bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards the definition of progressive disease in brain metastasis treated with Laser Ablation: an evidence-based study
Authors: Merenzon Martin A. , Levy Adam S. , Bhatia Shovan , Rivera Cameron , Morell Alexis A. , Semonche Alexa , Daggubati Lekhaj C. , Luther Evan , Komotar Ricardo J. , Shah Ashish H. , Ivan Michael E. 
Published: May 2023

Abstract
Purpose
The postoperative period after laser interstitial thermal therapy (LITT) is marked by a temporary increase in volume, which can impact the accuracy of radiographic assessment. The current criteria for progressive disease (PD) suggests that a 20% increase in size of brain metastasis (BM) assessed in 6–12 weeks intervals should be considered as local progression (LP). However, there is no agreement on how LP should be defined in this context. In this study, we aimed to statistically analyzed which variations in tumor volume were associated with LP.
Methods
We analyzed 42 BM that underwent LITT between 2013–2022. For this study, LP was defined following radiographic features, while PD with a combined clinical and radiographic criterion. A ROC curve was generated to evaluate volume change as a predictor of LP and find the optimal cutoff point. A logistic regression analysis and Kaplan Meier curves were performed to assess the impact of various clinical variables on LP.
Results
Out of 42 lesions, 12 (26.7%) had LP. An increase in volume of 25.6% from baseline within 120–180 days after LITT presented a 70% sensitivity and 88.9% specificity for predicting LP (AUC: 0.78, p = 0.0412). The multivariate analysis showed a 25% increase in volume between 120–180 days as a negative predictive factor (p = 0.007). Volumetric changes within 60–90 days after LITT did not predict LP (AUC: 0.57; p = 0.612).
Conclusion
Volume changes within the first 120 days after the procedure are not independent indicators of LP of metastatic brain lesions treated with LITT.
Malaria, gastrointestinal parasite infection and nutritional status among febrile children in Accra, Ghana
Authors: Darko Bright Amoah , Owusu-Asenso Christopher Mfum , Addo-Osafo Kantanka , Appiah-Lawson Edith , Afrane Yaw Asare , Tette Edem Magdalene Afua 
Published: May 2023

Abstract

Introduction
Malaria and intestinal parasite infection are common in developing countries. These Parasites causes anaemia and malnutrition mostly in children. For this reason, it is important to study these infections and their effects in order to monitor interventions to control them. This study aims to determine prevalence of malaria and intestinal parasite infections and their association with nutritional status among febrile children in Accra, Ghana.
Methods
The study was conducted among febrile children aged 6 months to 5 years attending three health facilities in Accra from May to October, 2022. A total of 315 children were selected for the study. Anthropometric measurement was done for each participant. Blood and stool samples were collected for investigation. Thick and thin blood smears stained with 10% Giemsa were prepared and examined for Plasmodium parasite using microscopy. Stool samples were processed using direct wet mount and formalin-ether concentration method and examined for intestinal parasites using microscopy. Haemoglobin concentration was measured using automatic haematology analyzer.
Results
A total of 24% (76/315) were positive for malaria. Plasmodium falciparum accounted for 77.6% (59/76) of parasitaemia, whereas Plasmodium malariae was 22.4% (17/76). Prevalence of intestinal parasite infection was 10.7% (34/315). Giardia lamblia accounted for 17/315 (5.3%) of the entire children, followed by Ascaris lumbricoides 8/315 (2.5%), Hookworm 6/315 (1.9%) and Trichuris trichiura 3/315 (0.9%). A total of 15/315 (5%) of the participants had co-infection of malaria and intestinal parasite infection. Prevalence of anaemia, malnutrition, stunting, wasting and underweight were (72%), (30.7%), (16.2%), (24.4%) and (57.1%) respectively. Malaria was significantly associated with anaemia (p = 0.000) and underweight (p = 0.013). Ascaris lumbricoides was significantly associated with wasting (p = 0.010). Giardia lamblia was significantly association with malnutrition (p = 0.000) and Stunting (p = 0.000), whereas Hookworm was found to be significantly associated with anaemia (p = 0.021).
Conclusion
Prevalence of IPI in this study was less than previously reported, most likely due to regular deworming of most of the children. However, Malaria and intestinal parasitic infection were significantly associated with anaemia and malnutrition including wasting, stunting, and underweight.
Variation of the Brachial Artery Emerging through an Opening in the Median Nerve: A Case Report
Authors: Rutkowski William E. , Howe Caitlin A. 
Published: May 2023

Abstract
The median nerve maintains a close relationship with the brachial artery in the upper limb. Variability in the formation and distribution of these vessels are frequently encountered during donor body dissections or surgical procedures. This case presents a rare anatomical variation of the brachial artery emerging through an opening in the median nerve. The median nerve formed a small opening without the contribution from additional nerve roots and the remaining vasculature of the upper limb was otherwise normal. An abnormal arrangement of neurovasculature in the arm can cause sensory and motor issues, as well as vascular implications. This variation has clinical significance in surgical interventions and potentially daily functioning. To our knowledge, this is the first report of a small median nerve opening pierced by the brachial artery.
Sonographic Diaphragm Abnormalities are an Unexpectedly Frequent Feature of Long COVID Outpatients with Unexplained Dyspnea and Fatigue
Authors: Deo Prabhav P. , Bailey Joseph I. , Jensen Alexandra S. , Farr Ellen , Fahey Meghan , Isherwood Matthew , Chakka Keerthana , Wolfe Lisa F. , Roy Ishan , Sala Marc A. , Franz Colin K. 
Published: May 2023

Abstract
Purpose The primary aim of this study is to define the sonographic diaphragm phenotype of Long COVID rehabilitation outpatients with non-specific dyspnea and fatigue. We analyzed patients referred from a pulmonary post-COVID clinic that were lacking a specific cardiopulmonary diagnosis for their symptoms. Additionally, we report the functional outcomes of subset of patients who completed an outpatient cardiopulmonary physical therapy program.Methods This was a retrospective cohort study (n = 58) of consecutive patients referred for neuromuscular ultrasound assessment of diaphragm muscle using B-mode technique. Patients were recruited from a single academic hospital between February 25, 2021 and November 22, 2022.Results Sonographic abnormalities were identified in 57% (33/58) of patients, and in the vast majority of cases (33/33) was defined by a low diaphragm muscle thickness. Thinner diaphragm muscles are correlated with lower serum creatinine and creatine kinase values, but there was no association with markers of systemic inflammation. Thirty three patients participated in outpatient cardiopulmonary physical therapy that included respiratory muscle training, and 75.8% (25/33) had documented improvement.Conclusion In the outpatient rehabilitation setting, patients with Long COVID display low diaphragm muscle thickness, but intact muscle contractility, with surprising frequency on neuromuscular ultrasound. We speculate this represents a form of disuse atrophy. Also, these patients appear to have a favorable response to cardiopulmonary physical therapy that includes respiratory muscle training.
Identification of Key Genes in Non-Alcoholic Fatty Liver Disease Development through Bioinformatics Analysis
Authors: Zhang Zhang , Zhu Zhengwen , Wang Shihao , Nie Biao 
Published: May 2023

Abstract
Objective The prevalence of NAFLD has increased globally. We performed bioinformatics analysis to identify key biomarkers associated with NAFLD formation.Methods and results We conducted an analysis of differential expression genes in the GSE164760 dataset from the GEO database, comparing healthy controls, NASH, and NAFLD-HCC. Subsequently, we validated the expression levels of NAFLD-HCC differential genes in TCGA liver hepatocellular carcinoma and identified 7 differential expression genes. We developed a nomogram model to predict the progression from NASH to NAFLD-HCC and found that YWHAZ and pathological stage were independent factors affecting liver cancer prognosis. Based on this, we constructed a prognostic nomogram model. We also discovered a significant positive correlation between YWHAZ expression and obesity, insulin resistance, and NAFLD histological grade. Finally, we utilized various bioinformatics tools such as GEO, Xiantao, UALCAN, and HAP to conduct in-depth research on YWHAZ expression in liver cancer.Conclusion This study indicates that YWHAZ is closely related to the development of NAFLD disease, and these findings provide important references for the prevention and treatment of NAFLD.
Bifurcation and Dynamic Analyses of a Diseased Predator-prey Model With Prey Refuge
Authors: PRADEEP M SIVA , GOPAL T NANDHA , SIVABALAN M , YASOTHA A 
Published: May 2023

Abstract
This article considers an eco-epidemiological model involving infection and refuge in the prey population. The non-negativity of the solution, the existence, and the local stability of all feasible equilibrium points are investigated. Furthermore, the condition to satisfy the existence of Hopf bifurcation near the coexisting equilibrium is derived. Some simulation results were also done to support the primary analytical findings.
Application of Liquid-Phase Preparative Isoelectric Focusing for Comparative Analysis of Abundancy in Differentially Extracted Bacterial Protein of S.Typhi and Invasive Non-Typhoidal Salmonella
Authors: Khan Khairunnisa Abdul Lateef , Kader Zainoodin Sheik Abdul 
Published: May 2023

Abstract
Isolation, purification, and separation of complex mixtures is crucial in proteomic research. The conventional electrophoresis method for antigen characterization has limitations in separating low abundance components and selectively enriching important proteins with high degree of purity. Two-dimensional gel electrophoresis was introduced to overcome these limitations, but it also has inherent shortcomings in detecting hydrophobic proteins, low abundance proteins, or samples with proteins of various concentrations. Therefore, this study aims to develop an innovative approach for the enrichment and characterization of immunoreactive components found in differentially extracted whole cell bacterial protein derived from S.Typhi and S.spp. A modified liquid phase preparative isoelectric focusing (IEF) and SDS-PAGE method was used to purify and characterize the proteins. The modified liquid phase IEF efficiently fractionated the proteins into 20 fractions based on the pI value, providing a high-resolution power for protein separation, high throughput, and ease of performance. The fractionated proteins were then analysed by SDS-PAGE for their molecular weight, providing a simple and cost-efficient method for protein analysis. This innovative approach for the enrichment and characterization of immunoreactive components in differentially extracted whole cell bacterial protein derived from S.Typhi and S.spp has the potential to revolutionize the diagnosis and treatment of typhoid fever and other related diseases. By improving the sensitivity and accuracy of protein analysis, this study may lead to identification of exclusive disease biomarkers for early, accurate diagnosis of diseases, improved prognosis and treatment outcomes.
PyRINEX: A New Multi-Purpose Python Package for GNSS RINEX Data
Authors: Han Jinzhen , Lee Seungjun , Yun Hongsik , Kim Kwangbae , Bae Sangwon 
Published: May 2023

Abstract
Since the first receiver independent exchange format (RINEX) version was released in 1989, it has gone through several versions, making the existing software, such as TEQC, incompatible with certain later versions. This study proposes a new Python package named PyRINEX, which is developed to batch process the most generally used versions of RINEX files, namely 2.0 and 3.0. The proposed package can be used to manage and edit numerous RINEX files as well as perform a GPS sensing data quality check function. PyRINEX can be easily imported into any Python IDE similar to any other open-source Python package, it also makes secondary development easy for users.
Carbon labeling of restaurant meals: A virtual experiment
Authors: Lane Hakan , Pokutnia Oksana , Otto Philipp , Farias Ana Rita , Wezepoel Remco 
Published: May 2023

Abstract

The nutrition industry is characterized by high greenhouse gas emissions, as much as 25–30% of all worldwide climate. Deploying eco-labeling to increase people's awareness about the pollution caused by their dietary choices is being introduced to promote more sustainable consumption. The experiment aimed to explore the effectiveness of different eco-labeling approaches and quantify the expected effect on consumer behavior. The data were collected by conducting an online-based survey in the form of a restaurant visit simulation using the PsyToolkit development tool. A convenience sample of 144 participants was randomly assigned to four groups: a) no label, b) climate-friendly icon for low-emitting choices, c) the CO2 equivalent emissions per meal for all items, and d) a combination of an icon and numbers. This survey showed a 9% reduction in average CO2 equivalent per meal with the certificate alone, 4% with label and number, but no reduction in the group using only the CO emissions number. Female gender and green attitudes are associated with making a green dietary choice, and the graphical approach was more effective than providing the report on CO2 emissions as a pure number. Further research is needed to understand the impact of demographics, lifestyle, and attitudes on the possibilities of becoming greener.
Inhibition of the peptide translated from circPPP1R12A by Myricetin and its possible implication: An in-silicoapproach
Authors: Ghosh Rita , Bagchi Angshuman , Mookherjee Tanusree , Chowdhury Nilkanta , Mitra Anindita 
Published: May 2023

Abstract
Abstract:
CircPPP1R12A translates a unique seventy-two amino acid long peptide that is involved in the onset and progression of colon carcinoma by engaging itself in Mst pathway. The possible interaction of the peptide with Mst1/2 proteins can disrupt the activation of this pathway leading to abrupt cell proliferation. Myricetin, a natural flavonoid molecule, has been evaluated as a possible ligand for the peptide. The binding affinity of Myricetin towards the peptide was investigated through molecular docking and MD simulation studies. Molecular docking studies proposed that thirteen amino acid residues of the peptide were found to interact with Myricetin to bind to it. Different attributes of the dynamics simulation data further revealed that the interplay between Myricetin and the peptide could stabilize the binding. In-silicomutagenesis studies indicated that His40, Phe41, Arg43 and His46 are pivotal for the binding of the peptide to Myricetin. These residues were also taking part in the Mst1/2-peptide complex formation. The interaction of the peptide with the Mst proteins possibly deactivates the Mst pathway hence binding of Myricetin can prevent this deactivation. As a naturally occurring flavonoid, it could be a potentially beneficial dietary compound with therapeutic advantage against colon cancer.
Impacts of acute hypoxia on the short-snouted seahorse metabolism and behaviour
Authors: Gomes Matilde , Lopes Vanessa M. , Mai Monica G. , Paula José R. , Bispo Regina , Batista Hugo , Barraca Catarina , Baylina Núria , Rosa Rui , Pimentel Marta S. 
Published: May 2023

AbstractSeahorses are one of the most unique and enigmatic animals, recognized as flagship species for several conservation issues. Unfortunately, seahorses’ populations have been declining worldwide and their unique lifestyle may constrain the ability of these animals to evolve in the future climate scenarios. They inhabit shallow coastal waters that display daily or seasonal environmental fluctuations, Yet, few studies have scrutinized the impacts of climate changes on these iconic species. Within this context, the objective of this work was to test the effects of an extreme hypoxia exposure (~ 27% dissolved oxygen) on the metabolism, behaviour and food intake of the temperate seahorseHippocampus hippocampus. Regarding metabolism, hypoxia exposure led to a significant reduction in metabolic and ventilation rates. Seahorses showed signs of movement lethargy under oxygen depletion. The results show that hypoxia induces metabolic and behavioural changes that may jeopardize the development and survival of these iconic organisms.
Moderate or major anxiety and depression versus high alcohol consumption in women in Honduras.
Authors: Turcios Eleonora Espinoza , Mendoza Carlos Antonio Sosa , Zambrano Lysien Ivania , Ramos Henry Noel Castro , Pacheco José Manuel Armada , Mejia Christian R. 
Published: May 2023

Abstract

Objective
To determine whether anxiety and moderate or major depression were associated with high alcohol consumption in Honduran women. Methodology: Cross-sectional and analytic study, using the SRQ test as a screening test for anxiety, depression and alcohol consumption, confirmed with the Hamilton test for anxiety and depression. The crossing of these variables was carried out to obtain descriptive, bivariate and multivariate results.
Results
Moderate or greater anxiety was more frequent among those with high alcohol consumption (PRa: 1.49; CI95%: 1.09–2.04; p-value = 0.013), was also frequent among those reporting violence at home (PRa: 1.63; CI95%: 1.36–1.94; p < 0.001) and some history of mental pathology at home (PRa: 1.64; CI95%: 1.44–1.87; Value p < 0.001). Moderate or major depression was more frequent among those reporting violence at home (PRa: 1.54; CI95%: 1.30–1.83; p < 0.001) and having some history of mental pathology at home (PRa: 1.38; CI95%: 1.18–1.63; Value p < 0.001).
Conclusion
A strong association was found between anxiety and high alcohol consumption in this population of women from Honduras, Central America. Intensify screening programs for alcohol consumption in the female population and provide psychological support, as well as conduct future research on a larger scale.
Evaluation of Activated Moringa Oleifera Leaf Green Powder as a Natural Biosorbent for Safranin Dye Removal from Synthetic Wastewater
Authors: Ahmed Harez Rashid , Radha Fuad Hama Sharif , Agha Nian N.M. , Amin Khanda F.M. , Shwan Dler M.S 
Published: May 2023

Abstract
This research investigates the potential of Moringa Oleifera Leaves Green Powder (MOLGP) as a low-cost and efficient biosorbent for removing dye, metals, and bacteria from water. Specifically, Safranin dye's adsorption capacity on MOLGP was examined, and MOLGP underwent base activation with sonication to enhance its adsorption capacity as a nanoparticle. The biosorbent surface characteristics were analyzed using FTIR, SEM, BET, and EDX techniques. XRD analysis confirmed the formation of a semi-crystalline form, and changes in surface morphology and elemental composition were observed after NaOH treatment. The maximum removal efficiency of Safranin was 56.17% under the given conditions, but it significantly improved to 98.96% after undergoing treatments. The adsorption process was exothermic, and there was a decrease in system entropy during treatment. The results showed that Safranin adsorption onto MOLGP was unfavorable at all temperatures, but adsorption onto BAMOLGP was favorable at all temperatures. Eleven statistical functions were employed to estimate the error deviations between experimental and theoretically predicted kinetic adsorption values and isothermals. The data indicated that the first-order and second-order equations best matched MOLOPG and BAMOLOPG, while Freundlich is the best match for isothermal BAMOLOPG.
Knowledge, Attitude and Associated Factors Towards Instrument Processing Among Nurses Working in Ethiopia: A Cross-Sectional Study
Authors: Wake Addisu Dabi 
Published: May 2023

Abstract
Introduction and Objectives
Globally, hospitals have faced substantial problems because of healthcare-associated infections (HAIs). This study was intended to assess knowledge, attitude and associated factors towards instrument processing among nurses working in Asella Referral and Teaching Hospital, Ethiopia.
Methods
Cross-sectional survey was done on 335 nurses working at Asella Referral and Teaching Hospital, Oromia regional state, Ethiopia. The data were collected from December 20 to 29/2021 by face-to-face interview.
Result
A total of 335 nurses were participated in the study and the response rate was 99.11%. This study showed that the level of good knowledge and attitude towards Instrument processing among nurses working at Asella referral and teaching hospital was 61.8%, and 65.4% respectively. The Multivariable logistic regression analysis showed that; average monthly income, working experience, awareness on Instrument processing methods, availability of guideline on instrument processing and department currently serving were factors significantly associated with knowledge towards instrument processing. Gender, awareness on instrument processing, department currently serving and knowledge towards instrument processing were factors significantly associated with attitude towards instrument processing.
Conclusions
The level of good knowledge and positive attitude towards instrument processing among nurses was low. Health educational programs, training, and demonstrations on instrument processing are essential to solve these problems.
Resveratrol Inhibits Restenosis through Suppressing Proliferation, Migration
and Trans-differentiation of Vascular Adventitia Fibroblasts
via Activating SIRT1
Authors: Li Mengyun , Luo Lan , Xiong Ying , Wang Fuyu , Xia Yun , Zhang Zongze , Ke Jianjuan 
Published: May 2023

Aim:
After the balloon angioplasty, vascular adventitia fibroblasts (VAFs), which proliferate, trans-differentiate to myofibroblasts and migrate to neointima, are crucial in restenosis. Resveratrol (RSV) has been reported to protect the cardiovascular by reducing restenosis and the mechanism remains unclear.

Methods:
This study was dedicated to investigate the effect of RSV on VAFs in injured arteries and explore the potential mechanism. In this work, carotid artery balloon angioplasty was performed on male SD rats to ensure the injury of intima and VAFs were isolated to explore the effects in vitro. The functional and morphological results showed the peripheral delivery of RSV decreased restenosis of the injured arteries and suppressed the expression of proliferation, migration and transformation related genes. Moreover, after being treated with RSV, the proliferation, migration and trans-differentiation of VAFs were significantly suppressed and exogenous TGF-β1 can reverse this effect.

Result:
Mechanistically, RSV administration activated SIRT1 and decreased the translation and expression of TGF-β1, SMAD3 and NOX4, and reactive oxygen species (ROS) decreased significantly after VAFs treated with RSV.

Conclusion:
Above results indicated RSV inhibited restenosis after balloon angioplasty through suppressing proliferation, migration and trans-differentiation of VAFs via regulating SIRT1- TGF-β1-SMAD3-NOX4 to decrease ROS.