bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baryonic post-processing of N-body simulations, with application to fast radio bursts
Authors: Williams Ian M , Khan Adnan , McQuinn Matthew 
Published: January 2023

ABSTRACT
Where the cosmic baryons lie in and around galactic dark matter haloes is only weakly constrained. We develop a method to quickly paint on models for their distribution. Our approach uses the statistical advantages of N-body simulations, while painting on the profile of gas around individual haloes in ways that can be motivated by semi-analytic models or zoom-in hydrodynamic simulations of galaxies. Possible applications of the algorithm include extragalactic dispersion measures to fast radio bursts (FRBs), the Sunyaev–Zeldovich effect, baryonic effects on weak lensing, and cosmic metal enrichment. As an initial application, we use this tool to investigate how the baryonic profile of foreground galactic-mass haloes affects the statistics of the dispersion measure (DM) towards cosmological FRBs. We show that the distribution of DM is sensitive to the distribution of baryons in galactic haloes, with viable gas profile models having significantly different probability distributions for DM to a given redshift. We also investigate the requirements to statistically measure the circumgalactic electron profile for FRB analyses that stack DM with impact parameter to foreground galaxies, quantifying the size of the contaminating ‘two-halo’ term from correlated systems and the number of FRBs for a high significance detection. Publicly available python modules implement our CGMBrush algorithm.
Expanded MutaT7 toolkit efficiently and simultaneously accesses all possible transition mutations in bacteria
Authors: Mengiste Amanuella A , Wilson Robert H , Weissman Rachel F , Papa III Louis J , Hendel Samuel J , Moore Christopher L , Butty Vincent L , Shoulders Matthew D 
Published: January 2023

AbstractTargeted mutagenesis mediated by nucleotide base deaminase–T7 RNA polymerase fusions has recently emerged as a novel and broadly useful strategy to power genetic diversification in the context of in vivo directed evolution campaigns. Here, we expand the utility of this approach by introducing a highly active adenosine deaminase–T7 RNA polymerase fusion protein (eMutaT7A→G), resulting in higher mutation frequencies to enable more rapid directed evolution. We also assess the benefits and potential downsides of using this more active mutator. We go on to show in Escherichia coli that adenosine deaminase-bearing mutators (MutaT7A→G or eMutaT7A→G) can be employed in tandem with a cytidine deaminase-bearing mutator (MutaT7C→T) to introduce all possible transition mutations simultaneously. We illustrate the efficacy of this in vivo mutagenesis approach by exploring mutational routes to antibacterial drug resistance. This work sets the stage for general application of optimized MutaT7 tools able to induce all types of transition mutations during in vivo directed evolution campaigns across diverse organisms.
Current advances in immunotherapy for atypical teratoid rhabdoid tumor (ATRT)
Authors: Tran Son , Plant-Fox Ashley S , Chi Susan N , Narendran Aru 
Published: January 2023

Abstract
Atypical teratoid rhabdoid tumors (ATRT) are rare and aggressive embryonal tumors of central nervous system that typically affect children younger than 3 years of age. Given the generally poor outcomes of patients with ATRT and the significant toxicities associated with conventional multi-modal therapies, there is an urgent need for more novel approaches to treat ATRT, one such approach being immunotherapy. The recent rise of large-scale, multicenter interdisciplinary studies has delineated several molecular and genetic characteristics unique to ATRT. This review aims to describe currently available data on the tumor immune microenvironment of ATRT and its specific subtypes and to summarize the emerging clinical and preclinical results of immunotherapy-based approaches. It will also highlight the evolving knowledge of epigenetics on immunomodulation in this epigenetically influenced tumor, which may help guide the development of effective immunotherapeutic approaches in the future.
A case of Ehlers–Danlos syndrome presenting as short stature: a novel mutation in SLC39A13 causing spondylodysplastic Ehlers–Danlos syndrome
Authors: Agrawal Poorvi , Kaur Harpreet , Kondekar Alpana , Rathi Surbhi 
Published: January 2023

Abstract
Ehlers–Danlos syndrome (EDS) is a heritable connective tissue disorder characterized by a varying degree of skin hyperextensibility and joint hypermobility. EDS is classified into 13 subtypes according to the most recent classification. These subtypes are clinically and genetically heterogenous. The spondylodysplastic subvariety of EDS (spEDS) is caused by homozygous mutations in B4GALT7, B3GALT6 and SLC39A13. To date, 13 individuals with molecularly diagnosed SLC39A13-related spEDS have been reported. The spEDS caused by biallelic pathogenic SLC39A13 variants are characterized by short stature, protuberant eyes with bluish sclera, finely wrinkled palms, hypermobile joints, hyperextensible skin and characteristic radiological findings. Herein, we report a case of 7-year-old-female child with spEDS associated with novel homozygous (pathogenic/likely pathogenic) missense variation of the SLC39A13 gene.
Observing thermal single-particle dynamics of ions and molecules in water with light
Authors: Aoki Kenichiro , Mitsui Takahisa 
Published: January 2023

Abstract
We observe thermal single-particle dynamics of ions and molecules in water through light extinction. The motions of particles appear as time-dependent intensity variations, characterized through their averaged spectra. The theoretical spectrum derived from random motions of one particle is found to describe the measured spectra. Since such spectra have not been observed previously and the corresponding theoretical formula is derived in this work, we obtain various physical properties from the observed spectra to corroborate our understanding of the phenomena. The diffusion constants of liquid mixtures and solutions, which correspond to binary diffusion and thermal diffusion, are extracted from the spectral measurements, and are found to be consistent with previous macroscopic measurements. We also estimate the sizes of the particles.
Reading Walter Scott’s Dramas
Authors: Cook Daniel 
Published: January 2023

Abstract
An active supporter of the theatre in Edinburgh and London, Walter Scott also extensively edited and commented on plays both ancient and modern. As a dramatist he wrote five original works, though he never achieved anything like the success he found with poetry and fiction. Only The House of Aspen, a Tragedy and Auchindrane; or, The Ayrshire Tragedy were staged, briefly, during the author’s lifetime. Written in collaboration with the actor Daniel Terry in 1817–1818, The Doom of Devorgoil, a Melo-drama was eventually rejected. Seemingly not even offered to theatres, Halidon Hill was published as a standalone work in 1822. A single-scene piece, Macduff’s Cross, appeared in a miscellany to fulfil an obligation to Joanna Baillie. Against the backdrop of Scott’s admitted failures as a dramatist, this essay examines the five playtexts in print, paying particular attention to different forms of residual theatricality still traceable in the works. Reading the plays entails due consideration of performance-focused paratexts, as well as scene divisions and speech prefixes, alongside a range of textual interruptions, emotionally descriptive stage directions, bookish motifs, and other print-centric devices.
Impact of a 24 h feed withdrawal on active nutrient transport, intestinal morphology and gene expression in the equine small and large intestine
Authors: Aldridge-Dean Blaire E , Lescun Timothy B , Radcliffe J Scott 
Published: January 2023

Abstract
Horses are often subjected to short term feed withdrawal (FW) pre- or post-surgery to reduce anesthetic complications. However, removing nutrients from the intestinal lumen may negatively impact intestinal health. Thirteen horses were used to determine the effects of a 24 h FW on gut barrier function, active nutrient transport, transporter gene expression and intestinal morphology. Following 0 or 24 h FW (0FW or 24FW, respectively), horses were euthanized via overdose of sodium- pentobarbital and –phenytoin, and segments of proximal jejunum (PJ), mid jejunum (MJ), ileum (Il) and right ventral colon (RVC) were harvested for histology (PJ and Il), gene expression, and active nutrient transport analysis. Active transport measurements were determined using modified Ussing chambers following the addition of glucose, phosphorus, glutamine and Gly-Sar. Carbachol induced chloride (Cl) ion secretion was measured to examine the diarrhetic response. Messanger RNA expression of the intestinal Na-dependent glucose cotransporter (SGLT1), fructose transporter (GLUT5), di- and tri-peptide transporter (PepT1) and neutral AA/glutamine transporter (ASCT2) were determined using RT-PCR. The GLM procedure of SAS was used to determine the effects of FW and responses among various intestinal sections. The horse served as the experimental unit. Villus heights (P &lt; 0.002) and crypt depths (P &lt; 0.02) in the Il were larger than in the PJ, though no differences were observed between 0FW and 24FW horses. Active glutamine absorption increased 82% in the PJ of 24FW horses compared to 0FW horses (P &lt; 0.02). The mRNA expression of SGLT1 decreased (P &lt; 0.05) moving aborally in the gastrointestinal tract. Horses subjected to 24FW had 82% less GLUT5 (P &lt; 0.05) and 61% less PepT1 mRNA expression in the PJ, compared to 0FW horses. Interestingly, ASCT2 mRNA expression increased 164% from PJ to RVC (P = 0.05). However, a 36% decrease in ASCT2 mRNA expression was observed overall for 24FW horses. This data indicates that SGLT1, GLUT5, PepT1 and ASCT2 are expressed throughout the small intestine and RVC of the horse at varying concentrations, and that they can be differentially regulated by a 24 h FW. Data from this experiment also indicates that a 24 h FW results in up regulation of active glutamine absorption, presumably in an effort to supply glutamine as an energy substrate for enterocytes.
Initiation and adherence to isoniazid preventive therapy in children under 5 years of age in Manhiça, Southern Mozambique
Authors: Montoya i de Manuel-Rimbau Agnès , Nguenha Dinis , Mambuque Edson , Ehrlich Joanna , Munguambe Shilzia , Saavedra Belén , Matsena Teodimiro , Chiconela Hélio , Casellas Aina , López-Varela Elisa , Acacio Sozinho , Garcia-Basteiro Alberto L 
Published: January 2023

Abstract
The WHO recommends preventive treatment for all pediatric contacts of a confirmed TB case, but coverage remains low in many high TB burden countries. We aimed to assess the coverage and adherence of the isoniazid preventive therapy (IPT) program among children under 5 years of age with household exposure to an adult pulmonary TB case in a rural district of Southern Mozambique. The estimated IPT coverage was 11.7%. A longer distance to the health center and lower age of the children hindered IPT initiation. Among patients who started IPT, 12/18 (69.9%) were adherent to the 6-month treatment.
Prognostic value of Intermountain Risk Score for short- and long-term mortality in patients with cardiogenic shock
Authors: Mert İlker Hayiroğlu , Faysal Saylik , Ahmet Çağdaş Yumurtaş , Murat Selçuk , Tufan Çinar 
Published: January 2023

Background
There is a lack of current research examining the predictive value of the Intermountain Risk Score (IMRS) in patients with ST-segment elevation myocardial infarction (STEMI) caused by cardiogenic shock. Therefore, the purpose of this research was to investigate the ability of IMRS to predict short- and long-term mortality in patients with cardiogenic shock triggered by STEMI.

Methods
The participants included 492 consecutive cardiogenic shock patients who underwent primary percutaneous coronary intervention following STEMI. The patients were separated into two groups depending on their survival status. The groups’ baseline characteristics, laboratory data, echocardiographic variables, and risk assessments were then compared. Next, the IMRS score was tested for its ability to predict both short- and long-term mortality. In order to assess its accuracy, the prognostic value of the IMRS was also compared that of the SYNTAX score II (SSII).

Results
After adjustment for the characteristics in the univariable study, multivariable Cox regression analysis indicated that the IMRS and SSII were both independently associated with short- and long-term mortality in STEMI patients with cardiogenic shock. However, the receiver operating characteristic curves indicated that the IMRS outperformed the SSII in terms of predicting both short- and long-term mortality.

Conclusion
This preliminary investigation showed that IMRS can predict both short- and long-term mortality in individuals with STEMI accompanied by cardiogenic shock.
Turkish Translation, Validation, and Reliability Analysis of Pediatric Eosinophilic Esophagitis Symptom Severity Module Version 2.0
Authors: Yilmaz Ozlem , Uslu Nuray Kizilkan , Ozgur Taner , Guller Dilek , Tumgor Gokhan , Usta Merve , Polat Esra , Ozkan Tanju Basarir , Baysoy Gokhan , Ugras Meltem Korkut , Baygul Arzu , Sackesen Cansin , Arikan Cigdem 
Published: January 2023

Objectives and study:
The Paediatric Eosinophilic Esophagitis Symptom Severity Modules Version 2.0 (T-PEESv2.0) was developed in English as a valid, reliable questionnaire for follow up. This work aimed to develop a Turkish version of T-PEESv2.0 via translation and cultural adaptation and then to test its validation and reliability.

Methods:
The PEESv2.0 was translated into Turkish by standardized procedural steps completed in cooperation with the Mapi Research Trust. The final version of the questionnaire was submitted to eosinophilic oesophagitis patients or their parents at 2 times point separated by 1 week. An age-matched control group was used to test the discriminant validity. Construct validity was tested using the Wilcoxon test, and internal consistency was tested using Cronbach’s alpha. Test-retest reliability was measured with Cohen’s kappa and intraclass correlation coefficient.

Results:
One hundred twenty-eight participants (70 patients, 58 parents) were enrolled. Fifty-eight (39.1%) of them completed T-PEESv2.0-parent by proxy and 70 (54.7%) were T-PEESv2.0. The Cronbach’s alpha coefficient and intraclass correlation coefficient for test-retest reliability were >0.70 for both questionnaires and for all domain (frequency and severity) and total scores. For discriminant validity analysis, subscale (frequency and domain) and total scores of the patient group were compared with those of the control group. The subscale and total scores were significantly different between the groups (P < 0.05).

Conclusion:
T-PEESv2.0 appeared to be valid and reliable, ready to be introduced as a clinical and research tool for the assessment of patients with eosinophilic oesophagitis.
Thermoelectric instabilities in a circular Couette flow
Authors: Meyer A. , Yoshikawa H. N. , Szabo P. S. B. , Meier M. , Egbers C. , Mutabazi I. 
Published: January 2023

The stability of a non-isothermal circular Couette flow is analyzed when subjected to a dielectrophoretic force field. Outward and inward heating configurations are considered when the inner cylinder is rotating and the outer cylinder is at rest. In addition, an alternating voltage is applied between the two cylinders to induce a radial electric buoyancy that acts on the dielectric fluid. The linear stability analysis provides the threshold for the first transition to instability, as well as the corresponding wavenumber and frequency of the modes.This article is part of the theme issue ‘Taylor–Couette and related flows on the centennial of Taylor’s seminalPhilosophical Transactionspaper (part 1)’.
Expecting the Unexpected: Predicting Panic Attacks from Mood and Twitter
Authors: McGinnis Ellen W. , Lunna Shania , Berman Isabel , Bagdon Skylar , Lewis Genevieve , Arnold Michael , Danforth Christopher M. , Dodds Peter Sheridan , Price Matthew , Copeland William E. , McGinnis Ryan S. 
Published: January 2023

AbstractBackgroundPanic attacks are an impairing mental health problem that affects about one in 10 US adults every year. Current DSM criteria describe panic attacks as unexpected, occurring without warning or triggering events. The unexpected nature of panic attacks not only leads to increased anxiety for the individual but has also made panic attacks particularly challenging to study. However, recent evidence suggests that individuals who experience such attacks could identify attack triggers.ObjectiveWe aimed to explore both retrospectively and prospectively, qualitative, and quantitative factors associated with the onset of panic attacks.MethodWe remotely recruited a diverse sample of 87 individuals who regularly experienced panic attacks from 30 states in the US. Participants responded to daily questions relating to their panic attacks and wellness behaviors each day for 28 days. We also considered daily community level factors captured by the Hedonometer, a metric which estimates population-level happiness daily using a random 10% of all public tweets.ResultsConsistent with our prior work, most participants (95%) were able to retrospectively identify a trigger for their attack. Worse individual mood was associated with greater likelihood of experiencing asame-daypanic attack over and above other individual wellness factors. Worse individually reported mood and state-based population level mood as indicated by the Hedonometer were associated with greater likelihood ofnext-daypanic attack.ConclusionsThese promising results suggest that individuals who experience panic attacks may be able to expect the unexpected. The importance of individual and state-based population level mood in panic attack risk could be used to ultimately inform future prevention and intervention efforts.
Adaptive vibration control method for double-crystal monochromator base on VMD and FxNLMS
Authors: Bai Yang , Gong Xuepeng , Lu Qipeng , Song Yuan , Zhu Wanqian , Xue Song , Wang Dazhuang , Peng Zhongqi , Zhang Zhen 
Published: January 2023

Double-crystal monochromators (DCMs) are one of the most critical optical devices in beamlines at synchrotron sources, directly affecting the quality of the beam energy and position. As the performance of synchrotron light sources continues to improve, higher demands are placed on the stability of DCMs. This paper proposes a novel adaptive vibration control method combining variational modal decomposition (VMD) and filter-x normalized least mean squares (FxNLMS), ensuring DCM stability under random engineering disturbance. Firstly, the sample entropy of the vibration signal is selected as the fitness function, and the number of modal components k and the penalty factor α are optimized by a genetic algorithm. Subsequently, the vibration signal is decomposed into band frequencies that do not overlap with each other. Eventually, each band signal is individually governed by the FxNLMS controller. Numerical results have demonstrated that the proposed adaptive vibration control method has high convergence accuracy and excellent vibration suppression performance. Furthermore, the effectiveness of the vibration control method has been verified with actual measured vibration signals of the DCM.
A theory-based approach to model entrepreneurial intentions: exploring the role of creativity, proactive personality and passion
Authors: Kumar Rakesh , Shukla Shalini 
Published: January 2023

PurposeThis study aims to examine the role of creativity and proactive personality to predict entrepreneurial intentions (EIs) using Ajzen’s (1991) theory of planned behaviour as an underpinning model. The study primarily focuses on how entrepreneurial self-efficacy and passion mediate the effect of creativity and proactive personality on EI.Design/methodology/approachA total of 531 college students of 18–28 years of age were surveyed using a structured questionnaire. The proposed model was tested using structural equation modelling in Amos 20.0, and the mediating effect of entrepreneurial self-efficacy and entrepreneurial passion was tested using the bootstrapping method.FindingsThe results validate the extension of the theory of planned behaviour to predict EIs and confirm that the effect of creativity and proactive personality on EIs through entrepreneurial self-efficacy was fully and partially mediated, respectively. Moreover, the relationship between entrepreneurial self-efficacy and the EI was partially mediated by entrepreneurial passion.Practical implicationsThe study provides a better understanding of college students' EI and identifies and highlights the role of social factors (i.e. subjective norms) and psychological factors such as attitude, self-efficacy, creativity, proactivity and passion in stimulating EIs. It deciphers the interlink of creativity, proactive personality, self-efficacy, passion and EIs. It may help academicians and policymakers better plan the educational programme to foster entrepreneurial instinct among students.Originality/valueThe study is a novel attempt to provide an integrated framework to explain EIs, highlighting the significance of creativity and proactive personality. It contributes to the existing literature by signifying the mediating role of entrepreneurial self-efficacy and passion.
A paradigm shift for medical health care to focus on a service-value approach to achieve greater patient satisfaction
Authors: Ali Naser , Dzandu Michael D. 
Published: January 2023

PurposeThis study takes a divergent approach to exploring which construct is more predictive of patient satisfaction (SAT) in a service dominant economy within the context of a healthcare setting.Design/methodology/approachApplying a critical analysis of literature, a service value (SV) model for customer SAT is proposed in this study, which is validated and confirmed with survey data from outpatients at Moorfields Eye Hospital – a world class specialist hospital based in the UK.FindingsQuality of service had the strongest impact on SV but SV had the strongest impact and mediation effect on patient SAT.Research limitations/implicationsThe study concludes that since SV rather than quality of service is more predictive of patient SAT, health service providers should focus more on SV in addition to quality of service, if they are to meet the dynamic expectations of their patients.Practical implicationsHealth service providers should focus more on SV in addition to quality of service, if they are to meet the dynamic expectations of their patients.Social implicationsThis poses a strong argument in favour of a paradigm shift in focus from quality of service-based model to service value-based model for greater patient satisfaction.Originality/valueThis is the first study exploring the inter-relationship of four constructs of patient SAT within the context of a leading major UK healthcare hospital service.