bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dreams in Plutarch’sLivesof Alcibiades and Demosthenes
Authors: Catenaccio Claire 
Published: July 2023

AbstractThis article argues that theante mortemdreams of Alcibiades and Demosthenes articulate key themes of moral doubt in Plutarch’s biography of each man. Alcibiades’ dream of being dressed as a courtesan alludes to his uneasy stance between masculine and feminine postures; Demosthenes’ dream of himself as a failed tragic actor draws upon his lifelong concern with performance and insincerity. In these twoLives,Plutarch deploys the ambiguity and uncertainty of dreams to pose an interpretive problem for the reader which can never fully be resolved, particularly appropriate to these unpredictable and untrustworthy men.
Adaptive and iterative learning control to simultaneously control end-effector force and direction by normal vectors learning
Authors: Han Liang , Gao Yu , Huang Yunzhi , Xu Wenfu , He Lei 
Published: July 2023

AbstractIt is very challenging for robots to perform grinding and polishing tasks on surfaces with unknown geometry. Most existing methods solve this problem by modeling the relationship between the force sensing information and surface normal vectors by analyzing the forces on special end tools such as spherical tools and cylindrical tools and simplified friction model. In this paper, we propose a normal vectors learning method to simultaneously control end-effector force and direction on unknown surfaces. First, the relation that mapping the force sensing information to the surface normal vectors is learned from the demonstrated data on the known plane using locally weighted regression. Next, the learned relation is used to estimate surface normal vectors on the unknown surface. To improve the force control precision on the unknown geometry surface, the adaptive force control is developed. To improve the direction control precision due to friction, the iterative learning control is developed. The proposed method is verified by comparative simulations and experiments using the Franka robot. Results show that the end-effector can be controlled perpendicular to the surface with a certain force.
Stability in the integrated bilingual grammar: Tense exponency in North American Norwegian
Authors: Natvig David , Putnam Michael T. , Lykke Alexander K. 
Published: July 2023

AbstractDecades of research on bilingual grammars corroborate the integrated nature of these systems, leading to the conjecture that these representations are ‘shared’ (Marian & Spivey 2003, Kroll & Gollan 2014, Putnam et al. 2018). A specific population of bilinguals, namelyheritage language speakers, shows a tendency for highly variable allomorphy (Polinsky 2018, Putnam et al. 2021); however, with this aspect of grammar that is often in a state of flux, there are instances of stability. Here we thoroughly investigate the stability of tense allomorphy of in North American Norwegian (NAmNo), a moribund heritage language spoken in the Upper Midwestern United States. Formally, we build upon initial observations provided by Lykke (2020), showing how a late-insertion approach to the syntax–phonological interface in combination withevents, features, and precedence(EFP) phonology (Raimy 2000, Papillon 2020, Idsardi 2022) provides a straightforward account of the structural complexities that determine exponency in bilingual grammars.
Impact of Heavy Snowfall on Emergency Transport and Prognosis of Out-of-Hospital Cardiac Arrest Patients: A Nation-Wide Cohort Study
Authors: Omatsu Kentaro , Uchiyama Mieko , Shimizu Utako , Ling Yiwei , Okuda Shujiro , Koyama Yu 
Published: July 2023

AbstractBackground:Out-of-hospital cardiac arrest (OHCA) is a significant global cause of mortality, and Emergency Medical Services (EMS) response interval is critical for survival and a neurologically-favorable outcome. Currently, it is unclear whether EMS response interval, neurologically-intact survival, and overall survival differ between snowy and non-snowy periods at heavy snowfall areas.Methods:A nation-wide population-based cohort of OHCA patients, registered from 2017 through 2019 in the All-Japan Utstein Registry, was divided into four groups according to areas (heavy snowfall area or other area) and seasons (winter or non-winter): heavy snowfall-winter, heavy snowfall-non-winter, other area-winter, and other area-non-winter. The first coprimary outcome was EMS response interval, and the secondary coprimary outcome was one-month survival and a neurologically-favorable outcome at one month.Results:A total of 337,781 OHCA patients were divided into four groups: heavy snowfall-winter (N = 15,627), heavy snowfall-non-winter (N = 97,441), other area-winter (N = 32,955), and other area-non-winter (N = 191,758). Longer EMS response intervals (>13 minutes) were most likely in the heavy snowfall-winter group (OR = 1.86; 95% CI, 1.76 to 1.97), and also more likely in heavy snowfall areas in non-winter (OR = 1.44; 95% CI, 1.38 to 1.50). One-month survival in winter was worse not only in the heavy snowfall area (OR = 0.86; 95% CI, 0.78 to 0.94) but also in other areas (OR = 0.91; 95% CI, 0.87 to 0.94). One-month neurologically-favorable outcomes were also comparable between heavy snowfall-winter and other area-non-winter groups.Conclusions:This study showed OHCA in heavy snowfall areas in winter resulted in longer EMS response intervals. However, heavy snowfall had little effect on one-month survival or neurologically-favorable outcome at one month.
The Psychological Impacts and Message Features of Health	Misinformation
Authors: Schmid Philipp , Altay Sacha , Scherer Laura D. 
Published: July 2023

Abstract: What does health misinformation look like, and what is its impact? We conducted a systematic review of 45 articles containing 64 randomized controlled trials (RCTs; N = 37,552) on the impact of health misinformation on behaviors and their psychological antecedents. We applied a planetary health perspective by framing environmental issues as human health issues and focusing on misinformation about diseases, vaccination, medication, nutrition, tobacco consumption, and climate change. We found that in 49% of the cases exposure to health misinformation damaged the psychological antecedents of behaviors such as knowledge, attitudes, or behavioral intentions. No RCTs evaluated the impact of exposure to misinformation on direct measures of health or pro-environmental behaviors (e.g., vaccination), and few studies explored the impact of misinformation on feelings, social norms, and trust. Most misinformation was based on logical fallacies, conspiracy theories, or fake experts. RCTs evaluating the impact of impossible expectations and cherry-picking are scarce. Most research focused on healthy adult US populations and used online samples. Future RCTs can build on our analysis and address the knowledge gaps we identified.
Navigating Gender at Sea
Authors: McMonigal Kay , Evans Natalya , Jones Dani , Brett Jay , James Reece C. , Arroyo Mar C. , Gong A‐bel Y. , Miller Lee C. , Kelly Colette , Middleton Jule , Spear Chris , Holmes Wil , Lane Dakota 
Published: July 2023

AbstractFieldwork, including work done at sea, is a key component of many geoscientists' careers. Recent studies have highlighted the pervasive harassment faced by women and LGBTQ+ people during fieldwork. However, transgender and gender diverse (TGD) scientists face obstacles which have not yet been thoroughly examined. We fill this gap by sharing our experiences as TGD people. We have experienced sexual harassment, misconduct, privacy issues, and legal and medical struggles as we conduct seagoing work. In this work, we provide recommendations for individuals, cruise leaders, and institutions for making seagoing work safer for our communities.
Post‐Sunset Field‐Line Resonances at Equatorial Latitudes Observed by Swarm
Authors: Ghadjari Hossein , Knudsen David , Skone Susan 
Published: July 2023

AbstractIn this study employing data from the Swarm satellites at an altitude of ≈500 km, we present evidence of field‐line resonances (FLRs) in the Pc2‐3 (0.02–0.2 Hz) frequency band in the undisturbed post‐sunset region of the equatorial ionosphere. We identify 26 events extending to magnetic latitudes as low as 2°, which was previously thought to be too low for FLRs to exist due to ionospheric damping. Identification of FLRs is supported by a narrow‐band fundamental and first harmonics, an oscillating field‐aligned Poynting vector, a relative phase shift between E and δB of ≈90°, and in one case observation of one wave in conjugate hemispheres by two satellites separated by 4 min. We show that, contrary to the non‐uniform trend of ground‐based observations, the fundamental frequencies of these occurrences decline monotonically with increasing field‐line length. Their frequencies differ from those of ground‐based magnetometer observations reported in the literature.
Efferocytosis by bone marrow mesenchymal stromal cells disrupts osteoblastic differentiation via mitochondrial remodeling
Authors: Quarato Emily R. , Salama Noah A. , Li Allison J. , Smith Charles O. , Zhang Jane , Kawano Yuko , McArthur Matthew , Liesveld Jane L. , Becker Michael W. , Elliott Michael R. , Eliseev Roman A. , Calvi Laura M. 
Published: July 2023

AbstractThe efficient clearance of dead and dying cells, efferocytosis, is critical to maintain tissue homeostasis. In the bone marrow microenvironment (BMME), this role is primarily fulfilled by professional bone marrow macrophages, but recent work has shown that mesenchymal stromal cells (MSCs) act as a non-professional phagocyte within the BMME. However, little is known about the mechanism and impact of efferocytosis on MSCs and on their function. To investigate, we performed flow cytometric analysis of neutrophil uptake by ST2 cells, a murine bone marrow-derived stromal cell line, and in murine primary bone marrow-derived stromal cells. Transcriptional analysis showed that MSCs possess the necessary receptors and internal processing machinery to conduct efferocytosis, with Axl and Tyro3 serving as the main receptors, while MerTK was not expressed. Moreover, the expression of these receptors was modulated by efferocytic behavior, regardless of apoptotic target. MSCs derived from human bone marrow also demonstrated efferocytic behavior, showing that MSC efferocytosis is conserved. In all MSCs, efferocytosis impaired osteoblastic differentiation. Transcriptional analysis and functional assays identified downregulation in MSC mitochondrial function upon efferocytosis. Experimentally, efferocytosis induced mitochondrial fission in MSCs. Pharmacologic inhibition of mitochondrial fission in MSCs not only decreased efferocytic activity but also rescued osteoblastic differentiation, demonstrating that efferocytosis-mediated mitochondrial remodeling plays a critical role in regulating MSC differentiation. This work describes a novel function of MSCs as non-professional phagocytes within the BMME and demonstrates that efferocytosis by MSCs plays a key role in directing mitochondrial remodeling and MSC differentiation. Efferocytosis by MSCs may therefore be a novel mechanism of dysfunction and senescence. Since our data in human MSCs show that MSC efferocytosis is conserved, the consequences of MSC efferocytosis may impact the behavior of these cells in the human skeleton, including bone marrow remodeling and bone loss in the setting of aging, cancer and other diseases.
High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis
Authors: Cao Fang , Jiang Yunpeng , Chang Lin , Du Hongzhen , Chang De , Pan Chunxiao , Huang Xiaozheng , Yu Donglin , Zhang Mi , Fan Yongna , Bian Xiaocui , Li Kailong 
Published: July 2023

AbstractPancreatic cancer is a leading cause of cancer death due to its early metastasis and limited response to the current therapies. Metastasis is a complicated multistep process, which is determined by complex genetic alterations. Despite the identification of many metastasis-related genes, distinguishing the drivers from numerous passengers and establishing the causality in cancer pathophysiology remains challenging. Here, we established a high-throughput and piggyBac transposon-based genetic screening platform, which enables either reduced or increased expression of chromosomal genes near the incorporation site of the gene search vector cassette that contains a doxycycline-regulated promoter. Using this strategy, we identified YWHAZ as a key regulator of pancreatic cancer metastasis. We demonstrated that functional activation of Ywhaz by the gene search vector led to enhanced metastatic capability in mouse pancreatic cancer cells. The metastasis-promoting role of YWHAZ was further validated in human pancreatic cancer cells. Overexpression of YWHAZ resulted in more aggressive metastatic phenotypes in vitro and a shorter survival rate in vivo by modulating epithelial-to-mesenchymal transition. Hence, our study established a high-throughput screening method to investigate the functional relevance of novel genes and validated YWHAZ as a key regulator of pancreatic cancer metastasis.
The complete and fully-phased diploid genome of a male Han Chinese
Authors: Yang Chentao , Zhou Yang , Song Yanni , Wu Dongya , Zeng Yan , Nie Lei , Liu Panhong , Zhang Shilong , Chen Guangji , Xu Jinjin , Zhou Hongling , Zhou Long , Qian Xiaobo , Liu Chenlu , Tan Shangjin , Zhou Chengran , Dai Wei , Xu Mengyang , Qi Yanwei , Wang Xiaobo , Guo Lidong , Fan Guangyi , Wang Aijun , Deng Yuan , Zhang Yong , Jin Jiazheng , He Yunqiu , Guo Chunxue , Guo Guoji , Zhou Qing , Xu Xun , Yang Huanming , Wang Jian , Xu Shuhua , Mao Yafei , Jin Xin , Ruan Jue , Zhang Guojie 
Published: July 2023

AbstractSince the release of the complete human genome, the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity. Here, we present a fully phased and well-annotated diploid human genome from a Han Chinese male individual (CN1), in which the assemblies of both haploids achieve the telomere-to-telomere (T2T) level. Comparison of this diploid genome with the CHM13 haploid T2T genome revealed significant variations in the centromere. Outside the centromere, we discovered 11,413 structural variations, including numerous novel ones. We also detected thousands of CN1 alleles that have accumulated high substitution rates and a few that have been under positive selection in the East Asian population. Further, we found that CN1 outperforms CHM13 as a reference genome in mapping and variant calling for the East Asian population owing to the distinct structural variants of the two references. Comparison of SNP calling for a large cohort of 8869 Chinese genomes using CN1 and CHM13 as reference respectively showed that the reference bias profoundly impacts rare SNP calling, with nearly 2 million rare SNPs miss-called with different reference genomes. Finally, applying the CN1 as a reference, we discovered 5.80 Mb and 4.21 Mb putative introgression sequences from Neanderthal and Denisovan, respectively, including many East Asian specific ones undetected using CHM13 as the reference. Our analyses reveal the advances of using CN1 as a reference for population genomic studies and paleo-genomic studies. This complete genome will serve as an alternative reference for future genomic studies on the East Asian population.
X-linked intellectual disability related to a novel variant of KLHL15
Authors: Kido Jun , Egami Kimiyasu , Misumi Yohei , Sugawara Keishin , Tsuchida Naomi , Matsumoto Naomichi , Ueda Mitsuharu , Nakamura Kimitoshi 
Published: July 2023

AbstractKelch-like (KLHL) 15, localized on chromosome Xp22.11, was recently identified as an X-linked intellectual disability gene. Herein, we report a case of a male patient with a novel nonsense variant, c.736 C > T p.(Arg246*), in KLHL15, who presented with impaired intelligence, short stature, frequent hypoglycemia, and periodic fever. Patients with nonsense variants in KLHL15 may develop intellectual disabilities, minor skeletal anomalies, and facial dysmorphisms.
Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
Authors: Berquez Marine , Chen Zhiyong , Festa Beatrice Paola , Krohn Patrick , Keller Svenja Aline , Parolo Silvia , Korzinkin Mikhail , Gaponova Anna , Laczko Endre , Domenici Enrico , Devuyst Olivier , Luciani Alessandro 
Published: July 2023

AbstractDifferentiation is critical for cell fate decisions, but the signals involved remain unclear. The kidney proximal tubule (PT) cells reabsorb disulphide-rich proteins through endocytosis, generating cystine via lysosomal proteolysis. Here we report that defective cystine mobilization from lysosomes through cystinosin (CTNS), which is mutated in cystinosis, diverts PT cells towards growth and proliferation, disrupting their functions. Mechanistically, cystine storage stimulates Ragulator-Rag GTPase-dependent recruitment of mechanistic target of rapamycin complex 1 (mTORC1) and its constitutive activation. Re-introduction of CTNS restores nutrient-dependent regulation of mTORC1 in knockout cells, whereas cell-permeant analogues of L-cystine, accumulating within lysosomes, render wild-type cells resistant to nutrient withdrawal. Therapeutic mTORC1 inhibition corrects lysosome and differentiation downstream of cystine storage, and phenotypes in preclinical models of cystinosis. Thus, cystine serves as a lysosomal signal that tailors mTORC1 and metabolism to direct epithelial cell fate decisions. These results identify mechanisms and therapeutic targets for dysregulated homeostasis in cystinosis.
The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer
Authors: Zhou Wei , Wang Wenxi , Liang Yuxin , Jiang Ruibin , Qiu Fensheng , Shao Xiying , Liu Yang , Fang Le , Ni Maowei , Yu Chenhuan , Zhao Yue , Huang Weijia , Li Jiong , Donovan Michael J. , Wang Lina , Ni Juan , Wang Dachi , Fu Ting , Feng Jianguo , Wang Xiaojia , Tan Weihong , Fang Xiaohong 
Published: July 2023

AbstractKinase inhibitors against Cyclin Dependent Kinase 4 and 6 (CDK4/6i) are promising cancer therapeutic drugs. However, their effects are limited by primary or acquired resistance in virtually all tumor types. Here, we demonstrate that Leucine Rich Pentatricopeptide Repeat Containing (LRPPRC) controls CDK4/6i response in lung cancer by forming a feedback loop with CDK6. LRPPRC binds to CDK6-mRNA, increasing the stability and expression of CDK6. CDK6 and its downstream E2F Transcription Factor 1 (E2F1), bind to the LRPPRC promoter and elevate LRPPRC transcription. The activation of the LRPPRC-CDK6 loop facilitates cell cycle G1/S transition, oxidative phosphorylation, and cancer stem cell generation. Gossypol acetate (GAA), a gynecological medicine that has been repurposed as a degrader of LRPPRC, enhances the CDK4/6i sensitivity in vitro and in vivo. Our study reveals a mechanism responsible for CDK4/6i resistance and provides an enlightening approach to investigating the combinations of CDK4/6 and LRPPRC inhibitors in cancer therapy.
Instabilities of heavy magnons in an anisotropic magnet
Authors: Bai Xiaojian , Zhang Shang-Shun , Zhang Hao , Dun Zhiling , Phelan W. Adam , Garlea V. Ovidiu , Mourigal Martin , Batista Cristian D. 
Published: July 2023

AbstractThe search for new elementary particles is one of the most basic pursuits in physics, spanning from subatomic physics to quantum materials. Magnons are the ubiquitous elementary quasiparticle to describe the excitations of fully-ordered magnetic systems. But other possibilities exist, including fractional and multipolar excitations. Here, we demonstrate that strong quantum interactions exist between three flavors of elementary quasiparticles in the uniaxial spin-one magnet FeI2. Using neutron scattering in an applied magnetic field, we observe spontaneous decay between conventional and heavy magnons and the recombination of these quasiparticles into a super-heavy bound-state. Akin to other contemporary problems in quantum materials, the microscopic origin for unusual physics in FeI2is the quasi-flat nature of excitation bands and the presence of Kitaev anisotropic magnetic exchange interactions.
Association between cell-free DNA fetal fraction and pregnant character: a retrospective cohort study of 27,793 maternal plasmas
Authors: Hou Yaping , Yang Jiexia , Deng Fuli , Wang Fanghua , Peng Haishan , Guo Fangfang , Wang Dongmei , Yin Aihua 
Published: July 2023

AbstractTo determine the association between cell-free DNA fetal fraction (cffDNA) and various prenatal characters to better guide the clinical application of noninvasive prenatal screening (NIPS), a retrospective cohort study of 27,793 women with singleton pregnancies was conducted. Results indicated that no significant difference on cffDNA between trisomy/sex chromosome aneuploidy (SCA) and non-trisomy groups was found. However, the fetal fraction (FF) in the T18 and T13 subgroups were significantly lower than that in the non-trisomy group, while the FF in the T21 group was significantly higher than the non-trisomy group. Pearson’s correlation analysis revealed a positive correlation between √FF and gestational week in the T21, SCA, and non-trisomy groups. A negative correlation between maternal age and √FF in T21 and non-trisomy cases was found, but a positive correlation in SCA group. Compared to the decreasing trend in FF in the T21 group, no significant difference was observed in the SCA group. The √FF level was negatively correlated to maternal BMI in T21 and non-trisomy group, while a positive correlation in SCA group. FF was close related to the result of NIPS and related maternal factors. Though NIPS has increased accuracy, the complexity still should be recognized especially in clinical practice.
Gut dysbiosis in Thai intrahepatic cholangiocarcinoma and hepatocellular carcinoma
Authors: Pomyen Yotsawat , Chaisaingmongkol Jittiporn , Rabibhadana Siritida , Pupacdi Benjarath , Sripan Donlaporn , Chornkrathok Chidchanok , Budhu Anuradha , Budhisawasdi Vajarabhongsa , Lertprasertsuke Nirush , Chotirosniramit Anon , Pairojkul Chawalit , Auewarakul Chirayu U. , Ungtrakul Teerapat , Sricharunrat Thaniya , Phornphutkul Kannikar , Sangrajang Suleeporn , Loffredo Christopher A. , Harris Curtis C. , Mahidol Chulabhorn , Wang Xin Wei , Ruchirawat Mathuros ,   TIGER-LC Consortium
Published: July 2023

AbstractPrimary liver cancer (PLC), which includes intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC), has the highest incidence of all cancer types in Thailand. Known etiological factors, such as viral hepatitis and chronic liver disease do not fully account for the country’s unusually high incidence. However, the gut-liver axis, which contributes to carcinogenesis and disease progression, is influenced by the gut microbiome. To investigate this relationship, fecal matter from 44 Thai PLC patients and 76 healthy controls were subjected to whole-genome metagenomic shotgun sequencing and then analyzed by marker gene-based and assembly based methods. Results revealed greater gut microbiome heterogeneity in iCCA compared to HCC and healthy controls. Two Veillonella species were found to be more abundant in iCCA samples and could distinguish iCCA from HCC and healthy controls. Conversely, Ruminococcus gnavus was depleted in iCCA patients and could distinguish HCC from iCCA samples. High Veillonella genus counts in the iCCA group were associated with enriched amino acid biosynthesis and glycolysis pathways, while enriched phospholipid and thiamine metabolism pathways characterized the HCC group with high Blautia genus counts. These findings reveal distinct landscapes of gut dysbiosis among Thai iCCA and HCC patients and warrant further investigation as potential biomarkers.