bluuebunny/crossref_metadata_2025_split huggingface dataset:
Philadelphia-Like Genetic Rearrangements in Adults With B-Cell ALL: Refractoriness to Chemotherapy and Response to Tyrosine Kinase Inhibitor in ABL Class Rearrangements
Authors: Senapati Jayastu , Jabbour Elias , Konopleva Marina , Short Nicholas J. , Tang Guilin , Daver Naval , Kebriaei Partow , Kadia Tapan , Pemmaraju Naveen , Takahashi Koichi , DiNardo Courtney , Sasaki Koji , Borthakur Gautam , Thakral Beenu , Kanagal-Shamanna Rashmi , Patel Keyur , Ravandi Farhad , Roberts Kathryn , Mullighan Charles , Kantarjian Hagop , Jain Nitin 
Published: May 2023

PURPOSE Philadelphia-like (Ph-like) B-cell ALL is a high-risk subtype of B-cell ALL that shares a gene expression profile with Ph-positive ALL, but without a BCR::ABL1 fusion. A subgroup of these patients have fusions or rearrangements involving genes such as ABL1, ABL2, PDGFRβ, JAK2, and EPOR, some of which are potentially sensitive to tyrosine kinase inhibitors (TKIs). Prompt identification of these genetic aberrations are important for prognostication and treatment decisions. PATIENTS AND METHODS We performed a retrospective review of patients with B-cell ALL treated at MD Anderson Cancer Center to identify recurrent genetic fusions commonly seen in Ph-like ALL and focus on patients treated with TKI. RESULTS We identified 23 patients with recurrent genetic fusions commonly seen in Ph-like ALL; 14 had ABL class fusions (eight ABL1, one ABL2, and five PDGFRβ) and nine had JAK2 class fusions (five JAK2 and four EPOR). Notably, several of these fusions were cryptic by conventional cytogenetics and fluorescent in situ hybridization (FISH) assays and identified only by multiplex fusion assay. Thirteen of these 23 patients received a TKI as part of their treatment; this included ABL1 fusion (n = 8), PDGFRβ fusion (n = 4), and EPOR fusion (n = 1). All four patients with ABL1 fusions who received TKI with induction chemotherapy are alive in first remission. CONCLUSION Understanding the genomics of B-cell ALL is important for disease prognostication and for precise treatment planning. Besides conventional cytogenetics and directed FISH testing, multiplex fusion assays can help identify recurrent chromosomal translocations that are seen in patients with Ph-like ALL. Early initiation of TKI appears beneficial; larger studies are required to fully understand the benefit of TKI and to design rational combination therapies for these patients.
Access Denied: Disparities in Thyroid Cancer Clinical Trials
Authors: Chen Debbie W , Worden Francis P , Haymart Megan R 
Published: May 2023

Abstract
For thyroid cancer clinical trials, the inclusion of participants from diverse patient populations is uniquely important given existing racial/ethnic disparities in thyroid cancer care. Since 2011, a paradigm shift has occurred in the treatment of advanced thyroid cancer with the approval of multiple systemic therapies by the US Food and Drug Administration based on their use in the clinical trials setting. Although these clinical trials recruited patients from up to 164 sites in 25 countries, the inclusion of racial/ethnic minority patients remained low. In this mini-review, we provide an overview of barriers to accessing cancer clinical trials, framed in the context of why patients with thyroid cancer may be uniquely vulnerable. Multilevel interventions and increased funding for thyroid cancer research are necessary to increase access to and recruitment of under-represented patient populations into thyroid cancer clinical trials.
A study of the effectiveness of a detergent-based California mastitis test (CMT), using Ethiopian and Nigerian domestic detergents, for the detection of high somatic cell counts in milk and their reliability compared to the commercial UK CMT
Authors: Rust Jack D. , Christian Michael J. , Vance Ciara J. , Bolajoko Muhammed B. , Wong Johanna T. , Suarez-Martinez Jeimmy , Allan Fiona K. , Peters Andrew R. 
Published: May 2023

Background: The California mastitis test (CMT) is a simple cow-side indicator of the somatic cell count (SCC) in milk, providing a useful tool in identifying cases of subclinical mastitis in cattle. Mastitis, and in particular subclinical mastitis, is a major concern in Ethiopia and Nigeria, yet detection is challenging due to cost and access to commercial CMT reagents. Methods: Commercially available domestic detergents from Ethiopia and Nigeria were compared (n = 3 for each country) with the UK commercial CMT reagent in their ability to detect high SCC (>400,000 cells/ml milk). Sensitivity and specificity of the CMT test were calculated for the different detergents and positive and negative predictive values were established. Results: The average sensitivities of the tests ranged from 28-75% for the Ethiopian detergents and 68-80% for the Nigerian detergents, compared to 76% for the UK domestic detergent. Test specificities were 84-98%, 93-97% and 96%, respectively. Conclusions: Overall, the detergents demonstrated higher specificity than sensitivity. Nigerian detergents performed better than the Ethiopian products, however, the study identified suitable domestic detergents from both Ethiopia and Nigeria, comparable to the UK commercial CMT reagent, and we recommend their use as alternative CMT reagents for livestock-keepers to aid in cost-effective diagnosis of mastitis.
Synthesis and physical characteristics of narrow bandgap chalcogenide SnZrSe3
Authors: Kondrotas Rokas , Juškėnas Remigijus , Krotkus Arūnas , Pakštas Vidas , Suchodolskis Artūras , Mekys Algirdas , Franckevičius Marius , Talaikis Martynas , Muska Katri , Li Xiaofeng , Kauk-Kuusik Marit , Kravtsov Victor 
Published: May 2023

Background: The development of organic/inorganic metal halide perovskites has seen unprecedent growth since their first recognition for applications in optoelectronic devices. However, their thermodynamic stability and toxicity remains a challenge considering wide-scale deployment in the future. This spurred an interest in search of perovskite-inspired materials which are expected to retain the advantageous material characteristics of halide perovskites, but with high thermodynamic stability and composed of earth-abundant and low toxicity elements. ABX3 chalcogenides (A, B=metals, X=Se, S) have been identified as potential class of materials meeting the aforementioned criteria. Methods: In this work, we focus on studying tin zirconium selenide (SnZrSe3) relevant physical properties with an aim to evaluate its prospects for application in optoelectronics. SnZrSe3 powder and monocrystals were synthesized via solid state reaction in 600 – 800 °C temperature range. Crystalline structure was determined using single crystal and powder X-ray diffraction methods. The bandgap was estimated from diffused reflectance measurements on powder samples and electrical properties of crystals were analysed from temperature dependent I-V measurements. Results: We found that SnZrSe3 crystals have a needle-like structure (space group – Pnma) with following unit cell parameters: a=9.5862(4) Å, b=3.84427(10) Å, c=14.3959(5) Å. The origin of the low symmetry crystalline structure was associated with stereochemical active electron lone pair of Sn cation. Estimated bandgap was around 1.15 eV which was higher than measured previously and predicted theoretically. Additionally, it was found that resistivity and conductivity type depended on the compound chemical composition. Conclusions: Absorption edge in the infrared region and bipolar dopability makes SnZrSe3 an interesting material candidate for application in earth-abundant and non-toxic single/multi-junction solar cells or other infrared based optoelectronic devices.
The influence of physical activity on reducing ADHD symptoms – a systematic review
Authors: Kotulska Maria , Jędrzejewska Barbara , Lichman Martyna , Borycka Aleksandra , Lubczyńska Zuzanna , Potocka Zofia , Przeradzki Jakub , Laskus Paulina , Rząd Katarzyna , Szyca Magda 
Published: May 2023

Introduction and objective
Attention deficit hyperactivity disorder (ADHD) is a disease affecting children and adults. Quality of life of patients suffering from ADHD is often significantly reduced. The most common treatment includes medication and psychotherapy. Although the treatment is often efficient there is still a necessity of exploring other types of therapy due to the material reasons and side effects of the medications.
The aim of the study was to asses the state of the knowledge about the influence of physical activity on the occurrence of symptoms in patients suffering from ADHD.
State of knowledge
The most common ADHD therapy is based on pharmacological agents. Mechanism of action of the drugs is often based on the inhibition of the reuptake of noradrenaline and dopamine. It leads to the enhancement in their transmission and causes the alleviation in ADHD symptoms. Many studies indicate that physical activity increases the level of catecholamines as well. The effects of physical activity on ADHD symptoms could be similar to those invoked by stimulants then. In comparison to drug therapy, physical activity is devoid of side effects and less expensive.
Methods and materials
We conducted a literature review in march 2023 using PubMed and Google Scholar databases. We used the terms “Physical activity in ADHD treatment”, “ ADHD in adults”, “ ADHD in children”, “ADHD symptoms”, “ADHD treatment”.
Summary
According to many studies physical activity seems to be efficient in reducing ADHD symptoms. The benefits are more reliable in children due to the bigger amount of conducted studies. Further clinical, randomized trials especially in a group of adults are needed to access the efficiency of physical activity as a ADHD treatment.
Caught Between a Clock and a Hard Place: Temporal Ambivalence and Time (Mis)management in Teams
Authors: Fisher Colin M. , Jang Sujin , Hackman J. Richard 
Published: May 2023

This paper examines how teams manage temporal ambivalence, or the simultaneous and conflicting perceptions of time as a resource, including how much time has passed and whether there is enough of it left. Team members’ time perceptions influence how a team manages time; thus, effective time management requires some collective resolution of temporal ambivalence. To study the effects of temporal ambivalence on time management processes and performance in teams, we conducted a laboratory study in which we manipulated perceptions of time by engineering a wall clock to run at different speeds (normal, fast, or slow) to instantiate different types of temporal ambivalence. Using both quantitative and qualitative analyses, we found that managing temporal ambivalence effectively is essential for teams to appropriately allocate time to different phases of work. Specifically, teams often misallocated their time by either transitioning too late or too early between phases of work, both of which were associated with worse team performance than transitioning closer to the temporal midpoint. Teams with heightened temporal ambivalence were more likely to manage time poorly following one or more of three dysfunctional patterns: bypassing comments, glossing over contradictions, and following passively. By contrast, teams that managed temporal ambivalence effectively did so through time management huddles, in which team members briefly and collectively took time away from the main task to explicitly discuss how to allocate their time. We discuss the implications of these findings for research on team process, ambivalence, and time management in organizations. Funding: This work was supported by Harvard University, INSEAD, and the UCL School of Management.
3 kW forward-pumped fiber laser via pump recycler
Authors: Lin Weixuan , Bussières-Hersir Marie-Hélène , Auger Mathieu , Vincelette André , Rochette Martin 
Published: May 2023

We report a single-end forward-pumped fiber laser with a record high
output power of 3 kW. The laser is assembled exclusively from
commercially widespread components such as the Yb-doped fiber with
core/cladding diameter of 20/400 µm, pump laser diodes at an
emission wavelength of 915 nm, and a signal and pump fiber
combiner that serves as the pump recycler. The record high power
arises from the combination of the 915 nm pumping and pump
recycler with an effective reflectivity of 78%, increasing
simultaneously the thresholds for stimulated Raman scattering and
transverse mode instability (TMI). The length of the oscillator was
also varied experimentally from 20 m to 5 m, showing a
contrast of up to 19% in the TMI threshold. This shows the importance
of accurately partitioning the Yb-doped fiber length in between the
oscillator and amplifier sections to minimize the impact of TMI.
Few-mode erbium-doped fiber with trench and weak coupling for mode gain equalization based on layered-doping technology
Authors: Zhao Qi , Tang Jianjun , Xie Yuheng , Feng Lipeng , Dou Tianqi 
Published: May 2023

A few-mode erbium-doped fiber (FM-EDF) with a step refractive index and
trench structure is designed and proposed to realize the modal gain
equalization of a few-mode erbium-doped fiber amplifier (FM-EDFA). The
layered-doping technology is used to reduce the mode gain difference
(DMG). The doping radius and doping concentration are adjusted to
obtain the optimum FM-EDF structure. When the designed FM-EDF is
applied to the FM-EDFA, the DMG of the whole C-band is less than
0.15 dB and the DMG is less than 0.12 dB at
1550 nm. The minimum refractive index difference (Δneff) between modes can be calculated
according to the refractive index and radius of the fiber core; i.e., 1.35×10−3, which will greatly reduce the
coupling between modes in a practical application. Tolerances in the
fiber manufacturing process are also considered for reliable FM-EDFA
performance. When the doping radius and concentration of each doping
layer fluctuate by ±15% based on the precise value, the
maximum DMG increases to 1.8 dB. In general, DMG can maintain a
small value, which is beneficial for application in optical
communications systems.
Prevalence, intensity and associated risk factors of soil-transmitted helminth infections among individuals living in Bata district, Equatorial Guinea
Authors: Ribado Meñe Gertrudis , Dejon Agobé Jean Claude , Momo Besahà Juan Carlos , Abaga Ondo Ndoho Florentino , Abdulla Salim , Adegnika Ayôla Akim 
Published: May 2023

Background
Soil transmitted Helminths (STH) infections remain a public health concern worldwide, particularly in tropical and subtropical areas where these diseases are highly endemic. Knowing the prevalence and risk factors of the disease is crucial for efficient STH control strategies in endemic areas. The scarcity of epidemiological data on STH for Equatorial Guinea has motivated the decision to perform the present study.

Methods
A cluster-based cross-sectional study was carried out in Bata district from November 2020 to January 2021. Stool samples were collected for the diagnostic of STH infections using Kato-Katz technique. Descriptive statistics was performed for determination of STH prevalence and intensity, while logistic regression models were used to assess the risk factors associated with STH infections.

Results
A total of 340 participants were included in the study with a mean age of 24 years (SD = 23.7) and 1.2 female-to-male sex-ratio. The overall prevalence of any STH was 60% (95%CI: 55–65). The most prevalent species were Ascaris lumbricoides (43%, 95%CI: 37–48) and Trichuris trichiura (40%, 95%CI: 35–46). Intensity of infection were mainly light to moderate. A trend of association was observed between age and any STH infection (overall p-value = 0.07), with a significant difference observed between children aged 5–14 years as compared to those aged 1–4 (aOR 2.12; 95%CI: 1.02–4.43, p-value = 0.04), while locality was significantly associated with STH infection (overall p-value<0.001) with a higher odds observed for peri-urban area as compared to urban area (aOR 4.57; 95%CI: 2.27–9.60, p-value<0.001).

Conclusion
Bata district is a high STH transmission area, where school-aged children and peri-urban areas are associated with a higher risk of any STH infection. This situation calls for a full implementation of the WHO recommendations for STH control; mass drug administration of anthelminthic twice a year to the whole population with great attention to school age children, and prioritizing peri-urban areas where safe water, improve sanitation, and hygiene education should be implemented to achieve a better control.
Multi-ancestry genome- and phenome-wide association studies of diverticular disease in electronic health records with natural language processing enriched phenotyping algorithm
Authors: Joo Yoonjung Yoonie , Pacheco Jennifer A. , Thompson William K. , Rasmussen-Torvik Laura J. , Rasmussen Luke V. , Lin Frederick T. J. , Andrade Mariza de , Borthwick Kenneth M. , Bottinger Erwin , Cagan Andrew , Carrell David S. , Denny Joshua C. , Ellis Stephen B. , Gottesman Omri , Linneman James G. , Pathak Jyotishman , Peissig Peggy L. , Shang Ning , Tromp Gerard , Veerappan Annapoorani , Smith Maureen E. , Chisholm Rex L. , Gawron Andrew J. , Hayes M. Geoffrey , Kho Abel N. 
Published: May 2023

Objective
Diverticular disease (DD) is one of the most prevalent conditions encountered by gastroenterologists, affecting ~50% of Americans before the age of 60. Our aim was to identify genetic risk variants and clinical phenotypes associated with DD, leveraging multiple electronic health record (EHR) data sources of 91,166 multi-ancestry participants with a Natural Language Processing (NLP) technique.

Materials and methods
We developed a NLP-enriched phenotyping algorithm that incorporated colonoscopy or abdominal imaging reports to identify patients with diverticulosis and diverticulitis from multicenter EHRs. We performed genome-wide association studies (GWAS) of DD in European, African and multi-ancestry participants, followed by phenome-wide association studies (PheWAS) of the risk variants to identify their potential comorbid/pleiotropic effects in clinical phenotypes.

Results
Our developed algorithm showed a significant improvement in patient classification performance for DD analysis (algorithm PPVs ≥ 0.94), with up to a 3.5 fold increase in terms of the number of identified patients than the traditional method. Ancestry-stratified analyses of diverticulosis and diverticulitis of the identified subjects replicated the well-established associations between ARHGAP15 loci with DD, showing overall intensified GWAS signals in diverticulitis patients compared to diverticulosis patients. Our PheWAS analyses identified significant associations between the DD GWAS variants and circulatory system, genitourinary, and neoplastic EHR phenotypes.

Discussion
As the first multi-ancestry GWAS-PheWAS study, we showcased that heterogenous EHR data can be mapped through an integrative analytical pipeline and reveal significant genotype-phenotype associations with clinical interpretation.

Conclusion
A systematic framework to process unstructured EHR data with NLP could advance a deep and scalable phenotyping for better patient identification and facilitate etiological investigation of a disease with multilayered data.
Digital tools for delivery of dementia education for caregivers of persons with dementia: A systematic review and meta-analysis of impact on caregiver distress and depressive symptoms
Authors: Scerbe Andrea , O’Connell Megan E. , Astell Arlene , Morgan Debra , Kosteniuk Julie , Panyavin Ivan , DesRoches Andrea , Webster Claire 
Published: May 2023

Continuing education for dementia has been shown to be beneficial by improving informal caregiver knowledge, dementia care, management, and caregiver physical and mental health. Technology-based dementia education has been noted to have equivalent effects as in-person education, but with the added benefit of asynchronous and/or remote delivery, which increases accessibility. Using Cochrane review methodology, this study systematically reviewed the literature on technology-based dementia education and its impacts on caregivers. Technology-based delivery included dementia education delivered via the Internet, telephone, telehealth, videophone, computer, or digital video device (DVD). In the review, twenty-eight studies were identified with fourteen included in a meta-analysis, and these data revealed a significant small effect of technologically based dementia education on reducing caregiver depression, and a medium effect on reducing caregiver distress in response to caregivers’ observations of behavioral problems displayed by persons with dementia. No evidence was found for a significant effect of the educational intervention on caregiver burden or self-efficacy, which are known to be gendered aspects of caregiving. None of the studies included in the meta-analysis reported separate outcomes for male and female care providers, which has implications for gendered caregiving norms and aspects of care.
Registration number: PROSPERO 2018 CRD42018092599.
PIK3CA mutations in breast cancer: A Tunisian series
Authors: Ben Rekaya Mariem , Sassi Farah , Saied Essya , Bel Haj Kacem Linda , Mansouri Nada , Zarrouk Sinda , Azouz Saifeddine , Rammeh Soumaya 
Published: May 2023

Background
The aim of this study was to analyze PIK3CA mutations in exons 9 and 20 in breast cancers (BCs) and their association with clinicopathological characteristics.

Methods
Mutational analysis of PIK3CA exon 9 and 20 was performed by Sanger sequencing in 54 primary BCs of Tunisian women. The associations of PIK3CA mutations with clinicopathological characteristics were analyzed.

Results
Fifteen exon 9 and exon 20 PIK3CA variants were identified in 33/54 cases (61%). PIK3CA mutations including pathogenic (class 5/Tier I) or likely pathogenic (class 4/Tier II) occurred in 24/54 cases (44%): 17/24 cases (71%) in exon 9, 5/24 cases (21%) in exon 20 and 2/24 cases (8%) in both exons. Of these 24 cases, 18 (75%) carried at least one of the three hot spot mutations: E545K (in 8 cases), H1047R (in 4 cases), E542K (in 3 cases), E545K/E542K (in one case), E545K/H1047R (in one case) and P539R/H1047R (in one case). Pathogenic PIK3CA mutations were associated with negative lymph node status (p = 0.027). Age distribution, histological SBR tumor grading, estrogen and progesterone receptors, human epidermal growth factor receptor 2, and molecular classification were not correlated with PIK3CA mutations (p > 0.05).

Conclusion
The frequency of somatic PIK3CA mutations in BCs of Tunisian women is slightly higher than that of BCs of Caucasian women and more observed in exon 9 than in exon 20. PIK3CA mutated status is associated with negative lymph node status. These data need to be confirmed in larger series.