bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing measurement model of green cleaning components for green buildings
Authors: Zainol Nurul Nadiah , Ramli Nur Aqlima , Mohammad Izran Sarrazin , Sukereman Anis Syazwani , Sulaiman Muhammad Azwan 
Published: January 2023

Purpose
This paper aims to assess a measurement model of green cleaning for green buildings in Malaysia. Being one of the contributors to the indoor environmental quality performance, green cleaning has become one of the significant aspects that need to be considered for the well-being and performance of a building, particularly in a green building's operations and maintenance performance. Green buildings without green cleaning practices would hinder the benefits that should be rendered economically, socially and environmentally. However, the absence of clear green cleaning components and requirements in Malaysia has become a motivation to undertake this research.

Design/methodology/approach
A questionnaire survey involving cleaning service providers and green building index (GBI) facilitators was carried out, and the data was then analyzed using partial least squares structural equation modeling. However, this paper will only be focusing on the measurement model assessment.

Findings
Most of the green cleaning components and requirements are acceptable in the model except integrated pest management (in the cleaning procedure component) and hand soaps (in the product and materials component) due to lower factor loadings. Therefore, these two requirements were removed from the measurement model.

Research limitations/implications
Due to a paucity of professionals in the field of green cleaning, the researchers have selected GBI facilitators and cleaning service providers as respondents for this research. The researchers assumed that GBI facilitators are aware of acceptable products and materials for green buildings; meanwhile, cleaning service providers know what is the best cleaning technique and process that helps in achieving cost and resource efficiency. This research also assumed that the green cleaning components identified can be applied to any type of green building, regardless of the differences in needs in each type of building.

Practical implications
This discovery will give the industry, particularly cleaning service providers and green building management teams, a first look at the green cleaning components and requirements.

Originality/value
This paper fulfills the need to study how green cleaning helps in achieving the benefits rendered by green buildings.
Transcriptome‐wide analysis of mRNA N6‐methyladenosine modification in the embryonic development of Spodoptera frugiperda
Authors: Chen Yaqing , Lai Yushan , Liu Runzhou , Yao Lin , Yu Xiao‐Qiang , Wang Xiaoyun 
Published: January 2023

AbstractN6‐methyladenosine (m6A) RNA is the most abundant modification of mRNA, and has been demonstrated in regulating various post‐transcriptional processes. Many studies have shown that m6A methylation plays key roles in sex determination, neuronal functions, and embryonic development in Drosophila and mammals. Here, we analyzed transcriptome‐wide profile of m6A modification in the embryonic development of the destructive agricultural pest Spodoptera frugiperda. We found that the 2 key mRNA m6A methyltransferases SfrMETTL3 and SfrMETTL14 have high homologies with other insects and mammals, suggesting that SfrMETTL3 and SfrMETTL14 may have conserved function among different species. From methylated RNA immunoprecipitation sequencing analysis, we obtained 46 869 m6A peaks representing 8 587 transcripts in the 2‐h embryos after oviposition, and 41 389 m6A peaks representing 9 230 transcripts in the 24‐h embryos. In addition, 5 995 m6A peaks were differentially expressed including 3 752 upregulated and 2243 downregulated peaks. Functional analysis with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes suggested that differentially expressed m6A peak‐modified genes were enriched in cell and organ development between the 2‐ and 24‐h embryos. By conjoint analysis of methylated RNA immunoprecipitation‐seq and RNA‐seq data, we found that RNA m6A methylation may regulate the transcriptional levels of genes related to tissue and organ development from 2‐ to 24‐h embryos. Our study reveals the role of RNA m6A epigenetic regulation in the embryonic development of S. frugiperda, and provides new insights for the embryonic development of insects.
Gut microbial community structure and function of Przewalski's horses varied across reintroduced sites in China
Authors: TANG Liping , YAN Liping , JIA Huiping , XIONG Yu , MA Xinping , CHU Hongjun , SUN Zhicheng , WANG Liang , SHALITANATI Mubalake , LI Kai , HU Defu , ZHANG Dong 
Published: January 2023

AbstractHost‐associated microbiota can significantly impact host fitness. Therefore, naturally occurring variations in microbiota may influence the health and persistence of their hosts. This finding is particularly important in reintroduced animals, as they typically experience habitat changes during translocations. However, little is known about how microbiomes are altered in response to conservation translocation. Here, we accessed the gut microbiome of Przewalski's horse (Equus przewalskii) populations in China from three nature reserves (i.e. Xinjiang Kalamaili Nature Reserve, KNR; Dunhuang Xihu National Nature Reserve, DXNNR; and Anxi Extreme‐arid Desert Nature Reserve, AENR) using 16s rRNA gene and metagenome sequencing. The results showed that the microbial composition and function differed significantly across locations, while a subset of core taxa was consistently present in most of the samples. The abundance of genes encoding microbe‐produced enzymes involved in the metabolism of carbohydrates, especially for glycoside hydrolases, was significantly higher in open‐spaced KNR populations than in more confined AENR individuals. This study offers detailed and significant differential characters related to the microbial community and metabolic pathways in various reintroduced sites of Przewalski's horse, which might provide a basis for future microecological and conservation research on endangered reintroduced animals.
Blood–brain barrier dysfunction promotes astrocyte senescence through albumin‐induced TGFβ signaling activation
Authors: Preininger Marcela K. , Zaytseva Dasha , Lin Jessica May , Kaufer Daniela 
Published: January 2023

AbstractBlood–brain barrier dysfunction (BBBD) and accumulation of senescent astrocytes occur during brain aging and contribute to neuroinflammation and disease. Here, we explored the relationship between these two age‐related events, hypothesizing that chronic hippocampal exposure to the blood‐borne protein serum albumin could induce stress‐induced premature senescence (SIPS) in astrocytes via transforming growth factor beta 1 (TGFβ) signaling. We found that 1 week of albumin exposure significantly increased TGFβ signaling and senescence marker expression in cultured rat hippocampal astrocytes. These changes were preventable by pharmacological inhibition of the type I TGFβ receptor (TGFβR) ALK5. To study these effects in vivo, we utilized an animal model of BBBD in which albumin was continuously infused into the lateral ventricles of adult mice. Consistent with our in vitro results, 1 week of albumin infusion significantly increased TGFβ signaling activation and the burden of senescent astrocytes in hippocampal tissue. Pharmacological inhibition of ALK5 TGFβR or conditional genetic knockdown of astrocytic TGFβR prior to albumin infusion was sufficient to prevent albumin‐induced astrocyte senescence. Together, these results establish a link between TGFβ signaling activation and astrocyte senescence and suggest that prolonged exposure to serum albumin due to BBBD can trigger these phenotypic changes.
A systematic review of the preferences of rural and remote youth for mental health service access: Telehealth versus face‐to‐face consultation
Authors: Mseke Edwin Paul , Jessup Belinda , Barnett Tony 
Published: January 2023

AbstractIntroductionTelehealth has become an increasingly popular method to deliver mental health services to rural and remote youth who are challenged by distance and service availability. However, it remains unclear whether rural and remote youth would prefer to access mental health services via telehealth or by attending services in person.ObjectiveTo systematically review the preferences of rural and remote youth for mental health service access via telehealth versus face‐to‐face consultation.DesignSystematic review of published research papers cited in databases CINAHL, MEDLINE and PubMed databases between 2000 and 2021.FindingsFrom a total of 225 articles identified, four were found to meet inclusion criteria. Three studies reported rural and remote youth preferred to access mental health services face‐to‐face over telehealth. However, three studies also reported youth viewed telehealth as an important adjunct to in person attendance, especially in situations of large travel times.DiscussionAlthough telehealth can facilitate mental health service access, rural and remote youth may prefer to see a mental health professional in person, with telehealth regarded as an adjunct to, not a replacement for, face‐to‐face consultation.ConclusionWhilst rural and remote youth may prefer to access mental health services in person rather than via telehealth, further well designed research is needed to better understand under what circumstances this preference holds true and why. Caution should be exercised in generalising this finding because of the few studies that met the inclusion criteria and different conditions under which youth made their choice to access mental health services.
Selective modulation of estrogen receptor in obese men with androgen deficiency: A systematic review and meta‐analysis
Authors: Tienforti Daniele , Castellini Chiara , Di Giulio Francesca , Totaro Maria , Dalmazio Gilda , Spagnolo Luca , Muselli Mario , Corona Giovanni , Baroni Marco Giorgio , Barbonetti Arcangelo 
Published: January 2023

AbstractBackgroundAlthough selective estrogen receptor modulators have been proposed as a treatment for men with central functional hypogonadism, only a few data have been produced in men with obesity‐related functional androgen deficiency.ObjectiveTo determine whether and to what extent selective estrogen receptor modulators are an effective and safe therapy in men with obesity‐related functional androgen deficiency.Materials and methodsA thorough search of PubMed, Web of Science, Scopus, and Cochrane Library databases was performed to identify studies comparing testosterone levels before and after treatment. Mean differences with 95% coefficient intervals were combined using random effects models. Funnel plot, Egger's test, and trim‐and‐fill analysis were used to assess publication bias.ResultsSeven studies met the inclusion criteria providing information on 292 men with obesity‐related functional androgen deficiency treated with clomiphene citrate (12.5–50 mg daily) or enclomiphene citrate (12.5–25 mg daily) for 1.5–4 months. The pooled estimates indicated a significant increase in testosterone levels both with clomiphene (mean difference: 11.56 nmol/L; 95% coefficient interval: 9.68, 13.43; I2 = 69%, pfor heterogeneity = 0.01) and enclomiphene citrate (mean difference: 7.50 nmol/L; 95% coefficient interval: 6.52, 8.48; I2 = 4%, pfor heterogeneity = 0.37). After the exclusion of one study on severely obese men, who exhibited the highest response rate to clomiphene citrate, the heterogeneity disappeared (mean difference: 10.27 nmol/L; 95% coefficient interval: 9.39, 11.16; I2 = 0%, pfor heterogeneity = 0.66). No publication bias was revealed by Egger's test and trim‐and‐fill analysis. No treatment‐related unexpected findings regarding safety profile were registered.Discussion and conclusionTreatment with clomiphene citrate and enclomiphene citrate may be an effective and safe alternative to testosterone replacement therapy in men with obesity‐related functional androgen deficiency. Further long‐term studies are warranted to define clinical reflections of the selective estrogen receptor modulators‐induced increase in testosterone levels and to better clarify the safety profile.
Furosemide rescues hypercalciuria in familial hypomagnesaemia with hypercalciuria and nephrocalcinosis model
Authors: Kriuchkova Natalia , Breiderhoff Tilman , Müller Dominik , Yilmaz Duygu Elif , Demirci Hasan , Drewell Hoora , Günzel Dorothee , Himmerkus Nina , Bleich Markus , Persson Pontus B. , Mutig Kerim 
Published: January 2023

AbstractAimPerturbed calcium homeostasis limits life expectancy in familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC). This rare disease occurs by loss‐of‐function mutations in CLDN16 or CLDN19 genes, causing impaired paracellular reabsorption of divalent cations along the cortical thick ascending limb (cTAL). Only partial compensation takes place in the ensuing late distal convoluted tubule, connecting tubule, and collecting duct, where the luminal transient receptor potential channel V5 (TRPV5), as well as basolateral plasma membrane calcium ATPase (PMCA) and sodium‐potassium exchanger (NCX1) mediate transcellular Ca2+ reabsorption. The loop diuretic furosemide induces compensatory activation in these distal segments. Normally, furosemide enhances urinary calcium excretion via inhibition of the aforementioned cTAL. As Ca2+ reabsorption in the cTAL is already severely impaired in FHHNC patients, furosemide may alleviate hypercalciuria in this disease by activation of the distal transcellular Ca2+ transport proteins.MethodsCldn16‐deficient mice (Cldn16−/−) served as a FHHNC model. Wild‐type (WT) and Cldn16−/− mice were treated with furosemide (7 days of 40 mg/kg bw) or vehicle. We assessed renal electrolyte handling (metabolic cages) and key divalent transport proteins.ResultsCldn16−/− mice show higher Ca2+ excretion than WT and compensatory stimulation of Cldn2, TRPV5, and NCX1 at baseline. Furosemide reduced hypercalciuria in Cldn16−/− mice and enhanced TRPV5 and PMCA levels in Cldn16−/− but not in WT mice.ConclusionsFurosemide significantly reduces hypercalciuria, likely via upregulation of luminal and basolateral Ca2+ transport systems in the distal nephron and collecting duct in this model for FHHNC.
Uterine rupture in intramural ectopic pregnancy: A case report
Authors: Washio Keiichi , Komatsu Masato , Tomimoto Masako , Uchida Akiko , Sasagawa Yuki , Nishimoto Masashi , Nagamata Satoshi , Yamasaki Yui , Tanimura Kenji , Terai Yoshito 
Published: January 2023

AbstractIntramural pregnancy is a rare form of ectopic pregnancy. It is defined by a gestation within the uterine wall, completely surrounded by myometrium and separated from the uterine cavity and the fallopian tube. We report a rare case of intramural ectopic pregnancy. If a patient has a history of intrauterine surgery or myomectomy, the possibility of intramural pregnancy, although rare, should not be ruled out.
Optimizing adherence to allopurinol for gout: patients' perspectives
Authors: Spragg Jane C. J. , Michael Toni J. F. , Aslani Parisa , Coleshill Matthew J. , Chan Jian S. , Day Richard O. , Stocker Sophie L. 
Published: January 2023

AimsPoor adherence to allopurinol among people with gout contributes to suboptimal gout management. This study sought to understand the facilitators and barriers to allopurinol adherence across the three stages of medication adherence, and patient perspectives on strategies to improve adherence, including self‐monitoring urate concentration.MethodsSemi‐structured interviews were conducted with 26 people with gout, previously or currently taking allopurinol. De‐identified verbatim transcripts were thematically analysed using an inductive and deductive approach.ResultsFacilitators of adherence during allopurinol initiation were motivation to prevent gout flares and trust in the advice of their healthcare professionals (HCPs). Reluctance to commence long‐term medication was a barrier to allopurinol initiation. Believing in the effectiveness and necessity of allopurinol and reminder systems were facilitators of implementation. Barriers to implementation included forgetfulness, gout flares and limited feedback on allopurinol's effectiveness. Patients discontinued therapy when allopurinol was perceived as ineffective or unnecessary. Discontinuation coincided with patients experiencing gout flares while adhering to allopurinol and receiving suboptimal advice about gout management. Patients identified receiving accurate advice from HCPs and regular urate monitoring for feedback on allopurinol's effectiveness as potential strategies to improve adherence. Perceived benefits of self‐monitoring urate as a strategy to promote adherence included the ability to self‐manage gout and make informed decisions about allopurinol therapy with their HCP.ConclusionPatient perceptions of the effectiveness and necessity of allopurinol influenced intentional adherence during medication initiation, implementation and discontinuation. Strategies that inform patients of their urate control and provide accurate medical advice have the potential to improve adherence to allopurinol.
β‐Thalassemia in childhood: Current state of health in a high‐income country
Authors: Donze Caroline , Benoit Audrey , Thuret Isabelle , Faust Cindy ,   NaThalY Network, Gauthier Alexandra , Berbis Julie , Badens Catherine , Brousse Valentine 
Published: January 2023

Summaryβ‐thalassemia is an haemoglobinopathy characterized by a defective synthesis of the β‐globin chain. To assess the current state of health of paediatric patients with β‐thalassemia, data from the French national registry regarding children born between 2005 and 2020 with β‐thalassemia intermedia (TI) or major (TM) were collected. A total of 237 patients (median age 7.1 years at last visit) were analysed, of whom 156 (65.8%) were born in France and 162 (68.4%) had a TM phenotype. The probability of survival for children with TM born in France was 98.3% at 15 years. Fifty‐four (22.8%) children received a haematopoietic stem cell transplant with a success rate of 88.8%. Hepatic and cardiac iron overload monitoring in non‐transplanted patients showed moderate overload in 15.7% (18/115) and 7.1% (7/99) of cases, respectively, while clinical complications were found in only 4 patients with TM (hepatic in 3 cases). At last visit, mean ferritinemia was 1293 ng/ml (±759). Overall, less than 10% of children underwent splenectomy. No significant impact of the disease on growth or academic achievement was observed. Deferasirox was the main first‐line chelator, prescribed in 78.2% of cases, with side effects reported in 11.7% of instances.
Review: Recommendations for male‐friendly counselling with adolescent males: A qualitative systematic literature review
Authors: Boerma Micah , Beel Nathan , Jeffries Carla , Ruse Jesse 
Published: January 2023

BackgroundThere are growing calls to tailor counselling practices for adolescent males, a population reluctant to engage in psychological treatment despite concerning rates of mental illness. The objective of this systematic review (PROSPERO: CRD4202125547) was to collate and synthesise recommendations for individual counselling with adolescent males (12–18 years).MethodThe databases Psychology and Behavioural Science Collection, PsycArticles, PsycINFO, Academic Search Complete, EBSCO eBook Collection, Wiley Science Collection, Taylor and Francis Collection and ProQuest One Academic were searched for articles published between 1995 and November 2021. The quality of evidence was assessed using the JBI critical appraisal checklists, and thematic analysis was employed to synthesise findings across the literature.ResultsA total of 1625 texts were identified, of which 16 met the inclusion criteria. Generated themes included (a) therapist knowledge of masculinity, gender socialisation, and male‐relational styles; (b) necessity of therapists to address masculinity in the therapeutic space; and (c) customising engagement and treatment practices to appeal to adolescent males.ConclusionsThe themes highlighted the unique developmental, and sociocultural considerations practitioners should be aware of when working with young men. Through a multicultural counselling competency framework, masculinity and adolescent male identity are expressions of diverse sociocultural identities that psychological assessment and intervention should ideally be tailored to suit. The findings of the review suggest that empirical research focusing on the experiences of adolescent males receiving psychological treatment is sparse. Further research is needed to inform the development of practicable, gender‐sensitive adaptions to counselling practice for young men.
Update on the controversial identity of cells expressing cnr2 gene in the nervous system
Authors: Grabon Wanda , Bodennec Jacques , Rheims Sylvain , Belmeguenai Amor , Bezin Laurent 
Published: January 2023

AbstractThe function of cannabinoid receptor type 2 (CB2R), mainly expressed by leukocytes, has long been limited to its peripheral immunomodulatory role. However, the use of CB2R‐specific ligands and the availability of CB2R‐Knock Out mice revealed that it could play a functional role in the CNS not only under physiological but also under pathological conditions. A direct effect on the nervous system emerged when CB2R mRNA was detected in neural tissues. However, accurate mapping of CB2R protein expression in the nervous system is still lacking, partly because of the lack of specificity of antibodies available. This review examines the regions and cells of the nervous system where CB2R protein is most likely present by cross‐referencing mRNA and protein data published to date. Of the many antibodies developed to target CB2R, only a few have partially passed specificity tests and detected CB2R in the CNS. Efforts must be continued to support the development of more specific and better validated antibodies in each of the species in which CB2R protein is sought or needs to be quantified.