bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intratumoral heterogeneity, treatment response, and survival outcome of ER‐positive HER2‐positive breast cancer
Authors: Teruya Natsuki , Inoue Hiroaki , Horii Rie , Akiyama Futoshi , Ueno Takayuki , Ohno Shinji , Takahashi Shunji 
Published: March 2023

AbstractBackgroundER+HER2+ breast cancer requires most types of systemic therapies perioperatively. However, treatment resistance is often experienced. The current study investigated the predictive and prognostic value of intratumoral heterogeneity and conventional clinicopathological factors in patients with ER+HER2+ breast cancer.MethodsThis research included two patient cohorts with ER+HER2+ breast cancer. Cohort A included patients who underwent surgery without neoadjuvant chemotherapy (NAC). Cohort B comprised patients who received NAC followed by surgery. Intratumoral heterogeneity was assessed via ER and HER2 double staining, and the number of cells stained with different patterns of ER and HER2 was counted.ResultsIn total, 11 of 92 tumors in cohort A and four of 45 tumors in cohort B consisted exclusively of double‐positive (ER+ and HER2+) cells (homogeneous). The rest had different combinations of cells (heterogeneous). The pathological complete response (pCR) rates differed based on tumoral cell components but not intratumoral heterogeneity. The pCR rate of tumors with ER−HER2+ cells but without HER2− cells was higher than that of others (45.5% vs 4.3%; p = 0.0013). Low ER and PgR Allred scores indicated better pCR rates than high scores (p = 0.0005 and 0.024, respectively). Multivariate analysis showed that the ER Allred score and cell component of ER−HER2+ cells without HER2− cells were independent predictors of pCR (p = 0.0055 and 0.0081, respectively).In cohort B, posttreatment Ki67, but not pCR, was a prognostic factor of DFS and OS (p = 0.028 and 0.017, respectively). The prognostic value of combined posttreatment Ki67 and pCR was superior to that of either alone. Combined pCR and posttreatment Ki67 had an independent prognostic value for DFS and OS (p = 0.0068 and 0.0101, respectively).ConclusionsIn ER+HER2+ breast cancer, the presence of ER−HER2+ cells without HER2− cells was independently associated with pCR. Combined posttreatment Ki67 and pCR can be more precise in predicting prognosis than pCR alone.
Non‐worrisome scenario of acute abdomen
Authors: Boulas Konstantinos A. , Nathanailidou Maria , Sitaridis Konstantinos , Filippidis Isaac , Tsiariglis Ioannis , Hatzigeorgiadis Anestis 
Published: March 2023

AbstractDifferential diagnosis between benign and life‐threatening pneumatosis intestinalis poses a great dianostic dilemma.
Postpartum fevers, a rare presentation of secondary hemophagocytic lymphohistiocytosis
Authors: Lee Jacqueline , Pham Brian , Karanjawala Zarir E. , Adesina Oyebimpe 
Published: March 2023

AbstractHemophagocytic lymphohistiocytosis (HLH) is a rare disease of excessive immune system activation. We report a case of HLH in a 20‐year‐old primigravid woman who presented with postpartum fevers. She was successfully treated with dexamethasone and anakinra, a deviation from the HLH‐94 protocol, to preserve her ability to breastfeed.
Introducing an esthetic treatment of malocclusion: Ultrasound‐assisted augmentation of premaxilla with injectable hyaluronic acid filler
Authors: Shekarriz Pantea , Shojaee Pardis 
Published: March 2023

AbstractWith advances in the ultrasound‐assisted esthetic procedures, filler injection can successfully be used for cosmetic correction of face structural imperfections. Here, we present a new filler injection method by targeting two anatomic landmarks which effectively improved the appearance of a mandibular prognathism case who was a maxillofacial cosmetic surgery candidate.
Giant cell arteritis with adventitial pattern in a 51‐year‐old man: A case report
Authors: Kapuczinski Abeline , Demeulenaere Nathalie , Tavares Ferreira Nadine , Ciamala Aurélia , Rossi Camélia , Rusu Stefan , Remmelink Myriam , Vandergheynst Frédéric , Léon Marc 
Published: March 2023

AbstractClinical presentation as well as histological or biological findings can sometimes make the diagnosis of giant cell arteritis difficult. Histopathological features of temporal artery biopsy from giant cell arteritis patients are also challenging because of the various described appearances or even finding of clinically normal temporal artery biopsy does not rule out the diagnosis. We here describe the case of a 51‐year‐old man with temporal artery biopsy showing lymphocytes infiltrates in the adventitia corresponding to the so‐called adventitial pattern of giant cell arteritis according to Hernandez‐Rodriguez et al.
Unusual presentation of rheumatoid arthritis in a 106‐year‐old woman: A rare case report
Authors: ALQazzaz Ali , Gorial Faiq I. , Al‐Obaidi Ahmed Dheyaa , Al‐Obaidi Mustafa Najah , Awadh Nabaa Ihsan , Hashim Hashim Talib 
Published: March 2023

AbstractBy reporting this case, we hope to encourage medical professionals to concentrate on diagnosing old patients with unusual presentation of rheumatoid arthritis.
Phytate Enhances Intermediate Adsorption Kinetics on Nickel for Efficient Primary Aniline Electrooxidation
Authors: Li Jiayuan , Wang Wei , Li Yuefei , Ma Yuanyuan 
Published: March 2023

AbstractNickel (Ni)‐based electrocatalysts are promising for use in the primary amine electrooxidation reaction (pAOR) due to the in situ generation of oxygen intermediates on their surface. Herein, phytate‐coordinated Ni foam (PA‐NF) is reported as an efficient pAOR electrocatalyst with a benzylamine oxidation rate of 1.01 mmol h−1 and a benzonitrile selectivity of ∼100 %. Experimental evidence indicated the upshift of the d‐band center of the Ni sites after PA coordination and enhancement of the adsorption kinetics of oxygen intermediates on the PA‐NF surface during the reaction, resulting in high catalytic performance. This work details a facile strategy for enhancing the pAOR performance of Ni‐ and other transition‐metal‐based electrocatalysts.
Pressure mapped squeeze flow (PMSF): Extending rheological characterization of mortars beyond traditional rheometry
Authors: Grandes Franco A. , Rego Andressa C. A. , Rebmann Markus S. , Cardoso Fábio A. , Pileggi Rafael G. 
Published: March 2023

AbstractThe rheometric techniques available for the evaluation of mortars involve a different set of flow conditions. Squeeze flow is based on the compression of the sample with gap reduction and geometric restrictions, providing important information even when phase separation occurs and an evaluation in conditions similar to those found in several practical situations for many classes of materials, including cement‐based and ceramics. Traditional squeeze flow results are related to bulk normal force and height variation of a sample compressed between parallel plates. Additional information regarding boundary conditions at the interfaces or phenomena related to differential flow can be obtained through further instrumentation of the test. The combination of squeeze flow and a pressure mapping technique has been recently proposed, with great potential for the analysis of cement‐based materials and other granular suspensions. In this work, four mortars were evaluated by the pressure mapped squeeze flow (PMSF) method in two different displacement rates, and new ways to analyze the results were developed to expand the understanding of the flow through the technique, including plotting the pressure along multiple circumferences and an analysis of variation in each radial position. PMSF results were also compared to rotational rheometry and flow table tests for the first time, and concepts of interparticle separation were employed to discuss microstructural aspects of the flow. Due to the variety of mix designs (admixtures, particle size distribution, air content, water content, and other factors), the mortars presented diverse behaviors, ranging from primarily viscous or plastic flows to more granular responses (related to friction between particles with localized formation of jammed structures due to liquid phase migration). This work is part of an effort to establish a foundation for PMSF as a rheometric method that can be used for the analysis of a wide range of materials.
Formate Additive for Efficient and Stable Methylammonium‐Free Perovskite Solar Cells by Gas‐Quenching
Authors: Song Wenlong , Wang Xin , Hou Tian , Li Xiaoshan , Chen Hongwang , Yu Yue , Sun Xiaoran , Singh Ambrish , Zhang Meng 
Published: March 2023

AbstractIn order to promote the commercialization of perovskite solar cells, gas‐quenching is considered to be a promising technique for perovskite film fabrication. However, when handling with methylammonium‐free (MA‐free) perovskites, it is often difficult to obtain high‐quality perovskite films by gas‐quenching. Herein, formate additives are employed to regulate the crystallization of MA‐free perovskite, and improve the quality of perovskite films. Different additives of formamidine formate (FAFO) and potassium formate (KFO) is compared to investigate the role of formate groups in the crystallization of perovskite films prepared by gas‐quenching. The FAFO additive facilitates the perovskite crystallization in (001) orientation whereas KFO favors for (111) orientation. The MA‐free device with addition of FAFO demonstrate a champion power conversion efficiency of 20.94 %, compared to that of 20.14 % for KFO devices. In addition, FAFO device also exhibits improved thermal stability in ambient condition without encapsulation, extending the T80 lifetime by 18 times compared to the pristine device.
PROTOCOL: Education and Covid‐19: An evidence and gap map
Authors: Miller Sarah , Keenan Ciara , Early Erin , McConnell Karen , Rodriguez Leonor 
Published: March 2023

AbstractThis is the protocol for a Campbell evidence and gap map. The objectives are as follows: identify and map all existing primary studies, systematic reviews (published and unpublished), guidelines and policies on education during the Covid‐19 pandemic, creating a live, searchable and publicly available evidence and gap map.
Eco‐Friendly Biosorption of Uranium from Aqueous Solutions Using Sepiolite‐Cavex CA37 Composite Biosorbent
Authors: Erden Kadriye Esen , Donat Ramazan 
Published: March 2023

AbstractCavex CA37 is a dental material used for positive tooth impressions. After the mold is taken, it hardens through a fast‐chemical reaction with air, then becomes waste after usage. In this study, natural sepiolite and Cavex CA37 are mixed at certain ratios to obtain a composite SCX‐37 biosorbent that is used for the biosorption of ions from a synthetic aqueous solution. Parameters affecting biosorption, such as solution pH, ambient temperature, contact time, and ion concentration, are investigated. The biosorption of ions on SCX‐37 reaches equilibrium in 120 min with 97.56% efficiency at 30 °C and pH 4. The isotherms (Langmuir, Freundlich, and D‐R) and thermodynamic values of the biosorption of ions on the SCX‐37 biosorbent are calculated according to the obtained data. It is determined that there is a high correlation between experimental results and all three isotherm models. The adsorption capacity is found to be 41.39 mg g−1. The biosorption of ions onto the SCX37 biosorbent is a chemisorption process with an adsorption energy of 40.50 kJ mol−1.
Synthesis and Biological Activities of 11‐ and 12‐Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB and Tyrosyl‐DNA Phosphodiesterase 1 Inhibitors
Authors: Yang Hao , Qin Chao , Wu Min , Wang Fang‐Ting , Wang Wenjie , Agama Keli , Pommier Yves , Hu De‐Xuan , An Lin‐Kun 
Published: March 2023

AbstractHerein, a series of 11‐ or 12‐substituted benzophenanthridinone derivatives was designed and synthesized for the discovery of dual topoisomerase IB (TOP1) and tyrosyl‐DNA phosphodiesterase 1 (TDP1) inhibitors. Enzyme‐based assays indicated that two compounds 12 and 38 showed high TOP1 inhibitory potency (+++), and four compounds 35, 37, 39 and 43 showed good TDP1 inhibition with IC50 values ranging from 10 to 18 μM. 38 could induce cellular TOP1cc formation, resulting in the highest cytotoxicity against HCT‐116 cells (0.25 μM). The most potent TDP1 inhibitor 43 (10 μM) could induce cellular TDP1cc formation and enhance topotecan‐induced DNA damage and showed strong synergistic cytotoxicity with topotecan in both MCF‐7 and MCF‐7/TDP1 cells.
Comparison of genomic profiling of circulating tumor DNA in pancreaticobiliary malignancies in plasma and bile
Authors: Ohyama Hiroshi , Hirotsu Yosuke , Amemiya Kenji , Miura Yoshifumi , Hirose Sumio , Oyama Toshio , Iimuro Yuji , Kojima Yuichiro , Mikata Rintaro , Mochizuki Hitoshi , Kato Naoya , Omata Masao 
Published: March 2023

AbstractBackgroundObtaining sufficient pancreaticobiliary tumor tissue for genomic profiling has limitations. Liquid biopsies using plasma do not provide sufficient sensitivity. Thus, this study aimed to determine the effectiveness of liquid biopsy between bile and plasma for identifying oncogenic and drug‐matched mutations.MethodsThis study created a panel of 60 significantly mutated genes specific to pancreaticobiliary cancer (PBCA) and used it for genomic analysis of 212 deoxyribonucleic acid (DNA) samples (87 bile supernatant, 87 bile precipitate, and 38 plasma) from 87 patients with PBCA. The quantity of extracted DNA from bile and plasma was compared, as were genomic profiles of 38 pairs of bile and plasma from 38 patients with PBCA. Finally, we investigated 87 bile and 38 plasma for the ability to detect druggable mutations.ResultsThe amount of DNA was significantly lower in plasma than in bile (p < .001). Oncogenic mutations were identified in 21 of 38 (55%) patients in bile and nine (24%) in plasma samples (p = .005). Bile was significantly more sensitive than plasma in identifying druggable mutations (p = .032). The authors detected 23 drug‐matched mutations in combined bile and plasma, including five ERBB2, four ATM, three BRAF, three BRCA2, three NF1, two PIK3CA, one BRCA1, one IDH1, and one PALB2.ConclusionsLiquid biopsy using bile may be useful in searching for therapeutic agents, and using the obtained genomic information may improve the prognoses of patients with PBCA.Plain Language Summary

Genomic profiling of formalin‐fixed paraffin‐embedded tissues may provide actionable targets for molecular and immuno‐oncological treatment.

However, most pancreaticobiliary malignancies are unresectable and formalin‐fixed paraffin‐embedded tissues cannot be obtained.

Although comprehensive genomic profiling tests using plasma have been used in recent years, the utility of those using bile is not clear.

Our study revealed that bile identified more drug‐matched mutations than plasma in advanced pancreaticobiliary cancer patients.

Bile may help widen the patient population benefiting from targeted drugs.
Ruxolitinib in cytopenic myelofibrosis: Response, toxicity, drug discontinuation, and outcome
Authors: Palandri Francesca , Breccia Massimo , Mazzoni Camilla , Auteri Giuseppe , Elli Elena Maria , Trawinska Malgorzata M. , Polverelli Nicola , Tiribelli Mario , Benevolo Giulia , Iurlo Alessandra , Tieghi Alessia , Heidel Florian H. , Caocci Giovanni , Beggiato Eloise , Binotto Gianni , Cavazzini Francesco , Miglino Maurizio , Bosi Costanza , Crugnola Monica , Bocchia Monica , Martino Bruno , Pugliese Novella , Biondo Mattia , Venturi Marta , Scaffidi Luigi , Isidori Alessandro , Cattaneo Daniele , Krampera Mauro , Pane Fabrizio , Cilloni Daniela , Semenzato Gianpietro , Lemoli Roberto M. , Cuneo Antonio , Abruzzese Elisabetta , Bartoletti Daniela , Paglia Simona , Vianelli Nicola , Cavo Michele , Bonifacio Massimiliano , Palumbo Giuseppe A. 
Published: March 2023

AbstractBackgroundPatients with cytopenic myelofibrosis (MF) have more limited therapeutic options and poorer prognoses compared with patients with the myeloproliferative phenotype.Aims and MethodsPrognostic correlates of cytopenic phenotype were explored in 886 ruxolitinib‐treated patients with primary/secondary MF (PMF/SMF) included in the RUX‐MF retrospective study. Cytopenia was defined as: leukocyte count <4 × 109/L and/or hemoglobin <11/<10 g/dL (males/females) and/or platelets <100 × 109/L.ResultsOverall, 407 (45.9%) patients had a cytopenic MF, including 249 (52.4%) with PMF. In multivariable analysis, high molecular risk mutations (p = .04), intermediate 2/high Dynamic International Prognostic Score System (p < .001) and intermediate 2/high Myelofibrosis Secondary to Polycythemia Vera and Essential Thrombocythemia Prognostic Model (p < .001) remained associated with cytopenic MF in the overall cohort, PMF, and SMF, respectively. Patients with cytopenia received lower average ruxolitinib at the starting (25.2 mg/day vs. 30.2 mg/day, p < .001) and overall doses (23.6 mg/day vs. 26.8 mg/day, p < .001) and achieved lower rates of spleen (26.5% vs. 34.1%, p = .04) and symptom (59.8% vs. 68.8%, p = .008) responses at 6 months compared with patients with the proliferative phenotype. Patients with cytopenia also had higher rates of thrombocytopenia at 3 months (31.1% vs. 18.8%, p < .001) but lower rates of anemia (65.6% vs. 57.7%, p = .02 at 3 months and 56.6% vs. 23.9% at 6 months, p < .001). After competing risk analysis, the cumulative incidence of ruxolitinib discontinuation at 5 years was 57% and 38% in patients with cytopenia and the proliferative phenotype (p < .001), whereas cumulative incidence of leukemic transformation was similar (p = .06). In Cox regression analysis adjusted for Dynamic International Prognostic Score System score, survival was significantly shorter in patients with cytopenia (p < .001).ConclusionsCytopenic MF has a lower probability of therapeutic success with ruxolitinib as monotherapy and worse outcome. These patients should be considered for alternative therapeutic strategies.
The Dendrobium Orchid: Botany, horticulture, and utilization
Authors: Ketsa Saichol , Warrington Ian J. 
Published: March 2023

AbstractDendrobium, one of the largest genera of tropical orchids, is grown commercially on a large scale with an important economic impact in several ASEAN countries.Dendrobiumorchids can be grown in a wide range of climates, but flower production is best under tropical conditions. Due to being the most popular orchid for cut flower production, many hybrids ofDendrobiumhave been produced with colorful and attractive blooms. Cut flowers ofDendrobiumare popular worldwide. In addition, manyDendrobiumcultivars can be grown as flowering potted plants and for other purposes such as in medicinal applications and for use in decorative products. Postharvest physiology and technology are important in maintaining the quality of both cut flowers and potted plants from production sites to the marketplace. Plants of theDendrobiumgenus also contain a wide diversity of bioactive compounds that can be developed into medicinal and cosmetic products. This review describes the botany, cultivation, postharvest physiology, handling and utilization ofDendrobium.
ESPAR array design for the UHF RFID wireless sensor communication system
Authors: Rahman Md. Moklesur , Ryu Heung‐Gyoon 
Published: March 2023

SummaryIn this paper, in order to improve the received signal strength (RSS) and signal quality, three arrays of electronically steerable parasitic array radiator (ESPAR) antennas are suggested for the ultra‐high frequency (UHF) radio frequency identification (RFID) communication and sensing system applications. Instead of the single antenna, the array antennas have recently been widely used in many communication systems because of their peak gains, better radiation patterns, and higher radiation efficiency. Also, there are some important issues to use the antenna array like high data rates in wireless communication systems and to better understand the many targets or sensors. In this article, a wireless sensor network (WSN) is being investigated to overcome multipath fading and interference by antenna nulling technology that can be achieved through beam control ESPAR array antennas. The proposed ESPAR array antennas exhibit higher gains like 9.63, 10.2, and 12 dBi and proper radiation patterns from one array to another. Moreover, we investigate the mutual coupling effect on the performance of array antennas with different spacing (0.5λ, 0.75λ, λ) and configurations. It is found that the worst mutual coupling reduced by −28 to −34 dB for 2 × 2 array, −3 to −43 dB for 2 × 3 array, and finally −42 dB to −51 dB due to the antenna spacing from 0.5λ to λ. Thus, these suggested antennas could effectively be applied in the WSN communication systems, internet of things (IoT) networks, and massive wireless and backscatter communication systems.
Deep reinforcement learning for resource allocation of mobile communication systems with device‐to‐device underlay
Authors: Pimenta de Freitas Cardoso Gabriel , Henrique Portela de Carvalho Paulo , Roberto de Lira Gondim Paulo 
Published: March 2023

SummaryOver the past few decades, the number of users and services of the mobile communications system has considerably increased, and since its essential resources such as spectrum and energy are limited, their optimization has drawn particular interest. Concomitantly, artificial intelligence (AI) techniques have advanced and their applications have been expanded, including problems of classification, regression, and optimization of tasks of mobile communications systems. Regarding fifth and sixth generations of such systems, the insertion of AI is foreseen toward the allocation of available resources. The present study applied two recently proposed techniques based on deep reinforcement learning algorithms (viz., deep deterministic policy gradient [DDPG] and twin‐delayed DDPG [TD3]), for the power control and spectrum allocation of a mobile communications system with device‐to‐device (D2D) underlay communications. The results show that both algorithms have superior performance to the three algorithms used for comparison: A random algorithm, a greedy algorithm, and REINFORCE, a classical reinforcement learning algorithm. Furthermore, the results show the proposed algorithms have good generalization capability and performed the allocation intelligently, taking into account the relationship between distances separating devices and interference between communications. The results also proved robust in terms of small variations in input data and noise.