bluuebunny/crossref_metadata_2025_split huggingface dataset:
To the question of application of new physical and chemical geotechnologies in the development of uranium ore deposits
Authors: Panov Yu. P. , Bryukhovetsky O. S. , Sekisov A. G. 
Published: May 2023

Background. Underground uranium leaching is a promising geotechnological process due to its potential to provide for a radical increase in the technical and economic efficiency, as well as environmental safety, of uranium deposit development. In this article, we discuss the main results in this direction obtained by specialists of the Russian State University for Geological Prospecting.Aim. To study the processes of uranium leaching by activated solutions, which undergo electrophotochemical treatment prior to contacting with the ore.Materials and methods. Activation preparation of leaching solutions enables the synthesis of active hydrated forms of oxygen and hydrogen with collectivized protons and hydroxyl ions clustered by water molecules. Following the stage of pre-oxidation with an active carbonate solution, a model downhole leaching with chloride-hypochlorite, soda, and sulfuric acid solutions was carried out. Testing percolation leaching of uranium from the ores of the Uchkuduk and Sugraly deposits by activated solutions was conducted at laboratory installations designed by the the Russian State University for Geological Prospecting jointly with the Institute of Mining of Far-East Branch of the Russian Academy of Sciences and Zabaikalsky State University. As a result, the potential of a significant increase in uranium extraction was noted.Results. When leaching with sodium carbonate and ammonium carbonate solutions, the uranium extraction from ore samples from the Sugraly deposit comprised 52% and 59%, respectively. At the same time, the use of an activated solution of sodium percarbonate, which combines the functions of an oxidizing agent and a complexing agent, resulted in an 87–88% uranium extraction into productive solutions during 21 days without preliminary pre-oxidation.Conclusion. The results obtained confirm the prospects of using mine (block) and downhole uranium leaching with activated solutions.
Aplicación de la geometría como sustento al diseño arquitectónico en estudiantes de segundo nivel
Authors: Jordán Buenaño Nancy de Lourdes , Tipán Renjifo Diego Marcelo , Gualpa Naranjo Lizeth Valeria , Espinosa Pinos Carlos Alberto 
Published: May 2023

Introducción: El presente análisis parte de la indagación de la formación académica del arquitecto y la aplicación de los contenidos de la geometría con los distintos proyectos que se dictan en segundo semestre de la carrera de arquitectura pretendiendo superar el tradicionalismo de los modelos pedagógicos mediante la solución a las necesidades concretas del contexto, a más de tener muy claro el trabajo investigativo que genere el estudio, y mostrar resultados analíticos, y objetivos mediante el proyecto integrador quien brinda habilidades y competencias a desarrollar en la solución de un problema. Objetivos: Se plantea como objetivo la aplicación de contenidos de los proyectos formativos mediante actividades pedagógicas para el desarrollo interdisciplinar y transdisciplinar en un diseño arquitectónico innovador partiendo del origen de la geometría como área específica de las Matemáticas. Metodología: está orientado a la descripción e interpretación de las combinaciones fundamentales de la experiencia y del significado del valor pedagógico aplicado en los estudiantes, quienes respaldan el ejercicio práctico y actividades en el proceso proyectual en arquitectura y urbanismo, por otro lado, el enfoque metodológico empleado fue fenomenológico- hermenéutico, encaminado a la interpretación y reconocimiento de relaciones y prácticas propias de la pedagogía cotidiana exhibiendo y aportando desde la indagación educativa y la práctica investigativa. Resultados: Él estudiante está preparado para analizar el contexto de forma especializada y competitiva mediante la vinculación con la docencia y el trabajo práctico de la integración, reconociendo el argumento que encaje con todas las características para la elaboración del diseño de un centro cultural mediante el uso de los contenidos de geometría al plasmar un objeto arquitectónico con todos sus componentes. Conclusiones: Se concluyó que, la práctica de integración de conocimientos de los distintos proyectos formativos y de la geometría en la arquitectura, contribuyen con el perfil profesional del arquitecto, capacitando al estudiante para crear nuevos conocimientos e identificar las problemáticas del contexto y plasmar en el diseño de obras arquitectónicas que se visualicen en forma proporcional y armónica. Área de estudio general: Arquitectura. Área de estudio específica: Geometría.
Métodos alternativos de solución de conflictos en la recuperación de la cartera educativa
Authors: Rodríguez Pacheco Pamela Alexandra 
Published: May 2023

Introducción. “Métodos alternativos de solución de conflictos en la recuperación de la Cartera Educativa”, es el punto de partida del presente estudio, efectuado considerando que la ley suprema reconoce el arbitraje y la mediación como procedimientos para solucionar un conflicto; lamentablemente algunos los ciudadanos, especialmente los administradores de las instituciones educativas particulares desconocen estas tácticas y acuden a la justicia ordinaria, contribuyendo a la acumulación de los procesos en las entidades de justicia a nivel nacional, siendo la mayor preocupación vivir en una cultura problemática y conflictiva, agravándose con el transcurso del tiempo. Al respecto, la mediación orienta hacia la solución de los conflictos mediante el fortalecimiento de los canales y formas de comunicación que orienten hacia la comprensión y reconocimiento mutuo. Objetivos. Analizar la importancia de los métodos alternativos de solución de conflictos en la recuperación de la Cartera Educativa. Fundamentar teóricamente el derecho a la educación. Identificar los métodos alternativos de solución de conflictos, determinar la importancia de la recuperación de cartera en educación privada. Metodología. Se aplica la investigación bibliográfica mediante la realización de una revisión bibliográfica documental. Resultados. Los métodos de solución son procedimientos alternativos, así, la negociación, la mediación, el arbitraje, la conciliación y la transacción, incluyen disposiciones que son aplicadas con sujeción a la ley, para llegar a acuerdos por delegación de la autoridad competente, con responsabilidad compartida e iniciativas que contribuyan al buen vivir. Conclusiones. La mediación y la negociación cumplen un rol fundamental en los esfuerzos por mejorar el funcionamiento de los sistemas judiciales, la convivencia social y la competitividad económica. Área de estudio general: Derecho. Área de estudio específica: Mediación y Arbitraje.
PERAN VIDEO EDITOR DALAM PEMBUATAN PROGRAM FEATURE BERJUDUL “THE BEAUTY OF SAMOSIR ISLAND”
Authors: Naufal Muhamad Reza , Suhendra Atma 
Published: May 2023

Abstrak. Kepulauan Samosir memiliki kekayaan budaya yang sangat menarik bagi para wisatawan. Berdasarkan data pada Dispar Kabupaten Samosir, pada tahun 2020 yang berkunjung ke Pulau Samosir mencapai 405.203 kunjungan. Hanya menurun sedikit dari tahun 2019, yakni 418.271 kunjungan. Adanya kasus pariwisata seperti ini, bukan hanya kekurangan dari pengembangan potensi objek wisata, tetapi adanya kekurangan dari minimnya sebuah pemberdayaan warga lokal untuk berpartisipasi dalam pengembangan industri pariwisata di daerahnya. Oleh karena itu Pencipta karya ingin memberikan tayangan untuk mengeksplorasi dan menganalisis kearifan lokal budaya Batak Toba, yang dapat mendukung sektor pariwisata di Pulau Samosir. Tayangan ini merupakan program feature dengan judul “THE BEAUTY OF SAMOSIR ISLAND” yang menjelaskan bagaimana upaya dalam pelestarian nilai-nilai kebudayaan Batak toba agar dapat menarik wisatan untuk berkunjung ke pulau samosir. Peran penulis sebagai editor yang mengemas film ini menjadi menarik dan mengandung isi dari film tersebut agar dapat mudah di pahami oleh penonton. Proses pembuatan program feature melalui tiga tahap yaitu ini melalui tiga tahap yaitu pra produksi, produksi dan pasca produksi. Untuk tahap Pra produksi adalah tahapan perencanaan sebelum produksi mulai dari ikut dalam memberikan Ide Konsep, Proses Produksi sebagai editor memantau proses syuting untuk memastikan hasil gambar terpenuhi dan tidak ada kekurangan angle dalam melakukan proses editing, Proses Pasca Produksi tahap pengeditan yang dilakukan secara offline dan online, penyesuaian antara gambar, grading dan audio.
Optic Disc Detection on Retina Image using Extreme Learning Machine
Authors: Wibawa Helmie Arif , Sutikno Sutikno , Sasongko Priyo Sidik 
Published: May 2023

Optic disk detection on retina image has become one of many initial steps in evaluation of Diabetic Macular Edema (DME) severity. As much as early the step is, the result of the step is extremely essential. This article discusses the optic disk detection on retina image based on the color histogram value. The detection is done by using color histogram value which is taken from window sliding process with the size of 50x50 pixels. First, the candidates of optic disc were detected using Extreme Learning Machine towards the histogram value. Then the optic disc was selected form the candidates of optic which has highest average intensity. 4 retina image datasets were employed in the evaluation, including Drions dataset, DRIVE dataset, DiaretDB1 dataset, and Messidor dataset. The result of evaluation then validated by medical expert. The model outcome reaches the accuracy as much as 85,39 % for DiaretDB1 dataset, 95% for DRIVE dataset, 98,18% for Drions and 99% for Messidor dataset.
Pet Care Information System at Darussalam Pet Shop Based on Android
Authors: Syafitri Siti , Suendri Suendri 
Published: May 2023

Modern technology has changed people's lifestyles, including how to raise pets. Pet is an animal kept at home or in a cage and exclusively cared for by its owner. Recently, more people owning pets. This had led to questions related to the hygiene and health of pets. An unkempt pet can cause problems for the owner, so numerous pet stores have emerged to help owners provide their animals with the care they require. However, many pet shops still use a manual system, which is considered ineffective for service, and utilizing information technology will make jobs easier while improving accuracy and information quality. Based on the problems described above, an application is required to assist and facilitate the pet shop itself and customers in caring for their pets. The research goal is to design and build suitable applications. In this journal, the researcher utilized both the Quantitative research methods and the Waterfall method for application development. For testing, the researcher used the Likert Scale. The Likert Scale calculation yielded a total score of 80.3 (Satisfied). Therefore, it can be concluded that the application is operating as intended and makes it easier to obtain pet-related information for user and manage schedules and incoming orders for administrators.
Analysis of Resistance to Fungal Pathogen Hemileia Vastatrix of Liberica Coffee Based on Functional Marker
Authors: Wahibah Ninik N. , Putri Rizka P. , Muflikhah Lailil , Martina Atria , . Arini 
Published: May 2023

Coffee Leaf Rust (CLR) disease caused by fungal pathogen Hemileia vastatrix is one of devastated diseases in coffee plants. Disease RGA (resistance gene analog) primer pair CARF 005 has been reported for leaf rust-resistant screening in Arabica coffee and has never been reported in Liberica coffee. Previously, Liberoid Meranti 1 and 2 (Lim 1 and Lim 2) from Meranti Islands Indonesia were officially published by the government as CLR resistant cultivars and adaptive to peat soil. Our study aimed to analyze the resistance of Liberica coffee plants based on functional primer CARF 005. We sampled healthy plants of three Liberica genotypes (Lim 1, Lim 2, Bengkalis) in commercial farmer fields. DNA was extracted from young leaves, amplified and sequenced using CARF 005 primers. All samples generated DNA band about 400 bp. In addition, nucleotide sequences are similar to Arabica putative disease resistance gene. All the three sequences contain NB-ARC conserved domain which contribute to pathogenic-resistant trait. The regions also contain one motif sequence of P-loop/Walker-A domain. Our result confirmed that DNA fragments amplified by CARF 005 are linked to RGA region and eventually we suggested that CARF 005 can be used to identify resistance to CLR in Liberica. It will particularly contribute for supporting Liberica breeding program and conservation of Liberica germplasm
Matrilin-2 within a three-dimensional lysine-modified chitosan porous scaffold enhances Schwann cell migration and axonal outgrowth for peripheral nerve regeneration
Authors: Li Neill Y. , Vorrius Brandon , Ge Jonathan , Qiao Zhen , Zhu Shuang , Katarincic Julia , Chen Qian 
Published: May 2023

Background: Matrilin-2 is a key extracellular matrix protein involved in peripheral nerve regeneration. We sought to develop a biomimetic scaffold to enhance peripheral nerve regeneration by incorporating matrilin-2 within a chitosan-derived porous scaffold. We hypothesized that the use of such a novel biomaterial delivers microenvironmental cues to facilitate Schwann cell (SC) migration and enhance axonal outgrowth during peripheral nerve regeneration.Materials and Methods: The effect of matrilin-2 on SC migration was evaluated with agarose drop migration assay on matrilin-2 coated dishes. SC adhesion was determined with SCs cultured atop tissue culture dishes coated with matrilin-2. Various formulations of chitosan vs matrilin-2 in scaffold constructs were examined with scanning electron microscopy. The effect of the matrilin-2/chitosan scaffold on SC migration in the collagen conduits was determined by capillary migration assays. Neuronal adhesion and axonal outgrowth were evaluated with three-dimensional (3D) organotypic assay of dorsal root ganglions (DRG). DRG axonal outgrowth within the scaffolds was determined by immunofluorescence staining of neurofilaments.Results: Matrilin-2 induced SC migration and enhanced its adhesion. A formulation of 2% chitosan with matrilin-2 demonstrated an optimal 3D porous architecture for SC interaction. Matrilin-2/chitosan scaffold enabled SCs to migrate against gravity within conduits. Chemical modification of chitosan with lysine (K-chitosan) further improved DRG adhesion and axonal outgrowth than the matrilin-2/chitosan scaffold without lysine modification.Conclusion: We developed a matrilin-2/K-chitosan scaffold to mimic extracellular matrix cues and provide a porous matrix to enhance peripheral nerve regeneration. Taking advantage of matrilin-2’s capability to stimulate SC migration and adhesion, we formulated a porous matrilin-2/chitosan scaffold to support axongal outgrowth. Chemical modification of chitosan with lysine further improved matrilin-2 bioactivity in the 3D scaffold. The 3D porous matrilin-2/K-chitosan scaffolds have high potential for enhancing nerve repair by stimulating SC migration, neuronal adhesion, and axonal outgrowth.
Mucuna pruriens cannot develop phytoremediation of tebuthiuron in agricultural soil with vinasse: a morphometrical and ecotoxicological analysis
Authors: Frias Yanca Araujo , Lima Edivaldo Wilson , Aragão Munick Beato , Nantes Laura Silva , Moreira Bruno Rafael Almeida , Cruz Victor Hugo , Tomaz Rafael Simões , Lopes Paulo Renato Matos 
Published: May 2023

Pesticides offer stakeholders cost-effective solutions to control weeds. Nevertheless, such active compounds can manifest as severe environmental pollutants when escaping from agroecosystems into surrounding natural ecosystems, driving the need to remediate them. We, hence, analyzed whether Mucuna pruriens can develop a potential phytoremediator for treating tebuthiuron (TBT) in soil with vinasse. We exposed M. pruriens to microenvironments containing tebuthiuron at 0.5, 1, 1.5, and 2 (standard dose) L ha−1 and vinasse at 75, 150 (industrial recommendation), and 300 m3·ha−1. Experimental units without organic compounds represented controls. We assessed M. pruriens for morphometrical features, such as plant height and stem diameter and shoot/root dry mass, over approximately 60 days. We obtained evidence for M. pruriens not effectively removing tebuthiuron from the terrestrial medium. Such a pesticide developed phytotoxicity, significantly limiting its germination and growth. The higher the dose, the more negatively the tebuthiuron impacted the plant. In addition, introducing vinasse into the system, irrespective of volume, intensified the damage to photosynthetic and non-photosynthetic structures. Equally important, its antagonist action further decreased the production and accumulation of biomass. As M. pruriens could not effectively extract tebuthiuron from the soil, it could allow neither Crotalaria juncea nor Lactuca sativa to grow on synthetic media containing residual pesticide. An atypical performance of such testing (tebuthiuron-sensitive) organisms over independent ecotoxicological bioassays validated inefficient phytoremediation. Hence, M. pruriens could not offer a functional remediative option to treat environmental pollution by tebuthiuron in agroecosystems where vinasse occurs, such as sugarcane-producing areas. Although M. pruriens considered a tebuthiuron phytoremediator as cited in the literature, satisfactory results did not occur in our research due to high concentrations of vinasse in the soil. Therefore, this information requires more specific studies about the influence of high concentrations of organic matter on M. pruriens productivity and phytoremediation performance.
An experimental study and axial tensile constitutive model of the toughness of PP-SACC for rapid repairs
Authors: Xie Wen , Xu Xuefeng , Xu Chunlei , Tian Feng , Mao Qiwen , Li Helong , Liu Lin , Qin Gongyi 
Published: May 2023

To improve the economic benefits of engineered cementitious composites and control the repair cycle, repair materials were designed, with the key components of the mixture being low-cost polypropylene (PP) fibers and fast-setting sulfoaluminate cement. The effects of water/binder ratio, fiber content, and aggregate particle size on the flowability, mechanical properties, and toughness of the polypropylene fiber-reinforced sulfoaluminate cementitious composite (PP-SACC) were explored. Based on experimentally measured axial tensile stress–strain curves, a constitutive model of PP-SACC was derived in terms of fiber content and water/binder ratio. Additionally, the correlation coefficients representing the relationships of the mixture indices with the tensile properties were explored based on revised gray relational analysis. Test results indicated that fiber content and water/binder ratio were the most important factors affecting the mechanical properties, toughness, and fluidity of the material; in contrast, the influence of aggregate size was slight. The PP-SACC mixture with an aggregate size of 75 µm, a water/binder ratio of 0.30, and a fiber content of 3.0% demonstrated an excellent degree of toughness and exhibited a flexural hardening phenomenon under bending load.
Recent progress in experimental studies on the catalytic mechanism of cytochrome c oxidase
Authors: Shimada Atsuhiro , Tsukihara Tomitake , Yoshikawa Shinya 
Published: May 2023

Cytochrome c oxidase (CcO) reduces molecular oxygen (O2) to water, coupled with a proton pump from the N-side to the P-side, by receiving four electrons sequentially from the P-side to the O2-reduction site—including Fea3 and CuB—via the two low potential metal sites; CuA and Fea. The catalytic cycle includes six intermediates as follows, R (Fea32+, CuB1+, Tyr244OH), A (Fea32+-O2, CuB1+, Tyr244OH), Pm (Fea34+ = O2−, CuB2+-OH−, Tyr244O•), F (Fea34+ = O2−, CuB2+-OH-, Tyr244OH), O (Fea33+-OH-, CuB2+-OH−, Tyr244OH), and E (Fea33+-OH-, CuB1+-H2O, Tyr244OH). CcO has three proton conducting pathways, D, K, and H. The D and K pathways connect the N-side surface with the O2-reduction site, while the H-pathway is located across the protein from the N-side to the P-side. The proton pump is driven by electrostatic interactions between the protons to be pumped and the net positive charges created during the O2 reduction. Two different proton pump proposals, each including either the D-pathway or H-pathway as the proton pumping site, were proposed approximately 30 years ago and continue to be under serious debate. In our view, the progress in understanding the reaction mechanism of CcO has been critically rate-limited by the resolution of its X-ray crystallographic structure. The improvement of the resolutions of the oxidized/reduced bovine CcO up to 1.5/1.6 Å resolution in 2016 provided a breakthrough in the understanding of the reaction mechanism of CcO. In this review, experimental studies on the reaction mechanism of CcO before the appearance of the 1.5/1.6 Å resolution X-ray structures are summarized as a background description. Following the summary, we will review the recent (since 2016) experimental findings which have significantly improved our understanding of the reaction mechanism of CcO including: 1) redox coupled structural changes of bovine CcO; 2) X-ray structures of all six intermediates; 3) spectroscopic findings on the intermediate species including the Tyr244 radical in the Pm form, a peroxide-bound form between the A and Pm forms, and Fr, a one-electron reduced F-form; 4) time resolved X-ray structural changes during the photolysis of CO-bound fully reduced CcO using XFEL; 5) a simulation analysis for the Pm→Pr→F transition.
The Amplatzer duct occluder (ADOII) and Piccolo devices for patent ductus arteriosus closure: a large single institution series
Authors: Bruckheimer Elchanan , Steiner Kristoffer , Barak-Corren Yuval , Slanovic Leonel , Levinzon Michael , Lowenthal Alexander , Amir Gabriel , Dagan Tamir , Birk Einat 
Published: May 2023

PurposeEvaluate Piccolo and ADOII devices for transcatheter patent ductus arteriosus (PDA) closure. Piccolo has smaller retention discs reducing risk of flow disturbance but residual leak and embolization risk may increase.MethodsRetrospective review of all patients undergoing PDA closure with an Amplatzer device between January 2008 and April 2022 in our institution. Data from the procedure and 6 months follow-up were collected.Results762 patients, median age 2.6 years (range 0–46.7) years and median weight 13 kg (range 3.5–92) were referred for PDA closure. Overall, 758 (99.5%) had successful implantation: 296 (38.8%) with ADOII, 418 (54.8%) with Piccolo, and 44 (5.8%) with AVPII. The ADOII patients were smaller than the Piccolo patients (15.8 vs. 20.5 kg, p &lt; 0.001) and with larger PDA diameters (2.3 vs. 1.9 mm, p &lt; 0.001). Mean device diameter was similar for both groups. Closure rate at follow-up was similar for all devices ADOII 295/296 (99.6%), Piccolo 417/418 (99.7%), and AVPII 44/44 (100%). Four intraprocedural embolizations occurred during the study time period: two ADOII and two Piccolo. Following retrieval the PDA was closed with an AVPII in two cases, ADOI in one case and with surgery in the fourth case. Mild stenosis of the left pulmonary artery (LPA) occurred in three patients with ADOII devices (1%) and one patient with Piccolo device (0.2%). Severe LPA stenosis occurred in one patient with ADOII (0.3%) and one with AVPII device (2.2%).ConclusionsADOII and Piccolo are safe and effective for PDA closure with a tendency to less LPA stenosis with Piccolo. There were no cases of aortic coarctation related to a PDA device in this study.