bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of myocardial ischemia in coronary heart disease patients using a CCTA–Based radiomic nomogram
Authors: Yang You-Chang , Dou Yang , Wang Zhi-Wei , Yin Ruo-Han , Pan Chang-Jie , Duan Shao-Feng , Tang Xiao-Qiang 
Published: January 2023

ObjectiveThe present study aimed to predict myocardial ischemia in coronary heart disease (CHD) patients based on the radiologic features of coronary computed tomography angiography (CCTA) combined with clinical factors.MethodsThe imaging and clinical data of 110 patients who underwent CCTA scan before DSA or FFR examination in Changzhou Second People’s Hospital, Nanjing Medical University (90 patients), and The First Affiliated Hospital of Soochow University (20 patients) from March 2018 to January 2022 were retrospectively analyzed. According to the digital subtraction angiography (DSA) and fractional flow reserve (FFR) results, all patients were assigned to myocardial ischemia (n = 58) and normal myocardial blood supply (n = 52) groups. All patients were further categorized into training (n = 64) and internal validation (n = 26) sets at a ratio of 7:3, and the patients from second site were used as external validation. Clinical indicators of patients were collected, the left ventricular myocardium were segmented from CCTA images using CQK software, and the radiomics features were extracted using pyradiomics software. Independent prediction models and combined prediction models were established. The predictive performance of the model was assessed by calibration curve analysis, receiver operating characteristic (ROC) curve and decision curve analysis.ResultsThe combined model consisted of one important clinical factor and eight selected radiomic features. The area under the ROC curve (AUC) of radiomic model was 0.826 in training set, and 0.744 in the internal validation set. For the combined model, the AUCs were 0.873, 0.810, 0.800 in the training, internal validation, and external validation sets, respectively. The calibration curves demonstrated that the probability of myocardial ischemia predicted by the combined model was in good agreement with the observed values in both training and validation sets. The decision curve was within the threshold range of 0.1–1, and the clinical value of nomogram was higher than that of clinical model.ConclusionThe radiomic characteristics of CCTA combined with clinical factors have a good clinical value in predicting myocardial ischemia in CHD patients.
Dynamic evolution of changbaishan volcanism in Northeast China illuminated by machine learning
Authors: Zhao Yong , Zhang Yigang , Ni Dongdong 
Published: January 2023

Previous studies propose that there is a mantle upwelling that generated the Cenozoic basalts in Changbaishan. However, the dominant source and mechanism of the mantle upwelling remains highly debated. Here we apply machine learning algorithms of Random Forest and Deep Neural Network to train models using global island arc and ocean island basalts data. The trained models predict that Changbaishan basalts are highly influenced by slab-derived fluid. More importantly, the fluid effect decreases with no (87Sr/86Sr)0 and εNd(t) changes between 5 Ma and 1 Ma, then enhances with increasing εNd(t) and decreasing (87Sr/86Sr)0 after 1 Ma. We propose that a gap opened at about 5 Ma and the hot sub-slab oceanic asthenosphere rose through the gap after 1 Ma, generating the basalts enriched in fluid mobile elements and with the addition of depleted mantle component derived from the sub-slab oceanic asthenosphere.
Experimental method and application of the slurry “diffusion-bleeding-seepage” of isolated overburden grout injection
Authors: Wang Chaochao , Xu Jialin , Xuan Dayang , Li Jian 
Published: January 2023

Isolated overburden grout injection (IOGI) is a green mining method to control surface subsidence. Slurry water significantly influences grouting effectiveness and mining safety. This study establishes a three-dimensional visualization experimental system for slurry “diffusion-bleeding-seepage” to investigate the seepage law of slurry water. The system is composed primarily of a transparent box (1.2 m × 0.5 m × 0.25 m) and support, with the solid–liquid coupling seepage similar material and modules for mining, grouting injection, slurry pressure and displacement monitoring, overburden saturation monitoring, and water leakage monitoring of the working face. A similar material with good permeability and non-disintegration is obtained by hydrophilic, water absorption, and permeability tests. Grouting and mining are simulated by pulling acrylic sheets and pumping slurry. With the fly ash slurry entering the injection layer, the slurry undergoes water–cement separation, and the water bleeding is formed to seep into the similar material. The volumetric water content of the similar material is obtained by arranging multiple groups of volumetric water content sensors into the similar material. The corresponding saturation is obtained by theoretical calculation. The experimental system is used to simulate the seepage of slurry water in a high initial saturation overburden, and the characteristics of injection slurry diffusion and water bleeding are obtained. The profile distribution of seepage of slurry water is found to possess a semi-elliptical shape. Under the condition of high initial saturation, slurry water appears in the working face. The system provides a convenient method for further research of IOGI slurry water seepage.
Geochemistry, zircon U-Pb age and Hf isotope for the Huatugou granitoid in western Qaidam: Petrogenesis and tectonic implications
Authors: Teng Xia , Zhang Jianxin , Mao Xiaohong , Wu Yawei , Guo Qi 
Published: January 2023

The Qaidam Precambrian block is located in the northeastern Tibetan Plateau and was intruded by numerous Ordovician-Devonian granitoids during and after the closure of the Proto-Tethys Ocean. In the past 20 years, the granitoids within early Paleozoic subduction-collision belts have been investigated in detail. However, the granitoids intruding the inner part of the Qaidam block, bearing the tectonic significance for the whole block, still need to be understood. This study presents new whole-rock geochemical and zircon U-Pb-Hf isotopic data for the Huatugou granitoids in the Qaidam Precambrian block. The investigated granitoids include granodiorite, monzogranite, biotite granite, and muscovite granite, which intruded the Precambrian basements during 451–400 Ma. The granodiorites (451 ± 6 Ma) display adakitic geochemical features and syn-tectonic textures, and their magmas were generated by the partial melting of the lower mafic crust within a thickened continent. The muscovite granites (410 ± 6 Ma), with negative zircon εHf(t) values of −14.5 to −10.4, were crystallized from fractionated S-type magmas, which were derived from the partial melting of ancient crustal materials. The biotite granite (410 ± 3 Ma) and monzogranites (400 ± 4 Ma) are high-temperature A2-type granites. The biotite granite displays positive zircon εHf(t) values of +1.7 to +5.6. Its magma was generated by the high-temperature partial melting of juvenile crustal rocks in a thinned lower crust. The monzogranites exhibit higher SiO2 contents and lower εHf(t) values, and their magmas were derived from the same source but underwent assimilation and fractional crystallization during emplacement. From the thickened to the thinned continent during 451–410 Ma, the western Qaidam block experienced a tectonic transition from compression to extension. Combined with regional geological data, this study suggests that the Qaidam block consisted of the thickened continental crust during subduction processes until the detachment of the subducted slab during the continental collision. The regional extension of the Qaidam block commenced at ∼420 Ma, soon after the exhumation of ultrahigh-pressure metamorphic rocks within the northern Qaidam subduction-collision complex belt.
Multiscale mechanical characterizations of ultrafine tailings mixed with incineration slag
Authors: Jing Xiaofei , Wu Shangwei , Qin Jia , Li Xiaoshuang , Liu Xiaohua , Zhang Yuanzhen , Mao Jingxin , Nie Wen 
Published: January 2023

Adding a type of municipal solid waste (incinerator slag) into ultrafine tailings can effectively enhance the mechanical properties of tailings. With an aim to study the macro- and micro-mechanical properties of the tailings slag mixture (TSM), the strength parameters (internal friction angle, cohesion) and micro-mechanical properties with different slag contents were analyzed by geotechnical experiments and particle flow simulations, respectively. The macroscale experimental results demonstrated that the strength parameters of TSM were much higher than that of tailings. Strength parameters also showed non-linear-rising trends with increasing slag content. For the slag content of 40%, the maximum cohesiveness of TSM was determined at 65.2 kPa, and the corresponding friction angle was 39.9°C. Furthermore, the Particle Flow Code (PFC) micro-simulation software was used to analyze the micro-mechanical characteristics of the TSM at different slag contents. The microscale simulation outcomes indicated that the particle transport, particularly in their moving directions, became increasingly chaotic with an increase in the slag content; also, the slag particles significantly impacted the shear processing zone of the TSM. These experimental and numerical results brought more scientific insights into the shear failure mechanism of TSM.
Individual patient-centered target-driven intervention to improve clinical outcomes of diabetes, health literacy, and self-care practices in Nepal: A randomized controlled trial
Authors: Pardhan Shahina , Upadhyaya Tirthalal , Smith Lee , Sharma Tara , Tuladhar Sarita , Adhikari Bhojraj , Kidd John , Sapkota Raju 
Published: January 2023

PurposeTo examine the effectiveness of a culturally and linguistically appropriate, patient-centered, target-driven lifestyle intervention with video education training in improving clinical outcomes, health literacy, and diabetic self-care practices in newly diagnosed patients in Nepal.MethodsA total of 110 participants with newly and consequently diagnosed Type 2 were randomly allocated into intervention (mean age = 45 ± 9.7 years) and control (mean age = 47 ± 12.5 years) groups. Intervention group participants were trained on a culturally and linguistically appropriate diabetic video education program and were given a customized dietary and physical activity plan with specific targets to practice at home. Participants’ compliance was monitored weekly via telephone calls. Both groups received the usual treatment from their doctor and were followed up after three months. Outcome measures included changes in: i. diabetic health literacy, diet, and physical activity measured using self-reported questionnaires; and ii. blood glucose (glycated hemoglobin, HbA1c), cholesterol, blood pressure, body mass index, and visual acuity. Clinical outcome measures were blinded from randomization and intervention allocation.ResultsAfter three months, HbA1c decreased to 6.1% from the baseline value of 7.2% in the intervention group compared to 6.6% in the control group from the baseline value of 7.1% (p &lt;0.05). The intervention group had mean total cholesterol and low-density lipoprotein of 174 and 95.5 mg/dL, which were significantly lower than 186 and 107.5 mg/dL in the control group. Daily white rice consumption decreased by 36.5% in the intervention vs. 4% in the control group (p &lt;0.05). After three months, the intervention group participants exercised more than the control group (p &lt;0.05). All intervention group participants self-initiated retinal screening checks since the baseline visit among which 13% showed early diabetic retinopathy signs compared to 0% in the control group. Health literacy improvement in the intervention group was found to be sustained after three months too.ConclusionsA culturally appropriate, target-driven lifestyle intervention with video education training is effective in improving clinical outcomes, health literacy, and self-care practice in newly diagnosed diabetic patients in Nepal, i.e., at a time period when effective diabetes control is vital to prevent further complications. The training intervention could be rolled out nationwide in order to reduce the risk of diabetic-related complications and improve people’s quality of life and productivity.
Photocatalytic degradation of glyphosate using Ce/N co-doped TiO2 with oyster shell powder as carrier under the simulated fluorescent lamp
Authors: Zhang Wei , You Qizheng , Shu Jinkai , Wang Aihe , Lin Hai , Yan Xuchao 
Published: January 2023

Glyphosate is currently one of the most used organophosphorus herbicides in the world and its accumulation and translocation in soil and wave causes environmental pollution and biological health problems. A new approach to the problem is provided by the preparation of cerium and nitrogen co-doped titanium dioxide composite nano-photocatalysts loaded on modified oyster shell powder (CeNT@Oys) by a simple hydrothermal synthesis. The physicochemical and optoelectronic properties are analyzed using SEM, BET, XRD, Raman, FTIR, UV-vis DRS, XPS characterization techniques and a range of photoelectrochemical techniques. The results show that the addition of modified oyster shell powder increases its specific surface area, while Ce-N-TiO2 is an anatase crystal composed of Ce doped in the form of interstitial and surface, interstitial form of N, and the co-doping of Ce and N elements gives it the property of being excited by visible light. The photocatalytic activity of the different catalysts was evaluated by degrading 50 mg/L glyphosate solution under simulated sunlight. The catalyst was determined to be reusable by five repeated degradation experiments. Based on quenching experiments and the electron paramagnetic resonance tests, the effective active species of glyphosate degraded by the catalyst was determined and the mechanism of glyphosate degradation by photocatalyst was proposed. Finally, the degradation pathway for the photocatalytic degradation of PMG by CeNT@Oys was determined by HPLC-MS/MS determine of the intermediate products.
A rare case report of waldenström macroglobulinemia converted to serum low IgM
Authors: Xiang Yuan , Fang Shi-Qiang , Liu Yi-Wen , Wang Hui , Lu Zhong-Xin 
Published: January 2023

Waldenström Macroglobulinemia (WM) is a rare chronic lymphoproliferative disease, accounting for less than 2% of hematological malignancies. It is characterized by plasma cytoid lymphocyte infiltration in bone marrow and abnormal increase of monoclonal IgM in peripheral blood. Only 5%–10% of cases of WM secrete monoclonal IgG and IgA components or do not secrete monoclonal long immunoglobulin. This case is the first to report of serum protein recombination from lgM and Igkappa band mutation to abnormal lgG and Igkappa band after 6 years of treatment in a male patient with WM.
Longitudinal monitoring of mRNA-vaccine-induced immunity against SARS-CoV-2
Authors: Monzon-Posadas Werner O. , Zorn Jasmin , Peters Kathrin , Baum Maximilian , Proksch Hannah , Schlüter Celina Beta , Menting Tanja , Pušnik Jernej , Streeck Hendrik 
Published: January 2023

BackgroundWorldwide vaccination campaigns significantly reduced mortality caused by SARS-CoV-2 infection and diminished the devastating effects of the pandemic. The first approved vaccines are based on novel mRNA technology and elicit potent immune responses offering high levels of protection from severe disease.MethodsHere we longitudinally assessed adaptive immune responses during a 12-month follow-up period after the initial immunization with 2 doses of mRNA vaccines and after the booster dose in blood and saliva.ResultsOur findings demonstrate a rapid waning of the anti-spike IgG titers between months 3 and 6 after the initial vaccination (1.7- and 2.5-fold decrease in plasma and saliva, respectively; P&lt;0.0001). Conversely, the frequency of spike-specific memory B cells increased during this period (2.4-fold increase; P&lt;0.0001) while the frequency of spike-specific CD4+ and CD8+ T cells remained stable for all assessed functions: cytotoxicity, IFNγ, IL-2, and TNFα expression. Booster vaccination significantly improved the antibody response in plasma and saliva, with the most profound changes observed in the neutralization capacity against the currently circulating omicron variant (25.6-fold increase; P&lt;0.0001). The positive effect of booster vaccination was also evident for spike-specific IgG+ memory B cell (2.4-fold increase; P&lt;0.0001) and cytotoxic CD4+ and CD8+ T cell responses (1.7- and 1.9-fold increase respectively; P&lt;0.05).ConclusionsCollectively, our findings offer a detailed insight into the kinetics of adaptive immune response following SARS-CoV-2 vaccination and underline the beneficial effects of a booster vaccination.
Using fishers’ knowledge to determine the spatial extent of deep-water spawning of capelin (Mallotus villosus) in Newfoundland, Canada
Authors: Bliss Laura M. , Dawe Natalya , Carruthers Erin H. , Murphy Hannah M. , Davoren Gail K. 
Published: January 2023

IntroductionOn the Newfoundland-Labrador Shelf, Canada, capelin (Mallotus villosus) is a key forage fish that migrates annually from offshore to spawn within coastal embayments. Although capelin are thought to primarily spawn on beaches in this region, they also spawn subtidally in deeper water (5–40 m), where their eggs remain throughout incubation. The spatial extent of subtidal (i.e. “deep-water”) spawning habitat in coastal Newfoundland is unknown and is a research priority for fishers and management.MethodsWe collaborated with capelin fishers to identify putative deep-water spawning sites as a first step in determining the contribution of deep-water spawning to capelin recruitment. Given limited fine-scale coastal bathymetry and seabed habitat type data, which impeded spatial modeling to determine suitable capelin spawning habitat, this science-industry research collaboration was key to addressing this knowledge gap.ResultsThrough two years of multi-bay fisher interviews, 84% of interviewed fishers (56 interviewees) reported having observed deep-water spawning and identified a broad distribution of putative spawning sites throughout coastal Newfoundland. The majority of fishers indicated inter-annual variation in beach and deep-water spawning habitat use, and most interviewees linked this variation to temperature and capelin abundance. Further collaborations with fishers during boat-based surveys, we sampled 136 unique sites within 12 search areas in eastern Placentia Bay and 26 unique sites within six search areas in Bonavista Bay. Underwater video surveys combined with sediment sampling revealed seven previously undocumented deep-water spawning sites.ConclusionThe deep-water spawning areas derived from these fisher interviews can now be used to build a time series for monitoring capelin spawning habitat use alongside citizen-based beach monitoring data, as a general capelin stock health indicator in a weight of evidence approach for the science advisory process.
MRI-derived radiomics to guide post-operative management of glioblastoma: Implication for personalized radiation treatment volume delineation
Authors: Chiesa S. , Russo R. , Beghella Bartoli F. , Palumbo I. , Sabatino G. , Cannatà M. C. , Gigli R. , Longo S. , Tran H. E. , Boldrini L. , Dinapoli N. , Votta C. , Cusumano D. , Pignotti F. , Lupattelli M. , Camilli F. , Della Pepa G. M. , D’Alessandris G. Q. , Olivi A. , Balducci M. , Colosimo C. , Gambacorta M. A. , Valentini V. , Aristei C. , Gaudino S. 
Published: January 2023

BackgroundThe glioblastoma’s bad prognosis is primarily due to intra-tumor heterogeneity, demonstrated from several studies that collected molecular biology, cytogenetic data and more recently radiomic features for a better prognostic stratification. The GLIFA project (GLIoblastoma Feature Analysis) is a multicentric project planned to investigate the role of radiomic analysis in GB management, to verify if radiomic features in the tissue around the resection cavity may guide the radiation target volume delineation.Materials and methodsWe retrospectively analyze from three centers radiomic features extracted from 90 patients with total or near total resection, who completed the standard adjuvant treatment and for whom we had post-operative images available for features extraction. The Manual segmentation was performed on post gadolinium T1w MRI sequence by 2 radiation oncologists and reviewed by a neuroradiologist, both with at least 10 years of experience. The Regions of interest (ROI) considered for the analysis were: the surgical cavity ± post-surgical residual mass (CTV_cavity); the CTV a margin of 1.5 cm added to CTV_cavity and the volume resulting from subtracting the CTV_cavity from the CTV was defined as CTV_Ring. Radiomic analysis and modeling were conducted in RStudio. Z-score normalization was applied to each radiomic feature. A radiomic model was generated using features extracted from the Ring to perform a binary classification and predict the PFS at 6 months. A 3-fold cross-validation repeated five times was implemented for internal validation of the model.ResultsTwo-hundred and seventy ROIs were contoured. The proposed radiomic model was given by the best fitting logistic regression model, and included the following 3 features: F_cm_merged.contrast, F_cm_merged.info.corr.2, F_rlm_merged.rlnu. A good agreement between model predicted probabilities and observed outcome probabilities was obtained (p-value of 0.49 by Hosmer and Lemeshow statistical test). The ROC curve of the model reported an AUC of 0.78 (95% CI: 0.68–0.88).ConclusionThis is the first hypothesis-generating study which applies a radiomic analysis focusing on healthy tissue ring around the surgical cavity on post-operative MRI. This study provides a preliminary model for a decision support tool for a customization of the radiation target volume in GB patients in order to achieve a margin reduction strategy.
Conventional and three-dimensional photography as a tool to map distribution patterns of in-transit melanoma metastases on the lower extremity
Authors: Müller Kilian , Berking Carola , Voskens Caroline , Heppt Markus V. , Heinzerling Lucie , Koch Elias A. T. , Kramer Rafaela , Merkel Susanne , Schuler-Thurner Beatrice , Schellerer Vera , Steeb Theresa , Wessely Anja , Erdmann Michael 
Published: January 2023

BackgroundIn melanoma, in-transit metastases characteristically occur at the lower extremity along lymphatic vessels.ObjectivesThe objective of this study was to evaluate conventional or three-dimensional photography as a tool to analyze in-transit metastasis pattern of melanoma of the lower extremity. In addition, we assessed risk factors for the development of in-transit metastases in cutaneous melanoma.MethodsIn this retrospective, monocentric study first we compared the clinical data of all evaluable patients with in-transit metastases of melanoma on the lower extremity (n = 94) with melanoma patients without recurrence of disease (n = 288). In addition, based on conventional (n = 24) and three-dimensional photography (n = 22), we defined the specific distribution patterns of the in-transit metastases on the lower extremity.ResultsUsing a multivariate analysis we identified nodular melanoma, tumor thickness, and ulceration as independent risk factors to develop in-transit metastases ITM (n = 94). In patients with melanoma on the lower leg (n = 31), in-transit metastases preferentially developed along anatomically predefined lymphatic pathways. In contrast when analyzing in-transit metastases of melanoma on the foot (n = 15) no clear pattern could be visualized. In addition, no difference in distance between in-transit metastases and primary melanoma on the foot compared to the lower leg was observed using three-dimensional photography (n = 22).ConclusionA risk-adapted follow-up of melanoma patients to detect in-transit metastases can be applied by knowledge of the specific lymphatic drainage of the lower extremity. Our current analysis suggests a more complex lymphatic drainage of the foot.