bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of consistency between peer‐reviewed publications and clinical trial registrations in nursing journals
Authors: Liu Hui‐Hui , Su Chun‐Xiang , Li Zhang‐Qi , Yue Shu‐Jin , Cheng Shu‐Han , Peng Di 
Published: April 2023

AbstractBackgroundThe inconsistencies between randomized clinical trials (RCTs) registrations and peer‐reviewed publications may distort trial results and threaten the validity of evidence‐based medicine. Previous studies have found many inconsistencies between RCTs registrations and peer‐reviewed publications, and outcome reporting bias is prevalent.AimsThe aims of this review were to assess whether the primary outcomes and other data reported in publications and registered records in RCTs of nursing journals were consistent and whether discrepancies in the reporting of primary outcomes favored statistically significant results. Moreover, we reviewed the proportion of RCTs for prospective registration.MethodsWe systematically searched PubMed for RCTs published in the top 10 nursing journals between March 5, 2020, and March 5, 2022. Registration numbers were extracted from the publications, and registered records were identified from the registration platforms. The publications and registered records were compared to identify consistency. Inconsistencies were subdivided into discrepancies and omissions.ResultsA total of 70 RCTs published in seven journals were included. The inconsistencies involved sample size estimation (71.4%), random sequence generation (75.7%), allocation concealment (97.1%), blinding (82.9%), primary outcomes (60.0%) and secondary outcomes (84.3%). Among the inconsistencies in the primary outcomes, 21.4% were due to discrepancies and 38.6% resulted from omissions. Fifty‐three percent (8/15) presented discrepancies in the primary outcomes that favored statistically significant results. Additionally, although only 40.0% of the studies were prospective registrations, the number of prospectively registered trials has trended upward over time.Linking Evidence to ActionWhile not including all RCTs in the nursing field, our sample reflected a general trend: inconsistencies between publications and trial registrations were prevalent in the included nursing journals. Our research helps to provide a way to improve the transparency of research reports. Ensuring that clinical practice has access to transparent and reliable research results are essential to achieve the best possible evidence‐based medicine.
A CO‐LIBERATORY FRAMEWORK FOR BIG DATA
Authors: Johnson Matthew Kuan , Robertson Rachel Siow 
Published: April 2023

AbstractThis article provides an account of the ethical issues that arise when digital technologies and online spaces are structured by Big Data algorithms. We show that although the uses of Big Data may be new, traditional theological and ethical categories are still applicable, including “the sins of the fathers” from hamartiology and the scholastic concept of haecceity. Using these resources, we map the overall ecosystem in which digital technologies are developed and used, identifying the relationships between the individuals and organizations involved. We show how these relationships are often characterized by various kinds of harm. We then argue for a reorientation of the tech ecosystem toward co‐liberation—and ultimately, joy.
A Faber–Krahn inequality for Wavelet transforms
Authors: Ramos João P. G. , Tilli Paolo 
Published: April 2023

AbstractFor some special window functions , we prove that, over all sets of fixed hyperbolic measure , those for which the Wavelet transform with window concentrates optimally are exactly the discs with respect to the pseudo‐hyperbolic metric of the upper half space. This answers a question raised by Abreu and Dörfler in Abreu and Dörfler (Inverse Problems 28 (2012) 16). Our techniques make use of a framework recently developed by Nicola and Tilli in Nicola and Tilli (Invent. Math. 230 (2022) 1–30), but in the hyperbolic context induced by the dilation symmetry of the Wavelet transform. This leads us naturally to use a hyperbolic rearrangement function, as well as the hyperbolic isoperimetric inequality, in our analysis.
Natural processes leading to large, pre-historic hydrothermal eruptions in geothermal areas: Rotokawa geothermal field, New Zealand
Authors: Montanaro Cristian , Cronin Shane J. , Lerner Geoffrey A. , Simpson Mark P. , Brooks-Clarke Isabelle , Swanney Gina , Milicich Sarah D. , Calibugan Aimee , Bardsley Candice , Scheu Bettina 
Published: April 2023

Hydrothermal eruptions are the most violent and hazardous phenomena within geothermal fields. The largest of these may produce kilometer-sized craters and breccia deposits that are tens of meters thick. The geological and hydrothermal priming that leads to these types of eruptions is poorly understood. To understand large hydrothermal eruptions, we investigated a series of prehistoric events at the Rotokawa geothermal field in New Zealand. By revising the stratigraphy and distribution of hydrothermal breccia deposits and correlating these with componentry, crater morphology, and subsurface geological structure, we estimated the frequency, priming processes, triggers, and dynamics of multiple eruptions.
Seventeen large hydrothermal eruptions occurred centuries to millennia apart in the period from ca. 22 cal ka B.P. to ca. 3.4 cal ka B.P. Of six hydrothermal eruptions since ca. 7 ka, four produced oval-shaped craters up to 2 km in diameter, creating a broad, shallow depression within the geothermal field. The two youngest eruptions occurred northeast of earlier eruption centers and have narrower and elongated vents. We infer that in the central depression, newly formed craters rimmed by breccia deposits and high-relief country rock hosted temporary lakes tens of meters deep. Crater-lake breakout(s) and/or seismic events caused sudden pressure reduction above the hydrothermal aquifer, triggering hydrothermal eruptions. Northeast of the basin, hydrothermal alteration produced caprocks above intensively fractured areas. In this case, earthquakes are the most likely trigger for cap-rupture and eruption. All eruptions excavated shallow and large craters mostly within partially altered Oruanui Formation and pre-fragmented breccias. The size and localization of the eruptions was likely due to a combination of (1) availability of undisturbed porous ignimbrite hosting large thermal aquifers, (2) efficient crater excavation within or alongside pre-fragmented breccia, and (3) the location of fracture and fault zones that channeled deep fluid upflow, favoring priming processes.
This study highlights how an interplay of tectonic, magmatic, and hydrologic processes is responsible for the timing, dynamics, and ultimate size of hydrothermal eruptions in geothermal fields. Some events may be very large and destructive depending on the right priming and geological conditions.
The impact of COVID-19 on global health journals: an analysis of impact factor and publication trends
Authors: He Jiaxin , Liu Xinliang , Lu Xinyang , Zhong Meiling , Jia Changli , Lucero-Prisno Don Eliseo , Ma Zheng Feei , Li Hao 
Published: April 2023

BackgroundCOVID-19 has affected research productivity across all areas of knowledge. Current evidence suggests that COVID-19 has had a blockbuster effect on journal impact factors (JIFs) and publication trends, while little is known on global health journals.MethodsTwenty global health journals were included to analyse the impact of COVID-19 on their JIFs and publication trends. Indicator data, including numbers of publications, citations, articles with different types, etc, were extracted from journal websites and Web of Science Core Collection database. The JIFs from 2019 to 2021 were simulated for longitudinal and cross-sectional analyses. Interrupted time-series analysis and non-parametric tests were applied to assess whether COVID-19 had decreased non-COVID-19 publications from January 2018 to June 2022.ResultsIn 2020, 615 out of 3223 publications were COVID-19 related, accounting for 19.08%. The simulated JIFs of 17 out of 20 journals in 2021 were higher than those in 2019 and 2020. Notably, 18 out of 20 journals had a decrease in their simulated JIFs after excluding COVID-19-related publications. Moreover, 10 out of 20 journals decreased their monthly numbers of non-COVID-19 publications after the COVID-19 outbreak. For all the 20 journals as a whole, after the COVID-19 outbreak in February 2020, the total number of non-COVID-19 publications significantly decreased by 14.2 compared with the previous month (p=0.013), and since then, on average, the publications had decreased by 0.6 per month until June 2022 (p<0.001).ConclusionsCOVID-19 has impacted the structure of COVID-19-related publications, the JIFs of global health journals and their numbers of non-COVID-19 publications. Although journals may benefit from increased JIFs, global health journals should avoid relying on a single metric. More follow-up studies including more years of data with a combination of metrics should be conducted to generate more robust evidence.
Exploring the use of a gamified intervention for encouraging physical activity in adolescents: a qualitative longitudinal study in Northern Ireland
Authors: Corepal Rekesh , Best Paul , O’Neill Roisin , Tully Mark A , Edwards Mark , Jago Russell , Miller Sarah J , Kee Frank , Hunter Ruth F 
Published: April 2023

ObjectiveTo explore the temporal changes of adolescents’ views and experiences of participating in a gamified intervention to encourage physical activity behaviour and associated processes of behaviour change.DesignA qualitative longitudinal design was adopted whereby focus groups were conducted with the same participants in each intervention school (n=3) at four time-points (baseline, end of each of two intervention phases and 1-year follow-up). The framework method was used to thematically analyse the data.SettingSecondary schools (n=3), Belfast (Northern Ireland).ParticipantsA subsample (n=19 at four time-points) of individuals aged 12–14 years who participated in the StepSmart Challenge, a gamified intervention involving a pedometer competition and material rewards to encourage physical activity behaviour change.ResultsThree core themes were identified: (1) competition; (2) incentives and (3) influence of friends. Participants indicated that a pedometer competition may help initiate physical activity but suggested that there were a number of barriers such as participants finding it ‘boring’, and feeling as though they had a remote chance of ‘winning’. ‘Incentives’ were viewed favourably, although there were participants who found not winning a prize ‘annoying’. Friends were a motivator to be more physically active, particularly for girls who felt encouraged to walk more when with a friend.ConclusionsThe intervention in general and specific gamified elements were generally viewed positively and deemed acceptable. Results suggest that gamification may have an important role to play in encouraging adolescents to engage in physical activity and in creating interventions that are fun and enjoyable. The longitudinal approach added additional depth to the analysis as themes were refined and tested with participants over time. The findings also suggest that gamified Behaviour Change Techniques align well with core concepts of Self-determination Theory and that various game elements may require tailoring for specific populations, for example, different genders.Trial registration numberNCT02455986; Pre-results.
Randomised controlled trial of a Calcium Channel or Angiotensin Converting Enzyme Inhibitor/Angiotensin Receptor Blocker Regime to Reduce Blood Pressure Variability following Ischaemic Stroke (CAARBS): a protocol for a feasibility study
Authors: Robinson Thompson G , Davison William J , Rothwell Peter M , Potter John F 
Published: April 2023

IntroductionRaised blood pressure (BP) is common after stroke and is associated with a poor prognosis, yet trials of BP lowering in the immediate poststroke period have not demonstrated a benefit. One possible explanation for this may be that BP variability (BPV) rather than absolute levels predicts outcome, as BPV is increased after stroke and is associated with poor outcomes. Furthermore, there is evidence of distinct antihypertensive class effects on BPV despite similar BP-lowering effects. However, whether BPV in the immediate poststroke period is a therapeutic target has not been prospectively investigated.The objectives of this trial are to assess the feasibility and safety of recruiting patients following an acute ischaemic stroke or transient ischaemic attack (TIA) to an interventional randomised controlled trial comparing the effects of two different antihypertensive drug classes on BPV. Secondary exploratory objectives are to assess if different therapeutic strategies have diverse effects on levels of BPV and if this has an impact on outcomes.Methods150 adult patients with first-ever ischaemic stroke or TIA who require antihypertensive therapy for secondary prevention will be recruited within 7 days of the event from stroke services across three sites. After baseline assessments they will be randomly assigned to treatment with a calcium channel blocker or ACE inhibitor/angiotensin receptor blocker-based regimen and followed up for a period of three months.Ethics and disseminationEthical and regulatory approvals have been granted. Dissemination is planned via publication in peer-reviewed medical journals and presentation at relevant conferences.Trial registration numberISRCTN10853487.
International prospective observational study investigating the disease course and heterogeneity of paediatric-onset inflammatory bowel disease: the protocol of the PIBD-SETQuality inception cohort study
Authors: Aardoom Martine A , Kemos Polychronis , Tindemans Irma , Aloi Marina , Koletzko Sibylle , Levine Arie , Turner Dan , Veereman Gigi , Neyt Mattias , Russell Richard K , Walters Thomas D , Ruemmele Frank M , Samsom Janneke N , Croft Nicholas M , de Ridder Lissy 
Published: April 2023

IntroductionPatients with paediatric-onset inflammatory bowel disease (PIBD) may develop a complicated disease course, including growth failure, bowel resection at young age and treatment-related adverse events, all of which can have significant and lasting effects on the patient’s development and quality of life. Unfortunately, we are still not able to fully explain the heterogeneity between patients and their disease course and predict which patients will respond to certain therapies or are most at risk of developing a more complicated disease course. To investigate this, large prospective studies with long-term follow-up are needed. Currently, no such European or Asian international cohorts exist. In this international cohort, we aim to evaluate disease course and which patients are most at risk of therapy non-response or development of complicated disease based on patient and disease characteristics, immune pathology and environmental and socioeconomic factors.Methods and analysisIn this international prospective observational study, which is part of the PIBD Network for Safety, Efficacy, Treatment and Quality improvement of care (PIBD-SETQuality), children diagnosed with inflammatory bowel disease <18 years are included at diagnosis. The follow-up schedule is in line with standard PIBD care and is intended to continue up to 20 years. Patient and disease characteristics, as well as results of investigations, are collected at baseline and during follow-up. In addition, environmental factors are being assessed (eg, parent’s smoking behaviour, dietary factors and antibiotic use). In specific centres with the ability to perform extensive immunological analyses, blood samples and intestinal biopsies are being collected and analysed (flow cytometry, plasma proteomics, mRNA expression and immunohistochemistry) in therapy-naïve patients and during follow-up.Ethics and disseminationMedical ethical approval has been obtained prior to patient recruitment for all sites. The results will be disseminated through peer-reviewed scientific publications.Trial registration numberNCT03571373.
sPinal coRd stimulatiOn coMpared with lumbar InStrumEntation for low back pain after previous lumbar decompression (PROMISE): a prospective multicentre RCT
Authors: Krauss Philipp , Motov Stefan , Bonk Maximilian Niklas , Prescher Andrea , Scorzin Jasmin , Hajiabadi Mohammad Mehdi , Schulte Dirk Michael , Sommer Bjoern , Seiz-Rosenhagen Marcel , Ahmadi Rezvan , Maciaczyk Jaroslaw , Lehmberg Jens , Shiban Ehab 
Published: April 2023

IntroductionPersistent spine pain syndrome type 2 (PSPS2) represents a significant burden to the individual and society. Treatment options include revision surgery, stabilisation surgery of the spine, neuromodulation, analgesics and cognitive behavioural therapy. Nevertheless, structured treatment algorithms are missing as high-level evidence on the various treatments is sparse. The aim of this study is to compare higher frequency neuromodulation with instrumentation surgery in patients suffering from PSPS2.Methods and analysisThe sPinal coRd stimulatiOn coMpared with lumbar InStrumEntation for low back pain after previous lumbar decompression (PROMISE) trial is a prospective randomised rater blinded multicentre study. Patients suffering from PSPS2 with a functional burden of Oswestry Disability Index (ODI) >20 points are randomised to treatment via spinal cord stimulation or spinal instrumentation. Primary outcome is back-related functional outcome according to the ODI 12 months after treatment. Secondary outcomes include pain perception (visual analogue scale), Short Form-36, EuroQOL5D, the amount of analgesics, the length of periprocedural hospitalisation and adverse events. Follow-up visits are planned at 3 and 12 months after treatment. Patients with previous lumbar instrumentation, symptomatic spinal stenosis, radiographical apparent spinal instability or severe psychiatric or systemic comorbidities are excluded from the study. In order to detect a significant difference of ≥10 points (ODI) with a power of 80%, n=72 patients need to be included. The recruitment period will be 24 months with a subsequent 12 months follow-up. The beginning of enrolment is planned for October 2022.Ethics and disseminationThe PROMISE trial is the first randomised rater blinded multicentre study comparing the functional effectiveness of spinal instrumentation versus neuromodulation in patients with PSPS2 in order to achieve high-level evidence for these commonly used treatment options in this severely disabling condition. Patient recruitment will be performed at regular outpatient clinic visits. No further (print, social media) publicity is planned. The study is approved by the local ethics committee (LMU Munich, Germany) and will be conducted according to the Declaration of Helsinki.Trial registration numberNCT05466110.
Epidemiology and Management of invasive infections among people who Use drugs (EMU): protocol for a prospective, multicentre cohort study
Authors: Attwood Lucy O , Bryant Mellissa , Lee Sue J , Vujovic Olga , Higgs Peter , Doyle Joseph S , Stewardson Andrew J 
Published: April 2023

IntroductionPeople who inject drugs (PWID) are at risk of invasive infections such as bloodstream infections, endocarditis, osteomyelitis and septic arthritis. Such infections require prolonged antibiotic therapy, but there is limited evidence about the optimal care model to deliver to this population. The Epidemiology and Management of invasive infections among people who Use drugs (EMU) study aims to (1) describe the current burden, clinical spectrum, management and outcomes of invasive infections in PWID; (2) determine the impact of currently available models of care on completion of planned antimicrobials for PWID admitted to hospital with invasive infections and (3) determine postdischarge outcomes of PWID admitted with invasive infections at 30 and 90 days.Methods and analysisEMU is a prospective multicentre cohort study of Australian public hospitals who provide care to PWIDs with invasive infections. All patients who have injected drugs in the previous six months and are admitted to a participating site for management of an invasive infection are eligible. EMU has two components: (1) EMU-Audit will collect information from medical records, including demographics, clinical presentation, management and outcomes; (2) EMU-Cohort will augment this with interviews at baseline, 30 and 90 days post-discharge, and data linkage examining readmission rates and mortality. The primary exposure is antimicrobial treatment modality, categorised as inpatient intravenous antimicrobials, outpatient antimicrobial therapy, early oral antibiotics or lipoglycopeptide. The primary outcome is confirmed completion of planned antimicrobials. We aim to recruit 146 participants over a 2-year period.Ethics and disseminationEMU has been approved by the Alfred Hospital Human Research Ethics Committee (Project number 78815.) EMU-Audit will collect non-identifiable data with a waiver of consent. EMU-Cohort will collect identifiable data with informed consent. Findings will be presented at scientific conferences and disseminated by peer-review publications.Trial registration numberACTRN12622001173785; Pre-results.
Diabetic retinopathy progression in patients under monitoring for treatment or vision loss: external validation and update of a multivariable prediction model
Authors: Haider Sajjad , Adderley Nicola , Tallouzi Mohammad O , Sadiq Salman Naveed , Steel David H , Chavan Randhir , Sheikh Ijaz , Nirantharakumar Krishnarajah , Snell Kym I E 
Published: April 2023

IntroductionThe number of people with diabetes mellitus is increasing globally and consequently so too is diabetic retinopathy (DR). Most patients with diabetes are monitored through the diabetic eye screening programme (DESP) until they have signs of retinopathy and these changes progress, requiring referral into hospital eye services (HES). Here, they continue to be monitored until they require treatment. Due to current pressures on HES, delays can occur, leading to harm. There is a need to triage patients based on their individual risk. At present, patients are stratified according to retinopathy stage alone, yet other risk factors like glycated haemoglobin (HbA1c) may be useful. Therefore, a prediction model that combines multiple prognostic factors to predict progression will be useful for triage in this setting to improve care.We previously developed a Diabetic Retinopathy Progression model to Treatment or Vision Loss (DRPTVL-UK) using a large primary care database. The aim of the present study is to externally validate the DRPTVL-UK model in a secondary care setting, specifically in a population under care by HES. This study will also provide an opportunity to update the model by considering additional predictors not previously available.Methods and analysisWe will use a retrospective cohort of 2400 patients with diabetes aged 12 years and over, referred from DESP to the NHS hospital trusts with referable DR between 2013 and 2016, with follow-up information recorded until December 2021.We will evaluate the external validity of the DRPTVL-UK model using measures of discrimination, calibration and net benefit. In addition, consensus meetings will be held to agree on acceptable risk thresholds for triage within the HES system.Ethics and disseminationThis study was approved by REC (ref 22/SC/0425, 05/12/2022, Hampshire A Research Ethics Committee). The results of the study will be published in a peer-reviewed journal, presented at clinical conferences.Trial Registration numberISRCTN 10956293.