bluuebunny/crossref_metadata_2025_split huggingface dataset:
A longitudinal study on the impact of Internet gaming disorder on self‐perceived health, academic performance, and social life of first‐year college students
Authors: Benjet Corina , Orozco Ricardo , Albor Yesica C. , Contreras Eunice V. , Monroy‐Velasco Iris R. , Hernández Uribe Praxedis C. , Báez Mansur Patricia M. , Covarrubias Díaz Couder María A. , Quevedo Chávez Guillermo E. , Gutierrez‐García Raúl A. , Machado Nydia , Andersson Claes , Borges Guilherme 
Published: January 2023

AbstractBackground and ObjectivesInternet gaming disorder (IGD) is associated with health, social, and academic problems but whether these are consequences of the disorder rather than precursors or correlates is unclear. We aimed to evaluate whether IGD in the 1st year of university predicts health, academic and social problems 1 year later, controlling for baseline health, academic and social problems, demographics, and mental health symptoms.MethodsIn a prospective cohort study, 1741 university students completed both a baseline online survey in their 1st year and a follow‐up survey 1 year later. Log‐binomial models examined the strength of prospective associations between baseline predictor variables (IGD, baseline health, academic and social problems, sex, age, and mental health symptoms) and occurrence of health, academic and social problems at follow‐up.ResultsWhen extensively adjusted by the corresponding outcome at baseline, any mental disorder symptoms, sex, and age, baseline IGD was associated only with severe school impairment and poor social life (risk ratio [RR] = 1.77; 95% confidence interval [CI] = 1.14–2.75, p = .011; RR = 1.22; 95% CI = 1.07–1.38, p = .002, respectively).Conclusions and Scientific SignificanceUniversity authorities and counselors should consider that incoming 1st‐year students that meet criteria for IGD are likely to have increased academic and social impairments during their 1st year for which they may want to intervene. This study adds to the existing literature by longitudinally examining a greater array of negative outcomes of IGD than previously documented.
Factors for risk stratification of patients with actinic keratosis using integrated analysis of clinicopathological features and gene expression patterns
Authors: Kim Han‐Na , Kim Hayeon , Gim Jeong‐An , Baek Yoo S. , Kim Aeree , Kim Chungyeul 
Published: January 2023

AbstractBackgroundActinic keratosis (AK) is considered as precursor lesion of invasive squamous cell carcinoma. Molecular studies on AK are limited because of too small size of the biopsy specimen to obtain enough DNA or RNA.MethodsTwenty biopsy cases of AK, followed by second same‐sited biopsies, were included. Ten cases were diagnosed with total regression (regression group), while the other 10 were diagnosed with invasive carcinoma (progression group) in the follow‐up biopsies. Using digital spatial profiling (DSP) technology, whole‐gene expression analysis defined by specific regions of interest was performed for all 20 cases. After the clinicopathological features were assessed, separate and integrated analyses of these features and gene expression patterns were performed using machine‐learning technology. All analyses were performed on both lesion keratinocytes (KT) and infiltrated stromal lymphocytes (LC).ResultsAmong the 18,667 genes assessed, 33 and 72 differentially expressed genes (DEGs) between the regression and progression groups were found in KT and LC respectively. The primary genes distinguishing the two groups were KRT10 for KT and CARD18 for LC. Clinicopathological features were weaker in risk stratification of AK progression than the gene expression patterns. Pathways associated with various cancers were upregulated in the progression group of KT, whereas the nucleotide‐binding oligomerization domain (NOD)‐like receptor signalling pathway was upregulated in the progression of LC.ConclusionGene expression patterns were effective for risk stratification of AK progression, and their distinguishing power was higher than that of clinicopathological features.
Education degree predicts cardiovascular outcomes in men suffering from erectile dysfunction
Authors: Yannas Dimitri , Zago Elena , Cavallini Elena , Todisco Tommaso , Vignozzi Linda , Corona Giovanni , Maggi Mario , Rastrelli Giulia 
Published: January 2023

AbstractBackgroundThe level of education has been recognized as a cardiovascular risk factor; nevertheless, it is often neglected in cardiovascular risk prediction.ObjectivesTo evaluate the psychobiological correlates of the level of education and if it could predict incident major adverse cardiovascular events in men consulting for erectile dysfunction.MethodsTotal 3733 men (49.8 ± 13.7 years old) attending an andrology outpatient clinic for erectile dysfunction were studied. Sexual and psychological symptoms, hormonal and metabolic, as well as instrumental (penile color Doppler ultrasound) parameters were evaluated according to the education level (university, upper secondary, lower secondary, and primary degree). For a subset of 956 patients, data on incident major adverse cardiovascular events were retrospectively collected for 3.9 ± 2.4 years.ResultsAs compared with men with university degree, those with a lower education had an increased frequency of moderate–severe erectile dysfunction (odds ratio = 1.21 [0.99;1.48], 1.41 [1.14;1.73], 1.70 [1.26;2.30] for upper secondary, lower secondary, and primary school, respectively) and reduced flaccid peak systolic velocity at penile color Doppler ultrasound. Men with a lower level of education tend to suffer from metabolic syndrome (odds ratio = 1.38 [1.06;1.79], 1.73 [1.34;2.24], 1.72 [1.24;2.37] for upper secondary, lower secondary, and primary school, respectively) and were more likely to have history of previous cardiovascular events. In the longitudinal study, men with a higher level of education had a significantly lower incidence of major adverse cardiovascular events. The role of higher education as an independent predictor of major adverse cardiovascular events was established by multivariable Cox regressions (hazard ratio = 2.14 [1.24–3.69]).DiscussionIn erectile dysfunction subjects, lower level of education is associated with a more severely impaired erectile function with atherogenic pathogenesis and with a worse cardio‐metabolic profile. In addition, a lower level of education predicts forthcoming major adverse cardiovascular events. Therefore, education level should be considered as a costless but valuable information in the assessment of cardiovascular risk in patients with erectile dysfunction.
Venous thromboembolism risk stratification for patients undergoing surgery for IBD using a novel six factor scoring system using NSQIP‐IBD registry
Authors: Cheong Ju Yong , Connelly Tara M. , Russell Tara , Valente Michael , Bhama Anuradha , Lightner Amy , Hull Tracy , Steele Scott R. , Holubar Stefan D. 
Published: January 2023

AbstractBackgroundPatients undergoing colorectal surgery for inflammatory bowel disease (IBD) are recognized to have an increased risk of venous thromboembolism (VTE). The aim of this study was to determine the perioperative risk factors for VTE and to create a predictive scoring system for VTE in the IBD cohort.MethodsThe NSQIP‐IBD Collaboration Registry from 2017 to 2020 was used to identify patients. Demographics, operative and outcomes data of IBD patients undergoing surgeries for IBD were analysed. A logistic multivariate regression model was performed using all significant variables to develop a predictive scoring system of VTE.ResultsFive‐thousand and three patients (51.9% male, mean age: 42.7, 42.7% ulcerative colitis) were included in the study. 125 (2.49%) developed VTE. On multivariate analysis ASA grade, ulcerative colitis, sepsis, serum sodium <139 mmol/L, an open abdomen and preoperative inter hospital transfer were associated with greater risk of VTE. Using these 6 significant factors, a risk model was constructed. The risk of VTE with one risk factor was 0.7% and 1.8% with two risk factors. The risk of VTE increased to 3.6% and 4.5% with three and four risk factors respectively. With five and six risk factors, the risk of VTE increased exponentially to 10.9% and 25% respectively.ConclusionThis study shows that there are cumulative risk factors which increase the risk of VTE after surgery for IBD. The risk increases exponentially with more than five risk factors, and extended chemoprophylaxis may not be enough in reducing this risk.
When should I eat: A circadian view on food intake and metabolic regulation
Authors: Chamorro Rodrigo , Jouffe Céline , Oster Henrik , Uhlenhaut N. Henriette , Meyhöfer Sebastian M. 
Published: January 2023

AbstractThe circadian clock is a hierarchical timing system regulating most physiological and behavioral functions with a period of approximately 24 h in humans and other mammalian species. The circadian clock drives daily eating rhythms that, in turn, reinforce the circadian clock network itself to anticipate and orchestrate metabolic responses to food intake. Eating is tightly interconnected with the circadian clock and recent evidence shows that the timing of meals is crucial for the control of appetite and metabolic regulation. Obesity results from combined long‐term dysregulation in food intake (homeostatic and hedonic circuits), energy expenditure, and energy storage. Increasing evidence supports that the loss of synchrony of daily rhythms significantly impairs metabolic homeostasis and is associated with obesity. This review presents an overview of mechanisms regulating food intake (homeostatic/hedonic) and focuses on the crucial role of the circadian clock on the metabolic response to eating, thus providing a fundamental research axis to maintain a healthy eating behavior.
Meta‐analysis: Real‐world effectiveness and safety of ustekinumab in patients with ulcerative colitis
Authors: Taxonera Carlos , Olivares David , López‐García Olga N. , Alba Cristina 
Published: January 2023

SummaryBackgroundEvidence on real‐world outcomes of ustekinumab for ulcerative colitis (UC) patients is needed.AimsTo summarise evidence on the real‐world outcomes of ustekinumab for UC and conduct a meta‐analysis of effectiveness and safety data.MethodsA systematic search was conducted through September 2022 in electronic databases for observational studies evaluating ustekinumab for UC. A random‐effects meta‐analysis model was used to calculate the pooled effect sizes (percentages or incidence rates [IRs]) of effectiveness and safety outcomes.ResultsIn all, 19 studies were included with 3786 patients. More than 92% of patients were previously treated with any biologic, 61.1% with both anti‐TNF and vedolizumab and 16.4% with any biologic and tofacitinib. Clinical remission was achieved in 45.4% at week 8 (95% CI: 30.1%–60.6%), 43.8% (38.4%–49.2%) at weeks 12–16, 44.6% (35.9%–53.3%) at month 6, and 50.6% (36.3%–64.8%) at month 12. Response was achieved in 61.2%, 59.4%, 65.2% and 76.8% at weeks 8, 12–16, month 6 and 12, respectively. CS‐free remission was achieved in 18.7%, 36.8%, 34.5% and 39% at weeks 8, 12–16, month 6 and 12, respectively. Overall, 58.2% of patients had endoscopic improvement at month 12. Almost 30% of the patients needed dose escalation, which was effective in 40% of these patients. The IRs of colectomy, adverse events (AEs), serious AEs and serious infections were 4.8, 7.9, 0.8 and 0.3 per 100 patient‐years, respectively.ConclusionsThis meta‐analysis confirms the effectiveness and safety of ustekinumab in a highly treatment‐refractory population of UC patients.
Evaluation of thyroid function monitoring in people treated with lithium: Advice based on real‐world data
Authors: Duce Helen L. , Duff Christopher J. , Zaidi Syed , Parfitt Ceri , Heald Adrian H. , Fryer Anthony A. 
Published: January 2023

AbstractIntroductionBlood test monitoring is essential for the management of lithium treatment and National Institute for Health and Care Excellence guidance recommends 6‐monthly serum testing of thyroid function. We examined conformity to these guidelines and the impact of monitoring outside these intervals.MethodsWe extracted serum lithium and thyroid hormone results at one centre between January 2009 and December 2020. We identified 266 patients who started lithium during this period with no history of thyroid abnormality within the previous 2 years and were at risk of developing thyroid abnormalities. We examined the interval between tests, time between onset of lithium testing and first thyroid‐stimulating hormone (TSH) outside the laboratory reference range and assessed impact of testing outside recommended 6‐monthly intervals.ResultsThe most common testing frequency was 3 months (±1 month), accounting for 17.3% of test intervals. Kaplan‐Meier analysis showed that most thyroid dysfunction manifests within 3 years (proportion with abnormal TSH at 3 years = 91.4%, 19.9% of total patients). In the first 3 months after commencing lithium therapy, eight patients developed subclinical hypothyroidism and had clinical follow‐up data available. Of these, half spontaneously normalized without clinical intervention. In the remaining patients, thyroxine replacement was only initiated after multiple occasions of subclinical hypothyroidism (median = 2 years after initiating lithium, range: 6 months to 3 years).ConclusionThe peak interval at 3 months suggests that thyroid function is frequently checked at the same time as serum lithium, indicating too frequent testing. Our data support the recommended 6‐monthly testing interval and highlight poor adherence to it.
Entropy Balancing for Causal Generalization with Target Sample Summary Information
Authors: Chen Rui , Chen Guanhua , Yu Menggang 
Published: January 2023

Abstract
In this paper, we focus on estimating the average treatment effect (ATE) of a target population when individual-level data from a source population and summary-level data (e.g., first or second moments of certain covariates) from the target population are available. In the presence of the heterogeneous treatment effect, the ATE of the target population can be different from that of the source population when distributions of treatment effect modifiers are dissimilar in these two populations, a phenomenon also known as covariate shift. Many methods have been developed to adjust for covariate shift, but most require individual covariates from a representative target sample. We develop a weighting approach based on the summary-level information from the target sample to adjust for possible covariate shift in effect modifiers. In particular, weights of the treated and control groups within a source sample are calibrated by the summary-level information of the target sample. Our approach also seeks additional covariate balance between the treated and control groups in the source sample. We study the asymptotic behavior of the corresponding weighted estimator for the target population ATE under a wide range of conditions. The theoretical implications are confirmed in simulation studies and a real-data application.
The relationship between numerical mapping abilities, maths achievement and socioeconomic status in 4‐ and 5‐year‐old children
Authors: Short Dawn S. , McLean Janet F. 
Published: January 2023

AbstractBackgroundEarly numeracy skills are associated with academic and life‐long outcomes. Children from low‐income backgrounds typically have poorer maths outcomes, and their learning can already be disadvantaged before they begin formal schooling. Understanding the relationship between the skills that support the acquisition of early maths skills could scaffold maths learning and improve life chances.AimsThe present study aimed to examine how the ability of children from different SES backgrounds to map between symbolic (Arabic numerals) and non‐symbolic (dot arrays) at two difficulty ratios related to their math performance.SampleParticipants were 398 children in their first year of formal schooling (Mean age = 60 months), and 75% were from low SES backgrounds.MethodThe children completed symbolic to non‐symbolic and non‐symbolic to symbolic mapping tasks at two difficulty ratios (1:2; 2:3) plus standardized maths tasks.ResultsThe results showed that all the children performed better for symbolic to non‐symbolic mapping and when the ratio was 1:2. Mapping task performance was significantly related to maths task achievement, but low‐SES children showed significantly lower performance on all tasks.ConclusionThe results suggest that mapping tasks could be a useful way to identify children at risk of low maths attainment.
Targeting polymerase θ impairs tumorigenesis and enhances radiosensitivity in lung adenocarcinoma
Authors: Rao Xinrui , Xing Biyuan , Wu Zilong , Bin Yawen , Chen Yunshang , Xu Yingzhuo , Zhou Dong , Zhou Xiaoshu , Wu Chuangyan , Ye Wang , Chen Weibin , Wang Geng , Zhang Sheng , Dong Xiaorong , Meng Rui , Wu Gang , Zhou Rui 
Published: January 2023

AbstractRadioresistance remains a major obstacle to efficacious radiotherapy in non–small‐cell lung cancer (NSCLC). DNA replication proteins are novel targets for radiosensitizers. POLQ is a DNA polymerase involved in DNA damage response and repair. We found that POLQ is overexpressed in NSCLC and is clinically correlated with high tumor stage, poor prognosis, increased tumor mutational burden, and ALK and TP5 mutation status; POLQ inhibition impaired lung tumorigenesis. Notably, POLQ expression was higher in radioresistant lung cancer cells than in wild‐type cancer cells. Moreover, POLQ expression was further increased in radioresistant cells after radiation. Enhanced radioresistance is through a prolonged G2/M phase and faster repair of DNA damage, leading to reduced radiation‐induced apoptosis. Novobiocin (NVB), a POLQ inhibitor, specifically targeted cancer cells. Genetic knockdown of POLQ or pharmacological inhibition by NVB decreased radioresistance in lung adenocarcinoma while causing little toxicity to normal pulmonary epithelial cells. In conclusion, POLQ is a promising and practical cancer‐specific target to impair tumorigenesis and enhance radiosensitivity in NSCLC.
Caseworkers as a source of hope leading to perceptions of academic success for transitional age foster youth
Authors: Pharris Angela B. , Muñoz Ricky T. , Hellman Chan M. 
Published: January 2023

AbstractResearch among adolescent samples has consistently demonstrated that a hopeful mindset is associated with resilience and global well‐being. Further, research suggests that hope is influenced from an early age from connections with supportive caregivers. However, because older youth in the child welfare system may lack supportive caregivers, alternative sources of hope may be needed. To test a theory that supportive child welfare caseworkers can serve as external sources of hope, we conducted a cross‐sectional study of youth in the child welfare system from a single state (N = 149). Using surveys with established scales to measure the variables of interest, the study tested a structural equation model of (1) youth's external hope in their caseworker as a driver of (2) internal hope in themselves leading to (3) more positive perceptions of academic success. Perceptions of academic success were chosen as the final consequence of the model because academic success has been linked to many other variables of well‐being across the lifespan. The results indicate that the proposed structural model fits the data well (χ2 = 327.9, df = 150; P < 0.001; root‐mean‐square error of approximation [RMSEA] = 0.09 [90% confidence interval – CI: 0.076, 0.103]; comparative fit index [CFI]: 0.920; standardized root‐mean‐square residual [SRMR]: 0.05). The results indicate that youths' hope in themselves had origins in external hope in the caseworker. Moreover, the final consequence was an increase in perceptions of academic success. Such results have implications by revealing how case management services can positively influence foster youths' hope and thereby influence their academic success.
Exploring patient experiences and concerns in the online Cochlear implant community: A cross‐sectional study and validation of automated topic modelling
Authors: Williams Christopher Y. K. , Li Rosia X. , Luo Michael Y. , Bance Manohar 
Published: January 2023

AbstractObjectiveThere is a paucity of research examining patient experiences of cochlear implants. We sought to use natural language processing methods to explore patient experiences and concerns in the online cochlear implant (CI) community.Materials and MethodsCross‐sectional study of posts on the online Reddit r/CochlearImplants forum from 1 March 2015 to 11 November 2021. Natural language processing using the BERTopic automated topic modelling technique was employed to cluster posts into semantically similar topics. Topic categorisation was manually validated by two independent reviewers and Cohen's kappa calculated to determine inter‐rater reliability between machine vs human and human vs human categorisation.ResultsWe retrieved 987 posts from 588 unique Reddit users on the r/CochlearImplants forum. Posts were initially categorised by BERTopic into 16 different Topics, which were increased to 23 Topics following manual inspection. The most popular topics related to CI connectivity (n = 112), adults considering getting a CI (n = 107), surgery‐related posts (n = 89) and day‐to‐day living with a CI (n = 85). Cohen's kappa among all posts was 0.62 (machine vs. human) and 0.72 (human vs. human), and among categorised posts was 0.85 (machine vs. human) and 0.84 (human vs. human).ConclusionsThis cross‐sectional study of social media discussions among the online cochlear implant community identified common attitudes, experiences and concerns of patients living with, or seeking, a cochlear implant. Our validation of natural language processing methods to categorise topics shows that automated analysis of similar Otolaryngology‐related content is a viable and accurate alternative to manual qualitative approaches.
The Spillover Effects of Environmental Regulations: A Perspective of Chinese Unregulated Firms' Tax Burden
Authors: Geng Yong , Liu Wei , Chen Hanshu , Zou Xinyu 
Published: January 2023

AbstractPrevious studies focus on the direct impacts of environmental regulations while paying less attention to spillover effects. Taking the Eleventh Five‐year Plan in China as a quasi‐natural experiment, our results show that environmental regulations significantly increase the tax burden of unregulated firms. Environmental regulations generate spillover effects on firms that should not be subjected to regulatory policies. Further channel analysis shows that the fiscal pressure of local governments caused by environmental regulations is a major channel for the increase in the tax burden of unregulated firms. Finally, according to the heterogeneity results, the spillover effects are more pronounced in small firms, non‐state‐owned enterprises, and provinces with stricter enforcement. Our findings emphasize the additional costs of environmental policies, and the government should consider these costs when formulating policies.
Total Factor Productivity in China's Manufacturing Sector in the Aftermath of the Global Financial Crisis
Authors: Shen Guangjun , Zou Jingxian 
Published: January 2023

AbstractThis paper improves the estimation of firm‐level total factor productivity (TFP) by considering energy use and including small‐ and medium‐sized enterprises using data from the Chinese National Tax Survey Database (2008–2011). It analyzes the production efficiency of Chinese manufacturing firms using the improved TFP data and finds that (i) the TFP data frequently used in previous studies overestimated firms' real production efficiency; (ii) the TFP of manufacturing firms decreased from 2008 to 2011 due to declines in both technical efficiency and allocation efficiency; (iii) the lower capacity utilization of production factors led to lower technical efficiency; and (iv) allocation efficiency decreased more in provinces and industries with higher shares of state‐owned enterprises. The findings have policy implications for enhancing growth potential in the long run.