bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges and opportunities offered by geostationary space observations for air quality research and emission monitoring
Authors: He Tai-Long , Oomen Glenn-Michael , Tang Wenfu , Bouarar Idir , Chance Kelly , Clerbaux Cathy , Edwards David P. , Eskes Henk , Gaubert Benjamin , Granier Claire , Guevara Marc , Jacob Daniel J. , Kaiser Jennifer , Kim Jhoon , Kondragunta Shobha , Liu Xiong , Marais Eloise A. , Miyazaki Kazuyuki , Park Rokjin , Peuch Vincent-Henri , Pfister Gabriele , Richter Andreas , Stavrakou Trissevgeni , Suleiman Raid M. , Turner Alexander J. , Veihelmann Ben , Zeng Zhao-Cheng , Brasseur Guy P. 
Published: January 2025

Abstract
Space-borne remote sensing of atmospheric chemical constituents is crucial for monitoring and better understanding global and regional air quality. Since the 1990s, the continuous development of instruments onboard low-Earth orbit (LEO) satellites has led to major advances in air quality research by providing daily global measurements of atmospheric chemical species. The next generation of atmospheric composition satellites measures from the geostationary Earth orbit (GEO) with hourly temporal resolution, allowing the observation of diurnal variations of air pollutants. The first two instruments of the GEO constellation coordinated by the Committee on Earth Observation Satellites (CEOS), the Geostationary Environment Monitoring Spectrometer (GEMS) for Asia and the Tropospheric Emissions: Monitoring of Pollution (TEMPO) for North America, were successfully launched in 2020 and 2023, respectively. The European component, Sentinel-4, is planned for launch in 2025. This work provides an overview of satellite missions for atmospheric composition monitoring and the state of the science in air quality research. We cover recent advances in retrieval algorithms, the modeling of emissions and atmospheric chemistry, data assimilation, and the application of machine learning based on satellite data. We discuss the challenges and opportunities in air quality research in the era of GEO satellites, and provide recommendations on research priorities for the near future.
Disease features at diagnosis and changes in disease course severity among commercially insured patients with childhood-onset compared with adult-onset systemic lupus erythematosus
Authors: Stokes Michael E , Phillips-Beyer Andrea , Li Qian 
Published: January 2025

Introduction Systemic lupus erythematosus (SLE) causes widespread inflammation and damage in affected organs. Severity is determined by the type of organ systems affected and the extent of involvement. SLE occurs in childhood or adulthood and disease severity varies according to age of onset. We compared disease features and changes in disease severity over time between childhood-onset (cSLE) and adult-onset SLE (aSLE). Methods Patients 0–64 years old, newly diagnosed with SLE during 2014-2020 were identified using the MarketScan® database. A validated algorithm was used to assess disease severity. Improving severity versus baseline was defined as a transition from a higher (severe) to a lower (mild/moderate) disease state during each evaluation period. Group comparisons were made using the Pearson chi-square test for categorical and t test for continuous measures. Results A total of 10,912 patients were included. Most (89.9%) were female with a mean age of 14.2 versus 44.6 years for cSLE and aSLE groups, respectively. Patients with cSLE were more likely to have severe disease at diagnosis (38.3% vs 10.7%; p < .0001) versus aSLE. The largest reduction in SLE severity occurred during 6 to <12 months post-index with cSLE experiencing the greatest improvement (36.7% vs 19.9%; p < .0001) compared with aSLE. However, despite improvements observed over time in cSLE, this group was still more likely to have severe disease at 0 to <6 months (26.4% vs 10.5%) and 6 to <12 months (14.4% vs 8.6%) post-index compared with aSLE patients ( p < .01, all). For aSLE, the proportions of patients experiencing either an improvement or deterioration in symptoms was similar during 0 to <6 months and 6 to <12 months. However, during 12 to <24 months, nearly twice as many patients in this group experienced a deterioration in symptoms (30.1%) compared to improvement (15.6%). Conclusions Children with SLE present with greater symptom severity compared with adults. Although children were more likely to experience improvements following treatment, they had more active disease over time than aSLE patients. Disease severity remained stable for aSLE patients until the second year of follow-up, when more patients experienced a deterioration rather than improvement in symptoms.
High-fidelity simulation training for improving nursing professional values acquisition
Authors: Arrogante Oscar , Ortuño-Soriano Ismael , Fernandes-Ribeiro Ana Sofia , Raurell-Torredà Marta , Jiménez-Rodríguez Diana , Zaragoza-García Ignacio 
Published: January 2025

Background Nursing professional values form the basis of nursing interventions and serve as a guide for professional practice, reflecting in all interactions with patients and other healthcare professionals. As nursing professional values constitute powerful influencers in nursing practice, a strong commitment to these values is essential for nursing students to provide high-quality care. Aim To evaluate the impact of high-fidelity simulation training on first-year nursing students’ nursing professional values acquisition. Research design Quasi-experimental study using a longitudinal design with a single group pre- and post-intervention evaluation. Participants and research context 202 first-year nursing students at the Complutense University of Madrid (Spain) participated in the study between September 2023 and May 2024. Their nursing professional values were compared at baseline and after the simulation experience using the “Nurses Professional Values Scale-Revised” (NVPS-R). The acquisition of these values was also evaluated using a verification list during simulation sessions. Five simulated scenarios recreated ethics dilemmas, where students should manage conflictive situations with a standardized patient. Ethical considerations The study was approved by the Research Ethics Committee from the Complutense University of Madrid (reference code: CE_20231116_18_SAL). Results Most of the students (84.87%) acquired the nursing professional values needed to manage adequately simulated ethical dilemmas. Nursing students significantly improved their nursing professional values after the simulation sessions. The effect size was medium for the “professional expertise” and “professional mastery” dimensions, and the total score of NVPS-R, whereas the obtained effect size was small for the “ethics” dimension. Conclusion High-fidelity simulation training using standardized patients allows first-year nursing students to acquire and improve nursing professional values. The inclusion of simulation training programs in nursing study plans to foster nursing professional values is needed to train undergraduate nursing students, providing them with the necessary ethical concepts and principles for their future clinical practice and ensuring high-quality care.
Evaluation of the predictive value of CSF-restricted oligoclonal bands on residual disability and risk of relapse in adult patients with MOGAD: MOGADOC study
Authors: Ramdani Ryan , Pique Julie , Deschamps Romain , Ciron Jonathan , Maillart Elisabeth , Audoin Bertrand , Cohen Mikael , Zephir Hélène , Laplaud David , Ayrignac Xavier , Collongues Nicolas , Ruet Aurélie , Thouvenot Eric , Bourre Bertrand , Papeix Caroline , Benyahya Lakhdar , Marignier Romain ,   for the NOMADMUS Study Group
Published: January 2025

Background: The clinical course of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is variable. However, robust markers of poor outcome and/or relapse risk are still missing. Objective: To evaluate the frequency of cerebrospinal fluid-restricted oligoclonal bands (CSF-OCB) in a national cohort of adult MOGAD patients and to assess their prognostic value for the risk of relapse and severity. Methods: We included MOGAD adult patients fulfilling the MOGAD 2023 criteria who underwent CSF analysis at maximum 3 months from onset. Results: Data from 190 patients were collected. We found the presence of CSF-OCB in 32 patients (16.8%). Positive and negative CSF-OCB patients were similar for median age at onset, sex, clinical presentation, severity at onset, and residual disability. Relapses were more frequent in the CSF-OCB+ group ( p = 0.049), particularly within the first year of follow-up ( p = 0.007). Although CSF-OCB+ was more frequently associated with imaging features suggestive of multiple sclerosis (MS) ( p = 0.014), 78% of these patients fulfilled the 2023 supportive features and 65% experienced lesion vanishing at follow-up magnetic resonance imaging (MRI). Conclusion: We found a higher risk of relapse in MOGAD with CSF-OCB particularly during the first year. Close attention is recommended regarding the risk of misdiagnosis with MS.
Using photo-elicitation to explore young people’s short-term experience of and adherence to orthodontic retainers
Authors: Smorthit Kelly , Littlewood Simon , Maroke Tara , Pini Simon , Barber Sophy 
Published: January 2025

Objective: To investigate young people’s experience of retainer wear in the immediate term and at 6 months after appliance removal, and to explore the factors affecting retainer wear adherence. Design: Qualitative study. Setting: Orthodontic departments at two teaching hospitals in Yorkshire, UK. Participants: A total of 12 participants aged 13–18 years were recruited using a purposive sampling approach. Methods: Data collection occurred through one-to-one, virtual, photo-elicitation interviews at two time points (immediate and 6 months) with data analysed using interpretative phenomenological analysis (IPA). Results: Three overarching themes were developed to describe young people’s experience of orthodontic retention: immediate experience and expectation of retainers; the process of adaptation; and motivating factors. Barriers to adherence were mostly ascribed to daytime wear, despite normalisation of retainers in young people’s lives. Interventions to help individuals overcome the initial adaptation phase and self-manage their foreseen problems of forgetfulness include routines and reminders, which seem to be less important at 6 months. At both time points, internal and external motivation significantly contribute to retainer adherence, with compensatory changes in behaviour being more important at 6 months. Conclusions: Understanding early experiences of retainer wear can help clinicians to provide timely and well-targeted interventions and information. Co-constructing unique adherence strategies may help to overcome the initial adaptation phase, with particular emphasis on understanding the individual.
Balance Changes in Adult Cancer Survivors Participating in a 16-Week Therapeutic Yoga Program
Authors: Miller Mark J. , Hughes Daniel C. , Darby Nydia T. , Calderon Tim , Patel Darpan I. , Serra Monica C. , Ramirez Amelie G. , Ortiz Alexis , Almeida Gustavo J. 
Published: January 2025

Introduction: Balance problems arising from cancer and its treatments can significantly impact daily functionality and quality of life. Improving balance as part of a cancer treatment plan could result in better patient outcomes. Thus, the aim of this study was to determine whether an integrative therapeutic yoga intervention can improve balance in a heterogenous population of cancer survivors (CS). Methods: This is a secondary analysis of data from a 16-week feasibility study where therapeutic yoga was supplemented with psychosocial support to maximize health-related quality of life in adult CS of any stage and site. In this study, we investigated balance, as it has been shown to be an important outcome in CS due to its role in physical function and quality of life. The intervention included therapeutic yoga three times per week for 16 weeks and daily psychosocial support provided via text message. Participants’ balance was assessed while standing on a pressure mat with feet together, eyes opened and closed, for 30 seconds in each condition. Data on the “sway path distance” (displacement of the center of gravity) in the two conditions were obtained. Changes in balance after the intervention (from baseline to follow-up) were analyzed using paired-sample t-tests. Changes in balance were also assessed using responder analysis. We described the proportion of participants that improved their balance or not based on 10% difference from baseline scores. Results: Of the 29 participants included, 22 (76%) completed post-assessments. Changes in both balance assessment conditions were not statistically significant (eyes opened: 80.06 ± 374.99, p = .702; eyes closed: −1.82 ± 24.01, p = .068). Responder analysis showed that 8 participants improved their balance with eyes opened, while 8 worsened, and 6 did not change. Analysis of balance with eyes closed showed that 5 improved, 8 worsened, and 9 did not change. Conclusion: This secondary analysis of data from a heterogenous cohort of adult CS did not support our hypothesis at the group level. However, at the individual level, responder analysis indicated improved balance in some survivors. Future research is needed to determine factors related to the cancer experience which might mediate balance outcomes to inform better integrative interventions.
Pediatric-onset PRKN disease: New insights into an understudied population
Authors: Gonul Oner Ozge , Biboulet Bruneau Céline , Fraix Valérie , Bourg Véronique , Defebvre Luc , Mutez Eugénie , Roze Emmanuel , Laroche Cécile , Béreau Matthieu , Nguyen-Morel Marie-Ange , Moro Elena 
Published: January 2025

Background In pediatric age, the PRKN mutation is reported as one of the most common genetic causes of Parkinson's disease. However, detailed clinical data on PRKN patients with pediatric onset are scarce. Objective To describe clinical characteristics, disease progression, and management of PRKN patients with pediatric onset. Methods PRKN patients with onset of clinical signs before the age of 18 years were included in this retrospective multicenter study. Collected data included detailed clinical characteristics, progression, and disease management. Data presentation is descriptive due to the sample size. Results Nine patients (five females) were included from five French movement disorders centers. The mean age at symptom onset was 10.78 ± 2.22 years (median, 11; range, 7–14). Dystonia was the first most common motor symptom (six patients). The mean time from symptom onset to genetic diagnosis was 13.33 ± 9.21 years (median, 11; range, 3–32). The most commonly reported non-motor symptoms were sleep disorders (seven patients), anxiety (six patients), and depression (five patients). The first treatment was L-dopa in four patients, dopamine agonist in two, carbamazepine in two, and rasagiline in one. Dyskinesia and impulse control disorders were the most common treatment-related side effects (nine and six patients, respectively). Four patients underwent deep brain stimulation surgery. The last available follow-up was at 27.22 ± 14.05 years (median, 28; range, 6–56) after the diagnosis. Conclusions This is the first study reporting detailed clinical features and long-term management of PRKN patients with pediatric onset. Prompt diagnosis and appropriate treatment strategies are important to optimize disease management.
Comparing Tibiofemoral Rotation Measurements Between Computed Tomography and Magnetic Resonance Imaging in Patients With Patellofemoral Instability
Authors: Jud Lukas , Berger Alexander , Hartmann Martin , Vlachopoulos Lazaros , Ackermann Jakob , Fucentese Sandro F. 
Published: January 2025

Background: Tibiofemoral rotation is an emerging parameter, especially in assessing patellofemoral instability. However, reference values in the literature are inconsistent regarding the used imaging modality and do not consider the effect of knee flexion during image acquisition. Purpose: To analyze the differences in tibiofemoral rotation measurements between computed tomography (CT) and magnetic resonance imaging (MRI). Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 78 knees in 72 patients were included. All patients underwent surgery for patellofemoral instability at our institution and preoperative CT and MRI were available. Tibiofemoral rotation was measured on axial CT and MRI, whereas the respective knee flexion angle (KFA) was measured on sagittal images. Tibiofemoral rotation values in which the tibia was externally rotated to the femur were handled as positive values. Differences between CT and MRI measurements were calculated and the association between KFA and tibiofemoral rotation was evaluated using Pearson correlation and the Mann-Whitney U test. Results: The mean tibiofemoral rotation was 8.7°± 5.5° in CT and 4.2°± 6.7° in MRI ( P < .001). The mean KFA was 2.4°± 3.1° in CT and 14.9°± 6.4° in MRI ( P < .001). The difference in the KFA between CT and MRI moderately correlated with the difference in tibiofemoral rotation between imaging modalities ( r = 0.529; P < .001). Conclusion: Tibiofemoral rotation measurements significantly differed between CT and MRI, with larger values observed in CT. The difference between imaging modalities correlated with the degree of knee flexion during image acquisition. This observation should be considered when assessing tibiofemoral rotation, as current reference values in the literature are inconsistent regarding the used imaging modality.
Effectiveness of workplace health promotion programs for industrial workers: a systematic review
Authors: Javanmardi Sasha , Rappelt Ludwig , Zangenberg Sascha , Heinke Lars , Baumgart Christian , Niederer Daniel , Freiwald Jürgen 
Published: January 2025

Abstract

Background
Workplace health promotion is essential for individual and organisational well-being and disease prevention, also in industrial workers. As the transfer of the evidence on the effectiveness of such programs into practice is limited due to scattered effects, the need for a consolidation of the available studies is given. The purpose of this systematic review was to synthesise the evidence on the effectiveness of workplace health promotion programs for industrial workers.

Methods
An electronic literature search was conducted in PubMed, Cochrane Library, Web of Science™, Scopus, and EBSCOHost until July 26th 2023. Studies investigated industrial workers who performed manual labour for at least 20 h per week were included. They had to receive a workplace health promotion intervention under any control condition. Outcomes were workplace health interventions’ safety and corresponding health-related outcomes. The revised Cochrane risk-of-bias assessed the risk of bias (Rob 2) tool for randomised control trials (RCT) and cluster RCT. Quality assessment was performed using a modified Downs and Black Checklist.

Results
Of the 25,555 studies initially identified, 39 were included. Generally, the mean quality of the studies was moderate, with most studies judged with a high overall risk of bias. Twenty-seven studies employed a behavioural approach, while one study adopted an organisational one. Ten studies utilised a multicomponent approach, and one intervention improved safety outcomes. The analysis of the results indicated an overall positive but heterogeneous effect across the different approaches.

Conclusions
The studies included in this review provide evidence that workplace health promotion can be effective. However, the overall findings are inconclusive due to the high risk of bias. Therefore, the results should be interpreted cautiously. Despite the considerable amount of research conducted in this field, additional well-designed studies are needed to fully confirm the effectiveness and determine the most promising types of interventions for improving and maintaining industrial health.
The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis
Authors: Marona Paulina , Myrczek Rafał , Piasecka Iga , Gorka Judyta , Kwapisz Oliwia , Pospiech Ewelina , Rys Janusz , Jura Jolanta , Miekus Katarzyna 
Published: January 2025

Abstract
The RNase activity of MCPIP1 is essential for regulating cellular homeostasis, proliferation, and tumorigenesis. Our study elucidates the effects of downregulation of MCPIP1 expression and an RNase-inactivating mutation (D141N) on normal epithelial kidney cells, indicating that MCPIP1 expression is a key factor that suppresses neoplastic transformation. We observed that either expression downregulation or mutation of MCPIP1 significantly increased its clonogenicity and altered the expression of cancer stem cell (CSC) markers and factors involved in epithelial-to-mesenchymal transition (EMT). In vivo studies demonstrated that MCPIP1 inactivation in normal epithelial cells leads to significant tumor formation and increased c-Myc phosphorylation, indicating enhanced cell proliferation. Proteomic analysis of mouse plasma revealed increased secretion of cancer-related proteins (CXCL13, CXCL16, and MMP2) in the MCPIP1-mutant group. Additionally, we revealed that MCPIP1 RNase activity regulates the expression of the stemness markers CD44 and CD133 and the phosphorylation of the c-Met receptor in tumor tissue samples. Mechanistically, via coimmunoprecipitation analysis, we found that the RNase activity of MCPIP1 controls CD44 expression and, consequently, that a strong interaction between CD44 and c-Met leads to c-Met activation. This regulation was confirmed in patient samples, in which increased CD44 expression correlated with ccRCC progression. These findings highlight the critical role of MCPIP1 RNase activity in modulating the c-Met/CD44 axis, thereby influencing stemness and tumorigenesis.
SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease
Authors: Bhalla Mridula , Joo Jinhyeong , Kim Daeun , Shin Jeong Im , Park Yongmin Mason , Ju Yeon Ha , Park Uiyeol , Yoo Seonguk , Hyeon Seung Jae , Lee Hyunbeom , Lee Junghee , Ryu Hoon , Lee C. Justin 
Published: January 2025

Abstract

Background
Alzheimer’s Disease (AD) is a neurodegenerative disease with drastically altered astrocytic metabolism. Astrocytic GABA and H2O2 are associated with memory impairment in AD and synthesized through the Monoamine Oxidase B (MAOB)-mediated multi-step degradation of putrescine. However, the enzymes downstream to MAOB in this pathway remain unidentified.

Methods
Using transcriptomics analysis, we identified two candidate enzymes, Aldehyde Dehydrogenase 1 family member A1 (ALDH1A1) and Sirtuin 2 (SIRT2) for the steps following MAOB in the astrocytic GABA production pathway. We used immunostaining, metabolite analysis and electrophysiology, both in vitro and in vivo, to confirm the participation of these enzymes in astrocytic GABA production. We checked for the presence of SIRT2 in human AD patients as well as the mouse model APP/PS1 and finally, we selectively ablated SIRT2 in the astrocytes of APP/PS1 mice to observe its effects on pathology.

Results
Immunostaining, metabolite analysis, and electrophysiology recapitulated the participation of ALDH1A1 and SIRT2 in GABA production. Inhibition of SIRT2 reduced the production of astrocytic GABA but not H2O2, a key molecule in neurodegeneration. Elevated expression of these enzymes was found in hippocampal astrocytes of AD patients and APP/PS1 mice. Astrocyte-specific gene-silencing of SIRT2 in APP/PS1 mice restored GABA production and partially improved memory function.

Conclusions
Our study is the first to identify the specific role of SIRT2 in reactive astrogliosis and determine the specific pathway and metabolic step catalyzed by the enzyme. We determine the partial, yet significant role of ALDH1A1 in this process, thereby highlighting 2 new players the astrocytic GABA production pathway. Our findings therefore, offer SIRT2 as a new tool to segregate GABA from H2O2 production, aiding future research in neurodegenerative diseases.

Graphical Abstract