bluuebunny/crossref_metadata_2025_split huggingface dataset:
An analytical representation of raindrop size distribution in a mixed convective and stratiform precipitating system as revealed by field observations
Authors: Okazaki Megumi , Oishi Satoru , Awata Yasuhiro , Yanase Tomoro , Takemi Tetsuya 
Published: March 2023

AbstractThis study investigated a rainfall event under a typhoon influence using a 2D video disdrometer and weather radar observations to characterize raindrop size distribution (DSD) in a mixed convective and stratiform precipitating system. During the time period when both convective and stratiform rainfalls existed, the DSDs generally indicated a monotonically decreasing shape with increasing particle size, with a relatively gradual decrease at intermediate particle size observed at certain times; this feature is attributed to the combined effect of convective and stratiform rainfalls. During the transitional period between convective and stratiform rainfalls, the DSDs exhibited a bimodal shape. The DSDs were well approximated by a newly proposed gamma raindrop distribution combined with exponential (GRACE) distribution function, which was defined as the sum of the exponential distribution and the gamma distribution. A comparison of the volume ratio of the exponential and gamma components of the GRACE distribution revealed that the exponential component of the DSD was larger than the gamma component in the bimodal DSD. These results suggest that the DSD became bimodal during the period when stratiform rainfall predominated because of the weakening of convective rainfall. The GRACE distribution is useful for understanding cloud‐microphysical processes in mixed stratiform and convective precipitation conditions.
X‐HESS: A large sample of highly accreting serendipitous AGN under the XMM‐Newton microscope
Authors: Laurenti M. , Tombesi F. , Vagnetti F. , Piconcelli E. , Guainazzi M. , Middei R. 
Published: March 2023

AbstractThe bulk of X‐ray spectroscopic studies of active galactic nuclei (AGN) are focused on local () sources with low‐to‐moderate (<0.3) Eddington ratio (). It is then mandatory to overcome this limitation and improve our understanding of highly accreting AGN. In this work, we present the preliminary results from the analysis of a sample of high‐ radio‐quiet AGN at , based on the 10th release of the XMM‐Newton serendipitous source catalog, that we named as XMM‐Newton High‐Eddington Serendipitous AGN Sample (X‐HESS). Almost of the X‐HESS AGN have multi‐epoch archival observations and of the sources can rely on simultaneous OM optical data. First results reveal sources showing signatures of ultra‐fast outflows and remarkable long‐ and short‐term X‐ray flux variations. Indeed in SDSS J095847.88+690532.7 (), one of the most densely monitored objects hosting a supermassive black hole, we discovered a variation of the soft X‐ray flux by a factor of >2 over approximately one week (rest‐frame). Large variations in the power‐law continuum photon index are also observed, questioning expectations from previously reported relations, for which would be a ubiquitous hallmark of AGN with .
Enhanced Zn2+ Transport in Ionic Liquid Electrolyte by Hydrofluoroether Dilution for High‐Power and Long‐Life Zn/Graphite Cells
Authors: Li Na , Wang Jia , Zhang Qingwei , Zhou Xinhong , Wang Hao , Lu Guoli , Zhao Jingwen , Chen Zheng , Cui Guanglei 
Published: March 2023

AbstractIonic liquid (IL) electrolytes have been widely used in high‐voltage Li‐based dual ion batteries (DIBs) due to their strong resistance against oxidation. However, their applications in Zn‐based DIBs are restricted because the high charge density of divalent Zn2+ aggravates the ionic interactions in ionic networks and leads to insufficient Zn2+ mobility. Herein, we introduce a hydrofluoroether diluent into a Zn‐based IL electrolyte to break down the larger ionic aggregates into smaller ones with weakened ionic interactions. This unique solvation structure reduces the Stokes radius of Zn2+ from 1.3 nm to 0.97 nm and increases its diffusion coefficient by ∼30 times while retaining the high oxidation stability, enabling the charge/discharge cycling of Zn/graphite DIBs at a high rate of 20 C. Moreover, the enhanced mobility of Zn2+ also promotes compact Zn deposition, which allows the operation of anode‐free Zn/graphite DIBs with 90 % capacity retention after 100 cycles.
The Arf family GTPases: Regulation of vesicle biogenesis and beyond
Authors: Li Fu‐Long , Guan Kun‐Liang 
Published: March 2023

AbstractThe Arf family proteins are best known for their roles in the vesicle biogenesis. However, they also play fundamental roles in a wide range of cellular regulation besides vesicular trafficking, such as modulation of lipid metabolic enzymes, cytoskeleton remodeling, ciliogenesis, lysosomal, and mitochondrial morphology and functions. Growing studies continue to expand the downstream effector landscape of Arf proteins, especially for the less‐studied members, revealing new biological functions, such as amino acid sensing. Experiments with cutting‐edge technologies and in vivo functional studies in the last decade help to provide a more comprehensive view of Arf family functions. In this review, we summarize the cellular functions that are regulated by at least two different Arf members with an emphasis on those beyond vesicle biogenesis.
Identifying the equifinal configurations of prompting green supply chain integration and subsequent performance outcome
Authors: Feng Taiwen , Sheng Hongyan 
Published: March 2023

AbstractAlthough green supply chain integration (GSCI) is essential for enterprises to address environmental challenges, existing literature mainly focuses on the net effect of a single factor that cannot well explain and guide the implementation of GSCI. Based on technology–organization–environment (TOE) framework, we develop a configurational framework and propose that GSCI depends on the interactions between perceived institutional force, green human resource management (GHRM), and big data analytics capability (BDAC). Moreover, we further investigate the impacts of high GSCI generated by different configurations on operational and environmental performance. By integrating fuzzy set qualitative comparative analysis (fsQCA) and propensity score matching, we reveal multiple equifinal configurations sufficient to three dimensions of GSCI and identify them into three types: GHRM oriented, GHRM + BDAC oriented, and perceived institutional force + GHRM + BDAC balance. The results further indicate that high GSCI triggered by multiple configurations has different effects on operational and environmental performance. These findings extend the GSCI research and provide theoretical guidance for managers to develop GSCI.
FIGHT‐102: A phase 1 study of pemigatinib in Japanese patients with advanced malignancies
Authors: Fujiwara Yutaka , Kuboki Yasutoshi , Furukawa Masayuki , Mizuno Nobumasa , Hara Hiroki , Ioka Tatsuya , Ueno Makoto , Takahashi Yasuo , Takahashi Shunji , Takeuchi Shinji , Lihou Christine , Ji Tao , Tian Chenwei , Shimizu Toshio 
Published: March 2023

AbstractBackgroundFIGHT‐102 was a phase 1, dose‐escalation, dose‐expansion study of pemigatinib in Japanese patients with advanced solid tumors. Here, we report safety, tolerability, and preliminary efficacy of pemigatinib from FIGHT‐102.MethodsPatients (≥20 years old) self‐administered oral pemigatinib 9, 13.5, or 18 mg QD on intermittent dosing (Part 1) or 13.5 mg QD intermittent or continuous dosing (Part 2). A dosing cycle was 21 days (2 weeks on/1 week off or 21 continuous days). Primary endpoint was safety. Secondary endpoints were pharmacokinetics, pharmacodynamics, and preliminary efficacy.ResultsForty‐four patients (Part 1, n = 14; Part 2, n = 30) were enrolled; most common tumors, cholangiocarcinoma, n = 8; esophageal, n = 6; 26 patients had confirmed FGF/FGFR alterations (Part 1, n = 3; Part 2, n = 23); 70.5% had ≥3 prior systemic therapies. Maximum tolerated dose was not identified. The recommended phase 2 dosage was determined to be 13.5 mg QD. Most common treatment‐emergent adverse events (TEAEs) were hyperphosphatemia (81.8%), dysgeusia (45.5%), stomatitis (43.2%), and alopecia (38.6%); most frequent Grade ≥3 TEAEs were anemia and decreased appetite (9.1% each). In Part 1, no patient achieved partial response (PR) or complete response, and 7 (50.0%) patients had stable disease (SD). In Part 2, 5 (16.7%) patients achieved PR (one each with cholangiocarcinoma, gall bladder cancer, breast cancer, urothelial tract/bladder cancer, and sweat gland carcinoma) and 6 (20%) had SD. Median duration of response was 9.56 months (95% CI: 4.17, 14.95).ConclusionsPemigatinib demonstrated manageable adverse events, consistent pharmacokinetics and pharmacodynamics profiles, and preliminary efficacy in Japanese patients with advanced solid tumors.
The baseline comorbidity burden affects survival in elderly patients with acute myeloid leukemia receiving hypomethylating agents: Results from a multicentric clinical study
Authors: Marconi Giovanni , Candoni Anna , Di Nicola Roberta , Sartor Chiara , Parisi Sarah , Abbenante Mariachiara , Nanni Jacopo , Cristiano Gianluca , Zannoni Letizia , Lazzarotto Davide , Giannini Benedetta , Baldazzi Carmen , Bandini Lorenza , Ottaviani Emanuela , Testoni Nicoletta , Bezzi Chiara Di Giovanni , Abd‐alatif Rania , Ciotti Giulia , Fanin Renato , Martinelli Giovanni , Paolini Stefania , Ricci Paolo , Cavo Michele , Papayannidis Cristina , Curti Antonio 
Published: March 2023

AbstractBackgroundIn older patients with acute myeloid leukemia (AML), the definition of fitness, prognosis, and risk of death represents an open question.MethodsIn the present study, we tested the impact on survival of disease‐ and patient‐related parameters in a large cohort of elderly AML patients homogeneously assigned to treatment with hypomethylating agents (HMAs).ResultsIn 131 patients with a median age of 76 years, we confirmed that early response (<0.001) and biology‐based risk classification (p = 0.003) can select patients with better‐predicted survival. However, a full disease‐oriented model had limitations in stratifying our patients, prompting us to investigate the impact of baseline comorbidities on overall survival basing on a comorbidity score. The albumin level (p = 0.001) and the presence of lung disease (p = 0.013) had a single‐variable impact on prognosis. The baseline comorbidity burden was a powerful predictor of patients' frailty, correlating with increased incidence of adverse events, especially infections, and predicted overall survival (p < 0.001).ConclusionThe comorbidity burden may contribute to impact prognosis in addition to disease biology. While the therapeutic armamentarium of elderly AML is improving, a comprehensive approach that combines AML biology with tailored interventions to patients' frailty is likely to fully exploit the anti‐leukemia potential of novel drugs.
A stable and adaptive polygenic signal detection method based on repeated sample splitting
Authors: Zhao Yanyan , Sun Lei 
Published: March 2023

AbstractFocusing on polygenic signal detection in high‐dimensional genetic association studies of complex traits, we develop a stable and adaptive test for generalized linear models to accommodate different alternatives. To facilitate valid post‐selection inference for high‐dimensional data, our study here adheres to the original sample‐splitting principle but does so repeatedly to increase stability of the inference. We show the asymptotic null distribution of the proposed test for both fixed and diverging numbers of variants. We also show the asymptotic properties of the proposed test under local alternatives, providing insights on why power gain attributed to variable selection and weighting can compensate for efficiency loss due to sample splitting. We support our analytical findings through extensive simulation studies and two applications. The proposed procedure is computationally efficient and has been implemented as the R package DoubleCauchy.
Mitigating hERG Liability of Toll‐Like Receptor 9 and 7 Antagonists through Structure‐Based Design
Authors: Das Nirmal , Bhattacharya Debomita , Bandopadhyay Purbita , Dastidar Uddipta Ghosh , Paul Barnali , Rahaman Oindrila , Hoque Israful , Patra Binita , Ganguly Dipyaman , Talukdar Arindam 
Published: March 2023

AbstracthERG is considered to be a primary anti‐target in the drug development process, as the K+ channel encoded by hERG plays an important role in cardiac re‐polarization. It is desirable to address the hERG safety liability during early‐stage development to avoid the expenses of validating leads that will eventually fail at a later stage. We have previously reported the development of highly potent quinazoline‐based TLR7 and TLR9 antagonists for possible application against autoimmune disease. Initial experimental hERG assessment showed that most of the lead TLR7 and TLR9 antagonists suffer from hERG liability rendering them ineffective for further development. The present study herein describes a coordinated strategy to integrate the understanding from structure‐based protein‐ligand interaction to develop non‐ hERG binders with IC50 >30 μM with retention of TLR7/9 antagonism through a single point change in the scaffold. This structure‐guided strategy can serve as a prototype for abolishing hERG liability during lead optimization.
Beta‐blocker use and mortality among patients with systolic heart failure and pacemaker rhythm
Authors: Perry Andrew S. , Maggioni Aldo P. , Tavazzi Luigi , Levy Wayne C. 
Published: March 2023

AbstractAimsBeta‐blockers are proven to improve survival among patients with heart failure with reduced ejection fraction. Their efficacy in patients with heart failure with reduced ejection fraction and pacemaker devices has not been demonstrated. Our aim was to test the hypothesis that beta‐blocker therapy is associated with improved survival in patients with chronic heart failure and a pacemaker rhythm on electrocardiogram (ECG).Methods and resultsThis is a post hoc analysis from the GISSI‐HF randomized clinical trial. We evaluated efficacy of beta‐blockers by creating Cox proportional hazards models adjusting for pacemaker rhythm and heart rate, among other variables. Interactions between pacemaker rhythm, heart rate, and beta‐blocker were also examined. Of the 6975 patients enrolled in the GISSI‐HF trial, 813 (11.7%) had a pacemaker rhythm on baseline ECG. Of these 813 patients, 511 (62.9%) were receiving beta‐blocker therapy. The effect of beta‐blocker therapy on mortality was assessed using multivariable Cox proportional hazards adjusted for 27 co‐variates. In the whole cohort, beta‐blocker therapy was significantly associated with reduced mortality (hazard ratio 0.79 [0.72–0.87], P < 0.001), without interaction between beta‐blockers, pacemaker rhythm and heart rate. Beta‐blocker therapy was beneficial in the sub‐group restricted to baseline pacemaker rhythm (hazard ratio 0.62 [0.49–0.79], P < 0.001).ConclusionsBeta‐blocker therapy is associated with improved survival among patients with heart failure and a pacemaker rhythm on ECG. Further studies are necessary to analyse differences between atrial and ventricular pacemakers.
Slow Magnetic Relaxation of Ni(III) Complexes toward Molecular Spin Qubits
Authors: Toshima Keiga , Sato Tetsu , Horii Yoji , Sato Kazunobu , Sugisaki Kenji , Breedlove B. K. , Takaishi Shinya , Li Zhao‐Yang , Yamashita Masahiro 
Published: March 2023

AbstractMolecule‐based magnetic materials are promising candidates for molecular spin qubits, which utilize spin relaxation behavior. Various kinds of transition metal complexes with S=1/2 have been reported to act as spin qubits with long spin‐spin relaxation times (T2). However, the spin qubit properties of low‐spin Ni(III) complexes are not as well known since Ni(III) compounds are often unstable. We report here the slow magnetic relaxation behavior and T2 values for three kinds of low‐spin Ni(III) based complexes with S=1/2 under magnetically diluted conditions. [Ni(cyclam)X2]Y (cyclam=1,4,8,11‐tetraazacyclotetradecane) with octahedral structures and [Ni(mnt)2]− (mnt=maleonitriledithiolate) with a square‐planar structure underwent slow magnetic relaxations in the presence of a dc magnetic bias field. From electron spin resonance (ESR) spectroscopy, the Ni(III) complexes exhibited observable T2, indicating that Ni(III) complexes are promising candidates for use as molecule‐based spin qubits.
Policy change to improve access to safe abortion care in federal Nepal
Authors: Lal Bibek Kumar , Pandav Rajesh Sambhajirao , Hyder Mohammad Khurshid Alam , Kalyanwala Shveta , Loi Ulrika Rehnström , Rajbhandari Sameena Vaidya , Singh Aliza , Kansal Amrita 
Published: March 2023

AbstractIn Nepal's constitution, safe abortion care is recognized as an essential component of a comprehensive approach to fulfill individuals' sexual and reproductive health and rights. In the current context of transition to a three‐level governance (federal, provincial, and local), there are opportunities to accelerate decentralization and devolution of decision‐making power, increase access to and coverage of safe abortion services, and improve health outcomes. This article documents the processes and results of the policy change undertaken by the Ministry of Health and Population in collaboration with development partners to decentralize the approval process of safe abortion sites and providers with the objective to increase access to and coverage of safe abortion services. With the decentralization of certification, the approval process for safe abortion service sites and providers has become simpler, less time consuming, and less expensive by reducing cost of traveling to Kathmandu or approaching authorities at the federal level. This has resulted in expanding safe abortion services across the country including remote areas with marginalized populations. Evidence‐based advocacy enabled policy change for decentralization of the approval process. Collaboration among stakeholders has been vital for implementing the policy change, including issuing directives from the federal to provincial levels and capacity strengthening of provincial level officials in understanding the requirements for approval of sites and providers.
Serious games for environmental education
Authors: Tan Cedric K. W. , Nurul‐Asna Hidayah 
Published: March 2023

AbstractSerious games are increasingly popular in multiple fields, including education and environmental engagement. We conducted a systematic review to examine the reasons for this increasing popularity, the features of successful serious games and the current trend of serious games application in environmental education. Our systematic search revealed 56 records of papers (from years 2009 to 2023) on the use of serious games for environmental education. Thirty‐five were published in the recent 5 years reflecting a growing interest in this area. The games were aimed at imparting knowledge (N = 28), changing attitude (N = 28) and changing behaviour (N = 19). Reasons for the increased application of serious games include the raising awareness on serious games and growing investment in serious games development and research, as well as better technological access through mobile devices. Successful serious games exhibit the following features: an immersive experience, meaningful engagement, a learn‐by‐doing involvement, simulation of real‐world environmental problems, autonomy in game decisions and the presence of a guiding host. This review also revealed two categories of digital serious games: computer games (N = 14) and mobile apps (N = 11), and three categories of physical games: board games (N = 6), card game (N = 1) and role‐playing games (N = 2). The gaps include (1) the lack of in‐game experience data that limits our understanding of the impacts of commercial games, (2) variation in game experience and conservation experience among participants and how this translates to the impacts of serious games, and (3) lack of understanding of how the effects of serious games with high complexities on adults learning. Serious games are increasingly being digitised and moving towards location‐based games, alternate reality, augmented reality and virtual reality. These games can facilitate interaction between learners and the natural environment, and in turn strengthen environmental awareness and appreciation.
Testing for multiple level shifts with an integrated or stationary noise component
Authors: Carrion‐i‐Silvestre Josep Lluís , Gadea María Dolores 
Published: March 2023

SummaryThe paper analyzes the detection and estimation of multiple level shifts regardless of the order of integration of the time series. We show that it is possible to extend the Bai‐Perron methodology (1998) to the I(1) and NI(1) nonstationary cases so that a unified framework to test for the presence of multiple level shifts in a robust way is designed. The finite sample performance of the proposed statistics is carried out, establishing a comparison with other existing approaches in the literature. The paper illustrates the implementation of the statistics focusing on the real exchange rate with time series that either cover a long time period or provide a worldwide analysis. Robust detection of multiple level shifts is of great importance to define the statistical approach that is used to test the purchasing power parity hypothesis.
Raman spectroscopy in chronic heart failure diagnosis based on human skin analysis
Authors: Khristoforova Yulia A. , Bratchenko Lyudmila A. , Skuratova Maria A. , Lebedeva Elena A. , Lebedev Petr A. , Bratchenko Ivan A. 
Published: March 2023

AbstractThis work aims at studying Raman spectroscopy in combination with chemometrics as an alternative fast noninvasive method to detect chronic heart failure (CHF) cases. Optical analysis is focused on the changes in the spectral features associated with the biochemical composition changes of skin tissues. A portable spectroscopy setup with the 785 nm excitation wavelength was used to record skin Raman features. In this in vivo study, 127 patients and 57 healthy volunteers were involved in measuring skin spectral features by Raman spectroscopy. The spectral data were analyzed with a projection on the latent structures and discriminant analysis. 202 skin spectra of patients with CHF and 90 skin spectra of healthy volunteers were classified with 0.888 ROC AUC for the 10‐fold cross validated algorithm. To identify CHF cases, the performance of the proposed classifier was verified by means of a new test set that is equal to 0.917 ROC AUC.
Photodissociation dynamics of acetaldehyde at 267 nm: A computational study of the CO‐forming channels
Authors: Yuan Yu‐Wen , Tsai Po‐Yu 
Published: March 2023

AbstractA recent experiment on the 267 nm photolysis of gaseous acetaldehyde reveals that the molecular products (CO + CH4) present product state distributions with computation –experiment discrepancy. This work aims to provide solution to such issue. The direct dynamics simulation of classical trajectories and the generalized multi‐center impulsive model (GMCIM) are both utilized to predict the product state distributions of CO and CH4 from 267 nm photolysis of acetaldehyde. Comparison with the experimental observation provides an assessment of the conventional approach of minimum energy path within the framework of three‐center transition state (TS) and CH3‐roaming pathways. The result shows that the high‐speed products observed in experiment are likely formed via the three‐center TS pathway. The reasons that lead to the discrepancy between computation and experiments in previous studies are also investigated. A better agreement between computational and state‐resolved experimental results can be achieved by selecting specific internal states of CO product from the computational data.