bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotional Experience, Physiological Reactivity, and Psychological Difficulties during middle childhood: a pilot study
Authors: Charpentier-Mora S. , Tironi M. , Bizzi F. 
Published: August 2023

Introduction
Many studies linked expression and regulation of emotions as transdiagnostic variables involved in the emergence of psychopathological disorders. However, few studies investigated such processes during middle childhood, a critical period of life defined by significant psychological, physical, and social changes.ObjectivesExplore the relationship between child’s emotion regulation – both emotional subjective experience and physiological reactivity – and child’s psychological difficulties.Methods
20 children (Mage=10.7, SD=1.25; 65% males) and their mothers were recruited from general population. Emotion regulation was assessed with (1) How I Feel (HIF) and Positive and Negative Affect questionnaires (PANAS) and (2) Heart Rate (i.e., Beats Per Minute, BPM) and Heart Rate Variability (i.e., High Frequency and Low Frequency ratio, LF/HF). Child’s psychological difficulties were measured with the parent report Child Behavioral Checklist 6-18 (CBCL-6/18).ResultsStatistically significant correlations emerged between the HIF-Positive emotions scale and both externalizing (rs = -.51) and internalizing (rs = -.46) difficulties; the HIF-Negative emotions scale and internalizing difficulties (rs = .49); LF/HF and internalizing difficulties (rs = -.58). Finally, a non-significant but moderate effect was found between the HIF-Negative emotions scale and externalizing difficulties (rs = .33).Conclusions
Although the limited number of participants, data suggest an interesting role played by both child’s emotional experience and physiological reactivity on internalizing and externalizing difficulties as reported by mothers. More specifically, child’s experience of positive emotions is associated with fewer internalizing and externalizing difficulties, while child’s experience of negative emotions illustrates an opposite relationship, implying the relevance of looking at child’s emotional subjective experience in understanding psychological difficulties. Moreover, LF/HF ratio – labeled as the child’s sympathovagal balance – seems like it might be higher in children with less internalizing difficulties. Although doubts about LF/HF interpretation, several studies share this view showing a decrease in autonomic reactivity in internalizing problems, such as depression, in adults. Overall, our preliminary results underline the importance of studying the emergence of psychopathological outcomes in middle childhood connected to both psychological and physiological emotional processes.Disclosure of InterestNone Declared
Psychological impact of motor impairment in tow forms of congenital muscular dystrophy
Authors: Boujelbene I. , Chaabane M. , Guirat M. , Ben Touhemi D. , Gharbi N. , Yousr M. , Kamoun H. , Ben Ayed I. 
Published: August 2023

IntroductionCongenital muscular dystrophies (CMDs) represent a heterogeneous group of early-onset muscle disorders presenting primarily with hypotonia and delayed motor development. Several genes are known to be responsible for CMDs, including the LAMA2 gene, involved in merosin-deficient type 1A (MDC1A), and the FKRP gene involved in muscular dystrophy-dystroglycanopathy type B5 (MDDGB5). These two forms of CMD are autosomal recessive and are each characterized by the presence of a mutation with a founder effect in South Tunisia. Cognitive development associated with the founder mutation in the LAMA2 gene (c.8007delT) is often conserved, whereas in the founder mutation of the FKRP gene (c.1364 C>A), motor impairment is associated with intellectual disability (ID).ObjectivesTo compare the psychological impact of motor impairment in children presenting these two forms of CMD and their families.MethodsThe study consisted of a survey of parents of children with a confirmed diagnosis of MDC1A (5 from 3 unrelated families) or MDDGB5 (3 from 3 unrelated families). The correspondent founder mutation was already identified in the homozygous state by targeted sequencing. Participants’ parents completed the Parent Strengths and Difficulties Questionnaire (SDQ), a behavioral screening tool designed for children aged from 2 to 17 years. The SDQ assesses emotional symptoms, behavior problems, hyperactivity, and peer relationships; The SDQ Impact Supplement assesses the impact of all these children’s difficulties on their families.ResultsThe average age of the children was 4.95±3.92 with two children who were not assessable by the SDQ (age< 2 years). Unlike children with MDC1A, ID has been reported in all children with MDDGB5. The mean SDQ total score for children with MDC1A was 11, whereas the mean score for children with MDDGB5 was 14.875, reflecting greater difficulty for children with MDDGB5. The family impact score was higher in families with children with MDDGB5 than in children with MDC1A (10,5 vs 7), which may be due to the burden of management of the ID associated with the motor impairment. The more pronounced difficulties associated with MDDGB5 are likely to be related to the associated ID. Whereas in MDC1A, the difficulties observed are related to the direct impact of the motor impairment. The presence of cognitive disorders associated with a motor deficit aggravates behavioral adaptation and makes the management of these children more difficult.ConclusionsIn the absence of a comparable study in the literature, the present is conducting future studies on the behavioral profile of children with CMD to obtain a better understanding of their difficulties in everyday life and to develop interventions adapted to their familiesDisclosure of InterestNone Declared
Possible psychotic episode after repeated ayahuasca intake: a case report
Authors: Prades Marin E. , Martínez Torres A. , Sánchez Díez P. 
Published: August 2023

IntroductionAyahuasca is a traditional brew containing the psychedelic 5-DMT (a tryptamine that acts as a 5HT2A-R agonist) used to achieve non-ordinary states of consciousness, with a long tradition among various cultures in ritual and therapeutic contexts. Ayahuasca is being studied as potential treatment in Mental Health, which has led to non-controlled and recreational use. This has led to a rise in the description of side effects, such as substance-induced psychosis.ObjectivesTo describe a case of a possible psychotic episode related to the intake of ayahuasca brew in a ritual context.MethodsClinical assesment and bibliographic review of pertinent literature.ResultsWe will present the case of a 43 year old woman, who participated in three ayahuasca sessions in three consecutive months. Two days after the last session, she suffered and episode of loss of consciousness, convulsions, loss of streng and paraesthesia in right forearm and righr side of the face and head; and apparition of perceptual alterations and delusions that she did not experience during the trip. Such alterations included the perception of electromagnetic fields (EMF) robbing her of her vital energy and lifeforce. She required ICU treatment for four days, after which se was hospitalized in Internal Medicine Unit and was assessed by Mental Health team. Though the symptoms were coherent with the previous beliefs of the patient, they were clearly exacerbated and interfered with her normal and previous functioning. She was treated with risperidone 1,5 mg, with complete symptom remission.ConclusionsThe case presented is consistent with other reports of ayahuasca-induced psychotic symptoms, though with less intensity and duration. We discuss prevalence and repercussions of the rising use of this powerful substance; that must be taken into consideration by clinicians worldwide.Disclosure of InterestNone Declared
Cannabis use during first episode psychosis in Tunisia
Authors: Bergaoui E. , Lansari R. , Chehaider O. , Moalla M. , Larnaout A. , Melki W. 
Published: August 2023

IntroductionCannabis use is frequent among patients with psychotic disorders. However, the relationship between cannabis consumption and transition to psychosis has not been fully elucidated.ObjectivesThe aim of this study was to assess the prevalence of cannabis use in first episode psychosis and its correlation with transistion to psychosis and severity of symptoms.MethodsA cross-sectional study was conducted at the psychiatric department D of Razi hospital including 50 patients hospitalized for first episode psychosis. The evaluation focused on sociodemographic and clinical characteristics of the patients. We used the cannabis abuse screening test (CAST) and positive and negative syndrome scale (PANSS).ResultsThe sex ratio of our patients was 4 men per 1 woman. The mean age was 25.6±6.16 years. Two-thirds of the patients had secondary education (n=24). Half of them had no occupation (n=17). Twenty-five patients (71%) had no psychiatric history. The total PANSS score showed a mean of 58.29±12.90 with extremes between 35 and 91. About 60% of the patients used cannabis with high addiction risk in 81% of cases. The mean duration of cannabis use was 7,04 years, 3 times a week. Cannabis use was correlated to the gender. However, no correlation was found between cannabis use and duration of untreated psychosis niether the negative or positive symptoms.ConclusionsAlthough cannabis use is knownto accelerate transition to psychosis, it does not affect the severity of symptoms. Further work is necessary to identify the factors that underlie individual vulnerability to cannabinoid-related psychosis and to elucidate the biological mechanisms underlying this risk.Disclosure of InterestNone Declared
Neuroradiological manifestations of drug use: description of clinical cases
Authors: Faria I. , Silva T. 
Published: August 2023

IntroductionDrug use and misuse continue to create public health challenges in the world, leading to overdose deaths, infections, and other chronic health conditions. Illegal addictive drugs can lead to functional or structural impairment of the central nervous system (CNS). Because clinical findings alone are often nonspecific, and some patients are unlikely to admit substance abuse, the neuroimaging may play an important role in establishing the diagnosis and initiating treatment.ObjectivesWe aim to provide an overview of the structural imaging findings on computed tomography (CT), magnetic resonance (MR) imaging related to chronic and acute abuse of commonly addictive substances, including cannabis, alcohol, cocaine, and opioids.MethodsNon systematic review of the literature on the subject and description of three clinical cases.ResultsPathomecanisms of drugs misuse include excitotoxicity, which may lead to an acute or subacute leukoencephalopathy, and vascular complications, including vasoconstriction, vasculitis, or hypertension, which may lead to intracranial hemorrhage or ischemia. Alcohol abuse may lead to Wernicke-Korsakoff syndrome, revealing in MR bilateral symmetrical hyperintense signals on T2-weighted; Marchiafava-Bignami disease (MBD) is a very rare condition which may present hypodense lesions in the corpus callosum; and alcoholic cerebellar degeneration is a common type of acquired cerebellar ataxia and may present cerebellar volume loss localized to the anterior superior vermis. One of our clinical cases is a female, 39 years, and present cocaine induced multifocal leukoencephalopathy, associated with inflammatory/immune mediated mechanism. Other clinical case (female, 24 years) demonstrate spongiform leukoencephalotpathy from “chasing” heroin, with a characteristic presentation.ConclusionsThe main pathomechanisms related to the abuse of drugs are ischemia, hemorrhage, and leukoencephalopathy related to excitotoxicity of the drug or its derivatives. Clinical findings are nonspecific, highlighting the need to recognize these complications at both CT and MR imaging. Therefore, diagnostic imaging modalities can play a pivotal role in the recognition and timely management of drug-related complications in the CNS.Disclosure of InterestNone Declared
Exploring the concept and management of post ictal psychosis through a clinical case and review
Authors: Compaired Sánchez A. , Lázaro Alonso B. , Gómez-Arnau Ramírez J. 
Published: August 2023

IntroductionPostictal Psychosis of Epilepsy (PIPE), part of the group collectively known as Psychosis of Epilepsy, is characterized by an onset of confusion or psychotic symptoms within one week of apparent normal mental function. PIPE has been argued to be underdiagnosed in the clinical population, perhaps due to a failure to recognize the temporal relation between the seizure and the psychotic episode.ObjectivesTo explore the concept and management of post ictal psychosis.MethodsWe present a clinical case and a review of the literature concerning post ictal psychosis.Results
We report the case of a 36 year old woman with focal refractory epilepsy after a likely episode of limbic encephalitis in 2015. Cognitive and psychiatric sequelae in the form of depressive symptoms, in treatment with neurology and psychiatry since 2021. One previous episode of psychotic symptoms during seizures. Worsening of seizure frequency since march of 2022 with apparent normalization (absence of seizures after dose reduction of eslicarbamazepine and introduction oflamotrigine) for about four days before being hospitalized in the neurology unit due tobehavioral abnormalities. During psychiatric exploration, the patient showed signs of partial clouding of consciousness with manierisms, ecopraxias and ecolalias; verbigerance in the form of the neurologist’s name and bizarre movements like looking behind suggestive of sensoroperceptive disturbances. The symptomatology resolved itself during the following week after treatment with diazepam.Finally, a narrative review concerning the case was also performed; with particular emphasis on antipsychotic drugs with low risk of lowering seizure threshold (such as risperidone or aripiprazole) as the recommended treatment.ConclusionsOur findings point to the relevance of Postictal Psychosis of Epilepsy as a clinical entity. Further studies on pathogenic mechanisms and therapeutic management are required.Disclosure of InterestNone Declared
Analysis of the implementation of the collaboration programme between the headache unit and the liaison psychiatry programme
Authors: Garcia Lazaro F. , Gotor Sanchez Luengo F. , Garcia Ligero del Rincon E. , Luque Budia A. 
Published: August 2023

Introduction
Headache is associated with a wide spectrum of comorbid, statistically and biologically related pathological processes. A person with headache is more likely to have a psychological disorder than the rest of the general population, even more so if the headache is chronic. Psychiatric comorbidity has been shown to act as a risk factor in the chronification of headache and may contribute to increased disability. Anxiety and mood disorders are the psychiatric comorbidities that most influence aspects of the disease such as prognosis, response to treatment and even quality of life.ObjectivesTo analyse the results of the implementation of a joint consultation between the headache unit and the liaison psychiatry programme.To evaluate the efficacy of interdisciplinary intervention in patients diagnosed with resistant headache.Methods
We performed a descriptive analysis of the database of patients included in the headache programme including data on neurological diagnosis, psychiatric diagnosis, type of intervention, referral to psychiatric consultation and number of subsequent revisions.ResultsDiagnoses related to anxious and depressive symptomatology are the most common diagnoses in patients diagnosed with treatment-resistant headache.In most of the patients analysed in the database a single joint intervention was necessary.Referral to mental health consultations from the programme did not lead to an increase in urgent demands with a clinical correlation in terms of diagnostic orientationConclusionsJoint intervention in the management of these patients has been found to be beneficial in the reinterpretation of symptoms and progressive desensitisation to fear of chronic illness.Training in symptom detection at the psychopathological level is important for professionals from other areas as well as training in interviewing skills.More studies are needed to analyse the outcome of joint interventions in patients with difficult-to-manage chronic diseases and their comorbidities.Disclosure of InterestNone Declared
Personalisation of the management of schizophrenia and other primary psychoses
Authors: Galderisi S. 
Published: August 2023

AbstractIn the treatment of persons with schizophrenia the goal has gradually shifted from the reduction of symptoms and prevention of relapse to recovery. However, this goal is achieved for a minority of persons with schizophrenia, while for most of them the disorder still is a major cause of disability, poor quality of life and premature death, and presents considerable social and economic costs.Studies aimed at identifying variables with a significant impact on schizophrenia outcome indicate that early intervention, shared decision making, treatment continuity, physical comorbidities, negative symptoms, deficits in cognitive functions and functional capacity account for most of the functional impairment of patients but are often neglected in current clinical practice.In this presentation, I will illustrate the role of these variables and the need for an in-depth clinical characterization of persons with primary psychoses to implement personalized treatment plans and improve the care of people with schizophrenia.Disclosure of InterestNone Declared
Adjustment strategies adopted by higher education students during COVID-19 pandemic: focus group discussions
Authors: Laranjeira C. , Dixe M. , Charepe Z. , Querido A. 
Published: August 2023

IntroductionWith the closure of higher education institutions during the COVID-19 sanitary crisis, students have experienced problems such as interruptions to their education, loss of peer support networks, and mental health issues.ObjectivesThis study aimed to explore adjustment patterns used by students to overcome the impact of the COVID-19 pandemic.MethodsA qualitative descriptive study was developed by carrying out Focus Group Discussions (FGDs). Portuguese students enrolled in education levels above high school, including undergraduate and graduate programs, were considered eligible. Participants were recruited using convenience sampling. Each FGD took approximately 60–90 min.Results
Twelve students were participated in 2 FGDs, each one with 6 participants. Mostly were undergraduate students (Bachelor’s degree), in the field of health area. The thematic analysis revealed three main themes. The first theme was related to the personal sphere and included most of adjustment strategies used, namely: pandemic as a “window of opportunity” to be involved in new academic and professional projects; work-life balance by organizing and separating work from private life; self-care through the adoption of healthy lifestyles; being compassionate with others and compliance with sanitary measures. In the social sphere, students evoked new ways of communicating via digital networking to compensate for the lack of physical proximity and stay in safe contact with friends and relatives. In the contextual sphere, students talked about the importance of adapting the “teaching/learning” environment. Tailored teaching support was a significant strategy, especially in maintaining their motivation.ConclusionsSeveral strategies were pointed by students to stay mentally healthy and mitigate delayed-onset post-traumatic stress disorder during the COVID-19 pandemic. Besides, positive coping and hope should be integrated into the standard training of students across all study areas.Disclosure of InterestNone Declared
SUICIDE AND COVID-19: A TEMPORAL-SPATIAL ANALYSIS IN THE STATE OF PARANÁ AND THE 15th HEALTH REGIONAL FROM 2010 TO 2020
Authors: Silva K. , Bettoni C. , Santos R. , Schoeler N. , Porcu M. 
Published: August 2023

IntroductionSuicide occurs throughout all the life course, but in 2019 it was the fourth leading cause of death among 15-29 years old worldwide.In Brazil, between 2010 and 2019, 112,230 deaths from suicide were recorded, with a 43% increase in the annual number of deaths from the beginning to the end of that period in all age groups. (SAÚDE, 2021).ObjectivesTo accomplish a space-time analysis of the rate of suicide deaths in the state of Paraná and in its 15th Health Regional, from 2010 to 2020, in the population aged 20 to 69 years, contrasting the pre-pandemic periods (2010 to 2019) and during the COVID-19 pandemic (2020).MethodsThis is an ecological, observational, cross-sectional, retrospective study, using spatial and temporal analysis tools, based on secondary data obtained from the Department of Informatics of the Unified Health System (DATASUS), in the period 2010 and 2020, referring to the 5568 Brazilian cities, with emphasis on the 399 of the state of Paraná and the 30 cities of its 15th Health Regional (HR).Exploratory Spatial Data Analysis (AEDE) techniques were used through GeoDA (version 1.20.0.8) and QGis (version 3.22.4) software to determine the existence of Spatial Autocorrelation (Moran’s Global Index or Moran I) and to calculation and visualization of the Local Spatial Association Indicator (LISA).Global (Moran I) and local (LISA) spatial autocorrelation coefficients were considered significant when p < 0.05 at a 95% confidence level.The Space Time Cube is a simultaneous spatial and temporal analysis methodology of ArcGIS Pro Software (ESRI, 2011) that evaluates the behavior of a value in space over a defined time interval.ResultsThe arithmetic mean of the age at death by suicide, from 2010 to 2020, was 41.1 years, with a standard deviation of 13.3 years and a median of 40 years. Most deaths in the pre-pandemic period occurred among men aged 20 to 29, followed by women aged 30 to 39 years and men aged 40 to 49 years.Regarding the most common causes and modes of suicide in the State, there was no significant difference between the periods from 2010 to 2019, pre-pandemic reference, and 2020 (pandemic) in a global perspective. The three main causes of death were: 1) Hanging, strangulation or suffocation (ICD-10 X70, T71) were the majority and accounted for more than half of all causes; 2) Self-harm by gunshot (ICD- 10 X74 and X72); 3) Self-poisoning by pesticides and drugs, respectively (ICD-10 X68 and X61).ConclusionsThis study showed an increase in suicide deaths in the state of Paraná, when analyzing the periods before and during the COVID-19 pandemic. The most affected population was men, aged 20 to 29 years.Disclosure of InterestNone Declared