bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of inclusion of post-spermatic ejaculate fraction in boar seminal doses on sperm metabolism, quality, and interaction with uterine fluid
Authors: Luongo Chiara , Llamas-López Pedro José , Garrappa Gabriela , Rodríguez-Tobón Ernesto , Grudzinska Paulina , García-Vázquez Francisco Alberto 
Published: September 2023

AbstractBoar ejaculate is composed of sperm cells and seminal plasma (SP) and is emitted in different fractions (pre-sperm fraction; spermatic-rich fraction; intermediate fraction; post-spermatic fraction), with different composition of SP and volume, which could influence the sperm quality during seminal doses preparation, conservation, and interaction with the female reproductive tract. In artificial insemination (AI) centers, seminal doses are usually prepared with the spermatic-rich and intermediate fractions, but the inclusion of other ejaculate fractions, although controversial, is beginning to be applied. The objective was to evaluate the synergic effect of accumulative ejaculated fractions on sperm functionality during seminal doses preparation, throughout storage and after incubation with uterine fluid (UF). For this purpose, a total of 57 ejaculates were collected, and the following experimental groups were prepared (n = 19 per group): (F1) spermatic-rich fraction; (F2) F1 plus intermediate fraction; (F3) F2 plus post-spermatic fraction. Each group was stored for 5 days at ∼16 °C, and the following parameters were evaluated: sperm metabolism of pure and diluted semen (day 1), sperm quality parameters (days 1, 3, 5), thermal-resistance test (TRT) and incubation with uterine fluid (UF) (day 5). Sperm metabolic rates between accumulative ejaculate fractions from pure and diluted semen did not show differences. Also, sperm quality parameters were not affected by the ejaculate fraction during storage. However, sperm subjected to TRT showed similar results except for progressive motility, which was better in F2 and F3 than F1. When sperm were incubated with UF, the quality decreased in each group, but sperm from F2 and F3 were less affected than those from F1. In conclusion, the post-spermatic fraction can be included in seminal doses for their use in AI-centers, with functionality of sperm of different SP origins not being impaired throughout the storage, and responding better to thermal and UF stress. However, further research in AI-centers is necessary to test the sperm behaviour under presented conditions.
Honokiol affects the composition of gut microbiota and the metabolism of lipid and bile acid in methionine-choline deficiency diet-induced NASH mice
Authors: Zhai Ting , Wang Junjun , Chen Yong 
Published: September 2023

AbstractHonokiol (HNK), one of the main active components of Magnolia officinalis, has a positive effect on non-alcoholic steatohepatitis (NASH). However, the effects of HNK on the composition of serum lipids and bile acids (BAs) and gut microbiota (GM) of NASH mice are still unknown.C57BL/6 mice were fed with methionine-choline deficiency (MCD) diet and gavaged with HNK (20 mg/kg/d) for 8 weeks, then the serum lipids and BAs were detected by LC–MS, the composition of ileum microflora and the mRNA expression of hepatic BAs homeostasis related genes were analyzed by 16S rDNA sequencing and RT-qPCR, respectively. HNK treatment decreased the degree of hepatic lipid drops, inflammatory cell infiltration and fibrosis. Meantime, the serum levels of 34 lipids and 4 BAs in MCD mice were significantly altered by HNK treatment, as well as the increased abundance of Ruminococcaceae, Caulobacteraceae and Brevundimonas, and the decreased abundance of Firmicutes and Dubosiella. Besides, HNK treatment increased the hepatic mRNA expression of Oatp1b2 in MCD mice. The ameliorating effect of HNK on NASH may be partly related to its correction on the disorders of GM, serum lipids and BAs of MCD mice.
The efficacy and safety of anamorelin for patients with cancer-related anorexia/cachexia syndrome: a systematic review and meta-analysis
Authors: Taniguchi Jumpei , Mikura Sunao , da Silva Lopes Katharina 
Published: September 2023

AbstractCancer-related anorexia/cachexia syndrome (CACS) is characterized by anorexia and loss of body weight. Evidence is insufficient to strongly endorse any pharmacologic agent for the treatment of CACS. In this systematic review, we assessed the efficacy of oral anamorelin treatment for patients with CACS. On July 6, 2022, we systematically searched the following databases for randomized controlled trials (RCTs) of adults with CACS comparing oral anamorelin versus placebo: CENTRAL, PubMed, EMBASE, and ICHUSHI. The primary outcomes were total body weight (TBW), patient-reported quality of life (QOL), and adverse events (AEs). Secondary outcomes included lean body mass (LBM), overall survival (OS), non-dominant hand grip strength (HGS), and appetite. We included seven RCTs with a total of 1944 CACS patients. Anamorelin significantly increased TBW (mean difference (MD) 1.73, 95% confidence interval (CI) 1.34–2.13, p < 0.00001), LBM (MD 1.06, 95% CI 0.30–1.81, p = 0.006), and QOL (standardized mean difference (SMD) 0.16, 95% CI 0.04–0.27, p = 0.006) compared with placebo without a significant difference in all AEs, severe AEs, OS, HGS or appetite. Anamorelin may be an effective treatment for CACS patients; however, further studies are needed to confirm the efficacy and safety of this drug.
Thermal ages of the Huatung Basin determined from seismic waveform modeling: insights into Southeast Asia’s evolution
Authors: Ko Justin Yen-Ting , Kuo Ban-Yuan , Lin Shu-Chuan , Hung Yu-Sheng 
Published: September 2023

AbstractThe Huatung Basin (HB), situated on the leading part of the Philippine Sea Plate, is directly involved in oblique subduction and mountain building in the Taiwan region. However, previous studies have reported a wide range of ages for the HB, from 30 to 130 Ma, making it difficult to properly constrain regional tectonics. We analyzed teleseismic waveforms recorded on Taiwan that traveled through the slab associated with the HB. By waveform matching, we have constrained the slab dimensions to approximately 400 km in length and 150 km in width, accompanied by an enhanced P-wave velocity of 6% within the slab core and an apparent dip angle of 55°. We used age-dependent subduction zone thermal models to estimate the thermal ages or the ages since the last thermal event of the HB. The best-fit thermal model indicates thermal ages ranging from 20 to 50 Ma, which is consistent with a suite of geophysical observations and the age inferred from geomagnetic anomaly data. However, our results differ considerably from the ages obtained through radiometric dating of rocks dredged from the seafloor. The discrepancy in age may be attributed to either thermal rejuvenation of the plate or dating of allochthonous samples dredged from the border of the basin.
Exposure to the COVID-19 news on social media and consequent psychological distress and potential behavioral change
Authors: Montazeri Ali , Mohammadi Samira , M.Hesari Parisa , Yarmohammadi Hossein , Bahabadi Mehdi Rafiei , Naghizadeh Moghari Fatemeh , Maftoon Farzaneh , Tavousi Mahmoud , Riazi Hedyeh 
Published: September 2023

AbstractExposure to coronavirus disease 2019 (COVID-19) news pandemic is inevitable. This study aimed to explore the association between exposure to COVID-19 news on social media and feeling of anxiety, fear, and potential opportunities for behavioral change among Iranians. A telephone-based survey was carried out in 2020. Adults aged 18 years and above were randomly selected. A self-designed questionnaire was administered to collect information on demographic variables and questions to address exposure to news and psychological and behavioral responses regarding COVID-19. A multivariate logistic regression analysis was performed to assess the relationship between anxiety, fear, behavioral responses, and independent variables, including exposure to news. In all, 1563 adults participated in the study. The mean age of respondents was 39.17 ± 13.5 years. Almost 55% of participants reported moderate to high-level anxiety, while fear of being affected by COVID-19 was reported 54.1%. Overall 88% reported that they had changed their behaviors to some extent. Exposure to the COVID-19 news on social media was the most influencing variable on anxiety (OR 2.21, 95% CI 1.62–3.04; P < 0.0001), fear (OR 1.95, 95% CI 1.49–2.56; P < 0.0001), and change in health behaviors (OR 2.02, 95% CI 1.28–3.19; P = 0.003) in the regression model. The fear of being infected by the COVID19 was associated with the female gender and some socioeconomic characteristics. Although exposure to the COVID-19 news on social media seemed to be associated with excess anxiety and fear, it also, to some extent, had positively changed people’s health behaviors towards preventive measures.
Effects of the energy balance transition on bone mass and strength
Authors: Wallace Ian J. , Toya Christopher , Peña Muñoz Mario Antonio , Meyer Jana Valesca , Busby Taylor , Reynolds Adam Z. , Martinez Jordan , Thompson Travis Torres , Miller-Moore Marcus , Harris Alexandra R. , Rios Roberto , Martinez Alexis , Jashashvili Tea , Ruff Christopher B. 
Published: September 2023

AbstractChronic positive energy balance has surged among societies worldwide due to increasing dietary energy intake and decreasing physical activity, a phenomenon called the energy balance transition. Here, we investigate the effects of this transition on bone mass and strength. We focus on the Indigenous peoples of New Mexico in the United States, a rare case of a group for which data can be compared between individuals living before and after the start of the transition. We show that since the transition began, bone strength in the leg has markedly decreased, even though bone mass has apparently increased. Decreased bone strength, coupled with a high prevalence of obesity, has resulted in many people today having weaker bones that must sustain excessively heavy loads, potentially heightening their risk of a bone fracture. These findings may provide insight into more widespread upward trends in bone fragility and fracture risk among societies undergoing the energy balance transition.
Influence of gelatin type on physicochemical properties of electrospun nanofibers
Authors: de Farias Bruna Silva , Rizzi Francisca Zuchoski , Ribeiro Eduardo Silveira , Diaz Patrícia Silva , Sant’Anna Cadaval Junior Tito Roberto , Dotto Guilherme Luiz , Khan Mohammad Rizwan , Manoharadas Salim , de Almeida Pinto Luiz Antonio , dos Reis Glaydson Simões 
Published: September 2023

AbstractThis study explores the fabrication of nanofibers using different types of gelatins, including bovine, porcine, and fish gelatins. The gelatins exhibited distinct molecular weights and apparent viscosity values, leading to different entanglement behavior and nanofiber production. The electrospinning technique produced nanofibers with diameters from 47 to 274 nm. The electrospinning process induced conformational changes, reducing the overall crystallinity of the gelatin samples. However, porcine gelatin nanofibers exhibited enhanced molecular ordering. These findings highlight the potential of different gelatin types to produce nanofibers with distinct physicochemical properties. Overall, this study sheds light on the relationship between gelatin properties, electrospinning process conditions, and the resulting nanofiber characteristics, providing insights for tailored applications in various fields.
Comparative performance evaluation of QIAreach QuantiFERON-TB and tuberculin skin test for diagnosis of tuberculosis infection in Viet Nam
Authors: Vo Luan Nguyen Quang , Tran Thi Thu Phuong , Pham Hai Quang , Nguyen Han Thi , Doan Ha Thu , Truong Huyen Thanh , Nguyen Hoa Binh , Nguyen Hung Van , Pham Hai Thanh , Dong Thuy Thi Thu , Codlin Andrew , Forse Rachel , Mac Tuan Huy , Nguyen Nhung Viet 
Published: September 2023

AbstractCurrent WHO-recommended diagnostic tools for tuberculosis infection (TBI) have well-known limitations and viable alternatives are urgently needed. We compared the diagnostic performance and accuracy of the novel QIAreach QuantiFERON-TB assay (QIAreach; index) to the QuantiFERON-TB Gold Plus assay (QFT-Plus; reference). The sample included 261 adults (≥ 18 years) recruited at community-based TB case finding events. Of these, 226 underwent Tuberculin Skin Tests and 200 returned for interpretation (TST; comparator). QIAreach processing and TST reading were completed at lower-level healthcare facilities. We conducted matched-pair comparisons for QIAreach and TST with QFT-Plus, calculated sensitivity, specificity and area under a receiver-operating characteristic curve (AUC), and analyzed concordant-/discordant-pair interferon-gamma (IFN-γ) levels. QIAreach sensitivity and specificity were 98.5% and 72.3%, respectively, for an AUC of 0.85. TST sensitivity (53.2%) at a 5 mm induration threshold was significantly below QIAreach, while specificity (82.4%) was statistically equivalent. The corrected mean IFN-γ level of 0.08 IU/ml and corresponding empirical threshold (0.05) of false-positive QIAreach results were significantly lower than the manufacturer-recommended QFT-Plus threshold (≥ 0.35 IU/ml). Despite QIAreach’s higher sensitivity at equivalent specificity to TST, the high number of false positive results and low specificity limit its utility and highlight the continued need to expand the diagnostic toolkit for TBI.
Neural and behavioral signatures of the multidimensionality of manipulable object processing
Authors: Almeida Jorge , Fracasso Alessio , Kristensen Stephanie , Valério Daniela , Bergström Fredrik , Chakravarthi Ramakrishna , Tal Zohar , Walbrin Jonathan 
Published: September 2023

AbstractUnderstanding how we recognize objects requires unravelling the variables that govern the way we think about objects and the neural organization of object representations. A tenable hypothesis is that the organization of object knowledge follows key object-related dimensions. Here, we explored, behaviorally and neurally, the multidimensionality of object processing. We focused on within-domain object information as a proxy for the decisions we typically engage in our daily lives – e.g., identifying a hammer in the context of other tools. We extracted object-related dimensions from subjective human judgments on a set of manipulable objects. We show that the extracted dimensions are cognitively interpretable and relevant – i.e., participants are able to consistently label them, and these dimensions can guide object categorization; and are important for the neural organization of knowledge – i.e., they predict neural signals elicited by manipulable objects. This shows that multidimensionality is a hallmark of the organization of manipulable object knowledge.
Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury
Authors: Pei Jun , Tian Xiaomao , Yu Chengjun , Luo Jin , Hong Yifan , Zhang Jie , Wen Sheng , Hua Yi , Wei Guanghui 
Published: September 2023

Abstract
Renal ischemia–reperfusion injuries (IRIs) are one of the leading causes of acute kidney injuries (AKIs). Selenium, as an essential trace element, is able to antioxidant stress and reduces inflammatory responses. The regulation mechanism of selenomethionine, one of the major forms of selenium intake by humans, is not yet clear in renal IRIs. Therefore, we aimed to explore the key targets and related mechanisms of selenomethionine regulation in renal IRIs and provide new ideas for the treatment of selenomethionine with renal IRIs. We used transcriptome sequencing data from public databases as well as animal experiments to explore the key target genes and related mechanisms regulated by selenomethionine in renal IRI. We found that selenomethionine can effectively alleviate renal IRI by a mechanism that may be achieved by inhibiting the MAPK signaling pathway. Meanwhile, we also found that the key target of selenomethionine regulation in renal IRI might be selenoprotein GPX3 based on the PPI protein interaction network and machine learning. Through a comprehensive analysis of bioinformatic techniques and animal experiments, we found that Gpx3 might serve as a key gene for the regulation of selenomethionine in renal IRIs. Selenomethionine may exert a protective effect against renal IRI by up-regulating GPX3, inhibiting the MAPK signaling pathway, increased production of antioxidants, decreasing inflammation levels, mitigation of apoptosis in renal tubular epithelial cells, this reduces renal histopathological damage and protects renal function. Providing a theoretical basis for the mechanism of selenomethionine actions in renal IRIs.
Patient-Reported Outcome Measures for Hearing Aid Benefit and Satisfaction: Content Validity and Readability
Authors: Oosthuizen Ilze , Kumar Lakshmi Magudilu Srishyla , Nisha Kavassery Venkateswaran , Swanepoel De Wet , Granberg Sarah , Karlsson Elin , Manchaiah Vinaya 
Published: September 2023

Purpose:
Numerous patient-reported outcome measures (PROMs) are available to measure hearing aid benefit and satisfaction. It is unclear to what extent currently available PROMs on hearing aid outcomes, often developed decades ago, meet current guidelines for good content validity and readability. This study evaluated the content validity and readability of PROMs that focus on perceived hearing aid benefit and/or satisfaction.

Method:
A literature review was conducted to identify eligible instruments. Content validity evaluation included mapping extracted questionnaire items to the World Health Organization's International Classification of Functioning, Disability and Health (ICF) framework. In addition, study design in content validity methodology was evaluated using the COnsensus-based Standards for the selection of health Measurement INstruments study design checklist for PROM instruments. Readability was estimated using the Simple Measure of Gobbledygook measure.

Results:
Thirteen questionnaires were identified and evaluated. Item content focused primarily on the components of environmental factors as well as activity limitations and participation restrictions with less emphasis on body functions and personal factors. The content validity methodology analysis revealed an underuse or lack of reporting of a qualitative methodology in assessing patient and professional perspectives. All the included questionnaires exceeded the recommended sixth-grade reading level.

Conclusions:
The categories covered by hearing aid PROMs vary considerably, with no single instrument comprehensively covering all the key ICF components. Future development of hearing aid outcome measures should consider a mixed methodology approach for improved content validity and ensure an appropriate reading level.
Perceptions of Freedom of Speech on College Campuses: A Survey of Communication Sciences and Disorders Faculty
Authors: Roitsch Jane , Raymer Anastasia M. 
Published: September 2023

Purpose:
The purpose of this study was to survey communication sciences and disorders (CSD) faculty in the United States to determine their perspectives and knowledge about freedom of speech on college campuses.

Method:
An online, anonymous survey was presented to interested CSD faculty, recruited from the American Speech-Language-Hearing Association Higher Education Special Interest Group 10, who answered Likert-style questions regarding demographics, perceptions, and university experiences pertaining to free speech.

Results:
The 91 respondents represented mostly White female faculty and administrators from across the United States. The vast majority valued free speech, felt their free speech was supported at their university, considered that free speech must be balanced with respect for others, and valued ideological diversity. Respondents reported differing opinions regarding how supported they felt about their freedom of speech in all cases. More hostility was reported for conservative over liberal beliefs.

Conclusions:
This study's findings suggest that although perceptions regarding free speech vary for faculty and administrators, most respondents felt their free speech was supported by their university. However, as some individuals do not feel supported, consideration of ways to welcome open discussions with differing opinions within academic programs is warranted.
Clinical Use of a New Membrane Oxygenator
Authors: Dearing James P. , Crawford Fred A. , Kratz John M. , Stroud Martha 
Published: September 2023

A new oxygenator, developed by Shiley Laboratories, uses microporous polypropylene membrane material in a parallel plate design. The device has an integral heat exchanger and built-in temperature ports.
The M-2000 oxygenator was used for routine cardiopulmonary bypass ( CPB) during open heart surgery on sixteen consenting adult patients. Mean age of the group was 56 years and the mean body surface area was 1.77m2. One patient had an atrial septal defect repaired, nine had coronary bypass, five had valve replacement and one, a valve replacement with coronary bypass. The average CPB time was 105 minutes.
The circuit was primed with 2000 ml of balanced electrolyte solution and 500 ml of 6% hydroxyethyl starch in 0.9% saline to which 1500 units of heparin had been added.
Average normothermic blood gas values were; PaO2=242 mm Hg, PaCO2=32.5 mmHg. During hypothermia the temperature corrected mean values were; PaO2=155 mm Hg and PaCO2=31 mm Hg. Hematological changes observed were hematocrit and hemoglobin concentrations decreased 33% due to dilution. Platelet counts decreased 46%. Plasma hemoglobin values increase a by 19.6 mg/dl.
The M-2000 presented no problems to the investigators during this study. It exchanged gases in a satisfactory manner and is gentle in its blood handling properties.
In Vitro Effects of Priming Agents on Blood Sedimentation Rate and Viscosity
Authors: Coston Howard P. , Dearing James P. 
Published: September 2023

Blood from seven male patients undergoing coronary bypass surgery was mixed with four priming agents (hydroxyethyl starch (HES), low molecular weight dextran (LMWD), lactated Ringer’s solution (LRS), and 5 percent normal serum albumin (ALB), at concentrations of I percent, 10 percent, 20 percent, and 30 percent. Each sample was then assayed for erythrocyte sedimentation rate (ESR), and blood and plasma viscosities.
Results show a positive correlation between increasing HES concentration and ESR, blood viscosity, and plasma viscosity. A positive correlation also exists between increasing LMWD concentration and blood and plasma viscosities. However, a negative correlation was found between LMWD concentration and ESR.
Results indicate a significant red cell aggregating property for HES, and a significant inhibition of red cell aggregation by LMWD.