bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topography of respiratory tract and gut microbiota in mice with influenza A virus infection
Authors: Chen Qichao , Liu Manjiao , Lin Yanfeng , Wang Kaiying , Li Jinhui , Li Peihan , Yang Lang , Jia Leili , Zhang Bei , Guo Hao , Li Peng , Song Hongbin 
Published: February 2023

IntroductionInfluenza A virus (IAV)-induced dysbiosis may predispose to severe bacterial superinfections. Most studies have focused on the microbiota of single mucosal surfaces; consequently, the relationships between microbiota at different anatomic sites in IAV-infected mice have not been fully studied.MethodsWe characterized respiratory and gut microbiota using full-length 16S rRNA gene sequencing by Nanopore sequencers and compared the nasopharyngeal, oropharyngeal, lung and gut microbiomes in healthy and IAV-infected mice.ResultsThe oropharyngeal, lung and gut microbiota of healthy mice were dominated by Lactobacillus spp., while nasopharyngeal microbiota were comprised primarily of Streptococcus spp. However, the oropharyngeal, nasopharyngeal, lung, and gut microbiota of IAV-infected mice were dominated by Pseudomonas, Escherichia, Streptococcus, and Muribaculum spp., respectively. Lactobacillus murinus was identified as a biomarker and was reduced at all sites in IAV-infected mice. The microbiota composition of lung was more similar to that of the nasopharynx than the oropharynx in healthy mice.DiscussionThese findings suggest that the main source of lung microbiota in mice differs from that of adults. Moreover, the similarity between the nasopharyngeal and lung microbiota was increased in IAV-infected mice. We found that IAV infection reduced the similarity between the gut and oropharyngeal microbiota. L. murinus was identified as a biomarker of IAV infection and may be an important target for intervention in post-influenza bacterial superinfections.
Role of cognitive reserve in ischemic stroke prognosis: A systematic review
Authors: Tao Chunhua , Yuan Yuan , Xu Yijun , Zhang Song , Wang Zheng , Wang Sican , Liang Jingyan , Wang Yingge 
Published: February 2023

ObjectiveThis systematic review was performed to identify the role of cognitive reserve (CR) proxies in the functional outcome and mortality prognostication of patients after acute ischemic stroke.MethodsPubMed, Embase, Web of Science, and Cochrane Library were comprehensively searched by two independent reviewers from their inception to 31 August 2022, with no restrictions on language. The reference lists of reviews or included articles were also searched. Cohort studies with a follow-up period of ≥3 months identifying the association between CR indicators and the post-stroke functional outcome and mortality were included. The outcome records for patients with hemorrhage and ischemic stroke not reported separately were excluded. The Quality In Prognosis Studies (QUIPS) tool was used to assess the quality of included studies.ResultsOur search yielded 28 studies (n = 1,14,212) between 2004 and 2022, of which 14 were prospective cohort studies and 14 were retrospective cohort studies. The follow-up period ranged from 3 months to 36 years, and the mean or median age varied from 39.6 to 77.2 years. Of the 28 studies, 15 studies used the functional outcome as their primary outcome interest, and 11 of the 28 studies included the end-point interest of mortality after ischemic stroke. In addition, two of the 28 studies focused on the interest of functional outcomes and mortality. Among the included studies, CR proxies were measured by education, income, occupation, premorbid intelligence quotient, bilingualism, and socioeconomic status, respectively. The quality of the review studies was affected by low to high risk of bias.ConclusionBased on the current literature, patients with ischemic stroke with higher CR proxies may have a lower risk of adverse outcomes. Further prospective studies involving a combination of CR proxies and residuals of fMRI measurements are warranted to determine the contribution of CR to the adverse outcome of ischemic stroke.Systematic review registrationPROSPERO, identifier CRD42022332810, https://www.crd.york.ac.uk/PROSPERO/.
Enhanced intrinsic functional connectivity in the visual system of visual artist: Implications for creativity
Authors: Hong Tzu-Yi , Yang Ching-Ju , Shih Chung-Heng , Fan Sheng-Fen , Yeh Tzu-Chen , Yu Hsin-Yen , Chen Li-Fen , Hsieh Jen-Chuen 
Published: February 2023

IntroductionThis study sought to elucidate the cognitive traits of visual artists (VAs) from the perspective of visual creativity and the visual system (i.e., the most fundamental neural correlate).MethodsWe examined the local and long-distance intrinsic functional connectivity (FC) of the visual system to unravel changes in brain traits among VAs. Twenty-seven university students majoring in visual arts and 27 non-artist controls were enrolled.ResultsVAs presented enhanced local FC in the right superior parietal lobule, right precuneus, left inferior temporal gyrus (ITG), left superior parietal lobule, left angular gyrus, and left middle occipital gyrus. VAs also presented enhanced FC with the ITG that targeted the visual area (occipital gyrus and cuneus), which appears to be associated with visual creativity.DiscussionThe visual creativity of VAs was correlated with strength of intrinsic functional connectivity in the visual system. Learning-induced neuroplasticity as a trait change observed in VAs can be attributed to the macroscopic consolidation of consociated neural circuits that are engaged over long-term training in the visual arts and aesthetic experience. The consolidated network can be regarded as virtuoso-specific neural fingerprint.
Comparing efficacy and safety of first-line treatment of metastatic renal cell carcinoma: A Bayesian network meta-regression analysis
Authors: Qin Suyang , Xv Zhiyuan , Chen Xi , Wang Shurui , Lu Hai , Li Jiaqi , Guo Xinglin , Yang Jinghua , Liu Chengjiang , Wang Yaoguang , Wang Hongwu 
Published: February 2023

BackgroundThis Bayesian network meta-regression analysis provides a head-to-head comparison of first-line therapeutic immune checkpoint inhibitors (ICI) and tyrosine kinase inhibitors (TKI) combinations for metastatic renal cell carcinoma (mRCC) using median follow-up time as covariate.MethodsWe searched Six databases for a comprehensive analysis of randomised clinical trials (RCTs). Comparing progression free survival (PFS) and overall survival (OS) of different interventions at the same time node by Bayesian network meta-analysis. Bayesian network meta-regression analysis was performed on objective response rate (ORR), adverse events (AEs) (grade ≥ 3) and the hazard ratios (HR) associated with PFS and OS, with the median follow-up time as the covariate.ResultsEventually a total of 22 RCTs reporting 11,090 patients with 19 interventions. Lenvatinib plus Pembrolizumab (LenPem) shows dominance of PFS, and Pembrolizumab plus Axitinib (PemAxi) shows superiority in OS at each time point. After meta-regression analysis, for HRs of PFS, LenPem shows advantages; for HRs of OS, PemAxi shows superiority; For ORR, LenPem provides better results. For AEs (grade ≥ 3), Atezolizumab plus Bevacizumab (AtezoBev) is better.ConclusionConsidering the lower toxicity and the higher quality of life, PemAxi should be recommended as the optimal therapy in treating mRCC.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD4202236775.
Development of A novel ferroptosis-related prognostic signature with multiple significance in paediatric neuroblastoma
Authors: Wang Xin , Yang Jun , Bian Hongqiang , Yang Hu 
Published: February 2023

BackgroundFerroptosis is an iron-dependent regulated cell death pathway that plays an essential role in the occurrence and development of tumours. Nonetheless, little is known about the impact of ferroptosis-related genes (FRGs) on neuroblastoma.MethodsTranscriptional profiles and clinicopathological data of neuroblastoma were downloaded from the TARGET and GEO datasets. These were used as the training set and the validation set, respectively. Non-negative matrix factorisation was employed to divide patients with neuroblastoma into distinct ferroptosis clusters. The Cox regression model with LASSO was performed based on the FRGs to construct a multigene signature, which was subsequently evaluated in the testing set. Finally, we analysed the differences in the tumour immune microenvironment (TIME) and immunotherapeutic response among the different risk groups.ResultsThe two distinct ferroptosis subtypes were determined and correlated with different clinical outcomes and tumour-infiltrating immune cells (TIICs). A risk model was developed to explore the risk scores of the individual patients. Patients in the low-risk group survived significantly longer than those in the high-risk group and showed a good predictive performance in the testing set. The risk score was significantly linked to clinicopathological traits, and it was confirmed as an independent prognostic indicator for assessing the overall survival. We also found that patients with low-risk scores had a higher infiltration of TIICs and a better immunotherapeutic response.ConclusionsThis study showed the potential role of FRGs in contributing to the clinical features, prognosis, TIME, and immunotherapy of neuroblastoma cases. Our findings offer a valuable basis for future research in targeting ferroptosis and its TIME and provide novel measures for the prevention and treatment of neuroblastoma.
PBPK modeling to evaluate maximum tolerated doses: A case study with 3-chloroallyl alcohol
Authors: Conolly Rory P. , Clewell Harvey J. , Moore Martha M. , Campbell Jerry L. , Cheng Wanyun , Gentry R. Robinan 
Published: February 2023

Introduction: A physiologically based pharmacokinetic (PBPK) model for 3-chloroallyl alcohol (3-CAA) was developed and used to evaluate the design of assays for the in vivo genotoxicity of 3-CAA.Methods: Model development was supported by read across from a published PBPK model for ethanol. Read across was motivated by the expectation that 3-CAA, which like ethanol is a primary alcohol, is metabolized largely by hepatic alcohol dehydrogenases. The PBPK model was used to evaluate how two metrics of tissue dosimetry, maximum blood concentration (Cmax; mg/L) and area under the curve (AUC; mg-hr/L) vary with dose of 3-CAA and with dose route (oral gavage, drinking water).Results: The model predicted that oral gavage results in a 6-fold higher Cmax than the same dose administered in drinking water, but in similar AUCs. Predicted Cmax provided the best correlation with severe toxicity (e.g., lethality) from 3-CAA, consistent with the production of a reactive metabolite. Therefore, drinking water administration can achieve higher sustained concentration without severe toxicity in vivo.Discussion: This evaluation is significant because cytotoxicity is a potential confounder of mutagenicity testing. The PBPK model can be used to ensure that studies meet OECD and USEPA test guidelines and that the highest dose used is not associated with severe toxicity. In addition, PBPK modeling provides assurance of target tissue (e.g., bone marrow) exposure even in the absence of laboratory data, by defining the relationship between applied dose and target tissue dose based on accepted principles of pharmacokinetics, relevant physiology and biochemistry of the dosed animals, and chemical-specific information.
The impact of internet use on health status among older adults in China: The mediating role of social support
Authors: E Yiting , Yang Jianke , Niu Long , Lu Chunli 
Published: February 2023

BackgroundWith the popularization of the Internet, the use of the Internet is becoming more and more important in the daily life of older adults. However, previous research mainly focuses on Internet use and health in general, and the mechanism of this effect remains to be studied. To bridge this gap, this study aims to explore the mediational effects of social support between Internet use and health among older adults in China.MethodsThe data used in this article are from the 2021 Chinese General Social Survey (CGSS). Social support is divided into two aspects and four dimensions: informal social support (relatives support, friends support, neighbors support) and formal social support (social insurance). This article uses the nested multivariate OLS regression models to analyze the impact of Internet use on health. Furthermore, Finally, SPSS macro PROCESS is applied to test their mediation effects.ResultsInformal social support positively influenced the health status among older adults, while formal social support did not. Among the three types of informal social support, relatives support and friends support significantly affected health status among Chinese older adults. Regarding social support differences between urban and rural areas, it was found that relatives support is a positively significant factor for rural older adults, while friends support is significant for urban older adults.ConclusionsSince Internet use has many ways of impacting health status, social support only plays a partial mediating role in this study. It recommends that the government should take compelling measures to encourage and promote the use of the Internet among older adults and obtain various social support to improve their health status.
Analysis of the correlation between clinical nurses' professional quality of life and family care and organizational support
Authors: Xu Shan , Ju Dandan , Chen Ye , Wu Meiliyang , Wang Lan , Xi Xinxue , Zeng Tieying 
Published: February 2023

Background and aimNurses' professional quality of life (ProQOL) is closely related to nursing life, and it is essential to clarify the professional quality of life of nurses and enhance it effectively. We aimed to explore the influence of family care and organizational support on the professional quality of life of clinical nurses and to improve the theoretical basis for improving the professional quality of life of clinical nurses in China.MethodsA single center, descriptive, cross-sectional design was used in this study. From February to April 2,022, 2,200 nurses from Tongji Hospital were selected as the study population, using the General Information Form, Family Care Scale, Professional Quality of Life Scale, Nurses' Sense of Organizational Support Questionnaire, and Work-Family Conflict Scale, and analyzing the relationship between professional quality of life and family care and organizational support among clinical nurses for correlation analysis as well as multiple linear regression to determine the factors affecting participants' Factors affecting ProQOL. P &lt; 0.05 values were considered statistically significant.ResultsThe Cronbach coefficients of the scales were generally above 0.8, with good validity. All nurses had empathic satisfaction, burnout, and secondary trauma scores of 28.74 ± 3.83, 30.82 ± 3.45 and 29.40 ± 3.69, respectively, and correlation analysis, as well as multiple linear regression results, showed that the three dimensions of nurses' professional quality of life were associated with family care and organizational support (P &lt; 0.05).ConclusionsThe professional quality of life of nurses deserves to draw focused attention. The degree of family care and organizational support are predictive of professional quality of life, and nursing managers should pay attention to rationalizing tasks, pay attention to the physical and mental health of nursing staff, and improve the quality of life of nurses.
Efficacy of antiseptics and chemomechanical methods for dentin caries lesions: A systematic review with GRADE approach
Authors: Ferreira Luiza de Almeida Queiroz , Diniz Ivana Márcia Alves , Peixoto Rogéli Tibúrcio Ribeiro da Cunha , Gomes Natália Aparecida , Caneschi Camila de Sousa , Spineli Loukia Maria , Martins Carolina Castro 
Published: February 2023

ObjectivesSelective caries removal aims to remove carious tissue in deep dentin lesions. However, a discussion stands on the value of antiseptics and chemomechanical adjuvant methods to reduce the bacterial load on residual caries lesions. This systematic review has addressed two main clinical questions to compare the antimicrobial efficacy of available methods using (1) antiseptic or (2) chemomechanical agents before restoring dentin carious lesions.MethodsWe included randomized and non-randomized controlled trials (RCTs/ NRCTs). We searched eight databases from inception to October 2021. Paired reviewers independently screened studies, extracted data, and assessed the risk of bias. The primary outcome was the reduction in the number of total bacterial in dentin, whereas secondary outcomes were reduction in the number of Lactobacillus and Streptococcus. We used the ratio of ratio of post-treatment to baseline means between two interventions in the logarithmic scale as a proper effect measure. Certainty of evidence was assessed with the Grading of Recommendations, Assessment, Development and Evaluation approach.ResultsWe included 14 RCTs and 9 NRCTs, with nine interventions. Regardless the method, the number of bacteria at baseline was similar or exceeded that after the intervention, particularly in NRCTs. The evidence was inconclusive for most comparisons. Among antiseptic agents, chlorhexidine (CHX) resulted in an average of 1.14 times [95% confidence interval (CI): 1.08–1.21] more total bacterial than photodynamic therapy in RCTs. Among NRCTS, the natural agents resulted in five times more total bacterial than CHX (95% CI: 2–11). For chemomechanical methods, the control resulted in eight times (95% CI: 4–17) more total bacterial than Carisolv (SHAA).ConclusionsThe certainty of the evidence was very low for all comparisons showing uncertainty whether one treatment could be more effective than another for dentin disinfection. So far, exclusively removing soft carious dentin would be enough to reduce the bacterial count.
Gender role differentiation in household fuel transition decision-making: Implications for education and training in Uganda
Authors: Elasu Joseph , Ntayi Joseph Mpeera , Adaramola Muyiwa S. , Buyinza Faisal , Ngoma Muhammad , Atukunda Ronnette 
Published: February 2023

IntroductionThe role of gender and gender role differentiation has been of long standing interest and has remained a concern regarding the access and use of energy fuels for cooking in households. Although there seems to be a thin line between gender. However, studies on gender role differentiation in household fuel transition have framed gender as the biological construction of male and female rather than social roles.MethodsThis study used A multinomial probit regression model (MNP) to analyze the effect of gender role differentiation on household transition decisions from high to low-polluting fuels and their implications on education and training in Uganda. The study used the National Household Survey data collected by Uganda Bureau of Statistics.Findings and discussionThe findings revealed that the gender role differentiation significantly affected household fuel transition decisions. The study concludes by highlighting the implications of such gender role differentiation on education and training in Uganda.
How can the unnaturalness of cellular agricultural products be familiarized?: Modeling public attitudes toward cultured meats in Japan
Authors: Hibino Aiko , Nakamura Futoshi , Furuhashi Mai , Takeuchi Shoji 
Published: February 2023

IntroductionThis study aims to clarify how the unnaturalness of cellular agricultural products can be familiarized to society, using the case of the Japanese public's receptivity to cultured meats. Perceived unnaturalness is a key factor in the rejection of emerging technologies. While past studies have examined the explanatory factors involved in the public acceptance of cultured meats, the relationships among multiple factors have not been fully examined. Cultured meats and cellular agricultural products have been positively evaluated because they can contribute to future food sustainability, so the trade-off between perceived unnaturalness and sustainability is a significant issue for the public.MethodThis study uses a questionnaire survey with 2,000 Japanese respondents, which was conducted in 2019. Using a categorical data analysis approach, the strongest explanatory factors for receptivity were comprehensively searched among attitudes toward cultured meats, eating habits, demographics, and so on.Results and discussionThe results indicated that perceived unnaturalness showed a strong explanatory power for the rejection of cultured meats, but awareness of world famine problems increased acceptance of cultured meat, if the degree of the respondents' concern for unnaturalness was moderate. The perceived animacy of non-human life forms is also associated with acceptance of cultured meat, which may reflect Japanese cultural values. These results suggest multiple pathways to overcoming the disgust of new food technologies in the social implementation process.
Renormalization in Quantum Brain Dynamics
Authors: Nishiyama Akihiro , Tanaka Shigenori , Tuszynski Jack A. 
Published: February 2023

We show renormalization in Quantum Brain Dynamics (QBD) in 3+1 dimensions, namely Quantum Electrodynamics with water rotational dipole fields. First, we introduce the Lagrangian density for QBD involving terms of water rotational dipole fields, photon fields and their interactions. Next, we show Feynman diagrams with 1-loop self-energy and vertex function in dipole coupling expansion in QBD. The counter-terms are derived from the coupling expansion of the water dipole moment. Our approach will be applied to numerical simulations of Kadanoff–Baym equations for water dipoles and photons to describe the breakdown of the rotational symmetry of dipoles, namely memory formation processes. It will also be extended to the renormalization group method for QBD with running parameters in multi-scales.
Changements sociétaux et évolution de l'économie du fer du Hallstatt D à La Tène D dans le Nord-Est de la France
Authors: Berranger Marion , Bauvais Sylvain 
Published: February 2023

Les âges du Fer en Europe nord-occidentale voient la diffusion et l’adoption progressive du fer, puis une succession d’innovations majeures dans les techniques de sa production. Les procédés de fabrication d’objet se démocratisent, tandis que la consommation des objets s’intensifie et gagne l’ensemble des strates sociales. La maîtrise des productions métallurgiques est considérée de manière récurrente comme un des moteurs de l’émergence des centres de pouvoirs. Nous proposons d’analyser ce postulat à l’aune d’un bilan renouvelé de nos connaissances sur la métallurgie du fer en prenant en compte un large espace correspondant au Nord-Est de la France actuelle. Cela inclut les zones où se manifestent de manière ostentatoire les élites du premier et du début du second âge du Fer, puis l’armement et l’art
celtique florissant de La Tène moyenne. Pour la fin de l’âge du Fer, cet espace est également caractérisé par l’émergence de nouvelles formes de manifestations urbaines. À travers une grille de lecture structurée, composée de critères descriptifs issus de la littérature (Brun et al., 2006 ; Roux, 2000 ; Costin, 1991), nous proposons d’étudier les formes d’organisation des productions sidérurgiques et leur évolution au cours des âges du Fer. Il est ainsi possible de constater les trajectoires différentes suivies par les activités de réduction et de forgeage tout au long de cette période. Elles se développent durant le Hallstatt D – La Tène A sous
contrôle des élites. Cela mobilise, pour les activités de production de fer brut des savoir-faire simples, alors que les productions en forge documentent au contraire la maîtrise de techniques complexes évoquant un art de cours. À la fin des âges du Fer, les élites conservent leur emprise sur les moyens de production de centres de réduction fortement structurés, alors qu’à l’inverse, en forge, l’élargissement de la gamme des savoir-faire et la multiplicité des modes d’organisation permettent de reconnaître un artisanat maître de ses débouchés.