bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current and potential methods to assess kidney structure and morphology in term and preterm neonates
Authors: Staub Eveline 
Published: March 2023

AbstractAfter birth, the kidney structure in neonates adapt to the functional demands of extrauterine life. Nephrogenesis is complete in the third trimester, but glomeruli, tubuli, and vasculature mature with the rapidly increasing renal blood flow and glomerular filtration. In preterm infants, nephrogenesis remains incomplete and maturation is slower and may be aberrant. This structural and functional deficit has life‐long consequences: preterm born individuals are at higher risk for chronic kidney disease and arterial hypertension later in life. This review assembles the literature on existing and potential methods to visualize neonatal kidney structure and morphology and explore their potential to longitudinally document the developmental deviation after preterm birth. X‐rays with and without contrast, fluoroscopy and computed tomography (CT) involve relevant ionizing radiation exposure and, apart from CT, do not provide sufficient structural details. Ultrasound has evolved into a safe and noninvasive high‐resolution imaging method which is excellent for longitudinal observations. Doppler ultrasound modes can characterize and quantify blood flow to and through the kidneys. Microvascular flow imaging has opened new possibilities of visualizing previously unseen vascular structures. Recent advances in magnetic resonance imaging display renal structure and function in unprecedented detail, but are offset by the logistical challenges of the imaging procedure and limited experience with the new techniques in neonates. Kidney biopsies visualize structure histologically, but are too invasive and remain anecdotal in newborns. All the explored methods have predominantly been examined in term newborns and require further research on longitudinal structural observation in the kidneys of preterm infants.
A thematic analysis of students' discussions on death and body donation in international online focus groups
Authors: Wu Anette , McWatt Sean C. , Utomo Rachel , Talis Austin , Xiao Que Yun , Saraci Kerstin , Brassett Cecilia , Sagoo Mandeep Gill , Wingate Richard , Chien Chung‐Liang , Traxler Hannes , Waschke Jens , Vielmuth Fransziska , Sigmund Anna , Yamada Yukari , Sakurai Takeshi , Zeroual Mina , Olsen Jorgen , El‐Batti Salma , Viranta‐Kovanen Suvi , Keay Kevin , Stewart William , Mao Yinghui , Lang Ariella , Kunzel Carol , Bernd Paulette , Kielstein Heike , Noël Geoffroy P. J. C. 
Published: March 2023

AbstractHistorically, Anatomy education is an in‐person discipline involving exposure to human body donors that facilitates personal and professional growth through, in part, the initiation of reflection on the topic of death. However, during the COVID‐19 pandemic the decreased exposure to cadaveric anatomy for many health professions students may have influenced the depth of their individual reflections on this topic. Accordingly, this study aimed to investigate the effect of an alternate approach—focus group discussions between peers with varying degrees of exposure to cadaveric material—that may offer one strategy to stimulate deep reflection on the topic of death. A programmatic intervention was introduced, wherein students (n = 221) from 13 international universities discussed differences in their anatomy courses during small focus group sessions as part of an online exchange program. An inductive semantic thematic analysis was conducted on responses to an open‐ended text–response question on how the activity influenced students' reflections about death. Resulting themes were organized into categories that described the content and topics of the students' discussions as they grappled with this sensitive topic. The students reportedly engaged in deep reflection and expressed an increased sense of connectedness with their peers, despite their disparate exposure levels to cadaveric anatomy and being physically distanced. This demonstrates that focus groups with students experiencing different laboratory contexts can be used to help all students reflect on the topic of death and that interchanges between dissecting and non‐dissecting students can initiate thoughts about death and body donation among non‐dissecting students.
Growth Reaction of Gold Nanorods in the Presence of Mutated Peptides and Amine‐Modified Single‐Stranded Nucleic Acids
Authors: Sahu Jitendra K. , Singh Omkar , Chakraborty Debashree , Sadhu Kalyan K. 
Published: March 2023

AbstractConformation of biomolecules like DNA, peptides and amino acids play vital role during nanoparticle growth. Herein, we have experimentally explored the effect of different noncovalent interaction between a 5′‐amine modified DNA sequence (NH2−C6H12‐5′‐ACATCAGT‐3′, PMR) and arginine during the seed‐mediated growth reaction of gold nanorods (GNRs). Amino acid‐mediated growth reaction of GNRs results in a snowflake‐like gold nanoarchitecture. However, in case of Arg, prior incubation of GNRs with PMR selectively produces sea urchin‐like gold suprastructures, via strong hydrogen bonding and cation‐π interaction between PMR and Arg. This distinctive structure formation strategy has been extended to study the structural modulation caused by two structurally close α‐helical RRR (Ac‐(AAAAR)3A−NH2) peptide and the lysine mutated KKR (Ac−AAAAKAAAAKAAAARA−NH2) peptide with partial helix at the amino terminus. Simulation studies confirm that a greater number of hydrogen bonding and cation‐π interaction between the Arg residues and PMR resulted in the gold sea urchin structure for RRR peptide against KKR peptide.
Investigating the in vivo effect of Tribulus terrestris extract in middle cerebral artery occlusion rats using LC–MS‐based metabolomics combined with molecular docking
Authors: Li Xingxing , Guo Wenjun , Zhao Liang , Xu Dandan , Xu Xiaohang , Han Yuqing , Wang Chengyan , Jiang Yingzi , Wang Yang , Xu Yajuan 
Published: March 2023

AbstractTribulus terrestris L. fruit (TT) is a traditional Chinese herbal medicine used to treat ischemic stroke (IS). This study aimed to investigate the protective effect of TT extract, named TT15, on middle cerebral artery occlusion (MCAO) rats using metabolomics and molecular docking and find the targets of action and the material basis of TT15 against IS. The results of the infarct volume and neurological defect scores confirmed the efficacy of TT15. Serum metabolomics analysis using LC–MS revealed that model group animals experienced a variety of metabolic disturbances when compared to the sham group. TT15 can restore the MCAO‐induced serum metabolite changes by modulating multiple metabolic pathways. Six enzymes were highlighted by the metabolite‐reaction‐enzyme‐gene (M‐R‐E‐G) network analysis, which might be the possible targets for the TT15 against IS. Molecular docking analysis was applied to show the binding affinities between active compounds and these enzymes. The representative docking mode with the lowest binding energy between three compounds and phospholipase A 2 (PLA2) and peroxidase (POD) was displayed by the ribbon binding map. This study profiles the metabolic changes in MCAO‐induced IS and investigates the efficacy and the corresponding mechanism of TT15 in the treatment of IS.
Acidotic and hypoxic tumor microenvironment induces changes to histone acetylation and methylation in oral squamous cell carcinoma
Authors: Khan Tajwali , Iftikhar Fizza , Akhlaq Rafia , Musharraf Syed Ghulam , Ali Arslan 
Published: March 2023

AbstractHypoxia and acidosis are ubiquitous hallmarks of the tumor microenvironment (TME), and in most solid cancers they have been linked to rewired cancer cell metabolism. These TME stresses are linked to changes in histone post‐translational modifications (PTMs) such as methylation and acetylation, which lead to tumorigenesis and drug resistance. Hypoxic and acidotic TME cause changes in histone PTMs by impacting the activities of histone‐modifying enzymes. These alterations are yet to be extensively explored in oral squamous cell carcinoma (OSCC), one of the most prevalent cancers in developing countries. Hypoxic, acidotic, and hypoxia with acidotic TME affecting histone acetylation and methylation in the CAL27 OSCC cell line was studied using LC–MS–based proteomics. The study identified several well‐known histone marks, in the context of their functionality in gene regulation, such as H2AK9Ac, H3K36me3, and H4K16Ac. The results provide insights into the histone acetylation and methylation associated with hypoxic and acidotic TME, causing changes in their level in a position‐dependent manner in the OSCC cell line. Hypoxia and acidosis, separately and in combination, cause differential impacts on histone methylation and acetylation in OSCC. The work will help uncover tumor cell adaptation to these stress stimuli in connection with histone crosstalk events.
Residue levels of emamectin benzoate, imidacloprid and its major metabolites in cabbage from 12 regions in China and dietary risk assessment
Authors: Zhao Xia , Dong Chao , Hu Jiye 
Published: March 2023

AbstractA modified quick, easy, cheap, effective, rugged and safe method combined with high‐performance liquid chromatography–tandem mass spectrometry was established to investigate the residues of emamectin benzoate (EB), imidacloprid (IMI) and five IMI metabolites (IMI‐olefin, IMI‐urea, IMI‐guanidine, 5‐OH and 6‐CNA) in cabbage. The average recoveries of the seven compounds in cabbage were 80–102%, with relative standard deviations < 8.0%. The limit of quantification for each compound was 0.01 mg kg−1. Standardized residue tests were carried out in 12 areas of China under Good Agricultural Practice conditions. A 10% EB‐IMI microcapsule suspension was applied once with the high recommended dosage (18 g a.i. ha−1) on cabbage. The residues of EB (<0.01 mg kg−1), IMI (<0.016 mg kg−1) and the sum of IMI and its metabolites (<0.068 mg kg−1) in cabbage with the recommended preharvest interval (7 days) were lower than the maximum residue limits in China. Based on residual data from fields, toxicology data and Chinese dietary patterns, dietary risk assessments were conducted. Both the chronic risk quotients (25.2–73.1%) and acute risk quotients (0.43–1.57%) of EB and IMI were below 100%, indicating no unacceptable public health risk for different populations. This study provides guidance on the rational application of these insecticides in cabbage.
Comparing executive functions in children with attention deficit hyperactivity disorder with or without reading disability: A resting‐state EEG study
Authors: Tabiee Maryam , Azhdarloo Ahmad , Azhdarloo Mohammad 
Published: March 2023

AbstractIntroductionAs numerous studies have shown, executive dysfunction is the main impairment in attention‐deficit/hyperactivity disorder. According to recent neuroimaging studies, the frontoparietal coherence plays a key role in overall cognitive functions. Therefore, the aim of this study was to compare executive functions during resting‐state EEG by monitoring brain connectivity (coherence) patterns in children with attention deficit hyperactivity disorder (ADHD) with or without reading disability (RD).MethodsThe statistical sample of the study consisted of 32 children with ADHD aged between 8 and 12 years old with or without specific RD. Each group consisted of 11 boys and 5 girls that were matched on chronological age and gender. EEG was recorded during eyes‐opened condition and brain connectivity within and between frontal and parietal regions was analyzed within theta, alpha, and beta bands.ResultsThe results revealed that across the frontal regions, the comorbid group showed a significant reduction in the left intrahemispheric coherence in the alpha and beta bands. The ADHD‐alone group exhibited increased theta and decreased alpha and beta coherence in frontal regions. In the frontoparietal regions, children in the comorbid group showed lower coherence between frontal and parietal networks compared to children without comorbid RD.ConclusionThe findings indicate that brain connectivity (coherence) patterns of children with ADHD with comorbid RD were more abnormal and lend support to more disrupted cortical connectivity in the comorbid group. Thus, these findings can be a useful marker for better recognizing ADHD and comorbid disabilities.
Circular economy supply network transition phases management dynamics
Authors: Braz Antonio Carlos , de Mello Adriana Marotti 
Published: March 2023

AbstractThis paper discusses transitions towards circular economy, developing a circular economy supply network transition phases management dynamics framework. We studied seven circular supply networks in Brazil through process analysis and system dynamics modeling. Primary data were collected through 35 manager's interviews and companies' plant and their suppliers' visits. We suggest that transition phases management are pre‐development, learning, expansion, leadership, stabilization and self‐renew with cooperative and competitive challenges, characterized by specific circular factors over time. The simulation and transition phases models provide strategic tools to make decision on which circular factor, project team should focus applying multi‐tier supply chain management and hybrid leadership to stimulate internal and integrate external stakeholders to adopt circularity, unveiling challenges and average time to achieve each phase. We also enrich circular economy supply network management theoretical background defining it in three dimensions: behavioral as supply ecosystem, structural as supply network and contextual as complex adaptive system.
Internal cohesion psychotherapy: The nature, principles and application
Authors: Uka Fitim , Gashi Arlinda , Studenica Arvesa 
Published: March 2023

AbstractPsychotherapy is widely used to treat different mental health disorders and emotional difficulties. The main objective of psychotherapy is to help clients become aware of and have control over their thoughts, moods, feelings and behaviours, as well as create healthy strategies to respond to challenging situations. Since the existing psychotherapy approaches and other methods of treatment are not always effective in treating mental health disorders, there is still space for new approaches to fill this gap. In this paper, we provide information about internal cohesion psychotherapy, which is a new integrative approach. This paper presents a new approach to eclectic psychotherapy, focussing on four detrimental aspects of human functioning through different time perspectives.
Partners in crime: A 21‐year cohort comparison of people who commit serious crimes together with those who act alone
Authors: Ahlgren‐Rimpilainen Aulikki Johanna , Rautanen Mika 
Published: March 2023

AbstractBackgroundPerpetrators who act together violently occur frequently in police and media discussions, but are rarely the focus of forensic psychiatric research.AimsWe aimed to characterise people who act together when committing a serious crime and to map the frequency of such crimes over 21 years in Finland.MethodsData for the study were retrieved from the national database of forensic psychiatric examinations for the period 2000–2020, with reports on file for nearly all people charged with serious criminal offences in the country. Index cases were defined as those with two or more perpetrators attacking a single victim; people who acted alone were comparison cases. Sex and age at the time of the crime were extracted together with all diagnoses listed in the reports.ResultsSeventy‐five multiple perpetrator groups (MPG) were identified, accounting for 165 individuals whose reports were compared with 2494 single‐perpetrator (SPR) reports. Most group and solitary offenders were male (87%: 86%, respectively). The index offence was more likely to be homicide among the group perpetrators (mean 1.12) than the solitary offenders (mean 0.83). Proportionately more of the group offenders had personality disorder or substance use disorders (antisocial personality disorder MPG 49%: SPR 32%; any personality disorder MPG 89%: SPR 76%); alcohol (MPG 79%: SPR 69%; cannabis MPG 15%: SPR 9%). By contrast, psychosis was about twice as common among the solitary offenders (MPG 12%; SPR 26%).ConclusionsThe number of group‐perpetrated crimes has not increased, according to these Finnish forensic psychiatric report data of 2000–2020, but the relatively high prevalence among them of personality and substance use disorders is a constant. Understanding psychiatric disorders as factors in both leading to and avoiding violent conflicts may help plan new approaches to further diminish group violence.
Right atrial thrombus and pulmonary thromboembolism related to ovarian hyperstimulation syndrome: A case report and literature review
Authors: Sayyadi Amin , Mahdavi Mahsa , Dalfardi Behnam , Karami Robati Fatemeh , Shafiepour Mohsen 
Published: March 2023

AbstractA young lady with a history of infertility presented to the hospital with dyspnea and chest pain a few days after ovulation induction. Her manifestations were consistent with ovarian hyperstimulation syndrome (OHSS). Further investigations revealed right atrial thrombus and pulmonary thromboembolism. We successfully managed the condition with conservative therapy.
Secondary oxalate nephropathy and impact of high‐dose vitamin C intake for COVID‐19 prevention on a patient with Roux‐en‐Y gastric bypass: A case report
Authors: Kafi Fatemeh , Mortazavi Mojgan , Pouramini Alireza , Dolatkhah Shahaboddin , Kaleidari Behrouz , Taheri Diana 
Published: March 2023

AbstractThe current study is important in informing clinicians about the possibility of concurrent oxalate nephropathy caused by Roux‐en‐Y gastric bypass, high oxalate materials, and high‐dose vitamin C intake for COVID‐19 prevention.
Multiple endocrine neoplasia type 1 familial case in a patient with insulinoma and primary hyperparathyroidism: First report in literature and in the Costa Rican population of the c.1224_1225insGTCC pathogenic variant
Authors: Molina‐Céspedes Paula , Ruiz‐Golcher Ernesto José , Badilla‐Barboza Oscar , Sedó‐Mejía Giovanni , Barboza‐Rodríguez Laura , Badilla‐Porras Ramsés 
Published: March 2023

AbstractMultiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disorder without a good genotype–phenotype correlation, characterized by tumor predisposition in the parathyroid gland, anterior pituitary, and pancreatic islet cells. Here, we describe a 37‐year‐old male with previous history of nephrolithiasis, with a 1‐year history of recurrent hypoglycemic episodes. Physical examination revealed the presence of two lipomas. Family history revealed primary hyperparathyroidism (PHPT), hyperprolactinemia, and multiple non‐functioning pancreatic neuroendocrine tumors. Initial laboratories revealed hypoglycemia and primary hyperparathyroidism. A fasting test was positive after 3 hours of initiation. An abdominal CT Scan demonstrated a 28 × 27 mm mass in the pancreatic tail and bilateral nephrolithiasis. A distal pancreatectomy was done. After surgery, the patient persisted with hypoglycemic episodes that were managed with diazoxide and frequent feedings. A parathyroid Tc‐99 m MIBI scan with SPECT/CT imaging demonstrated two hot uptake lesions compatible with abnormally functioning parathyroid tissue. Surgical treatment was offered; however, the patient decided to postpone the procedure. Direct sequence analysis of MEN1 gene revealed heterozygosity for a pathogenic insertion c.1224_1225insGTCC (p.Cys409Valfs*41). DNA sequence analysis was done to six of his first‐degree relatives. A sister with clinical diagnosis of MEN1 and a pre‐symptomatic brother were positive for the same MEN1 variant. To our knowledge, this is the first report of a genetically confirmed case of MEN1 in our country and is the first report in literature of the c.1224_1225insGTCC variant related to a clinically affected family.
A case of needle tract seeding that seemed to be caused by endoscopic ultrasound‐guided fine‐needle aspiration
Authors: Sekine Masanari , Asano Takeharu , Kurabayashi Risako , Maeda Shimpei , Watanabe Fumiaki , Noda Hiroshi , Rikiyama Toshiki , Mashima Hirosato 
Published: March 2023

AbstractA 66‐year‐old man underwent a single endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) session and distal pancreatectomy for the pancreatic body adenocarcinoma measuring 12 mm in diameter. At 3 years after surgery, we diagnosed needle tract seeding (NTS) and performed total gastrectomy. NTS can occur with small tumors or after a single session of EUS‐FNA.
Improvement of depressive symptoms, after a suicide attempt, with dextromethorphan/bupropion combination treatment in a patient with treatment‐resistant depression and psychiatric comorbidities
Authors: Pedraz‐Petrozzi Bruno , Deuschle Michael , Gilles Maria 
Published: March 2023

AbstractWe admitted a 42‐year‐old patient with severe treatment‐resistant depression and with psychiatric comorbidities. The patient attempted suicide 5 weeks after admission. Subsequently, we initiated dextromethorphan/bupropion based on prior evidence. As a result, the patient demonstrated an improvement in mood symptoms and a reduction in suicide risk, leading to her discharge.
Cervical spondylotic myelopathy presenting as a “pancake enhancement” on MRI of the spinal cord: A case report and review of literature
Authors: Sharma Nava Raj , Sharma Bharosa , Lamichhane Saral , Pokhrel Madalasa , Shrestha Prajwal 
Published: March 2023

AbstractSpondylotic myelopathy involves chronic spinal cord compression from degenerative spine changes presenting a myriad of neurological and pain symptoms. We report a case of cervical myelopathy with transverse pancake‐like gadolinium enhancement seen on MRI in a 42‐year‐old gentleman with progressive bilateral upper extremity numbness, tingling, and impaired gait.
Hybrid Organometallic and Enzymatic Tandem Catalysis for Oxyfunctionalisation Reactions
Authors: Domestici Chiara , Wu Yinqi , Hilberath Thomas , Alcalde Miguel , Hollmann Frank , Macchioni Alceo 
Published: March 2023

AbstractUnspecific peroxygenases (UPOs) are promising biocatalysts for oxyfunctionalisation reactions, owing to their simplicity of handling, stability and robustness. A limitation of using UPOs on a large scale is their deactivation in the presence of even rather modest concentrations of H2O2, requiring a constant and controlled supply of low amount of H2O2. Herein, we report an organometallic complex [Cp*Ir(pica)NO3] {pica=picolinamidate=κ2‐pyridine‐2‐carboxamide ion (−1)} 1 capable of efficiently regenerating FMNH2 from FMN (TOF=350 h−1, 298 K), driven by NaHCOO; FMNH2, in turn, spontaneously reacts with O2 leading to H2O2. After having studied the compatibility of 1 with the UPO from Agrocybe aegerita (rAaeUPO PaDa‐I) and individuated the best experimental conditions, we applied such a hybrid catalytic tandem in some hydroxylation, epoxidation and sulfoxidation reactions. Best performances were obtained by using a 1/rAaeUPO molar ratio of 50. TONs for the biocatalyst of up to 18933 were obtained for the transformation of ethylbenzene derivatives into (R)‐1‐phenylethanols (ee>99 %). 1/rAaeUPO was found to oxidise also cis‐methyl styrene (TON=13488), leading exclusively (1R,2S)‐cis‐methyl styrene oxide (ee>99 %), cyclohexane (TON=1634) and thioanisole (TON=1369).