bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calculation of upper support shafts cooling system parameters by means of the finite element method
Authors: Fedoriachenko Serhii , Ziborov Kyrylo , Dzhur Roman , Kholodov Anton 
Published: December 2022

Problem. The paper proposes a method for solving the problem of the temperature regimes of the upper support shafts using the finite element method. Thus, using the experimentally obtained values of the cooling air flow of the shafts, the possibility of using the State Thermal module of the Ansys software for a multi-iteration study of the temperature distribution and determining the ranges of thermal expansion was considered. It is an important task during engineering tasks solution. Goal. The goal of the paper is to develop a methodology to solve thermal exchange tasks using FEA methods based on the experiment research of the thermal processes. Methodology. Solution of the tasks involved application of the theoretical approach in order to build up multi-purpose solid models with the range of initial data to provide a simulation research. Results. The proposed method allows to determine the efficiency of the cooling system in a wide range of changes in air flow parameters and the compliance of the established thermal clearances of the bearing assemblies. Originality. Engineering tasks of the denoted area are rarely solved with FEA, especially thermal package. Thus, implementation of the software with experimental research kit allows in timely manner check the thermal state of the shafts and indicate possible cooling air leaks at the very first stage to avoid time consuming technical service. Practical value. The use of the denoted methodology allows to adjust cooling system in terms of sufficient shaft thermal state of bearing clearances and keep updated cooling parameters to maneuver the main ventilation system.
Chin augmentation with custom-made implants for microgenia treatment: a two-year follow-up
Authors: Donets I. G. , Panchuk O. V. , Galperin K. V. 
Published: December 2022

Objective — to determine the feasibility and effectiveness of using custom‑made and 3D‑printed mandibular implants in patients with microgenia, and to investigate their quality of life and satisfaction with aesthetic results during a two‑year follow‑up.
Materials and methods. 21 patients participated in the study, with 14 (66.7 %) women and 7 (33.3 %) men. The average age of patients was 23.4 ± 2.3 years. All patients had signs of microgenia. In our study, a CT scan of the skull without contrast enhancement served as the primary diagnostic tool. Polyetheretherketonen (PEEK) was the material of choice for the implants.
Results. Among the early postoperative complications were alterations to the sensation of the skin overlying the lower lip, which was restored within 1 — 2 months, and bruising, which had a tendency to spread to the neck. None of the patients had impaired motor innervation of the lower lip. Hematoma and wound suppuration were not detected either. One or two years after surgery, none of the patients had any delayed complications, including implant displacement, bone resorption in the lower jaw, decreased motor activity of the facial muscles, or altered sensation affecting the lower lip. Aesthetic results were assessed after the one‑year follow‑up. In a sample of 21 patients, the aesthetic outcome was excellent in 18 (85.7 %) patients and good in 3 (14.3 %) patients. No patients had bad aesthetic outcomes.
Conclusions. The absence of delayed complications and the low risk of early complications, which in 71.4 % of patients only present as a temporary alteration to the sensation affecting the lower lip, indicate the safety of the suggested method. In all patients after mentoplasty with custom‑made implants, the physical and mental components of health improved statistically (with all values p < 0.05). Excellent aesthetic outcomes were observed in almost all patients (85.7 %) after mentoplasty with custom‑made implants.
Anatomy-based treatment strategy for abdominal and retroperitoneal cystic lymphatic malformations in children
Authors: Diehtiarova D. S. 
Published: December 2022

Lymphatic malformations (LMs) are rare congenital benign malformations of the lymphatic system, consisting of fluid‑filled cysts or channels with unusual growth. The low incidence of LMs leads to a challenging differential diagnosis and a complicated choice of further treatment strategies. In this study, we analyzed our experience in the treatment of abdominal and retroperitoneal cystic LMs and proposed an anatomy‑based treatment strategy that could improve the treatment outcomes.
Objective — to prove that the anatomical localization of LM influences treatment effectiveness and should be taken into account when making treatment decisions.
Materials and methods. Out of 240 pediatric patients who underwent treatment for cystic LMs at a single center from December 2012 to December 2020, 43 (19.1 %) were diagnosed with abdominal and retroperitoneal LMs. The follow‑up period was 3.50 ± 2.16 years.
Results. Surgical resection of abdominal LMs without evident connection with cisterna chyli does not lead to a recurrence. Sclerotherapy is the best treatment option for retroperitoneal LMs. Diffuse mesentery affection can be successfully treated by sirolimus systemic therapy. According to a logistic regression model, initial choice of LM treatment without considering anatomical localization influences the risks of LM treatment failure (p = 0.000503). All patients in our study group received the following treatments: laparoscopic resections (n = 10, 23.2 %), videoassisted resections (n = 11, 25.5 %), laparotomy resections (n = 9, 20.9 %), sclerotherapy (n = 4, 9.3 %), sclerotherapy and surgery combination (n = 1, 2.3 %), sirolimus systemic therapy (n = 2, 4.6 %), and splenectomy (n = 1, 2.3 %). Six (13.4 %) patients are under dynamic observation. The recommended technique for treating abdominal LMs produced excellent outcomes in 35 (81.4 %) patients, good outcomes in 5 (11.6 %) patients, satisfactory outcomes in 2 (4.7 %) patients, and unsatisfactory outcomes in 1 (2.3 %) patient.
Conclusions. Treatment strategies for abdominal and retroperitoneal LMs should be based on their anatomical localization. Retroperitoneal localization indicates a high risk of surgical treatment failure (p = 0.0006).
The improvement of treatment and prevention of non-alcoholic fatty liver disease progression against the background of metabolic disorders
Authors: Fadieienko G. D. , Gridnyev O. E. , Kushnir I. E. , Chernova V. M. , Solomentseva T. A. , Nikiforova Y. V. , Kurinna O. G. 
Published: December 2022

Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, with pathogenetic mechanisms involving complex factors, in particular changes in the intestinal microbiota. The development and evaluation of the effectiveness of NAFLD treatment regimens, affecting intestinal microbiota disturbances, presents an urgent issue in modern medicine.
Objective — to determine effects of combined therapy, including ursodeoxycholic acid (UDCA) and probiotic preparation (strains of Lactobacillus acidophilus, L. rhamnosus, Streptococcus salivarius subsp. thermophilus, L. delbrueckii subsp. Bulgaricus) on the metabolic disorders and inflammatory processes in liver tissue of patients with NAFLD.
Materials and methods. The study included 108 patients with NAFLD with metabolic disorders and 30 people of the control group, who were examined on the basis of the Department of Gastroenterology and Therapy and outpatient department of the GI «L. T. Mala National Institute of Therapy of the NAMS of Ukraine». Women prevailed in both groups. The mean age of patients was 54.6 ± 11.7 years. The patients were randomized into two groups, comparable by gender and age ratio. Both groups received non‑drug therapy. The comparison group (48 patients) received UDCA preparation only, the main group (60 patients) received additional probiotic preparation «Yogurt capsules» (Pharmascience Inc., Canada). The treatment lasted 12 weeks. Patients were examined at the beginning and end of treatment with additional determination of pro‑inflammatory markers: C‑reactive protein CRP and TNF‑α. Statistical analysis was performed with the package Statistica 13.1 using nonparametric methods.
Results. Patients’ examination in the dynamics of treatment showed an improvement in NAFLD course due to a decrease in the levels of alanine aminotransferase, aspartate aminotransferase and γ‑glutamyl peptidase (ALT, AST and GGT) in both groups. Moreover, against the background of treatment, the tendency was observed to the decrease of visceral fat percentage, as well as the visceral obesity index, which in group I significantly decreased in almost 1.6 times. In contrast to the carbohydrate metabolism indicators, the dynamics of which did not differ significantly between the groups, a significant effect of the developed therapy on the lipid profile was determined. The triglycerides (TG) levels in the main group decreased 1.3 times, and LDL cholesterol 1.6 times. In addition, the significant decrease in TNF‑alpha levels by 57.51 % was observed under the influence of treatment with the addition of probiotic yogurt.
Conclusions. Combined therapy which includes lifestyle modification by means of non‑drug therapy, UDCA with the additional use of a complex probiotic preparation yogurt capsules, has a pathogenetic focus and proven effectiveness in the treatment of NAFLD.
Management of patients with chronic abdominal pain due to disorders of gut-brain interaction. Review
Authors: Tkach S. M. , Dorofeev A. E. 
Published: December 2022

Disorders of gut‑brain interaction (DGBI), including irritable bowel syndrome (IBS), functional dyspepsia (FD), and centrally‑mediated abdominal pain (CMAP), are present in more than 40 % of the worldwide population. At the first stages, most of the DGBI patients receive treatment with therapeutic agents aimed at visceral stimuli, such as eating and bowel movements. Unfortunately, a large subset of DGBI patients continue to experience chronic abdominal pain, which adversely affects health‑related quality of life and often leads to excessive unwarranted diagnosis and treatment, including surgery. Management of patients with abdominal pain who do not respond to first‑line therapy for visceral stimuli is complex and involves exposure to a number of cognitive, affective, and behavioral factors, including education, pain expectations, and other psychosocial modifiers such as mood disorders and anxiety disorders. Effective treatment of pain requires establishing a trusting relationship between the patient and the physician and avoiding medications that patients may abuse, such as opioids. Management options include both non‑pharmacological methods and pharmacological therapy. The paper presents an updated clinical review prepared by experts from the American Gastroenterological Association, focusing on the management of patients with DGBI in whom pain does not decrease under the influence of first‑line therapy aimed at visceral stimuli. This review is presented in the form of best clinical advice, although it does not discuss the use of additional non‑traditional or alternative therapies, such as marijuana, and does not cover the treatment of abdominal wall or pelvic pain syndromes.
Pathogenetic role of fetuin-A in formation of metabolic disorders and systemic inflammation in patients with non-alcoholic fatty liver disease
Authors: Fadieienko G. D. , Kushnir I. E. , Chernova V. M. , Solomentseva T. A. , Nikiforova Y. V. , Kurinna O. G. 
Published: December 2022

Non‑alcoholic fatty liver disease (NAFLD) remains the leading nosology among hepatic diseases around the world. Its complex pathogenesis is not still clearly understood. Besides metabolic changes one of potential mechanisms of NAFLD development is changes in hepatokines, fetuin‑A in particular, secretion and metabolism.
Objective — to determine the role of fetuin‑A in the development and progression of NAFLD.
Materials and methods. The study enrolled 78 NAFLD patients with metabolic disorders and 30 volunteers as a control group. Additionally to routine examination serum concentration of fetuin‑A was determined. Statistical processing was carried out using SPSS 21.
Results. The results showed a statistically significant increase in fetuin‑A concentrations in NAFLD patients with concomitant MS (p < 0.05). There was a direct correlation between fetuin‑A levels and parameters of abdominal (WC and WHR, p < 0.05) and visceral obesity (VAT %, p < 0.05). Concentrations of fetuin‑A were higher in polymorbid patients, especially in the combination of NAFLD with type 2 diabetes mellitus and obesity. Fetuin‑A levels was associated with changes in carbohydrates and lipids parameters. Fetuin‑A positively correlated with glycated hemoglobin (r = 0.32, p < 0.05) and index HOMA (r = 0.36, p < 0.05). There was a positive correlation between fetuin‑A level and TG (r = 0.44, p < 0.05) and LDL cholesterol (r = 0.37, p < 0.05). Furthermore, an increase in fetuin‑A was associated with an increase in activity of ALT (r = 0.39, p < 0.05) and elevation of the level of TNF‑a (r = 0.33, p < 0.05). NAFLD patients with advanced stages of steatosis and fibrosis also demonstrated higher levels of fetuin‑A (p < 0.05).
Conclusions. The obtained data indicate a significant pathogenetic role of fetuin‑A in the development and progression of NAFLD.
Clinical-instrumental parameters, NT-proBNP level and indicators of quality of life in patients with heart failure and moderately reduced left ventricular ejection fraction depending on the presence of type 2 diabetes mellitus
Authors: Rudyk I. S. , Babichev D. P. , Medentseva O. O. , Gasanov I. C. , Chenchyk T. O. 
Published: December 2022

The aim: to evaluate effects of type 2 diabetes mellitus (DM 2) on the quality of life, clinical, biochemical and ultrasonographic parameters in patients with heart failure and moderately reduced left ventricular ejection fraction (HFwmrLVEF).
Materials and methods. The study involved 68 patients with HFwmrLVEF, including 36 patients with concomitant DM 2 and 32 patients without DM 2, and 18 healthy individuals. All study participants underwent anthropometric (height, weight, BMI), laboratory (clinical blood test, biochemical blood test to determine ACT, ALT, creatinine, glucose, lipid spectrum, potassium, sodium and magnesium, ELISA to determine glycated hemoglobin and NT‑proBN), instrumental (EchoC, ECG) surveys and surveys to assess quality of life (EQ‑5D‑5L). Statistical processing of the obtained results was performed using the statistical software package SPSS v.19.0.
Results. It has been established that patients with HFwmrLVEF and concomitant DM 2 in comparison with the subjects without DM 2 had significantly worser indices of carbohydrate metabolism, higher mean serum levels of NT‑proBNP, higher LV myocardial mass (LVMM) and LVMM index (іLVMM) based on the results of transthoracic Echo; they had worser quality of life as per the EQ­5D­5L results with absence of significant difference between the groups in the age and LV ejection fraction. The stronger correlation between NT­proBNР levels and іLVMM was established in patients without DM2, and absence of correlation between NT­proBNР levels and LVMM in subjects with the concomitant DM2, that may be due to some effects of DM2 on the process of pro­BNP conversion.
Conclusions. Patients with HFwmrLVEF with concomitant type 2 DM compared to the subjects with HFwmrLVEF without type 2 DM had significantly worser carbohydrate metabolism, significantly higher mean serum NT‑proBNP levels, higher LVMM and iLVMM as per the results of transthoracic EchoC, worser quality of life according to the results of the EQ‑5D‑5L questionnaire in the absence of a significant difference in age and LVEF between the groups. In addition, there was a stronger correlation between NT‑proBNP and iLVMM in patients without type 2 DM and no correlation between NT‑proBNP and LVMM in patients with concomitant type 2 DM, which may be due to certain influence of type 2 DM on the process of pro‑BNP conversion
The risk factors for the development of metabolic disorders in patients with arterial hypertension
Authors: Zhuravlyova L. V. , Pyvovarov O. V. 
Published: December 2022

The purpose of our study was to analyze the scientific publications containing the latest research data on the development of metabolic disorders in patients with arterial hypertension.
To systematize the data on risk factors for the development of metabolic disorders in patients with arterial hypertension, information in open databases such as PubMed, Scopus, Web of Science, Google Scholar and other materials of Ukrainian and foreign scientists have been analyzed. A review of the risk assessment of combined conditions in various countries worldwide has been performed. Control measures to prevent the development of complications in patients with a combination of hypertension and type 2 diabetes were considered. Emphasized the importance of early detection of metabolic disorders in patients with arterial hypertension, aimed at reducing the risk of complications. It has been established that significant prevalence of the combined course of arterial hypertension and type 2 diabetes necessitates the timely detection and correction of comorbid pathology.
Continuous monitoring of the presence of risk factors for metabolic disorders in patients with arterial hypertension in the general population helps to identify patients who need particular attention to achieve positive results of treatment and to prevent possible complications. Research in various countries gave evidence that type 2 diabetes prevalence and development of associated diseases make the greatest challenge to health care worldwide. The close correlation between the indicators of lipid and of carbohydrate metabolism has been confirmed, indicating the need for a complex pathogenetic approach to the treatment of patients with arterial hypertension. In recent years comorbidity had a significant economic and medico‑social impact for society, thus investigation of the factors of metabolic disorders development in patients with hypertension create the basis for the development of special methods for their prevention and treatment.
Hypoglycemia and cardiac arrhythmias in diabetes mellitus
Authors: Serik S. A. , Strona V. I. 
Published: December 2022

The article provides an assessment of cardiovascular risks associated with episodes of hypoglycemia in patients with diabetes mellitus. The analysis has been performed for the experimental and clinical data on cardiac arrhythmias during induced hypoglycemia in animal models and in patients with diabetes. The pathogenetic mechanisms of the development of life‑threatening heart rhythm disorders during hypoglycemic states (in particular, changes in autonomic nervous system activation and in the serum level of potassium) have been considered. The nature of electrocardiographic changes preceding the development of arrhythmias during hypoglycemia is described and factors affecting QT interval duration during hypoglycemia are given. The authors highlight the results of clinical studies of spontaneous hypoglycemia in terms of the arrhythmias’ specific features in daytime and nocturnal hypoglycemia, and different mechanisms of the cardiac arrhythmias’ development at different periods of the day. Clinical data have been presented as regards the drug‑induced hypoglycemia during administration beta‑adrenergic receptor blockers, angiotensin‑converting enzyme inhibitors, fluoroquinolones, as well as mechanisms of dysglycemic effects of these drugs. It has been noted that β‑blockers can mask symptoms of catecholamine‑mediated hypoglycemia. It has been established that among hypoglycemic agents, insulin secretion stimulators (sulfonylureas, meglinides) and insulin have the highest risk of serious hypoglycemia. However, the use of basal and prandial insulin analogues was associated with a lower frequency of hypoglycemia compared to human insulin. It was emphasized that hypoglycemia should be avoided in clinical practice to improve prognosis and prevent arrhythmias. For this, it is necessary to individualize target glycemic values with their mitigation in high‑risk patients, to use the safest insulin and non‑insulin hypoglycemic agents, and to implement new technologies (pumps, continuous glucose monitoring) more widely. It is extremely important to take into account comorbidity and the effects on hypoglycemia risk of drugs used for the treatment of concomitant diseases.
تحلیل ابعاد خلّاقيتِ شخصيت‏ پردازی رمان‏های غسان کنفانی بر اساس تئوری شخصیت مورگان فورستر
Authors: حسن اعظمی خويرد أ.م.د. , مسید محمد باقر حسینی د. , ماجد مرهج رباط أ.م.د 
Published: December 2022

شخصيت از عناصر کليدی روايت و پديد‏آورندة مدار داستان است و شيوة شخصيت پردازی، می‏تواند گواه خوبی برای خلاقيت يا تقليدپذيری صرف رمان نويس باشد . در همين راستا پژوهش حاضر می کوشد برخی الگوهای شخصيتی رمان‏هاي غسان کنفانی را با الهام گيری از الگوی مورگان فورستر مورد بررسی و تحليل قرار می‏دهد تا ابعاد خلاقيت شخصيت‏پردازی وی را نشان دهد. درالگوی فورستر هر اثر داستانی مشتمل برشخصيت پوپا(جامع)و ايستا(ساده)است و هر کدام كاركردی متفاوتی دارند. همچنين وي اشخاص ايستای داستان را بر مبناي ميزان توانايي آنها در اقناع و برانگيختن شگفتي مخاطب به دو نوع شخصيت ايستای متظاهر به پويايي و جامعيت و شخصيت ايستاي تهي از انگيزه پويايي و جامعيت تقسيم مي‏كند. روش پژوهش حاضر توصيفی – تحليلی و مبنای تحليل روايی همان روش "جان پک " است. مهمترين دستاوردهای پژوهش عبارتند از : 1. الگوی نظری تقسيم بندی انواع شخصيت مورگان فورستر به خوبی بر رمان‏های کنفانی قابل انطباق است. 2.خلاقيت شخصيت‏پردازی کنفانی در تلفيق هنرمندانه بين دو شيوة مستقيم و غيرمستقيم نمود يافته است. 3.به جز رمان «الشیء الآخر»که شخصيت‏هايش بسيار متأثر از شرايط حاکم بر جامعة روزگار کنفانی بوده‏، در ساير رمان‏ها اما شخصيت‏های داستانی كنفاني، زاييدة تجارب فردی او در طول زندگی روزمرّه و نمايانگر اشخاصی واقعی هستند که عموماً به طبقة پايين‏دست جامعه منتسب‎‏اند.
ضديّة اليوتوبيا والديستوبيا- قراءة في رواية (قواعد العشق الأربعون) لإليف شافاق
Authors: سعد داحس ناصر ا.م.د. 
Published: December 2022

يسعى البحث الموسوم بـ (ضديّة اليوتوبيا والديستوبيا في رواية قواعد العشق الأربعون لإليف شافاق) إلى إيضاح التضاد الحاصل في المكان الواحد، مدينة (قونية) على المستويين الروحي والواقعي، حينما يكون أحدهما يوتوبيّاً أليفا والآخر ديستوبيّاً معاديّاً، عن طريق مجموعة من الثنائيّات المفهوميّة والإجرائيّة والثقافيّة التي تضمنتها الرواية، والتي قاربت اللقاء المصيري بين (التبريزي) و(الرومي)، وما نتج عنه من انتهاج مذهب صوفي متجدّد كان قطبه (الرومي).
ومن أهم مقوّمات اليوتوبيا التي اعتمد عليها (التبريزي) ورفيقه (الرومي) في مشروعهما لإقامة مدينة فاضلة: الخير، والحب، والسلام، والشعر، والموسيقى، والحركة المنتجة، وقبول الآخر، وإنصاف المرأة، وتقويض الخطاب الذكوري، والمثاقفة الروحيّة، وغير ذلك من المظاهر والصور الإيجابيّة.
أمّا أهم مظاهر الديستوبيا، التي قاومها (التبريزي) و(الرومي)، ووقفا ضدها، والتي شكّلت أساسات المدينة الفاسدة على مستوى الفكر الممارسة: الشر، الكراهيّة، والحرب، وإغفال الشعر الملهم، والصمت، والسكون، ورفض الآخر واضطهاده، واعتماد الخطاب الذكوري الإقصائي، وتجاهل المثاقفة الروحيّة، واعتماد المثاقفة الماديّة، وغير ذلك من المظاهر والصور السلبيّة.
إنّ التضاد بين اليوتوبيا والديستوبيا شغل مساحة كبيرة من الرواية مدار البحث، وظهرت حالة البينونة والافتراق بين العالمين بصورة واضحة من بداية الرواية إلى نهايتها، ولاسيّما في مسارها التاريخي، وهو الأمر الذي وضعنا أمام غاية التقصّي والمقارنة بينهما على وفق المزاوجة بين مرتكزات المتصوّفة الحقيقيّة، ومبادئهم المتخيّلة التي تضمنتها الرواية.
الظواهر الأسلوبية في شعر مسكين الدارمي تشكيل ، معنى ، إقناع
Authors: نضال حسيب فلفل د. 
Published: December 2022

شعر مسكين الدارمي يتميز بمظاهر فنية متعددة شأنها شأن الظواهر الأسلوبية السائدة في عصره إلا أنها تتميز بوصفها أخذت صياغات خاصة عند الشاعر ، إذ إنَّ لكل شاعر أسلوبه الذي يمثل طاقته الخلاقة في نشرها بتقنيات وظفها لطرح أفكاره ، وقد تتوجت بعدَّها مظاهر فنية أنتجت نصوصه الشعرية ؛ لتحقيق رسالته التي يحاول إيصالها إلى المتلقي مستعملاً أولاً مستوىً صوتيا تمثل في الجناس والتكرار، ثانياً : تركيبيا في التضاد وتقديم ما حقه التأخير والقصر، وثالثاً : دلاليا وأورده في الصورة التشبيهية, والتي تفشت في معظم قصائد الديوان ، وفي موضوعات متعددة منها الفخر بشجاعة قومه ، وكرمه ، وفي مدحه ورثائه ، كما وردت في حكمه وإرشاده ، وهو يبث ذلك عبر تقنياته الفنية .