bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Vitamin D Level on Sarcopenia in Elderly People: A Critical Review
Authors: Khan Saniya , Kumar Sunil , Acharya Sourya , Wanjari Anil 
Published: January 2023

AbstractVitamin D insufficiency is a widespread health issue globally, particularly among the elderly. Vitamin D controls and affects the metabolism and functionality of several human systems, including muscle tissue. The action of vitamin D on muscles has been extensively studied, with evidence indicating that this vitamin can increase the osteogenic differentiation of muscle fibers, hence preserving and enhancing muscular strength and athletic performance. Low hormone levels are more common in older people as a result of poor food intake and decreased skin ultraviolet irradiation. As a result, elderly persons who are deficient in vitamin D may be at risk of developing sarcopenia, a geriatric condition defined by gradual loss of skeletal muscle mass and strength that is frequently accompanied by adverse events such as falls, incapacity hospitalization, and mortality. As a result, these activities are seen to be crucial in illuminating the underlying functional condition of the aged, and functional mobility is employed as a technique for assessing fall risk and frailty. Several randomized controlled studies have been done to explore the efficacy of oral treatment in elderly people to prevent or cure sarcopenia; however, the results are still debatable. We describe the biochemical, clinical, and epidemiological data supporting the idea of a causal relationship between vitamin D insufficiency and a higher likelihood of sarcopenia in elderly adults in this narrative review. The muscular system, the biggest organ in the body, contributing to around 40% of body composition, is vital in exercising and glycogen depletion. Sarcopenia, a steady deterioration in muscle mass and strength, and function in the aged can result in prolonged circumstances, wheelchair confinement, and a reduction in quality of life. Diagnosis and control of muscle wasting are vital for improving health and quality of life in industrialized nations with aging populations. Vitamin D, a fat-soluble vitamin, has gained popularity in recent years because of its relevance in sarcopenia. The role of vitamin D deficiency and fortification on muscle wasting will be the focus of this review.
Masquelet Procedure for the Treatment of Intra-articular Defects of the Wrist
Authors: Jawahier Priscilla A. , Waaijer Laurien , d'Ailly Philippe N. , Schep Niels W.L. 
Published: January 2023

Abstract
Background The purpose of this case series is to show our experiences with the Masquelet procedure in a variety of infected defects of the wrist.
Case Description All consecutive patients that were treated between 2015 and 2021 were included in this case series. Five patients were included with an infected defect of the wrist, involving the radiocarpal and/or the distal radioulnar joints (DRUJ). All patients underwent thorough debridement of the defect and the created void was filled with a gentamicin/vancomycin cement spacer. Cultures were taken and appropriate antibiotic therapy was initiated. Two patients had a renewal of the cement spacer before definitive surgery. Finally, two patients received a DRUJ prosthesis, two patients had autologous bone grafting and wrist arthrodesis and one patient kept the cement spacer as distal ulna prosthesis due to minor complaints.
Literature Review Current literature provides examples of the Masquelet procedure in traumatic defects or non-unions of the long bones. These cases are almost always about metaphyseal or diaphyseal defects but rarely include intra-articular joint defects therefore no comparisons could be made between the cases we reported with any existing literature.
Clinical Relevance The Masquelet procedure showed to be effective in eradicating infected defects of the wrist involving the radiocarpal joint and/or DRUJ. All patients had an aseptic environment before performing definitive surgery. This technique showed to be save and no reinfections occurred.
Application of an in silico approach identifies a genetic locus within ITGB2, and its interactions with HSPG2 and FGF9, to be associated with anterior cruciate ligament rupture risk
Authors: Dlamini Senanile B. , Saunders Colleen J. , Laguette Mary‐Jessica N. , Gibbon Andrea , Gamieldien Junaid , Collins Malcolm , September Alison V. 
Published: January 2023

ABSTRACTWe developed a Biomedical Knowledge Graph model that is phenotype and biological function‐aware through integrating knowledge from multiple domains in a Neo4j, graph database. All known human genes were assessed through the model to identify potential new risk genes for anterior cruciate ligament (ACL) ruptures and Achilles tendinopathy (AT). Genes were prioritised and explored in a case–control study comparing participants with ACL ruptures (ACL‐R), including a sub‐group with non‐contact mechanism injuries (ACL‐NON), to uninjured control individuals (CON). After gene filtering, 3376 genes, including 411 genes identified through previous whole exome sequencing, were found to be potentially linked to AT and ACL ruptures. Four variants were prioritised: HSPG2:rs2291826A/G, HSPG2:rs2291827G/A, ITGB2:rs2230528C/T and FGF9:rs2274296C/T. The rs2230528 CC genotype was over‐represented in the CON group compared to ACL‐R (p < 0.001) and ACL‐NON (p < 0.001) and the TT genotype and T allele were over‐represented in the ACL‐R group and ACL‐NON compared to CON (p < 0.001) group. Several significant differences in distributions were noted for the gene‐gene interactions: (HSPG2:rs2291826, rs2291827 and ITGB2:rs2230528) and (ITGB2:rs2230528 and FGF9:rs2297429). This study substantiates the efficiency of using a prior knowledge‐driven in silico approach to identify candidate genes linked to tendon and ACL injuries. Our biomedical knowledge graph identified and, with further testing, highlighted novel associations of the ITGB2 gene which has not been explored in a genetic case control association study, with ACL rupture risk. We thus recommend a multistep approach including bioinformatics in conjunction with next generation sequencing technology to improve the discovery potential of genomics technologies in musculoskeletal soft tissue injuries.
Effects of the Nike ZoomX Vaporfly Next% 2 shoe on long‐interval training performance, kinematics, neuromuscular parameters, running power and fatigue
Authors: Castellanos‐Salamanca Mario , Rodrigo‐Carranza Víctor , Rodríguez‐Barbero Sergio , González‐Ravé José María , Santos‐Concejero Jordan , González‐Mohíno Fernando 
Published: January 2023

ABSTRACTWe analysed the effects of the Nike ZoomX Vaporfly (VPF) on long‐interval training performance, kinematic parameters, running power and fatigue compared to a traditional running shoe. Twelve well‐trained men (mean ± SD: 32.91 ± 7.50 years; 69.29 ± 7.55 kg and 172.73 ± 5.97 cm) performed two long‐interval training sessions (5 × 1000 m with 90s recovery period) 7 days apart, with the VPF shoe or a traditional running shoe (CON) in random order. The countermovement jump (CMJ) height was measured before and after the training sessions and heart rate, spatiotemporal parameters, running power and leg stiffness was measured during training sessions. Running‐related pain was assessed prior and post‐24 h of each training session. Long‐interval training performance improved 2.4% using the VPF shoe compared to CON (p = 0.009; ES = 0.482). Step length, contact time and leg stiffness were higher (p < 0.05; ES = 0.51, ES = 0.677, ES = 0.356) while flight time was lower (p < 0.001; ES = 0.756) when using VPF. Running power decreased in a similar way in both conditions throughout the training session. Vertical power was significantly higher in the VPF condition (p = 0.023, ES = 0.388). CMJ height decreased in both conditions after training (4.7 vs. 7.2%, for the VPF and control, respectively, p < 0.001; ES = 0.573). Finally, the perceived muscle pain was influenced by the shoe model condition (chi‐square 5.042, P = 0.025). VPF shoes improved the long‐interval training performance with similar running power, heart rate and neuromuscular fatigue, and reduced subjective perceived muscle pain compared to regular training shoes.
Echinocandin exposures in obese patients: A scoping review and clinical perspectives
Authors: Alsowaida Yazed S , Alamer Ahmad , Thabit Abrar K , Almulhim Abdulaziz S , Aleissa Muneerah M , Kalbasi Alireza , Eljaaly Khaled , Almangour Thamer A , Erstad Brian L 
Published: January 2023

AbstractPurposeEchinocandins are favored drugs for the treatment of fungal infections. There is growing evidence that obese patients treated with echinocandins have lower exposures due to pharmacokinetic (PK) alterations. We conducted a scoping review to characterize, evaluate, and summarize the available evidence on echinocandins exposures in obese patients.SummaryA comprehensive search of PubMed, Embase, and Cochrane Library for studies on echinocandins published from database inception to October 28, 2022, was conducted using PRISMA-ScR methodology. A total of 25 studies comprising more than 3,174 subjects (8 micafungin studies, 7 caspofungin studies, 9 anidulafungin studies, and 1 rezafungin study) were included in this review. Seventeen studies reported lower echinocandins exposures in overweight and obese individuals compared with normal-weight individuals; the authors of these studies recommended dose adjustments. Conversely, 8 studies did not find significant differences in echinocandin exposure among subjects in varying body weight categories. Clinicians may consider dose adjustments of echinocandins in obese patients; however, there is limited evidence on the ideal dose adjustment strategy to overcome the low echinocandins exposures in obese patients.ConclusionThis scoping review shed light on a growing body of evidence indicating that obese patients have lower echinocandin exposures relative to targeted PK indices, which may lead to negative therapeutic implications. Currently, a lack of high-quality evidence impedes reaching consensus on recommendations for echinocandin dosing adjustment in obese patients. Future research evaluating the optimal echinocandin dosing strategy for obese patients is needed.
Pharmacist-led improvement in perioperative antibiotic selection for patients with a penicillin allergy label
Authors: Stonerock Devon , Hallo-Carrasco Alejandro , Edwards Michael , Porter Steven B , Epps Kevin L , Gonzalez-Estrada Alexei 
Published: January 2023

Abstract

Purpose
Surgical patients with a penicillin allergy label (PAL) are less likely to receive β-lactams for surgical site infection (SSI) prophylaxis and more likely to receive second-line antibiotics, which may increase the risk of SSI, drug toxicities, and associated costs. We assessed the impact of implementing a pharmacist-led quality improvement project to increase the use of cefazolin as a first-line agent in this population.

Summary
After implementation of a pilot project in December 2021, all patients with a PAL and orders for preoperative antibiotics were risk stratified into high- or low-risk categories by a pharmacist. For the low-risk group, cefazolin was recommended. For the high-risk group, cefazolin was avoided and a second-line agent was administered. Our analysis compared 422 preintervention patients (August 15 to November 15, 2021) to 492 postintervention patients (December 15 to March 15, 2022). During the postintervention period, β-lactam usage increased (from 12.6% to 37.8%, P &lt; 0.001), while usage of vancomycin (45.5% vs 29.5%, P &lt; 0.001) and other second-line antibiotics (87.4% vs 62.2%, P &lt; 0.001) declined. There were no adverse reactions reported in the preintervention cohort, with 2 potential adverse reactions reported after the intervention (0% vs 0.4%, P = 0.190). Medication costs based on claims data were 50% to 80% lower for patients receiving cefazolin.

Conclusion
In our cohort, a pharmacy-led antibiotic selection algorithm for patients with a PAL receiving perioperative antimicrobial prophylaxis resulted in increased use of β-lactam antibiotics, decreased use of second-line antibiotics, and decreased costs without a significant change in the incidence of adverse reactions.
From Silence to Silencing? Contradictions and Tensions in Language Revitalization
Authors: Lane Pia 
Published: January 2023

Abstract
Language revitalization is imbued with tensions, and while it often is emancipatory, reclaiming a language can be a painful, silencing experience. Processes of colonization have led to epistemological absences (Santos 2012), which may be conceptualized as manifestations of silence. Understanding how and why silences come about and linger today is important for overcoming challenges those engaging in language reclamation may face. Therefore, paying attention to silences and emotional aspects of revitalization processes is important. In order to explore the inherent tensions of revitalization processes, I investigate lived experiences of language reclamation, focusing on emotions and silences in revitalization processes of Sámi in Northern Norway. European nation states colonized not only in the global South, but also ‘at home’. Thus, the South, in the form of silenced and marginalized populations, also exists in the global North (Santos 2012). Drawing on perspectives from Southern Theory and Gordon’s (2017) sociology of haunting, I investigate silences, emotions and tensions in language reclamation to shed light on how our colonial past may re-emerge in processes of language reclamation.
Immediate CT after hospital arrival and decreased in-hospital mortality in severely injured trauma patients
Authors: Yamamoto Ryo , Suzuki Masaru , Funabiki Tomohiro , Sasaki Junichi 
Published: January 2023

AbstractBackgroundImmediate whole-body CT (about 10 min after arrival) in an all-in-one resuscitation room equipped with CT has been found to be associated with shorter time to haemostasis and lower in-hospital mortality. The aim of this study was to elucidate the benefits of immediate whole-body CT after hospital arrival in patients with severe trauma with the hypothesis that immediate CT within 10 min is associated with lower in-hospital mortality.MethodThis retrospective cohort study of patients with an injury severity score of more than 15 who underwent whole-body CT was conducted using the Japanese Trauma Databank (2019–2020). An immediate CT was conducted within 10 min after arrival. In-hospital mortality, frequency of subsequent surgery, and time to surgery were compared with immediate and non-immediate CT. Inverse probability weighting was conducted to adjust for patient backgrounds, including mechanism and severity of injury, prehospital treatment, vital signs, and institutional characteristics.ResultsAmong the 7832 patients included, 646 underwent immediate CT. Immediate CT was associated with lower in-hospital mortality (12.5 versus 15.7 per cent; adjusted OR 0.77 (95 per cent c.i. 0.69 to 0.84); P &lt; 0.001) and fewer damage-control surgeries (OR 0.75 (95 per cent c.i. 0.65 to 0.87)). There was a 10 to 20 min difference in median time to craniotomy, laparotomy, and angiography. These benefits were observed regardless of haemodynamic instability on hospital arrival, while they were identified only in elderly patients with severe injury and altered consciousness.ConclusionImmediate CT within 10 min after arrival was associated with decreased in-hospital mortality in severely injured trauma patients.
Suspected Non-ST-elevation acute coronary syndrome meeting rapid rule-out criteria: resource utilization, diagnostic yield, and clinical outcomes of hospital admission
Authors: Cohen Ben , Cohen Sharon , Tor Ruth , Shochat Tzippy , Fuchs Shmuel , Kornowski Ran , Grossman Alon , Hasdai David 
Published: January 2023

Abstract

Aims
Many patients with suspected non-ST-elevation (NSTE) acute coronary syndromes (ACS) are admitted, even those with initial high-sensitivity cardiac troponins (hs-cTn) values who meet rapid rule-out criteria for myocardial infarction (MI). We examined the clinical outcomes, resource utilization, and diagnostic yield of suspected NSTE-ACS patients, who presented with hs-cTnT values meeting these criteria but were nevertheless hospitalized.

Methods and results
Applying the 2020 European Society of Cardiology (ESC) rapid rule-out MI criteria, we identified consecutive patients with an initial value of hs-cTnT &lt;5 ng/L or an initial value of ≥5 ng/L but &lt;14 ng/L (99th percentile) and a small increment in a subsequent test, who were nevertheless admitted. The majority (85.4%) of patients presented to the emergency department (ED) with suspected NSTE-ACS had an initial hs-cTnT &lt;99th percentile. We examined 3775 admitted patients out of 11 477 patients who were triaged and met MI rule-out criteria. Only 0.32% (12 patients) of admitted patients experienced index MI or overall death within 30 days. Resource utilization in terms of ED stay, hospital stay, noninvasive and invasive tests was substantial, yet revascularization was uncommon (2.5%). Multivariate adjustment for age, gender, and baseline cardiovascular risk factors demonstrates similar survival of admitted vs. discharged patients (P = 0.88). Initial hs-cTnT even below the 99th percentile provided a prognostic stratification for long term mortality.

Conclusion
Our findings support a policy of ED discharge of suspected NSTE-ACS patients meeting rapid MI rule-out criteria and subsequent ambulatory evaluation, sparing resource-consuming admissions. In-hospital and ensuing prognosis were better with lower initial hs-cTnT values.
The source of uncertainty influences technology adoption
Authors: Singerman Ariel , Lence Sergio H 
Published: January 2023

AbstractWe shed light on Florida citrus growers’ decisions regarding their adoption of scientifically untested antibiotic sprays over insecticide spray coordination for dealing with the devastating impact of a pernicious plant disease. Using data from a framed field economic experiment, we examine growers’ preferences towards two types of uncertain outcomes, the first resulting from a game against nature and the second involving strategic interaction. We find evidence that, on average, growers prefer the game against nature. Moreover, we find that they prefer such a game even for ranges over which the game involving strategic interaction has a higher likelihood of success. The results and insights we obtain help better understand growers’ preferences over different types of uncertainty, which can play a key role in their technology adoption decisions. Our findings should be useful for policymakers to realise the implications of allowing the use of uncertain technologies and the detrimental impact they can have in dealing with issues that involve externalities such as those present in pest and disease management.
Geographic isolation alone does not explain divergence of a group of orchid species across Brazil’scampos rupestressky-islandsIsolamento geográfico por si só não explica a divergência de um grupo de espécies de orquídeas nos campos rupestres do Brasil
Authors: Fiorini Cecilia F , Borba Eduardo Leite , Resende-Moreira Luciana C , de Camargo Smidt Eric , Knowles L Lacey 
Published: January 2023

AbstractMountains play a crucial role in the origin and maintenance of Neotropical biodiversity, but there are still unanswered questions about the diversification of the campos rupestres (CR), an herbaceous-shrubby sky-island vegetation in eastern South America. For orchids distributed across this disjunct rock habitat, difficulties with distinguishing morphological taxa add an additional challenge to disentangling the history of divergence. Here, we combined the power of ddRAD genomic data with broad sampling of Bulbophyllum sect. Didactyle (Orchidaceae), across the CR and other Neotropical outcrops, to estimate evolutionary relationships and evaluate the biogeography of the group’s diversification. Although genetic lineages generally align with geographic disjunctions, we also observe distantly related lineages within some previously recognized species. For such taxa, their lack of monophyly and a shared regional divergence pattern suggests a complex history that may include unrecognized diversity. When viewed through the lens of morphological variability, our study raises intriguing questions about the persistence and permeability of species barriers among orchid populations. These results, in addition to the recency of the divergence history of B. sect. Didactyle, provide insights about hypothesized community level vs. species-specific paths of diversification across the Neotropical sky-islands of the CR.
Restoration age and reintroduced bison may shape soil bacterial communities in restored tallgrass prairies
Authors: Barber Nicholas A , Klimek Desirae M , Bell Jennifer K , Swingley Wesley D 
Published: January 2023

Abstract
Knowledge of how habitat restoration shapes soil microbial communities often is limited despite their critical roles in ecosystem function. Soil community diversity and composition change after restoration, but the trajectory of these successional changes may be influenced by disturbances imposed for habitat management. We studied soil bacterial communities in a restored tallgrass prairie chronosequence for &gt;6 years to document how diversity and composition changed with age, management through fire, and grazing by reintroduced bison, and in comparison to pre-restoration agricultural fields and remnant prairies. Soil C:N increased with restoration age and bison, and soil pH first increased and then declined with age, although bison weakened this pattern. Bacterial richness and diversity followed a similar hump-shaped pattern as soil pH, such that the oldest restorations approached the low diversity of remnant prairies. β-diversity patterns indicated that composition in older restorations with bison resembled bison-free sites, but over time they became more distinct. In contrast, younger restorations with bison maintained unique compositions throughout the study, suggesting bison disturbances may cause a different successional trajectory. We used a novel random forest approach to identify taxa that indicate these differences, finding that they were frequently associated with bacteria that respond to grazing in other grasslands.
Functional significance of microbial diversity in arid soils: biological soil crusts and nitrogen fixation as a model system
Authors: Barrón-Sandoval Alberto , Martiny Jennifer B H , Pérez-Carbajal Teresa , Bullock Stephen H , Leija Alfonso , Hernández Georgina , Escalante Ana E 
Published: January 2023

Abstract
Microbial communities respond to changes in environmental conditions; however, how compositional shifts affect ecosystem processes is still not well-understood and it is often assumed that different microbial communities will function equally under similar environmental conditions. We evaluated this assumption of functional redundancy using biological soil crusts (BSCs) from two arid ecosystems in Mexico with contrasting climate conditions (hot and cold deserts) following an experimental approach both in the field (reciprocal transplants) and in laboratory conditions (common garden), focusing on the community’s composition and potential for nitrogen fixation. Potential of nitrogen fixation was assessed through the acetylene reduction assay. Community composition and diversity was determined with T-RFLPs of nifH gene, high throughput sequencing of 16S rRNA gene amplicons and metagenomic libraries. BSCs tended to show higher potential nitrogen fixation rates when experiencing temperatures more similar to their native environment. Moreover, changes in potential nitrogen fixation, taxonomic and functional community composition, and diversity often depended on an interactive effect of origin of the communities and the environment they experienced. We interpret our results as legacy effects that result from ecological specialization of the BSC communities to their native environment. Overall, we present evidence of nonfunctional redundancy of BSCs in terms of nitrogen fixation.