bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maximum isotope accumulation in the retrosplenial cortex during amnesia attack and its temporal change suggest cortical spreading depression as a pathophysiology of patients with transient global amnesia
Authors: Watanabe Yoshio , Taniguchi Akira , Tomimoto Hidekazu 
Published: May 2023

AbstractTransient global amnesia (TGA) is a clinical syndrome that is characterized by the sudden onset of anterograde amnesia and a less prominent impairment in retrograde memory lasting up to 24 h. Although several etiologies have been proposed, including migraine, epilepsy, ischemia, venous congestion, and glutamate toxicity, none sufficiently explain the disorder in its entirety. We retrospectively investigated images obtained using single‐photon emission computed tomography (SPECT), performed with 99mtechnetium hexamethylpropyleneamine oxime, from 11 patients with TGA divided into the following groups based on the timing of SPECT: during TGA (n = 2, Group 1), at the start of the attenuation of memory impairments (n = 2, Group 2), and after TGA (n = 7, Group 3). Regional isotope accumulation was examined using a three‐dimensional stereotactic surface projection (3D‐SSP) analysis. After calculating the mathematical product of the mean severity and extent ratio, unique comparable bar graphs were prepared with respect to Brodmann's areas (B). Increases in isotope accumulation were the largest in the retrosplenial cortex (B29, B30), posterior cingulate cortex (B23, B31), and precuneus (B7) in Groups 1 and 2, whereas decreases were noted in the same regions in Group 3. This is the first study to identify cerebral sites and describe changes consistent with the completion of amnesia as a symptom using an image analysis, such as a 3D‐SSP analysis. We consider cortical spreading depression (CSD) to be the etiology of TGA based on maximum isotope accumulation in the above sites and a literature review on CSD.
The mitochondrial calcium signaling, regulation, and cellular functions: A novel target for therapeutic medicine in neurological disorders
Authors: Bagheri‐Mohammadi Saeid , Farjami Mohammad , Suha Ali Jaafari , Zarch Seyed Mohsen Aghaei , Najafi Sajad , Esmaeili Ali 
Published: May 2023

AbstractMitochondrial calcium (Ca2+) dynamics play critical roles in regulating vital physiological conditions in the brain. Importantly, Mitochondria‐associated endoplasmic reticulum (ER) membranes serve different cellular functions including Ca2+ signaling, bioenergetics, phospholipid biosynthesis, cholesterol esterification, programmed cell death, and communication between the two organelles. Several Ca2+‐transport systems specialize at the mitochondria, ER, and their contact sites that provide tight control of mitochondrial Ca2+ signaling at the molecular level. The biological function of Ca2+ channels and transporters as well as the role of mitochondrial Ca2+ signaling in cellular homeostasis can open new perspectives for investigation and molecular intervention. Emerging evidence suggests that abnormalities in ER/mitochondrial brain functions and dysregulation of Ca2+ homeostasis are neuropathological hallmarks of neurological disorders like Alzheimer's disease, but little evidence is available to demonstrate their relationship to disease pathogenesis and therapeutic approaches. In recent years, the detection of the molecular mechanism regulating cellular Ca2+ homeostasis and also mitochondrial functions have expanded the number of targeted treatments. The main experimental data identify beneficial effects, whereas some scientific trials did not meet the expectations. Together with an overview of the important function of mitochondria, this review paper introduced the possible tested therapeutic approaches that target mitochondria in the context of neurodegenerative diseases. Since these treatments in neurological disorders have shown different degrees of progress, it is essential to perform a detailed assessment of the significance of mitochondrial deterioration in neurodegenerative diseases and of a pharmacological treatment at this stage.
Assortative mating and mate‐choice contributes to the maintenance of a developmental dimorphism in Streblospio benedicti
Authors: Ruskie Erika L. , Zakas Christina 
Published: May 2023

AbstractAssortative mating, where individuals non‐randomly mate with respect to phenotype or genotype, can occur when preferences between potential mates have evolved. When such mate preferences occur in a population it can drive evolutionary and phenotypic divergence. But the extent to which assortative mating, mate preference, and development are evolutionarily linked remains unclear. Here we use Streblospio benedicti, a marine annelid with a rare developmental dimorphism, to investigate if mate‐choice could contribute to developmental evolution. For S. benedicti two types of ecologically and phenotypically similar adults persist in natural populations, but they give rise to distinctly different offspring with alternative life‐histories. This dimorphism persists despite the absence of post‐zygotic reproductive barriers, where crosses between the developmental types can produce phenotypically intermediate offspring. How this life‐history strategy evolved remains unknown, but assortative mating is a typical first step in evolutionary divergence. Here we investigate if female mate‐choice is occurring in this species. We find that mate preferences could be contributing to the maintenance of alternative developmental and life‐history strategies.
Characteristics and Outcomes of Surgical Treatment for Bronchial Anomalies
Authors: Kao Derek D. , Fuu‐Kou Yann , Wang Cynthia S. , Lehenbauer David , Zak Sara , Benscoter Dan , Morales David LS , de Alarcon Alessandro , Rutter Michael J 
Published: May 2023

ObjectivesBronchial anomalies are rare but challenging conditions to treat in children, encompassing a variety of structural abnormalities that could compromise airway patency. This includes complete rings, absent cartilage, traumatic avulsions, bronchoesophageal fistulas, and cartilaginous sleeves. The objective of this study is to describe the characteristics and outcomes of a series of pediatric cases of bronchial anomalies that were treated by slide tracheobronchoplasty.MethodsThis is a single‐institution retrospective case series of pediatric patients with bronchial anomalies who underwent surgical treatment between February 2004 and April 2020. Data extracted from electronic medical records included patient demographics, comorbidities, and surgical outcomes.ResultsThere were a total of 29 patients included in the study, of which 14 had complete bronchial rings, 8 had absent bronchial rings, 4 had traumatic bronchial avulsions, 2 had bronchoesophageal fistulas, and one had a cartilaginous sleeve. Median follow‐up time was 13 months (with a range of 0.5–213 months). The overall mortality rate was 17.2% (5 patients), all of whom had complete bronchial rings. Patients with complete bronchial rings also had a higher rate of not only cardiac (85.7%) and pulmonary comorbidities (85.7%) but also secondary airway lesions (78.6%).ConclusionThis is the largest series to date describing surgical treatment for bronchial anomalies. Complete bronchial rings were the most common anomaly treated, followed by absent rings and trauma. Surgical treatment can be successful but mortality rates are higher in patients with complete bronchial rings, possibly due to higher rates of pulmonary and cardiac comorbidities.Level of Evidence4 Laryngoscope, 133:3334–3340, 2023
Unlocking the flow experience in apps: Fostering long‐term adoption for sustainable healthcare systems
Authors: Gómez‐Rico Mar , Santos‐Vijande María Leticia , Molina‐Collado Arturo , Bilgihan Anil 
Published: May 2023

AbstractMobile health apps are increasingly being recognized as effective tools for improving the efficiency and sustainability of healthcare systems. However, a major challenge faced by the industry is achieving long‐term adoption of Apps. This is a critical issue because many apps are abandoned after only a few uses, and low adoption rates limit the potential impact of these apps on healthcare outcomes. In this paper, we examine this issue by integrating the Customer Value Theory and the Person‐Artifact‐Task model to study how the functional experience of app users, derived from technology features such as perceived ease of use, personalization, and usefulness, enables a state of flow through the users’ hedonic and social experiences of recognition and attractiveness. We comprehensively measure the impact of the psychological state of flow in terms of users’ cognitive, emotional, and conative responses. Our results indicate that the functional experience of users is central to achieving flow through hedonic and social experiences, while other antecedents of flow, such as health severity and health empowerment, have a lower impact on app use. Developing a positive psychological response towards Apps is also essential to improve users’ perception of health improvement, satisfaction, and loyalty. By understanding the factors that contribute to long‐term adoption of apps, we can better design and promote these apps to improve healthcare outcomes and promote sustainable healthcare systems.
Quality differentiation and e‐tailer's choice between reselling and agency selling
Authors: Wang Le , He Zhen , He Shuguang 
Published: May 2023

AbstractMany manufacturers sell products through both the e‐retail and direct channels, which may lead to channel conflicts. To alleviate this, quality differentiation becomes an important marketing strategy for the manufacturer. However, few studies investigate how the form of the e‐tailer's selling contract affects the manufacturer's distribution strategy. Here, we investigate this by establishing a game model in which a manufacturer sells two products with similar functions, but different quality levels, through the direct channel and an e‐tailer. The manufacturer may distribute high‐ and low‐quality products through the direct and e‐tailer channels, respectively, or vice versa. The e‐tailer can choose either the reselling or agency selling contracts. We find that the impact of quality differentiation on equilibria depends on the distribution strategy, contract form, and level of product competition. Under the reselling contract, the manufacturer (he) should distribute high‐quality products directly if the relative efficiency of low‐ to high‐quality products is low. Under the agency selling contract, he should distribute low‐quality products directly if the relative efficiency is moderate. Finally, the e‐tailer (she) should choose the agency selling contract if the production cost is moderate, regardless of the manufacturer's distribution strategy.
The influence of child pain catastrophizing and parent behavior on health‐related quality of life in pediatric sickle cell disease
Authors: Shneider Caitlin E. , Cohen Lindsey L. , Shih Sharon W. , Sil Soumitri 
Published: May 2023

AbstractBackgroundLiterature suggests that a child's appraisal of pain and parent responses to pain are critical in predicting health‐related outcomes. In youth with sickle cell disease (SCD), few investigations have examined child pain catastrophizing, and even fewer have examined the role that parents play in responding to SCD pain within the family context. The purpose of the current study was to examine the relationship between pain catastrophizing, parent response to child SCD pain, and health‐related quality of life (HRQoL).ProcedureThe sample (N = 100) included youth with SCD (ages 8–18) and their parent. Parents completed a demographic questionnaire and the Adult Responses to Child Pain Symptoms; youth completed the Pain Catastrophizing Scale and Pediatric Quality of Life Inventory—SCD Module.ResultsFindings indicated that pain catastrophizing, parent minimization, and parent encouragement/monitoring significantly predicted HRQoL. Minimizing and encouragement/monitoring parent responses moderated the relationship between pain catastrophizing and HRQoL, such that parent minimizing weakened the relationship and parent encouragement/monitoring strengthened the relationship.ConclusionsParalleling pediatric chronic pain literature, findings suggest that pain catastrophizing predicts HRQoL in youth with SCD. However, findings from moderation analyses diverge from the chronic pain literature; data suggest that encouragement/monitoring responses strengthen the negative relationship between child pain catastrophizing and HRQoL. Child pain catastrophizing and parent response to SCD pain may be appropriate targets for clinical intervention to improve HRQoL. Future studies should strive to better understand parent responses to SCD pain.
Evaluation of the change in efficacy of erenumab when used long‐term for migraine prevention after initial established benefit in a veteran population
Authors: Martin Alison W. , Cubellis Mara 
Published: May 2023

AbstractIntroductionWith the increased use of erenumab and other calcitonin gene‐related peptide antagonists for migraine prevention, increased evidence on long‐term efficacy and real‐world effectiveness is needed. Some reports of a wearing‐off effect or waning efficacy over time have been observed with erenumab use.ObjectiveThis study evaluated the change in efficacy of erenumab after initial established benefits for migraine prevention in a veteran population.MethodsThis retrospective chart review evaluated patients who were prescribed erenumab for migraine prevention at a Veterans Affairs neurology clinic between June 1, 2018, and May 31, 2021. Patients with an initial 50% or greater reduction in mean monthly headache days (MHDs) by 12 weeks after erenumab 70 mg initiation were then followed forward to determine the change in MHDs until erenumab dose was increased, changed to galcanezumab, or by November 30, 2021, to ensure a minimum 6‐month follow‐up for all patients.ResultsNinety‐three patients were included for analysis. A significant reduction in mean MHDs from 16.1 to 5.7 days was found by 12 weeks after erenumab 70 mg initiation (p < 0.0001). Following this initial response to erenumab, 69% of patients experienced a significant increase in MHDs over an average time of 7.8 months and required a subsequent dose increase to erenumab 140 mg or change to galcanezumab. The remaining 31% of patients continued erenumab 70 mg monthly with a further nonstatistically significant decline in MHDs.ConclusionsA decrease in efficacy with the long‐term use of erenumab was observed for the majority of patients evaluated in this analysis. This suggests that patients with initial benefits on lower dose erenumab should be monitored for change to effectiveness.
A selectivity‐enhanced colloidal crystal array for ribavirin sensing based on the synergistic effect of covalent and non‐covalent interactions
Authors: Chen Wei , Sun Yi , Zhang Lirui , Fu Min , Wang Kunhua , Gao Meng 
Published: May 2023

AbstractRibavirin is an important antiviral with demonstrated activity against coronaviruses such as severe acute respiratory syndrome coronavirus and coronavirus disease 2019 virus. However, abuse of ribavirin will cause great environmental damage and threaten human health owing to its reproductive toxicity and teratogenicity. Therefore, an innovative detection method is demanded for simple and sensitive detection of ribavirin. This work reports an imprinted colloidal crystal array (ICCA) for ribavirin sensing. The building blocks of the ICCA are ribavirin imprinted spheres, which possess superior binding efficiency toward ribavirin. Benefiting from the highly ordered structure, the ICCA exhibits optical properties which change upon binding ribavirin. The changes in reflectance wavelength enable a fast and label‐free detection of ribavirin between 21 and 245 μmol L−1. Moreover, the sensor shows excellent selectivity for ribavirin detection in river water. Overall, all the results reported in this work demonstrate that the ICCA should be a promising detection tool for antivirals. © 2023 Society of Industrial Chemistry.
Condensation of the β‐cell secretory granule luminal cargoes pro/insulin and ICA512 RESP18 homology domain
Authors: Toledo Pamela L. , Vazquez Diego S. , Gianotti Alejo R. , Abate Milagros B. , Wegbrod Carolin , Torkko Juha M. , Solimena Michele , Ermácora Mario R. 
Published: May 2023

AbstractICA512/PTPRN is a receptor tyrosine‐like phosphatase implicated in the biogenesis and turnover of the insulin secretory granules (SGs) in pancreatic islet beta cells. Previously we found biophysical evidence that its luminal RESP18 homology domain (RESP18HD) forms a biomolecular condensate and interacts with insulin in vitro at close‐to‐neutral pH, that is, in conditions resembling those present in the early secretory pathway. Here we provide further evidence for the relevance of these findings by showing that at pH 6.8 RESP18HD interacts also with proinsulin—the physiological insulin precursor found in the early secretory pathway and the major luminal cargo of β‐cell nascent SGs. Our light scattering analyses indicate that RESP18HD and proinsulin, but also insulin, populate nanocondensates ranging in size from 15 to 300 nm and 10e2 to 10e6 molecules. Co‐condensation of RESP18HD with proinsulin/insulin transforms the initial nanocondensates into microcondensates (size >1 μm). The intrinsic tendency of proinsulin to self‐condensate implies that, in the ER, a chaperoning mechanism must arrest its spontaneous intermolecular condensation to allow for proper intramolecular folding. These data further suggest that proinsulin is an early driver of insulin SG biogenesis, in a process in which its co‐condensation with RESP18HD participates in their phase separation from other secretory proteins in transit through the same compartments but destined to other routes. Through the cytosolic tail of ICA512, proinsulin co‐condensation with RESP18HD may further orchestrate the recruitment of cytosolic factors involved in membrane budding and fission of transport vesicles and nascent SGs.
Consent for gynaecological imaging in Australian and New Zealand adolescent patients: A discussion of legal considerations in sonography
Authors: Humphries‐Hart Ffion , Bethune Michael , Donnan Alexander , Stone Kate , Lee Anna , Grover Sonia 
Published: May 2023

AbstractA gynaecological ultrasound on an adolescent patient can involve a transabdominal (TAUS), transvaginal (TVUS), trans‐perineal (TPUS) or transrectal (TRUS) approach. Following TAUS a TVUS or TRUS may be suitable on an adolescent patient if they are determined to be a ‘mature minor’/Gillick competent and provide informed consent. Legal information on adolescent consent to medical treatment is difficult for sonographers to obtain as current professional guidelines are not sufficiently detailed on the laws of consent to medical treatment and workplace policies are often not specific to adolescent patients. This manuscript provides information on informed consent to medical treatment, ‘mature minor’/Gillick competence determination, Australian and New Zealand legislation for ‘mature minors’ to consent to medical treatment, adolescent psychology and avoiding coercion when obtaining consent.
Characterization of Starch Nanocrystals from Lablab purpureus (L.) Sweet and Its Application as a Stabilizer in Pickering Emulsions
Authors: Iswalal Micael , Mellem John J. 
Published: May 2023

AbstractPickering emulsions is a concept developed to address the weaknesses of conventional colloidal systems. The stabilization of Pickering emulsions by starch nanocrystals (SNCs) is proposed due to their small size, in this study the physicochemical properties of SNCs extracted from Lablab purpureus (L.) sweet starch and its role as a pickering emulsifier are evaluated. SNCs are obtained using two conventional hydrolysis methods (acid hydrolysis [AH] and enzymatic hydrolysis [EH]) and characterized based on their structural, thermal, and crystallinity properties. The particle diameter of nanocrystals ranges from 92 to 135 nm with highly stable zeta‐potential values. FTIR analysis confirms that there are higher peak intensities observed for L. purpureus SNCs compared to native starch. Water and oil binding capacity results show that hydrophobic and hydrophilic capacities of native starch are altered significantly after EH and AH. For application and stability evaluation, emulsions are prepared by utilizing SNCs concentrations from 0.1 to 1.5% w/v. The 1.5% concentration of SNCs AH and EH shows the best physical, thermal, and storage stability compared to lower concentrations. Findings from this study show that this natural‐based nanocrystal has high potential for use as a stabilizer or emulsifier in colloidal systems.
Several Remarks on Norm Attainment in Tensor Product Spaces
Authors: Zoca Abraham Rueda 
Published: May 2023

AbstractThe aim of this note is to obtain results about when the norm of a projective tensor product is strongly subdifferentiable. We prove that if $$X\widehat{\otimes }_\pi Y$$

X

⊗
^

π

Y

is strongly subdifferentiable and either X or Y has the metric approximation property then every bounded operator from X to $$Y^*$$

Y
∗

is compact. We also prove that $$(\ell _p(I)\widehat{\otimes }_\pi \ell _q(J))^*$$

(

ℓ
p

(
I
)

⊗
^

π

ℓ
q

(
J
)

)

∗

has the $$w^*$$

w
∗

-Kadec-Klee property for every non-empty sets I, J and every $$2<p,q<\infty $$

2
<
p
,
q
<
∞

, obtaining in particular that the norm of the space $$\ell _p(I)\widehat{\otimes }_\pi \ell _q(J)$$

ℓ
p

(
I
)

⊗
^

π

ℓ
q

(
J
)

is strongly subdifferentiable. This extends several results of Dantas, Kim, Lee and Mazzitelli. We also find examples of spaces X and Y for which the set of norm-attaining tensors in $$X\widehat{\otimes }_\pi Y$$

X

⊗
^

π

Y

is dense but whose complement is dense too.
Associations between clinical and psychosocial factors and HbA1c in adult insulin pump users with type 1 diabetes
Authors: Schmidt Signe , Madsen Kristoffer Panduro , Pedersen-Bjergaard Ulrik , Rytter Karen , Hommel Eva , Cleal Bryan , Willaing Ingrid , Andersen Henrik Ullits , Nørgaard Kirsten 
Published: May 2023

Abstract
Aims
Many adults with type 1 diabetes do not achieve recommended glycemic goals despite intensive insulin therapy using insulin pumps. The aim of this study was to explore associations between clinical and psychosocial factors and HbA1c in insulin pump users to identify and prioritize areas for potential intervention.

Methods
A questionnaire-based survey covering clinical and psychosocial aspects of life with type 1 diabetes was distributed to all adult (≥ 18 years) insulin pump users in the Capital Region of Denmark. Responses were combined with data from medical records and national registries. Associations with HbA1c were modeled using regression-based machine learning.

Results
Of 1,591 invited individuals, 770 (48.4%) responded to the survey. Mean HbA1c among responders was 7.3% (56 mmol/mmol), and 35.6% had an HbA1c < 7.0% (53 mmol/mol). Six factors were significantly associated with HbA1c: diabetes duration (0.006% (0.1 mmol/mol) lower HbA1c per 1-year increase in diabetes duration); education (0.4% (4.3 mmol/mol) lower HbA1c with long higher education vs. primary school); insulin type (0.2% (2.2 mmol/mol) lower HbA1c with ultra-rapid-acting insulin vs. rapid-acting insulin); hypoglycemia awareness status (0.2% (2.2 mmol/mol) lower HbA1c with complete unawareness vs. full awareness); insulin device satisfaction (0.2% (2.7 mmol/mol) lower HbA1c per 1-point increase in Insulin Device Satisfaction Survey score); and diabetes distress (0.3% (3.1 mmol/mol) higher HbA1c per 1-point increase in Type 1 Diabetes Distress Scale score).

Conclusions
This study identified several associations between clinical and psychosocial factors and HbA1c that may be considered when developing interventions targeted people with type 1 diabetes.