bluuebunny/crossref_metadata_2025_split huggingface dataset:
Показники вегетативної дисфункції у спортсменів з ознаками перетренованості
Authors: Шевець Валентина 
Published: May 2023

Резюме. У статті розглянуто показники вегетативної дисфункції та особливості вегетативної регуляції серцевого ритму в спортсменів. Мета. Аналіз науково-методичної літератури, опитування, методи діагностики. Методи. Вивчення показників вегетативної дисфункції та особливостей вегетативної регуляції серця у спортсменів. Результати. В ході дослідження були обстежені висококваліфіковані легкоатлети з використанням методики варіабельності серцевого ритму (ВСР), ортостатичної та кліностатичної проб та опитувальник за Вейном. Було вивчено основні часові, спектральні та показники варіабельності серцевого ритму, а також встановлено переважаючий тип вегетативної регуляції серцевої діяльності. Вивчення особливостей варіабельності серцевого ритму дає змогу оцінити стан механізмів регуляції фізіологічних функцій в організмі людини, а також загальної активності регуляторних механізмів, нейрогуморальної регуляції серця, співвідношення між симпатичною та парасимпатичною ланками вегетативної нервової системи. Досить важливим є і те, що отримані дані про функціональний стан спортсмена в подальшому можна використовувати для оцінювання тренувального процесу спортсмена і шляхів його оптимізації.
Ключові слова: перетренованість, спортсмени-легкоатлети, вегетативна дисфункція, варіабельність серцевого ритму, нефункціональне перенапруження.
rentabilidad del private equity
Authors: Lamothe Fernández Prosper , García Argüelles Eduardo 
Published: May 2023

El PE (private equity) posee características únicas, que incluyen el tiempo y el tamaño irregulares de los flujos de caja. Ello hace que la medición de las rentabilidades no sea sencilla y pueda implicar problemas a la hora de comparar con otros activos. A medida que el mercado madura, las formas de cálculo más sofisticadas podrían convertirse en estándar.
El mercado de PE se caracteriza por una amplia volatilidad de retornos en lo que se refiere a gestoras y fondos. Por ello, sería crucial realizar una buena selección con el fin de maximizar el diferencial frente a los mercados cotizados.
On the Love of All and None
Authors: McCaffrey Jaime , Levander Tore 
Published: May 2023

Nietzsche’s Zarathustra–a book for all and none–champions a love of the world and an embrace of life. Zarathustra’s embrace of life and eternal becoming is, in German, Lust: taking pleasure in all that becomes–one’s own life and the entire world of existence–eternally. “...[Lust] wants the eternity of all things” (Z “Drunken Song” §11). It is an overflowing sort of love, too grand to be directed toward one person.
In his love of all humans, all things, Zarathustra remains unable to acknowledge this Other. In order to love the Other as an equal, Zarathustra would have to forego his love of everyone. The other presents the Abgrund that can only be crossed with a tightrope. A love of everything and everyone is equally a love of no one: no one but oneself, but one’s own world. It is life on a mountain peak.
In its wanting eternity, Lust has no room to accommodate an Other. Is it possible, then, for Zarathustra to love another as an equal? Is there an Other that can exist for Zarathustra at all–or in order to love everything and everyone, must he remain alone? Drawing from a number of specific sections in Zarathustra, we will explore the possibility of loving the Other as an equal, considering the risks and dangers that a mutual love between Zararthustra and an Other might entail. Equal love–sharing in becoming–means relinquishing the solidity of one’s ground in order to experience the Other’s world.
Pengaruh Model Problem Based Learning Terhadap Kemampuan Berpikir Kritis Pada Materi Ekologi
Authors: Ridwan Yusuf Iwan , Salsabila Shahnaz 
Published: May 2023

Pendidikan yang sesuai dengan perkebangan perlu adanya perubahan dan inovasi salah satunya perubahan kurikulum menjasi kurikulum 2013. Pembelajaran sesuai dengan perkembangan zaman terhadap pengetahuan dan teknologi, model pembelajaran perlu dikembangkan. Perkembangan zaman pada pendidikan peserta didik sudah perlu untuk melatih berpikir secara kritis. Namun, saat dilapangan peserta didik masih kurang melatih kemampuan berpikir kritis. Dilaksanakan penelitian ini diharapkan peserta didik mampu melatih kemampuan berpikir kritis dengan bantuan model Pembelajaran Prolem Based Learning terhadap materi ekologi. Metode yang digunakan dalam penelitian ini yaitu pre-eksperimental menggunakan one group pretest-posttest design. Data yang diperoleh dianalisis dengan menggunakan Effect Size. Berdasarkan hasil penelitian diperoleh nilai rata-rata pretest sebelum menggunakan model pembelajaran Problem Based learning sebesar 56,07 dan nilai rata-rata posttest sebesar 70,71. Dari perhitunga Effect Size, dimana nilai Effect Size antara pretest dengan posttest yaitu 0,557 dengan kategori sedang, artinya terdapat efektivitas penerapan model pembelajaran Problem Based Learning terhadap berpikir kritis siswa materi Ekologi. Penelitian dilakukan terhadap peserta didik kelas VII-A di SMP Percontohan Laboratorium UPI Cibiru.
Assistência de enfermagem na promoção do autocuidado em pacientes portadores de ostomias intestinais
Authors: Silva Eliel Almeida da , Barros Esmeralda Emanuela Luna , Silva Fabio Ferreira da , Bezerra Nidia Carolina Marques , Santos Paula Renata de Melo 
Published: May 2023

Este estudo teve como objetivo identificar as evidências trazidas por estudos sobre a assistência de enfermagem ao paciente portador de ostomias intestinais. Revisão integrativa da literatura em que foram realizadas buscas nos bancos de dados LILACS, SciELO, BDENF, considerando como critérios de inclusão artigos divulgados em idioma português, a partir do ano de 2017. Foram excluídas pesquisas que não respondessem à questão norteadora. Foram selecionados 10 artigos, sendo todas as publicações de origem brasileira. A análise permitiu identificar três eixos temáticos, quais sejam: educação em saúde para os pacientes ostomizados durante assistência de enfermagem, principais dificuldades encontradas por pacientes para a realização do autocuidado, a importância do papel familiar e dos direitos assegurados. A educação em saúde, promovida pela equipe de enfermagem é de fundamental importância para adaptação, domínio e habilidades no desenvolvimento do autocuidado. Salienta-se que as condutas e orientações de enfermagem podem melhorar a compreensão e aceitação dessa nova condição de vida entre os ostomizados, familiar e sociedade diminuindo assim as possíveis sequelas negativas que essa condição venha trazer.
Avaliação da influência do frênulo lingual posterior no aleitamento materno: ensaio clínico
Authors: Alves Dayanne Oliveira , Guerra Cândida Augusta Rêbelo de Moraes , Sabino Maria de Fátima Pessoa de Araújo , Kozmhinsky Verônica Maria da Rocha , Alencar Thais Costa de , Veras Gabriella Aguiar Rodrigues 
Published: May 2023

Objetivo: Avaliar a influência do frênulo lingual posterior no aleitamento materno de bebês. Método: Tratar-se de um estudo longitudinal, de abordagem quali-quantitativa, descritiva e analítica do tipo ensaio clínico com fonte de dados primários. A população estudada foi composta pelas díades mãe-bebê saudáveis, de ambos os sexos, assistidos no Centro de Especialidades Odontológicas do Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, durante o período de setembro a novembro de 2022. A coleta de dados ocorreu a partir da avaliação do frênulo lingual dos bebês, bem como de entrevista com as mães. Os bebês foram divididos em dois grupos para fins comparativos, sendo eles o grupo de bebês de frênulo lingual posterior tipo III de Coryllos (GIII) e o grupo de bebês de frênulo lingual posterior tipo IV de Coryllos (GIV). Resultados: O frênulo posterior tipo III de Coryllos foi encontrado em 65,2% dos bebês, enquanto o tipo IV, em 34,8%. Desses, 56,5% estavam em amamentação exclusiva na primeira consulta e na segunda consulta houve um aumento para 73,9%. A prevalência das mães que receberam orientações sobre a importância do aleitamento materno durante a gestação foi 52,2%. Conclusão: Ambos os grupos de bebês com frênulo lingual posterior (GIII e GIV) apresentaram dificuldades no aleitamento, sendo mais prevalentes a dificuldade de pega e dor mamária durante a amamentação. Após a consulta inicial, diante da exposição a orientações, bem como ao procedimento cirúrgico da frenotomia lingual, houve melhora no quadro geral do aleitamento em quase totalidade dos casos.
SYNTHESIS AND PHOTOELECTROCHEMICAL PROPERTIES OF SU2O-CU3VO4 COMPOSITE FILMS
Authors: Smilyk Vitaliy , Fomaniyk Sergii , Kolbasov Gennady , Rysetskiy Igor , Danilov Michael 
Published: May 2023

Cu2O-Cu3VO4 films were obtained by elect­rochemical synthesis. The analysis of polarization curves and Pourbaix diagrams for copper and vanadium ions made it possible to analyze the possible reactions that occur during the deposition of films. At potentials from 0 to -0.2V, mainly monovalent copper oxide Cu2O with Cu3VO4 impurities precipitated in the working solution. At the same time, there are two competing processes of acidification of the near-electrode layer as a result Cu2O formation reaction and alkalinization as a result of the chemical interaction of Cu2O with HVO42-. The formation of an excess of OH- ions can inhibit the reaction rate of the formation of Cu3VO4, accelerating the reaction of the formation of Cu2O. Thus, deposition of Cu3VO4 will take place to a lesser extent compared to Cu2O. Accordingly, to increase the yield of Cu3VO4, an attempt was made to reduce the deposition current, which, according to literature, helps to reduce the effect of the pH change near the electrode layer. Where, as known the critical current limit at change pH starts from 5 or more mA/cm2. For the synthesis of the films, a current of up to 1 mA/cm2 selected, which contributed to the production of the Cu3VO4 - Cu2O composite, as was established further from the analysis of X-ray patterns. It is shown that their photoelectrochemical pro­perties depend on the heat treatment conditions. This is expressed by the difference in the spectral characteristics of the quantum yield and the value of the photocurrent in the samp­les annealed in air and argon. Using the X-ray phase analysis method, it was established that heat treatment in argon contributes to the formation of a Cu3VO4 and Cu2O composite, in contrast to heat treatment in air, where a mixture of CuO and V2O5 oxides is mainly formed. In the film annealed in air due to impact of wide-band oxide compounds, a smaller value of the quantum yield of the photoelectrochemical current and a narrower spectral dependence were observed. The stretching of the spectrum into the region of visible light on the spectral curves of the photocurrent quantum yield is caused by the contribution of copper vanadate with Eg = 1.5 eV. Analysis of photo­current quantum output spectra and X-ray patterns showed that an increase in monovalent copper in the film structure contributes to the growth of photocurrent in the wavelength range of 450-600nm at a potential of -0.2 relative. h.s.e in 2 times. This indicates a positive effect of heat treatment in argon on increasing the efficiency of photocathodes based on a composite of Cu3VO4 and Cu2O for photoelectrochemical cells.
Evaluation of Traditional and Complementary Medicine Applications Used in the COVID-19 Pandemic
Authors: KISKAÇ Neşe , KATRAN Hamdiye Banu , KISKAÇ Muharrem 
Published: May 2023

Objective: Traditional and complementary medicine practices have been used to protect and treat physical and mental diseases in different cultures and beliefs from past to present. In this study, it was aimed to determine which of the traditional and complementary medicine applications was used and its effectiveness in the pandemic.
Methods: 979 people aged 18 and over (between 18 and 73) participated in the study. In the online survey, province, age, gender, occupation, education status, marital status, presence of children, presence of chronic diseases, COVID-19 diagnosis status, whether there is a COVID-19 vaccine, awareness of traditional and complementary medicine practices and nutritional and food supplements, utilization has been questioned.
Results: It was observed that no nutritional and food supplements used by the participants before and during the coronavirus pandemic did not reduce the frequency of being diagnosed with COVID-19.
Conclusions: In the study, it was observed that no food and nutritional supplement reduced the frequency of receiving COVID-19. However, in order to evaluate the effectiveness of nutritional and food supplements, it was concluded that the sample of the participants should be equal in terms of occupation, age, whether they were infected or not, and that it should be supported by researches by questioning whether the patients diagnosed with COVID-19 had mild symptoms or not.
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis
Authors: Alsaikhan Fahad , Mahmoud Mustafa Z. , Suliman Muath 
Published: May 2023

Introduction: The metal-organic frameworks (MOF) have shown fascinating possibilities in biomedical applications, and designing a drug delivery system (DDS) based on the MOF is important. This work aimed at developing a suitable DDS based on Denosumab-loaded Metal Organic Framework/Magnesium (DSB@MOF (Mg)) for attenuating osteoarthritis.Materials and Methods: The MOF (Mg) (Mg3(BPT)2(H2O)4) was synthesized using a sonochemical protocol. The efficiency of MOF (Mg) as a DDS was evaluated by loading and releasing DSB as a drug. In addition, the performance of MOF (Mg) was evaluated by releasing Mg ions for bone formation. The MOF (Mg) and DSB@MOF (Mg) cytotoxicity towards the MG63 cells were explored by MTT assay.Results: MOF (Mg) characterized by using XRD, SEM, EDX, TGA, and BET. Drug loading, and releasing experiments proved that DSB was loaded on the MOF (Mg) and approximately 72% DSB was released from it after 8 h. The characterization techniques showed that MOF (Mg) was successfully synthesized with good crystal structure and thermal stability. The result of BET showed that MOF (Mg) had high surface areas and pore volume. This is the reason why its 25.73% DSB was loaded in the subsequent drug-loading experiment. Drug release and ion release experiments indicated DSB@MOF (Mg) had a good controlled release of DSB and Mg ions in solution. Cytotoxicity assay confirmed that the optimum dose of it had excellent biocompatibility and could stimulate the proliferation of MG63 cells as time went on.Conclusion: Due to the high loading amount of DSB and releasing time, DSB@MOF (Mg) can be promising as a suitable candidate for relieving bone pain caused by osteoporosis, with ossification-reinforcing functions.
The clinical implications of fasting serum insulin levels in patients with insulin-treated type 2 diabetes: a cross-sectional survey
Authors: Zhou Lingli , Luo Yingying , Wang Yan , Cheng Yao , Zhang Rui , Zhang Simin , Gong Siqian , Han Xueyao , Ji Linong 
Published: May 2023

ObjectiveThis study aimed to investigate the clinical implications of fasting serum insulin (FINS) levels in subjects with type 2 diabetes who were receiving insulin therapy.MethodsA total of 1,553 subjects with type 2 diabetes [774 subjects who had never received insulin treatment (N-INS) and 779 subjects who were receiving insulin therapy (constant insulin treatment, C-INS)] admitted to the Department of Endocrinology and Metabolism of Peking University People’s Hospital were enrolled in this study. Their FINS levels were measured and those with hyperinsulinemia were identified. The underlying mechanisms of hyperinsulinemia were revealed by measuring insulin antibodies (IAs) and analyzing changes in FINS levels before and after polyethylene glycol (PEG) precipitation. In addition, the clinical characteristics of patients with different types of hyperinsulinemia were compared.ResultsHigher FINS levels and a higher incidence (43.8%, 341/779) of hyperinsulinemia (FINS &gt; 15μIU/mL) were observed in subjects with C-INS than in subjects with N-INS. Among subjects with C-INS and hyperinsulinemia, 66.9% (228/341) were IAs positive, and the incidence of IAs was found to be positively associated with FINS level. By performing PEG precipitation, we found that all subjects without IAs (i.e., those with real hyperinsulinemia) and 31.1% of subjects (71/228) with IAs (i.e., those with both real and IAs-related hyperinsulinemia) still had hyperinsulinemia after PEG precipitation, whereas FINS levels in the other 68.9% of subjects (157/228) with IAs were normal (IAs-related hyperinsulinemia) after PEG precipitation. Comparisons between the groups showed that subjects with real hyperinsulinemia showed more obvious insulin resistance characteristics, including higher lipid levels, BMIs, and homoeostasis model assessment2-estimated insulin resistance (HOMA2-IR) index, and were more likely to have hypertension, obesity, and metabolic syndromes (p &lt; 0.05). However, the risk of hypoglycemia and glucose variability increased significantly in subjects with IAs compared with those without IAs. A cutoff of FINS to serum C-peptide ratio (≥ 9.3μIU/ng) could be used to screen IAs in clinical practice with 83.3% sensitivity and 70% specificity.ConclusionsIt is necessary to measure FINS in subjects with C-INS to distinguish between types of hyperinsulinemia, which should help to tailor treatment regimens.
Improving yields by switching central metal ions in porphyrazine-catalyzed oxidation of glucose into value-added organic acids with SnO2 in aqueous solution
Authors: Zhang Quanquan , Li Xin , Wang Xingwang , Huang Xin , Liu Yuncai , Wu Fengshou , Zhang Bingguang , Deng Kejian 
Published: May 2023

Photocatalysis has exhibited huge potential in selective conversion of glucose into value-added chemicals. Therefore, modulation of photocatalytic material for selective upgrading of glucose is significant. Here, we have investigated the insertion of different central metal ions, Fe, Co, Mn, and Zn, into porphyrazine loading with SnO2 for access to more efficient transformation of glucose into value-added organic acids in aqueous solution at mild reaction conditions. The best selectivity for organic acids containing glucaric acid, gluconic acid, and formic acid of 85.9% at 41.2% glucose conversion was attained by using the SnO2/CoPz composite after reacting for 3 h. The effects of central metal ions on surficial potential and related possible factors have been studied. Experimental results showed that the introduction of metalloporphyrazine with different central metal ions on the surface of SnO2 has a significant effect on the separation of photogenerated charges, changing the adsorption and desorption of glucose and products on the catalyst surface. The central metal ions of cobalt and iron contributed more to the positive effects toward enhancing conversion of glucose and yields of products, and manganese and zinc contributed more to the negative effects, resulting in the poor yield of products. The differences from the central metals may attribute to the surficial potential change of the composite and the coordination effects between the metal and oxygen atom. An appropriate surficial potential environment of the photocatalyst may achieve a better interactive relationship between the catalyst and reactant, while appropriate ability of producing active species matched with adsorption and desorption abilities would gain a better yield of products. These results have provided valued ideas for designing more efficient photocatalysts in selective oxidation of glucose utilizing clean solar energy in the future.
Ovarian juvenile granulosa cell tumors with Ollier’s disease in children with IDH1 gene somatic mutation
Authors: Zhang Jin , Hua Renwu , Ma Lishuang , Liu Chao , Zhang Yanxia , Lü Xuemin , Wang Tianren , Wan Naijun 
Published: May 2023

ObjectiveThe aim of this study was to explore the symptoms, treatment, and pathogenesis of ovarian juvenile granulosa cell tumors with Ollier’s disease in children.MethodsFrom October 2019 to October 2020, clinical data were retrospectively analyzed for one case of ovarian juvenile granulosa cell tumors with Ollier’s disease. Whole-exome sequencing and Sanger sequencing were used to detect gene mutation in ovarian tumor and chondroma tissue. NADP-dependent isocitrate dehydrogenase-1 (IDH1) and S6 ribosomal protein expression levels in cells transfected with wild-type or mutant plasmid were analyzed by Western blot.ResultsThe 4-year-old female showed multiple skeletal deformities, bilateral breast development with chromatosis, and vulvar discharge. Sex hormone assay suggested that estradiol and prolactin were elevated, and the x-ray of limbs suggested enchondroma. Pelvic ultrasound and abdominal CT revealed a right ovarian solid mass. Pathologic examination of the right ovarian solid mass showed a juvenile granulosa cell type. A c.394C&gt;T (p. Arg132Cys) mutation of the IDH1 gene was detected in both the ovarian juvenile granulosa cell tumors and enchondroma. Transfection of HeLa cells with either WT or Mut plasmid caused 4.46- or 3.77-fold overexpression of IDH1 gene compared to non-transfected control cells, respectively. R132C mutation inhibited the phosphorylation of S6 ribosomal protein, which is central to the mTOR pathway. Postoperatively, estradiol and prolactin levels fell to values normal for her age and bilateral breast gradual retraction.ConclusionThe incidence of ovarian juvenile granulosa cell tumors with Ollier’s disease in children may be caused by generalized mesodermal dysplasia; IDH1 gene mutation may play a facilitated role in this process. Surgical operation is the main treatment. We suggest that patients with ovarian juvenile granulosa cell tumors and Ollier’s disease should undergo regular investigation.
Association of solute carrier family 30 A8 zinc transporter gene variations with gestational diabetes mellitus risk in a Chinese population
Authors: Zeng Qiaoli , Tan Bing , Han Fengqiong , Huang Xiujuan , Huang Jinzhi , Wei Yue , Guo Runmin 
Published: May 2023

BackgroundThe solute carrier family 30 A8 zinc transporter (SLC30A8) plays a crucial role in insulin secretion. This study aimed to investigate the impact of SLC30A8 gene polymorphisms on gestational diabetes mellitus (GDM).MethodsThe research objective was to select 500 patients with GDM and 502 control subjects. Rs13266634 and rs2466293 were genotyped using the SNPscan™ genotyping assay. Statistical tests, such as the chi-square test, t-test, logistic regression, ANOVA, and meta-analysis, were conducted to determine the differences in genotypes, alleles, and their associations with GDM risk.ResultsStatistically significant differences were observed in age, pregestational BMI, SBP, DBP, and parity between individuals with GDM and healthy subjects (P &lt; 0.05). After adjusting for these factors, rs2466293 remained significantly associated with an increased risk of GDM in overall subjects (GG+AG vs. AA: OR = 1.310; 95% CI: 1.005-1.707; P = 0.046, GG vs. AA: OR = 1.523; 95% CI: 1.010-2.298; P = 0.045 and G vs. A: OR = 1.249; 95% CI: 1.029-1.516; P = 0.024). Rs13266634 was still found to be significantly associated with a decreased risk of GDM in individuals aged ≥ 30 years (TT vs. CT+CC: OR = 0.615; 95% CI: 0.392-0.966; P = 0.035, TT vs. CC: OR = 0.503; 95% CI: 0.294-0.861; P = 0.012 and T vs. C: OR =0.723; 95% CI: 0.557-0.937; P = 0.014). Additionally, the haplotype CG was found to be associated with a higher risk of GDM (P &lt; 0.05). Furthermore, pregnant women with the CC or CT genotype of rs13266634 exhibited significantly higher mean blood glucose levels than those with the TT genotype (P &lt; 0.05). Our findings were further validated by the results of a meta-analysis.ConclusionThe SLC30A8 rs2466293 polymorphism was found to be associated with an increased risk of GDM, while rs13266634 was associated with a decreased risk of GDM in individuals aged ≥ 30 years. These findings provide a theoretical basis for GDM testing.