bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic alcohol metabolism results in DNA repair infidelity and cell cycle‐induced senescence in neurons
Authors: Sun Jacquelyne Ka‐Li , Wu Deng , Wong Genper Chi‐Ngai , Lau Tsun‐Ming , Yang Meigui , Hart Ronald P. , Kwan Kin‐Ming , Chan Ho Yin Edwin , Chow Hei‐Man 
Published: January 2023

AbstractChronic binge‐like drinking is a risk factor for age‐related dementia, however, the lasting and irreversible effect of alcohol on the brain remains elusive. Transcriptomic changes in brain cortices revealed pro‐ageing hallmarks upon chronic ethanol exposure and these changes predominantly occur in neurons. The changes are attributed to a prioritized ethyl alcohol oxidation in these cells via the NADPH‐dependent cytochrome pathway. This hijacks the folate metabolism of the 1‐carbon network which supports the pathway choice of DNA repair via the non‐cell cycle‐dependent mismatch repair networks. The lost‐in‐function of such results in the de‐inactivation of the less preferred cell cycle‐dependent homologous recombination (HR) repair, forcing these post‐mitotic cells to re‐engage in a cell cycle‐like process. However, mature neurons are post‐mitotic. Therefore, instead of successfully completing a full round of cell cycle which is necessary for the completion of HR‐mediated repair; these cells are arrested at checkpoints. The resulting persistence of repair intermediates induces and promotes the nuclear accumulation of p21 and cyclin B—a trigger for permanent cell cycle exits and irreversible senescence response. Supplementation of bioactive 5‐methyl tetrahydrofolate simultaneously at times with ethyl alcohol exposure supports the fidelity of the 1‐carbon network and hence the activity of the mismatch repair. This prevents aberrant and irreversible cell cycle re‐entry and senescence events of neurons. Together, our findings offer a direct connection between binge‐drinking behaviour and its irreversible impact on the brain, which makes it a potential risk factor for dementia.
Associations of parent–adolescent closeness with P3 amplitude, frontal theta, and binge drinking among offspring with high risk for alcohol use disorder
Authors: Pandey Gayathri , Kuo Sally I‐Chun , Horne‐Osipenko Kristina A. , Pandey Ashwini K. , Kamarajan Chella , de Viteri Stacey Saenz , Kinreich Sivan , Chorlian David B. , Kuang Weipeng , Stephenson Mallory , Kramer John , Anokhin Andrey , Zang Yong , Kuperman Samuel , Hesselbrock Victor , Schuckit Marc , Dick Danielle , Chan Grace , McCutcheon Vivia V. , Edenberg Howard , Bucholz Kathleen K. , Meyers Jacquelyn L. , Porjesz Bernice 
Published: January 2023

AbstractBackgroundParents impact their offspring's brain development, neurocognitive function, risk, and resilience for alcohol use disorder (AUD) via both genetic and socio‐environmental factors. Individuals with AUD and their unaffected children manifest low parietal P3 amplitude and low frontal theta (FT) power, reflecting heritable neurocognitive deficits associated with AUD. Likewise, children who experience poor parenting tend to have atypical brain development and greater rates of alcohol problems. Conversely, positive parenting can be protective and critical for normative development of self‐regulation, neurocognitive functioning and the neurobiological systems subserving them. Yet, the role of positive parenting in resiliency toward AUD is understudied and its association with neurocognitive functioning and behavioral vulnerability to AUD among high‐risk offspring is less known. Using data from the Collaborative Study on the Genetics of Alcoholism prospective cohort (N = 1256, mean age [SD] = 19.25 [1.88]), we investigated the associations of closeness with mother and father during adolescence with offspring P3 amplitude, FT power, and binge drinking among high‐risk offspring.MethodsSelf‐reported closeness with mother and father between ages 12 and 17 and binge drinking were assessed using the Semi‐Structured Assessment for the Genetics of Alcoholism. P3 amplitude and FT power were assessed in response to target stimuli using a Visual Oddball Task.ResultsMultivariate multiple regression analyses showed that closeness with father was associated with larger P3 amplitude (p = 0.002) and higher FT power (p = 0.01). Closeness with mother was associated with less binge drinking (p = 0.003). Among male offspring, closeness with father was associated with larger P3 amplitude, but among female offspring, closeness with mother was associated with less binge drinking. These associations remained statistically significant with father's and mothers' AUD symptoms, socioeconomic status, and offspring impulsivity in the model.ConclusionsAmong high‐risk offspring, closeness with parents during adolescence may promote resilience for developing AUD and related neurocognitive deficits albeit with important sex differences.
Public Opinion and Presidents’ Unilateral Policy Agendas
Authors: Rogowski Jon C. 
Published: January 2023

AbstractUnilateral power is an important source of policy change for contemporary presidents. In contrast with scholarship that examines the institutional constraints on presidents’ exercise of unilateral authority, I consider presidents’ unilateral behavior in a framework of political accountability. I argue that presidents have incentives to incorporate the public's policy priorities in their unilateral agendas. I examine this account using panel data on executive orders and public opinion across issue areas from 1954 to 2018. Across a variety of model specifications and estimation strategies, I find evidence that patterns of executive action reflect the public's policy priorities. Presidents issue greater numbers of unilateral directives on issues that gain public salience, particularly on issues that are more familiar to the public and when issuing more policy‐significant directives. These findings suggest that accountability mechanisms structure how presidents exercise unilateral power and have normative implications for considering presidential unilateralism in a separation‐of‐powers system.
Et si on changeait la musique? Déterminants sociaux des préférences pour le hip‐hop, le rap et les musiques urbaines en Grande Bretagne
Authors: Boucher Aurélien , Yan Ren 
Published: January 2023

ABSTRACTThis article examines the social determinants of hip‐hop culture in Britain. Using data from the Great Britain Class Survey and drawing on work done over the last twenty years on the roots and development of hip‐hop culture and rap music in Britain, it shows that preference for hip‐hop music has a dual elective affinity with status‐dominated groups in postcolonial Britain ̶ such as social agents identifying as “Black, Black British, Caribbean and African” and the dominated classes. Through this object of study, it is possible to rethink the heuristic character of the distinction between class and status.
Boris knockout eliminates AOM/DSS‐induced in situ colorectal cancer by suppressing DNA damage repair and inflammation
Authors: Zuo Bo‐Wen , Yao Wan‐Xin , Fang Meng‐Die , Ren Juan , Tu Ling‐Lan , Fan Run‐Jie , Zhang Yan‐Mei 
Published: January 2023

AbstractThe Brother of Regulator of Imprinted Sites (BORIS, gene symbol CTCFL) has previously been shown to promote colorectal cancer cell proliferation, inhibit cancer cell apoptosis, and resist chemotherapy. However, it is unknown whether Boris plays a role in the progression of in situ colorectal cancer. Here Boris knockout (KO) mice were constructed. The function loss of the cloned Boris mutation that was retained in KO mice was verified by testing its activities in colorectal cell lines compared with the Boris wild‐type gene. Boris knockout reduced the incidence and severity of azoxymethane/dextran sulfate‐sodium (AOM/DSS)‐induced colon cancer. The importance of Boris is emphasized in the progression of in situ colorectal cancer. Boris knockout significantly promoted the phosphorylation of γH2AX and the DNA damage in colorectal cancer tissues and suppressed Wnt and MAPK pathways that are responsible for the callback of DNA damage repair. This indicates the strong inhibition of colorectal cancer in Boris KO mice. By considering that the DSS‐promoted inflammation contributes to tumorigenesis, Boris KO mice were also studied in DSS‐induced colitis. Our data showed that Boris knockout alleviated DSS‐induced colitis and that Boris knockdown inhibited the NF‐κB signaling pathway in RAW264.7 cells. Therefore Boris knockout eliminates colorectal cancer generation by inhibiting DNA damage repair in cancer cells and relieving inflammation in macrophages. Our findings demonstrate the importance of Boris in the development of in situ colorectal cancer and provide evidence for the feasibility of colorectal cancer therapy on Boris.
3D printed bionic ear and microtia‐anotia: Medical and forensic implications
Authors: Rani Deepika , Chitara Nandini , Kanchan Tanuj , Krishan Kewal 
Published: January 2023

AbstractAdvances in science and technology result in continuous upgrading of the medical and clinical fields. These upgrades have been beneficial to many patients suffering from congenital and developmental diseases causing compromised functionality as well as the structural integrity of the affected organs. One such congenital anomaly is the microtia‐anotia spectrum, which results in deformities of the external ear, affecting the hearing capability of an individual. The collaboration and integration of electronics in human biology are exemplified by the development of a 3D printed cyborg bionic ear from the patient's own cells, which is implanted to ameliorate microtia and improve the patient's hearing capacity. Since the late nineteenth century, forensic scientists have explored the external ear, establishing the significance of ear biometrics in the identification process. Similarly, ear prints can also play an important role in identifying the felon of a crime. In this regard, we examine the structure and functionality of implanted ears. This communication is an attempt to enlighten investigators on the forensic importance and limitations of the use of bionic ears for identification.
The roles of polymer relaxation phenomena, aqueous dye solubility and the physical properties of water in the mechanism of adsorption of a disperse dye on poly(ethylene terephthalate) fibres: Part 4 further aspects related to polymer relaxation phenomena
Authors: Burkinshaw Stephen M. , Liu K. 
Published: January 2023

AbstractTo further investigate the contribution of polymer relaxation times to the mechanism of disperse dye adsorption on poly(ethylene terephthalate) fibres, the temperature‐dependent uptake of Teratop Yellow HL‐G 150% on both cotton and polyamide 66 fabrics at temperatures between 30 and 130°C was compared with that on poly(ethylene terephthalate) fabric. Although uptake of the commercial grade dye on polyester fabric is governed by the thermally regulated, broad glass transition of the water‐saturated poly(ethylene terephthalate) substrate, as this was not observed for either cotton or nylon 66 fabrics, the respective cellulose or polyamide 66 polymer glass transition does not present a major thermal impediment to dye uptake over the wide range of dyeing temperatures used. This is because the onset and end‐set temperatures of the glass transition of the water‐plasticised poly(ethylene terephthalate) material reside within the range of dyeing temperatures employed, whereas those of the water‐plasticised cotton and polyamide materials occur below the lowest dyeing temperature examined (30°C). The thermal dependency of disperse dye solubility also likely makes a meaningful contribution to the temperature‐dependent dye uptake observed for each type of fibre.
The ethical dimensions of everyday alcohol and other drug work: An empirical ethics investigation
Authors: Silkoff David , Chenhall Richard , Guillemin Marilys , McDougall Rosalind 
Published: January 2023

AbstractIntroductionThe complex and contentious nature of alcohol and other drug (AOD) clinical work affords the likelihood of significant ethical dimensions. However, little attention has been paid to clinicians' perspectives of ethics in their practice within AOD settings. This potentially neglects an important aspect of AOD clinical work.MethodsWe used an insider empirical ethics methodology, where the first author (DS) concurrently worked as an AOD clinician in the research setting. Participants were 30 experienced AOD clinicians, working within a large specialist AOD service in Victoria, Australia. We used three qualitative data collection methods: moral conversation, involving semi‐structured interviews; moral participation, involving the first author reflecting on his own ethical practices; and participant‐observation, involving observation of clinical meetings. We used Applied Thematic Analysis to analyse the data.ResultsAlthough participants rarely used explicitly ethical language to describe their work, they described four ethical goals: helping clients to access AOD care and treatment; facilitating change in clients' lives; challenging stigma; and keeping people safe. We argue that these clinical goals should also be conceptualised as ethical goals.Discussion and ConclusionsEthics is an integral component of everyday AOD work. Our findings had some overlap with established ethical principles. Participants demonstrated expertise in engaging with ethical dimensions, without using ethical language. Given the limited attention paid to ethics in AOD clinical settings, increasing the focus on ethics in everyday clinical practice is an important contribution to future AOD clinical work. Its absence negates important aspects of care for clients.
Integrated safety and efficacy analysis of dasiglucagon for the treatment of severe hypoglycaemia in individuals with type 1 diabetes
Authors: Heller Simon , Battelino Tadej , Bailey Timothy S. , Pieber Thomas R. , Hövelmann Ulrike , Plum‐Mörschel Leona , Melgaard Anita E. , Aronson Ronnie , DiMeglio Linda A. , Johansen Thue , Danne Thomas 
Published: January 2023

AbstractAimsTo perform an integrated analysis of the safety and efficacy of dasiglucagon, a glucagon analogue available in a ready‐to‐use aqueous formulation, to treat severe hypoglycaemia (SH) in type 1 diabetes (T1D).Materials and MethodsAn integrated analysis of dasiglucagon safety was conducted on data from two placebo‐controlled trials (placebo‐controlled pool) and two placebo‐controlled and four non‐placebo‐controlled trials (broad pool) in adults with T1D. An integrated analysis of dasiglucagon efficacy was conducted of pooled data and within demographic subgroups from the two placebo‐controlled and two non‐placebo‐controlled trials in adults with T1D.ResultsDasiglucagon had a similar safety and tolerability profile to that of reconstituted glucagon. In the placebo‐controlled datasets, no serious adverse events (AEs), AEs leading to withdrawal from the trial, or deaths were reported. The most common causally related AEs were nausea (56.5%) and vomiting (24.6%). The broad pool safety analysis showed similar results. Dasiglucagon efficacy in time to plasma glucose recovery from insulin‐induced SH was similar to that of reconstituted glucagon (median 10.0 and 12.0 minutes, respectively) and superior to placebo (median 40.0 minutes; P < 0.0001). The median recovery time was consistent across all placebo‐controlled trial subgroups.ConclusionsDasiglucagon was well tolerated and effective as a rapid rescue agent for insulin‐induced SH in people with T1D.
Radiological evolution of progestogen‐induced meningioma: A monocentric retrospective study
Authors: Ahmed‐Khalifa Taghla , Gillet Romain , Blonski Marie , Rech Fabien , Fresse Audrey , Gillet Pierre , Taillandier Luc , Petitpain Nadine 
Published: January 2023

AbstractCyproterone acetate (CPA) is known to induce meningioma, and recently, nomegestrol acetate (NMA) and chlormadinone acetate (CMA) were also involved. Progestagen‐induced meningioma management starts with progestogen discontinuation and is either interventional (surgery and/or radiotherapy) or conservative (clinical and MRI radiological follow‐up). We performed a retrospective volumetric radiological outcomSe study of progestogen‐induced meningiomas diagnosed in our hospital. We analysed progestogen‐related meningiomas diagnosed until 30 June 2021, with at least one diagnostic and one follow‐up MRI results. Meningioma volumes were centrally retrospectively measured using a T1‐weighted 3D millimeter sequence with gadolinium injection on a postprocessing console. We analysed 98 meningiomas of 38 females and one transgender (male‐to‐female), of which 25 (64.1%) had taken CPA, seven (17.9%) NMA, three (7.7%) CMA, and four (10.2%) several progestogens. Eleven patients (24 meningiomas) underwent interventional management, seven patients had meningiomas followed by conservative or interventional management, and 21 patients (51 meningiomas) had only conservative management. Of these 21 patients, 17 had discontinued their progestogen less than 6 months before, of which 14 (82.3%) had decreased or stable meningioma(s) during a 24‐month median follow‐up (3 to 75) period. Overall, four of the 39 patients experienced meningioma progression (three during conservative treatment and one after surgery), including two patients who had continued NMA or CMA treatment several years after diagnosis. Our study confirms a generally favourable outcome of progestogen‐related meningioma after conservative treatment, especially for CPA. It also underlines the need for progestogen discontinuation at meningioma diagnosis.
An optical technique based on silicate glass sintering for temperature mapping
Authors: Burke Noah , Panoutsopoulos Panagiotis , Gregory Otto J. 
Published: January 2023

AbstractThermal paints have been used for decades by the gas turbine engine community to map surface temperature with low resolution. A novel thermal paint based on the sintering of a lead‐silicate glass powder was developed that can map maximum temperature with high resolution (±5°C) over a 60°C range beginning at the glass transition temperature (). The paint exhibited excellent adhesion to nickel‐based superalloy components due to similar coefficients of thermal expansion between the superalloy and glassy ceramic coating. An optical transition was qualitatively and quantitatively observed using scanning electron microscopy, ultraviolet‐visible (UV‐VIS) reflectance spectroscopy, and visual inspection. UV‐VIS reflectance spectroscopy was used to confirm the optical transition observed by the naked eye and quantitatively assess the transition of the thermal paint with high resolution. This technique for obtaining high resolution experimental temperature maps can aid the performance, efficiency, and reliability of gas turbine engines.
Parental recall bias in observational studies: Child dental service use
Authors: Stormon Nicole , Sexton Christopher 
Published: January 2023

AbstractBackgroundParents are frequently used to recall events of exposure and disease as a proxy for their children in observational health research.AimTo assess the validity of parental recall of children's utilisation of dental services.DesignParents in the Longitudinal Study of Australian Children (LSAC) were asked to recall their children's overall dental service use in the previous year and whether the study child had received fillings or extractions due to decay in the previous 2 years. True positives were identified through parents who correctly recalled child dental service utilisation with actual dental treatment received in a linked dataset.ResultsOf the 10 090 participants from the LSAC, 1290 study children had linked dental treatment data eligible for inclusion in this study. The absolute true‐positive rate for parental recall of dental service use in the previous year was 82% (n = 1263). Overall true‐positive percentages were lower for recall of fillings (40%) and extractions (7%) in the previous 2 years. Increasing number of recall days was associated with the rate of true‐positive recall adjusted for other factors in all three models.ConclusionAccuracy of parental recall for tooth fillings and extractions was low. The use of parental recall for specific dental treatment over a time span of 2 years in further research is not recommended.
Analytical model for strength of MAX phases considering high‐temperature oxidation and plastic deformation
Authors: Deng Yong , Wang Huanfang , Hao Yi , Zhang Chao , Shao Jiaxing , Li Weiguo 
Published: January 2023

AbstractAs a promising high‐temperature material, MAX phases have attracted much attention owing to their combined merits of metals and ceramics. In this study, a temperature‐dependent analytical model for prediction of the strength of MAX phases considering high‐temperature oxidation and plastic deformation was proposed. A relationship among the strength, Young's modulus, strain‐hardening exponent, crack size, and temperature was established. The accuracy of the model was verified by a comparison between the model predictions and available experimental data. The proposed analytical model can provide a straightforward and effective way to predict the strength of MAX phases over a wide range of temperatures. Moreover, the quantitative effects of oxidation time, strain‐hardening exponent, and Young's modulus on the strength, as well as their evolution with temperature, were analyzed. The findings of this study would be useful for the high‐temperature strength prediction and design of MAX phase materials.
Family oriented intervention for families of adolescents with attention deficit hyperactivity disorder: A feasibility study
Authors: Baldursdottir Ingibjorg M. , Petursdottir Asta B. , Svavarsdottir Erla K. 
Published: January 2023

AbstractPurposeBased on eight research criteria, this study examines the feasibility of a 5‐week Family Strength‐Oriented Therapeutic Conversation (FAM‐SOTC) for caregivers of adolescents diagnosed with attention deficit hyperactivity disorder (ADHD); this intervention aims to improve outcomes of both caregivers and adolescents.Design and MethodsThe FAM‐SOTC intervention was implemented at an adolescent psychiatric outpatient unit with 10 caregivers of 10 adolescents diagnosed with ADHD. The feasibility criteria were addressed through survey responses, diary reports, and a one‐group pre‐ and posttest quasi‐experimental design.FindingsThe assessment of eight feasibility criteria showed promising results for the further evaluation of the intervention.Practical ImplicationsThis feasibility study has produced promising results, which represent a step toward a more extensive study, designed to evaluate a protocol that may offer educational and supportive programs for families of adolescents with ADHD, enhancing their self‐management behavior. Further studies are warranted to test the FAM‐SOTC intervention using a larger sample.