bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exposure to perfluoroalkyl and polyfluoroalkyl substances and risk of stroke in adults: a meta-analysis
Authors: Chang Min Cheol , Chung Seung Min , Kwak Sang Gyu 
Published: September 2023

Abstract

Introduction
Evidence of the adverse metabolic health effects of perfluoroalkyl and polyfluoroalkyl substances (PFAS) is increasing. However, the impact of PFAS on cardiovascular diseases remains controversial. This meta-analysis aimed to analyze the impact of PFAS on the stroke risk.

Content
Databases were searched for studies published up to November 1, 2022, which report the association between stroke and exposure to at least one of four main PFAS (perfluorooctanoic acid [PFOA], perfluorooctanesulfonic acid [PFOS], perfluorononanoic acid [PFNA], and perfluorohexane sulfonic acid [PFHxS]). Data extraction and quality assessment were performed according to the Newcastle-Ottawa scale.

Summary and outlook
Four studies were included in this systematic review. Multivariate adjusted odds ratios (ORs) for incident stroke per 1-log unit increment in each serum PFAS were combined in the meta-analysis. The risk of development of stroke was not significantly associated with PFOA, PFOS, or PFNA exposure (PFOA: pooled odds ratio [OR]=1.001, 95 % confidence interval [CI]=0.975–1.028, p=0.934; PFOS: pooled OR=0.994, 95 % CI=0.972–1.017, p=0.601; PFNA: pooled OR=1.016, 95 % CI=0.920–1.123, p=0.752), whereas a moderately lower risk was associated with PFHxS exposure without statistical significance (pooled OR=0.953, 95 % CI=0.908–1.001, p=0.054). PFOA, PFOS, and PFNA exposure showed a neutral association, while PFHxS showed a possible inverse association with the risk of stroke. Therefore, this finding should be interpreted with caution. Further prospective observational studies with PFAS mixture analyses are warranted.
Calling vocatives duration in Libolo Portuguese
Authors: Fernandes-Svartman Flaviane R. , Santos Vinícius G. , González-López Verónica A. , Rodrigues de Moraes Rafael , García Jesús E. , Tasca Gustavo H. 
Published: September 2023

Abstract
This paper aims to study two types of distinct vocatives in absolute position in Portuguese of Libolo (Angola), a barely studied African variety of Portuguese: the initial call and the insistent call. The results reveal that: (i) long postonic syllables characterize the two types of calls; (ii) there is greater variability in the duration of the postonic syllable of insistent calls; (iii) the duration is a robust correlate that distinguishes these two types of vocatives; and (iv) insistent calls are longer, both concerning the total duration of the utterance and in relation to the duration of each syllable (that is, there is an additive effect). These results are supported by statistical analyses. It was proved that the difference in duration between initial and insistent calls in Libolo Portuguese is statistically significant. Furthermore, Bayesian analyses not only conferred greater reliability on the results of the initial analyses, since it is a small dataset, but also provided a greater understanding of the relationship between the two types of vocatives, regarding the greater variability of results of the insistent call.
Static and dynamic analyses of velar palatalization in Chilean Spanish
Authors: Bolyanatz Mariška 
Published: September 2023

AbstractSome previous sociolinguistic work in Chilean Spanish has claimed that velar palatalization (i.e., production of a word likegente/xente/ ‘people’ as [çen̪.t̪e] or [xjen̪.t̪e]) is a categorical feature of all speakers of this dialect, while other scholars have argued that palatalization of /x/ is conditioned by sociolinguistic factors. The present study comprises a sociophonetic analysis of the production of /x/ across 61 speakers from Santiago, Chile in an effort to acoustically verify one of these two claims. Via the use of static and dynamic analyses of 2,107 tokens of /x/ in diverse phonological environments, this paper demonstrates that among these data, only linguistic factors condition the place of articulation and degree of constriction of /x/. Overall, /x/ palatalization before /e/ appears to be a gradient strengthening phenomenon generalized among the entire sample of Santiago Spanish speakers. Further, I argue that the dynamic analyses are superior both theoretically and methodologically as they allow for more faithful capturing of the variability inherent in the speech signal.
Conflicting standards and variability: Spirantization in two varieties of Uruguayan Spanish
Authors: Gilbert Madeline 
Published: September 2023

Abstract
Most sociolinguistic work on variation focuses on how rates of occurrence or mean measurements differ between speech communities and speakers. However, speakers and communities also differ in variability – that is, in dispersion around the mean. The current study investigates the effects of speech style and multilingualism on variation and variability, by measuring the degree of intervocalic /bdɡ/ spirantization in spontaneous and careful speech. Data come from two varieties of Uruguayan Spanish, one monolingual (Montevideo) and one in contact with Brazilian Portuguese (Rivera). The results from a variation analysis confirm expected linguistic and social effects on gradient spirantization. An analysis of variability shows that, at the group level, careful speech is more variable than spontaneous speech, and the data from Rivera is more variable than that from Montevideo. Variability at the individual level differs slightly, suggesting that the group-level variability arises from between-speaker variability and within-speaker variability in different contexts. I propose that multilingualism in Rivera may heighten variability because contact with Portuguese provides a wider range of available pronunciations, and that careful speech may increase variability because the available pronunciations are subject to conflicting standards that are most active in this style.
Effects of enriched environment on the expression of β-amyloid and transport-related proteins LRP1 and RAGE in chronic sleep-deprived mice
Authors: Yuan Ren , Yisen Zhang , Xiu Wang , Wei Tang , Wei Wang 
Published: September 2023

Abstract
Sleep plays an important role in the learning process and memory consolidation, and sleep deprivation (SD) leads to inadequate memory consolidation and plays an important role in brain development and plasticity. SD increases β-amyloid levels while impairing cognitive function. We explored the effect of enriched environment (EE) on β-amyloid and transporter protein LRP1 and receptor for advanced glycosylation end-products (RAGE) expression in chronic sleep deprived mice. We randomly divided mice into four groups (n = 10), the standard environment group (Ctrl group), the sleep deprivation group (SD group), the enriched environment intervention group (EE group), and the sleep deprivation plus environmental enrichment intervention group (SD + EE group). A modified multi-platform SD model was used to sleep deprive the mice for 19 h per day. Five hours of EE intervention was performed daily in the EE group and the SD + EE group, respectively. The behavioral measurements of mice were performed by Y-maze method and new object recognition; the expression levels of Aβ1-42, LRP1, and RAGE in prefrontal cortex and hippocampus of mice were measured by immunofluorescence; the expression levels of LRP1 and RAGE in prefrontal cortex and hippocampus were detected by Western blot. The results showed that EE could effectively ameliorate the effects of SD on cognitive impairment, reduce SD induced Aβ deposition, and decrease the expression of RAGE, while increase the expression of LRP1.
DEVELOPMENT OF TEACHING MATERIALS BASED ON CASE-BASED LEARNING ON STATISTICS
Authors: Fauzia Dewi Nur , Sobiruddin Dindin , Khairunnisa Khairunnisa 
Published: September 2023

This research is motivated by the limited use of mathematics teaching materials in schools. This research aims to develop teaching materials based on Case-Based Learning on Junior High School statistics in Grade VIII. This teaching material has systematically arranged using Case-Based Learning steps. The Teaching Materials were developed to consist of 3 learning activities: 1) Data Analysis, 2) Mean, Median, Mode, and 3) Range and Quartile. The research method used is the research and development method with the ADDIE (Analysis, Design, Development, Implementation, and Evaluation) development model. Teaching materials go through the validation and limited trial stage on five aspects: content feasibility, language, presentation, graphics, and Case-Based Learning. The results showed that the teaching materials developed have Very Valid criteria based on the Validator's assessment. It is getting a V Aiken coefficient of 0.8890, while the students' responses resulted in 82.33% on very feasible criteria. So we can conclude that the Case-Based Learning teaching materials on Statistics material are suitable to be used as a support for learning mathematics in schools.
PENGEMBANGAN BAHAN AJAR TRANSFORMASI GEOMETRI BERBANTUAN GEOGEBRA UNTUK MEMFASILITASI KEMAMPUAN VISUALISASI
Authors: Satriawati Gusni , Ridwan Muhammad , Kustiawati Dedek 
Published: September 2023

Tujuan Penelitian ini adalah: (1) Menghasilkan modul berbantuan Geogrebra dalam mamfasilitasi kemampuan visual peserta didik pada materi transformasi geometri, (2) Mengetahui tingkat kelayakan pada modul yang telah dikembangkan, (3) Mengetahui kemampuan visual peserta didik setelah menggunakan modul yang telah dikembangkan. Penelitian ini menggunakan metode Research and Development dengan model pengembangan ADDIE yang merupakan singkatan dari Analysis, Design, Development, Implementation, dan Evaluations. Produk yang dikembangkan berupa modul transformasi geometri berbantuan Geogebra kelas XI SMA/MA/SMK/MAK. Subjek uji coba dalam penelitian ini meliputi validator ahli yang terdiri atas 3 dosen pendidikan matematika UIN Syarif Hidayatullah Jakarta dan 3 guru Matematika MAN 16 Jakarta, serta subjek uji coba terbatas yang terdiri atas 35 peserta didik kelas XII IPA MAN 16 Jakarta. Instrumen yang digunakan dalam penelitian ini adalah lembar validasi ahli dan lembar angket respon peserta didik. Hasil penelitian ini menunjukkan bahwa bahan ajar yang dikembangkan memperoleh nilai V Aiken dari validator ahli sebesar 0,89 dengan kriteria sangat layak dan memperoleh respon baik dari peserta didik dengan nilai v aiken sebesar 0,80. Sedangkan untuk kemampuan visualisasi peserta didik memperoleh nilai rata-rata 78,80 di atas nilai KKM yang ditetapkan oleh sekolah yaitu 77. Dengan demikian, Modul Transformasi Geometri Berbantuan Geogebra Kelas XI SMA/MA/SMK/MAK dapat memfasilitasi kemampuan visualisasi peserta didik
PENGEMBANGAN LKPD DENGAN PENDEKATAN PMRI PADA MATERI OPERASI PERKALIAN ALJABAR MENGGUNAKAN KONTEKS COVID-19
Authors: Setiawan Ardi Yusuf , Arifin Sujinal , Wardani Ambarsari Kusuma 
Published: September 2023

This study aims to produce a worksheet with the PMRI approach on algebraic multiplication operations material using the context of covid 19 which is valid, practical, and effective. This type of research is research and development from Tessmer which focuses on two stages, namely the preliminary stage and the formative evaluation stage which consists of the expert review, one-to-one evaluation, small group, and field test stages. The subjects of this research were class VII students of SMP Negeri 35 Palembang. Data collection techniques used are interviews, questionnaires and tests. From the results of the study, the following conclusions were obtained: (1) The validity of Student Worksheets can be shown bythe validation results with the validators at the expert review stage with an average score result of 3,65 by three validators. (2) The practicality of Student Worksheets can be shown by the results of the student questionnaire at the one-to-one evaluation stage with an average practicality level of 3.56, the small group stage with an average practicality level of 3.47, and the field test stage with an average practicality level of 3.58. (3) The effectiveness of student worksheets can be shown by student learning outcomes in the form of post tests in the small group stage with an average level of effectiveness of 79.33 and also in the field test stage with an average level of effectiveness of 86.93.
Early Glycemic State and Outcomes of Neonates With Hypoxic-Ischemic Encephalopathy
Authors: Mietzsch Ulrike , Wood Thomas R. , Wu Tai-Wei , Natarajan Niranjana , Glass Hannah C. , Gonzalez Fernando F. , Mayock Dennis E. , Comstock Bryan A. , Heagerty Patrick J. , Juul Sunny E. , Wu Yvonne W. ,   HEAL Study Group
Published: September 2023

OBJECTIVES
In infants with hypoxic-ischemic encephalopathy (HIE), conflicting information on the association between early glucose homeostasis and outcome exists. We characterized glycemic profiles in the first 12 hours after birth and their association with death and neurodevelopmental impairment (NDI) in neonates with moderate or severe HIE undergoing therapeutic hypothermia.

METHODS
This post hoc analysis of the High-dose Erythropoietin for Asphyxia and Encephalopathy trial included n = 491 neonates who had blood glucose (BG) values recorded within 12 hours of birth. Newborns were categorized based on their most extreme BG value. BG &gt;200 mg/dL was defined as hyperglycemia, BG &lt;50 mg/dL as hypoglycemia, and 50 to 200 mg/dL as euglycemia. Primary outcome was defined as death or any NDI at 22 to 36 months. We calculated odds ratios for death or NDI adjusted for factors influencing glycemic state (aOR).

RESULTS
Euglycemia was more common in neonates with moderate compared with severe HIE (63.6% vs 36.6%; P &lt; .001). Although hypoglycemia occurred at similar rates in severe and moderate HIE (21.4% vs 19.5%; P = .67), hyperglycemia was more common in severe HIE (42.3% vs 16.9%; P &lt; .001). Compared with euglycemic neonates, both, hypo- and hyperglycemic neonates had an increased aOR (95% confidence interval) for death or NDI (2.62; 1.47–4.67 and 1.77; 1.03–3.03) compared to those with euglycemia. Hypoglycemic neonates had an increased aOR for both death (2.85; 1.09–7.43) and NDI (2.50; 1.09–7.43), whereas hyperglycemic neonates had increased aOR of 2.52 (1.10–5.77) for death, but not NDI.

CONCLUSIONS
Glycemic profile differs between neonates with moderate and severe HIE, and initial glycemic state is associated death or NDI at 22 to 36 months.
Species specifics of morphology of the liver of the fishes of the Cyprinidae family
Authors: Horalskyi L. P. , Demus N. V. , Sokulskyi I. M. , Gutyj B. V. , Kolesnik N. L. , Pavliuchenko O. V. , Horalska I. Y. 
Published: September 2023

Providing mankind with high-quality products of aquaculture is possible only by introduction of modern industrial technologies to fish farming, growing fish based on modern scientific achievements. Assessment of the ecotoxic situation and identification of impacts of various unfavourable factors of aquatic environment on aquatic organisms should be made through morphological studies of the organs that are first to encounter the impact. The study revealed species specifics of the morphology of the liver of the fishes of the Cyprinidae family – Prussian carp (Carassius gibelio), Eurasian carp (Cyprinus carpio), and bighead carp (Hypophthalmichthys nobilis), which vary by extent of the motor activity in the aquatic environment, nutrition, etc. We determined that during phylogenetic development of fish that grow in the aquatic environment, there occurs a certain restructuring of the liver: the adaptation to various living conditions were accompanied by changes in a number of parameters of macro- and microscopic architectonics of the liver. Cyprinus carpio and Carassius gibelio (omnivores) have a two-lobe liver, while Hypophthalmichthys nobilis (a herbivore) has a three-lobe liver. For C. carpio and H. nobilis, a characteristic feature of the liver was presence of the hepatopancreatitis (the liver and the pancreas, associated into a single organ), and in C. gibelio, they are differentiated into individual organs. A peculiarity of the microscopic structure of the liver of the Cyprinidae family is poorly developed interlobular connective tissue, and parenchyma of the liver lobule has a tubular structure as polyhedral, curved thick-walled tubules, the walls of which are hepatocytes. The greatest amounts of cytoplasm and karyoplasms were seen in C. gibelio, equaling respectively 12.98 ± 1.42 and 0.40 ± 0.02 µm³. The lowest volume of the indicated parameters was in C. carpio, particularly 2.97 ± 0.22 and 0.21 ± 0.01 µm³, respectively. The lowest nuclear-cytoplasmic ratio was observed in hepatocytes of C. gibelio (0.0316 ± 0.0024). The conducted morphological studies at the levels of organs, tissues and cells can reveal how the fishes’ bodies adapt to particular living conditions and impacts of environmental factors.
Literaturas del fin del mundo
Authors: Guizzo Antonio Rediver , Soalheiro Grade Maíra , Paez Florencia 
Published: September 2023

En este artículo, analizamos cómo O Deus das avencas (2021), de Daniel Galera, participa de un grupo de narrativas que convencionamos llamar literaturas del fin del mundo – caracterizadas por la composición de enredos distópicos o post apocalípticos que figuran la asunción de regímenes totalitarios al poder, la reducción de grupos económicamente desfavorecidos a la “vida desnuda”, el ahondamiento de la explotación de los recursos naturales y de las desigualdades sociales, la precarización del trabajo, la transformación de las tecnologías de comunicación en tecnologías de vigilancia, control y represión, y otros temores surgidos de las crisis democráticas y resurgimiento del capitalismo liberal. La obra O Deus das avencas (2021) está compuesta por tres cuentos que, aunque dispares, parecen constituir una gradación de las relaciones sociales y políticas del país hacia la ruptura de las formas de sociabilidad. El primer cuento, “O Deus das avencas”, presenta la agonía de una pareja que espera el nacimiento de su hijo ante la incertidumbre del rumbo político del país; la segunda, “Tokio”, narra una sociedad distópica en la que la severa devastación ambiental y la drástica reducción de las interacciones humanas se suman a la creencia en la posibilidad de trasladar la conciencia a dispositivos tecnológicos; la tercera, “Bugonia”, presenta un futuro postapocalíptico en el que la humanidad, en ausencia de tecnologías y bajo la amenaza de una patología contagiosa y letal, vuelve a formas tribales de sociabilidad y, para sobrevivir, establece una relación de mutualismo con abejas. En el análisis propuesto, dialogamos con investigadores que observan el crecimiento de la producción distópica en diferentes países y contextos sociopolíticos, como María Laura Pérez Gras (2017), Eirik Vassenden (2022), Tom Moylan (2018), Jill Lepore ( 2017), Gregory Claeys (2017), entre otros.
Los Borges de Borges: la construcción de una alteridad particular
Authors: Calderón Sánchez Estefanía 
Published: September 2023

La obra del argentino Jorge Luis Borges marcó un hito dentro de la historia literaria, dado que cuestionó muchos de los preceptos heredados de la tradición europea al formular una poética donde la ambigüedad, lo paródico y la inestabilidad son partes intrínsecas de su perspectiva literaria. Por ello, este artículo se centrará en uno de los temas más recurrentes del argentino: la alteridad, el cual permite no solo hablar de una construcción literaria particular, sino también acercarse a la figura de un escritor que se desdobla y se revela en sus textos. Así, los textos por analizar forman parte de dos de las producciones más importantes del argentino. Por un lado, “Los teólogos” y “La busca de Averroes” pertenecen al libro El Aleph (1949) y, por otro, “El otro” es uno de los cuentos de El Libro de Arena (1975). Los tres han sido bastante citados por la crítica literaria; sin embargo, no se encontró ningún estudio donde se estableciera un diálogo entre ellos. Por ende, el presente análisis busca construir una perspectiva que permita enriquecer la discusión sobre la alteridad y su relación con los temas del doble y de la identidad dentro del mundo borgeano.
POLYETHYLENE GAS PIPELINES: PROBLEMS AND EXPERIENCE OF TECHNICAL DIAGNOSTICS
Authors: Martynenko S.N. , Zakharov V.V. 
Published: September 2023

More and more often in various industries, polymer materials are replacing metal structures. The gas industry is no exception, one of the areas of development of which was the introduction of polyethylene pipes to replace traditional steel pipes. This process began more than half a century ago, and according to data at the beginning of 2023, polyethylene pipes account for about 49.5 % of the length of all underground gas pipelines of gas distribution networks.
The main obvious advantage of polyethylene pipes over steel pipes is corrosion resistance, which allows them to be operated without the use of protective anticorrosive coatings and electrochemical protection means. The strength properties of polyethylene pipes allow their operation at gas pressure up to 1.2 MPa, which makes it possible to almost fully meet the needs of the gas distribution sphere. The welding technologies of polyethylene pipes are well developed, standardized and automated.
An important problem for long-term operating polyethylene gas pipelines is the assessment of their technical condition and determination of the residual life. Despite the existing need for work of this kind (for example, in 2022 only in the territory of the Saratov region it was required to carry out technical diagnostics of 8 gas pipelines with a total length of 39.86 km), expert organizations do not have the necessary tool for implementing this task today. Although the mechanism of aging of polyethylene is well known, there are no generally accepted standards for assessing the performance of polyethylene gas pipelines based on a comprehensive accounting of the influence of aging factors that determine their technical condition.
The purpose of this article is to highlight the experience of Giproniigaz JSC in technical diagnostics of polyethylene gas pipelines, as well as to draw the attention of specialists from both the gas industry and academic science to the problem of developing a methodology for technical diagnostics of polyethylene gas pipelines.
ABOUT THE FILLING FACTOR OF PROGRESSIVE CAVITY PUMPS
Authors: Baldenko F.D. , Kovalevskiy S.A. 
Published: September 2023

Progressive Cavity Pumps (PCP) are becoming more and more common in various industries. In the oil and gas sector, PCP are widely used in downhole pumping units for oil production, as well as multiphase pumps for transporting gas-liquid mixtures. In recent decades, PCP have been widely used in the drilling mud circulation systems in fine cleaning units using centrifuges, as well as in various environmental projects. At the same time, industrial experience shows that in order to increase the efficiency of the PCP in various technological processes in the oil, construction, food and other industries, it is necessary to clarify some provisions of the theory and practice of using single-screw hydraulic machines in nonstandard operating conditions. One of these issues, which has not yet been fully reflected in scientific and reference publications, is the study of the process of filling screw working cavities in the case of pumping high-viscosity fluids.
The article discusses the theoretical foundations of modeling the process of filling the PCP and proposes dependencies for determining the filling factor, which allows for a reasonable approach to the choice of geometric and operational parameters of the pump in a wide range of changes in the properties of pumped products.