bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of colorless polyimides with high Tg and low coefficient of thermal expansion from benzimidazole diamine containing biamide
Authors: Li Dongwu , Li Dandan , Ke Zhao , Gu Qian , Xu Ke , Chen Chunhai , Qian Guangtao , Liu Gang 
Published: March 2023

AbstractColorless polyimides (CPIs) with superheat resistance and low coefficient of thermal expansion (CTE) are required urgently to employ as plastic substrates in flexible‐display devices. To attain the target properties, 2‐(2‐methyl‐4‐(4‐aminobenzamido)phenyl)‐5‐(4‐aminobenzamido)‐N‐phenylbenzimidazol (AB‐MPBZ) that contains biamide was synthesized, and its homo‐ and co‐polyimides were prepared with 1,2,4,5‐cyclohexanetetracarboxylic dianhydride (HPMDA) and cyclobutane‐1,2,3,4‐tetracarboxylic dianhydride (CBDA). The crank‐shaft‐like amide groups effectively increases the linearity and stiffness of polymer segments, providing CPI films with low CTE. On the basis, the CBDA based poly(benzimidazole imide) (PBII) series with dense interchain packing exhibits further reduced CTE down to 22 ppm K−1 and increased glass‐transition temperature (Tg) up to 404 °C. Such good thermal properties indicate that the resultant copolyimides have potential applications as colorless flexible substrates. These provide a feasible approach to balance thermal and optical performance of polyimides.
Structural basis for substrate binding and catalytic mechanism of the key enzyme VioD in the violacein synthesis pathway
Authors: Xu Mengxue , Xu Dongqing , Gao Mengxiao , Zhuang Xuebo , Wang Weiwu , Sun Bo , Ran Tingting 
Published: March 2023

AbstractViolacein is a pigment synthesized by gram‐negative bacteria with various biological activities such as antimicrobial, antiviral, and anticancer activities. VioD is a key oxygenase converting protodeoxyviolaceinic acid to protoviolaceinic acid in violacein biosynthesis. To elucidate the catalytic mechanism of VioD, here, we resolved two crystal structures of VioD, a binary complex structure containing VioD and a FAD and a ternary complex structure composed of VioD, a FAD and a 2‐ethyl‐1‐hexanol (EHN). Structural analysis revealed a deep funnel like binding pocket with wide entrance, this pocket is positively charged. The EHN is located at the deep bottom of the binding pocket near isoalloxazine ring. Further docking simulation help us to propose the mechanism of the hydroxylation of the substrate catalyzed by VioD. Bioinformatic analysis suggested and emphasized the importance of the conserved residues involved in substrate binding. Our results provide a structural basis for the catalytic mechanism of VioD.
Environmental history of one of the largest freshwater neotropical fish (Zungaro jahu) from otolith isotopic analysis
Authors: Avigliano Esteban , Pouilly Marc , Vargas Facundo , Penha Jerry , Silva Natalia , Bouchez Julien , Sánchez Sebastian , Volpedo Alejandra V. 
Published: March 2023

AbstractThe ManguruyúZungaro jahu, endemic to the La Plata Basin, is one of the largest neotropical fish species whose life history is virtually unknown. The objectives of this study were to determine ifZ. jahuis a large‐scale migratory species and to describe habitat use throughout ontogeny using the otolith Sr isotope (87Sr/86Sr) ratio. Surface water samples were collected in 2020 at four sites representing the main water courses of the Great Pantanal in Brazil (upper Paraguay, Cuiabá, São Lourenço and Vermelho rivers). Eighteen fish individuals were collected from the Paraná River (Argentina). New water87Sr/86Sr data were incorporated into previously established statistical models to infer the fish habitat use through the otolith87Sr/86Sr ratios. The water87Sr/86Sr ratio of the upper Paraguay tributaries varied (0.7209 and 0.7229) and were the highest in the La Plata Basin. The dispersal area ofZ. jahuwas restricted to the surroundings of the confluence of the Paraná and Paraguay rivers. Fish showed chemical signatures compatible with those of the middle Paraná (88%), Paraguay‐Pilcomayo‐Bermejo (50%) and the lower/upper Paraná (66%). The discriminant analysis based on otolith core indicated natal origins from the middle Paraná (37%), upper Paraná (32%), and Paraguay sub‐basin (32%). The dispersal area ofZ. jahumigrations could be restricted to the surroundings of the confluence of Paraná and Paraguay, which highlights the need to review regional fishing regulations, especially between latitudes 30°–34° S.
Green climate and pro‐environmental behavior: Addressing attitude‐behavior gaps towards promoting sustainable development
Authors: Zhang Yan , Du Jiangguo , Boamah Kofi Baah 
Published: March 2023

AbstractBased on the Stimulus‐Organism‐Response theory, this paper extends knowledge by examining both the direct and indirect effect of green climate on pro‐environmental behavior whilst incorporating the following two multidimensional measures: group identification and social norm measure as mediator and moderator, respectively. The study extends current knowledge by addressing the attitude‐behavior gaps eminent in most papers. Consequently, this study provides in depth knowledge on the mechanisms underpinning the role of individuals and also their role as influenced by the group they belong to. Further, this study proffer knowledge from the perspective of both private and public sphere pro‐environmental behavior. The present study employed structural equation modeling using a survey from a dataset of 836 respondents. The findings revealed that green climate positively influence public‐sphere behavior. Further, green climate indirectly affects private‐sphere behavior through group identification. Again, our study found that group identification partially mediates the relationship between green climate and public‐sphere behavior. The theoretical and practical implications of these findings are further discussed.
Amoeba‐Inspired Magnetic Venom Microrobots
Authors: Zhang Weiwei , Deng Yuguo , Zhao Jinhao , Zhang Tao , Zhang Xiang , Song Wenping , Wang Lin , Li Tianlong 
Published: March 2023

AbstractNature provides a successful evolutionary direction for single‐celled organisms to solve complex problems and complete survival tasks – pseudopodium. Amoeba, a unicellular protozoan, can produce temporary pseudopods in any direction by controlling the directional flow of protoplasm to perform important life activities such as environmental sensing, motility, predation, and excretion. However, creating robotic systems with pseudopodia to emulate environmental adaptability and tasking capabilities of natural amoeba or amoeboid cells remains challenging. Here, this work presents a strategy that uses alternating magnetic fields to reconfigure magnetic droplet into Amoeba‐like microrobot, and the mechanisms of pseudopodia generation and locomotion are analyzed. By simply adjusting the field direction, microrobots switch in monopodia, bipodia, and locomotion modes, performing all pseudopod operations such as active contraction, extension, bending, and amoeboid movement. The pseudopodia endow droplet robots with excellent maneuverability to adapt to environmental variations, including spanning 3D terrains and swimming in bulk liquids. Inspired by the “Venom,” the phagocytosis and parasitic behaviors have also been investigated. Parasitic droplets inherit all the capabilities of amoeboid robot, expanding their applicable scenarios such as reagent analysis, microchemical reactions, calculi removal, and drug‐mediated thrombolysis. This microrobot may provide fundamental understanding of single‐celled livings, and potential applications in biotechnology and biomedicine.
Lithiophilic Magnetic Host Facilitates Target‐Deposited Lithium for Practical Lithium‐Metal Batteries
Authors: Zhou Shuang , Meng Xinyu , Fu Chunyan , Chen Jing , Chen Yining , Xu Dongming , Lin Shangyong , Han Chao , Chang Zhi , Pan Anqiang 
Published: March 2023

AbstractLithium‐metal shows promising prospects in constructing various high‐energy‐density lithium‐metal batteries (LMBs) while long‐lasting tricky issues including the uncontrolled dendritic lithium growth and infinite lithium volume expansion seriously impede the application of LMBs. In this work, it is originally found that a unique lithiophilic magnetic host matrix (Co3O4‐CCNFs) can simultaneously eliminate the uncontrolled dendritic lithium growth and huge lithium volume expansion that commonly occur in typical LMBs. The magnetic Co3O4 nanocrystals which inherently embed on the host matrix act as nucleation sites and can also induce micromagnetic field and facilitate a targeted and ordered lithium deposition behavior thus, eliminating the formation of dendritic Li. Meanwhile, the conductive host can effectively homogenize the current distribution and Li‐ion flux, thus, further relieving the volume expansion during cycling. Benefiting from this, the featured electrodes demonstrate ultra‐high coulombic efficiency of 99.1% under 1 mA cm−2 and 1 mAh cm−2. Symmetric cell under limited Li (10 mAh cm−2) inspiringly delivers ultralong cycle life of 1600 h (under 2 mA cm−2, 1 mAh cm−2). Moreover, LiFePO4||Co3O4‐CCNFs@Li full‐cell under practical condition of limited negative/positive capacity ratio (2.3:1) can deliver remarkably improved cycling stability (with 86.6% capacity retention over 440 cycles).
High‐Performance Integrated Iontronic Circuits Based on Single Nano/Microchannels
Authors: Li Jun , Li Mengqi , Zhang Kaiping , Hu Lide , Li Dongqing 
Published: March 2023

AbstractRecently, artificial channel‐based ionic diodes and transistors are extensively studied to mimic biological systems. Most of them are constructed vertically and are challenging to be further integrated. Several examples of ionic circuits with horizontal ionic diodes are reported. However, they generally require nanoscale channel sizes to meet the demand for ion‐selectivity, resulting in low current output and restricting potential applications. In this paper, a novel ionic diode is developed based on multiple‐layer polyelectrolyte nanochannel network membranes. Both bipolar and unipolar ionic diodes can be achieved by simply switching the modification solution. Ionic diodes with a high rectification ratio of ≈226 are achieved in single channels with the largest channel size of 2.5 µm. This design can significantly reduce the channel size requirement and improve the output current level of ionic devices. The high‐performance ionic diode with a horizontal structure enables the integration of advanced iontronic circuits. Ionic transistors, logic gates, and rectifiers are fabricated on a single chip and demonstrated for current rectification. Furthermore, the excellent current rectification ratio and the high output current of the on‐chip ionic devices highlight the promise of the ionic diode as a component of complex iontronic systems for practical applications.
Meniscus‐Guided Deposition of Organic Semiconductor Thin Films: Materials, Mechanism, and Application in Organic Field‐Effect Transistors
Authors: Ren Chunxing , Cao Long , Wu Ti 
Published: March 2023

AbstractSolution‐processable organic semiconductors are one of the promising materials for the next generation of organic electronic products, which call for high‐performance materials and mature processing technologies. Among many solution processing methods, meniscus‐guided coating (MGC) techniques have the advantages of large‐area, low‐cost, adjustable film aggregation, and good compatibility with the roll‐to‐roll process, showing good research results in the preparation of high‐performance organic field‐effect transistors. In this review, the types of MGC techniques are first listed and the relevant mechanisms (wetting mechanism, fluid mechanism, and deposition mechanism) are introduced. The MGC processes are focused and the effect of the key coating parameters on the thin film morphology and performance with examples is illustrated. Then, the performance of transistors based on small molecule semiconductors and polymer semiconductor thin films prepared by various MGC techniques is summarized. In the third section, various recent thin film morphology control strategies combined with the MGCs are introduced. Finally, the advanced progress of large‐area transistor arrays and the challenges for roll‐to‐roll processes are presented using MGCs. Nowadays, the application of MGCs is still in the exploration stage, its mechanism is still unclear, and the precise control of film deposition still needs experience accumulation.
Tuning the Trade‐Off between Ethane/Ethylene Selectivity and Adsorption Capacity within Isoreticular Microporous Metal−Organic Frameworks by Linker Fine‐Fluorination
Authors: Yu Mei‐Hui , Fang Han , Huang Hong‐Liang , Zhao Meng , Su Zheng‐Yu , Nie Hong‐Xiang , Chang Ze , Hu Tong‐Liang 
Published: March 2023

AbstractThe pore dimension and surface property directly dictate the transport of guests, endowing diverse gas selective adsorptions to porous materials. It is highly relevant to construct metal−organic frameworks (MOFs) with designable functional groups that can achieve feasible pore regulation to improve their separation performances. However, the role of functionalization in different positions or degrees within framework on the separation of light hydrocarbon has rarely been emphasized. In this context, four isoreticular MOFs (TKL‐104−107) bearing dissimilar fluorination are rationally screened out and afforded intriguing differences in the adsorption behavior of C2H6 and C2H4. Ortho‐fluoridation of carboxyl allows TKL‐105−107 to exhibit enhanced structural stabilities, impressive C2H6 adsorption capacities (>125 cm3 g−1) and desirable inverse selectivities (C2H6 over C2H4). The more modified ortho‐fluorine group and meta‐fluorine group of carboxyl have improved the C2H6/C2H4 selectivity and adsorption capacity, respectively, and the C2H6/C2H4 separation potential can be well optimized via linker fine‐fluorination. Meanwhile, dynamic breakthrough experiments proved that TKL‐105−107 can be used as highly efficient C2H6‐selective adsorbents for C2H4 purification. This work highlights that the purposeful functionalization of pore surfaces facilitates the assembly of highly efficient MOF adsorbents for specific gas separation.
Technical debt (TD) through the lens of Twitter: A survey
Authors: Alfayez Reem , Winn Robert , Ding Yunyan , Alfayez Ghaida , Boehm Barry 
Published: March 2023

AbstractTechnical debt (TD) is a metaphor used to refer to the added software system costs acquired from taking shortcuts. Unfortunately, large amounts of TD can lead to serious consequences, and, thus, the management of TD is essential. Due to TD being a relatively new subject of study, many aspects of TD remain ambiguous. Fortunately, Twitter has been proven to hold a wealth of information on many subjects. As such, this survey study aims to gain a better understanding on how interest in TD has evolved over time and how TD is addressed on Twitter. A total of 128,897 TD‐related tweets were scrapped from Twitter and analyzed using a number of proxy measures and Latent Dirichlet Allocation (LDA). The results revealed that interest in TD on Twitter has been generally increasing since the platform's early stages. Furthermore, TD‐related tweets were found to revolve around 11 distinct categories. The TD in games category was discovered to be the most popular category, followed by TD communication and TD repayment. The results highlight that TD is a diverse and overarching topic that contains many potential avenues for further exploration. Software engineering researchers, practitioners, and educators can utilize this study to help steer their TD‐related future efforts.
Rough Nanovaccines Boost Antitumor Immunity Through the Enhancement of Vaccination Cascade and Immunogenic Cell Death Induction
Authors: Zhao Xiaoyi , Zhang Jiatong , Chen Beibei , Ding Xiaokang , Zhao Nana , Xu Fu‐Jian 
Published: March 2023

AbstractNanovaccines have attracted intense interests for efficient antigen delivery and tumor‐specific immunity. It is challenging to develop a more efficient and personalized nanovaccine to maximize all steps of the vaccination cascade by exploiting the intrinsic properties of nanoparticles. Here, biodegradable nanohybrids (MP) composed of manganese oxide nanoparticles and cationic polymers are synthesized to load a model antigen ovalbumin to form MPO nanovaccines. More interestingly, MPO could serve as autologous nanovaccines for personalized tumor treatment taking advantage of in situ released tumor‐associated antigens induced by immunogenic cell death (ICD). The intrinsic properties of MP nanohybrids including morphology, size, surface charge, chemical, and immunoregulatory functions are fully exploited to enhance of all steps of the cascade and induce ICD. MP nanohybrids are designed to efficiently encapsulate antigens by cationic polymers, drain to lymph nodes by appropriate size, be internalized by dendritic cells (DCs) by rough morphology, induce DC maturation through cGAS‐STING pathway, and enhance lysosomal escape and antigen cross‐presentation through the “proton sponge effect”. The MPO nanovaccines are found to efficiently accumulate in lymph nodes and elicit robust specific T‐cell immune responses to inhibit the occurrence of ovalbumin‐expressing B16‐OVA melanoma. Furthermore, MPO demonstrate great potential to serve as personalized cancer vaccines through the generation of autologous antigen depot through ICD induction, activation of potent antitumor immunity, and reversal of immunosuppression. This work provides a facile strategy for the construction of personalized nanovaccines by exploiting the intrinsic properties of nanohybrids.
Liquid chromatographic methods for simultaneous quantification of fixed‐dose combinations of pantoprazole with itopride and ondansetron: Application to method greenness assessment
Authors: Panda Sagar Suman , Panigrahi Subham , Mohanty Sonal , Bera Ravi Kumar Venkata Varaha , Mekap Suman Kumar 
Published: March 2023

AbstractTwo liquid chromatography methods are developed to quantify pantoprazole and its fixed‐dose counterparts, itopride hydrochloride, and ondansetron. The basic chromatography utilized a C‐18 column (150 × 4.6 mm × 5 μm) with a simple mobile phase of methanol: 0.01 M potassium dihydrogen phosphate buffer of pH 3.5 (80:20 v/v) with a flow rate of 1.0 ml/min. The diode array detections were performed at 273 nm (Method‐I) and 280 nm (Method‐II). The validation of parameters like linearity (R2 > 0.99), accuracy (98%–103%), precision (≤1 %), system suitability, and so forth, was found satisfactory for both methods. A risk estimation approach helped sort out method variables methanol%, pH, and flow rate and highlighted their influence on the method's robustness. The developed methods aptly quantified all the target analytes with the maximum possible recovery from combined pharmaceuticals. Assessment of the method greenness profile revealed excellent method greenness with maximal green shades in a pictogram and a greenness score of 89. The developed analytical methods are green and befitting for routine quality control of two widely used fixed‐dose combinations of pantoprazole.
On the Integral Representation and the Raşa, Jensen and Hermite–Hadamard Inequalities for Box-Convex Functions
Authors: Komisarski Andrzej , Rajba Teresa 
Published: March 2023

AbstractWe give the integral representation of Popoviciu’s (Mathematica 8:1–85, 1934) box-(m, n)-convex functions. Based on this integral representation, we obtain a characterization of box-(m, n)-convex orders, which we then use in the proofs of the Raşa type, the Hermite–Hadamard type and the Jensen inequalities for box-(m, n)-convex functions as well as for strongly box-(m, n)-convex functions. We extend the results obtained by Gal and Niculescu (J Math Anal Appl 479:903–925, 2019), and by Gavrea and Gavrea (Mediterr J Math 19:18–33, 2022).
Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells
Authors: Gohara Yuma , Tomonobu Nahoko , Kinoshita Rie , Futami Junichiro , Audebert Léna , Chen Youyi , Komalasari Ni Luh Gede Yoni , Jiang Fan , Yoshizawa Chikako , Murata Hitoshi , Yamamoto Ken-ichi , Watanabe Masami , Kumon Hiromi , Sakaguchi Masakiyo 
Published: March 2023

Abstract
The adenovirus-REIC/Dkk-3 expression vector (Ad-REIC) has been the focus of numerous clinical studies due to its potential for the quenching of cancers. The cancer-suppressing mechanisms of the REIC/DKK-3 gene depend on multiple pathways that exert both direct and indirect effects on cancers. The direct effect is triggered by REIC/Dkk-3-mediated ER stress that causes cancer-selective apoptosis, and the indirect effect can be classified in two ways: (i) induction, by Ad-REIC-mis-infected cancer-associated fibroblasts, of the production of IL-7, an important activator of T cells and NK cells, and (ii) promotion, by the secretory REIC/Dkk-3 protein, of dendritic cell polarization from monocytes. These unique features allow Ad-REIC to exert effective and selective cancer-preventative effects in the manner of an anticancer vaccine. However, the question of how the REIC/Dkk-3 protein leverages anticancer immunity has remained to be answered. We herein report a novel function of the extracellular REIC/Dkk-3—namely, regulation of an immune checkpoint via modulation of PD-L1 on the cancer-cell surface. First, we identified novel interactions of REIC/Dkk-3 with the membrane proteins C5aR, CXCR2, CXCR6, and CMTM6. These proteins all functioned to stabilize PD-L1 on the cell surface. Due to the dominant expression of CMTM6 among the proteins in cancer cells, we next focused on CMTM6 and observed that REIC/Dkk-3 competed with CMTM6 for PD-L1, thereby liberating PD-L1 from its complexation with CMTM6. The released PD-L1 immediately underwent endocytosis-mediated degradation. These results will enhance our understanding of not only the physiological nature of the extracellular REIC/Dkk-3 protein but also the Ad-REIC-mediated anticancer effects.

Key messages
• REIC/Dkk-3 protein effectively suppresses breast cancer progression through an acceleration of PD-L1 degradation.
• PD-L1 stability on the cancer cell membrane is kept high by binding with mainly CMTM6.
• Competitive binding of REIC/Dkk-3 protein with CMTM6 liberates PD-L1, leading to PD-L1 degradation.
Replication casting and additive manufacturing for fabrication of cellular aluminum with periodic topology: optimization by CFD simulation
Authors: Fernández-Morales Patricia , Echeverrí Lauramaría , Fandiño Emigdio Mendoza , Zuleta Gil Alejandro Alberto 
Published: March 2023

Abstract
In this work, processes such as additive digital manufacturing (ADM) and precision casting are presented as alternative methods to manufacture aluminum foams with ordered open-pore morphology. Digital modeling of cellular structures with defined regular patterns was manufactured with ABS and wax and then melted in aluminum A356 alloy by a replication casting process. To guarantee the complete filling of the mold, a simulation by the Flow-3D program was made. This computational tool allowed to determine the temperature values of both melting and the mold temperature. The simulations revealed potential defects in the metal foams to be obtained, which were evidenced by the cast pieces processed after as a validation test. The results show that the casting process carried out supported by a computational fluid dynamics (CFD) simulation allows understanding the effects of the simulated parameter process, optimizing the parameters involved in the infiltration process, and establishing the conditions for obtaining a sound piece of open-cell aluminum foam with truncated octahedron pores shape. The established manufacturing process conditions can be used to produce lattice structures with multifunctional uses such as impact and blast-proof devices, vibration attenuators, or where enhancement of heat transfer could be needed.