bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inner transitions in higher education in Sweden: incorporating intra-personal skills in education for sustainable development
Authors: Libertson Frans 
Published: May 2023

Purpose
Humanity is facing an unprecedented challenge of climate crises. Rapid changes to the physical environment and living conditions will be accompanied by challenges to mental health and well-being. Consequently, education for sustainable development should also include coping strategies for stress and anxiety. Adding intra-personal skills to the curriculum, such as self-reflection and mindfulness training, could aid in this education. This case study aims to explore the barriers to and drivers for fostering inner transitions through intra-personal skills training and mindfulness.

Design/methodology/approach
This case study from Lund University, Sweden, constitutes a critical case for investigating inner transitions in education. Data collection was designed around semi-structured qualitative interviews, to investigate the barriers to and drivers for intra-personal skills and mindfulness in education for sustainable development at all institutional levels of the university.

Findings
The results indicate that education for sustainable development already includes elements of introspection, albeit informally. However, there is a lack in a fundamental understanding of intra-personal skills and how they relate to other key competences for sustainable development. To make intra-personal skills training a formal component of the education, it must receive the full support from all levels of the university.

Originality/value
The study outlines general recommendations for universities to challenge existing policies while also finding ways to work around them. In the meantime, universities should make intra-personal skills training an informal learning activity. Recognizing that the students’ prior knowledge in this area is a potential asset, universities should collaborate with their students to support student-led intra-personal skills training.
Modeling and calibration of high-order joint-dependent kinematic errors of serial robot based on local POE
Authors: Zhang Yujie , Cui Jing , Li Yang , Chu Zhongyi 
Published: May 2023

Purpose
This paper aims to address the issue of model discontinuity typically encountered in traditional Denavit-Hartenberg (DH) models. To achieve this, we propose the use of a local Product of Exponentials (POE) approach. Additionally, a modified calibration model is presented which takes into account both kinematic errors and high-order joint-dependent kinematic errors. Both kinematic errors and high-order joint-dependent kinematic errors are analyzed to modify the model.

Design/methodology/approach
Robot positioning accuracy is critically important in high-speed and heavy-load manufacturing applications. One essential problem encountered in calibration of series robot is that the traditional methods only consider fitting kinematic errors, while ignoring joint-dependent kinematic errors.

Findings
Laguerre polynomials are chosen to fitting kinematic errors and high-order joint-dependent kinematic errors which can avoid the Runge phenomenon of curve fitting to a great extent. Levenberg–Marquard algorithm, which is insensitive to overparameterization and can effectively deal with redundant parameters, is used to quickly calibrate the modified model. Experiments on an EFFORT ER50 robot are implemented to validate the efficiency of the proposed method; compared with the Chebyshev polynomial calibration methods, the positioning accuracy is improved from 0.2301 to 0.2224 mm.

Originality/value
The results demonstrate the substantial improvement in the absolute positioning accuracy achieved by the proposed calibration methods on an industrial serial robot.
NIST Mass Spectrometry Data Center standard reference libraries and software tools: Application to seized drug analysis
Authors: Wallace William E. , Moorthy Arun S. 
Published: May 2023

AbstractThe standard reference libraries and associated custom software provided by the National Institute of Standards and Technology's Mass Spectrometry Data Center (NIST MSDC) are described with a focus on assisting the seized drug analyst with the identification of fentanyl‐related substances (FRS). These tools are particularly useful when encountering novel substances when no certified sample is available. The MSDC provides three standard reference mass spectral libraries, as well as six software packages for mass spectral analysis, reference library searching, data interpretation, and measurement uncertainty estimation. Each of these libraries and software packages are described with references to the original publications provided. Examples of fentanyl identification by gas chromatography–mass spectrometry (GC–MS) and by direct analysis in real‐time (DART) mass spectrometry are given. A link to online tutorials is provided.
Phylogeny‐based assignment of functional traits to DNA barcodes outperforms distance‐based, in a comparison of approaches
Authors: Xie Tingting , Orr Michael C. , Zhang Dan , Ferrari Rafael R. , Li Yi , Liu Xiuwei , Niu Zeqing , Wang Mingqiang , Zhou Qingsong , Hao Jiasheng , Zhu Chaodong , Chesters Douglas 
Published: May 2023

AbstractThe full potential for using DNA barcodes for profiling functional trait diversity has yet to be determined in plants and animals; thus, we outline a general framework for quantifying functional trait diversity of insect community DNA and propose and assess the accuracy of three methods for achieving this. We built a novel dataset of traits and DNA barcodes for wild bees in China. An informatics framework was developed for phylogeny‐based integration of these data and prediction of traits for any subject barcodes, which was compared with two distance‐based methods. For Phylogenetic Assignment, we additionally conducted a species‐level analysis of publically available bee trait data. Under the specimen‐level dataset, the rate of trait assignment was negatively correlated with distance between the query and the nearest trait‐known reference, for all methods. Phylogenetic Assignment was found to perform best under several criteria; particularly, it had the lowest false‐positive rate (rarely returning a state prediction where success was unlikely; where the distance from query to the nearest reference was high). For a wider range of compiled traits, conservative life‐history traits showed the highest rates of assignment; for example, sociality was predicted with confidence at 53%, parasitism at 44% and nest location at 33%. As outlined herein, automated trait assignment might be applied at scale to either barcodes or metabarcodes. With further compilation and databasing of DNA barcode and trait data, the rate and accuracy of trait assignment is expected to increase to the point of being a widely viable and informative approach.
Investigation and management of the monoclonal gammopathy of undetermined significance
Authors: Stern Simon , Chaudhuri Satarupa , Drayson Mark , Henshaw Sarah , Karunanithi Kamaraj , Willis Fenella ,   the Haemato‐Oncology Task Force of the British Society for Haematology and the UK Myeloma Forum
Published: May 2023

SummaryThis Good Practice Paper provides recommendations for the diagnosis, risk stratification and management of the monoclonal gammopathy of undetermined significance (MGUS). It describes the recently recognised entity of the monoclonal gammopathy of clinical significance (MGCS), and recommends how it should be managed. The potential for targeted population screening for MGUS is also discussed.
bTUNED: transcutaneous tibial nerve stimulation for neurogenic lower urinary tract dysfunction
Authors: Stalder Stephanie A. , Gross Oliver , Anderson Collene E. , Bachmann Lucas M. , Baumann Sarah , Birkhäuser Veronika , Bywater Mirjam , del Popolo Giulio , Engeler Daniel S. , Agrò Enrico Finazzi , Friedl Susanne , Grilo Nuno , Kiss Stephan , Koschorke Miriam , Leitner Lorenz , Liechti Martina D. , Mehnert Ulrich , Musco Stefania , Sadri Helen , Stächele Lara , Tornic Jure , van der Lely Stéphanie , Wyler Stephen , Kessler Thomas M. 
Published: May 2023

ObjectiveTo present the protocol for a randomized controlled trial (RCT) evaluating the efficacy and safety of transcutaneous tibial nerve stimulation (TTNS) for refractory neurogenic lower urinary tract dysfunction (NLUTD).Study Design and ResultsbTUNED (bladder and TranscUtaneous tibial Nerve stimulation for nEurogenic lower urinary tract Dysfunction) is an international multicentre, sham‐controlled, double‐blind RCT investigating the efficacy and safety of TTNS. The primary outcome is success of TTNS, defined as improvements in key bladder diary variables at study end compared to baseline values. The focus of the treatment is defined by the Self‐Assessment Goal Achievement (SAGA) questionnaire. Secondary outcomes are the effect of TTNS on urodynamic, neurophysiological, and bowel function outcome measures, as well as the safety of TTNS.ConclusionsA total of 240 patients with refractory NLUTD will be included and randomized 1:1 into the verum or sham TTNS group from March 2020 until August 2026. TTNS will be performed twice a week for 30 min during 6 weeks. The patients will attend baseline assessments, 12 treatment visits and follow‐up assessments at the study end.
A longitudinal study of how women's prenatal and postnatal concerns related to the COVID‐19 pandemic predicts their infants' social–emotional development
Authors: Wiley Kyle S. , Fox Molly M. , Gildner Theresa E. , Thayer Zaneta M. 
Published: May 2023

AbstractInfant social–emotional development may be impacted by the COVID‐19 pandemic. This study investigated associations between maternal pre‐ and postnatal pandemic‐related concerns and social–emotional developmental risk. Data, collected in 2020–2021, came from 220 mothers (87% white, 6% Hispanic, 1% Black, 3% Asian, 1% American Indian, Mage = 32.46 years), and infants (53.18% male, Mage = 12.98 months) in the United States. Maternal postnatal pandemic‐related concerns were associated with total risk scores (B = 6.09, p‐value <.001) and offspring risk of scoring positive for problems related to inflexibility (B = 4.07, p‐value = .006). The total score association was moderated by self‐reported social support. Infants may be detrimentally impacted by the pandemic via maternal pandemic‐related concerns. Maternal social support may buffer infants.
Facing ambiguity with action
Authors: Duin Cate 
Published: May 2023

AbstractAn insurrection, threats to our election system, and widespread distrust have spurred a national conversation about civic engagement. Many people of faith are responding with a desire to take action. However, the path to action is often deeply ambiguous. How we choose to take action that counts. This article is a personal reflection on how political engagement can animate faith and faith can guide political engagement. It suggests constant reflection on the subtle ways we can be led into complacency or inaction when interacting with political institutions. By reflecting on these mechanisms and connecting with our faith communities, this article posits that people of faith can thoughtfully and boldly make the daily decisions that make up our civic engagement.
Sodium‐glucose cotransporter‐2 inhibitors and kidney outcomes in real‐world type 2 diabetes populations: A systematic review and meta‐analysis of observational studies
Authors: Forbes Anna K. , Suckling Rebecca J. , Hinton William , Feher Michael D. , Banerjee Debasish , Cole Nicholas I. , de Lusignan Simon , Swift Pauline A. 
Published: May 2023

AbstractAimTo conduct a systematic review of observational studies to explore the real‐world kidney benefits of sodium‐glucose cotransporter‐2 (SGLT2) inhibitors in a large and diverse population of adults with type 2 diabetes (T2D).Materials and MethodsWe searched MEDLINE, EMBASE and Web of Science for observational studies that investigated kidney disease progression in adults with T2D treated with SGLT2 inhibitors compared to other glucose‐lowering therapies. Studies published from database inception to July 2022 were independently reviewed by two authors and evaluated using the Risk of Bias in Non‐randomized Studies of Interventions (ROBINS‐I) tool. A random‐effects meta‐analysis was performed on studies with comparable outcome data, reported as hazard ratios (HRs) with 95% confidence intervals (CIs).ResultsWe identified 34 studies performed across 15 countries with a total population of 1 494 373 for inclusion. In the meta‐analysis of 20 studies, SGLT2 inhibitors were associated with a 46% lower risk of kidney failure events compared with other glucose‐lowering drugs (HR 0.54, 95% CI 0.47–0.63). This finding was consistent across multiple sensitivity analyses and was independent of baseline estimated glomerular filtration rate (eGFR) or albuminuria status. SGLT2 inhibitors were associated with a lower risk of kidney failure when compared with dipeptidyl peptidase‐4 inhibitors and a combination of other glucose‐lowering drug classes (HR 0.50, 95% CI 0.38–0.67 and HR 0.51, 95% CI 0.44–0.59, respectively). However, when compared to glucagon‐like peptide 1 receptor agonists there was no statistically significant difference in the risk of kidney failure (HR 0.93, 95% CI 0.80–1.09).ConclusionsThe reno‐protective benefits of SGLT2 inhibitors apply to a broad population of adults with T2D treated in routine clinical practice, including those at lower risk of kidney events with normal eGFR and without albuminuria. These findings support the early use of SGLT2 inhibitors in T2D for preservation of kidney health.
Better to be direct? Evidence from the abolition of direct elections in Italian local governments
Authors: Ferlenga Francesco 
Published: May 2023

AbstractThis paper provides evidence for the importance of direct electoral processes by investigating the consequences for public spending of an unexpected reform that repealed direct elections for local (provincial) politicians in Italy. Direct elections were substituted with indirect ones, whereby directly elected municipal politicians choose a municipal mayor to serve as provincial president. Using a difference‐in‐differences strategy, I document two main consequences of the reform. First, municipalities connected to the provincial presidents tend to receive disproportionately more public funds after the reform, suggesting geographic favoritism increased. Second, the share of provincial resources spent on public goods drops in favor of bureaucratic costs. I discuss suggestive evidence that these results are driven by weaker electoral incentives rather than by the selection of worse politicians.
A potentially new thromboembolic event scoring system in polycythaemia vera patients: An audit of the Hungarian Philadelphia negative chronic myeloproliferative neoplasia register
Authors: Karadi Eva , Dombi Peter , Korom Viktoria Gyorine , Kovacs Eszter , Herczeg Jozsef , Andrikovics Hajnalka , Illes Arpad , Demeter Judit , Homor Lajos , Udvardy Miklós , Egyed Miklós 
Published: May 2023

AbstractObjectiveThe Hungarian National Registry for Philadelphia chromosome negative myeloproliferative neoplasms was used to analyse the thromboembolic events (TE) of Hungarian patients with polycythemia vera (PV).MethodsData from 351 JAK2 V617F‐positive patients diagnosed with PV were collected online from 15 haematology centres reporting clinical characteristics, therapeutic interventions and thromboembolic events. TE events were evaluated before and after diagnosis based upon the Landolfi and Tefferi risk assessment scales.ResultsTE were reported on 102 patients before diagnosis and 100 during the follow‐up period. Comparing to the frequency of major arterial events before PV diagnosis, we can notice a decreasing tendency after diagnosis: from 12.3% to 2.6% (p < .00003). There was no significant change in the rate of major venous events (from 5.1% to 8.5%; p = .1134) or minor arterial events (from 11.7% to 17.4%; p = .073).Bleeding events were recorded in 5.7% of patients. Despite treatment with HU + ASA, 44 patients (43.1%) with prior TE had recurrent thromboembolic complications. The particular analysis of our data revealed a new TE scoring system based on: age, gender, previous TE and iron deficiency at the time of diagnosis.ConclusionsOur registry enables characterisation of patients with PV. The high level of recurrent TE events highlights the need for more effective and risk‐adapted therapy.
Metabolic effects of early life stress and pre‐pregnancy obesity are long lasting and sex specific in mice
Authors: Brix Lea M. , Monleon Daniel , Collado Maria Carmen , Ederveen Thomas H. A. , Toksöz Irmak , Bordes Joeri , van Doeselaar Lotte , Engelhardt Clara , Mitra Shiladitya , Narayan Sowmya , Schmidt Mathias V. 
Published: May 2023

AbstractEarly life stress (ELS) is associated with metabolic, cognitive, and psychiatric diseases and has a very high prevalence, highlighting the urgent need for a better understanding of the versatile physiological changes and identification of predictive biomarkers. In addition to programming the hypothalamic–pituitary–adrenal (HPA) axis, ELS may also affect the gut microbiota and metabolome, opening up a promising research direction for identifying early biomarkers of ELS‐induced (mal)adaptation. Other factors affecting these parameters include maternal metabolic status and diet, with maternal obesity shown to predispose offspring to later metabolic disease. The aim of the present study was to investigate the long‐term effects of ELS and maternal obesity on the metabolic and stress phenotype of rodent offspring. To this end, offspring of both sexes were subjected to an adverse early‐life experience, and their metabolic and stress phenotypes were examined. In addition, we assessed whether a prenatal maternal and an adult high‐fat diet (HFD) stressor further shape observed ELS‐induced phenotypes. We show that ELS has long‐term effects on male body weight (BW) across the lifespan, whereas females more successfully counteract ELS‐induced weight loss, possibly by adapting their microbiota, thereby stabilizing a balanced metabolome. Furthermore, the metabolic effects of a maternal HFD on BW are exclusively triggered by a dietary challenge in adult offspring and are more pronounced in males than in females. Overall, our study suggests that the female microbiota protects against an ELS challenge, rendering them more resilient to additional maternal‐ and adult nutritional stressors than males.
Time‐dependent impact of type 2 diabetes mellitus on incident prodromal Alzheimer disease: A longitudinal study in 1395 participants
Authors: Luo Tong , Tu Yun‐Feng , Huang Shan , Ma Yuan‐Yuan , Wang Qing‐Hua , Wang Yan‐Jiang , Wang Jun ,   Alzheimer's Disease Neuroimaging Initiative
Published: May 2023

AbstractBackground and purposeThis study was undertaken to investigate the longitudinal impact of type 2 diabetes mellitus (T2DM) on the prodromal and dementia stages of Alzheimer disease (AD), focusing on diabetes duration and other comorbidities.MethodsA total of 1395 dementia‐free individuals aged 55–90 years with maximum 15‐year follow‐up data were enrolled from the Alzheimer's Disease Neuroimaging Initiative database. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) of the incidence of prodromal or dementia stages of AD.ResultsLonger T2DM duration (≥5 years; multiadjusted HR = 2.19, 95% confidence interval [CI] = 1.05–4.58), but not shorter T2DM duration (<5 years), was associated with a significantly increased risk of incident prodromal AD over a mean follow‐up of 4.8 years. APOE ε4 allele (HR = 3.32, 95% CI = 1.41–7.79) and comorbid coronary artery disease (CAD; HR = 3.20, 95% CI = 1.29–7.95) further increased the risk of incident prodromal AD in patients with T2DM. No significant association was observed between T2DM and the risk of progression from prodromal AD to AD dementia.ConclusionsT2DM, which is characterized by a longer duration, increases the incidence risk of prodromal AD but not AD dementia. APOE ε4 allele and comorbid CAD strengthen the relationship between T2DM and prodromal AD. These findings highlight T2DM characteristics and its comorbidities as predictors for accurate prediction of AD and screening of at‐risk populations.
A novel KCNC1 gain‐of‐function variant causing developmental and epileptic encephalopathy: “Precision medicine” approach with fluoxetine
Authors: Ambrosino Paolo , Ragona Francesca , Mosca Ilaria , Vannicola Chiara , Canafoglia Laura , Solazzi Roberta , Rivolta Ilaria , Freri Elena , Granata Tiziana , Messina Giuliana , Castellotti Barbara , Gellera Cinzia , Soldovieri Maria Virginia , DiFrancesco Jacopo Cosimo , Taglialatela Maurizio 
Published: May 2023

AbstractVariable phenotypes, including developmental encephalopathy with (DEE) or without seizures and myoclonic epilepsy and ataxia due to potassium channel mutation, are caused by pathogenetic variants in KCNC1, encoding for Kv3.1 channel subunits. In vitro, channels carrying most KCNC1 pathogenic variants display loss‐of‐function features. Here, we describe a child affected by DEE with fever‐triggered seizures, caused by a novel de novo heterozygous missense KCNC1 variant (c.1273G>A; V425M). Patch‐clamp recordings in transiently transfected CHO cells revealed that, compared to wild‐type, Kv3.1 V425M currents (1) were larger, with membrane potentials between −40 and +40 mV; (2) displayed a hyperpolarizing shift in activation gating; (3) failed to inactivate; and (4) had slower activation and deactivation kinetics, consistent with a mixed functional pattern with prevalent gain‐of‐function effects. Exposure to the antidepressant drug fluoxetine inhibited currents expressed by both wild‐type and mutant Kv3.1 channels. Treatment of the proband with fluoxetine led to a rapid and prolonged clinical amelioration, with the disappearance of seizures and an improvement in balance, gross motor skills, and oculomotor coordination. These results suggest that drug repurposing based on the specific genetic defect may provide an effective personalized treatment for KCNC1‐related DEEs.
Women as leaders in male‐dominated sectors: A bifocal analysis of gendered organizational practices
Authors: O’Brien Wendy , Hanlon Clare , Apostolopoulos Vasso 
Published: May 2023

AbstractWomen in male‐dominated sectors face significant challenges to progress their leadership aspirations. While organizations have activated policies and practices that ostensibly assist women to progress, they still face entrenched gendered practices and cultures that create ongoing obstacles. In this paper, we examine the gendered social practices from insights of 15 women leaders in Australia as they attempt to advance their careers. In particular, on formal policies, informal practices, narratives and social interactions, and informal patterns of unconscious bias and merit, they negotiate in three male‐dominated sectors: Trades, Sport, and Surgery. The findings indicate a disconnect between policies and their application. Women were conflicted about the importance of quotas, and often felt unable to access flexible work arrangements upon returning to work after parental leave. Career pathways were often unclear, and women felt a lack of support from their organization, particularly when they attempted to navigate dominant masculine cultures. Drawing on these findings, we argue that executive leaders are central to changing the systemic sexism and discrimination in organizations that persist in male‐dominated sectors. To create organizational changes necessary for women to step into leadership roles, we propose four target areas: create accessible and visible career pathways, provide networking support, activate mentoring opportunities, and address unconscious bias.