bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malaria in adults after the start of Covid-19 pandemic: an analysis of admission trends, demographics, and outcomes in a tertiary hospital in the Gambia
Authors: Bittaye Sheikh Omar , Jagne Abubacarr , Jaiteh Lamin E. S. , Amambua-Ngwa Alfred , Sesay Abdul Karim , Ekeh Bertha , Nadjm Behzad , Ramirez Williams Estrada , Ramos Asmell , Okeahialam Basil , Effa Emmanuel , Nyan Ousman , Njie Ramou 
Published: September 2023

Abstract
Background
Malaria remains a major public health concern in The Gambia. The study assessed the trend of malaria admissions and outcome of adult patients admitted after the start of the COVID-19 pandemic in a tertiary hospital in The Gambia.

Methods
This was a retrospective hospital-based study and data was collected from the 18th October 2020 to 28th February 2023. Demographic data, clinical features, investigations, treatment, and outcomes were recorded.

Results
A total of 499 malaria cases were admitted to the hospital over the 29 months of the study period. Data from 320 (67.2% of the total cases) adult patients admitted into the internal medicine department were analysed. The median age was 22 years, range (15–90) and 189 (59.1%) cases were youth with a youth (15–24 years) to older adult (> 24 years) ratio of 1.4:1. The majority of the patients were male 199 (62.2) with a male to female ratio of 1.6:1. The total number of malaria cases admitted into the internal medicine department increased from 103 cases in 2021 to 182 cases in 2022and admission peaked in November in both years. The total number of admitted malaria cases during the peak of the malaria season also increased from 92 patients between September 2021 and December 2021 to 132 patients from September 2022 to December 2022.There was also an increase in both severe and uncomplicated malaria during the same period. The total mortality was 31 (9.7%) and the rate was similar in 2021 9 (8.7%) and 2022 15 (8.4%). Patients with impaired consciousness were more likely to die when compared to those without impaired consciousness [19 (23.6%) vs 12 (5%), p  ≤ 0.001]. Patients with acute kidney injury were also more likely to die when compared with those without acute kidney injury [10 (20.4%) vs 15 (7.7%), p = 0.009].

Conclusion
The findings show an emerging and consistent trend of malaria admissions and the outcome in the youth and older adult population after the start of the COVID-19 pandemic in The Gambia. This, therefore, suggests the need for the implementation of targeted malaria prevention interventions in this population to further prevent the spread of the disease to the more vulnerable population.
Chemogenetic activation of locus coeruleus neurons ameliorates the severity of multiple sclerosis
Authors: Torrillas-de la Cal Alejandro , Torres-Sanchez Sonia , Bravo Lidia , Llorca-Torralba Meritxell , Garcia-Partida Jose Antonio , Arroba Ana I. , Berrocoso Esther 
Published: September 2023

Abstract
Background
Most current disease-modifying therapies approved for multiple sclerosis (MS) are immunomodulatory drugs that counteract the aberrant activity of the immune system. Hence, new pharmacological interventions that drive anti-inflammatory activity and neuroprotection would represent interesting alternative therapeutic approaches or complementary strategies to treat progressive forms of MS. There is evidence of reduced noradrenaline levels and alterations to locus coeruleus (LC) noradrenergic neurons in MS patients, as well as in animal models of this disease, potentially factors contributing to the pathophysiology. Drugs that enhance noradrenaline appear to have some beneficial effects in MS, suggesting their potential to dampen the underlying pathology and disease progression.

Methods
Therefore, we explored the consequences of chronic LC noradrenergic neurons activation by chemogenetics in experimental autoimmune encephalomyelitis (EAE) mice, the most widely used experimental model of MS. LC activation from the onset or the peak of motor symptoms was explored as two different therapeutic approaches, assessing the motor and non-motor behavioral changes as EAE progresses, and studying demyelination, inflammation and glial activation in the spinal cord and cerebral cortex during the chronic phase of EAE.

Results
LC activation from the onset of motor symptoms markedly alleviated the motor deficits in EAE mice, as well as their anxiety-like behavior and sickness, in conjunction with reduced demyelination and perivascular infiltration in the spinal cord and glial activation in the spinal cord and prefrontal cortex (PFC). When animals exhibited severe paralysis, LC activation produced a modest alleviation of EAE motor symptoms and it enhanced animal well-being, in association with an improvement of the EAE pathology at the spinal cord and PFC level. Interestingly, the reduced dopamine beta-hydroxylase expression associated with EAE in the spinal cord and PFC was reversed through chemogenetic LC activation.

Conclusion
Therefore, clear anti-inflammatory and neuroprotective effects were produced by the selective activation of LC noradrenergic neurons in EAE mice, having greater benefits when LC activation commenced earlier. Overall, these data suggest noradrenergic LC neurons may be targets to potentially alleviate some of the motor and non-motor symptoms in MS.
Open-source workflow design and management software to interrogate duckweed growth conditions and stress responses
Authors: Scott Madeline , de Lange Orlando , Quaranto Xavaar , Cardiff Ryan , Klavins Eric 
Published: September 2023

AbstractDuckweeds, a family of floating aquatic plants, are ideal model plants for laboratory experiments because they are small, easy to cultivate, and reproduce quickly. Duckweed cultivation, for the purposes of scientific research, requires that lineages are maintained as continuous populations of asexually propagating fronds, so research teams need to develop optimized cultivation conditions and coordinate maintenance tasks for duckweed stocks. Additionally, computational image analysis is proving to be a powerful duckweed research tool, but researchers lack software tools to assist with data collection and storage in a way that can feed into scripted data analysis. We set out to support these processes using a laboratory management software called Aquarium, an open-source application developed to manage laboratory inventory and plan experiments. We developed a suite of duckweed cultivation and experimentation operation types in Aquarium, which we then integrated with novel data analysis scripts. We then demonstrated the efficacy of our system with a series of image-based growth assays, and explored how our framework could be used to develop optimized cultivation protocols. We discuss the unexpected advantages and the limitations of this approach, suggesting areas for future software tool development. In its current state, our approach helps to bridge the gap between laboratory implementation and data analytical software for duckweed biologists and builds a foundation for future development of end-to-end computational tools in plant science.
Subjective versus objective sleep in men with Klinefelter syndrome
Authors: Fjermestad K. W. , Finnbakk R. R. , Solbakk A.-K. , Gravholt C. H. , Huster R. J. 
Published: September 2023

Abstract
Objectives
To investigate sleep among men with Klinefelter syndrome (KS).

Method
We compared the sleep domains latency, disturbance, and efficiency in 30 men with KS (M age = 36.7 years, SD = 10.6) to 21 age-matched non-KS controls (M age = 36.8 years, SD = 14.4). Actigraphs were used to objectively measure sleep across 7 days and nights. Participants also completed a sleep diary over the same period, and the Pittsburgh Sleep Quality Index (PSQI).

Results
The mean correlation between the objective and subjective sleep measures was lower for the KS sample (M r = .15) than for controls (M r = .34). Sleep disturbance was significantly larger in the KS sample, as measured by actigraphy (p = .022, d = 0.71) and the PSQI (p = .037, d = 0.61). In regression models predicting sleep domains from KS status, age, educational level, vocational status, IQ, and mental health, KS status was not a significant predictor. Higher age was associated with more actigraphy-measured sleep disturbance. Higher educational level and being employed were associated with better sleep efficiency.

Conclusions
Sleep disturbance may be a particular problem for men with KS and should be measured with complimentary methods.
Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations
Authors: Zhang Bin , He Rui , Xu Zigang , Sun Yujuan , Wei Li , Li Li , Liu Yuanxiang , Guo Wu , Song Li , Wang Huijun , Lin Zhimiao , Ma Lin 
Published: September 2023

Abstract
Background
Somatic mutations of cancer driver genes are found to be responsible for vascular malformations with clinical manifestations ranging from cutaneous birthmarks to life-threatening systemic anomalies. Till now, only a limited number of cases and mutations were reported in Chinese population. The purpose of this study was to describe the somatic mutation spectrum of a cohort of Chinese pediatrics with vascular malformations.

Methods
Pediatrics diagnosed with various vascular malformations were collected between May 2019 and October 2020 from Beijing Children’s Hospital. Genomic DNA of skin lesion of each patient was extracted and sequenced by whole-exome sequencing to identify pathogenic somatic mutations. Mutations with variant allele frequency less than 5% were validated by ultra-deep sequencing.

Results
A total of 67 pediatrics (33 males, 34 females, age range: 0.1–14.8 years) were analyzed. Exome sequencing identified somatic mutations of corresponding genes in 53 patients, yielding a molecular diagnosis rate of 79.1%. Among 29 PIK3CA mutations, 17 were well-known hotspot p.E542K, p.E545K and p.H1047R/L. Non-hotspot mutations were prevalent in patients with PIK3CA-related overgrowth spectrum, accounting for 50.0% (11/22) of detected mutations. The hotspot GNAQ p.R183Q and TEK p.L914F mutations were responsible for the majority of port-wine stain/Sturge–Weber syndrome and venous malformation, respectively. In addition, we identified a novel AKT1 p.Q79K mutation in Proteus syndrome and MAP3K3 p.E387D mutation in verrucous venous malformation.

Conclusions
The somatic mutation spectrum of vascular malformations in Chinese population is similar to that reported in other populations, but non-hotspot PIK3CA mutations may also be prevalent. Molecular diagnosis may help the clinical diagnosis, treatment and management of these pediatric patients with vascular malformations.
Biomechanical effect of neurologic dance training (NDT) for breast cancer survivors with chemotherapy-induced neuropathy: study protocol for a randomized controlled trial and preliminary baseline data
Authors: Lantis Kristen , Schnell Patrick , Bland Courtney R. , Wilder Jacqueline , Hock Karen , Vargo Craig , Glover Nelson A. , Hackney Madeleine E. , Lustberg Maryam B. , Worthen-Chaudhari Lise 
Published: September 2023

Abstract
Background
Breast cancer (BC) is among the most common forms of cancer experienced by women. Up to 80% of BC survivors treated with chemotherapy experience chemotherapy-induced neuropathy (CIN), which degrades motor control, sensory function, and quality of life. CIN symptoms include numbness, tingling, and/or burning sensations in the extremities; deficits in neuromotor control; and increased fall risk. Physical activity (PA) and music-based medicine (MBM) are promising avenues to address sensorimotor symptoms. Therefore, we propose that we can combine the effects of music- and PA-based medicine through neurologic dance training (NDT) through partnered Adapted Tango (NDT-Tango). We will assess the intervention effect of NDT-Tango v. home exercise (HEX) intervention on biomechanically-measured variables. We hypothesize that 8 weeks of NDT-Tango practice will improve the dynamics of posture and gait more than 8 weeks of HEX.

Methods
In a single-center, prospective, two-arm randomized controlled clinical trial, participants are randomly assigned (1:1 ratio) to the NDT-Tango experimental or the HEX active control intervention group. Primary endpoints are change from baseline to after intervention in posture and gait. Outcomes are collected at baseline, midpoint, post, 1-month follow-up, and 6-month follow-up. Secondary and tertiary outcomes include clinical and biomechanical tests of function and questionnaires used to compliment primary outcome measures. Linear mixed models will be used to model changes in postural, biomechanical, and PROs. The primary estimand will be the contrast representing the difference in mean change in outcome measure from baseline to week 8 between treatment groups.

Discussion
The scientific premise of this study is that NDT-Tango stands to achieve more gains than PA practice alone through combining PA with MBM and social engagement. Our findings may lead to a safe non-pharmacologic intervention that improves CIN-related deficits.

Trial registration
This trial was first posted on 11/09/21 at ClinicalTrials.gov under the identifier NCT05114005.
Robust beamforming design for UAV communications based on integrated sensing and communication
Authors: Zhang Haolin , Yang Tao , Wu Xiaofeng , Guo Ziyu , Hu Bo 
Published: September 2023

AbstractIntegrated sensing and communication (ISAC) has been a promising technique in various wireless communication applications. In this paper, we investigate a beamforming design method based on ISAC waveforms in unmanned aerial vehicle (UAV) communications. An integrated state prediction and beamforming design framework is presented. We utilize the target states from sensing algorithms to improve the prediction performance. Based on the predicted states, we formulate the mathematical form of the communication interruption probability. To enhance the beamforming performance, we propose a design approach that satisfies both sensing and communication metrics and the communication interruption constraints. We show that the proposed method achieves robust communication under the integrated state prediction and beamforming design framework. Simulation results show that by using the ISAC signal, our method significantly lowers the communication interruption probability in the beamforming process and achieves better communication performance.
Timing and threshold of high sensitive troponin T measurement for the prediction of mortality after cardiac surgery: a retrospective cohort analysis
Authors: Koköfer Andreas , Cozowicz Crispiana , Wernly Bernhard , Rodemund Niklas 
Published: September 2023

Abstract
Background
High sensitive cardiac troponin T (hsTnT) is a widely used biomarker of myocardial injury. Along with other high sensitive troponins, HsTnT can predict mortality in both cardiac and non-cardiac surgery. The aim of this study was to determine the association between hsTnT serum elevations in the immediate postoperative period until 120 h after cardiac surgery and the occurrence of in‐hospital mortality compared to the Simplified Acute Physiology Score 3 (SAPS3). Additionally, we identified an ideal hsTnT serum threshold to predict in‐hospital mortality.

Methods
We performed a retrospective single-institutional cohort analysis of 2179 patients undergoing cardiac surgery with cardiopulmonary bypass from 2013 to 2021. Logistic regression analysis was used to investigate an association of hsTnT at various time points and in-hospital mortality. The model was adjusted for relevant covariates including SAPS3, lactate and administered norepinephrine dosage. ROC analysis was performed to estimate the accuracy to predict mortality by serum hsTnT concentrations. This prediction was compared to the SAPS3 score. An ideal cutoff of hsTnT concentration was calculated by means of Youden index.

Results
In total 7576 troponins were measured at the predefined timepoints. 100 (4.59%) patients died during the hospital stay. The fourth hsTnT on d3 (at 96–120 h postoperatively) showed the highest association with in-hospital death (OR 1.56; 95% CI (1.39–1.76); p < 0.001). This finding persisted after multivariable adjustment (aOR 1.34; 95% CI (1.18–1.53); p < 0.001). In contrast, the third hsTnT on d2 (at 48–72 h postoperatively) showed the best discrimination for in-hospital mortality (AUC 82.75%; 95% CI (0.77–0.89). The prediction by the third hsTnT was comparable to the in-hospital mortality prediction by SAPS3 (AUC 79.36%; 95% CI (0.73–0.85); p = 0.056). The optimal cutoff for the third hsTnT was calculated to be 1264 ng/L (Sensitivity 0.62; Specificity 0.88).

Conclusion
Elevated hsTnT after cardiac surgery was associated with an increased risk of in-hospital mortality. HsTnT measured on postoperative day 2 and 3 were most accurate to predict in-hospital mortality. The prediction of in-hospital mortality using hsTNT is comparable to mortality prediction using the SAPS3 score. HsTnT serum levels currently recommended to establish clinically important periprocedural myocardial injury are lower than thresholds identified in this study.
Thymic Hyperplasia and Graves Disease: A Nonincidental Association
Authors: Pla Peris Begoña , Abellán Galiana Pablo , Maravall Royo Francisco Javier , Merchante Alfaro Agustín Ángel 
Published: September 2023

Abstract
We present 2 cases referred for evaluation of Graves disease (GD) associated with an incidental mediastinal mass. Chest computed tomography (CT) scans showed a 1.2 × 2.4 × 4.3 cm and a 5.7 × 2.6 × 7 cm thymic enlargement, respectively, consistent with thymic hyperplasia (TH) in the 2 patients. Patient 1 had been assessed by thoracic surgery for the mediastinal mass, and thymectomy had been performed to exclude thymoma, with an anatomopathological diagnosis consistent with thymic hyperplasia. Patient 2 was treated with methimazole. CT scan was repeated after he maintained a euthyroid state, which revealed total regression of the mass. There is a well-documented association between these 2 entities, but it is often underdiagnosed and unrecognized in routine clinal practice. The benign evolution, as evidenced by regression of thymic hyperplasia after resolution of the hyperthyroidism, is characteristic. These cases highlight the importance of recognizing the association of GD and TH and warrant a conservative approach, preventing unnecessary thymic evaluation and surgery.
Calibrated microphone array recordings reveal that a gleaning bat emits low-intensity echolocation calls even in open-space habitat
Authors: de Framond Léna , Beleyur Thejasvi , Lewanzik Daniel , Goerlitz Holger R. 
Published: September 2023

ABSTRACT
Echolocating bats use ultrasound for orientation and prey capture in darkness. Ultrasound is strongly attenuated in air. Consequently, aerial-hawking bats generally emit very intense echolocation calls to maximize detection range. However, call levels vary more than tenfold (&gt;20 dB) between species and are tightly linked to the foraging strategy. The brown long-eared bat (Plecotus auritus) is a primarily gleaning, low-amplitude species that may occasionally hawk airborne prey. We used state-of-the-art calibrated acoustic 3D-localization and automated call analysis to measure P. auritus’ source levels. Plecotus auritus emits echolocation calls of low amplitude (92 dB rmsSPL re. 20 µPa at 10 cm) even while flying in open-space. While P. auritus thus probably benefits from delayed evasive manoeuvres of eared insects, we propose that low-amplitude echolocation did not evolve as an adaptive countermeasure, but is limited by morphological constraints.
Therapeutic relationship elements and therapy session outcomes: Protocol for a longitudinal study of the patient’s perspective.
Authors: Stefana Alberto , Fusar-Poli Paolo , Vieta Eduard , Youngstrom Eric A. 
Published: September 2023

Background: There is a growing recognition of the key role of the therapeutic relationship in the outcomes of psychotherapy. However, current understanding of its specific components, their interplay and related patient-therapist dynamics is limited. Objective: (a) To validate two self-report measures to assess subjective affective reactions of patients toward their psychotherapists during specific therapy sessions, and (b) to explore the relationships and dynamics among four elements of the therapeutic relationship: patient reactions toward the therapist, working alliance, alliance ruptures and repairs, and the real relationship. Methods: This study uses a nonrandomized, two-time point longitudinal design. The target population is adult patients currently engaged in individual psychotherapy for heterogeneous mental conditions. Participants are recruited through two online recruitment platforms: Research for Me and ResearchMatch. Data collection involves administering two surveys through the Qualtrics online survey platform. The baseline survey assesses information about the most recent therapy session and the preceding week, while the follow-up survey collects data on the subsequent therapy session and the days leading up to it. Discussion: This research offers three main contributions: (a) it furthers evidence-based assessment in psychotherapy by creating and validating two novel, succinct self-report tools; (b) it enhances theoretical understanding within therapeutic relationship research by exploring the significant impact of patients' perceptions of relationship elements on session outcomes variability; and (c) it will identify therapeutic relationship elements that can either enhance or hinder the overall relationship quality and session outcomes. Ethics and dissemination: The study protocol was approved by the Institutional Review Board of the University of North Carolina at Chapel Hill. The results will be published in indexed peer-reviewed journals and presented at relevant psychology and psychiatry conferences.
Truncated Balancing Policy for Perishable Inventory Management: Combating High Shortage Penalties
Authors: Zhang Can , Ayer Turgay , White Chelsea C. 
Published: September 2023

Problem definition: Motivated by a platelet inventory management problem, we study a fixed lifetime perishable inventory management problem under a general demand process. Determining an optimal ordering policy for perishable inventory systems is particularly challenging because of the well-known “curse of dimensionality.” Approximation policies with worst-case performance bounds have been developed in the literature for perishable inventory systems. However, using real data, we observe that the existing policies tend to underorder when the unit shortage penalty is high, which is an important concern for critical perishable products, such as lifesaving blood products. We seek to address this problem in this paper. Methodology/results: We present a new approximation policy for perishable inventory systems, which we call a truncated balancing (TB) policy. In particular, we first define a new balancing ordering quantity and prove a novel lower bound on the optimal ordering quantity. We then define our TB policy such that the maximum between the balancing ordering quantity and the lower bound is ordered at each period. We prove that when first in, first out is an optimal issuing policy, (1) our proposed TB policy admits a worst-case performance bound of two, and (2) it is asymptotically optimal when the unit shortage penalty goes to infinity. Finally, we present a calibrated numerical study based on real data from our partner hospital and show that our proposed policy performs significantly better than the existing policies in practical scenarios with reasonably high shortage penalties. Managerial implications: Our analysis offers managerial insights for perishable inventory management, especially for systems with an imbalance in underage and overage cost parameters. When the unit shortage penalty is high, simply balancing the underage and overage costs can lead to underordering, whereas our proposed policy effectively addresses this drawback. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0644 .