bluuebunny/crossref_metadata_2025_split huggingface dataset:
A retrospective analysis of Ayurvedic clinical management of mild COVID-19 patients
Authors: Srivastava Sumit , Singh Harbans , Muralidharan Sanuj , Mohan Rijin , Chaudhary Shikha , Rani Poonam , Payyappalli Unnikrishnan , Srikanth Narayanam 
Published: September 2023

BACKGROUND:
The COVID-19 virus is a new contagious pathogen which has made a huge impact on health, economic and societal perspectives of our country. Early detection, rapid isolation, and adoption of effective infection prevention and control (IPC) measures are key to preventing and controlling COVID-19 infection. Patients are now receiving symptomatic treatment. This retrospective study aims to assess and comprehend the effectiveness of Ayurvedic interventions in the treatment of mild symptomatic COVID-19 patients.

OBJECTIVE:
The objective of this study is to analyze the outcome of Ayurvedic interventions in managing mild symptomatic COVID-19-infected cases.

MATERIALS AND METHODS:
COVID-19 patients (diagnosed through RT-PCR test) admitted at Shri Dhanwantry Ayurvedic College and Hospital, Chandigarh were treated with Ayurvedic interventions. The data were collected and have been analyzed retrospectively. Data collected were systematically analyzed and presented using appropriate software (SPSS version 21).

RESULTS:
The treatment given in this particular study were aimed at dissipating the pathogenesis based on Ayurvedic principles of management. Relief in major clinical symptoms such as fever, cough, and throat pain has been observed in studied cases of COVID-19. The clinical recovery rate observed in this study was 94.3%, which is comparatively high with reference to the current clinical recovery rate, i.e., 69.5% in Chandigarh (India).

CONCLUSION:
The Ayurvedic interventions, AYUSH-64, Agasthya Hareetaki Rasayana, and Anu Taila Nasya, may play a major role in managing mild symptomatic cases of COVID-19.

IEC number:
8-55/2020-CARIRD/TECH/COVID/149
Safety and efficacy of Ayurveda interventions in diabetic retinopathy
Authors: Balakrishnan Praveen , Sumedhan Varsha , Sinimol Thekkekkoottumughath P. , Ahmed Azeem , Venigalla Sridevi , Sudhakar Devarkonda 
Published: September 2023

Introduction:
Diabetic retinopathy (DR), a complication of diabetes mellitus, is a leading cause of blindness on a global level. Nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR), both with and without diabetic macular edema (DME), are the stages of DR. The conventional treatment strategies for DR include intravitreal injections, laser photocoagulation, and surgical approach. There are quite a few individual studies available in various databases showing the efficacy of Ayurveda intervention in DR. However, a systematic review of these studies is not available to date. The aim of this study is to perform a systematic review of various clinical studies of Ayurveda treatments in DR, along with meta-analysis, if possible. This shall help in providing more precise estimates of the effectiveness of management of DR using Ayurveda interventions.

Methods and Analysis:
A systematic review of randomized controlled trials (RCTs), quasi-randomized controlled trials (QRCTs), controlled clinical trials (CCTs), multiple arms clinical trials, and single-group studies on DR published/unpublished from January 1990 to November 2020 will be conducted. The database search will be performed using the words with Boolean operators: Ayurveda OR Ayurvedic AND Diabetic Retinopathy as title, abstract, or keyword. Clinical trials of patients fulfilling the diagnostic criteria based on signs and symptoms of DR in any of its stages, irrespective of age and either gender, will be selected. Studies that are based on the Ayurvedic treatments such as Shodhana (purification therapies), Shamana (pacification therapies), Netra Kriyakalpa (topical ophthalmic application of medications), Moordha Taila Prayoga (topical application of medicine on head), Mukha Kriya Kramas (usage of medicine on/in mouth and on face such as Mukhalepa, Kabala, Gandoosha) irrespective of dosage, type, schedule, drug, form, and advised Pathayapathya (lifestyle changes) as intervention or control will be selected. Response to treatment, both subjective and objective, is the primary outcome and onset of serious adverse events is the secondary outcome.

Ethics and Dissemination:
Ethical approval was obtained from the Institutional Ethics Committee. The results obtained will be published in a peer-reviewed journal.

Trial Registration Number:
International Prospective Register for Systematic Reviews (PROSPERO) number CRD42019136750.
Effect of add-on Ayurveda treatment in the management of chickenpox
Authors: Ekka Ranjita , Dogra Ekta , Nair Parvathy G. , Dixit Amit K. , Choudhary Kuldeep , Das Debajyoti , Prasad Peyyala Vara Venkatesh 
Published: September 2023

BACKGROUND:
Chickenpox is a contagious infection caused by the Varicella-zoster virus with the clinical manifestation of itchy rashes with fluid-filled blisters and fever. Although it is a self-limiting disease, to shorten the recovery period as well as to avoid complications, Ayurveda medicine could be effectively used in the management of chickenpox. In the present case study, the effects of Ayurveda add-on treatment are studied in treating chickenpox and in healing papules.

CLINICAL PRESENTATION AND DIAGNOSIS:
A 38-year-old woman presented to the Out-Patient Department (OPD) of Central Ayurveda Research Institute, Kolkata, with severe itchy and painful papules all over the body and malaise along with difficulty in swallowing because of pain in the throat since 15 days. On the basis of clinical presentation, it was diagnosed as a case of chickenpox.

INTERVENTION AND OUTCOME:
Before visiting the Ayurveda OPD, the patient took allopathic medicine (acyclovir 800 mg TID, paracetamol SOS, and calamine lotion local application) for 15 days, but the disease continued to progress and developed painful lesions with itching and other difficulties. The Ayurveda intervention started after 2 weeks of the onset of the disease. The patient was advised to take Tribhuvankirti Rasa (250 mg BD) before food for 7 days, Haridrakhanda (3 g BD) after food, Panchatiktaghrita (5 mL BD) after food, and Guduchyadi Taila for local application for 15 days.

RESULTS:
Papules of chickenpox were healed in 15 days of the treatment. After taking Ayurveda medicines, the patient got relief from severe itching and pain within 2 days and also completely recovered within 15 days.

CONCLUSION:
Results suggest that the Ayurveda interventions effectively reduced the signs and symptoms of chickenpox and hastened the healing process. It may be concluded that Ayurveda medicines either alone or as add-on give promising therapeutic results in the management of chickenpox.
Integration of Ayurveda and allopathic medicine: Opinion of experts who participated in the working group meetings for the preparation of the WHO benchmarks for the training and practice of Ayurveda
Authors: Berra Jorge Luis 
Published: September 2023

Abstract
The World Health Organization (WHO) has recognized the importance of integrating traditional systems of medicine, including Ayurveda, with conventional medicine, and has taken several initiatives to promote this integration. The Ministry of AYUSH, Government of India, agreed to host two WHO Working Group Meeting that took place at National Institute of Ayurveda (2018) and at Institute of Teaching and Research in Ayurveda (2019) for developing the WHO Benchmarks in Ayurveda with the participation of 27 experts from the six regions of World Health Organization. These WHO Benchmarks on Training and Practice of Ayurveda were published in March 2022. Excluding the author, 23 (89%) of the experts which participated in the said meetings answered a questionnaire about the integration of Ayurveda and allopathic medicine. A very significant majority of these experts (95%) considered that Ayurveda can make important contributions to conventional medicine and are in favor of the integration of Ayurveda and allopathic medicine. There is also a majority consensus that conventional physicians should have training in Ayurveda at both the undergraduate and graduate levels and that they should have training in Ayurvedic remedies. A large proportion of the experts consulted consider the prevailing view in the Ayurvedic government and official environment in India to be in favor of integration with allopathy, and a significant but somewhat smaller number appreciate this same trend in the Ayurvedic academic field of India. It is significant that almost two thirds believe that in the West, Ayurveda should be a specialty within conventional medicine.
Morbidity and treatment costs of cystic fibrosis in a middle-income country
Authors: Hng Shih Ying , Thinakaran Agnes Suganthi , Ooi Chiou Jia , Eg Kah Peng , Thong Meow Keong , Tae Sok Kun , Goh Saw Huan , Chew Kee Seang , Tan Lay Teng , Koh Mia Tuang , Chong Li Ai , Khalid Farah , Ng Ruey Teng , Nathan Anna Marie , de Bruyne Jessie Anne 
Published: September 2023

Abstract

Introduction:
Asian children with cystic fibrosis (CF) managed in Malaysia have significant morbidity with limited access to life-sustaining treatments. We determined the morbidity and treatment cost of CF in a resource-limited country.

Methods:
This cross-sectional study included all children diagnosed with CF in our centre. Data on clinical presentation, genetic mutation, serial spirometry results and complications were collected. Out-of-pocket (OOP) and healthcare costs over 1 year were retrieved for patients who were alive. Cohen’s d and odds ratio (OR) were used to determine the effect size.

Results:
Twenty-four patients were diagnosed with CF. Five patients died at a median (range) age of 18 (0.3–22) years. F508deletion (c. 1521_1523delCTT) was found in 20% of the alleles, while 89% of the variants were detected in nine patients. Body mass index (BMI) Z score was >−1.96 in 70.6% of patients. Two thirds (68%) were colonised with Pseudomonas aeruginosa, and this was associated with lower weight (P = 0.009) and BMI (P = 0.02) Z scores. Only 18% had FEV1 Z scores >−1.96. Early symptom onset (d = 0.74), delayed diagnosis (d = 2.07), a low FEF25–75 Z score (d = 0.82) and a high sweat conductance (d = 1.19) were associated with death. Inpatient cost was mainly from diagnostic tests, while medications contributed to half of the outpatient cost. Healthcare utilisation cost was catastrophic, amounting to 20% of the total income.

Conclusion:
Asian children with CF suffer significant complications such as low weight, low lung function and shortened lifespan. P. aeruginosa colonisation was frequent and associated with poor growth. Healthcare cost to parents was catastrophic.
Approach to headache disorders and the management of migraine: consensus guidelines from the Headache Society of Singapore, first edition (2023)
Authors: Zhao Yi Jing , Idu Jion Yasmin Bte , Ho King Hee , Wong Pei Shieen , Lo Yew Long , Chan Yee Cheun , Ang Lai Lai , Yeo Sow Nam , Soh Soon Beng , Wu Tuck Seng , Yuan Ong Jonathan Jia 
Published: September 2023

AbstractHeadache disorders, particularly migraine, are one of the most common and disabling neurological disorders. There is a need for high-quality, accessible care for patients with headache disorders across all levels of the healthcare system in Singapore. The role of the Headache Society of Singapore is to increase awareness and advance the understanding of these disorders and to advocate for the needs of affected patients. In this first edition of local consensus guidelines, we focus on treatment approaches for headaches and provide consensus recommendations for the management of migraine in adults. The recommendations in these guidelines can be used as a practical tool in routine clinical practice by primary care physicians, neurologists and other healthcare professionals who have a common interest in headache disorders.
Age-related change in AMH in women seeking fertility – a hospital-based study across India
Authors: Murdia Kshitiz , Chandra Vipin , Bhoi Nihar R. , Murdia Nitiz , Aggarwal Ritesh , Shah Naval , Naik Nagadeepti , Nigam Shipra , Puhani Ritu , Suwalka Isha 
Published: September 2023

Objective The emergence of Anti-Mullerian Hormone (AMH) as a reliable biomarker for evaluating ovarian reserve in females indirectly predicting fertility potentials. Related studies contribute to the importance of AMH level tests for ovarian reserve, but limited studies are there to contribute to the geographical distribution of AMH levels in PAN India. This study assessed the age-related change in AMH in the Indian scenario. Design and Setting This is a retrospective hospital-based study. Patient(s) The study included 1,71,595 Indian infertile females visiting different clinics of Indira IVF Hospital Private Limited during the year August 2015 –August 2022 in the age group of 21-50 years. Intervention(s) NA Result(s) The average AMH included in the study was 2.66±1.89 ng/mL. The maximum number of females younger than 30 years had AMH levels of 3.86 ±3.12 ng/mL, and those in older age (31-50 years) group had AMH levels of 2.86 ± 2.7ng/mL. The analysis revealed that AMH levels were negatively correlated with age in all four zones (South, West, East, and North). The correlation coefficients ranged from -0.394 to -0.423, indicating a moderate negative relationship between age and AMH levels. The median AMH levels in the different zones ranged from 1.76 to 2.24 ng/dl. In contrast, the mean AMH levels varied between 2.54±2.75 and 3.03±2.94 ng/dl, indicating some variability in the distribution of AMH levels across the regions. Conclusion(s) The result shows a moderate correlation between females and AMH where r = -0.418 across India. The AMH value shows a sharp fall around 27 years of age.
Descriptive analysis of Rekovelle® “real-world” experience
Authors: Borges Edson , Braga Daniela , Guilherme Patricia , Iaconelli Assumpto , Setti Amanda 
Published: September 2023

Objective(s) To describe the data on “real-world” Rekovelle® administration concerning the response to controlled ovarian stimulation (COS) and clinical intracytoplasmic sperm injection (ICSI) outcomes. Study design This non-interventional study based on secondary use of data included 763 patients undergoing ICSI treatment in a private university-affiliated IVF center from January 2018 to December 2021. Patients undergoing COS with Follitropin delta were given 16mcg Rekovelle® daily (n = 362). Ovarian response to stimulation and laboratory and clinical outcomes of ICSI were described. Two cohorts of patients were added as references: the population included in the ESTHER-1 trial (extern), and a population undergoing COS with follitropin alpha (on-site). Results Patients in the Follitropin delta group showed acceptable outcomes in terms of number of follicles and oocytes, oocyte maturity rate, blastocyst development, and clinical outcomes, irrespective of subgroups of age and BMI. Embryos from women using follitropin delta showed morphokinetic development that seemed equivalent to those from implanted embryos previously reported, demonstrating high implantation potential. This was further corroborated by satisfactory cumulative implantation rates observed for this group of patients. The modified protocol seems to not interfere with oocyte and embryo competence since euploidy rates were also within the expected ranges. OHSS frequencies and rates also seemed acceptable. Conclusions Descriptive data showed that using a starting 16 ug follitropin delta dose for COS results in satisfactory retrieved oocytes and maturity rates across patients in different age ranges and BMI, leading to reasonable cumulative pregnancy rates without increasing OHSS.
Bicornuate uterus with recurrent miscarriage treated with Sitagliptin and PRP: A Case Report of a Successful Pregnancy
Authors: Arjunan Agilan 
Published: September 2023

Research has shown that recurrent miscarriage can be due to loss of endometrial mesenchymal stem-like progenitor cells (eMSC) and excessive decidual senescence. Sitagliptin has been shown to increase eMSC in the endometrial tissue and decrease decidual senescence. Case This is a case report for a 31-year-old woman with a bicornuate uterus who suffered recurrent miscarriages with IVF treatment. IVF treatment was done due to male factor infertility in a modified stimulation protocol using oral clomifene and human menopausal gonadotrophin. A total of 10 blastocysts were cryopreserved. The couple could not afford to do a PGT-A testing on the cryopreserved embryos. Initial three frozen embryo transfers were done in a natural cycle but resulted in biochemical pregnancies. Thyroid function test and Anti-phospholipid Syndrome tests were negative. Her Protein C level was slightly low at 63%. Hysteroscopy showed no abnormalities in both the uterine horns. A fourth embryo transfer was done in a medicated cycle which resulted in no pregnancy. She was started on oral Sitagliptin 100mg once daily for 3 months. Following this, a fifth embryo transfer was done in a natural cycle. Endometrial PRP infusion was done in this cycle. She successfully became pregnant and delivered a baby girl via LSCS in August 2023. Conclusion Sitagliptin can be a cost-effective adjunct treatment for patients with recurrent miscarriage. While the absence of PGT-A may raise questions regarding the underlying cause of her recurrent miscarriages, oral Sitagliptin can be an option in cases of financial constraint or limited resources.
Synergistic Effect of Aluminum Lactate and Sodium Molybdate on Freshwater Corrosion of Carbon Steel Under Irradiation
Authors: Otani Kyohei , Kato Chiaki , Igarashi Takahiro 
Published: September 2023

In this study, a corrosion inhibitor suitable for the corrosion inhibition of primary containment vessels at the Fukushima Daiichi Nuclear Power Station is investigated. Considering the internal environment of the primary containment vessels, the corrosion inhibitor should inhibit the freshwater corrosion of carbon steel under irradiation and should not come under effluent standards in Japan. Herein, a corrosion inhibitor was devised by combining Al lactate and Na molybdate that met the above conditions, and its corrosion mechanism was investigated. It was found that 0.75 mM Al lactate and 0.25 mM Na molybdate were the most inhibitive to the corrosion of carbon steel. As Al lactate has never been reported as a corrosion inhibitor for metallic materials, it could be developed as a novel corrosion inhibitor in this study. The corrosion inhibitor inhibited the freshwater corrosion of carbon steel even under gamma irradiation of 200 Gy/h. Al and molybdate ions in the solution formed a metal cation layer on carbon steel with few defects and without iron. This metal cation layer inhibited both the cathodic oxygen reduction reaction and the anodic iron dissolving reaction, thereby enhancing the corrosion protection of carbon steel in freshwater.
Evaluation of role of mobilizers (ASHA & AWW) on village health and nutrition day (VHND) –Mamta day of study district
Authors: Rathod Mittal , Kaliya Mehul , Prajapati Nilesh , Bundela Chintan , Kotecha Ilesh , Parmar Dipesh 
Published: September 2023

Introduction and Aim: Mamta Abhiyaan is one of the major approaches towards reaching the MDGs of reduction of MMR from present 178 to 100 and IMR from present 42 to 30 in India. Mamta Day is celebrated as an outreach services provision to each single beneficiary at grassroots level. Functionaries of Mamta day are FHW, ASHA, and AWW mainly. ASHA & AWW acts as community personnel which helps in counselling and mobilization for all services provided on Mamta day. The aim of the study was to evaluate the role of ASHA and AWW on VHND (Village health and nutrition day) i.e., Mamata day of study district.

Materials and Methods: Quantitative and qualitative research method, cross sectional study was conducted in rural areas of western Gujarat covering 40 Mamta days. Every participant was clearly explained the purpose of study and their consent was taken. It was an anonymous study using pre structured proforma from available literature.

Results: At 82.5 % sites, AWW was present whereas 77.5% sites ASHA workers were present. At 10 session sites ASHA did not have a due list of any beneficiary. Most sessions were conducted at Anganwadi and sub centre. At all 31 session sites, ASHA was mobilizing beneficiaries to the site; and at 6 (15%) session sites, there was not any mobiliser available. At 30 out of 31 session sites, ASHA was reminding beneficiaries for the next visit. AWW was involved in various services which varied from one session to another.

Conclusion: The presence of all three frontline workers (AWW, ASHA, and ANM) is essential for comprehensive VHND services, but there are notable challenges, including incomplete beneficiary lists and inadequate tracking of left-out children, hampering effective growth monitoring.
Evaluation of hygroscopic cloud seeding in warm-rain processes by a hybrid microphysics scheme using a Weather Research and Forecasting (WRF) model: a real case study
Authors: Lin Kai-I , Chung Kao-Shen , Wang Sheng-Hsiang , Chen Li-Hsin , Liou Yu-Chieng , Lin Pay-Liam , Chang Wei-Yu , Chiu Hsien-Jung , Chang Yi-Hui 
Published: September 2023

Abstract. To evaluate the hygroscopic cloud seeding in reality,
this study develops a hybrid microphysics scheme using a Weather Research and Forecasting (WRF) model, WDM6-NCU (WDM6 modified by National Central University),
which involves 43 bins of seeded cloud condensation nuclei (CCN) in the WDM6 bulk method scheme. This scheme can describe the size distribution of seeded CCN and explain the process of the CCN imbedding and cloud and raindrop formation in detail. Furthermore, based on the observational CCN size distribution applied in the modelling, a series of tests on cloud seeding were conducted during the seeding periods of 21–22 October 2020 with stratocumulus clouds. The model simulation results reveal that seeding in in-cloud regions with an appropriate CCN size distribution can yield greater rainfall and that spreading the seeding agents over an area of 40–60 km2 is the most efficient strategy to create a sufficient precipitation
rate. With regard to the microphysical processes, the main process that
causes the enhancement of precipitation is the strengthening of the
accretion process of raindrops. In addition, hygroscopic particles larger
than 0.4 µm primarily contribute to cloud-seeding effects. The study results could be used as references for model development and warm-cloud-seeding operations.