bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on safety assessment methods of gravity anchors based on a simplified mechanical model
Authors: Li Hongru , Yang Min , Yin Xiaotao 
Published: May 2023

Gravity anchor blocks are a common type of ground anchor used for suspension bridges, whose bearing depends on its large body and gravity. As there is no stratum requirement, the safety of the anchor block is important for bridge stability. This study summarizes all available estimation indexes, calculating methods, and evaluation criteria for gravity anchor block safety for the Ruili bank of the Banjin Dam grand suspension bridge. The anti-overturning, anti-sliding, base stress, and deformation safeties were comprehensively evaluated using methods including the suggested specification method (SM), simplified mechanical method (SMM), and finite element method (FEM), the results of which were compared and analyzed. The reasons for errors and improved formulas and working conditions were presented. The main conclusions were as follows. 1) The methods for calculating different evaluation indexes according to specifications lack consistency. Moreover, FEM requires that designers have good computer skills and has low feasibility in practice. 2) The SMM for gravity anchor block safety estimation as described in this study, whose indexes cover systematic and overall, the computational formula is simple and speedy, with relatively conservative results and good practicability. 3) SM, SMM, and FEM were all used for the safety estimation of gravity anchor blocks in Ruili bank. The anti-overturning and anti-sliding stability coefficients must all meet the specification requirements of 2.0. SM cannot be used to estimate the base tensile stress under limited conditions. SMM denoted tensile stress at 2.5 times the main cable design force, compared to 3.2 P for FEM. Deformation calculation methods are not given by SM, but can be suggested by SMM based on the elastic mechanics. The horizontal displacements under design load conditions were 122 mm (SMM), 108 mm (FEM), and 44 mm (composite foundation treated by root piles), with a safety standard of &lt;80 mm. The vertical displacements were 338 mm (SMM), 110 mm (FEM), and 123 mm (composite foundation treated by root piles), with a safety standard of &lt;160 mm. These findings proved the feasibility of SMM for the safety design of gravity anchor blocks in cases lacking regional experience.
Attrition in the Gothenburg H70 birth cohort studies, an 18-year follow-up of the 1930 cohort
Authors: Rydén Lina , Wetterberg Hanna , Ahlner Felicia , Falk Erhag Hanna , Gudmundsson Pia , Guo Xinxin , Joas Erik , Johansson Lena , Kern Silke , Mellqvist Fässberg Madeleine , Najar Jenna , Ribbe Mats , Rydberg Sterner Therese , Sacuiu Simona , Samuelsson Jessica , Sigström Robert , Skoog Johan , Waern Margda , Zettergren Anna , Skoog Ingmar 
Published: May 2023

BackgroundLongitudinal studies are essential to understand the ageing process, and risk factors and consequences for disorders, but attrition may cause selection bias and impact generalizability. We describe the 1930 cohort of the Gothenburg H70 Birth Cohort Studies, followed from age 70 to 88, and compare baseline characteristics for those who continue participation with those who die, refuse, and drop out for any reason during follow-up.MethodsA population-based sample born 1930 was examined with comprehensive assessments at age 70 (N = 524). The sample was followed up and extended to increase sample size at age 75 (N = 767). Subsequent follow-ups were conducted at ages 79, 85, and 88. Logistic regression was used to analyze baseline characteristics in relation to participation status at follow-up.ResultsRefusal to participate in subsequent examinations was related to lower educational level, higher blood pressure, and lower scores on cognitive tests. Both attrition due to death and total attrition were associated with male sex, lower educational level, smoking, ADL dependency, several diseases, poorer lung function, slower gait speed, lower scores on cognitive tests, depressive symptoms, and a larger number of medications. Attrition due to death was also associated with not having a partner.ConclusionsIt is important to consider different types of attrition when interpreting results from longitudinal studies, as representativeness and results may be differently affected by different types of attrition. Besides reducing barriers to participation, methods such as imputation and weighted analyses can be used to handle selection bias.
Genetic diversity and genome-scale population structure of wild Indian major carp, Labeo catla (Hamilton, 1822), revealed by genotyping-by-sequencing
Authors: Sahoo Bismay , Das Gargee , Nandanpawar Priyanka , Priyadarshini Nirjharini , Sahoo Lakshman , Meher Prem Kumar , Udit Uday Kumar , Sundaray Jitendra Kumar , Das Paramananda 
Published: May 2023

Labeo catla (catla) is the second most commercially important and widely cultured Indian major carp (IMC). It is indigenous to the Indo-Gangetic riverine system of India and the rivers of Bangladesh, Nepal, Myanmar, and Pakistan. Despite the availability of substantial genomic resources in this important species, detailed information on the genome-scale population structure using SNP markers is yet to be reported. In the present study, the identification of genome-wide single nucleotide polymorphisms (SNPs) and population genomics of catla was undertaken by re-sequencing six catla populations of riverine origin from distinct geographical regions. DNA isolated from 100 samples was used to perform genotyping-by-sequencing (GBS). A published catla genome with 95% genome coverage was used as the reference for mapping reads using BWA software. From a total of 472 million paired-end (150 × 2 bp) raw reads generated in this study, we identified 10,485 high-quality polymorphic SNPs using the STACKS pipeline. Expected heterozygosity (He) across the populations ranged from 0.162 to 0.20, whereas observed heterozygosity (Ho) ranged between 0.053 and 0.06. The nucleotide diversity (π) was the lowest (0.168) in the Ganga population. The within-population variation was found to be higher (95.32%) than the among-population (4.68%) variation. However, genetic differentiation was observed to be low to moderate, with Fst values ranging from 0.020 to 0.084, and the highest between Brahmani and Krishna populations. Bayesian and multivariate techniques were used to further evaluate the population structure and supposed ancestry in the studied populations using the structure and discriminant analysis of principal components (DAPC), respectively. Both analyses revealed the existence of two separate genomic clusters. The maximum number of private alleles was observed in the Ganga population. The findings of this study will contribute to a deeper understanding of the population structure and genetic diversity of wild populations of catla for future research in fish population genomics.
Real-life impact of highly effective CFTR modulator therapy in children with cystic fibrosis
Authors: Olivier Margarete , Kavvalou Alexandra , Welsner Matthias , Hirtz Raphael , Straßburg Svenja , Sutharsan Sivagurunathan , Stehling Florian , Steindor Mathis 
Published: May 2023

Introduction: Recently, cystic fibrosis transmembrane regulator modulator therapy with elexacaftor/tezacaftor/ivacaftor has become available for children with cystic fibrosis (CF) carrying at least one F508del mutation.Objective: To assess the intermediate term effects of elexacaftor/tezacaftor/ivacaftor in children with cystic fibrosis in a real-world setting.Methods: We performed a retrospective analysis of records of children with cystic fibrosis, who started elexacaftor/tezacaftor/ivacaftor between 8/2020 and 10/2022. Pulmonary function tests, nutritional status, sweat chloride and laboratory data were assessed before, 3 and 6 months after the start of elexacaftor/tezacaftor/ivacaftor respectively.Results: Elexacaftor/tezacaftor/ivacaftor was started in 22 children 6–11 years and in 24 children 12–17 years. Twenty-seven (59%) patients were homozygous for F508del (F/F) and 23 (50%) patients were transitioned from ivacaftor/lumacaftor (IVA/LUM) or tezacaftor/ivacaftor (TEZ/IVA) to elexacaftor/tezacaftor/ivacaftor. Overall, mean sweat chloride concentration decreased by 59.3 mmol/L (95% confidence interval: −65.0 to −53.7 mmol/L, p &lt; 0.0001) under elexacaftor/tezacaftor/ivacaftor. Sweat chloride concentration also decreased significantly after transition from IVA/LUM or TEZ/IVA to elexacaftor/tezacaftor/ivacaftor (−47.8 mmol/l; 95% confidence interval: −57.6 to −37.8 mmol/l, n = 14, p &lt; 0.0001). Sweat chloride reduction was more marked in children with the F/F than in those with the F/MF genotype (69.4 vs 45.9 mmol/L, p &lt; 0.0001). At 3 months follow-up, body-mass-index-z-score increased by 0.31 (95% CI, 0.2–0.42, p &lt; 0.0001) with no further increase at 6 months. BMI-for-age-z-score was more markedly improved in the older group. Overall pulmonary function (percent predicted FEV1) at 3 months follow-up increased by 11.4% (95% CI: 8.0–14.9, p &lt; 0.0001) with no further significant change after 6 months. No significant differences were noted between the age groups. Children with the F/MF genotype had a greater benefit regarding nutritional status and pulmonary function tests than those with the F/F genotype. Adverse events led to elexacaftor/tezacaftor/ivacaftor dose reduction in three cases and a temporary interruption of therapy in four cases.Conclusion: In a real-world setting, elexacaftor/tezacaftor/ivacaftor therapy had beneficial clinical effects and a good safety profile in eligible children with cystic fibrosis comparable to previously published data from controlled clinical trials. The positive impact on pulmonary function tests and nutritional status seen after 3 months of elexacaftor/tezacaftor/ivacaftor therapy was sustained at 6 months follow-up.
Effects of phenylcapsaicin on aerobic capacity and physiological parameters in active young males: a randomized, triple-blinded, placebo-controlled, crossover trial
Authors: Jiménez-Martínez Pablo , Alix-Fages Carlos , Janicijevic Danica , Miras-Moreno Sergio , Chacón-Ventura Sara , Martín-Olmedo Juan J. , De La Cruz-Márquez Juan Carlos , Osuna-Prieto Francisco J. , Jurado-Fasoli Lucas , Amaro-Gahete Francisco J. , García-Ramos Amador , Colado Juan C. 
Published: May 2023

Objective: Phenylcapsaicin (PC) is a new capsaicin analog which has exhibited a higher bioavailability. This sudy assessed the effects of a low dose (LD) of 0.625 mg and a high dose (HD) of 2.5 mg of PC on aerobic capacity, substrate oxidation, energy metabolism and exercise physiological variables in young males.Materials and methods: Seventeen active males (age = 24.7 ± 6.0 years) enrolled to this randomized, triple-blinded, placebo-controlled, crossover trial. Participants attended the laboratory on 4 sessions separated by 72–96 h. A submaximal exercise test [to determine maximal fat oxidation (MFO) and the intensity at MFO (FATmax)] followed by a maximal incremental test (to determine VO2max) were performed in a preliminary session. The subsequent sessions only differed in the supplement ingested [LD, HD or placebo (PLA)] and consisted of a steady-state test (60 min at FATmax) followed by a maximal incremental test. Energy metabolism, substrate oxidation, heart rate, general (gRPE) and quadriceps (RPEquad) rate of perceived exertion, skin temperature and thermal perception were tested.Results: Clavicle thermal perception was lower in HD compared to PLA and LD (p = 0.04) across time. HD reduced maximum heart rate in comparison to PLA and LD (p = 0.03). LD reported higher general RPE (RPEg) values during the steady-state test compared to PLA and HD across time (p = 0.02). HD and LD elicited higher peak of fat oxidation during the steady-state test compared with PLA (p = 0.05). Intra-test analyses revealed significant differences for fat oxidation (FATox) in favor of HD and LD compared to PLA (p = 0.002 and 0.002, respectively), and for carbohydrate oxidation (CHOox) (p = 0.05) and respiratory exchange ratio (RER) (p = 0.03) for PLA. In the incremental test, only general RPE at 60% of the maximal intensity (W) differed favoring HD (p ≤ 0.05).Conclusion: Therefore, PC may contribute to increase aerobic capacity through the improvement of fat oxidation, maximum heart rate and perceptual responses during exercise.
Mental health state and its determinants in German university students across the COVID-19 pandemic: findings from three repeated cross-sectional surveys between 2019 and 2021
Authors: Tsiouris Angeliki , Werner Antonia M. , Tibubos Ana N. , Mülder Lina M. , Reichel Jennifer L. , Heller Sebastian , Schäfer Markus , Schwab Lisa , Rigotti Thomas , Stark Birgit , Dietz Pavel , Beutel Manfred E. 
Published: May 2023

BackgroundStudents were at an increased risk for elevated mental symptoms during the first year of the COVID-19 pandemic compared to pre-pandemic levels. As universities remained closed much longer than anticipated, the mental burden was expected to persist through the second year of the pandemic. The current study aimed to investigate the prevalence of mental distress from 2019 through 2021 and identify risk factors for elevated mental burden, focusing on gender.MethodsWe analyzed three cross-sectional online surveys among students at the University of Mainz, conducted in 2019 (n = 4,351), 2020 (n = 3,066), and 2021 (n = 1,438). Changes in the prevalence of depressive symptoms, anxiety, suicidal ideation, and loneliness were calculated using Pearson's chi-square tests and analyses of variance. Multiple linear regressions yielded associated risk factors.ResultsThe proportion of students with clinically relevant depressive symptoms was significantly higher during the pandemic (38.9% in 2020, and 40.7% in 2021), compared to pre-pandemic (29.0% in 2019). Similarly, more students reported suicidal ideation and generalized anxiety during the pandemic with a peak in the second pandemic year (2021). The level of loneliness was significantly higher in 2020, compared to 2019, and remained at a high level in 2021 (p &lt; 0.001, ηp2 = 0.142). Female and diverse/open gender, being single, living alone, and being a first-year student were identified as risk factors associated with mental burden during the pandemic.DiscussionMental burdens remained elevated among students through the second year of the pandemic and were associated with socio-demographic risk factors and pandemic-related concerns. Future research should monitor recovery and evaluate the need for psychosocial support.
Evaluasi Media Sosial Sebagai CRM Pada Universitas dengan Information Systems Success Model
Authors: Yani Herti , Beny Beny 
Published: May 2023

Social CRM memberikan kerangka kerja konseptual dan struktural baru yang berbasis pada Web 2.0 dan Media Sosial untuk mengarahkan kegiatan institusi pendidikan dalam menarik dan mempertahankan customer. Penelitian ini mengevaluasi pengukuran kesuksesan adopsi Social CRM pada perguruan tinggi dengan mengintegrasikan Critical Success Factors dan DeLone and McLean Information System Success Model. Evaluasi kesuksesan adopsi Social CRM pada perguruan tinggi dilakukan dengan menggunakan DeLone and McLean Information Systems Success Model dengan kriteria-kriteria komponen information quality, system quality dan service quality yang dirumuskan dari pengklasifikasian terhadap critical success factors. Hasil penelitian menunjukan variabel Information Quality berpengaruh terhadap variabel Use dengan tingkat signifikansi yaitu 0.000 (<0.05), variabel System Quality berpengaruh terhadap variabel Use secara signifikan dengan tingkat signifikansi 0.030 (<0.05), variabel System Quality berpengaruh terhadap User Satisfaction tingkat signifikansi 0.000 (<0.05), variabel Service Quality berpengaruh terhadap variabel Use dengan tingkat signifikansi 0.000 (<0.05), dan variabel Use berpengaruh terhadap variabel Net Benefit dengan tingkat signifikansi 0.000 (<0.05).
PERENCANAAN STRATEGIS SISTEM INFORMASI MENGGUNAKAN METODE WARD AND PEPPARD PADA GENTALA HOSPITALITY SCHOOL
Authors: Aryani Lies , Agustini Silvia Rianti , Andrianti Ari 
Published: May 2023

GENTALA HOSPIATLITY SCHOOL (GHS) merupakan Lembaga Pelatihan Kerja 1 tahun. Sistem Pendidikan-pelatihan yang dikembangkan di LPPK GHS Jambi yaitu berbasis kebutuhan kerja dari dunia usaha dan industry di bidang perhotelan, pariwisata dan kapal pesiar internasional. Proses bisnis utama pada LPPK GHS ini adalah mulai dari promosi, penerimaan siswa baru hingga penyaluran peserta didik untuk masuk ke dunia kerja. Untuk mencapai tujuan proses bisnis lembaga, maka diperlukan perencanaan strategis SI/TI untuk mengidentifikasi strategi dan teknologi yang digunakan sistem informasi sesuai dengan visi dan misi serta kebutuhan LPPK Gentala Hospitality School Jambi di masa mendatang.
Adapun tujuan utama dalam penelitian ini adalah menjabarkan metodologi ward and peppard sehingga dapat digunakan oleh lembaga untuk merumuskan perencanaan strategis terutama pada bidang SI/TI. Hasil dari penelitian berisikan rekomendasi penyempurnaan sistem informasi yang sudah ada dan penambahan sistem informasi baru, sehingga dapat digunakan secara maksimal untuk memenuhi kebutuhan bisnis lembaga.
Analisis UI/UX dan Front End Aplikasi Desain Rumah Menggunakan Human Centered Design
Authors: Sukriandi Salamun , Cahyono Nuri 
Published: May 2023

Jasa desain rumah mulai banyak diperlukan bagi masyarakat yang ingin membangun rumah dengan desain yang. Bulihuma memiliki kesulitan untuk bersaing dengan jasa desain rumah lainnya. Platform digital yang dinilai kurang memadai dan kantor yang belum diketahui banyak orang menjadi masalah utama Bulihuma dalam mendapatkan klien. Untuk itu diperlukan sebuah aplikasi khusus yang dapat meliputi jasa desain rumah ini secara detail. Dalam merancang sebuah aplikasi, terlebih dahulu harus dilakukan perancangan UI/UX agar nantinya aplikasi dapat dengan mudah digunakan oleh calon pengguna. Dalam perancangan aplikasi “Bulihuma” ini, menggunakan metode Human Centered Design dimana metode ini terdiri dari 3 tahapan yaitu Inspiration, Ideation, dan Implementation. Pengujian dilakukan kepada 15 pengguna yang telah memenuhi kriteria. Hasil akhir yang didapat pada penelitian ini yaitu mendapatkan 98% dalam aspek efektifitas, 91,52% dalam aspek efisiensi, dan 86,33 dalam System Usability Scale. Hasil ini termasuk dalam kategori “Acceptable” pada Acceptability Ranges, mendapatkan grade ”B” pada Grade Scale, dan masuk dalam kategori “Excellent” dalam Adjective Ratings.
Perbandingan Algoritma K-Means dan Fuzzy C-Means Untuk Clustering Puskesmas Berdasarkan Gizi Balita Surabaya
Authors: Kurnia Alvin 
Published: May 2023

Lingkungan yang berpenyakit dan rendahnya kesadaran masyarakat akan kebersihan lingkungan di beberapa kota di Indonesia membuat banyak orang terutama anak kecil rentan terhadap berbagai penyakit. Pada 63 Puskesmas yang ada di Kota Surabaya telah menimbang 148720 balita. Terdapat 4,2% balita dengan gizi kurang, 0,1% balita gizi buruk dan 4,5% balita gizi stunting. Clustering adalah suatu teknik dalam data mining yang bertujuan untuk mengelompokkan objek (data) ke dalam beberapa cluster atau kelompok sehingga objek yang serupa disatukan ke dalam cluster yang sama. metode ini adalah untuk melakukan penerapan, pengujian, serta evaluasi terhadap algoritma K-Means dan Fuzzy C-Means dalam melakukan clustering. sehingga hasil dari penelitian ini adalah untuk mengelompokkan Puskesmas berdasarkan gizi balita yang ada di Kota Surabaya. Hasil terbaik silhouette coefficient dari K-Means dengan proses Normalization adalah 0.51833215835383. Sedangkan hasil terbaik pada algoritma Fuzzy C-Means dengan proses Normalization adalah 0.49666983222478. Sehingga dapat disimpulkan bahwa pada clustering Puskesmas berdasarkan gizi balita Kota Surabaya algoritma K-Means lebih baik.
Implementasi Algoritma SIFT (Scale-Invariant Feature Transform) Dan Algoritma Kalman Filter Dalam Mendeteksi Objek Bola
Authors: Saputra Chindra 
Published: May 2023

Kontes Robot Sepak Bola Indonesia (KRSBI) merupakan salah satu divisi dari Kontes Robot Indonesia (KRI) yang diadakan oleh RISTEKDIKTI dan KEMENDIKBUD setiap tahunnya. Dalam kontes robot sepak bola, robot di tuntut untuk bisa mendeteksi bola dan kemudian menggiringnya ke gawang lawan agar dapat tercipta sebuah gol. istem pendeteksian objek yang baik haruslah cepat, ringan, dan tentu saja harus memiliki akurasi yang baik. Saat ini, sistem pendeteksian objek yang telah diterapkan pada robot yaitu berupa color filtering (penyaringan warna) yang dinilai cukup baik dalam mendeteksi sebuah objek. Namun jika hanya mengandalkan metode ini dirasa masih kurang jika di lihat dari segi tracking objek. Algoritma Kalman Filter berfungsi sebagai estimator yang dapat digunakan untuk memprediksi arah pergerakan dari suatu objek berdasarkan status objek dari frame sebelumnya. Hal ini membuat robot dapat bergerak lebih cepat 1 (satu) frame dari pada objek yang akan di tracking. Algoritma SIFT dapat membandingkan dua citra melalui feature yang dimiliki citra tersebut dan menghasilkan apakah citra tersebut memiliki kemiripan atau tidak, algoritma ini berguna untuk memastikan apakah objek yang dideteksi oleh robot itu bola atau bukan. Oleh sebab itu, penulis akan mencoba menggabungkan kedua algoritma ini apakah dapat menghasilkan sistem pendeteksian yang lebih baik dari sebelumnya. Diharapkan agar hasil dari penelitian ini dapat dipergunakan oleh robot dalam mengikuti kontes robot sepak bola Indonesia.
Faktor yang Mempengaruhi Niat Pembelian Kembali Oleh Konsumen Produk Kecantikan Yang Hanya Dijual Secara Online
Authors: Putri Karryn Krisnia , Thomas Thomas , Natanegara Wira , Soesilo Primidya Kartika Miranda 
Published: May 2023

This study aims to further examine the factors that influence Repurchase Intention, where these factors are Brand Personality, Brand Equity, Brand Familiarity, and Word of Mouth. Alongside the development of the market, we found that beauty products that are only sold online and offline have a good role in the e-commerce market to help Indonesia's economic development. We further researched specific beauty products that are only sold online, because there are differences between brands that are only sold online and brands that have offline stores. Then the number of consumers who buy beauty products that are only sold online is increasing every year, so this leads us to the discovery that there is an influence on Repurchase Intention from the Brand Equity and Brand Familiarity factors. Then on Brand Personality and Word of Mouth there is no effect on Repurchase Intention. In this study, we used quantitative methods as our research method, namely using regression which we processed based on results from online surveys. The results of the research that we get are in the form of two variables that affect re-purchase intention, namely brand equity and brand familiarity, while brand personality and word of mouth have no influence on the results of this study.