bluuebunny/crossref_metadata_2025_split huggingface dataset:
The m6A methyltransferase METTL16 inhibits the proliferation of pancreatic adenocarcinoma cancer cells via the p21 signaling pathway
Authors: Xie Fuming , Zheng Yao , Fu Wen , Chi Bojing , Wang Xianxing , Zhang Junfeng , Gu Jianyou , Yin Jingyang , Zhou Qiang , Guo Shixiang , Cai Lei , Yang Jiali , Liu Songsong , Wang Huaizhi 
Published: April 2023

BackgroundMany studies have reported that N6-methyladenosine (m6A) modification plays a critical role in the epigenetic regulation of organisms and especially in the pathogenesis of malignant diseases. However, m6A research has mainly focused on methyltransferase activity mediated by METTL3, and few studies have focused on METTL16. The aim of this study was to investigate the mechanism of METTL16, which mediates m6A modification, and its role in pancreatic adenocarcinoma (PDAC) cell proliferation.MethodsClinicopathologic and survival data were retrospectively collected from 175 PDAC patients from multiple clinical centers to detect the expression of METTL16. CCK-8, cell cycle, EdU and xenograft mouse model experiments were used to evaluate the proliferation effect of METTL16. Potential downstream pathways and mechanisms were explored via RNA sequencing, m6A sequencing, and bioinformatic analyses. Regulatory mechanisms were studied through methyltransferase inhibition, RIP, MeRIP‒qPCR assays.ResultsWe found that METTL16 expression was markedly downregulated in PDAC, and multivariate Cox regression analyses revealed that METTL16 was a protective factor for PDAC patients. We also demonstrated that METTL16 overexpression inhibited PDAC cell proliferation. Furthermore, we identified a METTL16-p21 signaling axis, with downregulation of METTL16 resulting in inhibition of CDKN1A (p21). Additionally, METTL16 silencing and overexpression experiments highlighted m6A modification alterations in PDAC.ConclusionsMETTL16 plays a tumor-suppressive role and suppresses PDAC cell proliferation through the p21 pathway by mediating m6A modification. METTL16 may be a novel marker of PDAC carcinogenesis and target for the treatment of PDAC.
The duration of untreated psychosis among U.S. Latinxs and social and clinical correlates
Authors: Santos Maria M. , Kratzer Maya , Zavala Jaqueline , Lopez Daisy , Ullman Jodie , Kopelowicz Alex , Lopez Steven Regeser 
Published: April 2023

PurposeThis study (a) documents the duration of untreated psychosis (DUP) and (b) examines both social and clinical correlates of DUP in a sample of U.S. Latinxs with first-episode psychosis (FEP).MethodsData were collected for a longitudinal study evaluating a community education campaign to help primarily Spanish-speaking Latinxs recognize psychotic symptoms and reduce the DUP, or the delay to first prescribed antipsychotic medication after the onset of psychotic symptoms. Social and clinical variables were assessed at first treatment presentation. A sequential hierarchical regression was conducted using √DUP to identify independent predictors of the DUP. A structural equation model was used to explore the association between DUP predictors, DUP, and clinical and social correlates.ResultsIn a sample of 122 Latinxs with FEP, the median DUP was 39 weeks (M = 137.78, SD = 220.31; IQR = 160.39–5.57). For the full sample, being an immigrant and having self-reported relatively poor English-speaking proficiency and self-reported strong Spanish-speaking proficiency were related to a longer delay to first prescribed medication after psychosis onset. For the immigrant subgroup, being older at the time of migration was related to a longer delay. Self-reported English-speaking proficiency emerged as an independent predictor of the DUP. Although the DUP was not related to symptomatology, it was associated with poorer social functioning. Low self-reported English-speaking ability is associated with poorer social functioning via the DUP.ConclusionLatinxs with limited English language skills are especially at high risk for experiencing prolonged delays to care and poor social functioning. Intervention efforts to reduce the delay in Latinx communities should pay particular attention to this subgroup.
The relationship between childhood asthma and socioeconomic status: a Korean nationwide population-based study
Authors: Lee Won Seok , Hwang Jae Kyoon , Ryu Jiin , Choi Young-Jin , Oh Jae-Won , Kim Chang-Ryul , Han Man Yong , Oh In Hwan , Lee Kyung Suk 
Published: April 2023

PurposeThis study aimed to investigate associations of socioeconomic status (SES) with asthma exacerbation and asthma-related hospital utilization factors among children with asthma in the Republic of Korea.MethodsThis study retrospectively analyzed population-level data from the Korean National Health Insurance Service, collected from 2013 through 2019. SES was classified into five categories according to the national health insurance premiums quantiles (0 [lowest] to 4 [highest]). The hazard ratios (HRs) for asthma exacerbation, emergency department (ED) visits, hospital admission, and intensive care unit (ICU) admission were analyzed with respect to SES.ResultsAmong the five SES groups, SES group 0 (medical aid), had the highest tallies and proportions of children who experienced asthma exacerbations (n = 1,682, 4.8%), ED visits (n = 932, 2.6%), hospital admission (n = 2,734, 7.7%) and ICU admission (n = 14, 0.04%). Compared with SES group 4, SES group 0 had adjusted HRs of 3.73 (p = 0.0113) and 1.04 (p &lt; 0.0001) for ventilator support/tracheal intubation and administration of systemic corticosteroids, respectively. Relative to group 4, the adjusted HRs for ED visits, hospital admission, and ICU admission in group 0 were 1.88 (p &lt; 0.0001), 2.20 (p &lt; 0.0001), and 7.12 (p &lt; 0.0001), respectively. In the survival analysis, group 0 had a significantly higher risk of ED presentation, hospital admission, and ICU admission than the other groups (log-rank p &lt; 0.001).ConclusionCompared with children of higher SES, those in the lowest SES group had increased risk of asthma exacerbation, hospital admission, and receiving treatment for severe asthma symptoms.
Perspectives from research and practice: A survey on external load monitoring and bone in sport
Authors: Scott Reece , James Ruth , Barnett Cleveland T. , Sale Craig , Varley Ian 
Published: April 2023

IntroductionThere is limited information regarding the association between external load and estimated bone load in sport, which may be important due to the influence exercise can have on bone accrual and injury risk. The aim of this study was to identify external load measuring tools used by support staff to estimate bone load and assess if these methodologies were supported in research.MethodsA survey was comprised of 19 multiple choice questions and the option to elaborate on if/how they monitor external load and if/how they used them to estimate bone load. A narrative review was performed to assess how external load is associated to bone in research.ResultsParticipants were required to be working as support staff in applied sport. Support staff (n = 71) were recruited worldwide with the majority (85%) working with professional elite athletes. 92% of support staff monitored external load in their organisation, but only 28% used it to estimate bone load.DiscussionGPS is the most commonly used method to estimate bone load, but there is a lack of research assessing GPS metrics with bone load. Accelerometry and force plates were among the most prevalent methods used to assess external load, but a lack of bone specific measurements were reported by support staff. Further research exploring how external load relates to bone is needed as there is no consensus on which method of external load is best to estimate bone load in an applied setting.
Effects of workplace stress, perceived stress, and burnout on collegiate coach mental health outcomes
Authors: Wright Simon A. , Walker Lauren F. , Hall Eric E. 
Published: April 2023

IntroductionGiven the continuously changing job demands of coaches, coach burnout continues to be an important area of study. Coaching literature highlights the role occupational stressors play in the development and management of burnout. However, research highlights the potential need for the field to differentiate feelings of burnout from those of other sub-clinical mental health indicators (e.g., anxiety, depression). This study sought to examine the relationship between workplace stress, perceived stress, coach burnout, coach well-being, and sub-clinical health issues (anxiety, stress, depression).MethodsOne hundred forty-four NCAA collegiate coaches completed online questionnaires measuring the proposed variables. Structural equation modeling was used to test the proposed hypothesis that burnout would serve as a partial mediator between workplace and perceived stress and mental health indicators (e.g., depression, anxiety, stress, and well-being).ResultsWorkplace stress and perceived stress were positively associated with both burnout subscales. Additionally, perceived stress alone exhibited a positive association with depression, anxiety, and stress and a negative association with well-being. While there was a positive significant relationship between disengagement and depression in the model and a negative significant relationship between disengagement and well-being, most relationships between the two burnout subscales and mental health outcomes were negligible.DiscussionIt can be concluded that while workplace and perceived life stressors may impact feelings of burnout and mental health indicators directly, burnout does not appear to exhibit a strong effect on perceptions of mental health and well-being. In line with other research studies, it may be worth considering whether burnout should be considered another type of clinical mental health issue instead of as a direct contributor to coach mental health.
حق السيطرة على البضائع في القانون الإماراتي وقواعد روتردام
Authors: القهالي فؤاد 
Published: April 2023

يناقش هذا البحث حق السيطرة وفقاً لقواعد روتردام، والقانون التجاري البحري الإماراتي رقم (26) لسنة 1981م، حق المرسل والمرسل إليه في إصدار تعليمات للناقل بشأن البضائع، وقد قسمت الموضوع إلى مبحثين، المبحث الأول بعنوان ماهية حق السيطرة للبضائع المنقولة بحراً، وأما المبحث الثاني فيتناول حقوق والتزامات الطرف المسيطر على البضائع المنقولة بحراً.
وقد خلصت الدراسة إلى العديد من النتائج والتوصيات منها: أن حق المرسل في توجيه البضائع والتصرف فيها أثناء الرحلة البحرية، لا يكون مرتبطاً بحق الملكية الوارد على البضاعة؛ بسبب استقلالهما، فالملكية تنتقل أثناء عملية النقل وفقاً للقواعد العامة، ولا يتدخل الناقل في ذلك، سوى ما يتعلق بالمرسل إليه نتيجة انتقال الملكية، أما الحق في السيطرة فهو عبارة عن الحق في تغيير خط سير البضائع.
كما توصلت الدراسة إلى أن المشرع الإماراتي لم ينظم حق السيطرة بشكل دقيق كما هو الحال بالنسبة لاتفاقية روتردام، وترتيباً على ذلك نقترح عليه النص على ذلك الحق بشكل صريح وتنظيمه نظراً لأهميته.
programa “Roda Viva” e algumas memórias de outrora
Authors: Pereira Isac dos Santos 
Published: April 2023

Enquanto a Arte/educação modernista liberou o ensino do fazer Arte tradicionalista, o movimento pós-moderno foi refletido e inserido dentro do campo da educação como uma epistemologia que passou a nortear a aprendizagem dos educandos, enfatizando não somente mais os fatores endógenos, afeitos ao modernismo, mas também os fatores exógenos. Partindo de tal pressuposto, o presente artigo visa salientar e defender a ideia de que o programa “Roda Viva” exibido em 1998 e disponível no YouTube como memória registrada, tendo a participação de Ana Mae Barbosa e diversos convidados, foi uma forma cabal de confirmar a passagem do movimento modernista para o pós-modernista, evidenciando não somente mais um único meio democrático como parte fundante na transmissão do saber, no entanto inserindo também o audiovisual como elemento pertencente à esse novo tipo de ensino, além de comprovar a necessidade premente de tal mídia na formação continuada do Arte/Educador.
Development of local democracy in the system of reforming public administration
Authors: Ruban Dmytro 
Published: April 2023

Introduction. The multifaceted nature of the processes of reforming public administration determines the relevance of conducting a comprehensive study of the development processes of local democracy as one of the key directions. Among the main focuses of scientific research on the development of the system of public administration and local self- government is the identification of the main problems and obstacles, taking into account the priorities of European integration and the processes of European integration.Purpose. The purpose of the study is to understand the meaning of the concepts “democracy” and “local democracy” from the standpoint of forming systemic conditions for their spread worldwide and ensuring the full development of local democracy in Ukraine.Methods. To achieve the goal, the following methods were used: as a historical analysis, synthesis, and analogies - for the study of the conceptual apparatus; analysis, grouping, and tabular methods - in tracking the processes of the spread of democracy and its resource provision for the development of local democracy.The works of Ukrainian and foreign scientists, reports of international analytical agencies, and domestic legislation form the research information base.Results. Approaches to understanding are revealed, and the relationship between “democracy” and “local democracy” as the basis of modern concepts of social development is determined. Emphasis is placed on the systematization of the basic provisions of the concept of local democracy. The processes of the spread of democracy in the world are analyzed according to the typology of countries according to the level of development of democracy. The structure of government expenditures by levels of management was studied. Countries are grouped according to the distribution of costs between levels of public administration. The peculiarities of the development of local democracy in Ukraine are revealed under the main problems and challenges caused by the war.Prospects. Further research should investigate the development processes of local democracy in the context of ensuring the post-war renewal of Ukraine’s regions and the fulfillment of tasks to ensure accelerated integration into the EU. In this context, an in-depth study of the experience of EU countries and the development of tools for the implementation of strategic tasks following the peculiarities of Ukraine are essential.
From Perfect Secrecy to Perfect Safety & Security: Cryptography-Based Analysis of Endogenous Security
Authors: Jin Liang , Hu Xiaoyan , Wu Jiangxing 
Published: April 2023

<p>In this paper, we propose a conjecture that endogenous security without any prior knowledge is similar to perfect secrecy without any prior knowledge. To prove the conjecture, we first establish a cryptography model of instinct function security to transform the security problem in the network domain into an encryption problem in the cryptographic domain. Then, we inherit and apply the established ideas and means of the Perfect Secrecy, and propose the concept, definition and corollaries of the perfect instinct function security (PIFS) corresponding to the Perfect Secrecy. Furthermore, we take the DHR system as a concrete implementation of PIFS and propose the DHR Perfect Security Theorem corresponding to Shannon’s Perfect Secrecy Theorem. Finally, we prove that the DHR satisfying the "One-Time Reconstruction" constraint is the sufficient and necessary condition to achieve perfect security. This means that the existence of PIFS is also proven.</p>
<p>The analysis shows that any reconfigurable system can be encrypted by its construct and that the PIFS converts the one-way transparent superiority of the attacker into a double-blind problem for both the attacker and the defender, which leads to that the attacker is impossible to obtain useful construction information from the attacks and unable to find a better way than blind trial-and-error or brute-force attacks. </p>
<p>Since the attackers are required to have the new powerful ability to crack the structure cryptogram, the threshold of cyber security is raised to at least the same level as cryptogram deciphering, thereafter the ubiquitous cyber threats are destined to be significantly reduced.</p>
ESTIMATING THE SUSTAINABILITY OF AI MODELS BASED ON THEORETICAL MODELS AND EXPERIMENTAL DATA
Authors: Gitzel Ralf 
Published: April 2023

<p> As deep learning AI becomes more and more common in business and even in our daily lives, it is important to understand what the carbon impact of this type of software is. Recent papers have shown that it can be quite great, i.e., the training of a single high-end model can result in emissions of more than 500t of CO2eq. In this article we describe a life-cycle-focused framework to estimate the carbon drivers of a new deep learning model. We experimentally verify some claims in the literature and provide suggestions on how to reduce the carbon footprint of a deep learning-based offering. The article should enable developers and managers to make informed and meaningful decisions to minimize their ML projects’ sustainability impact. </p>
Mitigating IBR Trips During Grid Disturbances Using Low Risk Control Approaches
Authors: Pattabiraman Dinesh 
Published: April 2023

<p>Trips of inverter-based resources (IBR) have been observed more commonly during grid disturbance events in power systems. Such events have caused concerns due to the high penetration of IBRs and the magnitude of recent trip events. Inverter trips could potentially compromise system reliability due to loss of generation from resources. In this work, some major causes of inverter trips are explained and the root cause behind these trips are analyzed. While the performance of the inverter can vary with manufacturer, there are some underlying aspects of these trips that could be common to the industry. The link between the trips and resource behavior, physical limits and grid requirements are analyzed. Some approaches to mitigate such trips are proposed and simulation results are presented to validate the approach. The approaches proposed are deemed low risk since the changes proposed are rather simplistic and reduce the risk of inverter reaching a physical limit during grid disturbances. </p>
Photoelectric Effect to Photowaves Phenomena --- New Phenomena Requiring Interpretation
Authors: peng hui 
Published: April 2023

<p>The classical interpretation of Young’s double slit experiment is that, before and after passing through the diaphragm of the double slit, the light behaves as waves. Feynman called the double slit experiment “the only mystery [of quantum mechanics]. We propose for the first time both the photon chamber and Postulates of convex lens, and utilize both to the classical wave experiments. Experiments show new phenomena that, in the same experiments: (1) the non-interference patterns near the diaphragm and interference patterns near the screen coexist; (2) the non-interference patterns evolve to the interference patterns; (3) the interference patterns and the non-interference patterns are produced independently and partially; (4) the light is not EM waves. The light is photons not only in Photoelectric effect but also in the classical wave experiments, and the photons distribute as waves near and on the screen, we referred the phenomena as Photowaves. The experimental results in this article are consistent. New phenomena require an interpretation.</p>
ABAEKS: Attribute-Based Authenticated Encryption with Keyword Search over Outsourced Encrypted Data
Authors: Luo Fucai , Wang Haiyan , Yan Xingfu 
Published: April 2023

<p>The widespread adoption of cloud computing and the exponential growth of data highlight the need for secure data sharing and querying. Attribute-based keyword search (ABKS) has emerged as an efficient means of searching encrypted data stored in the cloud. However, existing ABKS schemes are vulnerable to quantum computer attacks, (insider) keyword guessing attacks (KGA), or incur high end-to-end delay. To address these vulnerabilities, this paper introduces a new concept called attribute-based authenticated encryption with keyword search (ABAEKS) and proposes an efficient ABAEKS scheme. Our ABAEKS has low end-to-end delay, and is resistant to both quantum computer attacks and (insider) KGA. In addition, we formalize the security model of ABAEKS system and prove its security in the random oracle model. Finally, we conduct a comprehensive performance evaluation of ABAEKS, and the experimental results show that our ABAEKS is computationally efficient and outperforms current state-of-the-art ABKS schemes. </p>
Mathematical Modelling of Device Currents in Space-Vector Modulated Two-Level Three-Phase Voltage Source Inverter
Authors: Mirdoddi Kaushik , Nag Soumya Shubhra 
Published: April 2023

<p>Accurate calculation of losses incurred in the power electronics converter is particularly essential in selection of devices and optimal thermal design. Conduction losses are mainly dependent on the currents flowing through the device. This article attempts to devise device current expressions in a space vector modulated (SVM) voltage source inverter (VSI). Emphasis is laid on deriving the equations which facilitate for quick and accurate calculation of conduction losses in the converter at different load conditions. Importance of the proposed work also lies in providing a generic way of mathematical modelling of device currents in complex pulse-width modulation (PWM) schemes. Initially, device currents in SVM inverter without considering dead-time was presented, where a generalized expression for offset voltage is derived. As dead-time is absolutely essential for safe operation of devices, effect of dead-time consideration on device currents is discussed. Finally, as channel of MOSFETs can conduct bidirectionally, the device currents considering reverse conduction of MOSFETs is presented. Simulation analysis is performed using MATLAB/SIMULINK®. The effectiveness of the derived expressions is also validated experimentally using 415 V, 5 kW SiC MOSFET based voltage source inverter setup.</p>
Disinfection of Alginate and Silicon Impressions by Using UV and Blue Light. (in Vivo Study)
Authors: AL-Yasiri Israa K. , Hamed Suhad Jabbar , AL- Khafagy Mohammad T. 
Published: April 2023

Background: There is growing concern about the issue of cross-infection in dental clinics and laboratories. There are many methods of disinfection for impression material; but these conventional strategies present several disadvantages. In this study we introduce the UV and blue light as effective savable method for the disinfection of the impression.
Objectives: The purpose of this study was to evaluate the disinfection potential of UV and blue light on alginate and silicon impression material.
Methodology: Forty college students were randomly selected in Collage of Dentistry / University of Kufa during the period between 1 December 2011 to 1 October 2011. And 40 alginate and silicon impressions were taken and grouped according to time of exposure (10 and 20 minutes). Each impression was cultured on blood agar and Mackonky agar before treatment with UV light or blue light, the treatment was done after 10 and 20 minutes; then cultured for bacterial inspection. The data were analyzed statistically using Chi-square test and P-value 0.05.
Result: The culture showed that all the silicone impressions gave a positive result after treatment with blue light and UV light except a group that treated with UV light for 20 minutes, which showed significant reduction in the bacterial growth. All the alginate impressions give positive culture after treatment with UV and blue light after 10 and 20 minutes.
Conclusion: in this study, we conclude that the silicon impression can be sterilized with UV light when treated for 20 minutes.