bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 5‐km gridded product development of daily temperature and precipitation for Bangladesh, Nepal, and Pakistan from 1981 to 2016
Authors: Ali Shaukat , Bhutta Zulfiqar A. , Reboita Michelle S. , Goheer Muhammad Arif , Ebrahimi Shiva , Rozante Jose Roberto , Kiani Rida S. , Muhammad Sher , Khan Firdos , Rahman Md Mizanur , Shreshta Madan L. , Dan Li 
Published: September 2023

AbstractMany efforts have been made by the scientific community to produce gridded datasets with high spatial resolution because they are essential for climate change assessment, impact studies, decision‐making, etc. This study fits into this context and describes the methods used to prepare a 5‐km gridded product of precipitation and minimum and maximum temperatures by merging observed data from meteorological stations, from 1981 to 2016, of Bangladesh, Nepal, and Pakistan with ERA5 reanalysis. The step‐by‐step methods for station data quality control and the development of the 5‐km gridded data are presented. Additionally, we use the 5‐km dataset to show the main climate features of the three countries, which facilitate comparison with other data sources in the literature.
Inhibiting astrocyte connexin‐43 hemichannels blocks radiation‐induced vesicular VEGF‐A release and blood–brain barrier dysfunction
Authors: Schumacher Steffi , Tahiri Hanane , Ezan Pascal , Rouach Nathalie , Witschas Katja , Leybaert Luc 
Published: September 2023

AbstractTherapeutic brain irradiation with ionizing radiation exerts multiple side effects including barrier leakage that disturbs glial‐neuronal functioning and may affect cognition. Astrocytes contribute to barrier leakage by endfeet release of various vasoactive substances acting on capillary endothelial cells forming the barrier. Here, we investigated X‐ray effects on astrocytic vesicular transport in mice and determined whether interfering with astrocyte connexins affects radiation‐induced barrier leakage. We found that astrocytic VEGF‐A‐loaded VAMP3 vesicles drastically reorganize starting from 6 h post‐irradiation and move in a calcium‐ and Cx43‐dependent manner towards endfeet where VEGF‐A is released, provoking barrier leakage. Vesicular transport activation, VEGF‐A release and leakage 24 h post‐irradiation were all potently inhibited by astrocytic Cx43 KO, Cx43S255/262/279/282A (MK4) mutant mice and TATGap19 inhibition of Cx43 hemichannel opening. Astrocyte VEGF release is a major player in complications of brain irradiation, which can be mitigated by anti‐VEGF treatments. Targeting Cx43 hemichannels allows to prevent astrocyte VEGF release at an early stage after brain irradiation.
Challenges in co‐produced dementia research: A critical perspective and discussion to inform future directions
Authors: Warran Katey , Greenwood Frankie , Ashworth Rosalie , Robertson Martin , Brown Paula 
Published: September 2023

Key points

There is a move towards meaningful collaboration of people living with dementia in the research process, but these processes are rarely critiqued, with more critical reflection needed.
Current academic structures, frameworks, and funding processes limit meaningful collaboration, particularly in relation to academic language and hierarchies of evidence.
There is a need for an environment that can enable the collaboration that is at the heart of a co‐produced ethos, but creating such an environment of reciprocity in dementia research requires extensive time, resources and emotional support.
It is important to embrace the tensions of the contexts we, as researchers, work within and continue to strive towards learning and growth, and fairer and more equitable ways of working in co‐produced dementia research.
How can human factors close the gender data gap?
Authors: Parnell Katie J. , Plant Katherine L. 
Published: September 2023

AbstractThis commentary paper will describe how the discipline of human factors and ergonomics (HFE) can help to close the gender data gap, which is prevalent across many domains and arises due to a lack of data capturing female metrics and viewpoints. HFE is a domain‐independent discipline that seeks to understand human performance and well‐being with respect to the interactions that humans engage in and the environments that they inhabit. HFE therefore presents an opportunity to understand how gender influences human performance, effective design, social interactions, and environmental factors. This paper argues that a sociotechnical systems approach is essential when reviewing equality, diversity, and inclusivity issues, without which attempts to close the gender data gap will not go far enough. Following the sociotechnical systems approach in HFE, the micro‐, meso‐, and macro‐levels of system design with respect to closing the gender data gap are reviewed. We discuss these issues in relation to a case study example of a crash test dummy. A checklist approach for researchers is presented, which identifies key questions that prompt where gender should be considered in the research process across these levels of sociotechnical systems.
Appendicitis and its associated mortality and morbidity in infants up to 3 months of age: A systematic review
Authors: The Sarah‐May M. L. , The Anne‐Fleur M. H. , Derikx Joep P. M. , Bakx Roel , Visser Douwe H. , de Meij Tim G. J. , Ket Johannes C. F. , van Heurn Ernest L. W. , Gorter Ramon R. 
Published: September 2023

AbstractBackground and AimsAlthough appendicitis is rare in young infants, the reported mortality is high. Primary aim of this systematic review was to provide updated insights in the mortality and morbidity (postoperative complications, Clavien‐Dindo grades I–IV) of appendicitis in infants ≤3 months of age. Secondary aims comprised the evaluation of patient characteristics, diagnostic work‐up, treatment strategies, comorbidity, and factors associated with poor outcome.MethodsThis systematic review was reported according to the PRISMA statement with a search performed in Pubmed, Embase and Web of Science (up to September 5th 2022). Original articles (published in English ≥1980) reporting on infants ≤3 months of age with appendicitis were included. Both patients with abdominal appendicitis and herniated appendicitis (such as Amyand's hernia) were considered. Data were provided descriptively.ResultsIn total, 131 articles were included encompassing 242 cases after identification of 4294 records. Overall, 184 (76%) of the 242 patients had abdominal and 58 (24%) had herniated appendicitis. Two‐hundred (83%) of the patients were newborns (≤28 days) and 42 (17%) were infants between 29 days and ≤3 months of age. Either immediate, or after initial conservative treatment, 236 (98%) patients underwent surgical treatment. Some 168 (69%) patients had perforated appendicitis. Mortality was reported in 20 (8%) patients and morbidity in an additional 18 (8%). All fatal cases had abdominal appendicitis and fatal outcome was relatively more often reported in newborns, term patients, patients with relevant comorbidity, nonperforated appendicitis and those presented from home.ConclusionMortality was reported in 20 (8%) infants ≤3 months of age and additional morbidity in 18 (8%). All patients with fatal outcome had abdominal appendicitis. Several patient characteristics were relatively more often reported in infants with poor outcome and adequate monitoring, early recognition and prompt treatment may favour the outcome.
MHD dissipative flow past a permeable vertical plate in a porous medium in the presence of constant heat, mass flux, and diffusion‐thermo effect
Authors: Khanam Masuma , Ahmed Nazibuddin 
Published: September 2023

AbstractAn analytical study of heat and mass transport in magnetohydrodynamic convective flow over an indefinitely long porous plate, which is vertically immersed in the porous medium, is investigated when heat sink, diffusion‐thermo, and thermal radiation are present. A magnetic field with uniform strength has been applied transversely directed into the fluid region. Analysis of diffusion‐thermo impact within the flow problem with constant heat and constant mass flux in the presence of thermal radiation and heat sink is the novelty of the current work. By using the Eckert number E as the perturbation parameter, the regular perturbation approach is used to solve nondimensional governing equations. On the flow and transport characteristics, the effects of Prandtl number, Grashof number, Eckert number, Dufour number, Schmidt number, radiation, magnetic field, and heat sink parameter have been investigated graphically and in tabular form, respectively. The innovative aspect of the current study is the inclusion of the Dufour effect, in addition to constant heat and mass flux at the plate. The Dufour effect can be utilized to improve separation processes, such as distillation, extraction, and chromatography. When the Dufour number and radiation parameter increase, the fluid velocity increases, and while the heat sink parameter increases, it decreases. As dissipation increases, the velocity of the fluid also increases. The concentration of the fluid is enhanced as mass diffusivity increases. When the heat absorption sink grows, the temperature of the fluid decreases.
Use of dry bean fields by birds and mammals in Brazil: Insights from a field study and its use in pesticide risk assessment
Authors: Santos Gustavo Souza , Artal Mariana Coletty , Paniago Mario del Giudice , Cione Ana P. Paola , Casallanovo Fábio , Farrelly Eamonn , Kragten Steven , Maul Jonathan D. 
Published: September 2023

Abstract
The relationship between agriculture and wildlife can be both synergetic and challenging, as the increased surface of agricultural land makes it increasingly important for agriculture and wildlife to coexist. This study aims to describe the use of freshly drilled dry bean fields by birds and mammals in Brazilian Cerrado and Atlantic Forest sites and their diversity and abundance within in-crop and off-crop areas (with native permanent vegetation and other surrounding crop fields) at four different farms. A comprehensive survey was conducted, using various sampling methods, including point counts, foraging counts, trail cameras, and occasional encounters. In all, contacts for 12 518 birds across 306 species and 313 mammals across 34 species were registered. The off-crop areas exhibited greater species richness, abundance, and diversity than the in-crop areas on all farms. For birds, 47 species were recorded in-crop, of which 15 were classified as insectivores, 15 as granivores, seven as omnivores, seven as carnivores, and three as frugivores. The number of in-crop observations per species was small. The abundance off-crop was greater for 31 species observed in-crop, indicating that dry bean fields are probably not a preferred habitat for those species. Species classified as granivorous are most likely to feed on dry bean seeds. However, almost all granivorous species observed in-crop areas are too small to be able to feed on dry bean seeds. For mammals, nine species were recorded in-crop, of which four were classified as carnivores, three as omnivores, one as insectivore, and one as granivore. Additionally, despite the considerable effort in this study, no evidence was found that birds and mammals feed on dry bean seeds. The results highlight the importance of off-crop areas in dry bean fields, characterized by a more diverse and abundant bird community than in-crop. Integr Environ Assess Manag 2024;20:864–874. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Metastasis and recurrence patterns in the molecular subtypes of urothelial bladder cancer
Authors: Sjödahl Gottfrid , Eriksson Pontus , Holmsten Karin , Abrahamsson Johan , Höglund Mattias , Bernardo Carina , Ullén Anders , Liedberg Fredrik 
Published: September 2023

AbstractUrothelial cancer of the urinary bladder frequently metastasizes to lymph‐nodes, lungs, liver and bone. A taxonomy for molecular classification exists, but it is unknown if molecular subtypes show tropism for different organs. Here, we study 146 patients with de novo metastatic disease or recurrence after curative treatment. We classify primary tumors using two transcriptomic methods and immunostaining and identify enrichment and depletion of metastatic sites in molecular subtypes using permutation tests. We observed significant depletion of bone metastases in the Basal/squamous molecular subtype, whereas the Urothelial‐like subtype entailed an enrichment for metastases to bone. The Genomically unstable subtype was depleted of lung metastases, but enriched for atypical sites, including six out of seven patients with brain metastases. Stroma‐rich primary tumor samples were associated with local recurrence, but not with distant sites. Additionally, the proportion with brain or testis metastases differed between systemic chemotherapy regimens (GC vs MVAC) suggesting a sanctuary effect. In conclusion, molecular subtypes of urothelial bladder cancer are significantly associated with specific metastatic sites, suggesting that subtype‐specific molecular determinants could exist at various steps in the metastatic cascade.
The symbiotic effect of osteoinductive extracellular vesicles and mineralized microenvironment on osteogenesis
Authors: Holkar Ketki , Kale Vaijayanti , Pethe Prasad , Ingavle Ganesh 
Published: September 2023

AbstractThe increasing prevalence of bone‐related diseases has raised concern about the need for an osteoinductive and mechanically stronger scaffold‐based bone tissue engineering (BTE) alternative. A mineralized microenvironment, similar to the native bone microenvironment, is required in the scaffold to recruit and differentiate local mesenchymal stem cells at the bone defect site. Further, extracellular vesicles (EVs), pre‐osteoblasts' secretome, contain osteoinductive cargo and have recently been exploited in bone regeneration. This work developed a cell‐free and mechanically strong interpenetrating network‐based scaffold for BTE by combining the action of osteoinductive EVs with a mineralized microenvironment. The MC3T3 (a pre‐osteoblast cell line) is used as a source of EVs and as the target population. The optimal concentration of MC3T3‐EVs was first determined to induce osteogenesis in target cells. The osteoinductive potential of the scaffold was estimated in vitro by osteogenesis‐related markers like the alkaline phosphatase (ALP) enzyme and calcium content. The MC3T3‐EVs cargo was also studied for osteoinductive signals such as ALP, calcium, and mRNA. The findings of this work indicated that MC3T3‐EVs at a 90 μg/mL dose had significantly higher ALP activity than 0 μg/mL (1.47‐fold), 10 μg/mL (1.41‐fold), and 30 μg/mL (1.39‐fold) EV‐concentration on day 14. Further combination of the optimum dose of EVs with a mineralized microenvironment significantly enhanced ALP activity (1.5‐fold) and mineralization (3.36‐fold) as compared to the control group on day 7. EV cargo analysis revealed the presence of calcium, the ALP enzyme, and the mRNAs necessary for osteogenesis and angiogenesis. ALP activity was significantly boosted in the EV‐containing target cells as early as day 1, and mineralization began on day 7 because MC3T3‐EVs carry ALP enzymes and calcium as cargo. When osteoinductive EVs were combined with an osteoconductive mineralized microenvironment, osteogenesis was significantly enhanced in target cells at early time points. The interaction between osteoinductive EVs and the mineralized milieu facilitates the process of osteogenesis in the target cells and suggests a potential cell‐free strategy for in vivo bone repair.
Vasomotion in human arteries and their regulations based on ion channel regulations: 10 years study
Authors: Kim Dae Hoon , Choi Jin Young , Kim Su Mi , Son Seung‐Myoung , Choi Song‐Yi , Koo Beommo , Rah Cheong‐Sil , Nam Ji Hyun , Ju Moon Jin , Lee Jong Sung , You Ra Young , Hong Seung Hwa , Lee Junyoung , Bae Jang‐Whan , Kim Chan Hyung , Choi Woong , Kim Hun Sik , Xu Wen‐Xie , Lee Sang Jin , Kim Young Chul , Yun Hyo‐Yung 
Published: September 2023

AbstractVasomotion is the oscillation of vascular tone which gives rise to flow motion of blood into an organ. As is well known, spontaneous contractile organs such as heart, GI, and genitourinary tract produce rhythmic contraction. It imposes or removes pressure on their vessels alternatively for exchange of many substances. It was first described over 150 years ago, however the physiological mechanism and pathophysiological implications are not well understood. This study aimed to elucidate underlying mechanisms and physiological function of vasomotion in human arteries. Conventional contractile force measurement, immunohistochemistry, and Western blot analysis were employed to study human left gastric artery (HLGA) and uterine arteries (HUA). RESULTS: Circular muscle of HLGA and/or HUA produced sustained tonic contraction by high K+ (50 mM) which was blocked by 2 µM nifedipine. Stepwise stretch and high K+ produced nerve‐independent spontaneous contraction (vasomotion) (around 45% of tested tissues). Vasomotion was also produced by application of BayK 8644, 5‐HT, prostagrandins, oxytocin. It was blocked by nifedipine (2 µM) and blockers of intracellular Ca2+ stores. Inhibitors of Ca2+‐activated Cl− channels (DIDS and/or niflumic acid) and ATP‐sensitive K+ (KATP) channels inhibited vasomotion reversibly. Metabolic inhibition by sodium cyanide (NaCN) and several neuropeptides also regulated vasomotion in KATP channel‐sensitive and ‐insensitive manner. Finally, we identified TMEM16A Ca2+‐activated Cl− channels and subunits of KATP channels (Kir 6.1/6.2 and sulfonylurea receptor 2B [SUR2B]), and c‐Kit positivity by Western blot analysis. We conclude that vasomotion is sensitive to TMEM16A Ca2+‐activated Cl− channels and metabolic changes in human gastric and uterine arteries. Vasomotion might play an important role in the regulation of microcirculation dynamics even in pacemaker‐related autonomic contractile organs in humans.
Partial denitrification in domestic sewage and nitrate wastewater: study of the initiation, influencing factors and operational performance
Authors: Ma Yanhong , Qin Yanrong , Chen Yongzhi , Liu Hong , Wu Xinbo , LÜ Xintao , Yuan Zhongling , Li Weiwei 
Published: September 2023

AbstractBACKGROUNDPractical application of the anaerobic ammonium oxidation (anammox) process has been limited by the difficulty of obtaining a stable supply of NO2−–N. In this study, partial denitrification was utilized as a novel approach to obtain nitrite for anammox, investigating the initiation, influencing factors and performance of partial denitrification in the simultaneous treatment of domestic sewage and nitrate wastewater.RESULTSWhen the influent concentration of NO3−–N was 40 mg L−1 and the chemical oxygen demand to nitrate (COD/NO3−–N) ratio was 2.7, the NO2−–N accumulation rate exceeded 80%, with an effluent NO2−–N concentration of 35.64 mg L−1. Furthermore, the partial denitrification performance was good. When the volume ratio of domestic sewage and nitrate wastewater was adjusted to 2:3 and sodium acetate was added to form a COD/NO3−–N ratio of 3.6, the effluent NO2−–N/NH4+–N ratio was 1.24 and the effluent NO2−–N concentration and average NO2−–N accumulation rate reached >31.24 mg L−1 and 83.38%, respectively, effectively ensuring influent requirements for anammox.CONCLUSIONThe NO3−–N reduction rate, NO3−–N removal rate and NO2−–N accumulation rate were positively correlated with the influent nitrate concentration when ranging between 15 and 40 mg L−1. An appropriate increase in the influent COD/NO3−–N ratio was conducive to a reduction in the time required for maximum levels of NO2−–N accumulation to occur, with an influent NO3−–N concentration of 40 mg L−1. The partial denitrification system could simultaneously treat domestic sewage and nitrate wastewater, effectively ensuring that the generated effluent met the influent requirements for subsequent anammox. © 2023 Society of Chemical Industry.
Magnetic Resonance Imaging‐Based Classification Systems for Informing Better Outcomes of Adenomyosis After Ultrasound‐Guided High‐Intensity Focused Ultrasound Ablating Surgery
Authors: Tang Ying , Hu Wen‐hao , Wang Hang , Wu Jia , Wen Ming‐bo , Su Bin , Jiang Zhi‐jun , Jiang Xiao , Zhu Li‐juan , Ding Na , Yang Ming‐tao , Yin Shu , Hu Hui‐quan , Xu Fan , Li Jun , Shi Qiuling 
Published: September 2023

BackgroundA referenced MRI‐based classification associated with focused ultrasound ablation surgery (FUAS) outcomes is lacking in adenomyosis.PurposeTo identify an MRI‐based classification system for informing the FUAS outcomes.Study TypeRetrospective.PopulationPatients with FUAS for adenomyosis, were divided into a training set (N = 643; 355 with post‐FUAS gonadotropin‐releasing hormone/levonorgestrel, 288 without post‐FUAS therapy) and an external validation set (N = 135; all without post‐FUAS therapy).Field Strength/Sequence1.5 T, turbo spin‐echo T2‐weighted imaging and single‐shot echo‐planar diffusion‐weighted imaging sequences.AssessmentFive MRI‐based adenomyosis classifications: classification 1 (C1) (diffuse, focal, and mild), C2 (intrinsic, extrinsic, intramural, and indeterminate), C3 (internal, adenomyomas, and external), C4 (six subtypes on areas [internal or external] and volumes [<1/3 or ≥2/3]), and C5 (internal [asymmetric or symmetric], external, intramural, full thickness [asymmetric or symmetric]) for FUAS outcomes (symptom relief and recurrence).Statistical TestsThe optimal classification was significantly associated with the most subtypes of FUAS outcomes. Relating to the timing of recurrence was measured using Cox regression analysis and median recurrence time was estimated by a Kaplan–Meier curve. A P value <0.05 was considered statistically significant.ResultsDysmenorrhea relief and recurrence were only associated with C2 in training patients undergoing FUAS alone. Compared with other subtypes, the extrinsic subtype of C2 was significantly associated with dysmenorrhea recurrence in the FUAS group. Besides, the median dysmenorrhea recurrence time of extrinsic subtype was significantly shorter than that of other subtypes (42.0 months vs. 50.3 months). In the validation cohort, C2 was confirmed as the optimal system and its extrinsic subtype was confirmed to have a significantly shorter dysmenorrhea recurrence time than other subtypes.Data ConclusionClassification 2 can inform dysmenorrhea relief and recurrence in patients with adenomyosis undergoing FAUS only. Itsextrinsic subtype was associated with an earlier onset of dysmenorrhea recurrence after treatment.Evidence Level3Technical EfficacyStage 5