bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recruitment of both the ESCRT and autophagic machineries to ejecting Mycobacterium marinum
Authors: Gerstenmaier Lilli , Colasanti Ombretta , Behrens Hannah , Kolonko Margot , Hammann Christian , Hagedorn Monica 
Published: May 2023

AbstractCytosolic Mycobacterium marinum are ejected from host cells such as macrophages or the amoeba Dictyostelium discoideum in a non‐lytic fashion. As described previously, the autophagic machinery is recruited to ejecting bacteria and supports host cell integrity during egress. Here, we show that the ESCRT machinery is also recruited to ejecting bacteria, partially dependent on an intact autophagic pathway. As such, the AAA‐ATPase Vps4 shows a distinct localization at the ejectosome structure in comparison to fluorescently tagged Vps32, Tsg101 and Alix. Along the bacterium engaged in ejection, ESCRT and the autophagic component Atg8 show partial colocalization. We hypothesize that both, the ESCRT and autophagic machinery localize to the bacterium as part of a membrane damage response, as well as part of a “frustrated autophagosome" that is unable to engulf the ejecting bacterium.
When conscientiousness differentially pays off: The role of incongruence between conscientiousness and black stereotypes in pay inequality
Authors: Park Hee Man , Judge Timothy A. , Lee Hun Whee , Chung Seunghoo , Zhan Yuhan 
Published: May 2023

AbstractIn this research, we argue that conscientiousness can be a key factor in accounting for the racial pay gap among Black and White workers. Drawing from shifting standard and status characteristics theories and the literature on occupations, we propose that conscientiousness yields differential rewards for Blacks and Whites because of the incongruence between stereotypes about Black workers and conscientiousness. We further suggest the occupational value of status as an occupational‐level boundary condition that affects the relationships between conscientiousness, race, and pay. We first tested our model with a large national panel dataset, the National Longitudinal Survey of Youth 97 (NLSY97), and occupational characteristics scores in the Occupational Information Network (O*NET), finding that the positive effects of conscientiousness on pay were greater for Whites compared to Blacks and that such pay inequality is more pronounced in occupations with high‐status values than in those with low‐status values. A follow‐up experimental study that recruited 202 managers working in the U.S. produced similar results, suggesting that our findings were not attributable to the levels of job performance. Thus, our research demonstrates the role of conscientiousness in generating pay differentials based on race and sheds light on the importance of considering a discrete occupational context that contributes to organizational inequality.
Xiao San, Intermediary between Soviet Literature and Leftist Chinese Literature
Authors: Clark Katerina 
Published: May 2023

AbstractThis article engages the issue of whether communist internationalist culture in Asia evolved vertically, from directives, models, and so on, emanating from Soviet officialdom or the Comintern in particular, or whether it was generated horizontally, through laterally articulated networks and individual contacts. It addresses this question by looking at the case of Emi Siao (Xiao San), a Chinese communist poet and political activist whose career took him to France, Germany, Soviet Russia, and ultimately back to China during the Sino‐Japanese War, and who changed both wives and national party memberships as he moved from country to country. Throughout his life and travels Xiao developed and adhered to a firm conception of what a socialist internationalist literature should be and what it should accomplish, a conception shaped by his close association with revolutionary Russian culture and his efforts to translate that culture to his compatriots. To what degree Xiao succeeded can be measured in part by how well they were reflected in Mao’s Theses on Literature, which were promulgated in 1942 and which became canonical for communist China. Did these theses follow the tenets of Soviet Socialist Realism (in other words, were they derived vertically)? Or did they present a distinctive and more nationally inflected, and thus horizontally generated, version of socialist literature?
Testing a relationship between special districts and nonprofits: Do they substitute or complement?
Authors: Park HyungGun 
Published: May 2023

ObjectiveAs similar modes of public service delivery on behalf of general‐purpose governments, a relationship between special districts(SD) and nonprofit organization are empirically tested.MethodsUsing U.S. data from the Census of Government Finance and the National Center for Charitable Statistics databases between 1997 and 2017, this study regress counts and spending level of SDs on the nonprofits’ counterparts.ResultsFor both counts and spending level, there are positive association between SDs and nonprofit organizations.ConclusionSDs and nonprofit organizations complement each other even when their service domains overlap.
Recent trends in molecular testing and maintenance targeted therapies in ovarian cancer
Authors: Darwish Ahmed , Elyashiv Osnat , Graham Radha , Miller Rowan E 
Published: May 2023

Key content
Surgical cytoreduction and platinum‐based chemotherapy are the mainstays of ovarian cancer treatment, but 70% of patients with advanced‐stage disease will relapse after responding to first‐line chemotherapy.
Recent randomised controlled trials have shown significant improvement in progression‐free survival by adding maintenance therapy including either PARP inhibitors (PARPi), bevacizumab (VEGF‐A inhibitor), or both.
Homologous recombination repair is a pathway to repair DNA breaks; homologous recombination deficiency (HRD) is encountered in approximately 50% of ovarian high‐grade serous cancers (HGSC).
Patients with HRD tumours demonstrate better progression‐free survival outcomes with PARPi.
HRD testing is now approved for patients with high‐grade ovarian cancers including HGSC.
Learning objectives
To understand available molecular testing in ovarian cancer in England and its implications for maintenance treatment strategies.
Ethical issues
Patient consent is required if testing involves germline BRCA1/2 mutation (gBRCA1/2mut) assessment. A positive BRCA1/2mut result might have implications for the patient and their family.
A strengthening of Freiman's 3k−4$3k-4$ theorem
Authors: Bollobás Béla , Leader Imre , Tiba Marius 
Published: May 2023

AbstractIn its usual form, Freiman's theorem states that if and are subsets of of size with small sumset (of size close to ), then they are very close to arithmetic progressions. Our aim in this paper is to strengthen this by allowing only a bounded number of possible summands from one of the sets. We show that if and are subsets of of size such that for any four‐element subset of the sumset has size not much more than , then already this implies that and are very close to arithmetic progressions.
Use of eco-mapping in health services research: a scoping review protocol
Authors: Saragosa Marianne , Singh Hardeep , Steele Gray Carolyn , Tang Terence , Orchanian-Cheff Ani , Nelson Michelle L A 
Published: May 2023

IntroductionPeople with complex health and social needs often require care from different providers and services. Identifying their existing sources of support could assist with addressing potential gaps and opportunities for enhanced service delivery. Eco-mapping is an approach used to visually capture people’s social relationships and their linkages to the larger social systems. As it is an emerging and promising approach in the health services field, a scoping review on eco-mapping is warranted. This scoping review aims to synthesise the empirical literature that has focused on the application of eco-mapping by describing characteristics, populations, methodological approaches and other features of eco-mapping in health services research.Methods and analysisThis scoping review will follow the Joanna Briggs Institute methodology. From the date of database construction to 16 January 2023, the following databases in English will be searched: Ovid Medline, Ovid Embase, CINAHL Ultimate (EBSCOhost), Emcare (Ovid), Cochrane Central Register of Controlled Trials (Ovid) and Cochrane Database of Systematic Reviews (Ovid) Study/Source of Evidence selection. The inclusion criteria consist of empirical literature that uses eco-mapping or a related tool in the context of health services research. Two researchers will independently screen references against inclusion and exclusion criteria using Covidence software. Once screened, the data will be extracted and organised according to the following research questions: (1) What research questions and phenomena of interest do researchers address when using eco-mapping? (2) What are the characteristics of studies that use eco-mapping in health services research? (3) What are the methodological considerations for eco-mapping in health services research?Ethics and disseminationThis scoping review does not require ethical approval. The findings will be disseminated through publications, conference presentations and stakeholder meetings.Trial registration numberhttps://doi.org/10.17605/OSF.IO/GAWYN.
On the Bardeen–Cooper–Schrieffer interaction in quantum graphs
Authors: Romeo Francesco 
Published: May 2023

AbstractWe introduce a real-space version of the Bardeen–Cooper–Schrieffer interaction allowing the investigation of the non-trivial interplay between many-body physics and particles confinement on a quantum graph. When the two-body problem is considered, we find that the two-particle wavefunction is solution of an integro-differential Schrödinger equation. The solution of the two-body eigenproblem shows the presence of a two-particle bound state whose stability is enhanced in graphs with peculiar topology. We demonstrate that the enhancement effect is robust against many-body effects, which can be studied by means of the Richardson exact solution of the many-body problem. These findings suggest that the effective pairing interaction can be enhanced in quantum graphs with appropriate connectivity. Experimental evidences in Josephson junctions arrays are also discussed in connection with the microscopic mechanism described in the present work.
PDE10A Inactivation Prevents Doxorubicin-Induced Cardiotoxicity and Tumor Growth
Authors: Chen Si , Chen Jiawei , Du Wenting , Mickelsen Deanne M. , Shi Hangchuan , Yu Han , Kumar Sparsh , Yan Chen 
Published: May 2023

Background:
Cyclic nucleotides play critical roles in cardiovascular biology and disease. PDE10A (phosphodiesterase 10A) is able to hydrolyze both cAMP and cGMP. PDE10A expression is induced in various human tumor cell lines, and PDE10A inhibition suppresses tumor cell growth. Chemotherapy drug such as doxorubicin (DOX) is widely used in chemotherapy. However, cardiotoxicity of DOX remains to be a serious clinical complication. In the current study, we aim to determine the role of PDE10A and the effect of PDE10A inhibition on cancer growth and cardiotoxicity induced by DOX.

Methods:
We used global PDE10A knockout (KO) mice and PDE10A inhibitor TP-10 to block PDE10A function. DOX-induced cardiotoxicity was evaluated in C57Bl/6J mice and nude mice with implanted ovarian cancer xenografts. Isolated adult mouse cardiomyocytes and a human ovarian cancer cell line were used for in vitro functional and mechanistic studies.

Results:
We found that PDE10A deficiency or inhibition alleviated DOX-induced myocardial atrophy, apoptosis, and dysfunction in C57Bl/6J mice. RNA sequencing study revealed a number of PDE10A-regulated signaling pathways involved in DOX-induced cardiotoxicity. PDE10A inhibition increased the death, decreased the proliferation, and potentiated the effect of DOX on various human cancer cells. Importantly, in nude mice with implanted ovarian cancer xenografts, PDE10A inhibition attenuated tumor growth while protecting DOX-induced cardiotoxicity. In isolated cardiomyocytes, PDE10A contributed to DOX-induced cardiomyocyte death via increasing Top2β (topoisomerase 2β) expression, mitochondrial dysfunction, and DNA damage by antagonizing cGMP/PKG (protein kinase G) signaling. PDE10A contributed to cardiomyocyte atrophy via potentiating FoxO3 (forkhead box O3) signaling via both cAMP/PKA (protein kinase A)- and cGMP/PKG-dependent signaling.

Conclusions:
Taken together, our study elucidates a novel role for PDE10A in cardiotoxicity induced by DOX and cancer growth. Given that PDE10A has been already proven to be a safe drug target, PDE10A inhibition may represent a novel therapeutic strategy in cancer therapy, with effects preventing DOX-induced cardiotoxicity and simultaneously antagonizing cancer growth.
NT‐proBNP and All‐Cause and Cardiovascular Mortality in US Adults: A Prospective Cohort Study
Authors: Echouffo‐Tcheugui Justin B. , Zhang Sui , Daya Natalie , McEvoy John W. , Tang Olive , Juraschek Stephen P. , Ndumele Chiadi E. , Coresh Josef , Christenson Robert H. , Selvin Elizabeth 
Published: May 2023

Background
NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) is strongly associated with mortality in patients with heart failure. Prior studies, primarily in middle‐aged and older populations, have suggested that NT‐proBNP has prognostic value in ambulatory adults.

Methods and Results

We conducted a prospective cohort analysis of adults, aged ≥20 years, in the nationally representative 1999 to 2004 National Health and Nutrition Examination Survey, to characterize the association of NT‐proBNP with mortality in the general US adult population overall and by age, race and ethnicity, and body mass index. We used Cox regression to characterize associations of NT‐proBNP with all‐cause and cardiovascular disease (CVD) mortality through 2019, adjusting for demographics and cardiovascular risk factors. We included 10 645 individuals (mean age, 45.7 years; 50.8% women; 72.8% White adults; 8.5% with a self‐reported history of CVD). There were 3155 deaths (1009 CVD‐related) over a median 17.3 years of follow‐up. Among individuals without prior CVD, elevated NT‐proBNP (≥75th percentile [81.5 pg/mL] versus <25th percentile [20.5 pg/mL]) was associated with a significantly higher risk of all‐cause (hazard ratio [HR], 1.67 [95% CI, 1.39–2.00]) and CVD mortality (HR, 2.87 [95% CI, 1.61–5.11]). Associations of NT‐proBNP with all‐cause and CVD mortality were generally similar across subgroups defined by age, sex, race and ethnicity, or body mass index (all
P
interaction >0.05).

Conclusions
In a representative sample of the US adult population, NT‐proBNP was an important independent risk factor for all‐cause and CVD mortality. NT‐proBNP may be useful for monitoring risk in the general adult population.
Neurovascular Uncoupling Is Linked to Microcirculatory Dysfunction in Regions Outside the Ischemic Core Following Ischemic Stroke
Authors: Staehr Christian , Giblin John T. , Gutiérrez‐Jiménez Eugenio , Guldbrandsen Halvor Ø. , Tang Jianbo , Sandow Shaun L. , Boas David A. , Matchkov Vladimir V. 
Published: May 2023

Background
Normal brain function depends on the ability of the vasculature to increase blood flow to regions with high metabolic demands. Impaired neurovascular coupling, such as the local hyperemic response to neuronal activity, may contribute to poor neurological outcome after stroke despite successful recanalization, that is, futile recanalization.

Methods and Results

Mice implanted with chronic cranial windows were trained for awake head‐fixation before experiments. One‐hour occlusion of the anterior middle cerebral artery branch was induced using single‐vessel photothrombosis. Cerebral perfusion and neurovascular coupling were assessed by optical coherence tomography and laser speckle contrast imaging. Capillaries and pericytes were studied in perfusion‐fixed tissue by labeling lectin and platelet‐derived growth factor receptor β. Arterial occlusion induced multiple spreading depolarizations over 1 hour associated with substantially reduced blood flow in the peri‐ischemic cortex. Approximately half of the capillaries in the peri‐ischemic area were no longer perfused at the 3‐ and 24‐hour follow‐up (45% [95% CI, 33%–58%] and 53% [95% CI, 39%–66%] reduction, respectively;
P
<0.0001), which was associated with contraction of an equivalent proportion of peri‐ischemic capillary pericytes. The capillaries in the peri‐ischemic cortex that remained perfused showed increased point prevalence of dynamic flow stalling (0.5% [95% CI, 0.2%–0.7%] at baseline, 5.1% [95% CI, 3.2%–6.5%] and 3.2% [95% CI, 1.1%–5.3%] at 3‐ and 24‐hour follow‐up, respectively;
P
=0.001). Whisker stimulation at the 3‐ and 24‐hour follow‐up led to reduced neurovascular coupling responses in the sensory cortex corresponding to the peri‐ischemic region compared with that observed at baseline.

Conclusions
Arterial occlusion led to contraction of capillary pericytes and capillary flow stalling in the peri‐ischemic cortex. Capillary dysfunction was associated with neurovascular uncoupling. Neurovascular coupling impairment associated with capillary dysfunction may be a mechanism that contributes to futile recanalization. Hence, the results from this study suggest a novel treatment target to improve neurological outcome after stroke.
A new plant-parasitic nematode species associated with coffee, Rotylenchus bunae n. sp. (Nematoda: Hoplolaimidae) from Jimma, Ethiopia
Authors: Singh Phougeishangbam Rolish , Aseffa Abebe Woldesenbet , Hajihassani Abolfazl , Karssen Gerrit , Bert Wim , Meressa Beira Hailu 
Published: May 2023

Summary
Rotylenchus bunae n. sp. was discovered in the coffee rhizosphere in Gera district of Jimma, Ethiopia, and has been morphologically and molecularly characterised. The new species is identified by a female body length of 725-876 μm, hemispherical lip region with 4-5 lip annuli, stylet length of 28-30 μm, lateral field areolation only in the pharyngeal region, no cuticular striations, pharyngeal gland overlapping intestine dorsally by 15-26 μm, double epiptygma, no clear spermathecae, vulva position at 54-58% of body length from anterior end, prominent fasciculi in mid and posterior body, rounded or sometimes slightly truncated, coarsely crenated tail with 11-13 annuli, and phasmids located at 7-16 annuli anterior to anus. No males were detected. This species was found closely related to other African Rotylenchus species, such as R. unisexus and R. wimbii; however, it could be well separated from them by both morphology and molecular data (D2-D3 of 28S and partial 18S of rDNA).
Between Abstraction and Materiality: Carlos Villa and the Politics of Asian American Art
Authors: Lee Chaeeun 
Published: May 2023

Abstract
In the 1970s and early 1980s, Filipino American artist Carlos Villa developed a set of experimental methods and idioms—namely, abstraction, abject sensibility, and intense materiality—that would accompany his renewed interest in self-identity and community expression. While these strategies coincided with the broader artistic tendency of the 1960s and ’70s toward unconventional materiality and a deliberately indecorous sensibility, Villa’s far-reaching concern for the racialized condition of Filipinx America compels a reconsideration of his work vis-à-vis the historical and discursive contexts of Filipinx America. This article combines formal analysis with readings from Filipinx/Asian American studies and critical theory to argue that Villa’s experimental methods expose and reroute the multifarious ways in which Filipinx America has been subjected to the violence of the visual regimes of colonialism and modernity. They reorient the predicaments of Filipinx America towards imagining alternative modes of existence and possibilities of freedom, and a rethinking of the politics of Asian American art.
On Tehching Hsieh’s Disappearance: Interrupting the Prevailing Narratives of the Artworld
Authors: Yee Michelle 
Published: May 2023

Abstract
In the Clinton Hill neighbourhood of Brooklyn, New York, sits a nondescript eatery called The Market. The restaurant, like many small New York City restaurants, is unremarkable. Little evidence exists to capitalize on the reputation of its owner, famed performance artist Tehching Hsieh. This article examines Tehching Hsieh’s The Market as a continuation of the artist’s renowned oeuvre to consider how the restaurant might represent Hsieh’s lifelong negotiation of the boundary between art and life. By examining the restaurant as a continuation of Hsieh’s work, I consider how understandings of Hsieh’s life and work are constructed upon binaries of immigrant idealism and art world genius, which exemplify the tension between artistry and livelihoods. In arguing that The Market represents a full collapse of art and life, I consider how the restaurant both refuses such binaries and continues the interrogations of labour, withdrawal, and repetition that are present in Hsieh’s lifeworks.
Sonic Infidelities: Performing Time, Space, and Nonalignment in Hương Ngô’s In the Shadow of the Future
Authors: Phan Justin Quang Nguyên 
Published: May 2023

Abstract
Critics have long pointed out that there was nothing “cold” about the Cold War—its wars extended as hot proxy wars impacting spaces outside of the Eastern and Western Blocs. Treating the Cold War as a metaphor, this article analyzes how interdisciplinary artist Hương Ngô mobilizes “sonic performances of infidelities,” a term I use to draw attention to how diasporic bodies reject the polarizing discourses of the Cold War in spatial, temporal, and epistemological terms. By noting how Ngô employs the visual, sonic, and performative, this article identifies how Ngô’s sonic performances of infidelity ultimately construct an alternative to the Cold War that pulls from her feminist refugee aesthetic repertoire; enunciates from the specificity of Vietnamese diasporic life; and is, moreover, in spirited dialogue with the long historical and internationalist ethos of nonalignment.
Thinking and Practicing Like a Scientist?
Authors: Zhang Zhengyan , Chen Ying-Chih , He Guangxi , She Hsiao-Ching , Chen Jhih-Cheng 
Published: May 2023

Abstract
This study aimed to develop a valid and reliable instrument, the Mental Images of Scientists Questionnaire (MISQ), and use the instrument to examine Chinese students’ mental images of scientists’ characters across school levels, regions, living settings, and gender. The final version of the MISQ consisted of four constructs: scientists’ cognitive, affective, lifestyle, and job characters. The results showed that senior high school students gave higher scores for scientists’ cognitive character construct than junior high and elementary school students did. Students from eastern regions, which have a more highly developed economy, gave the highest scores on cognitive and affective character constructs of scientists. Students from western regions, which have a less developed economy, had a relatively negative impression of scientists. Students’ images of scientists’ affective, lifestyle, and job characters were positively correlated with their interests in pursuing scientific careers. Future research to explore the relationships between students’ mental images of scientists’ characters and students’ motivation to pursue science-related careers or to engage in scientific practices are recommended.