bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resting-state EEG delta and alpha power predict response to cognitive behavioral therapy in depression: a Canadian biomarker integration network for depression study
Authors: Schwartzmann Benjamin , Quilty Lena C. , Dhami Prabhjot , Uher Rudolf , Allen Timothy A. , Kloiber Stefan , Lam Raymond W. , Frey Benicio N. , Milev Roumen , Müller Daniel J. , Soares Claudio N. , Foster Jane A. , Rotzinger Susan , Kennedy Sidney H. , Farzan Faranak 
Published: May 2023

AbstractCognitive behavioral therapy (CBT) is often recommended as a first-line treatment in depression. However, access to CBT remains limited, and up to 50% of patients do not benefit from this therapy. Identifying biomarkers that can predict which patients will respond to CBT may assist in designing optimal treatment allocation strategies. In a Canadian Biomarker Integration Network for Depression (CAN-BIND) study, forty-one adults with depression were recruited to undergo a 16-week course of CBT with thirty having resting-state electroencephalography (EEG) recorded at baseline and week 2 of therapy. Successful clinical response to CBT was defined as a 50% or greater reduction in Montgomery-Åsberg Depression Rating Scale (MADRS) score from baseline to post-treatment completion. EEG relative power spectral measures were analyzed at baseline, week 2, and as early changes from baseline to week 2. At baseline, lower relative delta (0.5–4 Hz) power was observed in responders. This difference was predictive of successful clinical response to CBT. Furthermore, responders exhibited an early increase in relative delta power and a decrease in relative alpha (8–12 Hz) power compared to non-responders. These changes were also found to be good predictors of response to the therapy. These findings showed the potential utility of resting-state EEG in predicting CBT outcomes. They also further reinforce the promise of an EEG-based clinical decision-making tool to support treatment decisions for each patient.
Surveillance of avian influenza viruses from 2014 to 2018 in South Korea
Authors: Españo Erica , Shim Sang-Mu , Song Eun-Jung , Nam Jeong-Hyun , Jeong Seo-Hee , Padasas Bill Thaddeus , Kim Sang-Hyun , Kim Jeong-Ki 
Published: May 2023

AbstractSurveillance of influenza A viruses (IAVs) among migratory waterfowl is a first step in understanding the ecology, biology, and pathogenicity of IAVs. As part of the nationwide surveillance effort for IAVs in fowl in South Korea, we collected environmental fecal samples in different migratory bird stopover sites in South Korea during the winter seasons within November 2014 through January 2018. We collected a total of 6758 fecal samples, 75 of which were positive for IAV (1.11% positivity). Prevalence of IAVs varied per site and per year. Based on sequencing, the most prevalent hemagglutinin (HA) subtypes were H1, H6, and H5, and the most prevalent neuraminidase (NA) subtypes were N1, N3, and N2. Phylogenetic analyses showed that the genes we isolated clustered with reported isolates collected from other locations along the East Asian-Australasian Flyway. All the H5 and H7 isolates collected in this study were of low pathogenicity. None of the N1 and N2 genes carried amino acid markers of resistance against NA inhibitors. The winter 2016–2017 subset were primarily borne by migratory geese (Anser spp.). These results suggest that majority of the IAVs circulating among migratory wild fowl in South Korea in 2014–2018 were of low pathogenicity.
A model for emergency supply management under extended EDAS method and spherical hesitant fuzzy soft aggregation information
Authors: Ashraf Shahzaib , Sohail Muhammad , Choudhary Razia , Naeem Muhammad , Chambashi Gilbert , Ali Mohamed R. 
Published: May 2023

AbstractDue to the frequent occurrence of numerous emergency events that have significantly damaged society and the economy, the need for emergency decision-making has been manifest recently. It assumes a controllable function when it is critical to limit property and personal catastrophes and lessen their negative consequences on the natural and social course of events. In emergency decision-making problems, the aggregation method is crucial, especially when there are more competing criteria. Based on these factors, we first introduced some basic concepts about SHFSS, and then we introduced some new aggregation operators such as the spherical hesitant fuzzy soft weighted average, spherical hesitant fuzzy soft ordered weighted average, spherical hesitant fuzzy weighted geometric aggregation, spherical hesitant fuzzy soft ordered weighted geometric aggregation, spherical hesitant fuzzy soft hybrid average, and spherical hesitant fuzzy soft hybrid geometric aggregation operator. The characteristics of these operators are also thoroughly covered. Also, an algorithm is developed within the spherical hesitant fuzzy soft environment. Furthermore, we extend our investigation to the Evaluation based on the Distance from Average Solution method in multiple attribute group decision-making with spherical hesitant fuzzy soft averaging operators. And a numerical illustration for “supply of emergency aid in post-flooding the situation” is given to show the accuracy of the mentioned work. Then a comparison between these operators and the EDAS method is also established in order to further highlight the superiority of the established work.
Fungicide-free management of Alternaria leaf blotch and fruit spot on apple indicates Alternaria spp. as secondary colonizer
Authors: Prechsl Ulrich E. , Rizzoli Werner , Marschall Klaus , Jasper Wubs E. R. 
Published: May 2023

AbstractThe fungal genus Alternaria is a pan-global pathogen of > 100 crops, and is associated with the globally expanding Alternaria leaf blotch in apple (Malus x domestica Borkh.) which leads to severe leaf necrosis, premature defoliation, and large economic losses. Up to date, the epidemiology of many Alternaria species is still not resolved as they can be saprophytic, parasitic or shift between both lifestyles and are also classified as primary pathogen able to infect healthy tissue. We argue that Alternaria spp. does not act as primary pathogen, but only as a necrosis-dependent opportunist. We studied the infection biology of Alternaria spp. under controlled conditions and monitored disease prevalence in real orchards and validated our ideas by applying fungicide-free treatments in 3-years field experiments. Alternaria spp. isolates were not able to induce necroses in healthy tissue, but only when prior induced damages existed. Next, leaf-applied fertilizers, without fungicidal effect, reduced Alternaria-associated symptoms (− 72.7%, SE: ± 2.5%) with the same efficacy as fungicides. Finally, low leaf magnesium, sulphur, and manganese concentrations were consistently linked with Alternaria-associated leaf blotch. Fruit spot incidence correlated positively with leaf blotch, was also reduced by fertilizer treatments, and did not expand during storage unlike other fungus-mediated diseases. Our findings suggest that Alternaria spp. may be a consequence of leaf blotch rather than its primary cause, as it appears to colonize the physiologically induced leaf blotch. Taking into account existing observations that Alternaria infection is connected to weakened hosts, the distinction may appear slight, but is of great significance, as we can now (a) explain the mechanism of how different stresses result in colonization with Alternaria spp. and (b) substitute fungicides for a basic leaf fertilizer. Therefore, our findings can result in significant decreases in environmental costs due to reduced fungicide use, especially if the same mechanism applies to other crops.
New insights into the hydrogen evolution reaction using Ni-ZIF8/67-derived electrocatalysts
Authors: Baghban Alireza , Habibzadeh Sajjad , Ashtiani Farzin Zokaee 
Published: May 2023

AbstractOne of the present great challenges is finding nonprecious materials characterized by efficient electrocatalytic behavior in order to substitute the expensive platinum-based materials for the purpose of hydrogen evolution reactions (HERs). In this study, ZIF-67 and ZIF-67 were used as precursors in order to fabricate metallic-doped N-enriched carbon successfully through a simple process of pyrolysis for applying the hydrogen evolution reaction. In addition, nickel was added to these structures in the course of the synthesis procedure. While under high-temperature treatment, Nickel doped ZIF-67 was transformed into metallic NiCo doped N enriched carbon (NiCo/NC), under high-temperature treatments, Ni-doped ZIF-8 changed into metallic NiZn doped N enriched carbon (NiZn/NC). By combining metallic precursors, the following five structures were synthesized: NiCo/NC, Co/NC, NiZn/NC, NiCoZn/NC, as well as CoZn/NC. It is noteworthy that the produced Co/NC shows optimum hydrogen evolution reaction activity along with superior overpotential of 97 mV and the minimum Tafel slope of 60 mV/dec at 10 mA cm. In addition, the superb behavior of hydrogen evolution reaction can be attributable to the numerous active sites, the superior electrical conductivity of carbon, and the firm structure. As a result, the present paper suggests a novel strategy in order to produce nonprecious materials characterized by superb HER efficiency for future scholars.
Investigation of kinetic, isotherm and adsorption efficacy of thorium by orange peel immobilized on calcium alginate
Authors: Khamseh Ali A. Gh. , Ghorbanian Sohrab Ali , Amini Younes , Shadman Mohammad Mahdi 
Published: May 2023

AbstractIn this research work the thorium uptake on immobilized protonated orange peel was studied in a batch system. The effects of effective parameters such as biosorbent dosage, initial metal ion concentration, and contact time on the biosorption of thorium were analyzed. The biosorption capacity of the immobilized orange peel for thorium at optimal conditions of initial pH 3.8, biosorbent dosage 8 g/L, and initial thorium concentration 170 mg/L was found to be 18.65 mg/g. According to the results of contact time, the biosorption process reached equilibrium after around 10 h of contact. Investigation of the kinetics showed that the biosorption of thorium onto immobilized orange peel follows the pseudo-second-order model. The Langmuir and Freundlich isotherms were used to model the experimental equilibrium data. The results showed better agreement by the Langmuir isotherm. The maximum absorption capacity of immobilized protonated orange peel for thorium adsorption was predicted by the Langmuir isotherm at 29.58 mg/g.
The effect of Lavandula Coronopifolia essential oil on the biophysical properties of desensitization and deactivation gating currents in ionotropic receptors
Authors: Qneibi Mohammad , Jaradat Nidal , Al-Maharik Nawaf , Hawash Mohammed , Issa Linda , Suboh Shorooq , Yahya Leen , Khait Adan Abu , Warasneh Amjaad , Bdir Sosana 
Published: May 2023

AbstractThe rising incidence of cancer and the lack of effective therapeutic interventions for many neurological illnesses like Alzheimer's and epilepsy has prompted us to investigate the composition and effects of the Lavandula coronopifolia oil from Palestine on cancer cells and AMPA receptor subunits in the brain due to the vast range of beneficial properties of Lavandula coronopifolia essential oil (EO). GC/MS was used to analyze L. coronopifolia's EO chemistry. EO's cytotoxicity and biophysical effects on AMPA receptors were investigated using MTS and electrophysiological techniques. The GC–MS results revealed that L. coronopifolia EO has a high content of eucalyptol (77.23%), β-pinene (6.93%), and α-pinene (4.95%). The EO showed more significant antiproliferative selectivity activities against HepG2 cancer cell lines than HEK293T cell lines with IC50 values of 58.51 and 133.22 µg/mL, respectively. The EO of L. coronopifolia affected AMPA receptor kinetics (desensitization and deactivation) and preferred homomeric GluA1 and heteromeric GluA1/A2 receptors. These findings indicate the potential therapeutic use of L. coronopifolia EO in the selective treatment of HepG2 cancer cell lines and neurodegenerative diseases.
SARS-CoV-2 omicron variants harbor spike protein mutations responsible for their attenuated fusogenic phenotype
Authors: Park Seung Bum , Khan Mohsin , Chiliveri Sai Chaitanya , Hu Xin , Irvin Parker , Leek Madeleine , Grieshaber Ailis , Hu Zongyi , Jang Eun Sun , Bax Ad , Liang T. Jake 
Published: May 2023

AbstractSince the emergence of the Omicron variants at the end of 2021, they quickly became the dominant variants globally. The Omicron variants may be more easily transmitted compared to the earlier Wuhan and the other variants. In this study, we aimed to elucidate mechanisms of the altered infectivity associated with the Omicron variants. We systemically evaluated mutations located in the S2 sequence of spike and identified mutations that are responsible for altered viral fusion. We demonstrated that mutations near the S1/S2 cleavage site decrease S1/S2 cleavage, resulting in reduced fusogenicity. Mutations in the HR1 and other S2 sequences also affect cell-cell fusion. Based on nuclear magnetic resonance (NMR) studies and in silico modeling, these mutations affect fusogenicity possibly at multiple steps of the viral fusion. Our findings reveal that the Omicron variants have accumulated mutations that contribute to reduced syncytial formation and hence an attenuated pathogenicity.
Polarization bases compensation towards advantages in satellite-based QKD without active feedback
Authors: Chatterjee Sourav , Goswami Kaumudibikash , Chatterjee Rishab , Sinha Urbasi 
Published: May 2023

AbstractLong-distance photonic implementations of quantum key distribution protocols have gained increased interest due to the promise of information-theoretic security against unauthorized eavesdropping. However, a significant challenge in this endeavor is photon-polarization getting affected due to the birefringence of fibers in fiber-based implementations, or variation of reference frames due to satellite movement in long-haul demonstrations. Conventionally, active feedback-based mechanisms are employed for real-time polarization tracking. Here, we propose and demonstrate an alternative approach via a proof-of-principle experiment over an in-lab entanglement-based (BBM92) protocol. In this approach, we perform a quantum state tomography to arrive at optimal measurement bases for any one party resulting in maximal (anti-)correlation in measurement outcomes of both parties. Our polarization-entangled bi-photons have 94% fidelity with a singlet state and a Concurrence of 0.92. By considering a representative 1 ns coincidence window span, we achieve a quantum-bit-error-rate (QBER) of ≈5%, and a key rate of ≈35 Kbps. The performance of our implementation is independent of any local polarization rotation. Finally, using optimization methods we achieve the best trade-off between the key rate, QBER, and balanced key symmetry. Our approach obviates the need for active polarization tracking. It is also applicable to such demonstrations with non-maximally entangled states and prepare-and-measure-based protocols with partially polarized single-photon sources.
Coastal proximity and visits are associated with better health but may not buffer health inequalities
Authors: Geiger Sandra J. , White Mathew P. , Davison Sophie M. C. , Zhang Lei , McMeel Oonagh , Kellett Paula , Fleming Lora E. 
Published: May 2023

AbstractSocieties value the marine environment for its health-promoting potential. In this preregistered study, we used cross-sectional, secondary data from the Seas, Oceans, and Public Health In Europe (SOPHIE) and Australia (SOPHIA) surveys to investigate: (a) relationships of self-reported home coastal proximity and coastal visits with self-reported general health; (b) the potential of both to buffer income-related health inequalities; and (c) the generalizability of these propositions across 15 countries (n = 11,916–14,702). We find broad cross-country generalizability that living nearer to the coast and visiting it more often are associated with better self-reported general health. These results suggest that coastal access may be a viable and generalized route to promote public health across Europe and Australia. However, the relationships are not strongest among individuals with low household incomes, thereby challenging widespread assumptions of equigenesis that access to coastal environments can buffer income-related health inequalities.
The Pathfinder plasmid toolkit for genetically engineering newly isolated bacteria enables the study of Drosophila-colonizing Orbaceae
Authors: Elston Katherine M , Phillips Laila E , Leonard Sean P , Young Eleanor , Holley Jo-anne C , Ahsanullah Tasneem , McReynolds Braydin , Moran Nancy A , Barrick Jeffrey E 
Published: May 2023

Abstract
Toolkits of plasmids and genetic parts streamline the process of assembling DNA constructs and engineering microbes. Many of these kits were designed with specific industrial or laboratory microbes in mind. For researchers interested in non-model microbial systems, it is often unclear which tools and techniques will function in newly isolated strains. To address this challenge, we designed the Pathfinder toolkit for quickly determining the compatibility of a bacterium with different plasmid components. Pathfinder plasmids combine three different broad-host-range origins of replication with multiple antibiotic resistance cassettes and reporters, so that sets of parts can be rapidly screened through multiplex conjugation. We first tested these plasmids in Escherichia coli, a strain of Sodalis praecaptivus that colonizes insects, and a Rosenbergiella isolate from leafhoppers. Then, we used the Pathfinder plasmids to engineer previously unstudied bacteria from the family Orbaceae that were isolated from several fly species. Engineered Orbaceae strains were able to colonize Drosophila melanogaster and could be visualized in fly guts. Orbaceae are common and abundant in the guts of wild-caught flies but have not been included in laboratory studies of how the Drosophila microbiome affects fly health. Thus, this work provides foundational genetic tools for studying microbial ecology and host-associated microbes, including bacteria that are a key constituent of the gut microbiome of a model insect species.
Functional biology and biotechnology of thermophilic viruses
Authors: Doss Ryan K. , Palmer Marike , Mead David A. , Hedlund Brian P. 
Published: May 2023

Abstract
Viruses have developed sophisticated biochemical and genetic mechanisms to manipulate and exploit their hosts. Enzymes derived from viruses have been essential research tools since the first days of molecular biology. However, most viral enzymes that have been commercialized are derived from a small number of cultivated viruses, which is remarkable considering the extraordinary diversity and abundance of viruses revealed by metagenomic analysis. Given the explosion of new enzymatic reagents derived from thermophilic prokaryotes over the past 40 years, those obtained from thermophilic viruses should be equally potent tools. This review discusses the still-limited state of the art regarding the functional biology and biotechnology of thermophilic viruses with a focus on DNA polymerases, ligases, endolysins, and coat proteins. Functional analysis of DNA polymerases and primase-polymerases from phages infecting Thermus, Aquificaceae, and Nitratiruptor has revealed new clades of enzymes with strong proofreading and reverse transcriptase capabilities. Thermophilic RNA ligase 1 homologs have been characterized from Rhodothermus and Thermus phages, with both commercialized for circularization of single-stranded templates. Endolysins from phages infecting Thermus, Meiothermus, and Geobacillus have shown high stability and unusually broad lytic activity against Gram-negative and Gram-positive bacteria, making them targets for commercialization as antimicrobials. Coat proteins from thermophilic viruses infecting Sulfolobales and Thermus strains have been characterized, with diverse potential applications as molecular shuttles. To gauge the scale of untapped resources for these proteins, we also document over 20,000 genes encoded by uncultivated viral genomes from high-temperature environments that encode DNA polymerase, ligase, endolysin, or coat protein domains.
Stalling for Time: Stall, Revision, and Stuttering-Like Disfluencies Reflect Language Factors in the Speech of Young Children
Authors: Garbarino Julianne , Bernstein Ratner Nan 
Published: May 2023

Purpose:
Disfluencies can be classified as stuttering-like disfluencies (SLDs) or typical disfluencies (TDs). Dividing TDs further, stalls (fillers and repetitions) are thought to be prospective, occurring due to planning glitches, and revisions (word and phrase revisions, word fragments) are thought to be retrospective, occurring when a speaker corrects language produced in error. In the first study assessing stalls, revisions, and SLDs in matched groups of children who stutter (CWS) and children who do not stutter (CWNS), we hypothesized that SLDs and stalls would increase with utterance length and grammaticality but not with a child's expressive language level. We expected revisions to be associated with a child having more advanced language but not with utterance length or grammaticality. We hypothesized that SLDs and stalls (thought to be planning-related) would tend to precede grammatical errors.

Method:
We analyzed 15,782 utterances from 32 preschool-age CWS and 32 matched CWNS to assess these predictions.

Results:
Stalls and revisions increased in ungrammatical and longer utterances and with the child's language level. SLDs increased in ungrammatical and longer utterances, but not with overall language level. SLDs and stalls tended to occur before grammatical errors.

Conclusions:
Results suggest that both stalls and revisions are more likely to occur in utterances that are harder to plan (those that are ungrammatical and/or longer) and that, as children's language develops, so do the skills they need to produce both stalls and revisions. We discuss clinical implications of the finding that ungrammatical utterances are more likely to be stuttered.
On‐chip GaAs‐based dual‐band bandpass filters/isolators (DBPFIs)
Authors: Ashley Andrea , Psychogiou Dimitra 
Published: May 2023

AbstractMMIC co‐designed RF components exhibiting the collocated RF signal processing actions of a dual‐band bandpass filter and an RF isolator (DBPFI) are presented. They are based on in‐parallel cascaded bandpass filters/isolators that operate at two different frequencies and two multi‐resonant cells that are added in the RF input and RF output to increase the selectivity and the out‐of‐band isolation of the DBPFI through six added transmission zeros. For proof‐of‐concept demonstration purposes, a DBPFI prototype was designed and manufactured using a commercially available GaAs MMIC process. It exhibited the following RF‐measured characteristics: center frequencies: 8.14 GHz and 10.8 GHz, 3‐dB fractional bandwidth (FBW): 11.1% and 16.4%, |S21|: −3.7 dB and −8.8 dB, isolation >36.6 dB and 16.5 dB, IP1dB: 11.8 dBm and 12.8 dBm, IIP3: 18.2 dBm and 16.5 dBm, and OIP3: 14.2 dBm and 6.7 dBm, respectively, at the lower and the upper band.