bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor Heterogeneity Confounds Lymphocyte Metrics in Diagnostic Lung Cancer Biopsies
Authors: Elfving Hedvig , Thurfjell Viktoria , Mattsson Johanna Sofia Margareta , Backman Max , Strell Carina , Micke Patrick 
Published: June 2023

Context.—
The immune microenvironment is involved in fundamental aspects of tumorigenesis, and immune scores are now being developed for clinical diagnostics.

Objective.—
To evaluate how well small diagnostic biopsies and tissue microarrays (TMAs) reflect immune cell infiltration compared to the whole tumor slide, in tissue from patients with non–small cell lung cancer.

Design.—
A TMA was constructed comprising tissue from surgical resection specimens of 58 patients with non–small cell lung cancer, with available preoperative biopsy material. Whole sections, biopsies, and TMA were stained for the pan-T lymphocyte marker CD3 to determine densities of tumor-infiltrating lymphocytes. Immune cell infiltration was assessed semiquantitatively as well as objectively with a microscopic grid count. For 19 of the cases, RNA sequencing data were available.

Results.—
The semiquantitative comparison of immune cell infiltration between the whole section and the biopsy displayed fair agreement (intraclass correlation coefficient [ICC], 0.29; P = .01; CI, 0.03–0.51). In contrast, the TMA showed substantial agreement compared with the whole slide (ICC, 0.64; P &lt; .001; CI, 0.39–0.79). The grid-based method did not enhance the agreement between the different tissue materials. The comparison of CD3 RNA sequencing data with CD3 cell annotations confirmed the poor representativity of biopsies as well as the stronger correlation for the TMA cores.

Conclusions.—
Although overall lymphocyte infiltration is relatively well represented on TMAs, the representativity in diagnostic lung cancer biopsies is poor. This finding challenges the concept of using biopsies to establish immune scores as prognostic or predictive biomarkers for diagnostic applications.
A reappraisal of the distribution of the Yellow-headed Manakin (Chloropipo flavicapilla) in Colombia and Ecuador
Authors: Palacio Rubén Darío 
Published: June 2023

The Yellow-headed Manakin (Chloropipo flavicapilla) is a rare and threatened species that is thought to occur between the Andes of Colombia and northeastern Ecuador. However, only three records support the presence of C. flavicapilla in Ecuador: a 19th-century specimen from Hacienda Mapoto, Tungurahua province, and two undocumented field observations from the early 1990s — one from Cordillera de Guacamayos and one from Volcán Sumaco. I investigated these records and found that the Mapoto specimen is a Green Manakin (Cryptopipo holochlora) deposited in the Museum and Institute of Zoology, Polish Academy of Sciences (MIZ 22050). The correct specimen identity was reported by Hellmayr (1929), but his notes were overlooked. The two undocumented sightings occurred in well-surveyed areas populated with eBird hotspots that are frequently visited by birders. Furthermore, there are no publicly available records of C. flavicapilla for these locations or anywhere else in Ecuador. Lastly, I analyzed the species distributional limits in southern Colombia. Two biogeographical barriers limit its distribution to northern Ecuador: (1) The Patía Valley in the western Andes and (2) the Colombian Massif in the central and eastern Andes. In conclusion, there is no tangible evidence that C. flavicapilla has been recorded in Ecuador, and based on its current distribution, it should be considered endemic to Colombia.
De l’Orient à l’Occident : migration et reterritorialisation identitaire chez Mahmud Nasimi
Authors: Zango Achille Carlos 
Published: June 2023

Cet article questionne la portée de la migration dans la reterritorialisation identitaire de Mahmud Nasimi à travers son récit Un Afghan à Paris (2021). En effet, à son arrivée dans la mythique ville de Paris, après avoir perçu dans la langue française un moyen de textualisation du parcours tumultueux subi depuis le départ de son pays d’origine, l’Afghanistan, jusqu’à celui d’accueil, la France, l’auteur a également trouvé dans cette langue un moyen de construction de son identité plurielle. Tout part de sa découverte de l’art européen et surtout de la littérature française qui deviendra pour lui la source du déclic de l’appropriation de l’ailleurs. Entre la terre d’origine secouée par des crises multiples, l’étranger s’impose finalement à l’auteur comme terre de reterritorialisation identitaire. En nous servant des approches autofictionnelle et intermédiale, ces lignes démontrent que l’écriture et la thématique d’Un Afghan à Paris sont l’expression de la rencontre entre deux aires culturelles : l’Occident et l’Orient.
Our Ancient Lakes
Authors: McKinnon Jeffrey 
Published: June 2023

The unexpected diversity, beauty, and strangeness of life in ancient lakes—some millions of years old—and the remarkable insights the lakes are yielding about the causes of biodiversity.
Most lakes are less than 10,000 years old and short-lived, but there is a much smaller number of ancient lakes, tectonic in origin and often millions of years old, that are scattered across every continent but Antarctica: Baikal, Tanganyika, Victoria, Titicaca, and Biwa, to name a few. Often these lakes are filled with a diversity of fish, crustaceans, snails, and other creatures found nowhere else in the world. In Our Ancient Lakes, Jeffrey McKinnon introduces the remarkable living diversity of these aquatic bodies to the general reader and explains the surprising, often controversial, findings that the study of their faunas is yielding about the formation and persistence of species.
The first single-authored volume to synthesize studies of ancient lakes, Our Ancient Lakes provides an overview of the lakes and their distinctive geological origins; accounts of the evolutionary processes that have generated the incredible diversity found in the lakes and produced some of the fastest speciation rates known for vertebrates; the surprisingly important role of interspecies mating in the most rapid diversifications; the uniquely complete records of the creatures that inhabited the lakes, which are being extracted from deep lake sediments; the prospects for the lakes as we tumble into the Anthropocene; and much more.
Shining a light on a class of biodiversity hot spot that is equivalent to coral reefs in the ocean or tropical rainforests on land, Our Ancient Lakes chronicles in a refreshingly personal and accessible way the often singular wonders of these venerable water bodies.
The MIT Press gratefully acknowledges Furthermore: a program of the J.M. Kaplan Fund.
Memory, Edited
Authors: Rumsey Abby Smith 
Published: June 2023

An exploration of historical memory and networks of meaning in the context of today's crises of extremism and polarization.
As authoritarianism continues to rise around the world, the stories we tell ourselves about what has happened and what is happening become ever more relevant. In Memory, Edited, Abby Smith Rumsey examines collective memory, how it binds us, and how it can be used by bad actors to manipulate us. Bringing forward the voices of a rich cast of Eastern European artists from the past two hundred years—from Fyodor Dostoevsky to Gerhard Richter—Rumsey shows how their work and lives illustrate the devastation wrought by regimes dependent on entrenched lies to survive. This hijacking of the narrative polarizes communities even as it commandeers our future.
Through an interdisciplinary lens that includes the best thinking from history, the arts, cognitive science, psychology, and political philosophy, Rumsey lays bare our narratives, showing how they are constructed and how they have changed over time. Ever-aware of resisting the false promise of utopia, Rumsey argues that only by confronting the past and reckoning with the crimes that were committed can we ever hope to heal and gain self-knowledge. Memory, Edited is an indispensable text for anyone who cares about democracy, equality, and freedom in our current age of crisis.
Sculptor and Destroyer
Authors: Mattson Mark P. 
Published: June 2023

The fascinating story of glutamate, the neurotransmitter that controls the structure and function of the brain in health and neurological disorders.
Sculptor and Destroyer tells the story of a simple, little-known molecule that became a master architect and commander of the human brain: glutamate. Upward of 90 percent of the neurons in the human brain deploy glutamate as their neurotransmitter. Other neurotransmitters can only exert their effects on brain function by subtly modifying the ongoing activity of glutamatergic neurons, but during brain development glutamate controls the growth of dendrites and the formation of synapses. In this eye-opening book, Mark Mattson explains how the neurotransmitter glutamate controls the structure and function of neuronal networks in the brain, thereby mediating the brain's capabilities, including learning and memory, creativity, and imagination.
Mattson also delves deeply into the dark side of glutamate, which he calls the “destroyer” side. He shows how relatively subtle aberrancies in the activity of neurons that deploy glutamate may result in behavioral disorders ranging from autism and schizophrenia to chronic anxiety and depression. More dramatically, he describes how glutamate can excite neurons to death, a process that occurs in epilepsy and stroke and, perhaps even more insidiously, in Alzheimer's disease, Parkinson's disease, ALS, and Huntington's disease. Sculptor and Destroyer concludes with a perspective on how knowledge of glutamate's roles in neuroplasticity might be applied to the optimization of brain health throughout our lives.
Written inengaging, approachable prose, Sculptor and Destroyer will be of interest to anyone in the fields of neuroscience, neurology, psychiatry, and psychology, as well as to anyone with a curiosity about the human brain.
Plastics
Authors: Walker-Franklin Imari , Jambeck Jenna 
Published: June 2023

A comprehensive introduction to the plastics life cycle—the impacts on our lives, our future, and our planet—and the actions we can take.
Everywhere we look, we are surrounded by plastics: perhaps you have a book in one hand and your phone—made of various metals, plastics, and glass—in the other, or you are reading this on your polyurethane mattress after having flipped on a plastic light switch. In this Essential Knowledge series volume, Imari Walker-Franklin and Jenna Jambeck provide a deep exploration of the entire life of plastic things—plastics production and use, plastic waste generation and management, the environmental and societal impacts of plastics in our environment, and, finally, the policies that can help reduce pollution caused by our heavy use of plastics.
One of the most current and comprehensive summaries on the subject, Plastics covers not only ocean and terrestrial plastic pollution but also the potential harms of microplastics on the human body. The authors also explain why we use plastic for so many products, how trash ends up in even the most remote corners of our world, and the alternatives and interventions that can help address our overreliance on this virtually imperishable material. As easily digestible to read as it is important, this book empowers its readers with the crucial knowledge and information they need to make thoughtful consumer choices, influence change, and spark inspiration.
Lifelines of Our Society
Authors: van Laak Dirk 
Published: June 2023

A comprehensive history and examination of global infrastructures and the outsized role they play in our lives.
Infrastructure is essential to defining how the public functions, yet there is little public knowledge regarding why and how it became today's strongest global force over government and individual lives. Who should build and maintain infrastructures? How are they to be protected? And why are they all in such bad shape? In Lifelines of Our Society, Dirk van Laak offers broad audiences a history of global infrastructures—focused on Western societies, over the past two hundred years—that considers all their many paradoxes. He illustrates three aspects of infrastructure: their development, their influence on nation building and colonialism, and finally, how individuals internalize infrastructure and increasingly become not only its user but regulator.
Beginning with public works, infrastructure in the nineteenth century carried the hope that it would facilitate world peace. Van Laak shows how, instead, it transformed to promote consumerism's individual freedoms and our notions of work, leisure, and fulfillment. Lifelines of Our Society reveals how today's infrastructure is both a source and a reflection of concentrated power and economic growth, which takes the form of cities under permanent construction. Symbols of power, van Laak describes, come with vulnerability, and this book illustrates the dual nature of infrastructure's potential to hold nostalgia and inspire fear, to ease movement and govern ideas, and to bring independence to the nuclear family and control governments of the Global South.
Notebooks of a Wandering Monk
Authors: Ricard Matthieu 
Published: June 2023

The memoirs of renowned Buddhist monk Matthieu Ricard and his extraordinary journey toward inner freedom and compassion in action.
Matthieu Ricard began his spiritual transformation at the age of twenty-one, in Darjeeling, India, when he met Tibetan teacher Kangyur Rinpoche, who deeply impressed the young man with his extraordinary quality of being. In Notebooks of a Wandering Monk, Ricardtells the simple yet extraordinary story of his journey and the remarkable men and women who inspired him along the way, including Kangyur Rinpoche, Dilgo Khyentse Rinpoche, and the fourteenth Dalai Lama, as well as great luminaries such as Desmond Tutu, Jane Goodall, and a number of leading scientists.
Growing up, Ricard, the son of philosopher Jean-François Revel and artist Yahne Le Toumelin, regularly found himself in the company of intellectuals and artists such as Luis Buñuel, Henri Cartier-Bresson, and Igor Stravinsky. Young Ricard loved nature, classical music, and science and dreamed of unlocking the mysteries of molecular biology. But, six years after meeting Kangyur Rinpoche, Ricard gave up a promising career in genetics to pursue a meditative life in the remote Himalayas. While spending half a century in India, Bhutan, and Nepal, he visited Tibet more than twenty times and spent years publishing rare Tibetan texts and photographing his spiritual teachers and the world in which they lived.
Elegantly translated by Jesse Browner and accompanied by more than fifty full-color photographs, many of which are Ricard's own, Notebooksof a Wandering Monk charts Ricard's lifelong path to wisdom and compassion. This candid and reflective memoir will inspire all readers, wherever they may be on their own journey to a meaningful and well-lived life.
On Disinformation
Authors: McIntyre Lee 
Published: June 2023

A powerful, pocket-sized citizen's guide on how to fight back against the disinformation campaigns that are imperiling American democracy, from the bestselling author of Post-Truth and How to Talk to a Science Denier.
The effort to destroy facts and make America ungovernable didn't come out of nowhere. It is the culmination of seventy years of strategic denialism. In On Disinformation, Lee McIntyre shows how the war on facts began, and how ordinary citizens can fight back against the scourge of disinformation that is now threatening the very fabric of our society. Drawing on his twenty years of experience as a scholar of science denial, McIntyre explains how autocrats wield disinformation to manipulate a populace and deny obvious realities, why the best way to combat disinformation is to disrupt its spread, and most importantly, how we can win the war on truth.
McIntyre takes readers through the history of strategic denialism to show how we arrived at this precarious political moment and identifies the creators, amplifiers, and believers of disinformation. Along the way, he also demonstrates how today's “reality denial” follows the same flawed blueprint of the “five steps of science denial” used by climate deniers and anti-vaxxers; shows how Trump has emulated disinformation tactics created by Russian and Soviet intelligence dating back to the 1920s; provides interviews with leading experts on information warfare, counterterrorism, and political extremism; and spells out the need for algorithmic transparency from Facebook, Twitter, and YouTube. On Disinformation lays out ten everyday practical steps that we can take as ordinary citizens—from resisting polarization to pressuring our Congresspeople to regulate social media—as well as the important steps our government (if we elect the right leaders) must take.
Compact, easy-to-read (and then pass on to a friend), and never more urgent, On Disinformation does nothing less than empower us with the tools and knowledge needed to save our republic from autocracy before it is too late.
Racism Untaught
Authors: Mercer Lisa E. , Moses Terresa 
Published: June 2023

A powerful and proven guidebook that shows organizations how to recognize racism in designed artifacts, systems, and experiences—and how to replace them with anti-racist design solutions.
Anti-racist design interventions can be difficult. Well-intentioned conversations can fuel tensions, activate racialized trauma, and lead to misunderstandings, especially in spaces not typically focused on diversity, equity, and inclusion. Even when progress is made, white supremacy culture can resurface. We need anti-racist guidelines and approaches that lay bare racialized systems of oppression and fundamentally disrupt their replication. In Racism Untaught, Lisa E. Mercer and Terresa Moses, two veteran anti-racist educators, deliver this exact approach.
Mercer and Moses provide a step-by-step guide to anti-racist interventions in academic, business, and community settings that benefits all participants. Adapted from their successful workshop series and filled with concrete examples and ample case studies, their book teaches participants how to analyze design—and reimagine racialized artifacts, systems, and experiences guided by anti-oppressive principles. They demonstrate how to examine positionality within the context of racism and oppression; help us understand how design can reinforce and perpetuate oppression; and reveal the unique relationship among equity, ethics, and responsibility that constitutes the core value of an anti-racist design discipline. In Racism Untaught, Mercer and Moses provide the framework we need to unlearn racialized design practices and move more generatively toward collective liberation.
With a foreword by renowned designer Cheryl D. Miller, Racism Untaught is a valuable tool for anyone who wants to help themselves and their organization create an actionable and inclusive plan to dismantle racial oppression and instead realize equitable, anti-racist, and liberatory design.
Hvordan påvirkes bunnfauna i en nordnorsk fjord av avgangsmasser fra en kobbergruve?
Authors: Evenset Anita , Renaud Paul E. , Trannum Hilde C. , Christensen Guttorm N. , Pedersen Kristine B. 
Published: June 2023

Norge er en av få nasjoner i verden som tillater undersjøisk deponering av avgangsmasser fra gruvedrift. Tidligere tiders filosofi basert på "ute av syne, ute av sinn" er imidlertid ikke et argument som fungerer i dagens samfunn. Det har derfor vært et sterkt fokus på kunnskapsinnhenting knyttet til hvordan slik deponering påvirker marint miljø de senere år.
Balance and Genetic Mechanisms in the COVID-19 Process of Mutation
Authors: Valdovinos Alejandro Coutiño , Gaitan Indira Vega , Guerrero Beatriz Garnica , Vega Iracema Islas , Vázquez Josefina Reynoso , Ledezma Jesús Carlos Ruvalcaba 
Published: June 2023

Introduction: SRAS-Cov-2, First found on December 2019 in Wuhan China has turned into a worldwide health care problem. The changes on genetic drift, genetic recombination, natural selection, and other mutations originated variants of medical concern because of the changes on its transmissibility, pathogenesis, or its capacity to avoid the immune system. This is mainly because of the mutations on the structural proteins as the spike protein.
Objective: Describe the COVID-19 mechanisms of mutation.
Methodology: A systematic review was carried out, the search for information was carried out in journals indexed in (Crossref, Google Scholar, SciELO, and in Journals indexed in SCIE, SSCI, ESCI) using keywords; COVID-19 genome, COVID-19 mutations, COVID-19 variants.
Results: The main mutations among COVID-19 variants are due to the Spike protein in its N501Y and D614G forms and modifying the N-terminal domain; likewise, there are mutations in the other structural proteins M, E and N and in the ORF1a and b regions. It has been shown to be multifactorial as it is influenced to mutate by environmental factors.
Conclusions: A detailed comparison was made of the main pathogenic and genetic characteristics of the variants of medical importance in the COVID-19 pandemic. It has been shown to be multifactorial as it is influenced to mutate by environmental factors. For this reason, it is important the correct execution of public health and the application of programs focused on the prevention of contagion and improvement of habits and care to avoid the evolution of the pathogenesis of the virus.
Effect of Cell Free Microbial Bio-Stimulant on Growth, Yield and the Microbial Activity of Tomato (Solanum lycopersicum L.) Grown in Vertisol
Authors: Kumar Devendra , Baghel Dayashankar , Banwasi Rakesh , Singh Anup Kumar , Soni Ravindra 
Published: June 2023

A field experiment was conducted to find out the effect of a cell-free microbial biostimulant on growth, yield, and the microbial activity of tomato (Solanum lycopersicum L.) grown in a field during the rabi season (December–April) of 2021–22 at the Instructional Cum Research Farm, College of Agriculture, IGKV, Raipur, Chhattisgarh, India. Pant-3 variety of tomato was used for the experiment, which was spaced in 45×60 cm. The experiment consists of seven treatments, viz., six levels of cell-free microbial bio-stimulant (control, 0.125 L ha-1, 0.25 L ha-1, 0.50 L ha-1, 0.63 L ha-1, 1.25 L ha-1, and 2.50 L ha-1), in combination with 100% Recommended dose of fertilizer (RDF), and was laid out in a randomised block design (RBD) with three replications. Data regarding the height of the plant, numbers of fruits (plant-1), yield (kg ha-1), dehydrogenase, and microbial activity were observed. The experimental result revealed that the application of a cell-free microbial bio-stimulant with a combination of 100% RDF was found to have a significant impact on the microbial population and dehydrogenase activity of soil, but that plant height, fruit number, and yield were not significantly affected. According to the performance of the crop and analysis of rhizosphere soil, it can be concluded that the cell-free microbial bio-stimulant @ 2.50 L ha-1 with soil application along with 100% RDF (120:80:80 kg ha-1 N:P:K) increases the soil microbial population, i.e., bacteria, actinomycetes, and fungi, and also improves the quality of the soil.