bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of subcutaneous fat area and Systemic Immune-inflammation Index with survival in patients with advanced gastric cancer receiving dual PD-1 and HER2 blockade
Authors: He Meng , Chen Zi-Fan , Zhang Li , Gao Xiangyu , Chong Xiaoyi , Li Hao-shen , Shen Lin , Ji Jiafu , Zhang Xiaotian , Dong Bin , Li Zi-Yu , Lei Tang 
Published: June 2023

BackgroundSystemic Immune-inflammation Index (SII) and body composition parameters are easily assessed, and can predict overall survival (OS) in various cancers, allowing early intervention. This study aimed to assess the correlation between CT-derived body composition parameters and SII and OS in patients with advanced gastric cancer receiving dual programmed death-1 (PD-1) and human epidermal growth factor receptor 2 (HER2) blockade.Materials and methodsThis retrospective study enrolled patients with advanced gastric cancer treated with dual PD-1 and HER2 blockade from March 2019 to June 2022. We developed a deep learning model based on nnU-Net to automatically segment skeletal muscle, subcutaneous fat and visceral fat at the third lumbar level, and calculated the corresponding Skeletal Muscle Index, skeletal muscle density, subcutaneous fat area (SFA) and visceral fat area. SII was computed using the formula that total peripheral platelet count×neutrophil/lymphocyte ratio. Univariate and multivariate Cox regression analysis were used to determine the associations between SII, body composition parameters and OS.ResultsThe automatic segmentation deep learning model was developed to efficiently segment body composition in 158 patients (0.23 s/image). Multivariate Cox analysis revealed that high SII (HR=2.49 (95% CI 1.54 to 4.01), p<0.001) and high SFA (HR=0.42 (95% CI 0.24 to 0.73), p=0.002) were independently associated with OS, whereas sarcopenia was not an independent prognostic factor for OS (HR=1.41 (95% CI 0.86 to 2.31), p=0.173). In further analysis, patients with high SII and low SFA had worse long-term prognosis compared with those with low SII and high SFA (HR=8.19 (95% CI 3.91 to 17.16), p<0.001).ConclusionPretreatment SFA and SII were significantly associated with OS in patients with advanced gastric cancer. A comprehensive analysis of SII and SFA may improve the prognostic stratification of patients with gastric cancer receiving dual PD-1 and HER2 blockade.
Concurrent immune checkpoint inhibition and selective immunosuppressive therapy in patients with immune-related enterocolitis
Authors: Badran Yousef R , Zou Fangwen , Durbin Sienna M , Dutra Barbara E , Abu-Sbeih Hamzah , Thomas Anusha S , Altan Mehmet , Thompson John A , Qiao Wei , Leet Donna E , Lai Po-Ying , Horick Nora K , Postow Michael A , Faleck David M , Wang Yinghong , Dougan Michael 
Published: June 2023

PurposeImmune checkpoint inhibitor (ICI) therapy is often suspended because of immune-related enterocolitis (irEC). We examined the effect of resumption of ICIs with or without concurrent selective immunosuppressive therapy (SIT) on rates of symptom recurrence and survival outcomes.MethodsThis retrospective, multicenter study examined patients who were treated with ICI and developed irEC requiring SIT (infliximab or vedolizumab) for initial symptom control or to facilitate steroid tapering between May 2015 and June 2020. After symptom resolution, patients were restarted either on ICI alone or on concurrent ICI and SIT at the discretion of the treating physicians. The associations between irEC recurrence and treatment group were assessed via univariate analyses and multivariate logistic regression. Cox proportional hazards model was used for survival analysis.ResultsOf the 138 included patients who required SIT for initial irEC symptom control, 61 (44.2%) patients resumed ICI without concurrent SIT (control group) and 77 (55.8%) patients resumed ICI therapy with concurrent SIT: 33 with infliximab and 44 with vedolizumab. After symptom resolution, patients in the control group were more commonly restarted on a different ICI regimen (65.6%) compared with those receiving SIT (31.2%) (p<0.001). The total number of ICI doses administered after irEC resolution and ICI resumption was similar in both groups (four to five doses). Recurrence of severe colitis or diarrhea after ICI resumption was seen in 34.4% of controls compared with 20.8% of patients receiving concurrent SIT. Concurrent SIT was associated with reduced risk of severe irEC recurrence after ICI resumption in a multivariate logistic regression model (OR 0.34; 95% CI 0.13 to 0.92; p=0.034). There was no difference in survival outcomes between patients in the control group and patients concurrently treated with SIT.ConclusionAfter resolution of irEC symptoms, reinitiation of ICI with concurrent SIT is safe, reduces severe irEC recurrence, and has no negative impact on survival outcomes.
Drugless and radiographer led: the start of a new era for CT coronary angiography
Authors: Morgan-Hughes Gareth , McNally Rebecca , Gibbs Christopher Gibbs , Iacovides Stelios , Kirat-Rai Prabesh , Thiriphoo Nang , Powell Alison , Stuckey Colin , Thorpe Ross , Mayo Louisa , Roobottom Carl 
Published: June 2023

ObjectiveSince inception CT coronary angiography (CTCA) has required facilitating beta blockers (BB). However, CT technology has improved rapidly as has radiographer and reporter expertise. Using these factors, we instituted a radiographer led cardiac CT service (RLCCTS), without routine BB, which we studied for quality control (QC).MethodsRLCCTS started October 2021 using a wide detector array CT system, with 20 min slots. QC study was registered with the clinical audit team, University Hospitals Plymouth, CA_2020-21-118. Uniform reporting was agreed including indication, BB administration, demographics, dose length product (DLP) and the coronary artery disease—reporting and data system (CAD-RADS) score. Uncertain CAD-RADS meant a non-diagnostic scan (NDS). Six months of data were collected; stable chest pain (SCP) patients, who have national CTCA QC comparators, were analysed using descriptive statistics.ResultsOf 1475 patients, 447 were not SCP patients—known CAD (157); valves (286); removed (4, data incomplete) leaving 1028 SCP patients CTCA for analysis. Demographics—mean age 63 years, body mass index 29, 50.4% women. BB therapy—four patients (two recalls). Overall, 36/1024 or 3.5% were NDS; median DLP 173mGy×cm; mean heart rate (HR) 70 bpm, 99/1024 or 9.7% HR >90 bpm (45% not sinus rhythm).ConclusionsQuality for RLCCTS was judged by NDS rate and DLP. National QC comparators suggest 4% NDS rate; median DLP for SCPP CTCA 209 mGy×cm. RLCCTS compares favourably. With modern cardiac CT, experienced radiographers and reporters, ‘drugless’ RLCCTS can deliver 20 min slot CTCA with satisfactory QC indicators.
Changes in body weight and body composition in patients with active rheumatoid arthritis aged 65+ treated with 2-year low-dose add-on prednisolone in the randomised double-blind placebo-controlled GLORIA trial
Authors: Güler-Yüksel Melek , Kuijper Martijn , Bos Reinhard , Molenaar Esmeralda , Emmering Jasper , Eshuis Sylvia , Human Adams , Reimann Floor , Boers Maarten , Kok Marc R 
Published: June 2023

ObjectivesTo investigate the effect of 2 years of add-on prednisolone 5 mg/day on body weight and composition in patients with active rheumatoid arthritis (RA) aged 65+ and the relation with disease activity.MethodsThe Glucocorticoid Low-dose Outcome in RheumatoId Arthritis trial, a pragmatic, placebo-controlled, double-blind, randomised controlled trial investigated the balance of benefit and harm of 2 years of prednisolone 5 mg/day added to standard care in 451 patients with active RA aged 65+. In the current study, 449 patients were included, and body weight and Disease Activity Score of 28 Joints were measured at baseline and after 3, 6, 12, 18 and 24 months. In 57 patients, body composition was assessed at baseline and after 2 years with dual-energy X-ray absorptiometry. Data were analysed with longitudinal mixed models.ResultsThe mean (95% CI) change in body weight was 0.9 (0.3 to 1.6) kg in the prednisolone group and –0.4 (–1.1 to 0.2) kg in the placebo group (difference 1.3 (0.5–2.2), (p<0.01)). The treatment effect was independent of disease activity suppression and comprised mostly increase in (appendicular) lean mass after 2 years. There was no significant increase in total fat mass, nor redistribution of fat mass from peripheral to central tissues.ConclusionsPatients with active RA aged 65+ treated with prednisolone 5 mg/day for 2 years gained about 1 kg in weight, compared with minimal—non-significant—weight loss on placebo. Our data suggest that the small increase in weight is mostly lean mass, rather than increase or redistribution of fat mass traditionally associated with glucocorticoid treatment.
Characterisation of prodromal and very early psoriatic arthritis: a systematic literature review informing a EULAR taskforce
Authors: De Marco Gabriele , Zabotti Alen , Baraliakos Xenofon , Iagnocco Annamaria , Aletaha Daniel , Gisondi Paulo , Emmel Jenny , Smolen Josef S , McGonagle Dennis G , Gossec Laure 
Published: June 2023

BackgroundIdentifying subjects at risk of imminent psoriatic arthritis (PsA) would allow these subjects to participate in therapeutic interventions to delay or prevent PsA development.MethodsA systematic literature review (SLR) was conducted in 2021 in Medline, Embase, PubMed, Central databases and international congress abstracts (PROSPERO CRD42022255102). All articles reporting the characteristics of patients transitioning from psoriasis (PsO) to PsA and from undifferentiated arthritis (UA) to PsA were included. Clinical and imaging characteristics were collated before PsA onset and at time of PsA diagnosis.ResultsEighteen of 23 576 references evaluated for PsO/PsA transition were analysed; 14 were cohort studies, 2 case-control studies. Two SLRs were used to enrich the project but were not analysed per se. Of 7873 references focusing on UA to PsA, 3 studies were included. Meta-analysis was not possible due to excessive data heterogeneity. Patients with PsO who developed PsA often reported joint pain, joint tenderness and functional limitations. Arthralgia (PsO, n=669; incident PsA, n=99) was associated with subsequent PsA development. On imaging, subclinical enthesopathy (PsO=325; Incident PsA=39) appeared linked to later PsA development. At the time of PsA onset (incident PsA, N=214), peripheral arthritis, mainly oligo-arthritis (ie, the mean number of swollen joints ranged from 1.5 to 3.2), was the most frequent pattern of clinical presentation.ConclusionsJoint pain, arthralgia and entheseal involvement detected by imaging were frequent in individuals with PsO at risk for imminent PsA. Very early PsA was mainly oligoarticular. This review informed a EULAR taskforce on transition to PsA.
Measuring treatment outcomes and change in disease activity in giant cell arteritis: a systematic literature review informing the development of the EULAR-ACR response criteria on behalf of the EULAR-ACR response criteria in giant cell arteritis task force
Authors: Sanchez-Alvarez Catalina , Bond Milena , Soowamber Medha , Camellino Dario , Anderson Melanie , Langford Carol A , Dejaco Christian , Touma Zahi , Ramiro Sofia 
Published: June 2023

ObjectivesTo identify criteria and descriptors used to measure response to treatment and change in disease activity in giant cell arteritis (GCA).MethodsA systematic literature review (SLR) to retrieve randomised controlled trials (RCTs) and longitudinal observational studies (LOS). Criteria and descriptors of active disease, remission, response, improvement, worsening and relapse were extracted. RCTs, LOS with >20 subjects, and qualitative research studies were included.Results10 593 studies were retrieved, of which 116 were included (11 RCTs, 104 LOS, 1 qualitative study). No unified definition of response to therapy was found. Most RCTs used composite endpoints to assess treatment outcomes. Active disease was described in all RCTs and 19% of LOS; and was largely defined by a combination of clinical and laboratory components. Remission was reported in 73% of RCTs and 42% of LOS; It was predominantly defined as the combination of clinical and laboratory components. One LOS reported response with a definition resembling the definition of remission from other studies. Improvement was rarely used as an endpoint and it was mostly a surrogate of remission. No study specifically defined worsening. Relapse was reported in all RCTs and 86% of LOS. It was predominantly defined as the combination of clinical, laboratory and treatment components.ConclusionsThe results of this SLR demonstrate that definitions of response used in clinical studies of GCA are scant and heterogeneous. RCTs and LOS mainly used remission and relapse as treatment outcomes. The descriptors identified will inform the development of the future European Alliance of Associations for Rheumatology-American College of Rheumatology response criteria for GCA.
Does the climate influence the variance of residual in litter traits of Taiwan Landrace sows?
Authors: Lin Kai-Hsiang , Wu Ruei-Syuan , Lin En-Chung 
Published: June 2023

Heat stress adversely affects the litter traits of Landrace, the primary dam breed in Taiwan. This study aimed to evaluate the effects of heat stress during sow pregnancy with homogeneous and heterogeneous residuals to estimate the genetic parameters of the Taiwan Landrace. Performance records for 11 657 litters and weather data from 2008 to 2021 were collected. The climate effect was defined proportionally from cool to hot for climates 1 to 5. The homogeneous residual analysis showed that the heritabilities of the total number born (TNB) and number born alive (NBA) were 0.164 ± 0.014 and 0.111 ± 0.014 with residual variances of 10.338 and 9.164, respectively. The heterogeneous residual analysis showed that the residual variances for TNB and NBA were 8.934–11.113 and 8.196–9.810, respectively. For TNB, the residual variance in the herd–year–climate effect differed significantly in climate 1 from climates 3 to 5 ( p < 0.01). In NBA, the residual variance was significantly lower in climates 1 and 2 than in climates 3 and 5 ( p < 0.01). In conclusion, heritability was estimated for TNB and NBA. In addition, residual variances could interact with the climate effect in heterogeneous residual analysis.
Structural transformations and non-equilibrium phenomena in multicomponent disordered systems
Authors: Toropova Liubov V. , Nizovtseva Irina G. 
Published: June 2023

AbstractThe issue is devoted to theoretical, computational, and experimental studies of phase and structural transitions and non-equilibrium phenomena (phase transformations, heat generation, rheology, and relaxation phenomena) in disordered systems, e.g., composite and metastable materials, biological tissues and systems; polymer and other soft materials; amorphous and glass-forming systems, as well as multicomponent melts. Special attention is paid to the detailed microscopical study of various phenomena in the aforementioned systems.
Universal magnetoresistance of a quasi-two-dimensional conductor in perpendicular electric and parallel magnetic fields
Authors: Lebed Andrei G. 
Published: June 2023

Some times ago, in the framework of the Boltzmann kinetic equation in the so-called [Formula: see text]-approximation, it was shown that perpendicular resistivity in quasi-two-dimensional (Q2D) conductors can be impurity independent in a broad range of high parallel magnetic fields [A. G. Lebed and N. N. Bagmet, Phys. Rev. B 55 (1997) R8654]. In this paper, we demonstrate that this result is much more general than the Boltzmann kinetic equation in the [Formula: see text]-approximation and is valid in a pure Q2D metal at low frequencies of the electric field. The above-mentioned statement open possibilities to test the above discussed phenomenon in a number of Q2D organic, high-Tc, and some other Q2D superconductors in their metallic phases and gives a method to extract some important information about their Q2D Fermi surfaces.
Towards Exogenous Coordination of Concurrent Cloud Applications
Authors: Le-Khanh Trinh , Nguyen Hoang-Gia , Bliudze Simon , Merle Philippe 
Published: June 2023

Cloud computing offers opportunities to increase productivity and reduce costs. Quickly adapting to changing needs is key to maintaining cloud applications. In traditional development, coordination is implemented in computational code. Although change impact analyses are studied, adjusting the implementation is time-consuming and error-prone when the coordination strategy changes. Exogenous coordination separates the implemented coordination and computational code to cope with this problem. This separation improves the reusability of components. Additionally, other applications with similar interaction patterns can reuse the coordination specification. The main contribution of this paper is to propose a methodology to develop and maintain cloud applications following the exogenous approach. To illustrate the idea, we introduce a new framework named OCCIwareBIP, which integrates JavaBIP — a framework for the exogenous coordination of concurrent Java components into OCCIware — a framework for designing cloud applications. We also leverage the coordination model to verify the deadlock-freedom of the cloud application. Finally, we present an application to show the ability of our approach to guarantee the safety and benefits of modularization in developing concurrent cloud applications.
WEAR, CORROSION AND HARDNESS ANALYSIS OF WC10Co4Cr AND WC10Co4Cr+GNPs COATING ON ASTM-A479 STEEL
Authors: KUMAR VIJAY , VERMA RAJEEV 
Published: June 2023

In this study, WC10Co4Cr (particle size [Formula: see text][Formula: see text][Formula: see text]m) and WC10Co4Cr+Graphen nano-platelets (GNPs) of particle size [Formula: see text][Formula: see text][Formula: see text]m cermet coatings were deposited on an ASTM A479 steel substrate utilising the High-Velocity Oxygen Fuel (HVOF) technique. The wear and corrosion of coated and uncoated surfaces were studied using the pin-on-disc and salt spray testing methods, respectively, and the micro-hardness of the cross-sections was tested using a Vickers micro-hardness testing machine at an applied force of 10[Formula: see text]N. Further, surface morphology of coated and uncoated substrate was investigated using scanning electron microscopy (SEM) and microscopic images. The analysis revealed that WC-10Co-[Formula: see text]-coated (C2) surfaces outperformed WC10Co4Cr coated (C1) surfaces in terms of wear resistance.
Isotopic and geochemical characteristics of mid- to-late-Miocene continental and oceanic arc volcanic and intrusive rocks, central North Island and offshore, New Zealand
Authors: Cousens Brian L. , Timm Christian , Abraham Ashley , Trenkler Matthew , Boame Michael M. , Papanicolaou Euri , Spencer Joey , Lacoursiere Anique , Emon Quinn 
Published: June 2023

Abstract
Mid- to late-Miocene continental arc volcanism on the North Island of New Zealand is found in the Coromandel Peninsula, the Kiwitahi volcanic chain and the Taranaki Basin (Kora Volcano) offshore the western margin of the North Island. Coeval oceanic arc volcanism is also found along the offshore Colville Ridge/Kermadec Ridge north of New Zealand. This Pb–Sr–Nd–Hf isotopic study aims to evaluate mantle sources and potential crustal contaminants along these sections of the Miocene arc system. The Colville/Kermadec Ridge and Kora lavas have the lowest Sr (0.7029–0.7045) and highest Nd (0.51305–0.51292) ratios; the Coromandel and Kiwitahi lavas overlap (Sr = 0.704–0.706; Nd = 0.51268–0.51296). The Colville/Kermadec Ridge, Kora, and Coromandel/Kiwitahi rocks form three distinct arrays on Pb–Pb plots, all above the Northern Hemisphere Reference Line, but none trend towards local Mesozoic basement greywackes. Isotopic and trace element ratio variations suggest that subducted sediments are a component in Coromandel/Kiwitahi mafic lava sources. The younger, southern Kiwitahi lavas have a more depleted mantle source than that for the older, northern Kiwitahi chain. Evolved lavas commonly have interacted with Waipapa basement rocks. Kora rocks have compositions similar to those of back-arc lavas and have been emplaced as sills in a rift environment above a distinct subduction-modified mantle.
Progressive Spreading of DNA Methylation in the GSTP1 Promoter CpG Island across Transitions from Precursors to Invasive Prostate Cancer
Authors: Gupta Harshath , Inoue Hitoshi , Nakai Yasutomo , Nakayama Masashi , Jones Tracy , Hicks Jessica L. , Kumar Balasubramanian , Gurel Meltem , Nelson William G. , De Marzo Angelo M. , Yegnasubramanian Srinivasan 
Published: June 2023

Abstract

Glutathione S-transferase pi 1 (GSTP1) is lowly expressed in normal prostate luminal cells and becomes induced in most proliferative inflammatory atrophy (PIA) lesions. GSTP1 becomes silenced in prostatic intraepithelial neoplasia (PIN) and prostate adenocarcinoma (CaP) via cytosine-phospho-guanine (CpG) island promoter hypermethylation. However, GSTP1 methylation patterns in PIA and PIN, and their relationship to patterns in CaP are poorly understood. We used bisulfite genomic sequencing to examine patterns of GSTP1 promoter CpG island methylation in laser capture microdissected benign, PIA, PIN, and CaP regions from 32 subjects that underwent radical prostatectomy. We analyzed 908 sequence clones across 24 normal epithelium, 37 PIA, 18 PIN, and 23 CaP regions, allowing assessment of 34,863 CpG sites with allelic phasing. Normal and PIA lesions were mostly unmethylated with 0.52 and 1.3% of total CpG sites methylated, respectively. PIN and CaP lesions had greater methylation with 24% and 51% of total CpG sites methylated, respectively. The degree of GSTP1 methylation showed progression from PIA &lt;&lt; PIN &lt; CaP. PIN lesions showed more partial methylation compared with CaP lesions. Partially methylated lesions were enriched for methylation changes at AP1 and SP1 transcription factor binding sites. These results demonstrate that methylation density in the GSTP1 CpG island in PIN was intermediate relative to that in normal prostate epithelium/PIA and CaP lesions. These results are consistent with gradual spreading of DNA methylation centered at the SP1/AP1 transcription factor binding sites in precursor lesions, with subsequent spreading of methylation across the entire CpG island in transition to CaP.

Prevention Relevance:
DNA hypermethylation at the GSTP1 promoter progressively spreads from being unmethylated in normal prostate to intermediate levels in precursor lesions to extensive methylation in cancer. This molecular progression of GSTP1 promoter methylation patterns in early prostate carcinogenesis could be useful for identification and interception of prostate cancer precursors.
A cost-effective and optimized maximum powerpoint tracking system for the photovoltaic model
Authors: Puttalingaiah Yoganandini Arehalli , Shesadri Anitha Gowda 
Published: June 2023

<span lang="EN-US">Solar energy is naturally available from sun, and it can be extracted by using a photovoltaic (PV) cell. However, solar energy extraction entirely depends on the climatic conditions and angle of rays falling on PV cells. Hence, maximum powerpoint tracking (MPPT) is considered in most areas under variable climatic conditions, which acts as a controller unit for PV cells. MPPT can enhance the efficiency of PV cells. However, designing an MPPT model is challenging as different uncertainties in the climatic condition may lead to more fluctuations in voltage and current in PV cells. Under the shaded condition, the PV cell may have other MPPT points that lead to the PV cell’s low efficiency in analyzing maximum power. Hence, this paper introduces a cost-effective and optimized system for the PV model that can find optimal power and improve PV cells’ efficiency. The proposed system achieves better computational performance with ~35% and ~42% than existing MPPT techniques. The improved particle swarm optimization (PSO) is smoother due to the enhanced form of MPP tracking. Hence, improved PSO takes 0.038 sec while the existing PSO technique takes 0.045 sec to obtain the MPP tracking.</span>