bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polarity‐selective Transfer of Lipophilic Cargoes From Lipid Droplets (Oleosomes) to Lipid Bilayers
Authors: Vardar Umay Sevgi , Bitter Johannes H. , Nikiforidis Constantinos V. 
Published: January 2025

AbstractLipid Droplets (LDs) or as also called oleosomes are lipid storage organelles in eukaryotic cells. Besides storing lipids, LDs can fuse their core into other intracellular organelles, but the mechanism remains unknown. In this work, this is aimed to understand the effect of cargo's polarity on the transportation of the cargo from LDs to lipid bilayers using liposomes. LDs are loaded with curcumin and Nile red, two lipophilic molecules with similar log P values. The loaded LDs are blended with liposomes, while curcumin and Nile red are tracked using confocal microscopy and spectroscopy. LDs remained intact, while curcumin was transferred in 5 min from LDs to liposomes. Nile red remained in LDs. The difference between curcumin and Nile red is attributed to the amphiphilicity of curcumin, which allowed its adsorption in the LD monolayer and the subsequent transportation to the liposome bilayer upon contact. The unique selectivity of LDs is shown as carriers since lipophilic cargo is transferred to the lipid bilayer only when participating in the LD membrane. The understanding of the transportation mechanism of molecules from LDs to bilayers helps the exploitation of LDs as natural lipid carriers.
Highly Sensitive Solar‐Blind Ultraviolet Photodetectors and 64 × 64 Photodetector Arrays Realized by Molecule Beam Epitaxy Grown Ga2O3 Epitaxial Thin Films
Authors: Kuang Siliang , Yang Zhenni , Xu Xiangyu , He Yaxin , Bao Lingjie , Liang Zheng , Li Kuangkuang , Ling Kang , Zhang Xu , Yang Ye , Long Hao , Cheng Qijin , Liu Xingzhao , Chen Duanyang , Qi Hongji , Zhang Kelvin H. L. 
Published: January 2025

AbstractGallium oxide (Ga2O3) emerges as the most promising semiconductor for next‐generation solar‐blind UV photodetectors (SBPDs) because of its ultra‐wide bandgap of 4.85 eV. However, so far Ga2O3 based SBPDs still suffer from problems such as high dark current and slow response speed. Herein, the fabrication of metal‐semiconductor‐metal (MSM) structures Ga2O3 SBPDs with high performance using high‐quality Ga2O3 epitaxial thin films grown by molecule beam epitaxy (MBE) is reported. The SBPDs are highly sensitive to solar‐blind UV spectrum and achieve a very low dark current of 273 fA at 10 V bias, a high specific detectivity of 1.6 × 1016 Jones with a responsivity of 167 A W−1, and a remarkedly rapid response speed with a decay time of 15 ms. The specific detectivity, dark current, and response speed of the SBPD achieve in this work are among the highest levels in the literature. The enhanced device performance is attributed to high crystalline quality of the film with reduced density of defects and fast photocarrier dynamics. Furthermore, a 64 × 64 photodetector array with high uniformity is fabricated on a 2‐inch Ga2O3 epitaxial wafer, achieving the highest pixel count for Ga2O3 photodetector array to date. This study paves the way for the development of fast‐speed Ga2O3 SBPDs with high sensitivity and large‐scale photodetector arrays.
M6A Demethyltransferase FTO Attenuates Meniscus Degeneration and Osteoarthritis via Orchestrating Autophagy and Energetic Metabolism
Authors: Jiang Zongrui , Zhang Chengyun , Liu Ruonan , Zhu Zijing , Long Dianbo , Wen Xingzhao , Yang Zhijian , Jiang Dong , Mao Guping , Liao Weiming , Zhang Zhiqi 
Published: January 2025

AbstractImpaired autophagy is reported to promote osteoarthritis (OA). However, the mechanism by which autophagy in regulating meniscus degeneration and OA remains unclear. Here, unconvered aberrant energetic metabolism pattern in meniscus cells with OA is uncovered first, which results in lower adenosine triphosphate (ATP) production. And these phenomena are induced by impaired autophagy in meniscus cells with OA. It is further revealed that the suppression of m6A demethylase fat mass and obesity‐associated protein (FTO) inhibits autophagy and causing lower ATP production by reducing oxidative phosphorylation. Specific deletion of FTO in meniscus cells by generating FTOflox/flox; COL1A1‐CreERT2 (FTOcko) mice impair autophagy and promote meniscus degeneration and OA, while intra‐articular injection of adeno‐associated virus of FTO (AAV‐FTO) restores autophagy and alleviates meniscus degeneration and OA. Mechanistically, FTO regulates the mRNA stability of ATG16L1 by targeting the m6A methylation sites on ATG16L1 in a YTHDF2‐dependent manner, thereby inhibiting the formation of autophagosomes and causing an imbalance in energetic metabolism. Intra‐articular injection of AAV‐FTO reverses the catabolic phenotype of meniscus degeneration and OA in FTOcko mice. In summary, these findings reveal FTO orchestrates autophagy and energetic metabolism by regulating ATG16L1 in a m6A‐dependent manner. Therefore, targeting FTO might be a potential therapeutic strategy for meniscus degeneration and early‐stage OA.
Operando X‐Ray Tomoscopy of Laser Beam Welding
Authors: Kamm Paul Hans , Börner Stephan , Neu Tillmann Robert , Schlepütz Christian Matthias , Dittrich Dirk , Banhart John , García‐Moreno Francisco 
Published: January 2025

AbstractThe phenomena occurring in a weld seam during advancement of a laser beam over a metallic component are still under dispute. The occurrence and evolution of porosity and the occasional blowout of melt need to be understood. Here, a recently developed X‐ray tomoscopy setup is applied, providing one hundred 3D images per second to capture the temporal evolution of the melt pool in an AlSi9Cu3(Fe) die‐casting while a laser beam advances. The number of pores, their size, shape and distribution are quantified with 10 ms time resolution and reflect a complex dynamic pattern. Apart from conventional welding, a variant involving a dynamic beam modulation superimposed onto the linear motion is studied. Reductions of porosity and surface roughness are observed and explained by increased pore mobility and stepwise degassing as the beam repeatedly cuts through pores. The keyhole formed in the melt pool integrated over 10 ms is represented in 3D.
Synthesis and Conformational Relationship of New Fluorinated Acrylate Polymer‐Based Internal Mold Release Agents
Authors: Zhang Jingang , Huang Zhensheng , Xu Jianyin , Wang Tao , Sun Dongping , Jia Zhenyu , Zhou Lu 
Published: January 2025

ABSTRACTThis study employed short fluorocarbon chain perfluorohexylethyl methacrylate (PFOL, R
f = 6) and long hydrocarbon chain Stearyl acrylate (SA, R = 18) to synthesize a series of fluorinated acrylate polymers (FAP) via solution polymerization. The copolymerization rates of PFOL and SA were calculated, and the copolymer composition curves were plotted to produce FAP with uniform composition and varying PFOL ratios. Experiments revealed that these FAP demonstrated significant dissolution and migration behaviors during the processing of fluoroelastomers, influenced by the PFOL to SA ratio. The optimized FAP (PFOL ratio of 0.7), with a weight‐average molecular weight between 23,000 and 26,000, significantly reduced the demolding force of fluoroelastomer O‐rings from 49 to 20 N. Water contact angle and demolding force tests further verified the internal mold release effects of the FAP. Predictions from the CISOC‐PSAT program indicate that the FAP synthesized in this study is less toxic compared to the copolymer of perfluorooctylethyl methacrylate (POEMA) and SA, with negative results for carcinogenic and mutagenic toxicity, demonstrating its potential as an environmentally friendly, green fluorine‐containing internal mold release agent.
FragMAX Facility for Crystallographic Fragment and Ligand Screening at MAX IV
Authors: Kanchugal P. Sandesh , Jagudin Elmir , Lima Gustavo M. A. , Talibov Vladimir O. , Begum Afshan , Nan Jie , Eguiraun Mikel , Gonzalez Ana , Sele Céleste , Nyblom Maria , Knecht Wolfgang , Logan Derek T. , Sjögren Tove , Thunnissen Marjolein , Ursby Thomas , Obiols‐Rabasa Marc , Larsson Magnus , Mueller Uwe , Krojer Tobias 
Published: January 2025

ABSTRACTThe FragMAX facility at MAX IV Laboratory is a state‐of‐the‐art platform for crystallographic fragment screening, designed to support structure‐based drug and chemical tool compound discovery. This facility offers a comprehensive workflow, from high‐throughput crystal preparation and automated diffraction data collection at the BioMAX beamline to advanced data processing and analysis using custom software tools like FragMAXapp and FragMAXproc. Key components include an extensive relational SQLite database, various fragment libraries, laboratory automation equipment, and a range of bespoke software solutions. FragMAX has conducted numerous successful screening campaigns, serving both academic and industrial users. Users benefit from comprehensive support, and stringent data management. Here, we provide an overview of the different components of the facility and details of their practical implementation.
Quantum Mechanics in Plasmonic Nanocavities: from Theory to Applications
Authors: Ding Tao , Tserkezis Christos , Mystilidis Christos , Vandenbosch Guy A. E. , Zheng Xuezhi 
Published: January 2025

AbstractQuantum mechanical effects in plasmonic nanocavities have attracted strong interest in the last two decades, related to both their experimental realization and implementation in technological applications, and to the challenges that need to be overcome in their theoretical modeling. This review summarizes the basic theories of quantum plasmonics, its modeling strategies, and the material systems that support it. Particularly it is focused on recent progress in quantum plasmonics based on the nanoparticle‐on‐mirror (NPoM) structure, i.e., plasmonic nanoparticles separated from an underlying metallic substrate via an ultrathin spacer, which provides an elegant route toward cost‐effective fabrication of a large number of similar plasmonic cavities. A dramatic shift of research trends is seen from basic modeling to applications in nano‐optics, polaritonics, chemistry, and biosensing, gradually making the transition from fundamental, curiosity‐driven research to applied science.
The discovery of a new nonbile acid modulator of Takeda G protein‐coupled receptor 5: An integrated computational approach
Authors: Salam Rudy , Bakker Michael , Krutáková Mária , Štefela Alžbeta , Pávek Petr , Duintjer Tebbens Jurjen , Zitko Jan 
Published: January 2025

AbstractThe Takeda G protein‐coupled receptor 5 (TGR5), also known as GPBAR1 (G protein‐coupled bile acid receptor), is a membrane‐type bile acid receptor that regulates blood glucose levels and energy expenditure. These essential functions make TGR5 a promising target for the treatment of type 2 diabetes and metabolic disorders. Currently, most research on developing TGR5 agonists focuses on modifying the structure of bile acids, which are the endogenous ligands of TGR5. However, TGR5 agonists with nonsteroidal structures have not been widely explored. This study aimed at discovering new TGR5 agonists using bile acid derivatives as a basis for a computational approach. We applied a combination of pharmacophore‐based, molecular docking, and molecular dynamic (MD) simulation to identify potential compounds as new TGR5 agonists. Through pharmacophore screening and molecular docking, we identified 41 candidate compounds. From these, five candidates were selected based on criteria including pharmacophore features, a docking score of less than 9.2 kcal/mol, and similarity in essential interaction patterns with a reference ligand. Biological assays of the five hits confirmed that Hit‐3 activates TGR5 similarly to the bile acid control. This was supported by MD simulation results, which indicated that a hydrogen bond interaction with Tyr240 is involved in TGR5 activation. Hit‐3 (CSC089939231) represents a new nonsteroidal lead that can be further optimized to design potent TGR5 agonists.
The Influence of Recycled Packaging for Food Products on Consumer Behavior
Authors: Trinh Can , He Ping , An Lam 
Published: January 2025

ABSTRACTExtensive efforts by both government and private sectors to make the use of recycled packaging in food products more prevalent have not always been successful, partly due to a limited understanding of consumers' complex perceptions towards this practice. In this research, we explore whether recycled food product packaging enhances the appeal of food products, as well as the boundary condition and underlying mechanism of this effect. Using three experimental studies, we find that marketing efforts highlighting the use of recycled packaging can be beneficial, but only for utilitarian food products, not for hedonic ones. We also identify the warm‐glow effect as a key mediating mechanism. This study uniquely contributes to the literature by not only examining the differential effects of recycled packaging but also identifying the warm‐glow effect as a key mediating mechanism. Our findings contribute a more nuanced perspective to the literature on sustainable consumption and provide practical implications for enhancing the effectiveness of recycled food product packaging.
Integrated of Hyperspectral Imaging and Machine Learning Algorithms for Nondestructive Detection of Therapeutic Properties of Plants
Authors: Mahmoodi‐Eshkaftaki Mahmood , Mohtashami Saeideh , Parseh Mohammad Javad , Ghani Askar 
Published: January 2025

ABSTRACTThe approaches used to determine the medicinal properties of the plants are often destructive, labor‐intensive, time‐consuming, and expensive, making it impossible to analyze their quality analysis online. Performance of hyperspectral imaging (HSI) integrated with intelligent techniques to overcome these problems was investigated in this research. For this purpose, three classification methods—support vector machine, random forest (RF), and extreme gradient boosting—were studied for the classification of plants in three classes of medicinal, edible, and ornamental for the organs of leaf, stem, flower, and root. The medicinal effects of the plant organs were determined by measuring different biochemical properties of the organs. The spectral reflectance of the samples was used to train and test the classification methods in which output targets were the plant types. The results showed that amounts of the biochemical factors except oil content of the medicinal plants were higher than the other types of plants. Further, the biochemical factors of flowers and leaves were higher than the other organs indicating that the most therapeutic effect of the plants is through the flowers and leaves. Using HSI, a similar spectral trend was appeared in each organ, whereas it was different among the organs. Using the RF as the best method (precision and accuracy were higher than 0.95), the lowest misclassification rates were related to the stem and leaf datasets, indicating that these two organs were most suitable to classify the plants aromatically. The most misclassifications of the organs were occurred between medicinal and edible plants related to the spectra having higher correlations with flavonoid, phenol, and antioxidant compounds. Overall, the misclassification rates were negligible, and thus, the methods developed in this study can be used online in postharvest processes of the medicinal plants.
Licorice‐Induced Pseudohyperaldosteronism: A Case Report
Authors: Je David D. , Tan Yong Mong , Fuller Gradon , Nigam Parul 
Published: January 2025

ABSTRACTWe present a 71‐year‐old man admitted to the intensive care unit with severe hypokalemia after ingesting licorice‐containing confectionary over 6 weeks. Excess consumption of licorice with its active metabolite glycyrrhizic acid may precipitate pseudohyperaldosteronism with life‐threatening hypokalemia. Public awareness and measures such as warning labels are needed to warn against excessive consumption.
Retroperitoneal Soft Tissue Sarcoma and Kidney Autotransplantation: A Case Report
Authors: Hakkesteegt S. N. , Oudmaijer C. A. J. , Jeletich L. J. , Sprakel J. , Kimenai H. J. A. N. , Grünhagen D. J. 
Published: January 2025

ABSTRACTSoft tissue sarcomas (STSs) are rare malignancies, with retroperitoneal soft tissue sarcoma (RPS) constituting 10%–15% of all STSs. RPS often presents late due to minimal early symptoms, typically requiring complete en‐bloc resection for optimal survival outcomes. Achieving radical resection can be challenging due to the tumor's proximity to vital organs. In cases where the kidney is involved, a nephrectomy can lead to significant morbidity, especially in patients with pre‐existing renal impairment. Kidney autotransplantation offers a unique solution by preserving renal function in these cases, avoiding the need for dialysis and immunosuppressive therapy. This case report presents a 61‐year‐old female with a large RPS encasing her only functioning kidney. After unsuccessful neoadjuvant chemotherapy, she underwent an en‐bloc resection and subsequent autotransplantation. Postoperatively, she experienced complications such as pneumonia and bowel obstruction due to poor clinical status, but after recovery, she has remained disease‐free at 1‐year follow‐up. This case illustrates the potential of kidney autotransplantation in selected cases to prevent treatment‐induced renal failure. Although the risk of recurrence is relevant, autotransplantation provides an option for preserving renal function while allowing for curative resection, with careful consideration of the balance between recurrence risk and morbidity.
Structures and Properties of Axially Chiral (2E,4E,6Z,8Z)‐Nona‐2,4,6,8‐Tetraenoate Derivatives Highly Substituted by Aryl Groups
Authors: Echizen Kensuke , Akine Shigehisa , Furuyama Taniyuki , Nishimura Tatsuya , Maeda Katsuhiro , Taniguchi Tsuyoshi 
Published: January 2025

AbstractUnprecedented (2E,4E,6Z,8Z)‐nona‐2,4,6,8‐tetraenoate derivatives highly substituted by aryl groups have been synthesized by the reaction of rhodium complexes having aryl‐substituted hexa‐1,3,5‐trienyl ligands with acrylates. These compounds have potential axial chirality, and their enantiomers are isolable by the chiral HPLC technique. Although the racemization barrier of isolated enantiomers was not high, it was found that a cyclic dimer synthesized by head‐to‐tail transesterification of a modified analog has quite a stable axial chirality even at a high temperature. From a structural analogy with tetraphenylethene, those compounds are emissive in the solid state, and the chiral cyclic dimer exhibits solid‐state circularly polarized luminescence (CPL) activity.
Peptide–Bismuth Tricycles: Maximizing Stability by Constraint
Authors: Davies Lani J. , Ghosh Pritha , Siryer Sauhta , Ullrich Sven , Nitsche Christoph 
Published: January 2025

AbstractConstrained peptides possess excellent properties for identifying lead compounds in drug discovery. While it has become increasingly straightforward to discover selective high‐affinity peptide ligands, especially through genetically encoded libraries, their stability and bioavailability remain significant challenges. By integrating macrocyclization chemistry with bismuth binding, we generated series of linear, cyclic, bicyclic, and tricyclic peptides with identical sequences. Utilizing bismuth to rigidify the peptide structure allows for a better comparison of different constraint levels, reducing confounding effects of interactions often seen with hydrophobic stapling reagents. Our study facilitated the identification of a peptide–bismuth tricycle that fully withstands cellular levels of glutathione, acts as a nanomolar protease inhibitor without being proteolytically digested by its target, and is fully stable in human plasma. Importantly, this multicyclic peptide does not possess any non‐canonical amino acid modifications. Using oxime ligation, we conjugated an analogue of this tricycle to the N‐terminus of two nanobodies to demonstrate potential applications in targeted therapy.
Enantioselective Degradation and Processing Factors of Seven Chiral Pesticides During the Processing of Wine and Rice Wine
Authors: Tan Yuting , Wen Nuanhui , Lu Zhiqiang , Wei Wenjie , Shi Haiyan , Wang Minghua 
Published: January 2025

ABSTRACTChiral pesticides often undergo enantioselective degradation during food fermentation. In this study, the enantioselective fates of seven chiral pesticides during processing of wine and rice wine were investigated. The results revealed that R‐metalaxyl, R‐mefentrifluconazole and S‐hexaconazole were preferentially degraded during wine processing with EF values of 0.57, 0.78, and 0.43, respectively, whereas S‐metalaxyl and R‐hexaconazole were preferentially degraded during rice wine processing with EF values of 0.44 and 0.54, respectively. Stereoselectivity was attributed to fermentative bacterial activity. The processing factor (PF) values for the five pesticides ranged from 0.04 to 0.34 during wine processing and from 0.02 to 0.29 during rice wine processing, suggesting that fermentation can mitigate pesticide exposure risks and ensure food safety. This study enhances our understanding of enantioselective fate of chiral pesticides during fermented food processing, provides guidance for the application of chiral pesticides, and enables the dietary risk of chiral pesticides in processed products to be assessed more accurately.
Patient‐Reported Outcomes Following Systemic Antibiotic Adjunct to Nonsurgical Treatment of Periodontitis: A Randomized Controlled Clinical Trial
Authors: Parhizkar Parastoo , Yaghini Jaber , Fakheran Omid 
Published: January 2025

ABSTRACTObjectivesConsidering the importance of patient‐centered care, we aimed to evaluate the impact of systemic antibiotics on oral health–related quality of life during nonsurgical periodontal treatment. This controlled trial addresses a gap in understanding how systemic antibiotics influence patient‐reported outcomes, focusing on Stage III periodontitis.Materials and MethodsSixty‐one adults participated in a double‐blind, randomized clinical trial, with participants divided into two groups: the test group, which received antibiotics, and the control group. All the participants received nonsurgical periodontal treatment. We conducted follow‐up assessments at one and 3 months posttreatment, including recording clinical parameters and administering the Oral Health Impact Profile‐14 (OHIP‐14) questionnaire.ResultsThe results showed a notable improvement in the quality of life for patients in the test group compared to the control group at 1 month (p value = 0.012) and 3 months (p value = 0.014) after treatment. While there were improvements in pocket probing depth, gingival index, and clinical attachment loss in both groups, it is worth noting that only bleeding on probing exhibited a significant improvement in the test group after 3 months compared to the control group (p value = 0.008).ConclusionsIn summary, incorporating systemic antibiotics alongside nonsurgical periodontal treatments appears to bring about positive outcomes for individuals dealing with Stage III periodontitis during nonsurgical treatment, ultimately enhancing their oral health‐related quality of life.Trial RegistrationIranian Registry of Clinical Trials (IRCT Id): IRCT20201221049786N1.