bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nilai Nutrisi dan Rendemen Ekstrak Metanol Pelet Katuk Depolarisasi sebagai Parameter Standar Mutu Produksi
Authors: Suprayogi Agik , Satrija Fadjar , Muladno Muladno , Tarigan Ronald , Atabany Afton , Hanif Novriyandi , Sugiono Welly , Yuliantoni Yuliantoni 
Published: September 2023

Standardization of the quality of the depolarized katuk pellet production process as a feed additive is very important to maintain product quality. The production process requires dry katuk leaves (DKK) as raw materials which are then processed into depolarized katuk leaves (DKD), and continues in the pelleting process to become depolarized katuk pellets (PKD). Quality standard can be done by measuring the parameters of nutritional value and also the yield of methanol extract. Nutritional values were obtained from the results of proximate analysis, namely the percentage of dry matter, ash content, crude protein, crude fiber, crude fat, beta-N, calcium, phosphorus, and gross energy (Cal/g). Mean while, the yield of methanol extract was obtained by maceration using methanol solvent. This study aims to evaluate the nutritional value and yield of crude methanol extract of katuk leaves (DKK, DKD, PKD) which can be used as a quality assurance standard for the depolarized katuk pellet production process. In general, the nutritional value of DKD and PKD had the same value as that of DKK, except for calcium which was quite high (P<0.05) in DKD and PKD, and the percentage of crude fiber was lower (P<0.05) in PKD compared to DKK and DKD. The percentage of crude fat in pellets (PKD) was higher (P<0.05) when compared to DKK and DKD. The yield of methanol extract was very high (P<0.05) in DKK, compared to DKD and PKD. The nutritional parameters and the yield of the katuk leaf extract can be used as quality assurance standards for the depolarized katuk pellet production process.

Keywords: depolarization, katuk, methanol, nutrition, pellet
Optimasi Penggunaan Input Produksi pada Usahatani Kentang di Dataran Tinggi Dieng, Jawa Tengah
Authors: Sahara Dewi , Munir Eti Wulanjari  , Triastono Joko 
Published: September 2023

Potato is one of the horticultural crops with high economic value and potential as an export commodity. The productivity of potatoes in Central Java tends to decrease, and it is suspected that the use of production inputs is not optimal. This study aims to evaluate the performance of the use of production inputs, the factors that influence potato production, and the optimization of the use of production inputs in potato farming in the Dieng Plateau. The research was conducted from October to December 2021 in Sumberejo Village, Batur Subdistrict, Banjarnegara District, which has an altitude of + 1700 meters above sea level. This research used a survey method on 30 potato farmers. The data obtained were analyzed descriptively, and analyzed the factors that influence production using multiple linear regression, followed by an optimization test on the use of production inputs. The results showed that the use of production inputs among farmers still varied and had not followed the results of soil analysis. Seed, manure, and labor are production inputs that have a significant positive effect on potato production. To get maximum production, farmers need to add seeds, NPK fertilizer, and manure according to recommendations, while the use of labor needs to be reduced to achieve optimal yields.

Keywords: highlands, inputs, increased production, potato, production
Potensi dan Keragaman Bakteri Endofit sebagai Agens Pemacu Pertumbuhan dan Biokontrol Anggrek
Authors: Amba Linggi Mery Irianti , Joko Tri , Widada Jaka 
Published: September 2023

Soft rot disease in orchid plants is a factor in decreasing orchid production. One way of biological control that has the potential to spur growth is to utilize endophytic bacteria. This study aims to describe the diversity of orchid endophytic bacteria that have the potential as growth promoters and biocontrol agents. Observation parameters include indole acetic acid (IAA) production, inorganic phosphate dissolution, ammonia production of orchid endophytic bacteria, and antagonism of endophytic bacteria to pathogenic bacteria that cause soft rot in vitro. The diversity of orchid endophytic bacteria was analyzed using rep-PCR with BOX-A1R primer. The results showed that 10 isolates of orchid endophytic bacteria were able to produce IAA with a concentration of 79–321 μg/mL, able to dissolve phosphate, and produce ammonia. In antagonism testing against soft rot-causing bacteria, all isolates were able to form an inhibitory zone with a diameter of 3–7.2 cm. Furthermore, diversity analysis using rep-PCR showed that isolates of endophytic bacteria DnPh5, BgCt2, BgVt10, DnLp7, DnBl1, and DnAr4 had a uniform DNA band pattern so that they were grouped together. Meanwhile, isolates of TbPh7, IbtPhm1, DnDr2, and AkOc1 showed different DNA band patterns, indicating that the four isolates were different species or subspecies of bacteria. In dendrogram analysis, DnPh5, BgCt2, BgVt10, DnLp7, DnBl1, and DnAr4 isolates have a similarity of 100%. The similarity of isolates IbtPhm1, DnDr2, and AkOc1 was 90%, 79%, and 68%, respectively, against the other six isolates. TbPh7 isolate is an isolate with a low level of similarity to other isolates, which is about 51%.

Keywords: orchid, endophytic bacteria, growth promoter, biocontrol agent, rep-PCR
The THE IMPLEMENTATION OF THE MERDEKA BELAJAR KAMPUS MERDEKA (MBKM) INTERNSHIP PROGRAM IN SOCIOLOGY STUDY PROGRAM, FACULTY OF SOCIAL SCIENCES, STATE UNIVERSITY OF JAKARTA
Authors: Kurniawati Atik , Fitri Meila Riskia , S. K Marista Christina , Saputra Dicky , Firdaus Revania 
Published: September 2023

This study aims to evaluate the implementation of the independent internship program organized by the Ministry of Education, Culture, Research and Technology within the Sociology Study Program, Faculty of Social Sciences, State University of Jakarta using the CIPP evaluation model. The CIPP evaluation model focuses on 4 aspects, namely Context, Input, Process, Product. The type of approach used is a descriptive qualitative approach with data collection techniques through observation, interviews, and literature studies. The results of this study show that based on: (1) Context evaluation is still not optimal, because the involvement of Sociology students only ranges from 15% of batches 1-4 and in batch 4, especially the class of 2020, there are only 4 students who pass the Independent Internship program. Then the vision, mission, and objectives of the Sociology study program are considered to be in accordance with the objectives of the implementation of the Independent Internship program. (2) Input evaluation has been going well, due to the availability of human resources, facilities, and budget funds that are well met. Preparation for the implementation of the Independent Internship has also been well prepared by the Sociology study program and the company, and has had good quality human resources and are competent in their fields. (3) The evaluation process has run well, because it is supported by the study program and participants also have a high level of satisfaction with the Independent Internship program, both from experience, mentors, nor work. Then the effectiveness of excellent mentor assistance makes participants have no significant obstacles in the registration process until the internship program ends. (4) Product evaluation has also been carried out well, because this Independent Internship program can significantly improve the abilities and skills of participants. In addition, participants gain direct work experience and are actively involved in the company, so that participants get professional relationships and clear career paths.
Conceptual Analysis of Self-reliance in Older Adults in South Korea
Authors: Jang Taejeong , Seo Kawoun , Yeom Eun-Yi 
Published: September 2023

Abstract

Background: With population aging becoming a global phenomenon, the burden of supporting older adults is increasing. We aimed to present the dimensions and attributes related to the independence of older adults in Korea, in order to aid with development of measurement tools and future interventional programs.
Methods: Ten adults who were aged ≥65 years, lived in D city, and could move and communicate independently, were enrolled in this study. The three-stage hybrid model proposed by Schwartz-Barcott and Kim was used for our analysis. The independence levels of older adults, derived from the theoretical stage, were assessed in terms of physical, mental, and environmental dimensions.
Results: The independence levels of the participants correlated with tendencies to perform daily life-independent physical activities and self-care, control their lives based on freedom, and actively maintain self-identity. Smoothly interacting with family, neighbors, and support resources while maintaining economic stability and spatial separation represented another critical aspect.
Conclusion: The results of this study suggest the need for an interventional approach for older adults at home to establish self-reliance and improve their quality of life in their environments. Moreover, further research is needed to develop a tool to measure the independence of older adults at home, in addition to the development of nursing intervention strategies for successful aging.
Research on the Time-Varying Mesh Stiffness and Dynamic Characteristics of Steel-POM Gear Pair with Off-Line Meshing
Authors: Xiong Yangshou , Yu Dongyang , Huang Kang , Zhang Jun , Zhang Haibin 
Published: September 2023

Abstract

Plastic gears have been widely used in fields such as instruments, meters, and automotive electronics In particular, metal-plastic gear pairs are commonly used in the low-speed stages of multi-stage gear transmissions to enhance load capacity and achieve lightweight design. However, due to the small elastic modulus and significant temperature sensitivity of plastic gears, off-line meshing phenomenon occurs in metal-plastic gear pairs during operation, which affects the overall system stiffness and dynamic behavior. Therefore, this study focuses on 45# steel-POM gear pair and considers the influence of temperature on the elastic modulus of gears, as well as the impact of off-line meshing on the time-varying stiffness of the gear pair. A lumped parameter method is used to establish a single-degree-of-freedom model of the gear transmission system, and the effect of load on the system's dynamic behavior is investigated. Experimental validation shows that the stiffness varies linearly with the load, and the dynamic performance of the system deteriorates with increasing load. Under the same load, the system with consideration of off-line meshing exhibits better transmission accuracy compared to the one without consideration. This study provides a theoretical basis for the design and transmission of plastic gears in the future.
NLRP3 inhibition attenuates the allergic rhinitis symptoms in an mice model
Authors: Lee Minhyung , Ko Young-Kyung , Gil Chan Hee , Eun Kyoung Mi , Zhang Yu-Lian , Cho Sung-Woo , Kim Dae Woo , Kim Hyun Jik , Rhee Chae-Seo 
Published: September 2023

Abstract
This study aimed to identify the mechanism underlying the activation of Nod-like receptor family, pyrin domain‐containing 3 (NLRP3) inflammasome signaling pathway in an ovalbumin (OVA)-induced allergic rhinitis (AR) mice model and to validate the effect of a specific inhibitor of the NLRP3, MCC950. Mice were divided into three groups and each group consisted of ten mice (saline group, the negative control group; OVA group, the OVA-induced AR model group; and OVA + MCC group, treated with 10 mg/kg MCC950). MCC950 was administered intraperitoneally every second day. Multiple parameters of AR, including NLRP3, caspase-1, interleukin (IL)-1β, and IL-18 were evaluated by using ELISA, RT-qPCR, histopathology, and immunohistochemistry. The mRNA and protein levels of NLRP3, caspase-1, IL-1β and IL-18 were upregulated in the OVA group compared with those of the saline group. MCC950 significantly inhibited the mRNA and protein levels of NLRP3, caspase-1, IL-1β and IL-18 in nasal tissue. Further, AR symptoms and eosinophil count were normalized after MCC950 treatment. However, OVA-specific IgE was not restored in the OVA + MCC group. In conclusion, NLRP3 inflammasome signaling pathway may be an alternative pathway to induce AR symptoms in OVA-induced AR model. MCC950 is a specific inhibitor of NLRP3 cascade, which attenuates AR symptoms regardless of IgE.
Mechanisms of reversal of temozolomide resistance in glioblastoma through downregulation of BCL3 by the Tumor Electric Field Therapy
Authors: Jia Mu-yuan , Liu Yu-yang , Li Ze , Luo Cheng-Ke , Xu Sheng-chao , Gong Huan-Huan , Wu Jianhui , Zhou Dan , Chen Di-kang , WU An-Hua , Liu Zhi-Xiong , Cheng Wen , Wu Hao , Hu Wen-Tao , Chen Jun-Yi , Lan Jin-Xin , Liu Hong-Yu , Sun Dan-Yang , Chen Ling , Liu Jia-Lin 
Published: September 2023

Abstract
To explore the mechanisms behind tumor electric field treatment (TEFT) in reversing temozolomide (TMZ) resistance in glioblastoma (GBM). Transcriptome data of TMZ- resistant GBM cells treated with TEFT were obtained using a novel electric field cell culture device (CL-301A). Key biological processes and genes were identified through differential gene analysis and enrichment analysis. The association between key genes and patient prognosis was examined using a GBM open-source database. The results were validated in two GBM-resistant cell lines(U251R,T98GR)and primary cell lines (GPDC1,GPDC8). The results suggest that TEFT increased the sensitivity of U251R and T98GR to TMZ. Bioinformatics analysis showed the importance of the extracellular matrix structure and identified BCL3 as a key gene. Survival analysis indicated that GBM patients with high BCL3 expression had a poor prognosis. BCL3 was upregulated in U251R and T98GR, increased resistance to TMZ, while BCL3 knockdown resulted in increased sensitivity to TMZ. Western blot assays showed that downregulation of BCL3 decreased AKT phosphorylation and correlated with reduced resistance to TMZ. It was finally concluded that TEFT reversed the drug resistance of GBM to TMZ by reducing AKT phosphorylation and BCL3 expression, enhancing the proapoptotic effect of TMZ on GBM cells. Keywords: tumor electric field therapy; BCL3; drug resistance; glioblastoma; temozolomide.
Role of lung ornithine aminotransferase in Idiopathic Pulmonary Fibrosis: regulation of mitochondrial ROS generation and TGF-β1 activity
Authors: Park Sung Woo , Lee Jong-Uk , Kisung Song , Hong Jisu , Shin Hyesun , Park Eunji , Baek Junyeong , Park Shinhee , Baek Ae Rin , Lee Junehyuk , Jang An-Soo , Kim Do Jin , Chin Su Sie , Jeong Sung Hwan 
Published: September 2023

Abstract

Idiopathic pulmonary fibrosis (IPF) exhibits aberrant lung remodeling that is characterized by excessive accumulation of extracellular matrix (ECM) proteins. In a previous study, we found that levels of ornithine aminotransferase (OAT), a principal enzyme of the proline metabolic pathway, were elevated in the lungs of patients with IPF. However, the precise role played by OAT in IPF pathogenesis is not yet clear. The mechanism by which OAT affected fibrogenesis was assessedin vitrousing lung fibroblasts overexpressing and knockdown of OAT. The therapeutic effects of OAT inhibition were assessed in the lungs of mice treated with bleomycin. OAT expression was increased in fibrotic areas, principally interstitial fibroblasts, of the IPF lung. OAT levels in the bronchoalveolar lavage fluid of IPF patients were inversely correlated with lung function. The survival rate was significantly lower in the group with an OAT level > 75.659 ng/mL than in the group with an OAT level ≤ 75.659 ng/mL (HR, 29.53;p = 0.0008). OAT overexpression and knockdown respectively increased and decreased ECM component production by lung fibroblasts. OAT knockdown also inhibited transforming growth factor-β1 (TGF)-β1 activity and TGF-β1 pathway signaling. OAT overexpression increased the generation of mitochondrial reactive oxygen species (ROS) by activating proline dehydrogenase. The OAT inhibitor L-canaline significantly attenuated bleomycin-induced lung injury and fibrosis. In conclusion, Increased OAT levels in the lung in IPF contributes to fibrotic progression via excessive mitochondrial ROS production that upregulates TGF-β1 signaling. OAT may be a useful therapeutic target in patients with fibrotic lung disease including IPF.
Ginkgo biloba repair spinal cord ischemia reperfusion injury in rats by regulating Ferroptosis signaling pathway
Authors: Zhang Fengyi , Zhang Ding , Guan Xiaoqing , Zong Yuan , Wang Hang , Guo Li , Shen Zhubing , Yin Fei 
Published: September 2023

Abstract
Ferroptosis is a hot topic in recent years. As a new type of cell death, its main signs are iron overload and lipid peroxidation.Spinal cord ischemia reperfusion injury (SCIRI) is often accompanied by reactive oxygen-induced oxidative stress, and the spinal cord is rich in polyunsaturated fatty acids, so it is very easy to undergo lipid peroxidation under the attack of oxygen free radicals after ischemia reperfusion injury, and eventually lead to degeneration and necrosis of nerve cells.Therefore, inhibition of reactive oxygen species accumulation is essential to reduce nerve cell death after SCIRI.Our previous studies have shown that Ginkgo biloba (GB) can remove oxygen free radicals produced during ischemia reperfusion in the spinal cord of rats, but the specific mechanism of action is unclear.In this study, we first obtained the genes of the SCIRI group and model group through bioinformatics analysis, and then intersects the genes related to ferroptosis to verify the most specific genes.After subsequent experiments, we found that Ginkgo biloba extract (GBE) can significantly increase glutathione peroxidase 4 (GPX4),solute carrier family7 member11 (SLC7A11) and augmenter of liver regeneration (ALR), decrease the expression of 4-hydroxy-2-nonenal (4-HNE) and transferrin receptor 1 (TfR1), alleviating nerve injury after SCIRI in rats.
Removal of Cadmium from Aqueous Solution by Magnetic Biochar: Adsorption Characteristics and Mechanism
Authors: Li Zhiwen , Niu Ruiyan , Yu Jiaheng , Yu Liyun , Cao Di 
Published: September 2023

Abstract
Experiments were conducted to investigate the potential for the efficient resource utilization of waste cow manure and corn straw in an agricultural ecosystem. In this study, magnetic biochar of cow manure and straw was synthesized by co-precipitation method, and cadmium was removed by adsorption in aqueous solution. Several physicochemical characterization techniques were applied, including scanning electron microscopy, Brunauer-Emmett-Teller (BET), Zeta potential analysis, Fourier transform infrared spectroscopy, Raman spectroscopy, X-ray photoelectron spectroscopy. The effects of pH value, magnetic biochar content, kinetics and isotherm on the adsorption of cadmium were investigated. The physicochemical characterizations revealed that the physical and chemical properties of the magnetic biochar were substantially changed compared to the unmodified biochar. The results showed that the surface of biochar became rough, the number of oxygen-containing functional groups increased, and the specific surface area increased. The results of adsorption experiments show that the adsorption capacity is affected by pH, magnetic biochar addition, cadmium concentration and adsorption time. The adsorption kinetics and isothermal adsorption experiments showed that the Cd adsorption processes of the cow manure and corn straw magnetic biochars were consistent with the Freundlich model and quasi-second-order kinetic model. The results of this study also showed that Cd adsorption effect of cow manure magnetic biochar was found to be more effective than that of corn straw magnetic biochar. In conclusion, the magnetic biochar of cow dung is an effective adsorbent for the absorption of cadmium in wastewater.
Endovascular Treatment of Intracranial Blood Blister-like Aneurysms with the Willis Covered Stent: A Single-center Experience and Review of the Literature
Authors: Jin Yazhou , Guo Xinbin , Chen Zhen , Guan Sheng 
Published: September 2023

Abstract
Background and purpose
To evaluate the safety, feasibility, and effectiveness of the Willis covered stent (WCS) in treating blood blister-like aneurysms (BBAs) and compare it with other stents in the literature.
Materials and methods
Twenty-one consecutive patients with BBAs treated with the WCS were identified between July 2017 and July 2020. The demographic, clinical, angiographic data and procedural-related complications were collected from the medical records and the operative reports. We comprehensively reviewed the related literature by searching the PubMed, Ovid MEDLINE, and Ovid EMBASE databases.
Results
The present study included six men and fifteen women, with a mean age of 51.6 years (range 31–70 years). The immediate postoperative angiography demonstrated that the complete occlusion rate was 100%, with no endoleaks. Ophthalmic artery (OA) occlusion occurred in five patients (23.8%). One patient developed delayed stent thrombosis on the third postoperative day. The mean follow-up time was 8.1 months (range 3–21 months). All twenty-one BBAs were occluded entirely, and the patency of the parent arteries was preserved. No aneurysm rupture or recurrence was found, and no retreatment was needed. Two patients developed mild to moderate asymptomatic in-stent stenosis. Twenty patients had an mRS score of zero, and one had an mRS score of one. The final analysis included 138 patients from nine articles plus our cohort. The estimated rate of immediate complete occlusion was 94% (95% confidence interval, 0.30–1.57).
Conclusions
Our series and the systematic review indicate that treating BBAs with WCSs was relatively safe and efficacious.