bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circ_0001666 upregulation promotes intestinal epithelial cell fibrosis in pediatric Crohn's disease via the SRSF1/BMP7 axis
Authors: Li Jun , Xu Ji‐Zhi , Dou Bo , Huang Teng‐Fei , Chen Jie , Wang Tuan‐Mei , Ouyang Hong‐Juan 
Published: August 2023

AbstractThe epithelial–mesenchymal transition (EMT) is closely associated with Crohn's disease (CD) related intestinal fibrosis, a condition whose prevalence is increasing annually among children. Recently, the CD marker gene microarray screening revealed an upregulation of circ_0001666 in the colon tissues of CD patients, but its underlying mechanisms remain unclear. In this study, we explored the molecular mechanism of circ_0001666 in regulating EMT‐mediated fibrosis in CD in vitro. The levels of circ_0001666 and EMT‐associated proteins were assessed in CD clinical samples, and a CD cell model was established using TGF‐β1 to induce human intestinal epithelial cells (HIECs). Additionally, the expression levels of genes and proteins related to EMT and fibrosis were analyzed by quantitative real‐time PCR and western blot, cell migration, and invasion were assessed via wound healing assay and transwell, respectively, and RNA pull‐down and RNA immunoprecipitation assays were performed to verify the relationship between SRSF1 and BMP7 or circ_0001666. Circ_0001666 was overexpressed in the intestinal mucosal tissues of CD patients and was positively correlated with EMT. Silencing circ_0001666 inhibited the migration, invasion, EMT, and fibrosis of HIECs induced by TGF‐β1. Mechanistically, circ_0001666 regulated BMP7 expression by interacting with SRSF1. Furthermore, the effects of inhibiting circ_0001666 on HIECs could be partially reversed by overexpressing SRSF1 or silencing BMP7. Collectively, circ_0001666 regulates TGF‐β1‐induced HIEC migration, invasion, EMT, and fibrosis. Circ_0001666 also promoted EMT‐mediated fibrosis by interacting with SRSF1 to accelerate BMP7 mRNA decay. These findings provide new insights into the pathogenesis of CD and suggest that circ_0001666 might be a potential therapeutic target for CD.
Prevalence of Voice Disorders in the United States: A National Survey
Authors: Huston Molly N. , Puka Ira , Naunheim Matthew R. 
Published: August 2023

ObjectivesThe prevalence of voice disorders has not been explored in the context of recent trends in voice use, including voice assistant technology and increased use of teleconferencing for remote work. The objective of this research is (1) to determine the prevalence of voice disorders in the adult population of the United States, and (2) to understand the association of voice disorders with demographic and voice use factors, including vocal demands, and use of teleconferencing and voice assistant technology.MethodsA survey pertaining to voice disorders and voice use was developed and administered to a representative sample of US population. Demographics and information related to risk factors for voice disturbance, including high vocal demands, teleconferencing, and voice‐assistant use were also analyzed.ResultsA total of 1522 responses were included. Of these, 20.6% reported having had a voice disorder at some point in their life. This rate was higher in employed respondents, singers, and teachers (all p < 0.0001) and was notably higher in those who used teleconferencing technology and voice assistant technology (both p < 0.0001). Approximately 60% of this subset reported seeking medical care for their voice, 12.6% reported a current voice disorder, and 9.5% reported a voice problem that had recurred multiple times.ConclusionsApproximately 1 in 5 Americans surveyed has had a voice disorder. Risk factors for voice disorders include use of teleconferencing technology, voice assistant use, and occupational factors.Level of Evidence3 Laryngoscope, 134:347–352, 2024
Developing a Novel Platelet‐Rich Plasma‐Laden Bioadhesive Hydrogel Contact Lens for the Treatment of Ocular Surface Chemical Injuries
Authors: Soykan Merve Nur , Altug Burcugul , Bas Harun , Ghorbanpoor Hamed , Avci Huseyin , Eroglu Sertac , Butun Sengel Sultan , Eker Sariboyaci Ayla , Gunes Bagis Sibel , Uysal Onur , Atalay Eray 
Published: August 2023

AbstractPermanent injury to corneal limbal stem cells after ocular surface chemical and thermal injuries is a major cause of corneal blindness. In this study, a PRP‐laden GelMA hydrogel contact lens is manufactured which is aimed to support the limbal niche after ocular surface insults thereby preventing limbal stem cell failure. GelMA with varying platelet‐rich plasma (PRP) concentrations (5%, 10%, and 20%) is photopolymerized using a visible light crosslinking system followed by characterizations of mechanical properties, growth factor release, enzymatic degradation, and in vitro cytotoxicity. The addition of 10% PRP into 10% GelMA hydrogel precursor solution results in the highest tensile and compressive modulus (38 and 110 kPa, respectively) and burst pressure (251±37.66 mmHg). Degradation time varies according to the concentration of the collagenase enzyme tested (0, 2.5, 5, and 40 µg/mL) and is most prolonged with 20% PRP. EGF and TGF‐β release profiles suggest an initial burst release followed by sustained release, most consistent in the 10% PRP sample. Although cell viability decreases on day 1, rapid recovery is observed and is approximately 120% after day 21. PRP‐laden GelMA in the form of a contact lens may be a promising biomaterial‐based treatment approach for the maintenance of limbal epithelial stem cells after ocular surface insults.
High Thermal Conductivity and Low Dielectric Constant of Polyesters Based on Fluorine and Mesogenic Unit
Authors: Wu Yifei , Wu Kun , Xiao Fei , Diao Wenjie , He Daguang , Yang Hui , Shi Jun 
Published: August 2023

AbstractHigh thermal conductivity polymeric dielectrics with advanced dielectric properties are urgently demanded in various applications. In this study, a series of thermoplastic polyesters containing different content of fluorine and mesogenic unit in main chains are synthesized utilizing polycondensation. The preferred orientation of liquid crystal can effectively inhibit phonon scattering, and the introduction of fluorine can reduce the polarizability of the polymer and increase the free volume. By introducing the biphenyl mesogenic unit and fluorine into the main chain, its thermal conductivity has been increased to 0.425 Wm−1k−1 from 0.183 Wm−1k−1(the polymer without liquid crystal element), which is 132% higher than that of the liquid crystal polymer without fluorine. In addition, the dielectric constant of polyester decreased to 2.97, and the dielectric loss drops to 8.74 × 10−4. The influence mechanism of two ways on its thermal and dielectric properties is explored. Good thermal conductivity and excellent dielectric properties make potential in the thermal management system and flexible electronics.
Borel complexity and Ramsey largeness of sets of oracles separating complexity classes
Authors: Creiner Alex , Jackson Stephen 
Published: August 2023

AbstractWe prove two sets of results concerning computational complexity classes. First, we propose a new variation of the random oracle hypothesis, originally posed by Bennett and Gill after they showed that relative to a randomly chosen oracle, with probability 1. Their original hypothesis was quickly disproven in several ways, most famously in 1992 with the result that , in spite of the classes being shown unequal with probability 1. Here we propose a variation of what it means to be “large” using the Ellentuck topology. In this new context, we demonstrate that the set of oracles separating and is not small, and obtain similar results for the separation of from along with the separation of from . We also show that the set of oraclesequatingwith is large in this new sense. We demonstrate that this version of the hypothesis provides a sufficient condition for unrelativized relationships, at least in the cases considered here. Second, we examine the descriptive complexity of the classes of oracles providing the separations for these various classes, and determine their exact placement in the Borel hierarchy.
On self‐distributive weak Heyting algebras
Authors: Nourany Mohsen , Ghorbani Shokoofeh , Saeid Arsham Borumand 
Published: August 2023

AbstractWe use the left self‐distributive axiom to introduce and study a special class of weak Heyting algebras, called self‐distributive weak Heyting algebras (SDWH‐algebras). We present some useful properties of SDWH‐algebras and obtain some equivalent conditions of them. A characteristic of SDWH‐algebras of orders 3 and 4 is given. Finally, we study the relation between the variety of SDWH‐algebras and some of the known subvarieties of weak Heyting algebras such as the variety of Heyting algebras, the variety of basic algebras, the variety of subresiduated lattices, the variety of reflexive WH‐algebras (RWH‐algebras), and the variety of transitive WH‐algebras (TWH‐algebras).
A note on commutators of singular integrals with BMO and VMO functions in the Dunkl setting
Authors: Dziubański Jacek , Hejna Agnieszka 
Published: August 2023

AbstractOn equipped with a root system R, multiplicity function , and the associated measure , we consider a (nonradial) kernel , which has properties similar to those from the classical theory of singular integrals and the Dunkl convolution operator associated with K. Assuming that b belongs to the BMO space on the space of homogeneous type , we prove that the commutator is a bounded operator on for all . Moreover, is compact on , provided . The paper extends results of Han, Lee, Li, and Wick.
Unfolding the Correlation between Solution Aggregation and Solid‐State Crystal Orientation in Donor–Acceptor Copolymers via Solvent Additive Processing
Authors: Li Dingke , Zhao Qingqing , Zheng Hao , Peng Juan 
Published: August 2023

AbstractTailoring the crystal orientation of donor–acceptor (D–A) copolymers is vital for boosting the performance of optoelectronic devices. Despite recent advances in controlling the crystal orientation of D–A copolymers in films, the investigation into their aggregates in solution and the correlation between the solution aggregates and solid‐state crystal orientation has been limited. Herein, an effective solvent additive strategy is reported for tuning solution aggregates and the consequent solid‐state structures of poly{[N,N'‐bis(2‐octyldodecyl)‐naphthalene‐1,4,5,8‐bis(dicarboximide)‐2,6‐diyl]‐alt‐5,5′‐(2,2′‐bithiophene)} (P(NDI2OD‐T2)). Specifically, the addition of 1‐decanethiol (10‐thiol) to the P(NDI2OD‐T2) chloroform solution promoted the aggregation of P(NDI2OD‐T2) chains because of the improved planarization of the backbones, which changed their crystal orientation in the film from coexisting edge‐on and face‐on to dominant edge‐on when produced by drop‐casting. The mechanism of this crystal orientation transformation is elucidated based on the interaction between 10‐thiol and the side chains of P(NDI2OD‐T2). The optical properties of P(NDI2OD‐T2) films with different crystalline structures are closely correlated. Notably, the 10‐thiol‐enabled facile tailoring of the crystal orientation in P(NDI2OD‐T2) can be readily applied to other D–A copolymers of interest. The findings of this study highlight a robust solvent additive strategy for regulating solution aggregates and crystal orientation in D–A copolymer films, which have applications in many optoelectronic devices.
Molecular subtypes identified by multiomics analysis based on cuproptosis‑related genes precisely predict response to immunotherapy and chemotherapy in colorectal cancer
Authors: Li Dingling , Gao Wenxing , Zhao Wen , Zhao Yingjie , Zhang Yanfei , Liu Ying , Li Yuying , Ji Shuaifei , Chen Peng , Li Dingchang 
Published: August 2023

AbstractCuproptosis is a newly reported type of programmed cell death that is involved in the progression of various diseases. Some studies have reported its potential significance in multiple tumors. Colorectal cancer (CRC) is one of the malignant tumors with high incidence and mortality. The purpose of this study was to further explore the importance of cuproptosis in the CRC development and treatment. We analyzed the expression, alterations, and promoter methylation of cuproptosis‑related genes (CRGs) in patients with CRC. Three machine learning methods was used to determine cuproptosis‐related feature genes and a diagnostic model was built based on them. Using the unsupervised clustering, patients with CRC were classified into distinct clusters. Then, the LASSO method was used to establish a cuproptosis risk model. We analyzed the association of risk scores with outcomes, immune microenvironment, response to immunotherapy, and sensitivity to chemotherapeutic drugs. The results showed that the expression of CRGs was dysregulated in CRC. The diagnostic model based on cuproptosis‐related feature genes showed great clinical value. The patients in two clusters displayed different prognosis and microenvironment. Furthermore, the risk score was correlated with clinical characteristics, immune infiltration and response to immunotherapy and chemotherapy. Above all, the present findings revealed the involvement of cuproptosis in CRC development and provided a diagnostic tool to evaluate CRC occurrence risk. The immune infiltration and drug sensitivity analysis results helped to predict the response of patients in different subtypes of CRC to immunotherapy and chemotherapy.
Identifying blocking behaviors in small‐scale group decision‐making and their impact on consensus outcomes: A case study on forest management
Authors: Enjolras Manon , Arnould Maxence , Camargo Mauricio 
Published: August 2023

AbstractGroup decision‐making (GDM) problems usually include stakeholders with different views and opinions. In order to find a collective solution, it is necessary to achieve a consensus reaching process (CRP) that may lead to the emergence of non‐cooperative behaviors within the group. This article proposes to study how these non‐cooperative behaviors appear in a group of decision‐makers and what their level of impact is on the evolution of consensus and on the final decision. To provide some answers to this research problem, we propose a multi‐criteria decision‐making (MCDM) methodology implementing analytic hierarchy process (AHP) in order to provide a visualization of the CRP evolution and observe four non‐cooperative behaviors within small‐scale GDM: (1) collective agreement, (2) blocking behavior, (3) leadership demonstration, and (4) experts' coalition. We implement our methodology within a pedagogical framework, in 29 small‐scale groups of masters and engineering students, through a case study related to the implementation of forest management scenarios in France. Our results show the evolution of the four non‐cooperative behaviors within the groups, as well as their impact on the CRP outcomes.
MultiIB‐TransUNet: Transformer with multiple information bottleneck blocks for CT and ultrasound image segmentation
Authors: Li Guangju , Jin Dehu , Yu Qi , Zheng Yuanjie , Qi Meng 
Published: August 2023

AbstractBackgroundAccurate medical image segmentation is crucial for disease diagnosis and surgical planning. Transformer networks offer a promising alternative for medical image segmentation as they can learn global features through self‐attention mechanisms. To further enhance performance, many researchers have incorporated more Transformer layers into their models. However, this approach often results in the model parameters increasing significantly, causing a potential rise in complexity. Moreover, the datasets of medical image segmentation usually have fewer samples, which leads to the risk of overfitting of the model.PurposeThis paper aims to design a medical image segmentation model that has fewer parameters and can effectively alleviate overfitting.MethodsWe design a MultiIB‐Transformer structure consisting of a single Transformer layer and multiple information bottleneck (IB) blocks. The Transformer layer is used to capture long‐distance spatial relationships to extract global feature information. The IB block is used to compress noise and improve model robustness. The advantage of this structure is that it only needs one Transformer layer to achieve the state‐of‐the‐art (SOTA) performance, significantly reducing the number of model parameters. In addition, we designed a new skip connection structure. It only needs two 1× 1 convolutions, the high‐resolution feature map can effectively have both semantic and spatial information, thereby alleviating the semantic gap.ResultsThe proposed model is on the Breast UltraSound Images (BUSI) dataset, and the IoU and F1 evaluation indicators are 67.75 and 87.78. On the Synapse multi‐organ segmentation dataset, the Param, Hausdorff Distance (HD) and Dice Similarity Cofficient (DSC) evaluation indicators are 22.30, 20.04 and 81.83.ConclusionsOur proposed model (MultiIB‐TransUNet) achieved superior results with fewer parameters compared to other models.
A temperature‐controlled cooling system for accurate quantitative post‐mortem MRI
Authors: Rieger Sebastian W. , Hess Aaron , Ji Yang , Rodgers Christopher T. , Jezzard Peter , Miller Karla L. , Wu Wenchuan 
Published: August 2023

AbstractPurposeTo develop a temperature‐controlled cooling system to facilitate accurate quantitative post‐mortem MRI and enable scanning of unfixed tissue.MethodsA water cooling system was built and integrated with a 7T scanner to minimize temperature drift during MRI scans. The system was optimized for operational convenience and rapid deployment to ensure efficient workflow, which is critical for scanning unfixed post‐mortem samples. The performance of the system was evaluated using a 7‐h diffusion MRI protocol at 7T with a porcine tissue sample. Quantitative T1, T2, and ADC maps were interspersed with the diffusion scans at seven different time points to investigate the temperature dependence of MRI tissue parameters. The impact of temperature changes on biophysical model fitting of diffusion MRI data was investigated using simulation.ResultsTissue T1, T2, and ADC values remained stable throughout the diffusion MRI scan using the developed cooling system, but varied substantially using a conventional scan setup without temperature control. The cooling system enabled accurate estimation of biophysical model parameters by stabilizing the tissue temperature throughout the diffusion scan, while the conventional setup showed evidence of significantly biased estimation.ConclusionA temperature‐controlled cooling system was developed to tackle the challenge of heating in post‐mortem imaging, which shows potential to improve the accuracy and reliability of quantitative post‐mortem imaging and enables long scans of unfixed tissue.
Head‐to‐Head Comparison of ChatGPT Versus Google Search for Medical Knowledge Acquisition
Authors: Ayoub Noel F. , Lee Yu‐Jin , Grimm David , Divi Vasu 
Published: August 2023

AbstractObjectiveChat Generative Pretrained Transformer (ChatGPT) is the newest iteration of OpenAI's generative artificial intelligence (AI) with the potential to influence many facets of life, including health care. This study sought to assess ChatGPT's capabilities as a source of medical knowledge, using Google Search as a comparison.Study DesignCross‐sectional analysis.SettingOnline using ChatGPT, Google Seach, and Clinical Practice Guidelines (CPG).MethodsCPG Plain Language Summaries for 6 conditions were obtained. Questions relevant to specific conditions were developed and input into ChatGPT and Google Search. All questions were written from the patient perspective and sought (1) general medical knowledge or (2) medical recommendations, with varying levels of acuity (urgent or emergent vs routine clinical scenarios). Two blinded reviewers scored all passages and compared results from ChatGPT and Google Search, using the Patient Education Material Assessment Tool (PEMAT‐P) as the primary outcome. Additional customized questions were developed that assessed the medical content of the passages.ResultsThe overall average PEMAT‐P score for medical advice was 68.2% (standard deviation [SD]: 4.4) for ChatGPT and 89.4% (SD: 5.9) for Google Search (p < .001). There was a statistically significant difference in the PEMAT‐P score by source (p < .001) but not by urgency of the clinical situation (p = .613). ChatGPT scored significantly higher than Google Search (87% vs 78%, p = .012) for patient education questions.ConclusionChatGPT fared better than Google Search when offering general medical knowledge, but it scored worse when providing medical recommendations. Health care providers should strive to understand the potential benefits and ramifications of generative AI to guide patients appropriately.
Preparation and properties of silane coupling agent modified vermiculite and its composite films
Authors: Pei Meng , Shang Xiaoyu , Xu Yuhuan , Zhang Daohai 
Published: August 2023

AbstractVermiculite (VMT) was used as a filler and it was modified with silane coupling agent KH570 to produce OVMT. VMT/PBAT and OVMT/PBAT composite films were prepared using the solution method using polybutylene terephthalate (PBAT) as a matrix. The structure, thermal properties, crystalline properties, rheological properties, cross‐sectional microstructure, and tensile properties and antibacterial properties of the pure PBAT film, VMT/PBAT, and OVMT/PBAT composite films were tested, including comparative analysis. The results showed that VMT was successfully modified with silane coupling agent to produce OVMT. Furthermore, the thermal stability of VMT/PBAT and OVMT/PBAT composite films decreased compared with pure PBAT film. As the content of VMT and OVMT increases, the energy storage modulus and loss modulus of VMT/PBAT and OVMT/PBAT composite films increase, while the loss factor, complex viscosity and crystallinity gradually decrease. Additionally, the tensile strength and elongation at break of VMT/PBAT and OVMT/PBAT composite films decrease. All three films had no effect on Staphylococcus aureus or Escherichia coli. The modification of VMT with the silane coupling agent KH570 improved the compatibility of OVMT with PBAT, resulting in improved mechanical properties of the OVMT/PBAT composite film compared with the VMT/PBAT composite film. The mechanical properties of the OVMT/PBAT‐20% composite film increased by 35.9% in tensile strength and 10.8% in elongation at break compared with the VMT/PBAT‐20% composite film.Highlights
VMT successfully modified with silane coupling agent to produce OVMT.
The modification promotes the compatibility of the filler with PBAT.
VMT modification helps to improve the mechanical properties of composite materials.
Vermiculite modification helps to improve the toughness of composite materials.
Prenatal diagnosis of bilateral anophthalmia: Identifying de novo SOX2 variant
Authors: Kidd Jennifer , Patberg Elizabeth , McGath Meghan , Monteleone Berrin , Chavez Martin 
Published: August 2023

AbstractA 26 year old nulligravida presented at 24 weeks gestation for the second opinion of abnormal fetal profile and mid‐face views on ultrasound at another institution. A detailed fetal anatomic ultrasound at our facility revealed the absence of fetal lens and globes bilaterally consistent with bilateral anophthalmia (HP: 0000528) without other anomalies. Karyotype and chromosomal microarray analysis were completed from amniocentesis sample. After these results, duo exome testing with paternal sequencing was completed from proband amniotic fluid sample and parental blood samples. A pathogenic variant in SOX2 (NM_003106.3: c.513C>G p.(Tyr171*Ter)) with heterozygous autosomal dominant inheritance resulted. On duo exome testing with paternal segregation analysis, the variant was found to be consistent with likely sporadic de novo inheritance. The SOX2 variant reported is consistent with the fetal phenotype in this case. While germline mosaicism could exist, this identified variant provided the family with a likely explanation for this proband's finding. This ultrasound and genetic testing allowed the family to make decisions related to planning in current and future pregnancies.