bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toxicity, Leakage, and Recycling of Lead in Perovskite Photovoltaics
Authors: Chen Chun‐Hao , Cheng Shu‐Ning , Cheng Liang , Wang Zhao‐Kui , Liao Liang‐Sheng 
Published: February 2023

AbstractPerovskite solar cells (PSCs) have developed rapidly in recent years due to their excellent photoelectric properties. Among them, lead‐based perovskite photovoltaics have shown great potential for both outdoor and indoor applications, whose power conversion efficiency and stability are much higher than that of lead‐free PSCs. However, based on results of in vivo animal studies, Kyoto Encyclopedia of Genes and Genomes annotations and pathway analysis of microbiota and metabolites influenced by lead, it has been proved that lead exposure from PSCs probably causes systematic toxicity to human body. For the purpose of reducing lead leakage, some methods mainly based on polymer resin protective layers and self‐healing encapsulation have been introduced, which can increase lead capture rate up to 95% under harsh conditions. Eventually, the devices will still face damage and obsolescence, accompanied by lead leakage into the environment. Comprehensive recycling strategies are necessary to solve this problem from the root and also shorten the energy payback time for further transformation and upgrading of green energy. The vertical and in‐depth collaborative strategy for lead leakage prevention and comprehensive recycling would provide an environmentally‐friendly guarantee for the final large‐scale market of perovskite photovoltaics.
Long‐term outcomes between self‐expandable metallic stent and transanal decompression tube for malignant large bowel obstruction: A multicenter retrospective study and meta‐analysis
Authors: Matsuda Akihisa , Yamada Takeshi , Yokoyama Yasuyuki , Takahashi Goro , Yoshida Hiroshi 
Published: February 2023

AbstractAimTo compare the oncological outcomes between self‐expandable metallic stent (SEMS) as a bridge to surgery and transanal decompression tube (TDT) placement for malignant large bowel obstruction (MLBO).MethodsA total of 287 MLBO patients who underwent SEMS (n = 137) or TDT placement (n = 150) were enrolled in this multicenter retrospective study. Overall survival (OS) and disease‐free survival (DFS) between the two groups were compared. A meta‐analysis was performed using random‐effects models to calculate odd ratios (OR) with 95% confidence intervals (CIs).ResultsPostoperative complications of Clavien–Dindo grade ≥II and ≥III occurred frequently in the TDT group compared with the SEMS group (P = 0.002 and 0.005, respectively). The 3‐y OS in the overall cohort and 3‐y DFS in the pathological stage II/III cohort in the SEMS and TDT groups were 68.6% and 71.4%, and 71.0% and 72.6%, respectively. The survival differences were not significantly different in the OS and DFS analyses (P = 0.819 and P = 0.892, respectively). A meta‐analysis of nine studies (including our cohort data) demonstrated no significant difference between the SEMS and TDT groups for 3‐y OS and DFS (OR = 0.96, 95% CI = 0.57–1.62, P = 0.89 and OR = 0.69, 95% CI = 0.46–1.04, P = 0.07, respectively).ConclusionOur study demonstrated that SEMS placement had no inferiority regarding long‐term outcomes, including OS and DFS, compared with TDT placement. Considering the short‐term benefits of SEMS placement, this could be a preferable preoperative decompression method for MLBO.
Co‐occurrence of Proteus syndrome and ventricular tachycardia cardiac arrest in a teenager
Authors: Ferguson Richard , Scurr Ingrid , Ours Christopher A. , Johnston Jennifer J. , Pike Katharine , Spentzou Georgia 
Published: February 2023

AbstractProteus syndrome is an extremely rare overgrowth condition caused by a somatic variant of the AKT1 gene. It can involve multiple organ systems though rarely is there symptomatic cardiac involvement. Fatty infiltration of the myocardium has been described but has not been reported to cause functional or conduction abnormalities. We present an individual with Proteus syndrome who suffered a sudden cardiac arrest.
Mechanochemical devulcanization ofEPDMrubber waste. Correlation of process parameters with sol–gel analyses and revulcanization properties
Authors: Gschwind Larissa , Jordan Carmen‐Simona , Vennemann Norbert , Susoff Markus L. 
Published: February 2023

AbstractEthylene–propylene–diene rubber (EPDM) scrap was devulcanized in an internal mixer with varying amounts of dibenzamido diphenyl disulfide (DBD) at temperatures below 200°C. The devulcanization effect and sol–gel analyses of the devulcanizates, and the mechanical properties of the sulfur‐cured revulcanizates were studied. Residual DBD was still present in the sol at 160°C and degraded DBD at 200°C. DBD affects the curing leading to poor properties. So, the temperature must be adjusted according to the DBD concentration to obtain a superior recyclate for sealing systems. At 0.4 wt% DBD, the degradation reaction was already complete at 120°C, but only 52% and 61% of the tensile strengthσand strain at breakεof the virgin material were achieved. At 160°C and 2 wt%, the degradation reaction was complete, and the DBD effect on properties was small; 65% and 86% ofσandεwere recovered, respectively. To prevent property degradation, 200°C was required at 3.9 wt% DBD, resulting in 97% and 95% ofσandε, but only 70% of hardness.
Amplification of blue emission of Tm3+ ions in Li2O‐HfO2‐SiO2 glass system by means of Au0 metallic particles
Authors: Devi Pilli Pavani Koteswari , Sekhar Ayyagari Venkata , Kumar Valluri Ravi , Baskaran Gnanamuthu Sahaya , Venkatramaiah Nutalapati , Kumar Vandana Ravi , Veeraiah Nalluri 
Published: February 2023

AbstractLi2O‐HfO2‐SiO2‐Tm2O3:Au2O3 glass samples (containing fixed content of Tm2O3 and different concentration of Au2O3) were prepared and characterized. Bearing of Au0 metallic particles (MPs) on improving blue emission of thulium ions (Tm3+) ions was explored. Optical absorption (OA) spectra exhibited multiple bands excited from 3H6 of Tm3+. Additionally, a broad peak in the wavelength range 500–600 nm due to surface plasmon resonance (SPR) of Au0 MPs was noticed in the spectra. Photoluminescence (PL) spectra (of thulium free glasses) indicated a peak in the visible range due to sp → d electronic transition of Au0 MPs. Luminescence spectra of Tm3+ and Au2O3 co‐doped glasses exhibited intense blue emission with substantial increase of intensity with increase of Au2O3 content. Bearing of Au0 MPs on the reinforcement of blue emission of Tm3+ was discussed in detail with kinetic rate equations.
Psychosocial factors impacting barriers and motivators to cancer genetic testing
Authors: Hanson Erika N. , Delacroix Emerson , Austin Sarah , Carr Grant , Kidwell Kelley M. , Bacon Elizabeth , Gerido Lynette Hammond , Griggs Jennifer J. , Stoffel Elena M. , Resnicow Ken 
Published: February 2023

AbstractBackgroundOnly a small proportion of patients who qualify for clinical genetic testing for cancer susceptibility get testing. Many patient‐level barriers contribute to low uptake. In this study, we examined self‐reported patient barriers and motivators for cancer genetic testing.MethodsA survey comprised of both new and existing measures related to barriers and motivators to genetic testing was emailed to patients with a diagnosis of cancer at a large academic medical center. Patients who self‐reported receiving a genetic test were included in these analyses (n = 376). Responses about emotions following testing as well as barriers and motivators prior to getting testing were examined. Group differences in barriers and motivators by patient demographic characteristics were examined.ResultsBeing assigned female at birth was associated with increased emotional, insurance, and family concerns as well as increased health benefits compared to patients assigned male at birth. Younger respondents had significantly higher emotional and family concerns compared to older respondents. Recently diagnosed respondents expressed fewer concerns about insurance implications and emotional concerns. Those with a BRCA‐related cancer had higher scores on social and interpersonal concerns scale than those with other cancers. Participants with higher depression scores indicated increased emotional, social and interpersonal, and family concerns.ConclusionsSelf‐reported depression emerged as the most consistent factor influencing report of barriers to genetic testing. By incorporating mental health resources into clinical practice, oncologists may better identify those patients who might need more assistance following through with a referral for genetic testing and the response afterwards.
Design, Synthesis of 3‐(5‐Substituted Phenyl‐[1,3,4]oxadiazol‐2‐yl)‐1H‐indole and Its Microbial Activity
Authors: Suryawanshi Manohar D. , Suryawanshi Ganesh D. , Mhaske Pravin C. , Karpe Dnyaneshwar G. , Kamble Komal R. , Rode Sagar J. , Sudrik Vilas A. , Lawande Shamrao P. 
Published: February 2023

AbstractFischer indole synthesis of indole by using phenyl‐hydrazine and acetaldehyde resulted 1H‐Indole while phenyl‐hydrazine reacted with malonaldehyde gives 1H‐Indole‐3‐carbaldehyde. Also Vilsmeier‐Haack formylation of 1H‐Indole gives 1H‐Indole‐3‐carbaldehyde. 1H‐Indole‐3‐carbaldehyde were oxidized to form 1H‐Indole‐3‐carboxylic acid. 1H‐Indole reacted with excess of BuLi at −78 °C using dry ice also gives 1H‐Indole‐3‐carboxylic acid. Obtained 1H‐Indole‐3‐carboxylic acid was converted to ester and ester in to acid hydrazide. Finally 1H‐Indole‐3‐carboxylic acid hydrazide reacted with substituted carboxylic acid gives microbial active indole substituted oxadiazoles. Synthesized compounds 9a–j showing promising in vitro anti microbial activities against S. aureus bacteria compared with Streptomycin. Compound 9a, 9f and 9g showing activities against E. coli compared with standards. Compound 9a and 9f are found potent active against B. subtilis compared with reference standard while compound 9a, 9c and 9j active against S. typhi.
Radius‐Maumenee syndrome: A case series with a long‐term follow‐up
Authors: Elksne Eva , Steiner Veit , Hohensinn Melchior , Reitsamer Herbert A. , Lenzhofer Markus 
Published: February 2023

AbstractThe aim of the case series is to highlight the surgical challenges experienced like failed intervention, choroidal effusion, a postoperative cystoid macular oedema, and describe treatment options for Radius‐Maumenee syndrome. Authors reported on 3 bilateral cases of Radius‐Maumenee syndrome which underwent medical treatment, trabeculectomy with Mitomycin C, implantation with XEN45, Ahmed glaucoma valve, Baerveldt glaucoma implant, and cyclophotocoagulation.
Sporadic unilateral papillary renal cell carcinoma masquerading pyelonephritis: A case report
Authors: Guguloth Mohan Nayak , Manzoor Juhi , Kuchana Sai Kiran , Suvvari Tarun Kumar , Gopu Anthony Reddy , Kunden Vikram Das , Bhattarai Sashank , Anand Ayush 
Published: February 2023

AbstractHidden renal cell carcinoma (RCC) is not evident during severe inflammation such as acute pyelonephritis. We presented a 62‐year‐old male presenting with features of obstructive pyelonephritis managed with simple nephrectomy. However, the histopathology findings suggested unilateral papillary RCC. Our case showed that RCC might present with features of obstructive pyelonephritis.
Doctoral students’ experiences of nondisclosure with their dissertation chair
Authors: Cook Ryan M. , Crabtree Rachel , Sackett Corrine R. , Baylin Andrea , Sharma Jyotsana 
Published: February 2023

AbstractWe examined doctoral students’ experiences of nondisclosure with their dissertation chairs. Using a hermeneutic phenomenology design, we analyzed two individual interviews of 10 doctoral students. We identified the following three themes: (a) the professional dynamics in the relationship, (b) the interpersonal and cultural dynamics in the relationship, and (c) prioritization of completing the dissertation. Implications for doctoral students and dissertation chairs are discussed.
Can Copper(I) and Silver(I) be Hydrogen Bond Acceptors?
Authors: Andris Erik , Straka Michal , Vrána Jan , Růžička Aleš , Roithová Jana , Rulíšek Lubomír 
Published: February 2023

AbstractGold(I) centers can form moderately strong (Au⋅⋅⋅H) hydrogen bonds with tertiary ammonium groups, as has been demonstrated in the 3AuCl+ (3+=1‐(tert‐butyl)‐3‐phenyl‐4‐(2‐((dimethylammonio)methyl)phenyl)‐1,2,4‐triazol‐5‐ylidene) complex. However, similar hydrogen bonding interactions with isoelectronic silver(I) or copper(I) centers are unknown. Herein, we first explored whether the Au⋅⋅⋅H bond originally observed in 3AuCl+ can be strengthened by replacing Cl with Br or I. Experimental gas‐phase IR spectra in the ∼3000 cm−1 region showed only a small effect of the halogen on the Au⋅⋅⋅H bond. Next, we measured the spectra of 3AgCl+, which exhibited significant differences compared to its 3AuX+ counterparts. The difference has been explained by DFT calculations which indicated that the Ag⋅⋅⋅H interaction is only marginal in this complex, and a Cl⋅⋅⋅H hydrogen bond is formed instead. Calculations predicted the same for the 3CuCl+ complex. However, we noticed that for Ag and Cu complexes with less flexible ligands, such as dimethyl(2‐(dimethylammonio)phenyl)phosphine (L7H+), the computations predict the presence of the respective Ag⋅⋅⋅H and Cu⋅⋅⋅H hydrogen bonds, with a strength similar to the Au⋅⋅⋅H bond in 3AuCl+. We, therefore, propose possible complexes where the presence of (Ag/Cu)⋅⋅⋅H bonds could be experimentally verified to broaden our understanding of these unusual interactions.
Marigold Flower‐Shaped Metal–Organic Framework Supported Manganese Vanadium Oxide Electrocatalyst for Efficient Oxygen Evolution Reactions in an Alkaline Medium
Authors: Ji Seong‐Min , Muthurasu Alagan , Kim Hak Yong 
Published: February 2023

AbstractThe electrochemical oxygen evolution reaction (OER) is a key process in many renewable energy systems. The development of low‐cost, long‐lasting alternatives to precious‐metal catalysts, particularly functional electrocatalysts with high activity for OER processes, is crucial for reducing the operating expense and complexity of renewable energy generating systems. This work describes a concise method for generating marigold flower‐like metal–organic frameworks (MOFs) aided manganese vanadium oxide via a hydrothermal procedure for increased OER activity. As synthesized MOF MnV oxide has a higher surface area due to the 3D flower‐like structure, which is reinvented with enhanced electrocatalytic active sites. These distinctive structural features result in remarkable catalytic activity for MOF MnV oxide microflowers towards OER with a low overpotential of 310 mV at 50 mA cm−2 and a Tafel slope with only 51.4 mV dec−1 in alkaline conditions. This study provides a concise method for developing an optimized catalytic material with greater morphology and beneficial features for potential energy and environmental applications.
High‐risk human papillomavirus 16/18 associated with improved survival in sinonasal squamous cell carcinoma
Authors: Ramkumar Shreya P. , Simpson Matthew C. , Adjei Boakye Eric , Bukatko Aleksandr R. , Antisdel Jastin L. , Massa Sean T. , Osazuwa‐Peters Nosayaba 
Published: February 2023

AbstractBackgroundThere has been conflicting evidence on the independent prognostic role of human papillomavirus (HPV) status in sinonasal cancer. The objective of this study was to assess whether the survival of patients with sinonasal cancer differs based on various HPV statuses, including HPV‐negative, positive for the high‐risk HPV‐16 and HPV‐18 (HPV16/18) subtypes, and positive for other high‐risk and low‐risk HPV subtypes.MethodsIn this retrospective cohort study, data from the National Cancer Database were extracted from the years 2010–2017 for patients who had primary sinonasal cancer (N = 12,009). The outcome of interest was overall survival based on HPV tumor status.ResultsStudy included an analytic cohort of 1070 patients with sinonasal cancer who had confirmed HPV tumor status (732 [68.4%] HPV‐negative; 280 [26.2%] HPV16/18‐positive; 40 [3.7%] positive for other high‐risk HPV; and 18 [1.7%] positive for low‐risk HPV). HPV‐negative patients had the lowest all‐cause survival probability at 5 years postdiagnosis (0.50). After controlling for covariates, HPV16/18‐positive patients had a 37% lower mortality hazard than HPV‐negative patients (adjusted hazard ratio, 0.63; 95% confidence interval [CI], 0.48–0.82). Patients aged 64–72 years (crude prevalence ratio, 0.66; 95% CI, 0.51–0.86) and 73 years and older (crude prevalence ratio, 0.43; 95% CI, 0.31–0.59) presented with lower rates of HPV16/18‐positive sinonasal cancer than those aged 40–54 years. In addition, Hispanic patients had a 2.36 times higher prevalence of non‐HPV16/18 sinonasal cancer than non‐Hispanic White patients.ConclusionsThese data suggest that, for patients with sinonasal cancer, HPV16/18‐positive disease may confer a significant survival advantage compared with HPV‐negative disease. Other high‐risk and low‐risk HPV subtypes have survival rates similar to the rates for HPV‐negative disease. HPV status might be an important independent prognostic factor in sinonasal cancer that could be used in patient selection and clinical decisions.
A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of Savolitinib in Healthy Male Volunteers
Authors: Miah Kowser , Vishwanathan Karthick , Scarfe Graeme , Li Yan , Hara Indira , Cantarini Mireille , Argue John , Menakuru Somasekhar R. 
Published: February 2023

AbstractSavolitinib is an oral MET (hepatocyte growth factor receptor) tyrosine kinase inhibitor, with demonstrated preliminary efficacy in several cancer types. Previous pharmacokinetics assessments showed that savolitinib is rapidly absorbed but there are limited data on the absolute bioavailability and absorption, distribution, metabolism, and excretion (ADME) of savolitinib. This open‐label, two‐part, phase 1 clinical study (NCT04675021) used a radiolabeled micro‐tracer approach to evaluate absolute bioavailability and a traditional approach to determine the ADME of savolitinib in healthy male adult volunteers (N = 8). Pharmacokinetics, safety, and metabolic profiling and structural identification from plasma, urine, and fecal samples were also assessed. Volunteers received a single oral savolitinib 600 mg dose followed by intravenous 100 μg of [14C]savolitinib in Part 1 and a single oral 300 mg [14C]savolitinib dose (≤4.1 MBq [megabecquerel] [14C]) in Part 2. Following Part 1, absolute oral bioavailability was 69%, the median time of maximum observed concentration was 3.5 hours, and the mean terminal half‐life was 6.1 hours. Following Part 2, 94% of the radioactivity administered was recovered, with 56% and 38% in urine and feces, respectively. Exposure to savolitinib and metabolites M8, M44, M2, and M3 accounted for 22%, 36%, 13%, 7%, and 2%, respectively, of plasma total radioactivity. Approximately 3% of the dose was excreted as unchanged savolitinib in urine. Most savolitinib elimination occurred via metabolism by several different pathways. No new safety signals were observed. Our data show that the oral bioavailability of savolitinib is high and the majority of savolitinib elimination occurs via metabolism and is excreted in the urine.
Self‐Induced and Progressive Photo‐Oxidation of Organophosphonic Acid Grafted Titanium Dioxide
Authors: Gys Nick , Pawlak Bram , Marcoen Kristof , Reekmans Gunter , Velasco Leticia F. , An Rui , Wyns Kenny , Baert Kitty , Zhang Kaimin , Luntadila Lufungula Léon , Piras Alessandra , Siemons Laurens , Michielsen Bart , Van Doorslaer Sabine , Blockhuys Frank , Hauffman Tom , Adriaensens Peter , Mullens Steven , Meynen Vera 
Published: February 2023

AbstractWhile synthesis‐properties‐performance correlations are being studied for organophosphonic acid grafted TiO2, their stability and the impact of the exposure conditions on possible changes in the interfacial surface chemistry remain unexplored. Here, the impact of different ageing conditions on the evolution of the surface properties of propyl‐ and 3‐aminopropylphosphonic acid grafted mesoporous TiO2 over a period of 2 years is reported, using solid‐state 31P and 13C NMR, ToF‐SIMS and EPR as main techniques. In humid conditions under ambient light exposure, PA grafted TiO2 surfaces initiate and facilitate photo‐induced oxidative reactions, resulting in the formation of phosphate species and degradation of the grafted organic group with a loss of carbon content ranging from 40 to 60 wt %. By revealing its mechanism, solutions were provided to prevent degradation. This work provides valuable insights for the broad community in choosing optimal exposure/storage conditions that extend the lifetime and improve the materials′ performance, positively impacting sustainability.
Clinical signs in the jaw and neck region following whiplash trauma—A 2‐year follow‐up
Authors: Böthun Alicia , Häggman‐Henrikson Birgitta , Stålnacke Britt‐Marie , Wänman Anders , Nordh Erik , Lampa Ewa , Hellström Fredrik 
Published: February 2023

AbstractBackgroundPain in the orofacial region is often reported after whiplash trauma. However, prospective studies evaluating clinical signs related to orofacial pain and disability in whiplash populations are rare. The aim of the present study was to evaluate clinical signs related to pain and dysfunction in orofacial and neck regions after whiplash trauma, in a short‐ and long‐term perspective.MethodsIn total, 84 cases (48 women) diagnosed with neck distortion after a car accident and 116 controls (68 women) were examined within 1 month, and 49 cases (27 women) and 71 controls (41 women) were re‐examined 2 years later. Outcome measures were pain on palpation of jaw and neck muscles and maximal jaw opening. Analysis was performed using mixed‐models.ResultsCases and women were at higher risk for pain on palpation of jaw muscles (OR:7.7; p < 0.001 and OR:3.2; p = 0.010 respectively) and neck muscles (OR:12.7; p < 0.001 and OR:2.9; p = 0.020 respectively) but with no significant effect of time. Cases and women also had lower maximal jaw opening (−3.1; p = 0.001 and −3.3; p = 0.001 respectively). There was no significant time effect, but a significant interaction between cases and time (2.2; p = 0.004).ConclusionIndividuals with a whiplash trauma present a higher risk for pain on palpation in jaw and neck muscles both in a short‐ and long‐term perspective, but show normal jaw movements. No time effect suggests that cases do not spontaneously improve nor get worse. Investigating pain on palpation in the jaw and neck muscles after whiplash trauma can identify individuals at risk for developing long‐term orofacial pain and dysfunction.SignificanceOrofacial pain is often reported after whiplash trauma but most previous studies concerning orofacial pain in whiplash populations have been questionnaire studies. Cases with a previous whiplash trauma and women, in general, had higher risk for pain on palpation in the jaw and neck region. Investigating pain on palpation after a whiplash trauma can help to identify individuals at risk of developing long‐lasting pain in the orofacial region.