bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiproliferative Effect of Essential Oil Obtained from Oregano (Lippia palmeri S. Watson) Leaves Grown in Hydroponics and LED Light
Authors: Bringas‐Burgos Brando Fabián , Martínez‐Robinson Karla Guadalupe , Toledano‐Magaña Yanis , García‐Ramos Juan Carlos , Ovando‐Martínez Maribel , López‐Elías Jesús 
Published: February 2023

AbstractNowadays, light‐emitting diodes (LED) provide an alternative source to sunlight with specific intensity and wavelength that promotes plant growth. The features offered by LED could also stimulate the production of secondary metabolites of pharmaceutical interest. This work analyzed the cultivation of oregano (Lippia palmeri S. Watson) in a floating root hydroponic system supplemented by full‐spectrum LED artificial light. Growth indicators like height, diameter, number of shoots, and leaf length and width were measured. The essential oil (EO) composition from the leaves of wild and hydroponic conditions found thymol (41.8 %) as the main product for the former and carvacrol (47 %) in hydroponics. The antiproliferative activity of EOs on human colorectal cancer HCT‐15 shows that 6.4 μg/ml for hydroponic and 7.4 μg/ml for the wild plant reduce more than 50 % the cell viability. Overall, this study indicates that hydroponic conditions and full spectrum LED modifies the composition of the EO of L. palmeri on compared with the wild plant, which effectively induces cell growth inhibition in human colorectal cancer.
Impact of calcified nodule on target lesion failure after stent implantation in hemodialysis patients
Authors: Matsuhiro Yutaka , Nakamura Daisuke , Dohi Tomoharu , Ishihara Takayuki , Okamoto Naotaka , Mizote Isamu , Mano Toshiaki , Nishino Masami , Sakata Yasushi 
Published: February 2023

AbstractBackgroundLittle is known about intravascular imaging predictors of cardiac events after drug‐eluting stent (DES) implantation in hemodialysis (HD) patients. We aimed to reveal the association between calcified nodules (CN) and target lesion failure (TLF) in HD patients after DES implantation.MethodsWe enrolled 114 HD patients who underwent DES implantation between October 2016 and October 2020. The patients were divided into a CN group (39%, 44 patients) and a non‐CN group (61%, 70 patients). The primary endpoint was the incidence of TLF, including cardiac death, target vessel myocardial infarction, and clinically driven target lesion revascularization.ResultsHD duration was longer, and the calcium burden was higher in the CN group than in the non‐CN group. Over a median follow‐up of 607 days [interquartile range: 349–965 days], the cumulative incidence curve showed that the CN group had a significantly higher incidence of TLF than the non‐CN group (31.8% vs. 11.4% within 3 years, p = 0.008).　On Fine‐Gray sub‐distribution hazard model analysis, the CN group was associated with an increased rate of TLF (hazard ratio [HR]: 2.86; 95% confidence interval [CI]: 1.21–6.75, p = 0.016). An in‐stent CN was observed in 73% of the lesions with target lesion revascularization in the CN group, whereas no in‐stent CN was observed in the non‐CN group (p = 0.026).ConclusionsCN was an independent predictor of TLF in patients undergoing HD. In‐stent CN was an important cause of TLF after DES implantation in CN lesions in HD patients; therefore, a different strategy should be considered for treating the lesions.
A case of COVID‐19‐related necrotic nasal ulceration
Authors: Angelou Dimitrios , Calder Nicholas 
Published: February 2023

AbstractWe are reporting a case of a COVID‐19‐related necrotic nasal ulcer. All other common etiologies were excluded after a full round of investigations. Even though COVID‐19 has been known to cause skin ulcers via different mechanisms, this is the first nasal ulcer to be reported in the current literature.
Chemotherapy‐induced leukopenic septic shock treated with veno‐arterial extracorporeal membrane oxygenation: A case report
Authors: Hoshino Atsumi , Ichiba Shingo , Ishikawa Junya , Seino Yusuke , Yoshida Takuo , Sato Nobuo , Nomura Takeshi 
Published: February 2023

AbstractWe present a case of chemotherapy‐induced leukopenic septic shock treated with veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO). Although the indication for VA‐ECMO for septic shock in immunosuppressed states remains controversial, her relatively young age and a slightly increasing leukocyte count led to VA‐ECMO induction and resulted in recovery.
Decreasing tobacco use promotes ulcer healing in a patient with Buerger's disease
Authors: Jaroonwanichkul Sandra , Hall John C. 
Published: February 2023

AbstractTobacco cessation remains the mainstay treatment for Buerger's Disease; however, limited research exists examining the effect of decreased tobacco use rather than cessation in improving symptoms. We describe a case of a patient with Buerger's disease who experienced ulcer healing and pain improvement through reduced tobacco use.
CuCr Bimetallic Catalyst for Selective Electrooxidation of Ammonia at Room Temperature
Authors: Cleetus Annie , Teller Hanan , Schechter Alex 
Published: February 2023

AbstractIn an effort to attain a low‐cost, energy‐efficient, and non‐noble electro‐catalyst that selectively oxidises ammonia to nitrogen at room temperatures, bimetallic carbon‐supported CuxCry (x,y=1–9) catalysts were prepared and found to be more active than elemental Cu and Cr towards ammonia oxidation (AOR). Cyclic voltammetry (CV) measurements revealed an increase in activity with Cu content. Peak current density of 90 % Cu catalyst in 0.1 M KOH+0.1 M NH4OH was found to be 22 mA/mg (scan rate=20 mV/s) compared with 14.8 mA/mg for commercial Pt catalyst under the same conditions. Mass spectrometry measurements have identified higher selectivity of this catalyst towards N2 than on Cu alone. Pre‐oxidation of catalyst in 0.1 M KOH (1.1 V vs RHE) was found to improve the activity and stability towards AOR over time. The potential of CuxCry (x, y=1–9) based catalysts for AOR in fuel cells is corroborated.
Sunn hemp biomass accumulation, regrowth, and nutritive value in response to harvest time and cutting height
Authors: Shortnacy Lauren K. W. , Eberle Carrie , Paisley Steve 
Published: February 2023

AbstractThe integrated crop‐livestock systems of the northern High Plains are lacking in annual legumes that meet the nutrient demands of beef cattle when alfalfa (Medicago sativa) is in limited supply. We investigated the biomass accumulation, regrowth biomass, and nutritive value of sunn hemp (Crotalaria juncea) in response to initial harvest day and cutting height in irrigated and dryland studies in Wyoming. Net biomass accumulations in 105‐day growing period were 4.4 tons acre−1 under irrigation and 0.7 tons acre−1 in dryland conditions. Initial harvest day after planting (iDAP) affected initial and regrowth biomass accumulation but did not affect net biomass accumulation in irrigated or dryland studies. Regrowth and net biomass accumulations were affected by cutting height in the irrigated study only. Nutritive value concentrations were significantly affected by iDAP in both irrigated and dryland studies. Under irrigation, net nutrient accumulation was not affected by iDAP but was significantly greater with a cutting height of 4.2 inches compared to 2.5‐ and 6‐inch heights. In contrast, the dryland study, net nutrient accumulation was not affected by cutting height but was higher in 55–105 iDAP than 45 iDAP. In the irrigated study, a cutting height of 4.2 inches produced net accumulations higher in both biomass accumulation and nutritive value. In the dryland study a harvest time of 55–105 iDAP produced the highest net accumulation regardless of harvest time or cutting height. Sunn hemp can be harvested once or twice in a 105‐day growing season to produce biomass and essential nutrients for livestock feeding.
Engineering TM1459 for Stabilisation against Inactivation by Amino Acid Oxidation
Authors: Grill Birgit , Pavkov-Keller Tea , Grininger Christoph , Darnhofer Barbara , Gruber Karl , Hall Mélanie , Schwab Helmut , Steiner Kerstin 
Published: February 2023

AbstractOxidative alkene cleavage is a highly interesting reaction to obtain aldehydes and ketones. The Mn‐dependent protein TM1459 from Thermotoga maritima can catalyse alkene cleavage of styrene derivatives in the presence of tert‐butyl hydroperoxide. Despite the high thermal stability of the enzyme, it gets inactivated during the reaction. The data reported here indicate that auto‐oxidation is responsible for the low stability of TM1459 in the oxidative environment required for the alkene cleavage reaction. By targeting the exchange of residues prone to oxidation, this phenomenon was successfully prevented. Importantly, the stability to oxidation conveyed by the amino acid exchanges led to increased enzyme activity. However, the exchanges resulted in slightly modified positions of two of the four metal‐binding amino acids, thereby strongly impacting metal binding.
Safety, efficacy, and pharmacokinetics of SH‐1028 in EGFR T790M‐positive advanced non–small cell lung cancer patients: A dose‐escalation phase 1 study
Authors: He Jing , Ma Pei , Zhao Dongmei , Shi Xinsheng , Guo Renhua , Gao Wen , Shu Yongqian 
Published: February 2023

AbstractBackgroundSH‐1028 is a new third‐generation EGFR tyrosine kinase inhibitors (TKI) to benefit patients with EGFR T790M‐mutated NSCLC. Here, the authors report its clinical safety, preliminary efficacy, and pharmacokinetic (PK) profile for the first time.MethodsPatients with EGFR T790M mutation, locally advanced non–small cell lung cancer (NSCLC), or metastatic NSCLC who had progressed after previous EGFR TKI therapy were eligible. Patients received SH‐1028 at five oral dose levels (60 mg, 100 mg, 200 mg, 300 mg, and 400 mg) once daily until disease progression, unacceptable toxicity, or patient withdrawal. The primary end points were the safety, dose‐limiting toxicity (DLT), maximum‐tolerated dose (MTD), and PK profile. Secondary end points included objective response rate (ORR), disease control rate (DCR), progression‐free survival (PFS), etc.ResultsData cut off on December 31, 2020, a total of 20 patients were enrolled during the trial, two of three patients in 300 mg cohort experienced a DLT, and no DLT was observed in 240 mg cohort, 240 mg was determined to be the MTD of SH‐1028. A total of 95.0% (19 of 20) of patients reported treatment‐related adverse events (TRAEs), and the incidence of serious adverse events was 20.0% (4 of 20). The ORR and DCR of the 200 mg cohort were 75% (95% confidence interval [CI], 19.41–99.37) and 75.0% (95% CI, 19.41–99.37), respectively. The overall ORR was 40% (95% CI, 19.12–63.95), and DCR was 70.0% (95% CI, 45.72–88.11). According to the PK profile, the dosage regimen for future studies was determined as 200 mg once daily.ConclusionsSH‐1028 showed a manageable safety and promising antitumor activity in patients with EGFR T790M mutation at the dose of 200 mg once daily.Plain language summary

Lung cancer has a high morbidity and mortality, with an estimated 1.8 million deaths in 2020. Non–small cell lung cancer accounts for approximately 85% of lung cancer.

First‐ or second‐generation EGFR TKIs' weak selectivity often led to the occurrence of treatment‐related adverse events, such as interstitial lung disease, rash, diarrhea, etc., along with acquired drug resistance within approximately 1 year.

A dose of 200 mg of SH‐1028 once daily showed a preliminary antitumor activity with manageable safety in patients with EGFR T790M mutation.
Associations of the activity and concentration of carbonic anhydrase VI with susceptibility to dental caries: A systematic review and meta‐analysis
Authors: Al‐Mahdi Rania , Al‐Sharani Hesham , Al‐Haroni Mohammed , Halboub Esam 
Published: February 2023

AbstractObjectivesA number of studies have claimed that carbonic anhydrase VI (CA VI) is associated with dental caries. The aim of this systematic review and meta‐analysis was to systematically review and analyze the literature on the association of CA VI (in terms of concentration and activity) with dental caries.Materials and MethodsA systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Relevant search terms were employed to search the following databases: PubMed, Web of Science, Scopus, China National Knowledge Infrastructure (CNKI), and Cochrane Library databases. Eligible publications from inception to August 2022 were included. The relevant records were assessed independently by two reviewers, and a meta‐analysis was performed using RevMan 5.3.ResultsOut of 237 relevant records from the initial search, 9 met the criteria for this review. The 9 papers, including 477 participants, were qualitatively analyzed. Seven studies with 411 participants (203 caries‐free) were included in the meta‐analysis on CA VI activity, and 2 studies with 141 participants (71 caries‐free) were included in the meta‐analysis on CA VI concentration. The results showed that CA VI activity was significantly higher among participants with caries than their caries‐free counterparts (standardized mean difference (SMD) = 0.894, 95% confidence interval (CI95%): 0.386 and 1.392; p < 0.001), whereas the CA VI concentration was significantly lower among participants with caries than their caries‐free counterparts (SMD = −0.672, CI95%: −1.011 and −0.332; p < 0.001).ConclusionsThis meta‐analysis of a relatively small number of studies suggests that the CA VI concentration is lower and CA VI activity is higher in patients with dental caries than in caries‐free individuals; however, further studies are needed to determine the exact role of CA VI in dental caries.
Growth, yield productivity, and oil composition of two Amaranthus species grown under two different environmental conditions in Egypt
Authors: El‐Gendy Abdel Nasser G. , Pistelli Laura , Omer Elsayed A. , Elsayed Shaimaa I. M. , Elshamy Abdelsamed I. , Hendawy Saber F. 
Published: February 2023

AbstractAmaranthus plants are very rich in nutritional benefits with significant traditional uses especially against inflammations. Herein, the growth productivity, oil quality, and compositions of the two promising novel food resources, Amaranthus caudatus and Amaranthus tricolor, were evaluated in two different locations in Egypt (El‐Sharkia and El‐Minia) which have different geographical regions. Analyses of geographic positions, climatic data, and soil characteristics of the two locations were evaluated. Plant heights, number of branches/plant, seed yield, and inflorescence length of the two plant species were studied in both locations. Additionally, the seed oil yields along with their gas chromatography–mass spectroscopy (GC–MS) profiles were characterized. The findings revealed a significant difference between the two locations, with a strong correlation between the yields and the climate conditions. The two plant species cultivated in El‐Minia showed significant records of overall growth indicators than El‐Sharkia. A worthy variability in the oil yields and composition of El‐Minia samples exhibited higher contents of dry matter in both plants (89.01 and 89.03 g/100 g dry tissues, respectively) than those of El‐Sharkia. Amaranthus caudatus cultivated in El‐Sharkia showed higher lipids components (7.02 g/100 g dry seeds) and saturated (19.13 g/100 g dry seeds) and unsaturated fatty acids (61.32 g/100 g) than those of El‐Minia site. In addition, A. tricolor cultivated in El‐Sharkia contained higher lipids contents (6.87 g/100 g) and unsaturated fatty acids (61.75 g/100 g dry seeds) than El‐Minia with the supremacy of El‐Minia samples in saturated fatty acids (19.03 g/100 g dry seeds). A strong correlation between the lipids and fatty acids of A. caudatus and A. tricolor was determined, and the cultivation locations and conditions were found based upon the GC–MS analysis as well as statistical significance.
Synthesis of ONO‐Ligated Tetrylenes Based on 2,6‐bis(2‐Hydroxyphenyl)pyridines: Influence of Ligand Sterics on the Structure of the Products
Authors: Mankaev Badma N. , Serova Valeriia A. , Syroeshkin Mikhail A. , Akyeva Anna Ya. , Sobolev Alexey V. , Churakov Andrei V. , Lermontova Elmira Kh. , Minyaev Mikhail E. , Oprunenko Yury F. , Zabalov Maxim V. , Zaitsev Kirill V. , Zaitseva Galina S. , Karlov Sergey S. 
Published: February 2023

AbstractA series of novel tetrylenes based on three 2,6‐bis(2‐hydroxyphenyl)pyridines 4 a–4 c have been obtained by the reaction of Lappert's tetrylenes E[N(SiMe3)2]2 (E=Ge, Sn) with corresponding tridentate pyridine‐linked phenol‐based ligands. It was found that the structure of the ligand and the size of the atom of the group 14 element drastically affect the structure of the reaction product. Ligand 4 c with a bulky tert‐butyl group leads to monomeric tetrylenes, while ligands with less bulky groups lead to bis‐ligand derivatives of M(IV) (M=Ge, Sn) and a coordination polymer. Also, derivatives of germanium (IV) and tin (IV) were obtained by the metathesis reaction of MCl4 (M=Ge, Sn) with lithium phenoxides. The compositions and structures of the novel compounds were established by elemental analysis and 1H, 13C, 119Sn (5–7), 1H DOSY (6) NMR spectroscopy, in the solid state by X‐ray diffraction analysis (germylene 10, stannylene 6, Ge4+ compound 8, Sn4+ compound 7) and 119Sn Mössbauer spectrum of tin complex 6. All the synthesized tetrylenes are monomeric. Tetrylenes 6 and 10 were characterized by cyclic voltammetry. A study of the redox behavior of 6, 10 by cyclic voltammetry on a glassy carbon working electrode in acetonitrile solution of 0.1 M Bu4NPF6 as a supporting electrolyte showed that these compounds can be both oxidized and reduced electrochemically in the accessible potential range.
Regiodivergent Synthesis of 11H‐Indolo[3,2‐c]quinolines and Neocryptolepine from a Common Starting Material
Authors: Håheim Katja S. , Lund Bjarte Aarmo , Sydnes Magne O. 
Published: February 2023

AbstractA large number of diversely functionalized analogs of the bioactive natural products neocryptolepine and isocryptolepine have been prepared from a series of 3‐bromoquinoline derivatives. The neocryptolepines were obtained by a Pd0‐catalyzed C−C bond coupling followed by C−N bond formation in yields up to 80 %, whereas the indoloquinolines were prepared by a Suzuki‐Miyaura cross‐coupling followed by azidation‐photochemical cyclization in yields ranging from traces to 95 % yield.
Enhancement of thermal properties of Al/MoO3 thermite by electrostatic spraying
Authors: Chen Jialin , Li Shutao , Chen Du , Gao Lin , Chen Yeqing , Song Jiaxing 
Published: February 2023

AbstractTo improve the thermal properties of thermite safely and stably, electrostatic spraying was used to prepare the Al/MoO3 thermite. The Al/MoO3 thermites were detected and characterized by scanning electron microscopy (SEM) and X‐ray diffraction (XRD), and thermal decomposition experiments were carried out by differential scanning calorimetry (DSC). The heat release of the Al/MoO3 thermite prepared by the electrostatic spray (1044 J g−1) is significantly higher than that of the thermite prepared by the ultrasonic (692 J g−1), which is due to more uniform dispersion between Al and MoO3. The initial reaction temperature and activation energy (Ea) of the former keep it steady. Electrostatic spray ensures the safety and stability of the Al/MoO3 thermite. This study provides a new idea for safely and stably improving the thermal properties of thermite by enhancing surface homogenization, which is of great significance for practical applications.
Low temperature sintering lead‐free dielectric xBiScO3‐(1‐x)BaTiO3 for energy storage applications
Authors: Joseph Jincymol , Du Yumeng , Cheng Zhenxiang , Zhang Shujun 
Published: February 2023

AbstractFabrication of ceramic capacitors requires technological breakthroughs to address growing concerns regarding sustainability, cost, and increased power consumption in the manufacturing process. Low temperature sintered xBiScO3‐(1‐x)BaTiO3 (BS‐BT) with x = 0.4 is found to possess excellent energy storage performance and temperature stability. The grain size decreases from 3.5 μm sintered at 1100°C to less than 0.5 μm sintered at 800°C, leading to much improved breakdown field and energy storage properties. Recoverable energy density of 4.7 J/cm3 with a high efficiency of 89% was obtained at an electric field of 390 kV/cm, showing an excellent temperature stability over temperature range of 25–200°C and fatigue endurance for more than 105 cycles. Of particular importance is that the ceramic tape cofired with silver electrode over temperature range of 800–850°C shows no reaction and diffusion of silver at the electrode/ceramic interface, while a recoverable energy density of 3.3 J/cm3 was achieved with satisfactory efficiency of 80% at an electric field of 340 kV/cm when sintered in reduced atmosphere, expanding the electrode selection to low‐cost base metal, such as Cu and Ni. This work provides a good paradigm in ceramic capacitor fabrications that will help reduce overall cost and power consumption by utilizing low temperature sintered lead‐free dielectrics with comparable or even superior energy storage properties over state‐of‐the‐art dielectrics.image
Efficient regional seismic risk assessment via deep generative learning of surrogate models
Authors: Li Shanwu , Farrar Charles , Yang Yongchao 
Published: February 2023

AbstractEfficient regional seismic risk assessment including ground motion prediction and damage risk estimation is needed for emergency response planning. However, a conventional regional assessment suffers from low data‐ and time‐ efficiency as it generally involves a large number of locations and infrastructure systems that have specific soil conditions, and geometric, material, and structural properties, requiring access to large data and massive individual calculations with complicated procedures. To achieve efficient regional seismic risk assessment, this work presents a deep generative learning framework to construct input–output surrogate models of regional seismic risk by learning the underlying complex relation between earthquake source parameters and regional seismic risk involving many locations and structures from data. The learned deep surrogate models directly output the ground motion intensity map and the risk map of a region given earthquake source parameters, circumventing massive individual calculations and data access to individual locations and structures. The presented framework is validated on the bridge network risk assessment using simulated scenario earthquakes of the San Francisco Bay Area. We observe that the obtained deep surrogate models perform well without the need of data access to locations and structures and are time‐efficient. We also discuss the applicability and limitations of the presented framework.
An interpretable BRB model with interval optimization strategy for lithium battery capacity prediction
Authors: Han Peng , Zhao Boying , He Wei , Kong Lingkai , Li Yingmei , Zhou Guohui , Feng Junchen 
Published: February 2023

AbstractAccurately predicting the capacity of lithium battery is conducive to improving its safety. Affected by complex internal electrochemical reaction and external use conditions, the prediction accuracy is difficult to guarantee; at the same time, the existing prediction methods are unexplainable, resulting in the inability to trace the prediction process. Therefore, a capacity prediction model based on belief rule base with interpretability and interval optimization strategy is proposed in this paper. First, the reasoning process is designed according to interpretability modeling criteria. Second, to achieve a balance of accuracy and interpretability, based on the whale optimization algorithm, a model parameter optimization method using interval optimization strategy is proposed. Finally, through a case study, the model's effectiveness is verified. Comparison with other models shows that the proposed model has certain advantages in accuracy and interpretability.