bluuebunny/crossref_metadata_2025_split huggingface dataset:
Madhuca-longifolia-hydro-ethanolic-fraction reverses mitochondrial dysfunction and modulates selective GLUT expression in diabetic mice fed with high-fat-diet
Authors: Jha Dhruv , Prajapati Santosh Kumar , Deb Prashant , jaiswal mohit , Majumder Papiya Mitra 
Published: July 2023

Abstract
Metabolic disorders are characterized by chronic mild inflammation that elevates circulatory inflammatory markers. The proposed hypothesis behind this includes the occurrence of mitochondrial dysfunction, oxidative stress, and hypoxia due to a high-fat diet (HFD). In the present study, the effect of madhuca-longifolia-hydro-ethanolic-fraction (MLHEF) on HFD-induced obesity and diabetes through mitochondrial action and selective GLUT expression was studied. In this study, it was observed that chronic administration of HFD (50% of diet) aggravated metabolic problems by reducing ATP production, imbalanced oxidative stress, and altered GLUT expression. Chronic HFD administration significantly reduced (p < 0.001) the superoxide dismutase (SOD) and catalase (CAT) levels, as well as elevated the liver function markers aspartate aminotransferase (AST) and alanine aminotransferase (ALT). MLHEF administration reduces oxidative stress. HFD administration also decreased the ATP/ADP ratio owing to mitochondrial dysfunction and elevated lactose dehydrogenase (LDH) levels. This imbalance leads to altered GLUT expression in hepatocytes, skeletal muscles, and adipose tissue. HFD significantly (p < 0.001) upregulated in the GLUT 1 and 3 expression while significant downregulation (p < 0.001) was observed in GLUT 2 and 4 expression in the liver, skeletal muscles, and adipose tissue. Administration of MLHEF significantly (p < 0.001) reduced LDH levels and mitochondrial dysfunction. The imbalance in GLUT levels was significantly reversed to maintain GLUT expression in tissues following MLHEF administration.
Network Pharmacology Reveals the Potential of Dolastatin 16 as Diabetic Wound Healing Agent
Authors: Luthfiana Dewi , Utomo Didik Huswo 
Published: July 2023

Abstract
Dolastatin 16, a marine cyclic depsipeptide, was first isolated from the sea hare Dolabella Auricularia by Pettit et al. Since its bioactivity lacks of information, target identification is the indispensable strategy to reveal the potential target and mechanism of action of Dolastatin 16. Network pharmacology was utilized to identify the target associated with the disease, gene ontology, and KEGG pathway. The results demonstrated Matrix Metalloproteinase-9 (MMP9) as a potential target of Dolastatin 16 via network pharmacology analysis. The target was also mainly involved in TNF signaling pathway and foot ulceration-associated diabetic polyneuropathy. Further, the binding mode and dynamic behavior of the complex was investigated by molecular docking and molecular dynamics studies. In docking study, a native ligand (a hydroxamate inhibitor) and (R)-ND-336 were used as the ligand controls, demonstrating the binding energies of -6.6 and − 8.9 kcal/mol, respectively. The Dolastatin 16 complex showed the lowest binding energy of -9.7 kcal/mol, suggesting its higher potential as an inhibitor. Molecular dynamics also validated the stability of MMP9-Dolastatin complex throughout the simulation process. Dolastatin 16 may act as a MMP9 inhibitor and have potential to accelerate the wound healing process in diabetic foot condition.
Macroeconomic impact of an international fishery regulation on a small island country
Authors: Guillotreau Patrice , Dissou Yazid , Antoine Sharif , Capello Manuela , Salladarré Frédéric , Tidd Alex , Dagorn Laurent 
Published: July 2023

Abstract
This paper examines the macroeconomic impact of a tuna fishing regulation on a small island economy that relies heavily on tourism and fishing for foreign exchange earnings. While there is scientific consensus to limit the use of drifting fish aggregating devices (dFADs) worldwide, there is no agreement on their optimal number at sea. Resolution 23/02, adopted by the Indian Ocean Tuna Commission (IOTC) in February 2023, proposes a 72-day moratorium on dFADs, but this resolution faces opposition from many contracting parties, particularly developing countries. To understand the reasons for this opposition, a recursive multi-sector dynamic general equilibrium model is developed for the Republic of Seychelles, a small tuna-dependent country. The model assesses the short- and medium-term macroeconomic impacts of a seasonal dFAD closure in the Indian Ocean tuna fishery. The analysis suggests that a 12% decline in canned tuna exports would result in a -8.8% deviation from the trend in real Gross Domestic Product after seven years. Such an impact would have wide-ranging effects on the domestic economy, affecting all components of aggregate demand. Consequently, the economy would become more dependent on tourism, which has shown its vulnerability during the recent pandemic crisis. The study highlights the importance of considering social and economic aspects in sustainable fisheries management and provides insights into the potential consequences of dFAD regulations for small island economies.
JEL codes: Q22, D68, E65
Are public sector workers in Ghana overpaid? Evidence from a Blinder-Oaxaca decomposition analysis.
Authors: Kaba Jeffrey 
Published: July 2023

Abstract
This paper employs the Blinder-Oaxaca decomposition method to estimate the private-public sector wage gap, investigating the public sector wage premium using an analytical sample of 876 wage workers. These workers were drawn from a nationally representative household dataset - the seventh round of the Ghana Living Standards Survey (GLSS 7) data. The results suggest that private sector workers, including those in the informal sector, earn lower wages than their counterparts possessing the same level of human capital in the public sector. Returns to education in the public sector surpass those in the private sector, particularly for the less educated. However, the wage gap becomes statistically insignificant when observed among formal private sector workers and formal public sector wage workers, a consistency with public sector wage compression. These findings contribute to the ongoing debate about private-public wage differentials by introducing context-specific insights from Ghana, particularly when comparing the wages of formal private and public workers. Although the results challenge the common belief that private sector workers receive significantly less premium than public sector workers, this paper underlines the importance of formalizing the predominantly informal private sector as a policy measure to reduce the private-public wage gap.
JEL classifications J24, J31, J45, J46
Ethnobotanical and biochemical features of Sesbania sesban L. Merr., a nitrogen-fixing plant native to the Republic of Chad
Authors: Mahamat Ousman Brahim , Younes Saoud , Otchom Boy Brahim , Franzel Steven , Hidjazi Al-Djazouli Ouchar Mahamat , Soumaya El Ismaili 
Published: July 2023

Abstract
This study reports on a literature review of the leguminous tree Sesbania sesban (L.) Merr, which is found in the N'Djamena region, the Republic of Chad. The study focused on S. sesban’s phytochemical features and its use as a medicine and fodder to assist in future evaluations. A literature review using international academic websites, such as Science Direct, Springer, Nature, plant databases, and data from national herbaria was done. S. sesban is a perennial shrub or tree that measures 3–4 meters in height. This species is becoming rare in Ndjamena but can be found in some gardens of some institutions in Ndjamena such as the Higher Institute of Educational Sciences (ISSED). The local inhabitants in Chad use the species as medicine, livestock feed, fuel-wood, and for improving soil fertility and repelling desert encroachment. Traditional healers use its leaves to treat breast cancer and edema. S. sesban is an essential species native to the Republic of Chad that needs conservation and valorization. Viewing its rarity in N’Djamena today, a strategy of replanting the species in gardens, homes, and fields around Ndjamena and other regions of Chad is recommended.
Wealth, Poverty and Gnostics (Part I)
Authors: Пантелеев А.Д. 
Published: July 2023

Во II–III вв. существовала группа гностических течений, считавших демиурга, бога-творца низшего материального мира, не добрым или злым, а справедливым. Это валентиниане Гераклеон и Птолемей, сын и ученик гностика Карпократа Епифан, авторы сочинений «Трехчастный трактат», «Ипостась архонтов» или «О происхождении мира» из собрания Наг-Хаммади. Эти гностики утверждали, что он заботится о духовных людях – пневматиках, имеющих в своей душе частицу света. Они ощущали себя частью не только высшего, духовного мира, но и в какой-то мере этого, материального, и были нацелены на позитивное взаимодействие с римскими властями и языческим обществом в большей степени, чем церковные христиане. Взгляд на демиурга как защитника и покровителя позволял решить многие вопросы, в том числе проблему отношения к земному богатству. Демиург заботился о душах, имевших в себе духовное зерно, он или помещал их в тех, кто родился в знатных и богатых семьях, или возвышал и обогащал этих пневматиков. Богатство, таким образом, не стигматизировалось, а превращалось в знак избранности и элитарности.
In the 2nd–3d centuries there was a group of Gnostic movements that considered the Demiurge — the creator of the lower material world — neither good no evil, but just. They claimed that he cares about pneumatics, who have a part of higher light in their soul. We can remember the Valentinians Heracleon and Ptolemaeus, the son and disciple of Carpocrates Epiphanes, the authors of the "Three-part Treatise", "Hypostasis of the Archons" or "On the Origin of the World" from the Nag Hammadi Library. These Gnostics felt themselves as a part not only of the higher, spiritual world, but also to some extent of this, material, and they were aimed at positive interaction with it. The view of the Demiurge as a protector and patron allowed to solve many issues, including the problem of attitude to earthly wealth. The Demiurge took care of the souls who had a spiritual seed, he placed them in noble and rich families, and elevated and enriched these pneumatics. Wealth was not stigmatized by them but turned into a sign of being chosen and elitism.
Intellectuals of Piedmont in the Time of Napoleon: Between Ideological Loyalism and Forced Adaptation
Authors: Митрофанов А.А. 
Published: July 2023

В статье на примерах биографий пьемонтских политиков и интеллектуалов Просперо Бальбо, Карло Ботты, Гаспаре Морардо и Карло Босси рассматривается воплощение наполеоновской политики «амальгамы» в Пьемонте начала XIX в. Идея соединения и селекции элит относится к числу главных в интеграционном проекте Наполеона Бонапарта. В основу этой политики был положен принцип лояльности новому режиму. Как мы видим на конкретных примерах рубежа XVIII–XIX вв., лояльность могла быть выражена разными способами и требовала адаптации к новым социальным и политическим обстоятельствам, принятия новых правил. Принцип лояльности, однако, был совмещен с принципом персональной значимости того или иного функционера. Очень многое в процессе распределения новых статусов зависело только от самого Наполеона. Труднее всего приходилось тем, кто прочно связал свою карьеру с республиканским режимом 1799 г. Неудачный в целом опыт республиканских правительств в Пьемонте давал основания французской администрации удалять таких деятелей из политической жизни этого региона и заменять их на тех, кто отличался умеренностью взглядов и большей гибкостью. Наибольшей способностью адаптироваться обладали такие опытные люди как Бальбо, для которых сфера управления и в новых имперских условиях была родной стихией.
In this article, using specific examples of the biographies of Piedmontese politicians and intellectuals - Prospero Balbo, Carlo Botta, Gaspare Morardo and Carlo Bossi, the author analyzes the implementation of the Napoleonic policy of «amalgam» in Piedmont at the beginning of the 19th century. The idea of ​​uniting and selecting elites is one of the main ones in the integration policy of Napoleon Bonaparte. This policy was based on the principle of loyalty to the new regime. As we can see from specific examples of the turn of the 18th-19th centuries, loyalty could be expressed in different ways and required adaptation to new social and political circumstances, the adoption of new rules. The principle of loyalty, however, was combined with the principle of the personal importance of this or that functionary. A lot of things in the process of distribution of new statuses depended only on Napoleon himself. It was hardest of all for those who firmly linked their careers with the republican regime of 1799. The generally unsuccessful experience of the republican governments in Piedmont gave reason to the French administration to remove such figures from the political life of this region and replace them with those who were distinguished by moderation of views and greater flexibility. Experienced people like Balbo had the greatest ability to adapt, for whom the sphere of government was their native element even in the new imperial conditions.
Russia and Great Britain: The National Factor in the Competition of the Great Powers
Authors: Демешко Н.Э. , Ирхин А.А. 
Published: July 2023

В статье раскрываются модели этнонациональной политики России и Великобритании, а также технологии актуализации и использования национального фактора в российско-британской конкуренции XIX–XXI вв. Авторы рассматривают национальный вопрос как один из инструментов противостояния великих держав, поскольку язык, религия, «зов крови», конструирование национальных мифов о «золотом веке» и идентификация врага, лишившего нацию былого величия, порождают раздвоенность элит малых народов, ориентирующихся на противоборствующие геополитические центры в борьбе за власть и ресурсы внутри национальных общин.
The article reveals the models of the ethnonational policy of Russia and Great Britain, as well as the technologies of actualization and playing out the national factor in Russian-British relations of the XIX–XXI centuries. The authors consider the national question as one of the instruments of competition of the great powers. Since language, religion, the "call of blood", the construction of national myths about the "golden age" and the identification of the enemy who deprived the nation of its former greatness, give rise to a split of the elites of small nations, focusing on opposing geopolitical centers in the struggle for power and resources within national communities.
Practices of reforming the political sphere of Russian society in the early XX century in the perception of contemporaries
Authors: Селунская Н.Б. 
Published: July 2023

В статье предпринята реконструкция многообразного восприятия практик по реформированию политической сферы Российской империи начала ХХ в., сохраненного в памяти современников, наблюдателей от правительственной власти, инсайдеров процесса обновления институтов власти, депутатов народного представительства, писателей и журналистов, авторов брошюр, рефлексирующих над событиями «российской весны». Применение методологии “memory studies”, а также дискурсивного анализа к текстам эго-документов позволило реконструировать эмоциональные и противоречивые оценки современниками влияния на процессы обновления российского общества «исторических традиций», в том числе, почтенной традиции бюрократического самовластия, которая «тяготеет над русским народом целые века, ей мы обязаны целым рядом экспериментов над нашим государственным организмом», пагубно влиявшая на трансфер и адаптацию на российской почве «свобод», культуры выбора. Другим значимым ракурсом восприятия современниками трансформаций, связанных с появлением института народного представительства, является их видение роли разных типов конфликтов «власти» и «общества», как, например, неудачный опыт взаимодействия «власти с неостывшей обидой побежденного и народных представителей с злорадным торжеством победителей» которые стали причиной «стремительного драматического конца российского парламента».
The article attempts to reconstruct the diverse perception of the practices of reforming the political sphere of the Russian Empire at the beginning of the 20th century, preserved in the memory of contemporaries, observers from government authorities, insiders of the process of updating government institutions, deputies of the people's representation, writers and journalists, authors of brochures reflecting on the events of the “Russian spring”. The application of the “memory studies” methodology, as well as discursive analysis to the texts of ego-documents, made it possible to reconstruct the emotional and contradictory assessments by contemporaries of the influence of “historical traditions” on the processes of renewal of Russian society, including the venerable tradition of bureaucratic autocracy, which “gravitates over the Russian people for centuries, we owe it a whole series of experiments on our state organism”, which had a detrimental effect on the transfer and adaptation on Russian soil of “freedoms”, a culture of choice. Another significant perspective of the perception by contemporaries of the transformations associated with the emergence of the institution of popular representation is their vision of the role of different types of conflicts between “authority” and “society”, such as the unsuccessful experience of interaction between “authority with the unrelenting resentment of the defeated and people’s representatives with malicious triumph winners" which caused "the rapid dramatic end of the Russian parliament".
“You Will Quickly Find Tynda on the Map…”: Late Soviet School Local Studies and Images of the City in Educational Literature
Authors: Степанов Б.Е. 
Published: July 2023

В центре исследования находится вопрос о роли школьного краеведения в формировании городского воображения в позднесоветском обществе. Одним из результатов возрождения краеведения в послевоенный период стало появление корпуса учебных пособий, призванных содействовать знакомству учащихся с местной природой и историей. Изучая изданные в 1960–1980-х гг. региональные учебники для 3–4-го класса в связи с вопросом репрезентации в них города, автор делает выводы о специфике развития школьного краеведения и, в частности, по сравнению с предшествующими и последующими периодами его развития.
The paper focuses on the role of school local studies (kraevedenie) in shaping the urban imagination in late Soviet society. One of the results of the revival of local studies in the post-war period was the emergence of a corpus of textbooks designed to supplement students' knowledge of local nature and history. Having selected the corpus of history and natural history textbooks for 3rd-4th grades, published in the 1960s-1980s by regional publishers, as the source material for the study, the author draws conclusions on the specific development of school local studies and, in particular, the representation of the city in them compared with previous and subsequent periods of its development.
ДВЕ ВСТРЕЧИ РУССКИХ ПОСЛОВ С ДАВИДОМ ХИТРЕУСОМ
Authors: Местковский Д.Д. 
Published: July 2023

В предпринята попытка проследить изменения во взглядах немецких протестантов на православие в конце 1570-х – начале 1580-х гг., которые хорошо проявились в двух разных описаниях одного и того же события (воспоминания и впечатления от личной встречи с русскими послами) в письмах Давида Хитреуса. Делается вывод о том, что общее разочарование ходом переписки тюбингенских теологов с патриархом Иеремией II заставило Хитреуса более трезво подойти к вопросу о доктринальном сходстве православия и протестантизма.
This article attempts to trace the changes in Protestants’ views on Orthodoxy in the late 1570’s and early 1580’s. These changes are well observable in two accounts of the same event (impressions from personal meetings with Russian ambassadors) in the letters of D. Chytraeus. It is concluded that the general disappointment with the course of correspondence between the Tübingen theologians and Patriarch Jeremiah II compelled D. Chytraeus to describe similarities between Orthodoxy and Protestantism more circumstantially.
L.D. Trotsky and the 1922 Campaign to Seize Church Property (On the 100th Anniversary of the Seizure of Church Property)
Authors: Володько А.В. 
Published: July 2023

В 2022 г. исполнилось 100 лет одному из трагических событий в истории России – кампании по изъятию церковных ценностей, организованной большевистским правительством под предлогом помощи голодающим с целью пополнения государст-венной казны и смены власти в Русской православной церкви. В статье представлен анализ основных этапов деятельности Л.Д. Троцкого, одного из главных идеологов и организаторов этой кампании. При подготовке статьи были использованы материалы Российского государственного архива социально-политической истории, Государственного архива Российской Федерации и документы, опубликованные в сборниках «Архивы Кремля. Политбюро и церковь», «Русская православная церковь и коммунистическое государство 1917–1941» и др.
The year 2022 marks the 100th anniversary of one of the tragic events in Russian history - the campaign to seize church treasures, organised by the Bolshevik government under the pretext of helping the starving to replenish the state treasury and change the power in the Russian Orthodox Church. The article presents an analysis of the main stages of the activity of L. D. Trotsky, one of the main ideologists and organizers of this campaign. In preparing the article the archival materials of the Russian State Archive of Social and Political History, the State Archive of the Russian Federation, as well as documents published in the collections "The Kremlin Archives. Politburo and Church", "The Russian Orthodox Church and the Communist State 1917-1941" and others.
Management of A Case of Fibro-epithelial Hyperplasia of Gingiva
Authors: Pati Ritam Chandra , Agarwal Swati , Farheen  , Thakuria Anurag 
Published: July 2023

ABSTRACT:
Fibroepithelial hyperplasia/fibroma is an exophytic growth which occurs due to any reactive or chronic inflammatory condition of the gingiva by plaque, calculus, overhanging margins, trauma and dental appliances. These can cause discomfort to the patient and often causes difficulty in oral hygiene maintenance. This case report presents a case of a fibro-epithelial hyperplasia in a 37 years old female, who presented with a localized diffuse type of gingival enlargement in the left maxillary posterior teeth region. Based on clinical and histopathological evaluation the diagnosis of fibro-epithelial hyperplasia was made. The patient was then kept on regular follow-up and no recurrence of the lesion could be appreciated till date.