bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pupillographic Analysis of COVID-19 Patients: Early and Late Results After Recovery
Authors: Gunduz Gamze Ucan , Yildiz Aysegul Mavi , Yalcinbayir Ozgur , Baykara Mehmet , Sari Esin Sogutlu , Isleker Sevde , Ozturk Nilufer Aylin Acet 
Published: April 2023

Abstract
Purpose: We aimed to investigate the short and long-term static and dynamic pupillary responses of patients recovered from coronavirus disease – 19 (COVID-19) by using quantitative infrared pupillography.
Methods: This study included patients who recovered from COVID-19 (Group 1) and age- and gender-matched controls (Group 2). A detailed ophthalmic examination was performed at one month and six months after the diagnosis of COVID-19. Photopic, mesopic, and scotopic pupil diameters (PDs) were measured by using a quantitative infrared pupillography which was integrated into Scheimpflug/Placido photography-based topography system. Pupil diameters at 0, 2nd, 4th and 6th seconds, and average pupil dilation speeds at 2nd, 4th, 6th and 8th seconds were recorded.
Results: Eighty-six eyes of 86 patients (Group 1: n=42; Group 2: n=44) were included. While the mean photopic, mesopic and scotopic PDs were significantly larger in the COVID-19 group than the control group in the first month (p = 0.035, p = 0.017, p = 0.018, respectively), no statistically significant difference was found in the sixth month. Besides, average pupil dilation speeds and PDs at the 0, 2nd, 4th and 6th seconds were not statistically significantly different between the two groups in the first month and sixth month.
Conclusions: Pupil diameters were significantly larger in COVID-19 patients in all light intensities in the first month after COVID-19. However, pupillary dilation was transient, and no significant difference was found in the sixth month. We suggest that the transient pupillary dilation may be secondary to the autonomic nervous system dysfunction following COVID-19.
Smart Contract-based Dynamic Non-Fungible Tokens Generation System
Authors: Shah Kaushal , Khokhariya Uday , Patel Saumya 
Published: April 2023

Abstract
Digital assets backed up by blockchain technology are termed Non-Fungible Tokens (NFTs). Every NFT is uniquely identified by its metadata, stored in the smart contract. This metadata can consist of associated images, descriptions , attributes, and other relevant details in a JavaScript Object Notation (JSON) object. Most of these NFTs are static; therefore, their metadata remains immutable. Due to rising blockchain use cases like real-world token regulation and blockchain-based ticketing platforms, a need arises to modify the existing metadata and require interaction for community engagement. Here, Dynamic NFTs (DNFTs) bring the notion of adding upgradeability and interactivity to existing NFTs. We propose a DNFT generation system built on top of decentralized oracle networks and utilizing on-chain metadata using smart contracts, which could be used as a base for future dynamic NFT generation models. Furthermore , we are bringing the web2 equivalent experience to viewable content, which can be used for ad spaces and real-time messaging in the form of NFTs. Henceforth, we are augmenting NFTs for versatile use cases, such that they are more than just static assets.
Influence mechanism of paper mechanical properties: numerical simulation and experimental verification based on a fiber network
Authors: Li Haojin J. , Sun Hao , Wei Lingjun , Zhu Yunfeng , Wang Yaling , Zhang Wanlu 
Published: April 2023

Abstract
As a kind of renewable material that is widely available, paper is applicable in various fields. However, the research on its properties focuses mainly on macro mechanical properties, which ignores the micro theory based on the interface of paper. In essence, paper is a microscopic network made up of interrelated fibers. In this paper, a comprehensive experimental and computational study was conducted on the mechanical properties of the fiber and the fiber network, with consideration given to the impact of microstructure. A beam-spring model was established by using the beam fiber network. Then, simulations were performed on exemplary fiber network samples to demonstrate the impact of fiber microparameters on their mechanical properties, such as the force-elongation curve and strength. It was revealed through mechanical experiments that the tensile strength in the Z-direction (fiber bond strength) had a more significant impact on the properties of paper than the zero spacing tensile index (fiber strength), which is highly consistent with the result of modeling. All the simulation results were validated by performing experimental measurement. Finally, computational insights were gained into the pattern of interfiber bond damage on different fiber microlevels. To sum up, the proposed beam-spring model was demonstrated as applicable to predict the response from the fiber networks of paper materials.
The interplay of 'twin nutrients' (vitamin D and boron) in an allegedly understated anthropometric status (stunting, anaemia, malnutrition) that refuses to improve - missing links, missed opportunities and actionable lessons from the field of veterinary medicine
Authors: Patil Pradeep B. , Jaleel Abdul , Qadri SSYH 
Published: April 2023

Abstract
Background: Despite various measures taken by governments, the lack of significant improvements in malnutrition status remains a troubling issue, causing concern for implementing agencies and the biomedical community worldwide. Interestingly, similar issues have also emerged in the veterinary sector in recent decades, particularly in dairy, poultry, piggery, and goat farming. As a result, research in veterinary medicine has been conducted on a war footing because the welfare of animals, farmer profitability, and human health have been at stake. This manuscript aims to understand the mystery of anthropometric failure in humans through an interdisciplinary perspective.
Methods: To investigate the missing links between nutrients, hormones, and anthropometrics, a literature search was conducted using the databases 'PubMed' and 'Google Scholar' with various related keywords to find unexplored causes of malnutrition. The obtained data was further analysed with the aim of identifying the missing links. The keyword search was then narrowed down to 'vitamin D' and 'Boron' based on the hypothesis that they could be considered as 'common but natural constituents other than food'. To substantiate, data from the Indian population, including CNNS and NFHS-5, were analysed.
Findings: The hypothesis that 'paired deficiency statuses' (Vitamin D and Boron deficiency) lead to a 'cascade effect' on 'deteriorating anthropometric values' (such as the hunger index) appears to be supported by the results of the comparative review of multi-disciplinary literature and derived data analysis.
Interpretation: Prompt intervention to revise the supplementation and fortification dosage of vitamin D and boron could lead to improvements in anthropometric values. However, to address the issue effectively, it is crucial to clarify the definitions of deficiency and toxicity. In the long run, efforts to enhance ‘soil organic carbon’ could serve as a sustainable solution for ‘triple burden of malnutrition’ in India.
Funding: The PP research is supported by ICMR-NIN intra-mural grant (20-NINAF03).
The effect of dry needling compared to lumbar spine mobilization on functional disability, pain, quadratus lumborum and lumbar multifidus function, lumbar range of motion and pain pressure threshold in patients with non-specific chronic low back pain: Study protocol for a randomized controlled trial
Authors: mirzaie hamide , Pourahmadi Mohammadreza , Ayoubpour Mohamad reza , Firouze Bahare 
Published: April 2023

Abstract
Background: Low back pain (LBP) is a socioeconomic burden worldwide and a major contributor to health-care costs. Mobilization and dry needling (DN) are well-known treatments for LBP, and both of them, as a part of treatment, can relieve LBP.
Objective: Due to the importance of choosing interventions with greater effects on patients' recovery, in this study we intend to compare DN and lumbar spine mobilization, as complementary therapies in combination with routine physical therapy in the treatment of patients with chronic non-specific LBP.
Methods and study design: The study is a two-arm randomized, double-blind, double-dummy, controlled trial comparing DN to lumbar spine mobilization in individuals (n=56; 18–45 years of age) with chronic non-specific LBP. The experimental group will receive DN plus sham mobilization and the control group will receive Maitland’s posterior-anterior mobilization plus sham DN. Both groups will receive exercise and low-power laser. The primary outcome is functional disability, and the secondary outcomes are pain, lumbar multifidus and quadratus lumborum function, lumbar range of motion, pain pressure threshold, DN side effects, and patient adherence to treatment. Each group will receive 8 treatment sessions during 4 weeks (2 treatment sessions per week). Primary and secondary outcomes will be assessed at baseline and 3 to 7 days after the final treatment session. A mixed-model (ANCOVA) for each dependent variable will be used All the study’s processes including recruitment, primary measurement, treating patients and final measurement will be completed in 5 to 6 months.
Discussion: In this study, we intend to solve the methodological problems of the previous study in this field. The results of this study allow the therapist to choose an intervention that has more therapeutic effects in combination with routine physiotherapy in the treatment of patients with chronic non-specific LBP.
Trial registration: 1) ClinicalTrials.gov registration number: NCT05214456. (date: 01/15/2021) 2) IRCT.ir registration number: IRCT20210706051802N1 (date: 04/27/2022).
Pathways to mental health treatment: biomedical versus faith- healing
Authors: Badu Eric , Mitchell Rebecca , Gu Jun , O’Brien Anthony Paul 
Published: April 2023

Abstract
Background Understanding the pathways to mental health treatment is important to inform service outcome, yet limited empirical research has been conducted. This paper explores the pathways used to treat mental illness in Ghana from the perspective of consumers and mental health professionals (MHPs).Methods The paper used a qualitative method, involving in-depth interview with 30 mental health professionals and 21 consumers, selected through purposive sampling. The data were transcribed and analysed using thematic analysis.Results The findings indicate that mental illness is treated using biomedical, faith based and traditional healing services. Faith and traditional healing pathways are typically used as a preliminary source or first point of care before seeking biomedical treatment. The decisions regarding treatment pathways are influenced by predisposing factors, particularly belief systems and attitudes, as well as enabling factors including acceptability. The study also found an increasing informal collaboration between faith and biomedical practitioners and call for more formalised integration of the existing mental health system.Conclusion The existing interest and knowledge on faith-healing services should be formalise for policy re-formulation, and further integrated into curriculum design for training mental health professionals. Current collaboration and education provided to faith-healing providers, should be promoted, and integrated into the mental health systems.
Effect of altitude and slope on the germination and growth of blue pine (Pinus wallichiana A. B. Jacks.) in reference to stratified and non-stratified seeds
Authors: Kaur Amanpreet , Bhardwaj D. R. , Monga Rajesh 
Published: April 2023

Abstract
During the present study, the impact of cold stratification at different elevations and angles on the germination and growth characteristics of white pine (Pinus wallichiana A. B. Jacks.) seedlings were examined. In the years 2019–20, seeds were gathered in Himachal Pradesh from several altitudinal ranges [1800–2100 (A1), 2100–2400 (A2), 2400–2700 (A3), and > 2700 (A4) m.a.s.l] and aspects [southern aspect (As1), eastern aspect (As2), and south-eastern aspect (As3)]. The nursery was established in 2020 at the Dr. Y.S. Parmar University of Horticulture and Forestry, Nauni, Solan (HP), Department of Silviculture and Agroforestry Forest Nursery. After being sun-dried, the cones were manually shaken and twisted to release the seeds. To break their dormancy, seeds were stratified with various layers of sand and moss for around 60 days before sowing. Seed viability (78.9% in S, 63.1 in NS), germination percentage (84.3% in S, 80.8 in NS), seedling height (11.7 in S, 9.22 cm in NS), survival percentage (71.3% in S, 59.6% in NS), and other growth traits of stratified (S) and non-stratified (NS) seeds were found to be significantly higher in stratified seeds collected from lower altitudinal ranges. Based on the findings, it was concluded that cold stratification of seeds obtained from lower altitude sites was suitable for extensive planting owing to their higher vitality and overall superior health.
The Anti-Tumoral Role of Hesperidin and Aprepitant on Prostate Cancer cells through Redox Modifications
Authors: Akbari Sanaz , Darban Reza Assaran , Javid Hossein , Esparham Ali , Hashemy Seyed Isaac 
Published: April 2023

Abstract
Introduction: Prostate cancer is the second most frequent cancer in men. Aprepitant (AP) is a highly specific NK1R antagonist and its anti-cancer effects against different cancer cells including prostate cancer are shown previously. Also, the anti-cancer effect of Hesperidin has been shown in prostate cancer cells. While the anti-cancer effect of Hesperidin and AP on prostate cancer cells is well documented, their combined effect, as well as their mechanism of action are not fully understood. Therefore, the present study aimed to investigate the anti-cancer effects of Hesperidin and AP alone and in combination on prostate cancer cells.
Method: PC3 and LNCaP cell lines were treated with Hesperidin and AP alone and in combination. The Resazurin test was used for assessing cell viability. The ROS (reactive oxygen Species) level, P53 and P21 gene expression, and Bcl-2 and Survivin gene expression were assessed in both cell lines. Also, a trypan blue assay was done for both cell lines.
Results: The results of Resazurin showed that Hesperidin and AP significantly reduce the cell viability of PC3 and LNCaP cell lines. The ROS level significantly reduced after treating the PC3 and LNCaP cells with 10 µM AP with or without Hesperidin pretreatment. P53 and P21 gene expression significantly increased after treatment with 50 and 100 µM Hesperidin with or without 10 µM AP compared to the untreated group in the PC3 cell line. In addition, Bcl-2 and Survivin gene expression significantly decreased with 10 µM AP with or without Hesperidin pretreatment in the PC3 and LNCaP cell lines. Also, the results of the trypan blue assay showed the combination of Hesperidin with AP induced a high rate of apoptosis in LNCaP and PC3 cell lines.
Conclusion: The current study showed the synergic anti-cancer effect of Hesperidin and Aprepitant on prostate cancer cells in both PC3 and LNCaP cell lines
Hybrid QAOA and Genetic Algorithm for Solving Max-Cut Problem
Authors: Ha Huy Phuc Nguyen , Ta Anh Son 
Published: April 2023

Abstract
Quantum Approximate Optimization Algorithm (QAOA) is one of the variational quantum optimizations that is used for solving combinatorial optimization. The QAOA calculates the average of all solutions provided by the quantum circuit. To improve the result, we investigate a new method to combine QAOA and genetic algorithms. The result of QAOA is considered as an initial population method for a genetic algorithm. This approach is applied to solve the max-cut problem, which is very important for quantum computing research. This method is applied to benchmark datasets and the results have been improved significantly.
Synergistic effects of royal jelly and melittin on wound healing and collagen synthesis in mouse skin
Authors: Zarei Seyedemaryam , Eidi Maryam , Ebrahimi-kia Yasaman , Pazoki Zahra , Parhizkari Narges , Mohajer Zohreh 
Published: April 2023

Abstract
Since ancient times, bees and their products have been traditionally used in the treatment of many diseases, but the synergistic effects of bee products such as royal jelly (RJ) and melittin in the treatment of skin damage are an important issue due to its availability and cheapness. In this study, a 5 mm diameter wound was created by punching the skin on the back of the neck in NMARI male mice. Wounds were treated orally and topically with different doses of RJ and melittin and their combination for 9 days. The diameter of the wounds was measured and recorded daily, and on the 10th day, the mice were anesthetized and their skin tissue samples were taken for histological examinations and hydroxyproline measurement. Histopathological sections were evaluated for the presence of fibroblasts, new blood vessels, epithelial tissue formation, collagen synthesis, presence of inflammatory cells. Synergistic effects of oral treatment with RJ (50 mg/kg) and melittin (3x10− 5 mg/kg) and combined topical treatment of RJ (2.5%) and melittin (0.5x10− 4%) caused a significant reduction in the diameter of the skin wound compared to a single dose of them. The findings of biochemical studies showed a significant increase of hydroxyproline level in the wound tissue in the group treated with RJ and melittin topically and orally compared to the control group. The synergistic effect of RJ and melittin in collagen synthesis in the skin of could confirm the use of these materials in the traditional and modern medicine for skin treatments.
Impact of Body Mass Index on postoperative pain and opioïd administration after pressurized intraperitoneal aerosol chemotherapy (PIPAC) in the treatment of peritoneal carcinomatosis.
Authors: Tidadini Fatah , Trilling Bertrand , Quesada Jean-Louis , Abba Julio , Foote Alison , Faucheron Jean-Luc , Arvieux Catherine 
Published: April 2023

Abstract
BACKGROUND Intraperitoneal aerosol spray chemotherapy (PIPAC) is a new surgical technique, developed for the treatment of peritoneal carcinomatosis (PC). In this retrospective observational study we assessed the impact of body mass index (BMI) on postoperative pain and opioid consumption.METHODS We analysed pain scores after 100 PIPAC procedures with either oxaliplatin or doxorubicin-cisplatin performed in 49 patients with PC between July 2016 and September 2020. The patients were divided into 4 groups (BMI < 18.5, 18.5 ≥ BMI < 25, 25 ≥ BMI ≤ 29.9 and BMI ≥ 30). Pain was self-rated on a visual analogue scale (VAS) from 0 to 10.RESULTS Univariate logistic regression analysis identified oxaliplatin to be associated with moderate to severe pain (VAS 4–10 at 8h D1) before (OR [95% CI]; 3.75[1.33–10.54]; p = 0.012) and after adjustment (OR [95% CI]; 4.13[1.41–12.11] p = 0.010) on BMI. The level of pain appeared significantly different between the treatment groups (median 2.5[0; 5] vs 0[0; 2.5] p = 0.0017) irrespective of BMI (p = 0.46 and p = 0.226). Multivariate logistic regression analysis identified moderate to severe pain and synchronous PC to be associated with greater use of opioids (OR [95% CI]: 3.91 [1.24–12.32]) and (OR [95% CI]: 5.16 [1.71–15.58]; respectively. Opioids were administered after 45 procedures (45%) and was comparable between the treatment groups. Opioid administration and length-of-stay were similar among BMI bands.CONCLUSION We conclude that BMI is not related to postoperative pain or opioid use and that moderate to severe pain and synchronous PC are factors associated with requiring opioïds.
Fuzzy Logic Control of an Automatic Changeover for the Management of a Grid-Connected Photovoltaic System
Authors: Dandoussou Abraham , Kenfack Pierre 
Published: April 2023

Abstract
The main objective is to design a smart switch controlled using fuzzy logic which is able to take decisions on the different sources of energy in a very brief ‘switching time’ to avoid load shedding. For that, a fuzzy controller is implemented by considering input signals from three power sources: Photovoltaic array, batteries and grid. The inputs are: irradiance being the instantaneous measurement of solar energy, voltage range for the power grid and state of charge for the battery to be able to know if the battery can supply or not. For these corresponding inputs, Takagi’s fuzzy inference system was applied, that permitted to have linear constant as outputs. As such able to control the switch with respect to the source available at a particular period of the day, either day or night. Designing the fuzzy logic controller was able to take decisions with respect to the conditions. The load feeding signal behaviour has been obtained when either of the switches are open or closed over a period of 1000s. In this system the batteries charge is either done by the PV array or the power grid according to the established rules of the system.
Two cases of gastrointestinal tumor with uterine cervical metastases: a case report
Authors: Xie Jiayuan , Wu Wenhui , Zhang Hua , Yang Huan , Guo Xue , Zhao Tingting , Zhang Changlin , Li Tian 
Published: April 2023

Abstract
Background: Gastrointestinal (GI) tumors are among the most prevalent malignant tumors worldwide. Recurrence and metastasis remain the leading causes of advanced GI tumor-related mortality. We present two rare cases of uterine cervical metastases from GI tumors and describe the clinical and pathological diagnosis, therapeutic options, and prognosis from a molecular biology perspective.
Case presentation: We present the case of a 55-year-old Asian woman treated for sigmoid adenocarcinoma. The patient underwent a sigmoid colon resection without chemotherapy. Six months later, the tumor in the patient’s pelvis recurred, and she underwent pelvic lesion resection and bilateral adnexectomy. The patient underwent frequent chemotherapy, radiotherapy, targeted therapy, and immunotherapy after surgery. Five years later, the patient was diagnosed with intestinal cancer and cervical metastasis due to vaginal bleeding. Another case involved a 54-year-old Asian woman with poorly differentiated adenocarcinoma of the stomach who underwent radical gastrectomy, left adnexal metastasis 1 year later, and bilateral adnexectomy. After surgery, insufficient chemotherapy was administered, and a year later, vaginal bleeding revealed metastatic adenocarcinoma of the cervix.
Conclusions: Although cervical metastases from gastrointestinal tumors are rare, physicians should be aware of this risk. According to these guidelines, surgical resection is necessary for isolated cervical metastases, and systemic treatment is preferred if multiple metastases are present. However, in the present case, surgery was performed despite multiple metastases, which prolonged the patient's survival and improved the quality of life. Treatment options should be individualized. It has been suggested that such patients undergo genetic testing to facilitate targeted drug selection and improve treatment outcomes.
Demicompact Linear Relations
Authors: Ammar Aymen , Daoued Houcem , Jeribi Aref 
Published: April 2023

Abstract
In this paper, we give new results on demicompact linear relations, we study some properties and some results on Fredholm and upper semi-Fredholm relations involving demicompact relations. Our results are used to establish a ne description of the essential spectrum and essential pseudospectrum of a linear relation.
Subject Classications (2000) : 47A06