bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hot money inflows and bank risk‐taking: Germany from the 1920s to the Great Depression
Authors: Postel‐Vinay Natacha , Collet Stéphanie 
Published: July 2023

AbstractThis paper explores the origins of German banks’ risk‐taking in the years preceding the 1931 crisis. The 1920s were marked by a large and prolonged increase in capital flows into Germany, chiefly from the United States and the United Kingdom. This coincided, at the individual bank level, with a rise in leverage and a fall in liquidity. We examine possible connections between the two phenomena. Our analysis is based on a combination of historiographical work and statistical modelling based on a newly hand‐collected bimonthly dataset on German reporting banks from 1925 to 1935. Bank by bank we examine the effects of foreign inflows on decisions related to leverage, lending, and liquidity. The Dawes Plan of 1924 and the relative absence of a too‐big‐to‐fail (TBTF) environment allow us to mitigate endogeneity concerns. We suggest that while capital inflows did not seem to impact banks’ liquidity decisions, their impact on leverage was non‐negligeable.
Long‐term clinical outcomes and healthcare utilization of sickle cell disease patients with COVID‐19: A 2.5‐year follow‐up study
Authors: Feit Avery , Gordon Moshe , Alamuri Tharun T. , Hou Wei , Mitchell William B. , Manwani Deepa , Duong Tim Q. 
Published: July 2023

AbstractObjectivesThis study investigated whether patients with sickle cell disease (SCD) had elevated risk of worse long‐term clinical outcomes and healthcare utilization 2.5 years post‐SARS‐CoV‐2 infection.MethodsThis study consisted of 178 patients with SCD who tested positive for COVID‐19 between February 1, 2020 and January 30, 2022 in a major academic health system in New York City. The control cohort consisted of two‐to‐one matches of 356 SCD patients without a COVID‐19 positive test. The last follow‐up was July 18, 2022. The primary outcome was mortality. Secondary outcomes were annualized emergency department visits due to pain, pain hospital admission, length of stay due to pain, acute chest syndrome, episodic transfusion, and episodic exchange transfusion.ResultsThere was no significant difference in mortality between SCD patients with and without COVID‐19 (p > .05). There were no significant differences in secondary outcomes between pre‐ and postpandemic (p > .05). There were also no significant differences in these outcomes between SCD patients with and without COVID‐19 (p > .05). SCD care utilization was not significantly associated with COVID‐19 hospitalization status (p > .05).ConclusionsSCD patients with SARS‐CoV‐2 infection incurred no additional risk of worse long‐term outcomes compared to matched controls of SCD patients not infected by SARS‐CoV‐2.
Calibrating epigenetic clocks with training data error
Authors: Mayne Benjamin , Berry Oliver , Jarman Simon 
Published: July 2023

AbstractAnimal age data are valuable for management of wildlife populations. Yet, for most species, there is no practical method for determining the age of unknown individuals. However, epigenetic clocks, a molecular‐based method, are capable of age prediction by sampling specific tissue types and measuring DNA methylation levels at specific loci. Developing an epigenetic clock requires a large number of samples from animals of known ages. For most species, there are no individuals whose exact ages are known, making epigenetic clock calibration inaccurate or impossible. For many epigenetic clocks, calibration samples with inaccurate age estimates introduce a degree of error to epigenetic clock calibration. In this study, we investigated how much error in the training data set of an epigenetic clock can be tolerated before it resulted in an unacceptable increase in error for age prediction. Using four publicly available data sets, we artificially increased the training data age error by iterations of 1% and then tested the model against an independent set of known ages. A small effect size increase (Cohen's d >0.2) was detected when the error in age was higher than 22%. The effect size increased linearly with age error. This threshold was independent of sample size. Downstream applications for age data may have a more important role in deciding how much error can be tolerated for age prediction. If highly precise age estimates are required, then it may be futile to embark on the development of an epigenetic clock when there is no accurately aged calibration population to work with. However, for other problems, such as determining the relative age order of pairs of individuals, a lower‐quality calibration data set may be adequate.
Democratizing accounting technologies: A case of a performance evaluation system for academics
Authors: Mai Kate Thuy , Hoque Zahirul 
Published: July 2023

AbstractThis paper explores how a country's constitutionally imposed democracy in an academic performance evaluation system was designed and practiced. Building upon agonistic democracy and deliberative democracy perspectives, a qualitative inductive case study in a Vietnamese public university involved 52 interviews, direct observations, and the analysis of archival documents. The findings revealed three dimensions of democracy in the university's performance evaluation system, namely, democratic context, democratic discourse, and democratic outcomes. The university enforced democracy in its performance evaluation system for academics in line with the country's constitutional obligation. In such an explicit democratic context, there happened democratic discourse (debating academics’ performance in public forums) and implicit discourse (informal social interactions). The outcome of this democracy at the practice level resulted from temporary consensus supported by shared cultural values within the country's socio‐political context with an understanding that it will change as with any change in the macro or micro contexts. These findings contribute to the literature by providing insights into how individuals pursue democracy in an accounting tool legally built to promote democracy through their multiple voices and collective wisdom. Thus, democratizing accounting technologies and processes, such as an academic performance evaluation system, can effectively promote democracy in multi‐cultural workplaces across the globe.
Global warming and arctic terns: Estimating climate change impacts on the world's longest migration
Authors: Morten Joanne M. , Buchanan Pearse J. , Egevang C. , Glissenaar Isolde A. , Maxwell Sara M. , Parr Nicole , Screen James A. , Vigfúsdóttir Freydís , Vogt‐Vincent Noam S. , Williams Daniel A. , Williams Ned C. , Witt Matthew J. , Hawkes Lucy A. , Thurston William 
Published: July 2023

AbstractClimate change is one of the top three global threats to seabirds, particularly species that visit polar regions. Arctic terns migrate between both polar regions annually and rely on productive marine areas to forage, on sea ice for rest and foraging, and prevailing winds during flight. Here, we report 21st‐century trends in environmental variables affecting arctic terns at key locations along their Atlantic/Indian Ocean migratory flyway during the non‐breeding seasons, identified through tracking data. End‐of‐century climate change projections were derived from Earth System Models and multi‐model means calculated in two Shared Socioeconomic Pathways: ‘middle‐of‐the‐road’ and ‘fossil‐fuelled development’ scenarios. Declines in North Atlantic primary production emerge as a major impact to arctic terns likely to affect their foraging during the 21st century under a ‘fossil‐fuelled development’ scenario. Minimal changes are, however, projected at three other key regions visited by arctic terns (Benguela Upwelling, Subantarctic Indian Ocean and the Southern Ocean). Southern Ocean sea ice extent is likely to decline, but the magnitude of change and potential impacts on tern survival are uncertain. Small changes (<1 m s−1) in winds are projected in both scenarios, but with minimal likely impacts on migration routes and duration. However, Southern Ocean westerlies are likely to strengthen and contract closer to the continent, which may require arctic terns to shift routes or flight strategies. Overall, we find minor effects of climate change on the migration of arctic terns, with the exception of poorer foraging in the North Atlantic. However, given that arctic terns travel over huge spatial scales and live for decades, they integrate minor changes in conditions along their migration routes such that the sum effect may be greater than the parts. Meeting carbon emission targets is vital to slow these end‐of‐century climatic changes and minimise extinction risk for a suite of polar species.
BioDeepTime: A database of biodiversity time series for modern and fossil assemblages
Authors: Smith Jansen , Rillo Marina C. , Kocsis Ádám T. , Dornelas Maria , Fastovich David , Huang Huai‐Hsuan M. , Jonkers Lukas , Kiessling Wolfgang , Li Qijian , Liow Lee Hsiang , Margulis‐Ohnuma Miranda , Meyers Stephen , Na Lin , Penny Amelia M. , Pippenger Kate , Renaudie Johan , Saupe Erin E. , Steinbauer Manuel J. , Sugawara Mauro , Tomašovỳch Adam , Williams John W. , Yasuhara Moriaki , Finnegan Seth , Hull Pincelli M. 
Published: July 2023

AbstractMotivationWe have little understanding of how communities respond to varying magnitudes and rates of environmental perturbations across temporal scales. BioDeepTime harmonizes assemblage time series of presence and abundance data to help facilitate investigations of community dynamics across timescales and the response of communities to natural and anthropogenic stressors. BioDeepTime includes time series of terrestrial and aquatic assemblages of varying spatial and temporal grain and extent from the present‐day to millions of years ago.Main Types of Variables IncludedBioDeepTime currently contains 7,437,847 taxon records from 10,062 assemblage time series, each with a minimum of 10 time steps. Age constraints, sampling method, environment and taxonomic scope are provided for each time series.Spatial Location and GrainThe database includes 8752 unique sampling locations from freshwater, marine and terrestrial ecosystems. Spatial grain represented by individual samples varies from quadrats on the order of several cm2to grid cells of ~100 km2.Time Period and GrainBioDeepTime in aggregate currently spans the last 451 million years, with the 10,062 modern and fossil assemblage time series ranging in extent from years to millions of years. The median extent of modern time series is 18.7 years and for fossil series is 54,872 years. Temporal grain, the time encompassed by individual samples, ranges from days to tens of thousands of years.Major Taxa and Level of MeasurementThe database contains information on 28,777 unique taxa with 4,769,789 records at the species level and another 271,218 records known to the genus level, including time series of benthic and planktonic foraminifera, coccolithophores, diatoms, ostracods, plants (pollen), radiolarians and other invertebrates and vertebrates. There are to date 7012 modern and 3050 fossil time series in BioDeepTime.Software FormatSQLite, Comma‐separated values.
SAME/DIFFERENCE? TOWARD A SAPPHIC/NONBINARY SEXUALITY OF HISTORY
Authors: LANSER SUSAN S. 
Published: July 2023

ABSTRACTWhat is the next step when one has published a strong intervention in a field but later recognizes that one's angle of vision deserves new scrutiny? In this article, which began as a roundtable talk, I return to The Sexuality of History: Modernity and the Sapphic, 1565–1830 (2014) to interrogate its “same‐sex” logic through a nonbinary/trans lens. My book argues that seventeenth‐ and eighteenth‐century representations of the sapphic became a flash point for European cultures grappling with questions of power and governance, desire and duty, mobility and difference in an age of colonialism, racial capitalism, revolution, and reaction. In figuring the sapphic exclusively through notions of sameness, however, The Sexuality of History does not do justice to trans and nonbinary figures both historical and fictional. Is there a place among sapphic subjects for these figures, and, if so, with what implications? I argue here for a both/and approach that requires recoding certain figures as nonbinary while still insisting on their efficacy as signs of the sapphic. This recoding encourages a more nuanced exploration of the cultural work performed by sapphic representations and a more expansive conception of what I have called a sapphic episteme. Such revisionist thinking may be useful at a time of social and theoretical tensions at the intersections of “lesbian” and “trans.”
Safety and efficacy of AK0529 in respiratory syncytial virus‐infected infant patients: A phase 2 proof‐of‐concept trial
Authors: Huang Li‐Min , Schibler Andreas , Huang Yi‐Chuan , Tai Andrew , Chi Hsin , Chieng Chae‐Hee , Wang Jinn‐Li , Goldbart Aviv , Tang Swee‐Ping , Huang Yhu‐Chering , George Shane , Alabaz Derya , Bentur Lea , Su Siew‐Choo , de Bruyne Jessie , Karadag Bulent , Gu Feng , Zou Gang , Toovey Stephen , DeVincenzo John P. , Wu Jim Z. 
Published: July 2023

AbstractBackgroundRespiratory syncytial virus (RSV) infection is a cause of substantial morbidity and mortality in young children. There is currently no effective therapy available.MethodsThis was a Phase 2 study of the oral RSV fusion protein inhibitor AK0529 in infants aged 1–24 months, hospitalized with RSV infection. In Part 1, patients (n = 24) were randomized 2:1 to receive a single dose of AK0529 up to 4 mg/kg or placebo. In Part 2, patients (n = 48) were randomized 2:1 to receive AK0529 at 0.5, 1, or 2 mg/kg bid or placebo for 5 days. Sparse pharmacokinetic samples were assessed using population pharmacokinetics modelling. Safety, tolerability, viral load, and respiratory signs and symptoms were assessed daily during treatment.ResultsNo safety or tolerability signals were detected for AK0529: grade ≥3 treatment‐emergent adverse events occurring in 4.1% of patients in AK0529 and 4.2% in placebo groups, respectively, and none led to death or withdrawal from the study. In Part 2, targeted drug exposure was reached with 2 mg/kg bid. A numerically greater reduction in median viral load with 2 mg/kg bid AK0529 than with placebo at 96 h was observed. A −4.0 (95% CI: −4.51, −2.03) median reduction in Wang Respiratory Score from baseline to 96 h was observed in the 2 mg/kg group compared with −2.0 (95% CI: −3.42, −1.82) in the placebo group.ConclusionsAK0529 was well tolerated in hospitalized RSV‐infected infant patients. Treatment with AK0529 2 mg/kg bid was observed to reduce viral load and Wang Respiratory Score.Clinical Trials RegistrationNCT02654171.
A meta‐analysis of the effect of laparoscopic gastric resection on the surgical site wound infection in patients with advanced gastric cancer
Authors: Han Xue , Kong Defeng , He Xuefeng , Xie Shiyu , Li Chunlin 
Published: July 2023

AbstractBy conducting a meta‐analysis of relevant clinical studies on the treatment of advanced gastric cancer (GC) using laparoscopic and open surgeries, we aimed to evaluate the impact of these two surgical approaches on postoperative surgical site infections (SSIs) in patients with advanced GC. We aimed to provide evidence‐based support for preventing SSIs in postoperative patients with advanced GC. From database establishment until May 2023, we systematically searched PubMed, Cochrane Library, MEDLINE, Embase, China National Knowledge Infrastructure, and Wanfang Data databases for relevant studies comparing laparoscopic and open surgeries for the treatment of advanced GC. Two researchers independently performed the literature screening and data extraction based on predefined inclusion and exclusion criteria. The meta‐analysis was conducted using STATA 17.0. Twenty articles involving 3084 patients met the inclusion criteria, including 1462 patients in the laparoscopic group and 1622 cases in the open surgery group. The meta‐analysis results revealed that the incidence of postoperative SSIs was significantly lower in the laparoscopic group than in the open surgery group (odds ratio = 0.341, 95% confidence interval: 0.219–0.532, p < 0.001). The current evidence indicates that laparoscopic radical gastrectomy can significantly reduce the incidence of postoperative site infections in patients with advanced GC.
Screening of the shared pathogenic genes of ulcerative colitis and colorectal cancer by integrated bioinformatics analysis
Authors: Shi Xu , Yu Jun , Lu Chen , Luo Qian , Xu Caihong , Li Jie , Wang Wei 
Published: July 2023

AbstractUlcerative colitis (UC) is one of the high‐risk pathogenic factors for colorectal cancer (CRC). However, the shared gene and signalling mechanisms between UC and CRC remain unclear. The goal of this study was to delve more into the probable causal relationship between UC and CRC. CRC and UC datasets were downloaded from the Gene Expression Omnibus database. Using R software and Perl, differentially expressed genes (DEGs) in both UC and CRC tissues were re‐annotated and screened. The biological activities and signalling pathways involved in DEGs were investigated using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. The STRING database and Cytoscape software were used to construct the gene interaction network. A total of 384 DEGs were selected for further investigation, and functional analysis revealed that inflammatory and immunological responses were crucial in the development of the two diseases. Moreover, the top 15 key genes involved in the UC and CRC were screened using cytoHubba, including IL1B, CXCL10, CCL20, MMP9, ICAM1, CCL4, CXCR1, MMP3, TLR2, PTGS2, IL1RN, IL6, COL1A2, TIMP1 and CXCL1. The identification of these genes in the present study may provide a novel perspective for the prediction, prevention and personalized medicine of UC and CRC patients.
Successful introduction of sensor‐augmented pump therapy in a patient with diabetes and needle phobia: A case report
Authors: Sugai Keiji , Shikuma Junpei , Hiroike Satoshi , Abe Hironori , Suzuki Ryo 
Published: July 2023

ABSTRACTNeedle phobia is a specific phobia classified as an anxiety disorder in the Diagnostic and Statistical Manual of Mental Disorders‐5, and can be a serious problem for patients requiring insulin injections. However, there have been few reports to date on the management of adults with diabetes and needle phobia. We here report a case of a woman with pancreatic diabetes who developed needle phobia and could no longer perform self‐injections. She started to use a sensor‐augmented pump (SAP), and was able to perform a puncture for the insulin pump and the continuous glucose monitoring sensor by herself. The SAP treatment achieved self‐management, better glycemic control, and high treatment satisfaction quantified using the Diabetes Treatment Satisfaction Questionnaire in this patient. Our case suggests the therapeutic potential of SAP in adults with needle phobia and diabetes requiring insulin therapy.
Worn denture teeth of a full‐arch implant‐supported fixed dental prosthesis: A technique to restore
Authors: Goodrick Adam M. , Nadjmi Sassan 
Published: July 2023

AbstractWorn denture teeth continue to be a significant complication with implant‐supported prostheses. This article discusses a case report that used an intraoral scanning system to restore an existing maxillary implant‐supported prosthesis with significant posterior occlusal wear. IPS e.max (Ivoclar Vivadent, Schaan, Liechtenstein) restorations were fabricated and cemented to the prepared posterior denture teeth to re‐establish the occlusal vertical dimension and to help prevent further wear of the occlusal surfaces.
Bacterial infection‐related glomerulonephritis in patients with diabetes
Authors: John Elenjickal Elias , Roy Sanjeet , Eapen Jeethu Joseph , Karuppusami Reka , Jose Nisha , Mani Selvin Sundar Raj , Johny Joseph , Alam Rizwan , Yusuf Sabina , Thomas Athul , Valson Anna T. , David Vinoi George , Varughese Santosh , Alexander Suceena 
Published: July 2023

AbstractAimDiabetic patients are prone to infections, thus making them a unique cohort at risk of developing bacterial infection‐related glomerulonephritis (IRGN).MethodsIn total, 1693 adult diabetic patients underwent kidney biopsy between 2005 and 2021 at our tertiary care hospital in South India. Of these, 121 consecutive cases which met criteria of bacterial IRGN were included in this study.ResultsThe mean age of the cohort was 53.1 ± 10.1 years and 83/121 (68.5%) were males. Majority (98.3%) had type 2 diabetes for a median duration of 6 (IQR, 2–12) years. The most common sites of infection were skin (47/121, 38.8%) and urinary tract (15/121, 12.4%). Fifty percent (58/121) of patients had underlying advanced diabetic kidney disease (DKD). Isolated C3 deposits (without immunoglobulin) occurred in 66/121 (54.5%) patients predominantly in advanced DKD patients. IgA‐dominant glomerulonephritis occurred in only 9/121 (7.4%) patients. Short‐course oral steroid was given to 86/121 (71.1%) patients. Steroid related dysglycemia and immunosuppression related infections occurred in 9/61 (14.8%) and 16/61 (26.2%) patients respectively. Of the 90 patients with follow up details >3 months, 46 (51.1%) progressed to kidney failure over a median period of 0.5 (IQR, 0–7.2) months. Patients diagnosed in the latter half of our study period (2013–2021) were older, less commonly presented with fever, had more pronounced hypocomplementemia and severe renal histology predominantly with a ‘starry sky’ immunofluorescence pattern.ConclusionSuperimposed bacterial IRGN on underlying DKD is associated with poor renal outcomes. Use of short course steroid was associated with significant toxicity.
Developmental diet, life stage and thermal acclimation affect thermal tolerance of the fall armyworm, Spodoptera frugiperda
Authors: Phungula Siphephelo M. , Krüger Kerstin , Nofemela Robert S. , Weldon Christopher W. 
Published: July 2023

AbstractInsect thermal tolerance affects survival and distribution of species but can vary within and between individuals due to the environmental conditions they experience. The fall armyworm (FAW), Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae), recently invaded Africa and its local hotspots are associated with weather and crop phenology. We investigated the effects of larval diet (maize plants, wheat plants or chickpea‐based artificial diet), life stages and acclimation temperature on thermal tolerance traits of FAW to explore how these variables might contribute to its presence in the field. First and sixth instar larvae and adults reared on each diet at 25°C were acclimated for 24 h at 20, 25 or 30°C. We then recorded the critical thermal minimum (CTmin) and critical thermal maximum (CTmax) of individuals. Sixth instars had the highest CTmin but the effects of acclimation and diet on this trait depended on the life stage being tested. CTmin of first instars increased with acclimation temperature when fed on an artificial diet, but sixth instars and adults were not affected by acclimation or larval diet. CTmax was lowest among adults but acclimation and diet again had effects that differed between life stages. CTmax of first instars and adults increased with acclimation temperature but not in sixth instars. Sixth instars and adults reared on the artificial diet had the highest CTmax but diet had no effect on first instar CTmax. Our results show the complexity of thermal tolerance across FAW life stages and suggest the need to consider local temperature variation and available dietary resources when predicting their potential distribution.