bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desbordando hashtags de Twitter: La protesta digital k-pop en el Paro Nacional de 2021 en Colombia
Authors: Lombana-Bermudez Andres , Rodriguez Gomez Sergio 
Published: July 2023

Este artículo presenta los resultados de un estudio exploratorio y empírico sobre la protesta digital k-pop desplegada durante el Paro Nacional de 2021 en Colombia. Utilizando métodos mixtos y un corpus de 134 144 tuits, se indagó sobre las dinámicas que caracterizan esta forma de activismo político digital y el repertorio de tácticas empleadas por los participantes de esta acción colectiva. Además, por medio de un análisis de contenido multimodal a una muestra aleatoria de 1840 tuits publicados con el hashtag #RepudioAlVándalo, se caracterizaron las imágenes y textos utilizados para controlar el flujo de información y capturar la atención pública en la plataforma digital Twitter. Los resultados de la investigación revelan que las tácticas de resistencia algorítmica, secuestro de hashtags y spam se desplegaron en la acción k-pop de forma efectiva y que consiguieron sabotear los públicos-hashtag que buscaban estigmatizar a los manifestantes y apoyar el uso de la fuerza contra la protesta. A manera de conclusión, se reflexiona sobre la efectividad del movimiento global-local k-pop, la evolución de las tácticas de activismo político digital y su problemática asociación con la terminología de la guerra de la información.
Nondestructive Evaluation of 2 by 10 Southern Pine Lumber
Authors: Uzcategui M. G. C. , França F. J. N. , Seale R. D. , Senalik C. A. , Ross R. J. 
Published: July 2023

Abstract
Efficient use of the available wood resources is necessary to sustainably meet the long-term demand for wood products. This paper presents research about the potential of using transverse and longitudinal vibration techniques to evaluate the bending modulus of elasticity MOE (Eb) and tensile properties (Et and UTS) of 2 by 10 No. 2 grade southern pine (Pinus spp.) lumber. A total of 285 lumber pieces were first nondestructively tested using longitudinal vibration (Director HM 200), transverse vibration (Metriguard E-computer), and proof-loading bending tests (Universal Instron Machine). Each specimen was then destructively tested in tension parallel to the grain to determine tension modulus of elasticity (Et) and ultimate tensile stress (UTS). Correlations between growth characteristics, physical, and mechanical properties were analyzed. Excellent correlative relationships between longitudinal and transverse dMOE with the elastic properties Eb, and Et were found. A strong correlation was also found between the elastic properties Eb and Et. The prediction of Eb was improved after adding density to the model. The estimation of UTS was also improved with the addition of density and a secondary nondestructive measurement. Nondestructive techniques are recommended to assess the mechanical properties of southern pine 2 by 10 lumber.
Assessing Income and Risk of Incorporating Pine Straw Production into Slash Pine Plantations
Authors: McConnell T. Eric 
Published: July 2023

Abstract
Slash pine plantation economic returns from both timber and pine straw producing perspectives were compared. Bare land values (BLVs) were calculated for site index 65 (base age 25) across three discount rates (4%, 5%, and 6%), three planting densities [545 (8 by 10 ft), 623 (7 by 10 ft), and 726 (6 by 10 ft) trees per acre], and two sets of timber prices (30-year and 10-year averages). Timber yields were obtained from the Cutover Slash Growth and Yield Simulator. Straw yields were estimated stochastically using a two-parameter Weibull distribution based on findings from a summary of pine straw yields and economic benefits in loblolly, longleaf, and slash pine stands. Straw production at an estimated average of 198 bales per acre (13 by 13 by 26 inches) improved net economic returns across all discount rates and planting densities. Increasing discount rates expectedly lowered BLVs. The BLVs varied much less across spacings, with planting at 7 by 10 ft being the preferred option. From 159 to 164 bales per acre were needed for pine straw operations to break even when planting 623 trees per acre depending on the discount rate. The distance from the average BLV to the 90th percentile was greater than the distance from the average BLV to the 10th percentile across strategies. This implied a greater potential existed for pine straw harvesting to improve BLV, but risk associated with a pine straw enterprise could reduce net income levels below simply choosing to forgo this activity.
Evaluating a novel patient pathway to manage symptomatic breast referrals (the blue flag clinic): a longitudinal observational study
Authors: Hubbard TJE , Liu X , Sulieman M , Drew P , Brown I , English R , Abbas I , Potiszil K , Barta M , Jackson N , King P 
Published: July 2023

Introduction A novel referral pathway for exhibited breast symptom (EBS) referrals to manage increasing referrals of urgent suspected cancer (USC) was implemented in our trust. We report on the safety and effect on compliance with the 2-week-wait rule (2WW). Methods A single-centre longitudinal observational study included all patients referred to a UK breast unit during 13 May 2019 to 27 March 2020 (period 1) and 8 February 2021 to 31 January 2022 (period 2). USC referrals were assessed in a one-stop clinic (red flag clinic [RFC]); EBS referrals were assessed in a new clinic in which clinical evaluation was performed and imaging occurred subsequently (blue flag clinic [BFC]). Patients were followed up to determine the symptomatic interval cancer rate. Results There were 9,695 referrals; 1,655 referrals (17%) were assessed in the BFC after 63 exclusions. Some 95.9% of patients had a benign clinical examination (P1/P2), 80.1% had imaging (mammogram or ultrasound) and 4% had a tissue biopsy. In total, 16/1,655 (0.97%) BFC patients and 510/7,977 (8.2%) RFC patients were diagnosed with breast cancer (breast cancer detection rate). Some 1,631 patients (with 1,639 referrals) were discharged and followed up for a median of 17 months (interquartile range 12–32) with one subsequent cancer diagnosis (symptomatic interval cancer rate, 0.06%). Implementation of the BFC pathway increased 3-month average trust performance of USC referrals with 2WW standard from 8.5% to 98.7% (period 1) and from 30% to 66% (period 2). Conclusions The BFC pathway for EBS patients is safe and implementation led to improvement against the 2WW target for USC referrals, ensuring resources are prioritised to patients with the highest likelihood of breast cancer.
Accuracy and intrasession variability of noncycloplegic autorefraction of school-aged children and adolescents
Authors: Kiermasz Justyna , Pniewski Jacek 
Published: July 2023

The aims of the study were (1) to compare the accuracy and intrasession variability of noncycloplegic autorefraction (AR) obtained by a photorefractor and conventional and open-field autorefractors and (2) to evaluate the impact of accommodative and binocular vision anomalies on the accuracy of autorefraction. Twenty-nine children and adolescents aged 8–18 years were examined. All instruments gave more myopic results than subjective refraction (SR). Mean differences between the SR and the AR were +0.52/−0.25×96∘ for the photorefractor, +0.63/−0.31×93∘ for the conventional autorefractor, and +0.19/−0.26×94∘ for the open-field instrument. The photorefractor appeared to be the most repeatable. The impact of the examined vision anomalies on the accuracy of autorefraction was not statistically significant.
Continuous and early prediction of future moderate and severe Acute Kidney Injury in critically ill patients: Development and multi-centric, multi-national external validation of a machine-learning model
Authors: Alfieri Francesca , Ancona Andrea , Tripepi Giovanni , Rubeis Andrea , Arjoldi Niccolò , Finazzi Stefano , Cauda Valentina , Fagugli Riccardo Maria 
Published: July 2023

Background
Acute Kidney Injury (AKI) is a major complication in patients admitted to Intensive Care Units (ICU), causing both clinical and economic burden on the healthcare system. This study develops a novel machine-learning (ML) model to predict, with several hours in advance, the AKI episodes of stage 2 and 3 (according to KDIGO definition) acquired in ICU.

Methods
A total of 16’760 ICU adult patients from 145 different ICU centers and 3 different countries (US, Netherland, Italy) are retrospectively enrolled for the study. Every hour the model continuously analyzes the routinely-collected clinical data to generate a new probability of developing AKI stage 2 and 3, according to KDIGO definition, during the ICU stay.

Results
The predictive model obtains an auROC of 0.884 for AKI (stage 2/3 KDIGO) prediction, when evaluated on the internal test set composed by 1’749 ICU stays from US and EU centers. When externally tested on a multi-centric US dataset of 6’985 ICU stays and multi-centric Italian dataset of 1’025 ICU stays, the model achieves an auROC of 0.877 and of 0.911, respectively. In all datasets, the time between model prediction and AKI (stage 2/3 KDIGO) onset is at least of 14 hours after the first day of ICU hospitalization.

Conclusions
In this study, a novel ML model for continuous and early AKI (stage 2/3 KDIGO) prediction is successfully developed, leveraging only routinely-available data. It continuously predicts AKI episodes during ICU stay, at least 14 hours in advance when the AKI episode happens after the first 24 hours of ICU admission. Its performances are validated in an extensive, multi-national and multi-centric cohort of ICU adult patients. This ML model overcomes the main limitations of currently available predictive models. The benefits of its real-world implementation enable an early proactive clinical management and the prevention of AKI episodes in ICU patients. Furthermore, the software could be directly integrated with IT system of the ICU.
Patient experience in community health services and first choice for medical attention: A cross-sectional study in Wuhan, China
Authors: Tang Changmin , Fang Pengqian , Bai Xue , Min Rui , Liu Chaojie 
Published: July 2023

Objectives
In China, it is up to the patients to choose between hospitals and primary care facilities to initiate their medical care. This study aimed to determine the association between patient experience with community health centres (CHCs, a predominant provider of community-based primary care) and patient preference of taking community-based primary care facilities as a first choice for medical attention.

Methods
A questionnaire survey was conducted on 1919 patients who sought medical care in 55 CHCs in Wuhan, China. Respondents were asked to identify their preferred first choice for medical attention and rate their satisfaction with eight aspects of CHCs (basic facility, medical equipment, medical services, nursing services, treatment process, courtesy and responsiveness, time spent with medical doctor, pharmacy services). Multivariate logistic regression models were established to determine the association between the CHC experience and the first choice of providers after adjustment for variations in sociodemographic characteristics.

Results
Over 90% of respondents were satisfied or very satisfied with the eight aspects of CHCs; but only 75% preferred to take community-based primary care facilities as their first choice for medical attention. Those who were older and had a lower income were more likely to choose community-based primary care facilities. Geographic proximity and higher levels of satisfaction with the basic facility, courtesy and responsiveness, and pharmacy services in the CHCs were associated with a higher likelihood of taking community-based primary care facilities as a first choice for medical attention.

Conclusion
The consumers of CHCs are generally satisfied with the services they received. However, one quarter of the CHC patients are yet to be convinced to accept community-based primary care facilities as a preferred first provider for medical care. Geographic proximity and patient experience with CHCs are associated with the patient choice.
Intraperitoneal transplant of Hepatocytes co-Encapsulated with mesenchymal stromal cells in modified alginate microbeads for the treatment of acute Liver failure in Pediatric patients (HELP)—An open-label, single-arm Simon’s two stage phase 1 study protocol
Authors: Fitzpatrick Emer , Filippi Celine , Jagadisan Barath , Shivapatham Dharshene , Anand Hanish , Lyne Mike , Stroud Katherine-Daisy , Newton Rebecca , DeLord Marc , Douiri Abdel , Dhawan Anil 
Published: July 2023

Background
Pediatric acute liver failure (PALF) carries a high mortality without liver transplantation (LT) in children. Liver transplantation, though lifesaving, is limited by timely donor organ availability, the risks of major surgery and complications of life-long immunosuppression. Hepatocyte transplantation (HT) improves synthetic and detoxification functions in small animal models. The encapsulation of hepatocytes in alginate protects it from the recipient immune system while the intraperitoneal route of administration allows large volumes to be infused. The safety and possibly short-term efficacy of encapsulated hepatocytes has been observed in a named patient use. A novel type of microbeads (HMB002) has been developed, using a modified alginate and mesenchymal stromal cells (MSCs). Its safety and medium-term efficacy need to be studied in the context of clinical study while optimizing the hepatocyte function and viability using modifications of the alginate and MSCs co-encapsulation.

Methods
A single centre, non-randomised, open-label, single-arm Simon’s two stage study will be conducted to evaluate the safety, biological activity and tolerability of transplantation of a single intraperitoneal dose of microbeads made from an optimum combination of a modified alginate, MSCs and hepatocytes in 17 patients less than 16 years of age with acute liver failure (Stage 1: 9 patients and Stage 2: 8 patient). Safety will be assessed by documenting moderate to severe (including life threatening and death) adverse events due to HMB002 in the first 52 weeks post-procedure. Tolerability will be assessed by observing the proportion of initiated infusions where >80% of infusion is received by the patient. Biological activity will be reflected in patient survival with native liver at 24 weeks post treatment.

Discussion
HMB002, if safe and efficacious in acute liver failure, could be a bridge until the liver regenerates or a suitable organ becomes available. There are multiple advantages to using HT. HT, when delivered by the intraperitoneal route, is less invasive than LT. Hepatocytes from a single donor liver can be used to treat multiple patients. Cryopreserved cells provide an off-the-shelf emergency treatment in PALF. When encapsulated, alginate encapsulation of hepatocytes precludes the need for immunosuppression unlike in LT.
Universal screening or a universal risk assessment combined with risk-based screening for multidrug-resistant microorganisms upon admission: Comparing strategies
Authors: van der Schoor Adriënne S. , Severin Juliëtte A. , Klaassen Corné H. W. , van den Akker Johannes P. C. , Bruno Marco J. , Hendriks Johanna M. , Vos Margreet C. , Voor in ‘t holt Anne F. 
Published: July 2023

Objective
Timely identification of patients who carry multidrug-resistant microorganisms (MDRO) is needed to prevent nosocomial spread to other patients and to the hospital environment. We aimed to compare the yield of a universal screening strategy upon admission to the currently installed universal risk assessment combined with risk-based screening upon admission.

Methods
This observational study was conducted within a prospective cohort study. From January 1, 2018, until September 1, 2019, patients admitted to our hospital were asked to participate. Nasal and perianal samples were taken upon admission and checked for the presence of MDRO. The results of the universal risk assessment and risk-based screening were collected retrospectively from electronic health records.

Results
In total, 1017 patients with 1069 separate hospital admissions participated in the study. Universal screening identified 38 (3.6%) unknown MDRO carriers upon admission (37 individual patients), all carrying extended-spectrum beta-lactamase-producing Enterobacterales. For 946 of 1069 (88.5%) patients, both the universal risk assessment and universal screening were performed. For 19 (2.0%) admissions, ≥1 risk factor was identified. The universal risk assessment identified one (0.1%) unknown carrier, compared to 37 out of 946 carriers for the universal screening (P<0.001). Of the 37 carriers identified through the universal screening, 35 (94.6%) reported no risk factors.

Conclusions
Our results show that in our low endemic setting, a universal screening strategy identified significantly more MDRO carriers than the currently implemented universal risk-assessment. When implementing a universal risk-assessment, risk factors should be carefully selected to be able to identify ESBL-E carriers. While the universal screening identified more MDRO carriers, further research is needed to determine the cost-effectiveness of this strategy.
Clinical and genetic features of 334 Asian patients with Birt–Hogg–Dubé syndrome (BHDS) who presented with pulmonary cysts with or without a history of pneumothorax, with special reference to BHDS-associated pneumothorax
Authors: Namba Yukiko , Ebana Hiroki , Okamoto Shouichi , Kobayashi Etsuko , Kurihara Masatoshi , Sekimoto Yasuhito , Tsuboshima Kenji , Okura Makiko Kunogi , Mitsuishi Yoichiro , Takahashi Kazuhisa , Seyama Kuniaki 
Published: July 2023

BackgroundThe clinical pulmonary manifestations and genetic features of Birt–Hogg–Dubé syndrome (BHDS) in Asian patients remained unclear. We aimed to clarify the clinical features of BHDS-associated pneumothorax (PTX) and retrospectively investigate potential contributing factors in the largest Asian cohort to date.MethodsWe reviewed the clinical and genetic data collected in 2006–2017, from the BHDS patients who were Asian and presented with pulmonary cysts with or without a history of PTX.ResultsData from 334 (41.3% males; 58.7% females) patients from 297 unrelated families were reviewed. Among them, 314 (94.0%) patients developed PTX. The median age at the first occurrence of PTX was 32 years, which was significantly lower in males (P= 0.003) and patients without notable skin manifestations (P< 0.001). Seventy-six (24.2%) patients experienced their first PTX episode before the age of 25 years. PTX simultaneously occurred in the bilateral lungs of 37 (11.8%) patients. Among 149 patients who had their first PTX episode at least 10 years before BHDS diagnosis, PTX occurred more frequently in males (P= 0.030) and light smokers than in nonsmokers (P= 0.014). The occurrence of PTX peaked in the early 30s and gradually decreased with age but remained high in females (P= 0.001). We identified 70 uniqueFLCNgermline variants, including duplications (46.4%), substitutions (7.1%), insertions/deletions (30.0%), and variants affecting splicing (12.5%). Approximately 80% of Asian patients suspected of having BHDS could be genetically diagnosed by examiningFLCNexons 7, 9, 11, 12, and 13. No apparent genotype–phenotype correlation regarding pulmonary manifestations was identified.ConclusionsOur findings indicate that sex, smoking history, and skin manifestations at BHDS diagnosis significantly influence the clinical features of BHDS-associated PTX. These findings may contribute to the appropriate management and treatment of BHDS-associated PTX.
Rapidly Progressive Portal Cavernoma Cholangiopathy in a Patient With Infeasible Decompressive Shunt Surgery
Authors: Nadinskaia Maria Yu , Ivashkin Vladimir T. , Nekrasova Tatiana Р. , Novruzbekov Murad S. , Zimina Larisa N. , Kodzoeva Khava B. , Strelkova Daria A. 
Published: July 2023

ABSTRACT
We present a 27-year-old man with a 2-year history of extrahepatic portal vein obstruction and selective immunoglobulin A deficiency, referred for acute cholangitis from portal cavernoma cholangiopathy (PCC). Because recurrent cholangitis rapidly led to liver failure, orthotopic liver transplantation (OLT) was successfully performed. To date, this is one of the few cases of patients with symptomatic PCC who required OLT and the first case who had a successful 6-year follow-up. Thus, OLT can be used for symptomatic PCC associated with nonshuntable anatomy, ineffective biliary drainage, and progressive liver damage. Selective immunoglobulin A deficiency may play a role in recurrent cholangitis.
The Effect of Wages on Human Capital and its Virtuous Dynamic Cycle
Authors: Lartigue Mendoza Jacques , Domínguez Salomón 
Published: July 2023

This paper provides economic theory with a dynamic structural model that mathematically proves both a positive effect of wages on the workers’ human capital intertemporal investment decisions and the existence of a virtuous dynamic cycle between wages and human capital.Among the desired characteristics of the proposed model is that it has an analytical solution, permitting the achievement of an optimal decision rule for each choice variable and the calibration of its parameters using observed data; this favors an easy implementation by policymakers and researchers. The constructed statistics and the results of the empirical application of the model, to the Mexican developing economy, support the mathematical conclusions. The model predicts two benchmark human capital gross returns and their corresponding wages, by levels of education. Below the second one, human capital coming from formal education vanishes over time, due to investment not being enough to offset its depreciation; below the first one, workers stop investing in education. Unfortunately, around 40% and 20% of Mexican workers are located below them, respectively.
The rise and fall of the phlogiston theory: a tool to explain the use of models in science education
Authors: Mamlok-Naaman Rachel 
Published: July 2023

Abstract
The phlogiston theory was established around 1700 and lasted for about one hundred years. According to the Phlogiston Theory, phlogiston is released during heating processes, and the remaining material becomes lighter. The demise of this theory started with Lavoisier’s new insights into the phenomena of chemical reactions in general and combustion in particular, as well as about the composition of air. The rise and fall of the Phlogiston theory is a good example to the process of the replacement of one theory by another, due to new facts and new discoveries. In addition, it stresses the advantages and limitations of scientific models and theories, as well as the nature of science. A brief program, planned for two lessons, was developed around the Phlogiston Theory, in the framework of teaching and learning the “Science: An Ever-Developing Entity” program. Semi-structured interviews with teachers and students were conducted after the completion of the Phlogiston topic. Based on the findings, it is suggested that the brief program, reached its goals. The students, who studied the program, learned more about the scientists – their curiosity and their boldness, as well as about the scientific endeavor, consisting of discoveries, models and theories.
Diagonal restriction of Eisenstein series and Kudla–Millson theta lift
Authors: Branchereau Romain 
Published: July 2023

Abstract
We consider the Kudla–Millson theta series associated to a quadratic space of signature

(
N
,
N
)

{(N,N)}

. By combining a “see-saw” argument with the Siegel–Weil formula, we show that its (regularized) integral along a torus attached to a totally real field of degree N is the diagonal restriction of an Eisenstein series. It allows us to express the Fourier coefficients of the diagonal restriction as intersection numbers, which generalizes a result of Darmon, Pozzi and Vonk to totally real fields.