bluuebunny/crossref_metadata_2025_split huggingface dataset:
A qualitative exploration of stakeholder perspectives on the implementation of a whole school approach to mental health and emotional well-being in Wales
Authors: Brown R , Van Godwin J , Edwards A , Burdon M , Moore G 
Published: January 2023

Abstract
Early intervention to support mental health and well-being of school-aged children may be of significant benefit in preventing escalation of mental health problems in later life. While there are limitations to current understanding of the best ways for schools to support mental well-being, a whole school approach (WSA), involving all those who are part of the school system in creating and sustaining a supportive environment where health is prioritized, may be effective. This research explored stakeholder views of this approach, as part of a contract commissioned by the Welsh Government to conduct an evaluability assessment of a WSA. Semistructured focus groups and interviews were completed with stakeholders from the health and education sectors, as well as parents, to explore how a WSA may operate in a Welsh context and barriers and facilitators to potential implementation and outcomes. Findings suggest that existing pressures on schools may impact implementation of a WSA, with school staff already time poor and many staff experiencing their own mental well-being challenges. Implementation may be supported by clear guidance at local and national levels, funding for staff time and training and stakeholder involvement at all stages. Long-term monitoring and evaluation are also needed to understand system changes.
SCN1A: bioinformatically informed revised boundaries for promoter and enhancer regions
Authors: Pagni Susanna , Custodio Helena Martins , Frankish Adam , Mudge Jonathan M , Mills James D , Sisodiya Sanjay M 
Published: January 2023

Abstract
Pathogenic variations in the sodium voltage-gated channel alpha subunit 1 (SCN1A) gene are responsible for multiple epilepsy phenotypes, including Dravet syndrome, febrile seizures (FS) and genetic epilepsy with FS plus. Phenotypic heterogeneity is a hallmark of SCN1A-related epilepsies, the causes of which are yet to be clarified. Genetic variation in the non-coding regulatory regions of SCN1A could be one potential causal factor. However, a comprehensive understanding of the SCN1A regulatory landscape is currently lacking. Here, we summarized the current state of knowledge of SCN1A regulation, providing details on its promoter and enhancer regions. We then integrated currently available data on SCN1A promoters by extracting information related to the SCN1A locus from genome-wide repositories and clearly defined the promoter and enhancer regions of SCN1A. Further, we explored the cellular specificity of differential SCN1A promoter usage. We also reviewed and integrated the available human brain-derived enhancer databases and mouse-derived data to provide a comprehensive computationally developed summary of SCN1A brain-active enhancers. By querying genome-wide data repositories, extracting SCN1A-specific data and integrating the different types of independent evidence, we created a comprehensive catalogue that better defines the regulatory landscape of SCN1A, which could be used to explore the role of SCN1A regulatory regions in disease.
Is evidence of effectiveness a driver for clinical decision support selection? A qualitative descriptive study of senior hospital staff
Authors: Baysari Melissa T , Van Dort Bethany A , Stanceski Kristian , Hargreaves Andrew , Zheng Wu Yi , Moran Maria , Day Richard , Li Ling , Westbrook Johanna , Hilmer Sarah 
Published: January 2023

AbstractLimited research has focused on understanding if and how evidence of health information technology (HIT) effectiveness drives the selection and implementation of technologies in practice. This study aimed to explore the views of senior hospital staff on the role evidence plays in the selection and implementation of HIT, with a particular focus on clinical decision support (CDS) alerts in electronic medication management systems. A qualitative descriptive design was used. Twenty senior hospital staff from six Australian hospitals in New South Wales and Queensland took part in a semistructured interview. Interviews were audio-recorded and transcribed, and a general inductive content analysis approach was used to identify themes. Participants acknowledged the importance of an evidence base, but reported that selection of CDS alerts, and HIT more broadly, was rarely underpinned by evidence that technologies improve patient care. Instead, investments in technologies were guided by the expectation that benefits will be achieved, bolstered by vendor assurances, and a perception that implementation of HIT is unavoidable. Postponing implementation of a technology until an evidence base is available was not always feasible. Although some technologies were seen as not requiring an evidence base, stakeholders viewed evidence as extremely valuable for informing decisions about selection of CDS alerts. In the absence of evidence, evaluation or monitoring of technologies postimplementation is critical, particularly to identify new errors or risks associated with HIT implementation and use. Increased transparency from vendors, with technology evaluation outcomes made directly available to healthcare organizations, may result in less reliance on logic, intuition, and vendor assertions and more evidence-based selection of HIT.
Implementing a screening algorithm for early recognition of sepsis in hospitalized children: a quality improvement project
Authors: Feinstein Yael , Kogan Slava , Dreiher Jacob , Noham Ayelet , Harosh Shimrat , Lecht Jenia , Sror Tzipi , Cohen Nurit , Bar-Yosef Eileen , Hershkowitz Eli , Lazar Isaac , Schonmann Yochai , Greenberg David , Danino Dana 
Published: January 2023

AbstractSepsis is a leading cause of mortality in children. Utilizing a screening tool for early recognition of sepsis is recommended. Our centre had no screening tool for sepsis nor a standardized protocol for sepsis management. In December 2020, a screening algorithm for sepsis was implemented. The algorithm consisted of vital signs measurements in children with an abnormal body temperature, a pop-up alert, nurse’s and physician’s evaluation, and activation of a workup protocol. The project’s primary aim was to increase vital signs measurement rates in hospitalized children with abnormal body temperature from 40% to &gt;90% within 6 months, by 1 June 2021, and sustain until 31 December 2021. Adherence to the algorithm and performance were monitored during 2021, and the outcomes were compared to the preceding 5 years and a control ward. The alert identified 324 children and 596 febrile episodes. Vital signs measurement adherence increased from 42.7% to &gt;90% in 2 months. A nurse evaluated 86.4% of episodes, and a physician evaluated 83.0% of these. Paediatric intensive care unit (PICU) admission rates were lower in the intervention period vs. the pre-intervention period vs. the control ward (4.6% vs. 5.6% vs. 6.0%, respectively); the median PICU length of stay was shorter in the intervention vs. the control ward [2.0 (IQR 1, 4) vs. 5.5 (IQR 2, 7), respectively]. These differences were not statistically significant. During the intervention period, the adherence to vital signs measurements reached the goal of &gt;90%. The alert system prompted an evaluation by caregivers and management according to the protocol. Further monitoring is needed to improve outcomes.
Sequential Sampling Plans for Thrips (Thysanoptera: Thripidae) in Soybean Crops With Insecticide Applications Using Tractor or Airplane
Authors: Neves Daniel Victor Chaves , Lopes Mayara Cristina , Pereira Poliana Silvestre , Reis Kayo Heberth de Brito , Picanço Mayara Moledo , Costa Thiago Leandro , Peluzio Joenes Mucci , Sarmento Renato Almeida , Picanço Marcelo Coutinho 
Published: January 2023

Abstract
Sampling plans are an essential part of integrated pest management programs. Sequential sampling plans enable rapid and low-cost assessment of pest densities. Thrips are emerging pests in soybean crops, and the main method used in pest control is chemical. In soybean crops, insecticides are applied mainly using tractors or airplanes. Thus, this work aimed to determine sequential sampling plans for thrips in soybean crops with insecticide applications using a tractor or airplane. Data were collected in 56 soybean fields, and each field was 20 ha. Sampling plans were determined and validated. The lower (m0) and upper (m1) limits of the sequential sampling plans were: m0 = 1.72 and m1 = 3.43 (by tractor applications) and, m0 = 2.27 and m1 = 4.53 thrips. sample−1 (by airplane applications). The slope (S) and the lower (h0) and upper (h1) intercepts of the sequential sampling plans were: S = 2.42, h0 = −5.79, and h1 = 5.79 (by tractor applications) and, S = 3.19, h0 = −6.83, and h1 = 6.83 (by airplane applications). Sequential sampling plans allowed for correct decisions to be made in all situations using a maximum of 10 samples. The sequential plan reduced the sampling effort by over 87% compared to conventional sampling plans. Therefore, these control decision-making systems have proven feasible and advantageous for implementing integrated pest management programs for controlling thrips species in soybean crops.
Neuropathology of microbleeds in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
Authors: Magaki Shino , Chen Zesheng , Severance Alyscia , Williams Christopher K , Diaz Ramiro , Fang Chuo , Khanlou Negar , Yong William H , Paganini-Hill Annlia , Kalaria Rajesh N , Vinters Harry V , Fisher Mark 
Published: January 2023

Abstract
Cerebral microbleeds (CMBs) detected on magnetic resonance imaging are common in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The neuropathologic correlates of CMBs are unclear. In this study, we characterized findings relevant to CMBs in autopsy brain tissue of 8 patients with genetically confirmed CADASIL and 10 controls within the age range of the CADASIL patients by assessing the distribution and extent of hemosiderin/iron deposits including perivascular hemosiderin leakage (PVH), capillary hemosiderin deposits, and parenchymal iron deposits (PID) in the frontal cortex and white matter, basal ganglia and cerebellum. We also characterized infarcts, vessel wall thickening, and severity of vascular smooth muscle cell degeneration. CADASIL subjects had a significant increase in hemosiderin/iron deposits compared with controls. This increase was principally seen with PID. Hemosiderin/iron deposits were seen in the majority of CADASIL subjects in all brain areas. PVH was most pronounced in the frontal white matter and basal ganglia around small to medium sized arterioles, with no predilection for the vicinity of vessels with severe vascular changes or infarcts. CADASIL subjects have increased brain hemosiderin/iron deposits but these do not occur in a periarteriolar distribution. Pathogenesis of these lesions remains uncertain.
Cell wall fucosylation in Arabidopsis influences control of leaf water loss and alters stomatal development and mechanical properties
Authors: Panter Paige E , Seifert Jacob , Dale Maeve , Pridgeon Ashley J , Hulme Rachel , Ramsay Nathan , Contera Sonia , Knight Heather 
Published: January 2023

AbstractThe Arabidopsis sensitive-to-freezing8 (sfr8) mutant exhibits reduced cell wall (CW) fucose levels and compromised freezing tolerance. To examine whether CW fucosylation also affects the response to desiccation, we tested the effect of leaf excision in sfr8 and the allelic mutant mur1-1. Leaf water loss was strikingly higher than in the wild type in these, but not other, fucosylation mutants. We hypothesized that reduced fucosylation in guard cell (GC) walls might limit stomatal closure through altering mechanical properties. Multifrequency atomic force microscopy (AFM) measurements revealed a reduced elastic modulus (Eʹ), representing reduced stiffness, in sfr8 GC walls. Interestingly, however, we discovered a compensatory mechanism whereby a concomitant reduction in the storage modulus (Eʹʹ) maintained a wild-type viscoelastic time response (tau) in sfr8. Stomata in intact leaf discs of sfr8 responded normally to a closure stimulus, abscisic acid, suggesting that the time response may relate more to closure properties than stiffness does. sfr8 stomatal pore complexes were larger than those of the wild type, and GCs lacked a fully developed cuticular ledge, both potential contributors to the greater leaf water loss in sfr8. We present data that indicate that fucosylation-dependent dimerization of the CW pectic domain rhamnogalacturonan-II may be essential for normal cuticular ledge development and leaf water retention.
Glutathione-mediated thermomorphogenesis and heat stress responses in Arabidopsis thaliana
Authors: Dard Avilien , Weiss Alizée , Bariat Laetitia , Auverlot Juline , Fontaine Valentine , Picault Nathalie , Pontvianne Frédéric , Riondet Christophe , Reichheld Jean-Philippe 
Published: January 2023

Abstract
In the context of climate change, the global rise of temperature and intense heat waves affect plant development and productivity. Among the molecular perturbations that high temperature induces in living cells is the accumulation of reactive oxygen species (ROS), which perturbs the cellular redox state. In plants, the dynamics of the cellular and subcellular redox state have been poorly investigated under high temperature. Glutathione plays a major role in maintaining the cellular redox state. We investigated its contribution in adaptation of Arabidopsis thaliana to contrasting high temperature regimes: high ambient temperature inducing thermomorphogenesis and heat stress affecting plant viability. Using the genetically encoded redox marker roGFP2, we show that high temperature regimes lead to cytoplasmic and nuclear oxidation and impact the glutathione pool. This pool is restored within a few hours, which probably contributes to plant adaptation to high temperatures. Moreover, low glutathione mutants fail to adapt to heat stress and to induce thermomorphogenesis, suggesting that glutathione is involved in both heat adaptation mechanisms. We also evaluate the transcriptomic signature in the two high temperature regimes and identified gene expression deviations in low glutathione mutants, which might contribute to their sensitivity to high temperature. Thus, we define glutathione as a major player in the adaptation of Arabidopsis to contrasting high temperature regimes.
Fluoride and gallein inhibit polyphosphate accumulation by oral pathogen Rothia dentocariosa
Authors: Kumar Dhiraj , Mandal Subhrangshu , Bailey Jake V , Flood Beverly E , Jones Robert S 
Published: January 2023

Abstract
The uptake and storage of extracellular orthophosphate (Pi) by polyphosphate (polyP) accumulating bacteria may contribute to mineral dissolution in the oral cavity. To test the effect of potential inhibitors of polyP kinases on Rothia dentocariosa, gallein (0, 25, 50, and 100 μM) and fluoride (0, 50, and 100 ppm) were added to R. dentocariosa cultures grown in brain-heart infusion broth. At a late log growth phase (8 h), extracellular Pi was measured using an ascorbic acid assay, and polyP was isolated from bacterial cells treated with RNA/DNAases using a neutral phenol/chloroform extraction. Extracts were hydrolyzed and quantified as above. Gallein and fluoride had minor effects on bacterial growth with NaF having a direct effect on media pH. Gallein (≥25 μM) and fluoride (≥50 ppm) attenuated the bacterial drawdown of extracellular Pi by 56.7% (P &lt; 0.05) and 37.3% (P &lt; 0.01). There was a corresponding polyP synthesis decrease of 73.2% (P &lt; 0.0001) from gallein and 83.1% (P &lt; 0.0001) from fluoride. Attenuated total reflectance-Fourier-transform infrared spectroscopy validated the presence of polyP and its reduced concentration in R. dentocariosa bacterial cells following gallein and fluoride treatment. Rothia dentocariosa can directly change extracellular Pi and accumulate intracellular polyP, but the mechanism is attenuated by gallein and NaF.
A unified logical framework for explanations in classifier systems
Authors: Liu Xinghan , Lorini Emiliano 
Published: January 2023

AbstractRecent years have witnessed a renewed interest in the explanation of classifier systems in the field of explainable AI (XAI). The standard approach is based on propositional logic. We present a modal language which supports reasoning about binary input classifiers and their properties. We study a family of classifier models, axiomatize it as two proof systems regarding the cardinality of the language and show completeness of our axiomatics. Moreover, we show that the satisfiability checking problem for our modal language is NEXPTIME-complete in the infinite-variable case, while it becomes polynomial in the finite-variable case. We moreover identify an interesting NP fragment of our language in the infinite-variable case. We leverage the language to formalize counterfactual conditional as well as a variety of notions of explanation including abductive, contrastive and counterfactual explanations and biases. Finally, we present two extensions of our language: a dynamic extension by the notion of assignment enabling classifier change and an epistemic extension in which the classifier’s uncertainty about the actual input can be represented.
A unified catalogue-level reanalysis of stage-III cosmic shear surveys
Authors: Longley Emily P , Chang Chihway , Walter Christopher W , Zuntz Joe , Ishak Mustapha , Mandelbaum Rachel , Miyatake Hironao , Nicola Andrina , Pedersen Eske M , Pereira Maria E S , Prat Judit , Sánchez J , Secco Lucas F , Tröster Tilman , Troxel Michael , Wright Angus H ,   The LSST Dark Energy Science Collaboration
Published: January 2023

ABSTRACT
Cosmological parameter constraints from recent galaxy imaging surveys are reaching percent-level accuracy on the effective amplitude of the lensing signal, S8. The upcoming Legacy Survey of Space and Time (LSST) of the Vera C. Rubin Observatory will produce subpercent level measurements of cosmological parameters, providing a milestone test of the ΛCDM model. To supply guidance to the upcoming LSST analysis, it is important to understand thoroughly the results from different recent galaxy imaging surveys and assess their consistencies. In this work, we perform a unified catalogue-level reanalysis of three cosmic shear data sets: the first year data from the Dark Energy Survey (DES-Y1), the 1000 deg2 data set from the Kilo-Degree Survey (KiDS-1000), and the first year data from the Hyper Suprime-Cam Subaru Strategic Program (HSC-Y1). We utilize a pipeline developed and rigorously tested by the LSST Dark Energy Science Collaboration to perform the reanalysis and assess the robustness of the results to analysis choices. We find the S8 constraint to be robust to two different small-scale modelling approaches, and varying choices of cosmological priors. Our unified analysis allows the consistency of the surveys to be rigorously tested, and we find the three surveys to be statistically consistent. Due to the partially overlapping footprint, we model the cross-covariance between KiDS-1000 and HSC-Y1 approximately when combining all three data sets, resulting in a 1.6–1.9 per cent constraint on S8 given different assumptions on the cross-covariance.
Anomalous compressible mode generation by global frame projections of pure Alfven mode
Authors: Yuen Ka Ho , Yan Huirong , Lazarian Alex 
Published: January 2023

ABSTRACTAlfven wave is the single most important physical phenomenon of magneto-hydrodynamic (MHD) turbulence and has far-reaching impact to almost all studies related to astrophysical magnetic field. Yet the restoration of the Alfven wave fluctuations from a given magnetic field, aka the local Alfven wave problem, is never properly addressed in literature albeit its importance. Previous works model the Alfven wave fluctuation as the perturbation along a straight-line, constant magnetic field. However, Lazarian & Pogosyan (2012) suggested that the decomposition of Alfven wave along a straight line, aka. the global frame decomposition, has a factor of discrepancy to the true local Alfven wave fluctuation. Here, we provide a geometric interpretation on how the local Alfven wave is related to the global frame through the use of vector frame formulation. We prove both analytically and numerically that the local frame Alfven wave is an orthogonal transformation of that of the global frame and related by the local Alfvenic Mach number. In other words, when we observe Alfven wave in the global frame of reference, some of the Alfven wave will be mistaken as compressible waves. The importance of frame choices has a far-reaching impact to the analytical studies of MHD turbulence. Combining the frame formalism and the new techniques we can have accurate measurement to some of the fundamental turbulence properties like the inclination angle of mean magnetic field relative to the line of sight.
The SCUBA-2 Large eXtragalactic Survey: 850μm map, catalogue and the bright-end number counts of theXMM-LSS field
Authors: Garratt T K , Geach J E , Tamura Y , Coppin K E K , Franco M , Ao Y , Chen C -C , Cheng C , Clements D L , Dai Y S , Dannerbauer H , Greve T R , Hatsukade B , Hwang H S , Jiang L , Kohno K , Koprowski M P , Michałowski M J , Sawicki M , Scott D , Shim H , Takeuchi T T , Wang W -H , Xue Y Q , Yang C 
Published: January 2023

ABSTRACTWe present $850\, \mu {\rm m}$ imaging of the XMM-LSS field observed for 170 h as part of the James Clerk Maxwell Telescope SCUBA-2 Large eXtragalactic Survey (S2LXS). S2LXS XMM-LSS maps an area of $9\, {\rm deg}^2$, reaching a moderate depth of $1\sigma \simeq 4\, {\rm mJy\, beam^{-1}}$. This is the largest contiguous area of extragalactic sky mapped by James Clerk Maxwell Telescope (JCMT) at $850\, \mu {\rm m}$ to date. The wide area of the S2LXS XMM-LSS survey allows us to probe the ultra-bright ($S_{\rm 850\mu m}\gtrsim 15\, {\rm mJy}$), yet rare submillimetre population. We present the S2LXS XMM-LSS catalogue, which comprises 40 sources detected at &gt;5σ significance, with deboosted flux densities in the range of $7$–$48\, {\rm mJy}$. We robustly measure the bright-end of the $850\, \mu {\rm m}$ number counts at flux densities ${\gt }7\, {\rm mJy}$, reducing the Poisson errors compared to existing measurements. The S2LXS XMM-LSS observed number counts show the characteristic upturn at bright fluxes, expected to be motivated by local sources of submillimetre emission and high-redshift strongly lensed galaxies. We find that the observed $850\, \mu {\rm m}$ number counts are best reproduced by model predictions that include either strong lensing or source blending from a 15-arcsec beam, indicating that both may make an important contribution to the observed overabundance of bright single dish $850\, \mu {\rm m}$ selected sources. We make the S2LXS XMM-LSS $850\, \mu {\rm m}$ map and &gt;5σ catalogue presented here publicly available.