bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mouse Tissue‐Resident Peritoneal Macrophages in Homeostasis, Repair, Infection, and Tumor Metastasis
Authors: Ardavín Carlos , Alvarez‐Ladrón Natalia , Ferriz Margarita , Gutiérrez‐González Alejandra , Vega‐Pérez Adrián 
Published: January 2023

AbstractLarge peritoneal macrophages (LPMs) are long‐lived, tissue‐resident macrophages, formed during embryonic life, developmentally and functionally confined to the peritoneal cavity. LPMs provide the first line of defense against life‐threatening pathologies of the peritoneal cavity, such as abdominal sepsis, peritoneal metastatic tumor growth, or peritoneal injuries caused by trauma, or abdominal surgery. Apart from their primary phagocytic function, reminiscent of primitive defense mechanisms sustained by coelomocytes in the coelomic cavity of invertebrates, LPMs fulfill an essential homeostatic function by achieving an efficient clearance of apoptotic, that is crucial for the maintenance of self‐tolerance. Research performed over the last few years, in mice, has unveiled the mechanisms by which LPMs fulfill a crucial role in repairing peritoneal injuries and controlling microbial and parasitic infections, reflecting that the GATA6‐driven LPM transcriptional program can be modulated by extracellular signals associated with pathological conditions. In contrast, recent experimental evidence supports that peritoneal tumors can subvert LPM metabolism and function, leading to the acquisition of a tumor‐promoting potential. The remarkable functional plasticity of LPMs can be nevertheless exploited to revert tumor‐induced LPM protumor potential, providing the basis for the development of novel immunotherapeutic approaches against peritoneal tumor metastasis based on macrophage reprogramming.
Extremely Sensitive Wearable Strain Sensor with Wide Range Based on a Simple Parallel Connection Architecture
Authors: Teng Fu‐Rui , Zi Tao‐Qing , Fang Jia‐Bin , Liu Chang , Wu Di , Li Ai‐Dong 
Published: January 2023

AbstractStrain sensors have attracted tremendous attention in healthcare monitoring and human–computer interaction due to their great potential in intelligent equipment. However, conventional strain sensors cannot possess high sensitivity, wide stretchable range, and low limit of detection (LoD) at the same time. Here, an ultrasensitive wearable strain sensor over a broad range based on the simple parallel connection architecture of Ir‐nanoparticles‐modified carbon nanotubes (Ir NPs@CNTs) and two Pt layers using a reticular patterned polymer substrate (Dragon Skin 30, (DS)) is reported. It exhibits an extremely high gauge factor of 13 590, broader strain range up to 98%, lower LoD of 0.02% strain, faster response time of 134 ms, and long‐term durability above 18 000 cycles. The mechanisms of performance improvement are proposed based on the synergistic and hierarchical effects of the combined sandwich structures by parallel connection on patterned DS, including geometric effect, crack formation/propagation in parallel grooves, and tunneling‐based charge carriers between IrNPs and IrNPs/CNTs. By introducing a metal nanolayer, the sensor also shows heat sensitivity at various environmental temperatures. The wearable sensors have been utilized for human‐motion detection with improved comprehensive performance, indicating their promising applications in flexible electronics and artificial intelligent fields.
Critical Assessment of the High Carrier Mobility of Bilayer In2O3/IGZO Transistors and the Underlying Mechanisms
Authors: Guo Min , Ou Hai , Xie Dongyu , Zhu Qiaoji , Wang Mengye , Liang Lingyan , Liu Fengjuan , Ning Ce , Cao Hongtao , Yuan Guangcai , Lu Xubing , Liu Chuan 
Published: January 2023

AbstractHigh‐performance bilayer In2O3/IGZO thin‐film transistors (TFTs) fabricated by pulsed laser deposition are reported. The TFTs exhibit an on/off current ratio of 109, a reversed subthreshold slope (ss) of 0.08 V dec−1, and a high saturation mobility of 47.9 cm2 V−1 s−1. The reliability of the mobility values is critically validated and assessed by four‐probe measurements, the transfer‐length method, and the temperature‐dependence. X‐ray photoelectron spectra are combined with C–V measurements to characterize the interface, and the results show that a two‐dimensional electron gas (2DEG)‐like state accumulates at the In2O3/IGZO interface. However, this state only forms in the subthreshold region and does not cause the high carrier mobility in the region above the threshold. Instead, the enhanced carrier mobility results from the intrinsic high mobility of the In2O3, the smooth surface, and the low‐defect states in the In2O3/IGZO bilayer with a good percolation transport path.
Optimizing selection of wheat genotypes through simulated individual BLUP and modified simulated individual BLUP
Authors: Machado e Silva Caique , Mezzomo Henrique Caletti , Alves Rodrigo Silva , de Resende Marcos Deon Vilela , Nardino Maicon 
Published: January 2023

AbstractThe early stages of wheat breeding programs often contain large number of plants in segregating populations that must be selected. Selecting the best populations and plants in those stages is not an easy task, making it necessary to use robust methodologies that facilitate the selection process. The goals of this work were to evaluate different methods for the selection of individual plants in early wheat breeding stages, compare the efficiency of each method, and suggest the most suitable one for implementation in wheat breeding programs. An experiment with 56 F2 segregant populations derived from a complete diallel, together with eight parents, was conducted and evaluated for grain yield (g pL−1). Analysis of variance and mixed model analysis were applied to obtain the genetic parameters and predict genotypic values. Four selection strategies were designed: mass selection and other three mixed model‐based methods (individual best linear unbiased prediction [BLUPI]; simulated individual best linear unbiased prediction [BLUPIS]; and modified simulated individual best linear unbiased [BLPISM]). The genotypic variability among and within populations allowed the selection of superior genotypes. Simple linear regression analysis and Spearman correlation analysis allowed to conclude that BLUPIS and BLUPISM are equivalent to BLUPI. The BLUPIS and BLUPISM should be used because they easily indicate for the selection of plants in populations with positive genetic effects, dismissing the evaluation of individual plants.
Youth engagement to achieve health equity: Are healthcare organizations and leaders prepared?
Authors: Augsberger Astraea , Young Adrienne , Toraif Noor , Morris Melanie , Barnett Katherine Gergen 
Published: January 2023

AbstractYouth engagement in institutional decision‐making is necessary to ensure policy and practice is responsive and relevant to youth and community needs. In particular, it is critical to engage the voices and experiences of youth of Color who have historically been marginalized by healthcare organizations. The present study used multiple methods to examine youth and adult perspectives on the facilitators and barriers to implementing a citywide youth advisory board of youths of Color for a safety net hospital. Data were analyzed using thematic analysis. The findings illustrate the need to employ an antiracist framework to ensure organizational and adult readiness to engage youth of Color in an advisory board. Organizational readiness included assessing organizational culture, clear expectation setting, and creating safe spaces for youth. Adult readiness included adult facilitators who are trained in antiracist and equity‐focused practice and the youth–adult partnership model, and a recognition of the bidirectional benefits of youth engagement in decision‐making. The implications and recommendations of this study are timely given the historical mistrust between healthcare organizations and communities of Color, as well as the racial health inequities that have been further exposed during the COVID‐19 pandemic.
Substantial Improvement of an Epimerase for the Synthesis of D‐Allulose by Biosensor‐Based High‐Throughput Microdroplet Screening
Authors: Li Chao , Gao Xin , Qi Hongbin , Zhang Wei , Li Lei , Wei Cancan , Wei Meijing , Sun Xiaoxuan , Wang Shusen , Wang Liyan , Ji Yingbin , Mao Shuhong , Zhu Zhangliang , Tanokura Masaru , Lu Fuping , Qin Hui‐Min 
Published: January 2023

AbstractBiosynthesis of D‐allulose has been achieved using ketose 3‐epimerases (KEases), but its application is limited by poor catalytic performance. In this study, we redesigned a genetically encoded biosensor based on a D‐allulose‐responsive transcriptional regulator for real‐time monitoring of D‐allulose. An ultrahigh‐throughput droplet‐based microfluidic screening platform was further constructed by coupling with this D‐allulose‐detecting biosensor for the directed evolution of the KEases. Structural analysis ofSinorhizobium frediiD‐allulose 3‐epimerase (SfDAE) revealed that a highly flexible helix/loop region exposes or occludes the catalytic center as an essential lid conformation regulating substrate recognition. We reprogrammed SfDAE using structure‐guided rational design and directed evolution, in which a mutant M3‐2 was identified with 17‐fold enhanced catalytic efficiency. Our research offers a paradigm for the design and optimization of a biosensor‐based microdroplet screening platform.
Greening of supply chain to drive performance through logical integration of supply chain resources
Authors: Sharma Mahak , Dhir Amandeep , AlKatheeri Haseena , Khan Mehmood , Ajmal Mian M. 
Published: January 2023

AbstractSustainability has always been a concern of humankind in one form or the other. Still, it has come into sharper focus after the promulgation of the sustainable development goals in 2015 and the disruptive forces unleashed by the COVID‐19 pandemic. Supply chain management is an aspect of business operations wherein the need for sustainability has been felt more keenly. The academic and business understanding of various nuances of incorporating sustainability, particularly environmental concerns in the supply chain, is still evolving. Our study seeks to enrich the growing literature in the area by proposing to uncover a novel, logical sequence of intangible supply chain resources that can amplify the impact of green supply chain management practices (GSCMPs) on business performance. We use the dual‐theoretical lens of a resource‐based view and stakeholder theories to conceptualize the sequential mediational role of supply chain visibility, resilience, and robustness between GSCMP and performance. Analyzing data collected from 318 individuals working in the manufacturing sector in the United Kingdom, we found a positive direct association of GSCMP with performance and the serial mediational role of visibility and robustness between the two. The findings of our study are pertinent for theorists as well as managers.
Qilong Capsule Alleviated MPTP‐Induced Neuronal Defects by Inhibiting Apoptosis, Regulating Autophagy in Zebrafish Embryo Model
Authors: Mo Cailian , Lin Shenghua , Li Zhen , Liu Xin , Ye Suyan , Liang Huiliang , Ma Honglin , Shen Chuanlin , Fan Wei , Wang Yuying , Liu Kechun , He Qiuxia 
Published: January 2023

AbstractQilong capsule (QLC) originates from the famous “Buyang Huanwu decoction” prescription. It is representative of drugs used in China during recovery from stroke, but its neuroprotective mechanism of action remains obscure. HPLC was used to evaluate the similarity of 10 batches of QLC samples. Then we used a zebrafish model to study the neuroprotective effect of QLC. At 24 hpf, embryos were treated with QLC and 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), and zebrafish were observed the neuronal length and the number of apoptotic cells in the brain at 72 hpf. At 120 hpf, we conduct zebrafish behavioural tests. We then also used qPCR to detect the expression of genes related to autophagy and apoptosis. The results showed that QLC significantly reduced the damage of dopaminergic neurons, the number of apoptotic cells in the brain, and alleviated motor disturbances induced by MPTP. We found that the mechanism of QLC activity involved decreased neuron cell death by inhibiting mitochondrial apoptosis and autophagy, promoting autophagy, degradation of alpha‐synuclein, and neuron cell growth, and rescuing the function of neurons damaged by MPTP. The results indicated that QLC protected against MPTP‐induced neuron injury and provided pharmacological evidence for clinical use of QLC.
Homogeneous Catalysis at its Edge: High‐Temperature Ru‐Catalysed Amination of Alcohols under Continuous Flow Conditions
Authors: Heider Christian , Winter Alina , Voß Viktoria , Vogt Dieter , Seidensticker Thomas 
Published: January 2023

AbstractCombining a tubular flow reactor with a robust homogeneous catalyst enabled running the alcohol amination at unique conditions, i. e., very high temperatures at low residence times. Catalytic activities were thus increased to unprecedented values of >900 h−1 in the synthesis of tertiary dimethylalkylamines directly from alcohols with excellent selectivities exceeding 99 %. Furthermore, several alcohols could be converted to the desired tertiary amines.
Widening the Landscape of Small Molecule Activation with Gold‐Aluminyl Complexes: A Systematic Study of E−H (E=O, N) Bonds, SO2 and N2O Activation
Authors: Sorbelli Diego , Belpassi Leonardo , Belanzoni Paola 
Published: January 2023

AbstractThe electronic features of gold‐aluminyl complexes have been thoroughly explored. Their similarity with Group 14 dimetallenes and other metal‐aluminyl complexes suggests that their reactivity with small molecules beyond carbon dioxide could be accessed. In this work, the reactivity of the [tBu3PAuAl(NON)] (NON=4,5‐bis(2,6 diisopropylanilido)‐2,7‐ditert‐butyl‐9,9‐dimethylxanthene) complex towards water, ammonia, sulfur dioxide and nitrous oxide is computationally explored. The reaction mechanisms computed for each substrate strongly suggest that all activation processes are in principle experimentally feasible. Electronic structure analysis highlights that, in all cases, the reactivity is driven by the presence of the poorly polarized electron‐sharing gold‐aluminyl bond, which induces a radical‐like reactivity of the complex towards all the substrates. A flat topology of the potential energy surface (PES) has been found for the reaction with N2O, where two almost isoenergetic transition states can be located along the same reaction coordinate with different geometries, suggesting that the N2O binding mode may not be a good indicator of the nature of N2O activation in a cooperative bimetallic reactivity. In addition, the catalytic potentialities of these complexes have been explored in the framework of nitrous oxide reduction. The study reveals that the [tBu3PAuAl(NON)] complex might be an efficient catalyst towards oxidation of phosphines (and boranes) via N2O reduction. These findings underline recurring trends in the novel chemistry of gold‐aluminyl complexes and call for experimental feedbacks.
Two new alkaloids from Dendrobium nobile Lindl. exhibited neuroprotective activity, and dendrobine alleviated Aβ1−42‐induced apoptosis by inhibiting CDK5 activation in PC12 cells
Authors: Zhang Cheng‐Chen , Kong Yan‐Li , Zhang Mao‐Sheng , Wu Qin , Shi Jing‐Shan 
Published: January 2023

AbstractDendrobium nobile Lindl. is registered in the Chinese Pharmacopoeia as a traditional medicine. Phytochemical investigation of the ethanol extract of D. nobile Lindl. stems yielded three alkaloid compounds, including two new compounds dendroxine B (2) and denrine B (3) as well as one known compound dendrobine (1). Here, we identified the structure of these compounds using spectroscopic analyses and compared them with those described in previous studies. Compounds 1–3 were found to show protective effect against amyloid‐β 1−42 (Aβ1−42)‐induced neurotoxicity in rat pheochromocytoma (PC12) cells, among which dendrobine exhibited the most significant neuroprotective effect. Hoechst 33342/propidium iodide staining indicated that dendrobine ameliorated Aβ1−42‐induced apoptosis. Moreover, quantitative real‐time polymerase chain reaction and western blot analysis analysis demonstrated that dendrobine suppressed the activation of cyclin‐dependent kinase 5 (CDK5), upregulated Bcl‐2 expression, and downregulated Bax, cyto‐c, and caspase‐3 expression. Molecular docking analysis and surface plasmon resonance assay suggested that dendrobine directly bound to CDK5 protein with a KD value of 2.05 × 10−4 M. In summary, alkaloids are the neuroprotective constituents of D. nobile Lindl., and dendrobine protected PC12 cells against Aβ1−42‐induced apoptosis by inhibiting CDK5 activation.
In the wind: Invasive species travel along predictable atmospheric pathways
Authors: Pretorius Ilze , Schou Wayne C. , Richardson Brian , Ross Shane D. , Withers Toni M. , Schmale David G. , Strand Tara M. 
Published: January 2023

AbstractInvasive species such as insects, pathogens, and weeds reaching new environments by traveling with the wind, represent unquantified and difficult‐to‐manage biosecurity threats to human, animal, and plant health in managed and natural ecosystems. Despite the importance of these invasion events, their complexity is reflected by the lack of tools to predict them. Here, we provide the first known evidence showing that the long‐distance aerial dispersal of invasive insects and wildfire smoke, a potential carrier of invasive species, is driven by atmospheric pathways known as Lagrangian coherent structures (LCS). An aerobiological modeling system combining LCS modeling with species biology and atmospheric survival has the potential to transform the understanding and prediction of atmospheric invasions. The proposed modeling system run in forecast or hindcast modes can inform high‐risk invasion events and invasion source locations, making it possible to locate them early, improving the chances of eradication success.
Effects of warming seasonal rotational grazing on plant communities' structure and diversity in desert steppe
Authors: Li Wen , Su Tingting , Shen Yan , Ma Hongbin , Zhou Yao , Lu Qi , Wang Guohui , Liu Zhuo , Li Jianping 
Published: January 2023

AbstractGrazing is the basic way of grassland utilization, and reasonable grazing is an important way to maintain the health of the grassland ecosystem. However, the traditional grazing time in warming seasons is negative for sustainable desert steppe ecosystem. Determining reasonable grassland grazing methods is to remain a critical issue for the ecological conservation and rational utilization of desert steppe. Therefore, our objectives were to explore the effects of warming seasonal rotation grazing on the species diversity and functional diversity of grassland plants and to reveal controlling factors of plant community diversity. The warm‐season rotational grazing modes included traditional time of grazing (FG), delayed start of grazing (YG), early end of grazing (TG), delayed start early end of grazing (YT), and enclosed steppe (CK). The results showed that the important value of Agropyron mongolicum of the gramineae and Lespedeza potaninii of the leguminosae in YG increased by 12.10%–120.66% and 23.57%–34.25% than other treatments (CK, FG, TG, and YT), respectively. Therefore, the YG treatment has more advantages on the IV of A. mongolicum of the gramineae and L. potaninii of the leguminosae. Warming seasonal rotational grazing (FG, YG, TG, and YT) significantly increased the important value of Leymus secalinus by 51.43%–79.64% compared with CK (p < .05). Compared with CK, FG and YG promoted the growth of gramineae and appropriately reduced the proportion of forbs. There was no significant difference in the Shannon–Wiener index between grazing treatments and CK, while the Shannon–Wiener index in YT increased by 21.43% and 15.71% compared with FG and YG (p < .05). The functional richness index in FG and YG significantly decreased by 19.05%–23.81% compared with CK and TG (p < .05). The results of the redundancy analysis showed that the diversity of plant communities was mainly affected by soil‐available nitrogen. These observations indicated that delayed start of grazing can improve the diversity of plant communities by increasing the important value of dominant plants in the community and promoting the growth of gramineous and leguminous plants, thereby optimizing the composition of community structure. Our findings can provide a theoretical basis for formulating a reasonable and scientific grazing period in desert steppe.
Coprophagy in moose: A first observation
Authors: Spitzer Robert , Åström Cecilia , Felton Annika , Eriksson Monica , Meisingset Erling L. , Solberg Erling J. , Rolandsen Christer M. 
Published: January 2023

AbstractCoprophagy, the eating of feces, has been documented in a wide range of species but appears to be rare or difficult to detect in deer (Cervidae). Here, we report the first observation of coprophagy in moose Alces alces, which was recorded using camera collars on free‐ranging moose in Norway. The footage shows an instance of allocoprophagy by an adult female moose in spring (May). We summarize the current knowledge about coprophagy in deer and briefly discuss potential drivers and possible implications for disease transmission. Further research is needed to determine whether coprophagy occurs frequently in moose and whether this behavior is positive (e.g., increased intake of nutrients) or negative (increased infection by parasites or pathogens).
Answers blowing in the wind: Detection of birds, mammals, and amphibians with airborne environmental DNA in a natural environment over a yearlong survey
Authors: Johnson Mark D. , Barnes Matthew A. , Garrett Nina R. , Clare Elizabeth L. 
Published: January 2023

AbstractAnalysis of environmental DNA (eDNA) from passively collected airborne dust has demonstrated broad success for sensitive and robust detection of plants. Recent experiments at small spatial scales have suggested that animals can also be detected using airborne eDNA. However, airborne eDNA analysis has never been used for a long‐term whole‐community assessment of a natural terrestrial community or with passive dust collectors. We conducted a metabarcoding survey targeting vertebrate eDNA from dust carried in the air on an approximately 130‐acre shortgrass prairie passively collected over the course of a year. Our survey detected a wide variety of animal forms including an amphibian species, several bird species, and both small and large mammals. We found that airborne eDNA signals changed with known patterns of animal activity, wind speed, and rainfall. Overall, we demonstrate that passively collected airborne dust carries eDNA from terrestrial animals and could be used to detect a wide variety of terrestrial vertebrate species in a natural environment with minimal effort. To develop this as a valuable monitoring tool, research needs to focus on the ecology of eDNA carried in the air, which includes the origin, state, transport, dispersal, and fate of eDNA in the environment.