bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust backstepping global integral terminal sliding mode controller to enhance dynamic stability of hybrid AC/DC microgrids
Authors: Roy Tushar Kanti , Ghosh Subarto Kumar , Saha Sajeeb 
Published: March 2023

AbstractIn this paper, a Backstepping Global Integral Terminal Sliding Mode Controller (BGITSMC) with the view to enhancing the dynamic stability of a hybrid AC/DC microgrid has been presented. The proposed approach controls the switching signals of the inverter, interlinking the DC-bus with the AC-bus in an AC/DC microgrid for a seamless interface and regulation of the output power of renewable energy sources (Solar Photovoltaic unit, PMSG-based wind farm), and Battery Energy Storage System. The proposed control approach guarantees the dynamic stability of a hybrid AC/DC microgrid by regulating the associated states of the microgrid system to their intended values. The dynamic stability of the microgrid system with the proposed control law has been proved using the Control Lyapunov Function. A simulation analysis was performed on a test hybrid AC/DC microgrid system to demonstrate the performance of the proposed control strategy in terms of maintaining power balance while the system’s operating point changed. Furthermore, the superiority of the proposed approach has been demonstrated by comparing its performance with the existing Sliding Mode Control (SMC) approach for a hybrid AC/DC microgrid.
Gadolinium retention in a rat model of subtotal renal failure: are there differences among macrocyclic GBCAs?
Authors: Bonafè Roberta , Coppo Alessandra , Queliti Roberta , Bussi Simona , Maisano Federico , Kirchin Miles A. , Tedoldi Fabio 
Published: March 2023

Abstract
Background
Gd levels are higher in tissues of animals with compromised renal function, but studies to compare levels after exposure to different macrocyclic gadolinium-based contrast agents (GBCAs) are lacking. We compared Gd levels in tissues of subtotally nephrectomised (SN) rats after repeated exposure to macrocyclic GBCAs.

Methods
Sprague–Dawley SN male rats (19 per group) received 16 injections of gadoteridol, gadobutrol, or gadoterate meglumine at 0.6 mmol Gd/kg 4 times/weeks over 4 weeks. A control group of healthy male rats (n = 10) received gadoteridol at the same dosage. Plasma urea and creatinine levels were monitored. Blood, cerebrum, cerebellum, liver, femur, kidney(s), skin and peripheral nerves were harvested for Gd determination by inductively coupled plasma-mass spectrometry at 28 and 56 days after the end of treatment.

Results
Plasma urea and creatinine levels were roughly twofold higher in SN rats than in healthy rats at all timepoints. At day 28, Gd levels in the peripheral nerves of gadobutrol- or gadoterate-treated SN animals were 5.4 or 7.2 times higher than in gadoteridol-treated animals (p < 0.001). Higher Gd levels after administration of gadobutrol or gadoterate versus gadoteridol were also determined in kidneys (p ≤ 0.002), cerebrum (p ≤ 0.001), cerebellum (p ≤ 0.003), skin (p ≥ 0.244), liver (p ≥ 0.053), and femur (p ≥ 0.271). At day 56, lower Gd levels were determined both in SN and healthy rats for all GBCAs and tissues, except the femur.

Conclusions
Gd tissue levels were lower following gadoteridol exposure than following gadobutrol or gadoterate exposure.
Detection method of absence seizures based on Resnet and bidirectional GRU
Authors: Li Lijun , Zhang Hengxing , Liu Xiaomei , Li Jie , Li Lei , Liu Dan , Min Jieqing , Zhu Ping , Xia Huan , Wang Shangkun , Wang Li 
Published: March 2023

Abstract
Background
Epilepsy is a common chronic neurological disease. Its repeated seizure attacks have a great negative impact on patients’ physical and mental health. The diagnosis of epilepsy mainly depends on electroencephalogram (EEG) signals detection and analysis. There are two main EEG signals detection methods for epilepsy. One is the detection based on abnormal waveform, the other is the analysis of EEG signals based on the traditional machine learning. The feature extraction method of the traditional machine learning is difficult to capture the high-dimension information between adjacent sequences.

Methods
In this paper, redundant information was removed from the data by Gaussian filtering, downsampling, and short-time Fourier transform. Convolutional Neural Networks (CNN) was used to extract the high-dimensional features of the preprocessed data, and then Gate Recurrent Unit (GRU) was used to combine the sequence information before and after, to fully integrate the adjacent information EEG signals and improve the accuracy of the model detection.

Results
Four models were designed and compared. The experimental results showed that the prediction model based on deep residual network and bidirectional GRU had the best effect, and the test accuracy of the absence epilepsy test set reached 92%.

Conclusions
The prediction time of the network is only 10 sec when predicting four-hour EEG signals. It can be effectively used in EEG software to provide reference for doctors in EEG analysis and save doctors’ time, which has great practical value.
Phosphorus in waste sources in Southern Vietnam: potential for recovery
Authors: Dinh Khang Vu , Le Hung Anh , Pfennig Andreas 
Published: March 2023

AbstractThe potential for phosphorus (P) recovery from various sources in Southern Vietnam has been assessed in this study. Five types of waste were studied, namely sediment from catfish pond, manure from cattle and pig farming, and also sludge from domestic and rubber-latex processing wastewater-treatment plants. The study identifies P-reserve and assesses factors related to P recovery from waste sources such as distribution, collection, transportation conditions, and composition of wastes. P-reserve from catfish farming is estimated about 17.7 kt yr-1 while reserve from pig farming is the highest, about 21.7 kt yr-1. Total P-reserves from studied wastes are estimated about 50 kt yr-1, equivalent to 37% of Vietnam’s imported nutrient P quantity in 2019. Generated sludge from rubber-latex processing wastewater-treatment plants has the highest potential and favorable properties for P recovery. It turns out to be feasible to collect and recover P from this waste source under Vietnam’s current conditions.
Clinical characteristics of bipolar 1 disorder in relation to interleukin-6: a cross-sectional study among Egyptian patients
Authors: Hassan May , Elzehery Rasha , Mosaad Youssef M. , Mostafa Maged , Elkalla Ibrahem H. Rashed , Elwasify Mohamed 
Published: March 2023

Abstract

Background
Strong evidence in the literature points to the role of pro-inflammatory cytokines in bipolar disorder (BD) pathophysiology. Interleukin-6 (IL-6) is a pro and anti-inflammatory cytokine that was repeatedly found higher in bipolar patients than in healthy controls. However, studies on the phasic differences of IL-6 in bipolar type I (BP-I) were limited. This study aims to explore the phasic differences of serum IL-6 levels in BP-I during euthymia, depression, and mania and their association with the disease’s clinical characteristics in a sample of Egyptian BP-I patients. Thirty currently euthymic, 24 currently depressed, 29 currently manic BP-I patients, and 20 healthy subjects were recruited. Serum IL-6 levels were compared among BP-I groups and then between each group and a group of 20 healthy controls. Serum IL-6 levels (pg/ml) were measured with a sandwich enzyme-linked immunosorbent assay (ELISA). Depression and mania symptoms were assessed using the Hamilton Depression Rating Scale (HDRS) and the Young Mania Rating Scale (YMRS), respectively. Clinical characteristics were evaluated through a semi-structured clinical psychiatric interview, and cognitive status was tested using the Montreal Cognitive Assessment (MoCA).

Results
Serum IL-6 levels were significantly higher in each bipolar phase than in healthy subjects. In the BP-I patients, IL-6 levels were lower in patients with a current manic episode than in patients with a current depressive episode (P < 0.05) or who were currently euthymic (P < 0.001). Moreover, IL-6 levels correlated inversely with the YMRS score (rs =  − 0.29; P < 0.05). Compared to patients without psychotic features, patients with psychotic features had decreased serum IL-6. Moreover, IL-6 levels were lower in inpatients compared to outpatients.

Conclusions
BP-I disorder is associated with an inflammatory state. The decreased levels of IL-6 during manic episodes, affective episodes with psychotic features, and their inverse correlation with the severity of mania symptoms indicate a possible anti-inflammatory role of IL-6 in mania and psychotic symptoms pathogenesis.
Impact of biological and non-biological treatment on hematological indices in patients with ankylosing spondylitis and psoriatic arthritis
Authors: Aboud Fatma Mohammed , Galal Salwa , Elwafa Menna Allah Zakaria Abou , Farouk ALshymaa Mohammed 
Published: March 2023

Abstract
Background
Blood dyscrasias are common in patients with rheumatic diseases, as bone marrow and blood cells can be targets for autoimmune processes. This in addition to the potentially adverse effect of the disease-modifying anti-rheumatic drugs used for the treatment of inflammatory arthritis as in psoriatic arthritis (PsA) and ankylosing spondylitis (AS) on blood counts.

Aim of this study
The aim of this study is to analyze the effect of biologic therapy on complete blood cell parameters, derived ratios, and cell volume indices in Egyptian patients with ankylosing spondylitis and psoriatic arthritis.

Results
One hundred and twenty Egyptian patients had been included, 60 have ankylosing spondylitis (AS) and 60 have psoriatic arthritis (PSA). On comparing the blood indices between the biologics and non-biologics groups of PSA patients, there was a statistically highly significant reduction in red cell distribution width (RDW%) at the biologics group than non-biologics (p < 0.006), where there was a statistically highly significant increase in Hb (hemoglobin)/RDW ratio and Hb/platelets ratio at the biologics group than non-biologics (p < 0.005).

Conclusion
As a result, biologic drugs used in rheumatology practice may have some effects on hematological parameters. In our study, no major negative effects on hematological parameters were observed in patients with AS and PsA who received Secukinumab, Adalimumab-atto, or Golimumab biologic therapy. However, the changes in the hematological indices correlates with their potent anti-inflammatory action in rheumatic patients.
Attempting to document and rehabilitate Aleppo between 1994 and 2011: the ramifications of pre-conflict built heritage mismanagement and the effects of the scarcity of documentation on options available for post-conflict conservation
Authors: Zeido Zeido 
Published: March 2023

AbstractThis paper examines several aspects of the attempt at rehabilitating Aleppo and the data available about the city prior to the start of the Syrian conflict in 2011. It discusses documentation, rehabilitation and conservation practices in Aleppo, focusing on the operations between 1994 and 2011 that were coordinated by several institutions managed primarily by the Directorate of the Old City of Aleppo (DOCA) and the Gesellschaft für Technische Zusammen­arbeit (GTZ). The analysis considers not only the old city, which is inscribed on the World Heritage List, but also other historic and culturally significant areas in Aleppo. This research primarily uses notes from other scholarly resources, statements by various relevant experts, and the reports and documents produced by the DOCA, the GTZ, and UNESCO to argue that some of the practices during that period were in part responsible for overlooking important aspects and places of the city’s built heritage. The paper then explains the ramification of these approaches, which are still perceptible today, on the prospects for any future efforts to safeguard the city’s built heritage.
Scenario-based earthquake damage assessment of highway bridge networks
Authors: Abo-El-Ezz Ahmad , Farzam Azarm , Fezai Hamza , Nollet Marie-José 
Published: March 2023

AbstractIn earthquake-prone regions, the evaluation of seismic impacts on bridges is crucial to mitigation, emergency, and recovery planning for highway networks. The degree of bridge damage determines the cost and time required for repairs and the level of post-earthquake functionality including disruption of transportation network, increased costs due to reduction of traffic flow and restricted access to emergency routes. The article presents the methodological development and implementation of an interactive web application for rapid geospatial assessment and visualisation of earthquake damage scenarios of municipal highway bridge networks based on open access datasets. The proposed framework consists of the following successive models: hazard, inventory, damage, and impact. The seismic hazard model generates spatial distribution of the shaking intensity for earthquake scenarios in terms of ground motion intensity measure using ground motion prediction equations based on seismic hazard model for Eastern Canada. The shaking intensities are then modified with local site amplification factors based on the Canadian highway bridge design code values. The inventory model provides a database of existing bridges based on open-access data which are then classified according to their seismic vulnerability. The damage model assesses seismic performance of classes of bridges by applying respective fragility functions represented as probabilistic relationships between the intensity measure and the degree of expected damage. The impact model evaluates the post-earthquake traffic-carrying capacity of the highway network based on the predicted damage including repair cost as a percentage of replacement cost of bridges and inspection priority. The web-application is demonstrated with a bridge network in Quebec City including 117 bridges subjected to 180 earthquake scenarios. The proposed methodology is particularly useful to facilitate direct communication of potential impacts to emergency managers and city transport officials.
Tenets for Implementing Electronic Patient-Reported Outcomes for Remote Symptom Monitoring During Cancer Treatment
Authors: Basch Ethan , Rocque Gabrielle , Mody Gita , Mullangi Samyukta , Patt Debra 
Published: March 2023

PURPOSE Symptoms are common in patients receiving systemic treatment for metastatic cancer. Monitoring patients with electronic patient-reported outcomes (ePROs) detects severe and worsening symptoms early, enabling care teams to intervene and prevent downstream complications and thereby improving outcomes. The Centers for Medicare & Medicaid Services will require patient-reported outcome (PRO) monitoring in the upcoming Enhancing Oncology Model, and many practices will likely attempt to implement PROs in patient care for the first time. METHODS To assist practices with the design and implementation of ePRO remote symptom monitoring programs, tenets were drawn from prior ePRO program experiences and research. RESULTS Successful implementation requires a quality improvement approach to change management with attention to software functionality, measured outcomes, personnel deployment, leadership and culture, workflow, equity, and patient engagement. Specific approaches in each of these areas can optimize program participation and effectiveness. Continuous program monitoring to identify and address barriers is essential to success. Initial challenges with personnel acceptance and patient participation are common and can be overcome by using these tenets. CONCLUSION Remote symptom monitoring with ePROs is a key component of quality cancer care and population health management that requires organizational commitment and a deliberate approach by practices using established tenets to assure successful implementation.
Iteration-free digital quantum simulation of imaginary-time evolution based on the approximate unitary expansion
Authors: Wen Jingwei , Zheng Chao , Huang Zhiguo , Qian Ling 
Published: March 2023

Abstract
Imaginary-time evolution plays an important role in many areas of quantum physics and has been widely applied to the ground-state determination of various Hamiltonian in the quantum computation field. In this work, we propose an iteration-free quantum algorithm in a full gate-based frame using the approximate unitary expansion to simulate the imaginary-time evolution operator, avoiding the resource overhead caused by repeated measurement for state reconstruction or complex pre-calculations in the classical computers. We detail the algorithm and analyze the complexity and related characteristics including a lower bound for ancillary qubits at a given success probability. Then an application demonstration of the algorithm in quantum chemistry with hydrogen molecule under noiseless and noisy conditions is offered. In addition, we present another imaginary-time evolution simulation method based on similar construction schemes. Our algorithms can serve as the alternative proposals for the imaginary-time evolution realization in the future fault-tolerant quantum computers.
Aggressive Pituitary Tumors and Pituitary Carcinomas: From Pathology to Treatment
Authors: Burman Pia , Casar-Borota Olivera , Perez-Rivas Luis Gustavo , Dekkers Olaf M 
Published: March 2023

AbstractAggressive pituitary tumors (APTs) and pituitary carcinomas (PCs) are heterogeneous with regard to clinical presentation, proliferative markers, clinical course, and response to therapy. Half of them show an aggressive course only many years after the first apparently benign presentation. APTs and PCs share several properties, but a Ki67 index greater than or equal to 10% and extensive p53 expression are more prevalent in PCs. Mutations in TP53 and ATRX are the most common genetic alterations; their detection might be of value for early identification of aggressiveness.Treatment requires a multimodal approach including surgery, radiotherapy, and drugs. Temozolomide is the recommended first-line chemotherapy, with response rates of about 40%. Immune checkpoint inhibitors have emerged as second-line treatment in PCs, with currently no evidence for a superior effect of dual therapy compared to monotherapy with PD-1 blockers. Bevacizumab has resulted in partial response (PR) in few patients; tyrosine kinase inhibitors and everolimus have generally not been useful. The effect of peptide receptor radionuclide therapy is limited as well.Management of APT/PC is challenging and should be discussed within an expert team with consideration of clinical and pathological findings, age, and general condition of the patient. Considering that APT/PCs are rare, new therapies should preferably be evaluated in shared standardized protocols. Prognostic and predictive markers to guide treatment decisions are needed and are the scope of ongoing research.
SGLT2 Inhibitors: Effect on Myocardial Infarction and Stroke in Type 2 Diabetes
Authors: Mukhopadhyay Pradip , Sanyal Debmalya , Chatterjee Purushottam , Pandit Kaushik , Ghosh Sujoy 
Published: March 2023

Abstract

Background
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have recently been recommended as preferred agents for management of hyperglycemia in type 2 diabetes, primarily based on their ability to reduce a composite of major cardiovascular adverse events (3-point major adverse cardiovascular events [MACE]), predominantly by reducing cardiovascular death. However, reduction of the individual components, myocardial infarction (MI), or stroke (fatal and nonfatal) events have not been well explored.

Methods
In this meta-analysis, we included data available from cardiovascular outcome trials only, which were event-driven, randomized, and placebo-controlled. Pooled efficacy outcomes included Mantel Haenszel (MH) risk ratio using fixed model (with 95% CI) for fatal and nonfatal MI, stroke, and total MI and stroke.

Findings
Data from 4 eligible trials included 42,568 subjects. Total MACE, MI, and stroke were reported in 4176, 2157, and 1288 subjects, respectively. SGLT2is did not significantly reduce either MI or stroke individually or in totality. The MH risk ratio (95% CI) for fatal and nonfatal MI and stroke with different SGLT2is was found to be 0.93 (95% CI, 0.85-1.01) and 1.00 (95% CI, 0.89-1.11), respectively. For total atherosclerotic cardiovascular disease (ASCVD) events, MH risk ratio (95% CI) was 0.95 (95% CI, 0.89-1.02). For all nonfatal ASCVD (combined nonfatal MI and nonfatal stroke), MH risk ratio (95% CI) was 0.94 (95% CI, 0.88-1.02).

Interpretation
SGLT2is reduce MACE without any discernable significant reduction of the incidence of MI or stroke (fatal and nonfatal), probably implicating mechanisms unrelated to anti-atherogenic effects.
Critical Border Zones and Anti-extractive Thinking
Authors: Coletta Michela 
Published: March 2023

AbstractWhile the notion of the Anthropocene signals the urgency for a climate transition, it stops short of restructuring the anthropocentric principles of the dominant economic and societal model. Pluriversal decolonial designs being debated and practiced in Latin America treat the crisis of the current civilizational model as an opportunity to propose alternatives that seek to reconceptualize the ways in which we organize social life. This article brings to light nondualistic epistemologies and argues that the anti-extractivist designs needed for building regenerative futures go hand in hand with anti-colonial epistemic resistance. A central part of the analysis focuses on the Aymara-Bolivian thinker Silvia Rivera Cusicanqui, whose relational ontology allows us not only to confront the colonial legacy of the Anthropocene but also to acknowledge the global diffusion of coloniality. Through the Aymara linguistic concept of ch’ixi—a parallel coexistence of difference—Rivera Cusicanqui proposes new ways of building community beyond colonial dualisms and around socioecological knowledges.
If It’s Vacant Take It
Authors: Goldstein Zoe 
Published: March 2023

AbstractThis article reframes the current housing crisis in Oakland, California as environmental injustice and as an ongoing effect of racial capitalism. It also highlights recent examples of citizen-led land reclamation, which it argues retaliate against city-sponsored erasure of precariously housed residents and offer the potential to address economic, racial, and environmental injustice simultaneously. By disrupting the status quo of real estate price gouging and visibly reestablishing community on Oakland’s streets, these movements demonstrate alternatives to the capitalist dehumanization and manufactured scarcity at the heart of Oakland’s housing crisis.