bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic contrast‐enhanced computed tomography in dogs with nasal tumors
Authors: Mortier Jeremy R. , Maddox Thomas W. , Blackwood Laura , La Fontaine Matthew D. , Busoni Valeria 
Published: April 2023

AbstractBackgroundTreatment of nasal tumors in dogs is associated with high morbidity and reliable prognostic factors are lacking. Dynamic contrast‐enhanced computed tomography (DCECT) can be used to assess tumor perfusion.ObjectivesTo assess perfusion parameters of nasal tumors (correlating with tumor type) before and during radiotherapy (RT) and find potential correlation with survival.AnimalsTwenty‐four client‐owned dogs with nasal tumors, including 16 epithelial tumors and 8 sarcomas.MethodsProspective cross‐sectional study. All dogs had baseline DCECT to assess fractional vascular volume (BV), blood flow (BF), and transit time (TT). Thirteen dogs had repeat DCECT after 12 Gy of megavoltage RT. Survival times were calculated.ResultsMedian BV was 17.83 mL/100 g (range, 3.63‐66.02), median BF was 122.63 mL/100 g/minute (range, 23.65‐279.99), and median TT was 8.91 seconds (range, 4.57‐14.23). Sarcomas had a significantly lower BF than adenocarcinomas (P = .002), carcinomas (P = .01), and other carcinomas (P = .001), and significantly lower BV than adenocarcinomas (P = .03) and other carcinomas (P = .004). Significant associations were found between epithelial tumors and sarcoma for change in tumor volume (P = .01), width (P = .004), and length (P = .02) in that epithelial tumors decreased in volume whereas sarcomas increased in volume. Perfusion parameters were not correlated with survival.Conclusions and Clinical ImportanceNasal sarcomas have lower BV and BF than nasal carcinomas, and sarcomas have a lower size reduction than carcinomas early on during RT. Baseline results and changes in perfusion parameters may not be correlated with survival.
Coastal mesozooplankton respond to decadal environmental changes via community restructuring
Authors: Mazzocchi Maria Grazia , Di Capua Iole , Kokoszka Florian , Margiotta Francesca , d'Alcalà Maurizio Ribera , Sarno Diana , Zingone Adriana , Licandro Priscilla 
Published: April 2023

AbstractLong‐term ecological research has revealed the impact of climate on marine ecosystems at multiple time scales. Changes in the pelagic system have been detected at the LTER‐MC site in the Gulf of Naples (Tyrrhenian Sea, western Mediterranean) since 1984. Here we analyzed the time series to determine whether zooplankton had significantly changed over the three decades 1984–2015. In addition to the seasonal cycle as the main mode of temporal variability, we observed long‐term trends in the functional groups and species. Copepods, the most abundant group, declined over the years owing to a decrease in the abundance of Acartia clausi, Centropages typicus, the Paracalanus parvus complex, and Oithona spp. Increasing trends were observed for strict carnivores (chaetognaths) and typical filter feeders (cladocerans, appendicularians, and thaliaceans); the latter may be linked to a higher density of <5 μm phytoplankton. Two main temporal shifts were detected: (i) in 1985–87, similarly to the regime shifts registered in other basins of the Northern Hemisphere, and (ii) after 2011, likely related to local atmospheric forcing. The disappearance or decrease in some neritic copepods and the increased abundance of typical offshore species seem to reflect the enhanced influence of the open Tyrrhenian waters at the sampling site. Despite these changes, no significant trends were detected in the total zooplankton abundance and overall composition, which indicates restructuring within the whole community. These results underline the need to examine the entire zooplankton diversity spectrum and improve our knowledge of their ecological traits to detect and interpret long‐term variability.
Newman and the Religion of the Future
Authors: Fisher Anthony 
Published: April 2023

AbstractAlthough underappreciated in his own day, Catholic convert John Henry Newman was remarkably prophetic about the challenges that lay ahead for the Catholic faith. In his 1873 sermon titled, ‘The Infidelity of the Future’, Newman warned of a time when the Church would face not only the cold indifference of agnosticism but also the targeted hostility of those opposed to both God and religion. Yet Newman was not without hope or wisdom for the future Church. This essay examines Newman's insistence upon the need to cultivate an ‘ecclesiastical spirit’ and an ‘intelligent faith’. It specifically explores how Catholic institutions of higher education can respond to Newman's call and assist in bringing about a renewal in the evangelical mission of the Church, providing a much-needed alternative to the wisdom of the world.
Role of stimulator of interferon genes (STING) in the enteric nervous system in health and disease
Authors: Balasubramaniam Arun , Srinivasan Shanthi 
Published: April 2023

AbstractStimulator of Interferon Genes (STING) is a crucial protein that controls the immune system's reaction to bacterial and viral infections. As a pattern‐recognition receptor, STING is found in immune cells as well as in neurons and glia in the enteric nervous system (ENS). Recent studies have linked STING to the pathogenesis of several neurological disorders like multiple sclerosis (MS), Alzheimer's disease (AD), and gastrointestinal disorders, including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), which are characterized by chronic inflammation and dysregulation of the enteric nervous system (ENS) in the digestive tract. STING plays a crucial role in the pathway that induces the production of interferon in response to viral infection in the central nervous system (CNS). A new study by Dharshika et al. in the current issue of Neurogastroenterology and Motility has demonstrated distinct roles for STING in enteric neurons and glia, namely activation of STING leads to IFN‐β production in enteric neurons but not in glia and reducing STING activation in enteric glia does not modulate the severity of Dextran sulfate sodium (DSS) colitis or subsequent loss of enteric neurons. Rather, the role of STING in enteric glia is related to enhancing autophagy. STING can influence gastrointestinal motility and barrier function and therefore be involved in the pathophysiology of IBS and IBD. This mini review highlights the current knowledge of STING in the pathophysiology of CNS and gastrointestinal diseases as well as these newly uncovered roles STING in enteric neurons and glia.
Hereditary dentin defects with systemic diseases
Authors: Su Tongyu , Zhu Yulong , Wang Xiangpu , Zhu Qinglin , Duan Xiaohong 
Published: April 2023

AbstractObjectiveThis review aimed to summarize recent progress on syndromic dentin defects, promoting a better understanding of systemic diseases with dentin malformations, the molecules involved, and related mechanisms.Subjects and MethodsReferences on genetic diseases with dentin malformations were obtained from various sources, including PubMed, OMIM, NCBI, and other websites. The clinical phenotypes and genetic backgrounds of these diseases were then summarized, analyzed, and compared.ResultsOver 10 systemic diseases, including osteogenesis imperfecta, hypophosphatemic rickets, vitamin D‐dependent rickets, familial tumoral calcinosis, Ehlers‐Danlos syndrome, Schimke immuno‐osseous dysplasia, hypophosphatasia, Elsahy‐Waters syndrome, Singleton‐Merten syndrome, odontochondrodysplasia, and microcephalic osteodysplastic primordial dwarfism type II were examined. Most of these are bone disorders, and their pathogenic genes may regulate both dentin and bone development, involving extracellular matrix, cell differentiation, and metabolism of calcium, phosphorus, and vitamin D. The phenotypes of these syndromic dentin defects various with the involved genes, part of them are similar to dentinogenesis imperfecta or dentin dysplasia, while others only present one or two types of dentin abnormalities such as discoloration, irregular enlarged or obliterated pulp and canal, or root malformation.ConclusionSome specific dentin defects associated with systemic diseases may serve as important phenotypes for dentists to diagnose. Furthermore, mechanistic studies on syndromic dentin defects may provide valuable insights into isolated dentin defects and general dentin development or mineralization.
Land scarcity and land access in a hazard‐prone island: Sagar, Indian Sundarbans
Authors: Mallik Chinmoyee , Bandyopadhyay Sunando , Bandopadhyay Sumana 
Published: April 2023

The analytical inseparability of natural environment and society is reiterated by the findings of this study which contributes to a genre of studies that centre‐stages the socio‐ecological system. This study seeks to understand the interplay of state‐related and other modes of securing property rights in the context of pervasive coastal hazards through a case study from the Indian Sundarbans region (Sagar Island in West Bengal). This paper also contributes to research pertaining to slow‐onset disasters and attempts to examine emerging dimensions of land scarcity as well as diverse modes of access to land in the context of progressive ecological vulnerability. The analysis highlights the varying shades of declining land access and investigates how existing land policies and disaster management mechanisms remain far from extending security to communities experiencing environmental crisis. The paper thereby examines how community and state agencies adopting means to allocate property may in fact refute legality and perpetuate informality.
Resiliency through partnerships: Prioritizing STEM workforce pathways amid macro challenges
Authors: Mathieson Danny , Cotrupi Catherine , Schilling Malle , Grohs Jake 
Published: April 2023

AbstractMulti‐institutional educational partnerships are a promising approach to developing the skilled technical workforce. Inexorably, the ability to maintain such partnership networks that support skilled technical workforce education was disrupted by COVID‐19. The purpose of this study is to explore Southwest Virginia's science, technology, engineering, and mathematics (STEM)‐focused multi‐institutional partnership networks, to inventory the disruptive impacts of COVID‐19, and to identify how partnership stakeholders navigated these challenges to prepare students for the skilled technical workforce. This work presents a single‐case study design, highlighting the evolving landscape of STEM workforce education partnership networks in Southwest Virginia throughout the pandemic. The team conducted interviews with 19 regional stakeholders focused on the participants' role throughout the pandemic, barriers to STEM workforce education presented by public health and economic factors, and innovative strategies to sustain and expand partnership networks through COVID‐19. Two key themes emerged from this study: successful partners maintained network connections through adaptive interactions and actors within the network served as brokers to leverage their connections and expand partnerships in the face of adversity. By taking a contextual view of the role of partnership networks in creating equitable STEM workforce pathways during COVID‐19, we develop rich insights into partnership formation, collaboration, resource allocation, and programming amidst challenges to their success.
TARGET OF EAT3 (TOE3) specifically regulates fruit spine initiation in cucumber (Cucumis sativus L.)
Authors: Guo Yalu , Zhao Hongjiao , Wang Yikui , Zhang Tian , Wang Zheng , Chen Xi , Zhang Xingguang , Li Zheng , Shen Junjun 
Published: April 2023

SUMMARYThe presence or absence of spines is an important economic trait of cucumber fruit. Spines are believed to be a type of specialized trichome on the fruit surface, and all the identified cucumber trichome‐less mutants lack fruit spines. However, genes that specifically regulate fruit spine initiation remain to be identified. Here, we found that knocking out cucumber TARGET OF EAT3 homolog (CsTOE3), belonging to the APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) family, affected flower development and, more interestingly, inhibited cucumber fruit spine initiation. On analyzing expression patterns by quantitative reverse transcriptase‐polymerase chain reaction and in situ hybridization assay, CsTOE3 was found to be highly expressed in male and female flowers, and its mRNA accumulated in the tips of sepal and petal primordia and in the cells of fruit spines and peels. Biochemical analyses indicated that CsTOE3 directly interacts with GLABRA1 (CsGL1) and TRANSPARENT TESTA GLABRA1 (CsTTG1), which are positive regulators of trichome formation. In addition, RNA‐seq showed that the transcription levels of eight ERFs were significantly upregulated in CsTOE3 knockout lines. Phytohormone content analysis also revealed a significant increase in the amount of ethylene released by CsTOE3 knockout line, and treatment with the ethylene synthesis inhibitor aminoethoxyvinyl‐glycine partly restored the spineless phenotype. Our results suggest that CsTOE3 specifically regulates fruit spine initiation but does not affect the formation of trichomes on other organs in cucumber. Our findings may have a far‐reaching significance for cucumber germplasm improvement and quality breeding using fruit spines as the target trait.
A retrospective study of the range of cutaneous clinical and histological features of erythema multiforme in five ferrets (Mustela putorius furo)
Authors: Hess Erica , Trainor Karen , Schick Anthea , Mount Rebecca , Garner Michael , Loeffler Diana 
Published: April 2023

AbstractBackgroundErythema multiforme (EM) is an uncommon cutaneous reaction pattern characterised by panepidermal keratinocyte apoptosis with lymphocytic satellitosis, and is reported in domestic animal species, livestock and rarely ferrets.Hypothesis/ObjectivesThe aim of this study was to analyse the spectrum of cutaneous clinical and histological features in ferrets with EM and to evaluate history and treatment outcomes.AnimalsFive client‐owned ferrets with biopsy‐confirmed EM.Materials and MethodsRetrospective review of electronic medical records and histopathological reports from 2002 to 2021. Tissue blocks, haematoxylin and eosin re‐cuts, and unstained slides were collected to review EM lesions and evaluate for infectious agents with special stains. Immunohistochemical staining was performed to assess cases for viral pathogens.ResultsPanepidermal cytotoxic dermatitis consistent with EM was identified in all cases and involved haired skin in four of five and mucous membranes in one of five ferrets. Skin lesions included variably pruritic alopecia, erythema, scaling, crusts and erosions/ulcerations. Histological features included primarily parakeratotic hyperkeratosis, panepidermal keratinocyte apoptosis, lymphocytic satellitosis and interface dermatitis. Superficial colonisation by bacteria, yeasts or by both was a common finding. Four of five ferrets had concurrent adrenal disease, one of which had resolution of skin lesions with deslorelin acetate treatment.Conclusions and Clinical RelevanceAwareness of the distinct clinical and histological features is key to the diagnosis of EM in ferrets. Clinical resolution was observed with gonadotropin‐releasing hormone agonists in two cases, suggesting that adrenal disease should be ruled out as a potential trigger of EM in ferrets.
Unilateral invasive intraocular melanoma with choroidal and optic nerve involvement resulting in bilateral vision loss in a Labrador Retriever
Authors: Opgenorth Taylor A. , Gibson Ryan M. B. , Mamaliger Nataly , Marquardt Taya M. , Beasley Michaela J. , Baughman Brittany , Galle Laurence E. , Telle Mary Rebecca 
Published: April 2023

AbstractA 10‐year‐old male castrated Labrador Retriever cross was referred for evaluation of acute vision loss. Ophthalmic examination revealed mild left sided exophthalmos, bilateral resting mydriasis, an absent direct and reduced consensual PLR in the left eye and reduced direct and absent consensual PLR in the right eye. Examination of the cornea and anterior segment with slit lamp biomicroscopy was unremarkable. Indirect fundoscopy revealed a left optic nerve head obscured by a darkly pigmented lesion. Fundic examination in the right eye was unremarkable. Magnetic resonance imaging revealed a smoothly marginated, lobulated cone to irregularly shaped, strongly T1 hyperintense, T2 and T2 fluid‐attenuated inversion recovery hypointense, strongly contrast enhancing mass closely associated with the entire left optic nerve, extending across the optic chiasm and into the right optic nerve ventrally. Full clinical staging revealed no evidence of metastasis. Exenteration of the left eye was performed. Histopathology revealed an unencapsulated, poorly demarcated, multilobulated and infiltrative pigmented mass that was effacing the posterior choroid and optic nerve. The mass was composed of a moderately pleomorphic population of heavily pigmented polygonal cells arranged in sheets and clusters, displaying moderate anisocytosis and anisokaryosis. The population of cells contained moderate amounts of abundant brown‐black granular pigment consistent with melanin within the cytoplasm. Mitotic figures averaged approximately three per ten 400× fields (2.37 mm2). This is the first report of a melanocytic tumor invading along the optic nerve and tract to result in contralateral vision loss.
Skin wound healing as a mirror to cardiac wound healing
Authors: Lindsey Merry L. , Becirovic‐Agic Mediha 
Published: April 2023

AbstractWound healing is a general response of the body to injury. All organs share in common three response elements to wound healing: inflammation to prevent infection and stimulate the removal of dead cells, active anti‐inflammatory signalling to turn off the inflammatory response, and a repair phase characterized by extracellular matrix scar formation. The extent of scar formed depends on the ability of endogenous cells that populate each organ to regenerate. The skin has keratinocytes that have regenerative capacity, and in general, wounds are fully re‐epithelialized. Heart, in contrast, has cardiac myocytes that have little to no regenerative capacity, and necrotic myocytes are entirely replaced by scars. Despite differences in tissue regeneration, the skin and heart share many wound‐healing properties that can be exploited to predict the cardiac response to pathology. We summarize in this review article our current understanding of how the response of the skin to a wounding event can inform us about the ability of the myocardium to respond to a myocardial infarction.
Suicide in young people: screening, risk assessment, and intervention
Authors: Hughes Jennifer L , Horowitz Lisa M , Ackerman John P , Adrian Molly C , Campo John V , Bridge Jeffrey A 
Published: April 2023

Abstract
Suicide is the fourth leading cause of death among young people worldwide and the third leading cause of death among those in the US. This review outlines the epidemiology of suicide and suicidal behavior in young people. It discusses intersectionality as an emerging framework to guide research on prevention of suicide in young people and highlights several clinical and community settings that are prime targets for implementation of effective treatment programs and interventions aimed at rapidly reducing the suicide rate in young people. It provides an overview of current approaches to screening and assessment of suicide risk in young people and the commonly used screening tools and assessment measures. It discusses universal, selective, and indicated evidence based suicide focused interventions and highlights components of psychosocial interventions with the strongest evidence for reducing risk. Finally, the review discusses suicide prevention strategies in community settings and considers future research directions and questions challenging the field.
Higher burden of cardiometabolic and socioeconomic risk factors in women with type 2 diabetes: an analysis of the Glycemic Reduction Approaches in Diabetes (GRADE) baseline cohort
Authors: Gulanski Barbara I , Butera Nicole M , Krause-Steinrauf Heidi , Lichtman Judith H , Harindhanavudhi Tasma , Green Jennifer B , Suratt Colleen E , AbouAssi Hiba , Desouza Cyrus , Ahmann Andrew J , Wexler Deborah J , Aroda Vanita R 
Published: April 2023

IntroductionType 2 diabetes mellitus (T2DM) is a powerful risk factor for cardiovascular disease (CVD), conferring a greater relative risk in women than men. We sought to examine sex differences in cardiometabolic risk factors and management in the contemporary cohort represented by the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).Research design and methodsGRADE enrolled 5047 participants (1837 women, 3210 men) with T2DM on metformin monotherapy at baseline. The current report is a cross-sectional analysis of baseline data collected July 2013 to August 2017.ResultsCompared with men, women had a higher mean body mass index (BMI), greater prevalence of severe obesity (BMI≥40 kg/m2), higher mean LDL cholesterol, greater prevalence of low HDL cholesterol, and were less likely to receive statin treatment and achieve target LDL, with a generally greater prevalence of these risk factors in younger women. Women with hypertension were equally likely to achieve blood pressure targets as men; however, women were less likely to receive ACE inhibitors or angiotensin receptor blockers. Women were more likely to be divorced, separated or widowed, and had fewer years of education and lower incomes.ConclusionsThis contemporary cohort demonstrates that women with T2DM continue to have a greater burden of cardiometabolic and socioeconomic risk factors than men, particularly younger women. Attention to these persisting disparities is needed to reduce the burden of CVD in women.Trial registration numberClinicalTrials.gov (NCT01794143)