bluuebunny/crossref_metadata_2025_split huggingface dataset:
Public health intelligence challenges for local public health authorities responding to disease outbreaks: a mixed-methods systematic review protocol
Authors: Parr Janette , Chen Yen-Fu , Damery Sarah , Grove Amy 
Published: July 2023

Background: Information management capacity is crucial for controlling risks from health emergencies. But little is known about how sub-national public health bodies overcome public health intelligence challenges when responding to disease outbreaks. This paper describes a protocol for a mixed-methods systematic review to fill this knowledge gap. In addition to describing the evidence base and characterising public health intelligence responses, it will explore reported facilitators and barriers to response. Methods: Research on sub-national public health intelligence disease outbreak responses will be synthesised. The review will be limited to articles published in English, during or after 2019. Key electronic databases will be searched for peer-reviewed, primary research studies. Two reviewers will independently screen articles for relevance. Articles that refer to a public health intelligence response to a propagated disease outbreak by a sub-national Public Health Authority will be included. Quality assessment of included articles will be undertaken using published tools. Data integration will be by the Pillar Integration Process (PIP). Discussion: This review will describe and synthesise the recent literature on sub-national Public Health Authorities’ responses to propagated disease outbreaks. The systematic design will limit bias and the inclusion of data from quantitative, qualitative and mixed-methods studies will ensure relevant evidence is considered regardless of the methodology used to produce it. The review is part of a larger research project which aims to explore the role of sub-national Public Health Intelligence during the COVID-19 pandemic and investigate how public health intelligence preparedness could be improved in the future. This could provide information to support the development of training, preparedness indicators and/or ways of implementing directives. PROSPERO registration: CRD42022308042 (08/02/2022)
Pengaruh Lingkungan Kerja terhadap Work Engagement Melalui Motivasi Intrinsik Dosen
Authors: Muchtadin  
Published: July 2023

Penelitian ini bertujuan mengetahui seberapa besar lingkungan kerja berdampak terhadap work engagement melalui motivasi intrinsik. Sampel penelitian berjumlah 73 orang dosen. Pengambilan sampel dilakukan di Indonesia melalui purposive sampling dengan kriteria yaitu dosen. Data dianalisa menggunakan PLS-SEM. Hasil penelitian menemukan bahwa lingkungan kerja berpengaruh positif signifikan terhadap motivasi intrinsik dan juga work engagement. Motivasi intrinsik ditemukan memediasi pengaruh lingkungan kerja terhadap work engagement. Penelitian ini berkontribusi pada peningkatan work engagement melalui motivasi intrinsik dan lingkungan kerja pada dosen di program studi terakreditasi Baik Sekali di Indonesia.
The socioeconomic context of stigma: examining the relationship between economic conditions and attitudes towards people with mental illness across European countries
Authors: Pybus Katie , Pickett Kate E. , Lloyd Charlie , Wilkinson Richard 
Published: July 2023

IntroductionEfforts to reduce the stigma associated with mental illness have intensified over the past 30 years with a particular focus on improving public attitudes. Difficult economic circumstances can be harmful to intergroup relations, but little is known about whether there is a relationship between socioeconomic conditions and attitudes towards people with mental illnesses.MethodsRandom effects logistic regression modelling was employed to explore the relationship between individual financial circumstances, contextual socioeconomic factors and difficulty speaking to a person with a significant mental illness across European countries.ResultsLower GDP per capita and higher income inequality at the country level, alongside individual financial difficulties, were each associated with a greater likelihood of reporting difficulty speaking to a person with a significant mental illness.DiscussionMicro and macro-economic factors are associated with public attitudes towards people with mental illness across Europe. With prolonged economic instability predicted over the coming years in Europe it is important that these findings are taken into consideration when designing mental health and social policies, in order to safeguard the progress that has been made in reducing mental health stigma to date.
Assessing causal relationships between gut microbiota and asthma: evidence from two sample Mendelian randomization analysis
Authors: Li Rong , Guo Qi , Zhao Jian , Kang Wenhui , Lu Ruoyu , Long Zichong , Huang Lili , Chen Yiting , Zhao Anda , Wu Jinhong , Yin Yong , Li Shenghui 
Published: July 2023

BackgroundAccumulating evidence has suggested that gut microbiota dysbiosis is commonly observed in asthmatics. However, it remains unclear whether dysbiosis is a cause or consequence of asthma. We aimed to examine the genetic causal relationships of gut microbiota with asthma and its three phenotypes, including adult-onset asthma, childhood-onset asthma, and moderate-severe asthma.MethodsTo elucidate the causality of gut microbiota with asthma, we applied two sample Mendelian randomization (MR) based on the largest publicly available genome-wide association study (GWAS) summary statistics. Inverse variance weighting meta-analysis (IVW) was used to obtain the main estimates; and Weighted median, MR-Egger, Robust Adjusted Profile Score (MR-RAPS), Maximum likelihood method (ML), and MR pleiotropy residual sum and outlier (MR-PRESSO) methods were applied in sensitivity analyses. Finally, a reverse MR analysis was performed to evaluate the possibility of reverse causation.ResultsIn the absence of heterogeneity and horizontal pleiotropy, the IVW method revealed that genetically predicted Barnesiella and RuminococcaceaeUCG014 were positively correlated with the risk of asthma, while the association between genetically predicted CandidatusSoleaferrea and asthma was negative. And for the three phenotypes of asthma, genetically predicted Akkermansia reduced the risk of adult-onset asthma, Collinsella and RuminococcaceaeUCG014 increased the risk of childhood-onset asthma, and FamilyXIIIAD3011group, Eisenbergiella, and Ruminiclostridium6 were correlated with the risk of moderate-severe asthma (all P&lt;0.05). The reverse MR analysis didn’t find evidence supporting the reverse causality from asthma and its three phenotypes to the gut microbiota genus.ConclusionThis study suggested that microbial genera were causally associated with asthma as well as its three phenotypes. The findings deepened our understanding of the role of gut microbiota in the pathology of asthma, which emphasizes the potential of opening up a new vista for the prevention and diagnosis of asthma.
Distribution and clinical significance of anti-carbamylation protein antibodies in rheumatological diseases among the Chinese Han population
Authors: Dong Rongrong , Sun Yuanyuan , Xu Wei , Xiang Weizhen , Li Meiqi , Yang Qingrui , Zhu Ling , Ma Zhenzhen 
Published: July 2023

ObjectiveSeveral studies have demonstrated that anti-carbamylation protein antibodies (Anti-CarPA) are persistent in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSC), primary Sjögren’s syndrome (pSS), and interstitial lung disease associated with RA (RA-ILD). However, the relationship between anti-CarPA and other rheumatic diseases (RDs) and non-RA-ILD is not known till now. This study sought to examine the presence of anti-CarPA in Chinese Han patients with RDs and its clinical significance.MethodsThe study included 90 healthy controls (HCs) and 300 patients with RDs, including RA, SLE, polymyositis/dermatomyositis (PM/DM), pSS, SSC, spondyloarthritis (SpA), anti-neutrophil cytoplasmic autoantibodies associated with vasculitis (AAV), undifferentiated connective tissue disease (UCTD), and Behcet’s disease (BD). Antibodies against carbamylated human serum albumin were detected using commercial enzyme-linked immunosorbent assay kits. Correlations between clinical and laboratory parameters were analyzed.ResultSerum levels of anti-CarPA in RA (34.43 ± 33.34 ng/ml), SLE (21.12 ± 22.23 ng/ml), pSS (16.32 ± 13.54 ng/ml), PM/DM (30.85 ± 17.34 ng/ml), SSC (23.53 ± 10.70 ng/ml), and UCTD (28.35 ± 21.91 ng/ml) were higher than those of anti-CarPA in the HCs (7.30 ± 5.05 ng/ml). The concentration of serum anti-CarPA was higher in patients with rheumatic disease-related interstitial lung disease (RD-ILD), especially RA-ILD, PM/DM-ILD, and pSS-ILD. Patients with RD-ILD who tested positive for anti-CarPA were more likely to have a more severe radiographic classification (grades II, p = 0.045; grades III, p = 0.003). Binary logistic regression analysis suggested that anti-CarPA had an association with ILD in RA (p = 0.033), PM/DM (p = 0.039), and pSS (p = 0.048). Based on receiver operating characteristics (ROC) analysis, anti-CarPA cutoffs best discriminated ILD in RA (&gt;32.59 ng/ml, p = 0.050), PM/DM (&gt;23.46 ng/ml, p = 0.038), and pSS (&gt;37.08 ng/ml, p = 0.040). Moreover, serum levels of anti-CarPA were correlated with antibodies against transcription intermediary factor 1 complex (anti-TIF1) (R = –0.28, p = 0.044), antibodies against glycyl-transfer ribonucleic acid synthetase (anti-EJ) (R = 0.30, p = 0.031), and antibodies against melanoma differentiation-associated gene 5 (anti-MDA5) (R = 0.35, p = 0.011).ConclusionSerum anti-CarPA could be detected in patients with RA, PM/DM, pSS, SSC, and UCTD among the Chinese Han population. And it may also assist in identifying ILD in patients with RA, PM/DM, and pSS, which emphasized attention to the lung involvement in anti-CarPA-positive patients.
Brain network characteristics between subacute and chronic stroke survivors in active, imagery, passive movement task: a pilot study
Authors: Lin Yifang , Jiang Zewu , Zhan Gege , Su Haolong , Kang XiaoYang , Jia Jie 
Published: July 2023

BackgroundThe activation patterns and functional network characteristics between stroke survivors and healthy individuals based on resting-or task-state neuroimaging and neurophysiological techniques have been extensively explored. However, the discrepancy between stroke patients at different recovery stages remains unclear.ObjectiveTo investigate the changes in brain connectivity and network topology between subacute and chronic patients, and hope to provide a basis for rehabilitation strategies at different stages after stroke.MethodsFifteen stroke survivors were assigned to the subacute group (SG, N = 9) and chronic group (CG, N = 6). They were asked to perform hand grasping under active, passive, and MI conditions when recording EEG. The Fugl-Meyer Assessment Upper Extremity subscale (FMA_UE), modified Ashworth Scale (MAS), Manual Muscle Test (MMT), grip and pinch strength, modified Barthel Index (MBI), and Berg Balance Scale (BBS) were measured.ResultsFunctional connectivity analyses showed significant interactions on frontal, parietal and occipital lobes connections in each frequency band, particularly in the delta band. The coupling strength of premotor cortex, M1, S1 and several connections linked to frontal, parietal, and occipital lobes in subacute subjects were lower than in chronic subjects in low alpha, high alpha, low beta, and high beta bands. Nodal clustering coefficient (CC) analyses revealed that the CC in chronic subjects was higher than in subacute subjects in the ipsilesional S1 and occipital area, contralesional dorsolateral prefrontal cortex and parietal area. Characteristic path length (CPL) analyses showed that CPL in subacute subjects was lower than in chronic subjects in low beta, high beta, and gamma bands. There were no significant differences between subacute and chronic subjects for small-world property.ConclusionSubacute stroke survivors were characterized by higher transfer efficiency of the entire brain network and weak local nodal effects. Transfer efficiency was reduced, the local nodal role was strengthened, and more neural resources needed to be mobilized to perform motor tasks for chronic survivors. Overall, these results may help to understand the remodeling pattern of the brain network for different post-stroke stages on task conditions and the mechanism of spontaneous recovery.
Digestive α-L-fucosidase activity in Rhodnius prolixus after blood feeding: effect of secretagogue and nutritional stimuli
Authors: Gama Maiara do Valle Faria , Alexandre Yasmim do Nascimento , Pereira da Silva João Mario , Castro Daniele Pereira , Genta Fernando Ariel 
Published: July 2023

Introduction:Rhodnius prolixus (Hemiptera: Reduviidae) is an important vector of Trypanosoma cruzi, the causative agent of Chagas Disease. This insect is a model for the study of insect physiology, especially concerning the digestion of blood. Among the enzymes produced in the midgut of R. prolixus after blood feeding there is a α-L-fucosidase activity. There are very few studies on α-L-fucosidase of insects, and the role of R. prolixus α-L-fucosidase is still not clear. In this work, we tested if the mechanism for production of this enzyme is similar to the observed for proteases, a secretatogue mechanism that respond to the protein contents of the meal.Methods: We tested if specific proteins or sugars elicit this response, which may help to understand the nature of the physiological substrate for this enzyme.Results: In general, our results showed that the Anterior Midgut was the only midgut fraction that responds to the blood meal in terms of α-L-fucosidase production. Besides that, this response was not triggered by midgut distension or by ingestion of the blood cell fraction. Conversely, the enzyme was produced after feeding with the plasma fraction. However, the production of α-L-fucosidase was also triggered by different biochemical stimuli, as protein or fucoidan ingestion.Discussion: This suggested that the production of the enzyme in the anterior midgut was a general physiological response under control of different convergent signals. Besides that, the comparison between different treatments for artificial blood feeding showed that heparinated blood was the choice with minor side effects for the study of the midgut α-L-fucosidase, when compared to defibrinated or citrated blood.
Plant Height and Stem Diameter of Solanum quitoense Lamarck Improved with Applications of AMF and Biostimulants
Authors: Olguín-Hernández Ana Laura , Arévalo-Galarza Ma. de Lourdes , Cadena-Iñiguez Jorge , Jaén-Contreras David , Peña-Valdivia Cecilia B. 
Published: July 2023

The lulo plant (Solanum quitoense Lamarck) is native to South America. In Mexico, this species shows potential for the conversion of agroecosystems. It is used as food and pharmaceutical sources for metabolites. However, there are few papers related to how this species can grow under conditions outside of the Andean countries (Bolivia, Colombia, Ecuador, and Peru). The objective of this research was to evaluate the development of lulo under cloud forest conditions and the effect of inoculating the plant with mycorrhizae (Funneliformis mosseae (T. H. Nicolson and Gerd.) C. Walker and A. Schüssler, and Entrophospora colombiana Spain and N. C. Schenck) and diammonium phosphate (DAP: NPK 18-46-00) fertilization. The plant growth, leaf area, mycorrhizal colonization, and leaf mineral content were evaluated from transplant to fruit formation. The experiment was conducted under field conditions in volcanic soils (clayey Vertisol) in a cloud forest. The inoculation of E. colombiana was 86.19% of the colonization, and the content of N, K, Ca, Mg, Mn, Cu, Zn, and Fe in the leaves was the higher in these plants. The highest P content was obtained from the DAP treatment and the height of the plant was 11.8% and 12.5% in the treatments using DAP and E. colombiana, respectively. The plant growth was significantly higher in the plants inoculated with E. colombiana followed by DAP. The plants inoculated with F. mosseae registered lower values than the control. Lulo plants grow in the climate and soils of volcanic origin of the cloud forest. The results showed that AMF colonization was beneficial and outperformed the native strains. The results are new for the introduced lulo plants in Mexico and can help reduce the learning path for commercial cultivation.
A eficácia do uso da heparina na prevenção de tromboembolismo venoso em pacientes acometidos por COVID-19: revisão sistemática
Authors: Candido Antonia Camila Monteiro , Bezerra Felipe Grana , De Almeida Patrícia Souza , De Almeida Anne Cristine Gomes , Brito Marcelo Augusto Mota , Chagas Kadmiel Cândido 
Published: July 2023

INTRODUÇÃO: A Heparina de baixo peso molecular e heparina não fracionada possuem propriedades antiinflamatórias, sendo comumente utilizada associação com agentes antiplaquetários no tratamento das síndromes coronarianas agudas e na prevenção de tromboembolismo venoso. OBJETIVO: Avaliar a eficácia do uso da heparina na prevenção de tromboembolismo venoso em pacientes acometidos por COVID-19. MÉTODOS: Trata-se de uma Revisão Sistemática. Os artigos foram selecionados a partir das bibliotecas virtuais SCIELO, BVS e PubMed. Os critérios de inclusão foram publicações de 2019 a 2022, com idiomas ou português ou inglês, texto completo, disponibilizados gratuitamente e que atendessem as questões e aos objetivos da pesquisa. Foram excluídos estudos duplicados nas referidas bibliotecas virtuais, fora do período mencionado, e que não atendiam objetivos da pesquisa. RESULTADOS: Foram incluídos 15 artigos para compor esta revisão sistemática. Observou-se que o uso das heparinas de baixo peso molecular ou heparinas não fracionadas, é recomendado como uso profilático em pacientes hospitalizados ou não, visando prevenir a tromboembolia venosa. Porém, o uso de uma dose profilática intermediária ou de intervenção profilática pós-alta foi associada a melhoras da coagolação e por isso se recomenda o uso de anticoagulação profilática durante a hospitalização. CONCLUSÕES: Com base nos achados podemos dizer que o uso de Heparinas de Baixo Peso Molecular e Heparina Não Fracionada em doses profiláticas e terapêuticas é indicado pois demonstrou benefício clínico e baixo risco de complicações hemorrágicas. Dessa forma, concluímos que existe elevado risco de TEV em pacientes acometidos por COVID-19 e que a profilaxia com o uso de heparina pode ser realizada nos pacientes considerando seu quadro clínico.
Diseño de interfaz gráficas de usuario para el análisis, diseño, simulación y control de sistemas lineales análisis de sistemas lineales utilizando Matlab
Authors: Sosa Lais Hernández , González Antonio Ochoa , Aciego Carlos Ernesto Díaz , Álvarez Ernesto Pérez , Marín Juan Anzurez , Zavala Salvador Ramírez 
Published: July 2023

La mayoría de los sistemas físicos pueden representarse con modelos lineales o linealizarse para un mejor análisis, diseño e implementación; en el área de control y automatización de procesos resulta de gran importancia y utilidad analizar las características principales de los sistemas lineales, así en el presente trabajo se implementa una aplicación basada en una interfaz gráfica que permite analizarlos, en características como estabilidad, controlabilidad, observabilidad, respuesta en lazo abierto y diseño del controlador/observador cuando el sistema cumpla con las condiciones. Estos aspectos podrían obtenerse directamente mediante las funciones implementadas en el software Matlab®; sin embargo, se requiere conocer y dominar los comandos y la forma necesaria para introducir los datos, por lo que en esta aplicación las funciones se ejecutan internamente sólo presionando botones, permitiendo la introducción de los datos de manera matricial y ofreciendo los resultados de forma clara e intuitiva mediante gráficos y valores explicados. La interfaz diseñada se puede ejecutar en cualquier computadora sin necesidad de tener dicho software instalado.
Mineração de Processos como Ferramenta para Promoção da Transparência: Oportunidades e Desafios
Authors: Mendes de Araujo Renata , Marques Peres Sarajane , Fantinato Marcelo , Jacoto Unger Adriana , Rodrigues Neubauer Thais 
Published: July 2023

A transparência pública possibilita o exercício da democracia tanto pela orientação a melhores práticas de gestão por parte das instituições públicas como pela promoção da participação ativa dos cidadãos na gestão pública. A transparência é uma conduta essencial em um contexto democrático e sua prática deve ser continuamente incentivada e aperfeiçoada, principalmente considerando as possibilidades que emergem de novas tecnologias, incluindo as tecnologias relacionadas à gestão da informação. Neste ensaio, exploramos o potencial da mineração de processos como um agente tecnológico de apoio à transparência pública. A capacidade da mineração de processos em possibilitar a análise visual e analítica dos dados relacionados aos registros de execução de processos no âmbito da administração pública, bem como sua capacidade de permitir modelagem preditiva e prescritiva, traz oportunidades para o entendimento do funcionamento da máquina pública, para monitoramento e análise de seu desempenho, incluindo a proposição de ações para otimização do processo e para verificação de conformidade com normativas, por parte tanto de órgãos de controle como também dos cidadãos. Nós discutimos oportunidades de uso da mineração de processos para promoção da transparência pública a partir de estudos exploratórios anteriores em dois contextos: na área da saúde (considerando o processo de gestão de produtos de saúde da agência de vigilância sanitária nacional) e na área jurídica (considerando a tramitação de processos jurídicos no maior tribunal do Brasil). Reconhecendo, ainda, que tecnologias são ferramentas paradoxais que trazem tanto facilidades como incongruências, discutimos alguns potenciais desafios para a adoção da mineração de processos para a transparência na administração pública observados a partir dos estudos.