bluuebunny/crossref_metadata_2025_split huggingface dataset:
ThyNod Panel efficiently identifies genetic characteristics of thyroid nodules
Authors: Li Haorong , Han Rulai , Zhou Wei , Zhao Ming , Wan Zhihan , Meng Lingyang , Xie Jing , Yu Danyan , Xie Xiaoyan , Shen Liyun , Zhou Yulin , Wang Shu , Yan Jiqi , Ye Lei , Wang Weiqing 
Published: July 2023

Abstract
Purpose
We aimed to establish a next-generation sequencing panel for the molecular diagnosis of thyroid nodules.
Methods
The panel, named ThyNod Panel, was designed to detect SNV, indel, fusion, CNV in 48 thyroid malignancy associated genes as rule in markers, 3 benign associated genes as rule out markers, RNA expression levels in 16 thyroid differentiation/function genes and 23 cell identity marker genes. We retrospectively tested 68 frozen/4 FFPE tissues and prospectively tested 107 thyroid FNA samples.
Results
Seventeen nodules were C cell origin, one was parathyroid and the others were follicular cell. For follicular cell derived thyroid nodules, 123/161 (76%) were found mutations: malignancy associated mutations were BRAF V600E (n = 80), RAS mutations (n = 12), RET/PTC fusions (n = 7), NTRK3 fusions (n = 6) and, BRAF fusions (n = 4), PIK3CA mutations (n = 3); benign associated mutations were identified in 3 nodules, all with SPOP mutations. The accuracy of the ThyNod Panel in diagnosing malignant and benign follicular cell derived thyroid nodules was 91.30% (95% CI, 85.58–96.17), with sensitivity and specificity as 98.68% and 56.25%; for Bethesda category III/IV nodules, nine (64%, 9/14) were positive with malignancy associated mutations and molecular findings in 67% (4/6) nodules were consistent with histopathologic diagnosis. Eight nodules carried two or more driver alterations, two with ATA high-risk thyroid cancers.
Conclusion
ThyNod Panel can efficiently identify genetic characteristics in thyroid nodules and be applied in the molecular diagnosis of thyroid nodules.
Evaluation of a novel CBCT conversion method implemented in a treatment planning system
Authors: Lechner Wolfgang , Kanalas Dávid , Haupt Sarah , Lukas Zimmermann , Georg Dietmar 
Published: July 2023

Abstract
Background:
To evaluate a novel CBCT conversion algorithm for dose calculation implemented in a research version of a treatment planning system (TPS).
Methods:
The algorithm was implemented in a research version of RayStation (v. 11B-DTK, RaySearch, Stockholm, Sweden). CBCTs acquired for each ten head and neck (HN), gynecology (GYN) and lung cancer (LNG) patients were collected and converted using the new algorithm (CBCTc). A bulk density overriding technique implemented in the same version of the TPS was used for comparison (CBCTb). A deformed CT (dCT) was created by using deformable image registration of the planning CT (pCT) to the CBCT to reduce anatomical changes. All treatment plans were recalculated on the pCT, dCT, CBCTc and the CBCTb. The resulting dose distributions were analyzed using the MICE toolkit (NONPIMedical AB Sweden, Umeå) with local gamma analysis, with 1% dose difference and 1 mm distance to agreement criteria. A Wilcoxon paired rank sum test was applied to test the differences in gamma pass rates (GPRs). A p-value smaller than 0.05 considered statistically significant.
Results:
The GPRs for the CBCTb method were systematically lower compared to the CBCTc method. Using the 10% dose threshold and the dCT as reference the median GPRs were for the CBCTc method were 100% and 99.8% for the HN and GYN cases, respectively. Compared to that the GPRs of the CBCTb method were lower with values of 99.8% and 98.0%, for the HN and GYN cases, respectively. The GPRs of the LNG cases were 99.9% and 97.5% for the CBCTc and CBCTb method, respectively. These differences were statistically significant. The main differences between the dose calculated on the CBCTs and the pCTs were found in regions near air/tissue interfaces, which are also subject to anatomical variations.
Conclusion:
The dose distribution calculated using the new CBCTc method showed excellent agreement with the dose calculated using dCT and pCT and was superior to the CBCTb method. The main reasons for deviations of the calculated dose distribution were caused by anatomical variations between the pCT and the corrected CBCT.
Study of Removal conditions optimization for heavy metal from recycled formation water of oil field based on chitosan polymer and its quantum calculation
Authors: Khowdiary Manal M. , Sheta Mai , Taha Nahla Ahmed , Elhenawy Ahmed A. , Eweida Basant yousri 
Published: July 2023

Abstract
Specific objective for this study was to stabilize a valid method to remove copper from recycled formation water from oil field. Chitosan used for Cu+ 2adsorption from simulated wastewater. Comparison between commercial (CC) and natural prepared chitosan (NC) from shrimps shell, also CC and NC was grafted for enhancing the efficiency of remove tested metal ions. By studying removal of Cu+ 2 across certain parameters as concentration, adsorbent dose, contact time and pH. The results summarized that maximum % removal for all types used was at 20 ppm with value of 94% for CC and NC ,96% for CGC and 98% for NGC after 3hr, 1g and pH = 7. While reaches about 99% removals by increasing adsorbent dose to 4 g for NGC and CGC. Different adsorption isotherms were studied for the remove of Cu+ 2 ions. Also the rate of Adsorption for different types of chitosan used was pseudo 1st order, pseudo 2nd order and Elvoich equation. The kinetic data were analyzed by the intra-particle diffusion model and liquid film diffusion model for Cu+ 2 adsorption using different types of chitosan to study the mechanism of reaction for each type. Significantly, in order to scale up this effective technique on an industrial scale, response surface methodology (RSM) as a modelling tool Statistical Software for further copper ion removal used. The DFT using B3LYP and utilized with 6- 311G* correlation function applied for investigated probs. DFT, and MEPs, also, used to identify the interaction compounds behavior over heavy metal for formation water.
Prevalence of opioid-induced adverse events across opioids commonly used for analgesic treatment in Japan: a multicenter prospective longitudinal study
Authors: Hiratsuka Yusuke , Tagami Keita , Inoue Akira , Sato Mamiko , Matsuda Yasufumi , Kosugi Kazuhiro , Kubo Emi , Natsume Maika , Ishiki Hiroto , Arakawa Sayaka , Shimizu Masaki , Yokomichi Naosuke , Chiu Shih-Wei , Shimoda Mayu , Hirayama Hideyuki , Nishijima Kaoru , Ouchi Kota , Shimoi Tatsunori , Shigeno Tomoko , Yamaguchi Takuhiro , Miyashita Mitsunori , Morita Tatsuya , Satomi Eriko 
Published: July 2023

Abstract
Purpose:
Although opioids have been shown to be effective for cancer pain, opioid-induced adverse events (AEs) are common. To date, there is very little evidence suggesting that any one opioid agonist has a substantially better AE profile than any other. This study was performed to compare the prevalence of AEs across opioids commonly used for analgesic treatment in Japan.
Methods:
This study was conducted as a preplanned secondary analysis of a multicenter prospective longitudinal study of inpatients with cancer pain who received specialized palliative care for cancer pain relief. We assessed daily AEs until termination of follow-up. We rated the severity of AEs based on the Common Terminology Criteria for Adverse Events version 5.0. We computed adjusted odds ratios for each AE (constipation, nausea and vomiting, delirium, and drowsiness) with the following variables: opioid, age, sex, renal dysfunction, and primary cancer site.
Results:
In total, 465 patients were analyzed. Based on the descriptive analysis, the top four most commonly used opioids were included in the analysis: oxycodone, hydromorphone, fentanyl, and tramadol. With respect to the prevalence of AEs among all analyzed patients, delirium (n=25, 6.3%) was the most frequent, followed by drowsiness (n=21, 5.3%), nausea and vomiting (n=19, 4.8%), and constipation (n=28, 4.6%). The multivariate logistic analysis showed that no single opioid was identified as a statistically significant independent predictor of any AE.
Conclusion:
There was no significant difference in the prevalence of AEs among oxycodone, fentanyl, hydromorphone, and tramadol, which are commonly used for analgesic treatment in Japan.
Improved Trapdoors and Public Key Search Encryption Based on Middle-Product LWE
Authors: Yao Yun-Fei , Wang Jian-Hua , Wang Ke , Shen Lin-Zhi , Yu Hao-Yang , Chen Hui-Yan 
Published: July 2023

Abstract
Middle-product learning with errors (MP-LWE) was proposed in 2017 by Rosa et al., it is considered to be a method that combines the high efficiency of the R-LWE with the security guarantee of the ordinary LWE. Following the idea of this problem, in the TCC 2019, Alex Lombardi et al. further studied the method of constructing identity-based encryption (IBE) scheme on the premise of the MP-LWE. They introduced several major technologies, these include the introduction of a new leftover hash lemma and the instan-tiation of a brand-new variant of lattice trapdoor corresponding to MP-LWE.
The idea of instantiation of trapdoor is very novel, but the equation can not be solved correctly by using the trapdoor. In the current work, we have improved the research results of the Lombardi et al., that is, we re-instantiate the trapdoor matching MP-LWE and use it to construct a new IBE scheme. Further, we also use the classical transformation of Abdalla et al. to transform the constructed IBE scheme into a MP-LWE-based public key search encryption scheme (PEKS). Compared to IBE and PEKS schemes from LWE, our scheme is more effective, and their ciphertexts and keys size are only O˜(n) in size (for identities of size n bits). Compared to IBE and PEKS schemes from ring-LWE, our schemes have similar efficiency
Lira: Rotational Invariant Shape and Electrostatic Descriptors for Small Molecules based on Real Spherical Harmonics
Authors: Montalvão Rinaldo , Caires Fernando , Silva Samuel , Veríssimo-Alves Marcos , Pinheiro Vitor 
Published: July 2023

Abstract
Background: Modern AI-based tools are increasing the number of protein structures available, creating an opportunity and a challenge for automated high-throughput drug discovery pipelines. The amount of data is overwhelming for current methods, thus demanding new high-performance approaches for Machine Learning-based rational drug design.
Results: As shape and electrostatics are the main elements for understanding protein-ligand interaction, we used them to create a system of efficient and AI-compatible descriptors. This method, called LIRA, describes, compares and analyses shape and electrostatics for small ligands. It can generate databases with descriptors for tens of millions of shapes in a few hours, which can then be queried in seconds. The Lira design, focused on performance and reliability, makes its integration into AI-driven rational drug design pipelines simple.
Conclusions: Given an input query, we demonstrate that spherical harmonics can be used as the basis of an accurate and efficient platform for searching, selecting and comparing molecules for shape and electrostatics. It can be employed to efficiently compare large numbers of molecules, establishing a robust and compact method for describing and comparing the molecular shape and electrostatic potential suitable for Machine and Deep Learning applications. It also can be integrated with other structural software to create signatures directly based on the pocket characteristics of protein targets, thus accelerating novel lead identification. In addition, ongoing medicinal chemistry campaigns can benefit from applying Lira as the starting point for AI-guided drug development and lead maturation.
Modeling and experimental analysis of ultrasonic vibration drilling force prediction model for tiny small holes in high body fraction aluminum-based silicon carbide composites
Authors: Yang Shuaikun , Tong Jinglin , Zhang Zhipeng , Ye Yanqiu , Zhai Haojie , Tao Hongqing 
Published: July 2023

Abstract
A new theoretical mechanical model was proposed by the study, which takes into account ultrasonic vibrations and undeformed cutting thickness. By analyzing the kinematic characteristics of ultrasonic vibration, the undeformed cutting thickness under ultrasonic vibration drilling is calculated, and the theoretical analysis of axial forces and torques is carried out by using the model with simulation software. The results show that both the theoretical drilling force model and the 3D drilling simulation can predict the average axial force and average torque of SiCp/Al composite drilling process more accurately, and the simulation prediction results are better than the prediction results of the theoretical model. The average error of the simulated axial force is 7.11% and the average error of the torque is 7.19%, and the average error of the theoretical axial force is 10.49% and the average error of the torque is 13.05%.
Comparison of the effects of chewing versus smoking tobacco on corneal endothelial health
Authors: Jha Ashok , Gnanaraj Ramya , Gogia Atul , Priya Charima , Verma Aditya 
Published: July 2023

Abstract
Purpose: To evaluate the effect of chewing versus smoking tobacco on corneal endothelial health.
Methods: This was a cross-sectional, observational study analyzing 1797 eyes of 1797 patients. The study cohorts comprised tobacco smokers (N=605); tobacco chewers (N=595), and non-tobacco users (N=597). All the subjects underwent corneal endothelial evaluation by non-contact specular microscopy (EM 4000 Tomey Nishi-Ku, Nagoya, Aichi, Japan). Endothelial cell density (ECD; cells/mm2), coefficient of variation in cell size (CV; %), hexagonality (Hex; %), and central corneal thickness (CCT; µm) were recorded and compared among the 3 groups.
Results: ECD (p<0.001) was significantly lower in chewers when compared to smokers, and was significantly highest in non-tobacco users, whereas CV (p<0.001) and CCT (p=0.009) were found to be significantly higher in chewers when compared to smokers and non-tobacco users. Hex (p<0.001) was significantly lower in chewers when compared with non-tobacco users and smokers. Multivariate linear regression analysis showed that increasing age was a significantly important factor in both the smokers and chewers in all the study parameters (negatively for ECD, Hex, and CCT; and positively for CV), except for CCT in chewers. Frequency and duration of smoking were significantly associated with higher CCT in smokers as well as chewers, whereas the duration of tobacco chewing negatively impacted ECD and Hex in chewers additionally.
Conclusions: Chewing tobacco, especially long-term, appears to be detrimental to the corneal endothelial structure when compared to smoking.
A Simple Assay for Identifying Innate Immune Defects Upstream of Nf-Kb – A Case Report
Authors: Englmeier Ludwig , Sieweke Michael , Nitsche Jessica , Subburayalu Julien 
Published: July 2023

Abstract
We suggest a simple non-invasive point-of-care (POC) diagnostic assay which should allow the identification of individuals who have a defect in a signaling pathway upstream of NF-kB. In this case report we show that activators of toll-like-receptors (TLRs) produce an observable inflammatory response (red spot, “erythema”) when administered onto the skin of an immunocompetent individual in the context of a skin prick test. We suggest that this readout will allow for a simple diagnostic assay, as it will be missing in patients with corresponding inborn errors of signaling pathways upstream of NF-kB. We suggest that this simple assay will allow population-wide screens for individuals with a TLR loss-of-function, as well as for individuals with defects further downstream, such as interleukin-1 receptor-associated kinase 4 (IRAK4)- or MYD88-deficiency. Thus, we expect that activators of signaling pathways upstream of NF-kB will become useful tools for future diagnostic routine testing in a point-of-care (POC) setting.
Establishing the instances of empathy and friendship among youth peer groups involved in the four juvenile sports clubs
Authors: Hogan Conor 
Published: July 2023

Abstract
Sports participation can develop the minds and bodies of young people. It can also facilitate positive social interaction. In this world of growing online interaction, young people can benefit from what sport gives to them and develop them into good citizens. Within this paper, the instances of empathy and friendship among youth peer groups from 11 to 18 years old involved in the four juvenile sports clubs on the east side of Galway city, Ireland are identified. These clubs include the participation of males and females in amateur sports. As a result of this paper, the young sporting participants demonstrated consistent empathy, are affected by others’ emotions, and are aware of their feelings. Within this article, a discussion of the results occurs to emphasise how these sporting clubs are a place for developing good human skills as well as providing the more obvious physical benefits of sports participation and positive real life social interaction.
A mixed method study on the impact of COVID-19 on mental healthcare in Ghana: rethinking Mental Health service delivery
Authors: Zobi Michael , Abrokwa Seth Kofi , Dordoye Eugene , Phuti Angel 
Published: July 2023

Abstract
Background Since its emergence, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused severe health, social and economic challenges. Mental healthcare has been significantly affected globally, and even worse in developing countries. An emerging economy like Ghana in West Africa was not spared its disruptive effects. This study aimed to elucidate the impact of the coronavirus disease 2019, the COVID-19 pandemic (caused by SARS-CoV-2), on Ghana's mental healthcare system.Methods A cross-sectional study using a mixed-method design was conducted in all three psychiatric hospitals in Ghana and the mental health department of a new teaching hospital. Data from the hospital registry and semi-structured interviews were collected and analy’sed.Results In 2020, hospital attendance and admissions declined substantially in all four facilities when compared to the previous year, 2019. The main facility-specific protocol amendments to contain and curb the spread of COVID-19 included changes in patients’ admissions, adherence counselling, dispensing of medications, and treatment modes. These amendments, along with other factors such as stigma, the fear of contracting SARS-CoV-2 among healthcare workers, medication shortages, and logistical challenges, were reported to significantly affect mental health services during the pandemic. Anxiety, increased workload, and stress among healthcare workers were notable effects of challenges due to the pandemic.Conclusion This study highlights the challenges in mental healthcare during the COVID-19 pandemic in Ghana. The experiences encountered present an opportunity to gain insights into future pandemic preparedness and establish a framework for optimal mental healthcare delivery in Ghana.
Oxidative stress and inflammatory markers in ovarian follicular fluid of women with diminished ovarian reserve during in vitro fertilization
Authors: Huang Yan , Cheng Yi , Zhang Min , Xia Yan , Chen Xiaoyan , Xian Yexing , Lin Dewei , Xie Suyan , Guo Xinyu 
Published: July 2023

Abstract
Background
Follicular microenvironment has been proposed as an important factor for oocyte grown and maturation. We sought to evaluate the oxidative stress and inflammatory levels in follicular fluid and association with embryo quality in patients with diminished ovarian reserve (DOR).
Methods
The current research included 46 DOR cases and 56 NOR cases.Twelve representative oxidative stress markers and eight representative inflammatory factors were measured in thefollicular fluid (FF).
Results
Oxidative stress markers T-GSH was decreased in the FF from women with DOR compared with that in NOR group (P = 0.041). More modest differences were observed for reduced GSH and reduced GSH/GSSG. Women with DOR compared to controls had higher level of TNF-α (P = 0.000) and lower level of IL-18 (P= 0.013). Correlation analysis revealed that GSSG was negatively correlated with normal fertilization ratein NOR group (r = -0.358, P = 0.008), and GSH was negatively correlated with normal fertilization rate in DOR group (r = -0.299, P = 0.049). Moreover, as the regression analysis data showed, the GSSG level was significantly associated with embryo quality indicator.
Conclusions
DOR was accompanied by increased oxidative stress and inflammatory levels in the FF. Follicular development of women with DOR might be influenced by unusual IL-18 level in the FF. And oxidative stress level in theFF contributed to embryo quality.
The mechanism by which ADAM10 cleaves Notch2 and upregulates RAB5 to regulate exosome secretion in pancreatic cancer
Authors: Xu Minxue , Ji Jie , Lin Renjie , Jin Dandan , Wu Tong , Huang Yuxuan , Qian Jiawen , Xu Weisong , Jiang Feng , Tan Zhonghua , Xiao Mingbing 
Published: July 2023

Abstract
Background
At present, the clinical diagnosis and treatment of pancreatic cancer (PC) are challenging, and there are still in gaps in the knowledge about its malignant progression. In particular, there is not enough information about the mechanism by which exosomes released by PC cells are significantly increased and involved in promoting malignant progression.
Results
In the present study, the expression of the metalloproteinase ADAM10 on cell membranes was found to be increased significantly in PC tissues and cell lines. Further, PC cells with high ADAM10 expression had stronger migration and invasion ability and were able to release more exosomes. Moreover, ADAM10 was found to affect the expression of RAB GTPase, a key regulatory molecule involved in the production of exosomes in cells, especially RAB5, which is associated with the formation of early endosomes. Further analysis indicated that ADAM10 may upregulate the transcription level of RAB5 by increasing the Notch2 signal intensity in PC cells, thus promoting the generation and secretion of exosomes in PC cells and further regulating the occurrence and development of PC.
Conclusions
These results reveal that ADAM10 plays a key role in regulating exosome secretion and may have potential as a therapeutic target for the clinical treatment of PC.