bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quasars as high‐redshift standard candles
Authors: Risaliti G. , Lusso E. , Nardini E. , Bargiacchi G. , Bisogni S. , Sacchi A. , Signorini M. , Trefoloni B. 
Published: April 2023

AbstractIn the past few years, we built a Hubble diagram of quasars up to redshift , based on the nonlinear relation between quasars' x‐ray and UV luminosities. Such a Hubble diagram shows a deviation from the standard flat CDM model at . Given the important consequences of this result, it is fundamental to rule out any systematic effect in the selection of the sample and/or in the flux measurements, and to investigate possible redshift dependences of the relation, that would invalidate the use of quasars as standard candles. Here we review all the observational results supporting our method: the match of the Hubble diagram of quasars with that of supernovae in the common redshift range, the constant slope of the relation at all redshifts, the redshift non‐evolution of the spectral properties of our sources both in the x‐rays and in the UV. An independent test of our results requires the observation of other standard candles at high redshift. In particular, we expect that future observations of supernovas at will confirm the deviation from the concordance model found with the Hubble diagram of quasars.
Untersuchung von Dunstabzugssystemen in Wohnküchen
Authors: Bräunlich Kristin , Bruns Alfred , Hartmann Thomas , Broege Martina , Schwede Steffen , Kaufmann Berthold , Rüschen Kai , Zönnchen Enrico 
Published: April 2023

AbstractAngesichts der aktuellen Ereignisse wird einmal mehr bewusst, dass Energieeffizienz und damit die Reduktion des Energiebedarfs der Schlüssel zur dauerhaften Unabhängigkeit von fossilen Energieträgern ist. Energieeffizienz am Gebäude beginnt dabei schon bei den einzelnen Komponenten. In einem aktuellen Forschungsvorhaben zu Dunstabzugssystemen in Wohnküchen konnten wesentliche Einsparpotenziale für diesen Bereich noch einmal beleuchtet werden.Der Energieverbrauch von Abluftdunstabzugssystemen ergibt sich im Wesentlichen aus der Summe der Lüftungswärmeverluste durch den Abluftvolumenstrom (insbesondere ohne Wärmerückgewinnung) während des Kochvorgangs bzw. der Betriebszeit der Dunstabzugshaube und den Infiltrationsverlusten durch undichte Abluftklappen sowie Wärmebrückeneffekte, welche vor allem außerhalb der Betriebszeit wirksam sind.Leckagemessungen an Abluftklappen (Mauerkästen) zeigten auf, wie hoch die Infiltration und damit der dauerhafte Luftaustausch bei marktüblichen Systemen tatsächlich sind. Außerdem wurden Versuche zur Ermittlung der Wrasenerfassung durchgeführt. Mit einem standardisierten Verfahren zur Ermittlung der Wrasenerfassung ließe sich die tatsächliche energetische Performance der Dunstabzugssysteme aufzeigen und damit die Kaufentscheidung der Endkunden hin zu effizienteren und geeigneteren Lösungen lenken.
Structure, function, and evolution of the metal‐binding domain in the nucleosome
Authors: Saavedra Raul A. 
Published: April 2023

AbstractThe eukaryotic nucleosome, the basic unit of chromatin, is thermodynamically stable and plays critical roles in the cell, including the maintenance of DNA topology and regulation of gene expression. At its C2 axis of symmetry, the nucleosome exhibits a domain that can coordinate divalent metal ions. This article discusses the roles of the metal‐binding domain in the nucleosome structure, function, and evolution.
Symptomatic benefit of momelotinib in patients with myelofibrosis: Results from the SIMPLIFY phase III studies
Authors: Mesa Ruben A. , Hudgens Stacie , Floden Lysbeth , Harrison Claire N. , Palmer Jeanne , Gupta Vikas , McLornan Donal P. , McMullin Mary F. , Kiladjian Jean‐Jaques , Foltz Lynda , Platzbecker Uwe , Fox M. Laura , Mead Adam J. , Ross David M. , Oh Stephen T. , Perkins Andrew , Leahy Michael F. , Deheshi Samineh , Donahue Rafe , Klencke Barbara J. , Verstovsek Srdan 
Published: April 2023

AbstractBackgroundMyelofibrosis (MF)‐associated constitutional symptoms can severely impact health‐related quality of life. Clinical trials in MF traditionally measure symptom response to treatment as a landmark endpoint of total symptom score (TSS) reduction ≥50% from baseline. However, this dichotomous assessment provides a limited view of clinically relevant symptomatic changes. Herein we evaluated longitudinal change from baseline in TSS over the continuous 24‐week period and individual symptom scores to obtain a more comprehensive understanding of symptom benefits experienced by patients with MF receiving therapy.MethodsLongitudinal symptom change was evaluated using mixed‐effect model repeated measure (MMRM) methodology with individual item‐level analyses to complement the interpretation of the landmark symptom results in the completed phase III SIMPLIFY studies of momelotinib in MF. MMRM compared mean change in TSS from baseline with Week 24 using data from all patient visits. Generalized estimating equations were used to estimate item‐level odds ratios using multiple predictive imputations for missing data.ResultsMomelotinib and ruxolitinib groups reported similar overall symptom improvements, with a TSS difference of <1.5 points between groups for each post‐baseline visit in SIMPLIFY‐1. In SIMPLIFY‐2, the improvement in TSS observed in momelotinib‐treated patients was consistent with that observed in SIMPLIFY‐1, whereas progressive TSS deterioration was observed with control. Item‐level scores were heterogeneous in both studies. A similar and greater proportion of momelotinib‐treated patients were categorized as “improved” or “stable” compared with control in SIMPLIFY‐1 and SIMPLIFY‐2, respectively. Odds ratios for between‐group comparison ranged from 0.75 to 1.21 in SIMPLIFY‐1, demonstrating similarity in likelihood of symptom improvement. In SIMPLIFY‐2, the likelihood of symptom improvement in each item was higher in the momelotinib arm.ConclusionsThese findings suggest that momelotinib provides clinically relevant symptom benefits in the JAK inhibitor‐naïve and JAK inhibitor‐exposed settings.
Phytochemical Compounds of Euphorbia bivonae Extract and Their Cytotoxicity Effects on the Lethality of Brine Shrimp Artemia salina and Embryonic Kidney (HEK293) Cells
Authors: Enneb Hanen , Athmouni Khaled , Thabet Rahma , Ayadi Habib 
Published: April 2023

AbstractIn this research article, we investigated the effect of Euphorbia bivonae extract compounds on the lethality of brine shrimp Artemia salina and on embryonic cell lines (HEK293) proliferation. Our GC/MS analysis revealed that the E. bivonae ethanolic extract contained essentially sitosterol, euphol, and lupeol. The 24‐h LC50 was determined using the probit analysis method (LC50=357.11 mg l−1). Depending on this cytotoxicity test result, E. bivona extract induced a significant increase in Superoxide Dismutase (SOD), Catalase (CAT), Glutathione‐Peroxidase (GPx) activities, and lipid peroxidation (LPO) in A. salina larvae. In addition, the cytotoxicity effect of this extract had proved against the HEK293 cell lines in vitro. We suggest that the three compounds of E. bivonae extract (sitosterol, euphol, and lupeol) are the most responsible for this cytotoxicity. The possible application of this extract as an alternative natural antiproliferative is considered.
EDTA‐induced pseudothrombocytopenia in hematopoietic stem cell donor
Authors: Tsubokura Misato , Kojima Minoru , Nakabayashi Saori , Takahashi Noriko , Takeuchi Sayaka , Aruga Yu , Ikeda Chiaki , Maezawa Naoki , Okazaki Koji , Uchida Sanshiro , Watanabe Mizuki , Aoki Jun , Ito Ayumu , Tanaka Takashi , Inamoto Yoshihiro , Kim Sung‐Won , Matsushita Hiromichi , Fukuda Takahiro 
Published: April 2023

AbstractWe herein report a case of peripheral blood stem cell transplantation (PBSCT) involving a donor with EDTA‐induced pseudothrombocytopenia (PTCP). The apheresis product was inspected for 24 h and there was no platelet clumping or thrombocytopenia. In the first 14 months after PBSCT, there has been no transfer of PTCP symptoms.
Enantioselective Sequential Catalytic Arylation‐Fukuyama Cross‐coupling of 1,1‐Biszincioalkane Linchpins
Authors: Banchini Federico , Leroux Baptiste , Le Gall Erwan , Presset Marc , Jackowski Olivier , Chemla Fabrice , Perez‐Luna Alejandro 
Published: April 2023

Abstract1,1‐Bis(iodozincio)alkanes are used as dinucleophilic linchpins in an enantioselective double cross‐coupling reaction sequence involving aryl iodides and then thioesters. The two catalytic C−C bond‐forming reactions are achieved in the same pot through two distinct palladium‐based catalytic systems: a first non‐enantioselective one delivering configurationally labile secondary benzylzinc species from an achiral precursor, and a second enantioconvergent one that operates a highly efficient dynamic kinetic resolution of the racemic intermediates. This strategy, new in the area of asymmetric synthesis through two consecutive electrophilic substitution reactions of geminated C(sp3)‐organodimetallics, provides useful methodology to access in a modular fashion acyclic α‐disubstituted ketone products with very high enantiomeric purity.
Formal [2+1] Cycloadditions of a Metallacyclopentadiene Unit with Alkynes: Constructing Tetracyclic Conjugated Frameworks with Bridgehead Metals
Authors: Chu Zhenwei , Li Jinhua , Chen Dafa , Lu Zhengyu , Meng Weiran , Luo Ming , Xia Haiping 
Published: April 2023

Comprehensive SummaryMetallacyclopentadienes play a vital role in transition‐metal mediated and catalyzed cycloaddition reactions of alkynes. Though versatile reactions of metallacyclopentadienes with alkynes have been disclosed, [2+1] cycloadditions of metallacyclopentadienes and alkynes have never been discovered. In present work, we report the formal [2+1] cycloadditions of a metallacyclopentadiene unit with a broad scope of commercial alkynes, providing a facile strategy to construct tetracyclic conjugated compounds. The deuterated experiment indicates a metal vinylidene intermediate has been involved in [2+1] cycloaddition. Moreover, the electrophilic substitution reaction of the tetracyclic conjugated compound with the aid of density functional theory (DFT) calculated Fukui functions is investigated. These tetracyclic conjugated compounds exhibit broad absorption spectra in the whole visible region which could be employed as potential photovoltaic materials.
A verified and validated moving domain computational fluid dynamics solver with applications to cardiovascular flows
Authors: Kjeldsberg Henrik A. , Sundnes Joakim , Valen‐Sendstad Kristian 
Published: April 2023

AbstractComputational fluid dynamics (CFD) in combination with patient‐specific medical images has been used to correlate flow phenotypes with disease initiation, progression and outcome, in search of a prospective clinical tool. A large number of CFD software packages are available, but are typically based on rigid domains and low‐order finite volume methods, and are often implemented in massive low‐level C++ libraries. Furthermore, only a handful of solvers have been appropriately verified and validated for their intended use. Our goal was to develop, verify and validate an open‐source CFD solver for moving domains, with applications to cardiovascular flows. The solver is an extension of the CFD solver Oasis, which is based on the finite element method and implemented using the FEniCS open source framework. The new solver, named OasisMove, extends Oasis by expressing the Navier–Stokes equations in the arbitrary Lagrangian–Eulerian formulation, which is suitable for handling moving domains. For code verification we used the method of manufactured solutions for a moving 2D vortex problem, and for validation we compared our results against existing high‐resolution simulations and laboratory experiments for two moving domain problems of varying complexity. Verification results showed that the error followed the theoretical convergence rates. The temporal accuracy was second‐order, while the spatial accuracy was second‐ and third‐order using and finite elements, respectively. Validation results showed good agreement with existing benchmark results, by reproducing lift and drag coefficients with less than 1% error, and demonstrating the solver's ability to capture vortex patterns in transitional and turbulent‐like flow regimes. In conclusion, we have shown that OasisMove is an open‐source, accurate and reliable solver for cardiovascular flows in moving domains.
Anomalous Inferior Zn Anode in High‐Concentration Electrolyte: Leveraging Solid‐Electrolyte‐Interface for Stabilized Cycling of Aqueous Zn‐Metal Batteries
Authors: Guo Yalan , Li Zhengang , Min Yulin , Wang Xin 
Published: April 2023

AbstractAqueous Zn‐metal batteries (AZMBs) are promising large‐scale energy storage devices for their high safety and theoretical capacity. However, unstable Zn‐electrolyte interface and severe side reactions have excluded AZMBs from long cycling required by practically reversible energy storage. Traditional high‐concentration electrolyte is an effective strategy to suppress dendrites growth and resolve the poor electrochemical stability and reversibility of Zn‐metal anodes, yet how scientifically universal such strategy is for hybrid electrolyte of different concentrations remains unclear. Herein, we studied the electrochemical behaviors of AZMBs comprising a ZnCl2‐based DMSO/H2O electrolyte of two distinct concentrations (1 m vs. 7 m). The electrochemical stability/reversibility of Zn anodes in both symmetric and asymmetric cells with high‐concentration electrolytes are unusually inferior to the ones with low‐concentration electrolyte. It was found that more DMSO components in the solvation sheath of low‐concentration electrolyte exist at the Zn‐electrolyte interface than in high‐concentration counterpart, enabling higher organic compositions in solid‐electrolyte‐interface (SEI). The rigid inorganic and flexible organic compositions of SEI decomposed from the low‐concentration electrolyte is accounted for improved cycling and reversibility of Zn metal anodes and the respective batteries. This work reveals the critical role of SEI than the high concentration itself in delivering stable electrochemical cycling in AZMBs.
The effects of exposure to physical and emotional violence from partners on psychological resilience, forgiveness, happiness, life satisfaction, and depression level in Turkish women
Authors: Dikmen Hacer Alan , Çankaya Seyhan 
Published: April 2023

AbstractThe data of this descriptive and correlational study were collected from 583 women between October 2021 and December 2021 with information form, Brief Resilience Scale, Oxford Happiness Scale—Short Form, Epidemiological Research Center Depression Scale, Heartland Forgiveness Scale, and Life Satisfaction Scale. There is a statistically significant difference between the resilience, happiness, and life satisfaction levels of women exposed to physical violence from their partners and the presence of depression (p < .001). A statistically significant difference was found between the presence of depression and resilience, happiness, and life satisfaction (p < .001) and forgiveness (p = .004) in women who were exposed to emotional violence from their partners. While resilience, happiness, and life satisfaction levels decreased in women who were exposed to physical violence from their partners, the incidence of depression increased. While the presence of depression increased in women who were exposed to emotional violence from their partners, the level of resilience, happiness, life satisfaction, and forgiveness decreased.
Data‐driven predictions of summertime visits to lakes across 17 US states
Authors: Nelson Erik , Rogers Maggie , Wood Spencer A. , Chung Jesse , Keeler Bonnie 
Published: April 2023

AbstractUsing a dataset of more than 51,000 US lakes, we estimated the relationship between summertime lake visits, lake water clarity, landscape features, and other amenities, where visits were estimated with counts of geo‐located photographs. Given the size and complexity of our dataset, we used a combination of machine learning techniques, imputation techniques, and a Poisson count model to estimate these relationships. We found that every additional meter of average summertime Secchi depth was associated with at least 7% more summertime lake visits, all else equal. Second, we found that lake amenities, such as beaches, boat launches, and public toilets, were more powerful predictors of visits than water clarity. Third, we found that visits to a lake were strongly influenced by the lake's accessibility and its distance to nearby lakes and the amenities the nearby lakes offered. Our research highlights the need for (1) a better understanding of how representative social media data are of actual recreational behavior, (2) the development of best practices to account for nonrandom patterns in missing natural feature data, and (3) a better understanding of the potential endogeneity in the lake visit–water quality relationships.
Value of troponin T versus I in the diagnosis of immune checkpoint inhibitor‐related myocarditis and myositis: rechallenge?
Authors: Rossi Valentina A. , Gawinecka Joanna , Dimitriou Florentia , von Eckardstein Arnold , Dummer Reinhard , Ruschitzka Frank , Matter Christian M. 
Published: April 2023

AbstractA 54‐year old patient with metastatic melanoma presented with asymptomatic myositis and myocarditis after combined immune checkpoint inhibitors (ICI) therapy (anti‐programmed cell death receptor‐1, anti‐lymphocyte activating gene‐3, and anti‐indoleamine 2,3‐dioxygenase‐1). The diagnosis was based on the typical time window after ICI, recurrence upon re‐challenge, elevations of CK, high‐sensitive troponin T (hs‐TnT) and I (hs‐TnI), mild NT‐proBNP increase, and positive magnetic resonance imaging criteria. Notably, hsTnI was found to more rapidly increase and fall and to be more heart‐specific than TnT in the context of ICI‐related myocarditis. This led to ICI therapy withdrawal and switch to a less effective systemic therapy. This case report highlights the differential value of hs‐TnT and hs‐TnI for diagnosis and monitoring of ICI‐related myositis and myocarditis.
Synthesis of Aryl‐ and Alkyl‐Containing 3‐Methylene‐5‐hydroxy Esters via a Barbier Allylation Reaction
Authors: Bartholomäus Albert T. H. , Roman Dávid , Al‐Jammal Walid K. , Vilotijević Ivan , Beemelmanns Christine 
Published: April 2023

AbstractThe formation of C−C bonds via the allylation of carbonyl compounds has been widely applied in total syntheses. Amongst the many possible strategies, the Barbier‐type allylation in aqueous media has received only moderate attention over the last decades despite its mild reaction conditions. In this study, we investigated the indium (In0) and zinc (Zn0) mediated Barbier allylation reaction to efficiently synthesize base‐labile 3‐methylene‐5‐hydroxy containing building blocks for natural product total synthesis. As model study we selected the allylation of lipidic undecanal with ethyl 3‐(bromomethyl)but‐3‐enoate in the presence of either Zn0 or In0 and investigated the effects of additives on yields and selectivities. We then applied the optimized reaction conditions to sterically demanding allyl bromides and functionalized aromatic aldehydes yielding eleven new homoallylic alcohols, one of which was further transformed via oxidation and reduction sequences.
The effect of individual, group, and shared organizational identification on job satisfaction and collective actual turnover
Authors: Avanzi Lorenzo , Perinelli Enrico , Mariani Marco Giovanni 
Published: April 2023

AbstractDrawing on the Social Identity Approach principles, we explored the relationship between organizational identification (individual, group, and shared), job satisfaction, and collective actual turnover. We hypothesize that (a) shared identification moderates the within‐person relationship between individual organizational identification and job satisfaction, namely, the effect is stronger for groups in which the level of shared organizational identification is higher; (b) group job satisfaction mediates the relationship between group organizational identification and collective actual turnover. This study was conducted in a large Italian firm (N = 1090; sale locations = 91). Data were collected using both surveys (e.g., job satisfaction) and archive data (collective actual turnover). By means of Bayesian Multilevel Structural Equation Models, we supported the moderating role played by shared organizational identification in the relationship between individual organizational identification and job satisfaction, while no evidence was found for the mediational hypothesis. We discuss the theoretical and practical implications for management.
Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam
Authors: Saletti Patricia G. , Mowrey Wenzhu B. , Liu Wei , Li Qianyun , McCullough Jesse , Aniceto Roxanne , Lin I‐Hsuan , Eklund Michael , Casillas‐Espinosa Pablo M. , Ali Idrish , Santana‐Gomez Cesar , Coles Lisa , Shultz Sandy R. , Jones Nigel , Staba Richard , O'Brien Terence J. , Moshé Solomon L. , Agoston Denes V. , Galanopoulou Aristea S. ,   for the EpiBioS4Rx Study Group
Published: April 2023

AbstractObjectiveWe used the lateral fluid percussion injury (LFPI) model of moderate‐to‐severe traumatic brain injury (TBI) to identify early plasma biomarkers predicting injury, early post‐traumatic seizures or neuromotor functional recovery (neuroscores), considering the effect of levetiracetam, which is commonly given after severe TBI.MethodsAdult male Sprague–Dawley rats underwent left parietal LFPI, received levetiracetam (200 mg/kg bolus, 200 mg/kg/day subcutaneously for 7 days [7d]) or vehicle post‐LFPI, and were continuously video‐EEG recorded (n = 14/group). Sham (craniotomy only, n = 6), and naïve controls (n = 10) were also used. Neuroscores and plasma collection were done at 2d or 7d post‐LFPI or equivalent timepoints in sham/naïve. Plasma protein biomarker levels were determined by reverse phase protein microarray and classified according to injury severity (LFPI vs. sham/control), levetiracetam treatment, early seizures, and 2d‐to‐7d neuroscore recovery, using machine learning.ResultsLow 2d plasma levels of Thr231‐phosphorylated tau protein (pTAU‐Thr231) and S100B combined (ROC AUC = 0.7790) predicted prior craniotomy surgery (diagnostic biomarker). Levetiracetam‐treated LFPI rats were differentiated from vehicle treated by the 2d‐HMGB1, 2d‐pTAU‐Thr231, and 2d‐UCHL1 plasma levels combined (ROC AUC = 0.9394) (pharmacodynamic biomarker). Levetiracetam prevented the seizure effects on two biomarkers that predicted early seizures only among vehicle‐treated LFPI rats: pTAU‐Thr231 (ROC AUC = 1) and UCHL1 (ROC AUC = 0.8333) (prognostic biomarker of early seizures among vehicle‐treated LFPI rats). Levetiracetam‐resistant early seizures were predicted by high 2d‐IFNγ plasma levels (ROC AUC = 0.8750) (response biomarker). 2d‐to‐7d neuroscore recovery was best predicted by higher 2d‐S100B, lower 2d‐HMGB1, and 2d‐to‐7d increase in HMGB1 or decrease in TNF (P < 0.05) (prognostic biomarkers).SignificanceAntiseizure medications and early seizures need to be considered in the interpretation of early post‐traumatic biomarkers.