bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Relationship of Serum Cd163, Ykl40 and Vilip-1 Levels with Autism Severity and Language-Cognitive Development in Preschool Children with Autism
Authors: DEMİRCİ Samet Can , BARUN Süreyya , ÖZASLAN Ahmet , GÜLBAHAR Özlem , BULUT Tuba Saadet DEVECİ , ÇAMURDAN Aysu DUYAN , İŞERİ Elvan 
Published: September 2023

Abstract

This study aimed to compare serum levels of CD163, YKL-40, and VILIP-1 between children with autism spectrum disorder (ASD) and healthy controls, while also investigating their association with the severity of ASD and language development. The study included 40 ASD-diagnosed patients (aged 1–6 years) and 40 age-matched healthy controls. Childhood Autism Rating Scale (CARS), Preschool Language Scale-4 (PLS-4), and Ankara Development Screening İnventory (ADSI) were administered to children in the ASD group. Serum CD163, YKL-40 and VILIP-1 levels were measured with an enzyme-linked immunosorbent assay kit. In the ASD group compared to the control group, serum VILIP-1 levels were significantly higher (p = 0.046). No significant differences were observed in mean serum CD163 and YKL-40 levels between patients and controls (p = 0.613, p = 0.769). Interestingly, a positive correlation was observed between CD163 and YKL-40 levels and ASD severity (p < 0.001 for both). Additionally, CD163 and YKL-40 levels showed significant predictive value for ASD severity. While no significant associations were found between CD163 and YKL-40 levels and language development, a negative correlation was observed between VILIP-1 levels and language development (p < 0.001). Our findings highlight that the levels of CD163 and YKL-40 significantly predicted ASD severity, indicating a potential role of neuroinflammation in the development of ASD.
Utilization of Cross-Correlation Function for Assessment of Replication Quality in Ultrasonic Embossing of Microchannels on Polymethyl Methacrylate (PMMA)
Authors: Yildirim Ender , Ulku Mert Kerem , Arikan M.A. Sahir 
Published: September 2023

Abstract

Ultrasonic embossing is a promising method for fabricating microchannels on thermoplastics due to reduced cycle time and relatively low equipment cost. Replication quality in ultrasonic embossing has been investigated in the literature by primarily referring to the replication depth. However, this approach does not fully reflect the fidelity between the mold and the replicated feature, especially at the side walls, which are typically designed as vertical in microchannels. We propose to utilize cross-correlation between the gradients of the mold profile and the embossed profile as a figure of merit sensitive to the side wall’s fidelity. For testing purposes, we embossed straight microchannels on polymethyl methacrylate (PMMA) using a brass mold comprising 100, 300, and 1000 µm-wide protrusions of same designed height of 300 µm, resulting in aspect ratios (AR) of 3, 1, and 1/3, respectively. Cross-correlations between the gradients of the pofiles ranged between 0.50 and 1.00, while cross-correlations between the profiles were greater than 0.97 in all cases, showing the sensitivity imposed by utilizing the gradients. Setting average of all cross-correlation values (0.8) as the quality threshold, we observed that high AR (3) features were replicated at low quality, while low AR (1/3) features were replicated at high quality, regardless of the process parameters. In replicating unit AR features, the process parameters were observed to affect the quality, where the combination of vibration time and pressure was the most significant compared to individual effects of the parameters.
Comparing Video Laryngoscopy and Direct Laryngoscopy for Tracheal Intubation in Critically Ill Adults: A Comprehensive Updated Meta-Analysis and Systematic Review
Authors: Azam •	Saad , Kha •	Zainab Zaib , Siddiqui •	Aisha , Masood •	Natasha , •	Anum  , Ahmed •	Usman , Arif •	Yumna , Memon •	Zeenat Umair , Khawar •	Muhammad Hasnain , Siddiqui •	Farina Fatima 
Published: September 2023

Abstract
Background: Direct laryngoscopy was the modality used in successful trachea intubation. With the advancements in science, video laryngoscopy was introduced to conduct the same procedures with enhancements in viewing glottic views. In emergency settings, both laryngoscopes are commonly used for intubations. This study compares which is more successful in first-attempt tracheal intubation in critically ill patients.
Materials and methods: The PubMed database was thoroughly searched for this systematic review and meta-analysis. All RCTs and Observational studies until 2023 were included, whose primary outcome was the first attempt at successful tracheal intubation. The secondary outcomes were severe hypoxemia, severe hypotension, and cardiac arrest.
Results: In emergency situations, the success rate of intubation on the first attempt was significantly higher in video laryngoscopy than in direct laryngoscopy. The risk ratio was 1.19 (95% CI 1.10 to 1.29) with a heterogeneity of I2 = 75%. However, there was no significant correlation found between video laryngoscopy and severe hypoxemia, severe hypotension, or cardiac events. The risk ratio for severe hypoxemia was 0.99 (95% CI 0.74 to 1.33), for severe hypotension was 0.19 (95% CI 0.83 to 1.72), and for cardiac events, the risk ratio was 1.17 (95% CI 0.37 to 3.70). The P value was non-significant for these secondary outcomes, indicating that these complications were not associated with video laryngoscopy. The heterogeneity among the secondary outcomes was much lower than that of the primary outcome. It's important to note that there was substantial heterogeneity among the outcomes.
Conclusion; our updated meta-analysis has confirmed that video laryngoscopy (VL) has a higher success rate for first-pass intubation than direct laryngoscopy (DL). As a result, we recommend using VL over DL for critically ill patients. Furthermore, our analysis has shown no significant evidence linking VL to any adverse events.
Trends in Consumer Preferences for Product Customization and their Application in Product Design
Authors: Powell Carter , Yang Sheng 
Published: September 2023

Abstract

Consumer preferences play an important role in the decision to customize a product. The collection of consumer preferences can be a challenging task and most methods require significant effort while only focusing on one specific product or product type. A popular method of collecting consumer preferences is a survey as it is easy to administer and can be tailored to gather specific desirable information. In this paper, a survey is developed to gather consumer preferences for product customization with a focus on identifying trends amongst these preferences. User preferences are correlated to factors of success in customization and categorical definitions of product attributes. Twenty-five products were evaluated, with one hundred total responses collected. The results show the existence of product clusters that represent trends amongst consumer preferences for customization. The trends and clusters identified have potential applications in the design of novel customized products by using categorical representations to generalize the findings. This method of generalization can provide cost and time savings in the product design cycle for future customized products by reducing the effort required to elicit consumer preferences.
Water and Nitrate‐Nitrogen Losses From a Small, Upland, Coastal Plain Watershed
Authors: Hubbard R. K. , Sheridan J. M. 
Published: September 2023

AbstractSurface runoff (SRO) and shallow‐subsurface flow (SSF) from a small, upland, Coastal Plain watershed underlain by plinthite were monitored for a 10‐y period. Samples collected during surface runoff and subsurface‐flow events were analyzed for NO3‐N. The major water runoff loss from the system was found to be subsurface flow, accounting for 79% of total runoff loss, which occurred primarily from December through May. Nitrate‐N concentrations in surface runoff and subsurface flow were relatively uniform over the period, averaging 0.47 and 8.75 mg/L, respectively. The combination of high volume of subsurface flow and its relatively high NO3‐N content, resulted in 99% of total NO3‐N loss via subsurface flow. Predictive equations for monthly surface and subsurface water runoff losses from this watershed were developed using multiple linear regression. The equations contain seasonal and climatic parameters, including pan evaporation. Tests of the equations with observed results gave significant (P ≤ 0.01) correlation coefficients, r, of 0.82 and 0.85 for surface runoff and subsurface flow, respectively. Mean surface and subsurface NO3‐N concentrations were multiplied by predicted monthly flows to compute predicted monthly NO3‐N losses. Comparison of predicted and actual monthly NO3‐N losses gave significant (P ≤ 0.01) correlation coefficients, r, of 0.59 and 0.86 for surface and subsurface flows, respectively. The good fit of predicted and observed results can be partially attributed to the seasonal and climatic data base collected over a relatively long period of 10 y.
Risk Perception, Risk Communication, and Stakeholder Involvement for Biosolids Management and Research
Authors: Beecher Ned , Harrison Ellen , Goldstein Nora , McDaniel Mary , Field Patrick , Susskind Lawrence 
Published: September 2023

ABSTRACTAn individual's perception of risk develops from his or her values, beliefs, and experiences. Social scientists have identified factors that affect perceptions of risk, such as whether the risk is knowable (uncertainty), voluntary (can the individual control exposure?), and equitable (how fairly is the risk distributed?). There are measurable differences in how technical experts and citizen stakeholders define and assess risk. Citizen knowledge and technical expertise are both relevant to assessing risk; thus, the 2002 National Research Council panel on biosolids recommended stakeholder involvement in biosolids risk assessments. A survey in 2002 identified some of the factors that influence an individual's perception of the risks involved in a neighbor's use of biosolids. Risk communication was developed to address the gap between experts and the public in knowledge of technical topics. Biosolids management and research may benefit from applications of current risk communication theory that emphasizes (i) two‐way communications (dialogue); (ii) that the public has useful knowledge and concerns that need to be acknowledged; and (iii) that what may matter most is the credibility of the purveyor of information and the levels of trustworthiness, fairness, and respect that he or she (or the organization) demonstrates, which can require cultural change. Initial experiences in applying the dialogue and cultural change stages of risk communication theory—as well as consensus‐building and joint fact‐finding—to biosolids research suggest that future research outcomes can be made more useful to decision‐makers and more credible to the broader public. Sharing control of the research process with diverse stakeholders can make research more focused, relevant, and widely understood.
Evaluating Livestock System Environmental Performance with Whole‐Farm Nutrient Balance
Authors: Koelsch Rick 
Published: September 2023

ABSTRACTAs a part of the USEPA's concentrated animal feeding operation (CAFO) final rule, all CAFOs are required to develop and implement a nutrient management plan (NMP). The USEPA's emphasis on better management of nutrients appropriately targets a critical environmental issue associated with animal production. The concentration of animals in livestock feeding operations, often separate from feed grain production, requires importing of substantial quantities of feed nutrients. Due to the inefficiencies of nutrient utilization in livestock production, quantities of nitrogen (N) and phosphorus (P) in manure greater than can be utilized in local crop production often result. With the focus of the USEPA's NMP rules on internal farm manure management planning, nutrient concentrations resulting from animal concentration may not be adequately addressed by compliance with the USEPA rules alone. A review of two mandatory and two voluntary nutrient management strategies is made by comparing whole‐farm nutrient balance for a case‐study beef cattle feedlot. The results suggest that voluntary BMPs, such as modification to animal feeding program and exporting of manure, can have greater environmental benefits (30–60% reduction in P accumulation for case‐study farm) than mandatory NMPs and buffers (5–7% reduction in P accumulation for case‐study farm) for a typical beef cattle feedlot. Whole‐farm nutrient balance procedures can also be valuable for reviewing the nutrient performance of livestock systems.
Bacterial Diversity in Selenium Reduction of Agricultural Drainage Water Amended with Rice Straw
Authors: Siddique Tariq , Okeke Benedict C. , Zhang Yiqiang , Arshad Muhammad , Han Suk K. , Frankenberger William T. 
Published: September 2023

ABSTRACTBacterial reduction of the Se oxyanions selenate [Se(VI)] and selenite [Se(IV)] to elemental selenium [Se(0)] is an important biological process in removing Se from drainage water. This study was conducted to characterize the molecular diversity of bacterial populations involved in Se reduction of drainage water amended with rice (Oryza sativa L.) straw and also to monitor the bacterial community shifts during the course of the study. Selenate was removed in the drainage water by the bacteria 5 to 6 d after addition of rice straw. Six Se(VI)‐ and 32 Se(IV)‐reducing bacteria were isolated from rice straw containing sterilized drainage water. Three Se(VI)‐ and two Se(IV)‐reducing bacteria were also isolated from the drainage water. Identification of Se(VI)‐ and Se(IV)‐reducing bacteria by 16S rDNA sequence analysis showed a broad phylogenetic diversity in Se‐reducing assemblages. Three major phyla (Proteobacteria, Actinobacteria, and Firmicutes) of bacterial domain with numerous classes, orders, and families constituted the Se‐reducing bacterial community. We documented changes in the composition of bacterial assemblages in the drainage water amended with rice straw using polymerase chain reaction (PCR)–denaturing gradient gel electrophoresis (DGGE) of 16S rDNA. The Shannon–Weaver index (H′) revealed higher bacterial diversity at Day 6 in the sterilized and Day 4 in the nonsterilized drainage water amended with rice straw. The results of this study suggest that rice straw, a good source of carbon and energy, harbors a wide range of bacteria useful in Se reduction and may be used in removing Se from drainage water.
Tillage Erosion and Its Effect on Soil Properties and Crop Yield in Denmark
Authors: Heckrath G. , Djurhuus J. , Quine T. A. , Van Oost K. , Govers G. , Zhang Y. 
Published: September 2023

ABSTRACTTillage erosion had been identified as a major process of soil redistribution on sloping arable land. The objectives of our study were to investigate the extent of tillage erosion and its effect on soil quality and productivity under Danish conditions. Soil samples were collected to a 0.45‐m depth on a regular grid from a 1.9‐ha site and analyzed for137Cs inventories, as a measure of soil redistribution, soil texture, soil organic carbon (SOC) contents, and phosphorus (P) contents. Grain yield was determined at the same sampling points. Substantial soil redistribution had occurred during the past decades, mainly due to tillage. Average tillage erosion rates of 2.7 kg m−2yr−1occurred on the shoulderslopes, while deposition amounted to 1.2 kg m−2yr−1on foot‐ and toeslopes. The pattern of soil redistribution could not be explained by water erosion. Soil organic carbon and P contents in soil profiles increased from the shoulder‐ toward the toeslopes. Tillage translocation rates were strongly correlated with SOC contents, A‐horizon depth, and P contents. Thus, tillage erosion had led to truncated soils on shoulderslopes and deep, colluvial soils on the foot‐ and toeslopes, substantially affecting within‐field variability of soil properties. We concluded that tillage erosion has important implications for SOC dynamics on hummocky land and increases the risk for nutrient losses by overland flow and leaching. Despite the occurrence of deep soils across the study area, evidence suggested that crop productivity was affected by tillage‐induced soil redistribution. However, tillage erosion effects on crop yield were confounded by topography–yield relationships.
Atrazine Sorption–Desorption Hysteresis by Sugarcane Mulch Residue
Authors: Selim H. M. , Zhu H. 
Published: September 2023

ABSTRACTSorption and desorption kinetics are essential components for modeling the movement and retention of applied agricultural chemicals in soils and the fraction of chemicals susceptible to runoff. In this study, we investigated the retention characteristics of sugarcane (Saccharum spp. hybrid) mulch residue for atrazine (2‐chloro‐4‐ethylamino‐6‐isopropylamino‐1,3,5‐triazine) based on studies of sorption–desorption kinetics. A sorption kinetic batch method was used to quantify retention of the mulch residue for a wide range of atrazine concentrations and reaction times. Desorption was performed following 504 h of sorption using successive dilutions, followed by methanol extraction. Atrazine retention by the mulch residue was well described using a linear model where the partitioning coefficient (Kd) increased with reaction time from 10.40 to 23.4 cm3 g−1 after 2 and 504 h, respectively. Values for mulch residue Kd were an order of magnitude higher than those found for Commerce silt loam (fine‐silty, mixed, superactive, nonacid, thermic Fluvaquentic Endoaquepts) where the sugarcane crop was grown. A kinetic multireaction model was successful in describing sorption behavior with reaction time. The model was equally successful in describing observed hysteretic atrazine behavior during desorption for all input concentrations. The model was concentration independent where one set of model parameters, which was derived from all batch results, was valid for the entire atrazine concentration range. Average atrazine recovery following six successive desorption steps were 63.67 ± 4.38% of the amount adsorbed. Moreover, a hysteresis coefficient based on the difference in the area between sorption and desorption isotherms was capable of quantifying hysteresis of desorption isotherms.
Phosphorus Leaching in Manure‐Amended Atlantic Coastal Plain Soils
Authors: Butler Jennifer S. , Coale Frank J. 
Published: September 2023

ABSTRACTTargeting the sources of phosphorus (P) and transport pathways of drainage from agricultural land will assist in the reduction of P loading to surface waters. Our research investigated the vertical movement of P from dairy manure and broiler litter through four Atlantic Coastal Plain soils. A randomized split‐plot design with two main‐plot tillage treatments (no tillage [NT] and chisel tillage [CH]) and five manure P rate split‐plot treatments was used at each location. The split‐plot P rates were 0, 100, 200, 300, and 400 kg P ha−1 yr−1 Four consecutive years of manure application began at all sites 5 yr before sampling. Soils were sampled to a depth of 150 cm from each split plot in seven depth increments and analyzed for soil test phosphorus (STP), water‐extractable soil phosphorus (WSP), and degree of phosphorus saturation (DPS). The DPS of the 0‐ to 15‐cm depths confirmed that at the 100 kg P ha−1 yr−1 application rate, all sites exceeded the threshold for P saturation (30%). At depths greater than 30 cm, DPS was typically below the 30% saturation threshold. The DPS change points ranged from 25 to 34% for the 0‐ to 90‐cm depths. Our research concluded that the risk of P leaching through the matrix of the Atlantic Coastal Plain soils studied was not high; however, P leaching via macropore bypass may contribute to P loss from these soils.
FORSTER’S ITALIAN NOVELS AS A TESTGROUND FOR A PASSAGE TO INDIA
Authors: Crnogorac Branko Č. 
Published: September 2023

M. Forster is one of the authors whose auto-referentiality manifests itself on several levels, from the choice of themes regarding his novels and short stories, over his styllistic features, leitmotifs, symbols, and clear social engagement with concern to major global issues, to the transtextuality of his characters as, probably, the most outstanding one.
Through the prism of some key notions of colonial/postcolonial discourse, the paper deals with Forster's 'Italian novels' (A Room with a View and Where Angels Fear to Tread) as a testground for some of the themes and motifs elaborated in A Passage to India.
Liuwei Dihuang Prevents Human Umbilical Vein Endothelial Cells Senescence via the JPX-STING-IRF3 Pathway
Authors: Xu Chao , Cai Tiantian , Du Xinghai 
Published: September 2023

Background:
Cellular senescence plays a crucial role in age-related diseases. Endothelial senescence is closely associated with age-related vascular disorders. This study aimed to reveal the role of traditional Chinese medicine Liuwei Dihuang (LWDH) in anti-endothelial cell senescence.

Methods:
Human umbilical vein endothelial cells (HUVECs) were exposed to LPS treatment to induce senescence. Senescence-associated β-galactosidase (SA-β-gal) positive staining, p53 and p16 expression, BrdU staining, and relative telomere length (RTL) experiments were conducted to estimate LPS-induced cellular senescence of HUVECs. Real-time qPCR analysis was performed to identify differentially expressed lncRNAs in LPS-induced senescent HUVECs before and after treatment with LWDH. Bioinformatics analysis and ChIP assay were conducted to explore the mechanism of JPX in the anti-endothelial cell aging effect of LWDH.

Results:
We first discovered that lncRNA JPX and STING-IRF3 pathways are involved in the process of anti-endothelial senescence of LWDH. Mechanistically, LWDH could reverse abnormally elevated JPX induced by LPS and inhibit the activation of STING, as well as the interaction between JPX and STING.

Conclusion:
Overall, our study explores the potential therapeutic value of LWDH and provides key insights into the potential avenues for preventing and treating HUVECs senescence.
Naphthoquinone Derivatives Targeting Melanoma
Authors: Nunes Jéssica Alves , da Silva Nunes Adrielle Firmino , da Paz Lima Dimas José , da Silva-Júnior Edeildo Ferreira 
Published: September 2023

Abstract:
Cancer is responsible for high mortality rates worldwide, representing a serious health
problem. In this sense, melanoma corresponds to the most aggressive type of skin cancer, being the
cause of the highest death rates. Therapeutic strategies for the treatment of melanoma remain limited,
with problems associated with toxicity, serious side effects, and mechanisms of resistance. The
potential of natural products for the prevention and treatment of melanoma has been reported in different
studies. Among these compounds, naphthoquinones (1,2-naphthoquinones and 1,4-naphthoquinones)
stand out for their diverse pharmacological properties, including their antitumor activity.
Thus, this review covers different studies found in the literature on the application of natural naphthoquinones
targeting melanoma, providing information regarding the mechanisms of action investigated
for these compounds. Finally, we believe that this review provides a comprehensive basis
for the use of natural naphthoquinones against melanoma and that it may contribute to the discovery
of promising compounds, specifically naphthoquinones, aimed at the treatment of this cancer.