bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pilot study to identify pharmacogenomic and clinical risk factors associated with opioid related falls and adverse effects in older adults
Authors: Sheikh Sophia , Fernandez Rosemarie , Smotherman Carmen , Brailsford Jennifer , Langaee Taimour , Velasquez Esteban , Henson Morgan , Munson Taylor , Bertrand Andrew , Hendry Phyllis , Anton Stephen , Fillingim Roger B. , Cavallari Larisa H. 
Published: September 2023

AbstractGiven the high prevalence of pain in older adults and current trends in opioid prescribing, inclusion of genetic information in risk prediction tools may improve opioid risk assessment. Our objectives were to (1) determine the feasibility of recruiting socioeconomically disadvantaged and racially diverse middle aged and older adult populations for a study seeking to identify risk factors for opioid‐related falls and other serious adverse effects and (2) explore potential associations between the Risk Index for Overdose or Serious Opioid‐induced Respiratory Depression (CIP‐RIOSORD) risk class and other patient factors with falls and serious opioid adverse effects. This was an observational study of 44 participants discharged home from the emergency department with an opioid prescription for acute pain and followed for 30 days. We found pain interference may predict opioid‐related falls or serious adverse effects within older, opioid‐treated patients. If validated, pain interference may prove to be a beneficial marker for risk stratification of older adults initiated on opioids for acute pain.
15‐color highly sensitive flow cytometry assay for post anti‐CD19 targeted therapy (anti‐CD19‐CAR‐T and blinatumomab) measurable residual disease assessment in B‐lymphoblastic leukemia/lymphoma: Real‐world applicability and challenges
Authors: Chatterjee Gaurav , Dhende Priyanka , Raj Simpy , Shetty Vruksha , Ghogale Sitaram , Deshpande Nilesh , Girase Karishma , Patil Jagruti , Kalra Aastha , Narula Gaurav , Dalvi Kajal , Dhamne Chetan , Moulik Nirmalya Roy , Rajpal Sweta , Patkar Nikhil V. , Banavali Shripad , Gujral Sumeet , Subramanian Papagudi G. , Tembhare Prashant R. 
Published: September 2023

AbstractObjectivesMeasurable residual disease (MRD) is the most relevant predictor of disease‐free survival in B‐cell acute lymphoblastic leukemia (B‐ALL). We aimed to establish a highly sensitive flow cytometry (MFC)‐based B‐ALL‐MRD (BMRD) assay for patients receiving anti‐CD19 immunotherapy with an alternate gating approach and to document the prevalence and immunophenotype of recurrently occurring low‐level mimics and confounding populations.MethodsWe standardized a 15‐color highly‐sensitive BMRD assay with an alternate CD19‐free gating approach. The study included 137 MRD samples from 43 relapsed/refractory B‐ALL patients considered for anti‐CD19 immunotherapy.ResultsThe 15‐color BMRD assay with CD22/CD24/CD81/CD33‐based gating approach was routinely applicable in 137 BM samples and could achieve a sensitivity of 0.0005%. MRD was detected in 29.9% (41/137) samples with 31.7% (13/41) of them showing <.01% MRD. Recurrently occurring low‐level cells that showed immunophenotypic overlap with leukemic B‐blasts included: (a) CD19+CD10+CD34+CD22+CD24+CD81+CD123+CD304+ plasmacytoid dendritic cells, (b) CD73bright/CD304bright/CD81bright mesenchymal stromal/stem cells (CD10+) and endothelial cells (CD34+CD24+), (c) CD22dim/CD34+/CD38dim/CD81dim/CD19−/CD10−/CD24− early lymphoid progenitor/precursor type‐1 cells (ELP‐1) and (d) CD22+/CD34+/CD10heterogeneous/CD38moderate/CD81moderate/CD19−/CD24− stage‐0 B‐cell precursors or ELP‐2 cells.ConclusionsWe standardized a highly sensitive 15‐color BMRD assay with a non‐CD19‐based gating strategy for patients receiving anti‐CD19 immunotherapy. We also described the immunophenotypes of recurrently occurring low‐level populations that can be misinterpreted as MRD in real‐world practice.
Tumor microenvironment and CAR‐T cell immunotherapy in B‐cell lymphoma
Authors: Cai Fengqing , Zhang Junfeng , Gao Hui , Shen Hongqiang 
Published: September 2023

AbstractChimeric receptor antigen T cell (CAR‐T cell) therapy has demonstrated effectiveness and therapeutic potential in the immunotherapy of hematological malignancies, representing a promising breakthrough in cancer treatment. Despite the efficacy of CAR‐T cell therapy in B‐cell lymphoma, response variability, resistance, and side effects remain persistent challenges. The tumor microenvironment (TME) plays an intricate role in CAR‐T cell therapy of B‐cell lymphoma. The TME is a complex and dynamic environment that includes various cell types, cytokines, and extracellular matrix components, all of which can influence CAR‐T cell function and behavior. This review discusses the design principles of CAR‐T cells, TME in B‐cell lymphoma, and the mechanisms by which TME influences CAR‐T cell function. We discuss emerging strategies aimed at modulating the TME, targeting immunosuppressive cells, overcoming inhibitory signaling, and improving CAR‐T cell infiltration and persistence. Therefore, these processes enhance the efficacy of CAR‐T cell therapy and improve patient outcomes in B‐cell lymphoma. Further research will be needed to investigate the molecular and cellular events that occur post‐infusion, including changes in TME composition, immune cell interactions, cytokine signaling, and potential resistance mechanisms. Understanding these processes will contribute to the development of more effective CAR‐T cell therapies and strategies to mitigate treatment‐related toxicities.
Beyond acquiescence and compromise: Organizational strategies in pluralizing institutional environments
Authors: Dahlmans Han , Goessling Tobias , Kenis Patrick 
Published: September 2023

AbstractWe set out to investigate how organizations respond to the variety of requirements as experienced in their pluralizing institutional environments. We found that, in addition to acquiescence and compromise, Dutch vocational education and training (VET) organizations predominantly respond with cooperation and coordination strategies. Extensive multistage qualitative data analysis of 26 semi‐structured in‐depth interviews with management team (MT) members showed that cooperation and coordination are viable and effective response strategies to face a divergent and highly differentiated set of sometimes‐conflicting institutional requirements. Our study advances understanding of how organizations deploy strategic choice to arrive at their strategic responses. It offers organizational leaders, legislators, policymakers, and other constituents' insights into complex reality of how contemporary organizations actually relate to and act in their pluralizing institutional environments.
Molybdenum substituted M‐type hexagonal barium ferrite for high microwave absorption performance
Authors: Wu Junpeng , Dong Shijun , Li Huan , Zheng Hui , Wu Qiong , Zheng Peng , Zheng Liang 
Published: September 2023

AbstractWith the advancement of electrical and electronic devices, overcoming electromagnetic pollution turns into an urgent problem. In this work, high‐valence molybdenum (Mo6+) was doped into M‐type hexagonal barium ferrite (BaFe12‐xMoxO19) to improve its electromagnetic performance. The relationship between the Mo6+ doping concentration and the crystallographic structure, morphology and electromagnetic properties was studied in detail. Structural characterizations authenticate that the Mo6+ ions prefer the 2b site, increasing the lattice values and grain size, and boosting more Fe3+ conversion into Fe2+. The magnetic hysteresis loops demonstrate a reduction of saturation magnetization and coercivity values with the increase of Mo6+ concentration. While the microwave absorption properties were obviously improved by the doping Mo6+, and obtained the highest RLmin value of ‐56.12 dB@16.1 GHz and effective absorption bandwidth of 4.2 GHz at x = 0.1, displaying a potential role in absorbing material.
Should we extend the currency of cognitive ability test scores? Considerations from construct, equity, and psychometric perspectives in medical selection
Authors: Chiavaroli Neville , Le Luc , Parker‐Newlyn Lyndal , Pywell Sean 
Published: September 2023

AbstractScores on cognitive ability tests used in tertiary admissions contexts generally have very limited currency. This can have significant implications for prospective applicants to high‐demand courses which use cognitive tests as part of the selection process. In this paper we present both psychometric and non‐psychometric considerations regarding the score currency of ability tests, using GAMSAT (Graduate Medical School Admissions Test) as an example. We found that GAMSAT scores showed sufficient stability at the cohort level for institutions to be reasonably confident that a test score would continue to provide a valid representation of cognitive ability for up to a 5‐year period. However, candidates’ pre‐test preparation will influence whether it is in their interest to re‐sit a test even within an extended currency period.
Informing the development of a fit‐for‐purpose mental health nursing curriculum: A survey of mental health nurse academics in Australia
Authors: Lakeman Richard , Foster Kim , Happell Brenda , Hazelton Mike , Moxham Lorna , Hurley John 
Published: September 2023

AbstractInadequate mental health nursing content in pre‐registration nursing curricula has been the topic of debate and concern since the introduction of comprehensive nursing education in Australia. Government‐initiated inquiries and the efforts of mental health professional organizations and leaders have not successfully addressed this problem. The aim of the current study was to garner the perspectives and experiences of mental health nurse academics regarding the adequacy of mental health content in producing graduates able to work effectively in mental health settings and identify barriers and enablers to implementing and sustaining sufficient mental health content in pre‐registration programs. A survey was distributed to mental health academics in Australian universities offering pre‐registration nursing degrees. In total, 44 complete responses were included in the analysis. The results demonstrated the following: Most participants considered the current mental health content, theory and clinical hours insufficient to prepare graduates for practice in mental health settings. They reported a scarcity of tenured mental health nurse academics to deliver content effectively. Most participants were dissatisfied with the comprehensive approach to nurse education and preferred a double degree (nursing and mental health nursing), or a direct entry mental health nursing program. These findings provide further evidence for the current crisis in mental health nursing education and highlight the need for urgent action. People accessing health services have the right to receive high‐quality care from appropriately qualified nurses. The inadequacy of mental health content in these programs effectively denies vulnerable people the standard of care and treatment they should be entitled to.
Fracture‐related wound infections following surgical treatment of fractures in HIV‐positive and HIV‐negative patients: A meta‐analysis
Authors: Chen Huizhen , Zhu Yuxia , Chen Qiu 
Published: September 2023

AbstractThe meta‐analysis aims to evaluate and compare fracture‐associated wound infections (FAWIs) following surgical treatment of fractures in human immunodeficiency virus (HIV)‐positive and HIV‐negative patients. Examinations comparing HIV‐negative to HIV‐negative for fracture was among the meta‐analysis from various languages that met the inclusion criteria. Using dichotomous random or fixed models, the results of these investigations were examined, and the Odds ratio (OR) with 95% confidence intervals was computed (CIs). 14 examinations from 1991 to 2023 were recruited for the current analysis including 3528 personals with fractures. HIV‐positive had significantly higher FAWI before antiretroviral (OR, 3.59; 95% CI, 2.01–6.41, p < 0.001) compared to HIV‐negative personals with fractures. However, no significant difference was found between HIV‐positive and HIV‐negative in FAWI after antiretroviral (OR, 0.58; 95% CI, 0.30–1.12, p = 0.10) in personals with fractures. The examined data revealed that HIV‐positive had significantly higher FAWI before antiretroviral, however, no significant difference was found in FAWI after antiretroviral compared to HIV‐negative personals with fractures. Nevertheless, caution should be exercised while interacting with its values since some of the chosen examinations were found with a low sample size and a low number of examinations were found for the comparisons studied for the meta‐analysis.
Are U.S. Companies Too Short‐Term Oriented? Some Thoughts
Authors: Kaplan Steven N. 
Published: September 2023

Today's widespread criticism of U.S. companies as shortsighted and ever willing to sacrifice their future for near‐term profit is by no means new. As the author of this article shows, such charges of short‐termism have a long history that goes back at least 40 years. But as he goes on to point out, if these claims were warranted, then the effects we have been warned about all these years would surely have shown up by now.But it is difficult to find evidence of such effects. For example, a short‐term orientation has not been reflected in any erosion of corporate profitability over time. As the author reports, the ratio of U.S. corporate profits as a percentage of U.S. GDP has not only been on a generally upward trend since the early 1980s, but has never been higher than in the past few years. And corporate spending on R&D has also gone up sharply during this period, from 1.1% of GDP in 1977 to 1.7% in 2016. What's more, evidence of short‐termism has not shown up in either higher amounts of investment, or higher rates of return, by venture capitalists and private equity firms, which are both in a good position to profit from widespread corporate failure to pursue valuable growth opportunities.Nor do stock market investors appear to encourage corporate short‐termism, given their willingness to fund IPOs of companies with no previous earnings, and to assign high price‐earnings multiples to companies, like Amazon and Tesla, whose reported earnings have been modest at best. What's more, the fact that today's P/E and CAPE ratios are at relatively high levels suggests that the market continues to expect significant rates of growth by U.S. companies.Some critics, to be sure, have argued that the high level of corporate buybacks and other distributions of cash, when combined with today's near‐record corporate cash holdings, provide clear evidence of a widespread failure of companies to invest in their future. But as the author notes, such distributions in fact represent a fairly small fraction—only around 20%—of after‐tax corporate net income after infusions of new debt and equity capital are also taken into account.
Midwives Safeguarding Abortion Access: Establishing Medication Abortion Services
Authors: Weintraub Sharon A. , Versace Autumn , Winston Liza , Graff Brianna , Kattan David 
Published: September 2023

AbstractThe abortion access landscape for patients has changed dramatically in the wake of the US Supreme Court Dobbs v. Jackson Women's Health Organization decision in June of 2022. In response, the Division of Midwifery at Baystate Medical Center in Springfield, Massachusetts, began a medication abortion service for both established patients and those who may seek care from out of state. This service increases access to abortion care now while also providing the clinical experience needed for student nurse‐midwives to become future abortion providers. This article outlines the steps taken to implement a medication abortion service and ways it can be adopted by other midwifery practices. Strategies to address possible clinical, administrative, and logistical challenges are addressed. Finally, this article is a call to action because midwives are well qualified to provide high quality, safe, and comprehensive medication abortion within the midwifery model of care.
Novel COL6A3 frameshift variant in American Staffordshire Terrier dogs with Ullrich‐like congenital muscular dystrophy
Authors: Jankelunas Leanne , Murthy Vishal D. , Chen Annie V. , Minor Katie M. , Friedenberg Steven G. , Cullen Jonah N. , Guo Ling T. , Mickelson James R. , Shelton G. Diane 
Published: September 2023

AbstractTwo (male and female) 10‐month‐old American Staffordshire Terrier littermates presented for progressive weakness, joint contracture, and distal limb joint hyperlaxity beginning around 6 months of age. Neurological examination, serum creatine kinase activity, infectious disease titers, cerebrospinal fluid analysis, and electrodiagnostic testing were performed. Muscle biopsies were collected for histopathology and immunofluorescence staining for localization of dystrophy associated proteins. Whole‐genome sequencing (WGS) was performed on 1 affected dog. Variants were compared to a database of 671 unaffected dogs of multiple breeds. Histopathology confirmed a dystrophic phenotype and immunofluorescence staining of muscle cryosections revealed an absence of staining for collagen‐6. WGS identified a homozygous 1 bp deletion in the COL6A3 gene, unique to the first affected dog. Sanger sequencing confirmed the homozygous presence of the frameshift variant in both affected dogs. This report describes the clinical features and most likely genetic basis of an Ullrich‐like recessively inherited form of congenital muscular dystrophy in American Staffordshire Terriers.
Greater variation in boreal plant community composition and community‐level traits at local‐ than regional‐scale
Authors: Standen Katherine M. , Baltzer Jennifer L. 
Published: September 2023

AbstractQuestionsRapid climate change in northern latitudes is expected to influence plant functional traits of the whole community (community‐level traits) through species compositional changes and/or trait plasticity, limiting our ability to anticipate climate warming impacts on northern plant communities. We explored differences in plant community composition and community‐level traits within and among four boreal peatland sites and determined whether intra‐ or interspecific variation drives community‐level traits.LocationBoreal biome of western North America.MethodsWe collected plant community composition and functional trait data along dominant topoedaphic and/or hydrologic gradients at four peatland sites spanning the latitudinal extent of the boreal biome of western North America. We characterized variability in community composition and community‐level traits of understorey vascular and moss species both within (local‐scale) and among sites (regional‐scale).ResultsAgainst expectations, community‐level traits of vascular plant and moss species were generally consistent among sites. Furthermore, interspecific variation was more important in explaining community‐level trait variation than intraspecific variation. Within‐site variation in both community‐level traits and community composition was greater than among‐site variation, suggesting that local environmental gradients (canopy density, organic layer thickness, etc.) may be more influential in determining plant community processes than regional‐scale gradients.ConclusionsGiven the importance of interspecific variation to within‐site shifts in community‐level traits and greater variation of community composition within than among sites, we conclude that climate‐induced shifts in understorey community composition may not have a strong influence on community‐level traits in boreal peatlands unless local‐scale environmental gradients are substantially altered.
Low‐coverage whole genome sequencing for highly accurate population assignment: Mapping migratory connectivity in the American Redstart (Setophaga ruticilla)
Authors: DeSaix Matthew G. , Anderson Eric C. , Bossu Christen M. , Rayne Christine E. , Schweizer Teia M. , Bayly Nicholas J. , Narang Darshan S. , Hagelin Julie C. , Gibbs H. Lisle , Saracco James F. , Sherry Thomas W. , Webster Michael S. , Smith Thomas B. , Marra Peter P. , Ruegg Kristen C. 
Published: September 2023

AbstractUnderstanding the geographic linkages among populations across the annual cycle is an essential component for understanding the ecology and evolution of migratory species and for facilitating their effective conservation. While genetic markers have been widely applied to describe migratory connections, the rapid development of new sequencing methods, such as low‐coverage whole genome sequencing (lcWGS), provides new opportunities for improved estimates of migratory connectivity. Here, we use lcWGS to identify fine‐scale population structure in a widespread songbird, the American Redstart (Setophaga ruticilla), and accurately assign individuals to genetically distinct breeding populations. Assignment of individuals from the nonbreeding range reveals population‐specific patterns of varying migratory connectivity. By combining migratory connectivity results with demographic analysis of population abundance and trends, we consider full annual cycle conservation strategies for preserving numbers of individuals and genetic diversity. Notably, we highlight the importance of the Northern Temperate‐Greater Antilles migratory population as containing the largest proportion of individuals in the species. Finally, we highlight valuable considerations for other population assignment studies aimed at using lcWGS. Our results have broad implications for improving our understanding of the ecology and evolution of migratory species through conservation genomics approaches.
Hybrid random aggregation model and Bayesian optimization‐based convolutional neural network for estimating the concrete compressive strength
Authors: Li Kai , Pan Lei , Guo Xiaohui , Wang Yuan Feng 
Published: September 2023

AbstractNumerous experimental studies have shown the type and gradation of coarse aggregates effect on the mechanical properties of concrete. The type and gradation of coarse aggregates have not been taken into account in the available machine learning prediction models. In this study, a two‐dimensional concrete microscopic image was generated by using a random aggregate model (RAM), and the coarse aggregate and other concrete ingredients were represented innovatively using polygons and trichromatic chromaticity values in the RAM images. The RAM image set was created by applying this method to represent 1110 sets of different concrete mixes. Then based on the Bayesian optimization algorithm and the image set, a compressive strength prediction model considering the effect of coarse aggregate types and gradations was developed utilizing a convolutional neural network (CNN) model. Meanwhile, an artificial neural network (ANN) compressive strength prediction model was developed using 1110 sets of mix ratio data. The results show that the proposed RAM image generation method has the capability to represent different concrete mix ratios collected in this study. The prediction performance of the CNN compressive strength model considering aggregate types and gradations is better than that of the ANN model. The method can provide a new perspective for predicting other concrete mechanical properties and technically support performance‐based intelligent concrete mix design.
Pulsed‐field ablation of pulmonary vein and left atrial posterior wall combined with left atrial appendage occlusion as single procedure
Authors: Bianchini Lorenzo , Moltrasio Massimo , Fassini Gaetano , Cellucci Selene , Sicuso Rita , Ribatti Valentina , Dessanai Maria Antonietta , Pizzamiglio Francesca , Vettor Giulia , Majocchi Benedetta , Tundo Fabrizio , Riva Stefania , Carbucicchio Corrado , Tondo Claudio 
Published: September 2023

AbstractPulmonary vein isolation and left atrial posterior wall ablation using the Farapulse system, followed by left atrial appendage occlusion, have been achieved as single combined procedure to treat long‐standing persistent atrial fibrillation in a patient at high hemorrhagic risk.