bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ohwia caudata extract relieves the IL‐17A‐induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2/STAT3 activation
Authors: Lu Cheng‐You , Kuo Chia‐Hua , Kuo Wei‐Wen , Hsieh Dennis Jine‐Yuan , Wang Tso‐Fu , Shih Cheng‐Yen , Lin Pi‐Yu , Lin Shinn‐Zong , Ho Tsung‐Jung , Huang Chih‐Yang 
Published: May 2023

AbstractFibroblast‐like synoviocytes accumulation, proliferation and activation, and the subsequent inflammatory mediators production play a key role in the progression of rheumatoid arthritis (RA). It is well established that Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling triggers inflammation, and induces cytokine levels in RA. Ohwia caudata have long been used against many disorders. However, in RA, the effects of O. caudata have not been elucidated. In the current study, synoviocytes were used to evaluate the suppressive effects of O. caudate extract (OCE) on the pro‐inflammatory cytokines production. In vitro, the underlying mechanisms by which OCE inhibits inflammatory response through regulation of suppressors of cytokine signaling 3 (SOCS3) and JAK2/STAT3 expression in IL‐17A‐treated HIG‐82 synoviocytes were investigated. The results demonstrated that the proliferation of IL‐17A‐challenged cells were increased in comparison with non‐stimulated control cells. The synoviocyte proliferation was decreased significantly of OCE concentrations in dose dependent manner. The p‐JAK2, p‐STAT3, interleukin (IL)‐1β, and IL‐6 were reduced in IL‐17A‐challenged cells treated with OCE. Furthermore, AZD1480 (a JAK2‐specific inhibitor) or WP1066 (a STAT3‐specific inhibitor) affected the inflammatory mediators production in IL‐17A‐challenged synoviocytes, and OCE failed to mitigate the IL‐17A‐induced inflammatory mediators and SOCS3, acting as a feedback inhibitor of the JAK/STAT3 pathway, in the presence of SOCS3 siRNA, indicating that the beneficial effects of OCE on the regulation of inflammatory response homeostasis were dependent on SOCS3 and the JAK2/STAT3 signaling pathway. Our study also showed that SOCS3 was markedly activated by OCE in RA fibroblast‐like synoviocytes, thereby decreasing the JAK/STAT3 pathway, and the IL‐1β, and IL‐6 activation. Thus, O. caudate should be further investigated as a candidate anti‐inflammatory and anti‐arthritic agent.
Sensitivity of a homogeneous and isotropic second‐gradient continuum model for particle‐based materials with respect to uncertainties
Authors: La Valle Gabriele , Abali Bilen Emek , Falsone Giovanni , Soize Christian 
Published: May 2023

AbstractThis work concerns the probabilistic analysis of particle‐based materials. More precisely, this work is devoted to the stochastic modeling of the geometric and constitutive microscale parameters associated with particle‐pair interactions of an existing model for particle‐based materials. Such an issue is addressed with a probabilistic methodology that relies on the maximum entropy principle from information theory. After defining and improving the chosen second‐gradient continuum model for particle‐based materials, it is shown that for micro‐homogeneous and micro‐isotropic materials, the involved microscale parameters turn out to be statistically independent. More precisely, the particle‐pair distance between two consecutive particles is a uniformly distributed random variable and the specific micro‐scale stiffness parameters are Gamma‐distributed random variables. A homogeneous and isotropic 2D concrete plate subjected to an axial load is considered for illustration purposes. A stochastic solver based on Monte Carlo numerical simulations and mixed finite element (FE) method are chosen. The FE discretization is applied to the weak formulation of the equivalent continuum model with random mechanical properties. On the contrary, the particle‐pair distance and the micro‐scale stiffness parameters, which are the parameters of the boundary value problem formulated for the equivalent continuum model, are modeled as random variables. Finally, uncertainties propagation is discussed and statistical fluctuations of the macro mechanical response are found to be significant.
On higher-spin $$ \mathcal{N} $$ = 2 supercurrent multiplets
Authors: Kuzenko Sergei M. , Raptakis Emmanouil S. N. 
Published: May 2023

Abstract
We elaborate on the structure of higher-spin $$ \mathcal{N} $$
N
= 2 supercurrent multiplets in four dimensions. It is shown that associated with every conformal supercurrent $$ {J}_{\alpha (m)\overset{\cdot }{\alpha }(n)} $$

J

α

m

α
⋅

n

(with m, n non-negative integers) is a descendant $$ {J}_{\alpha \left(m+1\right)\overset{\cdot }{\alpha}\left(n+1\right)}^{ij} $$

J

α

m
+
1

α
⋅

n
+
1

ij

with the following properties: (a) it is a linear multiplet with respect to its SU(2) indices, that is $$ {D}_{\beta}^{\Big(i}{J}_{\alpha \left(m+1\right)\overset{\cdot }{\alpha}\left(n+1\right)}^{jk\Big)}=0 $$

D
β

(
i

J

α

m
+
1

α
⋅

n
+
1

jk
)

=
0
and $$ {\overline{D}}_{\dot{\beta}}^{\Big(i}{J}_{\alpha \left(m+1\right)\overset{\cdot }{\alpha}\left(n+1\right)}^{jk\Big)}=0 $$

D
¯

β
̇

(
i

J

α

m
+
1

α
⋅

n
+
1

jk
)

=
0
; and (b) it is conserved, $$ {\partial}^{\beta \overset{\cdot }{\beta }}{J}_{\beta \alpha (m)\overset{\cdot }{\beta}\overset{\cdot }{\alpha }(n)}^{ij}=0 $$

∂

β

β
⋅

J

βα

m

β
⋅

α
⋅

n

ij

=
0
. Realisations of the conformal supercurrents $$ {J}_{\alpha (s)\overset{\cdot }{\alpha }(s)} $$

J

α

s

α
⋅

s

, with s = 0, 1, …, are naturally provided by a massless hypermultiplet and a vector multiplet. It turns out that such supercurrents and their linear descendants $$ {J}_{\alpha \left(s+1\right)\overset{\cdot }{\alpha}\left(s+1\right)}^{ij} $$

J

α

s
+
1

α
⋅

s
+
1

ij

do not occur in the harmonic-superspace framework recently described by Buchbinder, Ivanov and Zaigraev. Making use of a massive hypermultiplet, we derive non-conformal higher-spin $$ \mathcal{N} $$
N
= 2 supercurrent multiplets. Additionally, we derive the higher symmetries of the kinetic operators for both a massive and massless hypermultiplet. Building on this analysis, we sketch the construction of higher-derivative gauge transformations for the off-shell arctic multiplet Υ(1), which are expected to be vital in the framework of consistent interactions between Υ(1) and superconformal higher-spin gauge multiplets.
Massive theta lifts
Authors: Berg Marcus , Persson Daniel 
Published: May 2023

Abstract
We use Poincaré series for massive Maass-Jacobi forms to define a “massive theta lift”, and apply it to the examples of the constant function and the modular invariant j-function, with the Siegel-Narain theta function as integration kernel. These theta integrals are deformations of known one-loop string threshold corrections. Our massive theta lifts fall off exponentially, so some Rankin-Selberg integrals are finite without Zagier renormalization.
Dilaton at the LHC: complementary probe of composite Higgs
Authors: Bruggisser Sebastian , von Harling Benedict , Matsedonskyi Oleksii , Servant Géraldine 
Published: May 2023

Abstract
The dilaton is predicted in various extensions of the standard model containing sectors with an approximate spontaneously-broken conformal invariance. As a Goldstone boson of a spontaneously broken symmetry, the dilaton can naturally be one of the lightest new physics particles, and therefore may be the first new physics imprint observed in collider experiments. In particular, it can arise in composite Higgs models which are often assumed to have approximate conformal invariance in the UV. The dilaton is then a composite state, generated by the same sector that produces the Higgs. We continue the exploration of composite dilaton signatures at the LHC, using the latest experimental data and analysing the future detection prospects. We elaborate on the connection of the dilaton properties with the properties of the Higgs potential, clarifying in particular the relation between the scale relevant for electroweak fine tuning and the scale controlling the dilaton couplings. This relation is then used to derive the experimental sensitivity to the dilaton in natural composite Higgs scenarios, which reaches ~ 3 TeV in dilaton mass for generic parameter choices. At the same time, we show that dilaton searches are a complementary direction to probe Higgs boson compositeness, with the sensitivity comparable or exceeding that of Higgs coupling measurements.
Hamming Sandwiches
Authors: Eberhard Sean 
Published: May 2023

AbstractWe describe primitive association schemes $${\mathfrak {X}}$$
X
of degree n such that $$\textrm{Aut}({\mathfrak {X}})$$

Aut
(
X
)

is imprimitive and $$|\textrm{Aut}({\mathfrak {X}})| \ge \exp (n^{1/8})$$

|
Aut

(
X
)

|

≥
exp

(

n

1
/
8

)

, contradicting a conjecture of Babai. This and other examples we give are the first known examples of nonschurian primitive coherent configurations (PCC) with more than a quasipolynomial number of automorphisms. Our constructions are “Hamming sandwiches”, association schemes sandwiched between the dth tensor power of the trivial scheme and the d-dimensional Hamming scheme. We study Hamming sandwiches in general, and exhaustively for $$d \le 8$$

d
≤
8

. We revise Babai’s conjecture by suggesting that any PCC with more than a quasipolynomial number of automorphisms must be an association scheme sandwiched between a tensor power of a Johnson scheme and the corresponding full Cameron scheme. If true, it follows that any nonschurian PCC has at most $$\exp O(n^{1/8} \log n)$$

exp
O
(

n

1
/
8

log
n
)

automorphisms.
Student mistakes and teacher reactions in bedside teaching
Authors: Rubisch Hannah P. K. , Blaschke Anna-Lena , Berberat Pascal O. , Fuetterer Cornelia S. , Haller Bernhard , Gartmeier Martin 
Published: May 2023

AbstractWe analyse interactions between teachers and students during video-recorded bedside teaching sessions in internal medicine, orthopaedics and neurology. Multiple raters used a high-inference categorical scheme on 36 sessions. Our research questions concern the types of student mistakes, clinical teachers’ reactions to them and if they use different strategies to address different types of mistakes. We used a Poisson model and generalized mixed models to analyse these research questions. Most frequently, students made reproduction mistakes. Relatively high rates of rejection and a similar prevalence of low and high levels of elaboration and correction time for students were observed. Reproduction mistakes were associated with the highest level of rejection and the lowest level of elaboration. High levels of elaboration were observed when students were applying skills in new situations. Students were most often allowed time to correct when mistakes in the areas of analysis or application of skills and knowledge had occurred. There is a decrease in the rate of making mistakes for neurology and orthopaedics compared to internal medicine. Reproduction mistakes influence significantly the outcome feedback compared to application mistakes. Analytic and reproduction mistakes influence elaboration significantly compared to application mistakes. We found a significant effect whether the lecturer allows time for correction of reproduction mistakes compared to application mistakes. These results contribute to the understanding of interactive, patient-centred clinical teaching as well as student mistakes and how teachers are reacting to them. Our descriptive findings provide an empirical basis for clinical teachers to react to student mistakes in didactically fruitful ways.
A comparison between TOPSIS and SAW methods
Authors: Ciardiello Francesco , Genovese Andrea 
Published: May 2023

AbstractThe Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) and Simple Additive Weighting (SAW) are among the most employed approaches for aggregating performances in Multi-Criteria Decision-Making (MCDM). TOPSIS and SAW are two MCDM methods based on the value function approach and are often used in combination with other MCDM methods in order to produce rankings of alternatives. In this paper, first, we analyse some common features of these two MCDM methods with a specific reference to the additive properties of the value function and to the sensitivity of the value function to trade-off weights. Based on such methodological insights, an experimental comparison of the results provided by these two aggregation methods across a computational test is performed. Specifically, similarities in rankings of alternatives produced by TOPSIS and SAW are evaluated under three different Minkowski distances (namely, the Euclidean, Manhattan and Tchebichev ones). Similarities are measured trough a set of statistical indices. Results show that TOPSIS, when used in combination with a Manhattan distance, produces rankings which are extremely similar to the ones resulting from SAW. Similarities are also Experimental results confirm that rankings produced by TOPSIS methods are closer to SAW ones when similar formal properties are satisfied.
Barriers and facilitators to effective cervical cancer screening in Belize: a qualitative analysis
Authors: Mittal Avni , Neibart Shane S. , Kulkarni Abha , Anderson Taylor , Hudson Shawna V. , Beer Natalia Largaespada , Einstein Mark H. , Kohler Racquel E. 
Published: May 2023

Abstract
Purpose
Belize has among the highest cervical cancer incidence and mortality rates of Latin American and Caribbean countries. This study evaluates the perspectives of key stakeholders for cervical cancer screening in Belize and identifies the barriers and facilitators for providing equitable access to prevention services.

Methods
Semi-structured interviews discussing cervical cancer screening were conducted with key stakeholders across the six districts of Belize in 2018. Interviews were transcribed, coded, and analyzed thematically; themes were organized by levels of the social-ecological model.

Results
We conducted 47 interviews with health care providers (45%), administrators (17%), government officials (25%), and other stakeholders (13%). Majority (78%) of interviews were from the public sector. Perceived barriers to cervical cancer screening were identified across multiple levels: (1) Individual Patient: potential delays in Pap smear results and fear of a cancer diagnosis; (2) Provider: competing clinician responsibilities; (3) Organizational: insufficient space and training; (4) Community: reduced accessibility in rural areas; and (5) Policy: equipment and staffing budget limitations. The main facilitators we identified included the following: (1) at the Community level: resource-sharing between public and private sectors and dedicated rural outreach personnel; (2) at the Policy level: free public screening services and the establishment of population-based screening.

Conclusion
Despite free, publicly available cervical cancer screening in Belize, complex barriers affect access and completion of management when abnormal screening tests are identified. Provider workload, education outreach, and additional funding for training and facilities are potential areas for strengthening this program and increasing detection and management for cervical cancer control.
Strong decreases in genetic diversity despite high gene flow for a solitary bee
Authors: Suni Sevan , Hernandez Melissa 
Published: May 2023

AbstractMany organisms live in landscapes that include fragments of natural habitat interspersed with agricultural or urban areas. In such areas, dispersal across human-dominated landscapes may be important for the maintenance of genetic diversity within habitat fragments. Understanding the extent to which dispersal occurs across fragmented habitat and how genetic diversity changes over time is particularly important for bee populations. Population sizes of many bee species are declining, which can have profound negative impacts on both agricultural pollination and the fitness of wild plants. We quantified dispersal across 100 km of mixed landscapes in southern Costa Rica for the solitary bee species Euglossa championi, and we quantified changes in genetic diversity over an eleven-year period. Our SNP-based analysis revealed high dispersal across the geographic area and no evidence that deforestation restricted dispersal. However, we found strong decreases in genetic diversity over time. Expected heterozygosity decreased by 28% over eleven years, regardless of the amount of forest that surrounded sites. Our results suggest that while high dispersal over deforested landscapes may render E. championi less susceptible to land use change than species that show restricted dispersal, the strong decrease in genetic diversity within sites over time suggests this species may warrant conservation monitoring.
Out-of-the-box library support for DBMS operations on GPUs
Authors: Subramanian Harish Kumar Harihara , Gurumurthy Bala , Durand Gabriel Campero , Broneske David , Saake Gunter 
Published: May 2023

AbstractGPU accelerated query execution is still ongoing research in the database community, as GPUs continue to be heterogeneous in their architectures varying their capabilities (e.g., their newest selling point: tensor cores). Hence, many researchers come up with optimal operator implementations for a specific device generation involving tedious operator tuning by hand. Alternatively, there is a growing availability of GPU libraries providing optimized operators for various applications. However, the question arises of how mature these libraries are and whether they are fit to replace handwritten operator implementations not only w.r.t. implementation effort and portability but also performance. In this paper, we investigate various general-purpose libraries that are both portable and easy to use for arbitrary GPUs to test their production readiness on the example of database operations. To this end, we develop a framework to show the support of GPU libraries for database operations that allows a user to plug-in new libraries and custom-written code. Our framework allows for easy pluggability of new libraries for query execution using a simple task model. Using this framework, we develop multiple libraries (ArrayFire, Thrust, and boost.compute) supporting many database operations. We use these libraries to experiment with different devices to see the impact of the underlying device. Based on our experiments, we see a significant diversity in terms of performance among libraries. Furthermore, one of the fundamental database primitives—hashing, and thus hash joins—is currently not supported, leaving important tuning potential unused.
The association of a combined healthy lifestyle with the risk of postmenopausal breast cancer subtypes in the Netherlands Cohort Study
Authors: van den Brandt Piet A. 
Published: May 2023

AbstractThe association between combined healthy lifestyle and postmenopausal breast cancer risk has been studied in various cohort studies, but only few evaluated the association with estrogen/progesterone (ER/PR) receptor subtypes of breast cancer, with inconsistent results. The relationship of a healthy lifestyle score (HLS) with risk of postmenopausal breast cancer (subtypes) was investigated in the Netherlands Cohort Study. In 1986, 62,573 women aged 55–69 years provided information on dietary and lifestyle habits. The HLS was derived from information on smoking, body mass index, physical activity, Mediterranean diet adherence, and alcohol intake. After 20.3 years of follow-up, multivariable case-cohort analyses were based on 2321 incident breast cancer cases, and 1665 subcohort members with complete data on lifestyles and confounders. The HLS showed a statistically significant inverse relationship with postmenopausal breast cancer risk, in a linear fashion. A one-point increment of the HLS was accompanied by a Hazard Ratio (HR) reduction of 20% for overall breast cancer. The associations between HLS and risk of ER/PR breast cancer subtypes were also significantly inverse, except for ER- breast cancer where the inverse association did not reach statistical significance. Per HLS-increment of one point, the HR reduction ranged from 14% for ER-breast cancer to 29% for ER + PR- breast cancer. These findings suggest that adhering to a combination of healthy modifiable lifestyle factors may substantially reduce the risk of overall postmenopausal breast cancer and its hormone receptor subtypes.
Semantic Information and the Complexity of Deduction
Authors: Panahy Salman 
Published: May 2023

Abstract
In the chapter “Information and Content” of their Impossible Worlds, Berto and Jago provide us with a semantic account of information in deductive reasoning such that we have an explanation for why some, but not all, logical deductions are informative. The framework Berto and Jago choose to make sense of the above-mentioned idea is a semantic interpretation of Sequent Calculus rules of inference for classical logic. I shall argue that although Berto and Jago’s idea and framework are hopeful, their definitions do not capture what is intended. This is so because the definitions are solely based on the logical complexity of an argument and they fail to capture the richness of the non-logical content of that argument. Then I will suggest some amendments to address this problem. Finally, I will extend the application of the definitions to first-order logic. It shall be observed that in some classical deductions, applying contraction may lead to hiding some epistemic impossibilities. This happens when formulae which contribute different propositions to the proof get contracted at the quantified level.
Local Ties as Self-Reported Constraints to Internal Migration in Spain
Authors: Thomassen Jonne A. K. , Palomares-Linares Isabel , Venhorst Viktor A. , Mulder Clara H. 
Published: May 2023

AbstractThe internal migration literature has identified various factors that deter migration and encourage staying, but has been less concerned with people’s own reports about what makes it difficult for them to migrate or makes them want to stay. We explore factors that make it difficult to change the place of residence—from here on denoted as constraints—reported in the Spanish survey on Attitudes and Expectations of Spatial Mobility in the Labour Force (N = 3892). These constraints were uniquely asked from all respondents through an open-ended question, regardless of their migration intentions. We find that many self-reported constraints correspond to factors that have previously been associated with decreased migration propensities. In order of frequency, respondents reported ties to family and friends, ties to their residential environment, financial limitations, and ties to work as constraints to migration. Our results further show that the likelihood of mentioning ties to family and friends as constraints decreased with age, was higher for women than for men and for people who lived close to most of their social network than for those who did not. Mentioning ties to the residential environment as constraints was positively associated with being partnered, and also with living in one’s birthplace. People who were unemployed were less likely to mention ties to work and were more likely to report financial limitations as constraints than people who had a permanent contract—whereas being self-employed was positively associated with mentioning ties to the residential environment.