bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of a contemporary credentialing and privileging program in a dental school
Authors: Robinson Fonda G. , Fields Henry W. , Marado Laura , Heinlein David J. , Larsen Peter E. , Kearney Rachel C. 
Published: January 2023

AbstractThe current credentialing and privileging (C&P) climate has evolved due to a risk reduction/management awareness of increased institutional legal liability. This recognition affects dental colleges and has caused the implementation of C&P processes. Contemporary best practices for methods, processes, and structure are reported here. Data reported from the process show how and what clinicians’ red flags were discovered during the process. Conclusions include the following: C&P is a significant process to introduce in terms of institutional resources and commitment. This process includes increased clinician and administrative burden that needs to have a governor. Attention to experiences of other institutions can reduce but not eliminate challenges from the clinician and some administrators. A primary data‐based verification process administered by a credentialing specialist can make the process valid and workable.
Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID‐19 severity
Authors: Prado Caroline Aliane de Souza , Fonseca Dennyson Leandro M. , Singh Youvika , Filgueiras Igor Salerno , Baiocchi Gabriela Crispim , Plaça Desirée Rodrigues , Marques Alexandre H. C. , Dantas‐Komatsu Raquel Costa Silva , Usuda Júlia N. , Freire Paula Paccielli , Salgado Ranieri Coelho , Napoleao Sarah Maria da Silva , Ramos Rodrigo Nalio , Rocha Vanderson , Zhou Guangyan , Catar Rusan , Moll Guido , Camara Niels Olsen Saraiva , de Miranda Gustavo Cabral , Calich Vera Lúcia Garcia , Giil Lasse M. , Mishra Neha , Tran Florian , Luchessi Andre Ducati , Nakaya Helder I. , Ochs Hans D. , Jurisica Igor , Schimke Lena F. , Cabral‐Marques Otavio 
Published: January 2023

AbstractSeveral perturbations in the number of peripheral blood leukocytes, such as neutrophilia and lymphopenia associated with Coronavirus disease 2019 (COVID‐19) severity, point to systemic molecular cell cycle alterations during severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection. However, the landscape of cell cycle alterations in COVID‐19 remains primarily unexplored. Here, we performed an integrative systems immunology analysis of publicly available proteome and transcriptome data to characterize global changes in the cell cycle signature of COVID‐19 patients. We found significantly enriched cell cycle‐associated gene co‐expression modules and an interconnected network of cell cycle‐associated differentially expressed proteins (DEPs) and genes (DEGs) by integrating the molecular data of 1469 individuals (981 SARS‐CoV‐2 infected patients and 488 controls [either healthy controls or individuals with other respiratory illnesses]). Among these DEPs and DEGs are several cyclins, cell division cycles, cyclin‐dependent kinases, and mini‐chromosome maintenance proteins. COVID‐19 patients partially shared the expression pattern of some cell cycle‐associated genes with other respiratory illnesses but exhibited some specific differential features. Notably, the cell cycle signature predominated in the patients' blood leukocytes (B, T, and natural killer cells) and was associated with COVID‐19 severity and disease trajectories. These results provide a unique global understanding of distinct alterations in cell cycle‐associated molecules in COVID‐19 patients, suggesting new putative pathways for therapeutic intervention.
Dispersive liquid‐liquid microextraction based on a supramolecular solvent followed by high‐performance liquid chromatographic analysis of lignans in Forsythiae Fructus
Authors: Qin Yu , Wang Run‐Qin , Xing Rong‐Rong , Yang Li , Chen Xuan , Hu Shuang 
Published: January 2023

A supramolecular solvent‐based dispersive liquid‐liquid microextraction was proposed for the extraction and determination of lignans in Forsythiae Fructus combined with high‐performance liquid chromatography. The supramolecular solvent, consisting of tetrabutylammonium bromide and n‐hexanol, was mixed with the sample solution to extract the analytes by a vortex. After accomplishing the extraction, the extraction phase was separated by centrifugation and collected for high‐performance liquid chromatography analysis. In this work, the important extraction variables such as the type and amount of extraction solvent, pH and salt amount in the sample phase, and extraction time were optimized. The synthesis of supramolecular solvent was studied and its microstructure was characterized by transmission electron microscopy. Under the optimal conditions, the analytes’ enrichment factors were between 6 and 170 for the proposed procedure. Satisfactory linear ranges (r ≥ 0.99), detection limits (0.025–0.4 ng/ml), precisions (< 9.2%), and accuracies (recoveries: 96.5%–104.8%) were obtained. The method has been successfully applied to the preconcentration of lignans in Forsythiae Fructus with simple and rapid operation, low cost, and environmental friendliness.
One model to rule them all: identifying priority bat habitats from multi‐species habitat suitability models
Authors: Gaulke Sarah M. , Cable Ashleigh B. , Hohoff Tara C. , Rogness Brittany A. , Davis Mark A. 
Published: January 2023

AbstractBats are important components of global ecosystems, providing essential ecosystem services with substantial economic benefit. Yet North American bat populations have been negatively affected by numerous factors (e.g., disease, habitat loss, wind energy development) with compounding effects. Bats use habitats at a variety of scales, from small, isolated patches to large, contiguous corridors. Landscape‐level research is necessary to identify important habitats, patches, and corridors to strategically target management interventions. We created habitat suitability models (HSMs) for hoary bats (Lasiurus cinereus), eastern red bats (L. borealis), and tri‐colored bats (Perimyotis subflavus) across Illinois, USA, using species‐specific landscape and climate variables. With the 3 models from this study and a previously published HSM for Indiana bats (Myotis sodalis), we stacked binary HSMs, thereby identifying priority conservation areas across Illinois. Species exhibited different distributional patterns and habitat preferences across Illinois. Multi‐species HSMs highlight high quality habitat (i.e., ecologically important habitat that provides preferred resources for roosting, foraging, and raising young) in southern Illinois and along river riparian areas. This approach identified priority conservation areas mainly following hydrologic zones, which allows managers to strategically target restoration and conservation measures, invest funds in habitat likely to have high return‐on‐investment, and assist with decisions that affect bats (e.g., siting wind turbines, purchasing mitigation lands).
Spatial and temporal drivers of fluorescence quantum yield variability in the Southern Ocean
Authors: Ryan‐Keogh Thomas James , Bone Emma Lewis , Thomalla Sandy J. , Lain Lisl , Smith Marie E. , Bernard Stewart , Vichi Marcello 
Published: January 2023

AbstractFluorescence quantum yield is a powerful tool for assessing phytoplankton photophysiology and photosynthetic efficiency, but there is a paucity of in situ studies. Here we present the first wavelength‐specific fluorescence quantum yield data from high spatial and temporal resolution real‐time measurements made in the Southern Ocean. This dataset represents both winter and summer conditions across a broad latitudinal range of the Atlantic and Indian South Ocean and the presented analysis assesses the potential influence of a range of physical, chemical, and biological drivers of variability. The results indicate that both light history and potential iron limitation play significant roles in constraining the magnitude of fluorescence quantum yield on a seasonal basis, with links to specific pigment composition of carotenoids involved in fluorescence quenching. Whereas community structure and associated pigment content play a strong role in dictating the spectral shape of fluorescence quantum yield both seasonally and spatially, with larger diatom‐dominated communities fluorescing more in the blue region of the spectrum and smaller phycoerythrin‐containing phytoplankton fluorescing more in the green‐orange region of the spectrum. This study provides a better understanding of the drivers of variability of in situ fluorescence quantum yield, which is useful for informing interpretations of studies based on remotely sensed signals, which are essential for investigating spatial and temporal variability in photophysiological characteristics on longer time scales.
Hybrid Dispersion Engineering based on Chiral Metamirror
Authors: Li Jinxing , Yuan Yueyi , Yang Guohui , Wu Qun , Zhang Wei , Burokur Shah Nawaz , Zhang Kuang 
Published: January 2023

AbstractDispersion is one of the key performances of optical systems. As a man‐made device, metasurface is a notable alternative for dispersion manipulation and has been developed vigorously in recent years. However, the currently reported dispersion manipulation principle of meta‐atoms only relies on controlling the propagation phase in the operation frequency band or several working wavelengths. In this paper, the chirality‐assisted phase is introduced as an additional degree of freedom to engineer the dispersion characteristics of the meta‐atom, and the strategy is theoretically demonstrated. The dispersion characteristic of the chiral meta‐atom working in a reflective manner is discussed in detail within the working bandwidth. Then, two hybrid dispersion‐engineered metamirrors (HDEMs) are proposed and constructed to demonstrate versatile dispersion manipulation in the working frequency band, including achromatic focusing for the lower half band and hyper dispersive focusing for the upper half band, and hyper dispersive focusing and abnormal dispersive focusing in the lower and upper half band, respectively. Both full‐wave simulation and measured performances verify the validity and flexibility of the proposed strategy. This work exploits a new degree of freedom for dispersion manipulation, providing a new approach for dispersion‐engineered metasurfaces design.
On‐Demand Cell Sheet Release with Low Density Peptide‐Functionalized Non‐LCST Polymer Brushes
Authors: Schulte Anna , de los Santos Pereira Andres , Pola Robert , Pop‐Georgievski Ognen , Jiang Siyu , Romanenko Iryna , Singh Manisha , Sedláková Zdeňka , Schönherr Holger , Poręba Rafał 
Published: January 2023

AbstractCell sheet harvesting offers a great potential for the development of new therapies for regenerative medicine. For cells to adhere onto surfaces, proliferate, and to be released on demand, thermoresponsive polymeric coatings are generally considered to be required. Herein, an alternative approach for the cell sheet harvesting and rapid release on demand is reported, circumventing the use of thermoresponsive materials. This approach is based on the end‐group biofunctionalization of non‐thermoresponsive and antifouling poly(2‐hydroxyethyl methacrylate) (p(HEMA)) brushes with cell‐adhesive peptide motifs. While the nonfunctionalized p(HEMA) surfaces are cell‐repellant, ligation of cell‐signaling ligand enables extensive attachment and proliferation of NIH 3T3 fibroblasts until the formation of a confluent cell layer. Remarkably, the formed cell sheets can be released from the surfaces by gentle rinsing with cell‐culture medium. The release of the cells is found to be facilitated by low surface density of cell‐adhesive peptides, as confirmed by X‐ray photoelectron spectroscopy. Additionally, the developed system affords possibility for repeated cell seeding, proliferation, and release on previously used substrates without any additional pretreatment steps. This new approach represents an alternative to thermally triggered cell‐sheet harvesting platforms, offering possibility of capture and proliferation of various rare cell lines via appropriate selection of the cell‐adhesive ligand.
Effect of Topology on the Collapse Transition and the Instantaneous Shape of a Model Heteropolymer
Authors: Singh Thoudam Vilip , Shagolsem Lenin S. 
Published: January 2023

AbstractThe effect of topology on the collapse transition and instantaneous shape of an energy polydisperse polymer (EPP), a model heteropolymer is studied by means of computer simulations. In particular, three different chain topologies, namely, linear (L), ring (R), and trefoil knot (T), are considered. The heteropolymer is modeled by assigning each monomer an interaction parameter, εi, drawn randomly from a Gaussian distribution. Through chain size scaling, the transition temperature, θ, is located and compared among the chains of different topologies. The influence of topology is reflected in the value of θ and observed that θ(L) > θ(R) > θ(T) in a similar fashion to that of the homopolymer counterpart. Also studied chain size distributions, and the shape changes across the transition temperature characterized through shape parameters based on the eigenvalues of the gyration tensor. It is observed that, for the model heteropolymer, in addition to chain topology, the θ‐temperature also depends on energy polydispersity.
Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta
Authors: Wang Ernest W. , Brown Gregory L. , Lewis Mechelle M. , Jellen Leslie C. , Pu Cunfeng , Johnson Melinda L. , Chen Hairong , Kong Lan , Du Guangwei , Huang Xuemei 
Published: January 2023

ABSTRACTBackgroundSusceptibility magnetic resonance imaging (MRI) is sensitive to iron‐related changes in the substantia nigra pars compacta (SNc), the key pathologic locus of parkinsonisms. It is unclear, however, if iron deposition in the SNc is associated with its neurodegeneration.ObjectiveThe objective of this study was to test whether susceptibility MRI metrics in parkinsonisms are associated with SNc neuropathologic features of dopaminergic neuron loss, gliosis, and α‐synuclein and tau burden.MethodsThis retrospective study included 27 subjects with both in vivo MRI and postmortem data. Multigradient echo imaging was used to derive the apparent transverse relaxation rate (R2*) and quantitative susceptibility mapping (QSM) in the SNc. Archived midbrain slides that were stained with hematoxylin and eosin, anti‐α‐synuclein, and anti‐tau were digitized to quantify neuromelanin‐positive neuron density, glial density, and the percentages of area occupied by positive α‐synuclein and tau staining. MRI‐histology associations were examined using Pearson correlations and regression.ResultsTwenty‐four subjects had postmortem parkinsonism diagnoses (Lewy body disorder, progressive supranuclear palsy, multiple system atrophy, and corticobasal degeneration), two had only Alzheimer's neuropathology, and one exhibited only mild atrophy. Among all subjects, both R2* and QSM were associated with glial density (r ≥ 0.67; P < 0.001) and log‐transformed tau burden (r ≥ 0.53; P ≤ 0.007). Multiple linear regression identified glial density and log‐transformed tau as determinants for both MRI metrics (R2 ≥ 0.580; P < 0.0001). Neither MRI metric was associated with neuron density or α‐synuclein burden.ConclusionsR2* and QSM are associated with both glial density and tau burden, key neuropathologic features in the parkinsonism SNc. © 2023 International Parkinson and Movement Disorder Society.
Wideband high gain SIW horn antenna loaded with half Maxwell fish‐eye fabricated by 3‐D‐printing
Authors: Lei Siyuan , Wei Gao , Han Kangkang , Li Xianlei 
Published: January 2023

AbstractThis letter presents a wideband high gain substrate integrated waveguide horn antenna (SIWHA) loaded with half Maxwell fish‐eye (HMFE) fabricated by 3‐D‐Printing. The impedance bandwidth of the SIWHA is narrow, mainly caused by the discontinuity between the substrate with the air. By introducing the HMFE and a match layer between the SIWHA with HMFE, the impedance continuity can be realized, which can not only improve the impedance bandwidth but also enhance the antenna gain. Experimental results show that the proposed antenna can achieve more than 6 dBi gain and 60.9% relative impedance bandwidth with reflection coefficients lower than −10 dB.
Design of a circularly polarized printed open‐slot antenna using theory of characteristic modes
Authors: Ellis Mubarak S. , Owusu‐Achiaw Nana Afia , Osei Stephen Asante , Nakojah David 
Published: January 2023

AbstractIn this paper, modal analysis is used as a guide to design a circularly polarized open‐slot antenna. The design proposes an open wide slot that is fed electromagnetically by a modified feedline. Both open slot and feedline are asymmetrically placed to the edge of the substrate. The complete antenna without excitation is analyzed using characteristic mode theory to provide a physical insight into its circular polarization operation. The modal analysis proves that several nearly orthogonal modes can be generated at certain frequencies with 90° phase differences. The axial ratio (AR) corresponds to the modal analysis, which proves the validity of the modal analysis. An AR bandwidth from 3.2 to 6 GHz (61%) is achieved within an S11 bandwidth of 3.2–14 GHz (125%). The proposed antenna achieves a peak realized gain 4.3 dBi of within the AR band.
Balanced bandpass microstrip filter with high common‐mode rejection and extended stopband
Authors: Romero‐Ramirez Miguel‐Antonio , Olvera‐Cervantes Jose‐Luis , Kataria Tejinder K. , Corona‐Chavez Alonso 
Published: January 2023

AbstractA balanced bandpass filter (BBPF) with high common‐mode rejection (CMR) and extended differential‐mode (DM) stopband is presented. It is based on miniaturized Pi‐network ring resonators with loaded inductors. This structure permits the design of the common‐mode (CM) and DM resonances independently, which gives plenty of flexibility when designing the filter. Stubs are added along the symmetry plane to improve the CMR. A microstrip BBPF is designed at 921.7 MHz with a fractional bandwidth of 8.4% and a DM stopband of 10.13 for S21 < −30 dB. The CMR is better than −20 dB up to 10 .
Technical note: Investigating the suitability of existing facilities for a new Lu‐177 prostate‐specific membrane antigen therapy program
Authors: Murtha N. , Morrison H. , Roumeliotis M. , Quirk S. , Smith W. , Blais A. 
Published: January 2023

AbstractBackground177Lu prostate‐specific membrane antigen (PSMA) therapy prolongs survival for some prostate cancer patients. To adopt this technique, institutions may need to evaluate the suitability of existing infrastructure.PurposeDevelop a methodology to determine whether existing facilities can accommodate a 177Lu‐PSMA therapy program.MethodsRoom suitability is defined by both the ability to accommodate 177Lu‐PSMA therapy workflow and to provide appropriate radiation shielding. Two methods of shielding calculation were performed: (1) National Council on Radiation Protection and Measurements report 151 (NCRP‐151), with workload defined in terms of the activity of 177Lu administered, and (2) using the RadPro shielding calculator. This methodology was applied to 131I therapy, PET‐CT uptake, PET‐SPECT injection, and orthovoltage therapy rooms.Results131I therapy rooms were found to meet both shielding and workflow requirements. The shielding was found to be adequate for orthovoltage and PET‐SPECT facilities, neglecting patient transit between external washrooms. The workflow was the limiting factor for these rooms due to the requirement of dedicated washrooms that shield the patient and contain possible contamination. The PET‐CT facility did not meet either criteria. The NCRP‐151 method generally predicted a higher dose rate on the other side of shielding than did the RadPro calculator. The dose rate on the other side of concrete shielding as predicted by the NCRP‐151 method increased relative to the dose rate predicted by the RadPro calculator as shielding thickness increased. For lead shielding, the dose rate predicted by the NCRP‐151 method decreased relative to the result predicted by the RadPro calculator with increasing material thickness.Conclusions131I therapy, PET‐CT uptake, PET‐SPECT injection, and orthovoltage therapy rooms were considered. The 131I treatment rooms were the best candidate for 177Lu‐PSMA therapy, due to their shielding and capability to accommodate the necessary workflow.
Clinically significant anxiety as a risk factor for Alzheimer's disease: Results from a 10‐year follow‐up community study
Authors: Gracia‐García Patricia , Bueno‐Notivol Juan , Lipnicki Darren M. , de la Cámara Concepción , Lobo Antonio , Santabárbara Javier 
Published: January 2023

AbstractObjectiveThere is growing evidence for an association between anxiety and an increased risk of dementia, but it is not clear whether anxiety is a risk factor or a prodromic symptom. In this study, we investigated if clinically significant anxiety increases the risk of developing Alzheimer's disease (AD) up to 10 years later.MethodsWe used data from the longitudinal Zaragoza Dementia and Depression (ZARADEMP) Project. Excluding subjects with dementia at baseline left us with 3044 individuals aged >65 years. The Geriatric Mental State‐Automated Geriatric Examination for Computer Assisted Taxonomy (GMS‐AGECAT) package was used to identify cases and subcases of anxiety. AD was diagnosed by a panel of research psychiatrists according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM‐IV) criteria. Multivariate survival analysis with a competing risk regression model was performed.ResultsWe observed a significant association between clinically significant anxiety at baseline and AD risk within a 10‐year follow‐up (SHR 2.82 [95% CI 1.21–6.58]), after controlling for confounders including depression. In contrast, isolated symptoms of anxiety were not significantly associated with an increased incidence of AD.ConclusionOur results support the hypothesis that clinically significant anxiety is an independent risk factor for AD and not just a prodromic symptom. Future studies should clarify if treating anxiety reduces the incidence of AD.
Comprehensive analysis of nonsurrounded nucleolus and surrounded nucleolus oocytes on chromatin accessibility using ATAC‐seq
Authors: Sun Xiaofan , Wang Dayu , Li Weijian , Gao Qian , Tao Jingli , Liu Honglin 
Published: January 2023

AbstractMouse germinal vesicle (GV) oocytes are divided into surrounded nucleolus (SN) and nonsurrounded nucleolus (NSN) oocytes based on chromatin morphology. NSN oocytes spontaneously transform into SN oocytes after accumulating enough maternal transcripts. SN oocytes show transcriptional silencing. When oocyte maturation is abnormal or takes place in vitro, NSN oocytes do not go through SN stage before proceeding to MII. Nontransitive oocytes show developmental retardation, a low fertilization rate, and arrest at the two‐cell embryo stage in mice. Here, chromatin‐binding ribonucleic acid polymerase II (RNAP II) activity, newly synthesized RNA, and chromatin accessibility in GV oocytes were examined. In SN oocytes, RNAP II did not bind to DNA, neo‐RNA was not generated in nuclei, and the phosphorylation state of RNAP II did not affect the chromatin‐binding activity. The number of accessible genes in SN oocytes was remarkably lower than that in NSN oocytes. The accessibility of different functional genes was also different between the two types of oocytes. Thus, low chromatin accessibility leads to transcriptional silencing in SN oocytes.