bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Learning Curve for Laparoscopic Totally Extraperitoneal Herniorrhaphy by Logarithmic Function : Consecutive 291 cases performed by a single surgeon
Authors: Hwang DuYeong , Baik YongHae 
Published: January 2023

Abstract
Purpose
The Totally extraperitoneal(TEP) herniorrhaphy is not an easy technique for beginner surgeons because of the complexity of inguinal anatomy and narrow space of the operation field. The aim of this study is to estimate learning curve of laparoscopic TEP herniorrhaphy using logarithmic function model and the exponential function model. Revealing the number of cases needs to overcoming the early learning curve and minimizing the recurrence rate.
Methods
A retrospective analysis of the first 291 patient who underwent laparoscopic TEP herniorrhaphy by a single surgeon consecutively. A logarithmic function and an exponential function were derived from operating time data. The population was divided into three consecutive groups. Each groups assigned the starting point, the slope of the curve, and the plateau of the curve. We calculated how many operation numbers are needed to achieve reduction expected operating time to mean operating time.
Results
291 patients underwent laparoscopic hernia repair. The mean operation time was 70.3 minutes for unilateral hernias. According to two learning curve models, the operation time was decreased less than mean operation time after the initial 88 cases was performed. As the operation time decreased, the recurrence rate decreased.
Conclusion
According to the two learning curve models, 88 cases are required to overcome the learning curve, minimize revision surgery, and achieve a qualified surgery. Further studies on learning curves and training methods are needed to enable a scientific approach to surgical education and quality improvement in surgical education for surgeons and medical services for patients.
Maternal, fetal, neonatal and breastmilk flecainide concentration during maternal therapy and lactation: A case report
Authors: Zande Johanna A. van der , Cornette Jérôme M.J. , Roos-Hesselink Jolien W. , Flint Robert B. 
Published: January 2023

Abstract
Background: Mothers requiring the antiarrhythmic agent flecainide are often advised not to breastfeed, because of the lack of data concercing neonatal effects and flecainide plasma concentrations following maternal exposure as well as via lactation. This is the first report on combined maternal, fetal, neonatal and breastmilk flecainide concentrations in a breastfed infant of a mother requiring flecainide treatment.
Case presentation: All maternal flecainide concentrations fell within the therapeutic range. The fetal to maternal flecainide ratio was 0.72 and the milk to maternal ratio was 2.5. The relative infant dose received via breastmilk compared to maternal dose was 5.6%. Neonatal plasma concentrations were not detectable, despite the flecainide accumulation in breastmilk. All electrocardiograms to assess the neonatal antiarrhytmic effect were normal.
Conclusions: Our results assume that flecainide can be prescribed safely to lactating mothers. Quantification of drug concentrations in neonatal blood in addition to measurements in maternal and fetal blood, and breastmilk, are helpful to evaluate the effects and safety of maternal medication use during pregnancy and lactation.
Imaging Tracer Mixing Concentration 2D in a Stream with Hyperspectral Sensing from an Unmanned Aerial System
Authors: Köppl Christian J. , Lemaire Grégory G. , McKnight Ursula S. , Nørregaard Agnete M. , Thiim Thea C. , Bjerg Poul L. , Bauer-Gottwein Peter , Garcia Monica 
Published: January 2023

Abstract

The release of anthropogenic chemicals to streams, stemming from contaminated sites, direct application (rural/urban) or accidental release, represents a significant threat to water resources and thus the health of humans and aquatic ecosystems. Predicting the transport and fate of chemicals is key to quantify contaminant concentrations and develop environmental quality standards (EQS). Tracer tests are a well-established tool for such hydrological investigations in various water-based systems. In stream settings, such experiments have predominantly investigated longitudinal mixing and flow velocities by measuring the tracer concentration in a few discrete locations; few studies have focused on the transversal mixing properties. Recent progress in hyperspectral remote sensing from unmanned aerial systems (UAS) allows advancing the two-dimensional monitoring of tracer tests, by mapping the tracer concentration with a high spatial resolution in narrow streams with difficult accessibility. So far, such methods have only been demonstrated in controlled settings or in ocean waters, but not in optically complex streams. In this study, we evaluated the performance of a miniaturized hyperspectral imaging system and a consumer grade camera on board of an UAS, to map the concentration of the fluorescent tracer Rhodamine WT in a stream impacted by a contaminated site. In order to estimate tracer concentrations from the remotely sensed data, a band ratio of the red and blue band was used for the photo camera, while a vector based method, estimating the spectral angle in regards to a reference spectrum was applied for the hyperspectral data. The photo camera performed well, but it only mapped reliably the concentration in sections of the stream exposed to direct sunlight (R2: 0.83; nRMSE: 10.2 %), failing to map the concentration in all locations, which included locations where the direct sunlight was blocked by riparian trees (R2: 0.17; nRMSE: 28.7 %). In contrast, the advanced spectral information allowed the hyperspectral-based system to map the concentration well in all sections of the stream (R2: 0.76; nRMSE: 15.1 %), regardless of illumination changes. This demonstrated the advantage of optical cameras measuring water-leaving irradiance from hundreds of contiguous narrow spectral bands that also allow detecting finer spectral absorption and emission features. The results presented here would help to improve the knowledge about mixing of contaminants in streams, i.e. to predict the location of fully transversal mixing for contaminant sites discharging to streams via groundwater-surface interactions, as well as general assumptions behind mixing and dilution models.
Cumulative response of Tempranillo vines subjected to the crop forcing technique to pre-forcing and post-veraison water stress on yield and grape and wine quality
Authors: Oliver-Manera Jordi , García-Tejera Omar , Mata Mercè , Girona Joan 
Published: January 2023

Abstract
Elevated temperatures during berry ripening are detrimental to grape quality. The crop forcing technique (summer pruning that ‘forces’ the vine to start a new cycle) increases must acididy and malic acid concentration at harvest by delaying the date of veraison. However, little information is available on the sensitivity to water stress sensitivity of forced vines. A 3-year experiment was conducted to test three irrigation strategies in forced vines: a minimum threshold of mid-day stem water potential (Ψs) of -0.75 MPa before forcing (DI), minimum threshold of Ψs -1.2 MPa only after veraison (RDI) and the combination of both treatments (DI + RDI). Results were compared to a non-forced treatment with a minimum threshold of Ψs of -1.2 MPa after veraison (C-RDI). Must acidity was increased, and pH decreased in the forced treatments. However, yield was reduced by 35% and irrigation requirements increased by 20% when comparing forced and unforced treatments. As a result, water use efficiency was reduced in forced vines. Only after a dry spring, DI (11%) and DI + RDI (30%) saved water compared to C-RDI. Moreover, although punctual Ψs before forcing never fell below − 0.75 MPa, a significant negative correlation (R2 = 0.76) was found between the integral of water stress before the vines were forced and the number of forced bunches per vine. On the other hand, water stress after veraison in forced vines reduced the polyphenol content of the wine. Our fundings suggest that forced vines are extremely sensitive to even mild water stress.
Development of an Enhanced C4.5 Decision Tree Algorithm Using a Memoized Mapreduce Model
Authors: Paul Florence 
Published: January 2023

Abstract
Classification technique in data mining focuses on prediction which is done by classical C4.5 decision tree algorithm, but limited by its computation complexities due to large datasets. However, this results to inefficient implementation of the algorithm with reference to computing time, memory utilization and data complexity. Meanwhile, several researches have been done to curb these limitations. One of such improvements is the parallelizing of the algorithm using the MapReduce model. This involves splitting the large dataset into smaller units and distributing them on multiple computers for parallel processing, but the recursive nature of the algorithm makes the computational cost high due to large number of calculations that are repeated. This research is aimed at further reducing computation time, using memoized MapReduce model that involves storing the result of previous calculations in a cache. Thus, when same calculations re-occur, the cached result is returned, thereby eliminating re-computation.
The effect of weathering on clay mineralogy of Plio-Quaternary sediments and the overlying material on SE slopes of Medvednica Mt., Croatia
Authors: Gverić Zvonka , Tomašić Nenad , Kisiel Marta , Maj-Szeliga Katarzyna , Skiba Michał , Rubinić Vedran 
Published: January 2023

Abstract
Clay mineralogy of Plio-Quaternary sediments of SE slopes of Medvednica Mt. was compared to that of the overlying weathering horizons. Three locations of Plio-Quaternary sediments, representing past weathering products, were sampled along with the overlying material, representing more recent weathering cycles. Particle size distribution, pH and cation exchange capacity (CEC) of the samples were analyzed. Bulk mineralogy was determined using X-ray diffraction (XRD). Clay mineralogy was determined, after carbonate cement, organic matter and free Fe oxides removal, on fractions < 2 and < 0.2 µm using XRD and Fourier-transform infrared spectroscopy (FTIR). Average layer charge of the expandable layers was determined using the O-D method. Major elements content was determined using inductively coupled plasma optical emission spectroscopy (ICP-OES). Bulk mineralogy comprises quartz, feldspars, mica, clay minerals and occasional Al and Fe (oxy)hydroxides. Clay mineralogy differs subtly between samples; dioctahedral expandable clay minerals dominate with illite and kaolinite present. Hydroxyl interlayering of expandables is noted in the surface samples, corresponding to lower CEC values. Average absolute layer charge of the expandable layers is higher in the surface samples and decreases with depth on two of the investigated locations. Overall, clay mineralogy of the Plio-Quaternary sediments reflects a more intensive weathering regime, confirmed by the presence of Al (oxy)hydroxides and lower absolute charge of the expandable layers. The weathered material and soil overlying these sediments shows heterogeneity in genesis, but corresponds to less intense weathering regime, confirmed by the formation of hydroxy-interlayered minerals and higher absolute charge of the expandable layers.
Thermal local quantum Fisher and Wigner-Yanase correlations in a anisotropic two-qubit Heisenberg XYZ model
Authors: Mohamed A.-B. , Rahman A. , Younis S. M. , Zidan N. 
Published: January 2023

Abstract
The thermal quantum correlations’ dynamics of an anisotropic two-qubit Heisenberg XYZ model in the presence of a x-projection external magnetic field are investigated in this paper. We use local quantum-Fisher information (LQFI), and log-negativity, and local quantum-uncertainty (LQU) to analyze the generated quantum correlation dynamics. Using the associated parameters, we demonstrate the successful generation of entanglement and quantum correlations beyond entanglement in the anisotropic spin-chain state. Certain values and ranges of anisotropy, external magnetic field, and spin coupling strength are proposed that can be used to achieve either a non-maximal or maximal quantum correlated state. The characterization of the spin-chain state by various parameters determines the dynamical patterns, degree, and preservation limits of the associated quantum correlations. Finally, the LQFI, LQU, and log-negativity functions’ robustness is highly dependent on their parameters, and they rarely agree on the degree of quantum correlations and dynamical patterns.
Examining the Spatio-temporal changes of Ecosystem Service Value Due to LULC changes: A Case Study on Cox’s Bazar, Bangladesh
Authors: Maruf Jubaier Khalid , Ara Sharmin 
Published: January 2023

Abstract
Ecosystem services can provide information about the functioning of an ecosystem with all of its components. However, natural ecosystems are under immense pressure worldwide for the developing demands. Urbanization is likely to accelerate in the future, particularly in emerging economies, affecting both a local and regional scale. This study aims to assess ecosystem service valuation (ESV) for Cox's Bazar district because this is one of the most significant tourist spots and encountering tremendous LULC changes over the last few decades. Due to tremendous tourist pressure and the huge migration of Rohingyas, this ecologically crucial natural resource base, especially forest, wetland, and sea beaches, continuously suffer and impacts the ecological balance. Different ecosystem components triggered by LULC change & the individual function's value would influence ecosystem service values. Assessing the effects of different land-use scenarios on subsequent changes in ecosystem service has significant implications for sustainable development. This study included six different LULC classes and their effects on ESVs. LANDSAT satellite-derived images for 20 years’ time span from the year 2000 to the year 2021 have been used and calculated for ten years intervals except for the year 2017. In addition, for the years 2030 and 2040, the LULC map and accompanying ESV have been forecasted. Findings show which LULC classes are more prone to change ESV and how ESV changes in this period. The outcome of this study would assist in sustainable land management policy, controlling encroachment on forests, beach areas, and wetlands.
Impacts of introduced species on the fishery potential, ecology and native tilapia populations of Lakes Victoria and Jipe, Kenya
Authors: Omweno Job Ombiro , Omondi Reuben , Ondemo Frederick M. 
Published: January 2023

Abstract
Species introductions have impacted the fishery potential, ecology and native fisheries populations of Lakes Victoria and Jipe. Oreochromis esculentus and Oreochromis niloticus have been widely introduced outside their native range establishing feral populations. However, the impacts of invasive species on management of native species biodiversity has not been documented. The establishment of exotic O. niloticus species populations in Lake Victoria has been accompanied by declining native populations of the O. esculentus and Oreochromis variabilis. These declines have been accelerated by the introduction of Nile perch, Lates niloticus, which preys upon the native O. esculentus, and overfishing of native fisheries which have slow growth rates and low fecundities. Moreover, nutrient pollution and eutrophication have impacted negatively the the food resources for native Singida tilapia O. esculentus. Native Jipe tilapia, Oreochromis jipe is limited in distribution to a small native range in the Pangani system comprising of Lake Jipe, the Pangani River tributaries and the downstream Nyumba ya Mungu Reseivoir. In Lake Jipe, two non-native species O. niloticus and O. esculentus have been introduced. Although the impact of O. niloticus on native O. jipe populations has not been documented, O. jipe has witnessed dwindling catches since the introduction of O. esculentus from the downstream reservoir. The decline can also be attributed to overfishing and the changing ecology of the lake after proliferation of emergent macrophytes such as Typha domingensis. There is need to formulate management policies to monitor and control fishing effort, pollution and protecting the lake and its catchment from degradation caused by human activities.
Alice and the Caterpillar: A More Descriptive Null Model for Assessing Data Mining Results
Authors: Preti Giulia , Morales Gianmarco De Francisci , Riondato Matteo 
Published: January 2023

Abstract
We introduce novel null models for assessing the results obtained from observed binary transactional or sequence datasets, using statistical hypothesis testing. Our null models maintain more properties of the observed dataset than existing ones. Specifically, they preserve the Bipartite Joint Degree Matrix of the bipartite (multi-)graph corresponding to the dataset, which ensures that the number of caterpillars, i.e., paths of length three, is preserved, in addition to other properties considered by other models. We describe Alice, a suite of Markov-Chain Monte-Carlo algorithms for sampling datasets from our null models, based on a carefully defined set of states and efficient operations to move between them. The results of our experimental evaluation show that Alice mixes fast and scales well, and that our null model finds different significant results than ones previously considered in the literature.
Development of a Floating Element Photoelastic Force Balance
Authors: McLaughlin* Bradley , Lawson John , Ganapathisubramani Bharathram 
Published: January 2023

Abstract
We present a floating element force balance design that uses an optical measurement of the force using photoelastic stress analysis. The force sensing element consists of pins embedded in photoelastic polyurethane pads, which generate an internal stress when the floating element is loaded that is observed via a transmission polariscope. A series of known loads and their corresponding fringe patterns allow a calibration matrix to be derived using a polynomial model solved by least squares regression. Finite Element Analysis (FEA) simulation is carried out to validate the proposed method. The balance then measured a lift curve of the NACA0015 wing at low speed. A comparison of the photoelastic balance and a commercial, 6-axis strain-gauge load cell showed typical differences of less than 6%. This optical approach enables accurate measurements with inexpensive and simple components inside the sensor. This work demonstrates that a photoelastic balance is a simple, inexpensive, and sensitive force transducer.
Suicidality and non-fatal self-injury behaviors among people living with epilepsy attending neurology clinic at Zewditu memorial hospital and Amanuel mental specialized hospital, Addis Ababa, Ethiopia: A cross-sectional study
Authors: Anbessie Mohammed N. , Gebrehanna Ewnet , Zewde Yared Z. , Ayele Biniyam A. 
Published: January 2023

Abstract
Background: Suicidality, suicidal ideation, suicide planningand nonfatal self-harm behaviors are more frequent among people living with epilepsy(PLWE) than the general population. The increased risk of suicidality and nonfatal self-harm behaviors and associated factors among people with epilepsy varies across sociodemographic and disease-related factors as well as comorbid psychiatric conditions. This study aimed to determine the magnitude of suicidality and nonfatalself-injury behaviors and identify theirassociated factors among PWE seeking medical care at Amanuel Mental Specialized Hospital and Zewditu Memorial Hospital, Addis Ababa, Ethiopia, in 2021.
Methods: A facility-based cross-sectional study with 345 randomly selected epileptic patients who attended the outpatient neurology treatment service at Amanuel Mental Specialized Hospital and Zewditu Memorial Hospital was conducted from 15 December 2020 to 15 February 2021. The WHO composite international diagnostic interview (CIDI) was used to assess suicidality, depression, and epilepsy-related factors. The association between outcome variables and selected independent variables was tested using a logistic regression model.
Results: The magnitudes of suicidal ideation, suicide planning, and nonfatal self-injury behavior among people living with epilepsy were 21.2%, 18.3%, and 11.9%,respectively. Living alone, poor social support, and comorbid depression were significantly associated with suicidal ideation, suicide planning, and nonfatal self-injury behavior. Individuals who were taking two or more anti-epileptic drugs also showed a statistical association with suicidal ideation (AOR 0.45, 95% CI=.21,.97; p=0.041) and suicide planning (AOR 0.36, 95% CI=.162,.815; p=0.014).
Conclusions: The prevalence of suicidal ideation and nonfatal self-injury behavior among PWE was high among Ethiopian epileptic patients in a hospital setting. Routine screening and proper intervention for comorbid depression as well as avoiding polytherapy might prevent suicidality and nonfatal self-injury behavior. Strong social support also helped prevent suicide and improve quality of life.
CD8 + T cell metabolism and function are suppressed by long-chain fatty acid uptake from the bone marrow microenvironment in Multiple Myeloma
Authors: Gudgeon Bishop , Giles Hannah , Bishop Emma L , Fulton-Ward Taylor , Escribano-Gonzalez Cristina , Munford Haydn , James-Bott Anna , Foster Kane , Karim Farheen , Jayawardana Dedunu , Mahmood Ansar , Cribbs Adam , Tennant Daniel A. , Basu Supratik , Pratt Guy , Dimeloe Sarah 
Published: January 2023

Abstract
Background
Multiple Myeloma (MM) is a plasma cell malignancy that develops in the bone marrow. Function of T lymphocytes is impaired in patients with MM and the bone marrow microenvironment is described as hostile for T cell activity. Precise suppressive mechanisms within the bone marrow microenvironment remain poorly defined but will impact efficacy of bispecific T cell engager and chimeric antigen receptor (CAR) T cell therapies.
Methods
In this study T cell phenotype, function and metabolic activity were analysed within paired bone marrow aspirate and peripheral blood samples from 72 patients across the spectrum of MM, including individuals with premalignant and asymptomatic disease, alongside age-matched controls. This permitted assessment of effects of disease stage and the bone marrow microenvironment. The bone marrow microenvironment was also modelled in vitro using autologous plasma co-culture systems.
Results
Bone marrow CD8+ T cell function decreased with MM development and was consistently lower within bone marrow samples than matched peripheral blood. These changes were accompanied by decreased mitochondrial mass, which correlated tightly with T cell function. Conversely, long-chain fatty acid uptake and peroxidation was markedly elevated in bone marrow CD8+ T cells. In vitro modelling confirmed uptake of bone marrow lipids suppresses CD8+ T function, which was impaired in autologous bone marrow plasma, but rescued by both lipid removal and inhibition of lipid peroxidation. Analysis of single-cell RNA-sequencing data identified expression of fatty acid transport protein 1 (FATP1) in bone marrow CD8+ T cells in MM, and FATP1 blockade also rescued CD8+ T cell function. Finally, analysis of samples from treated patient cohorts identified CD8+ T cell metabolic dysfunction resolves in treatment-responsive but not relapsed MM patients and is associated with substantial functional restoration.
Conclusions
CD8+ T cells are functionally impaired within the MM bone marrow microenvironment. This is accompanied by decreased mitochondrial mass but elevated uptake of long-chain fatty acids. Blockade of FATP1 restores CD8+ T cell function in presence of BM lipids and may therefore represent a novel therapeutic target to augment their activity in the bone marrow in MM and improve efficacy of T cell-directed therapies.