bluuebunny/crossref_metadata_2025_split huggingface dataset:
Piezo robotic hand for motion manipulation from micro to macro
Authors: Zhang Shijing , Liu Yingxiang , Deng Jie , Gao Xiang , Li Jing , Wang Weiyi , Xun Mingxin , Ma Xuefeng , Chang Qingbing , Liu Junkao , Chen Weishan , Zhao Jie 
Published: January 2023

AbstractMultiple degrees of freedom (DOFs) motion manipulation of various objects is a crucial skill for robotic systems, which relies on various robotic hands. However, traditional robotic hands suffer from problems of low manipulation accuracy, poor electromagnetic compatibility and complex system due to limitations in structures, principles and transmissions. Here we present a direct-drive rigid piezo robotic hand (PRH) constructed on functional piezoelectric ceramic. Our PRH holds four piezo fingers and twelve motion DOFs. It achieves high adaptability motion manipulation of ten objects employing pre-planned functionalized hand gestures, manipulating plates to achieve 2L (linear) and 1R (rotary) motions, cylindrical objects to generate 1L and 1R motions and spherical objects to produce 3R motions. It holds promising prospects in constructing multi-DOF ultra-precision manipulation devices, and an integrated system of our PRH is developed to implement several applications. This work provides a new direction to develop robotic hand for multi-DOF motion manipulation from micro scale to macro scale.
Target templates and the time course of distractor location learning
Authors: Hanne Aylin A. , Tünnermann Jan , Schubö Anna 
Published: January 2023

AbstractWhen searching for a shape target, colour distractors typically capture our attention. Capture is smaller when observers search for a fixed target that allows for a feature-specific target template compared to a varying shape singleton target. Capture is also reduced when observers learn to predict the likely distractor location. We investigated how the precision of the target template modulates distractor location learning in an additional singleton search task. As observers are less prone to capture with a feature-specific target, we assumed that distractor location learning is less beneficial and therefore less pronounced than with a mixed-feature target. Hierarchical Bayesian parameter estimation was used to fit fine-grained distractor location learning curves. A model-based analysis of the time course of distractor location learning revealed an effect on the asymptotic performance level: when searching for a fixed-feature target, the asymptotic distractor cost indicated smaller distractor interference than with a mixed-feature target. Although interference was reduced for distractors at the high-probability location in both tasks, asymptotic distractor suppression was less pronounced with fixed-feature compared to mixed-feature targets. We conclude that with a more precise target template less distractor location learning is required, likely because the distractor dimension is down-weighted and its salience signal reduced.
Synthesis, antimicrobial activity and molecular docking studies of spiroquinoline-indoline-dione and spiropyrazolo-indoline-dione derivatives
Authors: Gul Melek , Turk Celikoglu Emine , Idil Onder , Tas Gamze , Pelit Emel 
Published: January 2023

AbstractSpiro[benzo[h]quinoline-7,3′-indoline]diones and spiro[indoline-3,4′-pyrazolo[3,4-b]quinoline]diones were efficiently synthesized via one-pot multi-component reactions under ultrasound-promoted conditions. Spiro[benzo[h]quinoline-7,3′-indoline]dione derivatives were successfully developed by the reaction of isatins, naphthalene-1-amine and 1,3-dicarbonyl compounds. The spiro[indoline-3,4′-pyrazolo[3,4-b]quinoline]dione derivatives were prepared by the reaction of isatins, 5-amino-1-methyl-3-pheylpyrazole, and 1,3-dicarbonyl compounds by using ( ±)-camphor-10-sulfonic acid as a catalyst in H2O/EtOH (3:1 v/v) solvent mixture. The antibacterial activity of the synthesized compounds was evaluated against,Enterococcus faecalis,Staphylococcus aureusandCandida albicans. Compounds 4b, 4h, and 6h showed the strongest antimicrobial activity toward both bacteria. The MIC values of these compounds ranged from 375–3000 µg/mL. The effect of these compounds (4b, 4h, 6h) as a function of applied dose and time was investigated by a kinetic study, and the interaction with these antimicrobial results was simulated by a molecular docking study. We also used the docking approach with Covid-19 since secondary bacterial infections. Docking showed that indoline-quinoline hybrid compounds 4b and 4h exerted the strongest docking binding value against the active sites of 6LU7. In addition, the synthesized compounds had a moderate to good free radical scavenging activity.
Timely sown maize hybrids improve the post-anthesis dry matter accumulation, nutrient acquisition and crop productivity
Authors: Zhiipao R. R. , Pooniya Vijay , Biswakarma Niraj , Kumar Dinesh , Shivay Y. S. , Dass Anchal , Mukri Ganapati , Lakhena K. K. , Pandey R. K. , Bhatia Arti , Govindasamy Prabhu , Burman Anamika , Babu Subhash , Jat R. D. , Dhaka A. K. , Swarnalakshmi Karivaradharajan 
Published: January 2023

AbstractDelayed sowing of maize hybrids could exacerbate the capability of maximizing the yield potential through poor crop stand, root proliferation, nutrient uptake, and dry matter accumulation coupled with the inadequate partitioning of the assimilates. This study appraised the performance of five recent maize hybrids viz., PMH-1, PJHM-1, AH-4158, AH-4271, and AH-8181 under timely and late sown conditions of the irrigated semi-arid ecologies. Timely sowing had the grain and stover yields advantage of 16–19% and 12–25%, respectively over the late sown maize hybrids. The advanced hybrids AH-4271 and AH-4158 had higher grain yields than the others. During the post-anthesis period, a greater dry matter accumulation and contribution to the grain yield to the tune of 16% and 10.2%, respectively, was observed under timely sown conditions. Furthermore, the nutrient acquisition and use efficiencies also improved under the timely sown. The nutrient and dry matter remobilization varied among the hybrids with AH-4271 and PMH-1 registering greater values. The grain yield stability index (0.85) was highest with AH-4158 apart from the least yield reduction (15.2%) and stress susceptibility index (0.81), while the maximum geometric mean productivity was recorded with the AH-4271 (5.46 Mg ha−1). The hybrids AH-4271 and PJHM-1 exhibited improved root morphological traits, such as root length, biomass, root length density, root volume at the V5 stage (20 days after sowing, DAS) and 50% flowering (53 DAS). It is thus evident that the timely sowing and appropriate hybrids based on stress tolerance indices resulted in greater yields and better utilization of resources.
Synthesis, characterization, and biodegradation studies of new cellulose-based polymers
Authors: Tabaght F. E. , Azzaoui K. , Idrissi A. El , Jodeh S. , Khalaf B. , Rhazi L. , Bellaouchi R. , Asehraou A. , Hammouti B. , Sabbahi R. 
Published: January 2023

AbstractNew cellulose carbamates and cellulose acetate carbamates were prepared by classical addition reaction of isocyanates with alcohols. A Telomerization technique was used to make the grafted molecules strongly anchored and more hydrophobic. These molecules were grafted into cellulose and CA chains, respectively. The structures of the synthesized derivatives were confirmed using Nuclear Magnetic Resonance Spectroscopy, Fourier Transform Infrared and Thermogravimetric Analysis, and their solubility phenomenon was also established, and the carbamate derivatives showed better solubility compared to cellulose. Their ability to biodegrade was investigated, and it was concluded that Cell-P1 and CA-P1 derivatives are more biodegradable than the other samples. These results suggest that the resulting compounds can be used effectively in many useful industrial fields, for instance, eco-friendly food packaging, domains that use materials that are environmentally friendly and sustainable and the development of green chemistry.
Studying the effect of self-selected background music on reading task with eye movements
Authors: Que Ying , Zheng Yueyuan , Hsiao Janet H. , Hu Xiao 
Published: January 2023

AbstractUsing background music (BGM) during learning is a common behavior, yet whether BGM can facilitate or hinder learning remains inconclusive and the underlying mechanism is largely an open question. This study aims to elucidate the effect of self-selected BGM on reading task for learners with different characteristics. Particularly, learners’ reading task performance, metacognition, and eye movements were examined, in relation to their personal traits including language proficiency, working memory capacity, music experience and personality. Data were collected from a between-subject experiment with 100 non-native English speakers who were randomly assigned into two groups. Those in the experimental group read English passages with music of their own choice played in the background, while those in the control group performed the same task in silence. Results showed no salient differences on passage comprehension accuracy or metacognition between the two groups. Comparisons on fine-grained eye movement measures reveal that BGM imposed heavier cognitive load on post-lexical processes but not on lexical processes. It was also revealed that students with higher English proficiency level or more frequent BGM usage in daily self-learning/reading experienced less cognitive load when reading with their BGM, whereas students with higher working memory capacity (WMC) invested more mental effort than those with lower WMC in the BGM condition. These findings further scientific understanding of how BGM interacts with cognitive tasks in the foreground, and provide practical guidance for learners and learning environment designers on making the most of BGM for instruction and learning.
Age-dependent thrombin generation predicts 30-day mortality and symptomatic thromboembolism after multiple trauma
Authors: Lesbo Maj , Hviid Claus V. B. , Brink Ole , Juul Svend , Borris Lars C. , Hvas Anne-Mette 
Published: January 2023

AbstractTrauma-induced coagulopathy (TIC) is a risk factor for death and is associated with deviations in thrombin generation. TIC prevalence and thrombin levels increase with age. We assayed in vivo and ex vivo thrombin generation in injured patients (n = 418) to specifically investigate how age impacts thrombin generation in trauma and to address the prognostic ability of thrombin generation. Biomarkers of thrombin generation were elevated in young (< 40 years) and older (≥ 40 years) trauma patients. In vivo thrombin generation was associated with Injury Severity Score (ISS) and this association was stronger in young than older patients. In vivo thrombin generation decreased faster after trauma in the young than the older patients. Across age groups, in vivo thrombin generation separated patients dying/surviving within 30 days at a level comparable to the ISS score (AUC 0.80 vs. 0.82, p > 0.76). In vivo and ex vivo thrombin generation also predicted development of thromboembolic events within the first 30 days after the trauma (AUC 0.70–0.84). In conclusion, younger trauma patients mount a stronger and more dynamic in vivo thrombin response than older patients. Across age groups, in vivo thrombin generation has a strong ability to predict death and/or thromboembolic events 30 days after injury.
Annual changes in grip strength and skeletal muscle mass in chronic liver disease: observational study
Authors: Endo Kei , Kakisaka Keisuke , Kuroda Hidekatsu , Miyasaka Akio , Takikawa Yasuhiro , Matsumoto Takayuki 
Published: January 2023

AbstractSarcopenia is a common complication in patients with chronic liver disease (CLD); however, the progression of sarcopenia over the course of CLD is unclear. The present study therefore determined the natural course of the progression of sarcopenia in patients with CLD and the effect of liver cirrhosis (LC) on this progression. This observational study analyzed patients with chronic hepatitis (CH) (n = 536) and LC (n = 320) who underwent evaluations of the grip strength and skeletal muscle mass of the arms, trunk, and legs for sarcopenia between 2016 and 2021. A bioelectrical impedance analysis was used to evaluate skeletal muscle mass. The annual rate of change (%/year) in two tests were compared between patients with CH and LC. The annual rates of change in grip strength and skeletal muscle of arms, trunk, and legs of patients with CH and LC were − 0.84% vs. − 2.93%, − 0.54% vs. − 1.71%, − 0.43% vs. − 1.02%, and − 0.76% vs. − 1.70% for men and − 0.12% vs. − 1.71%, − 0.66% vs. − 1.71%, − 0.49% vs. − 1.31%, and − 0.76% vs. − 1.54% for women, respectively. The progression of sarcopenia was greater in LC patients than in CH patients and that the decrease in grip strength was most prominent in the progression of sarcopenia in patients with LC.
Gamma irradiation mediated production improvement of some myco-fabricated nanoparticles and exploring their wound healing, anti-inflammatory and acetylcholinesterase inhibitory potentials
Authors: El-Sayed El-Sayed R. , Mansour Doaa S. , Morsi Reham M. , Elmonem Hanan A. Abd 
Published: January 2023

AbstractIn the current scenario, scaling up the microbial production of nanoparticles with diverse biological applications is an emerging prospect for NPs’ sustainable industry. Thus, this paper was conducted to develop a suitable applicative process for the myco-fabrication of cobalt-ferrite (CoFeNPs), selenium (SeNPs), and zinc oxide (ZnONPs) nanoparticles. A strain improvement program using gamma irradiation mutagenesis was applied to improve the NPs-producing ability of the fungal strains. The achieved yields of CoFeNPs, SeNPs, and ZnONPs were intensified by a 14.47, 7.85, and 22.25-fold increase from the initial yield following gamma irradiation and isolation of stable mutant strains. The myco-fabricated CoFeNPs, SeNPs, and ZnONPs were then exploited to study their wound healing, and anti-inflammatory. In addition, the acetylcholinesterase inhibition activities of the myco-fabricated NPs were evaluated and analyzed by molecular docking. The obtained results confirmed the promising wound healing, anti-inflammatory, and acetylcholinesterase inhibition potentials of the three types of NPs. Additionally, data from analyzing the interaction of NPs with acetylcholinesterase enzyme by molecular docking were in conformation with the experimental data.
Truncated ring-A amaryllidaceae alkaloid modulates the host cell integrated stress response, exhibiting antiviral activity to HSV-1 and SARSCoV-2
Authors: McNulty James , Babu-Dokuburra Chanti , Scattolon Jon , Zepeda-Velazquez Carlos , Wesesky Maribeth A. , Caldwell Jill K. , Zheng Wenxiao , Milosevic Jadranka , Kinchington Paul R. , Bloom David C. , Nimgaonkar Vishwajit L. , D’Aiuto Leonardo 
Published: January 2023

AbstractThe total synthesis of four novel mono-methoxy and hydroxyl substituted ring-A dihydronarciclasine derivatives enabled identification of the 7-hydroxyl derivative as a potent and selective antiviral agent targeting SARSCoV-2 and HSV-1. The concentration of this small molecule that inhibited HSV-1 infection by 50% (IC50), determined by using induced pluripotent stem cells (iPCS)-derived brain organ organoids generated from two iPCS lines, was estimated to be 0.504 µM and 0.209 µM. No significant reduction in organoid viability was observed at concentrations up to 50 mM. Genomic expression analyses revealed a significant effect on host-cell innate immunity, revealing activation of the integrated stress response via PERK kinase upregulation, phosphorylation of eukaryotic initiation factor 2α (eIF2α) and type I IFN, as factors potentiating multiple host-defense mechanisms against viral infection. Following infection of mouse eyes with HSV-1, treatment with the compound dramatically reduced HSV-1 shedding in vivo.
Experimental evaluation of the energy dissipation efficiency of the vortex flow section of drop shafts
Authors: Mahmoudi-Rad Mohammad , Najafzadeh Mohammad 
Published: January 2023

AbstractIn urban wastewater collection and drainage networks, vortex structures are recruited to transfer fluid between two conduits with significant level differences. During the drop shaft, in addition to preventing the fluid from falling due to vortex flow formation, a significant amount of the fluid energy is dissipated due to wall friction of vertical shaft. In the present study, by constructing a physical model with a scale of 1:10 made of Plexiglas, the energy dissipation efficiency in the vertical shaft has been investigated. In this way, the performance of dimensional analysis indicates that the flow Froude number (Fr) and the ratio of drop total height to shaft diameter (L⁄D) are parameters affecting the efficiency of flow energy dissipation in the vertical shaft (ηs). This research considers four levels of Fr factor (1.77, 2.01, 2.18, and 2.32) and three levels of L⁄D factor (10, 13, and 16). Additionally, four replications for 12 possible combinations allow us to carry out 48 experiments and the full factorial method. The results demonstrated that the energy dissipation efficiency in the vertical shaft changes varies from 10.80 to 62.29%. Moreover, ηs values decrease with an increase in Fr whereas the efficiency increases with increasing L⁄D ratio. Furthermore, the regression analysis gave a second-order polynomial equation which is a function of Fr and L⁄D to accurately estimate the flow energy dissipation efficiency in the vertical shaft.
Enhanced intelligent approach for determination of crude oil viscosity at reservoir conditions
Authors: Peiro Ahmady Langeroudy Kiana , Kharazi Esfahani Parsa , Khorsand Movaghar Mohammad Reza 
Published: January 2023

AbstractOil viscosity plays a prominent role in all areas of petroleum engineering, such as simulating reservoirs, predicting production rate, evaluating oil well performance, and even planning for thermal enhanced oil recovery (EOR) that involves fluid flow calculations. Experimental methods of determining oil viscosity, such as the rotational viscometer, are more accurate than other methods. The compositional method can also properly estimate oil viscosity. However, the composition of oil should be determined experimentally, which is costly and time-consuming. Therefore, the occasional inaccessibility of experimental data may make it inevitable to look for convenient methods for fast and accurate prediction of oil viscosity. Hence, in this study, the error in viscosity prediction has been minimized by taking into account the amount of dissolved gas in oil (solution gas–oil ratio: Rs) as a representative of oil composition along with other conventional black oil features including temperature, pressure, and API gravity by employing recently developed machine learning methods based on the gradient boosting decision tree (GBDT): extreme gradient boosting (XGBoost), CatBoost, and GradientBoosting. Moreover, the advantage of the proposed method lies in its independence to input viscosity data in each pressure region/stage. The results were then compared with well-known correlations and machine-learning methods employing the black oil approach applying least square support vector machine (LSSVM) and compositional approach implementing decision trees (DTs). XGBoost is offered as the best method with its greater precision and lower error. It provides an overall average absolute relative deviation (AARD) of 1.968% which has reduced the error of the compositional method by half and the black oil method (saturated region) by five times. This shows the proper viscosity prediction and corroborates the applied method's performance.
Repellent efficacy of 20 essential oils on Aedes aegypti mosquitoes and Ixodes scapularis ticks in contact-repellency assays
Authors: Luker Hailey A. , Salas Keyla R. , Esmaeili Delaram , Holguin F. Omar , Bendzus-Mendoza Harley , Hansen Immo A. 
Published: January 2023

AbstractCases of mosquito- and tick-borne diseases are rising worldwide. Repellent products can protect individual users from being infected by such diseases. In a previous study, we identified five essential oils that display long-distance mosquito repellency using a Y-tube olfactometer assay. In the current study, the contact repellent efficacy of 20 active ingredients from the Environmental Protection Agency’s (EPA) Minimum Risk Pesticides list were tested using Aedes aegypti and Ixodes scapularis. We utilized an arm-in-cage assay to measure complete protection time from mosquito bites for these active ingredients. To measure tick repellency, we used an EPA-recommended procedure to measure the complete protection time from tick crossings. We found that of the 20 ingredients tested, 10% v/v lotion emulsions with clove oil or cinnamon oil provided the longest protection from both mosquito bites and tick crossings. We conclude that in a 10% v/v emulsion, specific active ingredients from the EPA Minimum Risk Pesticides list can provide complete protection from mosquito bites and tick crossings for longer than one hour.
Analysis of dog breed diversity using a composite selection index
Authors: Hsu Wei-Tse , Williamson Peter , Khatkar Mehar Singh 
Published: January 2023

AbstractDuring breed development, domestic dogs have undergone genetic bottlenecks and sustained selective pressures, as a result distinctive genomic diversity occurs to varying degrees within and between breed groups. This diversity can be identified using standard methods or combinations of these methods. This study explored the application of a combined selection index, composite selection signals (CSS), derived from multiple methods to an existing genotype dataset from three breed groups developed in distinct regions of Asia: Qinghai-Tibet plateau dogs (adapted to living at altitude), Xi dogs (with superior running ability) and Mountain hounds (used for hunting ability). The CSS analysis confirmed top ranked genomic regions on CFA10 and CFA21 in Qinghai-Tibet plateau dogs, CFA1 in Xi dogs and CFA5 in Mountain hounds. CSS analysis identified additional significant genomic regions in each group, defined by a total of 1,397, 1,475 and 1,675 significant SNPs in the Qinghai-Tibetan Plateau dogs, Xi dogs and Mountain hounds, respectively. Chitinase 3 Like 1 (CHI3L1) and Leucine Rich Repeat Containing G Protein-Coupled Receptor 6 (LGR6) genes were located in the top ranked region on CFA7 (0.02–1 Mb) in the Qinghai-Tibetan Plateau dogs. Both genes have been associated with hypoxia responses or altitude adaptation in humans. For the Xi dogs, the top ranked region on CFA25 contained the Transient Receptor Potential Cation Channel Subfamily C Member 4 (TRPC4) gene. This calcium channel is important for optimal muscle performance during exercise. The outstanding signals in the Mountain dogs were on CFA5 with 213 significant SNPs that spanned genes involved in cardiac development, sight and generation of biochemical energy. These findings support the use of the combined index approach for identifying novel regions of genome diversity in dogs. As with other methods, the results do not prove causal links between these regions and phenotypes, but they may assist in focusing future studies that seek to identify functional pathways that contribute to breed diversity.