bluuebunny/crossref_metadata_2025_split huggingface dataset:
The synergistic effect of EMT regulators and m6A modification on prognosis-related immunological signatures for ovarian cancer
Authors: Zhang Yanna , Wang Xun , Duan Xiaogang , Du Ting , Chen Xiancheng 
Published: September 2023

AbstractRecently, there has been growing interest among researchers in exploring the effects of epithelial-mesenchymal transformation (EMT) or N6-Methyladenosine (m6A) modification regulators on tumor development. However, the synergistic efficiency of these regulators in relation to ovarian cancer development remains unclear. This study aims to explore the transcription patterns of main regulators, including 19 EMT and 22 m6A, in ovarian cancer samples from TCGA datasets and normal samples from GTEx datasets. After conducting a LASSO regression analysis, ten prognostic signatures were identified, namely KIAA1429, WTAP, SNAI1, AXL, IGF2BP1, ELAVL1, CBLL1, CDH2, NANOG and ALKBH5. These signatures were found to have a comprehensive effect on immune infiltrating signatures and the final prognostic outcome. Next, utilizing the ssGSEA algorithm and conducting overall survival analyses, we have identified the key prognosis-related immunological signatures in ovarian cancer to be ALKBH5, WTAP, ELAVL1, and CDH2 as the regulators. The characteristic immune response and related genetic expression have revealed a significant correlation between the alteration of m6A regulators and EMT regulators, indicating a synergistic effect between these two factors in the development of ovarian cancer. In summary, our research offers a novel perspective and strategy to enhance the occurrence, progression, and prognosis of ovarian cancer.
Eyelash length attractiveness across ethnicities
Authors: Pazhoohi Farid , Kingstone Alan 
Published: September 2023

AbstractEyelashes evolved to protect eyes. An optimum eyelash length functions to protect eyes from external hazards such as contaminations, excessive evaporation or shear stress from airflow. They can also be an indicator of a person's health as various congenital and noncongenital diseases can lead to short or long eyelashes. The current study aimed to extend a recent investigation on the preference for eyelash length in humans from an evolutionary adaptive perspective. Specifically, the current study tested whether the inverted-U function for eyelash length preference recently reported for White faces, generalises to other ethnicities, and whether ethnic background modulates preference for eyelash lengths. To investigate this question, men and women of Asian, Black, and White ethnicities from the U.S. rated the attractiveness of female Indian, Asian, Black, and White faces with varying eyelash lengths. The eyelashes ranged in length from no eyelashes to half the width of an eye. Results showed that Asian, Black, and White men and women preference for eyelash length followed an inverted-U function across all four ethnicities, supporting a general preference for human eyelash length that is approximately one-third the width of an eye. In addition, the results showed that the most attractive eyelashes for Black women were skewed toward a greater eyelash-length to eye-width ratio when compared to the other images. The source of this skew is presently unknown, as it could reflect a change in perceptual sensitivity to eyelash length with skin colour or changes in preference related to perceptions of participants’ ethnicity.
Cerebellar growth, volume and diffusivity in children cooled for neonatal encephalopathy without cerebral palsy
Authors: Wu Chelsea Q. , Cowan Frances M. , Jary Sally , Thoresen Marianne , Chakkarapani Ela , Spencer Arthur P. C. 
Published: September 2023

AbstractChildren cooled for HIE and who did not develop cerebral palsy (CP) still underperform at early school age in motor and cognitive domains and have altered supra-tentorial brain volumes and white matter connectivity. We obtained T1-weighted and diffusion-weighted MRI, motor (MABC-2) and cognitive (WISC-IV) scores from children aged 6–8 years who were cooled for HIE secondary to perinatal asphyxia without CP (cases), and controls matched for age, sex, and socioeconomic status. In 35 case children, we measured cerebellar growth from infancy (age 4–15 days after birth) to childhood. In childhood, cerebellar volumes were measured in 26 cases and 23 controls. Diffusion properties (mean diffusivity, MD and fractional anisotropy, FA) were calculated in 24 cases and 19 controls, in 9 cerebellar regions. Cases with FSIQ ≤ 85 had reduced growth of cerebellar width compared to those with FSIQ > 85 (p = 0.0005). Regional cerebellar volumes were smaller in cases compared to controls (p < 0.05); these differences were not significant when normalised to total brain volume. There were no case–control differences in MD or FA. Interposed nucleus volume was more strongly associated with IQ in cases than in controls (p = 0.0196). Other associations with developmental outcome did not differ between cases and controls.
Endemic characteristics of SARS-CoV-2 infection
Authors: Nesteruk Igor 
Published: September 2023

AbstractThe fourth year of the COVID-19 pandemic without decreasing trends in the global numbers of new daily cases, high numbers of circulating SARS-CoV-2 variants and re-infections together with pessimistic predictions for the Omicron wave duration force studies about the endemic stage of the disease. The global trends were illustrated with the use the accumulated numbers of laboratory-confirmed COVID-19 cases and deaths, the percentages of fully vaccinated people and boosters (additional vaccinations), and the results of calculation of the effective reproduction number provided by Johns Hopkins University. A new modified SIR model with re-infections was proposed and analyzed. The estimated parameters of equilibrium show that the global numbers of new daily cases will range between 300 thousand and one million, daily deaths—between one and 3.3 thousand.
Deterministic-stochastic analysis of fractional differential equations malnutrition model with random perturbations and crossover effects
Authors: Chu Yu-Ming , Rashid Saima , Karim Shazia , Khalid Aasma , Elagan S. K. 
Published: September 2023

AbstractTo boost the handful of nutrient-dense individuals in the societal structure, adequate health care documentation and comprehension are permitted. This will strengthen and optimize the well-being of the community, particularly the girls and women of the community that are welcoming the new generation. In this article, we extensively explored a deterministic-stochastic malnutrition model involving nonlinear perturbation via piecewise fractional operators techniques. This novel concept leads us to analyze and predict the process from the beginning to the end of the well-being growth, as it offers the possibility to observe many behaviors from cross over to stochastic processes. Moreover, the piecewise differential operators, which can be constructed with operators such as classical, Caputo, Caputo-Fabrizio, Atangana-Baleanu and stochastic derivative. The threshold parameter is developed and the role of malnutrition in society is examined. Through a rigorous analysis, we first demonstrated that the stochastic model’s solution is positive and global. Then, using appropriate stochastic Lyapunov candidates, we examined whether the stochastic system acknowledges a unique ergodic stationary distribution. The objective of this investigation is to design a nutritional deficiency in pregnant women using a piecewise fractional differential equation scheme. We examined multiple options and outlined numerical methods of coping with problems. To exemplify the effectiveness of the suggested concept, graphical conclusions, including chaotic and random perturbation patterns, are supplied. Consequently, fractional calculus’ innovative aspects provide more powerful and flexible layouts, enabling us to more effectively adapt to the system dynamics tendencies of real-world representations. This has opened new doors to readers in different disciplines and enabled them to capture different behaviors at different time intervals.
CSL-Tox: an open-source analytical framework for the comparison of short-term and long-term toxicity end points and assessing the need of chronic studies in drug development
Authors: Naga Doha , Dimitrakopoulou Smaragda , Roberts Sonia , Husar Elisabeth , Mohr Susanne , Booler Helen , Musvasva Eunice 
Published: September 2023

AbstractIn-vivo toxicity assessment is an important step prior to clinical development and is still the main source of data for overall risk assessment of a new molecular entity (NCE). All in-vivo studies are performed according to regulatory requirements and many efforts have been exerted to minimize these studies in accordance with the (Replacement, Reduction and Refinement) 3Rs principle. Many aspects of in-vivo toxicology packages can be optimized to reduce animal use, including the number of studies performed as well as study durations, which is the main focus of this analysis. We performed a statistical comparison of adverse findings observed in 116 short-term versus 78 long-term in-house or in-house sponsored Contract Research Organizations (CRO) studies, in order to explore the possibility of using only short-term studies as a prediction tool for the longer-term effects. All the data analyzed in this study was manually extracted from the toxicology reports (in PDF formats) to construct the dataset. Annotation of treatment related findings was one of the challenges faced during this work. A specific focus was therefore put on the summary and conclusion sections of the reports since they contain expert assessments on whether the findings were considered adverse or were attributed to other reasons. Our analysis showed a general good concordance between short-term and long-term toxicity findings for large molecules and the majority of small molecules. Less concordance was seen for certain body organs, which can be named as “target organ systems’ findings”. While this work supports the minimization of long-term studies, a larger-scale effort would be needed to provide more evidence. We therefore present the steps performed in this study as an open-source R workflow for the Comparison of Short-term and Long-term Toxicity studies (CSL-Tox). The dataset used in the work is provided to allow researchers to reproduce such analysis, re-evaluate the statistical tools used and promote large-scale application of this study. Important aspects of animal research reproducibility are highlighted in this work, specifically, the necessity of a reproducible adverse effects reporting system and utilization of the controlled terminologies in-vivo toxicology reports and finally the importance of open-source analytical workflows that can be assessed by other scientists in the field of preclinical toxicology.
Heat and mass transfer analysis of assisting and opposing radiative flow conveying ternary hybrid nanofluid over an exponentially stretching surface
Authors: Nagaraja K. V. , Khan Umair , Madhukesh J. K. , Hassan Ahmed M. , Prasannakumara B. C. , Ben Kahla Nabil , Elattar Samia , Singh Chohan Jasgurpreet 
Published: September 2023

AbstractAccess to dependable and environmentally friendly energy sources is critical to a country's economic growth and long-term development. As countries seek greener energy alternatives, the interaction of environmental elements, temperature, and sunlight becomes more critical in utilizing renewable energy sources such as wind and bioenergy. Solar power has received much attention due to extraordinary efficiency advances. under this context, the present work focus on solar radiation and chemical processes in the presence of modified ternary hybrid nanofluids (THNFs) circulating over an exponentially stretched surface in both aiding flow (A-F) and opposing flow (O-F) circumstances. The primary objective of this investigation is to dive into the complicated dynamics of these structures, which are distinguished by complex interactions involving radiation, chemical reactions, and the movement of fluids. We construct reduced ordinary differential equations from the governing equations using suitable similarity transformations, which allows for a more in-depth examination of the liquid's behavior. Numerical simulations using the Runge–Kutta Fehlberg (RKF) approach and shooting techniques are used to understand the underlying difficulties of these reduced equations. The results show that thermal radiation improves heat transmission substantially under O-F circumstances in contrast to A-F conditions. Furthermore, the reaction rate parameter has an exciting connection with concentration levels, with greater rates corresponding to lower concentrations. Furthermore, compared to the O-F scenario, the A-F scenario promotes higher heat transfer in the context of a modified nanofluid. Rising reaction rate and solid fraction volume enhanced mass transfer rate. The rate of thermal distribution in THNFs improves from 0.13 to 20.4% in A-F and 0.16 to 15.06% in O-F case when compared to HNFs. This study has real-world implications in several fields, including developing more efficient solar water heaters, solar thermal generating plants, and energy-saving air conditioners.
Association between adherence to the Mediterranean diet with cardiometabolic risk factors: a cross-sectional study on PERSIAN cohort study in Fasa
Authors: Bagheri Milad , Nouri Mehran , Homayounfar Reza , Akhlaghi Masoumeh 
Published: September 2023

AbstractThe relationship between Mediterranean diet and obesity-related markers is a matter of debate. We investigated the association between adherence to the Mediterranean diet and anthropometric indices, body composition, and cardiometabolic risk factors in Iranian population. The cross-sectional study was performed on data of 3386 participants from Fasa PERSIAN cohort study. The Mediterranean diet score (MDS) was calculated based on consumption of 11 food groups (unrefined cereals, potatoes, fruits, vegetables, legumes, fish, red meat, poultry, dairy, olive oil, and alcoholic beverages). The association between MDS and cardiometabolic risk factors was examined by linear regression analysis. MDS was inversely associated with waist circumference (β =  − 1.11; P = 0.033), waist-to-hip ratio (β =  − 0.007; P = 0.011), waist-to-height ratio (β =  − 0.009; P = 0.015), fasting glucose (β =  − 3.59; P = 0.001), and HDL-cholesterol (β =  − 0.96; P = 0.031) in unadjusted model. After adjusting for energy intake, the associations of MDS with markers of abdominal obesity and HDL-cholesterol disappeared. In fully adjusted model, MDS showed inverse relationships with waist-to-hip ratio (β =  − 0.005; P = 0.037) and fasting glucose (β =  − 2.71; P = 0.013). In conclusion, MDS showed an inverse relationship with fasting glucose and waist-to-hip ratio. Since energy intake increased along with increasing MDS, adherence to the Mediterranean diet may associate with lower abdominal obesity and better glycemic control if an energy-controlled Mediterranean diet is used.
Dead-time compensation in three-phase grid-tied inverters using LQG multivariable control
Authors: Mazaheri Ali , Barati Farhad , Ghavipanjeh Farideh 
Published: September 2023

AbstractDead-time is the most important disturbance in a voltage-source inverter’s operation. It introduces low-order harmonics at the inverter’s output voltage. To compensate for the dead-time effects in three-phase grid-tied inverters, this paper proposes a Linear Quadratic Gaussian (LQG) multivariable control approach. The LQG multivariable control is known as a robust control approach while provides a high band-width for the closed-loop system. Therefore, it promises significant attenuations in the dead-time introduced harmonics. To achieve a high performance, we run the three-phase grid-tied inverter in the current-controlled mode. Based on the nominal multivariable model derived for the three-phase grid-tied inverter in a synchronous reference frame, the LQG controller is composed such that the closed-loop system exhibits robust stability while attenuates disturbances significantly. The dead-time introduced harmonics produce disturbances in the synchronous reference frame with the highest frequencies. This is the reason for considering the dead-time as the most important disturbance in an inverter’s operation. For an experimental set-up manufactured for the three-phase grid-tied inverter, we developed a detailed model in MATLAB/Simulink. It is employed for the performance verifications of designed LQG controller. Extensive results are presented for different important scenarios, based on which, the excellent performance of proposed approach is proven. In fact, by employing the proposed approach, the dead-time introduced harmonics are significantly attenuated such that a Total Harmonics Distortions (THD) of about 5% is achieved for the injected currents to grid which meets the IEEE 1547 standard.
Population genomic analysis of an emerging pathogen Lonsdalea quercina affecting various species of oaks in western North America
Authors: Kozhar Olga , Sitz Rachael A. , Woyda Reed , Legg Lillian , Ibarra Caballero Jorge R. , Pearse Ian S. , Abdo Zaid , Stewart Jane E. 
Published: September 2023

AbstractUnderstanding processes leading to disease emergence is important for effective disease management and prevention of future epidemics. Utilizing whole genome sequencing, we studied the phylogenetic relationship and diversity of two populations of the bacterial oak pathogen Lonsdalea quercina from western North America (Colorado and California) and compared these populations to other Lonsdalea species found worldwide. Phylogenetic analysis separated Colorado and California populations into two Lonsdalea clades, with genetic divergence near species boundaries, suggesting long isolation and populations that differ in genetic structure and distribution and possibly their polyphyletic origin. Genotypes collected from different host species and habitats were randomly distributed within the California cluster. Most Colorado isolates from introduced planted trees, however, were distinct from three isolates collected from a natural stand of Colorado native Quercus gambelii, indicating cryptic population structure. The California identical core genotypes distribution varied, while Colorado identical core genotypes were always collected from neighboring trees. Despite its recent emergence, the Colorado population had higher nucleotide diversity, possibly due to its long presence in Colorado or due to migrants moving with nursery stock. Overall, results suggest independent pathogen emergence in two states likely driven by changes in host-microbe interactions due to ecosystems changes. Further studies are warranted to understand evolutionary relationships among L. quercina from different areas, including the red oak native habitat in northeastern USA.
Probing magnetic properties at the nanoscale: in-situ Hall measurements in a TEM
Authors: Pohl Darius , Lee Yejin , Kriegner Dominik , Beckert Sebastian , Schneider Sebastian , Rellinghaus Bernd , Thomas Andy 
Published: September 2023

AbstractWe report on advanced in-situ magneto-transport measurements in a transmission electron microscope. The approach allows for concurrent magnetic imaging and high resolution structural and chemical characterization of the same sample. Proof-of-principle in-situ Hall measurements on presumably undemanding nickel thin films supported by micromagnetic simulations reveal that in samples with non-trivial structures and/or compositions, detailed knowledge of the latter is indispensable for a thorough understanding and reliable interpretation of the magneto-transport data. The proposed in-situ approach is thus expected to contribute to a better understanding of the Hall signatures in more complex magnetic textures.
Adhesion-regulating molecule 1 (ADRM1) can be a potential biomarker and target for bladder cancer
Authors: Yu Qing-xin , Wang Jiao-chen , Liu Jun-fei , Ye Lu-xia , Guo Yi-qing , Zheng Hai-hong 
Published: September 2023

AbstractAdhesion-regulating molecule 1 (ADRM1) has been implicated in tumor development, yet its specific role in bladder cancer (BC) remains undefined. This study aimed to elucidate the function of ADRM1 in BC through a combination of bioinformatics analysis and immunohistochemical analysis (IHC). Utilizing R version 3.6.3 and relevant packages, we analyzed online database data. Validation was conducted through IHC data, approved by the Institutional Ethics Committee (Approval No. K20220830). In both paired and unpaired comparisons, ADRM1 expression was significantly elevated in BC tissues compared to adjacent tissues, as evidenced by the results of TCGA dataset and IHC data. Patients with high ADRM1 expression had statistically worse overall survival than those with low ADRM1 expression in TCGA dataset, GSE32548 dataset, GSE32894 dataset, and IHC data. Functional analysis unveiled enrichment in immune-related pathways, and a robust positive correlation emerged between ADRM1 expression and pivotal immune checkpoints, including CD274, PDCD1, and PDCD1LG2. In tumor microenvironment, samples with the high ADRM1 expression contained statistical higher proportion of CD8 + T cells and Macrophage infiltration. Meanwhile, these high ADRM1-expressing samples displayed elevated tumor mutation burden scores and stemness indices, implying potential benefits from immunotherapy. Patients with low ADRM1 expression were sensitive to cisplatin, docetaxel, vinblastine, mitomycin C, and methotrexate. According to the findings from bioinformatics and IHC analyses, ADRM1 demonstrates prognostic significance for BC patients and holds predictive potential for both immunotherapy and chemotherapy responses. This underscores its role as a biomarker and therapeutic target in BC.
On the renormalization group fixed point of the two-dimensional Ising model at criticality
Authors: Stottmeister Alexander , Osborne Tobias J. 
Published: September 2023

AbstractWe analyze the renormalization group fixed point of the two-dimensional Ising model at criticality. In contrast with expectations from tensor network renormalization (TNR), we show that a simple, explicit analytic description of this fixed point using operator-algebraic renormalization (OAR) is possible. Specifically, the fixed point is characterized in terms of spin-spin correlation functions. Explicit error bounds for the approximation of continuum correlation functions are given.
Local ocular factors associated with the development of diabetic macular edema: an inter-eye study
Authors: Choi Jaehwan , Kim Sang Jin , Kang Se Woong , Son Ki Young , Hwang Sungsoon 
Published: September 2023

AbstractTo investigate local ocular factors associated with the development of diabetic macular edema (DME), we classified each eye of patients with unilateral DME as the DME eyes or the fellow eyes (without DME). We compared the clinical characteristics, optical coherence tomography (OCT), and OCT angiography (OCTA), ultra-wide field fundus photography, and angiography features of each eye. As a result, fifty-five patients with unilateral DME were enrolled. Although the diabetic retinopathy stage was not different between each group of eyes, DME eyes showed a higher prevalence of venous beading and a larger area of nonperfusion region than did fellow eyes (all P < 0.05). OCTA features of DME eyes also showed a larger foveal avascular zone in the deep capillary plexus and a lower vascular density in both the superficial and deep capillary plexuses (all P < 0.05). This study highlighted ocular features reflecting retinal ischemia, such as venous beading, area of nonperfusion region, and vascular density in the central retinal area, are associated with the development of DME. OCTA and ultra-wide field fluorescein angiography may be useful for evaluating the parameters of retinal ischemia and the risk of DME development.