bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peli1, regulated by m 6 A modification, suppresses atherosclerosis progression by inhibiting YB-1-mediated NLRP3 inflammasome activation
Authors: Liu Qiang , Yan Lu , Wu Tao , Wu Qinghua , Ke Ben , Shen Wen 
Published: July 2023

AbstractBackground The activation of NLRP3 inflammasome in macrophages is a risking factor accelerating atherosclerosis (AS) progression. Here, the function of Peli1 in regulating NLRP3 inflammasome activation during AS progression were investigated. MethodsApoE−/−mice were subjected to high fat diet to construct AS modelin vivo. HE, Oil red O and Sirius red staining were adopted to analyze histopathological changes and lipid accumulation. Raw264.7 cells stimulated by ox-LDL were used as AS cellular model. Pro-inflammatory cytokines secretion was assessed using ELISA. Total m6A level was examined by m6A dot blot assay, and Peli1 m6A level was assessed using MeRIP assay. The interactions between METTL3, YTHDC2, Peli1, YB-1 and NLRP3 were analyzed by ChIP, dual-luciferase reporter gene, CoIP, RIP and/or RNA pull down assays. Results YB-1 knockdown could inhibit AS progressionin vivo, and YB-1 silencing repressed ox-LDL-mediated lipid accumulation and inflammation in macrophages by inactivating NLRP3 inflammasome. E3 ubiquitination ligase Peli1 mediated ubiquitination degradation of YB-1 during AS progression. Moreover, it was found that YTHDC2 recognized METTL3-mediated Peli1 m6A modification and mediated Peli1 mRNA degradation. Rescue studies revealed that YB-1 upregulation abrogated Peli1 upregulation’s repression on AS progression bothin vitroandin vivo. Conclusion Peli1, regulated by m6A modification, inhibited YB-1-mediated NLRP3 inflammasome activation in macrophages by promoting YB-1 ubiquitination to suppress AS progression.
Elevated serum α-hydroxybutyrate dehydrogenase is an independent risk factor for survival outcomes in UTUC patients after radical nephroureterectomy
Authors: Ye Jianjun , Chen Zeyu , Wang Xingyuan , Zhang Chichen , Han Ping , Wei Qiang , Bao Yige 
Published: July 2023

Abstract
Background
To determine the prognostic value of α-hydroxybutyrate dehydrogenase (α-HBDH) on survival outcomes in upper tract urothelial carcinoma (UTUC) patients after radical nephroureterectomy (RNU).
Methods
Data from 544 UTUC patients who underwent RNU at West China Hospital from May 2003 to June 2019 were retrospectively acquired and analysed. Overall survival (OS), cancer-specific survival (CSS) and metastasis free survival (MFS) were the endpoints of interest. The cut-off value of α-HBDH was calculated by receiver operating characteristic. Kaplan-Meier curves were used to estimate patients’ survival and Cox proportional hazard model was used for risk assessment.
Results
Overall, 407 and 137 patients were divided into the α-HBDH-low group and α-HBDH -high group at the cutoff value of 161 U/L. Patients in the α-HBDH-high group showed significantly worse OS (p = 0.003), CSS (p = 0.025) and MFS (p = 0.031) than those in the α-HBDH-low group. However, serum α-HBDH level was not an independent predictor for OS, CSS or MFS in the multivariate Cox regression (all p > 0.05). The subsequent subgroup analysis about the pathological tumor stage suggested that higher serum α-HBDH value was significantly associated with better OS and CSS in localized UTUC patients (T ≤ 2) (HR 2.127, 95%CI 1.313–3.445; HR 1.846, 95%CI 1.030–3.308), but not in locally advanced UTUC patients (T > 2) (all p > 0.05).
Conclusion
The preoperative value of α-HBDH is an independent risk factor for survival outcomes in localized UTUC patients who underwent RNU.
Expansion of Thermoelectric Effect
Authors: Song Dongil 
Published: July 2023

Abstract
The thermoelectric effect of two metals was discovered by T. J. Seebeck, a German physicist. This research extends the thermoelectric effect of Seebeck's two metals. In this research, the thermoelectric effect of 16 materials, including soil, was tested. As a result of the test, electromotive force was generated when there was a temperature difference in all of them. Due to this electromotive force, current flows. This current creates a magnetic field (framing's left-hand rule). As no material has infinite electric resistance, an electromotive force is expected to be generated under a temperature difference in all materials. In conclusion, the thermoelectric effect generates an electromotive force. This electromotive force causes an electric current to flow, thereby generating a magnetic field. This magnetic field creates the Earth's magnetic field, Triboelectricity, Sunspots, Lightning, Earth's rotation, and the Kinetic Energy of Celestial Bodies. And it creates an ionosphere that reflects radio waves.
Adjunctive antihypertensive therapy of primary glaucoma with a fixed combination drug of 1% brinzolamide and 0.5% timolol: efficacy and safety
Authors: Petrov S. Yu. , Kalinina O. M. , Yakubova L. V. , Kosakyan S. M. , Vasilenkova L. V. , Filippova O. M. , Zhuravleva A. N. , Markelova O. I. 
Published: July 2023

Purpose: a comparative study of the efficacy and safety of the combination drug Brinzopt Plus and the original drug Azarga used as adjunctive therapy in patients with primary open-angle glaucoma (POAG) previously treated with latanoprost.Material and methods. 30 patients (42 eyes) with advanced and far advanced POAG were randomly divided into 2 groups of equal size. The patients of the main group (21 eyes) received Brinzopt Plus, those of the control group had the original drug Azarga, one instillation 2 times a day. The target points were intraocular pressure (IOP), visual acuity, perimetric indices (MD, PSD), mean retinal nerve fiber layer thickness, minimal neuroretinal rim width, retinal nerve fiber layer thickness in the macula, ganglion cell layer thickness in the macula, inner plexiform layer thickness, as well as the number of adverse events. The observation period was 12 weeks. IOP was measured at 4 and 12 weeks.Results. After 2 weeks, both groups showed a statistically significant decrease in IOP, which remained stable after 4 and 12 weeks. The average decrease in IOP in Brinzopt Plus recipients was 25% and revealed no statistically significant differences with the original drug at any control point. A positive dynamic of visual acuity, static perimetry and optical coherence tomography values, which showed no significant intergroup differences, was recorded. Among the adverse events, manifestations of mild local discomfort were recorded in 4 out of 15 patients of the main group and in 3 out of 15 patients of the control group. No serious or systemic adverse events were noted.Conclusion. Brinzopt Plus has an efficacy comparable to the original drug and a favorable safety profile.
Prevalence of myopia among teenager students of Orenburg city schools
Authors: Aprelev A. E. , Cherkasov S. V. , Serebryakova P. E. , Aprelev A. A. , Cherkasova P. S. 
Published: July 2023

Purpose: to study the prevalence and manifestation features of myopia in students of educational schools in the city of Orenburg.Material and methods. 710 schoolchildren of Orenburg schools, aged 11 to 18, were examined.Results. Myopia was found to be the most common pathology of the eye, diagnosed in 33.5 % of schoolchildren. The most frequent was low myopia claiming 65.4 % of myopic cases, followed by moderate myopia (28.5 %) and high myopia (6.1 %). The highest occurrence of myopia was revealed in 11th and 8th grade students (respectively, 55.8 and 40,0 cases per 100 examined subjects). It was found out that the share of more severe myopia stages (moderate and high) in increasing in older age groups 5th-grade to 11th-grade students. We also showed that myopia prevalence is connected with head and spine injuries in the case history.Conclusion. Educational facilities need to introduce an effective system of myopia prevention and means of progression reduction.
Strategically oriented correction of mixed astigmatism in children
Authors: Tarutta E. P. 
Published: July 2023

Purpose: evaluation of the remote functional and refractive results of mixed astigmatism correction in preschool children with “plus” cylinders in the framework of a long-time longitudinal study.Material and methods. 38 children (75 eyes) aged 1.5–7 years (averagely 4.2 years) with mixed astigmatism of 0.75 to 4.25 D (averagely 1.85 D) were followed up for 6-15 (averagely 7.3) years. At the first examination, all children were prescribed to permanently wear (+) cylinders of 0.5 D to 3.5 D. Over the follow-up period, (+) Cyl could be weakened in 24 eyes (32 %) due to a decrease in astigmatism, while (-) Sph had to be added in 24 eyes (32 %). due to an increased refraction. In cases when the full correction using a “plus” cylinder left an excessively large myopic defocus, the power of the “plus” cylinder was reduced so as not to add a “minus” sphere, and a second pair of glasses was prescribed for near vision, which offered a full correction of astigmatism with the “plus” cylinder.Results. After 6–15 years, astigmatism changed in 85 % of the examined eyes: it increased in 7 eyes (averagely, by 0.3 D) and decreased in 53 (averagely, by 0.9 D, p < 0.05; with the maximum reduction of 2.75 D). The spheric-equivalent refraction changed in 51 % of eyes, with an average increase of 0.53 D. The maximum increase of refraction was 2.8 D, while the maximum drop was 1.4 D. Visual acuity of the children who wore the prescribed eyeglasses permanently, showed after two years an increase, average achieving the level of 0.84, which by the end of the follow-up period achieved 0.99.Conclusion. The proposed plan of mixed astigmatism correction, which preserves residual weak myopic defocus, fully ensured both tactical and strategic effects: prevention and elimination of amblyopia, and containment of refraction myopization.
The Metformin Immunoregulatory Actions in Tumor Suppression
and Normal Tissues Protection
Authors: Gupta Jitendra , Jalil Abduladheem Turki , Abd Alzahraa Zahraa Hamzaa , Aminov Zafar , Alsaikhan Fahad , Ramírez-Coronel Andrés Alexis , Ramaiah Pushpamala , Najafi Masoud 
Published: July 2023

:
The immune system is the key player in a wide range of responses in normal tissues and tumors to
anticancer therapy. Inflammatory and fibrotic responses in normal tissues are the main limitations
of chemotherapy, radiotherapy, and also some newer anticancer drugs such as immune checkpoint
inhibitors (ICIs). Immune system responses within solid tumors including anti-tumor and tumor-
promoting responses can suppress or help tumor growth. Thus, modulation of immune cells
and their secretions such as cytokines, growth factors and epigenetic modulators, pro-apoptosis
molecules, and some other molecules can be suggested to alleviate side effects in normal tissues
and drug-resistance mechanisms in the tumor. Metformin as an anti-diabetes drug has shown intriguing
properties such as anti-inflammation, anti-fibrosis, and anticancer effects. Some investigations
have uncovered that metformin can ameliorate radiation/chemotherapy toxicity in normal
cells and tissues through the modulation of several targets in cells and tissues. These effects of metformin
may ameliorate severe inflammatory responses and fibrosis after exposure to ionizing radiation
or following treatment with highly toxic chemotherapy drugs. Metformin can suppress the activity
of immunosuppressive cells in the tumor through the phosphorylation of AMP-activated protein
kinase (AMPK). In addition, metformin may stimulate antigen presentation and maturation of
anticancer immune cells, which lead to the induction of anticancer immunity in the tumor. This review
aims to explain the detailed mechanisms of normal tissue sparing and tumor suppression during
cancer therapy using adjuvant metformin with an emphasis on immune system responses.
Plant Materials for the Production of Functional Foods for Weight
Management and Obesity Prevention
Authors: Stabnikova Оlena , Paredes-López Octavio 
Published: July 2023

Abstract:
Obesity is a serious problem in the modern world and is considered a risk factor in the
development of many human diseases.

:
Consumption of low-calorie, low-fat diets, together with increased physical activity and a healthy
lifestyle, contribute a lot to the fight against obesity. Meanwhile, functional foods with a reduced
calorie content and enriched with substances useful for the human body may play a role as additional
helpers in weight management. In this review, general suggestions for the elaboration of foods
with plant-origin functional ingredients for weight management, which help the human body with
obesity prevention, based on human clinical trials, are proposed.

:
Including new ingredients of plant-origin for the preparation of traditional foods helps to have a
balanced diet and may contribute to weight management and obesity prevention.
Use of Fe3O4@MPTMS-Dithizone Magnetic Nanoparticles as Solid Phase Sorbent for Sensitive Analysis of Sibutramine Molecules in Herbal Slimming Products
Authors: Demir Özge , Ulusoy Halil İbrahim , Polat Ümmügülsüm , Ulusoy Songül 
Published: July 2023

Background:A new enrichment and sensitive determination method, which includes HPLCDAD analysis after Magnetic Solid Phase Extraction (MSPE), has been developed for trace analysis of Sibutramine molecules in herbal slimming products. Sibutramine is one of the most adulterated drug molecules in herbal products.Method:In the proposed method, Sibutramine molecules were pre-concentrated by using Fe3O4@MPTMS-Dithizone magnetic sorbent synthesized in our laboratory. Desorption of Sibutramine molecules from the sorbent phase was carried out by using acetonitrile: methanol (1:1) solvent in the presence of pH 8.0 buffer before chromatographic determinations.Results:Analytical parameters of the method, such as linear range, enrichment factor, and determination limit, were determined after optimizing experimental variables such as interaction time, desorption solvent, pH, etc. The sibutramine molecule was analyzed by isocratic elution of acetonitrile and KH2PO4 (pH 3.0, 0.05 M) (40:60) with a DAD detector at 223 nm wavelength. Limit of detection (LOD) value was calculated as 1.43 ng mL-1.Conclusion:Relative standard deviations (RSD) were below 3.20% for determinations of model solutions, including 100 ng mL-1 of Sibutramine. Finally, the developed method has been applied to herbal slimming tea samples with quantitative recovery experiments.
Fetal Health Classification using LightGBM with Grid Search Based Hyper Parameter Tuning
Authors: Nagabotu Vimala , Namburu Anupama 
Published: July 2023

Background:
Fetal health monitoring throughout pregnancy is challenging and complex.
Complications in the fetal health not identified at the right time lead to mortality of the fetus
as well the pregnant women. Hence, obstetricians check the fetal health state by monitoring the fetal
heart rate (FHR). Cardiotocography (CTG) is a technique used by obstetricians to access the
physical well-being of fetal during pregnancy. It provides information on the fetal heart rate and
uterine respiration, which can assist in determining whether the fetus is normal or suspect or pathology.
CTG data has typically been evaluated using machine learning (ML) algorithms in predicting
the wellness of the fetal and speeding up the detection process.

Methods:
In this work, we developed LightGBM with a Grid search-based hyperparameter tuning
model to predict fetal health classification. The classification results are analysed quantitatively
using the performance measures, namely, precision, Recall, F1-Score, and Accuracy Comparisons
were made between different classification models like Logistic Regression, Decision Tree, Random
Forest, k-nearest neighbors, Bagging, ADA boosting, XG boosting, and LightGBM, which
were trained with the CTG Dataset obtained by the patented fetal monitoring system of 2,216 data
points from pregnant women in their third trimester available in the Kaggle dataset. The dataset contains
three classes: normal, suspect, and pathology. Our proposed model will give better results in
predicting fetal health classification.

Results:
In this paper, the performance of the proposed algorithm LightGBM is compared and experimented
with various Machine learning Techniques namely LR, DT, RF, KNN, Boosting, Ada
boosting, and XG Boost and the classification accuracy of the respective algorithms are 84%, 94%,
93%, 88%, 94%, 89%, 96%.The LightGBM achieved a performance of 97% and outperforms the
former models.

Conclusion:
The LightGBM-based fetal health classification has been presented. Ensemble models
were applied to the FHR dataset and presented the hybrid algorithm, namely Light GBM, and its
application to fetal health classification. LightGBM has advantages that include fast training, improved
performance, scale-up capabilities, and lesser memory usage than other ensemble models.
The proposed model is more consistent and superior to other considered machine learning models
and is suitable for the classification of fetal health based on FHR data. Finally, the outcomes of the
multiple methods are compared using the same training and test data in order to verify the efficiency
of LightGBM. The model can be further enhanced by making it hybrid by combining the advantages
of different models and optimization techniques.
Perbandingan Kualitas Sponge Cake Berbahan Dasar Tepung Terigu dan Tepung Porang
Authors: Hartati Miftahul Jannah , Sudiarta I Nyoman 
Published: July 2023

Kebiasaan masyarakat indonesia yang cukup gemar mengonsumsi sponge cake semakin membuat eksestensi sponge cake semakin melejit. Penelitian ini dilakukan untuk mengetahui perbandingan kualitas sponge cake berbahan dasar tepung porang dan tepung terigu dari segi warna, aroma, rasa, dan tekstur. Jenis penelitian yang digunakan adalah penelitian eksperimen dengan mixed method. Data kualitatif yang diperoleh dari hasil observasi dan kuisioner. Sedangkan data kuantitatif diperolehndari hasil uji organoleptic menggunakan uji Mann-Whitney. Penalis dari penelitian ini terdiri dari 20 orang masyarakat biasa dan 10 orang chef. Berdasarkan uji organoleptic melalui uji Man-Whitney didapatkan hasil bahwa dari segi aroma dan rasa menunjukan tidak ada perbedaan yang nyata antara sponge cake berbahan dasar tepung porang dan sponge cake berbahan dasar tepung terigu. Dari segi warna dan tekstur terdapat perbedaan yang nyata antara sponge cake berbahan dasar tepung porang dan sponge cake berbahan dasar tepung terigu.

The habit of Indonesian people who are quite fond of consuming sponge cake increasingly makes the existence of sponge cake skyrocket. This study was conducted to compare the quality of sponge cake made from porang flour and wheat flour in terms of color, aroma, taste, and texture. The type of research used is experimental research with mixed method. Qualitative data obtained from observations and questionnaires. While quantitative data were obtained from the results of organoleptic tests using the Mann-Whitney test. The authors of this study consisted of 20 ordinary people and 10 chefs. Based on the organoleptic test through the Man-Whitney test, the results showed that in terms of aroma and taste there was no significant difference between sponge cake made from porang flour and sponge cake made from wheat flour. In terms of color and texture, there are significant differences between sponge cake made from porang flour and sponge cake made from wheat flour.
Olahan Buah Anggur Hitam Lokal Menjadi Selai
Authors: Depiyani Ni Kadek , Muliadiasa I Ketut 
Published: July 2023

Olahan anggur hitam lokal menjadi selai adapun tujuan dari penelitian anggur hitam sebagai selai adalah untuk mengetahui kualitas selai yang berbahan dasar anggur hitam dari segi rasa,aroma,warna dan tekstur, kemudia untuk mengetahui daya tahan serta menganalisis biaya yang diperlukan dalam pembuatan selai anggur hitam. Pendekata penelitian yang digunakan adalah penelitian eksperimen, penelitian eksperimen ini dilakukan dengan membuat selai anggur hitam, kemudian diuji oleh 30 panelis dengan tes organoleptik, observasi dan analisis biaya. Hasil penelitian ini berupa kualitas selai anggur hitam adalah enak dari segi rasa, beraroma sedap, tekstur yang lembut serta memiliki penampilan yang menarik. Dari hasil uji daya tahan selai anggur hitam, mampu bertahan selama 2 bulan dengan kualitas masih baik di dalam lemari pendingin (kulkas) dan dapat bertahan di suhu ruangan 20o -25 o selama 2 minggu dengan kualitas masih baik. Harga jual produk adalah Rp 16.675.

Processed local black grapes into jam. The purpose of the research on black grapes as jam is to determine the quality of jam made from black grapes in terms of taste, aroma, color and texture, then to determine the durability and analyze the costs required in making black grape jam. The research approach used is experimental research, this experimental research was conducted by making black grape jam, then tested by 30 panellists with organoleptic tests, observation and cost analysis. The results of this study are the quality of black grape jam is delicious in terms of taste, delicious aroma, soft texture and has an attractive appearance. From the results of the durability test of black grape jam, it can last for 2 months with good quality in the refrigerator (refrigerator) and can survive at room temperature 20o -25o for 2 weeks with good quality. The selling price of the product is Rp. 16,675.
Perbandingan Kualitas Roti dengan Menggunakan Mother Dough dan Instant Yeast
Authors: Anggreni Ni Made Alit , Kuntariati Utik 
Published: July 2023

Roti adalah hasil dari pencampuran tepung dan air yang difermentasikan menggunakan bahan pengembang seperti instant yeast dan mother dough. Penelitian ini bertujuan untuk mengetahui pengaruh bahan pengembang pada roti yang menggunakan mother dough dengan instant yeast dari segi rasa, aroma, warna dan tekstur serta untuk mengetahui analisis cost roti yang menggunakan mother dough dengan roti yang menggunakan instant yeast. Metode penelitian yang digunakan adalah eksperimen. Dengan data yang diperoleh dari hasil observasi dan kuesioner. Sedangkan data kuantitatif di peroleh dari organoleptik. Panelis dari penelitian ini terdiri dari 20 orang yaitu 10 orang chef dan 10 orang masyarakat biasa. Berdasarkan uji organoleptik dapat disimpulkan bahwa tidak ada perbedaan yang nyata dari segi aroma pada roti menggunakan mother dough dan roti yang menggunakan instant yeast. Sedangkan dari segi warna, rasa dan tekstur dapat dikatakan bahwa ada perbedaan yang nyata pada roti menggunakan mother dough dan instant yeast.

Bread is the result of mixing flour and water which is fermented using a developer such as instant yeast and mother dough. This study aims to determine the effect of the developer on bread using mother dough with instant yeast in terms of taste, aroma, color and texture and to determine the cost analysis of bread using mother dough with bread using instant yeast. The research method used is experimental. With data obtained from observations and questionnaires. While quantitative data obtained from organoleptic. The panelists of this study consisted of 20 people, namely 10 chefs and 10 ordinary people. Based on the organoleptic test, it can be concluded that there is no significant difference in terms of aroma in bread using mother dough and bread using instant yeast. Meanwhile, in terms of color, taste and texture, it can be said that there is a significant difference in bread using mother dough and instant yeast.