bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review and meta-analysis of cold exposure and cardiovascular disease outcomes
Authors: Fan Jie-Fu , Xiao Yu-Chen , Feng Yi-Fei , Niu Lu-Yu , Tan Xing , Sun Jia-Cen , Leng Yue-Qi , Li Wan-Yang , Wang Wei-Zhong , Wang Yang-Kai 
Published: March 2023

BackgroundCold exposure has been considered an essential risk factor for the global disease burden, while its role in cardiovascular diseases is still underappreciated. The increase in frequency and duration of extreme cold weather events like cold spells makes it an urgent task to evaluate the effects of ambient cold on different types of cardiovascular disease and to understand the factors contributing to the population's vulnerability.MethodsIn the present systematic review and meta-analysis, we searched PubMed, Scopus, and Cochrane. We included original research that explored the association between cold exposure (low temperature and cold spell) and cardiovascular disease outcomes (mortality and morbidity). We did a random-effects meta-analysis to pool the relative risk (RR) of the association between a 1°C decrease in temperature or cold spells and cardiovascular disease outcomes.ResultsIn total, we included 159 studies in the meta-analysis. As a result, every 1°C decrease in temperature increased cardiovascular disease-related mortality by 1.6% (RR 1.016; [95% CI 1.015–1.018]) and morbidity by 1.2% (RR 1.012; [95% CI 1.010–1.014]). The most pronounced effects of low temperatures were observed in the mortality of coronary heart disease (RR 1.015; [95% CI 1.011–1.019]) and the morbidity of aortic aneurysm and dissection (RR 1.026; [95% CI 1.021–1.031]), while the effects were not significant in hypertensive disease outcomes. Notably, we identified climate zone, country income level and age as crucial influential factors in the impact of ambient cold exposure on cardiovascular disease. Moreover, the impact of cold spells on cardiovascular disease outcomes is significant, which increased mortality by 32.4% (RR 1.324; [95% CI 1.2341.421]) and morbidity by 13.8% (RR 1.138; [95% CI 1.015–1.276]).ConclusionCold exposure could be a critical risk factor for cardiovascular diseases, and the cold effect varies between disease types and climate zones.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier: CRD42022347247.
Amplified sinus-P-wave analysis predicts outcomes of cryoballoon ablation in patients with persistent and long-standing persistent atrial fibrillation: A multicentre study
Authors: Creta Antonio , Venier Sandrine , Tampakis Konstantinos , Providencia Rui , Sunny Juno , Defaye Pascal , Earley Mark J. , Finlay Malcolm , Hunter Ross J. , Lambiase Pier D. , Papageorgiou Nikolaos , Schilling Richard J. , Sporton Simon , Andrikopoulos George , Deschamps Elodie , Albenque Jean-Paul , Cardin Christèle , Combes Nicolas , Combes Stéphane , Vinolas Xavier , Moreno-Weidmann Zoraida , Huang Taiyuan , Eichenlaub Martin , Müller-Edenborn Björn , Arentz Thomas , Jadidi Amir S. , Boveda Serge 
Published: March 2023

IntroductionOutcomes of catheter ablation for non-paroxysmal atrial fibrillation (AF) remain suboptimal. Non-invasive stratification of patients based on the presence of atrial cardiomyopathy (ACM) could allow to identify the best responders to pulmonary vein isolation (PVI).MethodsObservational multicentre retrospective study in patients undergoing cryoballoon-PVI for non-paroxysmal AF. The duration of amplified P-wave (APW) was measured from a digitally recorded 12-lead electrocardiogram during the procedure. If patients were in AF, direct-current cardioversion was performed to allow APW measurement in sinus rhythm. An APW cut-off of 150 ms was used to identify patients with significant ACM. We assessed freedom from arrhythmia recurrence at long-term follow-up in patients with APW ≥ 150 ms vs. APW &lt; 150 ms.ResultsWe included 295 patients (mean age 62.3 ± 10.6), of whom 193 (65.4%) suffered from persistent AF and the remaining 102 (34.6%) from long-standing persistent AF. One-hundred-forty-two patients (50.2%) experienced arrhythmia recurrence during a mean follow-up of 793 ± 604 days. Patients with APW ≥ 150 ms had a significantly higher recurrence rate post ablation compared to those with APW &lt; 150 ms (57.0% vs. 41.6%; log-rank p &lt; 0.001). On a multivariable Cox-regression analysis, APW≥150 ms was the only independent predictor of arrhythmia recurrence post ablation (HR 2.03 CI95% 1.28–3.21; p = 0.002).ConclusionAPW duration predicts arrhythmia recurrence post cryoballoon-PVI in persistent and long-standing persistent AF. An APW cut-off of 150 ms allows to identify patients with significant ACM who have worse outcomes post PVI. Analysis of APW represents an easy, non-invasive and highly reproducible diagnostic tool which allows to identify patients who are the most likely to benefit from PVI-only approach.
Comparison of biochemical markers and technetium 99m methoxyisobutylisonitrile imaging in primary and secondary hyperparathyroidism
Authors: Wang Yuhua , Liu Ye , Li Na , Zhang Wanchun 
Published: March 2023

ObjectiveTo investigate the differences in biochemical marker levels and the extent of lesion visualization on technetium 99m methoxyisobutylisonitrile (99mTc-MIBI) imaging between primary hyperparathyroidism (PHPT) and secondary hyperparathyroidism (SHPT).MethodsNineteen patients with PHPT and 14 patients with SHPT were enrolled in the study, all of whom underwent routine 99mTc-MIBI dual-phase planar imaging, single-photon emission computed tomography combined with computed tomography (SPECT/CT fusion) imaging, and serum biochemical and hormonal investigations prior to surgery. The target-to-non-target (T/NT) ratios were calculated based on images from the early and delayed phases of 99mTc-MIBI planar imaging and also based on SPECT/CT fusion imaging. The volume of the parathyroid glands was measured following their excision.ResultsA total of 62 parathyroid glands were removed: 14 parathyroid adenomas and five parathyroid carcinomas in PHPT patients; and 18 parathyroid adenomas, 17 parathyroid hyperplasia lesions, and eight instances of nodular hyperplasia with adenoma in SHPT patients. The median volume of the lesions in PHPT and SHPT was 1.69 cm3 and 0.52 cm3 respectively, and the difference between them was statistically significant (P = 0.001). The median T/NT ratios calculated at the early phase of 99mTc-MIBI planar imaging, the delayed phase of 99mTc-MIBI planar imaging, and the subsequent SPECT/CT fusion imaging were 1.51, 1.34, and 2.75, respectively, in PHPT, and 1.46, 1.30, and 1.38, in SHPT, respectively. The T/NT ratio difference between PHPT and SHPT on the SPECT/CT fusion imaging was statistically significant (P = 0.002). The histopathology subtypes of the lesions were associated with significant differences in two areas: the T/NT ratios on the SPECT/CT fusion imaging and the volume of the lesions (P=0.002, P&lt;0.001).ConclusionThe proportion of positive findings on 99mTc-MIBI dual-phase planar imaging and the T/NT ratios of 99mTc-MIBI SPECT/CT fusion imaging were higher in PHPT than in SHPT. The volume of parathyroid lesions in SHPT was smaller than in PHPT.
Role of increased neutrophil extracellular trap formation on acute kidney injury in COVID-19 patients
Authors: Kim In Soo , Kim Do Hyun , Lee Hoi Woul , Kim Sung Gyun , Kim Yong Kyun , Kim Jwa-Kyung 
Published: March 2023

BackgroundA strong association between elevated neutrophil extracellular trap (NET) levels and poor clinical outcomes in patients with coronavirus infection 2019 (COVID-19) has been reported. However, while acute kidney injury (AKI) is a common complication of COVID-19, the role of NETs in COVID-19-associated AKI is unclear. We investigated the association between elevated NETs and AKI and the prognostic role of NETs in COVID-19 patients.MethodsTwo representative markers of NETs, circulating nucleosomes and myeloperoxidase-DNA, were measured in 115 hospitalized patients. Serum levels of interleukin [IL]-6, monocyte chemotactic protein-1 [MCP-1], plasma von Willebrand factor (vWF) and urinary biomarkers of renal tubular damage (β2-microglobulin [β2M] and kidney injury molecule 1 [KIM-1]) were measured.ResultsAKI was found in 43 patients (37.4%), and pre-existing chronic kidney disease (CKD) was a strong risk factor for AKI. Higher circulating NET levels were a significant predictor of increased risk of initial ICU admission, in-hospital mortality (adjusted HR 3.21, 95% CI 1.08–9.19) and AKI (OR 3.67, 95% CI 1.30-10.41), independent of age, diabetes, pre-existing CKD and IL-6 levels. There were strong correlations between circulating nucleosome levels and urinary KIM-1/creatinine (r=0.368, p=0.001) and β2M (r=0.218, p=0.049) levels. NETs were also strongly closely associated with serum vWF (r = 0.356, p&lt;0.001), but not with IL-6 or MCP-1 levels.ConclusionsElevated NETs were closely associated with AKI, which was a strong predictor of mortality. The close association between NETs and vWF may suggest a role for NETs in COVID-19-associated vasculopathy leading to AKI.
Providing person-centered palliative care in conflict-affected populations in the Middle East: What matters to patients with advanced cancer and families including refugees?
Authors: Guo Ping , Alajarmeh Sawsan , Alarjeh Ghadeer , Alrjoub Waleed , Al-Essa Ayman , Abusalem Lana , Giusti Alessandra , Mansour Asem H. , Sullivan Richard , Shamieh Omar , Harding Richard 
Published: March 2023

IntroductionUniversal health coverage highlights palliative care as an essential component of health services. However, it is unclear what constitutes person-centered care in populations affected by conflict, as they may have specific concerns in the dimensions of physical, emotional, social, and spiritual wellbeing. This study aimed to identify what matters to patients with advanced cancer and family caregivers in Jordan including refugees, to inform appropriate person-centered assessment and palliative care in conflict-affected populations.MethodsCross-sectional face-to-face, semi-structured interviews were conducted at two sites in Amman. Adult patients with advanced cancer and family caregivers were purposively sampled to maximize diversity and representation. Interviews were digitally audio recorded, anonymized, and transcribed verbatim for thematic analysis.FindingsFour themes were generated from 50 patients (22 refugees; 28 Jordanians) and 20 caregivers (7 refugees; 13 Jordanians) (1). Information, communication, and decision-making. Truth-telling and full disclosure from clinicians was valued, and participants expressed concerns that information was not shared in case patients would disengage with treatment. (2) Priorities and concerns for care and support. Participants’ top priority remained cure and recovery (which was viewed as possible). Other priorities included returning to their “normal” life and their “own” country, and to continue contributing to their family. (3) Role of spirituality and Islam. Most participants had strong faith in God and felt that having faith could comfort them. For refugees whose social network was fractured due to being away from home country, prayer and Quran reading became particularly important. (4) Unmet support needs of family caregivers. Family caregivers were affected physically and emotionally by worrying about and caring for the patients. They needed support and training, but often could not access this.DiscussionTruth-telling is highly valued and essential to achieving person-centered care and informed decision-making. This study also reveals specific concerns in conflict-affected populations, reflecting the experience of prior losses and fracturing of existing social networks and support. The role of religion is crucial in supporting refugee communities, and consideration should be paid to the needs of patients and caregivers when caring for a patient at home without access to their communities of origin and the support they accessed.
Population pharmacokinetics and model-based dosing evaluation of bedaquiline in multidrug-resistant tuberculosis patients
Authors: Shao Ge , Bao Ziwei , Davies Forsman Lina , Paues Jakob , Werngren Jim , Niward Katarina , Schön Thomas , Bruchfeld Judith , Alffenaar Jan-Willem , Hu Yi 
Published: March 2023

Aims: Bedaquiline is now recommended to all patients in the treatment of multidrug-resistant tuberculosis (MDR-TB) using standard dosing regimens. As the ability to measure blood drug concentrations is very limited, little is known about drug exposure and treatment outcome. Thus, this study aimed to model the population pharmacokinetics as well as to evaluate the currently recommended dosage.Methodology: A bedaquiline population pharmacokinetic (PK) model was developed based on samples collected from the development cohort before and 1, 2, 3, 4, 5, 6, 8, 12, 18, and 24 h after drug intake on week 2 and week 4 of treatment. In a prospective validation cohort of patients with MDR-TB, treated with bedaquiline-containing standardized regimen, drug exposure was assessed using the developed population PK model and thresholds were identified by relating to 2-month and 6-month sputum culture conversion and final treatment outcome using classification and regression tree analysis. In an exploratory analysis by the probability of target attainment (PTA) analysis, we evaluated the recommended dosage at different MIC levels by Middlebrook 7H11 agar dilution (7H11).Results: Bedaquiline pharmacokinetic data from 55 patients with MDR-TB were best described by a three-compartment model with dual zero-order input. Body weight was a covariate of the clearance and the central volume of distribution, albumin was a covariate of the clearance. In the validation cohort, we enrolled 159 patients with MDR-TB. The 7H11 MIC mode (range) of bedaquiline was 0.06 mg (0.008–0.25 mg/L). The study participants with AUC0-24h/MIC above 175.5 had a higher probability of culture conversion after 2-month treatment (adjusted relative risk, aRR:16.4; 95%CI: 5.3–50.4). Similarly, those with AUC0-24h/MIC above 118.2 had a higher probability of culture conversion after 6-month treatment (aRR:20.1; 95%CI: 2.9–139.4), and those with AUC0-24h/MIC above 74.6 had a higher probability of successful treatment outcome (aRR:9.7; 95%CI: 1.5–64.8). Based on the identified thresholds, simulations showed that the WHO recommended dosage (400 mg once daily for 14 days followed by 200 mg thrice weekly) resulted in PTA &gt;90% for the majority of isolates (94%; MICs ≤0.125 mg/L).Conclusion: We established a population PK model for bedaquiline in patients with MDR-TB in China. Based on the thresholds and MIC distribution derived in a clinical study, the recommended dosage of bedaquiline is sufficient for the treatment of MDR-TB.
The impact of the COVID-19 pandemic on the mental health of new mothers in China: A qualitative study of mothers with infants aged 0–1 year old
Authors: Zou Dandan , Chen Chen 
Published: March 2023

BackgroundChina has implemented a strict epidemic control policy (ECP) for 3 years during the COVID-19 pandemic. New mothers are under great psychological pressure to protect themselves against the virus, following the ECP, as well as taking on the main responsibility of raising their children. However, the mental health of this group has been neglected by the public. This article aims to understand the mental health of new mothers during the COVID-19 pandemic.MethodQualitative research methods were adopted in this study. From 1 October to 1 November 2022, we conducted in-depth interviews with 36 new mothers in Guiyang, Guizhou, China, and used thematic analysis to examine their emotional status, as well as the origins of their negative and positive emotions.Results(1) New mothers are chronically depressed, feeling anxious, and upset. (2) Negative emotions are caused either by the virus or by the ECP. (3) New mothers are mainly anxious about their children's physical health, feeding options, childcare, and family income. (4) Positive emotions are reflected by tight parent–child bonds, a better understanding of childcare, and an increased ability to perceive risks.ConclusionThe anxiety of new mothers has revealed the shortcomings of the Chinese health system in the emergency management of the mother and child. At the same time, the outbreak is an opportunity to improve the response management capacity of the health system in order to prevent the recurrence of similar problems for mothers and infants.
Sperm whales forage year-round in the ross sea region
Authors: Giorli Giacomo , Pinkerton Matthew H. 
Published: March 2023

We investigated the seasonal and spatial occurrence of sperm whale (Physeter macrocephalus) in the Ross Sea region of the Southern Ocean derived from passive acoustic data. Two Autonomous Multichannel Acoustic Recorders (AMARs) moored about 10 m above the seabed were deployed in the austral summer of 2018 and recovered 1 year later. The northern AMAR (A3) was located on the Pacific-Antarctic Ridge at 63.7°S and the southern AMAR (A1) at 73.1°S on the Iselin Bank, part of the continental slope of the Ross Sea. Sperm whale echolocation signals were detected using signal processing scripts and validated by visual inspection of spectrograms. Our results demonstrate that sperm whales are present in the Ross Sea region year-round. At A1, sperm whale vocalisations were detected in every month between February and November, but absent in December and January. Whales were detected most often in February with an average of 0.310 detections per hour. Sperm whale vocalisations were detected at station A3 in every month except February when we had no observations. Our results contrast to a paucity of reported sightings of sperm whales from fishing and research vessels in the Ross Sea region between December and February. Probabilities of detecting sperm whales at A3 were on average 14.2 times higher than at A1 for the same month and monthly mean detections per hour were an average of 74.4 times higher at A3 than A1. At A1, we found a significant preference for day-time foraging rather than during the night or nautical twilight. In contrast, at A3, no clear day/dusk/night/dawn differences in sperm whale occurrence were found. Low sea-ice concentration (&lt; 80%) and open water within ∼50 km were necessary but not sufficient conditions for higher detection rates of sperm whales (&gt;0.1 detections per hour). Overall, our research provides baseline information on sperm whale occurrence and establishes a method to track long-term change to help evaluate the conservation value of the Ross Sea region Marine Protected Area.
Global trends in research of achilles tendon injury/rupture: A bibliometric analysis, 2000–2021
Authors: Wang Chenguang , Jiang Zhaohui , Pang Ran , Zhang Huafeng , Li Hui , Li Zhijun 
Published: March 2023

BackgroundThe Achilles tendon is the strongest and most susceptible tendon in humans. Achilles tendon injuries and ruptures have gradually attracted research attention. However, a bibliometric analysis of global research in this field is lacking. This study involved a bibliometric analysis of the developmental trends and research hotspots in Achilles tendon injuries/ruptures from 2000 to 2021.MethodsArticles published between 2001 and 2021 were retrieved from an extended database of the Science Citation Index using Web of Science. VOSviewer and CiteSpace were used to analyze the relationships between publications, countries, institutions, journals, authors, references, and keywords.ResultsThis study included 3,505 studies of 73 countries, 3,274 institutions, and 12,298 authors and explored the cooperation between them and the relationships between citations. Over the past 22 years, the number of publications has significantly increased. Foot Ankle International has published the most papers on Achilles tendon injuries/ruptures, and British Journal of Sports Medicine is the most famous journal. Re-rupture, exosomes, acute Achilles tendon rupture, and tendon adhesions gradually become the research focus over the past few years.ConclusionAchilles tendon injury and rupture are important research topics. A vast number of newly published papers on this topic have demonstrated that clinicians and researchers are interested in their study. Over time, these recent studies will be widely cited; therefore, this bibliometric analysis should be constantly updated.
Nuovi dati preliminari sulla topografia di Palermo in età medievale
Authors: Spatafora Francesca 
Published: March 2023

Le numerose e preziose occasioni di indagine offerte in anni recenti ha aperto squarci inattesi, oltre che sull’antica storia dell’insediamento punico-romano, anche intorno alle più recenti vicende della città medievale. Nell’area della Galka, coincidente con la paleapolis dell’insediamento antico, le ricerche archeologiche svolte nella zona di Piazza della Vittoria hanno restituito strutture e livelli databili ad età medievale ; la stessa situazione si è riscontrata nel corso dello scavo condotto nell’atrio del Palazzo Arcivescovile di Palermo. Modesta, invece, la quantità di ceramica di età islamica rinvenuta nel corso dell’indagine svolta in un’ampia area prospiciente la Via d’Alessi, sempre all’interno del Qas ¸ r.
Lo scavo, che ha intercettato soprattutto alcune significative testimonianze relative alla vita dell’antico centro urbano di età ellenistica, ha fornito anche qualche utile indicazione per quanto riguarda il medioevo. Decisamente strategica è risultata poi la dislocazione degli scavi realizzati all’interno della Kalsa, soprattutto in relazione al problema della localizzazione della cittadella, al-Ha ¯ lis ¸ a, tema finora trattato più sulla base delle fonti documentarie e storiche che di una oggettiva evidenza archeologica. Significativi in tal senso – soprattutto per quanto riguarda il percorso della cinta muraria e l’estensione di una vasta necropoli di età islamica – le indagini svolte nella Chiesa di Santa Maria della Vittoria, nell’ambito del complesso monumentale dell’Oratorio dei Bianchi, quelle condotte nel sagrato della Chiesa di Santa Maria degli Angeli, detta La Gancia, nonché i saggi realizzati nel cortile di Palazzo Abatellis.
Le Liber donatium et la conquête angevine du royaume de Sicile (1268-1281)
Authors: Pollastri Sylvie 
Published: March 2023

La politique féodale de Charles Ier d’Anjou regarde le rétablissement de l’échelon comtal et la création d’une aristocratie homogène, malgré la diversité des origines, réunie autour du souverain, dont elle partage les plus hautes charges et l’idéal. Le flux migratoire provoqué par l’arrivée de Charles Ier, l’élimination des proditores
des rangs des feudataires sont à l’origine d’un ample renouvellement des titulaires de fiefs. Les permutations de fiefs entre feudataires, les lots démantelés puis reconstitués avec des biens pris ici ou là ont aussi pour but de former des blocs féodaux, de petite ou de grande étendue, mais cohérents et situés dans une même zone géographique. Mais ce n’est pas avant le XIVe siècle que les grandes seigneuries, comme les comtés, vont contenir les mêmes fiefs qu’à l’époque normande. Le liber donationum est le document qui permet aujourd’hui de mesurer directement l’ampleur de ce phénomène. Mais il ne s’agit pas d’un texte authentique que la Reconstruction angevine a transmis à l’historien, malgré les apparences.