bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low Aspartate Aminotransferase (AST)/Alanine Aminotransferase (ALT) Ratio Associated with Increased Cardiovascular Disease and its Risk Factors in Healthy Japanese Population
Authors: Higashitani Michiaki , Mizuno Atsushi , Kimura Takeshi , Shimbo Takuro , Yamamoto Kazuki , Tokioka Sayuri , Kobayashi Daiki 
Published: December 2022

Aims: This study aimed to evaluate the association between aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio and cardiovascular disease, and risk factors in a healthy Japanese population.
Methods: A retrospective cohort study was conducted at St. Luke’s International Hospital, Tokyo, Japan, between 2005 and 2018. We included all participants who visited the hospital for voluntary health checkups. Our primary outcome was the development of cardiovascular disease, and the secondary outcomes were cardiovascular risk factors. We grouped the participants into quartiles (Qs) according to their baseline AST/ ALT ratios and examined the outcomes of patients in each group.
Results: 87,740 participants were included in this study. The mean age of the participants was 44.9 years [standard deviation (SD): 12.1], and 43,191 (49.2%) were men. The mean AST and ALT levels were 21.7 IU/L (SD 10.0) and 22.4 IU/L (SD 16.5), respectively, resulting in a mean AST/ALT ratio of 1.1 (0.4). During the median follow-up of 1,829 days (interquartile range 756–3,470), 1,493 (1.7%) participants developed cardiovascular disease, 831 (1%) experienced ischemic heart disease, and 723 (0.8%) experienced strokes. Those in the Q1 AST/ALT ratio group had significantly higher hazard ratios compared to those in the Q3 AST/ ALT ratio group [adjusted hazard ratio (HR)=1.32, 95% confidence interval (CI): 1.12-1.56 for cardiovascular disease; HR=1.36, 95%CI: 1.09-1.68 for ischemic heart disease; HR=1.28, 95%CI: 1.00-1.65 for stroke]. However, those belonging to the Q4 or Q5 AST/ALT ratio groups was not statistically different for primary outcomes compared to the Q3 AST/ALT ratio group. In contrast, the adjusted HRs for all secondary outcomes decreased in a dose-dependent manner as the AST/ALT ratio increased.
Conclusions: A Q1 AST/ALT ratio was associated with an increased risk of cardiovascular disease compared to the Q3 AST/ALT ratio in the Japanese population, which is in contrast with the Western population. In our study, Q4 or Q5 AST/ALT ratios were not associated with cardiovascular disease compared to the Q3 AST/ ALT ratio. As for cardiovascular risk factors, the risk decreased as the AST/ALT ratio increased.
Do Patient Delay and Diagnostic Delay Influence Long Term Survival in Patients with Gastric Cancer?
Authors: Puia Aida , Schlanger Diana , Fetti Alin , Popa Calin , Necula Alexandru , Al Hajjar Nadim 
Published: December 2022

Background and Aims: Gastric cancer is one of the most common malignancies, with an aggressive evolution and a poor long-term prognosis. No screening program is available in Europe for this pathology; therefore, the delay from the appearance of the first symptom until the initiation of treatment might influence the prognosis of gastric cancer patients. We aimed to investigate the impact on the prognosis of the delay in the presentation and diagnosis in patients with gastric adenocarcinoma.
Methods: Our study is a retrospective, single-center, observational cohort study, based on patients diagnosed with gastric adenocarcinoma and operated in our institution between 2013 and 2021. We have defined patient delay as the time from the onset of symptoms to the first encounter with a health care provider and diagnosis delay as the time from the first consultation with a health care provider to the establishment of the final diagnosis.
Results: A total of 671 patients were included in our study. The survival rate at 5 years was 55% for the patients operated with curative intent and 7.4% for the patients operated with palliative intent. Patient delay and diagnosis delay were not correlated with the overall survival. A lower survival was observed for patients admitted through transfer (p<0.001) or the emergency department (p<0.001). No statistically significant relationship was identified between patient delay or diagnosis delay and the age, gender or area of origin of patients. Patients that experienced melena or hematemesis had a shorter patient delay, with a highly significant statistical relationship (p<0.01). Patients that experienced nausea, epigastric pain, palpable epigastric tumor mass or anorexia also had a highly significant statistical relationship between the symptoms and the patient delay interval.
Conclusions: The overall survival is not influenced by the patient delay or diagnosis delay. An earlier presentation was correlated with some specific exhibited symptoms: upper gastro-intestinal bleeding, abdominal pain, palpable epigastric tumor, nausea.
Replacement of Adalimumab Originator to Adalimumab Biosimilar for a Non-Medical Reason in Patients with Inflammatory Bowel Disease: A Real-life Comparison of Adalimumab Biosimilars Currently Available in Italy
Authors: Tursi Antonio , Mocci Giammarco , Cuomo Antonio , Ferronato Antonio , Elisei Walter , Picchio Marcello , Maconi Giovanni , Scaldaferri Franco , Papa Alfredo , Italian group for switch of biologics - , Allegretta Leonardo , Aragona Giovanni , Bianco Maria Antonia , Colucci Raffaele , Della Valle Nicola , Faggiani Roberto , Forti Giacomo , Gaiani Federica , Giorgetti GianMarco , Graziani Maria Giovanna , Lofano Katia , Lorenzetti Roberto , Larussa Tiziana , Penna Antonio , Bassotti Gabrio , Cazzato Alessia Immacolata , Chiri Stefania , Clemente Valeria , Cocco Andrea , De’ Angelis Gianluigi , Donnarumma Laura , Graziosi Camilla , Le Grazie Marco , Luzza Francesco , Meucci Costantino , Monterubbianesi Rita , Pagnini Cristiano , Perazzo Patrizia , Pica Roberta , Pranzo Giuseppe , Rodino’ Stefano , Sacco Rodolfo , Sebkova Ladislava , Scarcelli Antonella , Serio Mariaelena , Napolitano Daniele , Pugliese Daniela , Schiavoni Elisa , Turchini Laura , Armuzzi Alessandro , Zampaletta Costantino 
Published: December 2022

Background and Aims: Adalimumab (ADA) biosimilars have been included into the therapeutic armamentarium of inflammatory bowel disease (IBD); however, comparative data on the efficacy and safety of the different ADA biosimilars after replacing the ADA originator for a non-medical reason remains scarce. We aimed to compare in a real-life setting the efficacy and safety of four ADA biosimilars SB5, APB501, GP2017, and MSB11022 in IBD patients after replacing the originator for a non-medical reason.
Methods: A multicenter retrospective study was performed on consecutive IBD patients, analyzing clinical, laboratory, and endoscopic data. The primary endpoints of the study were maintenance of clinical remission and safety of the different biosimilars.
Results: 153 patients were enrolled, 26 with UC and 127 with CD. Clinical remission was maintained in 124 out of 153 (81%) patients after a median (IQR) follow-up of 12 (6–24) months, without any significant difference between the four ADA biosimilars. ADA biosimilars dosage was optimized in five patients (3.3%). Loss of remission was significantly higher in UC patients (10/26 patients, 38.5%) than in CD patients (19/127 patients, 14.9%, p<0.025). Adverse events occurred in 12 (7.9%) patients; the large majority were mild.
Conclusions: No difference in efficacy and safety was found between ADA biosimilars when used to replace the ADA originator for a non-medical reason. However, in UC patients the replacement of ADA originator for this reason should be carefully assessed.
Edoxaban in patients with bioprostetic valve
Authors: Fazio Giovanni , Milana Gaspare , Schirò Piero 
Published: December 2022

Background: Nowadays the treatment with Direct Oral Anticoagulants (DOACs) and in particular with edoxaban in patients with Bioprosthetic Aortic Valve (BPAV) is unsupported by consistent data. We analyzed retrospectively our experience in this group of patients. Methods: The data of the present study were retrospectively obtained from 24 consecutive patients with BPVA evaluated for AF in a high-volume Italian cardiological center. We analyzed the data pulled from reports of patients with Nonvalvular Paroxymal Atrial Fibrillation (NVAF), that we entered in the Italian Registry of Drugs (AIFA registry). All patients were treated with edoxaban 60 mg for AF. At the time of the data collection, the average follow-up in valvular patients was 36 ± 3 months, with a median follow-up of 33 ± 6 months. Results: There were no major bleedings, strokes, systemic embolisms, or cardiovascular deaths reported. A single case of transitory ischemic event (6,25%) and a case of minor bleeding (6,25%) were reported during the follow-up. The complication rate was similar in patients with BPAV compared to that of the whole group of patients with fibrillation and there were no statistical differences (2.08% vs 1.37%; p: 0.36). Although the number is too small, transient ischemic attack appears to be more frequent in patients with BPAV than in the control group (p: 0.0046). Conclusion: In our experience, we used edoxaban in a group of 36 subjects with BPAV and AF: the event rate of this subpopulation was not different from that of all patients with AF included in the control group. Therefore, the results suggest that the use of edoxaban for AF in patients with BPVA appears to be safe and effective.
Trends in the Use of Procalcitonin at US Children’s Hospital Emergency Departments
Authors: Dorney Kate , Monuteaux Michael C. , Nigrovic Lise E. , Lipsett Susan C. , Nelson Kyle A. , Neuman Mark I. 
Published: December 2022

OBJECTIVES:
Procalcitonin (PCT) was approved by the Food and Drug Administration in 2016. We assessed changes in PCT utilization over time in emergency departments (EDs) at US Children’s Hospitals and identified the most common conditions associated with PCT testing.

METHODS:
We performed a cross-sectional study of children &lt;18 years of age presenting to 1 of 33 EDs contributing data to the Pediatric Health Information System between 2016 and 2020. We examined trends in PCT utilization during an ED encounter between institutions and over the study period. Using All Patients Refined Diagnosis Related Groups, we identified the most common conditions for which PCT was obtained (overall, and relative to the performance of a complete blood count).

RESULTS:
The overall rate of PCT testing increased from 0.2% of all ED visits in 2016 to 1.8% in 2020. Across hospitals, the proportion of ED encounters with PCT obtained ranged from 0.0005% to 4.3% with marked variability in overall use. Among children who had PCT testing performed, the most common diagnoses were fever (10.7%), infections of the upper respiratory tract (9.2%), and pneumonia (5.9%). Relative to the performance of a complete blood count, rates of PCT testing were highest among children with sepsis (28.7%), fever (21.4%), pulmonary edema/respiratory failure (17.3%), and bronchiolitis/respiratory syncytial virus pneumonia (15.6%).

CONCLUSIONS:
PCT utilization in the ED has increased over the past 5 years with variation between hospitals. PCT is most frequently obtained for children with respiratory infections and febrile illnesses.
Methodological Proposal for the Assessment of Company Sustainability in Transport Logistics
Authors: Fernandes Alexandre Chacon , Tagliaferro Evandro Roberto , Vanzela Luiz Sergio 
Published: December 2022

The sustainability of companies is a principle that is increasingly defining their development and growth, with the valuation of the market and products and services, having the principles of the United Nations Global Compact as the guidelines for achieving sustainability. In the case of a logistics for a transportation company, it is necessary to carry out a diagnosis of performance to then establish an action plan that aims at its sustainability, called Sustainable
Plan for Transport Logistics (SPTL). Therefore, the objective of this work was to develop a methodology for the diagnosis, allowing the company to classify its sustainability and guide it in the elaboration of the action plan in the short, medium and long term of the SPTL. The principle was to develop an objective method to classify the level of sustainability of a company based on a final score, determined by means of parameters modified from the principles of the
UN Global Compact, called &quot;principles of sustainability&quot;. The method was then applied to a transportation company located in the Northeast of São Paulo. We conclude that the proposed method allowed us to classify the company&#39;s sustainability as moderate, as well as to identify the points that need action to achieve full sustainability, acting with respect to the principles of human rights and labor, environment and anti-corruption.
Influence of Training Programmes on Access to County Vocational Education and Training Institutions in Makueni County, Kenya
Authors: Mutuku Ngulu Onesmus , Riechi Dr. Andrew , Obae Dr. Rose 
Published: December 2022

The purpose of this study was to investigate the influence of training programmes on access to County Vocational Education and Training institutions in Makueni County, Kenya. The study was informed by the existence of a large number of youths in the County who have not enrolled in CVETIs hence leading to high population of idle youths with low or no relevant employable skills which contributes to increased dependency ratio, high unemployment rates, engagement in drug and substance abuse and other social-evils. The study sought to investigate whether, the career guidance services influence access to County Vocational Education and Training Institutions in Makueni County, Kenya. The study was guided by Human Capital Theory (HCT). The study employed descriptive research design. The study targeted 28 registered Public Vocational institutions in Makueni County. The study used stratified simple random sampling and purposive sampling techniques to obtain a random sample of 21 managers, 87 instructors and 316 trainees drawn from 21 randomly selected Vocational institutions. Questionnaires, interview schedule and an observation check list were used to collect data. Data were processed and analyzed qualitatively and quantitatively. Quantitative analysis used descriptive and inferential statistics computed using a computer programme (SPSS version 23 computer package). Descriptive statistics were generated and used in describing and discussing the research findings. Statistical tests were done using a T-test and one-way analysis of variance (ANOVA) at 95% Confidence Interval of the difference (α=0.05). The finding of the study revealed that, vocational training courses have not kept the phase of advancing technology in the industry and they less meet the labour market requirements, hence not attracted prospective trainees who meet the minimum admission requirements. Based on this findings the study recommended that, there is need to re-plan the Vocational Education and Training curriculum in Kenya with the KCSE graduates in mind as opposed to their historical establishment as village youths polytechnics.
Impact of Risk Perception on Customer Purchase Intention in e-Commerce Platform
Authors: Li Jingyao , Nuangjamnong Chompu 
Published: December 2022

Purpose – This study aims to investigate the impact of risk perception on online purchase intention in e-commerce platforms.
Design/Methodology/Approach – This research uses secondary data analysis and an archival study approach to investigate the impact of risk perception on online purchase intention in e-commerce platforms. The data was gathered from 385 customers using e-commerce platforms. Moreover, this research adopted four frameworks from previous research to construct a new conceptual framework.
Findings – This research examined the factors that impact risk perception on online purchase intention in e-commerce platforms. The research's findings revealed that perceived CKM tool risk, social risk, product risk, and delivery risk of customers impact e-commerce platforms.
Research Limitations/Implications – There are many limitations to researching the factors influencing customer purchase intention on e-commerce platforms. This research is based in China and uses e-commerce platforms, so this study may not completely apply to people from different cultural backgrounds in other nations.
Originality/value - This research is about the important influencing variables that customers perceived CKM tool risk, social risk, product risk, delivery risk, and purchase intention.
The New Order Political Policy: The Prohibition of Literature Work by The Indonesian Government in 1966-1998
Authors: Sari Laila , Marjono Marjono , Sumardi Sumardi , Umamah Nurul , Surya Riza Afita 
Published: December 2022

Perwujudan nasional merupakan langkah utama yang dilakukan oleh Orde Baru pada masa pemerintahannya (1966-1998). Perwujudan budaya nasional di bidang kebudayaan dilakukan dengan karya sastra yang bertentangan dengan nasional. Tujuan dari penelitian ini adalah untuk mengetahui latar belakang, implementasi dan dampak dari kebijakan pelarangan karya sastra. Penelitian ini menggunakan metode penelitian sejarah dan pendekatan institusionalisme politik. Hasil penelitian menunjukkan bahwa latar belakang pelarangan karya sastra adalah munculnya resistensi kebijakan sastra. Implementasi kebijakan pelarangan karya sastra berupa pelarangan buku sastra dan tersingkirkan pengarang.
Kata Kunci : Orde Baru, Karya Sastra, Literasi.
EFFECTIVENESS E-HEALTH TO SELF MANAGEMENT OF DIABETES MELLITUS TYPE 2 : LITERATURE REVIEW
Authors: Hardiyanti Siti , Erindia Firnanda , Sigit Mulyono  , Achsan Tudhonny  , Umdatus Soleha  
Published: December 2022

Introduction: Patient and nurse is constructive relationship beneficial in a self-management support approach. Research shows e-health intervention has the potential to support self-management for adults with type 2 diabetes. The purpose this article to apply the application of e-health to people with type 2 diabetes mellitus.
Method: Method is search journal articles through basic data in ProQuest, Clinical key, EBSCO with a time span of 2018-2022, using the keywords "e-health intervention" and "diabetes mellitus type 2". The number of related articles is 10 journals.
Results: Results the literature review conducted showed that e-health has an effective and efficient impact on self-management in patients with type 2 diabetes mellitus, nurses can find time to find out the progress of people with diabetes mellitus, reduce the incidence of diabetes and complications.
Conclusion: Conclusion the use of e-health in self-management of people with diabetes mellitus has provided positive benefits for the development and improvement of service quality for the community. Health is a new medium in health services that requires broader knowledge and more in-depth practice, so the use of digital media in management needs to conduct further research in the focus of research on health.

Keywords: e-health, self-management, diabetes mellitus.
EFFICACY OF NAVIGATOR-TRIGGERED PACE TECHNIQUE MRCP IN CHOLEDOCHOLITHIASIS
Authors: BAYRAK Ahmet , TARHAN Çağla 
Published: December 2022

Aim: The navigator-triggered Prospective Acquisition Correction Enhancement technique is a method used to eliminate respiratory motion artifacts caused in magnetic resonance cholangiopancreatography examinations. The purpose of this study was to compare the diagnostic accuracy of navigator-triggered Prospective Acquisition Correction Enhancement tecnique magnetic resonance cholangiopancreatography examination with endoscopic retrograde cholangiopancreatography as a gold standard reference in presence of choledocholithiasis.
Materıal and Method: The diagnostic rates of magnetic resonance cholangiopancreatography examination performed with Prospective Acquisition Correction Enhancement technique in the diagnosis of choledocholithiasis were compared according to the results of the endoscopic retrograde cholangiopancreatography examination, which was accepted as a gold standard reference.
Results: Among 107 patients included in the study, 40 patients with magnetic resonance cholangiopancreatography and 36 patients with endoscopic retrograde cholangiopancreatography were diagnosed with choledocholithiasis. endoscopic retrograde cholangiopancreatography showed the presence of choledocholithiasis in 36 patients among 40 patients diagnosed as choledocholithiasis with magnetic resonance cholangiopancreatography. The positive predictivity value of the magnetic resonance cholangiopancreatography examination performed with the Prospective Acquisition Correction Enhancement technique was 90%, the negative predictivity value was 98.5%, the sensitivity was 97.3%, the specificity was 94.3%, and the diagnostic accuracy was 95.3%.
Conclusıon: We think that navigator-triggered magnetic resonance cholangiopancreatography examination obtained with Prospective Acquisition Correction Enhancement technique is a reliable method with high accuracy in the diagnosis of choledocholithiasis.
ANALISIS PROKSIMAT DAN SIFAT ORGANOLEPTIK “ONCOM MERAH ALTERNATIF” DAN “ONCOM HITAM ALTERNATIF”
Authors: Mulyani Sri , Wisma Restu Widyana 
Published: December 2022

<p>Oncom is a typical food of the people of West Java. So far there are two types of oncom known, namely red oncom and black oncom. Red oncom is generally made from tofu cake (soybean that has been taken protein in making tofu) with mold <em>Neurospora sitophila</em>. While black oncom is generally made from peanut cake which is sometimes mixed with tapioca flour with <em>Rhizopus oligosporus</em> tempeh mold. This research was conducted to utilize a mixture of tofu waste (ampas), tapioca waste (onggok) and peanut oil waste (bungkil) which is widely distributed in West Java to be processed into a type of oncom food so that it can be utilized. Because the raw material and composition used in this study are different from red oncom and black oncom in general, they are called "alternatif red oncom" and "alternatif black oncom". This study aims to analyze the proximate specifically the protein and fat content, as well as the organoleptic properties of "alternatif red oncom" and "alternatif black oncom". This study was conducted with experiments in the laboratory and the data were analyzed using descriptive statistical methods. The research was begun by making oncom from raw materials mixture of the tofu waste (ampas), onggok, and bungkil, then fermented with <em>N. sitophila</em> microbes for "alternatif red oncom" and <em>R. oligosporus</em> for "alternatif black oncom". After the oncoms were formed, the protein content was tested using the Kjeldahl method and fat content using the Soxhlet method. Organoleptic test of oncom products before and after being processed into food is carried out by the Hedonic test. The results showed that the protein content of "alternatif red oncom" (2.78 ± 0.05 %) is higher than "alternatif black oncom" (1.88 ± 0.05 %), and the fat content in "alternatif red oncom" (2.31 ± 0.05 %) is higher than "alternatif black oncom" (1.90 ± 0.05 %). The organoleptic test results showed that in terms of color, aroma, and texture "alternatif black oncom" tends to be preferred by panelists than "alternatif red oncom".</p><p> </p>