bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐entropy Electrolyte Enables High Reversibility and Long Lifespan for Magnesium Metal Anodes
Authors: Wang Shiyang , Wang Kewei , Zhang Yuchen , Jie Yulin , Li Xinpeng , Pan Yuxue , Gao Xiaowen , Nian Qingshun , Cao Ruiguo , Li Qi , Jiao Shuhong , Xu Dongsheng 
Published: June 2023

AbstractThe stable cycling of Mg‐metal anodes is limited by several problems, including sluggish electrochemical kinetics and passivation at the Mg surface. In this study, we present a high‐entropy electrolyte composed of lithium triflate (LiOTf) and trimethyl phosphate (TMP) co‐added to magnesium bis(trifluoromethane sulfonyl)imide (Mg(TFSI)2/1,2‐dimethoxyethane (DME) to significantly improve the electrochemical performance of Mg‐metal anodes. The as‐formed high‐entropy Mg2+‐2DME‐OTf−‐Li+‐DME‐TMP solvation structure effectively reduced the Mg2+‐DME interaction in comparison with that observed in traditional Mg(TFSI)2/DME electrolytes, thereby preventing the formation of insulating components on the Mg‐metal anode and promoting its electrochemical kinetics and cycling stability. Comprehensive characterization revealed that the high‐entropy solvation structure brought OTf− and TMP to the surface of the Mg‐metal anode and promoted the formation of a Mg3(PO4)2‐rich interfacial layer, which is beneficial for enhancing Mg2+ conductivity. Consequently, the Mg‐metal anode achieved excellent reversibility with a high Coulombic efficiency of 98 % and low voltage hysteresis. This study provides new insights into the design of electrolytes for Mg‐metal batteries.
A Multifunctional Liquid Crystal as Hole Transport Layer Additive Enhances Efficiency and Stability of Perovskite Solar Cells
Authors: Lai Qian , Zhuang Rongshan , Zhang Kun , Wu Tai , Xie Lin , Zhao Rongjun , Yang Lei , Wang Yang , Hua Yong 
Published: June 2023

AbstractLithium bis(trifluoromethanesulfonyl)imide (Li‐TFSI) has been identified as the most used and effective p‐dopant for hole transport layer (HTL) in perovskite solar cells (PSCs). However, the migration and agglomeration of Li‐TFSI in HTL negatively impact PSCs performance and stability. Herein, we report an effective strategy for adding a liquid crystal organic small molecule (LQ) into Li‐TFSI doped (2,2′,7,7′‐tetrakis(N,N‐di‐p‐methoxyphenylamine)‐9,9′‐ spirobifluorene (Spiro‐OMeTAD) HTL. It was found that the introduction of LQ into Spiro‐OMeTAD HTL can efficiently enhance the charge carrier extraction and transportation in device, which can strongly retard the charge carrier recombination in device. Consequently, the PSCs efficiency is significantly enhanced to 24.42 % (Spiro‐OMeTAD+LQ) from 21.03 % (Spiro‐OMeTAD). The chemical coordination between LQ and Li‐TFSI can strongly confine Li+ ions migration and agglomeration of Li‐TFSI, thus, achieving the enhanced device stability. Only a 9 % efficiency degradation is observed for un‐encapsulated device prepared with Spiro‐OMeTAD and LQ after 1700 h under air environment, while the efficiency drops by 30 % for the reference device. This work provides an effective strategy for improving the efficiency and stability of PSCs, and gives some important insights for understanding intrinsic hot carriers dynamics for perovskite‐based optoelectronic devices.
A DNA‐Gated and Self‐Protected Bioorthogonal Catalyst for Nanozyme‐Assisted Safe Cancer Therapy
Authors: Zhang Yanjie , Zhang Lu , Wang Wenjie , Deng Qingqing , Liu Mengmeng , Zhu Zitong , Liu Hao , Ren Jinsong , Qu Xiaogang 
Published: June 2023

AbstractTransition metal catalysts (TMCs) mediated bioorthogonal uncaging catalysis has sparked increasing interest in prodrug activation. However, due to their “always‐on” catalytic activity as well as the complex and catalytic‐detrimental intracellular environment, the biosafety and therapeutic efficiency of TMCs are unsatisfactory. Herein, a DNA‐gated and self‐protected bioorthogonal catalyst has been designed by modifying nanozyme‐Pd0 with highly programmable nucleic acid (DNA) molecules to achieve efficient intracellular drug synthesis for cancer therapy. Monolayer DNA molecules could endow the catalyst with targeting and perform as a gatekeeper to achieve selective prodrug activation within cancer cells. Meanwhile, the prepared graphitic nitrogen‐doped carbon nanozyme with glutathione peroxidase (GPx) and catalase (CAT)‐like activities could improve the catalytic‐detrimental intracellular environment to prevent the catalyst from being inactivated and sensitize the subsequent chemotherapy. Overall, we believe that our work will promote the development of secure and efficient bioorthogonal catalytic systems and provide new insights into novel antineoplastic platforms.
Programmed Pore‐Shape Fixing in a Soft Porous Molecular Crystal—Navigating the Phase Interconversion Landscape
Authors: Eaby Alan C. , Loots Leigh , Basson Jeanice L. , Esterhuysen Catharine , Barbour Leonard J. 
Published: June 2023

AbstractPore‐shape fixing effects (PSFEs) in soft porous crystals are a relatively unexplored area of materials chemistry. We report the PSFE in the prototypical dynamic van der Waals solid p‐tert‐butylcalix[4]arene (TBC4). Starting with the high‐density guest‐free phase, two porous shape‐fixed phases were programmed using the stimuli of CO2 pressure and temperature. A suite of complementary in situ techniques, including variable‐pressure (VP) single‐crystal X‐ray diffraction, VP powder X‐ray diffraction, VP differential scanning calorimetry, volumetric sorption analysis, and attenuated total reflectance Fourier‐transform infrared spectroscopy was used to track dynamic guest‐induced transformations, providing molecular‐level insight into the PSFE. The interconversion between the two metastable phases is particle size dependent, making this the second example of the PSFE by crystal downsizing, and the first example involving a porous molecular crystal: larger particles undergo reversible transitions while smaller particles remain fixed in the metastable phase. A complete phase interconversion scheme was constructed for the material, thus allowing navigation of the phase interconversion landscape of TBC4 using the easily applied stimuli of CO2 pressure and thermal treatment.
Designed Tetranuclear Iron‐oxo Clusters with Redox Activity for High‐Performance Lithium Storage
Authors: Lv Jia‐Qi , Li Bo , Liu Qianqian , Gao Zhixin , Lang Zhong‐Ling , Liang Song , Li Yingqi , Zang Hong‐Ying 
Published: June 2023

AbstractPolyoxometalates (POMs) are considered as promising catalysts with unique redox activity at the molecular level for energy storage. However, eco‐friendly iron‐oxo clusters with special metal coordination structures have rarely been reported for Li‐ion storage. Herein, three novel redox‐active tetranuclear iron‐oxo clusters have been synthesized using the solvothermal method with different ratios of Fe3+ and SO42−. Further, they can serve as anode materials for Li‐ion batteries. Among them, cluster H6[Fe4O2(H2O)2(SO4)7]⋅H2O, the stable structure extended by SO42− with a unique 1D pore, displays a specific discharge capacity of 1784 mAh g−1 at 0.2 C and good cycle performance (at 0.2 C and 4 C). This is the first instance of inorganic iron‐oxo clusters being used for Li‐ion storage. Our findings present a new molecular model system with a well‐defined structure and offer new design concepts for the practical application of studying the multi‐electron redox activity of iron‐oxo clusters.
Single‐Phase Growth, Stabilization, and Electrical Properties of B Phase VO2 Films Grown on Mica by Reactive Magnetron Sputtering
Authors: Ekström E. , Hurand S. , Yildizhan M. M. , Elsukova A. , Persson P. O. Å. , Paul B. , Ramanath G. , le Febvrier A. , Eriksson F. , Eklund P. 
Published: June 2023

AbstractThe VO2 metastable (B) phase is of interest for applications in temperature sensing, bolometry, and Li‐ion batteries. However, single‐phase growth of thin films of this metastable phase is a challenge because vanadium oxide exhibits many polymorphs and the VO2 stable (M1) phase is usually present as a secondary phase. Additionally, the phase transition at 350 °C in the (B) phase severely narrows the processing window for achieving phase‐pure films. Here, single‐phase growth of 5‐to 50‐nm thick VO2 (B) films on muscovite, mica, by pulsed direct‐current reactive magnetron sputtering at 400 °C is demonstrated. The films are phase‐pure and exhibit a high density of 4.05 g cm−3 and low resistivity of about 50 mΩcm at 30 °C. Increasing the film thickness to 100 nm results in a V2O5‐capped VO2 (B) film with a resistivity of 8000 mΩcm. These results indicate that the stability of the VO2 (B) phase is sensitive to in situ annealing during deposition. These findings should serve as a basis to design processes to exclusively obtain phase‐pure VO2 (B) films.
Fabrication of oxygen‐carrying microparticles functionalized with liver ECM‐proteins to improve phenotypic three‐dimensional in vitro liver assembly, function, and responses
Authors: Mansouri Mona , Imes William D. , Roberts Owen S. , Leipzig Nic D. 
Published: June 2023

AbstractOxygen and extracellular matrix (ECM)‐derived biopolymers play vital roles in regulating many cellular functions in both the healthy and diseased liver. This study highlights the significance of synergistically tuning the internal microenvironment of three‐dimensional (3D) cell aggregates composed of hepatocyte‐like cells from the HepG2 human hepatocellular carcinoma cell line and hepatic stellate cells (HSCs) from the LX‐2 cell line to enhance oxygen availability and phenotypic ECM ligand presentation for promoting the native metabolic functions of the human liver. First, fluorinated (PFC) chitosan microparticles (MPs) were generated with a microfluidic chip, then their oxygen transport properties were studied using a custom ruthenium‐based oxygen sensing approach. Next, to allow for integrin engagements the surfaces of these MPs were functionalized using liver ECM proteins including fibronectin, laminin‐111, laminin‐511, and laminin‐521, then they were used to assemble composite spheriods along with HepG2 cells and HSCs. After in vitro culture, liver‐specific functions and cell adhesion patterns were compared between groups and cells showed enhanced liver phenotypic responses to laminin‐511 and 521 as evidenced via enhanced E‐cadherin and vinculin expression, as well as albumin and urea secretion. Furthermore, hepatocytes and HSCs exhibited more pronounced phenotypic arrangements when cocultured with laminin‐511 and 521 modified MPs providing clear evidence that specific ECM proteins have distinctive roles in the phenotypic regulation of liver cells in engineering 3D spheroids. This study advances efforts to create more physiologically relevant organ models allowing for well‐defined conditions and phenotypic cell signaling which together improve the relevance of 3D spheroid and organoid models.
Association between ambient temperature and risk of stroke morbidity and mortality: A systematic review and meta‐analysis
Authors: Wen Jing , Zou Li , Jiang Ziwen , Li Yufeng , Tao Jiaxin , Liu Yifang , Fu Wenning , Bai Xue , Mao Jing 
Published: June 2023

AbstractBackgroundPrevious studies have suggested that ambient temperature is associated with the morbidity and mortality of stroke although results among these investigations remained unclear. Therefore, the purpose of present meta‐analysis was to summarize the evidence of the relationship between ambient temperature and stroke morbidity and mortality.MethodsA systematic search of the PubMed, Embase, and Web of Science databases was from inception to April 13, 2022. The pooled estimates for heat ambient temperature and cold ambient temperature, which were defined as comparison between extreme hot or cold conditions and the reference or threshold temperature, were calculated utilizing a random‐effects model. A total of 20 studies were included in the meta‐analysis.ResultsThe pooled estimated show that the heat ambient temperature was significant associated with 10% (relative risk [RR], 1.10; 95% confidence interval [95%CI]: 1.02–1.18) and 9% (RR, 1.09; 95%CI: 1.02–1.17) increase in the risk of stroke morbidity and mortality, respectively. In addition, the pooled estimated show that the cold ambient temperature was significant associated with 33% (RR, 1.33; 95%CI: 1.17–1.51) and 18% (RR, 1.18; 95%CI: 1.06–1.31) increase in the risk of stroke morbidity and mortality, respectively.ConclusionIntegrated epidemiological evidence supports the hypothesis that both heat and cold ambient temperature have positive association with the risk of stroke morbidity and mortality. Targeted measures should be promoted in public health to reduce this risk.
Comparison of breast‐conserving surgery without radiotherapy and mastectomy in the treatment of elderly patients with early breast cancer: A PSM and SEER database study
Authors: Fu Baiyang , Chen Xi , Liang Wenlong , Wang Yao , Yao Yuan , Zhang Jianguo 
Published: June 2023

AbstractBackgroundAt present, there is no research on which surgical method can lead to a better prognosis in elderly patients with early breast cancer. The purpose of this study was to establish a nomogram to predict the survival outcome of elderly patients with early breast cancer and to compare the prognosis of the breast‐conserving surgery (BCS) group who did not receive postoperative radiotherapy and the mastectomy group through risk stratification.MethodsThis study included patients with early breast cancer aged ≥70 years from the Surveillance, Epidemiology, and End Results database (n = 20,520). The group was randomly divided into a development cohort (n = 14,363) and a validation cohort (n = 6157) according to a ratio of 7:3. Risk factors affecting overall survival (OS) and breast‐cancer‐specific survival (BCSS) were analyzed using univariate and multivariate Cox regression. Present results were obtained by constructing nomograms and risk stratifications. Nomograms were evaluated by the concordance index and calibration curve. Kaplan–Meier curves were established based on BCSS and analyzed using the log‐rank test.ResultsMultivariate Cox regression results showed that age, race, pathological grade, T and N stages, and progesterone receptor (PR) status were independent risk factors for OS and BCSS in the BCS group and mastectomy group. Subsequently, they were incorporated into nomograms to predict 3‐ and 5‐year OS and BCSS in patients after BCS and mastectomy. The concordance index was between 0.704 and 0.832, and the nomograms also showed good calibration. The results of risk stratification showed that there was no survival difference between the BCS group and the mastectomy group in the low‐risk and high‐risk groups. In the middle‐risk group, BCS improved the BCSS of patients to a certain extent.ConclusionThis study constructed a well‐performing nomogram and risk stratification model to assess the survival benefit of BCS without postoperative radiotherapy in elderly patients with early breast cancer. The results of the study can help clinicians analyze the prognosis of patients and the benefits of surgical methods individually.
Phyto‐Pharmacological Review onMurraya koenigii(L.) Spreng: As an Indigenous Plant of India with High Medicinal Potential
Authors: Singh Sonia , Ahuja Ashima , Murti Yogesh , Khaliq Afshan 
Published: June 2023

AbstractThe medicinal aspects ofMurraya koenigii(L.) Spreng. It also provides the latest updated information on pharmacological and plant patents on phytoconstituents. The information was collected from various sources, including literature surveys, textbooks, databases, and internet sources like Scopus, Science Direct, Pubmed, Springer, Google Scholar, Taylor and Francis. The plant,Murraya koenigii(L.) Spreng is an extensive valuable, and important medicinal plant in the Indian System of Medicine. The plant proved to show various ethnomedicinal uses mentioned in the literature and even possessed various pharmacological activities. Different bioactive metabolites exhibit several biological activities. However, the biological efficacies of various other chemical constituents are yet to be clarified and proved concerning the molecular mechanisms.
Hyposterolactone A, a 3α‐Hydroxy Steroidal Lactone from the Deep‐Sea‐Derived FungusHypocreasp. ZEN14
Authors: Xu Lin , Ma Hua‐Bin , Wu Taizong , Liu Li‐Fang , Xie Ming‐Min , Hu Man‐Yi , Gai Ying‐Bao , Zhong Tian‐Hua , Yang Xian‐Wen 
Published: June 2023

AbstractChemical investigation of the deep‐sea‐derived fungusHypocreasp. ZEN14 afforded a new 3α‐hydroxy steroidal lactone, hyposterolactone A (1) and 25 known secondary metabolites (2–26). The structure of the new compound was established by detailed spectroscopic analysis, electronic circular dichroism (ECD) calculation as well as aJ‐based configuration analysis. Compound10showed potent cytotoxicity against Huh7 and Jurkat cells with IC50values of 1.4 μM and 6.7 μM, respectively.
Synergistic Coupling of Photocatalysis and Thermocatalysis for Efficient CO2 Conversion by Direct Z‐Scheme WO3/WS2
Authors: Zhang Xiaoyue , Yang Yong , Xiong Lijun , Wang Tianyu , Xue Mengwei , Ge Jianhua , Tang Zheng , Li Panjie , Yin Nan , Shen Jinyou 
Published: June 2023

AbstractPhotothermal CO2 reduction using H2O combined with photocatalysis‐driven H2O splitting combined with thermal catalysis‐supported CO2 reduction has attracted rapid interest in artificial synthesis of solar fuel. With respect to extremely efficient photothermal catalysis, the photothermal impact of TMDCs (Transition Metal Dichalcogenides) facilitates CO2 reduction by activating lattice oxygen in oxide to enhance H2O oxidation. However, the fixed band gap of single photocatalyst is limited. The purpose of this work is to expand the band gap and improve the redox capacity. Hollow boxwood ball‐like WO3/WS2 Z‐scheme heterojunctions were prepared and used for photothermal catalytic CO2 reduction. DFT calculations and UV‐Vis spectra show LSPR effect in WOS heterojunctions, and the optical response extends to near infrared region. By comparison, the photothermal catalytic reduction of WO3/WS2 (9.717 μmol) by CO2 at 513 K is higher than that at 298 K (1.198 μmol) by a factor of 8. The formation of Z‐scheme heterojunction promotes rapid carrier transfer and lowers the reaction energy barrier. As well as the hollow structure improves light utilization and increases the interfacial area and number of active sites. In addition, the WO3/WS2 heterostructure utilizes its unique LSPR effect to generate heat through the photothermal effect, which can also promote molecular activation. This work reveals the important role of the LSPR effect in photothermal catalysis and demonstrates a TMDCs‐based photothermal‐driven catalysts, which presents a promising approach for designing of photothermal catalytic CO2 reduction.
Synthesis of 3‐Azabicyclo[3.1.0]hexane Derivates
Authors: Li Yufeng , Feng Jiajun , Huang Fei , Baell Jonathan B. 
Published: June 2023

Abstract3‐Azabicyclo[3.1.0]hexanes are an important class of nitrogen‐containing heterocycles that have been found to be key structural features in a wide range of biologically active natural products, drugs, and agrochemicals. As a cutting‐edge area, the synthesis of these derivatives has made spectacular progress in recent decades, with various transition‐metal‐catalyzed and transition‐metal‐free catalytic systems being developed. In this review, we provide an overview of recent advances in the efficient methods for the synthesis of 3‐azabicyclo[3.1.0]hexane derivatives since 2010, emphasizing the scope of substrates and synthesis’ applications, as well as the mechanisms of these reactions.
Unlocking The Role of Guanidinium Salts in Interface Engineering for Boosted Performance of Inverted Perovskite Solar Cells
Authors: Ren Haorong , Wu Qiaofeng , Yu Yue , Liu Rui , Xu Maoxia , Hu Kexin , Yang Chengbin , Zhang Zetan , Deng Chen , Li Jinyu , Yu Hua 
Published: June 2023

AbstractNiOx‐based inverted perovskite solar cells (PSCs) have attracted growing attention due to their low cost and large‐scale application potential. However, the efficiency and stability of inverted planar heterojunction PSCs is still unsatisfactory owing to insufficient charge‐extraction caused by undesirable interfacial contact between perovskite and NiOx hole transport layers (HTLs). Herein an interfacial passivation strategy with guanidinium salts (guanidinium thiocyanate (GuASCN), guanidine hydrobromide (GuABr), guanidine hydriodate (GuAI)) as passivator is employed to solve this problem. We systematically study the effect of various guanidinium salts on the crystallinity, morphology, and photophysical properties of perovskite films. Guanidine salt as interfacial passivator can decrease interface resistance, reduce carrier non‐radiative recombination, and boost carrier extraction. Notably, the GuABr‐treated unencapsulated devices can still maintain more than 90 % of their initial PCE after aging for 1600 h at 16–25 °C and 35 %–50 % relative humidity in ambient conditions. This work reveals the significance of counterions in improving the photovoltaic performance and stability of PSCs.
Patient‐specific hemodynamic feature of central venous disease intervened by stent: A numerical study
Authors: Wang Zhaoli , Li Tao , Zhou Jingyuan , Yu Yang , Chen Yu , Fu Ping 
Published: June 2023

AbstractCentral venous disease (CVD) with stenosis or occlusion is a severe and prevalent complication for chronic hemodialysis (HD) patients, resulting in dialysis access dysfunction. Percutaneous transluminal angioplasty with stent placement (PTS) has become one of the first‐line treatments for CVD. In clinical practice, the extra stents would be used if the curative efficacy of a single stent were unsatisfactory. Aiming to evaluate the therapeutic effect of different PTS schemes, computational fluid dynamics (CFD) simulations on four patients were performed to compare the hemodynamic characteristics of real‐life HD patients after stent placement. The three‐dimensional central vein's models of each patient were built using computational tomography angiography (CTA) images, and idealized models were constructed as contrast. Two inlet velocity modes were imposed to imitate the blood flow rate of healthy and HD patients. The hemodynamic parameters for different patients were investigated, including wall shear stress (WSS), velocity, and helicity. The results showed that the implantation of double stents is able to improve flexibility. When subjected to external force, the double stents have better radial stiffness. This paper evaluated the therapeutic efficacy of stent placement and provided a theoretical basis for CVD intervention in hemodialysis patients.