bluuebunny/crossref_metadata_2025_split huggingface dataset:
Worries About Philosopher Experts
Authors: Holst Cathrine 
Published: July 2023

AbstractWell-functioning modern democracies depend largely on expert knowledge and expert arrangements, but this expertise reliance also causes severe problems for their legitimacy. Somewhat surprisingly, moral and political philosophers have come to play an increasing role as experts in contemporary policymaking. The paper discusses different epistemic and democratic worries raised by the presence of philosopher experts in contemporary governance, relying on a broad review of existing studies, and suggests measures to alleviate them. It is argued that biases philosophers are vulnerable to may contribute to reducing the quality of their advice, and that the characteristics of philosophers’ expertise, and controversies around what their competences amount to, make it hard to distinguish proper from less proper philosopher experts. Reliance on philosopher experts may also intensify democratic worries not least due to the depoliticization pressures that the introduction of ethics expertise tends to give rise to. Still, philosophers have competences and orientations that policy discussions and democratic deliberations are likely to profit from. Worries about philosopher experts may moreover be mitigated by means of a proper design of expert arrangements. Confronted with the genuine epistemic risks and democratic challenges of contemporary governance any quick fix is obviously unavailable, but when institutionalized in the right way philosophers’ involvement in present-day policymaking bears significant promise.
Direct oral anticoagulants vs vitamin K antagonist on dementia risk in atrial fibrillation: systematic review with meta-analysis
Authors: Branco Diogo R. , Alves Mariana , Severiano E Sousa Catarina , Costa João , Ferreira Joaquim J. , Caldeira Daniel 
Published: July 2023

AbstractOral anticoagulation significantly reduces the incidence of dementia in atrial fibrillation patients. However, this protective effect has not been compared between Direct Oral Anticoagulants (DOAC) and Vitamin K antagonists’ anticoagulants (VKA). We conducted an electronic search for potentially eligible studies through the bibliographic databases MEDLINE, CENTRAL, ClinicalTrials.gov, EMBASE and Web of Science. The outcome of interest was dementia. Random-effects meta-analysis was performed. Nine observational studies were included and 1,175,609 atrial fibrillation patients were enrolled. DOAC therapy was associated with a significant reduction when compared with patients under VKA therapy (hazard ratio 0.89; 95% confidence interval 0.80–0.99). The grade of confidence of our results was very low due to the risk of bias. DOAC therapy is associated with a significant decrease in the risk of dementia when compared with VKA therapy. However, the low certainty of the evidence along with the paucityof clinical trials dedicated to answering this important question underscores a need for global clinical research initiatives.
Iron from Lignite Mining Increases Phosphorus Fixation in Sediments, but Does Not Affect Trophic States of Lakes Along River Spree (Germany)
Authors: Kommana Giulia , Grüneberg Björn , Hupfer Michael 
Published: July 2023

AbstractTo mitigate lake eutrophication, phosphorus (P) availability can be managed by iron (Fe) amendments, which bind P in the water column and settle as Fe oxy-hydroxides. In the fluvial-lacustrine system Spree, Fe oxy-hydroxides enter lakes due to lignite mining in the Lusatian Area (NE Germany). We hypothesized that the amount of P that can be retained from the water column by sediments is positively correlated with their iron content. Column experiments were used to investigate uptake and release of P in the sediments under oxic and anoxic conditions in three downstream lakes (Lake Neuendorfer See, Lake Glower See, Lake Müggelsee) with decreasing mining influence and thus iron loads, and one nearby non-mining-affected lake (Lake Schwielochsee). In lakes interconnected by River Spree, the cumulative P uptake in sediments increased significantly with increasing sedimentary Fe concentrations under both oxic and anoxic conditions. Only the sediments of Lake Glower See had higher P uptake under anoxic than oxic conditions, most likely due to vivianite formation. The net P sedimentation was higher with higher Fe concentration and higher under oxic than anoxic conditions. However, the lakes are classified as eutrophic because although the sediments of the Spree lakes can store further P, this additional P uptake is of little relevance for the P budget in highly P-loaded lakes with short water residence times (10–100 d), as is typical for fluvial-lacustrine systems.
Ethnic Diversity and Social Integration—What are the Consequences of Ethnic Residential Boundaries and Halos for Social Integration in Germany?
Authors: Jünger Stefan , Schaeffer Merlin 
Published: July 2023

AbstractDoes immigration erode the social integration of contemporary mass-scale societies? Continued immigration and corresponding growing ethnic, racial, and religious diversity have prompted this important and highly controversial question. This article gives a brief introduction to the scientific literature on this question and derives from it the following gap that it seeks to address: According to a small number of studies on related but different topics, immigration may be detrimental to social integration if it physically manifests as one of two specific types of ethnic residential segregation. The contested boundaries hypothesis has it that border regions sandwiched between ethnically defined neighborhoods are particularly conflict prone and characterized by increased rates of crime. The halo-effect hypothesis claims that majority members who live in homogenous mainstream neighborhoods that border on ethnically diverse ones (or are even encircled by them) are more likely to vote for right-wing populist parties. In this article, we expand both approaches to the study of social integration in theoretical and empirical terms. With respect to theory building, we discuss why social integration, as indicated by social trust and community attachment, should suffer from these two types of ethnic segregation. To test these claims empirically, we use data from the geo-coded German General Social Survey (ALLBUS/GGSS) 2016 and 2018 that we merge with 100-m × 100‑m spatial grid data from the German Census 2011. These data allow us to apply edge detection techniques to identify ethnic residential boundaries, and our recently developed donut-method to measure ethnic residential halos. To our knowledge our study is the first investigation into the arguably important question whether ethnic residential boundaries and halos erode social integration.
Impact of exosome therapy on pancreatic cancer and its progression
Authors: El-Tanani Mohamed , Nsairat Hamdi , Matalka Ismail I. , Aljabali Alaa A. A. , Mishra Vijay , Mishra Yachana , Naikoo Gowhar A. , Chava Sai Raghuveer , Charbe Nitin B. , Tambuwala Murtaza M. 
Published: July 2023

AbstractPancreatic cancer, one of the most aggressive tumors, has a dismal prognosis because of the low rates of early identification, fast progression, difficulties following surgery, and the ineffectiveness of current oncologic therapies. There are no imaging techniques or biomarkers that can accurately identify, categorize, or predict the biological behavior of this tumor. Exosomes are extracellular vesicles that play a crucial rule in the progression, metastasis, and chemoresistance of pancreatic cancer. They have been verified to be potential biomarkers for pancreatic cancer management. Studying the role of exosomes in pancreatic cancer is substantial. Exosomes are secreted by most eukaryotic cells and participated in intercellular communication. The components of exosomes, including proteins, DNA, mRNA, microRNA, long non-coding RNA, circular RNA, etc., play a crucial role in regulating tumor growth, metastasis, and angiogenesis in the process of cancer development, and can be used as a prognostic marker and/or grading basis for tumor patients. Hereby, in this concise review, we intend to summarize exosomes components and isolation, exosome secretion, function, importance of exosomes in the progression of pancreatic cancer and exosomal miRNAs as possible pancreatic cancer biomarkers. Finally, the application potential of exosomes in the treatment of pancreatic cancer,which provides theoretical supports for using exosomes to serve precise tumor treatment in the clinic, will be discussed.
Preservice physical education teachers’ beliefs about sustainable development in physical education—scale development and validation
Authors: Lohmann Julia , Nigg Carina , Hertle Isabel , Kugelmann Christoph 
Published: July 2023

AbstractClimate change poses a major challenge to people and ecosystems and calls for action across all areas to contribute to a sustainable transformation of society. To shape this transformation, it is crucial that teachers implement education for sustainable development (ESD) in schools for a more sustainable future generation, which also applies to physical education (PE) teachers. However, little is known about PE teachers’ beliefs, a key dimension of professional competence, regarding the implementation of ESD in PE. Hence, the goal of this study was to 1) develop a scale to capture PE teachers’ beliefs about the relevance of sustainable development generally and in the context of PE, and 2) investigate its psychometric properties and criterion validity. The analysis using exploratory structural equation modeling in a cross-sectional sample of 206 preservice teachers resulted in a 10-item instrument with good psychometric properties (comparative fit index [CFI] = 0.976; root mean square error of approximation [RMSEA] = 0.047; standardized root mean square residual [SRMR] = 0.057) and reliability across three factors: a) general beliefs about the relevance of sustainable development, b) positive, and c) critical subject-specific beliefs about sustainable development in PE. Based on the value-belief-norm theory, criterion validity was confirmed through associations between biospheric values and beliefs. We conclude that the newly developed scale is appropriate for assessing PE teacher’s beliefs about the implementation of ESD in PE.
Posing and Solving Modelling Problems—Extending the Modelling Process from a Problem Posing Perspective
Authors: Hartmann Luisa-Marie , Krawitz Janina , Schukajlow Stanislaw 
Published: July 2023

AbstractIn mathematics education, pre-formulated modelling problems are used to teach mathematical modelling. However, in out-of-school scenarios problems have to be identified and posed often first before they can be solved. Despite the ongoing emphasis on the activities involved in solving given modelling problems, little is known about the activities involved in developing and solving own modelling problems and the connection between these activities. To help fill this gap, we explored the modelling process from a problem posing perspective by asking the questions: (1) What activities are involved in developing modelling problems? and (2) What activities are involved in solving self-generated modelling problems? To answer these research questions, we conducted a qualitative study with seven pre-service teachers. The pre-service teachers were asked to pose problems that were based on given real-world situations and to solve their self-generated problems while thinking aloud. We analyzed pre-service teachers’ developing and subsequent solving phases with respect to the problem posing and modelling activities they were engaged in. Based on theories of problem posing and modelling, we developed an integrated process-model of posing and solving own modelling problems and validated it in the present study. The results indicate that posing own modelling problems might foster important modelling activities. The integrated process-model of developing and solving own modelling problems provides the basis for future research on modelling problems from a problem posing perspective.
Multimetal bioremediation from aqueous solution using dead biomass of Mucor sp. NRCC6 derived from detergent manufacturing effluent
Authors: El-Gendy Mervat Morsy Abass Ahmed , Abdel-Moniem Shimaa M. , Ammar Nabila S. , El-Bondkly Ahmed Mohamed Ahmed 
Published: July 2023

AbstractAmong ten metal-tolerant fungal isolates obtained from the microbiomes of detergent industry effluent, Mucor sp. NRCC6 showed the highest tolerance and an adaptive behavior toward the heavy metals Ni2+, Pb2+, Mn2+, and Zn2+. It gave the highest growth rates 0.790 ± 0.59, 0.832 ± 0.32, 0.774 ± 0.40, and 0.741 ± 1.06 mm/h along with the lowest growth inhibition 9.19, 4.37, 11.04, and 14.83% in the presence of Pb2+, Zn2+, Ni2+, and Mn2+, respectively, at a concentration of 5.0 g/L. Then, Mucor sp. NRCC6 was selected as a biotrap for the removal of these heavy metals. The optimized operating conditions were detected to be pH 6.0 for Pb2+, Zn2+, and Mn2+ and pH 5.5 for Ni2+ at 30 °C; agitation speed 150 rpm; contact time 30 min for Mn2+ and Ni2+, 30–60 min for Pb2+, and 90–180 min for Zn2+; NRCC6 biomass dosage 5.0 g/L for Ni2+ and Pb2+ and 10.0 g/L for Mn2+ and Zn2+; and initial concentration 12 mg/L of each ion in the multimetal aqueous solutions. Under these optimized conditions, the adsorption capacity for Pb2+, Ni2+, Mn2+, and Zn2+ reached 98.75, 59.25, 58.33, and 50.83%. The Langmuir isotherm was the best for describing the adsorption of Zn2+ (0.970) and Mn2+ (0.977). The Freundlich isotherm significantly giving a good fit to the adsorption of Pb2+ (0.998) while the adsorption of Ni2+ onto NRCC6 biomass can follow DKR (0.998). Furthermore, the current study revealed that Mucor sp. NRCC6 fungus is a new efficient and eco-friendly method that revealed a maximum removal of 100% for Pb2+ and Zn2+ as well as 97.39, 88.70, 78.95, 74.0, 70.22, 68.57, and 60.0% for Ni2+, Mn2+, Cd2+, Cu2+, Fe3+, As2+, and Cr6+ from the industrial wastewater, respectively.
Modulation of miR-146b by N6-methyladenosine modification remodels tumor-associated macrophages and enhances anti-PD-1 therapy in colorectal cancer
Authors: He Shuying , Song Wen , Cui Shudan , Li Jiating , Jiang Yonghong , Chen Xueqing , Peng Liang 
Published: July 2023

Abstract
Purpose
MicroRNA-146b (miR-146b) alleviates experimental colitis in mice by mediating macrophage polarization and the release of inflammatory factors. Our goals were to evaluate the antitumor efficacy of miR-146b in colorectal cancer (CRC) and to investigate the underlying mechanisms.

Methods
We used murine models of CRC to evaluate whether miR-146b influenced the progression of tumors independent of tumor-associated macrophages (TAMs). RNA immunoprecipitation, N6-methyladenosine (m6A) RNA immunoprecipitation and in vitro pri-miRNA processing assays were conducted to examine whether m6A mediates the maturation of pri-miR-146b/miR-146b. In a series of in vitro and in vivo experiments, we further defined the molecular mechanisms of methyltransferase-like 3 (METTL3)/miR-146b-mediated antitumor immunity and its efficacy in combination with anti-PD-1 immunotherapy.

Results
We found that miR-146b deletion supported tumor progression by increasing the number of alternatively activated (M2) TAMs. Mechanistically, the m6A-related “writer” protein METTL3 and “reader” protein HNRNPA2B1 controlled miR-146b maturation by regulating the m6A modification region of pri-miR-146b. Furthermore, miR-146b deletion promoted the polarization of M2-TAMs by enhancing phosphoinositide 3-kinase (PI3K)/AKT signaling, and this effect was mediated by the class IA PI3K catalytic subunit p110β, which reduced T cell infiltration, aggravated immunosuppression and ultimately promoted tumor progression. METTL3 knockdown or miR-146b deletion induced programmed death ligand 1 (PD-L1) production via the p110β/PI3K/AKT pathway in TAMs and consequently augmented the antitumor activity of anti-PD-1 immunotherapy.

Conclusions
The maturation of pri-miR-146b is m6A-dependent, and miR-146b deletion-mediated TAM differentiation promotes the development of CRC by activating the PI3K/AKT pathway, which induces upregulation of PD-L1 expression, inhibits T cell infiltration into the TME and enhances the antitumor activity of anti-PD-1 immunotherapy. The findings reveal that targeting miR-146b can serve as an adjuvant to anti-PD-1 immunotherapy.

Graphical Abstract
Temporal associations between experiential avoidance and disordered eating behaviors in adolescents and young adults: findings from an epidemiological cohort study with ecological momentary assessment
Authors: Peschel Stephanie K. V. , Fürtjes Sophia , Voss Catharina , Sigrist Christine , Berwanger Johanna , Ollmann Theresa M. , Kische Hanna , Rückert Frank , Koenig Julian , Beesdo-Baum Katja 
Published: July 2023

AbstractPurposePrevious studies linking experiential avoidance (EA) and eating pathology have largely relied on single measurements based on traditional retrospective questionnaires. Taking advantage of available repeated assessments of EA and disordered eating behaviors (DEBs) in the everyday lives of young people from an epidemiological cohort, we aimed to investigate ecologically valid temporal associations between these constructs.MethodsA random population sample of N = 1180 14–21-year-olds from Dresden, Germany, participated at baseline (2015/2016). As part of smartphone-based ecological momentary assessment (EMA), participants reported on engagement in EA and four DEBs (skipping eating, eating large amounts of food, loss-of-control eating, and restrained eating) up to eight times per day for four days. Multilevel modeling of concurrent and time-lagged associations between EA and DEBs, was conducted among those with at least 50% EMA-compliance (n = 1069).ResultsEA was associated with higher concurrent levels of all four types of concurrent DEBs. In addition, EA significantly predicted subsequent levels of restrained eating. Only loss-of-control eating significantly predicted subsequent EA, and this effect depended on the timespan between consecutive assessments. When this timespan was short, higher Loss-of-control eating predicted lower subsequent EA, while it predicted higher subsequent EA when the timespan was longer.ConclusionThe present findings suggest that EA is temporally closely linked to greater engagement in DEBs, supporting theoretical assumptions that DEBs may serve an attempted avoidance function in the context of unpleasant inner experiences. Future studies may benefit from examining samples with more pronounced eating pathology.Level of evidenceLevel IV: Evidence obtained from multiple time series with or without the intervention, such as case studies.
Community attachment as a factor in the subjective well-being of older adults in urban and rural areas: a case study in Tokyo, Osaka, and Shikoku region in Japan
Authors: Seo Yuna 
Published: July 2023

AbstractThis study explored the relationship between community participation/community attachment and subjective well-being (SWB) among Japanese older adults. The study was conducted in Japanese urban (Tokyo and Osaka) and rural (Shikoku region) areas. Structural equation modelling was performed to assess the potential relationship between community participation, community attachment and SWB. Results showed that community participation and community attachment were positively associated in both areas. However, community attachment had a significant impact on SWB only in rural areas with little impact on increasing SWB in urban areas. We conclude that the role of community attachment varies according to regions with different socioeconomic properties. These findings contribute to the design of detailed region-specific initiatives to improve SWB of older adults.
Covariance analysis of periodic and quasi-periodic orbits around Phobos with applications to the Martian Moons eXploration mission
Authors: Ciccarelli Edoardo , Baresi Nicola 
Published: July 2023

AbstractUnderstanding the internal composition of a celestial body is fundamental for formulating theories regarding its origin. Deep knowledge of the distribution of mass under the body’s crust can be achieved by analyzing its moments of inertia and gravity field. In this regard, the two moons of the Martian system have not yet been closely studied and continue to pose questions regarding their origin to the space community; thus, they deserve further characterization. The Martian Moons eXploration mission will be the first of its kind to sample and study Phobos over a prolonged period. This study aims to demonstrate that the adoption of periodic and quasi-periodic retrograde trajectories would be beneficial for the scientific value of the mission. Here, a covariance analysis was implemented to compare the estimation of high-order gravitational field coefficients from different orbital geometries and for different sets of processed observables. It was shown that the adoption of low-altitude non-planar quasi-satellite orbits would help to refine the knowledge of the moon’s libration angle and gravitational field.
Representations of Mathematics Education in Swedish Newspapers—Part of the Structural Influence on Mathematics Teaching
Authors: Grundén Helena , Isberg Jenny 
Published: July 2023

Abstract
There is an ongoing public debate about mathematics education. This dialogue influences policymakers as well as mathematics teachers who are affected by these public ideas. Consequently, exploring the public debate, for example, by studying news media, is relevant for understanding teaching and learning in mathematics and also pertinent for researchers to actively participate in the debate about mathematics education. Representations of mathematics education, which emerged in a study of three national newspapers in Sweden, were explored. Articles relevant to the study were found in systematic searches in a media archive every fifth year between 1992 and 2017. Findings show that the construction of mathematics education in Swedish newspapers is multifaceted and complex, foregrounded by achievements, measurements and various forms of teaching. Other parts of the construction involve teachers wanting to arouse positive feelings, but their attempts are often unsuccessful. Whilst the construction of mathematics education is increasingly varied, the resulting positive and negative feelings and the tensions between representations contribute new insights, which are important to the field.

Résumé
L’enseignement des mathématiques fait constamment l’objet d’un débat public. Cette discussion influence les décideurs politiques ainsi que les enseignants de mathématiques touchés par ces idées échangées dans le domaine public. Par conséquent, afin de comprendre l’enseignement et l’apprentissage des mathématiques, en plus de faciliter la participation active des chercheurs à la conversation portant sur l’enseignement des mathématiques, il est pertinent d’étudier ce débat public, par exemple en examinant les médias d’information. Ainsi, nous avons analysé les représentations faites de l’enseignement des mathématiques qui sont ressorties de l’examen de trois journaux nationaux en Suède. Des recherches systématiques effectuées dans des archives médiatiques tous les cinq ans entre 1992 et 2017 ont permis d’identifier des articles pertinents à cette étude. Les résultats montrent que la conception de l’enseignement des mathématiques dans les journaux suédois est multiforme et complexe, qu’elle met l’accent sur les réalisations, les évaluations et diverses formes d’enseignement. D’autres éléments incluent le fait que les enseignants veulent susciter des sentiments positifs, mais que leurs tentatives sont souvent infructueuses. L’accent placé sur les réalisations et les évaluations est conforme aux études antérieures menées au Canada; alors que la représentation de l’enseignement des mathématiques est de plus en plus variée, les sentiments positifs et négatifs qui en résultent, ainsi que les tensions entre les représentations, apportent de nouvelles perspectives, importantes pour le domaine.