bluuebunny/crossref_metadata_2025_split huggingface dataset:
Level pinning of anti-PT-symmetric circuits for efficient wireless power transfer
Authors: Guo Zhiwei , Yang Fengqing , Zhang Haiyan , Wu Xian , Wu Qiong , Zhu Kejia , Jiang Jun , Jiang Haitao , Yang Yaping , Li Yunhui , Chen Hong 
Published: June 2023

ABSTRACT
Wireless power transfer (WPT) technology based on magnetic resonance (a basic physical phenomenon) can directly transfer energy from the source to the load without wires and other physical contacts, and has been successfully applied to implantable medical devices, electric vehicles, robotic arms and other fields. However, due to the frequency splitting of near-field coupling, the resonant WPT system has some unique limitations, such as poor transmission stability and low efficiency. Here, we propose anti-resonance with level pinning for high-performance WPT. By introducing the anti-resonance mode into the basic WPT platform, we uncover the competition between dissipative coupling and coherent coupling to achieve novel level pinning, and construct an effective anti-parity-time (anti-PT)-symmetric non-Hermitian system that is superior to previous PT-symmetric WPT schemes. On the one hand, the eigenvalue of the anti-PT-symmetric system at resonance frequency is always pure real in both strong and weak coupling regions, and can be used to overcome the transmission efficiency decrease caused by weak coupling, as brought about by, for example, a large size ratio of the transmitter to receiver, or a long transmission distance. On the other hand, due to the level pinning effect of the two kinds of coupling mechanisms, the working frequency of the system is guaranteed to be locked, so frequency tracking is not required when the position and size of the receiver change. Even if the system deviates from the matching condition, an efficient WPT can be realized, thereby demonstrating the robustness of the level pinning. The experimental results show that when the size ratio of the transmitter coil to the receiver coil is 4.29 (which is in the weak coupling region), the transfer efficiency of the anti-PT-symmetric system is nearly 4.3 (3.2) times higher than that of the PT-symmetric system when the matching conditions are satisfied (deviated). With the miniaturization and integration of devices in mind, a synthetic anti-PT-symmetric system is used to realize a robust WPT. Anti-PT-symmetric WPT technology based on the synthetic dimension not only provides a good research platform for the study of abundant non-Hermitian physics, but also provides a means of going beyond traditional near-field applications with resonance mechanisms, such as resonance imaging, wireless sensing and photonic routing.
Magnetic configurations related to the coronal heating and solar wind generation. II. Quantitative characterization of active-region magnetic structure based on the geometric property of force-free α
Authors: Jang Yeonwoo , Yi Sibaek , Magara Tetsuya 
Published: June 2023

Abstract
We investigate the geometric property of a scalar position function, the so-called force-free α, to see how it quantitatively characterizes the magnetic structure of solar active regions, which is reminiscent of the electrostatic potential whose geometric property provides information on the structure of electrified objects. Scatter plots of (α, ∇2α) show characteristic shapes representing twisted magnetic field configurations in two model active regions, one of which is formed by an emerging magnetic flux tube composed of strongly twisted field lines while the other is formed by a weakly twisted flux tube. By generalizing the concept of an axis field line in a uniformly twisted cylindrical flux tube, we introduce a topological object called the principal field line to represent magnetic structure reconstructed using a force-free field model. The principal field line and associated scatter plot of (α, ∇2α) provide a method reminiscent of active-region radiography, which could be used for quantitative classification of active regions with those magnetic configurations responsible for heating coronal plasmas, generating solar winds, and producing potentially harmful coronal explosive phenomena.
Sandwich-Gen on young people and their mental health issues: how to connect financial responsibility and avoid loneliness
Authors: Nawantara Rosalia D , Hanurawan Fattah , Ramli M , Eva Nur , Hidayah Nur 
Published: June 2023

Abstract
The sandwich generation in youth and their mental health issues sometimes go unnoticed. Financial responsibilities that cause social isolation increase the potential to feel lonely. On the other hand, knowledge regarding final responsibility is also needed by young people. Responding to these two things, it is necessary to design policies that are relevant to the need for mental health services for the younger generation as a sandwich generation.
A novel machine learning-assisted clinical diagnosis support model for early identification of pancreatic injuries in patients with blunt abdominal trauma: a cross-national study
Authors: Huang Sai , Zhang Xuan , Yang Bo , Teng Yue , Mao Li , Wang Lili , Wang Jing , Zhou Xuan , Chen Li , Yao Yuan , Feng Cong 
Published: June 2023

Abstract

Background
The recognition of pancreatic injury in blunt abdominal trauma is often severely delayed in clinical practice. The aim of this study was to develop a machine learning model to support clinical diagnosis for early detection of abdominal trauma.

Methods
We retrospectively analyzed of a large intensive care unit database (Medical Information Mart for Intensive Care [MIMIC]-IV) for model development and internal validation of the model, and performed outer validation based on a cross-national data set. Logistic regression was used to develop three models (PI-12, PI-12-2, and PI-24). Univariate and multivariate analyses were used to determine variables in each model. The primary outcome was early detection of a pancreatic injury of any grade in patients with blunt abdominal trauma in the first 24 hours after hospitalization.

Results
The incidence of pancreatic injuries was 5.56% (n = 18) and 6.06% (n = 6) in the development (n = 324) and internal validation (n = 99) cohorts, respectively. Internal validation cohort showed good discrimination with an area under the receiver operator characteristic curve (AUC) value of 0.84 (95% confidence interval [CI]: 0.71–0.96) for PI-24. PI-24 had the best AUC, specificity, and positive predictive value (PPV) of all models, and thus it was chosen as the final model to support clinical diagnosis. PI-24 performed well in the outer validation cohort with an AUC value of 0.82 (95% CI: 0.65–0.98), specificity of 0.97 (95% CI: 0.91–1.00), and PPV of 0.67 (95% CI: 0.00–1.00).

Conclusion
A novel machine learning-based model was developed to support clinical diagnosis to detect pancreatic injuries in patients with blunt abdominal trauma at an early stage.
The Use of Free Vascularized Fibula Graft in Spinal Reconstruction: A Comprehensive Systematic Review
Authors: Riasa I Nyoman P. , Kawilarang Bertha 
Published: June 2023

Background:
Reconstructive surgeons frequently face large structural abnormalities after spine resection. Unlike defects in the mandible or long bone, where a free vascularized fibular graft (FVFG) is a popular alternative for segmental osseous reconstruction, data on the use of an FVFG in the spine are still limited. The purpose of this study was to comprehensively describe and analyze the outcome of spinal reconstruction utilizing FVFG.

Methods:
The extensive search included the following databases: PubMed, ScienceDirect, Web of Science, Cumulative Index to Nursing and Allied Health Literature, and Cochrane for relevant studies published up to January 20, 2023, according to PRISMA 2020 guidelines. Demographic data, flap success, recipient vessels, and flap-related complications were evaluated.

Results:
We identified 25 eligible studies involving 150 patients, consisting of 82 men and 68 women. Spinal reconstruction utilizing FVFG is mostly reported in the case of spinal neoplasm, followed by spinal infection (osteomyelitis and spinal tuberculosis) and spinal deformities. The cervical spine is the most common vertebral defect reported in the studies. All studies summarized in the present study reported successful spinal reconstruction, while wound infection was the most reported postoperative complication after spinal reconstruction utilizing FVFG.

Conclusions:
The results of the current study highlight the ability and superiority of using FVFG in spinal reconstruction. Despite being technically challenging, this strategy provides enormous benefits to patients. However, a further additional large-scale study is required to corroborate these findings.
Deep RNA-seq of male and female murine sensory neuron subtypes after nerve injury
Authors: Barry Allison M. , Zhao Na , Yang Xun , Bennett David L. , Baskozos Georgios 
Published: June 2023

Abstract
Dorsal root ganglia (DRG) neurons have been well described for their role in driving both acute and chronic pain. Although nerve injury is known to cause transcriptional dysregulation, how this differs across neuronal subtypes and the impact of sex is unclear. Here, we study the deep transcriptional profiles of multiple murine DRG populations in early and late pain states while considering sex. We have exploited currently available transgenics to label numerous subpopulations for fluorescent-activated cell sorting and subsequent transcriptomic analysis. Using bulk tissue samples, we are able to circumvent the issues of low transcript coverage and drop-outs seen with single-cell data sets. This increases our power to detect novel and even subtle changes in gene expression within neuronal subtypes and discuss sexual dimorphism at the neuronal subtype level. We have curated this resource into an accessible database for other researchers (https://livedataoxford.shinyapps.io/drg-directory/). We see both stereotyped and unique subtype signatures in injured states after nerve injury at both an early and late timepoint. Although all populations contribute to a general injury signature, subtype enrichment changes can also be seen. Within populations, there is not a strong intersection of sex and injury, but previously unknown sex differences in naïve states—particularly in Aβ-RA + Aδ-low threshold mechanoreceptors—still contribute to differences in injured neurons.
Inhibition of persistent sodium current reduces spreading depression-evoked allodynia in a mouse model of migraine with aura
Authors: Morais Andreia , Qin Tao , Ayata Cenk , Harriott Andrea M. 
Published: June 2023

Abstract
We investigated the efficacy of inhibiting persistent Na+ currents (INaP) in acute rodent models of migraine with aura. Cortical spreading depression (SD) is a slow wave of neuronal and glial depolarization that underlies the migraine aura. Minimally invasive optogenetic SD (opto-SD) causes periorbital mechanical allodynia in mice, suggesting SD activates trigeminal nociceptors. Persistent Na+ currents contribute to neuronal intrinsic excitability and have been implicated in peripheral and cortical excitation. We examined a preferential inhibitor of INaP, GS-458967, on SD-induced periorbital allodynia, SD susceptibility, and formalin-induced peripheral pain. Periorbital mechanical allodynia was tested in male and female Thy1-ChR2-YFP mice after a single opto-SD event using manual von Frey monofilaments. GS-458967 (1 mg/kg, s.c.) or vehicle was dosed immediately after opto-SD induction, and allodynia was tested 1 hour later. The electrical SD threshold and KCl-induced SD frequency were examined in the cortex in male Sprague–Dawley rats after 1 hour pretreatment with GS-458967 (3 mg/kg, s.c.) or vehicle. Effects of GS-458967 (0.5-5 mg/kg, p.o.) on spontaneous formalin hind paw behavior and locomotion were also examined in male CD-1 mice. GS-458967 suppressed opto-SD–induced periorbital allodynia and decreased susceptibility to SD. GS-458967 also diminished early and late phase formalin-induced paw-licking behavior with early phase paw licking responding to lower doses. GS-458967 up to 3 mg/kg had no impact on locomotor activity. These data provide evidence that INaP inhibition can reduce opto-SD–induced trigeminal pain behavior and support INaP inhibition as an antinociceptive strategy for both abortive and preventive treatment of migraine.
Ambulatory daytime blood pressure versus tonometric blood pressure measurements in the laboratory: effect of posture
Authors: Värri Emmi , Suojanen Lauri , Koskela Jenni K. , Choudhary Manoj K. , Tikkakoski Antti , Kähönen Mika , Nevalainen Pasi I. , Mustonen Jukka , Pörsti Ilkka 
Published: June 2023

Objective
To compare blood pressure (BP) in tonometric radial artery recordings during passive head-up tilt with ambulatory recordings and evaluate possible laboratory cutoff values for hypertension.

Methods
Laboratory BP and ambulatory BP were recorded in normotensive (n = 69), unmedicated hypertensive (n = 190), and medicated hypertensive (n = 151) subjects.

Results
Mean age was 50.2 years, BMI 27.7 kg/m2, ambulatory daytime BP 139/87 mmHg, and 276 were male (65%). As supine-to-upright changes in SBP ranged from −52 to +30 mmHg, and in DBP from -21 to +32 mmHg, the mean values of BP supine and upright measurements were compared with ambulatory BP. The mean(supine+upright) systolic laboratory BP was corresponding to ambulatory level (difference +1 mmHg), while mean(supine+upright) DBP was 4 mmHg lower (P < 0.05) than ambulatory value. Correlograms indicated that laboratory 136/82 mmHg corresponded to ambulatory 135/85 mmHg. When compared with ambulatory 135/85 mmHg, the sensitivity and specificity of laboratory 136/82 mmHg to define hypertension were 71.5% and 77.3% for SBP, and 71.7% and 72.8%, for DBP, respectively. The laboratory cutoff 136/82 mmHg classified 311/410 subjects similarly to ambulatory BP as normotensive or hypertensive, 68 were hypertensive only in ambulatory, while 31 were hypertensive only in laboratory measurements.

Conclusion
BP responses to upright posture were variable. When compared with ambulatory BP, mean(supine+upright) laboratory cutoff 136/82 mmHg classified 76% of subjects similarly as normotensive or hypertensive. In the remaining 24% the discordant results may be attributed to white-coat or masked hypertension, or higher physical activity during out-of-office recordings.
Artificial Intelligence in Minimally Invasive Adrenalectomy: Using Deep Learning to Identify the Left Adrenal Vein
Authors: Sengun Berke , Iscan Yalin , Tataroglu Ozbulak Gozde A. , Kumbasar Nida , Egriboz Emre , Sormaz Ismail C. , Aksakal Nihat , Deniz Sencer M. , Haklidir Mehmet , Tunca Fatih , Giles Senyurek Yasemin 
Published: June 2023

Background:
Minimally invasive adrenalectomy is the main surgical treatment option for the resection of adrenal masses. Recognition and ligation of adrenal veins are critical parts of adrenal surgery. The utilization of artificial intelligence and deep learning algorithms to identify anatomic structures during laparoscopic and robot-assisted surgery can be used to provide real-time guidance.

Methods:
In this experimental feasibility study, intraoperative videos of patients who underwent minimally invasive transabdominal left adrenalectomy procedures between 2011 and 2022 in a tertiary endocrine referral center were retrospectively analyzed and used to develop an artificial intelligence model. Semantic segmentation of the left adrenal vein with deep learning was performed. To train a model, 50 random images per patient were captured during the identification and dissection of the left adrenal vein. A randomly selected 70% of data was used to train models while 15% for testing and 15% for validation with 3 efficient stage-wise feature pyramid networks (ESFPNet). Dice similarity coefficient (DSC) and intersection over union scores were used to evaluate segmentation accuracy.

Results:
A total of 40 videos were analyzed. Annotation of the left adrenal vein was performed in 2000 images. The segmentation network training on 1400 images was used to identify the left adrenal vein in 300 test images. The mean DSC and sensitivity for the highest scoring efficient stage-wise feature pyramid network B-2 network were 0.77 (±0.16 SD) and 0.82 (±0.15 SD), respectively, while the maximum DSC was 0.93, suggesting a successful prediction of anatomy.

Conclusions:
Deep learning algorithms can predict the left adrenal vein anatomy with high performance and can potentially be utilized to identify critical anatomy during adrenal surgery and provide real-time guidance in the near future.
Association of Historical Redlining and Present-Day Social Vulnerability with Cancer Screening
Authors: Moazzam Zorays , Woldesenbet Selamawit , Endo Yutaka , Alaimo Laura , Lima Henrique A , Cloyd Jordan , Dillhoff Mary , Ejaz Aslam , Pawlik Timothy M 
Published: June 2023

BACKGROUND:
The Healthy People 2030 initiative has set national cancer screening targets at 77.1%, 74.4%, and 84.3% for breast, colon, and cervical cancers, respectively. We sought to assess the association between historical redlining relative and present-day social vulnerability on screening targets for breast, colon, and cervical cancer.

STUDY DESIGN:
Data on national census-tract level cancer screening prevalence and social vulnerability index in 2020 was extracted from the CDC PLACES and CDC social vulnerability index databases, respectively. Census tracts were then assigned Home-Owners Loan Corporation grades (A: “Best”, B: “Still Desirable”, C: “Definitely Declining,” and D: “Hazardous/Redlined”). Mixed-effects logistic regression and mediation analyses were conducted to evaluate the association between Home-Owners Loan Corporation grades and achievement of cancer screening targets.

RESULT:
Among 11,831 census tracts, 3,712 were classified as redlined (A: n = 842, 7.1% vs B: n = 2,314, 19.6% vs C: n = 4,963, 42.0% vs D: n = 3,712, 31.4%). Notably, 62.8% (n = 7,427), 21.2% (n = 2,511), and 27.3% (n = 3,235) of tracts met screening targets for breast, colon, and cervical cancer, respectively. After adjusting for present-day social vulnerability index and access to care metrics (population to primary care physician ratio and distance to nearest healthcare facility), redlined tracts were markedly less likely to meet breast (odds ratio [OR] 0.76, 95% CI 0.64 to 0.91), colon (OR 0.34, 95% CI 0.28 to 0.41), and cervical (OR 0.21, 95% CI 0.16 to 0.27) cancer screening targets compared with the “Best” tracts. Notably, poverty, lack of education, and limited English proficiency, among others, mediated the adverse effect of historical redlining on cancer screening.

CONCLUSIONS:
Redlining as a surrogate for structural racism continues to adversely impact cancer screening. Policies that aim to make access to preventive cancer care more equitable for historically marginalized communities should be a public priority.
The Size of Fields in Biomedical Sciences
Authors: Dragotakes Quigly , Casadevall Arturo 
Published: June 2023

AbstractScientific research output has increased exponentially over the past few decades, but not equally across all fields of study, and we lack clear methods for estimating the size of any given field of research. Understanding how fields grow, change, and are organized is essential to understanding how human resources are allocated to the investigation of scientific problems. In this study we estimated the size of certain biomedical fields from the number of unique author names appearing in field relevant publications in the PubMed database. Focusing on microbiology, where the size of fields is often associated with those who work on a particular microbe, we find large differences in the size of its subfields. We found that plotting the number of unique investigators as a function of time can show changes consistent with growing or shrinking fields. We envision using unique author count to measure the strength of a workforce in any given field, analyze the overlap of workforce between fields, and compare how workforce correlates to available research funds and public health burden of a field.
Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response
Authors: Theusch Elizabeth , Ting Flora Y. , Qin Yuanyuan , Stevens Kristen , Naidoo Devesh , King Sarah M. , Yang Neil , Orr Joseph , Han Brenda Y. , Cyster Jason G. , Chen Yii-Der I. , Rotter Jerome I. , Krauss Ronald M. , Medina Marisa W. 
Published: June 2023

AbstractBackgroundStatins lower circulating low-density lipoprotein cholesterol (LDLC) levels and reduce cardiovascular disease risk. Though highly efficacious in general, there is considerable inter-individual variation in statin efficacy that remains largely unexplained.MethodsTo identify novel genes that may modulate statin-induced LDLC lowering, we used RNA-sequencing data from 426 control- and 2 μM simvastatin-treated lymphoblastoid cell lines (LCLs) derived from European and African American ancestry participants of the Cholesterol and Pharmacogenetics (CAP) 40 mg/day 6-week simvastatin clinical trial (ClinicalTrials.govIdentifier:NCT00451828). We correlated statin-induced changes in LCL gene expression with plasma LDLC statin response in the corresponding CAP participants. For the most correlated gene identified (ZNF335), we followed upin vivoby comparing plasma cholesterol levels, lipoprotein profiles, and lipid statin response between wild-type mice and carriers of a hypomorphic (partial loss of function) missense mutation inZfp335(the mouse homolog ofZNF335).ResultsThe statin-induced expression changes of 147 human LCL genes were significantly correlated to the plasma LDLC statin responses of the corresponding CAP participantsin vivo(FDR=5%). The two genes with the strongest correlations were zinc finger protein 335 (ZNF335akaNIF-1, rho=0.237, FDR-adj p=0.0085) and CCR4-NOT transcription complex subunit 3 (CNOT3, rho=0.233, FDR-adj p=0.0085). Chow-fed mice carrying a hypomorphic missense (R1092W; aka bloto) mutation inZfp335had significantly lower non-HDL cholesterol levels than wild type C57BL/6J mice in a sex combined model (p=0.04). Furthermore, male (but not female) mice carrying theZfp335R1092Wallele had significantly lower total and HDL cholesterol levels than wild-type mice. In a separate experiment, wild-type mice fed a control diet for 4 weeks and a matched simvastatin diet for an additional 4 weeks had significant statin-induced reductions in non-HDLC (−43±18% and -23±19% for males and females, respectively). Wild-type male (but not female) mice experienced significant reductions in plasma LDL particle concentrations, while male mice carryingZfp335R1092Wallele(s) exhibited a significantly blunted LDL statin response.ConclusionsOurin vitroandin vivostudies identifiedZNF335as a novel modulator of plasma cholesterol levels and statin response, suggesting that variation in ZNF335 activity could contribute to inter-individual differences in statin clinical efficacy.