bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of The Value of COVID-19 Vaccine in General Public in South- east of Iran: A Willingness to pay Study
Authors: Najafi Saman , Goudarzi Reza , Feyzabadi Vahid Yazdi 
Published: September 2023

Abstract
Background:
The COVID-19 virus is a recent global phenomenon that emerged in 2019, and its impact has affected the lives of billions of people in various ways. Since the government provides vaccination for free, it is necessary to perform an economic valuation through willingness-to-pay analysis to determine its value in monetary terms. This study aims to estimate the amount that the general public of Kerman city is willing to pay for COVID-19 vaccine.
Methods:
This is a cross-sectional survey study conducted in September 2022 using face-to-face interviews with the general public of Kerman city, located in the southeastern region of Iran. Cochran's formula was used to determine the sample size of 500 households, selected through the Multistage sampling method. An open-ended question approach was employed to estimate the willingness of individuals to pay for the COVID-19 vaccine. The main questionnaire of the study consisted of three parts. Quantification tests were conducted to check for normality and variance heterogeneity, and the Kolmogorov-Smirnov test was used to verify the normality of the data. Stata 17 software was used for data analysis.
Results:
The open-ended question results of the respondents' willingness to pay for the COVID-19 vaccine showed that the highest average stated was for the AstraZeneca vaccine ($9.73), while the lowest average reported was for the domestically produced vaccine ($5.74). Factors affecting the willingness to pay were examined, and it was found that variables such as employment status, education level, attitude towards vaccination, income, and number of vaccine doses significantly influenced the willingness to pay.
Conclusion:
Based on the findings of this study, as low-income individuals and those with lower levels of education reported a lower willingness to pay, it is recommended that the government provide free vaccination to low-income groups and focus on building trust and promoting vaccine culture among those with lower education levels. Additionally, measures can be taken to enable high-income individuals to obtain the vaccine through the private sector.
Thermodynamic State Shift Observed Prior to the 2011 Mw 9 East Japan Earthquake through Data Mining Using Cellular Automaton
Authors: Kikuchi Hiroyuki 
Published: September 2023

Abstract
In this study, we employed our previously developed data mining method to show that a thermodynamic state shift occurred preceding the 2011 Mw 9 East Japan Earthquake (GEJE), coinciding with the onset of crustal stress manifestations. Our discussion starts with the insights obtained from our prior research, which revealed that small ground vibration fluctuations (GVF) detected near the epicenter of the GEJE are thermodynamically equivalent to a cellular automaton (CA). This equivalence allowed us to consider the "Process to GEJE," defined as the transition from GVF to catastrophic rupture in the GEJE, as analogous to the nonequilibrium-to-equilibrium thermodynamic transition in the CA. Therefore, if we find a thermodynamic state shift in the CA, it is reasonable to assume that a similar thermodynamic state shift may exist in the "Process to GEJE." We successfully derived a thermodynamic state function that exhibits a significant change before the nonequilibrium-to-equilibrium thermodynamic transition in the CA. By evaluating this thermodynamic state function using the GVF data of the "Process to GEJE," we discovered its maximum value occurring 1231 days before the GEJE. This maximum value can be considered as an indication of a thermodynamic state shift prior to the GEJE. It has been found that during this thermodynamic state shift prior to the GEJE, the GVF state approaches thermodynamic equilibrium, and an increase in crustal stress becomes visible for the first time.
Centrifugation effect on olive mill wastewater treatment by coagulation-flocculation using Ca(OH)2-pectin system
Authors: Moussaoui Ramdane , Lateb Yacine , Elias Abdelhamid , Sharrock Patrick , Amrouche Tahar 
Published: September 2023

Abstract

The aim of this research was the study of the centrifugation effect on olive mill wastewater (OMW) treatment by coagulation-flocculation using the Ca(OH)2-pectin system. To separate the treated OMW from the residual sludge, two methods were used: gravity decantation and centrifugation. Efficiency of the treatment was evaluated following the evolution of the OMW treated volumes and the reduction rates of dry matter (DM) and phenolic compounds (PC) and other parameters related to residual toxicity. Compared to gravity decantation, centrifugal separation significantly enhances the treatment of the OMW studied. Additionally, this separation method reduces considerably the treatment duration compared to gravity decantation i.e. 10 minutes instead of 4 hours. The lime-pectin system improved OMW purification. Optimal doses of lime and pectin were respectively 10 g/l and 0.2 g/l. Under these conditions, centrifugal separation allowed to obtain a volume of treated OMW about 78.2% of the raw effluent volume and reduced the rates of DM by 38% and of PC by 79%. The COD was also reduced by 60.0%. These results show that the resulting sludge may be used for production of fertilizers or land augmentation, thus avoiding costly disposal.
Multifractal Scaling characteristics of lineament networks of a fractured sandstone aquifer system
Authors: Abdi Safia , Chettih Mohamed 
Published: September 2023

Abstract

In this work, we have shown that we can carry out a multifractal characterization of fracturing from a network of lineaments, using a calculation code that we have developed ourselves and that we have named: 2D Calculation Code for Multifractal Analysis of Fracture Networks (2D-MAFN). Four lineament maps at different scales were analyzed, corresponding to the Upper Jurassic and Cretaceous geological formations of the El Gada region in the Central Algerian Saharan Atlas.The geometric analysis of the lineament networks showed good consistency between the lineament networks and the geological structure of the Atlas Range and its fault network. It also showed that the distribution of the lengths of the lineaments fits the power law. This analysis also revealed that, on a larger scale, diffuse fracturing appears to be more prevalent. In addition, the spectral analysis, through the decrease in spectral power according to a power law, characterizes a self-similar behavior and already seems to prove the scale invariance of the lineaments.The fractal dimension values obtained reflect the extent of fracturing and the degree of complexity of the network of lineaments. These values show that the lineaments are also well correlated with each other. The partition functions show that the points line up on the adjustment lines according to a law characteristic of multifractal behavior. In addition, the curves of generalized dimensions as a function of moments show a clear decrease, highlighting the multifractal nature of the fracturing process. In addition, the multifractal spectra in the form of bell curves also confirm the multifractal process for the four lineament networks analyzed.The results obtained are very encouraging and open up the prospects of modelling fracture networks for a variety of purposes, including assessing the connectivity of a fracture network.
Unique algorithm for the evaluation of embryo photon emission and viability
Authors: Berke József , Gulyás Istvan , Bognár Zoltán , Berke Dávid , Enyedi Attila , Kozma-Bognár Veronika , Mauchart Péter , Nagy Bernadett , Várnagy Ákos Várnagy , Kovács Kálmán , Bódis József 
Published: September 2023

Abstract
Living cells have spontaneous ultraweak photon emission derived from metabolic reactions associated with physiological conditions. The ORCA-Quest CMOS camera (Hamamatsu Photonics, Japan) is a highly sensitive and essential tool for photon detection; its use with a microscope incubator (Olympus) enables the detection of photons emitted by embryos with the exclusion of harmful visible light. With the application of the second law of thermodynamics, the low-entropy energy absorbed and used by embryos can be distinguished from the higher-entropy energy released and detectable in their environment. To evaluate higher-entropy energy data from embryos, we developed a unique algorithm for the calculation of the entropy-weighted spectral fractal dimension, which demonstrates the self-similar structure of the energy (photons) released by embryos. Analyses based on this structure enabled the distinction of living and degenerated mouse embryos, and of frozen and fresh embryos and the background. This novel detection of ultra-weak photon emission from mouse embryos can provide the basis for the development of a photon emission embryo control system. The ultraweak photon emission fingerprints of embryos may be used for the selection of viable specimens in an ideal dark environment.
Academic Burnout and Perfectionism in UK-based Physiotherapy Students
Authors: Biggs Daniel , Mckay Jane , Shanmugam Sivaramkumar 
Published: September 2023

Abstract

With perfectionism on the rise in education, students may be at greater risk to academic burnout than ever before. The aims of the study were to examine the academic burnout-perfectionism relationships, the prevalence rate, and mean scores of these variables in UK (United Kingdom) attending university physiotherapy students. 232 physiotherapy students (181 females, M age = 25.93 ± 7.15 years) completed academic burnout and multidimensional perfectionism measures. Bivariate correlations revealed a significant positive academic burnout-SPP relationship. Linear regression showed SPP to explain 12.4% of the variance of academic burnout. Additionally, 50% of the student sample exhibited moderate or high levels of academic burnout. Mean scores of SOP were high (5.14 ±1) and SPP scores were moderate to high (4.13±.88). This study’s findings provideinitial evidence of a relationship between academic burnout and SPP in physiotherapy students and add to the growing body of evidence showing SPP as a stronger direct predictor of academic burnout, relativeto SOP. Academic staff may employ a teaching strategy that is supportive to facilitating and emphasising learning with the outcome of self-fulfilment within modules compared to the promotion of a strategy that may render the individual concerned about meeting external standards is supportive to a holistic learning approach from the self, compared to the promotion of a strategy that may render the individual concerned about meeting external standards.
Effects and mechanisms of Zhizi Chuanxiong herb pair against atherosclerosis: An integration of network pharmacology, molecular docking and experimental validation
Authors: Zhang Yan , Qi Yifei , Jia Zijun , Li Yiming , Wu Liqi , Zhou Qing-bing , Xu Fengqin 
Published: September 2023

Abstract
Backgrounds

Zhizi Chuanxiong herb pair (ZCHP) can delay the pathological progression of atherosclerosis (AS). However, the exact pharmacological mechanism by ZCHP improves AS remain unclear due to the complexity of its components. Therefore, this study systematically elaborated the anti-AS mechanism of ZCHP.
Methods
The potential targets of ZCHP blood components were predicted by searching TCMSP, ETCM, BATMAN-TCM, STITCH and SwissTargetPrediction databases. Then, GEO database was used to search for disease targets associated with AS. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway analysis were performed by DAVID. Molecular docking was used to verify the binding of the core target with the blood components, and finally animal experiment was used to verify the mechanism of action.

Results

A ZCHP-components-targets-AS network was constructed using Cytoscape software, which included 16 main components and 58 candidate targets. Crucial genes, such as TNF, IL-1β, IGF1, MMP9, CCR5, HMOX1, PTGS1, SELE, ALOX5, and SYK were shown in PPI network. KEGG enrichment showed that TNF and NF-κB signaling pathway were put in an important position of the treatment. These results were validated by molecular docking method. In vivo, ZCHP significantly reduced pulse wave velocity, intima-media thickness, plaque area, and serum lipid levels, and increased difference between end-diastolic and end-systolic diameters in ApoE-/- mice. Meanwhile, ZCHP significantly decreased the mRNA and protein expression of TNF-α and IL-1β, suppressed NF-κB activation, and inhibited the M1 macrophage polarization marker CD86 in ApoE-/- mice.
Conclusion
This study combined network pharmacology, molecular biology and animal experiment to suggest that ZCHP could alleviate AS by suppressing TNF/NF-κB axis mediated M1 macrophage polarization.
The application of objective structured clinical examinations (OSCEs) for evaluating clinical internship in internal medicine
Authors: Yang Miao , Liu Yao , Dong Yuhan , Ding Yang , Lu Zhibing , Yu Mingxia , He Xingxing 
Published: September 2023

Abstract

Background
Clinical internship plays a vital role in enhancing medical students' theoretical knowledge, clinical operational abilities, and clinical thinking development. This study aims to establish an efficient evaluation system to assess interns' proficiency of clinical skills, and analyze the teaching effectiveness of clinical internships.
Methods
A total of 75 candidates from a 5 + 3 integrated medical training program, who had already completed a three-month clinical internship in internal medicine, participated in an Objective Structured Clinical Examination (OSCE). Four stations during the OSCE included history taking, abdominal physical examination, thoracentesis, and interpretation of auxiliary examination results. Both candidates and examiners voluntarily completed anonymous questionnaires immediately after the OSCE. Results were analyzed using the Chi-square test and the t-test as appropriate.
Results
In history taking station, new examiners awarded significantly higher scores compared to examiners with experience in conducting examinations (t = 1.711, P < 0.05). "5 + 3" candidates scored significantly higher than eight-year candidates in physical examination and thoracentesis station (t = 5.316 and t = 2.145, respectively; both p < 0.05). According to the questionnaire survey, the majority of candidates and all examiners were quite satisfied with its design, organization, quality and effectiveness. More than half of the candidates and examiners believed that insufficient practice and inadequate preparation for revision were the factors most likely to affect performance. 75% of the examiners felt that candidates needed the most training in operative steps and content, but only 56% and 40% of the candidates agreed with this view. Furthermore, 56% of candidates and half of the examiners identified operational methods and humanistic care as areas that still required intensive improvement.
Conclusions
This examination is an effective attempt to construct an OSCE evaluation system for the skills of medical students in the internship stage. This system can objectively and comprehensively reflect the students' clinical skills, promote the realization of evaluation feedback and quality management of clinical internship teaching, which can be promoted in the evaluation of clinical internship.
Diabetic Health Literacy and Associated Factors among Diabetic Patients Attending Outpatient Department at Public Hospitals in North Shoa Zone, Amhara Region, Ethiopia, 2022
Authors: Nigussie Elda Mekonnen , Asefa Eyosiyas Yeshialem , Demeke Mekasha Getnet , Adane Tigist Demssew , Mengistu Bethelehem Taye , Dessie Yihenew Ayehu , Mezgebu Getachew Sale , Worku Birhan Getye 
Published: September 2023

Abstract
Background
Diabetic health literacy plays an important role in determining diabetic outcomes. Despite the numerous health education programs, the outcome of the diabetic management remains a challenge globally & studies on diabetic health literacy are still lacking in Ethiopia. Therefore, the present study was aimed to assess the magnitude of diabetic health literacy and related factors among patients with diabetes attends outpatient department at public hospitals in North Shoa Zone, Amhara Region, Ethiopia, 2022
Methods
Institution based cross-sectional study design was conducted from May24-June24, 2022 at four randomly selected hospitals among 623 total study participants. The data was collected by face to face interview and reviewing the patient chart. The participants were selected by systematic random sampling. Data was entered in to Epi data version 4.6 and was exported to Stata version 14.1 for analyses. Ordinal logistic regression was conducted and a significant level was used at a p value of < 0.05.
Result
The present study included a total of 611 participants, with 98.1% response rate. Of all participants, 300(49.1%) had low, 174(28.5%) moderate &137(22.4%) had high diabetic health literacy level. The following factors; age; <40 years old (AOR = 3.48; 95%CI = 2.11, 5.77) & age 40–60 years (AOR = 2.79;95% CI = 1.75,4.46), Educational status (AOR = 0.29; 95% CI = 0.16,0.56) for who can’t read & write, (AOR = 0.41; 95% CI = 0.23,0.74) read & write & (AOR = 0.45;95% CI = 0.27,0.76) for primary school. exposure to diabetic education (AOR = 1.84; 95% CI = 1.31,2.58) having ≥ 2 sources of information (AOR = 2.28;95% CI = 1.57,3.32) moderate social support (AOR = 1.94;95%CI = 1.32,2.87), strong social support (AOR = 2.73;95% CI = 1.75,4.26),& Residence; lives in urban (AOR = 1.65; 95% CI = 1.14,2.39) were significant.
Conclusion
Compared to previous research carried out in Ethiopia, the overall diabetic health literacy level was low. Factors associated with diabetic Health Literacy were age, educational status, sources of information, attending diabetic education, social support and residence. Understanding of these factors might be the way for assisting patients and targeting specific intervention to develop patient’s diabetic health literacy.
Sensory Processing Subtypes in a Mixed Neurodevelopmental Cohort: Prevalence and Associations with Emotion Dysregulation, Anxiety, and ADHD
Authors: Brandes-Aitken Annie , Powers Rachel , Wren-Jarvis Jamie , Chu Robyn , Shapiro Kevin , Steele Mary , Mukherjee Pratik , Marco Elysa 
Published: September 2023

Abstract

Children with autism and other neurodevelopmental concerns (NDC) present an array of sensory processing patterns and frequently encounter challenges with self-regulation, including emotion dysregulation, anxiety, and ADHD symptoms. Adopting a transdiagnostic perspective within the Research Domain Criteria (RDoC) framework, this study examined the relationship between clusters of sensory processing phenotypes and differential patterns of self-regulation behaviors. In a sample of 117 participants (8–12 years), this study aimed to: 1) establish the prevalence of self-regulation problems in a community-recruited cohort of children with diverse NDCs; 2) construct data-driven sensory processing latent subtypes; 3) investigate group differences in emotion dysregulation, anxiety, and ADHD symptoms. Results indicated that 40, 20, and 62% of NDC children met clinically concerning thresholds for emotion dysregulation, anxiety, and ADHD, respectively. Second, latent profile analysis identified five sensory processing subtypes categorized by modality: Typical Processing, Intermediate/Mixed, Sensory Seeking (SS), Sensory Under-responsive (SUR), and Sensory Over-Responsive (SOR). Notably, the SOR group exhibited distinctively elevated anxiety scores, while the SS and SUR groups showed heightened ADHD scores. Intriguingly, the SOR, SUR, SS, and Intermediate/Mixed subgroups all demonstrated elevated emotion dysregulation scores, suggesting a potential shared mechanism of emotion dysregulation that might elucidate the connection between sensory processing differences and increased anxiety and ADHD behaviors in children with autism and other NDCs.
Tumor necrosis factor-a receptor 1 mediates changes in mitochondrial and peroxisomal dynamics in neurons – a mechanism contributing to Borna disease virus 1 persistence in the brain
Authors: Osei Dominic , Baumgart-Vogt Eveline , Ahlemeyer Barbara , Herden Christiane 
Published: September 2023

Abstract

Borna disease virus 1 (BoDV-1) causes a persistent, non-cytolytic infection in the mammalian brain accompanied by glial activation and T-cell-mediated neuroinflammation in susceptible end hosts. Peroxisomes and mitochondria play essential roles in cellular antiviral immune response, but the effect of BoDV-1 infection on peroxisomal and mitochondrial dynamics and their respective antioxidant capacities is still not clear. Using different mouse lines – i.e. tumor necrosis factor-α transgenic (TNFTg; to mimic chronic inflammation), TNF receptor-1 knockout (TNFR1ko), and TNFR2ko mice in comparison to wild-type (Wt) mice – we analyzed the abundances of both organelles and their main antioxidant enzymes, catalase and superoxide dismutase 2 (SOD2), in neurons of the hippocampus, cerebral and cerebellar cortices. In non-infected TNFTg mice, we detected a strong increase in mitochondrial (6.9-fold) and SOD2 (12.1-fold) abundances; peroxisomal abundance increased slightly (1.5-fold), but that of catalase decreased (2.9-fold). Unlike in TNFR1ko where no changes occurred, the abundances of both organelles, but not of their antioxidant enzymes, increased in TNFR2Ko mice. After BoDV-1 infection, a strong decrease in mitochondrial (2.1-6.5-fold), SOD2 (2.7-9.1-fold), and catalase (2.7-10.3-fold) abundances, but a slight increase in peroxisomes (1.3-1.6-fold) were detected in Wt and TNFR2ko mice, whereas no changes occurred in TNFR1ko mice. Chronic TNF overexpression prevented changes in peroxisome and catalase abundances, but not that of mitochondria and SOD2. Our data suggest that the TNF system is involved in the biogenesis of both subcellular organelles. Moreover, TNFR1 signaling mediated the BoDV-1-induced alterations of both organelles and the availability of their main antioxidant enzymes, highlighting new mechanisms by which BoDV-1 could achieve immune evasion and viral persistence.
The Effect of ellagic acid on physiological traits of plants grown from normal and aged soybean seeds
Authors: Arab Safiye , firouzabadi mehdi Baradaran baradaran , Gholami Ahmad , haydari mostafa 
Published: September 2023

Abstract
In order to decrease the effects of aging on seeds, antioxidants and phenolic compounds might be utilized. Included in this list of chemicals is ellagic acid. An experimental strategy was used in 2019 and 2020 to ascertain how ellagic acid affected the quality of soybeans. A factorial experiment was carried out in a randomized complete block design (RCBD) with three replications. Treatments included two initial seed quality (un-aged and aged seeds) and ellagic acid at four levels (control (zero), seed priming, foliar spray and seed priming + foliar spray at a concentration of 50 mg/L). Protein percentage, oil percentage and seed production in plants were all decreased by seed aging. Plants grown from seeds that had been treated with ellagic acid showed a 39.2 percent increase in seed yield. Seed yield increased by 45.3 percent after ellagic acid was sprayed on the leaves, also priming + foliar spray of ellagic acid increased protein yield by 60.6%. In conclusion, according to this study results, it may be suggested that using ellagic acid as a priming and foliar spray can reduce the negative effects of aged seeds.