bluuebunny/crossref_metadata_2025_split huggingface dataset:
Similarity based position calibration for multisource track inspection data
Authors: Ma Shuai , Liu Xiubo , Zhang Bo , Qiang Weile , Wei Jianmei 
Published: March 2023

Track geometry inspection data have long endured positional errors and shifts, hindering the quality evaluation, deterioration analysis and maintenance work of railway track. Besides, vehicle response inspection data are also typically misaligned or shifted from each other, but it tends to be ignored by people. In light of this situation, a position calibration method on the basis of a simple similarity metric, i.e. correlation coefficient, is proposed to tackle the positional errors and shifts among multisource track inspection data concurrently. For the convenience of practical implementation, a scheme containing three parts is designed to fulfil the purpose and a two-step procedure is adopted by all the three parts. According to the performance test on a dataset containing five inspection runs of a high-speed railway in China, the positional error between inspection data and actual locations can be greatly diminished, and the data inspected at different times and from different sources are well aligned with each other, with a time consumption of 0.66 s on average for a 1 km segment.
Antibiotic Treatment in End Stage Cancer Patients; Advantages and Disadvantages
Authors: Mamak Tahmasebi , Hadiseh Hosamirudsari , Shirin Familrashtian , Masoud Parash , Mohammadreza Salehi , Mahsa Abbaszadeh 
Published: March 2023

Aim: In this study our aim was to elucidate whether advanced cancer patients benefit from antibiotic treatment in the last days of life in addition to reviewing the relevant costs and effects. Materials And Methods: We reviewed medical records from 100 end-stage cancer patients and their antibiotic use during the hospitalization in Imam Khomeini hospital. Patient’s medical records were analyzed retrospectively for cause and periodicity of infections, fever, increase in acute phase proteins, cultures, type and cost of antibiotic. Results: Microorganisms were found in only 29 patients (29%) and the most microorganism among the patients was E. coli (6%). About 78% of the patients had clinical symptoms. The highest dose of antibiotics was related to Ceftriaxone (40.2%) and in the second place was Metronidazole (34.7%) and the lowest dose was related to Levofloxacin, Gentamycin and Colistin (1.4%). Fifty-one patients (71%) did not have any side effects due to antibiotics. The most common side effect of antibiotics among patients was skin rash (12.5%). The average estimated cost for antibiotic use was 7 935 540 Rials (24.4 dollars). Conclusion: Prescription of antibiotics was not effective in symptom control in advanced cancer patients. The cost of using antibiotics during hospitalization is very high and also the risk of developing resistant pathogens during admission should be considered. Antibiotic side effects also occur in patients, causing more harm to the patient at the end of life. Therefore, the benefits of antibiotic advice in this time is less than its negative effects.
The credibility of subgroup analyses reported in stroke trials is low: A systematic review
Authors: Ademola Ayoola , Thabane Lehana , Adekanye Joel , Okikiolu Ayooluwanimi , Babatunde Samuel , Almekhlafi Mohammed A , Menon Bijoy K , Hill Michael D , Hildebrand Kevin A , Sajobi Tolulope T 
Published: March 2023

Background: Subgroup analyses are widely used to evaluate the heterogeneity of treatment effects in randomized clinical trials. However, there is a limited investigation of the quality of prespecified and reported subgroup analyses in stroke trials. This study evaluated the credibility of subgroup analyses in stroke trials. Methods and analysis: We searched Medline/PubMed, Embase, the Cochrane Central Register of Controlled Trials, and the Web of Science from inception to 24 March 2021. Three reviewers screened, extracted, and analyzed the data from the publications. Primary publications of stroke trials that reported at least one subgroup effect and had published corresponding study protocols were included. The Instrument for Assessing the Credibility of Effect Modification Analyses (ICEMAN) was used to examine the quality of the subgroup effects reported, with each subgroup effect assigned a credibility rating ranging from very low to high. Subgroup effects with two or more “definitely no” responses received a low credibility rating. The risk of bias was assessed using the Cochrane Risk-of-Bias tool for randomized trials version 2. Results: Seventy-four articles met the inclusion criteria and reported a combined total of 647 subgroup effects. The median sample size was 1264 (interquartile range (IQR): 380–3876), and the median number of subgroups prespecified in the protocol was 6 (IQR: 2–10). Sixty-one (82%) studies used the univariate test of interaction. Of the total 647 subgroup effects reported in these studies, 319 (49%) were reported in acute stroke trials, while 423 (65%) had low credibility. Conclusion: The quality of subgroup analysis reporting in stroke trials remains poor. More effort is needed to train trialists on the best methods for designing and performing subgroup analyses, and how to report the results. Trial registration number: We prospectively registered the review with International Prospective Register for Systematic Reviews (registration number: CRD42020223133)
Clinical Outcomes After ACL Reconstruction in Soccer (Football, Futbol) Players: A Systematic Review and Meta-Analysis
Authors: Hong Ian S. , Pierpoint Lauren A. , Hellwinkel Justin E. , Berk Alexander N. , Salandra Jonathan M. , Meade Joshua D. , Piasecki Dana P. , Fleischli James E. , Ahmad Christopher S. , Trofa David P. , Saltzman Bryan M. 
Published: March 2023

Context: The risk factors for anterior cruciate ligament (ACL) tear for athletes participating in pivoting sports includes young age and female sex. A previous meta-analysis has reported a reinjury rate of 15% after ACL reconstruction (ACLR) for athletes across all sports. To the best of the authors’ knowledge, this is the first systematic review and meta-analysis of available literature reporting outcomes after ACLR in soccer players. Objective: To review and aggregate soccer-specific outcomes data after ACLR found in current literature to help guide a more tailored discussion regarding expectations and prognosis for soccer players seeking operative management of ACL injuries. Data Sources: A comprehensive search of publications was performed using PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and SPORTDiscus databases. Study Selection: Inclusion criteria consisted of original studies, level of evidence 1 to 4, studies reporting clinical and patient-reported outcomes (PROs) after primary ACLR in soccer players at all follow-up length. Study Design: The primary outcomes of interest were graft failure/reoperation rates, ACL injury in contralateral knee, return to soccer time, and PROs. Level of Evidence: Level 4. Data Extraction: Search of literature yielded 32 studies for inclusion that involved 3112 soccer players after ACLR. Results: The overall graft failure/reoperation rate ranged between 3.0% and 24.8% (mean follow-up range, 2.3-10 years) and the combined ACL graft failure and contralateral ACL injury rate after initial ACLR was 1.0% to 16.7% (mean follow-up range, 3-10 years); a subgroup analysis for female and male players revealed a secondary ACL injury incidence rate of 27%, 95% CI (22%, 32%) and 10%, 95% CI (6%, 15%), respectively. Soccer players were able to return to play between 6.1 and 11.1 months and the majority of PROs showed favorable scores at medium-term follow-up. Conclusion: Soccer players experience high ACL injury rates after primary ACLR and demonstrated similar reinjury rates as found in previous literature of athletes who participate in high-demand pivoting sports.
Opportunities, associations, and impact of early intravenous to oral antimicrobial switch for hospitalized patients in Ethiopia
Authors: Tefera Gosaye Mekonen , Sileshi Tesemma , Mekete Mekonnen Derese , Umeta Gurmu Tesfaye 
Published: March 2023

Objective: Short intravenous antimicrobial therapy for 2–3 days followed by its per oral comparable antimicrobial course is a crucial part of the antimicrobial stewardship program. However, nothing is known about this practice in Ethiopian hospitals. Therefore, this study assessed the proportion, associations, and outcomes of early intravenous to per oral antimicrobial switch for patients who were admitted to the three wards of Ambo University Referral Hospital. Method: A hospital-based prospective cohort pilot study was conducted. During the 3-month period, 117 patients met initial inclusion criteria and were followed until Day 3 of intravenous antimicrobial. Of these, 92 (78.6%) subsequently met criteria for early intravenous to per oral switch and are the cohort investigated in this study. Written informed consent was sought from participants and/or parents or guardian for ages 15–17 years. Logistic regression models and independent t-tests were done with a significance of p ⩽ 0.05. Results: Out of 92 study participants, early intravenous to per oral antimicrobial switch was done only for 36 (39.1%). The only independent predictors for lack of early intravenous to per oral antimicrobials switch were poly-pharmacy (adjusted odds ratio = 3.4 at 95% confidence interval, 1.036–11.16; p = 0.044). There was a significant difference in terms of mean length of hospital stay (8.80 ± 3.57 versus 3.17 ± 0.74; p < 0.0001), in-hospital complication rate (95% versus 5%; p < 0.0001), and the mean cost of healthcare in Ethiopian Birrs (652.29 ± 403.29 versus 126.67 ± 29.47; p < 0.0001) between the comparator/early intravenous to per oral not switched and early switched group, respectively. Conclusion: The proportion of early intravenous to per oral antimicrobial switch was unsatisfactory. There was a significant difference between the intervention and comparator groups in terms of length of hospital stay, in-hospital complications, and extra cost. Therefore, implementation of interventions that improve the practice of early intravenous to per oral switch is needed urgently.
Using shoe-mounted inertial sensors and stepping exergames to assess the motor-cognitive status of older adults: A correlational study
Authors: Guimarães Vânia , Sousa Inês , Bruin Eling D. de , Pais Joana , Correia Miguel Velhote 
Published: March 2023

Objective Stepping exergames designed to stimulate physical and cognitive skills can provide important information concerning individuals’ performance. In this study, we investigated the potential of stepping and gameplay metrics to assess the motor-cognitive status of older adults. Methods Stepping and gameplay metrics were recorded in a longitudinal study involving 13 older adults with mobility limitations. Game parameters included games’ scores and reaction times. Stepping parameters included length, height, speed, and duration, measured by inertial sensors placed on the shoes while interacting with the exergames. Parameters measured on the first gameplay were correlated against standard cognitive and mobility assessments, including the Montreal Cognitive Assessment (MoCA), gait speed, and the Short Physical Performance Battery. Based on MoCA scores, patients were then stratified into two groups: cognitively impaired and healthy controls. The differences between the two groups were visually inspected, considering their within-game progression over the training period. Results Stepping and gameplay metrics had moderate-to-strong correlations with cognitive and mobility performance indicators: faster, longer, and higher steps were associated with better mobility scores; better cognitive games’ scores and reaction times, and longer and faster steps were associated with better cognitive performance. The preliminary visual analysis revealed that the group with cognitive impairment required more time to advance to the next difficulty level, also presenting slower reaction times and stepping speeds when compared to the healthy control group. Conclusion Stepping exergames may be useful for assessing the cognitive and motor status of older adults, potentially allowing assessments to be more frequent, affordable, and enjoyable. Further research is required to confirm results in the long term using a larger and more diverse sample.
Paper 03: Suprascapular Neuropathy: Two Distinct Presentations and Outcomes of Decompression
Authors: McCarthy Conor , Bishop Kristen , Kirby Hannah , Susmarski Adam , Dickens Jonathan , Kilcoyne Kelly , LeClere Lance 
Published: March 2023

Objectives: Suprascapular neuropathy due to nerve compression or tension at the suprascapular notch is an uncommon source of shoulder pain and rotator cuff weakness with recent increased recognition and treatment. Long considered an elusive diagnosis, work-up can be lengthy and patients may experience treatment delay. We aimed to review presentation patterns and outcomes of arthroscopic suprascapular nerve decompression in a predominantly young and active military population. Methods: The surgical databases of two surgeons were queried for patients treated with arthroscopic suprascapular nerve decompression at the suprascapular notch from 2013 to 2021. Patient data, presentation and workup findings, and outcome measures were collected through review of the electronic medical record. Primary outcome measures were rate of return to active-duty military service, shoulder abduction and external rotation strength, and VAS pain scores. Secondary outcome measures were American Shoulder and Elbow Surgeons (ASES) Shoulder Score, Visual Analogue Scale (VAS), and Single Assessment Numerical Evaluation (SANE) score. Results: Twenty-five patients were identified. Average age was 26.6 years and follow-up 17.9 months (4-62 months). There were two distinct primary presentation types in this cohort: the chief complaint was pain in 13 patients (52%) and weakness in 12 (48%). Supraspinatus and/or infraspinatus atrophy was present on MRI in 10/12 patients with weakness and 0/13 with pain. Electromyography was positive in 9/12 with weakness and negative when obtained in 5 patients with pain. Ultrasound-guided suprascapular nerve injection was performed in 10/13 with pain and provided mean 91% symptom relief. Patients with pain had longer duration of pre-operative symptoms (22.2 [±13.1] vs. 10.3 [±13.6] weeks). Postoperatively, the pain group had significant improvement in VAS scores (6.2 [±1.6] to 1.0 [±0.9]), while the weakness group had significant improvement in abduction and external rotation motor grading (3.7 [±0.7] to 4.7 [±0.4] and 3.3 [±0.8] to 4.4 [±0.6] respectively). Return to duty or sport was 92% at a mean of 14.6 (±9.3) weeks. Conclusions: In this young, active cohort, suprascapular neuropathy presented with one of two distinct primary presenting complaints: pain or weakness. Given different expected work-up findings, categorizing patients into one of these two groups may be beneficial in effectively diagnosing and treating suprascapular neuropathy. Outcomes after arthroscopic suprascapular nerve release at the suprascapular notch predictably led to successful pain relief and strength improvement in patients presenting with pain and weakness respectively. [Table: see text][Table: see text]
Paper 07: The True Learning Curve in Hip Arthroscopy According to Patient-Reported Outcomes
Authors: Westermann Robert 
Published: March 2023

Objectives: Arthroscopic correction of FAI is a powerful way to improve pain and function in athletes and patients. Surgeons learning hip arthroscopy experience a learning curve while gaining competence. The objective of the present study was to evaluate the learning curve in hip arthroscopy for FAI according to improvements in patient-reported outcome instruments. Methods: A retrospective review was performed of a single surgeon’s first 1000 hip arthroscopy cases during their first 4 years in practice. Arthroscopy cases that occurred concurrently with PAO or femoral osteotomy (n=360) were excluded. Convenience samples (n=50) were taken from each year in practice. Pre-operative and post-operative HOOS- Pain and HOOS-physical function scores were obtained. Linear trends were assessed, and cutoffs for MCID for HOOS (10 points) were surveyed across time. Students t tests were used for continuous variables and chi squared tests were used for categorical variables and significance was set to p<0.05. Results: During the first 250 cases, a sample of patients was obtained (n=50), and 11/50 did not meet MCID (22%) for HOOS Pain at 1-year follow-up. A convenience sample of cases subsequent to this from cases 251-1000 (n=100) 11/100 after that did not meet MCID (11.0%, p<0.05). The mean 1-year postop HOOS Pain score for year 1 was 82.77, year 2 was 90.56, year 3 was 89.34 and year 4 was 93.48 (P<0.05). Delta HOOS Pain of PS did not change over time, p>0.05). For both HOOS Pain and Physical Function subscales, 1-year postop scores continued to improve over the 4-year 1000-case study period (graph). Conclusions: According to the HOOS validated patient reported outcome instrument, the learning curve for significant benefits in hip arthroscopy is between 130-250 cases. Many patients (almost 80%) saw significant clinical benefit during the learning curve, however the quality of outcome was significantly improved after 250 cases. 1-year post-op PROs appear to continually improve even after cases 750-1000
Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms
Authors: Nannya Yasuhito , Tobiasson Magnus , Sato Shinya , Bernard Elsa , Ohtake Shigeki , Takeda June , Creignou Maria , Zhao Lanying , Kusakabe Manabu , Shibata Yuhei , Nakamura Nobuhiko , Watanabe Mizuki , Hiramoto Nobuhiro , Shiozawa Yusuke , Shiraishi Yuichi , Tanaka Hiroko , Yoshida Kenichi , Kakiuchi Nobuyuki , Makishima Hideki , Nakagawa Masahiro , Usuki Kensuke , Watanabe Mitsumasa , Imada Kazunori , Handa Hiroshi , Taguchi Masataka , Kiguchi Toru , Ohyashiki Kazuma , Ishikawa Takayuki , Takaori-Kondo Akifumi , Tsurumi Hisashi , Kasahara Senji , Chiba Shigeru , Naoe Tomoki , Miyano Satoru , Papaemanuil Elli , Miyazaki Yasushi , Hellström-Lindberg Eva , Ogawa Seishi 
Published: March 2023

Abstract
Azacitidine is a mainstay of therapy for myelodysplastic syndrome (MDS)–related diseases. The purpose of our study is to elucidate the effect of gene mutations on hematological response and overall survival (OS), particularly focusing on their posttreatment clone size. We enrolled a total of 449 patients with MDS or related myeloid neoplasms. They were analyzed for gene mutations in pretreatment (n = 449) and posttreatment (n = 289) bone marrow samples using targeted-capture sequencing to assess the impact of gene mutations and their posttreatment clone size on treatment outcomes. In Cox proportional hazard modeling, multihit TP53 mutation (hazard ratio [HR], 2.03; 95% confidence interval [CI], 1.42-2.91; P &lt; .001), EZH2 mutation (HR, 1.71; 95% CI, 1.14-2.54; P = .009), and DDX41 mutation (HR, 0.33; 95% CI, 0.17-0.62; P &lt; .001), together with age, high-risk karyotypes, low platelets, and high blast counts, independently predicted OS. Posttreatment clone size accounting for all drivers significantly correlated with International Working Group (IWG) response (P &lt; .001, using trend test), except for that of DDX41-mutated clones, which did not predict IWG response. Combined, IWG response and posttreatment clone size further improved the prediction of the original model and even that of a recently proposed molecular prediction model, the molecular International Prognostic Scoring System (IPSS-M; c-index, 0.653 vs 0.688; P &lt; .001, using likelihood ratio test). In conclusion, evaluation of posttreatment clone size, together with the pretreatment mutational profile as well as the IWG response play a role in better prognostication of azacitidine-treated patients with myelodysplasia.
Assessment of malnutrition-related risk in patients with idiopathic pleuroparenchymal fibroelastosis
Authors: Suzuki Yuzo , Fukada Atsuki , Mori Kazutaka , Kono Masato , Hasegawa Hirotsugu , Hashimoto Dai , Yokomura Koshi , Imokawa Shiro , Inoue Yusuke , Yasui Hideki , Hozumi Hironao , Karayama Masato , Furuhashi Kazuki , Enomoto Noriyuki , Fujisawa Tomoyuki , Inui Naoki , Nakamura Hidenori , Suda Takafumi 
Published: March 2023

BackgroundIdiopathic pleuroparenchymal fibroelastosis (IPPFE) is characterised by upper lobe-dominant fibrosis involving the pleura and subpleural lung parenchyma, with advanced cases often complicated by progressive weight loss. Therefore, we hypothesised that nutritional status is associated with mortality in IPPFE.MethodsThis retrospective study assesses nutritional status at the time of diagnosis and 1 year after diagnosis in 131 patients with IPPFE. Malnutrition-related risk was evaluated using the Geriatric Nutritional Risk Index (GNRI).ResultsOf the 131 patients, 96 (73.8%) were at malnutrition-related risk at the time of diagnosis according to the GNRI. Of these, 21 patients (16.0%) were classified as at major malnutrition-related risk (GNRI <82). Patients at major malnutrition-related risk were significantly older and had worse pulmonary function than patients at low (GNRI 92– <98) and moderate (GNRI 82– <92) malnutrition-related risk. GNRI scores decreased significantly from the time of diagnosis to 1 year after diagnosis. Patients with a lower GNRI (<91.8) had significantly shorter survival than patients with a median GNRI or higher (≥91.8). Patients with declines in annual GNRI scores of ≥5 had significantly shorter survival than patients with declines in annual GNRI scores of <5. In multivariate analysis, major malnutrition-related risk was significantly associated with increased mortality after adjustment for age, sex and forced vital capacity (hazard ratio 1.957). A composite scoring model including age, sex and major malnutrition-related risk was able to separate mortality risk in IPPFE.ConclusionAssessment of nutritional status by the GNRI provides useful information for managing patients with IPPFE by predicting mortality risk.
Do not discount the diagnosis of VKH based on race: self-reported race and ethnicity of patients with Vogt-Koyanagi-Harada disease in a predominantly white population
Authors: Deák Gábor Gy. , Koreishi Anjum F. , Goldstein Debra A. 
Published: March 2023

Abstract
Background
We examined the racial and ethnic distribution of patients with Vogt-Koyanagi-Harada disease (VKH) in a Midwestern US population through a retrospective chart review of patients with VKH seen in a tertiary referral centre between 2012 and 2017. All patients were diagnosed by one uveitis specialist (DAG). We identified 32 patients with VKH seen during this time period. The mean age at diagnosis was 37.7 ± 15.7 years, 7 were male, 25 female. Mean follow-up was 36.7 ± 21.7 months. Nine patients reported themselves as White non-Hispanic, (28.1%), 9 as Black/African-American (28.1%), 2 as Asian (6.3%) and 9 as Hispanic or Latino (28.1%). Three patients (9.4%) were of Middle-Eastern origin. The 2010 census results for race and ethnicity in the state of Illinois were: 71.5% White, 14.5% Black/African-American, 4.6% Asian, and 6.7% as Some Other Race. From the total population 15.8% reported themselves as Hispanic or Latino (of any race).

Conclusions
VKH was much more frequent among white non-Hispanic patients (28.1%) and Black/African-American patients (28.1%) in our patient population than in previous reports from the US (3–14% and 4–23% respectively). While Hispanic patients in this series were over represented in the VKH population compared with the overall census data, the percentage of VKH patients in this series who were White non-Hispanic and Hispanic was the same. The diagnosis of VKH should be considered in any patient with the appropriate clinical features, regardless of race or ethnicity.