bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of inflammatory biomarkers as predictors of treatment efficacy in patients with soft tissue sarcoma treated with trabectedin
Authors: Imai Toru , Kojima Yuki , Shimoi Tatsunori , Aiba Hisaki , Yazaki Shu , Tokura Momoko , Kawachi Asuka , Mizoguchi Chiharu , Okuma Hitomi S. , Arakaki Motoko , Saito Ayumi , Kita Shoske , Yamamoto Kasumi , Maejima Aiko , Nishikawa Tadaaki , Sudo Kazuki , Noguchi Emi , Yoshida Akihiko , Matsui Yoshiyuki , Iwata Shintaro , Kobayashi Eisuke , Kawai Akira , udagawa Ryoko , Fujiwara Yasuhiro , Yonemori Kan 
Published: May 2023

Abstract
Background: Trabectedin is used as a treatment for advanced-stage soft tissue sarcomas (STSs), particularly liposarcoma and leiomyosarcoma. Aside from its direct effect on tumor cells, trabectedin can affect the immune system in the tumor microenvironment. This study aimed to evaluate whether inflammatory biomarkers predict trabectedin efficacy in STSs.
Methods: We retrospectively reviewed the clinical features and outcomes of patients with STS treated with trabectedin at our institution between 2016 and 2020. The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and systemic inflammation response index (SIRI = neutrophil × monocyte/lymphocyte) were calculated based on the blood samples obtained prior to trabectedin treatment initiation. Analyses of the overall survival (OS) and progression-free survival (PFS) were performed according to various factors.
Results: Of the 101 patients identified, 54 had L-sarcoma (leiomyosarcoma: 30; liposarcoma: 24), and 47 had other types of STSs. Elevated SIRI, NLR, PLR, LMR, and C-reactive protein (CRP) were associated with worse PFS (P < 0.001, P = 0.008, P = 0.027, P = 0.013, and P < 0.001, respectively) according to the results of the univariate analysis. Multivariate analysis showed that elevated SIRI, other histology, and CRP were associated with poor PFS (P = 0.007, P = 0.008, and P = 0.029, respectively). In addition, the multivariate analysis of OS showed that SIRI was an independent prognostic factor (hazard ratio: 2.16, P = 0.006).
Conclusion: Pretreatment SIRI can be considered a biomarker for the prognostic prediction of patients with STS treated with trabectedin.
A Hybrid Multifunctional Physicochemical Sensor Suite for Continuous Monitoring of Crop Health
Authors: Hossain Nafize Ishtiaque , Tabassum Shawana 
Published: May 2023

Abstract
This work reports a first-of-its-kind hybrid wearable physicochemical sensor suite that we call PlantFit for simultaneous measurement of two key phytohormones, salicylic acid, and ethylene, along with vapor pressure deficit and radial growth of stem in live plants. The sensors are developed using a low-cost and roll-to-roll screen printing technology. A single integrated flexible patch that contains temperature, humidity, salicylic acid, and ethylene sensors, is installed on the leaves of live plants. The strain sensor with in-built pressure correction capability is wrapped around the plant stem to provide pressure-compensated stem diameter measurements. The sensors provide real-time information on plant health under different amounts of water stress conditions. The sensor suite is installed on bell pepper plants for 40 days and measurements of salicylic acid, ethylene, temperature, humidity, and stem diameter are recorded daily. In addition, sensors are installed on different parts of the same plant to investigate the spatiotemporal dynamics of water transport and phytohormone responses. Subsequent correlation and principal component analyses demonstrate the strong association between hormone levels, vapor pressure deficit, and water transport in the plant. Our findings suggest that the mass deployment of PlantFit in agricultural settings will aid growers in detecting water stress/deficiency early and in implementing early intervention measures to reduce stress-induced yield decline.
The Growth of Online Retailing in India
Authors: Samprathi Srinivas 
Published: May 2023

Abstract
Industrial experts have agreed that India’s small-scale industries are intensely competitive due to globalization, domestic economic liberalization, and digitization. The purpose of this quantitative correlational study was to evaluate the relationship between transaction costs, customer satisfaction, and customer trust in online shopping with the growth of online retailing in India. The theoretical foundation for this research study was the theory of planned behavior, and the unified theory of acceptance and the use of technology. The research questions examined India’s online retailing growth due to transaction costs, customer satisfaction, and customer trust. The study used a quantitative correlational research design. The data collected by the survey research method were analyzed with the software package IBM SPSS. The results indicated that customer satisfaction and transaction cost are significant predictors and can explain 59% (adjusted R2 = .589) of the variance in online retailing growth in India. The previous research had not empirically verified the relationship between transaction costs, customer satisfaction, and customer trust in online shopping with the growth of online retailing in India. The recommendation was to include environmental factors and to increase sample size in future research. Closing the gap may contribute to a positive social change by preparing small business owners to compete against online retail growth by understanding which factors affect the growth of online retail in India. With online shopping support, small business owners can implement measures to retain and attract customers of specific demographic groups.
Comparison on efficiency of pulse electric field, cold plasma and enzymatic pre-treatments for barberry anthocyanins extraction: Modeling and optimization
Authors: Dara Arash , Feizy Javad , Naji-Tabasi Sara , Fooladi Ebrahim , Rafe Ali 
Published: May 2023

AbstractBarberry fruit is a good source of natural antioxidants and various functional compounds such as flavonoids, polyphenols, anthocyanins, vitamins, and pigments.Polyphenols and anthocyanins from barberry extract are directly related to health-promoting activities, and advanced extraction methods could increase the extraction efficiency. This research investigated and compared the conditions optimization for extracting anthocyanins and polyphenols through pulsed electric field, cold plasma, and pectinase pre-treatment. Pulsed electric at 3 levels of electric field intensity (3000, 5000, and 7000 V/cm) and three levels of pulse numbers (50, 75, and 100) were applied. Cold plasma was carried out at 3 levels of voltage (60, 70, and 80 kV) and 3 levels of time (1, 3, and 5 min); also, enzymatic method, which leads to the best results enzyme concentration (0.5, 1, and 1.5%) and temperature (40, 50, and 60 °C), was performed. The optimum conditions for pulse electric field were (7000 V/cm, 100), for cold plasma pre-treatment was (80 kV, 5 min) and for enzymatic pre-treatment was (1.5%, 60 °C). The comparison between different pre-treatments showed that, the enzymatic pre-treatment resulted in the best anthocyanins and polyphenols extraction efficiency was due to enzymes disrupt the complex cell wall structure to release the active constituents more effectively than other pre-treatment methods.
Design and Optimization of Sequence Generator Using N-N Transvidkan Gate
Authors: Ramakrishnan Kannan , Vidhya K. 
Published: May 2023

Abstract
Nowadays, electronic systems are a significant part of human life. The sophistication and complexity of these systems increase with developing technology. These advancements, however, lead to an increase in power consumption, and reduction in area availability, causing issues related to microchip technology. This is where reversible logic helps in saving power and facilitating zero-power computation. It enables the development of various combinational circuits and sequential circuits. The modified gate diffusion input (MGDI) method is characterized as a new approach bearing a circuit design with a low-power digital combination. This technique lowers propagation latency, power consumption, and transistor size of digital circuits, while keeping the logic architecture simple. A comparison of performance between typical CMOS and different pass transistor logic design methodologies is obtainable. Examples of reversible logic gates are DOUBLE FEYNMAN gate, NOT gate, FEYNMAN gate, etc. This paper performs the transistor-level execution of certain primary reversible gates and discusses the results.
Association between osteoporosis and coronary heart disease in the elderly
Authors: Xiong Jing , Qi Mingyu , Shi He , Zou Deli , Liu Quanxiang , Cheng Wei 
Published: May 2023

AbstractBackgroundCoronary heart disease and osteoporosis are common diseases in the elderly, which have high mortality. Objective: To study the relationship between osteoporosis and coronary heart disease in the elderly.Methods345 elderly patients (> 60 years) were randomly selected to investigate the basic information, biochemical indicators, bone mineral density (BMD), and bone turnover markers (BTMs). The relationship between osteoporosis and coronary heart disease in the elderly was studied by recording and statistical analysis.ResultsThere were significant differences in gender, age, body mass index (BMI), hypertension, diabetes, smoking, drinking, and BMD (P < 0.05) in the coronary heart disease group, while no significant difference was observed in heart rate, Ca, P, OC, and CTX (P > 0.05). Osteoporosis was an independent risk factor for coronary heart disease in the elderly, and BMD was negatively correlated with the modified Gensini score and Agatston score.ConclusionOsteoporosis in the elderly is closely related to coronary heart disease and is an independent risk factor of coronary heart disease. The lower the BMD, the higher the risk of coronary heart disease.
Cement pavement void detection algorithm based on GPR signal and continuous wavelet transform method
Authors: qiuqin Yu , youxin Li , tingyi Luo , Zhang Jun , liang Tao , xin Zhu , liufen Luo , xinxin Xu , Yun Zhang 
Published: May 2023

Abstract
The dimension of the void area in pavement is crucial to its structural safety. However, there is no effective method to measure its geometric parameters. To address this issue, a void size extraction algorithm based on the continuous wavelet transform (CWT) method was proposed using ground-penetrating radar (GPR) signal. Firstly, the Finite-Difference Time-Domain (FDTD) method was used to investigate void areas with different shapes, sizes, and depths. Next, the GPR signal was processed using the CWT method, and a 3D image of the CWT result was used to visualize the void area. Based on the differences between the void and normal pavement in the time and frequency domains, the signal with maximum energy at the CWT time-frequency result was extracted and combined to reconstruct the B-scan image, where void areas have energy concentration phenomenon, which represent the location of the void area. And width and depth of void detection algorithm was proposed to recognize the energy concentration area. Finally, the detection algorithm was verified both in numerical model and physical lab model. The results indicated that the CWT time-frequency energy spectrum can be used to enhance the void feature, and the 3D CWT image can clearly visualize the void area with a highlighted energy area. After fully testing and validating in numerical and lab models, our proposed method achieved high accuracy for void width and depth extraction, providing a precise method for estimating void dimension in pavement. This method can guide DOT departments to carry out pre-maintenance, thereby ensuring pavement safety.
Temperature increase alters fatty acid composition and has negative effects on reproductive output of the benthic copepod Microarthridion littorale (Copepoda: Harpacticoida)
Authors: Relva Julieta Vigliano , Colen Carl Van , Barhdadi Wissam , Daly Aisling , De Troch Marleen 
Published: May 2023

Abstract
Copepods are marine invertebrates with a key role at the basis of marine food webs due to their high biomass as well as their elevated fatty acid (FA) content, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), two FA which have a well demonstrated role in growth and reproduction in marine organisms. Temperature is a key driver of organisms fitness as well as ecosystem functioning and sea surface temperature is expected to rise under all CO2 emission scenarios. Thus, understanding how copepods will response to such changes is crucial given their role in marine food webs. While the majority of research has focused on planktonic copepod species, less is known for benthic species, particularly non-model species. In this study we expose Microarthridion littorale, an intertidal benthic copepod to a temperature gradient (12, 15, 18, 21 and 24 °C) including current environmental variability as well as future scenarios. Individuals were retrieved from a mudflat in the Westerschelde estuary (51°21′ 24′′ N, 3° 42′ 51′′E) and cultured at lab conditions. Survival and FA were measured after 18 days exposure. Growth rates and nauplii production were also measured for each temperature treatment. We found decreased survival, EPA and DHA content with increased temperature as well as increased growth rates and detrimental effects for nauplii production. Benthic copepods are prey for many juvenile fish, any changes in their biomass as well as their FA composition in response to temperature changes could therefore amplify to higher trophic levels with important consequences for food web functioning.
Liquid Phase Epitaxy of CuGaO2 on GaN: P-N Heterostructure for Photocatalytic Water Splitting
Authors: Sena Hadi , Kitano Sho , Habazaki Hiroki , Fuji Masayoshi 
Published: May 2023

Abstract
Semiconductor photocatalytic water splitting is a promising method to address the worldwide energy issues. Fast carrier recombination and the limited visible-light absorption are two main challenges to be overcome, and designing p-n heterojunctions is an effective solution. In this study, two direct band gap semiconductors are selected to form a p-n heterojunction. Results show that liquid phase epitaxy of a thick film p-type CuGaO2 on an n-type GaN substrate is effective for the splitting of water into hydrogen and oxygen.
Mapping of quantitative trait loci linked to Phytophthora nicotianae var. parasitica resistance in tomato (Solanum lycopersicum L.)
Authors: Chaudhary Shilpa , Kaur Rajinder , Singh Shiv Pratap , Sharma Monica 
Published: May 2023

Abstract
Buckeye rot is the most devastating disease of tomato. As no work has been done to tag genes responsible for resistance to this disease, present study was planned out to generate segregating population by crossing susceptible parent ‘Solan Lalima’ and resistant parent ‘EC-251649’, followed by phenotypic and genotypic screening of 100 F2 segregants and finally identification of Quantitative Trait Loci (QTL). On phenotyping F2 segregants were scaled in three main categories, five plants as resistant, 43 as susceptible and 52 as highly susceptible. Out of total 153 primers used, 93 primers were found polymorphic with parents which were used for genotyping studies of F2 population. MAPMAKER/EXP version 3.0b resulted in construction of 12 linkage groups with coverage of total genetic map distance of 4660.7 cM. Linkage group 2 was the largest group spanning a distance of 4584.9 cM. QTL Cartographer detected total 22 QTL with placement of 20 QTL on chromosome 2 and single QTL each on chromosome 6 and 7. Identified markers can further be used for marker assisted selection and other molecular studies.
Genome-wide identification reveals that BZR1 family transcription factors involved in hormones and abiotic stresses response of lotus (Nelumbo)
Authors: Zhou Ping , Huiyan Jiang , Jingwen Li , Qijiang Jin , Yanjie Wang , Yingchun Xu 
Published: May 2023

Abstract
Background The brassinazole-resistant (BZR) transcription factors (TFs) are key components of BR signaling, which play an important role in regulating plant growth, development and responding to abiotic stress. However, the functional study of BZR transcription factors in lotus has not been reported.Results A total 10 BZR1 genes (4 NnBZR1 and 6 NlBZR1) were identified from the genomes of two lotus species (Nelumbo nucifera and Nelumbo lutea). The construction of phylogenetic tree showed that the 10 BZR1 genes of lotus were divided into 4 groups, the NnBZR1s and NlBZR1s were unevenly distributed on 3 and 4 chromosomes, respectively. Gene structure analysis showed that motif 1 and motif 9 are highly conserved in lotus BZR1 protein, which might be related to the conserved domain BES_N of BZR1. The analysis of promoter cis-acting elements showed that the promoters of most of the BZR1 genes in lotus contained elements related to light-responsive, ABA-responsive and abiotic stress-responsive, indicating that the BZR1 gene of lotus played an important role in its response to abiotic stress. The expression profiles of different tissues indicated that the NnBZR1 genes were mainly expressed in the carpel, apical bud and seed coat, suggesting that the NnBZR1 genes may play an important role in reproduction and dormancy in lotus. The responses of 6 genes NnBZR1s, Nn1g01524.2 and Nn5g29512.5 to BR, ABA and 4 abiotic stresses (Cold, PEG6000, Cd and NaCl) were analyzed by qRT-PCR. The qRT-PCR results were further verified that the lotus BZR1 genes play an important role in responding to gene signals and resisting abiotic stress.Conclusions This study laid the foundation for further research on the function of lotus BZR1 genes, and provided a theoretical basis for future breeding and horticultural applications.
Changes of roots metabolites and soil microbial community structures in rhizospheres of sugarcanes under different propagation methods
Authors: Lin Xinru , Yang Da , Zhu Yu , Qin Yonglin , Liang Tian , Yang Shangdong , Tan Hongwei 
Published: May 2023

Abstract
Background To provide new insights in selecting proper propagation methods for sugarcane production. soil fertility, root metabolome and soil microbial community structure in rhizospheres of sugarcanes under different propagation methods (tissue culture and stem propagation) were analyzed.Results The results showed that the activities of soil β-Glucosidase and Aminopeptidase, soil microbial biomass nitrogen ( MBN) in rhizospheres of sugarcanes with tissue culture method were all significantly higher than those of stem propagation method. In addition, the soil bacterial and fungal diversities in rhizospheres of sugarcanes were also significantly increased with the tissue culture propagation method. Moreover, in comparison with stem propagation method, higher abundant beneficial microorganisms such as Actinobacteria, Bacteroidota, Myxococcota, Ascomycota, Bradyrhizobium, Sphingomonas, Streptomyces, Exophiala and Aspergillus enriched in rhizospheres of sugarcanes under tissue culture method, regardless of newly planted or ratoon canes. Meanwhile, the compositions and functions of cane root metabolites also could be significantly altered by different propagation methods. Firstly, the biosyntheses of flavonoids and flavonols were significantly up-regulated in cane roots under the tissue culture propagation (TCN) method. Also, the metabolisms of alanine, aspartate and glutamate were significantly up-regulated in cane roots under the tissue culture propagation (TCR) method.Conclusions All above results suggested that soil fertility and health in rhizospheres of sugarcanes could be significantly improved by tissue culture propagation method. It indicates that tissue culture propagation method can be developed as a sustainable method for future sugarcane production.
Development of a Biomarker Panel for Assessing Cardiovascular Risk in Diabetic Patients with Chronic Limb-Threatening Ischemia (CLTI): a Prospective Study
Authors: Nardella Elisabetta , Biscetti Federico , Rando Maria Margherita , Cecchini Andrea Leonardo , Nicolazzi Maria Anna , Rossini Enrica , Angelini Flavia , Iezzi Roberto , Eraso Luis H , Dimuzio Paul J , Pitocco Dario , Massetti Massimo , Gasbarrini Antonio , Flex Andrea 
Published: May 2023

Abstract
Background: Lower-extremity endovascular revascularization (LER) is often required for diabetic patients with chronic limb threatening ischemia (CLTI). During the post-revascularization period patients may unpredictably experience major adverse cardiac events (MACE) and major adverse limb events (MALE). Several families of cytokines are involved in the inflammatory process that underlies the progression of atherosclerosis. According to current evidence, we have identified a panel of possible biomarkers related with the risk of developing MACE and MALE after LER.
The aim was to study the relationship between a panel of biomarkers - Interleukin-1 (IL-1) and 6 (IL-6), C-Reactive Protein (CRP), Tumor Necrosis Factor-α (TNF-α), High-Mobility Group Box-1 (HMGB-1), Osteoprotegerin (OPG), Sortilin and Omentin-1- at baseline, with cardiovascular outcomes (MACE and MALE) after LER in diabetic patients with CLTI.
Methods: In this prospective non-randomized study, 264 diabetic patients with CLTI undergoing endovascular revascularization were enrolled. Serum levels of each biomarker were collected before revascularization and outcomes’ incidence was evaluated after 1, 3, 6 and 12 months.
Results:During the follow-up period, 42 cases of MACE and 81 cases of MALE occurred. There was a linear association for each biomarker at baseline and incident MACE and MALE, except Omentin-1 levels that were inversely related to the presence of MACE or MALE. After adjusting for traditional cardiovascular risk factors, the association between each biomarker baseline level and outcomes remained significant in multivariable analysis. Receiver operating characteristics (ROC) models were constructed using traditional clinical and laboratory risk factors and the inclusion of biomarkers significantly improved the prediction of incident events.
Conclusions: Elevated IL-1, IL-6, CRP, TNF-α, HMGB-1, OPG and Sortilin levels and low Omentin-1 levels at baseline correlate with worse vascular outcomes in diabetic patients with CLTI undergoing LER. Assessment of the inflammatory state with this panel of biomarkers may support physicians to identify a subset of patients more susceptible to the procedure failure and to develop cardiovascular adverse events after LER.