Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2)
Authors: Griessbach Alexandra , Chammartin Frédérique , Abela Irene A , Amico Patrizia , Stoeckle Marcel P , Eichenberger Anna L , Hasse Barbara , Braun Dominique L , Schuurmans Macé M , Müller Thomas F , Tamm Michael , Audigé Annette , Mueller Nicolas J , Rauch Andri , Günthard Huldrych F , Koller Michael T , Trkola Alexandra , Epp Selina , Amstutz Alain , Schönenberger Christof M , Taji Heravi Ala , Kusejko Katharina , Bucher Heiner C , Briel Matthias , Speich Benjamin ,   Swiss HIV Cohort Study and the Swiss Transplant Cohort Study, Abela Irene , Aebi-Popp Karoline , Anagnostopoulos Alexia , Battegay Manuel , Bernasconi Enos , Braun Dominique Laurent , Bucher Heiner , Calmy Alexandra , Cavassini Matthias , Ciuffi Angela , Dollenmaier Günter , Egger Matthias , Elzi Luigia , Fehr Jan , Fellay Jacques , Furrer Hansjakob , Fux Christoph , Günthard Huldrych , Hachfeld Anna , Haerry David , Hasse Barbara , Hirsch Hans , Hoffmann Matthias , Hösli Irene , Huber Michael , Jackson-Perry David , Kahlert Christian , Kaiser Laurent , Keiser Olivia , Klimkait Thomas , Kouyos Roger Dimitri , Kovari Helen , Kusejko Katharina , Labhardt Niklaus , Leuzinger Karoline , Tejada Begona Martinez de , Marzolini Catia , Metzner Karin J , Müller Nicolas , Nemeth Johannes , Nicca Dunja , Notter Julia , Paioni Paolo , Pantaleo Giuseppe , Perreau Matthieu , Rauch Andri , Salazar-Vizcaya Luisa , Schmid Patrick , Speck Roberto , Stöckle Marcel , Tarr Philip , Trkola Alexandra , Wandeler Gilles , Weisser Maja , Yerly Sabine , Amico Patrizia , Aubert John-David , Banz Vanessa , Beckmann Sonja , Beldi Guido , Berger Christoph , Berishvili Ekaterine , Berzigotti Annalisa , Binet Isabelle , Bochud Pierre-Yves , Branca Sanda , Bucher Heiner , Catana Emmanuelle , Cairoli Anne , Chalandon Yves , De Geest Sabina , De Rougemont Olivier , De Seigneux Sophie , Dickenmann Michael , Dreifuss Joëlle Lynn , Duchosal Michel , Fehr Thomas , Ferrari-Lacraz Sylvie , Garzoni Christian , Golshayan Déla , Goossens Nicolas , Haidar Fadi , Halter Jörg , Heim Dominik , Hess Christoph , Hillinger Sven , Hirsch Hans H. , Hirt Patricia , Hoessly Linard , Hofbauer Günther , Huynh-Do Uyen , Immer Franz , Koller Michael , Laesser Bettina , Lamoth Frédéric , Lehmann Roger , Leichtle Alexander , Manuel Oriol , Marti Hans-Peter , Martinelli Michele , McLin Valérie , Mellac Katell , Merçay Aurélia , Mettler Karin , Mueller Nicolas J. , Müller-Arndt Ulrike , Müllhaupt Beat , Nägeli Mirjam , Oldani Graziano , Pascual Manuel , Passweg Jakob , Pazeller Rosemarie , Posfay-Barbe Klara , Rick Juliane , Rosselet Anne , Rossi Simona , Rothlin Silvia , Ruschitzka Frank , Schachtner Thomas , Schaub Stefan , Scherrer Alexandra , Schnyder Aurelia , Schuurmans Macé , Schwab Simon , Sengstag Thierry , Simonetta Federico , Stampf Susanne , Steiger Jürg , Stirnimann Guido , Stürzinger Ueli , Van Delden Christian , Venetz Jean-Pierre , Villard Jean , Vionnet Julien , Wick Madeleine , Wilhelm Markus , Yerly Patrick 
Published: March 2023

AbstractExtension of the COVERALL (COrona VaccinE tRiAL pLatform) randomized trial showed noninferiority in antibody response of the third dose of Moderna mRNA-1273 vaccine (95.3% [95% confidence interval {CI}, 91.9%–98.7%]) compared to Pfizer-BioNTech BNT162b2 vaccine (98.1% [95% CI, 95.9%–100.0%]) in individuals with different levels of immunosuppression (difference, −2.8% [95% CI, −6.8% to 1.3%]).