bluuebunny/crossref_metadata_2025_split huggingface dataset:
El reto juridico de trascender la justicia retributiva e incorporar la justicia restaurativa en Mèxico
Authors: Lamas Meza Saul Adolfo , Miranda Camarena Adrián Joaquín 
Published: June 2023

: Nuestra sociedad actual ha alcanzado parámetros de violencia alarmantes, la criminalidad ha permeado progresivamente en la sociedad, situación que se ha tornado en un gran reto para el Estado y su aparato de gobierno. Debido a este contexto coyuntural en el año 2008 se materializó en México un cambio en la forma de concebir el derecho procesal penal, la Constitución Mexicana fue reformada en múltiples numerales para erigir un modelo de corte acusatorio, abandonando con ello el otrora sistema tradicional inquisitivo; la razón ontológica de esta nueva maquinaria procesal buscaba dinamizar el proceso penal, eficientando sus operaciones y tornándolo más garantista, por ello para coadyuvar con este propósito la carta Magna incorporó aparejadamente a la Justicia Alternativa y sus mecanismos de resolución de controversias, figuras que si logran afianzarse con autonomía operativa y con una estructura orgánica sólida, darán paso a la implementación genuina del modelo restaurativo penal en México como paradigma emergente.
Is My Pancreas Showing? Insulin Pumps As An Extension To The Body. Wearable Tech And Identity And The Creation Of A Community
Authors: Peterson Paige 
Published: June 2023

<p> Insulin pumps and CGMs are medically necessary devices used by Type 1 Diabetics to help manage their illness. In order to function, these devices are continuously attached directly to the body. This major research project (MRP) examines how these devices influence and become integrated with the dress of nine participants with Type 1 Diabetes. Through data collected from ethnographic interviews along with an autoethnographic perspective, this research argues that Type 1 Diabetics perceive insulin pumps and CGMs as extensions of their body that result in the need to accommodate their dress as well as being items that they can adorn or decorate. This forms a phenomenological basis for Diabetic fashion. This MRP also explores how these devices make visible a previously invisible chronic illness and how this visibility signifies a shared phenomenological experience as the basis of a Diabetic community. </p>
Bill 21 ‘An Act Respecting the Laicity of the State:’ A critical discourse analysis problematizing the religious dress ban and its impacts on Québec’s social fabric
Authors: Rammal Rachel 
Published: June 2023

<p>[Para. 1 of Introduction]</p>
<p>On October 1st, 2018, Coalition Avenir Québec (CAQ) won the elections in Québec, Canada. The province’s centre-right to right-wing nationalist and autonomist political party led by businessman François Legault had prioritized as part of their electoral platform the secularization of Québécois institutions. On June 17, 2019, the CAQ fulfilled their electoral promise by adopting Bill 21 An Act respecting the Laicity of the State sponsored by Simon Jolin-Barrette, the Minister of Immigration, Francisation and Integration. The first secular legislation in Canada prohibits individuals in positions of public authority from wearing religious symbols while on duty. It affects all new public-sector hires including but not limited to, peace officers, judges, teachers, public servants, lawyers, and notaries. The decision to secularize Québec’s institutions is far from unanimous. Bill 21 has led to significant polarizations within the province and Canada. </p>
Watchdog Journalism In The Fifth Estate: The Diet Prada Effect
Authors: Forbes Phoebe 
Published: June 2023

<p>Diet Prada is a watchdog Instagram account in the fashion industry with over 1.8 million followers as of March 2020. This study explores how consumers interact with Diet Prada as a non-traditional media source and a watchdog journalist operating in the fifth estate. Using a mixed methods approach, this study interviewed 11 individuals to discuss their knowledge and experience with Diet Prada as an information source. A content analysis was conducted to analyze the 97 posts uploaded by the account between July to December of 2019. The study revealed that participants engaged with the Instagram account in a similar capacity to a traditional media source, citing convenience and accessibility. However, they were more likely to question the material they read on the Diet Prada account due to the lack of checks and balances. The study’s findings support the work surrounding the increasing tendency to use social media as an information source. </p>
Improving dental epithelial junction on dental implants with bioengineered peptides
Authors: Panayotov Ivan V. , Végh Attila G. , Martin Marta , Vladimirov Boyan , Larroque Christian , Gergely Csilla , Cuisinier Frédéric J. G. , Estephan Elias 
Published: June 2023

Introduction: The functionalization of titanium (Ti) and titanium alloys (Ti6Al4V) implant surfaces via material-specific peptides influence host/biomaterial interaction. The impact of using peptides as molecular linkers between cells and implant material to improve keratinocyte adhesion is reported.Results: The metal binding peptides (MBP-1, MBP-2) SVSVGMKPSPRP and WDPPTLKRPVSP were selected via phage display and combined with laminin-5 or E-cadherin epithelial cell specific peptides (CSP-1, CSP-2) to engineer four metal-cell specific peptides (MCSPs). Single-cell force spectroscopy and cell adhesion experiments were performed to select the most promising candidate. In vivo tests using the dental implant for rats showed that the selected bi functional peptide not only enabled stable cell adhesion on the trans-gingival part of the dental implant but also arrested the unwanted apical migration of epithelial cells.Conclusion: The results demonstrated the outstanding performance of the bioengineered peptide in improving epithelial adhesion to Ti based implants and pointed towards promising new opportunities for applications in clinical practice.
Patient preferences as human factors for health data recommender systems and shared decision making in orthopaedic practice
Authors: Singh Akanksha , Schooley Benjamin , Floyd Sarah B. , Pill Stephen G. , Brooks John M. 
Published: June 2023

BackgroundA core set of requirements for designing AI-based Health Recommender Systems (HRS) is a thorough understanding of human factors in a decision-making process. Patient preferences regarding treatment outcomes can be one important human factor. For orthopaedic medicine, limited communication may occur between a patient and a provider during the short duration of a clinical visit, limiting the opportunity for the patient to express treatment outcome preferences (TOP). This may occur despite patient preferences having a significant impact on achieving patient satisfaction, shared decision making and treatment success. Inclusion of patient preferences during patient intake and/or during the early phases of patient contact and information gathering can lead to better treatment recommendations.AimWe aim to explore patient treatment outcome preferences as significant human factors in treatment decision making in orthopedics. The goal of this research is to design, build, and test an app that collects baseline TOPs across orthopaedic outcomes and reports this information to providers during a clinical visit. This data may also be used to inform the design of HRSs for orthopaedic treatment decision making.MethodsWe created a mobile app to collect TOPs using a direct weighting (DW) technique. We used a mixed methods approach to pilot test the app with 23 first-time orthopaedic visit patients presenting with joint pain and/or function deficiency by presenting the app for utilization and conducting qualitative interviews and quantitative surveys post utilization.ResultsThe study validated five core TOP domains, with most users dividing their 100-point DW allocation across 1–3 domains. The tool received moderate to high usability scores. Thematic analysis of patient interviews provides insights into TOPs that are important to patients, how they can be communicated effectively, and incorporated into a clinical visit with meaningful patient-provider communication that leads to shared decision making.ConclusionPatient TOPs may be important human factors to consider in determining treatment options that may be helpful for automating patient treatment recommendations. We conclude that inclusion of patient TOPs to inform the design of HRSs results in creating more robust patient treatment profiles in the EHR thus enhancing opportunities for treatment recommendations and future AI applications.
Oviductal extracellular vesicles from women with endometriosis impair embryo development
Authors: Li Yuehan , Cai Lei , Guo Na , Liu Chang , Wang Meng , Zhu Lixia , Li Fei , Jin Lei , Sui Cong 
Published: June 2023

ObjectiveTo investigate the influence of oviductal extracellular vesicles from patients with endometriosis on early embryo development.DesignIn vitro experimental studySettingUniversity-affiliated hospital.PatientsWomen with and without endometriosis who underwent hysterectomy (n = 27 in total).InterventionsNone.Main outcome measuresOviductal extracellular vesicles from patients with endometriosis (oEV-EMT) or without endometriosis (oEV-ctrl) were isolated and co-cultured with two-cell murine embryos for 75 hours. Blastocyst rates were recorded. RNA sequencing was used to identify the differentially expressed genes in blastocysts cultured either with oEV-EMT or with oEV-ctrl. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed to identify potential biological processes in embryos that oEV-EMT affects. The functions of oEV on early embryo development were determined by reactive oxygen species (ROS) levels, mitochondrial membrane potentials (MMP), total cell numbers, and apoptotic cell proportions.ResultsExtracellular vesicles were successfully isolated from human Fallopian tubal fluid, and their characterizations were described. The blastocyst rates were significantly decreased in the oEV-EMT group. RNA sequencing revealed that oxidative phosphorylation was down-regulated in blastocysts cultured with oEV-EMT. Analysis of oxidative stress and apoptosis at the blastocysts stage showed that embryos cultured with oEV-EMT had increased ROS levels, decreased MMP, and increased apoptotic index. Total cell numbers were not influenced.ConclusionOviductal extracellular vesicles from patients with endometriosis negatively influence early embryo development by down-regulating oxidative phosphorylation.
Development and validation of a dynamic nomogram based on conventional ultrasound and contrast-enhanced ultrasound for stratifying the risk of central lymph node metastasis in papillary thyroid carcinoma preoperatively
Authors: Chen Qiyang , Liu Yujiang , Liu Jinping , Su Yuan , Qian Linxue , Hu Xiangdong 
Published: June 2023

PurposeThe aim of this study was to develop and validate a dynamic nomogram by combining conventional ultrasound (US) and contrast-enhanced US (CEUS) to preoperatively evaluate the probability of central lymph node metastases (CLNMs) for patients with papillary thyroid carcinoma (PTC).MethodsA total of 216 patients with PTC confirmed pathologically were included in this retrospective and prospective study, and they were divided into the training and validation cohorts, respectively. Each cohort was divided into the CLNM (+) and CLNM (−) groups. The least absolute shrinkage and selection operator (LASSO) regression method was applied to select the most useful predictive features for CLNM in the training cohort, and these features were incorporated into a multivariate logistic regression analysis to develop the nomogram. The nomogram’s discrimination, calibration, and clinical usefulness were assessed in the training and validation cohorts.ResultsIn the training and validation cohorts, the dynamic nomogram (https://clnmpredictionmodel.shinyapps.io/PTCCLNM/) had an area under the receiver operator characteristic curve (AUC) of 0.844 (95% CI, 0.755–0.905) and 0.827 (95% CI, 0.747–0.906), respectively. The Hosmer–Lemeshow test and calibration curve showed that the nomogram had good calibration (p = 0.385, p = 0.285). Decision curve analysis (DCA) showed that the nomogram has more predictive value of CLNM than US or CEUS features alone in a wide range of high-risk threshold. A Nomo-score of 0.428 as the cutoff value had a good performance to stratify high-risk and low-risk groups.ConclusionA dynamic nomogram combining US and CEUS features can be applied to risk stratification of CLNM in patients with PTC in clinical practice.
Sphingosylphosphorylcholine inhibits plasma cell differentiation and ameliorates experimental autoimmune encephalomyelitis
Authors: Park Byunghyun , Jeong Yu Sun , Hu Wonseok , Lee Mingyu , Kim Ji Cheol , Bae Geon Ho , Bae Yong-Soo , Bae Yoe-Sik 
Published: June 2023

IntroductionMultiple sclerosis (MS) is a potentially disabling disease that damages the brain and spinal cord, inducing paralysis of the body. While MS has been known as a T-cell mediated disease, recent attention has been drawn to the involvement of B cells in its pathogenesis. Autoantibodies from B cells are closely related with the damage lesion of central nervous system and worse prognosis. Therefore, regulating the activity of antibody secreting cell could be related with the severity of the MS symptoms.MethodsTotal mouse B cells were stimulated with LPS to induce their differentiation into plasma cells. The differentiation of plasma cells was subsequently analyzed using flow cytometry and quantitative PCR analysis. To establish an experimental autoimmune encephalomyelitis (EAE) mouse model, mice were immunized with MOG35–55/CFA emulsion.ResultsIn this study, we found that plasma cell differentiation was accompanied by upregulation of autotaxin, which converts sphingosylphosphorylcholine (SPC) to sphingosine 1-phosphate in response to LPS. We observed that SPC strongly blocked plasma cell differentiation from B cells and antibody production in vitro. SPC downregulated LPS-stimulated IRF4 and Blimp 1, which are required for the generation of plasma cells. SPC-induced inhibitory effects on plasma cell differentiation were specifically blocked by VPC23019 (S1PR1/3 antagonist) or TY52159 (S1PR3 antagonist), but not by W146 (S1PR1 antagonist) and JTE013 (S1PR2 antagonist), suggesting a crucial role of S1PR3 but not S1PR1/2 in the process. Administration of SPC against an EAE mouse model significantly attenuated the symptoms of disease, showing decreased demyelinated areas of the spinal cord and decreased numbers of cells infiltrated into the spinal cord. SPC markedly decreased plasma cell generation in the EAE model, and SPC-induced therapeutic effects against EAE were not observed in μMT mice.ConclusionCollectively, we demonstrate that SPC strongly inhibits plasma cell differentiation, which is mediated by S1PR3. SPC also elicits therapeutic outcomes against EAE, an experimental model of MS, suggesting SPC as a new material to control MS.
A novel stemness classification in acute myeloid leukemia by the stemness index and the identification of cancer stem cell-related biomarkers
Authors: Huang Yue , Zhang Zhuo , Sui Meijuan , Li Yang , Hu Yi , Zhang Haiyu , Zhang Fan 
Published: June 2023

BackgroundStem cells play an important role in acute myeloid leukemia (AML). However, their precise effect on AML tumorigenesis and progression remains unclear.MethodsThe present study aimed to characterize stem cell-related gene expression and identify stemness biomarker genes in AML. We calculated the stemness index (mRNAsi) based on transcription data using the one-class logistic regression (OCLR) algorithm for patients in the training set. According to the mRNAsi score, we performed consensus clustering and identified two stemness subgroups. Eight stemness-related genes were identified as stemness biomarkers through gene selection by three machine learning methods.ResultsWe found that patients in stemness subgroup I had a poor prognosis and benefited from nilotinib, MK-2206 and axitinib treatment. In addition, the mutation profiles of these two stemness subgroups were different, which suggested that patients in different subgroups had different biological processes. There was a strong significant negative correlation between mRNAsi and the immune score (r= -0.43, p&lt;0.001). Furthermore, we identified eight stemness-related genes that have potential to be biomarkers, including SLC43A2, CYBB, CFP, GRN, CST3, TIMP1, CFD and IGLL1. These genes, except IGLL1, had a negative correlation with mRNAsi. SLC43A2 is expected to be a potential stemness-related biomarker in AML.ConclusionOverall, we established a novel stemness classification using the mRNAsi score and eight stemness-related genes that may be biomarkers. Clinical decision-making should be guided by this new signature in prospective studies.
Risk of all-cause and cause-specific mortality associated with immune-mediated inflammatory diseases in Korea
Authors: Kwon Oh Chan , Lee See Young , Chun Jaeyoung , Han Kyungdo , Kim Yuna , Kim Ryul , Park Min-Chan , Kim Jie-Hyun , Youn Young Hoon , Park Hyojin 
Published: June 2023

ObjectiveImmune-mediated inflammatory disease (IMID) is associated with an increased risk of mortality. It is unclear whether the higher mortality is attributable to the IMIDs themselves or to the higher prevalence of comorbidities in IMIDs. We aimed to investigate whether IMIDs per se confer a higher risk of mortality.MethodsFrom the Korean National Health Insurance Service-National Sample Cohort database, this population-based cohort study included 25,736 patients newly diagnosed with IMIDs between January 2007 and December 2017, and 128,680 individuals without IMIDs who were matched for age, sex, income, hypertension, type 2 diabetes, dyslipidemia, and the Charlson comorbidity index. All individuals were retrospectively observed through December 31, 2019. The outcomes included all-cause and cause-specific mortalities. Adjustments for age, sex, and comorbidities were performed using multivariable Cox proportional hazard regression analyses, and adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) for the outcomes were estimated.ResultsThe adjusted risk of all-cause mortality was significantly lower in patients with IMIDs than that in those without (aHR, 0.890; 95% CI, 0.841–0.942). Regarding cause-specific mortality, cancer-specific (aHR, 0.788; 95% CI, 0.712–0.872) and cardiovascular disease-specific (aHR, 0.798; 95% CI, 0.701–0.908) mortalities were the two causes of death that showed significantly lower risks in patients with IMIDs. A similar trend was observed when organ based IMIDs were analyzed separately (i.e., gut, joint, and skin IMIDs).ConclusionAfter adjusting for comorbidities, IMIDs were associated with a lower risk of all-cause mortality compared to those without IMIDs. This was attributable to the lower risks of cancer-and cardiovascular disease-specific mortalities.
Preliminary study of anti-CD40 and ubiquitin proteasome antibodies in primary podocytopaties
Authors: Chebotareva Natalia , Cao Venzsin , Vinogradov Anatoliy , Alentov Igor , Sergeeva Natalia , Kononikhin Alexey , Moiseev Sergey 
Published: June 2023

BackgroundMinimal change disease and focal segmental glomerulosclerosis are primary podocytopathies that are clinically presented in adults presenting with severe nephrotic syndrome. The pathogenesis of these diseases is not clear and many questions remain to be answered. A new concept about the role of changes in the antigenic determinant of podocytes and the production of anti-podocyte antibodies that cause podocyte damage is being developed. The aim of the study is to evaluate the levels of anti-CD40 and anti-ubiquitin carboxyl-terminal hydrolase L1 (anti-UCH-L1) antibodies in patients with podocytopathies in comparison with other glomerulopathies.MethodsOne hundred and six patients with glomerulopathy and 11 healthy subjects took part in the study. A histological study revealed primary FSGS in 35 patients (genetic cases of FSGS and secondary FSGS in the absence of NS were excluded), 15 had MCD, 21 - MN, 13 - MPGN, 22 patients - IgA nephropathy. The effect of steroid therapy was evaluated in patients with podocytopathies (FSGS and MCD). The serum levels of anti-UCH-L1 and anti-CD40 antibodies were measured by ELISA before steroid treatment.ResultsThe levels of anti-UCH-L1 antibodies were significantly higher in MCD patients and anti-CD40 antibodies were higher in MCD and FSGS than in the control group and other groups of glomerulopathies. In addition, the level of anti-UCH-L1 antibodies was higher in patients with steroid-sensitive FSGS and MCD, and anti-CD40 antibodies were lower than in patients with steroid-resistant FSGS. An increase in anti-UCH-L1 antibody levels above 6.44 ng/mL may be a prognostic factor of steroid-sensitivity. The ROC curve (AUC = 0.875 [95% CI 0.718–0.999]) for response to therapy showed a sensitivity of 75% and specificity of 87.5%.ConclusionAn increase in the level of anti-UCH-L1 antibodies is specific for steroid-sensitive FSGS and MCD, while an increase in anti-CD40 antibodies – for steroid-resistant FSGS, compared with other glomerulopathies. It suggests that these antibodies could be a potential factor for differential diagnosis and treatment prognosis.
Serial deep gray nuclear DTI changes in Parkinson’s disease over twelve years
Authors: Shih Yao-Chia , Ooi Leon Qi Rong , Li Hui-Hua , Allen John Carson , Hartono Septian , Welton Thomas , Tan Eng-King , Chan Ling Ling 
Published: June 2023

BackgroundDeep gray nuclear pathology relates to motor deterioration in idiopathic Parkinson’s disease (PD). Inconsistent deep nuclear diffusion tensor imaging (DTI) findings in cross-sectional or short-term longitudinal studies have been reported. Long-term studies in PD are clinically challenging; decade-long deep nuclear DTI data are nonexistent. We investigated serial DTI changes and clinical utility in a case-control PD cohort of 149 subjects (72 patients/77 controls) over 12 years.MethodsParticipating subjects underwent brain MRI at 1.5T; DTI metrics from segmented masks of caudate, putamen, globus pallidus and thalamus were extracted from three timepoints with 6-year gaps. Patients underwent clinical assessment, including Unified Parkinson Disease Rating Scale Part 3 (UPDRS-III) and Hoehn and Yahr (H&amp;Y) staging. A multivariate linear mixed-effects regression model with adjustments for age and gender was used to assess between-group differences in DTI metrics at each timepoint. Partial Pearson correlation analysis was used to correlate clinical motor scores with DTI metrics over time.ResultsMD progressively increased over time and was higher in the putamen (p &lt; 0.001) and globus pallidus (p = 0.002). FA increased (p &lt; 0.05) in the thalamus at year six, and decreased in the putamen and globus pallidus at year 12. Putaminal (p = 0.0210), pallidal (p = 0.0066) and caudate MD (p &lt; 0.0001) correlated with disease duration. Caudate MD (p &lt; 0.05) also correlated with UPDRS-III and H&amp;Y scores.ConclusionPallido-putaminal MD showed differential neurodegeneration in PD over 12 years on longitudinal DTI; putaminal and thalamic FA changes were complex. Caudate MD could serve as a surrogate marker to track late PD progression.