bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compressive response and energy absorption of foam-filled aluminum honeycomb composite: experiments and simulation ​
Authors: Fathi Mohammad , Sameezadeh Mahmood , Vaseghi Majid 
Published: June 2023

Abstract
In this study, the effect of foam-filling pattern on the compressive response and energy absorption capacity of the aluminum honeycomb composite have been investigated. An aluminum honeycomb core and a polyurethane foam were used to produce foam-filled honeycomb panels in three patterns with the same volume fraction of the foam. Experimental quasi-static compression tests were performed in the in-plane direction. Numerical analysis based on the conducted tests was also performed by ABAQUS finite element software in similar laboratory conditions to verify the accuracy of the experiments. The results show that the polyurethane-filling pattern is effective in the compressive behavior of the honeycomb core due to the creation and changing the shear bands, the length of the path deflection and compressive force distribution. At an angle of 30 to 35 degrees, the honeycomb materials deform in the in-plane direction, forming shear bands with a greater strain. However, by using the optimized foam pattern - alternating pattern - in addition to enhancing the honeycomb's compressive strength and energy absorption capacity by 490 percent and 800 percent, respectively, the foam usage rate can be reduced up to 35% compared to the full foam mode, resulting in lower cost.
Adapting blockchain’s proof-of-work mechanism for multiple traveling salesmen problem optimization
Authors: Sabry Nareman , Shabana Bahaa , Handosa Mohamed , Rashad M. Z. 
Published: June 2023

Abstract
The blockchain network uses a Proof-of-Work (PoW) mechanism to validate transactions and keep the blockchain growth safe against tampering, but it is hugely energy-consuming with no benefit to the peer-to-peer network participants. In this paper, we propose a blockchain network for distributing products to different locations based on the use of the Proof of Useful Work (PoUW) mechanism, in which miners use computing resources to optimize the travelling salesman problem (TSP) as an alternative to solving mathematical problems that represent the basis of the traditional PoW mechanism to get a new block. According to this proposed blockchain, it not only receives and securely stores the distribution locations but also improves the paths for salesmen when travelling between different locations. This strategy aims to take advantage of the miners’ efforts to minimize the distance travelled by salesmen by applying the clustering technique and computing the shortest path by Guided Local Search (GLS) for each cluster at the same time. According to the tested results on TSP-LIB instances, the used technique works efficiently with an average of 0.08 compared to the rest of the meta-heuristics, and the proposed architecture reduced total distances with an average of 0.025.
The role of seasonal surface heating on the chaotic origins of ENSO spring predictability barrier
Authors: Yu Dakuan , Hang Chaoxun , Zhou Meng 
Published: June 2023

Abstract
The El Niño-Southern Oscillation (ENSO) is a climate phenomenon characterized by the periodic fluctuation of Sea Surface Temperature (SST) anomaly in the tropical Pacific Ocean, which has a significant impact on global weather and climate patterns. However, predicting ENSO evolution several seasons in advance is challenging due to the Spring Predictability Barrier (SPB) phenomenon, which refers to the reduced accuracy of ENSO forecasts during the spring. By investigating the nonlinear dynamic characteristics of ENSO systems simulated by a box model, we found that the strong atmospheric heating process in spring is likely responsible for the occurrence of the SPB. Specifically, the strong atmospheric heating causes the increase in SST within the eastern tropical Pacific in spring, which in turn raises the chaotic degree of ENSO systems. As the chaotic degree of ENSO systems increases, initial errors in the forecast model grow more rapidly, resulting in the SPB phenomenon.
Ten-Step Minimally Invasive Slalom Unilateral Laminotomy for Bilateral Decompression (sULBD) with Navigation
Authors: Adelhoefer Siegfried J , Berger Jessica , Mykolajtchuk Catherine , Gujral Jaskeerat , Boadi Blake I , Fiani Brian , Hartl Roger 
Published: June 2023

Abstract
Background
Unilateral laminotomy for bilateral decompression (ULBD) is a MIS surgical technique that offers safe and effective decompression of lumbar spinal stenosis (LSS) with a long-term resolution of symptoms. Advantages over conventional open laminectomy include reduced expected blood loss, muscle damage, mechanical instability, and less postoperative pain. The slalom technique combined with navigation is used in multi-segmental LSS to improve the workflow and effectiveness of the procedure.
Methods
We outline ten technical steps to achieve a slalom unilateral laminotomy for bilateral decompression (sULBD) with navigation. In a retrospective case series, we included patients with multi-segmental LSS operated in our institution using the sULBD between 2020-2022. The primary outcome was a reduction in pain measured by Visual Analogue Scale (VAS) for back pain and leg pain and Oswestry Disability Index (ODI).
Results
In our case series (N=7), all patients reported resolution of initial symptoms on an average follow-up of 20.71 ± 9 months. The average operative time and length of hospital stay were 196.14 minutes and 1.67 days, respectively. On average, VAS (back pain) was 4.71 pre-operatively and 1.50 on long-term follow-up of an average of 19.05 months. VAS (leg pain) decreased from 4.33 to 1.21. ODI was reported as 33 % pre-operatively and 12 % on long-term follow-up.
Conclusion
The sULBD with navigation is a safe and effective MIS surgical procedure and achieves the resolution of symptoms in patients presenting with multi-segmental LSS. Herein, we demonstrate the ten key steps required to perform the sULBD technique. Compared to the standard sULBD technique, the incorporation of navigation provides anatomic localization without exposure to radiation to staff for a higher safety profile along with a fast and efficient workflow.
Effect of smoking status on clinical outcomes after reperfusion therapy for acute ischemic stroke
Authors: Irie Fumi , Matsuo Ryu , Mezuki Satomi , Wakisaka Yoshinobu , Kamouchi Masahiro , Kitazono Takanari , Ago Tetsuro 
Published: June 2023

Abstract

Although smoking has detrimental effects on the cardiovascular system, some studies have reported better clinical outcomes in smokers than in nonsmokers after thrombolysis for ischemic stroke, known as the smoking paradox. This study aimed to examine the smoking paradox in patients with ischemic stroke receiving reperfusion therapy. Data were collected from a multicenter hospital-based acute stroke registry in Fukuoka, Japan. We divided the 1,148 study patients into current and noncurrent smokers. The association between smoking and clinical outcomes, including neurological improvement (≥ 4-point decrease in the National Institutes of Health Stroke Scale during hospitalization or 0 points at discharge) and good functional outcomes (modified Rankin Scale score of 0–2) at 3 months, was evaluated by logistic regression analysis and propensity score-matched analysis. Of the participants, 231 (20.1%) were current smokers. After adjusting for potential confounders, the odds ratios (ORs) of favorable outcomes were not significantly increased in current smokers (OR: 0.85, 95% confidence interval [CI]: 0.60–1.22 for neurological improvement; OR: 0.95, 95% CI: 0.65–1.38 for good functional outcome). No significant association was found in the propensity score-matched cohorts either. Given that current smoking was not associated with better outcomes after reperfusion therapy, smoking cessation is strongly recommended.
Validated stability indicating reversed-phase high-performance liquid chromatography (RP-HPLC) for the estimation of FINERENONE in Pharmaceutical tablet dosage form
Authors: Imran Shendu Jaman , Kini Suvarna G , Kumar Vijaya , Sonawane Bhushan , Chaudhari Jagdish , Warde Sayali 
Published: June 2023

Abstract
An RP-HPLC method was developed and validated for the estimation of Finerenone in the tablet dosage form. Stability indicating nature of the method was established by conducting forced degradation studies Niacinamide was used as an Internal Standard (I.S) to make the method more accurate and precise. The separation was achieved on Hemochrom C18 (25m, 4.6mm, 5µm) analytical column (250 mm × 4.6 mm i.d.5µm) using 0.1% Trifluoro acetic Acid: Acetonitrile (70:30) as mobile phase and at a flow rate of 1.0 mL/min. Detection of Finerenone was carried out at 252nm. The total chromatographic analysis time per sample was about 10.0 min with Finerenone eluting at a retention time of about 4.17 min. The method was validated for accuracy, precision, specificity, linearity, and sensitivity. Validation studies demonstrated that the method is simple, specific, rapid, reliable, and reproducible. The standard curve was linear over the concentration range of 5–45 µg/mL with R2 close to one (0.9996). The limit of detection (LOD) and limit of Quantitation (LOQ) were determined for Finerenone. The developed method was successfully applied for the quantitative analysis of Finerenone in the pharmaceutical dosage form. The high recovery and low relative standard deviation confirm the suitability of the proposed method for the determination of the Finerenone in the Pharmaceutical dosage form.
The adenosine deaminase family acting on RNA 1 can be a useful diagnostic biomarker in chorioamnionitis
Authors: Nakamura Keiichiro , Shigeyasu Kunitoshi , Maki Juta , Tani Kazumasa , Eto Eriko , Masuyama Hisashi 
Published: June 2023

Abstract

Chorioamnionitis (CAM) is an acute infection leading to preterm birth. However, diagnosis of CAM before delivery is challenging because of its complicated diagnostic criteria. On the other hand, RNA editing is a phenomenon that changes the phenotype by replacing bases at the RNA level and is triggered by inflammation. We investigated the correlation between RNA editing enzyme Adenosine deaminase family acting on RNA 1 (ADAR1) and CAM in clinical specimens derived fromnon-CAM, CAM (pathologically diagnosed), and clinical CAM (clinically diagnosed) patients. ADAR1 was upregulated in the placenta of CAM and clinical CAM patients (p<0.001 and p=0.005). ADAR1 had a significantly higher area under the curve (AUC) (0.735 and 0.828) than other genetic characteristics in diagnosing CAM and clinical CAM patients. ADAR1 also had significantly higher AUC (0.701 and 0.837) than other clinical characteristics for CAM and clinical CAM patients. ADAR1 can be a useful diagnostic biomarker in CAM patients before delivery.
Health care and harm reduction provider perspectives on treating older adults who use non-medical opioids: A Chicago case study
Authors: Mason Maryann , Post Lori Ann , Aggarwal Rahul 
Published: June 2023

Abstract
Background: Opioid overdose death rates are increasing for adults aged 55 and older, with
especially high rates in large urban areas. In parallel, admissions to treatment programs for older adults using illicit substances are increasing as well. Despite these trends, there is a relatively weak understanding of older adults who use non-medical opioids and less knowledge about their health and service encounters. Conducted in Chicago, Illinois, this qualitative study
explores the perspectives of health care and harm reduction service providers who work with
older adults using non-medical opioids.
Methods: The study used snowball sampling to locate participants with expertise in working with older adults who use non-medical opioids. In total, we conducted 24 semi-structured interviews from September 2021-August 2022. We explored questions regarding participants’ perceptions of older adult opioid use patterns, comorbidities, and involvement in harm reduction outreach and opioid use disorder treatment.
Results: Many of the providers we interviewed consider older adults who use non-medical opioids as a distinct population that employ unique use behaviors with the intent to protect them from opioid overdose. However, these same unique behaviors may potentiate their risk for overdose in today’s climate. Providers report initial encounters that are not care seeking for opioid misuse and primarily oriented around health conditions. Older adults who use non-medical opioids are seen as challenging patients due to the need to diagnostically untangle symptoms of substance use from co-morbidities and conditions associated with aging. Treatment for this population is also viewed as complicated due to the interactions between aging, comorbidities, and substance misuse. Providers also noted that older adult non-medical opioid users have use behaviors that make them less visible to outreach and treatment service providers, potentially putting them at increased risk for overdose and health conditions associated with opioid misuse.
Conclusions: Findings from this study are intended to inform future research on care provision for older adults who use non-medical opioids and may be especially applicable in large urban areas with histories of opioid misuse dating back to earlier drug epidemics of the 1970s, 1980s and 1990s.
Regulation of symbiotic interactions and primitive lichen differentiation by UMP1 MAP kinase in Umbilicaria muhlenbergii
Authors: Wang Yanyan , Li Rong , Wang Diwen , Qian Ben , Bian Zhuyun , Wei Jiangchun , Wei Xinli , Xu Jin-Rong 
Published: June 2023

Abstract
Lichens are of great ecological importance but mechanisms regulating lichen symbiosis are not clear. Umbilicaria muhlenbergii is the only lichen-forming fungus amenable to molecular manipulations and dimorphic. Here, we established conditions conducive to symbiotic interactions and lichen differentiation and showed the importance of UMP1 MAP kinase in lichen development. In the initial biofilm-like symbiotic complexes, algal cells were interwoven with pseudohyphae covered with extracellular matrix. After longer incubation, fungal-algal complexes further differentiated into primitive lichen thalli with a melanized epidermis and pseudoparenchyma-like tissues containing photoactive algal cells. Mutants deleted of UMP1 were blocked in pseudohyphal growth and development of biofilm-like complexes and primitive lichens. Invasion of dividing mother cells that contributes to algal layer organization in lichens was not observed in the ump1 mutant. Overall, these results showed regulatory roles of UMP1 in symbiotic interactions and lichen development and suitability of U. muhlenbergii as a model for studying lichen symbiosis.
Drug-resistance genes and antifungal susceptibility of Trichophyton verrucosum variants isolated from bovine skin lesions and farm environments
Authors: Lee Han Gyu , Jung Young-Hun , Cho Ara , Oem Jae Ku , Hur Tai-Young 
Published: June 2023

Abstract

• Background
Trichophyton verrucosum is a zoophilic dermatophyte that causes a highly contagious disease in bovine, and can be occasionally transmitted to humans. Azoles are wildly used as antifungal drugs in bovine; they act by targeting the ergosterol biosynthesis pathway. However, recently, several cases of failure and relapse of dermatophyte infection have been reported due to gene mutations in the drug target site. In addition, subtilisin (SUB) genes play an important role in pathogenesis. However, there is limited information regarding T. verrucosum variants. This study aimed to classify T. verrucosum variants based on their antifungal susceptibility and the presence or absence of ergosterol biosynthesis (ERG) and SUB genes, isolated from animals with clinical symptoms and cattle environments (fence and water bowel) in the Republic of Korea.
• Results
Of 139 clinical samples and 39 environmental samples, 86 and 21 were found to be infected, respectively. The positive ratio of calves aged 1–6 months was 73.1%, which was significantly higher than that of calves aged > 6 months (55.2%). Twenty-seven T. verrucosum strains were identified and classified as T. album (n = 9), T. ochraceum (n = 6), and T. discoides (n = 12). Antifungal susceptibility testing showed that enilconazole had the lowest geometric mean antifungal activity, of 1.08, 1, and 0.94 µg/ml against T. album, T. ochraceum, and T. discoides, respectively. All strains harbored SUB6 and ERG11. The distribution of SUB5, ERG3, and ERG6 among the three variants was significantly different.
• Conclusions
To the best of our knowledge, this is the first report of the antifungal susceptibility and presence/absence of SUB and ERG genes in T. verrucosum variants isolated from bovine and farm environments in the Republic of Korea. This information regarding T. verrucosum variants may help prevent and manage dermatophytosis in cattle.
The relationship between chemical microstructure, crystallinity, mechanical properties, and CO2 / N2 gases permselectivity of thermoplastic polyurethane membranes
Authors: Abedi Reza , MemarMaher Behnaz , Amirkhani Leila , Rezaei Mostafa , Jamshidi Sona 
Published: June 2023

Abstract

In this study, thermoplastic polyurethane (TPU) with 30%wt hard segment content (HSC) was synthesized using isophorone diisocyanate (IPDI), 1, 4-butanediol (BDO) as the chain extender, and polycaprolactone (PCL) with three different molecular weights (2000, 4000, and 10000) as polyols. Fourier-transform infrared spectroscopy (FTIR), hydrogen nuclear magnetic resonance (H-NMR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC) analysis were used to evaluate the chemical microstructure and physical characteristics of polycaprolactones (PCLs) and thermoplastic polyurethanes (TPUs). The results showed that the crystallinity and the glass transition temperature (Tg) of TPUs became different depending on the molecular weight of the PCL soft segments. A tensile strength was used to evaluate the mechanical properties of TPUs. It was observed that increasing the molecular weight of PCL decreased the elongation at break and increased the ultimate tensile strength. The permeability of CO2 and N2 gase over wide ranges of pressure (3 to 9 atm) was examined, and the permselectivity of the membranes was determined. It was concluded that an increase in the feeding gas pressure led to an increase in the gas permeability of all samples. It was observed that in TPU samples, the increase in the molecular weight of PCLs led to a decrement in selectivity and an increase in permeability of CO2 and N2 gas.
Decoding Cortical Activity through Neuronal Tracing Connectome-Harmonics in Marmosets
Authors: Xia Jie , Liu Cirong , Li Jiao , Meng Yao , Yang Siqi , Chen Huafu , Liao Wei 
Published: June 2023

Abstract
Deciphering the complex relationship between neuroanatomical connections and functional activity in primate brains remains a daunting task, especially regarding the influence of monosynaptic connectivity on cortical activity. In this study, we utilized graph signal processing to study the anatomical-functional relationship and decomposed the neuronal-tracing based connectome of marmoset brains into a series of harmonics. These connectomic harmonics effectively decoded cortical activity observed in resting-state functional magnetic resonance imaging, and exposed a patterned cellular-functional dependency. This pattern revealed a spatial gradient from coupled unimodal to decoupled transmodal cortices, and recapitulated the hierarchical organization of cortical structures across both micro-structural and macro-scale spatial properties. Notably, these marmoset-derived harmonics facilitated the inference of human cortical activity and connectivity, underlining the potential of generalizing the connectomic constraints across species. Our findings illuminate how neuronal-tracing connectome harmonics constrain cortical activity and improve our understanding of the brain’s anatomical-functional relationship.
Quantitative Evaluation of China’s Public Health Emergencies Response Policies：A PMC index model approach
Authors: Liu Yongwen , Jiao Min , Wang Yan , Ma Anning 
Published: June 2023

Abstract

Background Public health emergencies response polices (PHERPs) provide a basis and institutional guarantee for the implementation of emergency response work. At present, China has made certain achievements in emergency response for public health emergencies (PHE). In order to further improve the emergency response capability, it is necessary to conduct a systematic analysis of relevant policies, understand their content and role, and clarify directions for policy improvement.Methods Based on 33 comprehensive public health emergencies response policies (PHERPs) released by the central level of China from 2003 to 2019, text mining and content analysis were used to construct a PMC index model with 10 first-lever and 46 second-level variables. The policies were quantitatively evaluated to analyze their strengths and weaknesses.Results In this study, finds that the average PMC index value for the 33 policies was 6.43, with an average rating of acceptable. Among them, 10 policies were rated as excellent, 23 policies were rated as acceptable, and there were no poor policies. For the first-level variables, the mean scores for policy openness, policy structure, policy area, policy focus, and policy nature were relatively high, at 1.00, 0.88, 0.87, 0.85, and 0.86, respectively. However, the scores for policy timeliness, policy issuing agency, incentive measures, policy target, and policy function were relatively low, at 0.25, 0.27, 0.41, 0.54, and 0.50, respectively, which need to be given more attention.Conclusions In this study, we also emphasized that the use of the PMC index model policy evaluation method in researching policies related to emergency response to PHE is relatively rare. These findings contribute to a more comprehensive understanding of the strengths and weaknesses of PHERPs, and provide a reference for further research.
Hybrid Ant Colony and Cuckoo Seach Optimization Protocol for Wsn Assisted Iot Based Agricultural Application
Authors: Sehrawat VATAN , Goyal Sandip Kumar 
Published: June 2023

Abstract
Internet of Things (IoT) has been observed these days in variety of applications where the devices interconnect with each other using Internet and provide much useful information for various purposes. These network are often backed by WSNs where sensors play a significant part in gathering environmental data; this data is processed and used by IoT devices for numerous applications. This paper proposes agricultural application of IoT where the soil moisture content is continuously monitored such that excess watering can be avoided; this leads to water conservation in addition to preventing the crop damage. Furthermore, sensors also monitor the environmental parameters which are responsible for causing fire in the fields. This information is sent to the server where it can be processed and damage to crops can be avoided. The clustering approach has been suggested for underlying sensor system where the main objective function of augmenting the network lifetime and reducing the data delivery delay has been laid out. The cuckoo search optimization (CS) has been used in unison with ant colony algorithm (ACO) to select the optimal cluster heads. The traffic heterogeneity scenario has been considered in the network where the fire sensors has more data to forward to base station as compared to moisture sensors; this traffic heterogeneity has been primarily considered which choosing the optimal CH. Furthermore, the information transmission process from CH to BS is also optimized by forming the paths using ACO and selecting one best out of them for data forwarding. The suggested approach was experiment in MATLAB & contrasted compared with other protocols namely GWO, ESO, GECR and LEACH based on average residual energy of the system, network stability, network lifetime and delivery delay. The suggested approach has managed to achieve good system lifespan & less delivery delays.