bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eco-friendly silver nanoparticles (AgNPs) fabricated by green synthesis using Capsicum annum L. extract: biosynthesis, characterization, and antibacterial activity
Authors: Fitriany Erna  Fitriany , Priyoherianto Andri , Panji Ratih Suci  
Published: June 2023

Silver nanoparticles (AgNPs) have many benefits in the health sector, it has antimicrobial and biomedical Activity. AgNPs can be synthesized by using green chemistry or using chemical substances, such as NaBH4. Green synthesis of AgNPs is an environmentally friendly alternative and has cost-effective production. Capsicum annuum L. combined with Saffron extract was used to synthesize AgNPs. The biosynthesis, characterization, and antibacterial activity of AgNPs were studied in this research. The synthesized AgNPs were characterized by UV- Visible spectroscopy (UV-Vis), Fourier- transform Infrared Spectroscopy (FTIR), and Particle Size Analyzer (PSA). The formation of AgNPs was confirmed by optical performance using UV-VIS spectroscopy and showing a peak of AgNPs at 407 nm. Capsicum Annuum L. combined with Saffron extract contained C-H, C-N, and C=O groups. The particle size was characterized using PSA, the size is 37,74 nm. Capsicum Annuum L. combined with Saffron extract has good antibacterial activity.
Keywords: Green Synthesis, AgNPs, Capsicum annuum L, Saffron.
Pengembangan Instrumen Tes Kimia Berbasis Literasi Sains untuk Mengukur Literasi Sains Siswa
Authors: Tari Nurfadillah  , Rina Elvia  , Elvinawati  
Published: June 2023

The purpose of this study was to develop a scientific literacy-based test instrument to measure students' scientific literacy at SMA Negeri 9 Bengkulu City in thermochemistry material. The development model used is the ADDIE model (Analysis, Design, Development, Implementation, Evaluation). The research subjects were classes XI MIPA 3 and XI MIPA 2 at SMA Negeri 9 Bengkulu City for the academic year 2022/2023 which were selected based on a purposive sampling technique with a population of 3 classes, which was then subjected to a homogeneity test so that a homogeneous class was obtained, namely class XI MIPA 2 for large scale test and XI MIPA 3 for small scale test. The research period starts from January to September 2022. The research data was obtained from interviews, expert validation sheets, empirical test analysis, reliability, level of difficulty, discriminating power, and analysis of students' scientific literacy levels. The number of instruments developed is 6 items in the form of essays. The research results were obtained using the Ministep application, so that the items developed were declared valid by the validator with a CVR (Content Validity Ratio) value of at least 0.78 for each question, and the CVI (Content Validity Text) value obtained was 0. 94 with very good category. The results of the empirical validity test were carried out on 15 students of class XI MIPA 3 and obtained 8 valid questions. The developed scientific literacy-based test instrument has a reliability value of 0.85 in the very good reliability category so that it can be used to measure students' scientific literacy level. The results of implementing the development of scientific literacy-based test instruments obtained 1 student who had a high level of scientific literacy, 2 students who had a moderate level of scientific literacy, and 23 students with a scientific literacy level at the nominal scientific Literacy level. The results of the development of scientific literacy-based test instruments have proven to be accurate and reliable so that they can be used to measure students' scientific literacy, especially in thermochemical material.
Keywords: development, chemical test instrumen, scientific literacy, and thermochemistry
Utilização de resíduos de bauxita como filler, adicionado de polipropileno do resíduo de garrafão de água mineral no concreto betuminoso usinado a quente
Authors: Batista Alex Gomes , Picanço Marcelo de Souza 
Published: June 2023

O presente estudo visa avaliar a utilização do resíduo de bauxita, em conjunto com o polipropileno, proveniente dos garrafões de água mineral, na composição do Concreto Betuminoso Usinado à Quente – CBUQ. Para tanto, foram elaboradas composições com três diferentes porcentagens de resíduo de bauxita (3%, 5% e 7%), misturas utilizando apenas o polipropileno, nos teores de (1%, 3% e 5%), e dosagens com substituição de 3% de filler pelo resíduo de bauxita e 3% de polipropileno. Os materiais constituintes foram caracterizados quanto a composição química, física e microestrutural. O resíduo de bauxita foi avaliado quanto aos aspectos de granulometria, microestrutura, pH, massa específica e composição química. Os agregados foram submetidos aos ensaios de massa específica, abrasão, índice de forma e adesividade e, enquadrados na curva granulométrica teórica correspondente à média da “Faixa C” do DNIT. Para o ligante CAP 50/70 foi realizado o ensaio de penetração, ponto de amolecimento e viscosidade. O desempenho das misturas asfálticas foi aferido por meio dos parâmetros do ensaio Marshall e resultados da tração por compressão diametral estática a 25°C mínima MPa. A água proveniente do condicionamento a 60°C de corpos de prova constituídos por resíduo de bauxita foi recolhida e avaliada quanto ao pH e concentrações de ferro e alumínio. Os resultados demonstraram que há perspectiva de melhorar os parâmetros Marshall para diferentes teores de resíduo de bauxita utilizado como filler e polipropileno, criando materiais alternativos na constituição de pavimentos, capazes de conferir propriedades mecânicas satisfatórias ao tráfego, sem contaminação do meio ambiente.
Efeitos da adição de casca de arroz na foto e biodegradação de biopolímeros em pectina termoplastificada
Authors: Belani Juliana , Tessmer Josiane Matias , Almeida Laura Coelho , Vieira Anita Dutra , Oliveira Ana Carolina Salgado de , Alves Marcelo Möller , Borges Soraia Vilela , Cotta Anômora Ariane Rochido dos Santos 
Published: June 2023

O alto consumo de plásticos sintéticos vem trazendo diversos impactos nocivos, dessa forma, o desenvolvimento de embalagens biodegradáveis torna-se importante e necessário. A produção de biopolímeros utilizando compostos como a pectina e a sílica, vem apresentando grande potencial de aplicação. A casca de arroz por ser uma fonte complementar de sílica está sendo usada como reforço mecânico. Este estudo teve como objetivo preparar e caracterizar filmes de pectina incorporados com casca de arroz e sílica, a fim de melhorar suas propriedades com foco na foto e na biodegradação. E assim, avaliar os efeitos da adição desses componentes na permeabilidade à vapor de água (PVA), propriedades mecânicas, espessura, cor, fotodegradação e biodegradação. Os filmes foram caracterizados e os resultados mostraram que a adição da casca de arroz e da sílica fez com que os biopolímeros tivessem diferença de cor perceptível ao olho humano (∆E entre 1,5 e 5,0). As amostras se mostraram amareladas e avermelhadas e com luminosidade intermediária. A incorporação da casca de arroz e sílica provocou aumento na espessura e na PVA. Foi observado que com essa adição, a resistência à tração e o alongamento na ruptura diminuíram, e o módulo de elasticidade aumentou. Os resultados mostraram que os filmes apresentaram alta taxa de biodegradação e baixa taxa de fotodegradação, ou seja, são capazes de resistir a ação da luz sem alterar sua biodegradação. Assim, foi possível observar que os filmes de pectina e casca de arroz ou pectina e sílica possuem viabilidade de aplicação em diversas áreas.
Comparative Eﬀects of Diﬀerent Physiotherapy Programs on Motor Skills of Children with Mild and Moderate Motor Impairment
Authors: Tabarienė Kristina , Sipavičienė Saulė 
Published: June 2023

Background. Children diagnosed with mild or moderate motor impairment not only face impairment of fine motor skills and problems with body balance in daily activities, they are also diagnosed with a decrease in muscle strength. Physiotherapy is prescribed to improve physical condition.
The aim of the study was to determine the effect of different physiotherapy programs on running speed, balance and leg strength in children with mild and moderate motor impairment.
Methods. 30 children (4–6 years old) with mild or moderate motor impairment participated in the study, and were randomly divided into two groups. The control group (n=15) received only conventional physiotherapy, while the experimental group (n=15) received a balance training program on the Abili Balance platform in addition to conventional physiotherapy. The duration of the interventions for both groups was 8 weeks. The subjects’ static and dynamic balance (according to Abili stability index and Berg scale), leg muscle strength (Broad jump) and running speed (Shuttle Run) were assessed before and after the interventions.
Results. After 8 weeks, children in both groups had longer forward jumps and shorter shuttle run test results (p<0.05); balance indicators improved (p<0.05). After the interventions, the postural stability and leg muscle strength of the children in the study group were higher (p<0.05) than in the control group; other indicators did not differ significantly.
Conclusions. Both applied 8-week physiotherapy programs were effective in improving children’s motor skills. Conventional physiotherapy combined with a balance training program was more effective than conventional physiotherapy in improving leg strength and postural stability in children with mild to moderate motor impairment, but not running speed and static and dynamic balance assessed by the Berg test.
Keywords: leg, muscle strength, balance, running speed.
Pengembangan Rancangan Pembelajaran Massive Open and Online Courses (MOOCs) Public Speaking
Authors: Nila Kusuma Windrati  , Isma Dwi Fiani  , Arifah Bintarti  , Asih Irsanti Widuri 
Published: June 2023

Artikel ini menjelaskan hasil penelitian tentang pengembangan rancangan pembelajaran dalam Massive Open and Online Courses (MOOCs) Public Speaking. Penelitian ini dilatarbelakangi oleh hasil evaluasi yang menunjukan bahwa MOOCs Public Speaking dinilai belum optimal dari sisi rancangan pembelajaran program, materi pembelajarannya, hingga tes kompetensi. Hasil penelitian digunakan untuk menyempurnakan program MOOCs Public Speaking yang telah dikembangkan oleh Universitas Terbuka agar memenuhi aspek keabsahan dan kelayakan. Metode penelitian yang digunakan adalah kualitatif dengan teknik pengumpulan data melalui wawancara mendalam dengan pakar public speaking, praktisi public speaking, pakar desain instruksional dan dosen UT pengembang MOOCs. Temuan studi menunjukan bahwa secara ideal, pembelajaran Public Speaking secara jarak jauh tetap membutuhkan praktik secara syncrounus dengan jumlah peserta di satu kelas tidak lebih dari 15 untuk mencapai efektivitas program pembelajaran. Apabila diterapkan pada program MOOCs yang sifatnya masif dan self paced, maka dianggap sulit untuk mengakomodasi kebutuhan pembelajaran MOOCs Public Speaking yang ideal.

This research aims to develop learning designs in Massive Open and Online Courses (MOOCs) of Public Speaking. This research is compiled based on the previous research results, which show that MOOCs Public Speaking is not yet optimal regarding program learning design, learning materials, and competency evaluation. The results of this study will benefit improving the MOOCs Public Speaking program developed by Universitas Terbuka (UT) to meet the feasibility aspect. This research used the research and development method to design a syllabus or learning strategy for the MOOCs Public Speaking program. Data collection techniques were conducted through in-depth interviews with informants, including public speaking experts, public speaking practitioners, instructional design experts and UT lecturers who developed MOOCs. The study findings show that, ideally, distance learning Public Speaking course still requires synchronous mode with no more than 15 participants in one class to achieve the learning program's effectiveness. On the other side, when applied to the massive and self-paced MOOCs program, it is considered challenging to accommodate the ideal learning needs of MOOCs Public Speaking.
Implementation of Aseptic Dispensing for Non-Cytostatic Injectable Drugs in the Internal Medicine Inpatient Ward of 'X' Hospital, West Java
Authors: Sari Novita , Sumarny Ros , Laksmitawati Dian R. , Nurcholis Waras 
Published: June 2023

Aseptic Dispensing activity is a procedure to minimize pharmaceutical preparations from the threats of pyrogens and contaminants. This study aims to determine the implementation of aseptic dispensing for non-cytostatic injectable drugs and the sterility of intravenous mixed preparations in the Internal Medicine Inpatient Ward of 'X' hospital, West Java for the period January - February 2022. This was a descriptive observational prospective study with a cross sectional approach. Researchers made direct observations of dispensing personnel, room and equipment as well as the process of aseptic dispensing activities including the stages of preparation, mixing, storage and disposal as well as sterility test of aseptic dispensing products. Based on the study results, it was obtained that of the 150 intravenous mixed preparations collected, there were 40 activities of diluting intravenous preparations, 100 activities of packaging into ready-to-use preparations and 10 activities of mixing intravenous preparations into infusion fluids, room suitability by 74%, preparations arrangement procedure by 68%, mixing procedure by 44%, storage procedure by 100% and disposal procedure by 63%. It can be concluded that the aseptic dispensing of non-cytostatic injection drugs in the internal medicine inpatient ward of 'X' hospital, West Java was not in accordance with the guidelines, especially at the mixing procedure stage (≤50). Compliance of dispensing personnel and room cleanliness during the process of mixing intravenous preparations need to be considered. The result of the identification of contamination during the aseptic dispensing activity of non-cytostatic injectable drugs showed that 1 in 150 samples (0.66%) was contaminated.
Early inhalant allergen sensitization at component level: an analysis in atopic Dutch children
Authors: Landzaat Lonneke J. , Emons Joyce A. M. , Sonneveld Laura J. H. , Schreurs Marco W. J. , Arends Nicolette J. T. 
Published: June 2023

BackgroundAllergic rhinitis is a common respiratory disease in children and sensitization to inhalant allergens plays a significant role in its development. However, limited knowledge exists regarding sensitization profiles of inhalant allergen components in atopic children, particularly in the very young individuals. Understanding these profiles could provide insights into the early development of allergic rhinitis. The objective of this cross-sectional retrospective study was to evaluate the IgE-sensitization profiles to multiple inhalant allergen components and their clinical relevance in Dutch atopic children, with specific focus on children under the age of 4 years.MethodsA total of 243 atopic children were included in the study and sensitization profiles were analyzed using multiplex microarray analysis (ISAC). Clinical information was obtained from records of a pediatric allergy outpatient clinic between 2011 and 2020. Specific IgE responses to inhalation allergen components from five allergen sources (grass pollen, tree pollen, house dust mite, cat and dog), were examined. The study encompassed children of different age groups and compared those with and without symptoms.ResultsThe results demonstrated that sensitization to inhalant allergen components was present in 92% of the cohort. Sensitization was already evident at a young age (87%), including infancy, with a rapid increase in prevalence after 1 year of age. House dust mite emerged as the most predominant sensitizing allergen in early childhood, followed by tree pollen in later years. Sensitization patterns were similar between symptomatic and asymptomatic children, although symptomatic children exhibited higher frequencies and values. The sensitization profiles in very young children were comparable to those of children across all age groups.ConclusionThese findings highlight the presence of sensitization to inhalant allergen components and the early onset of allergic rhinitis before the age of 4, including infancy, in Dutch atopic children. Notable allergen molecules in Dutch atopic children under the age of 4 years include Bet v 1, Fel d 1, Der f 1, Der p 1, Der p 10 and Phl p 4, with house dust mite sensitization being the most common among Dutch infants. Moreover, the prevalence of sensitization to inhalant allergens in this Dutch cohort surpassed that of general European populations, emphasizing the importance of early assessment and management of allergic rhinitis in young atopic children.
New anti-diabetic agents for the treatment of non-alcoholic fatty liver disease: a systematic review and network meta-analysis of randomized controlled trials
Authors: Kongmalai Tanawan , Srinonprasert Varalak , Anothaisintawee Thunyarat , Kongmalai Pinkawas , McKay Gareth , Attia John , Thakkinstian Ammarin 
Published: June 2023

ObjectivesThis network meta-analysis aims to compare the efficacy and safety of new anti-diabetic medications for the treatment of non-alcoholic fatty liver disease (NAFLD).Materials and methodsPubMed and Scopus were searched from inception to 27th March 2022 to identify all randomized controlled trials (RCTs) in NAFLD patients. Outcomes included reductions in intrahepatic steatosis (IHS) and liver enzyme levels. The efficacy and safety of DPP-4 inhibitors, GLP-1 agonists, SGLT-2 inhibitors, and other therapies were indirectly compared using a NMA approach. Unstandardized mean difference (USMD) with 95% confidence intervals (CI) were calculated.Results2,252 patients from 31 RCTs were included. “Add-on” GLP-1 agonists with standard of care (SoC) treatment showed significantly reduced IHS compared to SoC alone [USMD (95%CI) -3.93% (-6.54%, -1.33%)]. Surface under the cumulative ranking curve (SUCRA) identified GLP-1 receptor agonists with the highest probability to reduce IHS (SUCRA 88.5%), followed by DPP-4 inhibitors (SUCRA 69.6%) and pioglitazone (SUCRA 62.2%). “Add-on” GLP-1 receptor agonists were also the most effective treatment for reducing liver enzyme levels; AST [USMD of -5.04 (-8.46, -1.62)], ALT [USMD of -9.84 (-16.84, -2.85)] and GGT [USMD of -15.53 (-22.09, -8.97)] compared to SoC alone. However, GLP-1 agonists were most likely to be associated with an adverse event compared to other interventions.ConclusionGLP-1 agonists may represent the most promising anti-diabetic treatment to reduce hepatic steatosis and liver enzyme activity in T2DM and NAFLD patients. Nevertheless, longer-term studies are required to determine whether this delays progression of liver cirrhosis in patients with NAFLD and T2DM.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021259336.1.
Revealing ecotype influences on Cistanche sinensis: from the perspective of endophytes to metabolites characteristics
Authors: Zhang Min , Miao Yujing , Zhang Xinke , Sun Xiao , Li Minhui , Huang Linfang 
Published: June 2023

IntroductionPlant microorganism is critical to plant health, adaptability, and productive forces. Intriguingly, the metabolites and microorganisms can act upon each other in a plant. The union of metabolomics and microbiome may uncover the crucial connections of the plant to its microbiome. It has important benefits for the agricultural industry and human being health, particularly for Chinese medical science investigation.MethodsIn this last 2 years study, on the strength of the UPLC–MS/MS detection platform, we accurately qualitatively, and quantitatively measured the Cistanche sinensis fleshy stems of two ecotypes. Thereafter, through high-throughput amplicon sequencing 16S/ITS sequences were procured.ResultsPhGs metabolites including echinacoside, isoacteoside, and cistanoside A were significantly downregulated at two ecotypes of C. sinensis. Add up to 876 metabolites were monitored and 231 differential metabolites were analyzed. Further analysis of 34 core differential metabolites showed that 15 compounds with up-regulated belonged to phenolic acids, flavonoids, and organic acids, while 19 compounds with down-regulated belonged to phenolic acids, flavonoids, alkaloids, amino acids, lipids, and nucleotides. There was no noteworthy discrepancy in the endophytic bacteria’s α and β diversity between sandy and loam ecotypes. By comparison, the α and β diversity of endophytic fungi was notably distinct. The fungal community of the loam ecotype is more abundant than the sandy ecotype. However, there were few such differences in bacteria. Most abundant genera included typical endophytes such as Phyllobacterium, Mycobacterium, Cistanche, Geosmithia, and Fusarium. LEfSe results revealed there were 11 and 20 biomarkers of endophytic bacteria and fungi in C. sinensis at two ecotypes, respectively. The combination parsing of microflora and metabolites indicated noteworthy relativity between the endophytic fungal communities and metabolite output. Key correlation results that Anseongella was positive relation with Syringin, Arsenicitalea is negative relation with 7-methylxanthine and Pseudogymnoascus is completely positively correlated with nepetin-7-O-alloside.DiscussionThe aim of this research is: (1) to explore firstly the influence of ecotype on C. sinensis from the perspective of endophytes and metabolites; (2) to investigate the relationship between endophytes and metabolites. This discovery advances our understanding of the interaction between endophytes and plants and provides a theoretical basis for cultivation of C. sinensis in future.
Evaluation of the effectiveness and mechanism of action of the Chang-Kang-Fang formula combined with bifid triple viable capsules on diarrhea-predominant irritable bowel syndrome
Authors: Sun Jing , Zhang Mengqiu , Liu Wei , Liu Youqian , Zhang Dongjian , Fan Xinyu , Zhang Jian , Li Tian , Lu Min 
Published: June 2023

IntroductionThe Chang-Kang-Fang (CKF) formula, a traditional Chinese herbal formula, can decrease serotonin (5-HT) levels and treat irritable bowel syndrome (IBS). Probiotics have a better synergistic effect on diarrhea-predominant IBS (IBS-D) when combined with 5-HT3 receptor antagonists. The present study aimed to elucidate the efficacy and the mechanisms of action of the CKF formula combined with bifid triple viable capsules (PFK) against IBS-D.MethodsThe rat models of IBS-D were induced by gavage with senna decoction plus restraint stress. The CKF formula, PFK and their combination were administered to the rats. Their effects were evaluated based on general condition of the rats and the AWR score. The levels of 5-HT and fos protein in the colon and hippocampus were measured by immunohistochemistry. The levels of SP and VIP, as well as ZO-1 and occludin in the colon, were determined by enzyme-linked immunosorbent assay and immunohistochemistry. The intestinal microbiota in faeces was analyzed by 16S rRNA high-throughput sequencing.ResultsThe results showed that the oral CKF formula combined with PFK (CKF + PFK) could significantly relieve the symptoms of IBS-D, including elevating the weight rate and decreasing the AWR score. Compared with the MC group, administration of CKF + PFK significantly reduced the expression of fos in the colon and hippocampus and that of 5-HT, SP and VIP in the colon and increased the levels of 5-HT in the hippocampus and ZO-1 and occludin in the colon. The above indexes exhibited statistical significance in the CKF + PFK group relative to those in the other groups. Moreover, treatment with CKF + PFK improved the diversity of intestinal microbiota and the abundance of Firmicutes, Lachnospiraceae and Ruminococcaceae but decreased those of Bacteroidetes and Prevotellaceae.ConclusionsThe CKF formula combined with PFK may have a synergistic effect on IBS-D by slowing gastrointestinal motility, lowering visceral hypersensitivity, enhancing the intestinal barrier function and modulating the composition of intestinal microbiota.