bluuebunny/crossref_metadata_2025_split huggingface dataset:
The State- and Trait-Level Effects and Candidate Mechanisms of Four Mindfulness-Based Cognitive Therapy (MBCT) Practices: Two Exploratory Studies
Authors: Maloney Shannon , Surawy Christina , Martin Maryanne , Montero-Marin Jesus , Kuyken Willem 
Published: August 2023

Abstract
Objectives
The primary aim was to explore state- and trait-level effects and candidate mechanisms of four Mindfulness-Based Cognitive Therapy (MBCT) practices.

Method
One hundred sixty adults self-selected from the general population were randomized to one of four mindfulness practices: body scan, mindful movement, breath and body, and befriending. Study 1 explored state-level self-compassion, mindfulness, decentering (mechanisms), and pleasantness of thoughts, emotions, and body sensations at multiple time points using two single mindfulness sessions. Study 2 explored trait-level self-compassion, mindfulness, decentering, interoceptive awareness, attentional control (mechanisms), anxiety, depression, and psychological quality of life pre-post 2 weeks of daily practice.

Results
In study 1, state-level effects were demonstrated in all candidate mechanisms and outcomes within the whole sample across time points (d = 0.27 to 0.86), except for state decentering. After controlling for pre-scores and additional covariates, no between-group effects were found (p = 0.050 to 0.973). In study 2, trait-level effects were demonstrated in psychological quality of life and most candidate mechanisms within the whole sample (d = 0.26 to 0.64) but no between-group effects were found (p = 0.080 to 0.805). Within the whole sample, after controlling for pre-scores, changes in mindfulness, self-compassion, decentering, and interoceptive awareness (i.e. body listening) were associated with improvements in psychological quality of life (r = 0.23 to 0.40) and self-led mindfulness practice (r = 0.18 to 0.23).

Conclusions
Future research should test the generated hypotheses using well-designed, adequately powered, and theory-driven studies that address universal and specific mechanisms in different populations and contexts.

Pre-registration
This study is not pre-registered.
Senescence-associated secretory phenotype constructed detrimental and beneficial subtypes and prognostic index for prostate cancer patients undergoing radical prostatectomy
Authors: Feng Dechao , Wang Jie , Li Dengxiong , Wu Ruicheng , Wei Wuran , Zhang Chi 
Published: August 2023

Abstract
Background
Cellular senescence is growing in popularity in cancer. A dual function is played by the senescence-associated secretory phenotype (SASP) that senescent cells produce in the development of pro-inflammatory niches, tissue regeneration or destruction, senescence propagation, and malignant transformation. In this study, we conducted thorough bioinformatic analysis and meta-analysis to discover detrimental and beneficial subtypes and prognostic index for prostate cancer (PCa) patients using the experimentally confirmed SASP genes.

Methods
We identified differentially expressed and prognosis-related SASP genes and used them to construct two molecular subtypes and risk score. Another two external cohorts were used to confirm the prognostic effect of the above subtypes and risk score and meta-analysis was further conducted. Additionally, functional analysis, tumor stemness and heterogeneity and tumor microenvironment were also evaluated. We completed analyses using software R 3.6.3 and its suitable packages. Meta-analysis was performed by software Stata 14.0.

Results
Through multivariate Cox regression analysis and consensus clustering analysis, we used VGF, IGFBP3 and ANG to establish detrimental and beneficial subtypes in the TCGA cohort, which was validated through other two independent cohorts. Meta-analysis showed that detrimental SASP group had significantly higher risk of biochemical recurrence (BCR) than beneficial SASP group (HR: 2.48). Moreover, we also constructed and validated risk score based on these genes to better guide clinical practice. DNA repair, MYC target, oxidative phosphorylation, proteasome and ribosome were highly enriched in detrimental SASP group. Detrimental SASP group had significantly higher levels of B cells, CD8+ T cells, homologous recombination deficiency, loss of heterozygosity, microsatellite instability, purity, tumor mutation burden, mRNAsi, differentially methylated probes and epigenetically regulated RNA expression than beneficial SASP group. The top mutation genes between detrimental and beneficial SASP groups were SPOP, FOXA1, KMT2C, APC, BSN, DNAH17, MYH6, EPPK1, ZNF536 and ZC3H13 with statistical significance.

Conclusions
From perspective of SASP, we found detrimental and beneficial tumor subtypes which were closely associated with BCR-free survival for PCa patients, which might be important for the furture research in the field of PCa.
Trends and perioperative mortality in gastric cancer surgery: a nationwide population‑based cohort study
Authors: Peltrini Roberto , Giordani Barbara , Duranti Giorgia , Salvador Renato , Costantini Mario , Corcione Francesco , Bracale Umberto , Baglio Giovanni 
Published: August 2023

AbstractThis study aimed to investigate changes and perioperative mortality over a 6-year period within the Italian Hospital Information System among patients with gastric cancer (GC) who underwent gastrectomies and to identify risk factors associated with 90-day mortality. Additionally, nationwide differences between high and low-volume hospitals were evaluated. A nationwide retrospective study was conducted using patient hospital discharge records (HDRs) based on the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) classification. The HDRs were linked to the National Tax Registry records using deterministic record linkage. The data were obtained from the Italian National Outcomes Evaluation Programme (PNE). Multivariate logistic regression was used to examine risk factors for 90-day mortality among patients with GC who underwent partial or total gastrectomies over the period from 2018 to 2020 with adjustment for comorbidities. Overall, the number of patients with GC who underwent total or partial gastrectomies steadily decreased in Italy from 5765 in 2015 to 4291 in 2020 (p < 0.001). The use of the laparoscopic approach more than doubled from 2015 (10.8%) to 2020 (26.3%), with a concomitant conversion rate from laparoscopy to open surgery decreasing from 7.7 to 5.8%. The 30 and 90-day mortality rates remained stable over time (p > 0.05). Low-volume hospitals had higher inpatient, early, and late mortality compared to high-volume hospitals (5.9% vs 3.8%, 6.3% vs 3.8%, and 11.8% vs 7.9%, respectively; p < 0.001). Multivariate logistic regression analysis showed that an advanced age (adjusted odds ratio: 3.72; 95% [CI]: 3.15–4.39; p < 0.001), an open approach (adjusted-OR: 1.69, 95% CI: 1.43–1.99, p < 0.001) and a total gastrectomy (adjusted-OR: 1.44, 95% CI: 1.27–1.64, p < 0.001) were independent risk factors for 90-day mortality. Additionally, patients with GC who referred to high-volume hospitals were 26% less likely to die within 90 days after a gastrectomy than those who underwent surgery in low-volume hospitals. During the 6-year period, surgeons implemented a minimally invasive approach to reduce the conversion over time. Centralisation was associated with better outcomes while advanced age, an open approach, and total gastrectomy were identified as risk factors for 90-day mortality.
Performance Optimization of a Multi-groove Water Lubricated Journal Bearing with Partial Slip by Taguchi Analysis
Authors: Ganesha A. , Joseph Albin , Pai Raghuvir , Khader Shah Mohammed Abdul , Kumar Nitesh , Kumar Shiva , Girish H. 
Published: August 2023

AbstractThe importance of preserving the ecological balance has paved the way for developing water lubricated bearings for marine vessels and other various applications. These bearings have found widespread applications in high pressure water pumps, water-power plants and power generation stations in sea, mining industries, ships, boats and submarines. To investigate the performance envelope of a water lubricated journal bearing (WLJB) with partial slip/no slip pattern, a multi-groove bearing model is developed and analyzed using CFD in the present study. Taguchi analysis method is utilized to determine the highest influential parameter affecting the pressure distribution and load-carrying capacity of a water lubricated journal bearing. From Taguchi method, optimum values identified for design parameters such as attitude angle, groove angle, groove height and number of grooves are 60°, 9°, 7 mm and 2, respectively. For the optimum combination model, a higher load bearing capacity of 1484.5 N is attained. Approximately, 2.88 times increase in peak pressures are noted from the current optimal bearing model by comparing with previous findings. Results indicated that the number of grooves and groove angle are the most influential parameters affecting the bearing load capacity. Partial slip conditions are applied at the grooved surfaces of a bearing model designed based on the identified optimal groove parameters. Influence of varying slip intensity on bearing load capacity is analyzed using CFD simulation. Appropriate selection of slip regions and slip amplitude is found to play a major role influencing the performance of the water lubricated journal bearing.
Stadium IIA/B-seminoma testis: retroperitoneale lymfeklierdissectie als alternatief voor chemotherapie en radiotherapie?
Authors: Alberts Arnout R. , Zuiverloon Tahlita C. M. 
Published: August 2023

SamenvattingDe standaardbehandeling voor stadium IIA-seminoma testis (1 tot 5 vergrote retroperitoneale lymfeklieren ≤ 2 cm) en stadium IIB-seminoma testis (lymfeklieren 2–5 cm of > 5 klieren) bestaat uit chemotherapie of radiotherapie. De curatiekans na behandeling is zeer hoog, maar op de lange termijn is er risico op cardiovasculaire morbiditeit, secundaire maligniteiten en oversterfte als gevolg van de radio- of chemotherapie. Recent hebben zes cohortstudies de effectiviteit van primaire retroperitoneale lymfeklierdissectie (RPLND) bij stadium IIA/B-seminoma testis onderzocht. Met een primaire RPLND zonder adjuvante therapie blijft 70–80% van de patiënten recidiefvrij. Hoewel een minimaal-invasieve (robotgeassisteerde) RPLND een alternatief kan zijn voor chemotherapie of radiotherapie lijkt een recidiefpercentage van 20–30% onacceptabel. Risicostratificatie is noodzakelijk voor een betere patiëntenselectie. Bij een hoger recidiefrisico zou een voorwaarde voor een primaire RPLND één adjuvante chemokuur kunnen zijn.
On maximal parallel application of rules in rewriting P systems
Authors: Zandron Claudio 
Published: August 2023

AbstractIn rewriting P systems, that is P systems using structured strings instead of atomic symbols, rules can be applied in parallel on all strings, but a single rule at a time can be applied on each string. Nonetheless, parallel application of rules also on each string has been considered in various works. This leads to possible application of rules with conflicting target indications on the same string, and different strategies have been considered to face this problem; relations among different classes of languages generated in this way have been investigated in the literature. We continue the investigation on this subject, by highlighting some relations among different classes of maximally parallel rewriting P systems by means of direct simulations. The advantages of such simulations are highlighted, by showing how theoretical results concerning one such type of systems can immediately be adapted to the corresponding simulating systems.
Numerical study on hybrid metallic sandwich structures subjected to air burst
Authors: Derseh Solomon Abebe , Mohammed Tesfaye Alemu , Urgessa Girum 
Published: August 2023

AbstractThis study presents a numerical investigation on the use of previously unexplored hybrid sandwich protective structural configurations with aim to resist airblast loading. A honeycomb, corrugated sheet, and woven interlaced core configurations are used to develop the hybrid system. An experimental result reported in the previous literature is used for validation of the finite element analysis models using Abaqus/Explicit finite element software with a conventional weapon blast related parametric codes. Then an extended numerical study is conducted further on various hybrid sandwich inner core topologies for maximizing protection against an air blast induced shock wave. The study demonstrated that a protective system, combining square honeycomb metallic cores with X-shaped corrugated sheets and fortified against in-plane compression and buckling, showed excellent shielding capabilities against airblast loading. This configuration also exhibited the highest energy dissipation, the least effective plastic strain, minimal back sheet displacement, and a favorable damage profile.
Grace de Laguna’s 1909 critique of analytic philosophy: presentation and defence
Authors: Katzav Joel 
Published: August 2023

AbstractGrace A. de Laguna was an American philosopher of exceptional originality. Many of the arguments and positions she developed during the early decades of the twentieth century later came to be central to analytic philosophy. These arguments and positions included, even before 1930, a critique of the analytic-synthetic distinction, a private language argument, a critique of type physicalism, a functionalist theory of mind, a critique of scientific reductionism, a methodology of research programs in science and more. Nevertheless, de Laguna identified herself as a defender of the speculative vision of philosophy, a vision which, in her words, ‘analytic philosophy condemns’. I outline her speculative vision of philosophy as well as what is, in effect, an argument she offers against analytic philosophy. This is an argument against the view that key parts of established opinion, e.g. our best theoretical physics or most certain common sense, should be assumed to be true in order to answer philosophical questions. I go on to bring out the implications of her argument for the approaches to philosophy of Bertrand Russell, Willard V. Quine and David Lewis, and I also compare the argument to recent, related arguments against analytic philosophy. I will suggest that de Laguna offers a viable critique of analytic philosophy and an alternative approach to philosophy that meets this critique.
Chinese expert consensus on primary prevention for pelvic floor dysfunction during pregnancy
Authors: Sun Xiuli , Gao Lei , Zhu Hongmei , Jiao Wei , Guo Jianjun , Wang Jianliu , Wei Lihui ,   Sports, Exercise and Health Branch of Chinese Preventive Medicine Association
Published: August 2023

AbstractObjectivePregnancy has been identified as a risk factor for pelvic floor dysfunction (PFD). The aim of this study was to establish primary prevention measures for PFD during pregnancy and reduce the overall incidence of PFD.MethodsWe assembled a panel of 36 experts, including gynecologists, obstetricians, and physiotherapists. Through surveys and expert meetings, the panel reviewed and assessed the safety and effectiveness of various clinical interventions. Based on expert comments from Round 1, a revised list of 8 clinical interventions was developed and submitted for a second round of expert review.ResultsA consensus was reached on the importance of implementing prevention measures to protect pelvic floor function during pregnancy. Experts particularly emphasized the significance of health education, weight management, pelvic floor muscle training, respiratory training, overall exercise, physical activity, and perineal massage.ConclusionThe expert consensus provides comprehensive clinical measures to safeguard pelvic floor function during pregnancy. This paper represents the initial step toward developing scientific recommendations for pregnant women regarding the primary prevention of PFD. Future research should focus on the implementation of these recommendations in clinical practice.
And Still, Ancestors Remain Out of Their Graves: Reflections on Past, Present, and Future Bioarchaeological Practices while Building an Indigenous Cultural Heritage Database in Quebec
Authors: Martin-Moya Diane , Zachary-Deom Christine , Nolet Gaetan , Cross-Delisle Katsitsahente , Kolhatkar Manek , Ribot Isabelle 
Published: August 2023

AbstractThis article addresses past and present bioarchaeological practices and human remains management in Quebec; it focuses on the challenges of creating a bioarchaeological database during a two-phase project initiated in 2018–2019 by the Kahnawake Mohawk Council. Its goal was to help Indigenous communities engaged in repatriation and rematriation procedures. Key information regarding human remains’ current location from the 2018 database served as the basis for a second phase in 2021. Of a total of 345 archaeological sites, storage location could only be confirmed for 35% of 228 Indigenous sites compared to 70% of 77 Euro-Canadian sites. Because Ancestors are the legal property of the finder, the landowner, or both, this missing information poses additional challenges to those wishing to initiate repatriation and rematriation claims. Years of non-Indigenous legal and scientific control created layers of colonial assessments. Current populations must rely on archaeological finds to assess whether they are Ancestors’ “legitimate next-of-kin.” In the meantime, Ancestors remain stored. We show how these problems stem from Quebec's colonial archaeological practices and legal frameworks. We then draw on reciprocity-based archaeology to suggest new ways of taking care of Ancestors that respect Indigenous communities’ beliefs and that involve Indigenous communities in caring for their Ancestors.
Exploring the needs of children and caregivers to inform design of an artificial intelligence-enhanced social robot in the pediatric emergency department
Authors: Nishat Fareha , Hudson Summer , Panesar Prabdeep , Ali Samina , Litwin Sasha , Zeller Frauke , Candelaria Patricia , Foster Mary Ellen , Stinson Jennifer 
Published: August 2023

Abstract

Background & Objective:
Socially assistive robots (SARs) are a promising tool to manage children’s pain and distress related to medical procedures, but current options lack autonomous adaptability. The aim of this study was to understand children’s and caregivers' perceptions surrounding the use of an artificial intelligence (AI)-enhanced SAR to provide personalized procedural support to children during intravenous insertion (IVI) to inform the design of such a system following a user-centric approach.

Methods:
This study presents a descriptive qualitative needs assessment of children and caregivers. Data were collected via semi-structured individual interviews and focus groups. Participants were recruited from two Canadian pediatric emergency departments (EDs) between April 2021 and January 2022.

Results:
Eleven caregivers and 19 children completed 27 individual interviews and one focus group. Three main themes were identified: A. Experience in the clinical setting, B. Acceptance of and concerns surrounding SARs, and C. Features that support child engagement with SARs. Most participants expressed comfort with robot technology, however, concerns were raised about sharing personal information, photographing/videotaping, and the possibility of technical failure. Suggestions for feature enhancements included increasing movement to engage a child’s attention and tailoring language to developmental age. To enhance the overall ED experience, participants also identified a role for the SAR in the waiting room.

Conclusion:
Artificial intelligence-enhanced SARs were perceived by children and caregivers as a promising tool for distraction during IVIs and to enhance the overall ED experience. Insights collected will be used to inform the design of an AI-enhanced SAR.
From ritual to performance: Ta'zieh in Iran today
Authors: Khajehi Yassaman , Biet Christian 
Published: August 2023

AbstractAs a practice and experience,ta'ziehlies at the crossroads between ritual and performance, collective lament and recollection, literature, and folklore. Focusing on the experience of the spectator, this paper discussesta'zieh's liminal status and diverse functions in Iran today. This study is based on observations gathered during fieldwork in the fall of 2017 in Tehran (Grand Bazaar), Isfahan (Falāvarjān), and Kashan (Nushābād). By way of comparison, we further reflect on a video installation by Abbas Kiarostami presented at the Centre Georges Pompidou in Paris in 2003, which challenges common assumptions about the aesthetic and religious effectiveness ofta'zieh. The contrast allows us to elucidate how, by renovating ancient narrative forms, contemporary Iranian performing arts partake in the shaping of individual affects as well as communal emotions.
Midline brain structures in adult Niemann-Pick type C disease: a cross-sectional study
Authors: Walterfang Mark , Takahashi Tsutomu , Di Biase Maria A. , Cropley Vanessa L. , Sasabayashi Daiki , Suzuki Michio , Velakoulis Dennis , Pantelis Christos 
Published: August 2023

AbstractObjective:A range of neuropathological changes occur in the brains of individuals with adult Niemann-Pick type C disease (NPC), a recessive disorder of cholesterol trafficking that results in accumulation of cholesterol and gangliosides in lysosomes, particularly in neurons. One of the most significant regions of grey matter loss occurs in the thalami, which abut the midline. What is not known is whether these are neurodevelopmental in origin well prior to symptomatic onset. We aimed to examine other markers of midline developmental anomalies in adults with NPC.Method:We examined the size of adhesio interthalamica (AI) and cavum septum pellucidum (CSP) (if present) in nine individuals diagnosed with NPC and nine healthy comparison subjects, matched for age and gender, using a 3T magnetic resonance volumetric sequence and measured the length of the AI and CSP in mm.Results:We found that 5/9 NPC patients and 0/9 controls had a missing AI. AI length was significantly shorter in the patient group. No subject in other group had a large CSP, and CSP length did not differ. Duration of illness showed a trend to a negative correlation with AI length in patients.Conclusions:Our findings suggest that adult NPC patients show some markers of early neurodevelopmental disturbance, matching findings seen in psychotic disorders. The differences in AI, but not CSP, suggest neurodevelopmental change may occur early in gestation rather than post-partum. The relationship with duration of illness suggests that there may be atrophy over time in these structures, consistent with prior analyses of grey matter regions in NPC.
ON SUMS INVOLVING THE EULER TOTIENT FUNCTION
Authors: KIUCHI ISAO , TSURUTA YUKI 
Published: August 2023

AbstractLet
$\gcd (n_{1},\ldots ,n_{k})$
denote the greatest common divisor of positive integers
$n_{1},\ldots ,n_{k}$
and let
$\phi $
be the Euler totient function. For any real number
$x>3$
and any integer
$k\geq 2$
, we investigate the asymptotic behaviour of
$\sum _{n_{1}\ldots n_{k}\leq x}\phi (\gcd (n_{1},\ldots ,n_{k})). $