bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain self-management plus activity tracking and nurse-led support in adults with chronic low back pain: feasibility and acceptability of the problem-solving pain to enhance living well (PROPEL) intervention
Authors: Xu Wanli , Zhang Yiming , Wang Zequan , Dorsey Susan G , Starkweather Angela , Kim Kyounghae 
Published: June 2023

Abstract
Background
Chronic low back pain can lead to individual suffering, high medical expenditures, and impaired social well-being. Although the role of physical activity in pain management is well established, the underlying mechanisms of biological and clinical outcomes are unknown. This study aimed to assess the feasibility and acceptability of a pain self-management intervention, Problem-Solving Pain to Enhance Living Well, which employs wearable activity tracking technology and nurse consultations for people with chronic low back pain.

Methods
This one-arm longitudinal study recruited 40 adults aged 18–60 years with chronic low back pain. Over 12 weeks, participants watched 10 short video modules, wore activity trackers, and participated in nurse consultations every 2 weeks. At baseline and the 12-week follow-up, they completed study questionnaires, quantitative sensory testing, and blood sample collection.

Results
Forty participants were recruited, and their mean age was 29.8. Thirty-two participants completed the survey questionnaire, quantitative sensory testing, Fitbit activity tracker, and bi-weekly nurse consultation, and 25 completed the evaluation of biological markers. The overall satisfaction with the Problem-Solving Pain to Enhance Living Well video modules, nurse consultations, and Fitbit in pain management was rated as excellent. No adverse events were reported. Between the baseline and 12-week follow-up, there was a significant decrease in pain intensity and interference and an increase in the warm detection threshold at the pain site.

Conclusions
Despite concerns about the participant burden due to multidimensional assessment and intensive education, the feasibility of the Problem-Solving Pain to Enhance Living Well intervention was favorable. Technology-based self-management interventions can offer personalized strategies by integrating pain phenotypes, genetic markers, and physical activity types affecting pain conditions.

Trial registration
This pilot study was registered with ClinicalTrials.gov [NCT03637998, August 20, 2018]. The first participant was enrolled on September 21, 2018.
Applying multidimensional computerized adaptive testing to the MSQOL-54: a simulation study
Authors: Giordano Andrea , Testa Silvia , Bassi Marta , Cilia Sabina , Bertolotto Antonio , Quartuccio Maria Esmeralda , Pietrolongo Erika , Falautano Monica , Grobberio Monica , Niccolai Claudia , Allegri Beatrice , Viterbo Rosa Gemma , Confalonieri Paolo , Giovannetti Ambra Mara , Cocco Eleonora , Grasso Maria Grazia , Lugaresi Alessandra , Ferriani Elisa , Nocentini Ugo , Zaffaroni Mauro , De Livera Alysha , Jelinek George , Solari Alessandra , Rosato Rosalba 
Published: June 2023

AbstractBackgroundThe Multiple Sclerosis Quality of Life-54 (MSQOL-54) is one of the most commonly-used MS-specific health-related quality of life (HRQOL) measures. It is a multidimensional, MS-specific HRQOL inventory, which includes the generic SF-36 core items, supplemented with 18 MS-targeted items. Availability of an adaptive short version providing immediate item scoring may improve instrument usability and validity. However, multidimensional computerized adaptive testing (MCAT) has not been previously applied to MSQOL-54 items. We thus aimed to apply MCAT to the MSQOL-54 and assess its performance.MethodsResponses from a large international sample of 3669 MS patients were assessed. We calibrated 52 (of the 54) items using bifactor graded response model (10 group factors and one general HRQOL factor). Then, eight simulations were run with different termination criteria: standard errors (SE) for the general factor and group factors set to different values, and change in factor estimates from one item to the next set at < 0.01 for both the general and the group factors. Performance of the MCAT was assessed by the number of administered items, root mean square difference (RMSD), and correlation.ResultsEight items were removed due to local dependency. The simulation with SE set to 0.32 (general factor), and no SE thresholds (group factors) provided satisfactory performance: the median number of administered items was 24, RMSD was 0.32, and correlation was 0.94.ConclusionsCompared to the full-length MSQOL-54, the simulated MCAT required fewer items without losing precision for the general HRQOL factor. Further work is needed to add/integrate/revise MSQOL-54 items in order to make the calibration and MCAT performance efficient also on group factors, so that the MCAT version may be used in clinical practice and research.
Adipose tissue-derived human mesenchymal stromal cells can better suppress complement lysis, engraft and inhibit acute graft-versus-host disease in mice
Authors: Wu Stanley Chun Ming , Zhu Manyu , Chik Stanley C. C. , Kwok Maxwell , Javed Asif , Law Laalaa , Chan Shing , Boheler Kenneth R. , Liu Yin Ping , Chan Godfrey Chi Fung , Poon Ellen Ngar-Yun 
Published: June 2023

Abstract
Background
Acute graft-versus-host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). Transplantation of immunosuppressive human mesenchymal stromal cells (hMSCs) can protect against aGvHD post-HSCT; however, their efficacy is limited by poor engraftment and survival. Moreover, infused MSCs can be damaged by activated complement, yet strategies to minimise complement injury of hMSCs and improve their survival are limited.

Methods
Human MSCs were derived from bone marrow (BM), adipose tissue (AT) and umbilical cord (UC). In vitro immunomodulatory potential was determined by co-culture experiments between hMSCs and immune cells implicated in aGvHD disease progression. BM-, AT- and UC-hMSCs were tested for their abilities to protect aGvHD in a mouse model of this disease. Survival and clinical symptoms were monitored, and target tissues of aGvHD were examined by histopathology and qPCR. Transplanted cell survival was evaluated by cell tracing and by qPCR. The transcriptome of BM-, AT- and UC-hMSCs was profiled by RNA-sequencing. Focused experiments were performed to compare the expression of complement inhibitors and the abilities of hMSCs to resist complement lysis.

Results
Human MSCs derived from three tissues divergently protected against aGvHD in vivo. AT-hMSCs preferentially suppressed complement in vitro and in vivo, resisted complement lysis and survived better after transplantation when compared to BM- and UC-hMSCs. AT-hMSCs also prolonged survival and improved the symptoms and pathological features of aGvHD. We found that complement-decay accelerating factor (CD55), an inhibitor of complement, is elevated in AT-hMSCs and contributed to reduced complement activation. We further report that atorvastatin and erlotinib could upregulate CD55 and suppress complement in all three types of hMSCs.

Conclusion
CD55, by suppressing complement, contributes to the improved protection of AT-hMSCs against aGvHD. The use of AT-hMSCs or the upregulation of CD55 by small molecules thus represents promising new strategies to promote hMSC survival to improve the efficacy of transplantation therapy. As complement injury is a barrier to all types of hMSC therapy, our findings are of broad significance to enhance the use of hMSCs for the treatment of a wide range of disorders.
Production of ginsenoside compound K from American ginseng extract by fed-batch culture of Aspergillus tubingensis
Authors: Song Woo-Seok , Shin Kyung-Chul , Oh Deok-Kun 
Published: June 2023

AbstractCompound K (C-K), one of the most bioactive ginsenoside, is produced by hydrolyzing the glycoside moieties of protopanaxadiol (PPD)-type glycosylated ginsenosides in the ginseng extract. To enhance the biotransformation of PPD-type ginsenosides in American ginseng extract (AGE) into C-K, the optimization of the feed type, concentration, and period for the carbon source sucrose and the reactant AGE was performed in fed-batch fermentation of Aspergillus tubingensis using a fermenter. The concentration (3.94 g/L) and productivity (27.4 mg/L/h) of C-K after feed optimization in fed-batch fermentation increased 3.1-fold compared to those (1.29 g/L and 8.96 mg/L/h) in batch fermentation, and a molar conversion of 100% was achieved. To the best of our knowledge, this is the first trial of fed-batch fermentation to convert ginseng extract into deglycosylated ginsenoside and the highest reported C-K concentration and productivity using ginseng extract via fermentation. After ethanol and resin treatments, C-K solids with purities of 59% and 96% were obtained from the fermentation broth as food- and pharmaceutical-grade products, respectively.
Graphical Abstract
High-resolution shape models of Phobos and Deimos from stereophotoclinometry
Authors: Ernst Carolyn M. , Daly R. Terik , Gaskell Robert W. , Barnouin Olivier S. , Nair Hari , Hyatt Benjamin A. , Al Asad Manar M. , Hoch Kielan K. W. 
Published: June 2023

AbstractWe created high-resolution shape models of Phobos and Deimos using stereophotoclinometry and united images from Viking Orbiter, Phobos 2, Mars Global Surveyor, Mars Express, and Mars Reconnaissance Orbiter into a single coregistered collection. The best-fit ellipsoid to the Phobos model has radii of (12.95 ± 0.04) km × (11.30 ± 0.04) km × (9.16 ± 0.03) km, with an average radius of (11.08 ± 0.04) km. The best-fit ellipsoid to the Deimos model has radii of (8.04 ± 0.08) km × (5.89 ± 0.06) km × (5.11 ± 0.05) km with an average radius of (6.27 ± 0.07) km. The new shape models offer substantial improvements in resolution over existing shape models, while remaining globally consistent with them. The Phobos model resolves grooves, craters, and other surface features ~ 100 m in size across the entire surface. The Deimos model is the first to resolve geological surface features. These models, associated data products, and a searchable, coregistered collection of images across six spacecraft are publicly available in the Small Body Mapping Tool, and will be archived with the NASA Planetary Data System. These products enable an array of future studies to advance the understanding of Phobos and Deimos, facilitate coregistration of other past and future datasets, and set the stage for planning and operating future missions to the moons, including the upcoming Martian Moons eXploration (MMX) mission.
Graphical Abstract
Estimation of weak and strong ground motions based on diffuse field concept for earthquake for steps 2 and 3 of blind prediction exercise
Authors: Nagashima Fumiaki , Kawase Hiroshi , Nakano Kenichi , Ito Eri 
Published: June 2023

AbstractFor the accurate prediction of earthquake ground motions, the investigation of three elements in its process, namely the source, path, and site effects, is crucial, and their accuracy and reliability should be evaluated. The Committee of the 6th Effect of Surface Geology on Seismic Motion Symposium conducted a blind prediction exercise to investigate the accuracy and reliability of estimating the subsurface velocity structure related to the site effect and for predicting weak and strong ground motions. We participated in a blind prediction exercise and estimated the weak and strong ground motions that occurred during the 2016 Kumamoto earthquake sequence. First, the velocity structures at a target site KUMA and our reference site EEB were identified based on the diffuse field concept for earthquake (DFCe). The identified velocity structures at KUMA and EEB reproduced the observed horizontal-to-vertical spectral ratios of earthquakes well and were considered to be able to reproduce the horizontal and vertical site amplification factors based on DFCe. Second, the incident waves at the seismic bedrock of EEB were estimated. For weak and strong ground motions, the spectral amplitudes of the three components of the incident waves were estimated from the vertical motions observed on the surface at EEB assuming the generation of a diffuse field for a single earthquake record and the linearity of the vertical amplification factor, even during strong shaking. Finally, the ground motions on the surface at KUMA were estimated using the incident waves estimated at the seismic bedrock, the inverted velocity structure, and the dynamic deformation characteristics distributed by the organizer of the blind prediction exercise for shallow soil sediments. The spectral amplitudes of the estimated strong ground motions were smaller at around 1 Hz and larger at around 10 Hz than the observed ones. However, the estimated overall spectral levels of all components corresponded to the observed ones. Although several parameters require further research, such as the damping factor of soil sediments, we have shown that the proposed method can estimate the overall seismic ground motions at a target site in the blind.Graphical Abstract
Colonic oxygen microbubbles augment systemic oxygenation and CO2 removal in a porcine smoke inhalation model of severe hypoxia
Authors: Mountford Paul A. , Leiphrakpam Premila D. , Weber Hannah R. , McCain Andrea , Scribner Robert M. , Scribner Robert T. , Duarte Ernesto M. , Chen Jie , Noe Dragana , Borden Mark A. , Buesing Keely L. 
Published: June 2023

AbstractInhalation injury can lead to pulmonary complications resulting in the development of respiratory distress and severe hypoxia. Respiratory distress is one of the major causes of death in critically ill patients with a reported mortality rate of up to 45%. The present study focuses on the effect of oxygen microbubble (OMB) infusion via the colon in a porcine model of smoke inhalation-induced lung injury. Juvenile female Duroc pigs (n = 6 colonic OMB, n = 6 no treatment) ranging from 39 to 51 kg in weight were exposed to smoke under general anesthesia for 2 h. Animals developed severe hypoxia 48 h after smoke inhalation as reflected by reduction in SpO2 to 66.3 ± 13.1% and PaO2 to 45.3 ± 7.6 mmHg, as well as bilateral diffuse infiltrates demonstrated on chest X-ray. Colonic OMB infusion (75–100 mL/kg dose) resulted in significant improvements in systemic oxygenation as demonstrated by an increase in PaO2 of 13.2 ± 4.7 mmHg and SpO2 of 15.2 ± 10.0% out to 2.5 h, compared to no-treatment control animals that experienced a decline in PaO2 of 8.2 ± 7.9 mmHg and SpO2 of 12.9 ± 18.7% over the same timeframe. Likewise, colonic OMB decreased PaCO2 and PmvCO2 by 19.7 ± 7.6 mmHg and 7.6 ± 6.7 mmHg, respectively, compared to controls that experienced increases in PaCO2 and PmvCO2 of 17.9 ± 11.7 mmHg and 18.3 ± 11.2 mmHg. We conclude that colonic delivery of OMB therapy has potential to treat patients experiencing severe hypoxemic respiratory failure.
Acquired diaphragmatic hernia following a peritoneal biopsy for gastric cancer dissemination in the diaphragm: a case report
Authors: Endo Kazuya , Hara Kentaro , Nemoto Koichi , Goto Nozomi , Nishina Kazuhisa , Funatsu Nozomi , Takagi Maki , Ueno Kohdai , Onodera Atsushi , Cho Haruhiko 
Published: June 2023

Abstract
Background
Acute diaphragmatic hernia is a life-threatening condition caused by prolapse of an abdominal organ into the thoracic cavity through a defect in the diaphragm. We present herein a case of acquired diaphragmatic hernia following a peritoneal biopsy for gastric cancer dissemination in the diaphragm.

Case presentation
A 72-year-old, female patient presented with a complaint of acute abdomen 10 months after receiving a diagnosis of stage IV gastric cancer with peritoneal dissemination based on peritoneal biopsy findings during staging laparoscopy. Computed tomography demonstrated herniation of the small intestine into the thoracic cavity. Emergency surgery was performed, and a full-thickness diaphragmatic defect was found intraoperatively at the same location as the previous, peritoneal biopsy. The incarcerated small intestine was atraumatically repositioned into the abdominal cavity, and the defect was closed laparoscopically using an absorbable barbed suture.

Conclusions
Although complications of staging laparoscopy are extremely rare, excising disseminated nodules from the diaphragm carries the risk of diaphragmatic hernia. For this reason, avoiding excision is desirable unless a diaphragmatic biopsy is needed.
Total pancreatectomy with remnant stomach preservation in a patient with a history of proximal gastrectomy and interposed jejunal reconstruction with right gastroepiploic conduit preservation: a case report
Authors: Matsumura Masaru , Kobayashi Masahiro , Okubo Satoshi , Haruta Shusuke , Koyama Rikako , Uruga Hironori , Shindoh Junichi , Imamura Tsunao , Takazawa Yutaka , Hashimoto Masaji 
Published: June 2023

Abstract
Background
Pancreatic head resection following proximal gastrectomy jeopardizes the blood flow of the remnant stomach owing to right gastroepiploic conduit sacrifice, thereby necessitating total gastrectomy. However, owing to its high invasiveness, concomitant remnant total gastrectomy with pancreatectomy should be avoided as much as possible. Herein, we describe our experience of total pancreatectomy with right gastroepiploic conduit preservation in a patient with a history of proximal gastrectomy and reconstruction by jejunum interposition.

Case presentation
A 78-year-old woman with a history of gastric cancer was followed up at our institute for multiple intraductal papillary mucinous neoplasm, and main pancreatic duct stricture in the pancreatic head was newly detected. The cystic lesion was extended to the pancreatic body. Proximal gastrectomy and reconstruction by jejunal interposition were previously performed, and the mesenteric stalk of the interposed jejunum was approached through the retrocolic route. We planned total pancreatectomy with right gastroepiploic conduit preservation. Following adhesiolysis, the interposed jejunum and its mesentery lying in front of the pancreas were isolated. The arterial arcade from the common hepatic artery to the right gastroepiploic artery was detached from the pancreas. Furthermore, the right gastroepiploic vein was isolated from the pancreas. The pancreatic body and tail were pulled up in front of the remnant stomach, and the splenic artery and vein were resected. The pancreatic body and tail were pulled out to the right side, and the pancreatic head was divided from the pancreatic nerve plexus to the portal vein. The jejunal limb for entero-biliary anastomosis was passed through the hole behind the superior mesenteric artery and vein, and gastrointestinal anastomosis using the antecolic route and Braun anastomosis were performed.

Conclusions
To avoid remnant total gastrectomy, right gastroepiploic conduit preservation is an optional procedure for pancreatic head resection in patients who have undergone proximal gastrectomy with reconstruction by jejunal interposition.
Stressful life events and passive behavioral patterns in women with major depressive disorder: a mixed method analysis nested in a clinical trial
Authors: Hemanny Curt , Moura Isabela , Pimenta Mello Martha Amaral , Figueiredo André Macedo , Demarzo Marcelo , De-Oliveira Irismar Reis 
Published: June 2023

Abstract
Background
Women are more vulnerable to presenting with major depressive disorder (MDD) as they seem more sensitive to stressful life events (SLE). Few studies describe the effect of SLE on the development of avoidant/passive behavioral patterns (PBP) of MDD. Understanding the relationship between SLE and PBP is essential for the clinical management of MDD. Here, we aim (1) to describe and categorize the perceptions about SLE, emotional experience, and PBP in women with MDD and (2) to discuss the PBP according to evolutionary and behavioral processes. This mixed-method study, including qualitative and quantitative analyses, was nested in a clinical trial with 76 patients. We selected a sample of 18 female patients, randomized to behavioral activation therapy (BAT). In the first sessions, we interviewed the patients about SLE, emotional experience, and PBP perceived during their current depressive episode. The reports were submitted to content analysis and categorized under similar themes. We performed bivariate Spearman correlations to test the strenghts of associations between depressive symptoms (HAM-D), anxiety symptoms (BAI), disability (SDS), and cognitive distortions (CD-Quest).

Results
In our sample, the most frequent SLE were romantic relationship problems and family problems. The patients most reported emotional experiences were sadness, discouragement, and anxiety. The most common PBP categories were getting isolated, stopping doing activities, and ruminating.

Conclusions
Women frequently perceive interpersonal, family, and affective problems as triggers of depressive episodes. The most common passive patterns include isolation, stopping doing activities, and ruminations. The evolutionary functions of PBP are to keep the organism passive, avoiding energy expenditure, and risk exposure in the face of a chronically stressful environment with few opportunities for reward.
Serum hydrogen sulphide levels in acute asthmatic children: a case control study
Authors: Abdallah Abd El Megied Mohamed , Motey Mohammad Abdel Fattah Abdel , Amen Ahmed Salama 
Published: June 2023

Abstract
Background
It’s thought that respiratory epithelium-produced reduced hydrogen sulphide (H2S) plays a role in the pathophysiology of acute asthma. In this case–control research, blood H2S levels were examined between matched acutely asthmatic children and non-asthmatic controls. The grade of acute asthma, vital signs and absolute eosinophilic count in the asthmatic children were likewise associated with the blood H2S level.

Methods
Forty Egyptian asthmatic children had visited the emergency room and forty age- and sex-matched non-asthmatic controls had their blood H2S levels measured using enzyme-linked immunosorbent assay (ELISA).

Results
The serum H2S in the two groups did not differ statistically significantly. Serum H2S and respiratory rate showed a moderately significant inverse connection (r = -0.325, p = 0.041). However, serum H2S and other clinical or laboratory variables exhibited no meaningful relationships. Patients' absolute and percentage eosinophil counts were considerably higher than healthy controls. Serum H2S exhibited a sensitivity of 50% and a specificity of 32.5% for identifying children with acute asthma from non-asthmatic children.

Conclusion
Children with asthma and those without asthma had similar serum H2S levels. It has a lousy relationship with respiratory rate. It is indicated that it is an inadequate screening and diagnostic tool since it has low sensitivity (50%) and specificity (32.5%) in differentiating acute asthmatic children.