bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nationwide study of eculizumab in paroxysmal nocturnal hemoglobinuria: Evaluation of treatment indications and outcomes
Authors: Schaap Charlotte C. M. , Heubel‐Moenen Floor C. J. I. , Nur Erfan , Bartels Marije , van der Heijden Olivier W. H. , de Jonge Emiel , Preijers Frank W. M. B. , Blijlevens Nicole M. A. , Langemeijer Saskia M. C. ,   the Dutch PNH Working Group
Published: February 2023

AbstractEculizumab is an effective treatment for paroxysmal nocturnal hemoglobinuria (PNH). However, considering the risk of life‐threatening meningococcal disease, life‐long duration and costs, there are strict criteria for initiation of therapy. To evaluate the application and real‐world effectiveness of eculizumab in the Netherlands, a multicenter retrospective cohort study was conducted: indications and treatment outcomes were collected for 105 Dutch PNH patients. In all patients, eculizumab was initiated conforming to indications as formulated in the Dutch PNH guideline. According to recently published response criteria, 23.4% of the patients had reached a complete hematological response, 53.2% a good or partial response, and 23.4% a minor response after 12 months of therapy. In the majority of patients the response remained stable during long‐term follow‐up. The degree and relevance of extravascular hemolysis significantly differed between response groups (p = 0.002). Improvements of EORTC‐QLQc30 and FACIT‐fatigue scores were observed, however patients reported lower scores than the general population. A detailed evaluation of 18 pregnancies during eculizumab showed no maternal or fetal deaths, and no thromboembolic events during pregnancy. This study demonstrates that the majority of patients benefit from eculizumab when adhering to the indications as formulated in the Dutch PNH guideline. However, novel therapies are needed to further improve real‐world outcomes, such as hematological responses and quality of life.
Retention of passive integrated transponder tags in hatchery brook trout: Effect of tag size, implantation site, and double tagging
Authors: Peterson Douglas P. , Twibell Ronald G. , Piteo Matthew S. 
Published: February 2023

AbstractA fundamental assumption of mark‐recapture studies is that individuals do not lose their marks or tags, because tag loss can lead to biased parameter estimates. Retention of 8‐mm full‐duplex and 12‐mm half‐duplex passive integrated transponder (PIT) tags implanted in the abdomen, opercular musculature, and dorsal sinus of age‐0+ hatchery male brook trout (Salvelinus fontinalis) was evaluated in the laboratory. Treatments included single‐ and double‐tagged fish. Survival, growth, and tag retention were monitored for 181–187 days for 640 tagged fish and 80 untagged controls. Survival to 180 days ranged 95%–100% and was not affected by tagging. PIT‐tagging caused a short‐term reduction in growth rates. Tag retention to 180 days was 100% for dorsal implantation, 83.0% with 8‐mm tags in the operculum, 97.5% with 8‐mm tags in the abdomen, and 99.6% with 12‐mm tags in the abdomen. Retention of opercular tags was positively related to size at tagging. Tag loss was independent of whether fish were single‐ or double‐tagged. Double tagging with one full‐ and one half‐duplex PIT tag in different body locations would hedge against data loss relative to single tagging, especially for longer‐lived and iteroparous species where tag loss through time is more likely.
Steroid administration for ischemic complications after radiofrequency ablation: A retrospective study
Authors: Wake Taijiro , Tateishi Ryosuke , Moriyama Makoto , Fukumoto Tsuyoshi , Yamada Tomoharu , Nakagomi Ryo , Nakatsuka Takuma , Sato Masaya , Minami Tatsuya , Uchino Koji , Nakagawa Hayato , Shiina Shuichiro , Koike Kazuhiko , Fujishiro Mitsuhiro 
Published: February 2023

AbstractAimThe aim of this study was to evaluate the effects of steroids on ischemic complications after radiofrequency ablation.MethodsA total of 58 patients with ischemic complications were divided into two groups according to corticosteroid use or non‐use.ResultsA total of 13 patients who were administered steroids had a shorter duration of fever than those who were not administered steroids (median 6.0 vs. 2.0 days; p < 0.001). Linear regression analysis showed that steroid administration was associated with a reduction of 3.9 days in the duration of fever (p = 0.008).ConclusionsSteroid administration for ischemic complications after radiofrequency ablation may reduce the risk of fatal outcomes by blocking systemic inflammatory reactions.
Seasonal variability in body mass index change among children enrolled in the Pediatric Obesity Weight Evaluation Registry: A step in the right direction
Authors: Lane Taylor S. , Sonderegger Derek L. , Binns Helen J. , Kirk Shelley , Christison Amy L. , Novick Marsha , Tucker Jared , King Eileen , Wallace Stephenie , Brazendale Keith , Kharofa Roohi Y. , Walka Sherry , Heer Hendrik ‘Dirk’ De ,   the POWER Work Group
Published: February 2023

SummaryBackgroundResearch has shown children disproportionately gain excess weight over the summer months (vs. school months), with stronger effects for children with obesity. However, the question has not been investigated among children receiving care in paediatric weight management (PWM) programs.ObjectiveTo test for seasonal variability in weight change among youth with obesity in PWM care enrolled in the Pediatric Obesity Weight Evaluation Registry (POWER).MethodLongitudinal evaluation of a prospective cohort from 2014 to 2019 among youth in 31 PWM programs. Change in percentage of the 95th percentile for BMI (%BMIp95) was compared by quarter.ResultsParticipants (N = 6816) were primarily ages 6–11 (48%), female (54%), 40% non‐Hispanic White, 26% Hispanic and 17% Black, and 73% had severe obesity. Children were enrolled on average 424.9 ± 401.5 days. Participants reduced their %BMIp95 every season, but compared with Quarter 3 (July–September), reductions were significantly greater in Q1 (Jan‐March, b = −0.27, 95%CI −0.46, −0.09), Q2 (April–June, b = −0.21, CI −0.40, −0.03), and Q4 (October–December, b = −0.44, CI −0.63, −0.26).Conclusion and RelevanceAcross 31 clinics nationwide, children reduced their %BMIp95 every season, but reductions were significantly smaller during the summer quarter. While PWM successfully mitigated excess weight gain during every period, summer remains a high‐priority time.
Patient admission scheduling problems with uncertain length of stay: optimization models and an efficient matheuristic approach
Authors: Guido Rosita 
Published: February 2023

AbstractIn this paper, we study two well‐known problems that are attracting increasing attention in the last years: patient admission and patient‐to‐room assignment problems. These two problems are often complicated by some patients, which may have fluctuations in length of stay (LOS). We propose an optimization model that plans patient admissions and patient stays considering fluctuations in LOS and does not allow overcrowded rooms, as typically required in real‐world cases. We develop an efficient matheuristic approach based on large neighborhood search and fix and optimize heuristic. We tested our optimization model and some variations of the objective function on benchmark instances from the literature. The computational results indicate the effectiveness of the proposed methods in improving the quality of care offered to the patients. Furthermore, the proposed approach can provide a useful support to decision makers for patient flow management and avoid disruptions in access to care due to bed shortages.
Can triage nurses accurately interpret the electrocardiogram in the emergency department to predict acute cardiovascular events? A prospective observational study
Authors: Sibilio Serena , Zaboli Arian , Magnarelli Gabriele , Canelles Massimiliano Fanni , Rella Eleonora , Pfeifer Norbert , Brigo Francesco , Turcato Gianni 
Published: February 2023

AbstractAimsThe prompt recording of the electrocardiogram (ECG) and its correct interpretation is crucial to the management of patients who present to the emergency department (ED) with cardiovascular symptoms. Since triage nurses represent the first healthcare professionals evaluating the patient, improving their ability in interpreting the ECG could have a positive impact on clinical management. This real‐world study investigates whether triage nurses can accurately interpret the ECG in patients presenting with cardiovascular symptoms.DesignProspective, single‐centre observational study conducted in a general ED of General Hospital of Merano in Italy.MethodsFor all patients included, the triage nurses and the emergency physicians were asked to independently interpret and classify the ECGs answering to dichotomous questions. We correlated the interpretation of the ECG made by the triage nurses with the occurrence of acute cardiovascular events. The inter‐rater agreement in ECG interpretation between physicians and triage nurses was evaluated with Cohen's kappa analysis.ResultsFour hundred and ninety‐one patients were included. The inter‐rater agreement between triage nurses and physicians in classifying an ECG as abnormal was good. Patients who developed an acute cardiovascular event were 10.6% (52/491), and in 84.6% (44/52) of them, the nurse accurately classified the ECG as abnormal, with a sensitivity of 84.6% and a specificity of 43.5%.ConclusionTriage nurses have a moderate ability in identifying alterations in specific components of the ECG but a good ability in identifying patterns indicative of time‐dependent conditions correlated with major acute cardiovascular events.Impact for NursingTriage nurses can accurately interpret the ECG in the ED to identify patients at high risk of acute cardiovascular events.Reporting MethodThe study was reported according to the STROBE guidelines.No Patient or Public ContributionThe study did not involve any patients during its conduction.
Exploring the emergence of waste recovery and exchange in industrial clusters
Authors: Noori Shiva , Korevaar Gijsbert , Stikkelman Rob , Ramírez Andrea 
Published: February 2023

AbstractSelf‐organized industrial symbiosis (IS) starts with one actor's decision to invest in a waste recovery plant and the other actors' decision to buy the recovered flow. Technical and institutional conditions of the cluster influence actors' decisions. This paper explores the emergence of IS collaborations in industrial clusters under different techno‐economic conditions in the long term. We propose a mixed‐integer linear programming model that incorporates costs and constraints associated with waste recovery and exchange to study actors' investment decisions and investigate shaped symbiotic exchanges under rising energy prices and limited electricity supply. The approach is implemented in Iran's Persian Gulf Mining and Metals Special Economic Zone as a case study. The results revealed that changes in internal or external condition simultaneously influence the industrial and waste recovery plants. For instance, increasing energy prices without raising product prices significantly decreased the production level of industrial plants and, consequently, heat recovery potential. Furthermore, the waste heat recovery plants' contribution to improving the cluster's economic and environmental performance was not the same. Electricity recovery from a power plant's waste heat can result in 55 PJ grid electricity intake reduction and 720 M€ cluster cash flow increase. Recovered cooling or electricity from the steelmaking plant waste heat was consumed internally rather than shaping IS. These model outcomes show its capability to study IS within the socio‐technical structure of the cluster, not a standalone phenomenon. Implemented conceptualization offers a novel system‐level approach, which could be adjusted to assess other industrial development strategies.
Interventions to Reduce Inpatient and Discharge Opioid Prescribing for Postpartum Patients: A Systematic Review
Authors: Badreldin Nevert , Ditosto Julia D. , Holder Kai , Beestrum Molly , Yee Lynn M. 
Published: February 2023

IntroductionAs deaths related to opioids continue to rise, reducing opioid use for postpartum pain management is an important priority. Thus, we conducted a systematic review of postpartum interventions aimed at reducing opioid use following birth.MethodsFrom database inception through September 1, 2021, we conducted a systematic search in Embase, MEDLINE, Cochrane Library, and Scopus including the following Medical Subject Heading (MeSH) terms: postpartum, pain management, opioid prescribing. Studies published in English, restricted to the United States, and evaluating interventions initiated following birth with outcomes including an assessment of change in opioid prescribing or use during the postpartum period (<8 weeks postpartum) were included. Authors independently screened abstracts and full articles for inclusion, extracted data, and assessed study quality using the Grading of Recommendations, Assessment, Development, and Evaluation tool and risk of bias using the Institutes of Health Quality Assessment Tools.ResultsA total of 24 studies met inclusion criteria. Sixteen studies evaluated interventions aimed at reducing postpartum opioid use during the inpatient hospitalization, and 10 studies evaluated interventions aimed at reducing opioid prescribing at postpartum discharge. Inpatient interventions included changes to standard order sets and protocols for the management of pain after cesarean birth. Such interventions resulted in significant decreases in inpatient postpartum opioid use in all but one study. Additional inpatient interventions, including use of lidocaine patches, postoperative abdominal binder, valdecoxib, and acupuncture were not found to be effective in reducing postpartum opioid use during inpatient hospitalization. Interventions targeting the postpartum period included individualized prescribing and state legislative changes limiting the duration of opioid prescribing for acute pain both resulted in decreased opioid prescribing or opioid use.DiscussionA variety of interventions aimed at reducing opioid use following birth have shown efficacy. Although it is not known if any single intervention is most effective, these data suggest that implementation of any number of interventions may be advantageous in reducing postpartum opioid use.
Evaluation of the trueness and precision of conventional impressions versus digital scans for the all‐on‐four treatment in the maxillary arch: An in vitro study
Authors: Marshaha Nour Jamal , Azhari Amr Ahmed , Assery Mansour K , Ahmed Walaa Magdy 
Published: February 2023

AbstractPurposeTo compare the accuracy of digitizing conventional impressions to intraoral surface scans for all‐on‐four treatment in the maxillary arch.Materials and methodsAn edentulous maxillary arch model with four implants placed in an all‐on‐four design was fabricated. Intraoral surface scans (n = 10) were obtained using an intraoral scanner after scan body insertion. For conventional polyvinylsiloxane impressions of the model, implant copings were inserted into the implant fixation for implant level, opened tray impressions (n = 10). The model and conventional impressions were digitized to obtain digital files. A reference file was created using a laboratory‐scanned conventional standard tessellation language (STL) file with analog to scan the body using exocad software. STL datasets from the two digital and conventional impression groups were superimposed with reference files to assess the 3D deviations. Two‐way ANOVA and paired‐samples t‐test was performed to assess the difference in trueness and examine the effects of impression technique and implant angulation on the deviation amount.ResultsNo significant differences were found between the conventional impression and intraoral surface scan groups F(1, 76) = 2.705, p = 0.104. No significant differences were found between conventional straight and digital straight implants and between conventional and digital tilted implants F(1, 76) = .041, p = 0.841. No significant differences were found between conventional straight and conventional tilted implants p = 0.07 and between digital straight and digital tilted implants p = 0.08.ConclusionDigital scans were more accurate than conventional impressions. The digital straight implants were more accurate than the conventional straight implants, and the digital tilted implants were more accurate than the conventional tilted implants, with higher accuracy for digital straight implants.
Effects of School Policies and Programs on Violence Among All High School Students and Sexual and Gender Minority Students
Authors: Cruz Theresa H. , Ross‐Reed Danielle E. , FitzGerald Courtney A. , Overton Kathryn , Landrau‐Cribbs Erica , Schiff Melissa 
Published: February 2023

ABSTRACTBACKGROUNDYouth identifying as lesbian, gay, bisexual (LGB) and/or transgender/gender nonconforming (TGNC) are at increased risk of violence. School policies and practices may mitigate this risk.METHODSResearchers merged data from the 2016 New Mexico School Health Profiles and the 2017 New Mexico Youth Risk and Resiliency Survey. Researchers employed multivariable logistic regression to test the associations between school‐level measures and violence outcomes.RESULTSGenders and sexualities alliances (GSAs) were associated with reduced odds of lifetime forced sex among all, heterosexual cisgender, and LGB students, reduced odds of sexual violence among heterosexual cisgender students, and reduced odds of dating violence among LGB students. Inclusive sexual health education was associated with reduced odds of lifetime forced sex among LGB and TGNC students, reduced odds of sexual violence among LGB students, and increased odds of dating violence among heterosexual cisgender students. Inclusive teacher training was associated with increased odds of lifetime forced sex among TGNC students.IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE, AND EQUITYInclusive sexual health education and the presence of active GSAs may have the greatest potential for reducing violence, especially among LGB and TGNC students.CONCLUSIONSFindings highlight the important role of school policies and practices in addressing violence.
Natural occurrence of cucumber mosaic virus infecting Physalis peruviana plants in Brazil
Authors: Bello Vinicius Henrique , Carpim Larissa , Lorenzi Harri José , Rezende Jorge Alberto Marques , Kitajima Elliot Watanabe 
Published: February 2023

AbstractIn 2020, virus‐like symptoms such as leaf size reduction, mosaic, and blistering were observed in Physalis peruviana plants in Brazil. Isometric particles ca. 30 nm in diameter were observed by transmission electron microscope in leaf extracts of field‐symptomatic plants. Based on molecular assays and nucleotide sequencing of amplicons, cucumber mosaic virus (CMV, genus Cucumovirus) was identified in mixed infection with physalis rugose mosaic virus (PhyRMV, genus Sobemovirus). Phylogenetic analysis indicated that the CMV belongs to the subgroup IA. Symptoms like those of field symptomatic plants were observed on mechanically inoculated plants of P. peruviana. RT‐PCR confirmed CMV and PhyRMV infection. CMV was transmitted by Aphis gossypii to P. peruviana plants. This is the first report of CMV infecting P. peruviana plants in Brazil.
Affective Priming Effects by Task‐Relevant and Task‐Irrelevant Emotional Pictures: An ERP Study
Authors: Zhu Anqi , Takeda Yuji 
Published: February 2023

AbstractThe present study examined how task‐relevant and task‐irrelevant prime stimuli influence the affective priming effect. An emotional picture (unpleasant or neutral) and a checkerboard picture were presented simultaneously as a prime stimulus. Participants were required to pay attention to either the emotional picture (EP‐attended condition) or the checkerboard picture (CP‐attended condition). An emotionally neutral picture (target) was then presented, and participants were asked to evaluate the emotional valence of the target. The evaluation score was more negative following the unpleasant prime picture, and this priming effect was larger in the EP‐attended condition, in which the emotional prime picture was task‐relevant than in the CP‐attended condition, in which the emotional prime picture was task‐irrelevant. The late positive potentials (LPPs) elicited by the prime stimuli were larger when the emotional prime picture was unpleasant, whereas the LPPs elicited by the target stimuli were smaller when the emotional prime picture was unpleasant. More importantly, significant association between the LPP amplitudes and the magnitude of affective priming effects were observed in the EP‐attended condition but not in the CP‐attended condition. This indicates that the degree of the affective priming effect induced by the task‐relevant prime stimulus was related to attentional resource allocation, but this was not the case for the affective priming effect induced by the task‐irrelevant prime stimulus. The present results suggest that affective priming effects induced by task‐relevant and task‐irrelevant prime stimuli occur in a different manner in terms of attentional processing.
Declining Quantity and Quality of Births in Chile amidst the COVID‐19 Pandemic
Authors: Pesando Luca Maria , Abufhele Alejandra 
Published: February 2023

AbstractExtensive demographic scholarship shows that the population‐level implications of mortality crises such as the COVID‐19 pandemic extend beyond mortality dynamics to affect fertility and family‐formation strategies. Using novel municipality‐level data from Chile covering all births that occurred between January 2017 and December 2021, this study explores trends in fertility and implications of the COVID‐19 pandemic for “quantum” and “quality” of births in the Chilean context. Building both a monthly and a yearly panel of 346 municipalities and leveraging fixed‐effects regression analyses, we focus on births and crude birth rates to measure quantum, while quality is assessed through the share of births that are low‐weight (LBW) and preterm (PTB). Our findings provide evidence of a significant drop in fertility in the wake of COVID—of the magnitude of a reduction of 1.3 live births per 1,000 individuals—which reaches a minimum around February 2021, followed by an incipient rebound in late 2021. Moreover, estimates on child health at birth suggest that the COVID period was associated with an increase in LBW and, foremost, PTB, by 1 and 2.2 percentage points, respectively. Findings from this study shed light on the role of policy interventions in the health arena and the linkages between short‐ and long‐run effects in relation to the various COVID‐19 waves in Chile.