bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nobel laureates in Physics, Chemistry and Medicine: relation between research funding and citations
Authors: Coccia Mario 
Published: May 2023

Abstract

One of the vital problems in scientometrics is to explore the factors that affect the growth of citations in publications and in general the diffusion of knowledge in science and society. The goal of this study is to analyze the relation between funded and unfunded papers and citations of Nobel Laureates in physics, chemistry and medicine over 2019-2020 period and the same relation in these research fields as a whole to clarify the scientific development. Original results here reveal that in chemistry and medicine, funded papers of Nobel Laureates have higher citations than unfunded papers, vice versa in physics that has high citations in unfunded papers. Instead, when overall research fields of physics, chemistry and medicine are analyzed, funded papers have a higher level of citations than unfunded, with a higher scaling factor in chemistry and medicine. General properties of this study are that: a) funded articles receive more citations than unfunded papers in research fields of physics, chemistry and medicine, generating a high Matthew effect given by a higher accumulation and growth of citations with the growth of papers, b) funding increases the citations of articles in fields oriented to applied research (such as, chemistry and medicine) more than fields oriented to basic research (physics). Overall, then, results here can explain some characteristics of scientific dynamics, showing the critical role of funding to foster citations and diffusion of knowledge, also having potential commercial implications in applied research. Results here can be provide useful information to understand drivers of the scientific development in basic and applied research fields to better allocate financial resources in research fields directed to support a positive scientific and societal impact.
Association study of FSHR G-29A, 2039A&gt;G, ESR1 (PvuII) showing incident rates of genotypic combinations and it`s correlations with serum hormone FSH, LH, Estradiol levels in patients with primary amenorrhea
Authors: Chauhan Pooja , Biswas Sudipto , Rai Amit Kumar 
Published: May 2023

Abstract
Background Primary amenorrhea is a condition of abnormal menstrual cycle that results into different reproductive diseases. Several functional polymorphisms have been identified in genes that regulate the hypothalamus-pituitary-gonad axis which controls ovarian function. The objective of present study was to analyze the role of genetic variants of HPG axis genes (FSHR G-29A, 2039A > G and ESR1 (PvuII)) on the severity of clinical features of amenorrhea and disease susceptibility.Methods In this study, the allelic, genotype and haplotype frequency distributions of three SNPs in the FSHR and ESR1 gene were analyzed in 101 women with primary amenorrhea, and 122 age- and ethnically-matched control individuals. FSHR and ESR1 genotyping were done by Polymerase chain reaction-Restriction length polymorphism and Amplification-Refractory Mutation System method. Genotype distributions were compared between patients and controls. The distribution of the polymorphisms was confirmed by Hardy-Weinberg equilibrium test.Result A significant increase in luteinizing hormone level in GG genotype of FSHR 2039G > A was observed. However, allelic, genotype and haplotype frequencies of three polymorphisms considering the primary amenorrhea did not differ statistically. Genetic combination analysis also suggests no association in studied SNPs between patients and controls. Limited linkage disequilibrium was noted among FSHR G-29A and 2039A > G.Conclusion The FSHR 2039G > A polymorphism modulates LH serum levels in primary amenorrhea patients. These findings highlight the importance to pay attention to the association studies of genetic variations associated with clinical-endocrine parameters. However, these findings need to be confirmed in different types of populations.
∈ - varepsilon-regularity criteria and the number of singular points for the 3D simplified Ericksen-Leslie system
Authors: Zuo Zhongbao 
Published: May 2023

Abstract
In this paper, we present a new regularity criteria for suitable weak solutions to the 3D simplified Ericksen-Leslie system. Moreover, under the condition \|\mathbf{u}\|_{L^{q,\infty}_tL^p_x(Q_r(z_0))}+ \|\nabla\mathbf{d}\|_{L^{q,\infty}_tL^p_x(Q_r(z_0))}=K<\infty,~ (\frac{3}{p}+\frac{2}{q}=1~\rm{and}~3
Effect of faceting on olivine wetting properties
Authors: Huang Yongsheng , Nakatani Takayuki , Sawa Sando , Wu Guoji , Nakamura Michihiko , McCammon Catherine 
Published: May 2023

Abstract
Grain-scale pore geometry primarily controls the fluid distribution in rocks, affecting material transport and geophysical response. The dihedral angle (θ) in the olivine-fluid system is a key parameter determining pore fluid geometry in mantle wedges. In the system, curved and faceted olivine-fluid interfaces define θ, resulting in faceted-faceted (FF), faceted-curved (FC), and curved-curved (CC) angles. The effect of faceting on θ under various pressure and temperature (P-T) conditions and fluid compositions, however, has not been constrained, and mineralogical understanding remains unresolved. This study evaluated facet-bearing θ and their proportions in olivine-multicomponent aqueous fluid systems. Our results show that 1/3 of olivine-fluid θ are facet-bearing angles, regardless of the P-T conditions and fluid composition. Faceting produces larger dihedral angles than CC angles. The grain boundary plane (GBP) distribution reveals that the GBPs of faceted interfaces at triple junctions have low Miller index faces ({100}, {010}, and {101}). The misorientation angle/axis distributions of adjacent grain pairs are in accord with a theoretical distribution of random olivine aggregate. Moreover, the calculation of the FF angles for adjacent grain pairs with low Miller index GBPs reproduces measured angle values based on the olivine crystal habit. Therefore, our study suggests that the FF angle is strongly affected by olivine crystallography. The presence of faceting increases θ and a critical fluid fraction (φc) for percolation, lowering permeability. In the mantle wedge, where olivine crystallographic preferred orientation (CPO) is expected owing to corner flow, increasing the FF angle proportion with associated changes in fluid pore morphology will lead to permeability anisotropy, and controlling the direction of the fluid flow, and it will result in geophysical anomalies such as seismic wave attenuation and high electrical conductivity.
Percepção de valor do suporte em redes de microfranquias: análise da teoria de Honeymoon
Authors: Ragazzi Isaac Victor , Alves Bezerra Adenilson , Lucas de Resende Melo Pedro 
Published: May 2023

O modelo de microfranquias tem sido utilizado como opção de negócio por investidores que têm baixa capacidade financeira. Academicamente, há um prevalecimento de pesquisas sobre microfranquias relacionadas às questões socioeconômicas. Entretanto, este estudo tem como proposito preencher uma lacuna acadêmica latente ao se analisar aspectos de gerenciamento do suporte ao franqueado. Assim, temos como objetivo verificar se há relação entre o tempo de franqueamento em redes de microfranquias e a percepção do microfranqueado em relação ao suporte que é prestador pelo franqueador. Os aspectos metodológicos envolveram a coleta de dados por meio de uma survey junto a 222 microfranqueados. Foram analisados como variável dependente, o tempo de franqueamento, e como variável independente o suporte ao franqueado, representado nos constructos (1) Treinamento; (2) Prospecção e Instalação; e (3) Assessoria Jurídica e Financeira. Utilizou-se o método de análise de regressão linear, que mostrou por meio dos resultados não haver relação entre o tempo de franqueamento e a percepção de valor do suporte pelo microfranqueado. Assim, as contribuições teóricas preenchem lacunas aos estudos de microfranquias, a teoria de honeymoon e a teoria de recursos.
Matrix Metalloproteinase-9, Neuron-specific Enolase, S100 B and Tau Protein
Levels in the Patients with Carbon monoxide Poisoning
Authors: Can Basri , Zengin Suat , Hakan Eren Şevki , Boğan Mustafa , Sabak Mustafa , Gülen Bedia , Ulusal Hasan , Mustafa Sunar Mehmet , Esat Karaduman Muhammet , Taysı Seyithan 
Published: May 2023

Background:
S100B, NSE, MMP-9, and Tau protein levels increase in cases causing hypoxic cell damage. The diagnosis of the severity of carbon monoxide (CO) poisoning in the early period of these parameters was studied.

Material and Method:
COHb level measurement was made using a signal capture CO-pulse oximeter (Masimo's SET Rainbow, Masimo's Co, USA) at the first admission of the patients. Then, COHb levels were confirmed by arterial blood gas(ABG) analysis. The patients were divided into two groups as mild and moderate-severe, according to their Glasgow coma scores (GCS) [Mild (14–15); Moderate (9–13) or Severe (3–8)]. The control group was composed of 16 healthy and non-smoking volunteers.

Results:
The serum S100B protein and MMP-9 values at 0 hr of admission in the hospital and 3hr of treatment were not significantly different in the patient group as compared to the control group. Tau protein levels were significantly higher in the patient group at 0 and 3 hours (p> 0.05) as compared to healthy person.

Conclusion:
There was no relationship between CO poisoning and MMP-9 and S100B protein levels. NSE and Tau protein were significantly higher in the patient group than the control group. Tau protein may be more useful marker as compared to neuron-specific enolase.
The Prospect of Genomic, Transcriptomic, Epigenetic and Metabolomic
Biomarkers for The Personalized Prevention of Type 2 Diabetes and
Cardiovascular Diseases
Authors: Zeljkovic Aleksandra , Mihajlovic Marija , Vujcic Sanja , Guzonjic Azra , Munjas Jelena , Stefanovic Aleksandra , Kotur-Stevuljevic Jelena , Rizzo Manfredi , Bogavac-Stanojevic Natasa , Gagic Jelena , Kostadinovic Jelena , Vekic Jelena 
Published: May 2023

Abstract:
Cardiometabolic diseases, such as type 2 diabetes mellitus (DM) and cardiovascular disease
(CVD), are a great health concern. The strategies aimed to increase awareness and prevention, in conjunction
with timely diagnosis and optimal management of these conditions, represent the main lines of
action to improve life expectancy and quality. In recent years, the introduction of innovative therapies
for the treatment of DM and CVD has provided new hope for high-risk patients. Yet, the implementation
of preventive measures in achieving cardiometabolic health is far from successful and requires further
improvement. The development of cardiometabolic disorders is a complex, multifactorial process
involving several metabolic pathways as well as genetic and environmental factors. Decreasing cumulative
exposure during the entire life course and timely recognition and targeting of potential riskenhancing
factors could pave the way toward more successful prevention of cardiometabolic disorders.
Nowadays, in the era of “omics” technologies, it is possible to identify novel biomarkers and therapeutic
targets, which offers the possibility to apply an individualized approach for each patient. This review
will discuss potential applications of genomic, transcriptomic, epigenetic and metabolomic biomarkers
for the personalized prevention of cardiometabolic diseases.
Green Approach Toward Triazole Forming Reactions for Developing
Anticancer Drugs
Authors: Rastogi Shiva K. , Ciliberto Veronica C. , Trevino Monica Z. , Campbell Brooke A. , Brittain William J. 
Published: May 2023

Abstract:
Compounds containing triazole have many significant applications in the dye and ink industry, corrosion inhibitors, polymers, and pharmaceutical industries. These compounds possess many antimicrobial, antioxidant, anticancer, antiviral, anti-HIV, antitubercular, and anticancer ac-tivities. Several synthetic methods have been reported for reducing time, minimizing synthetic steps, and utilizing less hazardous and toxic solvents and reagents to improve the yield of triazoles and their analogues synthesis. Among the improvement in methods, green approaches towards tri-azole forming biologically active compounds, especially anticancer compounds, would be very important for pharmaceutical industries as well as global research community. In this article, we have reviewed the last five years of green chemistry approaches on click reaction between alkyl azide and alkynes to install 1,2,3-triazole moiety in natural products and synthetic drug-like mole-cules, such as in colchicine, flavanone cardanol, bisphosphonates, thiabendazoles, piperazine, prostanoid, flavonoid, quinoxalines, C-azanucleoside, dibenzylamine, and aryl-azotriazole. The cytotoxicity of triazole hybrid analogues was evaluated against a panel of cancer cell lines, includ-ing multidrug-resistant cell lines.
Synthesis, Molecular Modeling and Biological Evaluation of Novel
Trifluoromethyl Benzamides as Promising CETP Inhibitors
Authors: Abu Khalaf Reema , Abusaad Amani , Al-Nawaiseh Bara'a , Sabbah Dima , Albadawi Ghadeer 
Published: May 2023

Background:
Hyperlipidemia is considered a major risk factor for the progress of atherosclerosis.

Objective:
Cholesteryl ester transfer protein (CETP) facilitates the relocation of cholesterol esters
from HDL to LDL. CETP inhibition produces higher HDL and lower LDL levels.

Methods:
Synthesis of nine benzylamino benzamides 8a-8f and 9a-9c was performed.

Results:
In vitro biological study displayed potential CETP inhibitory activity, where compound
9c had the best activity with an IC50 of 1.03 µM. Induced-fit docking demonstrated that 8a-8f and
9a-9c accommodated the CETP active site and hydrophobic interaction predominated ligand/
CETP complex formation.

Conclusion:
Pharmacophore mapping showed that this scaffold endorsed CETP inhibitors features and consequently elaborated the high CETP binding affinity.
Review of Carbon Nanotube Field Effect Transistor for Nanoscale Regime
Authors: Maqbool Mehwish , Sharma Vijay Kumar 
Published: May 2023

Background:
The need for high performance, small size, low delay, low power consumption,
and long battery backup of portable systems is increasing with the advancement of
technology. Many features of portable systems can be improved using scaling methods. In the
scaling process, reducing the size of devices causes serious difficulties, including the short
channel effect (SCE) and leakage current, which degenerates the characteristics of the systems.

Objective:
In this review paper, a trending carbon nanotube field effect transistor (CNTFET)
technology is discussed in detail. CNTFET can replace the conventional metal oxide semiconductor
field effect transistor (MOSFET) technology to overcome the SCE problems in the nanoscale
regime and also meet the requirements of portable systems.

Methods:
The CNTFET is an extremely good nanoscale technology due to its one-dimension
band structure, high transconductance, high electron mobility, superior control over channel
formation, and better threshold voltage. This technology is used to construct high-performance
and low-power circuits by replacing the MOSFET technology. CNTFET in comparison to
MOSFET takes the carbon nanotube (CNT) as a channel region.

Results:
The value of threshold voltage in CNTFET changes with the diameter of CNT. The
threshold voltage of the devices controls many parameters at the circuit-level design. Hence, the
detailed operation and the characteristics of CNTFET devices are presented in this review paper.
The existing CNTFET-based ternary full adder (TFA) circuits are also described in this review
paper for the performance evaluation of different parameters.

Conclusion:
CNTFET technology is the possible solution for the SCE in the nanoscale regime
and is capable to design efficient logic circuits. The circuits using the CNTFET technology can
provide better performance and various advantages, including fast speed, small area, and low
power consumption, in comparison to the MOSFET circuits. Thus, CNTFET technology is the
best choice for circuit designs at the nanoscale.
Exosomal-microRNAs Improve Islet Cell Survival and Function In Islet
Transplantation
Authors: Minhua Qiu , Bingzheng Feng , Zhiran Xu , Yingying Zhang , Yuwei Yang , Ting Zhang , Jibing Chen , Hongjun Gao 
Published: May 2023

Abstract:
Exosomal-microRNAs (Exo-miRNAs) are key regulators of islet cell function, including insulin
expression, processing, and secretion. Exo-miRNAs have a significant impact on the outcomes of islet
transplantation as biomarkers for evaluating islet cell function and survival. Furthermore, they have been
linked to vascular remodeling and immune regulation following islet transplantation. Mesenchymal stem
cell-derived exosomes have been shown in preliminary studies to improve islet cell viability and function
when injected or transplanted into mice. Overall, Exo-miRNAs have emerged as novel agents for improving
islet transplantation success rates. The role of islet-derived Exo-miRNAs and mesenchymal stem
cells-derived Exo-miRNAs as biomarkers and immunomodulators in islet regeneration, as well as their
role in improving islet cell viability and function in islet transplantation, are discussed in this review.
Novel Arcyriaflavin-A Derivatives as PIM Kinase Inhibitors for Treating Cancer
Authors: De Surya K. 
Published: May 2023

Abstract:
The present application reports a series of novel Arcyriaflavin-A derivatives as PIM kinase inhibitors for the
effective treatment of cancer. The application also describes the synthesis of compounds in detail, use, pharmaceutical
composition, pharmaceutically acceptable salts, and treatment.
An Integrated Approach for Analysis of Electronic Health Records Using
Blockchain and Deep Learning
Authors: Singhal Pooja , Gupta Shelly , Deepak  , Singh Jagendra 
Published: May 2023

Abstract:
Blockchain is used to assess health records digitally, preserving the security and immutability of the records. The goal of this study is to make it easier for patients to access their medical records and to send them alert messages about important dates for their check-ups, healthy diet, and appointments. To achieve the above-mentioned objective, an integrated approach using Blockchain and Deep learning is initiated. The first approach is Hyperledger Fabric in Blockchain, i.e., private Blockchain, for storing the data in the medically documented ledger, which can be shared among hospitals as well as Health organizations. The second approach is incorporated with a deep learning algorithm. With the help of algorithms, we can analyse the ledger, after which an alert i.e. consultation, health diet, medication, etc., will be sent to the patient’s registered mobile device. The proposed work uses nine features from the dataset; the features are identification number, age, person gender, disease, weight, consultation date, medication, diagnosis, and diet specification. The study is conducted with several features to give accurate results. The integrated model used in this suggested piece of work automates the patient's alert system for a variety of activities. In terms of precision, recall, and F1 score, testing data demonstrate that the LSTM performs better than the other models. By working together with the calendar software on Android mobile devices, alert systems can be improved in the future.
Probiotics and Health: A Review
Authors: Tomar Priti , Sharma Shikha , Dangi Neha 
Published: May 2023

Abstract:
Humans serve as hosts for various species of microorganisms that contribute to the maintenance
of human health. The beneficial bacteria residing in our bodies are referred to as probiotics.
Besides improving the immune system, probiotics are also capable of warding off various diseases. In
recent decades, probiotic microorganisms have emerged as a significant factor in human well-being.
Popularly referred to as "health-friendly microorganisms," they influence health in myriad ways by
boosting the immune system, combating intestinal irritation, improving the balance of the gut microbiome,
lowering blood pressure, relieving postmenopausal symptoms, and reducing traveler’s diarrhea.
The ability of probiotics to compete for the adhesion sites of pathogenic microbes makes them
an effective treatment against various intestinal pathogens. Recent studies also advocate their use in
the treatment of skin and oral diseases. In addition, the modulation of gut flora by probiotics is being
discussed as a possible new solution for treating tension and depression. Ultimately, a cost-effective
approach is imperative to improve and maintain fitness in the present competitive environment. This
review aims to evaluate the potential benefits of probiotic microorganisms in various disorders, such
as gastrointestinal disorders, UTIs, acne, anticancer properties, gut-brain connections, and their possible
mode of action.
Improving reading comprehension through the development of critical thinking of students at madrasah aliyah
Authors: Mustopa Arif Zaenal , Sugirin Sugirin 
Published: May 2023

This research aims to develop the reading comprehension skills in English written texts of Grade XI students of Madrasah Aliyah Al-Ikhlash Cicalengka, Bandung through the development of critical thinking in teaching process. This research was collaborative classroom action research. The subjects were the 11th grade students of Madrasah Aliyah Al-Ikhlash Cicalengka, Bandung. The data were collected through pretest and posttest, observation, field notes, and interviews. The students were introduced with the concept of critical thinking starting with the concept of position, agreement, disagreement, and argument as well as the categorization of the opinion and fact in the text. Finally the students were asked to do some tasks and give their opinion related to the position of the writer and their background knowledge. The result showed that there was an improvement in teaching processes. In the first cycle, the students’ involvement in classroom activity was improved. There were about 70% of the students who actively involved in the process and it increased in the second cycle. In expressing opinion, the students could actively express their opinion related to the text being discussed both in written and orally. The improvement also occurred in students’ reading comprehension skills score. The result of paired t-test showed that there was significant different in comparison of pretest and both posttests 1 and 2. The result showed that the significant value of 0.000 was smaller than the significant level of 0.05 or 5%. This means that the improvement was significant. The result proved that improving reading comprehension skills could be achieved by developing critical thinking in teaching reading process.