bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of mortality and high-risk characteristics of thyroid cancer in Filipinos using the California Cancer Registry
Authors: Hsu Robert , Tsai Kai-Ya , Chennapan Krithika , Wojcik Katherine Y. , Lee Alice W. , Nieva Jorge J. , Liu Lihua 
Published: January 2023

IntroductionFilipinos are the third largest Asian American subgroup and have the highest incidence of thyroid cancer among all races. To better understand this racial/ethnic disparity in thyroid cancer affecting Filipinos we analyzed the California Cancer Registry (CCR) data in Filipino thyroid cancer cases from 1988 to 2018.Methods97,948 thyroid cancer cases in California from 1988 to 2018 (until 2015 for Asian subgroups) were evaluated. We examined the case distribution by sex, age at diagnosis, race/ethnicity including Asian ethnic subgroups, histology, TNM stage, tumor size, lymph node involvement, lymphovascular invasion, and multifocality. We also looked at treatment data including surgery and radiation including radioactive iodine therapy. We calculated age-adjusted mortality rates (AAMR) for each major racial group and each Asian ethnic subgroup. Binary logistic regression was used to determine the likelihood of high-risk characteristics and treatment when comparing Filipinos to other racial/ethnic groups. Kaplan-Meier Estimate was performed to evaluate thyroid cancer survival across all race/ethnicities. Multivariate Cox proportion hazards regression was performed to evaluate mortality risk from all causes of death by race.ResultsThere were 5,243 (5.35%) Filipino thyroid cancer cases in California from 1988 to 2018. Filipinos had the highest AAMR (1.22 deaths per 100,000) in 2015. Filipinos had a higher likelihood of Stage IV thyroid cancer compared with Non-Hispanic Whites, Non-Hispanic Blacks, Hispanics and nearly all Asian subgroups. Filipinos had a worse 5-year and 10-year overall survival (OS) than the combination of all other Asian/Pacific Islanders. Filipinos compared to Non-Hispanic Whites had significant mortality risk in overall and papillary thyroid cancer cases (Overall HR: 1.10, 95% CI 1.07–1.13, p &lt; 0.0001, Papillary HR: 1.11, 95% CI 1.07–1.14, p &lt; 0.0001) when adjusted for race/ethnicity, age, gender, socioeconomic status, and stage. When stratified by Charlson comorbidity score, Filipinos compared to Non-Hispanic Whites still had significant mortality risk (Charlson 0 HR: 1.07, 95% CI 1.02–1.11, p = 0.0017, Charlson 1+ HR: 1.07 95% CI 1.002–1.14, p = 0.0434).ConclusionsFilipino thyroid cancer patients have higher incidences of high-risk pathological features and greater AAMR and mortality risk. These findings warrant further investigation into better understanding the connection between the greater incidence of high-risk characteristics and increased mortality in Filipinos.
Association between occupation type and development of type 2 diabetes: A population-based Panasonic cohort study 3
Authors: Habu Momoko , Okada Hiroshi , Hamaguchi Masahide , Kurogi Kazushiro , Murata Hiroaki , Ito Masato , Fukui Michiaki 
Published: January 2023

BackgroundDue to a lack of investigation on the association between the type of occupation and the development of type 2 diabetes among Japanese individuals, we aimed to assess this association in 98,935 Japanese individuals.MethodsThis long-term retrospective cohort study included participants selected from medical health checkup programs conducted at the Panasonic Corporation, Osaka, Japan, from 2008 to 2018. Cox regression analyses were used to evaluate the association between occupation type and the incidence of type 2 diabetes.ResultsFrom 2008 to 2018, 5,008 participants developed type 2 diabetes. The proportion of never smokers, those with slow eating speeds, and those working with a flextime system was higher in men with technical jobs than in salespersons, manufacturers, and office workers (p &lt; 0.0001). Cox regression analyses revealed that occupation type was associated with an increased probability of type 2 diabetes development in men but not in women. Multivariate analyses showed that the hazard ratios were 1.15 [95% confidence interval (CI), 1.05–1.26], 1.20 (95% CI, 1.10–1.30), and 1.11 (95% CI, 1.02–1.21) in men working as salespersons, manufacturers, and office workers, respectively (reference group: men with technical jobs). On the other hand, the occupation type was not associated with the development of type 2 diabetes in women.ConclusionsThis study demonstrated that occupation type might be an independent factor in the development of type 2 diabetes in Japanese men.
Using Machine Learning to Predict Cognitive Impairment Among Middle-Aged and Older Chinese: A Longitudinal Study
Authors: Liu Haihong , Zhang Xiaolei , Liu Haining , Chong Sheau Tsuey 
Published: January 2023

Objective: To explore the predictive value of machine learning in cognitive impairment, and identify important factors for cognitive impairment.Methods: A total of 2,326 middle-aged and elderly people completed questionnaire, and physical examination evaluation at baseline, Year 2, and Year 4 follow-ups. A random forest machine learning (ML) model was used to predict the cognitive impairment at Year 2 and Year 4 longitudinally. Based on Year 4 cross-sectional data, the same method was applied to establish a prediction model and verify its longitudinal prediction accuracy for cognitive impairment. Meanwhile, the ability of random forest and traditional logistic regression model to longitudinally predict 2-year and 4-year cognitive impairment was compared.Results: Random forest models showed high accuracy for all outcomes at Year 2, Year 4, and cross-sectional Year 4 [AUC = 0.81, 0.79, 0.80] compared with logistic regression [AUC = 0.61, 0.62, 0.70]. Baseline physical examination (e.g., BMI, Blood pressure), biomarkers (e.g., cholesterol), functioning (e.g., functional limitations), demography (e.g., age), and emotional status (e.g., depression) characteristics were identified as the top ten important predictors of cognitive impairment.Conclusion: ML algorithms could enhance the prediction of cognitive impairment among the middle-aged and older Chinese for 4 years and identify essential risk markers.
Effects of dual therapy with betamethasone and tetracycline in a NC/Nga mouse model of atopic dermatitis
Authors: Matsui Katsuhiko , Kobayashi Mahoka , Nagano Mari , Matsuoka Mio 
Published: January 2023

Purpose: Our previous study has demonstrated that tetracycline exerts excellent bactericidal activity against Staphylococcus aureus strains isolated from patients with atopic dermatitis (AD) while simultaneously inhibiting the development of T helper (Th) type 2 (Th2) cells. The present study was designed to evaluate the effectiveness of dual therapy with betamethasone and tetracycline for AD.Methods: Betametasone (0.1%) and tetracycline (3%) were topically administered to NC/Nga mice with AD-like skin lesions. Skin severity scores, histological changes to the lesioned skin, and serum IgE levels were assessed as indicators of therapeutic effectiveness.Results: Topical treatment with both drugs reduced the skin severity score more significantly than was the case with betamethasone alone or tetracycline alone. This was associated with a reduction in the degree of epidermal thickening, the density of cellular infiltration into the dermis, the mast cell count in the dermis and the serum IgE concentration. Furthermore, the degree of Th1/Th2 cell development in auricular lymph nodes and the S. aureus count on the lesioned skin were synergistically suppressed by simultaneous application of both drugs.Conclusion: The present results show that simultaneous topical application of betamethasone and tetracycline synergistically ameliorates AD-like skin lesions in NC/Nga mice. This suggests that dual therapy with betamethasone and tetracycline for AD lesions colonized by S. aureus might be one of the best options for inhibiting the development of both Th1 and Th2 cells and acting on superficially located S. aureus.
Genomic Diversity among Actinomyces naeslundii Strains and Closely Related Species
Authors: Mughal Sadaf Rasheed , Niazi Sadia Ambreen , Do Thuy , Gilbert Steven C. , Didelot Xavier , Radford David R. , Beighton David 
Published: January 2023

The aim of this study was to investigate and clarify the ambiguous taxonomy of Actinomyces naeslundii and its closely related species using state-of-the-art high-throughput sequencing techniques, and, furthermore, to determine whether sub-clusters identified within Actinomyces oris and Actinomyces naeslundii in a previous study by multi locus sequence typing (MLST) using concatenation of seven housekeeping genes should either be classified as subspecies or distinct species. The strains in this study were broadly classified under Actinomyces naeslundii group as A. naeslundii genospecies I and genospecies II. Based on MLST data analysis, these were further classified as A. oris and A. naeslundii. The whole genome sequencing of selected strains of A. oris (n = 17) and A. naeslundii (n = 19) was carried out using Illumina Genome Analyzer IIxe and Roche 454 allowing paired-end and single-reads sequencing, respectively. The sequences obtained were aligned using CLC Genomic workbench version 5.1 and annotated using RAST (Rapid Annotation using Subsystem Technology) release version 59 accessible online. Additionally, genomes of seven publicly available strains of Actinomyces (k20, MG1, c505, OT175, OT171, OT170, and A. johnsonii) were also included. Comparative genomic analysis (CGA) using Mauve, Progressive Mauve, gene-by-gene, Core, and Pan Genome, and finally Digital DNA-DNA homology (DDH) analysis was carried out. DDH values were obtained using in silico genome–genome comparison. Evolutionary analysis using ClonalFrame was also undertaken. The mutation and recombination events were compared using chi-square test among A. oris and A. naeslundii isolates (analysis methods are not included in the study). CGA results were consistent with previous traditional classification using MLST. It was found that strains of Actinomyces k20, MG1, c505, and OT175 clustered in A. oris group of isolates, while OT171, OT170, and A. johnsonii appeared as separate branches. Similar clustering to MLST was observed for other isolates. The mutation and recombination events were significantly higher in A. oris than A. naeslundii, highlighting the diversity of A. oris strains in the oral cavity. These findings suggest that A. oris forms six distinct groups, whereas A. naeslundii forms three. The correct designation of isolates will help in the identification of clinical Actinomyces isolates found in dental plaque. Easily accessible online genomic sequence data will also accelerate the investigation of the biochemical characterisation and pathogenesis of this important group of micro-organisms.
Las competencias digitales para mejorar estrategias de enseñanza en los docentes de Ciencias Sociales
Authors: Mendoza-Mendoza Fernando Ramón , De-la-Peña-Consuegra Geilert , Zambrano-Acosta Jimmy Manuel 
Published: January 2023

El objetivo general de la presente investigación fue determinar las competencias digitales para mejorar estrategias de enseñanza en los docentes de Ciencias Sociales. Se desarrolló desde un enfoque cuantitativo, se apoyó en el análisis documental–bibliográfico. Es descriptiva, porque consiste en la caracterización de un hecho, fenómeno, individuo o grupo La población se conformó por los docentes de la Unidad Educativa Fiscal Cinco de Junio, ubicada en la parroquia Manta, del cantón de Manta, de la Provincia de Manabí en el año lectivo 2021 – 2022, formada por 60 docentes de ambos sexos. Así mismo, las técnicas aplicadas en este estudio fueron la encuesta y la observación. Además, se consideró el análisis de contenido de la información recopilada, lo que permitió la formulación de resultados. Se concluye que, el dominio de competencias digitales está inmerso en todos los ámbitos, principalmente en la educación, por lo que se requiere de docentes preparados.
Saudi Minister of Health's Speeches Regarding to Covid-19 Pandemic, a Study in Light of Speech Acts
Authors: Abdullatif Alhulaybi Abdulaziz , Hemame Belgacem 
Published: January 2023

The idea of the research proceeds from the fact that the linguistic discourse adopted by the Saudi Ministry of Health contributed - along with other factors - to overcoming the large and dangerous effects that left behind Covid-19. This success was witnessed internationally in multiple official reports, which made this Saudi experience pioneer and even deserved to study and analyze. In fact, the linguistic discourse adopted by the Saudi Ministry of Health had an important role in the interaction of Saudi society members and organizations, and their full commitment to the instructions and directives of the competent health authorities, which made it possible to overcome the effects of this pandemic. Accordingly, we intend to study this discourse in the light of the speech act theory, so that we can reveal (the performance power in this discourse), as well as the role of (implicit and presupposition), in achieving the required interaction with the addressee. The study found that results, including the predominance of (illocutionary acts) in the statements whether it is (declarative) or (performative). In addition, each of the nine discourses represented a fully illocutionary act, and the acts in these discourses are obvih, does, and free of semantic ambiguity. Moreover, the speaker invested in politeness strategies, especially positive ones, to save the face of the addressee to be treated by performing acts. Acknowledgment: The author acknowledges the Deanship of Scientific Research at King Faisal University for the financial support under Nasher Track (Grant No216113).
The relationship of the prevalence of caries with the immune status of preschool and schoolage children in the city of Makhachkala
Authors: Kosyreva T. F. , Osmanovа F. I. 
Published: January 2023

Relevance. The study of the relationship between dental morbidity and immune status is relevant due to the high prevalence of caries and the level of somatic health of children in Makhachkala.Materials and methods. The survey involved 425 children aged 2 to 17 years, long-term residents in Makhachkala. The average value of the CPI index corresponds to 5.5. To determine the relationship between the presence of caries and the immune status of children, 33 patients were selected from the examined to participate in a study to determine immunoglobulins in oral fluid in three age periods (11 children aged 6, 12 and 15 years). Oral fluid intake in patients was carried out 2 hours after meals. Determination of the concentration of immunoglobulins (secretory sIgA, IdA, IgM and IgG) was carried out using a set of reagents for enzyme immunoassay determination of the concentration of secretory immunoglobulins in "Invitro". Statistical analysis of the material was carried out using the IBM SPSS Statistics Standard program.Results. In Makhachkala, an increase in the prevalence of caries with age was revealed in preschoolers (6 years) 78.2 ± 0.3%, in adolescence (12 years) 78.9 ± 0.2%, in children with permanent bite (15 years) reaches 85.2 ± 0.6%. Studies of the immune status showed that immunoglobulins varied individually and by age groups. sIgA immunoglobulin, which allows to control immunity before the disease, decreased by more than 3 times by the period of permanent bite. Immunoglobulin IgA, which plays a protective function in humoral immunity, decreased by more than 70% by the period of permanent bite. IgM immunoglobulin increased by more than 40% in children by the age of 15. Changes also occurred with the content of the enzyme lysozyme, decreasing by the age of 15 years almost 6 times from the norm.Conclusions. The high morbidity rate of the children's population in Makhachkala is associated with anthropogenic impact, poor-quality drinking water, air and indicates the need for early detection of chronic somatic diseases and the organization of preventive and medical-dental care for children from an early age.
Formulasi Sediaan Permen Jahe (Zinger Officinale) Dari Hasil Budidaya Tanaman Obat Keluarga (TOGA) sebagai Antioksidan
Authors: Ginting Ovalina Sylvia Br. , Rambe Robiatun , Chairunnisa Riezky 
Published: January 2023

Sumber antioksidan banyak terdapat secara alami dalam bahan pangan salah satunya adalah jahe. Jahe (Zinger officinale) merupakan tanaman rempah yang kaya akan antioksidan yang berasal dari Asia Selatan, dan sekarang terlah tersebar ke seluruh dunia. penelitian mengemukakan bahwa sebagian orang tidak menyukai rimpang jahe langsung dikarenakan pada permen jahe komersial memiliki rasa yang sangat pedas serta kandungan vitamin C masih rendah sekitar 10,675 mg/100g. penelitian ini meningkatkan kandungan antioksidan (vitamin C) serta meminimalisir rasa pedas dari permen jeli ekstrak jahe. Penelitian ini merupakan jenis penelitian eksperimental. Parameter yang diamati dalam penelitian ini adalah uji organoleptik terdiri dari uji hedonik (kesukaan) dan analisis kandungan gizi proksimat (kadar air, kadar abu, kadar gula reduksi) serta kadar vitamin C pada permen jeli formula terbaik. Hasil yang diperoleh Penilaian organoleptik panelis lebih menyukai warna permen jahe perlakuan P3 dengan persentase tertinggi yaitu 100%. Hasil uji hedonik pada permen jahe dilakukan pada 25 orang panelis persentase penerimaan tertinggi terdapat pada permen jahe P3 yaitu 100% . Hasil analisis laboratorium pada permen jaheP3 meliputi analisis proksimat (kadar air, kadar abu, kadar gula reduksi) dan kadar vitamin C
FORMULASI DAN EVALUASI SEDIAAN LIPSTIK DARI EKSTRAK BUAH NAGA MERAH (Hylocereus polyrhizus) DAN EKSTRAK LIDAH BUAYA (Aloe vera) SEBAGAI PEWARNA DAN PELEMBAB ALAMI
Authors: Athaillah Athaillah , Sundari Dwi , Pangondian Aswan , Chandra Putra 
Published: January 2023

Buah naga merah (Hylocereus polyrhizus) memiliki kandungan kimia betasianin yang berfungsi sebagai pewarna alami dan lidah buaya (Aloe vera) juga memiliki turunan polisakarida yaitu lignin yang mana berfungsi sebagai pengikat kelembapan kulit. Kombinasi ekstrak buah naga merah dan lidah buaya dapat dibuat sebagai sediaan farmasi dalam bentuk lipstik. Tujuan penelitian ini yaitu untuk mengetahui konsentrasi optimum ekstrak buah naga merah dan lidah buaya terhadap sifat fisik lipstik. Penelitian ini merupakan penelitian eksperimental dengan tahapan pembuatan esktrak dengan metode maserasi dengan uji fitokimia betasianin pada buah naga merah dan metode infundasi dengan pula uji fitokimia lignin pada lidah buaya sebelum pembuatan lipstik. Pembuatan lipstik dengan 6 variasi konsentrasi ekstrak buah naga merah 30,25,20,15,10,5% (b/v) dan lidah buaya 5,10,15,20,25,30% (b/v) dan uji organoleptik, uji homogenitas, uji pH, uji oles,uji titik lebur, uji kekerasan, uji iritasi serta diuji stabilitas fisik sediaan lipstik dengan uji stabilitas 3 siklus. Hasil maserasi pada buah naga merah didapatkan 57 ml dan hasil infundasi lidah buaya yang didapatkan ialah 57 ml. Hasil uji fitokimia menunjukkan ekstrak buah naga merah positif mengandung betasianin dan ekstrak lidah buaya positif mengandung lignin. Formula (F) dalam penelitian ini ialah konsentrasi. Hasil penelitian menunjukkan konsentrasi ekstrak buah naga merah dengan uji organoleptik dengan formula 1 (F1) hingga formula 6 (F6) menghasilkan warna, bau dan bentuk yang baik. Hasil uji pH seluruh formula memiliki pH dibawah rentang standart pH kulit yaitu pH 8. Hasil uji oles menunjukkan seluruh formula memiliki daya oles yang baik. Hasil uji titik lebur menunjukkan formula 4 (F4) memiliki titik lebur 66̊ C.Hasil uji kekerasan menunjukkan hasil formula 6 (F6) menghasilkan daya tekstur yang kuat. Hasil uji iritasi menunjukkan seluruh formula tidak menghasilkan efek gatal hingga bengkak ketika dioleskan berturut-turut selama 3 hari dan hasil uji stabilitas menunjukkan formula 3 (F3) hingga formula 6 (F6) menghasilkan perubahan warna seperti memudar drastis dan tekstur melebur pada bawah sediaan, hal ini terjadi pada hari ke 4 berada pada suhu ekstrim. Formulasi optimum sediaan lipstik yang berada pada rentang standart ialah formula 1 (F1) dengan konsentrasi buah naga merah 30 % dan lidah buaya 5 %, sudah cukup baik dan bisa untuk diformulasikan sebagai sediaan lipstik.
Artysta – nauczyciel w działaniach z młodzieżą niepełnosprawną. Przyczynek do biografii
Authors: Boguszewska Anna 
Published: January 2023

Celem niniejszego artykułu jest ukazanie osoby nauczyciela i jego działalności na rzecz ucznia niepełnosprawnego. Nauczyciel Agnieszka Gadzińska-Kita w latach 1986-2021 prowadziła pozalekcyjne zajęcia artystycznych z zakresu plastyki wspierające rozwój młodzieży niepełnosprawnej. Jej systematyczna praca, z mozolnym, twórczym wysiłkiem przynosiła uczniom korzyści w rozwoju poznawczym, społecznym i emocjonalnym. Efekty nie są mierzalne. Terenem badań był Specjalny Ośrodek Szkolno-Wychowawczy dla Dzieci i Młodzieży Niepełnosprawnych im. Prof. Zofii Sękowskiej w Lublinie. Zarysowano rolę zajęć artystycznych o terapeutycznym znaczeniu. Próba rekonstrukcji takich działań obejmuje ogólny wgląd w proces dydaktyczny, preferencje wychowanków i osiągane przez nich efekty. Wykorzystano metody badań stosowanych w biografistyce oraz metodzie monografii pedagogicznej.
Personalistyczne i społeczne aspekty nauczycielstwa Natalii Tułasiewicz – w poszukiwaniu inspiracji dla współczesności
Authors: Jazukiewicz Iwona 
Published: January 2023

Biografistyka pedagogiczna jest skarbnicą wzorów postaci, które w codzienny i zarazem niezwykły sposób realizowały społeczną misję nauczania i wychowania. Celem artykułu jest uzasadnienie, że nauczycielstwo Natalii Tułasiewicz (1906-1945) jest godne włączenia do tej skarbnicy i może służyć jako ponadczasowy wzór postawy wobec wyzwań, które niesie każda rzeczywistość, bez względu na czas w kalendarzu.
Nie trzeba uzasadniać posiadania cnót przez Natalię, ponieważ ich heroiczność została udowodniona w procesie beatyfikacyjnym. Warto natomiast rozważyć związek cnót i zalet Natalii z jakością jej nauczycielskiej pracy. Priorytetowe dla tych rozważań uczyniono następujące cnoty i zalety Natalii: personalistyczne nastawienie; umiejętność dobrego bycia z ludźmi; patriotyzm; zdolność dostrzegania i przeżywania piękna przyrody, wytworów ludzkiej pracy i działalności twórczej; umiłowanie ciszy i samotności; refleksyjność, skrytość w uzewnętrznianiu uczuć i myśli, trafność i krytyczność obserwacji ludzi i zdarzeń, poczucie humoru; prostota, pokora i wdzięczność. Jako podstawowe źródło interpretacji nauczycielstwa Natalii Tułasiewicz wykorzystano cztery tomy jej pamiętnikarskich zapisków, obejmujące lata 1938-1943.
Wniosek z rozważań, będący jednocześnie przesłaniem dla współczesnego nauczyciela, jest następujący: Dobre nauczycielskie bycie Natalii polegało na czerpaniu szczęśliwości z wykonywania codziennych zadań społecznych i zawodowych przy wykorzystaniu swoich cnót jako bogactwa tego bycia.
Pedagogiczna refleksja nad rodziną w dorobku dwudziestu pięciu lat funkcjonowania Katedry Pedagogiki Rodziny w Instytucie Pedagogiki KUL
Authors: Opozda Danuta 
Published: January 2023

W artykule podejmowane są zagadnienia dotyczące udziału Katedry Pedagogiki Rodziny Instytutu Pedagogiki KUL w rozwoju pedagogicznej myśli o wychowaniu w rodzinie. Celem artykułu jest przedstawienie okoliczności powstania Katedry i profesorów, którzy mieli szczególne znaczenie w utworzeniu Katedry. Celem jest również prezentacja podstawowych założeń działalności naukowej i kierunków refleksji oraz zarys obszarów badań nad rodziną. Ważne jest też pytanie, jaka jest relacja między pedagogiką rodziny a naukami o rodzinie.