bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atuação do assistente social frente a criança autista e sua família no centro de referência da assistência social em um município do interior do Maranhão
Authors: Silva Daniele Vilarindo , Sousa Ronny Batista de , Coelho Francisco das Chagas Araújo , Silva Viviane Soares , Cavalcante Neto Francisco de Souza , Soares Ionara da Silva , Santos Graciete Rodrigues dos 
Published: March 2023

O transtorno do espectro autista (TEA) é um transtorno que está intrinsecamente ligado ao neurodesenvolvimento da criança. o presente estudo teve como objetivo geral compreender a atuação do Assistente Social frente a pessoa com TEA, e objetivos específicos: apontar as leis e projetos direcionadas a pessoa com TEA; conhecer as especificidades do TEA e apontar a importância da família e do Serviço Social para a inclusão social da pessoa com TEA. Optou-se pela realização de uma pesquisa de campo e bibliográfica. Foi possível analisar, através de um questionário realizado com uma profissional da área, que o trabalho como assistente social é árduo e que constitui-se em um desafio para inserir, formar, desenvolver e gerar esperanças para as famílias. O papel da família para as pessoas com espectro deve se desenvolver de forma mais detalhada, pois o ritmo é diferente e sua integração ao meio social pode demorar, mas por outro lado deve haver ludicidade, intimidade e outros aspectos, principalmente no processo de atendimento ou reabilitação em instituições sociais.
Mémoire ontologique et mémoire spontanée : convergences et affrontements
Authors: Kohwer Rudy , Silva Edvania Gomes da 
Published: March 2023

Cet article a l’objectif d’interroger le rapport qu’ont les phénomènes de la perception immédiate d’avec ceux de la perception médiate, ceux plus centrés sur la mémoire et le passé. En faisant l’hypothèse de la mémoire spontanée dépendante de la mémoire ontologique, l’objet d’étude tient aux successions et aux qualités entre les simultanéités dans les états psychiques. Pour étudier cet objet, la réflexion initiale, sur les tenants de l’utilisation normale du langage dans l’axe chomskien, a attiré l’attention à propos du problème des qualités de chaque fait psychique se succédant. Pour retenir que le mode de raisonnement scientifique explicatif est pertinent en devant nécessairement être appuyé par l’expérience de la perception interne, les considérations théorico-méthodologiques sont en ce sens celles de Bergson (1889 ; 1965 ; 1968) sur la durée et celles de Brentano (2008 ; 2017) sur la perception interne. Les résultats de cette recherche contribueront à des règles qui mettent en relation, dans les énoncés linguistiques, les structures syntaxiques avec les représentations de signifié.
PRESERVATION OF UANG ASAP TRADITION IN MELAYU WEDDING: MAQĀSID SHAR'AH PERSPECTIVE
Authors: Humairah Siti 
Published: March 2023

This article is the result of a qualitative field research. This research is a legal sociology research. This article discusses determination of “Uang Asap” in the Malay wedding tradition. The researcher analyzed the research data using the maqasid shariah theory. The location of this research is in Nusapati Village, Sungai Pinyuh District, Mempawah Regency, West Kalimantan. The findings of this study are that in the view of maqasid sharia, the determination of smoked money is included in the category of tahsiniyat (tertiary) benefit. Field data shows that the giving of smoked money is a general tradition, in the sense that it applies to everyone of the Malay ethnicity, especially in Nusapati Village, Sungai Pinyuh District, Mempawah Regency, West Kalimantan. Although the giving of smoked money is not explicitly regulated in maqasid sharia, the giving of smoked money is already a tradition that must be carried out in the community and as long as this does not conflict with aqidah and shari'ah then it is allowed by Islamic law
Keywords: “uang asap” tradition, wedding traditions, maqasid shariah theory

Abstrak
Artikel ini adalah hasil penelitian kualitatif lapangan. Penelitian ini merupakan penelitian sosiologi hukum. Artikel ini mendiskusikan penetapan uang asap dalam tradisi pernikahan adat Melayu. Peneliti menganalisis data penelitian menggunakan teori maqasid shariah. Lokasi penelitian ini berada di Desa Nusapati Kecamatan Sungai Pinyuh Kabupaten Mempawah Kalimantan Barat. Temuan penelitian ini adalah bahwa Dalam pandangan maqasid syariah penetapan uang asap masuk dalam kategori kemaslahatan tahsiniyat (tersier). Data lapangan menunjukkan bahwa pemberian uang asap merupakan tradisi yang bersifat umum, dalam artian berlaku pada setiap orang yang bersuku Melayu khususnya di Desa Nusapati Kecamatan Sungai Pinyuh Kabupaten Mempawah Kalimantan Barat. Walaupun pemberian uang asap ini tidak secara gamblang diatur dalam maqasid syariah, namun pemberian uang asap sudah merupakan suatu tradisi yang harus dilakukan pada masyarakat tersebut dan selama hal ini tidak bertentangan dengan akidah dan syari’at maka hal itu diperbolehkan oleh hukum islam.

Kata Kunci: tradisi uang asap, adat pernikahan, teori maqasid shariah
LAW REASONING OF CHILD CUSTODIAL RIGHT FOR NON-MUSLIM MOTHER
Authors: Mashudi Ahmad Ali 
Published: March 2023

This article is result of library research. This research is included in the category of normative legal research. This research discussion aims to explain the legal status of non-Muslim mothers in the context of post-divorce child care. The findings of this study are that according to the ulama' of the four schools of thought, the haānah rights of an apostate mother should not be granted. The argument that is built is that haānah does not only take care of physically but also includes children's religious education. The non-Muslim mother is feared to have a direct or indirect influence on the child. The legal status of an apostate also affects legal action. The apostasy reduces the ability to raise children, so the majority of scholars' abort the haānah rights for apostate mothers. KHI explains child custody/haānah in general as regulated in article 105. Parenting rights of non-Muslim mothers are not regulated by KHI.
Keywords: Parenting rights, non-Muslim mothers, legal reasoning

Abstrak
Artikel ini adalah hasil dari penelitian pustaka (library research). Penelitian ini masuk dalam kategori penelitian hukum normatif. Diskusi penelitian ini bertujuan menjelaskan status hukum ibu nonmuslim dalam konteks pengasuhan anak pascaperceraian. Temuan penelitian ini adalah bahwa menurut ulama’ empat mazhab, hak haḍānah ibu murtad, tidak boleh diberikan. Argumen yang dibangun adalah haḍānah tidak hanya merawat secara jasmani saja akan tetapi haḍānah juga meliputi pendidikan agama anak. Ibu nonmuslim itu dikhawatirkan memberi pengaruh baik langsung maupun tidak langsung kepada anak. Status hukum seorang yang murtad juga mempengaruhi tindakan hukum. Kemurtadan itu mengurangi kecakapan dalam mengasuh anak, sehingga mayoritas ulama’ menggugurkan hak haḍānah bagi ibu murtad. KHI menjelaskan hak asuh anak/haḍānah secara umum saja sebagaimana diatur dalam pasal 105. Hak Pengasuhan ibu non muslim tidak diatur oleh KHI.
Kata kunci: Hak pengasuhan, ibu nonomuslim, nalar hukum
Osteoblast derived extracellular vesicles induced by dexamethasone: A novel biomimetic tool for enhancing osteogenesis in vitro
Authors: Zhang Xing , Zhao Qun , Zhou Nan , Liu Yu , Qin Kang , Buhl Eva Miriam , Wang Xinhong , Hildebrand Frank , Balmayor Elizabeth R. , Greven Johannes 
Published: March 2023

Extracellular vesicles (EVs) are newly appreciated communicators involved in intercellular crosstalk, and have emerged as a promising biomimetic tool for bone tissue regeneration, overcoming many of the limitations associated with cell-based therapies. However, the significance of osteoblast-derived extracellular vesicles on osteogenesis has not been fully established. In this present study, we aim to investigate the therapeutic potential of extracellular vesicles secreted from consecutive 14 days of dexamethasone-stimulated osteoblasts (OB-EVDex) to act as a biomimetic tool for regulating osteogenesis, and to elucidate the underlying mechanisms. OB-EVdex treated groups are compared to the clinically used osteo-inductor of BMP-2 as control. Our findings revealed that OB-EVDex have a typical bilayer membrane nanostructure of, with an average diameter of 178 ± 21 nm, and that fluorescently labeled OB-EVDex were engulfed by osteoblasts in a time-dependent manner. The proliferation, attachment, and viability capacities of OB-EVDex-treated osteoblasts were significantly improved when compared to untreated cells, with the highest proliferative rate observed in the OB-EVDex + BMP-2 group. Notably, combinations of OB-EVDex and BMP-2 markedly promoted osteogenic differentiation by positively upregulating osteogenesis-related gene expression levels of RUNX2, BGLAP, SPP1, SPARC, Col 1A1, and ALPL relative to BMP-2 or OB-EVDex treatment alone. Mineralization assays also showed greater pro-osteogenic potency after combined applications of OB-EVDex and BMP-2, as evidenced by a notable increase in mineralized nodules (calcium deposition) revealed by Alkaline Phosphatase (ALP), Alizarin Red Alizarin Red staining (ARS), and von Kossa staining. Therefore, our findings shed light on the potential of OB-EVDex as a new therapeutic option for enhancing osteogenesis.
Sinus node dysfunction and related permanent pacemaker implantation after major cardiac surgeries, systematic review, and meta-analysis
Authors: Hosseini Dolama Reza , Eghbal Amir Hosein , Rezaee Malihe , Farahani Ali Vasheghani , Jalali Arash , Hosseini Kaveh 
Published: March 2023

BackgroundThere is no concise evidence or clinical guidelines regarding the incidence of sinus node dysfunction (SND) and permanent pacemaker (PPM) implantation following cardiac surgeries and their management approaches.ObjectiveWe aim to systematically review current evidence on the prevalence of SND, PPM implantation concerning it, and its risk factors in patients undergoing cardiac surgery.MethodFour electronic databases (Cochrane Library, Medline, SCOPUS, and Web of Science) were systematically searched for articles regarding SND after cardiovascular surgeries and reviewed by two independent researchers, and a third review in case of discrepancies. Using the random-effects model, a proportion meta-analysis was performed on data regarding PPM implantation. Subgroup analysis was performed for different interventions, and the possible effect of different covariates was evaluated using meta-regression.ResultsFrom the initial 2012 unique records, 87 were included in the study, and results were extracted. Pooled data from 38,519 patients indicated that the overall prevalence of PPM implantation due to SND after cardiac surgery was 2.87% (95% CI [2.09; 3.76]). The incidence of PPM implantation in the first post-surgical month was 2.707% (95% CI [1.657; 3.952]). Among the four main intervention groups, including valve, maze, valve-maze, and combined surgeries, maze surgery was associated with the highest prevalence (4.93%; CI [3.24; 6.92]). The pooled prevalence of SND among studies was 13.71% (95% CI [8.13; 20.33]). No significant relationship was observed between PPM implantation and age, gender, cardiopulmonary bypass time, or aortic cross-clamp time.ConclusionBased on the present report, patients undergoing the maze and maze-valve procedures are at higher risk of post-op SND, whereas lone valve surgery had the lowest prevalence of PPM implantation.Systematic Review RegistrationPROSPERO (CRD42022341896).
Construction of a water resource suitability index for agricultural production and matching analysis of cultivated land in Lhasa, Tibet
Authors: Liu Yumei , Wang Zhiyong , Wang Chuansheng , Wang Yafei , Li Jiuyi , Liang Liqiao 
Published: March 2023

Water resources are essential for agriculture. In the spatial layout of agricultural production, quantitatively identifying the spatial differences in water resource conditions, including precipitation and irrigation water supply factors, is necessary. Here, a water resource suitability index for agricultural production (WRSIA) was constructed for agricultural development using irrigation water supply convenience (IWSC) and precipitation conditions. Considering Lhasa as the study area, water resource suitability index for agricultural production was calculated on a 100 m grid scale, and the spatial distribution relationship between water resource suitability index for agricultural production and cultivated land was analyzed using geographically weighted regression (GWR). The results showed that irrigation water supply convenience severely restricted agricultural production in Lhasa, and the high water resource suitability index for agricultural production values were mainly distributed in the valleys of the Lhasa River and its tributaries. Moreover, 47.7% of the cultivated land was distributed in 5% of the area having the highest water resource suitability. According to geographically weighted regression, the cultivated land area and water resource availability were strongly correlated (R2 = 0.904). The distribution of the cultivated land was well explained by water resource suitability index for agricultural production, which could describe the differences in water resource suitability for agricultural production. Furthermore, the suitability of agricultural production was better evaluated when water resource suitability index for agricultural production was coupled with the land resource suitability index. Overall, water resource suitability index for agricultural production showed high applicability in Lhasa and other regions, thereby providing a scientific basis and technical support for the spatial layout of agricultural production.
Development and validation of a genomic nomogram based on a ceRNA network for comprehensive analysis of obstructive sleep apnea
Authors: Liu Wang , Sun Xishi , Huang Jiewen , Zhang Jinjian , Liang Zhengshi , Zhu Jinru , Chen Tao , Zeng Yu , Peng Min , Li Xiongbin , Zeng Lijuan , Lei Wei , Cheng Junfen 
Published: March 2023

Objectives: Some ceRNA associated with lncRNA have been considered as possible diagnostic and therapeutic biomarkers for obstructive sleep apnea (OSA). We intend to identify the potential hub genes for the development of OSA, which will provide a foundation for the study of the molecular mechanism underlying OSA and for the diagnosis and treatment of OSA.Methods: We collected plasma samples from OSA patients and healthy controls for the detection of ceRNA using a chip. Based on the differential expression of lncRNA, we identified the target genes of miRNA that bind to lncRNAs. We then constructed lncRNA-related ceRNA networks, performed functional enrichment analysis and protein-protein interaction analysis, and performed internal and external validation of the expression levels of stable hub genes. Then, we conducted LASSO regression analysis on the stable hub genes, selected relatively significant genes to construct a simple and easy-to-use nomogram, validated the nomogram, and constructed the core ceRNA sub-network of key genes.Results: We successfully identified 282 DElncRNAs and 380 DEmRNAs through differential analysis, and we constructed an OSA-related ceRNA network consisting of 292 miRNA-lncRNAs and 41 miRNA-mRNAs. Through PPI and hub gene selection, we obtained 7 additional robust hub genes, CCND2, WT1, E2F2, IRF1, BAZ2A, LAMC1, and DAB2. Using LASSO regression analysis, we created a nomogram with four predictors (CCND2, WT1, E2F2, and IRF1), and its area under the curve (AUC) is 1. Finally, we constructed a core ceRNA sub-network composed of 74 miRNA-lncRNA and 7 miRNA-mRNA nodes.Conclusion: Our study provides a new foundation for elucidating the molecular mechanism of lncRNA in OSA and for diagnosing and treating OSA.
Circadian rhythm-related genes index: A predictor for HNSCC prognosis, immunotherapy efficacy, and chemosensitivity
Authors: Chi Hao , Yang Jinyan , Peng Gaoge , Zhang Jinhao , Song Guobin , Xie Xixi , Xia Zhijia , Liu Jinhui , Tian Gang 
Published: March 2023

BackgroundHead and neck squamous cell carcinoma (HNSCC) is the most common head and neck cancer and is highly aggressive and heterogeneous, leading to variable prognosis and immunotherapy outcomes. Circadian rhythm alterations in tumourigenesis are of equal importance to genetic factors and several biologic clock genes are considered to be prognostic biomarkers for various cancers. The aim of this study was to establish reliable markers based on biologic clock genes, thus providing a new perspective for assessing immunotherapy response and prognosis in patients with HNSCC.MethodsWe used 502 HNSCC samples and 44 normal samples from the TCGA-HNSCC dataset as the training set. 97 samples from GSE41613 were used as an external validation set. Prognostic characteristics of circadian rhythm-related genes (CRRGs) were established by Lasso, random forest and stepwise multifactorial Cox. Multivariate analysis revealed that CRRGs characteristics were independent predictors of HNSCC, with patients in the high-risk group having a worse prognosis than those in the low-risk group. The relevance of CRRGs to the immune microenvironment and immunotherapy was assessed by an integrated algorithm.Results6-CRRGs were considered to be strongly associated with HNSCC prognosis and a good predictor of HNSCC. The riskscore established by the 6-CRRG was found to be an independent prognostic factor for HNSCC in multifactorial analysis, with patients in the low-risk group having a higher overall survival (OS) than the high-risk group. Nomogram prediction maps constructed from clinical characteristics and riskscore had good prognostic power. Patients in the low-risk group had higher levels of immune infiltration and immune checkpoint expression and were more likely to benefit from immunotherapy.Conclusion6-CRRGs play a key predictive role for the prognosis of HNSCC patients and can guide physicians in selecting potential responders to prioritise immunotherapy, which could facilitate further research in precision immuno-oncology.
An experimental medicine decipher of a minimum correlate of cellular immunity: Study protocol for a double-blind randomized controlled trial
Authors: Kalimuddin Shirin , Chan Yvonne F. Z. , Sessions October M. , Chan Kuan Rong , Ong Eugenia Z. , Low Jenny G. , Bertoletti Antonio , Ooi Eng Eong 
Published: March 2023

Vaccination induces an adaptive immune response that protects against infectious diseases. A defined magnitude of adaptive immune response that correlates with protection from the disease of interest, or correlates of protection (CoP), is useful for guiding vaccine development. Despite mounting evidence for the protective role of cellular immunity against viral diseases, studies on CoP have almost exclusively focused on humoral immune responses. Moreover, although studies have measured cellular immunity following vaccination, no study has defined if a “threshold” of T cells, both in frequency and functionality, is needed to reduce infection burden. We will thus conduct a double-blind, randomized clinical trial in 56 healthy adult volunteers, using the licensed live-attenuated yellow fever (YF17D) and chimeric Japanese encephalitis-YF17D (JE-YF17D) vaccines. These vaccines share the entire non-structural and capsid proteome where the majority of the T cell epitopes reside. The neutralizing antibody epitopes, in contrast, are found on the structural proteins which are not shared between the two vaccines and are thus distinct from one another. Study participants will receive JE-YF17D vaccination followed by YF17D challenge, or YF17D vaccination followed by JE-YF17D challenge. A separate cohort of 14 healthy adults will receive the inactivated Japanese Encephalitis virus (JEV) vaccine followed by YF17D challenge that controls for the effect of cross-reactive flaviviral antibodies. We hypothesize that a strong T cell response induced by YF17D vaccination will reduce JE-YF17D RNAemia upon challenge, as compared to JE-YF17D vaccination followed by YF17D challenge. The expected gradient of YF17D-specific T cell abundance and functionality would also allow us to gain insight into a T cell threshold for controlling acute viral infections. The knowledge gleaned from this study could guide the assessment of cellular immunity and vaccine development.Clinical trial registrationClinicaltrials.gov, NCT05568953.
Enhancement of seaweed polysaccharides (fucoidan and laminarin) on the phagocytosis of macrophages via activation of intelectin in blunt snout bream (Megalobrama amblycephala)
Authors: Li Hongping , Liu Yunlong , Teng Yuting , Zheng Yancui , Zhang Minying , Wang Xu , Cheng Hanliang , Xu Jianhe , Chen Xiangning , Zhao Xiaoheng , Ding Zhujin 
Published: March 2023

Fucoidan and laminarin are polymolecular compounds that extracted from seaweed. As functional polysaccharides, they possess various biological functions such as immunomodulatory, anti-inflammatory, antiviral and antioxidant bioactivities. Fucoidan and laminarin modulate host immune responses by activating immune cells (macrophages, neutrophils, T lymphocytes) and inducing the expression of cytokines (TNFα, IL-1β, IL-6, IL-8, NF-κB). Intelectin is a novel lectin that plays important roles in bacterial agglutination and bactericidal effects by recognizing the polysaccharide components on the cell surface of pathogens, which can also enhance the phagocytosis of macrophages. The present study intends to explore the immunomodulatory effects of fucoidan, laminarin and intelectin on the macrophages of Megalobrama amblycephala. The results showed that the incubation of both fucoidan and laminarin at the concentration of 100 μg/mL for 4 h could enhance the phagocytic capacity of M. amblycephala macrophages, which also showed remodeled cytoskeleton with extended pseudopodia. In addition, fucoidan and laminarin could induce the expression of M. amblycephala intelectin (MaINTL) in the primary hepatocytes and macrophages, and the recombinant MaINTL (rMaINTL) could bind with fucoidan and laminarin. Furthermore, fucoidan and laminarin induced the expression of cytoskeletal remodeling related genes in the primary M. amblycephala macrophages, such as Rac1 and WASP, which should contribute to the enhancement of seaweed polysaccharides (fucoidan and laminarin) and MaINTL on the phagocytosis of M. amblycephala macrophages. However, even though fucoidan and laminarin could induced the expression of CXCL8, while the chemotaxis of M. amblycephala macrophages on neutrophils was not affected by them. These findings suggested that fucoidan and laminarin enhanced the phagocytic capacity of M. amblycephala macrophages via activation of MaINTL and up-regulation of the expression of downstream cytoskeletal remodeling related genes Rac1 and WASP. Therefore, fucoidan and laminarin could be used as immune enhancers to improve host immunity and disease resistance in M. amblycephala, which provided novel insights into the prevention and protection of fish bacterial diseases.