bluuebunny/crossref_metadata_2025_split huggingface dataset:
EDEN (Etude Désescalade sEmiNome): Prospective therapeutic de-escalation and miRNA-M371 biomarker evaluation phase II study for stage IIa/IIb < 3 cm seminomas.
Authors: Vinceneux Armelle , Pasquier David , Blanc Ellen , Attignon Valéry , Blanchard Pierre , Flechon Aude 
Published: March 2023

TPS434 Background: At diagnosis, 10 to 15% of testicular pure seminomas have a stage II defined by the presence of retroperitoneal lymph node metastases. The optimal choice of treatment modalities are associated with excellent efficacy but also acute and late toxicities. De-escalating treatment for seminoma patients with stage IIb, IIc and III and good prognosis according to IGCCCG (International Germ Cell Cancer Collaborative Group) based on negative FDG-PET (Fluorodeoxyglucose Positron Emission Tomography) after 2 cycles of EP (etoposide, cisplatine) chemotherapy seems feasible and safe according to SEMITEP cohort 2 results (Loriot Y, and al GETUG SEMITEP Trial: Eur Urol. 2022 Aug;82(2):172-179). Serum levels of microRNA (miR)-371a-3p (miRNA-M371) have been significantly associated with clinical stage and response to treatment in testicular germ cell tumors, with sensitivity and specificity higher than those of classic markers. The aim of the study NCT05529251 is to propose a new therapeutic approach for the stages IIa/IIb. Methods: This phase II, multicenter, prospective, randomized, non-comparative, de-escalation study will include patient with primary testicular seminomatous germ cell tumor with stage IIa/IIb < 3 cm in largest diameter seminoma, histologically proved after orchiectomy and good prognosis according to IGCCCG and LDH (Lactate DesHydogenase) < 2.5 x Upper Limit of Normal (ULN). They must have progressive disease and no prior treatment with radiotherapy or chemotherapy. In case of negative week-3 (after 1 EP cycle) PET-scan, patients will be randomized according to 2 arms ARM A: Boost of radiotherapy 20 to 30 Gray (Gy); ARM B Carboplatin AUC7 chemotherapy. In case of positive week-3 PET-scan: 3 courses of EP chemotherapy (ARM C). Primary outcome will include progression-free rate at 36 months. Secondary Outcome Measures will be serum level of miRNA M371, correlation with response to treatments and PET scan results, overall survival (OS), quality of life and tolerance to treatment. Blood samples (miRNA-M371) will be collected at screening, at the time of randomization before second cycle of chemotherapy or radiotherapy, at the end of treatment and at relapse. Enrollment has started in October 2022. A total of 90 patients will be included in the interventional study, leading to approximately 60 patients with negative FDG-PET randomized. Clinical trial information: NCT05529251 .
SPADE: Design of a real-world observational study of avelumab first-line (1L) maintenance in advanced urothelial carcinoma (UC) in the Asia-Pacific (APAC) region.
Authors: Su Po-Jung , Park Se Hoon , Tsai Yu Chieh , Kim Miso , Wu Wen-Jeng , Gao Seasea , Shin Sang Joon 
Published: March 2023

TPS577 Background: UC is a common cancer, with >200,000 new cases reported in the APAC region in 2020. In the global phase 3 JAVELIN Bladder 100 trial, avelumab 1L maintenance + best supportive care (BSC) significantly prolonged overall survival (OS) and progression-free survival (PFS) vs BSC alone in patients with advanced UC that had not progressed with 1L platinum-containing chemotherapy (median OS, 23.8 vs 15.0 months [p=0.0036]; median PFS, 5.5 vs 2.1 months [p<0.0001]), leading to regulatory approvals worldwide and incorporation into international treatment guidelines with level 1 evidence. The objectives of the SPADE noninterventional study are to evaluate real-world patient characteristics, treatment patterns, patient-reported outcomes (PROs) and treatment outcomes with avelumab maintenance administered in patients with advanced UC without disease progression after 1L platinum-based chemotherapy in the APAC region. Methods: SPADE is a multicenter, prospective, observational study ongoing in Australia, Hong Kong, India, Japan, Republic of Korea, Singapore, Taiwan, and other countries. Overall, 286 patients with unresectable locally advanced or metastatic (stage IV) measurable UC of any histology that has not progressed with 1L platinum-containing chemotherapy, for whom avelumab 1L maintenance therapy is planned, will be enrolled. All patients will receive avelumab 800 mg intravenously every 2 weeks (or per local marketing authorization) and will be followed up for 12 months or until avelumab is discontinued. The decision to start avelumab treatment should be made in advance by the treating physician and per local clinical practice. Data collected will include patient demographics (ECOG performance status, renal function, history of UC, primary tumor location, location of metastases, and prior therapy), treatment details for 1L platinum-based chemotherapy (regimen, cycles, and response per RECIST), treatment details for avelumab 1L maintenance (interval from end of chemotherapy until initiation, duration of avelumab treatment, and planned subsequent treatment), and treatment outcomes with avelumab 1L maintenance (6- and 12-month OS and health-related quality of life). Data sources will include medical records collected during routine clinical care. Data for baseline treatment patterns will be summarized using descriptive statistics. OS will be analyzed using the Kaplan-Meier method. Health-related quality of life, including changes over time, will be measured using the EQ-5D-5L and National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy Bladder Symptom Index (NCCN/FACT FBISI-18) questionnaires. An interim analysis is planned after ~30% of patients have been enrolled.
Scaling the Detail: Woolfian Proportions
Authors: Spitzer Jennifer 
Published: March 2023

AbstractVirginia Woolf seems to have agreed with Georg Lukács about the static quality of details in turn-of-the century fiction: she too condemned the pictorialism that transformed human subjects and their environments into “still lives.” Her own details are anything but static: they are always in motion, zooming in and zooming out, demanding close observation while also enlarging the frame to the global impact of war or the marginalization of women. Woolf uses details dynamically to move between material objects and human minds, and also to move across scales, and thus produces a specifically narrative theory of the detail. This is also a political theory: the fact that she places large and small side by side, often in the same sentence, speaks to her commitment to tracing connections between the particular and the abstract, the mundane and the mystical, the internal world of thoughts and feelings and the external world of actions.
Mechanistic studies in Drosophila and chicken give new insights into functions of DVL1 in dominant Robinow syndrome
Authors: Gignac Sarah J. , MacCharles Katja R. , Fu Katherine , Bonaparte Kywana , Akarsu Gamze , Barrett Thalia W. , Verheyen Esther M. , Richman Joy M. 
Published: March 2023

ABSTRACT
The study of rare genetic diseases provides valuable insights into human gene function. The autosomal dominant or autosomal recessive forms of Robinow syndrome are genetically heterogeneous, and the common theme is that all the mutations lie in genes in Wnt signaling pathways. Cases diagnosed with Robinow syndrome do survive to adulthood with distinct skeletal phenotypes, including limb shortening and craniofacial abnormalities. Here, we focus on mutations in dishevelled 1 (DVL1), an intracellular adaptor protein that is required for both canonical (β-catenin-dependent) or non-canonical (requiring small GTPases and JNK) Wnt signaling. We expressed human wild-type DVL1 or DVL1 variants alongside the endogenous genome of chicken and Drosophila. This design is strategically suited to test for functional differences between mutant and wild-type human proteins in relevant developmental contexts. The expression of variant forms of DVL1 produced a major disorganization of cartilage and Drosophila wing morphology compared to expression of wild-type DVL1. Moreover, the variants caused a loss of canonical and gain of non-canonical Wnt signaling in several assays. Our data point to future therapies that might correct the levels of Wnt signaling, thus improving skeletal growth.
Predictors of face mask use during the COVID-19 pandemic in Indonesia: Application of the health belief model, psychological distress and health motivation
Authors: Wulandari Devi , Purba Fredrick Dermawan , Alfikalia Alfikalia , Kertamuda Fatchiah Ekowati , Rahmania Tia , Sabrina Olivia Ayu , Hidayah Kurnia Nurul , Fatimah Syarifah 
Published: March 2023

Background: High infection rates of COVID-19 in Indonesia require attention, especially transmission and prevention behaviors. One way to lower infection rates is the use of face masks. However, people's adherence to its usage when in public is still low. This necessitates the exploration of predictors of the use of masks to increase community compliance. This study further aims to investigate the predictors of face mask use by applying the Health Belief Model, anxiety, stress, depression, and health motivation. Methods: A total of 255 respondents from Jakarta, Bandung, Tangerang, and Banten filled out an online questionnaire. Furthermore, hierarchical multiple regression was used to detect predictors associated with face mask use. Results: The results showed that the high perceived benefits and health motivation were higher in individuals who used a face mask when in public, while those who have high perceived barriers likely do not use masks. The respondent's level of psychological distress, including depression, anxiety, and stress were not associated with face mask use. Conclusions: Therefore, these findings highlight the importance of personal appraisal regarding COVID-19 and its prevention behaviors. Comfortable mask design, and emphasizing the benefits of using masks in the community improve compliance.
Evaluation of serum VEGF-A and interleukin 6 as predictors of angiogenesis during peri-implantation period assessed by Transvaginal Doppler Ultrasonography amongst women of prior reproductive failure: a cross-sectional analytical study.
Authors: Pratapan Nair Priya , Shrivastava Deepti 
Published: March 2023

Background: Infertility is a wide spectrum of disorder affecting many couples and is defined as the inability of a couple to achieve pregnancy. A series of investigations are required to know the reason behind infertility, yet a small percentage (08-37%) of couples exist, in which no obvious cause is delineated. Different hormones, growth factors and interleukins are responsible for successful ovulation, implantation and further growth of embryo. Endometrial receptivity is an important predictor of the outcome of implantation and further growth of embryo. Methods: The study would be conducted in a tertiary care centre over a period of two years from July 2022 till July 2024 on non-pregnant unexplained infertile women (63) who will undergo In vitro Fertilisation and Embryo Transfer (IVF-ET) in the following cycle and the result will be compared with the fertile women (21) with same demographic features. The levels of serum Vascular Endothelial Growth factor–A, interleukin-6 will be measured on day 21 of the menstrual cycle in both the group, simultaneously, transvaginal ultrasonography and doppler findings will be measured in both groups to see for endometrial receptivity. The values will be compared for any significance. A new Scoring system will be generated of these three parameters PREDICGIO scoring system after pilot study on ten patients. The values of Serum VEGF-A, IL6 and Doppler findings will be compared between fertile and infertile group to see for significant difference. Conclusion: The current study helps in determining the suboptimal vasculogenesis and angiogenesis in women with failure in reproduction. It will also help to a great extent in managing patients of reproductive failure with immunomodulator drugs thus providing external angiogenic factors to help in conceiving and carrying pregnancy till term.
Using general-purpose integer programming software to generate bounded solutions for the multiple knapsack problem: a guide for or practitioners
Authors: Shively-Ertas Emre , Lu Yun , Song Myung , Vasko Francis 
Published: March 2023

An NP-Hard combinatorial optimization problem that has significant industrial applications is the Multiple Knapsack Problem. If approximate solution approaches are used to solve the Multiple Knapsack Problem there are no guarantees on solution quality and exact solution approaches can be intricate and challenging to implement. This article demonstrates the iterative use of general-purpose integer programming software (Gurobi) to generate solutions for test problems that are available in the literature. Using the software package Gurobi on a standard PC, we generate in a relatively straightforward manner solutions to these problems in an average of less than a minute that are guaranteed to be within 0.16% of the optimum. This algorithm, called the Simple Sequential Increasing Tolerance (SSIT) algorithm, iteratively increases tolerances in Gurobi to generate a solution that is guaranteed to be close to the optimum in a short time. This solution strategy generates bounded solutions in a timely manner without requiring the coding of a problem-specific algorithm. This approach is attractive to management for solving industrial problems because it is both cost and time effective and guarantees the quality of the generated solutions. Finally, comparing SSIT results for 480 large multiple knapsack problem instances to results using published multiple knapsack problem algorithms demonstrates that SSIT outperforms these specialized algorithms.
Development of machine-learning algorithms for 90-day and one-year mortality prediction in the elderly with femoral neck fractures based on the HEALTH and FAITH trials
Authors: Dijkstra Hidde , Oosterhoff Jacobien H. F. , van de Kuit Anouk , IJpma Frank F. A. , Schwab Joseph H. , Poolman Rudolf W. , Sprague Sheila , Bzovsky Sofia , Bhandari Mohit , Swiontkowski Marc , Schemitsch Emil H. , Doornberg Job N. , Hendrickx Laurent A. M. 
Published: March 2023

AimsTo develop prediction models using machine-learning (ML) algorithms for 90-day and one-year mortality prediction in femoral neck fracture (FNF) patients aged 50 years or older based on the Hip fracture Evaluation with Alternatives of Total Hip arthroplasty versus Hemiarthroplasty (HEALTH) and Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trials.MethodsThis study included 2,388 patients from the HEALTH and FAITH trials, with 90-day and one-year mortality proportions of 3.0% (71/2,388) and 6.4% (153/2,388), respectively. The mean age was 75.9 years (SD 10.8) and 65.9% of patients (1,574/2,388) were female. The algorithms included patient and injury characteristics. Six algorithms were developed, internally validated and evaluated across discrimination (c-statistic; discriminative ability between those with risk of mortality and those without), calibration (observed outcome compared to the predicted probability), and the Brier score (composite of discrimination and calibration).ResultsThe developed algorithms distinguished between patients at high and low risk for 90-day and one-year mortality. The penalized logistic regression algorithm had the best performance metrics for both 90-day (c-statistic 0.80, calibration slope 0.95, calibration intercept -0.06, and Brier score 0.039) and one-year (c-statistic 0.76, calibration slope 0.86, calibration intercept -0.20, and Brier score 0.074) mortality prediction in the hold-out set.ConclusionUsing high-quality data, the ML-based prediction models accurately predicted 90-day and one-year mortality in patients aged 50 years or older with a FNF. The final models must be externally validated to assess generalizability to other populations, and prospectively evaluated in the process of shared decision-making.Cite this article: Bone Jt Open 2023;4(3):168–181.
Time dependency and unique etiology of barotrauma in COVID-19: A retrospective cohort study with landmark analysis and pathological approach
Authors: Kabuto Takafumi , Seo Ryutaro , Miyakoshi Chisato , Shimizu Yuri , Shima Yusuke , Yamashita Daisuke , Hara Shigeo , Hirabayashi Ryosuke , Tomii Keisuke , Takayama Masakazu , Tetsumoto Keisuke , Saito Masao , Hamakawa Hiroshi , Suki Bela , Takahashi Yutaka 
Published: March 2023

Background
Barotrauma frequently occurs in coronavirus disease 2019. Previous studies have reported barotrauma to be a mortality-risk factor; however, its time-dependent nature and pathophysiology are not elucidated. To investigate the time-dependent characteristics and the etiology of coronavirus disease 2019-related-barotrauma.

Methods and findings
We retrospectively reviewed intubated patients with coronavirus disease 2019 from March 2020 to May 2021. We compared the 90-day survival between the barotrauma and non-barotrauma groups and performed landmark analyses on days 7, 14, 21, and 28. Barotrauma within seven days before the landmark was defined as the exposure. Additionally, we evaluated surgically treated cases of coronavirus disease 2019-related pneumothorax.
We included 192 patients. Barotrauma developed in 44 patients (22.9%). The barotrauma group’s 90-day survival rate was significantly worse (47.7% vs. 82.4%, p < 0.001). In the 7-day landmark analysis, there was no significant difference (75.0% vs. 75.7%, p = 0.79). Contrastingly, in the 14-, 21-, and 28-day landmark analyses, the barotrauma group’s survival rates were significantly worse (14-day: 41.7% vs. 69.1%, p = 0.044; 21-day: 16.7% vs. 62.5%, p = 0.014; 28-day: 20.0% vs. 66.7%, p = 0.018). Pathological examination revealed a subpleural hematoma and pulmonary cyst with heterogenous lung inflammation.

Conclusions
Barotrauma was a poor prognostic factor for coronavirus disease 2019, especially in the late phase. Heterogenous inflammation may be a key finding in its mechanism. Barotrauma is a potentially important sign of lung destruction.
Design and functional preliminary investigation of recombinant antigen EgG1Y162–EgG1Y162 against Echinococcus granulosus
Authors: Zhou Yanxia , Zhao Shangqi , Li Yanmin , Yu Mingkai , Zheng Jia , Gong Qiaoqiao , Cao Chunbao , Ding Jianbing , Zhou Xiaotao 
Published: March 2023

Abstract
In the early stage, our research group cloned Echinococcus granulosus-specific antigen, EgG1Y162, from protoscolex and adult worms of E. granulosus. In order to enhance the immunogenicity of the vaccine, we prepared a recombinant vaccine by tandemly linking EgG1Y162, splicing the protein and linker at the gene level. This approach is expected to improve the immunogenicity of the vaccine by enhancing the molecular weight of the protein and increasing the antigenic epitopes. Bioinformatics was used to predict the physicochemical properties, transmembrane domain, protein structure, and T-/B-cell antigenic epitope of different recombinant proteins, EgG1Y162-linker-EgG1Y162. Finally, the linker sequence, “GGGGSGGG,” which had the least influence on the migration of recombinant protein T/B epitope and can fold normally in series with EgG1Y162, was selected to design the recombinant vaccine. The plasmid was produced using genetic engineering techniques, and the recombinant protein, EGG1Y162-GGGGSGGG-EgG1Y162, was induced to be expressed and purified. EgG1Y162-GGGGSGGG-EgG1Y162 was identified to be correctly expressed with 100% specificity. Compared with EgG1Y162, EgG1Y162-GGGGSGGG-EgG1Y162 was more likely to promote dendritic cell maturation. EgG1Y162-GGGGSGGG-EgG1Y162 was speculated to have the potential to improve antigen immunogenicity by increasing the molecular weight and antigenic epitope.
Effect of pressurized hot water extraction on the resistance of Scots pine sapwood against mould fungi
Authors: Kyyrö Suvi , Altgen Michael , Belt Tiina , Seppäläinen Hanna , Brischke Christian , Heinze Petra , Militz Holger , Rautkari Lauri 
Published: March 2023

Abstract
The effects of pressurized hot water extraction (HWE) treatment on the mould resistance of wood have not been extensively investigated yet. The activity of the mould fungi is dependent on the availability of nutrients. Therefore, the soluble degradation products produced during HWE treatment could affect the wood’s susceptibility to mould growth. Scots pine (Pinus sylvestris L.) sapwood specimens were treated with HWE at 140 °C for 1–5 h. Afterwards, the degradation products were either removed via leaching or the wood was dried without applying the leaching procedure. The surface layer (1.5 mm) was removed from half of the leached and non-leached specimens. The resistance of the specimens against mould growth was tested in an incubation chamber. HWE treated wood showed a higher susceptibility to mould growth when it was neither leached nor subjected to surface removal. The susceptibility of wood to mould fungi depended on the availability of hemicellulose-based degradation products produced during HWE treatment. These degradation products were removable via a leaching procedure, but also by removing the outermost layer of the wood. The results show the relevance of removing HWE degradation products located on the wood surface in improving resistance against mould growth.
Addressing loneliness in the workplace through human-robot interaction
Authors: Busch Melina , Lindermayer Tim , Schuster Klara , Zhang Jonas , von Terzi Pia 
Published: March 2023

Abstract
New work has been a topic for a few years now and the COVID-19 pandemic has brought this trend more into focus, i.e., working remotely became more popular. However, besides various advantages, there is the risk of loneliness in employees, which can negatively affect their work performance and mental health. Research in different domains suggests that social robots could reduce loneliness. Since we were interested in whether and how such findings are transferable to the office context, we developed and tested a concept for a social office robot. More specifically, we first conducted a cultural probes study with white-collar workers to gain information about workplace loneliness and its drivers. Second, we explored design possibilities for a social office robot in a focus group. Based on the results, we created a concrete concept, Luca, which we finally evaluated and optimized with the help of interviews with participants from various industries. The present work contributes to HRI research and practice, e.g., by providing design recommendations for the implementation of a social office robot. Future research could investigate the effectiveness of a social office robot intervention in field studies. Next to implications for research and practice, potential limitations are discussed.