bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal MRI: From Nephron to NMR Signal
Authors: Bane Octavia , Seeliger Erdmann , Cox Eleanor , Stabinska Julia , Bechler Eric , Lewis Sara , Hickson LaTonya J. , Francis Sue , Sigmund Eric , Niendorf Thoralf 
Published: May 2023

Renal diseases pose a significant socio‐economic burden on healthcare systems. The development of better diagnostics and prognostics is well‐recognized as a key strategy to resolve these challenges. Central to these developments are MRI biomarkers, due to their potential for monitoring of early pathophysiological changes, renal disease progression or treatment effects. The surge in renal MRI involves major cross‐domain initiatives, large clinical studies, and educational programs. In parallel with these translational efforts, the need for greater (patho)physiological specificity remains, to enable engagement with clinical nephrologists and increase the associated health impact. The ISMRM 2022 Member Initiated Symposium (MIS) on renal MRI spotlighted this issue with the goal of inspiring more solutions from the ISMRM community. This work is a summary of the MIS presentations devoted to: 1) educating imaging scientists and clinicians on renal (patho)physiology and demands from clinical nephrologists, 2) elucidating the connection of MRI parameters with renal physiology, 3) presenting the current state of leading MR surrogates in assessing renal structure and functions as well as their next generation of innovation, and 4) describing the potential of these imaging markers for providing clinically meaningful renal characterization to guide or supplement clinical decision making. We hope to continue momentum of recent years and introduce new entrants to the development process, connecting (patho)physiology with (bio)physics, and conceiving new clinical applications. We envision this process to benefit from cross‐disciplinary collaboration and analogous efforts in other body organs, but also to maximally leverage the unique opportunities of renal physiology.Level of Evidence1Technical Efficacy Stage2
What Makes Children's Responses to Creativity Assessments Difficult to Judge Reliably?
Authors: Dumas Denis , Acar Selcuk , Berthiaume Kelly , Organisciak Peter , Eby David , Grajzel Katalin , Vlaamster Theadora , Newman Michele , Carrera Melanie 
Published: May 2023

ABSTRACTOpen‐ended verbal creativity assessments are commonly administered in psychological research and in educational practice to elementary‐aged children. Children's responses are then typically rated by teams of judges who are trained to identify original ideas, hopefully with a degree of inter‐rater agreement. Even in cases where the judges are reliable, some residual disagreement on the originality of the responses is inevitable. Here, we modeled the predictors of inter‐rater disagreement in a large (i.e., 387 elementary school students and 10,449 individual item responses) dataset of children's creativity assessment responses. Our five trained judges rated the responses with a high degree of consistency reliability (α = 0.844), but we undertook this study to predict the residual disagreement. We used an adaptive LASSO model to predict 72% of the variance in our judges' residual disagreement and found that there were certain types of responses on which our judges tended to disagree more. The main effects in our model showed that responses that were less original, more elaborate, prompted by a Uses task, from younger children, or from male students, were all more difficult for the judges to rate reliably. Among the interaction effects, we found that our judges were also more likely to disagree on highly original responses from Gifted/Talented students, responses from Latinx students who were identified as English Language Learners, or responses from Asian students who took a lot of time on the task. Given that human judgments such as these are currently being used to train artificial intelligence systems to rate responses to creativity assessments, we believe understanding their nuances is important.
Effects of tamarind seed polysaccharides on physicochemical characteristics of frozen dough: structure–function relationship
Authors: Ren Xiaolong , Zheng Weiqi , Li Lin , Feng Shuo , Zhang Hui , Xiong Zhiqiang , Wu Yan , Song Zibo , Ai Lianzhong , Xie Fan 
Published: May 2023

AbstractBACKGROUNDRecently, frozen dough has become more popular because of its ability to be quickly transformed into freshly baked foods. During the storage and transport process, frozen dough can suffer some degree of damage caused by ice crystallization and recrystallization. Adding polysaccharides to frozen dough is a good way to solve this problem. Tamarind seed polysaccharide (TSP) has excellent ice crystal steady ability and has also been widely used in frozen foods. However, there is no study on the use of TSP in frozen dough.RESULTSTSP can stabilize the bound water content, inhibit the freezable water content, and increase elasticity. However, the dough with different structures of TSP added was less firm after 30 days of freezing compared to the dough without TSP, and the porosity and stomatal density of the prepared steamed bread gradually decreased. The addition of TSP reduced gluten deterioration during the freezing process, thus decreasing the collapse and uneven porosity of the steamed bread.CONCLUSIONSThe results could provide new insights into the structure of TSP and its effect on the quality characteristics of frozen dough. © 2023 Society of Chemical Industry.
The Coral Bleaching Automated Stress System (CBASS): A low‐cost, portable system for standardized empirical assessments of coral thermal limits
Authors: Evensen Nicolas R. , Parker Katherine E. , Oliver Thomas A. , Palumbi Stephen R. , Logan Cheryl A. , Ryan James S. , Klepac Courtney N. , Perna Gabriela , Warner Mark E. , Voolstra Christian R. , Barshis Daniel J. 
Published: May 2023

AbstractOcean warming is increasingly affecting marine ecosystems across the globe. Reef‐building corals are particularly affected by warming, with mass bleaching events increasing in frequency and leading to widespread coral mortality. Yet, some corals can resist or recover from bleaching better than others. Such variability in thermal resilience could be critical to reef persistence; however, the scientific community lacks standardized diagnostic approaches to rapidly and comparatively assess coral thermal vulnerability prior to bleaching events. We present the Coral Bleaching Automated Stress System (CBASS) as a low‐cost, open‐source, field‐portable experimental system for rapid empirical assessment of coral thermal thresholds using standardized temperature stress profiles and diagnostics. The CBASS consists of four or eight flow‐through experimental aquaria with independent water masses, lighting, and individual automated temperature controls capable of delivering custom modulating thermal profiles. The CBASS is used to conduct daily thermal stress exposures that typically include 3‐h temperature ramps to multiple target temperatures, a 3‐h hold period at the target temperatures, and a 1‐h ramp back down to ambient temperature, followed by an overnight recovery period. This mimics shallow water temperature profiles observed in coral reefs and prompts a rapid acute heat stress response that can serve as a diagnostic tool to identify putative thermotolerant corals for in‐depth assessments of adaptation mechanisms, targeted conservation, and possible use in restoration efforts. The CBASS is deployable within hours and can assay up to 40 coral fragments/aquaria/day, enabling high‐throughput, rapid determination of thermal thresholds for individual genotypes, populations, species, and sites using a standardized experimental framework.
Multifunctional Fluorinated Lubricant‐Infused Poly(4‐Hydroxybutyrate) (P4HB) Membranes for Full‐Thickness Abdominal Wall Defect Repair
Authors: Sun Xiuxia , Chen Qi , Guan Angelique A. , Yuan Shuaishuai , Li Zhibo 
Published: May 2023

AbstractAbdominal wall defect caused by surgical trauma, congenital rupture, or tumor resection may result in hernia formation or even death. Tension‐free abdominal wall defect repair by using patches is the gold standard to solve such problems. However, adhesions following patch implantation remain one of the most challenging issues in surgical practice. The development of new kinds of barriers is key to addressing peritoneal adhesions and repairing abdominal wall defects. It is already well recognized that ideal barrier materials need to have good resistance to nonspecific protein adsorption, cell adhesion, and bacterial colonization for preventing the initial development of adhesion. Herein, electrospun poly(4‐hydroxybutyrate) (P4HB) membranes infused with perfluorocarbon oil are used as physical barriers. The oil‐infused P4HB membranes can greatly prevent protein attachment and reduce blood cell adhesion in vitro. It is further shown that the perfluorocarbon oil‐infused P4HB membranes can reduce bacterial colonization. The in vivo study reveals that perfluoro(decahydronaphthalene)‐infused P4HB membranes can significantly prevent peritoneal adhesions in the classic abdominal wall defects’ model and accelerate defect repair, as evidenced by gross examination and histological evaluation. This work provides a safe fluorinated lubricant‐impregnated P4HB physical barrier to inhibit the formation of postoperative peritoneal adhesions and efficiently repair soft‐tissue defects.
Phenolic Polymers as Model Melanins
Authors: Galeb Hanaa A. , Eichhorn Jonas , Harley Sam , Robson Alexander J. , Martocq Laurine , Nicholson Steven J. , Ashton Mark D. , Abdelmohsen Hend A. M. , Pelit Emel , Baldock Sara J. , Halcovitch Nathan R. , Robinson Benjamin J. , Schacher Felix H. , Chechik Victor , Vercruysse Koen , Taylor Adam M. , Hardy John G. 
Published: May 2023

AbstractMelanins are a class of conjugated biopolymers with varying compositions and functions, which have a variety of potential medical and technical applications. Here, this work examines the conjugated polymers derived from a variety of phenolic monomers (catechol (CAT), levodopa (DOPA), and homogentisic acid (HGA)), using a selection of different analytical chemistry techniques to compare their properties with a view to understanding structure–function relations. The polymers display measurable conductivity, with electronic properties tuned by the functional groups pendant on the polymer backbones (which served as dopants) suggesting their potential for application in electronic devices.
Syntheses of Cyclic Poly(l‐lactide)s by Means of Zinc‐Based Ring‐Opening Polymerization with Simultaneous Polycondensation (ROPPOC) Catalysts
Authors: Kricheldorf Hans R. , Scheliga Felix , Weidner Steffen M. 
Published: May 2023

AbstractRing‐opening polymerizations of l‐lactide are studied in bulk at 140 or 160 °C with zinc n‐hexanoate, zinc 4‐chlorothiophenolate, and zinc pentafluoro thiophenolate (ZnSPF) as catalysts. The reactivity increases in the given order. With all three catalysts a high fraction of cycles is obtained only at polymerization (annealing) times around 7 d. With ZnSPF weight average molecular weights (Mw) up to 178 000, a Tm around 199 °C and a ΔHm around 99 J g−1 w
ere achieved. The samples annealed for 4 or 7 d also display a saw tooth pattern of the mass peak distribution in the matrix‐assisted laser desorption/ionization time of flight spectra indicating transesterification reactions across the surface of extended ring crystals. This process optimizes the thermodynamical properties of the crystalline cyclic polylactides and is responsible for the high Tm and ΔHm values.
Incomparable Vγ$V_\gamma$‐degrees
Authors: Zhang Teng 
Published: May 2023

AbstractIn [3], Shi proved that there exist incomparable Zermelo degrees at γ if there exists an ω‐sequence of measurable cardinals, whose limit is γ. He asked whether there is a size antichain of Zermelo degrees. We consider this question for the ‐degree structure. We use a kind of Prikry‐type forcing to show that if there is an ω‐sequence of measurable cardinals, then there are ‐many pairwise incomparable ‐degrees, where γ is the limit of the ω‐sequence of measurable cardinals.
Collusion and corporate tax burden: Firm‐level evidence from China
Authors: Feng Yuanlin , Wang Fei , He Lingyun 
Published: May 2023

AbstractGovernment‐firm collusion and corporate tax avoidance will result in tax loss, which has spawned several challenges that hinder economic growth and political stability. Based on the microdata of the National Tax Statistics Database (NTSD) of China from 2010 to 2014, this paper estimates the impact of government‐firm collusion on corporate tax burden. Using the business entertainment expenses as a measure of collusion, we find that government‐firm collusion significantly reduces corporate tax burden and increases tax avoidance. Mechanism analysis shows that collusion reduces corporate tax burden by providing firms with preferential tax policies and weakening taxation supervision of tax authorities. In addition, we find that reaping enormous benefits is the primary motivation for government‐firm collusion. The reduction effect of collusion on tax burden will be more substantial if the parties involved can reap more benefits. If tax collectors' discretionary power is restricted, the mutual benefits will be reduced, thus making it difficult for tax officials and taxpayers to build collusive relationships.
Mitochondrial energy metabolism is downregulated in repeated implantation failure patients related to alteration of PGC‐1α acetylation level
Authors: Han Shuo , Liu Sai , Jin Nai‐Qian , Lv Ya‐Su , Yang Mo , Ma Shuai , Fu Yao , Zhao Shan‐Ke , Liu Ming‐Hui 
Published: May 2023

AbstractHerein we aimed at exploring mitochondrial energy metabolism status in patients with repeated implantation failure (RIF) and whether key regulatory factor PGC‐1α of energy metabolism is involved in the decidualization of endometrial stromal cells. Mitochondrial oxidative phosphorylation level and ATP synthesis were compared in primary endometrial stromal cells from RIF and control group. At the same time, as one of key transcription regulators of mitochondrial energy metabolism, the expression level and acetylation level of PGC‐1α were compared with two groups. Then, we downregulated the acetylation levels of PGC‐1α, and the expression of decidual markers (PRL and IGFBP1) was observed further. Mitochondrial energy metabolism, showing by mitochondrial oxidative phosphorylation level and ATP synthesis, was decreased in the endometrial stromal cells of the RIF group (RIF‐hEnSCs). Meanwhile, PGC‐1α acetylation levels were significantly higher in RIF‐hEnSCs. When we reduced the acetylation levels of PGC‐1α in RIF‐hEnSCs, the basal O2 consumption rate and maximal respiration were increased, and also the PRL and IGFBP1. Overall, our data indicated that the endometrial stromal cells of the RIF patients had low level of mitochondrial energy metabolism. Reducing acetylation level of key energy metabolism regulator PGC‐1α can increase the decidualization level of RIF‐hEnSCs. These findings may inspire new ideas about the treatment of RIF.
Biochemical and functional characterization of skeletal muscle cells differentiated from tonsil‐derived mesenchymal stem cells
Authors: Choi Yeonzi , Nam Yu Hwa , Jeong Soyeon , Lee Hee‐Yoon , Choi Se‐Young , Park Saeyoung , Jung Sung‐Chul 
Published: May 2023

AbstractIntroduction/AimsHuman tonsils are a readily accessible source of stem cells for the potential treatment of skeletal muscle disorders. We reported previously that tonsil‐derived mesenchymal stem cells (TMSCs) can differentiate into skeletal muscle cells (SKMCs), which renders TMSCs promising candidates for cell therapy for skeletal muscle disorders. However, the functional properties of the myocytes differentiated from mesenchymal stem cells have not been clearly evaluated. In this study we investigated whether myocytes differentiated from TMSCs (skeletal muscle cells derived from tonsil mesenchymal stem cells [TMSC‐SKMCs]) exhibit the functional characteristics of SKMCs.MethodsTo test the insulin reactivity of TMSC‐SKMCs, the expression of glucose transporter 4 (GLUT4) and phosphatidylinositol 3‐kinase/Akt was analyzed after the cells were treated for 30 minutes with 100 nmol/L insulin in normal or high‐glucose medium. We also examined whether these cells formed a neuromuscular junction (NMJ) when cocultured with motor neurons, and whether they were stimulated by electrical signals using whole‐cell patch clamping.ResultsSkeletal muscle cells derived from tonsil mesenchymal stem cells expressed SKMC markers, such as MYOD, MYH3, MYH8, TNNI1, and TTN, at high levels, and exhibited a multinucleated cell morphology and a myotube‐like shape. The expression of the acetylcholine receptor and GLUT4 was confirmed in TMSC‐SKMCs. In addition, these cells exhibited insulin‐mediated glucose uptake, NMJ formation, and transient changes in cell membrane action potential, all of which are representative functions of human SKMCs.DiscussionTonsil‐derived mesenchymal stem cells can be functionally differentiated into SKMCs and may have potential for clinical application for the treatment of skeletal muscle disorders.
Quality of life and associated factors among community‐dwelling adults with multimorbidity in Shanghai, China: A cross‐sectional study
Authors: Liu Xingyue , Zhang Juhua , Zhang Shixiang , Peng Shuzhi , Pei Mengyun , Dai Chunying , Wang Tingting , Zhang Peng 
Published: May 2023

AbstractAimTo compare the quality of life of patients with and without multimorbidity and investigate potential factors related to the quality of life in patients with multimorbidity.DesignA descriptive cross‐sectional study.MethodsThis study included 1778 residents with chronic diseases, including single disease (1255 people, average age: 60.78 ± 9.42) and multimorbidity (523 people, average age: 64.03 ± 8.91) groups, who were recruited from urban residents of Shanghai through a multistage, stratified, probability proportional to size sampling method. The quality of life was measured using the World Health Organization Quality of Life Questionnaire. The socio‐demographic data and psychological states were measured using a self‐made structured questionnaire, Self‐rating Anxiety Scale, and Self‐rating Depression Scale. Differences in demographic characteristics were estimated using Pearson's chi‐squared test, and independent t‐test or one‐way ANOVA followed by S‐N‐K test was used to compare the mean quality of life. Multiple linear regression analysis was conducted to identify risk factors for multimorbidity.ResultsThere were differences in age, education, income, and BMI between single‐disease and multimorbidity groups, but no differences in gender, marriage, and occupation. Multimorbidity had lower quality of life, reflected in all four domains. Multiple linear regression analyses showed that low level of education, low income, number of diseases, depression, and anxiety were negatively related to quality of life in all domains.
Feasibility of combining temsirolimus to vincristine, dactinomycin, cyclophosphamide, and vincristine and irinotecan chemotherapy for children with intermediate‐risk rhabdomyosarcoma: A report from Children's Oncology Group
Authors: Oberoi Sapna , Qumseya Amria , Xue Wei , Harrison Douglas J. , Rudzinski Erin R. , Wolden Suzanne L. , Dasgupta Roshni , Venkatramani Rajkumar , Gupta Abha A. 
Published: May 2023

AbstractBackgroundTemsirolimus has shown in vivo activity against rhabdomyosarcoma (RMS). We aimed to determine the feasibility of incorporating temsirolimus within the standard Children's Oncology Group (COG) chemotherapy backbone of vincristine, actinomycin‐D, and cyclophosphamide (VAC) alternating with vincristine and irinotecan (VI) in children with intermediate‐risk (IR) RMS.MethodsThe feasibility phase of the COG IR‐RMS trial, ARST1431 (NCT02567435), assigned 10 patients to receive 15 mg/m2/dose (dose level 1) of temsirolimus on days 1, 8, and 15 of each of three weekly VAC and VI cycles for the first 12 weeks of induction chemotherapy. The primary endpoint of the feasibility phase was to establish the safe dose and safety of combining temsirolimus with VAC/VI. The combination regimen was deemed feasible if less than 40% of patients developed a priori defined nonhematological dose‐limiting toxicities (DLTs).ResultsTen patients (seven males and three females; median age = 4.5 years [range: 0.2–14.4 years]) with IR‐RMS were enrolled and received dose level 1 of temsirolimus. Eight patients had FOXO1‐negative disease, while two had FOXO1‐positive disease. Two patients had metastatic disease. Of 10 patients, two developed DLTs: grade 3 oral mucositis and pneumonitis. Four patients (40%) had grade 4 neutropenia. No treatment‐related mortality occurred. The median duration of the completion of the feasibility phase was 12.1 weeks (range: 11.7–15 weeks).ConclusionsWeekly temsirolimus at 15 mg/m2/dose during VAC/VI chemotherapy was feasible and well tolerated. The efficacy of this regimen is currently being tested in a phase III randomized trial against VAC/VI chemotherapy alone in the ARST1431 trial.
Barriers to medication adherence in sickle cell disease: A comprehensive theory‐based evaluation using the COM‐B model
Authors: King Kathryn , Cai Stephanie , Barrera Leonardo , Reddy Paavani , Heneghan Mallorie B. , Badawy Sherif M. 
Published: May 2023

AbstractBackgroundSickle cell disease (SCD) affects more than 100,000 Americans, with complications such as pain episodes and acute chest syndrome. Despite the efficacy of hydroxyurea in reducing these complications, adherence remains low. Study objectives were to examine barriers to hydroxyurea adherence, and to evaluate the relationship between barriers and their impact on adherence.MethodsIn this cross‐sectional study, patients with SCD and their caregivers were enrolled if they were taking hydroxyurea. Study measures included demographics, self‐report of adherence using visual analog scale (VAS), and the Disease Management and Barriers Interview (DMI)‐SCD. The DMI‐SCD was mapped to the Capability, Opportunity, Motivation, and Behavior (COM‐B) model.ResultsForty‐eight caregivers (females 83%, median age 38 [34–43]) and 19 patients (male 53%, median age 15 [13.5–18]) participated. Using VAS, many patients (63%) reported low hydroxyurea adherence, while most caregivers (75%) reported high adherence. Caregivers endorsed barriers across multiple COM‐B components, with physical opportunity (e.g., cost) and reflective motivation (e.g., SCD perceptions) being the most identified categories (48% and 42%), respectively. Patients’ most identified barriers included psychological capability (e.g., forgetfulness) and reflective motivation (84% and 68%), respectively. Patients’ and caregivers’ VAS scores negatively correlated with the number of barriers (rs = –.53, p = .01; rs = –.28, p = .05) and COM‐B categories (rs = –.51, p = .02; rs = –.35, p = .01), respectively, suggesting lower adherence with more endorsed barriers.ConclusionsFewer barriers to hydroxyurea adherence were associated with higher adherence. Understanding barriers to adherence is essential to develop tailored interventions aimed at improving adherence.