bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of neoadjuvant stereotactic body radiotherapy plus adebrelimab and chemotherapy for triple-negative breast cancer: A pilot study
Authors: Chen Guanglei , Gu Xi , Zhang Xu , Yu Xiaopeng , Zhang Yu , Xue Jinqi , Li Ailin , Zhao Yi , He Guijin , Tang Meiyue , Xing Fei , Yin Jianqiao , Bian Xiaobo , Han Ye , Cao Shuo , Liu Chao , Jiang Xiaofan , Zhang Keliang , Xia Yan , Li Huajun , Niu Nan , Liu Caigang 
Published: August 2023

AbstractBackgroundEmerging data have supported the immunostimulatory role of radiotherapy, which could exert a synergistic effect with immune checkpoint inhibitors (ICIs). With proven effective but suboptimal efficacy of ICI and chemotherapy in triple-negative breast cancer (TNBC), we designed a pilot study to explore the efficacy and safety of neoadjuvant stereotactic body radiotherapy (SBRT) plus adebrelimab and chemotherapy in TNBC patients.MethodsTreatment-naïve TNBC patients received two cycles of intravenous adebrelimab (20mg/kg, every 3 weeks), and SBRT (24Gy/3f, every other day) started at the second cycle, then followed by six cycles of adebrelimab plus nab-paclitaxel (125 mg/m2on days 1 and 8) and carboplatin (area under the curve 6 mg/mL per min on day 1) every 3 weeks. The surgery was performed within 3-5 weeks after the end of neoadjuvant therapy. Primary endpoint was pathological complete response (pCR, ypT0/is ypN0). Secondary endpoints included objective response rate (ORR), residual cancer burden (RCB) 0-I and safety.Results13 patients were enrolled and received at least one dose of therapy. 10 (76.9%) patients completed SBRT and were included in efficacy analysis. 90% (9/10) of patients achieved pCR, both RCB 0-I and ORR reached 100% with 3 patients achieved complete remission. Adverse events (AEs) all-grade and grade 3-4 occurred in 92.3% and 53.8%, respectively. 1 (7.7%) patient had treatment-related serious AEs. No radiation-related dermatitis or death occurred.ConclusionsAdding SBRT to adebrelimab and neoadjuvant chemotherapy led to a substantial proportion of pCR with acceptable toxicities, supporting further exploration of this combination in TNBC patients.FundingThis research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.Clinical trial numberNCT05132790.
Identification of Novel Genes Associated with Atrial Fibrillation and Development of Atrial Fibrillation Predictive Models by Incorporating Polygenic Risk Scores and PheWAS-Derived Risk Factors
Authors: Chen Shih-Yin , Chen Yu-Chia , Liu Ting-Yuan , Chang Kuan-Cheng , Chang Shih-Sheng , Wu Ning , Wu Donald Lee , Dunlap Rylee Kay , Chan Chia-Jung , Tsai Fuu-Jen 
Published: August 2023

AbstractBACKGROUND:Atrial fibrillation (AF) is the most common atrial arrhythmia and is subcategorized into numerous clinical phenotypes. Previous studies demonstrated that early-onset AF was associated with genetic loci among the certain populations.OBJECTIVES:The objective of this study was to develop AF predictive models using AF-associated single-nucleotide polymorphisms (SNPs) selected from the Genome-Wide Association Study (GWAS) of a large cohort of Taiwanese and explore whether the models posed the prediction power for AF.METHODS:75,121 total subjects including 5,694 AF patients and 69,427 normal controls with the GWAS data were included in this study. The polygenic risk scores based on AF-associated SNPs were determined and then integrated with Phenome-wide association study (PheWAS)-derived risk factors including clinical and demographic variables. The robust AF predictive models were developed through advanced statistical and machine learning techniques and then were evaluated in terms of discrimination, calibration, and clinical utility.RESULTS:The results demonstrated that the top 30 significant SNPs associated with AF were located on chromosomes 10 and 16, which involvedNEURL1,SH3PXD2A,INA,NT5C2,STN1, andZFHX3genes withINA,NT5C2, andSTN1being new discoveries in association with AF. The GWAS predictive power for AF had an area under the curve (AUC) of 0.626 (P< 0.001) and 0.851 (P< 0.001) before and after adjusting with age and gender, respectively. The results of PheWAS analysis showed that the top 10 diseases associated with discovered genes were all circulatory system diseases. The results of this study suggested that AF could be predicted by genetic information alone with moderate accuracy. The GWAS could be a robust and useful tool for detecting polygenic diseases by capturing the cumulative effects and genetic interactions of moderately associated but statistically significant SNPs.CONCLUSIONS:By integrating genetic and phenotypic data, the accuracy and clinical relevance of predictive models for AF were improved. The results of this study might improve AF risk classification, enable personalized interventions, and ultimately reduce the burden of AF-related morbidity and mortality.Abstract FigureGraphic Abstract
Real-time Quantification of in vivo cerebrospinal fluid velocity using fMRI inflow effect
Authors: Diorio Tyler C. , Nair Vidhya Vijayakrishnan , Patel Neal M. , Hedges Lauren E. , Rayz Vitaliy L. , Tong Yunjie 
Published: August 2023

AbstractIn vivoestimation of cerebrospinal fluid (CSF) velocity is crucial for understanding the glymphatic system and its potential role in neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. Current cardiac or respiratory gated approaches, such as 4D flow MRI, cannot capture CSF movement in real time due to limited temporal resolution and in addition deteriorate in accuracy at low fluid velocities. Other techniques like real-time PC-MRI or time-spatial labeling inversion pulse are not limited by temporal averaging but have limited availability even in research settings. This study aims to quantify the inflow effect of dynamic CSF motion on functional magnetic resonance imaging (fMRI) forin vivo, real-time measurement of CSF flow velocity. We considered linear and nonlinear models of velocity waveforms and empirically fit them to fMRI data from a controlled flow experiment. To assess the utility of this methodology in human data, CSF flow velocities were computed from fMRI data acquired in eight healthy volunteers. Breath holding regimens were used to amplify CSF flow oscillations. Our experimental flow study revealed that CSF velocity is nonlinearly related to inflow effect-mediated signal increase and well estimated using an extension of a previous nonlinear framework. Using this relationship, we recovered velocity fromin vivofMRI signal, demonstrating the potential of our approach for estimating CSF flow velocity in the human brain. This novel method could serve as an alternative approach to quantifying slow flow velocities in real time, such as CSF flow in the ventricular system, thereby providing valuable insights into the glymphatic system’s function and its implications for neurological disorders.
Social determinants of adult health outcomes in Sickle cell disease: a scoping review protocol
Authors: Blake Alphanso , Bennett Nadia , Ferguson Trevor , Harding Seeromanie , Asnani Monika 
Published: August 2023

AbstractObjectiveTo summarize the evidence and identify gaps in the literature related to the impact of social factors on health outcomes across the life course for persons with Sickle Cell Disease.IntroductionSickle cell disease (SCD) is a group of genetic diseases where abnormal hemoglobin is associated with recurrent complications across the life course which results in increased morbidity or death. The social determinants of health may impact health outcomes throughout the life course of these individuals. Better understanding of the effect that these factors and their complications have may influence management approaches both medically and socially to improve quality of life.Inclusion criteriaAll studies published in English between 1973 and 2023 of persons of all ages living with SCD (SS, SC, SB0SB+), examining factors related to the social determinants of health will be included. Conference abstracts, editorials and opinion papers will be excluded.MethodsMethods proposed by the Joanna Briggs Institute (JBI) and by Westphaln and colleagues in 2021 will be used. The electronic databases Academic Search Ultimate (EBSCO), Open Science Framework and PubMed will be searched using a pre-specified search strategy developed with stakeholder input. All citations will be reviewed by two independent reviewers with disagreements adjudicated by a third reviewer. The screening process will be reported in a Preferred Reporting Items for Systematic Reviews Extensions for Scoping reviews (PRISMA-ScR) flow diagram. The Rayyan software will be used to manage the review process.
Protocol for the AutoRayValid-RBfracture Study: Evaluating the efficacy of an AI fracture detection system
Authors: Ruitenbeek Huib , Egnell Liv , Ziegeler Katharina , Brejnebøl Mathias Willadsen , Nybing Janus Uhd , Lensskjold Anders , Lisouski Pavel Klastrup , Lundemann Michael , Hermann Kay Geert A. , Boesen Mikael , Oei Edwin H.G. , Visser Jacob J. 
Published: August 2023

AbstractBackgroundRapidly diagnosing fractures in appendicular skeletons is vital in the ED, where junior physicians often interpret initial radiographs. However, missed fractures remain a concern, prompting AI-assisted detection exploration. Yet, existing studies lack clinical context. We propose a multi-center retrospective study evaluating the AI aid RBfracture™ v.1, aiming to assess AI’s impact on diagnostic thinking by analyzing consecutive cases with clinical data, providing insights into fracture detection and clinical decision-making.ObjectivesTo provide new insights on the potential value of AI tools across borders and different healthcare systems. We will evaluate the performance of the AI aid to detect fractures on conventional x-ray images and how its use could affect handling of these cases in a healthcare setting. In order to explore if the use of a trained and certified AI tool on clinical data exposes new challenges, a daily practice clinical scenario will be approached by minimising selection criteria and using consecutive cases. A multicenter, retrospective, diagnostic accuracy cross-sectional design incorporates clinical context.MethodsThe multicenter study spans three European sites without onsite hardware. AI system RBfracture™ v.1 maintains consistent sensitivity and specificity thresholds. Eligibility involves age ≥21 with x-ray indications for appendicular fractures. Exclusions include casts, follow-up x-rays, nearby hardware. AI aids retrospective fracture detection. Reader sessions include radiology and emergency care residents and trainees reading with and without AI. Fractures are marked, rated, with expert-established reference standards.DataSequential patient studies at three sites yield 500 cases per site. Data includes anatomy, referral notes, radiology reports, and radiographic images. Expert readers use annotations, clinical context for standards. Statistical methods include dichotomized confidence ratings, sensitivity, specificity calculations, site-based analysis and subgroup considerations.Reference StandardTwo experienced readers annotate fractures; if their annotations overlap by 25% or more, the common area is the reference. Discrepancies are resolved by a local expert. Individual fractures are labelled.
Hemoglobin specific volume width promotes the prevalence and poor long-term prognosis of American adult hypertensive patients: the NHANES 1999-2020
Authors: Zhang Lin , Chang Jun , Wang Kaiyue , Zhou Ying , Wang Liming , Zhang Lele , Zhang Xuemei , Fu Zhifei , Han Lifeng , Gao Xiumei 
Published: August 2023

BackgroundHypertensive patients are always accompanied by erythrocyte dysfunction. However, current erythrocyte-related indicators can’t explain hypertension’s prevalence and long-term prognosis. Therefore, hemoglobin specific volume width (HSW) was first created to explain this phenomenon.Methods59,867 adult participants from National Health and Nutrition Examination Survey (NMAHES) were included. HSW’s quartiles were determined with Q1 [1.88,3.64] cL/g, Q2 (3.64,3.84] cL/g, Q3 (3.84,4.11] cL/g, and Q4 (4.11,11.74] cL/g. 21,006 hypertensive patients had a whole following time 97 (51, 151) months, 15,519 hypertensive patients were alive, and 5,487 were dead. The relationship between HSW and hypertension was analyzed.ResultsAmong Controlsn=35,677 and Hypertensive patientsn=24,190, the percentages of hypertension in quartiles of HSW (Q1, Q2, Q3, and Q4) were 28.59%, 33.35%, 39.37%, and 47.74%. Adjusted odds ratio (OR) in HSW was still significant, 1.23 (95% CI 1.11,1.36). Among dead (n=5,487) and alive hypertensive patients (n=15,519), the percentages of hypertensive mortality in quartiles of HSW were 17.66%, 20.46%, 20.78%, and 25.02%. The adjusted HSW hazard ratio (HR) was 1.91(95%CI 1.69,2.16). Processing Q1 as reference, the HR for Q4 was 2.35 (95% CI 2.06, 2.69). Males had a higher risk (HR: 1.53 95% CI 1.24,1.89) of poor prognosis than females (HR: 1.48 95% CI 1.17,1.87). Individuals <=60 years old (HR: 2.25 95% CI 1.78,2.85) had a higher risk of poor prognosis than those >60. Hypertensive patients with HSW > 3.89 cL/g had a poor prognosis than HSW <= 3.89 cL/g.ConclusionsHSW is an innovative independent risk factor for hypertensive prevalence and long-term prognosis.
Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP
Authors: Nadel Cory M. , Wucherer Kristin , Oehler Abby , Thwin Aye C. , Basu Koli , Callahan Matthew D. , Southworth Daniel R. , Mordes Daniel A. , Craik Charles S. , Gestwicki Jason E. 
Published: August 2023

ABSTRACTMicrotubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, tau is aberrantly modified by post-translational modifications (PTMs), including hyper-phosphorylation. However, it is often unclear which of these PTMs contribute to tau’s accumulation or what mechanisms might be involved. To explore these questions, we focused on a cleaved proteoform of tau (tauC3), which selectively accumulates in AD and was recently shown to be degraded by its direct binding to the E3 ubiquitin ligase, CHIP. Here, we find that phosphorylation of tauC3 at a single residue, pS416, is sufficient to block its interaction with CHIP. A co-crystal structure of CHIP bound to the C-terminus of tauC3 revealed the mechanism of this clash and allowed design of a mutation (CHIPD134A) that partially restores binding and turnover of pS416 tauC3. We find that pS416 is produced by the known AD-associated kinase, MARK2/Par-1b, providing a potential link to disease. In further support of this idea, an antibody against pS416 co-localizes with tauC3 in degenerative neurons within the hippocampus of AD patients. Together, these studies suggest a discrete molecular mechanism for how phosphorylation at a specific site contributes to accumulation of an important tau proteoform.
The use of vision system to determine lateral deviation from landing trajectory
Authors: Rogalski Tomasz , Rzucidło Paweł , Noga Stanisław , Nowak Dariusz 
Published: August 2023

Purpose
This study presents an image processing algorithm capable of calculating selected flight parameters requested by flight control systems to guide aircraft along the horizontal projection of the landing trajectory. The parameters identified based on the basics of the image of the Calvert light system appearing in the on-board video system are used by flight control algorithms that imitate the pilot’s schematics of control. Controls were generated using a fuzzy logic expert system. This study aims to analyse an alternative to classical solutions that can be applied to some specific cases.

Design/methodology/approach
The paper uses theoretical discussions and breakdowns to create the basics for the development of structures for both image processing algorithms and control algorithms. An analytical discussion on the first stage was transformed into laboratory rig tests using a real autopilot unit. The results of this research were verified in a series of software-in-the-loop computer simulations.

Findings
The image processing method extracts the most crucial parameters defining the relative position of the aircraft to the runway, as well as the control algorithm that uses it.

Practical implications
In flight control systems that do not use any dedicated ground or satellite infrastructure to land the aircraft.

Originality/value
This paper presents the original approach of the author to aircraft control in cases where visual signals are used to determine the flight trajectory of the aircraft.
Applying blockchain to quality food products: a marketing perspective
Authors: Bonetti Enrico , Bartoli Chiara , Mattiacci Alberto 
Published: August 2023

PurposeThe purpose of this paper is to enrich the knowledge about blockchain (BC) technology implementation in the agri-food industry by providing an interpretive framework of the key marketing opportunities and challenges, related to the adoption of BC for Geographical Indication (GI) products.Design/methodology/approachThe study adopts an explorative qualitative research design through the cognitive mapping technique applied to the cognition of different market players involved in agri-food BC projects: farmers, distributors, companies and consultancies.FindingsThis study presents a comprehensive examination of the marketing impacts of BC across various marketing objectives, including product enhancement, brand positioning, consumer relationships, market access and supply chain relationships. It highlights the capability of BC to facilitate data-enabled ecosystems within the agri-food sector, involving supply chain actors and control agencies. Additionally, the study sheds light on the challenges (technological, collaborative, political, financial and organizational) associated with the implementation of BC in the marketing of agri-food products.Research limitations/implicationsThis work provides a comprehensive examination of the relevance of BC in the marketing activities of firms, particularly in the context of quality food products. It highlights the main areas of impact and effects and emphasizes the complexity of the phenomenon, which extends beyond its technical issues. Furthermore, it offers a systematic exploration of the challenges associated with the adoption of BC in marketing activities, thus contributing to a broader understanding of the implications of BC adoption in companies' marketing strategies.Practical implicationsThe practical implications for this work addresses both GI companies and policy makers. Implications for companies relate to the market benefits associated with the implementation of BC, which allow further strengthening of market positioning, relationships of trust within the supply chain and integration between physical and digital market channels. The study also systematizes the challenges underlying the implementation of BC projects. The implications for policy makers regard the role they have to play in BC projects at regulatory, financial and policy levels.Originality/valueStudies focusing on BC applications in marketing are still limited and characterized by a very narrow perspective (especially in the food industry). This study contributes to the conceptual design of the marketing applications of BC in the agri-food sector. The value of the study also lies in having framed the marketing impacts of BC in a holistic perspective, along with the technological and non-technological challenges that are related to the integration of BC in marketing strategy and operations.
A novel consensus reaching method for the preference-approval structure based on regret theory and its application in evaluating pension institutions
Authors: Shi Qinggang , Li Peng , Xu Zhiwei 
Published: August 2023

PurposeThe purpose of this paper is to propose a consensus method for multi-attribute group decision-making (MAGDM) problems based on preference-approval structure and regret theory, which can improve the efficiency of decision-making and promote the consensus level among individuals.Design/methodology/approachFirst, a new method to obtain the reference points based on regret theory and expert weighting method is proposed. Second, a consensus reaching method based on preference-approval structure is proposed. Then, an adjustment mechanism to further improve the consensus level between individuals is designed. Finally, an example of the assessment of elderly care institutions is used to illustrate the feasibility and effectiveness of the proposed method.FindingsThe feasibility and validity of the proposed method are verified by comparing with the advanced two-stage minimum adjustment method. The compared results show that the proposed method is more consistent with the actual situation.Research limitations/implicationsThis paper presents a consensus reaching method for MAGDM based on preference-approval structure, which considers the avoidance behaviors of individuals and reference points. Decision makers (DMs) can use this approach to rank and categorize alternatives while further increasing the level of consensus among them. This can further help determine the optimal alternative more efficiently.Originality/valueA new MAGDM problem based on the combination of regret theory and individual reference points is proposed. Besides, a new method of obtaining experts' weights and a consensus reaching method for MAGDM based on preference-approval structure are designed.
The effect of board characteristics on tax aggressiveness: the case of listed entities in Sri Lanka
Authors: Shamil Mohamed Mihilar , Gooneratne Dulni Wanya , Gunathilaka Dasitha , Shaikh Junaid M. 
Published: August 2023

PurposeThis study examines the effect of board characteristics on the tax aggressiveness of listed companies on the Colombo Stock Exchange in Sri Lanka.Design/methodology/approachThe sample consists of 264 firm-year observations of non-financial listed companies in Sri Lanka from 2014 to 2019. The dynamic panel system GMM technique was used to test the hypotheses, and further analyses were performed using the propensity score matching technique.FindingsAll four effective tax rate measures' mean values were lower than the statutory tax rate, indicating the likelihood of tax planning. Whether board attributes are likely to mitigate tax aggressiveness is uncertain because the results are inconsistent and depend on the ETR measure. Similarly, the logistic regression results derived using the PSM approach are inconsistent, suggesting that board characteristics may have a limited effect on tax aggressiveness. Hence, the corporate governance-tax aggressiveness nexus is limited in the case of Sri Lanka.Research limitations/implicationsThis investigation is limited to non-financial listed companies in Sri Lanka and incorporates only four tax aggressiveness measures. Findings are imperative for policymakers, regulators, and professional bodies to improve corporate governance codes and rules to enhance organisational transparency toward corporate tax payments.Social implicationsAggressive tax planning by companies will reduce government tax revenue, hinder social progress, and cause public mistrust of large corporations and institutions.Originality/valueThis study provides insight into the nexus between corporate governance and tax aggressiveness in a middle-income economy in South Asia hit by an economic crisis where tax revenue has fallen and tax enforcement is weak.