bluuebunny/crossref_metadata_2025_split huggingface dataset:
On soft gluon resummation for associated single top production with a Higgs boson at the LHC
Authors: Kulesza Anna , Moreno Valero Laura , Theeuwes Vincent 
Published: February 2023

AbstractWe investigate threshold resummation of soft gluon corrections for the s-channel process of a single top quark production in association with a Higgs boson in the Standard Model. We choose to work in the three-particle invariant mass kinematics in direct QCD, i.e. in the space of Mellin moments. Our results take into account terms of up to next-to-leading logarithmic (NLL) precision, as well as $${\mathcal {O}} (\alpha _{\textrm{s}})$$

O
(

α
s

)

non-logarithmic terms which do not vanish at threshold. After presenting analytical expressions, we discuss the corresponding numerical results for the total cross section and the invariant mass distribution at the LHC.
Evaluation of the structure and electrical properties of (1−x)Bi0.5(Na0.80K0.20)0.5TiO3–xLiNbO3 ceramic composite for piezoelectric sensor applications
Authors: Athikesavan Venkatraj , Arulmani M. , Bhuvana S. 
Published: February 2023

Lead-free piezoceramics ([Formula: see text])Bi[Formula: see text](Na[Formula: see text]K[Formula: see text]TiO3–xLiNbO3 (BNKT–LN) (where [Formula: see text], 0.025, 0.050 and 0.075[Formula: see text]mol fraction) were examined for their ferroelectric stability and subsequent modifications. Traditional solid-state reaction techniques were used to create the BNKT–LN piezoceramics, which were then sintered at a temperature of 1200°C. We concentrated on the structural, dielectric, piezoelectric and ferroelectric properties of the BNKT–LN ceramics. The powder X-ray diffraction pattern revealed a single perovskite structure with no secondary phases, as was observed. The temperature-dependent dielectric curves demonstrated that the maximum dielectric constant ([Formula: see text]) is present in the pure BNKT sample and diffuses to a low value when the LN concentration rises. SEM confirms the material’s surface shape, and decreasing grain sizes are seen as the LN content rises. The BNKT–LN ceramics’ P–E hysteresis loops demonstrate good ferroelectric characteristics, with a maximum at 20 kV/cm. With an increase in LN concentration, remnant polarization ([Formula: see text]) and coercive field ([Formula: see text]) show a trend of increasing, reducing and then increasing. The maximum value of the piezoelectric coefficient ([Formula: see text]) for the combined samples was 147[Formula: see text]pC/N. As a result, the lead-free ceramic BNKT (BNKT–LN) doped with LN is an auspicious choice for piezoelectric sensor applications.
Non-Darcian Triple diffusive convection in a combined layer with heat source/sink
Authors: Gamaoun Fehmi , Manjunatha N. , Yellamma  , Sumithra R. , Kumar Raman , Prasannakumara B. C. 
Published: February 2023

In the presence of a constant heat source and sink in each layer, the Non-Darcian Triple Diffusive Convection (NDTDC) problem in a combined layer that is horizontally infinite is examined. This composite layer is rigid and adiabatic in the lower enclosure of the porous layer and free as well as isothermal in the higher enclosure of the fluid layer. The thermal Marangoni number (tMn) for two cases of thermal boundary combinations (TBCs), case (i) adiabatic–adiabatic and case (ii) adiabatic–isothermal, is determined by solving the system of ordinary differential equations obtained following normal mode analysis in closed form. The effect of important parameters on NDTDC is studied in detail and illustrated visually versus the thermal ratio. It is noticed that case (i) is observed to be stable because the Eigenvalue obtained is higher than that for case (ii) and NDTDC can be postponed by making the upper boundary of the combined layer adiabatic and the same is augmented by converting the upper boundary of the combined layer to isothermal, as isothermal boundaries support early convections.
IFRS Adoption Approaches and Accounting Quality
Authors: Agana Joseph Akadeagre , Zori Solomon George , Alon Anna 
Published: February 2023

SynopsisThe research problemThis paper sought to ascertain whether IFRS adoption approaches impact accounting quality. Specifically, as some countries utilize IFRS without modifications while others modify IFRS to suit their local context, we aimed to test whether these differences in IFRS adoption approaches have implications for accounting quality.MotivationPrior studies focused on the impact of IFRS adoption on accounting quality without considering the different approaches used by the adopting jurisdictions. Such differences affect the version of IFRS utilized at the country level. We refer to jurisdictions as adopters of IFRS when the IASB’s version of IFRS is utilized without modifications. In contrast, jurisdictions where the IFRS standards are modified at the national or regional level are called adapters. We also recognize the role of enforcement; thus, we first examined whether IFRS adoption and enforcement influence accounting quality. Second, we compared the accounting quality for adopters and adapters of the standards.The test hypothesesOur first hypothesis is that the quality of enforcement has a stronger effect on accounting quality than the adoption of IFRS. Second, adapters will have higher accounting quality than adopters of IFRS.Target populationWe focused on the reporting of companies in African countries. These jurisdictions have not been sufficiently examined in prior studies.Adopted methodologyWe use panel data estimation, specifically, random-effects model.AnalysesWe examined accounting quality for pre- and post-IFRS reporting based on 3946 firm-year observations from six African countries over 18 years. Our analysis of the adoption approach is based on 3736 firm-year observations for companies utilizing IFRS. Except for Egypt, which used a modified version of IFRS, other countries in our sample utilized the IASB’s version of IFRS. Using various standard metrics for accounting quality (earnings management, timely loss recognition, and value relevance), we ascertained whether adaption is associated with higher accounting quality compared to adoption.FindingsThe results indicate that IFRS adoption and enforcement proxy are not associated with accounting quality, but other institutional factors are. Adoption of the standards is less important for accounting quality than the existing institutions. With regard to the adoption approach used, adopters demonstrated higher accounting quality for accounting-based measures, less income smoothing, and more timely loss recognition than the adapters. The adopters also exhibited greater value relevance, which suggests that their reporting was better able to capture information that affects firm value. The adoption approaches may influence different dimensions of accounting quality, and the resulting differences are important for users, companies, and standard setters to consider.
WEAPONIZING THE COVID-19 VACCINE: THE GEOPOLITICAL STRUGGLE
Authors: PELZMAN JOSEPH , BAZEL-SHOHAM OFRA 
Published: February 2023

As the world continues to navigate a global pandemic that ignores national borders, it is not surprising to find a divide between the interests of vaccine-producing countries — and their entire supply chain networks for intermediates and raw materials — and countries that are primarily reliant on these producers for their vaccine consumption. This paper puts this debate in the context of a multi country strategic game where the major players have been able to produce a vaccine for COVID-19 and control the distribution of the vaccine and all its components. To address this issue of sovereign players, some have raised the possibility of a GATT/WTO intervention into COVID-19 vaccine sale and distribution. In addition, a legal battle is taking shape over lucrative patent rights for COVID-19 vaccines, with drug companies pitted against each other and government and academic scientists over who invented what. At the heart of the disputes is the billion-dollar question: Who can claim to have invented important elements of the COVID-19 vaccines? In June 2022, the WTO struck deals on a partial patent waiver for COVID-19 vaccines. Most observers believe that this change to the intellectual property rules will have limited impact on actual production for now because a current surplus of vaccines globally means there is little demand among vaccine makers to increase output. The implications are clear. The WTO compromise has allowed the existence of high hurdles for exports of products made under such a license. Given the limited WTO compromise agreement there are several options available to solve the problem of lack of access to the COVID-19 vaccine consuming nations at this stage. First, the US Supreme Court could invalidate each of the pharmaceutical companies’ patent requests. Second, individuals could file legal actions designed to disgorge the monopoly revenue of these pharmaceutical companies. If no legal action is taken, along these lines, and the WTO compromise is insufficient to solve the COVID-19 vaccine shortages in the developing world, then the developed countries will be opening the gate to PRC delivery of their COVID-19 vaccine to the entire developing and emerging markets.
Impact of Cannabis Seed Incorporation in Layer Diet on Productive Performance and Egg Quality Traits
Authors: Taaifi Yassine , Belhaj Kamal , Mansouri Farid , Rbah Youssef , Elbouanani Najlae , Melhaoui Reda , Ben Moumen Abdesamad , Azeroual Embarek , Serghini-Caid Hana , Elamrani Ahmed 
Published: February 2023

The production of nonindustrial cannabis is highly developed in the Moroccan Rif region; however, local farmers consider hemp seeds which are rich in omega 3 and tocopherols, only as by-products of cannabis cultivation with low market value. The local ecotype is considered to be a plant with a cannabinoid content of more than 0.4%. So, the objective of this research is to investigate how the incorporation of this local hemp seed affects productive performance and egg quality traits. The experiment is conducted to evaluate the effects of hemp seed (HS) incorporation on hen laying performance and physical egg quality at three levels: 10% (HS-10% group), 20% (HS-20% group), and 30% (HS-30% group). Ninety-six Lohmann Brown classic laying hens were randomly assigned to a control group and three feed treatments. The sampling was taken after the 28-week rearing period (peak egg laying). Throughout the experiment, low-rate HS inclusion (HS-10%) showed no significant differences in egg-laying performance (

p

> 0.05). However, the high incorporation rates of HS (20% and 30%) negatively affected the egg-laying performance (84–94% and 80–86%, respectively). The albumen quality was also improved by the HS inclusion, where the highest values of the Haugh unit were recorded, ranging between 68.69 and 73.91 for the HS-30% groups. The results also show that HS inclusion and duration influence significantly the yolk color (

p

< 0.001). The yellow intensity decreases with HS incorporation and aging, from a dark yellow (

b

∗

= 38.63 for the control group) to a very pale yellow (

b

∗

= 26.29 for HS 30% group). Based on these findings, we can conclude that the incorporation of nonindustrial Moroccan cannabis seeds (ecotype Beldiya) at low rate in the diet of laying hens does not alter the laying performance or the quality of the egg; therefore, they could be used in poultry feeding as an alternative constituent to partially replace high-cost imported ingredients, such as corn and soybeans.
RBM10 Loss Promotes EGFR-Driven Lung Cancer and Confers Sensitivity to Spliceosome Inhibition
Authors: Bao Yufang , Zhang Sirui , Zhang Xiaoyu , Pan Yunjian , Yan Yueren , Wang Ning , Ren Yunpeng , Zuo Ji , Zong Wei-Xing , Wang Zefeng , Wang Yongbo 
Published: February 2023

Abstract

In lung adenocarcinoma (LUAD), loss-of-function mutations in the splicing factor RBM10 frequently co-occur with oncogenic EGFR mutations. A detailed understanding of the functional consequences and therapeutic impact of RBM10 loss in EGFR-mutant LUAD could help identify more effective treatment strategies. Here, analysis of LUAD data sets indicated that RBM10 mutations are mutually exclusive with mutations in the tumor suppressor gene TP53. In an EGFR-driven LUAD mouse model, lung-specific ablation of either Rbm10 or Trp53 similarly promoted tumor development, leading to overlapping gene expression changes enriched in cancer-related pathways. RBM10 loss induced key RNA splicing changes concordant in mice and LUAD patients. Importantly, RBM10 deficiency conferred high sensitivity to spliceosome inhibition in EGFR-mutated LUAD cells. Combined treatment with spliceosome inhibitor improved the therapeutic efficacy of EGFR tyrosine kinase inhibitor osimertinib and overcame drug resistance, especially in RBM10-deficient LUAD. Together, this study establishes RBM10 as a tumor suppressor akin to p53 and provides a therapeutic strategy of targeting the splicing machinery in EGFR-driven LUAD.

Significance:
Loss of the splicing factor RBM10 is mutually exclusive with p53 mutations, promotes tumorigenesis, and enhances the efficacy of spliceosome inhibition in EGFR-driven lung cancer.
Phase II Study of Palbociclib (PD-0332991) inCCND1,2, or3Amplification: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1B
Authors: Clark Amy S. , Hong Fangxin , Finn Richard S. , DeMichele Angela M. , Mitchell Edith P. , Zwiebel James , Arnaldez Fernanda I. , Gray Robert J. , Wang Victoria , McShane Lisa M. , Rubinstein Larry V. , Patton David , Williams P. Mickey , Hamilton Stanley R. , Copur Mehmet S. , Kasbari Samer S. , Thind Ravneet , Conley Barbara A. , Arteaga Carlos L. , O'Dwyer Peter J. , Harris Lyndsay N. , Chen Alice P. , Flaherty Keith T. 
Published: February 2023

AbstractPurpose:Cyclin D/CDK4/6 is critical in controlling the G1 to S checkpoint. CCND, the gene encoding cyclin D, is known to be amplified in a variety of solid tumors. Palbociclib is an oral CDK4/6 inhibitor, approved in advanced breast cancer in combination with endocrine therapy. We explored the efficacy of palbociclib in patients with nonbreast solid tumors containing an amplification in CCND1, 2, or 3.Patients and Methods:Patients with tumors containing a CCND1, 2, or 3 amplification and expression of the retinoblastoma protein were assigned to subprotocol Z1B and received palbociclib 125 mg once daily for 21 days of a 28-day cycle. Tumor response was assessed every two cycles.Results:Forty patients were assigned to subprotocol Z1B; 4 patients had outside assays identifying the CCND1, 2, or 3 amplification and were not confirmed centrally; 3 were ineligible and 2 were not treated (1 untreated patient was also ineligible), leaving 32 evaluable patients for this analysis. There were no partial responses; 12 patients (37.5%) had stable disease as best response. There were seven deaths on study, all during cycle 1 and attributable to disease progression. Median progression-free survival was 1.8 months. The most common toxicities were leukopenia (n = 21, 55%) and neutropenia (n = 19, 50%); neutropenia was the most common grade 3/4 event (n = 12, 32%).Conclusions:Palbociclib was not effective at treating nonbreast solid tumors with a CCND1, 2, or 3 amplification in this cohort. These data do not support further investigation of single-agent palbociclib in tumors with CCND1, 2, or 3 amplification.
Precision Oncology: 2022 in Review
Authors: Rosen Ezra , Drilon Alexander , Chakravarty Debyani 
Published: February 2023

Summary:This article presents a review of the major advances and future implications in precision oncology accomplished in 2022 and centers on three primary pillars: advances in (i) rational drug design, (ii) study design, and (iii) novel biomarkers.
Ethical challenges in caring for healthy older adults: Qualitative perspectives
Authors: Zendehtalab Hamidreza , Vanaki Zohreh , Memarian Robabeh 
Published: February 2023

Background Healthy aging is one of the essential aspects of a health promotion program in the elderly. Aim Exploring ethical challenges in healthy elderly care from the perspective of nurses, older adults, and families in the Iranian context. Research Design This qualitative study was conducted using a content analysis approach in 4 health centers in northeastern Iran from 2017 to 2019. Semi-structured interviews, observation, review of elderly files, and focus groups were used to collect data. Ethical considerations The ethics committee of the university approved this study in Iran. This study adhered to the principles of the Helsinki Declaration. Ethical principles autonomy, confidentiality, and anonymity were considered for the participants. Participants were informed about the purpose of the study and submitted written informed consent regarding their participation. Findings The central theme was: An unfair approach to caring for healthy older adults. The three categories were as follows: Forgotten human care, disrespect, and lack of a meaningful and trustworthy relationship. The 14 subcategories highlighted the ethical challenges of healthy aging care in health centers. Discussion The findings showed that due to nurses’ unfamiliarity with the concept of healthy aging, older adults are discriminated against in care centers. Creating a standard care program for healthy older adults ensures that ethical principles are followed for these clients. Conclusion Various individual and organizational factors lead to an unfair approach to caring for healthy elderly in health centers. The following factors can help improve the care of healthy aging and reduce ethical challenges in this area: Introducing nurses to the concept of healthy old age and its dimensions, creating a community-based approach in health centers, prioritizing health issues over health issues, Involvement of families and older adults in needs assessment-goal setting-implementation and evaluation of health services, and design of home visit programs to provide services to healthy elderly.
Exploring Roles of Stakeholders in Combating Substance Abuse in the DIMAMO Surveillance Site, South Africa
Authors: Muthelo Livhuwani , Mbombi Masenyani Oupa , Mphekgwana Peter , Mabila Linneth Nkateko , Dhau Inos , Tlouyamma Joseph , Nemuramba Rathani , Mashaba Reneilwe Given , Mothapo Katlego , Ntimana Cairo Bruce , Maimela Eric 
Published: February 2023

Background: The increasing prevalence of substance abuse in rural areas of Limpopo Province is a concern for most stakeholders including the families, South Africa Police Service, and social workers. Combating Substance Abuse requires the active roles of various stakeholders in the rural community, due to limited resources for prevention, treatment, and recovery. Purpose: To report on the roles of stakeholders in tackling Substance Abuse during the awareness campaign conducted in the deep rural community of Limpopo Province, DIMAMO surveillance area. Methods: Qualitative narrative design was adopted to explore the roles of stakeholders in combating Substance Abuse during the awareness campaign conducted in the deep rural community. The population consisted of different stakeholders who play an active role in reducing Substance Abuse. The triangulation method was used for data collection (interviews, observations, and taking field notes during presentations). Purposive sampling was used to select all the available stakeholders who actively combat substance abuse in the communities. Thematic narrative analysis was used to analyze the interviews conducted with and content presented by the stakeholders to generate the themes. Results: The prevalence of Substance Abuse among the youth in the Dikgale community is high with a growing trend of Crystal Meth, “nyaope,” and Cannabis(marijuana). The prevalence is worsened by the diverse challenges experienced by the families and stakeholders which impact the strategies targeted to combat Substance Abuse. Conclusion: The findings indicated the need for strong collaborations among the stakeholders (including school leadership) to successfully combat Substance Abuse in rural areas. The findings demonstrated a need for a well-capacitated healthcare services with adequate rehabilitation centers and well-trained healthcare providers for combating Substance Abuse to minimize victim stigmatization.
The Short Graft ACL Reconstruction
Authors: Dave Lee Yee Han 
Published: February 2023

The Short Graft Anterior Cruciate Ligament (ACL) reconstruction is increasing in popularity. Surgeons are making use of autograft lengths of between 6-6.5 cm for ACL reconstruction. The grafts of choice are the hamstring and quadriceps tendon autograft. The grafts are prepared with cortical fixation on both the femur and tibia ends for cortical fixation. Short tunnels or sockets are reamed instead of full bone tunnels. This helps with bone preservation and the patients have less postoperative pain; but will require special instrumentation for retrograde drilling. The benefit of this technique is improved postoperative hamstring strength with the gracilis preserved, as only the semitendinosus tendon is harvested to obtain a quadrupled ACL graft. The outcomes of short graft ACL reconstruction are comparable to established transportal ACL reconstruction techniques. However, there is a learning curve and additional implant costs involved. The familiarity with the surgical technique, understanding of optimal graft fixation and biology are all paramount to success of this surgery.
How to Optimize Return to Sport in ACL Surgery
Authors: Albar Husnul Fuad 
Published: February 2023

Anterior cruciate ligament (ACL) rupture is one of the most common sport injuries. The incidence of ACL rupture was estimated to range from 30 to 78 per 100.000 person-years. Several sport contact injuries were reported that highly associated with ACL rupture, such as football (15%) and soccer (5.2%) competition. ACL rupture was also found more common in male than female players. The anatomy of ACL originates from lateral wall of the intercondylar fossa and inserts to the tibial eminence anteriorly. It comprises of two bundles, such as anteromedial and posterolateral bundle. The femoral attachment arises from resident’s ridge to the posterior articular margin of the lateral femoral condyle. The tibial attachment is closely related to the attachment of the lateral meniscus. Return to sport (RTS) remains to be the main goal of ACL reconstruction (ACLR). However, RTS criteria remains debatable due to differences outcome measure. RTS was noted 60-80% in different sports following ACL reconstruction surgery. However, there was several factors that may affect the ACLR surgery. Concomitant ligamentous and meniscus injury may prolong the RTS. Graft choice may also contribute to the process of RTS. Bone-patellar-tendon-bone (BPTB) graft has shown to have early incorporation to the femoral and tibial tunnel due to bone-to-bone healing. Surgical technique also plays role in the early RTS. Single-bundle and double-bundle ACL reconstruction remains debatable in ACLR surgery. However, there was no differences in both surgical techniques in terms of early RTS.