bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of macroeconomic news announcements on the implied volatility of commodities: The role of survey releases
Authors: Fernandez‐Perez Adrian , López Raquel 
Published: June 2023

AbstractWe examine the response of the implied volatility in crude oil, gold, and silver commodity markets to macroeconomic news announcements. We find that macroeconomic releases reduce uncertainty in commodity markets consistent with the hypothesis of uncertainty resolution following scheduled news announcements, while macroeconomic releases from the category of survey news announcements increase it. This result can be explained by the qualitative nature of these surveys and their ability to provide information in advance of major official macroeconomic indicators. Nevertheless, we show that survey news announcements can also be useful in resolving commodity market uncertainty in periods of heightened global financial turmoil and when the manufacturing sector of the largest economies is in contraction.
Associations between neuropsychiatric symptoms of affective and vegetative domains and brain morphology in aging people with mild cognitive impairment and Alzheimer's disease
Authors: Cannizzaro Adriana , Ronat Lucas , El Haffaf Lyna Mariam , Hanganu Alexandru ,   for the ADNI
Published: June 2023

AbstractObjectiveNeuropsychiatric symptoms (NPS) are common in mild cognitive impairment (MCI) and even more in Alzheimer's disease (AD). The symptom‐based cluster including nighttime disturbances, depression, appetite changes, anxiety, and apathy (affective and vegetative symptoms) was associated with an increased risk of dementia in MCI and has common neuroanatomical associations. Our objective was to investigate the differences in brain morphology associations with affective and vegetative symptoms between three groups: cognitively normal older adults (CN), MCI and AD.Material and MethodsAlzheimer's Disease Neuroimaging Initiative data of 223 CN, 367 MCI and 175 AD, including cortical volumes, surface areas and thicknesses and severity scores of the five NPS were analyzed. A whole‐brain vertex‐wise general linear model was performed to test for intergroup differences (CN‐MCI, CN‐AD, AD‐MCI) in brain morphology associations with five NPS. Multiple regressions were conducted to investigate cortical change as a function of NPS severity in the AD‐MCI contrast.ResultsWe found (1) signature differences in nighttime disturbances associations with prefrontal regions in AD‐MCI, (2) signature differences in NPS associations with temporal regions in AD‐MCI for depression and in CN‐AD for anxiety, (3) decreased temporal metrics in MCI as nighttime disturbances and depression severity increased, (4) decreased pars triangularis metrics in AD as nighttime disturbances and apathy severity increased.ConclusionEach NPS seems to have a signature on brain morphology. Affective and vegetative NPS were primarily associated with prefrontal and temporal regions. These signatures open the possibility of potential future assessments of links between brain morphology and NPS on an individual level.
‘Scorched Earth: The portrait of health in Brazil after the Bolsonaro's administration and the first 100 days of the Lula Government in health’
Authors: Chioro Arthur , Gomes Temporão José , Massuda Adriano , Costa Humberto , Castro Márcia , Trindade Nísia 
Published: June 2023

AbstractThis article is a rejoinder to the rebuttal letter authored by Jair Bolsonaro's former Minister of Health and Secretary of Primary Care to our initial article, ‘From Bolsonaro to Lula: The opportunity to rebuild universal healthcare in Brazil during the government transition,’ published in the International Journal of Health Planning and Management. We aim to refute the claims that we consider unsubstantiated and disconnected from reality, while reiterating the risks posed by authoritarian and antidemocratic far‐right governments, such as Bolsonarism in Brazil, to the sustainability and resilience of universal health systems. This political threat is gaining momentum across several countries worldwide, thereby endangering the Democratic Rule of Law, institutions, and social policies. Furthermore, we emphasise the significant actions implemented during the first 100 days of President Lula's government, which align with the priorities established during the governmental transition process and strengthen the prospects of reconstructing and fortifying the Brazilian universal health system.
Prevalence and risk factors of obstetric violence in the Gaza strip: A retrospective study from a conflict setting
Authors: Ismail Alaa M. , Ismail Anas , Hirst Jane Elizabeth 
Published: June 2023

AbstractObjectivesTo assess the prevalence and risk factors of obstetric violence (OV) among laboring women in the past 5 years in the Gaza Strip (GS).MethodsWomen who delivered between January 2017 and December 2021 were invited to complete an anonymous online survey between November 2021 and February 2022 to explore their experiences of labor.ResultsSeven hundred twenty‐two women completed the online questionnaire. Two‐thirds (484; 67.2%) were in their 20s, and half (362; 50.1%) were from low socioeconomic households. A vast majority (508; 70.4%) delivered in a government hospital. Four out of ten (300; 41.6%) reported experiencing at least one form of OV. Among these women, the types of OV reported were physical (143; 47.8%), psychological (122; 40.8%), verbal (109; 36.4%), and sexual (13; 4.4%). Delivery in private facilities (adjusted odds ratio [AOR] 0.45, 95% confidence interval [CI] 0.32–0.74) and prior knowledge of the care provider (AOR 0.37, 95% CI 0.23–0.59) were both independently protective for OV. In contrast, women's awareness of OV increased their likelihood of reporting it (AOR 3.45, 95% CI 2.37–5.01).ConclusionGS has an alarming prevalence of reported OV. Increasing awareness of OV, identifying its causes, and developing locally led initiatives to eliminate it are urgently needed.
Endogenous endophthalmitis secondary to perirenal abscess
Authors: Lizana Nemecio , Parrao Diego , Larrañaga Matías , Figueroa‐Vercellino Juan P , Pozo Karen , Bravo Juan Cristóbal 
Published: June 2023

IntroductionEndogenous Endophthalmitis is a rare ocular infection but with poor visual prognosis for most patients. Its most frequent etiology is Klebsiella spp., associated with hepatic abscesses and less frequently with perirenal abscesses.Case presentationWe present a 61‐year‐old woman with a history of poorly controlled diabetes mellitus 2 that consulted several times for acute pyelonephritis with torpid evolution, associated with endogenous endophthalmitis in her right eye that required evisceration.ConclusionAdequate management of acute pyelonephritis can avoid local or distant complications, such as endogenous endophthalmitis, an infection with poor visual prognosis that requires high clinical suspicion for timely management with better visual outcomes and lower morbimortality.
Ultimate fate, transformation, and toxicological consequences of herbicide pretilachlor to biotic components and associated environment: An overview
Authors: Dhanda Vidhi , Kumar Ravi , Yadav Neelam , Sangwan Sarita , Duhan Anil 
Published: June 2023

AbstractHerbicides are applied for effective weed management in order to increase the crop yield. In recent decades, the overuse of these chemicals has posed adverse effects on different biotic components of the environment. Pretilachlor has been widely used during last few decades for weed management in paddy crop. Its excessive use may prove fatal for environment, various organisms, and nontarget plants. Thus, it is pertinent to know the extent to which herbicide residues remain in environment. The potential mobility and the release rate of herbicide in the soil are important factors governing ecotoxicological impact and degradation rate. Therefore, several techniques are being investigated for its effective removal from the contaminated sites. Furthermore, efforts have also been made to study the degradation of pretilachlor by various physicochemical processes, resulting into the formation of different types of metabolites. This review summarizes the available information on environmental fate, various degradation processes, microbial biotransformation, metabolites formed, ecotoxicological effects, techniques for detection in environmental samples, effect of safener, and various control release formulations for sustained release of pretilachlor in applied fields. The information so obtained will be very advantageous in deciding the future policies for safe and judicious use of the herbicide by maintaining health and environmental sustainability.
Dynamics of Skeletal Status under Optimized Management during Subsequent Pregnancy in Three Women with a History of Pregnancy‐ and Lactation‐Associated Osteoporosis Carrying pathogenic Variants in WNT1 and LRP5
Authors: Stürznickel Julian , Butscheidt Sebastian , Amling Michael , Oheim Ralf 
Published: June 2023

AbstractPregnancy‐ and lactation‐associated osteoporosis (PLO) is a rare but clinically highly relevant condition, characterized by reduced bone mineral density (BMD) and acute onset of severe pain due to symptomatic bone marrow edema of the hip or vertebral and/or insufficiency fractures, among others. Previous reports showed a high frequency of hereditary bone disorders unmasked by PLO, predisposing for more severe forms. To date, no data on the risk for additional fractures during subsequent pregnancy in women with PLO and genetic bone disorder have been available. To address this question, we retrospectively analyzed the clinical, biochemical, and densitometric course of three women with a history of PLO and detected variants in WNT1 or LRP5 and subsequent pregnancies. Calcium homeostasis and bone turnover were optimized by basic treatment, and timely initiation of weaning was recommended. Teriparatide treatment for 12 months under strict contraception was initiated in one woman after the diagnosis of PLO. In none of the women did additional fractures or symptomatic bone marrow edemas occur, and BMD by dual‐energy X‐ray absorptiometry as bone microarchitecture by high‐resolution peripheral quantitative computed tomography remained stable. In conclusion, this report expands the understanding of this rare but severe condition and helps to improve clinical counseling and management. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Melatonin attenuates monocrotaline‐induced hepatic sinusoidal obstruction syndrome in rats via activation of Sirtuin‐3
Authors: Ren Xiaofei , Xu Kui , Xu Jianming , Mei Qiao 
Published: June 2023

AbstractMelatonin possesses potent hepatoprotective properties, but it remains to be elucidated whether melatonin has a therapeutic effect on monocrotaline (MCT)‐induced hepatic sinusoidal obstruction syndrome (HSOS). In this study, male Sprague Dawley rats were intraperitoneally injected with melatonin or the same volume of vehicle at 0 and 24 h after MCT intragastric administration. Next, hematoxylin–eosin staining and electron microscopy were performed to evaluate the hepatic sinusoidal injury of rats. Endothelial cell marker RECA‐1 was observed by immunohistochemistry. Hepatic oxidative stress was analyzed by detecting malondialdehyde, glutathione S‐transferase, and reactive oxygen species. Assessment of liver function was carried out by analysis of serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, and albumin levels. Real‐time polymerase chain reaction and Western blot analysis were used to identify liver Sirtuin‐3 (SIRT3) and active matrix metallopeptidase 9 (MMP‐9) expression. Besides, liver sinusoidal endothelial cells (LSECs) were used for the in vitro functional verification experiment. Specifically, liver histology of the melatonin‐treated groups showed that the pathological damages caused by MCT were significantly attenuated, total HSOS scores were decreased, and the elevation of serum hyaluronic acid observed in the model group was also reduced. Moreover, melatonin treatment also improved the survival of rats after partial hepatectomy. Administration of melatonin ameliorated MCT‐induced LSECs injury, hepatic oxidative stress, and hepatic dysfunction. Furthermore, melatonin treatment increased SIRT3 expression while attenuating MMP‐9 activity in liver tissues. Cell experiment also demonstrated that SIRT3 might mediate the protective effect of melatonin on LSECs. Collectively, our study provided the potential rationale for the application of melatonin for the prevention of MCT‐induced HSOS.
C‐type natriuretic peptide (CNP) inhibits 7,12‐Dimethylbenz[a]anthracene (DMBA)/Croton oil‐induced skin tumor growth by modulating inflammation in Swiss albino mice
Authors: Dhanusu Sivakalai Suresh , Sowndhar Rajan Boopathi , Vellaichamy Elangovan 
Published: June 2023

AbstractC‐type natriuretic peptide (CNP) exhibits anti‐inflammatory activity besides its natriuretic and diuretic functions. The present study aimed to determine the anticancer and synergistic therapeutic activity of CNP against a 7,12‐Dimethylbenz[a]anthracene (DMBA)/Croton oil‐induced skin tumor mouse model. CNP (2.5 µg/kg body weight) was injected either alone and/or in combination with Cisplatin (CDDP) (2 mg/kg body weight) for 4 weeks. The dorsal skin tumor incidences/growth and mortality rate were recorded during the experimental period of 16 weeks. The serum C‐reactive protein (CRP), and lactate dehydrogenase (LDH) levels, infiltrating mast cells, and AgNORs proliferating cells count were analyzed in control and experimental mice. Further, the expression profile of marker genes of proliferation, inflammation, and progression molecules were analyzed using Reverse transcriptase‐polymerase chain reaction (RT‐PCR)/quantitative PCR (qPCR), western blot, and immunohistochemistry. The DMBA/Croton oil‐induced mice exhibited 100% tumor incidence. Whereas, CNP alone, CDDP alone, and CNP+CDDP combination‐treated mice exhibited 58%, 46%, and 24% tumor incidence, respectively. Also, a marked reduction in the levels of serum CRP and LDH, the number of infiltrating mast cells count and AgNORs proliferating cells count were noticed in the mice skin sections. Further, a significant reduction in both mRNA and protein expression levels of proliferation, inflammation, and progression markers were noticed in CNP (p < 0.01), CDDP (p < 0.01), and CNP+CDDP combination (p < 0.001) treated mice, respectively. The results of the present study suggest that CNP has anticancer activity. Further, the CNP+CDDP treatment has more promising anticancer activity as compared with CNP or CDDP alone treatment, probably due to the synergistic antiproliferative and anti‐inflammatory activities of CNP and CDDP.
Upregulation of lncRNA PTOV1‐AS1 in hepatocellular carcinoma contributes to disease progression and sorafenib resistance through regulating miR‐505
Authors: Chi Xiaobin , Chen Zhijian , Chen Yongbiao , Hong Hanyin , Yu Jianda , Lv Lizhi 
Published: June 2023

AbstractIncreasing evidence has displayed the vital influence of lncRNA in tumorigenesis and chemoresistance of cancer treatment. This study investigated the function of lncRNA PTOV1‐AS1 in hepatocellular carcinoma (HCC) and its role in sorafenib resistance. The relative expression of lncRNA and miRNA was measured by RT‐qPCR. The cellular activities including cell proliferation and invasion were explored by CCK‐8 and Transwell assays. Bioinformatics analysis and dual‐luciferase reporter assay were used to predict the targeting miRNA of PTOV1‐AS1. The expression levels of PTOV1‐AS1 were higher in HCC tissues than that in the normal tissues and associated with patients' overall survival. Knockdown of PTOV1‐AS1 decreased cell proliferation rate and invasion number. After treatment with different concentrations of sorafenib, the sorafenib‐resistant hepatoma cells were conducted. PTOV1‐AS1 expression levels were increased in HepG2‐SR and Huh7‐SR cells. PTOV1‐AS1 knockdown repressed the proliferation, invasion, and drug resistance of sorafenib‐resistant HCC cells by targeting the expression of miR‐505. In conclusion, the expression of PTOV1‐AS1 is increased in HCC and sorafenib‐resistance HCC cells, as well as is associated with patients' prognosis. Inhibition of PTOV1‐AS1 expression can reduce the resistance of sorafenib‐resistant HCC cells, which may play a role by targeting the negative regulation of miR‐505 expression.
Oxidative brain and cerebellum injury in diabetes and prostate cancer model: Protective effect of metformin
Authors: Dagsuyu Eda , Koroglu Pınar , Gul Ilknur B. , Bulan Omur K. , Yanardag Refiye 
Published: June 2023

AbstractThe body can host the spread of prostate cancer cells. Metastases from prostate cancer are more frequently seen in the brain, liver, lungs, and lymph nodes. A well‐known antidiabetic drug, metformin, is also known to have antitumor effects. Our study focuses on the evaluation of potential metformin protective effects on brain and cerebellum damage in streptozotocin (STZ)‐induced diabetic and Dunning prostate cancer models. In this investigation, six groups of male Copenhagen rats were created: control, diabetic (D), cancer (C), diabetic + cancer (DC), cancer + metformin, and diabetic + cancer + metformin. The brain and cerebellum tissues of the rats were taken after sacrifice. Oxidative stress markers including reduced glutathione level, lipid peroxidation, glutathione reductase, glutathione peroxidase, glutathione‐S‐transferase, catalase, superoxide dismutase activities, reactive oxygen species, total oxidant and total antioxidant status, lactate dehydrogenase, xanthine oxidase, acetylcholinesterase activities, protein carbonyl contents, nitric oxide and OH‐proline levels, sodium potassium ATPase, carbonic anhydrase, and glucose‐6‐phosphate dehydrogenase activities; glycoprotein levels including hexose, hexosamine, fucose, and sialic acid levels; and histone deacetylase activity as a cancer marker were determined. Oxidative stress markers were impaired and glycoprotein levels and histone deacetylase activity were increased in the D, C, and DC groups. Metformin therapy reversed these effects. Metformin was found to protect the brain and cerebellum of STZ‐induced diabetic rats with Dunning prostate cancer from harm caused by MAT‐Lylu metastatic cells.
Cbl induced ubiquitination of HER2 mediate immune escape from HER2‐targeted CAR‐T
Authors: Yang Yanqiu , Sun Qingqing , Deng Zhiping , Shi Wencong , Cheng Hao 
Published: June 2023

AbstractBreast cancer (BC) with high HER2 expression has higher recurrence rate and worse prognosis, and its immunotherapy is promising. Based on the high expression of HER2, develop Chimeric Antigen Receptor T‐cell (CAR‐T) and PDL‐1 immunotherapy, and study the molecular pathways of related immune cells and recurrence. HER2‐CAR‐T cells were constructed using retroviruses, and their specific recognition and immune effects on HER2+ BC cells were verified by in vivo and in vitro experiments. PDL‐1 was used as adjuvant immunotherapy, knocking down PDL‐1 in tumor cells or dendritic cells, or depleted macrophages to study immune pathways. The negative regulation of HER2 by cbl was determined by IP, ubiquitination experiments, and segmented plasmids, elucidating the molecular mechanism of HER2+ BC recurrence after immunotherapy. HER2‐CAR‐T specifically recognizes HER2‐positive tumor cells and inhibits tumor growth in vivo and in vitro, and anti‐PDL1 treatment enhances the therapeutic effect of HER2‐CAR‐T on tumors. HER2‐CART therapy eradicated solid tumors after PDL1 knockdown in dendritic cells. Immunotherapy of relapsed tumors lost HER2 expression by upregulating cbl. HER2‐CAR‐T shows specific recognition of HER2+ cells and can mediate immune response therapy with the cooperation of PDL‐1.
Distinct responses of soil bacterial communities to N and P fertilization in a Tibetan alpine meadow of China
Authors: Zi Hongbiao , Hu Yigang , Hu Lei , Wang Changting 
Published: June 2023

AbstractIncreased nitrogen (N) and phosphorus (P) availability, due to fertilization and deposition, is expected to influence soil microbial community structure and function. However, little is known about the sensitivity and dependency of soil microbial structure on the levels of N and P, and on the integration of N and P inputs in alpine meadow ecosystems. Here, we implemented a 3‐year manipulative fertilization study with four levels (0, 10, 20, and 30 g m−2) of N fertilization, P fertilization, and NP fertilization (N and P fertilization at a ratio of 1:1) in a Tibetan alpine meadow. We examined how greater N and P availability affected bacterial community diversity, community structure in the top‐ (0–10 cm) and sub‐top (10–20 cm) soil, network topological properties, and the potential mechanisms behind them. Although the α and β diversities of bacteria within top‐ and sub‐topsoil were not significantly different from those in the control across N, P, and NP fertilization levels, the integration of NP fertilization significantly changed the relative abundances of more bacterial phyla than the N and P fertilization did separately. Furthermore, the N10 and N20 fertilization treatments strengthened bacterial interactions, whereas P and NP fertilization did not affect the complexity and connectivity of the soil bacterial co‐occurrence network. In addition, the mechanism of structuring the bacterial community for separate N and P fertilization differed from that for NP fertilization. The separate application of N and P fertilization affected the bacterial community composition mainly through changes in the total and available P levels in the soil, respectively, whereas NP fertilization shifted the bacterial community composition through decreasing plant species richness. These findings provide a quantification of the response of soil bacterial diversity and composition to different levels of N, P, and NP fertilization. It also suggests that in the Tibetan alpine meadow, soil bacterial communities may alter their fitness according to the relative abundances of oligotrophic/copiotrophic bacterial taxa, rather than through changing their diversity.
Invertebrate communities (Collembola and Acari) in soil cover treatments for mine tailings in a long‐term field experiment
Authors: Pelaez‐Sanchez Sara , Schmidt Olaf , Proto Mariagrazia , Courtney Ronan 
Published: June 2023

AbstractAssessment of mine rehabilitation strategies including soil cover treatments rely mainly on soil physico‐chemical properties or plant performance indices, while much less is known about the response of biological soil properties. This field study evaluated the response of soil mesofauna (Collembola and Acari) in soil cover treatments (mainly subsoil and subsoil) on mine tailings, with or without organic amendments. The field experiment was conducted in large (1 m3) units rehabilitated in 2014, and mesofauna in soil cores was assessed 7 years later. The richness of Collembola and Acari as well as the density of Acari increased with organic amendments. Collembola community composition changed with the addition of soil cover and organic amendments. The density and community composition of Acari were strongly positively associated with organic carbon. The density of Euedaphic Collembola decreased, whereas Hemiedaphic and Epedaphic forms increased with soil cover. The contribution of generalist and metal‐tolerant species explained the high density of Euedaphic life forms in tailings. Species‐specific traits for Collembola and Acari could play an essential role in explaining the response of populations to treatments, such as affinity for C‐enriched habitats, food preferences, and sensitivity to heavy metals. Overall, it is recommended to use a multiple diversity indices approach, to collect data on the density and assemblage of mesofauna species to investigate the response of mesofauna communities to soil cover treatments. Mine tailings rehabilitation strategies should focus on improving the nutrient content of soil covers, since it benefits diversity and density of soil fauna.