigate in future studies.
The impact of COVID‐19 pandemic lockdown on smoking habits and lifestyle: A cross‐sectional study
Authors: Khamees Almu'atasim , Awadi Sajeda , Rawashdeh Shireen , Talafha Muna , Alzoubi Mai , Almdallal Walaa , al‐Eitan Sharaf , Saeed Ahmad , Al‐Zoubi Raed M. , Al‐Zoubi Mazhar Salim 
Published: July 2023

AbstractBackground and AimsThroughout the COVID‐19 lockdown, the resultant psychological disturbances led to more tobacco consumption and deteriorated smoking behaviors among smokers. In this study, we aimed to investigate the impact of the COVID‐19 pandemic on the smoking behaviors of the Jordanian population.MethodsA cross‐sectional online survey was designed using the Google Forms service and distributed by social media platforms. Responses were collected starting from November 12, 2020, until November 24, 2020.ResultsA total of 2511 respondents completed the survey, 77.3% were females. Males were significantly smoking more than females (p < 0.0001). Smoking was significantly more common among respondents who were older than 18 years old, married, held master's and PhD degrees, and working in non‐health‐related fields (p < 0.0001). Participants who smoke were more likely to adopt an unhealthy lifestyle during the pandemic. Females who started smoking last year were 2.6‐fold more than males (p < 0.0001). We also noticed that there is a significant relationship between those who started smoking and are <18 years, living in a family consisting of seven members or more, being unemployed, having a diploma or bachelor's degree in a health‐related major, having no chronic illnesses, increasing of daily meals or night meals, almost daily sugar intake, starting to follow social media account concerning physical activity, exercising once or twice a week, and sleeping more hours per day since the beginning of the pandemic (p < 0.01).ConclusionThe results of our study showed that the lockdown had a significant impact on people's lifestyles including smoking habits. Most of our sample's smoker participants experienced a change in their smoking level mostly, an increase. While those who had a decrease in their smoking level experienced a somehow healthier lifestyle regarding nutrition and other aspects.
Second primary cancer among 217702 colorectal cancer survivors: An analysis of national German cancer registry data
Authors: Liang Linda A. , Tseng Ying‐Ju , Tanaka Luana F. , Klug Stefanie J. 
Published: July 2023

AbstractWith improvements in survival after colorectal cancer (CRC), more survivors are at risk of developing a second cancer, particularly in younger populations where CRC incidence is increasing. We estimated the incidence of second primary cancer (SPC) in CRC survivors and its potential risk factors. We identified CRC cases diagnosed between 1990 and 2011 and SPCs until 2013 from nine German cancer registries. Standardized incidence ratios (SIR) and absolute excess risk (AER) per 10 000 person‐years were calculated and were stratified by index site: colon cancer (CC) and rectal cancer (RC), age and sex. Cox regression assessed potential SPC risk factors, including primary tumor‐related therapy considering death as a competing risk. We included 217 202 primary CRC cases. SPC occurred in 18 751 CRC survivors (8.6%; median age: 69 years). Risk of cancer was significantly higher in CRC survivors than in the general population (SIR males 1.14, 95% confidence interval [CI] 1.12‐1.17, AER = 24.7; SIR females 1.20, 95% CI 1.17‐1.23, AER = 22.8). Increased risks of SPCs were observed for the digestive system, urinary system and female and male reproductive organs. CRC incidence increased in younger persons (<50 years) and SPC incidence was 4‐fold in this group (SIR males 4.51, 95% CI 4.04‐5.01, AER = 64.2; SIR females 4.03, 95% CI 3.62‐4.48, AER = 77.0). Primary tumor‐related factors associated with SPC risk were right‐sided cancer and smaller primary tumor size. Treatment and risk of SPC differed for CC (no effect) and RC (lower risk after chemotherapy). CRC survivors have excess risk of developing SPC, with particular characteristics that could guide targeted surveillance.
Contraception and intersection with HIV services in 11 high HIV burden sub‐Saharan African countries: Results from the population‐based HIV Impact Assessment cross‐sectional studies conducted from 2015 to 2018
Authors: Solmo Chelsea , Yuengling Katharine A. , Cooney Michael L. , Sachathep Karampreet , Ayton Sarah , Phillip Neena , Greenleaf Abigail , Gummerson Elizabeth , Hennesy Nora , Lulseged Sileshi , Habte Dereje , Kagashe Magreth , Rogers John H. , Kirungi Wilford , Battey Katherine , Pasipamire Munyaradzi , Namukanja Phoebe , Ndongmo Clement , Bodika Stephane , Low Andrea 
Published: July 2023

AbstractObjectiveThe United Nations' Sustainable Development Goal 3.7.1 addresses the importance of family planning. The objective of this paper is to provide information on family planning to policymakers to help increase access to contraceptive methods to women in sub‐Saharan Africa.MethodsWe analyzed data from the Population‐based HIV Impact Assessment studies conducted in 11 sub‐Saharan African countries from 2015 to 2018 to assess the relationship between HIV services and family planning. Analyses were restricted to women aged 15–49 years who reported being sexually active within the past 12 months and had data on contraceptive use.ResultsApproximately 46.4% of participants reported using any form of contraception; 93.6% of whom used modern contraceptives. Women with a positive HIV status were more likely to use contraceptives (P < 0.0001) than HIV‐negative women. Unmet need was higher among women who were confirmed to be HIV‐negative in Namibia, Uganda, and Zambia than confirmed to be positive. Women aged 15–19 years used contraception less than 40% of the time.ConclusionThis analysis highlights crucial gaps in progress among HIV‐negative and young women (aged 15–19 years). To provide access to modern contraception for all women, programs and governments need to focus on women who desire but do not have access to these family planning resources.
Hsa_circ_0003596 enhances the development of cell renal clear cell carcinoma through the miR‐502‐5p/IGF1/PI3K/AKT axis
Authors: Fang Kai , Liang Shengjie , Liu Dong , Yi Qingtong , Li Yang , Zhu Rujian 
Published: July 2023

AbstractAccumulating research findings have shown that circular RNAs (circRNAs) play an indispensable role in tumorigenesis and tumor progression. The current study aimed to explore the role and modulatory mechanism of hsa_circ_0003596 in clear cell renal cell carcinoma (ccRCC). Quantitative real‐time polymerase chain reaction was adopted to detect the expression of hsa_circ_0003596 in ccRCC tissue and cell lines. 5‐Ethynyl‐2′‐deoxyuridine, cell counting kit 8 and the colony formation assay were utilized to assess the proliferation potential of the ccRCC cells. Transwell along with wound healing assays were adopted to quantify infiltration coupled with the migration potential of the cells. The current research study found that the circRNA hsa_circ_0003596 was overexpressed in ccRCC tissue and cell lines. Further, result showed that hsa_circ_0003596 was associated with distant metastasis of renal cancer. Notably, the knockdown of hsa_circ_0003596 can lower the proliferation, infiltration and migration potential of ccRCC cells. The results of in vivo experiments found that the reduction of hsa_circ_0003596 significantly hampered the growth of tumors in mice. In addition, it was evident that hsa_circ_0003596 acts as a “molecular sponge” for miR‐502‐5p to upregulate the expression of the microRNA‐502‐5p (miR‐502‐5p) target insulin‐like growth factor 1 (IGF1R). Furthermore, it was found that the phosphatidylinositol 3‐kinase (PI3K)/AKT signaling was the downstream cascade of hsa_circ_0003596/miR‐502‐5p/IGF1R cascade, which is partly responsible for the cancer‐promoting effect. Overall, the results of the present study showed that hsa_circ_0003596 facilitated the proliferation, infiltration and migration of ccRCC through the miR‐502‐5p/IGF1R/PI3K/AKT axis. Therefore, it was evident that hsa_circ_0003596 can serve as a possible biomarker and therapeutic target against ccRCC.
One‐pot regioselective synthesis of new imidazo[4,5‐e]thiazolo[3,2‐b][1,2,4]triazines by reaction of imidazotriazines with propargyl bromide
Authors: Vinogradova Ekaterina E. , Kravchenko Angelina N. , Gazieva Galina A. 
Published: July 2023

AbstractA regioselective one‐pot method for the synthesis of imidazo[4,5‐e]thiazolo[3,2‐b][1,2,4]triazine derivatives has been developed by the reaction of imidazotriazinethiones with propargyl bromides upon treatment with potassium carbonate in methanol. The synthesis was accomplished by converting the imidazotriazinethiones into S‐propargyl derivatives followed by subsequent 5‐exo‐dig cyclization. The mechanism of the cyclization was studied using deuterium labels.
Design and simulation of T‐gate AlN/β‐Ga2O3 HEMT for DC, RF and high‐power nanoelectronics switching applications
Authors: Singh Rajan , Rao G. Purnachandra , Lenka Trupti Ranjan , Prasad S. V. S. , Boukortt Nour El. I. , Crupi Giovanni , Nguyen Hieu Pham Trung 
Published: July 2023

AbstractIn this paper, we report DC and RF analysis of a T‐gate AlN/β‐Ga2O3 high electron mobility transistors (HEMTs) by optimizing the gate‐drain distance (LGD) and two T‐gate dimensions given by the—head‐length (LHL) and the foot‐length (LFL). A two‐dimensional (2‐D) physics‐based device simulator attuned with experimental results is used to perform the analysis. The AlN/β‐Ga2O3 HEMT achieves a high two‐dimensional electron gas (2DEG) density of ~3 × 1013 cm−2, which is attributed to large spontaneous as well as piezoelectric polarization components of the 10 nm AlN thick barrier layer. 2DEG density is also numerically validated using widely used polarization model for III nitrides. It is demonstrated that a highly scaled, both lateral and vertical, device with optimized T‐gate dimensions achieves higher blocking voltage (VBR), low on‐resistance (RON), higher cut‐off frequency (fT) and higher maximum oscillation frequency (fMAX), simultaneously. Consequently, AlN/β‐Ga2O3 HEMT achieves a low specific‐on resistance (RON,sp) of 0.1 mΩ cm2 and an off‐state breakdown voltage of 904 V, which corresponds to the record power figure‐of‐merit (PFoM) of ~8172 MW/cm2. Furthermore, fT of 73 GHz and fMAX of 142 GHz are estimated. These results—low power conduction loss along with higher blocking voltage, and superior RF parameters show the potential of the analyzed device T‐gate AlN/β‐Ga2O3 HEMT for high‐power switching and RF applications.
Two‐hour indirect calorimetry measurement as a predictor of 24‐hour energy expenditure in critically ill surgical patients: A longitudinal study
Authors: Lichter Yael , Sold Oded , Angel Yoel , Nizri Eran , Gerstenhaber Fabian , Gal Oz Amir , Stavi Dekel , Nini Asaph , Singer Pierre , Goder Noam 
Published: July 2023

AbstractBackgroundMeasuring energy expenditure (EE) by indirect calorimetry (IC) has become the gold standard tool for critically ill patients to define energy targets and tailor nutrition. Debate remains as to the optimal duration of measurements or the optimal time of day in which to perform IC.MethodsIn this retrospective longitudinal study, we analyzed results of daily continuous IC in 270 mechanically ventilated, critically ill patients admitted to the surgical intensive care unit in a tertiary medical center and compared measurements performed at different hours of the day.ResultsA total of 51,448 IC hours was recorded, with an average 24‐h EE of 1523 ± 443 kcal/day. Night shift (00:00–8:00) was found to have significantly lower EE measurements (mean, 1499 ± 439 kcal/day) than afternoon (16:00–00:00; mean, 1526 ± 435 kcal/day) and morning (8:00–16:00; mean, 1539 ± 462 kcal/day) measurements (P < 0.001 for all). The bi‐hourly time frame that most closely resembled the daily mean was 18:00–19:59, with a mean of 1521 ± 433 kcal/day. Daily EE measurements of the continuous IC at days 3–7 of admission showed a trend toward a daily increase in 24‐h EE, but the difference was not statistically significant (P = 0.081).ConclusionsPeriodic measurements of EE can differ slightly when performed at various hours of the day, but the error range is small and may not necessarily have a clinical impact. When continuous IC is not available, a 2‐h EE measurement between 18:00 and 19:59 can serve as a reasonable alternative.
Raman analyses of Al and Fe/Mg‐rich clays: Challenges and possibilities for planetary missions
Authors: Demaret Lucas , Lerman Hannah N. , McHugh Melissa , Hutchinson Ian B. , Fagel Nathalie , Eppe Gauthier , Malherbe Cedric 
Published: July 2023

AbstractClays are fine‐grained rocks that form in the presence of water. Their occurrence typically depends on a combination of geological setting and geochemical conditions. The widespread and diverse clay deposits identified on Mars indicate that the planet experienced multiple episodes of water activity, especially in the early period. The characterisation of Martian clays will reveal key information on geological history, the past climatic conditions and the overall habitability of Mars. Among the analytical techniques typically utilised for such mineralogical characterisation, Raman spectroscopy will be applied for the first time during several robotic exploration missions of Mars in the 2020s. In this study, various clay‐rich samples from Westerwald, Germany were analysed to help inform mission operations and interpretation of data returned by the miniaturised Raman instruments. The samples, as verified by infrared spectroscopy, constitute kaolinites, Al‐rich smectites and Fe/Mg‐rich smectites, which are relevant to the clay mineralogy expected at Martian landing sites (Jezero crater and Oxia Planum). Despite the levels of fluorescence experienced during Raman measurements of the clay‐rich powder samples when using a 532 nm laser, the Raman signatures of phyllosilicates were identified for kaolinite and several different types of smectite (e.g. montmorillonite, nontronite, saponite) in these complex dispersions. Following these measurements, identification of various accessory minerals disseminated in the clay matrix was also achieved using the micro‐Raman system. Finally, a brief discussion concerning the analytical strategies for successful clay analyses using miniaturised Raman instruments is provided.
Comprehensive review of nickel biogeochemistry, bioavailability, and health risks in the environment
Authors: Kumar Amit , Kumar Vinod , Thakur Monika , Bakshi Palak , Koul Anju , Javaid Asma , Radziemska Maja , Pandey Vimal Chandra 
Published: July 2023

AbstractElevated nickel (Ni) content in soils and water cause a potential threat to food safety and human health. Owing to its numerous uses from common domestic items to industrial usage, it is vital to assess its bioavailability and speciation in the natural environment. In this review, the biogeochemical cycling of Ni in the natural environment and numerous aspects like dissolution, reducing‐oxidizing condition, pH, precipitation, and biological transformations have been briefly discussed. Moreover, health risks associated with Ni have been assessed based on the datasets (soil samples from diverse countries) collected from the literature, and it exerts various health perils in humans for example punctures of the nasal septum, prolonged rhinitis, and contact dermatitis instigated by the absorption of Ni‐metal dust, Ni alloys, and Ni salts on injured skin etc. The carcinogenic and non‐carcinogenic risks inferences showed that dermal interaction is the foremost method of revelation, and children are more susceptible than adults. The findings of this study will be significant for scientists, environmentalists, and policymakers in making strategic strategies for environmental protection and strategic human health management to reduce Ni pollution in the natural environment.
Warming and parasitism impair the performance of Baltic native and invasive macroalgae and their associated fauna
Authors: Bommarito Claudia , Díaz‐Morales Dakeishla M. , Guy‐Haim Tamar , Noè Simona , Delasalle Jules , Buchholz Björn , Khosravi Maral , Rilov Gil , Sures Bernd , Wahl Martin 
Published: July 2023

AbstractGlobal warming, bioinvasions, and parasitism affect single‐species performances and species interactions, substantially impacting the structure and stability of marine ecosystems. In light of accelerated global change, the information derived from studies focusing on single species and single drivers is insufficient, calling for a multi‐stressor approach under near‐natural conditions. We investigated the effects of warming (+3°C) on the performance of a benthic community composed of native and invasive macroalgae, consumers and a trematode parasite in a mesocosm setting. We also assessed the effects of warming and parasitism on the survival and growth of gastropods and mussels and the thermal dependency of trematode performance. Our findings show that warming and grazing by infected gastropods had a large detrimental effect on the invasive macroalga growth. Furthermore, the single and interactive effects of parasitism and warming were detrimental to intermediate host survival and growth, especially to large mussels. Finally, cercarial emergence positively correlated to the natural peaks of summer temperatures, while infection intensity in mussels was higher in larger individuals. Our findings suggest that grazing and warming will be detrimental to the invasive macroalga, favoring the native alga. Moreover, parasitism will enhance grazing, especially in summer, when higher temperatures trigger parasite development. However, parasite‐enhanced grazing may be buffered by higher mortality or a shift in the size of infected intermediate hosts under warming. Our findings demonstrate how complex effects of ocean warming can be on food webs and how they can be mediated by parasitism and, as a result, influence native and invasive macroalgae differently.
Reconciling the importance of meiofauna respiration for oxygen demand in muddy coastal sediments
Authors: Maciute Adele , Holovachov Oleksandr , Glud Ronnie N. , Broman Elias , Berg Peter , Nascimento Francisco J. A. , Bonaglia Stefano 
Published: July 2023

ABSTRACTMeiofauna, organisms smaller than 1 mm, are the most abundant and diverse invertebrates inhabiting the world's ocean floor but their contribution to benthic oxygen demand is still poorly constrained. This knowledge is crucial for understanding seabed respiration, global marine carbon, and oxygen cycles, which are relevant to all nutrient cycling and energy flows in the ecosystem. It is common to predict meiofauna respiration based on their biomass or volume, which are difficult to quantify, and thus meiofauna are rarely included in biogeochemistry studies. In addition, it is still unknown how well the generalized allometric relations describe all meiofauna respiration. Therefore, we used a novel approach specially developed for single meiofauna respiration measurements to derive the respiration rates of 10 meiofauna groups in two marine and one brackish coastal muddy environments under oxic and hypoxic conditions, representing natural sediment conditions. Our estimates suggest that large ostracods and juveniles of macrofauna (e.g., bivalves, trumpet worms, and priapulids) had the highest individual respiration rates. Meiofauna community as a whole contributed 3–33% to sediment oxygen uptake. However, the most important contributors to the overall sediment oxygen uptake were nematodes and foraminifera which had lower respiration rates but were highly abundant. Therefore, out of more than 22 meiofauna phyla, we recommend that nematode and foraminifera respiration, which contributes 3–30% (total 3–33%) to sediment oxygen uptake, should be taken into consideration in any estimations of benthic oxygen and carbon cycles.