bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGUJIAN TASIRTU PADAKURU SEBAGAI LAPIS PONDASI AGREGAT KELAS B PADA PERKERASAN JALAN
Authors: Vionita Risma , Sulha Sulha , Adityawan Muhammad Handy Dwi , Minmahddun Anafi 
Published: June 2023

Salah satu sumber material di Sulawesi Tenggara yang cukup potensial untuk digunakan adalah material yang berasal dari Desa Padakuru, Kecamatan Wangi-Wangi, Kabupaten Wakatobi.Dimana material di lokasi tersebut sudah lama dimanfaatkan oleh masyarakat sekitarnya untuk keperluan bahan konstruksi bangunan sipil, sedangkan pemeriksaan mutu material khususnya sebagai bahan timbunan pilihan, dalam hal ini karakteristik dan spesifikasi perlu diketahui.Tujuan dari penelitian ini adalah untuk mengetahui karakteristik dan spesifikasi material sebagai bahan timbunan agregat kelas B jalan dengan mengacu pada spesifikasi yang disyaratkan dengan Standar Nasional Indonesia (SNI) Bidang Bina Marga.Metode ini yang dilakukan adalah melakukan survey dan meninjau luas wilayah, kondisi dan material dari Desa Padakuru, dengan tujuan untuk mengambil data-data literatur yang diperlukan Metode-metode ini dibutuhkan untuk mendapatkan Data Primer seperti data hasil pengujian Laboratoriumdan data sekunder seperti data yang didapat pada jurnal dan hasil penelitian terdahulu.Hasil dari pengujian ini adalah pada pengujian karakteristik analisa saringan tidak memenuhi spesifikasi agregat kelas B berdasarkan Standar Nasional Indonesia (SNI) Bidang Bina Marga, berdasarkan uji keausan, kepadatan dan nilai CBR telah memenuhi spesifikasi dengan nilai keausan 37,45% pengujian kepadatan maksimum 1.692 g/cm3, dan nilai CBR 62%.
TINJAUAN KELAYAKAN PASIR PANTAI LABUAN KECAMATAN WAKORUMBA UTARA SEBAGAI PENYUSUN MORTAR
Authors: Jhosiardan Jhosirdan , Masdiana Masdiana , Balthasar Awill 
Published: June 2023

Pada penelitian ini dipergunakan pasir pantai yang ada dipantai labuan kecamatan wakorumba utara. Penambahan pasir dilakukan untuk memenuhi permintaan masyarakat khususnya masyarakat didaerah pantai. Kuat tekan rata-rata mortar dengan pemakaian pasir pantai untuk bahan bangunan seperti mortar dapat dilakukan dengan komposisi kuat tekan rata-rata mortar tersebut umur 7 hari dan 28 hari masing-masing 6 buah benda uji kubus dengan ukuran 10 x 10 x 10 cm. Hasil kuat tekan mortar dengan menggunakan pasir labuan dengan variansi komposisi 1:4 dan 1:5 yang dicuci dan tidak dicuci. komposisi 1:4 tidak dicuci pada umur 7 hari adalah 43,33 kg/cm² dan 28 hari 71,67 kg/cm² sedangkan dicuci pada umur 7 hari adalah 45 kg/cm² dan 28 hari 81,67 kg/cm². komposis 1:5 tidak dicuci pada umur 7 hari adalah 30 kg/cm² dan 28 hari adalah 65 kg/cm² sedangkan dicuci pada umur 7 hari adalah 43,33 kg/cm² dan 28 hari adalah 71, 67 kg/cm²
PENERAPAN MODEL KOOPERATIF TIPE THE POWER OF TWO UNTUK MENINGKATKAN KERJASAMA DAN HASIL BELAJAR
Authors: Mira Marti 
Published: June 2023

This study is purposed to describe the implementation of cooperative learning the power of two type to improve the studentsâ€™ cooperation, learning outcomes, and the effectivity on the implementation of cooperative learning the power of two type in improving the studentsâ€™ learning outcomes. The study was held by using Classroom Action Research (CAR) and quasi experiment. The subject of the CAR was class XI IPS 3 of SMAN 03 Mukomuko, class XI IPS 2 of SMAN 03 as the experiment class and class XI IPS 1 as the control class. This research used total sample and observation method. Observation sheet were used to measure the teacherâ€™s ability in implementing the learning model and the studentsâ€™ ccooperation and also written test to measure the improvement of the studentâ€™s learning outcomes. The data were gained then analyzed according to the type of the data, the qualitative data were analyzed qualitatively and also the quantitative one that was analyzed by using average formula andÂ dependent and independent sample t-test. Based on the research during three cycles in class XI IPS 3, the result of the analysis showed that the teacherâ€™s ability in implementing the learning model got some improvement during the implementation.Â The studentsâ€™ cooperation and their learning outcomes got some improvements from the first until the third cycle following the teachersâ€™ ability in implementing the cooperative learning model the power of two type. The conclusions of the research were the implementation of cooperative learning model the power of two type was able to improve the studentsâ€™ cooperation and their learning outcomes, the implementation of cooperative learning model the power of two type was more effective to improve the studentsâ€™ learning outcomes than the conventional model on economy subject in class XI IPS of SMAN 03 Mukomuko.
PENINGKATAN HASIL BELAJAR SISWA MELALUI MEDIA DOMINO MATEMATIKA (DOMIKA) PADA SISWA KELAS VIIA SMPN 1 CIKARANG BARAT
Authors: Mumpuni Mumpuni 
Published: June 2023

The improvement of the quality of education can be seen from the achievements achieved by students, while the success of the achievement of mathematics learning results can be seen from the ability of students in solving integer operation problems correctly, although in general, not all students can solve integer operation problems, therefore it is expected that mathematical domino media (DOMIKA) can train students in performing calculation operations so that they are embedded in the carrying nature.Â conscious students. The purpose of this study is to find out the improvement of integer operation learning outcomes through mathematical domino media (DOMIKA) in students of class VII A SMPN 1 Cikarang Barat Bekasi Regency. This research includes a type of classroom action research (PTK), with its main characteristic being repeated actions and the main method is self-reflection aimed at improving learning. PTK is a problem-solving activity characterized by cyclic and reflection that starts from: a) planning, b) actions, c) observing, d) analyzing data/information to decide the extent of the advantages and disadvantages of such actions (reflecting). PTK is characterized by continuous improvement so that research satisfaction is often the benchmark of the cycle. In this first cycle, learning results were obtained with an average score of SMPN 1 Cikarang Barat students in Bekasi Regency of 69 and classically the completeness of student learning results was obtained by 65,625% with a frequency of 21 people out of 32 students present categorized as complete and 34,375% with a frequency of 11 people out of 32 students categorized as incomplete. From these results, it can be stated that the completeness of student learning to the maximum has not been achieved. In cycle II, learning results were obtained with the average score of SMPN 1 Cikarang Barat Students in Bekasi Regency of 80, and classically the percentage of completeness of the learning outcomes of SMPN 1 Cikarang Barat Bekasi Regency reached 93.75% with the number of frequencies of 30 people from 32 students present said to be complete and 6.25% with the number of frequencies of 2 people from 32 students categorized as unfinished. From these results, it can be stated that the application of mathematical domino learning media (DOMIKA) in cycle II is on target.
Comparative microRNA profiling of Trypanosoma cruzi infected human cells
Authors: Rego Natalia , Libisch María Gabriela , Rovira Carlos , Tosar Juan Pablo , Robello Carlos 
Published: June 2023

IntroductionTrypanosoma cruzi, the causative agent of Chagas disease, can infect almost any nucleated cell in the mammalian host. Although previous studies have described the transcriptomic changes that occur in host cells during parasite infection, the understanding of the role of post-transcriptional regulation in this process is limited. MicroRNAs, a class of short non-coding RNAs, are key players in regulating gene expression at the post-transcriptional level, and their involvement in the host-T. cruzi interplay is a growing area of research. However, to our knowledge, there are no comparative studies on the microRNA changes that occur in different cell types in response to T. cruzi infection.Methods and resultsHere we investigated microRNA changes in epithelial cells, cardiomyocytes and macrophages infected with T. cruzi for 24 hours, using small RNA sequencing followed by careful bioinformatics analysis. We show that, although microRNAs are highly cell type-specific, a signature of three microRNAs -miR-146a, miR-708 and miR-1246, emerges as consistently responsive to T. cruzi infection across representative human cell types. T. cruzi lacks canonical microRNA-induced silencing mechanisms and we confirm that it does not produce any small RNA that mimics known host microRNAs. We found that macrophages show a broad response to parasite infection, while microRNA changes in epithelial and cardiomyocytes are modest. Complementary data indicated that cardiomyocyte response may be greater at early time points of infection.ConclusionsOur findings emphasize the significance of considering microRNA changes at the cellular level and complement previous studies conducted at higher organizational levels, such as heart samples. While miR-146a has been previously implicated in T. cruzi infection, similarly to its involvement in many other immunological responses, miR-1246 and miR-708 are demonstrated here for the first time. Given their expression in multiple cell types, we anticipate our work as a starting point for future investigations into their role in the post-transcriptional regulation of T. cruzi infected cells and their potential as biomarkers for Chagas disease.
A machine learning evaluation of patient characteristics associated with prescribing of guideline-directed medical therapy for heart failure
Authors: Kim Rachel , Suresh Krithika , Rosenberg Michael A. , Tan Malinda S. , Malone Daniel C. , Allen Larry A. , Kao David P. , Anderson Heather D. , Tiwari Premanand , Trinkley Katy E. 
Published: June 2023

Introduction/backgroundPatients with heart failure and reduced ejection fraction (HFrEF) are consistently underprescribed guideline-directed medications. Although many barriers to prescribing are known, identification of these barriers has relied on traditional a priori hypotheses or qualitative methods. Machine learning can overcome many limitations of traditional methods to capture complex relationships in data and lead to a more comprehensive understanding of the underpinnings driving underprescribing. Here, we used machine learning methods and routinely available electronic health record data to identify predictors of prescribing.MethodsWe evaluated the predictive performance of machine learning algorithms to predict prescription of four types of medications for adults with HFrEF: angiotensin converting enzyme inhibitor/angiotensin receptor blocker (ACE/ARB), angiotensin receptor-neprilysin inhibitor (ARNI), evidence-based beta blocker (BB), or mineralocorticoid receptor antagonist (MRA). The models with the best predictive performance were used to identify the top 20 characteristics associated with prescribing each medication type. Shapley values were used to provide insight into the importance and direction of the predictor relationships with medication prescribing.ResultsFor 3,832 patients meeting the inclusion criteria, 70% were prescribed an ACE/ARB, 8% an ARNI, 75% a BB, and 40% an MRA. The best-predicting model for each medication type was a random forest (area under the curve: 0.788–0.821; Brier score: 0.063–0.185). Across all medications, top predictors of prescribing included prescription of other evidence-based medications and younger age. Unique to prescribing an ARNI, the top predictors included lack of diagnoses of chronic kidney disease, chronic obstructive pulmonary disease, or hypotension, as well as being in a relationship, nontobacco use, and alcohol use.Discussion/conclusionsWe identified multiple predictors of prescribing for HFrEF medications that are being used to strategically design interventions to address barriers to prescribing and to inform further investigations. The machine learning approach used in this study to identify predictors of suboptimal prescribing can also be used by other health systems to identify and address locally relevant gaps and solutions to prescribing.
The female upper reproductive tract harbors endogenous microbial profiles
Authors: Canha-Gouveia Analuce , Pérez-Prieto Inmaculada , Rodríguez Carmen Martínez , Escamez Teresa , Leonés-Baños Irene , Salas-Espejo Eduardo , Prieto-Sánchez Maria Teresa , Sánchez-Ferrer Maria Luisa , Coy Pilar , Altmäe Signe 
Published: June 2023

IntroductionThe female reproductive tract harbours unique microbial communities (known as microbiota) which have been associated with reproductive functions in health and disease. While endometrial microbiome studies have shown that the uterus possesses higher bacterial diversity and richness compared to the vagina, the knowledge regarding the composition of the Fallopian tubes (FT) is lacking, especially in fertile women without any underlying conditions.MethodsTo address this gap, our study included 19 patients who underwent abdominal hysterectomy for benign uterine pathology, and 5 women who underwent tubal ligation as a permanent contraceptive method at Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA). We analyzed the microbiome of samples collected from the FT and endometrium using 16S rRNA gene sequencing.ResultsOur findings revealed distinct microbiome profiles in the endometrial and FT samples, indicating that the upper reproductive tract harbors an endogenous microbiome. However, these two sites also shared some similarities, with 69% of the detected taxa Being common to both. Interestingly, we identified seventeen bacterial taxa exclusively present in the FT samples, including the genera Enhydrobacter, Granulicatella, Haemophilus, Rhizobium, Alistipes, and Paracoccus, among others. On the other hand, 10 bacterial taxa were only found in the endometrium, including the genera Klebsiella, Olsenella, Oscillibacter and Veillonella (FDR &lt;0.05). Furthermore, our study highlighted the influence of the endometrial collection method on the findings. Samples obtained transcervically showed a dominance of the genus Lactobacillus, which may indicate potential vaginal contamination. In contrast, uterine samples obtained through hysterescopy revealed higher abundance of the genera Acinetobacter, Arthrobacter, Coprococcus, Methylobacterium, Prevotella, Roseburia, Staphylococcus, and Streptococcus.DiscussionAlthough the upper reproductive tract appears to have a low microbial biomass, our results suggest that the endometrial and FT microbiome is unique to each individual. In fact, samples obtained from the same individual showed more microbial similarity between the endometrium and FT compared to samples from different women. Understanding the composition of the female upper reproductive microbiome provides valuable insights into the natural microenvironment where processes such as oocyte fertilization, embryo development and implantation occur. This knowledge can improve in vitro fertilization and embryo culture conditions for the treatment of infertility.
Progestin plus metformin improves outcomes in patients with endometrial hyperplasia and early endometrial cancer more than progestin alone: a meta-analysis
Authors: Shao Fengping , Li Yinguang , Zhao Yunhe 
Published: June 2023

ObjectiveProgestin based therapy is the preferred option for fertility-sparing treatment of reproductive-age women with preserved fertility in endometrial hyperplasia (EH) or early endometrial cancer (EEC). Our objective was to investigate whether metformin could enhance the efficacy of progestin-based therapies by meta-analysis.MethodsWe conducted a meta-analysis of randomized or non-randomized controlled trials by searching of PubMed, Embase, Web of science, and Cochrane database from inception to November 8, 2022. The results of enrolled studies were pooled using meta-analysis to estimate the effect of progestin plus metformin on remission, recurrence, pregnancy rate and live birth rate.ResultsIn the analysis of progestin administered systemically or locally, complete response (CR) was significantly higher in progestin plus metformin versus progestin alone in the EH group (pooled OR 2.08, 95% CI 1.29 to 3.34, P=0.003), in the EEC group (pooled OR 1.86, 95% CI 1.13 to 3.05, P=0.01), but not in EEC and EH group (pooled OR 1.46, 95% CI 0.97 to 2.21, P=0.07). In the analysis of progestin administered systemically, complete response was improved in progestin plus metformin versus progestin alone, in the EH group (pooled OR 2.47, 95% CI 1.45 to 4.21, P=0.0009), in the EEC group (pooled OR 2.09, 95% CI 1.18 to 3.71, P=0.01), and in the EEC and EH group (pooled OR 2.03, 95% CI 1.16 to 3.54, P=0.01). The relapse rates of patients with EEC and EH were not different (pooled OR 0.54, 95% CI 0.24 to 1.20, P=0.13). For obstetric outcomes, the addition of metformin improved pregnancy rate (pooled OR 1.55, 95% CI 0.99 to 2.42, P=0.05), but not live birth rate (pooled OR 0.95, 95% CI 0.45 to 2.01, P=0.89).ConclusionFor fertility-sparing management, compared to progestin alone, the outcomes of patients with endometrial hyperplasia and early endometrial cancer were more improved with progestin plus metformin because progestin plus metformin increases the rate of remission and pregnancy.
Changes in glucose metabolism among recipients with diabetes 1 year after kidney transplant: a multicenter 1-year prospective study
Authors: Bang Jun Bae , Oh Chang-Kwon , Kim Yu Seun , Kim Sung Hoon , Yu Hee Chul , Kim Chan-Duck , Ju Man Ki , So Byung Jun , Lee Sang Ho , Han Sang Youb , Jung Cheol Woong , Kim Joong Kyung , Ahn Hyung Joon , Lee Su Hyung , Jeon Ja Young 
Published: June 2023

BackgroundDiabetes mellitus is a common and crucial metabolic complication in kidney transplantation. It is necessary to analyze the course of glucose metabolism in patients who already have diabetes after receiving a transplant. In this study, we investigated the changes in glucose metabolism after transplantation, and a detailed analysis was performed on some patients whose glycemic status improved.MethodsThe multicenter prospective cohort study was conducted between 1 April 2016 and 31 September 2018. Adult patients (aged 20 to 65 years) who received kidney allografts from living or deceased donors were included. Seventy-four subjects with pre-transplant diabetes were followed up for 1 year after kidney transplantation. Diabetes remission was defined as the results of the oral glucose tolerance test performed one year after transplantation and the presence or absence of diabetes medications. After 1-year post-transplant, 74 recipients were divided into the persistent diabetes group (n = 58) and the remission group (n = 16). Multivariable logistic regression was performed to identify clinical factors associated with diabetes remission.ResultsOf 74 recipients, 16 (21.6%) showed diabetes remission after 1-year post-transplant. The homeostatic model assessment for insulin resistance numerically increased in both groups throughout the first year after transplantation and significantly increased in the persistent diabetes group. The insulinogenic index (IGI30) value significantly increased only in the remission group, and the IGI30 value remained low in the persistent diabetes group. In univariate analysis, younger age, newly diagnosed diabetes before transplantation, low baseline hemoglobin A1c, and high baseline IGI30 were significantly associated with remission of diabetes. After multivariate analysis, only newly diagnosed diabetes before transplantation and IGI30 at baseline were associated with remission of diabetes (34.00 [1.192–969.84], P = 0.039, and 17.625 [1.412–220.001], P = 0.026, respectively).ConclusionIn conclusion, some kidney recipients with pre-transplant diabetes have diabetes remission 1 year after transplantation. Our prospective study revealed that preserved insulin secretory function and newly diagnosed diabetes at the time of kidney transplantation were favorable factors for which glucose metabolism did not worsen or improve 1 year after kidney transplantation.
Panax quinquefolius polysaccharides ameliorate ulcerative colitis in mice induced by dextran sulfate sodium
Authors: Ren Duo-duo , Chen Ke-Cheng , Li Shan-shan , Zhang Yan-ting , Li Zhi-man , Liu Shuang , Sun Yin-shi 
Published: June 2023

This study aimed to investigate the ameliorative effect of the polysaccharides of Panax quinquefolius (WQP) on ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in mice and to explore its mechanism. Male C57BL/6J mice were randomly divided into the control group (C), model group (DSS), positive control mesalazine (100 mg/kg, Y) group, and low (50 mg/kg, L), medium (100 mg/kg, M) and high dose (200 mg/kg, H) of WQP groups. The UC model was induced by free drinking water with 2.5% DSS for 7 days. During the experiment, the general condition of the mice was observed, and the disease activity index (DAI) was scored. The conventional HE staining was used to observe pathological changes in mice’s colon, and the ELISA method was used to detect the levels of interleukin-6 (IL-6), IL-4, IL-8, IL-10, IL-1β and tumor necrosis factor-α (TNF-α) in mice’s colon. The changes in gut microbiota in mice were detected by high-throughput sequencing; the concentration of short-chain fatty acids (SCFAs) was determined by gas chromatography; the expression of related proteins was detected by Western blot. Compared with the DSS group, the WQP group showed a significantly lower DAI score of mice and an alleviated colon tissue injury. In the middle- and high-dose polysaccharides groups, the levels of pro-inflammatory cytokines IL-6, IL-8, IL-1β and TNF-α in the colonic tissue were significantly decreased (P&lt;0.05), while the levels of IL-4 and IL-10 were significantly increased (P&lt;0.05). The 16S rRNA gene sequencing results showed that different doses of WQP could regulate the composition and diversity of gut microbiota and improve its structure. Specifically, at the phylum level, group H showed an increased relative abundance of Bacteroidetes and a decreased relative abundance of Firmicutes compared with the DSS group, which was closer to the case in group C. At the family level, the relative abundance of Rikenellaceae in L, M and H groups increased significantly, close to that in group C. At the genus level, the relative abundance of Bacteroides, Shigella and Oscillospira in the H group increased significantly, while that of Lactobacillus and Prevotella decreased significantly. The high-dose WQP group could significantly increase the contents of acetic acid, propionic acid, butyric acid, and total SCFAs. Different doses of WQP also increased the expression levels of tight junction proteins ZO-1, Occludin and Claudin-1. To sum up, WQP can regulate the gut microbiota structure of UC mice, accelerate the recovery of gut microbiota, and increase the content of Faecal SCFAs and the expression level of tight junction proteins in UC mice. This study can provide new ideas for the treatment and prevention of UC and theoretical references for the application of WQP.