bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Elastic and Anisotropic Wood‐Derived Composite Scaffold with Antibacterial and Angiogenic Activities for Bone Repair
Authors: Chen Jiaqing , He Xiangheng , Sun Tianyi , Liu Kun , Chen Chunhua , Wen Wei , Ding Shan , Liu Mingxian , Zhou Changren , Luo Binghong 
Published: April 2023

AbstractScaffold‐based tissue engineering is a promising strategy to address the rapidly growing demand for bone implants, but developing scaffolds with bone extracellular matrix‐like structures, suitable mechanical properties, and multiple biological activities remains a huge challenge. Here, it is aimed to develop a wood‐derived composite scaffold with an anisotropic porous structure, high elasticity, and good antibacterial, osteogenic, and angiogenic activities. First, natural wood is treated with an alkaline solution to obtain a wood‐derived scaffold with an oriented cellulose skeleton and high elasticity, which can not only simulate collagen fiber skeleton in bone tissue but also greatly improve the convenience of clinical implantation. Subsequently, chitosan quaternary ammonium salt (CQS) and dimethyloxalylglycine (DMOG) are further modified on the wood‐derived elastic scaffold through a polydopamine layer. Among them, CQS endows the scaffold with good antibacterial activity, while DMOG significantly improves the scaffold's osteogenic and angiogenic activities. Interestingly, the mechanical characteristics of the scaffolds and the modified DMOG can synergistically enhance the expression of yes‐associated protein/transcriptional co‐activator with PDZ binding motif signaling pathway, thereby effectively promoting osteogenic differentiation. Therefore, this wood‐derived composite scaffold is expected to have potential application in the treatment of bone defects.
Microfluidic‐Assisted Growth of Perovskite Single Crystals for Photodetectors
Authors: Viola Ilenia , Matteocci Fabio , De Marco Luisa , Lo Presti Leonardo , Rizzato Silvia , Sennato Simona , Zizzari Alessandra , Arima Valentina , De Santis Antonio , Rovelli Chiara , Morganti Silvio , Auf der Maur Matthias , Testa Marianna 
Published: April 2023

AbstractThe organometal halide perovskites (OMHP) are promising candidates for fast, sensitive, and large area photodetectors. In the last decade, several techniques have been developed with complementary advantages. Film devices are thin and can be scaled to large area, but have a large number of grain‐boundaries related defects. Single bulk crystals instead have higher purity, but are thicker and can not be easily produced on large areas. In this work, a microfluidics‐assisted technique to realize a controlled growth of OMHP single crystals, in the form of microwires, directly on a conductive patterned substrates, is presented. This technique enables the realization of vertical devices with a pixelated sensor layer. The resulting devices present gain, a responsivity up to 200 AW−1and a fast rise time down to 35 µs. This is the first demonstration of a OMHP vertical device realized on a patterned substrate using microfluidics‐assisted techniques.
Flexible and Stretchable Piezoresistive Sensor with Decoupled Pressure Sensing Capability
Authors: Kim Wooseok , Kim Doyoung , Kim Jihwan , Park Sang Uk , Lee Hee Kyu , Joo Janghoon , Lee Se Gi , Chae Jeong Woo , Kim Jeonghyun , Han Seungyong , Baac Hyoung Won , Won Sang Min 
Published: April 2023

AbstractPressure sensors made on a mechanically deformable substrates are widely available for health monitoring systems, tactile sensors, and human–machine interfaces. While their sensitivity typically exceeds that of the human skin, it is highly challenging to perceive multiple kinds of mechanical inputs, such as normal, stretching, bending, and/or twisting forces, in a decoupled manner. For example, the interpretation of the specific pressure‐related distortion requires differentiation of such pressure stimuli from the simultaneously measured mixed deformation. This report proposes a sensor with an engineered geometrical configuration that dramatically reduces its mechanical distortion made by non‐pressure related stimuli. Such decoupled‐sensing capability for normal force is characterized by a linear response of fractional resistance change at 2.07 kPa−1and negligible responses to other deformations such as stretching and bending. An in vitro sensor demonstration for the diagnosis of stress urinary incontinence presents one mode of practical application of the sensor. Facile fabrication allows an interconnected array and wireless network to capture the spatial distribution of normal force and to record the data with consumer devices, respectively.
Large Orthorhombic Polyhedral CsPbBr3 Nanocrystals for Ultrasensitive Photodetectors with Type‐I Structures
Authors: Wang Jiahui , Yang Fengyi , Ding Guanghao , Hong Xun , Yang Qing 
Published: April 2023

AbstractLead halide perovskite nanocrystals (LHPs) are emerging with enormous potential for high‐performance optoelectronics. Regrettably, most of the reported lead halide nanocrystal‐based photodetectors (LHP‐PDs) focus on six‐faceted hexahedron (cube/platelet) shapes and encounter issues of interface recombination of the photogenerated electron‐hole pairs and low carrier migration efficiency. Herein, a vertical heterojunction photodetector with type‐I band alignment based on high‐quality polyhedral orthorhombic CsPbBr3 nanocrystals (NCs) is designed and realized. The results show that utilizing these rhombic dodecahedron CsPbBr3 as photosensitive layers, the p‐Si/CsPbBr3 device presents high responsivity (R) and detectability (D*) values of 8.36 A W−1 and 9.33 × 1013 Jones, a powerful weak light detection capability with an ultralow noise equivalent power (NEP) of 2.14 × 10−15 W Hz−1/2, and a fast response time of 90/162 µs . Meanwhile, based on theoretical density functional theory (DFT) and energy band analysis, it is shown that the recombination of photogenerated electron‐hole pairs can be significantly suppressed, and the spectral response of the PDs is almost contributed by photogenerated carriers in CsPbBr3 . The work provides a new avenue for improving the performance of PDs based on large‐size orthorhombic polyhedral CsPbBr3 NCs by morphological structure modulation and optimized band alignment engineering.
Intrinsically Healable Fabrics
Authors: Hsu Hsun‐Hao , Lo Tse‐Yu , Tseng Yu‐Hsuan , Lee Lin‐Ruei , Chen Si‐Rou , Chang Kai‐Jie , Kao Tzu‐Hsun , Lin Zong‐Hong , Chou Ho‐Hsiu , Chen Jiun‐Tai 
Published: April 2023

AbstractWearable electronics with healability have been extensively researched recently. To provide wearing comfort, fabrics are often adopted as the base materials. Intrinsic healability, however, is challenging for fabrics because of the inability to retain the fibrous morphologies. Herein, an unprecedented strategy is presented for producing electrospun fabrics that are intrinsically healable by carefully balancing the crystalline structural support and healing ability. Fluorocarbon polymers with different crystallinities are mixed with ionic liquids to form ionogels, which are spun into fabrics using a unique wet electrospinning apparatus. Importantly, the introduction of the crystalline domains prevents the fusion of the electrospun fibers; even after 1 year, no significant morphological change is observed. The nonwoven fabrics are not only stretchable and waterproof but also intrinsically healable. The ion–dipole interactions between the polar copolymers and ionic liquids provide the reversible physical crosslinking essential to the healing capability. When damaged, the fabrics can be overlapped and healed after applying pressure. Moreover, the fabrics demonstrate healability underwater. Healable sensing devices, pressure, and tensile sensors are also designed by printing ion‐conductive gels as electrodes. Both devices show good stability before and after healing. This work demonstrates the first example of intrinsically healable electrospun fabrics, which are promising for fabric‐based wearable electronics and smart clothing.
Wide‐Wavelength Tunable Mid‐Infrared Lasing Based on Black Arsenic Phosphorus
Authors: Zhang Junrong , Xie Maobin , Zhang Yushuang , Wang Junyong , Zhao Xinchao , Chen Cheng , Zhang Quanlong , Xia Meng , Li Jie , Dong Zhuo , Zhang Yan , Ren Zeqian , Liu Tong , Pan Anlian , Wang Shaowei , Zhang Kai 
Published: April 2023

AbstractMid‐infrared (MIR) semiconductor laser sources are essential for applications in gas detection, infrared imaging, and high‐speed free space optical communications. At present, the dynamic wavelength tunability of MIR lasers based on lead salt, antimonide, and quantum cascade lasers is limited and their compact size as well as heterogeneous integration are still challenging. Two‐dimensional (2D) materials, used as optical gain materials, have the flexible tunability and compatible van der Waals integrations—providing many new possibilities for constructing MIR laser sources of large tunability and high integration. Here, wide‐wavelength tunable MIR vertical cavity surface emitting lasers (VCSELs) integrated on silicon substrates are realized based on 2D black arsenic phosphorus (b‐AsxP1−x). The emission wavelength of the optically pumped laser device is demonstrated to be tuned from 3.42 to 4.65 µm at room temperature, which could be controlled by adjusting the alloy composition and thickness of the gain media b‐AsxP1−x. The tunable MIR VCSEL device would pave the way for further exploration of 2D materials‐based IR lasers working as on‐chip light sources.
Industrially Scalable and Refreshable Photocatalytic Foam
Authors: Yang Yawei , Wang Riyao , Han Zhongji , Wang Rui , He Jiancheng , Zhang Chengyu , Que Wenxiu 
Published: April 2023

AbstractSemiconductor photocatalysis has been a promising candidate for micropollutant degradation in environmental remediation. In the past 50 years, TiO2 nanomaterials‐based photocatalytic devices have been practically applied to ex‐situ sewage treatment. This work promotes the practical photocatalytic application of TiO2 nanomaterials by successfully fabricating a scalable and refreshable photocatalytic foam. The fabrication is done by firmly immobilizing catalyst nanoparticles on ethylene‐vinyl acetate (EVA) foam. The immobilization replaces commonly used ZnO promoter by TiO2 catalyst nanoparticles in raw materials during industrial foaming production processes. The as‐fabricated photocatalytic foam exhibits excellent photocatalytic activity, stability, and refreshability in in‐situ micropollutant degradation.
DNAJC21‐related thrombocytopenia in a young adult female
Authors: Aslan Deniz , Akgun‐Dogan Ozlem , Ay Beril , Çamurdan Mahmut Orhun , Mancılar Hanifenur , Alanay Yasemin 
Published: April 2023

AbstractBone marrow failure type 3 (BMFS3) (MIM:617052) is a subtype of inherited bone marrow failure syndromes (IBMFS) caused by homozygous pathogenic variants in DNAJC21. It was first defined in 2016, and to date, 19 patients have been reported. Here we report the first adult patient; a 20‐year‐old female with a novel frameshift variant in DNAJC21 presents with thrombocytopenia, dysmorphic findings, and ovarian agenesis. Our patient expands the clinical spectrum to the milder end and suggests that DNAJC21‐related disorders can have relatively mild presentations. Investigation of DNAJC21 variants in both childhood and adult patients with persistent, non‐progressive thrombocytopenia will allow to broaden the gene‐related phenotypic and genotypic spectrum and elucidate the pathophysiology. Therefore, we encourage revisiting undiagnosed patients to offer whole exome sequencing (WES) in adulthood.
Characterization of key manufacturing uncertainties in next generation therapeutics and vaccines across scales
Authors: Sarkis Miriam , Shah Nilay , Papathanasiou Maria M. 
Published: April 2023

AbstractViral vectors are advanced therapy products used as genetic information carriers in vaccine and cell therapy development and manufacturing. Despite the first product receiving market authorization in 2012, viral vector manufacturing has still not reached the level of maturity of biologics and is still highly susceptible to process uncertainties, such as viral titers and chromatography yields. This was exacerbated by the COVID‐19 pandemic when viral vector manufacturers were challenged to respond to the global demand in a timely manner. A key reason for this was the lack of a systematic framework and approach to support capacity planning under uncertainty. To address this, we present a methodology for: (i) identification of process cost and volume bottlenecks, (ii) quantification of process uncertainties and their impact on target key performance indicators, and (iii) quantitative analysis of scale‐dependent uncertainties. We use global sensitivity analysis as the backbone to evaluate three industrially relevant vector platforms: adeno‐associated, lentiviral, and adenoviral vectors. For the first time, we quantify how operating parameters can affect process performance and, critically, the trade‐offs among them. Results indicate a strong, direct proportional correlation between volumetric scales and propagation of uncertainties, while we identify viral titer as the most critical scale‐up bottleneck across the three platforms. The framework can de‐risk investment decisions, primarily related to scale‐up and provides a basis for proactive decision‐making in manufacturing and distribution of advanced therapeutics.
Kombination von Styrol‐ und Dien‐Struktur zu einem zyklischen Dien: Anionische Polymerisation von 1‐Vinylcyclohexen (VCH)
Authors: Hahn Christoph , Rauschenbach Moritz , Frey Holger 
Published: April 2023

AbstractWir berichten über die erste anionische Polymerisation von 1‐Vinylcyclohexen (VCH). Diese Struktur kann als eine Kombination von Dien und Styrol betrachtet werden. Die Polymerisation dieses zyklischen, 1,2‐disubstituierten 1,3‐Diens verlief quantitativ in Cyclohexan bei 25 °C mit sec‐Butyllithium als Initiator. Die erhaltenen Polymere wiesen gut kontrollierte Molekulargewichte im Bereich von 5 bis 142 kg mol−1 auf, die durch das molare Verhältnis von Monomer und Initiator einstellbar waren, mit engen Molekulargewichtsverteilungen (Đ<1.07–1.20). Die kinetische in situ Untersuchung der Polymerisation mittels 1H NMR ergab eine schwach ausgeprägte Gradientenstruktur für die Copolymere von Styrol und VCH (rSty=2.55, rVCH=0.39). PVCH, das in Cyclohexan mit sec‐BuLi als Initiator erhalten wurde, zeigte sowohl 1,4‐ als auch 3,4‐Einbau von VCH (Verhältnis: 64 : 36). Es wurde weiterhin gezeigt, dass die Mikrostruktur des resultierenden PVCH durch Zugabe eines polaren Additivs (THF) verändert werden kann, was zu einem erhöhten Anteil der 3,4‐Mikrostruktur (bis zu 78 %) und einer erhöhten Glasübergangstemperatur von bis zu 89 °C führte. Somit polymerisiert das Monomer VCH carbanionisch lebend wie ein Dien, liefert dabei jedoch recht rigide Polymere mit hoher Glasübergangstemperatur, was interessante Möglichkeiten für die Kombination mit anderen Dienen zu hoch definierten Polymerarchitekturen und Materialien bietet.
Chalkogenbindungs‐induzierte Doppelhelix basierend auf der Selbstassemblierung eines kleinen planaren Bausteins
Authors: Mehrparvar Saber , Wölper Christoph , Haberhauer Gebhard 
Published: April 2023

AbstractHelikale Strukturen auf einer molekularen Ebene werden in der Regel aus nicht‐planaren Einheiten gebildet. Umso faszinierender ist es, Helices ausgehend von planaren Bausteinen durch Selbstorganisation zu generieren. Bislang ist dies jedoch nur selten gelungen, wobei stets Wasserstoff‐ und Halogenbindungen beteiligt waren. Hier zeigen wir, dass das Motiv der Carbonyl‐Tellur‐Wechselwirkung geeignet ist, selbst kleine planare Einheiten im Festkörper zu helikalen Strukturen zusammenzufügen. Wir haben je nach Substitutionsmuster zwei verschiedene Arten von Helices gefunden: sowohl Einzel‐ als auch Doppelhelices. Bei der Doppelhelix sind die Stränge durch zusätzliche Te⋅⋅⋅Te‐Chalkogenbindungen verbunden. Bei der Einzelhelix kommt es im Kristall zu einer spontanen Enantiomerentrennung. Dies zeigt das Potential der Carbonyl‐Tellur‐Chalkogenbindung komplexe dreidimensionale Muster zu erzeugen.
Self‐assembly Mechanism and Chiral Transfer in CuO Superstructures
Authors: Zhang Jun , Vallée Renaud A. L. , Kochovski Zdravko , Zhang Wei , Shen Chen , Bertram Florian , Pinna Nicola 
Published: April 2023

AbstractChiral inorganic superstructures have received considerable interest due to the chiral communication between inorganic compounds and chiral organic additives. However, the demanding fabrication and complex multilevel structure seriously hinder the understanding of chiral transfer and self‐assembly mechanisms. Herein, we use chiral CuO superstructures as a model system to study the formation process of hierarchical chiral structures. Based on a simple and mild synthesis route, the time‐resolved morphology and the in situ chirality evolution could be easily followed. The morphology evolution of the chiral superstructure involves hierarchical assembly, including primary nanoparticles, intermediate bundles, and superstructure at different growth stages. Successive redshifts and enhancements of the CD signal support chiral transfer from the surface penicillamine to the inorganic superstructure. Full‐field electro‐dynamical simulations reproduced the structural chirality and allowed us to predict its modulation. This work opens the door to a large family of chiral inorganic materials where chiral molecule‐guided self‐assembly can be specifically designed to follow a bottom‐up chiral transfer pathway.
BN‐Butafulvenes and Their Application in the Synthesis of Highly Substituted BN‐9,1‐Naphthalenes
Authors: Wang Junyi , Zhu Shuai , Ma Wangyang , Lin Zhenyang , Ye Qing 
Published: April 2023

AbstractBN‐butafulvenes, mono‐BN isosteres of butafulvene and highly strained isomers of azaborines and B‐amino boroles, have been synthesized via hydrolysis of the urana‐borabicyclic complexes obtained from the reactions of bis(alkynyl)boranes with an uranacyclopropene complex. Their 4‐dimethylaminopyridine (DMAP) adducts can further isomerize to 1,2,4,6‐multisubstituted BN‐9,1‐naphthalenes. Both NMR reaction monitoring and theoretical calculations point to a reaction mechanism involving dearomative insertion of DMAP followed by two consecutive 1,2‐hydrogen shifts. The photophysical studies of the highly substituted BN‐9,1‐naphthalenes reveal a notable redshift in both the UV/Vis absorption and emission spectra. The (TD)‐DFT calculations corroborate the experimental data, suggesting that the strong π‐donating amino substitution at the 1‐ and/or 6‐positions destabilizes the HOMO, and thus leading to a notable decrease of the HOMO–LUMO gap.
A Tandem‐Locked Fluorescent NETosis Reporter for the Prognosis Assessment of Cancer Immunotherapy
Authors: Cheng Penghui , He Shasha , Zhang Chi , Liu Jing , Pu Kanyi 
Published: April 2023

AbstractNETosis, the peculiar type of neutrophil death, plays important roles in pro‐tumorigenic functions and inhibits cancer immunotherapy. Non‐invasive real‐time imaging is thus imperative for prognosis of cancer immunotherapy yet remains challenging. Herein, we report a Tandem‐locked NETosis Reporter 1 (TNR1) that activates fluorescence signals only in the presence of both neutrophil elastase (NE) and cathepsin G (CTSG) for the specific imaging of NETosis. In the aspect of molecular design, the sequence of biomarker‐specific tandem peptide blocks can largely affect the detection specificity towards NETosis. In live cell imaging, the tandem‐locked design allows TNR1 to differentiate NETosis from neutrophil activation, while single‐locked reporters fail to do so. The near‐infrared signals from activated TNR1 in tumor from living mice were consistent with the intratumoral NETosis levels from histological results. Moreover, the near‐infrared signals from activated TNR1 negatively correlated with tumor inhibition effect after immunotherapy, thereby providing prognosis for cancer immunotherapy. Thus, our study not only demonstrates the first sensitive optical reporter for noninvasive monitoring of NETosis levels and evaluation of cancer immunotherapeutic efficacy in tumor‐bearing living mice, but also proposes a generic approach for tandem‐locked probe design.
Optimal detuning of multivariable proportional integral controller based on data‐driven approach for an activated sludge process
Authors: Anchan Sanjith S. , Kumar Tanneru Hemanth , Sankar Rao Chinta 
Published: April 2023

AbstractThe study deals with designing a multivariable centralized proportional‐integral (PI) controller for an activated sludge process (ASP) by adopting a new tuning technique. To overcome the tedious task of manual tuning by a classical method that was based on Ziegler–Nichols tuning, a novel approach is developed by formulating the optimization problem and considering it along with the theoretical results to calculate the controller parameters. The proposed method is then compared with the reported method to demonstrate the advantages of the proposed approach. A nonlinear ASP model is selected to evaluate the performance of the designed controller. The simulation carried through the proposed optimization technique exhibits a significant improvement in closed‐loop performance for tuning the centralized controller. It is observed that the proposed method minimizes the effort of tuning the controller significantly. The proposed controller achieves better load disturbance response and lower overshoot than the reported method. The proposed method could improve integral absolute error (IAE) and integral time absolute error (ITAE) performance indices, ranging between 18.69% to 53.80% and 16.42% to 52.97% for a step change in and , respectively, which are better compared to the reported method. The study also assesses the control system's robustness for their uncertainties with the time constant and time delay.
Anchoring HPW by amino‐modified MIL‐101(Cr) to improve the properties of SPEEK in proton exchange membranes
Authors: Zhang Xiaocan , Ma Huixiao , Pei Tong , Zhang Ruochen , Liu Yiran 
Published: April 2023

AbstractIncorporating phosphotungstic acid (HPW) in proton exchange membranes (PEMs) is an effective way to improve proton conductivity, but its leakage remains a problem. It can be solved by immobilizing acid in membranes to enhance the stability of PEMs. Herein, we proposed a novel sulfonated poly(ether ether ketone) (SPEEK) composite membrane (SPEEK/HPW@MIL) that was prepared by blending amino‐modified MIL‐101(Cr) to anchor HPW. In this work, HPW was anchored through hydrogen bond to minimize its leakage and enhance the overall compatibility. The incorporation of MIL‐101(Cr)‐NH2 also helped lower the swelling ratio and improve the dimensional stability. Compared with pristine SPEEK and SPEEK/MIL membrane, the proton conductivity of the SPEEK/HPW@MIL composite membrane increased by 26% and 14%, respectively. The superior performance recommended a promising conception for anchoring HPW in PEMs.