bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant‐Derived Biomaterials and Their Potential in Cardiac Tissue Repair
Authors: Dai Yichen , Qiao Kai , Li Demin , Isingizwe Phocas , Liu Haohao , Liu Yu , Lim Khoon , Woodfield Tim , Liu Guozhen , Hu Jinming , Yuan Jie , Tang Junnan , Cui Xiaolin 
Published: March 2023

AbstractCardiovascular disease remains the leading cause of mortality worldwide. The inability of cardiac tissue to regenerate after an infarction results in scar tissue formation, leading to cardiac dysfunction. Therefore, cardiac repair has always been a popular research topic. Recent advances in tissue engineering and regenerative medicine offer promising solutions combining stem cells and biomaterials to construct tissue substitutes that could have functions similar to healthy cardiac tissue. Among these biomaterials, plant‐derived biomaterials show great promise in supporting cell growth due to their inherent biocompatibility, biodegradability, and mechanical stability. More importantly, plant‐derived materials have reduced immunogenic properties compared to popular animal‐derived materials (e.g., collagen and gelatin). In addition, they also offer improved wettability compared to synthetic materials. To date, limited literature is available to systemically summarize the progression of plant‐derived biomaterials in cardiac tissue repair. Herein, this paper highlights the most common plant‐derived biomaterials from both land and marine plants. The beneficial properties of these materials for tissue repair are further discussed. More importantly, the applications of plant‐derived biomaterials in cardiac tissue engineering, including tissue‐engineered scaffolds, bioink in 3D biofabrication, delivery vehicles, and bioactive molecules, are also summarized using the latest preclinical and clinical examples.
Multifunctional Antibacterial Nanonets Attenuate Inflammatory Responses through Selective Trapping of Endotoxins and Pro‐Inflammatory Cytokines
Authors: Tram Nhan Dai Thien , Tran Quy Thi Ngoc , Xu Jian , Su Jeannie Ching Ting , Liao Wupeng , Wong Wai Shiu Fred , Ee Pui Lai Rachel 
Published: March 2023

AbstractExtracellular lipopolysaccharide (LPS) released from bacteria cells can enter the bloodstream and cause septic complications with excessive host inflammatory responses. Target‐specific strategies to inactivate inflammation mediators have largely failed to improve the prognosis of septic patients in clinical trials. By utilizing their high density of positive charges, de novo designed peptide nanonets are shown to selectively entrap the negatively charged LPS and pro‐inflammatory cytokines tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6). This in turn enables the nanonets to suppress LPS‐induced cytokine production by murine macrophage cell line and rescue the antimicrobial activity of the last‐resort antibiotic, colistin, from LPS binding. Using an acute lung injury model in mice, it is demonstrated that intratracheal administration of the fibrillating peptides is effective at lowering local release of TNF‐α and IL‐6. Together with previously shown ability to simultaneously trap and kill pathogenic bacteria, the peptide nanonets display remarkable potential as a holistic, multifunctional anti‐infective, and anti‐septic biomaterial.
Injury Site Specific Xenon Delivered by Platelet Membrane‐Mimicking Hybrid Microbubbles to Protect Against Acute Kidney Injury via Inhibition of Cellular Senescence
Authors: Yang Jing , Chen Chaojin , Miao Xiaoyan , Wang Tienan , Guan Yu , Zhang Linan , Chen Sufang , Zhang Zheng , Xia Zhengyuan , Kang Jiayi , Li Haobo , Yin Tinghui , Hei Ziqing , Yao Weifeng 
Published: March 2023

AbstractInhalation of xenon gas improves acute kidney injury (AKI). However, xenon can only be delivered through inhalation, which causes non‐specific distribution and low bioavailability of xenon, thus limiting its clinical application. In this study, xenon is loaded into platelet membrane‐mimicking hybrid microbubbles (Xe‐Pla‐MBs). In ischemia‐reperfusion‐induced AKI, intravenously injected Xe‐Pla‐MBs adhere to the endothelial injury site in the kidney. Xe‐Pla‐MBs are then disrupted by ultrasound, and xenon is released to the injured site. This release of xenon reduced ischemia‐reperfusion‐induced renal fibrosis and improved renal function, which are associated with decreased protein expression of cellular senescence markers p53 and p16, as well as reduced beta‐galactosidase in renal tubular epithelial cells. Together, platelet membrane‐mimicking hybrid microbubble‐delivered xenon to the injred site protects against ischemia‐reperfusion‐induced AKI, which likely reduces renal senescence. Thus, the delivery of xenon by platelet membrane‐mimicking hybrid microbubbles is a potential therapeutic approach for AKI.
Intravascularly Deliverable Biomaterial Platforms for Tissue Repair and Regeneration Post‐Myocardial Infarction
Authors: Chen Alexander , Mesfin Joshua M. , Gianneschi Nathan C. , Christman Karen L. 
Published: March 2023

AbstractEach year, nearly 19 million people die of cardiovascular disease with coronary heart disease and myocardial infarction (MI) as the leading cause of the progression of heart failure. Due to the high risk associated with surgical procedures, a variety of minimally invasive therapeutics aimed at tissue repair and regeneration are being developed. While biomaterials delivered via intramyocardial injection have shown promise, there are challenges associated with delivery in acute MI. In contrast, intravascularly injectable biomaterials are a desirable category of therapeutics due to their ability to be delivered immediately post‐MI via less invasive methods. In addition to passive diffusion into the infarct, these biomaterials can be designed to target the molecular and cellular characteristics seen in MI pathophysiology, such as cells and proteins present in the ischemic myocardium, to reduce off‐target localization. These injectable materials can also be stimuli‐responsive through enzymes or chemical imbalances. This review outlines the natural and synthetic biomaterial designs that allow for retention and accumulation within the infarct via intravascular delivery, including intracoronary infusion and intravenous injection.
Space‐Confined Metal Ion Strategy for Carbon Materials Derived from Cobalt Benzimidazole Frameworks with High Desalination Performance in Simulated Seawater
Authors: Cao Shuai , Li Yong , Tang Yijian , Sun Yangyang , Li Wenting , Guo Xiaotian , Yang Feiyu , Zhang Guangxun , Zhou Huijie , Liu Zheng , Li Qing , Shakouri Mohsen , Pang Huan 
Published: March 2023

AbstractVarious metal ions with different valence states (Mg2+, Al3+, Ca2+, Ti4+, Mn2+, Fe3+, Ni2+, Zn2+, Pb2+, Ba2+, Ce4+) are successfully confined in quasi‐microcube shaped cobalt benzimidazole frameworks using a space‐confined synthesis strategy. More importantly, a series of derived carbon materials that confine metal ions are obtained by high‐temperature pyrolysis. Interestingly, the derived carbon materials exhibited electric double‐layer and pseudocapacitance properties because of the presence of metal ions with various valence states. Moreover, the presence of additional metal ions within carbon materials may create new phases, which can accelerate Na+ insertion/extraction and thus increase electrochemical adsorption. Density functional theory results showed that carbon materials in which Ti ions are confined exhibit enhanced insertion/extraction of Na+ resulting from the presence of the characteristic anatase crystalline phases of TiO2. The Ti‐containing materials have an impressive desalination capacity (62.8 mg g−1) in capacitive deionization (CDI) applications with high cycling stability. This work provides a facile synthetic strategy for the confinement of metal ions in metal–organic frameworks and thus supports the further development of derived carbon materials for seawater desalination by CDI.
Identifying the Internal Network Structure of a New Copper Isonicotinate Thin‐Film Polymorph Obtained via Chemical Vapor Deposition
Authors: Legenstein Lukas , Rodríguez‐Hermida Sabina , Rubio‐Giménez Víctor , Stassin Timothée , Hofer Sebastian , Kainz Manuel P. , Fratschko Mario , Carraro Francesco , Falcaro Paolo , Ameloot Rob , Resel Roland 
Published: March 2023

AbstractThe preparation of thin films is often associated with the appearance of unknown polymorphs, as both the substrate and deposition method can heavily influence crystallization processes. Here, chemical vapor deposition is used to obtain thin films of a copper‐isonicotinate (Cu‐INA) metal–organic framework (MOF). Starting from copper‐based precursor layers (copper oxide and hydroxide), a solid‐vapor conversion with vaporized isonicotinic acid in either a dry or humidified atmosphere, yields a new Cu‐INA MOF polymorph. It is found that the crystalline order of the precursor layer has a strong impact on the texture of Cu‐INA thin films. Furthermore, a novel methodology is introduced to determine the structure of a previously unknown thin‐film phase of Cu‐INA. Although only a few diffraction peaks are found via synchrotron grazing incidence X‐ray diffraction (GIXRD), a triclinic unit cell can be determined, and Patterson functions can be calculated. The latter reveals the position of the copper atoms within the unit cell and the alignment of the INA linkers defining the coordination network structure. This work introduces how the combination of GIXRD data with Patterson functions can be used to identify the structure of an unknown thin‐film MOF polymorph.
Synthesis of Chiral Diaryl Methanols via RuPHOX‐Ru Catalyzed Asymmetric Hydrogenation
Authors: Zhou Jiayu , Ye Jianxun , Zhang Yang , Li Zhaodi , Li Jingjing , Liu Delong , Zhang Wanbin 
Published: March 2023

AbstractThe RuPHOX‐Ru catalyzed asymmetric hydrogenation of diaryl ketones has been established, providing the corresponding chiral diaryl methanols in up to 99% yield and 99% ee. The protocol could be performed on a gram‐scale with a relatively low catalyst loading (2000 S/C) and the resulting products allow for several useful transformations, in particular for the synthesis of chiral drugs, such as, (S)‐Orphenadrine and (S)‐Neobenodine. Deuterium labeling and control experiments revealed that the RuPHOX‐Ru‐catalyzed asymmetric hydrogenation is fully subject to hydrogenation with H2 as the sole hydrogen source.magnified image
Functional Carbon from Nature: Biomass‐Derived Carbon Materials and the Recent Progress of Their Applications
Authors: He Hongzhe , Zhang Ruoqun , Zhang Pengcheng , Wang Ping , Chen Ning , Qian Binbin , Zhang Lian , Yu Jianglong , Dai Baiqian 
Published: March 2023

AbstractBiomass is considered as a promising source to fabricate functional carbon materials for its sustainability, low cost, and high carbon content. Biomass‐derived‐carbon materials (BCMs) have been a thriving research field. Novel structures, diverse synthesis methods, and versatile applications of BCMs have been reported. However, there has been no recent review of the numerous studies of different aspects of BCMs‐related research. Therefore, this paper presents a comprehensive review that summarizes the progress of BCMs related research. Herein, typical types of biomass used to prepare BCMs are introduced. Variable structures of BCMs are summarized as the performance and properties of BCMs are closely related to their structures. Representative synthesis strategies, including both their merits and drawbacks are reviewed comprehensively. Moreover, the influence of synthetic conditions on the structure of as‐prepared carbon products is discussed, providing important information for the rational design of the fabrication process of BCMs. Recent progress in versatile applications of BCMs based on their morphologies and physicochemical properties is reported. Finally, the remaining challenges of BCMs, are highlighted. Overall, this review provides a valuable overview of current knowledge and recent progress of BCMs, and it outlines directions for future research development of BCMs.
Engineering the MoS2/MXene Heterostructure for Precise and Noninvasive Diagnosis of Prostate Cancer with Clinical Specimens
Authors: Xie Shaowei , Fei Xiaochen , Wang Jiayi , Zhu Yi‐Cheng , Liu Jiazhou , Du Xinxing , Liu Xuesong , Dong Liang , Zhu Yinjie , Pan Jiahua , Dong Baijun , Sha Jianjun , Luo Yu , Sun Wenshe , Xue Wei 
Published: March 2023

AbstractHigh‐throughput metabolic fingerprinting has been deemed one of the most promising strategies for addressing the high false positive rate of prostate cancer (PCa) diagnosis in the prostate‐specific antigen (PSA) gray zone. However, the current metabolic fingerprinting remains challenging in achieving high‐precision metabolite detection in complex biological samples (e.g., serum and urine). Herein, a novel self‐assembly MoS2/MXene heterostructure nanocomposite with a tailored doping ratio of 10% is presented as a matrix for laser desorption ionization mass spectrometry analysis in clinical biosamples. Notably, owing to the two‐dimensional architecture and doping effect, MoS2/MXene demonstrates favorable laser desorption ionization performance with low adsorption energy, which is evidenced by efficient urinary metabolic fingerprinting with an enhanced area under curve (AUC) diagnosis capability of 0.959 relative to that of serum metabolic fingerprinting (AUC = 0.902) for the diagnosis of PCa in the PSA gray zone. Thus, this MoS2/MXene heterostructure is anticipated to offer a novel strategy to precisely and noninvasively diagnose PCa in the PSA gray zone.
Raman spectroscopic assessment of fibers and seeds of six cotton genotypes
Authors: He Zhongqi , Nam Sunghyun , Fang David 
Published: March 2023

AbstractRaman spectroscopy (RS) is a vibrational spectroscopy. This work reported the RS spectral characteristics of fiber and seed of six cotton (Gossypium sp.) genotypes differing in fiber length. While the RS spectra of fiber samples were dominated by the cellulose‐related peaks, the spectra of cottonseed samples were featured by the bands related to oil, protein, carbohydrate, and lignin components. Principal component analysis (PCA) revealed that the first two principal components (PCs) accounted for >87% of the total variation of the two types of samples. The PC1 versus PC2 plot classified the six fiber samples into three groups, but their cottonseeds into four groups. This experimental evidence implied the possibility of RS combined with PCA for rapid fiber phenotyping of cotton as well as for evaluating cottonseed nutrient information.
A density functional theory insight into the extraction mechanism of lithium recovery from alkaline brine by β‐diketones
Authors: Sun Qing , Chen Hang , Yu Jianguo 
Published: March 2023

AbstractIn this study, the mechanism of lithium extraction with β‐diketones was investigated by resolving the reaction mechanism, thermodynamic property, and molecular interaction through density functional theory approach. Before the selective extraction of lithium, the β‐diketones had tautomerism with the product of enol. The enol structure was unsteady in alkaline environment so that Li+can be selectively extracted by taking the place of hydroxyl hydrogen. Meanwhile, the synergistic effect of TOPO intensified the extraction ability by the generation of strong electrostatic. Based on the calculated Gibbs energy changes, the parameters of extraction efficiency and separation factor were analyzed and they had qualitative consistence with the experimental results. Meanwhile, it was determined that the electron‐withdrawing effect of the subsistent group in the β‐diketones had a critical influence on the extraction separation performance. Besides, the theoretical model predicted successfully the transition of extraction complex from hydrophilicity to lipophilicity after the combination with synergistic reagent.
Hydrogen bond induced acidic liquids for efficient biodiesel production
Authors: Zhou Zijing , Chen Xiaoyan , Worth John , Ye Changshen , Chen Jie , Qiu Ting 
Published: March 2023

AbstractIn chemical engineering, the Fischer–Speier esterification shows incredible value for biofuel production. However, the transformation suffers from challenges including necessary catalysts that cause corrosion issues in addition to a complex synthesis. Herein, we report a green acidic liquid, [N,N,N‐tris(propanesulfonic)aniline][ethanol]3, which is induced by hydrogen bonding interactions between a hydrogen bond acceptor (HBA) of [N,N,N‐tris(propanesulfonic)aniline] and three hydrogen bond donators (HBD) of ethanol, through a one‐step reaction. This liquid demonstrates strong Bronsted acidity and hydrogen bond networking to mimic ionic liquids (ILs) or deep‐eutectic solvents (DESs). Even under mild conditions, biodiesel was produced with 97.65% of esterification conversion. Exploiting distinguished molecular geometry with a singular methodology, made possible by contributions from HBD, allows for a further reaction of 1,3‐propanesulfonate with positively charged amines. This discovery is feasible with a wide range of HBDs as a solvent resulting more commercially accessible products owing to a much greener synthesis when compared with ILs and DESs.
H4C5 missense variant leads to a neurodevelopmental phenotype overlapping with Angelman syndrome
Authors: Borja Nicholas , Borjas‐Mendoza Paulo , Bivona Stephanie , Peart LéShon , Gonzalez Joanna , Johnson Brittney Keira , Guo Shengru , Yusupov Roman ,   Undiagnosed Diseases Network, Bademci Guney , Tekin Mustafa 
Published: March 2023

AbstractRecurrent de novo missense variants in H4 histone genes have recently been associated with a novel neurodevelopmental syndrome that is characterized by intellectual disability and developmental delay as well as more variable findings that include short stature, microcephaly, and facial dysmorphisms. A 4‐year‐old male with autism, developmental delay, microcephaly, and a happy demeanor underwent evaluation through the Undiagnosed Disease Network. He was clinically suspected to have Angelman syndrome; however, molecular testing was negative. Genome sequencing identified the H4 histone gene variant H4C5 NM_003545.4: c.295T>C, p.Tyr99His, which parental testing confirmed to be de novo. The variant met criteria for a likely pathogenic classification and is one of the seven known disease‐causing missense variants in H4C5. A comparison of our proband's findings to the initial description of the H4‐associated neurodevelopmental syndrome demonstrates that his phenotype closely matches the spectrum of those reported among the 29 affected individuals. As such, this report corroborates the delineation of neurodevelopmental syndrome caused by de novo missense H4 gene variants. Moreover, it suggests that cases of clinically suspected Angelman syndrome without molecular confirmation should undergo exome or genome sequencing, as novel neurodevelopmental syndromes with phenotypes overlapping with Angelman continue to be discovered.
Scope and Limitations in the Synthesis of Glucosamine‐based Ionic Liquids
Authors: Komabayashi Mirai , Okushiba Shoma , Nokami Toshiki , Jopp Stefan 
Published: March 2023

AbstractThis research article focuses on the synthesis of ionic liquids from glucosamine, a renewable material obtained from chitin. Our group previously experienced some obstacles in the synthesis of these glucosamine‐based ionic liquids, often due to the sterical hindrance induced by the dimethylated amino‐group. In this work we present a method using Borch reductive amination to overcome these limitations to achieve a dimethylethylamino‐group. We furthermore expanded upon the library of glucosamine‐based ionic liquids with new glycosidic groups, discovered a new shortened reaction procedure by skipping a deprotection step and finally compared the thermal properties of the ionic products to get an insight into structure‐property relationships.
An Iridium/Aluminum Cooperative Strategy for the β‐C(sp3)‐H Borylation of Saturated Cyclic Amines
Authors: Kuroda Yusuke , Park Kyungho , Shimazaki Yuto , Zhong Rong‐Lin , Sakaki Shigeyoshi , Nakao Yoshiaki 
Published: March 2023

AbstractDespite the widespread success in the functionalization of C(sp2)−H bonds, the deliberate functionalization of C(sp3)−H bonds in a highly site‐ and stereoselective manner remains a longstanding challenge. Herein, we report an iridium/aluminum cooperative catalytic system that enables the β‐selective C−H borylation of saturated cyclic amines and lactams. Furthermore, we have accomplished an enantioselective variant using binaphthol‐derived chiral aluminum catalysts to forge C−B bonds with high levels of stereocontrol. Computational studies suggest that the formation of a Lewis pair with the substrates is crucial to lower the energy of the transition state for the rate‐determining reductive elimination step.
Photoelectromagnetic Responsive Adaptive Porous Frameworks through Dynamic Covalent Chemistry of Tetraarylethylene‐backboned Aryldicyanomethyl Radicals
Authors: Wang Xinhao , Zhang Hui , Liu Haohao , Xu Gaoqiang , Lai Weiming , Zhang Yang , Ni Xinlong , Xie Sheng , Tang Ben Zhong , Zeng Zebing 
Published: March 2023

AbstractDynamic materials undergoing adaptive solid‐state transitions are attractive for soft mechanics and information technology. Here, we report a novel porous framework system based on macrocyclic trimers assembled from open‐shell tetraarylethylene building blocks with aryldicyanomethyl radicals as coupling linkers. Under mechanical, thermal, or chemical stimuli, the framework showed adaptability by activating conformational dynamics and radical‐based transformations, thus displaying macroscopic responsiveness in terms of light absorption, luminescence, and magnetism. We studied the dynamic processes by variable‐temperature nuclear magnetic resonance (VT‐NMR), variable‐temperature electron spin resonance (VT‐ESR), and superconducting quantum interference device (SQUID) measurement and further established a proof‐of‐concept application for multi‐modal information encryption. The strategy may open avenues for rational design of solid‐state photoelectromagnetic dynamic materials by merging dynamic covalent coupling chemistry and functional aggregation principles.
Photo‐RAFT Polymerization for Hydrogel Synthesis through Barriers and Development of Light‐Regulated Healable Hydrogels under NIR Irradiation
Authors: Wu Zilong , Zhang Tong , Shi Xiaobing , Corrigan Nathaniel , Ng Gervase , Boyer Cyrille 
Published: March 2023

AbstractWe report an aqueous and near‐infrared (NIR) light mediated photoinduced reversible addition–fragmentation chain transfer (photo‐RAFT) polymerization system catalyzed by tetrasulfonated zinc phthalocyanine (ZnPcS4−) in the presence of peroxides. Taking advantage of its fast polymerization rates and high oxygen tolerance, this system is successfully applied for the preparation of hydrogels. Exploiting the enhanced penetration of NIR light, photoinduced gelation is effectively performed through non‐transparent biological barriers. Notably, the RAFT agents embedded in these hydrogel networks can be reactivated on‐demand, enabling the hydrogel healing under NIR light irradiation. In contrast to the minimal healing capability (<15 %) of hydrogels prepared by free radical polymerization (FRP), RAFT‐mediated networks display more than 80 % recovery of tensile strength. Although healable polymer networks under UV and blue lights have already been established, this work is the first photochemistry system using NIR light, facilitating photoinduced healing of hydrogels through thick non‐transparent barriers.