bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between maternal hyperglycemia in pregnancy and offspring anthropometry in early childhood: the pandora wave 1 study
Authors: Titmuss Angela , Barzi Federica , Barr Elizabeth L. M. , Webster Vanya , Wood Anna , Kelaart Joanna , Kirkwood Marie , Connors Christine , Boyle Jacqueline A. , Moore Elizabeth , Oats Jeremy , McIntyre H. David , Zimmet Paul , Brown Alex D. H. , Shaw Jonathan E. , Craig Maria E. , Maple-Brown Louise J. 
Published: August 2023

Abstract
Background
In-utero hyperglycemia exposure influences later cardiometabolic risk, although few studies include women with pre-existing type 2 diabetes (T2D) or assess maternal body mass index (BMI) as a potential confounder.

Objective
To explore the association of maternal T2D and gestational diabetes mellitus (GDM) with childhood anthropometry, and the influence of maternal BMI on these associations.

Methods
The PANDORA cohort comprises women (n = 1138) and children (n = 1163). Women with GDM and T2D were recruited from a hyperglycemia in pregnancy register, and women with normoglycemia from the community. Wave 1 follow-up included 423 children, aged 1.5–5 years (median follow-up age 2.5 years). Multivariable linear regression assessed associations between maternal antenatal variables, including BMI and glycemic status, with offspring anthropometry (weight, height, BMI, skinfold thicknesses, waist, arm and head circumferences).

Results
Greater maternal antenatal BMI was associated with increased anthropometric measures in offspring independent of maternal glycemic status. After adjustment, including for maternal BMI, children exposed to maternal GDM had lower mean weight (−0.54 kg, 95% CI: −0.99, −0.11), BMI (−0.55 kg/m2, 95% CI: −0.91, −0.20), head (−0.52 cm, 95% CI: −0.88, −0.16) and mid-upper arm (−0.32 cm, 95% CI: −0.63, −0.01) circumferences, and greater mean suprailiac skinfold (0.78 mm, 95% CI: 0.13, 1.43), compared to children exposed to normoglycemia. Adjustment for maternal BMI strengthened the negative association between GDM and child weight, BMI and circumferences. Children exposed to maternal T2D had smaller mean head circumference (−0.82 cm, 95% CI: −1.33, −0.31) than children exposed to normoglycemia. Maternal T2D was no longer associated with greater child mean skinfolds (p = 0.14) or waist circumference (p = 0.18) after adjustment for maternal BMI.

Conclusions
Children exposed to GDM had greater suprailiac skinfold thickness than unexposed children, despite having lower mean weight, BMI and mid-upper arm circumference, and both GDM and T2D were associated with smaller mean head circumference. Future research should assess whether childhood anthropometric differences influence lifetime cardiometabolic and neurodevelopmental risk.
Intense ultraviolet–visible–infrared full-spectrum laser
Authors: Hong Lihong , Liu Liqiang , Liu Yuanyuan , Qian Junyu , Feng Renyu , Li Wenkai , Li Yanyan , Peng Yujie , Leng Yuxin , Li Ruxin , Li Zhi-Yuan 
Published: August 2023

AbstractA high-brightness ultrabroadband supercontinuum white laser is desirable for various fields of modern science. Here, we present an intense ultraviolet-visible-infrared full-spectrum femtosecond laser source (with 300–5000 nm 25 dB bandwidth) with 0.54 mJ per pulse. The laser is obtained by sending a 3.9 μm, 3.3 mJ mid-infrared pump pulse into a cascaded architecture of gas-filled hollow-core fiber, a bare lithium niobate crystal plate, and a specially designed chirped periodically poled lithium niobate crystal, under the synergic action of second and third order nonlinearities such as high harmonic generation and self-phase modulation. This full-spectrum femtosecond laser source can provide a revolutionary tool for optical spectroscopy and find potential applications in physics, chemistry, biology, material science, industrial processing, and environment monitoring.
Dissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk
Authors: Zhou Xuan , Xiao Qian , Jiang Fangyuan , Sun Jing , Wang Lijuan , Yu Lili , Zhou Yajing , Zhao Jianhui , Zhang Han , Yuan Shuai , Timofeeva Maria , Spiliopoulou Athina , Mesa-Eguiagaray Ines , Farrington Susan M. , Law Philip J. , Houlston Richard S. , Ding Kefeng , Dunlop Malcolm G. , Theodoratou Evropi , Li Xue 
Published: August 2023

Abstract
Background
Tobacco smoking is suggested as a risk factor for colorectal cancer (CRC), but the complex relationship and the potential pathway are not fully understood.

Methods
We performed two-sample Mendelian randomisation (MR) analyses with genetic instruments for smoking behaviours and related DNA methylation in blood and summary-level GWAS data of colorectal cancer to disentangle the relationship. Colocalization analyses and prospective gene-environment interaction analyses were also conducted as replication.

Results
Convincing evidence was identified for the pathogenic effect of smoking initiation on CRC risk and suggestive evidence was observed for the protective effect of smoking cessation in the univariable MR analyses. Multivariable MR analysis revealed that these associations were independent of other smoking phenotypes and alcohol drinking. Genetically predicted methylation at CpG site cg17823346 [ZMIZ1] were identified to decrease CRC risk; while genetically predicted methylation at cg02149899 would increase CRC risk. Colocalization and gene-environment interaction analyses added further evidence to the relationship between epigenetic modification at cg17823346 [ZMIZ1] as well as cg02149899 and CRC risk.

Discussion
Our study confirms the significant association between tobacco smoking, DNA methylation and CRC risk and yields a novel insight into the pathogenic effect of tobacco smoking on CRC risk.
A cell cycle centric view of tumour dormancy
Authors: Weston William A. , Barr Alexis R. 
Published: August 2023

AbstractTumour dormancy and recurrent metastatic cancer remain the greatest clinical challenge for cancer patients. Dormant tumour cells can evade treatment and detection, while retaining proliferative potential, often for years, before relapsing to tumour outgrowth. Cellular quiescence is one mechanism that promotes and maintains tumour dormancy due to its central role in reducing proliferation, elevating cyto-protective mechanisms, and retaining proliferative potential. Quiescence/proliferation decisions are dictated by intrinsic and extrinsic signals, which regulate the activity of cyclin-dependent kinases (CDKs) to modulate cell cycle gene expression. By clarifying the pathways regulating CDK activity and the signals which activate them, we can better understand how cancer cells enter, maintain, and escape from quiescence throughout the progression of dormancy and metastatic disease. Here we review how CDK activity is regulated to modulate cellular quiescence in the context of tumour dormancy and highlight the therapeutic challenges and opportunities it presents.
Leigh-like syndrome with progressive cerebellar atrophy caused by novel HIBCH variants
Authors: Taura Yoshihiro , Tozawa Takenori , Isoda Kenichi , Hirai Satori , Chiyonobu Tomohiro , Yano Naoko , Hayashi Takahiro , Yoshida Takeshi , Iehara Tomoko 
Published: August 2023

AbstractPathogenic variants in theHIBCHgene cause HIBCH deficiency, leading to mitochondrial disorders associated with valine metabolism. Patients typically present with symptoms such as developmental regression/delay, encephalopathy, hypotonia and dystonia. Brain magnetic resonance imaging (MRI) shows bilateral lesions in the basal ganglia with/without brainstem involvement. Here, we report a case of a Japanese patient with Leigh-like syndrome caused by novelHIBCHvariants. Long-term follow-up MRI revealed progressive cerebellar atrophy, which expands the phenotypic spectrum of HIBCH deficiency.
Dynamic light filtering over dermal opsin as a sensory feedback system in fish color change
Authors: Schweikert Lorian E. , Bagge Laura E. , Naughton Lydia F. , Bolin Jacob R. , Wheeler Benjamin R. , Grace Michael S. , Bracken-Grissom Heather D. , Johnsen Sönke 
Published: August 2023

AbstractDynamic color change has evolved multiple times, with a physiological basis that has been repeatedly linked to dermal photoreception via the study of excised skin preparations. Despite the widespread prevalence of dermal photoreception, both its physiology and its function in regulating color change remain poorly understood. By examining the morphology, physiology, and optics of dermal photoreception in hogfish (Lachnolaimus maximus), we describe a cellular mechanism in which chromatophore pigment activity (i.e., dispersion and aggregation) alters the transmitted light striking SWS1 receptors in the skin. When dispersed, chromatophore pigment selectively absorbs the short-wavelength light required to activate the skin’s SWS1 opsin, which we localized to a morphologically specialized population of putative dermal photoreceptors. As SWS1 is nested beneath chromatophores and thus subject to light changes from pigment activity, one possible function of dermal photoreception in hogfish is to monitor chromatophores to detect information about color change performance. This framework of sensory feedback provides insight into the significance of dermal photoreception among color-changing animals.
Emergent increase in coral thermal tolerance reduces mass bleaching under climate change
Authors: Lachs Liam , Donner Simon D. , Mumby Peter J. , Bythell John C. , Humanes Adriana , East Holly K. , Guest James R. 
Published: August 2023

AbstractRecurrent mass bleaching events threaten the future of coral reefs. To persist under climate change, corals will need to endure progressively more intense and frequent marine heatwaves, yet it remains unknown whether their thermal tolerance can keep pace with warming. Here, we reveal an emergent increase in the thermal tolerance of coral assemblages at a rate of 0.1 °C/decade for a remote Pacific coral reef system. This led to less severe bleaching impacts than would have been predicted otherwise, indicating adaptation, acclimatisation or shifts in community structure. Using future climate projections, we show that if thermal tolerance continues to rise over the coming century at the most-likely historic rate, substantial reductions in bleaching trajectories are possible. High-frequency bleaching can be fully mitigated at some reefs under low-to-middle emissions scenarios, yet can only be delayed under high emissions scenarios. Collectively, our results indicate a potential ecological resilience to climate change, but still highlight the need for reducing carbon emissions in line with Paris Agreement commitments to preserve coral reefs.
Efficient and selective capture of thorium ions by a covalent organic framework
Authors: Liu Xiaojuan , Gao Feng , Jin Tiantian , Ma Ke , Shi Haijiang , Wang Ming , Gao Yanan , Xue Wenjuan , Zhao Jing , Xiao Songtao , Ouyang Yinggen , Ye Guoan 
Published: August 2023

AbstractThe selective separation of thorium from rare earth elements and uranium is a critical part of the development and application of thorium nuclear energy in the future. To better understand the role of different N sites on the selective capture of Th(IV), we design an ionic COF named Py-TFImI-25 COF and its deionization analog named Py-TFIm-25 COF, both of which exhibit record-high separation factors ranging from 102to 105. Py-TFIm-25 COF exhibits a significantly higher Th(IV) uptake capacity and adsorption rate than Py-TFImI-25 COF, which also outperforms the majority of previously reported adsorbents. The selective capture of Py-TFImI-25 COF and Py-TFIm-25 COF on thorium is via Th-N coordination interaction. The prioritization of Th(IV) binding at different N sites and the mechanism of selective coordination are then investigated. This work provides an in-depth insight into the relationship between structure and performance, which can provide positive feedback on the design of novel adsorbents for this field.
Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy
Authors: Li Lin , Zhang Mengxing , Li Jing , Liu Tiantian , Bao Qixue , Li Xi , Long Jiaying , Fu Leyao , Zhang Zhirong , Huang Shiqi , Liu Zhenmi , Zhang Ling 
Published: August 2023

AbstractBiological membranes often play important functional roles in biomimetic drug delivery systems. We discover that the circulation time and targeting capability of biological membrane coated nanovehicles can be significantly improved by reducing cholesterol level in the coating membrane. A proof-of-concept system using cholesterol-reduced and PD-1-overexpressed T cell membrane to deliver a photothermal agent and a STING agonist is thus fabricated. Comparing with normal membrane, this engineered membrane increases tumor accumulation by ~2-fold. In a melanoma model in male mice, tumors are eliminated with no recurrence in >80% mice after intravenous injection and laser irradiation; while in a colon cancer model in male mice, ~40% mice are cured without laser irradiation. Data suggest that the engineered membranes escape immune surveillance to avoid blood clearance while keeping functional surface molecules exposed. In summary, we develop a simple, effective, safe and widely-applicable biological membrane modification strategy. This “subtractive” strategy displays some advantages and is worth further development.
Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair
Authors: Parisis Nikolaos , Dans Pablo D. , Jbara Muhammad , Singh Balveer , Schausi-Tiffoche Diane , Molina-Serrano Diego , Brun-Heath Isabelle , Hendrychová Denisa , Maity Suman Kumar , Buitrago Diana , Lema Rafael , Nait Achour Thiziri , Giunta Simona , Girardot Michael , Talarek Nicolas , Rofidal Valérie , Danezi Katerina , Coudreuse Damien , Prioleau Marie-Noëlle , Feil Robert , Orozco Modesto , Brik Ashraf , Wu Pei-Yun Jenny , Krasinska Liliana , Fisher Daniel 
Published: August 2023

AbstractHistone post-translational modifications promote a chromatin environment that controls transcription, DNA replication and repair, but surprisingly few phosphorylations have been documented. We report the discovery of histone H3 serine-57 phosphorylation (H3S57ph) and show that it is implicated in different DNA repair pathways from fungi to vertebrates. We identified CHK1 as a major human H3S57 kinase, and disrupting or constitutively mimicking H3S57ph had opposing effects on rate of recovery from replication stress, 53BP1 chromatin binding, and dependency on RAD52. In fission yeast, mutation of all H3 alleles to S57A abrogated DNA repair by both non-homologous end-joining and homologous recombination, while cells with phospho-mimicking S57D alleles were partly compromised for both repair pathways, presented aberrant Rad52 foci and were strongly sensitised to replication stress. Mechanistically, H3S57ph loosens DNA-histone contacts, increasing nucleosome mobility, and interacts with H3K56. Our results suggest that dynamic phosphorylation of H3S57 is required for DNA repair and recovery from replication stress, opening avenues for investigating the role of this modification in other DNA-related processes.
Transparent dynamic infrared emissivity regulators
Authors: Jia Yan , Liu Dongqing , Chen Desui , Jin Yizheng , Chen Chen , Tao Jundong , Cheng Haifeng , Zhou Shen , Cheng Baizhang , Wang Xinfei , Meng Zhen , Liu Tianwen 
Published: August 2023

AbstractDynamic infrared emissivity regulators, which can efficiently modulate infrared radiation beyond vision, have emerged as an attractive technology in the energy and information fields. The realization of the independent modulation of visible and infrared spectra is a challenging and important task for the application of dynamic infrared emissivity regulators in the fields of smart thermal management and multispectral camouflage. Here, we demonstrate an electrically controlled infrared emissivity regulator that can achieve independent modulation of the infrared emissivity while maintaining a high visible transparency (84.7% at 400–760 nm). The regulators show high degree of emissivity regulation (0.51 at 3–5 μm, 0.41 at 7.5–13 μm), fast response ( < 600 ms), and long cycle life ( > 104 cycles). The infrared emissivity regulation is attributed to the modification of the carrier concentration in the surface depletion layer of aluminum-doped zinc oxide nanocrystals. This transparent infrared emissivity regulator provides opportunities for applications such as on-demand smart thermal management, multispectral displays, and adaptive camouflage.
Evaporation-induced hydrodynamics control plasmid transfer during surface-associated microbial growth
Authors: Ruan Chujin , Borer Benedict , Ramoneda Josep , Wang Gang , Johnson David R. 
Published: August 2023

AbstractDroplet evaporation is a general process in unsaturated environments that results in micro-scale hydrodynamic flows which in turn determine the spatial distributions of microbial cells across surfaces. These spatial distributions can have significant effects on the development and functioning of surface-associated microbial communities, with consequences for important processes such as the spread of plasmids. Here, we experimentally quantified how evaporation-induced hydrodynamic processes modulate the initial deposition patterns of microbial cells (via the coffee ring effect and Marangoni convection) and how these patterns control the spread of an antibiotic resistance-encoding plasmid during surface-associated growth. We found that plasmid spread is a function of the initial density of cells deposited along the droplet periphery, which is a manifestation of the coffee ring effect. Using an individual-based model, we systematically linked how the different initial cell deposition patterns caused by the relative strengths of the coffee ring effect and Marangoni convection determine the extent of plasmid transfer during surface-associated growth. Our study demonstrates that evaporation-induced hydrodynamic processes that are common in nature can alter crucial ecological properties of surface-associated microbial communities and control the proliferation of plasmids, with consequences on the spread of antibiotic resistance and other plasmid-encoded traits.
Visualizing oxygen transport pathways during intergranular oxidation in Ni-Cr
Authors: Weiser Martin , Olszta Matthew J. , Engelhard Mark H. , Zhu Zihua , Schreiber Daniel K. 
Published: August 2023

AbstractThe transport paths of O during intergranular oxidation in binary Ni-Cr were investigated. To isolate the selective oxidation of Cr, oxidation was performed with a CO/CO2 gas mixture in which the oxygen partial pressure was kept under the NiO dissociation pressure. A combination of electron microscopy and atom probe tomography (APT) was used to study the nanometer-scale details of the passivation and penetrative intergranular oxidation processes at high-energy grain boundaries. Oxygen transport towards the terminating oxidation front is elucidated with dedicated usage of oxygen tracer exchange experiments. Secondary ion mass spectroscopy and APT support classical theories of internal oxidation, revealing preferred transport paths at the oxide/alloy interface with sub-nanometer resolution.
Standardizing practices and flux predictions in membrane science via simplified equations and membrane characterization
Authors: Tiraferri Alberto , Malaguti Marco , Mohamed Madina , Giagnorio Mattia , Aschmoneit Fynn Jerome 
Published: August 2023

AbstractThe development of membranes and membrane-based separation processes should be accompanied by a standardization of the protocols applied for membrane characterization and for data analysis. Here, streamlined equations for the estimation of the water flux and of the observed salt permeability coefficient in pressure-driven processes deploying dense membranes are presented. Also, a protocol for the experimental characterization of the transport properties of dense membranes is presented and the results are validated against the proposed equations. The proposed water flux equation is algebraic, whereas the ordinary equation needs to be solved iteratively. Moreover, in contrast to the traditional expression for the solute transport coefficient, which requires estimation of the concentration polarization, the respective equation proposed in this study only requires bulk parameters. Dimensionless variables for water flux, driving pressure, and mass transfer are introduced, and a filtration efficiency is defined, a useful parameter in terms of process design.
Spatial and Temporal Availability of Cloud-free Optical Observations in the Tropics to Monitor Deforestation
Authors: Flores-Anderson Africa I. , Cardille Jeffrey , Azad Khashayar , Cherrington Emil , Zhang Yingtong , Wilson Sylvia 
Published: August 2023

AbstractState-of-the-art methodologies to monitor deforestation rely mostly on optical satellite observations. High-density optical time series can enable the detection of deforestation almost as soon as it occurs. However, deforestation monitoring in the tropics can be hindered by high cloud coverage, and thus the responsiveness of managers, enforcement agencies, and scientists. To understand the implications of cloud contamination in freely available optical data we analyzed combined time series from Landsat 7, 8, and Sentinel-2 over the tropics from 2017–2021. Datasets derived for each 30 m × 30 m of the 59.4 M km2 domain include a) number of cloud-free observations per year, b) maximum consecutive days without clear imagery within a year, and c) final date of the longest waiting period. The datasets reflect where and when data gaps in optical time series exist due to cloud contamination. Scripts to access and extend the datasets are shared and documented. The datasets can be used to prioritize areas where complementary observations, such as radar imagery, are needed for implementing effective deforestation alert systems.
A magnetoencephalography dataset during three-dimensional reaching movements for brain-computer interfaces
Authors: Yeom Hong Gi , Kim June Sic , Chung Chun Kee 
Published: August 2023

AbstractStudying the motor-control mechanisms of the brain is critical in academia and also has practical implications because techniques such as brain-computer interfaces (BCIs) can be developed based on brain mechanisms. Magnetoencephalography (MEG) signals have the highest spatial resolution (~3 mm) and temporal resolution (~1 ms) among the non-invasive methods. Therefore, the MEG is an excellent modality for investigating brain mechanisms. However, publicly available MEG data remains scarce due to expensive MEG equipment, requiring a magnetically shielded room, and high maintenance costs for the helium gas supply. In this study, we share the 306-channel MEG and 3-axis accelerometer signals acquired during three-dimensional reaching movements. Additionally, we provide analysis results and MATLAB codes for time-frequency analysis, F-value time-frequency analysis, and topography analysis. These shared MEG datasets offer valuable resources for investigating brain activities or evaluating the accuracy of prediction algorithms. To the best of our knowledge, this data is the only publicly available MEG data measured during reaching movements.