bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in cross‐sector collaboration between nurse home visitors and community providers in the United States: A panel survey analysis
Authors: Williams Venice Ng , Franco‐Rowe Carol , Knudtson Michael , Tung Gregory , Allison Mandy 
Published: September 2023

AbstractObjectiveAssess changes in cross‐sector collaboration between Nurse‐Family Partnership (NFP) nurse home visitors and community providers in the United States.Data Sources and Study SettingWe collected primary data via internet‐based surveys of all NFP nursing supervisors in the United States in 2018, 2020, and 2021.Study DesignWe conducted a panel survey to measure changes in cross‐sector collaboration between NFP nurses and 10 provider types in healthcare and social services. We assessed relational coordination using the validated seven item Relational Coordination Scale and structural integration using four items adapted from the Interagency Collaboration Activities Scale. Responses over time were compared using one‐way analysis of variances (ANOVAs) and pairwiset‐tests. We used the Kruskal–Wallis rank test to assess differences in collaboration by implementing agency type.Data CollectionAll nursing supervisors from NFP implementing agencies in the United States were eligible for the study. Survey implementation was conducted using Qualtrics and administered to all eligible participants (N = 370 [2018], 383 [2020], 414 [2021]). Email reminders were sent every 7–10 days, followed by a final telephone outreach.Principal FindingsThe response rate was 71% in 2018, 83% in 2020, and 74% in 2021. Relational coordination scores were calculated as a mean of the seven items and ranged from 1 to 5 (not at all to completely); integration scores were calculated as a sum of the four items and ranged from 4 to 20, where higher scores indicated greater sharing of resources. Coordination with women's care increased from 2018 to 2020 (M = 3.39 vs. 3.57;p < 0.01); while coordination (M = 3.23 vs. 3.01;p < 0.05) and integration (M = 6.50 vs. 5.28 vs. 5.43;p < 0.01) with parenting programs decreased.ConclusionsChanges to cross‐sector collaboration varied by provider type, likely due to the delivery of NFP and other services via telehealth during the COVID‐19 pandemic. There is an opportunity to improve cross‐sector collaboration in home visiting to better address family needs.
Investigation of the absolute bioavailability, mass balance, metabolism, and excretion of the cholesterol 24‐hydroxylase inhibitor soticlestat in healthy volunteers
Authors: Yin Wei , Ballard T. Eric , Zhu Sean Xiaochun , Hsiao Samuel , Chen Hao , Li Yuexian , Chowdhury Swapan K. , Stevenson Annette , Hui Tom , Hunt Allen , Asgharnejad Mahnaz , Han Steve 
Published: September 2023

AbstractAimsOur aim was to determine the absolute bioavailability, mass balance, metabolism and excretion of soticlestat (TAK‐935).MethodsAn open‐label, two‐period, single‐site, phase 1 study was conducted in six healthy men. In Period 1, a single 300 mg dose of soticlestat was administered orally, followed by a 15‐min intravenous infusion of [14C]soticlestat 50 μg (~1 μCi) 10 min later. In Period 2, a single 300 mg dose (~100 μCi) of [14C]soticlestat in solution was administered orally. Samples were collected, analysed for radioactivity or unchanged soticlestat, and profiled for metabolites.ResultsIn Period 1, soticlestat had an absolute bioavailability of 12.6% (90% confidence interval, 7.81–20.23%). In Period 2, there was near‐complete recovery of total radioactivity (TRA) following a 300 mg dose of [14C]soticlestat: urine, 94.8% (standard deviation [SD], 1.35%); faeces, 2.7% (SD, 1.67%). Of TRA, 0.1% (SD, 0.09%) and 0.6% (SD, 0.21%) were recovered as soticlestat and metabolite M‐I in urine, respectively. In plasma, soticlestat and M‐I reached geometric mean maximum observed concentrations of 1352 ng/mL (geometric percent coefficient of variation [gCV%], 61.3) and 253.2 ng/mL (gCV%, 44.1) after 25 min and declined with mean terminal half‐lives (SD) of 5.7 (2.90) and 2.0 (0.15) h, respectively. Soticlestat represented 4.9% of TRA in plasma. Soticlestat was rapidly eliminated primarily via O‐glucuronidation to metabolite M3, which was the dominant species in plasma (92.6%) and urine (86%).ConclusionsThis study indicates that soticlestat and its metabolites are rapidly cleared and eliminated, lowering the risk of dose accumulation from repeated dosing and supporting further investigation of soticlestat.
A Robust Grid‐Based Meshing Algorithm for Embedding Self‐Intersecting Surfaces
Authors: Gagniere S. , Han Y. , Chen Y. , Hyde D. , Marquez‐Razon A. , Teran J. , Fedkiw R. 
Published: September 2023

AbstractThe creation of a volumetric mesh representing the interior of an input polygonal mesh is a common requirement in graphics and computational mechanics applications. Most mesh creation techniques assume that the input surface is not self‐intersecting. However, due to numerical and/or user error, input surfaces are commonly self‐intersecting to some degree. The removal of self‐intersection is a burdensome task that complicates workflow and generally slows down the process of creating simulation‐ready digital assets. We present a method for the creation of a volumetric embedding hexahedron mesh from a self‐intersecting input triangle mesh. Our method is designed for efficiency by minimizing use of computationally expensive exact/adaptive precision arithmetic. Although our approach allows for nearly no limit on the degree of self‐intersection in the input surface, our focus is on efficiency in the most common case: many minimal self‐intersections. The embedding hexahedron mesh is created from a uniform background grid and consists of hexahedron elements that are geometrical copies of grid cells. Multiple copies of a single grid cell are used to resolve regions of self‐intersection/overlap. Lastly, we develop a novel topology‐aware embedding mesh coarsening technique to allow for user‐specified mesh resolution as well as a topology‐aware tetrahedralization of the hexahedron mesh.
Characterization the prognosis role and effects of snoRNAs in melanoma patients
Authors: Wang Lei‐Yun , Song Jia‐Nan , Chen Yi‐Xuan , Zhu Ying , Ren Hui‐Li , Li Qiu‐Qi , Zhang Shao‐Hui 
Published: September 2023

AbstractMelanoma is a melanocyte‐derived malignant cancer and is known for its early metastasis and high mortality rates. It is a highly cutaneous tumour disease that could be related to the abnormal immune microenvironment, and the identification of reliable diagnostic and prognostic markers is crucial for improving patient outcomes. In the search for biomarkers, various types of RNAs have been discovered and recognized as reliable prognostic markers. Among these, small nucleolar RNAs (snoRNAs) have emerged as a promising avenue for studying early diagnosis and prognostic markers in tumours due to their widespread presence in tissues, tumour specificity and stability. In our study, we analysed snoRNAs data from melanoma samples in the TCGA‐SKCM cohort and developed a prognostic model comprising 12 snoRNAs (SNORD9, SNORA31, SNORD14E, SNORA14A, SNORA5A, SNORD83A, SNORA75, AL096855, AC007684, SNORD14A, SNORA65 and AC004839). This model exhibited unique prognostic accuracy and demonstrated a significant correlation with the immune infiltration tumour microenvironment. Additionally, analysis of the GSE213145 dataset, which explored the sensitivity and resistance of immune checkpoint inhibitors, further supported the potential of snoRNAs as prognostic markers for immunotherapy. Overall, our study contributes reliable prognostic and immune‐related biomarkers for melanoma patients. These findings can offer valuable insights for the future discovery of novel melanoma treatment strategies and hold promise for improving clinical outcomes in melanoma patients.
Global variation in the relationship between avian phylogenetic diversity and functional distance is driven by environmental context and constraints
Authors: Yaxley Keaghan J. , Skeels Alexander , Foley Robert A. 
Published: September 2023

AbstractAimIf evolutionary distance is akin to evolutionary chance, then it follows that species assemblages that are distantly related will also be more disparate in terms of their traits, features and the niches they occupy. Yet, studies have found that the total phylogenetic distance of an assemblage, known as phylogenetic diversity, is an unreliable surrogate for functional diversity. We investigate global variation in the relationship between Faith's phylogenetic diversity (PD) and mean pairwise functional distance (MPFD) across latitude and the influence of migratory species on both these aspects of diversity.LocationGlobal.Time periodPresent day.Major taxa studiedBirds.MethodsWe measure PD and MPFD for over 9000 species of bird across more than 17,000 globally distributed assemblages. We obtain standardised effect sizes for both indices by simulating assemblage composition under an ecologically informed null model. We employ path analysis to characterize variation in the relationship between PD's and MPFD across latitude, elevation and with proportion of migratory species.ResultsGlobally, assemblages that were phylogenetically diverse tended to be less functionally dispersed than expected; however, this relationship showed considerable variation across latitude decreasing with distance from the equator. The proportion of migratory species in an assemblage was found to be an important predictor of functional diversity, with migrant rich assemblages generally showing less functional diversity than expected. We identify the Andes and Hengduan Mountains as regions of exceptional bird functional diversity.Main conclusionsThe relationship between phylogenetic diversity and function diversity is context specific, varying across environmental gradients such as latitude, and influenced by ecological phenomena such as migration. Thus, care should be taken using phylogenetic diversity as a proxy for functional diversity, particularly in clades with sparse functional data. Instead, we recommend that studies consider how phylogenetic diversity's surrogacy for functional diversity may be impacted by environmental context and evaluate empirical observations against biogeographically constrained and ecologically informed null models.
BREAKING THE COGNITIVE DIMENSION OF LOCAL PATH DEPENDENCE: AN ENTREPRENEURIAL PERSPECTIVE
Authors: Fredin Sabrina 
Published: September 2023

ABSTRACTFew attempts have been made to consider the role of individual activities in path dependence. The purpose of this paper is to analyse how local entrepreneurial activities can lead to a break in the cognitive local path. The theoretical framework rests on the literature on path dependence, but focuses mainly on cognitive frames as carriers of path‐dependent behaviour. A qualitative case study has been used to analyse the formation and breaking of a local cognitive path through individual activities. Four main conclusions can be drawn. First, cognitive paradigms explain why the degree of adaptability differs between locations. Second, external shocks are translated to local change through individual activities. Third, acknowledging cognitive barriers to individual behaviour, the important role of outsiders is highlighted for breaking the cognitive path. Fourth, the long durability of cognitive paradigms and the importance of outsiders suggest the emergence of a parallel, alternative cognitive path.
The use and impact of European Testing Week regional awareness campaigns to increase HIV and viral hepatitis testing coverage
Authors: Raben Dorthe , Kahama C. B. , Combs L. , Stengaard Annemarie , Rockstroh J. K. , Simões Daniel , Collins Ben ,   the European Testing Week Working Group and the EuroTEST Steering Committee
Published: September 2023

AbstractIntroductionSince 2013, the European Testing Week (ETW) awareness campaign has become a key regional event influencing testing efforts for HIV, viral hepatitis, and sexually transmitted infections (STIs) through participation of 720 organizations. Here, we report on a survey from May to June 2022 aimed at assessing the participant‐reported impact of the campaign.MethodsAll past and current participating organizations were asked to complete an online questionnaire between 12 May and 17 June 2022. Multiple choice and open‐text questions included organization information, usage of ETW to engage in local testing‐related activities, and the effect of a regional campaign to reach a wider audience and generate impact.ResultsOf the 52 respondents, 34 (65%) stated first participating in ETW 5–10 years ago. ETW was used for awareness raising by 40 respondents (83%), new testing activities by 37 (77%), advocacy initiatives by 15 (31%), and training/capacity building by 18 (38%). For awareness raising, 95% used ETW to highlight the importance of and to encourage testing; for new testing activities, 74% used ETW to reach new groups. In total, 44 (85%) reported added benefits of a Europe‐wide campaign compared with national/local campaigns, particularly the increased visibility and collaboration opportunities. Impact at the local level was observed by 24 (51%), and impact at a national level was observed by 20 (43%). A total of 28 (79%) reported increases in the number of tests performed and 25 (75%) reported increases in clients accessing services.ConclusionsRegional awareness campaigns reach wider audiences, boost local and national efforts to increase testing, and sensitize key populations about the critical value of testing compared with local/national campaigns.
Home Political Connections and Outward FDI of Emerging Market Firms
Authors: Huang Yuanyuan , Zhou Kevin Zheng , Wu Zhan , Wang Jue 
Published: September 2023

AbstractWhile political connections are a critical non‐market strategy for emerging market firms (EMFs) to achieve success, how they affect EMFs’ outward foreign direct investment (OFDI) remains controversial. Building on the institution‐based view, we examine how home‐country political connections facilitate or impede EMFs’ OFDI. Using a panel dataset of listed private firms in China, we find that home political connections have an inverted U‐shaped effect on firms’ OFDI level; the effect becomes flatter as pro‐market reforms proceed in the home country, but becomes steeper for firms with strong technological capability. By revealing a nonlinear effect, our study helps reconcile inconsistencies regarding the role of home political connections in OFDI and has important implications for EMFs’ internationalization.
Telework in public organizations: A systematic review and research agenda
Authors: Mele Valentina , Belardinelli Paolo , Bellé Nicola 
Published: September 2023

AbstractAfter a relatively slow policy intervention and scholarly take‐up, recent developments created the urgency for massive efforts to implement and regulate telework in public organizations. We contribute to this debate through a systematic review of 120 studies across disciplines. Findings from our analysis reveal a few established antecedents of telework, including individual characteristics like family responsibilities and expected productivity, but also organizational aspects like supportive leadership, and contextual features like natural disasters. Self‐reported productivity and work‐life balance stand out as telework's most widely studied outcomes, although evidence is often conflicting when coming to the effects of telework. We present our results by distinguishing pre‐ and post‐pandemic findings. Complementing our systematic review, we engage in a generative exercise by identifying emerging debates on telework in public bureaucracies. We conclude by indicating future research directions.
Modes of network governance revisited: Assessing their prevalence, promises, and limitations in the literature
Authors: van den Oord Steven , Kenis Patrick , Raab Jörg , Cambré Bart 
Published: September 2023

AbstractThe systematic literature review takes stock of the empirical literature on the governance of organizational networks. The analysis is based on empirical papers citing Provan and Kenis (2008) as the seminal article on the governance of networks. We synthesize key findings on the modes of network governance, contingency factors, and network‐level tensions. The review provides insights into how the contingency theory of network governance has developed into an established and recognized research agenda in the last 15 years. We conclude that the governance of organizational networks as a vocabulary has been adopted in the management and organization sciences literature to explain organizational networks' development, functioning, and effectiveness. However, further theoretical development and testing are warranted to inform the practice of network governance, particularly when, how, and why to use institutions and structures of authority and collaboration to allocate resources and coordinate and control joint action of groups of organizations.
Impact of financial inclusion on household welfare in Liberia: A gendered perspective
Authors: Mulbah Francis F. B. , Olumeh Dennis Etemesi , Mantey Vida , Ipara Billy Okemer 
Published: September 2023

AbstractFinancial inclusion (FI) is critical to achieving the Sustainable Development Goals, particularly zero poverty, gender equality, and reduced inequalities, but there is limited evidence of its impacts on household welfare in fragile and post‐conflict countries (FPCCs). This study analyses the impact of FI on household welfare in Liberia using the Liberian Household Income and Expenditure Survey of 2016–2017. For the empirical analysis, we use an inverse probability‐weighted regression adjustment model and separate analyses for male‐headed households (MHHs) and female‐headed households (FHHs) to identify possible gender differences. We find that using mobile money statistically significantly increases household food security for MHHs and FHHs. In particular, the welfare impact is greater for MHHs in terms of food availability, while in relation to food quality and dietary diversity, the impact is greater for FHHs. These findings show the need to scale up FI in FPCCs as a catalyst for improving household welfare.
Ignition of Various Lubricating Oil Compositions Using a Shock Tube
Authors: Abulail Matthew , Cooper Sean P. , Sandberg Matthew G. , Petersen Eric L. 
Published: September 2023

Abstract
With new restrictions imposed on gas turbine efficiencies and power outputs, lubricating oils are used at higher temperatures and harsher conditions leading to potential, unintended combustion. To establish an understanding of lubricating oil's resistance to combustion, a new spray injector system was utilized in the High-Pressure Shock Tube (HPST) Facility at the TEES Turbomachinery Laboratory at Texas A&M University. Two gas turbine oils (Mobil DTE 732 and Castrol Perfecto X32), a base mineral oil, and a surrogate (n-hexadecane) were tested at postreflected shock conditions at equivalence ratios near 2.5. Castrol Perfecto X32 was also characterized at an equivalence ratio near 1.2. All of the lubricating oils displayed ignition between temperatures of 1152 and 1383 K and near atmospheric pressures. To characterize combustion, two different definitions of ignition delay time (IDT) were considered: sidewall OH* chemiluminescence and sidewall pressure. Both definitions were used to create temperature-dependent correlations for each of the lubricating oils. In general, both definitions provided similar results within the accuracy of the measurements. One trend from the data herein is that the brand-name oils (Mobil DTE 732 and Castrol Perfecto X32) provided ignition delay times that were similar to each other but slightly larger than the corresponding mineral oil and n-hexadecane results. This difference could be attributed to the additives that are present in the brand-name oils.
Antisense inhibition of RNA polymerase α subunit of
Clostridioides difficile
Authors: Pal Rusha , Seleem Mohamed N. 
Published: September 2023

ABSTRACT

Clostridioides difficile,
the causative agent of antibiotic-associated diarrhea and pseudomembranous colitis, has emerged as a major enteric pathogen in recent years. Antibiotic treatment perturbs the gut microbiome homeostasis, which facilitates the colonization and proliferation of the pathogen in the host intestine. Paradoxically, the clinical repertoire for
C. difficile
infection includes the antibiotics vancomycin and/or fidaxomicin. The current therapies do not address the perturbed gut microbiome, which supports the recurrence of infection after cessation of antibiotic therapy. Peptide nucleic acids (PNAs) are novel alternatives to traditional antimicrobial therapy capable of forming strong and stable complexes with RNA and DNA, thus permitting targeted inhibition of specific genes. Here, we report a novel PNA that can target the RNA polymerase α subunit (
rpoA
) in
C. difficile
. The designed anti-
rpoA
construct inhibited clinical isolates of
C. difficile
(minimum inhibitory concentration values ranged between 4 and 8 µM) and exhibited bactericidal activity. Furthermore, silencing of the
rpoA
gene suppressed the expression of genes that encode virulence factors [toxin A (
tcdA
), toxin B (
tcdB
)] in
C. difficile
, and the gene that encodes the transcription factor stage 0 sporulation protein (
spoOA
). Interestingly, the efficacy of the designed PNA conjugate remained unaffected even when tested at different pH levels and against a high inoculum of the pathogen. The
rpoA
-TAT conjugate was very specific against
C. difficile
and did not inhibit members of the beneficial gut microflora. Taken altogether, our study confirms that the
rpoA
gene can be a promising narrow-spectrum therapeutic target to curb
C. difficile
infection.

IMPORTANCE

The widespread use of antibiotics can destroy beneficial intestinal microflora, opening the door for spores of
Clostridioides difficile
to run rampant in the digestive system, causing life-threatening diarrhea. Alternative approaches to target this deadly pathogen are urgently needed. We utilized targeted therapeutics called peptide nucleic acids (PNAs) to inhibit gene expression in
C. difficile
. Inhibition of the RNA polymerase α subunit gene (
rpo
A) by PNA was found to be lethal for
C. difficile
and could also disarm its virulence factors. Additionally, antisense inhibition of the
C. difficile rpo
A gene did not impact healthy microflora. We also propose a novel approach to manipulate gene expression in
C. difficile
without the need for established genetic tools.
Distinguishing the Formation of Typhoon Forerunner Waves Propagating over the East China Sea and the Sea of Japan
Authors: Dolgikh G. I. , Budrin S. S. , Shvets V. A. , Yakovenko S. V. 
Published: September 2023

Abstract
During the propagation of the Hinnamnor typhoon from September 5 to 6, 2022, swell waves were recorded that arrived at the recording point 20 h before the typhoon entered the Sea of Japan. While analyzing the field data of the laser meter of fluid pressure variation, it was possible to calculate the area of the formation of the main group of swell waves generated by the propagating typhoon and to localize the region of generation of forerunner waves and also to describe the mechanisms of their formation and propagation.