bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancement of acetate production in hydrogen-mediated microbial electrosynthesis reactors by addition of silica nanoparticles
Authors: Pan Zeyan , Liu Zhuangzhuang , Hu Xiaona , Cui Kai , Cai Wenfang , Guo Kun 
Published: January 2023

AbstractMicrobial electrosynthesis (MES) is a promising technology for CO2 fixation and electrical energy storage. Currently, the low current density of MES limits its practical application. The H2-mediated and non-biofilm-driven MES could work under higher current density, but it is difficult to achieve high coulombic efficiency (CE) due to low H2 solubility and poor mass transfer. Here, we proposed to enhance the hydrogen mass transfer by adding silica nanoparticles to the reactor. At pH 7, 35 ℃ and 39 A·m− 2 current density, with the addition of 0.3wt% silica nanoparticles, the volumetric mass transfer coefficient (kLa) of H2 in the reactor increased by 32.4% (from 0.37 h− 1 to 0.49 h− 1), thereby increasing the acetate production rate and CE of the reactor by 69.8% and 69.2%, respectively. The titer of acetate in the reactor with silica nanoparticles (18.5 g·L− 1) was 56.9% higher than that of the reactor without silica nanoparticles (11.8 g·L− 1). Moreover, the average acetate production rate of the reactor with silica nanoparticles was up to 2.14 g·L− 1·d− 1 in the stable increment phase, which was much higher than the other reported reactors. These results demonstrated that the addition of silica nanoparticles is an effective approach to enhancing the performance of H2-mediated MES reactors.
Graphical Abstract
Verapamil-loaded supramolecular hydrogel patch attenuates metabolic dysfunction-associated fatty liver disease via restoration of autophagic clearance of aggregated proteins and inhibition of NLRP3
Authors: Kim Do Kyung , Han Daewon , Bae Jeongyun , Kim Haeil , Lee Solji , Kim Jong-Seok , Jeong Young-Gil , Shin Jongdae , Park Hwan-Woo 
Published: January 2023

Abstract

Background
Obesity, a serious threat to public health, is linked to chronic metabolic complications including insulin resistance, type-2 diabetes, and metabolic dysfunction-associated fatty liver disease (MAFLD). Current obesity medications are challenged by poor effectiveness, poor patient compliance, and potential side effects. Verapamil is an inhibitor of L-type calcium channels, FDA-approved for the treatment of hypertension. We previously investigated the effect of verapamil on modulating autophagy to treat obesity-associated lipotoxicity. This study aims to develop a verapamil transdermal patch and to evaluate its anti-obesity effects.

Methods
Verapamil is loaded in biomimetic vascular bundle-like carboxymethyl pullulan-based supramolecular hydrogel patches cross-linked with citric acid and glycerol linkages (CLCMP). The investigation was then carried out to determine the therapeutic effect of verapamil-loaded CLCMP (Vera@CLCMP) on diet-induced obese mice.

Results
Vera@CLCMP hydrogel patches with hierarchically organized and anisotropic pore structures not only improved verapamil bioavailability without modifying its chemical structure but also enhanced verapamil release through the stratum corneum barrier. Vera@CLCMP patches exhibit low toxicity and high effectiveness at delivering verapamil into the systemic circulation through the dermis in a sustained manner. Specifically, transdermal administration of this patch into diet-induced obese mice drastically improved glucose tolerance and insulin sensitivity and alleviated metabolic derangements associated with MAFLD. Furthermore, we uncovered a distinct molecular mechanism underlying the anti-obesity effects associated with the hepatic NLR family pyrin domain-containing 3 (NLRP3) inflammasome and autophagic clearance by the vera@CLCMP hydrogel patches.

Conclusion
The current study provides promising drug delivery platforms for long-term family treatment of chronic diseases, including obesity and metabolic dysfunctions.
The interdependency of border bureaucracies and mobility intermediaries: a street-level view of migration infrastructuring
Authors: Infantino Federica 
Published: January 2023

AbstractBuilding on the case of visa procedures, this article analyses the relationship between border bureaucracies and intermediaries understood as actors, organisations and knowledge that facilitate, shape, and enable human mobility. I take the street-level view to shed light on the interplay of multiple dimensions and logics, which affects how people are mobile. I argue that the analytical lens of interdependency between dimensions and logics that characterize bureaucracies and intermediaries makes sense of migration infrastructuring processes at the street-level. The case of visa policies and practices, which are characterized by the twofold objective of stemming and spurring mobility, is particularly apt to put forward that intermediaries’ socio-economic activities, which bridge borders, by facilitating, shaping, and sustaining mobility, respond not just to the policies and practices that build and reinforce borders but also to those soliciting certain kinds of mobility. The analysis builds on the comparison of ethnographic literature to put forward three empirical situations that exemplify the dynamics of interdependency: Local guides and experts who develop in response to the opacity of bureaucratic procedures and to the distance between visa applicants and state actors; The providers of pieces of documentation, whether counterfeit or ‘real-but-fake’, who respond to the impossibility of complying with bureaucratic requirements and to restrictive border regimes; Authorized administrative agencies, tour operators, travel agencies, and agencies that facilitate the supplying of specific kinds of workforce, who respond to the objective of soliciting the mobility of tourists, businessmen and workers. The street-level view of migration infrastructuring processes connects the micro-perspective of the trajectory of individuals to macro structures such as policies and drivers of international mobility. The investigation of the effectiveness of these actors and activities in obtaining visas, on which further research could systematically focus, shows that they might produce immobility as well. In a nutshell, (im)mobility also results from the interplay between border bureaucracies and mobility intermediaries.
Effect of atracurium and rocuronium on the state and response entropy during isoflurane anesthesia: randomized prospective study
Authors: Hassanien Noran Essam Mohamed , Bassiouny Mohsen Abdghany , ElSerwi Heba Bahaa Eldin , Ashour Tarek Mohamed Ahmed , Ismaiel Mohamed Abdelmohsen Abdelnaiem 
Published: January 2023

Abstract
Background
Several researches have examined the impact of inhalation anesthetics, intravenous anesthetics, and muscle relaxants on spectral entropy, but many did not evaluate the extent of neuromuscular block. Besides, they did not inspect the impact of distinct degrees of neuromuscular blockade on spectral entropy under dissimilar saturations of isoflurane inhalation. Hence, this study has evaluated variant degrees of minimum alveolar concentration (MAC) to estimate the isoflurane concentration, along with various levels of neuromuscular blockade.
This study aims to evaluate the effect of muscle relaxants (atracurium and rocuronium) on entropy readings (state, response entropy, and response-state difference) during isoflurane anesthesia.
This is a prospective randomized study, as forty patients have been included and divided into two study groups: patients in group A received atracurium, while patients in group R received rocuronium. Under 50% and 100% neuromuscular blockage, state and response entropy were observed at MACs of 0.8% and 1%, respectively.

Results
There was a positive correlation between state (SE) and response entropy (RE) at baseline, different MACs, and different trains of four (TOF) for both atracurium and rocuronium. State and response entropy decreased with increasing MAC of isoflurane (P < 0.001), while atracurium and rocuronium at TOF 50% and 100% showed no effect on SE, RE, or RE-SE (P > 0.05).

Conclusions
State and response entropy can be used effectively to evaluate the depth of anesthesia at different isoflurane MAC and atracurium or rocuronium doses.

Registration number
ClinicalTrials.gov identifier: NCT 05097508, Registered October 5, 2021 (prospectively registered), http://www.ClinicalTrial.gov
Novel MTO1 mutations associated with an intrafamilial phenotypic variability
Authors: Almeida Catarina Maria , Rodrigues Esmeralda , Campos Teresa Almeida , Vilarinho Laura , Teles Elisa Leão 
Published: January 2023

Abstract
Background
Mitochondrial diseases are a group of rare inborn metabolic disorders with multi-systemic manifestations. MTO1 gene mutations are associated with MTO1 (Mitochondrial tRNA Translation Optimization 1) protein deficiency, a mitochondrial disorder, which commonly presents with lactic acidosis and hypertrophic cardiomyopathy.

Case presentation
The authors describe two siblings with mitochondrial cytopathy and distinct outcomes. The index case, a female born in 1989, presented hypotonia and lactic acidosis since birth. She developed a severe myoclonic encephalopathy, movement disorder and psychomotor and growth delay. Respiratory chain enzyme complex measurement in muscle revealed a partial deficiency of complex III and IV. Throughout the years she had multiple decompensations with severe acidemia and died at age of 16, due to a respiratory infection. She never presented cardiac alterations. The younger sibling, a male born in 2002, had a less severe clinical presentation. He presented hypotonia and lactic acidosis at birth. Metabolic study performed in the first days of life revealed elevated plasma alanine and hyperlactacidemia. At 8 months of age a partial deficiency of complex IV was reported. He had a mild persistent hyperlactacidemia, psychomotor development delay, generalized hypotonia, dilated cardiomyopathy and epilepsy. In 2017, at 15 years of age, a genetic study confirmed the mitochondrial disease with identification of two MTO1 likely pathogenic variants [c.413delT (p.M138Sfs*6) / c.1450C > T (p.R484W)]. Currently, he is clinically stable, maintaining a multidisciplinary follow up. The same genotype was confirmed in his sister’s stored DNA.

Conclusions
With this case, report the authors emphasize mitochondrial diseases' phenotypic heterogeneity, even in the same family, and the significance of the new genetic diagnostic techniques. The authors also report a novel MTO1 likely pathogenic variant not described to date.
Huge right ventricular myxoma in a 15-year-old female patient: a case report and literature review
Authors: Deebis Ahmed , Elattar Hala , Bakry Ahmed 
Published: January 2023

Abstract
Background
Myxomas represent about 5–10% of primary cardiac tumors in children, and only about 2.5–4% of cardiac myxomas originate from ventricular chambers. Symptoms and signs of right ventricular tumors depend mainly on the size and the site of the tumor and its effect on the inflow and outflow of the blood.

Case presentation
A 15-year-old female patient presented with syncope on exertion and symptoms and signs of congestive heart failure. She had a history of dyspnea and palpitation on exertion for 2 years before admission. Echocardiography and cardiac magnetic resonance imaging (MRI) diagnose a huge right ventricular mobile mass (9 × 4.6 × 3.7 cm) prolapsing during systole into the main pulmonary artery and severe tricuspid regurgitation. The mass showed no contrast enhancement in early dynamic and delayed gadolinium images, suggestive of a thrombus. The mass was safely excised and tricuspid annuloplasty repair was done using right atriotomy and vertical right ventriculotomy approaches. The patient was discharged in a well condition on postoperative day 6. Pathologically, the mass was confirmed as cardiac myxoma with old extensive hemorrhage inside.

Conclusions
Early echocardiography is essential for patients complaining of unexplained cardiac symptoms for early diagnosis and management of rare cases. Multimodality imaging is needed for the diagnosis and planning of the surgical procedure of right ventricular masses. Hemorrhage inside myxoma may lead to no contrast enhancement of the tumor.
Impact of the HLA Immunopeptidome on Survival of Leukemia Patients After Unrelated Donor Transplantation
Authors: Crivello Pietro , Arrieta-Bolaños Esteban , He Meilun , Wang Tao , Fingerson Stephanie , Gadalla Shahinaz M. , Paczesny Sophie , Marsh Steven G.E. , Lee Stephanie J. , Spellman Stephen R. , Bolon Yung-Tsi , Fleischhauer Katharina 
Published: January 2023

PURPOSE Immunopeptidome divergence between mismatched HLA-DP is a determinant of T-cell alloreactivity and clinical tolerability after fully HLA-A, -B, -C, -DRB1, -DQB1 matched unrelated donor hematopoietic cell transplantation (UD-HCT). Here, we tested this concept in HLA-A, -B, and -C disparities after single class I HLA-mismatched UD-HCT. PATIENTS AND METHODS We studied 2,391 single class I HLA-mismatched and 14,426 fully HLA-matched UD-HCT performed between 2008 and 2018 for acute leukemia or myelodysplastic syndromes. Hierarchical clustering of experimentally determined peptide-binding motifs (PBM) was used as a proxy for immunopeptidome divergence of HLA-A, -B, or -C disparities, allowing us to classify 1,629/2,391 (68.1%) of the HLA-mismatched UD-HCT as PBM-matched or PBM-mismatched. Risks associated with PBM-matching status were assessed by Cox proportional hazards models, with overall survival (OS) as the primary end point. RESULTS Relative to full matches, bidirectional or unidirectional PBM mismatches in graft-versus-host (GVH) direction (PBM-GVH mismatches, 60.7%) were associated with significantly lower OS (hazard ratio [HR], 1.48; P < .0001), while unidirectional PBM mismatches in host-versus-graft direction or PBM matches (PBM-GVH matches, 39.3%) were not (HR, 1.13; P = .1017). PBM-GVH mismatches also had significantly lower OS than PBM-GVH matches in direct comparison (HR, 1.32; P = .0036). The hazards for transplant-related mortality and acute and chronic graft-versus-host disease but not relapse increased stepwise from full HLA matches to single PBM-GVH matches, and single PBM-GVH mismatches. A webtool for PBM-matching of single class I HLA-mismatched donor-recipient pairs was developed. CONCLUSION PBM-GVH mismatches inform mortality risks after single class I HLA-mismatched UD-HCT, suggesting that prospective consideration of directional PBM-matching status might improve outcome. These findings highlight immunopeptidome divergence between mismatched HLA as a driver of clinical tolerability in UD-HCT.
Sartre accusateur de Baudelaire ?
Authors: Louette Jean-François 
Published: January 2023

Résumé
Une esquisse de biographie existentielle ; une esquisse de psychanalyse existentielle ; une esquisse d’éthique existentielle – voilà le Baudelaire de Sartre1. Ce n’est pas le moins du monde une charge contre Les Fleurs du Mal ou Le Spleen de Paris ni une étude des ces œuvres. Mais une thèse s’y trouve posée dès la fin du premier paragraphe : les hommes n’ont jamais que la vie qu’ils méritent, et Baudelaire n’échappe pas à la règle. Sartre n’aurait guère aimé notre époque où tout un chacun se proclame victime. Et il allait à contre-courant du grand mouvement de réhabilitation dont Baudelaire bénéficia depuis la fin du XIXe siècle. Peut-être Sartre fut-il le dernier accusateur de Baudelaire ? Mais en quel sens, au juste ? N’est-ce pas aussi avec lui-même qu’il cherche à régler ses comptes ? Tout en faisant de Baudelaire l’occasion d’une réflexion sur l’histoire littéraire de la poésie aux XIXe et XXe siècles.
Making Room for What We Read
Authors: Stratman Jacob 
Published: January 2023

Abstract
In a world of Google-age information accessibility and Facebook-fueled quick rants, the author is interested in teaching a process of reading poetry that does not include easily accessed “answers” or result in reactionary analysis. By using contemporary poetry in introduction to literature courses, the author invites students to resist any quick way of accessing information about the poem. Instead, using Billy Collins's poem, “Introduction to Poetry,” the author helps students explore slower, maybe more contemplative and welcoming ways to listen to the language of the poems they study. And, along the way, the author invites students to consider the particular intellectual virtues they are cultivating in order to read well. In this essay, the author uses Aimee Nezhukumatathil's poem “Hummingbird Abecedarian,” published through the Academy of American Poets Poem-a-Day project, and a poem the author had only read a couple of times before introducing to a group of second-semester first-year “Introduction to Literature” students, as an illustrative example of how using contemporary poems can deepen students’ reading experiences when there are no academic resources around to save them from taking time to read well.
What the Dickens
Authors: Huggins Sofia Prado , Henderson Kaylee 
Published: January 2023

Abstract
In this essay, the authors discuss how collaborative course design fundamentally reshapes power structures within the classroom, opening traditional texts and canonical authors to generative readings. Through the design of an introductory-level literature course centered around a single celebrity author, Charles Dickens, the co-teachers detail how students came to see authorship as an inherently collaborative act, and through the lens of Foucault's “author function,” how these students came to see themselves as both collaborators and authors. This course, from inception to execution, was a collaborative effort grounded in feminist pedagogy, and as demonstrated by student feedback and the project examples included in the appendix, this pedagogical approach empowered the students to recognize themselves as co-creators of knowledge within a classroom.
Ethnic Loyalty versus Spring Fancy
Authors: Stenberg Josh 
Published: January 2023

Abstract
Hei Ying 黑嬰 (1915–1992) wrote prolifically about the “southern isles,” where he—a Hakka from Sumatra—was born. Written for a sophisticated urban readership in China that was curious about the exotic and erotic Nanyang, Hei Ying's 1930s fiction foregrounds questions of Chinese ethnicity and nation. Ethnicity interacts with gender against sultry and desultory backgrounds, with improper patriotic or sexual tendencies attracting narrative punishment. Drawing on three pieces of his short fiction from the 1930s, this article argues that Hei Ying's theme of sexual temptation in the tropics rehearses European colonial (or Han majority) views of the impulsive, sultry native, an image that is contrasted with Republican Chinese primness. The bourgeois woman awakening to Chinese ethnonationalism and rejecting sensuality in favor of patriotism makes her an ancestor to the sexless heroines of Chinese revolutionary culture, including some Hei Ying would write later. The sensuality of the tropics thus operates as a foil for passions correctly channeled—toward nation (and eventually also party-state).
Scribble and E-cadherin cooperate to control symmetric daughter cell positioning by multiple mechanisms
Authors: Chann Anchi S. , Chen Ye , Kinwel Tanja , Humbert Patrick O. , Russell Sarah M. 
Published: January 2023

ABSTRACT
The fate of the two daughter cells is intimately connected to their positioning, which is in turn regulated by cell junction remodelling and orientation of the mitotic spindle. How multiple cues are integrated to dictate the ultimate positioning of daughters is not clear. Here, we identify novel mechanisms of regulation of daughter positioning in single MCF10A cells. The polarity protein, Scribble cooperates with E-cadherin for sequential roles in daughter positioning. First Scribble stabilises E-cadherin at the mitotic cortex as well as the retraction fibres, to mediate spindle orientation. Second, Scribble re-locates to the junction between the two daughters to allow a new E-cadherin-based-interface to form between them, influencing the width of the nascent daughter–daughter junction and subsequent cell positioning. Thus, E-cadherin and Scribble dynamically relocate to different intracellular sites during cell division to orient the mitotic spindle and control placement of the daughter cells after cell division.
This article has an associated First Person interview with the first author of the paper.
Epidemiology of pediatric schistosomiasis in hard-to-reach areas and populations: A scoping review protocol
Authors: Isaiah Phyllis Munyiva , Palmeirim Marta Sólveig , Steinmann Peter 
Published: January 2023

Background: Schistosomiasis is a neglected tropical disease (NTD) that affects millions of people. Children are the most vulnerable group to developing overt disease. An estimated 779 million people are at risk of schistosomiasis and 50 million preschool-age children (PSAC) need treatment. PSAC are not currently targeted by national chemotherapy campaigns due to a lack of suitable pediatric formulations of praziquantel. The Pediatric Praziquantel Consortium has developed an orally dispersible praziquantel formulation (arpraziquantel) and is facilitating its adoption for schistosomiasis control by endemic countries through the ADOPT program – an implementation research program that paves the way for the large-scale delivery of the child-friendly formulation to treat schistosomiasis in preschool-aged children in endemic countries. A key challenge for comprehensive NTD control including schistosomiasis is reaching all at-risk populations, including those hard to reach. Main access barriers include geographic, social and economic conditions. Objective: This scoping literature review aims to document the epidemiology of schistosomiasis in children under 6 years of age living in hard-to-reach areas and populations. Methods: This review will adopt the five-stage scoping review process of identifying the research question, identifying relevant studies, study selection, charting data and collating, summarizing and reporting results. Electronic databases including Medline, Web of Science, Embase (Ovid), LILACS and African Journals OnLine (AJOL) will be searched for relevant articles. Two independent reviewers will screen identified articles using a two-stage approach of reviewing the title/abstract and then the full text of provisionally retained articles. Relevant literatures will be downloaded into EndNote X9 to maintain and manage citation and facilitate the overall review process. A meta-analysis will be conducted if indicated. Relevance: The results will provide insights into the burden of schistosomiasis among marginalized PSAC, aiming to produce evidence on the need for inclusion of this population when designing the expansion of preventive chemotherapy programs.