bluuebunny/crossref_metadata_2025_split huggingface dataset:
Animasi media pembelajaran keislaman untuk anak autis dan tuna wicara di Rumah Qur’an Inklusif Sidoarjo
Authors: Anita Puji Astutik  , Safitri Khoirinindyah  , Muhammad Ridho Adzani  
Published: February 2023

This community service activity was carried out at the Ananda Mutiara Indonesia Foundation (Y-AMI), which assists Children with Special Needs (ABK) in the Sidoarjo area. One problem that arises is the need to meet limited learning tools and learning media that must be creative and creative, making the teaching of the Qur'an and Islam problematic. Problems related to the learning media cannot be adjusted to the classification of autism and speech-impaired children's disorders. Learning the Qur'an and Islam that is not by the needs of children with autism and speech impairment is a problem in this community. Through Participatory Action Research (PAR), the servants determine solutions to partner problems, including teaching methods for reading the Qur'an that is tailored to the individual conditions of children with autism, namely the Qur'an learning media by the WAFA method, which means the teaching method uses the right brain) which is designed creatively and innovatively by applying the Kinemaster learning video animation community service product. Meanwhile, Islamic learning methods are also adapted to the individual conditions of speech-impaired children, namely by using Islamic learning media that are designed creatively and innovatively by applying the community service product, animation video, and Kinemaster learning.
(Kegiatan pengabdian masyarakat ini dilaksanakan di Yayasan Ananda Mutiara Indonesia (Y-AMI) yang bergerak pada pendampingan Anak Berkebutuhan Khusus (ABK) daerah Sidoarjo. Salah satu problematika yang timbul yakni kebutuhan dalam pemenuhan perangkat pembelajaran yang terbatas serta media pembelajaran yang harus berinovasi dan kreatif menjadikan problematika pengajaran Al-Qur’an dan Keislaman. Keresahan media pembelajaran yang belum bisa disesuaikan dengan klasifikasi gangguan anak autism dan tuna wicara. Pembelajaran Al-Qur’an dan Keislaman yang belum sesuai dengan kebutuhan anak autism dan tuna wicara menjadi permasalahan dalam komunitas ini. Melalui pendekatan Partisipatoris, pengabdi menentukan solusi dari permasalahan mitra, antara lain metode pengajaran membaca Al-Qur’an disesuaikan dengan kondisi individu anak autism yaitu dengan menggunakan media pembelajaran Al-Qur’an metode WAFA (metode yang pengajarannya menggunakan otak kanan) yang didesain kreatif dan inovatif dengan menerapkan produk pengabdian masyarakat animasi video pembelajaran Kinemaster. Sedangkan metode pembelajaran keislaman juga disesuaikan dengan kondisi individu anak tuna wicara yaitu dengan menggunakan media pembelajaran keislaman yang didesain kreatif dan inovatif dengan menerapkan produk pengabdian masyarakat animasi video pembelajaran Kinemaster).
MENJAMU: pelatihan branding dan packaging produk unggulan desa Karangwungu sebagai penguat ekonomi masyarakat
Authors: Ulfah Anisa , Yusniah Selma , Muthoharoh Alfi Nur Lailatul , Akbar Muhammad , Rozaq Muhammad 
Published: February 2023

Karangwungu Village, Karanggeneng District, Lamongan Regency, is one of the villages with great potential in developing Small and Medium Enterprises (Usaha Mikro Kecil Menengah). 18 household heads run a cottage industry by producing herbal medicine as well as tempeh and tofu as the village's main products. The cottage industry is quite promising as a support for the community's economy, but it is still carried out traditionally. This is because they do not know how to use information technology. For this reason, through the Kuliah Kerja Nyata (KKN) in 2021, training was carried out to increase their insight so that they can market and package products more attractively. This needs to be done so that the products can reach a wider range of consumers. The methods used are observation, training, and reflection. The training resulted in the branding name 'Menjamu' as a brand of herbal medicine, and the packaging design was made. The results of the reflection showed that the community felt enthusiastic and was greatly helped by the training because it could increase their insight regarding product branding and packaging. This is expected to increase the results of product marketing that can strengthen the community's economy.(Desa Karangwungu, Kecamatan Karanggeneng, Kabupaten Lamongan, merupakan salah satu desa yang memiliki potensi besar dalam pengembangan UMKM (Usaha Mikro Kecil Menengah). Terdapat 18 kepala keluarga yang menjalankan industri rumahan dengan memproduksi jamu herbal serta tempe dan tahu sebagai produk unggulan desa. Industri rumahan tersebut cukup menjanjikan sebagai penopang ekonomi masyarat, tetapi masih dijalankan dengan cara tradisional. Hal tersebut disebabkan pelakunya belum memiliki pemahaman terkait teknologi informasi. Untuk itu, melalui kegiatan Kuliah Kerja Nyata (KKN) pada 2021, dilakukan pelatihan yang bertujuan untuk meningkatkan wawasan mereka agar dapat mem-branding dan mengemas produk dengan lebih menarik. Hal tersebut perlu dilakukan agar produk yang dihasilkan dapat menjangkau konsumen yang lebih luas. Metode yang digunakan ialah observasi, pelatihan, dan refleksi. Pelatihan menghasilkan nama branding ‘menjamu’ sebagai merek jamu herbal sekaligus pembuatan desain kemasannya. Hasil refleksi menunjukkan bahwa masyarakat merasa antusias dan sangat terbantu dengan diadakannya pelatihan karena dapat meningkatkan wawasan mereka terkait branding dan packaging produk. Hal tersebut diharapkan dapat meningkatkan hasil pemasaran produk yang dapat menguatkan ekonomi masyarakat).
Effects of combination of alcohol and Cinnamomum burmannii essential oil against Klebsiella pneumoniae resistance
Authors: Sasangka Jennifer Anggraini , Suyono Handi , Waworuntu Gladdy Lysias 
Published: February 2023

Alcohol-based antiseptics are widely used in the COVID-19 pandemic to prevent the transmission of infections, including bacterial infections. However, bacterial resistance to the alcohol-based antiseptics is begun reported. Klebsiella pneumonia resistance is one of the bacterial resistances that is prioritized by the WHO to be overcome. Cinnamomum burmannii essential oil, containing cinnamaldehyde and eugenol, was investigated for antimicrobial activity. This study aimed to evaluate the synergistic effect of the combination of alcohol and C. burmannii essential oil in inhibiting bacterial growth. Ethanol 80% in a combination with C. burmannii essential oil at concentrations of 1, 2, and 3% v/v were evaluated against K. pneumoniae using the Kirby-Bauer disc diffusion method. Test was repeated three times in independent experimental. Inhibition zone diameter (IZD, mm) and antimicrobial index (AI, %) were determined and analyzed using Kruskal-Wallis test continued the Mann-Whitney test. The combination of ethanol and C. burmannii essential oil was sensitive to K. pneumoniae, meanwhile, ethanol 80% was not more sensitive. The IZD of the combination solution at 1, 2, and 3% concentration were 6.7±0.19, 9.0±0.58, and 11.0±1.15mm, respectively (p<0.05). The AI of the combination solution at concentrations of 1, 2, and 3% v/v were 7.04±2.04, 30.53±6.79, and 51.64±12.91%, respectively (p<0.05). In conclusion, the combination of ethanol 80% and C. burmannii essential oil active against K. pneumoniae which resistant to the ethanol.
Facial nerve paralysis in nasopharyngeal carcinoma: a case report
Authors: Kristiyanto Jarod Wahyu , Muyassaroh Muyassaroh , Antono Dwi 
Published: February 2023

Nasopharyngeal carcinoma (NPC) is cancer originating from the mucosal lining of nasopharynx, with the highest predilection in the fossa of Rosenmüller. One-fifth of NPC cases have cranial nerve complications. The location of Rosenmüller's fossa which is adjacent to foramen lacerum and middle base of the cranium allows the tumor to extend directly into the cranium and surrounding cranial nerves. This paper reported a case of facial nerve paralysis in NPC. A 55-year-old man came to the Ear-Nose-Throat (ENT) Clinic at Dr. Kariadi General Hospital, Semarang with complaints of facial pain on the right side, headache, a lump on the left neck, fullness in ears, and nosebleed. However, the patient did not complain of double vision. After a thorough history taking, physical examination, radiology, and histopathology tests, the patient was diagnosed with WHO 3 ECOG I T3N2M0 stage III NPC with House Brackmann III facial nerve paresis at the level of Mastoid segment. The patient was treated using chemotherapy treatment by an ENT specialist with a chemotherapy regimen of paclitaxel-cisplatin for 6 cycles. In conclusion, although rare, NPC can cause facial nerve paralysis.
Coinfection of COVID-19 and dengue: a case report
Authors: Indrarto Fx. Wikan 
Published: February 2023

Dengue hemorrhagic fever (DHF) and corona virus disease 2019 (COVID-19) are two viral infectious diseases that can occur simultaneously and have the potential to complicate each other. Therefore, sustained attention to this phenomenon is required. A 9 y.o. boy was diagnosed with dengue and COVID-19 at the Panti Rapih Hospital in Yogyakarta, Indonesia, in the early phase of the COVID-19 pandemic. Both viral infectious diseases have distinctive clinical and laboratory features. Acute fever, vomiting, weakness, thrombocytopenia, and hemoconcentration that improve from day 5 after infection are typical symptoms of DHF in children. Complaints of fever, runny nose, cough, and pain when swallowing that usually occurs in COVID-19 also appeared. Medical investigations with serological tests for DHF and COVID-19 at the beginning of the COVID-19 pandemic can be used to diagnose these two infections because standard diagnostic tools using the PCR swab test cannot yet be performed. Symptomatic therapy for moderate degrees of these two viral infections is appropriate.
The effect of prophylactic negative pressure wound therapy on infection in obese women after C-section: a meta-analysis
Authors: Widiyanto Aris , Putri Santy Irene , Fajriah Asruria Sani , Peristiowati Yuly , Ellina Agusta Dian , Triatmojo Joko 
Published: February 2023

Most caesarean wounds resulted in infection. This become a huge burden on the health care system, considering the high number of women undergoing this type of surgery. Negative pressure wound therapy (NPWT) has been recommended for a wide variety of lesions including open abdominal wounds. The purpose of this study was to investigate the effect of prophylactic NPWT on infection in obese women after a C-section. This was a systematic review and meta-analysis study that used articles from online databases of EBSCO, Google Scholar, and PubMed which published until 2022. The dependent variable was infections post C-section, while the independent were NPWT and standard wound therapy. The data was analyzed by RevMan 5.3. This study showed that there is no difference in the outcome of superficial site infection (SSI), deep site infection (DSI), wound dehiscence, seroma, and hematoma between women with obesity after caesarean delivery who used NPWT and standard dressing.
Preoperative Muscle Biopsy to Assess Motor End Plate Integrity as a Predictor for Successful Nerve Transfer
Authors: Chen Vivian Y. , Gonzales Luigi P. , Johnston Tyler R. , Steward Oswald , Gupta Ranjan 
Published: February 2023

Case:
A 60-year-old right-hand–dominant man was referred for persistent right deltoid weakness, lateral shoulder numbness, and severe functional deficit 3 months after undergoing proximal humerus open reduction and internal fixation with plate and fibular strut allograft. Deltoid muscle biopsy demonstrated motor end plate (MEP) degeneration. After partial radial-to-axillary nerve transfer, repeat deltoid muscle biopsy revealed successful regeneration of MEPs with reinnervation of deltoid confirmed with postnerve transfer electromyography.

Conclusion:
Selective nerve transfer can successfully rescue a denervated target muscle from further degeneration by restoration of healthy MEPs.
Bilateral Chronic Quadriceps Tendon Ruptures Treated with Hamstring Autograft Reconstruction
Authors: Feldman Matthew W. , Wade Sean M. , McCarthy Conor F. , Kinnard Matthew J. , Avery Anthony L. 
Published: February 2023

Case:
A 30-year-old semiprofessional football player presented with chronic bilateral quadriceps tendon ruptures. Both quadriceps tendon ruptures were unsuitable for isolated primary repair because of tendon retraction and immobility. A novel reconstruction technique using semitendinosus and gracilis tendon autografts was performed to restore both lower extremities’ disrupted extensor mechanisms. At the final follow-up, the patient regained excellent motion of both knees and returned to high-intensity activity.

Conclusion:
Chronic quadriceps tendon ruptures present challenges related to tendon quality and mobilization. Reconstruction with hamstring autograft using a Pulvertaft weave through the retracted quadriceps tendon in a high-demand athletic patient represents a novel approach for treating this injury.
Network Pharmacology Approach to LHQW Indicates Naringenin Targets Several Core Proteins to Regulate Multiple Biological Pathways to Treat and Prevent PRRSV-associated Pneumonia
Authors: Huang Cai-Yun , Liu Lin , He Yan-Xia , Zhang Yang , Guo Xiao-Yin , Wu Bao-Qing 
Published: February 2023

Abstract
Background
Porcine respiratory and reproductive syndrome(PRRS) is still the most undermine viral disease in hog(Sus scrofa domestica,Sus) farming without effective drug of treatment. This study is aimed to discover its molecular mechanism and provide potential drug targets of LHQW(Lanhua Qingwen) against PRRS.
Methods
An LHQW target gene set was established from Traditional Chinese Medicine Systems Pharmacology database(TCMSP) and Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine (TCMIP),PRRSV(Porcine respiratory and reproductive syndrome virus)-associated pneumonia–related gene set was obtained from 5 disease-gene databases.,Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and Protein-protein interaction (PPI) network were performed to discover the potential proteins.Molecular docking was performed to identify the patterns of interactions between the effective molecules and targeted proteins.
Results
A total of 509 bioactive ingredients and 255 targets of LHQW as well as 2738 PRRSV-associated pneumonia genes were obtained.The GO and KEGG indicated that LHQW can act by regulating stress response,virus infection and immune response.PPI networks and subnetworks identified 9 core genes.The molecular docking was conducted on the most significant gene MAP kinase-activated protein kinase 3(MAPK3) and other genes of RAC-alpha serine/threonine-protein kinase(AKT1),estrogen receptor 1(ESR1),MAP kinase-activated protein kinase 1(MAPK1),transcription factor p65(RELA) and Heat shock protein HSP 90-alpha(HSP90AA1),which are involved in virus infection,inflammation and oxidative stress pathways.Naringenin can target simultaneously the active pockets of these 6 proteins which exerting potential therapeutic effects in PRRS.
Conclusions
The network pharmacological strategy integrates molecular docking to unravel the molecular mechanism of LHQW.Naringenin is a promising molecule for target of MAPK3,AKT1,ESR1,MAPK1,RELA and HSP90AA1 involving in oxidative stress,metabolic regulation,anti-inflammatory and immune defence pathways to treat PRRSV-associated pneumonia.
Factors associated with increased risk of playing-related disorders among music students. Results of the Risk of Music Students (RISMUS) longitudinal study
Authors: Cruder Cinzia , Soldini Emiliano , Gleeson Nigel , Barbero Marco 
Published: February 2023

Abstract
Playing-related musculoskeletal disorders (PRMDs) are common among musicians but longitudinal data on risk factors are limited. The aim of the study was to longitudinally identify the factors associated with increased risk of PRMD onset among music students enrolled in different pan-European music institutions.
Eight hundred and fifty students from 56 European music universities completed a web-based questionnaire on lifestyle and physical activity participation levels, musical practice habits, behaviours toward prevention, health history and PRMDs, as well as psychological distress, perfectionism and fatigue. PRMD onset was assessed prospectively at 6 and 12 months.
Changes in physical activity level (6-month AOR=2.343, 12-month-AOR=2.346; AOR>1), increased levels of fatigue (6-month AOR=1.084, 12-month-AOR=1.081; AOR>1) and of socially-prescribed perfectionism (6-month AOR=1.102; AOR>1) were significantly associated with PRMD onset. The presence of MSK complaints at baseline (6-month AOR=0.145, 12-month-AOR=0.441; AOR<1) and changes to BMI (12-month AOR=0.663; AOR<1) limited the onset of PRMDs. The incidence of PRMD at 6 and 12 months were 28.8% and 49.0%, respectively.
Longitudinal findings have been appraised as potential factors for PRMD onset, addressing the lack of any similar type of data in the current literature, while offering a novel contextualisation for revisiting contemporary evidence-based preventive strategies to minimise the impact of PRMDs.
Innovative-oriented start-ups across countries: Conditions for the positive effect of a financial system
Authors: Reddy Colin David 
Published: February 2023

Abstract

This study sets out to examine the effect of financial systems on the share of a nation's start-ups that are innovative-oriented. The study combines the national business systems perspective with the resource-based view to argue that the financial system substitutes for a weak state and skill development system. This argument is supported by an analysis of a panel data set comprising 283 country-year data over five years. The study shows that it is necessary to model innovative entrepreneurship differently than other aspirational entrepreneurship forms. Because innovations develop out of the efforts of multiple actors, it becomes necessary to model an interaction between system components.
Stories of a water-table: anomalous depressions, aquitard breaches and seasonal implications, Shelby County, Tennessee, USA.
Authors: Lozano-Medina Daniela , Waldron Brian , Schoefernacker Scott , Antipova Anzhelika , Villalpando-Vizcaino Rodrigo 
Published: February 2023

Abstract
An extensive water level survey of the water-table aquifer (i.e., shallow aquifer) within Shelby County, Tennessee, was conducted in the dry (Fall 2020) and wet (Spring 2021) seasons. Water-table surfaces were generated using cokriging to observe seasonal differences to identify anomalous water-table depressions, indicative of an underlying aquitard breach. Seasonal differences were attributed to non-coincident control and timing between the surveys as well as when optimum dry (fall) and wet (spring) conditions existed, as observed through comparisons with continuous historical water levels from 12 shallow monitoring wells. Additionally, data from Fall 2020 were compared to previous studies in 2005 and 2015 to determine decadal changes in levels and shape of the water-table surface which were mostly attributed to changes in data control and potential climate variations. A prediction error map was generated from the 2020 dataset to identify areas of the county with high-prediction error (> 7.0 m) to offer guidance on where future well control would be optimal.
Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons
Authors: Boyd Rachel J. , McClymont Sarah A. , Barrientos Nelson B. , Hook Paul W. , Law William D. , Rose Rebecca J. , Waite Eric L. , Rathinavelu Jay , Avramopoulos Dimitrios , McCallion Andrew S. 
Published: February 2023

Abstract
To overcome the ethical and technical limitations of in vivo human disease models, the broader scientific community frequently employs model organism-derived cell lines to investigate of disease mechanisms, pathways, and therapeutic strategies. Despite the widespread use of certain in vitro models, many still lack contemporary genomic analysis supporting their use as a proxy for the affected human cells and tissues. Consequently, it is imperative to determine how accurately and effectively any proposed biological surrogate may reflect the biological processes it is assumed to model. One such cellular surrogate of human disease is the established mouse neural precursor cell line, SN4741, which has been used to elucidate mechanisms of neurotoxicity in Parkinson disease for over 25 years. Here, we are using a combination of classic and contemporary genomic techniques – karyotyping, RT-qPCR, single cell RNA-seq, bulk RNA-seq, and ATAC-seq – to characterize the transcriptional landscape, chromatin landscape, and genomic architecture of this cell line, and evaluate its suitability as a proxy for midbrain dopaminergic neurons in the study of Parkinson disease. We find that SN4741 cells possess an unstable triploidy and consistently exhibits low expression of dopaminergic neuron markers across assays, even when the cell line is shifted to the non-permissive temperature that drives differentiation. The transcriptional signatures of SN4741 cells suggest that they are maintained in an undifferentiated state at the permissive temperature and differentiate into immature neurons at the non-permissive temperature; however, they may not be dopaminergic neuron precursors, as previously suggested. Additionally, the chromatin landscapes of SN4741 cells, in both the differentiated and undifferentiated states, are not concordant with the open chromatin profiles of ex vivo, mouse E15.5 forebrain- or midbrain-derived dopaminergic neurons. Overall, our data suggest that SN4741 cells may reflect early aspects of neuronal differentiation but are likely not a suitable a proxy for dopaminergic neurons as previously thought. The implications of this study extend broadly, illuminating the need for robust biological and genomic rationale underpinning the use of in vitro models of molecular processes.
Efficacy and safety of duloxetine in chronic musculoskeletal pain: A systematic review and meta-analysis
Authors: Ma Xuezhi , Zhou Shijie , Sun Wenyuan , Sun Jie , Li Guangguang , Wang Lining , Guo Yang 
Published: February 2023

Abstract
Background
Chronic musculoskeletal pain (CMP) is a complex pain condition, and the treatment of CMP is mainly based on analgesic drugs now. Psychotherapy is a non-negligible factor in the treatment of CMP. Duloxetine, as a means of psychological intervention, is an effective treatment option for CMP patients. This article aims to evaluate the efficacy and safety of duloxetine in the treatment of CMP.
Databases and Data Treatment:
We searched PubMed, Web of Science, Embase, Cochrane Library from inception to May, 2022. Randomized controlled trials (RCTs) evaluating the efficacy and safety of duloxetine versus placebo in CMP patients were included. We identified 13 articles and studied a population of 4201 participants in 4 countries.
Results
This meta-analysis showed that the duloxetine has statistically significant compared with the placebo control, benefits on 24-hour average pain, living quality, physical function, and global impressions and there was no difference in the incidence of serious adverse event. In general, psychotherapy can improve mood and pain level at the same time.
Conclusions
This review shows a significant contribution of duloxetine to CMP symptom relief. This meta-analysis improved that duloxetine can significantly reduce the pain level of patients, improve depressive symptoms and global impression, and has no obvious serious adverse reactions. However, additional studies are required to confirm the relationship between psychological diseases and chronic pain and explore their internal links.