bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifunctional Self‐Assembled Ionic Liquid Modified Rigid and Flexible Substrates for Efficient Simple‐Structured Perovskite Solar Cells
Authors: Huang Shuai , Dong Guifang , Zhu Liangliang , Guan Baolu 
Published: August 2023

AbstractThe advancement of electron transport layer (ETL)‐free perovskite solar cells (PSCs) is crucial for the commercialization of PSCs. At present, the slow electron extraction and significant carrier recombination, related to the energy‐level alignment at the FTO/perovskite interface, restrict the performance of ETL‐free PSCs. The facile modification of bottom electrodes is pivotal for tackling these issues and stimulating the photovoltaic potential of perovskite. Herein, a cost‐competitive and neoteric 1‐hydroxyethyl‐3‐methylimidazolium chloride, [HOEtMIM]Cl, ionic liquid is employed to modify the surface of rigid and flexible electrodes, and thus enable an energetically well‐aligned interface with perovskite layer via the electric dipole effects. The resulting barrier‐free FTO/perovskite contact can tremendously ameliorate the electron extraction and collection, with mitigated nonradiative interfacial carrier recombination loss. Additionally, the lone pair on the nitrogen of the imidazole group passivates the surface defects of perovskite layers, and the chloride anion plays a role in the crystallinity improvement of perovskite. Leveraged by the [HOEtMIM]Cl modification, the resulting ETL‐free rigid and flexible devices deliver an outstanding power conversion efficiency of 19.60 % and 15.57 %, along with the ameliorated hysteresis and long‐term tenability. This finding highlights the drastic potential of the engineered [HOEtMIM]Cl in manufacturing stable and high‐performance ETL‐free PSCs for their scaled‐up production.
The potential molecularly therapy target to MYCN‐amplificated neuroblastoma
Authors: Jiang Susu , Zhang Xinxin , Chang Jiaming , Zhu Jinhong , Yang Wenhan , He Jing 
Published: August 2023

AbstractNeuroblastoma (NB) is an embryonal deadly cancer in childhood driven by MYC or MYCN‐driven oncogenic signaling. The amplification of MYCN leads to malignant progression of NB and poor prognosis. Traditional chemotherapy is still a standard treatment for NB. Most of the cytostatic drugs take function in anti‐neuroblastoma. However, children with NB exhibit different clinical outcome variability and biological characteristics compared to adult patients. Given this, it is an urgent need to explore novel, safer and more efficacious treatments.
A case of incorrect evaluation of intestinal patency by early dissolution of a patency capsule
Authors: Omori Teppei , Hara Toshifumi , Murasugi Shun , Kambayashi Harutaka , Sasaki Yu , Koroku Miki , Yonezawa Maria , Morishita Keiichi , Nakamura Shinichi , Tokushige Katsutoshi 
Published: August 2023

AbstractA 60‐year‐old man presented with a suspected small intestinal tumor on positron‐emission tomography‐computed tomography. Small bowel capsule endoscopy (SBCE) was planned for close examination of the small intestine. To avoid retention of the SBCE due to strictures, a patency capsule (PC) was first used to evaluate patency. However, PC discharge was not visually confirmed during the 24‐h period. No obvious PC was observed on plain abdominal radiography performed in the standing position. The patient underwent SBCE, assuming that the PC had been shed inconspicuously. SBCE revealed a neoplastic lesion with stenosis at a site thought to be the upper small intestine and remained stagnant at the same site for the duration of the battery. In addition, in the SBCE image, a PC shell was captured in the intestinal tract on the oral side of the stenosis. When the pre‐SBCE plain abdominal radiograph was enlarged to confirm the details, PC was observed in the lateral and decubitus views as a dissolved shell only. To the best of our knowledge, no previous report has described the complete dissolution of a PC leaving only its shell during a 30‐hour patency evaluation period. This case illustrates that, in the absence of visual confirmation of a PC discharge, PC may have remained in the body due to premature dissolution. Additional examinations or plain X‐ray imaging should be performed to confirm this, with no preconceived notions that the PC will not dissolve within 30 hours of administration.
Assessment of atmospheric solids analysis probe as a tool for the rapid determination of drug purity
Authors: Mathias Simone , Burns Daniel , Hambidge Tabatha , McCullough Bryan J. , Hopley Chris J. , Douce David , Sage Ashley , Sears Patrick 
Published: August 2023

AbstractThe ability to determine the purity (% controlled compound) of drug‐of‐abuse samples is necessary for public health and law enforcement. Here, we describe the assessment of atmospheric solids analysis probe (ASAP) for the rapid determination of drug purity for a set of formulated pharmaceuticals, chosen due to their availability, uncontrolled status and consistency. Paracetamol and loratadine were used as models of high and low purity compounds being ~90% and ~10% active ingredient, respectively. Individual tablets were ground up and diluted in an internal standard solution. The resulting samples were analysed by ASAP coupled to a Waters QDa mass spectrometer followed by confirmatory testing by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The inclusion of a non‐matched internal standard (quinine) improved linearity and repeatability of drug analysis by ASAP‐MS. Levels of drug purity using formulated pharmaceutical tablets were found to be highly comparable with results produced by the ‘gold standard’ LC–MS/MS technique. Rapid determination of drug purity is therefore possible with ASAP‐MS for highly concentrated samples with minimal sample preparation. It may be possible to use this deployable system to determine drug purity outside of a laboratory setting.
Larval density in the invasive Drosophila suzukii: Immediate and delayed effects on life‐history traits
Authors: Reyes‐Ramírez Alicia , Belgaidi Zaïnab , Gibert Patricia , Pommier Thomas , Siberchicot Aurélie , Mouton Laurence , Desouhant Emmanuel 
Published: August 2023

AbstractThe effects of density are key in determining population dynamics, since they can positively or negatively affect the fitness of individuals. These effects have great relevance for polyphagous insects for which immature stages develop within a single site of finite feeding resources. Drosophila suzukii is a crop pest that induces severe economic losses for agricultural production; however, little is known about the effects of density on its life‐history traits. In the present study, we (i) investigated the egg distribution resulting from females' egg‐laying strategy and (ii) tested the immediate (on immatures) and delayed (on adults) effects of larval density on emergence rate, development time, potential fecundity, and adult size. The density used varied in a range between 1 and 50 larvae. We showed that 44.27% of the blueberries used for the oviposition assay contained between 1 and 11 eggs in aggregates. The high experimental density (50 larvae) has no immediate effect in the emergence rate but has effect on larval developmental time. This trait was involved in a trade‐off with adult life‐history traits: The time of larval development was reduced as larval density increased, but smaller and less fertile females were produced. Our results clearly highlight the consequences of larval crowding on the juveniles and adults of this fly.
Identifying drivers of population dynamics for a stream breeding amphibian using time series of egg mass counts
Authors: Rose Jonathan P. , Kupferberg Sarah J. , Peek Ryan A. , Ashton Don , Bettaso James B. , Bobzien Steve , Bourque Ryan M. , Breedveld Koen G. H. , Catenazzi Alessandro , Drennan Joseph E. , Gonsolin Earl , Grefsrud Marcia , Herman Andrea E. , House Matthew R. , Kluber Matt R. , Lind Amy J. , Marlow Karla R. , Striegle Alan , van Hattem Michael , Wheeler Clara A. , Wilcox Jeffery T. , Wiseman Kevin D. , Halstead Brian J. 
Published: August 2023

AbstractThe decline in amphibian populations is one of the starkest examples of the biodiversity crisis. For stream breeding amphibians, alterations to natural flow regimes by dams, water diversions, and climate change have been implicated in declines and extirpations. Identifying drivers of amphibian declines requires long time series of abundance data because amphibian populations can exhibit high natural variability. Multiple population viability analysis (MPVA) models integrate abundance data and share information from different populations to estimate how environmental factors influence population growth. Flow alteration has been linked to declines and extirpations in the Foothill Yellow‐legged Frog (Rana boylii), a stream breeding amphibian native to California and Oregon. To date, no study has jointly analyzed abundance data from populations throughout the range of R. boylii in an MPVA model. We compiled time series of egg mass counts (an index of adult female abundance) from R. boylii populations in 36 focal streams and fit an MPVA model to quantify how streamflow metrics, stream temperature, and surrounding land cover affect population growth. We found population growth was positively related to stream temperature and was higher in the years following a wet year with high total annual streamflow. Density dependence was weakest (i.e., carrying capacity was highest) for streams with high seasonality of streamflow and intermediate rates of change in streamflow during spring. Our results highlight how altered streamflow can further increase the risk of decline for R. boylii populations. Managing stream conditions to better match natural flow and thermal regimes would benefit the conservation of R. boylii populations.
GDF‐15 at admission predicts cardiovascular death, heart failure, and bleeding outcomes in patients with CAD
Authors: Wang Jiali , Zhang Tao , Xu Feng , Gao Wei , Chen Ming , Zhu Huadong , Xu Jun , Yin Xinxin , Pang Jiaojiao , Zhang Song , Wei Mengke , Chen Jiahao , Liu Ying , Yu Xuezhong , Chew Derek P. , Chen Yuguo 
Published: August 2023

AbstractAimsWe aimed to investigate the independent associations between growth differentiation factor 15 (GDF‐15) level at admission and cardiovascular (CV) death, thrombotic events, heart failure (HF), and bleeding outcomes in patients with coronary artery disease (CAD).Methods and resultsWe measured the plasma concentrations of GDF‐15 centrally in patients from the BIomarker‐based Prognostic Assessment for patients with Stable angina and acute coronary Syndrome (BIPass) registry, which consecutively enrolled patients with CAD from November 2017 to September 2019 at five tertiary hospitals in China. The outcomes included CV death, thrombotic events [myocardial infarction (MI) and ischaemic stroke], HF events [acute HF during hospitalization and hospitalization for HF post‐discharge (A/H HF) and cardiogenic shock], and bleeding outcomes [non‐coronary artery bypass grafting‐related major bleeding and clinically significant bleeding (CSB)] during the 12 month follow‐up period after hospitalization. Among 6322 patients with CAD {65.4% male, median age 63.7 [inter‐quartile range (IQR)] 56.0–70.1 years}, the median concentration of plasma GDF‐15 at admission was 1091 (IQR 790.5–1635.0) ng/L. Higher concentrations of GDF‐15 were associated with an increased risk of CV death [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.35–2.88, P < 0.001], A/H HF (HR 2.69, 95% CI 1.92–3.77, P < 0.001), cardiogenic shock (HR 1.46, 95% CI 1.04–2.05, P = 0.029), and CSB (HR 1.48, 95% CI 1.22–1.79, P < 0.001), but not for MI or stroke, after adjusting for clinical risk factors and prognostic biomarkers. Adding GDF‐15 to the model with risk factors and biomarkers improved the net reclassification for CV death, A/H HF, cardiogenic shock, and CSB.ConclusionsIn patients with CAD, admission levels of GDF‐15 were associated with an increased 1 year risk of CV death, HF, and bleeding outcomes, but not with thrombotic events. GDF‐15 may be a prognostic biomarker for CV death, HF, and bleeding outcomes and could be used to refine the risk assessment of these specific clinical outcomes.Trial Registration: ClinicalTrials.gov Identifier: NCT04044066
A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody‐mediated immune responses
Authors: Thaller Anna Louisa , Jönsson Friederike , Fiquet Oriane , Marie Solenne , Doisne Jean‐Marc , Girelli‐Zubani Giulia , Eri Toshiki , Fernandes Priyanka , Tatirovsky Evgeny , Langa‐Vives Francina , Bruhns Pierre , Strick‐Marchand Hélène , Di Santo James P. 
Published: August 2023

AbstractHuman immune system (HIS) mice provide a model to study human immune responses in vivo. Currently available HIS mouse models may harbor mouse Fc Receptor (FcR)‐expressing cells that exert potent effector functions following administration of human Ig. Previous studies showed that the ablation of the murine FcR gamma chain (FcR‐γ) results in loss of antibody‐dependent cellular cytotoxicity and antibody‐dependent cellular phagocytosis in vivo. We created a new FcR‐γ‐deficient HIS mouse model to compare host (mouse) versus graft (human) effects underlying antibody‐mediated immune responses in vivo. FcR‐γ‐deficient HIS recipients lack expression and function of mouse activating FcRs and can be stably and robustly reconstituted with human immune cells. By screening blood B‐cell depletion by rituximab Ig variants, we found that human FcγRs‐mediated IgG1 effects, whereas mouse activating FcγRs were dominant in IgG4 effects. Complement played a role as an IgG1 variant (IgG1 K322A) lacking complement binding activity was largely ineffective. Finally, we provide evidence that FcγRIIIA on human NK cells could mediate complement‐independent B‐cell depletion by IgG1 K322A. We anticipate that our FcR‐γ‐deficient HIS model will help clarify mechanisms of action of exogenous administered human antibodies in vivo.
Visible‐Light‐Driven Three‐Component Reaction of Unactivated Alkenes Enables Access to Monofluoro γ‐Amino Acids
Authors: Ju Guodong , Huang Zhibin , Liu Jian , Xu Xu , Deng Zefeng , Zhao Yingsheng 
Published: August 2023

AbstractA strategy for the synthesis of diverse protected α‐monofluoro‐γ‐amino acid derivatives has been developed. This reaction assembles a simple enamide, quinoxalin‐2(1H)‐one, and diethyl 2‐bromo‐2‐fluoromalonate through a three‐component reaction driven by visible light. The advantages of this protocol include the simplicity of its operation, mild conditions, high functional group tolerance, and applicability to a wide variety of substrates. The synthesis of this fluorine‐containing amino acid derivative has significant value for potential applications in medicinal chemistry and chemical biology.
First Asymmetric Total Synthesis of Salinosporamides D and I Using Memory of Chirality and Dynamic Kinetic Resolution
Authors: Park Soojun , Jeong Yeji , Lim Changhyun , Kim Sanghee 
Published: August 2023

AbstractThe first total synthesis of (−)‐salinosporamide D was achieved using d‐serine as the sole chiral source. This approach stands out for its application of the principles of memory of chirality and dynamic kinetic resolution in the intramolecular aldol reaction of serine‐derived oxazolidines. These strategies enabled the rapid construction of a pyrrolidinone core and installation of contiguous stereocenters. The key intermediate was readily obtained, culminating the asymmetric total synthesis of salinosporamide D. The total synthesis of salinosporamides A and I was also achieved using the same chemistry.
Prejudice among egalitarians: The case of values and weight bias
Authors: Souchon Nicolas , Hanel Paul H. P. , Coutte Alexandre , Maio Gregory R. 
Published: August 2023

AbstractMany domains of research suggest that high favourability to social power and low favourability to egalitarian ideals predict more prejudice against other groups. In the present article, we describe theory and evidence suggesting that the relations between power, egalitarianism and prejudice may be reversed for one group: fat men. Using both implicit and explicit measures, we found across four studies (N = 602) that target gender moderated the relation between values and attitude toward fat people. For male targets, implicitly but not explicitly measured positivity toward power (over egalitarian) values predicted significantly more spontaneous positive attitudes toward fat (over slim) people. Further, implicit attitude toward power (over egalitarian) values predicted the time‐pressured decision to choose a fat male. Together, the implicit evaluation of values allows us to identify processes in inter‐group attitudes and behaviours that would not be possible to detect using explicit measures of values alone.
Joint loan risk prediction based on deep learning‐optimized stacking model
Authors: Wang Yansong , Wang Meng , Pan Yong , Chen Jian 
Published: August 2023

AbstractIn recent years, China's automobile industry has undergone rapid development, creating new opportunities for the auto loan industry. Currently, auto financing companies are actively seeking to expand their cooperation with banks. Therefore, improving the approval rate and scale of joint loan business is of significant practical importance. In this paper, we propose a Stacking‐based financial institution risk approval model and select the optimal stacking model by comparing its performance with other models. Additionally, we construct a bank approval model using deep learning techniques on a biased data set, with feature extraction performed using convolution neural networks (CNN) and feature‐based counterfactual augmentation used for balanced sampling. Finally, we optimize the model of the prediction of auto finance companies by selecting the optimal coefficients of loss function based on the features and results of the bank approval model. The proposed approach leads to an approximately 6% increase in the joint loan approval rate on the actual data set, as demonstrated by experimental results.
Alloplastic reconstruction of the mandible after subtotal mandibulectomy for medication‐related osteonecrosis of the jaw: An update of the method
Authors: Bräuer Christian , Ullmann Katrin , Lauer Günter , Franke Adrian , McLeod Niall M. H. , Leonhardt Henry 
Published: August 2023

AbstractBackgroundReconstruction of continuity defects following osteonecrosis in multimorbid patients is challenging. In all cases of the predescribed palliative treatment method for alloplastic mandible reconstruction, plate fractures were detected in follow‐up. We hypothesized that a modification could avoid these fractures, leading to stable long‐term results.MethodsThis retrospective study compares the original method with a modification using single, laser‐sintered CAD–CAM plates instead of manually bent miniplates. The predescribed shuttering technique was used to reconstruct the mandible in its original shape with bone cement.ResultsUneventful wound healing was observed in 86% of the cases after modification of the method. No implant or plate fracture occurred.ConclusionsThe presented method should be considered as a treatment option for mandible reconstruction in elderly, multimorbid patients in palliative situations. The results of this study suggest that the modification of the method leads to significantly improved long‐term stability. Donor site morbidity is avoided with this method of palliative surgery.
Gastrostomy dependence following pharyngolaryngectomy: The effect of preoperative tube insertion
Authors: Milinis Kristijonas , Parikh Chinar , Williams Stephen , Davies Katharine , Fleming Jason C. 
Published: August 2023

AbstractBackgroundThe aim of this study is to investigate the impact of preoperative gastrostomy in patients undergoing pharyngolaryngectomy (PL) on gastrostomy tube dependence at 6 months postoperatively.MethodsA retrospective review of patients undergoing PL for laryngeal squamous cell carcinoma between 2005 and 2019 was performed. Parameters were collected and analyzed within the multivariate models.ResultsNinety‐three patients (82% male, mean age 63.4 [SD 9.4]) were included. Preoperative tube placement and pharyngocutaneous fistula (PCF) were associated with an increased likelihood of gastrostomy tube dependence at 6 months (odds ratio 6.43, CI 1.1–38.3, p = 0.041) after adjusting for multiple confounding factors. There was no difference in the incidence of delayed oral feeding, PCF, or hospital stay between the groups.ConclusionsPreoperative tube and PCF are associated with an increased likelihood of tube dependence at 6 months. Patients for preoperative tube insertion should be carefully selected and early oral feeding reintroduction should be encouraged.
Estimation of the soil hydraulic properties and parameter characteristics of Benggang erosion in granite in southern China
Authors: Lin Zhe , Liao Dalan , Huang Wanxia , Cai Chongfa , Deng Yusong , Duan Xiaoqian 
Published: August 2023

AbstractBenggang is an erosional landform that forms in granite hills due to coupled hydraulic and gravity erosion, and its unique development makes it difficult to obtain moisture characteristics through direct means. In this study, the soil moisture characteristics were investigated on the collapsing walls with different weathering degrees of two different Benggang types defined as scoop‐shaped Benggang and strip‐shaped Benggang in the typical Benggang erosion areas of southeastern Guangxi. The soil water characteristic curves (SWCCs) of the collapsing wall were measured by the centrifuge method to explore the moisture transport mechanism of Benggang development. The response of moisture characteristics to the Benggang morphology was not significant, but the soil layer changes in the collapsing wall had a significant impact. The Atterberg limits of the surface layer and laterite layer were significantly higher than those of the transition layer and sandy layer, with a liquid limit (LL) value exceeding 55%, indicating high LL clay. The Van Genuchten (VG), Gardner and Fredlund–Xing (FX) models were used to fit the SWCCs, and the results indicated that the VG model had a high fitting accuracy (R2 > 0.984), followed by the FX model (R2 > 0.943); however, the Gardner model had a low fitting accuracy (R2 > 0.891). With the change in matrix suction, the sandy layer had the maximum water release capacity, followed by the transition layer, and finally the surface layer and laterite layer. The variation in equivalent pore size distributions with soil layers showed that the micropores in the laterite layer of the two Benggangs accounted for 44.91% and 44.38% of the total porosity. The macropores of the sandy layer accounted for 35.40% and 36.84% of the total porosity. Both the unsaturated hydraulic conductivity K(θ) and water diffusivity D(θ) exhibited two abrupt changes with increasing soil volumetric water content, and K(θ) and D(θ) of the lower layers were larger than those of the upper layers. The heterogeneity of soil texture and pore conditions among different collapsing wall soil layers can significantly affect the Benggang water conditions. This study provides a database for further investigation of the Benggang development mechanism.