bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic variation and cluster analysis of Narcissus tazetta L. genotypes using RAPD and ISSR markers
Authors: ZABET Mohammad , ESMAEILZAEI Leyli , IZANLOO Ali , RAMAZANI Seyyed Hamid Reza 
Published: April 2023

To evaluate the genetic diversity of Iranian Narcissus genotypes (e.g., Shomal, Shastpar, Shahla, Yasuj, Shiraz-1, Shiraz-2, Kuchak-e-Atri, Dutch, Khosf-1, Khosf-2, Birjand, and Tabas), different RAPD and ISSR primers were examined at the Plant Breeding Laboratory of the Faculty of Agriculture, University of Birjand, Iran. In sum, RAPD and ISSR primers produced 189 and 80 high-resolution bands. The average values of PIC, Ht, Hs, Nm, DST, FDT, NA, Ne, H, and I indices were 0.287, 0.369, 0.089, 0.486, 0.279, 0.760, 1.952, 1.459, 0.282, 0.437 for RAPD markers and equal to 0.297, 0.380, 0.099, 0.524, 0.278, 0.732, 1.978, 1.495, 0.303, 0.467 for ISSR markers, respectively. The analysis of molecular variance based on the RAPD and ISSR markers showed 23 and 13 % variations for intra-populations and 77 % and 87 % changes for inter-population variabilities, respectively. Cluster analysis based on the RAPD and ISSR markers grouped genotypes into four clusters. Based on RAPD and ISSR markers, the PCoA analysis also showed that the first three components justified equal to 96.9 % and 97.9 % of the total variance, respectively, indicating the dispersion of the primers used. In general, it was concluded that the genetic diversity of narcissus species could be employed for breeding programs.
Preliminary assessment of genetic diversity between Glebionis coronaria and G. discolor (Asteraceae) by AFLP markers
Authors: GALLUCCI Alessia , MUSARELLA Carmelo Maria , CANO-ORTIZ Ana , PIÑAR FUENTES José Carlos , QUINTO CANAS Ricardo , Villano Clizia 
Published: April 2023

<p class="042abstractstekst"><em>Glebionis coronaria</em> is a valuable and medicinal herb native of Mediterranean region. Recently, <em>G. coronaria</em> var. <em>discolor</em> has been elevated to the rank of species as <em>G. discolor</em> (d’Urv.) Cano<em> </em>based on morphological characteristics, distinguishing it from <em>G. coronaria</em> var. <em>coronaria</em> (=<em>G. coronaria</em>). To investigate the genetic basis of this diversity, AFLP markers were applied to genotypes of <em>G. discolor</em> and <em>G. coronaria</em> sampled in three different Mediterranean regions (Italy, Spain, and Portugal). Our results showed that among 1347 fragments identified with five primer combinations 99.55 % were polymorphic. The genetic distance and the Shannon Index values suggested that the two species can be genetically distinguished, but further studies are needed to confirm this hypothesis.</p>
Radix puerariae in the treatment of diabetic nephropathy: A network pharmacology analysis and experimental validation
Authors: Li Cheng , Jiang Hongli , Yao Jingchun , Chen Xulong , Tian PuXun 
Published: April 2023

Abstract

Radix puerariae has become the most commonly used medicine for diabetic nephropathy (DN). However, the mechanism of Radix puerariae in the treatment of DN is not completely clear. This study is to determine the active ingredients, targets, and signaling pathways of Radix puerariae for the treatment of DN using network pharmacology analysis and animal experiments to confirm its possible mechanism of action. A total of 12 potential effective components and 10 key therapeutic targets were obtained. The Kyoto Encyclopedia of Genes and Genomes enrichment analysis indicated that the use of Radix puerariae in DN treatment mainly involves HIF-1 signaling pathway, TNF signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, FoxO signaling, and VEGF signaling pathway. Molecular docking proved that the combined activity of the components with potential key targets were excellent. Animal experiments showed that Radix puerariae could improve the renal pathological structure in DN rats. Radix puerariae could decrease the content of AKT1, IL-6, INS, and reduce the expression levels of p-Akt/Akt and p-FoxO1/FoxO1 in renal tissue of DN rats. This study provides insight into the therapeutic potential and molecular mechanisms of Radix puerariae for treating DN.
DC ground fault monitoring method of electrical equipment in 110 kV smart substation based on improved rough set
Authors: Sun Pei , Gao Jianyong , Li Xiang , Zhang Pingjuan , Yang Ke 
Published: April 2023

Abstract
In order to improve the effect and timeliness of ground fault monitoring and improve the effect of fault early warning, a DC ground fault monitoring method for electrical equipment in 110 kV smart substations based on improved rough sets is proposed. The characteristics of the DC ground fault current are analyzed, and the equivalent model of the DC system is constructed according to the analysis results. The low-frequency signal is enhanced according to the fuzzy rough set, and the low-frequency sampled transient zero-sequence current signal is enhanced preprocessing and wavelet packet decomposition according to the signal enhancement proportional coefficient, and the fault line is selected according to the principle of maximum energy. The wavelet packet transform method is used to decompose and analyze the waveform of the leakage current generated when a single-point grounding fault occurs in a branch of the DC system, and the grounding fault location of the DC system of the substation is realized by relative entropy operation. With the help of the cloud platform, a DC ground fault monitoring platform is built, and the ground fault monitoring is completed by using this platform. The experimental results show that the method can obtain the characteristic harmonics of the ground fault, accurately monitor whether the mutation occurs, and can realize the early warning of the ground fault of the electrical equipment in a faster time, indicating that it can realize the accurate and timely monitoring of the ground fault.
Changes in grit and psychological capital at the time of major crisis: nursing students’ perseverance, resources, and resilience
Authors: Terry Daniel , Peck Blake , Biangone Marianne 
Published: April 2023

Abstract

Objectives
To examine changes in grit and psychological capital among nursing students prior to, during the height of the pandemic, and more than 12 months after the initial pandemic announcement.

Methods
A cross-sectional study design addressed the aim of the study. Nursing students undertaking a three-year baccalaureate degree between 2019 and 2021 were included.

Results
Mean grit levels among the n=818 unique student participants were significantly lower in 2020 than in 2019 and 2021; however, no significant difference was detected for psychological capital over the same period.

Conclusions
Although normative day-to-day challenges may aid grit development, a major event has a negative impact yet has a buffering effect of negative life events at the time of a crisis. The study further placates that psychological capital remains malleable and open to change at the time of a crisis and may be an essential mechanism to mediate grit and has the capacity to influence student performance over time. It remains essential to develop grit through the mediating elements of psychological capital to enable nursing student to undertake academic studies, particularly in the event of major challenges, such approaches may further enable students’ endurance to withstand major crises as they enter the workforce.
Semi-analytical approximation of time-fractional telegraph equation via natural transform in Caputo derivative
Authors: Kapoor Mamta , Khosla Samanyu 
Published: April 2023

Abstract
In the present research study, time-fractional hyperbolic telegraph equations are solved iteratively using natural transform in one, two, and three dimensions. The fractional derivative is considered in the Caputo sense. These equations serve as a model for the wave theory process of signal processing and transmission of electric impulses. To evaluate the validity and effectiveness of the suggested strategy, a graphical comparison of approximated and exact findings is performed. Convergence analysis of the approximations utilising

L

∞

{L}_{\infty }

has been done using tables. The suggested approach may successfully and without errors solve a wide variety of ordinary differential equations, partial differential equations (PDEs), fractional PDEs, and fractional hyperbolic telegraph equations.
Compounded Bell-G class of statistical models with applications to COVID-19 and actuarial data
Authors: Alsadat Najwan , Imran Muhammad , Tahir Muhammad H. , Jamal Farrukh , Ahmad Hijaz , Elgarhy Mohammed 
Published: April 2023

Abstract
The compounded Bell generalized class of distributions is proposed in this article as an alternative to the compounded Poisson generalized family of distributions. Some properties and actuarial measures are presented. The properties of a special model named Bell Weibull (BellW) are obtained such as the linear representation of density, rth moment, incomplete moment, moment generating function using Wright generalized hypergeometric function and Meijer’s G function, the pth moment of order statistics, reliability, stochastic ordering, and residual and reversed residual life. Moreover, some commonly used entropy measures, namely, Rényi, Havrda and Charvat, and Arimoto and Tsallis entropy are obtained for the special model. From the inferential side, parameters are estimated using maximum likelihood estimation. The simulation study is performed to highlight the behavior of estimates. Some actuarial measures including expected shortfall, value at risk, tail value at risk, tail variance, and tail variance premium for the BellW model are presented with the numerical illustration. The usefulness of the proposed family is evaluated using insurance claims and COVID-19 datasets. Convincing results are obtained.
Assessment of medical waste generation rate in Viet Nam
Authors: Le Thai Ha , Do Phuong Hien , Nguyen Phuong Hang , Do Vu Khanh Huyen , Nguyen Thi Ha 
Published: April 2023

Abstract
This study was conducted to estimate medical wastes generation rates in Viet Nam. Within 3 years (from 2017 to 2019), total medical wastes generated daily of 1,737 health-care facilities at different levels from 19/63 provinces in Viet Nam were surveyed. The calculation was based on the median daily generation (in kg) of 6 medical waste groups and total actual patient beds in 9 health-care facility categories. Six medical waste groups were sharps, non-sharps, high-risk infectious, pathological, non-infectious hazardous, recyclable and non-recyclable wastes. Surveyed health-care facilities were categorized in central general hospitals, central specialist hospitals, provincial general hospitals, provincial specialist hospitals, district health centers, regional clinics, commune health stations, private hospitals and private clinics. The results showed that waste generation rates varied from 0.0009 to 1.619 kg/bed/day depends on type of medical wastes or health-care facilities.
For no-patient-bed facilities (commune health stations and private clinics), medical waste generation rates of these two were calculated in kg/day and varied from 0.1 to 1.75 kg/day.
Structure and Function of Neuronal Circuits Linking Ventrolateral Preoptic Nucleus and Lateral Hypothalamic Area
Authors: Prokofeva Kseniia , Saito Yuki C. , Niwa Yasutaka , Mizuno Seiya , Takahashi Satoru , Hirano Arisa , Sakurai Takeshi 
Published: April 2023

To understand how sleep-wakefulness cycles are regulated, it is essential to disentangle structural and functional relationships between the preoptic area (POA) and lateral hypothalamic area (LHA), since these regions play important yet opposing roles in the sleep-wakefulness regulation. GABA- and galanin (GAL)-producing neurons in the ventrolateral preoptic nucleus (VLPO) of the POA (VLPOGABAand VLPOGALneurons) are responsible for the maintenance of sleep, while the LHA contains orexin-producing neurons (orexin neurons) that are crucial for maintenance of wakefulness. Through the use of rabies virus-mediated neural tracing combined within situhybridization (ISH) in male and femaleorexin-iCremice, we revealed that the vesicular GABA transporter (Vgat, Slc32a1)- and galanin (Gal)-expressing neurons in the VLPO directly synapse with orexin neurons in the LHA. A majority (56.3 ± 8.1%) of all VLPO input neurons connecting to orexin neurons were double-positive forVgatandGal. Using projection-specific rabies virus-mediated tracing in male and femaleVgat-ires-CreandGal-Cremice, we discovered that VLPOGABAand VLPOGALneurons that send projections to the LHA received innervations from similarly distributed input neurons in many brain regions, with the POA and LHA being among the main upstream areas. Additionally, we found that acute optogenetic excitation of axons of VLPOGABAneurons, but not VLPOGALneurons, in the LHA of maleVgat-ires-Cremice induced wakefulness. This study deciphers the connectivity between the VLPO and LHA, provides a large-scale map of upstream neuronal populations of VLPO→LHA neurons, and reveals a previously uncovered function of the VLPOGABA→LHA pathway in the regulation of sleep and wakefulness.SIGNIFICANCE STATEMENTWe identified neurons in the ventrolateral preoptic nucleus (VLPO) that are positive for vesicular GABA transporter (Vgat) and/or galanin (Gal) and serve as presynaptic partners of orexin-producing neurons in the lateral hypothalamic area (LHA). We depicted monosynaptic input neurons of GABA- and galanin-producing neurons in the VLPO that send projections to the LHA throughout the entire brain. Their input neurons largely overlap, suggesting that they comprise a common neuronal population. However, acute excitatory optogenetic manipulation of the VLPOGABA→LHA pathway, but not the VLPOGAL→LHA pathway, evoked wakefulness. This study shows the connectivity of major components of the sleep/wake circuitry in the hypothalamus and unveils a previously unrecognized function of the VLPOGABA→LHA pathway in sleep-wakefulness regulation. Furthermore, we suggest the existence of subpopulations of VLPOGABAneurons that innervate LHA.
Planificación del uso de bicicletas en ciudades intermedias: propuesta de una red de ciclorrutas para Tunja, Colombia
Authors: Quintero González Julián Rodrigo 
Published: April 2023

La bicicleta ha tomado gran fuerza en todo el mundo como medio de transporte; sin embargo, aún se discute su implementación en ciudades intermedias. En la presente investigación se pretende conceptualizar una red de ciclorrutas para la ciudad de Tunja, Colombia, que es una típica ciudad intermedia. La metodología se orienta a la formulación de una red básica a partir de las características de la ciudad (vocación, movilidad, morfología y distribución espacial), así como criterios de planeación urbana. En consecuencia, se presentan la caracterización de la ciudad, el análisis de la movilidad, el concepto del trazado de la red de ciclorrutas, sus costos estimados e instrumentos de planificación y financiación. Se concluye sobre la necesidad de avanzar en la investigación que permita proyectar la red de ciclorrutas propuesta a un sistema de bicicletas compartidas en la ciudad[1].

[1] Este artículo presenta el resultado del trabajo de investigación desarrollado por el autor en el marco de las actividades del Grupo de Estudios e Investigación en Recursos Ambientales y Urbanos (RAU), encuadrado en la línea de investigación de “Transporte, Urbanismo y Movilidad”. Estuvo orientado al estudio y análisis de los sistemas y medios de transporte en las ciudades intermedias de Colombia y sus potencialidades de desarrollo.
La competitividad urbana pos covid-19. Ruta desde sus componentes: identidad e imagen
Authors: Ornes Vasquez Sandra 
Published: April 2023

Las ciudades son espacios de intercambio de bienes y servicios, donde ocurren procesos de riqueza e innovación, que no siempre se dan de forma equitativa y equilibrada. Por lo tanto, se incrementa la demanda de políticas acorde con la competitividad y con la sostenibilidad ambiental y social. La competitividad urba­na debe estar sustentada en atributos y capacidades para generar valor frente a las diferentes demandas de los actores locales, con incidencia en el mejoramiento integral de su calidad de vida.
Aun con lo anterior, ante el escenario de pandemia por el covid-19, las ciudades registraron las mayores cifras de contagio y propagación, y no estaban preparadas para asumir la amenaza sanitaria. Sus actividades comerciales, servicios y espacios públicos fueron afectados, por lo que se desdibujaron y replantearon elementos estructurantes de su competitividad, como su imagen e identidad urbana. Así pues, como una respuesta de adaptación ante la amenaza reinante, cambiaron las prioridades ciudadanas, sus condiciones de vida y sus formas de relacionarse con la urbe y de vincularse con los otros.
La emergencia sanitaria global que a la fecha (2022) aún está en curso, obligó a atender la “nueva realidad o normalidad” a partir del rescate y replanteamiento de los atributos urbanos y el fortalecimiento de las capacidades locales. Por ello, a continuación, se plantea una investigación cualitativa y exploratoria, de tipo documental, que utiliza el análisis de contenido, con el propósito de establecer una hoja de ruta hacia una estrategia de competitividad urbana post covid-19, que redimensione los elementos de la funcionalidad urbana desde el ejercicio de la planificación local.
Perfil clínico-epidemiológico e prevalência do escore Geriatric 8 alterado em idosos com câncer em tratamento antineoplásico sistêmico
Authors: Sgnaolin Valéria , Haygertt Mallmann Francielly , Herberto Schneider Rodolfo 
Published: April 2023

Introdução: os idosos representam uma população com características heterogêneas atuantes no processo saúde-doença. A escala Geriatric 8 representa uma ferramenta de triagem utilizada em idosos com câncer para identifi car indivíduos frágeis.Objetivo: descrever o perfi l clínico-epidemiológico e a prevalência do escore Geriatric 8 alterado em idosos com câncer em tratamento antineoplásico sistêmico. Método: estudo observacional, transversal em pacientes com idade ≥60 anos que realizaram tratamento antineoplásico sistêmico para tumores sólidos em dois hospitais terciários no período de maio a setembro de 2020.Resultados: foram incluídos 178 indivíduos com idade média de 70,8 ± 7,6 anos, sendo 57,1% do sexo feminino e 82,6% com alguma comorbidades. As principais neoplasias identifi cadas foram de pulmão (21,9%), de mama (15,7%) e colorretal (14,0%), variando conforme o sexo, e 72,5% apresentavam doença metastática. A prevalência de escore ≤ 14 pela escala Geriatric 8 foi de 66,9%.Conclusão: a caracterização do perfi l clínico-epidemiológico dos idosos com câncer de uma determinada população permite a identifi cação das variáveis que afetam direta e indiretamente o tratamento e a evolução das doenças neoplásicas. A elevada prevalência de escore alterado da escala Geriatric 8 demonstra a suscetibilidade da população estudada, sugerindo a necessidade do desenvolvimento de estratégias para melhorar o prognóstico e a qualidade de vida desses indivíduos.
Aerobics approach in Teaching Social Dance
Authors: Yashier T. Hadji Kasan , Bandraz D. Sugador 
Published: April 2023

Study purpose.The aim of this study was to find out the performance, acceptability and effectiveness of teaching social dance using an aerobics approach among students.
Materials and methods. In this study, quantitative research with a descriptive-evaluative and experimental research design (ERD) was used to determine the level of dance of cha-cha and samba social dances by two groups of participants (control and experimental groups). The researcher used a total enumeration of fourth-year and third-year students taking the Bachelor in Secondary Education major in MAPEH, using traditional and aerobics approaches. The aerobics approach was used to teach the experimental group, which included nonstop disco music in cha-cha-cha and samba as well as warm-up and cool-down exercises. The same social dance was taught to the control group, which used the traditional method of counting 8 sets of beats: 1, 2, 3, 4, 5, 6, 7, 8, 6, 5, 4, 3, 2, 1. Both the traditional and aerobic approaches were taught for 40 minutes each.
Results. The findings reveal significant differences in dance performance, acceptability, and effectiveness between the control group using a traditional approach and the experimental group using an aerobics approach.
Conclusions. Aerobics is recommended in teaching social dance to facilitate better learning because it allows students to learn at their own pace and according to their own interests and needs.
面向印尼中级汉语学习者的指人缀词研究
Authors: Sunarti S , Liying Zeng 
Published: April 2023

Abstract: This paper research the 10 personal’s Chinese semi-affixes such as “人, 鬼, 汉, 师, 家, 生, 手, 星, 员, 长, among the intermediate phase of the Chinese Department State University of Surabaya in Indonesia in the form of questionnaires. At the same time, the condition of Indonesian students personal’s semi-affixes in the Chinese language was analyzed. This paper finds that within 10 Chinese personal’s semi-affixes mentioned, Indonesian students in the intermediate phases have mastered the personal’s semi-affixes: “师”, “员”, and “长”and the intermediate Indonesian students find “鬼”, “家” and “星” were most difficult.
摘要: 本文以印度尼西亚泗水国立大学中文系中间阶段中的“人、鬼、汉、师、家、生、手、星、员、长”等10个指人词缀的形式进行研究。 同时，对印尼学生汉语个人半词缀的情况进行了分析。 本文发现，在提到的10个中文指人词缀中，中级阶段的印尼学生已经掌握了指人词缀：“师”、“员”、“长”。 印尼中级学生觉得“鬼”、“家”、“星”最难。
Effect of saroglitazar in South Indian patients with diabetic dyslipidemia uncontrolled on a moderate-intensity statin and the association of PPAR α and γ gene polymorphisms with its response
Authors: Bage Isaac J. , Kamalanathan Sadishkumar , Selvarajan Sandhiya , Sahoo Jayaprakash , Mathaiyan Jayanthi , Naik Dukhabandhu 
Published: April 2023

Background: Diabetic dyslipidemia is associated with atherosclerosis risk factors and cardiovascular disease. Saroglitazar is a dual PPAR α and γ agonist approved initially for diabetic dyslipidemia and later for managing non-alcoholic steatohepatitis and hyperglycemia in T2DM. This study was conducted to estimate the association of studied PPAR α and γ gene polymorphisms among patients with diabetic dyslipidemia at baseline and with triglyceride response to saroglitazar administration.
Methods: A total of 54 diabetic dyslipidemia patients who are not controlled i.e., triglycerides (TG)>200 mg/dl with moderate intensity of atorvastatin (≥10 mg) were recruited to the study. All the patients were given saroglitazar 4 mg once daily for 12 weeks. PPARα single nucleotide polymorphisms (SNPs) rs1800206, rs4253778, rs135542 and those of PPARγ gene rs3856806, rs10865710, rs1805192 were genotyped by real-time PCR.
Results: 54 patients (67% female) with a mean age of 48.01±6.73 years were given saroglitazar 4 mg once daily for 12 weeks. There was a significant decrease in TG (36.9%) from baseline of 292.33±83.81mg/dl (mean±SD) to 184.46±95.90 mg/dl (<0.001) and in HbA1c (0.66%) from baseline of 8.5% to 7.8% (<0.001). PPAR α and PPAR γ gene variants did not show any association with TG lowering response.
Conclusions: Saroglitazar 4mg once daily effectively decreases the TG, non-HDL-C levels, and HbA1c with no major adverse events, and TG lowering response is not associated with the studied polymorphisms.