bluuebunny/crossref_metadata_2025_split huggingface dataset:
Some concerns about the idea of basic moral certainty: A critical response to Samuel Laves
Authors: Fairhurst Jordi 
Published: June 2023

AbstractPleasants has developed the idea of basic moral certainties. Analogous to Wittgenstein's basic empirical certainties, they are best described as universal moral certainties which are natural and nonpropositional, and show unreflectively in the way we act. A clear‐cut example is the wrongness of killing innocent human beings. Philosophers have levelled three damaging criticisms against Pleasants' proposal by (i) offering counterexamples to his proposed example of moral certainty, (ii) highlighting some disanalogies between moral certainties and Wittgenstein's basic empirical certainties and, lastly, (iii) showing the lack of arguments and evidence offered by Pleasants to substantiate the claim that moral certainties are natural. To address these criticisms, Laves has revised Pleasants' proposal by providing numerous amendments. In this paper, I develop some concerns about Laves' proposed amendments and indicate that, at present, they are unable to fully overcome the criticisms levelled against the idea of basic moral certainty. Whether Laves' proposal can escape these troubles demands further attention.
Determinants of alcohol use among young males in two Indian states: A population‐based study
Authors: Heijdra Suasnabar Jan M. , Nadkarni Abhijit , Palafox Benjamin 
Published: June 2023

AbstractObjectivesThere is insufficient evidence about the determinants of alcohol use amongst young people in India and other low‐and middle‐income countries, despite alcohol's high contribution to disease burden and increasing consumption in this population. We aimed to identify and estimate the determinants of alcohol use in a representative sample of 2716 young men from Bihar and Uttar Pradesh who participated in the ‘Understanding the Lives of Adolescents and Young Adults’ (UDAYA) study.MethodsFirst, we developed an exploratory conceptual framework of potential alcohol use determinants in the study settings based on available literature. We then estimated the effects of 35 potential alcohol use determinants identified in the conceptual framework (including 14 latent factors identified through exploratory factor analysis) on any alcohol use in the past 3 years and regular alcohol use amongst past three‐year drinkers, using mixed‐effects logistic models. The determinants explored were operationalised using longitudinal data from the UDAYA study.ResultsOur adjusted models identified 18 determinants for past 3‐year alcohol use and 12 determinants for regular use. Distal determinants (e.g., socioeconomic status), intermediate determinants (e.g., parental alcohol use, media use), and proximal determinants (e.g., emotional regulation, early tobacco use) were identified. Geographical variations in both outcomes indicate potential differences in unmeasured community‐level determinants (e.g., alcohol availability and acceptability).ConclusionsOur findings extend the generalizability of several known determinants across settings, yet highlight the importance of addressing alcohol use in young people as a complex and context‐dependent issue. Many identified determinants (e.g., education, media use, poor parental support, early tobacco use) are amenable to intervention through multi‐sectoral prevention programs/policies. Such determinants should be the focus of ongoing policy/intervention development efforts in the region, and our revised conceptual framework may inform further research in India or similar South Asian settings.
Embryo sac development relies on symplastic signals from ovular integuments in Arabidopsis
Authors: Qin Zheng , Liang Zi‐Zhen , Wu Ya‐Nan , Zhou Xue‐Qing , Xu Meng , Jiang Li‐Wen , Li Sha , Zhang Yan 
Published: June 2023

SUMMARYOvules are female reproductive organs of angiosperms, consisting of sporophytic integuments surrounding female gametophytes, that is, embryo sacs. Synchronization between integument growth and embryo sac development requires intracellular communication. However, signaling routes through which cells of the two generations communicate are unclear. We report that symplastic signals through plasmodesmata (PDs) of integuments are critical for the development of female gametophytes. Genetic interferences of PD biogenesis either by functional loss of CHOLINE TRANSPORTER‐LIKE1 (CTL1) or by integument‐specific expression of a mutated CALLOSE SYNTHASE 3 (cals3m) compromised PD formation in integuments and reduced fertility. Close examination of pINO:cals3m or ctl1 ovules indicated that female gametophytic development was either arrested at various stages after the formation of functional megaspores. In both cases, defective ovules could not attract pollen tubes, leading to the failure of fertilization. Results presented here demonstrate a key role of the symplastic route in sporophytic control of female gametophytic development.
Modulation of the functional interfaces between retroviral intasomes and the human nucleosome
Authors: Mauro E. , Lapaillerie D. , Tumiotto C. , Charlier C. , Martins F. , Sousa S. F. , Métifiot M. , Weigel P. , Yamatsugu K. , Kanai M. , Munier-Lehmann H. , Richetta C. , Maisch M. , Dutrieux J. , Batisse J. , Ruff M. , Delelis O. , Lesbats P. , Parissi V. 
Published: June 2023

ABSTRACT

Infection by retroviruses as HIV-1 requires the stable integration of their genome into the host cells. This process needs the formation of integrase (IN)-viral DNA complexes, called intasomes, and their interaction with the target DNA wrapped around nucleosomes within cell chromatin. To provide new tools to analyze this association and select drugs, we applied the AlphaLISA technology to the complex formed between the prototype foamy virus (PFV) intasome and nucleosome reconstituted on 601 Widom sequence. This system allowed us to monitor the association between both partners and select small molecules that could modulate the intasome/nucleosome association. Using this approach, drugs acting either on the DNA topology within the nucleosome or on the IN/histone tail interactions have been selected. Within these compounds, doxorubicin and histone binders calixarenes were characterized using biochemical,
in silico
molecular simulations and cellular approaches. These drugs were shown to inhibit both PFV and HIV-1 integration
in vitro
. Treatment of HIV-1-infected PBMCs with the selected molecules induces a decrease in viral infectivity and blocks the integration process. Thus, in addition to providing new information about intasome-nucleosome interaction determinants, our work also paves the way for further unedited antiviral strategies that target the final step of intasome/chromatin anchoring.

IMPORTANCE

In this work, we report the first monitoring of retroviral intasome/nucleosome interaction by AlphaLISA. This is the first description of the AlphaLISA application for large nucleoprotein complexes (>200 kDa) proving that this technology is suitable for molecular characterization and bimolecular inhibitor screening assays using such large complexes. Using this system, we have identified new drugs disrupting or preventing the intasome/nucleosome complex and inhibiting HIV-1 integration both
in vitro
and in infected cells. This first monitoring of the retroviral/intasome complex should allow the development of multiple applications including the analyses of the influence of cellular partners, the study of additional retroviral intasomes, and the determination of specific interfaces. Our work also provides the technical bases for the screening of larger libraries of drugs targeting specifically these functional nucleoprotein complexes, or additional nucleosome-partner complexes, as well as for their characterization.
Planar degeneracy of the three-gluon vertex
Authors: Aguilar A. C. , Ferreira M. N. , Papavassiliou J. , Santos L. R. 
Published: June 2023

AbstractWe present a detailed exploration of certain outstanding features of the transversely-projected three-gluon vertex, using the corresponding Schwinger–Dyson equation in conjunction with key results obtained from quenched lattice simulations. The main goal of this study is the scrutiny of the approximate property denominated “planar degeneracy”, unveiled when the Bose symmetry of the vertex is properly exploited. The planar degeneracy leads to a particularly simple parametrization of the vertex, reducing its kinematic dependence to essentially a single variable. Our analysis, carried out in the absence of dynamical quarks, reveals that the planar degeneracy is particularly accurate for the description of the form factor associated with the classical tensor, for a wide array of arbitrary kinematic configurations. Instead, the remaining three form factors display considerable violations of this property. In addition, and in close connection with the previous point, we demonstrate the numerical dominance of the classical form factor over all others, except in the vicinity of the soft-gluon kinematics. The final upshot of these considerations is the emergence of a very compact description for the three-gluon vertex in general kinematics, which may simplify significantly nonperturbative applications involving this vertex.
Automation of the Timed Up and Go Test Using a Doppler Radar System for Gait and Balance Analysis in Elderly People
Authors: Soubra Racha , Mourad-Chehade Farah , Chkeir Aly 
Published: June 2023

The timed up and go (TUG) test is a simple, valid, and reliable clinical tool that is widely used to assess mobility in elderly people. Several research studies have been conducted to automate the TUG test using wearable sensors or motion-tracking systems. Despite their promising results, the adopted technological systems present inconveniences in terms of acceptability and privacy protection. In this work, we propose to overcome these problems by using a Doppler radar system set into the backrest of a chair in order to automate the TUG test and extract additional information from its phases (i.e., transfer, walk, and turn). We intend to segment its phases and extract spatiotemporal gait parameters automatically. Our methodology is mainly based on a multiresolution analysis of radar signals. We proposed a segmentation technique based on the extraction of limbs oscillations signals through a semisupervised machine learning approach, on the one hand, and the application of the DARC algorithm on the other hand. Once the speed signals of torso and limbs oscillations were detected, we suggested estimating 14 gait parameters. All our approaches were validated by comparing outcomes to those obtained from a reference Vicon system. High correlation coefficients were obtained by comparing the speed signals of the torso

ρ
=
0.8

, the speed signals of limbs oscillations

ρ
=
0.91

, the initial and final indices of TUG phases

ρ
=
0.95

, and the extracted parameters

p
e
r
c
e
n
t
a
g
e

e
r
r
o
r
<
4.8

obtained after radar signal processing to those obtained from the Vicon system.
Mortality in Patients Hospitalized With Acute Myocardial Infarction Without Standard Modifiable Risk Factors: The ARIC Study Community Surveillance
Authors: Chunawala Zainali S. , Caughey Melissa C. , Bhatt Deepak L. , Hendrickson Michael , Arora Sameer , Bangalore Sripal , Erwin John P. , Levisay Justin P. , Rosenberg Jonathan R. , Ricciardi Mark J. , Blankstein Ron , Matsushita Kunihiro , Smith Sidney , Qamar Arman 
Published: June 2023

Background
Prevention strategies targeting standard modifiable cardiovascular risk factors (SMuRFs; diabetes, hypertension, smoking, hypercholesterolemia) are critical to improving cardiovascular disease outcomes. However, acute myocardial infarction (AMI) among individuals who lack 1 or more SMuRFs is not uncommon. Moreover, the clinical characteristics and prognosis of SMuRFless individuals are not well characterized.

Methods and Results
We analyzed AMI hospitalizations from 2000 to 2014 captured by the ARIC (Atherosclerosis Risk in Community) study community surveillance. AMI was classified by physician review using a validated algorithm. Clinical data, medications, and procedures were abstracted from the medical record. Main study outcomes included short‐ and long‐term mortality within 28 days and 1 year of AMI hospitalization. Between 2000 and 2014, a total of 742 (3.6%) of 20 569 patients with AMI were identified with no documented SMuRFs. Patients without SMuRFs were less likely to receive aspirin, nonaspirin antiplatelet therapy, or beta blockers and less often underwent angiography and revascularization. Compared with those with one or more SMuRFs, patients without SMuRFs had significantly higher 28‐day (odds ratio, 3.23 [95% CI, 1.78–5.88]) and 1‐year (hazard ratio, 2.09 [95% CI, 1.29–3.37]) adjusted mortality. When examined across 5‐year intervals from 2000 to 2014, the incidence of 28‐day mortality significantly increased for patients without SMuRFs (7% to 15% to 27%), whereas it declined for those with 1 or more SMuRFs (7% to 5% to 5%).

Conclusions
Individuals without SMuRFs presenting with AMI have an increased risk of all‐cause mortality with an overall lower prescription rate for guideline‐directed medical therapy. These findings highlight the need for evidence‐based pharmacotherapy during hospitalization and the need to discover new markers and mechanisms for early risk identification in this population.
Risk of Cardiovascular Disease After COVID‐19 Diagnosis Among Adults With and Without Diabetes
Authors: Koyama Alain K. , Imperatore Giuseppina , Rolka Deborah B. , Lundeen Elizabeth , Rutkowski Rachel E. , Jackson Sandra L. , He Siran , Kuklina Elena V. , Park Soyoun , Pavkov Meda E. 
Published: June 2023

Background
Growing evidence suggests incident cardiovascular disease (CVD) may be a long‐term outcome of COVID‐19 infection, and chronic diseases, such as diabetes, may influence CVD risk associated with COVID‐19. We evaluated the postacute risk of CVD >30 days after a COVID‐19 diagnosis by diabetes status.

Methods and Results
We included adults ≥20 years old with a COVID‐19 diagnosis from March 1, 2020 through December 31, 2021 in a retrospective cohort study from the IQVIA PharMetrics Plus insurance claims database. A contemporaneous control group comprised adults without recorded diagnoses for COVID‐19 or other acute respiratory infections. Two historical control groups comprised patients with or without an acute respiratory infection. Cardiovascular outcomes included cerebrovascular disorders, dysrhythmia, inflammatory heart disease, ischemic heart disease, thrombotic disorders, other cardiac disorders, major adverse cardiovascular events, and any CVD. The total sample comprised 23 824 095 adults (mean age, 48.4 years [SD, 15.7 years]; 51.9% women; mean follow‐up, 8.5 months [SD, 5.8 months]). In multivariable Cox regression models, patients with a COVID‐19 diagnosis had a significantly greater risk of all cardiovascular outcomes compared with patients without a diagnosis of COVID‐19 (hazard ratio [HR], 1.66 [1.62–1.71], with diabetes; HR, 1.75 [1.73–1.78], without diabetes). Risk was attenuated but still significant for the majority of outcomes when comparing patients with COVID‐19 to both historical control groups.

Conclusions
In patients with COVID‐19 infection, postacute risk of incident cardiovascular outcomes is significantly higher than among controls without COVID‐19, regardless of diabetes status. Therefore, monitoring for incident CVD may be essential beyond the first 30 days after a COVID‐19 diagnosis.
Assessing learning about food safety using Personal Meaning Maps
Authors: Silva Alexandre , Junqueira Luís , Truninger Mónica , Delicado Ana , Csenki Eszter , Fehér Ágnes , Ózsvári László , Szakos Dávid 
Published: June 2023

Objective: According to the World Health Organisation’s estimates, food contamination is linked to 23 million cases of illness and 5,000 deaths per year in Europe. While changes in food production and distribution play an important role in managing contamination risk, foodborne illnesses can originate in food-handling practices at home. This study aimed to assess how a food safety education initiative in which students learned about food safety risks and minimising risk behaviour improved students’ knowledge about food safety. Setting: Three public schools, two in Hungary and one in Portugal. Methods: A study of 105 Hungarian and Portuguese students between 11 and 18 years of age were invited to prepare Personal Meaning Maps before and after the delivery of a food safety lesson delivered by a school science teacher. Knowledge and risk perceptions of food safety, before and after the delivery of the lesson, were assessed both quantitatively and qualitatively. Results: Food safety topics that were scored highest were those that already had strong scores in the diagnostic phase, such as those related to personal hygiene and use-by dates. However, the largest increases in mastery scores were in less-known-about topics such as cold chain and cross-contamination risks. Idea associations take place often by linking specific contents to already-known-about concepts. Conclusion: Findings show that students more readily engaged with practical concepts directly linked to their experience of food handling at home than to more abstract concepts of food safety and contamination.
Screws or Sutures? A Pediatric Cadaveric Study of Tibial Spine Fracture Repairs
Authors: Johnstone Thomas M. , Baird David W. , Cuellar-Montes Annelisse , van Deursen Willemijn Hendrike , Tompkins Marc , Ganley Theodore J. , Yen Yi-Meng , Ellis Henry B. , Chan Calvin K. , Green Daniel W. , Sherman Seth L. , Shea Kevin G. 
Published: June 2023

Background: Tibial spine fractures are common in the pediatric population because of the biomechanical properties of children’s subchondral epiphyseal bone. Most studies in porcine or adult human bone suggest that suture fixation performs better than screw fixation, but these tissues may be poor surrogates for pediatric bone. No previous study has evaluated fixation methods in human pediatric knees. Purpose: To quantify the biomechanical properties of 2-screw and 2-suture repair of tibial spine fracture in human pediatric knees. Study Design: Controlled laboratory study. Methods: Cadaveric specimens were randomly assigned to either 2-screw or 2-suture fixation. A standardized Meyers-Mckeever type 3 tibial spine fracture was induced. Screw-fixation fractures were reduced with two 4.0-mm cannulated screws and washers. Suture-fixation fractures were reduced by passing 2 No. 2 FiberWire sutures through the fracture fragment and the base of the anterior cruciate ligament. Sutures were secured through bony tunnels over a 1-cm tibial cortical bridge. Each specimen was mounted at 30° of flexion. A cyclic loading protocol was applied to each specimen, followed by a load-to-failure test. Outcome measures were ultimate failure load, stiffness, and fixation elongation. Results: Twelve matched pediatric cadaveric knees were tested. Repair groups had identical mean (8.3 years) and median (8.5 years) ages and an identical number of samples of each laterality. Ultimate failure load did not significantly differ between screw (mean ± SD, 143.52 ± 41.9 7 N) and suture (135.35 ± 47.94 N) fixations ( P = .760). Screws demonstrated increased stiffness and decreased elongation, although neither result was statistically significant at the .05 level (21.79 vs 13.83 N/mm and 5.02 vs 8.46 mm; P = .076 and P = .069, respectively). Conclusion: Screw fixation and suture fixation of tibial spine fractures in human pediatric tissue were biomechanically comparable. Clinical Relevance: Suture fixations are not biomechanically superior to screw fixations in pediatric bone. Pediatric bone fails at lower loads, and in different modes, compared with adult cadaveric bone and porcine bone. Further investigation into optimal repair is warranted, including techniques that may reduce suture pullout and “cheese-wiring” through softer pediatric bone. This study provides new biomechanical data regarding the properties of different fixation types in pediatric tibial spine fractures to inform clinical management of these injuries.
Does the clot burden as assessed by the Mean Bilateral Proximal Extension of the Clot score reflect mortality and adverse outcome after pulmonary embolism?
Authors: Gleditsch Jostein , Jervan Øyvind , Klok Frederikus A , Holst René , Hopp Einar , Tavoly Mazdak , Ghanima Waleed 
Published: June 2023

Background Rapid diagnosis and risk stratification are important to reduce the risk of adverse clinical events and mortality in acute pulmonary embolism (PE). Although clot burden has not been consistently shown to correlate with disease outcomes, proximally located PE is generally perceived as more severe. Purpose To explore the ability of the Mean Bilateral Proximal Extension of the Clot (MBPEC) score to predict mortality and adverse outcome. Methods This was a single center retrospective cohort study. 1743 patients with computed tomography pulmonary arteriography (CTPA) verified PE diagnosed between 2005 and 2020 were included. Patients with active malignancy were excluded. The PE clot burden was assessed with MBPEC score: The most proximal extension of PE was scored in each lung from 1 = sub-segmental to 4 = central. The MBPEC score is the score from each lung divided by two and rounded up to nearest integer. Results We found inconsistent associations between higher and lower MBPEC scores versus mortality. The all-cause 30-day mortality of 3.9% (95% CI: 3.0–4.9). The PE-related mortality was 2.4% (95% CI: 1.7–3.3). Patients with MBPEC score 1 had higher all-cause mortality compared to patients with MBPEC score 4: Crude Hazard Ratio (cHR) was 2.02 (95% CI: 1.09–3.72). PE-related mortality was lower in patients with MBPEC score 3 compared to score 4: cHR 0.22 (95% CI: 0.05–0.93). Patients with MBPEC score 4 did more often receive systemic thrombolysis compared to patients with MBPEC score 1–3: 3.2% vs. 0.6% ( p < .001). Patients with MBPEC score 4 where more often admitted to the intensive care unit: 13% vs. 4.7% ( p < .001). Conclusion We found no consistent association between the MBPEC score and mortality. Our results therefore indicate that peripheral PE does not necessarily entail a lower morality risk than proximal PE.