bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiology specialists versus other specialty physicians in the quality of anticoagulant therapy management for nonvalvular atrial fibrillation (NVAF) patients: A retrospective observational study
Authors: Liu Puqing , Yuan Fang , Zhang Yi , Chen Jingwen 
Published: April 2023

Abstract
Objective: Nonvalvular atrial fibrillation (NVAF) patients are increasingly being admitted in hospital and distributed both in the cardiology department and other departments. The perception and experience on anticoagulant therapy of clinical physicians are related to the quality of anticoagulation in NVAF patients. Our study aimed to explore the difference of anticoagulation quality between cardiology specialists and other specialty physicians.
Methods: A retrospective investigation was conducted in a Chinese tertiary hospital to collect patients with NVAF who were classified in the cardiology specialists managed anticoagulation care group (CMAC) group or other specialty physicians’ managed anticoagulation care (OMAC) group according to admission departments. The primary outcomes included emergency visiting events, bleeding events and thrombotic events. The secondary outcomes were practice of thrombotic and bleeding risk assessment, qualified warfarin TTR, appropriate medication of DOACs, patients’ follow-up rate and doctors’ knowledge on anticoagulant therapy.
Results: A total of 687 NVAF patients were enrolled, including 216 warfarin patients, 342 patients on rivaroxaban and 129 dabigatran patients. Between CMAC group and OMAC group: there was no difference in baseline characters; anticoagulation related emergency visiting event occurred 2.7% vs 9.4% (p=0.038) in warfarin subgroup; bleeding events occurred 4.5% vs 14.2% (p=0.015) in warfarin subgroup and 0.8% vs 14.3% (p=0.007) in dabigatran subgroup; thrombotic events incidence was not different in each anticoagulant subgroup (p>0.05); assessment of thrombotic risk or bleeding risk in each anticoagulant subgroup was apparently different (p=0.000); qualified TTR rate in warfarin subgroup was 36.4% vs 21.6% (p=0.011); appropriateness of rivaroxaban dosage was 28.1% vs 18.7% (p=0.019), appropriateness of dabigatran dosage was 54.5% vs 36.5%, (p=0.040); for follow-up of anticoagulation clinics the warfarin subgroup was 62.7% vs 48.1% (p=0.031), rivaroxaban subgroup was 58.4% vs 45.7%(p=0.019) and dabigatran subgroup was 71.2% vs 37.1 (p=0.000).
Conclusion: The study identified that the anticoagulation quality for NVAF patients in the CMAC group is better than in the OMAC group. And compared with other specialty physicians, cardiology specialists are much more acquainted with anticoagulant therapy. It is necessary to establish a cardiology specialists integrated multidisciplinary team to carry out anticoagulation management for all NVAF inpatients, so as to improve the quality of anticoagulant therapy.
Effects of Different Soil Amendments on Soil Physical and Chemical Properties, Rice Yield, and Economic Benefits in Low-lying Saline Alkali Land in Northern Shaanxi
Authors: Zhe Pang , Li Juan , Wang Qilong , Shen Jianglong 
Published: April 2023

Abstract
To explore the effects of different soil modifiers on the improvement of low-lying saline alkali land in Northern Shaanxi, the effects of three soil modifiers (desulfurization gypsum, “Jinfufeng” soil conditioner, and humic acid) on the physical and chemical properties soil, rice yield, and economic benefits were studied and compared through field experiment and indoor analysis. Results show that compared with the blank control, the three soil modifiers could effectively reduce the soil bulk density, improve the physical properties of soil, and reduce the soil pH, and humic acid could also significantly reduce the salt content of surface soil. In addition, the “Jinfufeng” soil conditioner and humic acid had a significant effect on the soil organic matter and total nitrogen contents but no significant effect on the available potassium and phosphorus. Desulfurized gypsum had a significant effect on the soil’s available potassium content but no significant effect on the organic matter and total nitrogen contents and the available phosphorus. The application of soil conditioner could significantly improve the 1000 grain weight and yield of rice, which respectively increased by 10.19–13.59% and 13.54–27.95% compared with the control. The 1000 grain weight and yield of the humic acid modifier treatment were the highest, reaching 23.4 g and 7380 kg•hm− 2, respectively. The analysis of economic benefits revealed that the application of a modifier could significantly improve the output value and net profit of rice. Among the modifiers, the application of a humic acid modifier could obtain the maximum output value, net profit, and yield investment ratio. Considering the rice quality, the rice yield, and the economic benefits, priority should be given to the application of a humic acid soil modifier to improve the low-lying saline alkali land in Northern Shaanxi.
Slit2-Robo4 Signal Pathway and Tight Junction in Intestine Mediate LPS-Induced Inflammation in Mice
Authors: Wang Lv , Chen Yingtai , Wu Hao , Qu Jin-long , Ma Linhao 
Published: April 2023

Abstract
Sepsis is one of the most common clinical diseases, which is characterized by a serious and uncontrollable inflammatory response. LPS-induced inflammation is a critical pathological event in sepsis, but the underlying mechanism has not yet been fully elucidated up to now. Here we reported that C57BL/6J mice injected with LPS (5 mg/kg, i.p.) for twenty-four hours could exhibit severe inflammatory reaction including an increased IL-1β, IL-18 in serum and activation of NLRP3 inflammasome in intestine. The injection of VX765 (10 mg/kg, i.p.), an inhibitor of NLRP3 inflammasome, could reverse these effects induced by LPS. The further experiment results of western blot and immunohistochemistry showed that Slit2 and Robo4 were significant decreased in intestine of LPS group, while the expression of VEGF was significant increased. Meanwhile, the protein level of tight junction protein ZO-1, occludin, and claudin-5 were significantly lower than in control group, which could also be reversed by VX765 injection. These results indicated that the increased level of IL-1β and IL-18 in serum induced by LPS is related to the increased intestinal permeability and activation of NLRP3 inflammasome. Altogether, our findings revealed that Slit2-Robo4 signaling pathway and tight junction in intestine may be involved in LPS-induced inflammation in mice, which may account for the molecular mechanism of sepsis.
Age and Maternal Mortality in Japan: Increased Maternal Mortality in Advanced Maternal Age
Authors: Tanaka Hiroaki , Hasegawa Junichi , Katsuragi Shinji , Tanaka Kayo , Arakaki Tatsuya , Nakamura Masamitsu , Hayata Eijiro , Nakata Masahiko , Murakoshi Takeshi , Sekizawa Akihiko , Ishiwata Isamu , Ikeda Tomoaki 
Published: April 2023

Abstract
Objectives: This study aimed to clarify the relationship between maternal mortality and advanced maternal age in Japan and to provide useful information for future perinatal management.
Methods: Maternal death rates by age group were investigated for all maternal deaths in Japan for an 11-year period, from 2010 to 2021. Maternal deaths among those aged ≥ 40 years were examined in detail to determine the cause of death, and the number of deaths by cause was calculated. The causes of onset of the most common causes of death were also investigated.
Results: The maternal mortality rates were 0.8 (95% confidence interval [CI], 0.3-4.7) for <20 years of age, 2.6 (95% CI, 1.7-3.8) for 20-24 years, 2.9 (95% CI, 2.3-3.6) for 25-29 years, 3.9 (95% CI, 3.3-4.5) for 30-34 years, 6.8 (95% CI, 5.9-7.9) for 35-39 years, and 11.2 (95% CI, 8.8-14.3) for ≥40 years. Patients who were ≥40 years of age had a significantly higher mortality rate compared to other age groups. Hemorrhagic stroke was the most common cause of death in patients aged ≥ 40 years (15/65 [23%]), and preeclampsia (8/15 [54 %]) was the most common cause of hemorrhagic stroke.
Conclusion: Maternal mortality is significantly higher in older pregnant women than in younger pregnant women in Japan, with hemorrhagic stroke being the most common cause of maternal death among women >40 years of age. More than half of hemorrhagic strokes are associated with gestational hypertensive nephropathy. These facts should be considered by women who become pregnant at an advanced age and by healthcare providers involved in their perinatal care.
Heparin Dose in Non-valvular Atrial Fibrillation Patients Undergoing Left Atrial Appendage Closure Under Different Antithrombotic Management
Authors: Liu Yan , Li HuaKang , Liu Feng , Wang XingPeng , Wei Xin , Wen Ling , Dong ShuYuan , Wan Chen , Xu Xiang , Zhang ZhiHui , Song ZhiYuan 
Published: April 2023

Abstract
Objective
To investigate the correlation between the heparin dose and activated clotting time (ACT) during left atrial appendage occlusion (LAAC) in patients with non-valvular atrial fibrillation (NVAF) under different antithrombotic management backgrounds and to provide evidence for the rational use of heparin in LAAC.
Methods
Patients with NVAF who underwent LAAC in our hospital from February 2017 to March 2021 were evaluated. The patients were grouped according to the type of antithrombotic therapy they received before LAAC and the international normalised ratio (INR) into the following groups: patients on antiplatelet drugs, patients on non-vitamin K antagonist oral anticoagulants, patients with a warfarin INR < 1.8, and patients with a warfarin INR ≥ 1.8. The heparin doses were 100, 100, 100, and 80 U/kg, respectively. To measure ACT, venous blood samples were collected at 15 minutes after administering the drug.
Results
The study enrolled 435 patients, comprising 135, 155, 107, and 78 in the antiplatelet drug, non-vitamin K antagonist oral anticoagulant, warfarin INR < 1.8, and, warfarin INR ≥ 1.8 groups, respectively. At baseline, the proportion of patients with coronary heart disease was significantly lower in the warfarin INR < 1.8 group than in the other three groups (p < 0.01), while there were no significant differences in other parameters among the groups (p > 0.05). The heparin dose was significantly lower in the warfarin INR ≥ 1.8 group (80.25 ± 2.84 U/kg) than in the other three groups (p < 0.001). There was no significant difference in the ACT among the four groups (p > 0.05). LAAC was completed in all 435 patients without perioperative bleeding or thromboembolic complications.
Conclusions
For patients not taking warfarin or with an INR < 1.8 on warfarin before LAAC, it is reasonable to use heparin at a dose of 100 U/kg. It is safe and effective to reduce the heparin dose by 20% in patients with an INR ≥ 1.8.
Analysis on epidemiological characters and HIV care continuum of HIV-infected students: a retrospective cohort study in Shandong province, China
Authors: Yang Xingguang , Li Ling , Zhang Na , Hao Lianzheng , Zhu Xiaoyan , Yu Haiying , Wang Guoyong , Kang Dianmin 
Published: April 2023

Abstract
Backgroud The proportion of HIV-infected students in China showed an increasing trend. This study aimed to identify the epidemiological characteristics and the status of HIV care continuum for HIV-infected students in Shandong Province, China.
Methods Case report data and follow-up data of HIV-infected students were obtained from the National HIV/AIDS comprehensive response information management system. Cochran-Armitage trend test was used to analyze the temporal trend of HIV-infected students over these years, Logistic regression analyses were used to analyze the influencing factors of HIV-infected students accepting CD4 + T cells (CD4) test and antiviral therapy (ART) in 30 days, and ArcGIS software was used for the spatial distribution map of student cases.
Results From 2017 to 2019, 403 HIV-infected students were reported in Shandong Province, 99.5% was male (401 cases) and 92.1% were homosexual transmitted. They distributed in 96 counties (96/139, 69.1%) of Shandong Province, mainly in Jinan city and Qingdao city. 99.3% (400 cases) received follow-up within 2 weeks, 99.0% (399 cases) acceptted CD4 test, 68.5% (276 cases) acceptted CD4 test in 30 days, 93.8% (378 cases) acceptted ART, and 48.6% (196 cases) started ART in 30 days. Binary Logistic regression analysis showed that the heterosexual transmitted cases (AOR = 0.458, 95%CI: 0.210–0.998), patients accepting HIV care in western Shandong (AOR = 0.266,95%CI: 0.147–0.481) were less likely to detecte CD4 within 30 days; patients aged 23–25 (AOR = 2.316, 95%CI: 1.009–5.316) and patients tested CD4 within 30 days (AOR = 4.377; 95%CI: 2.572–7.447) prefered to receive ART within 30 days; patients accepted HIV care in Central Shandong (AOR = 0.407; 95%CI: 0.251–0.657) and Western Shandong (AOR = 0.508; 95%CI: 0.261–0.989) and patients diagnosed by voluntary blood donation (AOR = 0.352; 95%CI: 0.144–0.864) were less willing to receive ART in 30 days.
Conclusions The HIV care continuum of HIV-infected students in Shandong Province still needed strenghthing. More health education and case management should be done for cases transmitted through heterosexual behavior, accepted HIV care in central and western Shandong, and diagnosed by voluntary blood donation.
The livestock sector can overshoot planetary boundaries and threaten Paris Agreement
Authors: Li Chaohui , Wu Xudong , Pradhan Prajal , Liu Jingyu , Li Zhi , Chen Guoqian 
Published: April 2023

Abstract
The livestock sector represents major challenges to safeguarding environmental integrity. Therefore, we comprehensively analyze twelve environmental impacts of the livestock sector from 1995 to 2016 and project them until 2030. Our findings show livestock production impacts land resources, freshwater use, energy demand, climate change, nitrogen and phosphorus flows, and atmospheric aerosol loading. The livestock sector alone will likely exceed the planetary boundary of GHG emissions by 2030 and pose threats to other boundaries. Continuation of the current patterns of livestock production will also preclude limiting global warming well below 2°C, as the Paris Agreement aims. The impacts from the livestock sector are unevenly distributed worldwide, with spillover effects from developed to developing regions. Livestock footprints, i.e., environmental impacts of the livestock sector, are concentrated in emerging economies of Asia & the Pacific and South America. In contrast, per-capita livestock footprints are highest in developed economies such as the US and the EU. The livestock sector represents targeted opportunities for climate change mitigation and global environmental change. Adopting a less meat-based diet can reduce livestock footprints.
LncRNA SNHG1 promotes colorectal cancer cells invasion and migration by upregulating SERPINA3
Authors: Xiao Yu-Feng , Yang Huan , Gong Chun-Li , Chen Yang , Li Zhi-Bin , Shi Qiuyue , Liu Jiao , Gao Nannan , He Bing , Wang Chao , wu yu , Liao Qiushi , Bai Jianying 
Published: April 2023

Abstract
Colorectal cancer metastasis (CRC) is the main reason for patients’ death and remains a crucial clinical challenge. LncRNAs play kinds of important roles in the progression of CRC metastasis, but the implied mechanisms are still unclear. In our research, we studied the lncRNA small nucleolus host gene 1 (SNHG1) which was up-regulated in CRC tissues, and the high expression of lncRNA SNHG1 was correlated with poor prognosis of patients. Functionally, lncRNA SNHG1 acted as an oncogene and promoted CRC cells invasion and migration. Mechanistically, lncRNA SNHG1 mainly located in cell cytoplasm, in which it recruited heterogeneous nuclear ribonucleoprotein D (HNRNPD) and increased the mRNA stability of serpin family A member 3 (SERPINA3), and then subsequently upregulated SERPINA3 expression to facilitated CRC cells invasion and migration. Our finding demonstrated a different role of lncRNA SNHG1 in the cytoplasm and lncRNA SNHG1/HNRNPD-SERPINA3 might serve as a potential therapy for CRC.
Functional Connectivity and Disability in Multiple Sclerosis: a Cross-sectional Study
Authors: Scheffer Morgana , Esper Nathalia Bianchini , Soares Nayron Medeiros , Becker Jefferson , Almeida Rosa Maria Martins 
Published: April 2023

Abstract
Multiple Sclerosis (MS) is characterized by an inflammatory demyelinating disease that affects the Central Nervous System (CNS). This disease results in lesions in the white and gray matter of the brain network architecture and can play an important role in the clinical symptoms. The objective of this study was to verify the connectivity of brain networks through RSfMRI in two different groups of MS when compared to mild (n = 26) and moderate (n = 25) EDSS. The results showed statistically significant differences -*between the groups. The moderate EDSS showed increased rsFC in the Right Posterior Cingulate Cortex, Left and Right Precuneus, Left Superior Temporal Gyrus, and Left Middle Cingulate Cortex compared to mild EDSS. We suggest studies that examine the combination of structural and functional changes in disability in MS
LncRNA018392 promotes proliferation of Liaoning cashmere goat skin fibroblasts through up-regulation of CSF1R by binding to SPI1
Authors: Jin Mei , Lyu Suhe , Liu Xinyang , Cui Lixin , Fan Weiyu 
Published: April 2023

Abstract
The Liaoning cashmere goat has been confirmed as a valuable genetic resource breed that is prohibited from genetic outflow in China, and it achieves the highest single fleece production. Hair follicle development in the cashmere goat is regulated by melatonin and long non-coding RNAs (lnRNAs). However, the role played by lncRNAs in mediating melatonin-promoted cash-mere growth remains unclear. A novel lncRNA-lncRNA018392 with significant overexpression, which played a certain role in the melatonin-promoted proliferation of cashmere skin fibroblasts, was screened in previous research. The flow cytometry and CCK-8 results confirmed that the knockdown of lncRNA018392 reversed the effect of melatonin on cell proliferation, and the prolif-eration of cashmere skin fibroblasts was inhibited after the cells were interfered with the gene CSF1R near lncRNA018392. The dual-luciferase reporter assay further demonstrated that lncRNA018392 can positively regulate the promoter of CSF1R. Moreover, as indicated by the results of RNA-binding protein immunoprecipitation (RIP) and chromatin immunoprecipitation sequencing (ChIP-Seq), lncRNA018392 formed a complex with transcription factor SPI1, and CSF1R served as a downstream target gene regulated by SPI1. As revealed by the results of this study, melatonin-mediated novel lncRNA018392 accelerated the cell cycle, facilitated cell proliferation, and inhibited apoptosis by recruiting SPI1 to up-regulate the expression of nearby gene CSF1R. This study lays a theoretical basis for clarifying the molecular mechanism of cashmere growth and molecular breeding of cashmere goats.
Transition From Depression to Mental Health: Toward an Operationalization of Plasticity
Authors: Branchi Igor , Colli Claudia Delli , Chiarotti Flavia , Campolongo Patrizia , Giuliani Alessandro 
Published: April 2023

Abstract
Plasticity is the ability to modify brain and behavior and allows the transition from psychopathology to mental wellbeing. High plasticity has been associated to high susceptibility to contextual factors, e.g., living conditions, which ultimately drive plasticity outcome. Here, we exploited network analysis to show that plasticity – i.e., the susceptibility to modify depression score – can be assessed by measuring the symptom network connectivity: the weaker the connectivity, the higher the plasticity, resulting in a greater modification in mood symptoms. We analyzed the STAR*D dataset and proved that connectivity strength at baseline is weaker in responder compared to non-responder patients. Moreover, connectivity strength at baseline was inversely correlated with improvement in depression score (Pearson's r=-0.87) and susceptibility to change mood according to context (Pearson's r=-0.77). This operationalization of plasticity provides a mathematical tool to investigate and predict resilience, vulnerability and recovery, and to develop novel approaches for the prevention and treatment of depression.
A systematic review of clinical psychological guidance for perinatal mental health
Authors: O’Brien Jayne , Gregg Lynsey , Wittkowski Anja 
Published: April 2023

Abstract
Background
Guidelines on psychological and/or psychosocial assessment and intervention in the perinatal period can provide beneficial practice guidance for healthcare professions to reduce maternal distress and potential mortality. As little is known about the similarities in recommendations across guidelines, which could impact the quality of therapeutic intervention women receive, this systematic review was conducted to draw out the consistent guidance for perinatal psychological and/or psychosocial therapeutic input.
Method
Eight literature and two guideline databases were searched alongside guideline development institutions, and organisations of maternity or perinatal mental health care. All relevant guidance was searched for and extracted before guideline quality was assessed using the AGREE-II instrument. Included guidelines had a primary or secondary focus on psychological assessment and therapeutic intervention for perinatal mental health difficulties. Using a narrative synthesis approach, recommendation consistencies and inconsistencies were outlined.
Results
From the 92 records screened, seven guidelines met the inclusion criteria. Only two guidelines were rated high (> 80%) across all assessed domains, with the other guidelines scoring between poor and excellent across domains. Highest rated domains across all seven guidelines were clarity of presentation (75%) and scope and purpose (70%). Recommendations for structured psychological assessment and intervention were most commonly reported in the guidelines; however, the level of detail and depth of information varied across guidelines. Whilst assessment and intervention recommendations for mother-infant dyad and partners were considered, research into working therapeutically with these client groups in perinatal mental health services is only just emerging. Hence, guideline recommendations for working with the mother-infant dyad and partners were based on consensus of expert opinion.
Conclusion
Perinatal mental health guidelines were consistent in scope but showed considerable variability in quality and depth of recommendations, which could have implications for standards of clinical practice. However, there is still a need to improve the evidence underpinning recommendations in perinatal mental health guidelines to advance the implementation of psychological and/or psychosocial interventions. High quality interventions in the perinatal period could improve outcomes for women and their families.