bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum glycolipids mediate the relationship of urinary bisphenols with NAFLD: analysis of a population-based, cross-sectional study
Authors: Peng Jia , Du Lei-Lei , Ma Qi-Lin 
Published: January 2023

Abstract
Background
Bisphenol A (BPA) and its substitutes bisphenol S (BPS) and bisphenol F (BPF) are endocrine-disrupting chemicals widely used in consumer products, which have been proposed to induce various human diseases. In western countries, one of the most common liver diseases is non-alcoholic fatty liver disease (NAFLD). However, studies on the associations of the three bisphenols with NAFLD in human beings are scarce.

Methods
We included 960 participants aged ≥ 20 years from the NHANES 2013–16 who had available data on levels of urinary BPA, BPS and BPF. The hepatic steatosis index (HSI) > 36 was used to predict NAFLD. Logistic regression analysis and mediation effect analysis were used to evaluate the associations among bisphenols, glycolipid-related markers and NAFLD.

Results
A total of 540 individuals (56.3%) were diagnosed with NAFLD, who had higher concentrations of BPA and BPS but not BPF than those without NAFLD. An increasing trend in NAFLD risks and HSI levels was observed among BPA and BPS tertiles (p for trend < 0.05). After adjustment for confounders, elevated levels of BPA or BPS but not BPF were significantly associated with NAFLD. The odds ratio for NAFLD was 1.581 (95% confidence intervals [CI]: 1.1–2.274, p = 0.013) comparing the highest with the lowest tertile of BPA and 1.799 (95%CI: 1.2462.597, p = 0.002) for BPS. Mediation effect analysis indicated that serum high-density lipoprotein cholesterol and glucose had a mediating effect on the relationships between bisphenols and NAFLD.

Conclusions
The present study showed that high exposure levels of BPA and BPS increased NAFLD incidence, which might be mediated through regulating glycolipids metabolism. Further studies on the role of bisphenols in NAFLD are warranted.
A snake venom-analog peptide that inhibits SARS-CoV-2 and papain-like protease displays antithrombotic activity in mice arterial thrombosis model, without interfering with bleeding time
Authors: Nogueira Ruben Siedlarczyk , Salu Bruno Ramos , Nardelli Vinícius Goulart , Bonturi Camila Ramalho , Pereira Marina Rodrigues , de Abreu Maffei Francisco Humberto , Cilli Eduardo Maffud , Oliva Maria Luiza Vilela 
Published: January 2023

Abstract
Background
(p-BthTX-I)2 K, a dimeric analog peptide derived from the C-terminal region of phospholipase A2-like bothropstoxin-I (p-BthTX-I), is resistant to plasma proteolysis and inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains with weak cytotoxic effects. Complications of SARS-CoV-2 infection include vascular problems and increased risk of thrombosis; therefore, studies to identify new drugs for treating SARS-CoV-2 infections that also inhibit thrombosis and minimize the risk of bleeding are required.

Objectives
To determine whether (p-BthTX-I)2 K affects the hemostatic system.

Methods
Platelet aggregation was induced by collagen, arachidonic acid, and adenosine diphosphate (ADP) in the Chronolog Lumi-aggregometer. The coagulation activity was evaluated by determining activated partial thromboplastin clotting time (aPTT) and prothrombin time (PT) with (p-BthTX-I)2 K (5.0–434.5 µg) or 0.9% NaCl. Arterial thrombosis was induced with a 540 nm laser and 3.5–20 mg kg− 1 Rose Bengal in the carotid artery of male C57BL/6J mice using (p-BthTX-I)2 K. Bleeding time was determined in mouse tails immersed in saline at 37 °C after (p-BthTX-I)2 K (4.0 mg/kg and 8.0 mg/kg) or saline administration.

Results
(p-BthTX-I)2 K prolonged the aPTT and PT by blocking kallikrein and FXa-like activities. Moreover, (p-BthTX-I)2 K inhibited ADP-, collagen-, and arachidonic acid-induced platelet aggregation in a dose-dependent manner. Further, low concentrations of (p-BthTX-I)2 K extended the time to artery occlusion by the formed thrombus. However, (p-BthTX-I)2 K did not prolong the bleeding time in the mouse model of arterial thrombosis.

Conclusion
These results demonstrate the antithrombotic activity of the peptide (p-BthTX-I)2 K possibly by kallikrein inhibition, suggesting its strong biotechnological potential.
Future directions for reproductive coercion and abuse research
Authors: Grace Karen Trister , Miller Elizabeth 
Published: January 2023

Abstract
Background
Reproductive coercion and abuse (RCA) is a form of intimate partner violence (IPV) in which people with the capacity for pregnancy experience coercive behaviors that threaten their reproductive autonomy. Behaviors that constitute RCA include contraceptive control/sabotage, pregnancy pressure, and controlling the outcome of a pregnancy.

Summary
Several areas of RCA study have emerged: associations with IPV, health outcomes resulting from RCA, and demographic and contextual factors associated with experiencing RCA. Current research in these areas is summarized and placed in a global context, including sexual and gender minority groups, use of RCA (exploring perpetration), RCA interventions, RCA in women with disabilities, and the question of whether people assigned male at birth can be RCA victims.

Conclusion
Areas for future exploration include evolving interpretations of pregnancy intention in the setting of fewer options for abortion, RCA in people with disabilities and multiple levels of marginalization, including sexual and gender minorities; intersections between RCA and economic abuse in the context of efforts at economic justice; and community-centered approaches to intervention and prevention.
The effectiveness of a motivational text-messaging program for smoking cessation after coronary angioplasty: a quasi-experimental study
Authors: Mobaraki Mohammad Sadegh , Khademian Zahra , Shirazi Fatemeh 
Published: January 2023

AbstractObjectiveSmoking is an important risk factor of coronary artery stenosis after angioplasty. Therefore, this investigation aimed to determine the effectiveness of a motivational text-messaging program for smoking cessation after coronary angioplasty. This quasi-experimental study was conducted on 100 patients after angioplasty. The patients were divided randomly into two intervention and control groups. The intervention group received 32 text messages about smoking cessation for 2 months. The control group received only routine training. The primary and secondary outcomes were success and self-efficacy in quitting smoking cigarettes, respectively. Both groups filled out the related questionnaires before and after the intervention. The data were analyzed using SPSS software version 22 and Chi-square tests, independent t-test, and paired t-test. P < 0.05 was considered significant.ResultsSuccess in quitting cigarette smoking was significantly higher in the intervention group (n = 29, 61.7%) compared to the control group (n = 2, 4.3%) (p < 0.001). Moreover, after the intervention, the mean score of self-efficacy in the intervention group (11.01 ± 44.75) was significantly higher than the control group (6.51 ± 3.11) and also higher than before the intervention (5.51 ± 2.44) (P˂0.001). The motivational text-messaging program can improve self-efficacy and success in smoking cessation in patients after coronary angioplasty.
Analysis of multipoint impulsive problem of fractional-order differential equations
Authors: Shah Kamal , Abdalla Bahaaeldin , Abdeljawad Thabet , Gul Rozi 
Published: January 2023

AbstractThis manuscript is related to establishing appropriate results for the existence and uniqueness of solutions to a class of nonlinear impulsive implicit fractional-order differential equations (FODEs). It is remarkable that impulsive differential equations have attracted great popularity due to various important applications in the mathematical modeling of real-world phenomena/processes, particularly in biological or biomedical engineering domains as well as in control theory. The mentioned problem is considered under four-point nonlocal boundary conditions and the derivative is taken in the Caputo sense. Our results are based on fixed-point theorems due to Banach and Schaefer. To justify our results, two suitable examples are given.
“The system always undermined what I was trying to do as an individual”: identifying opportunities to improve the delivery of opioid use services for youth from the perspective of service providers in four communities across British Columbia, Canada
Authors: Marchand Kirsten , Turuba Roxanne , Katan Christina , Fogarty Oonagh , Fairbank Jill , Tallon Corinne , Mathias Steve , Barbic Skye 
Published: January 2023

AbstractBackgroundSubstance use among youth is a longstanding global health concern that has dramatically risen in the era of highly toxic and unregulated drugs, including opioids. It is crucial to ensure that youth using unregulated opioids have access to evidence-based interventions, and yet, youth encounter critical gaps in the quality of such interventions. This study aims to address these gaps by identifying opportunities to improve the quality of opioid use services from the perspective of service providers, a perspective that has received scant attention.MethodsThis community-based participatory study was conducted in four communities in British Columbia (Canada), a province that declared a public health overdose emergency in 2016. Human-centered co-design workshops were held to understand service providers’ (n = 41) experiences, needs, and ideas for improving the quality of youth opioid use services/treatments in their community. Multi-site qualitative analysis was used to develop overarching experiences and needs themes that were further contextualized in each local community. A blended deductive and inductive thematic analysis was used to analyze the ideas data.ResultsThree overarching themes were identified, reflecting service providers’ goals to respond to youth in a timely and developmentally appropriate manner. However, this was significantly limited by organizational and systems-level barriers, revealing service providers’ priorities for intra- and inter-organizational support and collaboration and systems-level innovation. Across communities, service providers identified 209 individual ideas to address these prioritized needs and improve the quality of youth opioid use services/treatments.ConclusionThese themes demonstrate a multi-level tension between macro-level systems and the meso-level organization of youth opioid use services, which undermine the quality of individual-level care service providers can deliver. These findings underscore the need for a coordinated multi-level response, such as developing youth-specific standards (macro-level), increasing inter-organizational activities and collaboration (meso-level), and creating programs that are specific to youths’ needs (micro-level).
Nutritional intake of sport undergraduates in Sabaragamuwa University of Sri Lanka
Authors: Rupasinghe W. A. W. S. , Perera T. S. H. , Silva K. D. R. R. , Samita S. , Wickramaratne M. Nirmali 
Published: January 2023

Abstract
Background
Nutritional intake plays an important role in determining energy availability which is vital to health, wellbeing, and sports performance in an active population. This research assessed the sports undergraduates' nutritional intake compared to the Dietary Guidelines for Americans and nutrition goals provided by WHO.

Methods
This study is a quantitative, cross-sectional descriptive study. One hundred and one (n = 101) sports undergraduates aged between 20 to 23 years were recruited and the nutrient intake was assessed using the three-day food diary method and quantified the macro and micronutrients by the food composition database. One sample t-test was performed to compare the mean nutrient intakes with the lowest recommendation values.

Results
Though most undergraduates were able to meet the dietary requirements in carbohydrates, they were deficient in their protein intake and exceeded in fats intake. Further, both male and female students were deficient in their daily energy intake (1723 kcal, 1607 kcal) and dietary fiber intake (8 g, 11 g). The saturated fat intake was met by all students while 20% of males and 21% of females exceeded the recommendations (< 10%). The micronutrient intake of vitamins such as C, B1, B2, B9, and B12 and minerals such as Calcium, Magnesium, and Potassium, were significantly below the recommendations (p < 0.05) except for vitamin B3 niacin.

Conclusions
Providing a nutritionally valuable meal is essentially required to maintain both physical and mental fitness. Our results revealed that the Sri Lankan sport science undergraduates do not have an adequate daily dietary intake of energy, proteins, calcium, magnesium, potassium, and vitamins such as C, B1, B2, B9, and B12.
The impact of domestic violence: a prospective forensic study in the northeastern region of Algeria (Annaba)
Authors: Mellouki Y. , Sellami L. , Zerairia Y. , Saker L. , Belkhadja N. , Zetili H. , Guehria F. , Kaious F. , Bensaaida M. , Mira A. H. 
Published: January 2023

Abstract
Background
Violence against women is a global problem affecting different social and economic classes. The present study aimed to identify the impact of domestic violence on the health status of women abused by their intimate partner.

Methods
This is a cross-sectional descriptive study of a sample of women who were examined at the forensic exploration unit of Annaba Hospital over a period of 3 months (first quarter of 2018). In all, 200 women were recruited among those who had been abused by the intimate partner.

Results
One in ten women who consulted was a victim of domestic violence (9.36%). The average age was 33.91+/−9.02 years, with extremes from 19 to 65 years. There were multiple consequences, including physical injuries (bruises, fractures), many sequelae (neurosensory and functional deficits), and acute stress and anxiety disorders requiring appropriate care and social consequences (lack of resources, divorce). Forty percent of the interviewed victims had a general comorbidity, three quarters of whom had a worsening of their previous pathology. All forms of violence were present with varying frequencies, especially psychological violence with an extremely high frequency and sexual violence of remarkable severity. Many negative effects were identified; an association of suicide attempts and sexual violence (P = 0.0020) was rated.

Conclusions
The impact of this form of abuse is considerable and concerns mental, physical, and social health. We have to anticipate and raise the awareness of care providers of its consequences.
Electronic Consent at US Cancer Centers: A Survey of Practices, Challenges, and Opportunities
Authors: Chimonas Susan , Lipitz-Snyderman Allison , Gaffney Kemi , Kuperman Gilad J. 
Published: January 2023

PURPOSE Digital technologies create opportunities for improving consenting processes in cancer care and research. Yet, little is known about the prevalence of electronic consenting, or e-consent, at US cancer care institutions. METHODS We surveyed institutions in the National Comprehensive Cancer Network about their capabilities for clinical, research, and administrative e-consents; technologies used; telemedicine consents; multilingual support; evaluations; and opportunities and challenges in moving from paper-based to electronic processes. Responses were summarized across responding institutions. RESULTS Twenty-five institutions completed the survey (81% response rate). Respondents were from all census regions and included freestanding and matrix cancer centers. Twenty (80%) had e-consent capabilities, with variability in the extent of adoption: One (5%) had implemented e-consent for all clinical, research, and administrative needs while 19 (95%) had a mix of paper and electronic consenting. Among those with e-consent capabilities, the majority (14 of 20, 70%) were using features embedded in their electronic health record. Most had a combination of paper and e-consenting for clinical purposes (18, 72%). About two-thirds relied entirely on paper for research consents (16, 64%) but had at least some electronic processes for administrative consents (15, 60%). Obstacles to e-consenting included challenges with procuring or maintaining hardware, content management, workflow integration, and digital literacy of patients. Successes included positive user experiences, workflow improvements, and better record-keeping. Only two of 20 (10%) respondents with e-consent capabilities had evaluated the impact of automating consent processes. CONCLUSION E-consent was prevalent in our sample, with 80% of institutions reporting at least some capabilities. Further progress is needed for the benefits of e-consenting to be realized broadly.
Estimation of interfacial-layer thickness from voltage-dependent domain switching times in LiNbO3 single-crystal domain wall memory
Authors: Zhuang Xiao , Jiang An Quang 
Published: January 2023

Abstract
Conducting domain walls created through the local domain 180° reversal within LiNbO3 mesa-like cells fabricated at the surface of a single-crystal LiNbO3 thin film have enabled ferroelectric domain wall memories, transistors, and sensors, where volatile switching in the domains within the interfacial layers near two side electrodes can rectify diode-like wall conduction under an applied voltage higher than an onset voltage. The diodes at interfaces not only can perform NOT, NAND, and NOR gate logic functions for in-memory computing, but can also work as embedded selectors for the fabrication of crossbar arrays of the memories in adjustable onset voltages that are proportional to the thicknesses of interfacial layers. Here, we develop a method to estimate the interfacial-layer thickness through the measurements of voltage-dependent domain switching times across two interfacial layers and an entire memory cell, respectively. Both dependences can be fitted according to the Merz law using an identical activation field from which we derived the equivalent electrical thickness of the interfacial layer. This non-destructive estimation paves the way to tailoring onset voltages of the diodes through the regulation of interfacial-layer thicknesses within various domain wall nanodevices.
Neuropeptide Y Promotes mTORC1 to Regulate Chondrocyte Proliferation and Hypertrophy
Authors: Kang Xiaomin , Ma Xiao , Li Huixia , Jin Xinxin , Gao Xin , Feng Dongxu , Wu Shufang 
Published: January 2023

Abstract
Peripheral neuropeptide Y (NPY) has been reported to regulate bone metabolism and homeostasis; however, its potential roles in growth plate chondrogenesis remain unclear. Here, we found that NPY expression decreased during chondrocyte differentiation in vitro and in vivo. NPY was required for chondrocyte proliferation; in contrast, knockdown of NPY facilitated chondrocyte hypertrophic differentiation. Administration of recombinant NPY in rat chondrocytes and metatarsal bones uncoupled normal proliferation and hypertrophic differentiation during chondrogenesis and thereby inhibited growth plate chondrogenesis and longitudinal bone growth. Remarkably, NPY activated the mTORC1 pathway in chondrocytes, whereas attenuation of mTORC1 activity by administration of rapamycin in vitro partially abrogated NPY-mediated effects on chondrocyte proliferation and hypertrophic differentiation. In addition, a combination of Y2R antagonist but not Y1R antagonist with NPY abolished NPY-mediated inhibition of metatarsal growth and growth plate chondrogenesis. Mechanistically, NPY activated Erk1/2 by NPY2R, then phosphorylated ERK1/2 activated mTORC1 to initiate PTHrP expression, which in turn promoted chondrocyte proliferation and inhibited chondrocyte hypertrophic differentiation. In conclusion, our data identified NPY as a crucial regulator of chondrogenesis and may provide a promising therapeutic strategy for skeletal diseases.
Enkephalin-δ Opioid Receptor Signaling Mediates Glucoprivic Suppression of LH Pulse and Gluconeogenesis in Female Rats
Authors: Tsuchida Hitomi , Nonogaki Miku , Takizawa Marina , Inoue Naoko , Uenoyama Yoshihisa , Tsukamura Hiroko 
Published: January 2023

Abstract
Energy availability is an important regulator of reproductive function at various reproductive phases in mammals. Glucoprivation induced by 2-deoxy-D-glucose (2DG), an inhibitor of glucose utilization, as an experimental model of malnutrition suppresses the pulsatile release of GnRH/LH and induces gluconeogenesis. The present study was performed with the aim of examining whether enkephalin-δ-opioid receptor (DOR) signaling mediates the suppression of pulsatile GnRH/LH release and gluconeogenesis during malnutrition. The administration of naltrindole hydrochloride (NTI), a selective DOR antagonist, into the third ventricle blocked the suppression of LH pulses and part of gluconeogenesis induced by IV 2DG administration in ovariectomized rats treated with a negative feedback level of estradiol-17 β (OVX + low E2). The IV 2DG administration significantly increased the number of Penk (enkephalin gene)-positive cells coexpressing fos (neuronal activation marker gene) in the paraventricular nucleus (PVN), but not in the arcuate nucleus (ARC) in OVX + low E2 rats. Furthermore, double in situ hybridization for Penk/Pdyn (dynorphin gene) in the PVN revealed that approximately 35% of the PVN Penk-expressing cells coexpressed Pdyn. Double in situ hybridization for Penk/Crh (corticotropin-releasing hormone gene) in the PVN and Penk/Kiss1 (kisspeptin gene) in the ARC revealed that few Penk-expressing cells coexpressed Crh and Kiss1. Taken together, these results suggest that central enkephalin-DOR signaling mediates the suppression of pulsatile LH release during malnutrition. Moreover, the current study suggests that central enkephalin-DOR signaling is also involved in gluconeogenesis during malnutrition in female rats.
Τα graffiti ως μοχλός κριτικής συνειδητοποίησης: μια σύγχρονη εφαρμογή του παιδαγωγικού προγράμματος του Freire
Authors: Mega Georgia 
Published: January 2023

Το περιεχόμενο του άρθρου πραγματεύεται το επίκαιρο της παιδαγωγικής προσέγγισης του Paulo Freire. Όπως είναι γνωστό, ο Βραζιλιάνος Παιδαγωγός εισήγαγε για την εποχή του μια πρωτοπόρα προσέγγιση στη μάθηση και τη διδασκαλία που αφυπνίζει πολιτικά, διεγείρει κοινωνικά και απελευθερώνει συνειδησιακά, υπό συνθήκες στοχαστικού διαλόγου. Μέσα από τα κατά παραγγελία σκίτσα που ο ίδιος ο Freire ανέθετε σε σημαντικούς καλλιτέχνες της εποχής του, όπως ο Francisco Brennand, οι ενήλικοι μαθητές σταδιακά, όχι μόνο εξοικειώνονταν στη χρήση βασικού λεξιλογίου, την ανάγνωση και τη γραφή, αλλά, επιπλέον, μέσα από τη διεργασία της κωδικοποίησης και της αποκωδικοποίησης συνειδητοποιούσαν την πηγή της καταπίεσής τους και τα ενδεχόμενα δικαιώματά τους.
Μπορεί να συμβεί το ίδιο και σήμερα; Είναι δυνατόν δημόσια έργα τέχνης να παίξουν αφυπνιστικό ρόλο στη συνείδηση του σύγχρονου πολίτη και πώς; Αυτός ο προβληματισμός αναπτύσσεται στο πλαίσιο του παρόντος άρθρου, λαμβάνοντας υπόψη τη διεργασία της κωδικοποίησης και αποκωδικοποίησης όπως παραδοσιακά ορίζεται από τον Freire (Freire 1974).
Το εικαστικό έναυσμα για την ενεργοποίηση του στοχαστικού διαλόγου στην παρούσα κοινωνικο-πολιτική φάση της ανθρωπότητας αποτελούν σύγχρονα έργα τέχνης- όπως τα graffiti- τα οποία αντανακλούν μια σιωπηρή διαμαρτυρία για τα τεκτενώμενα, προσβάσιμη σε όλους, αφού αποτελούν πλέον αναπόσπαστο μέρος του αστικού τοπίου των μεγαλουπόλεων ανά τον κόσμο. Από την ευρεία γκάμα των graffiti επιλέχθηκε για πρακτική εφαρμογή των αρχών του Freire το έργο του εικαστικού STMTS. Οι δυνατές μεταφορές τους προκαλούν τον παρατηρητή να στοχαστεί για την πραγματικότητα που βιώνει στον σύγχρονο κόσμο.