bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stale bread waste recycling as ingredient for fresh oven‐baked white bread: effects on dough viscoelasticity, bread molecular organization, texture, and starch digestibility
Authors: García‐Hernández Ángeles , Roldán‐Cruz César , Vernon‐Carter Eduardo Jaime , Alvarez‐Ramirez Jose 
Published: January 2023

AbstractBACKGROUNDWasted food produced for human consumption is estimated at 33% globally, and bread is the food product with the highest percentage. There is an ongoing drive to reincorporate food waste still useful and safe into the production chain of food for human consumption. This work aims to contribute to the study of the feasibility of recycling stale bread waste flour (BWF) into fresh oven‐baked white bread, by replacing 0, 20, 40, 60, 80, and 100 g/100 g of the wheat flour with BWF.RESULTSStorage and loss moduli increased as the BWF content increased. The baked loaf exhibited decreased lightness and yellowness but increased redness. Increasing BWF contents produced decreased loaf volume and hardness but increased moisture content. Fourier‐transform infrared analysis showed that the BWF addition induced important changes in the water, protein, and starch molecular organization. Therefore, starch digestibility showed reductions in both rapidly and slowly digestible starch fractions. Principal component analysis revealed that replacements of up 20 g/100 g can produce white bread with textural, colour, and starch digestibility characteristics like that of the control bread.CONCLUSIONThe fresh oven‐baked white bread variation produced by replacing 20 g/100 g of the wheat flour with BWF exhibited comparable colour, volume, texture, and starch digestibility features as a control bread did made with 0 g/100 BWF. Higher replacement percentages of wheat flour by stale BWF produced unsuitable drawbacks in the white bread characteristics, but those might be deemed as convenient in other types of bakery products. © 2023 Society of Chemical Industry.
Contemporary issues in the surgical management of pleural mesothelioma
Authors: Paajanen Juuso , Jaklitsch Michael T. , Bueno Raphael 
Published: January 2023

AbstractThe surgical management of pleural mesothelioma (PM) can be divided into diagnostic, staging, palliation, and cytoreductive surgery. In the cytoreductive surgical setting, the combination of different treatment modalities has led to better outcomes than surgery alone. The scarcity of high‐quality studies has led to heterogeneity in management of PM across the mesothelioma treatment centers. Here, we review the literature regarding the most important open questions and ongoing clinical trials.
Sublobar resections for lung cancer: Finally, some answers and some more questions?
Authors: Swanson Scott J. , White Abby 
Published: January 2023

AbstractThe Lung Cancer Study Group Trial, published in 1995, set the tone for lobectomy as the standard of care for early‐stage nonsmall cell lung cancer. Twenty‐seven years and two randomized trials later, does the thoracic oncology community have clarity regarding the choice type of resection, or more questions?
Peritoneal metastases from primary appendiceal and colorectal carcinomas demonstrate distinct molecular identities on comprehensive tumor analysis
Authors: Fleming Andrew M. , Deschner Benjamin W. , Williard Forrest W. , Drake Justin A. , Vanderwalde Ari , Xiu Joanne , Somer Bradley G. , Yakoub Danny , Tsao Miriam W. , Glazer Evan S. , Dickson Paxton V. , Shibata David , Philip Philip A. , Hwang Jimmy J. , Shields Anthony F. , Marshall John L. , Korn W. Michael , Lenz Heinz‐Josef , Deneve Jeremiah L. 
Published: January 2023

AbstractBackground and ObjectivesPublished data comparing peritoneal metastases from appendiceal cancers (pAC) and colorectal cancers (pCRC) remain sparse. We compared pAC and pCRC using comprehensive tumor profiling (CTP).MethodsCTP was performed, including next‐generation sequencing and analysis of copy number variation (CNV), microsatellite instability (MSI) and tumor mutational burden (TMB).ResultsOne hundred thirty‐six pAC and 348 pCRC samples underwent CTP. The cohorts' age and gender were similar. pCRC demonstrated increased pathogenic variants (PATHs) in APC (48% vs. 3%, p < 0.01), ARID1A (12% vs. 2%, p < 0.01), BRAF (12% vs. 2%, p < 0.01), FBXW7 (7% vs. 2%, p < 0.01), KRAS (52% vs. 41%, p < 0.05), PIK3CA (15% vs. 2%, p < 0.01), and TP53 (53% vs. 23%, p < 0.01), and decreased PATHs in GNAS (8% vs. 31%, p < 0.01). There was no difference in CNV, fusion rate, or MSI. Median TMB was higher in pCRC (5.8 vs. 5.0 mutations per megabase, p = 0.0007). Rates of TMB‐high tumors were similar (pAC 2.1% vs. pCRC 9.0%, p = 0.1957). pCRC had significantly more TMB‐high tumors at lower thresholds.ConclusionsDespite a reduced overall TMB, pAC demonstrated mutations distinct from those seen in pCRC. These may serve as discrete biomarkers for future study.
The impact of trauma‐focused psychotherapy for posttraumatic stress disorder on interpersonal functioning: A systematic review and meta‐analysis of randomized clinical trials
Authors: Swerdlow Benjamin A. , Baker Shelby N. , Leifker Feea R. , Straud Casey L. , Rozek David C. , Sippel Lauren M. 
Published: January 2023

AbstractInterpersonal functioning is a common concern for people with postttraumatic stress disorder (PTSD) but is not a key target of most trauma‐focused psychotherapies (TFPs). We preregistered and undertook a systematic review and meta‐analysis of randomized clinical trials (RCTs) examining the efficacy of TFPs for improving interpersonal functioning. Studies were identified through the PTSD Trials Standardized Data Repository, scholarly databases, and the solicitation of unpublished data from the PTSD research community following current PRISMA guidelines. We used random effects meta‐analysis to estimate within‐group change (i.e., pre‐ to posttreatment) in interpersonal functioning. Meta‐analytic findings yielded a medium total effect of TFP on interpersonal functioning, g = 0.54, 95% CI [0.37, 0.72], with high between‐study heterogeneity. Sensitivity analyses yielded substantively equivalent point estimates when outliers were excluded, g = 0.55, and when only the most well‐established individual TFPs were included, g = 0.57. In contrast, allocation to a control condition was associated with little average change in interpersonal functioning, g = 0.04 [‐0.12, 0.21]. Formal tests did not yield clear evidence of publication bias. Bias‐corrected estimates varied but centered around a medium effect, gs = 0.41–1.11. There was a medium‐to‐large association between change in interpersonal functioning and change in PTSD symptoms, rs = ‐.35–‐.44. The extant literature on TFPs and interpersonal functioning is small and heterogeneous, indicating the need for more focused attention on this outcome. Results suggest that, on average, TFPs are moderately efficacious for improving interpersonal functioning; however, additional treatment may be needed to meet the desired level of improvement
Amphiphilic Poly(vinyl alcohol) Membranes Leaving Out Chemical Cross‐Linkers: Design, Synthesis, and Function of Tailor‐Made Poly(vinyl alcohol)‐b‐poly(styrene) Copolymers
Authors: Angelini Alessandro , Car Anja , Dinu Ionel Adrian , Leva Luigi , Yave Wilfredo 
Published: January 2023

AbstractTailor‐made poly(vinyl alcohol)‐b‐poly(styrene) copolymers (PVA‐b‐PS) for separation membranes are synthesized by the combination of reversible‐deactivation radical polymerization techniques. The special features of these di‐block copolymers are the high molecular weight (>70 kDa), the high PVA content (>80 wt%), and the good film‐forming property. They are soluble only in hot dimethyl sulfoxide, but by the “solvent‐switch” technique, they self‐assemble in aqueous media to form micelles. When the self‐assembled micelles are cast on a porous substrate, thin‐film membranes with higher water permeance than that of PVA homopolymer are obtained. Thus, by using these tailor‐made PVA‐b‐PS copolymers, it is demonstrated that chemical cross‐linkers and acid catalysts can no longer be needed to produce PVA membranes, since the PS nanodomains within the PVA matrix act as cross‐linking points. Lastly, subsequent thermal annealing of the thin film enhances the membrane selectivity due to the improved microphase separation.
Thyroid Disorders and Movement Disorders—A Systematic Review
Authors: Schneider Susanne A. , Tschaidse Lea , Reisch Nicole 
Published: January 2023

AbstractBackgroundThere is overlap between movement disorders and neuroendocrine abnormalities.Objectives and methodsTo provide a systematic review on the association of thyroid dysfunction and movement disorders. Thyroid physiological function and classical thyroid disorders highlighting typical and atypical manifestations including movement disorders, as well as diagnostic procedures, and treatments are discussed.ResultsHypothyroidism may be associated with hypokinetic and hyperkinetic disorders. There is debate whether their concomitance reflects a causal link, is coincidence, or the result of one unmasking the other. Hypothyroidism‐associated parkinsonism may resemble idiopathic Parkinson's disease. Hypothyroidism‐associated hyperkinetic disorders mainly occur in the context of steroid‐responsive encephalopathy with autoimmune thyroiditis, that is, Hashimoto disease, mostly manifesting with tremor, myoclonus, and ataxia present in 28–80%, 42–65% and 33–65% in larger series. Congenital hypothyroidism manifesting with movement disorders, mostly chorea and dystonia, due to Mendelian genetic disease are rare.Hyperthyroidism on the other hand mostly manifests with hyperkinetic movement disorders, typically tremor (present in three quarters of patients). Chorea (present in about 2% of hyperthyroid patients), dystonia, myoclonus, ataxia and paroxysmal movement disorders, as well as parkinsonism have also been reported, with correlation between movement intensity and thyroid hormone levels.On a group level, studies on the role of thyroid dysfunction as a risk factor for the development of PD remain non‐conclusive.ConclusionsIn view of the treatability of movement disorders associated with thyroid disease, accurate diagnosis is important. The pathophysiology remains poorly understood. More detailed case documentation and systematic studies, along with experimental studies are needed.
Change in medial frontal cerebral metabolite concentrations following bariatric surgery
Authors: Bottari Sarah A. , Cohen Ronald A. , Friedman Jeffrey , Porges Eric C. , Chen Alexa , Britton Mark K. , Gunstad John , Woods Adam J. , Williamson John B. 
Published: January 2023

AbstractObesity is associated with adverse effects on brain health, including an increased risk of neurodegenerative diseases. Changes in cerebral metabolism may underlie or precede structural and functional brain changes. While bariatric surgery is known to be effective in inducing weight loss and improving obesity‐related medical comorbidities, few studies have examined whether it may be able to improve brain metabolism. In the present study, we examined changes in cerebral metabolite concentrations in participants with obesity who underwent bariatric surgery. Thirty‐five patients with obesity (body mass index ≥ 35 kg/m2) were recruited from a bariatric surgery candidate nutrition class. They completed single voxel proton magnetic resonance spectroscopy at baseline (presurgery) and within 1 year postsurgery. Spectra were obtained from a large medial frontal brain region using a PRESS sequence on a 3‐T Siemens Verio scanner. The acquisition parameters were TR = 3000 ms and TE = 37 ms. Tissue‐corrected metabolite concentrations were determined using Osprey. Paired t‐tests were used to examine within‐subject change in metabolite concentrations, and correlations were used to relate these changes to other health‐related outcomes, including weight loss and glycated hemoglobin (HbA1c), a measure of blood sugar levels. Bariatric surgery was associated with a reduction in cerebral choline‐containing compounds (Cho; t [34] = − 3.79, p < 0.001, d = −0.64) and myo‐inositol (mI; t [34] = − 2.81, p < 0.01, d = −0.47) concentrations. There were no significant changes in N‐acetyl‐aspartate, creatine, or glutamate and glutamine concentrations. Reductions in Cho were associated with greater weight loss (r = 0.40, p < 0.05), and reductions in mI were associated with greater reductions in HbA1c (r = 0.44, p < 0.05). In conclusion, participants who underwent bariatric surgery exhibited reductions in cerebral Cho and mI concentrations, which were associated with improvements in weight loss and glycemic control. Given that elevated levels of Cho and mI have been implicated in neuroinflammation, reduction in these metabolites after bariatric surgery may reflect amelioration of obesity‐related neuroinflammatory processes. As such, our results provide evidence that bariatric surgery may improve brain health and metabolism in individuals with obesity.
Neighborhood deprivation and residential property values do not affect weight loss at 1 or 3 years after bariatric surgery
Authors: Drewnowski Adam , Hong Benjamin D. , Shen Ernest , Ji Ming , Paz Silvia R. , Bhakta Bhumi B. , Macias Mayra , Crawford Cecelia L. , Lewis Kristina H. , Liu Jialuo , Moore Darren D. , Murali Sameer B. , Young Deborah R. , Coleman Karen J. 
Published: January 2023

AbstractObjectiveThis study examined the association between individual‐ and neighborhood‐level sociodemographic factors and surgical weight loss at 1 year (short term) and 3 years (long term).MethodsData were obtained from the baseline survey of the BELONG (Bariatric Experience Long Term) prospective longitudinal cohort study. Individual‐level self‐reported data on sex, race and ethnicity, education, and household income were obtained by survey. Data from the 2010 US Census were used to calculate area Neighborhood Deprivation Index score and median value of owner‐occupied housing units at the census tract level.ResultsPatients (N = 1341) had a mean age of 43.4 (SD 11.3) years, were mostly female (86%), were mostly Black or Hispanic (52%), had some college education (83%), and had annual household incomes ≥$51,000 (55%). Percentage total weight loss was 25.8% (SD 9.0%) at year 1 and 22.2% (SD 10.5%) at year 3. Race and ethnicity and age were significant predictors of weight loss at 1 and 3 years with a small effect of self‐reported household income at year 1. There were no significant associations between census tract–level Neighborhood Deprivation Index score or value of owner‐occupied housing units and weight loss at either time point.ConclusionsHealth systems could improve the chances of weight‐loss maintenance after surgery by addressing factors related to racial and ethnic disparities and to income disparities.
Soil bacterial communities are influenced by soil chemical characteristics and dispersal limitation in commercial strawberry production systems
Authors: LeBlanc Nicholas , Gebben Samantha 
Published: January 2023

AbstractBacterial communities play multiple functional roles in soil that have positive and negative feedbacks on plant health. However, relatively few studies have focused on the ecology of soil bacterial communities in commercial strawberry production systems. The objective of this study was to determine if ecological processes influencing soil bacterial communities are consistent among commercial strawberry production locations and plots within the same geographic region. Soil samples were collected using a spatially explicit design from three plots in two commercial strawberry production locations in the Salinas Valley region of California. Soil carbon, nitrogen, and pH were measured for each of the 72 soil samples and bacterial communities were characterized using 16 S rRNA sequencing. Multivariate analyses showed bacterial community composition was differentiated between the two strawberry production locations. Analyses of communities within plots demonstrated soil pH and nitrogen were significant predictors of bacterial community composition in one of the three sampled plots. Bacterial communities displayed spatial structure in two plots at one location based on a significant increase in community dissimilarity with increasing spatial distance. Null model analyses identified a lack of phylogenetic turnover among bacterial communities in all plots, but a greater frequency of dispersal limitation in the two plots where spatial structure was also observed. Overall, this work suggests that ecological factors influencing soil bacterial communities are not consistent among different strawberry production locations or plots which may impact the ability to predict or manage the effect of soil microbiomes on strawberry health.
Injection overmolding of polymer‐metal hybrid structures: A review
Authors: Vasconcelos Rayana L. , Oliveira Gean H. M. , Amancio‐Filho Sergio T. , Canto Leonardo B. 
Published: January 2023

AbstractPolymer‐metal hybrid (PMH) structures, also known as metal‐polymer hybrid (MPH) structures, have received considerable attention from industry and academia due to the societal need for developing strong, lightweight, and durable structures for several applications in strategic areas, such as transportation, household appliances, energy, and biomedical devices. Injection overmolding is an advantageous technique for manufacturing PMH structures as it combines automation, a fast process, cost efficiency, and dimensional accuracy. This review presents a comprehensive discussion of recent advances reported in the literature concerning PMH structures fabricated by direct‐adhesion injection overmolding. Following a general introduction, the fundamentals of the injection overmolding technique are presented. Next, the potential of some metal surface preparation methods to ensure good adhesion, and thus outstanding mechanical performance in injection overmolded PMH structures is discussed. Correlations are then made between metal surface features, processing parameters, and the mechanical strength of injection overmolded polymer‐metal joints. Some applications of injection overmolded PMH structures are explored, and, lastly, the main conclusions and prospects on the use of injection overmolding are presented.
Fine‐tuning the backbone conformation of conjugated polymers and the influence on solution aggregation and optoelectronic properties
Authors: Liu Yi , Lu Yang , Ding Li , Pan Chen‐Kai , Xu Yu‐Chun , Wang Tian‐Yao , Wang Jie‐Yu , Pei Jian 
Published: January 2023

AbstractThe backbone conformation plays a vital role in the solution aggregation behavior and photophysical and electrical properties of conjugated polymers. Previous studies indicated that the backbone conformation modification mainly relied on introducing various functional groups. However, regulating the molecular conformation through non‐covalent interactions is highly susceptible to external factors such as solvents and temperature. Herein, four isoindigo‐based polymers, IIDDP, IIDDP‐C0, IIDDP‐C1, and IIDDP‐C2, are developed with distinct chain conformation. Covalent bonds are employed to fix the dihedral angle of the donor fragment and then control the main‐chain conformation. Due to conformation‐locking, it was observed that the planarization of the main chain from the solution to the thin film could not be achieved in the desired polymers with twisted backbones. Further investigations revealed that the relationship between the backbone conformation and the solution‐state supramolecular structures play a critical role in controlling solid‐state microstructures and optoelectronic performance of conjugated polymers.
Cytochrome P450s genes CYP321A9 and CYP9A58 contribute to host plant adaptation in the fall armyworm Spodoptera frugiperda
Authors: He Li , Shi Yang , Ding Wenbing , Huang Hong , He Hualiang , Xue Jin , Gao Qiao , Zhang Zhixiang , Li Youzhi , Qiu Lin 
Published: January 2023

AbstractBACKGROUNDThe fall armyworm, Spodoptera frugiperda is one of the most destructive agricultural pests, which can complete their entire life cycle on various plants. At present, some detoxification genes have been proved to be involved in the adaptability to plants in insects. However, the genetics behind insect pest responses to host switches, and their ability to adapt to new host plants, remain poorly understood. This study was conducted to evaluate the adaptation of S. frugiperda to host plant and determine the roles of CYP321A9 and CYP9A58 in the detoxification metabolism of the fall armyworm.RESULTSThe results revealed that feeding on maize was more suitable for S. frugiperda to develop compared with rice. In addition, knocking down of SfCYP321A9 and SfCYP9A58 resulted in a prolonged developmental time of S. frugiperda larvae that fed on rice. Meanwhile, RNAi knockdown of SfCYP321A9 resulted in significantly higher mortality of S. frugiperda larvae when exposed to the rice allelochemicals, ferulic acid, gramine and tricin. Furthermore, overexpression of SfCYP321A9 significantly reduced mortality in Drosophila melanogaster when exposed to gramine and tricin.CONCLUSIONOur results suggest that CYP321A9 and CYP9A58 genes play a key role in host plant adaptation in S. frugiperda, which contribute to a greater understanding of the molecular basis of host plant adaptation and provide the means to develop effective management tools for S. frugiperda resistance. © 2023 Society of Chemical Industry.
An autonomous ground robot to support firefighters' interventions in indoor emergencies
Authors: Talavera N. Fernández , Roldán‐Gómez Juan Jesús , Martín Francisco , Rodriguez‐Sanchez M. C. 
Published: January 2023

AbstractIntervention teams act in hostile scenarios where reducing mission times and accident risks is critical. In these situations, the availability of accurate information about the environment plays a key role in ensuring the well‐being of rescuers and victims. This information required to plan the interventions in indoor emergencies encompasses the location of fires and the presence of dangerous gases. Robotics and remote sensing technologies can help emergency teams to obtain this information in real‐time without exposing themselves. Additionally, the accurate simulation of the environments allows the teams to plan their interventions, creating routes to safely access the affected areas and evacuate the victims. This article presents a robotic solution developed to satisfy the demands of intervention teams. More specifically, it describes an autonomous ground robot that can obtain real‐time location and environmental data from indoor fires, as well as a simulator that reproduces these emergency scenarios and facilitates mission planning. In this way, emergency teams can know the conditions in the scenario before, during, and after the intervention. Thus, risks are minimized by improving their situational awareness and reducing their exposure times during the mission. The system has been developed and validated in collaboration with the end‐users and under realistic harsh environments. During these experiments, the robot was used to detect fire sources and cold smoke and provide environmental information to firefighters. Additionally, the simulator provided alternative routes for accessing and exiting the scene faster and safer by dodging potentially dangerous areas.