bluuebunny/crossref_metadata_2025_split huggingface dataset:
An interferometric SETI observation of Kepler-111 b
Authors: Wandia Kelvin , Garrett Michael A , Radcliffe Jack F , Garrington Simon T , Fawcett James , Gajjar Vishal , MacMahon David H E , Varenius Eskil , Campbell Robert M , Paragi Zsolt , Siemion Andrew P V 
Published: April 2023

ABSTRACT
The application of very long baseline interferometry (VLBI) to the search for extraterrestrial intelligence (SETI) has been limited to date, despite the technique offering many advantages over traditional single-dish SETI observations. In order to further develop interferometry for SETI, we used the European VLBI network (EVN) at 21 cm to observe potential secondary phase calibrators in the Kepler field. Unfortunately, no secondary calibrators were detected. However, a VLBA primary calibrator in the field, J1926+4441, offset only ∼1.88 arcmin from a nearby exoplanet Kepler-111 b, was correlated with high temporal $\left(0.25 \, \rm {s}\right)$ and spectral $\left(16384 \times 488\, \rm {Hz \ channels}\right)$ resolution. During the analysis of the high-resolution data, we identified a spectral feature that was present in both the auto and cross-correlation data with a central frequency of 1420.424 ± 0.0002 MHz and a width of 0.25 MHz. We demonstrate that the feature in the cross-correlations is an artefact in the data, associated with a significant increase in each telescope’s noise figure due to the presence of H i in the beam. This would typically go unnoticed in data correlated with standard spectral resolution. We flag (excluded from the subsequent analysis) these channels and phase rotate the data to the location of Kepler-111 b aided by the Gaia catalogue and search for signals with $\rm {SNR}\gt 7$ . At the time of our observations, we detect no transmitters with an equivalent isotropically radiated power ≳4 × 1015 W.
Left–right asymmetry of the visual system in the scallop Nodipecten nodosus (Bivalvia: Pectinidae)
Authors: Audino Jorge A , Serb Jeanne M , Marian José E A R 
Published: April 2023

ABSTRACT
Left–right asymmetries are consistent differences between the left and right sides and represent an intriguing feature of molluscan morphology. Interestingly, external asymmetries, such as inequivalve shells, are often coupled with lateralization in the nervous system, which often includes functional and structural specializations of the left or right sides. In the case of visual asymmetries, lateralized phenotypes frequently include left–right differences in eye position, structure and use. To investigate lateralization and visual asymmetries among bivalves, we examined the visual and nervous systems of the scallop Nodipecten nodosus. We characterized different eye morphologies in the species and determined eye-side frequencies. We also studied the anatomy of the nervous system, focusing on the parietovisceral ganglion (PVG). Our results reveal that the visual and nervous systems of the scallop N. nodosus comprise consistent left–right asymmetries: (1) a greater number of eyes on the left side, (2) increased size of the left PVG lateral lobe, (3) larger glomeruli in the left PVG lateral lobe and (4) radial pallial nerves associated with the left lateral lobe spaced more widely than the more compactly arranged pallial nerves associated with the right lateral lobe. In addition, eyes with a distinctive morphology, where the optic vesicle is rotated, are more frequent on the left side. Considering the habit of this species to rest on the right valve, we hypothesize that curved eyes might contribute to expanding the overall visual field. Even though bivalves are not typically considered in the literature on lateralization, accumulating evidence for scallops, as suggested by our results, indicates their potential to reveal novel patterns of visual asymmetry in benthic invertebrates.
How does low-skilled immigration affect native wages? Evidence from Employment Permit System in Korea
Authors: Dong Michell , Lee Jongkwan , Yang Hee-Seung 
Published: April 2023

Abstract
This study examines the effects of low-skilled immigration on the wages of native workers by analysing Korea’s temporary immigrant worker programme. Using firm-level survey data, we exploit exogenous variations in the number of foreign workers firms can hire to estimate the wage effects of immigration. We find that an increase in immigrant workers in a firm does not affect the firm-specific native wages, even though both native and immigrant workers mainly work in production jobs. Our results indicate that native and immigrant workers could possibly be imperfect substitutes even within narrowly defined occupations in a firm.
Immunogenicity of High-Dose Egg-Based, Recombinant, and Cell Culture–Based Influenza Vaccines Compared With Standard-Dose Egg-Based Influenza Vaccine Among Health Care Personnel Aged 18–65 Years in 2019–2020
Authors: Naleway Allison L , Kim Sara S , Flannery Brendan , Levine Min Z , Murthy Kempapura , Sambhara Suryaprakash , Gangappa Shivaprakash , Edwards Laura J , Ball Sarah , Grant Lauren , Zunie Tnelda , Cao Weiping , Gross F Liaini , Groom Holly , Fry Alicia M , Hunt Danielle , Jeddy Zuha , Mishina Margarita , Wesley Meredith G , Spencer Sarah , Thompson Mark G , Gaglani Manjusha , Dawood Fatimah S 
Published: April 2023

Abstract

Background
Emerging data suggest that second-generation influenza vaccines with higher hemagglutinin (HA) antigen content and/or different production methods may induce stronger antibody responses to HA than standard-dose egg-based influenza vaccines in adults. We compared antibody responses to high-dose egg-based inactivated (HD-IIV3), recombinant (RIV4), and cell culture–based (ccIIV4) vs standard-dose egg-based inactivated influenza vaccine (SD-IIV4) among health care personnel (HCP) aged 18–65 years in 2 influenza seasons (2018–2019, 2019–2020).

Methods
In the second trial season, newly and re-enrolled HCPs who received SD-IIV4 in season 1 were randomized to receive RIV4, ccIIV4, or SD-IIV4 or were enrolled in an off-label, nonrandomized arm to receive HD-IIV3. Prevaccination and 1-month-postvaccination sera were tested by hemagglutination inhibition (HI) assay against 4 cell culture propagated vaccine reference viruses. Primary outcomes, adjusted for study site and baseline HI titer, were seroconversion rate (SCR), geometric mean titers (GMTs), mean fold rise (MFR), and GMT ratios that compared vaccine groups to SD-IIV4.

Results
Among 390 HCP in the per-protocol population, 79 received HD-IIV3, 103 RIV4, 106 ccIIV4, and 102 SD-IIV4. HD-IIV3 recipients had similar postvaccination antibody titers compared with SD-IIV4 recipients, whereas RIV4 recipients had significantly higher 1-month-postvaccination antibody titers against vaccine reference viruses for all outcomes.

Conclusions
HD-IIV3 did not induce higher antibody responses than SD-IIV4, but, consistent with previous studies, RIV4 was associated with higher postvaccination antibody titers. These findings suggest that recombinant vaccines rather than vaccines with higher egg-based antigen doses may provide improved antibody responses in highly vaccinated populations.
Pyoperitoneum as a consequence of perinephric abscess spontaneous rupture. A case report
Authors: Alhalabi Marouf , Almokdad Rash , Alhalabi Mouhammad Zaher , Alhalbouni Mouhammad 
Published: April 2023

Abstract
Intra-abdominal infections are a common cause of severe sepsis and have a significantly high morbidity and mortality rate. Patients continue to present to hospitals with unacceptable delays in diagnosis or management, resulting in sepsis and organ failure, which lower their survival chances. We reported a rare case of a 64-year-old Syrian woman with a spontaneous rupture of a perinephric abscess that resulted in intra-abdominal infection and ascites, which led to sepsis and multiple organ failure despite resuscitation and antibiotic treatment according to guidelines. Although the recommendations for patients with intra-abdominal infection and hemodynamic instability differ, there is an agreement that surgery should be considered early when other interventional approaches have failed. Rupture of the perinephric abscess rarely produces intra-abdominal infection and ascites; effective care requires early and appropriate infection source identification. To avoid delays, doctors need to use academic methods in developing diagnoses and management.
Visceral Metastasis Predicts Response to New Hormonal Agents in Metastatic Castration-Sensitive Prostate Cancer
Authors: Yekedüz Emre , McKay Rana R , Gillessen Silke , Choueiri Toni K , Ürün Yüksel 
Published: April 2023

Abstract
Visceral metastasis (VM) and a higher number of bone metastasis generally define high volume/risk in patients with metastatic castration-sensitive prostate cancer (mCSPC). Subgroup analysis of pivotal trials did not show a clear benefit of second-generation non-steroidal anti-androgens (NSAAs) in patients with VM. However, subgroup analysis of the trial assessing abiraterone acetate, a CYP 17 inhibitor, plus prednisone (AAP) showed an improved overall survival (OS) in patients with mCSPC with VM. We searched MEDLINE, Web of Science, and congress abstracts for the phase III randomized controlled trials of second-generation NSAAs and AAP in patients with mCSPC. In this pooled analysis, we included 6485 patients from the 6 phase III trials. The rate of patients with VM was 15.2%. Interestingly, in contrast to NSAAs, AAP seems to be effective in improving OS among patients with VM (hazard ratio, HR: 0.89, 95% CI, 0.72-1.11, P = .30 for second-generation NSAAs; HR: 0.58, 95% CI, 0.40-0.84, P = .004 for AAP). In contrast, both second-generation NSAAs (HR: 0.63, 95% CI, 0.57-0.70, P &lt; .001) and AAP (HR: 0.68, 95% CI, 0.57-0.81, P &lt; .001) improved OS in patients without VM. In this pooled analysis, we demonstrate that while AAP provided an OS improvement in patients with VM, second-generation NSAAs did not demonstrate a similar OS benefit in this population.
Investigating physical states of molecular gas in the overlapping region of interacting galaxies NGC 4567/4568 using ALMA
Authors: Kaneko Hiroyuki , Tokita Shoya , Kuno Nario 
Published: April 2023

Abstract
We present ALMA observations of a diffuse gas tracer, CO(J = 1–0), and a warmer and denser gas tracer, CO(J = 3–2), in the overlapping region of interacting galaxies NGC 4567/4568, which are in the early stage of interaction. To understand the impact of galaxy interactions on molecular gas properties, we focus on interacting galaxies during the early stage and study their molecular gas properties. We investigate the physical states of a filamentary molecular structure at the overlapping region, which was previously reported. Utilizing new higher-resolution CO(J = 1–0) data, we identify molecular clouds within overlapping and disk regions. Although the molecular clouds in the filament have a factor of two higher average virial parameter (0.56 ± 0.14) than that in the overlapping region (0.28 ± 0.12) and in the disk region (0.26 ± 0.16), all the identified molecular clouds are gravitationally bound. These clouds in the filament also have a larger velocity dispersion than that in the overlapping region, suggesting that molecular gas and/or atomic gas with different velocities collide there. We calculate the ratio of the integrated intensity of CO(J = 3–2) and CO(J = 1–0) (= R3−2/1−0) on the molecular cloud scale. The maximum R3−2/1−0 is 0.17 ± 0.04 for all identified clouds. R3−2/1−0 for the molecular clouds in the filament is lower than that of the surrounding area. This result contradicts the predictions of previous numerical simulations, which suggested that the molecular gas on the collision front of galaxies is compressed and becomes denser. Our results imply that NGC 4567/4568 is in a very early stage of interaction; otherwise, the molecular clouds in the filament would not yet fulfill the conditions necessary to trigger star formation.
Preliminary results from a randomized, controlled, cross-over trial of intrathecal oxytocin for neuropathic pain
Authors: Eisenach James C , Curry Regina S , Houle Timothy T 
Published: April 2023

Abstract

Objective
Compare intrathecal oxytocin, 100 µg to placebo on ongoing neuropathic pain and mechanical hyperalgesia and allodynia.

Study design
Randomized, controlled, double-blind cross-over

Setting
Clinical research unit

Subjects
Individuals aged 18 to 70 years with neuropathic pain for at least 6 months.

Methods
Individuals received intrathecal injections of oxytocin and saline, separated by at least 7 days, and ongoing pain in neuropathic area (VAS [visual analog scale]) and areas of hypersensitivity to von Frey filament and cotton wisp brushing were measured for 4 hours. Primary outcome was VAS pain in the first 4 hours after injection, analyzed by linear mixed effects model. Secondary outcomes were verbal pain intensity scores at daily intervals for 7 days and areas of hypersensitivity and elicited pain for 4 hours after injections.

Results
The study was stopped early after completion of 5 of 40 subjects planned due to slow recruitment and funding limitations. Pain intensity prior to injection was 4.75 ± 0.99 and modeled pain intensity decreased more after oxytocin than placebo to 1.61 ± 0.87 and 2.49 ± 0.87, respectively (P = .003). Daily pain scores were lower in the week following injection of oxytocin than saline (2.53 ± 0.89 vs 3.66 ± 0.89; P = .001). Allodynic area decreased by 11%, but hyperalgesic area increased by 18% after oxytocin compared to placebo. There were no study drug related adverse effects.

Conclusion
Although limited by the small number of subjects studied, oxytocin reduced pain more than placebo in all subjects. Further study of spinal oxytocin in this population is warranted.

Trial registration
This study was registered at ClinicalTrials.gov on 03/27/2014 (NCT02100956). The first subject was studied on 06/25/2014.
Abnormalities of Regional Brain Activity in Patients With Schizophrenia: A Longitudinal Resting-State fMRI Study
Authors: Li Xue , Liu Qing , Chen Zhaonian , Li Yalin , Yang Ying , Wang Xiujuan , Guo Xiaoge , Luo Binbin , Zhang Yan , Shi Han , Zhang Luwen , Su Xi , Shao Minglong , Song Meng , Guo Suqin , Fan Lingzhong , Yue Weihua , Li Wenqiang , Lv Luxian , Yang Yongfeng 
Published: April 2023

Abstract

Background
Evidence from functional and structural research suggests that abnormal brain activity plays an important role in the pathophysiology of schizophrenia (SZ). However, limited studies have focused on post-treatment changes, and current conclusions are inconsistent.

Study Design
We recruited 104 SZ patients to have resting-state functional magnetic resonance imaging scans at baseline and 8 weeks of treatment with second-generation antipsychotics, along with baseline scanning of 86 healthy controls (HCs) for comparison purposes. Individual regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and degree centrality values were calculated to evaluate the functional activity. The Positive and Negative Syndrome Scale (PANSS) and MATRICS Consensus Cognitive Battery were applied to measure psychiatric symptoms and cognitive impairment in SZ patients.

Results
Compared with HCs at baseline, SZ patients had higher ALFF and ReHo values in the bilateral inferior temporal gyrus, inferior frontal gyrus, and lower ALFF and ReHo values in fusiform gyrus and precuneus. Following 8 weeks of treatment, ReHo was increased in right medial region of the superior frontal gyrus (SFGmed) and decreased in the left middle occipital gyrus and the left postcentral gyrus. Meanwhile, ReHo of the right SFGmed was increased after treatment in the response group (the reduction rate of PANSS ≥50%). Enhanced ALFF in the dorsolateral of SFG correlated with improvement in depressive factor score.

Conclusions
These findings provide novel evidence for the abnormal functional activity hypothesis of SZ, suggesting that abnormality of right SFGmed can be used as a biomarker of treatment response in SZ.
Acute evening high-intensity interval training may attenuate the detrimental effects of sleep restriction on long-term declarative memory
Authors: Frimpong Emmanuel , Mograss Melodee , Zvionow Tehila , Paez Arsenio , Aubertin-Leheudre Mylene , Bherer Louis , Pepin Véronique , Robertson Edwin M , Dang-Vu Thien Thanh 
Published: April 2023

Abstract
Recent evidence shows that a nap and acute exercise synergistically enhanced memory. Additionally, human-based cross-sectional studies and animal experiments suggest that physical exercise may mitigate the cognitive impairments of poor sleep quality and sleep restriction, respectively. We evaluated whether acute exercise may offset sleep restriction’s impairment of long-term declarative memory compared to average sleep alone. A total of 92 (82% females) healthy young adults (24.6 ± 4.2 years) were randomly allocated to one of four evening groups: sleep restriction only (S5, 5–6 h/night), average sleep only (S8, 8–9 h/night), high-intensity interval training (HIIT) before restricted sleep (HIITS5), or HIIT before average sleep (HIITS8). Groups either followed a 15-min remote HIIT video or rest period in the evening (7:00 p.m.) prior to encoding 80 face-name pairs. Participants completed an immediate retrieval task in the evening. The next morning a delayed retrieval task was given after their subjectively documented sleep opportunities. Long-term declarative memory performance was assessed with the discriminability index (dʹ) during the recall tasks. While our results showed that the dʹ of S8 (0.58 ± 1.37) was not significantly different from those of HIITS5 (−0.03 ± 1.64, p = 0.176) and HIITS8 (−0.20 ± 1.28, p = 0.092), there was a difference in dʹ compared to S5 (−0.35 ± 1.64, p = 0.038) at the delayed retrieval. These results suggest that the acute evening HIIT partially reduced the detrimental effects of sleep restriction on long-term declarative memory.
Temporal associations between nightly sleep with daytime eating and activity levels in free-living young adults
Authors: Hoopes Elissa K , Brewer Benjamin , Robson Shannon M , Witman Melissa A , D’Agata Michele N , Malone Susan K , Edwards David G , Patterson Freda 
Published: April 2023

Abstract

Study Objectives
This study aimed to quantify the temporal associations between nightly sleep quantity and timing with daytime eating behavior and activity levels in free-living (i.e. non-experimental) settings.

Methods
Generally healthy young adults (N = 63; 28.9 ± 7.1 years) completed concurrent sleep (wrist actigraphy), eating (photo-assisted diet records), and activity (waist actigraphy) assessments over 14 days. Multilevel models quantified the associations between nightly sleep (total sleep time, timing of sleep and wake onset) with next-day eating behavior (diet quality, caloric intake, timing of eating onset/offset, eating window duration) and activity levels (total physical activity, sedentary time). Associations in the reverse direction (i.e. eating and activity predicting sleep) were explored. Models adjusted for demographic and behavioral confounders and accounted for multiple testing.

Results
At within- and between-subject levels, nights with greater-than-average total sleep time predicted a shorter eating window the next day (all p ≤ 0.002). Later-than-average sleep and wake timing predicted within- and between-subject delays in next-day eating onset and offset, and between-subject reductions in diet quality and caloric intake (all p ≤ 0.008). At within- and between-subject levels, total sleep time was bidirectionally, inversely associated with sedentary time (all p &lt; 0.001), while later-than-average sleep and wake timing predicted lower next-day physical activity (all p ≤ 0.008).

Conclusions
These data underscore the complex interrelatedness between sleep, eating behavior, and activity levels in free-living settings. Findings also suggest that sleep exerts a greater influence on next-day behavior, rather than vice versa. While testing in more diverse samples is needed, these data have potential to enhance health behavior interventions and maximize health outcomes.
Using the increasing vaccination model and the moderating roles of chronic medical conditions and education to understand COVID-19 vaccination uptake in Singapore
Authors: Chen Xingyu Ken , Ong Juanita , Neo Loo Seng , Tan Li Feng 
Published: April 2023

Abstract
COVID-19 vaccination programmes have helped reduce deaths and morbidity from the pandemic and allowed for the resumption of normal life. However, vaccine hesitancy remains an issue even with recurrent surges in COVID-19 cases due to new SARS-CoV-2 variants. Purpose: To elucidate psychosocial factors that contribute to our understanding of vaccine hesitancy. 676 Participants in Singapore took part in an online survey on vaccine hesitancy and uptake between May and June 2021. Data on demographics, perception of the COVID-19 pandemic, and vaccine willingness and hesitancy factors were collected. The responses were analyzed using structural equation modeling (SEM). The study found that confidence in the COVID-19 vaccines and risk perception of the COVID-19 situation are significantly associated with vaccination intention, while vaccination intention is also significantly associated with reported vaccination status. Additionally, certain chronic medical conditions moderate the relationship between vaccine confidence/risk perception and vaccine intention. This study contributes to our understanding of factors behind vaccination uptake which can help anticipate challenges to future vaccination campaigns for the next pandemic.