bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pleading Nolo Contendere? Aquinas vs. Bonaventure on Poetry
Authors: Belleza Jose Isidro 
Published: March 2023

AbstractWhile the story of Thomas Aquinas and Bonaventure of Bagnoregio engaging in a friendly contest, at the behest of Pope Urban IV, to compose the Mass and Office of Corpus Christi is likely a pious fiction, one can still ponder the fascinating hypothetical scenario: had such a contest taken place, who might have won? To consider that question, this paper embarks on a close reading of Bonaventure's hymns in his Office of the Passion, comparing his poetic approaches to those of Aquinas in the hymns for Corpus Christi. After an introductory historical examination into the supposed involvement of both friars in the composition of the Corpus Christi liturgy, this article proceeds in three sections. First, a look into select excerpts from Bonaventure's Office of the Passion will establish his general poetic technique. In the transitional second section, a direct comparison between Bonaventure and Aquinas on the composition of the final doxological verses of their respective hymns will place their different poetic styles into greater relief. Third, a broader reading of Aquinas's Eucharistic hymns will highlight the unique qualities of his versified praises. Finally, in light of the foregoing analyses, a prospective winner of the hypothetical contest will be suggested.
Global patterns and climatic determinants of phylogenetic structure of regional fern floras
Authors: Qian Hong , Kessler Michael , Zhang Jian , Jin Yi , Jiang Meichen 
Published: March 2023

Summary

Knowledge of relationships between phylogenetic structure of a biological assemblage and ecological factors that drive the variation of phylogenetic structure among regions is crucial for understanding the causes of variation in taxonomic composition and richness among regions, but this knowledge is lacking for the global flora of ferns. Here, we fill this critical knowledge gap.

We divided the globe into 392 geographic units on land, collated species lists of ferns for each geographic unit, and used different phylogenetic metrics (tip‐ vs basal‐weighted) reflecting different evolutionary depths to quantify phylogenetic structure. We then related taxonomic and phylogenetic structure metrics to six climatic variables for ferns as a whole and for two groups of ferns (old clades vs polypods) reflecting different evolutionary histories across the globe and within each continental region.

We found that when old clades and polypods were considered separately, temperature‐related variables explained more variation in these metrics than did precipitation‐related variables in both groups. When analyses were conducted for continental regions separately, this pattern holds in most cases.

Climate extremes have a stronger relationship with phylogenetic structure of ferns than does climate seasonality. Climatic variables explained more variation in phylogenetic structure at deeper evolutionary depths.
The role of religious contexts on hate crimes, 2003–2017
Authors: Ratcliff Shawn , Schwadel Philip 
Published: March 2023

AbstractObjectiveCombining insights from socio‐criminological theories of (hate) crimes and the moral communities perspective, this article examines how the religious makeup of a county—evangelical Protestant, mainline Protestant, and Catholic adherence rates—affects county‐level hate crime patterns.MethodsZero‐inflated negative binomial regressions were conducted on a unique county‐level data set that included reported hate crimes, religious adherence rates, and related correlates of hate crimes for three distinct temporal periods: 2003–2007, 2008–2012, and 2013–2017.ResultsResults demonstrate that a county's total adherence rate, mainline Protestant rate and, to a lesser degree, Catholic adherence rate are associated with fewer hate crimes. We find no evidence that the evangelical Protestant adherence rate is associated with the number of hate crimes.ConclusionThese results support the moral communities hypothesis, extend research on the religion–crime nexus, and highlight the distinction between religious and secular organizations in community‐level crime patterns, particularly hate crimes.
UGT76F1 glycosylates an isomer of the C7‐necic acid component of pyrrolizidine alkaloids in Arabidopsis thaliana
Authors: Chen Han‐Yi , Li Xin , Chapple Clint , Dilkes Brian , Li Xu 
Published: March 2023

SUMMARYIdentification of unknown metabolites and their biosynthetic genes is an active research area in plant specialized metabolism. By following a gene–metabolite association from a genome‐wide association study of Arabidopsis stem metabolites, we report a previously unknown metabolite, 2‐hydroxy‐2‐(1‐hydroxyethyl)pentanoic acid glucoside, and demonstrated that UGT76F1 is responsible for its production in Arabidopsis. The chemical structure of the glucoside was determined by a series of analyses, including tandem MS, acid and base hydrolysis, and NMR spectrometry. T‐DNA knockout mutants of UGT76F1 are devoid of the glucoside but accumulate increased levels of the aglycone. 2‐hydroxy‐2‐(1‐hydroxyethyl)pentanoic acid is structurally related to the C7‐necic acid component of lycopsamine‐type pyrrolizidine alkaloids such as trachelantic acid and viridifloric acid. Feeding norvaline greatly enhances the accumulation of 2‐hydroxy‐2‐(1‐hydroxyethyl)pentanoic acid glucoside in wild‐type but not the UGT76F1 knockout mutant plants, providing evidence for an orthologous C7‐necic acid biosynthetic pathway in Arabidopsis despite the apparent lack of pyrrolizidine alkaloids.
A leaf‐emanated signal orchestrates grain size and number in response to maternal resources
Authors: Ta Kim Nhung , Shimizu‐Sato Sae , Agata Ayumi , Yoshida Yuri , Taoka Ken‐ichiro , Tsuji Hiroyuki , Akagi Takashi , Tanizawa Yasuhiro , Sano Ryosuke , Nosaka‐Takahashi Misuzu , Suzuki Toshiya , Demura Taku , Toyoda Atsushi , Nakamura Yasukazu , Sato Yutaka 
Published: March 2023

SUMMARYIn plants, variations in seed size and number are outcomes of different reproductive strategies. Both traits are often environmentally influenced, suggesting that a mechanism exists to coordinate these phenotypes in response to available maternal resources. Yet, how maternal resources are sensed and influence seed size and number is largely unknown. Here, we report a mechanism that senses maternal resources and coordinates grain size and number in the wild rice Oryza rufipogon, a wild progenitor of Asian cultivated rice. We showed that FT‐like 9 (FTL9) regulates both grain size and number and that maternal photosynthetic assimilates induce FTL9 expression in leaves to act as a long‐range signal that increases grain number and reduces size. Our findings highlight a strategy that benefits wild plants to survive in a fluctuating environment. In this strategy, when maternal resources are sufficient, wild plants increase their offspring number while preventing an increase in offspring size by the action of FTL9, which helps expand their habitats. In addition, we found that a loss‐of‐function allele (ftl9) is prevalent among wild and cultivated populations, offering a new scenario in the history of rice domestication.
On a theorem by Browder and its application to nonlinear boundary value problems
Authors: Amster Pablo 
Published: March 2023

AbstractIn a paper from 1960, Felix Browder established a theorem concerning the continuation of the fixed points of a family of continuous functions depending continuously on a parameter , where is a convex and compact subset of . Here, the result is presented for a compact mapping where is a convex, closed, and bounded subset of an arbitrary normed space and is an arcwise connected topological space. Applications to nonlinear boundary value problems are given; specifically, we shall present new viewpoints of known results, introduce some novel results, and exhibit some open problems.
Menstrual health and hygiene among young Palestinian female university students in the West Bank: a cross-sectional study
Authors: Hassan Sahar , Ghandour Rula , Bakri Lamia , Shwiki Siham , Safi Sara , Abuzaid Reem , Zeidan Hiba 
Published: March 2023

ObjectiveWe investigated some aspects of menstrual health and hygiene among young female students at Birzeit University in the West Bank of the occupied Palestinian territory.DesignCross-sectional study in a large central university.ParticipantsOut of a total of 8473 eligible female students, a calculated sample size of 400 students aged between 16 and 27 years was obtained.SettingLarge central university, West Bank, occupied Palestinian territory (oPt).MeasuresAn anonymous structured international research instrument consisting of 39 questions based on the Menstrual Health Questionnaire, in addition to few questions relevant to the context, was administered.Results30.5% of participants were not informed about menstruation before menarche, and 65.3% reported that they were not ready when they got their first period. The highest reported source of information regarding menstruation was family (74.1%), followed by school (69.3%). About 66% of respondents reported that they need more information on various topics of menstruation. The most common type of menstrual hygiene products used were single-use pads (86%), followed by toilet paper (13%), nappies (10%) and reusable cloths (6%). Of the total 400 students, 14.5% reported that menstrual hygiene products are expensive, and 15.3% reported that they always/sometimes had to use menstrual products that they do not like because they are cheaper. Most (71.9%) of the respondents reported that they used menstrual products for longer time than recommended due to inadequate washing facilities at the university campus.ConclusionsThe findings provide useful evidence on the lack and the need for menstrual-related information for female university students, inadequate infrastructure to help them manage their menstruation with dignity and pointed to some menstrual poverty in accessing menstrual products. A national intervention programme is needed to increase awareness regarding menstrual health and hygiene among women in local communities and female teachers in schools and universities to enable them to disseminate information to and meet the practical needs of girls at home, at school and at the university.
Geodesic motion on the symplectic leaf of $$SO(3)$$ with distorted e(3) algebra and Liouville integrability of a free rigid body
Authors: Deriglazov Alexei A. 
Published: March 2023

AbstractThe solutions to the Euler–Poisson equations are geodesic lines of SO(3) manifold with the metric determined by inertia tensor. However, the Poisson structure on the corresponding symplectic leaf does not depend on the inertia tensor. We calculate its explicit form and confirm that it differs from the algebra e(3). The obtained Poisson brackets are used to demonstrate the Liouville integrability of a free rigid body. The general solution to the Euler–Poisson equations is written in terms of exponential of the Hamiltonian vector field.
OTUB1 Catalytic-Independently Deubiquitinates TGFBI and Mediates the Angiogenesis in Infantile Hemangioma by Regulating Glycolysis
Authors: Li Mingyang , Wang Xuan , Yang Enli , Li Yiming , Geng Yiming , Chen Zhanwei , Huang Shengyun , Zhang Dongsheng , Wu Haiwei 
Published: March 2023

Background:
Infantile hemangioma (IH) arises as a result of dysregulation of both angiogenesis and vasculogenesis. The deubiquitylase OTUB1 (OTU domain, ubiquitin aldehyde binding 1) has been reported to play an essential role in multiple cancers; however, its function in the progression of IH and the underlying mechanisms regulating angiogenesis remain unclear.

Methods:
Transwell assays, EdU assays, and tube formation assays were performed to investigate the biological behavior of IH in vitro. IH animal models were established to estimate the progression of IH in vivo. Mass spectrometric analysis were conducted to detect the downstream of OTUB1 and ubiquitination sites of transforming growth factor beta induced (TGFBI). Half-life assays and ubiquitination test were performed to investigate the interaction between TGFBI and OTUB1. Extracellular acidification rate assays were employed to estimate the glycolysis level in IH.

Results:
The expression of OTUB1 was obviously increased in proliferating IH as compared to the involuting and involuted IH tissues. Through in vitro experiments, the knockdown of OTUB1 inhibited the proliferation, migration and tube formation of human hemangioma endothelial cells, while the overexpression of OTUB1 promoted the proliferation, migration and angiogenic abilities of human hemangioma endothelial cells. The knockdown of OTUB1 significantly suppressed IH progression in vivo. Furthermore, TGFBI was predicted as a functional downstream target of OTUB1 in IH by mass spectrometry. Mechanistically, OTUB1 interacted with and deubiquitylated TGFBI on the K22 and K25 residues, which was demonstrated to be independent of the catalytic activity of OTUB1. The inhibitory effects of OTUB1 knockdown on cell proliferation, migration and tube formation ability of human hemangioma endothelial cells were reversed by TGFBI overexpression. Further, we found that OTUB1 mediated glycolysis by regulating TGFBI in infantile hemangioma.

Conclusions:
OTUB1 deubiquitinates TGFBI in a catalytic-independent manner and promotes angiogenesis in infantile hemangioma by regulating glycolysis. Targeting OTUB1 might be an effective therapeutic strategy for inhibiting IH progression and tumor angiogenesis.
The Unconscious in Rosenzweig’s The Star of Redemption: On the Threshold of a Possible Revelation
Authors: Pinkas Ronen 
Published: March 2023

Abstract
This paper discusses Franz Rosenzweig’s use of the term “the unconscious” (das Unbewußte) and possible influences on his understanding of it. I claim that for Rosenzweig, it is through the unconscious that the individual becomes aware of himself and becomes capable of fulfilling his longing to achieve self-fulfillment and eventually to take part in a collective redemption. The unconscious is often perceived as the mental sphere related to trauma and repression in which defense mechanisms and fantasies are evolved. Fantasies are psychological tools that allow the individual to cope with trauma, but they are also “layers of enclosedness,” illusions that should be dissolved. Hence, in the unconscious, we find a possibility of liberation.
Nasopharyngeal Fibroangioma: Revisiting the “Other End” of the Spectrum
Authors: Panja Tanaya , Dutta Mainak , Kadambott Sharafali 
Published: March 2023

Significance Statement Nasopharyngeal angiofibroma rarely presents in post-adolescent and elderly men, either as the natural evolution of a pre-existing lesion or as a de novo skull-base tumor. As the lesion ages, its composition changes from vessel-predominant to stroma-predominant—the angiofibroma–fibroangioma spectrum. As a fibroangioma, it has restrained clinical features (asymptomatic or occasional epistaxis), minimal avidity for contrast agents, and limited spread potential evident on imaging. These atypical features lead to a diagnostic dilemma when an innocuous choanal/nasopharyngeal fibrovascular mass is encountered in hitherto asymptomatic adult men presenting with epistaxis.
Trifecta and Carpentier Edwards aortic bioprostheses: Comparison of six years follow-up outcomes
Authors: Pfister Raymond , Frey Vincent , Kirsch Matthias , Tozzi Piergiogio , Delay Dominique , Gunga Ziyad , Prêtre René , Niclauss Lars 
Published: March 2023

Background To compare mid-term clinical outcomes and hemodynamic performance of the stented pericardial Trifecta bioprosthesis for surgical aortic valve replacement (AVR) with a technically comparable commonly used surgical bioprosthesis. Methods Data from consecutive patients implanted with the TF or the Carpentier Edwards Magna Ease valve were retrospectively analyzed. Primary analysis was performed on a propensity score–matched cohort. Primary endpoints included the composite of death or reoperation and structural valve deterioration. The comparison also included echocardiographic assessments at one-week post-AVR and at the last documented follow-up. Results Two propensity score–matched groups of 170 patients each were identified from the overall population ( n = 486). Incidence of postoperative mortality (2.9% vs. 7.1%, respectively, p = 0.08), and patient prosthesis mismatch (1.2% and 2.4%, p = 0.41) were similar. At mean follow-up of 5.84 (Trifecta) and 6.1 (Carpentier Edwards) years, the incidence of all-cause death/reoperation (15.3% vs. 15.9%, p = 0.88 for Trifecta and Carpentier Edwards, respectively) and structural valve disease (1.8% vs. 2.9%, p = 0.47) were similar. Overall, postoperative mean transvalvular pressure gradients were significantly lower in the Trifecta group than in the Carpentier Edwards group (7.7 ± 3.3 vs. 11.3 ± 3.6 mmHg, p < 0.01). Mean transvalvular gradient remained significantly lower through the last follow-up for small-sized Trifecta valves (19/21 mm; 10.5 ± 4.2 vs. 13.8 ± 5.9 mmHg, p = 0.039) but not for larger valves (10.3 ± 4.8 vs. 9.4 ± 3.5 mmHg, p = 0.31). Conclusion The Trifecta valve is a valuable alternative to the Carpentier Edwards valve in terms of safety, hemodynamic performance, and mid-term durability. Smaller-sized valves provide additional clinical benefits, given their persistent hemodynamic advantages through mid-term follow-up.
The Impact of Patient Characteristics and Antiplatelet Regimes on Clot Microstructure in Patients Treated for ST Elevation Myocardial Infarction: Clot Microstructure can Evaluate Therapeutic Efficacy
Authors: Lawrence Matthew J. , Obaid Daniel R. , Sabra Ahmed , Whitley Janet , Quarry Rhianwen , Pillai Suresh , Chase Alexander J. , Smith David , Williams Phylip R. , Hawkins Karl , Morris Roger H.K. , Evans Phillip A. 
Published: March 2023

Background Unfavourable clot microstructure is associated with adverse outcomes in ST elevation myocardial infarction (STEMI). We investigated the effect of comorbidities and anti-platelet treatment on clot microstructure in STEMI patients using fractal dimension (df), a novel biomarker of clot microstructure derived from the visco-elastic properties of whole blood. Methods Patients with STEMI (n = 187) were recruited sequentially receiving aspirin with Clopidogrel (n = 157) then Ticagrelor (n = 30). Patient characteristics and blood for rheological analysis obtained. We quantified df using sequential frequency sweep tests to obtain the phase angle of the Gel Point which is synonymous with the clot microstructure. Results Higher df was observed in males (1.755 ± 0.068) versus females (1.719 ± 0.061, p = .001), in patients with diabetes (1.786 ± 0.067 vs 1.743 ± 0.046, p < .001), hypertension (1.760 ± 0.065 vs 1.738 ± 0.069, p = .03) and previous MI (1.787 ± 0.073 vs 1.744 ± 0.066, p = .011) compared to without. Patients receiving Ticagrelor had lower df than those receiving Clopidogrel (1.708 ± 0.060 vs 1.755 ± 0.067, p < .001). Significant correlation with df was found with haematocrit (r = 0.331, p < .0001), low-density lipoprotein (LDL) (r = 0.155, p = .046) and fibrinogen (r = 0.182, p = .014). Following multiple regression analysis, diabetes, LDL, fibrinogen and haematocrit remained associated with higher df while treatment with Ticagrelor remained associated with lower df. Conclusions The biomarker df uniquely evaluates the effect of interactions between treatment and underlying disease on clot microstructure. STEMI patients with diabetes and elevated LDL had higher df, indicating denser clot. Ticagrelor resulted in a lower df than Clopidogrel signifying a less compact clot.
Quality and readability of online information on hand osteoarthritis
Authors: Hong Seok Woo , Kang Jeong-Hyun , Park Jun Hyoung , Park Hee Jin , Kim Eugene 
Published: March 2023

Objectives: This study aimed to evaluate the quality and readability of web pages providing information about hand osteoarthritis using several authorized methods. Methods: A web page exploration was performed using the Google internet search engine. The three search terms, “hand osteoarthritis,” “finger osteoarthritis,” and “hand OA,” were used and the top 100 ranked websites were selected and divided into six categories. The Health on the Net Foundation (HON) grade scale, an instrument for judging the quality of written consumer health information on treatment choice (DISCERN instrument), and the Ensuring Quality Information for Patients (EQIP) score were used to evaluate the quality of each website. The Flesch-Kincaid reading ease (FRE) score, Flesch-Kincaid grade (FKG) level, Gunning-Fog index, and Simple Measure of Gobbledygook grade level were used to evaluate website readability. Results: Among 300 websites, 57 websites were selected following exclusion criteria. News portal websites, including the online version of newspapers and periodicals, showed the highest score in all three quality evaluation tools. Only four websites were regarded as high-quality websites based on the HON grade scale ( n = 3) and the EQIP score ( n = 1). Each type of website showed an average FKG level higher than 7th grade and obtained an average FRE score of less than 80 points, indicating an inappropriate level for a layperson to read. Conclusions: The online information about hand osteoarthritis is low quality and difficult to read for the general public. There is a need to enhance the quality and readability of web-based information related to hand osteoarthritis for patients to obtain credible information and receive proper treatment for the disease.
Persistent Sciatic Artery in Right Lower Extremity Complicated by Thrombosis: A Case Report
Authors: Liu Boyang , Hu Bingbing , Li Fang , Min Zhenqi , Yuan Supeng , Dai Xianpeng 
Published: March 2023

Purpose: Persistent sciatic artery (PSA) is a rare congenital vascular malformation with an incidence of approximately 0.025% to 0.04%. Persistent sciatic artery has major complications, such as aneurysms, thrombosis, and occlusion. Complications may lead to a range of serious clinical problems, and a timely diagnosis of this vascular variant is crucial to avoid life-threatening complications. Case: A 65-year-old man was admitted to the hospital with pain and chills in the right lower extremity for 2 months, which gradually worsened. This was accompanied by numbness in the right foot for the last 10 days. Computed tomography angiography showed that the right inferior gluteal artery and right popliteal artery of the right internal iliac artery were connected, which is considered a congenital developmental variant. This was complicated by multiple thromboses of the right internal and external iliac arteries, and the right femoral artery. After admission to the hospital, the patient underwent endovascular staging surgery to relieve numbness and pain in the lower extremities. Conclusion: Treatment strategies can be selected based on the anatomical characteristics of PSA and superficial femoral artery. Asymptomatic patients with PSA can be closely monitored. Surgery or individualized endovascular treatment plans should be considered for patients with aneurysm formation or vascular occlusion. Clinical Impact For the rare vascular variation of the PSA, clinicians must make a timely and accurate diagnosis. Ultrasound screening is essential, which requires experienced ultrasound doctors to be aware of vascular interpretation and develop personalized treatment plans for each patient. In this case, we adopt staged a minimally invasive intervention to solve the problem of lower limb ischemic pain for patients. This operation has the advantages of rapid recovery and less trauma, which has important reference significance for other clinicians.