bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graphene-based zoom metalens adaptive imaging system
Authors: Zhang Qingyuan , Wang Xinyi , Liang Yawei , Chen Xiaogang , Shao Yan , Zhang Qiaozhen , Zhu Chenxi , Ma Shikai , Luo Yang 
Published: April 2023

Abstract
A definition adaptive imaging system based on graphene zoom metalens is proposed. It combines a tunable metalens and an image clarity detection algorithm. Compared with traditional imaging systems, the focus position of the metalens can be adjusted arbitrarily by changing the graphene chemical potential rather than the physical structure. Further, an edge detection algorithm is used to detect the image definition, and then judge whether the current focal length of the lens is appropriate. According to the predetermined strategy the system will automatically adjust the focus of the metalens until a satisfactory image is obtained.
Development of novel low-mass module concepts based on MALTA monolithic pixel sensors
Authors: Weick J. , Dachs F. , Riedler P. , Vicente Barreto Pinto M. , Zoubir A.M. , Flores Sanz de Acedo L. , Asensi Tortajada I. , Dao V. , Dobrijevic D. , Pernegger H. , Van Rijnbach M. , Sharma A. , Solans Sanchez C. , de Oliveira R. , Dannheim D. , Schmidt J.V. 
Published: April 2023

Abstract
The MALTA CMOS monolithic silicon pixel sensors has been developed in the Tower 180 nm CMOS imaging process. It includes an asynchronous readout scheme and complies with the ATLAS inner tracker requirements for the HL-LHC. Several 4-chip MALTA modules have been built using Al wedge wire bonding to demonstrate the direct transfer of data from chip-to-chip and to read out the data of the entire module via one chip only. Novel technologies such as Anisotropic Conductive Films (ACF) and nanowires have been investigated to build a compact module. A lightweight flex with 17 μm trace spacing has been designed, allowing compact packaging with a direct attachment of the chip connection pads to the flex using these interconnection technologies. This contribution shows the current state of our work towards a flexible, low material, dense and reliable packaging and modularization of pixel detectors.
Special issue: bioinspired fluid-structure interaction
Authors: Jung Sunghwan , Godoy-Diana Ramiro 
Published: April 2023

Abstract
Fluid-structure interaction (FSI) studies the interaction between fluid and solid objects. It helps understand how fluid motion affects solid objects and vice versa. FSI research is important in engineering applications such as aerodynamics, hydrodynamics, and structural analysis. It has been used to design efficient systems such as ships, aircraft, and buildings. FSI in biological systems has gained interest in recent years for understanding how organisms interact with their fluidic environment. Our special issue features papers on various biological and bio-inspired FSI problems. Papers in this special issue cover topics ranging from flow physics to optimization and diagonistics. These papers offer new insights into natural systems and inspire the development of new technologies based on natural principles.
Humans predict the forest, not the trees: statistical learning of spatiotemporal structure in visual scenes
Authors: Yan Chuyao , Ehinger Benedikt V , Pérez-Bellido Alexis , Peelen Marius V , de Lange Floris P 
Published: April 2023

Abstract
The human brain is capable of using statistical regularities to predict future inputs. In the real world, such inputs typically comprise a collection of objects (e.g. a forest constitutes numerous trees). The present study aimed to investigate whether perceptual anticipation relies on lower-level or higher-level information. Specifically, we examined whether the human brain anticipates each object in a scene individually or anticipates the scene as a whole. To explore this issue, we first trained participants to associate co-occurring objects within fixed spatial arrangements. Meanwhile, participants implicitly learned temporal regularities between these displays. We then tested how spatial and temporal violations of the structure modulated behavior and neural activity in the visual system using fMRI. We found that participants only showed a behavioral advantage of temporal regularities when the displays conformed to their previously learned spatial structure, demonstrating that humans form configuration-specific temporal expectations instead of predicting individual objects. Similarly, we found suppression of neural responses for temporally expected compared with temporally unexpected objects in lateral occipital cortex only when the objects were embedded within expected configurations. Overall, our findings indicate that humans form expectations about object configurations, demonstrating the prioritization of higher-level over lower-level information in temporal expectation.
Dynamics of corticocortical brain functional connectivity relevant to therapeutic response to biologics in inflammatory arthritis
Authors: Sakiyama Kodai , Abe Nobuya , Fujieda Yuichiro , Tha Khin K , Narita Hisashi , Karino Kohei , Kanda Masatoshi , Kono Michihito , Kato Masaru , Atsumi Tatsuya 
Published: April 2023

Abstract
Aberrant functional connectivity (FC) of the brain regions, evaluated by functional magnetic resonance imaging (fMRI), affects clinical courses in inflammatory arthritis (IA). The static analysis methods would be simplistic to estimate the whole picture of resting-state brain function because blood oxygen level-dependent (BOLD) signals fluctuate over time. The effects of FC dynamics on clinical course are unknown in IA. Therefore, we aimed to evaluate dynamic FC for therapeutic responsiveness to biologics in IA patients. We analyzed resting-state fMRI data of 64 IA patients in 2 cohorts. Dynamic FC was derived as a correlation coefficient of the windowed BOLD signal time series. We determined representative whole-brain dynamic FC patterns by k-means++ cluster analysis, leading to 4 distinct clusters. In the first cohort, occurrence probability of the distinct cluster was associated with favorable therapeutic response in disease activity and patients’ global assessment, which was validated by the second cohort. The whole-brain FC of the distinct cluster indicated significantly increased corticocortical connectivity, and probabilistically decreased after therapy in treatment-effective patients compared with -ineffective patients. Taken together, frequent emergence of corticocortical connections was associated with clinical outcomes in IA. The coherence of corticocortical interactions might affect pain modulation, possibly relevant to therapeutic satisfaction.
Increases in group A streptococcal infections in the pediatric population in Houston, TX, 2022
Authors: Aboulhosn Aya , Sanson Misu A , Vega Luis Alberto , Segura Maria G , Summer Lauren M , Joseph Marritta , McNeil J Chase , Flores Anthony R 
Published: April 2023

Abstract
Beginning in October 2022, we observed a substantial increase in the total number of cases of invasive GAS disease (iGAS) in the pediatric population in Houston, TX. Emm12 GAS strains were disproportionately represented but the overall proportion of iGAS infections observed during the current spike was similar to pre-pandemic years.
Interleukin 6 Blockade With Tocilizumab Diminishes Indices of Inflammation That Are Linked to Mortality in Treated Human Immunodeficiency Virus Infection
Authors: Funderburg Nicholas T , Shive Carey L , Chen Zhengyi , Tatsuoka Curtis , Bowman Emily R , Longenecker Chris T , McComsey Grace A , Clagett Brian M , Dorazio Dominic , Freeman Michael L , Sieg Scott F , Moisi Daniela , Anthony Donald D , Jacobson Jeffrey M , Stein Sharon L , Calabrese Leonard H , Landay Alan , Flexner Charles , Crawford Keith W , Capparelli Edmund V , Rodriguez Benigno , Lederman Michael M 
Published: April 2023

Abstract

Background
People with human immunodeficiency virus (PWH) are at increased risk for comorbidities, and plasma interleukin 6 (IL-6) levels are among the most robust predictors of these outcomes. Tocilizumab (TCZ) blocks the receptor for IL-6, inhibiting functions of this cytokine.

Methods
This was a 40-week, placebo-controlled, crossover trial (NCT02049437) where PWH on stable antiretroviral therapy (ART) were randomized to receive 3 monthly doses of TCZ or matching placebo intravenously. Following a 10-week treatment period and a 12-week washout, participants were switched to the opposite treatment. The primary endpoints were safety and posttreatment levels of C-reactive protein (CRP) and CD4+ T-cell cycling. Secondary endpoints included changes in inflammatory indices and lipid levels.

Results
There were 9 treatment-related toxicities of grade 2 or greater during TCZ administration (mostly neutropenia) and 2 during placebo administration. Thirty-one of 34 participants completed the study and were included in a modified intent-to-treat analysis. TCZ reduced levels of CRP (median decrease, 1819.9 ng/mL, P &lt; .0001; effect size, 0.87) and reduced inflammatory markers in PWH, including D-dimer, soluble CD14, and tumor necrosis factor receptors. T-cell cycling tended to decrease in all maturation subsets after TCZ administration, but was only significant among naive CD4 T cells. Lipid levels, including lipid classes that have been related to cardiovascular disease risk, increased during TCZ treatment.

Conclusions
TCZ is safe and decreases inflammation in PWH; IL-6 is a key driver of the inflammatory environment that predicts morbidity and mortality in ART-treated PWH. The clinical significance of lipid elevations during TCZ treatment requires further study.
Clinical Trials Registration. NCT02049437.
Pathogenic SCN2A variants cause early-stage dysfunction in patient-derived neurons
Authors: Asadollahi R , Delvendahl I , Muff R , Tan G , Rodríguez D G , Turan S , Russo M , Oneda B , Joset P , Boonsawat P , Masood R , Mocera M , Ivanovski I , Baumer A , Bachmann-Gagescu R , Schlapbach R , Rehrauer H , Steindl K , Begemann A , Reis A , Winkler J , Winner B , Müller M , Rauch A 
Published: April 2023

Abstract
Pathogenic heterozygous variants in SCN2A, which encodes the neuronal sodium channel NaV1.2, cause different types of epilepsy or intellectual disability (ID)/autism without seizures. Previous studies using mouse models or heterologous systems suggest that NaV1.2 channel gain-of-function typically causes epilepsy, whereas loss-of-function leads to ID/autism. How altered channel biophysics translate into patient neurons remains unknown. Here, we investigated iPSC-derived early-stage cortical neurons from ID patients harboring diverse pathogenic SCN2A variants [p.(Leu611Valfs*35); p.(Arg937Cys); p.(Trp1716*)] and compared them with neurons from an epileptic encephalopathy (EE) patient [p.(Glu1803Gly)] and controls. ID neurons consistently expressed lower NaV1.2 protein levels. In neurons with the frameshift variant, NaV1.2 mRNA and protein levels were reduced by ~ 50%, suggesting nonsense-mediated decay and haploinsufficiency. In other ID neurons, only protein levels were reduced implying NaV1.2 instability. Electrophysiological analysis revealed decreased sodium current density and impaired action potential (AP) firing in ID neurons, consistent with reduced NaV1.2 levels. In contrast, epilepsy neurons displayed no change in NaV1.2 levels or sodium current density, but impaired sodium channel inactivation. Single-cell transcriptomics identified dysregulation of distinct molecular pathways including inhibition of oxidative phosphorylation in neurons with SCN2A haploinsufficiency and activation of calcium signaling and neurotransmission in epilepsy neurons. Together, our patient iPSC-derived neurons reveal characteristic sodium channel dysfunction consistent with biophysical changes previously observed in heterologous systems. Additionally, our model links the channel dysfunction in ID to reduced NaV1.2 levels and uncovers impaired AP firing in early-stage neurons. The altered molecular pathways may reflect a homeostatic response to NaV1.2 dysfunction and can guide further investigations.
Real-World Effectiveness of Primary Series and Booster Doses of Inactivated Coronavirus Disease 2019 Vaccine Against Omicron BA.2 Variant Infection in China: A Retrospective Cohort Study
Authors: Tang Lin , Wang Fu-Zhen , Rodewald Lance E , Wang Xuan-Yi , Liu Si-Yu , Liu Qian-Qian , Wang Xiao-Qi , Wu Dan , Li Ming-Shuang , Zhang Qian , Shao Yi-Ming , Huang Li-Fang , Song Yu-Dan , Huang Yong , Zeng Xiang , Liu Li-Jun , Yang Hong , Huang Ao-Di , Bao Li-Ming , Zheng Hui , Ma Chao , Lv Xiao-Ya , Song Lei , Ma Zhao , Wang Shu-Guang , Ma Hao , Guan Wei-Jie , Wu Zhi-Yin , Zhong Nan-Shan , Yin Zun-Dong 
Published: April 2023

Abstract

Background
China has been using inactivated coronavirus disease 2019 (COVID-19) vaccines as primary series and booster doses to protect the population from severe to fatal COVID-19. We evaluated primary and booster vaccine effectiveness (VE) against Omicron BA.2 infection outcomes.

Methods
This was a 13-province retrospective cohort study of quarantined close contacts of BA.2-infected individuals. Outcomes were BA.2 infection, COVID-19 pneumonia or worse, and severe/critical COVID-19. Absolute VE was estimated by comparison with an unvaccinated group.

Results
There were 289 427 close contacts ≥3 years old exposed to Omicron BA.2 cases; 31 831 turned nucleic acid amplification test–positive during quarantine, 97.2% with mild or asymptomatic infection, 2.6% with COVID-19 pneumonia, and 0.15% with severe/critical COVID-19. None died. Adjusted VE (aVE) against any infection was 17% for primary series and 22% when boosted. Primary series aVE in adults &gt;18 years was 66% against COVID-19 pneumonia or worse and 91% against severe/critical COVID-19. Booster dose aVE was 74% against pneumonia or worse, and 93% against severe/critical COVID-19.

Conclusions
Inactivated COVID-19 vaccines provided modest protection from infection, very good protection against pneumonia, and excellent protection against severe/critical COVID-19. Booster doses are necessary to provide strongest protection.
A marker-based neural network system for extracting social determinants of health
Authors: Zhao Xingmeng , Rios Anthony 
Published: April 2023

Abstract

Objective
The impact of social determinants of health (SDoH) on patients’ healthcare quality and the disparity is well known. Many SDoH items are not coded in structured forms in electronic health records. These items are often captured in free-text clinical notes, but there are limited methods for automatically extracting them. We explore a multi-stage pipeline involving named entity recognition (NER), relation classification (RC), and text classification methods to automatically extract SDoH information from clinical notes.

Materials and Methods
The study uses the N2C2 Shared Task data, which were collected from 2 sources of clinical notes: MIMIC-III and University of Washington Harborview Medical Centers. It contains 4480 social history sections with full annotation for 12 SDoHs. In order to handle the issue of overlapping entities, we developed a novel marker-based NER model. We used it in a multi-stage pipeline to extract SDoH information from clinical notes.

Results
Our marker-based system outperformed the state-of-the-art span-based models at handling overlapping entities based on the overall Micro-F1 score performance. It also achieved state-of-the-art performance compared with the shared task methods. Our approach achieved an F1 of 0.9101, 0.8053, and 0.9025 for Subtasks A, B, and C, respectively.

Conclusions
The major finding of this study is that the multi-stage pipeline effectively extracts SDoH information from clinical notes. This approach can improve the understanding and tracking of SDoHs in clinical settings. However, error propagation may be an issue and further research is needed to improve the extraction of entities with complex semantic meanings and low-frequency entities. We have made the source code available at https://github.com/Zephyr1022/SDOH-N2C2-UTSA.
The evaluation of the supplementation of vitamin A, beta-carotene, and oxidized beta-carotene in prepubertal gilts
Authors: Elefson Sarah K , Greiner Laura L 
Published: April 2023

AbstractFinishing pigs (N = 224; 28.66 ± 1.90 kg bodyweight) were randomly assigned across 56 pens of either four barrows or gilts, and assigned to one of four diets: control (7,656 IU vitamin A/kg), control supplemented with vitamin A (4.36 ppm, Rovimix A 1000, DSM, Parsippany, NJ, USA), control supplemented with beta-carotene (163.28 ppm, Rovimix β-Carotene 10%, DSM, Parsippany), or control supplemented with oxidized beta-carotene (40 ppm; 10% active ingredient, Avivagen, Ottawa, ON, Canada). Pigs and feeder weights were obtained at the start of the study (d 0), and end of each phase (d 21, 42, and 63). A subset of gilts had a blood sample taken via jugular venipuncture on d 0, a blood sample and vaccinations of Lawsonia intracellularis and porcine circovirus type 2 (PCV2) on d 18, a blood sample and booster vaccination of PCV2 on d 39, a blood sample on day 60, and a final blood sample on day 63. Gilts were euthanized at the end of the study to obtain a liver (entire right lobe) and a jejunum sample (15.24 cm at 10% of length). Additionally, the second and fourth right anterior mammary were collected to assess anterior mammary tissues. Data were analyzed in SAS 9.4 (Statistical Analysis System, Cary, NC) via GLIMMIX procedure. Oxidized beta-carotene supplementation increased (P = 0.02) ADG across phases over vitamin A supplementation, although there were no differences (P = 0.18) in the body weight of pigs. There was no effect (P &gt; 0.05) of diet on plasma or hepatic retinol, IgG or IgM levels, or immune cell presence in developing mammary tissue. Supplemented vitamin A tended (P = 0.05) to increase the mRNA abundance of retinol binding protein in the jejunum, but other mRNA abundance for genes (alcohol dehydrogenase class 1, lecithin retinol acyltransferase phosphatidylcholine-retinol O-acyltransferase, and beta-carotene oxygenase 1) were not affected (P &gt; 0.05) by dietary treatments. A diet by time interaction (P = 0.04) was noted for the circovirus S/P ratio, where vitamin A supplementation had the best ratio compared to other diets. Analyzed titer levels for the circovirus vaccine had an interaction (P &lt; 0.01) for diet by time, where vitamin A supplementation had the highest titer at the end of the study. Thus, pigs supplemented with oxidized beta-carotene had an improved ADG over vitamin A supplemented pigs, but pigs supplemented with vitamin A seemed to have an improved immune status.
Resilience as a predictor for why some marital relationships flourished and others struggled during the initial months of COVID-19
Authors: Salehuddin Abdullah S , King Jesse , Afifi Tamara D , Afifi Walid A 
Published: April 2023

Abstract
Using the theory of resilience and relational load, this study examined how married individuals’ baseline communal orientation (CO) and relational load (RL) at the beginning of the pandemic predicted their stress, conflict, mental health, and flourishing during quarantine. Using a Qualtrics Panel, married individuals (N = 3,601) completed four online surveys from April to June 2020. Results revealed the initial levels of CO brought to quarantine predicted less stress and conflict, and better mental health and flourishing at baseline, and these outcomes remained relatively stable across the next 3 months. RL at baseline did the exact opposite for these outcomes, making coping more difficult. We also hypothesized CO and RL moderate the impact of stress (T1) on mental health 3 months later by reducing conflict. Rather than serving as buffers, CO and RL at baseline directly affected conflict (T2/T3) and mental health (T4) throughout quarantine.
Testing homogeneity: the trouble with sparse functional data
Authors: Zhu Changbo , Wang Jane-Ling 
Published: April 2023

Abstract
Testing the homogeneity between two samples of functional data is an important task. While this is feasible for intensely measured functional data, we explain why it is challenging for sparsely measured functional data and show what can be done for such data. In particular, we show that testing the marginal homogeneity based on point-wise distributions is feasible under some mild constraints and propose a new two-sample statistic that works well with both intensively and sparsely measured functional data. The proposed test statistic is formulated upon energy distance, and the convergence rate of the test statistic to its population version is derived along with the consistency of the associated permutation test. The aptness of our method is demonstrated on both synthetic and real data sets.
Multi-copper oxidases SKU5 and SKS1 coordinate cell wall formation using apoplastic redox-based reactions in roots
Authors: Chen Chaofan , Zhang Yi , Cai Jianfa , Qiu Yuting , Li Lihong , Gao Chengxu , Gao Yiqun , Ke Meiyu , Wu Shengwei , Wei Chuan , Chen Jiaomei , Xu Tongda , Friml Jiří , Wang Junqi , Li Ruixi , Chao Daiyin , Zhang Baocai , Chen Xu , Gao Zhen 
Published: April 2023

Abstract
The primary cell wall is a fundamental plant constituent that is flexible but sufficiently rigid to support the plant cell shape. Although many studies have demonstrated that reactive oxygen species (ROS) serve as important signaling messengers to modify the cell wall structure and affect cellular growth, the regulatory mechanism underlying the spatial-temporal regulation of ROS activity for cell wall maintenance remains largely unclear. Here, we demonstrate the role of the Arabidopsis (Arabidopsis thaliana) multicopper oxidase-like protein skewed 5 (SKU5) and its homolog SKU5-similar 1 (SKS1) in root cell wall formation through modulating ROS homeostasis. Loss of SKU5 and SKS1 function resulted in aberrant division planes, protruding cell walls, ectopic deposition of iron, and reduced nicotinamide adeninedinucleotide phosphate (NADPH) oxidase-dependent ROS overproduction in the root epidermis–cortex and cortex–endodermis junctions. A decrease in ROS level or inhibition of NADPH oxidase activity rescued the cell wall defects of sku5 sks1 double mutants. SKU5 and SKS1 proteins were activated by iron treatment, and iron over-accumulated in the walls between the root epidermis and cortex cell layers of sku5 sks1. The glycosylphosphatidylinositol-anchored motif was crucial for membrane association and functionality of SKU5 and SKS1. Overall, our results identified SKU5 and SKS1 as regulators of ROS at the cell surface for regulation of cell wall structure and root cell growth.