bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Kualitatif Merkuri Pada Urine Dan Krim Pemutih Wajah Tidak Bermerk Pada Siswi Di SMAN 20 Seram Bagian Barat, Maluku
Authors: Alelo Richardo Reynaldi Sakka , Purwati Purwati 
Published: March 2023

Kulit yang sehat dapat mencerminkan kesehatan seseorang secara keseluruhan. Selain itu, kulit juga menjadi ukuran kecantikan. Keinginan untuk tampil cantik menyebabkan remaja lebih konsumtif terhadap kosmetik demi memudahkan pergaulan dan mendapatkan pengakuan dari lingkungan. Menurut Badan Pengawas Obat dan Makanan (BPOM) dan Departemen Kesehatan (Depkes) sejak tahun 2012, ada bahan berbahaya yang sering ditambahkan pada kosmetika, bahan berbahaya tersebut yaitu merkuri (Hg). Tujuan penelitian ini adalah untuk menganalisis secara kualitatif merkuri pada urine dan krim pemutih wajah tidak bermerk pada siswi di SMAN 20 Seram Bagian Barat, Maluku. Jenis penelitian ini merupakan penelitian deskriptif analitik dengan sampel berjumlah 12 orang siswi dan 12 krim pemutih wajah tidak bermerk yang diambil dengan teknik accidental sampling. Sampel krim pemutih wajah tidak bermerk diperiksa menggunakan Test Kit Mercury secara kualitatif dengan hasil penelitian krim pemutih wajah A positif mengandung merkuri sedangkan krim pemutih wajah B, C, D, E, F, G, H, I, J, K dan L negatif mengandung merkuri. Hasil analisis kualitatif merkuri pada urine siswi menggunakan metode Kalium Iodida 0,5 N dan metode campuran Natrium Sulfat-Kalium Iodida, Tembaga (II) Sulfat didapatkan sampel urine siswi A positif mengandung merkuri sedangkan sampel urine siswi B, C, D, E, F, G, H, I, J, K dan L negatif mengandung merkuri.Â Kata kunci Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â : Merkuri, Krim Pemutih Wajah Tidak Bermerk, Urine
Perancangan Sistem Informasi Manajemen Klinik Berbasis Web Dengan Mengggunakan Metode System Development Life Cycle
Authors: Agustino Rano , Gustiawan Handa , Saputro Moh Ikhsan , Wiyatno Agus 
Published: March 2023

Dalam membangun suatu sistem untuk mendukung manajemen klinik agar dapat mengolah administrasi klinik menjadi tersistem maka hal yang perlu dilakukan terlebih dahulu adalah merancang sistem nya yang sesuai dengan kebutuhan administrasi klinik Pesona Medika. Pada penelitian ini peneliti menggunakan metode System Development Life Cycle (SDLC) untuk metode pengembangan sistem nya sedangkan model nya menggunakan Waterfall, karena penelitian ini lebih berorientasi kepada dokumentasi yang mana dengan model waterfall lebih sesuai untuk keperluan ini. Proses model waterfall terdiri 5 tahapan yangb mana yang pertama adalah Analisa Kebutuhan Sistem. Untuk memenuhi kebutuhan dari analisa kebutuhan sistem pada administrasi klinik maka dibutuhkan kerja sama dari pihak klinik dalam hal ini staff admin atau operator dari klinik untuk menjelaskan dan memberikan dokumen atau data apa saja yang berhubungan dengan proses administrasi nya, proses ini berada di tahapan Analisa Kebutuhan Sistem. Sedangkan untuk bahasa pemrograman dalam membuat website ini dengan menggunakan HTML 5 Sebagai tampilan user nya, sedangkan untuk backen nya menggunakan PHP, sedangkan database yang digunakan Kata Kunci: Sistem Klinik, SI Klinik, SIK.
Acil Serviste SII ve SIRI değerlerinin CO Zehirlenmesinin Şiddetini Tahmin Etmedeki Rolü
Authors: ACAR Tarık , ERTEKİN Birsen 
Published: March 2023

Amaç: Bu çalışmada, başvuru sırasında ölçülen hematolojik parametrelere dayalı indeklerin karbonmonoksit zehirlenmesinin (COZ) şiddetini tahmin etmedeki rolü araştırıldı.
Gereç ve yöntem: 2018 ve 2022 tarihleri arasında bir Eğitim ve Araştırma hastanesi acil servisinde COZ tanısı konulan toplam 183 hasta retrospektif olarak incelendi. Hastaların klinik şiddetini belirlemek için COHb ve laktat düzeyleri kullanıldı. Hastalar hafif-orta karbon monoksit zehirlenmesi (hafif-orta COZ) ve ciddi karbon monoksit zehirlenmesi (ciddi COZ) olarak iki gruba ayrıldı. Sistemik immün inflamasyon indeksi (SII), sistemik inflamatuar cevap indeksi (SIRI) ve sistemik inflamasyon toplam indeksi (AISI), nötrofil/lenfosit oranı (NLR), platelet/lenfosit oranı (PLR) ve monosit/lenfosit oranı (MLR) bu iki hasta grubu arasında karşılaştırıldı.
Bulgular: SII, SIRI, AISI, NLR, PLR ve MLR açısından her iki grup arasında önemli farklılık vardı (p1519.14 iken, sensitivite %67.9 ve spesifite %63.7 idi (AUC: 0.708, p4.955 iken, sensitivite %60 ve spesifite %78.5 olarak bulundu (AUC:0.746, p
The K2 and TESS Synergy. II. Revisiting 26 Systems in the TESS Primary Mission
Authors: Thygesen Erica , Ranshaw Jessica A. , Rodriguez Joseph E. , Vanderburg Andrew , Quinn Samuel N. , Eastman Jason D. , Bieryla Allyson , Latham David W. , Vanderspek Roland K. , Jenkins Jon M. , Caldwell Douglas A. , Ikwut-Ukwa Mma , Colón Knicole D. , Dotson Jessie , Hedges Christina , Collins Karen A. , Calkins Michael L. , Berlind Perry , Esquerdo Gilbert A. 
Published: March 2023

Abstract
The legacy of NASA’s K2 mission has provided hundreds of transiting exoplanets that can be revisited by new and future facilities for further characterization, with a particular focus on studying the atmospheres of these systems. However, the majority of K2-discovered exoplanets have typical uncertainties on future times of transit within the next decade of greater than 4 hr, making observations less practical for many upcoming facilities. Fortunately, NASA’s Transiting Exoplanet Survey Satellite (TESS) mission is reobserving most of the sky, providing the opportunity to update the ephemerides for ∼300 K2 systems. In the second paper of this series, we reanalyze 26 single-planet, K2-discovered systems that were observed in the TESS primary mission by globally fitting their K2 and TESS light curves (including extended mission data where available), along with any archival radial velocity measurements. As a result of the faintness of the K2 sample, 13 systems studied here do not have transits detectable by TESS. In those cases, we refit the K2 light curve and provide updated system parameters. For the 23 systems with M
* ≳ 0.6 M
⊙, we determine the host star parameters using a combination of Gaia parallaxes, spectral energy distribution fits, and MESA Isochrones and Stellar Tracks stellar evolution models. Given the expectation of future TESS extended missions, efforts like the K2 and TESS Synergy project will ensure the accessibility of transiting planets for future characterization while leading to a self-consistent catalog of stellar and planetary parameters for future population efforts.
Mayotte, un territoire riche de ses langues et de ses traditions
Authors: Dehon Marylise , Louguet Amandine 
Published: March 2023

Le Département des études, de la prospective, des statistiques et de la documentation (Deps-doc) a étendu en 2018 aux territoires ultramarins la sixième édition de l’enquête sur les pratiques culturelles. Cette enquête constitue, depuis sa première édition en 1973, le principal instrument de suivi des comportements culturels en France. Elle sert de référence à de nombreuses enquêtes thématiques, monographiques ou territoriales et fait régulièrement l’objet de travaux universitaires. Avec l’extension du champ de l’enquête aux territoires ultramarins, l’édition 2018 est la première à fournir une analyse des pratiques culturelles dans ces territoires et à offrir la possibilité d’analyses régionalisées. Cette enquête a été menée en face-à-face 1 à Mayotte auprès d’un échantillon de plus de 1 200 personnes âgées de 15 ans et plus, entre octobre 2019 et décembre 2019. Les résultats portent donc sur les pratiques culturelles des Mahorais et Mahoraises avant le confinement lié à la pandémie de Covid-19.
Propos introductifs
Authors: Cayol Amandine , Gaillard Émilie 
Published: March 2023

La disparition des corps dans la société actuelle redistribue les cartes du vivre-ensemble. La distanciation sociale, si elle permet une rationalisation certaine des activités humains (travail, soin), n’entraîne-t-elle pas paradoxalement un isolement physique et psychologique ? Par ailleurs, la dissociation à laquelle elle conduit entre le sujet et l’ « e-mage » donnée de lui ne tend-t-elle pas à transformer les relations sociales en un jeu infini où demi vérités, mensonges et illusions produisent de nouveaux rituels et artifices dépendant principalement de la technologie ?
Chapitre 2. Le droit des risques psychosociaux et la distanciation physique au travail
Authors: Russo Sandra 
Published: March 2023

Le Covid 19 a produit un renouvellement des conditions de travail susceptible d’affecter la santé mentale, un risque professionnel que le droit des risques psychosociaux (RPS) contribue à prévenir. L’article met en lien le stress, un des composants de ce droit en formation, et le télétravail, solution de mise à distance des corps physiques. Pour constituer un RPS, le stress doit être pathogène. Une question essentielle se pose : comment l’éviter ? Dans le prolongement, d’une part, des divers fondements du droit des RPS applicables au télétravail, il s’agit, d’autre part, d’apprécier les outils dont disposent les acteurs tenus de veiller à la prévention. Bien que le droit des RPS ne cesse d’évoluer vers plus de sécurité pour la santé mentale, quelques pistes sont proposées pour le cas particulier des télétravailleurs.
Chapitre 6. Identité physique et identité numérique à l’ère de la distanciation sociale
Authors: Mattiussi Julie 
Published: March 2023

La « distanciation sociale » de la crise Covid-19 a mis sur le devant de la scène un phénomène à l’œuvre depuis l’essor du Web : les personnes échangent des biens et des services, s’expriment et se rencontrent de plus en plus sans être présentes physiquement ; les corps disparaissent derrière les écrans. Émerge alors la question de l’identité numérique. Quelle place occupe-t-on sur les réseaux ? Quel contrôle les personnes exercent-elles sur leur image ? Quelle place occupent les écrits dans la définition de cette « image » numérique de soi ? Quelle appréhension de la pluralité des identités qu’une même personne peut avoir en ligne ? Le présent article propose une réflexion sur ces différentes questions en distinguant les identités numériques avec et sans personnes physiques.
L’Amérique dans l’Indo-Pacifique
Authors: Pant Harsh V. , Singh Mann Anant , Briex Gabriel 
Published: March 2023

Les dirigeants américains – de Barack Obama à Joe Biden, en passant par Donald Trump – accordent une importance primordiale à l’Indo-Pacifique. Cette vaste région est vue comme le cœur de la géopolitique mondiale du xxi	e siècle. Il s’agit non seulement d’y faire face aux ambitions de la Chine, mais également de développer les relations avec des acteurs de poids comme l’Inde ou le Japon. Le « pivot » des États-Unis vers l’Indo-Pacifique ne sera pas remis en cause par la guerre en Ukraine.
Pakistan : la double crise politique
Authors: Chaudet Didier 
Published: March 2023

Le Pakistan est confronté à une double crise politique, sur fond de situation économique catastrophique et de regain des violences. À Islamabad, le Premier ministre déchu Imran Khan crie au complot ourdi de l’extérieur et ambitionne de reprendre le pouvoir à son successeur, Shehbaz Sharif. Dans les provinces périphériques, les tensions s’aiguisent au Baloutchistan et dans le Khyber Pakhtunkhwa. En 2023 auront lieu des élections générales : l’année s’annonce lourde de périls.
Parallel T Cell Immunogenic Regions in Influenza B and A Viruses with Distinct Nuclear Export Signal Functions: The Balance between Viral Life Cycle and Immune Escape
Authors: Zhao Yingze , Xiao Wenling , Wu Yanan , Fan Wenhui , Li Lei , Yue Can , Zhang Qingxu , Zhang Danni , Yuan Xiaoju , Yao Sijia , Liu Sai , Li Min , Wang Pengyan , Zhang Hangjie , Zhang Jie , Zhao Min , Zheng Xiaoqun , Liu Wenjun , Gao George F , Liu William J 
Published: March 2023

Abstract
Influenza A viruses (IAVs) and influenza B viruses (IBVs) cause annual epidemics in human populations with seasonal circulation spikes. Peptide AM58–66GL9 located at residues 58–66 of M1 protein of IAVs has been recognized as an immunodominant T cell epitope with HLA-A*0201 restriction and broadly used as a positive reference in influenza immunity. This peptide also almost completely overlaps with a nuclear export signal (NES) 59–68 in IAV M1, which explains the limited escape mutations under the T cell immune pressure in this region. In this study, we investigated the potential immunogenicity and NES in the corresponding region of IBV. The long peptide covering this region can be recognized by specific T cells and induce robust expression of IFN-γ among HLA-B*1501 donors in vivo, but not in HLA-A*0201 donors. Among a series of truncated peptides derived from this region, we identified an immunodominant HLA-B*1501–restricted T cell epitope BM58–66AF9 (ALIGASICF) in the M1 protein of IBV. Furthermore, the structure of the HLA-B*1501/BM58–66AF9 complex shows that BM58–66AF9 performs a flat and featureless conformation that is similar to AM58–66GL9 presented by HLA-A*0201. In contrast with IAV, the sequence around residues 55–70 of IBV M1 does not contain an NES. Our comparative study on IBVs and IAVs provides new insights into the immune and evolution characteristics of IBVs and may shed light on vaccine development for influenza viruses.
Anti-tumor Efficacy of a Bevacizumab Preconditioning followed by Etoposide and Cisplatin Regimen in Human Epidermal Growth Factor Receptor-2-Positive Breast Cancer Brain Metastasis Refractory to Whole Brain Radiotherapy
Authors: Chen Tom Wei-Wu , Lin Ching-Hung , Yeh Dah-Cherng , Tseng Ling-Ming , Rau Kun-Ming , Chen Bang-Bin , Chao Ta-Chung , Huang Shu-Min , Chang Dwan-Ying , Chen I-Chun , Cheng Ann-Lii , Lu Yen-Shen 
Published: March 2023

Background:
For human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer (MBC), treating brain metastasis (BM) remains challenging. We have previously demonstrated that administering bevacizumab 1 day before etoposide and cisplatin (BEEP) can significantly improve antitumor efficacy in cases of breast cancer with BM. Herein, we report the antimetastatic brain tumor efficacy of BEEP in an HER2-positive subpopulation.

Materials and Methods:
Thirty-five MBC patients with BM were enrolled from January 2011 to January 2013. BEEP was given in 21 day cycles: bevacizumab 15 mg/kg on day 1, etoposide 70 mg/m2/day from days 2 to 4, and cisplatin 70 mg/m2 on day 2. The primary endpoint was composite central nervous system (CNS) volumetric objective response rate (ORR). Anti-HER2 treatments were not permitted during the clinical trial.

Results:
A total of 23 patients were HER2-positive, 9 ER-positive, and 14 ER-negative. All had been exposed to trastuzumab; 11 (47.8%) had received lapatinib treatment, and 6 (26.1%) of them had received both lapatinib and capecitabine treatment. Of these, 16 patients (69.6%, 95% confidence interval [CI] 47.1–86.8) achieved CNS-ORR, including 7 (30.4%) with ≥80% and 9 (39.1%) with 50%–80% CNS volumetric reduction. A further 5 patients (21.7%) had 20%–50% CNS volumetric reduction. Median CNS-specific progression-free survival and overall survival were 7.4 (95% CI 5.8–9.0) and 11.8 (95% CI 8.7–14.9) months, respectively. Toxicities were tolerated with granulocyte-colony stimulating factor support.

Conclusion:
The BEEP regimen had a significant antitumor effect in cases of BM of HER2-positive breast cancer that progressed following whole brain radiotherapy.
Comparative study of tocilizumab versus itolizumab in coronavirus disease 2019-infected patients
Authors: Poonam Kumari , Chandni Sinha , Amarjeet Kumar , Ajeet Kumar , Shettru K. Arun , Pavan K. Kandrakonda 
Published: March 2023

Objective
We aimed to compare the effect of tocilizumab and itolizumab in terms of PaO2/FiO2 ratio (P/F ratio), interleukin 6 (IL-6) level, serum ferritin, C-reactive protein, and a reduction in mortality. Our primary objective was to compare P/F ratio at various time intervals: baseline (before administering the drug), 12 h after drug administration, once a day for the next 7 days, and on the 14th day. Our secondary objective was to evaluate serum level of biomarkers like IL-6, ferritin, and C-reactive protein before start of drug infusion and following drug infusion at 72 h and on 7th day.

Patients and methods
A total of 50 patients, age between 18 and 60 years, having moderate Acute Respiratory distress syndrome (ARDS) following coronavirus disease 2019 infection were recruited. Patients of group I received a single dose of injection of tocilizumab 8 mg/kg intravenously (i.v.) via infusion over 1–2 h. Group II patients received premedication with hydrocortisone 100 mg and pheniramine 30 mg and a single dose of injection itolizumab 1.6 mg/kg dissolved in 250 ml of 0.9% normal saline infusion over 5–6 h.

Results
We observed significantly higher P/F ratio in the itolizumab group (239.18±97.31) than in the tocilizumab group (104.87±75.25) on the 3rd day following drug administration (P<0.001). Similarly, the IL-6 level was lower in the itolizumab group (72±100) in comparison with the tocilizumab group (682±1360), and the differences were statistically significant (P<0.05). We identified adverse effects of the drugs in 10 patients who have received itolizumab.

Conclusion
We observed an increasing trend in P/F ratio on the 3rd day following itolizumab administration in comparison with tocilizumab, and the difference was statistically significant (P<0.001).
Serum interleukin-6 as a predictor of the severity of coronavirus disease 2019
Authors: Ahmed Islam M. , Hefny Hesham M. , Ali Amal H. , Refaie Bahaa M. , Abdelal Khalid M. , Taha Elhaisam M. 
Published: March 2023

Background
Inflammatory markers like interleukin-6 (IL-6) are linked to the worse outcome in coronavirus disease 2019 (COVID-19) cases. Other markers such as C-reactive protein are not as reliable as IL-6 in predicting respiratory failure.

Aim
To assess the function of IL-6 as a predictor of COVID-19 severity.

Patients and methods
A total of 50 severe and critical patients with PCR-confirmed COVID-19 were included. All enrolled patients followed the case definition for confirmed cases of Egyptian national protocol for COVID-19 issued by MOHP. Clinical assessment, imaging, and laboratory data were recorded at admission. Pulmonary function was evaluated by SpO2/FiO2 ratio. Outcomes included hospital stay, prognosis of the disease, complications, death rate, and discharge, which were recorded during the follow-up.

Results
The elevated IL-6 group showed a significantly higher critical rate (87.1%) than the normal IL-6 group (26.3%) (P<0.0001), and the improvement rate was higher in the normal IL-6 group (73.7%). Moreover, the death rate was significantly greater in the elevated IL-6 group (38.7%) than the normal IL-6 group (10.5%) (P=0.033). The cutoff value of IL-6 levels in prediction of severity and mortality of COVID-19 was assessed. Our receiver operating characteristic results revealed that IL-6 cutoff value is higher than 50.27 for severity and the cutoff value is greater than 120.83 for mortality. The sensitivity values of IL-6 for severity and mortality were 93.3 and 90.5%, respectively, and the specificity values were 90.0 and 86.7%, respectively.

Conclusion
Elevated levels of serum IL-6 in COVID-19-infected patients were related with a variety of adverse outcomes, including severe illness, mechanical ventilation, and acute respiratory distress syndrome. When it came to accurately predicting the severity and mortality of COVID-19, the optimum IL-6 cutoff levels were 50.27 and 120.83 pg/ml, respectively.
Renal resistive index as a predictor of hemodialysis and mortality risk in septic patients developing acute kidney injury
Authors: Nour Islam A. , Eldehily Khalaf I. , Abd Elbaset Ahmed S. , Saber Hamdy M. 
Published: March 2023

Introduction
Mechanisms of acute kidney injury (AKI) comprise renal hypoperfusion, intrarenal vasoconstriction, inflammation, oxidative stress, and nephrotoxicity. An important pathophysiological pathway includes intrarenal vasoconstriction and endothelial damage of the microvessel, leading to impaired macrovascular and microvascular flow, which further aggravates ischemia. Nowadays, Doppler ultrasound is rapidly gaining ground as a screening tool in critically ill patients. The performance of cardiac, lung, and abdominal ultrasound in patients after cardiac arrest, major operations, and during shock has become the standard policy. However, renal ultrasound, which could be easily incorporated in this screening, is not commonly performed.

Aim
To test the ability of renal resistive index (RRI) measurement by Doppler ultrasound to predict the development of AKI in septic patients and find a relation with the progression to persistent renal impairment and relation to outcome and mortality.

Patients and methods
A total of 40 septic patients with AKI were randomized and subjected to RRI measurements, on admission and after 48 h, and the patients were followed till hospital discharge to detect the correlation to outcome. Mortality risk assessment was measured by the APACHE III score.

Results
There was a statistically significant increase of RRI in cases with persistent AKI in comparison with cases with transient AKI (P<0.05). There was a statistically significant increase in APACHE III score in patients with high RI (P<0.005).

Conclusion
Renal Doppler RI may be a promising tool for predicting the risk of developing AKI in acutely ill septic patients and may help in predicting the reversibility of AKI. High RRI values in septic patients with AKI are independently related to ICU mortality and persistent renal dysfunction at discharge from ICU.
Comparative study lumbar plexus block and lumbar erector spinae plane block for postoperative pain relief after proximal femoral nail for proximal femoral fractures
Authors: Diwan Sandeep , Lonikar Abhishek , Dongre Himaunshu , Sancheti Parag , Nair Abhijit S. , Panchawagh Suhrud 
Published: March 2023

ABSTRACT

Background:
The clinical outcomes (time to ambulation, length of stay, and home discharge) after proximal femoral nail (PFN) for proximal femoral fractures (PFF) is dependent on successful pain management. Currently, the lumbar erector spinae plane block (LESPB) is in vogue and is associated with favorable outcomes in the postoperative period. Our study aimed to evaluate whether a LESPB provided equivalent analgesia and clinical outcomes as compared to LPB in PFN for PFF.

Material and Methods:
We compared LPBs [L] with LESPBs [E], with 30 patients in each group, performed from June 2020 to June 2021 for PFN in PFF's. The primary outcome of this study was the average NRS pain scores over 24 hours postoperatively. Secondary outcomes included pain scores at different time points over 24 hours, opioid consumption between the groups at 24 hours postoperatively, time for request of first parenteral analgesia, quadriceps weakness and adverse events.

Results:
The average pain scores over 24 hours were better in the LESPB group as compared to the LPB group (p = 0.02). Further, only n = 5 (30%) of patients in the LESPB group required opioids, while n = 13 (43.333%) of patients in the LPB group required opioids. Moreover, the median time for request of first parenteral analgesia was 615 (480–975) minutes, weakness of quadriceps function occurred in 2 patients in the L group, which recovered at 3rd and 5th month, respectively, with no incidences of hemodynamic instability and respiratory complications.

Conclusions:
This trial demonstrated that single bolus LESPB is superior to LPB in terms of analgesic outcomes, has low adverse events, and is an agreeable substitute for patients with PFF undergoing a PFN.