bluuebunny/crossref_metadata_2025_split huggingface dataset:
The co-crystal structure of etoricoxib–phthalic acid (1/1), C18H15ClN2O2S·C8H6O4
Authors: Ma Yu-Heng , Zhu Miao-Miao , Zhang Chun-Ni , Tang Xiao-Sa , Zhang Wei-Guo , Ma Wen-Jing 
Published: April 2023

Abstract
C18H15ClN2O2S·C8H6O4, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 8.4340(17) Å, b = 12.172(2) Å, c = 12.816(3) Å, α =

89.98

(
3
)

°

$89.98(3){}^{\circ}$

, β =

77.41

(
3
)

°

$77.41(3){}^{\circ}$

, γ =

72.52

(
3
)

°

$72.52(3){}^{\circ}$

, V = 1221.7(5) Å3, Z = 2, R

gt
(F) = 0.0482, wR

ref
(F
2) = 0.1344, T = 293 K.
Verifica di un pregiudizio scettico
Authors: Conte Gian Biagio 
Published: April 2023

AbstractThe author returns to a much debated topic, the so-called “Episode of Helen”, which has come to us only through indirect transmission, and endeavors to dismantle the prejudice against Virgilian authorship. G. P. Goold’s pugnacious intervention, dating back to more than half a century ago, contributed decisively – in fact, more than it should have – to the thesis that the text is spurious. A critical analysis of the text will demonstrate this claim to be groundless while offering arguments that support the authenticity of the episode.
Glucagon-Like Peptide-1 Receptors in the Gustatory Cortex Influence Food Intake
Authors: Dossat Amanda M. , Kokoska Milayna M. , Whitaker-Fornek Jessica R. , Sniffen Sarah E. , Kulkarni Aishwarya S. , Levitt Erica S. , Wesson Daniel W. 
Published: May 2023

The gustatory cortex (GC) region of the insular cortex processes taste information in manners important for taste-guided behaviors, including food intake itself. In addition to oral gustatory stimuli, GC activity is also influenced by physiological states including hunger. The specific cell types and molecular mechanisms that provide the GC with such abilities are unclear. Glucagon-like peptide 1 (GLP-1) is produced by neurons in the brain, where it can act on GLP-1 receptor-expressing (GLP-1R+) neurons found in several brain regions. In these brain regions, GLP-1R agonism suppresses homeostatic food intake and dampens the hedonic value of food. Here, we report in mice of both sexes that cells within the GC expressGlp1rmRNA and further, byex vivobrain slice recordings, that GC GLP-1R+ neurons are depolarized by the selective GLP-1R agonist, exendin-4. Next we found that chemogenetic stimulation of GLP-1R+ neurons, and also pharmacological stimulation of GC-GLP-1Rs themselves, both reduced homeostatic food intake. When mice were chronically maintained on diets with specific fat contents and then later offered foods with new fat contents, we also found that GLP-1R agonism reduced food intake toward foods with differing fat contents, indicating that GC GLP-1R influences may depend on palatability of the food. Together, these results provide evidence for a specific cell population in the GC that may hold roles in both homeostatic and hedonic food intake.SIGNIFICANCE STATEMENTThe present study demonstrates that a population of neurons in the GC region of the insular cortex expresses receptors for GLP-1Rs, these neurons are depolarized by agonism of GLP-1Rs, and GC GLP-1Rs can influence food intake on their activation, including in manners depending on food palatability. This work is significant by adding to our understanding of the brain systems that mediate ingestive behavior, which holds implications for metabolic diseases.
FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels
Authors: Elcocks Hannah , Brazel Ailbhe J , McCarron Katy R , Kaulich Manuel , Husnjak Koraljka , Mortiboys Heather , Clague Michael J , Urbé Sylvie 
Published: April 2023

AbstractSelective autophagy of mitochondria, mitophagy, is linked to mitochondrial quality control and as such is critical to a healthy organism. We have used a CRISPR/Cas9 approach to screen human E3 ubiquitin ligases for influence on mitophagy under both basal cell culture conditions and upon acute mitochondrial depolarization. We identify two cullin‐RING ligase substrate receptors, VHL and FBXL4, as the most profound negative regulators of basal mitophagy. We show that these converge, albeit via different mechanisms, on control of the mitophagy adaptors BNIP3 and BNIP3L/NIX. FBXL4 restricts NIX and BNIP3 levels via direct interaction and protein destabilization, while VHL acts through suppression of HIF1α‐mediated transcription of BNIP3 and NIX. Depletion of NIX but not BNIP3 is sufficient to restore mitophagy levels. Our study contributes to an understanding of the aetiology of early‐onset mitochondrial encephalomyopathy that is supported by analysis of a disease‐associated mutation. We further show that the compound MLN4924, which globally interferes with cullin‐RING ligase activity, is a strong inducer of mitophagy, thus providing a research tool in this context and a candidate therapeutic agent for conditions linked to mitochondrial dysfunction.
Communication Experiences of Caregivers Using a Language Other Than English on Inpatient Services
Authors: Maletsky Kristin D. , Worsley Diana , Tran Lopez Kim , Del Valle Mojica Coralee , Ortiz Priscilla , Bonafide Christopher P. , Tenney-Soeiro Rebecca 
Published: May 2023

OBJECTIVES
Individuals who prefer to communicate about health care in a language other than English (LOE) experience poorer quality medical care and challenges when communicating with health care providers. The objective of this study was to elucidate how caregivers who prefer an LOE perceive communication with their physicians on an inpatient general pediatrics service.

METHODS
Caregivers of patients admitted to the general pediatrics service at our urban freestanding children’s hospital whose preferred language for medical care was Spanish, Arabic, Brazilian Portuguese, or Mandarin were eligible for this qualitative study. Semistructured interviews using video interpreter services were conducted to explore the participants’ experiences communicating with their physicians. Interview transcripts were analyzed using conventional content analysis.

RESULTS
We interviewed 15 participants representing 7 countries of origin and 4 non-English languages: Spanish, Arabic, Brazilian Portuguese, and Mandarin. Three main domains emerged, including: (1) use of interpreter services, (2) overall communication experience with physician providers, and (3) suggestions for improvement in physician communication. Salient themes included early identification of the need for an interpreter is essential and physicians’ use of body language in combination with an interpreter enhances successful communication.

CONCLUSIONS
This project fills a gap in existing literature by describing the perspectives of caregivers who prefer an LOE, including those speaking languages other than Spanish, as they communicate with inpatient pediatricians. In addition to ensuring appropriate use of interpreter services, physicians can focus on using plain language and gestures during encounters, helping to facilitate communication and provide culturally competent care for this population.
Long-term Adverse Outcomes Associated With Teen Dating Violence: A Systematic Review
Authors: Piolanti Antonio , Waller Franziska , Schmid Iason E. , Foran Heather M. 
Published: May 2023

CONTEXT
Evidence suggests that teen dating violence (TDV) is associated with long-term adverse outcomes, but these associations have not been systematically assessed.

OBJECTIVES
To conduct a systematic review of the longitudinal associations between TDV and negative outcomes, including mental and physical health, reoccurrence of violence in intimate relationships, and high-risk behaviors (substance use and sexual behaviors).

DATA SOURCES
Peer-reviewed articles published in English were searched in PsycINFO/Eric/PsycArticles, PubMed, and Web of Science database from inception to November 2022.

STUDY SELECTION
Prospective studies that assessed TDV during adolescence, had a follow-up of at least ≥1 year, and evaluated the associations of TDV with health, violence in romantic intimate relationships, or risk behaviors were included.

DATA EXTRACTION
Study characteristics, baseline data, and follow-up outcomes were extracted from included studies.

RESULTS
Thirty-eight studies involving 23 unique samples were analyzed. Findings showed that TDV in adolescence was associated with future teen dating and intimate partner violence in adulthood. Studies also indicated that TDV was longitudinally associated with increasing high-risk behaviors (ie, marijuana and alcohol use) and poor mental health outcomes (particularly for victimization). There was unclear evidence on the longitudinal link between TDV and suicidal attempts. Significant associations between TDV and negative outcomes were reported more frequently among females compared with males.

LIMITATIONS
Length of follow-up varied across studies.

CONCLUSIONS
Dating violence in adolescence may represent a risk factor for a wide range of long-term outcomes. Female adolescents reporting TDV may be at higher risk of adverse outcomes compared with males.
Family Violence Reduction Within a Parenting Intervention in Rwanda: A Mixed-Methods Study
Authors: Jensen Sarah K.G. , Murray Shauna M. , Placencio-Castro Matias , Kajani Ursula , Amponsah Deborah , Sezibera Vincent , Betancourt Theresa S. 
Published: May 2023

BACKGROUND AND OBJECTIVES
A mixed-methods study of mechanisms of change through which a home-visiting-based early childhood development intervention, Sugira Muryango (“strong family”), reduced violent discipline and intimate partner violence in Rwanda.

METHODS
The cluster-randomized trial of Sugira Muryango enrolled socioeconomically vulnerable families with children aged 6 to 36 months in rural Rwanda. We interviewed 18 female caregivers early in the intervention, and 21 female caregivers and 11 male intimate partners were interviewed after the intervention. Coded interviews identify risk factors for violence and mechanisms of intervention-related change in violence. Quantitative analyses included 931 caregivers (52.6% female) who lived with an intimate partner to examine risk factors for violence, intervention effects, and mechanisms of violence reduction.

RESULTS
The qualitative data identified daily hardships and alcohol problems as risk factors for violent discipline and intimate partner violence. Through Sugira Muryango, caregivers learned that strong relationships between partners and engagement of male caregivers in child care has positive impacts on children's development. Techniques taught by community lay workers improved communication, promoted positive parent–child interactions, and reduced intimate partner violence and violent discipline. Quantitative analyses also found that daily hardships predict violent discipline and intimate partner violence. Sugira Muryango reduced violent discipline, increased father engagement, and increased female caregiving warmth. Moreover, pre- to postintervention change in caregiving warmth was associated with reduced use of violent discipline among female caregivers and marginally associated with reduced female victimization.

CONCLUSIONS
Violence reduction can be integrated into early child development programs to reduce violent discipline and intimate partner violence.
The Process of Scaling Early Childhood Violence Prevention Programs in Jamaica
Authors: Baker-Henningham Helen , Bowers Marsha , Francis Taja 
Published: May 2023

BACKGROUNDViolence is a global public health problem, and early childhood interventions are a core component of violence prevention programming. Interventions to support parents and teachers of young children can prevent violence against children by caregivers and prevent the early development of antisocial behavior. However, there is limited guidance on how to scale up these programs in low- and middle-income countries.METHODSIn this article, we describe how we applied implementation science principles in the design, implementation, evaluation, and initial scaling of 2 complementary early childhood, violence prevention, caregiver training programs in Jamaica: the Irie Classroom Toolbox (a teacher-training program) and the Irie Homes Toolbox (a parenting program).RESULTSWe identified 7 implementation science principles most relevant to our work in scaling the Irie Toolbox programs and describe how these principles were operationalized in the Jamaican context. The principles are: (1) design programs for scale from the outset; (2) use learning cycles for quality improvement; (3) plan strategically for government agency adoption; (4) provide high-quality initial and ongoing training and regular supervision; (5) monitor implementation quality; (6) use flexible delivery modes; and (7) plan for program sustainment.CONCLUSIONSThrough applying these principles to scale the Irie Toolbox programs, we aim to promote a consistent approach to reducing violence against children, reducing child behavior problems, and increasing caregiver and child competencies across both home and school contexts at the population level. The principles and processes described in this article are relevant to other behavior change interventions in early childhood development, education, and public health.
The Maternity Leave and Cash Benefit Payment System for Readymade Garment (RMG) Sector of Bangladesh
Authors: Akter Salma 
Published: April 2023

Maternity leave means the period of paid absence from work. This type of leave is allowed to a mother before and after the birth of a child. Naturally, the term maternity benefit is applied in case of working women. Mostly, it is related to readymade garment (RDM). It indicates the payment made to a woman for giving birth of a child. The duration of maternity leave for female worker in RMG sector of Bangladesh is 4 months (16 weeks) according to Labor Act 2006. The purpose of this study is to show the application of RMG sector’s maternity leave and to assess the level of cash benefit payment for maternity leave. The main purpose of this study is to show the discrimination between two kinds of factories (foreign owned and local owned) about the proper application of rules and Act. The information collected from those who are experienced to take maternity leave and recently take the leave and also who are preparing for the leave.
Frequency distribution has been used on the data extracted from female worker who have experience maternity leave and cash benefit payment. The result of this study is that there are two kinds of RMG sectors situations: one is called foreigner owned factory and another one is Bangali factory (local owner).Evidently, 60% get the cash payment with two terms before & after child born and 100% get the maternity leave. So, this paper will discuss about the differences of facilities, job security, cash payment, others opportunities for female in RMG sector.
Nuevas estrategias de la Unión Europea para abordar el doble reto de la crisis climática y la dependencia energética
Authors: García Lupiola Asier 
Published: April 2023

Desde la entrada en vigor del Tratado de Lisboa, la Unión Europea desarrolla una política integrada en materia de medio ambiente y energía que le posibilita adoptar medidas para hacer frente de manera conjunta a los retos que plantean el cambio climático y la seguridad de abastecimiento energético. Actualmente, la Unión Europea se encuentra en el proceso que le lleve a cumplir sus compromisos en materia de clima y energía previstos para 2030. Dichos objetivos se fijaron inicialmente en 2014 pero desde entonces se han visto ampliados en varias ocasiones. Las razones han sido diferentes: en primer lugar, el irregular grado de cumplimiento de los objetivos para 2020; posteriormente, el objetivo de neutralidad climática propuesto en 2018 y el Pacto Verde Europeo adoptado para su consecución y cuyo desarrollo se inició en 2020; finalmente, el complicado contexto geopolítico de 2022. El presente texto analiza y trata de explicar dicha evolución hasta las propuestas más recientes.
Recibido: 12 diciembre 2022Aceptado: 17 enero 2023
Desfigurando la memoria: (des)atando los nudos de la memoria peruana
Authors: Milton Cynthia E. 
Published: April 2023

Este artículo analiza las corrientes opositoras a la memoria colectiva de la sangrienta guerra interna del Perú (1980-2000) a través de un análisis de los actos de vandalismo perpetrados contra uno de los pocos sitios dedicados a la memoria en este país, El ojo que llora, ubicado en Lima. ‘Vandalismo’, en este artículo, es entendido como una forma de escritura (aunque violenta) de una visión distinta del pasado. Originalmente concebido como un espacio para recordar y rendir homenaje a las víctimas del conflicto armado, el sitio se ha convertido en un lugar para la confrontación de formas distintas de asumir el pasado. Como sitio de recuerdo y reivindicación de derechos humanos, y sobre todo como blanco de intentos de desfiguración permanente, El ojo que llora se ha convertido en un escenario en el que la presencia perdurable del pasado —con sus conflictivas tensiones— se hace visible para el público nacional e internacional. Así, se niega el cierre mismo que las narrativas del gobierno quisieran imponer y, por lo tanto, se mantiene el compromiso público con el pasado. Los conflictos en curso sobre el pasado se hacen visibles en este punto en las luchas por establecer una memoria general y, en este proceso, el significado mismo de ‘víctima’ se ve implicado.
Les Outils d'Analyse du Marketing au Profit des Partis Politiques Marocains
Authors: Hniche Omar , Amara Achraf 
Published: May 2023

Le Marketing Politique est un concept qui existe depuis la nuit des temps, mais qui n'a pas été défini comme tel, c'était une pratique exercée par les hommes politiques et les notables pour se construire une image. Aujourd'hui, ces pratiques sont résumées sous le nom de 'Marketing politique' et font l'objet de diverses études et analyses. Afin de profiter des avancées en Marketing, les partis politiques et les hommes politiques peuvent utiliser des outils d'analyse Marketing tels que la matrice BCG, l'analyse SWOT et SCP, c'est ce que nous avons fait lors de cette étude pour analyser les partis politiques pionniers au Maroc, à savoir : PJD, PAM, RNI, PI. De cette étude il ressort que ces partis utilisent les mêmes méthodes de marketing politique mais que la différence majeure reste le positionnement et l'image qu'ils tentent de construire dans l'esprit des citoyens.

Political Marketing is a concept that has been existing since the dawn of time, but which was not defined as such, it was a practice adopted by politicians and notables to create an image. Today, this practice is named (or identified as) 'Political Marketing' and is the subject of various studies and analysis. In order to take advantage of advances in Marketing, political parties and politicians can use Marketing analysis tools such as the BCG matrix, SWOT analysis and SCP, this is what we did in this study to analyze the pioneer political parties in Morocco, namely: PJD, PAM, RNI, PI. From this study it emerged that these parties use the same methods of political marketing but that the major difference remains the positioning and the image that they try to build in the mind of citizens.
The Effectiveness of Producing a Blended Learning Environment Based on the Programming of an Educational Robot to Develop Problem-solving Skills in Science for Intermediate School Students in the Kingdom of Saudi Arabia
Authors: Elmorsy Agwa Mohamed Gomaa , El-Desouki Mohamed Ibrahim , Elnagar Mohamed Elsayed 
Published: May 2023

This study aimed to examine the effect of producing a Blended learning environment based on the programming of an educational robot to develop problem-solving skills in Science for intermediate school students in the Kingdom of Saudi Arabia. The sample of the study consists of (60) intermediate school students. A total of Four research questions and hypotheses were used in the study. A pre-post-test design was used to achieve the study's objectives in which special treatment was given to the experimental group, whereas no treatment was given to the control group. SPSS was used as a statistical tool to examine the present research results. The study's results proved the effectiveness of a Blended learning environment based on the programming of an educational robot in developing problem-solving skills in Science for intermediate school students in the Kingdom of Saudi Arabia, as the experimental group showed a better performance in the post-test than the control group. Moreover, the correlation test results indicated a significant positive relationship between the Blended learning environment based on the programming of educational robot performance and students' developing problem-solving skills in Science.
Diagnostic et Traitement des Complications des Suites de Couches au Centre Hospitalier Universitaire de Kara
Authors: Ténété Assiaham Walawita , Logbo-Akey Kossi Edem , Yendoubé Kambote , Aboubakari Abdoul-Samadou , Ajavon Dédé Régine Diane 
Published: May 2023

Introduction : Le but de cette étude est de déterminer les principales complications des suites de couches à la maternité du CHU-Kara. Patientes et Méthodes : Il s’est agi d’une étude rétrospective et descriptive menée du 1er janvier 2017 au 31 décembre 2020 portant sur les complications des suites de couches. Résultats : Parmi les accouchées nous avons enregistré 300 cas de complications du post partum soit une fréquence de 3,13%. La majorité des patientes était référée (59,33% n=178) avec une tranche d’âge comprise entre 18 et 30 ans (49% n=147). Les complications hémorragiques représentaient 59,31%(n=178), l’anémie du post partum 17%(n=51), l’endométrite 9,33% (n=28) et l’éclampsie du post partum 6,30 % (n=20). Toutes ces complications ont nécessité une prise en charge médicale et chirurgical. L’hystérectomie et la triple ligature vasculaire ont été effectuées respectivement dans 1,69% (n=5) et 3%(n=9) des cas. Nous avons enregistré 17 décès maternels soit 6%. Conclusion : Il ressort de cette étude que les complications hémorragiques étaient les plus fréquentes en suites de couche au CHU Kara. La meilleure prise en charge de ces complications du post partum passerait par une meilleure réorganisation du système de prise en charge et un renforcement du plateau technique de toutes les structures sanitaires.

Introduction: The aim of this study is to determine the main complications of the postpartum period at the maternity hospital of CHU-Kara. Patients and Methods: This was a retrospective and descriptive study conducted from January 1, 2017, to December 31, 2020, on the complications of postpartum. Results: Among the women who gave birth, we recorded 300 cases of postpartum complications, i.e. a frequency of 3.13%. The majority of patients were referred (59.33% n=178) with an age range between 18 and 30 years (49% n=147). Bleeding complications represented 59.31% (n=178), postpartum anemia 17% (n=51), endometritis 9.33% (n=28), and postpartum eclampsia 6.30% (n=20). All these complications required medical and surgical management. Hysterectomy and triple vascular ligation were performed in 1.69% (n=5) and 3% (n=9) of cases respectively. We recorded 17 maternal deaths (6%). Conclusion: This study shows that hemorrhagic complications were the most frequent complications of childbirth at Kara University Hospital. The best management of these post-partum complications would require a better reorganization of the management system and a strengthening of the technical platform of all health facilities.