bluuebunny/crossref_metadata_2025_split huggingface dataset:
Event‐related potential patterns of selective attention modulated by perceptual load
Authors: Chen Zhuo , Qin Yun , Peng Maoqin , Zhao Wei , Shi Xuqian , Lai Danwei , Yin Erwei , Yan Ye , Yao Dezhong , Liu Tiejun 
Published: February 2023

AbstractIntroductionA high perceptual load can effectively prevent attention from being drawn to irrelevant stimuli; however, the neural pattern underlying this process remains unclear.MethodsThis study adopted a perceptual load paradigm to examine the temporal processes of attentional modulation by incorporating conditions of perceptual load, distractor‐target compatibility, and eccentricity.ResultsThe behavioral results showed that a high perceptual load significantly reduced attentional distraction caused by peripheral distractors. The event‐related potential results further revealed that shorter P2 latencies were observed for peripheral distractors than for central distractors under a high perceptual load and that a suppressed compatibility effect with increasing load was reflected by the P3 component.ConclusionThese findings suggested that (1) P2 and P3 components effectively captured different sides of attentional processing modulated by load (i.e., the filter processing of the object and the overall attentional resource allocation) and (2) response patterns of selective attention modulated by perceptual load were influenced by eccentricity. Our electrophysiological evidence confirmed the behavioral findings, indicating the neural mechanisms of attentional modulation.
Inula viscosa (L.) Aiton Ethanolic Extract Inhibits the Growth of Human AGS and A549 Cancer Cell Lines
Authors: Rechek Habiba , Haouat Ammar , Hamaidia Kaouther , Pinto Diana C. G. A. , Boudiar Tarek , Válega Mónica S. G. A. , Pereira David M. , Pereira Renato B. , Silva Artur M. S. 
Published: February 2023

AbstractThe present study shows the chemical profile and cytotoxic properties of the ethanolic extracts of Inula viscosa from Northeast Algeria. The extract was obtained by maceration using ethanol. Its phenolic profile was determined using ultra‐high‐performance liquid chromatography coupled with a diode array detector and an electrospray mass spectrometer (UHPLC‐DAD‐ESI/MS), which allowed the identification and quantification of 17 compounds, 1,5‐O‐caffeoylquinic acid being the most abundant. The cytotoxic activity was assessed against human gastric cancer (AGS) and human non‐small‐cell lung cancer (A549) cell lines, whereas ethanolic extract elicited nearly 60 % and 40 % viability loss toward AGS and A549 cancer cells, respectively. Results also showed that cell death is caspase‐independent and confirmed the involvement of RIPK1 and the necroptosis pathway in the toxicity induced by the I. viscosa extract. In addition, the ethanolic extract would not provoke morphological traits in the cancer cells. These findings suggest that I. viscosa can be a source of new antiproliferative drugs or used in preparation plant‐derived pharmaceuticals.
Optical Super‐Localisation of Single Nanoparticle Nucleation and Growth in Nanodroplets
Authors: Ciocci Paolo , Valavanis Dimitrios , Meloni Gabriel N. , Lemineur Jean‐François , Unwin Patrick R. , Kanoufi Frédéric 
Published: February 2023

AbstractThe formation of metal nanoparticles (NPs) on surfaces by electrodeposition is of significant interest, particularly with a view to understand the early stages of nucleation and growth. Here, the combination of scanning electrochemical cell microscopy (SECCM) and interference reflection microscopy (IRM) is demonstrated to be a compelling approach for real‐time monitoring of NP dynamics within the SECCM meniscus‐electrode wetted area, through synchronous monitoring in the millisecond range of the electrochemical and optical signatures. Diffraction‐limited entities, undergoing phase changes at the electrode substrate, are readily highlighted and tracked in time, including the onset time for the appearance of NPs and their movement over time. The results strongly implicate the rapid formation, surface diffusion and aggregation of smaller entities (not detectable optically) to produce the larger electrodeposited NPs. By applying SECCM tips of different size, it is also possible to understand how the wetted area (meniscus size) plays a key role in the number of NPs formed, with small tip sizes allowing the formation of single NPs. The SECCM‐IRM approach is expected to be a powerful platform for the study of myriad phase‐formation processes at the nanoscale, particularly by drawing on the possibility of making hundreds or thousands of measurements in fresh surface locations through SECCM technology.
Prozesstechnik auf der ACHEMA 2022
Authors: Mehling Tanja , Kleiber Michael 
Published: February 2023

AbstractDie ACHEMA 2022 war nur etwa halb so groß wie üblich, bildete aber die großen Trends in der Prozesstechnik hinreichend ab. Hervorzuheben sind die Forschungen zur Nutzung von Wasserstoff als Energieträger und die Verwendung von CO2, CO und Polymerabfällen als Rohstoffe. Doch auch neue Entwicklungen bei der Gestaltung von Wärmeübertragern, Mischern und Reaktoren, der Kopplung von Digitalisierung und Verfahrenstechnik und neuen Lösungen zur Energieeffizienz sowie raffinierte Messtechnik und Vorführungen zur Sicherheitstechnik machten die ACHEMA zu einer spannenden Messeveranstaltung.
Nickel/Quinim Enabled Asymmetric Carbamoyl‐Acylation of Unactivated Alkenes
Authors: Wu Xianqing , Li Haiyan , He Feng , Qu Jingping , Chen Yifeng 
Published: February 2023

Comprehensive SummaryTransition metal‐catalyzed difunctionalization of tethered alkene has emerged as a prevailing tool for the expedient construction of synthetically valuable cyclic compounds. However, most efforts have been devoted to the reaction of styrene‐type substrates due to their rigid scaffold and high reactivity. With respect to the difunctionalization of nonaromatic tethered olefin, especially the mono‐substituted alkene, still remains largely underdeveloped. Herein, we disclose a nickel/Quinim complex and TBADT‐cocatalyzed asymmetric carbamoyl‐acylation of unactivated alkene tethered on nonaromatic carbamoyl chlorides with diverse aldehydes. The reaction exhibits broad substrate scope with good functional group tolerance, as well as high reaction efficiency and enantioselectivity. Both monosubstituted and 1,1‐substituted alkenes can work well with either aliphatic or aromatic aldehydes under the current protocol, providing convenient access to an array of medicinally useful chiral γ‐lactams derivatives bearing a convertible acyl functionality. This reaction showcases more application possibilities of the chiral Quinim ligand in the future asymmetric catalytic transformations.
Predictive value of serum iron on heart failure in patients with acute ST‐segment elevation myocardial infarction
Authors: Chen Wen , Lin Guoli , Dai Caizhi , Xu Kaizu 
Published: February 2023

AbstractBackgroundIn clinical practice, heart failure often occurs after acute myocardial infarction, and a new biomarker for its early prediction is urgently needed. The aim of this study was to investigate the relationship between serum iron and heart failure after acute ST‐segment elevation myocardial infarction (STEMI).MethodsA total of 41 patients with heart failure after STEMI and 31 controls were included in the study. The demographic variables and baseline clinical characteristics of both groups were analyzed.ResultsThere were no significant differences between patients with heart failure and controls in terms of demographic characteristics. There were significant differences in terms of serum iron, N terminal pro‐B‐type natriuretic peptide levels, left atrial diameter, and left ventricular ejection fraction. Binary logistic regression analyses demonstrated that serum iron (odds ratio [OR]: 0.804, 95% confidence interval [CI]: 0.699–0.924) and Tn‐I (OR: 1.072, 95% CI: 1.011–1.137) were independent predictors for heart failure (p < .05, respectively). Receiver operating characteristic analysis showed that the area under the curve for serum iron was 0.808 (95% CI: 0.707–0.908, p < .01). The best cutoff value of serum iron was 11.87 μmol/L (sensitivity: 87.1%; specificity: 68.3%).ConclusionsPatients with heart failure after STEMI have lower serum iron levels than patients without heart failure after STEMI. Serum iron levels are a risk factor for heart failure after STEMI.
Evaluation of Pharmacokinetics and Safety With Bioequivalence of Voriconazole Injection of 2 Formulations in Chinese Healthy Volunteers: Bioequivalence Study
Authors: Huang Chunqi , Dong Danqing , Yu Fei , Ren Xueying , Wu Yi , Wang Zhuoyan , Wang Ying 
Published: February 2023

AbstractVoriconazole is a first‐line medicine for treating invasive aspergillosis. We aimed to evaluate the bioequivalence (BE) of voriconazole injection in Chinese healthy volunteers (HVs). In this single‐center, randomized, single‐dose, 2‐cycle, fasting‐dose BE study, HVs (n = 24) were 1:1 divided into 2 groups (test [T]–reference [R] and R–T) and received 6 mg/kg of voriconazole intravenously with a 7‐day washout. The plasma was collected for up to 72 hours at the time point after dosing on day 1/day 8. The plasma concentration of voriconazole was measured by liquid chromatography–tandem mass spectrometry. Pharmacokinetic parameters were ascertained on the basis of a noncompartmental model. In the BE study, the geometric mean ratios of the maximum concentration, area under the concentration–time curve from time 0 to the last measurable plasma concentration, and area under the concentration–time curve from time 0 to infinity were 101.1%, 105.6%, and 105.5%, respectively, and the 90%CI fell within 80%–125%. Adverse events were observed in 26.1% of subjects in the T formulation stage and 17.4% in the R formulation stage. Under the BE study, voriconazole values from T and R formulations were bioequivalent.
Fiber Spinning of Ultrahigh Molecular Weight Isotactic Polypropylene: Melt Spinning and Melt Drawing
Authors: Stieglitz Lucas , Geiger Christina , Großmann Paula F. , Kränzlein Moritz , Rodewald Katia , Müller‐Buschbaum Peter , Rieger Bernhard 
Published: February 2023

AbstractHerein, this work reports fiber spinning of tailored isotactic polypropylene (iPP) by melt spinning and melt drawing, yielding an adjustable diameter of 40–400 μm. The crystallinity of all obtained fibers with a molecular weight between 330–1400 kg/mol is increased by thermal annealing and investigated via differential scanning calorimetry (DSC) as well as wide angle X‐ray scattering (WAXS). The potential of ultrahigh molecular weight iPP (UHMW‐iPP) fibers compared to fibers manufactured from industrially available iPP becomes evident when the mechanical performance is compared: fibers spun from UHMW‐iPP (1400 kg/mol) enable a tensile strength of up to 400 MPa, whereas commercially available fibers (330 kg/mol) show a tensile strength of approximately 50 MPa. However, UHMW‐iPP exhibits a short timeframe, in which extrusion is possible, thereafter extrusion rupture occurs, probably induced by an increased melt viscosity.
Quantification of tumorsphere migration with a physics‐based machine learning method
Authors: Vong Chun Kiet , Wang Alan , Dragunow Mike , Park Thomas I.‐H. , Shim Vickie 
Published: February 2023

AbstractCurrent analysis techniques available for migration assays only provide quantitative measurements for overall migration. However, the potential of regional migration analyses can open further insight into migration patterns and more avenues of experimentation with the same assays. Previously, we developed an analysis pipeline utilizing the finite element (FE) method to show its potential in analyzing glioblastoma (GBM) tumorsphere migration, especially in characterizing regional changes in the migration pattern. This study aims to streamline and further automate the analysis system by integrating the machine‐learning‐based U‐Net segmentation with the FE method. Our U‐Net‐based segmentation achieved a 98% accuracy in segmenting our tumorspheres. From the segmentations, FE models made up of 3D hexahedral elements were generated, and the migration patterns of the tumorspheres were analyzed under treatments B and C (under non‐disclosure agreements). Our results show that our overall migration analysis correlated very strongly (R2 of 0.9611 and 0.9986 for treatments B and C, respectively) with ImageJ's method of migration area analysis, which is the most common method of tumorsphere migration analysis. Additionally, we were able to quantitatively represent the regional migration patterns in our FE models, which the methods purely based on segmentations could not do. Moreover, the new pipeline improved the efficiency and accessibility of the initial pipeline by implementing machine learning‐based automated segmentation onto a mainly open‐sourced FE analysis platform. In conclusion, our algorithm enables the development of a high‐content and high‐throughput in vitro screening platform to elucidate anti‐migratory molecules that may reduce the invasiveness of these malignant tumors.
High survival following bleaching underscores the resilience of a frequently disturbed region of the Great Barrier Reef
Authors: Page Cathie A. , Giuliano Christine , Bay Line K. , Randall Carly J. 
Published: February 2023

AbstractNatural bleaching events provide an opportunity to examine how local‐scale environmental variation influences bleaching severity and recovery. During the 2020 marine heat wave, we documented widespread and severe coral bleaching affecting 75%–98% of coral cover throughout the Keppel Islands in the southern inshore Great Barrier Reef. Acropora, Pocillopora, and Porites were the most severely affected genera, while Montipora was comparatively less susceptible. Site‐specific heat‐exposure metrics were not correlated with Acropora bleaching severity, but recovery was faster at sites that experienced lower heat exposure. Despite severe bleaching and exposure to accumulated heat that often results in coral mortality (degree heating weeks ~4–8), cover remained stable. Approximately 94% of fate‐tracked Acropora millepora colonies survived, perhaps due to reduced irradiance stress from high turbidity, heterotrophic feeding, and large tidal flows that can increase mass transfer. Severe bleaching followed by rapid recovery and the continuing dominance of Acropora populations in the Keppel Islands is indicative of high resilience. These coral communities have survived a 0.8°C increase in average temperatures over the last 150 years. However, recovery following the 2020 bleaching was driven by the easing of thermal stress, which may challenge their recovery potential under further warming.
The association study between changes in HbA1C with rs2250486 and rs67238751 genetic variants for SLC47A1 in newly diagnosed Iranian patients with type 2 diabetes mellitus: 6 months follow‐up study
Authors: Semnani Armina , Kazerouni Faranak , Kalbasi Saeid , Shahrokhi Seyedeh Zahra , Rahimipour Ali 
Published: February 2023

AbstractObjectivesOne of the most well‐known oral medications for the treatment of T2DM is metformin. Variants have been found in studies to be useful in detecting new genes connected to T2DM aetiology and affecting metformin's mechanism of action. In this research, we aimed to study two variations of the SLC47A1 gene; rs2250486 and rs67238751, in T2DM patients who had been taking metformin for the first 6 months after the diagnosis in the Iranian population for the first time.Design and MethodsA total of 200 individuals were recruited for the study. According to their glycosylated haemoglobin (HbA1c) levels, the patients were divided into two groups: responders (HbA1c levels were reduced by at least 1% after 6 months of metformin treatment.) and non‐responders. DNA was extracted from whole blood and genotyped by Tetra ARMS PCR. High‐performance liquid chromatography (HPLC) was used to measure HbA1c levels at the start of the treatment and again 6 months later.Resultsrs2250486 variant in the dominant model reduces the HbA1C levels after 6 months of metformin treatment. In fact, when compared to the T/C + C/C genotypes, the T/T genotype improves HbA1C levels (p‐value = .014). Furthermore, in the allelic model, the T allele improves HbA1C levels in comparison to the C allele (p‐value = .008). After 6 months of metformin treatment, serum levels of HbA1C in responders were reduced significantly in both groups (T/T and T/C + C/C), (p‐value = <.0001). However, the rs67238751 variant did not reveal a meaningful relationship with lower HbA1C levels in any of the models.ConclusionsThis study found that the rs2250486 variant could be associated with reducing HbA1C levels while the rs67238751 variant, had no relationship.
Use of and association between heart failure pharmacological treatments and outcomes in obese versus non‐obese patients with heart failure with reduced ejection fraction: data from the Swedish Heart Failure Registry
Authors: Cappelletto Chiara , Stolfo Davide , Orsini Nicola , Benson Lina , Rodolico Daniele , Rosano Giuseppe M.C. , Dahlström Ulf , Sinagra Gianfranco , Lund Lars H. , Savarese Gianluigi 
Published: February 2023

ABSTRACTAimsTo investigate the use of guideline‐directed medical therapies (GDMT) and associated outcomes in obese (body mass index ≥30 kg/m2) versus non‐obese patients with heart failure (HF) with reduced ejection fraction (HFrEF).Methods and resultsPatients with HFrEF from the Swedish HF Registry were included. Of 16 116 patients, 24% were obese. In obese versus non‐obese patients, use of treatments was 91% versus 86% for renin–angiotensin system inhibitors (RASi)/angiotensin receptor–neprilysin inhibitors (ARNi), 94% versus 91% for beta‐blockers, 53% versus 43% for mineralocorticoid receptor antagonists. Obesity was shown to be independently associated with more likely use of each treatment, triple combination therapy, and the achievement of target dose by multivariable logistic regressions. Multivariable Cox regressions showed use of RASi/ARNi and beta‐blockers being independently associated with lower risk of all‐cause/cardiovascular death regardless of obesity, although, when considering competing risks, a lower risk of cardiovascular death with RASi/ARNi in obese versus non‐obese patients was observed. RASi/ARNi were associated with lower risk of HF hospitalization in obese but not in non‐obese patients, whereas beta‐blockers were not associated with the risk of HF hospitalization regardless of obesity. At the competing risk analysis, RASi/ARNi use was associated with higher risk of HF hospitalization regardless of obesity.ConclusionObese patients were more likely to receive optimal treatments after adjustment for factors affecting tolerability, suggesting that perceived beyond actual tolerance issues limit GDMT implementation. RASi/ARNi and beta‐blockers were associated with lower mortality regardless of obesity, with a greater association between RASi/ARNi and lower cardiovascular death in obese versus non‐obese patients when considering competing risk.
Quality by design‐based capillary electrophoresis method development for the quantitative analysis of four iridoid compounds in Gentiana macrophylla Radix
Authors: Zhang Zhiyong , Zhang Xiaoyang , Li Shunan , Chen Yun , Li Zheng , Lian Yunlan , Li Wenlong 
Published: February 2023

AbstractIn this study, the capillary electrophoresis‐photodiode array detector was employed for the analysis of four iridoid compounds in Gentiana macrophylla Radix (RGM), and the method was optimized based on the concept of analytical quality by design (AQbD). The peak areas relative standard deviation (n = 3) and resolution of the four analytes were selected as critical method attributes. Fractional factorial design test combined with Pareto analysis were employed to screen critical method parameters (buffer concentration, pH, sodium dodecyl sulfate [SDS] micelle concentration, temperature, and voltage). Subsequently, three main factors (buffer concentration, buffer pH, and SDS concentration) were selected by central composite design test for constructing the design space. The optimal separation conditions as follows: capillary column (50.2 cm × 50 µm, detection length 40 cm). Working background electrolyte consisted of 51 mmol/L borax solution (pH = 9.47) and 40 mmol/L SDS. The samples were injected by pressure (5 s at 0.5 psi) and the detection was performed at 254 nm. Applied voltage was 20 kV and column temperature was 23°C. The developed method is rapid and reliable for the quantitative analysis of four iridoid compounds in RGM, providing a reference for the application of AQbD concept in the analysis of natural products.
Online large volume sample staking preconcentration and separation of enantiomeric GHRH analogs by capillary electrophoresis
Authors: Otin Joanie , Tran N. Thuy , Benoit Aurélie , Buisson Corinne , Taverna Myriam 
Published: February 2023

AbstractA capillary electrophoresis method is proposed to analyze the four most well‐known growth hormone–releasing hormone (GHRH) analogs that are misused by athletes. Dimethyl‐β‐cyclodextrin used as a chiral selector allowed, for the first time, the separation of those basic peptide analogs, including enantiopeptides (sermorelin and CJC‐1293) that differ by the chirality of only one amino acid. To increase the method sensitivity, electrokinetic preconcentration methods have been investigated. The large volume sample stacking with polarity switching (PS‐LVSS) method with an injected sample volume corresponding to 80% of the capillary one was found superior to the sweeping in terms of signal enhancement factor (SEF). Acid and organic solvent addition to the sample (0.1 mM phosphoric acid with 30% methanol) led to a twofold signal improvement, when compared to water as a matrix. We increased capillary dimensions to provide a signal enhancement through the injection of a larger sample volume. Finally, using a combination of the optimized PS‐LVSS preconcentration with the chiral capillary zone electrophoresis (CZE), the GHRH analogs were separated and limits of detection between 75 and 200 ng/mL were reached. This method was successfully applied to urine after a desalting step. An optimized C18 SPE was used for that purpose in order to provide low sample conductivity (<130 µS/cm) and preserve the efficiency of LVSS preconcentration. SEF of 640 was obtained with desalted urine spiked with sermorelin by comparison to the CZE (without preconcentration) method.