bluuebunny/crossref_metadata_2025_split huggingface dataset:
Free sea or territorial waters? The Sino-Japanese Xiongyue fishing dispute, 1906–1912
Authors: Shen Jiaying 
Published: February 2023

AbstractFollowing victory in the Russo-Japanese War, the Meiji government sought to expand its maritime influence in Northeast Asia by developing pelagic fisheries in the newly acquired Kwantung leased territory, but it encountered immediate resistance from the Qing court, which had just embarked upon ambitious reform to strengthen maritime defence through the building of a national fishing industry. The dispute first emerged as a clash between Japanese and Chinese fishery protection companies on the seas adjacent to the Chinese city of Xiongyue. It then gave rise to a protracted Sino-Japanese legal debate on the question of whether the Xiongyue fishing ground was in the free sea or part of Chinese territorial waters. However, the 1912 settlement agreement made no mention of the legal status of the fishing ground. By examining this oft-neglected dispute, this article not only provides a rare East Asian case that illustrates the tension between the requirements of national sea borders and the principle of navigational freedom, but also explores how the Meiji and Qing governments perceived and practised international maritime law at the turn of the twentieth century. It argues that neither government viewed international maritime law as the only referential framework to solve the dispute, especially when it contributed little to the conflict settlement and contradicted their perceptions of the historical relations between East Asian countries.
Early detection of local SARS-CoV-2 outbreaks by wastewater surveillance: a feasibility study
Authors: Nauta Maarten , McManus Oliver , Træholt Franck Kristina , Lindberg Marving Ellinor , Dam Rasmussen Lasse , Raith Richter Stine , Ethelberg Steen 
Published: February 2023

Abstract
Wastewater surveillance and quantitative analysis of SARS-CoV-2 RNA are increasingly used to monitor the spread of COVID-19 in the community. We studied the feasibility of applying the surveillance data for early detection of local outbreaks. A Monte Carlo simulation model was constructed, applying data on reported variation in RNA gene copy concentration in faeces and faecal masses shed. It showed that, even with a constant number of SARS-CoV-2 RNA shedders, the variation in concentrations found in wastewater samples will be large, and that it will be challenging to translate viral concentrations into incidence estimates, especially when the number of shedders is low. Potential signals for early detection of hypothetical outbreaks were analysed for their performance in terms of sensitivity and specificity of the signals. The results suggest that a sudden increase in incidence is not easily identified on the basis of wastewater surveillance data, especially in small sampling areas and in low-incidence situations. However, with a high number of shedders and when combining data from multiple consecutive tests, the performance of wastewater sampling is expected to improve considerably. The developed modelling approach can increase our understanding of the results from wastewater surveillance of SARS-CoV-2.
Awards of the khudadad sarkar: medals from Tipu Sultan's Mysore
Authors: Rashid Adnan , Olikara Nidhin 
Published: February 2023

AbstractThe collection of the Asiatic Society, Calcutta, preserves a manuscript titled Risala-i-Padakah which was formerly in the library of the ruler of Mysore, Tipu Sultan (d. 1799). This manuscript has descriptions of medals with drawings illustrating their forms. We investigate the design of these medals and assert that Tipu Sultan understood the importance of rewarding his loyal subordinates with medals, thus transferring his authority down to them. The ‘People's Medals’ given to non-combatants, a novel award for those times, are also covered here in detail. We show that some of these medals, reflecting Deccan jewellery traditions, were actually awarded by Tipu Sultan himself to his men, who wore them; and we draw attention to the plunder of these medals, along with other treasures, during the sack of Seringapatam. The authors also view this as a demonstration of Tipu Sultan's regard for loyalty, rank, as well as good governance in opposition to estimates of him by contemporary British biographers. This article is the first documentation of these medals, which were the earliest to be awarded by any state in pre-modern India.
A note on variable markup, knowledge spillover, and multiple steady states in the variety expansion model
Authors: Morita Tadashi 
Published: February 2023

AbstractThis paper incorporates the variable elasticity of substitution preferences in the variety expansion model developed by Grossman and Helpman [(1991) Innovation and Growth in the Global Economy, MIT Press]. There exists a balanced growth path when the elasticity of substitution is constant with knowledge spillover. When the elasticity of substitution is variable and the knowledge spillover is sufficiently small, a unique and stable steady state exists. When the knowledge spillover is sufficiently large, the steady state is unique and unstable. When the size of the knowledge externality is moderate, multiple equilibria exist.
The end of Late Glacial in north-eastern Iberia: the small mammal assemblage from Cudó cave (Mont-Ral, Tarragona)
Authors: ARJANTO Dama Q. , FERNÁNDEZ-GARCÍA Mónica , LÓPEZ-GARCÍA Juan Manuel , VERGÈS Josep Maria 
Published: February 2023

ABSTRACTOne of the markers of the Late Pleistocene is highly fluctuating climatic conditions, with the Last Glacial Maximum (LGM, 26.5–19 ka cal before present (BP)) known to be one of the coldest periods. This work explores how the environment of north-eastern Iberia changed in relation to global climatic changes experienced during the Late Pleistocene, specifically around the LGM. Small mammal assemblages from Cudó cave (Tarragona, Spain) were used considering their well-known reliability for palaeoenvironmental reconstructions. Based on the taxonomic identification and the taphonomic analysis, several methodologies covering both qualitative and quantitative approaches were used to obtain the palaeoenvironmental information corresponding to level 107 and level 105 of Cudó cave (31.2–24.4 and 15.5–10.2 ka cal BP, respectively). The taphonomic results obtained point out owls (category 3) as the main accumulator of the small mammals. The palaeoenvironmental reconstruction shows that both levels experienced colder (−7.2oC/–4.4 °C) and wetter (+848 mm/ + 586 mm) climatic conditions than nowadays. However, in level 107 the environment was dominated by mid-European species and rocky landscape, while in level 105 it was dominated by Mediterranean species and woodland habitat. These conditions are consistent with the trend in north-eastern Iberia following several climatic events before and after the LGM coinciding with the period of Cudó cave assemblages.
Utilizing germinability thresholds for optimizing stale seedbed applications to control red rice (Oryza spp.) in California rice cropping systems
Authors: Galvin Liberty B. , Delong Maya T. , Al-Khatib Kassim 
Published: February 2023

Abstract“Weedy” red rice is a problematic weed with phenotypic similarities to cultivated rice. Limited herbicide availability has driven a need for nonchemical control options for managing this pest. One preplanting strategy that is being explored is the stale seedbed methodology, which aims to maximize soil seedbank withdrawals via germination. This technique is adapted in rice by flooding a field, waiting for germination and emergence of weed seedlings, and completing the method with a mechanical or chemical control application. Optimization of this process is dependent on maximizing weed seed germination, which is primarily influenced by both temperature and moisture availability. Germinability across a range of these factors is not well understood in California red rice. Thus, this study aimed to determine germinability of California red rice accessions under various temperature and water potential treatments. Previously described red rice accessions 1, 2, 3, and 5, along with ‘M206’, a common California rice cultivar, were exposed to temperatures from 10 to 40 C in 5 C increments in combination with water potentials of 0, −0.2, −0.4, or −0.8 MPa until either germination or weed seed decay occurred. Statistical analysis indicated a three-way interaction between accession, temperature, and water potential. Germination reached 95% or greater when seeds were exposed to temperatures from 20 to 35 C in combination with 0 or −0.2 MPa. Germination was lowest when seeds were water stressed (−0.8 MPa) and when temperatures were colder than 20 C or warmer than 35 C. The ‘M206’ cultivar was utilized for comparison and demonstrated cold tolerance by germinating at 10 C, whereas weedy accessions 1, 2, and 3 did not. When temperatures were at or above 15 C, however, ‘M206’ germinated less often compared with all weedy accessions. Historical preplant temperatures in this region align with those required for weedy rice germination. Thus, the stale seedbed methodology is a viable strategy in years when ample floodwater is available.
Evaluating Northern Hemisphere Growing Season Net Carbon Flux in Climate Models Using Aircraft Observations
Authors: Loechli Morgan , Stephens Britton B. , Commane Roisin , Chevallier Frédéric , McKain Kathryn , Keeling Ralph F. , Morgan Eric J. , Patra Prabir K. , Sargent Maryann R. , Sweeney Colm , Keppel‐Aleks Gretchen 
Published: February 2023

AbstractUnderstanding terrestrial ecosystems and their response to anthropogenic climate change requires quantification of land‐atmosphere carbon exchange. However, top‐down and bottom‐up estimates of large‐scale land‐atmosphere fluxes, including the northern extratropical growing season net flux (GSNF), show significant discrepancies. We developed a data‐driven metric for the GSNF using atmospheric carbon dioxide concentration observations collected during the High‐Performance Instrumented Airborne Platform for Environmental Research Pole‐to‐Pole Observations and Atmospheric Tomography Mission flight campaigns. This aircraft‐derived metric is bias‐corrected using three independent atmospheric inversion systems. We estimate the northern extratropical GSNF to be 5.7 ± 0.3 Pg C and use it to evaluate net biosphere productivity from the Coupled Model Intercomparison Project phase 5 and 6 (CMIP5 and CMIP6) models. While the model‐to‐model spread in the GSNF has decreased in the CMIP6 models relative to that of the CMIP5 models, there is still disagreement on the magnitude and timing of seasonal carbon uptake with most models underestimating the GSNF and overestimating the length of the growing season relative to the observations. We also use an emergent constraint approach to estimate annual northern extratropical gross primary productivity to be 56 ± 17 Pg C, heterotrophic respiration to be 25 ± 13 Pg C, and net primary productivity to be 28 ± 12 Pg C. The flux inferred from these aircraft observations provides an additional constraint on large‐scale gross fluxes in prognostic Earth system models that may ultimately improve our ability to accurately predict carbon‐climate feedbacks.
Mean Energy Flux, Associated Derived Height‐Integrated Conductances, and Field‐Aligned Current Magnitudes Evolve Differently During a Substorm
Authors: Carter J. A. , Milan S. E. , Forsyth C. , Lester M. E. , Walach M.‐T. , Gjerloev J. , Paxton L. J. , Anderson B. J. 
Published: February 2023

AbstractWe examine the average evolution of precipitation‐induced height‐integrated conductances, along with field‐aligned currents (FACs), in the nightside sector of the polar cap over the course of a substorm. Conductances are estimated from the average energy flux and mean energies derived from auroral emission data. Data are binned using a superposed epoch analysis on a normalized time grid based on the time between onset and recovery phase (δt) of each contributing substorm. We also examine conductances using a fixed time binning of width 0.25 hr. We split the data set by magnetic latitude of onset. We find that the highest conductances are observed for substorms with onsets that occur between 63 and 65° magnetic latitude, peaking at around 11 mho (Hall) and 4.8 mho (Pedersen). Substorms with onsets at higher magnetic latitudes show lower conductances and less variability. Changes in conductance over the course of a substorm appear primarily driven by changes (about 40% at onset) in the average energy flux, rather than the average energy of the precipitation. Average energies increase after onset slower than energy flux, later these energies decrease slowly for the lowest latitude onsets. No clear expansion of the main region 1 and region 2 FACs is observed. However, we do see an ordering of the current magnitudes with magnetic latitude of onset, particularly for region 1 downwards FAC in the morning sector. Peak current magnitudes occur slightly after or before the start of the recovery phase for the normalized and fixed‐time grids.
Observation of Scintillation Enhancements and Large‐Scale Structures Within the Equatorial Ionization Anomaly During a Sudden Stratospheric Warming Event
Authors: Valladares C. E. , Chen Y.‐J. , Hairston M. , Chau J. L. , Dhanya R. 
Published: February 2023

AbstractTotal electron content (TEC) and L‐band scintillations measured by several networks of GPS and GNSS receivers that operate in South and Central America and the Caribbean region are used to observe the morphology of the equatorial ionization anomaly (EIA), examine the evolution of plasma bubbles, and investigate the enhancement of L‐band scintillations that occurred on February 12 and 13, 2016. A few weak and short magnetic storms developed these days, and a minor sudden stratospheric warming (SSW) event was initiated a few days before. During these unusual conditions, TEC maps reported a split of the otherwise continuous crests of the EIA and the formation of a large‐scale (thousands of kilometers) almost‐circular structure. The western part of the southern crest faded, and a north‐south aligned segment developed near the center of the South American continent, joining the north and south crests of the EIA, forming an anomaly that resembled a closed loop on the eastern side of the continent. Concurrently with the anomaly events, several GPS stations reported increases in the L‐band scintillation index from 0.4 to values greater than 1. We analyzed TEC values from receivers between ±6° from the magnetic equator to identify and follow TEC depletions associated with plasma bubbles when they reach different stations. Although the magnetic activity was moderate (Kp = 3°), we believe that the anomaly redistribution and the scintillation enhancements are not related to a prompt penetration electric field but to enhancing the semidiurnal lunar tide propitiated by the onset of the minor SSW event. We found that depending on the lunar tide phase cycle, the neutral wind's meridional component can augment sub‐km scale irregularities and enhance L‐band scintillations through the wind gradient instability when U·n < 0 or the action of wind gradients (U) within the bubbles. Our observations imply that the SSW event enables prominent changes in the thermosphere wind system at F‐region altitudes.
Entrainment Rates and Eddy Exchange Coefficients From Reanalysis Sea Surface Salinity Data
Authors: Paldor Nathan , Shamir Ofer , Yacoby Itamar 
Published: February 2023

AbstractSimple analytic models developed in this study are applied to long‐term averages of reanalysis surface salinity data to quantify two fundamental properties of ocean currents. The first model is based on the new Freshening Length schema and its application to the Irminger Current yields a ratio of about 5 between the turbulent entrainment rates of surrounding fresher surface waters west and east of Greenland. The second model is based on the steady solution of the advection‐diffusion equation subject to suitable boundary conditions. The application of this model to the spreading of fresh, snow‐melt, water from the delta of the Po river in the northwest Adriatic Sea into the rest of the Sea yields a ratio of 8 × 104 m between the eddy exchange coefficient and the speed of advection in the Sea.
Unifying colors by primes
Authors: Li Han-Lin , Fang Shu-Cherng , Lin Bertrand M. T. , Kuo Way 
Published: February 2023

AbstractRGB and CYMK are two major coloring schemes currently available for light colors and pigment colors, respectively. Both systems use letter-based color codes that require a large range of values to represent different colors. The problem is that these two systems are hard to use for manipulating any operations involving combinations of colors, and they lack the capacity for inter-changeability or unification. Based on prime number theory and Goldbach’s conjecture, this study presents a universal color system (C235) using a number-based structure to encode, compute and unify all colors on a color wheel. The proposed C235system offers a unified representation for the efficient encoding and effective manipulation of color. It can be applied to designing a high-rate LCD system and colorizing objects with multiple attributes and DNA codons, opening the door to manipulating colors and lights for even broader applications.
METTL3 regulates breast cancer-associated alternative splicing switches
Authors: Achour Cyrinne , Bhattarai Devi Prasad , Groza Paula , Román Ángel-Carlos , Aguilo Francesca 
Published: February 2023

AbstractAlternative splicing (AS) enables differential inclusion of exons from a given transcript, thereby contributing to the transcriptome and proteome diversity. Aberrant AS patterns play major roles in the development of different pathologies, including breast cancer.N6-methyladenosine (m6A), the most abundant internal modification of eukaryotic mRNA, influences tumor progression and metastasis of breast cancer, and it has been recently linked to AS regulation. Here, we identify a specific AS signature associated with breast tumorigenesis in vitro. We characterize for the first time the role of METTL3 in modulating breast cancer-associated AS programs, expanding the role of the m6A-methyltransferase in tumorigenesis. Specifically, we find that both m6A deposition in splice site boundaries and in splicing and transcription factor transcripts, such asMYC, direct AS switches of specific breast cancer-associated transcripts. Finally, we show that five of the AS events validated in vitro are associated with a poor overall survival rate for patients with breast cancer, suggesting the use of these AS events as a novel potential prognostic biomarker.
GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer
Authors: Long Yao , Guo Jiaxing , Chen Jielin , Sun Jingyue , Wang Haiyan , Peng Xin , Wang Zuli , Lai WeiWei , Liu Na , Shu Long , Chen Ling , Shi Ying , Xiao Desheng , Liu Shuang , Tao Yongguang 
Published: February 2023

AbstractIn the treatment of most malignancies, radiotherapy plays a significant role. However, the resistance of cancer cells to ionizing radiation (IR) is the main reason for the failure of radiotherapy, which causes tumor recurrence and metastasis. In this study, we confirmed that GPR162, an orphan receptor in the G-protein-coupled receptor family, acted as a novel radiotherapy sensitizer by interacting with the stimulator of interferon genes (STING), which targeted DNA damage responses, activated IRF3, accelerated the activation of type I interferon system, promoted the expression of chemokines including CXCL10 and CXCL4, and inhibited the occurrence and development of tumors. Interestingly, the activation of STING by overexpression of GPR162 was independent of the classical pathway of cGAS. STING inhibitors could resist the antitumor effect of overexpression of GPR162 in IR-induced mouse models. In addition, most solid tumors showed low expression of GPR162. And the higher expression of GPR162 indicated a better prognosis in patients with lung adenocarcinoma, liver cancer, breast cancer, etc. In summary, these results suggested that GPR162 may serve as a potential sensitizer of radiotherapy by promoting radiotherapy-induced STING-IFN production and increasing the expression of chemokines including CXCL10 and CXCL4 in DNA damage response, providing an alternative strategy for improving cancer radiotherapy.
Chromatin profile-based identification of a novel ER-positive breast cancer subgroup with reduced ER-responsive element accessibility
Authors: Kumegawa Kohei , Saeki Sumito , Takahashi Yoko , Yang Liying , Osako Tomo , Nakadai Tomoyoshi , Amino Sayuri , Maeda Tetsuyo , Takahata Chikako , Mori Seiichi , Noda Tetsuo , Ohno Shinji , Ueno Takayuki , Maruyama Reo 
Published: February 2023

Abstract
Background
Oestrogen receptor (ER) signalling-dependent cancer cell growth is one of the major features of ER-positive breast cancer (BC). Inhibition of ER function is a standard and effective treatment for ER-positive tumours; however, ~20% of patients with ER-positive BC experience early or late recurrence. In this study, we examined intertumour heterogeneity from an epigenetic perspective based on the hypothesis that the intrinsic difference in epigenetic states around ER signalling pathway underlies endocrine therapy resistance.

Methods
We performed transposase-accessible chromatin sequencing (ATAC-seq) analysis of 42 BC samples, including 35 ER-positive(+) human epidermal growth factor receptor 2 (HER2)-negative(−) and 7 triple-negative tumours. We also reanalysed ATAC-seq data of 45 ER + /HER2 − tumours in the Cancer Genome Atlas (TCGA) BC cohort to validate our observations.

Results
We conducted a comprehensive analysis of cis-regulatory elements (CREs) using ATAC-seq, identifying three subgroups based on chromatin accessibility profiles. We identified a subgroup of ER-positive BCs with a distinctive chromatin accessibility pattern including reduced accessibility to ER-responsive elements (EREs). The same subgroup was also observed in TCGA BC cohort. Despite the reduced accessibility to EREs, the expression of ER and potential ER target genes were not decreased in these tumours.

Conclusion
Our findings highlight the existence of a subset of ER-positive BCs with unchanged ER expression but reduced EREs accessibility that cannot be distinguished by conventional immunostaining for ER. Future studies should determine whether these tumours are associated with resistance to endocrine therapy.
PGD2 displays distinct effects in diffuse large B-cell lymphoma depending on different concentrations
Authors: Hu Shunfeng , Lu Tiange , Shang Juanjuan , Cai Yiqing , Ding Mengfei , Zhou Xiangxiang , Wang Xin 
Published: February 2023

AbstractProstaglandin D2 (PGD2), an arachidonic acid metabolite, has been implicated in allergic responses, parasitic infection and tumor development. The biological functions and molecular mechanisms of PGD2 in diffuse large B-cell lymphoma (DLBCL) are still undefined. In this study, we firstly found the high concentration of serum PGD2 and low expression of PGD2 receptor CRTH2 in DLBCL, which were associated with clinical features and prognosis of DLBCL patients. Interestingly, different concentration of PGD2 displayed divergent effects on DLBCL progression. Low-concentration PGD2 promoted cell growth through binding to CRTH2 while high-concentration PGD2 inhibited it via regulating cell proliferation, apoptosis, cell cycle, and invasion. Besides, high-concentration PGD2 could induce ROS-mediated DNA damage and enhance the cytotoxicity of adriamycin, bendamustine and venetoclax. Furthermore, HDAC inhibitors, vorinostat (SAHA) and panobinostat (LBH589) regulated CRTH2 expression and PGD2 production, and CRTH2 inhibitor AZD1981 and high-concentration PGD2 enhanced their anti-tumor effects in DLBCL. Altogether, our findings demonstrated PGD2 and CRTH2 as novel prognostic biomarkers and therapeutic targets in DLBCL, and highlighted the potency of high-concentration PGD2 as a promising therapeutic strategy for DLBCL patients.