bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of the Atherogenic Index of Plasma and High-Sensitivity C-Reactive Protein with Incident Stroke Among Individuals Without Diabetes: A National Cohort Study
Authors: Yao Xiaotong , Liang Liting , Yang Manting , Liang Zhuoji , Piao Ying , chen Jia , Liang Yanling , Fang Xiaobo 
Published: January 2025

Abstract

Background
Both the atherogenic index of plasma (AIP), a surrogate marker of insulin resistance, and high-sensitivity C-reactive protein (hsCRP) are predictors of stroke risk and clinical outcomes. However, most existing evidence is derived from studies involving diabetic patients, which may lead to the overestimation of the impact of the AIP and hsCRP on stroke due to the confounding effects of diabetes. This study aimed to assess the combined and interactive effects of the AIP and hsCRP on stroke events in individuals without diabetes.
Methods
A total of 8,909 participants from the China Health and Retirement Longitudinal Study (CHARLS) 2011 who were free of stroke and diabetes at baseline were included. The AIP was calculated as lg[total cholesterol (mmol/L)/high-density lipoprotein cholesterol (mmol/L)]. A subset of 5,954 participants was studied to investigate the relationship between cumulative AIP (CumAIP) and hsCRP (CumAIP) exposure and stroke incidence.The CumAIP and CumCRP were also calculated using the same algorithm.The primary outcome was physician-diagnosed stroke occurring before 2020. We employed adjusted Cox proportional hazards regression and mediation analysis to investigate the associations between the AIP, hsCRP, and stroke events.
Results
Over nine years of follow-up, 696 new stroke cases were recorded.Compared with individuals with low AIP (<0.302 [median level]) and hsCRP <1 mg/L, those with elevated levels of both the AIP and hsCRP had the highest overall risk of stroke (adjusted HR [aHR]: 1.69; 95% CI: 1.36–2.10). In a 5-year subset analysis, 497 participants suffered a stroke. Compared with individuals with low risk (CumAIP<1.29 [median level] and CumhsCRP < 4.02 mg/L [median level]), those with high risk had the highest overall risk of stroke (adjusted HR [aHR]: 1.41; 95% CI: 1.10-1.82). Moreover, hsCRP significantly mediated 5.61% of the association between the AIP and stroke, whereas the AIP mediated 1.86% of the association between hsCRP and stroke.
Conclusions
The AIP and hsCRP exhibit coexposure effects and mutual mediation in with regard to the risk of stroke. The combined assessment of the AIP and hsCRP should be promoted for residual risk stratification and primary prevention of stroke in individuals without diabetes, particularly among middle-aged populations.
Identification of Novel COL4A5 Variants and Prenatal Diagnosis in Three Large Families
Authors: Zeng Baitao , Yu Yao , Liu Cong , Li Xinyu , Lu Qing , Chen Zhongfa , Chen Jia , Zou Jun , Yang Bicheng , Liu Yanqiu , Zou Yongyi 
Published: January 2025

Abstract

Alport syndrome (AS) is the second-most frequent monogenic kidney disease and 85% of cases are caused by mutations in the genes of the α5 chains of collagen type IV (COL4A5). The early diagnosis and treatment are essential for the prognosis of AS. The clinical phenotypes of AS are very variable, which is challenging to diagnose. Genetic diagnosis is sensitive and accurate, which can recognize the affected individuals with mild phenotype for early diagnosis and predict the age at renal failure for early treatment. In addition, genetic testing will offer the available reproductive options, including prenatal diagnosis and preimplantation genetic testing (PGT). In this study, three novel COL4A5 variants (c.1834G > T, c.865G > A and c.1032 + 5G > A) were found. These variants co-segregated with the disease in multiple affected family members. In vitro splicing assay indicated that the c.1032 + 5G > A variant resulted in aberrant splicing involving exon 18 skipping. The healthy babies without these novel COL4A5 variants were born by PGT or prenatal diagnosis, respectively. Three novel variants in COL4A5 gene can provide insights into further genetic counseling or genotype–phenotype correlations.
Higher Inhalation/Exhalation Ratio during Spontaneous Breathing Associates to Poor Mental Health in University Students
Authors: Liang Wen-Ming , Jiang Kai , Hendrikson Adomas , Truskauskaitė Inga , Griškova-Bulanova Inga , Xiao Jing , Ren Fei-Fei , Du Yin-Ling , Rukšėnas Osvaldas 
Published: January 2025

Abstract

Background Breathing exercises, particularly those involving altered inhalation/exhalation duration ratios (I/E ratios) and increased abdominal movement, have demonstrated the potential for alleviating symptoms of mental health issues. However, it remains unclear which approach is more effective. This study aims to examine how resting respiratory patterns (e.g., I/E ratios and abdominal movement) relate to mental health, potentially guiding psychologists in recommending tailored breathing exercises.Methods A total of 240 university students (120 male and 120 female) were recruited by systematic sampling. The I/E ratio and the contribution of abdominal movement to the sum of abdominal and thoracic movements AM/(AM + TM) were recorded by respiration belts, while depression, anxiety, and stress levels were assessed with the DASS-21. Data were analyzed for each gender; each gender being categorized into either a low or high level symptom category.Results Women with high stress symptoms exhibited significantly lower I/E ratios (a lower I/E ratio indicates breathing with relatively shorter inhalation and longer exhalation) compared to those with lower stress symptoms (n = 117, F = 4.198, p = 0.043, ηp² = 0.035). A negative correlation was observed between I/E ratios and depression in women (n = 117, r = -0.211, p = 0.023). For students with high anxiety symptoms, I/E ratios were negatively correlated with anxiety scores in both men (n = 61, r = -0.292, p = 0.022) and women (n = 70, r = -0.392, p < 0.001). There were no substantial correlations between abdominal movement and mental health.Conclusions In general, university students who exhibit relatively shorter inhalations and longer exhalations tend to have poorer mental health, especially among women; This respiratory pattern may represent an autonomic compensatory strategy for coping with psychological distress. More attention could be devoted to breathing exercises involving altered I/E ratios as part of mental health management programs.
Assessing Market Food Diversity of three Food Environments of Nairobi, Kenya using Spatial and Descriptive Analyses
Authors: Adundo Lucy Apiyo , Annys Sofie 
Published: January 2025

Abstract

The food environment (FE) is the interface where consumers interact to acquire and consume their food. Over the last two decades, the FE has changed due to lifestyle changes, globalisation, economic disparities and supermarketization. In addition, research on the food environment has focused mostly on high-income countries. Our study shows the novelty of assessing the food environment using the Market Food Diversity (MFD) in Nairobi, a rapidly urbanising city. We assessed the food environment of three income regions of Nairobi – using Market Food Diversity derived from the Minimum Dietary Diversity of Women (MDD-W) tool. In August – December 2023, we used the Global Positioning System (GPS) and a list-based questionnaire to map 3548 food vendors. Descriptive statistics show that informal vendors (86%) dominated across the three income regions compared to formal vendors (14%). The high-income region was characterised by the presence of more formal vendors (24.2%) compared to the other income regions. There were statistically significant differences in food group variations among vendors. Market Food diversity was highest in the high-income (3.11) region compared to the low- (2.71) and middle-income (2.35) regions. Our results underscore the need for policy implementation that supports local food environments that promote access to healthier and more nutritious diets, particularly in rapidly urbanizing cities of low- and middle-income countries (LMICs) such as Nairobi. Distinguishing income regions highlights the need for local policy officials to intervene to promote access to much healthier foods across the settlements.
Starptautiskā konference „Aktuāli baltu valodu pētniecības jautājumi“, veltīta Latvijas Universitātes profesores Martas Rudzītes (1924–1996) 100 gadu atcerei
Authors: Vanags Pēteris 
Published: January 2025

2024. gada 4. novembrī tika atzīmēta latviešu valodnieces Martas Rudzītes (1924–1996) simtgade. Viņas mantojums latviešu valodas zinātnē ir ievērojams, īpaši dialektoloģijā un valodas vēstures izpētē. Lai godinātu viņas ieguldījumu, Latvijas Universitātē tika organizēta virkne pasākumu, kuru laikā notika piemiņas pasākumi, zinātniskas konferences un diskusijas.
Simtgades atcerē tika rīkota starptautiska zinātniskā konference, kurā piedalījās zinātnieki no Latvijas, Lietuvas, Polijas, Vācijas un Zviedrijas. Konferences tēmas bija saistītas ar baltu valodu pētniecības jautājumiem.
Sarīkojumi, pieminot profesores Martas Rudzītes simtgadi, visa novembra garumā apliecināja cieņu daudzu latviešu valodnieku skolotājai un viņas devumam latviešu valodas izpētē.
Ergonomic Analysis of Working Positions in Petis Processing with the RULA Method at UD Murni Sidoarjo
Authors: Immannulloh Dimas , Tranggono Tranggono 
Published: January 2025

UD Murni Sidoarjo is a company that focus on making petis as traditional food of Sidoarjo. But, often they experience ergonomic problems which results in Work Related Musculoskeletal Disorders (WRMSDs) for their workers. The method that used in this study, namely Rapid Upper Limb Assesment (RULA) which is a method for assessing posture, style, and movement of an activity related to upper limb users. The main objective in this study is to analyze the working postures of filters sector from petis processing industry by using Rapid Upper Limb Assesment (RULA) in CATIA V5R21 software. 5 out of 5 workers postures from filters sector indicated a high risk score of 6, indicating changes in the posture is needed to be done. Tool design with ergonomic interventions are suggested and the improved posture was evaluated using Conventional RULA Asessment and CATIA V5R21 software. From 2 asessment, the posture indicated a score of 3, indicating low risk. The results from this study indicate that awkward working posture risks can be minimized effectively using ergonomic interventions with design of working tools in solidworks software that being analyzed with CATIA V5R21 software. The limitation of this study is the tool that had been design is not used by real workers, the design of the tool is only emplimented into CATIA V5R21 software which is used for RULA asessment, the design can be realized by any future researcher for another impact not just posture but also production, performance, and the others.
Mortality and reoperations following treatment of acetabular fractures in patients ≥ 70 years: a retrospective cohort study of 247 patients
Authors: Ljungdahl Johan , Hernefalk Björn , Pallin Anna , Brüggemann Anders , Hailer Nils P , Wolf Olof 
Published: January 2025

Background and purpose: Evidence for long-term outcomes following acetabular fractures in older adults is limited. We aimed to evaluate mortality, complications, and need for subsequent surgical procedures in operatively and nonoperatively treated older patients with acetabular fractures.Methods: Patients aged ≥ 70 years with acetabular fractures treated at Uppsala University Hospital between 2010 and 2020 were included. Fractures were classified according to Letournel. Local medical records were analyzed and cross-referenced with the Swedish Arthroplasty Register to identify reoperations and delayed arthroplasty procedures. Follow-up time ranged from 2–12 years. Primary outcome was mortality 1 year after injury. Descriptive statistics, survival analysis using the Kaplan–Meier method, and logistic regression models were used.Results: 247 patients (67% men) with a median age of 80 years (range 70–102) were included. Most patients were ASA class 3 (67%). 148 (60%) patients were treated operatively. The 1-year mortality was 15% (95% confidence interval [CI] 9–21) in the operatively and 29% (CI 19–37) in the nonoperatively treated group. Difference in adjusted mortality rates between treatments did not reach statistical significance. 20% of patients treated with open reduction internal fixation (ORIF) underwent some form of reoperation. In the nonoperatively treated group, 1% had a delayed THA.Conclusion: The 1-year mortality following acetabular fractures in older people was 21% (CI 15–26), underscoring the frailty of this patient group. ORIF alone was associated with a 20% reoperation rate while the rate of delayed surgical treatment in patients selected for nonoperative treatment was 1%.
PENGEMBANGAN APLIKASI MOBILE LEARNING FISIKA SEBAGAI MEDIA PEMBELAJARAN PENDUKUNG
Authors: Gunawan Indra 
Published: January 2025

Abstract: The objective of this research is to create a supporting instructional media in the form of mobile learning of main material for Senior Secondary School students. The created mobile learning was played on mobile phone that supports flash player, mainly Symbian S60 3rd based mobile phone. The method applied in this research was research and development. The first step was limited to the material of heat transfer. The trial of an application was conducted to 2 specialized lecturers, 2 media experts, 2 Physics teachers of Senior Secondary School, and 44 students of Al- Azhar Senior Secondary School, Bandar Lampung. Indicators used to assess the created instructional media were the appropriateness of the content to the purpose, appropriateness of instruction to the technical quality. Marks of the three indicators were above 80% so that the created mobile learning was categorized as very good. Based on the findings, it may be concludedthat the instructional media in the form of mobile learning can be used as a supporting instructional media for Senior Secondary School students to learn Physics subject. Keywords: instructional media, mobile learning, heat transfer, physic subject, and Senior Secondary School.
Implementasi Pembelajaran Bervisi SETS di Sekolah
Authors: Latifah Sri 
Published: January 2025

Pembelajaran tentang alam harus dapat disajikan sebagai suatu proses penemuan dan terkait dengan pengalaman peserta didik, sehingga pengetahuan yang diperoleh bersifat lama, dapat diingat, dan mampu meningkatkan penalaran siswa dan kemampuan untuk berfikir bebas. Peran pendidik sebagai narasumber yang bijak dan berpengetahuan serta berfungsi sebagai sutradara yang mengendalikan proses pembelajaran dan siap membantu siswa apabila ada kemacetan proses pembelajaran atau melantur tanpa arah. Wawasan SETS (Science, Environment, Technology, Society) yang diaplikasikan ke dalam proses pembelajaran Fisika diharapkan dapat membawa sistem pembelajaran untuk menghasilkan lulusan yang dapat menerapkan pengetahuan yang diperolehnya guna meningkatkan kualitas hidup manusia tanpa harus membahayakan lingkungannya.
Perhitungan Kecepatan Perambatan Gelombang Daerah Bantul dengan Menggunakan Metode ABC Seismik Refraksi
Authors: Sari Dian Novita 
Published: January 2025

Telah dilakukan penelitian di daerah Bantul dan sekitarnya dengan menggunakan metode Seismik Refraksi. Tujuan dari penelitian seismik refraksi ini yaitu untuk mengetahui besarnya kecepatan perambatan gelombang lapisan batuan di bawah permukaan pada daerah penelitian. Metode refraksi pada dasarnya memanfaatkan fenomena atau gejala penjalaran gelombang yang terbiaskan pada bidang batas.Kecepatan gelombang seismik pada lapisan pertama dari hasil pengolahan metode ABC dengan range 399 m/s – 1200 m/s yang di indikasikan sebagai lapisan aluvial (soil). Pada lapisan kedua, di peroleh kecepatan gelombang refraksi pada bidang refraktor dengan renge 547 m/s – 2881 m/s yang diindikasikan sebagai batu pasir tuffan.
Tinjauan Struktur Penelitian, Penulisan Ilmiah dan Teknik Penulisan Ilmiah
Authors: Wati Widya 
Published: January 2025

Banyak bentuk dan cara penulisan yang dapat ditemukan dalam berbagaipedoman penulisan. Bentuk luarnya bisa berbeda namun jiwa dan enalarannya sama. Dengan demikian yang paling penting bukan saja mengetahui teknik-teknik pelaksanaannya melainkan memahami dasar pikiran yang melandasinya. Pemilihan bentuk dan cara penulisan dari khasanah yang tersedia merupakan masalah selera dan preferensi perorangan dengan memperhatikan berbagai factor lainnya seperti masalah apa yang sedang dikaji, siapa pembaca tulisan ini dan dalam rangka kegiatan keilmuan apa karya ilmiah ini disampaikan.Berdasarkn pemikiran tersebut maka akan coba dibahas alur-alur jalanpikiran yang terdapat dalam penelitian ilmiah yang dikaitkan dengan penulisan ilmiah. Dalam makalah ini juga akan coba dibahas mengenai tema pokok sebuah proses penelitian. Tema pokok ini akan dijabarkan secara logis dan kronologis dari metode keilmuan.
Pemanfaatan Teknologi Informasi dan Komunikasi (TIK) dalam Pembelajaran
Authors: Gunawan Zeni 
Published: January 2025

Teknologi informasi dan komunikasi (TIK) adalah sesuatu teknologi baik perangkat keras (hardware) maupun perangkat lunak (software) yang digunakan untuk mengelola data/informasi dan komunikasi. Dalam prakteknya teknologi diwakili oleh komputer (perangkat keras) dan program-program aplikasi (perangkat lunak). Data/informasi yang dikelola dan dihasilkan dalam bentuk berbagai media, seperti teks, grafik, gambar diam, foto, film, animasi, dan simulasi. Cara-cara berkomunikasinya memungkinkan untuk dilakukan secara maya.
Brain Based Teaching Pada Mata Pelajaran IPA
Authors: Sesmiarni Zulfani 
Published: January 2025

Proses pembelajaran melibatkan dan mengarahkan aktivitas peserta didik untuk mencapai berbagai tujuan yang telah direncanakan secara sistematik. Selain itu pembelajaran juga merupakan usaha untuk mengelola lingkungan dengan sengaja agar seseorang membentuk diri secara positif dalam kondisi tertentu. Pembelajaran tidak terlepas dari usaha pendidik untuk memfasilitasi peserta didik mencapai tujuan pembelajaran yang telah ditetapkan. Dalam proses pembelajaran, unsur yang perlu diperhatikan terutama pada aspek perbedaan karakteristik individu. Salah satu paradigma pembelajaran yang memfasilitasi keberagaman kemampuan siswa adalah dengan brain based teaching. Pembelajaran ini melibatkan seluruh aspek pembelajaran, yang dimulai dengan pembelajaran emosional, kognitif, fisik, social dan refleksi. Diharapkan dengan melibatkan semua potensi yang ada dalam otak siswa, maka pembelajaran akan dapat menjadi bermakna.
MODEL PEMBELAJARAN JUST IN TIME TEACHING (JITT) BERBANTUAN WEBSITE PADA TOPIK LISTRIK ARUS BOLAK-BALIK UNTUK MENINGKATKAN KETERAMPILAN BERPIKIR KREATIF SISWA SMA
Authors: Irwandani Irwandani 
Published: January 2025

Telah dilakukan penelitian dengan metode quasy experiment tentang penerapan pembelajaran JiTT berbantuan website untuk mengetahui peningkatan keterampilan berpikir kreatif siswa pada materi listrik arus bolak-balik. Sampel penelitian adalah siswa kelas X SMA tahun pelajaran 2012/2013. Sampel penelitian terbagi dalam dua kelas, yaitu kelas eksperimen dan kelas kontrol. Kelas eksperimen mendapatkan model pembelajaran JiTT berbantuan websitesedangkan kelas kontrol mendapat model pembelajaran JiTT tanpa bantuan website.Hasil uji statistik menunjukkan bahwakelas eksperimen secara signifikan lebih dapat meningkatkan keterampilan berpikir kreatif siswanyadibandingkan kelas kontrol. Dapat disimpulkan bahwa pembelajaran JiTT berbantuan website dapat lebih meningkatkan keterampilan berpikir kreatif siswa.
Pemodelan Gravity Kecamatan Dlingo Kabupaten Bantul Provinsi D.I. Yogyakarta
Authors: Sari Dian Novita 
Published: January 2025

Telah dilakukan penelitian dengan menggunakan metode gravity di daerah Dlingo, Kabupaten Bantul, Provinsi D.I. Yogyakarta. Penelitian ini bertujuan untuk membuat model struktur bawah permukaan tanah daerah Dlingo Kabupaten Bantul dengan menggunakan metode gravity. Metode gravity adalah metoda penyelidikan geofisika yang didasarkan pada variasi percepatan gravitasi di permukaan bumi. Pengukuran gravitasi ini disebabkan oleh adanya perbedaan dari medan gravitasi yang diakibatkan variasi massa di kerak bumi. Hasil yang didapat antara lain Sekitar 75% daerah penelitian didominasi oleh daerah dengan variasi percepatan gravitasi tinggi dan selebihnya merupakan daerah dengan variasi percepatan gravitasi rendah, Pemodelan downward memperlihatkan bahwa dibawah permukaan tanah terdapat dua tubuh batuan yaitu batupasir dan batugamping dengan densitas 1,9g/cm3 dan 2,385 g/cm3. Di daerah tersebut terdapat patahan berupa sesar pada koordinat disekitar X= 530800 dan Y= 9104200.
Online Group Discussion pada Mata Kuliah Teknologi Pembelajaran Fisika
Authors: Yuberti Yuberti 
Published: January 2025

Nowadays, gadged just like handphone and notebook more reachable so the quantities of the users are increase in Indonesia. It is common for us to see the students, employees, enterpreneurs until housewives using gadged anywhere and anytime. This phenomenon is spread widely along with the internet wifi and hotspot in many places start from official educational institute, government, and office centre, to the tourism object and shopping center. Also with internet café (Warnet) compete tightly with offering various facilities, and services with compete price. All cellphone service is also giving internet access in order to attract users. Some phenomena show more and more people who use the Internet and make it as a lifestyle for berintaksi, socialize, learn and get information. Widespread use of the Internet can be a great potential in the development of online learning system allows learners to access the information flexibly without limitation of time and place. Discussion no longer occur face to face, but can continue even in the virtual environment. As the implementation of other virtual learning methods. Implementation of online discussion itself is basically adopting the method of learning face to face discussionHarga gadged seperti handphone dan dan notebook kian hari kian terjangkau sehingga jumlah penggunanya di indonesia terus meningkat. Bukan lah suatu yang asing jika kita menjumpai para siswa, mahasiswa, karyawan, pengusaha hingga ibu rumah tangga menggunakan gadged di mana saja dan kapan saja. Fenomena ini diiringi dengan meluasnya jaringan internet nirkabel seperti hotspot dan wifi di berbagai tempat mulai dari institusi resmi pendidikan, pemerintahan, dan perkantoran, hingga tempat wisata,dan pusat perbelanjaan. Tidak mau ketinggalan warnet (warung internet) ikut bersaing ketat dengan menawarkan berbagai macam fasilitas, dan layanan dengan harga bersaing. Seluruh layanan seluler ponsel juga terus memberikan penawaran akses internet yang menggiurkan demi menarik minat penggunanya. Beberapa fenomena tersebut menunjukkan semakin banyak kalangan yang memanfaatkan internet dan menjadikanya sebagai gaya hidup untuk berintaksi, bersosialisasi, belajar dan mendapatkan informasi. Meluasnya pemanfaatan internet bisa menjadi potensi besar dalam pengembangan pembelajaran dengan sistem online memungkinkan pebelajar untuk mengakses infromasi secara fleksibel tanpa terbatas waktu dan tempat. Diskusi tidak lagi terjadi secara tatap muka, namun dapat terus berlangsung meskipun dalam lingkungan maya. Sebagaimana pelaksanaan metode pembelajaran maya lainnya. Pelaksanaannya diskusi online itu sendiri pada dasarnya mengadopsi dari metode pembelajaran diskusi tatap muka.