bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depth of Invasion in Carcinoma Tongue: Evaluation of Clinical and Imaging Techniques
Authors: Kumar Rajeev , Sherif Mohammad Ponneth , Manchanda Smita , Barwad Adarsh , Sagar Prem , Khan Maroof Ahmad , Bhalla Ashu Seith , Singh Chirom Amit , Kumar Rakesh 
Published: May 2023

Background“Depth of invasion” is an additional index incorporated in 8th AJCC staging system for oral cavity squamous cell carcinoma based on its prognostic significance. Pre‐operative assessment by clinical palpation and imaging modalities has been used with limitations. The aim of the study is to compare different techniques including clinical palpation, ultrasound, and magnetic resonance imaging with histopathology for assessment of depth of tumor invasion.MaterialsFifty patients of carcinoma tongue (T1–T3) were enrolled. Clinical palpation, Ultrasound tongue, and Magnetic resonance imaging were used to assess depth of tumor invasion. Microscopic depth of invasion was considered as reference. Statistical analysis was done to assess the level of agreement, reliability, and internal consistency. ROC analysis was done to find the “Area Under Curve” for microscopic depth versus ultrasound, MRI, and gross histopathological “depth of invasion”.ResultsUltrasound tongue showed highest “area under curve”, Intra class correlation (ICC:0.786) with a good consistency (Cronbach's Alpha:0.880) with histological reference compared to MRI(ICC:0.689;CA:0.816). Clinical palpation showed weak agreement (Kappa:0.43) for assessing depth. To observe the concordance between ultrasound and microscopic depth, Lin's Concordance Correlation Coefficient (CCC = 0.782) was calculated with 95% limits of agreement. Lin's concordance correlation between ultrasound and microscopic depth showed a good agreement.ConclusionsUltrasound tongue is a reliable imaging modality for pre‐operative T staging by assessing tumor “depth of invasion” in carcinoma tongue patients with good internal consistency as per 8th AJCC staging system.Level of Evidence2 (CEBM‐Level of Evidence‐2.1) Laryngoscope, 134:215–221, 2024
Opening research data contributes to the citations of related research articles: Evidence from Data in Brief
Authors: Fu Jiangyang , Tian Liang , Zhang Chengzhi , Li Jiang 
Published: May 2023

AbstractThis paper explores the effect of publishing a data paper in the Open Access journal Data in Brief (DIB) on the citation counts of the related research paper. Using regression analysis, citation content analysis and a survey method, we investigate whether research papers with a related data paper have higher citation counts and the potential reasons. After controlling variables that correlate with the citation counts, research papers with a related data paper were found to have higher citation counts than those published in the same issue of the same journal. Next, we explored the causal relationship between the two variables by surveying the corresponding authors of 618 papers who shared datasets in DIB from 2014 to 2021. The results show that the authors acknowledge the benefits of sharing data in DIB, including citation increase and career reputation enhancement. We further explored how the data papers in DIB increase the citations of the related research papers by using citation content analysis. We found that scientists co‐cite the data papers and their related research papers for the purpose of reusing the underlying data or portraying a better understanding of the underlying data and related research articles.
Experimental nutrient enrichment of forest streams reduces ecosystem nitrogen and phosphorus storage
Authors: Bumpers Phillip M. , Rosemond Amy D. , Manning David W. P. , Kominoski John S. , Benstead Jonathan P. , Demi Lee M. 
Published: May 2023

AbstractStreams store nutrients in standing stocks of organic matter (OM) and associated biologically sequestered elements. Unlike standing stocks of autotrophs, detritus is depleted by nutrient enrichment, potentially reducing areal storage of detritus‐associated nutrients. To test effects of nutrient‐loading on storage of nitrogen (N) and phosphorus (P) by autotrophic and detrital‐pool compartments, we quantified the effects of 2 yr of continuous experimental N and P additions on fine benthic organic matter (FBOM), leaves, wood, and biofilms in five forest streams. Our design tested the relative strength of N vs. P on OM nutrient content, areal OM storage, and areal nutrient storage in OM types. Enrichment increased nutrient content of all OM types; %P increased more than %N in leaves, wood, and biofilms, but not FBOM. Biofilm %P and %N increased more than in all detrital types. Areal FBOM and leaf storage declined with nutrient enrichment. Biofilm standing stocks were generally higher with enrichment but were not related to the streamwater N and P gradients. Despite increased OM nutrient content, total areal nutrient storage in leaves and wood decreased due to reduced OM storage. Although annual nutrient storage was stabilized by FBOM, seasonal variation in nutrient storage increased with enrichment. Leaf‐associated nutrient storage was reduced in most seasons, whereas FBOM and biofilm nutrient storage increased in winter and spring, respectively, relative to pretreatment. Overall, the combined responses of all OM types to enrichment resulted in reduced storage and altered seasonal availability of carbon and nutrients, which has implications for consumers and downstream processes.
Reconstructing missing data by comparing interpolation techniques: Applications for long‐term water quality data
Authors: Larson Danelle M. , Bungula Wako , Lee Amber , Stockdill Alaina , McKean Casey , Miller Frederick "Forrest" , Davis Killian , Erickson Richard A. , Hlavacek Enrika 
Published: May 2023

AbstractMissing data are typical yet must be addressed for proper inferences or expanding datasets to guide our limnological understanding and management of aquatic systems. Interpolation methods (i.e., estimating missing values using known values within the dataset) can alleviate data gaps and common problems. We compared seven popular interpolation methods for predicting substantial missingness in a long‐term water quality dataset from the Upper Mississippi River, U.S.A. The dataset included 80,000 sampling sites collected over 30 yr that had substantial missingness for total nitrogen (TN), total phosphorus (TP), and water velocity. For all three interpolated water quality variables, random forests had very high prediction accuracy and outperformed the methods of ordinary kriging, polynomial regressions, regression trees, and inverse distance weighting. TP had a mean absolute error (MAE) of 0.03 mg (L‐TP)−1, TN had a MAE of 0.39 mg (L‐TN)−1, and water velocity had a MAE of 0.10 m s−1. The random forests' error rates were mapped and showed low spatiotemporal variability across the riverscape, indicating high model performance across many habitat types and large spatial scales. In the current era of “big data,” interpolation becomes an imperative step prior to ecological analyses yet remains unfamiliar and underutilized. Our research briefly describes the importance of addressing missingness and provides a roadmap to conduct model intercomparisons of other big datasets. We also share adaptable data analysis scripts, which allows others to readily conduct interpolation comparisons for many limnology applications and contexts.
Regular dynamics of stochastic nondissipative retarded Kuramoto–Sivashinsky equations
Authors: Zhang Qiangheng 
Published: May 2023

AbstractThe theme of this paper is to study the long‐term behavior of stochastic nondissipative Kuramoto–Sivashinsky (KS) equations with time‐dependent force and abstract delays. We first introduce an odd function to overcome the nondissipation of this equation. We then use the spectrum decomposition technique to prove the existence and regularity of a unique pullback random attractor (PRA), and establish the measurability, forward compactness, and long‐time stability of PRAs in the regular space. Finally, we consider the upper semicontinuity of PRAs in the regular space from nonautonomy to autonomy. Moreover, we provide three concrete examples for the general delay term.
Potentiated effects of lactate receptor GPR81 on immune microenvironment in breast cancer
Authors: Guo Shenchao , Zhou Jianliang , Lou Pengrong , Weng Lijuan , Ye Xiaoxian , Guo Jianxin , Liu Huan , Ma Ruishuang 
Published: May 2023

AbstractG protein‐coupled receptor (GPR81), as lactate receptor, is an upstart in immune regulation, however, its mechanisms involved in tumor escape have not been fully elucidated. In this study, we explored the effects of GPR81 activation on triple‐negative breast cancer (TNBC) cells and macrophages. The expression and relationship with immune infiltration of GPR81 were analyzed with TCGA database. Checkpoints and cytokines were evaluated with flow cytometry or ELISA. The TCGA‐based data showed a marked decrease of GPR81 in breast cancer (BRCA) compared with normal breast, especially in the basal‐like subtype. In normal mammary tissues, GPR81 had negative correlation with various immune checkpoints, nevertheless, this trend weakened accompanied with the reduction of GPR81. GPR81 stimulation had a significantly inhibitory influence on PD‐L1 exposure in BT‐549 and MDA‐MB‐231 cell lines, but not in MDA‐MB‐453 cell line. The pretreatment of siGPR81 to knockdown GPR81 expression resulted in a remitting of PD‐L1 reduction when MDA‐MB‐231 cells were treated with GPR81 agonist 1. However, little effect of GPR81 activation was observed on the expression of PD‐L1 on phorbol‐12‐myristate‐13‐acetate (PMA)‐induced THP‐1 cells. Furthermore, GPR81 agonist 1 exerted no significant impact on the secretion of cytokines in THP‐1 cells. In general, it is suggested that GPR81 may facilitate immune monitoring via the reduction of PD‐L1 in TNBC with glycolytic phenotype. Our results not only provide a novel insight into the effects of GPR81 on immune evasion but a potential therapy targeting GPR81 in BRCA.
Phenotypic Variability in Acquired and Idiopathic Dystonia
Authors: Defazio Giovanni , Gigante Angelo Fabio , Erro Roberto , Belvisi Daniele , Esposito Marcello , Trinchillo Assunta , De Joanna Gabriella , Ceravolo Roberto , Mazzucchi Sonia , Unti Elisa , Barone Paolo , Scannapieco Sara , Cotelli Maria Sofia , Turla Marinella , Bianchi Marta , Bertolasi Laura , Pisani Antonio , Valentino Francesca , Altavista Maria Concetta , Moschella Vincenzo , Girlanda Paolo , Terranova Carmen , Bono Francesco , Spano Giorgio , Fabbrini Giovanni , Ferrazzano Gina , Albanese Alberto , Castagna Anna , Cassano Daniela , Coletti Moja Mario , Pellicciari Roberta , Bentivoglio Anna Rita , Eleopra Roberto , Cossu Giovanni , Ercoli Tommaso , Mascia Marcello Mario , Di Biasio Francesca , Misceo Salvatore , Magistrelli Luca , Romano Marcello , Scaglione Cesa Lorella Maria , Tinazzi Michele , Maderna Luca , Zibetti Maurizio , Berardelli Alfredo 
Published: May 2023

AbstractBackgroundTo date, a few studies have systematically investigated differences in the clinical spectrum between acquired and idiopathic dystonias.ObjectivesTo compare demographic data and clinical features in patients with adult‐onset acquired and idiopathic dystonias.MethodsPatients were identified from among those included in the Italian Dystonia Registry, a multicenter Italian dataset of patients with adult‐onset dystonia. Study population included 116 patients with adult‐onset acquired dystonia and 651 patients with isolated adult‐onset idiopathic dystonia.ResultsComparison of acquired and idiopathic dystonia revealed differences in the body distribution of dystonia, with oromandibular dystonia, limb and trunk dystonia being more frequent in patients with acquired dystonia. The acquired dystonia group was also characterized by lower age at dystonia onset, greater tendency to spread, lower frequency of head tremor, sensory trick and eye symptoms, and similar frequency of neck pain associated with CD and family history of dystonia/tremor.ConclusionsThe clinical phenomenology of dystonia may differ between acquired and idiopathic dystonia, particularly with regard to the body localization of dystonia and the tendency to spread. This dissimilarity raises the possibility of pathophysiological differences between etiologic categories.
Using item response theory to develop a shortened practice environment scale of the nursing work index
Authors: Montgomery Aoyjai P. , Campbell Caitlin M. , Azuero Andres , Swiger Pauline A. , Patrician Patricia A. 
Published: May 2023

AbstractThe 31‐item Practice Environment Scale of the Nursing Work Index (PES‐NWI) has been frequently used globally to measure the nurse work environment. However, due to its length and subsequent respondent burden, a more parsimonious version of the PES‐NWI may be desirable. Item response theory (IRT) is a statistical technique that assists in decreasing the number of items in an instrument without sacrificing reliability and validity. Two separate samples of nurses in the United States (one called the “internal data source” and the other called “external data source”; sample sizes = 843 and 722, respectively) were analyzed. The internal data source was randomly split into training (n = 531) and validating data sets (n = 312), while a separate whole external data source was used as the final validating data set. Using IRT with training data, we removed nine items; two additional items were removed based on recommendations from a previous study. Confirmatory factor analyses supported the validity of the measurement model with the 20‐item of PES‐NWI in both internal and external validation data sources. The correlations among subscales between 31‐ and 20‐item versions were high magnitude for five subscales in both validation data sets (τ = 0.84–0.89). Ultimately, we identified a 20‐item version of the PES‐NWI which demonstrated adequate validity and reliability properties while decreasing data collection burden yet maintaining a similar factor structure to the original instrument. Additional research may be necessary to update the items themselves on the PES‐NWI.
Uncovering the Mechanism of Azepino‐Indole Skeleton Formation via Pictet–Spengler Reaction by Strictosidine Synthase: A Quantum Chemical Investigation
Authors: Mou Mingqi , Zhang Chenghua , Zhang Shiqing , Chen Fuqiang , Su Hao , Sheng Xiang 
Published: May 2023

AbstractStrictosidine synthase (STR) catalyzes the Pictet–Spengler (PS) reaction of tryptamine and secologanin to produce strictosidine. Recent studies demonstrated that the enzyme can also catalyze the reaction of non‐natural substrates to form new alkaloid skeletons. For example, the PS condensation of 1H‐indole‐4‐ethanamine with secologanin could be promoted by the STR from Rauvolfia serpentina (RsSTR) to generate a rare class of skeletons with a seven‐membered ring, namely azepino‐[3,4,5‐cd]‐indoles, which are precursors for the synthesis of new compounds displaying antimalarial activity. In the present study, the detailed reaction mechanism of RsSTR‐catalyzed formation of the rare seven‐membered azepino‐indole skeleton through the PS reaction was revealed at the atomic level by quantum chemical calculations. The structures of the transition states and intermediates involved in the reaction pathway were optimized, and the energetics of the complete reaction were analyzed. Based on our calculation results, the most likely pathway of the enzyme‐catalyzed reaction was determined, and the rate‐determining step of the reaction was clarified. The mechanistic details obtained in the present study are important in understanding the promiscuous activity of RsSTR in the formation of the rare azepino‐indole skeleton molecule and are also helpful in designing STR enzymes for the synthesis of other new alkaloid skeleton molecules.
Healthcare utilization and cost barriers among U.S. childhood cancer survivors
Authors: Nghiem Van T. , Alanaeme Chibuike J. , Mennemeyer Stephen T. , Wong F. Lennie 
Published: May 2023

AbstractBackgroundTo evaluate healthcare utilization and cost barrier patterns among childhood cancer survivors (CCS) compared with noncancer controls.ProcedureUsing the 2014‐2019 Behavioral Risk Factor Surveillance System, we identified CCS < 50 years and matched controls. We used chi‐squared tests to compare characteristics between the two groups. Logistic regression analyses were used to assess the likelihood of having a checkup, receiving influenza vaccine, and experiencing healthcare cost barriers (being unable to see the doctor due to cost) during the past 12 months. Conditional models accounted for the matching.ResultsWe included 231 CCS and 692 controls. CCS had lower household income (p < 0.001), lower educational attainment (p = 0.021), more chronic health conditions (p < 0.001), and a higher proportion of being current smokers (p = 0.005) than controls. Both groups had similar rates of having a checkup and influenza vaccine; however, a quarter of CCS experienced healthcare cost barriers compared with 13.9% in controls (p = 0.001; regression findings: adjusted odds ratio (aOR) = 1.72, 95% confidence interval (CI): 1.11‐2.65). Compared with the youngest CCS group (18‐24 years), CCS ages 25‐29 years were five times more likely to experience healthcare cost barriers (aOR = 4.79; 95% CI, 1.39‐16.54). Among CCS, current smokers were less likely to have a checkup (aOR = 0.46; 95% CI, 0.23‐0.94). Uninsured CCS were less likely to have a checkup (aOR = 0.33; 95% CI, 0.14‐0.75) and ∼8 times more likely to experience healthcare cost barriers (aOR = 8.28; 95% CI, 3.45‐19.88).ConclusionCCS being 25‐29 years, uninsured, or current smokers encounter inferior outcomes in healthcare utilization and cost barriers. We suggest emphasis on programs on care transition and smoking cessation for CCS.
The effect of alternating the sequence of variable‐energy repeated impact on the residual strength and damage evolution of composite laminates
Authors: Saeedifar Milad , Saleh Mohamed Nasr 
Published: May 2023

AbstractThis article investigates the effect of alternating the sequence of variable‐energy repeated low‐velocity impact on the residual strength of carbon fiber reinforced polymer (CFRP) laminates. Quasi‐isotropic CFRP specimens were impacted using three impact energy levels, that is, Low (L), Medium (M), and High (H). Every group, out of three groups in total, was impacted consecutively using one of three sequences: LMH, HML, and MLH. Delamination and its growth after each impact was quantified using a phased‐array ultrasonic probe. The impacted specimens were then subjected to compression after impact loading with in situ acoustic emission (AE) and digital image correlation (DIC) measurement. Mechanical results showed that the residual strength of the specimens was not significantly affected by alternating the impacts sequence. However, the AE, sentry function and DIC results revealed that the impact‐induced damage in HML configuration was activated much earlier than MLH, and the damage induced in LMH configuration was activated later than both.
Identifying patients with diabetes in a day‐case systemic anti‐cancer therapy population: the Belfast Regional Oncology Centre experience
Authors: Waterworth Adam , Hamilton Ashleigh , Johnston Philip , Todd Anna , Connolly Grainne , Nugent Ailish , Scullin Paula , McKenna Sarah , Lawless Sarah , Wallace Helen , Wallace Ian 
Published: May 2023

AbstractPatients undergoing systemic anti‐cancer treatment (SACT) often receive short courses of high dose steroids which may cause hyperglycaemia and potentially impact negatively on clinical outcomes. In this study we aimed to ascertain the prevalence of diabetes in a day‐case SACT cohort and secondly to compare practical methods of identifying patients with diabetes in a busy oncology service.We performed two prospective snapshots of all patients attending for day‐case SACT at the Regional Oncology Centre, Belfast, over two separate week‐long periods. In the first snapshot we evaluated laboratory random serum glucose concentration. Data from 221 patients identified 14 patients with elevated random serum glucose (≥11.1mmol/L). In the second snapshot we added a patient questionnaire asking if the patient had diabetes alongside laboratory random serum glucose concentrations. We obtained 242 completed questionnaires from a potential of 299 (81% response rate) patients; 54 (22%) had known diabetes. By laboratory data, only 17 of 242 (7%) had a random serum glucose concentration ≥11.1mmol/L. All 17 would have been identified by asking the patient if they had diabetes. Diabetes is common in this cohort (22%). In a busy oncology clinic, the most effective way to identify patients with diabetes is to ask them first if they have diabetes.This study is timely given the recent publication of Joint British Diabetes Societies and United Kingdom Chemotherapy Board guidance to improve the glycaemic control of patients with cancer. Earlier diagnosis and subsequent intervention to improve glycaemic control have the potential to improve clinical outcomes. Copyright © 2023 John Wiley & Sons.
Adding psychology to the diabetes service ‘new patient’ pathway: an evaluation
Authors: Heath Jennifer 
Published: May 2023

AbstractPromotion of psychology as an integrated aspect of the diabetes team has been encouraged, with the aims of: reducing stigma felt by service users accessing this aspect of the multidisciplinary team, allowing for a biopsychosocial overview of patient care, and timely advising on appropriate signposting and onwards referral where necessary. To this end, a new care pathway was trialled, with psychology appointments offered as the third step in a new nurse‐ and dietitian‐led clinic structure.For a five‐month trial period, all new patients (newly diagnosed or new to the service, n=30) were allocated a 30‐minute‐long remote psychology assessment appointment. The attendance rate was 66.7% and comparable with traditional opt‐in psychology appointments. Attendance at psychology appointments was not influenced by diabetes type; however, patients were more likely to attend if they were female or of British ethnicity.The trial suggested that psychology appointments can be integrated into the preliminary assessment and annual review system without the need for specific referral. Such assessments can offer space for patients to reflect on their experience of living with diabetes and the identification of any psychosocial support needs, enabling timely information sharing and referral for support within and beyond the multidisciplinary team. Further evaluation is necessary to ascertain whether integrated psychological assessments in the usual care pathway can promote better awareness of, and engagement with, psychology while patients are under the care of the diabetes team. Copyright © 2023 John Wiley & Sons.