bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravaskuläre Therapieverfahren zu lokoregionalen Therapien von Lungentumoren
Authors: Vogl Thomas J. , Mekkawy Ahmed , Thabet Duaa B. 
Published: August 2023

Hintergrund Die Inzidenz von Lungenkarzinomen hat im letzten Jahrhundert stark zugenommen. Darüber hinaus ist die Lunge der häufigste Ort der Metastasierung. Trotz der verbesserten Diagnostik und Therapie von Lungenmalignomen ist die Prognose der Patienten noch immer unbefriedigend. Lokoregionäre chemotherapeutische Techniken zur Behandlung von Lungenmalignomen haben heutzutage die Aufmerksamkeit der Forschung auf sich gezogen. Ziel dieses Übersichtsartikels ist es, verschiedene lokoregionale intravaskuläre Techniken und deren Behandlungsprinzipien vorzustellen und die jeweiligen Vor- und Nachteile als palliative und neoadjuvante Behandlungsmethode bei der Behandlung von Lungenmalignomen zu evaluieren.
Methode Die verschiedenen Verfahren bei der Behandlung von Lungenmalignomen wie isolierte Lungenperfusion (ILP), selektive pulmonale Arterienperfusion (SPAP), transpulmonale Chemoembolisation (TPCE), Bronchialarterieninfusion (BAI), Bronchialarterienchemoembolisation (BACE) und intraarterielle Chemoperfusion (IACP) werden vergleichend bewertet.
Ergebnisse Lokoregionale intravaskuläre Chemotherapieverfahren erweisen sich als vielversprechende Behandlungsoptionen bei der Behandlung von malignen Lungentumoren. Um optimale Ergebnisse zu erreichen, sollte mittels lokoregionaler Technik eine möglichst hohe Aufnahme des Chemotherapeutikums in das Zielgewebe mit schneller systemischer Clearance erzielt werden.
Schlussfolgerung Unter den verschiedenen Behandlungsoptionen bei Lungenmalignomen ist die TPCE das am besten evaluierte Behandlungskonzept. Allerdings sind weitere Studien nötig, um das optimale Behandlungskonzept mit den besten klinischen Ergebnissen zu definieren.
Kernaussagen
Zitierweise
Significant Variability in Postoperative Thromboprophylaxis in Cushing's Disease Patients: A Survey of the North American Skull Base Society and the AANS/CNS Joint Tumor Section
Authors: White Alexandra J. , Almeida João Paulo , Petitt Jordan C. , Yogi-Morren Divya , Recinos Pablo F. , Kshettry Varun R. 
Published: August 2023

Abstract
Introduction Cushing's disease (CD) is associated with hypercoagulability which is associated with an increased risk of venous thromboembolic events (VTEs) perioperatively. This risk persists even after successful transsphenoidal surgery (TSS). However, there are no current guidelines for pharmacologic thromboprophylaxis in this patient population.
Objective Characterize existing thromboprophylaxis management practices in patients undergoing TSS for CD.
Methods An anonymous RedCap survey comprised of questions about perioperative thromboprophylaxis in CD patients was distributed via the American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Joint Tumor Section and the North American Skull Base Society (NASBS) email lists.
Results The survey was distributed to 554 members of the AANS/CNS Joint Tumor Section and 1,094 members of NASBS asking that members who surgically treat CD respond. Sixty responses (3.0% response rate) were received. Fifty-two (86.7%) respondents are involved in the postoperative management of CD patients. Thirty-six (69.2%) treat all patients with postoperative VTE chemoprophylaxis, 8 (15.4%) treat some patients, while 8 (15.4%) do not use chemoprophylaxis. Preferred chemoprophylaxis varies as 26 (59.1%) administer low molecular weight heparin, 14 (31.8%) give unfractionated heparin, 1 (2.3%) give direct oral anticoagulants, and 3 (6.8%) give aspirin. Most (28, 53.8%) of the respondents perceive the VTE risk in this patient population to be 0 to 5%, 16 (30.8%) perceive the risk to be 6 to 10%, and 8 (15.4%) perceive it to be 11 to 20%.
Conclusion There is great variability in VTE detection and postoperative prevention practice patterns in CD patients. This study highlights the need for prospective studies to clarify optimal pharmacologic chemoprophylaxis strategies and duration in this patient population.
Anticoagulation with Intravenous Direct Thrombin Inhibitors in Pediatric Extracorporeal Membrane Oxygenation: A Systematic Review of the Literature
Authors: Kiskaddon Amy L. , Do Nhue L. , Williams Pamela , Betensky Marisol , Goldenberg Neil A. 
Published: August 2023

AbstractAlthough intravenous (IV) direct thrombin inhibitors (DTI) have gained interest in pediatric extracorporeal membrane oxygenation (ECMO), dosing and safety information is limited. The objective of this systematic review was to characterize DTI types, dosing, monitoring, and outcomes (bleeding and thromboembolic) in pediatric ECMO patients managed with IV DTIs. We conducted searches of MEDLINE (Ovid) and Embase (Elsevier) from inception through December 2022. Case reports, retrospective studies, and prospective studies providing per-patients or summary data for patient(s) <18 years of age receiving IV DTI for ECMO anticoagulation were included. Study selection and data extraction were conducted independently by two reviewers. A total of 28 studies: 14 case reports, 13 retrospective studies, and 1 prospective study were included, totaling 329 patients. Bivalirudin was utilized in 318 (96.7%), argatroban in 9 (2.7%), and lepirudin in 2 (0.6%) patients. Infusion dosing included: bivalirudin 0.14 ± 0.37 mg/kg/h, argatroban 0.69 ± 0.73 µg/kg/min, lepirudin 0.14 ± 0.02 mg/kg/h. Laboratory monitoring tests utilized were the activated clotting time, activated partial thromboplastin time (aPTT), diluted thrombin time, and thromboelastography measures. The aPTT was utilized in most patients (95%). Thromboembolism, bleeding, or death were observed in 17%, 17%, and 23% of bivalirudin, argatroban, and lepirudin patients, respectively. Bivalirudin appears to be the most frequently used DTI in pediatric ECMO. Dosing and laboratory monitoring varied, and bleeding and thromboembolic events were reported in 17% of patients. Prospective studies are warranted to establish dosing, monitoring, safety, and efficacy of bivalirudin and other IV DTI in pediatric ECMO.
Unraveling the strain-induced and spin–orbit coupling effect of novel inorganic halide perovskites of Ca3AsI3 using DFT
Authors: Rahman Md. Ferdous , Rahman Md. Azizur , Islam Md. Rasidul , Ghosh Avijit , Bashar Shanto Md. Abul , Chowdhury Mithun , Al Ijajul Islam Md. , Rahman Md. Hafizur , Hossain M. Khalid , Islam M. A. 
Published: August 2023

Recently, inorganic perovskite materials have been attracting increasing attention owing to their exceptional structural, electronic, and optical characteristics in photovoltaic technology. Ca3AsI3 is a semiconductor material that shares similarities with the group of inorganic metal halide perovskites. Ca3AsI3 possesses a perovskite crystal structure that is cubic, which is classified under the space group Pm-3m (no. 221). Our research aims to analyze how the optical and electronic properties of Ca3AsI3 are influenced by spin–orbit coupling (SOC) and strain using the first-principles density-functional theory. The inorganic Ca3AsI3 perovskite has an electronic band structure that possesses a direct bandgap of roughly 1.58 eV at the Γ(gamma)-point. However, when the SOC relativistic effect is introduced, this value decreases to around 1.27 eV. As the level of compressive strain is increased, the bandgap becomes narrower, whereas with increasing tensile strain, the bandgap becomes wider. It has been observed through analysis of the dielectric functions, absorption coefficient, and electron loss function of these materials that the optical properties give Ca3AsI3 the ability to effectively absorb visible light. According to the study, the dielectric constant peaks of Ca3AsI3 shift toward a lower photon energy (redshift) as the level of compressive strain increases. On the other hand, when subjected to increased tensile strain, these peaks have a tendency to shift toward a higher photon energy (blueshift), as per the same study. Modifying the energy gap of Ca3AsI3 perovskites to suit optoelectronic and solar cell needs could be achieved by using techniques involving the SOC effect and by applying strain. These approaches have the potential to enable utilization of Ca3AsI3 in such applications in the future.
Outlier or handover: outcomes for General Medicine inpatients
Authors: Thompkins S. , Schaefer S. , Toh D. , Horwood C. , Thompson C. H. 
Published: August 2023

Objective Patients admitted from the emergency department may be co-located on the treating team’s ‘home ward’. If no bed is available, patients may be sent to another ward, where they may remain under the admitting team as an ‘outlier’. Conversely, care may be handed over to the team on whose home ward they are located. We conducted a retrospective analysis to understand the impact of outlier status and handovers of care on outcomes for General Medicine inpatients. Methods General Medicine admissions at the Royal Adelaide Hospital between September 2020 and November 2021 were analysed. We examined the rate of hospital-acquired complications, inpatient mortality rate, mortality within 48 h of admission, Relative Stay Index, time of discharge from hospital and rate of adverse events within 28 days of discharge. Results A total of 3109 admissions were analysed. Handovers within 24 h of admission were associated with a longer length of stay. There was a trend towards higher rates of adverse events within 28 days of discharge with handovers of care. Outlier status did not affect any outcome measures. Conclusions Handovers within the first 24 h of admission are associated with longer than expected length of stay.
Effect of Pinus densiflora bark extract supplementation in broiler diet on antioxidative status, nutrient digestibility, and intestinal barrier function
Authors: Kim Kum-Chol , Ri Sung-Hyok , Jong Song-Il , Sin Jo-Il , Ju Chol-Ho , Pak Song-Sik , Ri Ju-Hua 
Published: August 2023

Context Pinus densiflora bark extract (PBE) has attracted more attention in the livestock industry due to its antioxidant activity, antibacterial activity and beneficial nutrient utilisation. Aims This study aimed to determine the effect of dietary PBE concentration on growth performance, antioxidant activity, nutrient digestibility and intestinal health in broilers. Methods In total, 180 1-day-old Arbour Acres male broilers were randomly divided into four treatment groups (0, 100, 200, 300 mg/kg PBE respectively), with five replicates per group and nine broilers per replicate, and the treatments were applied for 42 days. Results Dietary PBE supplementation improved significantly antioxidative status and gene expression of antioxidant enzymes such as SOD1, GPx1 and CAT in broilers. Moreover, PBE supplementation increased the intestinal absorption and mRNA expression level of the tight junction proteins. In addition, the diet supplemented with PBE significantly increased the villus height (P < 0.01) and the villus:crypt ratio (C:V) (P < 0.05) in jejunum. Although supplementation of 300 mg/kg PBE significantly decreased nutrient digestibility and activities of lipase and amylase (P < 0.05), supplementation of 200 mg/kg PBE had no negative impact on digestibility. Conclusion This study showed that supplementation of 200 mg/kg PBE improves the antioxidant status and the intestinal health without adverse impact in broilers. Implications This study has provided scientific insight and rationale to protect broilers from oxidative stress and intestinal disease.
Effect of soil treatment on the growth and foliage chemistry of three Eucalyptus species grown in a plantation as a food source for koalas
Authors: Cochrane Teresa , Krebs Gaye L. , McManus Scott , Castle Scott , Spooner Peter G. 
Published: August 2023

Koalas in captivity are often provided with food from purpose-grown eucalypt plantations. In this study the growth/establishment of a long-term koala food plantation and the foliage chemistry of three Eucalyptus species (Eucalyptus microcorys, E. propinqua and E. tereticornis) that had applications of soil treatments (Terracottem™, mycorrhiza or a combination of both, and a control) at the time of planting were investigated. As well as tree growth, the foliage chemistry measured included total nitrogen (N), available N, ash, and moisture contents, and dry matter digestibility. Shortly after planting, the soil treatments had significant effects on tree growth but after approximately 2.5 years, they did not impact either tree growth or foliage chemistry. However, foliage age affected foliage chemistry, with new foliage having higher moisture and total N concentrations and lower ash contents than mature foliage. There were significant differences in tree growth and foliage chemistry between replicate blocks, which may have been related to environmental or geographical variables. This research provided critical information concerning the establishment of a suitable feed source for captive koalas and, more generally, furthered knowledge of Eucalyptus foliage chemistry. Future studies should investigate impacts of soil treatments on plant secondary metabolites including formylated phloroglucinol compounds. Understanding dietary selection is an important consideration when selecting species and managing food plantations for koalas. Providing captive koalas with a variety of different Eucalyptus species and foliage maturity ensures that they can select species and nutrients that they require.
Policy facilitators and barriers to the implementation of the ‘One Health’ approach in India: Placing One Health at the heart of COVID-19 recovery and beyond
Authors: Aneja Kashish , Padhy Rituparna , Halabi Sam 
Published: August 2023

Abstract
The COVID-19 pandemic has underscored the necessity of adopting an integrated approach towards sustainably balancing the health of people, animals and ecosystems by promoting One Health. The authors analyse the legal and regulatory frameworks in India for their existing and future capacity to accommodate One Health-based policies. India has adopted several action plans, initiated multiple cross-ministry projects, and established institutional bodies during the COVID-19 pandemic to promote One Health. However, many of these were implemented piecemeal due to the federal structure in the country and the lack of adequate sustained inter-ministerial collaboration. The prevalent overtones of anthropocentric bias in the existing laws and policies adversely affect the potential of an effective One Health framework in the country as well. The authors highlight future considerations for India for placing One Health at the centre of legislation and policy making, and recommend both short-term and long-term measures that ought to be considered.

One Health impact statement
This article is an invited review article that illustrates how India is strategically placed for incorporating One Health in its policy making for pandemic preparedness and beyond. It underscores the urgency of examining certain future considerations for developing effective One Health-based governance and regulatory frameworks in the country.
Holographic entanglement entropy with Power-Maxwell electrodynamics in higher dimensional AdS black hole spacetime*
Authors: Wang 王 Kongchen 孔辰 , Zhang 张 Wanhe 万贺 , Yao 姚 Weiping 伟平 
Published: August 2023

Abstract
We investigate the behaviors of the scalar operator and holographic entanglement entropy in the metal/superconductor phase transition with Power-Maxwell electrodynamics in a higher dimensional background away from the probe limit. We observe that the larger parameters b and q make the condensation of the scalar operator more difficult, and the critical temperature decreases more slowly as the factors increase. In the belt geometry, the value of the entanglement entropy in the metal and superconductor phases is not only related to the the strength of the Power-Maxwell field but also to the width of the strip geometry. At the phase transition point, the discontinuous slope of entanglement entropy is universal for different model factors. It turns out that holographic entanglement entropy is a powerful tool to probe the properties of the phase transition in this holographic superconductor model.
Potential impacts of land use change on streamflow and groundwater resources under changing climate in the Flint River Basin, Georgia, United States
Authors: Huang Yu-Kai , Dwivedi Puneet , Karki Ritesh , Kalin Latif 
Published: August 2023

Abstract
This study ascertains the factors affecting streamflow and irrigation water demand under different land use/cover (LULC) changes and future climate scenarios in the Flint River Basin, Georgia, United States, using the seemingly unrelated regression (SUR) panel model. An advantage of using the SUR model is that it accounts for cross-hydrological correlation, which is important due to the cross-sectional dependence between streamflow and pumpages. A set of streamflow, ground/surface water withdrawal, climatic, and LULC data used in this study was gathered from publicly available data sources and state agencies. Furthermore, the results show that a 10% increase in corn acreage in the watershed could lead to a significant rise in surface water and groundwater pumpings demands, respectively at 124% and 168%. This study identifies potential evapotranspiration (PET) threshold, which may lead to a water deficit in the region. For various LULC scenarios involving corn and urban area expansion, the probability of facing water scarcity at least once from 2025 to 2060 is estimated to range from 0.2% to 3.8% and 0.7% to 2.6% under RCP 4.5 and RCP 8.5 scenarios, respectively. These findings underscore the trade-off between water scarcity and food security in the context of changing climate, highlighting a need to design appropriate incentives to enhance water-use efficiency and adopt climate-smart strategies. The study’s significance extends to other similar watersheds worldwide that face similar challenges arising from changing land use and climate, which impact the sustainability of water resources, particularly groundwater resources, over time.
Influence of a powder-forming additive on the physical-mechanical properties and structure of a ceramic material
Authors: Montayev Sarsenbek A , Narikov Kanat A , Shakeshev Bekbulat T , Taudaeva Ainur A , Dosov Karzhaubai Zh 
Published: August 2023

Abstract
The purpose of the study was to explore the effect of various pore-forming additives on the porosity and permeability of alumina ceramic material. Analysis of mineralogical, particle size distribution and chemical composition of raw materials and ceramics samples was performed using standard research methods, JCM-6000 (JEOL) and field emission scanning electron microscopy (FESEM) microscopes, LW600LT, x-ray diffractometer Rigaku D/max-RA, Hitachi SU-70 and Pore Master. The microstructure of the composite ceramic material in all experiments demonstrated the presence of numerous cross-sectionally elongated pores, which proves the dependence of the pore-forming structure on the shape of the pore-forming agent. The high permeability of samples with lignin is due to the improved plastic properties of the clays. By increasing the clay content from 5 to 10 wt.% it was possible to increase the sintering density of the samples and reduce their overall porosity. The permeability porosity increases with the introduction of more urea, and the strength of the samples is then at its maximum. Samples with the addition of lignin demonstrated resistance to mechanical stress and high permeability. The study identifies the prospects of using crystallised urea and lignin from manufacturing waste as a pore former, which will allow the establishment of environmentally friendly ceramic materials with high permeability and durability and solve the problem of atmospheric pollution.
Temperature field model in surface grinding: a comparative assessment
Authors: Yang Min , Kong Ming , Li Changhe , Long Yunze , Zhang Yanbin , Sharma Shubham , Li Runze , Gao Teng , Liu Mingzheng , Cui Xin , Wang Xiaoming , Ma Xiao , Yang Yuying 
Published: August 2023

Abstract
Grinding is a crucial process in machining workpieces because it plays a vital role in achieving the desired precision and surface quality. However, a significant technical challenge in grinding is the potential increase in temperature due to high specific energy, which can lead to surface thermal damage. Therefore, ensuring control over the surface integrity of workpieces during grinding becomes a critical concern. This necessitates the development of temperature field models that consider various parameters, such as workpiece materials, grinding wheels, grinding parameters, cooling methods, and media, to guide industrial production. This study thoroughly analyzes and summarizes grinding temperature field models. First, the theory of the grinding temperature field is investigated, classifying it into traditional models based on a continuous belt heat source and those based on a discrete heat source, depending on whether the heat source is uniform and continuous. Through this examination, a more accurate grinding temperature model that closely aligns with practical grinding conditions is derived. Subsequently, various grinding thermal models are summarized, including models for the heat source distribution, energy distribution proportional coefficient, and convective heat transfer coefficient. Through comprehensive research, the most widely recognized, utilized, and accurate model for each category is identified. The application of these grinding thermal models is reviewed, shedding light on the governing laws that dictate the influence of the heat source distribution, heat distribution, and convective heat transfer in the grinding arc zone on the grinding temperature field. Finally, considering the current issues in the field of grinding temperature, potential future research directions are proposed. The aim of this study is to provide theoretical guidance and technical support for predicting workpiece temperature and improving surface integrity.
EIEPCF: accurate inference of functional gene regulatory networks by eliminating indirect effects from confounding factors
Authors: Peng Huixiang , Xu Jing , Liu Kangchen , Liu Fang , Zhang Aidi , Zhang Xiujun 
Published: August 2023

Abstract
Reconstructing functional gene regulatory networks (GRNs) is a primary prerequisite for understanding pathogenic mechanisms and curing diseases in animals, and it also provides an important foundation for cultivating vegetable and fruit varieties that are resistant to diseases and corrosion in plants. Many computational methods have been developed to infer GRNs, but most of the regulatory relationships between genes obtained by these methods are biased. Eliminating indirect effects in GRNs remains a significant challenge for researchers. In this work, we propose a novel approach for inferring functional GRNs, named EIEPCF (eliminating indirect effects produced by confounding factors), which eliminates indirect effects caused by confounding factors. This method eliminates the influence of confounding factors on regulatory factors and target genes by measuring the similarity between their residuals. The validation results of the EIEPCF method on simulation studies, the gold-standard networks provided by the DREAM3 Challenge and the real gene networks of Escherichia coli demonstrate that it achieves significantly higher accuracy compared to other popular computational methods for inferring GRNs. As a case study, we utilized the EIEPCF method to reconstruct the cold-resistant specific GRN from gene expression data of cold-resistant in Arabidopsis thaliana. The source code and data are available at https://github.com/zhanglab-wbgcas/EIEPCF.