bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modifiable risk‐attributable and age‐related burden of lung cancer in China, 1990–2019
Authors: Wang Chenran , Chang Yuting , Ren Jingyu , Wu Zheng , Zheng Yadi , Luo Zilin , Qin Chao , Cao Wei , Wang Fei , Xu Yongjie , Zhao Liang , Dong Xuesi , Xia Changfa , Li Jiang , Ren Jiansong , Shi Jufang , Li Jibin , Zou Kaiyong , Chen Wanqing , Tan Fengwei , Li Ni , He Jie 
Published: May 2023

AbstractBackgroundThere were limited studies on the quantification of the modifiable and nonmodifiable lung cancer burden over time in China. Furthermore, the potential effect of risk factor reduction for lung cancer on gains in life expectancy (LE) remains unknown.MethodsThis study explored temporal trends in lung cancer deaths and disability‐adjusted life years (DALY) attributable to modifiable risk factors from 1990 to 2019, based on the 2019 Global Burden of Disease Study. The abridged period life table method was used to quantify the effect of risk factors on LE. The authors used the decomposition approach to estimate contributions of aging metrics to change in the lung cancer burden.ResultsNationally, the majority of lung cancer deaths and DALYs were attributable to behavioral and environmental risk clusters. Potential gains in life expectancy (PGLE) at birth would be 0.78 years for males and 0.35 years for females if the exposure to risk factors was mitigated to the theoretical minimum level. Tobacco use had the most robust impact on LE for both sexes (PGLE: 0.71 years for males and 0.19 years for females). From 1990 to 2019, risk‐attributable age‐standardized death and DALY rates of lung cancer showed an increasing trend in both sexes; adult population growth imposed 245.9 thousand deaths and 6.2 million DALYs for lung cancer.ConclusionsThe modifiable risk‐attributable lung cancer burden remains high in China. Effective tobacco control is the critical step toward addressing the lung cancer burden. Adult population growth was the foremost driver of transition in the age‐related lung cancer burden.Plain Language Summary

We estimate the lung cancer burden attributable to modifiable and nonmodifiable contributors and the effect of risk factor reduction for lung cancer on the life expectancy in China.

The findings suggest that the majority of lung cancer deaths and disability‐adjusted life years were attributable to behavioral risk clusters, and the risk‐attributable lung cancer burden increased nationally from 1990 to 2019.

The average gains in life expectancy would be 0.78 years for males and 0.35 years for females if the exposure to risk factors for lung cancer was reduced to the theoretical minimum risk exposure level.

Adult population growth was identified as the foremost driver of variation in the aging lung cancer burden.
Stereotactic ablative radiotherapy before resection to avoid delay for early‐stage lung cancer or oligometastases during the COVID‐19 pandemic: Pathologic outcomes from the SABR‐BRIDGE protocol
Authors: Kidane Biniam , Gerard Ian J. , Spicer Jonathan , Kim Julian O. , Fiset Pierre O. , Wawryko Paul , Cecchini Matthew J. , Inculet Richard , Abdulkarim Bassam , Fortin Dalilah , Qiabi Mehdi , Qing Gefei , Enns Stephanie , Bashir Bashir , Tankel James , Wakeam Elliot , Warner Andrew , Kopek Neil , Yaremko Brian P. , Rodrigues George B. , Laba Joanna M. , Qu Melody , Malthaner Richard A. , Palma David A. 
Published: May 2023

AbstractBackgroundDuring coronavirus disease 2019 (COVID‐19)–related operating room closures, some multidisciplinary thoracic oncology teams adopted a paradigm of stereotactic ablative radiotherapy (SABR) as a bridge to surgery, an approach called SABR‐BRIDGE. This study presents the preliminary surgical and pathological results.MethodsEligible participants from four institutions (three in Canada and one in the United States) had early‐stage presumed or biopsy‐proven lung malignancy that would normally be surgically resected. SABR was delivered using standard institutional guidelines, with surgery >3 months following SABR with standardized pathologic assessment. Pathological complete response (pCR) was defined as absence of viable cancer. Major pathologic response (MPR) was defined as ≤10% viable tissue.ResultsSeventy‐two patients underwent SABR. Most common SABR regimens were 34 Gy/1 (29%, n = 21), 48 Gy/3–4 (26%, n = 19), and 50/55 Gy/5 (22%, n = 16). SABR was well‐tolerated, with one grade 5 toxicity (death 10 days after SABR with COVID‐19) and five grade 2–3 toxicities. Following SABR, 26 patients underwent resection thus far (13 pending surgery). Median time‐to‐surgery was 4.5 months post‐SABR (range, 2–17.5 months). Surgery was reported as being more difficult because of SABR in 38% (n = 10) of cases. Thirteen patients (50%) had pCR and 19 (73%) had MPR. Rates of pCR trended higher in patients operated on at earlier time points (75% if within 3 months, 50% if 3–6 months, and 33% if ≥6 months; p = .069). In the exploratory best‐case scenario analysis, pCR rate does not exceed 82%.ConclusionsThe SABR‐BRIDGE approach allowed for delivery of treatment during a period of operating room closure and was well‐tolerated. Even in the best‐case scenario, pCR rate does not exceed 82%.
Acrylic colors for peace: Non‐invasive study of an outdoor mural painting
Authors: Cano Nathael , de Lucio Oscar G. , Pérez Miguel , Mitrani Alejandro , Nagaya Alan , Sil José Luis Ruvalcaba , Medina Ricardo 
Published: May 2023

AbstractIn 1952, contemporary artist Federico Silva (Mexico City, 1923–2022) carried out the first outdoor mural painting: The technique at the service of peace. At the end of 2021, the project for the study and conservation of this mural began with a diagnosis of its conservation, which was done through a multi‐technique study based on the experience acquired in research projects from other contemporary mural paintings. This included the proposal of an adequate conservation strategy to resolve the stability of the painting, since the behavior of the synthetic paints exposed to the different effects of the outdoor environment has altered the perception, form and meaning of the mural. Main results from this approach by documentation and global examination with Visible Imaging and Digital Microscopy, allowed us to describe the color palette and its alterations. Additional examination of cross sections acquired from this mural, allowed a material characterization by means of optical microscopy (OM), micro‐hyperspectral imaging, Fourier transformed infrared spectroscopy and X‐ray fluorescence spectroscopies.
Spectral reflectance estimation from non‐raw color images with nonlinearity correction
Authors: Xu Peng , Hosseinkhani Jila , Rajan Sreeraman , Wang Hangjun , Yang Jie 
Published: May 2023

AbstractThe spectral reflectance is recognized as the fingerprint of an object surface and has been used to achieve accurate color measurement in textile and other fields. Spectral reflectance can be recovered from color images to preserve high spectral and spatial resolutions simultaneously. However, a color camera commonly supplies a non‐raw color image, which is non‐linear with respect to the scene radiance, and is inappropriate for quantitative analysis. In this study, for non‐raw color images, different nonlinearity correction models are designed and evaluated with respect to different spectral estimation algorithms. The colorimetric and spectral accuracy of spectral estimation after the nonlinearity correction is assessed through both simulation and practical experiments. In the simulation, a large number of spectral images from several datasets are employed to directly verify the effectiveness of the nonlinearity correction. In the practical experiments, the spectral estimation accuracy following the nonlinearity correction is verified directly and indirectly based on actual color images. The resulting linear color image data after the nonlinearity correction can provide better spectral estimation accuracy especially for the PI algorithm with one power‐function based model. Besides, the combination of the simple PI algorithm with the power‐function based model can exceed other combinations comprising complex algorithms and models in both accuracy and efficiency. For the linear color image data, the PI algorithm even surpasses the deep learning‐based methods in certain metric, thus indicating a shallow relationship exists between the linear color image data and the spectral reflectance.
Effect of Food on the Pharmacokinetics of Limertinib (ASK120067) and its Main Metabolite in Healthy Chinese Volunteers
Authors: Yang Dandan , Chen Wenjun , Ruan Zourong , Guo Haifang , Jiang Qianqian , Lou Honggang , Jiang Bo 
Published: May 2023

AbstractLimertinib (ASK120067) is a newly developed third‐generation epidermal growth factor receptor tyrosine kinase inhibitor. This phase I, open‐label, 2‐period crossover study was conducted to evaluate the effect of food on the pharmacokinetics (PK) of limertinib and its active metabolite CCB4580030 in Chinese healthy volunteers (HVs). HVs were randomly assigned (1:1) to receive a single dose of limertinib (160 mg) under the fasted state in period 1 and fed condition in period 2, or vice versa. Twenty‐four HVs were enrolled, and 20 HVs completed both study periods. PK were assessed before dosing and ≤72 hours after dosing. PK parameters were analyzed by a noncompartmental method. Limertinib was absorbed faster in the fasted state compared with the fed state. The geometric mean ratios (fed/fast) of maximum concentration, area under the plasma concentration–time curve from time 0 to the last quantifiable concentration, and area under the plasma concentration–time curve from time 0 to infinity for ASK120067 were 145.5%, 145.4%, and 141.9%, respectively. Geometric mean ratios of the PK parameters of CCB4580030 were >125.00% and 90% confidence intervals were outside the preset bioequivalent range. Safety profiles were similar in both prandial states, and limertinib was well tolerated. Food reduced the rate and increased the extent of limertinib absorption following oral administration. Whether limertinib can be administered regardless of prandial state in patients warrants further investigation of efficacy and safety.
Reverse Dual‐Ion Battery Enabled by Reversing the Cation/Anion Storage Mechanism in an Aqueous ZnCl2 Water‐in‐Salt Electrolyte
Authors: Sethi Asis , Kumar U. Anil , Dhavale Vishal M. 
Published: May 2023

AbstractDual ion batteries (DIBs) have garnered significant attention from researchers due to their unique ability to store charges using electrolyte‐born ions, making them promising candidates for grid storage applications. However, despite extensive efforts to explore DIBs with various electrolytes, such as organic, aqueous, gel polymer etc., challenges such as electrolyte decomposition and poor stability of anode materials in aqueous electrolytes remain unresolved. To address these issues, we report a novel approach utilizing a flip‐cum‐reverse sequence of anion/cation storage chemistry in a ZnCl2 water‐in‐salt electrolyte (ZnCl2‐WiSE)‐based reverse dual ion battery (RDIB), employing Zn‐based Prussian blue analogue i. e., Zn3[Fe(CN)6]2 and ferrocene‐carbon composite (FcC) as cathode and anode electrodes, respectively. The RDIB operates in the opposite direction compared to conventional DIBs, offering a fresh perspective. Through our investigations, we discovered that increasing the concentration of ZnCl2‐WiSE [ZnCl2‐WiSE] resulted in a positive shift of 270 mV in the redox potential for cation/anion (de)insertion at the cathode, and a negative shift of 70 mV at the anode, indicating enhanced performance. Remarkably, the RDIB operate in 10 m ZnCl2‐WiSE exhibited an impressive energy density of 23 Wh kg−1, showcasing the potential of this approach for high‐performance energy storage.
Fractional‐order LC filter modeling, implementation, and analysis for distributed power generation system
Authors: Govind D. , Suryawanshi H. M. , Nachankar P. P. , Narayana Chintalpudi L. , Singhal Ankit 
Published: May 2023

SummaryThis paper proposes a comprehensive mathematical modeling and analysis considering fractional‐order LC filters (FOLCF) in the utility grid‐connected mode (UGCM) and the standalone mode (SM) of operation for the distributed power generation system. The fractional‐order behavior of LC filter elements helps to more properly depict a practical inductor or capacitor than the integer‐order LC filters (IOLCF) in the distributed power generation system. The fractional‐order model of UGCM and SM is obtained in the synchronously rotating reference frame using coordinate transformation. A detailed stability and time domain analysis is performed on the developed FO UGCM and SM mathematical models. The stability of fractional‐order LC filters increases for orders
less than 1, based on the performance evaluation of the FO and IO mathematical models for UGCM and SM with the corresponding designed controller gains. The FOLCFs are approximated using the constant phase element method, which gives a compact and exact approximation of the fractional‐order inductor and capacitor elements. The implementation of FOLCF with UGCM and SM operations verifies the effectiveness of the proposed model in real‐time simulation. The results show the FOLCF model provides better dynamic tracking and disturbance rejection response than the IOLCF model. Hence, the FOLCF model imparts immunity against local load disturbances to regulate the point of common coupling voltage and frequency in standalone mode. Furthermore, a significant improvement in % total harmonic distortion is also observed in grid current and load voltage.
The effect of sleep disorders on dementia risk in patients with traumatic brain injury: A large‐scale cohort study
Authors: Mollayeva Tatyana , Tran Andrew , Hurst Mackenzie , Escobar Michael , Colantonio Angela 
Published: May 2023

AbstractIntroductionWe investigated the association between sleep disorders (SDs) and incident dementia in adults with traumatic brain injury (TBI).MethodsAdults with a TBI between 2003 and 2013 were followed until incident dementia. Sleep disorders at TBI were predictors in Cox regression models, controlling for other dementia risks.ResultsOver 52 months, 4.6% of the 712,708 adults (59% male, median age 44, <1% with SD) developed dementia. An SD was associated with a 26% and a 23% of increased risk of dementia in male and female participants (hazard ratio [HR] 1.26, 95% confidence interval [CI] 1.11–1.42 and HR 1.23, 95% CI 1.09–1.40, respectively). In male participants, SD was associated with a 93% increased risk of early‐onset dementia (HR 1.93, 95% CI 1.29–2.87); this did not hold in female participants (HR 1.38, 95% CI 0.78–2.44).DiscussionIn a province‐wide cohort, SDs at TBI were independently associated with incident dementia. Clinical trials testing sex‐specific SD care after TBI for dementia prevention are timely.Highlights
TBI and sleep disorders are linked to each other, and to dementia.
It is unclear if sleep disorders pose a sex‐specific dementia risk in brain injury.
In this study, presence of a sleep disorder increased dementia risk in both sexes.
The risk differed by type of sleep disorder, which differed between the sexes.
Sleep disorder awareness and care in persons with brain injury is vital for dementia prevention.
Potentially inappropriate medications use in a psychiatric elderly care hospital: A cross‐sectional study using Beers criteria
Authors: Yaghi Gracia , Chahine Bahia 
Published: May 2023

AbstractBackground and AimsPotentially inappropriate medications (PIMs) carry risks that outweigh any potential benefits when compared to safer or more effective alternative treatments. Adverse drug events are more likely to occur in older adults with psychiatric diseases due to multimorbidity, polypharmacy, and age‐related changes in drug pharmacokinetics and pharmacodynamics. The aim of this study was to assess the prevalence and risk factors of PIM use in an aged care hospital's psychogeriatric division, using the American Geriatrics Society Beers criteria 2019.MethodsThis cross‐sectional study was conducted on all current inpatients, having a mental disorder and aged ≥65 years, in one elderly care hospital in Beirut, from March to May 2022. Medications, sociodemographic and clinical characteristics were collected from patients' medical records. PIMs were evaluated based on Beers criteria 2019. Independent variables were described using descriptive statistics. Factors associated with PIM use were identified by bivariate analysis followed by binary logistic regression. A two‐sided p value <0.05 was considered statistically significant.ResultsThe study included 147 patients, with a mean age of 76.3 years, 46.9% of them having schizophrenia, 68.7% using 5 or more drugs and 90.5% taking at least 1 PIM. The most prescribed PIMs were antipsychotics (40.2%), anticholinergics (16%), and antidepressants (7.8%). PIM use was significantly associated with polypharmacy (AOR = 20.88, 95% CI: 1.22−357.87, p = 0.04) and anticholinergic cognitive burden (ACB) score (AOR = 7.25, 95% CI: 1.13−46.52, p = 0.04).ConclusionPIMs were highly prevalent among hospitalized Lebanese psychiatric elderly. Polypharmacy and ACB score were the determinants of PIM use. A multidisciplinary medication review led by a clinical pharmacist could reduce PIM use.
Natural convective heat transfer and fluid flow in a porous medium filled corrugated enclosure: Effect of discrete heat sources
Authors: Choudhary Pankaj , Ray Rajendra K. 
Published: May 2023

AbstractIn this work, we investigate the two‐dimensional unsteady natural convective fluid flow problem in a porous‐corrugated enclosure with a fixed sinusoidal heated upper wall. The corrugations of the enclosure are discretely heated while vertical walls are maintained isothermally cold. Subject to where the heat sources are located, five different cases are taken into consideration. The vorticity–streamfunction equations are discretized using a transformation‐free higher order compact approach, and the hybrid BiCGSTAB technique is used to solve the system of algebraic equations that derives from the numerical discretization. To validate our findings, we first compare them to previously published numerical and experimental data. The numerically simulated outcomes are then examined over a variety of essential parameters, such as the Darcy (10−5 ≤ Da ≤ 10−1), Rayleigh (103 ≤ Ra ≤ 106), and Prandtl (0.1 ≤ Pr ≤ 10) numbers. Symmetric and asymmetric fluid flow phenomena are observed. Asymmetric flow phenomenon can be caused by miscible or non‐miscible movements of lighter fluids by heavier fluids, or almost exclusively by nonuniform buoyancy‐driven forces caused by density variations that have arisen because of variations in fluid temperature. The averaged Nusselt value for Case 1 and Case 5 exhibits the highest percentage ratio. The thermal boundary layer is strongly affected by compression, dispersion, suppression, the zone of stratification, and the outweighing of isotherms. The simulated results are visualized by stream functions, isotherms, local and averaged Nusselt number plots.
Association of Preterm Birth and Low Birthweight with Bone Fractures during Childhood
Authors: Kuitunen Ilari , Sund Reijo , Sankilampi Ulla 
Published: May 2023

ABSTRACTPreterm birth and low birthweight have been associated with increased fracture risk in children. Our aim was to analyze bone fractures during childhood in preterm, and low‐birthweight newborns compared to full‐term and normal‐birthweight newborns. We conducted a nationwide register‐based cohort study in Finland from 1998 to 2017 and utilized the Medical Birth Register and Care Register for Health Care. All newborns alive 28 days after birth were included, and data on all fracture visits in specialized healthcare units were gathered. Incidences per 100,000 person‐years with 95% confidence intervals (CI) were calculated, and comparisons were made by incidence rate ratios (IRRs). Kaplan–Meier analysis was used to analyze the timing of fractures during childhood (0–20 years). We included a total of 997,468 newborns and 95,869 fractures; the mean follow‐up was 10.0 years, and the overall incidence of fractures was 963 per 100,000 person‐years. Very preterm (<32 gestational weeks) newborns had 23% lower fracture incidence than term newborns (IRR 0.77; CI: 0.70–0.85). Preterm newborns (32 to 36 gestational weeks) had a fracture rate (IRR 0.98; CI: 0.95–1.01) similar to that of term newborns. Birthweight showed a linear increase in the fracture rates as newborns with birthweight less than 1000 g had the lowest fracture incidence of 773 per 100,000 person‐years and the highest incidence (966 per 100,000 person‐years) was among newborns with birthweight 2500 g or more. Children born very preterm or with extremely low birthweight have in general a lower fracture incidence during childhood compared to children born full term and with normal birthweight. These findings possibly reflect, in addition to improvements of neonatal intensive care and early nutrition, the fact that childhood fracture incidences are more dependent on issues other than early life events. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
miR‐196b‐5p Regulates Osteoblast and Osteoclast Differentiation and Bone Homeostasis by Targeting SEMA3A
Authors: Xie Yan , Zhou Jie , Tian Lijie , Dong Yuan , Yuan Hairui , Zhu Endong , Li Xiaoxia , Wang Baoli 
Published: May 2023

ABSTRACTmiR‐196b‐5p plays a role in various malignancies. We have recently reported its function in regulating adipogenesis. However, it remains to be clarified whether and how miR‐196b‐5p affects bone cells and bone homeostasis. In this study, in vitro functional experiments showed an inhibitory effect of miR‐196b‐5p on osteoblast differentiation. Mechanistic explorations revealed that miR‐196b‐5p directly targeted semaphorin 3a (Sema3a) and inhibited Wnt/β‐catenin signaling. SEMA3A attenuated the impaired osteogenesis induced by miR‐196b‐5p. Osteoblast‐specific miR‐196b transgenic mice showed significant reduction of bone mass. Trabecular osteoblasts were reduced and bone formation was suppressed, whereas osteoclasts, marrow adipocytes, and serum levels of bone resorption markers were increased in the transgenic mice. The osteoblastic progenitor cells from the transgenic mice had decreased SEMA3A levels and exhibited retarded osteogenic differentiation, whereas those marrow osteoclastic progenitors exhibited enhanced osteoclastogenic differentiation. miR‐196b‐5p and SEMA3A oppositely regulated the expression of receptor activator of nuclear factor‐κB ligand and osteoprotegerin. The calvarial osteoblastic cells expressing the transgene promoted osteoclastogenesis, whereas the osteoblasts overexpressing Sema3a inhibited it. Finally, in vivo transfection of miR‐196b‐5p inhibitor to the marrow reduced ovariectomy‐induced bone loss in mice. Our study has identified that miR‐196b‐5p plays a key role in osteoblast and osteoclast differentiation and regulates bone homeostasis. Inhibition of miR‐196b‐5p may be beneficial for amelioration of osteoporosis. © 2023 American Society for Bone and Mineral Research (ASBMR).