bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hedging risks in the C‐ITS road‐side unit investment case for Flanders: A real options approach
Authors: Degrande Thibault , Colle Didier , Verbrugge Sofie 
Published: August 2023

AbstractCooperative intelligent transport systems (C‐ITS) deployments for vehicle‐to‐infrastructure communication require substantial investments from European Member States in road‐side units (RSUs) and in central traffic management systems. The promise of numerous societal benefits should justify these public investments. However, C‐ITS uptake in passenger cars, and thus the subsequent societal benefits, are highly uncertain. Therefore, here, a case study of Flanders is presented in which real option analysis) is used to help road authorities assess the RSU investment opportunity. The framework combines a detailed cost and benefit model and includes managerial options for the road authority. This technique aims to incorporate the value of the flexibility that is available during the deployment to reduce risk exposure, and as such more accurately appraise the investment. C‐ITS uptake in passenger cars was modelled as the major source of uncertainty, as it is the primary driver of societal benefits. While a static RSU investment analysis for Flanders, Belgium, was found to be negative, embedding the option to defer the investment decision to further study C‐ITS uptake results in a positive average net present value. The results are useful for any road authority aspiring to roll out C‐ITS road‐side infrastructure.
Highly sensitive multifunction protection coordination scheme for improved reliability of power systems with distributed generation (PVs)
Authors: Alasali Feras , El‐Naily Naser , Saidi Abdelaziz Salah , Itradat Awni , Holderbaum William , Mohamed Faisal A. 
Published: August 2023

AbstractThe high penetration of distribution generators (DGs), such as photovoltaic (PV), has made optimal overcurrent coordination a major concern for power protection. In the literature, the conventional single or multi‐objective function (OF) for phase overcurrent relays (OCRs) scheme faces challenges in terms of stability, sensitivity, and selectivity to handle the integration of DGs and ground fault scenarios. In this work, a new optimal OCR coordination scheme has been developed as a multifunction scheme for phase and ground events using standard and non‐standard tripping characteristics. This research introduces and validates a coordinated optimum strategy based on two new optimization approaches, the Tug of War Optimization algorithm (TWO) and the Charged System Search algorithm (CSS), to mitigate the effects of DGs on fault currents and locations across the power network. Industrial software is used to create a case study of a CIGRE power network equipped with two 10 MW PV systems, and the results of the proposed new optimum coordination scheme are compared to traditional schemes. The findings show that the proposed multifunction OCR scheme is able to reduce the tripping time of OCRs over different fault and grid operation scenarios and increase the sensitivity of the relays in islanding operation mode.
Young nearby open clusters and their luminosity functions
Authors: Žerjal M. , Lodieu N. , Pérez-Garrido A. , Olivares J. , Béjar V. J. S. , Martín E. L. 
Published: August 2023

Context. Open clusters are groups of coeval stars sharing properties such as distance and metallicity, and they are key to understanding stellar evolution.
Aims. Our main goal is to study the evolution of open clusters with a special focus on the universality of the luminosity function.
Methods. We applied an upgraded version of the convergent point technique on about 50 open clusters. The selection of cluster members was based purely on the exquisite astrometry of the Gaia DR3 and HIPPARCOS catalogues in the five-dimensional or full six-dimensional space.
Results. We present updated lists of bona fide members of ∼50 open clusters within 500 pc and younger than 1 Gyr, exploiting the full depth of the third Gaia data release complemented by HIPPARCOS at the bright end, excluding regions in the Galactic plane. Our catalogues also are complemented by optical and infrared photometry from the major large-scale public surveys. All the data will be made available on a dedicated webpage with interactive plots and a direct link to Aladin and Vizier hosted at the Centre de Données de Strasbourg. We derived luminosity functions for all bound clusters and compared them in three age groups of ∼50 Myr, ∼150 Myr, and ∼600 Myr, discussing similarities and differences to constrain their dynamical evolution.
Conclusions. Luminosity functions of clusters at 50 Myr are more likely similar to each other and show a greater degree of similarity than older clusters. We explain this observation with the universal luminosity function within the volume of our sample (500 pc). Luminosity functions of clusters with ages similar to the Pleiades or Hyades are more diverse, perhaps due to internal dynamical evolution, but more work is needed to provide additional evidence.
Ventricular Function Determination During Extracorporeal Membrane Oxygenation (ECMO) Following Norwood Operation: A Case Report
Authors: Sistino Joseph J. , Smyre Jonathan T. , Patel Kirti 
Published: August 2023

Extracorporeal membrane oxygenation has been used successfully to support both cardiac and pulmonary function following Stage I Norwood operation. Determination of the return of native cardiac function and pulmonary function can be easily accomplished because of the single ventricle physiology. The pulmonary function can be assessed while on full flow ECMO by isolating the membrane oxygenator gas compartment, allowing evaluation of native pulmonary gas exchange through the modified Blalock–Taussig shunt. Cardiac output can be calculated by using the following oxygen delivery equation: Total O2 delivery ECMO oxygen delivery + ventricular oxygen delivery. The ventricular O2 saturation used in the formula for oxygen delivery is same as the mixed venous O2 saturation returning to the ECMO pump because of the large atrial communication following the Norwood operation.
A 3.2 kilogram patient was placed on a pediatric ECMO circuit utilizing a heparin-coated centrifugal pump and a microporous membrane oxygenate after failure to wean from bypass because of a low oxygen saturation and poor ventricular function. On day 1 of support, the systemic arterial oxygen saturation was 100% and matched the ECMO arterial saturation. On day 2 of the support, the patient's arterial saturation decreased to 96%, and the ECMO mixed venous saturation was 87%. Using the oxygen delivery formula, the ventricular cardiac output was calculated to be 175 mL/min, with an ECMO flow of 400 mL/min for a total cardiac output of 575 mL/min. The native ventricular contribution was, therefore, 30% of total cardiac output. Calculation of cardiac output would normally require a left ventricular sample in a patient with biventricular physiology. The single ventricle physiology in the post-operative Norwood patient makes this calculation a useful tool for assessing return of ventricular function in these patients.
Effect of fracture level on the residual fracture gap during tibial intramedullary nailing for tibial shaft fractures
Authors: Albayrak Kutalmis , Misir Abdulhamit , Alpay Yakup , Buyuk Abdul Fettah , Akpinar Evren , Gursu Sukru Sarper 
Published: August 2023

Introduction: The development of fracture gap during intramedullary nailing in tibial fractures is associated with poor fracture fragment contact and increased time to union and complications. This study aimed to evaluate the effect of the fracture level in the development of the fracture gap and the effect of the fracture gap on pain, radiologic and functional outcomes, and complication rate. Material and method: A total of 45 patients who underwent reamed intramedullary nailing due to closed transverse or short oblique tibial shaft fractures were divided into the proximal fracture group and the distal fracture group. The correlations between the visual analog scale (VAS) score, modified radiograph union score for tibias (RUST), and postoperative 1-year lower extremity functional scale scores, residual fracture gap, and time to union were evaluated. Results: The mean fracture gap amounts in the immediate postoperative anteroposterior and lateral radiographs were 5.6 ± 1.7 and 6.0 ± 1.7 mm in proximal fractures and 0.3 ± 2.4 mm and 0.4 ± 2.3 mm in distal fractures, respectively (p < 0.001 and p < 0.001, respectively). The mean time to union was 21.9 ± 2.9 weeks in the proximal fracture group and 16.7 ± 2.4 weeks in the distal fracture group (p < 0.000). The residual fracture gap amount significantly correlated with the level of fracture (r = 0.811, p < 0.001). Discussion: Tibial shaft fractures proximal to the isthmus level tend to develop significantly larger fracture gaps than distal fractures. It is associated with increased time to union and radiographic union scores as well as slightly higher complication and reoperation rates.
Retrospective evaluation of surgical site infection after open
splenectomies with and without perioperative prophylactic antibiotic
coverage
Authors: Husi Benjamin Andrea , Arnaldi Laura , Roitner Moritz , Nolff Mirja Christine 
Published: August 2023

Abstract
Objectives Perioperative prophylactic antibiotics (PPA) are widely used in
veterinary medicine to prevent surgical site infections (SSI). Current
guidelines advocate the use in clean procedures only if surgeries exceed
90 minutes, or in patients with an ASA score ≥3. Procedure
specific recommendations are currently lacking. The following study aimed to
analyze the protective effect of PPA in dogs undergoing open splenectomy.
Methods The electronic database of our institution was searched for dogs
that underwent splenectomy between 10/2017 and 01/2023. Data
collection included age at presentation, breed, weight, reason for splenectomy,
diagnosis, ASA class, PPA regime, surgery time, anesthesia time, lowest blood
oxygen concentration during anesthesia, lowest body temperature, and lowest
blood pressure during surgery as well as duration of hospitalization. Dogs were
included if a follow-up of 30 days after surgery was available, or if death
occurred within this timeframe.
Results A total of 112 dogs were included. Of these, 46 dogs received PPA,
and 66 did not. Most dogs were classified ASA 3 or higher (PPA 87%,
non-PPA 80.3%). One SSI (1.5% SSI rate) occurred in the non-PPA
group (overall SSI rate 0.9%). Due to the low SSI rate, statistical
analysis of risk factors for SSI development was not possible.
Conclusion The described infection rate of 1.5% without PPA
indicates, that splenectomy does not qualify as high-risk surgery for SSI, even
in patients with ASA class 3 or higher.
Clinical Relevance As splenectomies are frequently performed, the findings
of the current study could have a major impact on the overall antimicrobial
burden in routine veterinary practice.
Surgical removal of an atypical histiocytic cell proliferation in a
bearded dragon (Pogona vitticeps)
Authors: Digwa Kathrin , Wittenberg-Voges Liza , Hansmann Florian , Fehr Michael 
Published: August 2023

AbstractA 4-year-old female bearded dragon (Pogona vitticeps) was referred to the
Clinic for Small Mammals, Reptiles and Birds of the University of Veterinary
Medicine, Hannover, Germany for diagnostics and treatment of a growing mass in
the right cervical region. The owner reported that the mass had grown over the
past 4 weeks with only little alteration in the lizard´s behavior when
the animal started rubbing its neck against the cage equipment. Physical
examination as well as ultrasonographic and computed tomographic diagnostics
revealed a highly vascularized mass, which allowed for the hypothesis of an
aneurysm or a neoplasia. Complete surgical resection of the mass could be
performed uneventfully. The bearded dragon recovered well from anesthesia and
the surgical procedure. The microbiological sample of the excised mass revealed
Group F-67 Salmonella. Histopathological examination of the excised mass
revealed a histiocytic cell proliferation with centrally located blood filled
cavities, hemorrhages and granulation tissue resembling features of a
pseudoaneurysm. This report describes the diagnosis of an atypical growing mass
in a bearded dragon and its successful removal.
A Real-World Molecular Epidemiological Study of Non-Small-Cell Lung Cancer (NSCLC) Patients from Western India
Authors: Joshi Ashish , Korgavkar Reshma , Joshi Kshitij , Maniar Vashishth , Kalaskar Pritam , Kendre Pradip , Maheshwari Udip Dilip , Pethe Chandrashekhar , Sheth Smith , Dhande Sonal 
Published: August 2023

Background The molecular characterization of advanced non-small-cell lung cancer (NSCLC) has unveiled genomic alterations such as EGFR gene mutations, KRAS gene mutations, ROS1 gene rearrangements, EML4-ALK rearrangements, and altered MET signaling. The objective of this molecular epidemiological study was to report the clinical, pathological, and molecular profile of NSCLC patients from western India.
Materials and Methods This real-world study of NSCLC patients was performed at a chemotherapy day-care center in western India. The clinical, pathological, and molecular data were collected from the patient's medical records after obtaining the Ethics Committee permission for the study. The study was conducted according to the ethical principles stated in the latest version of Helsinki Declaration, and the applicable guidelines for good clinical practice.
Results A total of 182 (58.7%) men and 128 (41.3%) women with a median age of 63 years (range: 22–93 years) were included in the study. Of the total 310 patients, 195 (62.9%) were nonsmokers whereas 81 (26.1%) had a past history of smoking. EGFR, EML4-ALK Fusion Gene, KRAS, ROS1 gene rearrangement, and PD-L1 were positive in 42 (22.3%), 12 (9%), 2 (28.6%), 3 (12.5%), and 3 (25%) patients, respectively. One patient had concurrent EGFR mutation along with ROS1 gene rearrangement.
Conclusion Oncogenic driver mutations are present in Indian NSCLC patients. Molecular testing should be performed for all patients of advanced NSCLC to identify those that can benefit from newer generation of targeted or immunotherapies.
Primary Intraosseous Synovial Sarcoma: Experience from a Tertiary Cancer Center
Authors: Ramanujan Vishnu , Soma Srikanth , Krishnan Chandra Kumar , Malik Kanuj , Radhakrishnan Venkatraman , Raja Anand 
Published: August 2023

Introduction Primary intraosseous synovial sarcoma (PISS) is a rare cancer of the bone, with few reported cases across literature. Data from our institute reveals seven indigenous cases. This study aims to evaluate these PISS diagnoses, and to further investigate any histopathological findings and prognostic factors associated with patient survival.
Materials and Methods Data from patients diagnosed with PISS at the institute were obtained from January 1995 to December 2016, in the form of a retrospective study. Patient demographics, pathology locations, histological findings, surgical margins, and treatment modalities were audited as variables that can impact patient survival.
Results This research identified seven cases which fulfilled the diagnostic criteria and were subsequently classified as PISS of the bone. There were five men and two women among the cases, with ages ranging from 16 to 46 years, with a mean of 29.6 years. The study found that the lower limb was the most affected site in PISS, followed by the pelvis. Limb salvage was performed in six patients and one patient underwent amputation. Of these patients, six received adjuvant chemotherapy and four received adjuvant radiation as per institution guidelines. The study found that the 5-year disease-free and overall survival rate was 80 and 61%, respectively.
Conclusion PISS is a rare malignancy with limited cases in literature, and hence, there is no evidence for a standardized management protocol. The survival rates were similar between soft tissue and intraosseous synovial sarcoma among the case series.
Phase 1/2 Study of the Timing and Efficacy of 3 mg Peg-GCSF in Neo/Adjuvant Dose Dense Breast Cancer Treatment Protocols
Authors: Patel Amol , Pathak Abhishek , Sarin Arti , Shelly Divya , Ranjan Richa , Singh Arashdeep , Kala Tripti , PV Babitha 
Published: August 2023

Background Peg-GCSF has similar efficacy at a dose of 60 µg/kg and 100 µg/kg. The conventional 6 mg SC dose was based on the maximum tolerable dose. In Japan, 3.6 mg dose was approved on the basis of dose finding studies. Peg-GCSF is an integral part of dose-dense chemotherapy protocols. Dose finding and scheduling study of peg-GCSF have not been conducted in Indian patients.
Materials and Methods We conducted two-center phase 1/2 clinical study addressing the timing and efficacy of peg-GCSF in Indian breast cancer patients (CTRI no: 2021/07/034751). Three groups of timing administration were studied, namely 1, 6, and 24 hours post chemotherapy. The phase 2 part was the expansion of the best timing group. The primary objective was dose density, which was defined as receiving chemotherapy on < 3 days of scheduled date. Adriamycin/epirubicin cyclophosphamide (AC/EC) was administered q2 weeks. The total leucocyte (TLC) and absolute neutrophil (ANC) kinetics were studied. Other outcomes were incidence of grade 4 neutropenia, febrile neutropenia (FN), and requirement of additional doses of G-CSF. Bone pain, fever, and myalgia were studied for adverse effects.
Results From November 20 to December 21, 36 patients were enrolled. Patient characteristics are depicted in Table 1. Initially, three patients received the peg-GCSF in each timing group. One patient in each 1-hour and 6 hours needed G-CSF support for maintaining the dose density. The 24-hour group was carried to phase 2 part. Dose density was maintained in 97% of patients. None of the patient in 24-hour group had FN. Also, 4/30 patients had grade 4 neutropenia and required an additional dose of GCSF. Grade 3 or 4 bone pain was not noticed by any of the patients. During the first cycle, the mean ANC (cells/μL) was 5284, 20704, 3010, 6954 on D0, D + 3, D + 7, and D + 13, respectively (Fig. 1A-TLC and 1B-ANC). The mean ANC (cells/μL) rise on D + 3 in cycles 1, 2, 3, 4 was 23810, 29209, 32428,22455, respectively.
Conclusion Dose density of AC/EC breast cancer protocol is maintained with peg-GCSF 3 mg. Post chemotherapy 24-hour timing of peg-GCSF administration remains as the standard. A phase 3 trial of 6 mg versus 3 mg is warranted.
Survival Outcome and Predictors of Survival in Elderly Breast Cancer Patients following Curative Treatment
Authors: T.M Anoop , Joseph P Rona , K.R Rajeev , Soman Saikumar , Mathew Mintu , Chacko Steffi , Kumar Bhavya S. 
Published: August 2023

Objectives The lack of data on management of elderly breast cancer patients' population makes most oncologists reluctant to treat them with the standard treatment protocols as advised for the younger patients. This study was done to identify the survival outcome and predictors of survival in elderly breast cancer patients treated with curative intent.
Materials and Methods Newly diagnosed patients with breast cancer aged more than 65 years who received treatment with curative intent were included. Disease-free survival (DFS) and overall survival were estimated using the Kaplan–Meier method. Survival curves were compared using log-rank test. Cox regression analysis was done to find out the predictors of DFS.
Results This study included 112 elderly breast cancer patients. In our patient population, 79 (70.5%) were less than or equal to 70 years of age and 33 (29.5%) were more than or equal to 70 years. Median age was 68 years. Charlson comorbidity index score was six and above in 31 (28.1) patients. Median DFS in our study was 46 months. Median DFS was not reached in patients less than or equal to 70 years of age, whereas it was 50 months (47–53) among patients more than or equal to 70 years of age, p-value-0.009. In univariate analysis, age more than or equal to 70 years and locally advanced breast cancer were the predictors of DFS with hazard ratio (HR) of 2.8 (1.2–6.69), p-value 0.013 and 2.9 (1.12–7.6), and 0.027, respectively. In multivariate analysis, age more than or equal to 70 years was the only significant predictors of DFS with HR of 2.8 (1.2–6.5) and p-value of 0.015.
Conclusion Standard curative intent treatment was well tolerable among elderly patents. Elderly age more than 70 years was a unique predictor of DFS. We need to incorporate tools to assess life expectancy and functional status that will help us predict toxicity of treatment and survival advantage more precisely.
Polymorphism of XRCC7 Gene and Risk of Glioma: A Prospective Case–Control Study
Authors: Choudhary Deepak , Mahajan Bhawna , Sumi Mamta , Dholakia Binita , Bhandari Sumit , Ghimire Niraj , Saluja Sundeep , Bodeliwala Shaam , Wani Wajid Nazir , Jagetia Anita 
Published: August 2023

Abstract
Objective The aim of this study is to determine association between polymorphism of XRCC7 gene and glioma.
Materials and Methods A case–control study was designed to analyze the prevalence of the various XRCC7 genotypes in 30 cases of histologically proven glioma and 30 age- and sex matched controls.
Result There is significantly higher prevalence of the GT and the TT genotypes of XRCC7 gene in cases of glioma as compared with control. The prevalence was significantly pronounced in two subgroups–middle aged and male gender. The presence of the XRCC7 GT or TT genotype conferred a significantly higher risk of developing glioma (odds ratio: 13.021,2.114–80.213).
Conclusion The presence of the T allele in XRCC7 polymorphism may increase the susceptibility to glioma.
Bilateral Inferior Turbinate Flaps for Salvage Reconstruction after Proton Beam Radiotherapy for Clival Chordoma
Authors: Crawford Kayva L. , Saripella Megana , DeConde Adam S. , Beaumont Thomas L. 
Published: August 2023

AbstractClival chordoma is a rare, aggressive, notochord-derived tumor primarily managed with surgery via an endoscopic endonasal approach (EEA) and adjuvant proton beam radiotherapy. Reconstruction is commonly performed with a nasoseptal flap (NSF) at the time of initial surgery. While failures of the NSF are rare, they can occur following the initial surgery or in the setting of osteoradionecrosis. Salvage repair typically requires transfer of alternative vascularized tissues outside of the previously radiated field including regional scalp flaps such as pericranial or temporoparietal fascial flaps, or free vascularized tissue transfer. Here we describe the case of a 29-year-old woman with a history of clival chordoma with widespread skull base osteomyelitis secondary to NSF necrosis after proton beam radiotherapy. We describe successful skull base reconstruction with intranasal bilateral inferior turbinate flaps based on the sphenopalatine artery with lateral nasal wall extension, despite prior proton beam therapy and a failed prior vascularized intranasal reconstruction.