bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approximate Bayesian computation for the natural history of breast cancer, with application to data from a Milan cohort study
Authors: Bondi Laura , Bonetti Marco , Grigorova Denitsa , Russo Antonio 
Published: June 2023

SummaryWe explore models for the natural history of breast cancer, where the main events of interest are the start of asymptomatic detectability of the disease (through screening) and the time of symptomatic detection (through symptoms). We develop several parametric specifications based on a cure rate structure, and present the results of the analysis of data collected as part of a motivating study from Milan. Participants in the study were part of a regional breast cancer screening program, and their ten‐year trajectories were obtained from administrative data available from the Italian national health care system. We first present a tractable model for which we develop the likelihood contributions of the observed trajectories and perform maximum likelihood inference on the latent process. Likelihood based inference is not feasible for more flexible models, and we implement approximate Bayesian computation (ABC) for inference. Issues that arise from the use of ABC for model choice and parameter estimation are discussed, including the problem of choosing appropriate summary statistics. The estimated parameters of the underlying disease process allow for the study of the effect of different examination schedules (age range and frequency of screening examinations) on a population of asymptomatic subjects.
Novel Waxy Starch Cryostructured Coatings Applied on Commercial Crackers
Authors: Coria‐Hernández Jonathan , López‐Figueroa Luis Rodrigo , Méndez‐Albores Abraham , Arjona‐Román José Luis , Meléndez‐Pérez Rosalía 
Published: June 2023

AbstractThe food industry is constantly striving to find new ways to preserve the characteristics of its products during storage, so it is important to create new ways to achieve this. A viable alternative is the use of coatings that are compatible with the surface of food and safe for consumption, which restricts the exchange of water vapor between the material and the environment. Coatings from waxy starch cryogels are an alternative little studied and with great potential for use in crackers. The coating prevents the cookies from absorbing approximately 50% less water from the environment when stored under controlled conditions, directly reflecting on their mechanical properties. Likewise, it is verified through the micrographs obtained by Scanning Electron Microscopy that the surface of the crackers is modified with the addition of cryogel. Regarding the analysis by Fourier Transform Infrared‐Attenuated Total Reflection spectroscopy and thermal by Modulated Differential Scanning Calorimetry, it is observed that the coating modified interactions at the molecular level in terms of the vibrations of the main functional groups and their thermal behavior in terms of heat flow, heat capacity, and evaporation enthalpies. It is found that the coating works as an excellent barrier to water vapor after 21 days of storage.
Prospective evaluation of canine partial limb amputation with socket prostheses
Authors: Wendland Theresa M. , Seguin Bernard , Duerr Felix M. 
Published: June 2023

AbstractBackgroundCanine prostheses have been commercially available for many years but are still in early stages of research, development, and clinical application.ObjectiveTo prospectively investigate mid‐term clinical outcomes of partial limb amputation with a socket prosthesis (PLASP) in canine patients via a descriptive prospective clinical case series and to describe a clinical protocol for PLASP.MethodsClient‐owned dogs (n = 12) with distal limb pathology for which total limb amputation was recommended were enrolled. Partial limb amputation was performed and a socket prosthesis was moulded and fitted to the limb. Complications, clinical follow‐up, and objective gait analysis (OGA) were recorded for at least 6 months. An online survey was completed by owners after study completion.ResultsTen dogs with thoracic limb pathology and two with pelvic limb pathology were included. The most common site of amputation was mid‐radius (n = 5). Eleven of 12 dogs demonstrated quadrupedal gait on OGA with mean per cent body weight distribution (%BWD) of 26% on thoracic limb prostheses and a %BWD of 16% for the one pelvic limb prosthesis that OGA data were available for. Complications included prosthesis suspension difficulties (n = 5), pressure sores (4), bursitis (4), postoperative infection (3), prosthesis aversion (2), dermatitis (1), and owner noncompliance (1). Two owners elected to discontinue prosthesis use.ConclusionsPLASP allowed restoration of quadrupedal gait patterns in most patients. Owners reported overall positive satisfaction, though a high complication rate was observed. PLASP should be considered in select cases as an alternative to total limb amputation for dogs with distal limb pathology.
Maximizing the potential for living cell banks to contribute to global conservation priorities
Authors: Mooney Andrew , Ryder Oliver A. , Houck Marlys L. , Staerk Johanna , Conde Dalia A. , Buckley Yvonne M. 
Published: June 2023

AbstractAlthough cryobanking represents a powerful conservation tool, a lack of standardized information on the species represented in global cryobanks, and inconsistent prioritization of species for future sampling, hinder the conservation potential of cryobanking, resulting in missed conservation opportunities. We analyze the representation of amphibian, bird, mammal, and reptile species within the San Diego Zoo Wildlife Alliance Frozen Zoo® living cell collection (as of April 2019) and implement a qualitative framework for the prioritization of species for future sampling. We use global conservation assessment schemes (including the International Union for Conservation of Nature (IUCN) Red List of Threatened Species™, the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES), the Alliance for Zero Extinction, the EDGE of Existence, and Climate Change Vulnerability), and opportunities for sample acquisition from the global zoo and aquarium community, to identify priority species for cryobanking. We show that 965 species, including 5% of all IUCN Red List “Threatened” amphibians, birds, mammals, and reptiles, were represented in the collection and that sampling from within existing zoo and aquarium collections could increase representation to 16.6% (by sampling an additional 707 “Threatened” species). High‐priority species for future cryobanking efforts include the whooping crane (Grus americana), crested ibis (Nipponia nippon), and Siberian crane (Leucogeranus leucogeranus). Each of these species are listed under every conservation assessment scheme and have ex situ populations available for sampling. We also provide species prioritizations based on subsets of these assessment schemes together with sampling opportunities from the global zoo and aquarium community. We highlight the difficulties in obtaining in situ samples, and encourage the formation of a global cryobanking database together with the establishment of new cryobanks in biodiversity‐rich regions.
Economization
Authors: Hallonsten Olof 
Published: June 2023

AbstractCurrent society’s obsession with innovation is tightly connected with the reorientation of politics and public life to economic concerns, and the rise of an enterprise culture that reshapes individuals as economic subjects. These changes have been ongoing since the 1960s and 1970s, and include the elevation of economic priorities to a prime role in policymaking, and a proliferation of the view of the market as the superior form of human organization and human interaction. The chapter chronicles and analyzes this development, with the help of social theory of modernity and late modernity, and organizational sociological conceptualizations of economization and managerialism.
Candidate iO from Homomorphic Encryption Schemes
Authors: Brakerski Zvika , Döttling Nico , Garg Sanjam , Malavolta Giulio 
Published: June 2023

AbstractWe propose a new approach to construct general-purpose indistinguishability obfuscation (iO). Our construction is obtained via a new intermediate primitive that we call split fully homomorphic encryption (split FHE), which we show to be sufficient for constructing iO. Specifically, split FHE is FHE where decryption takes the following two-step syntactic form: (i) a secret decryption step that uses the secret key and produces a hint which is (asymptotically) shorter than the length of the encrypted message, and (ii) a public decryption step that only requires the ciphertext and the previously generated hint (and not the entire secret key) and recovers the encrypted message. In terms of security, the hints for a set of ciphertexts should not allow one to violate semantic security for any other ciphertexts. Next, we show a generic candidate construction of split FHE based on three building blocks: (i) A standard FHE scheme with linear decrypt-and-multiply (which can be instantiated with essentially all LWE-based constructions), (ii) a linearly homomorphic encryption scheme with short decryption hints (such as the Damgård-Jurik encryption scheme, based on the DCR problem), and (iii) a cryptographic hash function (which can be based on a variety of standard assumptions). Our approach is heuristic in the sense that our construction is not provably secure and makes implicit assumptions about the interplay between these underlying primitives. We show evidence that this construction is secure by providing an argument in an appropriately defined oracle model. We view our construction as a big departure from the state-of-the-art constructions, and it is in fact quite simple.
Frobenius pseudo-variety of numerical semigroups with a given multiplicity and ratio
Authors: Moreno-Frías M. A. , Rosales J. C. 
Published: June 2023

AbstractIn this paper, we study the set $$\mathscr {L}(m,r)$$

L
(
m
,
r
)

of all numerical semigroups with multiplicity m and ratio r. In particular, we present some algorithms that compute all the elements of $$ \mathscr {L}(m,r)$$

L
(
m
,
r
)

with a given genus or with a given Frobenius number.
Efficacy of iron-silver bimetallic nanoparticles to enhance radiotherapy
Authors: Afifi Marwa M. , El-Gebaly Reem H. , Abdelrahman Ibrahim Y. , Rageh Monira M. 
Published: June 2023

AbstractRadiotherapy (RT) is one of the primary cancer treatment methods. Radiosensitizers are used to enhance RT and protect healthy tissue. Heavy metals have been studied as radiosensitizers. Thus, iron oxide and iron oxide/silver nanoparticles have been the main subjects of this investigation. A simple honey-based synthesis of iron (IONPs) and iron-silver bimetallic nanoparticles (IO@AgNPs) were prepared followed by characterization with transmission electron microscope (TEM), absorption spectra, vibrating sample magnetometer (VSM), and X-ray diffraction (XRD). Additionally, Ehrlich carcinoma was induced in 30 adult BALB/c mice and divided into 6 groups. Mice of group G1 were not treated with nanoparticles or exposed to irradiation (control group), and group G2 and G3 were treated with IONPs and IO@AgNPs respectively. Mice of group G4 were exposed to a high dose of gamma radiation (HRD) (12 Gy). Groups G5 and G6 were treated with IONPs and IO@AgNPs followed by exposure to a low dose of gamma radiation (LRD) (6 Gy) respectively. The impact of NP on the treatment protocol was evaluated by checking tumor growth, DNA damage, and level of oxidative stress in addition to investigating tumor histopathology. Additional research on the toxicity of this protocol was also evaluated by looking at the liver’s cytotoxicity. When compared to HRD therapy, combination therapy (bimetallic NPs and LRD) significantly increased DNA damage by about 75% while having a stronger efficacy in slowing Ehrlich tumor growth (at the end of treatment protocol) by about 45%. Regarding the biosafety concern, mice treated with combination therapy showed lower alanine aminotransferase (ALT) levels in their liver tissues by about half the value of HRD. IO@AgNPs enhanced the therapeutic effect of low-dose radiation and increased the efficacy of treating Ehrlich tumors with the least amount of harm to normal tissues as compared to high radiation dosage therapy.
Managing Intractable Natural Resource Conflicts: Exploring Possibilities and Conditions for Reframing in a Mine Establishment Conflict in Northern Sweden
Authors: Johansson Andreas 
Published: June 2023

AbstractNatural resource management (NRM) increasingly relies on communicative measures to enable reframing in intractable conflicts. Reframing occurs when disputants change their perceptions of a conflict situation, and/or their preferences for dealing with it. However, the types of reframing possible, and the conditions under which they can occur, remain unclear. Through an inductive and longitudinal analysis of a mine establishment conflict in northern Sweden this paper explores to what extent, how, and under what conditions reframing can occur in intractable NRM conflicts. The findings reveal the difficulty in achieving consensus-oriented reframing. Despite multiple dispute resolution efforts, the disputants’ perceptions and preferences became increasingly polarized. Nonetheless, the results suggest that it is possible to enable reframing to the extent that all disputants can understand and accept each other’s different perceptions and positions, i.e., meta-consensus. Meta-consensus hinges on neutral, inclusive, equal, and deliberative intergroup communication. However, the results show that intergroup communication and reframing are significantly informed by institutional and other contextual factors. For example, when implemented within the formal governance system in the investigated case, intergroup communication lagged in quality and did not contribute to meta-consensus. Moreover, the results show that reframing is strongly influenced by the nature of the disputed issues, actors’ group commitments, and the governance system’s distribution of power to the actors. Based on these findings, it is argued that more efforts should focus on how governance systems can be configurated so that high-quality intergroup communication and meta-consensus can be enabled and inform decision making in intractable NRM conflicts.
The prevalence and incidence of progressive supranuclear palsy and corticobasal syndrome: a systematic review and meta-analysis
Authors: Lyons Shane , Trépel Dominic , Lynch Tim , Walsh Richard , O’Dowd Sean 
Published: June 2023

Abstract
Introduction
Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are progressive neurodegenerative syndromes characterised by Parkinsonism with additional features including cognitive dysfunction, falls, and oculomotor abnormalities. Understanding the epidemiology of these conditions is critical to planning for future service provision.

Methods
We conducted a systematic review of studies reporting incidence and prevalence of CBS and PSP. A search of the PubMed and EMBASE data bases was conducted from their date of inception to 13th July 2021. Meta-analysis of studies sharing similar methodologies was carried out to generate estimated pooled prevalence and incidence.

Results
We found 32 studies meeting our criteria for inclusion. There were 20 studies with data on prevalence and 12 with incidence data of PSP. Prevalence of CBS was reported in eight studies while seven studies reported incidence. Reported estimates of prevalence for PSP ranged from 1.00 (0.9–1.1) to 18 (8–28) per 100,000 while prevalence rates for CBS ranged from 0.83 (0.1–3.0) to 25 (0–59). Incidence rates for PSP and CBS respectively ranged from 0.16 (0.07–0.39) to 2.6 per 100,000 person-years and 0.03 (0–0.18) to 0.8 (0.4–1.3) per 100,000 person-years. A random effects model meta-analysis of studies with similar methodologies yielded a pooled prevalence estimate for PSP of 6.92 (4.33–11.06, I2 = 89%, τ2 = 0.3907) and 3.91 (2.03–7.51, I2 = 72%, τ2 = 0.2573) per 100,000 for CBS.

Conclusion
Studies of the epidemiology of PSP and CBS report highly heterogeneous findings. There is a need for further studies using rigorous phenotyping and the most recent diagnostic criteria to understand the true burden of these conditions.
J. M. Coetzee and the Limits of the Novel
Authors: Bolin John 
Published: June 2023

J. M. Coetzee is widely recognized as one of the most important writers working in English. As a South African (now Australian) novelist composing his best-known works in the latter third of the twentieth century, Coetzee has understandably often been read through the lenses of postcolonial theory and post-war ethics. Yet his reception is entering a new phase bolstered by thousands of pages of new and unpublished empirical evidence housed at the J. M. Coetzee archive at The Harry Ransom Center (University of Texas, Austin). This material provokes a re-reading of Coetzee's project even as it uncovers keys to his process of formal experimentation and compositional evolution up to and including Disgrace (1999). Following Coetzee's false starts, his confrontation of narrative impasses, and his shifting deployment of source materials, J. M. Coetzee and the Limits of the Novel provides a new series of detailed snapshots of one of the world's most celebrated authors.
The Gift of Aging
Authors: Cottrell Houle Marcy , Eckstrom Elizabeth 
Published: June 2023

Award-winning authors Marcy Houle and Elizabeth Eckstrom have teamed up again following the success of their critically acclaimed book The Gift of Caring, winner of the 2016 National Christopher Award. This new book blends frontline science with inspirational stories and insights from wise elders for aging with health, joy, and purpose. The book explains how our bodies and brains age, defining what can be expected with aging and what is unusual. It demonstrates ways we can significantly increase our chances for a positive aging experience into our 80s, 90s and 100s. It offers key strategies for meeting the challenges of aging, informs us of issues of inclusion and equity, and advises on handling legal and financial affairs. The Gift of Aging illustrates how we can make the third act of our lives meaningful and fulfilling, ensuring we as elders can make a difference in our world.
The autopoetics of the self: A ‘demonic’ approach to ontological security studies
Authors: Gehring Lucy 
Published: June 2023

AbstractOntological security studies (OSS) has been established as a significant area of study in critical security studies (CSS) to describe the ways in which social groups sustain and secure a stable sense of self. Although the self is the central figure of OSS, the subfield is yet to engage in a sustained interrogation of subjectivity in a way that questions its colonial foundations. In this article, I return to Jef Huysmans’s seminal understanding of security as a ‘thick signifier’ to analyse the ways in which OSS upholds the colonial activity of ordering, particularly an ordering of the self. By introducing Sylvia Wynter’s account of the emergence of Man-as-human, I question OSS’s conventional understandings of the self as constituted by identity. Analysing the self as a sociogenic being governed by autopoetics uncovers the ways in which understandings of the self that collapse into ‘identity’ serve to uphold coloniality. By redeploying Huysmans’s understanding of ontological security as that which simultaneously orders and guarantees the activity of ordering, I interrogate the ways in which doing OSS has real-world implications for those denied humanness in our colonial present. This analytic, termed a ‘demonic’ approach by Wynter, unlocks radically alternative understandings of being human that can be operationalized in service of collective liberation.
The social consequences of inflation in developing countries
Authors: Ghosh Jayati 
Published: June 2023

AbstractThe title of this article is a riff off a publication of G. C. Harcourt’s 1974 piece, ‘The social consequences of inflation’. He wrote this in a period of the global economy that bears some strong similarities to our own contemporary phase when inflation is suddenly back in the global headlines. There is at least one significant difference: at that time, Harcourt highlighted inflation as the outcome of an excess of total demand in real terms over available supplies of goods and services when the potential workforces and existing stocks of capital goods were fully employed. Current inflationary pressures, by contrast, arise from the combination of specific sectoral supply bottlenecks, rising profit margins in oligopolistic global markets for food and fuel and financial speculation in these markets.
Hierarchical Bayesian Aldrich–McKelvey Scaling
Authors: Bølstad Jørgen 
Published: June 2023

AbstractEstimating the ideological positions of political actors is an important step toward answering a number of substantive questions in political science. Survey scales provide useful data for such estimation, but also present a challenge, as respondents tend to interpret the scales differently. The Aldrich–McKelvey model addresses this challenge, but the existing implementations of the model still have notable shortcomings. Focusing on the Bayesian version of the model (BAM), the analyses in this article demonstrate that the model is prone to overfitting and yields poor results for a considerable share of respondents. The article addresses these shortcomings by developing a hierarchical Bayesian version of the model (HBAM). The new version treats self-placements as data to be included in the likelihood function while also modifying the likelihood to allow for scale flipping. The resulting model outperforms the existing Bayesian version both on real data and in a Monte Carlo study. An R package implementing the models in Stan is provided to facilitate future use.
Read/write factorizable programs
Authors: BHASKAR SIDDHARTH , SIMONSEN JAKOB GRUE 
Published: June 2023

Abstract
In the cons-free programming paradigm, we eschew constructors and program using only destructors. Cons-free programs in a simple first-order language with string data capture exactly P, the class of polynomial-time relations. By varying the underlying language and considering other data types, we can capture several other complexity classes. However, no cons-free programming language captures any functional complexity class for fundamental reasons. In this paper, we cleanly extend the cons-free paradigm to encompass functional complexity classes. Namely, we introduce programs with data that can either only be destructed or only be constructed, which we enforce by a type system on the program variables. We call the resulting programs read/write- (or RW-)factorizable, show that RW-factorizable string programs capture exactly the class FP of polynomial-time functions, and that tail-recursive RW-factorizable programs capture exactly the class FL of logarithmic-space functions. Finally, we state and solve the nontrivial problem of syntactic composition of two RW-factorizable programs.