bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental Regulation and Industrial Green Transformation in the Yangtze River Economic Zone --- A Perspective Based on Emission Heterogeneity
Authors: Liying Liying Li , Weihong Zhang 
Published: March 2023

Abstract
Accelerating the green transformation of industry is the way to promote the comprehensive green and low-carbon development of the Yangtze River Economic Zone. The results show that there is a positive effect of environmental regulation on the green transformation of industry in the Yangtze River Economic Zone, which is consistent with the "Porter hypothesis", and the heterogeneity of the effect of environmental regulation on the green transformation of industry in the Yangtze River Economic Zone. In addition, the green development strategy of the Yangtze River Economic Belt implemented since 2016 has effectively enhanced the role of environmental regulations in promoting the green transformation of industries in the Yangtze River Economic Belt. In general, the intensity of environmental regulations in the Yangtze River Economic Belt is low, and the policy effects have not been fully exploited. To further promote the green transformation of industries in the Yangtze River Economic Zone, we should take the characteristics of emission heterogeneity as an important reference, formulate targeted environmental regulation policies by classification and zoning, accelerate the construction of a regional consultation mechanism for environmental regulation, and promote the continuous enrichment and dynamic optimization of environmental regulation policies.
Vital dye lymphoscintigraphy: An answer to decision making between single or two-stage laparoscopic Fowler-Stephens orchidopexy intraoperatively
Authors: Nandan Ruchira , Kumar Deepak , Pandey Vaibhav , Kumar Ishan , Kulkarni Paresh 
Published: March 2023

Abstract
Introduction
We hypothesized that vital dye lymphoscintigraphy (VDL) can be used to assess the testicular supply via vessel to vas and can be used to decide whether to go for single-stage Fowler-Stephens (FS1) or two-staged Fowler-Stephens (FS2) orchidopexy. We aimed to compare the clinical outcomes of FS1 and FS2 orchidopexy and to assess the role of the VDL technique.
Methods
A prospective study was done to include patients with high intraabdominal testis. They were subjected to the study protocol. During laparoscopic FS orchidopexy, VDL was performed. Around 0.5ml subcapsular injection of methylene blue was administered in the testis. The flow of methylene blue was observed and categorized as definitive, intermediate, or no flow along the vas for 10 mins. Testicular volume, testicular atrophy index, and hormonal response were studied and compared between the two groups. The post-operative relative testis atrophy percentage was calculated.
Result
The outcome of FS1 and FS2 orchidopexy was similar in terms of testicular volume, testicular atrophy index, and hormonal response. On VDL, 6 patients had no flow, of which 2 had FS1 and 4 FS2. The two patients who had no flow on VDL and had FS1, both developed testicular atrophy post-operatively. The four patients who had no flow on VDL and had FS2, none had testicular atrophy.
Conclusion
The outcome of FS1 and FS2 orchidopexy was similar. VDL can be used intraoperatively for deciding between the FS1 and FS2 orchidopexy. If VDL is added for intraoperative vascularity assessment, FS1 can be used as standard treatment for high intraabdominal testis.
Modified axial pullout resistance factors of geostrip and metal strip reinforcements in sand considering transverse pull effects
Authors: Karnamprabhakara Bhargav Kumar , Chennarapu Hariprasad , Balunaini Umashankar 
Published: March 2023

Abstract
The pullout resistance of reinforcement is an important parameter in the design of reinforced retaining structures. At incipient failure, the kinematics of failure in a reinforced retaining structure shows that the sliding mass of soil pulls the reinforcement obliquely along the slip surface. The response of reinforcement to oblique pull can be considered to be made up of equivalent axial and transverse components of the oblique pull. Accordingly, axial and transverse pullout tests were conducted on geostrip, and metal strip (both smooth and ribbed) reinforcements embedded in uniform sand. Ribbed metal strip reinforcement registered higher pullout resistance than smooth metal strip and geostrip reinforcements. The modified axial pullout resistance factors accounting for transverse pull ranged from 0.44 to 1.23, 1.4 to 3.5, and 2.0 to 5.2 for geostrip, smooth-metal-strip, and ribbed-metal-strip reinforcements, respectively. While the axial pullout resistance factors ranged from 0.34 to 0.65, 0.75 to 1.1, and 0.94 to 1.3.
Enhanced electrochemical supercapacitors from the metal silicates by multi-step treatment of natural green algaes
Authors: Zhang Shaoqing , Lu Yueyue , Shi Danjiao , Yao Yue , Wang Xuchun , Meng Changgong 
Published: March 2023

Abstract

Metal-silicates (Zn, Mn, Ni and Co) were prepared from natural green algaes (GAs) as supercapacitor electrodes. In this study, multi-step treatment with two kinds of porogenes was used to produce larger specific surface area and more abundant hierarchical pores. Firstly, GAs was treated with 1.0 M NaCl solution, then metal-silicates were prepared by the GAs using hydrothermal reaction. Lastly, the as-synthesized samples were soaked in 3.0 M NaOH solution to obtain the products (m-C-MSi, M = Zn, Mn, Ni and Co). Compared with the samples without multi-step treatment, the electrodes in this study exhibit much better electrochemical performance both as electrodes and as HSCs. This work proved that the multi-step treatment with porogenes is an effective method to enhance the electrochemical performance of the metal-silicate supercapacitors.
De-identification technique with facial deformation in head CT images
Authors: Uchida Tatsuya , Kin Taichi , Saito Toki , Shono Naoyuki , Kiyofuji Satoshi , Koike Tsukasa , Sato Katsuya , Niwa Ryoko , Takashima Ikumi , Kawahara Takuya , Oyama Hiroshi , Saito Nobuhito 
Published: March 2023

Abstract
Head CT, which includes the facial region, can visualize faces using 3D reconstruction, raising concern that individuals may be identified. We developed a new de-identification technique that distorts the faces of head CT images. Head CT images that were distorted were labeled as "original images" and the others as "reference images." Reconstructed face models of both were created, with 400 control points on the facial surfaces. All voxel positions in the original image were moved and deformed according to the deformation vectors required to move to corresponding control points on the reference image. Three face detection and identification programs were used to determine face detection rates and match confidence scores. Intracranial volume equivalence tests were performed before and after deformation, and correlation coefficients between intracranial pixel value histograms were calculated. Output accuracy of the deep learning model for intracranial segmentation was determined using Dice Similarity Coefficient before and after deformation. The face detection rate was 100%, and match confidence scores were < 90. Equivalence testing of the intracranial volume revealed statistical equivalence before and after deformation. The median correlation coefficient between intracranial pixel value histograms before and after deformation was 0.9965, indicating high similarity. Dice Similarity Coefficient values of original and deformed images were statistically equivalent. We developed a technique to de-identify head CT images while maintaining the accuracy of deep-learning models. The technique involves deforming images to prevent face identification, with minimal changes to the original information.
Hepatic Arterial Infusion Chemotherapy Combined with Tyrosine Kinase Inhibitors and PD-1 Inhibitors in Hepatocellular Carcinoma
Authors: Yu Bingran , Zhang Ning , Feng Yun , Zhang Yongfa , Zhang Ti , Wang Lu 
Published: March 2023

Abstract
Purposes: To compare the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) combined with tyrosine kinase inhibitors (TKIs) and anti-programmed cell death protein-1 (PD-1) immunotherapy versus combination therapy of transarterial chemotherapy (TACE), TKIs and PD-1 inhibitors in the treatment for hepatocellular carcinoma (HCC).
Methods: The data of 302 patients with HCC receiving HAIC combined with TKIs and PD-1 inhibitors (HAIC-TP group) and 446 patients receiving TACE combined with TKIs and PD-1 inhibitors (TACE-TP group) were retrospectively collected. The progression-free survival (PFS), overall survival (OS), tumor response and adverse events were compared between two groups. Propensity-score matching (PSM) analysis were utilized to minimize the bias.
Results: HAIC-TP group exhibited longer PFS (17.1 months versus 8.9 months, P < 0.001), longer OS (not reached versus 14.3 months, P < 0.001) and better objective response rate (RECIST: 33.1% versus 7.8%, P < 0.001; mRECIST: 51.4% versus 17.5%, P < 0.001) than TACE-TP group. Nausea, diarrhea and abdominal pain were more frequent in the HAIC-TP group, while liver dysfunction occurred more common in the TACE-TP group. PSM analysis showed the same results.
Conclusions: In patients with HCC, the combination of HAIC with TKIs and anti-PD-1 immunotherapy is an effective and safe therapeutic regimen over TACE-based combination therapy. A prospective study with a large sample size is needed to validate the efficacy and safety of the combination therapy.
The effect of environmental change on the long-term outcome of common mental disorders
Authors: Tyrer Peter , Duggan Conor , Yang Min , Tyrer Helen 
Published: March 2023

Abstract
Purpose

To examine the nature of positive and negative environmental change on clinical outcome in 210 patients presenting with anxiety and depression and followed up over 30 years.

Methods

In addition to clinical assessments, major environmental changes, particularly after 12 and 30 years, were recorded in all patients by a combination of self-report and taped interviews. Environmental changes were separated into two major groups, positive or negative, determined by patient opinion.

Results

Using a combined measure of clinical and social outcomes positive and negative environmental changes were compared. Positive changes were more likely than negative ones to be associated with a good outcome at 12 and 30 years (39% v 3.6% and 30.2% v 9.1% respectively). Similar greater improvement in accommodation (P = 0.009), relationships (P = 0.007), and substance use (p = 0.003) were found with positive changes at 12 years, and psychiatric admissions P = 0.011 (12 years) and social work contacts (P = 0.043)(30 years) were also similarly reduced. Those with personality disorder at baseline had fewer positive changes (P = 0.018) than others at 12 years and fewer positive occupational changes at 30 years (P = 0.041). Service use was greatly reduced in those with positive events with 50–80% more time free of all psychotropic drug treatment (P < 0.001). Instrumental positive change had greater effects than imposed changes.

Conclusions

Positive environmental change has a favourable impact on clinical outcome in common mental disorders. Although studied naturalistically in this study the findings suggest that if harnessed as a therapeutic intervention, as in nidotherapy and social prescribing, it would yield therapeutic dividends.
The full-stage creep model based on fractional differentiation and Perzyna overstress function for deeply buried soft rock
Authors: Yang Liu , Zhou Hui , Liu Rongfei , Yang Fanjie , Zhang Chuanqing , Liu Wenbo 
Published: March 2023

Abstract
Aiming at the problem that the traditional rock creep constitutive model cannot accurately describe the full-stage creep characteristics of rock, this paper proposes the FBNVP model that can describe the creep characteristics of deeply buried soft rocks in full-stage. Based on fractional differential theory, this model improves the viscosity element and can accurately describe the nonlinear growth process in the stable creep stage. The nonlinear viscoplastic element is constructed based on fractional exponential equation, which can accurately describe the accelerated growth process of creep stage III. The model accurately expresses the three-dimensional constitutive equation under viscoplastic conditions based on the Perzyna overstress function. The indoor uniaxial and triaxial creep test results of chlorite schist in Jinping II hydropower station verify the correctness of the one-dimensional and three-dimensional analytical solutions of the FBNVP model. The results show that compared with the traditional creep model the FBNVP model can accurately describe the creep characteristics of deeply buried soft rock in the full-stage. The model has the characteristics of accurate description, few parameters, clear physical significance and wide application range. It can provide reliable theoretical support for creep analysis of deeply buried soft rock.
Gap-filling properties of adhesives used for cross-laminated timber
Authors: Miyazaki Junko , Miyamoto Kohta , Tomura Shinichiro , Ohashi Yoshinori , Matsumoto Kazushige , Furuta Naoyuki , Takanashi Ryuya 
Published: March 2023

Abstract
Cross-laminated timber (CLT) laminates layers of laminae side by side, with the fiber direction of each layer orthogonal to each other. Therefore, any error in the thickness of the laminae may cause gaps in the glue lines, leading to adhesion failure. In this study, a three-layer CLT with a thin lamina inserted in the inner layer was manufactured, and the gap-filling performance of adhesives and the allowable error for lamina thickness were investigated. The outer layer of CLT was arranged with 30.0 mm-thick laminae, and the inner layer alternated between 30.0 mm-thick lamina and thin laminae (29.9, 29.7, and 29.5 mm). One-component polyurethane adhesives (PUR), emulsion polymer-isocyanate (EPI) adhesives, and phenol-resorcinol-formaldehyde resin (PRF) were used. The glue line thickened when the lamina thinned down in PUR and EPI. By contrast, the glue line thickness at the lamina thickness of 29.5 mm in PRF was almost the same as the glue line thickness without gaps. Delamination tests and block shear test showed that the PUR had a low delamination even at 29.5 mm thickness and a high wood failure rate (WF, > 95%), indicating good adhesion. For EPI, the lamina thicknesses of 29.7 and 29.5 mm showed an increase in delamination and a decrease in WF. For the PRF, an increase in delamination and a decrease in WF were observed at a lamina thickness of 29.5 mm. These results indicated that good adhesive properties can be obtained with a lamina thickness error of 0.1 mm for EPI and 0.3 mm for PRF.
Generalized Momentum implied by GUP with a Nonrelativistic Harmonic Oscillator
Authors: Khorram-Hosseini Seyed Amin , Zarrinkamar Saber , Panahi Hossein 
Published: March 2023

Abstract
We consider the Schrödinger equation with a generalized form of uncertainty principle and solve the problem up to a third-order correction to the arising equation. The particle in box and harmonic oscillator cases are considered in this formulation and various thermodynamic properties are reported including entropy, internal energy, chemical potential, specific heat, etc. Various consequences of the GUP are commented.
Establishment and validation of prognostic model of lung adenocarcinoma based on apoptosis-related genes
Authors: Zhang Wei , Zhu Wentao , Xu Suwei , Liu Yu 
Published: March 2023

Abstract
Objective: Apoptosis is an autonomous cell death process controlled by genes that can keep the internal environment of cells relatively stable. Lately, many studies have shown that apoptosis plays an important role in the construction of tumor microenvironment, mainly through the release of a series of regulatory factors to control cell growth. Therefore, it is very valuable to find and explore the possible role of apoptosis in the pathogenesis of lung cancer and its impact on the prognosis of patients.
Materials and Methods: We selected 10 apoptosis-related genes and used different statistical methods to construct a model to predict the survival and prognosis of patients with lung adenocarcinoma. Univariate and multivariate Cox analysis were used to evaluate the predictive power and value of prognostic models, as well as receiver operating characteristic (ROC) curve analysis.
Results: We defined two subgroups (cluster1 and cluster2). Compared with cluster1, cluster2 was named "apoptosis inhibition subgroup". The survival prognosis of cluster1 was significantly better than that of cluster2, and the infiltration of immune cells in cluster2 suggested that its immune system was inhibited. Then, we established a new prognostic model of apoptosis-related genes to identify high-risk patients with lung adenocarcinoma. Two types of Cox proportional hazards analysis and ROC curve showed that our model can be used as a new independent factor for the prognosis of lung adenocarcinoma patients, and had strong predictive ability.
Conclusion: Apoptosis is involved in the formation and development of lung adenocarcinoma and plays an important role. Our survival model can better predict the survival and prognosis of lung adenocarcinoma, and our study may be helpful for further research on new therapeutic targets and precise individualized treatment in the future.
A novel method for experiments in a one-atmosphere box furnace
Authors: Linzerová Dominika , Špillar Václav , Fabbrizio Alessandro 
Published: March 2023

Abstract
We present a conceptually simple method to perform high-temperature experiments in a one-atmosphere box furnace that has a negligible cost of materials. The experimental setup consists of two commercially available materials and can be customized to sample or furnace size with few limitations. Furthermore, the design allows easy extraction of samples in one piece, making them eligible for textural analysis.
The setup comprises a graphite capsule and a fireclay shell, the latter of which acts as a heat-resistant protective shield. Containers must be individually hand-crafted, but each can hold multiple samples. The setup can be reliably used in temperature conditions below the heat tolerance limit of the commercial fireclay, commonly ~1400 °C. Moreover, the graphite capsule buffers the oxygen fugacity to strongly reducing conditions during the experiment. The main advantage of our method lies in the utilization of easily accessible and low-cost materials that provides a widely applicable experimental setup easily used at larger scales. The method was developed during an experimental study of magmatic crystal-liquid suspensions and was reliable for experiments lasting for up to 36 h.
Promising Repurposed Antiviral Molecules to Combat SARS-CoV-2:
A Review
Authors: Ratan Yashumati , Rajput Aishwarya , Jain Vivek , Mishra Dinesh Kumar , Gautam Rupesh Kumar , Pareek Ashutosh 
Published: March 2023

Abstract:
COVID-19, an extremely transmissible and pathogenic viral disease, triggered a global
pandemic that claimed lives worldwide. To date, there is no clear and fully effective treatment for
COVID-19 disease. Nevertheless, the urgency to discover treatments that can turn the tide has led
to the development of a variety of preclinical drugs that are potential candidates for probative results.
Although most of these supplementary drugs are constantly being tested in clinical trials
against COVID-19, recognized organizations have aimed to outline the prospects in which their
use could be considered. A narrative assessment of current articles on COVID-19 disease and its
therapeutic regulation was performed. This review outlines the use of various potential treatments
against SARS-CoV-2, categorized as fusion inhibitors, protease inhibitors, and RNA-dependent
RNA polymerase inhibitors, which include antiviral drugs such as Umifenovir, Baricitinib, Camostatmesylate,
Nafamostatmesylate, Kaletra, Paxlovide, Darunavir, Atazanavir, Remdesivir, Molnupiravir,
Favipiravir, and Ribavirin. To understand the virology of SARS-CoV-2, potential therapeutic
approaches for the treatment of COVID-19 disease, synthetic methods of potent drug candidates,
and their mechanisms of action have been addressed in this review. It intends to help
readers approach the accessible statistics on the helpful treatment strategies for COVID-19 disease
and to serve as a valuable resource for future research in this area.
Molecular Targeting and Novel Therapeutic Approaches against
Fungal Infections
Authors: Kumar Abhishek , Bansal Priya , Katiyar Deepti , Prakash Surya , Raghavendra Rao Nidagurthi Guggilla 
Published: March 2023

Background:
Fungal infections have become a worldwide problem due to
their involvement in numerous diseases. The risk factors for fungal infections are multiple
surgeries, transplant therapies, frequent administration of antibiotics, cancer
treatments, and prosthetic devices. The problem of resistance in fungi against drug
therapies is widespread, becoming a severe health-related problem.

Objective:
The study's objective was to identify molecular targets that may open new
paths for fungal treatment.

Methods:
Several research and review articles were studied to gather information
regarding the novel mechanism of antifungal drugs. However, identifying novel targets
is challenging due to the similarities between host and fungal cells. Although, the
plasma membrane and cell wall of fungus offer various drug targets that may target to
fight against microbial infections. Unfortunately, biofilm formation and over-expression
of protein are a few mechanisms through which fungi develop resistance.

Results:
Despite these problems, several approaches have been working to prevent
and treat fungal infections. Modifying the chemical structure of antifungal drugs may
also improve their activity and pharmacokinetics. In this review article, we have discussed
the molecular targets and novel techniques to be used for the development of
antifungal drugs. In addition, different strategies to overcome resistance in fungi have
also been described.

Conclusion:
This article may be helpful for the researchers working on the discovery
and development of new antifungal works for resistance to fungal diseases.
Can the New BA.2.75 Sub-variant Lead To One More COVID-19 Wave?
Authors: Ray Suman Kumar , Mukherjee Sukhes 
Published: March 2023

:
The highly transmissible variation of COVID-19 has a new sub-variant known as a variant
BA.2.75, which was initially discovered in India and is now found in at least 10 more countries. The
World Health Organization (WHO) officials said that the new variant is actively being monitored. It
has yet to be determined if the new variation is more clinically severe than its predecessors. It is known
that the Omicron strain sub-variants are responsible for this rise in the worldwide COVID tally. It is
too early to know if this sub-variant exhibits additional immune evasion characteristics, or is more
clinically severe.

:
The extremely contagious BA.2.75 sub-variant of Omicron has been documented in India, but there is
no evidence yet that it has increased disease severity or dissemination. Many of the BA.2 lineage's sublineages
form a unique collection of mutations as it evolves. A related branch of the BA.2 lineage is
B.2.75. The size of genomic sequencing must be increased and maintained for the early detection of
the variant strains of SARS-CoV-2. BA.2.75 is the second generation of BA.2 variations and has a
high transmissibility level.