bluuebunny/crossref_metadata_2025_split huggingface dataset:
When People With Chronic Conditions Turn to Peers on Social Media to Obtain and Share Information: Systematic Review of the Implications for Relationships With Health Care Professionals
Authors: Kjærulff Emilie Mølholm , Andersen Tue Helms , Kingod Natasja , Nexø Mette Andersen 
Published: January 2023

Background
People living with chronic conditions such as diabetes turn to peers on social media to obtain and share information. Although social media use has grown dramatically in the past decade, little is known about its implications for the relationships between people with chronic conditions and health care professionals (HCPs).

Objective
We aimed to systematically review the content and quality of studies examining what the retrieval and sharing of information by people with chronic conditions on social media implies for their relationships with HCPs.

Methods
We conducted a search of studies in MEDLINE (Ovid), Embase (Ovid), PsycINFO (Ovid), and CINAHL (EBSCO). Eligible studies were primary studies; examined social media use; included adults with any type of diabetes, cardiovascular diseases that are closely linked with diabetes, obesity, hypertension, or dyslipidemia; and reported on the implications for people with chronic conditions–HCP relationships when people with chronic conditions access and share information on social media. We used the Mixed Methods Appraisal Tool version 2018 to assess the quality of the studies, and the included studies were narratively synthesized.

Results
Of the 3111 screened studies, 17 (0.55%) were included. Most studies (13/17, 76%) were of low quality. The narrative synthesis identified implications for people with chronic conditions–HCP relationships when people with chronic conditions access and share information on social media, divided into 3 main categories with 7 subcategories. These categories of implications address how the peer interactions of people with chronic conditions on social media can influence their communication with HCPs, how people with chronic conditions discuss advice and medical information from HCPs on social media, and how relationships with HCPs are discussed by people with chronic conditions on social media. The implications are illustrated collectively in a conceptual model.

Conclusions
More evidence is needed to draw conclusions, but the findings indicate that the peer interactions of people with chronic conditions on social media are implicated in the ways in which people with chronic conditions equip themselves for clinical consultations, evaluate the information and advice provided by HCPs, and manage their relationships with HCPs. Future populations with chronic conditions will be raised in a digital world, and social media will likely remain a strategy for obtaining support and information. However, the generally low quality of the studies included in this review points to the relatively immature state of research exploring social media and its implications for people with chronic conditions–HCP relationships. Better study designs and methods for conducting research on social media are needed to generate robust evidence.
Parent-Reported Use of Pediatric Primary Care Telemedicine: Survey Study
Authors: Ray Kristin N , Wittman Samuel R , Burns Sarah , Doan Tran T , Schweiberger Kelsey A , Yabes Jonathan G , Hanmer Janel , Krishnamurti Tamar 
Published: January 2023

Background
Telemedicine delivered from primary care practices became widely available for children during the COVID-19 pandemic.

Objective
Focusing on children with a usual source of care, we aimed to examine factors associated with use of primary care telemedicine.

Methods
In February 2022, we surveyed parents of children aged ≤17 years on the AmeriSpeak panel, a probability-based panel of representative US households, about their children’s telemedicine use. We first compared sociodemographic factors among respondents who did and did not report a usual source of care for their children. Among those reporting a usual source of care, we used Rao-Scott F tests to examine factors associated with parent-reported use versus nonuse of primary care telemedicine for their children.

Results
Of 1206 respondents, 1054 reported a usual source of care for their children. Of these respondents, 301 of 1054 (weighted percentage 28%) reported primary care telemedicine visits for their children. Factors associated with primary care telemedicine use versus nonuse included having a child with a chronic medical condition (87/301, weighted percentage 27% vs 113/753, 15%, respectively; P=.002), metropolitan residence (262/301, weighted percentage 88% vs 598/753, 78%, respectively; P=.004), greater internet connectivity concerns (60/301, weighted percentage 24% vs 116/753, 16%, respectively; P=.05), and greater health literacy (285/301, weighted percentage 96% vs 693/753, 91%, respectively; P=.005).

Conclusions
In a national sample of respondents with a usual source of care for their children, approximately one-quarter reported use of primary care telemedicine for their children as of 2022. Equitable access to primary care telemedicine may be enhanced by promoting access to primary care, sustaining payment for primary care telemedicine, addressing barriers in nonmetropolitan practices, and designing for lower health-literacy populations.
An Algorithm to Classify Real-World Ambulatory Status From a Wearable Device Using Multimodal and Demographically Diverse Data: Validation Study
Authors: Popham Sara , Burq Maximilien , Rainaldi Erin E , Shin Sooyoon , Dunn Jessilyn , Kapur Ritu 
Published: January 2023

Background
Measuring the amount of physical activity and its patterns using wearable sensor technology in real-world settings can provide critical insights into health status.

Objective
This study’s aim was to develop and evaluate the analytical validity and transdemographic generalizability of an algorithm that classifies binary ambulatory status (yes or no) on the accelerometer signal from wrist-worn biometric monitoring technology.

Methods
Biometric monitoring technology algorithm validation traditionally relies on large numbers of self-reported labels or on periods of high-resolution monitoring with reference devices. We used both methods on data collected from 2 distinct studies for algorithm training and testing, one with precise ground-truth labels from a reference device (n=75) and the second with participant-reported ground-truth labels from a more diverse, larger sample (n=1691); in total, we collected data from 16.7 million 10-second epochs. We trained a neural network on a combined data set and measured performance in multiple held-out testing data sets, overall and in demographically stratified subgroups.

Results
The algorithm was accurate at classifying ambulatory status in 10-second epochs (area under the curve 0.938; 95% CI 0.921-0.958) and on daily aggregate metrics (daily mean absolute percentage error 18%; 95% CI 15%-20%) without significant performance differences across subgroups.

Conclusions
Our algorithm can accurately classify ambulatory status with a wrist-worn device in real-world settings with generalizability across demographic subgroups. The validated algorithm can effectively quantify users’ walking activity and help researchers gain insights on users’ health status.
Self-reported concussion history among midwestern skiers and snowboarders
Authors: Ivancich Marko , Berry Vince , Clark Michael , Beaumont Andrew , Norrbom Corina , Amundson Jeffrey C 
Published: January 2023

Aim: To assess the rate of self-reported concussion in midwestern skiers and snowboarders. Patients: Recreational skiers and snowboarders between the ages of 14 and 69 years during a single winter ski season (2020–2021) at a ski area in Wisconsin, USA. Methods: Survey study. Results: Among this survey population (n = 161), 9.32 and 19.25% reported one or more diagnosed concussion and suspected concussion respectively as a result of a skiing- or snowboarding-related incident. Skiers and snowboarders that self-identified as advanced, those who utilized terrain park features, and those that participated in freestyle competition had significantly higher self-reported rates of concussion. Conclusion: Self-reported concussion history indicates a concussion prevalence that is higher than expected based on previous studies. Participants reported significantly more suspected concussions than diagnosed concussions, indicating a possible issue with underreporting in this population.
Synthesis, Characterization, and Anti-inflammatory activity of Some Novel Oxazole Derivatives
Authors: Garg Ajay Kumar , Singh Ranjan Kumar , Saxena Vaibhav , Sinha Saurabh Kr. , Rao Sanjay 
Published: January 2023

A series of novel oxazole derivatives (A, A1, A2) were synthesized starting from acetone and urea. The compound (A) was obtained by heating it with acetophenone and urea in iodine. Compound (A) on treatment with 4-amino benzaldehyde (Z)-N-(4-amino benzylidine)-4-((E)-Penta-2, 4-diene-2) oxazole-2-amine afforded (A1). Acylation of compound (A) with 4-amino benzoyl chloride to obtain the corresponding N-(4 phenyl oxazole-2- yl)- benzamide (A2). The structures of compounds have been established employing FTIR and 1H-NMR spectral analysis. All oxazole derivatives were evaluated for anti-inflammatory activity by the carrageenan-induced Rat hind paw method. Derivative A1 shows maximum anti-inflammatory activity.
Keywords: Oxazoles, anti-inflammatory, Benzamide, acetophenone, indomethacin.
A Review on Strategies for COVID-19 Vaccine Development and Regulatory Requirements
Authors: Kulkarni Rohan , Kallepalli Sai Priya , Dharia Samit , Kamble Girish , Parvathaneni Madhukiran 
Published: January 2023

Scientists first identified Human Coronavirus in the year 1965. Then, a study was performed on different human and animal viruses, which were named based on their crown-like appearance. Human coronaviruses are responsible for many children's upper respiratory tract infections. At least five new human coronaviruses have been identified since 2003, including the severe acute respiratory syndrome (SARS) coronavirus, which caused significant morbidity and mortality.1 Per NL and the New Haven, the virus associated with upper and lower respiratory tract disease and likely common human pathogens are identified as the Group-I coronaviruses (SARS- CoV-I). The novel coronavirus (SARS-CoV-II), which appeared in Wuhan, China, in December 2019, is responsible for Coronavirus disease 2019 (COVID-19) and causes respiratory symptoms that can feel like a cold, flu, or pneumonia. Geographical transmission of the virus and the sudden increase in cases are much faster than SARS and Middle East respiratory syndrome (MERS). COVID-19 is the first global pandemic caused by a coronavirus causing outbreaks in 211 countries. The vaccine against COVID-19 is an effective prophylactic strategy for controlling and preventing the virus. The vaccine is being developed in about 90 institutions worldwide. This research paper focuses on COVID-19 vaccine development strategies implemented by various institutions and pharmaceutical companies worldwide and regulatory requirements for vaccine approval.
Keywords: Human Coronavirus, Severe Acute Respiratory Syndrome (SARS), COVID-19 vaccine development strategies
Pharmacological evaluation of analgesic, anti-pyretic and anti-inflammatory activities of ethanolic root extract of Amaranthus caudatus
Authors: Kumar Vivek , Monika Km , Rathi Bhawana , Agarwal Ruchi , Khan Najam Ali , Swain Sudhansu Ranjan 
Published: January 2023

Background: Amaranthus caudatus Linn, belonging to a family Amaranthaceae. Amaranthus caudatus is found in South America, India, or Indo-Chinese district, Mexico, and the Mediterranean area. Amaranthus caudatus contains different kinds of substance constituents which are responsible for its therapeutic potential. Amaranthus caudatus is usually utilized in the treatment of jaundice, amoebiasis, and kidney ailment, as a blood purifier, diuretic, abortifacient, vermifuge, astringents, and for liver illness. The research work deals with the screening of the analgesic, antipyretic and anti-inflammatory activities of ethanolic root extract of Amaranthus caudatus. For this, the alcoholic extract of the selected plant was used for analgesic activity, anti-inflammatory activity and anti-pyretic activities.
The result: In current investigation, diclofenac sodium (10mg/kg, p.o.) was used as a standard drug. The effects of ethanolic root extract (200 and 400mg/kg, p.o.) of Amaranthus caudatus on Wistar albino rats for the assessment of analgesic, anti-inflammatory as well as antipyretic activities. The current research revealed that EEAC (200 and 400mg/kg,p.o.) possessed significant (P<0.05) analgesic, anti-inflammatory and antipyretics activities in a dose-dependent manner. Furthermore EEAC (200 and 400mg/kg p.o) were effective as standard drug (Diclofenac sodium 10mg/kg, p.o). All these methods were performed under highly supervised conditions and by proper handling of experimental animals having been granted permission by IAEC.
The conclusion: In the present study, it was concluded that the EEAC was effective in a dose-dependent manner and possessed potent analgesic, anti-inflammatory and antipyretic activities.
Keywords: Amaranthus caudatus, Analgesic, Anti-pyretic, Anti-inflammatory, Diclofenac sodium, Phytochemical screening.
An investigation of Baccharoides anthelmintica (L.) Moench seed extract for antibacterial and antioxidant activities
Authors: Prakash Ved 
Published: January 2023

Use of herbal remedies is on the rise in developed and developing countries. Plant kingdom is a gold mine for novel and affordable antimicrobial and antioxidant compounds. The medicinal properties of plants are due to metabolites especially secondary compounds produced by plant species around the globe. The current study was designed to investigate the seed extract of Baccharoides anthelmintica (L.) Moench for its antibacterial and antioxidant activities. The antibacterial activity of the acetone, aqueous and methanol seed extracts was determined in-vitro against medically important pathogens such as Bacillus cereus, Escherichia coli, Listeria monocytogenes, Pseudomonas aeruginosa, Staphylococcus aureus and Yersinia pestis by agar-well diffusion method using different concentrations (25, 50, 75 and 100%). Results showed low to significant antibacterial activity against the mentioned pathogenic bacterial species. The methanol extract of B. anthelmintica showed maximum zone of inhibition (20.40±0.68 mm) in the growth of L. monocytogenes which was followed by P. aeruginosa (19.10±1.77 mm), S. aureus (18.55±2.20 mm), E. coli (16.00±0.60 mm) and Y. pestis (16.00±0.00 mm) at 100% of its concentration respectively. Methanol seed extract was found to be more effective against selected pathogenic bacterial species as compared to acetone and aqueous seed extracts. Further the seed extract inhibited gram-positive bacteria more efficiently than gram-negative bacteria. The antioxidant capacity of the different seed extracts (methanol, acetone and aqueous) of B. anthelmintica was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay at different concentrations (20, 40, 60, 80 and 100 µg/mL). The plant showed 14.40±0.05 and 13.20±0.55 % DPPH radical scavenging potential in methanol and acetone extracts respectively at 100 µg/mL and exhibited no radical scavenging potential in case of aqueous extract. Therefore, the seed extracts of this plant can be selected for further investigation to discover or determine their ultimate therapeutic potential.
Keywords: Baccharoides anthelmintica, seed extract, agar well diffusion, zone of inhibition, DPPH
Radioligand therapy with drugs based on radionuclide <sup>225</sup>Aс: experience of A.M.Granov Russian scientific center of radiology and surgical technologies
Authors: Maystrenko D. N. , Stanzhevskii A. A. , Vazhenina D. A. , Odintsova M. V. , Popov S. A. , Nomokonova V. B. , Chipiga L. A. , Saprykin K. A. , Gromov A. V. , Vasiliev S. K. 
Published: January 2023

INTRODUCTION: Peptide receptor therapy based on the 225Ac radionuclide, due to the targeted effect on tumor cells, is the most promising method of treatment for patients with generalized forms of neuroendocrine tumors and castration-resistant prostate cancer.OBJECTIVE: The aim of the work was to evaluate the effectiveness of radioligand therapy of medicinal radiopharmaceuticals with 225Ac.MATERIALS AND METHODS: Radioligand therapy based on 225Ac radionuclide was performed in 7 patients with generalized prostate cancer and 3 patients with neuroendocrine tumors.RESULTS: Systemic radiation therapy with 225Ac-PSMA 617 and 225Ac-DOTATE showed its effectiveness in clinical practice — patients have a decrease in the level of accumulation of the radiopharmaceutical (RP) in pathological foci on PET-CT with 68Ga-PSMA and 68Ga-DOTATE; a decrease in the level of prostate-specific antigen (PSA) in the blood (for prostate cancer); reduction of manifestations of asthenic, pain and carcinoid (for neuroendocrine tumors) syndromes. Dosimetric studies make it possible to assess the biodistribution of a radiopharmaceutical drug in the body, accumulation in target organs and lesions.CONCLUSION: The appointment of this type of treatment requires an integrated approach based on a thorough study of medical records, assessment of the receptor status of the tumor tissue, timely detection and prediction of adverse reactions.
La précarité alimentaire au regard du développement physique des enfants de rue dans l’air du Champ-de-Mars
Authors: Desrosin Veronia Louis 
Published: January 2023

Cet article vise à réfléchir sur les conséquences négatives de la précarité alimentaire des enfants de rue dans l’air du Champ-de-Mars, Port-au-Prince, Haïti. De nombreuses recherches sur la nutrition nous permettent d’apprendre sur les bienfaits d’une bonne alimentation et sur la croissance physique de l’enfant. En général, pour avoir une bonne nutrition, il faut respecter les 3 catégories d’aliments essentiels : les aliments énergétiques, les aliments, constructeurs et réparateurs, les aliments protecteurs et régulateurs. Pour réaliser cette recherche nous avons effectué une visite auprès de 10 enfants de rue dans l’air de Champ-de-Mars, à travers un questionnaire, dans l’objectif de savoir 1) combien de fois mangent-ils les enfants dans une journée ? Qu’est-ce qu’ils mangent naturellement ? Et, comment font-ils pour gagner de la nourriture ? En matière de résultat global, nous avons pu constater que ces enfants de rue ne bénéficient pas d’une alimentation équilibrée, alors que leur situation nutritionnelle ne fait qu’aggraver, ils ne mangent qu’occasionnellement durant une journée. À Haïti, même les chanceux des classes sociales privilégiées n’ont pas accès aux soins de santé digne qu’adviennent ces enfants s’ils tombent malades à cause de carences alimentaires ? Les enfants de rue de l’air de Champ-de-Mars ont besoin et urgemment une action immédiate pour mettre en place des mesures pour lutter contre ce problème.
DANA DARURAT DI MASA PANDEMI COVID-19
Authors: Kumajas Lydia Ivana , Wuryaningrat Nikolas Fajar 
Published: January 2023

ABSTRACTIn financial management, the main issue in financial planning is estimating future cash flows, because it is influenced by various risks. One way to reduce risk is by placing an emergency fund. During the Covid-19 pandemic, the importance of financial planning was seen by placing an emergency fund when individuals, families, and companies experienced economic problems due to the Covid-19 pandemic. This study aims to describe the communities’ awareness and knowledge and their readiness to face ‘rainy day’ by preparing financial umbrella or emergency fund, and whether the greater the income, the greater the umbrella allocated as stated in Keynes's theory. Descriptive research methods are used to get this picture. Online survey with Survey Monkey application was conducted on a small portion of the community in various regions in Indonesia. The results of this study showed that 91 community members were aware of emergency fund, although not all of them prepared it. The interesting finding is that high-income respondents were not of the group which allocated bigger emergency fund. Hence, this could not give fit descriptions with Keynes Theory. Keywords: Pandemic of Covid-19; rainy day; Keynes theory; emergency fund ABSTRAKDalam manajemen keuangan, kesulitan utama dalam membuat perencanaan adalah mengestimasi arus kas di masa depan, karena dipengaruhi oleh berbagai risiko. Salah satu cara untuk mengurangi risiko adalah membuat perencanaan keuangan dengan menempatkan dana darurat. Di masa pandemi Covid-19 ini terlihat pentingnya perencanaan keuangan dengan menempatkan dana darurat atau ketika individu/perusahaan mengalami masalah ekonomi akibat pandemi Covid-19. Penelitian ini bertujuan mendapatkan gambaran kesadaran dan pengetahuan masyarakat dan kesiapannya menghadapi keadaan sulit ‘rainy day’ dengan menyiapkan dana darurat sebagai payung keuangan, dan apakah semakin besar penghasilan maka akan semakin besar dana darurat yang dialokasikan seperti yang dikemukakan dalam teori Keynes. Metode penelitian deskriptif digunakan untuk mendapatkan gambaran tersebut. Survei online dengan aplikasi Survey Monkey dilakukan pada sebagian kecil masyarakat di berbagai daerah di Indonesia. Hasil penelitian dari 91 responden sebagian besar sudah mengetahui mengenai dana darurat, akan tetapi walaupun mengetahui pentingnya dana darurat tidak semua sudah menyediakan dana tersebut. Menariknya, responden pada kelompok penghasilan tertinggi bukanlah kelompok yang mengalokasikan dana darurat paling besar. Dengan demikian, tidak terlalu memberikan gambaran yang sesuai dengan teori Keynes.Kata kunci: Pandemi Covid-19; risiko; teori Keynes; dana darurat
Prediction of mental strength from the satisfaction of basic needs in CABA and GBA esports players
Authors: González Caino Pablo Christian 
Published: January 2023

Background: Esports are here to stay. Previous studies have shown that sports athletes have characteristics Esports are here to stay. Previous studies have shown that esports athletes have similar characteristics, such as satisfaction from competing, as those in traditional sports. However, being an area still growing, few studies have addressed them in Latin America. This study aimed to determine the relationship and predictors of mental toughness from the satisfaction of basic needs in amateur esports players from the Autonomous City of Buenos Aires and Greater Buenos Aires, Argentina. Methods: For this, a sample of 426 participants (85% male) was constituted, with a mean age of 22 years (SD = 3.67), who answered the Basic Needs Satisfaction in Sport Scale (BNSSS) and the Mental Toughness Index (MTI) questionnaire, as well as a sociodemographic questionnaire. Results: The results indicated a strong relationship between both variables, especially with the dimensions of competence satisfaction and perception of choice, also being the main predictors of mental strength. Conclusions: These results provide new empirical evidence for this area in formation, as well as different issues to be taken into account to develop mental strength and sporting success in esports.