bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban Environment and Health: a cross-sectional multiregional project based on Population Health Surveys in Spain (DAS-EP project), study protocol.
Authors: Bereziartua Ainhoa , Cabrera Andrés , Subiza-Pérez Mikel , García-Baquero Gonzalo , Gomez Salvador Delís , Ballester Ferran , Estarlich Marisa , Merelles Antonio , Esplugues Ana , Irles María Ángeles , Barona Carmen , Mas Rosa , Font-Ribera Laia , Bartoll Xavier , Pérez Katherine , Oliveras Laura , Binter Anne-Claire , Daponte Antonio , Mochon Leticia García , Cortés Helena García , Garrido Carmen Sanchez-Cantalejo , Navarro Marina Lacasaña , Cáceres Rocío , Rueda María del Mar , Saez Marc , Lertxundi Aitana 
Published: March 2023

Abstract

Background
The European Environment Agency estimates that 75% of the European population lives in cities. Despite the many advantages of city life, the risks and challenges to health arising from urbanization need to be addressed to tackle the growing burden of disease and health inequalities in the cities. This article presents the study protocol of the Urban Environment and Health: a cross-sectional multiregional project based on Population Health Surveys in Spain (DAS-EP project), that aims to investigate the complex association between the urban environmental exposures (UrbEE) and health.
Methods
DAS-EP is a Spanish multiregional cross-sectional project that combines Population Health Surveys (PHS) and Geographical Information System (GIS) allowing to collect rich individual level data from 17,000 adult citizens participating in the PHS conducted in the autonomous communities of the Basque Country and Andalusia, the Valencian Community, and the city of Barcelona in years 2021–2023. This study focuses on the population living in cities or metropolitan areas with more than 100,000 inhabitants. UrbEE are described by objective estimates at participants’ home addresses by GIS and subjective indicators present in PHS. The health outcomes included in the PHS and selected for this study are self-perceived health (general and mental), prevalence of chronic mental disorders, health-related quality of life, consumption of medication for common mental disorders, and sleep quality. We aim to further understand the direct and indirect effect between UrbEE and health as well as to estimate the impact at the population level taking respondents’ socio-demographic and socio-economic characteristics, and lifestyle into account.
Discussion
This study is a clear commitment to the generation of urban environment indicators within the field of public health with a health equity perspective. The results will be novel for the inclusion of objective & subjective UrbEE as well as the combination of PHS from different study areas and GIS estimates. This methodological approach will provide a large volume of information and a large sample size of the study. The results will ultimately help identify urban indicators, increasing the capacity to detect and intervene in community health, improving the routine surveillance and monitoring of the cities’ health information systems.
Modified Convolutional Neural Networks and Long Short-Term Memory for Host Utilization prediction in Cloud Data Center
Authors: Ullah Arif , Abbasi Irshad Ahmed , Rehman Muhammad Zubair , Alam Tanweer , Aznaoui Hanane 
Published: March 2023

Abstract
Infrastructure service model provides different kinds of virtual computing resources such as networking, storage service, and hardware as per user demands. Host load prediction is an important element in cloud computing for improvement in the resource allocation systems. Hosting initialization issues still exist in cloud computing due to this problem hardware resource allocation takes several minutes of delay in the response process. To solve this issue prediction techniques are used for proper prediction in the cloud data center to dynamically scale the cloud in order for maintaining a high quality of services. Therefore in this paper, we propose a hybrid convolutional neural network long with short-term memory model for host prediction. In the proposed hybrid model, vector auto regression method is firstly used to input the data for analysis which filters the linear interdependencies among the multivariate data. Then the enduring data are computed and entered into the convolutional neural network layer that extracts complex features for each central processing unit and virtual machine usage components after that long short-term memory is used which is suitable for modeling temporal information of irregular trends in time series components. In all process, the main contribution is that we used scaled polynomial constant unit activation function which is most suitable for this kind of model. Due to the higher inconsistency in data center, accurate prediction is important in cloud systems. For this reason in this paper two real-world load traces were used to evaluate the performance. One is the load trace in the Google data center, while the other is in the traditional distributed system. The experiment results show that our proposed method achieves state-of-the-art performance with higher accuracy in both datasets as compared with ARIMA-LSTM, VAR-GRU, VAR-MLP, and CNN models.
The Modified Scattering Vector Geometry Pre-Existing in Partial Wave Analysis
Authors: Bhanumoorthy P. 
Published: March 2023

Abstract
Spherical polar coordinate description cannot permit a substitute angle for polar angle.
We show that scattering angle as substitute for polar angle demonstrates pre-existing right angled scattering triangle in partial wave analysis.
The substitute angle requires a constant $90^\circ$ difference between the two angles for all vectors in the scattering field.
We call the scattering vector geometry with isosceles scattering triangle given in textbooks as the unmodified scattering vector geometry.
The incident and scattered wave vectors are equal in magnitude in the unmodified to explain wavelength invariance in elastic scattering.
We define the modified scattering vector geometry with a right angled scattering triangle with unequal magnitudes of incident and scattered wave vectors.
Vectors in the scattering triangle represent running waves in the unmodified and standing waves in the modified.
The incident vector magnitude in the modified becomes twice the same in the unmodified.
Standing wave description readily explains wavelength invariance in elastic scattering in the modified.
The Native Features of Plantar Pressure Distribution with Centers of Gravity and Foot Posture Among Indigenous Taiwanese
Authors: Chow Tong-Hsien 
Published: March 2023

Abstract
Background
Indigenous Taiwanese were generally considered to have excellent physical fitness and athletic ability. The correlation of these performances with their foot features has rarely been studied. The study aims to explore the static plantar pressure profiles associated with centers of gravity control abilities and foot posture among Indigenous Taiwanese to understand the native outline of unique foot characteristics.
Methods
A cross-sectional retrospective analysis from 165 indigenous college students and 183 healthy age-matched students is conducted. Bipedal static plantar pressure distributions (PPDs) along with arch index (AI) and centers of gravity balance are examined with the JC Mat. Foot posture is determined by estimating the rearfoot postural alignment.
Results
Findings of the study revealing the native outline of indigenous’ foot characteristics were presented as low-arched feet with higher relative loads at the medial and lateral longitudinal arches of the midfoot as well as the medial metatarsals of the forefoot. Footprint image was recognizable as cuboid and navicular dropped appearances. Both performances of balance abilities and rearfoot postural angles were unexpectedly well than the general population.
Conclusions
The native outline of foot features in Indigenous Taiwanese were low arches with navicular and cuboid drops for the midfoot, but their balance and rearfoot posture remained normal. Therefore, the relationships among indigenous foot characteristics, physical performance, sports ability and possible injuries deserve further investigation.
Upper gastrointestinal endoscopic findings in functional constipation and irritable bowel syndrome diagnosed using the Rome IV criteria: a cross-sectional survey during a medical check-up in Japan
Authors: Otani Koji , Watanabe Toshio , Takahashi Kanae , Nadatani Yuji , Ominami Masaki , Fukunaga Shusei , Hosomi Shuhei , Kamata Noriko , Tanaka Fumio , Nagami Yasuaki , Taira Koichi , Kimura Tatsuo , Fukumoto Shinya , Fujiwara Yasuhiro 
Published: March 2023

Abstract
Background The Rome IV criteria have been established as an international standard for diagnosing disorders of gut–brain interaction. In this study, we aimed to examine the upper gastrointestinal (GI) endoscopic findings and symptoms of subjects with functional constipation (FC) and irritable bowel syndrome (IBS) of individuals undergoing a medical check-up.
Methods A total of 13,729 subjects underwent a medical check-up at Osaka City University-affiliated clinic, MedCity21, between April 2018 and March 2019. Among the 5,840 subjects who underwent screening upper GI endoscopy and completed a questionnaire based on the Rome IV criteria, 5,402 subjects were consecutively enrolled after excluding subjects with a large amount of gastric residue (n = 6), those who had previously undergone partial or total gastrectomy (n = 40), or those with continuous use of low-dose aspirin (n = 82), nonsteroidal anti-inflammatory drugs (n = 63), or acid secretion inhibitors (n = 308).
Results Robust Poisson regression analyses adjusted for age, sex, Helicobacter pylori infection status, alcohol intake, and smoking habits showed a significant association between FC and corpus erosion (adjusted prevalence ratio [aPR], 2.93; 95% confidence interval [CI], 1.51–5.67; p < 0.01) and red streaks (aPR, 3.83; 95% CI, 2.53–5.79; p < 0.01), whereas IBS was significantly associated with erosive gastritis (aPR, 8.46; 95% CI, 4.89–14.67; p< 0.01) and duodenitis (aPR, 7.28; 95% CI, 3.64–14.59; p < 0.01). Red streaks tended to be associated with IBS (aPR, 1.96; 95% CI, 1.00–3.83; p= 0.05). Subjects with IBS were the most to complain of both upper and lower GI symptoms, followed by those with FC and controls. Furthermore, subjects with IBS were the most to complain of psychological symptoms, followed by those with FC and controls. IBS subjects with erosive gastritis or duodenitis had significantly more complaints of stomachache and feeling stressed than those without erosive gastritis or duodenitis.
Conclusions Subjects with FC and IBS had a variety of upper GI and psychological symptoms. In the upper GI endoscopic findings, corpus erosion and red streaks were associated with FC, and erosive gastritis, duodenitis, and possibly red streaks were associated with IBS.
The role of depressive symptoms and social support in the association of internet addiction with non-suicidal self-injury among adolescents: a cohort study in China
Authors: Ma Ying , Li Yanqi , Xie Xinyi , Zhang Yi , Ammerman Brooke A. , Lewis Stephen P , Chen Ruoling , Yu Yizhen , Li Fenghua , Tang Jie 
Published: March 2023

Abstract
Background
Both internet addiction (IA) and non-suicidal self-injury (NSSI) are major public health concerns among adolescents, however, the association between IA and NSSI was not well understood. In this study we aim to investigate the association between IA and NSSI within a cohort study, and to explore the mediated effect of depressive symptoms and the moderating effect of social support in the association.
Methods
A total of 1530 adolescents aged 11–14 years who completed both the baseline (T1) and 14-month follow-up (T2) survey of the Chinese Adolescent Health Growth Cohort were included for the current analysis. IA, NSSI, depressive symptoms and social support were measured at T1; depressive symptoms and NSSI were measured again at T2. Structural equation models were employed to estimate the mediated effect of depressive symptoms and the moderating effects of social support in the association between IA and NSSI at T2.
Results
IA was independently associated with an increased risk of NSSI at T2, with the total effect of 0.113 (95%CI 0.055–0.174). Depressive symptoms mediated the association between IA and NSSI at T2, and social support moderated the indirect but not the direct effect of IA on NSSI at T2. Sex differences were found on the mediated effect of depressive symptoms and the moderated mediation effect of social support.
Conclusions
Interventions that target adolescents’ NSSI who also struggle with IA may need to focus on reducing depressive symptoms and elevating social support.
Long working hours and increased risks of lean non-alcoholic fatty liver disease among Korean men and women
Authors: Lim Ga-Young , Chang Yoosoo , Kim Inah , Ryu Seungho , Kwon Ria , Song Jaechul 
Published: March 2023

Abstract
Despite the increasing prevalence of lean nonalcoholic fatty liver disease (NAFLD), its risk factors are not well established. We examined the association between long working hours and incident NAFLD in lean Korean workers with emphasis on sex-based effect modification. This cohort study involved 44,627 non-overweight (BMI < 23 kg/m2) and NAFLD-free Korean workers (mean age, 35.1 years). Working hours were categorized into 35–40 (reference), 41–52, and ≥ 53 hours. The presence of fatty liver and its severity were determined using ultrasonography and NAFLD fibrosis score (NFS), respectively. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using parametric proportional hazards models. Incident cases of 5,738 lean NAFLD developed over a median follow-up of 3.7 years. The incidence of lean NAFLD increased with increasing working hours with a stronger association in men than in women (P for interaction < 0.001). For men, multivariable-adjusted HRs (95% CIs) for lean NAFLD in time-dependent models comparing working hours of 41–52 and ≥ 53 h compared to the reference category were 1.16 (1.06–1.28) and 1.25 (1.12–1.39), respectively. The excess relative risk of developing lean NAFLD with intermediate/high NFS was observed in working hours of 41–52 and ≥ 53 h with a corresponding HR of 1.87 (1.22–2.88) and 1.87 (1.09–3.22), respectively. Conversely, no significant associations were found between working hours and incidence of lean NAFLD in women. In conclusion, long working hours were significantly associated with an increased incidence of lean NAFLD and its severe form in men but not in women.
A multimodal omics framework to empower target discovery for cardiovascular regeneration
Authors: Li Ziwen , Mills Nicholas L. , Brittan Mairi 
Published: March 2023

Abstract
Ischaemic heart disease is a global healthcare challenge with high morbidity and mortality. Early revascularisation in acute myocardial infarction has improved survival, however, limited regenerative capacity and microvascular dysfunction often lead to impaired function and the development of heart failure. New mechanistic insights are required to identify robust targets for the development of novel strategies to promote regeneration. Single cell RNA sequencing (scRNA-seq) has enabled profiling and analysis of the transcriptomes of individual cells at high resolution. Applications of scRNA-seq have generated single cell atlases for multiple species, revealed distinct cellular compositions for different regions of the heart, and defined multiple mechanisms involved in myocardial injury-induced regeneration. In this review, we summarise findings from studies of healthy and injured hearts in multiple species and spanning different developmental stages. Based on this transformative technology, we propose a multi-species, multi-omics, meta-analysis framework to drive the discovery of new targets to promote cardiovascular regeneration.
Strong ground motion from the seismic swarms preceding the 2021 and 2022 volcanic eruptions at Fagradalsfjall, Iceland
Authors: Aguirre Victor Moises Hernandez , Rupakhety Rajesh , Ólafsson Simon , Bessason Bjarni , Erlingsson Sigurður , Paolucci Roberto , Smerzini Chiara 
Published: March 2023

Abstract
The Geldingadalir and Meradalir eruptions at Mt. Fagradalsfjall in the Reykjanes Peninsula on 19 March 2021 and 3 August 2022, respectively, were preceded by intense volcano-tectonic swarms. Eight earthquakes with M ≥ 5 were recorded by the Icelandic Strong Motion Network. We present an overview of the seismicity in Fagradalsfjall, and salient features of the strong ground motion caused by the swarms in the epicentral area. The largest recorded horizontal Peak Ground Acceleration (PGA) was ~ 0.45g at Grindavík, which is the strongest PGA recorded in Iceland since the MW6.3 2008 Ölfus Earthquake. Recorded waveforms show a rich long-period energy content, with a burst of higher frequencies at the beginning of shaking. This leads to larger response spectral accelerations at long periods that those from typical shallow crustal earthquakes. Moreover, an empirical mixed-effects ground motion model for PGA was calibrated based on the available recordings. The attenuation rate of PGA from this model is similar to that introduced by Lanzano and Luzi (2020) which is based on data from volcanic events in Italy, but the magnitude scaling of our model is much lower. The overall results indicate that scaling and attenuation of ground motion from volcanic events and purely tectonic earthquakes in Iceland are likely very different. This is an important observation because seismic hazard in parts of the Reykjavik area and of the central highlands, where important hydroelectric power plants are located, could potentially be dominated by events of volcanic origin. Therefore, it is important to take these observations into account for seismic hazard and risk assessment in Iceland.
SEMA4A promotes prostate cancer invasion: involvement of tumor microenvironment
Authors: Liu Xiao , Tan Weiwei , Zhang Xiaofan , Feng Tingting , Wang Lin , Zhou Wei 
Published: March 2023

Abstract
Background

Semaphorin 4A (SEMA4A) belonged to a family of membrane-bound proteins that were initially recognized as a kind of axon guidance factors in nervous system. It was preferentially expressed on immune cells and has been proven to play a prominent role in immune function and angiogenesis.

Methods and results

SEMA4A expression was analyzed by IHC and it’s highly expressed in PCa tissues and correlated with Gleason scores and distant metastasis. SEMA4A could induce Epithelial-mesenchymal transition (EMT) of PCa cells and consequently promote invasion by establishing a positive loop with IL-10 in stromal cells as evidenced by Western blotting and Invasive assay. In vivo studies showed significantly more tumor cell dissemination in mice injected with SEMA4A-overexpressing cells in both mouse models and both the number and size of lung metastases were significantly increased in SEMA4A-overexpressing tumors. SEMA4A depletion by genetic means prevents lung metastasis in PCa xenograft models.

Conclusion

Our data suggest a crucial role of SEMA4A in PCa and that blockade of SEMA4A- represents an attractive approach to improving therapeutic outcomes.
Serum proteome profiling of naturally acquired Babesia rossi infection in dogs
Authors: Kuleš Josipa , Rubić Ivana , Farkaš Vladimir , Rafaj Renata Barić , Gotić Jelena , Crnogaj Martina , Burchmore Richard , Eckersall David , Mrljak Vladimir , Leisewitz Andrew L. 
Published: March 2023

Abstract
Babesiosis is a disease of significant veterinary importance with worldwide distribution. It is caused by intra-erythrocyte protozoal parasites, with Babesia rossi causing the most severe clinical signs of all the large Babesia parasites infecting dogs. The disease can be clinically classified into uncomplicated and complicated forms with a wide range of clinical presentations from a mild, subclinical illness to complicated forms and death. The aim of this study was to assess serum proteomic profiles from dogs with babesiosis and healthy dogs using a label-based proteomics approach. Altogether 32 dogs naturally infected with B. rossi (subdivided into 18 uncomplicated cases and 14 complicated cases of babesiosis) and 20 healthy dogs were included. There were 78 proteins with significantly different abundances between the three groups of dogs. Elucidation of proteins and pathways involved in canine babesiosis caused by B. rossi have revealed key differences associated with haemostasis, innate immune system, lipid metabolism and inflammation. Shotgun proteomic profiling allowed identification of potential serum biomarkers for differentiation of disease severity in canine babesiosis caused by B. rossi. These findings may be applicable to the study of host-parasite interactions and the development of novel therapeutic targets.
Assessment and Comparison of Competencies, Attitudes and Knowledge of Palliative Care amongst Physicians, Advance Practice Providers, Residents, and Medical Students.
Authors: Kawai Tetsuyuki , Davis William , Weber Nancy 
Published: March 2023

Abstract
Background
Palliative Care prevents and relieves burdensome symptoms and suffering in patients who have life-limiting or chronic illness. This is accomplished through the early identification and treatment of pain and other physical, psychosocial, or spiritual stressors. The creation of a new Palliative Care program at a county teaching hospital in late 2021 and the subsequent rapid expansion of its services generated the need for targeted education programs for medical staff. The first step was to determine Palliative Care competencies, attitudes, and knowledge among the medical personnel at the institution.
Methods
The purpose of this study was to collect and compare baseline self-assessed competencies, attitudes and knowledge of Palliative Care and its applications amongst Physicians/Advance Practice Providers (APPs), Residents/Fellows, and medical students. The email survey was distributed to 322 attending physicians/APPs, 301 resident/fellow physicians, and 447 medical students. 144 total responses were received, with 129 responses being complete, providing a total response rate of 13.5%.
Results
Overall knowledge score of Palliative Care was significantly lower in medical students (7.27 out of a possible maximum score of 12) when compared to attending physicians/APPs (9.64, p < 0.001) and resident/fellow physicians (9.38, p < 0.001). The vast majority of respondents acknowledged that Palliative Care would greatly benefit their own patient population or future patient populations [attending physicians/APPs 74.4%, resident/fellow physicians 94.9%, medical students 80.4%] and that their department/colleagues could benefit from Palliative Care education [attending physicians/APPs 74.4%, resident/fellow physicians 94.9%, medical students 88.2%].
Conclusion
Study findings suggest that medical students have less knowledge and confidence utilizing Palliative Care than practicing physicians/APPs. This suggests that providing Palliative Care Medical Education early in the medical school curriculums could ultimately improve patient care. Similarly, practicing physicians/APPs and trainees at all levels could benefit from further education in Palliative Care.