bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing Landscape of Head and Neck Squamous Cell Carcinoma and Nasopharyngeal Carcinoma Treatment and Survival Trends in Thailand: A 13-Year Multicenter Retrospective Study of Patients
Authors: Ngamphaiboon Nuttapong , Dechaphunkul Arunee , Vinayanuwattikun Chanida , Danchaivijitr Pongwut , Thamrongjirapat Thanaporn , Prayongrat Anussara , Dechaphunkul Tanadech , Jiratrachu Rungarun , Pattaranutaporn Poompis , Jiarpinitnun Chuleeporn , Setakornnukul Jiraporn 
Published: January 2025

PURPOSE
The incidence and survival rates of head and neck squamous cell carcinoma (HNSCC) and nasopharyngeal carcinoma (NPC) vary globally, influenced by factors such as ethnicity, lifestyle, and health care systems.

METHODS
A retrospective analysis was conducted on patients with HNSCC treated between 2008 and 2020 in four major Thai academic cancer centers, using a multidisciplinary multicenter database. The study focused on the evolution of patient characteristics, survival changes, and treatment landscape alterations over time.

RESULTS

Among 6,319 patients, the most common primary sites were nasopharynx (33%), oral cavity (23%), oropharynx (17%), larynx (15%), and hypopharynx (8%). An increase in human papillomavirus–related oropharyngeal carcinoma was noted, from 13% in 2008 to 42% in 2019-2020. The majority of patients presented with locally advanced (LA) stages (IVa/b: 50%, III: 26%). Chemoradiotherapy (54%) and surgery (24%) were the main treatments, with cisplatin (79%) being most commonly used in chemoradiation. Overall survival (OS) improved annually across all subsites, correlating with an increase in intensity-modulated radiotherapy (IMRT) use, from 25% in 2008 to 90% in 2019-2020. The median follow-up duration was 4.59 years, with a minimum of 2.75 years. Patients treated with IMRT had significantly longer OS compared with those treated with non-IMRT techniques, in both NPC and non-NPC HNSCC (
P
< .001).

CONCLUSION
To our knowledge, this is the largest study in Thailand that demonstrates increasing survival outcomes in patients with HNSCC and NPC, despite commonly presenting with LA stages. The increasing use of IMRT may be contributing to improved survival outcomes in both patients with NPC and non-NPC HNSCC patients.
Incidence of Cancers in Kerala, India: A Review of Population-Based Registry Data
Authors: Boby Jeffrey Mathew , Varughese Deepak , Benny Jame Mathew , Thomas Mathew , Mathew Aju 
Published: January 2025

PURPOSE
Kerala in India leads the nation in both Human Development Index and Sustainable Development Index. The state is a harbinger for the rest of the country in matters of health. Documentation of cancer trends and quantifying the cancer burden is crucial for planning oncology services in the country. In this study, we aim to perform a time series analysis using data from the National Cancer Registry.

METHODS
Data for crude incidence, age-adjusted incidence, and disease-specific incidence were extracted from published reports of the Population-Based Cancer registries at Kollam and Thiruvananthapuram. Data collected between 2006 and 2008 were analyzed and published in 2010. Data collected between 2012 and 2016 were published in 2020. Descriptive statistics was used for analysis.

RESULTS
Age-adjusted incidence rates increased from 121.7 per 100,000 men to 137.8 in Thiruvananthapuram from 2006-2008 to 2012-2016 period. Among women, in Thiruvananthapuram, the age-adjusted rates increased from 108.3 to 127.3. In Kollam, the age-adjusted incidence rate increased from 113.3 to 127.1 among men and 89.7 to 107.1 among women. Lung and breast cancers remain the most common cancers among men and women.

CONCLUSION
There has been an increase in both crude and age-adjusted incidence rates in Kerala. However, these changes are in line with global trends in cancer incidence. Lifestyle changes and reduced tobacco and alcohol use will help decrease the incidence of cancer in Kerala.
Detecting Early Recurrence With Circulating Tumor DNA in Stage I-III Biliary Tract Cancer After Curative Resection
Authors: Yu James , He Aiwu Ruth , Ouf Mahmoud , Mehta Rutika , Anaya Daniel A. , Denbo Jason , Bridges Catherine , Tin Antony , Aushev Vasily N. , Palsuledesai Charuta C. , Sharma Shruti , Jurdi Adham , Liu Minetta C. , Kim Richard D. 
Published: January 2025

PURPOSE
This study aimed to assess (1) the prognostic value of circulating tumor DNA (ctDNA) and (2) the ability of ctDNA to detect recurrence compared with standard surveillance in curatively resected early-stage biliary tract cancer (BTC).

METHODS
This retrospective, multicenter cohort study evaluated serial ctDNA testing for surveillance in patients with early-stage BTC after curative resection. We evaluated the relapse-free survival (RFS) by ctDNA positivity. The sensitivity of ctDNA in detecting a confirmed recurrence of BTC, defined as a biopsy-proven or true progression by radiographic tumor dynamics, was evaluated. The lead time was calculated from the first ctDNA detection to the confirmed recurrence.

RESULTS

A total of 56 patients with curatively resected stage I-III BTC were included in this study, with a median follow-up of 12.8 months from the date of surgery. ctDNA detection during the molecular residual disease window period (median RFS, 6.6 months
v
not reached; hazard ratio [HR], 26 [95% CI, 2.6 to 265];
P
< .0001) and during the surveillance period (median RFS, 19.3 months
v
not reached; HR, 20 [95% CI, 2.6 to 153];
P
< .0001) were associated with poorer RFS. Sixteen patients had confirmed recurrence. ctDNA identified recurrence in 93.8.% (15/16) of the recurred patients with an average lead time of 3.7 months. Carbohydrate antigen 19-9 levels did not show any significant correlation with RFS (HR, 1.17 [95% Cl, 0.24 to 5.71];
P
= .844) in contrast to ctDNA.

CONCLUSION
The findings from our real-world cohort study revealed the (1) promising value of ctDNA as a prognostic biomarker for relapse in curatively resected BTC and (2) potential early detectability of recurrence by ctDNA compared with standard surveillance.
Clinical Outcomes and Molecular Profiling of Pancreatic Acinar Cell Carcinoma: A Retrospective Study
Authors: Eslinger Cody , Seddighzadeh Bobak , Yee Claire , Elsabbagh Zaid , Pai Rish , Hartley Chris , Starr Jason , Bekaii-Saab Tanios , Halfdanarson Thorvardur R. , Sonbol Mohamad Bassam 
Published: January 2025

PURPOSE
Pancreatic acinar cell carcinoma (PACC) is a rare and aggressive form of pancreatic cancer that originates in the acinar cells of the exocrine pancreas. In this study, we aimed to investigate the clinical and molecular characteristics of patients with PACC at our institution.

METHODS
This was a retrospective study of patients with PACC seen at Mayo Clinic between 2002 and 2023. Baseline patient characteristics, tumor pathology, treatment strategies used, and survival outcomes were analyzed. Kaplan-Meier curves were estimated using newsurv macros in SAS.

RESULTS

The study included a total of 65 patients with PACC. The median age at diagnosis was 66 years. Almost half of the patients (48%) presented with resectable/borderline-resectable disease (n = 28). Five-year overall survival (OS) for resectable/borderline-resectable, locally advanced/unresectable, and metastatic disease were 72.0%, 21.6%, and 20.9%, respectively. Somatic and germline next-generation sequencing identified numerous potentially actionable targets including homologous recombination (43% somatic, 33% germline),
RAF
alterations (29% somatic), and mismatch repair (14% somatic).

CONCLUSION
Our findings underscore the heterogeneity and aggressive nature of PACC. Despite the improved prognosis for patients with resectable/borderline-resectable disease, OS remains poor, particularly for those with locally advanced or metastatic disease. The identification of actionable molecular targets in a significant proportion of patients highlights the potential for personalized therapeutic approaches. Future research should focus on tailored treatment strategies to exploit these molecular vulnerabilities, which may offer new options for improving outcomes in this rare malignancy.
Reputation mechanisms and cooperative emergence in complex network games: Current status and prospects
Authors: Tang Wei , Yang Hui , Wang Chun 
Published: January 2025

Abstract
This paper comprehensively reviews the research progress on reputation evolution mechanisms within the framework of network-based evolutionary game theory. It first summarizes the typical strategy learning mechanisms used in evolutionary games. Next, it provides an overview of traditional reputation evolution mechanisms and their associated mathematical models, highlighting recent research findings. Furthermore, the paper presents experimental evidence from several key studies, including mechanisms like reputation-based incremental heterogeneity and reputation-based discount accumulation. It identifies the limitations of current research on reputation evolution mechanisms and proposes future research directions. The aim is to empirically verify the role of reputation in promoting cooperative behavior by exploring more accurate reputation evaluation mechanisms and developing reputation evolution models across diverse network structures.
Genotype-Phenotype Correlations in the Hyperparathyroidism-Jaw Tumor Syndrome
Authors: Simonds William F , Li Yulong , Jha Smita 
Published: January 2025

Abstract
Establishing genotype-phenotype correlations in disorders of hereditary endocrine neoplasia is important for clinical screening, genetic counseling, prognostication, surveillance, and surgical strategy, and may also provide clues about disease pathogenesis. Important genotype-phenotype correlations are recognized, for example, in pheochromocytoma/paraganglioma and multiple endocrine neoplasia type 2A. The presence of such correlations has been less clear in other familial endocrine disorders associated with primary hyperparathyroidism including multiple endocrine neoplasia type 1, and the hyperparathyroidism-jaw tumor syndrome (HPT-JT). Characteristic features of HPT-JT, apart from fibro-osseous jaw tumors and uterine lesions, include renal neoplasms, such as Wilms tumor and mixed epithelial and stromal tumor (“renal hamartomas”), and a high incidence of parathyroid cancer. Emerging evidence suggests two different genotype-phenotype correlations in HPT-JT based on the type of variant in the CDC73 tumor suppressor gene. Although multiple CDC73 genotypes can give rise to the Wilms tumor phenotype in HPT-JT, the development of mixed epithelial and stromal tumor of the kidney specifically correlates with the presence of a start-loss variant affecting the initiator methionine codon of parafibromin, the protein product encoded by CDC73. Furthermore, the risk of parathyroid cancer in HPT-JT also appears to correlate with genotype: CDC73 frameshift indel, splice-site, and stop-gain genotypes are associated with a greatly increased risk of parathyroid carcinoma compared to carriers of CDC73 missense and nonframeshift indel variants. The recognition of such genotype-phenotype correlations in HPT-JT may impact genetic counseling, patient care and disease surveillance.
Optogenetic control of cAMP oscillations reveals frequency-selective transcription factor dynamics in Dictyostelium
Authors: Yamashita Kensuke , Shimane Kazuya , Muramoto Tetsuya 
Published: January 2025

ABSTRACT
Oscillatory dynamics and their modulation are crucial for cellular decision-making; however, analysing these dynamics remains challenging. Here, we present a tool that combines the light-activated adenylate cyclase mPAC with the cAMP biosensor Pink Flamindo, enabling precise manipulation and real-time monitoring of cAMP oscillation frequencies in Dictyostelium. High-frequency modulation of cAMP oscillations induced cell aggregation and multicellular formation, even at low cell densities, such as a few dozen cells. At the population level, chemotactic aggregation is driven by modulated frequency signals. Additionally, modulation of cAMP frequency significantly reduced the amplitude of the shuttling behaviour of the transcription factor GtaC, demonstrating low-pass filter characteristics capable of converting subtle oscillation changes, such as from 6 min to 4 min, into gene expression. These findings enhance our understanding of frequency-selective cellular decoding and its role in cellular signalling and development.
A comparison of seasonal flexibility in pectoralis muscle fiber type and enzyme activity in migratory and resident sparrow species
Authors: Lewicki Louisa M. , Zhang Marina , Staples James F. , Guglielmo Christopher G. , Ivy Catherine M. 
Published: January 2025

ABSTRACT
The pectoralis muscle in birds is important for flight and thermogenesis. In migratory songbirds this muscle exhibits seasonal flexibility in size, but whether this flexibility reflects changes in muscle fiber type has not been well documented. We investigated how seasonal changes in photoperiod affected pectoralis muscle fiber type and metabolic enzymes, comparing among three closely related sparrow species: two seasonal migrants and one year-round, temperate climate resident. We quantified fast oxidative glycolytic (FOG) and fast glycolytic (FG) fibers histologically, and measured activities of citrate synthase (CS) and lactate dehydrogenase (LDH) in the pectoralis muscle of the three species that were acclimated to long or short periods of daylight. In all species, FOG was the predominant fiber type, but song sparrows had FG fibers regardless of daylight conditions. By contrast, Lincoln's sparrows incorporated FG fibers only under short-daylight conditions, and house sparrows did not significantly express FG fibers, regardless of daylight length. Both migratory species increased LDH activity in short-daylight conditions but did not alter CS activity. In contrast, resident house sparrows did not alter CS or LDH activity with changes in daylight length. Our findings suggest that the presence of FG fibers is important for seasonal flexibility in LDH activity. Additionally, migratory species exhibited seasonal flexibility in muscle fiber type and enzyme activity, presumably to support migratory flight, while the resident species did not exhibit such seasonal flexibility, suggesting that this consistent phenotype is important year-round, despite changing thermogenic requirements.
Quality of Life and cost of living in lung cancer patients
Authors: Kiranoudi Aggeliki , Kalogianni Antonia , Kapadochos Theodoros , Kouris Ioannis , Douki Stamatina , Kyriakopoulos Antonios , Toylia Georgia 
Published: January 2025

Introduction: Lung cancer accounts for about 34% of cancer deaths in men and 23% in women. Advances in treatment options for lung cancer patients are increasing the survival rate and improving the quality of life.
Aim: To explore the quality of life of lung cancer patients in Greece as well as to estimate the change in their cost of living.
Methods: This is a prospective descriptive observational study. In total, 170 participants were enrolled in the study. Data collection was performed by using a questionnaire of both open-ended and closed-ended questions. Data analysis was performed using SPSS ver. 21.0 (Statistical Package for Social Sciences).
Results: The mean age of patients was 67.4 years, while 72.4% of patients were male. The majority of the patients (71.2%) were retired and 13.6% were employed. The average cost of living due to the disease during the previous semester was €4.518. Patients with lower total cost of living had better general health (p=0,006). Patients who resided with more people, with higher monthly family income and lower total cost of living, had better mental health (0.016, 0.027, 0043, respectively).
Conclusion: The main goal of the therapeutic approach is the quality of life of cancer patient alongside the effectiveness of the treatment. Determining the factors affecting quality of life that the patient considers important is crucial, with cost of living consisting as one of them. Strategies for reducing the cost of living for cancer patients should be considered.
TECENDO BRINCADEIRAS AFRICANAS E AFRO-BRASILEIRAS NA ESCOLA: UMA PROPOSTA PRETAGÓGICA PARA IMPLEMENTAÇÃO DA LEI Nº 10.639/2003
Authors: Silva Samuel Morais , Petit Sandra Haydée 
Published: January 2025

A proposta interventiva é resultado de uma pesquisa de mestrado realizada no Programa de Pós-graduação em Educação, na Universidade Federal do Ceará (UFC), na qual tivemos como objetivo utilizar brincadeiras africanas e afro-brasileiras em aulas de recreação como instrumento facilitador para a implementação da Lei Nº 10.639/03, que reformulou a Lei de Diretrizes e Bases - LDB (9.394/96), com o advento das Diretrizes Curriculares Nacionais para Educação das Relações Étnico-Raciais e para o Ensino de História e Cultura Africana e Afro-brasileira. O lócus de investigação se constitui em uma turma do 4º ano do Ensino Fundamental I, na escola EEIEF 08 de Março. Essa instituição é vinculada à rede municipal de ensino da cidade do Crato, na região do Cariri, Sul do Ceará. Para tanto, realizamos intervenções pedagógicas propositivas e potencializadoras sob aporte da Pretagogia (AUTOR 2, 2015), referencial filosófico-teórico-metodológico inventivo, criativo e artístico, equipado de conhecimento e saber de matriz africana.
A CRIANÇA E SEUS DIREITOS: CENAS DO COTIDIANO DA EDUCAÇÃO INFANTIL EM DIÁLOGO COM OS ESTUDOS DE WALTER BENJAMIN
Authors: da Costa Abreu Alessandra , Araújo Mairce , Bampi Maria 
Published: January 2025

O presente artigo tem como objetivo discutir e defender o lugar de autoria das crianças da Educação Infantil, reconhecendo-as como sujeitos histórico-culturais, atores sociais, protagonistas e produtoras de culturas. O texto se desenha a partir dos estudos de Walter Benjamin que apontam que o modo como as crianças leem e interpretam o mundo são pistas para aprender com elas. Para tal, fundamentadas no diálogo com o autor, trazemos duas situações do cotidiano que instigam reflexões sobre como algumas estratégias utilizadas pelas crianças transgridem modos de aprenderensinar, ainda hegemônicos no cotidiano escolar, que nos levam a questionar o respeito aos direitos das crianças. Para tais reflexões destacamos a contribuição da legislação para o currículo da educação infantil, por meio da Constituição Federal de 88 e as Diretrizes Curriculares Nacionais para a Educação Infantil que garante vários direitos educacionais às crianças. Por fim, problematizamos o quanto a escola precisa se repensar para ser um local em que o ato dialógico aprenderensinar aconteça de uma forma horizontalizada, em que docentes e crianças aprendam e ensinem concomitantemente, como já nos orientava Paulo Freire, e romper com uma concepção pedagógica pautada pela reprodução de modelos pré-estabelecidos, vivências repetitivas que não garantem o lugar de autoria das crianças.
Ampliación de los BRICS: Transición Energética y Diplomacia Económica de China | BRICS enlargement: energy transition and Chinese economic diplomacy
Authors: Busilli Virginia Soledad , Aguirre Franco Luciano , Fuma Maitén de los Milagros 
Published: January 2025

El artículo analiza la ampliación de los BRICS en 2023 en el marco de la diplomacia económica china, contemplando su objetivo de constituir un liderazgo en la transición energética global. Recientemente, los BRICS se han convertido en un espacio relevante para la gobernanza global hacia el desarrollo verde. La incorporación de Arabia Saudita, Egipto, Emiratos Árabes Unidos, Etiopía e Irán es afín a los lineamientos energéticos de política exterior de Xi Jinping. El trabajo explora la transición energética como eje de la estrategia externa de China y su articulación con las directrices de BRICS. Para ello, analiza sus vínculos bilaterales con los nuevos miembros, incluyendo asociaciones estratégicas integrales, lazos comerciales e iniciativas de inversión. Se argumenta que la jerarquización de estos socios en la diplomacia china ya se observa en el plano bilateral, y que sus ingresos a BRICS promueven el interés chino en un liderazgo multilateral energético.
A Literatura Surda no processo de Letramento Literário: leitura e interpretação das obras Patinho Surdo e Tibi e Joca na sala de aula
Authors: Ramos dos Santos Miriam 
Published: January 2025

Neste artigo, visamos analisar o uso da Literatura Surda na escola como uma proposta de Letramento Literário no Ensino Fundamental. Para isso, propomos como obras a serem trabalhadas em sala de aula os livros Patinho Surdo (ROSA; KARNOPP, 2005) e Tibi e Joca (BISOL, 2001). Trata-se de obras de destaque na Literatura Surda brasileira para o público infantil e juvenil. Nelas, surdos são representados não como deficientes, mas sim como sendo diferentes no âmbito linguístico, identitário e cultural. No que tange ao Letramento Literário de crianças e jovens, partimos dos pressupostos teóricos de Soares (2010), Cosson (2014) Coelho (2000), Amarilha (2009) entre outros. Com relação ao surdo, à língua de sinais e à Literatura Surda, recorremos às teorias de Quadros (1997), Karnopp (2006, 2010), Campos e Stumpf (2012), Perlin (2013) etc. O trabalho com obras literárias que trazem em seu âmago o protagonismo surdo, as representações de vivências de surdos, bem como suas diferenças linguísticas, identitárias e culturais, podem levar os discentes a um Letramento Literário que envolva a inclusão dessas minorias. As atividades com a Literatura Surda na escola abrem caminho para o dizer do surdo sobre si, ter visibilidade e representatividade literária e social.
Gastrointestinal bleeding due to small bowel metastasis from lung adenocarcinoma: A case report
Authors: Yuan Tian-Yuan , Chen Ying-Xin , Zhao Yan-Ge , Wang Bing , Wang Shao-Xuan 
Published: January 2025

BACKGROUND
Lung cancer is the most prevalent malignant tumor in human body, and is characterized by a high level of malignancy. The most common metastatic sites include the liver, bone, brain, and adrenal gland, while lung cancer resulting in gastrointestinal tract metastasis is uncommon.
CASE SUMMARY
A 74-years-old man with lung cancer was hospitalized owing to blood in the stool, The cause was identified as metastasis to the small intestine, and the patient subsequently underwent radical resection of the small intestine tumor. Currently, the overall condition of the patient is good, and undergoing combined chemotherapy.
CONCLUSION
Early intervention in patients with metastatic tumors can significantly improve prognosis.