bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of reporting of prospective in vivo and ex vivo studies published in the Journal of Veterinary Emergency and Critical Care over a 10‐year period (2009–2019)
Authors: Bergen Paige , Munro Brittany A. , Pang Daniel S. J. 
Published: July 2023

AbstractObjectiveTo evaluate the reporting of key items associated with risk of bias and weak study design over a 10‐year period.DesignLiterature survey.SettingNot applicable.AnimalsNot applicable.InterventionsPapers published in the Journal of Veterinary Emergency and Critical Care between 2009 and 2019 were screened for inclusion. Inclusion criteria consisted of prospective experimental studies describing in vivo or ex vivo research (or both), containing at least 2 comparison groups. Identified papers had identifying information (publication date, volume and issue, authors, affiliations) redacted by an individual not involved with paper selection or review. Two reviewers independently reviewed all papers and applied an operationalized checklist to categorize item reporting as fully reported, partially reported, not reported, or not applicable. Items assessed included randomization, blinding, data handling (inclusions and exclusions), and sample size estimation. Differences in assessment between reviewers were resolved by consensus with a third reviewer. A secondary aim was to document availability of data used to generate study results. Papers were screened for links to access data in the text and supporting information.Measurements and Main ResultsAfter screening, 109 papers were included. Eleven papers were excluded during full‐text review, with 98 papers included in the final analysis. Randomization was fully reported in 31.6% of papers (31/98). Blinding was fully reported in 31.6% of papers (31/98). Inclusion criteria were fully reported in all papers. Exclusion criteria were fully reported in 60.2% of papers (59/98). Sample size estimation was fully reported in 8.0% of papers (6/75). No papers (0/99) made data freely available without a requirement to contact study authors.ConclusionsThere is substantial room for improvement in reporting of randomization, blinding, data exclusions, and sample size estimations. Evaluation of study quality by readers is limited by the low reporting levels identified, and the risk of bias present indicates a potential for inflated effect sizes.
Phenibut toxicosis in a dog
Authors: Sahagian Michael , Mastrocco Alicia , Prittie Jennifer 
Published: July 2023

AbstractObjectiveTo describe the successful treatment of severe neurological and cardiovascular abnormalities in a dog following ingestion of the neuropsychotropic drug, phenibut.Case SummaryA 2‐year‐old neutered male Weimaraner was found unresponsive and laterally recumbent in his urine after ingesting approximately 1600 mg/kg of phenibut. On presentation to an emergency clinic, the dog was neurologically inappropriate, tachycardic, hypertensive, and exhibiting a profoundly decreased respiratory rate. Because of progressive clinical signs, electrolyte abnormalities, increased hepatic enzyme activity and bilirubin concentrations, and the development of pigmenturia, referral to specialist care was sought. On presentation, the dog was intermittently somnolent and then maniacal. Sinus tachycardia persisted, and hyperthermia was documented. Hospitalization for supportive care was undertaken, and the dog was administered IV fluids, flumazenil, antiepileptics, and IV lipid emulsion therapy. The dog developed hypoglycemia and treated with dextrose supplementation. Progressive increases in liver enzyme activities as well as pronounced increase in creatine kinase activity, consistent with rhabdomyolysis, were noted. Over the course of 48 hours, the hypoglycemia resolved, and clinical signs significantly improved. Ultimately, the dog was discharged with improved clinical signs, with the owner reporting that 1 week after discharge, a full recovery had been made, and no residual clinical signs persisted.New Information ProvidedTo the authors’ knowledge, there are no previous reports of phenibut intoxication in small animals. The growing availability and use of this drug by people in the past several years highlight the need for a greater understanding of its effects in companion animals.
Tools measuring high haptic fidelity of procedural skills trainers in physician training and education: a scoping review protocol
Authors: Kriener Kyleigh , Ding-Farrington Cameron , Rodgers Sarah , Midwinter Mark 
Published: July 2023

Objective:
The objective of this scoping review is to identify instruments that measure the physical haptic fidelity of procedural skills trainers.

Introduction:
Procedural skills trainers have demonstrated beneficial outcomes for clinicians when used to practice and rehearse procedures. Despite this, several design flaws currently limit the widespread implementation of such trainers. One notable deficit in current trainer designs is haptic fidelity. Identifying measurements of haptic fidelity may maximize the benefit of using certain training devices as well as guiding future design.

Inclusion criteria:
This review will consider studies that assess the high fidelity haptics of procedural skills training devices in adult physicians above the level of an intern physician. Studies that do not include physicians will be excluded.

Methods:
The review will follow the JBI methodology for scoping reviews and will be reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Both published and unpublished studies will be searched for in MEDLINE (PubMed), Scopus, Web of Science Core Collection, Cochrane Central Register of Controlled Trials (CENTRAL), Embase (Ovid), CINAHL (EBSCOhost), ProQuest Dissertations and Theses (ProQuest), and Google Scholar. There will be no date, setting, or geographical limits and only studies in English will be included.

Review Registration Number:
Open Science Framework: https://osf.io/pvazu/
Percepción de la simulación clínica como experiencia de aprendizaje en estudiantes de Licenciatura en Enfermería
Authors: Garza Hernández Rosalinda , Meléndez Méndez Ma. Concepción , González Salinas Juana Fernanda , Rangel Torres Ma. del Socorro , Castañeda Hidalgo Hortensia , Sánchez Castellanos Erika 
Published: July 2023

Introducción: La simulación clínica es una herramienta de aprendizaje que integra conocimiento, destreza, participación y compromiso del estudiante, permite la reproducción, retroalimentación, valoración y reflexión, significa una oportunidad para generar competencias que favorezcan la formación de un pensamiento crítico, razonamiento y juicio clínico, habilidades de comunicación, de trabajo en equipo, resolución de problemas y toma de decisiones. Objetivo: Identificar la percepción de los estudiantes de la licenciatura de enfermería hacia la simulación clínica como experiencia de aprendizaje en una institución pública universitaria en el noreste de México. Metodología: Enfoque cuantitativo, diseño descriptivo y transversal, en 477 estudiantes de enfermería, se utilizó el cuestionario “Percepción de los estudiantes de enfermería respecto a la simulación clínica como experiencia de aprendizaje”. Se consideraron aspectos éticos normativos establecidos en México. Resultados: La percepción de los estudiantes acerca de la simulación clínica como herramienta de aprendizaje fue muy buena en un 49.5%, buena un 44.9%, lo que indica que fue una experiencia positiva. Conclusiones: la percepción de la simulación clínica como experiencia de aprendizaje mostrada por los estudiantes fue positiva. fortaleció la actitud para trabajar en equipo, liderazgo, comunicación, integrar la teoría y generar un pensamiento crítico.
Palabras claves: Entrenamiento simulado, aprendizaje, estudiante de enfermería.
Timing of carbon uptake by oceanic crust determined by rock reactivity
Authors: Albers Elmar , Jöns Svenja , Gerdes Axel , Klügel Andreas , Beier Christoph , Kasemann Simone A. , Bach Wolfgang 
Published: July 2023

Abstract
Carbonate formation during the alteration of oceanic crust is a global CO2 sink. Its timing and controls are not well understood, particularly in volcanic seamounts, which react with seawater over tens of millions of years. We report in situ U-Pb age dates of carbonate vein and void fill in 50–74 Ma basaltic basement of the Louisville Seamount Chain. More than 90% of the carbonate formed &lt;20 m.y. after seamount emplacement. Vesicle carbonate precipitated within 8 m.y. (median = 2.9 m.y.) whereas vein carbonate grew over longer time spans (median = 8.1 m.y.). The duration of carbonation was hence limited despite the basement’s long-term exposure to seawater. The age dates imply a rapid infill of vesicles by alteration of confined domains around vesicles. Carbonate formation in veins extended for longer periods of time, likely due to the late opening of fractures, which exposed fresh reactive rock surface to circulating seawater long after the formation of the basement.
We suggest that carbonate growth ceased after the volcanic rocks were too altered to liberate sufficient Ca2+ and generate the alkalinity required for carbonate precipitation. A critical extent of rock reactivity is required to sustain carbonate formation. Carbonate precipitation likely ends after much of the exposed basaltic substrate has been altered and the rock reactivity drops below this critical threshold. These findings help to explain the generally short duration of carbonation in the flanks of mid-ocean ridges.
Osteogenesis imperfecta type VIII: highlighting the need for genetic testing
Authors: Mariki Haika , Muze Kandi , Mussa Fatima , Manji Karim Premji 
Published: July 2023

We report a severe form of osteogenesis imperfecta (OI) type VIII from a lower-middle income country. This is the first case report of this type in Tanzania. The term neonate was delivered normally via spontaneous vaginal delivery and presented at the neonatal unit with features of shortened limb girdles and macrocephaly. The long bones had multiple fractures. He was diagnosed clinically to have OI or a type of metaphysial dysplasia. A plain X-ray showed multiple fractures of the long bones. The eyes did not have blue sclerae. Clinically, the generic diagnosis of OI was made.Genetic testing revealed typical prolyl 3-hydroxylase 1 (P3HI) gene mutations and a variant coordinateNM_001243246.1:c.1095C>G p, indicating a severe, fatal form of autosomal-recessive OI type VIII which presents with white sclerae. This rare variant is described here for the first time in our setting. This case highlights the need for genetic testing.
Severe allergic systemic reaction to personal protective equipment during the COVID-19 pandemic
Authors: Italiano Pasquale Filippo , Krummenacher Matthew , Lucas Michaela 
Published: July 2023

Our case describes a hospital worker who suffered a severe reaction to personal protective equipment (PPE) during the COVID-19 pandemic. After researching the excipient list of her PPE and completing a literature review, we postulated that isocyanates used in the production of the polyurethane band of the N95 mask was the cause for her reaction. In the absence of standardised testing, we tested this hypothesis by replicating her reaction to PPE by using a commercially available isocyanate patch, identifying diphenylmethane-4, 4-diisocyanate as the culprit agent.We recommended caution in the use of polyurethane containing N95 masks- for people reporting allergic reaction- and testing for sensitivity for polyurethane. The patient was able to tolerate non-polyurethane containing standard surgical masks, providing an option for PPE in some clinical circumstances. Since avoiding N95 masks, she has not had any further reactions.
Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation
Authors: Di Fazio Pietro , Mielke Sophia , Böhm Isabell T , Buchholz Malte , Matrood Sami , Schuppan Detlef , Wissniowski Thaddeus 
Published: July 2023

ObjectiveStellate cells are responsible for liver and pancreas fibrosis and strictly correlate with tumourigenesis. Although their activation is reversible, an exacerbated signalling triggers chronic fibrosis. Toll-like receptors (TLRs) modulate stellate cells transition. TLR5 transduces the signal deriving by the binding to bacterial flagellin from invading mobile bacteria.DesignHuman hepatic and pancreatic stellate cells were activated by the administration of transforming growth factor-beta (TGF-β). TLR5 was transiently knocked down by short-interference RNA transfection. Reverse Transcription-quantitativePCR and western blot were performed to analyse the transcript and protein level of TLR5 and the transition players. Fluorescence microscopy was performed to identify these targets in spheroids and in the sections of murine fibrotic liver.ResultsTGF-β-activated human hepatic and pancreatic stellate cells showed an increase ofTLR5expression.TLR5knockdown blocked the activation of those stellate cells. Furthermore, TLR5 busted during murine liver fibrosis and co-localised with the inducible Collagen I. Flagellin suppressedTLR5,COL1A1andACTA2expression after the administration of TGF-β. Instead, the antagonist of TLR5 did not block the effect of TGF-β. Wortmannin, a specific AKT inhibitor, inducedTLR5but notCOL1A1andACTA2transcript and protein level.ConclusionTGF-β-mediated activation of hepatic and pancreatic stellate cells requires the over-expression of TLR5. Instead, its autonomous signalling inhibits the activation of the stellate cells, thus prompting a signalling through different regulatory pathways.
Estimating the prevalence of poor-quality anti-TB medicines: a neglected risk for global TB control and resistance
Authors: Tabernero Patricia , Newton Paul N 
Published: July 2023

ObjectivesTuberculosis (TB) remains a major global public health problem, especially with the recent emergence of multidrug-resistant TB and extensively drug-resistant TB. There has been little consideration of the extent of substandard and falsified (SF) TB medicines as drivers of resistance. We assessed the evidence on the prevalence of SF anti-TB medicines and discussed their public health impact.Materials/methodsWe searched Web of Science, Medline, Pubmed, Google Scholar, WHO, US Pharmacopeia and Medicines Regulatory Agencies websites for publications on anti-TB medicines quality up to 31 October 2021. Publications reporting on the prevalence of SF anti-TB drugs were evaluated for quantitative analysis.ResultsOf the 530 screened publications, 162 (30.6%) were relevant to anti-TB medicines quality; of those, 65 (40.1%) described one or more TB quality surveys in a specific location or region with enough information to yield an estimate of the local prevalence of poor-quality TB medicines. 7682 samples were collected in 22 countries and of those, 1170 (15.2%) failed at least one quality test. 14.1% (879/6255) of samples failed in quality surveys, 12.5% (136/1086) in bioequivalence studies and 36.9% (87/236) in accelerated biostability studies. The most frequently assessed were rifampicin monotherapy (45 studies, 19.5%) and isoniazid monotherapy (33, 14.3%), rifampicin-isoniazid-pyrazinamide-ethambutol fixed dose combinations (28, 12.1%) and rifampicin-isoniazid (20, 8.6%). The median (IQR) number of samples collected per study was 12 (1–478).ConclusionsSF, especially substandard, anti-TB medicines are present worldwide. However, TB medicine quality data are few and are therefore not generalisable that 15.2% of global anti-TB medicine supply is SF. The evidence available suggests that the surveillance of the quality of TB medicines needs to be an integral part of treatment programmes. More research is needed on the development and evaluation of rapid, affordable and accurate portable devices to empower pharmacy inspectors to screen for anti-TB medicines.
Patientsrequestingandreceivingeuthanasia for psychiatric disorders in the Netherlands
Authors: Kammeraat Monique , van Rooijen Geeske , Kuijper Lisette , Kiverstein Julian D , Denys Damiaan A J P 
Published: July 2023

BackgroundEuthanasia and assisted suicide (EAS) for patients with psychiatric disorders occupies a prominent place in the public debate, but little is known about the psychiatric patients requesting and receiving EAS.ObjectiveTo compare the social demographic and psychiatric profile of the patients who make a request for EAS and those who receive it.MethodWe carried out a review of records from 1122 patients with psychiatric disorders who have filed a potentially eligible request for EAS at Expertise Centrum for Euthanasia (EE) in the period 2012–2018.FindingsThe majority of the patients requesting EAS were single females, living independently with a comorbid diagnosis of depression with a history of undergoing psychiatric treatment for more than 10 years. From the small number of patients who went on to receive EAS in our sample, the majority were also single women, with a diagnosis of depressive disorder. A small subgroup of patients whose diagnoses included somatic disorders, anxiety disorders, obsessive-compulsive disorders and neurocognitive disorders were over-represented in the group of patients receiving EAS compared with the applicant group.ConclusionThe average demographic and psychiatric profile of patients requesting and receiving EAS were found to be broadly similar. The majority of patients requesting EAS had received a comorbid diagnosis, making this a difficult-to-treat patient group. Only a small number of patients requesting had their requests granted. Patients from different diagnostic groups showed patterns in why their requests were not granted.Clinical implicationsMany of the patients who withdrew their requests for EAS benefited from being able to discuss dying with end of life experts at EE. Health professionals can make a difference to a vulnerable group of patients, if they are trained to discuss end of life.
Anatomical distribution and clinical significance of middle cerebral artery M2 segment vessel occlusions and its cortical branches in acute ischaemic stroke patients
Authors: Gruber Philipp , Valbuena Paola , Sassenburg Renske , Anon Javier , Andereggen Lukas , Berberat Jatta , Remonda Luca 
Published: July 2023

BackgroundCharacterisation of anatomical distribution and the clinical impact of middle cerebral artery M2 (MCA-M2) segment occlusion and its subsequent cortical branches (CBs) in acute ischaemic stroke patients (AIS).MethodsRetrospective, monocentric study analysing radiological and clinical data of AIS patients with MCA-M2 segment occlusion with regard to the anatomic distribution of MCA-M2 occlusion and its subsequent CB.ResultsA total of 203 patients (median age 77 (IQR 66–83) years, 112 women) were included. There was an equal distribution of right-sided versus left-sided MCA-M2 vessel occlusions (right: n=97; left: n=106), as well as with a median number of affected MCA-M2 CBs of 4 (IQR, 3–6) and a median National Institute of Health Stroke Scale score (NIHSS) on admission of 9 (3–15). For both hemispheres, CBs of the inferior trunks were significantly more affected than the superior trunks. Endovascular treatment (EVT, n=94) was associated with a significant better outcome compared with patients with medical management alone (p=0.027).ConclusionIn acute MCA-M2 segment occlusions, inferior trunks are significantly more affected compared with the superior trunks. The subsequent CBs of the paracentral region of both hemispheres are more commonly involved. In eloquent vascular territories, EVT was more often performed.
Role of optical coherence tomography in depression detection: a protocol of systematic review and meta-analysis
Authors: Xiao Xili , Zhong Dongling , Liu Huan , Fan Rong , Jiang Chengzhi , Zheng Zhong , Li Yuxi , Wan Li 
Published: July 2023

IntroductionOptical coherence tomography (OCT) is a non-invasive approach for detecting changes in the retinal layers, which may also reflect changes in brain structure and function. As one of the leading causes of disability worldwide, depression has been associated with alteration of brain neuroplasticity. However, the role of OCT measurements in detecting depression remains unknown. This study aims to employ a systematic review and meta-analysis approach to explore ocular biomarkers measured by OCT for detecting depression.Methods and analysisWe will search studies describing the relationship between OCT and depression across seven electronic databases, and retrieve articles published from database inception to date. We will also manually search grey literature and reference lists included in the retrieved studies. Two independent reviewers will screen studies, extract data and assess risk of bias. Target outcomes will include peripapillary retinal nerve fibre layer thickness, macular ganglion cell complex thickness and macular volume, as well as other related indicators. Next, we will conduct subgroup analysis and meta-regression to explore study heterogeneity, then perform sensitivity analysis to investigate the robustness of the synthesised results. Meta-analysis will be performed using Review Manager (V.5.4.1) and STATA (V.12.0), and the certainty of evidence will be graded according to the Grading of Recommendations Assessment, Development and Evaluation system.Ethics and disseminationEthics approval is not necessary because the data used in this systematic review and meta-analysis will be extracted from published studies. Study results will be disseminated by publishing our findings in a peer-reviewed journal.
Process evaluation in practice based research networks: a study protocol for a mixed-methods implementation study
Authors: Sanftenberg Linda , Dreischulte Tobias , Härdtlein Annette , Kosub Helena , Gagyor Ildiko , Kurotschka Peter Konstantin , Kühlein Thomas , Burggraf Larissa , Eck Stefanie , Roos Marco , Gensichen Jochen 
Published: July 2023

IntroductionGeneral practitioners often criticise clinical trials for their poor applicability in primary care, which may at least partially explain why their engagement in primary care research remains limited. In order to enhance primary care research, the German government has funded six regional practice based research networks (PBRNs). Within the Bavarian PBRN (BayFoNet), two cluster-randomised pilot trials will be conducted. This paper presents the protocol of the process evaluation accompanying both trials, which aims to explore relevance, feasibility, acceptability and credibility of clinical research in primary care from the perspectives of BayFoNet researchers, general practitioners, and patients.Methods and analysisThe BayFoNet will be established by recruiting general practices (GPs) as prospective research collaborators in two cluster randomised pilot trials. Research teams will provide training in good clinical practice, and support practices in patient recruitment, data collection and documentation. Our process evaluation explores barriers and facilitators in the set up of the BayFoNet PBRN and both cluster randomised pilot trials, under the application of the consolidated framework for implementation research and the theoretical domains framework. In a mixed-methods concept, we will use qualitative and quantitative approaches to evaluate both pilot cluster-randomised trials as well as the BayFoNet itself: focus groups with researchers, semi-structured interviews with general practitioners and questionnaires for patients participating in the pilot cluster-randomised trials at three different time points.Ethics and disseminationResearch ethical approval for this study was granted by the Ethics Committee of the Medical Department, Ludwig-Maximilians-University Munich (AZ 21-1135). Results will be published in international peer-reviewed journals and summaries will be provided to the funders of the study as well as other PBRNs, GP teams and patients.Trial registration numbersDRKS00028805,NCT05667207.