bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computed tomography in the assessment of aneurysmal subarachnoid hemorrhage for functional outcome and delayed cerebral ischemia: a retrospective cohort study.
Authors: David Couret , Boussen Salah , Cardoso Dan , Alonzo Audrey , Madec Sylvain , Reyre Anthony , Brunel Hervé , Girard Nadine , Graillon Thomas , Dufour Henry , Bruder Nicolas , Boucekine Mohamed , Meilhac Olivier , Simeone Pierre , Velly Lionel 
Published: March 2023

Abstract
BACKGROUND/OBJECTIVE

Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening event with major complications such as delayed cerebral ischemia (DCI) or acute hydrocephalus and poor neurological outcome. DCI occurs most frequently 7 days after aSAH and can last for a prolonged period. The ability to predict these complications would allow the neuro-intensivist to identify patients at risk and select the most appropriate unit for hospitalization. To determine the most predictive radiological scales in grading subarachnoid or ventricular hemorrhage or both for functional outcome at 3 months in a large aSAH population, we conducted a single centre retrospective study in a neurocritical care unit.

METHODS

A 3-year single-centre retrospective cohort study of 230 patients hospitalized for aSAH was analysed. Initial computed tomography (CT) scans in patients hospitalized for aSAH were blindly assessed using eight grading systems: the Fisher grade, modified Fisher grade, Barrow Neurological Institute scale, Hijdra scale, Intraventricular Hemorrhage (IVH) score, Graeb score, and LeRoux score. We evaluated and compared these radiological scales for the early prediction of DCI, acute hydrocephalus, and poor neurological outcome at 3 months.

RESULTS

Of 200 patients with aSAH who survived to day 7 and were included for DCI analysis, 39% cases were complicated with DCI. The Hijdra scale was the best predictor for DCI, with a receiver operating characteristic area under the curve (ROCAUC) of 0.80 (95% confidence interval [CI], 0.74–0.85) compared to other scales (Fisher grade 0.52 (95% CI, 0.47–0.59) modified Fisher grade: 0.67 (95% CI, 0.60–0.73); Claassen Scale: 0.66 (95% CI, 0.59–0.72) and BNI Scale: 0.63 (95% CI, 0.56–0.70)). The IVH score was the most effective grading system for predicting acute hydrocephalus, with a ROCAUC of 0.85 (95% CI, 0.79–0.89). In multivariate analysis, the Hijdra scale was the best predictor of the occurrence of DCI (hazard ratio, 1.18; 95% CI, 1.10–1.25).

CONCLUSIONS

Although these results have yet to be prospectively confirmed, our findings suggest that the Hijdra scale may be a good predictor of DCI and could be useful in daily clinical practice.
Enyne acetogenins from Porcelia macrocarpa fruit peels displayed anti-Trypanosoma cruzi activity in vitro and cause a reduction in the intracellular calcium level in the parasites
Authors: Thevenard Fernanda , Brito Ivanildo , Costa-Silva Thais , Tempone Andre , Lago Joao Henrique 
Published: March 2023

Abstract
Natural products are a promising source of new compounds with a wide spectrum of pharmacological properties, including antiprotozoal activities. Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is one of several neglected tropical diseases with reduced options for treatment, which presents limitations such as toxicity and ineffectiveness in the chronic stage of the disease. Aiming to investigate the Brazilian flora for the discovery of new anti-T. cruzi compounds, the MeOH extract from Porcelia macrocarpa R.E. Fries (Annonaceae) fruit peels displayed potent activity against trypomastigotes and intracellular amastigotes and was subjected to bioactivity-guided fractionation. Using different chromatographic steps, it was obtained a fraction composed of a mixture of four new chemically related acetogenins which were characterized as (2S*,3R*,4R*)-3-hydroxy-4-methyl-2-(n-octadeca-13’,17’-dien-11’-inil)butanolide (1), (2S*,3R*,4R*)-3-hydroxy-4-methyl-2-(n-eicosa-13’,19’-dien-11’-inil)butanolide (2), (2S*,3R*,4R*)-3-hydroxy-4-methyl-2-(n-octadec-13’-en-11’-inil)butanolide (3), and (2S*,3R*,4R*)-3-hydroxy-4-methyl-2-(n-eicosa-13’-en-11’-inil)butanolide (4) by analysis of NMR and UHPLC/ESI-HRMS data. The fraction composed of the mixture of compounds 1–4, displayed an EC50 of 4.9 and 2.5 mg/mL against trypomastigote and amastigote forms of T. cruzi, respectively, similar to standard drug benznidazole (EC50 of 4.8 and 1.4 mg/mL). Additionally, the fraction composed of 1–4 displayed no mammalian toxicity for murine fibroblasts (CC50 > 200 mg/mL), resulting in a SI > 40.8 and > 83.3 against trypomastigotes and amastigotes, respectively. Based on these results, the mechanism of action of this fraction was investigated. After a short-time incubation with the trypomastigotes, no alterations in the cell membrane permeability were observed. However, it was verified a decrease in the intracellular calcium of the parasites, without significant pH variations of the acidocalcisomes. The intracellular damages were followed by an upregulation of the reactive oxygen species (ROS) and ATP, but no depolarization effects were observed in the mitochondrial membrane potential. These data suggest that the fraction composed of 1–4 caused an irreversible oxidative stress in the parasites, leading to death. If adequately studied, these acetogenins can open new insights for discovery of new routes of death in T. cruzi.
Predictors for Invasive Therapy in the Management of Crohn’s Disease-related Spontaneous Intra-abdominal Abscess: Prognosis and Long-term Follow-up
Authors: Sun Yinghao , Liu Wei , Ma Ye , Yang Hong , Li Yue , Tan Bei , Li Ji , Qian Jiaming 
Published: March 2023

Abstract
Background
Decision-making in the management of Crohn’s disease (CD)-related spontaneous intra-abdominal abscess (IAA) is challenging. This study aims to reveal predictive factors for percutaneous drainage and/or surgery in the treatment of CD-related spontaneous IAA through long-term follow-up.
Methods
Data were collected, including clinical manifestations, radiography and treatment strategies, in Chinese patients with CD-related IAA in a tertiary medical center from Jan 2014 to Dec 2017. A Cox proportional hazards regression model was used to identify predictors for invasive therapy, which were incorporated together to develop a prognostic nomogram. Validation of the nomogram was assessed by a separate cohort of patients with CD-related IAA from Jan 2018 to Mar 2021.
Results
Altogether, 33 CD patients were identified as having IAA through enhanced CT scans. The median follow-up time was 52.0 (33.5, 60.0) months. Eighteen (54.5%) patients underwent conservative medical treatment, and 15 (45.5%) patients underwent percutaneous drainage and/or surgical intervention (invasive treatment group). The 1-, 2-, and 5-year overall survival rates without invasive treatment were 69.7%, 57.3%, and 53.7%, respectively. On univariate Cox analysis, nonperienteric abscess (HR: 6.391, 95% CI: 1.970-20.728, p = 0.002), max abscess diameter (HR: 1.015, 95% CI: 1.005–1.025, p = 0.003) and width of sinus (HR: 1.246, 95% CI: 1.037–1.498, p = 0.019) were significantly associated with worse OS without invasive treatment. Nonperienteric abscess was significantly associated with worse OS without invasive treatment on multivariate Cox analysis (HR: 5.738, 95% CI: 1.763–18.672, p = 0.004). These factors were incorporated together to develop a prognostic nomogram and were externally confirmed in the validation cohort. The concordance index was 0.842 (95% CI: 0.681–0.983, p < 0.001).
Conclusions
Nonperienteric abscesses indicate a more aggressive treatment strategy, such as percutaneous drainage and/or surgery, in the management of CD-related IAA. A nomogram could help recognize patients who are more likely to require invasive treatment.
Impacts of obesity and metabolic health on global subclinical left cardiac function: TyG index may be a predictor
Authors: Mei Jiajie , Li Yanhua , Dong Jianli , Bai MiaoMiao , Jiang Yinong , Qu Xiaofeng , Yin Lili 
Published: March 2023

Abstract
Background: Obesity is a recognized risk factor for heart failure. People with similar weights may have different metabolic health. Notably, insulin resistance is a hallmark of obesity and a feature of heart failure. We aimed to evaluate the effects of obesity and metabolic health status on subclinical left cardiac function. We also investigated whether insulin resistance (TyG index) plays a role in BMI-linked subclinical left cardiac dysfunction.
Methods: The study involved 403 volunteers. Multivariate logistic regression models were used to assess associations between obesity, metabolic health, and overall subclinical left cardiac function .Mediating analysis was used to explore the role of the TyG index in the association between BMI and left cardiac function. Finally, ROC analysis was performed to explore the predictive value of the TyG index in subclinical left cardiac dysfunction.
Results: The correlation analysis showed that metabolic unhealth increased the risk of subclinical left ventricular (LV) dysfunction; obesity was associated with an increased risk of global left cardiac dysfunction regardless of metabolic health status. The TyG index mediated 25% of the associations between BMI and Left atrial (LA) function. ROC analysis exhibited that the TyG index can be used as a predictor of LA dysfunction (AUC = 0.63), and the optimal cut-off point for the TyG index is 9.33.
Conclusions: Even a "non-obese metabolically unhealthy" is a detrimental state of early LV function; obesity remains a major risk factor for global subclinical left cardiac dysfunction. Using the TyG index could allow early identification of individuals at high risk of subclinical left cardiac dysfunction.
Registration number：ChiCTR2200057991；Date of registration: 2022-03-25
URL:http://www.chictr.org.cn/showproj.aspx?proj=162316
All together now: disentangling Beatles’ song titles in medical research articles
Authors: Maci Stefania , Lorenzo Cherubino Di , Vollono Catello 
Published: March 2023

Abstract
Background
The purpose of this paper is to understand the reason(s) why Beatles’ song titles are used as titles for medical research publications.
Methods
546 article titles have been collected over a period of 57 years (1965–2022) and linguistically analysed. Titles were classified according to three different perspectives: (1) a textual perspective (level of informativeness); (2) a sentence viewpoint (information packaging and meaning); and at (3) the lexical level (degree of accessibility and referential transparency).
Result
Here we show that the Beatles' quotations have gradually augmented over the years, with a peak in 2002, and then a gradual rise up to 2021, with a preference for using compound (57.32%) and nominal (38.09%) titles. As to the way in which information is packaged, titles are primarily focus ones (62.08). Interestingly, well 75.64% titles are constructed with no specialized language, while only 5.86% titles are ‘language as mention’, that is titles with markedly non-specialized items which appear to be borrowed from the song itself and stylistically marked with the actual quotations
Conclusions
Our findings suggest that, by quoting a Beatles song title, the author of the publication clearly creates an attention-seeking device with startling effect. Such an approach does not appear to be dependent on a specific period of time, journal, or Beatles song. They can thus be defined as attractors.
Germline pathogenic variants in HNRNPU are associated with alterations in blood methylome
Authors: Balasubramanian Meena , Lee Sunwoo , Ochoa Eguzkine , Badura-Stronka Magdalena , Donnelly Deirdre , Lederer Damien , Lynch Sally , Gardham Alice , Morton Jenny , Stewart Helen , Docquier France , Rodger Fay , Martin Jose , Toribio Ana , Maher Eamonn , Balasubramanian Meena 
Published: March 2023

Abstract
HNRNPU encodes a multifunctional RNA-binding protein that plays critical roles in regulating pre-mRNA splicing, mRNA stability, and translation. Aberrant expression and dysregulation of HNRNPU have been implicated in various human diseases, including cancers and neurological disorders. We applied a next generation sequencing based assay (EPIC-NGS) to investigate genome-wide methylation profiling for > 2M CpGs for 7 individuals with a neurodevelopmental disorder associated with HNRNPU germline pathogenic loss-of-function variants. Compared to healthy individuals, 227 HNRNPU-associated differentially methylated positions were detected. Both hyper- and hypomethylation alterations were identified but the former predominated. The identification of a methylation episignature for HNRNPU-associated neurodevelopmental disorder (NDD) implicates HNPRNPU-related chromatin alterations in the aetiopathogenesis of this disorder and suggests that episignature profiling should have clinical utility as a predictor for the pathogenicity of HNRNPU variants of uncertain significance. The detection of a methylation episignaure for HNRNPU-associated NDD is consistent with a recent report of a methylation episignature for HNRNPK-associated NDD.
Application of artificial intelligence wearable devices based on neural network algorithm in mass sports activity evaluation
Authors: Liang Jun , He Qing 
Published: March 2023

Abstract
Based on the rapid development of big data, cloud computing, Internet of things and other technologies in recent years, intelligent hardware devices has been applied to all aspects of life. Under this background, some scholars have put forward relevant concepts such as "Smart Life". In the field of mass sports life, through the development and application of science and technology, there has been new changes related to the application of neural network algorithm technology and intelligent hardware devices. Therefore, artificial intelligence wearable devices based on wearable technology came into being. This paper analyzes the application of this device in mass sports activities. Then, this paper describes the key research technologies of motion data processing based on neural network algorithm, including: depth frame differential convolution neural network structure, motion data extraction method, human motion signal processing algorithm, etc; Then it analyzes the action recognition and interaction system design based on Intelligent wearable devices. Finally, it analyzes the recognition results of human action system, the accuracy of human action recognition system and the factors that affect the performance of the recognition system. It is concluded that the artificial intelligent wearable devices designed in this paper can be well used in popular sports activities. Finally, it introduces the research on the evaluation strategy of popular sports activities based on artificial intelligence, and hopes that this equipment can help public sports activities. This paper studies the neural network algorithm and applies it to the design process of artificial intelligence wearable devices, which promotes the development of mass sports activity evaluation.
Fractal Analysis of Mandibular Trabecular Structure in Individuals with Different Vertical Dentofacial Skeletal Patterns
Authors: Büyükbayraktar Zeynep Çoban , Büyük Süleyman Kutalmış , Korkmaz Yasemin Nur , Akdemir Hale 
Published: March 2023

Abstract
Background: Different vertical dentofacial skeletal patterns may affect bone density of the temporomandibular joint (TMJ) and various mandibular structures. This study aimed to examine changes in mandibular trabecular structure in vertical dentofacial patterns using fractal analysis.
Methods: Dental-skeletal Class I patients randomly selected from the university orthodontic clinic were allocated into 3 groups (low angle, normal angle and high angle) according to the SN-GoMe angle. Bone density of mandibular structures (corpus, angulus and condyle) were measured bilaterally on panoramic radiographs of the patients using fractal analysis.
Results: Left condylar fractal dimension (FD) measurements differed significantly among the groups (p=.041). Compared to other groups, left condylar FD values were lower in the high angle group. Right and left mandibular angulus FD values were lower in the low angle group but the difference was non-significant (p>.05). Within-group comparisons showed a significant difference in FD values between right and left corpus in the low angle subjects (p=.047).
Conclusion: Lower mandibular condylar FD values observed in high angle subjects may herald possible joint disorders. Low angle subjects exhibit lower FD values in the mandibular angulus. This may be related to degenerative changes in that region characterized by reduced bone density which results from increased muscle activity.
Complex Network Analysis of Back Squats Pre-Activation on Parameters of a 3-minute All-out Test in Recreational Runners
Authors: Gama Maria Carolina Traina , Manchado-Gobatto Fúlvia Barros , Gobatto Claudio Alexandre 
Published: March 2023

Abstract
This study aimed to investigate the impact of post-activation potentiation enhancement (PAPE) on parameters of 3-minute all-out test (3MT) on non-motorized tethered running performance by applying the concept of complex networks for integrative analysis. Ten recreational sports athletes where submitted to anthropometric tests, 1RM ramp, and 3MT trials (PAPE and CONTROL conditions) across five separate test sessions. The conditioning activity model applied was two series of six back squats at 60% 1RM. Based on the complex network, graphs were constructed for each scenario (CONTROL and PAPE) to investigate the Degree, Eigenvector, Pagerank, and Betweenness centrality metrics. PAPE scenario shows greater centrality of anthropometrics and conditioning parameters related to aerobic efficiency, ranking among the top-five classified nodes. Paired Student t-test (p ≤ 0.05) results for 3MT showed differences between two conditions (PAPE vs. CONTROL) for values of EP-W (407.83 ± 119.30; 539.33 ± 177.10) and rEP-W.kg-1(5.38 ± 1.70; 6.91 ± 2.00), and mechanical parameters in absolute and relativized values of peak output power, mean output power, peak force, and mean force. Our results suggest that PAPE modifies the graphs' configuration, raising the network density, and may increase the neuromuscular functions and running economy. In addition, it seems to optimize the activation of aerobic and anaerobic metabolism.
Acute bilateral deafness and bilateral blindness in a patient with liver cirrhosis
Authors: Xu Junrong , Li Fei , Xue Yongjie 
Published: March 2023

Abstract
Background

Wernicke encephalopathy (WE) is a devastating acute or subacute neurological disorder caused by thiamine deficiency. Wernicke encephalopathy is characterized by the triad of ocular signs, cerebellar dysfunction, and confusion. Visual loss and hearing loss are less common findings in WE. Here, we report a case of Wernicke encephalopathy in a nonalcoholic liver cirrhosis patient who present with acute bilateral deafness and bilateral blindness.

Case presentation

A 60-year-old Chinese man presented with a history of bilateral blindness and bilateral hypoacousia for 3 days. He had a history of liver cirrhosis, chronic hepatitis C virus infection and did not have a habit of alcohol consumption. Ophthalmologic and otologic examination showed no obvious abnormalities. MRI findings revealed symmetric FLAIR hyperintensities in the brain stem, medulla oblongata, bilateral dorsal thalamus, and periventricular region of the third ventricle. One day after hospitalization, the patient developed mild coma. Based on the laboratory and neuroimaging findings, we diagnosed the patient with Wernicke encephalopathy. He soon regained consciousness after administration of thiamine. Both visual acuity and hearing function improved gradually.

Conclusions

We suggest that Wernicke encephalopathy can present with bilateral blindness and bilateral deafness.
Blue mussels’ valve behavior exhibits daily and lunar rhythms during the high Arctic polar day
Authors: Moal Alexandre Le , Payton Laura , Andrade Hector , Camus Lionel , Ballantine Carl , Ciret Pierre , Tran Damien 
Published: March 2023

Abstract
Marine species exhibit a multitude of biological rhythms, in accordance with their complex ecosystem governed by sun, earth and moon trajectories. Because of the inclination of the earth’s axis, the high Arctic ecosystem is characterized by several months of permanent illumination during the polar day (PD). The persistence of biological rhythms in this photic context remains unclear. Yet, this information is crucial for the understanding of polar ecosystems functioning, as well as to predict the impact of future climate changes. Particularly, the impact of extreme photoperiods on recent invasive species remains largely unknown. Here, we investigate how environmental cycles shape the behavior of a re-emerging polar resident, the mussel Mytilus sp. during PD (17 April to 26 August 2020; Svalbard, Ny-Ålesund, 78°56’ N, 11°56’ E). Our results show that in the high Arctic PD, mussels’ behavior is shaped by both the photoperiod and the diel sun trajectories above the horizon. Additionally, mussels also exhibit tidal, semi-lunar, and lunar rhythms of valve opening amplitude. We argue that these rhythms may have ecosystems functioning implications, and that the mussels’ ability to deal with drastic light regimes may explain their northward expansion and new resettlement in high Arctic.
Introduction of 3D-classification and its derived surgical sequence of Schatzker type IV tibial plateau fractures
Authors: Liu Zihao , Wang Shengjie , Wang Shuai , Peng AQin 
Published: March 2023

Abstract
Introduction
Schatzker IV tibial plateau fractures usually have worse prognosis due to its high variability and the combination of bony and soft tissue injuries. The aim of this study was to introduce a new classification of Schatzker IV tibial plateau fractures based on the injury mechanism and evaluate its reliability. The secondary aim was to evaluate the outcomes of operative Schatzker IV tibial plateau fractures treated according to the surgical sequences which were determined by the new classification.
Materials and Methods
63 operative Schatzker IV tibial plateau fractures which were treated following the new surgical sequence were enrolled in our study. CT images of these patients were reviewed and classified twice according to our new classification by four observers. The reliability of the classification was calculated by application of kappa analysis. The surgical sequence determined by the classification was evaluated by observing the the postoperative efficacy during the follow-up.
Results
The intra-observer reliability of 3D-classification showed excellent agreement according to Landis and Koch (The mean k = 0.897, CI 0.806–0.971). And the inter-obsever reliability of 3D-classification also showed excellent agreement. (The mean k = 0.883, CI 0.786–0.961). All patients were followed up and the average follow-up of the cases was 12.8 months (6–28 months). As for the evaluation of the postoperative efficacy, according to KSS, 53 cases were rated as excellent, 8 cases were rated as good and 2 cases were considered as fair results.
Conclusions
The new proposed classification showed high intra and inter-observer reliability in our study. And the surgical sequence determined by the classification can help surgeons to acquire good reduction and rigid internal fixation. Therefore the new classification of Schatzker IV tibial plateau fractures and the accompanied surgical sequence are worthy of further popularization and application in clinical trials.