bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fulvestrant plus palbociclib in advanced or metastatic hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer after fulvestrant monotherapy: Japan Breast Cancer Research Group-M07 (FUTURE trial)
Authors: Watanabe Kenichi , Niikura Naoki , Kikawa Yuichiro , Oba Mari , Kobayashi Kokoro , Tada Hiroshi , Ozaki Shinji , Toh Uhi , Yamamoto Yutaka , Tsuneizumi Michiko , Okuno Toshitaka , Iwakuma Nobutaka , Takeshita Takashi , Iwamoto Takayuki , Ishiguro Hiroshi , Masuda Norikazu , Saji Shigehira 
Published: April 2023

Abstract
Purpose
The combination of cyclin-dependent kinase 4/6 inhibitors and endocrine therapy is a standard treatment for hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC); however, their toxicities and financial burden are major issues, especially for prolonged treatment. We investigated fulvestrant plus palbociclib in patients with HR-positive MBC resistant to fulvestrant monotherapy.

Methods
Patients who initially received fulvestrant as their first- or second-line endocrine therapy were assigned to group A. Patients with disease progression during fulvestrant monotherapy who subsequently received fulvestrant plus palbociclib were assigned to group B. The primary endpoint was progression-free survival (PFS1) in group B. We set the threshold median PFS of 5 months (null hypothesis).

Results
Between January 2018 and February 2020 we enrolled 167 patients in group A (January 2018–February 2020) from 55 institutions, of whom 72 subsequently received fulvestrant plus palbociclib and were enrolled in group B. The median follow-up was 23.8 and 8.9 months in groups A and B, respectively. The median PFS in group B (combination therapy) was 9.4 (90% confidence interval [CI]: 6.9–11.2) months (p < 0.001). This was 25.7 (90% CI: 21.2–30.3) months in group A (fulvestrant monotherapy). The TTF in group B was 7.2 (90% CI: 5.5–10.4) months. In the post-hoc analysis, the median PFS1 in group B among patients with longer-duration fulvestrant monotherapy (> 1 year) was longer than that of patients with shorter-duration monotherapy (≤ 1 year) (11.3 vs. 7.6 months). No new toxicities were observed.

Conclusion
Our findings suggest that palbociclib plus fulvestrant after disease progression despite fulvestrant monotherapy is potentially safe and effective in patients with HR-positive/HER2-negative advanced MBC.
Impact of diabetes on surgery and radiotherapy for breast cancer
Authors: Lawrenson Ross , Lao Chunhuan , Stanley James , Campbell Ian , Krebs Jeremy , Meredith Ineke , Koea Jonathan , Teng Andrea , Sika-Paotonu Dianne , Stairmand Jeannine , Gurney Jason 
Published: April 2023

Abstract
Purposes
This study aims to examine whether diabetes has an impact on the use of surgery and adjuvant radiotherapy in treating women with localised breast cancer.

Methods
Women diagnosed with stage I–III breast cancer between 2005 and 2020 were identified from Te Rēhita Mate Ūtaetae—Breast Cancer Foundation New Zealand National Register, with diabetes status determined using New Zealand’s Virtual Diabetes Register. The cancer treatments examined included breast conserving surgery (BCS), mastectomy, breast reconstruction after mastectomy, and adjuvant radiotherapy after BCS. Logistic regression modelling was used to estimate the adjusted odds ratio (OR) and 95% confidence interval (95% CI) of having cancer treatment and treatment delay (> 31 days) for patients with diabetes at the time of cancer diagnosis compared to patients without diabetes.

Results
We identified 25,557 women diagnosed with stage I–III breast cancer in 2005–2020, including 2906 (11.4%) with diabetes. After adjustment for other factors, there was no significant difference overall in risk of women with diabetes having no surgery (OR 1.12, 95% CI 0.94–1.33), although for patients with stage I disease not having surgery was more likely (OR 1.45, 95% CI 1.05–2.00) in the diabetes group. Patients with diabetes were more likely to have their surgery delayed (adjusted OR of 1.16, 95% CI 1.05–1.27) and less likely to have reconstruction after mastectomy compared to the non-diabetes group—adjusted OR 0.54 (95% CI 0.35–0.84) for stage I cancer, 0.50 (95% CI 0.34–0.75) for stage II and 0.48 (95% CI 0.24–1.00) for stage III cancer.

Conclusions
Diabetes is associated with a lower likelihood of receiving surgery and a greater delay to surgery. Women with diabetes are also less likely to have breast reconstruction after mastectomy. These differences need to be taken in to account when considering factors that may impact on the outcomes of women with diabetes especially for Māori, Pacific and Asian women.
Morphokinetic parameters of mouse oocyte meiotic maturation and cumulus expansion are not affected by reproductive age or ploidy status
Authors: Suebthawinkul Chanakarn , Babayev Elnur , Lee Hoi Chang , Duncan Francesca E. 
Published: April 2023

Abstract
Introduction
Morphokinetic analysis using a closed time-lapse monitoring system (EmbryoScope + ™) provides quantitative metrics of meiotic progression and cumulus expansion. The goal of this study was to use a physiologic aging mouse model, in which egg aneuploidy levels increase, to determine whether there are age-dependent differences in morphokinetic parameters of oocyte maturation.

Methods
Denuded oocytes and intact cumulus-oocyte complexes (COCs) were isolated from reproductively young and old mice and in vitro matured in the EmbryoScope + ™. Morphokinetic parameters of meiotic progression and cumulus expansion were evaluated, compared between reproductively young and old mice, and correlated with egg ploidy status.

Results
Oocytes from reproductively old mice were smaller than young counterparts in terms of GV area (446.42 ± 4.15 vs. 416.79 ± 5.24 µm2, p < 0.0001) and oocyte area (4195.71 ± 33.10 vs. 4081.62 ± 41.04 µm2, p < 0.05). In addition, the aneuploidy incidence was higher in eggs with advanced reproductive age (24–27% vs. 8–9%, p < 0.05). There were no differences in the morphokinetic parameters of oocyte maturation between oocytes from reproductively young and old mice with respect to time to germinal vesicle breakdown (GVBD) (1.03 ± 0.03 vs. 1.01 ± 0.04 h), polar body extrusion (PBE) (8.56 ± 0.11 vs. 8.52 ± 0.15 h), duration of meiosis I (7.58 ± 0.10 vs. 7.48 ± 0.11 h), and kinetics of cumulus expansion (0.093 ± 0.002 vs. 0.089 ± 0.003 µm/min). All morphokinetic parameters of oocyte maturation were similar between euploid and aneuploid eggs irrespective of age.

Conclusion
There is no association between age or ploidy and the morphokinetics of mouse oocyte in vitro maturation (IVM). Future studies are needed to evaluate whether there is an association between morphokinetic dynamics of mouse IVM and embryo developmental competence.
The association between neighborhood conditions and weight loss among older adults living in a large urban city
Authors: Kim Sage J. , Blesoff Jamine R. , Tussing-Humphrys Lisa , Fitzgibbon Marian L. , Peterson Caryn E. 
Published: April 2023

AbstractTo elucidate the role of neighborhood walkability and crime on weight loss, we examined data from older adults residing in Chicago who participated in a randomized controlled trial lifestyle intervention. Controlling for individual demographic characteristics and the intervention assignment, the neighborhood homicide rate was significantly associated with weight change. Participants who resided in neighborhoods above the 50th percentile of homicide rate actually gained weight between pre- and post-intervention. On the other hand, there was no significant relationship between the level of walkability and weight loss. Our findings suggest that the social environment related to neighborhood crime may play a more important role in weight loss than the built environment, such as walkability. Urban characteristics related to walkability, such as sidewalks, may increase physical activity, however, interventions aiming to increase physical activity to promote weight loss will benefit by addressing the neighborhood social environment that determines how people navigate space.
“I was Treated by the Program, the Therapist, and Myself”: Feasibility of an Internet-Based Treatment Program for Gambling Disorder
Authors: Stenbro Anna Westh , Moldt Stine , Eriksen Jakob Winther , Frostholm Lisbeth 
Published: April 2023

AbstractThe majority of people with problematic gambling behavior never seek or receive professional help. Internet-based treatment approaches have been shown to help patients overcome practical and psychological barriers associated with face-to-face therapy. In this uncontrolled pilot study, we explored the feasibility of the eight-module therapist-guided internet-based treatment program SpilleFri (“Free from Gambling”) for patients with gambling disorder (GD). We included 24 patients seeking treatment at a Danish hospital-based treatment clinic. The focus of the feasibility study was evaluation of recruitment and retention rates, data completion rates, treatment response, satisfaction, and program utility. In addition, a series of semi-structured interviews were conducted to explore patient-perceived acceptability and potential barriers to treatment completion and positive outcome. Treatment acceptability among therapists was examined in a focus group interview. Sixteen of the included patients completed the program, yielding an acceptable treatment dropout rate (29.17%), and 82.35% of treatment completers provided full data at all assessment points. Overall, patients were satisfied with the treatment received, and patient interviews highlighted multiple psychological as well as practical benefits associated with the treatment form and content. Patients with more severe gambling symptoms at baseline might be more likely to drop out before treatment completion than patients with less severe symptoms. The results suggest that SpilleFri may be a feasible alternative to face-to-face treatment for GD. However, the uncontrolled design and small sample size of the study limit the robustness of the findings. In the future, the effect of SpilleFri treatment should be examined in a randomized controlled trial.Clinical trial registrations: The study protocol was prospectively registered at clinicaltrials.gov (TRN: NCT05051085; registration date: September 21, 2021).
Learning semantic ambiguities for zero-shot learning
Authors: Hanouti Celina , Le Borgne Hervé 
Published: April 2023

AbstractZero-shot learning (ZSL) aims at recognizing classes for which no visual sample is available at training time. To address this issue, one can rely on a semantic description of each class. A typical ZSL model learns a mapping between the visual samples of seen classes and the corresponding semantic descriptions, in order to do the same on unseen classes at test time. State of the art approaches rely on generative models that synthesize visual features from the prototype of a class, such that a classifier can then be learned in a supervised manner. However, these approaches are usually biased towards seen classes whose visual instances are the only one that can be matched to a given class prototype. We propose a regularization method that can be applied to any conditional generative-based ZSL method, by leveraging only the semantic class prototypes. It learns to synthesize discriminative features for possible semantic description that are not available at training time, that is the unseen ones. The approach is evaluated for ZSL and GZSL on four datasets commonly used in the literature, either in inductive or transductive settings, with results on-par or above state of the art approaches. The code is available athttps://github.com/hanouticelina/lsa-zsl.
Intertextual Potential and the Reader in the Bevis Tradition: Boeve de Haumtone, Bevis of Hampton and Beuve de Hantonne
Authors: Bateman Mary 
Published: April 2023

AbstractThis article investigates the role that reader-oriented, unlimited intertextuality – that is, intertextual references only as perceived or even mis-perceived by readers – might have had to play in the transmission, adaptation, and development of the Bevis of Hampton narratives across English and Francophone traditions. In recent years, a number of studies have demonstrated the importance of the multi-text manuscript as a medium for texts to be integrated into new reading communities, and I therefore use multi-text Bevis manuscripts as a starting point for my enquiry. In particular, this article focuses on an Anglo-NormanBoeve de Haumtonemanuscript (Leuven, Universiteitsbibliotheek, MS G. 170 or the ‘Firmin-Didot manuscript’, now lost), an EnglishBevis of Hamptonmanuscript (British Library, Egerton MS 2862) and a copy of the so-called “first version” of the continental FrenchBeuve de Haumtone(Bibliothèque nationale de France MS Fr. 25516). Beginning with the “intratexts” that occur within the confines of the Firmin-Didot codex, this article moves forward to consider, in more hypothetical terms, the different textual encyclopedias that may have been available to the historic readers of Bevis manuscripts, and the ways in which readerly understandings (and misunderstandings) of a text’s intertextuality could prompt new narrative branches to sprout forth, and eventually lead to the emergence of new traditions.
An algebraically stabilized method for convection–diffusion–reaction problems with optimal experimental convergence rates on general meshes
Authors: Knobloch Petr 
Published: April 2023

AbstractAlgebraically stabilized finite element discretizations of scalar steady-state convection–diffusion–reaction equations often provide accurate approximate solutions satisfying the discrete maximum principle (DMP). However, it was observed that a deterioration of the accuracy and convergence rates may occur for some problems if meshes without local symmetries are used. The paper investigates these phenomena both numerically and analytically and the findings are used to design a new algebraic stabilization called Symmetrized Monotone Upwind-type Algebraically Stabilized (SMUAS) method. It is proved that the SMUAS method is linearity preserving and satisfies the DMP on arbitrary simplicial meshes. Moreover, numerical results indicate that the SMUAS method leads to optimal convergence rates on general simplicial meshes.
Drawing an Angry Perpetrator and a Sad Target: Children’s Understanding of Emotions of School Bullying Perpetrators and Targets
Authors: Bonoti Fotini , Andreou Eleni , Mantzari Sofia , Tsoungou Varvara 
Published: April 2023

Abstract
The present study aimed to investigate school-aged children’s understanding of emotions of perpetrators and targets of school bullying and whether these vary as a function of children’s participant role in a bullying episode. One hundred seventy-six boys and girls, with a mean age of 11 years and 3 months, participated in the study. They were asked to match emotions felt by the perpetrator and target in an emotional scenario and in a drawing task, while their own participant role in a bullying episode was assessed through a series of short individual scales. Results showed that overall children associated anger and happiness with the perpetrator, while sadness and fear with the target. Moreover, children’s understanding of emotions of school bullying perpetrators and targets was found to be related with their scores in Bullying, Victimization, Defender, and Assistant scales. Results are discussed in relation to their possible contribution in comprehending the dynamics of bullying, by highlighting how understanding of specific emotions of perpetrators and targets is related to involvement in bullying.
Predictors of response to cognitive behavioural therapy (CBT) for individuals with obsessive-compulsive disorder (OCD): a systematic review
Authors: McDonald Sarah , Melkonian Maral , Karin Eyal , Dear Blake F. , Titov Nickolai , Wootton Bethany M. 
Published: April 2023

AbstractBackground:Cognitive behavioural therapy (CBT) is considered the first-line treatment for obsessive-compulsive disorder (OCD). However, some individuals with OCD remain symptomatic following CBT, and therefore understanding predictors of outcome is important for informing treatment recommendations.Aims:The current study aimed to provide the first synthesis of predictors of outcome following CBT for OCD in adults with a primary diagnosis of OCD, as classified by DSM-5.Method:Eight studies (n=359; mean age range=29.2–37.7 years; 55.4% female) were included in the systematic review.Results:Congruent with past reviews, there was great heterogeneity of predictors measured across the included studies. Therefore, a narrative synthesis of findings was conducted. Findings from this systematic review indicated that some OCD-related pre-treatment variables (i.e. pre-treatment severity, past CBT treatment, and levels of avoidance) and during treatment variables (i.e. poor working alliance and low treatment adherence) may be important to consider when making treatment recommendations. However, the results also indicate that demographic variables and psychological co-morbidities may not be specific predictors of treatment response.Conclusions:These findings add to the growing body of literature on predictors of CBT treatment outcomes for individuals with OCD.
Improving poxvirus-mediated antitumor immune responses by deleting viral cGAMP-specific nuclease
Authors: Riederer Stephanie , del Canizo Ana , Navas Javier , Peter Marlowe G. , Link Ellen K. , Sutter Gerd , Rojas Juan J. 
Published: April 2023

AbstractcGAMP-specific nucleases (poxins) are a recently described family of proteins dedicated to obstructing cyclic GMP-AMP synthase signaling (cGAS), an important sensor triggered by cytoplasmic viral replication that activates type I interferon (IFN) production. The B2R gene of vaccinia viruses (VACV) codes for one of these nucleases. Here, we evaluated the effects of inactivating the VACV B2 nuclease in the context of an oncolytic VACV. VACV are widely used as anti-cancer vectors due to their capacity to activate immune responses directed against tumor antigens. We aimed to elicit robust antitumor immunity by preventing viral inactivation of the cGAS/STING/IRF3 pathway after infection of cancer cells. Activation of such a pathway is associated with a dominant T helper 1 (Th1) cell differentiation of the response, which benefits antitumor outcomes. Deletion of the B2R gene resulted in enhanced IRF3 phosphorylation and type I IFN expression after infection of tumor cells, while effective VACV replication remained unimpaired, both in vitro and in vivo. In syngeneic mouse tumor models, the absence of the VACV cGAMP-specific nuclease translated into improved antitumor activity, which was associated with antitumor immunity directed against tumor epitopes.
Clinical and genetic analysis further delineates the phenotypic spectrum of ALDH1A3-related anophthalmia and microphthalmia
Authors: Kesim Yesim , Ceroni Fabiola , Damián Alejandra , Blanco-Kelly Fiona , Ayuso Carmen , Williamson Kathy , Paquis-Flucklinger Véronique , Bax Dorine A , Plaisancié Julie , Rieubland Claudine , Chamlal Mostafa , Cortón Marta , Chassaing Nicolas , Calvas Patrick , Ragge Nicola K 
Published: April 2023

AbstractBiallelic pathogenic variants in ALDH1A3 are responsible for approximately 11% of recessively inherited cases of severe developmental eye anomalies. Some individuals can display variable neurodevelopmental features, but the relationship to the ALDH1A3 variants remains unclear. Here, we describe seven unrelated families with biallelic pathogenic ALDH1A3 variants: four compound heterozygous and three homozygous. All affected individuals had bilateral anophthalmia/microphthalmia (A/M), three with additional intellectual or developmental delay, one with autism and seizures and three with facial dysmorphic features. This study confirms that individuals with biallelic pathogenic ALDH1A3 variants consistently manifest A/M, but additionally display neurodevelopmental features with significant intra- and interfamilial variability. Furthermore, we describe the first case with cataract and highlight the importance of screening ALDH1A3 variants in nonconsanguineous families with A/M.
Heat transfer of generalized second grade fluid with MHD, radiation and exponential heating using Caputo–Fabrizio fractional derivatives approach
Authors: Sehra Sehra , Noor Afshan , Haq Sami Ul , Jan Saeed Ullah , Khan Ilyas , Mohamed Abdullah 
Published: April 2023

AbstractThe aim of the present work is to apply the Caputo–Fabrizio fractional derivative to the heat transformation of unsteady incompressible second grade fluid. The effects of magneto hydro dynamic and radiation are analyzed. In governing equation of heat transfer nonlinear radiative heat is examined. Exponential heating phenomena is considered at boundary. Firstly, the dimensional governing equations with the initial & boundary conditions are converted into non-dimensional form. Exact analytical solutions are obtained for dimensionless fractional governing equations which consist of momentum and energy equations by using Laplace transform method. Special cases are investigated of the obtained solutions and it is noticed that some well-known results are achieved published in literature from these special cases. At the end, for graphical illustration the influences of different physical parameters like radiation, Prandtl, fractional parameter, Grashof numbers and Magneto hydro dynamic are checked graphically.
Machine learning algorithm to predict mortality in critically ill patients with sepsis-associated acute kidney injury
Authors: Li Xunliang , Wu Ruijuan , Zhao Wenman , Shi Rui , Zhu Yuyu , Wang Zhijuan , Pan Haifeng , Wang Deguang 
Published: April 2023

Abstract
This study aimed to establish and validate a machine learning (ML) model for predicting in-hospital mortality in patients with sepsis-associated acute kidney injury (SA-AKI). This study collected data on SA-AKI patients from 2008 to 2019 using the Medical Information Mart for Intensive Care IV. After employing Lasso regression for feature selection, six ML approaches were used to build the model. The optimal model was chosen based on precision and area under curve (AUC). In addition, the best model was interpreted using SHapley Additive exPlanations (SHAP) values and Local Interpretable Model-Agnostic Explanations (LIME) algorithms. There were 8129 sepsis patients eligible for participation; the median age was 68.7 (interquartile range: 57.2–79.6) years, and 57.9% (4708/8129) were male. After selection, 24 of the 44 clinical characteristics gathered after intensive care unit admission remained linked with prognosis and were utilized developing ML models. Among the six models developed, the eXtreme Gradient Boosting (XGBoost) model had the highest AUC, at 0.794. According to the SHAP values, the sequential organ failure assessment score, respiration, simplified acute physiology score II, and age were the four most influential variables in the XGBoost model. Individualized forecasts were clarified using the LIME algorithm. We built and verified ML models that excel in early mortality risk prediction in SA-AKI and the XGBoost model performed best.