bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hematologic tests and their association with the severity of COVID-19 and periodontitis in hospitalized patients: a case–control study
Authors: Moradi Haghgoo Janet , Torkzaban Parviz , Farhadian Maryam , Rabienejad Nazli , Moosavi Sedeh Sayed Ali 
Published: July 2023

Abstract
Background
The presence of comorbidities, especially those with a chronic inflammatory nature such as periodontitis, can facilitate COVID-19 progression toward more severe forms. Both of these diseases can affect systemic health and alter hematological test results. In this study, we decided to investigate COVID-19 and periodontitis’ possible interaction with these alterations.

Methods
Hospitalized patients with a definitive diagnosis of COVID-19 were included. Controls had mild to moderate COVID-19, while cases had severe to critical COVID-19. Periodontal examination was done for each patient. Relevant medical and hematological data were extracted from patient’s hospital files.

Results
A total of 122 patients entered the final analysis. The minimum white blood cell counts were associated with the severity of periodontitis. The interaction between periodontitis and COVID-19 was associated with increased minimum white blood cell counts and decreased platelet counts. COVID-19 severity was associated with increased venous oxygen saturation, prothrombin time, the maximum partial thromboplastin time, the maximum and average urea, the maximum creatinine, the maximum potassium, and lactate dehydrogenase, and decreased sodium levels.

Conclusions
Results of this study showed that several blood parameters were associated with periodontitis, COVID-19, or the interaction between them.
Home-based upper limb stroke rehabilitation mechatronics: challenges and opportunities
Authors: Forbrigger Shane , DePaul Vincent G. , Davies T. Claire , Morin Evelyn , Hashtrudi-Zaad Keyvan 
Published: July 2023

AbstractInterest in home-based stroke rehabilitation mechatronics, which includes both robots and sensor mechanisms, has increased over the past 12 years. The COVID-19 pandemic has exacerbated the existing lack of access to rehabilitation for stroke survivors post-discharge. Home-based stroke rehabilitation devices could improve access to rehabilitation for stroke survivors, but the home environment presents unique challenges compared to clinics. The present study undertakes a scoping review of designs for at-home upper limb stroke rehabilitation mechatronic devices to identify important design principles and areas for improvement. Online databases were used to identify papers published 2010–2021 describing novel rehabilitation device designs, from which 59 publications were selected describing 38 unique designs. The devices were categorized and listed according to their target anatomy, possible therapy tasks, structure, and features. Twenty-two devices targeted proximal (shoulder and elbow) anatomy, 13 targeted distal (wrist and hand) anatomy, and three targeted the whole arm and hand. Devices with a greater number of actuators in the design were more expensive, with a small number of devices using a mix of actuated and unactuated degrees of freedom to target more complex anatomy while reducing the cost. Twenty-six of the device designs did not specify their target users’ function or impairment, nor did they specify a target therapy activity, task, or exercise. Twenty-three of the devices were capable of reaching tasks, 6 of which included grasping capabilities. Compliant structures were the most common approach of including safety features in the design. Only three devices were designed to detect compensation, or undesirable posture, during therapy activities. Six of the 38 device designs mention consulting stakeholders during the design process, only two of which consulted patients specifically. Without stakeholder involvement, these designs risk being disconnected from user needs and rehabilitation best practices. Devices that combine actuated and unactuated degrees of freedom allow a greater variety and complexity of tasks while not significantly increasing their cost. Future home-based upper limb stroke rehabilitation mechatronic designs should provide information on patient posture during task execution, design with specific patient capabilities and needs in mind, and clearly link the features of the design to users’ needs.
Comprehensive analysis of m6A regulators characterized by the immune microenvironment in Duchenne muscular dystrophy
Authors: Han Xu , Ji Guang , Wang Ning , Yi Le , Mao Yafei , Deng Jinliang , Wu Hongran , Ma Shaojuan , Han Jingzhe , Bu Yi , Fang Pingping , Liu Juyi , Sun Fanzhe , Song Xueqin 
Published: July 2023

Abstract
Background
Duchenne muscular dystrophy (DMD) is an X-linked, incurable, degenerative neuromuscular disease that is exacerbated by secondary inflammation. N6-methyladenosine (m6A), the most common base modification of RNA, has pleiotropic immunomodulatory effects in many diseases. However, the role of m6A modification in the immune microenvironment of DMD remains elusive.

Methods
Our study retrospectively analyzed the expression data of 56 muscle tissues from DMD patients and 26 from non-muscular dystrophy individuals. Based on single sample gene set enrichment analysis, immune cells infiltration was identified and the result was validated by flow cytometry analysis and immunohistochemical staining. Then, we described the features of genetic variation in 26 m6A regulators and explored their relationship with the immune mircoenvironment of DMD patients through a series of bioinformatical analysis. At last, we determined subtypes of DMD patients by unsupervised clustering analysis and characterized the molecular and immune characteristics in different subgroups.

Results
DMD patients have a sophisticated immune microenvironment that is significantly different from non-DMD controls. Numerous m6A regulators were aberrantly expressed in the muscle tissues of DMD and inversely related to most muscle-infiltrating immune cell types and immune response-related signaling pathways. A diagnostic model involving seven m6A regulators was established using LASSO. Furthermore, we determined three m6A modification patterns (cluster A/B/C) with distinct immune microenvironmental characteristics.

Conclusion
In summary, our study demonstrated that m6A regulators are intimately linked to the immune microenvironment of muscle tissues in DMD. These findings may facilitate a better understanding of the immunomodulatory mechanisms in DMD and provide novel strategies for the treatment.
Continuous renal replacement therapy with the adsorptive oXiris filter may be associated with the lower 28-day mortality in sepsis: a systematic review and meta-analysis
Authors: Wang Guizhong , He Yuxuan , Guo Qingling , Zhao Ying , He Jie , Chen Yue , Chen Weijia , Zhou Yi , Peng Zichong , Deng Ke , Guan Jianbin , Xie Wenting , Chang Ping , Liu Zhanguo 
Published: July 2023

Abstract
Background
The oXiris is a novel filter for continuous renal replacement therapy (CRRT) featuring an adsorption coating to adsorb endotoxins and remove inflammatory mediators. Given that no consensus has been reached on its potential benefits in treating sepsis, a meta-analysis was conducted to assess its impact on the clinical outcomes of this patient population.

Methods
Eleven databases were retrieved to find relevant observational studies and randomized controlled trials. The Newcastle–Ottawa Scale and the Cochrane Risk of Bias Tool were used to assess the quality of the included studies. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) process was employed to assess the certainty of evidence. The 28-day mortality was the primary outcome. Secondary outcomes were 7-, 14-, and 90-day mortality, length of intensive care unit (ICU) and hospital stay, ICU and hospital mortality, norepinephrine (NE) dose, interleukin-6 (IL-6) and lactate levels, and Sequential Organ Failure Assessment (SOFA) score.

Results
The meta-analysis, pooling data from 14 studies, involving 695 patients, showed significant reductions in 28-day mortality [odds ratio (OR) 0.53; 95% confidence interval (CI) 0.36–0.77, p = 0.001] and length of ICU stay [weighted mean difference (WMD) − 1.91; 95% CI − 2.56 to − 1.26, p < 0.001)] in patients with sepsis using the oXiris filter compared to other filters. Besides, the SOFA score, NE dose, IL-6 and lactate levels, and 7- and 14-day mortalities were lower in the oXiris group. However, the 90-day mortality, ICU and hospital mortality, and length of hospital stay were comparable. The quality assessment of the ten observational studies indicated intermediate to high quality (average Newcastle–Ottawa score: 7.8). However, all four randomized controlled trials (RCTs) had an unclear risk of bias. The evidence for all outcomes had a low or very low level of certainty because the original study design was mainly observational studies and the RCTs included had an unclear risk of bias and a small sample size.

Conclusion
The treatment with the oXiris filter during CRRT in sepsis patients may be associated with lower 28-, 7-, and 14-day mortalities, lactate levels, SOFA score, NE dose, and shorter length of ICU stay. However, due to the low or very low quality of evidence, the effectiveness of oXiris filters was still uncertain. Besides, no significant difference was observed for the 90-day mortality, ICU and hospital mortality, and length of hospital stay.
Biosynthesis approach of copper nanoparticles, physicochemical characterization, cefixime wastewater treatment, and antibacterial activities
Authors: Hassan Esraa , Gahlan Ahmed A. , Gouda Gamal A. 
Published: July 2023

AbstractThe aim of this paper is the green synthesis of copper nanoparticles (Cu NPs) via Quinoa seed extract. X-ray diffraction (XRD) results confirmed the production of the pure crystalline face center cubic system of the Cu NPs with an average crystallite size of 8.41 nm. Infrared spectroscopy (FT-IR) analysis confirmed the capping and stabilization of the Cu NPs bioreduction process. UV visible spectroscopy (UV–Vis). surface plasmon resonance revealed the absorption peak at 324 nm with an energy bandgap of 3.47 eV. Electrical conductivity was conducted assuring the semiconductor nature of the biosynthesized Cu NPs. Morphological analysis was investigated confirming the nano-characteristic properties of the Cu NPs as polycrystalline cubic agglomerated shapes in scanning electron microscopy (SEM) analysis. Transmission electron microscopy (TEM) analysis also was used to assess the cubic shapes at a particle size of 15.1 ± 8.3 nm and a crystallinity index about equal to 2.0. Energy dispersive spectroscopy (EDX) was conducted to investigate the elemental composition of the Cu NPs. As a potential utility of the biosynthesized Cu NPs as nano adsorbents to the removal of the Cefixime (Xim) from the pharmaceutical wastewater; adsorption studies and process parameters were being investigated. The following strategic methodology for maximum Xim removal was conducted to be solution pH 4, Cu NPs dosage 30 mg, Xim concentration 100 mg/L, and absolute temperature 313 K. The maximum monolayer adsorption capacity was 122.9 mg/g according to the Langmuir isothermal model, and the kinetic mechanism was pseudo-second-order. Thermodynamic parameters also were derived as spontaneous chemisorption endothermic processes. Antibacterial activity of the Xim and Xim@Cu NPs was investigated confirming they are highly potent against each Gram-negative and Gram-positive bacterium.
Impact of high intensity interval exercise with and without heat stress on cardiovascular and aerobic performance: a pilot study
Authors: Matias Alexs A. , Albin Isabelle F. , Glickman Leah , Califano Peter A. , Faller Justin M. , Layec Gwenael , Ives Stephen J. 
Published: July 2023

Abstract
Background
Heat stress during aerobic exercise training may offer an additional stimulus to improve cardiovascular function and performance in a cool-temperate environment. However, there is a paucity of information on the additive effects of high-intensity interval exercise (HIIE) and acute heat stress. We aimed to determine the effects of HIIE in combination with acute heat stress on cardiovascular function and exercise performance.

Methods
Twelve active (peak O2 consumption [VO2peak]: 47 ± 8 ml·O2/min/kg) young adults were counterbalanced to six sessions of HIIE in hot (HIIE-H, 30 ± 1 °C, 50 ± 5% relative humidity [RH]) or temperate conditions (HIIE-T, 20 ± 2 °C, 15 ± 10% RH). Resting heart rate (HR), HR variability (HRV), central (cBP) and peripheral blood pressure (pBP), peripheral mean arterial pressure (pMAP), pulse wave velocity (PWV), VO2peak, and 5-km treadmill time-trial were measured pre- and post-training.

Results
Resting HR and HRV were not significantly different between groups. However, expressed as percent change from baseline, cSBP (HIIE-T: + 0.9 ± 3.6 and HIIE-H: -6.6 ± 3.0%, p = 0.03) and pSBP (HIIE-T: -2.0 ± 4.6 and HIIE-H: -8.4 ± 4.7%, p = 0.04) were lower in the heat group. Post-training PWV was also significantly lower in the heat group (HIIE-T: + 0.4% and HIIE-H: -6.3%, p = 0.03). Time-trial performance improved with training when data from both groups were pooled, and estimated VO2peak was not significantly different between groups (HIIE-T: 0.7% and HIIE-H: 6.0%, p = 0.10, Cohen’s d = 1.4).

Conclusions
The addition of acute heat stress to HIIE elicited additive adaptations in only cardiovascular function compared to HIIE alone in active young adults in temperate conditions, thus providing evidence for its effectiveness as a strategy to amplify exercise-induced cardiovascular adaptations.
Clear cell endometrial carcinoma with high microsatellite instability in a complicated pregnancy: a case report
Authors: Weiss Fabian , Kaltofen Till , Kanitz Veronika , Schröder Lennard , Kost Bernd , König Alexander , Delius Maria , Mahner Sven , Alba Alejandre Irene 
Published: July 2023

Abstract
Background
Endometrial carcinomas are the most common female genital malignancies. They are very rare in pregnancy and worldwide less than 60 cases associated with pregnancy are published. No clear cell carcinoma has been described in a pregnancy with a live birth.

Case presentation
We present the course of a 43-year-old Uyghur female patient with the diagnosis of endometrial carcinoma with a deficiency in the DNA mismatch repair system in the pregnancy. The malignancy with clear cell histology was confirmed by biopsy following the delivery via caesarean section due to preterm birth of a fetus with sonographically suspected tetralogy of Fallot. Earlier whole exome sequencing after amniocentesis had shown a heterozygous mutation in the MSH2 gene, which was unlikely to be related to the fetal cardiac defect. The uterine mass was initially deemed an isthmocervical fibroid by ultrasound and was confirmed as stage II endometrial carcinoma. The patient was consequently treated with surgery, radiotherapy and chemotherapy. Six months after the adjuvant therapy, re-laparotomy was performed due to ileus symptoms and an ileum metastasis was found. The patient is currently undergoing immune checkpoint inhibitor therapy with pembrolizumab.

Conclusion
Rare endometrial carcinoma should be included in the differential diagnosis of uterine masses in pregnant women with risk factors.
Resourcefulness of propylprodigiosin isolated from Brevundimonas olei strain RUN-D1
Authors: Olukanni Olumide D. , Abiola Temitope , Dada Jonathan B. , Dare Peter A. , Ayoade Femi , Olukanni Adedayo T. 
Published: July 2023

AbstractA novel red-pigmented bacterium was isolated from a water sample collected at Osun River, Ede. Morphological and 16 S rRNA gene sequencing revealed that the bacterium is a strain of Brevundimonas olei, while its red pigment was identified using UV-visible, FTIR and GCMS as a derivative of propylprodigiosin. The maximum absorbance of 534 nm, the FTIR’s 1344 cm− 1 peak of prodigiosin’s methoxyl C-O interaction, and the molecular ions from GCMS confirmed the pigment’s identity. The pigments production was temperature-sensitive (25 °C), lost at > 28 °C, and in the presence of urea and humus. In addition, the pigment turned pink in the presence of hydrocarbons, while its red colour was retained with KCN and Fe2SO4, and enhanced by methylparaben. Furthermore, the pigment is stable in high temperature, salt, and acidic conditions, but changed to yellow in alkaline solution. The pigment, identified as propylprodigiosin (m/z 297), demonstrated broad-spectrum antibacterial activities against clinically important strains of Staphylococcus aureus (ATCC25923), Pseudomonas aeruginosa (ATCC9077), Bacillus cereus (ATCC10876), Salmonella typhi (ATCC13311), and Escherichia coli (DSM10974). The ethanol extract has the highest zones of inhibition of 29 ± 3.0, 26 ± 1.2, 22 ± 3.0, 22 ± 1.5, and 20 ± 2.0 mm, respectively. Furthermore, the acetone pigments interacted with cellulose and glucose such that increasing glucose concentrations showed linearity at 425 nm. Finally, the fastness of the pigments to fabrics was excellent, with percentage fadedness of 0 and − 43% light and washing tests, respectively, in the presence of Fe2SO4 as the mordant. The antibacterial nature of prodigiosin solutions and their good textile fastness to fabrics could be essential in manufacturing antiseptic materials such as bandages, hospital clothing and agricultural applications such as tubers preservation.Key points
Temporal climate conditions and spatial drought patterns across rangelands in pastoral areas of West Guji and Borana zones, Southern Ethiopia
Authors: Dejene Tesfaye , Dalle Gemedo , Woldeamanuel Teshale , Mekuyie Muluken 
Published: July 2023

AbstractClimate change and its variability adversely impact pastoral livelihoods, and understanding climate variability and its change is important to deduce policy implications for pastoral communities. Accordingly, the aim of this study was to investigate the temporal climate conditions and spatial patterns of drought across the rangelands in pastoral areas of West Guji and Borana Zones, Southern Ethiopia. Temporal climate conditions were performed at the rangeland level, and spatial drought patterns (distributions) were estimated across the sample Kebeles (Kebele is the smallest administrative unit in Ethiopia which works in the Duda rangeland) and Reeras (Reeras refer to the smallest customary administrative unit in the Borana Zonal administration) structures. Station-satellite temperature and rainfall data (38 years from 1981 to 2018) were obtained from the Ethiopian Meteorological Agency. For data analysis, the Mann–Kendall trend test was employed to test rainfall, temperature and drought patterns, while Sen’s slope was used to test their magnitude of change, and coefficient of variation was employed to estimate rainfall and temperature variability. Standardized precipitation index was used to estimate drought event, while inverse distance-weighted method was used to estimate spatial drought patterns. The study reveals very high temporal rainfall variability with notable disparities in the rangelands mainly attributed to climate change. Besides, the study area exhibits high spatial variability of drought signifying agro-ecological characteristics in the rangelands. In the Duda and Gomole rangelands, annual rainfall increased non-significantly by 0.01 and 0.03 mm per annum, respectively. The annual minimum temperature in both Duda and Gomole increased significantly by 0.008 and 0.007 ℃ per year, respectively, albeit the annual maximum temperature in the rangelands decreased non-significantly by 0.02 and 0.009 ℃ per annum. Both rangelands experienced high annual rainfall variability, increasing annual minimum temperature, drought frequency and severity. Therefore, the outcome of the study is believed to be vital for identifying drought hotspot areas in the rangelands and devising strategies that help to reduce drought impacts on pastoral communities in Southern Ethiopia.
Experimental Toughness and Durability Evaluation of FRC Composite Reinforced with Steel–Polyester Fiber Combination
Authors: Christopher Chella Gifta , Gopal Ramesh , Sadasivam Sasivaradhan , Devi Keerthika Esakki A. K. , Dinesh Kumar P. 
Published: July 2023

AbstractThis study investigates the influence of steel and polyester fibers on the mechanical and durability properties of steel–polymer hybrid fiber reinforced concrete (HyFRC) and toughness under indirect tensile loading conditions. Steel and Polyester fibers are used as a single type (FRC) and in combination (HyFRC) in an M45 grade composite with the addition of fly ash and silica fume as a supplementary cementitious material. Steel as a single fiber exhibited a 10% improvement in compressive strength for a 0.75% volume fraction and a maximum of 14% improvement for a 0.5% volume fraction in comparison to plain concrete. The toughness under split tension capacity was enhanced between 26 and 72% for hybrid fibers in comparison with polyester fiber, and it was between 10 and 18% when compared to the steel fiber reinforcement. Water sorpitivity results were improved with the presence of hybrid fiber. Electrical resistivity decreases with the increase in fiber content and the addition of steel fiber in hybrid FRC increases the conductivity value 1.65–2.23 times greater than the control concrete because of the free movement of electrons.