bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-Release Testing coverage-based SRGM considering error generation and change-point incorporating the random effect
Authors: Bibyan Ritu , Anand Sameer , Aggarwal Anu G. , Tandon Abhishek 
Published: May 2023

Abstract
The most essential step during the development of the software is the testing procedure which makes the software dependable and efficient. During this procedure, the observation and rectification of the faults play a significant role in increasing the reliability of the software. Various Software Reliability growth models (SRGMs) with multiple assumptions were presented by various researchers to study the software’s reliability. It is well known that the fault observation rate may get affected by irregular factors causing arbitrary effects. In this study, we aim to capture this irregular variation in fault observation rate by expressing it in terms of testing coverage. The fault observation/removal process has been assumed as a stochastic process and modeled it using an Itô type of stochastic differential equation. Testing coverage enables software designers to check the software’s excellence and to see if any extra efforts are required to enhance reliability. In this paper, we have developed an SRGM based on testing coverage by introducing the concept of changepoint, error generation, and irregular fluctuations. The error generation implies that during the testing procedure faults are not disclosed entirely and more faults get introduced. Later on, we focused on the idea of multi-release by considering four releases. We have estimated the parameters of the model by using fault dataset for consecutive releases of Tandem Computers and validated the performance by evaluating the goodness-of-fit criteria.
Prediction of asthma using a four-locus gene model including IL13, IL4, FCER1B, and ADRB2 in children of Kazak nationality
Authors: Bai Shasha , Lu Jun , Hua Li , Liu Quanhua , Chen Mengxue , Gu Yutong , Zhang Jianhua , Ma dongjun , bao yixiao 
Published: May 2023

Abstract
Background: To study whether the four locus gene model consisting of ADRB2rs1042713, IL4 rs2243250, FCER1B rs569108 and L13 rs20541 can predict asthma of the Kazak children in Xinjiang, China.
Methods: Four single nucleotide polymorphisms about the 4 genes were genotyped in asthma group and control group of Han children and Kazak children respectively. The frequencies of different genotypes and alleles were compared between the asthma group and the control group in the two nationalities. Different risk genotypes for asthma were evaluated in the two nationalities.
Results: The differences about frequencies of genotypes in ADRB2 rs1042713 and IL4 rs2243250 and IL13 rs20541 between asthma group and control group were statistically significant in Han children, as were the frequencies of alleles in the 3 single nucleotide polymorphisms, but there were no statistical differences in FCER1Brs569108(P>0.05). For the Kazak children, no differences were existed among all the genotypes and alleles in asthma group and control group. For the Han children, more children were asthma high risk genotype in the asthma group than those in the control group and no difference was found in the Kazak children.
Conclusions: The four locus gene model consisting of ADRB2rs1042713, IL4 rs2243250, FCER1B rs569108 and L13 rs20541 can predict asthma of Han children but not for the Kazak children in Xinjiang, which illustrating that the difference of asthma prevalence between different races is closely related to the genetic background.
Network meta-analysis on efficacy and safety of different biologics for ulcerative colitis
Authors: Chu Xinqiao , Biao Yaning , Guo Yufeng , Liu Chengjiang , Gu Yaru , Zhang Yixin , Liu Chenxu 
Published: May 2023

Abstract
Background:Therapeutic options for ulcerative colitis (UC) have increased since the introduction of biologics a few decades ago. Due to the wide range of biologics available, physicians have difficulty in selecting biologics and do not know how to balance the best drug between clinical efficacy and safety. This study aimed to compare the efficacy and safety of biologics in treating ulcerative colitis.
Methods: In this study, eight electronic databases (PubMed, Web of Science, Cochrane, Embase, Sinomed, China National Knowledge Infrastructure, Chongqing VIP Information, and WanFang Data) were searched to collect eligible studies without language restrictions. Retrieved 6 September 2022, from inception. All articles included in the mesh analysis are randomised controlled trials (RCTs). The inclusion of drugs for each outcome was ranked using a curved surface under cumulative ranking (SUCRA). Higher SUCRA scores were associated with better outcomes, whereas lower SUCRA scores were associated with better safety. This study has registered with PROSPERO, CRD42023389483.
Results: A total of 25 RCTs, including 7595 patients, were included in this network meta-analysis. PF-00547659 ranked the highest in clinical remission among pure biologics (SUCRA 73.6%) and also ranked third in mucosal healing (SUCRA 74.1%), while adalimumab ranked highest in clinical response (SUCRA 94.9%). Infliximab ranked highest in endoscopy improvement (SUCRA 83.9%). BMS-936557 ranked second lowest in terms of adverse events (30.8% SUCRA) and severe adverse events (20.5% SUCRA).
Conclusion: By indirect comparison, PF-00547659, adalimumab and infliximab were effective biological agents in UC patients. Further studies are required to evaluate their short- and long-term efficacy and safety.
Correlation between skeletal muscle mass to visceral fat area ratio,inflammatory factors, and insulin resistance in patients with type 2 diabetes
Authors: li xiaohua , Tang Si-yun , Li Jing , Wu Hui , Lu Yi-chen , Cao Rui-li , Lu Gu-qin 
Published: May 2023

Abstract
objective To explore the correlation between Skeletal muscle mass and visceral fat area ratio (Skeletal muscle mass to visceral fat area ratio (SVR), neutrophil/lymphocyte ratio (NLR) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM).Methods We investigated the SVR, NLR, and IR in 201 patients with T2DM who visited the Department of Endocrinology of the Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine between June 2022 and March 2023. Appendicular skeletal muscle mass (ASM), total body fat (TBF), visceral fat area (VFA), and basal metabolic volume were measured using multifrequency bioimpedance analysis method. The percentage of body fat to body mass (TBF%), appendicular skeletal muscle mass index (ASMI), and SVR were calculated.Results Patients were divided equally into three groups (Q1–Q3) according to SVR levels. Compared with the Q3 group, in both Q1 and Q2 groups, waist-hip ratio, neutrophils, NLR, fasting blood glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides, total cholesterol, free fatty acid, TBF, TBF%, and VFA were all increased (P < 0.005), whereas lymphocytes, insulin sensitivity index (ISI), ASM, ASMI, basal metabolic rate, and SVR were all decreased (P < 0.005).Conclusion NLR was negatively correlated with ASM, ASMI, SVR, and ISI (P < 0.005) and positively correlated with TBF, TBF%, VFA, and HOMA-IR (P < 0.005). SVR can predict IR in T2DM.
Microperimetric Analysis of Eyes After Macular Hole Surgery With Indocyanine Green Staining: A Retrospective Study
Authors: Jun Sung Yeon , Kong Mingui 
Published: May 2023

Abstract
Background: Indocyanine green (ICG) aids in the visualization of the internal limiting membrane (ILM). Retinal damage from ICG dye toxicity has been reported through in vitro and in vivo studies. However, the clinical toxic effect of ICG during macular surgery has not been functionally evaluated. In this study, we evaluated functional changes in retinal sensitivity associated with ICG toxicity using microperimetry before and after ICG-assisted ILM peeling in patients with macular holes.
Methods: ICG staining was performed only on the macular area below the horizontal line connecting the fovea and optic disc. ILM peeling was performed over the entire macular area inside the vascular arcade. Visual acuity assessment, spectral domain optical coherence tomography, and microperimetry were performed at baseline and one, three, and six months postoperatively. The mean retinal sensitivity of four macular areas was calculated and analyzed.
Results: Eleven eyes were included. Macular holes were successfully closed in all patients. Six months postoperatively, retinal sensitivity improved insignificantly in Area 1 (ICG−/ILM−) and Area 2 (ICG−/ILM+) but decreased in Area 4 (ICG+/ILM−). Three months postoperatively, retinal sensitivity significantly decreased in Area 3 (ICG+/ILM+; 26.63 ± 1.80 vs. 25.52 ± 2.08 dB, p = 0.036). However, the statistical significance of this result was lost six months after the surgery (p = 0.059).
Conclusions: Retinal sensitivity decreased three months after ICG-assisted ILM peeling. However, the statistical significance was lost six months after surgery. ICG staining can be performed with caution during macular hole surgery.
Association between Grandparenting and Cognitive Function in Middle-Aged and Older Chinese: the mediation role of Children’s Intergenerational Support—A nationally representative cohort study
Authors: Hou Xuebei , Luo Yujun , Yang Fen , Zhu Xinhong , Gao Xiaolian , Wang Wenqiang , Qiao Guiyuan , Zhou Jing 
Published: May 2023

Abstract
Objectives
As the world’s population increases in age, the number of people suffering from cognitive impairment and dementia has increased dramatically. This study aims to investigate the association between grandparenting and cognitive function in middle-aged and older Chinese and explore the mediating effects of children’s intergenerational support on grandparenting and cognitive function.
Methods
This study used data from the China Health and Retirement Longitudinal Study (CHARLS). A total of 5882 participants were recruited at the baseline survey in 2011, and 1230 participants completed the follow-up survey over 7 years. The CHARLS included the surveys on grandparenting and cognitive assessments. Grandparenting was categorized as yes and no. Cognitive function was measured by episodic memory and mental intactness. The association between grandparenting and cognitive function was analyzed in cross-sectional and 7-year follow-up models. Finally, the bootstrap method tests the mediating effect of children’s intergenerational support.
Results
Both cross-sectional and longitudinal studies presented that grandparenting was positively related to increase the cognitive function in middle-aged and older Chinese (B = 0.231, p < 0.05; B = 0.217, p < 0.05). Children’s emotional support and economic support played intermediary roles between grandparenting and cognitive function.
Conclusion
The findings emphasize the importance for policymakers to consider the impact of intergenerational care and family support when implementing new policies related to social services for middle-aged and older Chinese.
Agroforestry vs. Agrivoltaic: spectral composition of transmitted radiation and implications for understory crops
Authors: Adolfo Rosati , Kyle Proctor , Azad Dazaea , Maggie Graham , Serkan Ates , Kirschten Haley , Chad Higgins 
Published: May 2023

Abstract

In both agroforestry and agrivoltaics, crops are cultivated under the shade of a top story layer of trees and photovoltaic (PV) panels, respectively. However, the quality (i.e. spectral composition) of the transmitted radiation might differ between the two systems. Tree canopies are green and absorb different spectra selectively, while panels are black and, thus, should not alter the spectral composition of transmitted radiation. Consequently, plant growth and yield may differ depending on the spectral composition of light. In this study, the spectral composition of transmitted radiation (at ground level) was measured with a spectrometer along transects between adjacent rows of trees and PV panels. The transects crossed both sunlit and shaded areas. The radiation transmitted in sunlit areas was nearly identical, qualitatively and quantitatively, to the incident radiation above both systems. However, in the shaded areas transmission was strongly reduced and the spectral composition changed. Under tree canopies the percentage of green (G) and red (R) radiation decreased, while blue (B) and near ultraviolet (NUV) remained similar to the sunlit areas, and far-red (FR) increased sharply. Under the PV panels, both R and FR decreased, G remained similar, while B and NUV increased gradually from the edge of the shade towards the center of the shaded area. This dramatically changed the ratios between different spectra. For instance, the R:FR ratio under the panels varied with the position but remained close to the incoming radiation value (1.35), while under the trees it decreased to 0.35. The R:FR ratio decreased in close correlation (R2 = 0.98) with the fraction of transmitted radiation, under the trees, but not under the panels. The R:B ratio decreased in the shade in both systems, but more so in the panel system. R:G and B:G ratios also changed between and within systems, but less dramatically, while the B:FR ratio decreased at decreasing transmittance under the trees, but increased under the panels. The results indicate that even when transmitted radiation quantity is similar, radiation quality differs substantially between agroforestry and agrivoltaic systems. Possible effects of these changes on understory plant growth and yield are discussed.
The altered composition of gut microbiota and biochemical features as well as dietary patterns in southern Chinese population with recurrent renal calcium oxalate stone
Authors: Cao Cheng , Jin Xiaohua , Ding Qi , Zhu Jin , Yang Dongrong , Fan Bo 
Published: May 2023

Abstract
The correlation between gut microbiota, biochemical features and dietary patterns in recurrent stone formers have been limited investigated in Chinese population.42 patients with calcium oxalate stone (CaOxS group), including 34 recurrent stone formers (RS group), and 40 non-stone healthy subjects (NS group) from Changshu Hospital Affiliated to Soochow University were prospectively recruited. Food frequency questionnaires were completed for participants, fasting vein blood were extracted and 24h urine were collected for biochemical detection, fecal samples were gathered for 16S ribosomal RNA(rRNA) gene sequencing. BMI index, levels of serum triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), magnesium, creatinine and urine magnesium in stone formers were significantly different from controls, and RS patients showed significant low serum phosphate and high urine phosphate status. Celery, bamboo shoots and pickled food were the favored foods of the local stone formers. Patients with recurrent stones had altered composition of microbiota, with Escherichia, Fusobacterium and Epulopiscium being the predominant pathogenic genera. Gut microbiota in RS patients had stronger functions of fatty acid and amino acid degradation, but weaker in their biosynthesis.The pathogenic genera were positively correlated with BMI index, serum TG, creatinine, urine calcium, urine phosphate, urine uric acid (UA), celery, bamboo shoots and pickled food intake. Escherichia and Fusobacterium could predict stone recurrence in combination with serum magnesium and creatinine, with a sensitivity of 74% and specificity of 88%. Our research provided a novel prediction method and prevention strategy for the recurrence of renal calcium oxalate stone in the Han Chinese population in southern China.
Automated construction schedule optimization using Genetic Algorithm
Authors: Srim K. R. , Padmarekha A. , Anandh K. S. 
Published: May 2023

Abstract
Construction project management is a complex process that involves numerous resources and activities that challenges the scheduling of each activity. Effective scheduling is essential for the success of any construction project, but resource allocation conflicts pose a significant challenge for construction managers. This paper proposes a Genetic Algorithm (GA) based model to optimize construction schedules, considering construction resource constraints such as construction activity, construction site, labour, machine, and work timing for labour and machines. The random schedule created with many constraints and parameters will have conflicts in their schedule and cannot be used directly. In this paper, the genetic algorithm uses selection, mutation, and crossover processes to create a new conflict-free schedule until the desired fitness level is reached or the maximum number of iterations is completed. The proposed model is implemented in Python, and the conflict-free schedule is printed as a result. The novelty of this paper is the attempt to apply the job shop scheduling technique for day-to-day construction schedules without conflict using GA. This algorithm can be adapted to optimize the construction schedule for any project and can include additional factors that impact the construction schedule. Overall, this paper provides a valuable contribution to construction project management by presenting an effective optimization model for scheduling construction projects.
Burden of alcohol and other substance use and correlates among undergraduate students at Busitema University in rural Eastern Uganda after COVID-19 lockdown
Authors: Kirabira Joseph , Kagoya Enid Kawala , Mpagi Joseph , Atala Christine Etoko , Ndamanywa Kalisiti , Okibure Ambrose , Kibuuka Ronald , Katongole Fauz , Wandabwa Julius 
Published: May 2023

Abstract
Use of alcohol and other substance remains a major health concern among higher learning institutions. This study aimed at assessing prevalence of alcohol and other substance use among students at Busitema University in Eastern Uganda. A cross sectional survey was conducted among 658 undergraduate students using a questionnaire consisting of Alcohol, Smoking and Substance Involvement Screening Tool and participant sociodemographic and clinical factors. Logistic regression was used to explore the associations. Two hundred sixty-five (40.3%) reported ever using alcohol and 158 (24.0%) had used in last 3 months, while 74 (11.2%) reported ever use of other substances including tobacco, cannabis, cocaine, stimulants sedatives and hallucinogens and 36(5.5%) had used within the recent three months. Recent alcohol use was associated with engaging in romantic relationship (odd ratio(OR) = 1.9, P value (p) = 0.045) while having chronic medical conditions was protective (OR = 0.3, p = 0.031). On the other hand, recent use of other substances was 7 times higher among males (OR = 7.0, p = 0.008) compared to females while fourth year of study was protective (OR = 0.05, p = 0.011). Although alcohol use is a worsening challenge among university students, use of other substances is also highly prevalent after COVID-19 lockdown. Most of the associated factors are modifiable which calls for interventions to address them in order to prevent the likely undesirable outcomes.
Hepatic stellate cell-derived thrombospondin-2 as a novel therapeutic target for liver fibrosis regardless of etiology
Authors: Zhang Ning , Wu Xiaoning , Zhang Wen , Yan Xuzhen , Xu Anjian , Han Qi , Yang Aiting , Chen Wei , You Hong 
Published: May 2023

Abstract
Thrombospondin-2 (THBS2) expression is closely associated with liver fibrosis regardless of etiology. However, the role of THBS2 in the pathogenesis of liver fibrosis has not been elucidated yet. Here we report THBS2 is predominantly expressed in activated HSCs and dynamically increases with liver fibrosis progression and decreased in regression. Selective interference of HSC Thbs2 evidently retards fibrosis progression and intrahepatic inflammatory infiltration in liver fibrosis mouse models. Mechanically, extracellular THBS2, as a dimer, specifically recognizes and directly binds to TLR4 receptor, activating HSCs via stimulating downstream profibrotic focal adhesion kinase (FAK)/transforming growth factor beta (TGF-β) pathways. Disruption of THBS2-TLR4-FAK/TGF-β signaling axis notably alleviates HSC activation and liver fibrosis aggravation. In conclusion, THBS2 plays a crucial role in HSC activation and liver fibrosis progression through TLR4-FAK/TGF-β signaling in an autocrine manner. Therapies targeting HSC Thbs2 via AAV6 vector-capsulated shRNA may represent a novel promising strategy to prevent or treat liver fibrosis.
Bioinspired porous three-coordinated single-atom Fe nanozyme with oxidase-like activity for tumor visual identification via glutathione
Authors: Chen Da , Xia Zhaoming , Guo Zhixiong , Gou Wangyan , Zhao Junlong , Zhou Xuemei , Tan Xiaohe , Li Wenbin , Zhao Shoujie , Tian Zhimin , Qu Yongquan 
Published: May 2023

Abstract
Inspired by structures of natural metalloenzymes, a biomimetic synthetic strategy was developed for scalable synthesis of porous Fe-N3 single atom nanozymes (pFeSAN) using hemoglobin as Fe-source and template. pFeSAN delivered 3.3- and 8791-fold higher oxidase-like activity than Fe-N4 and Fe3O4 nanozymes. The high catalytic performance is attributed to (1) the suppressed aggregation of atomically dispersed Fe; (2) facilitated mass transfer and maximized exposure of active sites for the created mesopores by thermal removal of hemoglobin (2~3 nm); and (3) unique electronic configuration of Fe-N3 for the oxygen-to-water oxidation pathway (analogy with natural cytochrome c oxidase). The pFeSAN was successfully demonstrated for the rapid colorimetric detection of glutathione with a low limit of detection (2.4 nM) and wide range (50 nM–1 mM), and further developed as a real-time, facile, rapid (~6 min) and precise visualization analysis methodology of tumors via glutathione level, showing its potentials for diagnostic and clinic applications.
Mythimna separate herbivory primes Coix resistance in systemic leaves
Authors: Qin Yan , Fan Bo , Zhang Jingxiong , Li Jing 
Published: May 2023

Abstract

Background Coix lacryma-jobi L. belongs to family Poaceae, is widely cultivated in tropic Asian countries for its nutritional and medicinal values. Coix is often threatened by lepidopteran such as Mythimna separata and Ostrinia furnacalis during its life cycle, resulting in severe yield reduction. Insect feeding can trigger defense signaling and increased defense responses in many other crops, yet little is known about whether simulated armyworm feeding on Coix leaves could induce anti-herbivory responses and whether armyworm feeding could activate priming in systemic leaves.Results Mythimna separata simulated herbivory elicited increased jasmonic acid (JA) level, JA-Ile (JA-isoleucine conjugate) and altered transcriptome in the Coix leaves. Meanwhile, M. separata simulated herbivory in local leaves primed the systemic leaves for increased accumulation of jasmonic acid and enhanced resistance to M. separata. Consistently, the response of primed systemic leaves was demonstrated via transcriptome analysis, which were up- or down-regulated comparing with the non-primed systemic leaves.Conclusions In this study, we first reported Mythimna separata simulated herbivory induced increased defense response in systemic leaves of Coix. Mythimna separate herbivory primed Coix resistance in systemic leaves. This study provides new insight into the regulation of defense responses of Coix against M. separata and the ecological function of priming in Coix.