bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Foreign Language Effect on Tolerance of Ambiguity
Authors: Purpuri Silvia , Vasta Nicola , Filippi Roberto , Wei Li , Mulatti Claudio 
Published: July 2023

AbstractPrevious research has shown that bilingual speakers may be more tolerant to ambiguity, they might perceive situations of ambiguity more interesting, challenging and desirable (e.g., Dewaele & Li, 2013). To our knowledge, no data are available addressing the question whether the language in use can have an effect on the personality trait of tolerance of ambiguity (ToA). This study investigated whether and how reading statements in a second language (L2), as opposed to the native language (L1), affects ToA. 387 Italian–English bilingual adults completed a questionnaire measuring levels of ToA either in English or Italian. Results revealed that processing information in L2 promoted higher scores of ToA overall and in sentences that were related to challenging perspectives and change. Age, gender and L2 proficiency were significant predictors of higher ToA scores. This study offers new evidence that processing information in a L2 can affect tolerance of ambiguous situations.
Pflegeentwicklung – So viel mehr als ein Fortbildungskatalog
Authors: Auerbach Thomas , Brüchmann Sabine 
Published: July 2023

Was ist zu diesem Thema bereits bekannt? In einer Studie „Personalentwicklung und Qualifizierung“ (Göpfert-Divivier & Ahr, 2003) wurde aufgezeigt, dass Interventionen und Modelle zur Wissensvermittlung mögliche Mittel für Personalbindung und -gewinnung sind. Wie wird eine neue Perspektive eingebracht? Durch Vermittlung von kollegialem Fachwissen, durch die Bearbeitung von Praxisbeispielen durch Studierende und durch pflegefachliche Einarbeitungsmodule für neue Pflegende, öffnen wir neue Perspektiven in der Pflege- und Personalentwicklung. Was sind die Auswirkungen für die Praxis? Mit der Einführung von drei Best Practice-Ideen wird ein breiter Fachwissenstransfer, eine Verbesserung des professionsübergreifenden Verständnisses und eine strukturierte Einarbeitung angeboten. Damit verbunden ist eine Verbesserung der Arbeitszufriedenheit und eine bessere Personalbindung.
Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms
Authors: Krystal John H. , Kavalali Ege T. , Monteggia Lisa M. 
Published: July 2023

AbstractKetamine is an open channel blocker of ionotropic glutamatergic N-Methyl-D-Aspartate (NMDA) receptors. The discovery of its rapid antidepressant effects in patients with depression and treatment-resistant depression fostered novel effective treatments for mood disorders. This discovery not only provided new insight into the neurobiology of mood disorders but also uncovered fundamental synaptic plasticity mechanisms that underlie its treatment. In this review, we discuss key clinical aspects of ketamine’s effect as a rapidly acting antidepressant, synaptic and circuit mechanisms underlying its action, as well as how these novel perspectives in clinical practice and synapse biology form a road map for future studies aimed at more effective treatments for neuropsychiatric disorders.
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder
Authors: Recourt Kasper , de Boer Peter , van der Ark Peter , Benes Heike , van Gerven Joop M. A. , Ceusters Marc , van Nueten Luc , Drevets Wayne C. , Bhatacharya Anindya , Browning Michael , Jacobs Gabriel E. 
Published: July 2023

AbstractJNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral interleukin (IL)-1β release, and attenuated dexamphetamine-induced improvements of mood and (visuo)motor performance in a human dexamphetamine-challenge paradigm. In depression, P2X7R inhibition may dampen immune-related dysregulation of mood. These results suggest that the impact of P2X7R inhibition is most prominent in situations where mood regulation is disrupted. Total sleep deprivation (TSD) results in an acute emotional perturbation, which yields a transient antidepressant effect. In the current study, TSD was applied as a behavioral challenge to investigate whether such effects could be modulated by JNJ-54175446. This was a double-blind, placebo-controlled, randomized study to assess the safety and pharmacokinetics of JNJ-54175446 and explore its effects in patients with single episode and recurrent major depressive disorder (MDD) (N = 69) and baseline total Inventory of Depressive Symptomatology Clinician Rated (IDS-C) > 30. Patients were randomized to receive JNJ-54175446 throughout the 10-day treatment period, placebo for days 1–3 followed by JNJ-54175446 or placebo throughout. All patients underwent 36 h of TSD starting on day three until the evening of day four. The early start group was hypothesized to experience a reduced effect from TSD whilst the late starting group was hypothesized to experience prolonged effects from the TSD. JNJ-54175446 was well-tolerated and adverse events were mild to moderate. JNJ-54175446 reduced IL-1β release by LPS-stimulated peripheral white blood cells in the presence of the P2X receptor agonist benzyl adenosine triphosphate (BzATP). JNJ-54175446 did not have a significant effect on mood as assessed using the Hamilton Depression Rating Scale, 17 items (HDRS17) and the Self-rated Quick Inventory of Depressive Symptoms (QIDS-SR). However, JNJ-54175446 blunted an acute reduction of anhedonia that occurred as a result of TSD, assessed by the Snaith-Hamilton Pleasure Scale (SHAPS) and the Probabilistic Instrumental Learning Task (PILT).
The emergence of RAS mutations in patients with RAS wild-type mCRC receiving cetuximab as first-line treatment: a noninterventional, uncontrolled multicenter study
Authors: Tsai Hsiang-Lin , Lin Chun-Chi , Sung Yung-Chung , Chen Shang-Hung , Chen Li-Tzong , Jiang Jeng-Kai , Wang Jaw-Yuan 
Published: July 2023

Absrtact
Background
Patients treated with anti-epidermal growth factor receptor (anti-EGFR) will ultimately develop acquired resistance promoted by clonal selection, mainly the emergence of mutations in the MAPK pathway (mostly RAS mutations). Baseline assessment of RAS mutations in the blood of patients correlates well with RAS tumour tissue testing and is currently an alternative option in routine clinical practice to guide first-line therapy. The aim of this study was the prevalence of acquired genomic alterations detected in the auxiliary tool of ctDNA testing and investigated the role of RAS ctDNA status for detecting tumour response and predicting benefit to anti-EGFR therapy.

Methods
Only patients with concordant wild-type formalin-fixed, paraffin-embedded (FFPE) tumour tissue and baseline ctDNA RAS wild-type were included. RAS mutations in plasma were evaluated using MassARRAY platform. Blood samples were collected at baseline, every 3 months during first-line treatment, and at disease progression. The primary endpoint was the detection rate of RAS mutations during cetuximab treatment. The correlation between response and survival outcomes and the emergence of circulating RAS mutations was also analysed.

Results
The detection rate of RAS mutations during treatment was 9.3% (10/108). RAS mutations detection occurred a median of 3 months prior to radiologic documentation. The subgroup of patients with RAS mutations exhibited significantly inferior progression-free survival and overall survival (P = 0.002 and 0.027, respectively) but the baseline characteristics, response rates, disease control rates, and metastatectomy were not significant (all P > 0.05).

Conclusions
We demonstrated that RAS ctDNA status might be a valuable biomarker for detecting early tumour response and predicting benefit to anti-EGFR therapy.
Clinical Trial Registration: NCT03401957 (January 17, 2018).
CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c in HCT116 colorectal cancer cells: comprehensive characterization after exposure to 5-FU reveals EMT and autophagy as key processes regulated by miR-34
Authors: Huang Zekai , Kaller Markus , Hermeking Heiko 
Published: July 2023

AbstractThe miR-34a and miR-34b/c encoding genes represent direct targets of the p53 transcription factor, and presumably mediate part of the tumor suppressive effects of p53. Here, we sought to determine their functional relevance by inactivating miR-34a and/or miR-34b/c using a CRISPR/Cas9 approach in the colorectal cancer (CRC) cell line HCT116. Concomitant deletion of miR-34a and miR-34b/c resulted in significantly reduced suppression of proliferation after p53 activation, enhanced migration, invasion and EMT, as well as reduced sensitivity to chemotherapeutics, increased stress-induced autophagic flux, decreased apoptosis and upregulation of autophagy-related genes after 5-FU treatment. However, inactivation of singular miR-34a or miR-34b/c had little effects on the aforementioned processes. RNA-Seq analysis revealed that concomitant deletion of miR-34a/b/c caused EMT signature enrichment, impaired gene repression by the p53-DREAM pathway and elevated autophagy after 5-FU treatment. A gene signature comprised of mRNAs significantly upregulated after combined inactivation of miR-34a and miR-34b/c showed a significant association with the invasive colon cancer subtype CMS4 and poor overall survival in two CRC patient cohorts, and with 5-FU resistance in CRC cell lines. In miR-34a/b/c-deficient cells the upregulated miR-34 target FOXM1 directly induced p62 and ATG9A, which increased autophagy and consequently attenuated apoptosis and rendered the miR-34a/b/c-KO cells more resistant to 5-FU. Inhibition of autophagy by depletion of ATG9A or chloroquine re-sensitized miR-34a/b/c-deficient HCT116 cells to 5-FU. In summary, our findings show a complementary role of miR-34a and miR-34b/c in the regulation of EMT and autophagy which may be relevant for CRC therapy in the future.
A burns and COVID-19 shared stress responding gene network deciphers CD1C-CD141- DCs as the key cellular components in septic prognosis
Authors: Liang Qiao , Wang Lei , Xu Jing , Lin Anqi , Wu Yongzheng , Tao Qing , Zhang Bin , Min Haiyan , Song Shiyu , Gao Qian 
Published: July 2023

AbstractDifferential body responses to various stresses, infectious or noninfectious, govern clinical outcomes ranging from asymptoma to death. However, the common molecular and cellular nature of the stress responsome across different stimuli is not described. In this study, we compared the expression behaviors between burns and COVID-19 infection by choosing the transcriptome of peripheral blood from related patients as the analytic target since the blood cells reflect the systemic landscape of immune status. To this end, we identified an immune co-stimulator (CD86)-centered network, named stress-response core (SRC), which was robustly co-expressed in burns and COVID-19. The enhancement of SRC genes (SRCs) expression indicated favorable prognosis and less severity in both conditions. An independent whole blood single-cell RNA sequencing of COVID-19 patients demonstrated that the monocyte-dendritic cell (Mono-DC) wing was the major cellular source of SRC, among which the higher expression of the SRCs in the monocyte was associated with the asymptomatic COVID-19 patients, while the quantity-restricted and function-defected CD1C-CD141-DCs were recognized as the key signature which linked to bad consequences. Specifically, the proportion of the CD1C-CD141-DCs and their SRCs expression were step-wise reduced along with worse clinic conditions while the subcluster of CD1C-CD141-DCs from the critical COVID-19 patients was characterized of IFN signaling quiescence, high mitochondrial metabolism and immune-communication inactivation. Thus, our study identified an expression-synchronized and function-focused gene network in Mono-DC population whose expression status was prognosis-related and might serve as a new target of diagnosis and therapy.
Prevalence of iodine deficiency among vegan compared to vegetarian and omnivore children in the Czech Republic: cross-sectional study
Authors: Světnička Martin , Heniková Marina , Selinger Eliška , Ouřadová Anna , Potočková Jana , Kuhn Tilman , Gojda Jan , El-Lababidi Eva 
Published: July 2023

Abstract
Background
The intake and homeostasis of iodine, an essential micronutrient that plays a vital role in thyroid physiology, is of particular concern with the increasing popularity of vegetarian (VG) and vegan (VN) diets. Children on these restrictive diets may be at risk of possible adverse effects on growth and development, but there is currently a lack of recent epidemiological studies on this topic.

Methods
We gathered clinical, anthropometric, and blood/urine data on iodine status and thyroid function from children aged 0–18 years who followed either a VG diet (n = 91), VN diet (n = 75), or omnivore diet (OM, n = 52). Cross-sectional comparison of the groups and linear regression was used. Stratified analyses were performed based on age (according to WHO): 0–5 years and 6–18 years.

Results
Our study revealed no significant differences in levels of thyroid-stimulating hormone (TSH), triiodothyronine (fT3), thyroglobulin (TG) or anti-thyroid peroxidase antibody (ATPOc) between the VG, VN, and OM groups. However, thyroxine (fT4) levels were found to be higher in the VN group compared to the OM group (15.00 ± 1.73 vs. 16.17 ± 1.82 pmol/l, p < 0.001). The presence of anti-thyroglobulin antibodies (AhTGc) was notably more common in the VG (18.2%)/VN (35.0%) groups than in the OM group (2.1%) (p < 0.001). Regarding iodine status, the concentration of iodine in spot urine (UIC) was found to be highest in the OM group (197.28 ± 105.35 vs. VG: 177.95 ± 155.88 vs. VN: 162.97 ± 164.51 µg/l, p < 0.001). Notably, the lowest (5.99 µg/l) and highest (991.80 µg/l) levels were measured in the VN group. Of the participants, 31 VN, 31 VG and 10 OM children met the criteria for iodine deficiency (i.e., UIC < 100 µg/l). We found that children with regular iodine supplementation had higher UIC (p < 0.001). Importantly, the median UIC was above 100 µg/l in all three groups, through the recommended intake (RDI) of iodine was rarely met throughout the groups.

Conclusion
We have observed a trend to lower UIC values in VN as compared to OM. This trend is also reflected in the median UIC values, even though the median UIC values were above the WHO cut-off (e.g., 100 µg/l) for iodine deficiency in all dietary groups. These results suggest that VN and VG children may be more at higher risk of iodine deficiency, this theory is also supported by higher prevalence of AhTGc positivity. Further research is needed to investigate the long-term impact of these dietary patterns on iodine status and thyroid function in children. Given our findings, it may also be necessary to consider new guidelines for supplementing children following VG and VN diets to ensure their iodine needs are met.
The anti-Alzheimer potential of novel spiroindolin-1,2-diazepine derivatives as targeted cholinesterase inhibitors with modified substituents
Authors: Pourtaher Hormoz , Hasaninejad Alireza , Zare Shahrokh , Tanideh Nader , Iraji Aida 
Published: July 2023

AbstractIn this study, a new series of spiro indolin-1,2-diazepine were designed, synthesized, and screened for their cholinesterase inhibitory activities. A novel, green, high-yielding approach was constructed to synthesize spiro indolin-1,2-diazepine derivatives through a cascade reaction of different isatins, malononitrile and 1,1-enediamines (EDAMs) via sequential four-component reactions to produce the target compounds with good to excellent yields. Next the inhibitory potencies of all derivatives were determined spectroscopically at 415 nm using the modified Ellman method. The results of the in vitro screening indicated that 5l with spiroindolin-1,2-diazepine core bearing 5-NO2 at R1 and 4-OH at R2 was the most potent and selective AChE inhibitor with an IC50 value of 3.98 ± 1.07 µM with no significant inhibition against BChE while 5j was the most active analog against both AChE and BChE enzymes. The structure–activity relationships suggested the variation in the inhibitory activities of derivatives was affected by different substitutions on the indolinone ring as well as the phenyl moiety. The enzyme kinetic studies of the most potent compound 5l at five different concentrations and acetylthiocholine substrate (0.1–1 mM) by Ellman's method revealed that it inhibited AChE in a mixed mode with a Ki of 0.044 μM. A molecular docking study was performed via induced fit docking protocol to predict the putative binding interaction. It was shown that the moieties used in the initial structure design play a fundamental role in interacting with the enzyme's binding site. Further, molecular dynamics simulations with the Schrödinger package were performed for 5l in a complex with AChE and revealed that compound 5l formed the stable complex with the enzyme. The MTT toxicity assessments against the neuroblastoma cell line were executed, and no toxicity was seen for 5l under the tested concentrations.
Managing retreat for sandy beach areas under sea level rise
Authors: Setter Renee O. , Han Rachael X. , Tavares Kammie-Dominique , Newfield Conrad , Terry Alice , Roberson Isabella M. , Tarui Nori , Coffman Makena 
Published: July 2023

AbstractSea level rise (SLR) is projected to impact approximately one billion people by 2100. For many coastal communities, retreat is the most viable long-term option due to exposure risk under SLR and increased coastal hazards. Our research analyzes the costs of retreating coastal development at an iconic beach in Hawaiʻi that is experiencing severe erosion. We assess three retreat approaches: all-at-once, threshold-based, and reactive. Utilizing detailed SLR modeling projected to the year 2100, we estimate the public and private costs of retreat approaches and the amount of increased beach area. We find an all-at-once approach is most costly but maintains the largest beach area over time. In contrast, a reactive approach has the lowest direct costs but offers the least beach area gained over time and incurs the greatest public safety and environmental risk. The threshold-based approach largely mitigates public safety and environmental risks while providing more beach area over time than the reactive approach with similar direct costs. We find that a threshold-based approach should be further explored as a SLR response for coastal communities to maintain their sandy beach areas. Our study informs coastal adaptation research and identifies a new framework to explore the financial costs alongside social and ecological values.
Acoustic and optoacoustic stimulations in auditory brainstem response test in salicylate induced tinnitus
Authors: Montazeri Katayoon , Farhadi Mohammad , Akbarnejad Zeinab , Asadpour Abdoreza , Majdabadi Abbas , Fekrazad Reza , Mahmoudian Saeid 
Published: July 2023

AbstractAs a common debilitating disorder worldwide, tinnitus requires objective assessment. In the auditory brainstem response (ABR) test, auditory potentials can be evoked by acoustic or optoacoustic (induced by laser light) stimulations. In order to use the ABR test in the objective assessment of tinnitus, in this study, acoustic ABR (aABR) and optoacoustic ABR (oABR) were compared in the control and tinnitus groups to determine the changes caused by sodium salicylate (SS)-induced tinnitus in rat. In both aABR and oABR, wave II was the most prominent waveform, and the amplitude of wave II evoked by oABR was significantly higher than that of aABR. Brainstem transmission time (BTT), which represents the time required for a neural stimulation to progress from the auditory nerve ending to the inferior colliculus, was significantly shorter in oABR. In the tinnitus group, there was a significant increase in the threshold of both ABRs and a significant decrease in the amplitude of wave II only in the oABR. Based on our findings, the ABR test has the potential to be used in the assessment of SS-induced tinnitus, but oABR has the advantages of producing more prominent waveforms and significantly reducing the amplitude of wave II in tinnitus.
Insights into modeling refractive index of ionic liquids using chemical structure-based machine learning methods
Authors: Esmaeili Ali , Hekmatmehr Hesamedin , Atashrouz Saeid , Madani Seyed Ali , Pourmahdi Maryam , Nedeljkovic Dragutin , Hemmati-Sarapardeh Abdolhossein , Mohaddespour Ahmad 
Published: July 2023

AbstractIonic liquids (ILs) have drawn much attention due to their extensive applications and environment-friendly nature. Refractive index prediction is valuable for ILs quality control and property characterization. This paper aims to predict refractive indices of pure ILs and identify factors influencing refractive index changes. Six chemical structure-based machine learning models called eXtreme Gradient Boosting (XGBoost), Light Gradient Boosting Machine (LightGBM), Categorical Boosting (CatBoost), Convolutional Neural Network (CNN), Adaptive Boosting-Decision Tree (Ada-DT), and Adaptive Boosting-Support Vector Machine (Ada-SVM) were developed to achieve this goal. An enormous dataset containing 6098 data points of 483 different ILs was exploited to train the machine learning models. Each data point’s chemical substructures, temperature, and wavelength were considered for the models’ inputs. Including wavelength as input is unprecedented among predictions done by machine learning methods. The results show that the best model was CatBoost, followed by XGBoost, LightGBM, Ada-DT, CNN, and Ada-SVM. The R2 and average absolute percent relative error (AAPRE) of the best model were 0.9973 and 0.0545, respectively. Comparing this study’s models with the literature shows two advantages regarding the dataset’s abundance and prediction accuracy. This study also reveals that the presence of the –F substructure in an ionic liquid has the most influence on its refractive index among all inputs. It was also found that the refractive index of imidazolium-based ILs increases with increasing alkyl chain length. In conclusion, chemical structure-based machine learning methods provide promising insights into predicting the refractive index of ILs in terms of accuracy and comprehensiveness.
Association between obesity and mortality in critically ill COVID-19 patients requiring invasive mechanical ventilation: a multicenter retrospective observational study
Authors: Shimoyama Keiichiro , Endo Akira , Shimazui Takashi , Tagami Takashi , Yamakawa Kazuma , Hayakawa Mineji , Ogura Takayuki , Hirayama Atsushi , Yasunaga Hideo , Oda Jun 
Published: July 2023

AbstractThis study aimed to determine whether obesity and disease outcomes are associated in patients with critically-ill coronavirus disease 2019 (COVID-19) requiring invasive mechanical ventilation (IMV). This retrospective observational study using Japanese multicenter registry data included COVID-19 patients who required IMV and were discharged between January and September 2020. The patients were divided into the obese (body mass index [BMI] ≥ 25 kg/m2) and nonobese (BMI < 25 kg/m2) groups. Logistic regression models were used to analyze the association between obesity and disease outcomes. The primary outcome was in-hospital mortality; the secondary outcome was venovenous extracorporeal membrane oxygenation (VV-ECMO) implementation. Altogether, 477 patients were enrolled (obese, n = 235, median BMI, 28.2 kg/m2; nonobese, n = 242, median BMI, 22.4 kg/m2). Obesity was significantly associated with lower in-hospital mortality in the unadjusted logistic regression model (odds ratio 0.63; 95% confidence interval, 0.42–0.97; p = 0.033), but not with mortality in the adjusted logistic regression model using age, sex, and Charlson Comorbidity Index as covariates (p = 0.564). Obesity was not associated with VV-ECMO implementation in both unadjusted and adjusted models (unadjusted, p = 0.074; adjusted, p = 0.695). Obesity was not associated with outcomes in COVID-19 patients requiring IMV. Obesity may not be a risk factor for poor outcomes in these patients.