bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous positive airway pressure treatment from the prehospital field in a Japanese regional Doctor Car system
Authors: Takeuchi Ichiro , Imaki Shohei , Furuya Ryosuke , Iwashita Masayuki , Takahashi Kohei , Furuya Akihiro , Yoshida Atsushi , Abe Takeru 
Published: September 2023

AbstractBackgroundContinuous positive airway pressure (CPAP) therapy is an effective treatment for patients with severe heart failure, and certain guidelines recommend its early initiation. However, the current Japanese law strictly prohibits paramedics from administering this treatment. To demonstrate the efficacy and safety of prehospital administration of CPAP therapy, this study was conducted by the Yokohama Medical Control Council (Yokohama MC).MethodsThe Yokohama MC established a protocol for CPAP treatment and dispatched Doctor Cars to attend to patients with severe respiratory failure. The Boussignac CPAP system was installed in all Yokohama Doctor Cars, including Workstation‐type Doctor Cars and Hospital‐type Doctor Cars. Data from this study were collected and recorded in the Yokohama City Doctor Car Registry system from October 2020 to January 2022.ResultsThe Doctor Car was dispatched 661 times, and CPAP therapy was administered to 13 patients in the prehospital field. It is important to note that the number of CPAP cases was lower than anticipated due to the coronavirus disease 2019 (COVID‐19) pandemic, given concerns about aerosol production. When assessing changes over time in oxygen saturation (SpO2), the median (interquartile range), excluding missing values, was 89% (83%–93%) without oxygen, 95% (94%–99.3%) with oxygen, and 100% (97%–100%) with CPAP. The differences between these groups were statistically significant with a p‐value of <0.0001. Respiratory distress was primarily attributed to heart failure in 10 patients (91%) and pneumothorax in 1 patient (9%). Notably, none of the patients’ conditions worsened after the use of CPAP.ConclusionWe have detailed the administration of CPAP therapy in the prehospital field within a local city in Japan. To the best of our knowledge, this represents the inaugural report of a prospective observational study on the prehospital administration of CPAP therapy originating from Japan.
All‐Dielectric Multichannel Terahertz Metasurface Empowering Independent Wavefront Manipulation
Authors: Yue Zhen , Li Jitao , Li Jie , Zheng Chenglong , Lu Binbin , Liu Jingyu , Yang Fan , Li Hui , Zhang Yan , Zhang Yating , Zang Xiaofei , Yao Jianquan 
Published: September 2023

AbstractMetasurfaces have demonstrated unprecedented capabilities in modulating the polarization and phase of electromagnetic waves and formed an emerging field of research, driving the exploitation of versatile compact devices. In this work, one transmission‐mode, multichannel all‐silicon metasurface platform that can implement functionalities separately in two orthogonally polarized output fields under linearly polarized incidences is proposed, which can effectively promote the design flexibility. Specifically, a single metasurface can realize multiple independent target phase distributions carrying specific phase relationships, thus enabling different information processing in different linear polarization states. For proof‐of‐principle experimental exhibitions, a monolayer metasurface composed of silicon pillars is designed, fabricated, and characterized to demonstrate the ability of multi‐dimensional light field control, such as polarization‐switchable focusing beam. Moreover, the other designed metasurface can generate polarization‐switchable Bessel vortex beams under linearly polarized incidences, which also verifies the flexibility and practicality of such platform. This metasurface platform may lead to new optical components, involving multichannel singular beam generators, information encoders, and holographic encryption devices.
Strukturen, Bindungsanalyse und Reaktivität eines dikationischen Digallens und eines Diindens, die trans‐gefaltete Ditetrylene nachahmen
Authors: Barthélemy Antoine , Scherer Harald , Daub Michael , Bugnet Alexis , Krossing Ingo 
Published: September 2023

AbstractDie Reaktion von Bisdicyclohexylphosphinoethan (dcpe) und den subvalenten MI‐Quellen [MI(PhF)2][pf] (M=Ga+, In+; [pf] −=[Al(ORF)4]−; RF=C(CF3)3) ergab die Salze [{M(dcpe)}2][pf]2, die die ersten bisher dokumentierten dikationischen, trans‐gefalteten Digallen‐ und Diindenstrukturen enthalten. Die nicht‐klassischen MI⇆MI‐Doppelbindungen sind überraschend kurz und zeigen eine ditetrylenartige Struktur. Die Bindungssituation wurde durch quantenchemische Berechnungen, QTAIM‐ (Quantum Theory of Atoms in Molecules) und EDA‐NOCV‐Analysen (Energy Decomposition Analysis with the combination of Natural Orbitals for Chemical Valence) umfassend analysiert und mit derjenigen in den isoelektronischen und isostrukturellen, aber neutralen Digermenen und Distannenen verglichen. Das gelöste [{Ga(dcpe)}2]2+([pf]−)2 reagiert unter milden Bedingungen bei Raumtemperatur mit 1‐Hexen, Cyclooctin, Diphenyldisulfid und Diphenylphosphan. Diese Reaktivität wird analysiert und rationalisiert.
Towards improving user awareness of search engine biases: A participatory design approach
Authors: Paramita Monica Lestari , Kasinidou Maria , Kleanthous Styliani , Rosso Paolo , Kuflik Tsvi , Hopfgartner Frank 
Published: September 2023

AbstractBias in news search engines has been shown to influence users' perceptions of a news topic and contribute to the polarisation of society. As a result, there is a need for news search engines that increase user awareness of biases in the search results. While technical approaches have been developed to mitigate biases in search, very few studies have investigated user preferences in interface designs for potentially raising their awareness of biases in news search engines. In this study, we utilized a participatory design methodology to develop eight prototypes with different features that could potentially be used to raise user awareness of biases in news search engines. We conducted three user studies, involving 132 participants with Computer Science backgrounds, to evaluate these prototypes. Our findings indicate the importance of news search engines that (a) inform users of possible biases in the results (bias visualization approach) and (b) allow users to access alternative search results (results‐reranking approach). Our study provides further insights into the strengths and possible risks of each approach, which are important for future research on designing interfaces for raising user awareness of biases in news search engines.
The effect of the 1‐in‐X numerical format on choices
Authors: Pighin Stefania , Bogani Alessandro , Davalos Gloria Berenisse Castro , Savadori Lucia 
Published: September 2023

AbstractThe 1‐in‐X numerical format (e.g., 1 in 200) has been found to increase subjective probability evaluations and behavioral intentions in hypothetical scenarios compared with the N‐in‐NX format (e.g., 5 in 1000). However, it remains unclear whether this format can also bias choices between truly incentivized options. In four online studies (N = 1039), participants were presented with a small endowment (i.e., 1£) and an actual choice between two options: a sure loss of a part of such endowment and a lottery with the chance to lose the entire endowment, presented using either the 1‐in‐X or the N‐in‐NX format. In Studies 1–3, where the two options were equivalent in expected monetary value (EV) and the lottery was described with varying degrees of concreteness, participants preferred the lottery option to a lesser extent when the chance of losing the endowment was presented using the 1‐in‐X format compared with the N‐in‐NX format. The same effect was replicated in Study 4a when the lottery option had a higher EV than the sure loss, showing that the 1‐in‐X effect can also lead individuals to deviate from maximizing EV. However, the effect vanished in Study 4b when the difference in EV between the two options increased. Implications for risk communication and a possible interpretation of the results are discussed accordingly.
Sustainable entrepreneurship practices of Indian SMEs: A strategic approach using fuzzy Delphi and best worst method
Authors: Ghag Nikhil , Sonar Harshad 
Published: September 2023

AbstractSmall and medium‐sized enterprises (SMEs) make up a sizable portion of the business sector in most countries. These businesses are also becoming more concerned about sustainability and how to strategically incorporate it into their operations. However, SMEs have shied away from sustainability investments due to a lack of a comprehensive viewpoint on the matter, an overemphasis on an economic perspective, and the resulting devaluation of environmental and social viewpoints. Though the importance of social and environmental practices for assessing sustainable entrepreneurship (SE) has increased, very little research has been done on SE, particularly those linked to the competitiveness of SMEs. The novelty lies in the identification of social and environmental practices for SE and analyzing it using the best worst method. The two main objectives are to calculate the relative weights of these practices and to identify the most crucial elements for judging SMEs' propensity for SE. The findings of this study have significant consequences not only for the businesses themselves but also for decision‐makers in charge of putting policies in place that make it easier to take actions that are consistent with SE.
Comprehensive treatment of von Hippel‐Lindau disease: A case report
Authors: Li Xuesong , Mo Zheng , Yu Zhuo 
Published: September 2023

Abstractvon Hippel‐Lindau (VHL) disease is a rare autosomal dominant multiorgan disease characterized by several benign and malignant tumors rich in vascular, as well as cysts in other organs. A great clinical treatment strategy is significantly warranted for good prognosis of patients with VHL disease. Herein, we reported a case of a 45‐year‐old woman diagnosed with VHL disease with spinal hemangioblastoma (HB) and clear cell renal cell carcinoma (ccRCC). Four years after the resection of the right kidney, a recurrent RCC in the right kidney and a malignant lesion in the left kidney were observed. This patient was started on sorafenib (800 mg, daily) and tislelizumab (200 mg per 3 weeks). After 6 months of treatment, the size of renal cell carcinoma was dramatically reduced and renal function improved. More importantly, she achieved partial response during the whole treatment. Microscopically, intramedullary masses resection was done and the HB in T4‐5 thoracic spinal was removed. Neurologic symptoms such as numbness and pain were remarkably alleviated. Additionally, tislelizumab‐induced elevation in liver transaminase levels and hypothyroidism were revered by hepatoprotector and levothyroxine, respectively. In short, comprehensive treatment strategies may benefit patients with VHL disease, especially with HB and ccRCC.
Distinctive Arbutin‐Containing Markers: Chemotaxonomic Significance and Insights into the Evolution of Proteaceae Phytochemistry
Authors: Zarfos Samuel D. , Deans Bianca J. , Ho Curtis C. , Jordan Gregory J. , Smith Jason A. , Bissember Alex C. 
Published: September 2023

AbstractNatural products isolation studies of eight endemic Tasmanian Proteaceae species – Agastachys odorata, Persoonia juniperina, Hakea megadenia, Hakea epiglottis, Orites diversifolius, Orites acicularis, Orites revolutus, and Telopea truncata – and three endemic Australian Proteaceae species Banksia serrata, Banksia praemorsa, and Banksia marginata were undertaken. Two previously unreported glycoside‐derived natural products were identified, in addition to four other tremendously rare arbutin esters. The results of this study provide further evidence consistent with the proposal that these distinctive arbutin esters represent markers that can provide valuable insights into the chemical evolution of plant species within the family Proteaceae.
The Conversion of UDP‐Glc to UDP‐Man: In Silico and Biochemical Exploration To Improve the Catalytic Efficiency of CDP‐Tyvelose C2‐Epimerases
Authors: Vogel Ulrike , Da Costa Matthieu , Alvarez Quispe Carlos , Stragier Robin , Joosten Henk‐Jan , Beerens Koen , Desmet Tom 
Published: September 2023

AbstractA promiscuous CDP‐tyvelose 2‐epimerase (TyvE) from Thermodesulfatator atlanticus (TaTyvE) belonging to the nucleotide sugar active short‐chain dehydrogenase/reductase superfamily (NS‐SDRs) was recently discovered. TaTyvE performs the slow conversion of NDP‐glucose (NDP‐Glc) to NDP‐mannose (NDP‐Man). Here, we present the sequence fingerprints that are indicative of the conversion of UDP‐Glc to UDP‐Man in TyvE‐like enzymes based on the heptagonal box motifs. Our data‐mining approach led to the identification of 11 additional TyvE‐like enzymes for the conversion of UDP‐Glc to UDP‐Man. We characterized the top two wild‐type candidates, which show a 15‐ and 20‐fold improved catalytic efficiency, respectively, on UDP‐Glc compared to TaTyvE. In addition, we present a quadruple variant of one of the identified enzymes with a 70‐fold improved catalytic efficiency on UDP‐Glc compared to TaTyvE. These findings could help the design of new nucleotide production pathways starting from a cheap sugar substrate like glucose or sucrose.
Giant cell lichenoid dermatitis within healed varicella zoster site
Authors: Alghamdi Yara , Almahdi Bashaer , Alsifri Sahar , Huwait Hassan , Jfri Abdulhadi 
Published: September 2023

Key Clinical MessageThere are dermatoses that arise within healed zosteriform sites, such as granulomas annulare, acneiform eruptions, psoriasis, lichen planus, and giant cell lichenoid dermatitis “GCLD.” Nonetheless, graft‐versus‐host disease should be considered and ruled out, especially in patients post‐bone marrow transplant. Herein, we report a case of GCLD manifesting within healed zosteriform sites.
Recurrent pancreatitis secondary to hypertriglyceridemia: A case report and case review
Authors: Nazeef Mohamed , Devkota Sagar , Mainali Sumnima , Thapa Yubaraj , Upadhyay Sristi , Yadav Priyanka , Shrestha Jeena 
Published: September 2023

Key Clinical MessageManaging acute pancreatitis secondary to hypertriglyceridemia in pregnancy is challenging. The use of intravenous insulin along with lipid lowering drugs can be an option in settings where plasmapharesis and gene therapy are unavailable.AbstractAcute pancreatitis secondary to hypertriglyceridemia is rare but various studies have highlighted it as the third most common cause following gallstones and alcohol consumption. Managing acute pancreatitis is always challenging; even more challenging during pregnancy. We present a case of a 31‐year– old female with a history of recurrent pancreatitis secondary to hypertriglyceridemia with a current episode of acute pancreatitis at 21 weeks of gestation.
A rare case of intra‐parenchymal meningioma in a female patient who presented with seizures: A case report
Authors: Duvuru Shyam , Sanker Vivek , Jain Samiksha , Kumar B. S. Sunil , Manoj Kumar M. , Gupta Umang 
Published: September 2023

Key Clinical MessageMeningiomas are slow‐growing tumors that develop from the arachnoid cap cells' meningothelial cells. Males are more likely to develop intra‐parenchymal meningiomas, which also manifest earlier than ordinary meningiomas and are uncommon.AbstractMeningiomas are slow‐growing neoplasms which arise from the meningothelial cells of the arachnoid cap cells. Unlike other meningiomas, intra‐parenchymal meningiomas do not originate from dura. Intra‐parenchymal meningiomas are more common in males and develop earlier than regular meningiomas. Because of the rare occurrence the intra‐parenchymal meningiomas, they are commonly misdiagnosed.
Two cases of acute‐onset cystoid macular edema and serous retinal detachment associated with combined use of encorafenib and binimetinib for advanced melanoma: A possible confounding risk for drug intolerance
Authors: Hasegawa Takumi , Iino Shiro , Fujisaki Misako , Okamura Sayuri , Baba Natsuki , Tanaka Nami , Takeuchi Yuko , Oyama Noritaka , Hasegawa Minoru 
Published: September 2023

AbstractWhile combined use of BRAF/MEK inhibitors has elicited dramatic clinical efficacy in incurable melanoma, drug‐associated retinopathy has become an emerging adverse event. We present two Japanese men with advanced melanoma who developed visual impairment due to serous retinal detachments (SRDs) with cystoid macular edema (CME) immediately after initial administration of encorafenib/binimetinib, a BRAF and MEK inhibitor. One case had drug‐intolerable retinopathy on repeat dosing. Both cases were switched to another BRAF/MEK inhibitors, dabrafenib/trametinib, with no recurrence of SRDs. Co‐existing CME may be a confounding risk for the early development of SRDs with encorafenib/binimetinib therapy, providing attention during drug administration.
Heterogeneous catalytic ozonation of organic wastewater by using bimetallic catalysts supported on honeycomb‐structured activated carbon
Authors: Liu Ping , Wang Lechao , Du Le , Zhu Jiqin 
Published: September 2023

AbstractHoneycomb‐structured activated carbon (HAC) is one of the most studied chemicals with large specific surface area, high porosity, unique adsorption properties, and other characteristics, which has been widely used in the fields of exhaust gas adsorption, wastewater adsorption, and catalyst support. However, the study and application of HAC in the field of wastewater treatment is not extensive. Herein, a novel HAC‐based bimetallic catalyst was prepared by incipient wetness co‐impregnation, which exhibited high catalytic activity in heterogeneous catalytic ozonation of methylene blue (MB) organic wastewater. A high MB removal of 95.43% and a chemical oxygen demand (COD) removal of 85.19% were achieved by using Cu‐La/HAC under optimized conditions. The inductively coupled plasma‐mass spectrometry (ICP‐MS) results showed that the metal dissolution concentration of Cu‐La/HAC was the lowest. Moreover, X‐ray photoelectron spectroscopy (XPS) characterization of copper‐containing catalysts indicated that the strong interaction between copper and lanthanum resulted in the low metal dissolution concentration.
Could it be hereditary angioedema?—Perspectives from different medical specialties
Authors: Magerl Markus , Sala‐Cunill Anna , Weber‐Chrysochoou Christina , Trainotti Susanne , Mormile Ilaria , Spadaro Giuseppe 
Published: September 2023

AbstractHereditary angioedema (HAE) is a rare autosomal dominant disease, with patients often suffering with associated symptoms for many years before receiving a correct diagnosis. The symptoms greatly impact a patient's quality of life (QoL) and include excruciating abdominal pain and angioedema of the skin and submucosa. Angioedema of the larynx represents a significant mortality risk in undiagnosed patients, and a large proportion of patients with HAE receive incorrect diagnoses and undergo unnecessary surgery. HAE‐specific treatments can control and prevent acute life‐threatening episodes, in addition to improving QoL, emphasizing the value of early diagnosis for patients. Diagnostic delay may be due to a lack of HAE awareness by healthcare professionals and the similarity of HAE symptoms with those of more common conditions, complicating differential diagnosis. The multifaceted nature of the condition may result in visits to one of many different medical settings, for example: the Emergency Room, pediatrics, general practice, otolaryngology, gastroenterology, and dermatology. Therefore, it is crucial that physicians in multiple healthcare specialties are aware of the disease to ensure that patients with HAE receive a timely diagnosis. Using patient cases from various medical specialties, this review highlights the necessity for cross‐specialty awareness of HAE and outlines the essential information for the various healthcare professionals that may encounter a patient with HAE symptoms, in order to effectively treat and/or diagnose HAE.
Fluorescent In Situ Hybridization for miRNA Combined with Staining of Proteins
Authors: Boen Jente R. A. , Pintelon Isabel , Gevaert Andreas B. , Segers Vincent F. M. , van Craenenbroeck Emeline M. 
Published: September 2023

AbstractThe last decades have illustrated the importance of microRNAs (miRNAs) in various biological and pathological processes. The combined visualization of miRNAs using fluorescent in situ hybridization (FISH) and proteins using immunofluorescence (IF) can reveal their spatiotemporal distribution in relation to the cell and tissue morphology and can provide interesting insights into miRNA‐protein interactions. However, standardized protocols for co‐localization of miRNAs and proteins are currently lacking, and substantial technical obstacles still need to be addressed. In particular, the incompatibility of protein IF protocols with steps required for miRNA FISH, such as proteolytic pretreatments and ethylcarbodiimide post‐fixation, as well as hurdles related to low signal intensity of low‐copy miRNAs, remains challenging. Our technique may considerably enhance miRNA‐based research, as current detection techniques lack the ability to elucidate cellular and subcellular localization. Here, we describe an optimized 2‐day protocol for combined detection of low‐abundant miRNAs and proteins in cryosections of cardiac tissue, without the need for protease‐dependent pretreatment or post‐fixation treatment. We successfully demonstrate endothelial‐specific localization of low‐abundant miR‐181c‐5p in cardiac tissue. © 2023 Wiley Periodicals LLC.Basic Protocol: Fluorescent in situ hybridization for miRNA combined with staining of proteins
Assessing the agronomic potential of sorghum B‐lines using genomic prediction
Authors: Kent Mitchell A. , Fonseca Jales M. O. , Klein Patricia E. , Klein Robert R. , Hayes Chad M. , Rooney William L. 
Published: September 2023

AbstractIn hybrid sorghum breeding, basic agronomic traits, such as days to flowering and plant height, of sorghum seed parents must be within a specific range for hybrid seed production. Because many sorghum programs select new B‐lines outside of commercial seed production environments, the purpose of this study was to determine if genomic prediction is effective to evaluate new lines for their agronomic potential for seed production. Two B‐line RIL populations were evaluated across several environments for days to mid‐anthesis (DY), plant height (PH), panicle length (PL), and seed yield (SY). Across environments and populations, average prediction accuracies were between 0.47 and 0.61 for DY, 0.24 and 0.60 for PH, 0.16 and 0.37 for SY, and 0.37 and 0.57 for PL. The effect of training set size was assessed by subsampling various amounts of data into the training set, ranging from 5% to 65%. Prediction accuracies generally improved as the proportion of the total data in the training set increased for both inter‐ and intrapopulation predictions, but a relatively small portion (15%) of the total data still produced modest prediction accuracies. The effect of the marker density on genomic prediction accuracies was assessed by subsampling various numbers of single nucleotide polymorphisms. It was observed that as few as 500 markers were able to produce prediction accuracies similar to when all markers were used. The results of this study indicated that genomic prediction can be a useful and cost‐effective tool that sorghum breeding programs should incorporate into their pipeline.