bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating bone marrow dosimetry with the addition of bone marrow structures to the medical internal radiation dose phantom
Authors: Ferrone Kristine L. , Willis Charles E. , Guan Fada , Ma Jingfei , Peterson Leif E. , Kry Stephen F. 
Published: March 2023

AbstractBackgroundReliable estimates of radiation dose to bone marrow are critical to understanding the risk of radiation‐induced cancers. Although the medical internal radiation dose phantom is routinely used for dose estimation, bone marrow is not defined in the phantom. Consequently, methods of indirectly estimating bone marrow dose have been implemented based on dose to surrogate volumes or average dose to soft tissue.MethodsIn this study, new bone marrow structures were implemented and evaluated to the medical internal radiation dose phantom in Geant4, offering improved fidelity. The dose equivalent to the bone marrow was calculated across medical, occupational, and space radiation exposure scenarios, and compared with results using prior indirect estimation methods.ConclusionOur results show that bone marrow dose may be overestimated by up to a factor of three when using the traditional methods when compared with the improved fidelity medical internal radiation dose method, specifically at clinical x‐ray energies.
Ginkgolide A targets forkhead box O1 to protect against lipopolysaccharide‐induced septic cardiomyopathy
Authors: Wang Luyang , Zhao Yunxi , Su Zhenyang , Zhao Kun , Li Peng , Xu Tianhua 
Published: March 2023

AbstractGinkgolide A (GA), a main terpenoid extracted from Ginkgo biloba, possesses biological activities such as anti‐inflammatory, anti‐tumor, and liver protection. However, the inhibitory effects of GA on septic cardiomyopathy remain unclear. This study aimed to explore the effects and mechanisms of GA in countering sepsis‐induced cardiac dysfunction and injury. In lipopolysaccharide (LPS)‐induced mouse model, GA alleviated mitochondrial injury and cardiac dysfunction. GA also significantly reduced the production of inflammatory and apoptotic cells, the release of inflammatory indicators, and the expression of oxidative stress‐associated and apoptosis‐associated markers, but increased the expression of pivotal antioxidant enzymes in hearts from LPS group. These results were consistent with those of in vitro experiments based on H9C2 cells. Database analysis and molecular docking suggested that FoxO1 was targeted by GA, as shown by stable hydrogen bonds formed between GA with SER‐39 and ASN‐29 of FoxO1. GA reversed LPS‐induced downregulation of nucleus FoxO1 and upregulation of p‐FoxO1 in H9C2 cells. FoxO1 knockdown abolished the protective properties of GA in vitro. KLF15, TXN2, NOTCH1, and XBP1, as the downstream genes of FoxO1, also exerted protective effects. We concluded that GA could alleviate LPS‐induced septic cardiomyopathy via binding to FoxO1 to attenuate cardiomyocyte inflammation, oxidative stress, and apoptosis.
Body mass index and natriuretic peptides trends before and after left ventricular assist device
Authors: Schultz Jessica , Vest Amanda R. , Masotti Maria , Hoeg Austin , Teigen Levi , John Ranjit , Shaffer Andrew , Alexy Tamas , Martin Cindy , Cogswell Rebecca 
Published: March 2023

AbstractBackgroundIt is unknown to what degree of sarcopenia related to heart failure (HF) is reversible with resolution of the HF syndrome. We evaluated whether (1) weight loss prior to left ventricular assist device (LVAD) is associated with pre‐operative sarcopenia as quantified on pre‐operative chest CTs and (2) determine the relationship between weight recovery (increase) after LVAD implantation and reduction of NT‐proBNP levels.MethodsIn a large single‐centre cohort (n = 502), CT measures of sarcopenia (pectoralis muscle mass indexed to body surface area and tissue attenuation) were correlated with pre‐LVAD BMI trend (n = 190). BMI and NT‐proBNP trends before and after LVAD implantation were evaluated (n = 403). Linear effects modelling was performed to test the association between NT‐proBNP and BMI trends.ResultsA downtrending BMI prior to LVAD was associated with pectoralis muscle tissue attenuation (P < 0.05). BMI declined prior to LVAD, declined further early post‐implant, and then increased between 100 and 300 days post‐implant (average per cent change in BMI in Year 1, 7.6%, 95% CI: 6.3–8.8%). NT‐proBNP decreased during the first 100 post LVAD days (−5.4%, 95% CI: −6.6 to −4.2%). Post‐LVAD NT‐proBNP and BMI trends were significantly associated, with a decrease of 1 unit log NT‐proBNP associated with an increase in BMI of 0.81 kg/m2 (CI: 0.53–1.09, P < .001). The rise in post‐LVAD BMI occurred after the reduction in NT‐proBNP levels. Patients who failed to gain weight post‐LVAD had the highest 6‐month post‐LVAD natriuretic peptides (lowest per cent BMI gain tertile NT‐proBNP: 2208 vs. highest 1635 pg/mL, P < 0.001).ConclusionsWeight recovery during LVAD support occurs after the reduction in natriuretic peptide levels. Failure to gain weight during LVAD support was associated with persistently elevated natriuretic peptide levels. These data collectively suggest that recovery of body mass may be dependent upon recovery of the HF syndrome.
Finite‐time sampled‐data output feedback stabilization for a class of feed‐forward non‐holonomic systems
Authors: Mao Jun , Zou Wencheng , He Wenmin , Xiang Zhengrong 
Published: March 2023

AbstractThis article considers a finite‐time sampled‐data output feedback stabilization problem for a class of feed‐forward non‐holonomic systems. Due to that the states of the focused system are unavailable, a reduced‐order observer is designed to estimate the unavailable states with the sampled output detection of the non‐holonomic system, and two finite‐time sampled‐data stabilizers are respectively constructed by combining the backstepping and adding a power integral techniques. Based on the stepped and switching control strategies, the corresponding closed‐loop system can be globally finite‐time stable by the constructed stabilizers with allowable design constants and sampling period, and this can be proved by choosing an appropriate Lyapunov function candidate. In the end, two simulation examples, which include a numerical and a practical examples, are provided to verify the effectiveness of the proposed finite‐time stabilization method.
When and how the implementation of green human resource management and data‐driven culture to improve the firm sustainable environmental development?
Authors: Awan Usama , Braathen Petter , Hannola Lea 
Published: March 2023

AbstractThe process by which manufacturing firms incorporate data‐driven culture into existing routines and use them to generate organizational learning (OL) and improve sustainable environmental development is a central concern in the green management literature. For this, the study examines how and to what extent data‐driven culture contributes to developing and integrating organizational learning capability (OLC) for environmental performance (EP). The analysis is informed by theory on a knowledge‐based view and dynamic capabilities. We propose a conceptual model that examines the moderation‐mediation impact of data‐driven culture on green human resource management (HRM) and EP through OLC. We empirically test our model using primary survey data from 274 manufacturing enterprises in Pakistan. Partial least‐square structural equation modeling and moderated‐mediation regression analysis were used to assess the hypothesized correlations between the variables. The study implies that green HRM practices can facilitate OLC to achieve and gain high EP in contexts of rapid change. Further, the findings show that firms adopting a data‐driven culture may have better EP. Having a robust data‐driven culture makes organizations focus more on learning capability development that promotes increased EP. This research offers several significant contributions to green management literature and theory. Managers should promote green human resource strategies and the importance of data‐driven culture for greening organizations. In today's data‐rich and unpredictable world, these empirical studies provide relevant and practical advice for managers to implement data‐driven culture to make shift and support sustainable development issues.
Crystals of Aliphatic Derivatives of [Cu(acac)2] have Distinct Atomic‐Scale Mechanisms of Bending
Authors: Thompson Amy J. , Powell Joshua A. , Melville Jamie N. , McMurtrie John C. , Clegg Jack K. 
Published: March 2023

AbstractMolecular crystals displaying elastic flexibility have important applications in the fields of optoelectronics and nanophotonic technologies. Understanding the mechanisms by which these materials bend is critical to the design of future materials incorporating these properties. Based on the known elastic properties of bis(acetylacetonato)copper(II), a series of 14 aliphatic derivatives are synthesized and crystallized. All those which grew in a needle morphology display noticeable elasticity, with 1D chains of π‐stacked molecules parallel to the long metric length of the crystal a consistent crystallographic feature. Crystallographic mapping is used to measure the mechanism of elasticity at an atomic‐scale. Symmetric derivatives with ethyl and propyl side chains are found to have different mechanisms of elasticity, which are further distinguished from the previously reported mechanism of bis(acetylacetonato)copper(II). While crystals of bis(acetylacetonato)copper(II) are known to bend elastically via a molecular rotation mechanism, the elasticity of the compounds presented is facilitated by expansion of their π‐stacking interactions.
Photothermal Responsive Digital Polymerase Chain Reaction Resolving Exosomal microRNAs Expression in Liver Cancer
Authors: Parvin Rokshana , Zhang Lexiang , Zu Yan , Ye Fangfu 
Published: March 2023

AbstractExosomal microRNAs have been studied as a good source of noninvasive biomarkers due to their functions in genetic exchange between cells and have been already well documented in many biological activities; however, inaccuracy remains a key challenge for liver cancer surveillance. Herein, a versatile duplex photothermal digital polymerase chain reaction (PCR) strategy combined with a lipid nanoparticle‐based exosome capture approach is proposed to profile microRNAs expression through a 3‐h easy‐to‐operate process. The microfluidically‐generated molybdenum disulfide‐nanocomposite‐doped gelatin microcarriers display attractive properties as a 2–4 °C s−1 ramping‐up rate triggered by near‐infrared and reversible sol–gel transforming in step with PCR activation. To achieve PCR thermocycling, the corresponding irradiation coordinating with fan cooling are automatically performed via a homemade control module with programs. Thus, taking the multiplexing capability of dual‐color labeling, 19–31 folds higher in exosomal microRNA‐200b‐3p and microRNA‐21‐5p, and tenfold lower in microRNA‐22‐3p expressions relative to the control microRNA‐26a‐5p are quantified in two liver cancer cells (Huh7 and HepG2) than in those from the healthy cells. It is believed that this exosomal microRNA genotyping method would be highly applicable for liver cancer diagnostics.
Multifunctional Nanocrystalline‐Assembled Porous Hierarchical Material and Device for Integrating Microwave Absorption, Electromagnetic Interference Shielding, and Energy Storage
Authors: Yao Lihua , Wang Yuchang , Zhao Jianguo , Zhu Youqi , Cao Maosheng 
Published: March 2023

AbstractMultifunctional applications including efficient microwave absorption and electromagnetic interference (EMI) shielding as well as excellent Li‐ion storage are rarely achieved in a single material. Herein, a multifunctional nanocrystalline‐assembled porous hierarchical NiO@NiFe2O4/reduced graphene oxide (rGO) heterostructure integrating microwave absorption, EMI shielding, and Li‐ion storage functions is fabricated and tailored to develop high‐performance energy conversion and storage devices. Owing to its structural and compositional advantages, the optimized NiO@NiFe2O4/15rGO achieves a minimum reflection loss of −55 dB with a matching thickness of 2.3 mm, and the effective absorption bandwidth is up to 6.4 GHz. The EMI shielding effectiveness reaches 8.69 dB. NiO@NiFe2O4/15rGO exhibits a high initial discharge specific capacity of 1813.92 mAh g−1, which reaches 1218.6 mAh g−1 after 289 cycles and remains at 784.32 mAh g−1 after 500 cycles at 0.1 A g−1. In addition, NiO@NiFe2O4/15rGO demonstrates a long cycling stability at high current densities. This study provides an insight into the design of advanced multifunctional materials and devices and provides an innovative method of solving current environmental and energy problems.
From Meso to Macro: Controlling Hierarchical Porosity in Supraparticle Powders
Authors: Sultan Umair , Götz Alexander , Schlumberger Carola , Drobek Dominik , Bleyer Gudrun , Walter Teresa , Löwer Erik , Peuker Urs Alexander , Thommes Matthias , Spiecker Erdmann , Apeleo Zubiri Benjamin , Inayat Alexandra , Vogel Nicolas 
Published: March 2023

AbstractA drying droplet containing colloidal particles can consolidate into a spherical assembly called a supraparticle. Such supraparticles are inherently porous due to the spaces between the constituent primary particles. Here, the emergent, hierarchical porosity in spray‐dried supraparticles is tailored via three distinct strategies acting at different length scales. First, mesopores (<10 nm) are introduced via the primary particles. Second, the interstitial pores are tuned from the meso‐ (35 nm) to the macro scale (250 nm) by controlling the primary particle size. Third, defined macropores (>100 nm) are introduced via templating polymer particles, which can be selectively removed by calcination. Combining all three strategies creates hierarchical supraparticles with fully tailored pore size distributions. Moreover, another level of the hierarchy is added by fabricating supra‐supraparticles, using the supraparticles themselves as building blocks, which provide additional pores with micrometer dimensions. The interconnectivity of the pore networks within all supraparticle types is investigated via detailed textural and tomographic analysis. This work provides a versatile toolbox for designing porous materials with precisely tunable, hierarchical porosity from the meso‐ (3 nm) to the macroscale (≈10 µm) that can be utilized for applications in catalysis, chromatography, or adsorption.
Defect‐Rich PdIr Bimetallene Nanoribbons with Interatomic Charge Localization for Isopropanol‐Assisted Seawater Splitting
Authors: Liu Songliang , Zhang Hugang , Yu Hongjie , Deng Kai , Wang Ziqiang , Xu You , Wang Liang , Wang Hongjing 
Published: March 2023

AbstractMetallene with outstanding physicochemical properties is an efficient two‐dimensional electrocatalysts for sustainable hydrogen (H2) production applications. However, the controllable fabrication of extended atomically thin metallene nanoribbons remains a formidable challenge. Herein, this work proposes a controllable preparation strategy for atomically thin defect‐rich PdIr bimetallene nanoribbons (PdIr BNRs) with a thickness of only 1.5 nm for the efficient and stable isopropanol‐assisted seawater electrolytic H2 production. When using PdIr BNRs as catalyst to build an isopropanol‐assisted seawater electrolysis system, a voltage of only 0.38 V is required at @10 mA cm−2 to achieve energy‐saving H2 production, while producing high value‐added acetone at the anode. The aberration‐corrected high‐resolution transmission electron microscopy (HRTEM) clearly reveals that the PdIr BNRs possess abundant structural defects, which can additionally serve as highly catalytically active sites. Density functional theory (DFT) calculations combined with X‐ray absorption spectroscopy studies reveal that the introduction of Ir atoms can induce the formation of a localized charge region and shift the d‐band center of Pd down, thereby reducing the adsorption energy on the catalyst in favor of the rapid desorption of H2. This work opens the way for the controllable design and construction of defect‐rich atomically thin metallene nanoribbons for efficient electrocatalytic applications.
Cation–π Interaction Trigger Supramolecular Hydrogelation of Peptide Amphiphiles
Authors: Chen Shuang , Li Zenghui , Zhang Chunhui , Wu Xia , Wang Wenjie , Huang Qingjun , Chen Weiyu , Shi Junfeng , Yuan Dan 
Published: March 2023

AbstractAs an important noncovalent interaction, cation–π interaction plays an essential role in a broad area of biology and chemistry. Despite extensive studies in protein stability and molecular recognition, the utilization of cation–π interaction as a major driving force to construct supramolecular hydrogel remains uncharted. Here, a series of peptide amphiphiles are designed with cation–π interaction pairs that can self‐assemble into supramolecular hydrogel under physiological condition. The influence of cation–π interaction is thoroughly investigated on peptide folding propensity, morphology, and rigidity of the resultant hydrogel. Computational and experimental results confirm that cation–π interaction could serve as a major driving force to trigger peptide folding, resultant β‐hairpin peptide self‐assembled into fibril‐rich hydrogel. Furthermore, the designed peptides exhibit high efficacy on cytosolic protein delivery. As the first case of using cation–π interactions to trigger peptide self‐assembly and hydrogelation, this work provides a novel strategy to generate supramolecular biomaterials.
Solid‐State Electron Transport Through Carbon Dots Junctions: The Role of Boron and Phosphorus Doping
Authors: Toren Yuval , Vilan Ayelet , Amdursky Nadav 
Published: March 2023

AbstractCarbon dots (CDs) are a new class of nanoparticles that gained widespread attention recently because of their easy preparation, water solubility, biocompatibility, and bright luminescence, leading to their integration in various applications. Despite their nm‐scale and proven electron transfer capabilities, the solid‐state electron transport (ETp) across single CDs was never explored. Here, a molecular junction configuration is used to explore the ETp across CDs as a function of their chemical structure using both DC‐bias current–voltage and AC‐bias impedance measurements. CDs are used with Nitrogen and Sulfur as exogenous atoms and doped with small amounts of Boron and Phosphorous. It is shown that the presence of P and B highly improves the ETp efficiency across the CDs, yet without an indication of a change in the dominant charge carrier. Instead, structural characterizations reveal significant changes in the chemical species across the CDs: the formation of sulfonates and graphitic Nitrogen. Temperature‐dependent measurements and normalized differential conductance analysis reveal that the ETp mechanism across the CDs behaves as tunneling, which is common to all CDs used here. The study shows that the conductivity of CDs is on par with that of sophisticated molecular wires, suggesting CDs as new ‘green’ candidates for molecular electronics applications.
Interfacial Designs of MXenes for Mild Aqueous Zinc‐Ion Storage
Authors: Guo Rui , Chen Chaofan , Bannenberg Lars J. , Wang Hao , Liu Haozhe , Yu Minghao , Sofer Zdenek , Lei Zhibin , Wang Xuehang 
Published: March 2023

AbstractLimited Li resources, high cost, and safety risks of using organic electrolytes have stimulated a strong motivation to develop non‐Li aqueous batteries. Aqueous Zn‐ion storage (ZIS) devices offer low‐cost and high‐safety solutions. However, their practical applications are at the moment restricted by their short cycle life arising mainly from irreversible electrochemical side reactions and processes at the interfaces. This review sums up the capability of using 2D MXenes to increase the reversibility at the interface, assist the charge transfer process, and thereby improve the performance of ZIS. First, they discuss the ZIS mechanism and irreversibility of typical electrode materials in mild aqueous electrolytes. Then, applications of MXenes in different ZIS components are highlighted, including as electrodes for Zn2+ intercalation, protective layers of Zn anode, hosts for Zn deposition, substrates, and separators. Finally, perspectives are put forward on further optimizing MXenes to improve the ZIS performance.
Alternatives Verfahren zur Ermittlung des Schadensäquivalenzfaktors nach prEN 1993‐2
Authors: Oberhaidinger Florian , Westenhöfer Annika , Mensinger Martin 
Published: March 2023

AbstractMit der Einführung der 2. Generation der DIN EN 1993‐2 – derzeit prEN 1993‐2 – steht den Planern in Anhang F ein zusätzliches Verfahren für die Ermittlung des Schadensäquivalenzfaktors λ von Straßenbrücken zur Verfügung. Dieses erweitert den Anwendungsbereich des vereinfachten Ermüdungslastmodells, berücksichtigt aktuelle europäische Verkehrsdaten und ermöglicht bei geringem Verkehrsaufkommen ( Nobs ≤ 0,5 ⋅ 106) v. a. für Kerbdetails im Feldbereich eine durchaus wirtschaftlichere Ermüdungsbemessung. Ein Vergleich des Verfahrens mit den aktuellen Regelungen unter Berücksichtigung des ARS22/2012 zeigt zum Teil signifikante Unterschiede bei der Ermittlung des λ‐Faktors. Für eine in Deutschland praxistaugliche Anwendung sollten den Planern daher normative Hinweise für die Auswahl des Verfahrens sowie für die Wahl eines geeigneten Verkehrsaufkommens Nobs und Fahrzeuggesamtgewichts Qm1 auf Basis aktueller Bestands‐ und Prognoseszenarien an die Hand gegeben werden. Das an der École Polytechnique Fédérale de Lausanne (EPFL) entwickelte Verfahren wird derzeit in deutschen Fachgremien noch kontrovers diskutiert.
Integrale Spundwandwiderlager für modulare Verbundbrücken
Authors: Rittich Nils , Wolters Kevin , Feldmann Markus 
Published: March 2023

AbstractDie alternde Bestandsinfrastruktur von Brückenbauwerken in Deutschland hat zu einem massiven Sanierungs‐ und Erneuerungsbedarf geführt. Im Sinne einer nachhaltigen Ressourcennutzung sind neben den reinen Herstellkosten auch die Lebenszyklus‐ und volkswirtschaftlichen Kosten zu beachten, was in bisherigen Entwurfskonzepten meist nur ungenügend berücksichtigt wird. Modulare Verbundbrücken mit integralen Spundwandwiderlagern bieten in dieser Hinsicht Vorteile. Da hierfür jedoch noch keine standardisierte Bemessungspraxis existiert, werden bisher nur einzelne Bestandteile dieser Bauweise in wenigen Pilotprojekten ausgenutzt. Um an dieser Stelle entgegenzuwirken, werden im Rahmen des FOSTA‐Forschungsprojekts P1521 zwei Konzepte zur Ausführung einer quasimonolithischen Verbindung zwischen Verbundfertigteilträgern und Spundwänden als Gründungselemente entwickelt. Um eine möglichst breite Anwendungspraxis zu erzielen, wird zum einen ein teilmomententragfähiger Anschluss für Spannweiten bis ca. 25 m, zum anderen ein vollmomententragfähiger Anschluss für größere Spannweiten bis ca. 45 m untersucht. Hierfür werden neben experimentellen Untersuchungen des Anschlussdetails in der Rahmenecke umfangreiche numerische Untersuchungen und Parameterstudien durchgeführt, um maßgebliche Einflussparameter auf die Steifigkeit und Tragfähigkeit des Details zu identifizieren. Die Auswertung der Versuche zeigt eine durchaus hohe Tragfähigkeit sowie ein gutmütiges Nachbruchverhalten der Verbindung.