bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Ionic Liquid in Sequential Trial‐Curable Off‐Stoichiometric Amine–Epoxy Thermosets on Curing Behavior, Thermal and Thermomechanical Properties
Authors: Dlugaj Anna M. , de Vita Corrado , Arrabiyeh Peter A. , May David 
Published: February 2025

ABSTRACTThe aim of this work was to develop and characterize sequential trial‐curable off‐stoichiometric thermosets based on two curing agents with different reactivities in terms of temperature. Trial‐curing refers to the occurrence of three curing reactions: epoxy‐amine polycondensation reaction triggered by polyetheramine D‐230 (reactive curing agent) at lower temperature, followed by adduct formation and anionic homopolymerization, both triggered by 1‐ethyl‐3‐methylimidazolium dicyanamide (latent curing agent) at higher temperature. Intermediate materials were studied after the first curing step. A wide range of properties such as reactivity, glass transition, network density, and thermal stability could be tuned by adjusting the relative contribution of the involved reactions. The glass transition of final samples, determined from the peak temperature of tan delta curve by Dynamic Mechanical Analysis, varied from 108.8°C to 166.4°C. This value increased by decreasing relative contribution of the epoxy‐amine condensation reaction. The curing process was additionally monitored by Fourier‐transformed infrared spectroscopy to identify curing reactions.
Morphology and function of pinniped necks: The long and short of it
Authors: Keller Justin , Berta Annalisa , Juhn Mark , Van Valkenburgh Blaire 
Published: February 2025

AbstractTerrestrial vertebrates from at least 30 distinct lineages in both extinct and extant clades have returned to aquatic environments. With these transitions came numerous morphological adaptations to accommodate life in water. Relatively little attention has been paid to the cervical region when tracking this transition. In fully aquatic cetaceans, the cervical vertebrae are compressed, largely because a loss of neck mobility reduces drag. We ask whether this pattern of cervical evolution is present in the more recently evolved semiaquatic pinnipeds. Here, we compare neck morphology and function in three families of pinnipeds, the Otariidae, Phocidae, and Odobenidae as well as between pinnipeds and their terrestrial arctoid relatives (ursids and mustelids). Using cranial CT scans, we quantified the occipital surface area for neck muscle attachment as well as vertebral size and shape using linear measurements. Results show that pinnipeds have a relatively larger occipital surface area than ursids and terrestrial mustelids, suggesting that marine carnivorans have enlarged their neck muscles to assist with head stabilization during swimming. Within pinnipeds, we found quantitative differences in cervical morphology between otariids and phocids that coincide with their locomotor style. Phocids are hindlimb‐dominated swimmers that propel themselves with pelvic oscillations. Their necks are relatively stiff and their cervical vertebrae are compressed anteroposteriorly with reduced muscular attachment areas. By contrast, otariids are forelimb‐dominated swimmers that locomote in water and on land using their pectoral limbs, often recruiting their neck to initiate turns underwater as well as assisting in “walking” on land. Consequently, otariids have stronger, more flexible necks than phocids, which is reflected in more elongate cervical vertebral centra with larger muscle attachments. The walrus (Odobenidae) has a cervical vertebrae morphology intermediate to that of phocids and otariids, consistent with a phocid swimming mode combined with a more muscular neck that likely functions in intraspecific conflict and haul‐out behavior.
Robustness and Related Concepts for Climate Adaptation in Drinking Water Treatment Systems
Authors: Nemani Kirti S. , Peldszus Sigrid , Huck Peter M. 
Published: February 2025

ABSTRACTClimate change intensifies extreme weather events, potentially posing significant challenges to the quality and quantity of surface water available for drinking water treatment. Quantifying and substantiating a treatment system's capacity and vulnerability in handling a range of raw water conditions is crucial for preparing for future climate scenarios. Concepts like resilience and reliability and related tools have been applied to drinking water treatment plants (DWTPs), but often fail to capture the operational boundaries of treatment processes. Robustness offers a complementary approach, focusing on the range of conditions a system can effectively manage, thereby laying the foundation for improving the system and thus bridging a critical gap in adaptation strategies. This review examines the interconnections between robustness, resilience, reliability, risk, and vulnerability, providing tailored definitions for DWTPs. It also introduces visual diagrams to further illustrate their link and collective role in climate adaptation planning.
The link between school leadership, staff job satisfaction and retention. Longitudinal evidence from England
Authors: Jerrim John 
Published: February 2025

AbstractThis paper presents new evidence on the link between staff perceptions of school leadership and job satisfaction, drawing on three waves of The Engagement Platform data collected from over 4000 members of school staff in England. We find that when staff have a positive rather than an ambivalent view of school leadership, their job satisfaction is markedly improved. Views of school leadership in the autumn term are also found to correlate with whether staff leave their job by the end of the academic year. Together, our results demonstrate how views of leadership play a pivotal role in the satisfaction and retention of school staff.
Software‐Oriented Collaborative Project‐Based Learning of Biomedical Signal Processing in Simulated Industry‐Like Conditions
Authors: Pieciak Tomasz , Augustyniak Piotr 
Published: February 2025

ABSTRACTMost academic approaches to teaching biomedical signal processing (BSP) focus either on acquisition procedures of electrophysiological data, predefined menu‐driven signal processing methods using virtual laboratories, or ordinary signal processing procedures applied to biomedical signals without reaching the nature of the data and reflecting the future workplace. This paper introduces a new software‐oriented project‐based learning approach to BSP for graduate biomedical engineering students. The course simulates industry‐like practices under an imposed work environment and acquaints the participants with biomedical signal evaluation and quality assurance (QA) procedures required for software standardization. The students develop fully functional multifaceted software to analyze real‐world electrocardiograms that can be run on a desktop computer without external numerical tools. The project is led by a project manager (PM) and assisted by a software architect (SA) and project coordinator (PC). The paper hypothesizes that learning the BSP through a proposed simulated industry‐like approach improves understanding of BSP principles, computer programming skills, and social competencies in developing a collaborative project. The results show that the participants significantly enriched BSP‐related knowledge after the course, improved computer programming skills (p < 0.0001; nonparametric Wilcoxon signed‐rank test), and enhanced soft skills in collaborative work (p < 0.001) and public presentations (p < 0.001). The course participants valued the role of algorithm prototyping stages and QA procedures according to official standardization rules. The PM and SA enabled the smooth software development process, while the PC has proven helpful in resolving intrinsic conflicts.
Comparison of Subjective and Objective Cognitive Function and Emotional State in Supratentorial Brain Tumors Before Surgery—Recognizing the Influence of Laterality
Authors: Schock Lisa , Wrede Karsten , Oezkan Neriman , Dammann Philipp , Oppong Marvin Darkwah , Gembruch Oliver , Jabbarli Ramazan , Kreitschmann‐Andermahr Ilonka , Siegel Sonja , Friedel Anna Lena , Engel Adrian , Karadachi Hanah Hadice , Laflör Lilith Philomena , Sure Ulrich , Ahmadipour Yahya 
Published: February 2025

ABSTRACTObjectiveBecause of its high prognostic value, neuropsychological assessment plays a crucial role in the neuro‐oncology setting. Subjective and objective cognitive performance correlate only to a limited extent, and subjective cognitive performance is strongly dependent on emotional state. We postulate that the relation of subjective and objective cognitive performance depends on tumor laterality.MethodsIn this prospective study, N = 63 patients with brain tumors underwent a neuropsychological test battery, including assessment of subjective cognitive function (attention, memory, executive), and symptoms of depression and anxiety before surgery. Patients with psychiatric comorbidity or severe neurological conditions were excluded.ResultsThere were no significant differences in subjective and objective cognitive function, symptoms of depression and anxiety between left (N = 37) and right (N = 26) hemisphere tumors. All measures of subjective cognitive function correlated highly significantly with symptoms of depression and anxiety in left hemisphere tumor patients (all r ≥ 0.470). In right hemisphere tumor patients, there was no relation between subjective cognitive function and emotional state. Significant laterality differences for correlations of subjective and objective cognitive function were not found and were not significant within the two groups.ConclusionsEven when unbiased by symptoms of anxiety and depression, right hemisphere tumor patients show the same discrepancy in subjective and objective cognitive function as left hemisphere tumor patients. This discrepancy may be based on a different mechanism in right hemisphere tumor patients.
The Package Says More Than a Thousand Words: The Effect of Eco‐Labelling and Package Material on Consumer's Purchase Intentions
Authors: Ollitervo Virpi , Sipilä Jenni , Terho Harri 
Published: February 2025

ABSTRACTThis study investigates the influence of two prominent visual packaging cues, eco‐labels, and packaging material, on consumers' green purchase intentions in the context of gift‐giving, which represents a more complex decision compared to routine consumption. We derive a novel theoretical framework based on signaling theory and cue utilization theory and test our hypotheses with three experiments. The findings reveal that eco‐labels and packaging material do not have an interactive effect on purchase intentions. However, an eco‐label can indirectly drive purchase intentions through the perceived environmental friendliness of the product (Studies 1, 2, 3). Furthermore, an environmentally friendly packaging material can indirectly affect purchase intentions through both perceived attractiveness of packaging (Studies 1, 2, 3) and perceived environmental friendliness of the product (Studies 1 and 3). The research extends the existing literature at the intersection of green consumption and packaging design by providing novel evidence of the theoretical mechanisms, through which visual packaging cues influence purchase intentions. Furthermore, the study makes a contribution by studying the effects in the previously overlooked context of gift‐giving. The implications of the findings are discussed in relation to green marketing and the prevention of greenwashing. Thus, this study provides valuable insights for academics, companies, and regulators interested in fostering green consumption.
Optimizing Device Selection in Percutaneous Paravalvular Leak Closure: A Comparative Study of Different Transthoracic and Transesophageal Echocardiographic Techniques
Authors: Tekin Meltem , Güler Gamze Babur , Çiçek Mehmet , Tanboğa İbrahim Halil , Pysz Piotr , Güler Arda , Demir Ali Rıza , Efe Yusuf , Atmaca Sezgin , Pay Dilara , Kalkan Ali Kemal , Ertürk Mehmet 
Published: February 2025

ABSTRACTBackgroundClinically significant paravalvular leak (PVL) may complicate both surgical and transcatheter valve implantation. Percutaneous PVL closure (PPVLC) is becoming an increasingly attractive alternative to redo surgery, with demonstrated lower mortality and morbidity rates. Echocardiographic techniques are crucial for accurate diagnosis, defect sizing, and determining the appropriate size of the sealing devices.AimsThere is no consensus on the optimal imaging modality for PVLs. We aimed to compare transthoracic and transesophageal echocardiographic measurements to accurately determine defect size and estimate device size.MethodsWe reviewed hospital records to identify patients diagnosed with moderate to severe and severe PVL from 2018 to 2024. A total of 81 patients who underwent PPVLC were evaluated. Eight of these patients were excluded due to unsuccessful PPVLC, leaving 73 patients who were successfully treated. The defect size for all patients was evaluated using 2D transthoracic echocardiography (TTE), 2D transesophageal echocardiography (TEE), direct 3D TEE cropped volume rendering vena contracta (VC) measurement, and 3D TEE multiplanar reconstruction (3D TEE MPR).ResultsAmong the 73 patients, 42 underwent aortic PPVLC and 31 underwent mitral PPVLC. Proportional odds logistic regression analysis identified 3D TEE MPR measurement as the strongest predictor of device size accuracy, both overall and within the aortic/mitral subgroups. In the mitral subgroup, the predictive power of direct 3D TEE cropped volume rendering VC measurement and 3D TEE MPR measurement were similar. Furthermore, a cut‐off value of 7 mm was identified for hemodynamically significant jets as measured by 3D methods.ConclusionOur findings suggest that using 3D TEE MPR significantly improves the accuracy of device size selection in both mitral and aortic PVL. Additionally, direct 3D TEE cropped volume rendering VC measurement can serve as a viable alternative for patients with mitral PVL.
A Rare Case of Atypical Pelvic Retroperitoneal Lipoma Mimicking Liposarcoma; A Case Report and Review of Literature
Authors: Forder Bea Harris , Nistor Sabina , Siddiqui Ather , Soleymani majd Hooman 
Published: February 2025

ABSTRACTRetroperitoneal lipomas are exceptionally rare tumors that mimic liposarcomas. We present a case of a woman in her 30s undergoing fertility investigations, with an incidental finding of a retroperitoneal tumor on MRI. PET and MRI scans suggested this may be a liposarcoma, with widespread effects on the surrounding iliac vessels. Collaboration between the orthopedic sarcoma service, gynecological oncology, and vascular surgery was required to excise the tumor without damaging the surrounding vessels. The patient underwent an exploratory midline laparotomy, with mobilization of the ascending colon along the Toldt line to gain access to the tumor. The morbid adherence of the tumor to neurovascular structures added significant complexity to this procedure; however, complete tumor resection was achieved with mobilization and excision of the obturator nerve only. The initial histological diagnosis was well‐differentiated liposarcoma; however, subsequent molecular analysis showed no evidence of MDM2 amplification, suggesting a final diagnosis of benign lipoma. This case exemplifies diagnostic challenges in lipomatous retroperitoneal tumors, as well as the importance of inter‐disciplinary collaboration in surgery to achieve the best surgical and oncological outcomes.
Myocardial Infarction Caused by Aortic Root Thrombus in a Patient With Antiphospholipid Syndrome
Authors: Ichihara Kazuki , Suzuki Masataka , Hashimura Hiromi , Eizawa Hiroshi 
Published: February 2025

ABSTRACTAortic root thrombosis is a rare but serious complication of antiphospholipid syndrome that can lead to myocardial infarction. Cardiac computed tomography and magnetic resonance imaging are essential for noninvasively evaluating myocardial infarction and aortic root thrombosis.
The Use of WALANT Technique in the Osteosynthesis of Ankle Fractures: A Clinical Case Video
Authors: Kastanis Grigorios , Chaniotakis Constantinos , Siligardou Mikela‐Rafaella , Stavrakakis Ioannis , Kapsetakis Petros 
Published: February 2025

ABSTRACTThe Wide‐Awake Local Anesthesia No Tourniquet (WALANT) technique enables the creation of a suitable surgical field without the need for a tourniquet, while also allowing for the evaluation of the ankle under physiological forces (active ankle movement) after fixation. Data on the use of the WALANT technique in open reduction and internal fixation of ankle fractures are limited. This case video is the first to be presented in the literature.
OXIDATION‐DEFORMYLATION CASCADE CATALYZED BY A MONONUCLEAR COPPER COMPLEX
Authors: Wang Yongxing , Gomez Pineiro Rogelio , Leblay Rébecca , Giorgi Michel , Bertaina Sylvain , Orio Maylis , Faure Bruno , Réglier Marius , Simaan A. Jalila 
Published: February 2025

In this study, two copper complexes were synthesized using N3 (arising from two pyridines and one amide group) containing ligands N‐(2‐picolyl)picolinamide (L1H) and bis(2‐pyridylcarbonyl)amine (L2H), forming [(L1)CuII(OH2)(NO3)] (1) and [(L2)CuII(OH2)2](NO3) (2). The reaction of complex 1 with hydrogen peroxide in alcoholic solvents yielded a formate‐bound complex. Studies with isotopically labeled 13C ethanol indicated that formate originates from the C1 of ethanol after C‐C bond cleavage. Complex 1 was found to catalytically convert primary alcohols into formic acid probably following a two‐step process: (i) alcohol oxidation to aldehyde and (ii) aldehyde deformylation. Further experiments with 2‐phenylpropionaldehyde (2‐PPA) confirm the ability of complex 1 to catalyze aldehyde deformylation. Both steps of the reaction are associated with significant kinetic deuterium isotope effects (KDIE), suggesting that hydrogen atom abstractions (HAA) occur during the rate‐determining steps of both conversions. Overall, this system proposes a clean catalytic process for alcohol‐to‐formic acid conversion, operating under mild conditions, and offering potential synthetic applications.
Treatment‐free remission in nontransplanted patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia
Authors: Kugler Eitan , Kantarjian Hagop , Jabbour Elias , Khaire Niranjan , Short Nicholas J. , Kadia Tapan M. , Haddad Fadi G. , Sasaki Koji , Kanagal Shamanna Rashmi , Garris Rebecca , Ravandi Farhad , Jain Nitin 
Published: February 2025

AbstractBackgroundThe BCR::ABL1 tyrosine kinase inhibitors (TKIs) have significantly improved the outcomes of patients with Philadelphia chromosome (Ph)‐positive acute lymphoblastic leukemia (ALL). However, the optimal duration of TKI therapy in patients who achieve a complete molecular response (CMR; undetectable BCR::ABL1 transcripts) and who do not undergo allogeneic stem cell transplantation (allo‐SCT) remains undefined.MethodsThe authors conducted a retrospective analysis of patients with Ph‐positive ALL in first complete remission who achieved a CMR and discontinued TKI therapy, most commonly due to treatment‐related side effects.ResultsIn total, 14 patients were identified. The regimen of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with high‐dose methotrexate and cytarabine was the primary backbone chemotherapy and was received by 12 patients (86%) combined with either imatinib (14%), dasatinib (43%), or ponatinib (29%) during induction. Two patients received blinatumomab and ponatinib. The median duration of TKI therapy was 60 months. The median CMR duration before TKI discontinuation was 46.1 months (range, 2.7–121.3 months). After a median follow‐up of 42.5 months from TKI discontinuation, three patients (21%) experienced relapse (two molecular, one morphologic), whereas 11 patients (79%) maintained treatment‐free remission. The median time to relapse was 6.4 months (range, 4–16 months), and two of three relapsed patients regained CMR after resuming TKI therapy. Importantly, none of the six patients with a CMR duration >48 months before TKI discontinuation relapsed.ConclusionsThe current findings suggest that TKI discontinuation may be safe for highly selected patients with Ph‐positive ALL in first complete remission who maintain CMR for at least 48 months. Larger studies are needed to confirm these findings.
Total Arch Replacement Versus Hemiarch Replacement in Hemodynamic Performance: A Simulation Study
Authors: Shi Yike , Zhang Chenjia , Zhao Yawei , Jin Yusheng , Li Fen , Song Hui , Chen Lingfeng , Zhang Hongpeng 
Published: February 2025

ABSTRACTAcute type A aortic dissection (ATAAD) is a life‐threatening aortic emergency with high mortality. Currently, hemiarch replacement (HAR) and total arch replacement (TAR) are the primary surgeries for ATAAD, but their long‐term outcomes remain debated, possibly due to the influence of clinical factors in multicenter studies. This study aims to evaluate the long‐term outcomes of HAR and TAR by in silico analysis, mitigating the impact of clinical factors. A personalized model was reconstructed to simulate HAR and TAR by altering the material properties at the replacement regions, obtaining hemodynamic and wall response parameters through two‐way fluid–structure interaction analysis. HAR exhibits a higher increase in von Mises stress at the anastomosis compared to pre‐operation levels (HAR: 4.39 times normal, TAR: 2.42 times normal), increasing the risk of pseudoaneurysm formation. TAR induced more severe streamline absence in the arch branches, potentially resulting in intermittent blood flow to the upper limbs and brain. HAR poses a higher risk of pseudoaneurysm formation at the anastomosis, while TAR carries increased risks of upper limb and cerebral ischemia. Enhanced monitoring of the anastomosis in HAR patients and vigilance for upper limb fatigue and cerebral ischemic events in TAR patients are recommended. This study offers effective guidance for managing postoperative HAR and TAR patients, contributing to the prevention of complications and enhancing their postoperative quality of life.