bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invasive beta-haemolytic streptococcal infections, Finland, 2006 to 2020: increase in Lancefield group C/G infections
Authors: Paspaliari Dafni Katerina , Sarvikivi Emmi , Ollgren Jukka , Vuopio Jaana 
Published: August 2023

Background
Invasive infections with beta-haemolytic streptococci of Lancefield groups A (iGAS), B (iGBS) and C/G (iGCGS) are a major cause of morbidity and mortality worldwide.

Aim
We studied incidence trends of invasive beta-haemolytic streptococcal infections in Finland, focusing on iGCGS.

Methods
We conducted a retrospective register-based study. Cases were defined as isolations from blood and/or cerebrospinal fluid and retrieved from the National Infectious Disease Register where all invasive cases are mandatorily notified.

Results
Between 2006 and 2020, the mean annual incidence was 4.1 per 100,000 for iGAS (range: 2.1–6.7), 5.2 for iGBS (4.0–6.3) and 10.1 for iGCGS (5.4–17.6). The incidence displayed an increasing trend for all groups, albeit for iGBS only for individuals 45 years and older. The increase was particularly sharp for iGCGS (8% annual relative increase). The incidence rate was higher in males for iGCGS (adjusted incidence rate ratio (IRR) = 1.6; 95% confidence interval (CI): 1.5–1.8) and iGAS (adjusted IRR = 1.3; 95% CI: 1.1–1.4); for iGBS, the association with sex was age-dependent. In adults, iGCGS incidence increased significantly with age. Recurrency was seen for iGCGS and secondarily iGBS, but not for iGAS. Infections with iGCGS and iGBS peaked in July and August.

Conclusions
The incidence of invasive beta-haemolytic streptococcal infections in Finland has been rising since 2006, especially for iGCGS and among the elderly population. However, national surveillance still focuses on iGAS and iGBS, and European Union-wide surveillance is lacking. We recommend that surveillance of iGCGS be enhanced, including systematic collection and typing of isolates, to guide infection prevention strategies.
Leuit and the Food Preservation System During the Pandemic as a Form of Local Wisdom of the Indigenous People of Kasepuhan Sinar Resmi Cisolok Sukabumi West Java
Authors: Firmansyah Eka Kurnia , Sunarni Nani , Maulia Lia 
Published: August 2023

This research discusses the system of food storage during the pandemic through rice storage in Leuit in the community of Kasepuhan Sinar Resmi Village, Cisolok District, Sukabumi Regency, also examines what tools, times and types are used to carry out the belief rituals they use in food storage, especially during the Seren Taun traditional ceremony.
This research discusses how the food storage system during the pandemic through rice storage in Leuit in the community of Kasepuhan Sinar Resmi Village, Cisolok District, Sukabumi Regency, also examines what tools, times and types are used to carry out the belief rituals they use in food storage, especially during the Seren Taun traditional ceremony.
The results of this research can be described as a stable food storage system for hundreds of years, namely from the time of the ancestors until now and it was found what moral values are contained in the implementation of religious rituals or beliefs that they believe in. Another benefit of this research is that the community and local governments are expected to be able to provide information input and become one of the reference discourses in the food preservation system and the preservation of the inventory of cultural heritage of the community, especially the Sundanese in the southern West Java region
Efektivitas Inquiry Learning Berbantuan Media Prize Draw Game terhadap Hasil Belajar Siswa
Authors: Hamidah Izzah Nor Cholisotul , Panduwinata Lifa Farida 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui efektivitas penerapan pembelajaran inkuiri learning berbantuan media prize draw game pada mata pelajaran OTK Kepegawaian terhadap hasil belajar siswa kelas XII OTKP SMKN 1 Lamongan. Penelitian ini ialah penelitian quasi eksperimen dengan desain posttest only control dengan nonequivalent grups. Populasi penelitian ini adalah siswa kelas XII Otomasi Tata Kelola Perkantoran Tahun Pelajaran 2022/2023 yang berjumlah 71 siswa. Teknik pengambilan sampel yang dipakai ialah purposive sampling. “Metode pengumpulan data menggunakan tes, observasi dan dokumentasi. Teknik analisis data yang digunakan adalah analisis deskriptif dan analisis statistik inferensial. Hasil penelitian menunjukkan bahwa hasil belajar siswa kelas eksperimen lebih tinggi dibandingkan kelas control” dan model inkuiri berbantuan dengan media permainan undian berhadiah tidak efektif berdasarkan nilai signifikansi uji-t > 0,05
DAMPAK PEMBANGUNAN SENTRA IKM MENGGUNAKAN DANA ALOKASI KHUSUS (DAK) TERHADAP BANYAKNYA INDUSTRI KECIL MENENGAH DI INDONESIA
Authors: Maharani Ellita Rahardyan , Riyanto Riyanto 
Published: August 2023

Pembangunan Sentra Industri Kecil Menengah (Sentra IKM) merupakan salah satu program kebijakan Pemerintah yang bertujuan untuk pengembangan dan penumbuhan Industri Kecil Menengah (IKM) baru serta untuk percepatan pemerataan pemerataan industri di seluruh Indonesia. Pembangunan Sentra IKM ini dilakukan menggunakan Dana Alokasi Khusus (DAK) Fisik. Penelitian ini bertujuan menganalisis dampak program pembangunan Sentra IKM tahun 2016-2019 terhadap peningkatan banyaknya Industri Kecil Menengah di Indonesia dengan menggunakan Data Industri Mikro Kecil, Data Industri Besar Sedang serta Data Status Operasional Sentra IKM dan menggunakan metode fixed effect difference in difference (FE-DID). Hasil penelitian ini menunjukkan bahwa operasional Sentra IKM di kabupaten/kota di Pulau Sulawesi, Jawa, Nusa Tenggara, Kalimantan, Maluku dan Papua memiliki dampak signifikan terhadap peningkatan banyaknya IKM pada jenis industri pangan, kerajinan dan alat angkut. Namun dampak tersebut berbeda pada jenis industri logam dan alat mesin pertanian di Pulau Jawa dan Sumatera akibat adanya perbedaan kondisi wilayah dan manfaat produktivitas pada masing-masing jenis industri. Hasil penelitian ini menunjukkan bahwa Program Pembangunan Sentra IKM efektif dalam menumbuhkan IKM baru di luar Pulau Jawa dan Sumatera pada jenis industri padat karya
Adsorptive removal of Cr (VI) from aqueous solution using laboratory prepared ZnO nanoparticles
Authors: Rajbhandari Nyachhyon Armila , Pote Shrestha Rojita 
Published: August 2023

Nano sized zinc oxide (ZnO) been successfully prepared in laboratory by precipitation technique. As prepared ZnO materials were characterized by XRD and SEM analyses. The XRD pattern showed the crystallinity of the material and average crystallite size was found to be 16.61 nm. The SEM images of ZnO nanoparticle revealed that it was flakes like structure having smooth texture. Batch adsorption experiments were performed to investigate the percentage removal of Cr (VI) from aqueous solution. The effects of Cr (VI) concentration, pH of solution, adsorbent dose and contact time variations were studied in order to have adsorptive efficiency of as prepared ZnO nanoparticles. The optimum contact time for maximum adsorption was found to be 90 minutes. The optimum pH was found to be 2.0 at an initial concentration of 20 mg/L. Similarly, the optimum dose of ZnO for the adsorption of Cr (VI) was found to be 0.4 g. The adsorption properties of ZnO were then evaluated by using Langmuir, Freundlich and Temkin isotherm models. The maximum adsorption capacity (Qm) was found to be 3.43 mg/g which is in good agreement with literature value. The correlation value showed that Langmuir isotherm model was found to be more favorable than Freundlich and Temkin adsorption isotherm model, indicating the presence of homogeneous equivalent active sites in ZnO with monolayer adsorption.
Water quality and health risk assessment in the Gandaki river basin, central Himalaya, Nepal
Authors: Pant Ramesh Raj , Pal Khadka Bahadur , Rehman Faizan Ur , Bishwakarma Kiran , Pathak Lalit , Thapa Lal Bahadur 
Published: August 2023

Public health is at threat due to chemical contaminants in drinking water which may have direct health concerns. The suitability of water for health is primarily governed by the mineral constituents present in the water. The present study was carried out to evaluate the water quality and associated health risks in the Gandaki River Basin (GRB) in Central Himalaya, Nepal considering hydrochemical variables such as total dissolved solids (TDS); major cations (Ca2+, Mg2+, K+, and Na+); major anions (Cl-, NO3-, SO42-, and HCO3-) and trace metals (As, Cu, Mn, Ni, Pb, Zn, Ba, Cr, Li and Sr) in spatiotemporal levels. Water Quality Index (WQI), Health Risk Assessment (HRA), and Cancer Index (CI) were analyzed to evaluate the overall quality of water in the GRB. The results revealed that all the examined variables were within the National Guidelines recommended for domestic uses. Moreover, the results revealed that concentrations of TDS, major ions, and trace metals showed significant seasonality and the WQI values were found to be 36.38, 23.77, and 30.36 in pre-monsoon, monsoon, and post-monsoon, respectively indicating better water quality in the monsoon season. Additionally, CI analysis of the selected trace metals such as As, Cr and Pb indicated relatively low cancer risk in the river water during all the seasons. The hazard quotient (HQ) dermal values of all the elements were < 1, signifying the little or no adverse effects via a dermal path, while HQ ingestion values of Ba, Li, Sr, and Zn were found to be >1 during all the seasons indicating their possible threat via ingestion path. This study provides a useful database and suggests regular assessment and, also appropriate policy formulations for safeguarding the water bodies in the Himalayas.
Evaluation of mesiobuccal root canal morphology and interorifice distance in maxillary first molar teeth: a CBCT study on Southeast Anatolian population
Authors: UYSAL İbrahim , KOÇ Nevzat 
Published: August 2023

Aims: The aim of this study was to evaluate the mesiobuccal root canal morphologies and interorifice distances of maxillary first molars using cone-beam computed tomography (CBCT).
Methods: CBCT images of 477 patients who had undergone CBCT for various reasons were examined and 654 maxillary first molars were included in the study according to the study criteria.
Results: The most common canal configuration observed in mesiobuccal roots was type II (p < 0.05). The median interorifice distance was 2.28 mm in roots with type II canal configuration, while it was measured as 2.55 mm in roots with type IV canals, and a significant difference was found depending on the presence of canal in the apical third of the root (p < 0.001). The median interorifice distance was found to be 2.58 mm in males and 2.34 mm in females, and a significant difference was detected (p < 0.001).
Conclusion: Various canal variations can be observed in the mesiobuccal roots of maxillary first molars, and the length of interorifice distance can predict the canal type. This information can increase the success rate of endodontic treatment.
Comparing modeling strategies combining changes in multiple serum tumor biomarkers for early prediction of immunotherapy non-response in non-small cell lung cancer
Authors: van Delft Frederik A. , Schuurbiers Milou M.F. , Muller Mirte , Burgers Sjaak A. , van Rossum Huub H. , IJzerman Maarten J. , van den Heuvel Michel M. , Koffijberg Hendrik 
Published: August 2023

BACKGROUND: Patients treated with immune checkpoint inhibitors (ICI) are at risk of adverse events (AEs) even though not all patients will benefit. Serum tumor markers (STMs) are known to reflect tumor activity and might therefore be useful to predict response, guide treatment decisions and thereby prevent AEs. OBJECTIVE: This study aims to compare a range of prediction methods to predict non-response using multiple sequentially measured STMs. METHODS: Nine prediction models were compared to predict treatment non-response at 6-months ( n = 412) using bi-weekly CYFRA, CEA, CA-125, NSE, and SCC measurements determined in the first 6-weeks of therapy. All methods were applied to six different biomarker combinations including two to five STMs. Model performance was assessed based on sensitivity, while model training aimed at 95% specificity to ensure a low false-positive rate. RESULTS: In the validation cohort, boosting provided the highest sensitivity at a fixed specificity across most STM combinations (12.9% –59.4%). Boosting applied to CYFRA and CEA achieved the highest sensitivity on the validation data while maintaining a specificity >95%. CONCLUSIONS: Non-response in NSCLC patients treated with ICIs can be predicted with a specificity >95% by combining multiple sequentially measured STMs in a prediction model. Clinical use is subject to further external validation.
Lack of clinical utility of serum macrophage migration inhibitory factor (MIF) for monitoring therapy response and estimating prognosis in advanced lung cancer
Authors: Rupp Alexander , Bahlmann Sophie , Trimpop Nicolai , von Pawel Joachim , Holdenrieder Stefan 
Published: August 2023

BACKGROUND: Lung cancer is a major burden to global health and is still among the most frequent and most lethal malignant diseases. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in a variety of processes including tumorigenesis, formation of a tumor microenvironment and metastasis. It is therefore a potential prognostic biomarker in malignant diseases. OBJECTIVE: In this study, we investigated the applicability of MIF in serum samples as a biomarker in lung cancer. METHODS: In a retrospective approach, we analyzed the sera of 79 patients with non-small-cell lung cancer (NSCLC) and 14 patients with small-cell lung cancer (SCLC) before the start of chemotherapy, as well as before the second and third chemotherapy cycle, respectively. Serum MIF levels were measured using a sandwich immunoassay with a sulfo-tag-labelled detection antibody, while pro-gastrin releasing peptide (proGRP) levels were determined with an enzyme-linked immunosorbent assay. RESULTS: No difference in serum MIF levels between responders and non-responders to chemotherapy was observed at all time points, while proGRP levels were significantly lower in responders before the second chemotherapy cycle ( p = 0.012). No differences in biomarker levels depending on the histopathological classification of NSCLC patients was found. Moreover, in ROC curve analyses MIF was not able to distinguish between responders and non-responders to therapy. proGRP could differentiate between responders and non-responders before the second chemotherapy cycle ( p = 0.015) with sensitivities of 43% at 90% and 95% specificity, respectively. Likewise, proGRP yielded significantly longer survival times of patients with low proGRP concentrations before the second chemotherapy cycle ( p = 0.015) in Kaplan-Meier analyses, yet MIF showed no significant differences in survival times at all time points. Comparison with the biomarkers CEA and CYFRA 21-1 in the same cohort showed that these established biomarkers clearly performed superior to MIF and proGRP. CONCLUSIONS: From the present results, there is no indication that serum MIF may serve as a biomarker in prognosis and monitoring of response to therapy in lung cancer. Limitations of this study include its retrospective design, the inclusion of a larger NSCLC and a smaller SCLC subgroup, the classical chemotherapeutic treatment, the use of a non-diagnostic immunoassay (RUO-test) for MIF measurement and the lack of a validation cohort. Strengths of the study are its highly standardized procedures concerning sample collection, preanalytic treatment, measurements and quality control of the laboratory assays.
Features of design and calculations of complex reinforced concrete frames of buildings
Authors: Ivanchenko Gryhoriy , Getun Galyna , Bezklubenko Iryna , Solomin Andriy 
Published: August 2023

The article considers and systematizes the load-bearing structural systems of buildings with complex space-planning configurations, taking into account design solutions, structural loading and stress states. The features of the perception of loads and their rational distribution between the structural elements of frame buildings with complex space-planning solutions are analyzed. The main structural schemes of complex frames, schemes of their deformations and plots of moments under the influence of vertical and horizontal loads are introduced. The paper reflects the modern practice of preliminary approximate calculations of the approximate dimensions of the sections of frame structures of frame buildings for the possibility of further collecting loads and performing refined calculations using modern calculation software systems.
The proposed method for modeling the nature of the work of complex frames of frame buildings and coordinating their space-planning, design and calculation systems will be useful for researchers, architects and design engineers during the design of new types of buildings, taking into account their operation under emergency conditions.
Comparative analysis of dynamic stability of cylindrical and conical shells under periodic axial compression
Authors: Palii Oksana , Lukianchenko Olga , Kozak Andriy 
Published: August 2023

A comparative analysis of the dynamic stability of cylindrical and conical shells with the same geometric and mechanical characteristics under periodic uniformly distributed axial compression was presented. The study of the stability of steady periodic vibrations of thin elastic shells was based on the joint use of the method of curvilinear grids, the projection method and the parameter continuation method combined with the Newton–Kantorovich method. Geometrically nonlinear relations of the thin elastic shells theory are formulated on the basis of the vector approximation of the displacements function in the general curvilinear coordinate system in tensor form and satisfy the Kirchhoff-Love hypothesis. The discretization of the differential equations of the steady forced vibrations in the direction of the generating shells using the method of curvilinear grids was carried out. The components of the elements displacement vectors of the shells middle surface in the circular directionare approximated by trigonometric series. Reduction of the number of generalized coordinates of the discrete dynamic model of shells steady forced vibrations was performed by the Bubnov-Galerkin basis reduction method. A transition from vector ordinary differential equations to a nonlinear system of algebraic equations was made. The construction of a mathematical model of the dynamic stability of steady forced nonlinear vibrations of thin elastic shells was performed according to Floquet's theory using the projection method. The criterion for the loss of stability was the equality to zero of the determinant of the matrix of linearized equations of steady forced nonlinear vibrations of shells according to the Lyapunov theorem. A comparative analysis of frequencies and modes of natural vibrations of cylindrical and conical shells with the same geometric and mechanical characteristics and boundary conditions was performed. Nonlinear steady vibrations of the shells due to periodic axial compression were studied. The critical values of the dynamic load and the corresponding forms of loss of shell stability in the range of lower frequencies of their natural vibrations were obtained.
Levels of Myostatin, Adiponectin and Lipid Profile in Hyperlipidemia Patients
Authors: Rashid Safa Mansor , Alabbasy Raghad Hazem , Abdul Wahed Aseel Mokdad Hatam 
Published: August 2023

Background: Excess fat is one of the biggest risk factors for the development of heart disease and one of the top five leading causes of death. The researchers expect from their study that deaths due to cardiovascular diseases will increase from (17.3) million cases in 2017 to (23.6) million deaths by 2030.
Aim: Determination of the concentration of lipid profile variables (TC, TG, HDL-C, LDL-C, VLDL-C). Estimating the concentration of some hormones such as myostatin and adiponectin in the serum of study samples in males and females with hyperlipidemia at different ages.
Materials and methods: The study included collecting (90) samples and dividing them into two groups (20-60).Blood samples were collected from the vein (10ml) using medical syringes, and the blood was placed in plastic tubes, where the samples were left for (15-20) minutes at a temperature of 37 °C in a water bath until the blood coagulated, and then the samples were separated in a centrifuge.
Results: the results showed a significant increase in each of TC, TG, LDL and VLDL, and a significant decrease in Myostatin and HDL, while the results showed no significant difference in Adiponectin. In females compared to healthy subjects the results showed a significant increase in TC, TG, LDL, and VLDL, and the results showed a significant decrease in HDL, while the results showed that there was no significant difference in both Adiponectin and Myostatin.
Conclusions: We conclude from our current study that hyperlipidemia is associated with an imbalance in the level of muscular lipid movements and is therefore considered a risk factor for the occurrence of cardiovascular diseases and requires follow-up and a healthy diet with treatment.
Adropin, Insulin, Insulin Resistance and Lipid Profile Levels in Diabetes Mellitus Type2 Patients
Authors: Ahmed Elaf Husham , Hatam Aseel Mokdad 
Published: August 2023

Background: Type 2 diabetes mellitus (T2DM) is non-insulin-dependent diabetes or diabetes that affects adults, and it represents 90% of diabetics and it occurs as a result of insulin resistance and a defect in insulin production. We aimed to evaluate levels of adropin, insulin, insulin resistance and lipid profile levels in diabetes mellitus type2 patients.
Aim: The current study aimed to investigate the relationship between type 2 diabetes mellitus and liver and adipose tissue by measuring the level of secreted Hepatokines and a number of hormonal and biochemical parameters in men.
Materials and Methods: The study group include 60 men with type 2 diabetes mellitus and a control group of 30 healthy men. Proteins and biochemistry assays include Adropin levels, insulin, Fasting blood sugar, Insulin resistance indicators(HOMA-IR,HOMA-B,QUICKI),Total cholesterol, Triglycerides, High-density lipoprotein for cholesterol, Low-density lipoprotein for cholesterol, Very high-density lipoprotein for cholesterol, Phospholipid and Atherogenic index.
Results: There was a significant increase at (P≥0.05) in Adropin levels, Fasting blood sugar, Total cholesterol, triglycerides, High-density lipoprotein for cholesterol, Low-density lipoprotein for cholesterol, Very high-density lipoprotein for cholesteroland Phospholipid in type 2 diabetes mellitus men compared to control group. while insulin and HOMA-B show significant decrease at (P≥0.05) in type 2 diabetes mellitus men compared to control group. Atherogenic index, HOMA-IR and QUICKI didn’t show any significant difference between both groups.
Conclusions: We conclude from the results of the current study that there is a relationship between type 2 diabetes mellitus and liver dysfunctions through a secretion imbalance of Adropin that indicates an association between liver disease and type 2 diabetes mellitus. The metabolic imbalances or risks of insulin resistance can lead to hyperglycemia, dyslipidemia, and obesity.