bluuebunny/crossref_metadata_2025_split huggingface dataset:
Berücksichtigung von Komorbiditäten in der Wirksamkeitsforschung zu Depressionsbehandlungen – ein narratives Review
Authors: Trinkler Catharina , Strauß Bernhard , Gumz Antje 
Published: December 2022

Zusammenfassung
Hintergrund
Die Berücksichtigung psychischer Komorbiditäten in der Wirksamkeitsforschung ist aufgrund hoher Komorbiditätsraten bei Depressionen und deren Auswirkungen auf die Behandlungspraxis relevant.

Ziele
Ziel dieses Beitrags ist, die Berücksichtigung von Komorbiditäten in aktuellen Studien zur Wirksamkeit von Depressionsbehandlungen zu untersuchen und die Relevanz eines wissenschaftlichen Einbezugs für die praktische Arbeit mit Depressionen zu betonen.

Methode
In einschlägigen Datenbanken wurde nach deutsch- und englischsprachigen Metaanalysen zum Thema mit einem Veröffentlichungsdatum zwischen 2000 und 2020 gesucht. Zur Prüfung des methodischen Umgangs mit Komorbiditäten in Wirksamkeitsstudien zu Depressionsbehandlungen wurden spezifische Kriterien formuliert. Studien, deren Stichproben wegen einer primär somatischen Erkrankung behandelt wurden, wurden nicht betrachtet.

Ergebnisse
Die Auswertung des methodischen Umgangs mit psychischen Komorbiditäten ergab, dass psychische Komorbiditäten in 4 von 17 Metaanalysen ausreichend berücksichtigt wurden. Drei Studien definierten Komorbiditäten als Ausschlusskriterium, 4 Studien schlossen komorbide Stichproben ein, ohne mögliche Effekte durch Komorbiditäten statistisch zu analysieren, und 6 Studien berücksichtigten Komorbiditäten gar nicht.

Diskussion
Eine ausreichende Berücksichtigung psychischer Komorbiditäten würde die Repräsentativität der Befundlage zur Wirksamkeit von Depressionsbehandlungen steigern und auf dieser Grundlage Potenzial für Qualitätsverbesserungen von Depressionsbehandlungen bieten.
Vestibular migraine or Meniere's disease: a diagnostic dilemma
Authors: Chen Jing-Yu , Guo Zhao-Qi , Wang Jun , Liu Dan , Tian E. , Guo Jia-qi , Kong Wei-Jia , Zhang Su-Lin 
Published: December 2022

AbstractMeniere’s disease (MD) represents one of the vertigo disorders characterized by triad symptoms (recurrent vertigo, fluctuating hearing loss, tinnitus or ear fullness). The diagnosis of MD relies on the accurate and detailed taking of medical history, and the differentiation between MD and vestibular migraine (VM) is of critical importance from the perspective of the treatment efficacy. VM is a highly prevalent vertigo condition and its typical symptoms (headache, vestibular symptoms, cochlear symptoms) mimic those of MD. Furthermore, the misdiagnosis in MD and VM could lead to VM patients mistakenly receiving the traumatic treatment protocol designed for MD, and sustaining unnecessary damage to the inner ear. Fortunately, thanks to the advances in examination technologies, the barriers to their differentiation are being gradually removed. These advances enhance the diagnostic accuracy of vertigo diseases, especially VM and MD. This review focused on the differentiation of VM and MD, with an attempt to synthesize existing data on the relevant battery of differentiation diagnosis (covering core symptoms, auxiliary tests [audiometry, vestibular tests, endolymphatic hydrops tests]) and longitudinal follow-up. Since the two illnesses are overlapped in all aspects, no single test is sufficiently specific on its own, however, patterns containing all or at least some features boost specificity.
“Like one part of a puzzle” — individualized aromatherapy for women with gynecological cancers in aftercare: results from a qualitative-focused mixed-methods study
Authors: Czakert Judith , Stritter Wiebke , Blakeslee Sarah B. , Grabowski Jacek P. , Sehouli Jalid , Seifert Georg 
Published: December 2022

AbstractBackgroundGynecological cancer(s), including breast cancer patients in aftercare and survivors, need supportive strategies to cope with symptoms that are adapted to their individual needs and circumstances. Aromatherapy has potential to be such strategy, but (qualitative) empirical research taking users’ own views into consideration about the potential and challenge of aromatherapy is lacking.PurposeThe purpose of the study is to gain insights from individualized aromatherapy as a supportive care treatment, regarding their use and evaluation by women with gynecological cancers in aftercare.MethodsWe conducted a study with a mixed-methods design, focused on qualitative research. Five essential oil products were given to 18 participants to apply individually over a 4-week period. After the intervention, qualitative semi-structured interviews were conducted. Further, we documented and assessed symptomatic burdens of the women (MYMOP2) before and after intervention quantitatively.ResultsAromatherapy was customized by the participants according to their needs. It showed potential for relief of symptomatic burdens — especially nausea, peripheral neuropathy, pain, and sleep. Additionally, opportunities emerged to indirectly affect symptomatic burdens. These developed out of new coping strategies (e.g., sleep routines) or by combining with existing strategies (e.g., meditation). Furthermore, aromatherapy was successfully used to promote well-being and encourage mindfulness.ConclusionOur findings demonstrated the potential of aromatherapy as a supportive treatment modality that can be used as a kind of toolbox. Challenges, such as individual odor aversions and intolerances, and limitations due to medication or illness should be considered in future aromatherapy research.
A self-training automatic infant-cry detector
Authors: Coro Gianpaolo , Bardelli Serena , Cuttano Armando , Scaramuzzo Rosa T. , Ciantelli Massimiliano 
Published: December 2022

AbstractInfant cry is one of the first distinctive and informative life signals observed after birth. Neonatologists and automatic assistive systems can analyse infant cry to early-detect pathologies. These analyses extensively use reference expert-curated databases containing annotated infant-cry audio samples. However, these databases are not publicly accessible because of their sensitive data. Moreover, the recorded data can under-represent specific phenomena or the operational conditions required by other medical teams. Additionally, building these databases requires significant investments that few hospitals can afford. This paper describes an open-source workflow for infant-cry detection, which identifies audio segments containing high-quality infant-cry samples with no other overlapping audio events (e.g. machine noise or adult speech). It requires minimal training because it trains an LSTM-with-self-attention model on infant-cry samples automatically detected from the recorded audio through cluster analysis and HMM classification. The audio signal processing uses energy and intonation acoustic features from 100-ms segments to improve spectral robustness to noise. The workflow annotates the input audio with intervals containing infant-cry samples suited for populating a database for neonatological and early diagnosis studies. On 16 min of hospital phone-audio recordings, it reached sufficient infant-cry detection accuracy in 3 neonatal care environments (nursery—69%, sub-intensive—82%, intensive—77%) involving 20 infants subject to heterogeneous cry stimuli, and had substantial agreement with an expert’s annotation. Our workflow is a cost-effective solution, particularly suited for a sub-intensive care environment, scalable to monitor from one to many infants. It allows a hospital to build and populate an extensive high-quality infant-cry database with a minimal investment.
Design principles for advancing higher education sustainability learning through transformative research
Authors: Bernert Philip , Wanner Matthias , Fischer Nele , Barth Matthias 
Published: December 2022

AbstractA growing number of transformative research practices that redefine the role of science in engaging with local–mostly urban–transformation processes have emerged in recent decades. However, while education is considered a key driver for sustainability transformations, higher education has been slow to develop and implement dedicated, appropriate and effective transformative education programmes and learning modules. In this paper, we present a framework of design principles for transformative learning modules in higher education. These principles are derived from two growing discourses: higher education sustainability learning, and transdisciplinary and transformative research—both of which are centrally anchored in the field of sustainable development and sustainability science. The principles presented provide guidance for course leaders in higher education to create learning modules aimed at enabling students to become engaged in transdisciplinary and transformative research that fosters sustainability transitions in local and urban contexts. We use the Transformative Innovation Lab (TIL)—a learning course developed and tested at two German universities—as an example of how the design principles can be applied. The module, which runs over two semesters, supports Masters students in their process of developing real-world laboratories and exploring urban sustainability transitions through collaborative experimentation with local practice partners. We discuss the factors that enable and limit the implementation of transformative learning modules and outline aspects of the novel roles adopted by lecturers in transformative teaching environments. Moreover, we highlight the need for both institutional change and transformative teaching formats that go beyond transformative research as key for driving universities to take responsibility for collaboratively fostering sustainability transitions in their local contexts.
Clinical study of acupuncture combined with medication for the elderly with Alzheimer disease
Authors: Pang Jing , Yin Hongna , Sun Zhongren , Xia Kunpeng 
Published: December 2022

Abstract
Objective
To observe the impact of mind-regulating acupuncture plus donepezil on the cognitive ability, mean cerebral blood flow velocity, event-related potential P300, and activities of daily living (ADL) in the aged patients with Alzheimer disease (AD).

Methods
Sixty senile AD patients were divided into a treatment group and a control group following the envelope method for random allocation, with 30 cases in each group. Based on the conventional treatment of the internal medicine, the control group received oral donepezil, and the treatment group received oral donepezil plus mind-regulating acupuncture. After 4-week treatment, the two groups were evaluated by the mini-mental state examination (MMSE), Alzheimer disease assessment scale-cognitive part (ADAS-Cog), and ADL; changes in P300 and the mean cerebral blood flow velocity were also observed.

Results
Before treatment, there were no significant differences in the scores of MMSE, ADAS-Cog, or ADL between the two groups (P>0.05). The MMSE score increased after treatment in both groups and was notably higher in the treatment group than in the control group, showing intra-group and inter-group statistical significance (P<0.05). After treatment, the ADAS-Cog and ADL scores dropped in both groups and were markedly lower in the treatment group than in the control group, also showing intra-group and inter-group statistical significance (P<0.05). Compared with the same group before treatment, the latency of P300 was shortened and the amplitude was extended in both groups, all with statistical significance (P<0.05); the latency was shorter and the amplitude was larger in the treatment group than in the control group after treatment, presenting significant between-group differences (P<0.05). The mean blood flow velocity accelerated after the intervention in both groups, and the differences were statistically significant (P<0.05); the improvement in the treatment group was more notable than that in the control group (P<0.05).

Conclusion
Mind-regulating acupuncture plus donepezil can regulate the latency and amplitude of P300, increase cerebral blood flow, and improve the learning and memory abilities of AD patients.
Randomized cross-over study investigating the tolerability and side effects of an intra-oral air-cooling device compared to ice in healthy volunteers
Authors: Blacker C. , Bejhed R. S. , Frykholm P. , Ljungman G. 
Published: December 2022

AbstractOral cryotherapy (OC) is a common preventive treatment of oral mucositis (OM) and is recommended in international guidelines. Ice and air OC have previously been shown to result in temperature reductions of 8.1–12.9 °C, and 14.5 °C, respectively, in healthy volunteers. However, no direct comparison between these two modalities has been performed. The primary aim was to investigate the tolerability and side effects of air OC using an intra-oral air-cooling (IOAC) device compared with ice OC. The secondary aim was to evaluate the temperature reduction in the mouth for the two respective methods. Cross-over study with randomization to order of treatment, in 15 healthy volunteers. We evaluated the self-reported intensity, frequency, and discomfort for 13 pre-defined side effects used in previous studies. All participants were able to complete both OC sessions, although one participant required reduced airflow in the air OC arm. The subjects reported more discomfort from being cold, having sensitive teeth, and numbness in the ice OC group, while they reported more discomfort from swallowing when subjected to air OC. No significant difference in the median temperature reduction was detected in the two modalities, except for the dorsal posterior part of the tongue where temperature reduction was larger in the ice OC group. We found that oral cooling using a new IOAC device was tolerated and seems to be safe in healthy volunteers.
A Disintegrin and Metalloproteinase 10 (ADAM10) Is Essential for Oligodendrocyte Precursor Development and Myelination in the Mouse Brain
Authors: Guo Dazhi , Huang Fei , Xue Ruijun , Ma Yuehong , Xiao Lin , Lou Huifang , Pan Shuyi 
Published: December 2022

AbstractA disintegrin and metalloproteinase 10 (ADAM10) plays an essential role in the regulation of survival, proliferation, migration, and differentiation of various neural cells. Nevertheless, the role of ADAM10 in oligodendrocyte precursors (OPCs) and myelination in the central nervous system (CNS) of developing and adult mouse brains is still unknown. We generated ADAM10 conditional knockout (ADAM10 cKO) mice lacking the ADAM10 gene primarily in OPCs by crossing NG2-Cre mice with ADAM10loxp/loxpmice. We found that OPCs expressed ADAM10 in the mouse corpus callosum and the hippocampus. ADAM10 cKO mice showed significant loss of back hair and reduction in weight and length on postnatal (30 ± 2.1) day, died at (65 ± 5) days after birth, and exhibited the “anxiety and depression-like” performances. Conditional knockout of ADAM10 in OPCs resulted in a prominent increase in myelination and a decrease in the number of OPCs in the corpus callosum at P30 owing to premyelination and lack of proliferation of OPCs. Moreover, the number of proliferating OPCs and mature oligodendrocytes (OLs) also decreased with age in the corpus callosum of ADAM10 cKO mice from P30 to P60. Western blot and RT-PCR results showed that the activation of Notch-1 and its four target genes, Hes1, Hes5, Hey1, and Hey2, was inhibited in the corpus callosum tissue of ADAM10 knockout mice. In our study, we provided experimental evidence to demonstrate that ADAM10 is essential for modulating CNS myelination and OPC development by activating Notch-1 signaling in the developing and adult mouse brain.
Towards Effective Consensus Scoring in Structure-Based Virtual Screening
Authors: Nhat Phuong Do , Flower Darren R. , Chattopadhyay Subhagata , Chattopadhyay Amit K. 
Published: December 2022

AbstractVirtual screening (VS) is a computational strategy that uses in silico automated protein docking inter alia to rank potential ligands, or by extension rank protein–ligand pairs, identifying potential drug candidates. Most docking methods use preferred sets of physicochemical descriptors (PCDs) to model the interactions between host and guest molecules. Thus, conventional VS is often data-specific, method-dependent and with demonstrably differing utility in identifying candidate drugs. This study proposes four universality classes of novel consensus scoring (CS) algorithms that combine docking scores, derived from ten docking programs (ADFR, DOCK, Gemdock, Ledock, PLANTS, PSOVina, QuickVina2, Smina, Autodock Vina and VinaXB), using decoys from the DUD-E repository (http://dude.docking.org/) against 29 MRSA-oriented targets to create a general VS formulation that can identify active ligands for any suitable protein target. Our results demonstrate that CS provides improved ligand–protein docking fidelity when compared to individual docking platforms. This approach requires only a small number of docking combinations and can serve as a viable and parsimonious alternative to more computationally expensive docking approaches. Predictions from our CS algorithm are compared against independent machine learning evaluations using the same docking data, complementing the CS outcomes. Our method is a reliable approach for identifying protein targets and high-affinity ligands that can be tested as high-probability candidates for drug repositioning.
Graphical Abstract
Exploring the Cross-cultural Applicability of a Brief Compassionate Mind Training: a Study Comparing Sri Lankan and UK People
Authors: Kariyawasam Lasara , Ononaiye Margarita , Irons Chris , Kirby Sarah E. 
Published: December 2022

Abstract
Objectives
Compassionate Mind Training (CMT) is a therapeutic approach proven to be effective for reducing distress and increasing well-being in clinical and non-clinical populations. This study aimed to explore the efficacy of a short-term, online version of the CMT on compassion, distress, and well-being in a cross-cultural, non-clinical sample of Sri Lankan and UK people.

Method
A randomized controlled trial with pre-, post-measurements, and a 2-week follow-up was conducted using CMT (n = 21 Sri Lankan, n = 73 UK) and wait-list control (n = 17 Sri Lankan, n = 54 UK) groups. The intervention effects were investigated using a series of repeated-measures ANOVAs using intention-to-treat and per-protocol analyses.

Results
The 2-week CMT was effective in increasing all aspects of compassion in both Sri Lankan and UK people. In addition, some cross-cultural similarities and differences (in the factors affecting compassion) were present in the improvements following CMT between the two countries, which were maintained at a 2-week follow-up.

Conclusion
This study provides promising evidence for the efficacy and cross-cultural applicability of CMT for reducing distress and increasing well-being.
Return to Reintegration? Towards a Circular-Economy-Inspired Management Paradigm
Authors: De Angelis Roberta , Peattie Ken 
Published: December 2022

AbstractHumanity has entered the Anthropocene, a new geological epoch marked by an unprecedented human impact upon planet Earth. In this context of “planetary emergency”, questioning the effectiveness of extant management research at guiding environmentally sustainable corporate outcomes has become more relevant than ever before. Responding to the calls for management scholars to reconceive the foundations of management research, this article draws on circular economy thinking to infuse the paradigmatic assumptions of the business and natural environment research field with the logic of ecological systems and bring them back to their early systemic orientation. It also discusses which barriers and limitations can prevent the circular economy from unleashing its transformational power.
Experimental characterization of thrust production mechanisms in a magnetic nozzle ECR thruster
Authors: Boni Federico , Désangles Victor , Jarrige Julien 
Published: December 2022

AbstractDirect thrust measurements have been performed on a low-power (30 W) ECR plasma thruster operated with xenon. The total thrust, the force exerted on the walls of the source (thermal thrust), and the force exerted on the permanent magnet (magnetic thrust) have been measured separately for various operating conditions (power and flowrate). The results are compared for two magnetic field topologies (with a different magnetic field gradient and divergence). The magnetic thrust dominates thermal thrust for most operating conditions, and its contribution to total thrust can be as high as 80%. A saturation of magnetic thrust with increasing power has been observed and is correlated with a decrease in thrust efficiency. A high degree of electron anisotropy can be inferred from the thrust measurements.
Admission temperature and neonatal outcomes - single-centre experience in Saudi Arabia
Authors: Fneish Ammar , Alhasoon Mohammad , Al Essa Amenah , Mahlangu Radha , Alshami Noura , Alsaif Saif , Ali Kamal 
Published: December 2022

Objective:
This study aimed to investigate the association between admission hypothermia (AH), neonatal mortality and major neonatal morbidities in preterm infants <33 weeks' gestation. An additional aim of the study was to examine changes in the prevalence of admission hypothermia after the initiation of a thermoregulation quality improvement (QI) project.

Method:
This is a retrospective cohort study of preterm infants < 33 weeks' gestation born at King AbdulAziz Medical City Riyadh (KAMC-R) between January 2017 to December 2020.

Results:
Eight-hundred infants were born during the study period. Four hundred and one infants (50.1%) had an admission temperature of <36.5 °C and a further 399 (49.9%) had an admission temperature of >36.5 °C. The mortality before discharge was 15.7% in infants with AH compared to 4.8% among those with an admission temperature above 36.5 °C. This remained statistically significant after adjustments for gestational age and maternal PET status on a multivariate analysis (P = .001, OR 2.7,95%CI 1.5–4.7). The need for mechanical ventilation (P = .005) and incidence of surgical NEC (P = .030) were significantly different between the two temperature groups. Mean (SD) admission temperature increased from 36.3 °C to 36.6 °C following the thermoregulation intervention program (P <.001). Admission temperature <36 °C is associated with higher mortality in the first week (P = .001, OR 3.3,95% CI (1.7–6.6)) and increased incidence of cystic PVL (P = .04, OR 2.1, CI (1.03–4.3)).

Conclusion:
Preterm infants with AH suffered higher mortality and greater neonatal morbidities.
COVID-19 and the Ugandan Presidential Election: Contesting Lockdown Authority in Popular Songs
Authors: Pier David G. , Mutagubya Micheal 
Published: December 2022

AbstractThe COVID-19 pandemic struck when Uganda was in the middle of an acrimonious campaign season, in which longstanding president Yoweri Museveni was being challenged by Bobi Wine, a reggae singer turned politician. When Museveni imposed a strict lockdown, musicians sympathetic to Wine responded with songs about COVID-19 that challenged the government’s short-term, biopolitical demarcation of the national emergency. Pier and Mutagubya interpret a selection of Ugandan COVID-19 pop songs from 2020, considering in musical-historical perspective their various strategies for re-narrating the health crisis.