bluuebunny/crossref_metadata_2025_split huggingface dataset:
VARIETY OF LANGUAGES AND CULTURES OF ACEH CITY
Authors: Harianto II Harianto II , Syukri Syukri 
Published: May 2023

In the local context, the language and culture of the region or elements of locality are always in an important position capable of binding their primordialism, bothinspirit, behavior, social networks, choice of political attitudes, and identity. The dynamics of language and cultural development (local, tribes, and ethnic )are very prominent in their diversity and have strong potential in order to develop and strengthen the unity and unity of the citizens of the Republic of Indonesia. The presence of external factors affects the power of acceptance and self-adjustment to language and culture that comes from outside. Inabsorbing culture and accepting external influences at least results in the occurrence of two aspects:first, outside influences enrich cultural capital and regional languages; and secondly, it can also happen that the opposite is precisely the outside influences that come to reduce, evenpotentially eliminate the existence of regional cultures and languages.
Pembatalan Akta Jual Beli Tanah dan Bangunan di Kelurahan Panjangjiwo, Kecamatan Tenggilis Mejoyo, Kota Surabaya (Studi Putusan Nomor 415/Pdt.G/2017/PN.Sby)
Authors: Riwu Angello Picasho Krusbeek 
Published: May 2023

Penelitian dengan judul “Pembatalan Akta Jual Beli Tanah Dan Bangunan Di Kelurahan Panjangjiwo, Kecamatan Tenggilis Mejoyo, Kota Surabaya (Studi Putusan Nomor 415/Pdt.G/2017/PN.Sby.)” bertujuan untuk mengetahui dan menganalisis pertimbangan-pertimbangan hukum apa saja yang digunakan oleh hakim untuk memutuskan pembatalan Akta Jual Beli dalam putusan Pengadilan Negeri Surabaya Nomor 415/Pdt.G/2017/ PN.Sby. dan apakah surat pernyataan kepemilikan tanah yang sebenarnya dapat menjadi dasar dalam pembatalan Akta Jual Beli. Penelitian ini merupakan penelitian yuridis normatif dengan sumber data utama adalah data sekunder. Data sekunder diperoleh dari studi pustaka yang berupa peraturan perundang-undangan yang merupakan sumber hukum tertulis, melakukan studi putusan, dokumen atau karya ilmiah dan dilengkapi dengan wawancara langsung dengan narasumber sebagai data pendukung. Analisis data dilakukan dengan menggunakan pendekatan kualitatif dan disajikan secara deskriptif. Berdasarkan hasil penelitian dan pembahasan yang telah dilakukan dapat disimpulkan sebagai berikut: (1) Pertimbangan-pertimbangan hukum yang digunakan hakim untuk memutuskan pembatalan Akta Jual Beli dalam putusan Pengadilan Negeri Surabaya Nomor 415/Pdt.G/2017/ PN.Sby. adalah adanya kesesuaian antara dalil dan alat-alat bukti yang diajukan para Tergugat dan tidak ada pembuktian sebaliknya oleh Penggugat. Alat bukti para Tergugat yang berupa kuitansi, rekapan uang penerimaan dan pengeluaran Tergugat, dan Surat Pernyataan almarhum ayah Penggugat dinilai Majelis Hakim saling berkesesuaian satu dengan lainnya dan menguatkan dalil Tergugat dalam gugatan Rekonvensinya. (2) Surat Pernyataan kepemilikan tanah yang sebenarnya dapat menjadi dasar dalam pembatalan suatu Akta Jual Beli dengan syarat surat pernyataan tersebut tidak berdiri sendiri atau dengan kata lain didukung dengan alat-alat bukti lainnya yang dapat berupa alat bukti tertulis dan/atau alat bukti keterangan saksi.
Залишковий уміст металів (As, Cd, Pb, Cu, Fe, Zn) в азотній і хлористоводневій кислотах для атомно-емісійної спектрометрії з індуктивно зв’язаною плазмою
Authors: Брицун В. М. , Череменко А. М. , Кузнецова О. М. , Очеретяна Н. М. , Мелешко Р. А. , Останіна Н. В. 
Published: May 2023

У фармацевтичній галузі метод атомно-емісійної спектрометрії з індуктивно зв'язаною плазмою (ІЗП-АЕС) використовується для встановлення вмісту металів у лікарській сировині, субстанціях і готових лікарських формах, рослинних засобах, дієтичних добавках і в скляних контейнерах. Для випробовувань (пробопідготовки й аналізу) спектрометри ІЗП-АЕС потребують значну кількість неорганічних кислот (зазвичай азотної та хлористоводневої).
Мета дослідження – визначення залишкового вмісту металів – арсену (As), кадмію (Cd), свинцю (Pb), заліза (Fe), міді (Cu), цинку (Zn) у розчинах хлористоводневої й азотної кислот кваліфікації «о. с. ч.» і «ч. д. а.», які застосовуються для випробовувань методом ІЗП-АЕС. Обґрунтування можливостей вико- ристання для аналізів у ІЗП-АЕС розчинів комерційно доступніших кислот кваліфікації «ч. д. а.».
Методом ІЗП-АЕС встановлено, що концентрація домішок (As, Cd, Pb, Сu) у розведених 1 % хло- ристоводневій і 1 % азотній кислотах кваліфікації «ч. д. а.» зазвичай менше межі виявлення приладу. У випадку невеликого надлишку концентрації домішок (Fe, Zn) у холостому, стандартних і випробувальних розчинах він автоматично враховується та компенсується приладом. За необхідності можна застосовувати розчини з меншими концентраціями кислот (0,1–0,5 %).
Отже, розчини розведених 1 % хлористоводневої і 1 % азотної кислот кваліфікації «ч. д. а.» можливо використовувати для визначення кількісного вмісту As, Cd, Pb, Fe, Cu, Zn методом ІЗП-АЕС.
Study of the Radiosensitizing Action of Lithium Ascorbate Under Neutron and Photon Irradiation of Tumor Cells
Authors: Tretyakova M. S. , Drozd A. G. , Belousov M. V. , Brazovskiy K. S. , Larkina M. S. , Krivoshchekov S. V. , Artamonov A. A. , Miloichikova I. A. , Bezmaga A. V. , Bolshakov A. M. , Sukhikh E. S. , Plotnikov E. V. 
Published: May 2023

Introduction. Radioresistance of cancer cells is a serious problem in radiation therapy of tumor diseases. Radiosensitizers make malignant cells more sensitive to radiation and increase the effectiveness of radiation therapy; however, their widespread clinical use is limited by significant side effects. The development and study of new radiosensitizers seems to be an urgent task of modern pharmacology.Aim. The purpose of this work was to study the effectiveness of lithium ascorbate as a radiosensitizer under the influence of photon and neutron radiation in wide dose range.Materials and methods. Evaluation of the biological effect was carried out using the tumor line of prostate cancer PC-3. We used a cyclotron to produce neutron radiation and a Cobalt-60 source to produce gamma radiation.Results and discussion. We have proved an increase in the cytotoxic effect with the combined use of different types of ionizing radiation and lithium ascorbate. The resistance of the prostate cancer line to gamma radiation at an absorbed dose of 0.5–3.0 Gy was revealed. It was shown that tumor cells of prostate cancer are more sensitive to the effects of the study drug in minimal concentrations in combination with neutron irradiation compared to gamma radiation in the same absorbed dose. The main mechanism of the radiosensitizing action of lithium ascorbate is the local induction of oxidative stress, which synergistically enhances the action of ionizing radiation.Conclusion. The combination of lithium ascorbate with neutron radiation leads to a more pronounced resulting cytotoxic effect. An increase in the concentration of lithium ascorbate led to the pro-oxidative action with an increase in the damaging effect on cells.
Regulation of the Launch of Orphan Drugs on the Market of the Eurasian Economic Union as a Mechanism to Increase the Availability of Treatment for Rare Diseases (Review)
Authors: Foteeva A. V. , Koneva N. A. , Beloglazova O. S. , Rostova N. B. 
Published: May 2023

Introduction. Providing high-quality, effective and safe drugs intended for the treatment of rare (orphan) diseases among the population of the Member States of the Union is one of the most significant and promising development vectors for manufacturers-developers. Ensuring the availability of medicines (MP) for patients suffering from rare diseases should be regulated by state incentives for the development and launch of orphan drugs on the market by domestic manufacturers through updating and timely updating of regulatory legal acts in the field of drug registration, as well as providing benefits when initiating the registration process.Text. The article assessed the possibilities and prospects for the introduction of orphan drugs into circulation within the framework of the Eurasian Economic Union for domestic manufacturers.Conclusion. A review of the possibilities and prospects for launching orphan drugs for domestic manufacturers indicates the need to develop regulatory and legal regulation of aspects of pharmaceutical development in order to increase the availability of treatment for patients with rare diseases, both at the level of the Russian Federation and within the legal framework of the Eurasian Economic Space.
Molecular Docking: Methodological Approaches of Risk Assessment
Authors: Taldaev A. Kh. , Nikitin I. D. , Terekhov R. P. , Selivanova I. A. 
Published: May 2023

Introduction. Computational chemistry methods and, particularly, the noncovalent molecular docking are increasingly implemented into the practice of drug development. Previously, a risk management of potential biases did not applied for this relatively young research instrument.Aim. The study objective was to design the risk assessment system for noncovalent molecular docking.Materials and methods. The development of bias risk assessment system was based on the world's leading practices in noncovalent molecular docking.Results and discussions. As a result of the deductive analysis of the molecular docking process, bias domains were identified and a risk-based algorithm was proposed, which was tested on a sample of articles obtained during a systematic review. A tendency to frequent limited provision of information on the methodology of the computational experiment, as well as on the application of practices proven to lead to irrelevant results of molecular docking, has been revealed.Conclusion. The data obtained cannot be extrapolated to all studies that refer to the results of molecular modeling. However, through the proposed risk-based algorithm, the attention of researchers is focused on assessing the quality of such publications. We hope that the developed tool for bias risk assessment in noncovalent molecular docking will be finalized and eventually put into practice. It will possibly reduce the share of low-quality work in the field of drug development at the earliest stages.
Influence of Excipients and Pressing Force on the Impurity Content of N-(4-aminobenzoyl)-L-glutamic Acid in Folic Acid Drugs During Storage
Authors: Obraztsova N. A. , Samsonov A. A. , Kovtunenko M. A. , Shmeleva V. N. , Golubeva N. A. 
Published: May 2023

Introduction. Excipients, impurities contained in them, and sorbed water are one of the reasons for degradation of the active pharmaceutical substance (API). Excipients effect should be especially evaluated for moisture-sensitive APIs. Folic acid (FA) is an important vitamin for humans. It hydrolyze in water under the action of UV irradiation and main decomposition product is N-(p-aminobenzoyl)glutamic acid (impurity A). We found an increase in the content of impurity A during FA film-coated tablets storage in PVC-film and aluminum foil packaging in the absence of UV irradiation.Aim. Investigate the effect of excipients and parameters of the production process on the content of impurity A during storage of FA drugs.Materials and methods. The FA tablets containing 1.0 mg of API produced by direct compression technology were the objects of study. The pressing force (PF) was varied from 5 to 15 kN.Results and discussion. We found that content of impurity A in tablets containing 93.0 % lactose monohydrate and obtained with PF above 10 kN exceeded limit value during storage for 300 days. Probably lactose simultaneously acts both as a source of free water and as a catalyst for FA hydrolysis. Since the interaction of lactose and FA occurs in the solid phase, pressing accelerates hydrolysis by increasing the contact area of substances and the mobility of water molecules.Conclusion. We found that lactose monohydrate probably is the main cause of FA hydrolysis in drugs. Independently of the mechanism of its action, an increase in the PF above 10 kN leads to an increase in the rate of FA hydrolysis. This is due to an increase in the mobility of water molecules and the contact area between the excipient and API. We have selected the optimum pressure range (5–10 kN) for tablet mix containing lactose monohydrate and FA.
Application of Scanning Electron Microscopy to Study Morphological and Anatomical Features of Sea Buckthorn Leaves
Authors: Kovaleva N. A. , Trineeva O. V. 
Published: May 2023

Introduction. Scanning electron microscopy is a modern method that allows us to study not only the morphological features of objects, but also to conduct micro-X-ray structural analysis. Currently, the method is being actively introduced into the study of biological objects (including plant ones). Sea buckthorn (Hippophaë rhamnoides L.) leaves are a non-pharmacopoeial type of medicinal plant raw materials. Further study of the morphology, anatomy and phytochemical composition of leaves can contribute to the production of new, including combined, medicines, which will require the development of a pharmacopoeia article for this medicinal plant raw material.Aim. The aim of the study was to study the morphological and anatomical features of sea buckthorn leaves by scanning electron microscopy.Materials and methods. The object of the study was dried whole leaves of sea buckthorn (Hippophaë rhamnoides L.), collected in the Voronezh region in 2021 during the period of mass fruit maturity. To carry out the study by scanning electron microscopy, pieces of leaves were previously sprayed with gold on an automatic spraying unit Q150R ES (Quorum Technologies Ltd., United Kingdom) to increase conductivity. Micrographs were obtained using an electron microscope JSM-6510LV (JEOL Ltd., Japan).Results and their discussion. The morphology and some features of the anatomical structure of sea buckthorn leaves were studied and the main microdiagnostic signs (surface character, types of trichomes, the presence of stomata) were clarified. The content of elements (silicon, potassium, aluminum, carbon and calcium) was determined during the microrentgenostructural analysis. Micrographs of pollen grains of the plant were obtained, the presence of the element iron in them was established.Conclusion. For the first time, the method of scanning electron microscopy was used to study the morphological and anatomical features of sea buckthorn leaves. The main diagnostic signs of leaves and their location have been clarified. It has been established that carbon predominates in the composition of the raw material elements, and calcium also accumulates. The accumulation of aluminum, silicon and potassium in numerous hairs densely covering the upper, and especially the lower, surfaces of the leaf blade is assumed. The morphology of the surface of pollen grains of sea buckthorn, having a spherical shape with a spiny shell, has been established. Pollen grains, in addition to carbon, are characterized by the accumulation of iron and silicon.
Method for Testing of Drugs Belonging to Substrates and Inhibitors of the Transporter Protein BCRP on Caco-2 Cells
Authors: Tranova Yu. S. , Slepnev A. A. , Chernykh I. V. , Shchulkin A. V. , Mylnikov P. Yu. , Popova N. M. , Povetko M. I. , Yakusheva E. N. 
Published: May 2023

Introduction. Breast cancer resistance protein (BCRP) is an efflux membrane transporter that controls the pharmacokinetics of a large number of drugs. Its activity may change when taking some endo- and exogenous substances, thus making it a link in drug interactions.Aim. The aim of the study was to develop a method for testing of drugs for belonging to BCRP substrates and inhibitors in vitro.Materials and methods. The work was performed on Caco-2 cells overexpressing BCRP, the cultivation was performed in a transwell-system consisting of the apical and basolateral chambers. Cells were seeded at the bottom of the apical chamber, which is a semipermeable membrane. Primarily, the transport of BCRP substrates: methotrexate, mitoxantrone and quercetin was evaluated in the concentration range of 1, 5, 10, and 50 μM in the direction from the basal chamber to the apical one (Papp b-a) and in the opposite direction (Papp a-b). The ratio Papp b-a / Papp a-b more than «2» characterizes the participation of transporter proteins in the transcellular transport of substances. To confirm the participation of BCRP in their transport the experiment was carried out with the addition of a transporter inhibitor, reserpine, to the transport medium at a concentration of 50 μM. The concentration of substrates in the chambers was analyzed by HPLC-MS/MS.Results and their discussion. The addition of methotrexate (1 μM), mitoxantrone (1 μM), and quercetin (1–10 μM) to both the apical or basolateral chambers of the transwell-system, their content in the recipient chamber was not detected. When methotrexate concentration became 5 μM the Papp b-a / Papp a-b ratio was 3.38 ± 0.08, which indicates the involvement of transporters in its transfer. The addition of methotrexate to the donor chamber at concentrations of 10 and 50 μM, Papp b-a / Papp a-b decreased to values below «2». At mitoxantrone concentration of 5 μM Papp b-a / Papp a-b was 2.72 ± 0.16. An increase in the concentration to 10 μM led to an increase in Papp b-a / Papp a-b to 6.18 ± 0.08. With a substance content of 50 μM the indicator decreased but remained above the value «2». In the quercetin concentration of 50 microns, Papp b-a / Papp was below "2". Reserpine reduced Papp b-a / Papp a-b of methotrexate by 3.31 times (p = 0.0002), which indicates the elimination of asymmetry in the transport of the substance. At a mitoxantrone concentration of 10 microns, reserpine reduced its Papp b-a / Papp a-b by 3.36 times (p < 0.0001). The results indicate the participation of BCRP in the control of the transfer of both substances through the cellular monolayer.Conclusion. A method of testing drugs belonging to BCRP substrates and inhibitors using methotrexate (5 μM) and mitoxantrone (10 μM) as marker substrates and reserpine (50 μM) as inhibitor was developed and tested on Caco-2 cells.
Development and Validation of a Method for the Quantitative Determination of Etoricoxib in Liquid Dosage Form
Authors: Amandusova A. Kh. , Kovalenko A. E. , Morozov A. V. , Savelyeva K. R. , Batalova T. L. , Ostapyuk O. A. , Persanova L. V. , Andreevicheva T. Yu. , Beniashvili A. G. , Shestakov V. N. , Polyakov S. V. 
Published: May 2023

Introduction. Etoricoxib is a selective cyclooxygenase (COX-2) inhibitor used for the treatment of acute pain and has anti-inflammatory and analgesic efficacy. Etoricoxib causes fewer complications compared to other non-steroidal anti-inflammatory drugs (NSAIDs). FSI "SID and GP" has developed an ophthalmic liquid dosage form based on etoricoxib. This article proposes a method for determining the content of etoricoxib in a liquid dosage form by high performance liquid chromatography with UV detection.Aim. Development and validation of a method for the quantitative determination of etoricoxib in liquid dosage form.Materials and methods. Eye drops with a concentration of the active substance etoricoxib of 0.05 % were used for the analysis, a standard sample of etoricoxib (Kekule Pharma Limited, India, series ACE-3 WS001/15). Chromatographic separation performed on an Agilent 1220 Infinity II LC high performance liquid chromatograph (Agilent Technologies, USA) equipped with a gradient pump, a column thermostat, and a diode array detector. The analysis carried out on a Kromasil C8 column 250 × 4.6 mm, using acetonitrile and 0.05 M buffer solution of potassium dihydrogen phosphate pH = 4.2 as a mobile phase in a ratio of 46 : 54. The analysis time was 15 minutes at a detection wavelength of 235 nm.Results and discussion. A method for the quantitative determination of etoricoxib in a liquid dosage form developed and validated according to the following indicators: specificity, linearity, accuracy, range, intermediate precision, repeatability.Conclusion. According to the results of validation tests, all of the listed parameters meet the acceptance criteria. The proposed method characterize by high efficiency and specificity.
The Role of Principal Leadership in Improving Ethical Techers Works of Islamic Education
Authors: Hernawan Hernawan , Subandi Subandi , Tukiran Tukiran 
Published: May 2023

This study aims to describe the principal's leadership role in increasing teacher morale, describe the principal's efforts to improve teacher work discipline, and describe the strategies employed by the principal to improve a good work ethic at IT Al Asror Middle School, Sekampung Case District in East Lampung District, Province Lampung. This study uses a type of qualitative research. The approach used is phenomenology. Data sources were taken from 4 people as informants. Data collection procedures include interview techniques, observation, and documentation studies. The results of research findings at IT Al Asror Middle School are: (1) The leadership role of the principal is to improve the teacher's work ethic in building student character, more importantly the principal provides motivation with a high spirit of intention to carry out his duties and responsibilities as a leader (2) Efforts carried out by the principal to improve the work ethic are compiling school programs, vision, mission and goals as well as evaluating the performance of teachers and employees, timely attendance, preparing lessons according to the lesson plan and the methods used in PAIKEM learning (3) the principal's strategy in improving the teacher's work ethic is to provide appropriate salaries, provide comfortable, clean and disciplined facilities in the school environment. The conclusion of this study is the leadership role of the school principal in improving the teacher's work ethic in building student character as a motivator, educator and motivator in providing good morale. tall and as a leader must create discipline, comfort, and high security in order to maintain the implementation of quality work in the school environment
Keywords: Principal Leadership, Ethical Techers Works, Role of Principal Leadership
Joint denoising method of seismic velocity signal and acceleration signals based on independent component analysis
Authors: Zhang Guangde , Zhang Huaibang , You Li , Yang Yuyong , Zhou Huailai , Zhang Bohan , Chen Wujin , Liu Liyuan 
Published: May 2023

The signal-to-noise ratio (SNR) of seismic data is the key to seismic data processing, and it also directly affects interpretation of seismic data results. The conventional denoising method, independent variable analysis, uses adjacent traces for processing. However, this method has problems, such as the destruction of effective signals. The widespread use of velocity and acceleration geophones in seismic exploration makes it possible to obtain different types of signals from the same geological target, which is fundamental to the joint denoising of these two types of signals. In this study, we propose a joint denoising method using seismic velocity and acceleration signals. This method selects the same trace of velocity and acceleration signal for Independent Component Analysis (ICA) to obtain the independent initial effective signal and separation noise. Subsequently, the obtained effective signal and noise are used as the prior information for a Kalman filter, and the final joint denoising results are obtained. This method combines the advantages of low-frequency seismic velocity signals and high-frequency and high-resolution acceleration signals. Simultaneously, this method overcomes the problem of inconsistent stratigraphic reflection caused by the large spacing between adjacent traces, and improves the SNR of the seismic data. In a model data test and in field data from a work area in the Shengli Oilfield, the method increases the dominate frequency of the signal from 20 to 40 Hz. The time resolution was increased from 8.5 to 6.8 ms. The test results showed that the joint denoising method based on seismic velocity and acceleration signals can better improve the dominate frequency and time resolution of actual seismic data.