bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in recurrence analysis of dynamical systems
Authors: Marwan Norbert , Kraemer K. Hauke 
Published: January 2023

AbstractThe last decade has witnessed a number of important and exciting developments that had been achieved for improving recurrence plot-based data analysis and to widen its application potential. We will give a brief overview about important and innovative developments, such as computational improvements, alternative recurrence definitions (event-like, multiscale, heterogeneous, and spatio-temporal recurrences) and ideas for parameter selection, theoretical considerations of recurrence quantification measures, new recurrence quantifiers (e.g. for transition detection and causality detection), and correction schemes. New perspectives have recently been opened by combining recurrence plots with machine learning. We finally show open questions and perspectives for futures directions of methodical research.
Statins and Cancer Prevention—Association Does Not Mean Causation
Authors: Das Sanjay , Freedland Stephen J. 
Published: January 2023

Statins are widely prescribed medications that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase and therefore reduce cholesterol synthesis. Given the key role of cholesterol in cancer, statins may therefore have anticancer activities. However, clinical studies investigating the association between statin usage and cancer development have been few and inconsistent. A recent study from Maeda-Minami and colleagues found a significant, though modest, decrease in cancer risk among statin users. However, does this finding mean statin usage directly reduces cancer risk or is merely associated with reduced cancer risk? This editorial analyzes Maeda-Minami and colleagues’ study to provide commentary on statin's proposed role in preventing cancer.See related article, p. 37
Abstract IA003: Aspirin and cancer: what’s next?
Authors: Chan Andrew T 
Published: January 2023

Abstract
The remarkably consistent evidence demonstrating that aspirin is associated with a lower risk of colorectal cancer led to a first-if-its-kind U.S. Preventive Services Task Force (USPSTF) recommendation for population use of aspirin for cancer prevention. However, in 2022 the USPSTF reversed this recommendation based largely on data from the Aspirin to Prevent Events in the Elderly randomized trial of aspirin in older adults. Surprisingly, the ASPREE trial showed that aspirin increased the risk of cancer-related death after 4.7 years of follow-up. These results suggest the intriguing possibility that aspirin may have a differential effect on cancer risk according to age and highlights the limitation of a “one-size-fits-all” approach to aspirin prevention. To date, the paradigm of “precision medicine,” the use of molecular biomarkers to optimize treatment response that has revolutionized cancer care has not been readily translated to cancer prevention. This situation is largely due to knowledge gaps regarding the biological mode-of-action of most preventive agents. In this presentation, Dr. Chan will discuss opportunities for developing precision prevention approaches for promising agents such as aspirin for future clinical translation.
Citation Format: Andrew T Chan. Aspirin and cancer: what’s next? [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr IA003.
Abstract P005: SLC38A5 characterization and its tumor promoting role in pancreatic ductal adenocarcinoma
Authors: Sniegowski Tyler J. , Ganapathy Vadivel , Bhutia Yangzom 
Published: January 2023

Abstract
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal and aggressive cancers. Based on the Human Protein Atlas database, solute carrier 38A5 (SLC38A5) is significantly upregulated in PDAC and correlates with poor patient survival. SLC38A5 is a Na+-coupled, electroneutral amino acid transporter that transports glutamine, serine, glycine, and methionine that are essential for glutaminolysis and one-carbon metabolism pathways on which cancer cells are dependent. Furthermore, SLC38A5 is a c-Myc target and induces macropinocytosis. Thus, these attributes of SLC38A5 in cancer cells makes it a favorable contribution to their tumor-promoting gene expression programs. Using real-time PCR and Western blotting, we validated the expression status of SLC38A5 in PDAC cell lines, patient derived xenografts (PDX), and organoids. Using radiolabeled serine uptake, we also confirmed that PDAC cell lines express functional SLC38A5. To investigate the tumor promoting role of SLC38A5, shRNA-mediated knockdown of SLC38A5 was performed in BxPC-3 and HPAF-II human PDAC cell lines. After validating SLC38A5 knockdown using real-time PCR and radiolabeled serine uptake, colony formation and transwell invasion assay were performed using the knockdown cells and non-targeting controls (NTC). Interestingly, SLC38A5 knockdown suppressed the colony formation ability as well as the invasion capacity in both cell lines, suggesting the tumor promoting role of SLC38A5. To extrapolate the in vitro data further, we performed subcutaneous xenograft using SLC38A5-silenced BxPC-3 and HPAF-II cells into the athymic nude mice. Interestingly, we found that SLC38A5 knockdown cells grew slower, as evidenced by smaller tumor weight, further validating our in vitro data. Our future work involves extrapolating these data in the KPC (Kras, p53, and PDX-1-Cre) spontaneous mouse model of PDAC and elucidating its mechanism of upregulation.
Citation Format: Tyler J. Sniegowski, Vadivel Ganapathy1, Yangzom Bhutia. SLC38A5 characterization and its tumor promoting role in pancreatic ductal adenocarcinoma. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr P005.
Abstract PR003: Multiplexed immune phenotyping and miRNA-ISH in bronchial premalignant lesions reveals a mechanism of immune suppression
Authors: Chiu Darren J. , Pfefferkorn Roxana , Green Emily , Ning Boting , Constant Myrtha , Lenburg Marc , Burks Eric , Mazzilli Sarah , Beane Jennifer 
Published: January 2023

Abstract
Bronchial premalignant lesions (PMLs) are precursors of lung squamous cell carcinoma. Prior work has shown that among proliferative subtype PMLs, progression to or persistence of a high-grade histology is associated with downregulation of an immune-related gene module. Furthermore, microRNA-149 (miR-149) was identified as a candidate negative regulator of this expression program. In this study, we aim to investigate the spatial distribution of miR-149 and its association with the immune environment and PML progression/persistence in PMLs. We identified 19 paraffin embedded bronchial biopsies transcriptionally defined as belonging to the proliferative subtype obtained from 9 subjects. Three consecutive sections were stained with H&E for histology annotation, chromogenic miRNA in situ hybridization (miRNA-ISH) for miR-149 abundance and localization, and with 30 antibodies targeted to epithelial and immune populations using imaging mass cytometry (IMC) to perform phenotyping. We trained a robust pixel classifier to detect foci of miR-149 signal in miRNA-ISH and quantified the density of miR-149 signal. For the IMC data, we used Mesmer for cell segmentation. PhenoGraph clustering based on quantification of each antibody in each cell was used for cell population identification. Ten recurrent cellular neighborhoods were identified by K-means clustering. miR-149 density was greater in the epithelium compared with stromal tissue. The miR-149 density in dysplastic epithelium normalized to miR-149 in normal epithelium is higher in the progressive/persistent PMLs than regressive PMLs. Additionally, in progressive/persistent PMLs, we find lower average epithelial staining for the miR-149 target NLRC5 associated with a cellular neighborhood that is enriched for goblet cells and PDL1+MUC5B+ secretory cells. Cell composition analysis showed that progressive/persistent PMLs have lower CD8 T cell infiltrate in both the stroma and epithelium. These results suggest that increased miR-149 expression in progressive/persistent PMLs contributes to an immune suppressive environment characterized by a shift in secretory cell populations and T cells within the bronchial epithelium. Interventions targeting miR-149 expression may be a potential interception strategy for high-grade PMLs.
Citation Format: Darren J. Chiu, Roxana Pfefferkorn, Emily Green, Boting Ning, Myrtha Constant, Marc Lenburg, Eric Burks, Sarah Mazzilli, Jennifer Beane. Multiplexed immune phenotyping and miRNA-ISH in bronchial premalignant lesions reveals a mechanism of immune suppression. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr PR003.
Genetic Effect on Body Mass Index and Cardiovascular Disease Across Generations
Authors: Sarnowski Chloé , Conomos Matthew P. , Vasan Ramachandran S. , Meigs James B. , Dupuis Josée , Liu Ching-Ti , Leong Aaron 
Published: January 2023

Background:
Whether genetics contribute to the rising prevalence of obesity or its cardiovascular consequences in today’s obesogenic environment remains unclear. We sought to determine whether the effects of a higher aggregate genetic burden of obesity risk on body mass index (BMI) or cardiovascular disease (CVD) differed by birth year.

Methods:
We split the FHS (Framingham Heart Study) into 4 equally sized birth cohorts (birth year before 1932, 1932 to 1946, 1947 to 1959, and after 1960). We modeled a genetic predisposition to obesity using an additive genetic risk score (GRS) of 941 BMI-associated variants and tested for GRS–birth year interaction on log-BMI (outcome) when participants were around 50 years old (N=7693). We repeated the analysis using a GRS of 109 BMI-associated variants that increased CVD risk factors (type 2 diabetes, blood pressure, total cholesterol, and high-density lipoprotein) in addition to BMI. We then evaluated whether the effects of the BMI GRSs on CVD risk differed by birth cohort when participants were around 60 years old (N=5493).

Results:

Compared with participants born before 1932 (mean age, 50.8 yrs [2.4]), those born after 1960 (mean age, 43.3 years [4.5]) had higher BMI (median, 25.4 [23.3–28.0] kg/m
2
versus 26.9 [interquartile range, 23.7–30.6] kg/m
2
). The effect of the 941-variant BMI GRS on BMI and CVD risk was stronger in people who were born in later years (GRS–birth year interaction:
P
=0.0007 and
P
=0.04 respectively).

Conclusions:
The significant GRS–birth year interactions indicate that common genetic variants have larger effects on middle-age BMI and CVD risk in people born more recently. These findings suggest that the increasingly obesogenic environment may amplify the impact of genetics on the risk of obesity and possibly its cardiovascular consequences.
Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis
Authors: Yonker Lael M. , Swank Zoe , Bartsch Yannic C. , Burns Madeleine D. , Kane Abigail , Boribong Brittany P. , Davis Jameson P. , Loiselle Maggie , Novak Tanya , Senussi Yasmeen , Cheng Chi-An , Burgess Eleanor , Edlow Andrea G. , Chou Janet , Dionne Audrey , Balaguru Duraisamy , Lahoud-Rahme Manuella , Arditi Moshe , Julg Boris , Randolph Adrienne G. , Alter Galit , Fasano Alessio , Walt David R. 
Published: January 2023

Background:
Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these individuals have not been described in detail.

Methods:
From January 2021 through February 2022, we prospectively collected blood from 16 patients who were hospitalized at Massachusetts General for Children or Boston Children’s Hospital for myocarditis, presenting with chest pain with elevated cardiac troponin T after SARS-CoV-2 vaccination. We performed extensive antibody profiling, including tests for SARS-CoV-2–specific humoral responses and assessment for autoantibodies or antibodies against the human-relevant virome, SARS-CoV-2–specific T-cell analysis, and cytokine and SARS-CoV-2 antigen profiling. Results were compared with those from 45 healthy, asymptomatic, age-matched vaccinated control subjects.

Results:

Extensive antibody profiling and T-cell responses in the individuals who developed postvaccine myocarditis were essentially indistinguishable from those of vaccinated control subjects, despite a modest increase in cytokine production. A notable finding was that markedly elevated levels of full-length spike protein (33.9±22.4 pg/mL), unbound by antibodies, were detected in the plasma of individuals with postvaccine myocarditis, whereas no free spike was detected in asymptomatic vaccinated control subjects (unpaired
t
test;
P
<0.0001).

Conclusions:
Immunoprofiling of vaccinated adolescents and young adults revealed that the mRNA vaccine–induced immune responses did not differ between individuals who developed myocarditis and individuals who did not. However, free spike antigen was detected in the blood of adolescents and young adults who developed post-mRNA vaccine myocarditis, advancing insight into its potential underlying cause.
Research, Representation, and Conservation of Mani Heaps: The Digitalization Projects
Authors: Peng Zhijun , Sun Han , Tao Wenyuan , Wang Haoyu , Kang Qibin , Xu Wenguang , Zeng Fanyue , Lin Chenzheng 
Published: January 2023

Abstract
A kind of cultural heritage, a Mani heap is piled with many carving stones and used as a religious altar for prayer in daily life in Tibet. It has distinctive characteristics and high research value, providing extensive content and abundant information. This paper focuses on an overview of three digitization projects for Mani heaps. Based on the collected data of five field surveys, the three projects leverage digitization methods to introduce, analyze, and represent Mani heaps to support scholarly analysis and casual appreciation. The authors explore these projects to study, represent, and conserve Mani heaps, which are often ignored by researchers.
‘Shaming’ the Court: Ukraine’s Constitutional Court and the Politics of Constitutional Law in the Post-Euromaidan Era
Authors: Nekoliak Andrii 
Published: January 2023

Abstract
Since the Euromaidan events of 2014, Ukraine has embarked on a reformist trajectory to ‘Europeanize’ the country and deliver the promise of good governance to its citizens. The series of legislative and public policy reforms that followed had financial and ideological support from Ukraine’s Western partners. To date, studies have focused on documenting and analyzing the course of international donors’ involvement in Ukraine’s reforms. What is lacking, however, is an analysis of the many different domestic responses to external pressure from donors to implement reforms. Examining Ukraine’s Constitutional Court case law on judicial self-government and anti-corruption from 2020, this article examines this court’s legal response to the politics of reform led by international donors and domestic actors in Ukraine. It reveals the problematic nature of constitutional decision-making in a country that has recently been facing considerable pressure from political incumbents and civil society. The article identifies a pattern that characterizes the political process (a ‘troubled nexus’) around the reforms in Ukraine and draws a parallel between Ukrainian developments and the situation in Moldova and Georgia, two countries that have been confronted with similar reform challenges since the enactment of the respective Association Agreements with the EU in 2016.
Charity for Christian Unity
Authors: Levant Marie 
Published: January 2023

Abstract
At the end of the First World War, a profoundly transformed Middle East faced massive population displacements and health crises, which presented crucial challenges for humanitarian actors. North American philanthropy and charity played a decisive role in this context. Among the organisations involved, the Catholic Near East Welfare Association (cnewa) is not well known. It was established by American Catholics to help Eastern Christians – especially Greek Catholics – and to thwart the influence of Protestantism in the region, mainly by supporting local Churches and missions in their humanitarian and welfare work. cnewa was quickly placed under the supervision of the US episcopate and the Vatican, partly transforming its operations and purposes. Its activity became closely involved with the Eastern policy of the Holy See, which primarily focused on the “return” of Orthodox Christians to the Roman Church. This article, at the crossroads of the history of mission and humanitarian aid, examines the early developments of cnewa and highlights how the Catholic Church dealt with the emergence of modern humanitarian aid in the mid-twentieth century.
Between Traditions of Aid and Political Ambitions: Endowments and Humanitarian Associations in Egypt, Late 19th-mid 20th Century
Authors: El-Neklawy Shaimaa Esmail , Möller Esther 
Published: January 2023

Abstract
The article investigates the emergence and transformation of humanitarian associations in Egypt from the late 19th to the mid-20th century. It argues that on the one hand these associations were new institutions echoing the foundation of new charitable organisations worldwide and in Egypt. The colonial domination of Egypt and its refusal by the Egyptians thereby played a prominent role. On the other hand, the humanitarian associations have to be seen in the continuity of long-established practices and discourses of charity, performed in particular by religious endowments (awqāf). Based on the example of the Egyptian Red Crescent, which is explored through a wide range of un explorer Egyptian, British and Swiss archives as well as a broad historiography in European and Arabic languages, this article emphasises the interconnections between international, regional, national and local institutions in Egypt in the field of philanthropy.
The effectiveness of a nurse-led health development programme on fourth-grade school-age children in North Cyprus: A randomised-controlled trial
Authors: Güler Rasiha , Kublay Gülümser , Fırat Kılıç Hülya 
Published: January 2023

Objective: This study sought to analyse the effectiveness of a nurse-led health development programme for school-aged children in North Cyprus. Design: This study utilised a randomised-controlled experimental research design. Setting: The study was conducted on fourth-grade students in two primary schools. Method: Participants in the intervention group received a 12-week online health education course. Students in both the control ( n = 38) and intervention ( n = 38) groups completed the Food Behaviour Scale, the Children Health Perceptions and Behaviours Scale, and the Physical Activity Self-Efficacy Scale pre-intervention, at the end of intervention and 3 months post-intervention. Results: Post-test scores for the intervention group on the Food Behaviour Scale, Children Health Perceptions and Behaviours Scale, and Physical Activity Self-Efficacy Scale were significantly higher than their pre-test scores. In contrast, the control group exhibited no statistically significant difference between the pre- and post-test scores on the three scales. Conclusion: The findings suggest that a nurse-led health education programme had a positive effect on food behaviour, physical activity self-efficacy, and health perception and behaviours among school-age children.
Mechanical properties of extruded continuous glass fiber reinforced wood Particle/HDPE composites: Effects of glass bundle tex and arrangement
Authors: Pourghayoumi Majid , Jamali Ali , Behravesh Amir Hossein , Mazdi Mohammad , Hedayati Seyyed Kaveh , Naeini Hassan Moslemi 
Published: January 2023

Mechanical properties considerably reduce in wood-plastic composites (WPCs) due to the use of wood particles, so the structural applications of these composites are scarce. Thus, embedding continuous fibers is considered the most reliable method for increasing mechanical properties, although there are still challenges in employing this method on a large scale. In this study, an elaborated, special modular die with the capability of adjusting 14 rovings of continuous fibers was designed, manufactured, and implemented to simultaneously embed continuous glass fibers into the extruded WPC profile. More precisely, it was aimed to investigate the arrangement of fiber rovings into the desired positions in a WPC profile of 70 wt% wood content. Also, the effect of the glass bundle tex (at three level, 1200,2400 and 4800) and the fiber position (at four levels, 0, 2, 4, and 6 mm of relative movement of the guides) on the mechanical properties of WPCs was evaluated. According to the results, the flexural strength of reinforced specimens for 1200, 2400, and 4800 texes increased by 85.8, 107, and 159.7%, respectively, compared with the non-reinforced composite. Theoretical values were calculated and compared with experimental outcomes. Based on the results, The failure mode was non-catastrophic, which means the specimens were able to carry partial loading; a desirable characteristic for the structural applications.
The ProtekDuo dual-lumen cannula for temporary acute mechanical circulatory support in right heart failure: A systematic review
Authors: Brewer Joseph M , Capoccia Massimo , Maybauer Dirk M , Lorusso Roberto , Swol Justyna , Maybauer Marc O 
Published: January 2023

Introduction Acute right ventricular failure (aRVF) is associated with high mortality and morbidity. Mechanical circulatory support (MCS) may be considered as an advanced treatment option. The ProtekDuo is a cannula that can be used to provide acute right ventricular support as part of a temporary percutaneous (tp) right ventricular assist device (RVAD) system. The primary objective of this systematic review is to describe patient survival and complications when the ProtekDuo cannula was used as part of an tpRVAD system. Methods MEDLINE, Embase, and Scopus were searched from database inception to August 26, 2022. Reference sections of studies were reviewed to screen for database omissions. Results Seven studies with 127 patients were eligible for inclusion. The studies included patients with aRVF from a variety of causes. Mean duration of support was between 10 and 58 days in five studies. Patient survival to discharge was between 60% and 85.2% in two studies. Four authors reported 30-day survival between 60% and 85.2%. Devicerelated and non-device related complications were low. Conclusions Patients treated with RVAD using the ProtekDuo cannula have comparable survival rates and complications to other tpRVAD systems. Several advantages exist compared to other RVAD systems.