bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of an MCL-1-related prognostic signature and inhibitors screening for glioblastoma
Authors: Zhang Ao , Guo Zhen , Ren Jia-xin , Chen Hongyu , Yang Wenzhuo , Zhou Yang , Pan Lin , Chen Zhuopeng , Ren Fei , Chen Youqi , Zhang Menghan , Peng Fei , Chen Wanting , Wang Xinhui , Zhang Zhiyun , Wu Hui 
Published: July 2023

Introduction: The effect of the conventional treatment methods of glioblastoma (GBM) is poor and the prognosis of patients is poor. The expression of MCL-1 in GBM is significantly increased, which shows a high application value in targeted therapy. In this study, we predicted the prognosis of glioblastoma patients, and therefore constructed MCL-1 related prognostic signature (MPS) and the development of MCL-1 small molecule inhibitors.Methods: In this study, RNA-seq and clinical data of 168 GBM samples were obtained from the TCGA website, and immunological analysis, differential gene expression analysis and functional enrichment analysis were performed. Subsequently, MCL-1-associated prognostic signature (MPS) was constructed and validated by LASSO Cox analysis, and a nomogram was constructed to predict the prognosis of patients. Finally, the 17931 small molecules downloaded from the ZINC15 database were screened by LibDock, ADME, TOPKAT and CDOCKER modules and molecular dynamics simulation in Discovery Studio2019 software, and two safer and more effective small molecule inhibitors were finally selected.Results: Immunological analysis showed immunosuppression in the MCL1_H group, and treatment with immune checkpoint inhibitors had a positive effect. Differential expression gene analysis identified 449 differentially expressed genes. Build and validate MPS using LASSO Cox analysis. Use the TSHR HIST3H2A, ARGE OSMR, ARHGEF25 build risk score, proved that low risk group of patients prognosis is better. Univariate and multivariate analysis proved that risk could be used as an independent predictor of patient prognosis. Construct a nomogram to predict the survival probability of patients at 1,2,3 years. Using a series of computer-aided techniques, two more reasonable lead compounds ZINC000013374322 and ZINC000001090002 were virtually selected. These compounds have potential inhibitory effects on MCL-1 and provide a basis for the design and further development of MCL-1 specific small molecule inhibitors.Discussion: This study analyzed the effect of MCL-1 on the prognosis of glioblastoma patients from the perspective of immunology, constructed a new prognostic model to evaluate the survival rate of patients, and further screened 2 MCL-1 small molecule inhibitors, which provides new ideas for the treatment and prognosis of glioblastoma.
Use of the first-acquired language modulates pupil size in the processing of island constraint violations
Authors: Martohardjono Gita , Johns Michael A. , Franciotti Pamela , Castillo Daniela , Porru Ilaria , Lowry Cass 
Published: July 2023

IntroductionTraditional studies of the population called “heritage speakers” (HS) have treated this group as distinct from other bilingual populations, e.g., simultaneous or late bilinguals (LB), focusing on group differences in the competencies of the first-acquired language or “heritage language”. While several explanations have been proposed for such differences (e.g., incomplete acquisition, attrition, differential processing mechanisms), few have taken into consideration the individual variation that must occur, due to the fluctuation of factors such as exposure and use that characterize all bilinguals. In addition, few studies have used implicit measures, e.g., psychophysiological methods (ERPs; Eye-tracking), that can circumvent confounding variables such as resorting to conscious metalinguistic knowledge.MethodologyThis study uses pupillometry, a method that has only recently been used in psycholinguistic studies of bilingualism, to investigate pupillary responses to three syntactic island constructions in two groups of Spanish/English bilinguals: heritage speakers and late bilinguals. Data were analyzed using generalized additive mixed effects models (GAMMs) and two models were created and compared to one another: one with group (LB/HS) and the other with groups collapsed and current and historical use of Spanish as continuous variables.ResultsResults show that group-based models generally yield conflicting results while models collapsing groups and having usage as a predictor yield consistent ones. In particular, current use predicts sensitivity to L1 ungrammaticality across both HS and LB populations. We conclude that individual variation, as measured by use, is a critical factor tha must be taken into account in the description of the language competencies and processing of heritage and late bilinguals alike.
How job demands and job resources contribute to our overall subjective well-being
Authors: Claes Sara , Vandepitte Sophie , Clays Els , Annemans Lieven 
Published: July 2023

ObjectivesHow the work environment contributes to employees’ overall subjective well-being remains inadequately explored. Building upon the seminal Job Demands-Resources model, this study aims to test a complex model that combines leadership, job demands, and job resources, as factors contributing either indirectly (via job satisfaction) or directly to employees’ subjective well-being (SWB).MethodsThe cross-sectional data (N = 1,859) of the Belgian National happiness study (2020) were used. Leadership (satisfaction with leadership; perceived supervisor support), job demands (role conflict; job insecurity; work-private conflict; perceived working conditions), job resources (autonomy; relatedness; competence; skill utilization; personal growth), job satisfaction and subjective well-being (life evaluation; positive affect; negative affect) were assessed via self-report questionnaires. The proposed model investigates the direct impact of job demands and resources on SWB, as well as the indirect impact with job satisfaction as mediating factor, and was tested using the Structural Equation Modeling technique.ResultsFindings supported the proposed model. Both job demands and job resources have a direct relationship with SWB. Job resources are positively related to overall SWB, whereas job demands negatively affected SWB. Moreover, job resources are more strongly related to SWB compared to job demands. The demands and resources also indirectly contribute to employee’s SWB via job satisfaction as job satisfaction appeared to mediate these relationships.ConclusionThe current study shows that both job demands and resources directly and indirectly contribute to employees’ SWB. Creating a supportive and healthy work environment is thus of paramount importance in order to foster employees’ SWB. In particular, investing in improving job resources may be a fruitful approach to promote employees’ overall subjective well-being.
Therapists’ experiences with providing guided internet-delivered cognitive behavioral therapy for patients with mild and moderate depression: a thematic analysis
Authors: Børtveit Line , Nordgreen Tine , Nordahl-Hansen Anders 
Published: July 2023

IntroductionGuided internet-delivered therapy has shown promising results for patients with mild and moderate depressive disorder, but several challenges with the format have been reported. The aim of this qualitative study was to investigate therapists’ experiences providing guided internet-delivered cognitive behavioral therapy for patients with mild and moderate depression.Material and methodsTwelve therapists were interviewed, and the interviews were analyzed using reflexive thematic analysis.Results and conclusionThree themes were created: (1) For the right person, at the right time. This theme is about therapists’ experiences appointing patients to the program. It is challenging to predict which patients will benefit from it, and it is not the right option for all patients. (2) It is not like chatting on Facebook. The second theme was about the experiences with demands on clinics, therapists and patients that must be considered. The internet-delivered treatment should not be viewed as a simple treatment option, and the value of having contact with the patients during treatment was emphasized. (3) It is like a railroad, but without the switches. This theme was about the experiences with how the treatment content was conveyed to the patients, how the therapists expressed concerns with the usability of the program and the reported need for more possibilities in tailoring treatment for each patient.
Evaluating the effects of a classroom-based bicycle education intervention on bicycle activity, self-efficacy, personal safety, knowledge, and mode choice
Authors: Nachman Elizabeth R. , Rodriguez Daniel A. 
Published: July 2023

IntroductionThis study provides an evaluation of the impacts of classroom-based adult bicycle education on bicycling activity, confidence and competency self-perceptions while bicycling, knowledge of the bicycling rules of the road, and mode choice in a sample of residents of the San Francisco Bay Area in the US.MethodsChanges were measured with self-administered surveys completed before and six weeks after the course intervention. Self-reported data were validated using objective data collected using the Ride Report app. We used multivariable regression analyses to examine changes in self-reported data over time.ResultsParticipants reported statistically significant increases in confidence while bicycling in both traffic and car-free areas, feelings of safety while bicycling in car-free areas, and knowledge of the rules of the road. While there were significant changes in the proportion of trips by foot, transit and TNC, there was no change in the count of trips made by bicycle.DiscussionAlthough overall changes in bicycling activity did not change, participants with initial low confidence increased bicycling activity and feelings of safety in traffic, compared to participants overall. Classroom-based bicycle education courses can improve bicycling confidence self-perception and increase knowledge of the bicycling rules of the road.
Pengaruh Konsentrasi Pelarut dan Waktu Maserasi terhadap Hasil Ekstraksi Oleoresin Jahe Merah (Zingiber officinale var. rubrum)
Authors: Baihaqi Baihaqi , Hakim Syahirman , Nuraida Nuraida , Mandasari Mandasari , Mahfuzah Mahfuzah 
Published: July 2023

Oleoresin merupakan campuran resin dan minyak atsiri yang diperoleh dari proses ekstraksi dari berbagai jenis rempah dengan menggunakan pelarut organik. Salah satu rempah yang dapat dibuat menjadi Oleoresin adalah jahe merah. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi pelarut etanol dan waktu maserasi terhadap hasil ekstraksi jahe merah. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) faktorial yang terdiri dari dua faktor yaitu : Faktor I : Pelarut Etanol (E) yang terdiri dari 3 taraf perlakuan yaitu : E1 = 1 : 2, E2 = 1 : 4 dan E3 = 1 : 6. Faktor II : Waktu Maserasi (W) yang terdiri dari 3 taraf perlakuan yaitu : W1 = 6 Jam, W2 = 12 jam dan W3 = 24 jam. Oleoresin yang dihasilkan dilakukan pengamatan meliputi rendemen dan bobot jenis. Hasil penelitian menunjukkan bahwa pelarut etanol berpengaruh sangat nyata terhadap hasil rendemen dan bobot jenis oleoresin jahe merah. Perlakuan terbaik dijumpai pada perlakuan perlarut 1:6 dengan hasil rendemen 8.50 % dan bobot jenis 1.46. Waktu maserasi memberikan pengaruh yang sangat nyata terhadap hasil rendemen oleoresin jahe merah, akan tetapi berpengaruh tidak nyata terhadap bobot jenis ekstrak jahe merah. Perlakuan terbaik dijumpai pada perlakuan 1:6 dengan hasil rendemen 6.68%. Tidak terdapat interaksi yang nyata antara kombinasi perlakuan pelarut etanol dan waktu maserasi terhadap semua pengamatan yang diamati.
PERSEDIAAN BAHAN BAKU TEMBAKAU DENGAN METODE ECONOMIC ORDER QUANTITY (EOQ) PADA PR LOHJINAWI PASURUAN
Authors: Bashori Hasan 
Published: July 2023

Bahan baku merupakan faktor utama di dalam perusahaan untuk menunjang kelancaran proses produksi, baik dalam perusahaan besar maupun perusahaan kecil. Masalah penentuan besarnya permintaan merupakan masalah yang penting dalam perusahaan, karena persediaan mempunyai efek yang langsung terhadap keuntungan perusahaan. Kesalahan dalam menentukan besarnya investasi (modal yang tertanam) dalam persediaan akan menentukan keuntungan perusahaan. Tujuan dari penelitian ini adalah untuk mengetahui jumlah ukuran pemesanan yang ekonomis, mengurangi biaya penyimpanan, dan mengetahui kapan waktu pemesanan atau pembuatan harus dilakukan. Penelitian ini difokuskan pada bahan baku tembakau yang diproduksi oleh P.R LOHJINAWI Pasuruan untuk menjadi rokok. Adapun hasil perhitungan dari pengolahan data yang dilakukan adalah dengan prediksi permintaan untuk periode selanjutnya (Januari 2021) adalah sebesar 96 ball. Dalam menentukan sistem pengendalian persediaan bahan baku, dipilih total biaya persediaan tahunan yang terkecil. Dari sini sistem pengendalian persediaan bahan baku model EOQ merupakan sistem pengendalian persediaan bahan baku yang baik karena memiliki nilai TIC sebesar Rp.80.796,04 yang lebih kecil jika dibandingkan dengan sistem pengendalian persediaan sebelumnya sebesar Rp.118.000,00 yang dipakai oleh perusahaan, dengan frekuensi pemesanan 2 kali dan jarak siklus pemesanan 12 sampai 13 hari. Dengan menggunakan model EOQ, maka perusahaan dapat melakukan penghematan sebesar 31,61 %.
ANALISA VARIASI SUDUT PENGUAT DAN VARIASI BAJA PROFIL HOLLOW PADA PORTABLE JACKSTAND DENGAN METODE SIMULASI
Authors: Santoso Rama Agus , Farid Akhmad , Suwandono Purbo 
Published: July 2023

Jackstand portable trail merupakan sebuah alat bantu khusus mototrail yang berfungsi sebagai pengganti standar tengah. Desain ulang pada jackstand portable menjadi sangat penting untuk mengetahui tingkat keamanan dan kekuatan dalam menahan beban, sehingga perlu dilakukan desain ulang dan diuji melalui simulasi untuk mengetahui faktor keamanannya. (Affairs et al., 2018). Penelitian ini dilakukan dengan menggunakan metode simulasi yang merupakan metode dengan memperagakan sesuatu dalam bentuk tiruan yang mirip keadaan sesungguhnya serta penggambaran suatu system atau proses dengan peragaan berupa model statistic atau pemeran. Variabel bebas dalam penelitian ini yaitu sudut penguat pada jackstand portable yang disimulasikan dengan menggunakan software solidwork pada sudut 40°, 45°, 50°, 55°, 60°, 65°, 70°, 75°, dan 80° dengan variasi material berupa pipa 40x20 mm dan pipa 20x20 mm dengan diberikan beban yang sama yaitu 3000 N. Kemudian dapat diketahui nilai tegangan maksimun (Mpa) dan safety factor (FoS) yang dihasilkan. Dari hasil penelitian diketahui bahwa pada variasi material pipa 40x20 mm diperoleh nilai yang paling optimal pada variasi sudut penguat 60° dengan yield strength/kekuatan bahannya 220,6 Mpa dan tegangan maksimumnya 88,0 Mpa dengan angka safety factor yang tinggi yaitu 2,5. Sedangkan pada variasi material pipa 20x20 mm diperoleh nilai yang paling optimal pada variasi sudut penguat 65° dengan yield strength/kekuatan bahannya 220,6 Mpa dan tegangan maksimumnya 80,8 Mpa dengan angka safety factor yang tinggi yaitu 2,7. Pada sudut 65° inilah yang menghasilkan percobaan simulasi yang paling kuat jika diberi beban dan disudut 65° dari variasi material pipa 20x20 mm juga memperoleh nilai tegangan maksimum paling dibandingkan dengan material pipa 40x20 mm. Selain itu material pipa 20x20 mm memiliki harga yang lebih murah dibandingkan material pipa 40x20 mm sehingga lebih efisien.
EFEKTIVITAS MENGUNYAH BUAH PIR HIJAU (PYRUS COMMUNIS) DAN BUAH PISANG AYAM (MUSA ACUMINATA COLLA) TERHADAP DERAJAT KEASAMAN DAN KAPASITAS BUFFER SALIVA PADA ANAK UMUR 6-12 TAHUN
Authors: Molek Molek , Adriana Shirley , Manalu Roma Ulina 
Published: July 2023

Kesehatan gigi serta mulut menjadi peran dalam kesehatan tubuh yang ikut menentukan keadaan kesehatan secara keseluruhan. Buah pir hijau (Pyrus communis) mengandung serat juga air yang banyak hingga buah ini bisa membersihkan sisa plak makanan pada gigi dengan alami. Selain buah pir, buah pisang ayam (Musa acuminata Colla) juga memiliki manfaat untuk mengurangi pH Saliva. Kandungan Karbohidrat terfermentasi pada buah pisang ayam bisa mengurangi pH saliva karena menaikkan proses bakteri dalam produksi asam. Kebaruan penelitian ini karena meneliti efektivitas mengunyah buah pir hijau dan buah pisang ayam terhadap nilai pH serta ukuran buffer saliva anak. Tujuan penelitian untuk mengetahui efektivitas mengunyah buah pir hijau) dan buah pisang ayam) terhadap nilai pH serta ukuran buffer saliva anak umur 6-12 tahun. Populasi dalam penelitian adalah seluruh murid berumur 6-12 tahun berjumlah 95. Jumlah sampel ialah 32 orang dengan menggunakan rumus Federer. Analisis data univariat serta bivariat memakai uji paired t-test. Hasil Rerata derajat keasaman saliva sebelum mengunyah buah pir hijau adalah 6,57±0,22 dan setelah mencapai 6,85±0,20, sedangkan derajat keasaman saliva sebelum mengunyah buah pisang ayam diperoleh rerata sebesar 6,84±0,18 dan setelah menjadi 6,57±0,19. Rerata kapasitas buffer saliva sebelum mengunyah buah pir hijau adalah 5,49±0,16 dan setelah mencapai 5,94±0,15. Sedangkan kapasitas buffer saliva sebelum mengunyah buah pisang ayam diperoleh rerata sebesar 5,41±0,16, dan setelah menjadi 4,91±0,56. Kesimpulan terdapat perbedaan derajat keasaman saliva dan kapasitas buffer sebelum dan setelah mengunyah buah pir hijau dan buah pisang ayam terhadap derajat keasaman dan kapasitas buffer saliva anak.
PELATIHAN PERBANYAKAN TANAMAN PALA SECARA GENERATIF DI DESA SOATABARU, GALELA BARAT
Authors: Patty Zeth , Dilago Zakarias , Kastanja Ariance Yeane 
Published: July 2023

Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan dan ketrampilan petani pala dalam melakukan perbanyakan tanaman pala secara generatif. Kegiatan berlangsung selama 1 bulan di Desa Soatobaru Kecamatan Galela Barat, Kabupaten Halmahera Utara, dengan melibatkan 30 petani yang aktif membudidayakan tanaman pala. Metode yang digunakan adalah metode penyuluhan dan pelatihan. Hasil kegiatan menunjukkan bahwa terjadi peningkatan pengetahuan dan ketrampilan petani pala dalam hal perbanyakan pala secara generatif, yang ditunjukkan dari beberapa indikator yakni penetuan lokasi pembibitan, syarat pohon induk yang baik, tahapan pemilihan biji pala, ciri biji pala yang baik, ciri pala jantan dan betina, perlakuan pada biji pala, jenis media tanam.
Pattern of Salivary Gland Tumours among Patients Attending Otorhinolaryngology and Maxillofacial Services at Tertiary Hospital in Tanzania, A Cross-Sectional Study
Authors: Massawe Enica Richard , Masago John , Liyombo Edwin 
Published: July 2023

The proportion of neoplasms of the salivary gland in the study population accounted for 10% of all head & neck and 3% of all neoplasms in the body. There is a scarcity of information regarding salivary gland tumours in Tanzania; therefore, this study addresses important issues in prevalence, histological, demographic characteristics, co-morbidities and treatment of salivary gland tumours. This study aimed to determine the pattern of salivary gland tumours among patients attending Otorhinolaryngology and Maxillofacial services at a tertiary hospital. This was a cross-sectional study done on patients diagnosed with salivary gland tumours. A total of 276 patients were recruited. Pre-tested coded questionnaires were used to collect data which were later analysed using SPSS statistical computer software version 20.0. Of the studied 276 participants, 156 (56.5%) were males, and 120 (43.5%) were females. Their age group ranged between 0 to 90 years with a mean age of 49.47 years, SD ±15.7. Most of them, 69 (28.6 %) aged above 60 years, and 31 (26.1 %) were in the age group of 40-49 and 60+ years. Mostly affected were males, 64 (55.1%) and 52 (44.8%) were females, P=0.76. The most commonly affected site was the parotid gland (75%), and the least affected sites were submandibular and sublingual (7.5%). Among 116 patients, malignant and benign types accounted for 76 (66%) and 40 (34%), respectively. Both benign and malignant salivary gland tumours (SGT) had male preponderance. Pleomorphic adenoma was high in males (28.1%) compared to females (25.0%); mucoepidermoid carcinoma was commonly found, accounting for 23.4% in males and 28.9% in females. More males were commonly affected, particularly the 40-49 age group, although the differences were statistically insignificant (p-value= 0.07). In conclusion, the majority of salivary gland tumours were malignant type and mucoepidermoid carcinoma being the most common histological type, while pleomorphic adenoma was the most frequently encountered benign type, and both had male preponderance, mostly seen at the age of 40 years and above. The majority of patients with malignant tumours presented late to the hospital; therefore, there is a need for advocacy for early health-seeking behaviour to the community and early detection of the disease by health personnel in the primary health centres.
Kejadian Infeksi Saluran Pernafasan Akut (ISPA) Pada Balita Di Puskesmas Pusako Kabupaten Siak
Authors: Yulia Riza  
Published: July 2023

Abstrak
Upaya program pemberantasan penyakit (P2) ISPA pada balita yaitu perlu adanya langkah-langkah dengan melaksanakan promosi penanggulangan ISPA, menemukan penderita, melaksanakan tatalaksana standart penderita dengan deteksi dini, pengobatan yang tepat dan segera, serta melaksanakan pengawasan dan penjagaan kesakitan dan kematian karena ISPA. Tujuan penelitian ini untuk mengetahui Kejadian Infeksi Saluran Pernafasan Akut (ISPA) Pada Balita Di Wilayah Kerja Puskesmas Pusako Kabupaten Siak. Metode penelitian ialah Kualitatif dengan desain Rapid Assasement Procedure, wawancara dilakukan dengan teknik purposive sampling serta observasi pelaksanaan pelayanan dan pencatatan pelaporan program P2 ISPA. Hasil penelitian didapatkan bahwa masih belum optimalnya program P2ISPA dikarenakan pemegang program belum mendapatkan pelatihan, dan dikarenakan pandemic covid-19 petugas kesehatan tidak dapat jemput bola untuk melakukan penanganan ISPA pada balita, kurangnya sinergitas dari masyarakat dan TOMA untuk berperan serta dalam penurunan kasus ISPA pada balita di Puskesmas Pusako. Dapat disimpulkan bahwa perlu adanya adanya perencaanan yang dibuat oleh Penanggung Jawab P2 ISPA sehingga target dari ISPA pada balita terjadi penurunan, harus adanya kesinambungan dan kesadaran masyarakat akan pentingnya mengetahui penyakit ISPA pada balita melalui penyuluhan dan sosialisasi yang diberikan oleh pj promkes sehingga kegiatan P2 ISPA dapat berjalan optimal.
Reconstructing the Volume Density Profile of Prestellar Cores with the Anisotropic Inverse Abel Transform Method
Authors: Zhang Yapeng , Liu Zhengdong , An Weiming , Ping Yongli , Zhong Jiayong 
Published: July 2023

Abstract
Most studies of the 3D density structure of prestellar cores have used isotropic evolution models, which are projected into 2D for direct comparison with observation data. In this study, we introduced the anisotropic inverse Abel transform method for reconstructing the 3D volume density profile of prestellar cores. We demonstrated that this approach could accurately preserve information about the realistic 3D structure with numerical simulation. This method has great advantages compared to the shape-assumption methods, particularly in high-density regions. We applied this method to the Herschel 2D column density maps of three prestellar cores, and the results showed good agreement with theoretical models. By changing the direction of the inversion axis of symmetry, we confirmed that the density profiles of prestellar cores exhibit nearly cylindrical symmetry.