bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing anti‐meltdrop and smoke suppression properties of flame retardant poly(ethylene terephthalate) fabric by fiber‐blending method
Authors: Liang Shuheng , Xie Qibao , Xu Qibin , Sun Zhaomei , Liu Yuying , Jiang Xijiong , Liu Pengqing , Jiang Mengjin 
Published: April 2023

AbstractFlame retardant poly(ethylene terephthalate) (FRPET) fabrics are widely used in daily life. However, the meltdrop and visible smoke produced during combustion significantly limit its further application. This study proposes a simple but effective method of fiber‐blending to improve the above shortcomings. On the basis of synergistic flame retardancy of nitrogen and phosphorus, the FRPET was blended with flame retardant viscose (FRV) and intrinsic nitrogen‐containing flame retardant fibers (NIFRFs), to prepare the binary and ternary blended FRPET samples labeled as NIFRF/FRPET and FRV/NIFRF/FRPET, respectively. The limiting oxygen index and cone calorimeter test show that the ternary‐blending could effectively suppress the combustion of FRPET fiber composite. The smoke density test and UL‐94 vertical combustion test indicate that ternary‐blending could better improve the meltdrop characteristics and smoke suppression property than binary‐blending. Among all samples, FRV/PMIA/FRPET (1:4:5) owns the highest LOI of 32.6% and lowest smoke density of 61.37. The investigation of residual char utilizing scanning electron microscopy, the X‐ray photoelectron spectroscopy and the Laser Raman spectroscopy demonstrates that the FRPET meltdrop would adhere to the surface of component fibers to avoid droplets. Besides, fiber‐blending could increase the yield and degree of graphitization of residual char, which is conducive to improving samples' flame retardancy through the condensed phase. This work may provide a workable strategy to expand the application areas of FRPET fabrics.
Effect of triethylene glycol bis(3‐tert‐butyl‐4‐hydroxy‐5‐methylphenyl)propionate on structure and mechanical properties of nitrile butadiene rubber/clay nanocomposites
Authors: Li Jian , Chen Shule , Zhang Xiaoming , Liu Xin , Chen Zilong , Lin Jun , He Shaojian 
Published: April 2023

AbstractClay modification by organic ammonium salts has been widely introduced in rubber/clay nanocomposites, but it is inapplicable in the polar rubbers to achieve high performance due to bad dispersion and poor compatibility. In this work, gel‐compounding method was utilized to prepare nitrile butadiene rubber (NBR)/clay nanocomposite, and then a hindered phenol antioxidant, triethylene glycol bis(3‐tert‐butyl‐4‐hydroxy‐5‐methylphenyl)propionate (AO‐245) with various contents, was mechanically blended to enhance the interactions in the nanocomposites. The elongation at break increases while the Shore A hardness, permanent set and stress at 100% or 300% strain decrease by adding AO‐245 into the nanocomposites. By adding only 5 phr AO‐245 in the nanocomposite, the tensile strength and elongation at break increased from 18.3 MPa and 521% to 20.5 MPa and 646%, respectively, which resulted from the repeated destruction/construction of the hydrogen bonds between AO‐245 and NBR. At high AO‐245 content, both clay networks and AO‐245 aggregate networks coexist in the nanocomposite, and the excess AO‐245 in the NBR matrix can form a separated phase leading to a new internal friction peak.
Alcohol Consumption and Risk of Total Hip Replacement Due to Hip Osteoarthritis in Women
Authors: Marchand Nathalie E. , Hu Yang , Song Mingyang , Rosner Bernard A. , Karlson Elizabeth W. , Ratzlaff Charles , Lu Bing , Liang Matthew H. , Willett Walter C. 
Published: April 2023

ObjectiveThis study was undertaken to examine the relationship between alcohol consumption and hip osteoarthritis in women. Alcohol has been associated with both adverse and beneficial health effects generally; however, the relationship between alcohol consumption and hip osteoarthritis has been minimally studied.MethodsAmong women in the Nurses’ Health Study cohort in the US, alcohol consumption was assessed every 4 years, starting in 1980. Intake was computed as cumulative averages and simple updates with latency periods of 0–4 through 20–24 years. We followed 83,383 women without diagnosed osteoarthritis in 1988 to June 2012. We identified 1,796 cases of total hip replacement due to hip osteoarthritis defined by self‐report of osteoarthritis with hip replacement.ResultsAlcohol consumption was positively associated with hip osteoarthritis risk. Compared with nondrinkers, multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) were HR 1.04 (95% CI 0.90, 1.19) for drinkers of >0 to <5 grams/day, HR 1.12 (95% CI 0.94, 1.33) for 5 to <10 grams/day, HR 1.31 (95% CI 1.10, 1.56) for 10 to <20 grams/day, and HR 1.34 (95% CI 1.09, 1.64) for ≥20 grams/day (P for trend < 0.0001). This association held in latency analyses of up to 16–20 years, and for alcohol consumption between 35–40 years of age. Independent of other alcoholic beverages, the multivariable HRs (per 10 grams of alcohol) were similar for individual types of alcohol intake (wine, liquor, and beer; P = 0.57 for heterogeneity among alcohol types).ConclusionHigher alcohol consumption was associated with greater incidence of total hip replacement due to hip osteoarthritis in a dose‐dependent manner in women.
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Multi‐objective optimization models for the renewal planning of multiple asset classes
Authors: Chen Thomas Ying‐Jeh , Wang Eric , Pasch Nicole , Ganjidoost Amin 
Published: April 2023

AbstractManaging the aging infrastructure of water distribution systems presents a challenge for many utilities. With various asset types competing for limited dollars, designing an effective asset management program is a resource allocation problem. Mobilization of equipment and crew is a significant cost (typically 2%–10%) within any capital improvement program. Therefore, selecting projects that target multiple asset classes together can reduce mobilization and help utilities stretch their budgets further. This research presents a process for modeling the joint renewal planning of multiple asset classes. The problem is framed as a dual‐objective optimization, where the selection of project areas aims to maximize lead service line removal and water meter changeout together. A case study from a Midwest utility is presented, and empirical data suggests the dual‐objective approach effectively reduces duplicate interventions in the same regions. Equity considerations are also examined, where constraints are added to enforce system‐wide project selection. Results show that the sensitivity of the objective toward equity is dependent on the underlying spatial distribution of the target asset itself, where uneven spread of the target asset leads to greater negative impact on model performance.
Teaching self‐control to reduce overt food stealing by children with autism and developmental disorders
Authors: Zhou Liming , Hu Xiaoyi , Zhai Yuxin , Zhang Geyi , Wang Xin 
Published: April 2023

AbstractFood stealing is often a serious behavioral problem among children with diagnoses of autism and other developmental disorders. Very few empirical studies concerning this behavioral challenge have been reported. We applied a correspondence training procedure to teach self‐control as replacement behavior to four children with autism and developmental disorders who displayed food stealing in the community. A changing criterion design embedded within a nonconcurrent multiple‐probe across participants design was used. The treatment succeeded for all four participants by increasing latency to eating highly preferred food to a predetermined criterion and reducing occurrences of food stealing to zero. Three participants generalized the replacement behavior to natural settings and maintained the behavior for 2 weeks, 1 month, 2 months, 3 months, and 4 months. One participant without expressive language was taught successfully during treatment trials but failed to maintain and generalize the behavior. A functional relation between delaying food eating and Say‐Do correspondence training was demonstrated.
LC‐HRMS Profiling and Phenolic Content, Cholinesterase, and Antioxidant Activities of Terminalia citrina
Authors: Özler Ebubekir , Topal Fevzi , Topal Meryem , Öztürk Sarıkaya Sevim Beyza 
Published: April 2023

AbstractTerminalia citrina (T. citrina) belongs to the Combretaceae family and is included in the class of medicinal plants in tropical countries such as Bangladesh, Myanmar, and India. The antioxidant activities of lyophilized water (WTE) and alcohol extracts (ETE) of T. citrina fruits, their phenolic content by LC‐HRMS, and their effects on cholinesterases (ChEs; AChE, acetylcholinesterase, and BChE, butyrylcholinesterase) were investigated. Especially ten different analytical methods were applied to determine the antioxidant capacity. Compared with similar studies for natural products in the literature, it was determined that both WTE and ETE exhibited strong antioxidant capacity. Syringe and ellagic acids were higher than other acids in ETE and WTE. IC50 values for ETE and WTE in DPPH radical and ABTS⋅+ scavenging activities were calculated as 1.69–1.68 μg mL−1 and 6.79–5.78 μg mL−1, respectively. The results of the biological investigations showed that ETE and WTE had an inhibition effect against ChEs, with IC50 values of 94.87 and 130.90 mg mL−1 for AChE and 262.55 and 279.70 mg mL−1 for BChE, respectively. These findings indicate that with the prominence of herbal treatments, T. citrina plant may guide the literature in treating Alzheimer's Disease, preventing oxidative damage, and mitochondrial dysfunction.
Daily allergy burden and heart rate characteristics in adults with allergic rhinitis based on a wearable telemonitoring system
Authors: Buekers Joren , Stas Michiel , Aerts Raf , Bruffaerts Nicolas , Dujardin Sebastien , Van Nieuwenhuyse An , Van Orshoven Jos , Chevance Guillaume , Somers Ben , Aerts Jean‐Marie , Garcia‐Aymerich Judith 
Published: April 2023

AbstractBackgroundAllergic rhinitis includes a certain degree of autonomic imbalance. However, no information is available on how daily changes in allergy burden affect autonomic imbalance. We aimed to estimate associations between daily allergy burden (allergy symptoms and mood) and daily heart rate characteristics (resting heart rate and sample entropy, both biomarkers of autonomic balance) of adults with allergic rhinitis, based on real‐world measurements with a wearable telemonitoring system.MethodsAdults with a tree pollen allergy used a smartphone application to self‐report daily allergy symptoms (score 0–44) and mood (score 0–4), and a Mio Alpha 2 wristwatch to collect heart rate characteristics during two pollen seasons of hazel, alder and birch in Belgium. Associations between daily allergy burden and heart rate characteristics were estimated using linear mixed effects distributed lag models with a random intercept for individuals and adjusted for potential confounders.ResultsAnalyses included 2497 participant‐days of 72 participants. A one‐point increase in allergy symptom score was associated with an increase in next‐day resting heart rate of 0.08 (95% CI: 0.02–0.15) beats per minute. A one‐point increase in mood score was associated with an increase in same‐day sample entropy of 0.80 (95% CI: 0.34–1.26) × 10−2. No associations were found between allergy symptoms and heart rate sample entropy, nor between mood and resting heart rate.ConclusionDaily repeated measurements with a wearable telemonitoring system revealed that the daily allergy burden of adults with allergic rhinitis has systemic effects beyond merely the respiratory system.
Utility ofCYP2D6copy number variants as prognostic biomarker in localized anal squamous cell carcinoma
Authors: Trilla‐Fuertes Lucía , Gámez‐Pozo Angelo , Nogué Miguel , Busquier Isabel , Arias Fernando , López‐Campos Fernando , Fernández‐Montes Ana , Ruiz Ana , Velázquez Concepción , Martín‐Bravo Celia , Pérez‐Ruiz Elisabeth , Asensio Elena , Hernández‐Yagüe Xavier , Rodrigues Aline , Ghanem Ismael , López‐Vacas Rocío , Hafez Ahmed , Arias Pedro , Dapía Irene , Solís Mario , Dittmann Antje , Ramos Ricardo , Llorens Carlos , Maurel Joan , Campos‐Barros Ángel , Fresno Vara Juan Ángel , Feliu Jaime 
Published: April 2023

AbstractBackgroundAnal squamous cell carcinoma (ASCC) is an infrequent tumor whose treatment has not changed since the 1970s. The aim of this study is the identification of biomarkers allowing personalized treatments and improvement of therapeutic outcomes.MethodsForty‐six paraffin tumor samples from ASCC patients were analyzed by whole‐exome sequencing. Copy number variants (CNVs) were identified and their relation to disease‐free survival (DFS) was studied and validated in an independent retrospective cohort of 101 ASCC patients from the Multidisciplinary Spanish Digestive Cancer Group (GEMCAD). GEMCAD cohort proteomics allowed assessing the biological features of these tumors.ResultsOn the discovery cohort, the median age was 61 years old, 50% were males, stages I/II/III: 3 (7%)/16 (35%)/27 (58%), respectively, median DFS was 33 months, and overall survival was 45 months. Twenty‐nine genes whose duplication was related to DFS were identified. The most representative was duplications of the CYP2D locus, includingCYP2D6,CYP2D7P, andCYP2D8Pgenes. Patients withCYP2D6CNV had worse DFS at 5 years than those with twoCYP2D6copies (21% vs. 84%;p < .0002, hazard ratio [HR], 5.8; 95% confidence interval [CI], 2.7–24.9). In the GEMCAD validation cohort, patients withCYP2D6CNV also had worse DFS at 5 years (56% vs. 87%;p = .02, HR = 3.6; 95% CI, 1.1–5.7). Mitochondria and mitochondrial cell‐cycle proteins were overexpressed in patients withCYP2D6CNV.ConclusionsTumorCYP2D6CNV identified patients with a significantly worse DFS at 5 years among localized ASCC patients treated with 5‐fluorouracil, mitomycin C, and radiotherapy. Proteomics pointed out mitochondria and mitochondrial cell‐cycle genes as possible therapeutic targets for these high‐risk patients.Plain Language SummaryAnal squamous cell carcinoma is an infrequent tumor whose treatment has not been changed since the 1970s.However, disease‐free survival in late staged tumors is between 40% and 70%.The presence of an alteration in the number of copies ofCYP2D6gene is a biomarker of worse disease‐free survival.The analysis of the proteins in these high‐risk patients pointed out mitochondria and mitochondrial cell‐cycle genes as possible therapeutic targets.Therefore, the determination of the number of copies ofCYP2D6allows the identification of anal squamous carcinoma patients with a high‐risk of relapse that could be redirected to a clinical trial.Additionally, this study may be useful to suggest new treatment strategies to increase current therapy efficacy.
Experimental validation of a new model for mandibular motions
Authors: Ke Si‐peng , Cheng Kang‐jie , Wang Russell , Jiang Xian‐feng , Liu Yun‐feng 
Published: April 2023

AbstractLong‐term excessive forces loading from muscles of mastication during mandibular motions may result in disorders of temporomandibular joint (TMJ), myofascial pain, and restriction of jaw opening and closing. Current analysis of mandibular movements is generally conducted with a single opening, protrusive and lateral movements rather than composite motions that the three can be combined arbitrarily. The objective of this study was to construct theoretical equations reflecting the correlation between composite motions and muscle forces, and consequently to analyze the mandibular composite motions and the tensions of muscles of mastication in multiple dimensions. The muscle performances such as strength, power, and endurance of mandibular motions were analyzed and the effective motion range of each muscle was derived. The mandibular composite motion model was simplified by calculating muscle forces. An orthogonal rotation matrix based on muscle forces was established. A 3D printed mandible was used for in vitro simulation of mandibular motions on a robot and measurements of force were conducted. The theoretical model and forces were verified through a trajectory tracing experiment of mandibular motions driven by a 6‐axis robot with force/torque sensors. Through the analysis of the mandibular composite motion model, the motion form was obtained and transferred to guide the motions of the robot. The error between the experimental data obtained by the 6‐axis force/torque sensors and the theoretical data was within 0.6 N. Our system provides excellent visualization for analyzing the changes of muscle forces and locations during various mandibular movements. It is useful for clinicians to diagnose and formulate treatment for patients who suffer from (temporomandibular joint disorders) TMDs and restrict jaw movements. The system can potentially offer the comparison before and after treatment of TMDs or jaw surgery.
Modified Phenol/Chloroform‐Free DNA Isolation from Yeast and Other Fungi by Non‐Enzymatic Salting Out Method
Authors: Bandehpour Mojgan , Dehghani Niloofar , Jaliani Hossein Zarei , Asadi‐saghandi Abolghasem 
Published: April 2023

AbstractThe most commonly used fungal DNA extraction techniques require enzymatic digestion or hazardous chemicals. Here, we describe a quick non‐enzymatic salt‐out method that we developed for isolating high‐quality DNA from various fungal species. DNA was extracted from four species of typical fungi, including Saccharomyces cerevisiae, Hansenula polymorpha, Candida albicans, and Aspergillus flavus. Results that we obtained from agarose gel electrophoresis and spectrophotometry verified the integrity, high quality, and purity of the extracted DNAs. Also, PCR amplification and restriction enzyme digestion confirmed the efficiency of the extracted DNAs in molecular biology applications. © 2023 Wiley Periodicals LLC.Basic Protocol 1: Yeast and fungal cultivation for DNA extractionBasic Protocol 2: Modified salting out DNA extraction protocolSupport Protocol 1: PCR amplification of extracted genomesSupport Protocol 2: Digestion with restriction enzyme
Enabling positive intergroup relations through the utility of moral exemplars among young adults in post‐conflict settings
Authors: Opacin Nerkez 
Published: April 2023

AbstractThe article explores the role of moral exemplars as an approach to dealing with and learning from the past as part of peacebuilding education initiatives (PEIs) operating in Southeast Europe. To this day, a deeply rooted divide along ethnic lines is present throughout the region, with each ethnic group using separate narratives and educational programs, providing the youth with little space to meet and learn about the past and outgroup members. Civil society increasingly introduces PEIs that target adolescents through experiential learning approaches. Based on 12‐month‐long multi‐sited ethnographic research into four peacebuilding approaches, this article addresses three outcomes connected with the use of the moral exemplars approach in peacebuilding intervention programs. These include (1) a greater desire to learn about the past, outgroup members, and each other in post‐conflict and divided settings, (2) a greater chance to form cross‐group friendships as well as (3) a drive to take concrete steps toward peacebuilding in the participants' local communities.
Determinants of informal care time, distress, depression, and quality of life in care partners along the trajectory of Alzheimer's disease
Authors: Mank Arenda , van Maurik Ingrid S. , Rijnhart Judith J. M. , Rhodius‐Meester Hanneke F. M. , Visser Leonie N. C. , Lemstra Afina W. , Sikkes Sietske A. M. , Teunissen Charlotte E. , van Giessen Elsmarieke M. , Berkhof Johannes , van der Flier Wiesje M. 
Published: April 2023

AbstractIntroductionWe evaluated determinants associated with care partner outcomes along the Alzheimer's disease (AD) stages.MethodsWe included n = 270 care partners of amyloid‐positive patients in the pre‐dementia and dementia stages of AD. Using linear regression analysis, we examined determinants of four care partner outcomes: informal care time, caregiver distress, depression, and quality of life (QoL).ResultsMore behavioral symptoms and functional impairment in patients were associated with more informal care time and depressive symptoms in care partners. More behavioral symptoms were related with more caregiver distress. Spouse care partners spent more time on informal care and QoL was lower in female care partners. Behavioral problems and subtle functional impairment of the patient predisposed for worse care partner outcomes already in the pre‐dementia stages.DiscussionBoth patient and care partner determinants contribute to the care partner outcomes, already in early disease stages. This study provides red flags for high care partner burden.
Multicomponent Reactions Based on SO2 Surrogates: Recent Advances
Authors: Chen Gang , Lian Zhong 
Published: April 2023

AbstractCompounds containing sulfonyl‐derived functional groups have received intensive attention owing to their widespread applications in life science, pharmaceuticals and materials science. To access this type of compounds, the multi‐component sulfonylation reactions relying on sulfur dioxide (SO2) insertion strategy have emerged as novel and attractive approaches in the past decade. The utilization of SO2 surrogates for SO2 insertion in the multicomponent reactions (MCRs) have improved reaction flexibility and step economy. Moreover, some advances have been achieved in the challenging but practical asymmetric MCRs for the construction of high value‐added chiral sulfones. This review aims to summarize the progress made in the MCRs involving SO2 surrogates from 2019 to 2022, and point out the potentials and challenges in this field.
Proton therapy and/or helical tomotherapy for locally advanced sinonasal skull base adenoid cystic carcinoma: Focus on experience of the Institut Curie and review of literature
Authors: Mavrikios Antoine , Goudjil Farid , Beddok Arnaud , Zefkili Sofia , Bolle Stéphanie , Feuvret Loic , Le Tourneau Christophe , Choussy Olivier , Sauvaget Elisabeth , Herman Philippe , Dendale Rémi , Calugaru Valentin 
Published: April 2023

AbstractBackgroundSinonasal adenoid cystic carcinomas (SNACC) have high propensity for skull base (SB) infiltration. Unresectability or incomplete surgical resection in such cases make radiotherapy treatment paramount. Curative dose escalation is challenging because of adjacent organs at risk, especially in locally advanced cases.MethodsEighteen patients that had locally advanced SB SNACC with unresectable or incomplete surgical resection treated by proton therapy and/or helical tomotherapy at Institut Curie between 3/2010 and 8/2020 were retrospectively included.ResultsAfter median follow‐up of 52 months, 5‐year OS, LRRFS, DMFS, DFS rates were, respectively, 47% (95%CI: 26–83), 50% (95%CI: 36–88), 39% (95%CI: 26–81), 33% (95%CI: 22–73). One patient had grade 4 late optic nerve disorder. Eight patients had grade 3 late toxicity including mainly hearing impairments.ConclusionProton therapy and helical tomotherapy are effective and safe methods for curative dose escalation of locally advanced SB SNACC, which are a poor prognosis subgroup. Available literature suggests carbon‐ion therapy could be an efficient alternative.