bluuebunny/crossref_metadata_2025_split huggingface dataset:
MEANS OF PROVING MISUSE OF INSIDER INFORMATION
Authors: Брянская Е.В. 
Published: July 2023

Одним из главных направлений политики нашего государства является противодействие коррупции, которая имеет различные проявления. До сих пор коррупционная преступность относится к латентной, в связи с чем достаточно остро стоит вопрос о разработке средств доказывания по отдельным категориям уголовных дел. Универсальный алгоритм процессуальных и следственных действий выработать достаточно сложно, поскольку каждый факт преступной деятельности оригинален. Особое значение приобретает опыт взаимодействия органов уголовного преследования, суда (по вопросам разрешений в рамках судебного контроля), финансовых структур, в частности применительно к таким фактам, которые касаются неправомерного использования инсайдерской информации
One of the main directions of the policy of our state is the fight against corruption, which is expressed in various manifestations. However, until now, corruption crimes are classified as latent crimes. In this regard, the issue of developing means of proof for certain categories of criminal cases is quite acute. Of course, it is difficult to develop a universal algorithm for procedural and investigative actions, since each fact of criminal activity is original and it is difficult to impose a common template when investigating a specific criminal case. However, there are such facts of criminal acts that can be most effectively detected and investigated in hot pursuit, through confidential operational-search activities. Therefore, the experience of interaction between the criminal prosecution authorities, the court (on the issues of permits within the framework of judicial control), financial structures in relation to such facts that relate to the misuse of insider information is of particular importance.
Identificación de los factores determinantes en la producción lechera en la provincia de Pastaza
Authors: Segura Chávez Edison Oliver , Coronel Espinoza Billy Daniel , Heredia Rengifo Marco Gerardo , Landines Vera Edgar , Muñoz Rengifo Julio Cesar 
Published: July 2023

Con el objetivo de clasificar y tipificar las fincas lecheras en Pastaza – Ecuador se usó el Modelo Estadístico de Medición de Impactos (MEMI). Se determinaron tres factores: El “Rebaño y producción” explica el 38.7% de la varianza del sistema, definido por las variables: número de vacas, hembras a la reproducción, vacas en ordeño y producción de leche. En la “Situación edafoclimática” el 27.8% de la varianza y el 66.5% acumulada por el modelo ajustado se relaciona con: la pendiente, área compatible con el pastoreo, cárcavas y profundidad del suelo. Y el “Tamaño de la explotación” expone el 78.7% de la varianza acumulada. El índice de impacto contribuyó para determinar el comportamiento y los principales problemas que influyen en el desarrollo de las fincas. Al 50% de la distancia euclidiana en el dendograma se conforman cuatro grupos: Primero: En 47 fincas de 45 ha ubicadas al 16% de pendiente, con una profundidad del suelo 22 cm. y menor número de cárcavas 32.5 ha-1, el 86.4 % es compatible con el pastoreo, producen 22.3 miles de litros (ML) de leche. Segundo: 26 fincas, ubicadas en zonas con mayor pendiente 47%, con menores áreas en uso ganadero, 12.5 hembras a la reproducción y como consecuencia menor producción de leche 16.8 ML de leche. Poseen la menor profundidad del suelo 15.3 cm y 104.2 cárcavas (ha-1), poseen alto impacto negativo causado por la erosión. Tercero: 9 fincas de 137.3 ha promedio, 101.6 ha utilizan para la ganadería, 57.8% del área es compatible con el pastoreo. Los indicadores reproductivos son superiores y una producción Anual de 45.5 ML. Cuarto: 8 fincas con pendientes de 50.6%, 47.5% compatible con el pastoreo. Son las fincas con mayor producción anual de leche 53.5 miles de litros, pero mayor cantidad de cárcavas (ha-1).
An Open-labeled Clinical Study to Evaluate the Safety and Efficacy of “Anuloma DS” in Improving Constipation
Authors: Varuni BG  
Published: July 2023

Background: Constipation is a common gastrointestinal problem in the general population. Despite a plethora of well-established and safe treatment options, the improvement is not satisfactory for many patients. This has prompted interest in alternative therapeutic strategies for constipation. Methods: This open-label, non-comparative single-arm clinical study evaluated the efficacy and safety of the polyherbal formulation “Anuloma DS”, 1 tablet daily at bedtime, in improving bowel movements in 30 adult patients with functional constipation. Patients were evaluated at baseline (Visit 1, Day 0) and follow-ups during Visit 2 (Day 7 ± 2), Visit 3 (Day 14 ± 2) and Visit 4 (End of the Study) at Day 30 ± 2. Results: There was a significant increase in the mean of spontaneous bowel movement every week from day 7 to days 14 and 30. All constipation symptoms such as abdominal bloating (aadmana), abdominal pain/discomfort (aanaha), feeling of incomplete evacuation and straining during passing stool improved significantly as did the SGA and the PGA scores. Conclusion: Anuloma DS is highly effective for the treatment of chronic functional constipation. No treatment-related side effects were reported by the study participants.
Pogonias courbina sperm characteristcs in its first reproductive season
Authors: Benato Jhony Lisboa , Streit Jr Danilo , Teixeira Nathalia Dos Santos , Rodrigues Rômulo Batista , de Freitas Thaiza Rodrigues , Okamoto Marcelo , Rodrigues Ricardo , dos Santos Raquel Santos , Dantas Renata Villar , Balbinot Ana Paula de Abreu , de Oliveira Rodrigo Ribeiro Bezerra , Maltez Lucas Campos , Menossi Olivia , Sampaio Luis Andre 
Published: July 2023

Southern black drum (Pogonias courbina) is a species distributed along the western Atlantic Ocean, and it is the largest Sciaenidae observed in the coast of Rio Grande do Sul state, Brazil. However, it is listed as a vulnerable species at The IUCN Red List of Threatened Species™, and their fishing is prohibited. The objective of this study was to determine the sperm characteristics of P. courbina. Sperm samples of five young males (two-year-old fish) were collected through abdominal pressure. The sperm kinetics parameters were sperm motility (MOT) 10.7 ± 5.6%, curvilinear velocity (VCL) 120.07 ± 16.16 mm s ± 1, average path velocity (VAP) 75.64 ± 23.78 mm s ± 1, straight-line velocity (VSL) 62.49 ± 15.83 mm s ± 1, straightness (STR) 83.9 ± 5.3%, wobble (WOB) 61.9 ± 12.7%, beat cross frequency (BCF) 42.981 ± 4.627 Hz and progression (PRG) 1,805.4 ± 564.5 µm. The proportion of normal spermatozoa was 35.6 ± 6.1%. About the abnormalities observed, 22.7% occurred in the tail (short tail = 0.6 ± 0.5%, distally curled tail = 2.4 ± 1.6%, strongly curled tail = 1.9 ± 1.3%, broken tail = 7.9 ± 5.1%, folded tail = 5.5 ± 0.8%, loose tail = 4.4 ± 1.9%); 14.2% occurred in the head (degenerate head = 4.2 ± 1.6%, microcephaly = 1.8 ± 2.5%, loose head = 8.2 ± 2.1%) and 27.5% of the spermatozoa showed cytoplasmatic gouts (proximal gout = 20.0 ± 8.4%, distal gout = 7.5 ± 2.8%). Besides that, a correlation analysis was performed between sperm morphology and kinetics parameters, and the spermatozoa were measured for the morphometric parameters. There was a positive correlation between BCF and normal spermatozoa (r = 0.9269). A negative correlation occurred between BCF and loose head (r = −0.9047); WOB and strongly curled tail (r = −0.8911); and PROG and strongly curled tail (r = −0.9191). The morphometric measures found for the head were length of 2.50 ± 0.21 µm and width of 2.12 ± 0.22 µm, and for the tail it was length of 37.97 ± 2.01 µm. It was possible to verify that the animals have sperm characteristics that indicate reproductive aptitude, but an abnormal behavior on sperm activation and high presence of the cytoplasmic gout abnormality indicates that the animals are not fully mature in their first reproductive season. This work contributes to a better understanding of the P. courbina spermatic parameters, what can be allies to recovery this species population in nature and promote its production in fish farms.
Unraveling Mechanoluminescent Mechanisms in Doped CaZnOS Materials: Co‐Mediation of Trap‐Controlled and Non‐Trap‐Controlled Processes
Authors: Li Wei , Cai Yiyu , Chang Jianqing , Wang Shanshan , Liu Jianjun , Zhou Lei , Wu Mingmei , Zhang Jun‐Cheng 
Published: July 2023

AbstractDoped CaZnOS materials show great potential for mechanoluminescence (ML) applications spanning the ultraviolet‐visible‐near infrared (UV–vis–NIR) range. However, conflicting reports regarding the generation and reproducibility of ML hinder the understanding and practical utilization of these materials. To address this issue, a comprehensive characterization strategy combining NIR laser‐assisted de‐trapping, UV irradiation‐induced trap‐filling, in situ mechanical stimulation, and continuous ML recording is proposed. Herein, the ML behaviors of four representative doped CaZnOS materials (Mn2+, Bi3+, Er3+, and Ce3+) are investigated using this approach. The results reveal that de‐trapped materials exhibit non‐trap‐controlled ML, wherein ML intensity gradually weakens under successive mechanical stimuli without self‐recovery. In contrast, trap‐filled materials demonstrate both trap‐controlled ML and non‐trap‐controlled ML, with the former predominantly contributing to the overall ML intensity. Notably, trap‐controlled ML shows only partial recovery after trap filling. The non‐trap‐controlled ML is attributed to plastic ML and destructive ML phenomena, while explaining trap‐controlled ML through the carrier de‐trapping model. These results not only clarify conflicting reports but also provide clear insights into the ML properties and mechanisms of CaZnOS‐based materials, facilitating advancements in practical applications. Furthermore, the developed characterization strategy is expected to serve as a valuable reference for establishing standardized protocols to evaluate ML performance.
Reductive Denitrogenation of Six‐membered Cyclic Nitronates to Densely Substituted Dihydrofurans with Raney® Nickel/AcOH System
Authors: Pospelov Evgeny V. , Zhirov Alexander V. , Kamidolla Baglan , Sukhorukov Alexey Yu. 
Published: July 2023

AbstractA protocol for the synthesis of 2,3‐dihydrofurans by reductive denitrogenation/ring contraction of 6‐membered cyclic nitronates was developed. The process utilizes cheap Raney® nickel both as catalyst and stoichiometric agent without the need for high‐pressure equipment. The products are formed in high purity and column chromatography is often not required. Studies on the substrate scope, functional group tolerance, and mechanism were performed. The developed approach provides a straightforward two‐step access to densely substituted 2,3‐dihydrofurans from nitrostyrenes and alkenes.
Can limits of plant available water be inferred from soil moisture distributions?
Authors: Kukal Meetpal S. , Irmak Suat 
Published: July 2023

AbstractRobust assessment of crop water availability requires effective integration of soil moisture data within the range of field capacity (θFC) to permanent wilting point (θPWP). Emerging needs for spatiotemporally dynamic θFC and θPWP are difficult to achieve with lab determinations. Therefore, we used long‐term data from 182 sites across the United States to evaluate whether soil moisture extremes defined by 95th and 5th percentiles represent θFC and θPWP, respectively. Soil moisture extremes and lab‐measured θFC and θPWP were well correlated (R2 = 0.71−0.92), however, both 95th and 5th percentiles overestimated θFC and θPWP at most depths (RMSE = 6%–16% vwc). Percentiles of soil moisture distribution that corresponded to lab‐determined θFC and θPWP varied widely and were a function of precipitation received at the site and site‐ and soil‐depth specific clay content. These findings imply that while θFC and θPWP may not be broadly represented by soil moisture extremes (95th and 5th percentiles), there may be potential to statistically infer the positioning of θFC and θPWP within long‐term soil moisture distributions using biophysical determinants such as aridity and soil characteristics.
Narrative minireview of the current status of hyperbaric oxygen therapy for pregnant women
Authors: Yanagawa Youichi , Nunotani Marika , Abe Keiki , Hamada Michika , Ota Soichiro , Muramatsu Ken‐ichi , Takeuchi Ikuto , Nagasawa Hiroki , Ohsaka Hiromichi , Ishikawa Kouhei 
Published: July 2023

AbstractWe performed a narrative minireview for a PubMed search on March 31, 2023, using the keywords “pregnant” and “hyperbaric oxygen” to identify any related articles. Most reports have described pregnant women with carbon monoxide (CO) poisoning being treated by hyperbaric oxygen therapy (HBOT). HBOT helped improve the maternal condition and ensure normal fetal development. Some pregnant women with CO poisoning treated by HBOT suffered abortions or gave premature birth to low‐weight babies or with congenital malformations. However, these results were considered sequelae of CO poisoning, not HBOT. We hypothesized that for pregnant women facing a life‐threatening situation, for which the effectiveness of HBOT has previously been suggested, prioritizing the stabilization of the mother may also be beneficial for normal fetal development.
Influence of the π‐bridge and heteroatom on fluorene‐based donor‐acceptor polymers: Structure and optoelectronic properties
Authors: Pereira Myllena S. , Araujo Luis O. , Daros Mikaela , Torres Bruno B. M. , Coutinho Douglas J. , Macedo Andreia G. , Faria Roberto M. , Rodrigues Paula C. 
Published: July 2023

AbstractConjugated copolymers possess intriguing electronic characteristics that can be precisely modulated by manipulating their chemical structures. In this study, we explored two approaches for fine‐tuning the energy levels of these copolymers: the incorporation of heterocyclic moieties between the donor and acceptor units, and the substitution of a chalcogen atom in the acceptor unit. Specifically, we investigated the insertion of a thiophene along the polymer backbone and the replacement of sulfur with selenium in the acceptor unit. A series of copolymers were synthesized and thoroughly characterized using both experimental and theoretical methods. Partial density distribution of states analysis revealed that the inclusion of a thiophene significantly altered the HOMO level. Furthermore, the resulting Eg exhibited a decrease of approximately 0.8–0.9 eV compared to the copolymer without thiophene, indicating an enhanced planarization of the chain and increased conjugation length. Experimental data obtained from cyclic voltammetry demonstrated that both the conjugation length and the chalcogen atom in the acceptor unit played crucial roles in controlling the energy levels of the HOMO and LUMO. These findings establish a clear correlation between the chemical structure and the properties of the copolymers, demonstrating the potential for precise control and tailoring of their electronic characteristics.
Computer Vision Analysis of Rheumatoid Arthritis Synovium Reveals Lymphocytic Inflammation Is Associated With Immunoglobulin Skewing in Blood
Authors: Frezza Damon , DiCarlo Edward , Hale Caryn , Ramirez Daniel , Mehta Bella , Slater David , Habib Saimun , Frank Mayu O. , Spolaore Edoardo , Smith Melanie H. , Donlin Laura , Goodman Susan , Thompson James R. , Orange Dana E. 
Published: July 2023

ObjectiveWe sought to develop computer vision methods to quantify aggregates of cells in synovial tissue and compare these with clinical and gene expression parameters.MethodsWe assembled a computer vision pipeline to quantify five features encompassing synovial cell density and aggregates and compared these with pathologist scores, disease classification, autoantibody status, and RNA expression in a cohort of 156 patients with rheumatoid arthritis (RA) and 149 patients with osteoarthritis (OA).ResultsAll five features were associated with pathologist scores of synovial lymphocytic inflammation (P < 0.0001). Three features that related to the cells per unit of tissue were significantly increased in patients with both seronegative and seropositive RA compared with those with OA; on the other hand, aggregate features (number and diameter) were significantly increased in seropositive, but not seronegative, RA compared with OA. Aggregate diameter was associated with the gene expression of immunoglobulin heavy‐chain genes in the synovial tissue. Compared with blood, synovial immunoglobulin isotypes were skewed from IGHM and IGHD to IGHG3 and IGHG1. Further, patients with RA with high levels of lymphocytic infiltrates in the synovium demonstrated parallel skewing in their blood with a relative decrease in IGHGM (P < 0.002) and IGHD (P < 0.03) and an increase in class‐switched immunoglobulin genes IGHG3 (P < 0.03) and IGHG1 (P < 0.002).ConclusionHigh‐resolution automated identification and quantification of synovial immune cell aggregates uncovered skewing in the synovium from naïve IGHD and IGHM to memory IGHG3 and IGHG1 and revealed that this process is reflected in the blood of patients with high inflammatory synovium.image
Deep learning‐based prediction of H3K27M alteration in diffuse midline gliomas based on whole‐brain MRI
Authors: Huang Bowen , Zhang Yuekang , Mao Qing , Ju Yan , Liu Yanhui , Su Zhengzheng , Lei Yinjie , Ren Yanming 
Published: July 2023

AbstractBackgroundH3K27M mutation status significantly affects the prognosis of patients with diffuse midline gliomas (DMGs), but this tumor presents a high risk of pathological acquisition. We aimed to construct a fully automated model for predicting the H3K27M alteration status of DMGs based on deep learning using whole‐brain MRI.MethodsDMG patients from West China Hospital of Sichuan University (WCHSU; n = 200) and Chengdu Shangjin Nanfu Hospital (CSNH; n = 35) who met the inclusion and exclusion criteria from February 2016 to April 2022 were enrolled as the training and external test sets, respectively. To adapt the model to the human head MRI scene, we use normal human head MR images to pretrain the model. The classification and tumor segmentation tasks are naturally related, so we conducted cotraining for the two tasks to enable information interaction between them and improve the accuracy of the classification task.ResultsThe average classification accuracies of our model on the training and external test sets was 90.5% and 85.1%, respectively. Ablation experiments showed that pretraining and cotraining could improve the prediction accuracy and generalization performance of the model. In the training and external test sets, the average areas under the receiver operating characteristic curve (AUROCs) were 94.18% and 87.64%, and the average areas under the precision‐recall curve (AUPRC) were 93.26% and 85.4%.ConclusionsThe developed model achieved excellent performance in predicting the H3K27M alteration status in DMGs, and its good reproducibility and generalization were verified in the external dataset.
Unfolding emotions for creating happiness and quality of life in Malaysia's low‐income community using text mining
Authors: Shuhidan Shuhaida Mohamed , Lokman Anitawati Mohd , Hamidi Saidatul Rahah , Kadir Shamsiah Abd , Syahirah Sharifah , Alam Md. Mahmudul 
Published: July 2023

AbstractDetermining the true reasons for happiness that exist in different social groups is important, especially in the case of those groups where poverty strongly dominates people's well‐being and happiness. To understand the factors that determine happiness among poor communities, this study collected data in the form of 1,793 responses from low‐income communities, who constitute 40% of Malaysia's workforce. To ascertain the feelings and emotional responses of the target group, primary source data were collected based on a questionnaire survey utilising the Lokman Emotion Importance Quadrant (LEIQ™) model. The data were analysed using text mining techniques based on R‐Language software. According to the findings, happiness in Malaysian low‐income communities is primarily shaped by concerns about family matters such as success, care issues, education and so on. Interestingly, government financial support, money, income and work matters are only fifth in importance, and lastly, the least emphasis was put on the public transportation issue. To ensure the true happiness and wellbeing of people who are struggling financially, policymakers must provide not only financial assistance but also ensure a better future for their families: better healthcare, better incomes, keeping a roof over their heads, etc. This study will be useful to the government, development agencies, NGOs, international organisations and other stakeholders wanting to realise the United Nations' Sustainable Development Goals (SDGs) in Malaysia and similarly affected countries. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
The efficacy of radiation therapy using the Quad Shot regimen in cutaneous metastasis from parotid gland cancer: A case report
Authors: Okada Kohei , Takahashi Satoru , Endo Masashi , Fukuda Yukiko , Ogawa Kazunari , Kawahara Masahiro , Akahane Keiko , Nishino Hiroshi , Yamaguchi Hironori , Shirai Katsuyuki 
Published: July 2023

Key Clinical MessageCutaneous metastasis from malignant tumors can cause symptoms such as exudates, bleeding, and pain, which remarkably reduce patient's quality of life. Herein, we report a case in which radiation therapy using the Quad Shot regimen was effective in the treatment of cutaneous metastasis from parotid gland cancer.
Promoting Oxygen Reduction Reaction by Excitation of Localized Surface Plasmon of Shape‐ and Facet‐Controlled Octahedral Au@Pt Core‐Shell Nanocrystals
Authors: Kameyama Tatsuya , Sato Kentaro , Yamamoto Takahisa , Tamura Mamoru , Iida Takuya , Shoji Tatsuya , Tsuboi Yasuyuki , Torimoto Tsukasa 
Published: July 2023

AbstractMuch attention has been paid to the development of high‐performance electrocatalytic reactions by exploiting the plasmonic properties of noble metal nanoparticles. In this study, ultrathin Pt layers with different coverage ratios were prepared on plasmonic octahedral Au nanoparticles (NPs) by underpotential deposition (UPD) of Cu followed by redox replacement with Pt. The effect of the Cu UPD cycle on the deposited Cu and redox‐substituted Pt layers on octahedral Au NPs was investigated to evaluate the electrocatalytic activity of Pt‐decorated octahedral NPs for the oxygen reduction reaction (ORR). By varying the number of cycles of Cu UPD and Pt replacement, the coverage by the Pt layer on the Au NPs could be easily controlled. The resulting Pt‐coated octahedral Au NPs exhibited three times higher specific activity for ORR than commercial Pt/C nanocatalysts due to the deposited Pt layer reflecting the {111} plane of the core. The ORR activity of Pt‐coated octahedral Au NPs could be enhanced by photoexcitation with monochromatic LED irradiation, and the increase in enhancement factor was even greater when irradiated with a wavelength that could efficiently excite the localized surface plasmon resonance (LSPR) of the NPs. Analysis shows that this improvement is due to improved diffusion of oxygen to the electrode.