bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ketamine as advanced second‐line treatment in benzodiazepine‐refractory convulsive status epilepticus in children
Authors: Buratti Silvia , Giacheri Emanuele , Palmieri Antonella , Tibaldi Jessica , Brisca Giacomo , Riva Antonella , Striano Pasquale , Mancardi Maria Margherita , Nobili Lino , Moscatelli Andrea 
Published: February 2023

AbstractStatus epilepticus (SE) is one of the most common neurological emergencies in children. To date, there is no definitive evidence to guide treatment of SE refractory to benzodiazepines. The main objectives of treatment protocols are to expedite therapeutic decisions and to use fast‐ and short‐acting medications without significant adverse effects. Protocols differ among institutions, and most frequently valproate, phenytoin, and levetiracetam are used as second‐line treatment. After failure of first‐ and second‐line medications, admission to the intensive care unit and continuous infusion of anesthetics are usually indicated. Ketamine is a noncompetitive N‐methyl‐D‐aspartate receptor antagonist that has been safely used for the treatment of refractory SE in adults and children. In animal models of SE, ketamine demonstrated antiepileptic and neuroprotective properties and synergistic effects with other antiseizure medications. We reviewed the literature to demonstrate the potential role of ketamine as an advanced second‐line agent in the treatment of SE. Pharmacological targets, pathophysiology of SE, and the receptor trafficking hypothesis are reviewed and presented. The pharmacology of ketamine is outlined with related properties, advantages, and side effects. We summarize the most recent and relevant publications on experimental and clinical studies on ketamine in SE. Key expert opinion is also reported. Considering the current knowledge on SE pathophysiology, early sequential polytherapy should include ketamine for its wide range of positive assets. Future research and clinical trials on SE pharmacotherapy should focus on the role of ketamine as second‐line medication.
First records of Graphocephala fennahi Young, 1977 and Pochazia shantungensis (Chou & Lu, 1977) (Hemiptera: Cicadellidae, Ricaniidae) in Russia
Authors: Zhuravleva Elena N. , Gnezdilov Vladimir M. , Tishechkin Dmitri Yu. , Mikhailenko Andrey P. , Shoshina Elena I. , Karpun Natalia N. , Musolin Dmitrii L. 
Published: February 2023

AbstractGraphocephala fennahi Young, 1977 (Cicadellidae) was observed for the first time in Russia in 2018 in Moscow City on hedge bindweed, Calystegia sepium (Convolvulaceae) and Rhododendron spp. (Ericaceae). A small population of Pochazia shantungensis (Chou & Lu, 1977) (Ricaniidae) was recorded for the first time in Russia in 2022 in Sochi City, Krasnodar Territory, on the broad‐leaf privet, Ligustrum lucidum (Oleaceae). It is likely that both species of insects were accidentally introduced with ornamental plants for planting. In total, alien Auchenorrhyncha species in Russia now comprise six species, two of which are of Asian origin (Orosanga japonica and P. shantungensis; both Ricaniidae) and four are of Nearctic origin (Stictocephala bisonia [Membracidae], Metcalfa pruinosa [Flatidae], Scaphoideus titanus and G. fennahi [both Cicadellidae]).
Taking the normative foundations of EU criminal law seriously: The legal duty of the EU to criminalise failure to rescue at sea
Authors: Guild Elspeth , Mitsilegas Valsamis 
Published: February 2023

AbstractThis contribution argues in favour of the use of Article 83(2) TFEU to adopt a Directive criminalising failure of rescue at sea. We explain how and why the EU's legal duty to comply with its obligations under Article 98 of the UN Convention on the Law of the Sea ought to translate into the adoption of a Directive requiring Member States to criminalise all action contrary to Article 98 UNCLOS on the basis of Article 83(2) TFEU. The criminalisation of failure to rescue at sea would not only allow for the EU to abide by the fundamental legal rules that shape its order but also be consistent with the two rationales that have guided European integration so far: a functional rationale, whereby the Union has competence to adopt criminal offences and impose criminal sanctions where approximation proves essential to ensuring the effective implementation of a Union policy in an area which has been subject to harmonisation measures, and a constitutional rationale, according to which criminal law is key to ensuring respect for EU common values and fundamental rights.
Relational concerns and change in relationship satisfaction in a relationship education program
Authors: Kanter Jeremy B. , Lannin Daniel G. , Rauer Amy J. , Yazedjian Ani 
Published: February 2023

AbstractLower income couples tend to report more difficulty sustaining high‐quality intimate relationships. As a result, policy initiatives have been enacted to fund relationship education (RE) programs that aim to increase lower income couples' relationship satisfaction. Generally, these programs demonstrate small, albeit statistically significant improvements in mean levels of relationship functioning. It is critical, however, to understand if RE programming influences the developmental course of intimate relationships, and if this influence depends on couples' initial levels of concerns about their relationships. Using dyadic group‐based modeling and three waves of data from 6034 couples in the Supporting Healthy Marriages project, a randomized control trial of RE, we categorized couples into four relationship concern groups (No Relational Concerns, Both Relationally Concerned, Men's Relational Concerns, and Women's Relational Concerns) and explored how these groups moderated the long‐term efficacy of RE programming. Results indicated that RE was associated with different developmental trajectories of satisfaction, but RE effects differed for men and women. Specifically, random assignment into RE was associated with men maintaining high levels of relationship satisfaction, whereas women's satisfaction decreased over time. These effects were not moderated by initial relationship concerns. The association between RE and relationship satisfaction trajectories was small in magnitude, suggesting that more comprehensive services are needed to strengthen lower income couples' intimate relationships.
Changes in migraine interictal burden following treatment with galcanezumab: Results from a phase III randomized, placebo‐controlled study
Authors: Lipton Richard B. , Buse Dawn C. , Sandoe Claire H. , Ford Janet H. , Hand Austin L. , Jedynak Jakub P. , Port Martha D. , Detke Holland C. 
Published: February 2023

AbstractObjectiveTo evaluate changes in interictal burden with galcanezumab versus placebo in patients with episodic (EM) or chronic migraine (CM).BackgroundThe disruptive effects of migraine occur both during attacks (ictal period) and between attacks (interictal period), affecting work, school, family, and social life. Migraine clinical trials typically assess ictal burden endpoints, neglecting interictal burden.MethodsCONQUER was a 3‐month, double‐blind study that randomized adult patients with EM or CM who had experienced failure of two to four standard‐of‐care migraine preventive medication categories to receive monthly galcanezumab (n = 232) or placebo (n = 230), followed by 3 months of open‐label galcanezumab. The mean change in interictal burden, a secondary objective, was measured using the four‐item Migraine Interictal Burden Scale (MIBS‐4). The total score for MIBS‐4 can range from zero to 12, with scores ≥5 indicating severe interictal burden. Post hoc analyses evaluated shifts in MIBS‐4 severity categories and item‐level improvement.ResultsThe MIBS‐4 total score indicated severe interictal burden at baseline (mean [SD]: all patients, 5.5 [3.5]; EM, 5.0 [3.4]; CM, 6.2 [3.5]). Reductions in the MIBS‐4 score were significantly greater with galcanezumab versus placebo at Month 3 (mean [SE]: all patients −1.9 [0.2] vs. −0.8 [0.2], p < 0.0001; EM, −1.8 [0.3] vs. −1.1 [0.3], p = 0.033; CM, −1.8 [0.4] vs. −0.3 [0.4], p < 0.001), with further improvement at Month 6 after all patients had received galcanezumab (mean [SE]: all patients, −2.4 [0.2] vs. −2.0 [0.2]; EM, −2.3 [0.3] vs. −2.2 [0.3]; CM, −2.1 [0.4] vs. −1.5 [0.4]). The percentage of patients with severe interictal burden decreased substantially for the galcanezumab‐treated patients, from 59% (137/232) at baseline to 27% (58/217) at Month 6 (EM from 51% [70/137] to 23% [30/131]; CM from 71% [67/95] to 33% [28/86]).ConclusionIn addition to the known efficacy of galcanezumab in the ictal period, these findings suggest treatment with galcanezumab results in a significant reduction in interictal burden.
Crystal structure and magneto‐dielectric properties of Co‐Zr co‐substituted Co2Z hexaferrites
Authors: Huo Xingyu , Su Hua , Zhang Qin , Huang Fangyi , Wu Xiaohui , Li Yuanxun , Jian Xian , Jing Yulan 
Published: February 2023

AbstractA series of Ba1.5Sr1.5Co2+xZrxFe24‐2xO41 hexaferrites (x = 0.00, 0.01, 0.03, 0.05, 0.07, and 0.09) were successfully prepared by the conventional solid‐state reaction method. It was found that as the Co2+ and Zr4+ ions entered the hexaferrite structure, the lattice parameters increased, whereas the relative density increased when x = 0.00‐0.03 and then decreased. A suitable amount of substitution increased the DC resistivity, reduced the magnetic and dielectric losses, and made the and closer to each other. At x = 0.03, the relative density and DC resistivity of the samples reached their maxim. Besides, both the magnetic and dielectric losses were lowest within the frequency range of 10 MHz‐1 GHz. Meanwhile, the hexaferrite was impedance matched to free space, and the miniaturization factor was about 15. Therefore, this low‐loss ferrite with almost equal permeability and permittivity could be meaningful for antenna miniaturization and high‐frequency applications.
Student diversity and e‐exam acceptance in higher education
Authors: Froehlich Laura , Sassenberg Kai , Jonkmann Kathrin , Scheiter Katharina , Stürmer Stefan 
Published: February 2023

AbstractBackgroundThe use of e‐exams in higher education is increasing. However, the role of student diversity in the acceptance of e‐exams is an under‐researched topic. In the current study, we considered student diversity in terms of three sociodemographic characteristics (age, gender, and second language) and three dispositional student characteristics (computer anxiety, test anxiety, and technology openness).ObjectivesThe main objective of this study was to investigate the relationship between student diversity and acceptance of e‐exams.MethodsOur research combined cross‐sectional analyses (N = 1639) with data from a natural experiment on the introduction of e‐exams versus the established paper‐pencil exams (N = 626) and used both self‐report and institutional data. Sociodemographic and dispositional characteristics were indirectly related to pre‐exam acceptance via expectancy variables from the Technology Acceptance Model framework.Results and ConclusionsComparisons of post‐exam acceptance showed that practical experience with the e‐exam led to a significant increase in e‐exam acceptance, and that students with low openness toward technology particularly benefited from this effect. Students' exam performance (i.e., grades) was unrelated to the exam format or their pre‐exam acceptance of the e‐exam format, and this was true across students' sociodemographic and dispositional characteristics.TakeawayStudent diversity plays a role in e‐exam acceptance, but its influence is mitigated by first‐hand experience with e‐exams. The practical implications for higher education institutions aiming to implement e‐exams are discussed.
Feeding ecology of redfish (Sebastes sp.) inferred from the integrated use of fatty acid profiles as complementary dietary tracers to stomach content analysis
Authors: Brown‐Vuillemin Sarah , Tremblay Réjean , Chabot Denis , Sirois Pascal , Robert Dominique 
Published: February 2023

AbstractIn the northern Gulf of St. Lawrence (nGSL), redfish (Sebastes mentella and Sebastes fasciatus combined) are at record levels of abundance following the strong recruitment of three consecutive cohorts in 2011–2013 and have become by far the most abundant demersal fish in the region. Understanding redfish trophic relationships is essential for the effective management and conservation of species in the nGSL ecosystem. To date, description and quantification of redfish diet in the region have been restricted to conventional stomach content analysis (SCA). Using analysis of fatty acid (FA) profiles as complementary dietary tracers, the authors conducted multivariate analyses on 350 livers of redfish which were collected in combination with stomach contents during a bottom‐trawl scientific survey in August 2017. The predator FA profiles were compared to those of eight different redfish prey types identified as dietary important with SCA. Results suggested similitude between SCA and FA results, with zooplankton prey being more related to small (<20 cm) and medium (20–30 cm) redfish (16:1n7, 20:1n?, 22:1n9 and 20:5n3) than large (≥30 cm) ones, whereas shrimp prey seemed more related to large redfish size classes (18:2n6 and 22:6n3) relative to the small and medium ones. Although the SCA offers a glimpse in the diet only based on the most recently consumed prey, analysis of FA profiles provides a mid‐term view indicating pelagic zooplankton consumption on calanoid copepod and confirming high predation pressure on shrimp. This study constitutes the first attempt of combining FA with SCA to assess the diet of redfish, highlights the benefits of FA as a qualitative tool and suggests improvements for future studies.
Nutritional practices and dietetic provision in the endometriosis population, with a focus on functional gut symptoms
Authors: Deepak Kumar Komal , Appleby‐Gunnill Bridie , Maslin Kate 
Published: February 2023

AbstractBackgroundEndometriosis is a common condition causing chronic pain, fatigue and gut symptoms. Research suggests that dietary changes may improve symptoms; however, evidence is lacking. The present study aimed to investigate the nutritional practices and needs of individuals with endometriosis (IWE) and the management of endometriosis by dietitians in the UK, focusing on gut symptoms.MethodsTwo online questionnaires were distributed via social media: a survey of dietitians working with IWE and functional gut symptoms and a survey of IWE.ResultsAll respondents to the dietitian survey (n = 21) used the low fermentable oligosaccharides disaccharides monosaccharides and polyols (FODMAP) diet in IWE, with the majority 69.3% (n = 14), reporting positive adherence and patient benefit. Dietitians recommended more training (85.7%, n = 18) and resources (81%, n = 17) for IWE. Of those who completed the IWE questionnaire (n = 1385), 38.5% (n = 533) had coexisting irritable bowel syndrome. Only 24.1% (n = 330) had satisfactory relief of gut symptoms. The most common symptoms were tiredness, bloating and abdominal pain, experienced by 85.5% (n = 1163), 75.3% (n = 1025) and 67.3% (n = 917), respectively. Some 52.2% (n = 723) had tried dietary modifications to relieve their gut symptoms; 36.7% (n = 500) ate a restricted diet at present; 13.5% (n = 184) experienced recent unintentional weight loss and 29.8% (n = 407) a decreased appetite Some 13.2% (n = 183) had seen a dietitian regarding their gut symptoms. Of those who had not seen a dietitian, 57.7% (n = 693) would find it useful to.ConclusionsGut symptoms and dietary restriction are very common in IWE; however, dietetic input is not. More research on the role of nutrition and dietetics in the management of endometriosis is recommended.
Equipping nutrition graduates for the complex realities of practice: Using practitioner perspectives and experiences to inform authentic sustainability curriculum
Authors: Maher Judith , Ashford Theresa , Verdonck Michèle , English Elizabeth , Burkhart Sarah 
Published: February 2023

AbstractBackgroundNutrition professionals function at the nexus of food, nutrition status and the myriad of determinants influencing these. However, defining our role in food system transformation requires a multifaceted and deep understanding of sustainability in the context of nutrition and dietetics (N&D). Practitioner perspectives and experiences provide a rich source of practice wisdom that can inform authentic curriculum to equip students for the complex realities of practice; however, there is limited understanding of these in the Australian higher education setting.MethodsQualitative methodology using semistructured interviews with 10 Australian N&D professionals. Thematic analysis was used to understand how they perceive opportunities and barriers for integrating sustainability into practice.ResultsPractitioners' experience in sustainability practice varied. Themes were identified in two categories: opportunities and barriers. Themes that reflected future practice opportunities included “Preparing the workforce” (for academics and practitioners interfacing with students), “Practical individual level work” and “System level and policy interests”. Themes that were considered barriers to integrating sustainability in practice included “lack of contextual evidence” and “complexity and competing priorities”.ConclusionsOur findings make a novel contribution to the current literature as we recognise practitioners as a source of experience anticipating where sustainability and nutrition practice intersect. Our work provides practice‐informed content and context that may assist educators to create authentic sustainability‐focused curriculum and assessment to replicate the complexity of practice.
Investor visits to corporate sites and cost stickiness
Authors: Yao Wenyun , Xu Hanwen , Fan Yuling , Xu Zefeng 
Published: February 2023

AbstractA corporate site visit is an effective way to obtain information on a firm. Most studies focus on the information advantages of corporate site visits, but evidence of their impact on firm operations is limited. In this paper, we investigate whether investors’ corporate site visits affect cost stickiness. Using data on investor corporate site visits to Chinese listed firms from 2013 to 2018, we find that these visits can inhibit cost stickiness. This finding holds in robustness tests and when controlling for endogeneity, including firm fixed effects, and using the Heckman selection model and the instrumental variables method. Further analyses reveal this inhibition is more pronounced for nonstate‐owned enterprises and the results are more significant regarding cost stickiness in firms consuming nonlabor materials and firms visited by institutional investors. Moreover, we explore plausible mechanisms through which corporate site visits inhibit cost stickiness, such as through a monitoring channel and a learning channel. Our study contributes to academic evidence on the benefit and value of corporate site visits to firm operations, showing these visits can be a useful way to build connections between investors and firms.
Intramuscular aponeuroses and fiber bundle morphology of the five bellies of flexor digitorum superficialis: A three‐dimensional modeling study
Authors: Campisi Emma Stefanie , Johnston Mai‐Lan , Kelly Ellis Caitlin , Tran John , Switzer‐McIntyre Sharon , Agur Anne Maria Reet 
Published: February 2023

AbstractRestoring balanced function of the five bellies of flexor digitorum superficialis (FDS) following injury requires knowledge of the muscle architecture and the arrangement of the contractile and connective tissue elements. No three‐dimensional (3D) studies of FDS architecture were found in the literature. The purpose was to (1) digitize/model in 3D the contractile/connective tissue elements of FDS, (2) quantify/compare architectural parameters of the bellies and (3) assess functional implications. The fiber bundles (FBs)/aponeuroses of the bellies of FDS were dissected and digitized (MicroScribe® Digitizer) in 10 embalmed specimens. Data were used to construct 3D models of FDS to determine/compare the morphology of each digital belly and quantify architectural parameters to assess functional implications. FDS consists of five morphologically and architecturally distinct bellies, a proximal belly, and four digital bellies. FBs of each belly have unique attachment sites to one or more of the three aponeuroses (proximal/distal/median). The proximal belly is connected through the median aponeurosis to the bellies of the second and fifth digits. The third belly exhibited the longest mean FB length (72.84 ± 16.26 mm) and the proximal belly the shortest (30.49 ± 6.45 mm). The third belly also had the greatest mean physiological cross‐sectional area, followed by proximal/second/fourth/fifth. Each belly was found to have distinct excursion and force‐generating capabilities based on their 3D morphology and architectural parameters. Results of this study provide the basis for the development of in vivo ultrasound protocols to study activation patterns of FDS during functional activities in normal and pathologic states.
Factors associated with burnout among hospital‐based healthcare workers during the COVID‐19 pandemic: A cross‐sectional CRACoV‐HHS study
Authors: Szczerbińska Katarzyna , Barańska Ilona , Kijowska Violetta , Stodolska Agata , Wójcik Grzegorz , Różańska Anna , Wójkowska‐Mach Jadwiga 
Published: February 2023

AbstractAimsTo assess the prevalence of burnout and associated factors among healthcare workers (HCWs) working in a hospital admitting patients with COVID‐19.BackgroundBurnout among HCWs is related to age, gender and occupation. However, little is known about organisational factors associated with burnout during the COVID‐19 pandemic.DesignA cross‐sectional study of 1412 hospital HCWs (748 nurses) was carried out via online survey during the COVID‐19 pandemic between 4 and 19 January 2021.MethodsThe Maslach Burnout Inventory‐Human Services Survey, the Checklist Individual Strength questionnaire, the interRAI items covering mental health, the WHO questionnaire items assessing HCWs' preparedness and exposure to SARS‐CoV‐2 were used. Univariable and multivariable linear regression analyses were conducted to clarify factors associated with emotional exhaustion (EE), depersonalisation (DP) and personal accomplishment (PA). This study adheres to the STROBE guidelines.ResultsBurnout prevalence varied from 10.0% to 22.0%. Most respondents (83.6%) reported low PA, 22.9% high EE and 18.7% high DP. Nurses and physicians had the highest levels of EE and DP. Staff exposed or uncertain if exposed to contaminated patients' body fluids and materials had higher levels of burnout. Preparedness (training) (b = 1.15; 95%CI 0.26 to 2.05) and adherence to infection prevention and control procedures (b = 1.57; 95%CI 0.67 to 2.47) were associated with higher PA, and accessibility of personal protective equipment (PPE) (b = −1.37; 95%CI ‐2.17 to −0.47) was related to lower EE. HCWs working in wards for patients with COVID‐19 reported lower EE (b = −1.39; 95%CI ‐2.45 to −0.32). HCWs who contracted COVID‐19 reported lower DP (b = −0.71, 95%CI ‐1.30 to −0.12).ConclusionsOrganisational factors such as better access to PPE, training, and adherence to infection prevention and control procedures were associated with a lower level of burnout.Relevance to clinical practiceHealthcare managers should promote strategies to reduce burnout among HCWs with regard to preparedness of all staff.