bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nurse‐led supportive Coordinated Transitional Care (CTraC) program improves care for veterans with serious illness
Authors: Madrigal Caroline , Radlicz Christopher , Hayes Barbara , Gosian Jeffrey , Jensen Laury L. , Skarf Lara M. , Hawley Chelsea E. , Moye Jennifer , Kind Amy J. , Paik Julie M. , Driver Jane A. 
Published: July 2023

AbstractBackgroundThe Coordinated Transitional Care (CTraC) program is a telephone‐based, nurse‐driven program shown to decrease readmissions. The aim of this project was to implement and evaluate an adapted version of CTraC, Supportive CTraC, to improve the quality of transitional and end‐of‐life care for veterans with serious illness.MethodsWe used the Replicating Effective Programs framework to guide adaptation and implementation. An RN nurse case manager (NCM) with experience in geriatrics and palliative care worked closely with inpatient and outpatient care teams to coordinate care. Eligible patients had a life‐limiting diagnosis with substantial functional impairment and were not enrolled in hospice. The NCM identified veterans at VA Boston Healthcare System during an acute admission and delivered a protocolized intervention to define care needs and preferences, align care with patient values, optimize discharge plans, and provide ongoing, intensive phone‐based case management. To evaluate efficacy, we matched each Supportive CTraC enrollee 1:1 to a contemporary comparison subject by age, risk of death or hospitalization, and discharge diagnosis. We used Kaplan–Meier plots and Cox‐Proportional Hazards models to evaluate outcomes. Outcomes included palliative and hospice care use, acute care use, Massachusetts Medical Orders for Life Sustaining Treatment documentation, and survival.ResultsThe NCM enrolled 104 veterans with high protocol fidelity. Over 1.5 years of follow‐up, Supportive CTraC enrollees were 61% more likely to enroll in hospice than the comparison group (n = 57 vs. 39; HR = 1.61; 95% CI = 1.07–2.43). While overall acute care use was similar between groups, Supportive CTraC patients had fewer ICU admissions (n = 36 vs. 53; p = 0.005), were more likely to die in hospice (53 vs. 34; p = 0.008), and twice as likely to die at home with hospice (32.0 vs. 15.5; p = 0.02). There was no difference in survival between groups.ConclusionsA nurse‐driven transitional care program for veterans with serious illness is feasible and effective at improving end‐of‐life outcomes.
An online survey to understand the needs of caregivers of family members with 22q11 deletion syndrome
Authors: Cosman T. , Finless A. , Rideout A. L. , Lingley‐Pottie P. , Palmer L. D. , Shugar A. , McDonald‐McGinn D. M. , Swillen A. , McGrath P. J. , Bassett A. S. , Cytrynbaum C. , Orr M. , Meier S. 
Published: July 2023

AbstractBackgroundMost individuals with 22q11.2 deletion syndrome (22q11DS) have multi‐system and lifelong needs requiring substantial support. Their primary caregivers are usually family members who dedicate lifelong time and effort to their role. The pressures of their roles can negatively impact caregivers' psychosocial well‐being, suggesting a need for additional support for this community who currently have no specialised interventions available.MethodThis online study surveyed 103 caregivers of family members with 22q11DS to determine the barriers to accessing support that they faced, the kind of support they would value and whether an online intervention could meet their needs.ResultsThe caregivers indicated that a brief online intervention focused on teaching practical skills and connecting them with a peer network of support would be most valuable.ConclusionsFuture studies are planned that will build on these results by designing and testing online interventions tailored to this community.
Phenotypic features of RETREG1‐related hereditary sensory autonomic neuropathy
Authors: Çakar Arman , Bagırova Gulandam , Durmuş Hacer , Uyguner Oya , Parman Yeşim 
Published: July 2023

AbstractBackground and AimsHomozygous loss‐of‐function mutations in the RETREG1 gene result in Hereditary Sensory Autonomic Neuropathy Type 2B. Clinical features include pain loss, autonomic disturbances, and upper motor neuron features.MethodsWe evaluated the clinical and genetic features of seven patients from four families with RETREG1 variants.ResultsFive patients were male. The median age of disease onset was 7.00 ± 2.81 (between 2 and 10 years). A combination of painless wounds, trophic changes, and foot ulcerations was the presenting symptom in five patients and walking difficulties in two. Motor symptoms were present in five patients. In a median disease duration of 30.00 ± 12.88 years, five patients had osteomyelitis, and three had toe amputations. A history of renal disease was present in one family. In another family, three affected siblings had short stature and a history of delayed puberty. Although sensory signs predominated the clinical findings, various degrees of motor signs such as muscle weakness, spasticity, and brisk tendon reflexes were noted in all patients. Nerve conduction studies showed axonal sensory‐motor neuropathy in five patients and sensory neuropathy in two. Three pathogenic variants were identified in the RETREG1 gene. Two unrelated patients had a homozygous c.433C > T/p.(Gln145*), one a homozygous c.826delA/p.(Ser276Valfs*8), and the last had a novel homozygous c.102delC/p.(Ala35Glnfs*349) variants.InterpretationIn our study, all patients showed signs and symptoms consistent with pain insensitivity. Although shadowed by sensory symptoms, motor signs were noted in our patients. Further studies are necessary to clarify the causal relationship between extra‐neurological features and RETREG1 mutations.
Brush border enzyme hydrolysis and glycaemic effects of isomaltulose compared to other saccharides in dogs
Authors: Corbee Ronald J. , Mes Jurriaan J. , de Jong Govardus A. H. , van den Dool Ronald T. M. , Neumer Franka , Theis Stephan , Bosch Guido 
Published: July 2023

AbstractDigestible carbohydrates differ in glycaemic response, therewith having the potential to influence metabolic conditions such as insulin resistance and diabetes mellitus. Isomaltulose has been proven to lower the glycaemic response in humans, which to date has not been studied in dogs. Therefore, the aim of the present study was to characterise the digestibility, as well as the physiological effects of isomaltulose in dogs, in comparison to other saccharides. To this end, three studies were performed. Study 1 was an in vitro study, evaluating the small intestinal hydrolysis of isomaltulose compared to other relevant carbohydrate sources. Three of these saccharides, having close and low‐moderate degrees of hydrolysis by brush border enzymes, were also evaluated in vivo for their glycaemic effects by measuring plasma levels of glucose, insulin and glucagon‐like peptide 1 (GLP‐1) 0‐180 min after administration of a single dosage after an overnight fast (i.e., isomaltulose, sucrose and maltodextrin in a 3 × 3 Latin‐square design, in 9 dogs, Study 2). To understand if digestive enzymes, underlying glycaemic responses for isomaltulose and sucrose can be upregulated, we exposed dogs to these saccharides for 2 weeks and repeated the measurements after an overnight fast in 18 dogs (Study 3). Isomaltulose was hydrolysed by intestinal enzyme preparation from all three dogs, but the degrading activity was low (e.g., 3.95 ± 1.03 times lower vs. sucrose), indicating a slower rate of hydrolysis. Isomaltulose had a low glycaemic response, in line with in vitro data. In vitro hydrolysis of sucrose was comparable or even higher than maltodextrin in contrast to the more pronounced glycaemic response to maltodextrin observed in vivo. The numerically higher blood glucose response to sucrose after continuous consumption, might indicate an adaptive response. In conclusion, the current work provides valuable insights into the digestion physiology of various saccharides in dogs. Further investigations on related benefits are thus warranted.
The interplay of financial toxicity, health care team communication, and psychosocial well‐being among rural cancer patients and survivors
Authors: Miller Melissa F. , Olson Julie S. , Doughtie Kara , Zaleta Alexandra K. , Rogers Kimberly P. 
Published: July 2023

AbstractBackgroundFinancial toxicity contributes to psychosocial distress among cancer patients and survivors. Yet, contextual factors unique to rural settings affect patient experiences, and a deeper understanding is needed of the interplay between financial toxicity and health care team communication and its association with psychosocial well‐being among rural oncology patients.PurposeWe examined associations between financial toxicity and psychosocial well‐being among rural cancer patients, exploring variability in these linkages by health care team communication.MethodsUsing data from 273 rural cancer patients who participated in Cancer Support Community's Cancer Experience Registry, we estimated multivariable regression models predicting depression, anxiety, and social function by financial toxicity, health care team communication, and the interplay between them.ResultsWe demonstrate robust associations between financial toxicity and psychosocial outcomes among our sample of rural cancer patients and survivors. As financial toxicity increased, symptoms of depression and anxiety increased. Further, financial toxicity was linked with decreasing social function. Having health care team conversations about treatment costs and distress‐related care reduced the negative impact of financial toxicity on depressive symptoms and social function, respectively, in rural cancer patients at greatest risk for financial burden.ConclusionsFinancial toxicity and psychosocial well‐being are strongly linked, and these associations were confirmed in a rural sample. A theorized buffer to the detrimental impacts of financial toxicity—health care team communication—played a role in moderating these associations. Our findings suggest that health care providers in rural oncology settings may benefit from tools and resources to bolster communication with patients about costs, financial distress, and coordination of care.
Effect of human periodontal ligament stem cell‐derived exosomes on cementoblast activity
Authors: Li Shengnan , Guan Xiuchen , Yu Wenting , Zhao Zeqing , Sun Yaxi , Bai Yuxing 
Published: July 2023

AbstractObjectivesExosomes derived from stem cells are a potential cell‐free tool for tissue regeneration with therapeutic potential. However, its application in cementum repair is unclear. This study aimed to investigate the effect of human periodontal ligament stem cell‐derived exosomes on the biological activity of cementoblasts, the main effector cells in cementum synthesis.Materials and MethodsOCCM‐30 cementoblasts were cultured with various human periodontal ligament stem cell‐derived exosome concentrations. OCCM‐30 cells proliferation, migration, and cementogenic mineralization were examined, along with the gene and protein expression of factors associated with cementoblastic mineralization.ResultsExosomal promoted the migration, proliferation, and mineralization of OCCM‐30 cells. The exosome‐treated group significantly increased the expression of cementogenic‐related genes and proteins. Furthermore, the expression of p‐PI3K and p‐AKT was enhanced by exosome administration. Treatment with a PI3K/AKT inhibitor markedly attenuated the gene and protein expression of cementoblastic factors, and this effect was partially reversed by exosome administration.ConclusionsHuman periodontal ligament stem cell‐derived exosomes can promote the activity of cementoblasts via the PI3K/AKT signaling pathway, providing a scientific basis for promoting the repair process in orthodontically induced inflammatory root resorption.
IL17RB expression is associated with malignant cancer behaviors and poor prognosis in oral cancer
Authors: Yuan Shyng‐Shiou F. , Su Chang‐Wei , Chan Leong‐Perng , Nguyen Hieu D. H. , Chen Yuk‐Kwan , Du Je‐Kang , Cheng Kuang‐Hung , Wang Yen‐Yun 
Published: July 2023

AbstractObjectivesPreviously, we demonstrated that IL17RB plays an essential role in lung cancer progression. This study aimed to determine whether IL17RB correlates with oral cancer and promotes oral cancer progression.Subjects and MethodsIL17RB expression in oral cancer tissues and normal tissues was determined by immunohistochemistry staining, while the association of IL17RB expression with the clinicopathological characteristics of oral squamous cell carcinoma (OSCC) patients was analyzed and its correlation with progression‐free survival and response to radiotherapy and chemotherapy in OSCC patients was also explored. Western blotting was performed to investigate the expression of IL17RB in various OSCC cell lines; moreover, transwell assay was performed to evaluate the effect of IL17RB expression on cell migration ability.ResultsIn this study, we found that IL17RB was expressed higher in OSCC tissues compared to normal oral mucosa tissues and its expression was positively correlated with tumor size, lymph node metastasis, advanced cancer stage, and poor prognosis. In vitro study showed that IL17RB expression in OSCC cell lines as determined by Western blotting, was positively correlated with their migration ability.ConclusionClinical and in vitro studies suggest that IL17RB might serve as an independent risk factor and a therapeutic target for oral cancer.
Improving measurement and prediction in personnel selection through the application of machine learning
Authors: Koenig Nick , Tonidandel Scott , Thompson Isaac , Albritton Betsy , Koohifar Farshad , Yankov Georgi , Speer Andrew , Hardy Jay H. , Gibson Carter , Frost Chris , Liu Mengqiao , McNeney Denver , Capman John , Lowery Shane , Kitching Matthew , Nimbkar Anjali , Boyce Anthony , Sun Tianjun , Guo Feng , Min Hanyi , Zhang Bo , Lebanoff Logan , Phillips Henry , Newton Charles 
Published: July 2023

AbstractMachine learning (ML) is being widely adopted by organizations to assist in selecting personnel, commonly by scoring narrative information or by eliminating the inefficiencies of human scoring. This combined article presents six such efforts from operational selection systems in actual organizations. The findings show that ML can score narrative information collected from candidates either in writing or orally in response to assessment questions (called constructed response) as accurately and reliably as human judges, but much more efficiently, making such responses more feasible to include in personnel selection and often improving validity with little or no adverse impact. Moreover, algorithms can generalize across assessment questions, and algorithms can be created to predict multiple outcomes simultaneously (e.g., productivity and turnover). ML has even been demonstrated to make job analysis more efficient by determining knowledge and skill requirements based on job descriptions. Collectively, the studies in this article illustrate the likely major impact that ML will have on the practice and science of personnel selection from this point forward.
The effects of sexual and gender minority stress on relationship functioning: A meta‐analysis
Authors: Bresin Konrad , Nicholas Julia K. , Cowand Alexandra L. , Alacha Helena F. , Rodriguez Alyssa M. , Parrott Dominic J. 
Published: July 2023

AbstractTheory and research indicate that experiences of sexual and gender minority (SGM) stress among Lesbian, Gay, Bisexual, Transgender, Queer, plus (LGBTQ+) individuals are related to a variety of negative health outcomes. Because positive romantic relationships promote better physical and mental health outcomes, understanding factors that contribute positively or negatively to relationship functioning is necessary to improve relationships and promote physical and mental health. As such, the primary goals of the present study were to conduct a meta‐analysis on the association between SGM stress and (1) relationship functioning and (2) substance use, a well‐established predictor of relationship functioning. We used multivariate meta‐analysis with robust variance estimation to summarize the effects. Across 304 effects from 73 studies, we found a significant negative association between SGM stress and relationship functioning, r = −.13, 95% CI [−0.16, −0.10]. We also found significant positive associations between SGM stress and alcohol use r = .08, 95% CI [0.06, 0.11], and drug use r = .09, 95% CI [0.05, 0.13]. These small, but significant, relations are interpreted to indicate that SGM stress could erode relationship functioning and, in turn, weaken its potential protective effects against negative health outcomes, although longitudinal studies are needed.
Functional identification of ANR genes in apple (Malus halliana) that reduce saline–alkali stress tolerance
Authors: Wang W.‐X. , Zhang Z.‐X. , Wang X. , Han C. , Dong Y.‐J. , Wang Y.‐X. 
Published: July 2023

Abstract
As one of the major abiotic stresses restricting the development of global agriculture, saline–alkali stress causes osmotic stress, ion poisoning, ROS damage and high pH damage, which seriously restrict sustainable development of fruit industry. Therefore, it is essential to develop and cultivate saline–alkali‐resistant apple rootstocks to improve the yield and quality of apples in China.
Based on transcriptome data, MhANR (LOC114827797), which is significantly induced by saline–alkali stress, was cloned from Malus halliana. The physicochemical properties, evolutionary relationships and cis‐acting elements were analysed. Subsequently, the tolerance of MhANR overexpression in Arabidopsis thaliana, tobacco, and apple calli to saline–alkali stress was verified through genetic transformation.
Transgenic plants contained less Chl a, Chl b and proline, SOD, POD and CAT activity, and higher relative electrical conductivity (REC) compared to WT plants under saline–alkali stress. In addition, expression of saline–alkali stress‐related genes in overexpressed apple calli were also lower than in WT calli, including the antioxidant genes (MhSOD and MhCAT^), the Na+ transporter genes (MhCAX5, MhCAX5, MhSOS1, MhALT1), and the H+‐ATPase genes (MhAHA2 and MhAHA8), while expression of the K+ transporter genes (MhSKOR and MhNHX4) were higher.
Expression of MhANR reduced tolerance of A. thaliana, tobacco, and apple calli to saline–alkali stress by regulating osmoregulatory substances, chlorophyll content, antioxidant enzyme activity, and expression of saline–alkali stress‐related genes. This research provides a theoretical basis for cultivating apple rootstocks with effective saline–alkali stress tolerance.
Building community resilience through cross‐sector partnerships and interdisciplinary research
Authors: Ge Yue “Gurt” , Kapucu Naim , Zobel Christopher W. , Hasan Samiul , Hall Jeremy L. , Wang Haizhong , Wang Liqiang , Martín Yago , Cechowski Michelle 
Published: July 2023

AbstractBuilding community resilience has become a national imperative. Substantial uncertainties in dynamic environments of emergencies and crises require real‐time information collection and dissemination based on big data analytics. These, in turn, require networked communities and cross‐sector partnerships to build lasting resilience. This viewpoint article highlights an interdisciplinary approach to building community resilience through community‐engaged research and partnerships. This perspective leverages existing community partnerships and network resources, undertakes an all‐hazard and whole‐community approach, and evaluates the use of state‐of‐the‐art information communication technologies. In doing so, it reinforces the multifaceted intergovernmental and cross‐sector networks through which resilience can be developed and sustained.
Understanding the micro‐foundations of administrative corruption in the public sector: Findings from a systematic literature review
Authors: Weißmüller Kristina S. , Zuber Anna 
Published: July 2023

AbstractPublic sector corruption is one of the most pressing unresolved issues of our time. Based on the Theory of Planned Behavior, this study examines the psychological and contextual mechanisms that allow individuals to rationalize their engagement in administrative corruption. By conducting a systematic literature review of 93 studies, 241 cases of empirical evidence on the relationships between micro, meso, and macro‐level factors are synthesized to reveal seven dimensions, which affect civil servants' corruptibility. Mapping the status quo of the discourse, this study reveals that moral justification for administrative corruption is the outcome of a multi‐layered and dynamic process of social cognition based on various processes of rationalization beyond greed: accountability conflicts, social obligations, and culturally reinforced norms (mis‐)guide behavior in the context of socially varying psychological reference points of accountability and legitimacy that lead to essential value conflicts between self‐serving behavior and integrity.
The odd woman out: An (in)congruity analysis of gender stereotyping ingender‐dominantpublic sector professions
Authors: Dinhof Katharina , Willems Jurgen 
Published: July 2023

AbstractPublic sector professions are highly gender‐dominant (e.g., police officers, teachers) and determined not only by professionals but also by gender roles. According to the role congruity theory, these social roles result in perceived (in)congruities between the jobholders' gender and gender‐dominant professions. This research investigates this intersection for several professions. Throughout three large‐scale surveys (conducted in Austria), we first document the gender dominance of various public sector professions, and further analyze the effects from (in)congruities in gender‐dominant professions. The findings are two‐fold: First, for police officers, firefighters, politicians, nurses, and teachers, (in)congruities of job‐holder's gender with gender dominance of the profession result in positive (negative) ascriptions of job‐related traits. However, (in)congruity effects are not confirmed for other gender‐dominant professions outside the public sector. Second, no (in)congruity effects are found for perceived professionalism. Findings are important for policy makers, as well as recruiters and employers who aim to reduce gender‐related disadvantages within public sector employment.
Institutional design and biases in evaluation reports by international organizations
Authors: Eckhard Steffen , Jankauskas Vytautas , Leuschner Elena 
Published: July 2023

AbstractGovernments spend hundreds of millions on evaluations to assess the performance of public organizations. In this article, we scrutinize whether variation in the institutional design of evaluation systems leads to biases in evaluation findings. Biases may emerge because influence over evaluation processes could enable the bureaucracy to present its work in a more positive way. We study evaluation reports published by nine international organizations (IOs) of the United Nations system. We use deep learning to measure the share of positive assessments at the sentence level per evaluation report as a proxy for the positivity of evaluation results. Analyzing 1082 evaluation reports, we find that reports commissioned by operative units, as compared to central evaluation units, systematically contain more positive assessments. Theoretically, this link between institutional design choices and evaluation outcomes may explain why policymakers perceive similar tools for evidence‐based policymaking as functional in some organizations, and politicized in others.