bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of extracellular matrix of fish swim bladders by decellularization with supercritical carbon dioxide
Authors: Han Yuqing , Zhang Bingyan , Li Jinjin , Cen Lian , Zhao Ling , Xi Zhenhao 
Published: February 2023

AbstractFish swim bladders used to be considered as byproducts or waste in fishery; however, they are potential materials for biological medicine with abundant collagen. In this work, an efficient noncytotoxic decellularization process using sodium dodecyl sulfate (SDS) ternary system assisted with supercritical carbon dioxide (scCO2) as the green extraction fluid and ethanol (ET) as the cosolvent has been developed to harvest acellular fish swim bladders (AFSBs). The experimental results show that the tissue treated by SDS assisted with scCO2 and ethanol at 37 °C and 25 MPa can be decellularized thoroughly and maintains intact fibers and uniform pore distribution, which resulting in a tensile strength of 5.61 MPa and satisfactory biocompatibility. Meanwhile, the residual SDS content in scCO2/SDS/ET ternary system is 0.0122% which is significantly lower than it in scCO2/SDS system due to the enhanced mass transfer rate of SDS in tissues by scCO2 with ethanol. The synergy between SDS and ethanol can enhance the diffusion coefficient and the solubility of SDS in scCO2, which reduced the contact time between SDS and tissues. Meaningfully, the results obtained in this work can not only provide a novel strategy to produce acellular matrix with superior properties, but also offer a further understanding of the decellularization through scCO2 extraction processing with the synergy of suitable detergent/cosolvent.
Graphical Abstract
Sarcomatoid renal cell carcinoma: MRI features and their association with survival
Authors: Cheng Monica , Duzgol Cihan , Kim Tae-Hyung , Ghafoor Soleen , Becker Anton S. , Causa Andrieu Pamela I. , Gangai Natalie , Jiang Hui , Hakimi Abraham A. , Vargas Hebert A. , Woo Sungmin 
Published: February 2023

Abstract
Objective
To evaluate MRI features of sarcomatoid renal cell carcinoma (RCC) and their association with survival.

Methods
This retrospective single-center study included 59 patients with sarcomatoid RCC who underwent MRI before nephrectomy during July 2003–December 2019. Three radiologists reviewed MRI findings of tumor size, non-enhancing areas, lymphadenopathy, and volume (and percentage) of T2 low signal intensity areas (T2LIA). Clinicopathological factors of age, gender, ethnicity, baseline metastatic status, pathological details (subtype and extent of sarcomatoid differentiation), treatment type, and follow-up were extracted. Survival was estimated using Kaplan-Meier method and Cox proportional-hazards regression model was used to identify factors associated with survival.

Results
Forty-one males and eighteen females (median age 62 years; interquartile range 51–68) were included. T2LIAs were present in 43 (72.9%) patients. At univariate analysis, clinicopathological factors associated with shorter survival were: greater tumor size (> 10 cm; HR [hazard ratio] = 2.44, 95% CI 1.15–5.21; p = 0.02), metastatic lymph nodes (present; HR = 2.10, 95% CI 1.01–4.37; p = 0.04), extent of sarcomatoid differentiation (non-focal; HR = 3.30, 95% CI 1.55–7.01; p < 0.01), subtypes other than clear cell, papillary, or chromophobe (HR = 3.25, 95% CI 1.28–8.20; p = 0.01), and metastasis at baseline (HR = 5.04, 95% CI 2.40–10.59; p < 0.01). MRI features associated with shorter survival were: lymphadenopathy (HR = 2.24, 95% CI 1.16–4.71; p = 0.01) and volume of T2LIA (> 3.2 mL, HR = 4.22, 95% CI 1.92–9.29); p < 0.01). At multivariate analysis, metastatic disease (HR = 6.89, 95% CI 2.79–16.97; p < 0.01), other subtypes (HR = 9.50, 95% CI 2.81–32.13; p < 0.01), and greater volume of T2LIA (HR = 2.51, 95% CI 1.04–6.05; p = 0.04) remained independently associated with worse survival.

Conclusion
T2LIAs were present in approximately two thirds of sarcomatoid RCCs. Volume of T2LIA along with clinicopathological factors were associated with survival.
Synoptic meteorological conditions of gamma-ray glows in winter thunderstorms
Authors: Wada Yuuki , Tsurumi Miwa , Hayashi Syugo , Michimoto Koichiro 
Published: February 2023

AbstractThe Gamma-ray Observation of Winter Thunderclouds collaboration has detected 70 gamma-ray glows, a high-energy phenomenon associated with thunderstorms, from October 2016 to March 2020 in Kanazawa and Komatsu, Ishikawa Prefecture, a central part of Japan facing the Sea of Japan. Based on surface and 500 hPa analyses, numerical prediction models, and surface and satellite observations, we classify their synoptic meteorological conditions into mainly three types. Most of the glow-detection cases were in west or west-southwest winds around the detection sites. Over half of the cases took place when a convex structure of surface pressure, often associated with a trough at 500 hPa, was formed along the coast of the Sea of Japan. Besides, we extract non-detection cases during winter thunderstorms in Kanazawa to compare with the glow-detection cases. While some of the non-detection cases have similar meteorological conditions as the glow-detection cases, most of the non-detection cases exhibited higher temperatures at the surface and 850 hPa, and higher − 10 $$^{\circ }$$

∘

C altitudes, which indicates that electrification occurs at higher altitudes than the glow-detection cases. Therefore, gamma rays might have been produced but were attenuated before reaching the ground and undetectable at sea level.
Development of a novel moisture-suppression bag for the preservation of hygroscopic medications
Authors: Matsuo Taisuke , Yoshida Takayuki , Ushijima Kiyotaka , Doi Takashi , Sadzuka Yasuyuki , Tomita Takashi 
Published: February 2023

Abstract
Background
One-dose packaging is frequently used in Japan for elderly patients who are prescribed several medications. It is useful for easy administration and the prevention of misuse or missed medications. Hygroscopic medications are not suitable for one-dose packaging because moisture absorption may alter their properties. Plastic bags with desiccating agents are sometimes used to store hygroscopic medicines in one-dose packaging. However, the relationship between the quantity of desiccating agents and their safety in the storage of hygroscopic medications is poorly understood. Furthermore, older adults might accidentally consume desiccating agents used in food preservation. In this study, we developed a bag that suppresses the moisture absorption of hygroscopic medications without the use of desiccating agents.

Methods
The bag was manufactured using polyethylene terephthalate, polyethylene, and aluminum film on the outside, and unified with a desiccating film on the inside.

Results
The relative humidity (RH) in the bag was maintained at approximately 30–40% when the bag was stored at 75% RH and 35 °C. The manufactured bag’s moisture suppressing effect was better than that of plastic bags with desiccating agents when the hygroscopic medications, potassium aspartate and sodium valproate tablets, were stored at 75% RH and 35 °C for 4 weeks.

Conclusions
The moisture-suppression bag effectively stored and preserved hygroscopic medications and was more effective in inhibiting moisture absorption than plastic bags with desiccating agents under high temperature and humidity conditions. The moisture-suppression bags are expected to be useful for elderly patients who are prescribed several medications in one-dose packaging.
Dedifferentiated liposarcoma primary to the chest wall with spontaneous shrinking: report of a case
Authors: Itagaki Yuki , Fukunaga Akira , Takano Hironobu , Yamamoto Kazuyuki , Nishigami Kohei , Ichimura Tatsunosuke , Manase Hiroto , Obata Masahiko , Kato Tatsuya , Hirano Satoshi 
Published: February 2023

AbstractAn 80-year-old man presented to our emergency department complaining of a mass on the right side of his chest and pain in the right flank of his back. A chest computed tomography (CT) scan showed a relatively heterogenous oval-shaped tumor measuring 7.5 × 6.0 cm eroded to the 8th rib, with slightly dense fluid accumulation inside and calcification of the tumor wall. A 1-month follow-up CT scan showed spontaneous shrinkage of the tumor. The tumor was completely excised from the thoracic wall and the wall was reconstructed with a polytetrafluoroethylene mesh. Pathological examination showed coagulation necrosis in the chest wall tumor, but immunohistochemical staining revealed murine double minute 2- and Cyclin-dependent kinase 4-positive cells with irregular nuclear size and bizarre morphology. Therefore, dedifferentiated liposarcoma (DDLPS) was the final pathological diagnosis. Remarkable infiltration of CD8+ lymphocytes into the tumor was observed, along with a 90% positive ratio for programmed cell death-ligand 1. The patient has been followed-up for 1 year without any recurrence, despite not receiving any additional treatment. Liposarcoma is one of the most common types of soft tissue sarcomas; however, spontaneous regression of primary DDLPS arising from the chest wall is extremely rare. Herein, we report a case of DDLPS primary to the chest wall with spontaneous regression, probably due to a spontaneously induced T cell response.
Design models for small run-of-river hydropower plants: a review
Authors: Tsuanyo David , Amougou Boris , Aziz Abdoul , Nka Nnomo Bernadette , Fioriti Davide , Kenfack Joseph 
Published: February 2023

AbstractHydropower plants are among the most efficient and reliable renewable energy systems in the world as far as electricity production is concerned. Run-of-river hydropower plants seem more attractive than conventional hydroelectric plants since they can be a cheaper and environmentally friendly alternative. However, their expected energy production pattern heavily depends on several construction variables that need an appropriate design using specific models. This paper analyzes several existing models used for the calculation of the diameter and thickness of a penstock, the optimal selection and implantation (admissible suction head) of a turbine, to estimate the energy produced and expected cost of small hydropower projects for grid-connected and off-grid/micro-grid applications. This review particularly brings out the specificities of each of the models to suggest the most appropriate model according to the context of study and proposes methods to use them more efficiently. This review can be used as a guide in the design and simulation of run-of-river hydropower plants, thus helping in the assessment of the economic feasibility of projects that usually requires a high level of experience and expertise.
Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link
Authors: Awasthi Richa , Manger Priyanka Thapa , Khare Rajesh Kumar 
Published: February 2023

AbstractThe vitamin D receptor (VDR) gene serves as a good candidate gene for susceptibility to essential hypertension. The gene regulates the renin angiotensin system by influencing blood pressure regulation. Around 3% of the human genome is regulated by the vitamin D endocrine system. Several studies have reported mixed results with respect to relationship of VDR gene and hypertension. Observational evidence supports the concept that vitamin D plays a role in the pathogenesis of cardiovascular disease and arterial hypertension which is further supported by meta-analysis and case control studies reporting how VDR polymorphism leads to the onset and development of hypertension. In this review, we summarize the existing literature on the link between VDR and hypertension, including mechanistic studies, observational data, and clinical trials showing relationship of vitamin D level and hypertension with a focus on recent findings related to genetic studies that showed the relationship of VDR gene polymorphism with vitamin D level in hypertensive and normotensive groups. As a result, determining the association of VDR polymorphisms with essential hypertension is expected to aid in the risk assessment for the condition.
Challenges of CSR in Sub-Saharan Africa: clarifying the gaps between the regulations and human rights issues
Authors: Ndong Ntoutoume Achille Gildas 
Published: February 2023

AbstractThis paper discusses the practice of Corporate Social Responsibility (CSR) and its challenges in Sub-Saharan Africa. The main purpose is to highlight and clarify the gaps between CSR regulations and human rights abuses caused by business organizations.From a historical perspective, natural resources have been recognized as a common reason for pushing the CSR agenda in Sub-Saharan Africa, especially with the presence of big businesses in the outcome of globalization. However, despite a development-oriented CSR agenda and therefore on African local needs such as hospitals, housing, and roads, big businesses that have embarked on CSR activities are often involved in human rights violations. This is despite the insertion of human rights in some African state regulations, the UN Global Compact, and the UN Guiding Principles on Business and Human Rights in which those businesses are signatories. This is the case in Gabon, Nigeria, and South Africa whose regulations were established by the respective states indicate business’ broader societal priorities directed towards stakeholders (local communities in particular) but in terms of corporate obligations, ‘Human Rights appear to be a blind spot in CSR’.The reasons for that are indicated in the findings of this qualitative inquiry, which reveals deep problems of corporate governance and little understanding of corporate human rights in domestic legislation. According to international law, human rights fulfillment focuses on nation-states as sole bearers. This means other non-state actors have indirect human rights responsibilities. Therefore, the challenge remains to extend and interpret existing domestic and international frameworks to include CSR alongside traditional state obligations. This could make corporate human rights more ‘applicable’ to businesses.Previous research by Visser and Amodu has focused on proposing models to respond to the challenges of CSR in Africa. This paper clarifies the challenges of CSR with human rights issues and suggests an extension of the current legislative framework covering CSR. The article is qualitative and has used a Desk Research study approach that includes published academic papers, government documents some secondary data such as case studies, interviews, and discussions.
Validity and reliability of the Chinese version of Threats of Artificial Intelligence Scale (TAI) in Chinese adults
Authors: Cai Jie , Xu Zixuan , Sun Xiaoning , Guo Xiaojun , Fu Xurong 
Published: February 2023

AbstractWith the outbreak of the COVID-19 pandemic, artificial intelligence (AI) has been widely used in fields such as medical treatment, while the threat of artificial intelligence has also received extensive attention. However, this topic has been only limitedly explored in China. To provide a measurement tool for AI threat research in China, this study aimed to examine the validity and reliability of the Threats of Artificial Intelligence Scale (TAI) in two Chinese samples of adults (N1 = 654, N2 = 1483). Results of exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) suggested that the one-factor model of TAI as the best fitting model. Furthermore, the Chinese TAI was significantly related to Positive and Negative Affect Scale and Self-Rating Anxiety Scale, proving good criterion-related validity of the Chinese TAI. In sum, this study suggested the Chinese version of the TAI as a reliable and effective tool in assessing AI threat in the Chinese context. Limitations and future directions are discussed.
Epilepsy-associated open-lip schizencephaly with arachnoid cyst: a rare case report
Authors: Hapsari Patricia , Celia  , Nagpal Chand , Andre  , Ronny  , Shen Robert 
Published: February 2023

Abstract
Background
Schizencephaly is a rare congenital cerebral malformation characterized by clefts in the cerebral cortex. The traction effect and splitting of leptomeninges caused by schizencephaly potentially formed an arachnoid cyst.

Case presentation
We present a case of an 18-year-old male with history of several episodes of complex partial seizure over the last 2 months, with an electroencephalogram signified an epileptic form in the right temporal lobe. Brain magnetic-resonance imaging revealed an arachnoid cyst in the right temporal fossa and a grey matter-lined right temporal cleft consistent with open-lip schizencephaly. To the best of authors’ knowledge, only two previous similar cases have been reported in 1997. Our patient underwent cystoperitoneal shunt and was given double anti-epileptic agents, which successfully resolved and prevented the seizure episode during further follow-up.

Conclusion
New onset of seizure-associated schizencephaly in adult are very rare. In this case, space-occupying lesions effects from the enlarged arachnoid cysts caused seizure, which resolved after the cystoperitoneal shunt and double anti-epileptic agents.
A technical review of bail-out procedures to place Najuta stent-graft into the ascending aorta
Authors: Berchiolli Raffaella , Troisi Nicola , Bertagna Giulia , Colli Andrea , Besola Laura , Silingardi Roberto , Simonte Gioele , Isernia Giacomo ,   Italian Najuta registry collaborators, Orrico Matteo , Lenti Massimo , Parlani Gianbattista , Fino Gianluigi , Covic Tea , Gennai Stefano , Ferri Michelangelo , Ferrero Emanuele , Quaglino Simone , Rizza Antonio , Maritati Gabriele , Portoghese Michele , Verzini Fabio , Discalzi Andrea , Pulli Raffaele , Fargion Aaron , Bonvini Stefano , Intrieri Francesco , Speziale Francesco , Mansour Wassim , Moniaci Diego , Troisi Nicola , Colli Andrea , Camparini Stefano , Genavi Genadiev , Pratesi Giovanni , Massi Francesco , Michelagnoli Stefano , Chisci Emiliano , Bonardelli Stefano , Maione Massimo , Angiletta Domenico , Zacà Sergio , Veraldi Gian Franco , Mezzetto Luca 
Published: February 2023

Abstract
Background
The Najuta stent-graft (Kawasumi Laboratories Inc., Tokyo, Japan) is usually easily advanced to the correct deployment position in the ascending aorta thanks to the pre-curved delivery J-sheath with all fenestrations automatically oriented towards the supra-aortic vessels. Aortic arch anatomy and delivery system stiffness could however represent limitations for proper endograft advancement, especially when the aortic arch bends sharply. The aim of this technical note is to report a series of bail-out procedures that could be useful to overcome the difficulties encountered during the Najuta stent-graft advancement up to the ascending aorta.

Main body
The insertion, positioning and deployment of a Najuta stent-graft requires a through-and-through guidewire technique using a .035″ 400 cm hydrophilic nitinol guidewire (Radifocus™ Guidewire M Non-Vascular, Terumo Corporation, Tokyo, Japan) with right brachial and both femoral accesses. When standard maneuver to put the endograft tip into the aortic arch, some bail-out procedures can be applied to obtain proper positioning. Five techniques are described into the text: positioning of a coaxial extra-stiff guidewire; positioning of a long introducer sheath down to the aortic root from the right brachial access; inflation of a balloon inside the ostia of the supra-aortic vessels; inflation of a balloon inside the aortic arch (coaxial to the device); and transapical access technique. This is a troubleshooting guide for allowing physicians to overcome various difficulties with the Najuta endograft as well as for other similar devices.

Short conclusion
Technical issues in advancing the delivery system of Najuta stent-graft could occur. Therefore, the rescue procedures described in this technical note could be useful to guarantee the correct positioning and deployment of the stent-graft.
Spontaneous antenatal uterine rupture in a primiparous patient with placenta praevia: Does previous laparoscopic treatment of endometriosis increase the risk?
Authors: Datta Sujata , Basu Ritisha 
Published: February 2023

Abstract
Background
Unprovoked spontaneous uterine rupture in a primigravid unscarred uterus is a rare but serious obstetric complication. Our case highlights a prelabour uterine rupture in a primiparous patient with an anterior placenta praevia and transverse lie at 32 weeks.

Case presentation
The patient presented with severe continuous abdominal pain and an abnormal Cardiotocograph antenatally. An emergency Caesarean section done with suspicion of concealed abruption revealed a cornual uterine rupture with 2 L of hemoperitoneum.

Conclusion
The patient and her baby recovered well from surgery, thus, emphasizing the necessity of timely intervention. An association with previous laparoscopic treatment of severe endometriosis and adenomyosis is explored.
3′ UTR is critical for viral RNA accumulation of jasmine virus H
Authors: Zhu Li-Juan , Zhang Chong-Tao , Bai Ya-Ni , Jiang Chao-Yang , He Shi-Yun , Chang Qing , Xu Qian , Han Yan-Hong 
Published: February 2023

AbstractJasmine virus H (JaVH) is a newly reported viral pathogen of jasmine in China and USA. To study the viral gene function and pathogenic mechanism, a full-length infectious clone of JaVH (pXT-JaVHFJ) was constructed under the control of the cauliflower mosaic virus 35S promoter. pXT-JaVHFJ induced a systemic infection in Nicotiana benthamiana plants by Agro-infiltration, which demonstrated that pXT-JaVHFJ was biologically active. Jasmine showed yellow spots after rubbing with total RNA extracted from Agro-infiltrated N. benthamiana, indicating that JaVH was highly associated with yellow mosaic symptoms observed on jasmine. To investigate the occurrence and mutations of the virus, jasmine samples were collected from eight provinces of China and were tested for JaVH. The samples that were tested positive for JaVH were used to determine the complete genome sequences. They were comprised of 3867 or 3868 nucleotides and their genome organizations resembled that we previous reported for JaVH-FJ. Phylogenetic analyses and sequence comparisons suggest that the eight virus isolates were close isolates of JaVH-FJ and the isolate from Jilin Province was most closely related to JaVH-FJ with 99.2% nucleotide identity over the entire genome and 99.7% identity of coat protein. Further comparative analyses of JaVH-FJ and JaVH-JL revealed additional nucleotide differences in the 3′-untranslated region (3′ UTR). An infectious clone of JaVH-JL and chimeric mutants containing JaVH-FJ or JaVH-JL 3′ UTRs were then constructed for further study. The differential accumulation of JaVH with distinct 3′ UTR suggested that the 3′ UTR of JaVH plays a crucial role in viral RNA accumulation.