bluuebunny/crossref_metadata_2025_split huggingface dataset:
The NK cell checkpoint NKG2A maintains expansion capacity of human NK cells
Authors: Kaulfuss Meike , Mietz Juliane , Fabri Astrid , Berg Johannes vom , Münz Christian , Chijioke Obinna 
Published: May 2023

Abstract
Human natural killer (NK) cells are cytotoxic effector cells that are increasingly harnessed in cancer immunotherapy. NKG2A/CD94 is an inhibitory receptor on NK cells that has established regulatory functions in the direct interaction with target cells when engaged with its ligand, the non-classical HLA class I molecule HLA-E. Here, we confirmed NKG2A as a checkpoint molecule in primary human NK cells and identified a novel role for NKG2A in maintaining NK cell expansion capacity by dampening both proliferative activity and excessive activation-induced cell death. Maintenance of NK cell expansion capacity might contribute to the preferential accumulation of human NKG2A+ NK cells after hematopoietic cell transplantation and enrichment of functionally impaired NK cells in human cancers. Functional silencing of NKG2A for cancer immunotherapy is highly attractive but will need to consider that this might also lead to a reduced survival by driving activation-induced cell death in targeted NK cells.
Prevalence and Factors Associated with Female Sterilization in Rwanda: Evidence from the 2019/2020 Demographic and Health Survey Data
Authors: Ndayishimye Samuel , NAHAYO Bonfils , OLORUNFEMI Gbenga 
Published: May 2023

Abstract
Background
Female sterilization is a safe and effective surgical procedure of achieving contraception. Female sterilization is commoner in high income countries as compared to low- and middle-income countries such as Rwanda because of demand to limit family size. However, current evidence of the uptake of female sterilization in Rwanda is not known. We therefore evaluated the prevalence and factors associated with female sterilization among women of reproductive age in Rwanda.
Methodology
This was a secondary data analysis of 14,634 women of reproductive age (15-49) in Rwanda. The data utilized was from the Rwanda Demographic Health and Survey (RDHS) from 2016 to 2020. The predictors of female sterilization were determined using multivariable binary logistic regression.
Results
Findings of this study revealed that the prevalence of female sterilization was 1.1% among women of reproductive age in Rwanda. Older than 35 years old women had 8 times more chance to get sterilized than younger women (aOR: 7.87, 95% CI: 4.77-12.99). Women living with their partners had more odds compared to never married women(aOR: 19.225, 95% CI: 4.57-80.82), women from minority religion are more likely to get sterilized compared to those from catholic religion(aOR: 2.12, 95% CI: 1.03- 4.37), women from rich household had more chance to get sterilized compared to their counterparts from poor household (aOR: 3.13, 95% CI: 1.94-5.03), women from western region were more likely to uptake sterilization compared to women from Kigali (aOR: 2.025, 95% CI: 1.17-3.49) and women who had more than 5 children had more odds compared to women who had equal or less than 5 children (aOR: 1.49, 95% CI: 1.06-2.10).
Conclusion
The overall prevalence of sterilization among Rwandan women of reproductive age was 1.1%, which was very low as compared to India 29%, China 14.1% and USA 13.7 %. The age, marital status, religion, household wealth quintile, region and children ever born was associated with the uptake of female sterilization among Rwandan women. Government and stakeholders should enhance mobilization about the permanent methods.
Design of English video course platform based on machine learning and Sobel algorithm
Authors: Zhao Ling , Chen Lijiao , Zhang Junchi , Liu Ying 
Published: May 2023

Abstract
English video teaching is an indispensable part of English teaching, but there are certain difficulties in the design of English video courses, which need to be guided by artificial intelligence methods. Based on machine learning algorithm and Sobel algorithm, this paper builds an English video classroom design platform, uses image technology to process video, and proposes an improved algorithm based on Sobel operator. Moreover, this paper uses Sobel horizontal and vertical detection operators to define the edge strength of the block to be repaired, and introduces a weight factor to enable the improved algorithm to repair images with different texture levels. In addition, this article improves the original SSD by introducing STD based on the image standard deviation, and uses the degree of gray value dispersion between image blocks as a criterion for comparing whether two image blocks are similar, which effectively improves the accuracy of the search strategy. The experimental results show that the algorithm constructed in this paper can play a certain effect in teaching.
Shift-Left Testing Paradigm Process Implementation for Quality of Software Based on Fuzzy
Authors: Vaddadi Srinivas Aditya , Thatikonda ramya , Padthe Adithya , Arnepalli Pandu Ranga Rao 
Published: May 2023

Abstract
Traditionally, testing is done first at end of the design phase, however this is no longer the case. Testing, finding, and categorising bugs, as well as releasing the development changes into the product, carries a price tag. If the test/verification team discovers a high-severity issue at the end of the lifecycle, the costs may climb. Even if all of the issues are resolved, the release could be delayed. Shift-Left testing is done in isolation by the test/verification team and does not increase testing time, but it has demonstrated to be in sync with product development in some cases. In the context of a process, shifting-left refers to taking action early on. Shift-left testing refers to the practise of testing software earlier in the development cycle than is customary, or to the left in the delivery pipeline, as opposed to the traditional practise of testing software later in the development cycle. Shifting to a "shift left" strategy assumes that the software development team may find bugs faster if they test their code as it is being written, rather than waiting until the end of the project based on fuzzy. Before the code is available for testing, shift left testing encourages developers to write test cases. An agile software development strategy known as "shift left" stresses putting test cases in place early in the life cycle of a project rather than at the conclusion. It also means that automated tests will cover a larger portion of a project's planned functionality rather to just a small portion. The shift left testing adoption benefits the organization to reduce the development cost and time as the testing is done along with development to avoid delay in the process. This paper analyse the benefits of organizations who adopted shift left testing in the software development process.
Obesity and temporomandibular joint disorders: a systematic review and meta-analysis
Authors: Wang Xia , Yang Yan , Lin Linni , Yao Qianqian , Zhang Jingjing 
Published: May 2023

Abstract
Background Temporomandibular joint disorders (TMD) is the most common non-dental pain complaint in the maxillofacial region, which presents a variety of symptoms and signs, including temporomandibular joints (TMJ) and masticatory muscle pain, joint noise, tinnitus, headaches, irregular or restricted mandibular function, masticatory difficulty, and restricted mouth opening. When comes to the relationship between obesity and TMD, it has remained controversial and inconsistent, therefore, we first conducted this meta-analysis to estimate the unclear relationship between obesity and TMD.Methods Searches were conducted in PubMed, Web of Science, Embase, and Cochrane Library. Subjects were divided into five groups according to BMI level in this study, including the normal weight group: 18.5 ≤ BMI < 23, obesity Ⅰ group: 25 ≤ BMI < 30, obesity Ⅱ group: BMI ≥ 30, non-obesity group: BMI < 25, and obesity group: BMI ≥ 25. Statistics analyses were conducted using Stata (15.0). The number of PROSPERO was CRD42022368315.Results Eight studies were included in this study, and six articles with a total of 74056 participants were synthesized for meta-analysis. Compared to normal weight individuals, the obesity Ⅰ decreased the risk of TMD (OR = 0.80, 95%CI = 0.69–0.94), and it was significantly decreased by obesity Ⅱ (OR = 0.74, 95%CI = 0.56–0.97). Moreover, it was lower in obesity compared with non-obese subjects (OR = 0.83, 95% CI = 0.73–0.94). Furthermore, in obese individuals, it was much lower in obesity Ⅱ than obesity Ⅰ (OR = 0.82, 95% CI = 0.71–0.94).Conclusions Obesity is not a risk factor for TMD, and maybe a protective factor for TMD, of which patients with larger BMI are less likely to suffer from TMD pain. Therefore, the value of BMI should be taken into consideration in the assessment of TMD.
Effect of Iranian propolis on potassium dichromate reabsorption in Redfish (Carassius auratus)
Authors: Heidarieh Marzieh , Naeimi Saeideh , Nikrou Bagher , Multisanti Cristiana Roberta , Faggio Caterina 
Published: May 2023

Abstract
Chromium is an abundant metal in the earth's crust and plays an important role in water pollution. There are two main forms of chromium in the environment: trivalent chromium and hexavalent chromium, as the most toxic form. The present study investigated the effects of propolis on the amount of chromium reabsorption in the Redfish's liver, kidney, gill, and muscle. Redfish were fed on four diets treated with irradiated/non-irradiated alcohol extract and irradiated/non-irradiated crude crushed propolis as an antioxidant natural bee product, for 70 days. Treatments and the positive control groups were exposed to 9 mg/L of chromium for 6 weeks. According to the data available in this study, the amount of chromium reabsorption in the positive control groups is in the order of gill > liver > kidney > muscle. The irradiated propolis diet treatment groups showed a significant difference compared to the positive control group. Treatment groups 3 and 4 showed significant differences compared to treatment groups 1 and 2 in all organs, except the liver. Treatment groups 3 and 4 showed a lower amount of chromium reabsorption in the gills, liver, kidneys, and muscles compared to the positive control group, demonstrating a significant difference. The results obtained showed that propolis could be effective as a chemoprotective compound in managing the reabsorption of dichromate. Therefore, it can be concluded that irradiated alcohol extract of propolis is recommended as a suitable and convenient food additive to increase its antioxidant properties in the fish industry.
Inherit or innovation? Research on the brand revitalization of China Time-honored Brands
Authors: Xiang Yongsheng 
Published: May 2023

Abstract
The sustainable development of time-honored brands in the new era is faced with the dilemma of inheritance or innovation. By selecting Wufangzhai company of Jiaxing city in China as the research object and conducting case study, it is found that the enterprise not only inherits the quality, ingenuity and culture of the time-honored brand, but also innovates in R&D, marketing, organizational structure and business strategy. The process of inheritance and innovation of time-honored brands is a blend of “DAO” and “SHU” in Chinese. “DAO” (principle) refers to the brand's concept rules and deep cores; “SHU” (skill) refers to the brand's methods and forms of display. Analysis from the perspective of levels constituted the brand, what is inherited are the real core internal elements and powers of the brand, which help to maintain the internal authenticity, consistency and continuity of the time-honored brand; what is innovated are the external levels of the brand, which helps to promote the external elements of the time-honored brand in fashion, novelty and flexibility. The ambidexterity equilibrium of brand management and revitalization in the “DAO” of inheritance and the “SHU” of innovation, reflects the dialectical logic of change and changeless: centering on improving the value of brand equity, adhering to the core of the brand on the one hand, breaking through the external form on the other hand, its essence is unified around better meet customer’s needs.
Effect of Chromated Copper Arsenate impregnation treatment on flexural and shear properties of Glue Laminated Eucalyptus grandis
Authors: Zziwa Ahamada , Nabacwa Allen Kyolaba , Kizito Simon , Syofuna Agatha 
Published: May 2023

Abstract
This study examined the effect of Chromated Copper Arsenate (CCA) preservative treatment on selected mechanical properties of glue laminated Eucalyptus grandis wood. Test specimens were prepared and tested for Modulus of Elasticity [MOE], Modulus of Rupture [MOR] and shear strength using a Universal Testing Machine in accordance with ASTM D198 and BS373. The soaking delamination test was used to test for delamination percentage. The data was analyzed using the Levene’s test for the flexural properties (MOE and MOR) and one-way ANOVA test for the shear properties at 95% significance level. The results showed that MOE and MOR decreased in the treated glulam samples by 19.1% and 13.3% respectively. The shear strength properties also decreased in the treated samples by 3.3%. However, no delamination was found in all glulams. The treated wood glulams had lower MOE, MOR and shear strength properties than that of the untreated glulams but no significant differences in strength properties were detected. In conclusion, treatment of the eucalyptus glulam with CCA does not significantly weaken its flexural and shear properties. It is recommended that glulams extracted from CCA treated Eucalyptus grandis should not be used for high structural purposes but could be used in light construction works.
Unusual Case of Management of Osteomyelitis after Orthognathic Surgery: Mandibular Reconstruction with TMJ Prosthesis
Authors: Leal João Victor Borges Leal , Santo Luciano Mauro Del Santo Del , Nasim Omar Nasim Mohamed Nasim Khan Maboob , Ramos Thiago Ramos Magalhaes , Cavalcante Mateus Barros Cavalcante , Pessoa José Valdir Pessoa Neto 
Published: May 2023

Abstract
This case report presents a rare case of osteomyelitis following bimaxillary orthognathic and geioplasty surgeries. The patient, a 41-year-old female, presented with facial pain, difficulty in opening her mouth, and mandibular deviation four months after the initial orthognathic surgery. During the four months, the patient had experienced two post-operative complications that required surgical intervention. Examination revealed mobility between osteotomy segments of the right mandibular body, and Computer Tomographic scan analysis revealed osteomyelitis, and non-union of the right osteotomy side of the mandible from the previous surgery. Due to the advanced state of the disease and significant bone resorption, treatment was planned in two stages, involving bone debridement and then reconstruction with a custom made extended temporomandibular joint prosthesis. The patient had no postoperative complications and achieved satisfactory functional and aesthetic outcomes. This case emphasizes the importance of careful monitoring and prompt management of postoperative complications following orthognathic surgery to prevent rare but serious complications such as osteomyelitis.
Potential Applications of Silicate Solubilizing Bacteria and Potassium Silicate on Sugarcane Crop under Drought Condition
Authors: Anitha R. , Vanitha K. , Tamilselvi C. , Jeyakumar P. , Vijayalakshmi D. , Yuvaraj M. , Nageswari R. , Dhanushkodi V. , cyriac Jaiby 
Published: May 2023

Abstract
The decline of soil nutrient status and productivity of crops, and restoration of soil health is a key global problem. Crop yields are reduced by soil degradation, which endangers the world's food supply. Crop yields and soil health are further decreased by improper fertilizers in conjunction with intense cropping. A wide variety of plants, particularly monocotyledonous crops that can collect significant levels of silicon in their organs, have shown the benefits of silicon in terms of growth, biomass, and yield. According to the results, silica solubilizer was applied to the soil at a rate of 12.5 kg, 50 kg FYM/ha, and setts were treated with 0.5% K2 SiO3 and 2.5% urea and potash foliar spray every 15 days between 60 and 150 days after planting (DAP) showed, leaf area, maximum tiller population, specific leaf area, leaf area index, macro, and micronutrients, specific leaf weight, quality parameters and commercial cane sugar percent both the ratoon crop and the plant are in drought condition.
Differences of regional homogeneity and cognitive function between psychotic depression and drug-naïve schizophrenia
Authors: Chen Wensheng , Li Xiaoling , wu Weibin , Li Wenxuan , Huang Wei , Li Zhijian , Xu Caixia , Xie Guojun , Li Xuesong , Zhang Chunguo , Liang Jiaquan 
Published: May 2023

Abstract
Background: Psychotic depression (PD) and schizophrenia (SCZ) are disorders with shared symptoms but unique causes, development, and treatments. Identifying them based on symptoms is difficult, requiring deeper comprehension of cognitive and neural mechanisms for accurate diagnosis and treatment.
Aim: This study aims to compare cognitive impairments and brain functional activities in PD and SCZ, in order to identify unique features of each disorder.
Methods: We studied 42 PD and 30 SCZ patients using RBANS and rs-fMRI. We computed ReHo values from the rs-fMRI data and compared RBANS scores between groups. We also investigated the correlation between cognition and brain function using Pearson analysis.
Results: (1) SC group had lower RBANS scores than PD group in all test sections; (2) Left precuneus had significant ReHo difference between PD and SC groups, with SCZ group showing significantly increased ReHo (p < 0.05); (3) Negative correlation found between visuospatial construction score, delayed memory score and ReHo value of left precuneus by Pearson correlation analysis.
conclusion: Cognitive impairment is more severe in SCZ than PD. Elevated left precuneus activity distinguishes PD from SCZ and relates to cognitive deficits in both, offering neuroimaging evidence for differential diagnosis and insight into cognitive impairment pathology.
Applying the PRECIS-2 tool to pragmatic acupuncture trials: are they pragmatic? A systematic review
Authors: Lim Jinwoong , Lee Hyeonhoon , Kim Yong-Suk 
Published: May 2023

Abstract
Background
Pragmatic acupuncture trials (PATs) are a research tool for assessing the effectiveness of acupuncture treatments in a real-world setting. The study aimed to provide a comprehensive methodological analysis of PATs using the PRagmatic Explanatory Continuum Indicator Summary-2 (PRECIS-2) tool to determine their pragmatism.
Methods
The MEDLINE, EMBASE, Cochrane Central Register for Controlled Trials, CINAHL, Allied and Complementary Medicine Database (AMED), China National Knowledge Infrastructure, VIP, WANFANG, Taiwan Periodical Literature Database, KoreaMed, KMbase, Research Information Service System, Oriental Medicine Advanced Searching Integrated System, CiNii and ClinicalTrials.gov were searched. The search included randomised clinical trials (RCTs) and protocols of RCTs that investigated all types of acupuncture and used self-declared pragmatic design. Two authors independently collected the basic information and characteristics of the studies and assessed their pragmatism using the nine PRECIS-2 domains and one additional domain - control.
Results
A total of 93 studies were included. The means of eligibility, recruitment, organisation, primary outcome, primary analysis, and control domains were statistically larger than three and were shown to be pragmatic. The means of setting, flexibility:delivery, and follow-up domains were not greater than three and were shown to be non-pragmatic. For flexibility:adherence domain was inappropriate for assessment owing to insufficient information in the studies.
Conclusions
Future PATs need to strengthen the pragmatism in the setting, flexibility:delivery, and follow-up domains and to describe the flexibility:adherence domain in more detail.
Systematic review registration
CRD42021236975
Effect of early and delayed umbilical cord clamping on placental transfusion in two-step delivery: a randomised clinical trial
Authors: Zanardo Vincenzo , Guerrini Pietro , Tortora Domenico , Severino Lorenzo , Sandri Andrea , Strafece Gianluca 
Published: May 2023

Abstract
Objective To investigate the effect of ‘two-step’ delivery and early (ECC) or delayed cord clamping (DCC) on placental transfusion in term infants.Methods Randomised clinical trial (NCT04459442). 90 infants were randomised to ECC (at 1 minute) or DCC (at 3 minutes) before two-step delivery wherein 83 (39 with ECC and 44 with DCC) received the allocated intervention. The primary outcome was the placental transfusion defined by ∆ haematocrit (Hct) from cord blood at birth and capillary heel blood at 48 h of age, accounting for body weight decrease, with the power estimate based on haematocrit (Hct) levels, in ECC and DCC neonate groups. The secondary outcomes were the contemporary readings of arterial cord blood gases, lactate, and glucose.Results It was found that Hct levels, comparable at birth between neonates who underwent ECC or DCC (49.501 ± 0.909 vs 48.764 ± 0.824, p 0.551), were significantly increased at 48 hours of age in the DCC group (50.778 ± 1.102 vs 55.051 ± 0.979, p 0.0051) representing a significantly higher ∆ Hct (1.278 ± 5.29 vs 6.287 ± 0.998, p 0.011) despite a comparable body weight decrease, all pointing to a higher placental transfusion in the DCC group, presenting with an acid–base and metabolic equilibrium.Conclusion In term infants born by ’two-step’ delivery, DCC results in a higher blood volume in the newborn and facilitates the maternal–placental–foetal exchange of circulating compounds, without potentially detrimental neonatal outcomes.
Gut microbiota of Suncus murinus, a naturally obesity-resistant animal, improves the ecological diversity of the gut microbiota in high-fat-diet-induced obese mice
Authors: Yi Shuang-Qin , Zhang Mingshou , Yang Ting , Li Rujia , Ren Ke , Li Jun , He Maozhang , Uetake Shunichi , Chen Juefei 
Published: May 2023

Abstract
Objective:
The global population of obese individuals is increasing, affecting human health. High-fat diets are a leading cause of this epidemic, and animal models, such as mice, are often used in related research. Obese individuals have a different gut microbiota composition from non-obese ones, characterized by a sizeable population of certain bacteria associated with fat storage. The gut microbiome plays a significant role in regulating human physiological and metabolic functions. Links between obesity, high-fat diets and gut microbiota have become hot topics of discussion. Recently, research on the modulation of the gut microbiota has focused on fecal microbiota transplantation, which has been recognized as an effective method of studying the function of gut microbiota.
Methods:
In this study, the naturally obesity-resistant animal Suncus murinus was used as a donor for fecal microbiota transplantation (FMT). C57BL/6NCrSIc mice were used as recipients, and changes in their gut flora were analyzed using a 16S rRNA gene analysis.
Results:
The study found that, after the FMT procedure, the FMT group tended to have a lower body weight than the control group. At the phylum level, the most predominant phyla in all groups were Firmicutes and Proteobacteria, while Deferribacteres was not detected in the FMT or antibiotic administration groups, and Bacteroidetes was not present in the antibiotic administration group. At the genus level, the FMT group had significantly lower OTU richness than the control group but greater diversity than the control group.
Conclusion:
These results indicate that FMT from Suncus murinus can help reorganize and improve the gut microbiota of mice in a balanced and diverse ecosystem.