bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary inflammatory index and cardiovascular disease risk in Hispanic women from the Women’s Health Initiative
Authors: Zuercher Monica D. , Harvey Danielle J. , Santiago-Torres Margarita , Au Lauren E. , Shivappa Nitin , Shadyab Aladdin H. , Allison Matthew , Snetselaar Linda , Liu Buyun , Robbins John A. , Hébert James R. , Garcia Lorena 
Published: January 2023

Abstract
Background
To evaluate the association between the dietary inflammatory index (DII®) and incident cardiovascular disease (CVD) in Hispanic women from the Women’s Health Initiative (WHI), and to determine if body mass index (BMI) interacted with the DII scores.

Methods
Secondary analysis of baseline dietary data and long-term CVD outcomes among 3,469 postmenopausal women who self-identified as Hispanic enrolled in WHI. DII scores were calculated from self-administered food frequency questionnaires. The CVD outcomes included coronary heart disease (CHD) and stroke. Stratified Cox regression models were used to assess the relationship between DII scores and CVD in women with and without obesity. Models were adjusted for age, lifestyle risk factors, known risk factors, and neighborhood socioeconomic status.

Results
The incidence of CHD was 3.4 and 2.8% for stroke after a median follow-up of 12.9 years. None of the DIIs were associated with CVD risk in this sample of Hispanic women. BMI interacted with the DII (p < 0.20) and stratified models showed that the associations between the DII and CVD were only significant in women with overweight (p < 0.05). In this group, higher DII scores were associated with a higher risk of CHD (HR 1.27; 95% CI: 1.08, 1.51) and a higher risk of stroke (HR 1.32; 95% CI: 1.07, 1.64).

Conclusion
Among postmenopausal Hispanic women with overweight, greater adherence to pro-inflammatory diets was associated with higher risk of CVD. Additional research is needed to understand how to promote long-term heart-healthy dietary habits to reduce inflammation and prevent CVD in at-risk Hispanic women.
Two-dimensional code enables visibly mapping herbal medicine chemome: an application in Ganoderma lucidum
Authors: Wang Qian , Liu Wenjing , Peng Bo , Gong Xingcheng , Shi Jingjing , Zhang Ke , Li Bo , Tu Pengfei , Li Jun , Jiang Jun , Zhao Yunfang , Song Yuelin 
Published: January 2023

AbstractBackgroundChemical profile provides the pronounced evidence for herbal medicine (HM) authentication; however, the chemome is extremely sophisticated. Fortunately, two-dimensional (2D) code, as a quick response means, is conceptually able to store abundant information, exactly fulfilling the chemical information storage demands of HMs.MethodsWe here attempted to denote both MS$$^1$$1and MS$$^2$$2dataset of HM with a single 2D-code chart. Measurement ofGanoderma lucidumthat is one of the most famous HMs with LC–MS/MS was employed to illustrate the “coding-decoding” workflow for the conversion amongst MS/MS dataset, 2D-code, and chemical profile, and to evaluate the applicability as well. After data acquisition, andm/zvalue of each deprotonated molecular signal was divided into integer and decimal portions, corresponding toxandycoordinates of 2D-plot, respectively. On the other side,m/zvalues of all its fragment ions were exactly assigned to serialxvalues sharing an identicalyvalue being equal to the precursor ion. 2D-code was thereafter produced by plotting these defined dots at a 2D-chart. Regarding a given 2D-code map, the entire chart (xcoordinate: 0–600;ycoordinate: 0–600) was fragmented into two regions by the line of y=x. MS$$^1$$1spectral signals always located below the line, whereas all fragment ions lay at the left zone. After extracting information from the edges of each square frame,m/zvalues of both precursor ion and fragment ions could be harvested and putatively deciphered to a compound through applying some empirical mass fragmentation rules.ResultsThe entire code ofGanoderma lucidumfruit bodies therefore corresponded exactly to a compound set. The elution program, even the employment of direct infusion, couldn’t significantly impact the code, and dramatical differences occurred between different species and amongst different parts ofGanoderma lucidumas well. Not only ganoderic acid cluster but also certain primary metabolites served as the diagnostic compounds towards species differentiation.Conclusion2D-code might be a meaningful, practical visual way for rapid HM recognition because it is convenient to achieve the conversion amongst MS/MS dataset, 2D-barcode plot, and the chemome.
The role of microtubules in microalgae: promotion of lipid accumulation and extraction
Authors: Zhang Lijie , Lin Xiao , Yang Zhigang , Jiang Liqun , Hou Qingjie , Xie Zhen , Li Yizhen , Pei Haiyan 
Published: January 2023

Abstract
Background
Microtubules in cells are closely related to the growth and metabolism of microalgae. To date, the study of microalgal microtubules has mainly concentrated on revealing the relationship between microtubule depolymerization and synthesis of precursors for flagellar regeneration. While information on the link between microtubule depolymerization and biosynthesis of precursors for complex organic matter (such as lipid, carbohydrate and protein), is still lacking, a better understanding of this could help to achieve a breakthrough in lipid regulation. With the aim of testing the assumption that microtubule disruption could regulate carbon precursors and redirect carbon flow to promote lipid accumulation, Chlorella sorokiniana SDEC-18 was pretreated with different concentrations of oryzalin.

Results
Strikingly, microalgae that were pretreated with 1.5 mM oryzalin accumulated lipid contents of 41.06%, which was attributed to carbon redistribution induced by microtubule destruction. To promote the growth of microalgae, two-stage cultivation involving microtubule destruction was employed, which resulted in the lipid productivity being 1.44 times higher than that for microalgae with routine single-stage cultivation, as well as yielding a desirable biodiesel quality following from increases in monounsaturated fatty acid (MUFA) content. Furthermore, full extraction of lipid was achieved after only a single extraction step, because microtubule destruction caused removal of cellulose synthase and thereby blocked cellulose biosynthesis.

Conclusions
This study provides an important advance towards observation of microtubules in microalgae through immunocolloidal gold techniques combined with TEM. Moreover, the observation of efficient lipid accumulation and increased cell fragility engendered by microtubule destruction has expanded our knowledge of metabolic regulation by microtubules. Finally, two-stage cultivation involving microtubule destruction has established ideal growth, coupling enhanced lipid accumulation and efficient oil extraction; thus gaining advances in both applied and fundamental research in algal biodiesel production.
Interactions between the gut micro-community and transcriptome of Culex pipiens pallens under low-temperature stress
Authors: Lv Wen-Xiang , Cheng Peng , Lei Jing-Jing , Peng Hui , Zang Chuan-Hui , Lou Zi-Wei , Liu Hong-Mei , Guo Xiu-Xia , Wang Hai-Yang , Wang Hai-Fang , Zhang Chong-Xing , Liu Li-Juan , Gong Mao-Qing 
Published: January 2023

Abstract
Background
Culex pipiens pallens (Diptera: Culicidae) can survive at low temperature for long periods. Understanding the effects of low-temperature stress on the gut microflora and gene expression levels in Cx. pipiens pallens, as well as their correlation, will contribute to the study of the overwintering mechanism of Cx. pipiens pallens.

Methods
The gut bacteria were removed by antibiotic treatment, and the survival of Cx. pipiens pallens under low-temperature stress was observed and compared with the control group. Then, full-length 16S rRNA sequencing and the Illumina HiSeq X Ten sequencing platform were used to evaluate the gut microflora and gene expression levels in Cx. pipiens pallens under low-temperature stress.

Results
Under the low-temperature stress of 7 °C, the median survival time of Cx. pipiens pallens in the antibiotic treatment group was significantly shortened by approximately 70% compared to that in the control group. The species diversity index (Shannon, Simpson, Ace, Chao1) of Cx. pipiens pallens decreased under low-temperature stress (7 °C). Non-metric multidimensional scaling (NMDS) analysis divided all the gut samples into two groups: control group and treatment group. Pseudomonas was the dominant taxon identified in the control group, followed by Elizabethkingia and Dyadobacter; in the treatment group, Pseudomonas was the dominant taxon, followed by Aeromonas and Comamonas. Of the 2417 differentially expressed genes (DEGs), 1316 were upregulated, and 1101 were downregulated. Functional GO terms were enriched in 23 biological processes, 20 cellular components and 21 molecular functions. KEGG annotation results showed that most of these genes were related to energy metabolism-related pathways. The results of Pearson’s correlation analysis showed a significant correlation between the gut microcommunity at the genus level and several DEGs.

Conclusions
These results suggest that the mechanism of adaptation of Cx. pipiens pallens to low-temperature stress may be the result of interactions between the gut bacterial community and transcriptome.

Graphical Abstract
Stripe-Transformer: deep stripe feature learning for music source separation
Authors: Qian Jiale , Liu Xinlu , Yu Yi , Li Wei 
Published: January 2023

AbstractMusic source separation (MSS) is to isolate musical instrument signals from the given music mixture. Stripes widely exist in music spectrograms, which potentially indicate high-level music information. For example, a vertical stripe indicates a drum time and a horizontal stripe indicates a harmonic component such as a singing voice. These stripe features actually affect the performance of MSS systems, which has not been explicitly explored by previous MSS studies. In this paper, we propose stripe-Transformer, a deep stripe feature learning method for MSS with a Transformer-based architecture. Stripe-wise self-attention mechanism is designed to capture global dependencies along the time and frequency axis in music spectrograms. Experimental results on the Musdb18 dataset show that our proposed model reaches an average source-to-distortion (SDR) of 6.71dB on four target sources, achieving state-of-the-art performance with fewer parameters. And the visualization results show the capability of the proposed model to extract beat and harmonic structure in music signals.
Toward a sustainable growth path in Arab economies: an extension of classical growth model
Authors: Taha Amjad , Aydin Mucahit , Lasisi Taiwo Temitope , Bekun Festus Victor , Sethi Narayan 
Published: January 2023

Abstract
Background/Objectives
Many economies are on the trajectory of alternative growth drivers other than conventional capital and labor. Access to credit facilities is a pertinent indicator of economic growth. In line with the United Nations Sustainable Development Goals (UNSDGs-8) agenda, the national goal for sustainable development for most economies and Arab economies is no exception. Therefore, the current study adopts a traditional growth model by exploring the relationship between gross domestic product (GDP) per capita, credit for private sectors, ratio of exports, real GDP, and per labor force participants for selected Arab economies annually from 2001 to 2020.

Research design
This study leverages the Fourier Kwiatkowski–Phillips–Schmidt–Shin (KPSS) unit root test and second-generation panel econometrics as estimation techniques, such as Westerlund and Edgerton panel cointegration test, and the use of two estimators, namely the augmented mean group (AMG) and common correlated error mean group (CCEMG), to obtain robust results.

Findings
Empirical findings from Westerlund and Edgerton panel cointegration tests validate the long-run equilibrium relationship among the outlined variables. Further empirical results indicate that the share of exports is negatively significant with economic growth in countries such as Kuwait, Lebanon, Tunisia, and Jordan. Additionally, savings and labor force participation have a positive relationship with economic growth in individual countries such as Algeria and Bahrain. As per the panel, there is no significant relationship between labor force participation and economic growth. This indicates that the skilled labor force enhanced economic growth.

Conclusions
These findings come with inherent far-reaching policy suggestions for economies and panels. Further details on country-specific policy actions are presented in the concluding section.

Graphical Abstract
Assessing the implementation fidelity of HPV self-collection offered by community health workers during home visits (the EMA strategy): a case study in a low-middle-resource setting in Argentina
Authors: Paolino Melisa , Sánchez Antelo Victoria , Cuberli Milca , Curotto Mariana , Le Pera Anabella , Binder Fernando , Mazzadi Juan David , Firmenich Beatriz , Arrossi Silvina 
Published: January 2023

Abstract
Background
In Argentina, HPV  self-collection offered by community health workers was demonstrated to be effective to improve cervical cancer screening uptake. Based on these findings, the EMA strategy was scaled up in nine Argentinian provinces. However, there is no evidence about the degree of fidelity—in relation to the core components proposed by the National Program on Cervical Cancer Prevention—with which this strategy was implemented in the new jurisdictions. We carried out a fidelity evaluation of the EMA strategy scaling-up aimed at evaluating the level of adherence to the core components of the EMA strategy, and how different moderating factors affected the implementation fidelity.

Methods
This descriptive study used a multi-method approach involving quantitative and qualitative evaluations of the implementation fidelity using the Conceptual Framework for Implementation Fidelity. Evaluation of the degree of adherence to the core components of the EMA strategy was carried out through the analysis of a self-administered survey of health promoters, observations, and secondary data from the National Screening Information System. The analysis of moderating factors was carried out through analysis of field notes, and semi-structured interviews with key stakeholders.

Results
Our results showed that the core components with highest fidelity were training, sample handling, and transportation. Regarding the offer of HPV self-collection, we found some adaptations such as locations in which health promoters offered HPV self-collection, and fewer pieces of information provided to women during the offer. In the follow-up and treatment core component, we found a reduced adherence to triage and colposcopy. Some contextual factors had a negative impact on implementation fidelity, such as urban insecurity and the reduction in the number of health promoters that offered HPV self-collection. Moderating factors that contributed to achieve high level of fidelity included a well-defined strategy with clear steps to follow, permanent feedback and high level of engagement among implementers.

Conclusions
Our study shows how the analysis of fidelity and adaptations of HPV self-collection in real-world contexts are key to measure and maximize its effectiveness in low-middle-income settings.
Seismic performance evaluation of steel and GFRP reinforced concrete shear walls at high temperature
Authors: Belay Asfaw , Wondimu Temesgen 
Published: January 2023

AbstractFire-induced structural damage to the seismic performance of reinforced concrete shear walls is critical in the event of a fire-earthquake scenario. However, only few researchers have studied the seismic performance of reinforced concrete shear walls at high temperatures. This study focuses on the seismic performance of fiber reinforced concrete shear walls at high temperatures by using finite element (FE) software, ABAQUS. The experimental test available in a literature on seismic behavior of shear walls exposed to fire and thermal properties of glass fiber reinforced polymer (GFRP) bars were used to validate the FE model and showed good agreement and thus used in the simulation.The FE results showed that exposure of RC shear wall to fire reduced the strength of the wall. The strength of walls at the maximum applied drift of 3.2% with concrete cover thicknesses of 20 mm, 25 mm, and 30 mm was dropped by about 70%, 76%, and 85% of the reference shear wall, respectively. Similarly, the strength of RC walls was reduced by about 80%, 75%, and 68% of the reference shear wall for the duration of fire exposure of 30 min, 60 min, and 120 min, respectively. Additionally, the strength of walls due to one side, two sides, or all sides’ exposure to fire was decreased by about 68%, 56%, and 50% of the reference shear wall, respectively. It can generally be concluded that the fire exposure sides has largely affected the strength of the shear wall compared to the other parameters and GFRP bars were more sensitive to temperature than steel bars.
Psychosis prediction 2.0: why child and adolescent mental health services should be a key focus for schizophrenia and bipolar disorder prevention research
Authors: Kelleher Ian 
Published: January 2023

SummaryExisting approaches to psychosis prediction capture only a small minority of future cases. Recent research shows that specialist child and adolescent mental health services (CAMHS) offer a (previously unrecognised) high-risk and high-capacity approach for psychosis early identification, prediction and, ultimately, prevention.
Cancer Risk Associated With PTEN Pathogenic Variants Identified Using Multigene Hereditary Cancer Panel Testing
Authors: Cummings Shelly , Alfonso Andrew , Hughes Elisha , Kucera Matt , Mabey Brent , Singh Nanda , Eng Charis 
Published: January 2023

PURPOSE PTEN-associated clinical syndromes such as Cowden syndrome (CS) increase cancer risk and have historically been diagnosed based upon phenotypic criteria. Because not all patients clinically diagnosed with CS have PTEN pathogenic variants (PVs), and not all patients with PTEN PVs have been clinically diagnosed with CS, the cancer risk conferred by PTEN PVs calculated from cohorts of patients with clinical diagnoses of CS/CS-like phenotypes may be inaccurate. METHODS We assessed a consecutive cohort of 727,091 individuals tested clinically for hereditary cancer risk, with a multigene panel between September 2013 and February 2022. Multivariable logistic regression models accounting for personal and family cancer history, age, sex, and ancestry were used to quantify disease risks associated with PTEN PVs. RESULTS PTEN PVs were detected in 0.027% (193/727,091) of the study population, and were associated with a high risk of female breast cancer (odds ratio [OR], 7.88; 95% CI, 5.57 to 11.16; P = 2.3 × 10−31), endometrial cancer (OR, 13.51; 95% CI, 8.77 to 20.83; P = 4.2 × 10−32), thyroid cancer (OR, 4.88; 95% CI, 2.64 to 9.01; P = 4.0 × 10−7), and colon polyposis (OR, 31.60; CI, 15.60 to 64.02; P = 9.0 × 10−22). We observed modest evidence suggesting that PTEN PVs may be associated with ovarian cancer risk (OR, 3.77; 95% CI, 1.71 to 8.32; P = 9.9 × 10−4). Among patients with similar personal/family history and ancestry, every 5-year increase in age of diagnosis decreased the likelihood of detecting a PTEN PV by roughly 60%. CONCLUSION We demonstrate that PTEN PVs are associated with significantly increased risk for a range of cancers. Together with the observation that PTEN PV carriers had earlier disease onset relative to otherwise comparable noncarriers, our results may guide screening protocols, inform risk-management strategies, and warrant enhanced surveillance approaches that improve clinical outcomes for PTEN PV carriers, regardless of their clinical presentation.
β-FeOOH Nanospindles as Chloride-Capturing Electrodes for Electrochemical Faradic Deionization of Saline Water
Authors: Zhang Lu , Chong Harry Lye Hin , Moh Pak Yan , Albaqami Munirah D , Tighezza Ammar Mohamed , Qin Chengjin , Ni Xinyi , Cao Jing , Xu Xingtao , Yamauchi Yusuke 
Published: January 2023

Abstract
Electrochemical faradic deionization (EDI), one of the most promising research branches of capacitive deionization (CDI), has demonstrated considerable potential for water desalination and ion removal (particularly at medium to low salinity). However, the associated relatively slow anion-capturing kinetics have limited the practical applications of EDI. Based on several studies, researchers have attributed this slow anion-capturing rate to the sluggish conversion-reaction-induced anion-capturing process (as most anion-capturing electrodes belong to the conversion type). Herein, we report a strategy for accelerating the anion-capturing process to enhance the desalination rate of EDI by utilizing an intercalation-type FeOOH electrode. The chloride-driven EDI system equipped with hollandite-type FeOOH nanospindles is found to present a high desalination rate (up to 4.44 mg g−1 min−1) and desalination capacity (51.77 mg g−1). The current study can inspire the future design of ultrafast EDI systems and bring the EDI technique closer to its practical application.
Imaging in patients with acute dyspnea when cardiac or pulmonary origin is suspected
Authors: Milos Ruxandra-Iulia , Bartha Carmen , Röhrich Sebastian , Heidinger Benedikt H. , Prayer Florian , Beer Lucian , Wassipaul Christian , Kifjak Daria , Watzenboeck Martin L , Pochepnia Svitlana , Prosch Helmut 
Published: January 2023

A wide spectrum of conditions, from life-threatening to non-urgent, can manifest with acute dyspnea, thus presenting major challenges for the treating physician when establishing the diagnosis and severity of the underlying disease. Imaging plays a decisive role in the assessment of acute dyspnea of cardiac and/or pulmonary origin. This article presents an overview of the current imaging modalities used to narrow the differential diagnosis in the assessment of acute dyspnea of cardiac or pulmonary origin. The current indications, findings, accuracy, and limits of each imaging modality are reported. Chest radiography is usually the primary imaging modality applied. There is a low radiation dose associated with this method, and it can assess the presence of fluid in the lung or pleura, consolidations, hyperinflation, pneumothorax, as well as heart enlargement. However, its low sensitivity limits the ability of the chest radiograph to accurately identify the causes of acute dyspnea. CT provides more detailed imaging of the cardiorespiratory system, and therefore, better sensitivity and specificity results, but it is accompanied by higher radiation exposure. Ultrasonography has the advantage of using no radiation, and is fast and feasible as a bedside test and appropriate for the assessment of unstable patients. However, patient-specific factors, such as body habitus, may limit its image quality and interpretability. Advances in knowledge This review provides guidance to the appropriate choice of imaging modalities in the diagnosis of patients with dyspnea of cardiac or pulmonary origin.