bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intelligent computing for WPT–MEC-aided multi-source data stream
Authors: Zheng Xiangdong , Zhu Fusheng , Xia Junjuan , Gao Chongzhi , Cui Tao , Lai Shiwei 
Published: May 2023

AbstractDue to its low latency and energy consumption, edge computing technology is essential in processing multi-source data streams from intelligent devices. This article investigates a mobile edge computing network aided by wireless power transfer (WPT) for multi-source data streams, where the wireless channel parameters and the characteristic of the data stream are varied. Moreover, we consider a practical communication scenario, where the devices with limited battery capacity cannot support the executing and transmitting of computational data streams under a given latency. Thus, WPT technology is adopted for this considered network to enable the devices to harvest energy from the power beacon. In further, by considering the device’s energy consumption and latency constraints, we propose an optimization problem under energy constraints. To solve this problem, we design a customized particle swarm optimization-based algorithm, which aims at minimizing the latency of the device processing computational data stream by jointly optimizing the charging and offloading strategies. Furthermore, simulation results illustrate that the proposed method outperforms other benchmark schemes in minimizing latency, which shows the proposed method’s superiority in processing the multi-source data stream.
An overview of systems for providing integrated and comprehensive care for older people in Japan
Authors: Sano Junko , Hirazawa Yuzuki , Komamura Kohei , Okamoto Shohei 
Published: May 2023

AbstractAs longevity occurs, people encounter various risks associated with ageing, including economic uncertainty and health issues. Therefore, in addition to extending healthy life expectancy, it is crucial to create an environment where older people can live better even when their intrinsic capacity declines. Additionally, integrated and comprehensive care for older adults is needed to maintain their functional ability and well-being at higher levels. This review provides an overview of the systems and initiatives in Japan, a forerunner of population ageing that supports the quality of life of older people and summarises their remaining challenges. In Japan, with support for access to necessary care available from social welfare councils and community comprehensive support centres, various health and welfare services are provided to respond to the needs of people with different levels of intrinsic capacity, including medical care, preventive care, long-term care, adult guardianship systems, pensions, and social assistance. Nevertheless, there are challenges for the systems, including the gap between life and healthy life expectancy, moderate accumulation and decumulation of retirement assets, lack of human and financial resources for care, and user-unfriendliness and non-covered needs of the current system. Therefore, integrated and comprehensive care beyond health and long-term care is needed to maintain the well-being of older adults, even with their intrinsic capacity declining.
Treating opioid use disorder in veterans with co-occurring substance use: a qualitative study with buprenorphine providers in primary care, mental health, and pain settings
Authors: Frost Madeline C. , Soyer Elena M. , Achtmeyer Carol E. , Hawkins Eric J. , Glass Joseph E. , Hallgren Kevin A. , Williams Emily C. 
Published: May 2023

Abstract
Background
Most people with opioid use disorder (OUD) have co-occurring substance use, which is associated with lower receipt of OUD medications (MOUD). Expanding MOUD provision and care linkage outside of substance use disorder (SUD) specialty settings is a key strategy to increase access. Therefore, it is important to understand how MOUD providers in these settings approach care for patients with co-occurring substance use. This qualitative study of Veterans Health Administration (VA) clinicians providing buprenorphine care in primary care, mental health, and pain settings aimed to understand (1) their approach to addressing OUD in patients with co-occurring substance use, (2) perspectives on barriers/facilitators to MOUD receipt for this population, and (3) support needed to increase MOUD receipt for this population.

Methods
We interviewed a purposive sample of 27 clinicians (12 primary care, 7 mental health, 4 pain, 4 pharmacists) in the VA northwest network. The interview guide assessed domains of the Tailored Implementation for Chronic Diseases Checklist. Interviews were transcribed and qualitatively analyzed using inductive content analysis.

Results
Participants reported varied approaches to identifying co-occurring substance use and addressing OUD in this patient population. Although they reported that this topic was not clearly addressed in clinical guidelines or training, participants generally felt that patients with co-occurring substance use should receive MOUD. Some viewed their primary role as providing this care, others as facilitating linkage to OUD care in SUD specialty settings. Participants reported multiple barriers and facilitators to providing buprenorphine care to patients with co-occurring substance use and linking them to SUD specialty care, including provider, patient, organizational, and external factors.

Conclusions
Efforts are needed to support clinicians outside of SUD specialty settings in providing buprenorphine care to patients with co-occurring substance use. These could include clearer guidelines and policies, more specific training, and increased care integration or cross-disciplinary collaboration. Simultaneously, efforts are needed to improve linkage to specialty SUD care for patients who would benefit from and are willing to receive this care, which could include increased service availability and improved referral/hand-off processes. These efforts may increase MOUD receipt and improve OUD care quality for patients with co-occurring substance use.
Synthesis of Existent Oncology Curricula for Primary Care Providers: A Scoping Review With a Global Equity Lens
Authors: Oldfield Leslie E. , Jones Vivien , Gill Bhajan , Kodous Nardeen , Fazelzad Rouhi , Rodin Danielle , Sandhu Harminder , Umakanthan Ben , Papadakos Janet , Giuliani Meredith Elana 
Published: May 2023

PURPOSE Global increases in cancer, coupled with a shortage of cancer specialists, has led to an increasing role for primary care providers (PCP) in cancer care. This review aimed to examine all extant cancer curricula for PCPs and to analyze the motivations for curriculum development. METHODS A comprehensive literature search was conducted from inception to October 13, 2021, with no language restrictions. The initial search yielded 11,162 articles and 10,902 articles underwent title and abstract review. After full-text review, 139 articles were included. Numeric and thematic analyses were conducted and education programs were evaluated using Bloom's taxonomy. RESULTS Most curricula were developed in high-income countries (HICs), with 58% in the United States. Cancer-specific curricula focused on HIC priority cancers, such as skin/melanoma, and did not represent the global cancer burden. Most (80%) curricula were developed for staff physicians and 73% focused on cancer screening. More than half (57%) of programs were delivered in person, with a shift toward online delivery over time. Less than half (46%) of programs were codeveloped with PCPs and 34% did not involve PCPs in the program design and development. Curricula were primarily developed to improve cancer knowledge, and 72 studies assessed multiple outcome measures. No studies included the top two levels of Bloom's taxonomy of learning (evaluating; creating). CONCLUSION To our knowledge, this is the first review to assess the current state of cancer curricula for PCPs with a global focus. This review shows that extant curricula are primarily developed in HICs, do not represent the global cancer burden, and focus on cancer screening. This review lays a foundation to advance the cocreation of curricula that are aligned to the global cancer burden.
A Gene Panel Associated With Abemaciclib Utility in ESR1-Mutated Breast Cancer After Prior Cyclin-Dependent Kinase 4/6-Inhibitor Progression
Authors: Brett Jamie O. , Dubash Taronish D. , Johnson Gabriela N. , Niemierko Andrzej , Mariotti Veronica , Kim Leslie S.L. , Xi Jing , Pandey Apurva , Dunne Siobhan , Nasrazadani Azadeh , Lloyd Maxwell R. , Kambadakone Avinash , Spring Laura M. , Micalizzi Douglas S. , Onozato Maristela L. , Che Dante , Nayar Utthara , Brufsky Adam , Kalinsky Kevin , Ma Cynthia X. , O'Shaughnessy Joyce , Han Hyo S. , Iafrate Anthony J. , Ryan Lianne Y. , Juric Dejan , Moy Beverly , Ellisen Leif W. , Maheswaran Shyamala , Wagle Nikhil , Haber Daniel A. , Bardia Aditya , Wander Seth A. 
Published: May 2023

PURPOSE For patients with hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative (HER2–) metastatic breast cancer (MBC), first-line treatment is endocrine therapy (ET) plus cyclin-dependent kinase 4/6 inhibition (CDK4/6i). After disease progression, which often comes with ESR1 resistance mutations (ESR1-MUT), which therapies to use next and for which patients are open questions. An active area of exploration is treatment with further CDK4/6i, particularly abemaciclib, which has distinct pharmacokinetic and pharmacodynamic properties compared with the other approved CDK4/6 inhibitors, palbociclib and ribociclib. We investigated a gene panel to prognosticate abemaciclib susceptibility in patients with ESR1-MUT MBC after palbociclib progression. METHODS We examined a multicenter retrospective cohort of patients with ESR1-MUT MBC who received abemaciclib after disease progression on ET plus palbociclib. We generated a panel of CDK4/6i resistance genes and compared abemaciclib progression-free survival (PFS) in patients without versus with mutations in this panel (CDKi-R[–] v CDKi-R[+]). We studied how ESR1-MUT and CDKi-R mutations affect abemaciclib sensitivity of immortalized breast cancer cells and patient-derived circulating tumor cell lines in culture. RESULTS In ESR1-MUT MBC with disease progression on ET plus palbociclib, the median PFS was 7.0 months for CDKi-R(–) (n = 17) versus 3.5 months for CDKi-R(+) (n = 11), with a hazard ratio of 2.8 ( P = .03). In vitro, CDKi-R alterations but not ESR1-MUT induced abemaciclib resistance in immortalized breast cancer cells and were associated with resistance in circulating tumor cells. CONCLUSION For ESR1-MUT MBC with resistance to ET and palbociclib, PFS on abemaciclib is longer for patients with CDKi-R(–) than CDKi-R(+). Although a small and retrospective data set, this is the first demonstration of a genomic panel associated with abemaciclib sensitivity in the postpalbociclib setting. Future directions include testing and improving this panel in additional data sets, to guide therapy selection for patients with HR+/HER2– MBC.
The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesis
Authors: Lupan Bianca M. , Solecki Rachel A. , Musso Camila M. , Alsina Fernando C. , Silver Debra L. 
Published: May 2023

ABSTRACT
Mutations in components of the exon junction complex (EJC) are associated with neurodevelopment and disease. In particular, reduced levels of the RNA helicase EIF4A3 cause Richieri-Costa-Pereira syndrome (RCPS) and copy number variations are linked to intellectual disability. Consistent with this, Eif4a3 haploinsufficient mice are microcephalic. Altogether, this implicates EIF4A3 in cortical development; however, the underlying mechanisms are poorly understood. Here, we use mouse and human models to demonstrate that EIF4A3 promotes cortical development by controlling progenitor mitosis, cell fate and survival. Eif4a3 haploinsufficiency in mice causes extensive cell death and impairs neurogenesis. Using Eif4a3;p53 compound mice, we show that apoptosis has the most impact on early neurogenesis, while additional p53-independent mechanisms contribute to later stages. Live imaging of mouse and human neural progenitors reveals that Eif4a3 controls mitosis length, which influences progeny fate and viability. These phenotypes are conserved, as cortical organoids derived from RCPS iPSCs exhibit aberrant neurogenesis. Finally, using rescue experiments we show that EIF4A3 controls neuron generation via the EJC. Altogether, our study demonstrates that EIF4A3 mediates neurogenesis by controlling mitosis duration and cell survival, implicating new mechanisms that underlie EJC-mediated disorders.
Practice and knowledge of dietary supplement consumption among Indonesian adults post-delta wave of the COVID-19 pandemic
Authors: d'Arqom Annette , Nasution Mhd Zamal , Kadir Sharifah Zamiah Syed Abdul , Yusof Junaidah , Govindaraju Kayatri 
Published: May 2023

Background: Increasing dietary supplement (DS) consumption was observed during the COVID-19 pandemic, including during the post-Delta wave period. This study aimed to measure the practice of DS consumption and respondents’ knowledge of DS. Methods: An internet-based survey was distributed from October-December 2021 and obtained 541 valid and completed responses. Descriptive analysis was performed to present the practice of DS consumption, including frequency, duration, aim, preferable dosage form etc. Level of knowledge on DS principles, side effects and regulation were also measured. Inferential analyses were conducted to determine the predictors of the respondents’ DS practice and level of knowledge. Results: Data from 541 valid responses showed that 77.63% of respondents consumed DS in the last 3 months, with only 59.52% reporting also consuming DS before the COVID-19 pandemic. One half of the respondents had good knowledge about DS; however, some knowledge regarding side effects and possible drug-supplement interaction needed improvement. Their DS consumption practice was affected by their economic status and history of contracting COVID-19. Nevertheless, the level of knowledge was not affected by the sociodemographic factors and DS supplement experience. Conclusions: Taken together, the practice of self-consumption of DS in Indonesia is increasing; hence, knowledge of DS is necessary to avoid detrimental effects that might occur in the future. Increasing access to information on better labelling and educating consumers about DS are important actions to consider.
Physiotherapy versus pain medication for managing chronic cervical radiculopathy: protocol for a multi-arm parallel-group randomized clinical trial
Authors: Siddique Mustafa Amimul Ehsan , Rahman M. Mazibar , Islam Md. Shofiqul , Islam Md. Waliul , Islam Nasirul , Uddin Zakir , Hossain Shahadat , Akter Sapia , Ali Mohammad , Hossain K. M. Amran 
Published: May 2023

Background: Cervical radiculopathy (CR) is one of the prevalent causes of neck pain and disability. Physiotherapy and pain medications are the common nonoperative management, and in physiotherapy, there are many concepts of assessment and management. This study aims to determine the comparative effectiveness of three specialized physiotherapy approaches or only pain medications for managing CR cases. Methods: A prospective, assessor, and participant-blind, four-arm randomized control trial (RCT) has been planned to conduct on 160 patients with chronic cervical radiculopathy in 4 specialized centers of Dhaka city recruited between July and December 2022. Four groups (n=40) will be treated through structural diagnosis and management concept (SDM), regional approaches (RA), McKenzie mechanical diagnosis and therapy (MDT) concept prescribed by advanced practice physiotherapist (APP), or pain medications prescribed by the specialist physician for 4 weeks. The outcome will be evaluated in baseline, intermediate test (14 days), and post-treatment (28 days) through Brief Pain Inventory (BPI) for pain, Goniometer reading for cervical range of motion (ROM), and Neck disability index (NDI) as the primary outcome. The secondary outcome will be quality of life measured at baseline and post-treatment by the WHO quality of life questionnaire WHOQOL-BREF. Discussion: The study will compare the efficacy of the three physiotherapy approaches with pain medications when treating chronic cervical radiculopathy. The findings will provide evidence when demining the best conservative management approach for CR. Clinical Trial Registry India: CTRI/2022/03/040922 (08/03/2022)
Mathematical modeling of the dependence of the risk of vitamin D deficiency on anthropometric and laboratory parameters
Authors: Shanyhin Anton , Babienko Volodymyr , Strakhov Yevhen , Korkhova Arina 
Published: May 2023

Recently, data on the use of mathematical models to determine the status of vitamin D in clinical practice in patients with various diseases appear in the literature, but there is no data on the creation of a mathematical model that allows screening in the general population. The creation of a mathematical model, with the help of which it is possible to identify groups at risk of vitamin D deficiency, will contribute to the reduction of laboratory research costs and allow screening of vitamin D status on a more massive and reasonable basis.
Goal. Study of the relationship between the risk of vitamin D deficiency and anthropometric and laboratory parameters using mathematical modeling methods.
Materials and methods. 928 residents of the southern region of Ukraine between the ages of 19 and 82 (average age - 47.2 years) were surveyed. Based on the correlation analysis of the studied data, the most influential data were selected as the following indicators: age, body mass index, atherogenicity coefficient, high-density lipoproteins, and the ratio of waist volume to hip volume.
Conclusions. The study emphasizes the importance of anthropometric and laboratory parameters in predicting the risk of vitamin D deficiency. The use of mathematical modeling methods makes it possible to identify the most important risk factors and quantify their contribution. The results of the study may have important implications for public health by helping to identify high-risk groups in a timely manner.
New biologically active allelochemical from the leaves of Dalbergia Paniculata Roxb
Authors: Singh Alok Kumar , Yadava Raj Nath , Yadav Ritu , Shreevastava Satya Prakash 
Published: May 2023

A new biologically active Allelochemical 3,5,7,3’,4’-pentahydroxyflavone-3<em>-O-β</em>-<em>D </em>xylopyranosyl -(1→4)- <em>β-D</em>-glucopyranosyl-4<sup>’</sup>-<em>O-α-</em>L-arabinoside (<strong>A</strong><sub>1</sub><strong>) </strong>whose m.p. is 340–345 <sup>0</sup>C, m.f. [M<sup>+</sup>] 728 (EIMS) was isolated from methanolic leaf extracts of<strong> </strong><em>Dalbergia paniculata</em> Roxb. It was characterized by several color reactions, spectral analysis FTIR, <sup>1</sup>H-NMR, GC-MS, and chemical degradations. The results of the antimicrobial activity of <strong>(A<sub>1</sub>) </strong>at high concentration (100µg/mL) was 20, 17, and 15 mm zone of inhibition against <em>E. coli</em>, <em>B. cereus, </em>and <em>S. aureus aeruginosa, </em>respectively. The data demonstrated that the antimicrobial activity of CH<sub>3</sub> OH soluble fraction <strong>(A<sub>1 </sub>) </strong>at all concentrations was highest against <em>E. coli</em> and lowest<em> S. aureus.</em> <em>E. coli</em>, <em>B. cereus, </em>and <em>S. aureus aeruginosa, </em>respectively 7.3, 2.1, and 0.02mm, MIC was defined as the minimum concentration of assayed samples that inhibited the visible growth of the tested microorganism<em>. </em>MIC in <em>E. coli</em>, <em>B. cereus, </em>and <em>S. aureus aeruginosa </em>was 7.3, 2.1, and 0.02mm, respectively.
One pot synthesis of some novel indole derivatives and their antimicrobial activity
Authors: Dangi Hemlata , Roy Atish , Chanderiya Aayushi , Kashaw Sushil , Das Ratnesh 
Published: May 2023

<p>In this study, we describe the creation of a straightforward and incredibly effective protocol for the synthesis of new 3-Substituted indole derivatives. This multicomponent reaction involved indole, acetylacetone and active aldehyde derivatives in the presence of ethanol as solvent followed by acetonitrile as a base. We go through current developments in organic synthesis methodology for multicomponent reactions that produce substituted indole derivatives with a more environmentally friendly base catalytic condition, as well as the applications that go along with them. FT-IR, 1H-NMR and MS are used to characterise the synthesized compound of indole derivatives. Antibacterial activity of synthesized compounds has also been done. </p>
Microwave-assisted synthesis, spectral characterization and DFT studies of Zn(II) complexes based on N-acylhydrazone ligands: stability and antioxidant activity
Authors: Santos Daniela Corrêa , Henriques Ruan Roberto , Lopes Jr Marcos Antonio Abreu , Maia Paulo José Sousa , Silva Andreza Miranda Barata , Paschoal Diego Fernando Silva , Souza Andréa Luzia Ferreira 
Published: May 2023

<p class="03Abstract">This article reports the synthesis of seven Zn(II) complexes containing <em>N</em>-acylhydrazone ligands (<strong>L1 </strong>to<strong> L7</strong>) and the assessment of their antioxidant. Microwave assisted-synthesis of ligands with ZnCl<sub>2</sub> in MeOH yielded tetrahedral Zn(II) complexes with a 1:2 metal: ligand ratio, characterized by HRMS, FTIR, and UV-Vis spectroscopy, thermal and electrochemical analyses, and DFT calculations. The <strong>(L3)<sub>2</sub>Zn</strong> complex exhibited the lowest thermal stability, and <strong>(L6)<sub>2</sub>Zn</strong> and <strong>(L7)<sub>2</sub>Zn</strong> were the most stable. XRD powder showed that all complexes have good crystallinity with crystalline dimensions ranging from 32 to 86 nm. Cyclic voltammetry of Zn(II) complexes indicated a reversible redox process for <strong>(L4)<sub>2</sub>Zn</strong> and an irreversible process for the remaining six complexes: <strong>(L1)<sub>2</sub>Zn </strong>to <strong>(L3)<sub>2</sub>Zn</strong> and <strong>(L5)<sub>2</sub>Zn</strong> to <strong>(L7)<sub>2</sub>Zn</strong>. Antioxidant activity of ligands and complexes was assessed by the DPPH method; the <strong>L7 </strong>ligand and corresponding <strong>(L7)<sub>2</sub>Zn</strong> complex exhibited good activity, IC<sub>50</sub> = 65.30 μmol.l<sup>-1 </sup>and 78.70 μmol.l<sup>-1</sup>, respectively, when compared with standard ascorbic acid. <strong></strong></p>