bluuebunny/crossref_metadata_2025_split huggingface dataset:
An investigation of treatment return after psychological therapy for depression and anxiety
Authors: Lorimer Ben , Kellett Stephen , Giesemann Julia , Lutz Wolfgang , Delgadillo Jaime 
Published: August 2023

AbstractBackground:Some patients return for further psychological treatment in routine services, although it is unclear how common this is, as scarce research is available on this topic.Aims:To estimate the treatment return rate and describe the clinical characteristics of patients who return for anxiety and depression treatment.Method:A large dataset (N=21,029) of routinely collected clinical data (2010–2015) from an English psychological therapy service was analysed using descriptive statistics.Results:The return rate for at least one additional treatment episode within 1–5 years was 13.7%. Furthermore, 14.5% of the total sessions provided by the service were delivered to treatment-returning patients. Of those who returned, 58.0% continued to show clinically significant depression and/or anxiety symptoms at the end of their first treatment, while 32.0% had experienced a demonstrable relapse before their second treatment.Conclusions:This study estimates that approximately one in seven patients return to the same service for additional psychological treatment within 1–5 years. Multiple factors may influence the need for additional treatment, and this may have a major impact on service activity. Future research needs to further explore and better determine the characteristics of treatment returners, prioritise enhancement of first treatment recovery, and evaluate relapse prevention interventions.
Cost considerations for implementing dignity therapy in palliative care: Insights and implications
Authors: Al Yacoub Raed , Rangel Andrea P. , Shum-Jimenez Adriana , Greenlee Amelia , Yao Yingwei , Schoppee Tasha M. , Fitchett George , Handzo George , Chochinov Harvey Max , Emanuel Linda L. , Kittelson Sheri , Wilkie Diana J. 
Published: August 2023

AbstractObjectivesDespite the clinical use of dignity therapy (DT) to enhance end-of-life experiences and promote an increased sense of meaning and purpose, little is known about the cost in practice settings. The aim is to examine the costs of implementing DT, including transcriptions, editing of legacy document, and dignity-therapists’ time for interviews/patient’s validation.MethodsAnalysis of a prior six-site, randomized controlled trial with a stepped-wedge design and chaplains or nurses delivering the DT.ResultsThe mean cost per transcript was $84.30 (SD = 24.0), and the mean time required for transcription was 52.3 minutes (SD = 14.7). Chaplain interviews were more expensive and longer than nurse interviews. The mean cost and time required for transcription varied across the study sites. The typical total cost for each DT protocol was $331–$356.Significance of resultsDT implementation costs varied by provider type and study site. The study’s findings will be useful for translating DT in clinical practice and future research.
Community-based participatory climate action
Authors: Restrepo-Mieth Andrea , Perry Jocelyn , Garnick Jonah , Weisberg Michael 
Published: August 2023

Non-technical summary
Improving the flow of information between governments and local communities is paramount to achieving effective climate change mitigation and adaptation. We propose five pathways to deepen participation and improve community-based climate action. The pathways can be summarized as visualization, simulations to practice decision-making, participatory budgeting and planning, environmental civic service, and education and curriculum development. These pathways contribute to improving governance by consolidating in governments the practice of soliciting and incorporating community participation while simultaneously giving communities the tools and knowledge needed to become active contributors to climate change adaptation and mitigation measures.

Technical summary
Community participation is considered a key component in the design of responses to climate change. Substantial engagement of local communities is required to ensure information flow between governments and communities, but also because local communities are the primary sites of adaptation action. However, frontline communities are often excluded from decision-making and implementation processes due to political choices or failures to identify ways to make participatory frameworks more inclusive. Climate action requires the active engagement of communities in making consequential decisions, or what we term deepened participation. We propose five pathways to deepen participation: visualization, simulations to practice decision-making, participatory budgeting and planning, environmental civic service, and education and curriculum development. The five pathways identify strategies that can be incorporated into existing organizational and institutional frameworks or used to create new ones. Shortcomings related to each strategy are identified. Reflection by communities and governments is encouraged as they choose which participatory technique(s) to adopt.

Social media summary
Climate action requires the active engagement of communities. Learn five pathways to get started deepening participation.
Dynasonde Observations of Ionospheric Polar Holes Under Quiet Geomagnetic Conditions at Jang Bogo Station, Antarctica
Authors: Kim Khan‐Hyuk , Kim Dong‐Hee , Back Junho , Kwon Hyuck‐Jin , Jee Geonhwa , Ham Young‐Bae , Lee Changsup , Kim Jeong‐Han 
Published: August 2023

AbstractNoticeable F‐region electron density (NmF2) depletions were observed in the winter‐nighttime polar cap ionosphere during solar minimum from the Vertical Incidence Pulsed Ionospheric Radar (VIPIR) with Dynasonde analysis at Jang Bogo Station (JBS) in Antarctica. We focus on the F‐region density depletion events (known as polar holes) following a steady quiet condition that is defined with Kp values ≤ 1+ during 6 hr. Forty‐five polar holes were identified by JBS VIPIR/Dynasonde (JVD) in 2019. All of the events started over a wide range of nightside magnetic local time (22‐05 MLT) with a peak occurrence at 01–03 MLT. JVD measured exponential NmF2 decrease in the nightside MLT (∼19–2.5 hr) zone with e‐fold decay times distributed in the range of ∼0.5–∼3.5 hr before the onset of a polar hole. The e‐folding times decrease along the longitude from dusk toward midnight. The horizontal ion drift velocity (Vhor) estimated from JVD monotonically goes down from ∼190 m/s at 18 MLT to ∼100 m/s near magnetic midnight, and the NmF2 is depleted as Vhor decreases prior to the polar hole formation. The observations of the exponential NmF2 decrease and the positive correlation between NmF2 and Vhor prior to the polar holes are discussed in light of possible formation mechanisms of polar holes, including temporal variations and spatial structure of the polar ionosphere.
Coevolution of Flood Dynamics and Economical Production in Tropical Wetlands: Insights From Bayesian Networks in Ayapel Wetland, Colombia
Authors: Herazo S. , Berrouet L. , Hernández‐Atilano E. , Agudelo‐Echavarría D. M. 
Published: August 2023

AbstractThe coevolution approach in socio‐hydrological systems (SHS) allows the analysis of the interactions between social and hydrological systems over time. SHS's characteristics such as non‐linearity, causality, integration of spatiotemporal scales and feedbacks must be considered. However, in simulation processes, there are challenges in analyzing these characteristics while integrating quantitative and qualitative source variables. We propose a general causal network for study of coevolution in tropical wetlands, operationalized through Bayesian Networks for a case study in Ayapel Wetland, Colombia. We defined the flood pulse and economic production to analyze the co‐evolution of tropical wetlands. We identified that the probability of having more than 146,998 individuals of livestock is 30% and of obtaining a fish production considered “high” by fishers is 44.2% for a period from 1995 to 2019. However, under permanent conditions, the probability of this livestock decreases to 18.7%, and “high” fishing increases to 87.5%. Under seasonal conditions, the probability of high livestock production increases to 42.8%, and fish production decreases to 3.85%. We demonstrated how the loss of functionality of the existing hydraulic technology in the study area modifies the production dynamics and how a maximum level of agricultural and livestock production is associated with an increase in forest and grassland cover. We consider that the application of the network strengthens adaptation strategies for climate change or The El Niño‐Southern Oscillation events, the risk management plans and land use decision plans in the tropical wetlands.
Distinct Modes of Aged Soil Carbon Export in a Large Tropical Lake Basin Identified Using Bulk and Compound‐Specific Radiocarbon Analyses of Fluvial and Lacustrine Sediment
Authors: Parker Wesley G. , Ahad Jason M. E. , Obrist‐Farner Jonathan , Keenan Benjamin , Douglas Peter M. J. 
Published: August 2023

AbstractThe 14C content of sedimentary organic matter (OM) and specific organic molecules provide valuable information on the source and age of OM stored in sediments, but these data are limited for tropical fluvial and lake sediments. We analyzed 14C in bulk OM, palmitic acid (C16), and long‐chain n‐alkanoic acids (C24, C26, and C28), within fluvial and lake sediments in the catchment of Lake Izabal, a large tectonic lake basin in Guatemala. We combined these measurements with bulk and compound‐specific δ13C measurements, as well as sediment organic carbon to nitrogen (OC:N) ratios, to understand the source and age of sedimentary OM in different regions of the lake catchment. Most fatty acid and bulk OM samples were characterized by pre‐modern carbon, indicating important input of aged carbon with residence times of hundreds to thousands of years into sediments. We identified two mechanisms leading to aged carbon export to sediments. In the high‐relief and deforested Polochic catchment, older OM and fatty acids are associated with low % total organic carbon (TOC) and low OC:N, indicating aged OM associated with eroded mineral soil. In the smaller, low‐relief, and largely forested Oscuro catchment, old OM and fatty acids are associated with high %TOC and high OC:N ratios, indicating export of undegraded aged plant biomass from swamp peat. The age of bulk OM and fatty acids in Lake Izabal sediments is similar to the ages observed in fluvial sediments, implying that fluvial input of aged soil carbon makes an important contribution to lake sediment carbon reservoirs in this large tropical lake.
Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCIIhi neutrophils
Authors: Ma Teng , Tang Yu , Wang Taolin , Yang Yang , Zhang Yige , Wang Ruihuan , Zhang Yongxin , Li Yi , Wu Mingbo , Tang Miao , Hu Xueli , Zou Chaoyu , Ren Yuan , Liu Huan , Zhang Qianhua , Li Heyue , Wu Min , Li Jing , Zhou Xikun 
Published: August 2023

AbstractBreast cancer can metastasize to various organs, including the lungs. The immune microenvironment of the organs to be metastasized plays a crucial role in the metastasis of breast cancer. Infection with pathogens such as viruses and bacteria can alter the immune status of the lung. However, the effect of chronic inflammation caused by bacteria on the formation of a premetastatic niche within the lung is unclear, and the contribution of specific immune mediators to tumor metastasis also remains largely undetermined. Here, we used a mouse model revealing that chronic pulmonary bacterial infection augmented breast cancer lung metastasis by recruiting a distinct subtype of tumor-infiltrating MHCIIhi neutrophils into the lung, which exhibit cancer-promoting properties. Functionally, MHCIIhi neutrophils enhanced the lung metastasis of breast cancer in a cell-intrinsic manner. Furthermore, we identified CCL2 from lung tissues as an important environmental signal to recruit and maintain MHCIIhi neutrophils. Our findings clearly link bacterial-immune crosstalk to breast cancer lung metastasis and define MHCIIhi neutrophils as the principal mediator between chronic infection and tumor metastasis.
Identification of an intronic enhancer regulating RANKL expression in osteocytic cells
Authors: Yan Minglu , Tsukasaki Masayuki , Muro Ryunosuke , Ando Yutaro , Nakamura Kazutaka , Komatsu Noriko , Nitta Takeshi , Okamura Tadashi , Okamoto Kazuo , Takayanagi Hiroshi 
Published: August 2023

AbstractThe bony skeleton is continuously renewed throughout adult life by the bone remodeling process, in which old or damaged bone is removed by osteoclasts via largely unknown mechanisms. Osteocytes regulate bone remodeling by producing the osteoclast differentiation factor RANKL (encoded by the TNFSF11 gene). However, the precise mechanisms underlying RANKL expression in osteocytes are still elusive. Here, we explored the epigenomic landscape of osteocytic cells and identified a hitherto-undescribed osteocytic cell-specific intronic enhancer in the TNFSF11 gene locus. Bioinformatics analyses showed that transcription factors involved in cell death and senescence act on this intronic enhancer region. Single-cell transcriptomic data analysis demonstrated that cell death signaling increased RANKL expression in osteocytic cells. Genetic deletion of the intronic enhancer led to a high-bone-mass phenotype with decreased levels of RANKL in osteocytic cells and osteoclastogenesis in the adult stage, while RANKL expression was not affected in osteoblasts or lymphocytes. These data suggest that osteocytes may utilize a specialized regulatory element to facilitate osteoclast formation at the bone surface to be resorbed by linking signals from cellular senescence/death and RANKL expression.
Subtelomeric 5-enolpyruvylshikimate-3-phosphate synthase copy number variation confers glyphosate resistance in Eleusine indica
Authors: Zhang Chun , Johnson Nicholas A. , Hall Nathan , Tian Xingshan , Yu Qin , Patterson Eric L. 
Published: August 2023

AbstractGenomic structural variation (SV) has profound effects on organismal evolution; often serving as a source of novel genetic variation. Gene copy number variation (CNV), one type of SV, has repeatedly been associated with adaptive evolution in eukaryotes, especially with environmental stress. Resistance to the widely used herbicide, glyphosate, has evolved through target-site CNV in many weedy plant species, including the economically important grass, Eleusine indica (goosegrass); however, the origin and mechanism of these CNVs remain elusive in many weed species due to limited genetic and genomic resources. To study this CNV in goosegrass, we present high-quality reference genomes for glyphosate-susceptible and -resistant goosegrass lines and fine-assembles of the duplication of glyphosate’s target site gene 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). We reveal a unique rearrangement of EPSPS involving chromosome subtelomeres. This discovery adds to the limited knowledge of the importance of subtelomeres as genetic variation generators and provides another unique example for herbicide resistance evolution.
Elevated binding and functional antibody responses to SARS-CoV-2 in infants versus mothers
Authors: Stoddard Caitlin I. , Sung Kevin , Yaffe Zak A. , Weight Haidyn , Beaudoin-Bussières Guillaume , Galloway Jared , Gantt Soren , Adhiambo Judith , Begnel Emily R. , Ojee Ednah , Slyker Jennifer , Wamalwa Dalton , Kinuthia John , Finzi Andrés , Matsen Frederick A. , Lehman Dara A. , Overbaugh Julie 
Published: August 2023

AbstractInfant antibody responses to viral infection can differ from those in adults. However, data on the specificity and function of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in infants, and direct comparisons between infants and adults are limited. Here, we characterize antibody binding and functionality against Wuhan-Hu-1 (B lineage) strain SARS-CoV-2 in convalescent plasma from 36 postpartum women and 14 of their infants infected with SARS-CoV-2 from a vaccine-naïve prospective cohort in Nairobi, Kenya. We find significantly higher antibody titers against SARS-CoV-2 Spike, receptor binding domain and N-terminal domain, and Spike-expressing cell-surface staining levels in infants versus mothers. Plasma antibodies from mothers and infants bind to similar regions of the Spike S2 subunit, including the fusion peptide (FP) and stem helix-heptad repeat 2. However, infants display higher antibody levels and more consistent antibody escape pathways in the FP region compared to mothers. Finally, infants have significantly higher levels of antibody-dependent cellular cytotoxicity (ADCC), though, surprisingly, Spike pseudovirus neutralization titers between infants and mothers are similar. These results suggest infants develop distinct SARS-CoV-2 binding and functional antibody activities and reveal age-related differences in humoral immunity to SARS-CoV-2 infection that could be relevant to protection and COVID-19 disease outcomes.
In-situ self-crosslinking strategy for autonomous self-healing materials
Authors: Song Yan , Kong Annan , Chen Dongxiang , Li Guo Liang 
Published: August 2023

AbstractAutonomous self-healing anticorrosion protective coatings from intrinsic polymers is a great challenge. In this work, in-situ self-crosslinking strategy was demonstrated for constructing self-healing anticorrosion polymers. The as-synthesized polymers had tunable catechol content and mechanical properties. The specimens could be repaired in an Fe3+ solution owing to the formation of dynamic catechol-Fe3+ coordination crosslinking sites. Moreover, when scratched, the prepared polymers exhibited a self-healing anticorrosion performance, as evidenced by salt immersion and electrochemical impedance spectroscopy. An in-situ self-crosslinking mechanism was proposed, which was derived from the dynamic coordination of catechol groups in the polymer chains and Fe3+ produced from the metal substrate. This intrinsic self-healing anticorrosion polymer are highly potential for anticorrosion applications in harsh environments.
Coherent memory for microwave photons based on long-lived mechanical excitations
Authors: Liu Yulong , Liu Qichun , Sun Huanying , Chen Mo , Wang Shuaipeng , Li Tiefu 
Published: August 2023

AbstractMechanical resonators, due to their capability to host ultralong-lived phonon modes, are particularly attractive for quantum state storage and as memory elements in conjunction with quantum computing and communication networks. Here we demonstrate absorptive-type coherent memory based on long-lived mechanical excitations. The itinerant coherent microwave field is captured, stored, and retrieved from a mechanical memory oscillator which is pre-cooled to the ground state. The phase space distribution allows us to distinguish between coherent and thermal components and study their evolution as a function of storage time. Our device exhibits attractive functions with an energy decay time of T1 = 15.9 s, a thermal decoherence rate of Γth = 2.85 Hz, and acquires less than one quantum noise during the τcoh = 55.7 ms storage period. We demonstrate that both the amplitude and phase information of microwave coherent states can be recovered, indicating the coherence of our memory device. These results suggest that high-Q mechanical resonators and long coherence time phonons could be ideal candidates for the construction of long-lived and on-demand microwave quantum memories.
A multi-modal panel dataset to understand the psychological impact of the pandemic
Authors: van der Vegt Isabelle , Kleinberg Bennett 
Published: August 2023

AbstractBesides far-reaching public health consequences, the COVID-19 pandemic had a significant psychological impact on people around the world. To gain further insight into this matter, we introduce the Real World Worry Waves Dataset (RW3D). The dataset combines rich open-ended free-text responses with survey data on emotions, significant life events, and psychological stressors in a repeated-measures design in the UK over three years (2020: n = 2441, 2021: n = 1716 and 2022: n = 1152). This paper provides background information on the data collection procedure, the recorded variables, participants’ demographics, and higher-order psychological and text-derived variables that emerged from the data. The RW3D is a unique primary data resource that could inspire new research questions on the psychological impact of the pandemic, especially those that connect modalities (here: text data, psychological survey variables and demographics) over time.
Proximate, minerals, carotenoid and trypsin inhibitor composition in the exoskeletons of seafood gastropods and their potentials for sustainable circular utilisation
Authors: Elegbede Isa Olalekan , Lawal-Are Aderonke , Oloyede Rashidat , Sanni Rukayat Oluwatayo , Jolaosho Toheeb Lekan , Goussanou Appolinaire , Ngo-Massou Vanessa Maxemilie 
Published: August 2023

AbstractPeriwinkle shells ofTympanotonus fuscatus,Pachymelania aurita, andThais coronatawere analyzed for their proximate composition, nutritionally significant minerals, trypsin inhibitors, and carotenoids. The mean values obtained were compared using an ANOVA test.The results showed thatT. fuscatushad the highest mean moisture content of 0.96 ± 0.14% and a mean value of 0.49 ± 0.13% for crude fibre but was not significantly different (P > 0.05) fromP. auritus. The crude protein and fibre content ofT. fuscatuswas significantly higher (P < 0.05) than other periwinkle samples.T. coronatahad the highest mean total ash content and was significantly different (p < 0.05) from other periwinkle samples.T. fuscatushad the highest mean value for Mg (0.32 ± 0.03 mg/kg) and differed significantly (P < 0.05). The mean Ca content ofP. auritawas not significantly different (P > 0.05) from that ofT. coronata. The mean values of CaCO3inT. fuscatus, P. aurita, and T. coronatawere 57.20 ± 2.46, 59.50 ± 3.23, and 62.36 ± 1.56 (mg/kg), respectively.T. coronatawas significantly different (P < 0.05) from other periwinkle samples. The mean values of carotenoids inT. fuscatus,P. aurita, andT. coronatawere 7.17 ± 2.14, 18.00 ± 5.27, and 11.20 ± 3.60 (mg/kg), respectively, andP. auritawas significantly different (P < 0.05) from other periwinkle samples.T. fuscatusandP. auritahad shells with significant amounts of trypsin inhibitor (23.30 ± 4.50 mg/kg and 22.90 ± 14.10 mg/kg, respectively), making them less suitable for livestock feed. In contrast,T. coronatahad a lower mean value of 11.80 ± 7.19 mg/kg for trypsin inhibitor, making it an excellent addition to livestock feed. The low crude fibre and fat contents of the periwinkle samples in this study make them suitable for processing complementary foods, especially for hypertensive patients. The high percentage of CaCO3in periwinkle shells makes them a probable source used in the production of slurry for chromatography. The findings suggest that periwinkle shells contain specific minerals that can be applied in numerous industries. Increased use of these gastropod shells will result in successful application in product creation and a sustainable bio-circular economy.