bluuebunny/crossref_metadata_2025_split huggingface dataset:
Einführung eines Informationsabends für prädialytische Patienten
Authors: Nußbaumer Eleonore 
Published: April 2023

ZUSAMMENFASSUNGDer prädialytische Informationsabend soll helfen, die Vorteile der Peritonealdialyse (PD) für Patienten in der prädialytischen Phase aufzuzeigen, um sie als Erstlinientherapie zu empfehlen. Ziel der Einführung des prädialytischen Abends am Dialysezentrum (DTZ) Waldshut war es, die Akzeptanz gegenüber der PD zu verbessern – als ein gleichwertiges Nierenersatzverfahren im Vergleich zur Hämodialyse (HD).Die vorliegende Arbeit ging der Frage nach, ob die Rate an PD durch die prädialytische Veranstaltung erhöht werden kann. Von den 15 Patienten mit ihren Angehörigen nahmen 12 Patienten an einer Umfrage vor und nach der Veranstaltung teil. Nach der Veranstaltung entschieden sich 8 % für die HD, 33 % blieben unentschieden und 59 % wählten die PD als Therapie. Somit konnte die Akzeptanz der Peritonealdialyse signifikant verbessert werden. Die Veranstaltung vermittelte einen deutlichen Wissenszuwachs bezüglich aller Nierenersatzverfahren und es zeigte sich, dass Ängste und Verunsicherungen bei den Patienten und deren Angehörigen stark abnahmen. Bei der Wahl des bevorstehenden Nierenersatzverfahrens konnten die Patienten in ihrer Entscheidung positiv unterstützt werden. Zum nächsten prädialytischen Informationsabend werden künftig die Patienten eingeladen, welche ein hohes Risiko für eine schnelle Progredienz haben. Bei einer glomerulären Filtrationsrate (GFR) von über 22 ml/min/1,73 m² ist ein Gespräch mit dem Patienten über das bevorstehende Nierenersatzverfahren je nach Dynamik und Erkrankungsverlauf noch nicht aktuell.
Leitliniengerechte Tumortherapie ergänzt um komplementäre Verfahren
Authors: Babadag-Savas Burcu , Baydakov Julia , Boyen Johanna , Ehrlich Steve , Isfort Maike , Mackenrodt Svea , Märtens Bettina , Meyer-Bothling Beate , Meyer Heike , Protte Gudrun , Sander Annette , Steinmann Diana ,   Klaus-Bahlsen-Zentrum für Integrative Onkologie im Comprehensive Cancer Center (CCC) der Medizinischen Hochschule in Hannover (MHH)
Published: April 2023

ZusammenfassungDas Klaus-Bahlsen-Zentrum für Integrative Onkologie (KBZ) ist organisatorisch dem Comprehensive Cancer Center (CCC) der Medizinischen Hochschule Hannover (MHH) zugeordnet. Durch die finanzielle Unterstützung der Rut- und Klaus-Bahlsen-Stiftung (RKBS) konnte das Zentrum initiiert und innerhalb der MHH ausgebaut werden. Die bisherigen Einzelprojekte in der onkologischen Komplementärmedizin, die naturheilkundliche Beratung, Gruppenangebote sowie pflegerische Anwendungen wurden im Zentrum zusammengeführt und durch weitere Angebote und Forschungsthemen in der Psychoonkologie, Rehabilitation, Sportmedizin, Ernährungsmedizin und Pflegeforschung ergänzt. Mittlerweile sind im KBZ zwölf Mitarbeitende verschiedener Professionen tätig, die die Patient*innen leitlinienorientiert beraten und mit wissenschaftlich anerkannten Methoden behandeln. Das KBZ stärkt so mit seinen Angeboten und Aktivitäten die ganzheitliche Behandlung von Krebspatient*innen.
Imaging Approach to Portal Hypertension
Authors: Augustine Antony , John Reetu , Simon Betty , Chandramohan Anuradha , Keshava Shyamkumar N. , Eapen Anu 
Published: April 2023

AbstractIncrease in portal venous pressure (termed portal hypertension) is seen in a variety of liver diseases. Imaging tests are useful to detect portal hypertension and identify its cause. Noninvasive tests like abdominal ultrasound and Doppler studies are routinely done in clinical practice for this indication. Cross-sectional studies like computed tomography and magnetic resonance imaging are especially useful to delineate morphological abnormalities in the liver. Invasive tests like assessment of hepatic venous pressure gradient are done less frequently for specific indications. Distinctive imaging findings help differentiate the different causes of portal hypertension like cirrhosis and vascular liver disorders like noncirrhotic portal hypertension, extrahepatic portal venous obstruction, and Budd–Chiari syndrome. Radiological interventions are increasingly used to treat complications of portal hypertension like refractory ascites or refractory bleeding from gastroesophageal varices.
Imaging Features of Rare Hepatic Tumors
Authors: Vikram Raghunandan , Sarna Achal , Stanietzky Nir 
Published: April 2023

AbstractHepatic lesions are commonly encountered in radiology practice. Lesions with classic imaging findings such as hepatocellular carcinoma, cholangiocarcinoma, hemangiomas, focal nodular hyperplasia, and adenomas are well described in literature and easily diagnosed by most experienced radiologists. In the appropriate context, metastases, which are one of the most common lesions encountered by radiologists who practice in predominantly cancer care settings, are also easily diagnosed. However, one may encounter rarer neoplasms which may be challenging to diagnose and manage. Often, these lesions have overlapping imaging features with those of the common lesions mentioned above. Diagnosis of these rarer tumors would require not only interpreting the images in the context of patient's demographics and clinical presentation but also recognizing the unique imaging features of these tumors. The literature is sparse in describing the radiological appearances of these tumors. Diagnosis based solely on imaging criteria is not advised in these instances. Histological confirmation or other prudent follow-up strategies are necessary for confirmation of imaging findings and interpretation. In this article, we will describe known imaging features of a few rarer primary malignant and benign neoplasms in the liver.
Chronic Obstructive Pulmonary Disease and Work: The Continuing Narrative
Authors: Fishwick David , Barber Chris , Wiggans Ruth 
Published: April 2023

AbstractIt has long been recognized that harmful inhaled workplace exposures can contribute to the development of chronic obstructive pulmonary disease (COPD). This article, intended for the clinician, summarizes some of this evidence and some areas of controversy. Current estimates based on pooled epidemiological analyses of population-based studies identify that approximately 14% of the burden of COPD (and 13% of the burden of chronic bronchitis) is attributable to such exposures. In addition to these approaches, various studies implicate specific exposures as contributing. Certain of these relating to cadmium, coal, and respirable crystalline silica are discussed in more detail. Despite this amassed evidence to date supporting associations between COPD and workplace exposures, there have been surprisingly few studies that have attempted to assess the attribution by experts of an occupational cause in cases of COPD. One study, using hypothetical cases of COPD, noted that while expert physicians were willing to make such an occupational link, this was only likely in cases with light smoking histories and a priori defined heavy occupational exposures. Relatively recent data relating to computed tomography (CT) scan appearances may give the clinician a further guide. Several studies from populations have now linked potentially harmful occupational exposures specifically with the presence of emphysema on CT scanning. It will be of interest to see if this finding, along with other clinical attributes of cases such as smoking and family histories, exclusion of asthma, genetic data, and the nature of workplace exposures, will increase the future diagnosis by clinicians of occupational COPD. In the interim, while better diagnostic approaches are developed, we suggest that consideration of an occupational cause is an important part of the clinical investigation of cases of COPD. Finally, we suggest that evidence-based workplace preventive strategies for occupational COPD should be informed by knowledge of which exposures are most important to reduce, and whether and when intervention to reduce exposure at an individual worker level is warranted.
Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in Male Newborn Infants and Its Relationship with Neonatal Jaundice in Thailand
Authors: Paopongsawan Pongsatorn , Kiatchoosakun Pakaphan , Jirapradittha Junya , Chopchoen Mukrawee 
Published: April 2023

Objective The study aimed to explore the prevalence of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency among male newborn infants in northeastern Thailand and its relationship with neonatal jaundice (NJ).
Study Design This prospective cohort study included male newborn infants with gestational age (GA) ≥35 weeks born between July 1, 2019, and March 1, 2021. Cord blood was sent for G-6-PD fluorescent spot test (FST) and results were reported as normal, partial, or complete deficiency. Infants with NJ would have blood tested for total serum bilirubin (TSB) level and other possible causes of NJ. Duration of phototherapy, length of hospital stays, and complications were documented.
Results There were 922 male infants included in this study with 854 (93.1%) term and 63 (6.9%) preterm infants. FST showed 132 infants (14.4%) had G-6-PD deficiency. Incidence of NJ was significantly higher among infants with G-6-PD deficiency compared with infants with normal G-6-PD level (47.7 vs. 25.8%; relative risk [RR]: 2.62, 95% confidence interval [CI]: 1.79–3.82; p < 0.001). Regardless of G-6-PD level, preterm infants had significantly higher incidence of NJ than term infants (52.4 vs. 27.3%; RR: 2.93, 95% CI: 1.75–4.92; p < 0.001). Duration of phototherapy was significantly longer in infants with G-6-PD deficiency with NJ but hospital stays were similar. Infants with combined G-6-PD deficiency and other causes of hemolysis did not have higher TSB level than infants with isolated G-6-PD deficiency. Risk factors associated with NJ were G-6-PD deficiency and preterm infants, whereas more advance GA was associated with reduced risk for NJ.
Conclusion G-6-PD deficiency and preterm infants were important risk factors for NJ. Routine G-6-PD screening, close monitoring for signs of NJ in infant with risks, and appropriate parental counseling should be implemented.
Key Points
Ice nucleation in aqueous solutions of short- and long-chain poly(vinyl alcohol) studied with a droplet microfluidics setup
Authors: Eickhoff Lukas , Keßler Mira , Stubbs Christopher , Derksen Jakob , Viefhues Martina , Anselmetti Dario , Gibson Matthew I. , Hoge Berthold , Koop Thomas 
Published: April 2023

Poly(vinyl alcohol) (PVA) has ice binding and ice nucleating properties. Here, we explore the dependence of the molecular size of PVA on its ice nucleation activity. For this purpose, we studied ice nucleation in aqueous solutions of PVA samples with molar masses ranging from 370 to 145 000 g mol−1, with a particular focus on oligomer samples with low molar mass. The experiments employed a novel microfluidic setup that is a follow-up on the previous WeIzmann Supercooled Droplets Observation on a Microarray (WISDOM) design by Reicher et al. The modified setup introduced and characterized here, termed nanoliter Bielefeld Ice Nucleation ARraY (nanoBINARY), uses droplet microfluidics with droplets (96 ± 4) µm in diameter and a fluorinated continuous oil phase and surfactant. A comparison of homogeneous and heterogeneous ice nucleation data obtained with nanoBINARY to those obtained with WISDOM shows very good agreement, underpinning its ability to study low-temperature ice nucleators as well as homogeneous ice nucleation due to the low background of impurities. The experiments on aqueous PVA solutions revealed that the ice nucleation activity of shorter PVA chains strongly decreases with a decrease in molar mass. While the cumulative number of ice nucleating sites per mass n m of polymers with different molar masses is the same, it becomes smaller for oligomers and completely vanishes for dimer and monomer representatives such as 1,3-butanediol, propan-2-ol, and ethanol, most likely because these molecules become too small to effectively stabilize the critical ice embryo. Overall, our results are consistent with PVA polymers and oligomers acting as heterogeneous ice nucleators.
Binuclear spin-crossover [Fe(bt)(NCS)2]2(bpm) complex: A study using first principles calculations
Authors: Lazaar Koussai , Aouaini Fatma , Gueddida Saber 
Published: April 2023

The spin-crossover [Fe(bt)(NCS)2]2(bpm) complex is studied using spin-polarized density functional theory within the generalized gradient approximation, the Hubbard U and the weak van der Waals interactions in conjunction with the projector augmented wave method in its molecular and periodic arrangements. It is shown that the considered complex has three magnetic configurations [high spin state (HS)–HS, HS–low spin state (LS), and LS–LS] corresponding to those observed experimentally after two transition temperatures Tc(1) of 163 K and Tc(2) of 197 K. For the HS–HS magnetic state, we found that the two Fe centers are antiferromagnetically coupled for both molecular and periodic structures in good agreement with the experimental observations. Our results show that the computed total energy difference between the magnetic state configurations of the considered Fe2 complex is significantly smaller compared to those reported in the literature for other mono- or binuclear compounds.
Eccentricity-paced geomagnetic field and monsoon rainfall variations over the last 870 kyr
Authors: Zhou Weijian , Kong Xianghui , Paterson Greig A. , Sun Youbin , Wu Yubin , Ao Hong , Xian Feng , Du Yajuan , Tang Ling , Zhou Jie , Shi Zhengguo , Jull A. J. Timothy , Zhao Guoqing , An Zhisheng 
Published: April 2023

Whether there are links between geomagnetic field and Earth’s orbital parameters remains unclear. Synchronous reconstructions of parallel long-term quantitative geomagnetic field and climate change records are rare. Here, we present
10
Be-derived changes of both geomagnetic field and Asian monsoon (AM) rainfall over the last 870 kyr from the Xifeng loess–paleosol sequence on the central Chinese Loess Plateau. The
10
Be

GM

flux (a proxy for geomagnetic field-induced
10
Be production rate) reveals 13 consecutive geomagnetic excursions in the Brunhes chron, which are synchronized with the global records, providing key time markers for Chinese loess–paleosol sequences. The
10
Be-derived rainfall exhibits distinct ~100 kyr glacial–interglacial cycles, and superimposed precessional (~23 kyr) cycles that match with those in Chinese speleothem δ
18
O record. We find that changes in the geomagnetic field and AM rainfall share a common ~100 kyr cyclicity, implying a likely eccentricity modulation of both the geomagnetic field and climate.
Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice
Authors: Quan Yi-Zhou , Wei Wei , Ergin Volkan , Rameshbabu Arun Prabhu , Huang Mingqian , Tian Chunjie , Saladi Srinivas Vinod , Indzhykulian Artur A. , Chen Zheng-Yi 
Published: April 2023

Strategies to overcome irreversible cochlear hair cell (HC) damage and loss in mammals are of vital importance to hearing recovery in patients with permanent hearing loss. In mature mammalian cochlea, co-activation of
Myc
and
Notch1
reprograms supporting cells (SC) and promotes HC regeneration. Understanding of the underlying mechanisms may aid the development of a clinically relevant approach to achieve HC regeneration in the nontransgenic mature cochlea. By single-cell RNAseq, we show that MYC/NICD “rejuvenates” the adult mouse cochlea by activating multiple pathways including Wnt and cyclase activator of cyclic AMP (cAMP), whose blockade suppresses HC-like cell regeneration despite
Myc
/
Notch
activation. We screened and identified a combination (the cocktail) of drug-like molecules composing of small molecules and small interfering RNAs to activate the pathways of
Myc, Notch1, Wnt
and
cAMP.
We show that the cocktail effectively replaces
Myc
and
Notch1
transgenes and reprograms fully mature wild-type (WT) SCs for HC-like cells regeneration in vitro. Finally, we demonstrate the cocktail is capable of reprogramming adult cochlea for HC-like cells regeneration in WT mice with HC loss in vivo. Our study identifies a strategy by a clinically relevant approach to reprogram mature inner ear for HC-like cells regeneration, laying the foundation for hearing restoration by HC regeneration.
Stacking effect on the electronic structures of hexagonal GaTe
Authors: Lai Kang , Dai Jiayu 
Published: April 2023

Abstract
Employing first-principles density functional theory calculations with HSE06 hybrid functional, we investigate stacking-driven modifications on geometric and energy band structures of hexagonal GaTe (h-GaTe) with thickness ranging from bilayer to bulk. Our results show the most energetically favorable stacking order is AB′ type, regardless of the number of layers. The energy band structure of bulk h-GaTe exhibits indirect, quasi-direct and direct band gap for AA′, AB and AB′ stacking, respectively. In particular, as the thickness increases from single- to eleven-layers, both the conduction band minimum and valence band maximum are shifted to the

Γ
ˉ

point for AB′ stacking, leading to an indirect-to-direct band gap transition. Further analysis suggests the origin of the band gap transition can be attributed to the enhancement of interlayer coupling introduced by the stacking order.
Magnetic domain-dependent ultrafast optical demagnetization in stripe domain films
Authors: Chen Xiaowen , Adam Roman , Wang Fangzhou , Song Yawen , Pan Lining , Song Chengkun , Heidtfeld Sarah , Greb Christian , Li Qiuyue , Yu Jing , Zhang Jing , Cui Yuanzhi , Li Shandong , Xu Jie , Cinchetti Mirko , Schneider Claus M , Cao Derang 
Published: April 2023

Abstract
We investigated femto- and picosecond-time magnetization dynamics in a ferromagnetic Ni80Fe20 film with varying thicknesses (wedge-shaped film). We observed that the thickness gradient strongly affects the magnetic moment distribution, causing a magnetization reorientation from in-plane to out-of-plane, and formatting a stripe domain (SD) at the thicker end of the wedge. The magnetization dynamics measurements reveal that the part of the film displaying SDs follows a substantially faster demagnetization and magnetization recovery and smaller magnetization quenching compared to the in-plane domain film. The experiments and micromagnetic simulations support that the decrease in relaxation time is caused by a magnetic anisotropy of the films introduced by SD formation. Our results point out that the micromagnetic structure plays an important role in the magnetization dynamics in ferromagnetic films after optically triggered demagnetization.
Metal–insulator transition in composition-tuned nickel oxide films
Authors: Fowlie Jennifer , Georgescu Alexandru B , Suter Andreas , Mundet Bernat , Toulouse Constance , Jaouen Nicolas , Viret Michel , Domínguez Claribel , Gibert Marta , Salman Zaher , Prokscha Thomas , Alexander Duncan T L , Kreisel Jens , Georges Antoine , Millis Andrew J , Triscone Jean-Marc 
Published: April 2023

Abstract
Thin films of the solid solution Nd

1
−
x

La

x

NiO3 are grown in order to study the expected 0 K phase transitions at a specific composition. We experimentally map out the structural, electronic and magnetic properties as a function of x and a discontinuous, possibly first order, insulator–metal transition is observed at low temperature when x = 0.2. Raman spectroscopy and scanning transmission electron microscopy show that this is not associated with a correspondingly discontinuous global structural change. On the other hand, results from density functional theory (DFT) and combined DFT and dynamical mean field theory calculations produce a 0 K first order transition at around this composition. We further estimate the temperature-dependence of the transition from thermodynamic considerations and find that a discontinuous insulator–metal transition can be reproduced theoretically and implies a narrow insulator–metal phase coexistence with x. Finally, muon spin rotation (µSR) measurements suggest that there are non-static magnetic moments in the system that may be understood in the context of the first order nature of the 0 K transition and its associated phase coexistence regime.
A stress defect state measurement method based on low-frequency ACMFL excitation and Hall sensor array collection
Authors: Zhang ShaoXuan , Feng Jian , Lu Senxiang , Dong Xu , Zhang Xinbo 
Published: April 2023

Abstract
The safety testing of ferromagnetic materials, which are the main materials for various machines and equipment, is particularly important. Stress concentration zones (stress defects) cause stress corrosion of ferromagnetic materials, and also have the potential to cause direct damage to ferromagnetic materials. Estimation of stress sources state using electromagnetic nondestructive measurement methods is a critical and difficult problem. In this paper, a visual and intelligent identification method of stress defects in ferromagnetic materials by low frequency AC magnetic flux leakage (ACMFL) technique is proposed. A new three-point compression experiment was designed in this paper. Time-difference vision is established to analyze the ACMFL signal caused by stress defects. A visual transformed convolutional neural network deep learning algorithm has been proposed to identify grayscale patterns pre-processed by the time-difference vision. The results show that the method proposed in this paper elucidates the relationship between the time-difference vision of a stress defect and the stress source state of the mechanical stress. Our proposed method allows to analyze the pressure indenter size of the pressure source of stress defects.
Machine-readable data and metadata of international key comparisons in radionuclide metrology
Authors: Coulon Romain , Toro Federico Grasso , Michotte Carine 
Published: April 2023

Abstract
The digitalization of key comparisons in radionuclide metrology is being studied at the BIPM. Results of comparisons are made available on the BIPM KCDB platform where a PDF/A document can be downloaded. Access to the metadata contained in the PDF is not straightforward. Therefore, the XML and JSON versions of the report are now embedded in the PDF/A document, allowing direct access to the metadata. This achievement is a first step towards the implementation of FAIR (findable, accessible, interoperable, reusable) principles and does not affect the current policy of publishing comparison results. The combination of PDF/A and XML technologies seems to be an effective way to carry out digitalization. The strengths of both technologies can be brought together to meet the FAIR principles and ISO/IEC 17025 compliance. This approach benefits from robust data exchange features such as XML Schema and XML namespaces, as well as secure digital signatures and long-term archiving of PDF/A-3 documents.