bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydraulic and Water quality Analysis for Puzhal Water Treatment Plant, Tamil Nadu, India
Authors: Krishnan Sri Dhivya , Bhuvaneswari P. T.V. , Kumar P. T.V.Suresh 
Published: June 2023

Abstract
Access to clean water is becoming a more challenging problem for people due to urbanization. The contaminations caused through dumping of industrial waste in the existing Water Distribution System (WDS), impose challenges on water quality. Further, the degradation of the hydraulics involved in the WDS also adds to the contamination. Addressing above issues becomes essential, as it may leads to severe health hazard. Continuous monitoring of hydraulics and water quality can be the promising solution to alleviate these issues. In this research, to enable continuous monitoring, the WDS is modeled using EPANET 2.0 software. The case study considered in this research is Puzhal water treatment plant of Chennai. The hydraulic factors modeled are head, pressure, and demand while Chlorine (Cl) level is modeled for water quality. From the proposed work, it is inferred that the Cl level of the Puzhal WTP is maintained within the permissible limit and identified the quantity of water demand for this entire WDS.
Ethanol extract of Ziziphus nummularia ameliorates formaldehyde induced arthritis in rats by regulating oxidative stress biomarkers and hematological profile
Authors: GARG VANDANA , Malhotra Hitesh , Singh Govind 
Published: June 2023

Abstract
Background: Rheumatoid arthritis is an autoimmune inflammatory disorder mainly affects bone and cartilage architecture. The continuous use of NSAIDs and DMARDs is associated with severe toxic effects. Therefore, the current study was designed to scrutinize herb-based therapy for the treatment of RA.
Aim: Evaluation of the anti-arthritic potential of the ethanol extract of Ziziphus nummularia (ETZN) in a formaldehyde-induced arthritis model in rats and elucidates the possible mechanism of action.
Material and Method: Anti-arthritic activity of ETZN was studied at three oral doses i.e. 200, 400 and 600 mg/kg. Selected doses were studied using various clinical parameters (viz. paw volume, inflammatory index, motility test, stair test, anti-nociceptive efficacy, walking track analysis and motor activity) from day1 to day10. On last day the animals were sacrificed for the evaluation of hematological parameters, oxidative stress biomarkers, histological and radiographic studies of the hind paw.
Results: Treatment with ETZN at varying doses markedly elicited a significant (p<0.0001) reduction in paw volume, inflammatory index, and nociceptive action and increases the latency of pain threshold. The anti-arthritic activity is mainly attributed to a reduction in oxidative stress biomarkers as well as restoration of hematological profile in treated animals. Lastly, the anti-arthritic potential was confirmed from histological and radiological analysis which revealed a marked reduction in inflammatory cells and bone destruction as compared to diseased animals.
Conclusion: The study revealed that ETZN exhibits significant anti-arthritic activity via modulation of oxidative stress biomarkers, restoration of hematological profile and improvement in bone architecture.
Jammer Selection for Energy Harvesting-aided Non-Orthogonal Multiple Access: Performance Analysis
Authors: Ho-Van Khuong 
Published: June 2023

Abstract
Energy harvesting-aided non-orthogonal multiple access (NOMA) meets critical requirements of modern wireless networks in terms of spectral efficiency, communication reliability, and energy efficiency. However, information security for it has not received greatly attentions from both industry and academia. This paper proposes jammer selection to meliorate its security performance. To promptly assess the efficacy of the proposed jammer selection, we propose explicit formulas of connection/secrecy throughput and outage probability for both far and near users accounting for non-linear feature of energy harvesters. These formulas are corroborated by Monte-Carlo simulations and quickly generate innumerable results to reveal a significant/slight influence of energy harvesting nonlinearity on communications reliability/information security. In addition, there exist limits on target data/secrecy rates to avoid complete connection outage (i.e. connection outage probability is one) and achieve complete security (i.e. secrecy outage probability is one). Additionally, the proposed (NOMA-and-proposed jammer selection) scheme significantly outperforms its counterparts (NOMA-and-random jammer selection and orthogonal multiple access-and-proposed jammer selection) in terms of both security and reliability. Nevertheless, there is a trade-off between reliability and security. Notably, the proposed scheme obtains optimum security/reliability performance with proper selection of time/power splitting coefficient.
Review of the Effect of Heterogeneity on Wireless Sensor Networks: A Topological Perspective
Authors: Banerjee Partha Sarathi , Mandal Satyendra Nath , De Debashis , Maiti Biswajit 
Published: June 2023

Abstract
Wireless sensor networks (WSN) are critical for IoT, smart cities, smart health, and other smart services. Network characteristics such as energy consumption, latency, dependability, and stability have a significant impact on WSN performance. However, the numerous capabilities of the nodes, as well as the adjustment of different properties, result in a heterogeneous network. A proper classification, assessment, and management of this heterogeneity are crucial for a long-term network operation. This article gives a full topological taxonomy of heterogeneity, as well as a detailed discussion on the effect of heterogeneity on many aspects of WSN. Comparative analysis of the effect of heterogeneity on different parameters of network performance establishes the advantage of heterogeneous WSN in modern networks. Different measurement methodologies for the estimation of heterogeneity are included in the paper. Relevance of properly managed heterogeneity in the state-of-the-art technologies are presented as the possible future applications.
Characterising the energy cascade using the zero-crossings of the longitudinal velocity fluctuations
Authors: Ferran Amélie , Aliseda Alberto , Obligado Martin 
Published: June 2023

Abstract
It is well known that the zero-crossings of the longitudinal velocity fluctuations can be used to estimate the Taylor length scale of turbulence via the Rice theorem. Furthermore, it has recently been shown that they can also be used to compute the turbulence integral length scale.
We show how these two findings can be combined to study single-point statistics in turbulent flows. This approach is advantageous, as it makes possible the characterization of turbulent flows in extremely challenging situations, i.e. statistically unsteady flows or conditions when adequate instrument calibration cannot be maintained.
Using experimental data for a wide range of Reλ from different flows (passive- and active-grid-generated turbulence and planar turbulent wakes), we show how energy cascade variables can be computed solely by using the zero-crossings of the longitudinal velocity fluctuations. Furthermore, using Vorono\"i tessellations, we study zero-crossing clustering properties. In particular, we discuss how its clusters and voids are related to the turbulence cascade.
Biocultural elements and multifunctionality of cassava flour production in agrarian reform settlements in the Extreme South of Bahia, Brazil
Authors: Marchetti Fábio Frattini , Silva Roberta Cristina , Silva Felipe Otávio Campelo , Santos João Dagoberto 
Published: June 2023

Abstract
Artisanal manufacture of cassava flour mobilizes a cultural and biological framework that has developed and been continuously improved over generations of traditional rural workers. Despite this evidence in Brazilian traditional communities, few studies focus on rural settlements of agrarian reform. This paper addresses a broad diagnosis of flour production in rural settlements in the Extreme South of Bahia, Brazil, carried out in 2019. Thirty rural settlements were visited in eleven municipalities, where 107 flour-houses were evaluated. The results present the socioeconomic profiles of local farmers, cassava varieties, types of flour, particularities of production and characteristics of commercialization. Finally, the multiple functions of artisanal production of cassava flour are highlighted, especially related to the social and economic maintenance of settled families, the promotion of food security and sovereignty within and around the settlements, strengthening of the social and cultural fabrics, and the conservation of agrobiodiversity in the rural landscape.
Metatranscriptomics of microbial biofilm succession on HDPE foil: uncovering plastic-degrading potential in soil communities
Authors: MacLean Joana , Bartholomäus Alexander , Blukis Roberts , Liebner Susanne , Wagner Dirk 
Published: June 2023

Abstract
Background Microbial communities in soil are a complex and sensitive system which secures soil health, nutrient cycling and the degradation of natural and xenobiotic substances. Even though plastic pollution is increasing worldwide, very little is known about microbial processes that take place once plastic debris gets incorporated into the soil matrix. In this study, we conducted the first metatranscriptome analysis of polyethylene (PE)-associated biofilm communities in a highly polluted landfill soil and compared their gene expressions to those of a forest soil community within a 53-day period.Results Our findings indicate that the microbial population present in soil contaminated with plastic debris carries a predisposition to both inhabit and degrade plastic surfaces. Surprisingly, the microbial community from an undisturbed forest soil contained a diverse array of plastic-associated genes (PETase, alkB etc.), indicating the presence of an enzymatic machinery capable of plastic degradation. Plastic-degrading taxa were upregulated in the early stages of biofilm and the PE-degrading enzymes alkB1/alkM and transporters such as FadL, livG, livF, livH and livM and fatty acid β-oxidation pathway were active during the maturation of the biofilm. We also found an increase in nitrogen fixation genes in the plastic soil community (but not in forest soil), indicating an essential metabolic adaptation of biofilm communities in the plastisphere.Conclusion With this study, we address the underlying patterns of gene expression during biofilm development of a PE-associated plastisphere in soil and address the pressing question whether or not natural microbial communities carry the potential to biodegrade petrochemical-based plastic in the (soil) environment.
On Geometric Properties of Topologically Charged Ellis-Bronnikov-type Wormhole Spacetime
Authors: Shaikh Absos Ali , Ahmed Faizuddin , Datta Biswa Ranjan , Sarkar Mousumi 
Published: June 2023

Abstract
In this paper, we have studied the geometric properties of topologically charged Ellis-Bronnikov-type wormhole (briefly, TCEBW) spacetime. The TCEBW spacetime is a static and spherically symmetric solution of the Einstein field equations with a non-zero cosmological constant. We obtained several important geometric properties viz. pseudosymmetry due to conformal curvature as well as conharmonic curvature, Ricci generalized pseudosymmetry and Ricci generalized projectively pseudosymmetry. Also, it is shown that the TCEBW spacetime is generalized Roter type, 2-quasi-Einstein, Einstein spacetime of level 3 and its conformal 2-forms are recurrent. As a special case, the geometric properties of Morris-Thorne wormhole spacetime are analyzed. Also, we have shown that the TCEBW spacetime admits an almost $\eta$-Ricci-Yamabe soliton and an almost $\eta$-Ricci soliton. Finally, a comparison between Morris-Thorne wormhole and TCEBW spacetime regarding their geometric structures is exhibited.
MSC: 53B20, 53B25, 53B30, 53B50, 53C15, 53C25, 53C35, 83C15
Decoding Quetiapine's Impact: Antibiotic Efflux, Cell Membrane and Cell Wall Synthesis Genes in the Mouse Fecal Resistome
Authors: Kyono Yasuhiro , Magboo Jonathan D. , Daley Elizabeth A. , Flowers Stephanie A. 
Published: June 2023

Abstract
Background: As the understanding of antimicrobial activity exerted by non-antibiotic pharmaceuticals continues to evolve, the implications for antimicrobial resistance (AMR) in gut bacteria have garnered significant interest. Quetiapine, a commonly prescribed second-generation antipsychotic (SGA) drug, has been implicated in this context. Our prior research has shown that quetiapine contributes to AMR in vitro; however, the exact mechanism and impact of this interaction are unclear. In this study, we aimed to understand the impact of quetiapine on the gut resistome of C57BL/6NHsd adult male and female mice.
Methods: Mice were exposed to quetiapine via drinking water over a 12-week period, and the fecal resistome was assessed longitudinally and compared to a parallel control group that received regular drinking water. Given that AMR genes comprise a small fraction of a metagenome, we utilized a hybrid capture approach to survey longitudinal dynamics of AMR genes and gene variants. Further, we evaluated the minimal inhibitory concentrations of Escherichia coli exposed to quetiapine in vitro as well as isolates cultured from mouse stool to assess changes in antibiotic susceptibility.
Results: We found that quetiapine exposure increased the relative abundance of AMR gene families related to antibiotic efflux, the phosphoethanolamine transferases, and undecaprenyl pyrophosphate-related proteins in the mouse fecal resistome. Consistent with these findings, E. coli isolates, cultured from mice exposed to quetiapine, displayed a significant decrease in sensitivity to colistin when compared to E. colicultured from control mice naive to quetiapine.
Conclusion: This study provides the first evidence that quetiapine, and possibly other SGAs, could contribute to AMR development in complex microbial communities in vivo. These findings underline the importance of further research into the effects of psychiatric medication on the gut resistome to inform more effective clinical practice and antimicrobial stewardship.
Review of Donor Anatomy Prior to Living Donor Liver Transplantation Using Magnetic Resonance Imaging
Authors: Entezari Pouya , Malik Asad , Moazeni Yasaman , Katariya Nitin , Borhani Amir , Gabr Ahmed , Soliman Moataz , Caicedo Juan , Ladner Daniela , Salem Riad , Thornburg Bartley , Christopher Derrick , Borja-Cacho Daniel , Ganger Daniel , Nemcek Albert , Riaz Ahsun 
Published: June 2023

Abstract
Purpose
This study aimed to investigate vasculobiliary anatomical variations in living liver donors (LLDs) during pretransplant evaluation using magnetic resonance imaging (MRI). The accuracy of MRI in estimating graft weight was also evaluated.
Methods
Pre-operative MR imaging data of 100 LLDs were retrospectively assessed, and variations in the biliary, arterial, and venous systems were evaluated. Surgical records were used to identify discrepancies between MRI biliary findings and intra-operative cholangiograms. The image quality was classified as poor, fair, or good. The MRI-estimated weight was compared with the actual explant weight measured during surgery.
Results
Ninety-seven right lobe hepatectomies and 3 left lobe hepatectomies were performed, with 19 patients exhibiting classic anatomy in all three components. Pre-transplant MRI detected biliary, arterial, and venous variations in 42, 40, and 32 donors, respectively. Intra-operative cholangiograms were found to be discrepant with pre-operative MRIs in 35% of the cases. Furthermore, only 29 donors had acceptable image quality in all anatomical components. The mean estimated graft volume was 1015 ± 253 grams, while mean actual graft weight was 828 ± 204 grams. There was a linear correlation between the MRI-estimated graft weight and the actual graft weight (r: 0.83).
Conclusion
The utilization of pre-transplantation MRI in the evaluation of LLDs can provide valuable insights into anatomical variations. However, to avoid discrepancies between imaging and operative findings, it is important to exercise caution during graft volumetry and image interpretation. Furthermore, MRCP volumetry is another important step in ensuring that proper graft size is achieved.
Determining the characteristics of dune sand used in the building of different sites for the desert environment.
Authors: Abdeldjalil Mhammed , Akacem Mustapha 
Published: June 2023

Abstract
In earlier research, it was found that the characteristics of all types of natural sands must be identified in order to know the extent to which they can be used in the desired field. This study is based on the identification of the physical and chemical characteristics of 24 dune sands located in southwest Timimoun and Adrar The majority of the dunes are classified as particles sands. Sand has been used as a building material since antiquity, especially in Saharan regions where dunes are present. According to sand equivalence tests, all sands are extremely clean, which is confirmed by the fineness modulus of the sand. The chemical properties of the different dune sands were analyzed in the laboratory. The chemical analysis showed that the dune sands of these regions are siliceous sands; the lowest dose of siliceous component is 84%, while the maximum concentration of limestone is 9.55%. The sulfate content does not exceed 1.15 meq/l, which confirms the classification of dune sands as inert material. The use of these sands as raw materials in industry is therefore closely controlled. Moreover, this encourages us to further study these sands and use them as granular construction materials.
DKC1 as a Novel and Potential Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma correlating With Immune Infiltrates
Authors: Qi Li , Bao Wenzhao , Ren Zihan , Li Sijia , Zhou Xuwei , Li Wei 
Published: June 2023

Abstract

Objective This study aims to investigate the association between DKC1 expression and prognosis in head and neck squamous cell carcinoma (HNSCC) Methods We obtained RNA-seq data for a cohort of patients with HNSCC from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases for the purpose of analysis. The expression levels of DKC1 were compared between HNSCC and paracancerous tissue to assess their differences. The Transwell invasion assay and flow cytometry were used to detect cellular invasion and apoptosis following the siRNA-mediated knockdown of DKC1 in HNSCC cell lines. Functional enrichment analysis was performed using the DAVID and KEGG databases to explore potential signaling pathways and associated biological functions. Gene set enrichment analysis of a single sample was performed using the ssGSEA algorithm to assess immune cell infiltration and predict sensitivity to immunotherapy. DKC1 methylation status was analyzed using the UALCAN and MethSurv databases. The tumor immune dysfunction and rejection (TIDE) framework was used to compare response rates to immunotherapy in low-versus high-risk patients based on their immune profiles and tumor characteristics. Kaplan-Meier survival curves and log-rank tests were used to compare the overall survival (OS) and disease-specific survival (DSS) of HNSCC patients with different levels of DKC1 expression. Cox proportional hazard regression analysis was performed to determine the independent prognostic value of DKC1. A nomogram was developed based on multivariate Cox regression analysis to predict the probability of OS at 1, 3, and 5 years after diagnosis, using age, M stage, Lymphovascular invasion, and DKC1 expression as predictors. Results Overexpression of DKC1 in HNSCC was meaningfully associated with T stage, pathologic grade, and survival time. DKC1 overexpression resulted in significantly decreased OS and DSS(disease-specific survival). The invasion and proliferative capacity of DKC1 knockdown cells were decreased by Transwell and flow cytometry. Single-factor Cox analysis confirmed DKC1 as an independent negative prognostic marker for OS. There is a close relationship between the hypomethylation status of DKC1 and a bad prognosis. The results of enrichment analysis reflected the NOD-like receptor/ interleukin-17 signaling pathway, drug resistance, leukocyte transepithelial migration, and neuroactive ligand-receptor interaction were enriched pathways. Overexpression of DKC1 was correlated with negative levels of CD8 + T cells, natural killer cells, effector memory T cells, and infiltration of macrophages. Using the TIDE framework, we found that patients with HNSCC in the high-risk group had considerably higher response rates to immunotherapy compared with those in the contrary group. Conclusion DKC1 could be a promising novel prognostic biomarker to predict HNSCC.
Development of Associational Fiber Tracts in Fetal Human Brain. Preliminary Results of a Cadaveric Laboratory Investigation
Authors: Carlo Davide Tiziano Di , Filice Maria Elena , Fava Arianna , Quilici Francesca , Fuochi Beatrice , Cecchi Paolo , Donatelli Graziella , Restani Laura , Nardini Vincenzo , Turillazzi Emanuela , Cosottini Mirco , Perrini Paolo 
Published: June 2023

Abstract
The advent of diffusion tensor imaging (DTI) in addition to cadaveric brain dissection allowed a comprehensive description of an adult human brain. Nonetheless, the knowledge of the development of the internal architecture of the brain is mostly incomplete. Our study aimed to provide a description of the anatomical variations of the major associational bundles, among fetal and early post-natal periods. Seventeen formalin-fixed fetal human brains were enrolled for sulci analysis, and thirteen specimens were dissected under the operating microscope, using Klinger’s technique. Although fronto-temporal connections could be observed in all stages of development, a distinction between the uncinate fascicle, and the inferior fronto-occipital fascicle was clear starting from the early preterm period (25-35 post conceptional week). Similarly, we were consistently able to isolate the periatrial white matter that forms the sagittal stratum (SS) in the adults, with no clear distinction among SS layers. Arcuate fascicle and superior longitudinal fascicle were isolated only at the late stage of development without a reliable description of their entire course. The preliminary results of our study demonstrated that, although white matter is mostly unmyelinated among fetal human brains, cadaveric dissection can be performed with consistent results. Furthermore, the stepwise development of the associational fiber tracts strengthens the hypothesis that anatomy and function run in parallel, and higher is the cognitive functions subserved by an anatomical structure, later the development of the fascicle. Further histological-anatomical-DTI investigations are required to appraise and explore this topic.