bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caution or risk：how institutional diversity impacts differently on foreign direct investment (FDI) amongst enterprises in the real and virtual economies？
Authors: Zhang Runze , Gao Meihong , Sun Jianguo 
Published: December 2022

Abstract
Over recent years successful development of the real economy has served as a pivot for China to “depart from the real to the virtual”. The Belt and Road Initiative (BRI) provides an opportunity for Chinese enterprises to achieve internationalization. Based on the diversity of institutions, a difference in difference in differences (DDD) model is constructed to analyze how investment motivations differ for real economy enterprises and virtual economy enterprises in countries that form part of the BRI. There are four main observations: (1) real economy enterprises tend to invest in countries that form part of the BRI and have mature markets and similar institutional environments. Furthermore, investment risks and transaction costs are contributary factors in enterprise decision-making in relation to the BRI; (2) real economy enterprises are more cautious towards foreign investment. Considering investment risks and transaction costs, they also focus on the influence of institutional diversity amongst countries; (3) virtual economy enterprises are instead motivated by return on capital when it comes to foreign investment. Investment risk and transaction costs have little impact on their decision-making; (4) foreign investment is also affected by cultural differences and geographical location, which has been promoted by the opening of the Maritime Silk Road.
Pan-cancer analysis of oncogenic BARX2 identifying its prognostic value and immunological function in Liver hepatocellular carcinoma
Authors: Yu Shi’an , Yang Yu , Yang Han’qing , Peng Long , Wu Zhi’peng , Sun Liang , Wu Zheng’yi , Yu Xu’zhe , Yin Xiang’bao 
Published: December 2022

Abstract
Transcription factor BarH-like homeobox 2 ( BARX2 ), a member of the Bar-like homeobox gene family,involved in cell proliferation, differentiation, immune response and tumorigenesis. However, the potential role of BARX2 in the development of Liver hepatocellular carcinoma ( LIHC ) remains unclear. Therefore, we aimed to study the biological role of BARX2 in hepatocellular carcinoma.Through UALCAN, GTEx PORTAL, TIMER 2.0, LinkedOmics, SMART, MethSurv, Metascape, GSEA and STRING public databases, the BARX2 mRNA level, prognostic value, co-expressed genes, differentially expressed genes, DNA methylation and functional enrichment analysis of LIHC patients were studied. The relationship between BARX2 expression and various clinical or genetic parameters of LIHC patients was determined using data from the Cancer Genome Atlas ( TCGA ), Gene Expression Omnibus ( GEO ), and BEAT LIHC databases. In addition, the biological function of BARX2 in LIHC was studied in vitro. Through large-scale data mining, our study shows that BARX2 is differentially expressed in different normal and tumor tissues. BARX2 expression in LIHC tissues was significantly lower than in the corresponding controls, especially in patients with T2-4 stage. In patients with LIHC, overexpression of BARX2 is an independent poor prognostic factor associated with poor cytogenetic risk and gene mutations. Genomic hypermethylation of the BARX2 gene was associated with upregulated BARX2 expression and low OS in LIHC. Functional enrichment analysis showed that BARX2 has an immunomodulatory role and inflammatory response in LIHC occurrence.In conclusion, the oncogene BARX2 may serve as a new biomarker and prognostic factor for patients with LIHC. the immunomodulatory function of BARX2 deserves further validation in LIHC.
GAS6-AS1, a long noncoding RNA, functions as a key candidate gene in atrial fibrillation related stroke determined by ceRNA network analysis and WGCNA
Authors: Li Rui-bin , Yang Xiao-hong , Zhang Ji-dong , Cui Wei 
Published: December 2022

Abstract

Background Stroke attributable to atrial fibrillation (AF related stroke, AFST) accounts for 13 ~ 26% of ischemic strokes. It has been found that AFST patients had greater disability and mortality than those without AF. Additionally, it’s still a great challenge to treat AFST patients because its exact mechanism at the molecular level remains unclear. Thus, it’s vital to investigate the mechanism of AFST and search for molecular targets of treatment. Long non-coding RNAs (lncRNAs) are related to the pathogenesis of various diseases. However, the role of lncRNAs in AFST remains unclear. In this study, AFST-related lncRNAs are explored using competing endogenous RNA (ceRNA) network analysis and weighted gene co-expression network analysis (WGCNA). Methods GSE66724 and GSE58294 datasets were downloaded from GEO database. After data preprocessing and probe reannotation, differentially expressed lncRNAs (DELs) and differentially expressed mRNAs (DEMs) between AFST and AF samples were explored. Then, a functional enrichment analysis and a protein-protein interaction (PPI) network analysis of the DEMs were performed. At the meantime, ceRNA network analysis and WGCNA were performed to identify hub lncRNAs. The overlap between hub lncRNAs identified by WGCNA and ceRNA network was further validated by Comparative Toxicogenomics Database (CTD). Results In total, 19 DELs and 317 DEMs were identified between the AFST and AF samples. Functional enrichment analysis suggested that the DEMs associated with AFST were mainly enriched in the activation of the immune response. Two lncRNAs were screened as hub lncRNAs by overlapping of the three lncRNAs identified by the ceRNA network and the 28 lncRNAs identified by WGCNA. Finally, lncRNA GAS6-AS1 turned out to be associated with AFST by CTD further validation. Conclusion These findings suggested that low expression of GAS6-AS1 might exert an essential role in AFST through downregulating its downstream target mRNAs GOLGA8A and Bach2, and GAS6-AS1 might be a potential target for AFST therapy.
Extracting events influencing anomalous behavior in stock market - A data driven approach using sentiment analysis
Authors: Sagar Som , M.S. Suchithra 
Published: December 2022

Abstract
Time series discrepancies can provide insight into critical situations affecting a company's stock. However, detecting the cause of anomalies in a time series data is particularly challenging due to the lack of datasets and highly complex temporal correlations. The recent advancement of internet technology has transformed the communications network, allowing the public to disclose knowledge such as news, social media contents, and so on via the internet, resulting in the exponential growth of web data. Massive amounts of publicly available data may hold the key to unveiling the financial market's unexplained anomalous behaviors. In this paper, a review is done on anomaly detection in stock market series data and a study is done on correlations between sentiments of news, tweets and opinions and stock price which shows collective news sentiments inversely affect stock price. Further we propose an lexicon based approach improved on a financial dataset for finding influencing factors of an anomaly period. Our analysis shows a strong correlation between the sentiment of our data and the stock price and were also successful in extracting major events that could have been cause of on anomaly.
Perineural adjuncts are superior to intravenous dexamethasone during a single shit nerve block in the shoulder under arthroscopy：a meta-analysis
Authors: Wu Rongcan , Chen Zhi , Chen Gang , Sun Jun , Liu Wenge 
Published: December 2022

Abstract
Purpose: Both perineural and intravenous routes of dexamethasone adminstration prolong the efficacy of a single interscalene brachial plexus block (ISB). However, the best route of administration remains a topic of debate.Our aim in this meta-analysis was to compare the efficacy and safety of perineural versus intravenous injection of dexamethasone in the treatment of ISB during arthroscopic shoulder surgery.
Methods: Relevant studies published before May 05 2021 were retrieved from PubMed, Embase, and Web of Science databases according to the preferred reporting items of the Systematic Evaluation and Meta-analysis (PRISMA) guidelines. The primary outcomes were duration of analgesia, sensory block,and motor block. The secondary outcomes included postoperative pain, opioid consumption and incidence of adverse events.
Results: Seven studies including 846 patients were identified. We found that, compared to the intravenous route,a perineural injection of dexamethasone significantly prolongs analgesia time (weighted mean difference[WMD]: 1.699 hours; 95% CI: 0.0014, 3.384; p=0.048) and reduces postoperative pain at 12 hours (WMD: -0.652; 95% CI: -1.129, -0.176; p=0.007). There was no significant difference between the two routes in the duration of sensory and motor block, postoperative pain and opioid consumption at 24 hours, and the incidence of adverse events (dyspnea, sleep disturbance, and postoperative glucose changes).
Conclusions: The current evidence demonstrates the superior effect of perineural dexamethasone for more prolonged analgesia and the reduction of acute postoperative pain.
Harnessing CD3 diversity to optimise CAR T cells
Authors: Minguet Susana , Cárdenas Rubí Velasco , Brandl Simon , Schlaak Emilia , Buschky Annabelle , Peters Timo , Beier Fabian , Serrels Bryan , Taromi Sanaz , Raute Katrin , Hauri Simon , Gstaiger Matthias , Lassman Silke , Huppa Johannes , Boerries Melanie , Andrieux Geoffroy , Bengsch Bertram , Schamel Wolfgang 
Published: December 2022

Abstract
Current FDA-approved CAR T cells harbour the TCR-derived ζ chain as intracellular activation domain. The contribution of the other chains of the TCR complex, namely CD3δ, CD3ε, and CD3γ in a CAR format remains unknown. Here, we have systematically engineered novel CD3-based CARs. Unexpectedly, CARs containing CD3δ, CD3ε or CD3γ cytoplasmic tails outperformed conventional ζ CAR T cells in vivo. Transcriptomic and proteomic analysis revealed differences in activation potential, metabolism and stimulation-induced T cell dysfunctionality that mechanistically explain the enhanced anti-tumour performance. Using these CARs as minimalistic and synthetic surrogate TCRs, we have identified the phosphatase SHP-1 as a new interaction partner of CD3δ that binds the CD3δ-ITAM upon phosphorylation of its C-terminal tyrosine. SHP-1 attenuates and restrains activation signals and might thus prevent exhaustion and dysfunction. These new insights into T cell activation could promote the rational redesign of synthetic antigen receptors to improve cancer immunotherapy.
Relationships Between Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease: Indication from Gut Microbiota Alterations
Authors: Zhang Pingchen , Huang Pei , Li Yuanyuan , Du Juanjuan , Luo Ningdi , He Yixi , Liu Jin , He Guiying , Cui Shishuang , Zhang Weishan , Li Gen , Shen Xin , Jun Liu , Chen Shengdi 
Published: December 2022

Abstract

Background Rapid eye movement sleep behavior disorder (RBD) has close relationship with Parkinson’s disease (PD), and even was regarded as the most reliable hallmark of prodromal PD. RBD might have similar changes in neuroimaging and gut dysbiosis to PD, but the relationship between RBD and PD in gut microbial alteration is rarely studied. In this study, we aimed to investigate whether there are the consistent changes between RBD and PD in gut microbiota, and find some specific biomarkers in RBD that might indicate phenoconversion to PD. Results This case-control study assessed microbiota of fecal samples from 35 idiopathic RBD (iRBD), 30de novoPD with RBD, 64 PD without RBD and 60 normal controls (NCs) by 16S ribosomal RNA amplicon sequencing (16S rRNA) and quantitative real-time PCR (qPCR). Alpha-diversity showed no remarkable difference and beta-diversity showed significant differences based on the unweighted (R = 0.035,P = 0.037) and weighted (R = 0.0045,P = 0.008) UniFrac analysis among four groups. Enterotype distribution showedRuminococcuswas dominant in iRBD, PD with RBD and PD without RBD, while NC wasBacteroides-dominant. 7 genera (4 increased:Aerococcus, Eubacterium,GordonibacterandStenotrophomonas, 3 decreased:Butyricicoccus, FaecalibacteriumandHaemophilus) were consistently changed in iRBD and PD with RBD. Among them, 4 genera (Aerococcus, Eubacterium,Butyricicoccus, Faecalibacterium) remained distinctive in the comparison between PD with RBD and PD without RBD.Butyricicoccus and Faecalibacteriumwere found negatively correlated with the severity of RBD, andStenotrophomonaswas found positively related to RBD disease duration. Functional analysis showed iRBD had similarly increased staurosporine biosynthesis to PD with RBD. Conclusions RBD has similar gut microbial changes to PD. DecreasedButyricicoccusandFaecalibacteriummight be specific to RBD, and also potential hallmark of phenoconversion of RBD to PD.
Three-Dimensional Anatomy of the Tibialis Anterior Tendon and its Clinical Implications for Tendon Rupture
Authors: Lee Hyung-Jin , Choi You-Jin 
Published: December 2022

Abstract
Purpose
The present study aimed to evaluate the precise three-dimensional (3D) insertion site of the tibialis anterior tendon and to compare the classification systems to identify potential differences between populations.
Methods
Seventy lower limbs were dissected. The tibialis anterior tendon was dissected to verify the insertion site to the medial cuneiform and the base of the first metatarsal bone. The 3D territory of the tibialis anterior tendon insertion on the medial cuneiform and the first metatarsal bones was measured on a reconstructed 3D model.
Results
The insertion pattern of the tibialis anterior tendon was classified into three types, the most common being Type I: a single tibialis anterior tendon dividing into two equal-sized bands to the medial cuneiform and base of the first metatarsal bone (57.1%, 40/70 of cases). The 3D territory of the tibialis anterior tendon was larger in the plantar aspect than in the medial side of both the medial cuneiform and the base of the first metatarsal bone. The tendon width at the medial cuneiform was wider than at the first metatarsal bone.
Conclusion
The tibialis anterior tendon was more commonly attached to the plantar part than the medial part in both the medial cuneiform and the base of the first metatarsal bone. The morphology of the tendon insertion was similar to that in Caucasian data. This anatomic information will help surgeons to perform anatomical reconstruction of the tibialis anterior tendon and reduce further tendon damage in the first metatarsocuneiform joint area.
Bursting Oscillation Process and Formation Mechanism of Doubly- fed Induction Generator
Authors: Chen Wei , Li Jiangtao , Wang Kun , Wei Zhanhong 
Published: December 2022

Abstract
This paper proposes an analytical method based on bifurcation theory and frequency domain fast-slow scale coupling to explain the oscillation process of a doubly-fed induction generator (DFIG) and its formation mechanism, in view of the bursting oscillation behavior of Doubly Fed Induction Generator (DFIG) when the system parameters vary under external disturbance. First, a mathematical model of the fourth-order generalized autonomous system of DFIG is established. Then, a two-parameter bifurcation diagram is introduced to study the bifurcation mechanism of the system when the internal parameters of the DFIG vary under external disturbance. To address the codim 2-bifurcation under the two-parameter variation, a three-dimensional overlay diagram is used to analyze the bursting oscillation process caused by the codim 2-bifurcation. In addition, the system operation is classified into three categories according to the bifurcation type of the two parameters. The oscillation state of the system when the DFIG is in different parameter ranges and the bifurcation type and formation mechanism causing bursting oscillation are analyzed using the equilibrium point distribution, transition phase, and timing diagrams. The research enriches the dynamic characteristics of the DFIG system and provides a theoretical basis for suppressing the bursting oscillation of the DFIG system.
‘Cut and push’ as an alternative to endoscopic retrieval of PEG type gastrostomy tubes
Authors: Claxton Harry , Dick Karen , Taylor Rhoda , Allam Maddie , Stedman Francesca , Keys Charlie , Hall Nigel J 
Published: December 2022

Abstract
Purpose:

Percutaneous Endoscopically placed Gastrostomy (PEG) tubes are frequently used in children. The traditional endoscopic method to remove/change the PEG device requires general anaesthesia in children. A minimally invasive alternative is the ‘Cut and Push’ method (C&P): avoiding the risks/wait times of general anaesthesia and reducing resource burden. Data regarding safety/effectiveness of C&P in children are lacking with concerns raised about the possibility of gastrointestinal obstruction.

Methods:

We retrospectively reviewed all cases of PEG removal / change to button in children (<18yrs) between December 2020 and January 2022. Cases were identified from a prospectively maintained database and all cases of C&P included. Parents/carers were asked if the child had suffered any complications following C&P and if flange was visualised in stools.

Results:

During the time period, 27 PEGs were either removed or changed to button via C&P. The average waiting time for C&P was 14.29 days, significantly shorter than the minimum 6 month waiting time for elective endoscopy. Our evaluation revealed no complications of C&P at median 70 days (range 25-301). In three cases the flange was visualised in the stool, at 2 days, 3 days and 5 weeksfollowing C&P respectively.

Discussion:

These data support the available literature suggesting C&P is an effective means to facilitate minimally invasive and prompt PEG removal / change to button in children. We recommend minimum weight and age parameters for this procedure and further evaluation of the safety and resource implications of this technique.
EstuarIndex: an eco-geomorphological index to assess the conservation state of estuaries
Authors: Aranda M. , Gracia F. J. , Peralta G. 
Published: December 2022

Abstract
The main objective of this work is to present a novel methodology to assess the vulnerability of mid-latitude estuaries by means of an index-based method, EstuarIndex. The EstuarIndexis an integration of four sub-indexes, assessing the status of the main subsystems present on estuaries: sandy environments, dunes, tidal flats, and the drainage network. Each sub-index includes variables combining three types of factors: morphosedimentary and oceanographic factors, ecological factors and management and protection factors. The environmental status is finally evaluated in five possible classes: (1) Very low, (2) Low, (3) Medium, (4) High and (5) Very High, according to EU requirements for classifying the conservation status of habitats. Three pilot zones along the Spanish coast have been chosen for testing the method: San Vicente de la Barquera estuary (N Spain), Guadiana estuary (SW Spain) and Ebro River delta mouth (E Spain). They present different oceanographic and geomorphological conditions. The results obtained have proven that EstuarIndex is a suitable methodology for the application to other estuaries. The systematic application of EstuarIndex on broad time scales would allow evaluating the system trends, what seems key for implementation of more realistic restoration strategies and may help in the detection of the most relevant site-specific vulnerabilities for long-term sustainability in response to both natural and artificial forces.
Mine water as a source of energy: an application in a coalfield in Laciana Valley (León, NW Spain)
Authors: Matas-Escamilla A. , Álvarez R. , García-Carro F. , Álvarez-Alonso L. , Cienfuegos P. , Menéndez J. , Ordóñez A. 
Published: December 2022

Abstract

Mine water can be a renewable and economical source of geothermal and hydraulic energy. Nine discharges from closed and flooded coal mines in the Laciana Valley (León, NW Spain) have been studied. Various technologies for the energy use of mine water, as well as the influence of factors such as temperature, the need for water treatment, investment, potential customers and expansion capacity, have been evaluated by means of a decision-making tool. It was concluded that the most advantageous option is an open-loop geothermal system using the waters of a mountain mine, the temperature of which exceeds 14ºC and whose distance to customers is less than 2 km. A district heating has been designed to supply, with technical-economic viability, heating and hot water to six public buildings in the nearby town of Villablino. The proposed use of mine water might help areas that have been greatly affected socio-economically by the closure of the mines and has other intangible advantages compared to conventional systems, such as the reduction of CO2emissions.
Research on Chaotic Image Encryption Method Based on Three Dimensional Linear Function
Authors: Yu Wanbo , Zeng Qinwu , Wang Wenqi , Xu Jianwei , Zeng Qingjian 
Published: December 2022

Abstract
Image as an essential carrier of data transmission, more and more people pay attention to its security. Although researchers have developed many encryption methods to enhance image transmission security, some have problems such as poor security, long-time complexity, and complicated algorithms. Therefore, this paper proposes a simple and secure encryption method. This method mainly combines chaotic systems with a three-dimensional(3D) linear function iterative system to encrypt images. First, a new chaotic system of 3D linear function iterations is constructed. Then, multiple 3D linear function iterative systems are invoked according to the sequences generated by the disorganized system iteration; finally, the chaotic lines generated by the 3D linear function iteration are operated with color images and gray images, respectively, by dissimilarity. The experimental results show that the scheme has a simple and efficient, low computational cost, good encryption effect, difficult to decipher, and strong key sensitivity encryption effect.
Variational Quantum Search with Exponential Speedup
Authors: Zhan Junpeng 
Published: December 2022

Abstract
With powerful quantum computers already built1,2, we need more efficient quantum algorithms to achieve quantum supremacy over classical computers in the noisy intermediate-scale quantum (NISQ) era2,3. Grover's search algorithm4,5 and its generalization, quantum amplitude amplification6, provide quadratic speedup in solving many important scientific problems7. However, they still have exponential time complexity as the depths of their quantum circuits increase exponentially with the number of qubits6,7. To address this problem, we propose a new algorithm, Variational Quantum Search (VQS), which is based on the celebrated variational quantum algorithms8,9 and includes a parameterized quantum circuit, known as Ansatz. We show that a depth-10 Ansatz can amplify the total probability of k (k≥1) good elements, out of 2n elements represented by n+1 qubits, from k/2n to nearly 1, as verified for n up to 26, and that the maximum depth of quantum circuits in the VQS increases linearly with the number of qubits. We demonstrate that a depth-56 circuit in VQS can replace a depth-270,989 circuit in Grover's algorithm, and thus VQS is more suitable for NISQ computers. We envisage our VQS could exponentially speed up the solutions to many important problems, including the NP-complete problems, which is widely considered impossible.