bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inference in difference‐in‐differences: How much should we trust in independent clusters?
Authors: Ferman Bruno 
Published: January 2023

SummaryWe analyze the challenges for inference in difference‐in‐differences (DID) when there is spatial correlation. We present novel theoretical insights and empirical evidence on the settings in which ignoring spatial correlation should lead to more or less distortions in DID applications. We show that details, such as the time frame used in the estimation, the choice of the treated and control groups, and the choice of the estimator, are key determinants of distortions due to spatial correlation. We also analyze the feasibility and trade‐offs involved in a series of alternatives to take spatial correlation into account. Given that, we provide relevant recommendations for applied researchers on how to mitigate and assess the possibility of inference distortions due to spatial correlation.
Optical coherence tomography angiography with adaptive multi‐time interval
Authors: He Bin , Zhang Yuxin , Meng Zhe , He Zhijun , Wang Chengming , Chen Zhenyu , Yin Zichen , Hu Zhangwei , Shi Yejiong , Zhang Ning , Zhang Wenxin , Wang Guihuai , Xue Ping 
Published: January 2023

AbstractOptical coherence tomography angiography (OCTA) can provide in vivo three‐dimensional microvasculature information of bio‐tissues, but it is sensitive to motion and time‐consuming. To overcome these limitations, we propose an adaptive multiple time interval correlation mapping OCTA with a time‐efficient scanning protocol and motion compensation algorithms. A spectral‐domain OCT with a center wavelength of 850 nm, A‐scan rate of 120 kHz and spatial resolution of 4.1 μm (axial) × 6.9 μm (lateral) is built to reconstruct the microvascular networks in the human arm. By adaptive optimization of the weights of different time interval B‐scan angiograms, our novel OCTA technique achieves better performance with a visible vascular density increase of ~67% and a signal‐to‐noise ratio enhancement of ~11.6%.
Energy transfer between Si nanocrystals and protoporphyrin molecules as a function of distance, orientation and size
Authors: Koliogiorgos Athanasios , Polcar Tomas , Rezek Bohuslav 
Published: January 2023

AbstractThe interaction between protoporphyrin molecules (donor) and Si nanocrystals (acceptor) up to 2.5 nm for varying distances and orientations is studied by DFT, semi‐empirical and TDDFT methods. Simulations show an effect on electronic structure, indicative of electron charge transfer in parallel orientation and small distances and nonelectron energy transfer for different orientations and larger distances. An absorption‐emission spectral overlap is observed. The calculations of coupling and energy transfer rates show a distance dependence typical of fluorescence resonance energy transfer (FRET) in the long range, while in the short and ultra‐short range the distance dependence indicates electron transfer in addition to FRET. The Si NCs with the smallest size yield larger couplings than the larger nanocrystals. The PPIX/Si NC coupling was enhanced by adding a plasmon nanoparticle as a bridge in the donor‐acceptor system. Results using Au nanoparticles show increased energy transfer rates up to 104 and lower distance dependence.
Clinical genetic counseling and translation considerations for polygenic scores in personalized risk assessments: A Practice Resource from the National Society of Genetic Counselors
Authors: Wand Hannah , Kalia Sarah S. , Helm Benjamin M. , Suckiel Sabrina A. , Brockman Deanna , Vriesen Natalie , Goudar Ranjit K. , Austin Jehannine , Yanes Tatiane 
Published: January 2023

AbstractPolygenic scores (PGS) are primed for use in personalized risk assessments for common, complex conditions and population health screening. Although there is growing evidence supporting the clinical validity of these scores in certain diseases, presently, there is no consensus on best practices for constructing PGS or demonstrated clinical utility in practice. Despite these evidence gaps, individuals can access their PGS information through commercial entities, research programs, and clinical programs. This prompts the immediate need for educational resources for clinicians encountering PGS information in clinical practice. This practice resource is intended to increase genetic counselors' and other healthcare providers' understanding and comfort with PGS used in personalized risk assessments. Drawing on best practices in clinical genomics, we discuss the unique considerations for polygenic‐based (1) testing, (2) clinical genetic counseling, and (3) translation to population health services. This practice resource outlines the emerging uses of PGS, as well as the critical limitations of this technology that need to be addressed before wide‐scale implementation.
Explaining obesity disparities by urbanicity, 2006 to 2016: A decomposition analysis
Authors: Zang Emma , Flores Morales Josefina , Luo Liying , Baid Drishti 
Published: January 2023

AbstractObjectiveA large, and potentially growing, disparity in obesity prevalence exists between large central metros and less urban United States counties. This study examines its key predictors.MethodsUsing a rich county‐year data set spanning 2006 to 2016, the authors conducted a Gelbach decomposition to examine the relative importance of demographic, socioeconomic, environmental, and behavioral factors in shaping the baseline obesity gap and the growth rate over time between large central metros and other counties.ResultsPredictors included in this model explain almost the entire obesity gap between large central metros and other counties in the baseline year but can explain only ~32% of the growing gap. At baseline, demographic predictors explain more than half the obesity gap, and socioeconomic and behavioral predictors explain the other half. Behavioral and socioeconomic predictors explain more than half the growing gap over time whereas controlling for environmental and demographic predictors decreases the obesity gap by urbanicity over time.ConclusionsResults suggest policy makers should prioritize interventions targeting health behaviors of residents in non‐large central metros to slow the growth of the obesity gap between large central metros and other counties. However, to fundamentally eliminate the obesity gap, in addition to improving health behaviors, policies addressing socioeconomic inequalities are needed.
Structural design optimization of CFRP/Al hybrid co‐cured high‐speed flywheel with the particle swarm optimization algorithm
Authors: Zhong Bingfu , Li Junli , Cai Xiaojiang , Chen Tao , An Qinglong , Chen Ming 
Published: January 2023

AbstractWith the development of CFRP materials and co‐cured structure, CFRP/Al hybrid co‐cured materials have been widely used for high‐speed energy storage flywheels. Therefore, it has become a hot research topic, which is to design a CFRP/Al hybrid co‐cured flywheel with a reasonable structure. In this paper, a particle swarm optimization algorithm is presented for improving the energy storage density to optimize the structure of the CFRP/Al hybrid co‐cured high‐speed flywheel. First, the stress and structural analysis of the flywheel are carried out based on energy storage. The inner‐radius‐to‐outer‐radius and the radial wall thickness h are chosen as the objective function because the and h are the factors which influence the energy storage density of the flywheel. Based the Tsai‐Hill criterion, the assembly interference t is the constraint condition which is the factor to meet the stress of design requirements. Then, the mathematical model of the flywheel is established by the objective function and the restriction with the particle swarm optimization algorithm (PSO). Finally, a specific CFRP/Al hybrid co‐cured flywheel is presented for the structural optimization with PSO by improving the energy storage density. In addition, the optimized flywheel is carried out to examine the static and dynamic requirements by the finite element method. The results indicate the PSO can be effectively used to optimize the structure of the CFRP/Al hybrid co‐cured high‐speed flywheel.
A bibliography of the literature on process capability indices (PCIs): 2010–2021, Part II: Multivariate PCI‐ and functional PCI‐related papers, special applications, software packages, and omitted papers
Authors: Yum Bong‐Jin 
Published: January 2023

AbstractThis is the second part of the bibliography on process capability indices (PCIs) for the period 2010–2021, and includes multivariate and functional PCI‐related papers, special applications, software packages, and papers omitted in the author's previous bibliography.
Denica 2.0 and Tactical Management Information System (TMIS)
Authors: Van Thuyne Gilles , Uvin Tom , Petrevska Nechkoska Renata , Poels Geert 
Published: January 2023

AbstractMiddle managers are often operating in complex and fast-moving environments, resulting in having to deal with enormous challenges in a short span of time, maneuvering diverse and numerous “givens” and aiming to achieve specific goals. These challenges are very diverse and require support tailored to the needs and characteristics of middle management. Due to the lack of tailored tools, middle managers often use methods that were originally designed for strategic or operational management, which they then adapt as best as possible to fit their tactical management needs. We thus see middle managers as the prototype of managers that have tactical management responsibilities, even though tactical management issues are also faced by executive, operational, and project managers. In a fast-changing world, heavily impacted by globalization and digitization, adaptability is one of the most essential characteristics of a middle manager. However, because of the lack of methods and systems tailored specifically to the tactical management level, middle managers are often not sufficiently supported to be able to deal with numerous givens, unpredictability, and a dynamic, turbulent, and complex environment. Hence, they lack proper support for being adaptable.
Risk factors for incomplete resection with pharyngeal endoscopic submucosal dissection and long-term prognosis after resection
Authors: Sakaguchi Yoshiki , Saito Yuki , Ando Mizuo , Yoshida Masafumi , Fukuoka Osamu , Kobayashi Kenya , Kubota Dai , Ohki Daisuke , Mizutani Hiroya , Niimi Keiko , Tsuji Yosuke , Fujishiro Mitsuhiro , Yamasoba Tatsuya 
Published: January 2023

Abstract
Background
Advances in endoscopic imaging technology have led to an increase in detection of superficial pharyngeal squamous carcinoma. Endoscopic submucosal dissection (ESD) has been reported to be effective for the treatment of these lesions, however there is still insufficient evidence on the long-term results of pharyngeal ESD.

Methods
This is a single-center retrospective study of all cases of superficial pharyngeal cancer that underwent ESD as primary treatment between January 2010 and May 2022. A total of 83 lesions in 63 patients were analyzed.

Results
The en bloc resection rate was 100%, and R0 resection rate was 59.0%, with an adverse event rate of 6.0%. During a mean observation period of 1134 days, there were 0 cases of disease-specific metastasis or death. However, the 5-year cumulative incidence of metachronous head and neck cancer after resection was 27.1% and the 5-year overall survival and 10-year overall survival after pharyngeal ESD were 87.0% and 69.6%, respectively. Of the 34 cases with non-R0 resection, local recurrence occurred in 8.8%. Location of lesion (p = 0.011), disparity between demarcation of the lesion with NBI and iodine staining (p = 0.026), and non-effective laryngeal elevation (p = 0.080) were risk factors for non-R0 resection.

Conclusion
Pharyngeal ESD is effective and safe. Further studies are needed to improve and standardize indications and strategies for pharyngeal ESD.
GTP energy dependence of endocytosis and autophagy in the aging brain and Alzheimer’s disease
Authors: Martínez Ricardo A. Santana , Pinky Priyanka D. , Harlan Benjamin A. , Brewer Gregory J. 
Published: January 2023

AbstractIncreased interest in the aging and Alzheimer’s disease (AD)-related impairments in autophagy in the brain raise important questions about regulation and treatment. Since many steps in endocytosis and autophagy depend on GTPases, new measures of cellular GTP levels are needed to evaluate energy regulation in aging and AD. The recent development of ratiometric GTP sensors (GEVALS) and findings that GTP levels are not homogenous inside cells raise new issues of regulation of GTPases by the local availability of GTP. In this review, we highlight the metabolism of GTP in relation to the Rab GTPases involved in formation of early endosomes, late endosomes, and lysosomal transport to execute the autophagic degradation of damaged cargo. Specific GTPases control macroautophagy (mitophagy), microautophagy, and chaperone-mediated autophagy (CMA). By inference, local GTP levels would control autophagy, if not in excess. Additional levels of control are imposed by the redox state of the cell, including thioredoxin involvement. Throughout this review, we emphasize the age-related changes that could contribute to deficits in GTP and AD. We conclude with prospects for boosting GTP levels and reversing age-related oxidative redox shift to restore autophagy. Therefore, GTP levels could regulate the numerous GTPases involved in endocytosis, autophagy, and vesicular trafficking. In aging, metabolic adaptation to a sedentary lifestyle could impair mitochondrial function generating less GTP and redox energy for healthy management of amyloid and tau proteostasis, synaptic function, and inflammation.
Process analyses of friction drilling using the Smoothed Particle Galerkin method
Authors: Stockburger Eugen , Zhang Wanmu , Wester Hendrik , Rosenbusch Daniel , Behrens Bernd-Arno 
Published: January 2023

AbstractAs a cost-effective hole production technique, friction drilling is widely used in industrial and automotive manufacturing. Compared with the traditional bolted connection, it enables the fastening of thin metal sheets and thin-walled tubular profiles. Friction drilling results in higher thread length and joint strength, thus better fulfilling the demand for lightweight structures. However, in the numerical simulation of friction drilling, the traditional finite element method encounters difficulties caused by the extreme deformation and complex failure of the material. A large number of elements are usually deleted due to the failure criterion, which significantly reduces the solution accuracy. The development of meshless methods over the past 20 years has alleviated this problem. Especially the Smoothed Particle Galerkin (SPG) method proposed in recent years and incorporating a bond-based failure mechanism has been shown to be advantageous in material separation simulations. It does not require element removal and can continuously evolve each particle's information such as strain and stress after the material failure. Therefore, the SPG method was used in this research for the simulation of frictional drilling of HX220 sheet metal. First the particle distance and the friction coefficient were varied to investigate the applicability of the SPG method to the friction drilling process. Predicted and experimental results were compared and found to be in high agreement. Furthermore, the influence of input parameters, such as sheet thickness, feed rate and rotational speed, on axial force as well as torque of the tool and the surface temperature of the workpiece during friction drilling was investigated numerically.
Interaction of Factors Determining Critical Power
Authors: Goulding Richie P. , Marwood Simon 
Published: January 2023

AbstractThe physiological determinants of high-intensity exercise tolerance are important for both elite human performance and morbidity, mortality and disease in clinical settings. The asymptote of the hyperbolic relation between external power and time to task failure, critical power, represents the threshold intensity above which systemic and intramuscular metabolic homeostasis can no longer be maintained. After ~ 60 years of research into the phenomenon of critical power, a clear understanding of its physiological determinants has emerged. The purpose of the present review is to critically examine this contemporary evidence in order to explain the physiological underpinnings of critical power. Evidence demonstrating that alterations in convective and diffusive oxygen delivery can impact upon critical power is first addressed. Subsequently, evidence is considered that shows that rates of muscle oxygen utilisation, inferred via the kinetics of pulmonary oxygen consumption, can influence critical power. The data reveal a clear picture that alterations in the rates of flux along every step of the oxygen transport and utilisation pathways influence critical power. It is also clear that critical power is influenced by motor unit recruitment patterns. On this basis, it is proposed that convective and diffusive oxygen delivery act in concert with muscle oxygen utilisation rates to determine the intracellular metabolic milieu and state of fatigue within the myocytes. This interacts with exercising muscle mass and motor unit recruitment patterns to ultimately determine critical power.
Academic Freedom as a Defensive Right
Authors: Stachowiak-Kudła Monika , Westa Sina , Santos Botelho Catarina , Bartha Ildikó 
Published: January 2023

AbstractEnsuring the proper implementation of academic freedom can be difficult both for policymakers and university authorities. Hence, great emphasis should be given to the defensive function of academic freedom. In this paper, we analyse the legal regulations and the jurisprudence of the constitutional courts of Germany, Hungary, Poland, Portugal, and Spain. We identify who is the holder of academic freedom, how the defensive function of academic freedom works and what academic activities are being protected. The study shows that individual countries emphasise slightly different aspects of the defensive function of academic freedom but remain unanimous on the essence of this function. As academic freedom is not defined unequivocally in most constitutions and legal frameworks, constitutional courts play a significant role in shaping its defensive function.
The Determinants of Non-compliance on Rabies Vaccination in North-West Peninsular Malaysia
Authors: Mohammad Basir Mohammad Fazrul , Mohd Hairon Suhaily , Tengku Ismail Tengku Alina , Che’ Muda Che Muzaini , Abdul Halim Hamizar Iqbal 
Published: January 2023

Abstract
Introduction
Rabies post-exposure vaccination (Rabies PEV) remains the most fundamental prevention of human Rabies if administered in a timely and appropriate manner. The study was aimed to determine the proportion and determinants of non-compliance on Rabies PEV among dog bite patients in Perlis, Malaysia from July 2015 to June 2020.

Methods
A retrospective cohort study was conducted using Perlis Rabid Potential Animal Bite Registry data. Independent variables and compliance status were obtained from the registry. Logistic regression analysis was utilized on 507 dog bite patients.

Results
Most of dog bite patients were age group of 46–60 years old (23.1%), male (61.3%), Chinese (49.5%), seeking treatment less than 24 h after the exposure (78.3%), category two of exposure (76.3%) and bitten on lower extremities (57.8%) by an owned dog (58.4%). Only 19.5% were non-compliance to Rabies PEV. Siamese had significantly two-timed (AOR: 2.00; 95% CI 1.06, 3.76) odd higher to become non-compliance. Being bitten during 3rd (AOR: 0.27; 95% CI 0.12, 0.59), 4th (AOR: 0.24; 95% CI 0.11, 0.52) and 5th (AOR: 0.20; 95% CI 0.09, 0.44) year of the outbreak had significantly lower odds to non-comply with Rabies PEV.

Conclusion
19.5% of dog bite patients still did not comply with the Rabies PEV series. Siamese would likely to non-comply whereas bitten on the 3rd, 4th and 5th years of outbreak less tendency to non-comply. Continuous health promotion to the public in the various languages despite outbreak status are ongoing to improve the perception of risk and benefit toward compliance of Rabies PEV.
Measuring clinical outcomes of highly multiplex molecular diagnostics for respiratory infections: A systematic review and conceptual framework
Authors: Timbrook Tristan T. , Wigmosta Tara B. , Hemmert Rachael B. , Dimas Jonathan B. , Krause Alexander , Spinali Sébastien , Thelen Meghan , Tongio Isabelle , Tissier Jean-Louis 
Published: January 2023

Abstract

Objectives:
To review methodologies and outcomes reporting among these studies and to develop a conceptual framework of outcomes to assist in guiding studies and production of clinical metrics.

Data sources:
PubMed and Embase from January 1, 2012, thru December 1, 2021.

Study eligibility criteria:
Studies evaluating highly multiplex molecular respiratory diagnostics and their impact on either clinical or economic outcomes.

Methods:
A systematic literature review (SLR) of methodologies and outcomes reporting was performed. A qualitative synthesis of identified SLRs and associated primary studies was conducted to develop conceptual framework for outcomes.

Results:
Ultimately, 4 systemic literature reviews and their 12 associated primary studies were selected for review. Most primary studies included patient outcomes focusing on antimicrobial exposure changes such as antibiotic (80%) and antiviral use (50%) or occupancy changes such as hospital length of stay (60%). Economic outcomes were infrequently reported, and societal outcomes, such as antibiotic resistance impact, were absent from the reviewed literature. Qualitative evidence synthesis of reported outcomes yielded a conceptual framework of outcomes to include operational, patient, economic, and societal domains.

Conclusions:
Our review highlights the significant heterogeneity in outcomes reporting among clinical impact studies for highly multiplex molecular respiratory diagnostics. Furthermore, we developed a conceptual framework of outcomes domains that may act as a guide to improve considerations in outcomes selection and reporting when evaluating clinical impact of these tests. These improvements may be important in synthesizing the evidence for informing clinical decision making, guidelines, and financial reimbursement.