bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduction in genital sexual arousal varies by type of oral contraceptive pill
Authors: Handy Ariel B , McMahon Leah N , Goldstein Irwin , Meston Cindy M 
Published: June 2023

AbstractBackgroundAlthough oral contraceptive pills (OCPs) have been associated with decrements in self-reported genital arousal and vaginal lubrication, 1,2 little is known about how these outcomes vary across types of OCPs.AimThe present study examined differences in physiological lubrication and vaginal blood flow, as well as rates of self-reported vulvovaginal atrophy and female sexual arousal disorder, among women using OCPs with varying androgenic properties.MethodsParticipants in this study were 130 women: 59 naturally cycling control women, 50 women taking androgenic OCPs, and 21 women taking antiandrogenic OCPs. Participants watched sexual films while their sexual arousal responses were measured, completed questionnaires, and participated in a clinical interview.OutcomesVaginal blood flow, vaginal lubrication, self-reported vulvovaginal atrophy, and female sexual arousal disorder were assessed.ResultsResults indicated deficits in vaginal pulse amplitude and lubrication for women taking either form of OCP, with marked inhibitory effects found in women taking antiandrogenic OCPs. Rates of self-reported vulvovaginal atrophy and female sexual arousal disorder were also significantly greater in the antiandrogenic group compared with the control group.Clinical ImplicationsIt is recommended that prescribing clinicians consult patients on such physiological effects of OCPs.Strengths and LimitationsTo our knowledge, this was the first study to compare multiple measures of physiological sexual arousal across groups of women taking OCPs with varying hormonal profiles. Because all OCPs included in this study contained low doses of ethinylestradiol, we were able to identify the specific effects of the androgenic properties on women’s sexual arousal responses. However, the self-administered lubrication test strip was subject to user error. Additionally, the generalizability of findings is limited by the largely heterosexual and college-aged sample.ConclusionCompared with naturally cycling women, women taking OCPs that contain antiandrogenic progestins experienced decreased vaginal blood flow and lubrication as well as higher rates of self-reported vaginal bleeding and female sexual arousal disorder.
Post-acute sequelae of COVID-19 in older persons: multi-organ complications and mortality
Authors: Wan Eric Yuk Fai , Zhang Ran , Mathur Sukriti , Yan Vincent Ka Chun , Lai Francisco Tsz Tsun , Chui Celine Sze Ling , Li Xue , Wong Carlos King Ho , Chan Esther Wai Yin , Lau Chak Sing , Wong Ian Chi Kei 
Published: June 2023

Abstract

Introduction
Evidence on long-term associations between coronavirus disease 2019 (COVID-19) and risks of multi-organ complications and mortality in older population is limited. This study evaluates these associations.

Research design and methods
The cohorts included patients aged ≥60 year diagnosed with COVID-19 infection (cases), between 16 March 2020 and 31 May 2021 from the UK Biobank; and between 01 April 2020 and 31 May 2022 from the electronic health records in Hong Kong. Each patient was randomly matched with individuals without COVID-19 infection based on year of birth and sex and were followed for up to 18 months until 31 August 2021 for UKB, and up to 28 months until 15 August 2022 for HK cohort. Patients with COVID-19 infection over 6 months after the date of last dose of vaccination and their corresponding controls were excluded from our study. Characteristics between cohorts were further adjusted with Inverse Probability Treatment Weighting. For evaluating long-term association of COVID-19 with multi-organ disease complications and mortality after 21-days of diagnosis, Cox regression was employed.

Result
10,759 (UKB) and 165,259 (HK) older adults with COVID-19 infection with matched 291,077 (UKB) and 1,100,394 (HK) non-COVID-19-diagnosed older adults were recruited. Older adults with COVID-19 were associated with a significantly higher risk of cardiovascular outcomes [major cardiovascular disease (stroke, heart failure and coronary heart disease): hazard ratio(UKB): 1.4 (95% Confidence interval: 1.1,1.6), HK:1.2 (95% CI: 1.1,1.3)]; myocardial infarction: HR(UKB): 1.8 (95% CI: 1.3,2.4), HK:1.2 (95% CI: 1.0,1.4)]; respiratory outcomes [interstitial lung disease: HR(UKB: 3.4 (95% CI: 2.5,4.5), HK: 4.0 (95% CI: 1.3,12.8); chronic pulmonary disease: HR(UKB): 1.7 (95% CI: 1.3,2.2), HK:1.6 (95% CI: 1.3,2.1)]; neuropsychiatric outcomes [seizure: HR(UKB): 2.6 (95% CI: 1.7,4.1), HK: 1.6 (95% CI: 1.2,2.1)]; and renal outcomes [acute kidney disease: HR(UKB): 1.4 (95% CI: 1.1,1.6), HK:1.6 (95% CI: 1.3,2.1)]; and all-cause mortality [HR(UKB): 4.9 (95% CI: 4.4,5.4), HK:2.5 (95% CI: 2.5,2.6)].

Conclusion
COVID-19 is associated with long-term risks of multi-organ complications in older adults (aged ≥ 60). Infected patients in this age-group may benefit from appropriate monitoring of signs/symptoms for developing these complications.
Meyer Schapiro, the Jewish Museum, and Living Artists: A Scholar’s Overlooked Activism
Authors: Abt Jeffrey 
Published: June 2023

Abstract
Meyer Schapiro was among a handful of New York’s most prominent Jewish thinkers writing about modern art during the post-Second World War period, just as the international center of new art had shifted there from Paris. Unlike his contemporaries Clement Greenberg and Harold Rosenberg, however, Schapiro is thought to have “seldom” or only “subliminally” addressed questions of Jewish identity, suggesting that he avoided or suppressed the matter. Yet his nearly four-decade-long relationship with the Jewish Museum of New York tells a different story. Schapiro’s unpublished correspondence, memoranda, and addresses reveal his role in transforming the Jewish Museum into a venue for avant-garde art and his urging Jewish acceptance of modern art, including works that were not visibly Jewish or that were created by non-Jews. These efforts reflect the ways his kinship with the Jewish community prompted his articulation of universal values of humanitarianism and social justice that he associated with Judaism, values that coincided with his social activism. The archival materials also show how Schapiro engaged with questions of Jewish identity as he drew on his scholarly knowledge and his affinity with the Jewish community to further the appreciation of modern art for the benefit of Jewish and non-Jewish artists and audiences.
A crystallizing white dwarf in a sirius-like quadruple system
Authors: Venner Alexander , Blouin Simon , Bédard Antoine , Vanderburg Andrew 
Published: June 2023

ABSTRACT
The observational signature of core crystallization of white dwarfs has recently been discovered. However, the magnitude of the crystallization-powered cooling delay required to match observed white dwarfs is larger than predicted by conventional models, requiring additional mechanisms of energy release in white dwarf interiors. The most ideal benchmarks for understanding this discrepancy would be bright and nearby crystallizing white dwarfs with total ages that can be externally constrained. In this work, we report that a recently discovered white dwarf is a bound companion to the triple star HD 190412, forming a new Sirius-like system in the solar neighbourhood. The location of HD 190412 C on the Teff − mass diagram implies it is undergoing crystallization, making this the first confirmed crystallizing white dwarf whose total age can be externally constrained. Motivated by the possibility that a cooling delay caused by crystallization can be directly detected for this white dwarf we employ a variety of methods to constrain the age of the system; however, our empirical age anomaly of +3.1 ± 1.9 Gyr is ultimately too imprecise to reach statistical significance, preventing us from making strong constraints to models of white dwarf crystallization. Our results are none the less compatible with the recent hypothesis that 22Ne phase separation is responsible for the excess cooling delay of crystallizing white dwarfs. The discovery of this system at only 32 parsecs suggests that similar benchmark systems are likely to be common; future discoveries may therefore provide powerful tests for models of white dwarf crystallization.
Discovery of magnetospheric interactions in the doubly magnetic hot binary ϵ Lupi
Authors: Biswas Ayan , Das Barnali , Chandra Poonam , Wade Gregg A , Shultz Matthew E , Cavallaro Francesco , Petit Veronique , Woudt Patrick A , Alecian Evelyne 
Published: June 2023

ABSTRACT
Magnetic fields are extremely rare in close, hot binaries, with only 1.5 per cent of such systems known to contain a magnetic star. The eccentric ϵ Lupi system stands out in this population as the only close binary in which both stars are known to be magnetic. We report the discovery of strong variable radio emission from ϵ Lupi using the upgraded Giant Metrewave Radio Telescope (uGMRT) and the MeerKAT radio telescope. The light curve exhibits striking unique characteristics including sharp high-amplitude pulses that repeat with the orbital period, with the brightest enhancement occurring near periastron. The characteristics of the light curve point to variable levels of magnetic reconnection throughout the orbital cycle, making ϵ Lupi the first known high-mass, main sequence binary embedded in an interacting magnetosphere. We also present a previously unreported enhancement in the X-ray light curve obtained from archival XMM–Newton data. The stability of the components’ fossil magnetic fields, the firm characterization of their relatively simple configurations, and the short orbital period of the system make ϵ Lupi an ideal target to study the physics of magnetospheric interactions. This system may thus help us to illuminate the exotic plasma physics of other magnetically interacting systems such as moon–planet, planet–star, and star–star systems including T Tauri binaries, RS CVn systems, and neutron star binaries.
TRLS-05. PRELIMINARY RESULTS FROM A PHASE I TRIAL TO EVALUATE INTRAVENTRICULAR DELIVERY OF IL13RΑ2-TARGETING CAR T CELLS AFTER LYMPHODEPLETION IN PEDIATRIC BRAIN TUMORS PATIENTS
Authors: Davidson Tom , Oill Angela , Wu Melody , Egelston Colt , Natri Heini , Sepulveda Sean , Hibbard Jonathan , Wagner Jamie , Nisis Monica , Kilpatrick Julie , Stiller Tracey , Georges Joseph , Munoz Margarita , Oliver-Cervantes Cheryl , Shepphird Jennifer , Ressler Julie , D’Apuzzo Massimo , Aftabizadeh Maryam , Blanchard M Suzette , Badie Behnam , Brown Christine , Banovich Nicholas , Wang Leo 
Published: June 2023

Abstract
Brain tumors are the leading cause of cancer death in children, and outcomes for patients with recurrent or aggressive disease remain poor. We have previously shown that locoregionally-delivered chimeric antigen receptor (CAR) T cells targeting the high-affinity IL13 receptor IL13Rα2 are safe and well-tolerated in adults, and that they can mediate a remarkable clinical response. This antigen is also expressed on roughly half of pediatric neuromalignancies. Here, we present the clinical experience from the first patients treated with IL13BBζ-CAR T cells on our trial. Patients received four doses of CAR T cells, delivered weekly through an indwelling CNS catheter; the first dose was 1e7 CAR T cells and subsequent doses were 5e7 cells. The first three patients received CAR T cells alone; the rest received lymphodepletion with cyclophosphamide and fludarabine before CAR T cell infusion. After follow-up imaging at the end of the dose-limiting toxicity (DLT) period, patients were given the option to continue therapy. Six patients have been treated without DLTs; one patient on the lymphodepletion arm did not complete the four infusions due to a Grade 3 catheter-related infection. Other patients experienced occasional Grade 3 AEs that were not attributed to CAR T therapy, with the exception of headache, muscle weakness, and ALT elevation. Otherwise, AEs were Grade 1-2. Five patients completed four infusions and were evaluable at the end of the DLT period. Of those, three experienced radiographic and/or clinical benefit, although none met protocol criteria for a partial response. Specific cytokines were increased in the cerebrospinal fluid (CSF) of patients during radiographic response periods. Additionally, single-cell transcriptomic analysis paired with TCR sequencing of CSF cells demonstrated characteristic immune signatures correlated with response. These preliminary results support combining lymphodepletion and repeated intraventricular CAR T cell delivery as a promising therapy in children with brain tumors.
CO multi-line imaging of nearby galaxies (COMING). XII. CO-to-H2 conversion factor and dust-to-gas ratio
Authors: Yasuda Atsushi , Kuno Nario , Sorai Kazuo , Muraoka Kazuyuki , Miyamoto Yusuke , Kaneko Hiroyuki , Yajima Yoshiyuki , Tanaka Takahiro , Morokuma-Matsui Kana , Takeuchi Tsutomu T , Kobayashi Masato I N 
Published: June 2023

Abstract
We simultaneously measured the spatially resolved CO-to-H2 conversion factor (αCO) and dust-to-gas ratio (DGR) in nearby galaxies on a kiloparsec scale. In this study, we used 12CO(J = 1–0) data obtained by the Nobeyama 45 m radio telescope with H i and dust mass surface densities. We obtained the values of global αCO and DGR in 22 nearby spiral galaxies, with averages of 2.66 ± 1.36 M⊙ pc−2 (K km s−1)−1 and 0.0052 ± 0.0026, respectively. Furthermore, the radial variations of αCO and DGR in four barred spiral galaxies (IC 342, NGC 3627, NGC 5236, and NGC 6946) were obtained by dividing them into inner and outer regions with a boundary of 0.2 R25, where R25 is the isophotal radius at 25 mag arcsec−2 in the B band. The averages of αCO and DGR in the inner region (≤0.2 R25) are 0.36 ± 0.08 M⊙ pc−2 (K km s−1)−1 and 0.0199 ± 0.0058, while those in the outer region (&gt;0.2 R25) are 1.49 ± 0.76 M⊙ pc−2 (K km s−1)−1 and 0.0084 ± 0.0037, respectively. The value of αCO in the outer region is 2.3 to 5.3 times larger than that of the inner region. When separated into the inner and outer regions, we find that αCO and DGR correlate with the metallicity and the star formation rate surface density. The value of αCO derived in this study tends to be smaller than those obtained in previous studies for the Milky Way and nearby star-forming galaxies. This fact can be attributed to our measurements being biased toward the inner region; we measured αCO at 0.85 and 0.76 times smaller in radius than the previous works for nearby star-forming galaxies and the Milky Way, respectively.
On the well-posed variational principle in degenerate point particle systems using embeddings of the symplectic manifold
Authors: Tomonari Kyosuke 
Published: June 2023

Abstract
A methodology on making the variational principle well-posed in degenerate systems is constructed. In the systems including higher-order time derivative terms being compatible with Newtonian dynamics, we show that a set of position variables of a coordinate system of a given system has to be fixed on the boundaries and that such systems are always Ostrogradski stable. For these systems, Frobenius integrability conditions are derived in explicit form. Relationships between integral constants indicated from the conditions and boundary conditions in a given coordinate system are also investigated by introducing three fundamental correspondences between Lagrange and Hamilton formulation. Based on these ingredients, we formulate problems that have to be resolved to realize the well-posedness in the degenerate systems. To resolve the problems, we compose a set of embeddings that extract a subspace holding the symplectic structure of the entire phase space in which the variational principle should be well-posed. Using these embeddings, we establish a methodology to set appropriate boundary conditions that the well-posed variational principle demands. Finally, we apply the methodology to examples and summarize this work as a three-step procedure such that one can use just by following it.
Non-SUSY lepton flavor model with the three Higgs doublet model
Authors: Izawa Yukimura , Shimizu Yusuke , Takei Hironori 
Published: June 2023

Abstract
We propose a simple non-supersymmetric lepton flavor model with A4 symmetry. The A4 group is a minimal one that includes triplet irreducible representation. We introduce three Higgs doublets, which are assigned as a triplet of the A4 symmetry. It is natural that there are three generations of the Higgs fields, as with the standard model fermions. We analyze the potential and find the vacuum expectation values for the local minimum. In the vacuum expectation values, we obtain the charged lepton, Dirac neutrino, and right-handed Majorana neutrino mass matrices. By using the type-I seesaw mechanism, we get the left-handed Majorana neutrino mass matrix. In the NuFIT 5.1 data, we predict the Dirac CP phase and the Majorana phases for the only inverted neutrino mass hierarchy. In particular, the Dirac CP phase and lepton mixing angle θ23 are strongly correlated. If θ23 is more precisely measured, the Dirac CP phase is more precisely predicted, and vice versa. We also predict the effective mass for neutrinoless double beta decay mee ≃ 47.1 [meV] and the lightest neutrino mass m3 ≃ 0.789–1.43 [meV]. This will be testable with our model in near-future neutrino experiments.
Three instability stratifications of the stack of Higgs bundles on a smooth projective curve
Authors: Hamilton Eloise 
Published: June 2023

Abstract
We study three instability stratifications of the stack of twisted Higgs bundle of a fixed rank and degree on a smooth complex projective curve. The first is the Harder–Narasimhan (HN) stratification, defined by the instability type of the Higgs bundle. The second is the bundle Harder–Narasimhan (bHN) stratification, defined by the instability type of the underlying bundle. While an unstable HN stratum fibres over the stack parameterizing Higgs bundles which are isomorphic to their HN graded, this is not true for Higgs bundles of unstable bHN type. Obtaining such a fibration requires refining the bHN stratification; this is the third instability stratification. After introducing these three stratifications, we establish comparison results. In particular, we obtain explicit criteria for determining semistability of a Higgs bundle of low rank with unstable underlying bundle. Then we show how the HN and bHN stratifications can be used to filter the stack of Higgs bundles by global quotient stacks in two different ways. Finally, we use these filtrations to relate the HN and bHN stratifications to GIT instability stratifications and the refined bHN stratification to a Bialynicki–Birula stratification.
Early Outcomes of Operative Versus Nonoperative Management of Stress-Positive Minimally Displaced Lateral Compression Type 1 Pelvic Ring Injuries
Authors: Tucker Nicholas J. , Scott Bryan L. , Heare Austin , Stacey Stephen , Mauffrey Cyril , Parry Joshua A. 
Published: June 2023

Objectives:
To compare the early outcomes of patients with stress-positive minimally displaced lateral compression type 1 (LC1b) pelvic ring injuries managed with or without operative fixation.

Design:
Retrospective comparison study.

Setting:
Level 1 trauma center.

Patients/Participants:
Forty-three patients with LC1b injuries.

Intervention:
Operative versus nonoperative.

Main Outcome Measurements:
Discharge to subacute rehabilitation (SAR); 2- and 6-week pain visual analog score, opioid use, assistive device use, percentage of normal single assessment numerical evaluation, SAR status; fracture displacement; and complications.

Results:
The operative group did not differ in age, gender, body mass index, high-energy mechanism, dynamic displacement stress radiographs, complete sacral fractures, Denis sacral fracture classification, Nakatani rami fracture classification, follow-up length, or American Society of Anesthesiologists classification. The operative group was less likely to be using an assistive device at 6 weeks [observed difference (OD) −53.9%, 95% confidence interval (CI) −74.3% to −20.6%, OD/CI 1.00, P = 0.0005], less likely to remain in an SAR at 2 weeks (OD −27.5%, CI, −50.0% to −2.7%, OD/CI 0.58, P = 0.02), and had less fracture displacement at follow-up radiographs (OD −5.0 mm, CI, −9.2 to −1.0 mm, OD/CI 0.61, P = 0.02). There were no other differences in outcomes between treatment groups. Complications occurred in 29.6% (n = 8/27) of the operative group compared with 25.0% (n = 4/16) of the nonoperative group resulting in 7 and 1 additional procedures, respectively.

Conclusions:
Operative treatment was associated with early benefits over nonoperative management, including shorter time using assistive devices, less SAR use, and less fracture displacement at follow-up.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
A novel biodegradable polymer-coated sirolimus-eluting stent: the 1-year results of the HELIOS registry
Authors: Zheng Bo , Liu Yi , Zhang Ruining , Yang Wangwei , Su Fangju , Wang Rutao , Chen Dapeng , Shen Guidong , Qiu Yumin , Wang Lianmin , Chen Chang , Wu Zhongwei , Li Fei , Li Jiayi , Li Chengxiang , Gao Chao , Tao Ling 
Published: June 2023

Abstract

Background:
The HELIOS stent is a sirolimus-eluting stent with a biodegradable polymer and titanium oxide film as the tie-layer. The study aimed to evaluate the safety and efficacy of HELIOS stent in a real-world setting.

Methods:
The HELIOS registry is a prospective, multicenter, cohort study conducted at 38 centers across China between November 2018 and December 2019. A total of 3060 consecutive patients were enrolled after application of minimal inclusion and exclusion criteria. The primary endpoint was target lesion failure (TLF), defined as a composite of cardiac death, non-fatal target vessel myocardial infarction (MI), and clinically indicated target lesion revascularization (TLR) at 1-year follow-up. Kaplan–Meier methods were used to estimate the cumulative incidence of clinical events and construct survival curves.

Results:
A total of 2998 (98.0%) patients completed the 1-year follow-up. The 1-year incidence of TLF was 3.10% (94/2998, 95% closed interval: 2.54%–3.78%). The rates of cardiac death, non-fatal target vessel MI and clinically indicated TLR were 2.33% (70/2998), 0.20% (6/2998), and 0.70% (21/2998), respectively. The rate of stent thrombosis was 0.33% (10/2998). Age ≥60 years, diabetes mellitus, family history of coronary artery disease, acute myocardial infarction at admission, and device success were independent predictors of TLF at 1 year.

Conclusion:
The 1-year incidence rates of TLF and stent thrombosis were 3.10% and 0.33%, respectively, in patients treated with HELIOS stents. Our results provide clinical evidence of the HELIOS stent for the evaluation of Interventional Cardiologists and Policymakers.

Clinical trial registration:
ClinicalTrials.gov, NCT03916432