bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated skin lesion detection and classification using fused deep convolutional neural network on dermoscopic images
Authors: Priyanka Pramila Rayappa , Subhashini Radhakrishnan 
Published: July 2023

AbstractSkin cancer becomes a deadly disease that affect people of all ages globally. The availability of various types of benign and malignant melanoma makes the skin lesion diagnostic process difficult. Since the visual inspection of skin cancer is costlier and lengthy process, it is needed to design automatic diagnosis model to classify skin lesions accurately and promptly. Computer‐aided diagnosis models can be employed to identify the presence of skin lesions using dermoscopic images. The automatic identification of skin lesions can assist the doctors and enable the detection process at an efficient and faster rate. With this motivation, this article presents an automated skin lesion detection and classification using fused deep convolutional neural network (ASDC‐FDCNN) on dermoscopic images. The ASDC‐FDCNN technique aims to identify the existence of skin lesions from dermoscopic images. The ASDC‐FDCNN model involves the design of two deep learning models namely VGG19 and ResNet152 models. Besides, the fusion based feature extraction process is performed to derive feature vectors. In addition, the DCNN technique was employed as classifier for identifying the presence or absence of skin lesions. The performance validation of the ASDC‐FDCNN technique takes place utilizing benchmark skin lesion dataset. A comparative results analysis reported the better performance of the ASDC‐FDCNN model over the recent technique with respect to various measures.
The impact of indigenous culture and business group affiliation on corporate governance of African firms
Authors: Hearn Bruce , Oxelheim Lars , Randøy Trond 
Published: July 2023

AbstractResearch Question/IssueThis is a study of the relationship between business group ownership and constituent firms' adoption of Anglo‐American shareholder value governance in African firms at the undertaking of an initial public offering (IPO).Research Findings/InsightsWe find business group ownership to be associated with lower Anglo‐American corporate governance adoption by constituent firms. However, this association is reversed in the institutional context of higher tribalism, while correspondingly being exacerbated in the context of lower tribalism.Theoretical/Academic ImplicationsWe theorize that the influence of business group ownership on firms' adoption of Anglo‐American corporate governance is better understood when considering the institutional context. We highlight how informal cultural institutions are heterogeneous and thus shape the indigenous political economy and impact business groups. Specifically, we argue institutional contexts with higher tribalism are associated with more in‐group favoritism and nepotism. This association makes it critical for business group constituent firms to escape the constraints of the political economy of tribalism when attracting outside funding, leading to a higher inclination to adopt Anglo‐American governance. Contrastingly, in lower tribalism contexts, there is more universal trust across societies and an increased availability of domestic funding.Practitioner/Policy ImplicationsGiven the proliferation of business group ownership within economies worldwide, the study provides a useful framework with which to gauge the influence of business group ownership on a constituent firm's adoption of Anglo‐American governance best practice. In particular, the study emphasizes that the interdependence of formal institutional architecture and tribalism—both fundamentally associated with the demographic shape and with the incentive structures embedded within the underlying national political economy—calls for careful considerations when making national corporate governance recommendations.
Risk factors for the recurrence in pulmonary tuberculosis patients with massive hemoptysis
Authors: Lin Qiong , Chen Jian , Yu Tianxing , Gao Bing , Kuang Kaijin , Fan Yong , Xu Junping , Li Xiaohua , Lin Xin , Xu Liyu 
Published: July 2023

AbstractObjectivesTo evaluate the outcomes of bronchial artery embolization (BAE) for the treatment of massive hemoptysis in patients with pulmonary tuberculosis and identify risk factors that influence recurrence.MethodsA total of 81 patients with massive hemoptysis who underwent BAE between January 2014 and December 2017 were retrospectively reviewed. All of the patients had either a history of pulmonary tuberculosis or a current diagnosis of pulmonary tuberculosis. Follow‐up ranged from 18 to 66 months.ResultsHemoptysis was stopped or markedly decreased, with subsequent clinical improvement in 73 patients, while 11 patients experienced recurrence during the follow‐up period. Systemic‐pulmonary shunts and clinical failure showed a statistically significant correlation with the recurrence rate. The cumulative non‐recurrence rate was 95.3% for 3 months and 81.9% for more than 24 months. Complications were common (12.5%), but self‐limiting.ConclusionsBAE is a safe and effective treatment option for the control of massive hemoptysis in pulmonary tuberculosis patients. Systemic‐pulmonary shunts and clinical failure are the risk factors for recurrence.
Prior SARS‐CoV‐2 infection may not alter the clinical course of COVID‐19 in lung transplant recipients: A single‐center experience
Authors: Sindu Devika , Razia Deepika , Grief Katherine , Cherrier Lauren , Omar Ashraf , Walia Rajat , McAnally Kendra , Buddhdev Bhuvin , Tokman Sofya 
Published: July 2023

AbstractBackgroundIn the general population, prior infection with SARS‐CoV‐2 reduces the risk of severe COVID‐19; however, studies in lung transplant recipients (LTRs) are lacking. We sought to describe the clinical course of COVID‐19 recurrence and compare outcomes between the first and second episodes of COVID‐19 in LTRs.MethodsWe conducted a retrospective, single‐center cohort study of LTRs with COVID‐19 between January 1, 2022, and September 30, 2022, during the Omicron wave. We compared the clinical course of a second episode of COVID‐19 to that of the patients’ own first episode and to that of LTRs who developed a first episode during the study period.ResultsDuring the study period, we identified 24 LTRs with COVID‐19 recurrence and another 75 LTRs with a first episode of COVID‐19. LTRs who survived the initial episode of COVID‐19 had a similar disease course with recurrence, with a trend toward reduced hospitalization (10 (41.6%) vs. 4 (16.7%), p = .114). Furthermore, compared to LTRs with a primary infection during the Omicron wave, those with a reinfection had a non‐statistically significant trend toward reduced hospitalizations (aOR .391, 95% CI [.115–1.321], p = .131), shorter lengths‐of‐stay (median, 4 vs. 9 days, p = .181), and reduced intensive care unit admissions, intubations, and COVID‐19–related mortality.ConclusionsLTRs who survive the first episode of COVID‐19 are likely to have a similar clinical course with recurrent episodes. Although recurrent COVID‐19 may be milder, larger, well‐powered studies are needed to confirm this observation. Ongoing precautions are warranted.
A phase I study comparing the pharmacokinetics and safety of HS628 (tocilizumab biosimilar) and reference tocilizumab in healthy male subjects
Authors: Qian Hongjie , Cheng Jie , Gui Yuzhou , Wang Wei , Liang Liyu , Zhu Huijuan , Wu Qingqing , Ou Meixian , Chen Qian , Yu Chen , Jia Jingying 
Published: July 2023

AbstractThis study aimed to evaluate the pharmacokinetic (PK) similarity of the proposed biosimilar HS628 compared with the reference tocilizumab (Actemra®) and also to demonstrate similar safety and immunogenicity profiles in healthy Chinese male subjects. Eighty eligible subjects were randomized into two treatment groups in a 1:1 ratio to receive a single intravenous infusion of HS628 or tocilizumab at 4 mg/kg over 60 min. Blood samples were collected at the scheduled time points for PK and immunogenicity analysis. PK biosimilarity was determined using the standard bioequivalence criteria 80%–125%. A total of 77 subjects received the study drug and completed the study. The main PK parameters were similar for the test and reference groups. The ratio of geometric least‐squares means (GMR) and its 90% CIs for AUC0–t, AUC0–∞, and Cmax between the test group and reference group were 1.06 (1.00–1.12), 1.07 (1.00–1.14), and 1.04 (0.99–1.10), respectively, which were fully within the predefined bioequivalent range of 80%–125%. The incidence of treatment‐emergent adverse events (TEAEs) was similar for HS628 and tocilizumab (p > 0.05). The most common TEAEs were decreased fibrinogen, decreased neutrophils, pharyngalgia, oral ulcer, decreased leukocytes, and increased erythrocyte sedimentation rate. The results of the present study provide strong evidence to support the PK similarity and bioequivalence of HS628 and tocilizumab. The safety and immunogenicity profiles of HS628 were also shown to be similar to those of the reference tocilizumab.
Prevalence and associated factors of sexual dysfunction in premenopausal women with type 1 diabetes: A systematic review and meta‐analysis
Authors: Hashim Rahab , Forde Rita , Ausili Davide , Forbes Angus 
Published: July 2023

AbstractBackgroundSexual dysfunction (SD) in women with diabetes is a multifaceted complication driven by hormonal, neuropathic and psychosocial factors. It has been reported that the prevalence of SD is higher in women with type 1 diabetes compared to both women with type 2 diabetes and women without diabetes. However, prevalence estimates of SD in women with type 1 diabetes are variable, due to the heterogeneity of the conducted studies and the various confounding factors that are associated with SD.AimThis review aimed to estimate the prevalence of SD in premenopausal women with type 1 diabetes compared to women without diabetes; consider current methods for measuring SD; and identify factors associated with SD in women with type 1 diabetes.MethodA systematic review of the literature was conducted. Four electronic databases (Embase, MEDLINE, CINAHL, PsycINFO) were searched between 15 March and 29 April 2022, the search was updated on 4 February 2023 to identify studies that assessed SD in women with type 1 diabetes.FindingsThe search yielded in 1104 articles; of these, 180 were assessed for eligibility. A meta‐analysis of eight eligible studies revealed that the odds of experiencing SD is three times higher in women with type 1 diabetes compared to women without diabetes (OR = 3.8 95%CI 1.8–8.0, p < 0.001). The most commonly used measure of SD was the female sexual function index (FSFI); in three studies, this was combined with the female sexual distress scale (FSDS). Factors that have shown significant association with SD are depression, anxiety and duration of diabetes.ConclusionThis review has shown that SD is a significant issue for women with type 1 diabetes. These findings should encourage diabetes professionals and policymakers to give more attention to female SD (FSD) by incorporating it into care pathways and clinical guidelines.
Integrated person‐ and people‐centred primary care for diabetes in low‐ and middle‐income countries: The nurses' perspective on patient needs
Authors: Leyns Christine Cecile , Stilma Memelink Doriene , Bullinga Laura , De Maeseneer Jan , Willems Sara , Campman Melssen Carlijn 
Published: July 2023

AbstractAimsThe aim of this study was to identify what nurses working in primary care settings perceive as necessary to support the life needs of people with type 2 diabetes. Articulate these needs with the needs expressed by people with diabetes in a previous study. Finally, illustrate the potential of the used method.DesignA highly structured qualitative group method for brainstorming and idea sharing was used to generate a participant‐owned concept map that can support and evaluate practice change.MethodsData were collected between April and May 2022 in two public primary healthcare centres in Sacaba, Bolivia, with 33 professional nurses, technical nurses, nurse trainees and one physician. The concept mapping process by Trochim was used to generate, share and structure ideas, maximizing equality of input.ResultsThe nurses identified 73 unique needs that were structured in 11 conceptual clusters related to four different stakeholders or domains: organization of care and health policy, strengthening knowledge, skills and attitudes of healthcare providers, empower people living with diabetes and their family, and community‐level health promotion and diabetes education.ConclusionThe needs and domains identified by nurses and people with type 2 diabetes are very similar and inform a multisectoral and transdisciplinary action plan to jointly monitor and evaluate progress towards people‐centred care for people with diabetes.ImpactThis study demonstrates nurses' important contribution to analysing and designing people‐centred care in their community. They identify and act upon social determinants of health related to schools, safety and legislation. Besides global relevance, results inform the municipal health plan and an ongoing research project on cardiometabolic health.Patient or Public ContributionData from prior patient consultations were included in the study design, and study results inform the municipal health plan.
Improving oral hygiene for better cognitive health: Interrelationships of oral hygiene habits, oral health status, and cognitive function in older adults
Authors: Yang Yajie , Liang Lizhu , Cai Jinfen , You Jie , Liao Xiaoyan 
Published: July 2023

AbstractObjectivesTo explore the interrelationships between oral hygiene habits, oral health status and cognitive function in older adults.DesignA cross‐sectional study.Setting and ParticipantsA total of 371 participants (age 76.79 [7.99] years) were enrolled from June 2020 to November 2021 in an aged care facility.MethodsCognitive function was screened using the mini‐mental state examination (MMSE) with adjusted cut‐off points for age and education. Periodontal status (Biofilm‐Gingival Interface index based on periodontal probing depth and bleeding on probing), dental status (plaque, calculus, and caries), and tooth loss were assessed through full‐mouth examination. Oral hygiene habits were based on self‐ or informant‐reporting.ResultsPoor periodontal status was an associated factor for MCI (OR = 2.89, 95% CI = 1.20–6.95), while multiple tooth loss (OR = 4.90, 95% CI = 1.06 ~ 22.59), brushing teeth less than once a day (OR = 2.88, 95% CI = 1.12 ~ 7.45) and delayed dental visits (OR = 2.45, 95% CI = 1.05 ~ 5.68) were associated factors for cognitive impairment. An indirect effect of brushing teeth ≥2 daily on MMSE score through periodontal status was observed only in older adults without cognitive impairment (Bootstrap‐corrected B = 0.17, 95%CI = 0.03 ~ 0.36, SE = 0.08, β = 0.08).Conclusions and ImplicationsAdequate toothbrushing might prevent cognitive decline indirectly by improving periodontal health only in older adults without cognitive impairment. Multiple tooth loss, infrequent toothbrushing, and delayed dental visits were associated factors for cognitive impairment. Nursing professionals and health care policymakers should advocate for the improvement of basic oral hygiene in older adults, and provide regular professional oral hygiene care for older adults with cognitive impairment.Patient or Public ContributionThe information on oral health habits of this study was based on an interview with the participants or their caregivers during the study period.
“Bringing and Removing Self from the Table”: Therapists’ use and management of eating disorder lived experience in the treatment of clients with eating disorders
Authors: King Ashley A. , Russon Jody M. 
Published: July 2023

AbstractTherapists report significant countertransference reactions when treating clients with eating disorders (EDs). Countertransference may be pronounced among therapists with eating disorder lived experience (EDLE). Minimal research examines how therapists with EDLE negotiate their experiences while treating ED clients. Informed by the person‐of‐the‐therapist philosophy, this study sought to understand how therapists use and manage their EDLE when working with ED clients. Using constructivist grounded theory methodology, semistructured interviews (Mtime = 89 min) were conducted with 22 therapists with EDLE. Results revealed that therapists engaged in two interconnected systems. The Central System helps therapists transform their lived experiences into clinical guidance. The Checks and Balances System allows therapists to find a balance between connecting with the client and allowing for differences in experiences to emerge. Lastly, three personal processes existing outside of these systems were found to impact therapists’ use of self. Findings provide novel ways that therapists can use their EDLE.
Adverse effects of gestational ω‐3 and ω‐6 polyunsaturated fatty acid imbalance on the programming of fetal brain development
Authors: Cinquina Valentina , Keimpema Erik , Pollak Daniela D. , Harkany Tibor 
Published: July 2023

AbstractObesity is a key medical challenge of our time. The increasing number of children born to overweight or obese women is alarming. During pregnancy, the circulation of the mother and her fetus interact to maintain the uninterrupted availability of essential nutrients for fetal organ development. In doing so, the mother's dietary preference determines the amount and composition of nutrients reaching the fetus. In particular, the availability of polyunsaturated fatty acids (PUFAs), chiefly their ω‐3 and ω‐6 subclasses, can change when pregnant women choose a specific diet. Here, we provide a succinct overview of PUFA biochemistry, including exchange routes between ω‐3 and ω‐6 PUFAs, the phenotypes, and probable neurodevelopmental disease associations of offspring born to mothers consuming specific PUFAs, and their mechanistic study in experimental models to typify signaling pathways, transcriptional, and epigenetic mechanisms by which PUFAs can imprint long‐lasting modifications to brain structure and function. We emphasize that the ratio, rather than the amount of individual ω‐3 or ω‐6 PUFAs, might underpin physiologically correct cellular differentiation programs, be these for neurons or glia, during pregnancy. Thereupon, the PUFA‐driven programming of the brain is contextualized for childhood obesity, metabolic, and endocrine illnesses.
Understanding the Link between Post‐Acquisition Resource Reconfiguration and Technology Out‐Licensing
Authors: Klueter Thomas Maximilian , Moreira Solon , Ofoedu Clinton 
Published: July 2023

AbstractWe develop a novel framework to explain how the unique properties of out‐licensing enable R&D reconfiguration in the context of technology acquisitions. Out‐licensing is an attractive R&D strategy following acquisitions as it expands opportunities for resource reconfiguration to outside the organization by using external partners while at the same time allowing firms to continue to benefit from the technology, both financially and strategically. We also propose that the positive relationship between technology acquisitions and out‐licensing is weaker when firms cannot determine the full value potential of their R&D due to uncertainty or when they have high availability of short‐term financial slack resources. Using a sample of bio‐pharmaceutical firms, the result of a 2SLS fixed‐effect regression that accounts for the potential endogeneity of technology acquisitions provides support for our theoretical framework.
Business Groups and Export Performance: The Role of Coordination Failures and Institutional Configurations
Authors: Shapiro Daniel , Estrin Saul , Carney Michael , Liang Zhixiang (Steven) 
Published: July 2023

AbstractWe explore the nature of business groups (BGs) and their affiliates in emerging markets through the lens of the coordination failures associated with economic development. We propose that BGs develop distinct economic and political capabilities that provide affiliates with access to the complementary resources required for successful exporting. We further argue that these capabilities are context‐specific, based on the market and political institutions of the home country. We propose that the BG advantage in supporting affiliate exporting increases as market institutions strengthen but is reduced (strengthened) as political systems become more democratic (autocratic). We apply Tobit estimation methods to a large sample of firms from emerging and developing countries at different stages of institutional development and find consistent evidence in favour of our hypotheses. We develop a framework to analyse alternative BG internationalization paths in a comparative institutional context.
The development and cognitive testing of a patient‐reported experience measure for patients with chronic pain of temporomandibular disorders
Authors: Taimeh Dina , Ni Riordain Richeal , Fedele Stefano , Leeson Rachel 
Published: July 2023

AbstractIntroductionThe importance of the patients' clinical experience has been reinforced several times over the last decade by healthcare organisations and policy makers. Routine gathering of experience data can help in enhancing patient‐centred care and provide guidance to quality improvement schemes. Patient‐reported experience measures can help to that end. The aim of this study was to develop a patient‐reported experience measure to evaluate the experience of patients with temporomandibular disorders while receiving healthcare.MethodsInput from several sources was utilised to develop the tool; previous literature, patients with temporomandibular disorders, and experts in the field. A qualitative study was conducted following the COnsensus‐based Standards for the selection of health Measurement Instruments guidance to generate the items of the questionnaire, which subsequently underwent cognitive testing.ResultsSeventeen patients took part in the qualitative study, in addition to six healthcare professionals. The preliminary questionnaire consisted of 28 questions with six response options.ConclusionsThis patient‐reported experience measure is a brief tool to evaluate the clinical experience of patients with temporomandibular disorders. Patients' involvement ensured face and content validity of the questionnaire, in addition to the relevance, comprehensibility and comprehensiveness of the items.