bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomised, double‐blinded trial to assess the effect of oclacitinib and prednisolone on intradermal allergen and prick tests in dogs with atopic dermatitis
Authors: Baretta Letícia Talita , do Espírito Santo Cunha Victor , Figueiredo Cristiane Deon , Gerardi Daniel Guimarães 
Published: September 2023

AbstractBackgroundIntradermal (IDT) and prick (PT) tests are used to select allergens for allergen‐specific immunotherapy in dogs with atopic dermatitis (cAD). However, the use of antipruritic drugs before performing these tests may influence the results.ObjectiveTo evaluate the influence of the drugs oclacitinib and prednisolone on the immediate‐phase reactions of IDT and PT.AnimalsThirty client‐owned dogs with cAD with positive reactions to at least one allergen extract on IDT or PT.Materials and MethodsDogs were randomly assigned to receive oclacitinib 0.4–0.58 mg/kg per os, every 12 h (n = 14), or prednisolone 0.37–0.65 mg/kg p.o., every 12 h (n = 16) for 14 days. IDT and PT were performed on Day (D)0 before treatment and on D14.ResultsAt D14 there was no significant reduction in the means of the orthogonal diameters of the positive immediate‐phase reactions of the IDT (p = 0.064) in the oclacitinib group; however, in the PT, the diameter of the positive reactions reduced significantly (p = 0.048). In both tests, there was no significant reduction in the total number of positive reactions (IDT, p > 0.999; PT, p = 0.735). In the prednisolone group, the means of the orthogonal diameters of positive immediate‐phase reactions were significantly reduced in both tests (IDT, p = 0.001; PT, p ≤ 0.001) and there also was a reduction in the total number of positive reactions (IDT, p = 0.022; PT, p = 0.001).Conclusions and Clinical RelevanceThe use of oclacitinib 0.4–0.58 mg/kg twice daily for 14 days does not interfere with IDT results in dogs with cAD. However, oclacitinib may reduce PT reactivity. The use of prednisolone 0.37–0.65 mg/kg twice daily results in a reduction in both IDT and PT results.
Reviewer Acknowledgements for Journal of Education and Training Studies, Vol. 11, No. 4
Authors: Smith Robert 
Published: September 2023

Journal of Education and Training Studies (JETS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether JETS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 11, Number 4 Alphonce John Amuli, ADEM, TanzaniaAshraf Elsafty, Eslsca University, EgyptChris Mutseekwa, Bindura University of Science Education, ZimbabweIntakhab Khan, King Abdulaziz University, Saudi ArabiaJacinthe Rihan, Ain Shams University, EgyptJane Liang, California Department of Education, USAJingwu Yao, Business School of Yulin Normal University, ChinaJohn Cowan, Edinburgh Napier University, UKJohn Mark Asio, Gordon College, PhilippinesMustafa Çakır, Marmara University, TurkeyNiveen M. Zayed, MENA College of Management, JordanRichard H. Martin, Mercer University, USARichard Penny, University of Washington Bothell, USASamson Chama, Alabama A & M University, USASarah Nabih Nasif, October University, EgyptStamatis Papadakis, University of Crete, GreeceWong Ken Keong, Inspectorate of School Sabah, Malaysia Robert SmithEditorial AssistantOn behalf of,The Editorial Board of Journal of Education and Training StudiesRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAE-mail 1: jets@redfame.comE-mail 2: jets@redfame.orgURL: http://jets.redfame.com
Correspondences and stable homotopy theory
Authors: Garkusha Grigory 
Published: September 2023

AbstractA general method of producing correspondences and spectral categories out of symmetric ring objects in general categories is given. As an application, stable homotopy theory of spectra is recovered from modules over a commutative symmetric ring spectrum defined in terms of framed correspondences over an algebraically closed field. Another application recovers stable motivic homotopy theory from spectral modules over associated spectral categories.
Attenuating intrathoracic pressure swings decreases cardiac output at different intensities of exercise
Authors: Angus Sarah A. , Taylor Joshua L. , Mann Leah M. , Williams Alexandra M. , Stöhr Eric J. , Au Jason S. , Sheel Andrew William , Dominelli Paolo B. 
Published: September 2023

AbstractIntrathoracic pressure (ITP) swings that permit spontaneous ventilation have physiological implications for the heart. We sought to determine the effect of respiration on cardiac output () during semi‐supine cycle exercise using a proportional assist ventilator to minimize ITP changes and lower the work of breathing (Wb). Twenty‐four participants (12 females) completed three exercise trials at 30%, 60% and 80% peak power (Wmax) with unloaded (using a proportional assist ventilator, PAV) and spontaneous breathing. Intrathoracic and intraabdominal pressures were measured with balloon catheters placed in the oesophagus and stomach. Left ventricular (LV) volumes and were determined via echocardiography. Heart rate (HR) was measured with electrocardiogram and a customized metabolic cart measured oxygen uptake (). Oesophageal pressure swings decreased from spontaneous to PAV breathing by −2.8 ± 3.1, −4.9 ± 5.7 and −8.1 ± 7.7 cmH2O at 30%, 60% and 80% Wmax, respectively (P = 0.01). However, the decreases in Wb were similar across exercise intensities (27 ± 42 vs. 35 ± 24 vs. 41 ± 22%, respectively, P = 0.156). During PAV breathing compared to spontaneous breathing, decreased by −1.0 ± 1.3 vs. −1.4 ± 1.4 vs. −1.5 ± 1.9 l min−1 (all P < 0.05) and stroke volume decreased during PAV breathing by −11 ± 12 vs. −9 ± 10 vs. −7 ± 11 ml from spontaneous breathing at 30%, 60% and 80% Wmax, respectively (all P < 0.05). HR was lower during PAV breathing by −5 ± 4 beats min−1 at 80% Wmax (P < 0.0001). Oxygen uptake decreased by 100 ml min−1 during PAV breathing compared to spontaneous breathing at 80% Wmax (P < 0.0001). Overall, attenuating ITPs mitigated LV preload and ejection, thereby suggesting that the ITPs associated with spontaneous respiration impact cardiac function during exercise.
imageKey points
Pulmonary ventilation is accomplished by alterations in intrathoracic pressure (ITP), which have physiological implications on the heart and dynamically influence the loading parameters of the heart.
Proportional assist ventilation was used to attenuate ITP changes and decrease the work of breathing during exercise to examine its effects on left ventricular (LV) function.
Proportional assist ventilation with progressive exercise intensities (30%, 60% and 80% Wmax) led to reductions in cardiac output at all intensities, primarily through reductions in stroke volume.
Decreases in LV end‐diastolic volume (30% and 60% Wmax) and increases in LV end‐systolic volume (80% Wmax) were responsible for the reduction in stroke volume.
The relationship between cardiac output and oxygen uptake is disrupted during respiratory muscle unloading.
Best Practices for Electricity Generators and Energy Storage Optimal Dispatch Problems
Authors: Vasylyev Andriy , Vannoni Alberto , Sorce Alessandro 
Published: September 2023

Abstract
The growing share of renewable energy sources in the energy mix and the liberalization of electricity markets has drastically affected the operation of electricity generators. Especially, in the last decade, fossil fuel-based generators have shifted their role from providing continuous base load to covering the peak demand and providing backup capacity to stabilize the grid. At the same time, a large amount of storage capacity is foreseen to be integrated into electricity grids in the coming years to shave demand peaks, mitigate price volatility, and provide services to the grid. In such a situation, in order to properly manage these crucial technologies, and thus guarantee the economic viability of the operation, it is essential to properly optimize the dispatch and define the best scheduling. This paper considers a gas turbine combined cycle and battery energy storage to study the problem of dispatch optimization of both generators and storage technologies. Different optimization algorithms have been considered and mixed integer linear programming is selected for its ability to identify the global optimum and the reduced optimization time. The impact of optimization windows (i.e., the forecast horizon of electricity prices) is also investigated. It is highlighted that an increase in forecasting ability, at least up to 36 h, guarantees more effective scheduling; on the other hand, it may require a significantly longer time. Subsequently, different approaches to account for the operation and maintenance costs at the optimization stage are assessed, and, finally, a sensitivity analysis is carried out with respect to market parameters (price average and variability) and technology features (conversion efficiency, cycle cost, etc.).
Linear System Identification and Control of a Small-Scale Hip Exoskeleton Using Shape Memory Alloy Springs in Hexagonal Architecture
Authors: Ali Hussein F. M. , Kim Youngshik , Mohamed Shuaiby 
Published: September 2023

Abstract
In this paper, we develop a small-scale hip exoskeleton by utilizing double acting artificial muscle comprised of shape memory alloy (SMA) springs arranged in hexagonal architecture. This exoskeleton enables both hip extension and flexion motions by selectively heating the corresponding group of SMA springs. The prototype has an operational range spanning from −20° to 200°. Thermo-mechanical characterization experiments were conducted to evaluate the performance of the SMA springs, while an inertial measurement unit (IMU) provided feedback on the hip angles. Temperature measurements of each SMA spring group were obtained using thermocouples, facilitating control actions. Furthermore, system identification and PID tuning techniques were employed to enhance the proportional-integrator-derivative (PID) controller, enabling trajectory tracking of the hip angle and temperature. Experimental results demonstrate the successful tracking of desired trajectories by the hip joint prototype.
Ultrasound diagnosis of the small intestinal adenomyoma in children
Authors: Yan Yuxi , Liu Qinghua , Zhang Huafang , Chen Yegang , Wang Qiannan 
Published: September 2023

Aim: Adenomyoma is an exceptionally rare hamartoma in the small intestine. Few data have been reported on the features of this rare disease. The aim of this study was to describe the ultrasound (US) characteristics of small intestinal adenomyomas. Material and methods: This retrospective study analyzed the clinical features and US data of 15 pediatric patients diagnosed as small intestinal adenomyomas in the age range between 1 day to 12 years in our hospital during 2014–2021.Results: The clinical manifestations of all the small intestinal adenomyomas were abdominal pain, vomiting or/and hemafecia. The small intestinal adenomyoma usually acted as the lead point of secondary intussusception. They were identified in the ileum (n=11), jejunum (n=2), and Meckel’s diverticulum (n=2). The diagnostic accuracy (the concordance rate between US diagnosis and pathological diagnosis) of small intestinal adenomyoma was 73.3%. The small intestinal adenomyoma had approximately 1.0–3.0 cm, were typically located in the submucosal region, had the basal part wide and without a pedicle, and its boundaries were clear. The mass protruded into the intestinal cavity, and showed oval hypoechoic polycystic echo nodules, containing multiple small quasi-circular or irregular cysts of different sizes surrounded by solid hypoechoic mosaic areas. The color Doppler US showed in the solid hypoechoic areas of the mass abundant or sparse blood flow signals.Conclusions The US findings of small intestinal adenomyomas in children are characteristic, and US is valuable in the identification of intestinal adenomyomas in children.
HCMV UL8 interaction with β-catenin and DVL2 regulates viral reactivation in CD34
+
hematopoietic progenitor cells
Authors: Dirck Aaron , Diggins Nicole L. , Crawford Lindsey B. , Perez Wilma D. , Parkins Christopher J. , Struthers Hillary H. , Turner Rebekah , Pham Andrew H. , Mitchell Jennifer , Papen Courtney R. , Malouli Daniel , Hancock Meaghan H. , Caposio Patrizia 
Published: September 2023

ABSTRACT

Human cytomegalovirus (HCMV) is a species-specific virus that establishes a persistent/latent infection in CD34
+
hematopoietic progenitor cells (HPCs). The ability of HCMV to reactivate from latency is exquisitely linked to changes in cell signaling, which result in HPC differentiation. The Wnt/β-catenin pathway is tightly linked to CD34
+
HPC homeostasis and differentiation. The majority of the viral and cellular factors involved in the maintenance of HCMV latency and reactivation are still unknown. Our group previously discovered a viral hematopoietic cytokine (pUL7) that promotes cellular differentiation and viral reactivation. Here, we show that the UL7-related RL11 family member UL8 is also required for efficient viral reactivation in CD34
+
HPCs by interacting with components of the (Wnt)/β-catenin pathway. Pull-down experiments demonstrate that UL8 and β-catenin interact with Dishevelled-2 (DVL2) through their PDZ-binding domains, and this interaction promotes β-catenin stabilization and transcriptional activation. Disrupting the interaction among UL8, β-catenin, and DVL2 blocks HCMV reactivation
in vitro
and
in vivo
, similar to deletion of UL8. This is the first observation that Wnt signaling components are essential for HCMV reactivation, unlike α- and γ-herpesvirus that require an active Wnt pathway to maintain latency. Detailed understanding of how the Wnt network is manipulated by herpesviruses will improve our ability to develop targeted therapeutics.

IMPORTANCE

CD34
+
hematopoietic progenitor cells (HPCs) are an important cellular reservoir for latent human cytomegalovirus (HCMV). Several HCMV genes are expressed during latency that are involved with the maintenance of the viral genome in CD34
+
HPC. However, little is known about the process of viral reactivation in these cells. Here, we describe a viral protein, pUL8, and its interaction and stabilization with members of the Wnt/β-catenin pathway as an important component of viral reactivation. We further define that pUL8 and β-catenin interact with DVL2 via a PDZ-binding domain, and loss of UL8 interaction with β-catenin-DVL2 restricts viral reactivation. Our findings will be instrumental in understanding the molecular processes involved in HCMV reactivation in order to design new antiviral therapeutics.
Whole-genome sequence of
Haemophilus parainfluenzae
EL1 isolated from healthy supragingival plaque
Authors: de Palma Thais H. , Loomis Emily , Perera Dasith , Ramsey Matthew 
Published: September 2023

ABSTRACT

Haemophilus parainfluenzae
is a Gram-negative bacterium that colonizes the mouth and the upper respiratory tract. Here, we report the genome sequence of
H. parainfluenzae
strain EL1 isolated from healthy supragingival plaque. This strain is used as a representative commensal of the oral microbiota.
Draft genome sequences of two
Proteus mirabilis
isolates recovered from a municipal wastewater treatment plant in Ontario, Canada
Authors: Botschner William , Davidson Hailey , Lawal Opeyemi U. , Parreira Valeria R. , Goodridge Lawrence 
Published: September 2023

ABSTRACT

Proteus mirabilis
is a Gram-negative bacterium that is frequently implicated in urinary tract infections in humans and companion animals and has also been associated with foodborne infections in several countries. Here, we report the draft genome sequences of two
P. mirabilis
isolates recovered from municipal wastewater.
Complete genome sequences of butyrate producing
Anaerostipes hadrus
strains BA1 and GIF7 isolated from the terminal ileum of a healthy lean male
Authors: Low Adrian , Sheludchenko Maxim , Cheng Huay Ee , Koh Xiu Qi , Lee Jonathan Wei Jie 
Published: September 2023

ABSTRACT

Anaerostipes hadrus
strains BA1 and GIF7 were isolated from a healthy man. The complete genomes’ sizes are 2,946,270 bp (BA1) and 2,907,308 bp (GIF7), with high average nucleotide identity (ANIb = 100%) and alignments ≥96.86% between strains. Conversely, both strains share 97.47% (ANIb) identity and ≤77.36% alignments to
A. hadrus
ATCC 29173
T
.
Complete genome sequences of G
ordonia rubripertincta
phages OtterstedtS21 and Patos
Authors: Meng Bowen , Bleau Alexander , Bombaywala Riddhi R. , DeGraw Audrey S. , Deol Manjot S. , Dollard Kendall E. , Gentile Nicolas , Jebaraj Julianna , Kayayan Gregory N. , Miranda Briana C. , Momoh Ayobamidele E. , Morales Elias , Nunes Amalia C. , Oropallo Antonia M. , Otterstedt Sophia C. , Pridell Anna T. , Roberts Jenna I. , Ruiz Gabriel A. , Sangasani Dhatri , Smith Renee D. , Tarar Mahad , Singh Vir , Jayachandran Pradeepa 
Published: September 2023

ABSTRACT

We report the genomes of two viruses with siphovirus morphology, OtterstedtS21 and Patos, from Albany, New York, using
Gordonia rubripertincta
. The genomes of OtterstedtS21 and Patos are ~68 kbp long with 58% GC content. Both phages group with cluster DV based on gene content similarity to phages in the Actinobacteriophage database.
Geographical and sociodemographic differences in statin dispensation after acute myocardial infarction in Sweden: a register-based prospective cohort study applying analysis of individual heterogeneity and discriminatory accuracy (AIHDA) for basic comparisons of healthcare quality
Authors: Merlo Juan , Öberg Johan , Khalaf Kani , Perez-Vicente Raquel , Leckie George 
Published: September 2023

BackgroundIn Sweden, as in many other countries, official monitoring of healthcare quality is mostly focused on geographical disparities in relation to a desirable benchmark. However, current evaluations could be improved by considering: (1) The intersection of other relevant axes of inequity like age, sex, income and migration status; and (2) The existence of individual heterogeneity around averages. Therefore, using an established quality indicator (ie, dispensation of statins after acute myocardial infarction, AMI), we valuate both geographical and sociodemographic inequalities and illustrate how the analysis of individual heterogeneity and discriminatory accuracy (AIHDA) enhances such evaluations.Population and methodsWe applied AIHDA and calculated the area under the receiver operating characteristics curve (AUC) of regional and sociodemographic differences in the statin dispensations of 35 044 patients from 21 Swedish regions and 24 sociodemographic strata who were discharged from the hospital with an AMI diagnosis between January 2011 and December 2013. Following the Swedish National Board of Health and Welfare, we used a benchmark value of 90%.ResultsDispensation of stains after AMI in Sweden did not reach the desired target of 90%. Regional differences were absent/very small (AUC=0.537) while sociodemographic differences were small (AUC=0.618). Women, especially those with immigrant background and older than 65 years, have the lowest proportions of statin dispensations after AMI.ConclusionsAs the AUC statistics are small, interventions trying to achieve the benchmark value should be universal. However, special emphasis should nevertheless be directed towards women, especially older women with immigrant backgrounds.
Factors associated with COVID-19 vaccine uptake in adolescents: a national cross-sectional study, August 2021–January 2022, England
Authors: Aiano Felicity , Ireland Georgina , Powell Annabel , Campbell Colin N J , Judd Alison , Davies Byron , Saib Anisah , Mangtani Punam , Nguipdop-Djomo Patrick ,   SIS Study Group, Ladhani Shamez N 
Published: September 2023

ObjectivesTo assess socioeconomic and geographical factors associated with COVID-19 vaccine uptake in pupils attending state-funded secondary schools in England.DesignCross-sectional observational study.SettingState-funded schools in England.ParticipantsPupils aged 12–17 years attending state-funded schools in England for the academic year 2021/2022.Outcome measuresDemographic, socioeconomic and geographical factors associated with vaccination uptake. We linked individual-level data from the English Schools Census to the National Immunisation Management System to obtain COVID-19 vaccination status of 3.2 million adolescents. We used multivariable logistic regression to assess demographic, socioeconomic and geographical factors associated with vaccination.ResultsBy 9 January 2022, 56.8% of adolescents aged 12–17 years old had received at least one dose, with uptake increasing from 48.7% in those aged 12 years old to 77.2% in those aged 17 years old. Among adolescents aged 12–15 years old, there were large variations in vaccine uptake by region and ethnic group. Pupils who spoke English as an additional language (38.2% vs 55.5%), with special educational needs (48.1% vs 53.5%), eligible for free school meals (35.9% vs 58.9%) and lived in more deprived areas (36.1% in most deprived vs 70.3% in least deprived) had lower vaccine uptake. Socioeconomic variables had greater impact on the odds of being vaccinated than geographical variables. School-level analysis found wide variation in vaccine uptake between schools even within the same region. Schools with higher proportions of pupils eligible for free school meals had lower vaccine uptake.ConclusionsWe found large differences in vaccine uptake by geographical region and ethnicity. Socioeconomic variables had a greater impact on the odds of being vaccinated than geographical variables. Further research is required to identify evidence-based interventions to improve vaccine uptake in adolescents.
Workplace violence against COVID-19 front-line healthcare workers versus non-front-line in Hangzhou, China: a cross-sectional study
Authors: Jiang Dongdong , Wang Qian , Xiao Xiaohua , Zhang Jin , Xie Ying , Zhu Yunying , Li Sisi , Bao Lei , Song Haidong , Yang Qian 
Published: September 2023

ObjectivesWorkplace violence (WPV) against healthcare workers (HCWs) is a global issue. Our research aimed to elucidate the status and associated factors of WPV among front-line/non-front-line HCWs during the COVID-19 pandemic.DesignThis cross-sectional study was conducted among HCWs in Hangzhou City through multistage sampling from December 2020 to January 2021.ParticipantsThis study included 14 909 valid samples (N=3748 front-line HCWs and N=11 161 non-front-line HCWs).Primary and secondary outcome measuresWe assessed the WPV status by Chinese version of WPV questionnaire. Binary logistic regression model was established to examine the associated factors of front-line/non-front-line HCWs experiencing WPV.ResultsThe total WPV prevalence equalled 37.25% for front-line HCWs and 27.73% for non-front-line HCWs. Among front-line HCWs, females were less likely to experience WPV (OR 0.837, 95% CI 0.710 to 0.988), while individuals who were undergraduate (OR 1.251, 95% CI 1.061 to 1.541) and had higher professional title (intermediate: OR 1.475, 95% CI 1.227 to 1.772; advanced: OR 1.693, 95% CI 1.294 to 2.216) were more likely to suffer from WPV; for non-front-line HCWs, individuals who aged over 50 years old (OR 0.721, 95% CI 0.563 to 0.969), had worked between 10 and 19 years (OR 0.847, 95% CI 0.749 to 0.958) and worked in the non-graded hospital (OR 0.714, 95% CI 0.614 to 0.832) had less chance to experience WPV, while individuals who had higher educational level (undergraduate: OR 1.323, 95% CI 1.179 to 1.484; ≥graduate: OR 1.519, 95% CI 1.217 to 1.895), were nurse (OR 1.142, 95% CI 1.031 to 1.265), and had higher professional title (intermediate: OR 1.458, 95% CI 1.297 to 638; advanced: OR 1.928, 95% CI 1.607 to 2.313) were more inclined to suffer from WPV (p all<0.05).ConclusionsThis study indicates that the prevalence of WPV among front-line HCWs is significantly higher than among non-front-line HCWs. Policy-makers should prioritise COVID-19 front-line HCWs, especially those with high educational levels and professional titles.