bluuebunny/crossref_metadata_2025_split huggingface dataset:
The onset of late severe lung impairment in COVID-19 is associated with high inflammation markers at admission and metabolic syndrome markers
Authors: Epaulard Olivier , Le Gouellec Audrey , Le Marechal Marion , Nemoz Benjamin , Borel Anne-Laure , Dartevel Anaïs , Gheerbrant Hubert , Herault Marie-Christine , Bosseray Annick , Clavarino Giovanna , Lupo Julien , Viglino Damien , Quenard Fanny , Candille Clara , Camara Boubou , Durand Michel , Faure Patrice , Guergour Dorra , Chidlovski Elena , Jacob Marie-Christine , Larrat Sylvie , Froidure Marie , Terzi Nicolas , Quetant Sébastien , Payen Jean-François , Colombe Barbara , Raskovalova Tatiana , Morand Patrice , Pierre Isabelle , Schwebel Carole , Hamidfar Rebecca , Bouillet Laurence , Brion Jean-Paul , Trocme Candice , Berthier Sylvie , Chirica Carole , Mounayar Anne-Laure , Blanc Myriam , Pavese Patricia , Toussaint Bertrand 
Published: December 2022

AbstractBackgroundCOVID-19 severity is mainly related to lung impairment. However, preexisting patient characteristics and biomarkers at admission associated with this event are not precisely known.MethodsWe report 205 patients admitted for a proven COVID-19 in our institution between March 7 and April 22, 2020, particularly their comorbidities, respiratory severity, immune profile, and metabolic profile.FindingsMedian age was 70 years [interquartile range (IQR) 25-75: 60;79]; 115 (56·1%) patients were men. Oxygen supplementation of >2L/min was required in 107 patients (52·2%) after a median time of 8 days [IQR: 6;10] after the first symptoms; 67 (32·7%) patients were admitted to the intensive care unit (ICU), almost exclusively due to severe hypoxia. Patients requiring >2L/min oxygen therapy and/or ICU admission were older and more frequently males, with a significantly higher body mass index (BMI), a significantly higher total cholesterol (TC) / HDL cholesterol ratio, and higher triglycerides. They also had higher plasma levels of C-reactive protein (CRP) and interleukin 6 (IL-6); IL-6 >20 ng/L and CRP >70 mg/L were significantly associated with ICU admission and/or (for patients with a decision of limitation of life-support therapy) death. Higher BMI and TC/HDL-c ratio were associated with higher CRP and IL-6 levels. Steroid therapy was performed in 61 patients; while its clinical impact was inconclusive due to heterogeneous situations, IL-6 levels decreased significantly more in these patients.InterpretationSevere COVID-19 mostly relates to late-onset pneumonia associated with preexisting metabolic syndrome markers and a surge in inflammatory markers, allowing the early identification of at-risk patients.FundingThis work was supported by Foundation University of Grenoble Alpes.
Machine Learning Classification Of Autism Spectrum Disorder Based On Reciprocity In Naturalistic Social Interactions
Authors: Koehler J.C. , Dong M.S. , Nelson A.M. , Fischer S. , Späth J. , Plank I.S. , Koutsouleris N. , Falter-Wagner C.M. 
Published: December 2022

AbstractAutism spectrum disorder is characterized by impaired social communication and interaction. As a neurodevelopmental disorder typically diagnosed during childhood, diagnosis in adulthood is preceded by a resource-heavy clinical assessment period. The ongoing developments in digital phenotyping give rise to novel opportunities within the screening and diagnostic process. In this study, we investigated videos of naturalistic social interaction between autistic and non-autistic adults on their predictiveness for autistic behaviors. Non-autistic control participants were either paired with each other or an autistic participant to engage in two conversational tasks. We used existing computer vision algorithms to extract information based on the synchrony of movement and facial expression. These were subsequently used as features in a support vector machine learning model to predict interaction dyad membership. Results showed high predictive accuracy of synchrony in facial movements, underlining the distinctive nature of non-verbal behavior in autism and its feasibility for digitalized assessment.
Data-driven estimation of the instantaneous reproduction number and growth rates for the 2022 monkeypox outbreak in Europe
Authors: Saldaña Fernando , Daza-Torres Maria L. , Aguiar Maíra 
Published: December 2022

AbstractObjectiveTo estimate the instantaneous reproduction numberRtand the epidemic growth rates for the 2022 monkeypox outbreaks in the European region.MethodsWe gathered daily laboratory-confirmed monkeypox cases in the most affected European countries from the beginning of the outbreak to September 23, 2022. A data-driven estimation of the instantaneous reproduction number is obtained using a novel filtering type Bayesian inference. A phenomenological growth model coupled with a Bayesian sequential approach to update forecasts over time is used to obtain time-dependent growth rates in several countries.ResultsThe instantaneous reproduction numberRtfor the laboratory-confirmed MPX cases in Spain, France, Germany, the UK, the Netherlands, Portugal, and Italy. At the early phase of the outbreak, our estimation forRt, which can be used as a proxy for the basic reproduction numberR0, was 2.32 (95% CI 1.81−3.05) for Spain, 2.91 (95% CI 2.33−3.52) for France, 1.84 (95% CI 1.55−2.31) for UK, 3.16 (95% CI 2.55−3.64) for Germany, 2.97 (95% CI 2.01−4.32) for the Netherlands, 1.18 (95% CI 0.98−1.33) for Portugal, 3.74 (95% CI 2.91−4.49) for Italy. Cumulative cases for these countries present subexponential rather than exponential growth dynamics.ConclusionsOur findings suggest that the current monkeypox outbreaks present limited transmission chains of human-to-human secondary infection so the possibility of a huge pandemic is very low. Confirmed monkeypox cases are decreasing significantly in the European region, the decline might be attributed to public health interventions and behavioral changes in the population due to increased risk perception. Nevertheless, further strategies toward elimination are essential to avoid the subsequent evolution of the monkeypox virus that can result in new outbreaks.
Modeling IP3induced Ca2+signaling based on its interspike interval statistics
Authors: Friedhoff Victor Nicolai , Falcke Martin 
Published: December 2022

AbstractInositol 1,4,5-trisphosphate (IP3) induced Ca2+signaling is a second messenger system used by almost all eukaryotic cells. Recent research identified 8 general properties of Ca2+spiking common to all cell types investigated and demonstrated randomness of Ca2+signaling on all structural levels. We suggest a theory of Ca2+spiking starting from the random behaviour of IP3receptor channel clusters mediating the release of Ca2+from the endoplasmic reticulum. Spike generation begins after the absolute refractory period of the previous spike. According to its hierarchical spreading from initiating channel openings to cell level, we describe it as a first passage process from none to all clusters open while the cell recovers from the inhibition which terminated the previous spike. Our theory reproduces quantitatively all general properties for different IP3pathways including the exponential stimulation response relation of the average interspike interval (ISI) Tavand its robustness properties, random spike timing with a linear moment relation between Tavand the ISI standard deviation and its robustness properties, sensitive dependency of Tavon diffusion properties, and non-oscillatory local dynamics. We explain large cell variability of Tavobserved in experiments by variability of channel cluster coupling by Ca2+induced Ca2+release, the number of clusters and IP3pathway components expression levels. We predict the relation between puff probability and agonist concentration, and [IP3] and agonist concentration. Differences of spike behaviour between cell types and stimulating agonists are explained by the different types of negative feedback terminating spikes. In summary, the hierarchical random character of spike generation explains all of the identified general properties.
Status and future perspectives for pikeperch (Sander lucioperca) stocks in Europe
Authors: Jakubavičiūtė Eglė , Arula Timo , Dainys Justas , Deweber J. Tyrell , Gorfine Harry , Härkönen Laura S. , Hyvärinen Pekka , Hommik Kristiina , Kubecka Jan , Ložys Linas , Mustamäki Noora , Naddafi Rahmat , Olin Mikko , Pūtys Žilvinas , Sepp Elor , Souza Allan T. , Šiaulys Andrius , Vaino Väino , Audzijonyte Asta 
Published: December 2022

AbstractPikeperch (Sander lucioperca) is a European fresh and brackish water piscivorous fish, important as both a key predator and a valuable commercial and recreational fisheries species. There are concerns that some stocks are depleted due to overfishing and environmental changes. We review data collection and population assessments currently used for nine pikeperch stocks across six European countries and apply a unified assessment framework to evaluate population status and trends. For this we first standardised commercial, scientific, and recreational catch-per-unit-effort (CPUE) and catch time series and then applied Bayesian surplus production models. Our results showed that three stocks (including two in the Baltic Sea) were strongly depleted, with estimated biomasses considerably lower than the biomass at maximum sustainable yield (Bmsy). Other stocks were either close or higher than their estimated Bmsy. Looking at the trends, we find that four stocks (Lake Oulujärvi, Kvädöfjärden, Lake Peipsi and Lipno) showed increasing biomass trends and two (Curonian Lagoon, Galtfjärden) had a strong decline in biomass. In most cases the stocks with clear signs of recovery were also those for which strong management strategies have been implemented. We find that, despite pikeperch being one of the most valuable inland fisheries, formalised stock assessments and regular surveys remain rare. Importantly, although most stocks are strongly targeted by recreational fishing, estimates of recreational catch are highly uncertain. We conclude that data limited stock assessment methods are useful for assessing fish population status and highlight an urgent need to improve pikeperch scientific monitoring and assessment of recreational catches.
Genetic load and adaptive potential of a recovered avian species that narrowly avoided extinction
Authors: Femerling Georgette , van Oosterhout Cock , Feng Shaohong , Bristol Rachel M. , Zhang Guojie , Groombridge Jim , Gilbert M. Thomas P. , Morales Hernán E. 
Published: December 2022

AbstractHigh genetic diversity is often a good predictor of long-term population viability, yet some species persevere despite having low genetic diversity. Here we study the genomic erosion of the Seychelles paradise flycatcher (Terpsiphone corvina), a species that narrowly avoided extinction after having declined to 28 individuals in the 1960s. The species recovered unassisted to over 250 individuals in the 1990s and was downlisted from Critically Endangered to Vulnerable in the IUCN Red List in 2020. By comparing historical, pre-bottleneck (130+ years old) and modern genomes, we uncovered a 10-fold loss of genetic diversity. The genome shows signs of historical inbreeding during the bottleneck in the 1960s, but low levels of recent inbreeding after the demographic recovery. We show that the proportion of severely deleterious mutations has reduced in modern individuals, but mildly deleterious mutations have remained unchanged. Computer simulations suggest that the Seychelles paradise flycatcher avoided extinction and recovered due to its long-term small Ne. This reduced the masked load and made the species more resilient to inbreeding. However, we also show that the chronically small Neand the severe bottleneck resulted in very low genetic diversity in the modern population. Our simulations show this is likely to reduce the species’ adaptive potential when faced with environmental change, thereby compromising its long-term population viability. In light of rapid global rates of population decline, our work highlights the importance of considering genomic erosion and computer modelling in conservation assessments
Professional shariah audit training via the e-learning approach during COVID-19: challenges and prospects
Authors: Kamaruddin Muhammad Iqmal Hisham , Hanefah Mustafa Mohd 
Published: December 2022

PurposeThis study aims to explore and identify potential challenges and prospects for conducting the professional shariah audit training programme via an e-learning approach during coronavirus disease 2019 (COVID-19).Design/methodology/approachQuestionnaires were administered to 296 participants who were enrolled in the professional shariah audit training programme via e-learning during the COVID-19 pandemic outbreak in 2020. These participants were final-year students from selected Malaysian public universities.FindingsFindings show that several main challenges are faced in adopting an e-learning approach for conducting the professional shariah audit training programme such as the inability to do more hands-on, group and physical activities, different understandings based on academic backgrounds, difficulty in learning practical and technical topics, technical issues and problems during e-learning sessions. These lead to the unsuitability of conducting professional training via the e-learning approach. In terms of prospects of knowledge learnt via the e-learning approach, participants showed that they are able to master all six modules covered in the professional shariah audit training programme via the e-learning approach. These include (1) shariah principles; (2) shariah governance; (3) Islamic financial transactions; (4) shariah risk management; (5) shariah audit planning and programme; and (6) shariah audit fieldwork and communication.Practical implicationsBased on the findings, it is suggested to have more time spent and earlier preparation on the learning contents and sessions, more discussion on actual contents and practical exercises and competency of the trainers in delivering e-learning sessions.Originality/valueThis study is believed to be one among the pioneering studies on the potential challenges and prospects in adopting e-learning for conducting the professional shariah audit training programme due to COVID-19.
Testing of coherence between monetary policy stimulus, financial flexibility and profitability of manufacturing firms
Authors: Panda Ajaya Kumar , Nanda Swagatika , Hegde Apoorva 
Published: December 2022

PurposeThis paper aims to empirically investigate the evidence of the transmission of monetary policy impulses to firm profitability via manufacturing firms’ short-term and long-term corporate financing decisions.Design/methodology/approachThis study decomposes the receptiveness of firm profitability to monetary policy shock under circumstances of financial flexibility. Additionally, the study extends its scope to undertake a sector-wise analysis of manufacturing firms from 2008 to 2020. Generalized methods of moments (GMM) and quantile regression models are employed.FindingsThe profitability of firms in the chemical, food and machinery sector are positively impacted by short-term financing, whereas the metal sector is positively impacted. But during the tight monetary policy, short-term financing does not appear to be a significant parameter while explaining the firms’ profitability. Secondly, the profitability of firms in the consumer goods and metal sector is positively impacted by long-term financing. Therefore, debt financing of assets could be more appropriate to maximize profitability in these sectors.Originality/valueAnalyzing the transmission of monetary policy impulses to firm profitability by clustering firms with financial flexibility across six key manufacturing sectors makes the study unique.
Challenges and opportunities of SRI sukuk toward financial system sustainability: a bibliometric and systematic literature review
Authors: Delle Foglie Andrea , Keshminder J.S. 
Published: December 2022

PurposeThe main objective of this paper is to analyze works of literature on SRI sukuk to highlight the potential for these kinds of instruments in financing more sustainable financial systems (SFSs). The analysis mainly accentuates a dearth of knowledge on the various challenges and opportunities in the realm of SRI.Design/methodology/approachThis paper pioneers the bibliometric and systematic literature review of the development of the SRI sukuk from 2016 (the first available year in the field) to and 2021.FindingsThe study findings highlighted several pertinent SRI issues: the lack of standardization due to the different interpretations of Shariah and green, the lack of retail investors, which inevitably produce a lack of liquidity in the secondary market, thus limiting their growth, its funding allocation’ close resemblance to green financing, and the role of Malaysia and Indonesia as global sustainable financial hubs to stimulate the development of Shariah-compliant sustainable instruments and contribute to the international debate about the building of a global standardized framework related to sustainable investments.Originality/valueThe integration of the environmental principles of a green bond with the Shariah-compliant financial structure of a sukuk, the SRI sukuk, represents a vital crossroad in both sustainable and Islamic finance. Social-impact sukuk and green sukuk is an undervalued instrument that could play an important role in financing a more sustainable economic and financial system, including Islamic investing. This kind of instruments, which is based on a “pay for success” principle in the conventional layout, perfectly fit with the profit-and-lost sharing’s (PLS's) ethicality, the sustainability principles of Islamic finance and the religious principles of Islamic law.
A bibliometric analysis of the first 20 years of the Journal of Corporate Real Estate
Authors: Maggon Mohita 
Published: December 2022

Purpose
Journal of Corporate Real Estate (JCRE) is an international journal of repute. JCRE is an interdisciplinary journal focusing on corporate real estate management and caters to the needs of real estate owners and end-users. The journal's scope includes private and public sector corporate real estate owned and used by businesses to run their operations. This paper aims to analyze the journal's impact using bibliometric analysis from 1998 to 2017 on 380 publications.

Design/methodology/approach
The network analysis is performed using VOSviewer software and Biblioshiny R studio. The mapping presents citation structures, coauthorship patterns, bibliographic coupling and other network analyses.

Findings
The results show that the journal is growing in terms of citations and impact. The findings document various mapping criteria and their summaries. Seven major clusters are identified to delineate the underlying themes of publications in JCRE.

Originality/value
To the best of the authors’ knowledge, this paper offers the original and first bibliometric analysis of the journal’s impact over the first two decades. The findings are relevant for researchers and real estate stakeholders.
Revealing the factors of re-patronage intention: true behavioral insights in hotel customers
Authors: Badar (Imran) Sarah , Waheed Ajmal 
Published: December 2022

PurposeThe rapid shift in the emerging pedagogies of customer behavior has changed the business preferences in the hotel sector. This study prioritizes the hotel's main task to develop customer re-patronage intention. Keeping in line with these factors, this study investigates the impact of customer empowerment on re-patronage intentions through customer value co-creation in the hotel sector of Pakistan. Furthermore, the study examines the moderating impact of sensation-seeking on customers.Design/methodology/approachA total of 350 potential customers participated in the online survey using purposive and snowball sampling techniques. Partial least square structural equation modeling was employed using Smart PLS-3 to test the projected hypotheses.FindingsThis study reveals that empowered customers improve their behavior and involvement in value co-creation, which, in turn, increases the prospects of re-patronage intention. Moreover, sensation-seeking moderates between consumer empowerment and customer value co-creation.Research limitations/implicationsCustomer-dominant logic and sense-making theory present interesting insights where customer empowerment and value co-creation have a positively significant impact on customer re-patronage intention. Findings also elaborate on a significant mediating role of customer value co-creation activities, which is an interesting call for hotel managers to add thought-sharing ecosystems. The suggested factors add long-lasting results in terms of revenues, performance and global GDP.Practical implicationsIt provides guidance for the hotel managers through novel factors that activate the customer to augment an intention to re-patron. Moreover, it provides a direction to add sensation-seeking strategies that strengthen the effects on customer empowerment and value co-creation.Originality/valueThis study has its uniqueness in introducing an environment in hotels where customers are empowered to further actively participate in value co-creation initiatives, along with sensation-seeking acting as a stimulus among them. These factors have greatly impacted the hotel's objectives (i.e. re-patronage intention).
External business knowledge transmission: a conceptual framework
Authors: Labas Alan , Courvisanos Jerry 
Published: December 2022

Purpose
This study aims to develop an original conceptual framework to guide research into knowledge transmission between professional external knowledge providers and their business clientele. As such, the framework aims to bridge a gap between theory and practice by explicating the processes which affect knowledge transmission and the conversion of knowledge for business application (i.e. knowledge transference).

Design/methodology/approach
Key concepts from disciplines of knowledge management, information management, communications, services marketing and business advice are reviewed and integrated into the development of this framework. Underpinned by a critical realist philosophical lens, it provides a robust research guide for examining business advisor knowledge actions in a changing open environment.

Findings
This study identifies that the process of knowledge transmission from a source external to a business is more complex than internal knowledge sharing. It addresses this complexity through a knowledge transmission framework, in a research design that is applicable to any methodological paradigm. Real-world application is identified in its applicability for evaluating mechanisms to facilitate knowledge transmission practices of external advisors to small business in regionally isolated communities.

Research limitations/implications
The critical realist research methodology allows for causality in knowledge transmission to emerge; however, no assertion is made that the conceptual framework developed needs any particular philosophical paradigm for its application. Instead, what is asserted is that the research framework developed in this paper is specifically suited to the characteristics of external knowledge providers, their tacit knowledge and the businesses they service.

Originality/value
This study reconceptualises various theoretical perspectives and develops a sequential process for addressing a research lacuna by specifically examining the processes (or connections) between external business advisor’s knowledge and their advisory actions. With these processes clearly established, the role of external knowledge providers, as knowledge transmitters, deepens the understanding of knowledge transference that up until now has focused typically on internal organisation aspects.