bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance
Authors: Wang Li‐Min , Wang Pingyuan , Chen Xiao‐Min , Yang Hui , Song Shan‐Shan , Song Zilan , Jia Li , Chen Hua‐Dong , Bao Xu‐Bin , Guo Ne , Huan Xia‐Juan , Xi Yong , Shen Yan‐Yan , Yang Xin‐Ying , Su Yi , Sun Yi‐Ming , Gao Ying‐Lei , Chen Yi , Ding Jian , Lang Jing‐Yu , Miao Ze‐Hong , Zhang Ao , He Jin‐Xue 
Published: January 2023

AbstractPoly‐ADP‐ribose polymerase (PARP) inhibitors (PARPi) have shown great promise for treating BRCA‐deficient tumors. However, over 40% of BRCA‐deficient patients fail to respond to PARPi. Here, we report that thioparib, a next‐generation PARPi with high affinity against multiple PARPs, including PARP1, PARP2, and PARP7, displays high antitumor activities against PARPi‐sensitive and ‐resistant cells with homologous recombination (HR) deficiency both in vitro and in vivo. Thioparib treatment elicited PARP1‐dependent DNA damage and replication stress, causing S‐phase arrest and apoptosis. Conversely, thioparib strongly inhibited HR‐mediated DNA repair while increasing RAD51 foci formation. Notably, the on‐target inhibition of PARP7 by thioparib‐activated STING/TBK1‐dependent phosphorylation of STAT1, triggered a strong induction of type I interferons (IFNs), and resulted in tumor growth retardation in an immunocompetent mouse model. However, the inhibitory effect of thioparib on tumor growth was more pronounced in PARP1 knockout mice, suggesting that a specific PARP7 inhibitor, rather than a pan inhibitor such as thioparib, would be more relevant for clinical applications. Finally, genome‐scale CRISPR screening identified PARP1 and MCRS1 as genes capable of modulating thioparib sensitivity. Taken together, thioparib, a next‐generation PARPi acting on both DNA damage response and antitumor immunity, serves as a therapeutic potential for treating hyperactive HR tumors, including those resistant to earlier‐generation PARPi.
Analisis Wacana Kritis Berita Pemindahan Ibu Kota Negara Pada Youtube TvOneNews
Authors: Lbs M Akbar Hasyim 
Published: January 2023

AbstrakTulisan ini bermaksud untuk membongkar wacana sosial politik secara kritis dengan menganalisis berita pemindahan ibu kota negara di media sosial youtube tvOneNews. Kajian ini menggunakan paradigma kritis dengan pendekatan kualitatif dan menggunakan metode analisis wacana kritis model Teun A. van Dijk. Dalam mengumpulkan data, teknik yang digunakan adalah studi dokumentasi dan telaah isi. Hasil yang diperoleh, dalam dimensi teks berita ini secara umum menegaskan tema pemindahan ibu kota negara yang dibingkai dari sudut pandang sosial ekonomi. Dalam dimensi kognisi sosial tvOneNews berusaha untuk mengkritisi secara tegas langkah-langkah yang diambil pemerintah dalam pemindahan ibu kota negara. Sementara terkait konteks sosial, masyarakat Indonesia sedang berada pada situasi polemik yang mengakibatkan terbelahnya pandangan masyarakat menjadi kelompok pro dan kontra. Penulis melihat kajian semacam ini dapat dikembangkan lebih jauh dengan pendekatan atau model analisis yang berbeda mengingat isu ini akan terus berlanjut dan semakin hangat kedepannya. Abstract This paper intends to critically dismantle socio-political discourse by analyzing the news of the relocation of the nation's capital on the social media youtube tvOneNews.. This study uses a critical paradigm with a qualitative approach and uses the critical discourse analysis method of the Teun A. van Dijk model. In collecting data, the technique used is documentation study and content review. The results obtained, in the dimensions of the news text, generally emphasize the theme of moving the national capital which is framed from a socio-economic point of view. In the dimension of social cognition, tvOneNews tries to strictly criticize the steps taken by the government in relocating the nation's capital city. Meanwhile, related to the social context, the Indonesian people are currently in a polemic situation which has resulted in the splitting of public views into pro and con groups. The author sees that this kind of study can be developed further with a different approach or model of analysis considering that this issue will continue and be warmer in the future.
The Effect of Employee Agility and Self-Efficacy on Innovative Behavior at Work
Authors: Dzimidienė Agnė , Bagdžiūnienė Dalia 
Published: January 2023

In order for organizations to remain competitive and successful in the contemporary business environment, one of the fundamental prerequisites is innovative behavior of employes. Therefore, research analyzing the organizational and personal factors of this behavior is relevant, in which increasing attention is paid to the agility of employees. In general, agility can be described as a person’s ability to adapt quickly and efficiently to normal or new work situations, accept changes and respond appropriately to them. The study aimed to determine the relationship between employees agility, self-efficacy, and innovative behavior in the organization and to evaluate the mediating role of self-efficacy for the relations between agility and innovative behavior. The cross-sectional survey was conducted in the sample of 172 employees. 78% of them were women, the average age of the participants was 33.8 years. Scales measuring employee agility, innovative behavior and self-efficacy were applied in the study. For this study, a Lithuanian employee agility scale consisting of twenty items was prepared. The results were processed using correlational, regression, and mediation analysis. Main results: firstly, more expressed employee agility and self-efficacy predicts their higher involvement in innovative behavior, and secondly, self-efficacy acts as a mediator for the relationship between agility and innovative behavior. The importance of the employee’s personal characteristics – agility and self-efficacy – in predicting innovative behavior was confirmed, and the role of self-efficacy as a mediator for the relationship between agility and innovative behavior was revealed. Theoretical and practical implications of the study results are discussed.
Variation in Emergency Department Use of Racemic Epinephrine and Associated Outcomes for Croup
Authors: Walsh Patrick S. , Zhang Yin , Lipshaw Matthew J. 
Published: January 2023

OBJECTIVES
Racemic epinephrine (RE) is commonly administered for croup in the emergency department (ED). Our objectives were to examine variation in RE use between EDs, to determine whether ED variation in RE use is associated with hospital or patient factors, and to evaluate the associations between the rates of hospital-specific ED RE use and patient outcomes.

METHODS
We performed a retrospective cohort study using the Pediatric Heath Information System of children aged 3 months to 10 years with croup in the ED. We used mixed-effects regression to calculate risk-standardized proportions of patients receiving RE in each ED and to analyze the relationship between risk-standardized institutional RE use and individual patient odds of hospital admission, ICU admission, and ED revisits.

RESULTS
We analyzed 231 683 patient visits from 39 hospitals. ED administration of RE varied from 14% to 48% of visits (median, 24.5%; interquartile range, 20.0%–27.8%). A total of 8.6% of patients were hospitalized and 1% were admitted to the ICU. After standardizing for case mix and site effects, increasing ED use of RE per site was associated with increasing patient odds of hospital admission (odds ratio [OR], 1.39–95%; confidence interval [CI], 1.01–1.91), but not ICU admission (OR, 1.39; 95% CI, 0.99–1.97) or ED revisit (OR, 1.00; 95% CI, 0.92–1.09).

CONCLUSIONS
In this large, observational study, RE administration varied widely across EDs. Increased RE use by site was associated with increased odds of hospital admission for individual patients when controlling for patient factors. These results suggest further standardization of RE use in children with croup is warranted.
Near-infrared spectroscopy of Chinese soy sauce for quality evaluation
Authors: Chen Xiaoqian , Li Chuanwei , Liu Xiaofang , Su Yu , Sun Ziang , Yuan Lei , Wang Shuo 
Published: January 2023

The feasibility of near-infrared (NIR) spectroscopy and partial least-squares regression (PLSR) was investigated for rapid prediction of the quality of Chinese soy sauce. Twenty-four soy sauce samples from eight common brands available in China were analyzed for the contents of various components that may affect the quality of soy sauce. Sensory evaluation was also conducted to determine the relationship between components and the sensory quality of soy sauce. Subsequently, NIR spectra (400–2500 nm) of the samples were obtained, and the raw spectra were subjected to different pretreatment methods. PLSR was performed on the raw and treated spectra to construct models using a calibration set. The performance of models was evaluated by comparing the determination coefficient of prediction (R2P) and root-mean-square error of prediction (RMSEP). The results showed that the models constructed using the moisture content (R2P of 0.825 and RMSEP of 1.73), amino acid nitrogen content (R2P of 0.785 and RMSEP of 0.071), and taste scores (R2P of 0.733 and RMSEP of 11.93) performed well, and the interactions between amino acid nitrogen content and taste of soy sauce were clarified. This study demonstrates that NIR spectroscopy can be used as a valid alternative method for rapid prediction of the sensory quality of soy sauce during processing.
Moulded RSA and DES (MRDES) Algorithm for Data Security
Authors: Sabeena S. Jenifa , Vijila S. Antelin 
Published: January 2023

In the recent days transmission of large amount of data through online is very prominent. Security is necessary while transmitting large amount of data. Since the data may belost or hacked at some point of transmission. Normally there are three important factors interms of security. They are key generation, encryption and decryption. There are two types of crypto system namely symmetric cryptosystem and asymmetric cryptosystem. There are many publicly available cryptosystems. It may lead the intruders to view the original message sent by the sender using all the possible keys. In order to provide secure transmission of data, a novel encryption algorithm is proposed by analyzing all the existing algorithms. The existing Rivest–Shamir–Adleman (RSA) and Data encryption standard (DES) algorithm are moulded together rto produce the proposed MRDES encryption algorithm. The performance of the proposed Moulded RSA and DES is higher than the existing encryption algorithms and provides higher data security.
User Selection and Pairing for Future Power Domain Non-Orthogonal Multiple Access (PD-NOMA) using Deep Learning Techniques
Authors: Kavitha G , Deny J 
Published: January 2023

The next-generation wireless networks and communications such as 5G/6G offers various benefits such as low latency, high data rates, and improvement in user numbers with increased base station capacity and quality of service. These advantages are obtained from the increasing receiver complexity through the non-orthogonal multiple access (NOMA) of users. It is the promising radio access approach used to enhance next-generation wireless communications. Among the techniques of NOMA such as power and code domain, this paper concentrates on power domain NOMA. The user in the network for transmission is selected using a deep learning approach called deep neural network (DNN). This user selection results are the training data and the loss function is modified for the selection of users that could meet the constraint the selected user cannot be in both strong and weak groups. The user aggregation/user pairing among the sub-channels is performed through the exhaustive analysis using particle swarm optimization (PSO). The usage of DNN-PSO enables the transmitter and required minimum uplink and downlink transmitting power and guaranteed for Quality of Service of each user. The simulation and comprehensive statistical evaluation are performed with the comparative analysis of energy efficiency and maximum achievable rate with the given spectrum efficiency (SE) of PD-NOMA. The proposed model ensures reduced latency, increased throughput, less energy, achievable data rate, user fairness and increased reliability and quality of service.
Southwest Australia Seismic Network (SWAN): Recording Earthquakes in Australia’s Most Active Seismic Zone
Authors: Miller Meghan S. , Pickle Robert , Murdie Ruth , Yuan Huaiyu , Allen Trevor I. , Gessner Klaus , Kennett Brain L. N. , Whitney Justin 
Published: January 2023

AbstractThe geological structure of southwest Australia comprises a rich, complex record of Precambrian cratonization and Phanerozoic continental breakup. Despite the stable continental cratonic geologic history, over the past five decades the southwest of Western Australia has been the most seismically active region in continental Australia, though the reason for this activity is not yet well understood. The Southwest Australia Seismic Network (SWAN) is a temporary broadband network of 27 stations that was designed to both record local earthquakes for seismic hazard applications and provide the opportunity to dramatically improve the rendering of 3D seismic structure in the crust and mantle lithosphere. Such seismic data are essential for better characterization of the location, depth, and attenuation of the regional earthquakes, and hence understanding of earthquake hazard. During the deployment of these 27 broadband instruments, a significant earthquake swarm occurred that included three earthquakes of local magnitude 4.0 and larger, and the network was supplemented by an additional six short-term nodal seismometers at 10 separate sites in early 2022, as a rapid deployment to monitor this swarm activity. The SWAN experiment has been continuously recording since late 2020 and will continue into 2023. These data are archived at the International Federation of Digital Seismograph Networks (FDSN) - recognized Australian Passive Seismic (AusPass) Data center under network code 2P and will be publicly available in 2025.
Trust Between Physicians and Family Caregivers: Qualitative Insights from Three Family‐Centered Academic Medical Centers
Authors: Rao Ruchira , Raj Minakshi 
Published: January 2023

AbstractFamily caregivers increasingly support health care tasks but are not meaningfully integrated into the health care setting in consistent or standard way. Previous literature has established the importance of trust in patient‐clinician relationships; yet, little is known about family caregiver‐clinician trust, and further, how and when to integrate family caregivers into health care teams so they can better support their relative. This study examined a) how physicians assess and perceive trust with family caregivers, b) the role of culture in trust dynamics, and c) facilitators and barriers to integrating caregivers into health care teams. We conducted twenty qualitative interviews with physicians in geriatrics (n=9) and oncology/hematology (n=11) between January–March 2021. Physicians assess caregivers' competence, reliability/dependability, and fidelity. They assess caregivers' engagement (e.g., asking questions, verbal and non‐verbal cues) to determine whether caregivers trust them. Physicians in our study trust other physicians more than caregivers in certain situations (e.g., for objective information, data) while they trust caregivers more than other physicians for information that requires familiarity and time with the patient (e.g., observations in the home environment). When supporting patients from diverse cultural backgrounds, physicians often rely upon caregivers to provide contextual information about relevant cultural norms. Integrating caregivers into the care team early—when the patient‐caregiver relationship is strong—can be critical to providing effective patient care. Technology can facilitate the trust‐building process to further support caregiver integration. Building trust‐driven partnerships between physicians and family caregivers could be critical for effective communication of important information to support patient care. Guidelines and policies related to telehealth, discussions between physicians and caregivers, tools to screen caregivers for skills and caregiver burden, and reimbursements for partnering with caregivers are important priorities for supporting caregivers and patient care.
A HELYESÍRÁS ELSAJÁTÍTÁSA ÉS A KIEJTÉS SZERINTI ÍRÁSMÓD PROBLÉMÁI
Authors: KOZMÁCS István , VANČO Ildikó 
Published: January 2023

A nyelvek ortográfiája a felszíni (shallow) vagy mély (deep) kategóriák mentén helyezhető el (Frost–Katz–Bentin 1987). A magyar helyesírás egyik alapelve a kiejtés szerinti írásmód, így úgy tűnhet, a helyes írás nem okoz különösebb problémát a tanulóknak. A mély kategóriába tartozik például, hogy az értelmileg összetartozó elemeket, mint az igekötők és segédigék, egy prozódiai egységnek ejtjük, míg az írásban különírjuk őket. A helyesírás tanításakor az a cél, hogy a tanuló a mély helyesírású elemeket is hibátlanul rögzítse és a külső algoritmus szintjéről – a tudatosítás szintjéről – a belső algoritmus szintjére – készségszintre – jusson el. Jelen írás egy, az általános iskolák felső tagozatára járó tanulók számára évente megrendezett országos helyesírási verseny 5. osztályos tanulói (N = 3340) alapján vizsgálja meg, hogy mennyire eredményesek a tanulók egyes mély helyesírási struktúrák elsajátításában.
CSEKES BÉLA, AZ AMERIKÁBÓL HAZATÉRT FELVIDÉKI LELKÉSZ
Authors: PETHEŐ Attila 
Published: January 2023

Csekes Béla teremtő falusi lelkészként ápolt kiváló külföldi kapcsolatokat a sérelmeket szenvedő lelkésztársai érdekében. Több nyelven beszélt. Járt Amerikában, Kanadában, szolgált
Óbecsén, Magyarországon, majd hazatért szűkebb pátriájába. Dolgozatomban az életéről eddig feltáratlan újdonságokkal szolgálok. A célom, hogy a köztudatba beépítsem életművét, ismertté tegyem a Református Világszemle című, általa kiadott folyóiratot, hiszen ebből kiváló képet kaphatunk nem csupán a tengerentúli, de a felvidékin túl az erdélyi és a délvidéki református egyház 1930-as évekbeli helyzetéről is. A Jugoszláv Királyságban élő reformátusok helyzetéről megsüvegelendő bőséggel számol be a Református Világszemle. A lelkész életéről a szapi és a dunaradványi református egyházközségek irattáraiban, a Református Világszemle lapszámaiban, a prágai Českobratská cirkev evanjelická (Cseh Testvérek Egyháza) levéltárában, a Komáromban található Szlovákiai Református Keresztyén Egyház Zsinati Irodája mellett működő Központi Levéltárban és a pápai Dunántúli Református Egyházkerület Levéltárában kutattam.
Effect of Tempe Yeast Concentration and Fermentation Time on the Functional Charaktersitics of Fermented Peanut Flour
Authors: Martina Salma , Erminawati Erminawati , Naufalin Rifda 
Published: January 2023

Peanuts are one type of nuts that are quite a lot in Indonesia. Peanuts processing in Indonesia is still very limited. It is necessary to diversify the processing of peanuts into other food products. One of the efforts to diversify the peanuts process is to process them into flour. Peanuts have a weakness, namely, peanuts contain compounds of anti-nutritional substances which are mostly dominated by phytic acid and the presence of an unpleasant odor. This weakness can be overcome by the fermentation process. tempe is one of the processed products fermented in beans. The purpose of this study was to determine the functional characteristics of fermented peanut flour with variation in yeast concentration and fermentation time; and the best combination of the treatments. This study used a completely randomized design (CRD). The factors tested were the concentration of tempe yeast (3, 5 and 7%) and length of fermentation (24, 28, 32 dan 36 hours). The result of the study showed that all treatments had a significant effect on the functional characteristics of fermented peanut flour. The result shows that fermentation treatment with variations used increase the levels of water absorption capacity, solubility in water, total phenol, and antioxidant activity; but decrease the levels of oil absorption capacity and emulsion capacity. Fermented peanut flour with the best functional properties was obtained at 7% yeast concentration and 36 hours of fermentation (R3F4) treatments.
ANALISIS PENATALAKSANAAN GIZI BALITA STUNTING PADA MASA PANDEMI COVID-19 DENGAN METODE ANALYTIC HIERARCHY PROCESS(AHP) DI PUSKESMAS MUARA BASUNG
Authors: Sumengen Sumengen , Melati Rima , Hartono Budi , Mahyuddin Meriwati , Yunita Jasrida 
Published: January 2023

ABSTRACT
Nutritional status in children under five is very important, if malnutrition occurs and if not treated immediately it will reduce the quality of human resources resulting in physical disorders, impaired intelligence and productivity. The COVID-19 pandemic increases the risk of an increase in the prevalence of stunting. The purpose of this study was to analyze the nutritional management of stunting toddlers during the COVID-19 pandemic using the Analytic Hierarchy Process (AHP) method at the X Health centre, Bengkalis Regency based on input, process and output components. Method: This study used a qualitative approach using the analytic hierarchy process method. Data collection methods were carried out by in-depth interviews and observations to 15 informants, consisting of the administrative head of the Health Centre, nutrition officers, MCH coordinator midwife, village midwife, posyandu cadres and mothers of stunting toddlers. Result: showed that at the input stage, health workers such as TPG and village midwives had met the competency requirements, there were no special appointments for stunting cadres and specific technical guidelines for stunting management, as well as the lack of infrastructure for monitoring growth and development in Posyandu. Implemented properly include antenatal care, supplementary feeding, vitamin A administration, the coverage of which is still low is exclusive breastfeeding and visits to Posyandu. In the output element, the prevalence of stunting at the X Health Center in 2020 reached 15.02%Keyword : AHP, Management of stunting, Covid 19
TWITTER SENTIMENT ANALYSIS PEDULILINDUNGI APPLICATION USING NAÏVE BAYES AND SUPPORT VECTOR MACHINE
Authors: Yunanto Indra , Yulianto Sri 
Published: January 2023

The PeduliLindungi application is an application launched by the government during the COVID-19 pandemic, with the aim of helping government agencies carry out digital tracking to monitor the public, as an effort to prevent the spread of the Corona virus. Many people express their opinions on the PeduliLindung application on social media, one of which is through Twitter. To improve the performance of the application, of course, need input or complaints from users, opinions from the public on Twitter about the PeduliLindungi application can be input to improve or improve the performance of the application. Sentiment analysis is carried out to see how the public's sentiment towards the PeduliLindung application is, and these sentiments will be categorized into positive sentiment and negative sentiment, this sentiment can later be used as evaluation material for application development. This study aims to see and compare the accuracy of two classification methods, Naïve Bayes and Support Vector Machine in the classification process of sentiment analysis. The data used are 4636 tweets with the keyword " PeduliLindungi". The data obtained then goes to the pre-processing stage before going to the classification stage. The results obtained after classifying using the Naïve Bayes method and the Support Vector Machine show that the Support Vector Machine method has a higher accuracy of 91%, while the Naïve Bayes method has an accuracy of 90%.