bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interspecific association of sika deer in terrestrial animal communities of Liancheng National Nature Reserve, China
Authors: SU Tengwei , CUI Guofa , MAN Zihong , LI Wentao , HUANG Zhihao , CHEN Jinfeng , ZHAO Minyan 
Published: December 2022

AbstractThe prevention and control of invasive of alien species is an important work for nature reserves. This study analyzes the development trend of the alien species sika deer in Liancheng National Nature Reserve. From October 2019 to June 2020, 3523 valid photos and videos of terrestrial animals were acquired from 130 camera traps, and sika deer were recorded in 21 photos from 13 traps. The survival of the sika deer population was investigated by means of morphological identification, population structure analysis, species relative abundance indices, and species spatial association analysis. A total of 13 sika deer individuals were identified by camera trapping, including two kids and three subadults representing the reproductive capacity of the population. Spatially, sika deer is not associated with any local species and was outside the spatial association network of terrestrial animals in Liancheng National Nature Reserve, indicating that the sika deer population has not been integrated into the local community and has failed to perform its ecological function. It is worth noting that the reserve provides habitat suitable for sika deer and that the population has adequate reproductive capacity. Due to the lack of large apex predators in the reserve, the population size of ungulates such as sika deer, red deer, and Siberian roe deer may expand and lead to population outbreaks and the associated problems for the ecosystem. To restore large‐ and medium‐sized carnivores and avoid the population outbreak of the species, the present challenges require immediate attention in Liancheng National Nature Reserve.
VEXAS syndrome with severe multisystem involvement: Rapid recovery after splenectomy
Authors: Yildirim Fatih , Erdogan Mustafa , Yalcin Mutlu Melek , Akkuzu Gamze , Ozgur Duygu Sevinç , Karaalioglu Bilgin , Ayer Mesut , Bes Cemal 
Published: December 2022

AbstractVEXAS (vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic) syndrome is a newly defined disorder in which treatment is still unclear. Herein, a patient with VEXAS syndrome who had atypical findings and an interesting treatment course is presented as a case report. He had fatigue, recurrent fever, pulmonary infiltrates, proteinuria, anemia, leucopenia, transient skin rush and increased acute phase reactants. The patient, who could not tolerate corticosteroid tapering, recovered rapidly after diagnostic splenectomy and the pathological examination of the spleen revealed significant findings.
Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts
Authors: Wedel Sophia , Martic Ines , Guerrero Navarro Lena , Ploner Christian , Pierer Gerhard , Jansen‐Dürr Pidder , Cavinato Maria 
Published: December 2022

AbstractGrowth differentiation factor 15 (GDF15) is a stress‐responsive cytokine also known as a mitokine; however, its role in mitochondrial homeostasis and cellular senescence remained elusive. We show here that knocking down GDF15 expression in human dermal fibroblasts induced mitochondrial dysfunction and premature senescence, associated with a distinct senescence‐associated secretory phenotype. Fibroblast‐specific loss of GDF15 expression in a model of 3D reconstructed human skin induced epidermal thinning, a hallmark of skin aging. Our results suggest GDF15 to play a so far undisclosed role in mitochondrial homeostasis to delay both the onset of cellular senescence and the appearance of age‐related changes in a 3D human skin model.
AnthropoAge, a novel approach to integrate body composition into the estimation of biological age
Authors: Fermín‐Martínez Carlos A. , Márquez‐Salinas Alejandro , Guerra Enrique C. , Zavala‐Romero Lilian , Antonio‐Villa Neftali Eduardo , Fernández‐Chirino Luisa , Sandoval‐Colin Eduardo , Barquera‐Guevara Daphne Abigail , Campos Muñoz Alejandro , Vargas‐Vázquez Arsenio , Paz‐Cabrera César Daniel , Ramírez‐García Daniel , Gutiérrez‐Robledo Luis Miguel , Bello‐Chavolla Omar Yaxmehen 
Published: December 2022

AbstractAging is believed to occur across multiple domains, one of which is body composition; however, attempts to integrate it into biological age (BA) have been limited. Here, we consider the sex‐dependent role of anthropometry for the prediction of 10‐year all‐cause mortality using data from 18,794 NHANES participants to generate and validate a new BA metric. Our data‐driven approach pointed to sex‐specific contributors for BA estimation: WHtR, arm and thigh circumferences for men; weight, WHtR, thigh circumference, subscapular and triceps skinfolds for women. We used these measurements to generate AnthropoAge, which predicted all‐cause mortality (AUROC 0.876, 95%CI 0.864–0.887) and cause‐specific mortality independently of ethnicity, sex, and comorbidities; AnthropoAge was a better predictor than PhenoAge for cerebrovascular, Alzheimer, and COPD mortality. A metric of age acceleration was also derived and used to assess sexual dimorphisms linked to accelerated aging, where women had an increase in overall body mass plus an important subcutaneous to visceral fat redistribution, and men displayed a marked decrease in fat and muscle mass. Finally, we showed that consideration of multiple BA metrics may identify unique aging trajectories with increased mortality (HR for multidomain acceleration 2.43, 95%CI 2.25–2.62) and comorbidity profiles. A simplified version of AnthropoAge (S‐AnthropoAge) was generated using only BMI and WHtR, all results were preserved using this metric. In conclusion, AnthropoAge is a useful proxy of BA that captures cause‐specific mortality and sex dimorphisms in body composition, and it could be used for future multidomain assessments of aging to better characterize the heterogeneity of this phenomenon.
The combination of CD138/MUM1 dual‐staining and artificial intelligence for plasma cell counting in the diagnosis of chronic endometritis
Authors: Xiong Zhongtang , Zhang Wei , Liu Shaoyan , Liu Kai , Wang Jin , Qin Ping , Liu Yuping , Jiang Qingping 
Published: December 2022

AbstractObjectiveTo investigate the utility of combination of CD138/MUM1 dual‐staining (DS) and artificial intelligence (AI) for plasma cell (PC) counting in the diagnosis of chronic endometritis (CE).MethodsTwo hundred ninety‐eight infertile women underwent endometrial biopsy were included. In 100 women, three successive sections were cut from each paraffin‐embedded tissue block for CD138 immunohistochemical (IHC) single‐staining (SS), MUM1 SS and CD138/MUM1 DS. The prevalence of CE and the sensitivity/specificity in the diagnosis of CE with different methods was studied. These sections diagnosed as CE with DS were collected to train artificial intelligence (AI) diagnostic system. In other 198 women, their tissue sections stained with CD138/MUM1 DS were used to test the AI system in the diagnosis of CE.ResultsCD138/MUM1 DS revealed that the cell membranes and nuclei of PCs were simultaneously labelled by CD138 and MUM1, respectively. The positive rate of ECs identified by CD138/MUM1 DS (38%, 38/100) was lower than CD138 SS (52%, 52/100) and MUM1 SS (62%, 62/100) (p < .05). The sensitivity, specificity and accuracy of CD138/MUM1 DS in the diagnosis of ECs reached 100%. The sensitivity, specificity and accuracy rates of AI diagnostic system of ECs were 100%, 83.3% and 91.4%, respectively. The 17 cases over‐diagnosed as EC with the AI were corrected quickly by pathologists reviewing these false PC pictures listed by the AI.ConclusionThe combination of CD138/MUM1 DS and AI is a promising method to improve the accuracy and efficiency of CE diagnosis.
Factors associated with lower disease‐specific and generic health‐related quality of life in Rome IV irritable bowel syndrome
Authors: Goodoory Vivek C. , Guthrie Elspeth A. , Ng Cho E. , Black Christopher J. , Ford Alexander C. 
Published: December 2022

SummaryBackgroundLittle is known about associations with reduced quality of life in irritable bowel syndrome (IBS) or impact of IBS on quality of life compared with other chronic conditions.MethodsWe collected demographic, gastrointestinal and psychological symptoms, healthcare usage, direct healthcare costs, impact on work and activities of daily living data from 752 individuals with Rome IV‐defined IBS. We used the irritable bowel syndrome quality of life (IBS‐QOL) and the EQ‐5D‐5L questionnaires to examine characteristics associated with lower quality of life.ResultsThe mean IBS‐QOL among all 752 individuals with Rome IV IBS was 48.4 (SD 22.3) and the mean EQ‐5D score was 0.570 (SD 0.283), the latter being comparable to people with stroke, leg ulcers or chronic obstructive pulmonary disease. Lower levels of both disease‐specific and generic quality of life were associated with severe IBS symptom scores, abnormal anxiety or depression scores, and higher somatoform symptom‐reporting and gastrointestinal symptom‐specific anxiety scores (p < 0.001 for all analyses). Those with lower quality of life had significantly higher healthcare usage and direct healthcare costs and more impairment in work and activities of daily living (p < 0.01 for all analyses). Avoidance of alcohol, lower educational level, abnormal anxiety, depression or somatoform symptom‐reporting scores, and impairment in social leisure activities, home management or maintaining close relationships were all independently associated with lower quality of life.ConclusionIBS has a substantial impact on the quality of life of those affected, and worse than observed in some severe chronic organic conditions.
Medium chain triglycerides improve the growth performance, immune and antioxidant functions, and intestinal health of weaned rabbits
Authors: Wang Bin , Ye Xin , Guo Zhiqiang , Kuang Liangde , Yang Rui , Li Congyan , Guo Zihan , Zheng Jie , Li Yu Ying , Lei Min , Lu Jingzhi , Xie Xiaohong 
Published: December 2022

AbstractThe purpose is to study the effects of different doses of medium chain triglyceride (MCT) on growth performance, immune and oxidative functions, and intestinal health of weaned rabbits. A total of 600 weaned rabbits weighing about 993.26 g and at 35 d of age were randomly divided into five groups. The control group was fed a basal diet containing 2400 mg/kg soybean oil, and the experimental group was substituted with 600, 1200, 1800, and 2400 mg/kg MCT. The whole trial period lasted for 48 d. The results showed that treatment with 2400 mg/kg MCT significantly increased the weaning survival rate and crude fat digestibility (p < 0.05) and dramatically raised the levels of serum immunoglobulin (Ig)A, IgG, IgM, catalase, superoxide dismutase, and total antioxidant capability (p < 0.05). The villus height and crypt depth in 1800 mg/kg MCT group were observably enhanced (p < 0.05). The abundance of Bacteroidetes was significantly increased in 1800 and 2400 mg/kg MCT groups (p < 0.05). In conclusion, 1800 and 2400 mg/kg MCT substituting soybean oil in the diet of weaned rabbits can improve the growth performance and intestinal barrier function of weaned rabbits.
Treatment decision regret in long‐term survivors after radical prostatectomy: a longitudinal study
Authors: Meissner Valentin H. , Simson Barbara W. , Dinkel Andreas , Schiele Stefan , Ankerst Donna P. , Lunger Lukas , Gschwend Jürgen E. , Herkommer Kathleen 
Published: December 2022

ObjectivesTo investigate prevalence, course, and predictors of longitudinal decision regret in long‐term prostate cancer (PCa) survivors treated by radical prostatectomy (RP).Patients and MethodsA total of 1003 PCa survivors from the multicentre German Familial PCa Database completed questionnaires on average 7 years after RP in 2007 and at follow‐up 13 years later in 2020. Patients completed standardised patient‐reported outcome measures on decision regret, decision‐making, health‐related quality of life, and psychosocial factors. Hierarchical multivariable logistic regression was used to assess predictors of longitudinal decision regret.ResultsDecision regret increased significantly over time (9.0% after 6.9 years in 2007 and 12% after 19 years in 2020; P = 0.009). Favourable localised PCa (odds ratio [OR] 1.97, 95% confidence interval [CI] 1.05–3.68), decision regret in 2007 (OR 6.38, 95% CI 3.55–11.47), and a higher depression score (OR 1.37, 95% CI 1.03–1.83) were associated with decision regret in 2020. Shared decision‐making (OR 0.55, 95% CI 0.33–0.93) was associated with less decision regret.ConclusionThe findings of the present study underline the perseverance of decision regret in long‐term PCa survivors and the definitive need for involving patients in the decision‐making process to mitigate regret over the long term.
Sustainable functional urethral reconstruction improves early urinary continence after robot‐assisted radical prostatectomy: a randomised controlled trial
Authors: Jia Zepeng , Chen Zeyu , Chang Yifan , Wu Cheng , Qu Min , Nian Xinwen , Shen Xianqi , Zhang Yun , Tang Shouyan , Wang Yan , Gao Xu 
Published: December 2022

ObjectiveTo evaluate the impact of sustainable functional urethral reconstruction (SFUR) on early recovery of urinary continence (UC) after robot‐assisted radical prostatectomy.Patients and MethodsOverall, 96 patients with primary prostate cancer were randomised into the SFUR or standard group (n = 48 each). The primary outcome was the 1‐month UC recovery. Secondary outcomes included short‐term (≤3 months) UC recovery, urinary function, micturition‐related bother, perioperative complications, and oncological outcomes. Kaplan–Meier curves and Cox proportional hazard models were used to assess the 3‐month UC recovery. Generalised estimating equations were used to compare postoperative urinary function and micturition‐related bother.ResultsThe 1‐month UC recovery rates, median 24‐h pad weights, and median operative time in the SFUR and standard groups were 73% and 49% (P = 0.017), 0 and 47 g (P = 0.001), and 125 and 103 min (P = 0.025), respectively. The UC recovery rates in the SFUR vs standard groups were 53% vs 23% at 1 week (P = 0.003), 53% vs 32% at 2 weeks (P = 0.038), and 93% vs 77% at 3 months (P = 0.025). The median time to UC recovery in the SFUR and standard groups was 5 and 34 days, respectively (log‐rank P = 0.006); multivariable Cox regression supported this result (hazard ratio 1.73, 95% confidence interval 1.08–2.79, P = 0.024). Similar results were observed when UC was defined as 0 pads/day. Urinary function (P = 0.2) and micturition‐related bother (P = 0.8) were similar at all follow‐up intervals. The perioperative complication rates, positive surgical margin rates, and 1‐year biochemical recurrence‐free survival were comparable between both groups (all P > 0.05).ConclusionSFUR resulted in earlier UC recovery without compromising postoperative urinary function. Long‐term validation and multicentre studies are required to confirm the results of this novel technique.
Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region‐associated protein synthesis and TLR4/NF‐κB signaling pathway
Authors: Yilmaz Seher , Doğanyiğit Züleyha , Oflamaz Aslı Okan , Ateş Şükrü , Uçar Sümeyye , Söylemez Evrim Suna Arıkan 
Published: December 2022

AbstractIn this study, the protective effect of melatonin was investigated in lipopolysaccharide induced sepsis model. Twenty‐eight rats were randomly divided: Control, Melatonin, LPS and LPS + Melatonin. After LPS application, surgically remove kidney and liver tissues. The level of malondialdehyde (MDA) an oxidative stress marker and the immunoreactivity of Toll‐like receptor‐4 (TLR4), tumor necrosis factor‐α (TNF‐α), and transcription factor NF‐κB were evaluated immunohistochemically. Expression levels for TLR4, TNF‐α, NF‐kB, IL‐1β (interleukin 1 beta), and IL‐6 (interleukin 6) were evaluated. Additionally, Argyrophilic NOR staining was performed in tissues. Vacuolization and inflammation were more intense in the kidney and liver sections in the LPS group compared to the other groups. It was observed that vacuolization and inflammation were decreased in LPS + Melatonin applied groups. It was determined that glomerular damage was increased in the LPS and LPS‐melatonin groups, but the damage rate LPS‐Melatonin group was decrease in the LPS group. It was determined that the MDA level in tissues of the LPS group was importantly increased compared to other groups. Additionally, TAA/NA ratio statistically significant differences were discovered between the groups. This study supports the potential protective effects of 10 mg/kg melatonin by modulating critical markers of local immune reaction in a model of LPS‐induced sepsis.
The incidence of extraction site incisional hernia after minimally invasive colorectal surgery: a systematic review and meta‐analysis
Authors: den Hartog Floris P. J. , van Egmond Sarah , Poelman Marijn M. , Menon Anand G. , Kleinrensink Gert‐Jan , Lange Johan F. , Tanis Pieter J. , Deerenberg Eva B. 
Published: December 2022

AbstractAimMinimally invasive colorectal surgery reduces surgical trauma with better preservation of abdominal wall integrity, but the extraction site is still at risk of incisional hernia (IH). The aim of this study was to determine pooled incidence of IH for each type of extraction site and to compare rates of IH after midline, nonmidline and Pfannenstiel extraction.MethodA systematic review and meta‐analysis was conducted using the PRISMA guidelines. Single‐armed and multiple‐armed cohort studies and randomized controlled trials regarding minimally invasive colorectal surgery were searched from five databases. Outcomes were pooled and compared with random‐effects, inverse‐variance models. Risk of bias within the studies was assessed using the Cochrane ROBINS‐I and RoB 2 tool.ResultsThirty six studies were included, with a total 11,788 patients. The pooled extraction site IH rate was 16.0% for midline (n = 4081), 9.3% for umbilical (n = 2425), 5.2% for transverse (n = 3213), 9.4% for paramedian (n = 134) and 2.1% for Pfannenstiel (n = 1449). Nonmidline extraction (transverse and paramedian) showed significantly lower odds ratios (ORs) for IH when compared with midline extraction (including umbilical). Pfannenstiel extraction resulted in a significantly lower OR for IH compared with midline [OR 0.12 (0.50–0.30)], transverse [OR 0.25 (0.13–0.50)] and umbilical (OR 0.072 [0.033–0.16]) extraction sites. The risks of surgical site infection, seroma/haematoma or wound dehiscence were not significantly different in any of the analyses.ConclusionPfannenstiel extraction is the preferred method in minimally invasive colorectal surgery. In cases where Pfannenstiel extraction is not possible, surgeons should avoid specimen extraction in the midline.
Trends in organ donation and transplantation over the past eighteen years in Iran
Authors: Shadnoush Mahdi , Latifi Marzieh , Rahban Habib , Pourhosein Elahe , Shadnoush Alireza , Jafarian Arefeh , Dehghani Sanaz 
Published: December 2022

AbstractBackgroundThis article will review the trends in organ donation over the past 18 years in Iran.Material and methodsAll donation and transplantation statistics were extracted by reviewing the Organ Procurement and Transplantation database of the Ministry of Health of Iran from 2002 to 2019.ResultsIran's national deceased donation rate from 2002 to 2019 increased 19.06‐fold from .75 to 14.3 per million population (PMP). After the beginning of the COVID‐19 pandemic, the rate of organ donation in Iran decreased significantly. Although 1 year after the onset of the pandemic, due to the widespread adoption of COVID19 vaccination, the rate of organ donation began to increase again, this system is still under performing. During the years under examination, the rate of deceased kidney donation increased significantly compared to living kidney donation and reached up to 2001 kidney transplantations in 2021. From 2002 to 2019, the rate of liver transplants increased to 12.8. Likewise, the rate of heart transplants increased 8.4‐fold, from 15 to 126 cases during the same time.ConclussionAlthough a personal choice, the process of organ donation involves medical, legal, ethical, organizational, and social aspects. The trend in increasing donation rates over the past years can be attributed to multiple influences, which include rigorous team efforts in the organ donation and transplantation systems, in addition to creating a donation culture and promoting donation through media platforms. Moreover, we can say that the rising rates of deceased donor transplantation also can drive down rates of commercial living donor transplantation.
IMpact of flash glucose Monitoring in pEople with type 2 Diabetes Inadequately controlled with non‐insulin Antihyperglycaemic ThErapy (IMMEDIATE): A randomized controlled trial
Authors: Aronson Ronnie , Brown Ruth E. , Chu Lisa , Bajaj Harpreet S. , Khandwala Hasnain , Abitbol Alexander , Malakieh Nadia , Goldenberg Ronald 
Published: December 2022

AbstractAimTo examine the efficacy and patient satisfaction of intermittently scanned continuous glucose monitoring (isCGM) in adults using non‐insulin therapies for the management of type 2 diabetes.Materials and MethodsThe IMMEDIATE study was a multisite, open label, randomized controlled trial with follow‐up at 16 weeks. Adults with type 2 diabetes using at least one non‐insulin therapy, with an HbA1c of 7.5% or higher (≥ 58 mmol/mol), were randomized 1:1 to receive an isCGM device plus diabetes self‐management education (isCGM + DSME) or DSME alone. Enrolment occurred from 8 September 2020 to 24 December 2021. The primary outcome was percentage mean time in range (TIR), in the final 2‐week period, measured via blinded CGM.ResultsOne hundred and sixteen participants were randomized (mean age, 58 years; diabetes duration, 10 years; mean HbA1c, 8.6% [70 mmol/mol]). At 16 weeks of follow‐up, the isCGM and DSME arm had a significantly greater mean TIR by 9.9% (2.4 hours) (95% CI, −17.3% to −2.5%; P < .01), significantly less time above range by 8.1% (1.9 hours) (95% CI, 0.5% to 15.7%; P = .037), and a greater reduction in mean HbA1c by 0.3% (3 mmol/mol) (95% CI, 0% to 0.7%; P = .048) versus the DSME arm. Time below range was low and not significantly different between groups and hypoglycaemic events were few in both groups. Glucose monitoring satisfaction was higher among isCGM users (adjusted difference −0.5 [95% CI, −0.7 to −0.3], P < .01).ConclusionsThe IMMEDIATE study has shown that among non‐insulin–treated individuals with type 2 diabetes, use of isCGM is associated with an improvement in glycaemic outcomes.