bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Highly Efficient Aorta-Gonad-Mesonephros-Like Definitive Hemogenic Endothelium From Human Pluripotent Stem Cells
Authors: Fstkchyan Yesai , Cheng Qingwen , Zhang Jingli , Lu Daniel , Huang Guanyi , Dong Tiange , Jones Lauren , Kanke Matt , Hale Chris , Tarbell Kristin , Li Chi-Ming , Wang Songli , Chambers Stuart M. 
Published: June 2023

Summary/AbstractHuman pluripotent stem cells are a tremendous tool to model early human development and disease including their use in thein vitrogeneration of blood cell fates. Hematopoietic progenitors and stem cells are the primary source of blood and the immune system from early development to adulthood and arise through successive waves of hemogenic mesoderm either in the yolk sac or embryo proper. Researchers have long sought a tractable human model for observing and distinguishing these waves of hematopoiesis in the dish for human developmental and disease modeling. Here we report a high-efficiency method for differentiating human pluripotent stem cells into an aorta-gonad-mesonephros-like definitive hemogenic mesoderm capable of giving rise to definitive hematopoietic progenitor and stem cells. The hematopoietic progenitor and stem cells exhibit robust multilineagein vitrocolony forming potential. Gene expression analysis and single cell sequencing strongly support the developmental timing and notion that the pluripotent stem cell derived hematopoietic stem and progenitors are strikingly likebone fidehematopoietic stem cells. The hematopoietic progenitors can be subsequently differentiated into polarized macrophage and T-cellsin vitro. Minimal silencing was observed upon differentiation of the pluripotent stem cells to hematopoietic lineages when conducting gene editing. Finally, upon engraftment into immunodeficient animals the hematopoietic progenitors and stem cells differentiate into multiple lineages including B-cells, T-cells, NK-cells, and monocytes.
Knowledge organisation in institutional repositories: a case study on policies and procedures manuals in the Ibero-American environment
Authors: Bueno de la Fuente Gema , Agustín-Lacruz Carmen , Fujita Mariângela Spotti Lopes , Terra Ana Lúcia 
Published: June 2023

Purpose
The purpose of this study is to analyse the recommendations on knowledge organisation from guidelines, policies and procedure manuals of a sample of institutional repositories and networks within the Latin American area and observe the level of follow-up of international guidelines.

Design/methodology/approach
Presented is an exploratory and descriptive study of repositories’ professional documents. This study comprised four steps: definition of convenience sample; development of data codebook; coding of data; and analysis of data and conclusions drawing. The convenience sample includes representative sources at three levels: local institutional repositories, national aggregators and international network and aggregators. The codebook gathers information from the repositories’ sample, such as institutional rules and procedure manuals openly available, or recommendations on the use of controlled vocabularies.

Findings
The results indicate that at the local repository level, the use of controlled vocabularies is not regulated, leaving the choice of terms to the authors’ discretion. It results in a set of unstructured keywords, not standardised terms, mixing subject terms with other authorities on persons, institutions or places. National aggregators do not regulate these issues either and limit to pointing to international guidelines and policies, which simply recommend the use of controlled vocabularies, using URIs to facilitate interoperability.

Originality/value
The originality of this study lies in identifying how the principles of knowledge organisation are effectively applied by institutional repositories, at local, national and international levels.
How does millennial employee job satisfaction affect performance?
Authors: Indrayani Indrayani , Nurhatisyah Nurhatisyah , Damsar Damsar , Wibisono Chablullah 
Published: June 2023

PurposeThis study aims to test and analyze the effect of continuous commitment, task complexity, competence and personal value on employee performance millennial intervening job satisfaction.Design/methodology/approachThis research method is quantitative with a sequential explanatory design, then data collection through a questionnaire, with a sample of 205 respondents—data analysis using Structural Equation Model (SEM) with the software Linear Structural Relationship (LISREL).FindingsThe results of research on the performance of millennial employees with intervening work satisfaction showed that continuous commitment (2.49), task complexity (2.74) and professional competence (2.0) had a significant effect. This means that the performance of millennial employees will increase if they get job satisfaction. With satisfaction, the commitment and competence of millennial employees are high. While the research results for the performance of millennial employees have a direct influence, only professional competence (2.27) and task complexity (4.06) are significant. This means that as high as professional competence is characterized by intellectual, emotional mood and attitude, owned by millennial employees, the resulting performance is increased even with complex tasks.Research limitations/implicationsThe findings of this study have significance for enhancing organizational performance so that businesses can maximize the performance of millennial employees by paying attention to job satisfaction, professional competence and personal values.Originality/valueThis research's contribution to millennial workers is to help them improve and develop their performance, allowing them to compete more effectively. The findings of this study have significance for enhancing organizational performance so that businesses can maximize the performance of millennial employees by paying attention to job satisfaction, professional competence and personal values.
Numerical study on shell and tube heat exchangers with different baffles configurations
Authors: Youcef Ahmed , Saim Rachid , Öztop Hakan F. 
Published: June 2023

Purpose
The purpose of this paper is to give a comparison between different type of baffles for a better application. Computational analysis of heat transfer and fluid flow through plain, flower and perforated baffles for heat exchanger.

Design/methodology/approach
Numerical simulations for heat exchangers with plain, flower and perforated baffles are carried out with finite volume method. The thermal-hydraulic performance for the three types is presented in the same conditions.

Findings
The perforated baffles generate low shell pressure with high Nusselt number; transverse baffles give the best heat transfer with high pumping power. The overall performance coefficient of these three types of heat exchangers shows that the perforated baffles have a highest and the transverse baffles have the lowest. Analysis of the results show that perforated transverse baffles produce pressure drop lower by 6.68% than transverse baffles and 2.64% lower than flower baffles. The pumping power for perforated transverse baffles lower by 13.3% to the transverse baffles and 4.72% lower than that of flower baffles. The Nusselt number for perforated baffles higher by 4.16% to the flower baffles and 2.77% with transverse baffles. The overall performance factor in the heat exchanger with perforated baffles higher by 5.55% to that with transverse baffles and 3.46% with flower baffles. Recirculation areas are reduced in shell with perforated baffles and velocity distribution becomes more uniform.

Originality/value
Using of perforated baffles in heat exchanger give the best overall performance factor.
“Overcrowded but lonely”: exploring mental health and well-being among young prisoners in Cambodia
Authors: Pat Puthy , Edin Kerstin , Jegannathan Bhoomikumar , San Sebastian Miguel , Richter Sundberg Linda 
Published: June 2023

Purpose
Young prisoners are one of the most vulnerable groups in society for mental health problems and ill-being. Therefore, there is a crucial need to understand their physical, psychological and social situations. This study aims to explore young Cambodian prisoners’ experiences and perceptions of mental health and well-being, their determinants and their coping strategies.

Design/methodology/approach
Six focus group discussions were carried out in three prisons with a total of 48 young prisoners between the ages of 15 and 24 years (50% women, 50% men). Semi-structured questions guided the discussions, and thematic analysis was applied to analyse the data.

Findings
Young prisoners reported multifaceted experiences of mental health and well-being. The majority described adverse mental health experiences, while some revealed better well-being, partly influenced by the socio-economic support from outside the prisons and previous involvement or not in drug abuse. The experience of physical overcrowding without emotional attachment among the fellow prisoners was perceived as the overarching determinant of loneliness and mental health problems, while socio-emotional support and rituals were described as the most important coping mechanisms.

Originality/value
This pioneering study from Cambodia gives young prisoners an opportunity to voice their experiences and perceptions of mental health and well-being in the prison setting. The findings in this study underline the importance of prison authorities tackling overcrowding to promote well-being and reduce mental health problems. Also, the coping mechanisms outlined by the participants should be considered when planning psychosocial interventions.
The role of self-efficacy on feelings of burnout among Flemish school principals during the COVID-19 pandemic
Authors: Bellemans Lore , Devos Geert , Tuytens Melissa , Vekeman Eva 
Published: June 2023

PurposeWork-related stress is a significant occupational health issue. Stress cannot be viewed separately from the perceptual or interpretive act by the individual. Self-efficacy is a personal characteristic that explains a high proportion of variation in the performance of school principals.Design/methodology/approachThe current study examines if the COVID-pandemic is related to burnout among school principals. Additionally, the study analyzes if the self-efficacy of school principals plays a mediating role in the impact that the COVID-19 crisis had on their burnout level. To explore this, the authors used survey data of 981 Flemish school principals.FindingsThe findings indicate that the COVID-19 pandemic is related to feelings of burnout among Flemish school principals. In addition, self-efficacy mediated the relationship between the COVID-19 scale and the four core subscales of burnout: exhaustion, mental distance, emotional impairment and cognitive impairment. No mediating effect of self-efficacy was found for the secondary symptoms of burnout, psychological distress and psychosomatic complaints.Originality/valueThis paper emphasizes the importance of school principal's self-efficacy experiences for crisis management. Implications for school leadership training and support are discussed.
Social capital and sustainable growth of full-service restaurants in the global south: testing the mediating role of dynamic capabilities
Authors: Najjinda Shamirah , Sendawula Kasimu , Otengei Samson Omuudu , Walugembe Ahmad , Kimuli Saadat Nakyejwe Lubowa 
Published: June 2023

PurposeThe purpose of this study is to establish whether dynamic capabilities mediates the association between social capital and sustainable growth of full-service restaurants in Kampala, Uganda.Design/methodology/approachThis study is cross-sectional and correlational in nature. A self-administered questionnaire was used to gather data from 154 full-service restaurants in Kampala. Statistical Package for the Social Sciences (SPSS.25) and Medgraph – Excel Version were used to conduct correlation, hierarchical regression and mediation analysis on the data in order to establish the mediating role of dynamic capabilities.FindingsStudy findings revealed that first, social capital and dynamic capabilities significantly predict sustainable growth of full-service restaurants, second, social capital is significantly associated with dynamic capabilities and third, dynamic capabilities significantly mediate social capital and sustainable growth of full-service restaurants.Originality/valueThe study confirmed that dynamic capabilities significantly mediate social capital and sustainable growth of full-service restaurants unlike the previous studies that focused on the direct association between the study variables in explicating sustainable growth.
Building technical, human and conceptual skills: implications for Vietnamese librarians
Authors: Tran Quan Hoang Nguyen 
Published: June 2023

PurposeThis study examines the working skills of Vietnamese librarians in terms of technical, human and conceptual skills. Then, this study suggests recommendations to improve their working skills.Design/methodology/approachTo attain this objective, the study surveyed 243 Vietnamese librarians. Several statistical tests, including analysis of variance (ANOVA) and the paired t-test, were used to investigate differences in respondents' responses based on demographic variables such as gender, age, education and managerial level.FindingsGender appears to impact the working skill of Vietnamese librarians. In detail, the findings indicate that male librarians have higher technical skills than female librarians.Research limitations/implicationsThis study opens the scope of working skill literature, particularly in the library sector. Notably, this is the first study investigating this issue in Vietnam. Given the current circumstances, suggesting practical recommendations to enhance the working skills of Vietnamese libraries is essential.Originality/valueThis is the first study examining Vietnamese librarians in technical, human and conceptual skills. Therefore, this research is essential in this field.
Glycoprotein M6A upregulation detected by transcriptome analysis controls the proliferation of keloidal fibroblasts
Authors: Kurimoto‐Nishiguchi Mana , Muraoka Kyoko , Inaba Yutaka , Kunimoto Kayo , Yamamoto Yuki , Kumegawa Shinji , Ueno Kazuki , Asamura Shinichi , Nakatani Yumi , Sawamura Soichiro , Makino Katsunari , Jinnin Masatoshi 
Published: June 2023

AbstractHypertrophic scars and keloids are fibroproliferative disorders caused by abnormal wound healing. Their exact cause has not been found, but abnormalities during the wound healing process including inflammatory, immune, genetic, and other factors are thought to predispose an individual to excessive scarring. In the present study, we performed transcriptome analysis of established keloid cell lines (KEL FIB), focusing on gene expression analysis and fusion gene detection for the first time. For gene expression analysis, fragments per kilobase per million map read values were calculated, which were validated by real‐time PCR and immunohistochemistry. Fusion genes were predicted by transcriptome sequence, and validated by Sanger sequence and G‐banding. As a result, GPM6A was shown in the expression analysis to be upregulated in KEL FIB compared with normal fibroblasts. The GPM6A upregulation in KEL FIB was confirmed by real‐time PCR, and GPM6A messenger ribonucleic acid expression was consistently significantly elevated in the tissues of hypertrophic scar and keloid compared to normal skin. Immunohistochemistry also revealed that the number of fibroblast‐like spindle‐shaped cells positive for GPM6A was significantly increased in keloidal tissues. GPM6A inhibition by small interfering ribonucleic acid significantly reduced the number of KEL FIB. On the other hand, although we hypothesized that fusion genes are involved in the pathogenesis of keloids, the transcriptome analysis could not prove the presence of fusion genes in KEL FIB. Taken together, GPM6A upregulation may have an inducible effect on cell proliferation in keloidal fibroblasts. GPM6A can be a novel therapeutic target in hypertrophic scars and keloids. The inflammatory nature may be more prominent in the pathogenesis of keloids, rather than being skin tumors, as proposed by Ogawa et al. Future studies using several cell lines will be required.
The growth impacts of agriculture value‐added, energy utilization, and environmental degradation in Pakistan: Causality in continuous wavelet transform approach
Authors: Adebayo Tomiwa Sunday , Alola Andrew A. , Ullah Sami , Abbas Shujaat 
Published: June 2023

AbstractConsidering the increasing challenge to Pakistan's sustainable economic growth and development, the current study posits a fresh perspective on the dimension of attainable sustainable economic growth in the country. Based on this, a more innovative Granger causality of wavelet coherence and frequency domain approaches are employed to proffer inference for the relationship between economic growth, agriculture value‐added, energy utilization, urbanization, and environmental degradation via carbon dioxide (CO2) emissions over the period 1965 to 2021. The result reveals that economic growth in Pakistan is positively related to the aforementioned variables with a significant dimension. Moreover, with a statistically significant degree of evidence, there is bidirectional causality between energy utilization and economic expansion. Similarly, there is a significant bidirectional causality between environmental degradation (as captured by carbon emission) and economic expansion. This better translates that historical information of energy utilization and carbon emissions could explain the future dimension of economic growth in Pakistan and vice versa. Expectedly, increasing urbanization and value‐added from the agricultural sector of the economy both Granger causes economic growth in Pakistan. The implication for the policymaker is that as much as economic growth is a vital indicator of sustainable development, the policy initiatives should reflect environmental, energy development, agricultural sector, and urban activities dimensions.
Performance of eye sign combined with increased interleukin‐6 in cerebrospinal fluid in patients with neuropsychiatric lupus erythematosus
Authors: Shi Lin‐Hong , Liu Ze‐Yang , Yu Shu‐Jiao , Xia Qiang , Zhao Jun , Wu Rui 
Published: June 2023

AbstractObjectivesTo ascertain whether microvascular alterations of eye sign combined with intrathecal concentrations of interleukin‐6 (IL‐6) can predict the development of neuropsychiatric systemic lupus erythematosus (NPSLE).MethodsCerebrospinal fluid (CSF) and serum samples of IL‐6 were collected and measured at the same time for patients with SLE who were consecutively enrolled. Patients with a diagnosis of NPSLE were identified. Eye sign examinations according to our criteria were performed and scored for all SLE patients. Demographic and clinical parameters were compared between groups to identify potential predictors for NPSLE using multivariable logistic regression analysis. The performance of potential predictors from eye sign along with IL‐6 in the CSF was assessed.ResultsA total of 120 patients with SLE were enrolled; 30 with NPSLE and 90 with non‐NPSLE. No significant positive correlation was observed between CSF level and serum level of IL‐6. CSF IL‐6 was significant higher in the NPSLE group than the non‐NPSLE (P < 0.001) group. Multivariable logistic analysis revealed that total score, ramified loops, and microangioma of eye sign were predictors for NPSLE after adjusting for SLE Disease Activity Index (SLEDAI) and antiphospholipid antibody (APL). Total score, ramified loops, microangioma of eye sign, and SLEDAI remain significant predictors for NPSLE after adjusting for CSF IL‐6. Using receiver operating characteristics curve analysis, the cut‐off point of potential predictors was applied in multivariable logistic analysis; APL, total score, ramified loops, and microangioma of eye sign remain significant predictors for NPSLE after adjusting for CSF IL‐6.ConclusionSpecific microvascular alterations of eye sign are predictors for the development of NPSLE in addition to increased IL‐6 in the CSF.
Ethanol inhibition of undifferentiated rat neural progenitor cell replication can be prevented by chlorogenic acid via the NFATc4/CSE signaling pathway
Authors: Shanmugam Sambantham , Patel Dhyanesh , Rodriguez Angelica L. , Walchale Aashlesha , Liu Xiaobo , Bergeson Susan E. , Mahimainathan Lenin , Narasimhan Madhusudhanan , Henderson George I. 
Published: June 2023

AbstractBackgroundPrenatal ethanol exposure hinders oxidative stress‐mediated neuroblast/neural progenitor cell proliferation by inhibiting G1‐S transition, a process vital to neocortical development. We previously showed that ethanol elicits this redox imbalance by repressing cystathionine γ‐lyase (CSE), the rate‐limiting enzyme in the transsulfuration pathway in fetal brain and cultured cerebral cortical neurons. However, the mechanism by which ethanol impacts the CSE pathway in proliferating neuroblasts is not known. We conducted experiments to define the effects of ethanol on CSE regulation and the molecular signaling events that control this vital pathway. This enabled us to develop an intervention to prevent the ethanol‐associated cytostasis.MethodsSpontaneously immortalized undifferentiated E18 rat neuroblasts from brain cerebral cortex were exposed to ethanol to mimic an acute consumption pattern in humans. We performed loss‐ and gain‐of‐function studies to evaluate whether NFATc4 is a transcriptional regulator of CSE. The neuroprotective effects of chlorogenic acid (CGA) against the effects of ethanol were assessed using ROS and GSH/GSSG assays as measures of oxidative stress, transcriptional activation of NFATc4, and expression of NFATc4 and CSE by qRT‐PCR and immunoblotting.ResultsEthanol treatment of E18‐neuroblast cells elicited oxidative stress and significantly reduced CSE expression with a concomitant decrease in NFATc4 transcriptional activation and expression. In parallel, inhibition of the calcineurin/NFAT pathway by FK506 exaggerated ethanol‐induced CSE loss. In contrast, NFATc4 overexpression prevented loss of ethanol‐induced CSE. CGA increased and activated NFATc4, amplified CSE expression, rescued ethanol‐induced oxidative stress, and averted the cytostasis of neuroblasts by rescuing cyclin D1 expression.ConclusionsThese findings demonstrate that ethanol can perturb CSE‐dependent redox homeostasis by impairing the NFATc4 signaling pathway in neuroblasts. Notably, ethanol‐associated impairments were rescued by genetic or pharmacological activation of NFATc4. Furthermore, we found a potential role for CGA in mitigating the ethanol‐related neuroblast toxicity with a compelling connection to the NFATc4/CSE pathway.
Mandatory inclusive finance policy and small banks' operating performance: Evidence from China
Authors: Ma Dan , Wang Wenchun 
Published: June 2023

AbstractWe take the mandatory establishment of the Inclusive Finance Division in large state‐owned banks as a quasi‐experiment to explore the impact of inclusive finance policy on operating performance and risk‐taking behaviours of small regional banks. Using financial information for Chinese banks from 2013 to 2019, we find that small regional banks' performance deteriorated, and they engaged in more risk‐taking activities after the policy shock. Moreover, there are even much sharper performance declines in subsets of city commercial banks, and banks face high competition from large state‐owned banks.