bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sources of prey availability data alter interpretation of outputs from prey choice null networks
Authors: Cuff Jordan P. , Tercel Maximillian P.T.G. , Windsor Fredric M. , Hawthorne Ben S.J. , Hambäck Peter A. , Bell James R. , Symondson William O.C. , Vaughan Ian P. 
Published: July 2023

AbstractNull models provide an invaluable baseline against which to test fundamental ecological hypotheses and highlight patterns in foraging choices that cannot be explained by neutral processes or sampling artefacts. In this way, null models can advance our understanding beyond simplistic dietary descriptions to identify drivers of interactions. This method, however, requires estimates of resource availability, which are generally imperfect representations of highly dynamic systems. Optimising method selection is crucial for study design, but the precise effects of different resource availability data on the efficacy of null models are poorly understood.Using spider-prey networks as a model, we used prey abundance (suction sample) and activity density (sticky trap) data, and combinations of the two, to simulate null networks. We compared null diet composition, network properties (e.g., connectance and nestedness) and deviations of simulations from metabarcoding-based spider dietary data (to ascertain how different prey availability data alter ecological interpretation.Different sampling methods produced different null networks and inferred distinct prey selectivity. Null networks based on prey abundance and combined frequency-of-occurrence data more closely resembled the observed diet composition, and those based on prey abundance, activity density and proportionally combined data generated network properties most like dietary metabarcoding networks.We show that survey method choice impacts all aspects of null network analyses, the precise effects varying between methods but ultimately altering ecological interpretation by increasing disparity in network properties or trophic niches between null and directly constructed networks. Merging datasets can generate more complete prey availability data but is not a panacea because it introduces different biases. The choice of method should reflect the research hypotheses and study system being investigated. Ultimately, survey methods should emulate the foraging mode of the focal predator as closely as possible, informed by the known ecology, natural history and behaviour of the predator.
A genomic exploration of the possible de-extirpation of the Zanzibar leopard
Authors: Sun Xin , Cavill Emily Louisa , Margaryan Ashot , Lin Jianqing , Thingaard Søren , Said Tamrini A. , Gopalakrishnan Shyam , Gilbert M. Thomas P. 
Published: July 2023

SummaryThe recently extirpated Zanzibar leopard was the only known African leopard (Panthera pardus spp.) population restricted exclusively to a major island habitat. Although its demise was driven through habitat change and conflict with humans, given its role as a keystone species for the Zanzibar Archipelago, its potential reintroduction might offer a means for helping preserve the natural biodiversity of its former habitat. Whether this is feasible, however, would be contingent on both whether closely related source populations can be identified on mainland Africa, and whether the Zanzibar form exhibited any special adaptations that might need to be considered when choosing such a source. In light of these questions, we genomically profiled two of the six known historic specimens, to explore whether they represent a realistic candidate for de-extirpation through reintroduction. Our analyses indicate that despite its geographic separation, the Zanzibar leopard shared a close genetic relationship with mainland East African individuals. Furthermore, although its uniqueness as an island population was emphasised by genomic signatures of high inbreeding and increased mutation load, the latter similar to the level of the critically endangered Amur leopard (P. p. orientalis), we find no evidence of positive selection unique to Zanzibar. We therefore conclude that should attempts to restore leopards to Zanzibar be planned, then mainland East African leopards would provide a suitable gene pool, whether using genetic engineering or conventional rewilding approaches.
Massively Concurrent Sub-Cellular Traction Force Videography enabled by Single-Pixel Optical Tracers (SPOTs)
Authors: Marvin Tan Xing Haw , Wang Yijie , Zhu Xiongfeng , Mendes Felipe Nanni , Chung Pei-Shan , Chow Yu Ting , Man Tianxing , Lan Hsin , Lin Yen-Ju , Zhang Xiang , Zhang Xiaohe , Nguyen Thang , Ardehali Reza , Teitell Michael A. , Deb Arjun , Chiou Pei-Yu 
Published: July 2023

AbstractWe report a large field-of-view and high-speed videography platform for measuring the sub-cellular traction forces of more than 10,000 biological cells over 13mm2at 83 frames per second. Our Single-Pixel Optical Tracers (SPOT) tool uses 2-dimensional diffraction gratings embedded into a soft substrate to convert cells’ mechanical traction stress into optical colors detectable by a video camera. The platform measures the sub-cellular traction forces of diverse cell types, including tightly connected tissue sheets and near isolated cells. We used this platform to explore the mechanical wave propagation in a tightly connected sheet of Neonatal Rat Ventricular Myocytes (NRVMs) and discovered that the activation time of some tissue regions are heterogeneous from the overall spiral wave behavior of the cardiac wave.One-Sentence SummaryAn optical platform for fast, concurrent measurements of cell mechanics at 83 frames per second, over a large area of 13mm2.
Local Disordered Region Sampling (LDRS) for Ensemble Modeling of Proteins with Experimentally Undetermined or Low Confidence Prediction Segments
Authors: Liu Zi Hao , Teixeira João M.C. , Zhang Oufan , Tsangaris Thomas E. , Li Jie , Gradinaru Claudiu C. , Head-Gordon Teresa , Forman-Kay Julie D. 
Published: July 2023

STRUCTURED ABSTRACTSUMMARYThe Local Disordered Region Sampling (LDRS, pronouncedloaders) tool, developed for the IDPConformerGenerator platform (Teixeiraet al. 2022), provides a method for generating all-atom conformations of intrinsically disordered regions (IDRs) at N- and C-termini of and in loops or linkers between folded regions of an existing protein structure. These disordered elements often lead to missing coordinates in experimental structures or low confidence in predicted structures. Requiring only a pre-existing PDB structure of the protein with missing coordinates or with predicted confidence scores and its full-length primary sequence, LDRS will automatically generate physically meaningful conformational ensembles of the missing flexible regions to complete the full-length protein. The capabilities of the LDRS tool of IDPConformerGenerator include modeling phosphorylation sites using enhanced Monte Carlo Side Chain Entropy (MC-SCE) (Bhowmick and Head-Gordon 2015), transmembrane proteins within an all-atom bilayer, and multi-chain complexes. The modeling capacity of LDRS capitalizes on the modularity, ability to be used as a library and via command-line, and computational speed of the IDPConformerGenerator platform.AVAILABILITY AND IMPLEMENTATIONThe LDRS module is part of the IDPConformerGenerator modeling suite, which can be downloaded from GitHub athttps://github.com/julie-forman-kay-lab/IDPConformerGenerator. IDPConformerGenerator is written in Python and works on Linux, Microsoft Windows, and Mac OS versions that support DSSP. Users can utilize LDRS’s Python API for scripting the same way they can use any part of IDPConformerGenerator’s API, by importing functions from the ‘idpconfgen.ldrs_helper’ library. Otherwise, LDRS can be used as a command line interface application within IDPConformerGenerator. Full documentation is available within the command-line interface (CLI) as well as on IDPConformerGenerator’s official documentation pages (https://idpconformergenerator.readthedocs.io/en/latest/).CONTACTFor support with LDRS please contact Zi Hao (Nemo) Liu vianemo.liu@sickkids.caor submit an issue in the IDPConformerGenerator repository on GitHub (https://github.com/julie-forman-kay-lab/IDPConformerGenerator/issues).SUPPLEMENTARY INFORMATIONThe supplementary information document contains, or links to, all the conformer ensembles generated for this publication, the generalized Python scripts using the LDRS Python API, figures of detailed methods, fractional secondary structure information, torsion angle sampling, and the time required to generate the different protein cases.
Chemoproteomics reveals the epoxidase enzyme for the biosynthesis of camptothecin precursor strictosamide epoxide
Authors: Zhang Tong , Wang Yan , Wu Shiwen , Tian Ernuo , Yang Chengshuai , Zhou Zhihua , Yan Xing , Wang Pingping 
Published: July 2023

AbstractCamptothecin and its derivatives are the third largest anticancer drugs in the world market, mainly used to treat malignant tumors such as lung, colon and cervical cancer. Camptothecin was firstly discovered inCamptotheca acuminateand extracted mainly fromC. acuminateandNothapodytes nimmonianafor medicine production (Sadre et al. 2016). However, the overharvesting ofC. acuminateandN. nimmonianahas greatly reduced their populations in nature, which are currently listed as the second protected plants in China and India. It is estimated there would be 20 million new cancer cases in 2025 all over the world, meeting the growing demand for camptothecin and other anti-cancer drugs has become a daunting challenge (Seca et al. 2018). In this study we tried to elucidate the unknown biosynthetic pathway from strictosamide1to strictosamide epoxide2by unearthing the candidate enzymes from the proteome of plantOphiorrhiza pumilausing the chemoproteomic strategy.
Co-opted cytosolic host proteins form unique condensate substructures within the membranous tombusviral replication organelles
Authors: Lin Wenwu , Nagy Peter D. 
Published: July 2023

AbstractPositive-strand RNA viruses co-opt intracellular organellar membranes for the biogenesis of viral replication organelles (VROs). The membranous VROs are the sites of viral replication. Tombusviruses co-opt numerous host proteins, many of them cytosolic, not membrane-bound, such as the glycolytic and fermentation enzymes. It is currently not known what type of molecular organization keeps these enzymes enriched and sequestered within the membranous VROs. Here, we show evidence that the tomato bushy stunt virus (TBSV) p33 and the closely-related carnation Italian ringspot virus (CIRV) p36 replication proteins sequester several co-opted cytosolic proteins in unique condensate substructures associated with the membranous VROs. We find that TBSV p33 and CIRV p36 replication proteins form dropletsin vitroorganized by their intrinsically disordered region (IDR). The replication proteins also organize the partitioning of several co-opted host proteins to p33/p36 droplets. We also show that the VRO-associated condensates containing co-opted glycolytic and fermentation enzymes are critical for local ATP production within the VRO to support the energy need of virus replication. A short segment with charged amino acids in p33/p36 IDR plays a critical role in droplet formationin vitro, in organizing the VRO-associated condensates and affects both ATP production in VROs and viral replication. We find that the co-opted ER membranes and actin filaments form meshworks within and around the condensate, likely contributing to the unique composition and structure of VROs. We propose that the p33/p36 replication proteins organize liquid-liquid phase separation of co-opted highly concentrated host proteins in condensate substructures within VROs to allow for the dynamic regulation of viral replication. Overall, we demonstrate that distinct substructures co-exist in tombusvirus VROs. These are the subverted membranes and condensate substructures, both of which are critical for VRO functions. The p33/p36 replication proteins induce and connect the two substructures within the VROs. Interfering with condensate formation in VROs might open up new antiviral approaches.
Applicability of lean maintenance in commercial high-rise buildings: a case study in Sri Lanka
Authors: Arsakulasooriya Kavindu Kanishka , Sridarran Pournima , Sivanuja Thirumal 
Published: July 2023

Purpose
Compared to low-rise and mid-rise buildings, commercial high-rise buildings have severe maintenance management deficiencies due to the complex nature of the structure and building services incorporated. Previous studies have shown that implementing lean in maintenance is a recognised prominent strategy to enhance maintenance performance. Thus, this study aims to investigate how lean maintenance can be applied to improve maintenance management in commercial high-rise buildings in Sri Lanka.

Design/methodology/approach
This study adopted a case study method. Three commercial high-rise buildings were selected to conduct the empirical study. An expert survey is also conducted to validate the findings.

Findings
The findings of the study revealed that out of the eight cardinal types of lean maintenance waste, six are rooted in the selected cases: (i) excessive preventive maintenance, (ii) waiting (maintenance resources, tools, procuring of additional supplies and documentation and permits), (iii) transportation due to centralised maintenance, (iv) poor inventory management, (v) poor information handling and (vi) poor utilisation of labour. Then the study revealed strategies to eradicate identified lean maintenance wastes.

Practical implications
The findings of this study can be used to guide maintenance practitioners in implementing lean maintenance in Sri Lankan commercial high-rise buildings. Furthermore, the proposed strategies can be directly applied to mitigate identified maintenance wastes.

Originality/value
This paper provides information on how high-rise commercial buildings in Sri Lanka can enhance their maintenance management by mitigating lean maintenance wastes.
Thermal enhancement of nano-fluidic transport confined between disk and cone both rotating with distinct angular velocities and heat transfer
Authors: Maraj E.N. , Akbar Noreen Sher , Kousar Nabeela , Zehra Iffat , Muhammad Taseer 
Published: July 2023

Purpose
This paper aims to study the fluid flow and heat transfer within the Casson nanofluid confined between disk and cone both rotating with distinct velocities. For a comprehensive investigation, two distinct nano-size particles, namely, silicon dioxide and silicon carbide, are submerged in ethanol taken as the base fluid.

Design/methodology/approach
This paper explores the disk and cone contraption mostly encountered for viscosity measurement in various industrial applications such as lubrication industry, hydraulic brakes, pharmaceutical industry, petroleum and gas industry and chemical industry.

Findings
It is worth mentioning here that the radially varying temperature profile at the disk surface is taken into the account. The effect of prominent emerging parameters on velocity fields and temperature distribution are studied graphically, while bar graphs are drawn to examine the physical quantities of industrial interest such as surface drag force and heat transfer rate at disk and cone.

Originality/value
To the best of the authors’ knowledge, no study in literature exists that discusses the thermal enhancement of nano-fluidic transport confined between disk and cone both rotating with distinct angular velocities with heat transfer.
Nurturing the soul at work: unveiling the impact of spiritual leadership, interpersonal justice and voice behavior on employee intention to stay
Authors: Aboobaker Nimitha , K.A. Zakkariya 
Published: July 2023

Purpose
This study investigates how the spiritual leadership style of a manager affects employees' intention to stay with the organization, taking into account the post-pandemic workplace and the expected economic downturn. Furthermore, this study aims to assess how employee voice behavior mediates the linkages between the spiritual leadership style and intention to stay and how this mediation is influenced by perceived interpersonal justice. Grounded on the self-determination theory of intrinsic motivation and social-exchange theory, this study seeks to advance the theoretical understanding of spiritual leadership and its associated outcomes.

Design/methodology/approach
The descriptive study included 379 frontline employees in India's tourism and hospitality sector. Responses were collected from selected employees using the snowball sampling method and met strict inclusion criteria. Self-reporting questionnaires were used to collect data from the participants. Confirmatory factor analysis was conducted using IBM AMOS 21.0, and hypothesis testing and drawing inferences were carried out using path analytic procedures with PROCESS Macro 3.0.

Findings
Consistent with the hypotheses presented in this paper, this study demonstrated a statistically significant indirect impact of spiritual leadership on employees' intention to stay with the organization, through indirect effects of employee voice behavior. Additionally, the conditional indirect effects of spiritual leadership on employees' intention to stay, mediated by voice behavior, were contingent upon the level of interpersonal justice as a moderator. Specifically, these effects were significant when the levels of interpersonal justice were low but not when they were high.

Originality/value
This study makes significant strides in developing and testing a pioneering model that examines the association between spiritual leadership and employees’ intention to stay with the organization. This research explores explicitly how this relationship is influenced by perceived interpersonal justice and employee voice behavior. The results of this study emphasize the criticality of cultivating a culture that inspires constructive criticism and elucidates its potential advantages, effectively bridging a gap in the existing scholarly literature.
What factors are associated with public corruption perception? Evidence from Canada
Authors: Asomah Joseph Yaw , Dim Eugene Emeka , Li Yiyan , Cheng Hongming 
Published: July 2023

Purpose
Corruption perception is essential to study because it can shape people’s attitudes toward the government. Thus, the purpose of this paper is to address this key question: what factors are associated with a non-expert’s judgment of whether Canada is corrupt?

Design/methodology/approach
This study uses the World Value Survey conducted in Canada in October 2020. This survey is based on a nationally representative sample of a cross-section of adult Canadian residents, including Canadian citizens and permanent residents and those who are neither Canadian citizens nor permanent residents.

Findings
Based on this study, some conclusions can be made. First, people accessing corruption news from the traditional news media are less likely than those receiving information from the new media to perceive the state (in this case, Canada) as corrupt. Second, people who have less confidence in public institutions are more likely to perceive a country as corrupt. Third, people who participate in electoral and non-electoral forms of political participation are more likely to perceive the state and its public officials as corrupt. Fourth, regardless of which political party is in power, individuals who lean right politically are more likely than those on the left to perceive the state as corrupt. Finally, immigrants are less likely than those born in Canada to perceive the state as corrupt. This work enriches the literature on the substantive understanding of the factors associated with corruption perception.

Originality/value
Studies investigating factors associated with public perception of corruption tend to focus on developing countries. The current study contributes to filling this gap in knowledge by examining correlates of corruption perception in Canada. As a result, this study contributes to the literature on factors associated with corruption perception, especially in the developed country context.
Meta‐analysis of effectiveness and safety of glucocorticoid combined with hydroxychloroquine in the treatment of systemic lupus erythematosus rash
Authors: Liang Siping , Wei Zhiming , Fang Hanjun , Guan Tong 
Published: July 2023

AbstractBackgroundMany studies have found that glucocorticoid (GC) combined with hydroxychloroquine (HCQ) has a good clinical effect in the treatment of systemic lupus erythematosus (SLE) rash, but there is no relevant systematic evaluation at present. The purpose of this study was to systematically evaluate and analyze the effectiveness and safety of GC combined with HCQ in the treatment of SLE rash.MethodsRandomized controlled trials of GC combined with HCQ in the treatment of SLE rash were collected through computer retrieval of Cochrane Library, PubMed, Embase, CNKI, China Science and Technology Journal Database (VIP), Wanfang Data Knowledge Service Platform (Wanfang), and China Biology Medicine disc (CBM) since the establishment of the database. The main outcome indicators included clinical total effective rate, adverse reactions, SLE disease activity index (SLEDAI) score, erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP), and complement 3 (C3). A meta‐analysis was conducted using Review Manager 5.3 software.ResultsA total of 11 studies involving 809 patients (406 in the test group and 403 in the control group) were included in this article. The meta‐analysis results showed that compared with the single use of GC, GC combined with HCQ could improve the clinical total effective rate in the treatment of SLE rash (odds ratio [OR] = 4.27, 95% confidence interval [CI] 2.50–7.30, p < .00001), and reduce the occurrence of adverse reactions (OR = 0.26, 95% CI 0.15–0.44, p < .00001); effectively reduce SLEDAI score (mean difference [MD] = 1.88, 95% CI 1.66–2.10, p < .00001) and ESR level (MD = 7.92, 95% CI 5.66–10.19, p < .00001); increase C3 level after treatment (MD = 0.36, 95% CI 0.32–0.41, p < .00001); and reduce CRP level (MD = 3.22, 95% CI 2.87–3.58, p < .00001), with statistically significant differences.ConclusionCompared with the use of GC alone, GC combined with HCQ can improve the clinical effectiveness of SLE rash treatment, with a low incidence of adverse reactions and good clinical safety. However, the number and quality of studies included in this article were not high, so the findings need to be further verified by high‐quality, multicenter randomized controlled trials.
Classifying the degree of cooperative multinationality: Case study of a French multinational cooperative
Authors: Errasti Anjel , Bretos Ignacio , Marcuello Carmen 
Published: July 2023

AbstractIn recent decades, the largest European worker cooperatives, and those that are the most emblematic in their countries, have been transformed into multinational companies. This article examines workers’‐cooperative multinationality by providing a classifying tool based on the interaction between control rights and return rights held by foreign employees in the subsidiaries of multinational cooperatives. We illustrate our matrix of cooperative multinationality by classifying an internationalized historical cooperative, Up Group (formerly Chèque Déjeuner, SCOP). In the last few decades, the French cooperative Up has become a hybrid multinational player in the employee benefits industry by setting up capitalist subsidiaries both in France and overseas. The case study also reports on Up's innovative attempt to produce a global cooperative or a more democratic multinational enterprise through converting subsidiaries’ employees into associates.
Editorial: Recognising the regional variations in profile of irritable bowel syndrome—better late than never!
Authors: Ghoshal Uday C. 
Published: July 2023

LINKED CONTENTThis article is linked to Chuah et al papers. To view these articles, visit https://doi.org/10.1111/apt.17567 and https://doi.org/10.1111/apt.17634