bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opening of Cx43-formed hemichannels mediates the Ca2+ signaling associated with endothelial cell migration
Authors: Espinoza Hilda , Figueroa Xavier F. 
Published: May 2023

Abstract
Endothelial cell migration is a key process in angiogenesis. Progress of endothelial cell migration is orchestrated by coordinated generation of Ca2+ signals through a mechanism organized in caveolae. Connexins (Cx) play a central role in coordination endothelial cell function, directly by cell-to-cell communication via gap junction and, indirectly, by the release of autocrine/paracrine signals through Cx-formed hemmichannels. However, Cx hemichannels are also permeable to Ca2+ and Cx43 can be associated with caveolin-1, a structural protein of caveolae. We proposed that endothelial cell migration relies on Cx43 hemichannel opening. Here we show a novel mechanism of Ca2+ signaling in endothelial cell migration. The Ca2+ signaling that mediates endothelial cell migration and the subsequent tubular structure formation depended on Cx43 hemichannel opening and is associated with the translocation of Cx43 with caveolae to the rear part of the cells. These findings indicate that Cx43 hemichannels play a central role in endothelial cell migration and provide new therapeutic targets for the control of deregulated angiogenesis in pathological conditions such as cancer.
Effect of low dissolved oxygen concentration on structure of regenerated passive film of Ti-6Al-4V alloy under continuous wear
Authors: Du Xinyu , Shi Wei , Xiang Song , Tan Yuanbiao 
Published: May 2023

Abstract
Tribocorrosion is one of the most common forms of failure of biomedical titanium alloys. As the passive film of titanium alloy is highly dependent on oxygen conditions, the passivation behavior and the microstructure of the passive film of Ti-6Al-4V under tribocorrosion in 1 M HCl with a low dissolved oxygen concentration (DOC) were studied by means of electron probe microanalysis (EPMA), Ar-ion etched X-ray photoelectron spectroscopy (XPS), focused ion beam (FIB) milling and HRTEM. The results showed that the protective ability of the regenerated passive film decreased sharply under low DOC. Structural characterization indicated that Ti atoms occupied more metal lattice points in the regenerated passive film and that the high dislocation density in the deformed layer caused by wear facilitated the diffusion of Al and V. Finally, the first-principles calculation showed that Al had the minimum vacancy formation energy.
Hsa_circ_0043533 modulates apoptosis and viability of granulosa cells via miR-409-3p/BCL2 and EMT signalling in PCOS: providing a novel perspective of metformin
Authors: Ma Jing , Liu Chang , Zhang Huimin , Zhao Mingzi , Zhu Wenqian , Du Xin , Hao Cuifang 
Published: May 2023

Abstract
PCOS (polycystic ovary syndrome) is an important cause of infertility in women of child birthing age. It was confirmed granulosa cells were associated closely with the process of anomalous follicle formation and ovulation in PCOS. The apoptosis of granulosa cells in PCOS patients is significantly low but the growth is high, which cause accumulation granulosa cells, leading to polycystic ovaries. Non-coding RNAs was demonstrated involving in PCOS, and we found high hsa_circ_0043533 in PCOS. A series of experiments were carried out to investigate the role of hsa_circ_0043533 in PCOS and the mechanism within. Knockdown of hsa_circ_0043533 promoted apoptosis and restrained migration, proliferation, and viability of KGN cells. The regulation of hsa_circ_0043533 on miR-409-3p/BCL2 axis and key EMT (Epithelial-mesenchymal transition) markers was discovered. And the hsa_circ_0043533/miR-409-3p/BCL2 axis was regulated by metformin. This project revealed novel insights into the molecular mechanisms of granulosa cell proliferation and apoptosis in PCOS, demonstrated the new molecular pathogenesis of PCOS.
Was Technologien ermöglichen könnten - Zur Bedeutung Assistiver Technologien für die Lehrer:innenbildung
Authors: Krstoski Igor , Schulz Lea 
Published: May 2023

Die kürzlich verstorbene Behindertenrechtsaktivistin Judy Heumann beschreibt die Bedeutsamkeit digitaler Medien im Sinne Assistiver Technologien (AT): „For most of us, technology makes things easier. For a person with disabilities, it makes things possible” (Edyburn, 2020, S. 11). Zur gleichberechtigten aktiven Teilhabe am Unterricht und damit an Bildung benötigen manche Schüler:innen spezielle Hilfsmittel. Assistive Technologien bieten Optionen der Partizipation (Fisseler, 2020) und lassen sich aufgrund des Fokus auf das Individuum von Barrierefreiheit und Universal Design weitestgehend abgrenzen. Der Beitrag beschreibt den Einsatz von Assistiven Technologien im schulischen Umfeld sowie die Optionen der Implementation im schulischen Alltag. Die einerseits hoch eingeschätzte Relevanz von Assistiven Technologien (Edyburn, 2020) geht gleichzeitig mit einer geringen Implementation in der Schule einher (Bouck & Long, 2021). Diesem Mangel sollte mit einer Lehrer:innenausbildung begegnet werden, die Kompetenzen hervorbringt, die die Lehrkräfte in einem transdisziplinären Team den Einsatz von Assistiven Technologien planen lässt. Der Vorschlag für ein Seminarkonzept für die erste Phase der Lehrer:innenbildung wird abschließend dargelegt.

Abstract
The recently deceased disability rights activist Judy Heumann describes the importance of digital media in terms of assistive technologies (AT): "For most of us, technology makes things easier. For a person with disabilities, it makes things possible" (Edyburn, 2020, S. 11). Some pupils need special aids in order to participate actively in lessons and thus in education on an equal footing. Assistive technologies offer options for participation (Fisseler, 2020) and can be largely distinguished from accessibility and universal design due to the focus on the individual. The article describes the use of assistive technologies in the school environment as well as the options for implementation in everyday school life. The highly rated relevance of assistive technologies (Edyburn, 2020) is accompanied by a low level of implementation in schools (Bouck & Long, 2021). This deficiency should be countered with teacher training that produces competences that allow teachers to plan the use of assistive technologies in a transdisciplinary team. The proposal for a seminar concept for the first phase of teacher education is presented in conclusion.
DAMPAK RELOKASI PEDAGANG KAKI LIMA KE TERAS MALIOBORO YOGYAKARTA
Authors: DP Salsabilla Nathania , Sejati Karisma Wulan , A’yunina Hilma , Dewi Ambar Sari , Nisa Kanita Khoirun 
Published: May 2023

Abstrak: Penelitian ini bertujuan untuk mengetahui dampak sosial ekonomi relokasi pedagang kaki lima di Pedestrian Malioboro ke Teras Malioboro Yogyakarta. Relokasi pedagang tersebut dilakukan oleh Pemerintah Daerah Istimewa Yogyakarta sebagai salah satu strategi penataan Kawasan Malioboro, atau lebih dikenal dengan sumbu filosofis Yogyakarta. Pemindahan pedagang kaki lima ke kawasan terpadu ini diharapkan mampu memberikan kenyamanan dan keteraturan bagi pengunjung Kawasan Malioboro, sekaligus meningkatkan pendapatan bagi pedagang dan pemerintah Yogyakarta. Menggunakan pendekatan kualitatif, penelitian ini menyelidiki dampak relokasi bagi pedagang kaki lima (PKL) dengan melakukan wawancara dan observasi. Data dikumpulkan pada periode November 2022 untuk kemudian dianalisis dengan menggunakan teknik analisis tematik. Penelitian ini menemukan dampak positif dari relokasi PKL dari Pedestrian Malioboro ke Teras Malioboro yaitu tersedianya fasilitas umum yang memadai, keamanan yang terjamin, efisiensi waktu, dan kemudahan mobilitas pedagang. Namun, relokasi ini berdampak negatif bagi pedagang, khususnya terkait pendapatan yang menurun dibandingkan sebelum pindah. Selain itu, PKL di teras Malioboro terbukti mampu beradaptasi dengan kondisi baru, bahkan membuat aturan bersama untuk menghindari konflik.
Kata Kunci:Relokasi; Pedagang Kaki Lima; Sosial Ekonomi; Teras Malioboro.

Abstract: This study aims to determine the socio-economic impact of street vendors relocation at the Pedestrian Malioboro to Teras Malioboro, Yogyakarta. The relocation was carried out by the Yogyakarta Special Region Government as one of the strategies of Malioboro area arrangement, known as the philosophical axis of Yogyakarta. The purpose of this relocation to this integrated area is to provide comfort and order for visitors to the Malioboro area, as well as to increase income for traders and the Yogyakarta Government. Using qualitative research approach, particularly case study research method, this study investigates the impact of relocation for street vendors (PKL) by conducting interviews and observations. Data was collected in the period November 2022, followed by thematic analysis techniques. This study found some positive impacts on the relocation of street vendors from the Pedestrian Malioboro to Teras Malioboro, such as the availability of public facilities, guaranteed security, time efficiency, and ease of trader mobility. However, this relocation has had a negative impact on traders, especially regarding decreased income compared to before moving. Nonetheless, evidence showed that the street vendors on the Teras Malioboro were able to adapt with new conditions by formulating some rules to avoid conflict. Keywords: Relocation; Street vendors; Socioeconomic; Teras Malioboro
The composition of mackinawite
Authors: Rickard David 
Published: June 2023

Abstract
The composition of a mineral is a defining characteristic. The various compositions listed for mackinawite in current mineralogical databases and reference books, such as Fe(Ni)S and Fe1+xS, are both wrong and misleading. Statistical analyses of over 100 mackinawite compositions reported over the last 50 years show a mean composition of Me1.0S where Me = Fe + Co + Ni + Cu. Mackinawite is stoichiometric FeS. As with many sulfide minerals, Ni-, Co-, and, possibly, Cu-rich varieties occur in addition to the simple iron monosulfide. These varieties are best referred to as nickelian mackinawite, cobaltian mackinawite, and cupriferous mackinawite. The results confirm that these metals substitute for Fe in the mackinawite structure rather than being contained in the interstices between the Fe-S layers. Most compositional data on mackinawites derive from electron probe microanalyses of small grains in magmatic/hydrothermal associations. The result means that there is no dichotomy between the composition of ambient temperature synthetic mackinawite (which is supposed to be equivalent to sedimentary mackinawite) and mackinawites from higher temperature associations. The correct representation of the composition of mackinawite has implications for a wide swathe of fundamental science, including the origin of life, the genesis of magmatic ore deposits, the provenance of meteorites as well as industrial applications such as water treatment and steel corrosion. The stoichiometric formulation permits the mackinawite formula to be balanced electronically using conventional Fe and S ionic species. It also enables simple, balanced chemical equations involving mackinawite.
Chitosan complexes with amino acids and whey peptides: Sensory and antioxidant properties
Authors: Halavach Tatsiana , Kurchenko Vladimir , Tarun Ekaterina , Romanovich Roman , Mushkevich Natalia , Kazimirov Alexander , Lodygin Aleksei , Evdokimov Ivan 
Published: May 2023

Chitosan reacts with amino acids and hydrolyzed whey proteins to produce biologically active complexes that can be used in functional foods. The research objective was to obtain chitosan biocomposites with peptides and amino acids with improved antioxidant and sensory properties.
The research featured biocomposites of chitosan and succinylated chitosan with whey peptides and amino acids. The methods of pH metry and spectrophotometry were employed to study the interaction parameters between polysaccharides and peptides, while colorimetry and spectrophotometry served to describe the amino acids content. The antiradical effect was determined by the method of fluorescence recovery. Pure compounds and their complexes underwent a sensory evaluation for bitterness.
Chitosan and succinylated chitosan formed complexes with whey peptides and such proteinogenic amino acids as arginine, valine, leucine, methionine, and tryptophan. The equimolar binding of tryptophan, leucine, and valine occurred in an aqueous chitosan solution (in terms of glucosamine). Methionine appeared to be the least effective in chitosan interaction, while arginine failed to complex both with chitosan and succinylated chitosan. Chitosan and succinylated chitosan biocomposites with peptides and leucine, methionine, and valine proved to be less bitter that the original substances. The samples with arginine maintained the same sensory properties. Chitosan complexes with tryptophan and peptides increased their antioxidant activity by 1.7 and 2.0 times, respectively, while their succinylated chitosan complexes demonstrated a 1.5 fold increase.
Chitosan and succinylated chitosan biocomplexes with tryptophan and whey protein peptides had excellent antioxidant and sensory properties. However, chitosan proved more effective than succinylated chitosan, probably, because it was richer in protonated amino groups, which interacted with negatively charged amino acids groups.
Estimating streamflow of the Kızılırmak River, Turkey with single- and multi-station datasets using Random Forests
Authors: Dogan Mustafa Sahin 
Published: June 2023

Abstract

Predicting missing historical or forecasting streamflows for future periods is a challenging task. This paper presents open-source data-driven machine learning models for streamflow prediction. The Random Forests algorithm is employed and the results are compared with other machine learning algorithms. The developed models are applied to the Kızılırmak River, Turkey. First model is built with streamflow of a single station (SS), and the second model is built with streamflows of multiple stations (MS). The SS model uses input parameters derived from one streamflow station. The MS model uses streamflow observations of nearby stations. Both models are tested to estimate missing historical and predict future streamflows. Model prediction performances are measured by root mean squared error (RMSE), Nash–Sutcliffe efficiency (NSE), coefficient of determination (R2), and percent bias (PBIAS). The SS model has an RMSE of 8.54, NSE and R2 of 0.98, and PBIAS of 0.7% for the historical period. The MS model has an RMSE of 17.65, NSE of 0.91, R2 of 0.93, and PBIAS of −13.64% for the future period. The SS model is useful to estimate missing historical streamflows, while the MS model provides better predictions for future periods, with its ability to better catch flow trends.
Engineered Biosynthesis through the Adenylation Domains from
Nonribosomal Peptide Synthetases
Authors: Lu Zhenhua , Liu Xiao-Huan , Yuan Xinsong , Liu Fei , Wang Tao 
Published: June 2023

Abstract:
Nonribosomal peptide synthetases, consisted of multiple catalytic domains, are involved in the biosynthesis of an important family of bioactive natural products in a coordinated manner. Among the functional domains, adenylation domains are specifically responsible for recognizing carboxylic acid building blocks and synthesizing aminoacyl adenylates. Given their critical roles in the biosynthesis of the growing peptide, A-domains are also referred to as the “gatekeeper”. In this review, very recent developments on the A-domains from NRPSs are reviewed to expand the fun-damental knowledge of the A domain, including knowledge on the structures, functions, and mo-lecular interactions. Several recent examples were also discussed to highlight the great potential of A-domain engineering. This study should provide a framework for the combinatorial biosynthesis or synthetic biology-driven microbial production of novel nonribosomal peptides.
Historia Salezjańskiej Inspektorii pw. św. Wojciecha z siedzibą w Pile (1979-2004)
Authors: Wąsowicz Jarosław 
Published: May 2023

Rok 2004 to 25. rocznica powstania salezjańskiej inspektorii św. Alberta w Pile. Niniejszy artykuł przedstawia zarys historii województwa. Opisuje pracę wykonywaną przez prowincjałów i rady prowincjalne, rozwój duszpasterstwa parafialnego i szkół salezjańskich. W tym artykule znajdziemy również krótką historię salezjańskich wspólnot formacyjnych w Inspektorii Pilskiej, a także opis głównych salezjańskich ruchów młodzieżowych działających obecnie w granicach Prowincja. Ostatnia część artykułu poświęcona jest oddaniu hołdu wybitnym braciom, który należał do prowincji i zmarł w ciągu ostatnich 25 lat.
The COVID-19 Pandemic and Daily Steps in the General Population: Meta-analysis of Observational Studies
Authors: Wu Ziying , Wang Yilun , Zhang Yuqing , Bennell Kim L , White Daniel K , Shen Liusong , Ren Wei , Wei Jie , Zeng Chao , Lei Guanghua 
Published: May 2023

Background
The COVID-19 pandemic has the potential to accelerate another pandemic: physical inactivity. Daily steps, a proxy of physical activity, are closely related to health. Recent studies indicate that over 7000 steps per day is the critical physical activity standard for minimizing the risk of all-cause mortality. Moreover, the risk of cardiovascular events has been found to increase by 8% for every 2000 steps per day decrement.

Objective
To quantify the impact of the COVID-19 pandemic on daily steps in the general adult population.

Methods
This study follows the guidelines of the MOOSE (Meta-analysis Of Observational Studies in Epidemiology) checklist. PubMed, EMBASE, and Web of Science were searched from inception to February 11, 2023. Eligible studies were observational studies reporting monitor-assessed daily steps before and during the confinement period of the COVID-19 pandemic in the general adult population. Two reviewers performed study selection and data extraction independently. The modified Newcastle-Ottawa Scale was used to assess the study quality. A random effects meta-analysis was conducted. The primary outcome of interest was the number of daily steps before (ie, January 2019 to February 2020) and during (ie, after January 2020) the confinement period of COVID-19. Publication bias was assessed with a funnel plot and further evaluated with the Egger test. Sensitivity analyses were performed by excluding studies with low methodological quality or small sample sizes to test the robustness of the findings. Other outcomes included subgroup analyses by geographic location and gender.

Results
A total of 20 studies (19,253 participants) were included. The proportion of studies with subjects with optimal daily steps (ie, ≥7000 steps/day) declined from 70% before the pandemic to 25% during the confinement period. The change in daily steps between the 2 periods ranged from –5771 to –683 across studies, and the pooled mean difference was –2012 (95% CI –2805 to –1218). The asymmetry in the funnel plot and Egger test results did not indicate any significant publication bias. Results remained stable in sensitivity analyses, suggesting that the observed differences were robust. Subgroup analyses revealed that the decline in daily steps clearly varied by region worldwide but that there was no apparent difference between men and women.

Conclusions
Our findings indicate that daily steps declined substantially during the confinement period of the COVID-19 pandemic. The pandemic further exacerbated the ever-increasing prevalence of low levels of physical activity, emphasizing the necessity of adopting appropriate measures to reverse this trend. Further research is required to monitor the consequence of long-term physical inactivity.

Trial Registration
PROSPERO CRD42021291684; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=291684
Identification and Management of Thyroid Dysfunction Using At-Home Sample Collection and Telehealth Services: Retrospective Analysis of Real-World Data
Authors: Gavin Kathleen M , Kreitzberg Daniel , Gaudreau Yvette , Cruz Marisa , Bauer Timothy A 
Published: May 2023

Background
Programs aimed at modernizing thyroid care by pairing at-home sample collection methods with telehealth options may serve an important and emerging role in thyroid care.

Objective
The primary objective of this analysis was to evaluate telehealth use, demographics, and clinical characteristics of a cohort of consumer-initiated at-home laboratory thyroid test users who were also offered the option of follow-up telehealth consultations.

Methods
This was a retrospective analysis of real-world data from a deidentified consumer database of home-collected, mail-in thyroid tests used from March to May 2021 (N=8152). The mean age was 38.6 (range 18-85) years, and 86.6% (n=7061) of individuals identified as female.

Results
In total, 7% (n=587) of test takers fell into a thyroid dysfunction category (overt hypothyroidism: n=75, 0.9%; subclinical hypothyroidism: n=236, 2.9%; overt hyperthyroidism: n=5, 0.1%; and subclinical hyperthyroidism: n=271, 3.3%). Overall, 12% (n=984) of the overall sample opted into a telehealth consultation, with 91.8% (n=903) receiving a nontreatment telehealth consultation and 8.2% (n=81) receiving a treatment telemedicine consultation. Furthermore, 16% (n=96) of individuals with overt or subclinical thyroid dysfunction engaged in telehealth consultations. The majority of treatment consultations (59.3%, n=48) were conducted with people reporting a history of thyroid issues, with 55.6% (n=45) of people indicating wanting to discuss their current thyroid medication and 48% (n=39) receiving a prescription medication.

Conclusions
The combination of at-home sample collection and telehealth is an innovative model for screening thyroid disorders, monitoring thyroid function, and increasing access to care, which can be implemented at a large scale and across a wide range of age groups.
Risk of impaired school performance in children hospitalized with concussion: a population-based matched cohort study
Authors: Lystad Reidar P , McMaugh Anne , Herkes Geoffrey , Browne Gary , Badgery-Parker Tim , Cameron Cate M , Mitchell Rebecca J 
Published: May 2023

Aim: To examine the impact of concussion on objective measures of school performance. Materials & methods: Population-based matched cohort study using linked health and education records of young people aged ≤18 years hospitalized with concussion in New South Wales, Australia, during 2005–2018, and matched comparisons not hospitalized with any injury. Results: Young people with concussion had higher risk of not achieving the national minimum standards for literacy and numeracy assessments, ranging from 30% for numeracy to 43% for spelling, and not completing high school, ranging from 29% for year 10 to 77% for year 12, compared with matched peers. Conclusion: Young people hospitalized with concussion have impaired school performance compared with uninjured matched peers.