bluuebunny/crossref_metadata_2025_split huggingface dataset:
Partner-developed electronic health record tools to facilitate social risk-informed care planning
Authors: Gunn Rose , Pisciotta Maura , Gold Rachel , Bunce Arwen , Dambrun Katie , Cottrell Erika K , Hessler Danielle , Middendorf Mary , Alvarez Miguel , Giles Lydia , Gottlieb Laura M 
Published: February 2023

AbstractObjectiveIncreased social risk data collection in health care settings presents new opportunities to apply this information to improve patient outcomes. Clinical decision support (CDS) tools can support these applications. We conducted a participatory engagement process to develop electronic health record (EHR)-based CDS tools to facilitate social risk-informed care plan adjustments in community health centers (CHCs).Materials and MethodsWe identified potential care plan adaptations through systematic reviews of hypertension and diabetes clinical guidelines. The results were used to inform an engagement process in which CHC staff and patients provided feedback on potential adjustments identified in the guideline reviews and on tool form and functions that could help CHC teams implement these suggested adjustments for patients with social risks.ResultsPartners universally prioritized tools for social risk screening and documentation. Additional high-priority content included adjusting medication costs and changing follow-up plans based on reported social risks. Most content recommendations reflected partners’ interests in encouraging provider–patient dialogue about care plan adaptations specific to patients’ social needs. Partners recommended CDS tool functions such as alerts and shortcuts to facilitate and efficiently document social risk-informed care plan adjustments.Discussion and ConclusionCDS tools were designed to support CHC providers and staff to more consistently tailor care based on information about patients’ social context and thereby enhance patients’ ability to adhere to care plans. While such adjustments occur on an ad hoc basis in many care settings, these are among the first tools designed both to systematize and document these activities.
A high-quality reference genome of the kelp surfperch, Brachyistius frenatus (Embiotocidae), a wide-ranging Eastern Pacific reef fish with no pelagic larval stage
Authors: Toy Jason A , Bernardi Giacomo 
Published: February 2023

Abstract
The surfperches (family Embiotocidae) are a unique group of mostly marine fishes whose phylogenetic position within the Ovalentaria clade (Percomorpha) is still unresolved. As a result of their viviparity and lack of a dispersive larval stage, surfperches are an excellent model for the study of speciation, gene flow, and local adaptation in the ocean. They are also the target of an immensely popular recreational fishery. Very few high-quality molecular resources, however, are available for this group and only for a single species. Here, we describe a highly complete reference genome for the kelp surfperch, Brachyistius frenatus, assembled using a combination of short-read (Illumina, ~47× coverage) and long-read (Oxford Nanopore Technologies, ~27× coverage) sequencing. The 596 Mb assembly has a completeness level of 98.1% (BUSCO), a contig N50 of 2.6 Mb (n = 56), and a contig N90 of 406.6 kb (n = 293). Comparative analysis revealed a high level of synteny between B. frenatus and its close relative, Embiotoca jacksoni. This assembly will serve as a valuable molecular resource upon which future evolutionary dynamics research will build, such as the investigation of local adaptation and the genomic potential for climate adaptation in wild populations.
Jasmonate: the Swiss army knife in the plant’s pocket
Authors: Zhu Ziqiang 
Published: February 2023

AbstractJasmonate is a well-known defence hormone for plants, but it is also necessary for growth and development. Indeed, the identification of the COI1 receptor was based on the jasmonate-triggered response of root growth inhibition. In this special issue, a collection of review papers and two research papers discuss the current state of progress in this field, covering areas from seed germination and flowering to the Jasminum sambac genome.
SHIMM: a versatile seeing monitor for astronomy
Authors: Perera Saavidra , Wilson Richard W , Butterley Tim , Osborn James , Farley Ollie J D , Laidlaw Douglas J 
Published: February 2023

ABSTRACTCharacterization of atmospheric optical turbulence is crucial for the design and operation of modern ground-based optical telescopes. In particular, the effective application of adaptive optics correction on large and extremely large telescopes relies on a detailed knowledge of the prevailing atmospheric conditions, including the vertical profile of the optical turbulence strength and the atmospheric coherence time-scale. The Differential Image Motion Monitor (DIMM) has been employed as a facility seeing monitor at many astronomical observing sites across the world for several decades, providing a reliable estimate of the seeing angle. Here, we present the Shack–Hartmann Image Motion Monitor (SHIMM), which is a development of the DIMM instrument, in that it exploits differential image motion measurements of bright target stars. However, the SHIMM employs a Shack–Hartmann wavefront sensor in place of the two-hole aperture mask utilized by the DIMM. This allows the SHIMM to provide an estimate of the seeing, unbiased by shot noise or scintillation effects. The SHIMM also produces a low-resolution (three-layer) measure of the vertical turbulence profile, as well as an estimate of the coherence time-scale. The SHIMM is designed as a low-cost, portable instrument. It is comprised of off-the-shelf components so that it is easy to duplicate and well suited for comparisons of atmospheric conditions within and between different observing sites. Here, the SHIMM design and methodology for estimating key atmospheric parameters will be presented, as well as initial field test results with comparisons to the Stereo-SCIntillation Detection And Ranging instrument.
The efficacy of genotype-based dietary or physical activity advice in changing behavior to reduce the risk of cardiovascular disease, type II diabetes mellitus or obesity: a systematic review and meta-analysis
Authors: King Alexandra , Graham Catherine A -M , Glaister Mark , Da Silva Anastacio Viviane , Pilic Leta , Mavrommatis Yiannis 
Published: February 2023

Abstract

Context
Despite clear evidence that adherence to dietary and physical activity advice can reduce the risk of cardiometabolic disease, a significant proportion of the population do not follow recommendations. Personalized advice based on genetic variation has been proposed for motivating behavior change, although research on its benefits to date has been contradictory.

Objective
To evaluate the efficacy of genotype-based dietary or physical activity advice in changing behavior in the general population and in individuals who are at risk of cardiovascular disease (CVD) or type II diabetes mellitus (T2DM).

Data Sources
MEDLINE, EMBASE, PsycInfo, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched up to January 7, 2022. Randomized controlled trials of a genotype-based dietary and/or physical activity advice intervention that aimed to change dietary and/or physical activity behavior were included.

Data Extraction
Abstracts of 7899 records were screened, and 14 reports from 11 studies met the inclusion criteria.

Data Analysis
Genotype-based dietary or physical activity advice was found to have no effect on dietary behavior in any of the studies (standardized mean difference [SMD] .00 [–.11 to .11], P = .98), even when analyzed by subgroup: “at risk” (SMD .00 [–.16 to .16, P = .99]; general population (SMD .01 [–.14 to .16], P = .87). The physical activity behavior findings were similar for all studies (SMD –.01 [–.10 to .08], P = .88), even when analyzed by subgroup: “at risk” (SMD .07 [–.18 to .31], P = .59); general population (SMD –.02 [–.13 to .10], P = .77). The quality of the evidence for the dietary behavior outcome was low; for the physical activity behavior outcome it was moderate.

Conclusions
Genotype-based advice does not affect dietary or physical activity behavior more than general advice or advice based on lifestyle or phenotypic measures. This was consistent in studies that recruited participants from the general population as well as in studies that had recruited participants from populations at risk of CVD or T2DM.

Systematic Review Registration
PROSPERO registration no. CRD42021231147.
Lipid profile and risk of cardiovascular disease in adult transgender men receiving cross-sex hormone therapy: a systematic review
Authors: Quintela-Castro Fernanda Cristina de Abreu , Pereira Taísa Sabrina Silva , Alves Danúbia Boy , Chiepe Letícia , Nascimento Laura Sperandio , Chiepe Kelly Cristina Mota Braga , Barcelos Rafael Mazioli , Costa Bruno Maia , Enriquez-Martinez Oscar Geovanny , Rossoni Joamyr Victor , Bellettini-Santos Tatiani 
Published: February 2023

Abstract

Context
A recent US national survey of the health status of the male transgender population has raised awareness about the little-studied relationship between testosterone hormone therapy in transgender men and cardiovascular outcomes.

Objective
The aim of this systematic review was to assess the relationship between cross-sex hormone therapy in transgender men and lipid profiles and cardiovascular risk.

Data Sources
The PubMed, SciELO, SpringerLink, and EBSCOhost databases were searched up to March 2021 for studies assessing the association between cross-sex hormone therapy and the incidence of outcomes related to cardiovascular disease in transgender men over 18 years of age .

Data Extraction
Data extracted were sorted into clinical data (systolic, diastolic, and mean blood pressure), anthropometric data (body mass index, weight, waist circumference, fat mass, and lean mass), and biochemical data (triglycerides, total cholesterol, low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], very low-density lipoprotein cholesterol [VLDL-C], and the HDL-C to LDL-C ratio).

Data Analysis
Study quality was appraised independently by two reviewers using the Cochrane tools for assessment of methodological quality or risk of bias in nonrandomized studies, and the Newcastle-Ottawa Scale was applied. Of 735 studies identified, 11 were included in the review. Most studies reported no change in cholesterol or triglyceride levels after hormone treatment. A reduction in HDL-C levels was observed in 7 of 11 studies, although this alone cannot be considered a cardiovascular risk factor. Likewise, clinical and anthropometric findings showed no changes predictive of cardiovascular risk.

Conclusions
Although these findings suggest that hormone therapy may lead to a decrease in HDL-C levels and an increase in LDL-C levels, they are insufficient to establish a relationship with cardiovascular disease. Furthermore, no significant effects on metabolic and anthropometric values were found. Further studies with higher quality and longer follow-up periods are needed to establish cardiovascular risk.

Systematic Review Registration
PROSPERO registration number CRD 42020212560.
Radiation-supported new-type tori in the Newtonian and logarithmic potentials
Authors: Fukue Jun , Fukue Tsubasa , Fukue Kei 
Published: February 2023

Abstract
We examine radiation-supported rotating tori in the Newtonian and logarithmic potentials, using the similarity method, and analytically find new-type self-similar solutions of astrophysical tori for both cases. In the Newtonian case around a central point mass, radiative quantities such as fluxes and energy density are expressed in a simple form, although the expression for the gas density is somewhat complicated. It is noted that the gaseous configuration in the Newtonian (point-mass) case has a conical surface, where the radiation energy density vanishes. In the logarithmic case in, e.g., dark matter, on the other hand, simple analytical solutions for matter and radiation distributions are obtained. In the logarithmic case, furthermore, the gaseous configuration extends over the whole space, if it exists. In both cases, the density contours have toroidal shapes, and elongate in the equatorial direction due to rotation.
A proper headache: trust drafting and the proper purpose rule after Grand View v Wong
Authors: McPhail Tom 
Published: February 2023

Abstract
The decision of the Board of the Privy Council in Grand View v Wong has given much greater prominence to the proper purpose rule in the context of the exercise by trustees of their powers. This article argues that, while the apparent desire of the Board to control abuse of trust arrangements is understandable, the judgment risks undermining trustee decision-making and encouraging litigation and unnecessary court applications.
Unplanned Readmission Is Associated With Decreased Overall Survival and Performance After Metastatic Spine Surgery
Authors: Chanbour Hani , Chen Jeffrey W. , Gangavarapu Lakshmi S. , Bendfeldt Gabriel A. , LaBarge Matthew E. , Ahmed Mahmoud , Roth Steven G. , Chotai Silky , Luo Leo Y. , Abtahi Amir M. , Stephens Byron F. , Zuckerman Scott L. 
Published: February 2023

Study Design.
Retrospective case-control study.

Objective.
In a cohort of patients undergoing metastatic spine surgery, we sought to: (1) identify risk factors associated with unplanned readmission, and (2) determine the impact of an unplanned readmission on long-term outcomes.

Summary of Background Data.
Factors affecting readmission after metastatic spine surgery remain relatively unexplored.

Materials and Methods.
A single-center, retrospective, case-control study was undertaken of patients undergoing spine surgery for extradural metastatic disease between 02/2010 and 01/2021. The primary outcome was 3-month unplanned readmission. Preoperative, perioperative, and tumor-specific variables were collected. Multivariable Cox regression was performed, controlling for tumor size, other organ metastasis, and preoperative/postoperative radiotherapy/chemotherapy.

Results.
A total of 357 patients underwent surgery for spinal metastases with a mean follow-up of 538.7±648.6 days. Unplanned readmission within 3 months of surgery occurred in 64/357 (21.9%) patients, 37 (57.8%) were medical, 27 (42.2%) surgical, and 21 (77.7%) were related to their spine surgery. No significant differences were found regarding demographics and preoperative variables, except for insurance, where most readmitted patients had private insurance compared with nonreadmitted patients (P=0.021). No significant difference was found in preoperative radiotherapy/chemotherapy. Regarding perioperative exposure variables, readmitted patients had a higher rate of postoperative complications (68.8% vs. 24.2%, P<0.001) and worse postoperative Karnofsky Performance Score (P=0.021) and Modified McCormick Scale (P=0.015) at the time of first follow-up. On multivariate logistic regression, postoperative complications were associated with increased readmissions (odds ratio=1.38, 95% CI=1.25–1.52, P<0.001). Regarding the impact of unplanned readmission on long-term tumor control, unplanned readmission was associated with shorter time to local recurrence (log-rank; P=0.029) and reduced overall survival (OS) (log-rank; P<0.001). On multivariate Cox regression, other organ metastasis [hazard ratio (HR)=1.48, 95% CI=1.13–1.93, P=0.004] and 3-month readmission (HR=1.75, 95% CI=1.28–2.39, P<0.001) were associated with worsened OS, with no impact on LR. Postoperative chemotherapy was significantly associated with longer OS (HR=0.59, 95% CI=0.45–0.77, P<0.001).

Conclusions.
Postoperative complications were associated with unplanned readmission following metastatic spine surgery. Furthermore, 3-month unplanned readmission was associated with a shorter time to local recurrence and decreased OS. These results help surgeons understand the drivers of readmissions and the impact of readmissions on patient outcomes.

Level of Evidence.
3.
BMI and Revision Surgery for Abdominoplasties: Complication Definitions Revisited Using the Clavien-Dindo Classification
Authors: Reischies Frederike M. J. , Tiefenbacher Fabian , Holzer-Geissler Judith C. J. , Wolfsberger Christina , Eylert Gertraud , Mischitz Madeleine , Pregartner Gudrun , Meikl Tobias , Winter Raimund , Kamolz Lars-Peter , Lumenta David B. 
Published: February 2023

Background:
After body contouring surgery of the lower trunk (CSLT), the definition, rate (4%–70%), and documentation of complications vary.

Objectives:
We analyzed the effect of risk factors on the outcome based on the Clavien-Dindo classification (CDC) after CSLT surgery and polled postoperative satisfaction among patients.

Methods:
All patients undergoing CSLT from 2001 to 2016 were included and were classified according to the CDC for postoperative events. Statistical analysis included proportional odds logistic regression analysis. We polled patients to grade their satisfaction with the postoperative result and whether they would have the operation performed again.

Results:
A total of 265 patients were included: 60 (22.6%), 25 (9.4%), 28 (10.6%), and 21 (7.9%) were in CDC grades I, II, IIIa, and IIIb, respectively. A high preoperative body mass index significantly increased the odds for a postoperative event requiring revision surgery under general anesthesia (CDC grade IIIb, odds ratio 0.93, 95% confidence interval 0.89–0.97, P = 0.001). One-hundred twenty-eight patients (48.3%) participated in the poll: 101 (78.9%) were either happy or content with the postoperative results, and 117 (91.4%) would have the procedure performed again, including all nine patients with CDC grade IIIb.

Conclusions:
Our results confirm that a high body mass index is a statistically significant risk factor for requiring major revision surgery after CSLT. Despite being a complication prone intervention, postoperative satisfaction after CSLT was ranked favorably in our sample. We recommend that the CDC be used in all surgical specialties to evaluate complications and permit future comparability of pooled data.
Surgical Technique for Targeted Muscle Reinnervation in Knee Disarticulation Amputation for Nonambulatory Patients
Authors: Felder John M. , Saoud Karim 
Published: February 2023

Summary:
Chronic neuropathic pain following major limb amputation has historically been difficult to treat. In patients undergoing lower extremity amputation, “preemptive” targeted muscle reinnervation (TMR) nerve transfers may be performed concurrently with the amputation to help mitigate the risk of chronic neuropathic postoperative pain. Despite clinical studies demonstrating efficacy of TMR in lower extremity amputations, few procedural descriptions have been written, and none have been written regarding performing TMR at the knee disarticulation (KD) level of amputation. Although uncommonly utilized, the KD amputation has clear functional benefits over other levels of amputation for nonambulatory patients. As nonambulatory patients are also subject to the occurrence of chronic neuropathic postamputation pain, it stands to reason that the addition of TMR to KD surgery could be an improvement to standard techniques. In this report, we provide a technical description for concurrent TMR with KD and describe the rationale for its use.
Sleep irregularity and the association with hypertension and blood pressure levels: the ELSA-Brasil study
Authors: Parise Barbara K. , Santos Ronaldo B. , Mesas Arthur E. , Silva Wagner A. , Giatti Soraya , Aielo Aline N. , Cunha Lorenna F. , Souza Silvana P. , Bortolotto Luiz A. , Griep Rosane H. , Lotufo Paulo A. , Bensenor Isabela M. , Drager Luciano F. 
Published: February 2023

Objective:
To evaluate the associations of sleep irregularity with hypertension (HTN) and blood pressure (BP) levels.

Methods:
Adult participants from the ELSA-Brasil performed a clinical evaluation including objective sleep duration (actigraphy), insomnia, and a sleep study for defining obstructive sleep apnoea (OSA). To quantify sleep irregularity, we used two parameters obtained through actigraphy: 7-day standard deviation (SD) of sleep duration and 7-day SD of sleep-onset timing. A multivariate analysis was used to determine the independent associations of sleep irregularity with HTN and SBP/DBP values.

Results:
We studied 1720 participants (age 49 ± 8 years; 43.4% men) and 27% fulfilled the HTN diagnosis. After adjustments for age, gender, race, BMI, excessive alcohol consumption, physical activity intensity, urinary sodium excretion, insomnia, objective sleep duration and OSA (apnoea–hypopnoea index ≥15 events/h), we found that the continuous analysis of 7-day SD of sleep duration was modestly associated with prevalent HTN. However, 7-day SD of sleep duration more than 90 min was independently associated with SBP [β: 1.55; 95% confidence interval (CI) 0.23–2.88] and DBP (β: 1.07; 95% CI 0.12–2.01). Stratification analysis excluding participants with OSA revealed that a 7-day SD of sleep duration greater than 90 min was associated with a 48% higher chance of having HTN (OR: 1.48; 95% CI: 1.05–2.07). No significant associations were observed for the SD of sleep-onset timing.

Conclusion:
Objective measurement of sleep irregularity, evaluated by SD of sleep duration for 1 week, was associated with HTN and higher BP levels, especially in participants without OSA.
Timing of Referrals to a Down Syndrome Parent Group by Race
Authors: Ansong Elsie O. , Jones Kari , Santoro Stephanie L. 
Published: February 2023

Introduction:
The Down Syndrome Association of Central Ohio (DSACO) is a nonprofit organization that supports families, promotes community involvement, and encourages lifetime opportunities for people with Down syndrome.

Methods:
At DSACO, ongoing efforts for quality improvement included: a Medical Advisory Committee in 2016, the creation of resources groups for Latino families in 2017, for Somali families from 2018 to 2019, and for African American families in fall 2018, presentations at birth hospitals, and close tracking of referrals from hospitals when an infant with Down syndrome is born. In addition, the timing of referrals, either “early” (on the day of birth or the first day after birth) or “late” (2 or more days after birth), were tracked and plotted in p charts.

Results:
From January 2017 to April 2021, DSACO received 167 referrals; of these, a median of 65% was received “early.” When analyzing all referrals to DSACO, no special cause was seen over the time studied. When evaluating the timing of referral to DSACO by race, referrals for 78% of White families were early (105/135 referrals). In comparison, referrals for 9% of minority families were early (3/32 referrals).

Conclusions:
The timing of DSACO referral differed by race. Outreach efforts did not change referral timing but led to a more diverse DSACO membership. Future study is needed to confirm if there is racial disparity in the timing of referrals to resources nationally and to understand the barriers in referring diverse families to Down syndrome nonprofit organizations.