bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associated Factors of Diabetic Retinopathy by Artificial Intelligence Evaluation of Fundus Images in Japan
Authors: Komatsu Koji , Sano Kei , Fukai Kota , Nakagawa Ryo , Nakagawa Takashi , Tatemichi Masayuki , Nakano Tadashi 
Published: August 2023

Abstract
This cross-sectional study aimed to investigate the promoting and inhibitory factors of diabetic retinopathy (DR) according to diabetes mellitus (DM) stage using standardized evaluation of fundus images by artificial intelligence (AI). A total of 30,167 participants underwent blood and fundus examinations at a health screening facility in Japan (2015–2016). Fundus photographs were screened by the AI software, RetCAD and DR scores (DRSs) were quantified. The presence of DR was determined by setting two cut-off values prioritizing sensitivity or specificity. DM was defined as four stages (no DM: DM0; advanced DM: DM3) based on treatment history and hemoglobin A1c (HbA1c) levels. Associated factors of DR were identified using logistic regression analysis. For cutoff values, multivariate analysis revealed age, sex, systolic blood pressure (SBP), smoking, urinary protein, and HbA1c level as positively associated with the risk of DR among all DM stages. In addition to glycemic control, SBP and Fib-4 might act as promoting factors for DR at all or an earlier DM stage. T-Bil, cholinesterase, and T-cho level might be protective factors at an advanced DM stage.
Psychometric Assessment of the 10-item Experience of Close Relationship- Revised for Adolescents (ECR-R-10-AD)
Authors: Wongpakaran Tinakon , DeMaranville Justin , Wongpakaran Nahathai , Wedding Danny 
Published: August 2023

Abstract
Background:
The Experiences of Close Relationships-revised (ECR-R) is a widely used 36-item self-report measurement for measuring adult as well as child and adolescent attachment. However, some short versions of the ECR-R have been developed and tested psychometrically. Due to cultural differences, respondents from different cultural backgrounds may respond differently to specific items of the ECR-R. This study aimed to develop a new, shorter version of the Thai version of 18-item ECR-R used in Thai adolescents to make it feasible to use and to improve psychometric properties.
Methods:
This study included 433 adolescents, aged between 13-17 years old. Participants completed the 18-item ECR-R, Rosenberg Self-Esteem Scale, Perceived Stress Scale, and Relationship Questionnaire. Exploratory factor analysis was performed to determine the suitable number of items for a new scale. A correlation between the ECR-R-18 and the new scale was carried out. Additionally, correlations between the ECR-R-18, the new scale, and other measurements were also analyzed. The Cronbach alphas and corrected correlations between the anxiety and avoidance subscales of the old and new ECR-R were calculated. Confirmatory factor analysis of the first-order two-factor solution model with fit statistics was examined. Multigroup CFA was performed to investigate measurement invariance.
Results:
he new scale with 10 items, called “ECR-R-10-AD” was developed with good Cronbach’s alpha values of 0.859 and 0.824 for avoidance and anxiety subscale, respectively. The corrected correlation between the ECR-R-18 and ECR-R-10-AD was between .76 (p < .001) and .78 (p < .001). The data fitted the first order two factor solution model well indicating by the values of the comparative fit index (0.968) and Tucker-Lewis index 0.957) for the model, whereas the root-mean-square error of approximation was 0.063 (90%CI, 0.048-0.079), and standardized root mean square residual was 0.046, indicating that the model fits were excellent. The ECR-R-10-AD was shown to have convergent validity with other measurements. The ECR-R-AD seemed to be superior to the ECR-R-18 regarding criterion validity. Measurement invariance was successfully established across different sexes.
Conclusion:
The ECR-R-10-AD provided sufficient psychometric properties among Thai adolescents. Factorial validity, convergent validity and measurement invariance were established. As the ECR-R-10-AD is brief, it can be administered with less burden. Limitation and future research were discussed.
Distribution of bla OXA-10 , bla PER-1 , and bla SHV genes in ESBL-producing Pseudomonas aeruginosa strains isolated from burn patients
Authors: Polse Reem Foad , Khalid Haval M. , Mero Wijdan M. S. 
Published: August 2023

Abstract
Pseudomonas aeruginosa is resistant to a wide range of extended spectrum-lactamases (ESBLs) antibiotics because it produces several kinds of ESBLs. The goal of the current investigation was to identify the bacteria that produce extended spectrum -lactamases and the genes that encode three different ESBLs, such as blaOXA−10, blaPER−1 and blaSHV genes in Pseudomonas aeruginosa isolated from burn patients. In this investigation, 71 Pseudomonas aeruginosa isolates were isolated from burn wounds in Burn and Plastic Surgery Hospital, Duhok City between July 2021 to June 2022. For the purpose of finding the blaOXA−10, blaPER−1, and blaSHV ESBL expressing genes, Polymerase Chain Reaction (PCR) was used. Among 71 Pseudomonas aeruginosa isolates, 26.36% (29/71) were isolated from males and 38.18% (42/71) from females, and 76.06% (54/71) of the isolates were multidrug resistant. They exhibited higher resistance against Piperacillin with resistance rates of 98.59%. Among the ESBL-producing isolates tested, blaOXA−10 was found in 59.26% (32), blaPER−1 was found in 44.44% (24), and blaSHV was found in 11.11% (6). All isolates must undergo antimicrobial susceptibility testing because only a few numbers of the available antibiotics are effective for the treatment of this bacterium. This will prevent the development of resistance in burn units and aids in the management of the treatment plan.
The Role of Preoperative Aspartate Aminotransferase-to-Platelet Ratio Index in Predicting Complications Following Total Hip Arthroplasty
Authors: McLellan Maddison , Donnelly Megan , Callan Kylie , Lung Bradon , Liu Steve , Giovanni Ryan Di , McMaster William , Stitzlein Russell , Yang Steven 
Published: August 2023

Abstract
Background
The purpose of this study was to investigate the relationship between preoperative aspartate aminotransferase-to-platelet ratio index (APRI) and postoperative complications following total hip arthroplasty (THA).
Methods
All THA for osteoarthritis patients from 2007 to 2020 within the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) database were included in this study. Subjects were subsequently divided into cohorts based on APRI. Four groups, including normal range, some liver damage, significant fibrosis, and cirrhosis groups, were created. Comparisons between groups were made for demographics, past medical history, and rate of major and minor complications. Other outcomes included readmission, reoperation, discharge destination, mortality, periprosthetic fracture, and postoperative hip dislocation. Multivariate logistic regression analysis was performed to determine the role of preoperative APRI in predicting adverse outcomes. Statistical significance was set at p < 0.05.
Results
In total, 104,633 primary THA patients were included in this study. Of these, 103,678 (99.1%) were in the normal APRI group, 444 (0.4%) had some liver damage, 256 (0.2%) had significant fibrosis, and 253 (0.2%) had cirrhosis. When controlling for demographics and relevant past medical history, the abnormal APRI groups had a significantly higher likelihood of major complication, minor complication, intraoperative or postoperative bleeding requiring transfusion, readmission, and non-home discharge (all p < 0.05) compared to normal APRI individuals.
Conclusions
Abnormal preoperative APRI is linked with an increasing number of adverse outcomes following THA for osteoarthritis for patients across the United States.
Level of Evidence:
Level I
Facial three-dimensional surface imaging: reliability and validity of handheld structured light scanners and a static stereophotogrammetry system
Authors: Schipper J.A.M. , Merema B.J. , Hollander M.H.J. , Spijkervet F.K.L. , Dijkstra P.U. , Jansma J. , Schepers R. H. , Kraeima J. 
Published: August 2023

Abstract
Introduction
Several new systems of three-dimensional (3D) surface imaging of the face have become available to assess changes following orthognathic or facial surgery. Before they can be implemented into practice their reliability and validity must be established. Our aim was therefore to study 3dMD (stereophotogrammetry), Artec Eva and Artec Space Spider (both structured light scanners) regarding intra- and inter-system reliability and validity.
Material and Methods
Intra- and inter-system reliability expressed in root mean square (RMS) distance was determined by scanning multiple times a mannequin’s head and faces of healthy volunteers. Validity was determined by comparing linear measurements of scans with known distances of a 3D printed model. Post-processing errors were calculated.
Results
Intra-system reliability of mannequin’s head was best for the Artec Space Spider (0.04 mm Spider; 0.07 mm 3dMD; 0.08 mm Eva;). Inter-system reliability of the mannequin’s head showed least differences between Artec Space Spider and Artec Eva. Intra-system reliability of human subjects was best for the Artec Space Spider (0.15 mm Spider; 0.20 mm Eva; 0.23 mm 3dMD). Inter-system reliability of human subjects showed least differences between Artec Eva and Artec Space Spider. Validity of linear measurements was most accurate in the Artec Space Spider. Post-processing error was 0.01mm for all systems.
Conclusion
The Artec Space Spider was the most reliable and valid scanning system.
Continuous adductor canal block reduces opioid consumption, hospital length of stay, and non-home discharge disposition following total knee arthroplasty compared to epidural anesthesia
Authors: Freedman Isaac G. , Mercier Michael R. , Galivanche Anoop R. , Sandhu Mani Ratnesh S , Hocevar Mark , Moore Harold G. , Grauer Jonathan N. , Rubin Lee E. , Li Jinlei 
Published: August 2023

Abstract
Aims
To compare the efficacy of a postoperative continuous adductor canal block (cACB) with and without a steroid adjuvant to that of epidural analgesia (EA).
Methods
All patients who underwent inpatient, primary total TKA at a single institution between July 2011 and November 2017 were included for retrospective cohort analysis. TKA patients were stratified into one of three analgesia approaches based on the time period of their date of surgery: EA, cACB without steroid adjuvant, and cACB with steroid adjuvant. Hospital length of stay (LOS), discharge disposition, incidence of postoperative adverse events, and total milligram morphine equivalents (MME) requirements were compared between analgesia approaches. Recursive feature elimination (RFE)-optimized multivariable logistic regression was performed to assess the independent effect of analgesia approach on prolonged LOS greater than 3 days (pLOS), non-home discharge, and total and daily MME requirements (tMME and dMME) following TKA.
Results
Of 4,345 patients undergoing TKA, 1,556 (35.83%) received EA, 2,087 (48.03%) received cACB without steroids, and 702 (16.13%) cACB with steroids. On univariate analysis, cACB patients experienced lower rates of pLOS (without steroids: 8.53%; with steroids: 8.40%; EA: 12.66%; p < 0.001), higher rates of discharge to home than EA patients (without steroids: 64.40%; with steroids: 75.07%; EA: 46.14%; p < 0.001), and lower tMME and dMME (without steroids: 318.8 tMME and 89.3 dMME; with steroids: 323.8 tMME and 103.0 dMME; EA: 625.0 tMME and 163.3 dMME; p < 0.001). On multivariable analysis, cACB groups were at a significantly lower odds of experiencing a pLOS compared to EA patients without steroids (OR = 0.64; 95% CI 0.49–0.84; p < 0.001; with steroids: OR = 0.54; 95% CI 0.38–0.76; p < 0.001). cACB groups had significantly lower odds of a non-home discharge when compared to EA patients (without steroids OR = 0.42; 95% CI 0.36–0.48; with steroids: OR 0.22; 95% CI 0.18–0.27). On multivariable analysis, cACB groups required significantly less tMME compared to the EA group (without steroids β=-290 MME; 95% CI: -313 to -268 MME; with steroids: β=-261 MME; 95% CI: -289 to -233 MME) as well as significantly lower dMME (without steroids: β=-66 MME/day; 95% CI -72 to -60 MME/day; p < 0.001; with steroids: β=-48 MME/day; 95% CI -55 to -40 MME/day; p < 0.001).
Conclusion
The current study is the first to simultaneously evaluate the efficacy of EA, cACB without perineural steroids, and cACB with steroids as local anesthetic adjuvants. These findings suggest cACB is significantly associated with greater discharge to home rates, lower rates of pLOS, and lower tMME and dMME consumption.
Level of Evidence:
Level III
Knowledge, attitudes, and practices related to clinical practice guidelines and expert consensus statements and relevant reporting specifications among medical journal editors in China：a cross-sectional survey
Authors: Li Yule , Chen Yaolong , Li Na , Liu Yang , Sun Jing , Zhou Qi , Qian Feng 
Published: August 2023

Abstract

Background
Previous research has shown that the quality of clinical practice guidelines (CPGs) and expert consensus statements in China is suboptimal and uneven. However, little is known about the knowledge, attitudes, and practices(KAP)of medical journal editors related to CPGs and expert consensus statements and relevant reporting specifications. This study was intended to Investigate the KAP of medical journal editors, to identify the existing problems, and to explore possible solutions.
Methods
An observational study, using a cross-sectional survey, was distributed to medical journal editors in China, during April–July 2022. The study was collected using a self-designed questionnaire about the KAP of medical journal editors related to CPGs and expert consensus statements and relevant reporting specifications. The details about the participants as well as characteristics, knowledge, experiences, and attitudes were recorded. Descriptive statistics were used as appropriate.
Results
A total of 362 participants completed the survey. The majority (71.5%) had high educational attainment. The level of KAP related to the report contents of CPGs and expert consensus statements among the participants was low and limited. Of all the participants, 59.4% responded they were strongly unfamiliar with the RIGHT statement, 49.5% responded they were strongly unfamiliar with AGREE Ⅱ. There was no significant difference between different gender, age, professional title and position (all p ＞0.05). Similarly, there was no significant difference in the cognition of editors from different editorial departments and sponsors (all p ＞0.05). Medical journal editors thought that the main influencing factors of the reporting quality of CPGs and expert consensus statements were developing quality (90.6%), writing quality (85.9%), editing quality (75.4%) and reviewing quality (57.4%).
Conclusions
The KAP of medical journal editors related to CPGs and expert consensus statements and relevant reporting specifications in China are limited, low, and unsatisfactory, respectively at present. Factors influencing the reporting quality of CPGs and expert consensus statements were identified in the study. These findings help to develop strategies to improve the reporting quality of CPGs and expert consensus statements, and also provide evidence for the training of medical journal editors in the future.
Invasive alien plant species and their effect on the occurrence of mammal species in Shuklaphanta National Park, Nepal
Authors: Chand Chandra , Sharma Hari 
Published: August 2023

Abstract
The introduction and colonization of invasive alien plant species (IAPS) is one of the major threats to the conservation of native flora and fauna. These species are noticed within several protected areas, including lowlands of Nepal, causing adverse effects on both the species and ecosystem services. The effects of IAPS on threatened mammalian species, especially with regards to their occurrences, remains little known. We identified the effects of IAPS on the occurrence of threatened mammalian species at Shuklaphanta National Park (ShNP), Nepal from 11 November 2020 to 11 June 2021. We categorized ShNP into IAPS invaded and non-invaded habitat. We recorded the occurrence of threatened mammal species from 210 plots of 10 m X 10 m along the line transect. Altogether, we recorded 11 invasive alien plant species. Among them blue billygoat weed (Ageratum houstonianum) had the highest abundance in the study area. We recorded 25 mammal species in the study area, whereas 11 were threatened. Among the threatened species, 10 were found in the habitats invaded by IAPS, while all 11 were identified in non-invaded habitats. We found the higher occurrence of threatened mammal species closer to the forest where the abundance of IAPS was observed to decrease. In addition, we observed the occurrence of mammal species increased as the distance from the water source, road, human settlement, and agricultural land increased, indicating that the abundance of IAPS also decreased with increasing distance to water source, road, human settlement and agricultural land. Our findings suggest that the threatened mammal species tend to utilize the non-invaded habitat of IAPS over the invaded habitats. For developing a more suitable habitat for threatened mammal species, we recommend the removal or control of IAPS from ShNP.
RF Fingerprint Extraction and Device Recognition Algorithm Based on Multi-Scale Fractal Features and APWOA-LSSVM
Authors: Feng Wenjiang , Li Yuan , Wu Chongchong , Zhang Juntao 
Published: August 2023

Abstract
RF fingerprints can be used for device identification and network access authentication. An RF fingerprint extraction and device identification algorithm based on multi-scale fractal features and APWOA-LSSVM is proposed. First, a Hilbert transform is performed on the original RF signal, and differential operations are performed on the I/Q signal. Then, the variational modal decomposition is performed on the differentially processed I/Q signals separately to obtain a number of band-limited Intrinsic Modal Function (IMF) components. The fractal box dimension of each IMF component is calculated separately as the first dimensional RF fingerprint. The multi-fractal spectrum of the original RF signal is further computed by Multi-fractal Detrended Fluctuation Analysis (MFDFA) as the second dimensional RF fingerprint. The RF fingerprint feature vector consists of a combination of the first and second dimensional RF fingerprints and is used to train the LSSVM model. Since the penalty factor and kernel parameter width directly affect the recognition accuracy and generalization ability of the LSSVM model, APWOA is used to optimize the hyperparameters of the LSSVM model. Finally, the LSSVM model is constructed using the optimal hyperparameters and the performance of the model is verified on a test dataset. The experimental results show that the proposed model achieves an average recognition accuracy of 99.13% for 16 Bluetooth devices. Multi-scale fractal features consisting of fractal box dimensions and multiple fractal dimensions are more beneficial in the recognition of wireless devices as compared to single features. In addition, the proposed model possesses superior recognition capabilities when compared to classical machine learning algorithms.
Effects of fixed-dose mitiglinide/voglibose combination on vascular endothelial function and glycemic variability in patients with type 2 diabetes: A randomized controlled trial
Authors: Tanaka Kenichi , Okada Yosuke , Umezu Saeko , Hashimoto Ryoma , Tomoyose Yukiko , Tateyama Rina , Hori Yuri , Saito Momo , Tokutsu Akemi , Sonoda Satomi , Uemura Fumi , Kurozumi Akira , Tanaka Yoshiya 
Published: August 2023

Abstract
This multicenter, open-label, randomized, crossover study compared the effects of fixed-dose mitiglinide/voglibose combination tablet with glimepiride on vascular endothelial function and glycemic variability in 30 patients with type 2 diabetes mellitus. Patients received either mitiglinide/voglibose (three times daily administration of 10 mg mitiglinide and 0.2 mg voglibose) or glimepiride (once-daily 2 mg) in random order, for 5 days (n = 15/group). Reactive hyperemia index (RHI) and mean amplitude of glycemic excursions (MAGE) were measured as co-primary endpoints using reactive hyperemia peripheral arterial tonometry and continuous glucose monitoring. Although no significant difference was observed in RHI, MAGE was significantly lower in the mitiglinide/voglibose group (47.6 ± 18.5 mg/dL) than in the glimepiride group (100.6 ± 32.2 mg/dL). Compared to glimepiride, the use of mitiglinide/voglibose was associated with lower standard deviation of mean glucose, coefficient of variation and mean postprandial glucose excursion. Time below range (< 70 mg/dL) and time above range (> 180, > 200, and 250 mg/dL) were lower in the mitiglinide/voglibose group, while time in range (70–180 mg/dL) was higher. Although not impacting vascular endothelial function, mitiglinide/voglibose demonstrated potential benefits in reducing glycemic variability, postprandial hyperglycemia and hypoglycemia in patients with type 2 diabetes.
Correlations of plasma angiopoietin-like 7, fetuin-A levels with coronary heart disease in patients with type 2 diabetes mellitus
Authors: Xue Yashuang , Tian Meimei , Li Min , Jiang Xinli , Cao Jinchao , Zhou Yaru , Liu Yan , Ma huijie 
Published: August 2023

Abstract

Background: The prevalence of coronary heart disease (CHD) is higher in patients with type 2 diabetic mellitus (T2DM), however, relative parameters for evaluating T2DM patients with CHD are quite limited. Circulating angiopoietin-like 7（Angptl7）, fetuin-A（Fet-A） levels have all been found correlated with CHD and T2DM. Therefore, this study aimed to investigate the correlations of plasma Angptl7 and Fet-A levels with the CHD in patients with T2DM.
Methods: T2DM patients were recruited and divided into diabetes without CHD group (T2DM, n=48) and diabetes with CHD group (T2DM+CHD, n=51) according to the history of CHD. Baseline data were collected. Plasma levels of Angptl7 and Fet-A were measured by enzyme-linked immunosorbent assay (ELISA) method.
Results: Compared with that in T2DM patients, plasma Angptl7 levels in patients with T2DM+CHD were significantly increased，while the Fet-A levels and vitamin D levels were significantly decreased (P all<0.05). . Age, plasma level of Angptl7 and Fet-A were influence factors of occurrence of CHD in T2DM patients. Angptl7 and Fet-A possessed diagnostic value for T2DM patients with CHD, and the value was even higher when these two factors combined .
Conclusions: Increased plasma Angptl7 and decreased plasma Fet-A levels are all linked with CHD in T2DM. The combination of Fet-A and Angptl7 possess better diagnostic value for CHD. Therefore, plasma Angptl7 and Fet-A might be promising for diagnosis of CHD in T2DM.