bluuebunny/crossref_metadata_2025_split huggingface dataset:
Luteolin-Zinc Modulates PRR11 Methylation and Ferroptosis in Lung Cancer Cells Under Hypoxia
Authors: Huang Jiayong , Fang Binbo , Guo Ting , Li Yiyang , Yang Yilin , Ying Jiongcheng , Zhou Haoyun , Li Xiang 
Published: January 2025

Background Activation of PRR11 contributes to the progression of lung cancer and is related to its methylation status. However, the regulatory mechanism of luteolin-zinc (Lu-Zn) on PRR11 methylation-mediated lung cancer progression under hypoxic conditions remains to be explored.. Purpose This study aims to investigate the inhibitory effect of Lu-Zn on lung cancer cells, its regulation of ferroptosis, and the role of PRR11 in lung cancer progression under hypoxia. Methods In vitro experiments were conducted to evaluate the effect of Lu-Zn on lung cancer cells, focusing on its impact on invasion, migration, and ferroptosis. The expression levels of PRR11, its methylation status, and microRNA-6769b-3p (miR-6769b-3p) were also analyzed. Results Under hypoxic conditions, Lu-Zn significantly inhibited the invasion and migration abilities of lung cancer cells and promoted ferroptosis. Additionally, Lu-Zn reversed the pro-cancer effects induced by PRR11. At the molecular level, Lu-Zn promoted the methylation of PRR11 and regulated miR-6769b-3p. Conclusion Our study demonstrates that Lu-Zn enhances the methylation of PRR11 and reduces its expression under hypoxic conditions through miR-6769b-3p. This leads to inhibition of the downstream PI3K/AKT/mTOR signaling pathway, promoting ferroptosis and exerting anti-lung cancer effects.
Patient factors associated with treatment completion in a 12-week inpatient dual diagnosis treatment program
Authors: Membrey Dean , Naren Thileepan , Cook Jon , MacCartney Paul , Brown Dianne 
Published: January 2025

Objective To identify whether mental health wellbeing, age, gender or recent substance use pattern affected completion rates of a dual diagnosis inpatient program. Method This retrospective cohort study reviewed medical records of patients admitted between October 2018 and December 2021 of Westside Lodge, a dual diagnosis inpatient program. Demographic information, mental health screening tool results (BASIS-24) and self-reported substance use data were accessed from the patients’ electronic medical records. Results 181 admissions were included in the study, of which the majority were male (53.6%). Recently used common substances were alcohol (52%), cannabis (40%) and methamphetamine (43%). None of the factors studied demonstrated any statistically significant effect on the likelihood of program completion. Conclusion This study found that age, gender, mental health wellbeing and recent substances used were not associated with the likelihood of completing inpatient dual diagnosis treatment though further high-powered studies are required to validate these claims.
Comparing Competitive Integrated Employment Outcomes in The State-federal Vocational Rehabilitation Program Among Individuals with Cognitive, Physical, and Sensory Functional Impairments
Authors: Ahonle Zaccheus J , Wei Tianlan , Rumrill Phillip D , Dillahunt-Aspillaga Christina 
Published: January 2025

Background State-Federal vocational rehabilitation (VR) services are available for eligible individuals with disabilities (IWD) who are interested in pursuing, obtaining, and maintaining gainful employment. Despite availability of VR services, employment outcomes of IWD compared to those without disabilities continue to be limited. Objective To examine effects of receipt of VR services on the employment outcomes of individuals with cognitive impairments (CI) compared to people with other impairments (i.e., physical and sensory impairments) while accounting for individual characteristics and patterns of VR service use. Methods Secondary data analysis using Rehabilitation Services Administration (RSA) 911 data covering cases in 2019. Hypothesized covariates and predictors of employment outcomes were divided into four groups: demographic variables, environmental/social variables, disability related variables, and receipt of VR services. The target outcome variables from the RSA 911 database were competitive integrated employment (CIE) employment outcome, hourly wage at case closure, and hours worked in a week at case closure. A hierarchical logistic regression analysis was performed using CIE as the criterion. Results Findings suggest that (a) the group including CI individuals was at a disadvantage in terms of CIE outcomes; (b) from the logistic regression, gender, education level, significance of disability, and receipt of some VR services were significantly associated with CIE outcomes (yes/no); and (c) when we examined the percentages of individuals receiving VR services, higher percentages of individuals with CI received varieties of VR services, but less assistive technology services. Conclusions Individuals with disabilities continue to experience disparate employment outcomes. The receipt of varieties of VR services facilitates IWDs to successfully obtain CIE. Receipt of VR services alone may not be the only factor that supports IWD in obtaining successful CIE. A critical investigation of the quality and type of these VR services, difference by impairment, and the economic impact of societal/environmental trends is warranted.
How Game Features and Treatment-Related Factors Facilitate Generalization in Technology-Based Aphasia Rehabilitation: A Systematic Review
Authors: Gorshkov Georgii , Buivolova Olga , Gavrilova Elena , Dragoy Olga 
Published: January 2025

Background Nowadays, developers offer mobile applications for aphasia treatment. Although their overall effectiveness and acceptance by the target audience was proved, it has not been established what aspects of technology-based aphasia rehabilitation facilitate these improvements and translate into generalization. Objective The objectives were to analyze what technology- and treatment-related factors, including treatment dose, intensity and duration, affect treatment efficacy and facilitate generalization. Methods The PubMed and ScienceDirect databases were searched in February 2024. The review included experimental articles testing mobile- or computer-based applications for aphasia rehabilitation. Studies were excluded if they described AAC techniques or assistive tools, or focused solely on quality of life. ROB-2 was used to assess risk of bias in the included randomized controlled trials. Results Eighteen articles meeting the inclusion criteria were analyzed. The key factors increasing the therapy effect and leading to generalization were automatic feedback, diversity of the tasks employed in the training, longer periods of treatment, and interaction between the user and the clinician. Conclusions Technology-based aphasia treatment is an effective therapy tool. Contact with the clinician, simultaneous practice targeted at various language domains and executive functions, as well as feedback, positively influence outcomes. The review, however, has limitations, as it lacks statistical analysis and synthesizes heterogeneous data.
How Much Pain Medication Do Patients Require After Posterior Iliac Crest Bone Graft to the Alveolar Cleft?
Authors: Deek Andrew J. , Jindal Snigdha , Bridges Kate , Varidel Alistair , Padwa Bonnie L. , Resnick Cory M. 
Published: January 2025

Objective The purpose of this study was to quantify analgesic use following alveolar cleft bone grafting (ABG) utilizing a posterior iliac crest (PIC) donor site. Design This is a prospective cohort study of consecutive patients that underwent ABG with PIC in a 10 month period from November 2022 to September 2023. Setting Tertiary care free-standing pediatric hospital. Participants Patients with cleft lip and alveolus with or without cleft of the secondary palate undergoing alveolar bone graft with cancellous marrow from the PIC. Interventions All patients underwent ABG and recorded analgesic use afterwards. Main Outcome Measure The main outcome variable was total pain medication utilization during the first 10 postoperative days (PODs). Results 22 subjects (72.7% male, 54.5% Caucasian 72.7% unilateral and 27.3% bilateral clefts) recorded pain medication use. Total duration of analgesic use (any type) was 3.86 ± 1.7 postoperative days. 10 subjects (45.5%) did not use opioid medication postoperatively. The remaining 12 subjects (54.5%) used a median of 12 (0, 19) morphine milli-equivalents (MME), equal to 1.6 (0, 2.53) doses of 5 mg oxycodone. An average of 9.9 ± 5.6 doses of acetaminophen and 9.1 ± 4.7 doses of a non-steroidal anti-inflammatory drug (NSAID) were administered. No subject used opioids after POD3. Patients with unilateral clefts used more acetaminophen ( p = 0.02); otherwise, there were no significant differences in outcomes based on any predictor variable ( p > 0.05). Conclusions Analgesic requirements after ABG with PIC were minimal, with nearly half of patients taking no postoperative opioids. As such, judicious opioid prescribing is prudent.
Evaluation of the Toxicity and Outcomes of the Combination of Midostaurin and CLAG-M in Patients With FLT3-Mutated Acute Myeloid Leukemia (AML): A Multicenter Retrospective Analysis
Authors: Chen Ashley , Baek Grace , Russell Kathryn , Shaw Carole , Othus Megan , Cohen Jonathan , Palmer Shannon , Rasmussen Jack , Bubalo Joseph , Tsomo Tenzin , Schwarz Tenley , Namburi Swathi , Halpern Anna 
Published: January 2025

Background: Addition of midostaurin to standard “7+3” (cytarabine and anthracycline) significantly prolongs overall and event-free survival. At University of Washington/Fred Hutchinson Cancer Center (UW/FHCC), the standard regimen for newly diagnosed (ND) and relapsed/refractory (R/R) AML is cladribine, high-dose cytarabine, GCSF, and mitoxantrone (CLAG-M); midostaurin is added if FLT3-mutated. There is limited data on the use of FLT3-inhibitors with high-dose cytarabine regimens in AML. Objective: This study aimed to evaluate the safety and efficacy of the combination of midostaurin with CLAG-M versus midostaurin plus 7+3 in FLT3-mutated AML patients. Methods: This is a retrospective, multicenter review including FLT3-mutated AML patients undergoing (re)induction chemotherapy with either CLAG-M or 7+3 at UW/FHCC, Oregon Health & Science University, and Swedish Cancer Institute. The primary outcome was incidence of adverse events. Secondary outcomes included disease response per ELN2017 criteria and 28-day mortality. Excluded were patients on clinical trials or who started midostaurin 30 days after chemotherapy. Results: Eighty patients treated from September 2016 to December 2023 were included; 36 patients received CLAG-M, and 44 patients 7+3. Baseline characteristics were similar across all institutions. Adverse event rates were similar between the 2 cohorts, except diarrhea and bleeding which were more common in the 7+3 cohort. The rate of complete remission (CR) plus CR with incomplete blood count recovery did not significantly differ between the 2 cohorts: CLAG-M, 86% versus 7+3, 70% ( P = 0.11). Conclusion & relevance: The toxicity profile of CLAG-M combined with midostaurin is comparable with the combination of 7+3 with midostaurin, and induces high remissions rates in adults with FLT3-mutated AML.
An Evaluation of Iloperidone for Mania in Bipolar I Disorder
Authors: Caskey Kelen , Nelson Leigh Anne 
Published: January 2025

Objective: To review the efficacy of iloperidone for mania associated with bipolar I disorder and discuss its safety profile (eg, QTc prolongation, orthostatic hypotension, and metabolic adverse effects). Data sources: Literature was identified using PubMed (1966-September 2024), OVID (1984-November 2024), and clinicaltrials.gov. Search terms included iloperidone, bipolar disorder, and mania. Study selection and data extraction: The study included trials evaluating iloperidone for treating bipolar mania. Data synthesis: In one phase 3 study, iloperidone demonstrated significant improvement in mania symptoms at day 28 on all primary (ie, Young Mania Rating Scale) and secondary outcomes (Clinical Global Impression-Severity/Change scales) compared to placebo. Iloperidone was well tolerated, with tachycardia, dizziness, dry mouth, alanine aminotransferase elevation, nasal congestion, increased weight, and somnolence reported as common adverse effects. Relevance to patient care and clinical practice in comparison to existing drugs: Since there are no head-to-head studies comparing iloperidone with other second-generation antipsychotics for bipolar mania, other treatment considerations drive medication selection. Iloperidone is unavailable in a generic formulation; thus, its use will be associated with higher costs. It is dosed twice daily, which may negatively impact adherence. Iloperidone is associated with a moderate risk of QTc prolongation, metabolic adverse effects, and orthostatic hypotension, which will limit its use in certain patient populations. QTc prolongation is dose related, so drug interactions involving CYP2D6 and CYP3A4 inhibition can have serious consequences. Conclusion: In the pivotal trial, iloperidone was effective in treating adults with an acute manic or mixed episode associated with bipolar I disorder and was safe and well tolerated.
Effects of home-based interventions on cognitive performance in patients with dementia: A systematic review and meta-analysis
Authors: Ma Xichao , Wang Yu , Chen Xinxin , Zhu Shijie , Lin Yang , Liu Shaxin , Yang Yonghong 
Published: January 2025

Background With increasing age, dementia is a common disease in the elderly population，especially Alzheimer's disease. Owing to the nature of the disease, the function of patients deteriorates, which places a heavy burden on the country and family. Home-based training programs have been shown to improve cognitive function in patients with dementia. Objective To examine the effects and methods of home-based interventions on the cognitive performance of patients with dementia. Methods This systematic review and meta-analysis was conducted on the basis of the PRISMA statement. This protocol was registered in advance at PROSPERO (CRD42021277269). Six English electronic databases, including PubMed, EMBASE, the Cochrane Library, Web of Science, SCOPUS, and OTseeker, were searched and updated to January 31, 2024. Two researchers independently completed the literature retrieval and data extraction. RevMan 5.3 software was used to analyze the data. The standardized mean difference and the 95% confidence interval were used for statistical analysis. Subgroup analyses were performed by assessment tools, intervention duration and intervention methods. Results Twenty randomized controlled trials with 3543 participants were included in the qualitative synthesis, and 17 studies were included in the meta-analysis. Compared with the control intervention, the home-based intervention significantly improved cognitive performance (SMD = 0.45; 95% CI = [0.17, 0.74]; p = 0.002). Conclusions Moderate to high evidence shows that home-based interventions significantly improve the cognitive performance of patients with dementia, especially their comprehensive cognitive function.
Cross-sectional and prognostic associations of baseline [18F]GTP1 tau PET signal and white matter lesion volumes for cognitive and functional decline in prodromal-to-mild Alzheimer's disease
Authors: Ruiz-Uribe Nancy E , Manser Paul , Butcher Brandon , Li Yihao , Blendstrup Mira , Baker Suzanne , Sanabria Bohorquez Sandra , Teng Edmond 
Published: January 2025

Background In Alzheimer's disease (AD), tau and white matter lesion pathology are associated with clinical severity and subsequent decline, but their relative relationships with clinical assessments remain uncertain. Objective To examine cross-sectional and prognostic associations between baseline [18F]GTP1 tau positron emission tomography (PET) standardized uptake value ratio (SUVRs) and T1 white matter hypointensity (WMHypo) volumes with clinical indices. Methods We analyzed participants with biomarker-confirmed prodromal (n = 127) or mild (n = 233) AD with baseline [18F]GTP1 tau PET and MRI and longitudinal Clinical Dementia Rating-Sum of Boxes (CDR-SB), 13-item version of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog13), Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Mini-Mental Status Examination (MMSE), and Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) data. Results Higher baseline [18F]GTP1 SUVRs were independently associated with poorer baseline performance and faster rates of subsequent decline on all five clinical outcome measures. Higher baseline WMHypo volumes were independently associated with poorer baseline performance on the CDR-SB, ADAS-Cog13, RBANS, and MMSE and faster rates of subsequent decline on the CDR-SB and ADCS-ADL. Conclusions The independent associations of tau and white matter lesion pathology with clinical decline in AD suggest future prognostic models should include both imaging modalities.
Effect of genetic and vascular risk factors on rates of cognitive decline in early-onset and late-onset Alzheimer's disease
Authors: Li Yunyi , Sanjay Apoorva Bharthur , Manchella Mohit , Mishra Aryan , Logan Paige E , Kim Hee Jin , Risacher Shannon L , Gao Sujuan , Apostolova Liana G ,   for the Alzheimer's Disease Neuroimaging Initiative *
Published: January 2025

Background Although previous studies have shown that cognitive decline in Alzheimer's disease (AD) is associated with various risk factors, they primarily focused on late-onset AD (LOAD). Objective We aim to evaluate the differential impact of risk factors on the cognitive decline between early-onset AD (EOAD, onset < 65 years) and LOAD (onset [Formula: see text] 65 years) and explore the longitudinal effect of Apolipoprotein E allele 4 ( APOE ε4) on cortical atrophy in both cohorts. Methods Using data from 212 EOAD and 1101 LOAD participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI), we conducted multivariable mixed-effect models to evaluate the impact of APOE ε4, education, hypertension, diabetes, dyslipidemia, and body mass index on cognitive performance. Preprocessed MRI data were utilized for longitudinal parametric mapping. Results APOE ε4 carriers in both groups showed significantly accelerated declines in language, verbal memory, executive function, and general cognition. By controlling other significant risk factors, APOE ε4 carriers showed faster declines in language and verbal memory in both groups. Females exhibited accelerated declines in Language and verbal memory in the EOAD and LOAD cohorts respectively. LOAD individuals with hypertension showed faster declines while overweight and obese participants displayed slower declines in both cohorts across all domains except visuospatial. Notably, APOE ε4 status was associated with longitudinal cortical atrophy in the LOAD cohort but not in the EOAD cohort. Conclusions Known risk factors for AD were associated with cognitive decline in both EOAD and LOAD cohorts.
The Relationship Between College Students’ Perceptions of Their Physical Activity Class Climate to Their Feelings of Thriving and Mental Well-being
Authors: Strande Kaytlin Marlee , Fry Mary D. , Long Haiying 
Published: January 2025

Objective The purpose of this study was to examine the relationship between students’ perceptions of a caring and task-involving climate (C/TIC) in their college physical activity courses (PACs) to their feelings of thriving and mental well-being across a semester. Design College students enrolled in PACs for college credit volunteered to complete a survey that included measures of their PAC climate, thriving, and mental well-being. Setting College students enrolled in a PAC at a large Midwestern university. Method Students completed the survey twice, at approximately 4 weeks (time 1) and 12 weeks (time 2) into the semester. Results No significant changes were observed in the variables (class climate, thriving, and mental well-being) from time 1 to time 2. However, perceptions of a C/TIC at time one predicted thriving and mental well-being scores at time two. Conclusion Researchers may explore how universities can provide training to instructors to foster a C/TIC to heighten students’ thriving and mental well-being.
How does mHealth benefit older Chinese adults’ quality of life? Examining the roles of eHealth literacy, health motivation, and patient activation
Authors: Qiu Sha Sarah , Ye Jizhou Francis , You Fei , Liu Muhan , Zhao Xinshu 
Published: January 2025

Background China is experiencing a rapid increase in its aging population, leading to the emergence of significant challenges to improve the quality of life (QoL) of older adults. The study aims to explore the potential benefits of using mobile health technology in improving the QoL for older Chinese adults. Method This study utilized a subsample of adults aged 60 and above from a cross-sectional, population-based national survey conducted among Chinese adults (N = 852). A moderated mediation analysis was conducted to investigate the impact of mHealth use on older Chinese adults’ QoL, focusing on the mediating roles of eHealth literacy and patient activation and the moderating effect of motivation for health promotion and prevention. Result The results indicate that mHealth use directly enhances the QoL of older Chinese adults (β = .061, p < .001), and this effect is mediated by eHealth literacy and patient activation (β = .057, Boots 95% CI [.044, .072]). Furthermore, motivation for health promotion and prevention moderates the relationship between eHealth literacy and patient activation (β = .133, p < .001). Conclusion These results demonstrate the positive impact of mHealth use on the QoL of older Chinese adults and reveal the underlying mechanisms involving mental and physical factors. These findings underscore the significance of increased attention to promoting mHealth use among older Chinese adults and provide a new way to enhance eHealth literacy and patient activation by encouraging the adoption of mHealth products.
Latest Developments in Targeted Biological Therapies in the Management of Chordoma and Chondrosarcoma
Authors: Biczo Adam , Sahgal Arjun , Verlaan Jorrit-Jan , Shreyaskumar Patel , Szoverfi Zsolt , Schultheiss Markus , Rhines Laurence , Reynolds Jeremy , Laufer Ilya , Gasbarrini Alessandro , Dea Nicolas , Gokaslan Ziya , Fisher Charles , Bettegowda Chetan , Boriani Stefano , Hornicek Francis , Goodwin Rory , Lazary Aron 
Published: January 2025

Study Design Systematic review. Objectives The objective of this review paper was to summarize targeted molecular therapy options for spinal chordoma and chondrosarcoma, and to provide an update on the relevant clinical trials open for recruitment. Methods A systematic review of the current literature was performed, according to PRISMA guidelines, to summarize the latest developments in non-surgical molecular treatment options for low grade malignant primary spinal tumours. We also summarize those actively recruiting clinical trials based on clinicaltrials.gov. Results A total of 73 studies and completed clinical trials were reviewed. Twenty actively recruiting clinical trials (eight for chordoma and twelve for chondrosarcoma) were identified. Conclusions There is a strong need to find new therapeutic options to complement surgical resection and radiation therapy, which remain the cornerstone of management. Targeted therapies against molecular pathways show promise as compared to conventional chemotherapy.