bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Flood Forecasts capability of Taihang Piedmont Basin by coupling WRF and HEC-HMS
Authors: Zhang Ting , Gao Ya , Yu Ping , Li Jianzhu , Feng Ping , Ma Hui Xin 
Published: July 2023

Abstract
Based on numerical weather prediction model Weather Research and Forecasting (WRF) and Hydrologic Modeling System (HEC-HMS), a coupling model is constructed in Taihang Piedmont basin. The WRF model parameter scheme combinations composed of microphysics, planetary boundary layers (PBL), and cumulus parameterizations suitable for the study area are optimized. In both time and space, we tested the effects of the WRF model by a multi-index evaluation system composed of relative error (RE), root meantime square error (RMSE), probability of detection (POD), false alarm ratio (FAR), critical success index (CSI) and established this system in two stages. A multi-attribute decision-making model based on TOPSIS (Technique for Order Preference by Similarity to an Ideal Solution) and grey correlation degree is proposed to optimize each parameter scheme. Among eighteen parameter scheme combinations, Mellor-Yamada-Janjic (MYJ), Grell-Devinji (GD), Purdue-Lin (Lin), Mellor-Yamada-Janjic (MYJ), Betts-Miller-Janjić (BMJ), Single-Moment6(WSM6) are ideal choices according to the simulation performance in both time and space. Using the unidirectional coupling method, the rolling rainfall forecast results of the WRF model in the 24h and 48h forecast periods are input to HEC-HMS hydrological model to simulate three typical floods. The coupling simulation results are better than the traditional forecast method, and it prolongs the flood forecast period of the Taihang Piedmont basin.
In Situ Breast Cancer Surgeries in Sweden: Lumpectomy or Mastectomy? - A Cost-Utility Analysis in a 30-Year Time Period Using Markov Model
Authors: Pham Phu Duy , Muchadeyi Muchandifunga Trust , Lindholm Lars 
Published: July 2023

Abstract
Background:Breast cancer is the most prevalent cancer among Swedish women, and while treatments have progressed significantly over the years, there have been few health economics assessments of these treatments, particularly cost effectiveness analysis. This study was to evaluate the cost-effectiveness of three surgical procedures for in situ breast cancer treatment in Sweden: mastectomy, lumpectomy without irradiation, and lumpectomy with irradiation.
Methods:A 6-state Markov model with a 30-year time horizon was used to compare the cost-utility of these three alternatives. Transition probabilities were based on a targeted literature review focusing on available evidence in Sweden and similar contexts. Healthcare and societal perspectives were both considered in cost estimation using the Swedish National Cancer Registry patient data in 2020 (Cancerregistret), and a quality-adjusted life years (QALYs) was used to calculate utility. Probabilistic sensitivity analysis (PSA) was applied to handle uncertainties among the parameters.
Results:The results showed that lumpectomy with irradiation are cost-effective compared to lumpectomy without irradiation with an incremental cost effectiveness ratio (ICER) of 402,994 Swedish Krona (SEK) from a healthcare perspective and of 575,833 SEK from a societal perspective. Mastectomy alternative was dominated by the two lumpectomy alternatives, as it was the costliest option and yielded the lowest QALYs over the 30-year period. PSA results also supported the findings.
Conclusions:This study conducted a cost-utility analysis of three surgical procedures for in situ breast cancer treatment in Sweden, namely mastectomy, lumpectomy without and with irradiation. Further studies are needed to obtain more reliable parameters in Sweden and increase the consistency of the findings.
How does crystalline solids form from solution? Crystallization of lanthanide(III) hydroxides
Authors: Sørensen Thomas Just , Nielsen Villads , Aalling-Frederiksen Olivia , Jensen Kirsten 
Published: July 2023

Abstract
Technology and innovation requires new high performance materials, however our knowledge of how crystalline materials are formed is limited.1-5
We can control the growth of single crystals from melts and make semiconductors, optical fibers, and jet turbine blades.6 And we can with atomic precision make molecular architectures in the lab,7 or by exploiting biotechnological advances.8
However, where we for the creation of molecular species have a detailed mechanistic understanding, we do not have a succinct model that describes the formation mechanism of crystalline materials from solutions containing the molecular building blocks.9-11
Here we show that the formation of lanthanide(III) hydroxide crystallites does not take place in solutions,12-17 but happens upon dehydration on the filter. The data reveals that no solids are present in solution and that no crystallization occur. In solution a strong, washable gel phase is formed. Using total scattering,18-21 it is documented that no long range order is present in solutions, and that the gel is constructed from clusters of lanthanide(III) ions.
Despite the emergence of studies of the structure of crystallites in solutions and in melts,22-31 the early stages of formation of solids from ions and molecules in solution remains poorly understood.21, 32-34
The process from solvated ion to cluster to agglomerate can be described like any other chemical transformation, and must follow a reaction profile with energy barriers, intermediates, and transition states—and will be governed by reaction kinetics and thermodynamics. The first step is to map all species involved between solute and nanocrystal, and here studying materials made from lanthanide(III) ions are useful as luminescence, electron miscopy and scattering is strong with these ions.
Modular, Automated Synthesis of Spirocyclic Tetrahydronaphthyridines from Primary Alkylamines
Authors: Cresswell Alexander , Cao Qiao , Tibbetts Joshua , Wrigley Gail , Smalley Adam 
Published: July 2023

Abstract
Spirocyclic tetrahydronaphthyridines (THNs) are valuable scaffolds for drug discovery campaigns, but access to this 3D chemical space is hampered by a lack of modular and scalable synthetic methods. We hereby report a fully automated, continuous flow synthesis of α alkylated and spirocyclic 1,2,3,4-tetrahydro-1,8-naphthyridines (“1,8-THNs”), in addition to their regioisomeric 1,6 THN analogues, from abundant primary amine feedstocks. An annulative disconnection approach based on photoredox-catalysed hydroaminoalkylation (HAA) of halogenated vinylpyridines is sequenced in combination with intramolecular SNAr N arylation. To access the remaining 1,7- and 1,5-THN isomers, a photoredox-catalysed HAA step is telescoped with a palladium-catalysed C–N bond formation. Altogether, this provides a highly modular access to four isomeric THN cores from a common set of unprotected primary amine starting materials, using the same bond disconnections. The simplifying power of the methodology is illustrated by a concise synthesis of the spirocyclic THN core of Pfizer’s MC4R antagonist PF-07258669, reducing the previous step count by 67%.
Outcome dissimilarities in age group and delivery modality studied in the prediabetes Lifestyle Change Program conducted by Virginia Cooperative Extension
Authors: Pourkhalili Azin , Rafie Carlin , Margheim Lynn , Sarshar Arash 
Published: July 2023

Abstract
BACKGROUND:
The National Diabetes Prevention Program established by the Centers for Disease Control and Prevention promotes the implementation of an evidence-based lifestyle change program (LCP) to prevent or delay the onset of diabetes. The LCP is a 12-month program with 26 lessons covering topics on healthy diets, increasing physical activity, managing stress, and coping with triggers, among others. It includes weekly goal-setting, food and physical activity tracking, and group support. The program goals are 5-7% sustained weight loss and 150 minutes of physical activity weekly. Little is known about the real-world effectiveness of the LCP in different age groups, particularly in older adults.
OBJECTIVES:
The aim of this study was to evaluate the effects of age on LCP outcomes conducted by Virginia Cooperative Extension between 2018–2022 with the following objectives:
(a) Evaluate the effects of age on LCP outcomes in different age groups.
(b) Evaluate how LCP delivery methods (in-person and distance learning) influence program outcomes.
PARTICIPANTS:
189 participants enrolled in the LCP, 139 (73%) completed eight or more sessions, and 56% were above 60 years of age. Among the enrolled population, 51% of participants enrolled in the distance learning LCP program, while 49% preferred in-person.
METHODS :
To assess the differences in LCP outcomes between different age groups and delivery modalities, we performed t-tests followed up by post-hoc tests.
RESULTS:
At six months, participants 60 years and older had significantly higher attendance compared to participants under 60 years old (17 vs. 15, p<0.001). When considering the program delivery methods, participants 60 years and older had significantly higher attendance in distance learning programs by the end of six (15 vs. 17, p<0.001) and 12 months (18 vs. 21, p<0.001). Also, this age group who attended the distance learning programs had significantly higher weight loss compared to those who attended the in-person program at the end of the six months (4.61% vs. 2.07, p=0.02). Meanwhile, 86 persons (62%) had at least an average of 150 minutes of physical activity per week by the end of the program. Among them, the majority were 60 and older (67%) and enrolled in in-person programs (64%).
CONCLUSION:
The results showed that older participants were more successful than their younger counterparts in meeting LCP goals. These findings suggest that targeting different age groups and intervention delivery methods can improve program outcomes.
Bioactivity of Raphanus Species against Agricultural Phytopathogens and
its Role in Soil Remediation: A Review
Authors: Seimandi Gisela Marisol , Imhoff Silvia del Carmen , Derita Marcos Gabriel 
Published: July 2023

Abstract:
Phytopathogens and weeds represent around 20-40% of global agricultural productivity
losses. Synthetic pesticide products are the most used to combat these pests, but it reiterates that
their use has caused tremendous pressure on ecosystems' self-cleansing capacity and resistance development
by pathogens to synthetic fungicides. In the last decades, researchers have demonstrated
the vast biological properties of plants against pathogens and diseases. Raphanus species (Brassicaceae)
possesses antimicrobial, antioxidant, anti-inflammatory, anticancer, hepatoprotective, antidiabetic,
insecticidal, nematicidal, allelopathic, and phytoremediators properties. These are due to
the presence of structurally diverse bioactive compounds, such as flavonoids and glucosinolates. In
this review, we have provided an update on the biological properties of two Raphanus species (R.
sativus and R. raphanistrum), detailing the type of natural product (extract or isolated compound),
the bioassays displayed, and the results obtained for the main bioactivities of this genus cited in the
literature during the last 30 years. Moreover, preliminary studies on phytopathogenic activities performed
in our laboratory have also been depicted. We conclude that Raphanus species could be a
source of natural bioactive molecules to treat phytopathogens and weeds that affect crops and
remediate contaminated soils.
Graded Effects of Dry-Feed Added Sodium Benzoate/Ascorbic Acid
Combination on Neurobehaviour, Oxidative Stress, and Markers of
Inflammation in Mice
Authors: Olofinnade Anthony Tope , Onaolapo Adejoke Yetunde , Onaolapo Olakunle James 
Published: July 2023

Background:
Several concerns regarding the safety of sodium benzoate/ascorbic acid combination have been highlighted in various scientific investigations. However, there is a dearth of scientific literature on its effect on the brain. This study investigated the effects of dry-feed added sodium benzoate/ascorbic acid combination on neurobehaviour, oxidative stress, and inflammatory cytokines in mice

Methods:
Adult male mice were assigned into ten groups of 10 mice each. One group was fed a standard diet, three groups were fed a diet containing sodium benzoate (NaB) at 125 mg/kg with ascorbic acid (AA) at 100, 200, or 300 mg/kg of feed, another three groups were fed NaB at 250 mg/kg with AA at 100, 200, or 300 mg/kg of feed, respectively, and the last three groups were fed NaB at 500 mg/kg with AA at 100, 200 or 300 mg/kg, respectively. Behavioural tests were assessed, following which animals were sacrificed, and their brains were homogenised for the assessment of biochemical parameters.

Results:
The result showed a decrease in body weight, self-grooming, total antioxidant capacity, inflammatory cytokines, mixed response with food intake, locomotor activity, Y maze spatial working memory, and anxiety-related behaviours and an increase in rearing and radial arm maze spatial working memory.

Conclusion:
Dry-feed added NaB/AA altered behavioural, oxidative stress, and inflammatory markers in mice. It was found that both beneficial and deleterious effects might be possible, depending on the concentrations ingested in food. However, further investigations are required to ascertain its effects on humans.
Role of cognitive behavior therapy on people with substance abuse in the craving phase
Authors: Megada Anak Agung Gede Agung Satrya , Aryani Luh Nyoman Alit 
Published: July 2023

The problem of substance abuse has shown an increase in quantity, quality, and rate of distribution, both in terms of the number of victims and the types of substance abuse. World drug reports around 275 million people used drugs worldwide in 2020. In Indonesia, there are 3.66 million drug users in 2021. When people with substance abuse stop taking the substance and have the desire to take it again, it is called the craving phase. The case is a 36-year-old male with Mental and Behavioral Disorders Due to the Use of Other Stimulants With Uncomplicated Substance Withdrawal (F15.30). The patient wants to stop using crystal methamphetamine because there’s a desire to use it again in the last 3 weeks after stopping two months ago. This patient is in the craving phase, and CBT is the most therapy given to prevent relapse, beside CBT patient is also given other non-medical therapy in the form of supportive psychotherapy, motivational interviewing, and family therapy, for the medical therapy Fluoxetine 10 mg tab every 24 hours IO (in the morning) and Alprazolam 1 mg tab every 24 hours IO (in the evening).
Study the genetic polymorphisms of ABCB1 3435G>A in postmenopausal women breast cancer on Paclitaxel chemotherapy
Authors: Mohammed Hasan Doaa Alaa , Sahib Ahmed Salih , Al-Rokan Ahmed Abbas Hasan , Mohsin Karrar Kadhim 
Published: July 2023

Objectives: The aim of study was to determine the relationship between this SNPs in postmenopausal women with breast cancer 3435G>A (rs1045642) polymorphism of the ABCB1 gene, and serum concentrations of Paclitaxel chemotherapy in Iraq.
Methods: This study included 100 patients (45-75 years) with a clinical diagnosis of breast cancer who were going to start (paclitaxel) chemotherapy. Patients at the oncology center at Imam al-Hussain medical city in Kerbala Iraq, were sorted into groups based on their postmenopausal age, disease duration, and treatment length for this study, which was conducted between July 2022 and October 2022. Serum concentrations of Estradiol and Ca 15.3 were measured in breast cancer patients who had been taking Paclitaxel . Allele-Specific PCR assay determined gene polymorphisms 3435G>A (rs1045642) and HPLC measured paclitaxel drug concentration.
Results: The results found There is an inverse relationship between Ca15.3 concentration and patient response to paclitaxel chemotherapy, and when compared to the genotyping frequency of ABCB1 3435G>A (rs1045642) genetic polymorphism, patients with allele AA in their chromosomes respond better (15.56±6.89) than those with alleles GG and GA.
Conclusion: After paclitaxel chemotherapy, there were statistically significant differences (p< 0.05) in the reduction of drug concentration among serum patients with the AA genotype for ABCB1 3435G>A (rs1045642).
Optimasi Rute Pendistribusian Gas Elpiji Menggunakan Algoritma Floyd Warshall Dan Algoritma Greedy
Authors: Ningrum Elia Resita , Sanwidi Ardhi , Akbarita Rachmadania , Qomaruddin Muhammad Nur Haqqul 
Published: July 2023

Penelitian ini bertujuan untuk mencari hasil rute terpendek untuk distribusi LPG menggunakan algoritma Floyd-Warshall dan Greedy serta menemukan jalur terpendek yang lebih optimal antara kedua algoritma tersebut. Optimasi rute distribusi pada penelitian ini dilakukan dengan meminimalkan jarak yang akan ditempuh oleh kendaraan distribusi. Algoritma Floyd-Warshall dan algoritma Greedy merupakan metode optimasi dengan graf berbobot yang memiliki titik sebagai titik lokasi dan sisi sebagai jarak. Instrumen penelitian ini adalah aplikasi Google Maps yang disusun dalam tabel-tabel yang tersedia, dan laporan dari PT Petro Jaya Gas yang juga berbentuk tabel. Dalam menganalisis data menggunakan algoritma Floyd-Washall didapatkan simpul-simpul dari jalur distribusi - dengan total jarak 13,89 km, dan waktu tempuh 48 menit. Sedangkan dalam menganalisis data dengan menggunakan algoritma Greedy didapatkan simpul dari jalur distribusi adalah 10 dengan total jarak 13,13 km, dan waktu tempuh 45 menit. Berdasarkan hasil analisis dapat disimpulkan bahwa metode yang paling optimum yang dapat digunakan untuk menyelesaikan masalah rute terpendek dalam pendistribusian LPG PT Petro Jaya Gas adalah dengan menggunakan algoritma Greedy.
Kata kunci : Floyd Warshall, Greedy, Optimasi rute terpendek.
Analisis Produktivitas Penjualan Buket Bunga dan Selempang Pada Darul Creative Kayu Putih
Authors: Adoe Vera Selviana , Tato Maria Covalista , Udjan Maria Fianei Peni , Kasse Simon 
Published: July 2023

Darul Creative adalah salah satu tempat usaha yang memanfaatkan kreativitas dalam pembuatan buket bunga dan selempang. kemampuan dalam merangkai bunga dan menjahit yang di kembangkan atau dikreativitaskan dalam bentuk buket bunga dan selempang. oleh karena itu peneliti menganalisis produktivitas penjualan buket bunga dan selempang menggunakan metode simplex dualitas yang dapat menunjang produktifitas pada pembuatan buket bunga dan selempang. Penelitian ini bertujuan untuk mengetahui produktivitas pada pada Darul Creative dengan menggunakan linear programming metode simpleks dualitas dibantu menggunakan aplikasi POM QM for Windows. Hasil dari penelitian yang ini menunjukkan bahwa untuk dapat memaksimumkan produk dalam optimasi produksi buket bunga dan selempang, menggunakan metode simpleks menunjukkan buket bunga merupakan produk yang lebih dengan valuenya 3, dan untuk selempang merupakan produk pilihan dengan dalam produksi dengan value masing-masing 3.5. Banyaknya jumlah produksi optimum yang diproduksi dapat mencapai keuntungan yang maksimum.
Kata kunci : Darul Creative, Linear Programming, Produktifitas, POM QM.
The Effect of the Use of Contextual Teaching and Learning (CTL) Approach on Elementary School Student Learning Outcomes about Science Grade IV to Ampera
Authors: Kombu Abraham F. P. , Nuryanti Siti , Rede Amran 
Published: July 2023

This reseacrh intends to examine the effect of the contextual teaching and learning outcomes of science students grade IV Ampera. The research used a quasi-experiment with equivalent pretest-posttest design and the subbject was class IVa students (n=20) as an experimental class and students class IVb (n=20) as a control class. Data collection techniques were carried out by observation and learning outcomes tests. Data analysis was performed with the t-test at a siqnificance level of 0.05 that were previously tested the prerequisites (normality and homogeneity). Hypothesis testing was done by the n-gain test. The results showed an increase in the average value of n-gain in the experimental class was 0.67 while in the control class was 0.46. The average value in the experimental class was 81.45 and the control was 69.05, while t-test was obtained t count 7.62 and t table 1.68 t hus t count > t table (7.62 > 1.68). This proves that there is a siqnificant influence on the contextual teaching and learning (CTL) approach on student learning outcomes.
Effect of Discovery Learning Implementation Model on Buffer Solution Material on Critical Thinking Ability and Metacognition Awareness of Senior High School Students
Authors: Firmansah Firmansah , Aminah Aminah , Said Irwan 
Published: July 2023

This study aims to determine the effect of applying the discovery learning model on critical thinking skills and metacognitive awareness of class XI IPA students at SMA Negeri 3 Palu. The research method used is a quasi-experimental design with a pretest-posttest control group design. The results of the statistical test for critical thinking skills obtained sig = 0.001 and metacognitive awareness sig = 0.031 with the criteria of accepting H0 if Sig. > 0.05 and reject H0 if Sig. <0.05. sig. value < 0.05, then H0 is rejected. While the correlation test obtained sig. = 0.966 so that H0 is accepted. The results showed that: (1) the application of the discovery learning model had a positive effect on students' critical thinking skills in the buffer solution material, (2) the application of the discovery learning model had a positive effect on students' metacognitive awareness in the buffer solution material, (3) there was no relationship between the ability critical thinking and metacognitive awareness of students on buffer solution material.
KUALITAS PELAYANAN PERPUSTAKAAN KELILING DI DINAS ARSIP DAN PERPUSTAKAAN KABUPATEN SUMEDANG
Authors: Febianti Fepi , Kuswara  
Published: July 2023

Mobile libraries are one of the programs of public libraries to serve people who are not reached or difficult to reach by public library services, considering the limitations and weaknesses of public libraries. One of the purposes of mobile library services is to provide information and science services more closely. The Regional Public Library and Archives Office of Sumedang Regency is a government facility as a service to the community, which aims to provide sources of information materials in the form of reading books and other archives. The methods used in this study are descriptive survey methods and literature studies. The descriptive method is a method that seeks to solve or answer the problems faced in the current situation. Based on the analysis and discussion, it was concluded that the quality of mobile library services at the Archives and Library Office has not been effective and efficient in meeting the needs of the community. The quality of service from the tangible aspect is the condition of the vehicle that only has 1 functioning so it is difficult to reach many areas. The quality of service from the aspect of reliability, namely scheduling in mobile library services, has not been well scheduled. Even for routine schedules have not been implemented. The quality of service from the aspect of responsiveness is that the service of librarians is not good because it does not quickly respond to the needs of visitors and cannot help visitors who have difficulty finding books optimally. The quality of service from the assurance aspect, namely the officers have not been friendly and polite, the officers have not been able to answer questions asked by visitors, and there has been no rearrangement of what book collections need to be fulfilled if making a tour visit with the aim of meeting the information needs of the people of Sumedang. The quality of service from the emphaty aspect is that officers have not been able to manage tools in the library. Officers have not been able to help visitors if they have difficulty in finding the information needed.