bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silent victims: Negative effects of observing workplace deviance on employees’ emotional exhaustion and workplace thriving
Authors: Arshad Mamoona , Malik Muhammad Abdur Rahman , Hussain Shoaib Amjad 
Published: May 2023

Building on previous studies on third-party observations (TPOs) of mistreatments, in this study, we investigate the effects of TPO of workplace deviance (TPO-WD). Drawing on conservation of resource theory, we explore the intermediary process through which TPO-WD, influences employees’ workplace thriving. Using multi-wave data from 346 employees, our results suggest that those who observe, or hear about, incidents of workplace deviance experience a heightened level of emotional exhaustion, which has a detrimental impact on workplace thriving. Furthermore, we also test how these relationships are impacted by the extent of employees’ organizational identification and a cooperative psychological climate. These findings not only provide a resource-based view on how TPO-WD affects workplace thriving but also highlight the critical importance of cooperative psychological climate as a resource passageway to prevent damaging employees’ workplace thriving. JEL Classification: L2 Firm Objectives, Organization, and Behaviour
“ActuaYa”: A Preliminary Efficacy Study of a Chronic Disease Prevention and Health Promotion Intervention for Older Hispanic Women
Authors: Cianelli Rosina , De Oliveira Giovanna , Villegas Natalia , Toledo Christine , De Santis Joseph , Iriarte Evelyn , Baeza Maria Jose , Thomas Sophia , Montano Nilda Peragallo 
Published: May 2023

Chronic diseases (CDs) are increasingly common among the aging population. Some evidence suggests that older Hispanic women ages 50 years and older (OHW) are at an increased risk for CDs and poorer outcomes than other groups. This study investigated the preliminary efficacy of ActuaYa, a culturally tailored CD prevention and health promotion intervention for OHW. A prospective, single-group, repeated measures study ( n = 50) was conducted in Florida. Clinical measures and surveys were collected at baseline and post-intervention at 3- and 6-month follow-up. Descriptive statistics, paired-sample t-tests, and McNemar tests were used for analysis. At baseline, more than half of the participants had a CD. Post-intervention results showed a significant decrease in participants’ MAP, BMI, and A1C, and a significant increase in self-efficacy for exercise and HIV knowledge compared to baseline measures. The results of this study support the preliminary efficacy of ActuaYa in preventing CDs and increasing health promotion among OHW.
Extemporaneous compounding of dabrafenib and trametinib for cancer patients with feeding tubes
Authors: Bui Trinh , Vu Van , Luon Darren 
Published: May 2023

Introduction Dabrafenib and trametinib are oral targeted agents indicated for BRAF mutated non-small cell lung cancer and melanoma. There is little data to support the administration of these two agents via enteral feeding tube. This case series describes three patients who received compounded dabrafenib and trametinib suspensions through enteral feeding tubes. Case report We present three patients who required dabrafenib and trametinib to be prepared as a non-standard compound for the medications to be administered via feeding tube. The patients were diagnosed with with BRAF mutated cancers including melanoma, non-small-cell lung carcinoma, and anaplastic thyroid cancer. In all three cases, there was evidence of initial disease response on imaging, and there were no unexpected toxicities secondary to dabrafenib and trametinib. Discussion There are patients that are unable to tolerate medications by mouth due to dysphagia, anatomical malfunctions, or other digestive disorders. There is limited literature that describes preparation of trametinib and dabrafenib into an enteral suspension. Identifying a safe and efficacious method of administering these two medications via feeding tube ensures that these patients continue to be able to receive them as part of their anti-cancer therapy. Conclusion Despite the lack of available data, compounding of dabrafenib and trametinib may be clinically appropriate when benefits outweigh the risk of unconventional administration. Further studies are warranted to assess for the pharmacokinetics, pharmacodynamics, stability, and storage for these liquid medications.
Reversible control of reproduction in tom cats: medical options for manipulating libido and fertility
Authors: Ferré-Dolcet Lluis , Romagnoli Stefano 
Published: May 2023

Background: There has been a growing interest in alternatives to surgery for controlling reproduction in tom cats, and the resultant medical options add to a practitioner’s toolbox when handling these cases in clinical practice. It is important, however, that when suggesting these drugs, veterinarians have a good understanding of their mode of action, and their correct use and dosage. Clinical relevance: Breeders increasingly wish to be able to switch on/off the reproductive ability of their tom cats in a controlled manner. In addition, in small animal medicine, there has been concern from some academics, and a growing number of pet cat owners, about potential long-term effects of surgical sterilisation. Further, for some cats surgical castration may not be possible due to health conditions that mean anaesthesia is unsafe. In all of these scenarios, medical alternatives to surgery can prove useful. Equipment and technical skills: No special equipment or technical skills are required. A good knowledge of the medical alternatives to surgical sterilisation for controlling reproduction in a tom, and making sure the patient is a suitable candidate, are, however, important for ensuring the cat’s health during and after treatment and the owner’s satisfaction. Audience: This review is aimed principally (but not exclusively) at veterinary practitioners working with cat breeders who seek a temporary arrest in their tom cat’s reproduction. It may also help practitioners with clients who would like an alternative to surgery or with cats where anaesthesia for surgical castration is not possible. Evidence base: Advances in reproductive feline medicine have resulted in improved knowledge of medical contraception. This review draws on scientific evidence-based papers that report on the mode of action, length of efficacy and potential side effects of different methods of medical contraception, as well as the authors’ own clinical experience.
The Simple View of borrowing and code-switching
Authors: Treffers-Daller Jeanine 
Published: May 2023

Aims and Objectives: In this paper, a novel approach to the distinction between borrowing and code-switching is proposed, called the Simple View of borrowing and code-switching. Under this view, listedness is seen as the key condition for classifying words or multiword units (MWUs) as borrowings. For MWUs, listedness is operationalized with mutual information (MI) scores: the higher the MI score of a given set of words, the higher the likelihood it is listed in the lexicon. Under the Simple View, the distinction between borrowing and code-switching is seen as a specific instantiation of the distinction between what belongs in the lexicon (fixed, arbitrary patterns) and what is computed online (productive rules), and should therefore be considered as part of the grammar. Methodology: Assumptions from the Simple View were tested on a corpus of switches of single words and MWUs from a Turkish-German code-switching corpus (87,000 words), which was transcribed in CHAT format. Data and analysis: The frequency of switches in either direction, and their morphosyntactic integration patterns were analysed with CLAN. The formulaicity of the MWUs was analysed with MI scores through Sketchengine. Findings: The MI scores of the donor language MWUs were found to be above 3, which is the cut-off point for formulaicity in Corpus Linguistics. Thus, the MWUs were found to be borrowings. In addition, MWUs were found to be more likely to be borrowed than single words. Originality: Insights about formulaic language from Corpus Linguistics and Second Language Acquisition were used to inform analyses of language contact phenomena, and new ways to test the model are proposed. Significance: The Simple View offers a unified approach to borrowing of lexical items and function words and opens a new avenue for research using neuroscientific methods to test whether items are listed in speakers’ mental lexicons.
Patients with Lower Positive Lymph Nodes Ratio May Benefit from Preoperative Radiotherapy in Stage III Non-Small Cell Lung Cancer
Authors: Wang Ruiyang , Shang Shijie , Huang Xinyi , Nie Yu , Wang Fei , Yu Jinming , Chen Dawei 
Published: May 2023

Background Although preoperative radiotherapy (PORT) is a promising therapeutic option for stage III non-small cell lung cancer (NSCLC), the efficacy of this treatment remains controversial. The positive lymph node ratio (PLNR) is recognized as an independent prognostic factor for survival. However, no previous studies have focused on the association between PLNR and PORT in stage III NSCLC. Methods Data were collected from the Surveillance, Epidemiology and End Results (SEER) database, and all patients enrolled in this analysis were diagnosed during 2010–2015. The primary endpoint was overall survival (OS). Univariate and multivariate Cox regression analysis was used to identify factors associated with survival before and after case-control matching. PLNR was defined as the ratio of the number of positive lymph nodes to the total number of retrieved or examined lymph nodes. A cutoff value for PLNR was calculated using an X-tile model. Results Overall, 391 patients with PORT and 2814 patients without PORT were enrolled in this study. The cohort after 1:1 case-control matching included 322 patients who received PORT and 322 patients without PORT. PORT was not associated with a significant effect on OS (HR  =  1.14; 95% CI: 0.91–1.43; P  =  0.825). Multivariate Cox regression analysis showed that PLNR ( P < 0.001) was independently associated with OS in patients with stage III NSCLC. An X-tile model was used to identify a cutoff value for PLNR: the risk of death was significantly lower in patients with PLNR ≤0.41 who received PORT than in those with PLNR >0.41 who received PORT (HR  =  0.59; 95% CI: 0.38–0.91; P  =  0.015). Conclusion PLNR may be a prognostic factor for survival in patients with stage III NSCLC who undergo PORT. Lower PLNR is a predictor of better OS and thus warrants further study.
COVID-19 complicating pregnancy: A retrospective study of nine intensive care unit patients
Authors: Sivalingam Deepak , Ajith Kumar AK , Shashank MR , Murthy Pooja R , Venkatesha Gupta KV 
Published: May 2023

Background With the emergence of the coronavirus 2019 (COVID-19) pandemic, it was essential to determine the impact of this disease on pregnant women and neonatal outcomes. In this study, we present a series of nine cases of pregnant women with COVID-19 disease requiring intensive care unit (ICU) admission. Methods We retrospectively collected clinical data of pregnant women with COVID-19 disease admitted to ICU between September 2020 and September 2021. Results Most common presenting symptom was cough. Two patients had no respiratory symptoms at presentation. Five of the nine patients required invasive mechanical ventilation. Seven patients required caesarean section, four of whom delivered preterm. There were no maternal or neonatal deaths. Conclusions Although maternal and neonatal outcomes reported in our study are encouraging, it is imperative to emphasize the importance of an individualized, multidisciplinary approach, and good healthcare infrastructure for optimal management of this group of patients.
Designing for Family Engagement in Neonatal ICUs: How Is the Interior Design of Single-Family Rooms Supporting Family Behaviors, From Passive to Active?
Authors: Machry Herminia , Joseph Anjali , White Robert , Allison David 
Published: May 2023

Purpose: Understand how the interior design of single-family rooms (SFRs) in neonatal intensive care units (NICUs) can support family engagement behaviors. Background: Family members are integral contributors to infant care in NICUs, impacting infant development. While at the NICU, parents are encouraged to participate in a process called family engagement, where they are expected to move from passive to active caregivers, in preparation for their role after discharge. While family engagement is affected by the built environment, no studies have investigated this relationship in any depth. NICU settings morphed to involve families through the SFR design model, but the interior environment of SFRs have not been sufficiently explored as a resource to support specific family engagement behaviors. Methods: We interviewed family and staff and observed family engagement behaviors in SFRs at two NICUs. Behaviors were observed and described in terms of their location, number of people, and design elements involved. Built environment characteristics were collected through physical assessments, and interviews elicited participants’ perceptions about design factors impacting family behaviors inside SFRs. Data analysis followed grounded theory segments and pattern matching. Results: Three behavioral patterns and five themes were identified showing how SFRs’ private bathrooms, family storage, family zone partitions, positive distractions, and information boards can support families’ home-like, educational, collaborative, and infant care behaviors. Conclusions: The interior design of SFRs can be a resource to family engagement in the NICU. Future research should operationalize SFR features found in our study to measure and validate their impact on family engagement outcomes.
Anonymization of whole slide images in histopathology for research and education
Authors: Bisson Tom , Franz Michael , Dogan O Isil , Romberg Daniel , Jansen Christoph , Hufnagl Peter , Zerbe Norman 
Published: May 2023

Objective The exchange of health-related data is subject to regional laws and regulations, such as the General Data Protection Regulation (GDPR) in the EU or the Health Insurance Portability and Accountability Act (HIPAA) in the United States, resulting in non-trivial challenges for researchers and educators when working with these data. In pathology, the digitization of diagnostic tissue samples inevitably generates identifying data that can consist of sensitive but also acquisition-related information stored in vendor-specific file formats. Distribution and off-clinical use of these Whole Slide Images (WSIs) are usually done in these formats, as an industry-wide standardization such as DICOM is yet only tentatively adopted and slide scanner vendors currently do not provide anonymization functionality. Methods We developed a guideline for the proper handling of histopathological image data particularly for research and education with regard to the GDPR. In this context, we evaluated existing anonymization methods and examined proprietary format specifications to identify all sensitive information for the most common WSI formats. This work results in a software library that enables GDPR-compliant anonymization of WSIs while preserving the native formats. Results Based on the analysis of proprietary formats, all occurrences of sensitive information were identified for file formats frequently used in clinical routine, and finally, an open-source programming library with an executable CLI tool and wrappers for different programming languages was developed. Conclusions Our analysis showed that there is no straightforward software solution to anonymize WSIs in a GDPR-compliant way while maintaining the data format. We closed this gap with our extensible open-source library that works instantaneously and offline.
Association of ANRIL Gene Single-Nucleotide Polymorphisms With Allergic Rhinitis in Kurdish Population From Kermanshah, Iran
Authors: Falahi Sara , Feizolahi Parisa , Monshizadeh Ali , Mahmoudi Zahra , Mahdavi Jila , Salari Farhad , Karaji Ali Gorgin , Rezaiemanesh Alireza 
Published: May 2023

Background Allergic rhinitis (AR) is the most common inflammatory disorder of the upper airway caused by aberrant immune responses to allergens in genetically predisposed individuals. Recently, the long noncoding RNA (lncRNA) antisense noncoding RNA in the INK4 locus (ANRIL) has been identified as a novel genetic factor associated with increased AR risk. Objectives This study aimed to evaluate the potential correlation of ANRIL gene single nucleotide polymorphisms (SNPs) with AR risk in the Kurdish population of Kermanshah, Iran. Methods In this case–control study, 130 AR patients and 130 healthy controls were recruited to genotype for two SNPs of the ANRIL gene (rs1333048 and rs10757278) using the Tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR) method. Results Our results showed no significant difference for the alleles and genotypes frequency distribution of lncRNA ANRIL SNPs (rs1333048 and rs10757278) between AR patients and healthy controls ( p > 0.05). Additionally, the dominant, additive and recessive genetic models of both SNPs were not associated with altered susceptibility to AR risk ( p > 0.05). Conclusion The results demonstrated that the ANRIL gene rs1333048 and rs10757278 polymorphisms might not be associated with susceptibility to AR in the Kurdish population of Kermanshah, Iran
Complete androgen insensitivity syndrome with Sertoli cell tumour in a 27-year-old married woman: a case report
Authors: Rasheed Mumini Wemimo , Idowu Najeem Adedamola , Adekunle Adebayo Ayoade , Olarewaju Joseph Olusola , Oduola-owoo Latifat Tunrayo , Odetayo Foluke Omolara , Omolade Felix Abiodun , Opeyemi Akinremi Tosin 
Published: May 2023

Abstract
Background
Androgen insensitivity syndrome is a rare X-linked disorder of sex development that results from mutations in the androgen receptors leading to failure of normal masculinization of the external genitalia in genetically male individuals. Our aim was to report this rare case of complete androgen insensitivity syndrome with Sertoli cell tumour, and our objective was to relate our experience on the challenges of the case and its successful management of the case.

Case presentation
We report a case of a 27-year-old married Nigerian woman who presented at the surgical outpatient of our centre with a complaint of primary amenorrhea. She had an attendant history of coital difficulty following marriage. Clinical examination revealed a female phenotype with left groin swelling. A diagnosis of complete androgen insensitivity syndrome was made following hormonal evaluation, advanced imaging studies, karyotyping, and cytogenetic study. She and her parents including her husband were duly counselled on the natural history and principles of treatment of this clinical condition. She subsequently had a bilateral orchidectomy, and she was placed on oestrogen replacement therapy as well as serial vaginal dilation. The outcome was satisfactory.

Conclusion
We reported a rare case of complete androgen insensitivity syndrome in a married woman. We documented our experience with successful conservative vaginal dilatation, which allowed satisfactory vaginal sexual intercourse.
The effect of addition of magnesium sulfate or dexamethasone to bupivacaine on the post-operative analgesic duration of ultrasound-guided quadratus lumborum block in open abdominal surgeries: a comparative study
Authors: Samir Ghada M. , Aboulella Sahar K. , Moussa Moussa E. , Saleh Mohamed A. 
Published: May 2023

Abstract
Background
The aim of this study was to assess the effect of addition of 500-mg magnesium sulfate (MgSo4) or 8-mg dexamethasone to bupivacaine in bilateral ultrasound-guided quadratus lumborum block (QLB), on the duration of post-operative analgesia, the patient’s hemodynamic parameters, the severity of post-operative pain, number of patients who required rescue analgesia, the total dose of pethidine given, the number of patients who maintained post-operative analgesia for 36 h, and the time to first ambulation. Sixty-six patients, 18 to 65 years old, with body weight 60–90 kg, scheduled to undergo elective open abdominal surgeries under general anesthesia, were randomly divided into three equal groups: the Bupivacaine-Magnesium QLB group (BM) patients, the Bupivacaine-Dexamethasone QLB group (BD) patients, and the Bupivacaine-Saline QLB group (BS) patients.

Results
The post-operative visual analogue scale (VAS) at rest and with movement was comparable between patients in the three groups: upon arrival to the post-operative care unit (PACU), in the PACU, and in the post-operative 2, 4, 6, 8, 12, 24, and 36 h. At 30 post-operative hours, the VAS at rest and with movement was statistically significantly lower in group BD 2 (0–4) and 2.75 (2–4.5) than in group BM 2.25 (0–4) and 3 (0–4.5), than in group BS 3.25 (3–4) and 4 (3.5–5), respectively, with P-value ˂ 0.001. Although 100% of patients in group BS received pethidine, versus 68.2% of patients in group BM and 63.6% of patients in group BD, with P-value 0.007, the cumulative total pethidine doses given, the duration of post-operative analgesia, and the number of patients who maintained post-operative analgesia for 36 h were comparable between the three groups with P-value 0.170, 0.239, and 0.231, respectively.

Conclusions
In bilateral ultrasound-guided QLB in open abdominal surgeries, the addition of dexamethasone or MgSo4 to bupivacaine reduced the VAS scores and the number of patients experiencing moderate pain at 30 post-operative hours, with fewer patients receiving pethidine and less cumulative total pethidine doses given, with dexamethasone showing better results.
Performance of externally reinforced CHS X-joints subjected to axial loads
Authors: Osman Ashraf , Gerguis Peter , Gaawan Sameh 
Published: May 2023

AbstractCircular hollow sections (CHS) have evolved as the primary choice for the tubular lattice structures, due to their excellent mechanical properties and aesthetic appearance. However, enhancing the joints capacities in such structures poses as challenge to structural designer. Recent research addressed several external reinforcing schemes that can be utilized for strengthening CHS X-joints. Although each of these schemes was studied thoroughly, no collective study was conducted to compare between their efficiencies in enhancing CHS X-joints strengths and stiffnesses. This study focuses on evaluating the structural performance of these techniques relative to each other. The results showed that CHS X-joints strengthened using outer flanged pipe to confine brace-chord intersection achieved the highest strength and stiffness enhancement among the examined joints. Also, it proved that joints strengthened with single or double outer stiffeners yielded acceptable capacity enhancement with the advantages of easy fabrication and acceptable aesthetically appearance.