bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH MOTIVASI, KOMUNIKASI, KOMITMEN DAN DISIPLIN KERJA TERHADAP KINERJA KARYAWAN DI CV. FISHEROLSHOP BATAM
Authors: Yona Mira - , Audyara Wesa 
Published: December 2022

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh motivasi, komunikasi, komitmen dan disiplin kerja terhadap kinerja karyawan di CV. Fisherolshop Batam. Jenis penelitian ini adalah kuantitatif dengan teknik pengumpulan data menggunakan kuesioner. Dalam penelitian ini populasinya adalah jumlah karyawan CV. Fisherolshop Batam sebanyak 50 responden dan sampel berjumlah 50 responden dengan menggunakan teknik sensus. Hasil analisis dapat diketahui bahwa motivasi tidak berpengaruh positif dan tidak signifikan terhadap kinerja karyawan dengan koefisien regresi sebesar nilai t hitung - 0,850 t table 1,680 dan tingkat signifikan 0,400 0,05, komunikasi tidak berpengaruh positif dan tidak signifikan terhadap kinerja karyawan dengan nilai t hitung 0,311 t table 1,680 dan tingkat signifikan 0,757 0,05, komitmen berpengaruh positif dan signifikan terhadap kinerja karyawan dengan nilai t hitung 2,187 t table 1,680 dan tingkat signifikan 0,034 0,05, disiplin kerja berpengaruh positif dan signifikan terhadap kinerja pegawai dengan nilai t hitung 2,149 t table 1,680 dan tingkat signifikan 0,037 0,05, hasil pengujian F hitung 4,274 F table 2,823 dan nilai signifikan 0,005 0,05 maka hal ini mengindikasikan bahwa antara keempat variabel yang diteliti yaitu motivasi, komunikasi, komitmen dan disiplin kerja berpengaruh secara simultan terhadap kinerja karyawan.
PENGARUH CORPORATE SOCIAL RESPONSIBILITY DAN GOOD CORPORATE GOVERNANCE TERHADAP NILAI PERUSAHAAN
Authors: SA'ADAH LAILATUS , Aninditha Crystal , Soedarman Muhamad 
Published: December 2022

Penelitian ini bertujuan untuk mengkaji pengaruh Corporate Social Responsibility dan Good Corporate Govenance yang terdiri dari kepemilikan manajerial, kepemilikan institusional, dan dewan komisaris independen terhadap nilai perusahaan. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian kuantitaf kausalitas yang diperoleh dari Bursa Efek Indonesia di situs resmi www.idx.co.id. Populasi pada penelitian ini yaitu perusahaan manufaktur kecuali dari sektor semen , logam, tekstil, tembakau, dan alas kaki, yang terdaftar di BEI periode 2018-2020. Sampel yang digunakan dalam penelitian ini ditentukan dengan menggunakan teknik purposive sampling dengan ketentuan sampel yang telah ditetapkan dengan sampel sebanyak 21 perusahaan. Metode analisis data yang digunakan yaitu analisis regresi berganda. Teknik analisis data pada penelitian ini menggunakan analisis Statistik Deskriptif, Uji Asumsi Klasik, Koefesien Determinasi (R2), dan Uji t. Hasil penelitian ini menunjukan bahwa Corporate Social Responsibility berpengaruh terhadap nilai perusahaan, kepemilikan manajerial, kepemilikan institusional dan dewan komisaris independen berpengaruh terhadap nilai perusahaan.
POTENSI KEBANGKRUTAN MENGGUNAKAN MODEL ZAVGREN DAN ALTMAN PADA PERUSAHAAN DI INDONESIA
Authors: E Janrosl Viola Syukrina , Prima Argo Putra , Yuliadi Yuliadi 
Published: December 2022

Perusahaan yang bergerak di bisnis perdagangan komoditas hasil pertambangan dan energi dan juga pabrik perakitan umum. Penelitian ini bertujuan mengetahui dan memberikan bukti empiris terdapat perbedaan potensi kebangkrutan pada perusahaan pertambangan subsektor batu bara yang terdaftar di Indonesian Stock Exchange. Meningkatnya jumlah kegagalan perusahaan sebagaimana disebutkan di atas dan potensinya berdampak pada pekerjaan, kehidupan masyarakat dan ekonomi secara umum berarti bahwa sangat penting untuk dapat memprediksi peristiwa ini di Indonesia sebelum terjadi. Beberapa pemangku kepentingan seperti pemerintah, karyawan, debitur, pemegang saham, dan investor lainnya kehilangan secara substansial dalam kegagalan perusahaan ini. Populasi adalah keseluruhan kelompok orang, kejadian, benda-benda yang menarik peneliti untuk ditelaah. Sampel dalam penelitian ini adalah sub sektor pertambangan tahun 2017-2020 yang terdaftar in indonesia stock exchange. Berdasarkan pengambilan keputusan Uji Wilcoxon jika nilai Asymp. Sig 0,05 maka dapat ditarik kesimpulan ada perbedaan antara hasil prediksi kondisi keuangan perusahaan dengan menggunakan model Zavgren dan Altman
The Urgency Of Sharia Economic Transformation In Facing The Global Economy
Authors: Sani Alfian 
Published: December 2022

This study discusses the urgency of Islamic Economics's transformation in breaking through the global economy. The research method uses qualitative method and descriptive analysis. The research results indicate that to strengthen Islamic Economics, it must have a strategy that goes beyond the global economy and must be based on sharia principles, referring to the Qur'an and Hadith. The transformation that can be felt now with the presence of the Islamic Economy is the establishment of Islamic Financial Institutions and Islamic Banking which supports the development of the real sector. Islamic economics builds the integrity of Muslims who run the economic wheel under Islamic teachings by adhering to the privileges of Islamic economics itself, namely by avoiding all forms of activities that contain elements of usury which have an impact on harm to others. The challenge faced by the sharia economy is that people still need clarification in understanding the essential characteristics that underlie the sharia banking operational system, namely the profit-sharing system.
Vascular endothelial growth factor attenuates neointimal hyperplasia of decellularized small-diameter vascular grafts by modulating the local inflammatory response
Authors: Xie Xinlong , Wu Qiying , Liu Yuhong , Chen Chunyang , Chen Zeguo , Xie Chao , Song Mingzhe , Jiang Zhenlin , Qi Xiaoke , Liu Sixi , Tang Zhenjie , Wu Zhongshi 
Published: December 2022

Small-diameter vascular grafts (diameter &lt;6 mm) are in high demand in clinical practice. Neointimal hyperplasia, a common complication after implantation of small-diameter vascular grafts, is one of the common causes of graft failure. Modulation of local inflammatory responses is a promising strategy to attenuates neointimal hyperplasia. Vascular endothelial growth factor (VEGF) is an angiogenesis stimulator that also induces macrophage polarization and modulates inflammatory responses. In the present study, we evaluated the effect of VEGF on the neointima hyperplasia and local inflammatory responses of decellularized vascular grafts. In the presence of rhVEGF-165 in RAW264.6 macrophage culture, rhVEGF-165 induces RAW264.6 macrophage polarization to M2 phenotype. Decellularized bovine internal mammary arteries were implanted into the subcutaneous and infrarenal abdominal aorta of New Zealand rabbits, with rhVEGF-165 applied locally to the adventitial of the grafts. The vascular grafts were removed en-bloc and submitted to histological and immunofluorescence analyses on days 7 and 28 following implantation. The thickness of the fibrous capsule and neointima was thinner in the VEGF group than that in the control group. In the immunofluorescence analysis, the number of M2 macrophages and the ratio of M2/M1 macrophages in vascular grafts in the VEGF group were higher than those in the control group, and the proinflammatory factor IL-1 was expressed less than in the control group, but the anti-inflammatory factor IL-10 was expressed more. In conclusion, local VEGF administration attenuates neointimal hyperplasia in decellularized small-diameter vascular grafts by inducing macrophage M2 polarization and modulating the inflammatory response.
Incidence of atrial functional tricuspid regurgitation and its correlation with tricuspid valvular deformation in patients with persistent atrial fibrillation
Authors: Yamamoto Yuko , Daimon Masao , Nakanishi Koki , Nakao Tomoko , Hirokawa Megumi , Ishiwata Jumpei , Kiriyama Hiroyuki , Yoshida Yuriko , Iwama Kentaro , Hirose Kazutoshi , Mukai Yasuhiro , Takeda Norifumi , Yatomi Yutaka , Komuro Issei 
Published: December 2022

BackgroundWith the growing prevalence of atrial fibrillation (AF), concomitant atrial functional tricuspid regurgitation (FTR) is increasing. In this study, we aimed to elucidate the incidence of significant atrial FTR and its association with tricuspid valvular (TV) deformation in patients with persistent AF.MethodsWe retrospectively enrolled 344 patients (73.0 ± 9.3 years, 95 female) with persistent AF who underwent 2-dimensional echocardiography. We excluded patients with left-sided heart disease, pulmonary hypertension treated with pulmonary vasodilators, and congenital heart disease. We defined significant TR as having TR ≥ moderate; and tricuspid annulus (TA) diameter, tethering height, and area were measured in all patients.ResultsAmong the study population, 80 (23.3%) patients had significant TR. TA diameter, tethering height, and area were significantly greater in the significant TR group (all p &lt; 0.001). In multivariable analysis, TA diameter was independently associated with significant TR (odds ratio 1.1 per mm, p = 0.03), whereas TV tethering height was not. Receiver operating characteristic curve for significant TR exhibited the best predictive value of TA diameter indexed for body surface area [23 mm/m2; area under the curve (AUC) = 0.87] compared with absolute TA diameter (39 mm; AUC = 0.74) and TA diameter indexed for height (0.22 mm/cm; AUC = 0.80).ConclusionApproximately 25% of patients with persistent AF had significant TR. The BSA-corrected TA diameter was strongly associated with significant TR, which might be helpful for predicting the development of significant TR and considering its therapeutic strategy in patients with persistent AF.
The prevalence of hypertension and its associated risk factors among older adults in Ghana
Authors: Dai Baozhen , Addai-Dansoh Stephen , Nutakor Jonathan Aseye , Osei-Kwakye Jeremiah , Larnyo Ebenezer , Oppong Stephen , Boahemaa Priscilla Yeboah , Arboh Francisca 
Published: December 2022

BackgroundHypertension is a worldwide health issue that primarily affects the elderly in our society. However, in comparison to the developed world, the prevalence of hypertension is higher in Sub-Saharan Africa.ObjectiveThis paper examines the prevalence of hypertension and its associated risk factors among older adults in Ghana.MethodsUsing the World Health Organization’s study on global AGEing and adult health (WHO SAGE) Wave 1 cross-sectional data collected via in-person structured interviews; paper and pencil interviews (PAPI) from ten administrative regions of Ghana using stratified multistage cluster design from respondents aged 50+ grouped by decade, this study analyzed a nationally representative sub-sample of 3,997 respondents employing binary logistic regression. Odds ratios (OR) and 95% confidence intervals (95% CI) were used to estimate risk factors associated with hypertension (blood pressure ≥ 130/80 mm/Hg).ResultsThere was a 53.72% hypertension prevalence rate among older adults. Hypertension prevalence tends to increase with increasing age. The prevalence of hypertension was associated with residency (B = −0.18, OR = 0.84, p &lt; 0.017), with urban residents being more at risk of hypertension than rural residents. The prevalence of hypertension increased with overweight (B = 0.66, OR = 1.94, p &lt; 0.001) and obesity (B = 0.82, OR = 2.28, p &lt; 0.001). The amount of fruit and vegetable intake was insignificant but had an inverse relationship with hypertension prevalence.ConclusionThis study has shown that demographic and lifestyle factors significantly affect and explain the hypertension risk among older adults. Medical factors, such as chronic diseases, were largely insignificant and accounted for less hypertension prevalence. Therefore, when interpreting test findings in clinical practice, such as hypertension, it is essential to consider demographic and lifestyle factors. In addition, health policies and primary interventions that seek to improve the standard of living, lifestyle, and wellbeing of older adults need to be critically considered moving forward to lower hypertension prevalence among older adults in Ghana.
Ultrasound images-based deep learning radiomics nomogram for preoperative prediction of RET rearrangement in papillary thyroid carcinoma
Authors: Yu Jialong , Zhang Yihan , Zheng Jian , Jia Meng , Lu Xiubo 
Published: December 2022

PurposeTo create an ultrasound -based deep learning radiomics nomogram (DLRN) for preoperatively predicting the presence of RET rearrangement among patients with papillary thyroid carcinoma (PTC).MethodsWe retrospectively enrolled 650 patients with PTC. Patients were divided into the RET/PTC rearrangement group (n = 103) and the non-RET/PTC rearrangement group (n = 547). Radiomics features were extracted based on hand-crafted features from the ultrasound images, and deep learning networks were used to extract deep transfer learning features. The least absolute shrinkage and selection operator regression was applied to select the features of nonzero coefficients from radiomics and deep transfer learning features; then, we established the deep learning radiomics signature. DLRN was constructed using a logistic regression algorithm by combining clinical and deep learning radiomics signatures. The prediction performance was evaluated using the receiver operating characteristic curve, calibration curve, and decision curve analysis.ResultsComparing the effectiveness of the models by linking the area under the receiver operating characteristic curve of each model, we found that the area under the curve of DLRN could reach 0.9545 (95% confidence interval: 0.9133–0.9558) in the test cohort and 0.9396 (95% confidence interval: 0.9185–0.9607) in the training cohort, indicating that the model has an excellent performance in predicting RET rearrangement in PTC. The decision curve analysis demonstrated that the combined model was clinically useful.ConclusionThe novel ultrasonic-based DLRN has an important clinical value for predicting RET rearrangement in PTC. It can provide physicians with a preoperative non-invasive primary screening method for RET rearrangement diagnosis, thus facilitating targeted patients with purposeful molecular sequencing to avoid unnecessary medical investment and improve treatment outcomes.
Anti-thyroid antibodies in the relation to TSH levels and family history of thyroid diseases in young Caucasian women
Authors: Kocełak Piotr , Owczarek Aleksander J. , Wikarek Agnieszka , Ogarek Natalia , Oboza Paulina , Sieja Małgorzata , Szyszka Anna , Rozmus-Rogóż Izabela , Puzianowska-Kuźnicka Monika , Olszanecka-Glinianowicz Magdalena , Chudek Jerzy 
Published: December 2022

BackgroundIn young women, hypothyroidism is associated with impaired fertility, increased risk of pregnancy loss, premature delivery, and impaired infant neurodevelopment, justifying the need to recognize the risk of hypothyroidism in women of reproductive age. Thus, this study aimed at assessing the frequency of occurrence of antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb) in young Caucasian women in connection with various confounders.MethodsThe cross-sectional study involved 366 women aged 18-40 years without a diagnosis of thyroid disease. The personal and family medical history was collected, body mass and height were measured and an ultrasound examination of the thyroid gland was performed. Thyrotropin (TSH), free thyroxine, and free triiodothyronine levels, as well as TPOAb and TGAb titers, were determined by ECLIA.ResultsTwo cases of hyperthyroidism (0.5%) and 6 cases (1.6%) of subclinical hypothyroidism were detected. TPOAb was detected in 21 (5.7%) and TGAb in 31 (8.6%) and any of the antibodies in 42 (11.6%) women. Antibodies were more frequent in the subgroup with TSH levels ≥ 2.5 mIU/L than in the subgroup with lower TSH levels (15.5% vs 6.9%, respectively, p&lt;0.05). Any anti-thyroid antibodies were also detected more frequently in the subgroup with TSH levels ≥ 2.5 mIU/L (18.3% vs 10.0%, respectively, p&lt;0.05). Women with the presence of TGAb or seropositive for either TGAb or TPOAb or TPOAb and TGAb antibodies were more likely to have higher TSH levels (OR = 2.48 and OR = 2.02; respectively, p &lt; 0.05 for both). A family history of any thyroid diseases increased the risk of any anti-thyroid antibodies positivity (OR = 1.94; p &lt; 0.05).ConclusionsThe results of our study suggest that TSH ≥ 2.5 mIU/L and a family history of any thyroid diseases justify screening for anti-thyroid antibodies in women of reproductive age, although the occurrence of these antibodies in the majority of cases is not related to thyroid dysfunction.
Relationship between serum NDRG3 and papillary thyroid carcinoma
Authors: Wang Jiahao , Wang Jun , Quan Jinxing , Liu Juxiang , Tian Limin , Dong Changhong 
Published: December 2022

BackgroundIn recent years, papillary thyroid carcinoma is considered to be one of the fastest increaseing cancer. NDRG family member 3 (NDRG3) has been proposed as a molecular marker of tumor, and is expected to be used in clinic.MethodsEnzyme-linked immunosorbent assay was used to detect the serum NDRG3 expression in 81 papillary thyroid carcinoma cases, 75 benign thyroid nodules cases and 77 healthy control cases, respectively. Electrochemiluminescence method was applied to measure the levels of triiodothyronine, tetraiodothyronine, thyrotropin, thyroglobulin antibody and thyroid peroxidase antibody. Immunohistochemical staining was used to detect the expression of NDRG3 in papillary thyroid carcinoma, benign thyroid nodules and normal tissues adjacent to cancer.ResultsThe expression of serum triiodothyronine, tetraiodothyronine, thyrotropin, thyroglobulin antibody and thyroid peroxidase antibody and NDRG3 were significantly different among benign thyroid nodules, papillary thyroid carcinoma cases and healthy control groups (P &lt;0.001). Only the expression of serum NDRG3 was significantly different between benign thyroid nodules and papillary thyroid carcinoma groups (P &lt;0.001). Immunohistochemistry showed that NDRG3 was expressed in all three groups, the lowest in papillary thyroid carcinoma, the second in benign thyroid nodules, and the highest in normal tissues adjacent to cancer. Logistic regression analysis showed that serum NDRG3 was an independent protective factor for papillary thyroid carcinoma (OR =0.964, 95%CI =0.953 to 0.974, P &lt;0.001). The ROC curve of non-papillary thyroid carcinoma diagnosed by serum NDRG3 showed the optimal cut-off value of 481.38 pg/ml, sensitivity of 72.4%, specificity of 90.1%, and the maximum area under the curve (AUC =0.902, 95%CI =0.863 to 0.940, P &lt;0.001). The ROC curve of benign thyroid nodules diagnosed by serum NDRG3 showed the optimal critical value of 459.28 pg/ml, sensitivity of 81.3%, and specificity of 74.1% (AUC =0.863, 95%CI =0.808 to 0.919, P &lt;0.001). The expression level of serum NDRG3 was significantly correlated with extrathyroid extensionand (P =0.007) and lymphatic metastasis of papillary thyroid carcinoma (P =0.019).ConclusionsThe decrease of NDRG3 expression can not only differential diagnosis benign thyroid nodules and papillary thyroid carcinoma, but also serve as a molecular marker for the diagnosis of papillary thyroid carcinoma.
The application of machine learning to imaging in hematological oncology: A scoping review
Authors: Kotsyfakis Stylianos , Iliaki-Giannakoudaki Evangelia , Anagnostopoulos Antonios , Papadokostaki Eleni , Giannakoudakis Konstantinos , Goumenakis Michail , Kotsyfakis Michail 
Published: December 2022

BackgroundHere, we conducted a scoping review to (i) establish which machine learning (ML) methods have been applied to hematological malignancy imaging; (ii) establish how ML is being applied to hematological cancer radiology; and (iii) identify addressable research gaps.MethodsThe review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews guidelines. The inclusion criteria were (i) pediatric and adult patients with suspected or confirmed hematological malignancy undergoing imaging (population); (ii) any study using ML techniques to derive models using radiological images to apply to the clinical management of these patients (concept); and (iii) original research articles conducted in any setting globally (context). Quality Assessment of Diagnostic Accuracy Studies 2 criteria were used to assess diagnostic and segmentation studies, while the Newcastle–Ottawa scale was used to assess the quality of observational studies.ResultsOf 53 eligible studies, 33 applied diverse ML techniques to diagnose hematological malignancies or to differentiate them from other diseases, especially discriminating gliomas from primary central nervous system lymphomas (n=18); 11 applied ML to segmentation tasks, while 9 applied ML to prognostication or predicting therapeutic responses, especially for diffuse large B-cell lymphoma. All studies reported discrimination statistics, but no study calculated calibration statistics. Every diagnostic/segmentation study had a high risk of bias due to their case–control design; many studies failed to provide adequate details of the reference standard; and only a few studies used independent validation.ConclusionTo deliver validated ML-based models to radiologists managing hematological malignancies, future studies should (i) adhere to standardized, high-quality reporting guidelines such as the Checklist for Artificial Intelligence in Medical Imaging; (ii) validate models in independent cohorts; (ii) standardize volume segmentation methods for segmentation tasks; (iv) establish comprehensive prospective studies that include different tumor grades, comparisons with radiologists, optimal imaging modalities, sequences, and planes; (v) include side-by-side comparisons of different methods; and (vi) include low- and middle-income countries in multicentric studies to enhance generalizability and reduce inequity.