bluuebunny/crossref_metadata_2025_split huggingface dataset:
Betaine lipids of Symbiodiniaceae hosted by Indo‐Pacific corals
Authors: Sikorskaya Tatyana V. , Ermolenko Ekaterina V. , Long Pham Quoc 
Published: July 2023

SUMMARYThe total pool of coral lipids consists of lipids produced by both the coral host and its symbiotic dinoflagellates of the family Symbiodiniaceae. Betaine lipids (BL) are characteristic of plasma membranes of microalgae. Composition of such BL as 1,2‐diacylglyceryl‐3‐O‐carboxy‐(hydroxymethyl)‐choline (DGCC) that occur in coral symbionts may depend on either Symbiodiniaceae species or coral species. Membrane‐forming lipids DGCC have a zwitterion structure similar to that of phosphatidylcholine (PC). They can substitute for each other to a substantial extent, certainly in relation to membrane functions. In the present study, the profiles of DGCC and diacyl PC molecular species of symbiotic dinoflagellates from Acropora sp., Millepora platyphylla and Sinularia flexibilis were determined by high‐performance liquid chromatography with high‐resolution mass‐spectrometry. Colonies of Acropora sp. were characterized by higher contents of DGCC with eicosapentaenoic acid (20:5n‐3) and C28 polyunsaturated fatty acids; S. flexibilis, by a higher content of DGCC with palmitic acid (16:0); and M. platyphylla, by a higher content of DGCC with docosahexaenoic acid (22:6n‐3). Although the DGCC profile of the corals under study has distinctive features, it shows both similarities with and differences from the DGCC profiles of previously studied corals. Probably, each coral symbiont species has its own specific DGCC molecular species profile that is additionally modified in a certain way depending on environmental conditions created by the coral host. Molecular species DGCC and PC profiles were different. The most abundant PC molecular species were 16:0/22:5 and 38:4 in Acropora sp.; 39:5 and 38:4 in S. flexibilis; and 38:6, 16:0/22:5 and 18:0/22:6 in M. platyphylla. Thus, there is no clear evidence for any compensation or interchangeability between PC and DGCC.
The Cognitive Costs of Design Tasks: Examining Cognitive Load Through Verbal and Physical Indicators
Authors: Calpin Nicole , Menold Jessica 
Published: July 2023

Abstract
Prior work has demonstrated that design tasks can be cognitively demanding, due to the inherent ambiguity and complexity of design problems. Few studies, however, have examined the evolution of cognitive load during the engineering design process and the linkages between subdimensions of cognitive load and design task outcomes. To address this gap, the current work investigates the evolution of cognitive load across two distinct design tasks: ideation and prototyping, and the relationship between cognitive load and design task outcomes. Results suggest that there is a significant difference in cognitive load experienced by the designer during ideation and prototyping. Additionally, findings suggest that cognitive load during ideation is positively correlated with the uniqueness, usefulness, and elegance of ideas.
Comparing severe COVID-19 outcomes of first and second/third waves: a prospective single-centre cohort study of health-related quality of life and pulmonary outcomes 6 months after infection
Authors: Darlington Pernilla , Roël Mari , Cronhjort Maria , Hanna Gabriel , Hedman Anders , Joelsson-Alm Eva , Schandl Anna 
Published: July 2023

ObjectiveWe aimed to compare long-term outcomes in intensive care unit (ICU) survivors between the first and second/third waves of the COVID-19 pandemic. More specifically, to assess health-related quality of life (HRQL) and respiratory health 6 months post-ICU and to study potential associations between patient characteristic and treatment variables regarding 6-month outcomes.DesignProspective cohort study.SettingSingle-centre study of adult COVID-19 patients with respiratory distress admitted to two Swedish ICUs during the first wave (1 March 2020–1 September 2020) and second/third waves (2 September 2020– 1 August 2021) with follow-up approximately 6 months after ICU discharge.ParticipantsCritically ill COVID-19 patients who survived for at least 90 days.Main outcome measuresHRQL, extent of residual changes on chest CT scan and pulmonary function were compared between the waves. General linear regression and multivariable logistic regression were used to present mean score differences (MSD) and ORs with 95% CIs.ResultsOf the 456 (67%) critically ill COVID-19 patients who survived at least 90 days, 278 (61%) were included in the study. Six months after ICU discharge, HRQL was similar between survivors in the pandemic waves, except that the second/third wave survivors had better role physical (MSD 20.2, 95% CI 7.3 to 33.1, p<0.01) and general health (MSD 7.2, 95% CI 0.7 to 13.6, p=0.03) and less bodily pain (MSD 12.2, 95% CI 3.6 to 20.8, p<0.01), while first wave survivors had better diffusing capacity of the lungs for carbon monoxide (OR 1.9, 95% CI 1.1 to 3.5, p=0.03).ConclusionsThis study indicates that even though intensive care treatment strategies have changed with time, there are few differences in long-term HRQL and respiratory health seems to remain at 6 months for patients surviving critical COVID-19 in the first and second/third waves of the pandemic.
Is personalised prehabilitation feasible to implement for patients undergoing oncological treatment for lung cancer at a London teaching hospital? Protocol of a feasibility trial
Authors: Wade-Mcbane Kelly , King Alex , Urch Catherine , Johansson Lina , Wells Mary 
Published: July 2023

IntroductionThere is significant potential to improve outcomes for patients with lung cancer in terms of quality of life and survival. There is some evidence that prehabilitation can help, but, to date, this has only been tested in surgical populations, despite 70%–80% of patients with lung cancer in the UK receiving non-surgical treatment. The physiological and psychological benefits of prehabilitation seen in surgical patients could be extrapolated to those receiving non-surgical treatment, particularly in such a poor prognosis group. With patients and healthcare professionals, we have co-designed a personalised and evidence-based prehabilitation programme. This draws on a conceptual framework that aligns with patient values and needs as well as functional goals. We aim to investigate whether this programme is feasible to implement and evaluate in clinical practice.Methods and analysisAn open-label, single-group feasibility study incorporating quantitative assessments, a qualitative free text questionnaire and reflective field notes. Thirty participants will be recruited over an eight-month period from a single London teaching hospital. All recruited participants will receive a personalised prehabilitation programme during their oncological treatment. This includes a one-hour face-to-face appointment prior to, at week three and at week six of their treatment regimen as well as a weekly telephone call. Interventions including nutrition, physical activity and psychological well-being are stratified according to a patient’s priorities, level of readiness and expressed needs. The primary outcome will be feasibility of the personalised prehabilitation programme in clinical practice by investigating areas of uncertainty regarding patient recruitment, attrition, treatment fidelity, intervention adherence and acceptability of study outcome measures. Secondary outcomes will include quality of life, functional capacity and grip strength.Ethics and disseminationEthical approval has been obtained from the Health Research Authority (reference number 22/PR/0390). Results of this study will be disseminated through publication in peer-reviewed articles, presentations at scientific conferences and in collaboration with patient and public involvement representatives.Trial registration numberNCT05318807.
Scapegoats and Underdogs: Narrative Control and Defence Positioning within and Beyond the International Criminal Court
Authors: Godzimirska Zuzanna , Orina Nabil M. 
Published: July 2023

Abstract
Building on a growing body of scholarship that accentuates the communicative foundations and dimensions of international criminal justice, the article explores how defendants and their defence teams navigate the discursive battleground in the course of trials at the International Criminal Court (icc). Given the central role of narratives in the construction and (de)legitimation of identities, and their profound implications for perceptions about trial participants, the article seeks to understand what implications defences’ relative disadvantage vis-á-vis the prosecutions’ in terms of institutional support, access to resources and media visibility, have for their strategies of narrative control and positioning. To this end, the article charts the discursive battle sites at global, regional and local levels, maps specific strategies of narrative control in these sites, and zooms in on two prominent themes in the identity construction of defendants within and beyond the icc courtroom.
Hopes Ablaze: Reimagining the Revolutionary Alternative in the Ambazonian War of Independence
Authors: Ngoe Blessed E. 
Published: July 2023

Abstract
This essay examines the prefigurative politics that birthed and has sustained the Ambazonian revolutionary movement and its war of independence in Cameroon. It uses Critical Discourse Analysis (CDA) to question the extent to which foundational value based Ambazonian discourses have lived up to the objectives of the movement’s founding. An analysis of speeches, official documents, and video content from Ambazonian leaders reveals that (1) the Ambazonian objective to secede from the state of Cameroon was initially discursively premised on prefigurative ideals, (2) the surge of radical discourses and the imprisonment of pioneer leaders of the movement prompted a deviation from the movement’s foundational goals, and (3) there is a need to reimagine the revolutionary alternative in the promised liberation of English-speaking Cameroonians.
Impact of modifiable risk factors on prediction of 10-year cardiovascular disease utilizing framingham risk score in Southwest Iran
Authors: Saki Nader , Babaahmadi-Rezaei Hossein , Rahimi Zahra , Raeisizadeh Maedeh , Jorfi Fateme , Seif Faeze , Cheraghian Bahman , Ghaderi-Zefrehi Hossien , Rezaei Maryam 
Published: July 2023

Abstract
Background
This cohort study was conducted to examine the association between modifiable risk factors, including hypertension, smoking, physical activity, diabetes, cholesterol, and high-density lipoprotein with Framingham risk score in the prediction of 10-year-risk of cardiovascular diseases (CVD) between men and women in an Arab community of Southwest Iran, Hoveyzeh.

Materials and methods
A total of 8,526 people aged 35–70 participated in this cohort study. Framingham was used to estimate the 10-year risk of CVD. Also, the linear regression models were used to assess the relationship between modifiable risk factors and the 10-year risk of CVD. Finally, the area under the receiver operating characteristic curve (AUC) was used to measure the ability of modifiable risk factors to predict the 10-year risk of CVD.

Results
Our results of linear regression models showed that hypertension, smoking, PA, diabetes, cholesterol, and HDL were independently associated with the CVD risk in men and women. Also, AUC analysis showed that hypertension and diabetes have the largest AUC in men 0.841; 0.778 and in women 0.776; 0.715, respectively. However, physical activity had the highest AUC just in women 0.717.

Conclusion
Hypertension and diabetes in both gender and physical activity in women are the most important determinant for the prediction of CVD risk in Hoveyzeh. Our cohort study may be useful for adopting strategies to reduce CVD progression through lifestyle changes.
Relationship between pulse pressure and body mass index in active-duty Royal Thai Army personnel in Thailand
Authors: Sakboonyarat Boonsub , Poovieng Jaturon , Sangkool Tanatip , Lertsakulbunlue Sethapong , Jongcherdchootrakul Kanlaya , Srisawat Phutsapong , Mungthin Mathirut , Rangsin Ram 
Published: July 2023

Abstract
Background
Elevated pulse pressure (PP) is a robust independent predictor of cardiovascular diseases. The relationship between PP and body mass index (BMI) was presented in a few studies. However, the findings were inconsistent. Therefore, the aim of the present study is to identify the association between elevated PP and BMI using a large sample of active-duty Royal Thai Army (RTA) personnel.

Methods
A cross-sectional study was conducted through the use of the dataset obtained from the annual health examination database of RTA personnel in Thailand in 2022. BMI 25.0–29.9 kg/m2 was classified as obesity I, whereas BMI ≥ 30.0 kg/m2 was classified as obesity II. Elevated PP was defined as PP ≥ 50 mmHg. Multivariable linear regression and log-binomial regression models were utilized for determining the association between elevated PP and BMI.

Results
A total of 62,113 active-duty RTA personnel were included in the study. The average BMI was 25.4 ± 3.8 kg/m2, while the average PP was 50.1 ± 11.2 mmHg. Compared to individuals with normal weight, the $$\beta$$
β
coefficients of PP and BMI were 1.38 (95% CI: 1.15–1.60) and 2.57 (95% CI: 2.25–2.88) in individuals with obesity I and obesity II, respectively. Effect modification by high blood pressure (BP) on the association between elevated PP and BMI was observed. Among participants with normal BP, in comparison with BMI of 18.5–22.9 kg/m2, the adjusted prevalence ratio (PR) for elevated PP was 1.23 (95% CI: 1.19–1.28) and 1.41 (95% CI: 1.35–1.48) in those with obesity I and obesity II, respectively. Meanwhile, among individuals with high BP, the adjusted PR for elevated PP was 1.05 (95% CI: 1.01–1.08) and 1.09 (95% CI: 1.06–1.13) in those with obesity I and obesity II, respectively.

Conclusion
PP was positively associated with BMI in active-duty RTA personnel. High BP was the modifier of the association between PP and BMI. A weaker association between elevated PP and BMI was observed among RTA personnel with high BP.
Hyperinflammatory syndrome in a paediatric patient with a recent diagnosis of HIV/AIDS infection: hemophagocytic lymphohistiocytosis or immune reconstitution syndrome?
Authors: Leone Fabrizio , Cotugno Nicola , Casamento Tumeo Chiara , Zangari Paola , Palomba Patrizia , Adorisio Rachele , De Benedetti Fabrizio , Bracaglia Claudia , Papoff Paola , Ajassa Camilla , Palma Paolo , Bernardi Stefania 
Published: July 2023

Abstract
Introduction
Haemophagocytic lymphohistiocytosis is a rare and life-threatening condition caused by uncontrolled immune activation leading to excessive inflammation and tissue destruction. It could either be due to a primary genetic defect or be triggered by secondary causes such as infections, autoimmune diseases, rheumatological diseases or post-transplant immunosuppression. We here report the case of a 4-year-old child with a recent AIDS diagnosis who developed a severe systemic inflammation.

Case report
We here report the case of a 4-year-old child with a recent AIDS diagnosis who was admitted to the ER with acute respiratory failure due to Pneumocystis jiroveci infection and Aspergillosis; the following microbiological assessment also showed a CMV, HSV, EBV and HHV-7 coinfection. On the 51st day after she’d started antiretroviral therapy, 39th after she’d followed a course of Bactrim and Caspofungin for PJI and Ambisome for pulmonary Aspergillosis, she started presenting fever, unresponsive to broad-spectrum antibiotic therapy. She also presented worsening of her clinical conditions, with evidence at the laboratory assessments of progressive raise in inflammatory indexes, coagulopathy, trilinear cytopenia and hyperferritinemia. To perform the differential diagnosis between IRIS and HLH, HLA-DR on T cells was studied, turning out negative for IRIS. Therefore, in the suspicion of HLH, a bone marrow aspirate and biopsy were performed with evidence of trilinear cytopenia, prevalence of T-cells and macrophages with signs of phagocytosis. She was started on high-dose steroids and Anakinra for a total of 29 days, resulting in prompt apyrexia and progressive improvement of her clinical conditions and laboratory results.

Conclusion
To the best of our knowledge there is poor literature available about the differential diagnosis of HLH and IRIS, therefore medical management in the concurrence of these two conditions needs to be further investigated, especially in a setting where immunological testing is not quickly available. The clinical differences between these pathologies are blurred and the bone marrow biopsy within marker for IRIS helped us to distinguish these two entities.
The value of allied health professional research engagement on healthcare performance: a systematic review
Authors: Chalmers S. , Hill J. , Connell L. , Ackerley S. , Kulkarni A. , Roddam H. 
Published: July 2023

AbstractBackgroundExisting evidence suggests that clinician and organisation engagement in research can improve healthcare performance. With the increase in allied health professional (AHP) research activity, it is imperative for healthcare organisations, clinicians, managers, and leaders to understand research engagement specifically within allied health fields. This systematic review aims to examine the value of research engagement by allied health professionals and organisations on healthcare performance.MethodsThis systematic review had a two-stage search strategy. Firstly, the papers from a previous systematic review examining the effect of research engagement in healthcare were screened to identify papers published pre-2012. Secondly, a multi-database search was used to conduct a re-focused update of the previous review, focusing specifically on allied health to identify publications from 2012–2021. Studies which examined the value of allied health research engagement on healthcare performance were included. All stages of the review were conducted by two reviewers independently. Each study was assessed using the appropriate Joanna Briggs Institute critical appraisal tool. A narrative synthesis was completed to analyse the similarities and differences between and within the different study types.ResultsTwenty-two studies were included, comprising of mixed research designs, of which six were ranked as high importance. The findings indicated that AHP research engagement appears related to positive findings in improvements to processes of care. The review also identified the most common mechanisms which may link research engagement with these improvements.DiscussionThis landmark systematic review and narrative synthesis suggests value in AHP research engagement in terms of both processes of care and more tentatively, of healthcare outcomes. While caution is required because of the lack of robust research studies, overall the findings support the agenda for growing AHP research. Recommendations are made to improve transparent reporting of AHP research engagement and to contribute essential evidence of the value of AHP research engagement.Trial registrationThis systematic review protocol was registered with the international prospective register of systematic reviews, PROSPERO (registration numberCRD42021253461).
Anatomical and imaging measurements of the angle between the axis of the lumbar pedicle and lateral isthmus margin and its clinical significance
Authors: Wang Shuiquan , Aikeremu Dilimulati , Kahaer Alafate , Maimaiti Abulikemu , Xiao Yang , Tuoheti Abudusalamu , Zhang Rui , Maimaiti Xieraili , Guo Hailong , Rexiti Paerhati 
Published: July 2023

Abstract
Background
This study aims to explore the measurement of the angle between the axis of the pedicle and the lateral margin of the isthmus on the lumbar spine, and investigate its clinical significance.

Methods
The angle was measured on 120 normal adults’ X-ray and 25 dry anatomical specimens. 60 screws were placed by junior residents on 6 wet specimens through the freehand technique. 30 screws were placed on one side with their original experience. After learning the techniques mentioned in the study, 30 screws were placed on the other side. The specimens were examined by X-ray and CT, and the angles of the screw paths and the integrity of the pedicle were evaluated.

Results
The angles of 120 subjects and 25 anatomical specimens show a gradually increasing trend. The differences among each segment were statistically significant (P < 0.05), but the difference in the same segment between the X-ray and the anatomical specimens was not statistically significant (P > 0.05). Furthermore, the differences in L1, L2, and L3 between the two genders were not statistically significant (P > 0.05). However, the angles were larger in female group than in male group in L4 and L5, and the differences were statistically significant (P < 0.05). The difference in the deviation rate of screw placement before and after the learning was statistically significant only in the L5 segment (P < 0.05). The difference in overall excellence rate was statistically significant (P < 0.05).

Conclusions
The measurement of the angle between the axis of the pedicle and the lateral margin of the isthmus on the lumbar can improve the accuracy of the lumbar sagittal screw angle.
Tertiary care for infertile couples: aetiological diagnoses and conventional treatment outcomes in Kisangani, Democratic Republic of the Congo
Authors: Bosenge-Nguma Jean-Didier , O’yandjo Antoine Modia , Sihalikyolo Juakali , Otuli Noël Labama , Ntokamunda Kadima , Agasa Batina , Bosunga Katenga 
Published: July 2023

Abstract
Background
In sub-Saharan Africa, tubal factors are described as the main aetiological factors of infertility. Under these conditions, medically assisted procreation is particularly indicated. However, Assisted Reproductive Technology centres are less available. Thus, infertile couples are quickly oriented towards available alternative conventional treatments. The present study aimed to determine the aetiological factors of infertility, the outcomes of the therapeutic options offered, and the factors associated with the success of conventional treatment among infertile couples seeking tertiary care in Kisangani.

Methods
A cross-sectional study was conducted at two tertiary health facilities in Kisangani. Infertile couples who provided consent underwent specific examinations necessary for the exploration of infertility and were treated and followed up for a minimum of 6 months. The therapeutic options that were offered were expectant attitude, medical treatment, surgical treatment or transfer to an in vitro fertilization unit. The pregnancy diagnosis was performed by ultrasound.

Results
A total of 272 infertile couples underwent specific examinations, were treated and were followed up for a minimum of 6 months. Many determinant causes were mostly linked to wives rather than husbands. Overall, only 34 women among 211 who were treated became pregnant during the follow-up period; 61 couples were advised to resort to IVF or adoption, but the couples for whom expectant the attitude was indicated immediately rejected it. The patients who therapeutically succeeded at the end of the treatment were those who were younger than 35 years (OR = 2.27; 95% CI = 1.06–4.87; P = 0.017), had a duration of infertility of less than five years (OR = 6.08; 95% CI = 1.79–20.69; P = 0.001) and had secondary infertility (OR = 6.08; 95% CI = 1.79–20.69; P = 0.001).

Conclusion
Kisangani faces a major issue in the treatment of infertility. Treatment of patients using conventional methods is limited by the predominance of tubal factors as aetiological determinants of infertility. The low pregnancy rate found in this study provided additional evidence of this. This paper represents a serious plea to national policy-makers to encourage them to pay attention to issues surrounding infertility.