bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scaling up gas and electric cooking in low- and middle-income countries: climate threat or mitigation strategy with co-benefits?
Authors: Floess Emily , Grieshop Andrew , Puzzolo Elisa , Pope Dan , Leach Nicholas , Smith Christopher J , Gill-Wiehl Annelise , Landesman Katherine , Bailis Rob 
Published: February 2023

Abstract
Nearly three billion people in low- and middle-income countries (LMICs) rely on polluting fuels, resulting in millions of avoidable deaths annually. Polluting fuels also emit short-lived climate forcers (SLCFs) and greenhouse gases (GHGs). Liquefied petroleum gas (LPG) and grid-based electricity are scalable alternatives to polluting fuels but have raised climate and health concerns. Here, we compare emissions and climate impacts of a business-as-usual household cooking fuel trajectory to four large-scale transitions to gas and/or grid electricity in 77 LMICs. We account for upstream and end-use emissions from gas and electric cooking, assuming electrical grids evolve according to the 2022 World Energy Outlook’s ‘Stated Policies’ Scenario. We input the emissions into a reduced-complexity climate model to estimate radiative forcing and temperature changes associated with each scenario. We find full transitions to LPG and/or electricity decrease emissions from both well-mixed GHG and SLCFs, resulting in a roughly 5 millikelvin global temperature reduction by 2040. Transitions to LPG and/or electricity also reduce annual emissions of PM2.5 by over 6 Mt (99%) by 2040, which would substantially lower health risks from household air pollution. Full transitions to LPG or grid electricity in LMICs improve climate impacts over BAU trajectories.
Impacts of climate change on subannual hydropower generation: a multi-model assessment of the United States federal hydropower plant
Authors: Zhou Tian , Kao Shih-Chieh , Xu Wenwei , Gangrade Sudershan , Voisin Nathalie 
Published: February 2023

AbstractHydropower is a low-carbon emission renewable energy source that provides competitive and flexible electricity generation and is essential to the evolving power grid in the context of decarbonization. Assessing hydropower availability in a changing climate is technically challenging because there is a lack of consensus in the modeling representation of key dynamics across scales and processes. Focusing on 132 US federal hydropower plants, in this study we evaluate the compounded impact of climate and reservoir-hydropower models’ structural uncertainties on monthly hydropower projections. In particular, instead of relying on one single regression-based hydropower model, we introduce another conceptual reservoir operations-hydropower model in the assessment framework. This multi-model assessment approach allows us to partition uncertainties associated with both climate and hydropower models for better clarity. Results suggest that while at least 70% of the uncertainties at the annual scale and 50% at the seasonal scale can be attributed to the choice of climate models, up to 50% of seasonal variability can be attributed to the choice of hydropower models, particularly in regions over the western US where the reservoir storage is substantial. The analysis identifies regions where multi-model assessments are needed and presents a novel approach to partition uncertainties in hydropower projections. Another outcome includes an updated evaluation of Coupled Model Intercomparison Project Phase 5 (CMIP5)-based federal hydropower projection, at the monthly scale and with a larger ensemble, which can provide a baseline for understanding future assessments based on CMIP6 and beyond.
Massive intentional enoxaparin overdose managed with minimal protamine: A single case report
Authors: de Olano Jonathan , Howland Mary Ann , Su Mark K 
Published: February 2023

Abstract

Purpose
The case of a patient with a massive acute enoxaparin overdose managed with observation and minimal doses of protamine sulfate is reported.

Summary
Acute enoxaparin overdoses are uncommonly reported and management is widely variable. A 25-year-old man presented to the emergency department (ED) shortly after reporting that he had attempted suicide by injecting himself with 31 syringes of 80 mg of enoxaparin (a total of 2,480 mg) in the abdomen and other areas of his body. The patient also had self-inflicted superficial lacerations of the forearm. Due to concern over suspected compartment syndrome in the forearm, 25 mg of protamine was administered. Approximately 11 hours after reported enoxaparin self-injection, the patient’s activated partial thromboplastin time (aPTT) was 206 seconds, prompting administration of an additional 50 mg of protamine. Three hours later, the aPTT had decreased to 79 seconds, then rose over several hours to 127 seconds before gradually declining to normal values. Protamine administration had no appreciable impact on anti–factor Xa activity. The patient did not require any blood products during the hospital admission. There were no further complications, and the patient was discharged to the inpatient psychiatry service on hospital day 8.

Conclusion
The case highlights the role of protamine as a reversal agent in the management of low-molecular-weight heparin overdoses. The optimal dosing and efficacy of protamine for this indication needs further investigation.
Detecting early-warning signals for influenza by dysregulated dynamic network biomarkers
Authors: Huo Yanhao , Li Chuchu , Li Yujie , Li Xianbin , Xu Peng , Bao Zhenshen , Liu Wenbin 
Published: February 2023

Abstract
As a dynamical system, complex disease always has a sudden state transition at the tipping point, which is the result of the long-term accumulation of abnormal regulations. This paper proposes a novel approach to detect the early-warning signals of influenza A (H3N2 and H1N1) outbreaks by dysregulated dynamic network biomarkers (dysregulated DNBs) for individuals. The results of cross-validation show that our approach can detect early-warning signals before the symptom appears successfully. Unlike the traditional DNBs, our dysregulated DNBs are anchored and very few, which is essential for disease early diagnosis in clinical practice. Moreover, the genes of dysregulated DNBs are significantly enriched in the influenza-related pathways. The source code of this paper can be freely downloaded from https://github.com/YanhaoHuo/dysregulated-DNBs.git.
Generalizations of the genomic rank distance to indels
Authors: Pereira Zanetti João Paulo , Peres Oliveira Lucas , Chindelevitch Leonid , Meidanis João 
Published: February 2023

AbstractMotivationThe rank distance model represents genome rearrangements in multi-chromosomal genomes as matrix operations, which allows the reconstruction of parsimonious histories of evolution by rearrangements. We seek to generalize this model by allowing for genomes with different gene content, to accommodate a broader range of biological contexts. We approach this generalization by using a matrix representation of genomes. This leads to simple distance formulas and sorting algorithms for genomes with different gene contents, but without duplications.ResultsWe generalize the rank distance to genomes with different gene content in two different ways. The first approach adds insertions, deletions and the substitution of a single extremity to the basic operations. We show how to efficiently compute this distance. To avoid genomes with incomplete markers, our alternative distance, the rank-indel distance, only uses insertions and deletions of entire chromosomes. We construct phylogenetic trees with our distances and the DCJ-Indel distance for simulated data and real prokaryotic genomes, and compare them against reference trees. For simulated data, our distances outperform the DCJ-Indel distance using the Quartet metric as baseline. This suggests that rank distances are more robust for comparing distantly related species. For real prokaryotic genomes, all rearrangement-based distances yield phylogenetic trees that are topologically distant from the reference (65% similarity with Quartet metric), but are able to cluster related species within their respective clades and distinguish the Shigella strains as the farthest relative of the Escherichia coli strains, a feature not seen in the reference tree.Availability and implementationCode and instructions are available at https://github.com/meidanis-lab/rank-indel.Supplementary informationSupplementary data are available at Bioinformatics online.
Influenza vaccination in patients affected by diabetes
Authors: Verket Marlo , Jacobsen Malte , Schütt Katharina , Marx Nikolaus , Müller-Wieland Dirk 
Published: February 2023

AbstractType 2 diabetes, obesity-related metabolic syndrome, and insulin resistance are the most common metabolic disorders associated with increased cardiovascular risk. In addition, patients with Type 2 diabetes have an increased risk for a more severe course of influenza virus infection, a common pandemic. There is increasing evidence that influenza vaccination in patients with diabetes can safely and effectively reduce all-cause mortality and cardiovascular death. The effects of vaccination appear to be more effective when using higher-dose and quadrivalent vaccines, although subgroup-specific separate analyses in patients with diabetes are lacking. Clinical recommendations address influenza vaccination in all adults with diabetes. From our point of view, it should be an integral part of treatment strategies in patients with diabetes.
Time-domain source parameter estimation ofMw 3–7 earthquakes in Japan from a large database of moment-rate functions
Authors: Yoshida Keisuke , Kanamori Hiroo 
Published: February 2023

SUMMARYTime-domain analyses of seismic waveforms have revealed diverse source complexity in large earthquakes (Mw &gt; 7). However, source characteristics of small earthquakes have been studied by assuming a simple rupture pattern on the frequency domain. This study utilizes high-quality seismic network data from Japan to systematically address the source complexities and radiated energies of Mw 3–7 earthquakes on the time domain. We first determine the apparent moment-rate functions (AMRFs) of the earthquakes using the empirical Green's functions. Some of the AMRFs show multiple peaks, suggesting complex ruptures at multiple patches. We then estimate the radiated energies (ER) of 1736 events having more than ten reliable AMRFs. The scaled energy (eR = ER/M0) does not strongly depend on the seismic moment (M0), focal mechanisms, or depth. The median value of eR is 3.7 × 10−5, which is comparable to those of previous studies; however, eR varies by approximately one order of magnitude among earthquakes. We measure the source complexity based on the radiated energy enhancement factor (REEF). The values of REEF differ among earthquakes, implying diverse source complexity. The values of REEF do not show strong scale dependence for Mw 3–7 earthquakes, suggesting that the source diversity of smaller earthquakes is similar to that of larger earthquakes at their representative spatial scales. Applying a simple spectral model (e.g. the ω2-source model) to complex ruptures may produce substantial estimation errors in source parameters.
Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1
Authors: Poveda Eva , Fitzgerald Wendy , Reglero Cristina , Pérez-González Alexandre , Mariño Ana , Álvarez Hortensia , Valcarce Nieves , Llibre Josep Maria , Guillén Santiago Moreno , Muñoz Fernández Maria Angeles , Ruiz-Mateos Ezequiel , Margolis Leonid , Lederman Michael M , Freeman Michael L 
Published: February 2023

Abstract
Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Median EV-associated cytokine levels were higher among PWH than HIV-uninfected. EC showed the highest levels of EV-associated cytokines among PWH with PC levels higher than TC levels. IL-18 levels best distinguished PWH from uninfected controls, and EC from ART-treated, and IL-3 distinguished PC from TC. The role of EV-cytokines in intercellular communication and endogenous control of HIV expression should be investigated further.
The lymphatic endothelium-derived follistatin: activin A axis regulates neutrophil motility in response to Pseudomonas aeruginosa
Authors: McMinn Patrick H , Ahmed Adeel , Huttenlocher Anna , Beebe David J , Kerr Sheena C 
Published: February 2023

Abstract
The lymphatic system plays an active role during infection, however the role of lymphatic-neutrophil interactions in host-defense responses is not well understood. During infection with pathogens such as Pseudomonas aeruginosa, Staphylococcus aureus and Yersinia pestis, neutrophils traffic from sites of infection through the lymphatic vasculature, to draining lymph nodes to interact with resident lymphocytes. This process is poorly understood, in part, due to the lack of in vitro models of the lymphatic system. Here we use a 3D microscale lymphatic vessel model to examine neutrophil–lymphatic cell interactions during host defense responses to pathogens. In previous work, we have shown that follistatin is secreted at high concentrations by lymphatic endothelial cells during inflammation. Follistatin inhibits activin A, a member of the TGF-β superfamily, and, together, these molecules form a signaling pathway that plays a role in regulating both innate and adaptive immune responses. Although follistatin and activin A are constitutively produced in the pituitary, gonads and skin, their major source in the serum and their effects on neutrophils are poorly understood. Here we report a microfluidic model that includes both blood and lymphatic endothelial vessels, and neutrophils to investigate neutrophil-lymphatic trafficking during infection with P. aeruginosa. We found that lymphatic endothelial cells produce secreted factors that increase neutrophil migration toward P. aeruginosa, and are a significant source of both follistatin and activin A during Pseudomonas infection. We determined that follistatin produced by lymphatic endothelial cells inhibits activin A, resulting in increased neutrophil migration. These data suggest that the follistatin:activin A ratio influences neutrophil trafficking during infection with higher ratios increasing neutrophil migration.
Sex-, age-, and time-specific visual communication in brown bears
Authors: Penteriani Vincenzo , Etchart Léa , González-Bernardo Enrique , Hartasánchez Alfonso , Falcinelli Daniele , Ruiz‑Villar Héctor , Morales‑González Ana , Delgado María del Mar 
Published: February 2023

AbstractIntraspecific communication in mammals is well-documented but generally restricted to chemical and acoustic signaling. However, other overlooked channels, such as visual signaling, may be used to communicate among conspecifics. Here, by using experimental manipulations together with camera traps on 13 brown bear (Ursus arctos) rubbing trees in the Cantabrian Mountains (northwestern Spain), we document detailed temporal patterns and behavioral aspects of a recently discovered novel communication channel for this species, visual signaling through the trunk debarking of focal trees. Video footage showed that visual marking is a sex-, age-, and time-specific means of communication in brown bears, being performed exclusively by adult males during the mating season (mainly April–June in the study area). Trunk debarking was always associated with chemical marking and was never an isolated behavior, suggesting that visual and chemical signals might be complementary. Visual and chemical marks may provide different information; for example, visual marks could be an indicator of individual size and, thus, the dominance status of adult males looking for mating opportunities. This is the first time that evidence is provided showing that visual signaling in a large carnivore is exclusive to a specific class of individuals (adult males) and linked to reproductive needs only. Bear visual signaling not only represents an advance in our comprehension of animal communication but may also serve to easily locate the mating areas of mammals, which are crucial for large carnivore species, such as the brown bear, that frequently need specific and urgent plans for conservation and management.
Living With Physical Health Conditions: A Systematic Review of Mindfulness-Based Interventions for Children, Adolescents, and Their Parents
Authors: Hughes Olivia , Shelton Katherine H , Penny Helen , Thompson Andrew R 
Published: February 2023

Abstract

Objectives
This systematic review aimed to identify and appraise studies investigating the efficacy of mindfulness-based interventions (MBIs) for improving depression, anxiety and parental stress in families affected by childhood physical illnesses, as well as feasibility and acceptability.

Methods
Embase, PsycINFO, Scopus, Medline, and PubMed were searched between February 2 and 17, 2021, and updated on August 5, 2022. Studies investigating MBIs with children and adolescents (&lt;18 years) with physical health conditions were included, and results are presented with narrative synthesis.

Results
Eighteen studies met eligibility criteria. Studies included children and adolescents with chronic pain, headaches, cancer, heart conditions, esophageal atresia, inflammatory bowel disease, and polycystic ovary syndrome. Most studies reported mindfulness was feasible and acceptable, although findings for different health conditions were mixed. Some studies encountered difficulties with attrition, resulting in findings being underpowered.

Conclusions
MBIs show promise for improving anxiety and depression in children with physical health conditions, but there is limited support for reducing stress in the family unit. A potential direction for future research might be the inclusion of parents. However, because of the heterogeneity of studies included in this review, findings must be cautiously interpreted.
Stress-induced deeper rooting introgression enhances wheat yield under terminal drought
Authors: Bacher Harel , Montagu Aviad , Herrmann Ittai , Walia Harkamal , Schwartz Nimrod , Peleg Zvi 
Published: February 2023

Abstract
Water scarcity is the primary environmental constraint affecting wheat growth and production and is increasingly exacerbated due to climatic fluctuation, which jeopardizes future food security. Most breeding efforts to improve wheat yields under drought have focused on above-ground traits. Root traits are closely associated with various drought adaptability mechanisms, but the genetic variation underlying these traits remains untapped, even though it holds tremendous potential for improving crop resilience. Here, we examined this potential by re-introducing ancestral alleles from wild emmer wheat (Triticum turgidum ssp. dicoccoides) and studied their impact on root architecture diversity under terminal drought stress. We applied an active sensing electrical resistivity tomography approach to compare a wild emmer introgression line (IL20) and its drought-sensitive recurrent parent (Svevo) under field conditions. IL20 exhibited greater root elongation under drought, which resulted in higher root water uptake from deeper soil layers. This advantage initiated at the pseudo-stem stage and increased during the transition to the reproductive stage. The increased water uptake promoted higher gas exchange rates and enhanced grain yield under drought. Overall, we show that this presumably ‘lost’ drought-induced mechanism of deeper rooting profile can serve as a breeding target to improve wheat productiveness under changing climate.
Dancing at the Hotel Adlon: Queer, Black, and Jewish Characters in Contemporary German Television
Authors: Gollance Sonia 
Published: February 2023

Abstract
This article discusses Das Adlon: Eine Familiensaga (Hotel Adlon: A Family Saga), a 2013 German miniseries about one of the most exclusive addresses in Germany’s capital. This miniseries about the quintessentially upper-class German location chooses to portray minority characters whose story arcs are developed through dance scenes that reveal the complexity of representing queer, Black, and Jewish characters in a miniseries designed for mass consumption. In this way, the miniseries and its dance scenes raise important questions about who belongs in Germany. I contend that the dance floor is an arena through which the miniseries Hotel Adlon and its characters negotiate changing notions of what it means to be German.
Maternal Tobacco Smoking During Pregnancy and Children’s Emotional and Behavioral Trajectories: The EDEN Mother–Child Birth Cohort Study
Authors: Bonello Kim , Gomajee Ramchandar , Ibanez Gladys , Martins Silvia , Keyes Katherine , Nakamura Aurélie , Lepeule Johanna , Strandberg-Larsen Katrine , Fekom Mathilde , Melchior Maria 
Published: February 2023

Abstract

Introduction
The nature of the relationship between maternal tobacco smoking during pregnancy and the occurrence of children’s behavioral problems is still a matter of controversy. We tested this association using data collected among a sample of pregnant women and their offspring followed up from birth to early adolescence (age 12 years), accounting for multiple parent, child, and family characteristics.

Aims and Methods
Data come from 1424 mother–child pairs participating in the Étude des Déterminants pré et post-natals précoces du développement psychomoteur et de la santé de l’ENfant mother–child cohort in France. Using repeated measures (3, 5.5, 8, and 11.5 years) of the mother-reported Strengths and Difficulties Questionnaire, we estimated trajectories of children’s emotional and behavioral difficulties. Two aspects of maternal smoking were studied: The timing (nonsmoker, smoking during the periconceptional period, or throughout pregnancy) and the level of use (cigarettes/day) during the first trimester of pregnancy. Robust Poisson regression models controlled for confounding factors including maternal mental health and socioeconomic characteristics using propensity scores with the overlap weighting technique.

Results
Contrary to bivariate analyses, in propensity score–controlled regression models, maternal smoking throughout pregnancy was no longer significantly associated with offspring emotional or behavioral difficulties. Maternal heavy smoking (≥10 cigarettes/day) remained significantly associated with intermediate levels of conduct problems (RR 1.25, 95% CI 1.19 to 1.31).

Conclusions
The association between maternal smoking in pregnancy and offspring’s emotional and behavioral difficulties appears to be largely explained by women’s other characteristics. However, maternal heavy smoking appears to be related to offspring behavioral difficulties beyond the role of confounding characteristics.

Implications
The relationship between maternal smoking during pregnancy (in two modalities: Timing and level of smoking) and behavioral difficulties in children is still a matter of debate. While the relationship between any maternal tobacco use and offspring behavioral difficulties appears to be largely explained by confounding factors, heavy maternal smoking in the first trimester of pregnancy seems to be associated with offspring behavioral difficulties beyond the socioeconomic and mental health characteristics transmitted across generations.