bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dopamine Drives Feedforward Inhibition to Orexin Feeding System, Mediating Weight Loss Induced by Morphine Addiction
Authors: Li Huiming , Wang Sa , Wang Dan , Li Jiannan , Song Ge , Guo Yongxin , Yin Lu , Tong Tingting , Zhang Haopeng , Dong Hailong 
Published: January 2025

AbstractFeeding behavior changes induced by opioid addiction significantly contribute to the worsening opioid crisis. Activation of the reward system has shown to provoke binge eating disorder in individuals with opioid use disorder, whereas prolonged opioid exposure leads to weight loss. Understanding the mechanisms underlying these phenomena is essential for addressing this pressing societal issue. This study demonstrates that weight loss resulting from feeding behavior changes during morphine addiction requires the activation of the ventral tegmental area dopamine (DA) system, which suppresses the orexin feeding center. Specifically, DA exerts an inhibitory effect on orexin neurons in the lateral hypothalamus area (LHA) through a feedforward inhibition mediated by GABA neurons in the LHA, involving D1 receptors (D1R) and T‐type Ca2+ channels. Moreover, the morphine addiction‐induced reduction in body weight and food intake can be reversed by the D1R antagonist SCH23390 and chemogenetic silencing of GABA neurons in the LHA. These findings delineate a neuromodulatory mechanism underlying morphine addiction‐associated feeding behavior changes and weight loss.
Design Principles From Natural Olfaction for Electronic Noses
Authors: Patel Haritosh , Garrido Portilla Vicente , Shneidman Anna V. , Movilli Jacopo , Alvarenga Jack , Dupré Christophe , Aizenberg Michael , Murthy Venkatesh N. , Tropsha Alexander , Aizenberg Joanna 
Published: January 2025

AbstractNatural olfactory systems possess remarkable sensitivity and precision beyond what is currently achievable by engineered gas sensors. Unlike their artificial counterparts, noses are capable of distinguishing scents associated with mixtures of volatile molecules in complex, typically fluctuating environments and can adapt to changes. This perspective examines the multifaceted biological principles that provide olfactory systems their discriminatory prowess, and how these ideas can be ported to the design of electronic noses for substantial improvements in performance across metrics such as sensitivity and ability to speciate chemical mixtures. The topics examined herein include the fluid dynamics of odorants in natural channels; specificity and kinetics of odorant interactions with olfactory receptors and mucus linings; complex signal processing that spatiotemporally encodes physicochemical properties of odorants; active sampling techniques, like biological sniffing and nose repositioning; biological priming; and molecular chaperoning. Each of these components of natural olfactory systems are systmatically investigated, as to how they have been or can be applied to electronic noses. While not all artificial sensors can employ these strategies simultaneously, integrating a subset of bioinspired principles can address issues like sensitivity, drift, and poor selectivity, offering advancements in many sectors such as environmental monitoring, industrial safety, and disease diagnostics.
Secernin‐2 Stabilizes Histone Methyltransferase KMT2C to Suppress Progression and Confer Therapeutic Sensitivity to PARP Inhibition in Triple‐Negative Breast Cancer
Authors: Huang Min‐Ying , Cai Jia‐Yang , Yang Shao‐Ying , Zhao Qian , Shao Zhi‐Min , Zhang Fang‐Lin , Zhang Yin‐Ling , Cao A‐Yong , Li Da‐Qiang 
Published: January 2025

AbstractTriple‐negative breast cancer (TNBC) is a difficulty and bottleneck in the clinical treatment of breast cancer due to a lack of effective therapeutic targets. Herein, we first report that secernin 2 (SCRN2), an uncharacterized gene in human cancer, acts as a novel tumor suppressor in TNBC to inhibit cancer progression and enhance therapeutic sensitivity to poly(ADP‐ribose) polymerase (PARP) inhibition both in vitro and in vivo. SCRN2 is downregulated in TNBC through chaperone‐mediated autophagic degradation, and its downregulation is associated with poor patient prognosis. Moreover, SCRN2 impedes the proteasomal degradation of histone‐lysine N‐methyltransferase 2C (KMT2C) by recruiting Bcl2‐associated athanogene 2 to block the interaction of KMT2C with E3 ubiquitin‐protein ligase CHIP. Consistently, SCRN2 transcriptionally activates Bcl2‐modifying factor by amplifying histone H3 monomethylation at lysine 4 at its enhancer, thereby inducing intrinsic apoptosis. Notably, KMT2C knockdown restores the impaired TNBC progression caused by SCRN2 overexpression both in vitro and in vivo. Furthermore, SCRN2 decreases the expression of key DNA repair‐related genes and induces endogenous DNA damage, thus conferring therapeutic sensitivity of TNBC cells to PARP inhibition. Collectively, these findings identify SCRN2 as a novel suppressor of TNBC, reveal its mechanism of action, and highlight its potential role in TNBC therapy.
Ultrasensitive 129Xe Magnetic Resonance Imaging: From Clinical Monitoring to Molecular Sensing
Authors: Yang Yuqi , Yue Sen , Shen Luyang , Dong Huiling , Li Haidong , Zhao Xiuchao , Guo Qianni , Zhou Xin 
Published: January 2025

AbstractMagnetic resonance imaging (MRI) is a cornerstone technology in clinical diagnostics and in vivo research, offering unparalleled visualization capabilities. Despite significant advancements in the past century, traditional 1H MRI still faces sensitivity limitations that hinder its further development. To overcome this challenge, hyperpolarization methods have been introduced, disrupting the thermal equilibrium of nuclear spins and leading to an increased proportion of hyperpolarized spins, thereby enhancing sensitivity by hundreds to tens of thousands of times. Among these methods, hyperpolarized (HP) 129Xe MRI, also known as ultrasensitive 129Xe MRI, stands out for achieving the highest polarization enhancement and has recently received clinical approval. It effectively tackles the challenge of weak MRI signals from low proton density in the lungs. HP 129Xe MRI is valuable for assessing structural and functional changes in lung physiology during pulmonary disease progression, tracking cells, and detecting target molecules at pico‐molar concentrations. This review summarizes recent developments in HP 129Xe MRI, including its physical principles, manufacturing methods, in vivo characteristics, and diverse applications in biomedical, chemical, and material sciences. In addition, it carefully discusses potential technical improvements and future prospects for enhancing its utility in these fields, further establishing HP 129Xe MRI's importance in advancing medical imaging and research.
Injured Myocardium‐Targeted Theranostic Nanoplatform for Multi‐Dimensional Immune‐Inflammation Regulation in Acute Myocardial Infarction
Authors: Zheng Tao , Sheng Jie , Wang Zhiyue , Wu Haoguang , Zhang Linlin , Wang Sheng , Li Jianhua , Zhang Yunming , Lu Guangming , Zhang Longjiang 
Published: January 2025

AbstractPyroptosis is a key mode of programmed cell death during the early stages following acute myocardial infarction (AMI), driving immune‐inflammatory responses. Cardiac resident macrophages (CRMs) are the primary mediators of cardiac immunity, and they serve a dual role through their shaping of both myocardial injury and post‐AMI myocardial repair. To appropriately regulate AMI‐associated inflammation, HM4oRL is herein designed, an innovative bifunctional therapeutic nanoplatform capable of inhibiting cardiomyocyte pyroptosis while reprogramming inflammatory signaling. This HM4oRL platform is composed of a core of 4‐Octyl itaconate (4‐OI)‐loaded liposomes, a middle layer consisting of a metal‐polyphenol network (MPN) film, and an optimized outer hybrid immune‐cell membrane layer. The unique properties of this hybrid membrane layer facilitated HM4oRL targeting to the injured myocardium during early‐stage AMI in mice, whereupon the release of 4‐Ol and modified MPN synergistically inhibited cardiomyocyte pyroptosis while suppressing inflammatory monocytes/macrophage responses at the infarcted site. Mechanistically, HM4oRL preserved cardiac metabolic homeostasis through AMPK signaling activation, establishing favorable microenvironmental conditions for the reprogramming of CRM‐mediated inflammation. Ultimately, HM4oRL treatment is able to resolve inflammation, enhance neovascularization, and suppress myocardial fibrosis, reducing the infarct size and enhancing post‐AMI cardiac repair such that it is an innovative approach to the targeted treatment of AMI.
Reversible Ferroelectric Polarization Modulation of Chiral Molecular Ferroelectrics by Circularly Polarized Light
Authors: Wang Zhongxuan , Wang Qian , Quan Lina , Ren Shenqiang 
Published: January 2025

AbstractThe optical modulation of ferroelectric polarization constitutes a transformative, non‐contact strategy for the precise manipulation of ferroelectric properties, heralding advancements in optically stimulated ferroelectric devices. Despite its potential, progress in this domain is constrained by material limitations and the intricate nature of the underlying mechanisms. Recent studies have achieved efficient regulation of ferroelectric polarization and thermal conductivity in chiral ferroelectric thin films through the application of left‐ and right‐handed circularly polarized light (LCP and RCP). Differential absorption of circularly polarized light (CPL) induces nonequilibrium carrier dynamics, generating distinctive interfacial electrostatic fields that enable precise control of ultrathin ferroelectric films. For (R)‐BINOL−DIPASi and (S)‐BINOL−DIPASi (C26H26O2Si), polarization changes surpass 23%, exhibiting opposite response under LCP and RCP excitation. In R chiral films, remnant polarization decreases from 1.05 µC cm−2 under LCP to 0.85 µC cm−2 under RCP, whereas in S chiral films, polarization increases from 0.85 µC cm−2 under LCP to 0.98 µC cm−2 under RCP. This reversible modulation facilitates reliable switching between ON and OFF states, presenting the potential of chiral ferroelectric materials for flexible, high‐speed integrated photonic sensor technologies.
Prognostic factors for patients with esophageal cancer who achieve pathological complete response in the primary tumor after upfront chemotherapy or chemoradiotherapy
Authors: Motoori Masaaki , Tanaka Koji , Miyata Hiroshi , Yamasaki Makoto , Shiraishi Osamu , Takeno Atsushi , Makino Tomoki , Sugimura Keijiro , Yasuda Takushi , Doki Yuichiro 
Published: January 2025

AbstractAimUpfront chemotherapy (uCT) or upfront chemoradiotherapy (uCRT) followed by surgery is generally accepted as the standard treatment for patients with locally advanced esophageal cancer. A substantial proportion of patients achieve a pathological complete response (pCR) of the primary tumor with upfront treatment. This retrospective study aimed to clarify the prognostic factors of patients with esophageal cancer who achieve pCR in the primary tumor after upfront treatment and whether the prognosis of patients with pCR who receive uCT differs from that of patients who receive uCRT.MethodsThis study included 121 patients who achieved pCR of the primary tumor after uCT and 40 patients after uCRT. Univariate and multivariate survival analyses were performed.ResultsMultivariate analysis of overall survival demonstrated that gender, upfront treatment, and pathological lymph node metastasis were independent prognostic factors (p = 0.0086, 0.011, and 0.031, respectively). Multivariate analysis of relapse‐free survival demonstrated that gender, cM status, and pathological lymph node metastasis were independent prognostic factors (p = 0.033, 0.014, and 0.0010, respectively). Among patients without pathological lymph node metastasis, the uCT group showed significantly better both overall and relapse‐free survival than the uCRT group (p = 0.014 and 0.037, respectively). Recurrence occurred in 24 patients in the uCT group and 9 in the uCRT group. All of local treatment (chemoradiotherapy and surgery) for recurrent lesions was performed in the uCT group.ConclusionsMale genders and pathological lymph node metastasis are independent poor prognostic factors in patients with esophageal cancer who receive upfront treatment followed by surgery and achieved pCR of the primary tumor.
An Investigation Into the Influence of Titania–Carbon Nanotube Nanophotocatalysts Into the Filtration Performance of Polyethersulfone‐Based Membranes
Authors: Zikalala Sithembela A. , Mahlangu Oranso T. , Li Jianxin , Mamba Bhekie B. , Nxumalo Edward N. 
Published: January 2025

ABSTRACTThe polyethersulfone/sulfonated polyethersulfone (PES/SPSf) blend is enriched with ionizable sulfonic acid groups rendering a stable polymer system suited for blending nanocomposites using water as a dispersant. PES/SPSf/TiO2‐amorphous carbon nanotubes (aCNT) mixed matrix membranes are prepared via addition of a TiO2–aCNT/deionized water slurry and precipitated via non‐solvent induced phase separation. Membranes' electrostatic and non‐electrostatic interactions with charged organic pollutants and membrane–dye interactions are probed using the Liftshitz‐acid–base approach. Fluid transport and solute rejection mechanisms are investigated through porosity, pore radius, flux, permeance, dye rejection and fouling propensity. PES/SPSf/TiO2–aCNT membrane contact angle at 1.6 wt.% TiO2–aCNT loading reached 35° accompanied by pore radius decrease and a decline in membrane pure water permeability (197.7 for MF0 to 48.5 L.m−2.h−1 for MF1.6). Membranes had good rejection for cationic azure B (≈90%) and zwitterionic rhodamine B (≈100%) compared to anionic charged methyl orange (MO) (2.0%–10.8%). Major dye removal mechanism was size exclusion, where reactive red 120 (1335.9 g/mol) retention was higher than that of MO (327.4 g/mol). TiO2–aCNT loading imputes membranes additional cationic charge and electron donor components that enables solute transportation via electrostatic switching mechanism and charge‐dependent antifouling for reactive dyes, which are the bulk of textile industry pollution.
Small fish, large variation: Morphological diversity of Weberian apparatus in Noturus catfishes and ecological implications
Authors: Hoeflich J. C. , Liu Juan 
Published: January 2025

AbstractThe Weberian apparatus is a hearing specialization unique to the otophysan fishes, and an unexpected degree of morphological variation exists in species of the Noturus catfishes. Our aim in this study is to investigate relationships between morphological variations and ecology that may drive this variation. Sampling 48 specimens representing 25 species, we investigated morphological diversity and accounted for ecological variables using landmark‐based 3D geometric morphometrics and x‐ray‐based computed tomography (CT) images. We tested five ecological variables using three landmark sets in three focused regions: the tripus, scaphium, and overall shape of the peripheral structures including the complex vertebra. We performed phylogenetic signal tests, and phylogenetic influence is not significant within Noturus in any of the three regions. Among the tested ecological variables, stream velocity and coloration (a proxy for substrate) were found to be significantly associated with the morphology of the tripus and scaphium, the first and the last ossicles of the sound transmitting chain. This eco‐morphology connection may be mediated through stream velocity's dominant role in defining the soundscape of aquatic environments and substrate material properties contributing to which sounds are produced and propagated. We conclude that Noturus catfishes could be acoustically adapted to their microhabitats.
Dynamic Capabilities as Enablers for Sustainability‐Oriented Innovation: A Case Study in a Footwear Industry
Authors: Gohr Cláudia Fabiana , Rodrigues Bruna Cavalcanti Barros 
Published: January 2025

ABSTRACTThe literature indicates the relevance of sustainability‐oriented innovation (SOI). However, the knowledge about the influence of dynamic capabilities (DCs) and critical factors (CFs) in developing these innovations is still insufficient. This paper aims to analyze the DCs' influence (through CFs) in developing SOIs through an in‐depth explorative case study in two Brazilian unities at a multinational shoe company. The empirical results showed that the development of SOIs depends on the high influence on environmental, resource integration, and technological capabilities and moderate influence on absorptive, organizational, and networking capabilities due to the absence or nonstructuring of its CFs. “Waste management” (related to environmental DC) and “reputation (related to organizational DC)” emerged from empirical evidence. The paper provides empirical evidence of DC's influence (through CFs) in developing SOIs by suggesting eight propositions.
The Social Innovation of Academic Spin‐Offs From a Multilevel Approach
Authors: Camelo‐Ordaz Carmen , Diánez‐González Juan Pablo , Franco‐Leal Noelia , Sousa‐Ginel Elena 
Published: January 2025

ABSTRACTThe academic entrepreneurship literature has yet to consider the factors that affect social innovation in academic spin‐offs. Given this gap, this study adopted a knowledge‐based perspective and considers the antecedents of social innovation at two levels of analysis: academic spin‐offs and parent universities. Specifically, we analyzed the influence of academic spin‐offs' technological competence, entrepreneurial team functional heterogeneity, and funding type; and the moderating role of the parent university's social responsibility. A multilevel analysis was applied to a sample of 165 academic spin‐offs. The results revealed that technological competence, entrepreneurial team functional heterogeneity, and public funding sources positively influenced social innovation. However, venture capital funding negatively affected innovation. The results also showed that the parent university's social responsibility moderated the effect of functional heterogeneity but not the influence of technological competence. These findings contribute to the integration of the academic entrepreneurship literature within the field of social innovation.
Changes in Circadian Rhythm in Chronically‐Starved Mice Are Associated With Glial Cell Density Reduction in the Suprachiasmatic Nucleus
Authors: Zimmermann Annelie , Priebe Julia , Rupprecht Hanna , Lang Stephan , Haberland Fabienne , Schuster Katharina , Staffeld Anna , Berger Christoph , Zhu Hang , Dück Alexander , Kölch Michael , Frintrop Linda 
Published: January 2025

ABSTRACTObjectiveAnorexia nervosa (AN) is an eating disorder characterized by severe weight loss and associated with hyperactivity and circadian rhythm disruption. However, the cellular basis of circadian rhythm disruption is poorly understood. Glial cells in the suprachiasmatic nucleus (SCN), the principal circadian pacemaker, are involved in regulating circadian rhythms. We hypothesize that the circadian rhythm disruption in AN patients is associated with glial cell changes in the SCN.MethodIn the starvation‐induced hyperactivity mouse model, mice had free access to a running wheel and received a restricted amount of food once a day, until a 25% body weight loss was reached and maintained their weight loss for two weeks. This was followed by a refeeding phase. Different daily periods of running wheel activity were defined, such as food anticipatory activity up to 4 h before feeding. Circadian rhythmicity was analyzed using the cosinor method. Gene expression was evaluated using real‐time polymerase chain reaction. Immunohistochemistry was used to quantify astrocytes, microglia, and oligodendrocytes.ResultsStarvation induced changes in circadian rhythm, as indicated by changes in cosinor‐based characteristics. Refeeding reversed these effects. Additionally, there was an increase in cryptochrome circadian regulator 1 expression and a decrease in the density of astrocytes and oligodendrocytes in the SCN after chronic starvation.DiscussionStarvation‐induced alterations in circadian rhythms are associated with molecular, and cellular changes in the hypothalamus. Reduced astrocytes and oligodendrocytes in the SCN in a mouse model of AN suggest that glial pathophysiology may play a role in circadian rhythm disruption.
The Impact of Astroglia Kir4.1 Channel Dysfunction on Neuronal Activity and Autism‐Related Behavioral Abnormalities
Authors: Davoudi Shima , Rahdar Mona , Borjkhani Mehdi , Alavi‐Majd Hamid , Hosseinmardi Narges , Behzadi Gila , Janahmadi Mahyar 
Published: January 2025

ABSTRACTAutism spectrum disorder (ASD) is marked by neurobehavioral developmental deficits, potentially linked to disrupted neuron–glia interactions. The astroglia Kir4.1 channel plays a vital role in regulating potassium levels during neuronal activation, and mutations in this channel have been associated with ASD. This study investigates astroglia Kir4.1 as a regulator of neuronal excitability and behavioral abnormalities in rats with autistic‐like traits induced by prenatal exposure to valproic acid (VPA). Whole‐cell patch‐clamp recordings were obtained from pyramidal neurons in the hippocampal CA1 region, showing that inhibition of Kir4.1 channels led to electrophysiological changes indicative of neuronal hyperexcitability, similar to that seen in VPA‐exposed neurons. Specifically, there was increased input resistance and voltage threshold, alongside decreased time constant and rheobase. Behavioral assessments after 7 days of intrahippocampal PA6 (5 μg/mL/day) administration revealed significant social withdrawal, heightened anxiety, reduced exploration, and impaired recognition memory, underscoring the behavioral deficits linked to autism. While Kir4.1 inhibition affected excitability, it did not alter the output of CA1 pyramidal neurons in autistic‐like rats. These findings emphasize the critical role of astroglia Kir4.1 channels in modulating neuronal excitability and associated behavioral impairments within the VPA‐induced autism model, suggesting a promising target for future therapeutic interventions.