bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comprehensive overview on demand side energy management towards smart grids: challenges, solutions, and future direction
Authors: Bakare Mutiu Shola , Abdulkarim Abubakar , Zeeshan Mohammad , Shuaibu Aliyu Nuhu 
Published: March 2023

AbstractDemand-side management, a new development in smart grid technology, has enabled communication between energy suppliers and consumers. Demand side energy management (DSM) reduces the cost of energy acquisition and the associated penalties by continuously monitoring energy use and managing appliance schedules. Demand response (DR), distributed energy resources (DER), and energy efficiency (EE) are three categories of DSM activities that are growing in popularity as a result of technological advancements in smart grids. During the last century, the energy demand has grown significantly in tandem with the increase in the global population. This is related to the expansion of business, industry, agriculture, and the increasing use of electric vehicles. Because of the sharp increase in global energy consumption, it is currently extremely difficult to manage problems such as the characterization of home appliances, integration of intermittent renewable energy sources, load categorization, various constraints, dynamic pricing, and consumer categorization. To address these issues, it is critical to examine demand-side management (DSM), which has the potential to be a practical solution in all energy demand sectors, including residential, commercial, industrial, and agricultural. This paper has provided a detailed analysis of the different challenges associated with DSM, including technical, economic, and regulatory challenges, and has proposed a range of potential solutions to overcome these challenges. The PRISMA reviewing methodology is adopted based on relevant literature to focus on the issues identified as barriers to improving DSM functioning. The optimization techniques used in the literature to address the problem of energy management were discussed, and the hybrid techniques have shown a better performance due to their faster convergence speed. Gaps in future research and prospective paths have been briefly discussed to provide a comprehensive understanding of the current DSM implementation and the potential benefits it can offer for an energy management system. This comprehensive review of DSM will assist all researchers in this field in improving energy management strategies and reducing the effects of system uncertainties, variances, and restrictions.
Comparative study of the synovial levels of RANKL and OPG in rheumatoid arthritis, spondyloarthritis and osteoarthritis
Authors: Quaresma Thaíse Oliveira , de Almeida Sérgio Couto Luna , da Silva Tarcília Aparecida , Louzada-Júnior Paulo , de Oliveira Renê Donizeti Ribeiro 
Published: March 2023

Abstract
Introduction
In chronic arthropathies, there are several mechanisms of joint destruction. In recent years, studies have reported the implication of receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG) in the process of activation and differentiation of osteoclasts, a key cell in the development of bone erosion. The RANKL/OPG ratio is increased in the serum of patients with malignant diseases and lytic bone disease, as well as rheumatoid arthritis (RA). The objective of this study was to measure and compare the concentrations of OPG and RANKL in the synovial fluid (SF) of patients with rheumatoid arthritis, spondyloarthritis (SpA) and osteoarthritis (OA).

Methods
This was an observational and cross-sectional study with 83 patients, 33 with RA, 32 with SpA and 18 with OA, followed up regularly in the outpatient clinics of the Rheumatology Department of the Clinics Hospital of the Ribeirão Preto Medical School-USP. All patients were assessed for indications for arthrocentesis by the attending physicians at the time of SF collection and were evaluated for demographic variables and medication use. Disease activity was assessed in individuals with RA and SpA. The quantification of SF OPG and RANKL levels was performed by ELISA, and the correlations of the results with clinical, laboratory and radiological parameters were assessed.

Results
We found no statistically significant difference in the RANKL and OPG levels among the groups. Patients with RA showed a positive correlation between the SF cell count and RANKL level (r = 0.59; p < 0.05) and the RANKL/OPG ratio (r = 0.55; p < 0.05). Patients with OA showed a strong correlation between C-reactive protein (CRP) and the RANKL/OPG ratio (r = 0.82; p < 0.05). There was no correlation between the OPG and RANKL levels and markers of inflammatory activity or the disease activity index in patients with RA or SpA.

Conclusion
Within this patient cohort, the RANKL/OPG ratio was correlated with the SF cell count in patients with RA and with serum CRP in patients with OA, which may suggest a relationship with active inflammation and more destructive joint disease.
A nonsynonymous mutation in an acetolactate synthase gene (Gh_D10G1253) is required for tolerance to imidazolinone herbicides in cotton
Authors: CHEN Tianzi , LING Xitie , YU Yue , ZHANG Baolong 
Published: March 2023

Abstract
Background
Herbicide tolerance in crops enables them to survive when lethal doses of herbicides are applied to surrounding weeds. Herbicide-tolerant crops can be developed through transgenic approaches or traditional mutagenesis approaches. At present, no transgenic herbicide tolerant cotton have been commercialized in China due to the genetically-modified organism (GMO) regulation law. We aim to develop a non-transgenic herbicide-tolerant cotton through ethyl methanesulfonate (EMS) mutagenesis, offering an alternative choice for weed management.

Results
Seeds of an elite cotton cultivar Lumianyan 37 (Lu37) were treated with EMS, and a mutant Lu37-1 showed strong tolerance to imidazolinone (IMI) herbicides was identified. A novel nonsynonymous substitution mutation Ser642Asn at acetolactate synthase (ALS) (Gh_D10G1253) in Lu37-1 mutant line was found to be the potential cause to the IMI herbicides tolerance in cotton. The Ser642Asn mutation in ALS did not present among the genomes of natural Gossypium species. Cleaved amplified polymorphic sequence (CAPS) markers were developed to identify the ALS mutant allele. The Arabidopsis overexpressing the mutanted ALS also showed high tolerance to IMI herbicides.

Conclusion
The nonsynonymous substitution mutation Ser642Asn of the ALS gene Gh_D10G1253 is a novel identified mutation in cotton. This substitution mutation has also been identified in the orthologous ALS genes in other crops. This mutant ALS allele can be used to develop IMI herbicide-tolerant crops via a non-transgenic or transgenic approach.

Graphical abstract
Dynamics and diversity of symbiotic bacteria in Apolygus lucorum at different developmental stages
Authors: Xue Hui , Zhu Xiangzhen , Wang Li , Zhang Kaixin , Li Dongyang , Ji Jichao , Niu Lin , Gao Xueke , Luo Junyu , Cui Jinjie 
Published: March 2023

Abstract
Background
Apolygus lucorum is a worldwide omnivorous pest damaging a range of crops and causing great economic losses. Symbiotic bacteria living in insects play a key role in the nutrition, physiology, and behavior of hosts. Here, we present an experiment using Illumina HiSeq sequencing targeting the V3–V4 regions of bacteria’s 16S rRNA throughout the entire life cycle of A. lucorum.

Results
The first and second instar nymphs have the largest alpha diversity compared with other life stages of the insect. Bacterial phyla Proteobacteria (72.29%), Firmicutes (15.24%), Actinobacteria (7.76%) exhibit the largest relative abundance in all developmental stages. Erwinia (23.97%) and Lactococcus (10.62%) are the two genera with the highest relative abundance. The relative abundance of Erwinia in the nymph stage is significantly greater than the adult stage, and the relative abundance of Lactococcus in 6-day-old and 9-day-old adult females is higher compared with adult males.

Conclusions
These results reveal that microbial community composition and relative abundance shift dynamically at different life stages, implying that different bacterial phyla and genera may have specific roles in specific life stages such as metabolism, nutrition absorption, detoxification, and reproduction. This study reveals for the first time the community composition and ecological dynamics of symbiotic bacteria throughout the life stages of A. lucorum, and thus may provide insight to new strategies for pest control.
Humans and climate modulate fire activity across Ethiopia
Authors: Harris Lucas B. , Taylor Alan H. , Kassa Habtemariam , Leta Samson , Powell Bronwen 
Published: March 2023

Abstract
Background
Fire occurrence is influenced by interactions between human activity, climate, and fuels that are difficult to disentangle but crucial to understand, given fire’s role in carbon dynamics, deforestation, and habitat maintenance, alteration, or loss. To determine the relative balance of climatic and anthropogenic influences on fire activity, we quantified interannual variability in burned area across Ethiopia from 2001 to 2018 and developed a statistical model to assess climate and human factors contributing to patterns of area burned.

Results
Annual burned area declined nationally and within several regions from 2001 to 2018 and was closely related to climate, particularly antecedent temperature. Of the area that burned at least once, 62% reburned at 1–3-year intervals and the geographic region of frequent-fire areas did not shift over time. Despite increased enforcement of a fire ban over the past 20 years, no strong spatiotemporal shifts in fire occurrence patterns were detected at a national level.

Conclusions
Our results suggest that human influence combined with dynamics of vegetation and fuels strongly influenced fire occurrence in Ethiopia, indicating that geographic variation in cultural fire practices was highly influential and relatively unchanging between 2001 and 2018. In contrast, interannual variability in total burned area was strongly related to climate and the influence of climate on fuel abundance. Our results highlight that climate can strongly influence short-term variability in fire activity even as longer-term patterns may depend more strongly on human influence.
No evidence for associations between brood size, gut microbiome diversity and survival in great tit (Parus major) nestlings
Authors: Liukkonen Martta , Hukkanen Mikaela , Cossin-Sevrin Nina , Stier Antoine , Vesterinen Eero , Grond Kirsten , Ruuskanen Suvi 
Published: March 2023

AbstractBackgroundThe gut microbiome forms at an early stage, yet data on the environmental factors influencing the development of wild avian microbiomes is limited. As the gut microbiome is a vital part of organismal health, it is important to understand how it may connect to host performance. The early studies with wild gut microbiome have shown that the rearing environment may be of importance in gut microbiome formation, yet the results vary across taxa, and the effects of specific environmental factors have not been characterized. Here, wild great tit (Parus major) broods were manipulated to either reduce or enlarge the original brood soon after hatching. We investigated if brood size was associated with nestling bacterial gut microbiome, and whether gut microbiome diversity predicted survival. Fecal samples were collected at mid-nestling stage and sequenced with the 16S rRNA gene amplicon sequencing, and nestling growth and survival were measured.ResultsGut microbiome diversity showed high variation between individuals, but this variation was not significantly explained by brood size or body mass. Additionally, we did not find a significant effect of brood size on body mass or gut microbiome composition. We also demonstrated that early handling had no impact on nestling performance or gut microbiome. Furthermore, we found no significant association between gut microbiome diversity and short-term (survival to fledging) or mid-term (apparent juvenile) survival.ConclusionsWe found no clear association between early-life environment, offspring condition and gut microbiome. This suggests that brood size is not a significantly contributing factor to great tit nestling condition, and that other environmental and genetic factors may be more strongly linked to offspring condition and gut microbiome. Future studies should expand into other early-life environmental factors e.g., diet composition and quality, and parental influences.
Machine-learning-estimation of high-spatiotemporal-resolution chlorophyll-a concentration using multi-satellite imagery
Authors: Chusnah Wachidatin Nisaul , Chu Hone-Jay , Tatas  , Jaelani Lalu Muhamad 
Published: March 2023

AbstractChlorophyll-a concentration for quantifying phytoplankton biomass is commonly used as an indicator for evaluating the trophic level of lakes and water quality. This research aimed to develop a high spatiotemporal-resolution model for the retrieval of chlorophyll-a in inland water. Firstly, the machine learning based models considering Sentinel-2 Multispectral Instrument and Sentinel-3 Ocean and Land Color Instrument (OLCI) images were applied to estimate chlorophyll-a concentrations (R2 = 0.873 and 0.822, respectively). The spatiotemporal fusion was performed to fuse the OLCI and MSI chlorophyll-a images with low temporal resolution but fine spatial-resolution, and with high temporal resolution but coarse spatial-resolution. The random forest was applied to fuse images from two distinct sensors, and to refine the spatial resolution of OLCI estimations to be the same as those of Sentinel-2 MSI. Results showed that the spatiotemporal fusion can estimate dense-temporal 10 m spatial resolution chlorophyll-a concentration in the Tsengwen Reservoir (Root-Mean-Square Error, RMSE = 1.25–1.47 μg L−1). The spatiotemporal fusion model was effectively applied to determine high spatiotemporal-resolution chlorophyll-a measurements in the aquatic system.
Human health risk assessment from exposure to multiple sources of Hexabromocyclododecanes (HBCDs) in Taiwan
Authors: Lo Shih-Lin , Wang Ren-Der , Chen Yi-Ju , Hsu Yuan-Cheng , Luo Yu-Syuan , Wang Gen-Shuh 
Published: March 2023

AbstractHexabromocyclododecanes (HBCDs) are endocrine-disrupting and persistent organic compounds commonly used in consumer products such as styrofoam, fire-resistant curtains, construction, aquaculture products, and food containers. Humans can expose to HBCD via dermal, ingestion, and inhalation routes; however, the inhalation exposure to HBCDs is not well characterized, especially for the size-segregated particles, which could quickly deposit into the respiratory system. In this study, we systematically characterized the dermal and inhalation exposures and performed an aggregate risk assessment of HBCDs in Taiwan. Sampling sites were selected considering the traffic or industrial contribution for air (n = 2, Sanchung, and Taichung) and soil sampling (n = 19, near the industrial zones). The quantitative analysis of HBCDs in extracted samples was achieved using LC–MS/MS. Our results showed that the concentrations of total HBCDs ranged from 0.1 to 6.6 pg m−3 in the particulate matter samples and 0.63 to 187 μg kg−1 in soil samples, where γ-HBCD was the dominant species, followed by α-HBCD and β-HBCD. The total HBCDs in the finest particles (i.e., particle size below 0.49 μm) ranged from N.D. to 1.5 pg m−3. However, no consistent trend was observed for the isomer distribution of HBCDs among air samples. Furthermore, the margin of exposure was the lowest through the ingestion pathway (5152 to 22555) and the highest through the inhalation pathway (6.71 × 105 to 2.09 × 107), showing that HBCD-induced health risk can predominantly attribute to ingestion exposure. Nevertheless, the traffic and industrial contribution of inhalable HBCD deserves further studies.
Imaging evaluation of patellofemoral joint instability: a review
Authors: Barbosa Roberto M. , da Silva Manuel Vieira , Macedo Carlos Sampaio , Santos Cristina P. 
Published: March 2023

AbstractThe multifactorial origin of anterior knee pain in patellofemoral joint disorders leads to a demanding diagnostic process. Patellofemoral misalignment is pointed out as one of the main causes of anterior knee pain. The main anatomical risk factors of patellofemoral instability addressed in the literature are trochlear dysplasia, abnormal patellar height, and excessive tibial tubercle–trochlear groove distance. Diagnostic imaging of the patellofemoral joint has a fundamental role in assessing these predisposing factors of instability. Extensive work is found in the literature regarding the assessment of patellofemoral instability, encompassing several metrics to quantify its severity. Nevertheless, this process is not well established and standardized, resulting in some variability and inconsistencies. The significant amount of scattered information regarding the patellofemoral indices to assess the instability has led to this issue. This review was conducted to collect all this information and describe the main insights of each patellofemoral index presented in the literature. Five distinct categories were created to organize the patellofemoral instability indices: trochlear dysplasia, patellar height, patellar lateralization, patellar tilt, and tibial tubercle lateralization.
Comment on: “exercise training and cardiac autonomic function following coronary artery bypass grafting: a systematic review and meta-analysis”
Authors: Gois Caroline Oliveira , Conceição Lino Sergio Rocha , de Andrade Guimarães Alana Lalucha , Carvalho Vitor Oliveira 
Published: March 2023

Abstract
Background
Low cardiorespiratory fitness is associated with poor prognosis in individuals with coronary artery disease and after coronary artery bypass grafting surgery. Thus, we comment about a meta-analysis that adds important information about the effect of exercise training on cardiac autonomic function in individuals following coronary artery bypass grafting surgery.

Main body
The study by Kushwaha et al. showed positive effects for heart rate variability and heart rate recovery in subjects after coronary artery bypass grafting surgery in response to acute physical training. These data are relevant, since heart rate variability is an independent predictor of for all-cause and cardiovascular mortality for individuals with cardiovascular disorders. Additionally, attenuated heart rate recovery is associated with increased risk for the same outcomes. Moreover, we summarize the quantitative data from studies that compared the effect of physical training in comparison with control group in cardiorespiratory fitness in adults following coronary artery bypass grafting.

Conclusions
Our findings suggest that improvements in peak oxygen consumption result in an additional benefit in adults following coronary artery bypass grafting. Considered that, the increased cardiorespiratory fitness is an independent predictor of longer survival in coronary artery disease.
Evaluation of patient radiation doses using DAP meter in diagnostic radiology procedures in Birjand, Iran
Authors: Zarghani Hassan , Jabbari Masoud , Pandesh Sajjad 
Published: March 2023

Abstract
Background
The concept of diagnostic reference level (DRL) is considered a regular method to optimize radiation protection in diagnostic imaging system. The objective of implementing a reference level for dose is to produce high-quality images by applying a minimum dose of radiation based on the As Low As Reasonably Achievable (ALARA) principle. Therefore, this study aimed to evaluate the status of radiation protection in diagnostic radiology wards of educational hospitals affiliated with Birjand University of Medical Sciences.

Methods
This study was performed during a period of 11-months in the radiology center of the teaching hospital of Birjand University of Medical Sciences. The studied population included 477 patients who were referred to as clinically indicated x-ray radiography. In order to calculate local DRLs, dose area product (DAP) was measured by a DAP-meter (KERMAX-plus SPD, model 120–131 HS) for 11 devices at educational hospitals affiliated with Birjand University of Medical Sciences. The local DRL values was calculated as 75% of the mean DAP distribution for a specific patient trial at each center.

Results
DAP for Chest PA examination was gained to be in the range from 0.12 Gy.cm2 to 0.42 Gy.cm2 with an average value of 0.23 Gy.cm2 which is above the value of the reference level (0.12 Gy.cm2) for Chest PA. For Chest lateral the observed DAP was found to be in the range from 0.18 Gy.cm2 to 1.48 Gy.cm2 with an average value of 0.65 Gy.cm2 and are therefore twice the reference value (0.3 Gy.cm2). The higher DRL values (average = 2.73) are for lumbar spine lateral radiography. It is observed that the DRL values of chest PA, abdomen AP and Lumbar spine AP are much lower with the earlier studies.

Conclusions
The DRLs helps in understanding the current practices in radiographic examinations. Comparison with other hospitals, the scope of dose optimization and ultimately patient dose reduction in hospitals affiliated with Birjand University of Medical Sciences needs further investigation.
Role of multiparametric MRI in characterization of complicated cystic renal masses
Authors: Zakaria Mostafa Ahmed , El-Toukhy Nahed , Abou El-Ghar Mohamed , El Adalany Mohamed Ali 
Published: March 2023

Abstract
Background
Bosniak classification improves sensitivity and specificity for malignancy among cystic renal masses characterized with MRI. The quantitative parameters derived from diffusion-weighted imaging, and contrast enhancement, can be used in distinguishing between benign and malignant cystic renal masses.

Methods
This prospective observational study included 58 patients (39 male and 19 female) with complicated cystic renal mass initially diagnosed by US or CT. All patients underwent multiparametric MRI study (Pre- and Post-Gd-enhanced T1WI, T2WI and DWI) by using 3 Tesla MRI scanner. Each cystic renal lesion was assigned a category based on Bosniak classification. Demographic data were recorded. ADC ratio, dynamic enhancement parameters in both corticomedullary and nephrographic phases as well as absolute washout were calculated and compared using ROC curve analysis.

Results
The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of the multiparametric MRI in categorization of cystic renal masses according to Bosniak classification version 2019 were 90.32%, 100%, 100%, 90% and 94.83%, respectively, which was higher compared to biparametric MRI and conventional MRI.

Conclusions
Multiparametric MRI can be utilized to confidently evaluate cystic renal masses, overcoming the traditional limitations of overlapping morphological imaging features. Quantitative parameters derived from multiparametric MRI allow better evaluation of complex cystic renal tumors to distinguish between benign and malignant complex cystic renal lesions.