bluuebunny/crossref_metadata_2025_split huggingface dataset:
Вплив медіа на формування довіри громадян до влади в період війни
Authors: Міщенко Алла , Теремко Віктор 
Published: June 2023

Стаття присвячена виявленню вирішальних змін в інформаційному просторі України після початку повномасштабної агресивної війни Росії проти України та визначенню впливу медіа на формування довіри суспільства до влади у вказаний період. Для досягнення поставленої мети використано міждисциплінарний підхід і поєднання дослідницьких інформаційних джерел та методів різних наукових напрямів, зокрема журналістики, соціальних комунікацій, соціології, політичної науки тощо. У статті розкрито основні форми обмеження інформаційного простору, які відбулися в телевізійному форматі та друкованих виданнях. Водночас значного зростання в поширенні суспільно важливих повідомлень отримали такі платформи, як Facebook, YouTube, Telegram, Tiktok, які не були цензуровані владою та поширювали інформацію від першоджерел про поточні події, особливо в зонах бойових дій.
Дослідження довело, що засоби масової інформації залишаються основним інструментом посилення вертикальної взаємодії між владою та суспільством, що дозволяє соціально-політичним інститутам легітимізувати власну діяльність та державні рішення. Складання порівняльної таблиці та висвітлення діаграм соціологічних досліджень рівня довіри громадян до влади виявило тенденцію значного зростання підтримки інституцій влади з боку суспільства в середньостатистичній динаміці 25 відсотків, що значно відрізняється від показників попередніх років незалежності України. Відповідно, владі вдалося сформувати суспільну підтримку не тільки своїх дій в період війни, а й укорінити усвідомлення суспільством важливості монопольного управління державою у визначальних сферах, зокрема безпековій.
مدارس سيمياء السرد
Authors: الجبوري حنان , جابر يوسف 
Published: June 2023

امتازت سيمياء السرد بظهور عدد من المدارس التطبيقية، ولكل مدرسة من هذه المدارس رؤيتها ومكانتها في النقد المعاصر، وتفرعت عنها مجموعة من المناهج والاتجاهات.
يعرض البحث لأبرز مدارس سيمياء السرد، وهي مدرسة تارتو- موسكو، والمدرسة الإيطالية (سيميوطيقيا الثقافة)، ومدرسة باريس (سيمياء السرد) أو سيمياء الدلالة وأبرز منظريها غريماس. وسيناقش البحث منهجية كل مدرسة وعلاقتها مع المدارس الأخرى.
FIRE RESISTANCE DESIGN ANALYSIS FOR STEEL CONNECTIONS USING SPECIALIZED 3D MODELING SOFTWARE
Authors: HITSKOV Kristian , LAVRINENKO Liudmyla 
Published: June 2023

The work presents the design process, analysis and practical evaluation of nodal connections of the beam-column frame of a low-rise building in the BIM design environment for the action of active loads and emergency temperature effects of fire. A study of the use of design tools was conducted. The conduct of such studies is due to the need to increase the reliability of the steel frame in fire conditions and to update the requirements of the normative documents of the Eurocodes regardingthe fire resistance of metal structures. The standard fire mode was considered, the heating parameters ofelements connected in nodes were analyzed. A review of the theoretical foundations of the calculation of steel structures for the high-temperature effect of the working environment showed the feasibility of applying a simplified method of calculation and determination of heating parameters accordingto normative data.Simulated rod diagram of the frame with loads. An analysis of the stress-strain behavior (SSB) ofthe elements under the action of the emergency combination was carried out. 3D modeling of thenode was used for further calculation. The BIM concept is implemented by integrating Robot StructuralAnalysis PC with the IdeaStatica calculation complex. It has been established that the connection ofPC Robot Structural Analysis with the IdeaStatica calculation complex is rational for the design andcalculations of buildings and structures in 3D space and allows using the results of the temperature effect calculation to adjust the structural solution in order to reduce its metal consumption, labor costsand rationalize the reserves of bearing capacity.The presented process of designing frame nodes summarizes approaches to the development of effective structural forms. The use of information models simplified design, optimized work processes, and also made it possible to increase the complexity of nodes both at the level of the designsolution and at the level of the calculation model, taking into account the nonlinear effects of temperature influence.
Dose-dense neoadjuvant chemotherapy of operable and locally advanced inoperable triple negative breast cancer: First results of single-centre prospective trial
Authors: Kovalenko E. I. , Zhulikov Ya. A. , Artamonova E. V. , Khoroshilov M. V. , Petrovskiy A. V. , Denchik D. A. , Drujinina D. I. , Vorotnikov I. K. 
Published: June 2023

Introduction. Neoadjuvant chemotherapy (NACT) is the standard of care for II–III stages of TN BC. Complete pathomorphological response (pCR) is associated with a signifiant increase in event-free and overall survival. In addition, in the absence of pCR, post-neoadjuvant adjuvant therapy is prescribed, while if pCR is achieved, additional treatment is not carried out. Despite a large number of studies on NACT of TN BC, different NACT regimens in various clinical trials make it diffiult to interpret their results.Objective. To investigate the effiacy of 4ddAC followed by 12 weekly cycles of paclitaxel and carboplatin in TN BC (according to the RCB system and the frequency of pCR); determine the predictive factors for the effectiveness of this chemotherapy regimen, and the effect of dose intensity on the pCR rate.Methods. This prospective study included 154 patients with TN breast cancer who received dose-dence neoadjuvant chemotherapy from January 2017 to March 2022.Results. PCR rate was 53.25 % (n = 82), RCB 0–I was 66.88 % (n = 103), disease progression was observed in 3.25 % (n = 4). The frequency of germline mutations in the BRCA1/2 genes was 21.43 % (n = 33). The most common mutation was BRCA1 5382insC – 63.64 % (n = 21) of all BRCA1/2 mutations. Rare mutations detected by NGS accounted for 30.3 % (n = 10). The only factor associated with a signifiant increase in the pCR rate was age ≤50 years (p = 0.010), there was a trend towards an increase pCR rate in the subgroups T1–2 (p = 0.052) and BRCA1/2 mut (p = 0.080). There was no effect of the dose intensity on the achievement of pCR.Conclusions. This retrospective analysis is the largest study evaluating the effiacy of 4 ddAC followed by 12 PC in NACT TN BC. The regimen allows to achieve a high frequency of pCR, despite the large proportion of patients with locally advanced breast cancer. The high frequency of rare mutations in the BRCA1/2 genes and the potential therapeutic signifiance of this marker in residual disease treatment dictates the need for NGS in all patients with TN in breast cancer.
Electroencephlographic predictors of epileptiphorm activity in children with lymphoid tumors under therapy
Authors: Kuznetsova E. I. , Gorbachevskaya N. L. 
Published: June 2023

Objective. To identify electroencephalographic predictors of symptomatic seizure in children and adolescent with lymphoid tumors during chemotherapy.Material and methods. EEG results of a study in 20 children aged 7 to 15 years with lymphoid tumors during chemotherapy under the В-NHLBFM-90/95 и ALL IC-BFM 2002 program are presented. Depending on the presence of clinical manifestations, patients were divided into groups: 1st group (n = 10 without epileptiform signs), 2nd group (n = 10 with epileptiform signs).Results. In patients of group 1, who did not have clinical manifestations (seizures), the EEG recorded a signifiantly better, compared with patients of group 2, spectral dencity in band alpha rhythm and sensorimotor rhythm (p < 0.001) and signifiantly less delta activity and beta frequencies (p < 0.001). It was found that, despite the absence of epileptiform signs in the EEG, these patients had fewer EEG correlates of the ‘spike-wave’ complexes, and signifiantly less power levels of delta and beta-2 frequency bands (p < 0.001).Conclusions. The use of comparative EEG mapping made it possible to identify predictors of epileptiform activity in children and adolescents with lymphoid tumors during chemotherapy.
Possibilities of using contrast-enhanced ultrasound to assess intracavitary lesions in renal cysts
Authors: Mitina L. A. , Stepanov S. O. 
Published: June 2023

Objective. Determination of the diagnostic signifiance of the use of a contrast agent during ultrasound, as well as to assess the possibility of using CEUS for the dynamic observation of simple and complex kidney cysts.Materials and methods. Between 2018 and 2020 during CEUS, we examined 28 patients with various cystic formations of the kidneys. In the majority of patients with simple cysts, CEUS was performed for another underlying cancer or to confim the presence of liver metastases. The study included cysts ranging in size from 15 to 35 mm. Larger cysts were weeded out. The accumulation of contrast in the unchanged kidney tissue and in the walls of the cysts was assessed. Particular attention was paid to the partitions in the lumen of anechoic formations, as well as complex cysts, in which blood flw appeared in the altered partitions and walls in the arterial phase.Conclusions. CEUS can be performed as an additional method when obtaining doubtful results or as a diagnosis during dynamic monitoring for the detection of kidney cysts. CEUS allows the detection of membranes in kidney cysts that are not detected by ultrasound in the standard mode.The technique also helps to effectively differentiate absorption between a solid formation and a normal cyst. According to the accumulation of the contrast agent in the cysts, patients can be divided into categories, according to the classifiation of M. A. Bosnian and make a decision on the need for surgical treatment or placing the patient under dynamic observation.
Don't forget about customer magazines: the effects of reading experiences on customer magazine effectiveness
Authors: Koob Clemens 
Published: June 2023

IntroductionContent marketing continues to gain importance in organizations' marketing mix. However, its effectiveness has received little academic attention. This is particularly true of customer magazines, which, despite increasing digitization, remain a key pillar of content marketing and account for considerable investments. Therefore, this paper examines how reading experiences affect the effectiveness of customer magazines, mediated by media engagement.MethodsBased on the uses-and-gratifications-theory and literature on sensory perception, journalistic quality, and media engagement, several hypotheses are proposed. To investigate the hypotheses, the study uses a cross-sectional survey. The dataset for the analyses consists of 1,396 consumers and is analyzed by structural equation modeling.ResultsThe results indicate that hedonically gratifying, as well as identity-enforcing content experiences and visually and haptically gratifying process experiences are associated with higher effectiveness. Media engagement mediates these effects. Experienced journalistic quality directly and positively influences customer magazine effectiveness.DiscussionThis study's findings are important to marketing communications research. In particular, the study contributes to the still limited literature on content marketing effectiveness and helps practitioners optimize customer magazines.
Association between serum albumin-to-creatinine ratio and clinical outcomes among patients with ST-elevation myocardial infarction after percutaneous coronary intervention: a secondary analysis based on Dryad databases
Authors: Huang Xiaoye , Liu Yuchun , Zhong Chuyang , Lin Zengrui , Zheng Binyun 
Published: June 2023

BackgroundThe prognostic value of the serum albumin-to-creatinine ratio (sACR) in patients with ST-elevation myocardial infarction (STEMI) remains unclear. This study aims to investigate the impact of the sACR on incident major adverse cardiovascular events (MACEs) among revascularized patients with STEMI at long-term follow-up.MethodsA total of 461 patients with STEMI who underwent successful primary percutaneous coronary intervention (PCI) were enrolled to explore the association between the sACR and MACE during a 30-month follow-up. The Cox regression proportional hazard model was used to evaluate the prognostic value of the sACR. Heterogeneity among specific groups was investigated by subgroup analysis.ResultsA total of 118 patients developed MACE during the follow-up. A negative association between the sACR and MACE was found after adjusting for other MACE-related risk factors. In subgroup analyses, the sACR was inversely associated with MACE in patients aged ≥ 60 years [hazard ratio (HR), 0.478; 95% confidence interval (CI), 0.292–0.784], male (HR, 0.528; 95% CI, 0.327–0.851), with hypertension history (HR, 0.470; 95% CI, 0.271–0.816), and with anterior wall myocardial infarction (HR, 0.418; 95% CI, 0.239–0.730). Meanwhile, the negative association between the sACR and MACE remained significant in a sensitivity analysis that excluded patients with low serum albumin levels (HR, 0.553; 95% CI, 0.356–0.860).ConclusionsPatients with STEMI who underwent successful PCI with a low sACR had a higher risk of developing MACE, indicating that the sACR could be used to identify patients with STEMI who are at high risk of developing MACE.
Mitochondrial depletion syndrome type 3: the Lebanese variant
Authors: Majdalani Marianne , Yazbeck Nadine , El Harake Lamis , Samaha Jinane , Karam Pascale E. 
Published: June 2023

Introduction: Mitochondrial DNA depletion syndrome type 3 is an emerging disorder linked to variants in the deoxyguanosine kinase gene, which encodes for mitochondrial maintenance. This autosomal recessive disorder is frequent in the Middle East and North Africa. Diagnosis is often delayed due to the non-specificity of clinical presentation with cerebro-hepatic deterioration. The only therapeutic option is liver transplantation, although the value of this remains debatable.Methods: We describe the clinical, biochemical, and molecular profiles of Lebanese patients with this rare disorder. We also present a review of all cases from the Middle East and North Africa.Results: All Lebanese patients share a unique mutation, unreported in other populations. Almost half of patients worldwide originate from the Middle East and North Africa, with cases reported from only 7 of the 21 countries in this region. Clinical presentation is heterogeneous, with early-onset neurological and hepatic signs. Liver failure and lactic acidosis are constants. Several variants can be identified in each population; a unique c.235C&gt;T p. (Gln79*) pathogenic variant is found in Lebanese patients. Outcome is poor, with death before 1 year of age.Conclusion: The pathogenic nonsense variant c.235C&gt;T p. (Gln79*) in the deoxyguanosine kinase gene may be considered a founder mutation in Lebanon. Further genotypic delineation of this devastating disorder in populations with high consanguinity rates is needed.
The correlation between modifications to corneal topography and changes in retinal vascular density and retinal thickness in myopic children after undergoing orthokeratology
Authors: Lian Yan , Lu Weiwei , Xu Aiqin , Chen Renai , Lu Qingqing , Zhou Weihe , Mei Lili , Jin Wanqing 
Published: June 2023

PurposeThis study aimed to investigate the relationship among changes in corneal topography, retinal vascular density, and retinal thickness in myopic children who underwent orthokeratology for 3 months.MethodThirty children with myopia wore orthokeratology lenses for 3 months. Using optical coherence tomography angiography (OCTA), the retina was imaged as 6 × 6 mm en-face images at baseline and 3 months after orthokeratology. Cornea data was acquired by topography and analyzed by customer MATLAB software. The cornea was divided into 3 zones and 9 sectors. The relative corneal refractive power shift (RCRPS) was used in this study. Changes in retinal vascular density (RVDC) and retinal thickness change (RTC) were associated with RCRPS by using spearman test. Statistical significance was set at p &lt; 0.05.ResultA significant correlation was observed between the RVDC and the RCRPS in many regions (the r was 0.375 ~ 0.548, all p value &lt;0.05). Significant positive correlations were found between RVDC in inner and outer temple regions with RCRPS at inner and outer nasal sectors. There were no significant correlations between RTC and RCRPS in other sectors except in the central cornea and the outer nasal retina (r:0.501, p:0.006). At baseline and 3 months after wearing the orthokeratology lens, no significant differences in the retinal microvasculature or thickness (p &gt; 0.05) were observed at any regions.ConclusionThe correlation between the cornea and the retina was observed after orthokeratology. Cornea changes may affect regional retinal responses accordingly，which may explain how orthokeratology delays myopia progression partially.
Exploring potential biomarkers and therapeutic targets of long COVID-associated inflammatory cardiomyopathy
Authors: Qi Peng , Huang Mengjie , Zhu Haiyan 
Published: June 2023

BackgroundThe negative impact of long COVID on social life and human health is increasingly prominent, and the elevated risk of cardiovascular disease in patients recovering from COVID-19 has also been fully confirmed. However, the pathogenesis of long COVID-related inflammatory cardiomyopathy is still unclear. Here, we explore potential biomarkers and therapeutic targets of long COVID-associated inflammatory cardiomyopathy.MethodsDatasets that met the study requirements were identified in Gene Expression Omnibus (GEO), and differentially expressed genes (DEGs) were obtained by the algorithm. Then, functional enrichment analysis was performed to explore the basic molecular mechanisms and biological processes associated with DEGs. A protein–protein interaction (PPI) network was constructed and analyzed to identify hub genes among the common DEGs. Finally, a third dataset was introduced for validation.ResultsUltimately, 3,098 upregulated DEGs and 1965 downregulated DEGs were extracted from the inflammatory cardiomyopathy dataset. A total of 89 upregulated DEGs and 217 downregulated DEGs were extracted from the dataset of convalescent COVID patients. Enrichment analysis and construction of the PPI network confirmed VEGFA, FOXO1, CXCR4, and SMAD4 as upregulated hub genes and KRAS and TXN as downregulated hub genes. The separate dataset of patients with COVID-19 infection used for verification led to speculation that long COVID-associated inflammatory cardiomyopathy is mainly attributable to the immune-mediated response and inflammation rather than to direct infection of cells by the virus.ConclusionScreening of potential biomarkers and therapeutic targets sheds new light on the pathogenesis of long COVID-associated inflammatory cardiomyopathy as well as potential therapeutic approaches. Further clinical studies are needed to explore these possibilities in light of the increasingly severe negative impacts of long COVID.
Whole genome analysis and antimicrobial resistance of Neisseria gonorrhoeae isolates from Ghana
Authors: Agbodzi Bright , Duodu Samuel , Dela Helena , Kumordjie Selassie , Yeboah Clara , Behene Eric , Ocansey Karen , Yanney Jennifer N. , Boateng-Sarfo George , Kwofie Samuel Kojo , Egyir Beverly , Colston Sophie M. , Miranda Hugo V. , Watters Chaselynn , Sanders Terrel , Fox Anne T. , Letizia Andrew G. , Wiley Michael R. , Attram Naiki 
Published: June 2023

IntroductionGonorrhoea is a major public health concern. With the global emergence and spread of resistance to last-line antibiotic treatment options, gonorrhoea threatens to be untreatable in the future. Therefore, this study performed whole genome characterization of Neisseria gonorrhoeae collected in Ghana to identify lineages of circulating strains as well as their phenotypic and genotypic antimicrobial resistance (AMR) profiles.MethodsWhole genome sequencing (WGS) was performed on 56 isolates using both the Oxford Nanopore MinION and Illumina MiSeq sequencing platforms. The Comprehensive Antimicrobial Resistance Database (CARD) and PUBMLST.org/neisseria databases were used to catalogue chromosomal and plasmid genes implicated in AMR. The core genome multi-locus sequence typing (cgMLST) approach was used for comparative genomics analysis.Results and DiscussionIn vitro resistance measured by the E-test method revealed 100%, 91.0% and 85.7% resistance to tetracycline, penicillin and ciprofloxacin, respectively. A total of 22 sequence types (STs) were identified by multilocus sequence typing (MLST), with ST-14422 (n = 10), ST-1927 (n = 8) and ST-11210 (n = 7) being the most prevalent. Six novel STs were also identified (ST-15634, 15636-15639 and 15641). All isolates harboured chromosomal AMR determinants that confer resistance to beta-lactam antimicrobials and tetracycline. A single cefixime-resistant strain, that belongs to N. gonorrhoeae multiantigen sequence type (NG-MAST) ST1407, a type associated with widespread cephalosporin resistance was identified. Neisseria gonorrhoeae Sequence Typing for Antimicrobial Resistance (NG-STAR), identified 29 unique sequence types, with ST-464 (n = 8) and the novel ST-3366 (n = 8) being the most prevalent. Notably, 20 of the 29 STs were novel, indicative of the unique nature of molecular AMR determinants in the Ghanaian strains. Plasmids were highly prevalent: pTetM and pblaTEM were found in 96% and 92% of isolates, respectively. The TEM-135 allele, which is an amino acid change away from producing a stable extended-spectrum β-lactamase that could result in complete cephalosporin resistance, was identified in 28.5% of the isolates. Using WGS, we characterized N. gonorrhoeae strains from Ghana, giving a snapshot of the current state of gonococcal AMR in the country and highlighting the need for constant genomic surveillance.
The efficacy of community-based exercise programs on circulating irisin level, muscle strength, cardiorespiratory endurance, and body composition for ischemic stroke: a randomized controlled trial
Authors: Kang Dongheon , Park Jiyoung , Eun Seon-Deok 
Published: June 2023

ObjectiveWe investigated the changes in circulating irisin levels after community-based exercise and the association of these levels with improvements in muscle strength, cardiorespiratory endurance, and body composition in people with ischemic stroke.MethodsTwenty participants were randomly assigned to either a control or an exercise group. The community-based exercise program (CEP) consisted of 8 weeks of 1 h sessions for 3 days a week. Irisin levels, muscle strength, cardiorespiratory endurance, and body composition were assessed before and after the intervention.ResultsSignificant improvements were observed in the leg and trunk strength, peak oxygen consumption values, and body composition of the exercise group compared with the control group. In addition, circulating irisin levels were observed to have increased in the exercise group, positively correlated with muscle strength and cardiorespiratory endurance.ConclusionCEP might be an effective intervention to increase irisin levels and prevent a stroke-related decline in muscle function.