bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRADE MARKETING AS A TOOL FOR ADVERTIZING MANAGEMENT AND CUSTOMER LOYALTY MANAGEMENT
Authors: Boiko Ruslan , Andrushkevych Zinayida 
Published: February 2023

The article highlights the main problems of using trade marketing as one of the most effective advertizing management tools for managing consumer loyalty. It is indicated on the relevance of the topic under conditions of market relations for enterprises. The works of scientists involved in the study of these issues have been analyzed, and insufficiently investigated aspects are singled out. It is noted that current trends to increase competition in the market of retail trade establishments in Ukraine require enterprises to intensify efforts in order to motivate consumers to make a purchase and maintain their loyalty.
Emphasis is placed on the fact that the use of trade marketing tools is aimed at increasing the consumer value of goods for end consumers. The target audience to which trade marketing tools are directed is indicated. The main tools of trade marketing for the target audience to which they are directed and its modern trade marketing tools are considered. A special place of merchandising in the management of the activities of a retail enterprise based on trade marketing is indicated. Formulated indicators, which determine the effectiveness of the implementation of trade marketing tools in the activities of retail enterprises.
The main tools of trade marketing are illustrated depending on the place of implementation and method of application. It is noted that every year some marketing tools lose their effectiveness, others become more important.It was emphasized that due to quarantine restrictions triggered by COVID-19, remote, contactless sales became especially relevant, which contributed to the emergence of new trade marketing tools.
To identify problems in the work of the company was conducted marketing research through a survey of consumers of its products. At the beginning of the study, we put forward several hypotheses about the situation at the enterprise. As a result of the study, some hypotheses were confirmed and some were refuted.
It was concluded that the development and implementation of trade marketing tools in the activities of a retail trade institution will contribute to retaining existing customers and attracting new ones, stimulating buyers to make repeat purchases, forming emotional attachment and customer loyalty to the institution, improving the advertising and communication policy of the institution, increasing sales.
The Regime of Invisibility in Closed Spaces of Debate
Authors: Chailleux Sébastien , Zittoun Philippe 
Published: February 2023

Abstract
Our empirical study tackles the definition of shale gas within the French administration and gas companies before social mobilization erupted in 2011. We analyze how and why shale gas was neither considered problematic nor perceived as part of the political agenda, even though it was the object of policymaking. We argue that shale gas was caught up in a regime of invisibility shaped by the actors in charge of dealing with license requests. Invisibility was made possible by the administration's cadastral department, which considered itself as the sole expert in granting licenses, and because of the department's marginal position within the administration, which rendered shale gas proponents invisible to their own hierarchy. This regime of invisibility helped define shale gas as a “non-problem.”
Does “Social” Mean “Public”?
Authors: Hubert Wit , Wagner Aleksandra 
Published: February 2023

Abstract
The article presents an analysis of the use of Facebook on the over 400-day-long anti-fracking protest by farmers in the village of Żurawlów in Poland against the global corporation Chevron. Analysis of this case study was used to discuss the deliberative potential of social media and their power in countering hegemonic discourse and providing visibility in the public sphere to actors and arguments marginalized or excluded by the traditional media. The results discuss Facebook's potential for mobilizing and providing identity while emphasizing the problem of visibility in the public sphere, which was key to the inclusion of discourse in public debate. Harnessing emotions and legitimizing minority interests helped create counter-power, while polarization and “homophile acts” against deliberation geared toward arriving at an agreement.
UPAYA PENINGKATAN KINERJA PUSTAKAWAN DI DINAS PERPUSTAKAAN DAN KEARSIPAN KABUPATEN LOMBOK TIMUR
Authors: Ridwan Ridwan , Lubis Lubis , Furbani Widiastuti , Saleh Amin 
Published: February 2023

Dinas Perpustakaan dan Kearsipan Kabupaten Lombok Timur memiliki SDM pustakawan hanya empat orang, dimana menurut Standar Nasional Perpustakaan satu orang pustakawan melayani 75 ribu orang dalam Perpustakaan Umum Daerah, sedangkan jumlah masyarakat yang ada di Kabupaten Lombok Timur 1.105.582 jiwa. Berarti pustakawan yang ada di Dinas Perpustakaan dan Kearsipan Kabupaten Lombok Timur masih sangat terbatas. Pustakawan di Dinas Perpustakaan dan Kearsipan Kabupaten Lombok Timur dapat meningkatkan kualitas layanan dilihat dari aspek akses informasi yang uptodate dan lengkap, pustakawan menerapkan prinsip 5S (affect of service), menerapkan personal control, sehingga dengan memenuhi aspek tersebut kepuasan pemustaka dapat terwujud. Upaya pustakawan dalam meningkatkan kinerjanya seperti menempuh pendidikan dan pelatihan, banyak membaca referensi, memperoleh fasilitas sarana dan prasarana, melakukan kerjasama, mendapatkan dukungan atau motivasi, melaksanakan program kerja dan SKP. Sedangkan dari sisi kendala pustakawan mendapatkan berbagai kendala seperti belum mendapat pembinaan secara maksimal, belum mendapat tunjangan kesejahteraan secara maksimal, mengalami waktu yang tergesa-gesa pada saat kegiatan progran kerja berlangsung.
Production and evaluation of extruded products from decorticated maize (Zea mays L.) flour supplemented with decorticated selected legume flour
Authors: Awad Shereen Mohammed , Mustafa Abdelmoneim Ibrahim , Kabbashi Esameldin B. M. 
Published: February 2023

Maize (Zea mays L) is an important staple food in Africa where in Sudan it's a prospective crop. The nutritional value of this crop needs some fortification to compensate for some nutritional deficiencies. The results obtained from decorticated maize flour supplemented with different ratios of decorticated faba bean (Vicia faba L.) (dfb) and decorticated cow pea (Vigna unguiculata) (dcp) on extrusion products indicated an increase in protein content of 2.1 % ( from 13.86 to 15.96%) in dfb and (from 12.77 to 14.87%) in dcp. The results indicate that tannins and phytic acid content in extruded products were lower than in blend. Tannins content for extruded products range is 222 – 230.24 mg/100g in dfb products, and 227.68 – 233 mg/100g in dcp products compared to a range of 393.34 – 415.32 in dfb blends, and 355.74 – 379.71 mg/100g in dcp blends. Phytic acid content for extruded products range was 174.30 – 196.01 in dfb products, and 167.20 – 188.01 mg/100g in dcp products compared to 202.47 – 229.35 mg/100g in dfb blends and 198.47 – 212.88 mg/100g in dcp blends. This means that the extrusion cooking reduced antinutritional factors. Heedless, a significant (P≤0.05) increase in minerals content (Ca, K, P, Na, Fe and Mg) was noticed because of adding dfb and dcp to the products compared to control. Essential amino acids in test products were increased compared to the control ones. The protein quality in dfb and dcp products was improved and the lysine score increased from 15.40 to 38.42 and from 16.20 to 49.33 for in these products, respectively. Extruded samples supplemented with 5% dfb and dcp, separately, had significant (P≤0.05) increase in volume by 10 and 20 cm3, respectively. Sensory evaluation of extruded products showed that supplementation with 5% dfb and dcp resulted in superior products in color, taste, crispness and general acceptability. However, extruded products of dfb reflected superior quality than those of dcp. Nevertheless, the study showed that the extruded products of dfb and dcp are better than the control. Eventually, these results recommend producing extruded products from decorticated maize flour supplemented with 5% dfb or dcp in order
Mopho-molecuar identification of Fusarium oxysporum as the causal agent of dry rot of carrot in Pakistan
Authors: Ghuffar Salman , Saeed Muhammad Sajjad , Abbas Waseem , Iqbal Muhammad , Mehmood Nasir , Sabtain Umar , Yasin Muhammad Ussama , Qayyum Abdul , Rauf Muhammad 
Published: February 2023

Fusarium rot or dry rot is an emerging threat to carrot field, which is responsible for significant economic losses worldwide. The objective of this study was to identify Fusarium species associated with dry rot of carrot (Daucus carota).For this porpuse, ten isolates of Fusarium sp. were collected from symptomatic carrot roots at Vegetable Research Station Sahiwal (VRSS). During morphological studies, fungal colonies were observed whitish, cottony with abundunt arial mycelium. In microscopic observations, macroconidia was falciform and measured 12.1 to 30.7 (L) × 3.6 to 5.8 (W) μm with 2 to 3 septations, while elliptic microconidia of 5.8 to 8.6 (L) × 2.9 to 3.6 (W) μm with none or one septate. For molecular characterization, three isolates (ON955520, ON955053 & ON955054) were amplified using ITS1 & ITS4 primers. Sequence comparison revealed 99-100% genetic homology with previously reported isolates of F.oxysporum. To our knowledge, the occurrence of fusarium rot caused by F.oxysporum on carrot field is the first time reported in Pakistan which can cause reduction in crop yield.
Acquired disorders of mitochondrial metabolism and dynamics in pulmonary arterial hypertension
Authors: Breault Nolan M. , Wu Danchen , Dasgupta Asish , Chen Kuang-Hueih , Archer Stephen L. 
Published: February 2023

Pulmonary arterial hypertension (PAH) is an orphan disease of the cardiopulmonary unit that reflects an obstructive pulmonary vasculopathy and presents with hypertrophy, inflammation, fibrosis, and ultimately failure of the right ventricle (RVF). Despite treatment using pulmonary hypertension (PH)-targeted therapies, persistent functional impairment reduces the quality of life for people with PAH and death from RVF occurs in approximately 40% of patients within 5 years of diagnosis. PH-targeted therapeutics are primarily vasodilators and none, alone or in combination, are curative. This highlights a need to therapeutically explore molecular targets in other pathways that are involved in the pathogenesis of PAH. Several candidate pathways in PAH involve acquired mitochondrial dysfunction. These mitochondrial disorders include: 1) a shift in metabolism related to increased expression of pyruvate dehydrogenase kinase and pyruvate kinase, which together increase uncoupled glycolysis (Warburg metabolism); 2) disruption of oxygen-sensing related to increased expression of hypoxia-inducible factor 1α, resulting in a state of pseudohypoxia; 3) altered mitochondrial calcium homeostasis related to impaired function of the mitochondrial calcium uniporter complex, which elevates cytosolic calcium and reduces intramitochondrial calcium; and 4) abnormal mitochondrial dynamics related to increased expression of dynamin-related protein 1 and its binding partners, such as mitochondrial dynamics proteins of 49 kDa and 51 kDa, and depressed expression of mitofusin 2, resulting in increased mitotic fission. These acquired mitochondrial abnormalities increase proliferation and impair apoptosis in most pulmonary vascular cells (including endothelial cells, smooth muscle cells and fibroblasts). In the RV, Warburg metabolism and induction of glutaminolysis impairs bioenergetics and promotes hypokinesis, hypertrophy, and fibrosis. This review will explore our current knowledge of the causes and consequences of disordered mitochondrial function in PAH.
Cation functional group effect on SO2 absorption in amino acid ionic liquids
Authors: Siami Hasan , Razmkhah Mohammad , Moosavi Fatemeh 
Published: February 2023

Introduction: The effect of the functional group of the cation on SO2 acidic gas absorption by some designed amino acid ionic liquids (AAILs) was studied.Methods: An isolated pair of glycinate anion and pristine imidazolium-based cation, as well as decorated cation functionalized by hydroxyl (OH), amine (NH2), carboxylic acid (COOH), methoxy (OCH3), and acetate (CH3COO) groups, were structurally optimized by density functional theory (DFT) using split-valence triple-zeta Pople basis set.Results and Discussion: The binding and Gibbs free energy (ΔGint) values of SO2 absorption show the AAIL functionalized by the COOH group is the most thermodynamically favorable green solvent and this functional group experiences the closest distance between anion and captured SO2 and vice versa in the case of cation … SO2 which may be the main reason for being the best absorbent; in addition, the highest net charge-transfer amount of SO2 is observed. Comparing the non-covalent interaction of the systems demonstrates that the strongest hydrogen bond between captured gas and anion, as well as π-hole, and van der Waals (vdW) interaction play critical roles in gas absorption; besides, the COOH functional group decreases the steric effect while the CH3COO functional group significantly increases steric effect after absorption that declines the hydrogen bond.
How climate scientists and communication professionals view public engagement with science: Perspectives, practices and constraints
Authors: Oliveira Liliana , Carvalho Anabela 
Published: February 2023

IntroductionThis article examines understandings of public engagement in science by scientists and communicators in four universities in Portugal and Spain.MethodsBased on mixed-methods research, we present an integrative analysis of practices and perceptions of climate change scientists and communication professionals, and identify critical barriers for them to further public engagement.ResultsMore similarities than differences are found between the four universities and the two countries but there are important differences between the two professional groups. Universities and the scientific community at large tend to privilege forms of science communication that are focused on dissemination of information and on self-promotion. Over the last decade there are signs of positive developments, even though some aspects of science communication practice appear to have worsened.DiscussionDespite the advancements presented this article Portuguese and Spanish universities are not yet making the most of the potential inherent to public engagement. This raises important questions for research and practice. Although several interviewees acknowledge a normative requirement of having citizens participate more deeply in science, they stay short of fulfilling such commitment. This may be partly due to implementation barriers but also because scientists and especially communication professionals make a relatively narrow reading of the potential benefits of engaging the public in science.
Analysis of CYP2C19 gene polymorphism and influencing factors of pharmacological response of clopidogrel in patients with cerebral infarction in Zhejiang, China
Authors: Mo Yijun , Lu Yao , Guo Fei , Wu Aihua , Weng Yuesong 
Published: February 2023

BackgroundCertain genetic and non-genetic factors may cause damaged platelet inhibition by clopidogrel. We aimed to determine the effect of cytochrome P4502C19 (CYP2C19) polymorphism, along with other clinical factors, on the platelet response to clopidogrel in patients with acute ischemic stroke (AIS).MethodsA total of 214 patients with AIS receiving clopidogrel at a maintenance dose of 75 mg daily admitted to the Ningbo First Hospital between 1 January 2020, and 31 December 2021, were enrolled. Platelet aggregation analysis was performed to determine clopidogrel resistance. Quantitative real-time polymerase chain reaction (QRT-PCR) was used to determine CYP2C19 genotype. Other laboratory data on complete blood count and biochemical parameters were taken from patient medical files.ResultsAmong the 214 AIS patients treated with clopidogrel in the Ningbo population, the incidence of clopidogrel resistance was approximately 43.9%, and the distribution of CYP2C19 genotypes was highest for CYP2C19(*1/*2) (43.0%), followed by CYP2C19 (*1/*1) (38.8%). The distribution of alleles *1, *2, *3, and *17 was 62.1, 32.5, 4.9, and 0.5%, respectively. A chi-squared test showed that the gene frequencies of alleles *2 and *3 were significantly higher in the clopidogrel-resistant group than in the clopidogrel-sensitive group (p &lt; 0.001), and a Mann–Whitney U-test showed that high HCY levels were significantly correlated with clopidogrel resistance (p &lt; 0.001). Multi-factor logistic regression analysis demonstrated that mutant heterozygous genotype [OR 2.893; 95% confidence interval (CI) 1.456–5.748; p = 0.002], mutant homozygous genotype (OR 4.741; 95% CI 1.828–12.298; p = 0.001), and high HCY levels (OR 1.209; 95% CI 1.072–1.362; p = 0.002) were significantly associated with clopidogrel resistance.ConclusionAccording to our results, carrying the CYP2C19*2/*3 allele and high HCY levels are independent risk factors for clopidogrel resistance after clopidogrel therapy in patients with AIS. These two factors should be considered prior to clopidogrel administration.
Impact of coronary computed tomography angiography-derived fractional flow reserve based on deep learning on clinical management
Authors: Pan Yueying , Zhu Tingting , Wang Yujijn , Deng Yan , Guan Hanxiong 
Published: February 2023

BackgroundTo examine the value of coronary computed tomography angiography (CCTA)-derived fractional flow reserve based on deep learning (DL-FFRCT) on clinical practice and analyze the limitations of the application of DL-FFRCT.MethodsThis is an observational, retrospective, single-center study. Patients with suspected coronary artery disease (CAD) were enrolled. The patients underwent invasive coronary angiography (ICA) examination within 1 months after CCTA examination. And quantitative coronary angiography (QCA) was performed to evaluate the area stenosis rate. The CCTA data of these patients were retrospectively analyzed to calculate the FFRCT value.ResultsA total of 485 lesions of coronary arteries in 229 patients were included in the analysis. Of the lesions, 275 (56.7%) were ICA-positive, and 210 (43.3%) were FFRCT-positive. The discordance rate of the risk stratification of FFRCT for ICA-positive lesions was 33.1% (91) and that for ICA-negative lesions was 12.4% (26). 14.6% (7/48) patients with mild to moderate coronary stenosis in ICA have functional ischemia according to FFRCT positive indications. In addition, hemodynamic analysis of severely calcified, occluded, or small (&lt; 2 mm in diameter) coronary arteries by DL-FFRCT is not so reliable.ConclusionThis study revealed that most patients with ICA negative did not require further invasive FFR. Besides, some patients with mild to moderate coronary stenosis in ICA may also have functional ischemia. However, for severely calcified, occluded, or small coronary arteries, treatment strategy should be selected based on ICA in combination with clinical practice.
Campylobacter in aquatic and terrestrial mammals is driven by life traits: A systematic review and meta-analysis
Authors: Brooks Michael R. , Medley Sarah , Ponder Monica , Alexander Kathleen A. 
Published: February 2023

IntroductionCampylobacter spp. infections are responsible for significant diarrheal disease burden across the globe, with prevalence thought to be increasing. Although wild avian species have been studied as reservoirs of Campylobacter spp., our understanding of the role of wild mammalian species in disease transmission and persistence is limited. Host factors influencing infection dynamics in wild mammals have been neglected, particularly life traits, and the role of these factors in zoonotic spillover risk is largely unknown.MethodsHere, we conducted a systematic literature review, identifying mammalian species that had been tested for Campylobacter spp. infections (molecular and culture based). We used logistic regression to evaluate the relationship between the detection of Campylobacter spp. in feces and host life traits (urban association, trophic level, and sociality).ResultsOur analysis suggest that C. jejuni transmission is associated with urban living and trophic level. The probability of carriage was highest in urban-associated species (p = 0.02793) and the most informative model included trophic level. In contrast, C. coli carriage appears to be strongly influenced by sociality (p = 0.0113) with trophic level still being important. Detection of Campylobacter organisms at the genus level, however, was only associated with trophic level (p = 0.0156), highlighting the importance of this trait in exposure dynamics across host and Campylobacter pathogen systems.DiscussionWhile many challenges remain in the detection and characterization of Camploybacter spp., these results suggest that host life traits may have important influence on pathogen exposure and transmission dynamics, providing a useful starting point for more directed surveillance approaches.
Preemptive interferon-α therapy could prevent relapse of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation: A real-world analysis
Authors: Fan Shuang , Pan Tian-Zhong , Dou Li-Ping , Zhao Yan-Min , Zhang Xiao-Hui , Xu Lan-Ping , Wang Yu , Huang Xiao-Jun , Mo Xiao-Dong 
Published: February 2023

IntroductionMeasurable residual disease (MRD)-directed interferon-a treatment (i.e. preemptive IFN-α treatment) can eliminate the MRD in patients with acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Therefore, this study aimed to further assess its efficacy in a multicenter retrospective study in a real-world setting.MethodsA total of 247 patientswho received preemptive IFN-α treatment were recruited from 4 hospitals in China. The protocols for MRD monitoring mainly based on quantitative polymerase chain reaction [qPCR] and multiparameter flow cytometry [MFC]. ResultsThe median duration of IFN-α treatment was 56 days (range, 1–1211 days). The cumulative incidences of all grades acute graft-versus-host disease (aGVHD), all grades chronic graft-versus-host disease (cGVHD), and severe cGVHD at 3 years after IFN-α therapy were 2.0% (95% confidence interval [CI], 0.3–3.8%), 53.2% (95% CI, 46.8–59.7%), and 6.2% (95% CI, 3.1–9.2%), respectively. The cumulative incidence of achieving MRD negative state at 2 years after IFN-α treatment was 78.2% (95% CI, 72.6–83.7%). The 3-year cumulative incidences of relapse and non-relapse mortality following IFN-α therapy were 20.9% (95% CI, 15.5–26.3%) and 4.9% (95%CI, 2.0–7.7%), respectively. The probabilities of leukemia-free survival and overall survival at 3 years following IFN-α therapy were 76.9% (95% CI, 71.5–82.7%) and 84.2% (95% CI, 78.7–90.1%), respectively. Multivariable analysis showed that MRD positive state by qPCR and MFC before IFN-α treatment, high-risk disease risk index before allo-HSCT, and receiving identical sibling donor HSCT were associated with a higher risk of relapse and a poorer leukemia-free survival. Severe cGVHD was associated with an increased risk of non-relapse mortality. DiscussionThus, real-world data suggest that preemptive IFN-α is effective for treating patients with AML with MRD after allo-HSCT.