bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitating and Inhibiting Factors regarding Quality of Life in Patients with Multiple Sclerosis: A Qualitative Study
Authors: Homayuni Atefeh 
Published: March 2023

Introduction: Multiple sclerosis (MS) is a chronic progressive disease related to the central nervous system, which affects the patients' quality of life. Several factors play the roles of facilitators and inhibitors concerning the life quality of these patients. This study aims to explain the facilitating and inhibiting factors with regard to the life quality of MS patients.

Methods: The present study was conducted through a conventional content analysis approach. Through purposive sampling and semi-structured interviews, 18 MS patients referring to the Isfahan MS Association were selected. Data collection continued until data saturation was reached. For data management, MAXQDA-10 software was used.
Results: Through content analysis of the interviews, 4 main categories and 15 sub-categories were identified. The main categories included personal facilitators (leisure time and coping strategies), interpersonal facilitators (exercise therapy, social support and social organizations), interpersonal inhibitors (physical problems, psychological disorders, uncertain future, functional limitations, losing job and poverty) ,and environmental inhibitors (disease and treatment process, caregivers' fatigue, insufficient information about MS, family tensions, and fun and entertainment).
Conclusion: According to the results of the current research, by taking measures such as providing educational and psychological services for patients and their caregivers, appropriate insurance coverage, easy access to drugs, especially foreign ones with reasonable tariffs, social and financial support, raising the society's awareness regarding this disease and developing an appropriate urban texture can help to improve the quality of life in MS patients.
Życie prywatne młodych dorosłych. Raport z badań z zakresu socjologii seksualności par i młodzieży
Authors: Giraud Christophe 
Published: March 2023

Artykuł przedstawia przegląd badań socjologicznych, przeprowadzonych we Francji, na temat życia emocjonalnego i seksualnego młodych ludzi. Młodość, początkowo definiowana w odniesieniu do ról dorosłych (osób aktywnych zawodowo, małżonków, rodziców...), była dość negatywnie postrzegana jako okres „latencji”, zawieszenia oczekiwań lub eksperymentowania. Życie intymne młodych ludzi było wówczas interpretowane jako „młodość seksualna” przeplatana pozamałżeńskimi doświadczeniami, powodowanymi niemożnością stabilizacji w związku małżeńskim.
Inne podejście konstruuje młodych ludzi jako zależnych (od ich rodziców) i jednocześnie autonomicznych. Doświadczają oni młodości jako pozytywnego i cenionego okresu osobistego rozwoju. Życie intymne młodych dorosłych można zatem rozumieć jako okres aktywnej socjalizacji, w którym doświadcza się różnych rejestrów związków i nabywa się niezbędnego dla jednostki doświadczenia miłosnego i seksualnego.
Certified Reference Materials for Phase Transition Temperatures of Organic Substances On the Basis of Anhydrous Sodium Acetate and Sodium Methansulfonate
Authors: Shipitsyn A. P. , Nepomiluev A. M. , Tyurnina A. E. 
Published: March 2023

The requirements for thermal analysis instruments are increasing in terms of increasing the measurement ranges and improving their accuracy due to the development of scientific and technological progress in the field of metrological supervision, chemical and pharmaceutical industries. The study of determining the melting point of organic substances is of particular relevance for the metrological support of the applied thermal analysis instruments and traceability to the base units of physical quantities.The purpose of the research was to test the possibility of using organic substances on the basis of sodium acetate and sodium methanesulfonate as phase transition temperatures standards for candidate material to certified reference materials for phase transition temperatures (CRMs) traceable to the SI unit of the «temperature» value.The procedure for measuring the phase transition temperatures (melting point) was performed by differential scanning calorimetry using an STA 449 F5 JUPITER thermal analyzer from the GET 173–2017 State Primary Standard. The determination of the CRM certified value was performed in accordance with GOST ISO Guide 35–2015, the contributions to the uncertainty from the heterogeneity of the starting materials were evaluated, and the short-term and long-term stability of the materials were studied.The obtained metrological characteristics of the investigated batch of CRMs are as follows: the range of permissible certified characteristics of the melting point of the phase transition for anhydrous sodium acetate (328.35–330.35) °C, for sodium methanesulfonate (352.05–354.05) °C. Comparison of the certified melting point values of the developed CRMs with the reference melting point values presented in IUPAC showed that the certified characteristics of the CRMs are consistent within ±1.4 °C.The theoretical significance of the obtained results lies in the proof of the possibility of applying the method of differential scanning calorimetry for the development of certified reference materials for phase transition temperatures (a set of TPKR CRMs) GSO 11928–2022/GSO 11929–2022.The practical significance of the results obtained makes it possible to expand the possibility of establishing and controlling the calibration dependence of thermal analysis measuring instruments; certification of measurement procedures (methods) and accuracy control of the measurement results of the phase transition temperatures of metals, metal salts, metal oxides, polymeric materials, organic and inorganic substances.
Melting Point Certified Reference Materials for Organic Substances: Development Perspectives
Authors: Kazartsev Ya. V. , Korchagina E. N. , Solovev I. V. 
Published: March 2023

The field of the melting point measurements of high-purity organic substances today includes a large number of measuring instruments used in the field of medicine, biology, and the production of perfumery and cosmetic products.The purpose of the research is to identify the features and justify approaches to the development of melting point certified reference materials of organic substances provided with metrological traceability to the SI base measurement units «temperature» (°C).The objectives of the research included justification of the choice of substances-candidates for CRMs; determination of the certification procedure for RMs; establishment of restrictions affecting the certification procedure; estimation of uncertainty for certified values of the melting point CRMs.In the course of the research, a state analysis of metrological assurance in the field of melting point measurements was performed. An overview of the reference complex designed to measure the melting point and purity of organic substances in the range from +40 °C to +250 °C is presented, its functional diagram is given. The basic requirements for substancescandidates for CRMs are identified. The study presents the results of determining the melting point of benzophenone, benzoic acid, succinic acid, anthracene, and caffeine obtained by direct measurements of the phase transition temperature and by indirect measurements based on recording the moment of optical transparency of the substances under study. The results of interlaboratory comparisons on samples of the studied substances are presented, which made it possible to obtain reliable data on the temperature of the emergence of optical transparency at different heating rates. A method for reconciling the results is proposed; it consists in presenting the certified value of the melting point determined by the method of direct measurements of the phase transition temperature in the thermodynamic mode, as well as the certified values of the optical transparency temperature at various heating rates as additional characteristics of the substance in the passports of the developed CRMs. Research objectives for further work are formulated.The theoretical significance of the results obtained lies in the development of theoretical and methodological approaches to the certification of melting point CRMs based on pure organic substances, which make it possible to improve the measurement accuracy in the field of thermal analysis at a higher quality level.
Application of the concept of traceability in determining the mechanical properties of metals under static tension on the example of GSO 11854–2021
Authors: Matveeva I. N. , Tolmachev V. V. , Zabelina A. A. 
Published: March 2023

The article is devoted to the special aspects of application of a certified reference material as a basis for comparison as one of the main tools for ensuring traceability and accuracy control of the measurement results of mechanical properties.In the course of the research, an analysis of the approach of theoretical principles based on GOST 34100.3–2017 / ISO/IEC Guide 98–3:2008 and GOST R ISO 21748–2021 calculation algorithms for evaluating measurement uncertainty was carried out. The methodology of application of the reference material for the mechanical properties of steel grade 20 GSO 11854–2021 for evaluating the uncertainty of the static tensile test results was considered.It was established that evaluating the uncertainty of the static tensile test results to ensure the traceability of the result leads to the need to account the systematic component of the laboratory when calculating the uncertainty of test results, either as a correction or as a contribution to the standard total uncertainty. Two accounting options for the systematic component of the laboratory were proposed.The practical significance of the research is the possibility of applying the model-based approach of theoretical principles based on GOST 34100.3–2017 / ISO / IEC Guide 98–3:2008 and GOST R ISO 21748–2021 calculation algorithms (Equation 1) when evaluating uncertainty according to clause 7.6 of GOST ISO/IEC17025–2019 by accredited laboratories.
Evaluations of Polyacrylamide Water-Based Drilling Fluids for Horizontal Drilling in the Shaly Wolfcamp Formation
Authors: Metwally M. , Nguyen T. , Wiggins H. , Saasen A. , Gipson M. , Yoo H. 
Published: March 2023

Summary
The Permian Basin, located in southeastern New Mexico and west Texas, is treated as the largest province of oil and gas production in the United States (US). The majority of hydrocarbon production from the Permian Basin is from the Wolfcamp shaly formation. Drilling horizontal and extended reached wells is continuously increasing day after day in the Permian Basin. Oil-based mud (OBM) is used to drill these horizontal wells for enhancing shale inhibition, reducing torque and drag, and supporting thermal stability of mud rheology. Due to environmental regulation for limiting use of OBM, the petroleum industry has tried to develop water-based fluid (WBF) that approaches the performance advantages of OBM.
The main objective of this research is to formulate and develop WBF by using polyacrylamide anionic friction reducer (AFR) for drilling the lateral sections of horizontal wells in the shaly Wolfcamp formation. Shale inhibition, barite sagging, lubricity, and thermal stability of the formulated WBF with AFR will be studied to evaluate the developed WBF. Laboratory experiments were conducted to develop and evaluate the performance of the formulated WBF with AFR. The shale inhibition capabilities of the developed WBF with AFR were evaluated by using zeta potential, shale dispersion test, and immersion test.
The results prove the capability of the formulated WBF with AFR to prevent both shale swelling and shale dispersion. AFR limits water penetrations to shale through encapsulation. The mixing procedures of AFR with WBF affect both the thermal stability of mud rheology and shale inhibition. Adding AFR to WBF helps to suspend weighting materials and mitigate barite sag. Besides, AFR decreases torque and drag by decreasing the coefficient of friction (COF). Furthermore, AFR supports enhanced stability of mud rheology with time up to 14 days at temperatures up to 180°F.
The formulated WBF with AFR can be used for enhancing shale inhibition, supporting thermal and time stability of fluid rheology, improving lubricity, and minimizing barite sagging for drilling shaly Wolfcamp formations. This study presents a promising WBF to replace OBM to drill lateral sections in the Permian Basin.
Tobramycin Therapeutic Drug Monitoring in Adult patients with Cystic Fibrosis: Clinical-Based Empiric Dosing versus Model-Informed Precision Dosing
Authors: PRAET Antonin , WDOWIK Juliette , NAVE Viviane , DURUPT Stéphane , REYNAUD Quitterie , NOVE-JOSSERAND Raphaële , DURIEU Isabelle , REIX Philippe , CHARLES Sandrine , BOURGUIGNON Laurent , GOUTELLE Sylvain 
Published: March 2023

Abstract
Background:To inform rational dosing of antibiotics, traditional Therapeutic Drug Monitoring (TDM) with empiric dose adjustment of has been increasingly supplanted by the use of Model-Informed Precision Dosing (MIPD) software.Our objective was to evaluate a model-informed precision dosing approach specifically designed to individualize empiric tobramycin dosing in adults with cystic fibrosis, and to compare target attainment between both the model-based and the empiric dosing approaches. Methods:The BestDose MIPD-software has been used with a published population pharmacokinetic model of tobramycin. To evaluate the MIPD strategy, we used retrospective data from CF adults treated with tobramycin at our local CF center. Empiric dose adjustments from the clinical staff were examined.Using a simulation-based methodology, individualized tobramycin doses that maximize the probability of attaining a Cmax/MIC ratio of 32 mg/L were retrospectively calculated, and compared with empiric dose adjustments. Results:Overall, 101 CF adults were evaluated. Tobramycin Cmax in patients were low (mean of 25.7 ± 5.6 mg/L). The percentage of patients predicted to achieve a Cmax/MIC of ≥ 32 mg/L was low (12.0 %, mean dose of 8.8 ± 1.3 mg/kg) with empiric dose adjustment. TDM with retrospective PK/PD modelling suggest increasing tobramycin dosing in a much larger number of patients (88.0 %, mean dose of 11.6 ± 2.5 mg/kg). Conclusions:Tobramycin doses empirically corrected by clinicians after TDM were predicted to be still insufficient to achieve the efficacy target in most CF patients. Meanwhile a model-based dosing approach that individualizes the tobramycin dosing led to significantly improved achievement of expected target exposure levels in CF adults. Prospective clinical evaluation is warranted.
Vibration Analysis for Turn-Milling Process Monitoring using Empirical Mode Decomposition and Short-Time Fourier Transform
Authors: Susanto Agus , Azka Muizuddin , Arrosida Hanum , Wicaknono Ramadhana Eka 
Published: March 2023

Abstract
Turn-milling is a kind of machining process which widely applied in industries with large-sized workpieces. It is because turn-milling provides advantages for machining large-diameter mechanical parts with high speed, reducing cutting temperature due to the chips being broken, which in turn decreases tool wear. However, it needs to monitor the turn-milling process for preventing the onset of chatter during operation. It is due to the chatter becoming a limitation to productivity, part quality, accelerates tool wear, and machine-tool damage. One of the ways for turn-milling process monitoring is by vibration analysis. Acquired vibrations in the machining process are generally backgrounded by noises and the conventional filtered tools may have defiance for reducing them. It is significant to find signal processing tools for denoising noisy signals before further analysis. This paper presents the utilization of the empirical mode decomposition (EMD) method as an efficient and adaptive noise filter. The Short-Time Fourier Transform (STFT) improvement using EMD is then used for monitoring turn-milling process conditions in the energytime-frequency domain. The results showed that the reconstructed signal was quite impressive compared to the raw signal and the oscillation of the filtered signal was clearer than the raw signal. The improvement of the filtered signals was proved by the kurtosis index and spectral kurtosis. The kurtosis index had been improved 10 – 27 times more than raw signals. The improved STFT using EMD showed a significant spectrum with high resolution compared to conventional STFT. The energy density could be observed clearly in the machining characteristic frequencies with an improvement of about 10-100 times larger. The proposed method is therefore effectively applied to monitor the turn-milling condition.
Polycystic Ovarian Syndrome Awareness among Females in the UAE: A Cross-Sectional Study
Authors: Zaitoun Balkis , Kubaisi Abdullah Al , AlQattan Noora , Alassouli Yahya , Mohamed Alshaimaa , Alameeri Huriya , Mohammed Ghada 
Published: March 2023

Abstract
Background: Polycystic Ovarian Syndrome (PCOS) is a common hormonal disorder affecting females of reproductive age. Clinical guidelines recommend following the diagnostic criteria of PCOS based on an appropriate assessment of the patient’s clinical presentation. Sufficient awareness among the population will prompt females to seek medical attention when necessary. This study aimed to assess knowledge and awareness about PCOS among females above the age of 18 years in the United Arab Emirates (UAE) and to correlate the level of awareness with women's backgrounds, demographics, and education levels.
Methods: This was a cross-sectional study conducted in early 2020. 430 females over the age of 18 years were conveniently selected and interviewed in the UAE using a 21-item questionnaire that assessed participants' awareness of PCOS as a term, its causes, symptoms, complications, treatment, and prevention. 414 entries were eligible for data analysis. IBM® SPSS® Statistics version 25 was used for data entry and analysis.
Results: 349 participants (84.3%) were familiar with the term PCOS. However, only 21.7% of them had sufficient awareness of the syndrome (95% CI = 17.77-25.71%). Being knowledgeable of PCOS was significantly associated with having a previous diagnosis (p=0.002) and with studying or working in a medical field (p<0.001). In addition, females who knew someone diagnosed with PCOS were 5 times more likely to be more aware compared to those who didn’t (95% CI = 2.5-10.8; p<0.001). Age, education level, and nationality showed no correlation with the level of awareness.
Conclusions: Overall, the level of PCOS awareness was insufficient in the study sample. Participants whose source of information was medical practitioners demonstrated more accurate knowledge. Accordingly, awareness of PCOS needs to be raised among females in the UAE, aiding early diagnosis and improving patient-oriented outcomes.
Tacrolimus reverses pemphigus vulgaris serum-enhanced expression of desmoglein in HaCaT cells via inhibition of heat shock protein-27 phosphorylation
Authors: Xie Zhimin , Li Qingqing , Dai Xiangnong , Ye Xingdong 
Published: March 2023

Abstract
Background: Glucocorticoids are the first-line treatment for Pemphigus vulgaris (PV), but its serious side effects can be life-threatening for PV patients. Tacrolimus (FK506) has been reported to have an adjuvant treatment effect against PV. However, the mechanism underlying the inhibitory effect of FK506 on PV-IgG-induced acantholysis is unclear. Objective: The objective of this study was to explore the effect of FK506 on desmoglein (Dsg) expression and cell adhesion in an immortalized human keratinocyte cell line (HaCaT cells) stimulated with PV sera.
Methods: A cell culture model of PV was established by stimulating HaCaT cells with 5% PV sera with or without FK506 and clobetasol propionate (CP) treatment. The effects of PV sera on intercellular junctions and protein levels of p38 mitogen-activated protein kinase (p38MAPK), heat shock protein 27 (HSP27), and Dsg were assayed using western blot analysis, immunofluorescence staining, and a keratinocyte dissociation assay.
Results: PV sera-induced downregulation of Dsg3 was observed in HaCaT cells and was blocked by FK506 and/or CP. Immunofluorescence staining revealed that linear deposits of Dsg3 on the surface of HaCaT cells in the PV sera group disappeared and were replaced by granular and agglomerated fluorescent particles on the cell surface; however, this effect was reversed by FK506 and/or CP treatment. Furthermore, cell dissociation assays showed that FK506 alone or in combination with CP increased cell adhesion in HaCaT cells and ameliorated loss of cell adhesion induced by PV sera. Additionally, FK506 noticeably decreased the PV serum-induced phosphorylation of HSP 27, but had no effect on p38MAPK phosphorylation.
Conclusion: FK506 reverses PV-IgG induced-Dsg depletion and desmosomal dissociation in HaCaT cells, and this effect may be obtained by inhibiting HSP27 phosphorylation.
Estimated Costs for Duchenne Muscular Dystrophy Care in Brazil
Authors: Schneider Nayê Balzan , Roos Erica Caetano , Staub Ana Lúcia Portella , Bevilacqua Isabela Possebon , de Almeida Ana Carolina , Martins Tamiê de Camargo , Ramos Natalia Bergamelli , Loze Priscilla , Saute Jonas Alex Morales , Etges Ana Paula Beck da Silva , Polanczyk Carisi Anne 
Published: March 2023

Abstract
Background: The economic burden of rare diseases on health systems is still not widely measured, with the generation of accurate information about the costs with medical care for subjects with rare diseases being crucial when defining health policies. Duchenne Muscular Dystrophy (DMD) is the most common form of muscular dystrophy, with new technologies recently being studied for its management. Information about the costs related to the disease in Latin America is scarce, and the objective of this study is to evaluate the annual hospital, home care and transportation costs per patient with DMD treatment in Brazil.
Results: Data from 27 patients were included, the median annual cost per patient was R$ 17,121 (IQR R$ 6,786; 25,621). Home care expenditures accounted for 92% of the total costs, followed by hospital costs (6%) and transportation costs (2%). Medications and loss of family, and patient’s productivity are among the most representative consumption items. When disease worsening due to loss of the ability to walk was incorporated to the analysis, it was shown that wheelchair users account for an incremental cost of 23% compared with non-wheelchair users.
Conclusions: This is an original study in Latin America to measure DMD costs using the micro-costing technique. Generating accurate information about costs is crucial to provide health managers with information that could help establish more sustainable policies when deciding upon rare diseases in emerging countries.