bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: Combination of veno-arterial extracorporeal membrane oxygenation and intra-aortic balloon pump in a young male patient with refractory cardiogenic shock due to aluminum phosphide poisoning
Authors: Dukhin Oleg , Bala Danila , Felker Evgeny , Golovina Polina , Tretyakova Mariya , Haes Boris , Savvinova Polina 
Published: September 2023

BackgroundAcute toxic myocardial damage may be accompanied by the development of cardiogenic shock (CS), the mortality from which is still unacceptably high. Since there is no specific antidote for many types of toxins, treatment of such patients includes various measures of hemodynamic and respiratory support. The paper presents a case of refractory CS due to possible aluminum phosphide (AP) poisoning.Case summaryA 20-year-old man was admitted to the emergency department 4 days after home inhalation of AP due to complaints of nausea, vomiting, abdominal and chest pain. Over the next few hours, he rapidly developed CS, which was refractory to conservative treatment. Therefore, veno-arterial membrane oxygenation (VA-ECMO) was performed, during which hemodynamics stabilized, but later there were signs of left ventricular overload. To unload the left ventricle (LV), an intra-aortic balloon pump (IABP) was implanted, which significantly improved the patient's condition. After 6 days the patient was decannulated, and a few more days later IABP was discontinued. Subsequently, the patient was treated for sepsis due to bilateral pneumonia and acute respiratory distress syndrome and optimal medical therapy for heart failure was prescribed. The patient was discharged after 34th day of hospitalization.
The lactate to albumin ratio linked to all-cause mortality in critically ill patients with septic myocardial injury
Authors: Chen Sheng , Guan Senhong , Yan Zhaohan , Ouyang Fengshan , Li Shuhuan , Liu Lanyuan , Zhong Jiankai 
Published: September 2023

BackgroundThe lactate to albumin ratio (LAR) has emerged as a promising prognostic marker in critically ill patients. Despite its potential utility, the prognostic value of LAR in septic myocardial injury (SMI) remains uncertain.MethodsThis study aims to investigate the prognostic significance of LAR in SMI through a retrospective cohort analysis of data from the Medical Information Mart for Intensive Care III (MIMIC-III) (v1.4) database. The study included intensive care unit (ICU)-admitted patients (age ≥18 years) diagnosed with SMI. The primary endpoint was in-hospital mortality.ResultsA total of 704 patients were included in the study, of which 59.10% were male. Hospital mortality and ICU mortality rates were recorded at 29.97% and 22.87%, respectively. After adjusting for confounding factors, multivariate Cox proportional risk analysis demonstrated that LAR was independently associated with an increased risk of both hospital mortality (HR, 1.39 [95% CI: 1.24–1.56] P &lt; 0.001) and ICU mortality (HR, 1.46 [95% CI: 1.29–1.65] P &lt; 0.001). Furthermore, the generalized additive model (GAM) and restricted cubic spline (RCS) model indicated a linear relationship between LAR and mortality rates in the ICU and hospital.ConclusionsThe LAR may serve as a potential prognostic biomarker in critically ill patients with SMI. High LAR levels are associated with a higher risk of in-hospital mortality and can help identify individuals with high mortality rates. Overall, the findings emphasize the importance of using LAR as a tool for risk stratification and management of critically ill patients with SMI.
Comparison of middle-term valve durability between transcatheter aortic valve implantation and surgical aortic valve replacement: an updated systematic review and meta-analysis of RCTs
Authors: Lerman Tsahi T. , Levi Amos , Jørgensen Troels Højsgaard , Søndergaard Lars , Talmor-Barkan Yeela , Kornowski Ran 
Published: September 2023

BackgroundThis study aims to compare valve durability between transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR).MethodsWe conducted a systematic review and meta-analysis using data from randomized controlled trials (RCTs). The primary outcome was structural valve deterioration (SVD). Secondary outcomes were bioprosthetic valve failure, reintervention, effective orifice area (EOA), mean pressure gradient, and moderate–severe aortic regurgitation (AR, transvalvular and/or paravalvular).ResultsTwenty-five publications from seven RCTs consisting of 7,970 patients were included in the analysis with follow-up ranges of 2–8 years. No significant difference was found between the two groups with regard to SVD [odds ratio (OR) 0.72; 95% CI: 0.25–2.12]. The TAVI group was reported to exhibit a statistically significant higher risk of reintervention (OR 2.03; 95% CI: 1.34–3.05) and a moderate–severe AR (OR 6.54; 95% CI: 3.92–10.91) compared with the SAVR group. A trend toward lower mean pressure gradient in the TAVI group [(mean difference (MD) −1.61; 95% CI: −3.5 to 0.28)] and significant higher EOA (MD 0.20; 95% CI: 0.08–0.31) was noted.ConclusionThe present data indicate that TAVI provides a comparable risk of SVD with favorable hemodynamic profile compared with SAVR. However, the higher risk of significant AR and reintervention was demonstrated.Systematic Review RegistrationPROSPERO (CRD42022363060).
The impact of female BMI on sperm DNA damage repair ability of oocytes and early embryonic development potential in intracytoplasmic sperm injection cycles
Authors: Jiang Yuqing , Shen Zhaoyang , Xu Jianmin , Zhu Jing , Wang Huan , Chen Wenhui , Sun Yingpu , Yang Qingling 
Published: September 2023

BackgroundObesity adversely influences the quality of oocytes and embryos and can affect DNA repair in embryos, leading to reproductive issues. However, the effects of body mass index (BMI) on DNA repair ability in oocytes during intracytoplasmic sperm injection (ICSI) cycles have not yet been investigated. Therefore, this retrospective study aimed to analyze the influence of sperm DNA damage on embryo development and reproductive outcomes in overweight/obese and normal-weight women in ICSI cycles.MethodsA total of 1,141 patients who received the first fresh ICSI cycle treatments were recruited from July 2017 to July 2021. Based on the BMI of the women, all patients were divided into normal weight (18.5≤BMI&lt;25 kg/m2; n=824; 72.22%) and overweight/obese (BMI≥25 kg/m2; n=317; 27.78%) groups. Furthermore, according to the sperm DNA fragmentation index (DFI), these two groups were subdivided into two subgroups: DFI&lt;30% and DFI≥30%.ResultsIn the normal-weight women group, the embryonic development and reproductive outcomes of ICSI cycles were not statistically different between the two subgroups (DFI&lt;30% and DFI≥30%). However, in the overweight/obese women group, couples with a sperm DFI≥30% had a significantly lower fertilization rate (76% vs. 72.7%; p=0.027), cleavage rate (98.7% vs. 97.2%; p=0.006), and high-quality embryo rate (67.8% vs. 62.6%; p=0.006) than couples with a sperm DFI&lt;30%.ConclusionWhen injected sperm with high DFI into the oocytes of overweight/obese women, resulting in lower fertilization, cleavage, and high-quality embryo rates in ICSI cycles, and the decreased early developmental potential of embryos from overweight/obese patients may be caused by the diminished capacity of oocytes to repair sperm DNA damage.
Effectiveness and potential mechanism of Jiawei-Xiaoyao-San for hyperthyroidism: a systematic review
Authors: Ma Wenxin , Zhang Xiaowen , Zhao Ruotong , Tang Yang , Zhu Xiaoyun , Liu Longkun , Xu Mingyuan , Wang Ge , Peng Peiyue , Liu Jianping , Liu Zhaolan 
Published: September 2023

ObjectivesTo evaluate the effectiveness and potential mechanism of traditional Chinese medicine Jiawei-Xiaoyao-San (JWXYS) as an adjunct or mono- therapy for antithyroid drugs (ATDs) in the treatment of hyperthyroidism.MethodsEight databases and three trial registries were searched from inception until May 2023. Randomized controlled trials (RCTs) were included and meta-analysis was conducted using RevMan 5.4 and Stata 14.0. The Cochrane risk of bias (ROB) tool 1.0 and GRADE tool was used for quality appraisal. The findings from case reports using mono-JWXYS and pharmacological studies were summarized in tables.ResultsThirteen RCTs with 979 participants were included. The majority of the included studies were assessed as high risk of bias in one ROB domain. Compared with ATDs, JWXYS plus ATDs resulted in lower free triiodothyronine (FT3) (MD = -1.31 pmol/L, 95% CI [-1.85, -0.76]; low-certainty), lower free thyroxine (MD = -3.24 pmol/L, 95% CI [-5.06, -1.42]; low-certainty), higher thyroid stimulating hormone (MD = 0.42 mIU/L, 95% CI [0.26, 0.59]; low-certainty), higher effectiveness rate of traditional Chinese medicine syndrome (RR = 1.28, 95% CI [1.08, 1.52]; low-certainty), lower goiter score (MD = -0.66, 95% CI [-1.04, -0.29]; very low-certainty), lower thyrotrophin receptor antibody (SMD = -0.44, 95% CI [-0.73, -0.16]; low-certainty) and fewer adverse events (AEs) (RR = 0.34, 95% CI [0.18, 0.67]; moderate-certainty). Compared with regular dosage of ATDs, JWXYS plus half-dose ATDs resulted in fewer AEs (RR = 0.24, 95% CI [0.10, 0.59]; low-certainty). Compared with ATDs in 1 trial, JWXYS resulted in higher FT3, lower goiter score and fewer AEs. Three case reports showed that the reasons patients sought TCM-only treatment include severe AEs and multiple relapses. Three pharmacological studies demonstrated that JWXYS restored Th17/Treg balance, lowered deiodinases activity, regulated thyroid cell proliferation and apoptosis, and alleviated liver oxidative stress in mouse or rat models.ConclusionJWXYS may enhance the effectiveness of ATDs for hyperthyroidism, particularly in relieving symptoms and reducing AEs. Mono-JWXYS is not recommended except in patients intolerant to ATDs. The findings should be interpreted with caution due to overall high risk of bias. Further pharmacological studies with more reliable models are needed.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023394923.
Re-examining the efficiency of the EU carbon futures market in phase Ⅱ: price discovery and intertemporal arbitrage
Authors: Xi Zili , Pan Huanxue , Qin Tao 
Published: September 2023

Introduction: Carbon futures market plays an important role in energy conservation and emission reduction of energy-intensive firms, and its efficiency is largely reflected by the dynamic relationship between carbon spot and futures prices. Even though the EU carbon futures market has undergone three phases, its efficiency in Phase Ⅱ still contains much controversy.Methods: Based on the cost-of-carry model, we apply linear and nonlinear Granger causality test, vector error correction model and threshold vector error correction model to re-examine the efficiency of the carbon futures market in the second phase of the European Union Emissions Trading System from the perspectives of price discovery and intertemporal arbitrage.Results: i) the EU carbon futures market has the function of price discovery by virtue of the broad scope of participants and the consequent huge liquidity, suggesting that the carbon futures price can predict the carbon spot price; ii) the coefficient requirement of the cost-of-carry model is satisfied and the relationship between the European Union Allowance (EUA) futures and spot prices is consistent with the cost-of-carry model, which indicates that the former is an unbiased estimator of the latter and an equilibrium relationship exists between the two prices so that the carbon futures market is efficient in the long run; iii) however, the carbon futures market shows inefficiency in the short run since it has an error correction function only when the basis is less than −0.07 and the carbon futures price indicates a remarkably slow adjustment to the long-run equilibrium when there is deviation, which can be ascribed to the global financial crisis as well as its aftermath in 2008.Discussion: In the context of global warming and carbon neutrality, the results of this paper are of great significance to emitters, arbitrageurs, hedgers and policymakers in emerging and young carbon markets.
Sequential extraction procedure of municipal solid waste incineration (MSWI) bottom ash targeting grain size and the amorphous fraction
Authors: De Matteis C. , Mantovani L. , Tribaudino M. , Bernasconi A. , Destefanis E. , Caviglia C. , Toller S. , Dinelli E. , Funari V. 
Published: September 2023

Introduction: Bottom ash (BA) constitutes a significant by-product obtained during the incineration of municipal solid waste in waste-to-energy (WtE) plants. BA is a heterogeneous material made of different fractions, glass, minerals, metals, and unburned residual organic matter. Due to the non-hazardous nature of the unburned material, BA can be effectively recycled, becoming a valuable resource. However, BA displays a high content of potentially toxic elements (PTEs) within its finer grain size. The presence of these elements raises concerns regarding the potential toxicity associated with BA.Materials and methods: The release of PTEs in the smaller fraction (0.063–0.2 mm; 0.3–0.5 mm; 2–4 mm; bulk &lt;4 mm) of BA collected from the Parma WtE plant was investigated using a new five-step sequential extraction procedure (SEP). Through this method, both leached solutions and solid residues were analyzed by inductively coupled plasma-mass spectroscopy (ICP-MS), X-ray powder diffraction (XRPD), and X-ray fluorescence (XRF) analysis. This integrated approach provided valuable insights into the mineralogy, chemical composition, and PTEs leachability of BA.Results and discussion: The novelty of this work is the development of a new SEP protocol specifically designed and planned for an anthropogenic material such as BA. The weight reduction recorded after each step is linked to the progressive disappearance of both crystalline and amorphous phases. Water-soluble phases, such as salts, are the first to react, followed by the carbonate fraction in the second step. At the end of the procedure, only quartz, corundum, and Ti-oxide are identified. Among the PTEs, Pb exhibits the highest release, particularly during the acid attack, followed by Zn. The significant release of Ni during the oxidizing and reducing steps can potentially be linked to hydroxides and metallic alloys, respectively. The integration of XRF and Rietveld refinement results on solid residues enabled the identification of several types of amorphous materials and their chemical evolution during the sequential extraction.
What determines demographic growth in green anacondas? Strong interactions among vertebrates in a neotropical ecosystem
Authors: Rivas Jesús A. , Jaremko-Wright Will 
Published: September 2023

IntroductionTrophic cascades can produce important effects on a community where some species may have strong effects on other parts of the community up, down the food chain, or both. Top predators are often controlled from the bottom-up by the abundance of their prey base while prey animals are often controlled from the top-down. Studies of trophic interactions in the tropics suggest that the trophic chains are longer because of the high productivity; and because of the high diversity there is abundant intraguild redundancy which results in weak interactions.MethodsWe studied the effect of bottom-up forces affecting the population of green Anaconda (Eunectes murinus) in the Venezuelan llanos; looking at net primary productivity, precipitation, and the abundance of an important prey item, Capybara (Hydrochaeris hydrochaeris).ResultsOur data show a strong interaction of these variables on the percentage of Anacondas that reproduce in a given year (here forth breeding ratio). In particular Capybara abundance has a strong effect. Capybara abundance itself is also under strong bottom-up influence determined by precipitation and Net Primary Productivity.DiscussionThese strong interactions are not what is expected from a tropical ecosystem. We also found an unexpected strong influence of precipitation and primary productivity on Anaconda breeding ratio not related to the abundance of Capybara, likely affecting abundance of other prey or affecting non-trophic variables. This later evidence supports the notion that there is redundancy in tropical food chains and, strong as the effect of Capybara abundance might be, Anacondas do not entirely rely on them.
Identifying target ion channel-related genes to construct a diagnosis model for insulinoma
Authors: Mo Shuangyang , Wang Yingwei , Wu Wenhong , Zhao Huaying , Jiang Haixing , Qin Shanyu 
Published: September 2023

Background: Insulinoma is the most common functional pancreatic neuroendocrine tumor (PNET) with abnormal insulin hypersecretion. The etiopathogenesis of insulinoma remains indefinable. Based on multiple bioinformatics methods and machine learning algorithms, this study proposed exploring the molecular mechanism from ion channel-related genes to establish a genetic diagnosis model for insulinoma.Methods: The mRNA expression profile dataset of GSE73338 was applied to the analysis, which contains 17 insulinoma samples, 63 nonfunctional PNET (NFPNET) samples, and four normal islet samples. Differently expressed ion channel-related genes (DEICRGs) enrichment analyses were performed. We utilized the protein–protein interaction (PPI) analysis and machine learning of LASSO and support vector machine-recursive feature elimination (SVM-RFE) to identify the target genes. Based on these target genes, a nomogram diagnostic model was constructed and verified by a receiver operating characteristic (ROC) curve. Moreover, immune infiltration analysis, single-gene gene set enrichment analysis (GSEA), and gene set variation analysis (GSVA) were executed. Finally, a drug–gene interaction network was constructed.Results: We identified 29 DEICRGs, and enrichment analyses indicated they were primarily enriched in ion transport, cellular ion homeostasis, pancreatic secretion, and lysosome. Moreover, the PPI network and machine learning recognized three target genes (MCOLN1, ATP6V0E1, and ATP4A). Based on these target genes, we constructed an efficiently predictable diagnosis model for identifying insulinomas with a nomogram and validated it with the ROC curve (AUC = 0.801, 95% CI 0.674–0.898). Then, single-gene GSEA analysis revealed that these target genes had a significantly positive correlation with insulin secretion and lysosome. In contrast, the TGF-beta signaling pathway was negatively associated with them. Furthermore, statistically significant discrepancies in immune infiltration were revealed.Conclusion: We identified three ion channel-related genes and constructed an efficiently predictable diagnosis model to offer a novel approach for diagnosing insulinoma.
Rare solid tumors in a patient with Wiskott–Aldrich syndrome after hematopoietic stem cell transplantation: case report and review of literature
Authors: Coppola Emma , Giardino Giuliana , Abate Massimo , Tambaro Francesco Paolo , Bifano Delfina , Toriello Elisabetta , De Rosa Antonio , Cillo Francesca , Pignata Claudio , Cirillo Emilia 
Published: September 2023

Background and aimsWiskott–Aldrich syndrome (WAS) is an X-linked recessive primary immunodeficiency disorder characterized by severe eczema, recurrent infections, and micro-thrombocytopenia. Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapeutic option for patients with classic form. The risk of developing post-transplant tumors appears to be higher in patients with WAS than in other inborn errors of immunity (IEIs), but the actual incidence is not well defined, due to the scarcity of published data.MethodsHerein, we describe a 10-year-old patient diagnosed with WAS, treated with HSCT in the first year of life, who subsequently developed two rare solid tumors, kaposiform hemangioendothelioma and desmoid tumor. A review of the literature on post-HSCT tumors in WAS patients has been performed.ResultsThe patient received diagnosis of classic WAS at the age of 2 months (Zhu score = 3), confirmed by WAS gene sequencing, which detected the nonsense hemizygous c.37C&gt;T (Arg13X) mutation. At 9 months, patient underwent HSCT from a matched unrelated donor with an adequate immune reconstitution, characterized by normal lymphocyte subpopulations and mitogen proliferation tests. Platelet count significantly increased, even though platelet count never reached reference values. A mixed chimerism was also detected, with a residual WASP− population on monocytes (27.3%). The patient developed a kaposiform hemangioendothelioma at the age of 5. A second abdominal tumor was identified, histologically classified as a desmoid tumor when he reached the age of 10 years. Both hematopoietic and solid tumors were identified in long-term WAS survivors after HSCT.ConclusionHere, we describe the case of a patient with WAS who developed two rare solid tumors after HSCT. An active surveillance program for the risk of tumors is necessary in the long-term follow-up of post-HSCT WAS patients.
Dermatological concerns for women and girls with turner syndrome
Authors: Rodriguez-Buritica David , Mones Meaghan , Prakash Siddharth K. , Rivera Michelle , Aldrich Melissa , Rogge Megan , Richardson Kate 
Published: September 2023

IntroductionTurner syndrome (TS) is associated with distinct manifestations in women and girls including short stature, cardiac abnormalities, premature ovarian failure as well as dermatological features, including lymphedema, keloids, onychodystrophy, and acne. Although many dermatological concerns present during the first few decades of life, the overwhelming majority of respondents are not provided with dermatology referrals at diagnosis.MethodsThis cross-sectional study utilized an author designed survey to assess self-reported dermatological manifestations, dermatology referral experience, common therapies for select dermatological conditions, as well as a validated 10-question Dermatology Life Quality Index (DLQI) to assess quality-of-life impact in women and girls with Turner syndrome.ResultsIn our cohort, 64% (n = 149) had been referred to a dermatologist at some point in their life time. The majority of individuals self-identified their dermatological concern (79.6%) and were referred after a dermatological concern had already occurred (90.2%). The most common dermatological findings reported were xerosis cutis (78.7%), lymphedema (73%), and more than 20 acquired melanocytic nevi (70%). The overall mean DLQI score was 3.52, indicative of a small effect on the patient’s life. Onychodystrophy, history of skin biopsy, and lymphedema were statistically significant to have a higher impact on quality of life.DiscussionOur data reveal that skin conditions are highly prevalent in the TS population during the early decades of life and affirm utilizing these conditions in the TS diagnostic process, as well as emphasize the need for specialized dermatology referrals to address the detrimental impacts related to skin concerns on quality of life.