bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic bevacizumab for pediatric patients with aggressive recurrent respiratory papillomatosis: One single‐center experience of eight patients
Authors: Liu Zengjun , Xiao Yang , Xu Jing , Liu Mengyao , Han Mingyong , Hu Wenyu , Zhu Dongyuan 
Published: February 2023

AbstractRecurrent respiratory papillomatosis (RRP) is a human papilloma virus (HPV)‐driven benign neoplasm, affecting larynx, trachea, and even lung, leading to voice disorders, airway obstruction, and postobstructive pneumonia. Several case reports have documented the promising efficacy of intravenous bevacizumab in reducing the need for surgical intervention among RRP patients. Herein, we present our experience on systemic bevacizumab for pediatric patients with aggressive RRP.MethodsWe retrospectively analyzed clinical, laboratory, radiological, and bronchoscopy findings of pediatric patients with aggressive RRP treated with systemic bevacizumab from July 26, 2021 to March 1, 2022.ResultsEight consecutive patients were included. Median age at treatment initiation was 5.5 (range 2.5–8) years old. Twenty‐five percentage (2/8) of patients experienced tracheotomy. Pulmonary papilloma was present in 62.5% (5/8) patients. Patients received median 10 cycles of bevacizumab (range 5–12). Patients received initial dosing of 4–7.5 mg/kg every 2–10 weeks of bevacizumab and subsequently extended after achieving the maximum response. None of the patients required surgical intervention during a median 10 (range 8.2–15.4) months follow‐up after initiating bevacizumab treatment. Both patients with evaluable lung lesions showed objective response. Only Grade 1 abdominal pain and Grade 1 hyperuricemia were recorded.ConclusionSystemic bevacizumab seems to be a well‐tolerated and effective treatment option for pediatric patients with aggressive RRP.
Potential drivers and consequences of regional phosphate depletion in the western subtropical North Pacific
Authors: Yuan Zhongwei , Browning Thomas J. , Zhang Ruifeng , Wang Chengwang , Du Chuanjun , Wang Yanmin , Chen Ying , Liu Zhiyu , Liu Xin , Shi Dalin , Dai Minhan 
Published: February 2023

AbstractIn regions of the nitrogen limited low latitude ocean, phosphate can also be depleted to levels initiating stress responses in marine microbes. Here, we associate a broad region of phosphate depletion in the subtropical North Pacific with different levels of phosphorus stress. Nutrient and aerosol addition experiments demonstrated primary nitrogen limitation of the bulk phytoplankton community, with supply of aerosols relieving this limitation. At northern sites with depleted phosphate, alkaline phosphatase activities were enhanced, indicating elevated phosphorus stress. Analysis of satellite‐ and model‐derived aerosol loading showed that aerosol deposition was elevated in these regions. Surface rate measurements suggested that the regional enhancement in phosphate depletion was predominantly driven by elevated nitrogen fixation, likely stimulated by the coincident supply of aerosol iron. Such observations are important for predicting future biogeochemical responses in the subtropical North Pacific to changing aerosol supply.
Generation of High‐Peak‐Power Femtosecond Pulses in Mamyshev Oscillators: Recent Advances and Future Challenges
Authors: Li Ying‐Ying , Gao Bo , Ma Chun‐Yang , Wu Ge , Huo Jia‐Yu , Han Ying , Wageh S. , Al‐Hartomy Omar A. , Al‐Sehemi Abdullah G. , Liu Lie , Zhang Han 
Published: February 2023

AbstractMamyshev oscillators (MOs) have attracted significant attention given their potential in yielding ultrafast lasers with high peak power. Based on step‐like saturable absorbers and self‐similar evolution in the gain fiber, MO technology features an advanced system capable of generating ultrastable femtosecond pulses with ultrahigh peak power. In this review, the principle of MO is presented in terms of their transmission function and tolerance to nonlinear phase shift and recent progress is reported in the advanced output performance of MO, manifested through high peak power, few‐cycles, high repetition rate, and supercontinuum generation. MO with various operation wavelengths (1, 1.5, and 2 μm) are examined, and MO starting methods are fully discussed, followed by a detailed account of diverse potential applications in areas such as biomedical imaging and material processing. Based on current progress, the prospective challenges and future directions of MO are highlighted and discussed.
Designing All‐Photonic Molecular Analogs for Electrical Components: A Reprogrammable Luminescent Filter Based on Ln3+ Ions
Authors: Hernández‐Rodríguez Miguel A. , Zanella Sofia , Fu Lianshe , Neto Albano N. Carneiro , Carlos Luís D. , Brites Carlos D. S. 
Published: February 2023

AbstractThe increasing demand for computing power and downscaling is reaching the limits of the current lithographic methods, further precluding the shrinkage of the silicon chips using state‐of‐the‐art top‐down approaches. Moreover, the current chip shortage exposes the excessive world dependence on silicon, stressing the need for silicon‐free computing technologies, preferably operating at the molecular level. Here, a Eu3+/Tb3+ co‐doped organic‐inorganic di‐ureasil hybrid is used to demonstrate an illustrative example of an all‐photonic device based on the emission temporal dynamics of the Eu3+ and Tb3+ ions. An all‐photonic approach for temperature‐reprogrammable change from a low‐pass filter to a high‐pass filter is reported, showing a firm step toward the design and development of molecular analogs of conventional circuit electrical passive components.
Experimental Methods to Get Polydopamine Films: A Comparative Review on the Synthesis Methods, the Films’ Composition and Properties
Authors: Ball Vincent , Hirtzel Jordana , Leks Guillaume , Frisch Benoît , Talon Isabelle 
Published: February 2023

AbstractIn 2007, polydopamine (PDA) films were shown to be formed spontaneously on the surface of all known classes of materials by simply dipping those substrates in an aerated dopamine solution at pH = 8.5 in the presence of Tris(hydroxymethyl) amino methane buffer. This universal deposition method has raised a burst of interest in surface science, owing not only to the universality of this water based one pot deposition method but also to the ease of secondary modifications. Since then, PDA films and particles are shown to have applications in energy conversion, water remediation systems, and last but not least in bioscience. The deposition of PDA films from aerated dopamine solutions is however a slow and inefficient process at ambient temperature with most of the formed material being lost as a precipitate. This incited to explore the possibility to get PDA and related films based on other catecholamines, using other oxidants than dissolved oxygen and other deposition methods. Those alternatives to get PDA and related films are reviewed and compared in this paper. It will appear that many more investigations are required to get better insights in the relationships between the preparation method of PDA and the properties of the obtained coatings.
Solid‐State Crosslinkable, Shape‐Memory Polyesters Serving Tissue Engineering
Authors: Delaey Jasper , Parmentier Laurens , Pyl Lincy , Brancart Joost , Adriaensens Peter , Dobos Agnes , Dubruel Peter , Van Vlierberghe Sandra 
Published: February 2023

AbstractAcrylate‐endcapped urethane‐based precursors constituting a poly(D,L‐lactide)/poly(ε‐caprolactone) (PDLLA/PCL) random copolymer backbone are synthesized with linear and star‐shaped architectures and various molar masses. It is shown that the glass transition and thus the actuation temperature could be tuned by varying the monomer content (0–8 wt%ε‐caprolactone,Tg,crosslinked= 10—42 °C) in the polymers. The resulting polymers are analyzed for their physico‐chemical properties and viscoelastic behavior (G′max= 9.6–750 kPa). The obtained polymers are subsequently crosslinked and their shape‐memory properties are found to be excellent (Rr= 88–100%,Rf= 78–99.5%). Moreover, their potential toward processing via various additive manufacturing techniques (digital light processing, two‐photon polymerization and direct powder extrusion) is evidenced with retention of their shape‐memory effect. Additionally, all polymers are found to be biocompatible in direct contact in vitro cell assays using primary human foreskin fibroblasts (HFFs) through MTS assay (up to ≈100% metabolic activity relative to TCP) and live/dead staining (>70% viability).
Synthesis of High Molecular Weight Polymers by Organocatalyzed Living Radical Polymerization and Self‐Assembly Behavior
Authors: Hu Keling , Liu Shun , Zhao Zhuo , Zhang Yongjun 
Published: February 2023

AbstractA mild organocatalyzed living radical polymerization method is studied for high molecular weight polymers (HMWPs), yielding low‐dispersity linear and star polymers (Đ = Mw/Mn = 1.03–1.28) up to Mn = 3.9 × 105 and monomer conversion = 80%, where Mn and Mw are the number‐ and weight‐average molecular weights, respectively. Even at high degrees of polymerization (DPs > 2000), this technique still features excellent control over molecular weights and Đ values, indicating the living character. The macroinitiators prepared at DP = 2000 are subsequently used for block polymerizations at high DPs (>2000) with functional methacrylates, yielding linear A‐B diblock, linear B‐A‐B triblock, and 3‐arm star A‐B diblock copolymers, suggesting the excellent block efficiency of macroinitiators synthesized at a high DP value (=2000). This mild organocatalyzed living radical polymerization technique can enhance the livingness of propagation radicals and kinetic chain length at high monomer conversions for monomers with moderate propagation rate coefficients (kps), reduce the persistent radical effect as much as possible, and hence enable HMWPs without the presence of metal catalyst, exogenous initiator, or harsh equipment. The obtained amphiphilic block copolymers present unique microphase separation behavior, and hold great potential in advanced materials applications, for example, thermosensitive nanocarriers.
Renal‐hepatic‐pancreatic dysplasia type 2: Perinatal lethal condition or a multisystemic disorder with variable expressivity
Authors: Gunther Kathryn , Imseis Essam M. , Samuel Joyce P. , Hillman Elizabeth A. , Ojala Tiina H. , Jahnukainen Timo , Hillman Paul R. 
Published: February 2023

AbstractBackgroundRenal‐hepatic‐pancreatic dysplasia type 2 (RHPD2) is a rare condition that has been described in the literature disproportionately in perinatal losses. The main features of liver and kidney involvement are well described, with cardiac malformations and cardiomyopathy adding additional variation to the phenotype. Many patients reported are within larger cohorts of congenital anomalies of kidney and urinary tract (CAKUT) or liver failure, and with minimal phenotypic and clinical course data.MethodsAn independent series of phenotypes and prognosis was aggregated from the literature. In this literature review, we describe an additional patient with RHPD2, provide a clinical update on the oldest known living patient, and report the cumulative phenotypes from the existing published patients.ResultsWith now examining the 17 known patients in the literature, 13 died within the perinatal period‐pregnancy to one year of life. Of the four cases living past the first year of life, one case died at 5 years secondary to renal failure, the other at 30 months secondary to liver and kidney failure. Two are currently alive and well at one year and 13 years. Two cases have had transplantation with one resulting in long‐term survival.ConclusionsThese patients serve to expand the existing phenotype of RHPD2 as a perinatal lethal condition into a pediatric disorder with variable expressivity. Additionally, we introduce the consideration of transplantation and outcomes within this cohort and future patients.
Partial tibial nerve transfer for iatrogenic peroneal nerve palsy after endovenous laser ablation for varicose veins of the lower extremity: A case report
Authors: Uemura Takuya , Miyashima Yusuke , Konishi Sadahiko , Takamatsu Kiyohito , Nakamura Hiroaki 
Published: February 2023

AbstractPostprocedural peroneal nerve palsy after endovenous laser ablation (EVLA) for varicose veins is rare and is associated with poor functional recovery. There have been no reports using tibial nerve transfer for iatrogenic peroneal nerve palsy after EVLA. Herein, we present a case with peroneal nerve injury after EVLA, which was successfully treated by partial tibial nerve transfer for the first time. A 75‐year‐old female presented with a right foot drop immediately after EVLA of the lesser saphenous vein. The ankle and toe dorsiflexion had a muscle grade of M0 on the British Medical Research Council muscle scale, without voluntary motor unit action potentials (MUAP) in the tibialis anterior (TA) muscle on the needle electromyography. Three months after the injury, surgical nerve exploration revealed a damaged common peroneal nerve with discoloration and scarring at the fibular head. Intraoperative deep peroneal nerve stimulation confirmed the absence of compound muscle action potentials in the TA. The best functioning motor fascicles of the tibial nerve were transferred to the deep peroneal main trunk involving motor branches of the TA, extensor digitorum longus, and extensor hallucis longus (EHL) through the interosseous membrane. The postoperative course was uneventful, with no complications. After 3 months of surgery, nascent MUAP appeared in the TA. After 24 months, the patient regained the TA and EHL muscle function and ambulation without an ankle‐foot orthosis and tibial nerve deficits. Thus, our procedure may serve as an alternative to nerve grafting, tendon transfer, and orthoses for better management of the major neural complications associated with EVLA.
Hypofractionation and SABR: 25 years of evolution in medical physics and a glimpse of the future
Authors: Rong Yi , Ding Xuanfeng , Daly Megan E. 
Published: February 2023

AbstractAs we were invited to write an article for celebrating the 50th Anniversary of Medical Physics journal, on something historically significant, commemorative, and exciting happening in the past decades, the first idea came to our mind is the fascinating radiotherapy paradigm shift from conventional fractionation to hypofractionation and stereotactic ablative radiotherapy (SABR). It is historically and clinically significant since as we all know this RT treatment revolution not only reduces treatment duration for patients, but also improves tumor control and cancer treatment outcomes. It is also commemorative and exciting for us medical physicists since the technology development in medical physics has been the main driver for the success of this treatment regimen which requires high precision and accuracy throughout the entire treatment planning and delivery. This article provides an overview of the technological development and clinical trials evolvement in the past 25 years for hypofractionation and SABR, with an outlook to the future improvement.
Leadership styles and transformational leadership skills among nurse leaders in Qatar, a cross‐sectional study
Authors: Al‐Thawabiya Amer , Singh Kalpana , Al‐Lenjawi Badriya Abdulla , Alomari Albara 
Published: February 2023

AbstractAimThere is a continuing need to implement strategies that create opportunities to develop leadership in Qatar, and to build institutions that can produce effective health managers and leaders. The scarcity of information and studies relating to leadership in this major healthcare corporation must be addressed. This article aims to explore nursing leadership styles and transformational leadership skills among nursing leaders, in Qatar. The study was conducted from October 2020 to January 2021.DesignA cross‐sectional Study.MethodsA validated survey was administered to explore the prevalence of leadership styles and transformational leadership skills. Subsequent statistical data analysis achieved the research objectives. The Multi‐Factor Leadership Questionnaire (Western Journal of Nursing Research, 1996) was used as an online de‐identified validated questionnaire.ResultsEighty‐nine nurses completed the survey. The nurse leaders in this study exhibited leadership traits or qualities that confirm transformational leadership. Some nurse leaders also exhibited transactional and autocratic leadership styles. Directors of nursing exhibit higher levels of transformational leadership style than head nurses, while the latter is more likely to manifest an autocratic leadership style. This study indicates that a development roadmap is needed to transform more nursing leaders into transformational leaders, particularly head nurses, and to universally improve transformational leadership skills among all nursing staff members.
Convergence analysis of single rate and multirate fixed stress split iterative coupling schemes in heterogeneous poroelastic media
Authors: Almani Tameem , Kumar Kundan , Wheeler Mary F. 
Published: February 2023

AbstractRecently, the accurate modeling of flow‐structure interactions has gained more attention and importance for both petroleum and environmental engineering applications. Of particular interest is the coupling between subsurface flow and reservoir geomechanics. Different single rate and multirate iterative and explicit coupling schemes have been proposed and analyzed in the past. In addition, Banach fixed point contraction results were obtained for iterative coupling schemes, and conditionally stable results were obtained for explicit coupling schemes. In this work, we will consider the mathematical analysis of the single rate and multirate fixed stress split iterative coupling schemes for spatially heterogeneous poroelastic media. We will re‐establish the contractivity for both schemes in the localized case, and we will show that heterogeneities come at the expense of imposing more restricted conditions on the number of fine flow time steps that can be taken within one coarse mechanics time step in the multirate case. Our mathematical analysis is supplemented by numerical simulations validating our derived upper bounds. To the best of our knowledge, this is the first rigorous mathematical analysis of the multirate fixed‐stress split iterative coupling scheme in heterogeneous poroelastic media.
Bird bone artifact from the Late Eneolithic/Early Bronze Age site of Zók (Hungary)
Authors: Vitezović Selena , Bulatović Jelena , Mitrović Jovan D. 
Published: February 2023

AbstractBird bones were rarely used for production of artifacts, due to various reasons—they were much smaller and thinner than bones of mammals usually selected for tool production; they also have specific shapes and fine structure, inadequate for the majority of common artifact types. They were occasionally used for some specific objects, such as flutes, pipes, needle cases, and amulets. When it comes to the Eneolithic and Early Bronze Age periods in south‐eastern Europe, bird bone artifacts are rare; only few have been discovered thus far. In this paper, we will present one additional finding of a bird bone artifact, from the site of Zók–Gradina, situated in present‐day Hungary. Excavations carried out in 1920 by the National Museum in Belgrade revealed a multi‐period site, with major parts of the stratigraphic sequence belonging to the Late Eneolithic/Early Bronze Age Vučedol culture (2900–2500/2400 BC). Vučedol layers yielded relatively large quantities of worked bone, including one artifact produced from a bird bone, that will be presented here. The object in question was produced from the right radius of a Cygnus sp.; it is in the shape of an elongated tube; carefully cut at both ends. The function of this item is uncertain—it may have served as some sound‐producing instrument (flute), or it was some sort of a handle or needle case. It is interesting to note that bird representations, in particular, ornithomorphic vessels, are among the specific traits of the Vučedol culture; therefore, the choice of a bird bone for the production of this artifact may have had a certain symbolic significance as well.
Designing databases and using generalized estimating equations for entheseal datasets: An example from the Tiwanaku culture (AD 500–1100)
Authors: Becker Sara K. , Stull Kyra E. , Chu Elaine 
Published: February 2023

AbstractStudying entheseal changes (EC) in human skeletal remains involves questions surrounding how researchers should collect, process, and evaluate these data as there are no set standards. Osteoarcheological research should also be able to answer population‐level queries using entheses, such as if group A was moving their body in different ways from group B? Or are there age‐related tasks or gendered labors? However, not all entheseal data can be easily evaluated in this fashion. If researchers select one area of the body, they may not be able to discuss population‐level differences. In addition, if data are evaluated by each muscle attachment area throughout a body, the results can be overwhelming. Further, grouping EC may produce problems with statistical assumptions of independence. To address these design and scalar issues, we discuss proper database construction, including the importance for consistent data collection strategies and in anchoring individuals under a specimen number. We also show how generalized estimating equations (GEE) can address how individual‐level scores can be collected and population‐level research questions can be answered with entheseal marker data processed in SAS 9.4 or the free alternative, R. We utilize a sample of over 1200 adults from the Tiwanaku culture (AD 500–1100) of Bolivia and Peru. We demonstrate evaluating significant overall differences while also pinpointing specific EC by sex or by age at death to discuss various ways in which bodies moved in the past.
A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial
Authors: Roumans Kay H. M. , Veelen Anna , Andriessen Charlotte , Mevenkamp Julian , Kornips Esther , Veeraiah Pandichelvam , Havekes Bas , Peters Harry P. F. , Lindeboom Lucas , Schrauwen Patrick , Schrauwen‐Hinderling Vera B. 
Published: February 2023

AbstractObjectiveIncreasing overnight fasting time seems a promising strategy to improve metabolic health in individuals with nonalcoholic fatty liver (NAFL). Mechanisms underlying the beneficial effects of fasting may be related to larger fluctuations in hepatic glycogen and higher fat oxidation. This study investigated whether prolonging an overnight fast depletes hepatic glycogen stores and improves substrate metabolism in individuals with NAFL and healthy lean individuals.MethodsEleven individuals with NAFL and ten control individuals participated in this randomized crossover trial. After a 9.5‐hour or 16‐hour fast, hepatic glycogen was measured by using carbon‐13 magnetic resonance spectroscopy, and a meal test was performed. Nocturnal substrate oxidation was measured with indirect calorimetry.ResultsExtending fasting time led to lower nocturnal carbohydrate oxidation and higher fat oxidation in both groups (intervention × time, p < 0.005 for carbohydrate and fat oxidation). In both arms, the respiratory exchange ratio measured during the night remained higher in the group with NAFL compared with the control group (population p < 0.001). No changes were observed in hepatic glycogen depletion with a prolonged overnight fast in the group with NAFL or the control group.ConclusionsThese results suggest that acutely prolonging the overnight fast can improve overnight substrate oxidation and that these alterations are not mediated by changes in hepatic glycogen depletion.