bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimorbidity status and annual healthcare expenditures of rheumatoid arthritis patients: a Dutch hospital-centered versus population-based comparison
Authors: Koster Fiona , Bakx Pieter L. H. , Kok Marc R. , Barreto Deirisa Lopes , Weel-Koenders Angelique E. A. M. 
Published: February 2023

AbstractThe prevalence of multimorbidity among rheumatoid arthritis (RA) patients is increasing and associated with worse outcomes. Therefore, management of multimorbid patients requires a multidisciplinary approach. However, healthcare systems consist of mono-disciplinary subsystems, which limits collaboration across subsystems. To study the importance of a multidisciplinary, integrated approach, associations between expenditures and multimorbidity are assessed in real-life data. Retrospective data on RA patients from a Dutch single-hospital are analyzed and compared to the Dutch RA population data. The Elixhauser index is used to measure the multimorbidity prevalence. Regression analyses were conducted to derive the relationship between multimorbidity, healthcare costs and self-reported quality of life (e.g. EQ-5D). When analyzing the impact of multimorbidity within RA patients in context of a single-hospital context, multimorbidity is only partially captured: 13% prevalence versus 24% of the Dutch population. Multimorbidity is associated with higher care expenditures. Depending on the type of multimorbidity, expenditures are €43–€5821 higher in a single-hospital and from €2259–€9648 in population data. Finally, medication use associated with chronic diseases and self-reported aspects of well-being are associated with similar increases in healthcare expenditures as multimorbidity based on hospital care. Within RA, a single-hospital approach underestimates the association between multimorbidity and healthcare expenditures as 43% of healthcare utilization and expenditures are missed. To overcome a single-provider perspective in healthcare and efficiently coordinate multimorbid patients, besides providing holistic care, professionals also need to use data providing comprehensive pictures of patients.
Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts
Authors: McKee Ann C. , Stein Thor D. , Huber Bertrand R. , Crary John F. , Bieniek Kevin , Dickson Dennis , Alvarez Victor E. , Cherry Jonathan D. , Farrell Kurt , Butler Morgane , Uretsky Madeline , Abdolmohammadi Bobak , Alosco Michael L. , Tripodis Yorghos , Mez Jesse , Daneshvar Daniel H. 
Published: February 2023

AbstractOver the last 17 years, there has been a remarkable increase in scientific research concerning chronic traumatic encephalopathy (CTE). Since the publication of NINDS–NIBIB criteria for the neuropathological diagnosis of CTE in 2016, and diagnostic refinements in 2021, hundreds of contact sport athletes and others have been diagnosed at postmortem examination with CTE. CTE has been reported in amateur and professional athletes, including a bull rider, boxers, wrestlers, and American, Canadian, and Australian rules football, rugby union, rugby league, soccer, and ice hockey players. The pathology of CTE is unique, characterized by a pathognomonic lesion consisting of a perivascular accumulation of neuronal phosphorylated tau (p-tau) variably alongside astrocytic aggregates at the depths of the cortical sulci, and a distinctive molecular structural configuration of p-tau fibrils that is unlike the changes observed with aging, Alzheimer’s disease, or any other tauopathy. Computational 3-D and finite element models predict the perivascular and sulcal location of p-tau pathology as these brain regions undergo the greatest mechanical deformation during head impact injury. Presently, CTE can be definitively diagnosed only by postmortem neuropathological examination; the corresponding clinical condition is known as traumatic encephalopathy syndrome (TES). Over 97% of CTE cases published have been reported in individuals with known exposure to repetitive head impacts (RHI), including concussions and nonconcussive impacts, most often experienced through participation in contact sports. While some suggest there is uncertainty whether a causal relationship exists between RHI and CTE, the preponderance of the evidence suggests a high likelihood of a causal relationship, a conclusion that is strengthened by the absence of any evidence for plausible alternative hypotheses. There is a robust dose–response relationship between CTE and years of American football play, a relationship that remains consistent even when rigorously accounting for selection bias. Furthermore, a recent study suggests that selection bias underestimates the observed risk. Here, we present the advances in the neuropathological diagnosis of CTE culminating with the development of the NINDS–NIBIB criteria, the multiple international studies that have used these criteria to report CTE in hundreds of contact sports players and others, and the evidence for a robust dose–response relationship between RHI and CTE.
Dysregulation of astrocytic Ca2+ signaling and gliotransmitter release in mouse models of α-synucleinopathies
Authors: Nanclares Carmen , Poynter Jonah , Martell-Martinez Hector A. , Vermilyea Scott , Araque Alfonso , Kofuji Paulo , Lee Michael K. , Covelo Ana 
Published: February 2023

Abstractα-Synuclein is a major component of Lewy bodies (LB) and Lewy neurites (LN) appearing in the postmortem brain of Parkinson's disease (PD) and other α-synucleinopathies. While most studies of α-synucleinopathies have focused on neuronal and synaptic alterations as well as dysfunctions of the astrocytic homeostatic roles, whether the bidirectional astrocyte–neuronal communication is affected in these diseases remains unknown. We have investigated whether the astrocyte Ca2+ excitability and the glutamatergic gliotransmission underlying astrocyte–neuronal signaling are altered in several transgenic mouse models related to α-synucleinopathies, i.e., mice expressing high and low levels of the human A53T mutant α-synuclein (G2-3 and H5 mice, respectively) globally or selectively in neurons (iSyn mice), mice expressing human wildtype α-synuclein (I2-2 mice), and mice expressing A30P mutant α-synuclein (O2 mice). Combining astrocytic Ca2+ imaging and neuronal electrophysiological recordings in hippocampal slices of these mice, we have found that compared to non-transgenic mice, astrocytes in G2-3 mice at different ages (1–6 months) displayed a Ca2+ hyperexcitability that was independent of neurotransmitter receptor activation, suggesting that the expression of α-synuclein mutant A53T altered the intrinsic properties of astrocytes. Similar dysregulation of the astrocyte Ca2+ signal was present in H5 mice, but not in I2-2 and O2 mice, indicating α-synuclein mutant-specific effects. Moreover, astrocyte Ca2+ hyperexcitability was absent in mice expressing the α-synuclein mutant A53T selectively in neurons, indicating that the effects on astrocytes were cell-autonomous. Consistent with these effects, glutamatergic gliotransmission was enhanced in G2-3 and H5 mice, but was unaffected in I2-2, O2 and iSyn mice. These results indicate a cell-autonomous effect of pathogenic A53T expression in astrocytes that may contribute to the altered neuronal and synaptic function observed in α-synucleinopathies.
The risk of central nodal metastasis based on prognostic factors of the differentiated thyroid carcinoma: a systematic review and meta-analysis study
Authors: Hafez Lamiaa Gomaa , Elkomos Beshoy Effat , El-Shafaei Mahmoud Ahmed Mohamed , Omran Hesham Mohamed Ali , Saad Ahmed Saeed 
Published: February 2023

Abstract
Background and aim
Despite improving the 10-year disease-free-survival, prophylactic central neck dissection (pCND) in differentiated thyroid carcinoma (DTC) should only be considered in patients with high risk factors for lymph node (LN) metastasis due to the increases in the risk of postoperative complications. Our aim was to identify the risk factors for central lymph node metastasis (CLNM) in DTC.

Method
We searched PubMed, Scopus, Web of science, Cochrane library for eligible studies from inception to November 1, 2021 and a systematic review and meta-analysis were carried out to identify the risk factors for CLNM in DTC.

Results
We included 41 studies with total of 27,741 patients in this study. The pooled results in this meta-analysis showed that these risk factors were significantly associated with CLNM: age < 45 years (odds ratio (OR) 1.64, 95% confidence interval (CI) 1.34–1.99, p < 0.00001), male sex (OR 1.73, 95% CI 1.54–1.93, p < 0.00001), multifocality (OR 1.87, 95% CI 1.59–2.19, p < 0.00001), bilateral disease (OR 1.43, 95% CI 1.15–1.78, p < 0.001), capsular invasion (OR 1.67, 95% CI 1.10–2.54, p < 0.02), lymphovascular invasion (OR 4.89, 95% CI 2.76–8.66, p < 0.00001) and extra-thyroidal extension (OR 2.43, 95% CI 1.97–3.00, p < 0.00001). In addition, young age (< 45 years), male sex, multifocality, and extra-thyroidal extension were significantly associated with large-volume CLNM in clinically N0 DTC patients. However, the presence of Hashimoto’s thyroiditis was not a predictors of large-volume CLNM.

Conclusion
Young age (< 45 years), male sex, bilateral disease, multifocality, capsular invasion, lymphovascular invasion and extra-thyroidal extension are significantly associated with CLNM and pCND would be expected to have a higher yield in patients with these risk factors.
Neuromuscular fatigue and muscle damage following a simulated singles badminton match
Authors: Lin Zengyuan , Blazevich Anthony J. , Abbiss Chris R. , Wilkie Jodie Cochrane , Nosaka Kazunori 
Published: February 2023

Abstract
Purpose
To understand muscle damage in badminton, changes in neuromuscular function were investigated after simulated badminton singles matches performed by ten state-level male players.

Methods
Each participant played eight matches and measurements were taken before, immediately after, and 1 and 24 h after each match. Maximal voluntary isometric contraction (MVC) torque of the knee extensors and flexors, voluntary activation (VA) during MVC and torques generated by doublet (TDoublet), 20 (T20) and 80 Hz (T80) electrical stimulations of the knee extensors were measured from the dominant leg (the racket-hold arm side). Muscle soreness was assessed by a 100-mm visual analogue scale from both legs. The number of lunges performed by each participant in each match was analysed by videos, and its relations to other measures were examined.

Results
Pre-match knee extensor and flexor MVC torques were 278.4 ± 50.8 Nm and 143.0 ± 36.2 Nm, respectively. Knee extensor MVC torque of the dominant leg decreased immediately (12.0 ± 2.9%) and 1 h post-match (16.0 ± 3.2%), but returned to baseline at 24 h post-match. VA (11.4 ± 2.9%), TDoublet (13.1 ± 6.0%), T20 (31.1 ± 12.3%) and T80 (25.5 ± 7.9%) decreased (p < 0.01) immediately post-match but recovered by 24 h post-match. A significant correlation (r = − 0.64, p < 0.01) was observed between the total number of lunges performed in a match (160–240 times) and the magnitude of decrease in MVC torque (6.4–14.7%). Muscle soreness developed more (p < 0.05) for the dominant (51.5 ± 11.6 mm) than the non-dominant leg (18.8 ± 8.6 mm).

Conclusion
Muscle damage induced by singles badminton matches was minimal, but the more the lunges are performed, the greater the neuromuscular fatigue.
Common inherited variants of PDCD1, CD274 and HAVCR2 genes differentially modulate the risk and prognosis of adenocarcinoma and squamous cell carcinoma
Authors: Moksud Nafeesa , Wagner Marta , Pawełczyk Konrad , Porębska Irena , Muszczyńska-Bernhard Beata , Kowal Aneta , Wiśniewski Andrzej , Kosacka Monika , Kończak Julia , Karpiński Paweł , Frydryk Dominik , Andrzejczak Anna , Karabon Lidia , Kuśnierczyk Piotr , Jasek Monika 
Published: February 2023

Abstract
Background
To investigate the association between single nucleotide polymorphisms (SNPs) of PDCD1, CD274, and HAVCR2 genes with the risk and outcomes of non-small cell lung cancer (NSCLC) subtypes: squamous cell lung cancer (LUSC) and lung adenocarcinoma (LUAD).

Methods
TaqMan SNP genotyping assays or polymerase chain reaction-restriction fragment length polymorphism methods were used to determine genotypes of: PDCD1: rs36084323, rs7421861, rs11568821, rs2227981, rs10204525; CD274: rs822335, rs10815225, rs17718883, rs2297136, rs4742098, rs4143815; HAVCR2: rs10057302, rs1036199. Among 383 NSCLC patients, 112 were diagnosed with LUAD and 116 with LUSC. The control group consisted of 433 unrelated, cancer-free subjects.

Results
A CC genotype of rs4143815 and GG genotype of rs4742098 were associated with two times higher risk of developing LUSC (CC vs. GG + GC, OR = 2.31; 95% CI = 1.32, 4.06; P = 0.003; GG vs. AA + AG, OR = 2.26; 95% CI = 1.17, 4.36; P = 0.016, respectively). Moreover, rs4143815 was an independent predictor of the age at diagnosis of LUAD. The carriers of C allele were diagnosed 4.81 years later (95% CI = 1.47, 8.15; P = 0.006) than patients with the GG genotype. The rs10057302 CA genotype was an independent predictor of overall survival in LUSC (adjusted HR = 0.13; 95% CI = 0.02, 0.93; P = 0.043). NSCLC carriers of rs11568821 T allele had almost double the risk of death (adjusted HR = 2.05; 95% CI = 1.28, 3.29; P = 0.003) compared to carriers of CC genotype.

Conclusions
Our results provided additional evidence that SNPs of genes for PD-1, PD-L1 and TIM-3 differentially modulate the risk and prognosis of LUSC and LUAD.
Force-based assessment of tissue handling skills in simulation training for robot-assisted surgery
Authors: Rahimi A. Masie , Hardon Sem F. , Willuth E. , Lang F. , Haney Caelan M. , Felinska Eleni A. , Kowalewski Karl-Friedrich , Müller-Stich Beat P. , Horeman Tim , Nickel F. , Daams Freek 
Published: February 2023

Abstract
Introduction
Although robotic-assisted surgery is increasingly performed, objective assessment of technical skills is lacking. The aim of this study is to provide validity evidence for objective assessment of technical skills for robotic-assisted surgery.

Methods
An international multicenter study was conducted with participants from the academic hospitals Heidelberg University Hospital (Germany, Heidelberg) and the Amsterdam University Medical Centers (The Netherlands, Amsterdam). Trainees with distinctly different levels of robotic surgery experience were divided into three groups (novice, intermediate, expert) and enrolled in a training curriculum. Each trainee performed six trials of a standardized suturing task using the da Vinci Surgical System. Using the ForceSense system, five force-based parameters were analyzed, for objective assessment of tissue handling skills. Mann–Whitney U test and linear regression were used to analyze performance differences and the Wilcoxon signed-rank test to analyze skills progression.

Results
A total of 360 trials, performed by 60 participants, were analyzed. Significant differences between the novices, intermediates and experts were observed regarding the total completion time (41 s vs 29 s vs 22 s p = 0.003), mean non zero force (29 N vs 33 N vs 19 N p = 0.032), maximum impulse (40 Ns vs 31 Ns vs 20 Ns p = 0.001) and force volume (38 N3 vs 32 N3 vs 22 N3p = 0.018). Furthermore, the experts showed better results in mean non-zero force (22 N vs 13 N p = 0.015), maximum impulse (24 Ns vs 17 Ns p = 0.043) and force volume (25 N3 vs 16 N3p = 0.025) compared to the intermediates (p ≤ 0.05). Lastly, learning curve improvement was observed for the total task completion time, mean non-zero force, maximum impulse and force volume (p ≤ 0.05).

Conclusion
Construct validity for force-based assessment of tissue handling skills in robot-assisted surgery is established. It is advised to incorporate objective assessment and feedback in robot-assisted surgery training programs to determine technical proficiency and, potentially, to prevent tissue trauma.
Green functions for three-point boundary value problems governed by differential equation systems with applications to Timoshenko beams
Authors: Kiss L. P. , Szeidl G. 
Published: February 2023

AbstractThe present paper is devoted to the issue of the Green function matrices that belongs to some three-point boundary- and eigenvalue problems. A detailed definition is given for the Green function matrices provided that the considered boundary value problems are governed by a class of ordinary differential equation systems associated with homogeneous boundary and continuity conditions. The definition is a constructive one, i.e., it provides the means needed for calculating the Green function matrices. The fundamental properties of the Green function matrices—existence, symmetry properties, etc.—are also clarified. Making use of these Green functions, a class of three-point eigenvalue problems can be reduced to eigenvalue problems governed by homogeneous Fredholm integral equation systems. The applicability of the novel findings is demonstrated through a Timoshenko beam with three supports.
A technology transfer journey to a model-driven access control system
Authors: De Sanctis Martina , Di Salle Amleto , Iovino Ludovico , Rossi Maria Teresa 
Published: February 2023

AbstractIn the model-driven security domain, access control systems provide an application for handling access of persons through controlled gates. A gate, such as a door, can have a lock mechanism for securing the area from unauthorized access. Most commercial solutions for access control management offer pre-packaged software systems where customization of the authorization logic is either not allowed or subject to payment. Moreover, cross-platform development is a barrier for solution providers due to the high cost of development and maintenance that it implies. To overcome these limitations and further optimize the entire access control systems development process, we propose a model-driven approach that supports automatic code generation to enable communication between an IoT infrastructure and platforms for Facility Access Management. Specifically, the approach combines the benefits of Near-Field Communication (NFC) and Tinkerforge (i.e., an open-source hardware platform) with model-driven techniques. This allows the approach to exploit both behavioral and structural models for the modeling and the consequent code generation of part of the authorization mechanism, thus providing complete coverage of the code generated for the whole system. We implemented and evaluated our approach in a real-world case study within the premises of a fitness center with an IoT infrastructure consisting of several heterogeneous sensors by showing its practical applicability. Experimental results demonstrate the effectiveness of our approach in supporting abstraction and automation concerning traditional code-centric development through code generation features. Consequently, our approach makes the whole development process less time-consuming and error-prone, thus reducing the system’s time to market.
Bounds for the Diameters of Orbital Graphs of Affine Groups
Authors: Maróti Attila , Skresanov Saveliy V. 
Published: February 2023

AbstractGeneral bounds are presented for the diameters of orbital graphs of finite affine primitive permutation groups. For example, it is proved that the orbital diameter of a finite affine primitive permutation group with a nontrivial point stabilizerH≤GL(V), where the vector spaceVhas dimensiondover the prime field, can be bounded in terms ofdand$\log |V|/\log |H|$log|V|/log|H|only. Several infinite families of affine primitive permutation groups with large orbital diameter are constructed. The results are independent from the classification of finite simple groups.
New error estimates of Lagrange–Galerkin methods for the advection equation
Authors: Bermejo Rodolfo , Carpio Jaime , Saavedra Laura 
Published: February 2023

AbstractWe study in this paper new developments of the Lagrange–Galerkin method for the advection equation. In the first part of the article we present a new improved error estimate of the conventional Lagrange–Galerkin method. In the second part, we introduce a new local projection stabilized Lagrange–Galerkin method, whereas in the third part we introduce and analyze a discontinuity-capturing Lagrange–Galerkin method. Also, attention has been paid to the influence of the quadrature rules on the stability and accuracy of the methods via numerical experiments.
Fight outcome influences male mating success in Drosophila prolongata
Authors: Toyoshima Naoki , Matsuo Takashi 
Published: February 2023

AbstractThe outcomes of preceding fights can influence the probability of winning a subsequent fight, known as the winner/loser effect. However, we know relatively little about how the experience of a preceding fight influences subsequent mating success. Here, we investigated the influence of preceding fight outcomes on subsequent mating behavior in a fruit fly Drosophila prolongata. Subordinate males mated less in two-choice mating assays, showing that the fight outcome predicts male mating success in this species. This tendency remained in a no-choice mating assay where direct interaction between the dominant and subordinate males was eliminated, suggesting that the mating disadvantage of the subordinate males was dependent on the experience of the previous fight rather than the direct interference by the dominant male. When a no-choice mating assay was performed before the fight, the prospective subordinate males mated at the same rate as the dominant males, confirming that the intrinsic male qualities in fighting and mating performances were independent of each other in our experiments. These results indicated that the experience-dependent changes in the subordinate males led to the reduced mating success.
Deindustrialisierung, Transformation und eine moderne Industriepolitik
Authors: Brandt Arno , Krämer Hagen 
Published: February 2023

AbstractIn the medium to long term, the manufacturing sector faces considerable challenges due to the necessary digital and ecological transformation as well as the new geopolitical situation. The new general conditions require an industrial and innovation policy oriented towards sustainability, climate neutrality and technological sovereignty. The successful implementation of the transformation processes makes sustainable changes necessary. This requires a new structural, innovation and industrial strategic policy that sets socio-political goals and launches the necessary innovations with the appropriate instruments.