bluuebunny/crossref_metadata_2025_split huggingface dataset:
HeadwaterstreamSNevada: Data on riparian vegetation and water parameters of headwater streams in Sierra Nevada, Spain
Authors: Salinas‐Bonillo María J. , Rodríguez‐Rodríguez Alba , López‐Carrique Enrique , Cabello Javier , Casas J. Jesús 
Published: February 2023

AbstractProviding historical data on riparian plant biodiversity and physico‐chemical parameters of stream water in Mediterranean mountains helps to assess the effects of climate change and other human stressors on these sensitive and critical ecosystems. This database collects data from the main natural headwater streams of the Sierra Nevada (southeastern Spain), a high mountain (up to 3479 m above sea level [m asl]) recognized as a biodiversity super hotspot in the Mediterranean basin. On this mountain, rivers and landscapes depend on snowmelt water, representing an excellent scenario for evaluating global change's impacts. This dataset covers first‐ to third‐order headwater streams at 41 sites from 832 to 1997 m asl, collected from December 2006 to July 2007. Our goal is to supply information on the vegetation associated with streambanks, the essential physico‐chemical parameters of stream water, and the physiographic features of the subwatersheds. Riparian vegetation data correspond to six plots sampled at each site, including total canopy, individual number, height and DBH (diameter at breast height) in woody species, and cover percentage for herbs. Physico‐chemical parameters were measured in situ (electric conductivity, pH, dissolved O2 concentration, stream discharge) and determined in the laboratory (alkalinity, soluble reactive phosphate‐phosphorus [SRP], total phosphorus [TP], nitrate‐nitrogen [–N], ammonium‐nitrogen [–N], total nitrogen [TN]). Watershed physiographic variables comprise drainage area, minimum altitude, maximum altitude, mean slope, orientation, stream order, stream length, and land cover surface percentage. We recorded 197 plant taxa (67 species, 28 subspecies, and 2 hybrids), representing 8.4% of the Sierra Nevada vascular flora. Due to the botanical nomenclature used, the database can be linked to FloraSNevada database, contributing to Sierra Nevada (Spain) as a laboratory of global processes. This data set can be freely used for non‐commercial purposes. Users of these data should cite this data paper in any publications resulting from its use.
Epidemiological characteristics and real‐world treatment outcomes of hepatitis C among HIV/HCV co‐infected patients in Myanmar: A prospective cohort study
Authors: Swe Thein Min , Johnson Derek. C. , Mar Htay Thet , Thit Phone , Homan Tobias , Chu Cherry May , Mon Phyu Ei , Thwe Thin Thin , Soe Kyi Pyar , Ei Win Le Shwe Sin , Tun Nyan Lynn , Lwin Kyaw Zay , Karakozian Hayk , Aung Khin Sanda , Nguyen Aude , Ciglenecki Iza , Tamayo Natalia , Loarec Anne 
Published: February 2023

AbstractBackground and AimsIn Myanmar, public sector treatment programs for hepatitis C virus (HCV) infection were nonexistent until June 2017. WHO highlights the importance of simplification of HCV service delivery through task‐shifting among health workers and decentralization to the primary health care level. Between November 2016 and November 2017, a study was conducted to describe the epidemiological data and real‐world outcomes of treating HIV/HCV coinfected patients with generic direct acting antiviral (DAA) based regimens in the three HIV clinics run by nonspecialist medical doctors in Myanmar.MethodsHCV co‐infection among people living with HIV (PLHIV) from two clinics in Yangon city and one clinic in Dawei city was screened by rapid diagnostic tests and confirmed by testing for viral RNA. Nonspecialist medical doctors prescribed sofosbuvir and daclatasvir based regimens (with or without ribavirin) for 12 or 24 weeks based on the HCV genotype and liver fibrosis status. Sustained virologic response at 12 weeks after treatment (SVR12) was assessed to determine cure.ResultsAbout 6.5% (1417/21,777) of PLHIV were co‐infected with HCV. Of 864 patients enrolled in the study, 50.8% reported history of substance use, 27% history of invasive medical procedures and 25.6% history of incarceration. Data on treatment outcomes were collected from 267 patients of which 257 (96.3%) achieved SVR12, 7 (2.6%) failed treatment, 2 (0.7%) died and 1 (0.4%) became loss to follow‐up.ConclusionThe study results support the integration of hepatitis C diagnosis and treatment with DAA‐based regimens into existing HIV clinics run by nonspecialist medical doctors in a resource‐limited setting. Epidemiological data on HIV/HCV co‐infection call for comprehensive HCV care services among key populations like drug users and prisoners in Yangon and Dawei.
The impact of adjunctive aripiprazole on QT interval: A 12‐week open label study in patients on olanzapine, clozapine or risperidone
Authors: Pilunthanakul Thanita , Ting Mable Quek Jing , Lee Jimmy , Gupta Bhanu 
Published: February 2023

AbstractObjectiveTo evaluate the effect of adjunct aripiprazole on QT of patients clinically stabilized on atypical antipsychotics.MethodsThe dataset was from an open‐label 12‐week prospective trial that evaluated adjunctive use of 5 mg/day of aripiprazole on metabolic profile in patients with schizophrenia, or schizoaffective disorder stabilized on olanzapine, clozapine, or risperidone. Bazett‐corrected QT (QTc) was manually calculated from ECGs measured at baseline (before aripiprazole) and week 12, by two doctors blind to the diagnosis and atypical antipsychotic. The change in QTc (∆QTc: baseline QTc–week 12 QTc) and the number of participants in normal, borderline, prolonged, and pathological groups after 12 weeks were analyzed.ResultsFifty‐five participants, mean age of 39.3 (SD 8.2) years, were analyzed. The ∆QTc after 12 weeks was 5.9 ms (p = 0.143) for the whole sample; 16.4 ms (p = 0.762), 3.7 ms (p = 0.480) and 0.5 ms (p = 0.449), for the clozapine, risperidone and olanzapine group, respectively. There was no significant statistical difference comparing the change in QTc overall, and between atypical antipsychotic groups, when evaluating from baseline to endpoint. However, stratifying the sample based on sex‐dependent QTc cut‐offs showed a 45% decrease in abnormal QTc readings (p = 0.049) after aripiprazole initiation; 20 subjects had abnormal QTc at baseline, while only 11 subjects had abnormal QTc at 12 weeks. 25.5% of participants showed a reduction in at least one QTc severity group, while 65.5% had no change and 9.0% worsened in QTc group, after 12 weeks of adjunct aripiprazole.ConclusionLow‐dose adjunctive aripiprazole did not prolong QTc in patients stabilized on either olanzapine, risperidone, or clozapine. More controlled studies evaluating the QTc effect of adjunctive aripiprazole should be done to confirm and support these findings.
Savoring interventions for mothers of young children: Mechanisms linking relational savoring and personal savoring to reflective functioning
Authors: Borelli Jessica L. , Kazmierski Kelly F. M. , Gaskin Gerin E. , Kerr Margaret L. , Smiley Patricia A. , Rasmussen Hannah F. 
Published: February 2023

AbstractParenting interventions can improve parenting outcomes, with widespread implications for children's developmental trajectories. Relational savoring (RS) is a brief attachment‐based intervention with high potential for dissemination. Here we examine data from a recent intervention trial in order to isolate the mechanisms by which savoring predicts reflective functioning (RF) at treatment follow‐up through an examination of the content of savoring sessions (specificity, positivity, connectedness, safe haven/secure base, self‐focus, child‐focus). Mothers (N = 147, Mage = 30.84 years, SDage = 5.13; Race: 67.3% White/Caucasian, 12.9% other or declined to state; 10.9% biracial/multiracial, 5.4% Asian, 1.4% Native American/Alaska Native, 2.0% Black/African American; Ethnicity: 41.5% Latina) of toddlers (Mage = 20.96 months, SDage = 2.50; 53.5% female) were randomized to four sessions of RS or personal savoring (PS). Both RS and PS predicted higher RF, but through different means. RS was indirectly associated with higher RF through greater connectedness and specificity of savoring content, while PS was indirectly associated with higher RF through greater self‐focus in savoring content. We discuss the implications of these findings for treatment development and for our understanding of the emotional experience of mothers of toddlers.
Integrating genomics and conservation to safeguard plant diversity
Authors: Schneider Harald 
Published: February 2023

AbstractConserving genetic diversity has been increasingly recognized as a keystone towards the protection of biodiversity and natural resources for future generations of humankind. In turn, the ongoing genomic revolution provides us with the technical innovations and expanded knowledge required to establish programs to integrate genomic approaches into programs to protect plant diversity and its genetic diversity. Although obtaining whole genomes of all organisms is still a far‐fetched dream, rapid progress in assembling whole genomes across the plant tree‐of‐life has provided access to reference genomes for many plants but, unfortunately, not all lineages of the plant tree‐of‐life. Addressing the existing taxon gaps is arguably best achieved by focusing on the genomes of plant species that experience high extinction threats or play a crucial role in ecosystem restoration. This review summarizes not only the recent progress in plant genomics with an emphasis on their importance to the conservation of plant diversity but also outlines steps to integrate genomics into plant conservation. Given the complexity of threats driving plant extinction, such as reduced genetic diversity, enhanced genome erosion, and loss of species integrity by hybridization, the integration of genomic research into our conservation efforts is crucial to understand extinction processes and, most importantly, to support the targets set to achieve “Harmony with Nature.”
Molecular characterizations of antibiotic resistance, biofilm formation, and virulence determinants of Pseudomonas aeruginosa isolated from burn wound infection
Authors: Ghasemian Shirin , Karami‐Zarandi Morteza , Heidari Hamid , Khoshnood Saeed , Kouhsari Ebrahim , Ghafourian Sobhan , Maleki Abbas , Kazemian Hossein 
Published: February 2023

AbstractBackgroundBurn injuries result in disruption of the skin barrier against opportunistic infections. Pseudomonas aeruginosa is one of the main infectious agents colonizing burn wounds and making severe infections. Biofilm production and other virulence factors along with antibiotic resistance limit appropriate treatment options and time.Materials and MethodsWound samples were collected from hospitalized burn patients. P. aeruginosa isolates and related virulence factors identified by the standard biochemical and molecular methods. Antibiotic resistance patterns were determined by the disc diffusion method and β‐lactamase genes were detected by polymerase chain reaction (PCR) assay. To determine the genetic relatedness amongst the isolates, enterobacterial repetitive intergenic consensus (ERIC)‐PCR was also performed.ResultsForty P. aeruginosa isolates were identified. All of these isolates were biofilm producers. Carbapenem resistance was detected in 40% of the isolates, and blaTEM (37/5%), blaVIM (30%), and blaCTX‐M (20%) were the most common β‐lactamase genes. The highest resistance was detected to cefotaxime, ceftazidime, meropenem, imipenem and piperacillin, and 16 (40%) isolates were resistant to these antibiotics. The minimum inhibitory concentrations (MIC) of colistin was lower than 2 μg/mL and no resistance was observed. Isolates were categorized to 17 MDR, 13 mono‐drug resistance, and 10 susceptible isolates. High genetic diversity was also observed among the isolates (28 ERIC types) and most carbapenem‐resistant isolates were classified into four main types.ConclusionAntibiotic resistance, particularly carbapenem resistance was considerable among the P. aeruginosa isolates colonizing burn wounds. Combining carbapenem resistance with biofilm production and virulence factors would result in severe and difficult‐to‐treat infections.
Morphological comparison of the sensilla on the maxillary and labial palps between male and female adults of Moechotypa diphysis (Coleoptera: Cerambycidae)
Authors: Liu Chang‐Tai , Tong Xin 
Published: February 2023

AbstractMoechotypa diphysis (Pascoe) is one of the most important pests in agriculture and forestry. However, there are few studies focusing on the external morphology of M. diphysis adults. In this study, the mouthparts of M. diphysis adults were observed by the scanning electron microscope to compare the quantity and distribution of the sensilla on the maxillary and labial palps. The results showed that there are four segments on the maxillary palps and three segments on the labial palps. The length of each segment of the maxillary and labial palps is larger in the female than that in the male. Six types of sensilla are found on the maxillary and labial palps of M. diphysis adults: sensilla basiconca (SB1, 2, 3, and 4), sensilla trichodea (ST1, 2 and 3), sensilla chaetica (SC), sensilla placodea (SP), hair plate (HP) and sensilla coeloconica (SCo). There is no significant difference in the number of most types of sensilla between females and males in the same position. However, the number of ST1 on the maxillary and labial palps is significantly higher in the female than in the male. In addition, the number of most types of sensilla (SB2, ST1, SC, SP, HP, and SCo) on the maxillary palps is significantly higher than on the labial palps both for females and males. Maxillary palps may play a more important role in the activities of M. diphysis adults than the labial palps. Based on this study, we discussed the functions of the sensilla on the maxillary and labial palps of M. diphysis adults to provide the theoretical basis and statistical data for further research on the behavior and the electrophysiology of this devastating forest pest.
Heat hardening of a larval amphibian is dependent on acclimation period and temperature
Authors: Dallas Jason , Warne Robin W. 
Published: February 2023

AbstractPlasticity in heat tolerance provides ectotherms the ability to reduce overheating risk during thermal extremes. However, the tolerance–plasticity trade‐off hypothesis states that individuals acclimated to warmer environments have a reduced plastic response, including hardening, limiting their ability to further adjust their thermal tolerance. Heat hardening describes the short‐term increase in heat tolerance following a heat shock that remains understudied in larval amphibians. We sought to examine the potential trade‐off between basal heat tolerance and hardening plasticity of a larval amphibian, Lithobates sylvaticus, in response to differing acclimation temperatures and periods. Lab‐reared larvae were exposed to one of two acclimation temperatures (15°C and 25°C) for either 3 or 7 days, at which time heat tolerance was measured as critical thermal maximum (CTmax). A hardening treatment (sub‐critical temperature exposure) was applied 2 h before the CTmax assay for comparison to control groups. We found that heat‐hardening effects were most pronounced in 15°C acclimated larvae, particularly after 7 days of acclimation. By contrast, larvae acclimated to 25°C exhibited only minor hardening responses, while basal heat tolerance was significantly increased as shown by elevated CTmax temperatures. These results are in line with the tolerance–plasticity trade‐off hypothesis. Specifically, while exposure to elevated temperatures induces acclimation in basal heat tolerance, shifts towards upper thermal tolerance limits constrain the capacity for ectotherms to further respond to acute thermal stress.
Tax and governance in rural areas: The implications of inefficient tax collection
Authors: van den Boogaard Vanessa , Beach Rachel 
Published: February 2023

AbstractWhile there has been increasing policy attention on broadening tax bases in low‐income countries, taxing citizens in rural areas often leads to neither revenue gains nor stronger accountability outcomes. Through case studies of Sierra Leone and Togo, we demonstrate that revenue collection in rural areas is highly inefficient, leading to little, if any, revenue gains after factoring in collection costs. Accordingly, we question the existing rationales for extending taxation to rural citizens in low‐income countries. Instead, we argue for a rethinking of the role of taxation in rural areas, considering the nature of social contracts and limited fiscal reciprocity.
Nonopioid pharmacological management of acute low back pain: A level I of evidence systematic review
Authors: Baroncini Alice , Maffulli Nicola , Al‐Zyoud Hazim , Bell Andreas , Sevic Aleksandar , Migliorini Filippo 
Published: February 2023

AbstractAcute low back pain (LBP) imposes a significant socioeconomical burden as it is the condition that, worldwide, cause the most disability. Nonetheless, the literature regarding the best pharmacological management of acute LBP is limited, and the indications available in the literature are conflicting. This work investigates whether the pharmacological management of acute LBP can effectively reduce pain and disability, and aims to identify which drugs show the highest efficacy. This systematic review was conducted according to the 2020 PRISMA statement. In September 2022, PubMed, Scopus, and Web of Science were accessed. All the randomized controlled trials investigating the efficacy of myorelaxants, nonsteroidal anti‐inflammatory drugs (NSAIDs), and paracetamol for acute LPB were accessed. Only studies that investigated the lumbar spine were included. Only studies reporting on patients with acute LBP with symptom duration of less than 12 weeks were included. Only patients older than 18 years and with nonspecific low back pain were included. Studies that investigated the use of opioids in acute LBP were not considered. Data from 18 studies and 3478 patients were available. Myorelaxants and NSAIDs were effective in reducing pain and disability in acute LBP at approximately one week. The combination of NSAIDs and paracetamol was associated with a greater improvement than the use of NSAIDs alone, but paracetamol alone did not induce any significant improvement. Placebo was not effective in reducing pain. Clinical Significance: Myorelaxants, NSAIDs, and NSAIDs with paracetamol could reduce pain and disability in patients with acute LBP.
Impact of linked color imaging and blue laser imaging on the diagnosis of esophageal squamous cell carcinoma in iodine unstained areas
Authors: Tsunoda Masato , Miura Yoshimasa , Osawa Hiroyuki , Nagayama Manabu , Kagaya Yuka , Funayama Yohei , Kobayashi Takuma , Togashi Mami , Hayashi Hiroki , Hiraoka Yuji , Nomoto Yoshie , Iwashita Chihiro , Ino Yuji , Takahashi Haruo , Fukuda Hisashi , Lefor Alan Kawarai , Yamamoto Hironori 
Published: February 2023

AbstractThe pink color sign in iodine unstained areas is useful to differentiate esophageal squamous cell carcinoma (ESCC) from other lesions. However, some ESCCs have obscure color findings which affect the ability of endoscopists to differentiate these lesions and determine the resection line. Using white light imaging (WLI), linked color imaging (LCI) and blue laser imaging (BLI), 40 early ESCCs were retrospectively evaluated using images before and after iodine staining. Visibility scores for ESCC by expert and non‐expert endoscopists were compared using these three modalities and color differences measured for malignant lesions and surrounding mucosa. BLI had the highest score and color difference without iodine staining. Each determination with iodine was much higher than without iodine regardless of the modality. With iodine, ESCC mainly appeared pink, purple and green using WLI, LCI and BLI, respectively and visibility scores determined by non‐experts and experts were significantly higher for LCI (both p < 0.001) and BLI (p = 0.018 and p < 0.001) than for WLI. The score with LCI was significantly higher than with BLI among non‐experts (p = 0.035). With iodine, the color difference using LCI was twice that with WLI and one with BLI was significantly larger than with WLI (p < 0.001). These greater tendencies were found regardless of location, depth of cancer or intensity of pink color using WLI. In conclusion, areas of ESCC unstained by iodine were easily recognized using LCI and BLI. Visibility of these lesions is excellent even by non‐expert endoscopists, suggesting that this method is useful to diagnose ESCC and determine the resection line.
pH‐Responsive and Recyclable Hydrogels for Gas Releasing and Scavenging
Authors: Zhou Xiaozhuang , Kandalai Shruthi , Hossain Farzana , Zhang Nan , Li Huapeng , Zheng Qingfei 
Published: February 2023

AbstractGas‐releasing/scavenging hydrogels have wide applications in biomedical and industrial fields. However, the covalently crosslinked nature of these existing materials makes them difficult to degrade or recycle, leading to a waste of raw materials and aggravating environmental pollution. Herein, a new class of pH‐responsive and recyclable hydrogels with versatile gas‐releasing and scavenging properties is reported, utilizing pH changes to reversibly control disassembly and reassembly of the hydrogel network. The initial hydrogels are constructed via the one‐pot radical polymerization and contain dynamic molecular networks based on hydrophobic interactions, which can disassemble when the materials are placed in low pH solutions. The disassembled copolymer chains can reform hydrogels, following supplementation with fresh mineral salts and micelle monomers in neutral solutions. Moreover, the mineral salts used to reform hydrogels can function as gas donors or scavengers, endowing these hydrogels with versatile gas‐releasing and consuming properties. Overall, this research provides a facile and environmentally friendly method to recycle hydrogels with gas‐releasing and gas‐scavenging properties, which have potential applications in diverse fields, including wound healing, wastewater management, and gas therapy for diseases.
Administration Time and Dietary Patterns Modified the Effect of Inulin on CUMS‐Induced Anxiety and Depression
Authors: Chen Ping , Li Xiaofang , Yu Ying , Zhang Jiaming , Zhang Yingying , Li Chunmei , Li Jing , Li Kaikai 
Published: February 2023

ScopePrebiotics exert anxiolytic and antidepressant effects through the microbiota‐gut‐brain axis in animal models. However, the influence of prebiotic administration time and dietary pattern on stress‐induced anxiety and depression is unclear. In this study, whether administration time can modify the effect of inulin on mental disorders within normal and high‐fat diets are investigated.Methods and resultsMice subjected to chronic unpredicted mild stress (CUMS) are administered with inulin in the morning (7:30–8:00 am) or evening (7:30–8:00 pm) for 12 weeks. Behavior, intestinal microbiome, cecal short‐chain fatty acids, neuroinflammatory responses, and neurotransmitters are measured. A high‐fat diet aggravated neuroinflammation and is more likely to induce anxiety and depression‐like behavior (p < 0.05). Morning inulin treatment improves the exploratory behavior and sucrose preference better (p < 0.05). Both inulin treatments decrease the neuroinflammatory response (p < 0.05), with a more evident trend for the evening administration. Furthermore, morning administration tends to affect the brain‐derived neurotrophic factor and neurotransmitters.ConclusionAdministration time and dietary patterns seem to modify the effect of inulin on anxiety and depression. These results provide a basis for assessing the interaction of administration time and dietary patterns, providing guidance for the precise regulation of dietary prebiotics in neuropsychiatric disorders.