bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double faecal immunochemical testing in patients with symptoms suspicious of colorectal cancer
Authors: Gerrard A D , Maeda Y , Miller J , Gunn F , Theodoratou E , Noble C , Porteous L , Glancy S , MacLean P , Pattenden R , Dunlop M G , Din F V N ,   Edinburgh Colorectal Group, Clark A , Collie M , Collins D , Duff M , Goodbrand S , Mander J , Ventham N , Paterson H , Potter M , Reddy C , Speake D , Shaban F , Smith G , Vaughan-Shaw P 
Published: February 2023

Abstract

Background
Faecal immunochemical test (FIT)-directed pathways based on a single test have been implemented for symptomatic patients. However, with a single test, the sensitivity is 87 per cent at 10 µg haemoglobin (Hb) per g faeces. This aims of this study were to define the diagnostic performance of a single FIT, compared with double FIT in symptomatic populations.

Methods
Two sequential prospective patient cohorts referred with symptoms from primary care were studied. Patients in cohort 1 were sent a single FIT, and those in cohort 2 received two tests in succession before investigation. All patients were investigated, regardless of having a positive or negative test (threshold 10 µg Hb per g).

Results
In cohort 1, 2260 patients completed one FIT and investigation. The sensitivity of single FIT was 84.1 (95 per cent c.i. 73.3 to 91.8) per cent for colorectal cancer and 67.4 (61.0 to 73.4) per cent for significant bowel pathology. In cohort 2, 3426 patients completed at least one FIT, and 2637 completed both FITs and investigation. The sensitivity of double FIT was 96.6 (90.4 to 99.3) per cent for colorectal cancer and 83.0 (77.4 to 87.8) per cent for significant bowel pathology. The second FIT resulted in a 50.0 per cent reduction in cancers missed by the first FIT, and 30.0 per cent for significant bowel pathology. Correlation between faecal Hb level was only modest (rs = 0.58), and 16.8 per cent of double tests were discordant, 11.4 per cent in patients with colorectal cancer and 18.3 per cent in those with significant bowel pathology.

Conclusion
FIT in patients with high-risk symptoms twice in succession reduces missed significant colorectal pathology and has an acceptable workload impact.
Mohs micrographic surgery for the treatment of primary cutaneous mucinous carcinoma
Authors: Kelly Áine , Anand Rakesh , Natkunarajah Jana , Samarasinghe Venura , Craythorne Emma 
Published: February 2023

Abstract
Primary cutaneous mucinous carcinoma (PCMC) is a rare adnexal tumour of the skin. Clinically, it appears as a benign cyst, but it has characteristic histopathology. It is a slow-growing tumour that rarely metastasizes but is associated with significant morbidity due to its high recurrence rate. Standard practice has been to surgically remove it with a wide local excision of 1–2-cm margin. In the last decade, increasing reports of Mohs micrographic surgery (MMS) for the treatment of PCMC have been described. MMS appears to reduce recurrence rates while allowing for more conservative margins. Given the rarity of PCMC, there are no prospective randomized control trials on treatment. This is the largest case series of PCMC treated by MMS to date.
Skin surgery training: a literature review of methods and their efficacy
Authors: Passby Lauren , Tso Simon , Wernham Aaron 
Published: February 2023

Abstract
Skin surgery ranges from small biopsies to Mohs micrographic surgery and excisions necessitating complex skin flap design or grafting. For all dermatology doctors in training there is a need to acquire competence to perform skin surgery safely, in an appropriate timeframe and with minimal complication rates. There exist a range of different methods, with varying reliance upon advancing technology, to teach skin surgery and to refine surgical skills before procedures are performed on patients. We searched PubMed, MEDLINE and SCOPUS databases to identify all papers relevant to postgraduate dermatology skin surgery teaching and training published in the past 10 years in English (see Appendix S1 in the Supporting Information for our search strategy). This yielded 440 results, for which all abstracts were screened. Manuscripts related to aesthetic surgery training, such as robotic hair transplantation training are excluded.
Long-Term Within- and Between-Subject Biological Variation Data of Hematological Parameters in Recreational Endurance Athletes
Authors: Diaz-Garzon Jorge , Fernandez–Calle Pilar , Aarsand Aasne K , Sandberg Sverre , Coskun Abdurrahman , Equey Tristan , Aikin Reid , Buno Soto Antonio 
Published: February 2023

Abstract

Background
Hematological parameters have many applications in athletes, from monitoring health to uncovering blood doping. This study aimed to deliver biological variation (BV) estimates for 9 hematological parameters by a Biological Variation Data Critical Appraisal Checklist (BIVAC) design in a population of recreational endurance athletes and to assess the effect of self-reported exercise and health-related variables on BV.

Methods
Samples were drawn from 30 triathletes monthly for 11 months and measured in duplicate for hematological measurands on an Advia 2120 analyzer (Siemens Healthineers). After outlier and homogeneity analysis, within-subject (CVI) and between-subject (CVG) BV estimates were delivered (CV-ANOVA and log-ANOVA, respectively) and a linear mixed model was applied to analyze the effect of exercise and other related variables on the BV estimates.

Results
CVI estimates ranged from 1.3% (95%CI, 1.2-1.4) for mean corpuscular volume to 23.8% (95%CI, 21.6-26.3) for reticulocytes. Sex differences were observed for platelets and OFF-score. The CVI estimates were higher than those reported for the general population based on meta-analysis of eligible studies in the European Biological Variation Database, but 95%CI overlapped, except for reticulocytes, 23.9% (95%CI, 21.6-26.5) and 9.7% (95%CI, 6.4-11.0), respectively. Factors related to exercise and athletes’ state of health did not appear to influence the BV estimates.

Conclusions
This is the first BIVAC-compliant study delivering BV estimates that can be applied to athlete populations performing high-level aerobic exercise. CVI estimates of most parameters were similar to the general population and were not influenced by exercise or athletes’ state of health.
Defining Relevant Markets in the Digital Era: Lessons from Merger Control in Brazil, Chile and Mexico
Authors: Canales Maria Paz , De Souza Michel Roberto , Da Motta Lucas Griebeler 
Published: February 2023

Abstract
Relevant market definition methodology has been a thorny issue over the years for antitrust doctrine and practice. This is especially true when it comes to digital markets, in which prices may not be a significant variable for defining relevant markets. Traditional or static views of competition may result in improper market definitions, which might result in the clearance of mergers in digital markets because antitrust authorities define market shares according to traditional methods of measurement. However, this seems like a chicken-and-egg problem, because it is only by appropriately defining relevant markets that it is possible to establish if market shares are high or low. This article discusses practical implications for antitrust enforcement derived from the relevant market definitions adopted in high-profile digital market mergers in Brazil, Chile and Mexico. Many of these cases have elements of conglomerate or vertical integration that go beyond traditional demand substitution measurement and test the authorities’ ability to foresee future competitive scenarios in which digital competition and brick-and-mortar competition have become increasingly complementary. These cases also show an increasingly large role of data concentration as a driver in the attractiveness of the acquisitions.
Multiple-model GWAS identifies optimal allelic combinations of quantitative trait loci for malic acid in tomato
Authors: Gai Wenxian , Yang Fan , Yuan Liangdan , ul Haq Saeed , Wang Yaru , Wang Ying , Shang Lele , Li Fangman , Ge Pingfei , Dong Haiqiang , Tao Jinbao , Wang Fei , Zhang Xingyu , Zhang Yuyang 
Published: February 2023

AbstractMalic acid (MA) is an important flavor acid in fruits and acts as a mediator in a series of metabolic pathways. It is important to understand the factors affecting MA metabolism for fruit flavor improvement and to understand MA-mediated biological processes. However, the metabolic accumulation of MA is controlled by complex heredity and environmental factors, making it difficult to predict and regulate the metabolism of MA. In this study, we carried out a genome-wide association study (GWAS) on MA using eight milestone models with two-environment repeats. A series of associated SNP variations were identified from the GWAS, and 15 high-confidence annotated genes were further predicted based on linkage disequilibrium and lead SNPs. The transcriptome data of candidate genes were explored within different tomato organs as well as various fruit tissues, and suggested specific expression patterns in fruit pericarp. Based on the genetic parameters of population differentiation and SNP distribution, tomato MA content has been more influenced by domestication sweeps and less affected by improvement sweeps in the long-term history of tomato breeding. In addition, genotype × environment interaction might contribute to the difference in domestication phenotypic data under different environments. This study provides new genetic insights into how tomato changed its MA content during breeding and makes available function-based markers for breeding by marker-assisted selection.
Integrating economics into fisheries science and advice: progress, needs, and future opportunities
Authors: Thébaud O , Nielsen J R , Motova A , Curtis H , Bastardie F , Blomqvist G E , Daurès F , Goti L , Holzer J , Innes J , Muench A , Murillas A , Nielsen R , Rosa R , Thunberg E , Villasante S , Virtanen J , Waldo S , Agnarsson S , Castilla Espino D , Curtin R , DePiper G , Doering R , Ellefsen H , García del Hoyo1 J J , Gourguet S , Greene P , Hamon K G , Haynie A , Kellner J B , Kuikka S , Le Gallic B , Macher C , Prellezo R , Santiago Castro-Rial J , Sys K , van Oostenbrugge H , Vastenhoud B M J 
Published: February 2023

Abstract
While the science supporting fisheries management has generally been dominated by the natural sciences, there has been a growing recognition that managing fisheries essentially means managing economic systems. Indeed, over the past seven decades, economic ideas and insights have increasingly come to play a role in fisheries management and policy. As an illustration of this, the International Council for the Exploration of the Sea (ICES) has been actively seeking to expand the scope of its scientific expertise beyond natural sciences [another inter-governmental marine science organization which has done this over the same period is the North Pacific Marine Science organization (PICES)]. In particular, the recently created ICES Working Group on Economics set out to review current work and key future needs relating to economic research and management advice on marine capture fisheries. This article presents the results of this review and addresses how economic research can be incorporated into the science of ICES to provide integrated perspectives on fisheries systems that can contribute to the provision of advice in support of policy development and management decision-making for sustainable uses of living marine resources.
Generalized Permutahedra and Positive Flag Dressians
Authors: Joswig Michael , Loho Georg , Luber Dante , Alberto Olarte Jorge 
Published: February 2023

Abstract
We study valuated matroids, their tropical incidence relations, flag matroids, and total positivity. This leads to a characterization of permutahedral subdivisions, namely subdivisions of regular permutahedra into generalized permutahedra. Further, we get a characterization of those subdivisions arising from positive valuated flag matroids.
Adjunctive controlled intrusion of the maxillary first molar using orthodontic miniscrews
Authors: Marya Anand , Winoto Ervina Restiwulan 
Published: February 2023

AbstractIn the absence of the mandibular first molar, there is corresponding supra-eruption of the maxillary first molar, which can lead to occlusal interferences compromising the space available for restoration with a prosthesis. In this case report, the maxillary left first molar intrusion has been discussed with the use of two miniscrews. A 28-year-old female reported with a missing mandibular left first molar and wanting to replace it with a dental implant. The patient presented with a Class I skeletal relation, mild proclination of the anteriors and occlusal contacts. The maxillary first molar had erupted by &gt;4 mm beyond the occlusal plane, thereby reducing the space available for placement of a lower prosthetic crown. After 5 months of intrusion, the desired occlusal clearance was achieved, and impressions were recorded. For retention, the patient was given an upper clear vacuum retainer and the crown was placed on the implant.
Two cases of interparietal inguinal hernias undergoing laparoscopic treatment: a case series
Authors: Ozawa Hiroki , Hara Asuka , Hayashi Keita , Kaneko Yasushi , Kikuchi Hiroto , Fujisaki Hiroto , Hirata Akira , Hongo Kumiko , Takano Kiminori , Suga Atsushi , Yo Kikuo , Yoneyama Kimiyasu , Nakagawa Motohito 
Published: February 2023

AbstractInterparietal inguinal hernia, an exceedingly rare type of inguinal hernia in which the hernia sac anatomically lies between the tissue layers of the abdominal wall, is difficult to diagnose from physical findings. Given the few reports on interparietal inguinal hernias, this condition has remained fairly unrecognized. Herein, we report the successful imaging and laparoscopic diagnoses as well as repair of an interparietal inguinal hernia. Atypical physical findings and computed tomography data help in the diagnosis of an interparietal inguinal hernia. The laparoscopic approach is useful and feasible for both the diagnosis and treatment of interparietal inguinal hernia.
The morphing of dictators: why dictators get worse over time
Authors: Basu Kaushik 
Published: February 2023

Abstract
Dictators, even those who seize power with the intention of helping the nation, frequently morph over time into tyrants. There may be many reasons for this. This paper focuses on one interesting and arguably pervasive driver behind this process. A model is developed which shows that the series of decisions taken over time by an authoritarian leader concerning how much political intrigue and evil to indulge in in order to stay in power leads to a dynamic inconsistency converting the leader into a tyrant. It is possible that the dictator will, eventually, come to regret this, but by then they have no exit options. The analysis prompts us to think about ex ante rules and term-limit provisions to prevent this from happening.
PHYTOCHROME INTERACTING FACTOR 4 regulates microtubule organization to mediate high temperature-induced hypocotyl elongation in Arabidopsis
Authors: Zhou Dingding , Wang Xiaohong , Wang Xiangfeng , Mao Tonglin 
Published: February 2023

Abstract
Hypocotyl elongation is an important morphological response during plant thermomorphogenesis. Multiple studies indicate that the transcription factor PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) is a key regulator of high temperature-induced hypocotyl elongation. However, the underlying cellular mechanisms regarding PIF4-mediated hypocotyl elongation are largely unclear. In this study, we found that PIF4 regulates the PLANT U-BOX TYPE E3 UBIQUITIN LIGASE 31 (PUB31)–SPIRAL1 (SPR1) module and alters cortical microtubule reorganization to promote hypocotyl cell elongation during Arabidopsis thaliana (Arabidopsis) thermomorphogenesis. SPR1 loss-of-function mutants exhibit much shorter hypocotyls when grown at 28 °C, indicating a positive role for SPR1 in high ambient temperature-induced hypocotyl elongation. High ambient temperature induces SPR1 expression in a PIF4-dependent manner, and stabilizes SPR1 protein to mediate microtubule reorganization. Further investigation showed that PUB31 interacts with and ubiquitinates SPR1. In particular, the ubiquitinated effect on SPR1 was moderately decreased at high temperature, which was due to the direct binding of PIF4 to the PUB31 promoter and down-regulating its expression. Thus, this study reveals a mechanism in which PIF4 induces SPR1 expression and suppresses PUB31 expression, resulting in the accumulation and stabilization of SPR1 protein, and further promoting hypocotyl cell elongation by altering cortical microtubule organization during Arabidopsis thermomorphogenesis.
Soybean ZINC FINGER PROTEIN03 targets two SUPEROXIDE DISMUTASE1s and confers resistance to Phytophthora sojae
Authors: Li Wei , Zheng Xiang , Cheng Rong , Zhong Chanjuan , Zhao Jie , Liu Tyler H , Yi Tuyong , Zhu Zhendong , Xu Jieting , Meksem Khalid , Dai Liangying , Liu Shiming 
Published: February 2023

Abstract
Phytophthora sojae causes Phytophthora root and stem rot disease of soybean (Glycine max), leading to huge annual yield loss worldwide, but resistance to Phytophthora sojae (Rps) genes remains elusive. Soybean cultivar “Yudou 29” is resistant to P. sojae strain PsMC1, and this study aimed to clone, identify, and characterize the Rps gene in Yudou 29 (RpsYD29) and clarify its functional mechanism. We map-based cloned RpsYD29 (ZINC FINGER PROTEIN03, GmZFP03) using the families of a cross between Yudou 29 and a P. sojae-susceptible soybean cultivar “Jikedou 2”. P. sojae resistance of GmZFP03 was functionally validated by stable soybean genetic transformation and allele-phenotype association analysis. GmZFP03 was identified as a C2H2-type zinc finger protein transcription factor, showing 4 amino acid residue polymorphisms (V79F, G122-, G123-, and D125V) and remarkably different expression patterns between resistant and susceptible soybeans. Notably boosted activity and gene expression of superoxide dismutase (SOD) in resistant-type GmZFP03-expressed transgenic soybean, substantial enhancement of P. sojae resistance of wild-type soybean by exogenous SOD treatment, and GmZFP03 binding to and activation of 2 SOD1 (Glyma.03g242900 and Glyma.19g240400) promoters demonstrated the involvement of SOD1s in GmZFP03-mediated resistance to P. sojae strain PsMC1. Thus, this study cloned the soybean P. sojae-resistant GmZFP03, the product of which specifically targets 2 SOD1 promoters. GmZFP03 can be directly used for precise P. sojae-resistance soybean breeding.
Computed tomography for malignancy screening in patients with rheumatoid arthritis before initiation of disease modifying antirheumatic drug
Authors: Miyata Hiroko , Sonomoto Koshiro , Fukuyo Shunsuke , Nakayamada Shingo , Nakano Kazuhisa , Iwata Shigeru , Miyazaki Yusuke , Kawabe Akio , Aoki Takatoshi , Tanaka Yoshiya 
Published: February 2023

Abstract

Objectives
This study aimed to clarify the usefulness of screening for malignancies using CT before the initiation of biologic and targeted synthetic DMARDs (b/tsDMARDs) in patients with active RA.

Methods
We examined 2192 patients with RA who underwent plain CT scans prior to the initiation of b/tsDMARDs. The sensitivity for detecting malignancy was measured and compared with that of regular screening (physical examination and X-ray). We then evaluated the clinical characteristics, prognosis and treatment of patients with RA with concomitant malignancies. Additionally, we determined the incidence rate of malignancy in patients with RA who were initiated on b/tsDMARDs after CT screening.

Results
Of the 2192 patients, 33 (1.5%) were diagnosed with malignancy after CT screening. Whereas regular screening detected only seven malignancies, CT screening further detected 26 (including 19 at the early stage). On the other hand, 86% of the malignancies detectable by regular screening were at an advanced stage. Patients diagnosed with early-stage malignancies received RA treatments that included b/tsDMARDs after curative resection; 80% of these patients achieved low disease activity after 1 year. This rate was comparable to the patients without malignancy detection after screening (70%). The 5 year incidence of malignancy after the initiation of b/tsDMARDs after CT screening was lower than that of the RA cohort without CT screening (standardized incidence ratio: 0.35).

Conclusion
Screening in patients with RA using CT before the initiation of b/tsDMARDs allows for the early detection and treatment of malignancy, resulting in safer and more stable b/tsDMARD treatments.
How Christian Nurses Respond to Patient Requests for Prayer
Authors: Mamier Iris , Park Carla Gober , Taylor Elizabeth Johnston 
Published: February 2023

ABSTRACT:
Nurse-provided spiritual care includes support of patient spiritual practices such as prayer. However, limited evidence exists about how nurses respond when a patient requests prayer. A subsample of nurses (n = 381) from a larger study responded to two open-ended questions in an online survey in response to a prayer scenario. Among these mostly Christian nurses, 97% indicated willingness to pray. Content analysis revealed a five-component structure for praying: Open, Set the Stage, Request, Wrap-up, Close. The structure provides a template for future research and nurse prayer in clinical contexts.
Using Nursing Interventions Classifications to Document Faith Community Nursing Transitional Care
Authors: Ziebarth Deborah J. , Campbell Katora , Ahn SangNam , Williams Janice , Lane Myron 
Published: February 2023

ABSTRACT:
One out of five Medicare beneficiaries is readmitted within 30 days after hospital discharge, and as many as three in four readmissions are preventable. This study describes transitional care interventions (TCIs) delivered by one faith community nurse (FCN) to at-risk seniors living in a certain ZIP code. Two years of nursing documentation (2,280 interventions) were translated into Nursing Interventions Classification standardized nursing language. Results indicate the FCN provided priority TCIs including spiritual care. In fully describing TCIs using a nursing language, results support that the FCN transitional care model is a method worth exploring to provide wholistic transitional care.