bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of feeding total mixed ration with ad libitum or restricted pelleted starter on growth performance, rumination behaviour, blood metabolites and rumen fermentation of Holstein calves
Authors: Spina Anna Antonella , Lopreiato Vincenzo , Britti Domenico , Minuti Andrea , Trevisi Erminio , Morittu Valeria Maria 
Published: September 2023

Abstract
The objective of this study was to evaluate the effects of diet with ad libitum TMR and restricted starter on animal performance, rumination time, blood metabolites and rumen fermentation of Holstein calves during the pre- and post-weaning periods. Thirty female Holstein calves were randomly assigned at birth (38.5 ± 1.96 kg) to receive 3 treatments. Calves, from 21 days of age, were fed 1 of 3 treatments as follows: Control diet (CTR) with TMR and starter ad libitum; Treatment 1 diet (TRT1) with TMR and starter ad libitum; Treatment 2 diet (TRT2) with ad libitum TMR and restricted amount of calf starter (50% of the intake recorder in the control group day by day. The results showed that the reduced amount of starter did not compromise the growth of calves nor did it compromise the ruminal and metabolic parameters of the animals. The inclusion of ad libitum TMR indeed, improved the rumination time especially after weaning. Overall, the results indicated that the calf starter can be partially replaced with a TMR in weaning calves, reducing the feeding costs of weaning dairy calves.
Rendering Lineament Induced Stream alignment in Upper Krishna Basin, India: A Geospatial Approach
Authors: Pardeshi Suchitra S. , Pardeshi Sudhakar , Autade Sumant Eknath , Raut Tushar Prakash 
Published: September 2023

Abstract
Lineaments play an important role in drainage development, stream alignment and groundwater recharge. These are traced as surface or subsurface features. A linear feature that is associated with dislocation and deformation is known as lineament. The present study aimed to identify the influence of lineaments extracted from satellite images in the Upper Krishna River basin in India. Remote sensing datasets are considered the best option when using image enhancement techniques for extracting lineaments. Lineament studies are useful for groundwater and mineral exploration and also in the field of engineering geology. The availability of high-resolution satellite data and image processing techniques have rendered it further convenient to map lineaments. In the present study, lineaments were extracted from Sentinel–2 images with a resolution of 10 m, using various image processing techniques. A total of 1314 lineaments were extracted from the study area with a total length of 3983.44 km. The analysis of the extracted lineaments revealed that the lineament density was higher in the upper reaches of the basin, where the undulating hilly region is located in the Western Ghats. This finding implied that these regions have a high structural deformation and a higher groundwater infiltration potential. Moreover, approximately 15% of the total stream length was observed to be influenced by the lineaments. The maximum influence of lineaments was observed in the source region. The lineament extraction results of the present study would assist in understanding the geomorphology of this region and the structural control on the streams and groundwater potential zones, particularly as a contribution to water resource management in this region.
Real-World Outcomes Of Lu-177 PSMA In Patients With Metastatic Castration-Resistant Prostate Cancer: A Retrospective Single-Center Experience
Authors: Karci Ebru , Aydin Sabin Goktas , Bilici Ahmet , Atasever Tamer , Cakir Tansel , Olmez Omer Fatih , Acikgoz Ozgur , Kutlu Yasin , Yildiz Ozcan 
Published: September 2023

Abstract
Aim: This studyaimed to assess the influence of laboratory and clinicopathological features on survival and treatment response as well as the importance of uptake changes in PSMA-PET-CT after Lutetium-177-PSMA treatment in metastatic castration-resistant prostate cancer(mCRPC).
Material-Method: Totally,38 men with mCRPC who received Lu-177 )at a dose of 4.0 to 6.8 GBq with a mean of 5.5 GBq once every six or nine weeks for 1 to 6 cycles (median 3) were included in this study. PSMA PET with computed tomography was performed for response evaluation. Pre and post-treatment laboratory and imaging findings were obtained from patients’ charts and analyzed retrospectively.
Results: At a median follow-up of 12.2 months, the median PFS and OS were 5.8 and 12.3 months, respectively. The objective response rate was 36.8%. Any grade and grade3/4 toxicity rates were as follows:86.8%(n=33) and57.9%(n=22).The presence of visceral metastasis, ALP, PSA, and SUVmax values were significant prognostic factors for PFS.The SUVmax value of <4 after treatment was an independent significant factor for PFS in multivariate analysis (p=0.002; HR:6.6,95%CI 2.03-22.00). The significant prognostic factors for OS were previous treatment lines, presence of visceral metastasis, ECOG PS PSA and ALP values, and median SUV max value after treatment.The multivariate analysis for OS indicated that ECOG PS (p=0.01, HR:16.7, 95%CI 1.58-176.32), pre LU-177-PSMA ALP values (p=0.05;HR:0.96,95% CI 0.93-1.00),post Lu-177 PSA values(p=0.02;HR:1.01,95%CI1.00-1.03)and SUV max value p=(0.005;HR:6.6,95%CI1.74-25.1)were independent prognostic factors.
Conclusion: ECOG PS, baseline ALP values, PSA response, and SUV response of the target lesion were the independent prognostic factors for OS. Thus Lu-177-PSMA is an effective option with a good safety profile in second and later lines of treatment for patients with mCRPC.
Core-shell structured SiO2@C-Sn/SnO2 nanosphere as an anode material for high-performance lithium-ion batteries
Authors: Zhai Jianguang , HUANG YUCHEN , wei Yongji 
Published: September 2023

Abstract
In this paper, a SiO2@C-Sn/SnO2 nanospheres with core-shell structure were synthesized by the hard template method using resorcinol-formaldehyde resin as a carbon source and the hydrolysis of SnCl4-5H2O. Tin material as lithium battery anode has the advantages of high specific capacity and low voltage plateau. This innovative core-shell structure exhibits excellent electrochemical lithium storage performance, making it an excellent candidate for lithium-ion batteries. After 100 cycles, the material demonstrated a notable reversible capacity of 591.8 mAh g− 1 at a current density of 100 mA g− 1. In addition, the stability of the core-shell structure provides excellent capacity retention for the battery.
Numerical modelling of the upwelling and associated hydrodynamics at various scales along the coral reefs at Sodwana Bay, South Africa
Authors: Wells Calvin , Pringle Justin , Stretch Derek 
Published: September 2023

Abstract
Coral reefs are strongly influenced by hydrodynamics and physical processes on various length and time scales, and understanding coral reef systems are crucial for the maintenance and survival of the reefs. Coral reefs around the world are under increasing threat to global climate change, and coral bleaching is a major concern for the health and survival of these reefs. Certain coral reefs are situated in high latitude areas where the complex ocean flow patterns interact with topographical features, providing certain refuges to rising ocean temperatures. A prominent example is the Sodwana Bay coral reef system which has shown resilience to coral bleaching. This resilience has been attributed to cold water temperature anomalies that cause short-term temperature fluctuations on the reefs. This study explores hydrodynamics at various scales around the Sodwana Bay coral reefs and associated short-term temperature anomalies. A flexible mesh hydrodynamic model of the southwest region of the Indian Ocean was developed to investigate short-term temperature anomalies on the Sodwana coral reef system located along the northeastern coast of South Africa. The model successfully replicates the observed temperature anomalies over a chosen representative year. The modelled on-reef temperatures during the temperature anomaly events were also compared to temperatures near Sodwana from the reanalysis NEMO global ocean model. The higher model resolution around Sodwana results in less numerical effects and smoothing of the temperature fields in the nearshore region when compared to the reanalysed NEMO model. A representative anomaly in Febru-ary 2004 was also investigated using the nested model to delineate the impact of local hydrodynamics in and around submarine canyons on the representative temperature anomaly.
Lateral root enriched Massilia associated with plant flowering in maize
Authors: Wang Danning , He Xiaoming , Baer Marcel , Lami Klea , Yu Baogang , Tassinari Alberto , Salvi Silvio , Schaaf Gabriel , Hochholdinger Frank , Yu Peng 
Published: September 2023

Abstract
Background
Beneficial interactions between plants and soil microorganisms are critical for crop fitness and resilience. However, it remains obscure how microorganisms are assembled across different root compartments and to what extent such recruited microbiomes determine crop performance. Here, we surveyed the root transcriptome and the root and rhizosphere microbiome via RNA sequencing and full-length (V1−V9) 16S rRNA gene sequencing from genetically distinct monogenic root mutants of maize (Zea mays L.) under different nutrient-limiting conditions.
Results
Integrated transcriptomic and microbial analyses demonstrated that mutations affecting lateral root development had the largest effect on host gene expression and microbiome assembly, as compared to mutations affecting other root types. Cooccurrence and trans-kingdom network interactions analysis demonstrated that the keystone bacterial taxon Massilia (Oxalobacteraceae) is associated with root functional genes involved in flowering time and overall plant biomass. We further observed that the developmental stage drives the differentiation of the rhizosphere microbial assembly, especially the interactions of the keystone bacteria Massilia with functional genes in reproduction. Taking advantage of microbial inoculation experiments using a maize early flowering mutant, we confirmed that Massilia-driven maize growth promotion indeed depends on flowering time.
Conclusion
We conclude that specific microbiota supporting lateral root formation could enhance crop performance by mediating functional gene expression underlying plant flowering time in maize.
Preliminary study: Cognitive behavioural therapy for insomnia in adolescents suffering from anorexia nervosa
Authors: CREVITS Léna , BAT-PITAULT Flora , SILVA Catarina GONZALEZ DA 
Published: September 2023

Abstract
Purpose: Insomnia and anorexia nervosa (AN) are frequently comorbid, which negatively impacts the evolution and the prognosis of AN. Thus, the management of sleep disorders appears to be essential. The aim of this retrospective study is to asses, for the first time, the efficacy of the cognitive and behavioural therapy for insomnia (CBT-I) on sleep disturbances in adolescents with AN. To do so, we investigated the impact of the CBT-I on BMI, anorexia nervosa symptoms, anxiety and depressive symptoms, emotionality and quality of life. These features were compared between two groups of patients with AN, one following the CBT-I, and the other receiving the regular treatment at the psychiatric unit.
Methods: Data were collected between January and May 2022. 42 adolescents in treatment at the Eating Disorders care specialised unit at Salvator Hospital in Marseille were included. They were randomly assigned to the CBT-I or the control group. Diverse clinical elements were assessed using sleep diaries and validated subjective measurement scales.
Results: Present findings show a significant improvement in certain sleep parameters: sleep latency, total wake time, and sleep efficacy ; as well as physical well-being, favouring the group undergoing the CBT-I.
Conclusion: This preliminary study on sleep disturbances in adolescents with AN provides support to the efficacy of CBT-I, with significant improvements in several sleep parameters, as well as in physical well-being. These promising initial results, underline the relevance on this topic and its potential benefits for a more suitable treatment for adolescents suffering from AN.
Level of evidence: Level V, restrospective study
Neuroinflammation in a Mouse Model of Alzheimer’s Disease versus Auditory Dysfunction: Machine Learning Interpretation and Analysis
Authors: Na Daxiang , Yang Yidan , Xie Li , Piekna-Przybylska Dorota , Bunn Dominic , Shamambo Maleelo , White Patricia 
Published: September 2023

Abstract
Background
Auditory dysfunction, including central auditory hyperactivity, hearing loss and hearing in noise deficits, has been reported in 5xFAD Alzheimer’s disease (AD) mice, suggesting a causal relationship between amyloidosis and auditory dysfunction. Central auditory hyperactivity correlated in time with small amounts of plaque deposition in the inferior colliculus and medial geniculate body, which are the auditory midbrain and thalamus, respectively. Neuroinflammation has been associated with excitation to inhibition imbalance in the central nervous system, and therefore has been proposed as a link between central auditory hyperactivity and AD in our previous report. However, neuroinflammation in the auditory pathway has not been investigated in mouse amyloidosis models.
Methods
Machine learning was used to classify the previously obtained auditory brainstem responses (ABRs) from 5xFAD mice and their wild type (WT) littermates. Neuroinflammation was assessed in six auditory-related regions of the cortex, thalamus, and brainstem. Cochlear pathology was assessed in cryosection and whole mount. Behavioral changes were assessed with fear conditioning, open field testing and novel objection recognition.
Results
Reliable machine learning classification of 5xFAD and WT littermate ABRs were achieved for 6M and 12M, but not 3M. The top features for accurate classification at 6 months of age were characteristics of Waves IV and V. Microglial and astrocytic activation were pronounced in 5xFAD inferior colliculus and medial geniculate body at 6 months, two neural centers that are thought to contribute to these waves. Lower regions of the brainstem were unaffected, and cortical auditory centers also displayed inflammation beginning at 6 months. No losses were seen in numbers of spiral ganglion neurons (SGNs), auditory synapses, or efferent synapses in the cochlea. 5xFAD mice had reduced responses to tones in fear conditioning compared to WT littermates beginning at 6 months.
Conclusions
Serial use of ABR in early AD patients represents a promising approach for early and inexpensive detection of neuroinflammation in higher auditory brainstem processing centers. As changes in auditory processing are strongly linked to AD progression, central auditory hyperactivity may serve as a biomarker for AD progression and/or stratify AD patients into distinct populations.
Child and Adolescent Psychiatry and Mental Health Transitioning to Adult Mental Health Services for young people with ADHD: an Italian-based Survey on practices for Pediatric and Adult Services
Authors: Roberti Elisa , Scarpellini Francesca , Campi Rita , Giardino Michele , Clavenna Antonio , Bonati Maurizio 
Published: September 2023

Abstract
Background. Supporting young ADHD patients in transition to adult services is essential. Yet, the low percentages of successful referrals and the issues reported by patients and clinicians stress the need for further attention to transitioning practices. The present study assessed the transitioning process of Attention-Deficit/Hyperactivity Disorder (ADHD) patients in Child and Adolescent Mental Health Services (CAMHS) and Adult Mental Health Services (AMHS) in the Italian territory. We asked child and adult psychiatrists to report the current state of services and their observations on limitations and possible future matters that must be addressed. Method. Seventy-seven centers (42 CAMHS, 35 AMHS) filled in a web-based survey in which they reported the number of ADHD patients, how many transitioning patients they had within the past year, and how they structured transition. Results. A fragmented picture emerged from the survey. Lack of resources, training, and communication between services hinder the transition process, and many adult patients remain under CAMHS' care. While some services have a protocol, there is no structured guidance that can help improve integration and continuity of treatment. Conclusion. The observed situation reflects a need for improvement and standard guidelines to enable a successful transition process, considering clinicians' and patients' necessities.
Is Strategy Instruction Still Needed? A Comprehensive Analysis of Learner Strategies in High School EFL Context
Authors: Çelik Ferdi , Yeşilel Deren Başak Akman 
Published: September 2023

Abstract
This quantitative paper thoroughly explores strategy utilization among English as a Foreign Language (EFL) students in a Turkish high school, examining potential differences based on proficiency levels and gender. A sample of 78 students (39 females, 39 males) participated, and data collection involved a comprehensive strategy inventory. The findings revealed that high-proficiency learners exhibited a wider range of strategies, with compensation and metacognitive strategies being the most prominent. Medium proficiency learners demonstrated moderate strategy use, emphasizing balance and metacognitive strategies. Conversely, low-proficiency learners engaged in strategies to a lesser extent, leaning towards social strategies. Gender, however, did not significantly influence overall strategy use across proficiency levels. Practical implications are discussed, suggesting EFL teachers incorporate metacognitive and cognitive strategy instruction to optimize students’ learning. Coursebook authors are recommended to integrate strategy use, particularly tailored for lower proficiency learners, while learners are encouraged to adopt strategies consciously to enhance their language learning experience. This research contributes valuable insights into language learning strategies, facilitating improved educational practices for EFL students.
Patterns of Corruption During COVID-19 in Bangladesh
Authors: Sakib Nurul Huda , Mollik Md Meshkat 
Published: September 2023

Abstract
Corruption during COVID-19 has reached global proportions. During COVID-19, corruption was rampant in numerous nations around the world, especially in the health sector. Bangladesh is not an exception. This paper aims to analyse the various forms and faces of corruption with their frequency levels using AntConc and corpus linguistics analysis, as well as convert all of the data into visual graphics using SPSS and R-Programming. Using related keywords, over 1200 corruption news stories were gathered from a number of national daily newspapers and national television news sources. The analysis begins with COVID-19 by reviewing categorical forms of political corruption and bureaucratic corruption, demonstrating the most essential examples of typologies, establishing corruption levels, and indicating where corruption originated. All analyses in this study, including occurrences, keywords, n-grammes, and concordances, indicate that corruption during COVID-19 was substantial and had a substantial effect on the health sector. Therefore, we begin by identifying corruption month-by-month in both 2020 and 2021. Moreover, we discovered political, bureaucratic, and both types of corruption concurrently during the time period in which all stakeholders benefited from the corrupt transition. Along with bribery and extortion, we found that nepotism, embezzlement, and lobbying were prevalent during the time period. We also discovered statistically significant instances of terms such as 'health,' 'government,' 'corruption, “money/tk,' and 'JKG', which indicate institutional corruption. In addition, while analysing the evidence of corruption frequency in Bangladesh, we discovered that it was symmetrical and unimodal. The average frequency of corruption during COVID-19 in Bangladesh was approximately 70, with a standard deviation of 20. In conclusion, our qualitative analysis identifies three major problems: corruption in the "health" sector, the greed of involved stakeholders, and the incompetence of government officials, which has made governance in Bangladesh more challenging.
A self-amplifying loop of TP53INP1 and P53 drives oxidative stress-induced apoptosis of bone marrow mesenchymal stem cells
Authors: Zhang Fei , li fanchao , Wang Tao , Peng Wuxun , Xie Zhihong , Luo Hong , Dong Wentao , Zhang Jian , Ren Chao 
Published: September 2023

Abstract
Bone marrow mesenchymal stem cell (BMSC) transplantation is a promising regenerative therapy, but the survival rate of BMSCs after transplantation is low. Oxidative stress is one of the main reasons for the high apoptosis rate of BMSCs after transplantation, so there is an urgent need to explore the mechanism of oxidative stress-induced apoptosis of BMSCs. Our previous transcriptome sequencing results suggested that the expression of P53-induced nuclear protein 1 (TP53INP1) and the tumor suppressor P53 (P53) was significantly upregulated during the process of oxidative stress-induced apoptosis of BMSCs. The present study further revealed the role and mechanism of TP53INP1 and P53 in oxidative stress-induced apoptosis in BMSCs. Overexpression of TP53INP1 induced apoptosis of BMSCs, knockdown of TP53INP1 alleviated oxidative stress apoptosis of BMSCs. Under oxidative stress conditions, P53 is regulated by TP53INP1, while P53 can positively regulate the expression of TP53INP1, so the two form a positive feedback loop. To clarify the mechanism of feedback loop formation, We found that TP53INP1 inhibited the ubiquitination and degradation of P53 by increasing the phosphorylation level of P53, leading to the accumulation of P53 protein. P53 can act on the promoter of the TP53INP1 gene and increase the expression of TP53INP1 through transcriptional activation.This is the first report on a positive feedback loop formed by TP53INP1 and P53 under oxidative stress. The present study clarified the formation mechanism of the positive feedback loop. The TP53INP1–P53 positive feedback loop may serve as a potential target for inhibiting oxidative stress-induced apoptosis in BMSCs.
Comparision Between CO2 Laser Tonsillectomy and Cold Dissection Tonsillectomy: Single Blind Randomised Controlled Study
Authors: Sanjel Anup 
Published: September 2023

Abstract
Background: History of tonsillectomy is very long back and the first procedure was carried out by Celsus in 40 AD. There are many methods of tonsillectomy like guillotine, cold steel, snare with suture, electro cautery, hot-knife, bipolar, LASER etc.
Aims and Objectives: The aim of this study was to compare intensity of post-operative pain between CO2 laser tonsillectomy and cold dissection tonsillectomy.
Methods: Single blind Randomized controlled study was conducted at BPKIHS, Department of Otorhinolaryngology and Head & Neck surgery
Results: Study revealed less postoperative pain in LASER side than in cold steel dissection side. Average pain score scaled with VAS was 7.40±1.297 in cold steel dissection whereas 5.15±1.292 for CO2 LASER tonsillectomy. The pain score at 24hrs shows that more than half of the patient with cold steel dissection side have developed severe degree of pain. Whereas most of the patient have only moderate level of pain in the CO2 laser tonsillectomy side. Pain score was 3.65±1.231 for CO2 LASER tonsillectomy and 6.45±1.319 in a cold dissection side at 48hrs. The mean pain score of LASER tonsillectomy at 72 hours was 2.88±0.82 whereas the mean pain score of cold steel dissection method was 4.63±1.079.
Conclusion: In the present study, The CO2 laser is associated with less post-operative pain than cold steel dissection method however duration of surgery is more on the LASER side.