bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plugged-in Electric Vehicle-Assisted Demand Response Strategy for Residential Energy Management
Authors: Alfaverh Khaldoon , Alfaverh Fayiz , Szamel Laszlo 
Published: January 2023

Abstract
Demand response (DR) management systems are a potentially growing market due to their ability to maximize energy savings by allowing customers to manage their energy consumption at times of peak demand in response to financial incentives from the electricity supplier. Successful execution of a demand response program requires an effective management system where the home energy management system (HEMS) is a promising solution nowadays. HEMS is developed to manage energy use in households and to conduct the management of energy supply, either from the grid or the alternative energy sources like solar or wind power plants. With the increase of vehicle electrification, in order to achieve a more reliable and efficient smart grid (SG), cooperation between electric vehicles (EVs) and residential systems is required. This cooperation could involve not only vehicle to grid (V2G) operation but a vehicle to home (V2H) too. V2H operation is used to transfer the power and relevant data between EVs and residential systems. This paper provides an efficient HEMS enhanced by smart scheduling and an optimally designed charging and discharging strategy for plugged-in electric vehicles (PEVs). The proposed design uses a fuzzy logic controller (FLC) for smart scheduling and to take the charging (from the grid)/discharging (supply the household appliances) decision without compromising the driving needs. Simulations are presented to demonstrate how the proposed strategies can help to reduce electricity costs by 19.28% and 14.27% with 30% and 80% state of charge (SOC) of the PEV respectively compared to the case where G2V operation only used along with the photovoltaic (PV) production, improve energy utilization by smoothing the energy consumption profile and satisfy the user’s needs by ensuring enough EV battery SOC for each planned trip.
Adaptive Estimation of Measurement Error in Chemiresistive Sensors and Its Correlation with Sensitivity
Authors: Sharma Alfa , Sharma Akash , Yadav Subhash Chand , Acharya Achyuta Nanda , Shirage Parasharam M. 
Published: January 2023

Abstract
We study the correspondence between sensitivity and adsorption/desorption induced hysteresis in ZnSnO3 resistive sensors. The ZnSnO3 humidity sensor made at 100°C present lower degree of error (1.21±0.12 %RH) associated with sensitivity of 0.11±0.01 kΩ(%RH)-1 whereas the 500°C annealed analogous showed an increased degree of measurement error value (1.48±0.23% RH) along with sensitivity of 0.14±0.02 kΩ(%RH)-1 within the humidity range of 8-97% RH. A proportionate increase in sensitivity and measurement error is evident with increase in annealing temperature. The principal component analysis (PCA) shows the migration of measurement errors from high to low RH level subject to annealing of sensing material. The trade-off relation between sensitivity and measurement error is observed for sensors with enactment of annealing emphasizes the prominence of revising the adsorption/desorption hysteresis as an crucial feature in development of metal oxide based chemiresistive sensors.
Prospective of early warning mapping in Flash flood mitigation and future planning in Marsa Alam, Egypt
Authors: Naggar Hadeel El 
Published: January 2023

Abstract
Most of the Arab region is at risk of natural disasters with significant economic, social, and environmental impacts. In Egypt, floods are a real threat to biological life and assets. Significant efforts must be made to overcome damages caused by floods, either on the country level or the regional one. This study will overview one of Egypt's tourist areas, Marsa Allam. It is considered an economic asset and tourism destination; therefore, it should be protected from flood risk. The study will demonstrate a flood mitigation, preparedness, and early warning project in Marsa Allam will be presented as one of the most critical stages to protect this area from the coming flood disasters.
Treatment and Outcome of Patients with Graves' Disease and Metastatic Differentiated Thyroid Cancer
Authors: Besic Nikola , Vidergar-Kralj Barbara 
Published: January 2023

Abstract

Background
There are only limited data in the literature about treatment of patients who have Graves' disease (GD) and metastatic thyroid cancer. The aim of our study was to report on our experience about the treatment and outcome of patients with Graves' disease and metastatic thyroid cancer in our country.
Methods
Altogether, 28 patients (eight males, 20 females; 49–85 years of age; median 74 years) were treated because of differentiated thyroid cancer and distant metastasis at the time of diagnosis during a 10-year period (from 2010 to 2019) in the Republic of Slovenia. The subject of our retrospective study were four patients (three men, one female; 64–76 years of age, median 73 years) who had Graves' disease and metastatic thyroid cancer. Papillary carcinoma, Hürthle cell carcinoma, follicular and poorly differentiated thyroid carcinoma were diagnosed in 13, six, five and four patients, respectively. Graves’ disease was present in two patients with Hürthle cell carcinoma, one with papillary and one with poorly differentiated thyroid carcinoma.
Results
The mean age of patients without GD and with GD was 74 years and 71 years, respectively (p = 0.36). There was a trend for male predominance in patients with GD (p = 0.06). There was no statistical difference in size of primary tumors (p = 0.36), pT stage (p = 0.52) or pN stage (p = 1.00) between the group of patients without GD and with GD. Patients received multimodal treatment (total thyroidectomy N = 18, neck dissection N = 4, preoperative chemotherapy N = 3, ablation of thyroid remnant with radioiodine N = 18, therapy with radioiodine N = 18, external beam radiotherapy of the neck region N = 7 patients, external beam radiotherapy of other localisations N = 6, targeted therapy N = 10). Three patients (1/3 with GD) received only palliative treatment. The median length of follow-up was 3.33 years (range 0.04–7.83) and 5-year disease-specific survival was 51%. One of four patients with GD and 14 of 24 patients without GD died of thyroid cancer. There was no statistical difference in disease-specific survival between patients group of without GD and with GD (p = 0.59).
Conclusion
In our country, 14% of patients with metastatic differentiated thyroid carcinoma at the time of diagnosis had Graves’ disease. There was no difference in the treatment, outcome or survival of patients with GD in comparison to those without GD.
Orientability through the algebraic multiplicity
Authors: Lopez-Gomez Julian , Sampedro Juan Carlos 
Published: January 2023

Abstract
This paper establishes some hidden connections between the theory of generalized algebraic multiplicities, $\chi$, and the notion of orientability of vector bundles. The novel approach adopted in it facilitates the definition of several invariants closely related to the first Stiefel--Whitney characteristic class through some path integration techniques.
Pressure-flow characteristics of a microchannel combining super- hydrophobicity and wall compliance
Authors: Amit Kumar , Assam Ashwani , Raj Abhishek 
Published: January 2023

Abstract
This paper reports a computational and theoretical investigation of pressure-flow characteristics of a microchannel having a superhydrophobic bottom wall with embedded air-cavities and, thin deformable membrane as the top wall. Two-way fluid-structure interaction (FSI) and unsteady volume of fluid (VOF) methods are employed for fluid-solid boundary and liquid-air interface at ridge-cavity, respectively. A novel theoretical model has been developed for the pressure-flow characteristics of microchannel with deformable top and superhydrophobic bottom wall. The theoretical and numerical results for pressure drop across the microchannel have shown a good agreement with a maximum deviation of 6.69%. Four distinct types of microchannels viz, smooth (S) (rigid non-textured), smooth with deformable top (SDT), smooth with superhydrophobic bottom (SSB) and, smooth with superhydrophobic bottom and deformable top wall (SSBT) have been investigated for the comparison of their pressure-flow characteristics. The Poiseuille Numbers (fRe) for SSBDT microchannel is found to be lowest with an average of 18.7% and maximum of 23.5% lower than S microchannel at 𝑅𝑒 = 60. Up to 48.59% of reduction in pressure drop was observed for the SSBDT microchannel as compared to smooth (S) microchannel of same dimensions. Further, critical Reynolds Number (Recritical) (at which the air-water interface breaks and super-hydrophobicity vanishes) was found to be ∼ 20% higher for SSBDT microchannel compared to SSB microchannel. Thus, the wall compliance in SSBDT microchannel is found to increase the capability to sustain the super-hydrophobicity at higher Re numbers.
Dose-dependent efficacy of bevacizumab in recurrent glioblastoma
Authors: Melhem Jawad M. , Tahir Ali , Calabrese Eirena , Granovskaya Inga , Atenafu Eshetu G. , Sahgal Arjun , Lim-Fat Mary Jane , Perry James R. 
Published: January 2023

Abstract
Background
Bevacizumab (BEV), at a standard dose of 10 mg/kg every 2 weeks is associated with prolonged progression-free survival (PFS) but no improvement in overall survival (OS) in recurrent glioblastoma (rGBM). Few studies have examined the potential dose-dependent efficacy of BEV. In Ontario, reimbursement for the costs of BEV varies, and as a result, our practice began to routinely use lower dose regimens. The main aim of this study was to ensure that there was no harm to patients who received the low dose protocol.
Methods
A single-center retrospective study of patients given BEV for rGBM between 2015–2020 was performed. Clinical and treatment data including BEV dose regimen (SD [10 mg/kg every 2 weeks] vs LD [5 mg/kg every 2–3 weeks or 10 mg/kg every 3 weeks]) received at the time of rGBM diagnosis were captured. Overall survival (OS) and progression-free survival (PFS) on BEV were compared using the Kaplan-Meier product-limit method. Log-rank test was used to compare potential predictive factors. Cox regression model was performed for multivariable analysis of OS and PFS.
Results
A total of 96 patients were included with a median follow-up duration of 6.84 months (range 1.12–50.63 months) from the date of the first infusion. The LD group consisted of 55 of the 96 patients. By virtue of funding mechanisms for BEV, the median age in the LD group was significantly higher (62 vs 54 years p = 0.009). There was no difference in MGMT status between the 2 groups (p = 0.60). Eight patients received lomustine with BEV (3 from the SD and 5 from the LD. The LD group had prolonged median PFS (5.89 months versus 3.22 months; p = 0.0112) and OS (10.23 months versus 6.28 months; p = 0.0010). Multivariable analysis including the dose of BEV, the extent of resection, gender, and age revealed that standard dose of BEV, subtotal resection, and female sex were associated with worse overall survival. Nine patients in the SD group vs 18 patients in the LD group reported an adverse event related to BEV.
Conclusions
For patients with recurrent GBM, we found that a low dose regimen of BEV was associated with prolonged OS and PFS compared to the standard dose regimen. Lower dose schedules may be a better and more cost-effective option for patients with rGBM. Lower costs might provide more equitable access to this very important palliative drug.
Has Invasive Amur Honeysuckle (Lonicera maackii (Rupr.) Maxim) Met its Match? Interspecies Comparisons of Photosynthesis and Shoot Allocation in Heavy Shade
Authors: Schulz Kurt E. 
Published: January 2023

Abstract
Amur honeysuckle (Lonicera maackii (Rupr.) Maxim) is a notorious invader of forests and forest edges throughout eastern North America. The species is difficult to exterminate and reestablishes readily. A perpetual presence of Amur honeysuckle in most forests is largely a forgone conclusion. Forests throughout the eastern U.S. are changing due to canopy closure after historical disturbance and long-term fire prevention. Fire intolerant species, especially sugar maple (Acer saccharum Marshall.), are coming to dominate forest canopies, creating shady understories and forest dynamics that pivot on shade tolerance. Two shade tolerant understory shrubs, pawpaw (Asimina triloba Adans.) and spicebush (Lindera benzoin Thunb.) compete with honeysuckle in maple understories. Based on field observations we hypothesized that these native species were more shade tolerant than invasive honeysuckle. We examined shade tolerance in honeysuckle, pawpaw, and spice bush by comparing photosynthetic light responses, leaf characteristics, and allocation to leaf area versus stem mass (leaf area ratio, LAR) in annual shoots. Honeysuckle had comparable light responses measured on a leaf area basis, but mass-based measurements show it is less efficient paying back carbon invested in leaf tissue. This arises because honeysuckle is unable to reduce specific leaf mass to the level of pawpaw and spicebush. LAR is distinctly higher in pawpaw and spicebush, suggesting an advantage in heavy shade. Since the great majority of photosynthesis in these species occurs under a closed canopy, we suggest honeysuckle will diminish in maple-dominated stands. Informal observations of greater height growth in pawpaw and spicebush in the field support this.
Deep learning synthesis of cone-beam computed tomography from zero echo time magnetic resonance imaging
Authors: Choi Hyeyeon , Yun Jong Pil , Lee Ari , Han Sang-Sun , Kim Sang Woo , Lee Chena 
Published: January 2023

Abstract
Cone-beam computed tomography (CBCT) produces high resolution of hard tissue even in small voxel size, but the process is associated with radiation exposure and poor soft tissue imaging. Thus, we synthesized a CBCT image from the magnetic resonance imaging (MRI), using deep learning and to assess its clinical accuracy. We collected patients who underwent both CBCT and MRI simultaneously in our institution. MRI data were registered with CBCT data, and both data were prepared into 512 slices of axial, sagittal, and coronal sections. A deep learning-based synthesis model was trained and the output data were evaluated by comparing the original and synthetic CBCT (syCBCT). According to expert evaluation, syCBCT images showed better performance in terms of artifacts and noise criteria but had poor resolution compared to the original CBCT images. In syCBCT, hard tissue showed better clarity with significantly different MAE and SSIM. This study result would be a basis for replacing CBCT with non-radiation imaging that would be helpful for patients planning to undergo both MRI and CBCT.
Deciphering the Sex Bias in Housekeeping Gene Expression in Adipose Tissue: a Comprehensive Meta-analysis of Transcriptomic Studies
Authors: Guaita-Cespedes Maria , Grillo-Risco Rubén , Hidalgo Marta R. , Fernández-Veledo Sonia , Burks Deborah Jane , Iglesia-Vayá María de la , Galán Amparo , Garcia Francisco Garcia 
Published: January 2023

Abstract
Background: As the housekeeping genes (HKG) generally involved in maintaining essential cell functions are typically assumed to exhibit constant expression levels across cell types, they are commonly employed as internal controls in gene expression studies. Nevertheless, HKG may vary gene expression profile according to different variables introducing systematic errors into experimental results. Sex bias can indeed affect expression display, however, up to date, sex has not been typically considered as a biological variable.
Methods: In this study, we evaluate the expression profiles of six classical housekeeping genes (four metabolic: GAPDH, HPRT, PPIA, and UBC, and two ribosomal: 18S and RPL19) to determine expression stability in adipose tissues (AT) of Homo sapiens and Mus musculus and check sex bias and their overall suitability as internal controls. We also assess the expression stability of all genes included in distinct whole-transcriptome microarrays available from the Gene Expression Omnibus database to identify sex-unbiased housekeeping genes (suHKG) suitable for use as internal controls. We perform a novel computational strategy based on meta-analysis techniques to identify any sexual dimorphisms in mRNA expression stability in AT and to properly validate potential candidates.
Results: Just above half of the considered studies informed properly about the sex of the human samples, however, not enough female mouse samples were found to be included in this analysis. We found differences in the HKG expression stability in humans between female and male samples, with females presenting greater instability. We propose a suHKG signature including experimentally validated classical HKG like PPIA and RPL19 and novel potential markers for human AT and discarding others like the extensively used 18S gene due to a sex-based variability display in adipose tissue. Orthologs have also been assayed and proposed for mouse WAT suHKG signature. All results generated during this study are readily available by accessingan open web resource (https://bioinfo.cipf.es/metafun-HKG) for consultation and reuse in further studies.
Conclusions: This sex-based research proves that certain classical housekeeping genes fail to function adequately as controls when analyzing human adipose tissue considering sex as a variable. We confirm RPL19 and PPIA suitability as sex-unbiased human and mouse housekeeping genes derived from sex-specific expression profiles, and propose new ones such as RPS8 and UBB.
Biliatresone and Biliary atresia – Disease modelling in C57BL/6J neonates
Authors: Schmidt Hans Christian , Hagens Johanna , Schuppert Pauline , Appl Birgit , Raluy Laia Pagerols , Trochimiuk Magdalena , Philippi Clara , Li Zhongwen , Reinshagen Konrad , Tomuschat Christian 
Published: January 2023

Abstract
Exposure to plant toxins or microbiota that are able to digest common food ingredients to toxic structures might be responsible for biliary atresia (BA). An isoflavonoid, biliatresone is known to effectively alter the extrahepatic bile duct (EHBD) development in BALB/c mice. Biliatresone causes a reduction of Glutathione (GSH) levels, SOX17 downregulation and is effectively countered with N-Acetyl-L-cysteine (NAC) treatment in vitro. Therefore, reversing GSH-loss appears to be a promising treatment target for a translational approach. Since BALB/c mice have been described as sensitive in various models, we evaluated the toxic effect of biliatresone in robust C57BL/6J mice and confirmed its toxicity. Comparison between BALB/c and C57BL/6J mice revealed similarity in the toxic model, indicating that the onset of BA induced by biliatresone is independent of the strain specific different immune systems. Affected neonates exhibited clinical symptoms of BA, such as jaundice, ascites, clay-colored stools, yellow urine and impaired weight gain. The gallbladders of jaundiced neonates were hydropic and EHBD were twisted and enlarged. Serum and histological analysis proved cholestasis. No anomalies were seen in the liver and EHBD of control animals. With our study we join a chain of evidence confirming the BA-inducing effect of biliatresone.
Correlation of plasma procalcitonin and C-reactive protein levels with disease severity in critically ill patients with mixed-pathogen bloodstream infections of both Enterococcus spp. and Candida spp.
Authors: Li Yan 
Published: January 2023

AbstractBackground:Antibiotic overuse and increase of rates of invasive treatments, the incidence of bloodstream infections (BSIs) caused by mixed-pathogens (fungi and bacteria) has been on the rise. This retrospective observational study investigated the clinical significance of inflammatory biomarkers in predicting prognosis of critically ill patients with mixed-BSIs due toEnterococcusspp. andCandidaspp.Methods:Patients who were admitted to intensive care unit (ICU) from January 2018 to December 2020 were included. Of the total 66 enrolled patients, 35 and 31 patients were assigned to mixed- (fungi and bacteria) and single- (bacteria only) pathogen BSI groups, respectively. On the one hand, we compared the diffferences in plasma procalcitonin (PCT) and C-reactive protein (CRP) levels and disease severity (including Acute Physiology and Chronic Health Evaluation [APACHE] II scores, ICU stay duration, and 30-day mortality) between these two groups. On the other hand, their correlations with disease severity were also analysed.Results:The plasma CRP levels in the mixed-pathogen BSI group was higher than that in the single-pathogen BSI group; the same trend was observed for the disease severity. In the Spearman’s rank correlation analysis, plasma CRP levels were positively correlated with disease severity in the mixed-pathogen BSI group. Further, plasma PCT levels were also positively correlated with APACHE II scores and ICU stay duration. In contrast, in the single-pathogen BSI group, plasma PCT levels were positively correlated with APACHE II scores only, whereas plasma CRP levels did not correlate positively with 30-day mortality.Conclusions:In summary, mixed-pathogen BSIs caused byEnterococcusspp. andCandidaspp. lead to higher plasma PCT and CRP levels in comparison to BSI caused byEnterococcusspp. only, thereby resulting in a higher disease severity in critically ill ICU admitted patients.
Compounds of natural origin as anti-protease in SARS-CoV-2 using combinatory In silico approaches
Authors: Dwivedi Manish , Vidya Sree , Yadav Shalini , Dubey Kshatresh Dutta 
Published: January 2023

Abstract
SARS-CoV-2 is one of the deadly outbreaks in the present era and still showing its presence around the globe. Researchers have demonstrated various vaccines till now which may provide only protection but the cure is not possible after infection and we are seeking for efficient therapeutic leads to cure this infectious disease. In the current work, we investigated the main protease (Mpro) protein in SARS-CoV-2 which is crucial during viral particle formation and further, proposed five compounds of plant origin with the therapeutic potential. The 1000 compounds were screened from various plant-based resources and further physiochemical characterization and assessment of drug likeliness of phytocompounds were performed using SwissADME. Eventually, we screened 95 compounds out of 1000 molecules based on docking analysis using AutoDock Vina. Five compounds were selected having the highest affinity for Mpro, followed by the analysis of interaction using molecular dynamic (MD) simulation. Docking and MD simulation studies elucidated the promising stable interaction of selected 5 ligands with Mpro. During MD simulation of 100ns, Abacopterin F showed the lowest binding energy (-37.13 kCal/mol) with the highest affinity towards Mpro and this compound may be proposed as lead molecule for further investigation which interact and modulate the activity of the Mpro required for viral particle formation. However, in-vitro and in-vivo experimental validation would be needed to process the selected phytomolecules as a therapeutic lead against SARS-CoV-2.