bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review of Drug-related Associations Prediction Based on Artificial
Intelligence Methods
Authors: Ma Mei , Lei Xiujuan , Zhang Yuchen 
Published: July 2023

Background:
Predicting drug-related associations is an important task in drug development
and discovery. With the rapid advancement of high-throughput technologies and various biological and
medical data, artificial intelligence (AI), especially progress in machine learning (ML) and deep learning
(DL), has paved a new way for the development of drug-related associations prediction. Many studies
have been conducted in the literature to predict drug-related associations. This study looks at various
computational methods used for drug-related associations prediction with the hope of getting a better
insight into the computational methods used.

Methods:
The various computational methods involved in drug-related associations prediction have
been reviewed in this work. We have first summarized the drug, target, and disease-related mainstream
public datasets. Then, we have discussed existing drug similarity, target similarity, and integrated similarity
measurement approaches and grouped them according to their suitability. We have then comprehensively
investigated drug-related associations and introduced relevant computational methods. Finally,
we have briefly discussed the challenges involved in predicting drug-related associations.

Result:
We discovered that quite a few studies have used implemented ML and DL approaches for
drug-related associations prediction. The key challenges were well noted in constructing datasets with
reasonable negative samples, extracting rich features, and developing powerful prediction models or ensemble
strategies.

Conclusion:
This review presents useful knowledge and future challenges on the subject matter with the
hope of promoting further studies on predicting drug-related associations.
Using the Socioecological Model to Explore Barriers to Health Care Provision in Underserved Communities in the Philippines: Qualitative Study
Authors: Reyes Andrew Thomas , Serafica Reimund , Kawi Jennifer , Fudolig Miguel , Sy Francisco , Leyva Erwin William A , Evangelista Lorraine S 
Published: July 2023

Background
The Philippines’ primary care is delivered via local health centers called barangay health centers (BHCs). Barangays are the most local government units in the Philippines. Designed to promote and prevent disease via basic health care, these BHCs are staffed mainly by barangay health workers (BHWs). However, there has been limited research on the social and environmental factors affecting underserved communities’ access to health care in underserved areas of the Philippines. Given the importance of BHCs in disease prevention and health promotion, it is necessary to identify obstacles to providing their services and initiatives.

Objective
This study aimed to explore multilevel barriers to accessing and providing basic health care in BHCs.

Methods
We used a qualitative approach and the socioecological model as a framework to investigate the multilevel barriers affecting basic health care provision. A total of 18 BHWs from 6 BHCs nationwide participated in focus group interviews. Traditional thematic content analysis was used to analyze the focus group data. After that, we conducted individual semistructured interviews with 4 public health nurses who supervised the BHWs to confirm findings from focus groups as a data source triangulation. The final stage of thematic analysis was conducted using the socioecological model as the framework.

Results
Findings revealed various barriers at the individual (lack of staff motivation and misperceptions of health care needs), interpersonal (lack of training, unprofessional behaviors, and lack of communication), institutional (lack of human resources for health, lack of accountability of staff, unrealistic expectations, and lack of physical space or supplies), community (lack of community support, lack of availability of appropriate resources, and belief in traditional healers), and policy (lack of uniformity in policies and resources and lack of a functional infrastructure) levels.

Conclusions
Examining individual-, interpersonal-, institutional-, community-, and policy-level determinants that affect BHCs can inform community-based health promotion interventions for the country’s underserved communities. Given the multidimensional barriers identified, a comprehensive program must be developed and implemented in collaboration with health care providers, community leaders, local and regional health care department representatives, and policy makers.
Upaya Meningkatkan Kemampuan Membaca Pada Anak-anak kelas 3 - 6 di SDN 1 Mengesta, Desa Mengesta, Tabanan
Authors: Nadi Clarissa Devina , Kurniawan I Gede Agus 
Published: July 2023

Real Work Lecture (KKN) is a form of community service activity with research content that places students off campus and invites students to think critically so that they are able to help develop potential in society with the help of lecturers in solving solutions. The KKN program implemented at SDN 1 Mengesta, Desa Mengesta, Tabanan is a form of education for students at SDN 1 Mengesta who are not yet fluent in reading in a more enjoyable way so that they are interested in being more active in learning to read. The target of this activity is for students in grades 3 to 6 of SD. This is intended so that SD 1 Mengesta students can read and understand long sentences more fluently so that they have no difficulty when they have to read textbooks or answer questions with long sentences. Elementary school students, especially grades 3 to 6, must be able to read fluently and even understand the contents of the reading so that learning at school is more effective and the knowledge gained is more understandable. The role and full support of parents and teachers at school is also very important because it is one of the factors for a child's success at school, in this case also including the ability to read.
====
Kuliah Kerja Nyata (KKN) merupakan bentuk kegiatan pengabdian kepada masyarakat dengan muatan penelitian yang menempatkan mahasiswa di luar kampus dan mengajak mahasiswa berpikir kritis sehingga mampu membantu mengembangkan potensi di masyarakat dengan bantuan dosen dalam pemecahan solusinya. Program KKN yang dilaksanakan di SDN 1 Mengesta, Desa Mengesta, Tabanan merupakan bentuk edukasi kepada siswa/i SDN 1 Mengesta yang belum lancar membaca dengan cara yang lebih menyenangkan sehingga tertarik untuk lebih giat dalam belajar membaca. Sasaran kegiatan ini adalah untuk siswa/i kelas 3 sampai 6 SD. Hal ini bertujuan agar siswa/i SD 1 Mengesta dapat membaca dan memahami kalimat-kalimat panjang dengan lebih lancar sehingga tidak kesulitan saat harus membaca buku pelajaran atau menjawab soal-soal dengan kalimat yang panjang. Siswa/i Sekolah Dasar, terutama kelas 3 sampai 6 SD, harus sudah dapat lancar membaca bahkan memahami isi bacaan sehingga pembelajaran di sekolah lebih efektif dan pengetahuan yang didapat lebih dimengerti. Peran dan dukungan penuh orang tua serta guru di sekolah juga sangat penting karena menjadi salah satu faktor keberhasilan anak di sekolah, dalam hal ini juga termasuk kemampuan membaca.
Estrategias para la motivación en el aprendizaje: ¿Qué opinan estudiantes y maestros?
Authors: Hernández Molano William Andrés , Mahecha Escobar Jenny , Mesa Molano Freddy Heladio 
Published: July 2023

La motivación es un aspecto primordial para el desarrollo de todas las actividades esenciales de la vida, de igual manera lo es para el desarrollo de procesos de enseñanza aprendizaje. Por lo anterior, desde el rol docente se debe estudiar aquello que favorece la motivación intrínseca de los estudiantes, y la de los maestros, ya que estos deben estar involucrados no solo como investigadores sino como objetos de estudio.
Para tener una visión amplia de los factores que influyen en la motivación de los estudiantes se desarrolla un proceso investigativo con educandos y maestros de los niveles educativos: preescolar, básica primaria, básica secundaria, media, y educación superior (pregrado y posgrado). Producto de este estudio se identifican desencadenantes de la motivación como: actividades lúdicas, apoyo familiar, indicadores de proceso, ejercicios innovadores, contenidos contextualizados, establecimiento de logros. Estos hallazgos permiten establecer nuevas orientaciones didácticas que guíen los procesos formativos actuales y futuros.
Structural Equation Modeling in Archival Capital Markets Research: An Empirical Application to Disclosure and Cost of Capital
Authors: Hinson Lisa A. , Utke Steven 
Published: July 2023

ABSTRACT
Structural equation modeling (SEM), an empirical methodology underutilized in archival research, enables researchers to examine paths linking constructs. SEM consists of two components: a measurement model that generates common factors from observed variables and a path model that links the factors. We discuss SEM’s components, estimation, advantages, best practices, and limitations. We illustrate SEM with an application to disclosure research. Unlike some prior research, we find voluntary disclosure quality is negatively associated with cost of capital, both directly and indirectly through information asymmetry, even after controlling for earnings quality’s direct and indirect associations with cost of capital. We believe SEM offers fruitful avenues for future research because it allows flexibility in modeling relations guided by theory, enables tests of underlying theoretical mechanisms, provides tools to address measurement error and missing data, and estimates simultaneous equations. SEM may be useful in settings that currently use path analysis or principal component analysis.
Data Availability: Data used in this study are available from public sources identified in the paper.
JEL Classifications: M41; C30.
Rapid Reduction of HbA1c and Early Worsening of Diabetic Retinopathy: A Real-world Population-Based Study in Subjects With Type 2 Diabetes
Authors: Simó Rafael , Franch-Nadal Josep , Vlacho Bogdan , Real Jordi , Amado Ester , Flores Juana , Mata-Cases Manel , Ortega Emilio , Rigla Mercedes , Vallés Joan-Anton , Hernández Cristina , Mauricio Didac 
Published: July 2023

OBJECTIVE
Early worsening of diabetic retinopathy (EWDR) due to the rapid decrease of blood glucose levels is a concern in diabetes treatment. The aim of the current study is to evaluate whether this is an important issue in subjects with type 2 diabetes with mild or moderate nonproliferative DR (NPDR), who represent the vast majority of subjects with DR attended in primary care.

RESEARCH DESIGN AND METHODS
This is a retrospective nested case-control study of subjects with type 2 diabetes and previous mild or moderate NPDR. Using the SIDIAP (“Sistema d'informació pel Desenvolupament de la Recerca a Atenció Primària”) database, we selected 1,150 individuals with EWDR and 1,150 matched control subjects (DR without EWDR). The main variable analyzed was the magnitude of the reduction of HbA1c in the previous 12 months. The reduction of HbA1c was categorized as rapid (&gt;1.5% reduction in &lt;12 months) or very rapid (&gt;2% in &lt;6 months).

RESULTS
We did not find any significant difference in HbA1c reduction between case and control subjects (0.13 ± 1.21 vs. 0.21 ± 1.18; P = 0.12). HbA1c reduction did not show significant association with worsening of DR, neither in the unadjusted analyses nor in adjusted statistical models that included the main confounding variables: duration of diabetes, baseline HbA1c, presence of hypertension, and antidiabetic drugs. In addition, when stratification by baseline HbA1c was performed, we did not find that those patients with higher levels of HbA1c presented a higher risk to EWDR.

CONCLUSIONS
Our results suggest that the rapid reduction of HbA1c is not associated with progression of mild or moderate NPDR.
Bentuk Pertunjukan Group Gandang Tambua dan Talempong Pacik Sanggar Bukik Junjuang Sirih Nagari Paninggahan Kabupaten Solok
Authors: Nursyam Aan , Nofridayati Nofridayati , Yusnelli Yusnelli , Emridawati Emridawati , Hamzaini Hamzaini 
Published: July 2023

The purpose of this study was to determine and describe the form of performances of the Gandang Tambua and Talempong Pacik music groups at the Bukik Junjuang Sirih Nagari Paninggahan Studio. The research method applied in this research is descriptive qualitative. The result showed that the Gandang Tambua and Talempong Pacik Bukik Junjung Sirih music groups performed at various event and events such as accompanying the Datuk/Pangulu appointment procession, wedding parades (Anak Daro and Marapulai), Qur’an Khatam parades, independence day events and Minangkabau music festival. The performances of the Gandang Tambua and Talempong Pacik groups Bukik Junjung Sirih consisted of several Talempong motifs, namely Cak Dindin, Siamang Tagagau, and several motifs of the Gandang Tambua game, namely Siontong Tabang and Hoyak Tabuik.
Pengembangan Tari Kuda Kepang di Nagari Kurnia Selatan Kecamatan Sungai Rumbai Kabupaten Dharmasraya
Authors: Dwi Setya Primadona Nickse , Asriati Afifah 
Published: July 2023

This study aims to reveal and describe the Development of Braid Horse Dance in Nagari Kurnia Selatan, Sungai Rumbai District, Dharmasraya Regency. This type of research is qualitative research with descriptive methods. The research instrument is the researcher himself and is assisted by supporting instruments such as stationery and cameras. The data in this study used primary data and secondary data. Data collection techniques are carried out by means of literature studies, observations and documentation. The steps to analyze the data are to collect the data, describe the data and infer the data. The results showed that the development of the Braid Horse Dance in South Nagari Kurnia can be seen from the movement, floor pattern, accompaniment music, makeup and clothing, the time and place of the performance. The Braid Horse Dance at Sanggar Ngesti Laras Tirto Kencono has been passed down for generations to 4 generations. The development of Kuda Kepang dance in Nagari Kurnia Selatan which was originally only performed at Wetonan events or selamatan events that occurred from 9 or 10 times a year but can now be performed at various events such as weddings, circumcisions, nagari events and Dharmasraya Regency birthday events.
Regenerasi Eksplan Artemisia annua L. secara In Vitro dengan Perlakuan Sitokinin dan Air Kelapa
Authors: Nitasari Isnaini , Yuliana Farida , Ariyanto Shodiq Eko 
Published: July 2023

Biji Artemisia annua L mempunyai viabilitas sangat rendah sehingga perbanyakan tanaman A. annua dapat dilakukan secara vegetatif melalui kultur in vitro. Salah satu permasalahan untuk meningkatkan regenerasi A. annua dalam kultur in vitro yaitu penggunaan jenis ZPT alami maupun sintetik. Tujuan penelitian ini adalah untuk mengetahui pengaruh sitokinin dan air kelapa terhadap regenerasi eksplan A. annua. Penelitian dilaksanakan bulan Agustus - Oktober 2022 di Laboratorium Kultur Jaringan Universitas Muria Kudus. Penelitian menggunakan metode percobaan observatif dan faktorial yang terdiri dari dua faktor dengan 3 kali ulangan, Percobaan disusun dengan Rancangan Acak Lengkap (RAL). Faktor pertama adalah sitokinin yang terdiri dari empat taraf yaitu: kinetin 0,5 ppm (S1), kinetin 1 ppm (S2), BAP 0,5 ppm (S3), BAP 1 ppm (S4) Faktor kedua adalah air kelapa yang terdiri dari dua taraf yaitu: tanpa penggunaan air kelapa (Ak0) dan air kelapa 10% (Ak1). Hasil penelitian menunjukkan bahwa perlakuan sitokinin dan air kelapa berpengaruh nyata terhadap waktu muncul kalus, diameter kalus, bobot kalus dan jumlah tunas eksplan A. annua. Sitokinin jenis BAP dengan konsentrasi 0,5 ppm menunjukkan hasil tertinggi. Terjadi interaksi nyata antara sitokinin dan air kelapa terhadap waktu muncul kalus dan bobot kalus eksplan A. annua.
KEBIJAKAN KOMISI PENYIARAN INDONESIA DAERAH (KPID) JAWA TENGAH DALAM MELAKUKAN PENGAWASAN TERHADAP PENYELENGGARAAN LEMBAGA PENYIARAN
Authors: Prasetyo Lensa Sylviani , Suparnyo Suparnyo , Sukresno Sukresno 
Published: July 2023

Lembaga Penyiaran Televisi dan Radio sebagai media elektronik dimaksudkan untuk semua segmen masyarakat. Televisi dan Radio berfungsi sebagai media untuk informasi, pendidikan dan hiburan. Keberadaan program yang disiarkan di televisi dan radio sering terjadi pro-kontra di masyarakat, dan seringkali masyarakat mengikuti apa yang dilihat dan apa yang didengar dari acara yang disajikan oleh lembaga penyiaran. Studi ini membahas Kebijakan Komisi Penyiaran Indonesia Daerah (KPID) di Jawa Tengah dalam Mengawasi Pelaksanaan Lembaga Penyiaran. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana tindakan hukum yang dilakukan oleh KPID Jawa Tengah dalam berurusan dengan Lembaga Penyiaran terbukti melanggar konten-konten siaran / program yang disajikan. Metode penelitian ini menggunakan pendekatan yuridis empiris. Hasil Penelitian Kebijakan yang dilakukan oleh KPID Jawa Tengah dalam mengawasi Lembaga Penyiaran dipandu oleh Undang-Undang Penyiaran, dan produk-produk Komisi Penyiaran Indonesia (Pusat) yaitu Peraturan Komisi Penyiaran Indonesia, dalam bentuk Pedoman Perilaku Penyiaran (P3) dan Penyiaran Standar Program (SPS). Hasil analisis Kebijakan KPID tentang Lembaga Penyiaran yang melakukan pelanggaran didasarkan pada isi P3/SPS. Pelanggaran yang paling sering terjadi adalah aturan mengenai iklan yang tidak sesuai untuk usia dewasa sebagaimana Pasal 59 ayat (3) SPS, dan pemutaran lagu yang dilarang dan dibatasi dalam Pasal 20 ayat (1) dan (2), serta tampilan iklan kesaksian yang tidak bisa dipertanggungjawabkan secara ilmiah (menyesatkan). Pada akhirnya, bagi mereka yang terbukti melakukan pelanggaran, KPID memberikan sanksi berupa peringatan tertulis dengan prosedur sesuai dengan peraturan untuk mewujudkan penyiaran yang sehat. Berdasarkan studi di atas dapat disimpulkan bahwa KPID Jawa Tengah perlu terus memantau Lembaga Penyiaran, sehingga program yang disajikan bermanfaat untuk semua kelompok.
Charting the Course for Sustainable Aging: Socio-Environmental and Economic Impacts on Djiboutian Elderly Population
Authors: Aden Kadir , Dirir Sadik Aden 
Published: July 2023

Abstract
The aging population has become a crucial demographic trend worldwide, as it poses both economic and sustainable challenges to governments and societies. And, ostensibly, this unprecedented increase in the senior demographic is currently unfolding in East African nations, primarily, due to substantial advancements in the healthcare system and the commendable support and promotion of education within the region. In this context, the current article examines the relationship between the aging population, ecological footprint, consumption of renewable energy, governmental healthcare expenditures, trade, and urbanization within the context of the Republic of Djibouti. To investigate the data and explore the dynamics and interactions among variables, a comprehensive approach was employed, which involved utilizing an autoregressive distributed lag (ARDL) model, a Granger causality test, and both an impulse response function (IRF) and variance decomposition (VD) analyses. According to the ARDL findings, urbanization has a positive relationship with an aging population. In contrast, the health sector expenditures demonstrated a negative association with the elderly population in Djibouti. This indicates an alarming scenario where government spending on elderly care fails to effectively meet the specific needs of seniors due to insufficient funding, bureaucratic inefficiencies, and inadequate program implementation. Consequently, this leads to a significant gap in coverage for a large portion of the elderly population. On the other hand, it is worth noting that the well-being of the elderly population in Djibouti sees only a slight improvement influenced by the trade performance variable. Nonetheless, this positive impact is somewhat hindered by the lack of sufficient financial inclusion measures that should have ideally been driven by trade-related activities. Moreover, the study’s IRF and VR highlight a positive shock between the consumption of renewable energy and the well-being of the elderly population. Nevertheless, it is of utmost importance to recognize the detrimental impact of the ecological footprint, which significantly undermines the overall well-being of the aging population. Therefore, policymakers must carefully weigh and benefit the simultaneous effect of the advantages of renewable energy consumption on the environment, and on the well-being of the elderly population. It is also essential to emphasize the need to devise more inclusive policies that can comprehensively address this issue and improve the welfare of the elderly demographic.
Phytochemicals from Phillyrea latifolia L. leaves and fruit extracted with various solvents: Their identification and quantification by LC-MS and antihyperglycemic effects
Authors: Aydin Ebru 
Published: July 2023

ABSTRACT

Phillyrea latifolia L. is a type of shrubland, which is widely known as mock privet, and belongs to the Oleaceae family. The objective of this study was to compare and assess the phytochemical composition, antioxidant and antidiabetic activities of ethyl acetate, methanol and aqueous extracts of the fruit and leaves of P. latifolia L. Phenolics were analysed by detecting individual bioactive compounds using an LCMS-2020 quadrupole mass spectrometer and by calculating total phenolic content (TPC). For the first time, the antioxidant and antidiabetic activities of both leaves and fruit were determined using DPPH radical scavenging. The aqueous extract was indicated to have higher antioxidant activities than ethyl acetate and methanol extracts. The individual constituents within the different extracts for both fruit and leaves were detected as the luteolin-7-O-glucoside in the ethyl acetate (854 μg · g–1 and 1,098 μg · g–1), methanol (1,241 μg · g–1 and 2,136.43 μg · g–1) and aqueous (509 μg · g–1 and 898.23 μg · g–1) extracts, respectively. Extractions of ethyl acetate and methanol demonstrated stronger inhibitory activity against human salivary α-amylase than the aqueous extract of both parts of the mock privet. Similarly, extraction of ethyl acetate from the leaves and fruit of the mock privet indicated significantly better inhibitory activity than the methanol and aqueous extracts, respectively, for the inhibition of α-glucosidase activity. This study indicates that both fruit and leaves of mock privet may use as a potential source of natural biomolecules to promote healthy activities.
URGENSI PENDIDIKAN ANTI KORUPSI PADA SEKOLAH MENENGAH KEJURUAN MELALUI SOSIALISASI
Authors: Rasmadi I. P. , Tjukup I. K. , Yustiawan D. G.P. , Sugama I.D. G.D. 
Published: July 2023

Pengabdian masyarakat ini bertujuan untuk mensosialisasikan urgensi pendidikan anti-korupsi didalam proses belajar mengajar yang didalamnya menekankan penerapan nilai dan prinsip anti-korupsi. Kegiatan ini memberikan pemahaman tentang pentingnya mempelajari dan memahami nilai dan prinsip anti-korupsi sebagai usaha preventif didalam memberantas korupsi. Pengabdian kepada masyarakat ini menggunakan data lapangan (field research) untuk mengetahui gejala yang terjadi di masyarakat kemudian menggunakan data kepustakaan (library research) dalam menemukan bahan pengabdian terkait dengan nilai dan prinsip antikorupsi kemudian kegiatan dilakukan menggunakan metode ceramah yang diakhiri dengan diskusi. Hasil dari kegiatan ini siswa mendapatkan pengetahuan baru mengenai upaya preventif pemberantasan korupsi yang mereka bisa terapkan di lingkungan sekolah, rumah dan masyarakat, selain itu guru juga paham tentang peranannya sebagai agen perubahan yang mampu mengembangkan psikologis anak didiknya dengan pendidikan yang sistemik terkait dengan pemberantasan korupsi. Peserta termotifasi untuk menerapkan nilai dan prinsip anti-korupsi pada lingkungan sekolah.

Kata kunci : Sekolah, pendidikan anti-korupsi