bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reading intervention for students with intellectual disabilities without functional speech who require augmentative and alternative communication: a multiple single-case design with four randomized baselines
Authors: Ulriksen Line Britt , Bilet-Mossige Marthe , Moreira Hugo Cogo , Larsen Kenneth , Nordahl-Hansen Anders 
Published: June 2023

Abstract
Background
Literacy is one of the most important skills a students can achieve, as it provides access to information and communication. Unfortunately, literacy skills are not easily acquired, especially for students with intellectual disabilities who require augmentative and alternative communication (AAC). There are many barriers to literacy acquisition, some due to low expectations from parents and teachers and lack of evidence-based reading programs and reading materials adapted for AAC. Barriers as a result of extensive support needs is also a real factor. This trial aims to deliver reading instructions to 40 students with intellectual disabilities who require AAC and contribute in the debate on how to best support this population through reading instructions to maximizes their reading skills.

Methodology
Forty non-verbal or minimally verbal students (age 6–14) with intellectual disabilities who require AAC will be part of a reading intervention with a multiple single-case design with four randomized baselines. The intervention period will last for 18 months and will commence in March 2023. The students will receive the intervention in a one-to-one format, working systematically with a reading material that contains phonological awareness and decoding tasks based on the Accessible Literacy Learning (ALL) developed by Janice Light and David McNaughton. All the teachers will be trained to deliver the reading intervention.

Discussion
The reading material “Lesing for alle” (Reading for all) is based on and follow the strategies behind the research of ALL. The current trial will through a reading intervention contribute to move beyond only teaching sight words and combine several reading components such as sound blending, letter-sound correspondence, phoneme segmentation, shared reading, recognition of sight words, and decoding. The strategies and methods in use is built on the existing science of reading, especially what has been effective in teaching reading for students with intellectual disabilities who require AAC. There is limited generalizability of prior findings in reading-related phonological processing interventions to different populations of them who use AAC specially outside of the USA. More research is needed to understand how programs designed to improve reading skills across other settings understand the program’s long-term effects and to study the effectiveness when delivered by educators who are not speech language therapists or researchers.

Trial registration
NCT05709405. Registered 23 January 2023.
Quantification of hematopoietic stem and progenitor cells by targeted DNA methylation analysis
Authors: Bocova Ledio , Hubens Wouter , Engel Cordula , Koschmieder Steffen , Jost Edgar , Wagner Wolfgang 
Published: June 2023

AbstractHematopoietic stem and progenitor cells (HSPCs) are quantified in daily clinical practice by flow cytometry. In this study, we provide proof of concept that HSPCs can also be estimated by targeted DNA methylation (DNAm) analysis. The DNAm levels at three individual CG dinucleotides (CpG sites) in the genes MYO1D, STK17A, and SP140 correlated with CD34+ cell numbers in mobilized peripheral blood and with blast counts in leukemia. In the future, such epigenetic biomarkers can support the evaluation of stem cell mobilization, HSPC harvesting, or blast count in leukemia.
Plasma activated Ezhangfeng Cuji as innovative antifungal agent and its inactivation mechanism
Authors: Lin Lin , Zhuo Yue , Dong Qiran , Yang Chunjun , Cheng Cheng , Liu Taofeng 
Published: June 2023

AbstractCandida albicans is a highly drug-resistant fungus for which new treatments are urgently needed due to the lack of clinically effective options. In this study, we evaluated the antifungal activity and mechanism of plasma-activated Ezhangfeng Cuji (PAEC) against Candida albicans and compared it with physiological saline (PS), plasma-activated physiological saline (PAPS) and Ezhangfeng Cuji (EC). After dielectric barrier discharge (DBD) plasma treatment with EC for 20 min followed by a 10 min immersion of Candida albicans, the fungus was reduced by approximately 3 orders of magnitude. High performance liquid chromatography (HPLC) results showed an increase of 41.18% and 129.88% in the concentration of oxymatrine and rhein, respectively, after plasma-treated EC. The concentrations of reactive species (RS), such as H2O2, $${\text{NO}}_{3}^{ - }$$

NO

3

-

, and O3, were found to be higher and the pH value was getting lower in PS after plasma treatment. Detailed analysis of intracellular material leakage, reactive oxygen species (ROS), apoptosis for Candida albicans and observation by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) demonstrated that PAPS, EC and PAEC disrupt the morphological structure of Candida albicans to varying degrees.Additionally, specific analyses on Candida albicans virulence factors, such as adhesion to tissue surfaces, cell surface hydrophobicity (CSH), the transition of yeast-phase cells to mycelium-phase cells, and the secretion of hydrolytic enzymes for Candida albicans were conducted and found to be inhibited after PAPS/EC/PAEC treatment. In our investigation, the inhibitory effects on Candida albicans were ranked from strong to weak as follows: PAEC, EC, PAPS, and PS.
Integration of Genetic Testing and Counseling in Patients With Breast Cancer in a Large, Multisite Community-Based Practice
Authors: Mendenhall Molly A. , Guinigundo Andrew , Davies Dan , Ward Patrick , Drosick David R. , Waterhouse David M. 
Published: June 2023

PURPOSE
Despite data-driven consensus recommendations, there remains significant nonadherence to genetic screening and testing. More than 300,000 patients are diagnosed with breast cancer annually, with one third of these estimated to be eligible for homologous recombination deficiency (HRD)/BRCA testing following National Comprehensive Cancer Network (NCCN) guidelines. Only 35% of eligible patients are referred for genetic counseling.

METHODS
The goal of this project was to apply NCCN guidelines for germline genetic testing to all new patients with breast cancer within a large community oncology practice to improve HRD/BRCA testing. Plan-Do-Study-Act methodology was used, and cycles were built on a proven teaching infrastructure. In cycle 1, providers were educated and directed to use electronic health record (EHR) templates in the setting of an initial diagnosis visit and treatment planning. Discreet data fields were created in the EHR during cycle 2 to streamline and automate the process. Appropriate patients were referred to the genetics team for further evaluation, counseling, and testing. Adherence to the plan was maintained and measured using data analytic reports and chart audits.

RESULTS
Of the 1,203 patients with breast cancer eligible for inclusion, 1,200 (99%) were screened according to NCCN guidelines. Of the screened patients, 631 (52.5%) met the referral/testing criteria. In total, 585 (92.7%) of the 631 were referred to a genetic specialist. Seven percent had previous referrals. A total of 449 (71%) patients were acceptable to genetics referral while 136 (21.5%) patients refused.

CONCLUSION
The implemented methods of education, NCCN guidelines imbedded within provider notes, and discreet data fields in the EHR have proven to be highly effective in screening appropriate patients and ordering subsequent genetic referrals.
Dose-dependent Association of Alcohol Consumption With Obesity and Type 2 Diabetes: Mendelian Randomization Analyses
Authors: Lu Tianyuan , Nakanishi Tomoko , Yoshiji Satoshi , Butler-Laporte Guillaume , Greenwood Celia M T , Richards J Brent 
Published: June 2023

Abstract

Context
Effects of modest alcohol consumption remain controversial. Mendelian randomization (MR) can help to mitigate biases due to confounding and reverse causation in observational studies, and evaluate the potential causal role of alcohol consumption.

Objective
This work aimed to evaluate dose-dependent effect of alcohol consumption on obesity and type 2 diabetes.

Methods
Assessing 408 540 participants of European ancestry in the UK Biobank, we first tested the association between self-reported alcohol intake frequency and 10 anthropometric measurements, obesity, and type 2 diabetes. We then conducted MR analyses both in the overall population and in subpopulations stratified by alcohol intake frequency.

Results
Among individuals having more than 14 drinks per week, a 1-drink-per-week increase in genetically predicted alcohol intake frequency was associated with a 0.36-kg increase in fat mass (SD = 0.03 kg), a 1.08-fold increased odds of obesity (95% CI, 1.06-1.10), and a 1.10-fold increased odds of type 2 diabetes (95% CI, 1.06-1.13). These associations were stronger in women than in men. Furthermore, no evidence was found supporting the association between genetically increased alcohol intake frequency and improved health outcomes among individuals having 7 or fewer drinks per week, as MR estimates largely overlapped with the null. These results withstood multiple sensitivity analyses assessing the validity of MR assumptions.

Conclusion
As opposed to observational associations, MR results suggest there may not be protective effects of modest alcohol consumption on obesity traits and type 2 diabetes. Heavy alcohol consumption could lead to increased measures of obesity as well as increased risk of type 2 diabetes.
Working Paper 43: How corruption threatens the forests of Ukraine
Authors: Hrynyk Yehor , Biletskyi Andrii , Cabrejo le Roux Amanda 
Published: June 2023

This report offers a detailed deep dive into how corruption fuelled illegal logging in Ukraine during the period before the full-scale war. It explains how the Russian invasion has raised the risks of illegal logging, by increasing demand for wood and its relative value as a resource, and by reducing inspections and civil society oversight.
Building on pre-war case studies, selected interviews and a review process with various stakeholders, the report outlines the widespread corruption challenges in Ukraine's forestry sector and proposes relevant interventions in the war and reconstruction contexts.
The report identifies specific corruption patterns linked to three main types of illegal logging:

By private actors such as communities and criminal groups, who can evade justice by corrupting law enforcement officials.
By forest management officials, who sometimes obtain false paperwork to fell trees – thus easing their export abroad.
Following the illegal appropriation of forests through manipulation of land documents.

A significant proportion of wood illegally logged in Ukraine comes with (illegally obtained) permits, so can be "legally" exported to foreign markets in the European Union and elsewhere.
Both governments and the private sector in countries that import wood and/or support Ukraine's reconstruction efforts have a role to play in preventing the illegal destruction of Ukraine's forests.
Treatment of small intestinal bacterial overgrowth: Conventional antibiotic therapy and alternative therapy - probiotics and low FODMAP diet
Authors: Litwiniuk Maria , Zaniuk Marcin , Hurkała Kamil , Antonik Dominika , Denys Barbara , Góra Karolina , Zdziennicki Wojciech , Zimnicki Patryk , Lato Marta , Iberszer Konrad 
Published: June 2023

Introduction and purpose of the study: Small intestinal bacterial overgrowth syndrome (SIBO) is a syndrome characterized by an increased number of bacteria in the small intestine. The condition causes many non-specific symptoms such as diarrhea, abdominal pain and bloating. The purpose of this study is to review the current knowledge regarding treatment options for SIBO.
Methodology: A literature review was conducted based on PubMed, GoogleScholar databases and American College of Gastroenterology (ACG) guidelines.
Current knowledge: SIBO is a heterogeneous syndrome. Symptoms of bacterial overgrowth include bloating, abdominal pain and abnormal bowel motility. In more severe cases, patients may experience malabsorption leading to weight loss and malnutrition. SIBO can occur in healthy individuals, but very often accompanies other conditions. The primary test for diagnosis is non-invasive lactulose or glucose breath tests. For treatment, the antibiotic rifaximin is preferred. It exhibits a broad spectrum of activity and a low toxicity profile. Treatment may also include diet therapy and the use of probiotics.
Summary: SIBO continues to be both a diagnostic and therapeutic problem. Effective treatment includes not only elimination of the bacteria but also treatment of predisposing conditions. Conclusions of the study show a positive effect of rifaximin on the reduction of SIBO symptoms and improvement of patients' quality of life. The use of certain probiotics has a proven effect. According to the currently available literature, the effectiveness of the low-FODMAP diet in SIBO is hypothetical and further studies are needed to unequivocally confirm its efficacy.
Kajian Proporsi Air Kelapa-Sari Daun Kelor (Moringa oleifera) dan Konjac Powder Terhadap Kualitas Fisikokimia dan Sensoris Jelly Drink Kelor
Authors: Adi Seno Mawarno Binardo , Bianca Lewerissa Karina 
Published: June 2023

Masalah stunting (kerdil) telah menjadi persoalan global termasuk di negara Indonesia. Perlunya pemenuhan zat gizi baik gizi makro maupun mikro di fase awal pertumbuhan akan mengurangi risiko terjadinya stunting pada anak. Daun kelor merupakan salah satu komoditas pangan kaya gizi berupa protein, serat, serta berbagai vitamin dan mineral seperti vitamin C, betakaroten, zat besi, dan kalsium. Penelitian ini bertujuan untuk mendapatkan inovasi pangan tinggi zat gizi untuk anak dalam bentuk jelly drink. Metode penelitian eksperimental menggunakan Rancangan Acak Lengkap dua faktorial untuk formulasi jelly drink yaitu rasio air kelapa dan sari daun kelor sebanyak 1:1 dan 1:2 dan konsentrasi konjac powder sebanyak 0,1 %, 0,2% dan 0,3%. Berdasarkan analisis kualitas secara fisik, jelly drink dengan rasio 1:1 dan konsentrasi konjac powder 0,3% memiliki nilai sineresis yang paling baik. Sedangkan secara sensoris, jelly drink dengan perlakuan rasio 1:2 memiliki tingkat penerimaan yang lebih baik secara warna dan penerimaan secara keseluruhan (overall). Berdasarkan total nilai skor keseluruhan parameter fisik dan sensoris, jelly drink dengan proporsi air kelapa: sari daun kelor 1:1 dan konsentrasi konjac powder 0,2% merupakan perlakuan terbaik. Hasil analisis kimia menunjukkan jelly drink daun kelor terbaik memiliki kandungan protein sebesar 2,06% dan vitamin C sebesar 0,77%
Effects of iron supplementation on cognitive development in school-age children: Systematic review and meta-analysis
Authors: Gutema Befikadu Tariku , Sorrie Muluken Bekele , Megersa Nega Degefa , Yesera Gesila Endashaw , Yeshitila Yordanos Gizachew , Pauwels Nele S. , De Henauw Stefaan , Abbeddou Souheila 
Published: June 2023

BackgroundIron deficiency is negatively associated with children’s cognitive development. Evidence showed that iron supplementation improves cognitive development. Nearly 50% of anemia is caused by iron deficiency. Anemia affects more school-age children, at an age where their brain development continues. The aim of this systematic review and meta-analysis is to review the evidence from published randomized controlled trials to evaluate the effects of iron supplementation on cognitive development and function among school-age children.MethodFive databases including MEDLINE, EMBASE, Scopus, Web of Science and CENTRAL were used to search for articles on April 20th, 2021. The search was reconducted on October 13th, 2022 to retrieve new records. Studies were eligible if they included school children 6–12 years of age, were randomized controlled trials, and if they tested iron supplementation and measured cognitive development.ResultThirteen articles were included in the systematic review. Overall, iron supplementation significantly improved intelligence (standardized mean difference, 95% confidence interval) (SMD 0.46, 95%CI: 0.19, 0.73, P<0.001), attention and concentration (SMD 0.44, 95%CI: 0.07, 0.81, P = 0.02) and memory (SMD 0.44, 95%CI: 0.21, 0.67, P <0.001) of school-age children. There was no significant effect of iron supplementation on school achievement of school-age children (SMD 0.06, 95%CI: -0.15, 0.26, P = 0.56). In a subgroup analysis, iron-supplemented children who were anemic at baseline had had better outcomes of intelligence (SMD 0.79, 95%CI: 0.41, 1.16, P = 0.001) and memory (SMD 0.47, 95%CI: 0.13, 0.81; P = 0.006).ConclusionIron supplementation has a significant positive effect on the intelligence, attention and concentration, and the memory of school-age children but there was no evidence on the effect of iron supplementation on their school achievement.
Perceived stress, mental health symptoms, and deleterious behaviors during the transition to college
Authors: Fruehwirth Jane Cooley , Mazzolenis M. Emilia , Pepper Mollie A. , Perreira Krista M. 
Published: June 2023

Background
This study examined associations between different sources of chronic perceived stress and deleterious behaviors (eating disorder symptoms, insufficient sleep, and insufficient vigorous physical activity) among first-year college students.

Methods
The study used data on 885 first-year students (ages 18–20) at a large public university in North Carolina. The prevalence of deleterious behaviors was evaluated. Associations were estimated between different sources of chronic perceived stress (academic, future, peers, friendships, romantic, appearance, health, chronic illness, financial, work, family) and health behaviors after controlling for psychosocial supports and demographics. Moderating effects of gender and moderate-severe anxiety/depression symptoms were also tested.

Results
19% of first-year student reported symptoms of eating disorders, 42% insufficient sleep, and 43% insufficient vigorous physical activity. Perceived chronic stress increased the odds of reporting these deleterious behaviors. These effects were not moderated by gender or moderate-severe anxiety/depression symptoms. Appearance- and health-related stress were associated with eating disorder symptoms; health- and romantic-related stress were associated with insufficient sleep; and health-related stress was associated with insufficient vigorous physical activity.

Limitations
Outcomes were survey-based. The study was based on cross-sectional data from a single university, so the direction of causality cannot be determined, and more work needs to be done to determine whether this would extend to other populations.
Association of Helicobacter Pylori Positivity with Risk of Disease and Mortality
Authors: Wizenty Jonas , Koop Paul-Henry , Clusmann Jan , Tacke Frank , Trautwein Christian , Schneider Kai Markus , Sigal Michael , Schneider Carolin V. 
Published: June 2023

Abstract

Background:

Helicobacter pylori colonizes the human stomach. Infection causes chronic gastritis and increases the risk for gastroduodenal ulcer and gastric cancer. Its chronic colonization in the stomach triggers aberrant epithelial and inflammatory signals, that are also associated with systemic alterations.

Methods:
Using PheWAS analysis in more than 8.000 participants in the community-based UK Biobank we explored the association of H. pylori positivity with gastric and extra gastric disease and mortality in a European country.

Results:
Along with well-established gastric diseases we dominantly found overrepresented cardiovascular, respiratory, and metabolic disorders. Using multivariate analysis, the overall mortality of H. pylori positive participants was not altered, while the respiratory and COVID-19 associated mortality increased. Lipidomic analysis for H. pylori positive participants revealed a dyslipidemic profile with reduced HDL cholesterol and omega-3 fatty acids, which may represent a causative link between infection, systemic inflammation, and disease.

Conclusion:
Our study of H. pylori positivity demonstrates that it plays an organ- and disease entity-specific role in the development of human disease and highlight the importance of further research into the systemic effects of H. pylori infection.
On an effective equation of the reduced Hartree-Fock theory
Authors: Chenn Ilias , Mayboroda Svitlana , Wang Wei , Zhang Shiwen 
Published: June 2023

Abstract
We show that there is a one-to-one correspondence between solutions to the Poisson-landscape equations and the reduced Hartree-Fock equations in the semi-classical limit at low temperature. Moreover, we prove that the difference between the two corresponding solutions is small by providing explicit estimates.
Synthesis and optical characterization of Sr and Ti doped BiFeO3 multiferroics
Authors: Chouhan Pushpender , Dwivedi Rakesh Kumar 
Published: June 2023

Abstract
In this work, Sr and Ti doped BiFeO3 (bismuth ferrite) compositions with dopant x = 0.00 and x = 0.10 have been synthesized by conventional solid-state-reaction method. X-ray diffraction patterns of the pure and Sr and Ti modified BiFeO3 samples with x = 0.10 have shown single phase formation. Rietveld refinement of X-ray diffraction data for both the samples has revealed Rhombohedral structural symmetry with R3c space group. Fourier-transform infrared spectroscopy spectra, recorded in the range 1000–400 cm−1 show shift in the position of a broad hump at higher wave number side with x which may be attributed to the stretching of Bi–O and Fe–O bonds due to doping. UV–visible spectra (ultraviolet-visible spectroscopy) in the range 300–800 nm have revealed a slight increase in the band gap with substitution.
Development of morphology and lattice misfit in modified Ni-base superalloy with Al, Co and Ni additions
Authors: Saenarjhan Nithi , Kiatwisarnkij Napat , Korthamniwet Witchawet , Lothongkum Gobboon , Rojhirunsakool Tanaporn , Nisaratanaporn Ekasit , Horňak Peter , Wangyao Panyawat 
Published: June 2023

Abstract
This research work studied the effect of aluminium, cobalt and nickel additions in superalloys grade GTD-111 and IN-738 on morphology of gamma prime particles and their lattice misfits after subjected to heat treatment and long-term cyclic exposure by using SEM and XRD. It was found that the particles became more cuboidal in shape after heat treatment in modified GTD-111 and IN-738 alloys. When adding 1 wt% aluminium and 6 wt% nickel, larger negative values of lattice misfit were found at −0.57 % and −0.28 %, respectively. However, 6 wt% cobalt addition reduced the negative value of the lattice misfit to −0.20 % in modified GTD-111 and small positive lattice misfit (+0.08 %) was found in modified IN-738. Also, modified GTD-111 alloy shows more spherical shape of the gamma prime precipitates than those in modified IN-738. After long-term cyclic exposure at 1173 K for 1440 ks, it was found that the particles become more spherical shape comparing to those of heat treated ones. The shape of particles in both modified alloys with 1 wt% aluminium and 6 wt% nickel additions maintained more cuboidal compared to others. Furthermore, the effect of 6 wt% cobalt addition is more pronounced for modified IN-738 than that of modified GTD-111.