bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of green creativity on organizations: A case study from the perspectives of leaders and subordinates
Authors: Henriques Paulo Lopes , Jerónimo Helena Mateus , Laranjeira Jéssica 
Published: December 2022

The sustainability framework has a strong influence on the policies, practices and procedures of companies. Green creativity plays a pivotal role in the development of initiatives and innovations for the environmental pillar of sustainability. Based on a survey applied to a Portuguese company with an accredited environmental management system (N = 146), the findings reveal that green creativity is influenced in different ways when analysed from distinct perspectives. The leader's green creativity is positively influenced by the subordinate's green self‐efficacy and personal identification with the leader, whereas the subordinate's green creativity is positively influenced by their green passion and green self‐efficacy, and the leaders' green creativity. This study shows that green creativity develops differentially according to distinct job positions and expectations that in practice must be complementary and synergistic for its effective development.
Drugging non‐coding RNAs—A new light of hope in senescence‐related cancer therapy
Authors: Sarkar Swarupa , Chowdhury Sougata Ghosh , Karmakar Parimal 
Published: December 2022

AbstractCancer is the most prevalent disease of concern worldwide for several decades. Diverse therapeutic aspects are in applications to control this phenomenal disease and also for decennaries. Among many causes and consequences of cancer, senescence has gained much interest in recent times. Senescence, also termed aging, is the natural process that induces cancer in neighboring cells through Senescence‐Associated‐Secretory Phenotypes (SASPs) production. As a cure or preventive measure of cancer progression, studies already light upon multiple proteins and their roles in associated pathways but the aspect of different non‐coding RNAs (ncRNAs) is emerging recently and is under extensive research. Different approaches toward controlling senescence and inhibiting senescent cell accumulation are other aspects of cancer procurement. Thus, the role of ncRNA molecules in senescence and aging is getting much more interest as an alternate therapy for cancer treatment. In this review, at first, the roles of different ncRNAs related to several cellular processes are described. Then we tried to highlight the roles of different non‐coding RNAs in senescence‐induced cancer formation that extends with increasing age and emphasized non‐coding RNAs as a therapeutic target solely or in combination with small molecules where drugging of small molecules targeting these non‐coding RNAs can control cancer development.
HardVis: Visual Analytics to Handle Instance Hardness Using Undersampling and Oversampling Techniques
Authors: Chatzimparmpas A. , Paulovich F. V. , Kerren A. 
Published: December 2022

AbstractDespite the tremendous advances in machine learning (ML), training with imbalanced data still poses challenges in many real‐world applications. Among a series of diverse techniques to solve this problem, sampling algorithms are regarded as an efficient solution. However, the problem is more fundamental, with many works emphasizing the importance of instance hardness. This issue refers to the significance of managing unsafe or potentially noisy instances that are more likely to be misclassified and serve as the root cause of poor classification performance.This paper introduces HardVis, a visual analytics system designed to handle instance hardness mainly in imbalanced classification scenarios. Our proposed system assists users in visually comparing different distributions of data types, selecting types of instances based on local characteristics that will later be affected by the active sampling method, and validating which suggestions from undersampling or oversampling techniques are beneficial for the ML model. Additionally, rather than uniformly undersampling/oversampling a specific class, we allow users to find and sample easy and difficult to classify training instances from all classes. Users can explore subsets of data from different perspectives to decide all those parameters, while HardVis keeps track of their steps and evaluates the model's predictive performance in a test set separately. The end result is a well‐balanced data set that boosts the predictive power of the ML model. The efficacy and effectiveness of HardVis are demonstrated with a hypothetical usage scenario and a use case. Finally, we also look at how useful our system is based on feedback we received from ML experts.
Safety and efficacy of prophylactic anticoagulation versus therapeutic anticoagulation in hospital‐admitted COVID‐19 patients: A systematic review and meta‐analysis of randomized controlled trials
Authors: Rauniyar Robin , Kuikel Sandip , Mishra Aman , Rauniyar Rohit , Yadav Shikha , Thapaliya Sahil , Nepal Amit Sharma , Rauniyar Rahul 
Published: December 2022

AbstractBackgroundCOVID‐19 disease‐related coagulopathy and thromboembolic complication, an important aspect of the disease pathophysiology, are frequent and associated with poor outcomes, particularly significant in hospitalized patients. Undoubtedly, anticoagulation forms a cornerstone for the management of hospitalized COVID‐19 patients, but the appropriate dosing has been inconclusive and a subject of research. We aim to review existing literature and compare safety and efficacy outcomes of prophylactic and therapeutic dose anticoagulation in such patients.MethodsWe did a systematic review and meta‐analysis to compare the efficacy and safety of prophylactic dose anticoagulation when compared with therapeutic dosing in hospitalized COVID‐19 patients. We searched PubMed, Google Scholar, EMBASE and COCHRANE databases from 2019 to 2021, without any restriction by language. We screened records, extracted data and assessed the risk of bias in the studies. RCTs that directly compare therapeutic and prophylactic anticoagulants dosing and are not placebo‐controlled trials were included. Analyses of data were conducted using the Mantel–Haenszel random‐effects model (DerSimonian–Laird analysis). The study is registered with PROSPERO (CRD42021265948).ResultsWe included three studies in the final quantitative analysis. The incidence of thromboembolic events in therapeutic anticoagulation was lower in comparison with prophylactic anticoagulation in hospitalized COVID‐19 patients and reached statistical significance [RR 1·45, 95% CI (1.07, 1.97) I2 –0%], whereas major bleeding as an adverse event was found lower in prophylactic anticoagulation in comparison with therapeutic anticoagulation that was statistically significant [RR 0·42, 95% CI(0.19, 0.93) I2 –0%].ConclusionOur study shows that therapeutic dose anticoagulation is more effective in preventing thromboembolic events than prophylactic dose but significantly increases the risk of major bleeding as an adverse event. So, the risk–benefit ratio must be considered while using either of them.
Biodiversity accounts for the butterflies of the Australian Capital Territory
Authors: Bond Suzi , Vardon Michael 
Published: December 2022

AbstractBiodiversity accounting is promoted as a way of improving the conservation of species and ecosystems. Advancing the theory and practice of biodiversity accounting is driven by the United Nation's standardization of ecosystem accounting in 2021 and a desire to make production of ecosystem accounts commonplace and useful. While the theory of biodiversity accounting has advanced, in practice few accounts have been produced and all have focused on iconic or threatened species. We present a set of novel biodiversity accounts for the 92 butterfly species of the Australian Capital Territory (ACT), spanning 1978–2021, using historical records and systematic surveys of 224 sites between 2014–15 and 2020–21 in the Southern Hemisphere survey season (Spring‐Autum). We conclude that species level biodiversity accounting is useful for biodiversity conservation and that species accounting must go beyond accounting for iconic and threatened species and reflect other characteristics, such as the distribution, abundance, residential status, breeding status, endemism, and ecological status of all species. Habitat specialization provides a link to ecosystem condition accounting, with changes in the distribution and abundance of habitat specialists a likely indicator of ecosystem condition. With such information, species accounts can be used to assess and target conservation activity and examples for ACT butterflies are provided.
Pharmacokinetics, pharmacodynamics, safety and tolerability of cilofexor, a novel nonsteroidal Farnesoid X receptor agonist, in healthy volunteers
Authors: Younis Islam R. , Kirby Brian J. , Billin Andrew N. , Xiao Deqing , Song Qinghua , Watkins Timothy R. , Othman Ahmed A. 
Published: December 2022

AbstractCilofexor is a nonsteroidal farnesoid X receptor (FXR) agonist being evaluated for treatment of nonalcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC). This work characterized the pharmacokinetics, pharmacodynamic, safety, and tolerability of cilofexor in healthy participants. Cilofexor single and multiple once‐daily doses (10 to 300 mg fasting or fed and twice‐daily doses [15 and 50 mg; fed]; tablet formulation) were evaluated. In each cohort, participants were randomized to active drug or placebo in a 4:1 ratio (planned n = 15/cohort). Multiple dosing was for 14 days. Pharmacokinetic and pharmacodynamic samples were collected and safety and tolerability were assessed. Overall, 120 participants were enrolled in the study and 118 participants received at least one dose of study drug. Cilofexor pharmacokinetics followed bi‐exponential disposition and its exposure increased in a less‐than‐dose‐proportional manner over the 10 to 300 mg dose range, with no significant accumulation with repeated dosing. Moderate‐fat meal reduced cilofexor area under the plasma concentration versus time curve (AUC) by 21% to 45%. Cilofexor increased plasma levels of fibroblast growth factor19 (FGF19) and reduced the serum bile acid intermediate 7α‐hydroxy‐4‐cholesten‐3‐one (C4) and bile acids in an exposure‐dependent manner. Cilofexor doses >30 mg appeared to achieve the plateau of intestinal FXR activation. Cilofexor was generally well tolerated; all treatment‐emergent adverse events (TEAEs) were mild or moderate in severity, with headache being the most frequently observed TEAE. The pharmacokinetics pharmacodynamic safety, and tolerability results from this study supported further evaluations, and informed dose selection, of cilofexor in phase II studies in patients with NASH and PSC.
Why did Chinese state‐owned enterprises have higher export propensity? A study based on 2003–2007 data
Authors: Luo Wei , Lu Yue , Shi Huimin 
Published: December 2022

AbstractCompared with privately owned enterprises (POEs), Chinese state‐owned enterprises (SOEs) are 6 percent more likely to export, although SOE productivity and external financial ability are 0.9 percent and 20% lower, respectively. To account for SOEs' higher export propensity, we build a model of firms' export decisions, embodying productivity, internal and external financing ability, and two aspects of China's institutional background: invisible subsidies to SOEs and preferential lending. We apply the model to firms from the Chinese Industrial Enterprise Survey Data, from 2003 to 2007, and find that SOEs' advantages in receiving invisible subsidies and more bank loans can significantly explain their higher export propensity.
Early‐onset venous thromboembolisms in newly diagnosed non‐promyelocytic acute myeloid leukemia patients undergoing intensive induction chemotherapy
Authors: Koschade Sebastian E. , Stratmann Jan A. , Steffen Björn , Shaid Shabnam , Finkelmeier Fabian , Serve Hubert , Miesbach Wolfgang , Brandts Christian H. , Ballo Olivier 
Published: December 2022

AbstractObjectives and MethodsVenous thromboembolic (VTE) events are emerging as frequent complications in acute myeloid leukemia (AML); however, there is insufficient data regarding epidemiology, risk factors, and impact on outcomes. The optimal approach to balance risks of thrombosis and hemorrhage remains unclear. This retrospective single‐center study in AML patients undergoing induction chemotherapy between 2007 and 2018 assessed incidence, risk factors, features, and outcomes of early‐onset VTE.Results423 patients (median age 59 years) were enrolled. VTE was diagnosed in 31 patients (7.3%) within 3 months of admission. The median time to VTE was 3 days. Non‐central venous catheter (CVC)‐related VTE occurred in 19 patients (61%). Main risk factor for VTE was leukocytosis at admission, independent of platelet counts/INR. Four patients (13%) exhibited VTE recurrence. No deaths directly related to VTE or major bleeding events associated with platelet‐adjusted anticoagulation in patients with VTE were recorded. There was no clear impact of VTE on 1‐year overall survival; however, non‐CVC‐related VTE may be associated with adverse outcomes.ConclusionsEarly‐onset VTE is a common complication in newly diagnosed AML patients admitted for induction chemotherapy. Leukocytosis is an independent VTE risk factor. The potentially adverse impact of non‐CVC‐related VTE merits further study.
Impacts of healthy marriage and relationship education for expectant and new mothers
Authors: Patnaik Ankita , Wood Robert G. , Gonzalez Kathryn 
Published: December 2022

AbstractObjectiveTo build the evidence base on healthy marriage and relationship education (HMRE) programs serving individual adults, this study examined the 1‐year impacts of the MotherWise program, which serves women with low incomes who are pregnant or have just had a baby.BackgroundDespite the increasing prevalence of HMRE programs serving individual adults, few studies have rigorously examined their effectiveness.MethodWomen were randomly assigned to either (a) an intervention group offered MotherWise (n = 512), or (b) a control group not offered MotherWise (n = 437). Women's relationship skills, attitudes, and outcomes were measured by a 1‐year follow‐up survey.ResultsMotherWise improved women's relationship skills and attitudes, and reduced the likelihood of unintended pregnancy. MotherWise did not affect levels of intimate partner violence, coparenting quality, and emotional well‐being. Among women in a relationship with their baby's father, MotherWise improved the quality of that relationship.ConclusionMotherWise met its immediate goal of helping women develop the skills and attitudes to make informed, healthy decisions about relationships. The program's impact on unintended pregnancy suggests the program encouraged women to make more deliberate decisions about family planning.ImplicationsPrograms like MotherWise can improve certain outcomes of new and expectant mothers with low incomes by offering them HMRE services and other supports.
Effects of a theory‐based exercise intervention on physical activity levels and health‐related outcomes in older people with chronic diseases
Authors: Li Qiyu , Cai Weiwei , Li Yanling , Zhang Ruixin , Zeng Chunlu , Ma Xiaoqing , Barka Catherine Katumu , Zhang Chu , Sun Ting , Xie Hui 
Published: December 2022

BackgroundThe benefits of physical activity are well‐documented, and the prevalence of physical inactivity is high in older patients with chronic diseases. This study aimed to investigate the impact of an aerobic exercise intervention based on the capacity, opportunity, motivation‐behavior (COM‐B) model on physical activity and health‐related outcomes in this population.MethodsThirty‐five participants were randomly assigned to the intervention group (IG) for an exercise intervention based on the COM‐B model, and 33 were assigned to the control group (CG) for usual care. Physical activity levels, daily steps and bone mineral density T‐value, body mass index, waist–hip ratio, subendocardial myocardial viability rate, central arterial pressure, growth index, brachial–ankle pulse wave velocity, ankle–arm index were measured at baseline, during the 12‐week intervention, and after the 12‐week follow‐up.ResultsCompared with the CG and pre‐intervention, total physical activity in the IG increased significantly (P < 0.05); however, after the 12‐week follow‐up, total physical activity decreased. At the same time, the average daily steps of the elderly in both groups increased. Compared with the CG, at the 12‐week follow‐up, the bone mineral density T‐value in the IG was significantly improved (P < 0.05). Compared with the pre‐intervention values, during the 12‐week intervention, bone mineral density T‐value, body mass index, waist–hip ratio, subendocardial myocardial viability rate and central arterial pressure were significantly improved (P < 0.05); after the 12‐week follow‐up, brachial–ankle pulse wave velocity and ankle–arm index were significantly improved (P < 0.05). No statistically significant changes in the growth index were detected, independent of the group and time.ConclusionTheory‐based exercise interventions can change the physical inactivity behavior of older people with chronic diseases, effectively promoting physical activity and improves bone mineral density T‐value, controls body weight, and reduces cardiovascular risk and physiological indicators related to atherosclerosis. Geriatr Gerontol Int 2023; 23: 78–84.
Training design enhancement through training evaluation: Effects on training transfer
Authors: Arabi Elham , Garza Tiberio 
Published: December 2022

AbstractThis research investigates the linkage between training evaluation, learning design and training transfer. A new training evaluation model, (i.e., learning‐transfer evaluation model [LTEM]), was used to examine its ability to provide evaluative evidence through robust assessments in pre‐, post‐ and delayed assessments. The model was used to improve the training design of a nursing training programme and to nudge the stakeholders to change their training practices. A mixed‐methods research approach, called convergent parallel, was employed to study the influence of the LTEM model in training design improvement by assessing the perceptions of nurse trainees, trainers and a nurse educator towards the instructional design of the training programme. A quantitative approach was used to examine the extent to which the improved programme using an iterative design cycle would result in improved performance among four groups (i.e., one baseline and three treatment groups). The integrated data showed that the LTEM model influenced the stakeholders to focus more on skills practice. With this shift of mindset, the training design was enhanced based on the principles of learning design, cognitive science and multimedia principles. Results of the pre‐, post‐ and delayed posttests showed higher mean scores in the three treatment groups compared to the baseline group. For the measure of transfer, while the treatment groups scored higher, there was no statistically significant difference among all four groups. This could be attributed to nurses’ varied levels of experience, negative transfer and the use of different evaluation matrices in the study and by the hospital.
First Randomized Study of Epilepsy Surgery
Authors: Marks William J. 
Published: December 2022

A Randomized, Controlled Trial of Surgery for Temporal-Lobe Epilepsy Wiebe S, Blume WT, Girvin JP, Eliasziw M N Engl J Med 2001;345:311–318 Background Randomized trials of surgery for epilepsy have not been conducted, because of the difficulties involved in designing and implementing feasible studies. The lack of data supporting the therapeutic usefulness of surgery precludes making strong recommendations for patients with epilepsy. We conducted a randomized, controlled trial to assess the efficacy and safety of surgery for temporal-lobe epilepsy. Methods Eighty patients with temporal-lobe epilepsy were randomly assigned to surgery (40 patients) or treatment with antiepileptic drugs for one year (40 patients). Optimal medical therapy and primary outcomes were assessed by epileptologists who were unaware of the patients’ treatment assignments. The primary outcome was freedom from seizures that impair awareness of self and surroundings. Secondary outcomes were the frequency and severity of seizures, the quality of life, disability, and death. Results At one year, the cumulative proportion of patients who were free of seizures impairing awareness was 58 percent in the surgical group and 8 percent in the medical group (P<0.001). The patients in the surgical group had fewer seizures impairing awareness and a significantly better quality of life (P<0.001 for both comparisons) than the patients in the medical group. Four patients (10 percent) had adverse effects of surgery. One patient in the medical group died. Conclusions In temporal-lobe epilepsy, surgery is superior to prolonged medical therapy. Randomized trials of surgery for epilepsy are feasible and appear to yield precise estimates of treatment effects.
Memory Function Related to Hippocampal Imaging Findings
Authors: Cascino Gregory D. 
Published: December 2022

Bilateral Hippocampal Atrophy: Consequences to Verbal Memory Following Temporal Lobectomy Martin RC, Sawrie SM, Knowlton RC, Bilir E, Gilliam FG, Faught E, Morawetz RB, Kuzniecky R Neurology 2001;57:597–604 Background Bilateral hippocampal damage is a risk factor for memory decline after anterior temporal lobectomy (ATL). Objective To investigate verbal memory outcome in patients with temporal lobe epilepsy (TLE) with either unilateral or bilateral hippocampal atrophy as measured by MRI. Methods The authors selected 60 patients with TLE who had undergone ATL (left = 31, right = 29). They determined normalized MRI hippocampal volumes by cursor tracing 1.5-mm slices from three-dimensional MRI acquisition. Hippocampal volumes were defined as atrophic if the volumes were below 2 SD for control subjects. Bilateral hippocampal atrophy was present in 10 patients with left TLE and 11 patients with right TLE. The authors assessed acquisition, retrieval, and recognition components of verbal memory both before and after ATL. Results Groups did not differ across age, education, intelligence, age at seizure onset, or seizure duration. Seizure-free rates after ATL were 70% or higher for all groups. Before surgery, patients with left TLE displayed worse verbal acquisition performance compared with patients with right TLE. Patients with left TLE with bilateral hippocampal volume loss displayed the lowest performance across all three memory components. After surgery, both groups of patients with left TLE exhibited worse verbal memory outcome compared with patients with right TLE. Bilateral hippocampal atrophy did not worsen outcome in the patients with right TLE. A higher proportion of patients with left TLE with bilateral hippocampal atrophy experienced memory decline compared with the other TLE groups. Conclusion Bilateral hippocampal atrophy in the presence of left TLE is associated with worse verbal memory before and after ATL compared with patients with unilateral hippocampal volume loss or right TLE with bilateral hippocampal volume loss.