bluuebunny/crossref_metadata_2025_split huggingface dataset:
Síndrome inflamatorio multisistémico asociado a enfermedad por Sars Cov 2 en pacientes pediátricos en países de Latinoamérica
Authors: Cárdenas Cárdenas Priscila Michelle , Rivas Toledo Alexis 
Published: September 2023

Introducción: el Síndrome Inflamatorio Multisistémico pediátrico (PIMS) asociado a Covid-19 está considerado como una complicación potencialmente mortal, post-COVID-19, que se caracteriza por un estado pro inflamatorio, con afectación a varios sistemas de órganos, de gravedad variable. La mayoría de la literatura publicada al respecto es de origen anglosajón, por lo que se hizo necesario investigar la literatura reportada en lengua hispana y lusófona, en América Latina.
Metodos: Se desarrolló un estudio observacional, descriptivo. Se tomó como fuentes de información artículos científicos de investigaciones realizadas con la población pediátrica de países de habla hispana y lusófona, con diseño analítico, descriptivo, de series de casos. Se eliminaron revisiones sistemáticas, reportes de caso y artículos de pago. Se tomaron como resultados de interés las manifestaciones clínicas y de laboratorio; así como el tratamiento del PIMS.
Resultados: Se incluyeron 15 investigaciones realizadas en países de América Latina.; con una población total de 305 pacientes en edad pediátrica con Síndrome Inflamatorio Multisistémico asociado a Covid 19 (PIMS). Manifestaciones clínicas: fiebre (80 % al 100 %), dolor abdominal (36%-100%), diarreas (39 %-100 %), vómitos (40%-100 %), exantema (47%-100 %), inyección conjuntival (27%-100%), shock (10%-100%), enfermedad Kawasaki-like (59%-100%), manifestaciones neurológicas (25%-60%), cardiovasculares: derrame pericárdico (17%-40%), disfunción ventricular (30%-50%). Manifestaciones analíticas: leucocitosis, linfopenia, trombocitopenia; incremento de reactantes de fase aguda (proteína C reactiva, procalcitonina, ferritina sérica), incremento de dímero D y fibrinógeno. Tratamiento general: tratamiento del choque, estabilizando hemodinámica, algoritmo ABC (A: manejo de la vía aérea; B: ventilación; C: circulación. Tratamiento específico: inmunoglobulinas intravenosas y/o corticoides; antibioticoterapia empírica, ácido acetil salicílico, a dosis antiinflamatoria o antiagregante, y heparinas de bajo peso molecular. Manejo de las complicaciones.
Conclusiones: En los países de habla hispana y lusófona de América Latina, la presentación clínica, analítica y el manejo de los pacientes pediátricos con síndrome inflamatorio multisistémico asociado a Covid-19; no difieren de las descripciones en la literatura anglosajona.
Brain tumor detection model based on CNN and threshold segmentation
Authors: Jain Jaishree , Sahu Shashank , Dixit Ashish 
Published: September 2023

Brain tumours pose a substantial global health issue, emphasising the criticality of timely and precise identification to ensure optimal treatment outcomes. This research introduces an innovative methodology for the identification of brain tumours by employing a fusion of Convolutional Neural Networks (CNNs) with threshold segmentation techniques. The objective of the suggested model is to improve the precision and effectiveness of brain tumour identification in medical imaging, namely Magnetic Resonance Imaging (MRI) scans. Fast and precise diagnosis is necessary in the medical profession for effective treatment, but current technologies lack this capability. For successful therapy, it is therefore necessary to develop an effective diagnosis application. Global threshold segmentation for pre-processing is used in this study. Image capture and de-noising were completed in the first stage, while classification and regression were completed in the second stage using ML approaches. A computer-aided automated identification method is the computational technique used in this study. This investigation uses one hundred twenty (120) brain scans from a real-time MRI brain database, of them 15 normal and 105 abnormal. According to performance metrics, the accuracy of training and testing pictures was 99.46%. Comparing this method to recently published methods, it is determined that LR-ML with the threshold segmentation has a rapid, precise brain diagnostic system.
Protection of hydrogen peroxide and Metal induced DNA damage by flavonoids
Authors: Thangavel Muthusamy , Gopi Janani , Balakrishnan Deepalakshmi 
Published: September 2023

More recent research has shown that free radicals cause biomolecules to oxidatively damage. This harm has been linked to several human illnesses, diseases, and ageing. Reactive oxygen species (ROS), such as the hydroxide free radical (OH), hydrogen peroxide (H2O2), and superoxide ion (O2-), have been proven to cause oxidative damage to DNA. Naringin, quercetin, and naringinin have been demonstrated to assist in DNA from oxidative damage. The 2,2-diphenylpicrylhydrazyl (DPPH) test was used to gauge the capacity to neutralize free radicals. The method used was founded on spectrophotometric evaluation of the modification in DPPH concentration caused by the interaction with an antioxidant. Based on the apparent contradiction in words, the study shows the impact of quercetin, naringin, and naringinin on DNA damage in the presence of cupric ions and H2O2 using the gel electrophoresis technique. The aforementioned flavonoids acted as a protective agent at low cupric ion concentrations. While hydroxy free radical scavenger (FRS) did not prevent DNA cleavage at greater cupric ion concentrations, flavonoids did. It follows that DNA damage brought on by flavonoids is not simply caused by oxidative stress. The current work will look at a possible mechanism for the development of Copper(II) complexes with quercetin, naringin, and naringinin that promote antioxidant activity. To properly assess the efficacy of naringenin, quercetin, and naringin when combined with chemotherapeutic drugs for the administration of human health benefits, additional in-depth investigations, including clinical trials, are required.
Preparation of Liposomal Formulations of Gentamicin and Ceftiofur Used in Veterinary Medicine
Authors: SUSAR Hasan , ÇELEBİ Murat , ÇELEBİ Çağla , ÇOBAN Özlem , ŞEN Hüseyin , KARAHAN İzzet 
Published: September 2023

Amaç: Veteriner hekimliği alanında klinik tedavide eksikliği bulunan lipozomal ilaçların üretilmesi amaçlanmıştır. Bu araştırma, veteriner kullanımı için seftiofur ve gentamisin lipozomal formülasyonları üretmek ve kalite kontrol çalışmaları yapmak üzere tasarlandı. Gereç ve Yöntem: Gentamisin ve Seftiofur’un lipozomal formülasyonlarının hazırlanması amacıyla Bangham metodu tercih edildi. Bulgular: Sonuç olarak, seftiofur-1 lipozomu partikül boyutu 3934.67 nm, polidispersite indeksi 0.471, zeta potansiyeli -10.3 mV'dir; Ceftiofur-2 lipozomlarında; parçacık boyutu 4573.00 nm, polidispersite indeksi 0.308, zeta potansiyeli -09.9 mV; Ceftiofur-3 lipozomlarında; Parçacık poyutu 479.40 nm, polidispersite indeksi 0.437, zeta potansiyeli -44.8 mV ölçülmüştür. Gentamisin-1 lipozomunda; parçacık boyutu 5185.67 nm, polidispersite indeksi 0.599, zeta potansiyeli -06.5 mV; Gentamisin-2 lipozomunda; parçacık boyutu 4228.00 nm, polidispersite indeksi 0.599, zeta potansiyeli -07.8 mV; Gentamisin-3 lipozomunda; parçacık boyutu 2138.67 nm, polidispersite indeksi 0.565, zeta potansiyeli -06.5 mV ölçülmüştür. Sonuç: Seftiofur ve gentamisinin başarılı bir şekilde lipozomal formülasyonları hazırlandı. Hazurlanan lipozomal formülasyonların kalite kontrol çalışmaları başarıyla gerçekleştirildi. Etkinliklerinin değerlendirilmesinde farmakokinetinetik/farmakodimanik çalışmalarının yapılması gerektiği kanaatine varıldı.
Anahtar Kelimeler: İlaç, Formülasyon, Lipozom, Veteriner.
EFEKTIVITAS PEMBELAJARAN INOVATIF MENGGUNAKAN POWTOON TERHADAP HASIL BELAJAR SISWA PADA MATERI TEKANAN ZAT DI SMP NEGERI 2 DUMOGA
Authors: Pratiwi Nurul , Sompotan Armstrong , Lolowang Jimmy 
Published: September 2023

This study aims to determine the effectiveness of the use of powtoon learning media on science learning outcomes, especially the substance pressure material for class VIII A students at SMP Negeri 2 Dumoga. The type of research used in this research is experimental research with a pre-experimental research design in the form of a one group pretest posttest design, with a quantitative research approach. In this study, the sample was taken using a total sampling technique with class VIII A as the research sample. The results of the study, it showed that: (1) the average score of student learning outcomes after the application of powtoon learning media was 86.4286 while before being given treatment it was 64.5714. (2) there is an increase in student learning outcomes after applying powtoon learning media by obtaining an average gain value of 0.7342 which is in the high criteria. As for the n-gain percent obtained 73.4177 which is in the criteria of being quite effective. (3) the result of the t-test with the paired sample t-test is 0.01, which means that is accepted. From the results of this study it can be concluded that the use of powtoon learning media is effective for science learning outcomes on substance pressure material for class VIII students of SMP Negeri 2 Dumoga.
Pengaruh Teknologi Informasi Terhadap Efektivitas Audit Internal: Efek Mediasi Kualitas Audit
Authors: Lonto Miryam , Pandowo Aditya 
Published: September 2023

Efektivitas fungsi audit internal merupakan bagian penting dalam sistem pemerintahan karena mampu mendeteksi semua risiko kecurangan dalam organisasi sehingga perlu untuk diteliti. Penelitian ini bertujuan untuk menguji pengaruh teknologi informasi terhadap efektivias audit internal yang dimediasi oleh kualitas audit internal. Penelitian ini menggunakan pendekatan kuantitatif, dengan metode survey pada auditor internal yang ada di inspektorat se-Sulawesi Utara dan Badan Pengawas Keuangan dan Pembangunan, dengan teknik sampling adalah sensus. Analisis data menggunakan Partial Least Square. Hasil penelitian menunjukkan bahwa semakin tinggi kualitas audit yang disebabkan oleh teknologi informasi akan meningkatkan efektivitas audit internal dalam mencegah fraud. Penelitian ini mendukung teori institutional dan teori kualitas dan memberikan implikasi bagi inspektorat daerah agar tetap menjaga kualitas audit pada setiap penugasan dan mengupayakan digunakannya aplikasi E-audit untuk mendeteksi secara dini kecurangan yang bisa terjadi pada pemerintah daerah.
Analisis Kesalahan Morfologi dan Sintaksis pada Teks Buku Pembelajaran Bahasa Arab Prespektif Rusydi Ahmad Thu'aimah
Authors: Abidin Moh Zaenal , Ilmiyah Dina Faiqotul , Naja M. Zulfan Badru , Taufiq Mirwan Akhmad 
Published: September 2023

Analisis kesalahan pada penelitian ini bertujuan untuk memberikan evaluasi tehadap buku pembelajaran Bahasa arab " Auto-Drill ngomong Arab" Penerbit; DAMIGO BOOKS (ANDALIMAN BOOKS). No. ISBN; 978-623-7345-31-2. Dengan pendekatan menurut prespektif Rusydi Ahmad Thu'aimah. Analisis kesalahan Teks merupakan sebuah pendekatan atau metode penelitian yang berfungsi sebagai pisau analisis dalam mengetahaui kelayakan dan kualitas dari sebuah karya tulis. Tujuan dari analisis pada artikel ini sebagai upaya mengungkap kesalahan morfologi dan sintaksis pada buku tersebut. Penelitian ini menggunakan metode kualitatif, pendekatan ilmu Bahasa terapan, di bidang shorof dan nahwu ( morfologi-sintaksis). Teknik analisis data menggunakan analisis kesalahan Rusydi Ahmad Thu'aimah. Sumber data primer didapatkan dari buku Auto-Drill ngomong Arab. Teknik pengumpulan data identifikasi dan kategorisasi kesalahan teks, observasi sistematis dan interpretasi hasil. Dalam penelitian ini peneliti berupaya untuk memberikan koreksi terhadap buku Auto-Drill ngomong Arab sehingga penelitian ini bisa sebagai bahan pertimbangan dalam revisi buku buku tersebut.
Pengaruh Kompensasi dan Pengembangan Karir terhadap Motivasi Kerja Karyawan CV Neureus Putra Subang
Authors: Alawiyah Tuti , Saragih Romat 
Published: September 2023

Pengelolaan sumberdaya manusia yang baik berdampak pada motivasi kerja karyawan yang tinggi sehingga didapatkan kinerja yang baik dan berakhir pada peningkatan kinerja perusahaan. Penelitian ini bertujuan mengetahui hubungan kompensasi dan pengembangan karir terhadap motivasi kerja karyawan pada CV Neureus Putra. Motivasi pegawai yang tinggi diduga terjadi diantaranya karena pemberian kompensasi dan pengembangan karir yang memuaskan bagi karyawan. Penelitian ini menggunakan metode kuantitatif dengan jenis penelitian deskriptif dan kausalitas. Pengambilan sampel dilakukan dengan teknik random sampling berjumlah 141 responden dari 219 karyawan CV Neureus Putra, Subang. Analisis data penelitian menggunakan analisis regresi linear berganda dengan bantuan aplikasi SPSS versi 26. Hasil penelitian menunjukan kompensasi masuk pada kategori sangat memuaskan, pengembangan karir termasuk pada kategori sangat memuaskan dan motivasi juga termasuk pada kategori sangat memuaskan. Hasil penelitian menunjukan bahwa kompensasi dan pengembangan karir berpengaruh positif dan signifikan baik secara parsial maupun simultan.
Implikasi Teori Belajar Kognitivistik Jerome S Bruner dalam Pembelajaran PAI
Authors: Assyakurrohim Dimas , Putra Agung Mandala , Suryana Ermis , Abdurrahmansyah Abdurrahmansyah 
Published: September 2023

Tulisan ini bertujuan untuk membahas serta menganalisis tentang teori belajar Kognitivistik mulai dari pengertian, proses belajar mengajar, tahapan belajar mengajar, alat-alat mengajar, implikasinya serta kelebihan dan kekurangan dari teori kognitivistik. Teori ini menjelaskan bahwa proses belajar akan berjalan dengan baik dan kreatif jika guru memberi kesempatan kepada siswa untuk menemukan suatu aturan (termasuk konsep, teori, definisi, dsb) melalui contoh-contoh yang menggambarkan (mewakili) aturan yang menjadi sumber. Dalam mengkaji artikel ini menggunakan metode penelitian kepustakaan (library research) dengan mengkaji kritis dan mendalam terhadap bahan-bahan pustaka yang relevan dengan materi makalah seperti buku dan jurnal yang layak dijadikan referensi. Implikasi Teori Bruner dalam Proses Pembelajaran adalah menghadapkan anak pada suatu situasi yang membingungkan atau suatu masalah. Dengan demikian Teori kognitif juga menekankan bagian-bagian dari situasi yang saling berhubungan dengan seluruh kontek situasi tersebut.
Konsepsi dan Implementasi One Day One Verse di PMI Dea Malela
Authors: Maksum Muh. Nur Rochim , Salahudin Salahudin 
Published: September 2023

Al-Qur’an dalam pandangan umat Islam, ia sebagai pedoman hidup. Ayat-ayat demi ayat memiliki makna dan kandungan yang sangat mendalam melebihi para penyair terkenal sekalipun. Dengan demikian ummat Islam sangat perlu memahami isi kandungan Al-Qur’an agar bisa direnungkan dan diamalkan. One Day One Verse (ODOV) memiliki peran penting dalam meningkatkan pemahaman santri dan santriwati di Pesantren Modern Internasional (PMI) Dea Malela. One Day One Verse menjadi salah satu program unggulan PMI Dea Malela karena cukup berbeda dengan program lainnya seperti program tahfidz dan sejenisnya. Program ini sebagaimana namanya disampaikan hanya “satu hari satu ayat” dengan memilih ayat-ayat yang di dalam al-Qur’an seputar ayat-ayat aqidah, ayat-ayat akhlaq, dan ayat-ayat seputar peradaban dan sebagainya. Tujuannya, santriwan dan santriwati dapat menghafal, memahami, mentadabbur, dan mengaplikasikan ayat ODOV. Metode penelitian yang disajikan adalah metode studi kasus dengan dipadukan berbagai referensi terkait. Dengan demikian penelitian ini termasuk penelitian deskriptif, yang berfokus pada penjelasan sistematis tentang fakta yang diperoleh saat penelitian dilakukan. Subyek penelitian adalah santriwan dan santriwati dengan melakukan wawancara serta pengamatan kegiatan secara langsung. Hasil penelitian menunjukkan bahwa santriwan dan santriwati PMI Dea Malela sangat mendukung kegiatan ini karena dirasa memiliki dampak positif terhadap pemahaman mereka mengenai ayat-ayat al-Qur’an. Secara aplikatif, ayat-ayat yang dihafalkan beberapa sudah diamalkan dalam kehidupan sehari-hari.
The Effects of Curcumin Supplementation on Glycaemic Index in Women with Polycystic Ovarian Syndrome: An Evidence Based Case Report
Authors: Kumala Marcia , Mutu Manikam Nurul Ratna 
Published: September 2023

Background: PCOS is the most common cause of infertility around the world. PCOS is associated with impaired glucose tolerance and higher tendency to develop type 2 diabetes. Curcumin, which is known for its anti-inflammatory, antioxidant, and antidiabetic properties, may show promising effect in regulating blood glucose.
Objective: This study aims to evaluate the effect of curcumin supplementation on improving glycaemic profile in women with PCOS.
Methods: Literature searching was conducted by advanced searching in Pubmed, Cochrane Library, Scopus, and ProQuest database using MeSH Terms combined with Title/Abstract. After removing duplicates, the literatures were screened based on the eligibility criteria. Critical appraisal and level of evidence of the selected literatures were determined based on Oxford Centre for Evidence-Based Medicine.
Results: Two selected literatures were relevant to answer our clinical question. The first literature is a systematic review/meta-analysis study by Chien et al (2021) and the latter is a randomized controlled trial by Asan et al (2020). Both literatures show that curcumin supplementation is beneficial in improving glycaemic profile in PCOS patients. These effects were marked by lower fasting blood glucose, insulin level, and HOMA-IR in curcumin group compared to the control group.
Conclusion: Curcumin supplementation for at least 6 weeks significantly improve glycaemic profile in women with PCOS. Curcumin supplementation is also considered safe and well tolerable. However, more studies are needed to investigate further regarding the long-term effects of curcumin supplementation.
Keywords: curcumin, turmeric, polycystic ovarian syndrome, glycaemic profile
The epidemiology of Road Traffic Crashes in Rural Zambia: A Retrospective Hospital-Based Study at Monze Mission Hospital
Authors: Sichembe Wantula , Manyozo S D , Moodie R 
Published: September 2023

Background:
Road trauma represents a significant yet neglected public health challenge in Zambia leading to loss of lives, severe disabilities and hampering development. It disproportionately affects low and middle income countries (LMIC) with 90% of all road deaths occurring there. Zambia, like many other LMIC lacks robust evidence to guide road safety initiatives and program planning due to limited research, poor quality data and competing health priorities.
Objectives:
We aimed to investigate the epidemiology of road trauma cases seen at a general hospital in Monze district from 2013 to 2017. We further assessed the road trauma data quality as captured by the hospital registry.
Methods:
We reviewed records for all road trauma cases seen at Monze Mission Hospital from 2013 to 2017. Descriptive statistics were used to summarised using means and proportion. We further assess the variables captured for each case that presented at the hospital including socio-demographic and trauma-related details. Depending on the quality of data obtained, statistical methods were applied to explain the epidemiology including Chi-square, t-tests and proportional tests were used to assess the differences in means and proportions, respectively.
Results:
The road trauma data at MMH are very poor evidenced by a lot of missing variables for road trauma cases that would aid understanding of the epidemiology of road trauma cases seen at the facility. However, of the 449 road trauma cases reviewed, 62.4% of these were males. The highest road trauma burden was recorded among those aged 15-44. Time trend analysis shows a decreasing pattern in road deaths in Monze district. The case-fatality rates were very high with more than 90% the of deaths occurring before arrival at the hospital. However, many case files lacked data on occupation, education level, type of road user, type of vehicles involved and time of collision.
Conclusion:
The available data at MMH suggested that young and active people aged 15-44 years were the most affected of road trauma in Monze district, with males experiencing a higher burden than females. The data also showed a decreasing trend in the road trauma burden in Monze district. However, these results should be interpreted with great caution as the data are highly unreliable due to suspected very high levels of underreporting.
Yirminci Yüzyıl Batı Afrikalı Edebiyatçıların Şiirlerinde Toplumsal Meseleler
Authors: Maiga Mohamadou Aboubacar 
Published: September 2023

West African poetry has depicted many aspects of the life of the community, and this is reflected in the odes of many West African poets. Because his poems are directly related to their own lives and the lives of people in society. West African Arabic poetry gave great importance to this aspect, and poets discussed it in their divans. Social poetry is to convey the life of society in all its forms and aspects, and to touch on the lives of people in various fields and the issues that concern them. From this point of view, this research -by using the socio-historical method - aims to examine the details of the social life of West African society and to reveal the social relations and traditions between individuals by examining poetic texts on social life. The importance of this work is due to the fact that it contributes to the recognition of some aspects and different manifestations of social life in West Africa by examining the poems of poets who touch on social aspects. This research answers two questions: What are the most important social issues addressed by the regional writers? Does social poetry reflect the reality of African society as it is? In the research, many social issues, including the positive and negative phenomena that the local poets dealt with in their poetry divans, were mentioned. Among the most important positive themes, there are behaviors that are appreciated in society, such as benevolence to parents, respect for science and teachers, fraternity and social solidarity, justice, and social assistance. As for the negative issues and problems that social poetry struggles with, these include poverty, unemployment, bribery, injustice, corruption, drug abuse, and betrayal. The research is limited to Senegal, Mali, Niger, Burkina Faso, Ghana, and Benin from 16 countries in the West African region. Because the Arabic poems written in these countries differ from those written in the rest of the region in terms of quantity, quality, and style. It contains poems of prominent poets from these countries. These include Malian poets Yacob Doucoure and Amr Abdulatif Sacko, Senegalese poets Tijan Gay, Davud Adekeleken, and Tijan al-Hac Mansur Sy, Burkina Faso poet Ghanami, Ghanaian poet Mohamad Rashad, Benin poets Sulaiman Maysuna and Musa Babatandi, and Niger poet Ali al-Ashly. There are many distinguished poets as for the reasons for the preference of these poets; they gave more importance to social issues compared to other poets in the region and frequently mentioned these issues. However, his poems were written in very plain language and syllabic meter.