bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial intelligence in orthodontics and orthognathic surgery: a bibliometric analysis of the 100 most-cited articles
Authors: Wong Ka Fai , Lam Xiang Yao , Jiang Yuhao , Yeung Andy Wai Kan , Lin Yifan 
Published: August 2023

Abstract
Background
The application of artificial intelligence (AI) in orthodontics and orthognathic surgery has gained significant attention in recent years. However, there is a lack of bibliometric reports that analyze the academic literature in this field to identify publishing and citation trends. By conducting an analysis of the top 100 most-cited articles on AI in orthodontics and orthognathic surgery, we aim to unveil popular research topics, key authors, institutions, countries, and journals in this area.

Methods
A comprehensive search was conducted in the Web of Science (WOS) electronic database to identify the top 100 most-cited articles on AI in orthodontics and orthognathic surgery. Publication and citation data were obtained and further analyzed and visualized using R Biblioshiny. The key domains of the 100 articles were also identified.

Results
The top 100 most-cited articles were published between 2005 and 2022, contributed by 458 authors, with an average citation count of 22.09. South Korea emerged as the leading contributor with the highest number of publications (28) and citations (595), followed by China (16, 373), and the United States (7, 248). Notably, six South Korean authors ranked among the top 10 contributors, and three South Korean institutions were listed as the most productive. International collaborations were predominantly observed between the United States, China, and South Korea. The main domains of the articles focused on automated imaging assessment (42%), aiding diagnosis and treatment planning (34%), and the assessment of growth and development (10%). Besides, a positive correlation was observed between the testing sample size and citation counts (P = 0.010), as well as between the time of publication and citation counts (P < 0.001).

Conclusions
The utilization of AI in orthodontics and orthognathic surgery has shown remarkable progress, particularly in the domains of imaging analysis, diagnosis and treatment planning, and growth and development assessment. This bibliometric analysis provides valuable insights into the top-cited articles and the trends of AI research in this field.
Immersion ultrasound improves the repeatability of shear-wave elastography for measuring median nerve elasticity
Authors: Zhang Zhijun , Wang Hui , Ding Xiaoya , He Shu 
Published: August 2023

Abstract
Objective
To study the factors that influence the measurement of median nerve elasticity, to provide a more reproducible test for the assessment of median nerve elasticity using shear wave elasticity (SWE), and to reduce operator empirical dependence. To compare the repeatability of the median nerve elasticity measurement using immersion SWE with that using contact SWE, analyze the factors affecting SWE measurement, and provide a more repeatable method for doctors without SWE operation experience.

Methods
Two doctors without SWE operation experience measured the median nerve mean elastic modulus (Emean) at the same position and at different time points on the right wrist of 58 healthy volunteers using immersion and contact ultrasound methods. The intraobserver and interobserver repeatability of measurements was assessed using the interclass correlation coefficient (ICC), while the repeatability was assessed using the Bland–Altman diagram.

Results
The intraobserver and interobserver repeatability of the median nerve elasticity measured via contact SWE by inexperienced operators were classified as good, with ICCs of 0.633 (95% CI 0.380–0.783) and 0.552 (95% CI 0.243–0.735), respectively. The intraobserver and interobserver repeatability of the median nerve elasticity measured by immersion SWE were very good, with ICCs of 0.975 (95% CI 0.958–0.985) and 0.942 (95% CI 0.902–0.966), respectively. The intraobserver and interobserver Bland–Altman diagram of median nerve elasticity measured by immersion SWE showed that 98% of the points fell within the 95% limits of agreement. The intraobserver and interobserver Bland–Altman diagram of median nerve elasticity measured by contact SWE showed that 94% of the points fell within the 95% limits of agreement.

Conclusion
Immersion ultrasound can improve the repeatability of median nerve elasticity measurements by inexperienced operators.
Long-term results following atrioventricular septal defect repair
Authors: Schumacher Katja , Marin Cuartas Mateo , Meier Sabine , Aydin Muhammed Ikbal , Borger Michael Andrew , Dähnert Ingo , Kostelka Martin , Vollroth Marcel 
Published: August 2023

Abstract
Background
Atrioventricular septal defects (AVSD) represent 4–7% of congenital cardiac malformations. Definitive early repair is favored over prior pulmonary artery banding and delayed definitive repair in many centers. The aim of this study was to analyze long-term outcomes following AVSD repair over a 21-year period.

Methods
A total of 202 consecutive patients underwent surgical AVSD correction between June 1999 and December 2020. Surgery was performed using the double-patch technique. The study data were prospectively collected and retrospectively analyzed. Primary outcomes were In-hospital mortality and overall long-term freedom from reoperation.

Results
Median age at operation was 120 days (IQR 94–150), median weight was 5.0 kg (4.2–5.3). None of the patients died within the first 30 postoperative days. In-hospital mortality was 0.5% (1/202 patients). Median follow-up was 57 months (11–121). Overall freedom from reoperation at 5, 10 and 15 years was 91.8%, 86.9% and 86.9%, respectively.

Conclusion
AVSD repair with the double-patch technique is a safe and effective procedure with good early postoperative outcomes and low long-term reoperation rates.
Prenatal diagnosis of paternal uniparental disomy for chromosome 2 in two fetuses with intrauterine growth restriction
Authors: Tan Xuemei , Liu Bailing , Yan Tizhen , Wei Xiaobao , Qin Yanfeng , Zeng Dingyuan , Yuan Dejian 
Published: August 2023

AbstractUniparental disomy (UPD) is when all or part of the homologous chromosomes are inherited from only one of the two parents. Currently, UPD has been reported to occur for almost all chromosomes. In this study, we report two cases of UPD for chromosome 2 (UPD2) encountered during prenatal diagnosis. The ultrasound findings of the fetuses from two unrelated families showed intrauterine growth restriction. The karyotype analyses were normal. The two fetuses both had complete paternal chromosome 2 uniparental disomy detected by whole-exome sequencing, but their clinical outcomes were significantly different, with fetal arrest in case 1 and birth in case 2. In this report, we analyzed and discussed the phenotypes of the fetuses in these two cases and reviewed the literature on UPD2.
Anxiety in adults with asthma during the coronavirus disease 2019 pandemic: a Canadian perspective
Authors: Linton Sophia , Xu Kayley , Hossenbaccus Lubnaa , Botting Hannah , Garvey Sarah , Sunavsky Adam , Steacy Lisa M. , Tripp Dean A. , Ellis Anne K. 
Published: August 2023

Abstract
Background
Asthma is a chronic airway inflammatory disease that affects millions of Canadians and often contributes to higher levels of anxiety among patients. Since the coronavirus disease 2019 (COVID-19) pandemic was a time of increased anxiety and fear among the Canadian population, it was thought that those with asthma may experience heightened anxiety levels due to uncertain access to care, the potential to misinterpret asthma symptoms for symptoms of COVID-19 (or vice versa), and the concern about being treated differently by those around them when experiencing asthma symptoms. Therefore, this study sought to perform a cross-sectional analysis of the asthma-anxiety relationship in adults with and without asthma in the unique context of the COVID-19 pandemic from a Canadian perspective.

Methods
This study employed the COVID-19 Associated Anxiety in Allergic Rhinitis and Asthma patients Experiencing Symptoms (CAAARES) survey, consisting of COVID-19-specific questions, the Generalized Anxiety Disorder Assessment-7 (GAD-7) and the Asthma Control Questionnaire-6 (ACQ-6). Data collection occurred through the Qualtrics XM platform and data analyses were conducted with the IBM SPSS Statistics 28 software.

Results
A total of 741 valid responses were collected (asthma group, n = 244; control group, n = 497). 31.6% and 26.2% of respondents in the asthma and control groups, respectively, met the diagnostic criteria for GAD. There was no significant difference (p = .067) in mean GAD-7 scores between the two groups. A Hierarchal Multiple Regression (HMR) model was developed, and neither asthma status nor ACQ-6 score had a significant predictive effect on the GAD-7 score. There was a statistically significant (p < .001) weak positive correlation (r = .22) between GAD-7 and ACQ-6 scores. In a simple mediation (SMM) model, perceived COVID-19 stress of others was not identified as a significant mediator of the relationship between ACQ-6 and GAD-7 (indirect effect β = 0.014).

Conclusion
Our study of a Canadian cohort demonstrates elevated levels of anxiety overall, amongst both asthma and control groups. While AR status was significantly greater in the asthma group, it was not a significant predictive variable of GAD-7 score. Our data suggests that COVID-19-specific factors appear to have a greater contribution to anxiety than asthma status or control.
Emergence of melioidosis in Brazil: a case series
Authors: Velôso Dilbert Silva , da Silva Samuel Pinheiro , de Coelho Conceição Maria Sousa , Parente José Miguel Luz , Veloso Thaline Alves Elias , Lima Murilo Moura , Sampaio Caroline Torres , de Freitas Maria Fátima Alencar Bezerra , Rolim Dionne Bezerra , de Lemos Elba Regina Sampaio , Horta Marco Aurélio Pereira 
Published: August 2023

Abstract
Background
Melioidosis is a serious disease caused by the bacterium Burkholderia pseudomallei which affects humans and animals. It results in a wide spectrum of clinical manifestations, mainly in the respiratory tract, progressing to septic shock and death.

Case presentation
Herein, we present a series of seven patients (median age: 41 years) with confirmed melioidosis, treated at a public hospital in Piauí State, Brazil between 2019 and 2021. The most common clinical presentations were fever, cough, pneumonia, and abdominal pain. The mean duration of antibacterial therapy with 1 g of meropenem was 28.6 ± 1.1 days. Six patients recovered and one died. The mean hospitalization time was 51.0 ± 39.2 days.

Conclusions
Melioidosis is an emerging infectious disease in Brazil. Health professionals in endemic areas need to be aware of the clinical presentation and appropriate clinical management of the disease because early diagnosis and early initiation of antibiotic therapy can be life-saving.
Physiological oxygen conditions enhance the angiogenic properties of extracellular vesicles from human mesenchymal stem cells
Authors: Phelps Jolene , Hart David A. , Mitha Alim P. , Duncan Neil A. , Sen Arindom 
Published: August 2023

AbstractBackgroundFollowing an ischemic injury to the brain, the induction of angiogenesis is critical to neurological recovery. The angiogenic benefits of mesenchymal stem cells (MSCs) have been attributed at least in part to the actions of extracellular vesicles (EVs) that they secrete. EVs are membrane-bound vesicles that contain various angiogenic biomolecules capable of eliciting therapeutic responses and are of relevance in cerebral applications due to their ability to cross the blood–brain barrier (BBB). Though MSCs are commonly cultured under oxygen levels present in injected air, when MSCs are cultured under physiologically relevant oxygen conditions (2–9% O2), they have been found to secrete higher amounts of survival and angiogenic factors. There is a need to determine the effects of MSC-EVs in models of cerebral angiogenesis and whether those from MSCs cultured under physiological oxygen provide greater functional effects.MethodsHuman adipose-derived MSCs were grown in clinically relevant serum-free medium and exposed to either headspace oxygen concentrations of 18.4% O2(normoxic) or 3% O2(physioxic). EVs were isolated from MSC cultures by differential ultracentrifugation and characterized by their size, concentration of EV specific markers, and their angiogenic protein content. Their functional angiogenic effects were evaluated in vitro by their induction of cerebral microvascular endothelial cell (CMEC) proliferation, tube formation, and angiogenic and tight junction gene expressions.ResultsCompared to normoxic conditions, culturing MSCs under physioxic conditions increased their expression of angiogenic genesSDF1andVEGF,and subsequently elevated VEGF-A content in the EV fraction. MSC-EVs demonstrated an ability to induce CMEC angiogenesis by promoting tube formation, with the EV fraction from physioxic cultures having the greatest effect. The physioxic EV fraction further upregulated the expression of CMEC angiogenic genesFGF2,HIF1,VEGFandTGFB1, as well as genes (OCLNandTJP1) involved in BBB maintenance.ConclusionsEVs from physioxic MSC cultures hold promise in the generation of a cell-free therapy to induce angiogenesis. Their positive angiogenic effect on cerebral microvascular endothelial cells demonstrates that they may have utility in treating ischemic cerebral conditions, where the induction of angiogenesis is critical to improving recovery and neurological function.
Geochemical investigation of the mixed Máriahalom vertebrate fauna at the Paleogene–Neogene boundary in the Central Paratethys: environmental conditions and age constrain
Authors: Kocsis László , Rabi Márton , Ulianov Alex , Cipriani Anna , Farkas Izabella M. , Botfalvai Gábor 
Published: August 2023

AbstractThe fossil vertebrate fauna of Máriahalom contains remains from a wide range of ecologies including terrestrial and aquatic mammals, crocodiles, sharks, and rays among others. All these were found mixed in mollusc-rich, shallow water, coastal deposits. The aim of the study is to trace the origin of the fossils using their rare earth element (REE) content and their respective ecology with stable oxygen isotopic compositions. In addition, marine vertebrates and calcareous marine fossils were analysed for their Sr isotope composition to provide a new age estimate for the locality. The REE content and their distribution in the fossils indicate similar early diagenetic environments and possible contemporaneous fossilization for the entire vertebrate assemblage. Reworked fossils of significantly different age can be excluded. The enamel/enameloid-derived phosphate oxygen isotope composition of selected fossil taxa fit well with previously inferred habitats that include marine, brackish, and terrestrial environments. Notably, the stem-pinnipedPotamotherium valletoniis best interpreted as freshwater dweller instead of marine, consistent with the sedimentology of other occurrences. Our novel87Sr/86Sr data suggest an Aquitanian age (21.4 ± 0.5 Ma) for the Máriahalom site that is younger than the previously proposed Late Oligocene age based on biostratigraphy (MP28–30 European Mammal Paleogene Reference Levels). An Aquitanian age raises the possibility that the index fossil taxon, the anthracothere mammalMicrobunodon minimum, may have vanished earlier in Western Europe than in the Central Paratethys region.
MuscleJ2: a rebuilding of MuscleJ with new features for high-content analysis of skeletal muscle immunofluorescence slides
Authors: Danckaert Anne , Trignol Aurélie , Le Loher Guillaume , Loubens Sébastien , Staels Bart , Duez Hélène , Shorte Spencer L. , Mayeuf-Louchart Alicia 
Published: August 2023

AbstractHistological analysis of skeletal muscle is of major interest for understanding its behavior in different pathophysiological conditions, such as the response to different environments or myopathies. In this context, many software programs have been developed to perform automated high-content analysis. We created MuscleJ, a macro that runs in ImageJ/Fiji on batches of images. MuscleJ is a multianalysis tool that initially allows the analysis of muscle fibers, capillaries, and satellite cells. Since its creation, it has been used in many studies, and we have further developed the software and added new features, which are presented in this article. We converted the macro into a Java-language plugin with an improved user interface. MuscleJ2 provides quantitative analysis of fibrosis, vascularization, and cell phenotype in whole muscle sections. It also performs analysis of the peri-myonuclei, the individual capillaries, and any staining in the muscle fibers, providing accurate quantification within regional sublocalizations of the fiber. A multicartography option allows users to visualize multiple results simultaneously. The plugin is freely available to the muscle science community.
More grateful, less addicted! Understanding how gratitude affects online gaming addiction among Chinese college students: a three-wave multiple mediation model
Authors: Gao Bin , Xu Yi , Bai Lu , Luo Gui , Li Weiyi 
Published: August 2023

Abstract
Background
Online game addiction has become a prominent public concern, particularly among emerging adults, warranting in-depth investigation. Despite prior cross-sectional research indicating a negative correlation between gratitude and online gaming addiction, a dearth of longitudinal research exists in this area. Furthermore, the underlying mechanisms that explain the link between gratitude and online gaming addiction remain poorly understood, highlighting a critical research gap in the field.

Methods
To bridge this gap, our study adopted a three-wave longitudinal design and constructed a multiple mediation model. Over the course of one year, data was collected from a sample of Chinese undergraduates, with 319 students participating at Time 1, 305 at Time 2, and 292 at Time 3. Participants were administered online self-report surveys, enabling the acquisition of valuable data regarding their levels of gratitude, online game addiction, self-control, and loneliness.

Results
The findings revealed a negative correlation between gratitude measured at Time 1 and online game addiction assessed at Time 3. Further analysis demonstrated that both self-control and loneliness played multiple mediating roles at Time 2 in the link between gratitude and online game addiction.

Conclusion
These research findings shed light on the underlying mechanisms between gratitude and online game addiction, which provide implications for developing interventions (e.g., interventions based on gratitude) for reducing young adults’ online game addiction.
Super-strong and high-performance electrical film heater derived from silver nanowire/aligned bacterial cellulose film
Authors: Hu Guichun , Varamesh Amir , Zhong Na , Kong Fangong , Hu Jinguang 
Published: August 2023

AbstractHigh-performance electrical Joule heaters with high mechanical properties, low driving voltage, rapid response, and flexibility are highly desirable for portable thermal management. Herein, by using aligned bacterial cellulose (BC) and silver nanowire (AgNW), we fabricated a novel film heater based on Joule heating phenomena. The aligned BC film prepared by stretching BC hydrogel and hot-pressing drying technology showed outstanding mechanical properties and flexibility. The ultrahigh strength of up to 1018 MPa and the toughness of 20 MJ/m3 were obtained for the aligned BC film with 40% wet-stretching (BC-40). In addition, the aligned BC film could be folded into desirable shapes. The AgNW was spray-coated on the surface of aligned BC-40 film and then covered with polydimethylsiloxane to form a P@AgNW@BC heater. P@AgNW@BC heater showed excellent conductivity, which endowed the film heater with an outstanding Joule heating performance. P@AgNW@BC heater could reach ~ 98 ℃ at a very low driving voltage of 4 V with a rapid heating response (13 s) and long-term temperature stability. The P@AgNW@BC heater with such an outstanding heating performance can be used as a flexible heating device for different applications in daily life like deicing/defogging device, wearable thermotherapy, etc.Affiliations: Please check and confirm that the authors and their respective affiliations have been correctly identified and amend if necessary.yes, we confirmed the affiliations are correct.
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Graphical Abstract
Effect of steel and PVA fibres as monofibres on strength and cracking properties of fly ash and slag-based alkali-activated concrete
Authors: Venkateswarlu Mangalapuri , Gunneswara Rao T. D. 
Published: August 2023

AbstractThe present paper explores the experimental study on the influence of steel fibres (SF) and polyvinyl alcohol fibres (PVAF) as monofibres on the strength, and cracking properties of alkali-activated concrete with varying ground granulated blast furnace slag (GGBFS) and fly ash amounts was examined under ambient curing in this study. The alkali activator was a mixture of sodium hydroxide (NaOH) and sodium silicate (Na2SiO3) solutions. A molarity of 2 M NaOH solution and a fixed alkaline ratio (AR) of 1.5 were used in all mixes. Steel and polyvinyl alcohol (PVA) fibres were employed as monofibres. Steel fibres were added in 0.5%, 0.75%, and 1.00% volume fractions, whereas PVAF were added in 0.15%, 0.30%, and 0.45% volume fractions. In this study, a compressive strength test was performed; furthermore, a uni-axial tension test on reinforced concrete prisms was performed for tensile (first crack load, yield load, tensile stress in concrete, and tension stiffening effect) and cracking (crack spacing and crack width) properties. From the test results, better improvements in compressive strength, first crack load, yield load, tensile stress in concrete, and tension stiffening effect were observed in specimens having 1.00% steel fibres and specimens having 0.30% PVA fibres as monofibres. In the mixes containing 100% GGBFS, there was an improvement in the first crack load of approximately 46% due to 1.00% steel fibres and an approximately 29% improvement due to 0.30% PVA fibres. Furthermore, reduced crack spacings and minimum crack widths were found at 1.00% volume fraction of steel fibres and also in specimens having 0.30% PVA fibres. Overall, this study found that 1.00% steel and 0.3% PVA fibres as monofibres in fly ash-slag-based alkali-activated concrete (FSAAC) were optimal doses in terms of strength and cracking characteristics.
Thunderstorm ground enhancements observed on Aragats mountain in Armenia in the wintertime
Authors: Chilingarian A. , Hovsepyan G. , Aslanyan D. , Karapetyan T. , Sargsyan B. , Svechnikova E. 
Published: August 2023

Abstract
Thunderstorm ground enhancements (TGEs) occur in the spring-autumn seasons at Aragats due to warm air updrafts that cause hydrometeor charging. However, particle detectors recorded three TGEs within 10 hours on February 7, 2023, despite the temperature being −10 °C. Upon analyzing the energy spectra of TGE electrons and gamma rays, it was discovered that the atmospheric electric-field strength above Aragats, at heights 3300–5300 m, could be around 2.1 kV/cm even in winter. We provide details on the fluxes and energy spectra of TGE electrons and gamma rays, as well as discuss models of cloud electrification in winter.