bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of levetiracetam and valproate on late-onset post-traumatic seizures
Authors: Wang Yanli , Wang Yiqi , Wang Huifang , Du Xiaoping , Miao Jie , Tao James X. , Sun Meizhen 
Published: April 2023

Abstract
Background
To compare the preventive effects of levetiracetam and valproate on late-onset post-traumatic seizures in patients with traumatic brain injury (TBI).

Methods
A total of 95 patients with TBI were recruited from 2017 to 2020. They were randomized into three groups: levetiracetam (LEV) group (n = 30) receiving LEV treatment (500 mg, bid, po); valproate group (n = 32) receiving sodium valproate (500 mg/d, once daily, po); and control group (n = 33) receiving no anti-seizure medication. LEV and valproate were given to corresponding groups within seven days after TBI, and the administration lasted for one month. The incidence of epilepsy and adverse events were evaluated at 7 days and 12 months post-TBI.

Results
The cumulative incidences of late post-traumatic seizures at the 12-month follow-up in the LEV, valproate, and control groups were 3.33%, 12.50% and 15.63%, respectively. The cumulative incidence of late post-traumatic seizures in the LEV group was significantly lower than those in the valproate and control groups (P < 0.05). The cumulative incidence of late post-traumatic seizure in the valproate group was not significantly different from that in the control group (P > 0.05).

Conclusions
LEV can reduce the cumulative incidence of late post-traumatic seizures, whereas valproate can not.
Ultra-high birefringence with tuneable double zero chromatic dispersion-PCF: a theoretical analysis
Authors: Akowuah Emmanuel Kofi , Agbemabiese Patrick Atsu , Amoah Alexander Kwasi 
Published: April 2023

AbstractThis work presents photonic crystal fibres made up of four hexagonal shape of four rings. Four structures have been designed and configured. The structures show improvement in optical properties consecutively to achieve the optimum configuration. The full vectorial finite-element method is adopted for this work. COMSOL Multiphysics is used for the simulation. The results show a birefringence of 1.308 × 10−2 at 1.55 µm and tuneable double zero dispersion at wavelengths of 0.99 µm and 1.8 µm for x-polarisation mode. Also, the chromatic dispersion of − 24.062 ps/km nm and nonlinear coefficient of 30.32 W−1 km−1 are obtained at a telecommunication wavelength of 1.55 µm. The proposed photonic crystal fibre can be beneficial in nonlinear and supercontinuum applications since photonic crystal fibres of double zero dispersion demonstrate higher power spectral densities than single zero dispersion.
Seismic physical modeling study for a shale oil reservoir with complex lithofacies and meter-scale structures
Authors: Ding Pinbo , Zhang Feng , Chai Yibo , Luo Pingping , Gao Liangliang 
Published: April 2023

Shale oil reservoirs usually have various lithofacies with complex spatial patterns. Seismic reflections usually reveal the combination of sets of thin mud shales with various lithofacies. The seismic response characteristics of the lithofacies and the differences in seismic response of different lithofacies are still unclear, making the reservoir description difficult. The complex tectonic structures, diverse lithofacies, thin interlayers, fractures with various length scales, and various fracture development zones in the shale oil reservoir have placed very high demands on the design and construction method during the physical modeling of the shale oil reservoir. Facing these challenges, a physical modeling study on shale oil reservoirs with complex lithofacies and meter-scale structures is conducted. The target is the shale oil reservoir of the [Formula: see text] subsegment in the Jiyang depression. The complex physical model of a shale oil reservoir, with the thin stratigraphic layers and the complicated lithofacies and fracture patterns to date, has been designed and constructed in a laboratory. In total, 25 combinations of materials have been developed to simulate various lithofacies with different elastic parameters, and the error of the wave velocity simulation is less than 2.35%. The simulation of 1 m thick interlayers and the construction method for seismic physical models with meter-scale geologic structures has been realized. The quality control analysis finds that the simulation accuracy of small-scale geologic structure, complex lithofacies, and fractures is relatively reliable. Based on the physical model of the shale oil reservoir, high-density and wide-azimuth seismic data are acquired. Preliminary data processing and analysis find that the model layers have clear reflection characteristics, providing reliable data for the next step of seismic characteristics analysis of complex lithofacies shale oil reservoirs. The methodology has improved the capacity of seismic physical modeling to simulate complex oil and gas reservoirs, enabling the seismic physical simulation method to be applied in analyzing the commonly observed complex lithofacies, fractures, and meter-scale structures in unconventional oil and gas reservoirs.
Survival of Patients With Neuroblastoma After Assignment to Reduced Therapy Because of the 12- to 18-Month Change in Age Cutoff in Children's Oncology Group Risk Stratification
Authors: Bender Hannah G. , Irwin Meredith S. , Hogarty Michael D. , Castleberry Robert , Maris John M. , Kao Pei-Chi , Zhang Fan F. , Naranjo Arlene , Cohn Susan L. , London Wendy B. 
Published: April 2023

PURPOSE In 2006, Children's Oncology Group (COG) reclassified subgroups of toddlers diagnosed with neuroblastoma from high-risk to intermediate-risk, when the age cutoff for high-risk assignment was raised from 365 days (12 months) to 547 days (18 months). The primary aim of this retrospective study was to determine if excellent outcome was maintained after assigned reduction of therapy. PATIENTS AND METHODS Children <3 years old at diagnosis, enrolled on a COG biology study from 1990 to 2018, were eligible (n = 9,189). Assigned therapy was reduced for two cohorts of interest on the basis of the age cutoff change: 365-546 days old with International Neuroblastoma Staging System (INSS) stage 4, MYCN not amplified ( MYCN-NA), favorable International Neuroblastoma Pathology Classification (INPC), hyperdiploid tumors (12-18mo/Stage4/FavBiology), and 365-546 days old with INSS stage 3, MYCN-NA, and unfavorable INPC tumors (12-18mo/Stage3/ MYCN-NA/Unfav). Log-rank tests compared event-free survival (EFS) and overall survival (OS) curves. RESULTS For 12-18mo/Stage4/FavBiology, 5-year EFS/OS (± SE) before (≤2006; n = 40) versus after (>2006; n = 55) assigned reduction in therapy was similar: 89% ± 5.1%/89% ± 5.1% versus 87% ± 4.6%/94% ± 3.2% ( P = .7; P = .4, respectively). For 12-18mo/Stage3/ MYCN-NA/Unfav, the 5-year EFS and OS were both 100%, before (n = 6) and after (n = 4) 2006. The 12-18mo/Stage4/FavBiology plus 12-18mo/Stage3/ MYCN-NA/Unfav classified as high-risk ≤2006 had an EFS/OS of 91% ± 4.4%/91% ± 4.5% versus 38% ± 1.3%/43% ± 1.3% for all other high-risk patients <3 years old ( P < .0001; P < .0001, respectively). The 12-18mo/Stage4/FavBiology plus 12-18mo/Stage3/ MYCN-NA/Unfav classified as intermediate-risk >2006 had an EFS/OS of 88% ± 4.3%/95% ± 2.9% versus 88% ± 0.9%/95% ± 0.6% for all other intermediate-risk patients <3 years old ( P = .87; P = .85, respectively). CONCLUSION Excellent outcome was maintained among subsets of toddlers with neuroblastoma assigned to reduced treatment after reclassification of risk group from high to intermediate on the basis of new age cutoffs. Importantly, as documented in prior trials, intermediate-risk therapy is not associated with the degree of acute toxicity and late effects commonly observed with high-risk regimens.
Acting on Actionable Mutations in Metastatic Prostate Cancer
Authors: Marshall Catherine H. 
Published: April 2023

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology , to patients seen in their own clinical practice. Approximately a quarter of men with metastatic castration-resistant prostate cancer have genomic alterations within the homologous recombination repair pathway with poly (ADP-ribose) polymerase (PARP) inhibitors as corresponding treatment options. How to incorporate genomic information and associated therapeutic options into treatment decision making and sequencing of therapies in prostate cancer remains challenging. Men with BRCA2 alterations seem to derive the most benefit from PARP inhibitors, and although early treatment in combination with standard therapies has not yet shown an overall survival benefit, there may be other benefits to incorporating PARP inhibitors early for some men.
False Onsager relations
Authors: Campisi Michele 
Published: April 2023

Abstract
Recent research suggests that when a system has a “false time-reversal violation” the Onsager reciprocity relations hold despite the presence of a magnetic field. The purpose of this work is to clarify that the Onsager relations may well be violated in the presence of a “false time-reversal violation”: that rather guarantees the validity of distinct relations, which we dub “false Onsager relations”. We also point out that for quantum systems “false time-reversal violation” is omnipresent and comment that, per se, this has in general no consequence in regard to the validity of Onsager relations, or the more general non-equilibrium fluctuation relations, in the presence of a magnetic field. Our arguments are illustrated with the Heisenberg model of a magnet in an external magnetic field.
Carbohydrate Intake and Oral Glucose Tolerance Test Results in the Postpartum Period
Authors: Rosenberg Emily A , Seely Ellen W , James Kaitlyn , Soffer Marti D , Nelson Stacey , Nicklas Jacinda M , Powe Camille E 
Published: April 2023

Abstract

Context
The American Diabetes Association (ADA) recommends a 3-day preparatory diet prior to a diagnostic oral glucose tolerance test (OGTT), a test often recommended in postpartum individuals with a history of gestational diabetes (GDM).

Objective
Evaluate the relationship between carbohydrate intake and OGTT glucose in 2 cohorts of postpartum individuals.

Methods
We performed analyses of postpartum individuals from 2 prospective studies with recent GDM (Balance after Baby Intervention, BABI, n = 177) or risk factors for GDM (Study of Pregnancy Regulation of INsulin and Glucose, SPRING, n = 104) .We measured carbohydrate intake using 24-hour dietary recalls (SPRING) or Food Frequency Questionnaire (BABI) and performed 2-hour 75-g OGTTs. The main outcome measure was 120-minute post-OGTT glucose.

Results
There was no relationship between carbohydrate intake and 120-minute post-OGTT glucose level in either study population (SPRING: β = 0.03, [−5.5, 5.5] mg/dL, P = .99; BABI: β = −3.1, [−9.5, 3.4] mg/dL, P = .35). Adding breastfeeding status to the model did not change results (SPRING β = −0.14, [−5.7, 5.5] mg/dL, P = .95; BABI β = −3.9, [−10.4, 2.7] mg/dL, P = .25). There was, however, an inverse relationship between glycemic index and 120-minute post OGTT glucose (BABI: β = −1.1, [−2.2, −0.03] mg/dL, P = .04).

Conclusion
Carbohydrate intake is not associated with post-OGTT glucose levels among postpartum individuals. Dietary preparation prior to the OGTT may not be necessary in this population.
Neonatal and Early Infancy Features of Patients With Inactivating PTH/PTHrP Signaling Disorders/Pseudohypoparathyroidism
Authors: Del Sindaco Giulia , Berkenou Jugurtha , Pagnano Angela , Rothenbuhler Anya , Arosio Maura , Mantovani Giovanna , Linglart Agnès 
Published: April 2023

Abstract

Background
Pseudohypoparathyroidism (PHP) and related disorders newly referred to as inactivating PTH/PTHrP signaling disorders (iPPSD) are rare endocrine diseases. Many clinical features including obesity, neurocognitive impairment, brachydactyly, short stature, parathyroid hormone (PTH) resistance, and resistance to other hormones such as thyroid-stimulating hormone (TSH) have been well described, yet they refer mainly to the full development of the disease during late childhood and adulthood.

Objective
A significant delay in diagnosis has been reported; therefore, our objective is to increase awareness on neonatal and early infancy presentation of the diseases. To do so, we analyzed a large cohort of iPPSD/PHP patients.

Methods
We included 136 patients diagnosed with iPPSD/PHP. We retrospectively collected data on birth and investigated the rate of neonatal complications occurring in each iPPSD/PHP category within the first month of life.

Results
Overall 36% of patients presented at least one neonatal complication, far more than the general population; when considering only the patients with iPPSD2/PHP1A, it reached 47% of the patients. Neonatal hypoglycemia and transient respiratory distress appeared significantly frequent in this latter group, ie, 10.5% and 18.4%, respectively. The presence of neonatal features was associated with earlier resistance to TSH (P &lt; 0.001) and with the development of neurocognitive impairment (P = 0.02) or constipation (P = 0.04) later in life.

Conclusion
Our findings suggest that iPPSD/PHP and especially iPPSD2/PHP1A newborns require specific care at birth because of an increased risk of neonatal complications. These complications may predict a more severe course of the disease; however, they are unspecific which likely explains the diagnostic delay.
An Increase in Plasma Sodium Levels Is Associated With an Increase in Osteoblast Function in Chronic SIAD
Authors: Monnerat Sophie , Refardt Julie , Potasso Laura , Meier Christian , Christ-Crain Mirjam 
Published: April 2023

Abstract

Context
Hyponatremia is associated with increased risk for osteoporosis. Preclinical studies in untreated hyponatremia suggest osteoclast upregulation, whereas a clinical study showed improved osteoblast function after hyponatremia normalization in hospitalized patients with syndrome of inappropriate antidiuresis (SIAD).

Objective
This work aimed to investigate the effect of an increase in sodium on bone turnover, that is, the ratio of the osteoblast marker procollagen type 1 N-terminal propeptide (P1NP) to the osteoclast marker cross-linked C-terminal telopeptide of type 1 collagen (CTX), in outpatients with chronic SIAD.

Methods
A predefined secondary analysis was conducted of the 2-month double-blind, crossover, placebo-controlled SANDx Trial (NCT03202667) performed from December 2017 to August 2021. Participants included 11 outpatients with chronic SIAD: 6 women, median age 73 years, who received a 4-week treatment with 25-mg empagliflozin or placebo. Main outcome measures included the relationship between the change in bone formation index (BFI), defined as P1NP/CTX, and the change in plasma sodium levels.

Results
Changes in sodium were positively correlated with changes in BFI and P1NP (BFI: ρ=.55; P &lt; .001; P1NP: ρ=.45; P = .004) but not with CTX (P = .184) and osteocalcin (P = .149). A sodium increase of 1 mmol/l was associated with an increase of 5.21 in BFI (95% CI, 1.41-9.00; P = .013) and with an increase of 1.48 µg/l in P1NP (95% CI, .26-2.62; P = .03). The effect of sodium change on bone markers was independent of the study medication empagliflozin.

Conclusion
An increase in plasma sodium levels in outpatients with chronic hyponatremia due to SIAD, even when mild, was associated with an increase in bone formation index (P1NP/CTX) triggered by an increase in P1NP, a surrogate marker of osteoblast function.
GIPC3 couples to MYO6 and PDZ domain proteins, and shapes the hair cell apical region
Authors: Chatterjee Paroma , Morgan Clive P. , Krey Jocelyn F. , Benson Connor , Goldsmith Jennifer , Bateschell Michael , Ricci Anthony J. , Barr-Gillespie Peter G. 
Published: April 2023

ABSTRACT
GIPC3 has been implicated in auditory function. Here, we establish that GIPC3 is initially localized to the cytoplasm of inner and outer hair cells of the cochlea and then is increasingly concentrated in cuticular plates and at cell junctions during postnatal development. Early postnatal Gipc3KO/KO mice had mostly normal mechanotransduction currents, but had no auditory brainstem response at 1 month of age. Cuticular plates of Gipc3KO/KO hair cells did not flatten during development as did those of controls; moreover, hair bundles were squeezed along the cochlear axis in mutant hair cells. Junctions between inner hair cells and adjacent inner phalangeal cells were also severely disrupted in Gipc3KO/KO cochleas. GIPC3 bound directly to MYO6, and the loss of MYO6 led to altered distribution of GIPC3. Immunoaffinity purification of GIPC3 from chicken inner ear extracts identified co-precipitating proteins associated with adherens junctions, intermediate filament networks and the cuticular plate. Several of immunoprecipitated proteins contained GIPC family consensus PDZ-binding motifs (PBMs), including MYO18A, which bound directly to the PDZ domain of GIPC3. We propose that GIPC3 and MYO6 couple to PBMs of cytoskeletal and cell junction proteins to shape the cuticular plate.
Changes in Immature Reticulocytes Aid the Indirect Detection of Microdose Recombinant Erythropoietin Use in Men and Women
Authors: BREENFELDT ANDERSEN ANDREAS , BEJDER JACOB , BONNE THOMAS CHRISTIAN , GRAAE JONATHAN , SEIER SØREN , NORDSBORG NIKOLAI BAASTRUP 
Published: April 2023

ABSTRACT

Purpose
We investigated whether immature reticulocyte fraction (IRF) and the immature reticulocytes to red blood cells ratio (IR/RBC) are sensitive and specific biomarkers for microdose recombinant human erythropoietin (rHuEPO) and whether the inclusion of reticulocyte percentage (RET%) and the algorithm “abnormal blood profile score (ABPS)” increased the athlete biological passport (ABP) sensitivity compared with hemoglobin concentration ([Hb]) and the OFF-hr score ([Hb]–60 × √RET%).

Methods
Forty-eight (♀ = 24, ♂ = 24) participants completed a 2-wk baseline period followed by a 4-wk intervention period with three weekly intravenous injections of 9 IU·kg−1·bw−1 epoetin β (♀ = 12, ♂ = 12) or saline (0.9% NaCl, ♀ = 12, ♂ = 12) and a 10-d follow-up. Blood samples were collected weekly during baseline and intervention as well as 3, 5, and 10 d after treatment.

Results
The rHuEPO treatment increased [Hb] (time–treatment, P < 0.001), RET% (time–treatment, P < 0.001), IRF (time–treatment, P < 0.001) and IR/RBC (time–treatment, P < 0.001). IRF and IR/RBC were up to ~58% (P < 0.001) and ~141% (P < 0.001) higher compared with placebo, and calculated thresholds provided a peak sensitivity across timepoints of 58% and 54% with ~98% specificity, respectively. To achieve >99% specificity for IRF and IR/RBC, sensitivity was reduced to 46% and 50%, respectively. Across all timepoints, the addition of RET% and ABPS to the ABP increased sensitivity from 29% to 46%. Identification of true-positive outliers obtained via the ABP and IRF and IR/RBC increased sensitivity across all timepoints to 79%.

Conclusions
In summary, IRF, IR/RBC, RET% and ABPS are sensitive and specific biomarkers for microdose rHuEPO in both men and women and complement the ABP.
The lung cancers: staging and response, CT, 18F-FDG PET/CT, MRI, DWI: review and new perspectives
Authors: Owens Cara , Hindocha Sumeet , Lee Richard , Millard Thomas , Sharma Bhupinder 
Published: April 2023

Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer deaths in both sexes combined. Recent years have seen major advances in the diagnostic and treatment options for patients with non-small-cell lung cancer (NSCLC), including the routine use of 2-deoxy-2[18F]-fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in staging and response evaluation, minimally invasive endoscopic biopsy, targeted radiotherapy, minimally invasive surgery, and molecular and immunotherapies. In this review, the central roles of CT and 18F-FDG PET/CT in staging and response in both NSCLC and malignant pleural mesothelioma (MPM) are critically assessed. The Tumour Node Metastases (TNM-8) staging systems for NSCLC and MPM are presented with critical appraisal of the strengths and pitfalls of imaging. Overviews of the Response Evaluation Criteria in Solid Tumours (RECIST 1.1) for NSCLC and the modified RECIST criteria for MPM are provided, together with discussion of the benefits and limitations of these anatomical-based tools. Metabolic response assessment (not evaluated by RECIST 1.1) will be explored. We introduce the Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST 1.0) to include its advantages and challenges. The limitations of both anatomical and metabolic assessment criteria when applied to NSCLC treated with immunotherapy and the important concept of pseudoprogression are addressed with reference to immune RECIST (iRECIST). Separate consideration is given to the diagnosis and follow up of solitary pulmonary nodules with reference to the British Thoracic Society guidelines and Fleischner guidelines and use of the Brock (CT-based) and Herder (addition of 18F-FDG PET/CT) models for assessing malignant potential. We discuss how these models inform decisions by the multidisciplinary team, including referral of suspicious nodules for non-surgical management in patients unsuitable for surgery. We briefly outline current lung screening systems being used in the UK, Europe and North America. Emerging roles for MRI in lung cancer imaging are reviewed. The use of whole-body MRI in diagnosing and staging NSCLC is discussed with reference to the recent multicentre Streamline L trial. The potential use of diffusion-weighted MRI to distinguish tumour from radiotherapy-induced lung toxicity is discussed. We briefly summarise the new PET-CT radiotracers being developed to evaluate specific aspects of cancer biology, other than glucose uptake. Finally, we describe how CT, MRI and 18F-FDG PET/CT are moving from primarily diagnostic tools for lung cancer towards having utility in prognostication and personalised medicine with the agency of artificial intelligence.
SMA Therapy in Poland: New Hopes and Challenges
Authors: Welian Iwona , Gendek Karolina , Jastrzębska Ilona , Maliszewska Karolina , Chrościńska-Krawczyk Magdalena 
Published: April 2023

Abstract: Spinal muscular atrophy (SMA) is a genetically inherited disease whose symptoms appear in children at a fairly early age. The main cause of the disease is a mutation of the SMN1 gene, which causes the lack of production of SMN This results in the disappearance of motoneurons, which consequently leads to the disappearance of the patient's ability to move and his death. An important element of coping with the disease is its early detection in newborn screening, because the earlier we start the drug, the greater the chance that the patient will maintain motor efficiency. The article describes treatment options for children in Poland, i. e. the use of such drugs as Nusinersen, which increases the amount of SMN protein, gene therapy Onasemnogen aeparvovec, which increases the amount of SMN gene, Ridisplam, which increases the amount of SMN protein, and salbutamol, which helps patients to breathe. The article also provides information about new drug therapies for the treatment of SMA and the stage of clinical trials at which they are currently being developed. It is important to look for new solutions in the treatment of SMA.
Objective: To familiarize the readers of the article with the problems of SMA treatment in Poland, as well as to broaden their knowledge of new available drugs for the treatment of this disease.