bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wood and bark anatomy of the charismatic Wisteria vines (Leguminosae)
Authors: Nejapa Rosa , Pace Marcelo R. 
Published: March 2023

Summary
Wisteria is a legume genus composed of lianas with a disjunct distribution, occurring in temperate zones of eastern Asia and the eastern United States, being also introduced in numerous countries as an ornamental. The anatomy of the wood has been previously studied for W. sinensis and only some characteristics of the phloem have been reported for this species. Here we describe the overall wood and bark anatomy of four Wisteria species and identify diagnostic, informative anatomical features to sort them for identification purposes among the species of the genus. Samples were collected from natural, naturalized, and introduced populations and processed using traditional anatomical techniques, while a few samples were analyzed from photos available online. Wisteria species show conserved wood anatomy, even if species occur as far apart as Asia and North America. The presence of a cambial variant, vessel dimorphism, G-fibers, non-lignified axial, and ray parenchyma is common and is here interpreted as part of the lianescent syndrome. The subepidermal origin of the periderm is taxonomically informative within the subfamily. The few variable features that vary among species are the arrangement of narrow vessels: radial to dendritic pattern in the specie W. frutescens and arranged in clusters in the species distributed in Eastern Asia. Also, the ray cell composition: procumbent, square, and upright cells mixed through the body in the specie W. sinensis and procumbent to square cells in the body and upright in the margins in the species W. brachybotrys and W. frutescens.
Why Is the ‘Timaeus’ So Important for Middle Platonists (Again)? A New Proposal
Authors: Piazzalunga Arianna , Petrucci Federico Maria 
Published: March 2023

Abstract
This paper aims to show that the Middle Platonists’ appeal to the Timaeus was grounded in a complex and effective philosophical reasoning: the Middle Platonists conceived of Plato’s text as a web of passages which Plato himself had carefully established. Only a few of them were granted a qualified priority, namely, those offering a complete and comprehensive philosophical account of the key elements which the Platonists regarded as fundamental. This will allow us to show that the Middle Platonists’ preference for the Timaeus does not depend on the fact that it is systematic. Rather it is systematic insofar as it proves capable of giving context to passages from other dialogues and provides them with an account that is philosophically sound.
Plato’s Republic 515a5: Prisoners ‘Like Us’
Authors: Gkatzaras Thanassis 
Published: March 2023

Abstract
This paper questions the traditional interpretation of Plato’s Republic 515a5. When Socrates claims that the prisoners in the simile of the Cave are ‘like us’, he does not imply any sort of similarity or analogy between their cognitive state and ours. Rather, I argue he says that we should imagine a cave inhabited by ordinary human beings, instead of some fictitious creatures. Among other things, Plato’s intent is to highlight the weakness of our human nature in both parts of the simile. Consequently, concerning someone’s chance to become true philosopher, Plato’s view is quite pessimistic.
Not-Being, Contradiction and Difference. Simplicius vs. Alexander of Aphrodisias on Plato’s Conception of Not-Being
Authors: Granieri Roberto 
Published: March 2023

Abstract
In explicating a passage from Physics A 3, Simplicius reports a criticism by Alexander of Aphrodisias against Plato’s conception of not-being in the Sophist. Alexander deems this conception contradictory, because it posits that unqualified not-being is. Simplicius defends Plato and gives a diagnosis of what he regards as Alexander’s interpretative mistake in raising his objection. I unpack this debate and bring out ways in which it sheds light on important aspects of Plato’s project in the Sophist and of Simplicius’ own philosophical background, notably in Damascius’ De principiis.
The Fourth World Congress of Taiwan Studies: ‘Taiwan in the Making’, University of Washington, Seattle, 27–29 June 2022
Authors: Lee Chun-yi , Zani Beatrice 
Published: March 2023

Abstract
This report highlights and offers reflections on three unique features of the fourth World Congress of Taiwan Studies (wcts4) held in Seattle in June 2022. First, following the covid-19 pandemic, wcts4 was one of the first large-scale conferences in the field of Taiwan studies to be held in hybrid mode. Second, although three previous editions have taken place since 2012, wcts4 was the first to be held in the United States. Third, it is the first Congress to launch a major new publication, the forthcoming Encyclopedia of Taiwan Studies. Most media coverage of wcts4 has emphasised only that it was held in the United States. This report goes further, focusing on why it was held in the US, and why Seattle in particular, and on the Congress’s importance more generally to the global field of Taiwan studies.
Recent Impact of COSMIC-2 with Improved Radio Occultation Data Assimilation Algorithms
Authors: Cucurull Lidia 
Published: March 2023

Abstract
A Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC) follow-on constellation, COSMIC-2, was successfully launched into equatorial orbit on 24 June 2019. With an increased signal-to-noise ratio due to improved receivers and digital beam-steering antennas, COSMIC-2 is producing about 5000 high-quality radio occultation (RO) profiles daily over the tropics and subtropics. The initial evaluation of the impact of assimilating COSMIC-2 into NOAA’s Global Forecast System (GFS) showed mixed results, and adjustments to quality control procedures and observation error characteristics had to be made prior to the assimilation of this dataset in the operational configuration in May 2020. Additional changes in the GFS that followed this initial operational implementation resulted in a larger percentage of rejection (∼90%) of all RO observations, including COSMIC-2, in the mid- to lower troposphere. Since then, two software upgrades directly related to the assimilation of RO bending angle observations were developed. These improvements were aimed at optimizing the utilization of COSMIC-2 and other RO observations to improve global weather analyses and forecasts. The first upgrade was implemented operationally in September 2021 and the second one in November 2022. This study describes both RO software upgrades and evaluates the impact of COSMIC-2 with this most recently improved configuration. Specifically, we show that the assimilation of COSMIC-2 observations has a significant impact in improving temperature and winds in the tropics, though benefits also extend to the extratropical latitudes.
Against the use of the Strengths and Difficulties Questionnaire for Aboriginal and Torres Strait Islander children aged 2–15 years
Authors: Chau Tracey , Tiego Jeggan , Brown Louise , Coghill David , Jobson Laura , Montgomery Alicia , Murrup-Stewart Cammi , Sciberras Emma , Silk Tim J , Spencer-Smith Megan , Stefanac Nicole , Sullivan Daniel P , Bellgrove Mark A 
Published: March 2023

Objective: The Strengths and Difficulties Questionnaire is a widely used screening tool for emotional and behavioural problems in children. Recent quantitative analyses have raised concerns regarding its structural validity in Aboriginal and Torres Strait Islander communities. This paper aims to extend upon existing findings by analysing the factor structure of both the parent- and teacher-reported Strengths and Difficulties Questionnaire in this population across a broader age range than in previous studies. Methods: Participants were the caregivers and teachers of 1624 Aboriginal and Torres Strait Islander children (820 male, 804 female) aged 2–15 years from Waves 2–11 of the Longitudinal Study of Indigenous Children. The majority of children were Aboriginal living in major cities and inner regional areas. Internal consistency was estimated with McDonald’s Omega. Exploratory structural equation modelling was conducted to investigate the factor structure of the parent-reported and teacher-reported versions of the Strengths and Difficulties Questionnaire. Results: Responses from teachers demonstrated higher internal consistency than responses from parents, which was unacceptably low across most age groups. The purported five-factor structure of the Strengths and Difficulties Questionnaire failed to be replicated across both parent- and teacher-reported questionnaires. The results of bifactor and hierarchical exploratory structural equation models also failed to approximate the higher-order summary scales. These results indicate that the Strengths and Difficulties Questionnaire subscales and summary scores do not provide a valid index of emotional and behavioural problems in Aboriginal and Torres Strait Islander children. Conclusion: The Strengths and Difficulties Questionnaire should not be used with Aboriginal and Torres Strait Islander children.
Incidence, Patterns, and Severity of Potential Drug Interactions Among Cancer Patients on Chemotherapy in a Tertiary Care Hospital
Authors: H.V. Anuradha , Maka Vinayak V. , Patil Prakash , C. Anupama 
Published: March 2023

Objective To study the incidence of potential drug−drug interactions (DDIs) and evaluate their pattern and severity in cancer inpatients. Materials and Methods A detailed clinical data and prescriptions of 150 inpatients with different malignancies were subjected to DDI screening using Micromedex software. The frequency of potential DDIs and their types, patterns, and severity were investigated. Results A total of 360 potential DDIs were present in 111 (74%) of 150 inpatients, dominated by female (67.33%) and breast cancer (30%) patients. The incidence of severe interactions was 63.88%, moderate interactions 35.83%, and mild interactions 0.27%. The potential mechanisms of DDIs were 38.33% pharmacodynamic, 48.33% pharmacokinetic, and 13.33% unspecified. The drug interactions were found to be positively correlated ( p < 0.01) with the 6–10 number of prescribed medicines. Conclusion According to this study, the number of medicines prescribed to cancer inpatients increased the chance of DDIs. As a result, the drug surveillance program could save a sizable number of patients from the potentially hazardous clinical effects of DDIs.
Factors associated with adherence and viral suppression among patients on second-line antiretroviral therapy in an urban HIV program in Kenya
Authors: Nyaboke Rose , Ramadhani Habib Omari , Lascko Taylor , Awuor Patrick , Kirui Elvis , Koech Emily , Mutisya Immaculate , Ngunu Carol , Wangusi Rebecca 
Published: March 2023

Objective: The aim of this study is to estimate the proportion of virologically suppressed People living with HIV on second-line ART and to identify factors associated with virologic suppression. With an increasing population of patients on complex second-line anti retroviral therapy (ART), understanding the factors associated with viral suppression and adherence is critical for ensured longevity of ART. Methods: A retrospective study was conducted of patients on second-line ART in 17 facilities supported by University of Maryland, Baltimore, in Nairobi, Kenya, covering the period beginning October 2016 up to August 2019. Viral suppression was defined as viral load <1000 copies/mL in a test conducted in the last 12 months. Adherence was assessed through self-reports and classified as optimal (good) or suboptimal (inadequate/poor). Associations were presented as adjusted risk ratios with 95% confidence intervals. Statistical significance was considered when p value ⩽0.05. Results: Of 1100 study participants with viral load data, 974 (88.5%) reported optimal adherence while on first-line ART and 1029 (93.5%) reported optimal adherence to second-line ART. Overall, viral load suppression on second-line ART was 90%. Optimal adherence ((adjusted risk ratio) 1.26; 95% confidence interval 1.09–1.46)) and age 35–44 versus 15–24 years ((adjusted risk ratio) 1.06; 95% confidence interval 1.01–1.13)) were associated with viral suppression . Adherence to first-line ART ((adjusted risk ratio) 1.19; 95% confidence interval 1.02–1.40)) was associated with adherence to second-line ART. Conclusion: Viral suppression remains high and adherence was strongly associated with viral suppression, underscoring the need to adequately address the barriers to adherence before switching regimens.
Central retinal vein occlusion associated with Bartonella henselae infection
Authors: Bellur Sunil , Ali Amir , Nguyen Nam V. , Fernandes Joshua K. , Kodati Shilpa 
Published: March 2023

Abstract
Purpose
To report the clinical features and treatment course of a case of central retinal vein occlusion (CRVO) as the initial sign of ocular Bartonella henselae (B. henselae) infection.

Observation
A 36-year-old male was evaluated for unilateral vision loss. He denied prodromal symptoms but reported prior exposure to fleas. Best corrected visual acuity (BCVA) was 20/400 in the left eye. Clinical examination revealed a CRVO with atypical features including significant peripapillary exudates and peripheral vascular sheathing. Laboratory testing revealed elevated B. henselae IgG titers (1:512) with no abnormalities on hypercoagulability testing. The patient was treated with doxycycline and aflibercept with an excellent clinical response and improvement in BCVA to 20/25 in the left eye two months later.

Conclusion
CRVO is a rare but sight-threatening complication of ocular bartonellosis and can be the presenting sign of infection, even in the absence of cat exposure or prodromal symptoms.
CenFind: a deep-learning pipeline for efficient centriole detection in microscopy datasets
Authors: Bürgy Léo , Weigert Martin , Hatzopoulos Georgios , Minder Matthias , Journé Adrien , Rahi Sahand Jamal , Gönczy Pierre 
Published: March 2023

Abstract
Background
High-throughput and selective detection of organelles in immunofluorescence images is an important but demanding task in cell biology. The centriole organelle is critical for fundamental cellular processes, and its accurate detection is key for analysing centriole function in health and disease. Centriole detection in human tissue culture cells has been achieved typically by manual determination of organelle number per cell. However, manual cell scoring of centrioles has a low throughput and is not reproducible. Published semi-automated methods tally the centrosome surrounding centrioles and not centrioles themselves. Furthermore, such methods rely on hard-coded parameters or require a multichannel input for cross-correlation. Therefore, there is a need for developing an efficient and versatile pipeline for the automatic detection of centrioles in single channel immunofluorescence datasets.

Results
We developed a deep-learning pipeline termed CenFind that automatically scores cells for centriole numbers in immunofluorescence images of human cells. CenFind relies on the multi-scale convolution neural network SpotNet, which allows the accurate detection of sparse and minute foci in high resolution images. We built a dataset using different experimental settings and used it to train the model and evaluate existing detection methods. The resulting average F1-score achieved by CenFind is > 90% across the test set, demonstrating the robustness of the pipeline. Moreover, using the StarDist-based nucleus detector, we link the centrioles and procentrioles detected with CenFind to the cell containing them, overall enabling automatic scoring of centriole numbers per cell.

Conclusions
Efficient, accurate, channel-intrinsic and reproducible detection of centrioles is an important unmet need in the field. Existing methods are either not discriminative enough or focus on a fixed multi-channel input. To fill this methodological gap, we developed CenFind, a command line interface pipeline that automates cell scoring of centrioles, thereby enabling channel-intrinsic, accurate and reproducible detection across experimental modalities. Moreover, the modular nature of CenFind enables its integration in other pipelines. Overall, we anticipate CenFind to prove critical for accelerating discoveries in the field.
REDfold: accurate RNA secondary structure prediction using residual encoder-decoder network
Authors: Chen Chun-Chi , Chan Yi-Ming 
Published: March 2023

Abstract
Background
As the RNA secondary structure is highly related to its stability and functions, the structure prediction is of great value to biological research. The traditional computational prediction for RNA secondary prediction is mainly based on the thermodynamic model with dynamic programming to find the optimal structure. However, the prediction performance based on the traditional approach is unsatisfactory for further research. Besides, the computational complexity of the structure prediction using dynamic programming is $$O(N^3)$$

O
(

N
3

)

; it becomes $$O(N^6)$$

O
(

N
6

)

for RNA structure with pseudoknots, which is computationally impractical for large-scale analysis.

Results
In this paper, we propose REDfold, a novel deep learning-based method for RNA secondary prediction. REDfold utilizes an encoder-decoder network based on CNN to learn the short and long range dependencies among the RNA sequence, and the network is further integrated with symmetric skip connections to efficiently propagate activation information across layers. Moreover, the network output is post-processed with constrained optimization to yield favorable predictions even for RNAs with pseudoknots. Experimental results based on the ncRNA database demonstrate that REDfold achieves better performance in terms of efficiency and accuracy, outperforming the contemporary state-of-the-art methods.
A case report of an atypical haemolytic uremic syndrome in pregnancy: something wicked this way comes
Authors: Catarci Stefano , Zanfini Bruno Antonio , Di Muro Mariangela , Capone Emanuele , Frassanito Luciano , Santantonio Maria Teresa , Draisci Gaetano 
Published: March 2023

Abstract
Background
Atypical Haemolytic Uremic Syndrome is an acute life-threatening condition, characterized by the clinical triad of microangiopathic hemolytic anaemia, thrombocytopenia, kidney injury. Management of pregnants affected by Atypical Haemolytic Uremic Syndrome can be a serious concern for obstetric anesthesiologist in the delivery room and in the intensive care unit.

Case presentation
A 35-year-old primigravida with a monochorionic diamniotic twin pregnancy, presented with an acute haemorrhage due to retained placenta after elective caesarean section and underwent surgical exploration. In the postoperative period, the patient progressively developed hypoxemic respiratory failure and, later on, anaemia, severe thrombocytopenia, and acute kidney injury. A timely diagnosis of Atypical Haemolytic Uremic Syndrome was made.
Non-invasive ventilation and high-flow nasal cannula oxygen therapy sessions were initially required. Hypertensive crisis and fluid overload were aggressively treated with a combination of beta and alpha adrenergic blockers (labetalol 0,3 mg/kg/h by continuous intravenous infusion for the first 24 hours, bisoprolol 2,5 mg twice daily for the first 48 hours, doxazosin 2 mg twice daily), central sympatholytics (methyldopa 250 mg twice daily for the first 72 hours, transdermal clonidine 5 mg by the third day), diuretics (furosemide 20 mg three times daily), calcium antagonists (amlodipine 5 mg twice daily).
Eculizumab 900 mg was administered via intravenous infusion once per week, attaining hematological and renal remissions. The patient also received several blood transfusion units and anti- meningococcal B, anti-pneumococcal, anti-haemophilus influenzae type B vaccination.
Her clinical condition progressively improved, and she was finally discharged from intensive care unit 5 days after admission.

Conclusions
The clinical course of this report underlines how crucial it is for the obstetric anaesthesiologist to promptly identify Atypical Haemolytic Uremic Syndrome, since early initiation of eculizumab, together with supportive therapy, has a direct effect on patient outcome.
Response to COVID-19 recommended preventive behavioral messages among Guraghe zone communities, South Ethiopia: using constructs of the Extended Parallel Process Model (EPPM)
Authors: Kemal Abdurezak , Assfa Kenzudin , Zeleke Bisrat , Jemal Mohammed , Jemal Musa , Kedir Shemsu , Zewdie Amare , Dessu Samuel , Yassin Fedila , Habtie Adane 
Published: March 2023

Abstract
Introduction
The World Health Organization declared COVID-19 is a pandemic disease. Countries should take standard measures and responses to battle the effects of the viruses. However, little is known in Ethiopia regarding the recommended preventive behavioral messages responses. Therefore, the study aimed to assess the response to COVID-19 recommended preventive behavioral messages.

Methods
Community-based cross-sectional study design was carried out from 1 to 20, July 2020. We recruited 634 respondents by using a systematic sampling method. Data were analyzed using Statistical Package Software for Social Sciences version 23. Association between variables were explored using a bivariable and multi variable logistic regression model. The strength of the association is presented using odds ratio and regression coefficient with 95% confidence interval. A p-value of less than 0.05 was declared statistically significant.

Results:
Three hundred thirty-six (53.1%) of respondents had good response to recommended preventive behavioral messages. The general precise rate of the knowledge questionnaire was 92.21%. The study showed that merchant was 1.86 (p ≈ 0.01) times more likely respond to COVID-19 recommended preventive behavioral messages than government-employed. Respondents who scored one unit increase for self-efficacy and response-efficacy, the odds of responding to COVID-19 recommended preventive behavioral messages were increased by 1.22 (p < 0.001), and 1.05 times (p = 0.002) respectively. Respondents who scored one unit increase to cues to action, the odds of responding to COVID-19 recommended preventive behavioral messages were 43% (p < 0.001) less likely.

Conclusion
Even though respondents were highly knowledgeable about COVID-19, there is a lower level of applying response to recommended preventive behavioral messages. Merchant, self-efficacy, response efficacy, and cues to action were significantly associated with response to recommended preventive behavioral messages. Like merchants, government employer should be applying preventive behavioral messages and also, participants’ self and response efficacy should be strengthened to improve the response. In addition, we should be changed or modified the way how-to deliver relevant information, promoting awareness, and also using appropriate reminder systems to preventive behavioral messages.