bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissociation of SYNGAP1 Enzymatic and Structural Roles: Intrinsic Excitability and Seizure Susceptibility
Authors: Brill Julia , Clarke Blaise , Hong Ingie , Huganir Richard L. 
Published: January 2025

SYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intellectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a negative regulator of G-protein signaling through its GAP enzymatic activity, SYNGAP1 plays an important structural role through its interaction with post-synaptic density proteins. Here, we reveal that intrinsic excitability deficits and seizure phenotypes in heterozygous Syngap1 knockout (KO) mice are differentially dependent on Syngap1 GAP activity. Cortical excitatory neurons in heterozygous KO mice displayed reduced intrinsic excitability, including lower input resistance, and increased rheobase, a phenotype recapitulated in GAP-deficient Syngap1 mutants. However, seizure severity and susceptibility to pentylenetetrazol (PTZ)-induced seizures were significantly elevated in heterozygous KO mice but unaffected in GAP-deficient mutants, implicating the structural rather than enzymatic role of Syngap1 in seizure regulation. These findings highlight the complex interplay between SYNGAP1 structural and catalytic functions in neuronal physiology and disease.Significance StatementMutations in theSYNGAP1gene are a major cause of intellectual disability, autism, and epilepsy. The SYNGAP1 protein is an important constituent of postsynaptic specializations, and two distinct functions have been characterized: a structural function, carried by its C-terminal PDZ domain, that organizes the composition of the postsynaptic density, and an enzymatic function, in which its GAP domain negatively regulates small GTPases. So far, no electrophysiological/behavioral phenotype of SYNGAP1 has been directly linked to the GAP catalytic activity. Here, we describe that while the GAP catalytic activity does not contribute to the increased seizure susceptibility seen in SYNGAP1 haploin-sufficiency, it does regulate the intrinsic excitability of upper lamina pyramidal cells.
Light dark matter constraints from SuperCDMS HVeV detectors operated underground with an anticoincidence event selection
Authors: Albakry M. F. , Alkhatib I. , Alonso-González D. , Amaral D. W. P. , Anczarski J. , Aralis T. , Aramaki T. , Arnquist I. J. , Ataee Langroudy I. , Azadbakht E. , Bathurst C. , Bhattacharyya R. , Biffl A. J. , Brink P. L. , Buchanan M. , Bunker R. , Cabrera B. , Calkins R. , Cameron R. A. , Cartaro C. , Cerdeño D. G. , Chang Y.-Y. , Chaudhuri M. , Chen J.-H. , Chen R. , Chott N. , Cooley J. , Coombes H. , Cushman P. , Cyna R. , Das S. , De Brienne F. , Dharani S. , di Vacri M. L. , Diamond M. D. , Elwan M. , Fascione E. , Figueroa-Feliciano E. , Fouts K. , Fritts M. , Germond R. , Ghaith M. , Golwala S. R. , Hall J. , Harms S. A. S. , Harris K. , Hassan N. , Hong Z. , Hoppe E. W. , Hsu L. , Huber M. E. , Iyer V. , Jardin D. , Kashyap V. K. S. , Keller S. T. D. , Kelsey M. H. , Kennard K. T. , Kubik A. , Kurinsky N. A. , Lee M. , Leyva J. , Liu J. , Liu Y. , Loer B. , Lopez Asamar E. , Lukens P. , MacFarlane D. B. , Mahapatra R. , Mammo J. S. , Mast N. , Mayer A. J. , Meyer zu Theenhausen H. , Michaud É. , Michielin E. , Mirabolfathi N. , Mirzakhani M. , Mohanty B. , Monteiro D. , Nelson J. , Neog H. , Novati V. , Orrell J. L. , Osborne M. D. , Oser S. M. , Pandey L. , Pandey S. , Partridge R. , Pedreros D. S. , Peng W. , Perna L. , Perry W. L. , Podviianiuk R. , Poudel S. S. , Pradeep A. , Pyle M. , Rau W. , Reid E. , Ren R. , Reynolds T. , Rios M. , Roberts A. , Robinson A. E. , Ryan J. L. , Saab T. , Sadek D. , Sadoulet B. , Sahoo S. P. , Saikia I. , Sander J. , Sattari A. , Schmidt B. , Schnee R. W. , Scorza S. , Serfass B. , Simchony A. , Sincavage D. J. , Sinervo P. , Street J. , Sun H. , Tanner E. , Terry G. D. , Toback D. , Verma S. , Villano A. N. , von Krosigk B. , Watkins S. L. , Wen O. , Williams Z. , Wilson M. J. , Winchell J. , Wykoff K. , Yellin S. , Young B. A. , Yu T. C. , Zatschler B. , Zatschler S. , Zaytsev A. , Zhang E. , Zheng L. , Zuniga A. , Zurowski M. J. 
Published: January 2025

This article presents constraints on dark-matter-electron interactions obtained from the first underground data-taking campaign with multiple SuperCDMS HVeV detectors operated in the same housing. An exposure of 7.63  g−days is used to set upper limits on the dark-matter-electron scattering cross section for dark matter masses between 0.5 and 1000  MeV/c2, as well as upper limits on dark photon kinetic mixing and axionlike particle axioelectric coupling for masses between 1.2 and 23.3  eV/c2. Compared to an earlier HVeV search, sensitivity was improved as a result of an increased overburden of 225 meters of water equivalent, an anticoincidence event selection, and better pile-up rejection. In the case of dark-matter-electron scattering via a heavy mediator, an improvement by up to a factor of 25 in cross section sensitivity was achieved.

Published by the American Physical Society
2025
Modeling kinetic effects of charged vacancies on electromechanical responses of ferroelectrics: Rayleighian approach
Authors: Kumar Rajeev , Zhang Shuaifang , Ganesh P. 
Published: January 2025

Understanding the time-dependent effects of charged vacancies on the electromechanical responses of materials is at the forefront of research for designing materials exhibiting metal-insulator transitions and memristive behavior. A Rayleighian approach is used to develop a model for studying the nonlinear kinetics of the reaction leading to generation of vacancies and electrons via the dissociation of vacancy-electron pairs. Also, diffusion and elastic effects of charged vacancies are considered to model polarization-electric potential and strain-electric potential hysteresis loops. The model captures multiphysics phenomena by introducing couplings among polarization, the electric potential, stress, strain, and concentrations of charged (multivalent) vacancies and electrons (treated as classical negatively charged particles), where the concentrations can vary due to association-dissociation reactions. A derivation of coupled time-dependent equations based on the Rayleighian approach is presented. Three limiting cases of the governing equations are considered, highlighting the effects of (1) nonlinear reaction kinetics on the generation of charged vacancies and electrons, (2) Vegard's law (i.e., the concentration-dependent local strain) on asymmetric strain-electric potential relations, and (3) coupling between a fast component and the slow component of the net polarization on the polarization-electric-field relations. The Rayleighian approach discussed in this work should pave the way for developing a multiscale modeling framework in a thermodynamically consistent manner while capturing multiphysics phenomena in ferroelectric materials.

Published by the American Physical Society
2025
What factors influence the individual’s behavior in engaging in income tax evasion? An investigation using SEM and fsQCA
Authors: Kumar Jitender , Rani Garima , Rani Manju , Rani Vinki 
Published: January 2025

PurposeThe substantial rise in tax evasion raises concerns about its adverse impact on the tax system’s integrity. This article aims to empirically investigate the factors affecting income tax evasion behavior among individuals in India’s National Capital Region (NCR).Design/methodology/approachA cross-sectional design was applied to gather primary data from (N = 548) taxpayers using a “self-administered survey questionnaire.” The hybrid “partial least squares structural equation modeling (PLS-SEM) and fuzzy-set qualitative comparative analysis (fsQCA)” approach was applied to analyze the data.FindingsThis research presents a comprehensive model that explains 53.4% of the variance in behavioral intention and accounts for 51.4% in the actual behavior of individuals who participate in income tax evasion. The outcomes show that high tax burden, corruption and complexity of the tax system significantly influence behavioral intention. On the contrary, digitalization and tax morale insignificantly influence behavioral intention. Notably, behavioral intention is significantly associated with the actual behavior of individuals engaging in income tax evasion.Practical implicationsThe outcomes offer valuable implications for practitioners, including policymakers, governments and tax authorities, to effectively curb income tax evasion behavior and help them make informed decisions.Originality/valueThe innovative research model enhances prevailing knowledge by providing empirical insights into the effect of income tax evasion behavior among individuals in India. This study also contributes methodologically by combining PLS (linear) and fsQCA (nonlinear) techniques, demonstrating that both methodologies offer a deeper comprehension of the factors affecting individual behavior to engage in income tax evasion.
Researching children’s physical environment: a systematic review of research methods
Authors: El-Husseiny Sara , Mansour Yasser , Elrefaie Mohab , El Antably Ahmed 
Published: January 2025

PurposeThe aim is to examine, critique, and synthesize commonly used methodological approaches that capture middle-aged children’s experiences of their physical environments.Design/methodology/approachThe systematic review identified 174 empirical studies from peer-reviewed journals published in English between 2014 and 2023. Fifty-two studies met the inclusion criteria. A thematic analysis (1) identified study characteristics and common methodological approaches, (2) synthesized the literature to reveal major themes and trends, and (3) pointed out significant research gaps.FindingsQualitative methods, combining traditional and participatory approaches, are most effective in capturing children’s spatial experiences. Participatory methods offer more authentic insights and reduce power imbalances compared to traditional methods. Place-based methods, such as child-led walks and participant observations, are particularly valuable for capturing the multidimensional and sensory aspects of children’s interactions with their environments.Research limitations/implicationsThe choice of keywords, selected databases, and the English-language criterion restricted the number of captured reviewed articles that might contribute to the topic.Originality/valueThis systematic review contributes to a deeper understanding of the methodological approaches used in researching middle-aged children’s experiences of their physical environments. It highlights common strategies used with children to communicate their experience of place, identifying the strengths and limitations of each method. Additionally, the review discusses the various aspects of space revealed by different methods.
On the hidden layer-to-layer topology of the representations of reality realised within neural networks
Authors: Gafvert Oliver , Grindrod Peter , Harrington Heather A. , Higham Catherine F. , Higham Desmond J. , Yim Ka Man 
Published: January 2025

PurposeConsider an information processing algorithm that is designed to process an input data object onto an output data object via a number of successive internal {\it layers} and mappings between them. The possible activation state within each layer can be represented as a cube within Euclidean space of a high dimension (e.g. equal to the number of artificial neurons at that level). Multiple instances of such input objects produce a point cloud within each layer’s cube: this is the “representation of the reality” at that layer, as sampled by the set of input objects.Design/methodology/approachMost neural networks reduce the dimension of each layer’s cube from layer to successive layer. This gives the false impression of refining the inner representations of reality, distilling it down to fewer dimensions from which to discriminate or to infer outcomes (whatever is the aim). However, the representation of reality realised within each layer’s cube is a manifold, a curved subset embedded within it and of much lower dimension. Investigations show that such manifolds may not always be reducing in their local dimension. Instead, the manifold may become folded over and over, filling up further dimensions and creating non-realistic (unforeseeable) proximities.FindingsWe discuss some of the likely consequences of these relatively unforeseen characteristics and, in particular, the possible vulnerability of such algorithms to non-realistic perturbations. We consider a possible response to this issue.Practical implicationsNew forms of calibration are necessary, using geometric/topological loss functions, as opposed to simple (variation-limiting) regularisation terms.Originality/valueWe apply persistent homology methods to understand how the images of the point cloud (representing the sampled reality) change as they pass from layer to layer.
Millennial behavioral intentions toward socially responsible investment: an application of norm activation model in a developing country
Authors: Raut Rajdeep Kumar , Kumar Rohit , Das Niladri 
Published: January 2025

Purpose
Sustainable financial practices are integral to achieving the United Nation’s development goals that necessitates the collaborative efforts of both corporate and investors. This study focuses on investors’ pro-environmental personal norms (PN) along with hedonic values on socially responsible investment (SRI) intentions, which could help in understanding investors’ responsiveness to corporate Environmental, Social and Governance efforts.

Design/methodology/approach
The sample for this study included 415 responses from young millennial investors, using a cross-sectional research design. A two-step structural equation model was used to analyze construct reliability and validity and to test the hypotheses and overall model predictability. The mediating role of ascribed responsibility (AR) between the awareness of consequence (AOC) and PNs was investigated.

Findings
These results indicate that AOC and AR substantially affect PNs. PNs based on AOC and AR was found to be significant but scored lower than hedonic considerations for SRI. In addition, the relationship between AOC and PNs exhibited a full mediation effect on AR.

Practical implications
These findings suggest that investors are environmentally conscious when aware of the repercussions of their actions. They feel accountable, even when making financial choices. Fund managers might include more environmentally responsible companies in their portfolios and the government could offer tax incentives to attract investors. The active economic participation of an increasing number of pro-environmental investors can improve the macroeconomic climate.

Originality/value
This is the first study to use the norm activation model for pro-environmental behavior in a financial setting. Most previous studies have focused on social norms to showcase individuals’ obligation and responsibility for a good cause. However, this study demonstrates the importance of personal moral obligation in shaping societal norms. Hedonism is a new dimension in the context of responsible investment.
Joy, sorrow and invisible work and theoretical inconveniences in the labour process of community nurses
Authors: Elliott Lise , Chambers Naomi 
Published: January 2025

PurposeThis paper uses data from an ethnographic study of a group of NHS community nurses in England, to analyse their work using labour process theory. A theory influenced by Marxist thinking, which is concerned with the examination of the labour process. This study of the nurses’ work provides insights into their labour process, as well as proposing theoretical development relating to labour process theory.Design/methodology/approachThe paper has been developed using data from an ethnographically oriented study of a group of community nurses. Data was produced from 140 h of field observations and also semi-structured interviews with six, community nurses. The data produced from field observations and interview transcripts were analysed thematically and theory building was developed inductively.FindingsThe analysis within this paper highlights two areas of the nurses’ work and both illustrate the theoretical difficulties raised, when using labour process as a tool for analysis, as well as its usefulness. These two areas of work are aspects of invisible work and feelings of joy and sorrow; analysis of both these areas supports a theorising of a distinct relationship between nurse and patient. That is, a relationship between worker and human product, which the paper argues should be accommodated within labour process theory.Research limitations/implicationsMore research is required to understand the nature of the proposed social relation in production, particularly with reference to other types of worker, in other caregiving settings. As the demands on healthcare workers and other public sector workers are likely to remain consistently high, improved analytical tools to support research into the nature of caregiving work seem both prudent and timely.Originality/valueLabour process theory is a useful (but often under-used and rather unfashionable) tool in the analysis of service-based, public sector work. This paper proposes a theoretical development within labour process theory, which would recognise a social relation in production between a worker and their human product, based on empirical data from a study of community nurses. This theoretical development has the potential to improve the usefulness of labour process theory in the analysis of caregiving labour.
Toward green purchase behavior: does sustainability become the dominant mare for Lebanese restaurants
Authors: Darwish Ibrahim Mahmoud , Bazzi Ayman Mahmoud , Ali Alaaeldin Abbass 
Published: January 2025

PurposeThe current research seeks to investigate the antecedents of customers’ sustainable purchasing behavior from eco-friendly restaurants located in Lebanon. Moreover, it explores the mediating role of purchase intention on the relationships between pro-environmental antecedents and green purchase behavior. Additionally, it examines the moderating role of willingness to pay premium prices for sustainable products.Design/methodology/approachThe questionnaire technique was used to gather data, and the convenience sample technique was used to select 397 restaurants’ customers.FindingsThe results revealed a positive effect of customers’ green purchase behavior exerted by environmental concern, purchase intention, and willingness to pay premium prices for sustainable products. Also, the findings adopted a significant mediating role of green purchase intention between pro-environmental antecedents and purchase behavior toward green products.Practical implicationsThe current study presents several practical implications for managers and decision-makers. Such as issuing green marketing campaigns on a regular basis to highlight the value of organic food safety, the necessity of using eco-friendly cutlery and the use of renewable energy systems.Originality/valueThis study examined the model pro-environmental antecedents in Lebanon as one of the Middle Eastern developing countries, whereas few studies examined this relationship. Furthermore, this paper contributes by examining the mediating role of green purchase intention.
Assessment of mental health stigma among public safety personnel in Portugal
Authors: Alves Tânia , Madeira Luís 
Published: January 2025

Purpose
This paper aims to assess the presence of mental health stigma among public safety personnel (PSP) in Portugal.

Design/methodology/approach
An online self-administered form was applied, including the Attribution Questionnaire (AQ-9), the Attitudes Towards Mental Health Problems scale (ATMHP) and the socio-demographic characterisation: age, gender, marital status, children, education and geographical location. The sample included police officers, workers of the General Directorate of Reintegration and Prison Services (DGRSP) and workers of the National Institute of Medical Emergency (INEM), as well as a control group (general population).

Findings
In total, 1,441 people participated, of whom 85% were police officers, 3.3% were INEM staff, 2.6% were DGRSP staff and 9.1% were from general population. The most common socio-demographic characteristics were male, married/common-law marriage, two children, 12 years of education and living in Lisbon and Tagus Valley. On AQ-9, all groups showed higher scores on the stigmatizing constructs help, pity and coercion and lower scores on blame, anger, segregation and avoidance. For the total score, the authors found significant differences only in comparison with INEM, who scored lower. The ATMHP showed that INEM and police officers generally had lower total scores than DGRSP and the general population, with the general population having the highest score. There were no significant gender differences for most of the results in both questionnaires.

Originality/value
To the best of the authors’ knowledge, this is the first study assessing mental health stigma among PSP in Portugal. The authors found stigma among PSP, with INEM showing a lower score in stigmatizing attributions, and INEM and police officers showing better attitudes and less shame towards mental illness.
The effect of financial constraints on strategic alliances: agency perspective versus resource dependence perspective
Authors: Lee Min Suk , Thosuwanchot Nongnapat 
Published: January 2025

PurposeThis study examines the effect of financial constraints on firms’ decision to form strategic alliances as a choice of growth strategies. Drawing on agency theory, we argue that financially constrained firms engage in strategic alliances to a greater extent due to the disciplinary role of financial constraints. Nevertheless, financially constrained firms may use strategic alliances as a means to gather more resources from alliance partners. Thus, we further examine agency perspective versus resource dependence perspective through institutional ownership and board size as boundary conditions respectively.Design/methodology/approachWe test our hypotheses on a sample of all publicly traded industrial U.S. firms covering the years 1985–2017 that engaged in strategic alliances.FindingsWe find that financially constrained firms increase strategic alliances. Moreover, high institutional ownership acts as the monitoring mechanism, which weakens the positive association between financial constraints and strategic alliances.Originality/valueThis study provides a better understanding on financially constrained firms’ decision to form strategic alliances by examining the monitoring role of institutional investors and the resource provision role of the board of directors.