bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMBEBANAN NAFKAH IDDAH DAN MUT’AH PADA PERKARA CERAI GUGAT DENGAN PUTUSAN VERSTEK (Analisis Putusan PA. Sei Rampah No: 991/Pdt.G/2022/PA.Srh)
Authors: Ramadi Bagus , Ramadi Bagus 
Published: February 2023

<p>Divorce is the breaking up of a legal relationship, also known as talak. In Islamic civil law literature (fiqh) in Indonesia, divorce can be filed by the husband (cerai talak) and divorce can also be filed by the wife (cerai gugat). The divorce proposed by the husband in the fiqh literature is called talak, while it is called the divorce proposed by the khuluk wife (ransom divorce) with the wife's obligation to pay 'iwadh. Between divorce by way of talak and divorce by way of khuluk husband or ex-husband has different obligations as regulated in the Compilation of Islamic Law. This study was conducted to find out the judge's legal considerations regarding the imposition of Iddah and mut'ah living expenses in divorce cases with verstek decisions and their relevance to the imposition of Iddah and mut'ah living expenses in litigation divorce cases. 991/PDT.G/2022/PA.Srh. in terms of the Compilation of Islamic Law. This research is a qualitative research with an empirical juridical approach. The primary data in this study is the decision of the Sei Rampah Religious Court No. 991/PDT.G/2022/PA and secondary data in this study include the Marriage Law, the Compilation of Islamic Law, books, journals and relevant previous research. The data analysis method of this research is descriptive analytical with a deductive pattern. The data collection instrument is the document study method on the decision no. 991/PDT.G/2022/PA.Srh. and interviews. The results showed that the judge's main considerations based on SEMA No. 3 of 2018 concerning the implementation of the formulation of the results of the 2018 Supreme Court Chamber Plenary Meeting as a Guide to the Implementation of Duties for the Court. The legal formulation of the Religious Chamber stated that the wife in a divorce case can be given mut'ah and 'iddah maintenance as long as it is not proven nusyuz.</p><p> </p><p> </p><p>Keywords: <em>Iddah, Mut'ah, Divorce, Verstek Decision</em></p>
In the Midst of the COVID-19 Pandemic, Politeknik Negeri Media Kreatif Used Flat Design Techniques as Educational Animation Media Material
Authors: Saharja Komda , Suhendra Suhendra 
Published: February 2023

The more innovation creates, the more inventive, seriously intriguing, and more imaginative limited time media, remembering special media for the type of movement illustrations. Politeknik Negeri Media Kreatif (Polimedia) Medan grounds is the object of exploration. The exploration utilizes a writing concentrate on research strategy, perception of Polimedia, which is a Vocational College as a substance reference. As a professional school, its reverberation isn't apparent at the degree of North Sumatra, a successful limited time media to the local area, particularly amidst the Covid-19 pandemic, Polimedia should focus on instructive media content that is appealing to its partners. The motivation behind this review is to deliver movement illustrations activity video media as instructive liveliness media content with level plan procedures with the objective of secondary school/professional youth who will proceed with their schooling to a more explicit level as indicated by proficient interests. The phases of the exploration strategy incorporate writing study, meetings to discover the means of Polimedia in presenting its grounds and dispersing polls to the plan target. Phases of creation include: pre-creation, creation, and after creation. In light of the exploration in the field, it reasoned that the pre-creation stage is the idea of typography and storyboard plan. At the phase of the creation cycle, to be specific Character Building (Drawing), Modeling, Facility Design, Animation and Post-Production Processes including Altering, audio cues, delivering, dominating, distributing recordings
Factors Associated with Participation in a Multidomain Web-Based Dementia Prevention Trial: Evidence from Maintain Your Brain (MYB)
Authors: Welberry Heidi J. , Chau Tiffany , Heffernan Megan , San Jose Juan Carlo , Jorm Louisa R. , Singh Maria Fiatarone , Sachdev Perminder S. , Anstey Kaarin J. , Lautenschlager Nicola T. , Valenzuela Michael , McNeil John J. , Brodaty Henry 
Published: February 2023

Background: The Maintain Your Brain (MYB) trial aims to prevent cognitive decline and dementia through multidomain, web-based risk-reduction. To facilitate translation, it is important to understand drivers of participation. Objective: To describe characteristics associated with participation in MYB. Methods: This was an observational ancillary study of MYB, a randomized controlled trial nested within the 45 and Up Study in New South Wales, Australia. We linked 45 and Up Study survey and MYB participation data. The study cohort comprised 45 and Up Study participants, aged 55–77 years at 1 January 2018, who were invited to participate in MYB. 45 and Up Study participant characteristics and subsequent MYB consent and participation were examined. Results: Of 98,836 invited, 13,882 (14%) consented to participate and 6,190 participated (6%). Adjusting for age and sex, a wide range of factors were related to participation. Higher educational attainment had the strongest relationship with increased MYB participation (university versus school non-completion; AdjOR = 5.15; 95% CI:4.70–5.64) and lower self-rated quality of life with reduced participation (Poor versus Excellent: AdjOR = 0.19; 95% CI:0.11–0.32). A family history of Alzheimer’s disease was related to increased participation but most other dementia risk factors such as diabetes, obesity, stroke, high blood pressure, and current smoking were associated with reduced participation. Conclusion: Higher socio-economic status, particularly educational attainment, is strongly associated with engagement in online dementia prevention research. Increasing population awareness of dementia risk factors, and better understanding the participation barriers in at-risk groups, is necessary to ensure online interventions are optimally designed to promote maximum participation.
Associations of Neurodegeneration Biomarkers in Cerebrospinal Fluid with Markers of Alzheimer’s Disease and Vascular Pathology
Authors: Shir Dror , Mielke Michelle M. , Hofrenning Ekaterina I. , Lesnick Timothy G. , Knopman David S. , Petersen Ronald C. , Jack Clifford R. , Algeciras-Schimnich Alicia , Vemuri Prashanthi , Graff-Radford Jonathan 
Published: February 2023

Background: The National Institute on Aging-Alzheimer’s Association Research Framework proposes defining Alzheimer’s disease by grouping imaging and fluid biomarkers by their respective pathologic processes. The AT(N) structure proposes several neurodegenerative fluid biomarkers (N) including total tau (t-tau), neurogranin (Ng), and neurofilament light chain (NfL). However, pathologic drivers influencing each biomarker remain unclear. Objective: To determine whether cerebrospinal fluid (CSF)-neurodegenerative biomarkers (N) map differentially to Alzheimer’s disease pathology measured by Aβ42 (an indicator of amyloidosis, [A]), p-tau (an indicator of tau deposition, [T]), and MRI vascular pathology indicators (measured by white-matter integrity, infarcts, and microbleeds [V]). Methods: Participants were from Mayo Clinic Study of Aging (MCSA) with CSF measures of NfL, Ng, t-tau, Aβ42, and p-tau and available MRI brain imaging. Linear models assessed associations between CSF neurodegeneration (N) markers, amyloid markers (A), tau (T), and vascular pathology (V). Results: Participants ( n = 408) had a mean age of 69.2±10.7; male, 217 (53.2%); cognitively unimpaired, 359 (88%). All three neurodegeneration biomarkers correlated with age ( p < 0.001 for NfL and t-tau, p = 0.018 for Ng). Men had higher CSF-NfL levels; women had higher Ng ( p < 0.001). NfL and t-tau levels correlated with infarcts ( p = 0.009, p = 0.034 respectively); no biomarkers correlated with white-matter integrity. N biomarkers correlated with p-tau levels (T, p < 0.001). Higher Aβ42 levels associated with higher N-biomarker levels but only among cognitively unimpaired (A, p < 0.001). Conclusion: The influence of vascular pathology in the general population on CSF (N) biomarkers is modest, with greater influence of infarcts than white-matter disruption. Neurodegeneration markers more closely correlated with tau than amyloid markers.
Associations of Lung Function Decline with Risks of Cognitive Impairment and Dementia: A Meta-Analysis and Systematic Review
Authors: Li Qiong-Yao , Li Xue-Mei , Hu He-Ying , Ma Ya-Hui , Ou Ya-Nan , Wang An-Yi , Tan Lan , Yu Jin-Tai 
Published: February 2023

Background: There are controversies surrounding the effects of lung function decline on cognitive impairment and dementia. Objective: We conducted a meta-analysis and systematic review to explore the associations of lung function decline with the risks of cognitive impairment and dementia. Methods: The PubMed, EMBASE, and the Cochrane Library were searched to identify prospective studies published from database inception through January 10, 2023. We pooled relative risk (RR) and 95% confidence intervals (CI) using random-effects models. The Egger test, funnel plots, meta-regression, sensitivity, and subgroup analyses were conducted to detect publication bias and investigate the source of heterogeneity. Results: Thirty-three articles with a total of 8,816,992 participants were subjected to meta-analysis. Poorer pulmonary function was associated with an increased risk of dementia (FEV: RR = 1.25 [95% CI, 1.17–1.33]; FVC: RR = 1.40 [95% CI, 1.16–1.69]; PEF: RR = 1.84 [95% CI, 1.37–2.46]). The results of the subgroup analyses were similar to the primary results. Individuals with lung diseases had a higher combined risk of dementia and cognitive impairment (RR = 1.39 [95% CI, 1.20–1.61]). Lung disease conferred an elevated risk of cognitive impairment (RR = 1.37 [95% CI, 1.14–1.65]). The relationship between lung disease and an increased risk of dementia was only shown in total study participants (RR = 1.32 [95% CI, 1.11–1.57]), but not in the participants with Alzheimer’s disease (RR = 1.39 [95% CI, 1.00–1.93]) or vascular dementia (RR = 2.11 [95% CI, 0.57–7.83]). Conclusion: Lung function decline was significantly associated with higher risks of cognitive impairment and dementia. These findings might provide implications for the prevention of cognitive disorders and the promotion of brain health.
Case Identification and Characterization of Migrants with Dementia in the Lazio Region Using Health Administrative Data
Authors: Cascini Silvia , Canevelli Marco , Agabiti Nera , Angelici Laura , Davoli Marina , Bacigalupo Ilaria , Cova Ilaria , Vanacore Nicola , Pomati Simone , Pantoni Leonardo , Acampora Anna , Bargagli Anna Maria ,   ImmiDem Study Group, Ancidoni Antonio , Bacigalupo Ilaria , Bellomo Guido , Canevelli Marco , Giusti Angela , Lacorte Eleonora , Palazzesi Ilaria , Piscopo Paola , Porrello Mariacristina , Sciancalepore Francesco , Vanacore Nicola , Zambri Francesca , Salvi Emanuela , Acampora Anna , Agabiti Nera , Angelici Laura , Bargagli Anna Maria , Cascini Silvia , Davoli Marina , Cova Ilaria , Maestri Giorgia , Nicotra Alessia , Pantoni Leonardo , Pomati Simone , Bruno Giuseppe , Zaccaria Valerio , Remoli Giulia , Valletta Martina , Di Blasio Norina , De Fiore Luca , Visco Caterina 
Published: February 2023

Background: A crucial step for planning effective public health policies for migrants with dementia is the collection of data on the local dimensions of the phenomenon and patients’ characteristics. Objective: This study aimed to identify and characterize migrants with dementia in the Lazio region using health administrative databases. Methods: Residents with dementia aged 50 years or older, living in the Lazio region as of December 31, 2018, were identified using a validated algorithm based on hospital discharge(s), claims for antidementia drugs, and co-payment exemption for dementia. Migrants were defined as people born abroad and grouped in migrants from High Migratory Pressure Countries (HMPCs) and Highly Developed Countries (HDCs). Overall and age-specific prevalence rates were estimated in native- and foreign-born patients. Results: Dementia was ascertained in 38,460 residents. Among them, 37,280 (96.9%) were born in Italy, 337 (0.9%) were migrants from HDCs, and 843 (2.2%) from HMPCs. Dementia prevalence was higher among natives (1.15%, 95% CI 1.14–1.16) relative to migrants from HDCs (0.60%, 95% CI 0.54–0.67) and HMPCs (0.29%, 95% CI 0.27–0.31). The prevalence of comorbidities did not differ between groups. Migrants with dementia had a lower likelihood of receiving antidementia treatments compared with natives (51.6% in migrants from HDCs, 49.3% in migrants from HMPCs, and 53.5% among Italians). Conclusion: Routinely collected data in healthcare administrative databases can support the identification of migrants with dementia. Migrants exhibited a lower age-standardized prevalence of registered dementia and lower access to dedicated treatments than Italians. These findings are suggestive of underdiagnosis and undertreatment of dementia in migrants.
Implementasi E-Marketing Kelompok Budidaya Trigona Batu Katak
Authors: Yuliana Yayuk , Falahi Adrial , Safina Wan Dian , Harahap Nur’ain 
Published: February 2023

Perusahaan kecil dewasa ini dikenal dengan sebuatan industri kreatif merupakan kegiatan ekonomi yang masih terus menerus diperhatikan oleh banyak pihak, karena sektor ini dipandang sebagai sektor yang dapat memberikan kontribusi yang luar biasa bagi negara dalam menangani pengangguran dan pemerataan distribusi pendapatan. Penyebaran virus corona (Covid-19) memukul perekonomian Indonesia, termasuk pelaku usaha. Pemasaran merupakan elemen penting menjalankan sebuah bisnis. Pelaku bisnis yang meluangkan waktunya untuk memikirkan metode pemasaran apa yang tepat agar barang yang dijualnya laku di pasaran karena sukses tidaknya bisnis bergantung pada metode atau cara pemasaran apa dan bagaimana yang dilakukan oleh pelaku usaha khususnya para pelaku UMKM. Minimnya pengetahuan tentang pemasaran secara on line menyebabkan pemasaran terbatas jangkauannya. Pemasaran yang dilakukan usaha Trigona batu katak masih sebatas pemasaran off line. Penelitian ini bertujuan untuk mengkaji dan menganalisis digital marketing di tengah Pandemi Covid 19 sebagai pertahanan ekonomi. Metode penelitian yang dilakukan adalah kualitatif deskriptif. Tujuan dari penelitian deskriptif dengan pendekatan kualitatif adalah untuk memperoleh gambaran implementasi e-marketing pada usaha Trigona Batu Katak. Pengumpulan data dilakukan dengan wawancara dan observasi kepada Ketua Kelompok Budidaya Trigona Batu Katak dan Penyuluh Kehutanan Taman Nasional Gunung Leuser. Hasil penelitian menunjukkan memanfaatkan digital marketing membantu Usaha Trigona Batu Katak dalam menginformasikan dan berinteraksi secara langsung dengan konsumen yaitu melalui sosial media faccebook dan Wasthsap. Dengan Pemasaran e-marketing diharapkan jangkauan pemasaran semakin luas dan pendapatan masyarakat dusun Batu Katak meningkat seiring ditutupnya ekowisata pada pertengahan maret 2020 akibat pandemi Covid 19.
Detection of selenoprotein transcriptome in chondrocytes of patients with Kashin–Beck disease
Authors: Gong Yi , Wu Yifan , Liu Yanli , Chen Sijie , Zhang Feiyu , Chen Feihong , Wang Chaowei , Li Shujin , Hu Minhan , Huang Ruitian , Xu Ke , Wang Xi , Yang Lei , Ning Yujie , Li Cheng , Zhou Rong , Guo Xiong 
Published: February 2023

Background: Kashin–Beck disease (KBD) is a deformed osteochondral disease with a chronic progression that is restrictively distributed in eastern Siberia, North Korea, and some areas of China, and selenium deficiency has been identified as an important factor in the pathogenesis of this disease in recent years.Objective: The aim of this study is to investigate the selenoprotein transcriptome in chondrocytes and define the contribution of selenoprotein to KBD pathogenesis.Methods: Three cartilage samples were collected from the lateral tibial plateau of adult KBD patients and normal controls paired by age and sex for real-time quantitative polymerase chain reaction (RT-qPCR) to detect the mRNA expression of 25 selenoprotein genes in chondrocytes. Six other samples were collected from adult KBD patients and normal controls. In addition, immunohistochemistry was used on four adolescent KBD samples and seven normal controls (IHC) to determine the expression of proteins screened by RT-qPCR results that had different gene levels.Results: Increased mRNA expression of GPX1 and GPX3 was observed in chondrocytes, and stronger positive staining was displayed in the cartilage from both adult and adolescent patients. The mRNA levels of DIO1, DIO2, and DIO3 were increased in KBD chondrocytes; however, the percentage of positive staining decreased in the KBD cartilage of adults.Conclusion: The selenoprotein transcriptome, mainly the glutathione peroxidase (GPX) and deiodinase (DIO) families were altered in KBD and might play a vital role in the pathogenesis of KBD.
Tamponade and massive pleural effusions secondary to peripherally inserted central catheter in neonates–A complication to be aware of
Authors: Zareef Rana , Anka Mariam , Hatab Taha , El Rassi Issam , Yunis Khalid , Bitar Fadi , Arabi Mariam 
Published: February 2023

BackgroundPeripherally inserted central catheters (PICC) are frequently used in neonatal intensive care units (NICU) to assist premature and critically ill neonates. Massive pleural effusions, pericardial effusions, and cardiac tamponade secondary to PICC are extremely uncommon but have potentially fatal consequences.ObjectiveThis study investigates the incidence of tamponade, large pleural, and pericardial effusions secondary to peripherally inserted central catheters in a neonatal intensive care unit at a tertiary care center over a 10-year period. It explores possible etiologies behind such complications and suggests preventative measures.Study designRetrospective analysis of neonates who were admitted to the NICU at the AUBMC between January 2010 and January 2020, and who required insertion of PICC. Neonates who developed tamponade, large pleural, or pericardial effusions secondary to PICC insertion were investigated.ResultsFour neonates developed significant life-threatening effusions. Urgent pericardiocentesis and chest tube placement were required in two and one patients, respectively. No fatalities were encountered.ConclusionThe abrupt onset of hemodynamic instability without an obvious cause in any neonate with PICC in situ should raise suspicion of pleural or pericardial effusions. Timely diagnosis through bedside ultrasound, and prompt aggressive intervention are critical.
Differences in protein expression, at the basal state and at 2 h of insulin infusion, in muscle biopsies from healthy Arab men with high or low insulin sensitivity measured by hyperinsulinemic euglycemic clamp
Authors: Bettahi Ilham , Krishnankutty Roopesh , Jaganjac Morana , Suleiman Noor Nabeel M. , Ramanjaneya Manjunath , Jerobin Jayakumar , Hassoun Shaimaa , Alkasem Meis , Abdelhakam Ibrahem , Iskandarani Ahmad , Samra Tareq A. , Mohamed-Ali Vidya , Abou-Samra Abdul Badi 
Published: February 2023

BackgroundSkeletal muscle is the main site for insulin-dependent glucose disposal. The hyperinsulinemic euglycemic clamp (HIEC) is the gold standard for the assessment of insulin sensitivity (IS). We have previously shown that insulin sensitivity, measured by HIEC, varied widely among a group of 60 young healthy men with normoglycemia. The aim of this study was to correlate the proteomic profile of skeletal muscles to insulin sensitivity.MethodsMuscle biopsies from 16 subjects having the highest (M ≥ 13; n = 8, HIS) and lowest (M ¾ 6, n = 8, LIS) IS were obtained at baseline and during insulin infusion after stabilization of the blood glucose level and glucose infusion rate at the end of the HIEC. The samples were processed using a quantitative proteomic analysis approach.ResultsAt baseline, 924 proteins were identified in the HIS and LIS groups. Among the 924 proteins detected in both groups, three were suppressed and three were increased significantly in the LIS subjects compared with the HIS subjects. Following insulin infusion, 835 proteins were detected in both groups. Among the 835 proteins, two showed differential responsiveness to insulin; ATP5F1 protein was decreased, and MYLK2 was higher in the LIS group compared with that in the HIS group. Our data suggest that alteration in mitochondrial proteins and an increased number of proteins involved in fast-twitch fiber correlate to insulin sensitivity in healthy young Arab men.ConclusionsThese results suggest a change in a small number of differentially expressed proteins. A possible reason for this small change could be our study cohorts representing a homogeneous and healthy population. Additionally, we show differences in protein levels from skeletal muscle in low and high insulin sensitivity groups. Therefore, these differences may represent early events for the development of insulin resistance, pre-diabetes, and type 2 diabetes.
Regular physical activity moderates the adverse impact of type 2 diabetes on brain atrophy independently from HbA1c
Authors: Moreno Carolina , d’Almeida Otília C. , Gomes Leonor , Paiva Isabel , Castelo-Branco Miguel 
Published: February 2023

ObjectiveBrain atrophy has been consistently associated with type 2 diabetes, beginning in early stages of dysglycemia, independently from micro and macrovascular complications. On the contrary, physical activity relates with larger brain volumes. Our aim is to assess the influence of regular physical activity on brain volumes in people with type 2 diabetes.MethodsA cross-sectional multimodal evaluation with 3T MRI was performed on 170 individuals: 85 individuals with type 2 diabetes and 85 controls. They underwent clinical examination, blood sampling and 3T MRI. Brain volumes (mm3) were estimated using FreeSurfer 7. Physical activity duration was self-reported by the participants as the number of hours of physical activity per week for at least the previous 6 months. Statistical analysis was performed with IBM SPSS 27.ResultsPeople with type 2 diabetes had significantly lower cortical and subcortical volumes, adjusted for age and individual intracranial volume, comparing to controls. Regression analysis showed that within type 2 diabetes group, lower gray matter volumes were associated with lesser physical activity duration (hours/week), independently from HbA1c. Moreover, there were significant moderate positive correlations between regular physical activity duration and gray matter volumes of cortical and subcortical subregions, specifically in the diabetes group.ConclusionsThis study reveals a putative beneficial effect of regular physical activity independently of glycemic control, as assessed by HbA1c, which might contribute to reduce the negative impact of type 2 diabetes in the brain.