bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semi-supervised exercise training program more effective for individuals with postural orthostatic tachycardia syndrome in randomized controlled trial
Authors: Wheatley-Guy Courtney M. , Shea Meredith G. , Parks Jordan K. , Scales Robert , Goodman Brent P. , Butterfield Richard J. , Johnson Bruce D. 
Published: August 2023

Abstract
Purpose
Exercise like any medication requires the correct dose; to be effective the appropriate frequency, duration, and intensity are necessary. This study aimed to assess if a semi-supervised exercise training (ET) program would be more effective at improving aerobic fitness (VO2PEAK), exercise tolerance, and symptoms in individuals with postural orthostatic tachycardia syndrome (POTS) compared to the standard of care (SOC).

Methods
Subjects were randomized to either the ET or SOC groups (n 26 vs. 23; age 33 ± 11 vs. 37 ± 10 years; VO2PEAK 66 ± 15 vs. 62 ± 15% predicted, ET vs. SOC respectively, p > 0.05). Composite Autonomic Symptom Score (COMPASS 31), 10 min stand test, and cardiopulmonary exercise test were performed at baseline and following 12 weeks. The ET group received an exercise consultation and eight semi-supervised in-person or virtual exercise sessions.

Results
The ET group demonstrated a greater improvement in VO2PEAK, higher or longer tolerance for baseline peak workload, and more often had a delayed symptom onset with exercise than the SOC group (ΔVO2PEAK 3.4 vs. − 0.2 mL/min/kg, p < 0.0001, ΔWorkload 19 ± 17 vs. 0 ± 10 W; Workload time 63 ± 29 vs. 22 ± 30 s; onset-delay 80% vs. 30%, p < 0.05). Individuals in the ET group reported a significant improvement in orthostatic intolerance domain score (p = 0.02), but there was not a significant difference in the improvement in total COMPASS score (− 11.38 vs. − 6.49, p = 0.09).

Conclusion
Exercise training was more effective with greater improvements in aerobic fitness, orthostatic symptoms, and exercise tolerance for individuals with POTS when intensity and progression were personalized and delivered with minimal supervision compared to the SOC.
Non-breeding sites, loop migration and flight activity patterns over the annual cycle in the Lesser Grey Shrike Lanius minor from a north-western edge of its range
Authors: Adamík Peter , Wong Joanna B. , Hahn Steffen , Krištín Anton 
Published: August 2023

AbstractThe Lesser Grey Shrike is a typical Palaearctic songbird for which we have limited knowledge of its migration ecology. All that is known about its non-breeding movements is inferred from observational data of birds on passage. The few available ring recovery data do not link breeding and African non-breeding grounds. By deploying two types of loggers, light-level geolocators and multi-sensor loggers, on birds from a declining Slovak breeding population, we present the first direct evidence for non-breeding grounds, loop migration, stopover sites and the timing of annual cycle events. With barometric data, we provide details on flight altitudes during migration. The two tracked birds migrated in a clear anti-clockwise loop to S Africa. Autumn migration tracks went through the Balkan Peninsula, Mediterranean Sea towards Libya with unusually long stays around N Chad and Niger. The next stopovers were in Angola, and the main non-breeding sites were in Botswana. Spring migration commenced on March 29 and April 7 and the birds took routes along East African countries, with stopovers later in Somalia and Saudi Arabia, before crossing the eastern Mediterranean Sea. Nocturnal migration dominated, but for three days in August, while crossing the Sahara Desert, the bird extended flights into the day with a sudden increase in flight altitudes at dawn. Flight altitudes were higher during barrier crossing and during the last phase of spring migration compared to the remaining periods, with the most extreme event recorded at 4530 m asl.
Quantitative version of Weyl’s law
Authors: Savale Nikhil 
Published: August 2023

AbstractWe prove a general estimate for the Weyl remainder of an elliptic, semiclassical pseudodifferential operator in terms of volumes of recurrence sets for the Hamilton flow of its principal symbol. This quantifies earlier results of Volovoy (Comm Partial Differential Equations 15:1509–1563, 1990; Ann Global Anal Geom 8:127–136, 1990). Our result particularly improves Weyl remainder exponents for compact Lie groups and surfaces of revolution. And gives a quantitative estimate for Bérard’s Weyl remainder in terms of the maximal expansion rate and topological entropy of the geodesic flow.
Antidepressant Prescription Behavior Among Primary Care Clinician Providers After an Interprofessional Primary Care Psychiatric Training Program
Authors: Huo Shutong , Bruckner Tim A. , Xiong Glen L. , Cooper Emma , Wade Amy , Neikrug Ariel B. , Gagliardi Jane P. , McCarron Robert 
Published: August 2023

AbstractPrimary care providers (PCPs) are increasingly called upon to screen for and treat depression. However, PCPs often lack the training to diagnose and treat depression. We designed an innovative 12-month evidence and mentorship-based primary care psychiatric training program entitled the University of California, Irvine (UCI) School of Medicine Train New Trainers Primary Care Psychiatry (TNT PCP) Fellowship and examined whether this training impacted clinician prescription rates for antidepressants. We retrieved information on 18,844 patients and 192 PCPs from a publicly insured health program in Southern California receiving care between 2017 and 2021. Of the 192 PCPs, 42 received TNT training and 150 did not. We considered a patient as exposed to the provider’s TNT treatment if they received care from a provider after the provider completed the 1-year fellowship. We utilized the number of antidepressant prescriptions per patient, per quarter-year as the dependent variable. Linear regression models controlled for provider characteristics and time trends. Robustness checks included clustering patients by provider identification. After PCPs completed TNT training, “exposed” patients received 0.154 more antidepressant prescriptions per quarter-year relative to expected levels (p < 0.01). Clustering of standard errors by provider characteristics reduced precision of the estimate (p < 0.10) but the direction and magnitude of the results were unchanged. Early results from the UCI TNT PCP Fellowship demonstrate enhanced antidepressant prescription behavior in PCPs who have undergone TNT training. A novel, and relatively low-cost, clinician training program holds the potential to empower PCPs to optimally deliver depression treatment.
A trust-region approach for computing Pareto fronts in multiobjective optimization
Authors: Mohammadi A. , Custódio A. L. 
Published: August 2023

AbstractMultiobjective optimization is a challenging scientific area, where the conflicting nature of the different objectives to be optimized changes the concept of problem solution, which is no longer a single point but a set of points, namely the Pareto front. In a posteriori preferences approach, when the decision maker is unable to rank objectives before the optimization, it is important to develop algorithms that generate approximations to the complete Pareto front of a multiobjective optimization problem, making clear the trade-offs between the different objectives. In this work, an algorithm based on a trust-region approach is proposed to approximate the set of Pareto critical points of a multiobjective optimization problem. Derivatives are assumed to be known, allowing the computation of Taylor models for the different objective function components, which will be minimized in two main steps: the extreme point step and the scalarization step. The goal of the extreme point step is to expand the approximation to the Pareto front, by moving towards the extreme points of it, corresponding to the individual minimization of each objective function component. The scalarization step attempts to reduce the gaps on the Pareto front, by solving adequate scalarization problems. The convergence of the method is analyzed and numerical experiments are reported, indicating the relevance of each feature included in the algorithmic structure and its competitiveness, by comparison against a state-of-art multiobjective optimization algorithm.
Using a Service Lens to Better Understand Practices –and Vice Versa
Authors: Farshchian Babak A. , Mikalsen Marius 
Published: August 2023

AbstractMany studies of practices involve service exchange, and many service researchers have discovered the central role that sociotechnical practices play in service –in particular, within the service-dominant logic school of thought. In this paper, we propose an analytical lens that builds on this mutual interest to understand complex practices involving service exchange. Practice researchers can gain new insights regarding practices embedded in service ecosystems. At the same time, service researchers can better explain actor behavior by looking deeper at sociotechnical practices. We develop a concept toolbox based on practice and service-dominant logic research literature. We illustrate the usefulness of the toolbox through an interpretative case study of public service to include children with disabilities in leisure activities. Seeing practices as parts of larger multi-stakeholder service ecosystems 1) can help us better explain behavior in those practices and understand how they are affected by other overlapping practices, 2) brings forward the importance of value and how multiple actors need to interact in order to create value for each other, and 3) enriches service-dominant logic with a focus on sociotechnical aspects that are central to many practice studies.
Enhancing Swedish Toddlers’ Learning Opportunities Through Interactions with Pictures and Narrative Designed for Numerical Learning Purposes
Authors: Björklund Camilla , Palmér Hanna 
Published: August 2023

Abstract
The aim of this study is to deepen the understanding of how preschool teachers can use representations of different kinds to bring fore the mathematical content that may be afforded in pictures and narrative designed for numerical learning purposes. Seventy-three video documentations of reading sessions with 27 toddlers (1–3 years of age) over the course of three semesters were analyzed with a focus on number-oriented actions that, theoretically, would facilitate toddlers’ learning of numbers. In the reading sessions the teachers extended the content of the pictures and the narrative in different ways, and how one and the same picture was handled was shown to impact on what was made possible for the children to discern. Three different objects of learning—identifying numbers, comparing numbers, and operating on numbers—were made visible. Further, the use of gestures strengthened the possibility for the children to make connections within and between representations. This contributes to our understanding of the importance of using representations and gestures with a pedagogical purpose.
Iterated AGM Revision Based on Probability Revision
Authors: Hansson Sven Ove 
Published: August 2023

AbstractClose connections between probability theory and the theory of belief change emerge if the codomain of probability functions is extended from the real-valued interval [0, 1] to a hyperreal interval with the same limits. Full beliefs are identified as propositions with a probability at most infinitesimally smaller than 1. Full beliefs can then be given up, and changes in the set of full beliefs follow a pattern very close to that of AGM revision. In this contribution, iterated revision is investigated. The iterated changes in the set of full beliefs generated by repeated revisions of a hyperreal probability function can, semantically, be modelled with the same basic structure as the sphere models of belief change theory. The changes on the set of full beliefs induced by probability revision satisfy the Darwiche–Pearl postulates for iterated belief change.
An analytical model for the static behaviour of honeycomb sandwich plates with auxetic cores using higher-order shear deformation theories
Authors: Karimi Mahdi , Khoshgoftar Mohammad Javad , Karimi Mohammad , Mirzaali Mohammad Javad , Javanbakht Zia 
Published: August 2023

AbstractThis paper presents an analytical model to investigate the static behaviour of sandwich plates comprised of two isotropic face sheets and a honeycomb core. Through-thickness transverse shear stresses were considered using a unified displacement field with which various plate theories were implemented, i.e., exponential, third-order, hyperbolic, sinusoidal, fifth-order, Mindlin, and the classic plate theory. The equilibrium equations of a simply-supported sandwich panel were derived using the principle of virtual work and Navier solution was obtained under static transverse loading. After validating of the model, various mechanical and geometrical parameters were varied to characterise the behaviour of the structure under regular and auxetic response. It was found that the auxeticity of the core strongly affects the mechanical response, e.g., in controlling deflection, in-plane anisotropy, and Poisson’s ratio. Cell wall angle was found to be most critical parameter that can be used to adjust anisotropy, out-of-plane shear modulus, transverse shear stress distribution, and deflection of the panel. Also the cell aspect ratio controls the sensitivity of the core response to other geometrical variations. In terms of the higher-order theories, the deflection-dependent parameter of the unified formulation seems to have more control of maximum deflection compared to independent rotations. Auxeticity of the core showed some benefits in controlling anisotropy, deflection and providing additional out-of-plane shear rigidity. Overall, since there is not one-to-one relationship between specific values of Poisson’s ratio, anisotropy, and shear rigidity, careful design considerations must be invested to obtain a correct mechanical response.
A comparative exergy-based assessment of direct air capture technologies
Authors: Hoseinpoori Sina , Pallarès David , Johnsson Filip , Thunman Henrik 
Published: August 2023

AbstractThe 6th Assessment of the IPCC underlined the need for urgent measures for carbon dioxide removal from the atmosphere, so as to meet the 1.5 °C goal by the end of this century. One option to achieve this is direct air capture (DAC) technologies. This work assesses the thermodynamic performances of different categories of DAC technologies, i.e., adsorption-based, absorption-based, ion exchange, and electrochemical. An exergy analysis is performed on the DAC processes in each category to identify hotspots for efficiency loss within the system. The results show that the consumption of materials is responsible for 5–40% of the exergy consumption of the most-developed DAC processes. Despite their greater use of materials compared to absorption-based processes, adsorption-based processes, together with ion exchange technologies, have the highest exergy efficiencies of the DAC technologies investigated. Moreover, the results highlight the importance of limiting material consumption and electrifying large-scale DAC plants, which cannot run exclusively on waste heat from industrial processes.
The implications of N6-methyladenosine (m6A) modification in esophageal carcinoma
Authors: He Cheng , Teng Xiao , Wang Luming , Ni Miaoqi , Zhu Linhai , Liu Jiacong , Lv Wang , Hu Jian 
Published: August 2023

AbstractEsophageal carcinoma (EC) is always diagnosed at advanced stage and its the mortality rate remains high. The patients usually miss the best opportunity for treatment because of non-specific symptoms and the survival rates are low. N6-methyladenosine (m6A) the predominant modification in eukaryotic messenger RNA(mRNA), serves vital roles in numerous bioprocess. This chemical modification is dynamic, reversible and consists of three regulators: m6A methyltransferases (writers), demethylases (erasers) and m6A-binding proteins (readers). Recently, a growing number of evidences have indicated relationships between m6A and EC. Whereas, lacking of cognition about the molecular mechanism of m6A modification in esophageal carcinoma. We will focus on the biological function roles of m6A modification in the tumorigenesis and development of EC. Recent studies showed that immunotherapy had a positive impact on EC. The relationship between m6A and immunotherapy in EC deserves further research and discussion. We will also discuss the potential clinical applications regarding diagnosis, treatment and prognosis of m6A modification for EC and provide perspectives for further studies.
Low bleeding acceptance is associated with increased death risk in patients with atrial fibrillation on oral anticoagulation
Authors: Rusin Gabriela , Konieczyńska Małgorzata , Natorska Joanna , Malinowski Krzysztof Piotr , Undas Anetta 
Published: August 2023

AbstractBleeding is the most feared complication of anticoagulation. We sought to investigate whether the bleeding risk acceptance has a prognostic value during long-term follow-up in the era of direct oral anticoagulants (DOACs) among patients with atrial fibrillation (AF). We studied 167 consecutive AF outpatients [aged 68.8 SD 10.6 years; 141 (84.4%) on DOACs]. The bleeding acceptance was assessed based on the Bleeding Ratio defined as the declared maximum number of major bleedings that a patient would be willing to accept to prevent one major stroke. We recorded cerebrovascular ischemic events, major or clinically relevant non-major bleeds (CRNMB), and mortality. A median Bleeding Ratio was 4 (IQR 2–5). During follow-up of 946 patient-years, cerebrovascular ischemic events and/or death were observed in 28 patients (3.3%/ year) and major bleeding or CRNMB in 33 (4.6%/ year). The Bleeding Ratio was lower in patients who experienced cerebrovascular events or death (p = 0.004), but not bleeding. Patients with the Bleeding Ratio 0–3 were more often non-persistent to the OAC therapy, and more likely to have cerebrovascular event or die than those with higher bleeding acceptance (odds ratio 2.55; 0.95% CI 1.08–6.02) which was driven by the impact on mortality. The multiple Cox proportional hazards model showed that lower Bleeding Ratio, higher CHA2DS2-VASc score, and older age predicted cerebrovascular events or death during follow-up. AF patients who are willing to accept fewer serious bleedings to avoid major stroke during anticoagulation are more likely to experience death and/or cerebrovascular ischemic events, but not bleeding, what might be related to non-persistence.
PoroTwin: A Digital Twin for a FluidFlower Rig
Authors: Keilegavlen Eirik , Fonn Eivind , Johannessen Kjetil , Eikehaug Kristoffer , Both Jakub W. , Fernø Martin , Kvamsdal Trond , Rasheed Adil , Nordbotten Jan M. 
Published: August 2023

AbstractWe present a framework for integrated experiments and simulations of tracer transport in heterogeneous porous media using digital twin technology. The physical asset in our setup is a meter-scale FluidFlower rig. The digital twin consists of a traditional physics-based forward simulation tool and a correction technique which compensates for mismatches between simulation results and observations. The latter augments the range of the physics-based simulation and allows us to bridge the gap between simulation and experiments in a quantitative sense. We describe the setup of the physical and digital twin, including data transfer protocols using cloud technology. The accuracy of the digital twin is demonstrated on a case with artificially high diffusion that must be compensated by the correction approach, as well as by simulations in geologically complex media. The digital twin is then applied to control tracer transport by manipulating fluid injection and production in the experimental rig, thereby enabling two-way coupling between the physical and digital twins.
Five Years Measuring the Muck: Evaluating Interannual Variability of Nutrient Loads From Tidal Flooding
Authors: Macías-Tapia Alfonso , Mulholland Margaret R. , Selden Corday R. , Loftis J. Derek , Bernhardt Peter W. 
Published: August 2023

AbstractDue to sea level rise, tidal flooding is now common in low-lying coastal systems around the world. Yet, the contribution of tidal flooding to non-point source nutrient loads and their impact on the quality of adjacent waters remains poorly constrained. Here, we quantified dissolved nutrient loading and Enterococcus abundance during annual autumnal king tides (i.e., perigean spring tides), between 2017 and 2021, in a sub-watershed of the lower Chesapeake Bay. To calculate nutrient loading from tidal flooding, we used geospatial inundation depths from a street-level hydrodynamic model to estimate floodwater volumes during each of the five sampling events and the difference between nutrient concentrations in floodwater and pre-flood measurements. Results showed that dissolved nutrient concentrations were higher in floodwaters than in estuarine waters and resulted in dissolved nitrogen and phosphorus loads that reached 58.4 × 103 kg and 14.4 × 103 kg, respectively. We compared our load estimates to the tributary-specific total and land-based federal allocations (i.e., total maximum daily loads (TMDL)) for total nitrogen (TN) and total phosphorus (TP). Even the more conservative calculations indicate that inputs of dissolved nutrients during a single tidal flooding event can exceed 100% of the annual load allocation. Additionally, more than 80% of the floodwater samples collected each year showed Enterococcus abundance that exceeded the threshold for recreational water use in Virginia (104 MPN 100 ml−1). Failing to account for non-point source loading of nutrients and contaminants from tidal flooding as sea level rises could result in worsening eutrophication and deterioration of coastal economies and the health of coastal communities around the world.
Does the Location in Science and Technology Parks Foster the Employment Growth of Firms?
Authors: da Silva Martins Júlio Paulo , Rodríguez-Gulías María Jesús , Rodeiro-Pazos David , Rios-Rodríguez Raul 
Published: August 2023

AbstractOne of the main objectives of science and technology parks (STPs) is to contribute to regional development through the creation of skilled jobs in the territory where they are located. However, despite the expansion of these infrastructures over the last decades and the governmental support they receive, there is very little empirical evidence on how these infrastructures affect the employment growth of the firms located there. The aim of this paper is to examine whether the location in STPs has positive effects on employment growth at the firm level. We analysed a sample of 553 Portuguese firms located on STPs and a control group of the same size of comparable firms located outside STPs, applying a dynamic panel data model methodology. The empirical evidence does not allow to prove that location in STPs has positive effects on employment growth, which raises the need to rethink the policies supporting these parks.