bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of health-state utilities used in cost-effectiveness analyses: a systematic review of published studies in Asia
Authors: Yang Zhihao , Zeng Xueyun , Huang Weidong , Chai Qingqing , Zhao Angela , Chuang Ling-Hsiang , Wu Bin , Luo Nan 
Published: June 2023

Abstract
Introduction
Cost-utility analysis (CUA) is the preferred form of economic evaluation in many countries. As one of the key data inputs in cost-utility models, health state utility (HSU) has a crucial impact on CUA results. In the past decades, health technology assessment has been expanding rapidly in Asia, yet research examining the methodology and process used to generate cost-effectiveness evidence is scarce. The aim of this study was to examine the reporting of the characteristics of HSU data used in CUAs in Asia and how the characteristics have changed over time.

Methods
A systematic literature search was performed to identify published CUA studies targeting Asian populations. Information was extracted for both the general characteristics of selected studies and the characteristics of reported HSU data. For each HSU value identified, we extracted data for four key characteristics, including 1) estimation method; 2) source of health-related quality of life (HRQoL) data; 3) source of preference data; and 4) sample size. The percentage of nonreporting was calculated and compared over two time periods (1990–2010 vs 2011–2020).

Results
A total of 789 studies were included and 4,052 HSUs were identified. Of these HSUs, 3,351 (82.7%) were from published literature and 656 (16.2%) were from unpublished empirical data. Overall, the characteristics of HSU data were not reported in more than 80% of the studies. Of HSUs whose characteristics were reported, most of them were estimated using the EQ-5D (55.7%), Asian HRQoL data (91.9%), and Asian health preferences (87.7%); 45.7% of the HSUs was estimated with a sample of 100 or more individuals. All four characteristics showed improvements after 2010.

Conclusion
Over the past two decades, there has been a significant increase in CUA studies targeting Asian populations. However, HSU’s characteristics were not reported in most of the CUA studies, making it difficult to evaluate the quality and appropriateness of the HSUs used in those cost-effectiveness studies.
Factors that influence the adoption of rehabilitation technologies: a multi-disciplinary qualitative exploration
Authors: Mitchell Jessie , Shirota Camila , Clanchy Kelly 
Published: June 2023

Abstract
Background
Technological innovation is recognised as having the potential to enhance rehabilitation for people with disability. Yet, resistance to, and abandonment of, rehabilitation technology is prevalent and the successful translation of technology into rehabilitation settings remains limited. Therefore, the aim of this work was to develop an in-depth, multi-stakeholder perspective on what influences the adoption of rehabilitation technologies.

Methods
Semi-structured focus groups were conducted as part of a larger research project aiming to facilitate the co-design of a novel neurorestorative technology. Focus group data were analysed using a five-phase hybrid deductive-inductive approach to qualitative data analysis.

Results
Focus groups were attended by 43 stakeholders with expertise in one or more of the following fields: people with disability, allied health, human movement science, computer science, design, engineering, ethics, funding, marketing, business, product development, and research development. Six main themes influencing the adoption of technology in rehabilitation were identified: cost beyond the purchase price, benefits to all stakeholders, trust to be earned in technology, ease of technology operation, ability to access technology, and the ‘co’ in co-design. All six themes were found to be interrelated; in particular, the importance of direct stakeholder engagement in the development of rehabilitation technologies (the ‘co’ in co-design) was prevalent in all themes.

Conclusions
A range of complex and interrelated factors influence the adoption of rehabilitation technologies. Importantly, many of the issues that have the potential to negatively impact rehabilitation technology adoption may be addressed during development by utilising the experience and expertise of stakeholders who influence its supply and demand. Our findings state that a wider cohort of stakeholders needs to be actively engaged in the development of rehabilitation technologies to better address the factors that contribute to technology underutilisation and abandonment and facilitate better outcomes for people with disability.
Outcome and complication comparison for intramedullary nail versus open reduction internal fixation in humeral diaphyseal fractures for 2800 matched patient pairs utilizing the Nationwide Readmissions Database
Authors: Oldenburg Kirsi S. , Welsh Megan E. , Goodloe Jonathan Brett , Friedman Richard J. , Eichinger Josef K. 
Published: June 2023

Abstract
Introduction
Open reduction internal fixation (ORIF) and intramedullary nail fixation (IMN) are the predominant repair methods for operative treatment of humeral diaphyseal fractures; however, the optimal method is not fully elucidated. The purpose of this study was to analyze whether IMN or ORIF humeral diaphyseal surgeries result in a significantly higher prevalence of adverse outcomes and whether these outcomes were age dependent. We hypothesize there is no difference in reoperation rates and complications between IMN and ORIF for humeral diaphyseal fractures.

Methods
Data collected from 2015 to 2017 from the Nationwide Readmissions Database were evaluated to compare the prevalence of six adverse outcomes: radial nerve palsy, infections, nonunion, malunion, delayed healing, and revisions. Patients treated for a primary humeral diaphyseal fracture with either IMN or ORIF were matched and compared (n = 2,804 pairs). Patients with metastatic cancer were excluded.

Results
Following an ORIF procedure, there was a greater odds of undergoing revision surgery (p = 0.03) or developing at least one of the complications of interest (p = 0.03). In the age-stratified analysis, no significant differences were identified in the prevalence of adverse outcomes between the IMN and ORIF cohorts in the 0–19, 20–39, and 40–59 age groups. Patients who were 60 + had 1.89 times the odds of experiencing at least one complication and 2.04 times the odds of undergoing a revision after an ORIF procedure versus an IMN procedure (p = 0.03 for both).

Discussion
IMN and ORIF for humeral diaphyseal fractures are comparable in regard to complications revision rates in patients under the age of 60. Meanwhile, patients 60 + years show a statistically significant increase in the odds of undergoing revision surgery or experiencing complications following an ORIF. Since IMN appears to be more beneficial to older patients, being 60 + years old should be considered when determining fracture repair techniques for patients presenting with primary humeral diaphyseal fractures.
Level of Evidence III.
A streptavidin–biotin system combined with magnetic actuators for remote neuronal guidance
Authors: Levenberg Dafna Rivka , Varon Eli , Indech Ganit , Ben Uliel Tal , Geri Lidor , Sharoni Amos , Shefi Orit 
Published: June 2023

AbstractThe ability to control neuronal mobility and organization is of great importance in developing neuronal interfaces and novel therapeutic approaches. An emerging promising method is the manipulation of neuronal cells from afar via magnetic forces. Nevertheless, using magnetic iron oxide nanoparticles as internal actuators may lead to biotoxicity, adverse influence on intracellular processes, and thus requires prerequisite considerations for therapeutic approaches. Magnetizing the cells via the incorporation of magnetic particles that can be applied extracellularly is advantageous. Herein, we have developed a magnetic system based on streptavidin–biotin interaction to decorate cellular membrane with magnetic elements. In this model, superparamagnetic microparticles, coated with streptavidin, were specifically bound to biotinylated PC12 cells. We demonstrated that cell movement can be directed remotely by the forces produced by pre-designed magnetic fields. First, using time lapse imaging, we analyzed the kinetics of cell migration towards the higher flux zone. Next, to form organized networks of cells we designed and fabricated micro-patterned magnetic devices. The fabricated devices were composed of a variety of ferromagnetic shapes, sputter-deposited onto glass substrates. Cells that were conjugated to the magnetic particles were plated atop the micro-patterned substrates, attracted to the magnetic actuators and became fixed onto the magnetic patterns. In all, our study presents a novel system based on a well-known molecular technology combined with nanotechnology that may well lead to the expansion of implantable magnetic actuators to organize and direct cellular growth.
Genome wide identification and characterization of fertility associated novel CircRNAs as ceRNA reveal their regulatory roles in sheep fecundity
Authors: Yousuf Salsabeel , Malik Waqar Afzal , Feng Hui , Liu Tianyi , Xie Lingli , Miao Xiangyang 
Published: June 2023

AbstractReproductive traits play a vital role in determining the production efficiency of sheep. Maximizing the production is of paramount importance for breeders worldwide due to the growing population. Circular RNAs (circRNAs) act as miRNA sponges by absorbing miRNA activity through miRNA response elements (MREs) and participate in ceRNA regulatory networks (ceRNETs) to regulate mRNA expression. Despite of extensive research on role of circRNAs as miRNA sponges in various species, their specific regulatory roles and mechanism in sheep ovarian tissue are still not well understood. In this study, we performed whole genome sequencing of circRNAs, miRNA and mRNA employing bioinformatic techniques on ovine tissues of two contrasting sheep breeds "Small tail Han (X_LC) and Dolang sheep (D_LC)", which results into identification of 9,878 circRNAs with a total length of 23,522,667 nt and an average length of 2,381.32 nt. Among them, 44 differentially expressed circRNAs (DECs) were identified. Moreover, correlation between miRNA-mRNA and lncRNA-miRNA provided us with to prediction of miRNA binding sites on nine differentially expressed circRNAs and 165 differentially expressed mRNAs using miRanda. miRNA-mRNA and lncRNA-miRNA pairs with negative correlation were selected to determine the ceRNA score along with positively correlated pairs from lncRNA and mRNA network. Integration of ceRNA score and positively correlated pairs exhibit a significant ternary relationship among circRNAs-miRNA-mRNA demonestrated by ceRNA, comprising of 50 regulatory pairs sharring common nodes and predicted potential differentially expressed circRNAs-miRNAs-mRNAs regulatory axis. Based on functional enrichment analysis shortlisted key ceRNA regulatory pairs associated with reproduction including circRNA_3257-novel579_mature-EPHA3, circRNA_8396-novel130_mature-LOC101102473, circRNA_4140- novel34_mature > novel661_mature-KCNK9, and circRNA_8312-novel339_mature-LOC101110545. Furthermore, expression profiling, functional enrichments and qRT-PCR analysis of key target genes infer their implication in reproduction and metabolism. ceRNA target mRNAs evolutionary trajectories, expression profiling, functional enrichments, subcellular localizations following genomic organizations will provide new insights underlying molecular mechanisms of reproduction, and establish a solid foundation for future research.
Graphical Abstract
Graphical abstract summarizing the scheme of study
Testing of a new Yb:YAG fiber laser system for the removal of graphic vandalism from marble
Authors: Suzuki Amelia , Riminesi Cristiano , Ricci Marilena , Vettori Silvia , Salvadori Barbara 
Published: June 2023

Abstract
Graphic vandalism causes detrimental effects on architectural stone surfaces. Among the cleaning methods developed in the last decades, laser cleaning showed considerable effectiveness but the available equipment still lacks full adaptability for the use on site, while the cleaning process is time-consuming for the site work requirements. In this paper, the feasibility of a fiber laser operating at 1064 nm (Yb:YAG) at high repetition rate (kHz) for the removal of vandal graffiti from marble is investigated, as it is potentially suitable for cleaning of large surfaces. Indeed, this device exploits a scan system covering a wider area than that of solid state lasers, while maintaining excellent portability. Evaluation of the cleaning procedure on a selection of spray paints and felt-tip permanent markers applied on marble mock-ups is carried out with a multimodal approach (optical microscopy combined with surface pattern reconstruction, colour monitoring, Fourier Transform Infrared spectroscopy in external reflection and ATR mode, Thin Layer Chromatography, Raman spectroscopy, thermal monitoring, scanning electron microscopy). Ablation and thermal effects are observed varying the laser setting and the type of paint layer, with repetition rate showing a strong impact on the type of interaction. Overall, best cleaning procedures are achieved for the thinning of the black marker and the removal of the black spray paint. Some residues on the best results were observed, suggesting that the laser needs to be integrated with a second step of chemical cleaning. This study, focused on graffiti removal, shows that fiber laser can be a useful tool for cleaning of large monumental surfaces.

Graphical Abstract
Latency arbitrage and the synchronized placement of orders
Authors: Kuhle Wolfgang 
Published: June 2023

AbstractWe argue that owing to traders’ inability to fully express their preferences over the execution times of their orders, contemporary stock market designs are prone to latency arbitrage. In turn, we propose a new order type, which allows traders to specify the time at which their orders are executed after reaching the exchange. Using recent latency data, we demonstrate that the order type proposed here allows traders to synchronize order executions across different exchanges, such that high-frequency traders, even if they operate at the speed of light, can no-longer engage in latency arbitrage.
Effectiveness of a cardiovascular health EHR application for cancer survivors in community oncology practice: Results from WF-1804CD.
Authors: Weaver Kathryn E. , Dressler Emily Van Meter , Klepin Heidi D. , Lee Simon Craddock , Smith Sydney , Wells Brian J , Hundley W. Gregory , Lesser Glenn Jay , Nightingale Chandylen L , Throckmorton Alyssa , Hernandez Marcia , Hanna Jenny Marie , Lackey Ian T. , Heard Kevin , Foraker Randi E ,   AH-HA study team
Published: June 2023

LBA12007 Background: Practice guidelines recommend cardiovascular risk assessment and counseling for cancer survivors. The Automated Heart-Health Assessment study (AH-HA: WF-1804CD, NCT# 03935282) evaluated a novel electronic health record (EHR) clinical decision support tool based on American Heart Association Simple 7 cardiovascular health (CVH) factors to promote provider-patient CVH discussions in outpatient oncology. Methods: This clinic-randomized trial (R01CA226078), coordinated by the Wake Forest NCORP Research Base (UG1CA189824), randomized NCORP oncology practices using the Epic EHR to the AH-HA tool or usual care and enrolled survivors receiving routine care at least 6 months post-curative cancer treatment. The tool rendered an interactive display of risk factors, automatically populated from the EHR, alongside a tab indicating receipt of cancer treatments with cardiotoxic potential. Survivors at AH-HA sites had tool access during a routine visit; survivors at usual care sites did not. Immediately post-visit, each survivor was asked about counseling on 7 CVH factors [body mass index, physical activity, diet, smoking status, blood pressure, cholesterol, and glucose]. The primary endpoint is survivor-reported discussion of non-ideal or missing CVH factors; with 8 randomized practices (ICC=0.03), the study design had 82% power to detect a difference of 20% reported discussions in usual care versus 40% in AH-HA. Additional clinical endpoints were documentation of CVH discussions, referrals to primary care and cardiology, and change in CVH factors over 12 months (ongoing). A mixed effects logistic regression model assessed the effect of AH-HA on CVH discussions between the arms, with study arm as a fixed effect and practice as a random effect. Results: 5 usual care and 4 AH-HA practices enrolled 645 survivors from 10/1/2020- 2/28/2023. The majority had breast cancer (82%; 8% endometrial, 5% colorectal, 5% prostate, lymphoma or multiple types). Most survivors were female (96%; 84% White/non-Hispanic, 8% Black; 3% Hispanic; mean age= 62 yrs and median time since diagnosis=3.6 yrs). 18 participants (3%) did not complete necessary assessments, leaving 627 evaluable. 87% of providers (n=15) rated the tool utility and ease of use positively. Conclusions: The AH-HA tool was acceptable and effective at promoting CVH discussions during routine follow-up care for survivors and referrals to primary care. Clinical trial information: NCT03935282 . [Table: see text]
Frequency, Characteristics, and Risk Factors for Falls at an Inpatient Cancer Rehabilitation Unit
Authors: Gupta Ekta , Tennison Jegy M. , Shin Ki Y. , Fu Jack B. , Rozman de Moraes Aline , Naqvi Syed Mujtaba Ali , Fellman Bryan , Bruera Eduardo 
Published: June 2023

PURPOSE Falls in the hospital can lead to adverse events, including injuries. Studies have shown that patients with cancer and those undergoing inpatient rehabilitation (IPR) are at higher risk for falls. Therefore, we measured the frequency, degree of harm, and characteristics of patients who fell in an inpatient cancer rehabilitation unit. METHODS A retrospective review was conducted on inpatient cancer rehabilitation patients admitted from January 2012 to February 2016. Fall frequency, degree of harm, fall circumstances, cancer type, patient's fall risk score on the basis of the MD Anderson Cancer Center Adult Inpatient Fall Risk Assessment Tool (MAIFRAT), length of stay, and risk factors were evaluated for patients. RESULTS There were 72 out of 1,571 unique individual falls (4.6%), with a falls incidence of 3.76 falls per 1,000 patient-days. Most fallers (86%) suffered no harm. Risk factors for falls included presence of patient-controlled analgesia pump ( P = .03), pump such as insulin or wound vacuum-assisted closure ( P < .01), nasogastric, gastric, or chest tube ( P = .05), and higher MAIFRAT score ( P < .01). The fallers were younger (62 v 66; P = .04), had a longer IPR stay (13 v 9; P = .03), and had a lower Charlson comorbidity index (6 v 8; P < .01). CONCLUSION The frequency and degree of harm for falls in the IPR unit were less than previous studies, which suggests that mobilization for these patients with cancer is safe. The presence of certain medical devices may contribute to fall risk, and more research is needed to better prevent falls in this higher-risk subgroup.
Prevalence of Deleterious Variants in MC3R in Patients With Constitutional Delay of Growth and Puberty
Authors: Duckett Katie , Williamson Alice , Kincaid John W R , Rainbow Kara , Corbin Laura J , Martin Hilary C , Eberhardt Ruth Y , Huang Qin Qin , Hurles Matthew E , He Wen , Brauner Raja , Delaney Angela , Dunkel Leo , Grinspon Romina P , Hall Janet E , Hirschhorn Joel N , Howard Sasha R , Latronico Ana C , Jorge Alexander A L , McElreavey Ken , Mericq Verónica , Merino Paulina M , Palmert Mark R , Plummer Lacey , Rey Rodolfo A , Rezende Raíssa C , Seminara Stephanie B , Salnikov Kathryn , Banerjee Indraneel , Lam Brian Y H , Perry John R B , Timpson Nicholas J , Clayton Peter , Chan Yee-Ming , Ong Ken K , O’Rahilly Stephen 
Published: June 2023

Abstract

Context
The melanocortin 3 receptor (MC3R) has recently emerged as a critical regulator of pubertal timing, linear growth, and the acquisition of lean mass in humans and mice. In population-based studies, heterozygous carriers of deleterious variants in MC3R report a later onset of puberty than noncarriers. However, the frequency of such variants in patients who present with clinical disorders of pubertal development is currently unknown.

Objective
This work aimed to determine whether deleterious MC3R variants are more frequently found in patients clinically presenting with constitutional delay of growth and puberty (CDGP) or normosmic idiopathic hypogonadotropic hypogonadism (nIHH).

Methods
We examined the sequence of MC3R in 362 adolescents with a clinical diagnosis of CDGP and 657 patients with nIHH, experimentally characterized the signaling properties of all nonsynonymous variants found and compared their frequency to that in 5774 controls from a population-based cohort. Additionally, we established the relative frequency of predicted deleterious variants in individuals with self-reported delayed vs normally timed menarche/voice-breaking in the UK Biobank cohort.

Results
MC3R loss-of-function variants were infrequent but overrepresented in patients with CDGP (8/362 [2.2%]; OR = 4.17; P = .001). There was no strong evidence of overrepresentation in patients with nIHH (4/657 [0.6%]; OR = 1.15; P = .779). In 246 328 women from the UK Biobank, predicted deleterious variants were more frequently found in those self-reporting delayed (aged ≥16 years) vs normal age at menarche (OR = 1.66; P = 3.90E-07).

Conclusion
We have found evidence that functionally damaging variants in MC3R are overrepresented in individuals with CDGP but are not a common cause of this phenotype.
Price Analysis in the European Food Supply Chain
Authors: Pachis Dimitris , Peppas George , Dimitras Augustin 
Published: June 2023

The paper assesses the degree of price cooperation between the main agricultural supply chain stakeholders in EU-27. The price transmission mechanism between producers and retailers is used for assessing cooperation. Cereals prices of EU-27 are used for the empirical analysis (January 1995 - April 2022). The price mechanism is modeled via the Co-Integrated Vector AutoRegressive (VAR) representation. The empirical analysis follows the usual drill of stationarity and co-integration tests followed by Granger Causality tests, Impulse Responses and Forecasts of Error Decomposition. The results show restricted cooperation between supply chain stakeholders.

JEL Classifications: Q13, Q18

Keywords: Price analysis, European Union - 27, supply chain management
Do econometric advances lead to more accurate VaR estimations when the legislation requirements are applied? The case of Turkish Lira FX Market.
Authors: Vasileiou Evangelos , Rizopoulos Ioannis 
Published: June 2023

This paper empirically tests the benefits of econometric advances in the field of Value at Risk (VaR) within the existing legal framework that regulates the Banking (Basel III) and Asset Management industry (CESR (2010)). We test several VaR models, from the simplest and the most easily applied, i.e. the Historical VaR (HVaR), Variance Covariance VaR (VCVaR), and the Exponential Weighted Moving Average VaR (EWMAVaR), to advanced models such as GARCH(1,1). We test these models by examining the extremely volatile FX market of the Turkish Lira (TRY) and we evaluate the models according to the criteria set by the legal framework on VaR. The empirical findings suggest that the HVaR model is a very reliable model if the goal of a risk manager is to satisfy the legislation requirements. However, we should mention that models that make use advances in econometrics lead to more accurate and more representative VaR estimations than the HVaR. The law should give incentives to adopt more representative models in the financial industry in order to take advantage of advances in financial modeling.

JEL Classification: C53; G15
Keywords: Value-at-risk; GARCH estimation; Historical VaR; Variance Covariance; Exponential Weighted Moving Average VaR; Back-testing; Legislation; FX Market