bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative proteomics reveals manganese alleviates heat stress of broiler myocardial cells via regulating nucleic acid metabolism
Authors: Qin Shizhen , Wang Rui , Li Jinlu , Tang Defu , Shi Zhaoguo 
Published: April 2023

Abstract
Heat stress threatens severely cardiac function by caused myocardial injury in poultry. Our prebious study have showed that Manganese (Mn) has a beneficial effect on heat-stress resistance of broiler. Therefore, we tried to confirm the alleviation mechanism through proteomic analysis after heat stress exposure to primary broiler myocardial cells pretreated with Mn. The experiment was divided into four groups: CON group (37°C, cells without any treatment), HS group (43°C, cells treatment with heat stress for 4 h), HS + MnCl2 group (cells treated with 20 µM MnCl2 before heat stress) and HS + Mn-AA group (cells treated with 20 µM Mn compound amino acid complex before heat stress). Proteome analysis using DIA identified 300 differentially expressed proteins (DEPs) between CON group and HS group, 93 and 121 DEPs were identified in inorganic manganese treatment group and organic manganese treatment group respectively, in addition, there were 53 DEPs identified between inorganic and organic manganese group. Gene Ontology (GO) analysis showed that DEPs were mainly involved in binding, catalytic activity, response to stimulus and metabolic process. DEPs of manganese pertreatment involved in a variety of biological regulatory pathways, and significantly influenced protein processing and repair in endoplasmic reticulum, apoptosis and DNA replication and repair. These all seems to imply that manganese may help to resist cell damage induced by heat stress by regulating key node proteins. These findings contribute to a better understanding of the effects of manganese on overall protein changes during heat-stress and the possible mechanisms, as well as how to better use manganese to protect heart function in high temperature.
Research on polarization beam splitter based on metamaterial subwavelength structure
Authors: Wang Zhibin , Hou Xuwei , Li Zhengyang , Zhang Jiutian 
Published: April 2023

Abstract
Functional devices based on metamaterials have received increasing attention in recent years due to their ability to make optical devices ultra-compact and densely integrated. To address the problems of polarisation-related losses and excessive size in polarisation beam splitters (PBS), and improve its efficiency, a new PBS based on metamaterial subwavelength structure is proposed in this paper. It achieves an ultra-compact coupling region of 1.9 × 8.2 µm2, which can effectively restrain TE polarization coupling and increase TM polarization coupling. The numerical analysis results show that both TE and TM polarizations have an insertion loss of < 0.5 dB and an extinction ratio of > 20 dB within a bandwidth of 65 nm, covering the entire C-band. At 1550 nm, the extinction ratio of TM polarization is as high as 41 dB. Realize a small footprint, short coupling length, and high-efficiency PBS.
Embryonal rhabdomyosarcoma of the female gynecologic tract: a retrospective clinical study of 14 cases
Authors: Shi Shuo , Wu Liangcai , Li Ting , Zhang Haiyan , Sun Hong 
Published: April 2023

Abstract
Background
The purposes of this study were to investigate the clinical features, treatments, and prognosis of embryonal rhabdomyosarcomas (ERMS) in the female genital tract with long-term follow-up.
Methods
The data of 14 patients who diagnosis of ERMS in the genitourinary system from January 2010 to October 2022 were retrospectively screened. The roles of prognostic risk factors, such as age, tumor size, tumor grade, depth of myometrial infiltration, lymphvascular space invasion and primary treatment were evaluated.
Results
We report 14 ERMS that arose in patients aged 10 to 44 (median = 19) year. The median longest tumor diameter was 5.5 cm (range, 1.0–15.0 cm). There was no myometrial infiltration in 4 patients, superficial myometrial infiltration in 3 patients, deep myometrial infiltration in 5 patients. Lymphvascular space invasion (LVSI) was present in 2 patients, and absent in 10 patients. All of the patients performed surgery and chemotherapy, and one patient also received radiotherapy. Follow-up evaluation was lost in two patients after three or six months of combination therapy. The 2-year PFS was 83.3% and the 5-year DSS was 91.7% with a median follow-up time of 57 months (range, 10–132). Patients with LVSI (+) had a significantly increased time to progression compared with patients with LVSI (-) (PFS: p = 0.004; DSS: p = 0.046). There was a trend toward improved PFS and DSS with early-stage disease (IRSG group I/FIGO stage I (uterine sarcoma or adenosarcoma)/T1) compared to advanced-stage disease.
Conclusions
ERMS in the female gynecologic tract with early stage has a good prognosis, a conservative surgical approach combined with chemotherapy can lead to good outcomes, preserving-fertility may be possible for younger women of these patients.
Activity Concentration of Natural Radionuclides in Agricultural Soil, Fertilizer, their Transfer to Some Commonly Used Cereal Types, and Associated Health Hazards, Holeta, Ethiopia
Authors: Geremew Hailu 
Published: April 2023

Abstract
Purpose: In the current study, the concentrations of natural radionuclides in samples of agricultural soil, fertilizer and cereal types commonly used in Ethiopia were estimated. Besides, the transfer of natural radionuclides (U-238, Th-232, and K-40) from agricultural soil to identified cereal types were computed.
Materials and Methods: Gamma-ray spectrometry coupled to HPGe detector was used for the estimation of activity concentrations in soil, fertilizer and identified cereal types. Normalized relations of measured activity values with constant paremeters, given by UNSCEAR and WHO were used to investigate the related radiological parameters and radiation indices.
Results and Discussion: The average activity concentrations in samples of agricultural soil are 46.44±6.68 Bq.kg-1, 94.66±13.98 Bq.kg-1, and 368.88±51.76 Bq.kg-1 and in fertilizer samples 38.5±4.15 Bq.kg-1, 87.6±9.36 Bq.kg-1, and 334.0±35.58 Bq.kg-1 for U-238, Th-232, and K-40 respectively. In the same way, the activity concentrations of these radionuclides was measured in identified cereal types. The related radiological parameters and radiation indices in the samples of soil and fertilizer were figured and compared with the prescribed limits set by the concerned committees (UNSCEAR, WHO).
Conclusions: According to this study, U-238 and Th-232 activity concentrations in samples of soil and fertilizer are above the prescribed limits, where activities in the fertilizer are additive to the soil and in K-40 is within the safety limit. The gamma radiation exposure from the soil samples and annual effective dose via ingestion of cereals can create a risk to the public, where other investigated indices are within the safety limit prescribed by UNSEAR and WHO reports.
Unique Division Method for calculating cube root of a real number
Authors: Khanna Anupam 
Published: April 2023

Abstract
In this work, a new approach to find the cube root of real numbers is discussed. This technique is based on the classic long division method as we usually use to find the square root of real numbers. Author applied this method to ‘perfect cubes as well as non-perfect cubes real numbers (even to decimal numbers)’ and got the accuracy in the answers. This approach is unique due to its working procedure which is explained in this paper. Method is discussed step-by-step for few examples with the help of figures. No comparable work is available in the existing literature.
The Role of Clonazepam on the Control and Management of Tinnitus: A Cross-over randomized study, Damascus, Syria.
Authors: Roumieh Mirar W. , Tarrab Fatema , Dandashli Mohammad Nabil , Ataya Sham 
Published: April 2023

Abstract
Background and objectives:
Tinnitus is considered one of the most prevalent complaints among patients viewed at the E.N.T and neurological clinics. It’s defined as the perception of phantom sound, originated in the head. It’s estimated that 20% of population suffer tinnitus, 1% of which have severe symptoms affecting their quality of life, and may lead to suicide. In spite of that there is no “golden stander” test for tinnitus nor an agreed upon treatment or cure. Leaving practitioner trying with different protocols and medications for each patient.
The paper search in the use of clonazepam as an effective treatment for tinnitus or at least as a tamer for the affects it has on patient’s quality of life.
Methods:
This is a cross-over study, conducted on 80 patients who completed the inclusion criterion and signed the informed consent paper. They were randomly divided into 2 groups. The 1st group had clonazepam for 1 month as the 1st stage then they were followed using the attached survey for 3 months, for the 2nd stage they had gingko biloba “herbal medication usually used on tinnitus cases” for 1 month then were followed for 2 weeks with the same survey. The 2nd group were reversed for the medications “ginkgo biloba for the 1st stage- clonazepam for the 2nd”. This study was designed for each patient to serve as their own case-control.
Results:
A significant improvement was found during the use of clonazepam “p value < 0.05” compared to their basic status on both scales THI+VAS.
No improvement was seen during the use of gingko biloba. “p value >0.05”
Conclusion:
Clonazepam can be considered one of the effective medication for the treatment of subjective tinnitus, no matter how severe or chronic was it. It’s also advised to start to rely less on gingko biloba for the treatment of tinnitus.
C15-Imines of Natural Matrine Alkaloid as Anti-HIV-1 Agents
Authors: Lv Min , Huang Ning , Jun-Jie Li , Yang Liu-Meng , Zhang Shaoyong , Ma Qianjun , Zheng Yong-Tang , Xu Hui 
Published: April 2023

Background:
Human immunodeficiency virus (HIV) infection and acquired immunodeficiency
syndrome (AIDS) have resulted in a global health threat. Meanwhile, due to the emergence of drugresistant
HIV-1 strains, the discovery of potent compounds for antiretroviral therapy success is highly
desirable.

Objective:
This study aimed to develop anti-HIV-1 candidates which can be effectively applied for the
treatment of HIV infection.

Methods:
Based upon our previous results, a series of E isomers of C15-imines of matrine (3a-l) were
semi-synthesized from a natural quinolizidine alkaloid matrine. Their anti-HIV-1 activities were evaluated
against HIV-1ⅢB replication in acutely infected C8166 cells in vitro.

Results:
Derivatives 3c, 3h and 3j showed good anti-HIV-1 activities with EC50 and therapeutic index
(TI) values of 0.0089/0.012/0.0091 mM, and 23.71/32.49/27.43, respectively.

Conclusion:
The substituents and their corresponding positions on the phenyl ring of C15-imine derivatives
of matrine were vital for anti-HIV-1 activities. Compounds 3c, 3h and 3j can be used as leads for
further structural modification as HIV-1 inhibitors.
Is the Patient Actually Failing on Enzalutamide? A Case Report and Issues
to Consider in Enzalutamide-Resistant Oligoprogressive Metastatic
Castrate-Resistant Prostate Cancer
Authors: Papageorgiou Georgios Ioannis , Skouteris Nikolaos , Kosma Aikaterini , Markouizou Athina , Charalampakis Nikolaos 
Published: April 2023

Background:
Background: Metastatic castrate-resistant prostate cancer (mCRPC) is a challenging
disease, especially in heavily pretreated patients. Androgen pathway inhibitors have contributed to
a notable improvement in the overall survival and quality of life in patients with mCRPC during the
last decade. Still, a considerable percentage of patients are unable to draw benefits from this drug
category and are deprived of a treatment that offers limited toxicity and preserves a good quality of
life. The mechanisms leading to this pre-existing or acquired resistance, as well as the possible
strategies to overcome this resistance have been put at the center of scientists’ attention.

Case Presentation:
With the present report we present the case of a 70-year-old patient with
mCRPC, who was apparently an enzalutamide non-responder, but a multimodal approach with
enzalutamide continuation and irradiation to his symptomatic oligoprogressive disease converted
him to a responder with clinical, biochemical and imaging response; furthermore, we discuss the
existing data providing evidence for the use of metastasis-directed therapy in combination with
androgen pathway inhibitors in order to overcome drug resistance in patients with oligoprogressive
disease.

Conclusion:
A considerable proportion of patients with oligometastatic or oligoprogressive
prostate cancer who seem not to respond to androgen pathway inhibitors, such as enzalutamide, due
to preexisting or acquired resistance, could benefit from MDT with a multimodal treatment
approach. This strategy allows androgen pathway inhibitor continuation beyond biochemical
progression and delays the switch to next-line systemic treatment.
Mechanical Characteristics and Vibration Control of Railway Signal Relay
Authors: Peng Zhiping , Zhou Shan 
Published: April 2023

Introduction:
In order to solve the problems of time-consuming and poor effects of
traditional mechanical vibration control methods for the relay, the mechanical characteristics and
vibration control of railway signal relays are studied in this paper. Based on the analysis of the
mechanical characteristics of railway signal relays, the mechanical characteristic parameters of the
relay, such as contact force, initial pressure, contact clearance, and overtravel are explored. On
this basis, mechanical vibration control is completed based on particle swarm optimization.

Methods:
First, sensors are used to collect the data on the railway signal relay, and the mechanical
vibration control model of the railway signal relay is built. Then, the structure of the PID vibration
controller and LQR vibration controller in the model is analyzed. Finally, the controller parameters
are adjusted through particle swarm optimization to improve the mechanical vibration control
effect of the relay.

Results:
The simulation results show that the average signal-to-noise ratio of the method is 67dB,
the collected data has low noise, and the control time is short, which is 1.4 s.

Conclusion:
The displacement of the railway signal relay controlled by the method is always less
than 0.15 mm, and the control effect is good, which can be widely used in practice.
Exploring the Role of Mentha in Gut Microbiota: A Modern Perspective
of an Ancient Herb
Authors: Arora Swasti , Sharma Alok 
Published: April 2023

Abstract:
Gut microbiota includes the microbes present in the gut; these microbes are an essential
component in maintaining a healthy gut. Gut microbiota has a wide range of functions, including
effects on colonization, pathogen resistance, intestinal epithelial maintenance, metabolizing
food and pharmaceutical chemicals, and influencing immunological functions. Every disease
associated with the gut starts due to a disbalance in the composition of the gut microorganisms
and can be managed by balancing the composition of gut bacteria using various herbal remedies.
Mentha herbs are a variety of perennial herbs that are grown commercially in various parts of the
world. Mentha is a potent herb that shows anticholinergic action and can block PGE2 and GM1
receptors and interact with cholera toxins; it is used traditionally in different systems of medicines
to treat various gastrointestinal diseases associated with the gut. Mentha herbs have potent
bactericidal, viricidal, and fungicidal properties. Mentha has been used to cure stomach and digestion
issues as well as to treat a variety of disorders. This review article summarizes diseases
associated with the gut, the composition, and function of gut microbiota, and mentha's effectiveness
along with its extraction methods and traditional uses. Research findings revealed that mentha
could be an essential source against a wide range of diseases, especially gastrointestinal disorders.
From its ayurvedic claims to its present use, various confirmed its clinically effective for
human health. The present work also describes the mechanism of action along with the bioactives
present in this well-known herb from Ayurveda.
Sensa Mobile App for Managing Stress, Anxiety, and Depression Symptoms: Pilot Cohort Study
Authors: Valinskas Sarunas , Nakrys Marius , Aleknavicius Kasparas , Jonusas Justinas 
Published: April 2023

Background
An increase in depression, anxiety, and stress symptoms worldwide, attributed to the COVID-19 pandemic, has been reported. If not treated, it may negatively affect a person's everyday life by altering physical and social well-being and productivity and increasing expenditure on health care. Cognitive behavioral therapy (CBT)–based interventions are gaining popularity as a means to reduce stress and alleviate anxiety and depression symptoms. Moreover, CBT delivered through a mobile app has the same elements as traditional CBT training (eg, guided discovery). However, unlike conventional training, users of mobile apps are allowed to tailor their own experience at their own speed and schedule.

Objective
This study aims to analyze Sensa users’ retrospective data and explore the dose-duration effect to find the optimal usage time when the user showed results.

Methods
The study cohort comprised 381 consecutive community-based nonclinical users who started using Sensa between October 2021 and March 2022. All users included in the study took the Depression Anxiety Stress Scale-21 (DASS-21) assessment at least 2 times. Other parameters from the database containing all self-reported data were gender, number of active days, total time of use, and age. The primary outcome of the study was a change in the DASS-21 score. Statistical analyses were performed using GraphPad Prism (version 9, GraphPad Software). In addition, a logistic regression model was created to predict how the obtained independent parameters influenced the DASS-21 score.

Results
The main finding of our study was that the majority of participants who started using Sensa were experiencing depression, anxiety, and stress symptoms (92.13%, 80.05%, and 87.93%, respectively). There was a statistically significant decrease of the DASS-21 subdomain scores after the use of the application (anxiety: mean 7.25, SD 4.03 vs mean 6.12, SD 4.00; P=.001; depression: mean 11.05, SD 4.26 vs mean 9.01, SD 4.77; P=.001; stress: mean 11.42, SD 3.44 vs mean 9.96, SD 3.65; P<.001). Finally, the logistic regression model showed that users who were using the app for more than 24 days and had at least 12 active days during that time had 3.463 (95% CI 1.142-11.93) and 2.644 (95% CI 1.024-7.127) times higher chances to reduce their DASS-21 subdomain scores of depression and anxiety, respectively.

Conclusions
Using the Sensa mobile app was related to decreased depression, anxiety, and stress symptoms.
Evaluation of the Knowledge, Attitudes and Practices of the Staff of private Pharmacies in the city of Niamey and their clients on the management of Malaria in 2021
Authors: Ousmane Abdoulaye , Maiga Alhousseini Daouda , Hassoumi Aminatou Adamou , Saïdou Maman Sani Falissou , Yacouba Nazifa Ibrahim , Assoumane Samira Abdou , Souley Daouda Abdoul-Kader , Sherif Mahamat Hassan , Adehossi Eric , Djimdé Abdoulaye 
Published: April 2023

Objective: Malaria is a major public health problem in Niger. It accounts for 28% of all illnesses in the country and 50% of all death records. The objective of our study was to analyze the role played by private pharmacies in the management of uncomplicated malaria.
Material and methods: This are a descriptive analytical cross-sectional study, conducted in the form of a survey during the period from May 17 to September 15, 2021 in private pharmacies in Niamey. The study population was composed of incumbent pharmacists, assistant pharmacists, sales agents and customers of private pharmacies.
Results: A total of 10 pharmacists, 49 sales assistants and 1000 customers were interviewed. More than 62% of patients did not see a prescriber before coming to the pharmacy. Free access to anti-malarial and knowledge of the disease were the main reasons with 52.09% and 34.56% respectively. Of the sales agents, 76% had attended a training institute. Only 10% of pharmacies have a rapid diagnostic test for malaria and 7 pharmacists or 10% are aware of the existence of national control program.
Summary ad conclusion: The pharmacy team had good knowledge of the causative agent of the disease, the signs suggestive of simple malaria. However, the national guidelines for the management of malaria were unknown to pharmacists in private pharmacies.
Cosmetic Surveillance: An update and comprehensive Review
Authors: Dhiman Kritika , Kumar Rajiv 
Published: April 2023

Surveillance has recently been expanded to include the safety of herbal and cosmetic products. A new phrase has emerged characterizing industry monitoring known as “Kosmetonadzor” to ensure the safety of cosmetic products. Wigan (1997) was the first in the literature to use the term to refer to the safety management of cosmetic products. It is now recognized as a public health concept worldwide.
As there is no systematic reporting system, side effects or side effects of cosmetics are relatively insignificant or overlooked. There is a follow-up management system for preparation. In India, market surveillance is usually focused on drug side effects. As a result, more emphasis has been placed on medical devices, blood products, biologics, natural products, and special diets, and less on related side effects. To sum up, Cosmetology refers to the monitoring of cosmetic products that have recently entered the market.
Conclusions
Cosmetic surveillance is a new approach to regulating the safety of cosmetic products. It is an important component of public health initiatives. As post-sale surveillance of cosmetics becomes more and more common worldwide, malfunctions in these items can be detected and corrected, so safety can be achieved. Physicians Family doctors and general practitioners play an important role in detecting ADRs caused by cosmetic items and, as a result, urge patients to report ADRs. Raising awareness of this new notion will be an important contribution to global public health.
In general, the Cosmetovigilance system can avoid both significant and minor adverse effects. Because the notification procedure is critical to the system, healthcare workers must be taught and supported as part of the Cosmetovigilance feedback system. Some regulation modifications are required to keep up with Turkey's developing cosmetics business.
In general, cosmetic monitoring systems can prevent both serious and minor side effects. As the reporting process is a key element of the system, medical professionals must be educated and supported in terms of cosmetic oversight within the feedback system. Some regulatory updates are needed to keep pace with the changing Turkish cosmetics market.
El ejercicio de la consultoria y la gestión del cambio
Authors: Cornejo Hernán 
Published: April 2023

El trabajo se propone como objetivo generar una serie de consideraciones orientado-ras estructurales de las prácticas de Consultoría y Capacitación realizadas en pequeñas y medianas empresas de la región pampeana de la República Argentina, encuadrada en los programas que desarrolla la Secretaría de Pequeñas y Medianas empresas de la nación.
La metodología de trabajo consiste en la administración de un Cuestionario sistema-tizado el WES (Work Environment Scale) y en la sistematización de la información rele-vada en entrevistas en profundidad con titulares, ejecutivos y colaboradores de las empresas.
Los resultados más importantes se relacionan con el ejercicio de consultoría como actividad interpretativa dinamizadora de cambios, poniendo en tensión las resistencias adaptativas de las empresas, a partir de consensos internos.