bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent advances in biological applications of mannich bases — An overview
Authors: Raju Senthil Kumar , Vengadhajalaphathy Priyadharshini , Sundaram Revathy , Periyasamy Sangeetha , Chinnaraj Thatchayani , Sekar Praveen 
Published: April 2023

Mannich bases are beta-amino ketone-carrying compounds that are the end products of the Mannich reaction. The Mannich reaction is essential in the synthesis of nitrogen-containing compounds. The Mannich reaction, a nucleophilic addition reaction that forms carbon-carbon bonds, is employed in the synthesis of numerous natural products, drugs and other compounds. There are several aminoalkyl chain bearing Mannich bases with high curative value, such as fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and many others. According to the literature, Mannich bases are highly reactive and have been demonstrated to have powerful anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal, anticonvulsant, anthelmintic, antitubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral, antilipase activity and other properties. The primary source of, -α,β-unsaturated ketone, which can be produced by deaminating the hydrogen atom of the amine group, is responsible for the biological action of Mannich bases. However, a number of minor biological functions of Mannich bases have been reported, including their ability to control blood pressure or prevent platelet aggregation, their impact on parasites and ulcers, and their use as medications for mental health issues. Since there is a greater need for anticonvulsant pharmaceuticals, these anticonvulsant medications containing N-mannich base groups will exhibit an increase in lipophilic nature and hence have improved blood-brain barrier penetration. The overview concludes with a brief explanation of the potential of Mannich bases as inhibitors of various enzymes or ligands for various receptors.
Pharmacotherapy of small cell lung cancer: Current state-of-the-art
Authors: Berezhnova Tatyana A. , Lunyova Yelena A. , Dyadina Kseniya S. , Borisov Vladimir A. 
Published: April 2023

Introduction: Lung carcinoma is the leading cause of death in men and is closely related to smoking. The article focuses on the current statistics of this pathology in the world.
Materials and methods: The literature review was carried out using PubMed database and included articles published from 2006 to 2021. The current schemes of chemotherapy and diagnostic options of small cell lung cancer were analyzed. The mechanisms of drug action on tumor cells were considered. An analysis of the publication activity in PubMed database related to pharmacotherapy of small cell lung cancer allows reporting a twofold increase in the number of publications over the period from 2007 to 2017.
Results and discussion: A systematic review presenting staging of small cell lung cancer (SCLC) and its radiation diagnostics has been conducted. As demonstrated, there are no current methods with proven effectiveness to early detect this pathology. However, it has been found that annual low-dose CT screenings helped detect a significant number of lung cancer cases at the early stage, although, the proportion of small cell carcinoma is still very high. Analyses of clinical outcomes of small cell lung cancer have showed that cisplatin/etoposide (EP) or carboplatin/etoposide (EC) appear to be the key combinations with high treatment efficacy. The article also discusses chemotherapy for small cell lung cancer, namely and the principle of its effect on tumor cells. However, this chemotherapy remains very toxic and causes a number of life-threatening side effects. It is necessary to assess the effectiveness of chemotherapy immediately after the start of treatment in order to balance benefits and risks.
Conclusion: The search is currently under way for less toxic but effective compounds, this fact being a crucial issue of healthcare in providing high-quality medical and pharmaceutical care for cancer patients. Chemotherapy of the pathology under study requires high costs; therefore, a pharmacoeconomical assessment of the prescription of chemotherapy for small cell lung cancer is necessary to compare the costs of treatment and its effectiveness
Graphical Abstract
Analysis of the frequency of detection of hypercholesterolemia, carotid atherosclerosis and lipid-lowering therapy prescription in young adults under 45 years old according to the Duplex registry database
Authors: Gaisenok Oleg V. 
Published: April 2023

Aim of the study to analyze the detection of hypercholesterolemia (HCHL) and carotid atherosclerosis (CAS), verified by duplex scanning of the carotid arteries (DSCA) in young adults (YA), and to evaluate the lipid-lowering therapy (LLT) prescription among them according to the local registry database.
Material and Methods: The Duplex registry database was used for this study (n=2548). YA up to 45 years old were selected for the final analysis (n=351).
Results: HCHL (> 5 mmol/L) was detected in 68.9% of patients (n=241), and only 9.5% of them received LLT (n=23). CAS was detected in 12.8% (n=45), only 17.8% of them had received LLT (n=8). Men and women differed 1.5 times by the incidence of CAS in this age range: 15.7% (30 out of 191) vs 9.4% (15 out of 160), p=0.05. Men also generally have a higher prevalence of other risk factors/diseases: HCHL (78.0% (n=149) vs 58.1% (n=93) in women, p=0.00004), hypertension (AH) (15.7% (n=30) vs 9.4% (n=15) in women, p=0,05), history of myocardial infarction (MI) (1,6% (n=3) vs 0% (n=0) in women, ns). Signs that had a significant impact on LLT intake were the following: CAS (OR 2.8 [1.09;6.6] p=0.036); AH (OR 3.1 [1.32; 7.16] p=0.009); HCHL (> 5 mmol/L) (OR 4.2 [1.12; 26.83] p=0.06); HCHL (ICD-10 code E78) (OR 5.4 [2.04; 13.7] p=0.0003); MI history (OR 22.3 [1.65;675.5] p=0.009).
Conclusion: The insufficient LLT prescription in young adults with HCHL and CAS was ascertained in the present study. The use of imaging methods to clarify the degree of cardiovascular risk is advisable for low and intermediate risk patients, which include young adults. DSСA is the main method for subclinical atherosclerosis verification. LLT should be prescribed to all YA patients with CAS (in the absence of contraindications).
Graphical Abstract
The endogenic neurosteroid system and its role in the pathogenesis and therapy of mental disorders
Authors: Bairamova Sakeena P. , Petelin Dmitry S. , Akhapkin Roman V. , Kudryashov Nikita V. , Sorokina Olga Yu. , Semin Sergey A. , Panfilova Veronika , Volel Beatrice A. 
Published: April 2023

Introduction: Although neurosteroids have been relatively recently discovered, their significant role in the neurochemical processes and pathogenesis of a number of psychiatric and neurological disorders is now quite clear. First of all, it seems important to clarify the definition of the endogenous neurosteroids as a class of steroids, taking into account the variability of approaches to their description. Currently, neurosteroids include endogenous steroids synthesized in the central nervous system, gonads, or adrenal glands and interacting with GABAA, NMDA, and sigma-1 receptors.
Neurosteroid biosynthesis: Biosynthesis of neurosteroids begins with rate-limiting reaction of TSPO binding cholesterol and transporting it into the mitochondria, where pregnenolone is synthesized following the cytochrome P450scc (CYP11A1) impact.
Interaction with GABAА, NMDA and sigma-1 receptors: According to the experimental data, neurosteroids act as the most highly potent endogenous allosteric modulators of the GABA receptor; some types of neurosteroids (ALLO, DHEA, etc.) can produce a rapid anxiolytic and anticonvulsant effect. There is some experimental evidence for antipsychotic effects of some neurosteroids realized through NMDA receptors: intracerebral administration of ALLO to laboratory animals can prevent further appearance of motor agitation and other equivalents of psychosis after administration of high doses of amphetamines. It has also been proven in several studies on animal models that neurosteroids exhibit anxiolytic effects through sigma-1 receptors.
Conclusion: The article describes the process of neurosteroidogenesis and the effect of neurosteroids on listed receptorsin accordance with already available scientific data. In addition, this paper describes the specific role of various neurosteroids in the development of mental illnesses, including anxiety disorders, depression, and schizophrenia
Graphical Abstract
A cross-cultural study of students’ awareness of natural disasters: voices from KSA, Yemen and Egypt
Authors: Alanazi Fayadh , Khalaf Mustafa Ali , Alzamil Mohammed Saleh , Abdo Noman  
Published: April 2023

In recent years, there has been a remarkable increase in the intensity and frequency of natural disasters.There is no doubt that a thorough knowledge of natural disasters and an adequate awareness of how to protect against their negative consequences will spare many individuals considerable losses. Accordingly, the present study aims to investigate students’ level of awareness of natural disasters within a cross-cultural perspective. Twelve schools in Saudi Arabia, Egypt and Yemen were selected (four schools from each country). The total research sample consisted of 180 sixth and ninth grade students randomly selected from the targeted schools, with 60 students from each country. Semi-structured interviews were implemented. The results indicate that the majority of students in these three countries have a false or complete lack of perception of the phenomena of earthquakes and volcanoes. Only 20.6% of students in these three countries had a completely correct perception of how earthquakes occur. An analysis of students’ drawings of this phenomenon revealed that, on average,only 13.3% were able to clarify the scientific reason for earthquakes; the highest percentage of correct answers came from the students of the Arab Republic of Egypt (15.0%), followed by Saudi students (13.3%) and then Yemeni students (11.7%). Furthermore, it was found that the religious understanding, culture and day-to-day experiences of thelearners in these countries influence their cognizance and analysis of natural events, and that they develop intricate understanding and theories based on their beliefs and experiences.
A Study of the Relationship between Locus of Control and Self-monitoring to Resilience in Students
Authors: Shanava Ina , Gergauli Giorgi 
Published: April 2023

A person may experience both positive and negative stress, which is mainly associated with a wide range of negative consequences, such as a decrease in well-being, an increase in diseases, post-traumatic stress, anxiety, and depression disorders. High stress in a person does not always develop these negative results. According to latest researches and studies, most people are exposed to stress, and developing resilence is the main factor in order to cope with the unpredictable environment (Troy & Mauss, 2011). The ability to disengage from negative stimuli and feelings is an important protective factor against long-term negative results. Resilience represents the ability of a person to cope with life's difficulties and is a multidimensional characteristic which varies by context, age, gender, culture, and individual life (Felicia et al., 2021). According to contemporary approaches, resilience is a personal trait that helps a person to adapt and cope with traumatic experience. Psychological component of resilience means that a person maintains psychological health without any trauma and stressors, .while behavioral component of resilience means maintenance of self-effectiveness and aspiration towards goals (Kamushadze, 2021). One of the components of resilience at the individual level is identified as self-control, which is an aspect of behavior control and is often viewed as willpower and the ability to control impulses. In a psychological sense, self-control refers to emotions and the initiation or modification of emotional reactions through cognitive processes. The locus of control is also considered to be a factor that has a significant influence on the formation of resilience. According to Rotter, people differ from each other according to the localization of control over events. This difference can be described as internal and external poles. Internal people believe that everything that happens in their lives depends only on their personal qualities, purposefulness, abilities, and competence. External people strongly believe that their lives are controlled by outside forces, and their success or failure is the fault of randomness, other people, and so on., This paper therefore focuses on determining the relationship between the locus of control and self-monitoring to resilience among undergraduate, graduate, and doctoral students. Internal-External Locus of Control Scale (I-E Scale), Self – Monitoring Scale, and Brief Resilience Scale (BRS) were used in this study. Based on the analysis of the results, it was revealed that self-ownership is related to resilience and locus of control, and the latter is negatively related to resilience. Differences were analyzed by demographic characteristics.
Impacts de la Contamination Agricole sur la Qualité Physicochimique des Eaux de Surface de l’Ouémé Supérieur au Bénin
Authors: Fassinou Nonvignon Martial , Gouissi Fadéby Modeste , Goura Souradjou Orou , Yessoufou Wakili Bolatito , Biaou Tayéwo Sylvain , Kakpo Kpessou Hopson , Akodogbo Hervé Hotèkpo , Toffa Dagbédji Damien 
Published: April 2023

Le présent travail vise à apprécier la qualité physico-chimique des eaux de l’Ouémé supérieur au Bénin. L’étude concerne quatre (04) communes. Les données ont été collectées en octobre 2021 et en mars 2022. Les paramètres physiques in-situ et les paramètres chimiques au laboratoire ont été étudiés. La description par les box plots (Boîtes à moustaches), le test de Shapiro-Wilk et celui de Kruskall Wallis au seuil α = 5% ont été utilisés. Les paramètres tels la salinité, T°C,〖 NO〗_2^-, NO_3^-, NH_4^+, PO_4^(3-), Ca2+, Mg2+, Fe2+ et le Cl- sont significativement différents des autres paramètres et ne respectent pas les normes des eaux de surface. Les résultats de la Classification Hiérarchique Ascendante (CAH) ont permis d’identifier trois groupes. Le groupe 1, constitué de : pH, OD, Salinité,〖 NO〗_2^-, NO_3^-,〖 NH〗_4^+,〖 PO〗_4^(3-), Ca2+, Mg2+, Fe2+ et le Cl- ; proviennent principalement des activités agricoles et des eaux usées. Le groupe 2, constitué de : T°C, STD et la DCO ; proviennent des différents éléments chimiques solubles dans l’eau. Le groupe 3, constitué de : CE, provient de la minéralisation globale de l’eau. L'eau est alors contaminée à travers les constituants physico-chimiques évalués.

This work aims to assess the physico-chemical quality of the waters of the upper Ouémé in Benin. The study covered four (04) communes. The data was collected in october 2021 and march 2022. The in-situ physical parameters and the chemical parameters in the laboratory were studied. The description by the box plots, the Shapiro-Wilk test and the Kruskall Wallis test at the threshold α = 5% were used. The parameters such as salinity, NO_2^-, NO_3^-, NH_4^+, PO_4^(3-), Ca2+, Mg2+, Fe2+ and the Cl- are significantly different from the other parameters and do not respect the standards of the surface water. The results of the Hierarchical Ascending Classification (HAC) have helped us to identify three groups. The group 1, made up of: pH, DO, Salinity, 〖 NO〗_2^-, NO_3^-,〖 NH〗_4^+,〖 PO〗_4^(3-), Ca2+, Mg2+, Fe2+ and the Cl-; come mainly from agricultural activities and wastewater. The group 2, made up of: T°C, STD and COD; come from the different chemical elements that are soluble in water. The group 3, made up of: CE, comes from the global mineralization of water. The water is then contaminated through the physico-chemical constituents which have been evaluated.
Antonella Sannino, Reading William of Auvergne, SISMEL–Edizioni del Galluzzo, Firenze 2022 (Micrologus Library, 113), VI + 193 PP., ISBN: 9788892901667
Authors: Jakubecki Natalia 
Published: April 2023

Review of:
Antonella Sannino, Reading William of Auvergne, SISMEL–Edizioni del Galluzzo, Firenze 2022 (Micrologus Library, 113), VI + 193 PP., ISBN: 9788892901667.
Jean-Claude Schmitt, Le cloître des ombres, suivi de la traduction française du Livre des révélations de Richalm de Schöntal avec la collaboration de Gisèle Besson, Éditions Gallimard, Paris 2021 (Bibliothèque des histoires), 469 PP., ISBN: 9782072931468
Authors: Casagrande Carla 
Published: April 2023

Review of:
Jean-Claude Schmitt, Le cloître des ombres, suivi de la traduction française du Livre des révélations de Richalm de Schöntal avec la collaboration de Gisèle Besson, Éditions Gallimard, Paris 2021 (Bibliothèque des histoires), 469 PP., ISBN: 9782072931468.
Dimensional analysis-based head loss calculation for the micro-pressure filtering and washing tank
Authors: Tao Hongfei , Wu Zijing , Yang Yuankun , Zhou Yang , Li Qiao , Mahemujiang Aihemaiti , Jiang Youwei 
Published: April 2023

Abstract

Filtering is an important measure for the prevention of emitter clogging in micro-irrigation systems. Head loss and energy consumption are two problems in pressurized irrigation systems. Therefore, a combined filtration device – micro-pressure filtering and washing tank – was designed. In this study, the micro-pressure filtering and washing tank was taken as the research object, and a physical model test of inlet flow and sediment concentration was carried out. The head loss prediction model of the micro-pressure filtering and washing tank under clean water and muddy water conditions was established by dimensional and multiple regression analyses, and the determination coefficients (R2) were 0.987 and 0.953, respectively. In addition, the test data were used to validate the head loss prediction model for muddy water. The average relative error of the predicted values was 3.36%, suggesting that the proposed models are ideal for head loss prediction. The research results can provide technical support for the structure optimization and filtration mechanism of the micro-pressure filtering and washing tank, and enrich the theory of micro-pressure filtration.
Health-related quality of life of pediatric living donor liver transplantation donors who undergone donation surgery for 10 years†
Authors: Lu Ye-Feng , Gao Lei-Qing , He Kang , Xi Hui-Qin 
Published: April 2023

Abstract

Objective: To investigate the quality of life (QOL) of living donor liver transplantation (LDLT) donors.

Methods: The EuroQol 5-dimensional questionnaire (EQ-5D) was used to measure the QOL of donors.

Results: One donor reported “a little problem” of mobility (MO), and 2 donors (9.1%) reported “a little problem” of usual activities (UA). Moreover, there were 8 donors (36.4%) and 7 donors (31.8%) declaring “a little problem” of pain/discomfort (PD) and anxiety/depression (AD), respectively. And both dimensions have a donor reporting “moderate problem.” The mean visual analog scale (VAS) was 83.1 ± 12.4.

Conclusions: Donors can gain a stable and preferable QOL after donation in both the short and long terms. ED-5D application in the field of liver transplant could be an effective choice in QOL studies.
Pengaruh Pengalaman Konsumen dan Teman Sebaya Terhadap Sikap Konsumen Menggunakan Kartu Provider Pada Mahasiswa Prodi Pendidikan Ekonomi FKIP Universitas Jambi
Authors: Kuswanto Kuswanto , Afrilia Rizki Mutiara , Putra Iwan 
Published: April 2023

Dalam mengkonsumsi barang dan jasa, konsumen akan membentuk sikapnya. Berdasarkan observasi yang dilakukan terdapat sikap kurang positif yang terbentuk pada konsumen terlihat dari mayoritas mahasiswa pernah dan sering beralih ke provider lain, hanya 21,4% siswa yang memiliki sikap positif dengan tidak beralih ke provider lain dan tetap menggunakan provider yang digunakannya. Penelitian ini bertujuan untuk mengetahui pengaruh pengalaman konsumen dan teman sebaya terhadap sikap konsumen baik secara parsial maupun simultan. Penelitian ini adalah penelitian kuantitatif, dengan metode ex post facto. Populasi dalam penelitian ini adalah mahasiswa Program Studi Pendidikan Ekonomi FKIP Universtas Jambi angkatan 2017 dan 2018 sebanyak 140 orang dan diambil sampel secara purposive sampling dengan karakteristik sebagai pengguna kartu provider sebanyak 104 orang. Hasil penelitian ini yaitu pengalaman konsumen berpengaruh terhadap sikap konsumen menggunakan kartu provider. Teman sebaya berpengaruh terhadap sikap konsumen menggunakan provider card. pengalaman konsumen dan teman sebaya berpengaruh positif dan signifikan terhadap sikap konsumen menggunakan kartu provider bagi mahasiswa Program Studi Pendidikan Ekonomi FKIP Universitas Jambi.
TINGKAT AKTIVITAS FISIK DAN STATUS GIZI SISWA SEKOLAH DASAR DI KOTA SURABAYA PASCA PTM 100% PANDEMI COVID-19
Authors: Rizkanto Billy Emir , Hayati Hayati , Anisa Putri Juliah , Anwar Shinta Nuriyah , Harun Harun 
Published: April 2023

Covid-19 pandemic had an effect on students tegarding changes in sedentary lifestyle during studying at home, coupled with advances in technology which has caused student to prefer games that less phsycal activity, this is feared to still be a habit for students, after covid-19 pandemic. Studying at school that has been proclaimed by Surabaya government, causing a decrease an increased risk of obesity in student. Therefore this study aims to provide an overview the physical activity level and nutritional status of elementary school in Surabaya. this study were examining nutritional status through Body Mass Index and physical activity level using (IPAQ) for student in three elementary schools in Surabaya. the average nutritional status of student based on BMI/age is 19,5±4,02, 1,02% severely thinnes, 21,94% thinnes 56,63% normal, 16,83% overweight and 3,57% obese, the average level of physical activity is 1037±851 MET-min/week, 46,42% low, 40,81% moderate, 12,75% high. This shows that elementary school student in Surabaya have good nutritional status but have a level activity that tends to be less.
Sequência Didática Gamificada Investigativa como estratégia pedagógica para o ensino de Microbiologia
Authors: Zocche Elis Regina dos Reis , Souza Hilton Marcelo de Lima 
Published: April 2023

O ensino sobre os microrganismos tem sido sempre um desafio, tanto pela falta de recursos físicos na escola quanto pela mistificação de que todos são maléficos. Diante dessa realidade, este trabalho teve como objetivo aplicar uma Sequência Didática Gamificada Investigativa (SDGI), tendo a importância de bactérias e fungos em nosso cotidiano como temática central e validá-la em meio ao período de ensino remoto/híbrido de uma escola pública de Mato Grosso, Brasil. Após aplicação, os alunos avaliaram a proposta didática através de um questionário semiestruturado baseado na metodologia ARCS. Os dados foram analisados por estatística descritiva e análise de conteúdo. Os resultados da aplicação e validação demonstraram que a SDGI contribuiu para a desmistificação sobre bactérias e fungos de maneira motivadora, divertida e engajada. Assim sugere-se que o uso desta abordagem didática pode contribuir significativamente para melhoria das aulas de biologia, sendo aplicável tanto para o ensino híbrido quanto presencial.