bluuebunny/crossref_metadata_2025_split huggingface dataset:
Body Integrity Dysphoria and “Just” Amputation: State-of-the-Art and Beyond
Authors: Loriga Leandro 
Published: March 2023

Abstract
This paper presents the foundation upon which the contemporary knowledge of body integrity dysphoria (BID) is built. According to the World Health Organisation’s International Classification of Diseases, 11th edition (ICD-11), the main feature of BID is an intense and persistent desire to become physically disabled in a significant way. Three putative aetiologies that are considered to explain the insurgence of the condition are discussed: neurological, psychological and postmodern theories. The concept of bodily representation within the medical context is highlighted, with the concept of dysphoria, which was brought to the fore with the introduction of the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), and the ICD-11. Contemporary issues of “justice” are addressed to identify ethically relevant distinctions between BID and sex reassignment surgery. It is argued that there is no ethically relevant difference between the BID actor’s desire for invasive surgical intervention and the wish of gender dysphoric individuals to undergo sex reassignment surgery procedures. Some BID actors self-mutilate, and this presents medical professionals with difficult choices regarding whether or not to intervene in order to satisfy the BID patient’s desire. Both abstention and intervention may lead to severe ethical complications for doctors and patients despite the positive outcomes in terms of quality of life for BID individuals who manage to undergo such procedures.
Presentation, management and outcomes of iliopsoas abscess at a University Teaching Hospital in Nepal
Authors: Sah Jayant Kumar , Adhikari Shankar , Sah Ganesh , Ghimire Bikal , Singh Yogendra Prasad 
Published: March 2023

Abstract

Objectives
Iliopsoas abscess (IPA) is an uncommon clinical disease and is often missed to diagnose due to vague clinical presentation. Early treatment with drainage and appropriate antibiotic therapy is necessary before sepsis sets in and become lethal. We conducted this study to evaluate clinical features, etiology, management strategies, and outcomes in patients with IPA from a University Teaching Hospital in Nepal.

Methods
A retrospective analysis of 32 consecutive IPA cases managed at Tribhuvan University Teaching Hospital, Nepal for the period of January 2019 to February 2022 was carried out.

Results
The mean age was 42.5 ± 19.1 years (range, 19–75 years) and the male: female ratio was 2.2:1. Two-thirds or more patients presented with fever, limp, fixed flexion deformity and/or low back pain. Ultrasonography (US) was diagnostic in 27 (84.4%) patients. Eighteen (56.3%) patients had primary IPAs, and 14 (43.7%) had secondary IPAs. Thirty (93.7%) patients were managed with US guided percutaneous drainage (PCD) and 2 (6.2%) patients underwent open surgical drainage. Drainage procedures were combined with antibiotics in all patients. Pus culture showed Staphylococcus aureus growing in the majority of cases (10 of 23, 43.5%). The hospital stay was longer in patients treated via surgical drainage compared to those who received PCD: 13 days (range 12–14 days) vs. 6.6 days (range 4–13 days), respectively. Recurrence of abscess was seen in 4 (12.5%) cases and all were successfully managed via a second PCD. There was no mortality.

Conclusions
Varying clinical presentation of iliopsoas abscess demand a high index of suspicion for early diagnosis. Initial imaging modality in suspected case of IPA is US. US-guided PCD along with the appropriate antibiotics is a successful frontline treatment of IPAs with shorter hospital stay.
New non-augmented mixed finite element methods for the Navier–Stokes–Brinkman equations using Banach spaces
Authors: Gatica Gabriel N. , Núñez Nicolás , Ruiz-Baier Ricardo 
Published: March 2023

Abstract
In this paper we consider the Navier–Stokes–Brinkman equations, which constitute one of the most common nonlinear models utilized to simulate viscous fluids through porous media, and propose and analyze a Banach spaces-based approach yielding new mixed finite element methods for its numerical solution. In addition to the velocity and pressure, the strain rate tensor, the vorticity, and the stress tensor are introduced as auxiliary unknowns, and then the incompressibility condition is used to eliminate the pressure, which is computed afterwards by a postprocessing formula depending on the stress and the velocity. The resulting continuous formulation becomes a nonlinear perturbation of, in turn, a perturbed saddle point linear system, which is then rewritten as an equivalent fixed-point equation whose operator involved maps the velocity space into itself. The well-posedness of it is then analyzed by applying the classical Banach fixed point theorem, along with a smallness assumption on the data, the Babuška–Brezzi theory in Banach spaces, and a slight variant of a recently obtained solvability result for perturbed saddle point formulations in Banach spaces as well. The resulting Galerkin scheme is momentum-conservative. Its unique solvability is analyzed, under suitable hypotheses on the finite element subspaces, using a similar fixed-point strategy as in the continuous problem. A priori error estimates are rigorously derived, including also that for the pressure. We show that PEERS and AFW elements for the stress, the velocity, and the rotation, together with piecewise polynomials of a proper degree for the strain rate tensor, yield stable discrete schemes. Then, the approximation properties of these subspaces and the Céa estimate imply the respective rates of convergence. Finally, we include two and three dimensional numerical experiments that serve to corroborate the theoretical findings, and these tests illustrate the performance of the proposed mixed finite element methods.
Numerical investigations of flow in nuclear fuel assembly with spacer grid and OpenFOAM validation
Authors: Mistry Hemish 
Published: March 2023

Abstract
Spacer grids with mixing vanes have complex geometry and are used to support the fuel rods in nuclear fuel assemblies as well as to improve heat transfer by generating turbulence downstream of the spacer grid in the cores of the pressurized water reactors. To validate the CFD code OpenFOAM for relevant spacer grid geometries, numerical analyses on the OECD/NEA MATiS-H benchmark were performed. The flow behind two different types of spacer grid designs was analysed: split- and swirl-type. Initially, an appropriate inlet velocity profile was generated. In a next step, Computer-Aided Design models of the spacer grids were prepared and then meshed using ANSYS Mesher 19.2. Transient URANS simulations were performed with the k-ω-SST turbulence model and the results were compared with data. Good agreement was obtained for the mean velocity profile and the vorticity in the swirl-type configuration, while the numerical results slightly overestimated the transverse velocity profile at some measurements locations of the split-type configuration.
The content of this article was initially presented at the 33rd German CFD Network of Competence Meeting, held on March 22–23 at GRS in Garching, Germany.
Electrically tunable THz graphene metasurface wave retarders
Authors: Park Hyunwoo , Jeong Sodam , Seo Changwon , Park Hyeongi , Oh Donghak , Shim Jae-Eon , Lee Jaeyeong , Ha Taewoo , Kim Hyeon-Don , Baek Soojeong , Min Bumki , Kim Teun-Teun 
Published: March 2023

Abstract
Anisotropic materials with chirality or birefringence can be used to manipulate the polarization states of electromagnetic waves. However, the comparatively low anisotropy of natural materials hinders the miniaturization of optical components and devices at terahertz frequencies. In this study, we experimentally demonstrate that the relative phase retardation of a THz wave can be electrically controlled by integrating patterned mono- and bilayer graphene onto an otherwise isotropic metasurface. Specifically, we show that a refractive index for one of the orthogonal polarization states can be electrically controlled by modulating graphene’s conductivity, thereby weakening the capacitive coupling between adjacent meta-atoms in an anisotropic manner. With monolayer graphene, phase retardation of 15° to 81° between two orthogonal polarization states can be achieved. Maximum phase retardation of 90° through a metasurface with bilayer graphene suggests its use as a tunable quarter-wave plate. Continuous control from linear- to circular-polarization states may provide a wide range of opportunities for the development of compact THz polarization devices and polarization-sensitive THz technology.
Super-gain nanostructure with self-assembled well-wire complex energy-band engineering for high performance of tunable laser diodes
Authors: Wang Yuhong , Tai Hanxu , Duan Ruonan , Zheng Ming , Lu Wei , Shi Yue , Zhang Jianwei , Zhang Xing , Ning Yongqiang , Wu Jian 
Published: March 2023

Abstract
Although traditional quantum-confined nanostructures e.g. regular quantum wells or quantum dots have achieved huge success in the field of semiconductor lasers for past decades, these traditional nanostructures are encountering the difficulty of enhancing device performance to a higher level due to their inherent gain bottleneck. In this paper, we are proposing a new super-gain nanostructure based on self-assembled well-wire complex energy-band engineering with InGaAs-based materials to break through the existing bottleneck. The nanostructure is constructed by utilizing the special strain-driven indium (In)-segregation and the growth orientation-dependent on-GaAs multi-atomic step effects to achieve the distinguished ultra-wide and uniform super-gain spectra. The structural details and its luminescence mechanism are investigated by multiple measurement means and theoretical modeling. The polarized gain spectra with the max fluctuation of <3 cm−1 in 904 nm–998 nm for transverse electric (TE) mode and 904 nm–977 nm for transverse magnetic (TM) mode are simultaneously obtained with this nanostructure. It enables an ultra-low output power fluctuation of <0.7 dB and a nearly-constant threshold power throughout an ultra-wide wavelength range under a fixed injection level. It was difficult to realize these in the past. Therefore, the described super-gain nanostructure brings a brand-new chance of developing high performance of tunable laser diodes.
Modulatory effects of ergothioneine on behavioural responses of Arabian stallions following a 2,000 m race during the rainy and hot-dry seasons in a tropical environment
Authors: Adah Adakole S. , Ayo Joseph O. , Rekwot Peter I. , Aluwong Tagang , Adah Deborah A. 
Published: March 2023

Abstract
Experiments were performed to determine the effects of ergothioneine (ERG) on behavioural responses of stallions to exercise during hot-dry and rainy seasons. Eighteen healthy stallions were divided into three groups of six horses each. Group I (ERG + Exercise) was treated with ERG before exercise, group II was treated after exercise (Exercise + ERG), and group III (Exercise only) was not treated but subject to exercise. The stallions were subjected to a race of 2,000 m at maximum speed. The time spent standing by the horses in the ERG + Exercise and Exercise + ERG groups (1430.31 ± 30.73 s/30 min and 1403.32 ± 32.43 s/30 min, respectively) were higher (P < 0.0001) than the time spent standing in the Exercise-only group (1033.26 ± 21.19 s/30 min). The number of times the stallions bit their cribs per 30 min in the ERG + Exercise (0.38 ± 0.02/30 min) and Exercise + ERG (0.67 ± 0.0530 min) groups was lower (P < 0.0001) than that recorded in the Exercise-only group (3.51 ± 1.7730 min). It was concluded that ERG modulates behavioural responses to exercise in stallions, and the agent may be beneficial in alleviating exercise-induced stress responses and improving the welfare of horses post-exercise.
Determinants of Government Debt in Sub-Saharan African Countries: The Role of Conflict, Governance, and Economic Factors
Authors: Nikolaidou Eftychia , Okwoche Princewill 
Published: March 2023

Abstract
In recent years, there have been growing concerns around the implications of large fiscal imbalances in sub-Saharan African countries (SSA). An ongoing debate focuses, among other things, on the determinants of public debt in the sub-region. Much of the recent work has, however, employed descriptive methods in quantifying the extent of the debt problem and in explaining the drivers thereof. Moreover, most studies only consider macroeconomic factors. Instead of focusing only on macroeconomic factors, this study considers the influence of conflict and governance as important drivers of public debt in SSA countries given that most of them have experienced (or are still experiencing) conflict and poor governance. Focusing on a sample of 38 SSA countries over the period 1996–2019, it employs a variety of panel methods, namely, the pooled OLS, one- and two-way fixed effects, and instrumental variables fixed effects to facilitate the comparison of results. The study finds compelling evidence showing that conflict and governance are important determinants of SSA’s public debt in addition to the economic factors. Policy recommendations based on the findings are discussed.
Gift for the gods or scrapping over scrap metal? Metallographic examination of sword fragments from the Late Bronze Age hoard from Slavonski Brod, Croatia
Authors: Perez Gonzalez M. L. , Schwab R. 
Published: March 2023

Abstract
The deposition of metal in hoards appear throughout the European Bronze Age and there is on-going dispute about motivations behind the practice of hoarding metals at that period. Therefore, nine fragments of bronze swords from a late Bronze Age hoard have been investigated by metallography and X-ray fluorescence analysis (EDXRF) in order to evaluate their conditions. The objects do not show compositional deviations from contemporaneous material, but they are of poor quality showing considerable casting defects and pronounced dendritic segregation. They may never have been finished. Nonetheless, the reasons for their destruction and burial do not become evident.
CaMKIIα Promoter-Controlled Circuit Manipulations Target Both Pyramidal Cells and Inhibitory Interneurons in Cortical Networks
Authors: Veres Judit M. , Andrasi Tibor , Nagy-Pal Petra , Hajos Norbert 
Published: March 2023

AbstractA key assumption in studies of cortical functions is that excitatory principal neurons, but not inhibitory cells express calcium/calmodulin-dependent protein kinase II subunit α (CaMKIIα) resulting in a widespread use of CaMKIIα promoter-driven protein expression for principal cell manipulation and monitoring their activities. Using neuroanatomical and electrophysiological methods we demonstrate that in addition to pyramidal neurons, multiple types of cortical GABAegic cells are targeted by adeno-associated viral vectors (AAV) driven by the CaMKIIα promoter in both male and female mice. We tested the AAV5 and AAV9 serotype of viruses with either Channelrhodopsin 2 (ChR2)-mCherry or Archaerhodopsin-T-green fluorescent protein (GFP) constructs, with different dilutions. We show that in all cases, the reporter proteins can visualize a large fraction of different interneuron types, including parvalbumin (PV), somatostatin (SST), neuronal nitric oxide synthase (nNOS), neuropeptide Y (NPY), and cholecystokinin (CCK)-containing GABAergic cells, which altogether cover around 60% of the whole inhibitory cell population in cortical structures. Importantly, the expression of the excitatory opsin Channelrhodopsin 2 in the interneurons effectively drive spiking of infected GABAergic cells even if the immunodetectability of reporter proteins is ambiguous. Thus, our results challenge the use of CaMKIIα promoter-driven protein expression as a selective tool in targeting cortical glutamatergic neurons using viral vectors.
Gas7 Is a Novel Dendritic Spine Initiation Factor
Authors: Khanal Pushpa , Boskovic Zoran , Lahti Lauri , Ghimire Aruna , Minkeviciene Rimante , Opazo Patricio , Hotulainen Pirta 
Published: March 2023

AbstractBrain stores new information by modifying connections between neurons. When new information is learnt, a group of neurons gets activated and they are connected to each other via synapses. Dendritic spines are protrusions along neuronal dendrites where excitatory synapses are located. Dendritic spines are the first structures to protrude out from the dendrite to reach out to other neurons and establish a new connection. Thus, it is expected that neuronal activity enhances spine initiation. However, the molecular mechanisms linking neuronal activity to spine initiation are poorly known. Membrane binding BAR domain proteins are involved in spine initiation, but it is not known whether neuronal activity affects BAR domain proteins. Here, we used bicuculline treatment to activate excitatory neurons in organotypic hippocampal slices. With this experimental setup, we identified F-BAR domain containing growth arrest-specific protein (Gas7) as a novel spine initiation factor responding to neuron activity. Upon bicuculline addition, Gas7 clustered to create spine initiation hotspots, thus increasing the probability to form new spines in activated neurons. Gas7 clustering and localization was dependent on PI3-kinase (PI3K) activity and intact F-BAR domain. Gas7 overexpression enhanced N-WASP localization to clusters as well as it increased the clustering of actin. Arp2/3 complex was required for normal Gas7-induced actin clustering. Gas7 overexpression increased and knock-down decreased spine density in hippocampal pyramidal neurons. Taken together, we suggest that Gas7 creates platforms under the dendritic plasma membrane which facilitate spine initiation. These platforms grow on neuronal activation, increasing the probability of making new spines and new connections between active neurons. As such, we identified a novel molecular mechanism to link neuronal activity to the formation of new connections between neurons.
Perceptual Difficulty Regulates Attentional Gain Modulations in Human Visual Cortex
Authors: Sawetsuttipan Prapasiri , Phunchongharn Phond , Ounjai Kajornvut , Salazar Annalisa , Pongsuwan Sarigga , Intrachooto Singh , Serences John T. , Itthipuripat Sirawaj 
Published: March 2023

Perceptual difficulty is sometimes used to manipulate selective attention. However, these two factors are logically distinct. Selective attention is defined by priority given to specific stimuli based on their behavioral relevance, whereas perceptual difficulty is often determined by perceptual demands required to discriminate relevant stimuli. That said, both perceptual difficulty and selective attention are thought to modulate the gain of neural responses in early sensory areas. Previous studies found that selectively attending to a stimulus or increasing perceptual difficulty enhanced the gain of neurons in visual cortex. However, some other studies suggest that perceptual difficulty can have either a null or even reversed effect on gain modulations in visual cortex. According to Yerkes–Dodson's Law, it is possible that this discrepancy arises because of an interaction between perceptual difficulty and attentional gain modulations yielding a nonlinear inverted-U function. Here, we used EEG to measure modulations in the visual cortex of male and female human participants performing an attention-cueing task where we systematically manipulated perceptual difficulty across blocks of trials. The behavioral and neural data implicate a nonlinear inverted-U relationship between selective attention and perceptual difficulty: a focused-attention cue led to larger response gain in both neural and behavioral data at intermediate difficulty levels compared with when the task was more or less difficult. Moreover, difficulty-related changes in attentional gain positively correlated with those predicted by quantitative modeling of the behavioral data. These findings suggest that perceptual difficulty mediates attention-related changes in perceptual performance via selective neural modulations in human visual cortex.SIGNIFICANCE STATEMENTBoth perceptual difficulty and selective attention are thought to influence perceptual performance by modulating response gain in early sensory areas. That said, less is known about how selective attention interacts with perceptual difficulty. Here, we measured neural gain modulations in the visual cortex of human participants performing an attention-cueing task where perceptual difficulty was systematically manipulated. Consistent with Yerkes–Dodson's Law, our behavioral and neural data implicate a nonlinear inverted-U relationship between selective attention and perceptual difficulty. These results suggest that perceptual difficulty mediates attention-related changes in perceptual performance via selective neural modulations in visual cortex, extending our understanding of the attentional operation under different levels of perceptual demands.
Concurrent- and After-Effects of Medial Temporal Lobe Stimulation on Directed Information Flow to and from Prefrontal and Parietal Cortices during Memory Formation
Authors: Das Anup , Menon Vinod 
Published: March 2023

Electrical stimulation of the medial temporal lobe (MTL) has the potential to uncover causal circuit mechanisms underlying memory function. However, little is known about how MTL stimulation alters information flow with frontoparietal cortical regions implicated in episodic memory. We used intracranial EEG recordings from humans (14 participants, 10 females) to investigate how MTL stimulation alters directed information flow between MTL and PFC and between MTL and posterior parietal cortex (PPC). Participants performed a verbal episodic memory task during which they were presented with words and asked to recall them after a delay of ∼20 s; 50 Hz stimulation was applied to MTL electrodes on selected trials during memory encoding. Directed information flow was examined using phase transfer entropy. Behaviorally, we observed that MTL stimulation reduced memory recall. MTL stimulation decreased top-down PFC→MTL directed information flow during both memory encoding and subsequent memory recall, revealing aftereffects more than 20 s after end of stimulation. Stimulation suppressed top-down PFC→MTL influences to a greater extent than PPC→MTL. Finally, MTL→PFC information flow on stimulation trials was significantly lower for successful, compared with unsuccessful, memory recall; in contrast, MTL→ventral PPC information flow was higher for successful, compared with unsuccessful, memory recall. Together, these results demonstrate that the effects of MTL stimulation are behaviorally, regionally, and directionally specific, that MTL stimulation selectively impairs directional signaling with PFC, and that causal MTL-ventral PPC circuits support successful memory recall. Findings provide new insights into dynamic casual circuits underling episodic memory and their modulation by MTL stimulation.SIGNIFICANCE STATEMENTThe medial temporal lobe (MTL) and its interactions with prefrontal and parietal cortices (PFC and PPC) play a critical role in human memory. Dysfunctional MTL-PFC and MTL-PPC circuits are prominent in psychiatric and neurologic disorders, including Alzheimer's disease and schizophrenia. Brain stimulation has emerged as a potential mechanism for enhancing memory and cognitive functions, but the underlying neurophysiological mechanisms and dynamic causal circuitry underlying bottom-up and top-down signaling involving the MTL are unknown. Here, we use intracranial EEG recordings to investigate the effects of MTL stimulation on causal signaling in key episodic memory circuits linking the MTL with PFC and PPC. Our findings have implications for translational applications aimed at realizing the promise of brain stimulation-based treatment of memory disorders.