bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenging lesions in cervical cytology: The elusive HSIL
Authors: Torous Vanda F. 
Published: September 2023

AbstractCervical cytology has been an integral part of cervical cancer screening since the mid‐20th century with the implementation of screening protocols utilising Pap testing. During that time, cervical cancer has gone from the leading cause of cancer deaths in women to not even appearing in the top 10 causes of US cancer deaths. However, despite its long and widespread use, cervical cytology remains a diagnostically challenging area in the practice of cytopathology. Of particular importance for diagnosticians is the accurate diagnosis of high‐grade squamous intraepithelial lesions (HSILs), given the significant risk of progression to invasive cervical cancer and the importance to patient management. Therefore, this review is presented in order to highlight the diagnostic features of HSIL, its various appearances, and important benign and neoplastic differential considerations with an emphasis on morphological clues that can aid in distinguishing between these different processes.
Rates of John Cunningham virus seroconversion greatly reduced in natalizumab‐treated patients during COVID‐19‐related lockdowns
Authors: Dwyer Chris , Sharmin Sifat , Kalincik Tomas 
Published: September 2023

AbstractBackground and purposeThis study was undertaken to retrospectively compare rates of John Cunningham virus (JCV) seroconversion in natalizumab‐treated patients before and during COVID‐19‐related community restrictions. Natalizumab is highly effective therapy for relapsing–remitting multiple sclerosis. Prolonged exposure to natalizumab in JCV‐positive patients can cause progressive multifocal leukoencephalopathy, a potentially fatal brain infection. Serial assessment of JCV status is required for patients receiving natalizumab.MethodsPatients receiving natalizumab at the Royal Melbourne Hospital were assessed for change in JCV serostatus and duration of exposure to natalizumab in two discrete time periods: from 1 February 2012 until 1 February 2017 (“pre‐COVID”; n = 128) and from 1 April 2020 until 12 October 2022 (“COVID”; n = 214). A Poisson regression model adjusted for age at natalizumab commencement and sex was used to model seroconversion rate between the two time periods.ResultsThe pre‐COVID JCV seroconversion rate among natalizumab‐treated patients at the Royal Melbourne Hospital was 9.08%. Conversely, we found a precipitous decline in JCV seroconversion during COVID lockdown. Annualized seroconversion during COVID‐19‐related restrictions was 2.01%. The annualized seroconversion rate was 4.7 times higher during the pre‐COVID‐19 period (95% confidence interval = 2.96–7.45, p < 0.0001) compared to the annualized seroconversion rate during COVID lockdown. Males had a 2× higher rate of seroconversion compared to females.ConclusionsJCV seroconversion among natalizumab‐treated patients was markedly lower during COVID‐19‐related community restrictions. Restrictions observed in Melbourne were among the longest and most comprehensive implemented worldwide. This suggests the presence of modifiable risk factors that could lower rates of JCV seroconversion among natalizumab‐treated patients.
The utility of trauma evaluations in judicial decision‐making in child sex trafficking cases: A qualitative analysis
Authors: Sprang Ginny , Ascienzo Sarah , Atwater Chelsea , Cole Jennifer 
Published: September 2023

AbstractYouth coerced into trafficking experience multiple forms of abuse, and are deprived of basic human rights associated with liberty and self‐determination, all of which can adversely affect mental and psychological well‐being (Ottisova et al., Behavioral Medicine, 44(3), 234‐241.). This study uses a qualitative approach to exploring how judges use trauma‐related information to make decisions about how to adjudicate cases involving minors who have been sexually trafficked. Additionally, the study identifies barriers to receiving data, the court resources needed to effectively respond, and potential remedies to address gaps in effective case management. The study uses data from 82 juvenile and family court judges from around the USA 27‐item structured interview was used to determine the availability and utility of trauma services, needed resources, and solutions to overcome gaps in effective case adjudication. Themes emerged related to lack of access to and timing issues that limited the utility of reports, lack of congruency between recommendations and available resources and child and family resistance to disclosures. Solutions to overcome barriers are related to increased cross‐disciplinary collaboration, awareness and responsiveness. Legal remedies such as Safe Harbor laws can only be realized if the systemic context is aligned and appropriately resourced toward responsiveness.
Interprofessional clinical decision‐making process in health: A scoping review
Authors: Bouchez Tiphanie , Cagnon Clémence , Hamouche Gouraya , Majdoub Marouan , Charlet Jean , Schuers Matthieu 
Published: September 2023

AbstractAimsTo describe the key elements of the interprofessional decision‐making process in health, based on published scientific studies. To describe the authors, reviews and subject matter of those publications.DesignScoping review of the literature.Data SourcesMEDLINE, APA Psycinfo OpenGrey, Lissa and Cochrane databases were searched in December 2019 and January 2023.Review MethodsReferences were considered eligible if they (i) were written in French or English, (ii) concerned health, (iii) studied a clinical decision‐making process, (iv) were performed in an interprofessional context. ‘PRISMA‐scoping review’ guidelines were respected. The eligible studies were analysed and classified by an inductive approachResultsWe identified 1429 sources of information, 145 of which were retained for the analysis. Based on these studies, we identified five key elements of interprofessional decision‐making in health. The process was found to be influenced by group dynamics, the available information and consideration of the unique characteristics of the patient. An organizational framework and specific training favoured improvements in the process.ConclusionDecision‐making can be based on a willingness of the healthcare organization to promote models based on more shared leadership and to work on professional roles and values. It also requires healthcare professionals trained in the entire continuum of collaborative practices, to meet the unique needs of each patient. Finally, it appears essential to favour the sharing of multiple sources of accessible and structured information. Tools for knowledge formalization should help to optimize interprofessional decision‐making in health.ImpactThe quality of a team decision‐making is critical to the quality of care. Interprofessional decision‐making can be structured and improved through different levels of action. These improvements could benefit to patients and healthcare professionals in every settings of care involving care collaboration.Impact StatementInterprofessional decision‐making in health is an essential lever of quality of care, especially for the most complex patients which are a contemporary challenge. This scoping review article offers a synthesis of a large corpus of data published to date about the interprofessional clinical decision‐making process in healthcare. It has the potential to provide a global vision, practical data and a list of references to facilitate the work of healthcare teams, organizations and teachers ready to initiate a change.
Biogeography and depth partitioning in deep‐sea gastropods at the Pacific Costa Rica Margin
Authors: Betters Melissa , Stabbins April , Keller Abigail , Cordes Erik 
Published: September 2023

AbstractAimUnderstanding the global distribution of biodiversity and the factors that influence it are among the central goals of biogeography. How abiotic and biotic factors limit species' ranges has been investigated across a variety of environments and taxonomic groups. However, such investigations across oceanic depths remain underrepresented, particularly for chemosynthetic environments such as hydrocarbon seeps. The depth differentiation (DD) hypothesis suggests that steep environmental gradients in the upper depths of the ocean may limit species' ranges over relatively short vertical distances. The present study aims to investigate the evidence for the DD hypothesis at hydrocarbon seep sites along the Pacific Costa Rica Margin (CRM) by investigating the biogeographic distributions of gastropods sampled there and the factors that influence them.LocationCosta Rica.TaxonMollusca, Gastropoda, Provannidae, Genus: Provanna (Dall, 1918).Methods1813 Provanna snails were collected across 1300 metres (m) of depth from Costa Rican hydrocarbon seeps. To test the DD hypothesis, species partitioning across the depth range was investigated. In addition to gradients in oceanographic conditions, such as temperature, oxygen, and salinity, other factors potentially responsible for filtering species were also considered as alternative hypotheses, including the availability of biogenic substrate, the availability of and reliance on chemosynthetic fluids, and specific preferences for certain environmental conditions.Results and Main ConclusionsThree species of Provanna were identified from the CRM and exhibited partitioning across depth. For the two dominant species (P. laevis and P. goniata), the data suggest that depth‐associated oceanographic conditions are more likely than any other factor investigated to explain their observed partitioning across depth, supporting the DD hypothesis. This study also presents novel evidence that such partitioning may be unilaterally determined, wherein species with narrower depth ranges may limit the local depth ranges of others. This study represents an extension of biogeographic range limit literature into chemosynthetic habitats and across oceanic depths.
Nesting activity of Lepidochelys olivacea, and the effect of artificial shade at Cascajilloso beach, a newly inhabited nesting site in Pacific Panama
Authors: Flores Eric E. , De La Cruz Joelbin Rafael 
Published: September 2023

AbstractSea turtle nesting activity on newly monitored beaches yield important data to support future regional and global conservation assessments. Here, we report on nesting activity of Olive Ridley (Lepidochelys olivacea) at Cascajilloso beach in Pacific Panama based on data from a new hatchery during seasons 2019, 2020 and 2021. Further to this, we conducted a field experiment analyzing the effects of artificial shade versus unshaded treatments on hatchlings' biometric characteristics, hatching success, incubation success and the incubation period. The analyses of three seasons showed that nesting activity, based on number of egg clutches transferred to the hatchery, reached a peak between September (33%) and October (25%). Curved carapace length (CCL) of nesting females (64.3–66.2 cm) was similar to other populations of the Eastern Tropical Pacific (ETP). The number of eggs clutches were 80 in 2019, 73 in 2020 and 108 in 2021; however, the clutch size was slightly smaller (93.92 ± 18.78 eggs) compared with other populations of the ETP. This could be a phenotypic variation of nesting females at this beach. The ability to move egg clutches to the hatchery was affected during 2020 season due to COVID19 restrictions. Heavy rainfall during the incubation period caused a reduction in ambient temperature resulting in cooler (maximum average 29.9°C) nest temperatures registered under artificial shade and unshaded treatments. This could result in males hatchlings during the 2020 season. The warmer temperatures in our experimental nests produced heavier hatchlings contrary to general assumptions, but this was also related to straight carapace length only after a threshold value of 40 mm. Hatchlings under the artificial shade were able to grow to a certain size but potentially at the costs of storing less mass (trade‐off). Ongoing beach patrolling and hatchery management techniques with long‐term baseline data collection are needed to secure the nesting population of L. olivacea in this recently surveyed beach.
Phosphorylation of MAP 1A regulates hyperphosphorylation of Tau in Alzheimer's disease model
Authors: Cai Biao , Shao Nan , Ye Ting , Zhou Peng , Si Wenwen , Song Hang , Wang Guangyun , Kou Junping 
Published: September 2023

AbstractBackground and purposeHyperphosphorylation of Tau is one of the important pathological features of Alzheimer's disease (AD). Therefore, studying the mechanisms behind Tau hyperphosphorylation is crucial in exploring the pathogenesis of neurological damage in AD.MethodsIn this study, after the establishment of rat models of AD, quantitative phosphoproteomics and proteomics were performed to identify proteins, showing that phosphorylation of microtubule associated protein 1A (MAP 1A) was lower in the model group. Western blot confirmed the changes of MAP 1A in the SD rats, APP/PS1 transgenic mice and cell AD models. To further study the molecular mechanism of recombinant MAP 1A phosphorylation affecting Tau phosphorylation, interfering siRNA‐MAP 1A and protein immunoprecipitation reaction analysis were performed in AD cell models.ResultsCyclin‐dependent kinase 5 (CDK5) showed reduced binding to MAP 1A and increased binding to Tau, resulting in a decrease in phosphorylated MAP 1A (p‐MAP 1A) and an increase in phosphorylated Tau (p‐Tau), and MAP 1A silencing promoted binding of CDK5‐Tau and increased Tau phosphorylation, thereby reducing the cell survival rate.ConclusionsIn summary, we found that p‐MAP 1A downregulation associated with p‐Tau upregulation was due to their altered binding forces to CDK5, and MAP 1A could enhance autophosphorylation by competitive binding to CDK5 and antagonise Tau phosphorylation. This leads to neuronal protection and reducing tissue damage levels in AD, which can help better understand the mechanisms of AD pathogenesis.
Functional and emotional impact of COVID‐19 lockdown on older adults with sarcopenia living in a nursing home: A 15‐month follow‐up
Authors: Cezón‐Serrano Natalia , Arnal‐Gómez Anna , Arjona‐Tinaut Laura , Cebrià i Iranzo Maria Àngels 
Published: September 2023

AbstractThis study aimed to detect the functional and emotional impact of COVID‐19 lockdown on institutionalized older adults with sarcopenia during a 15‐month follow‐up. A prospective longitudinal cohort study was conducted in a nursing home. Participants were screened for sarcopenia, and those with a score of ≥4 points according to SARC‐F questionnaire were included. Assessments were performed pre‐lockdown (T1), 12 months (T2) after, and at a 15‐month follow‐up (T3). Functional measurements included chair stand test, handgrip, biceps brachii and quadriceps femoris strengths, appendicular skeletal mass, gait speed, Short Physical Performance Battery, and Timed Up‐and‐Go test. Emotional assessments included Short‐Form Health Survey, Geriatric Depression Scale—Short Form, and the Mini‐Mental State Examination. The analyzed sample showed a reduction in bicep strength, and other upper and lower limb strength variables showed a decreasing trend with no changes regarding muscle mass. Physical performance showed a change, specifically a deterioration in the subtest related to balance. Cognitive and emotional components were affected and quality of life was decreased. It is of paramount importance to focus on sarcopenic older adults since their characteristics can deteriorate when isolation measures are conducted.
The Effect of Halo‐Pelvic Traction on Bone Mineral Density of Vertebrae and Corresponding Risk Factors
Authors: Huang Xianming , Xiu Peng , Shu Yi , Song Yueming , Zhou Zhongjie , Zhou Chunguang , Feng Ganjun , Wang Lei , Liu Limin , Tang Jing , Yang Xi 
Published: September 2023

ObjectivesDecreased bone mineral density (BMD) is associated with complications in implantation surgery for severe spinal deformity. In this quantitative study, we aimed to investigate the impact of halo‐pelvic traction on vertebral bone mineral density (BMD) and identify the risk factors for a decrease in BMD.MethodsPatients who underwent halo‐pelvic traction at our hospital between 2019 and 2022 were included in the study. Patients’ data, including height, weight, and BMD pre‐ and post‐traction, were collected and analyzed. Quantitative computed tomography (QCT) was used to determine the BMD. The paired rank sum test was used to evaluate the changes in each measurement parameter. Linear regression was used to identify risk factors for a decrease in BMD.ResultsFifteen patients were included in the study, nine women and six men, with an average age of 21.2 ± 7.3 years. Eleven patients had severe rigid scoliosis, while four had tuberculotic kyphosis. One expert measured the BMD values of 345 vertebrae using QCT. The average traction time was 143.3 ± 44.4 days. The average pre‐traction BMD was 183.1 ± 73.8 mg/cm3, and the average post‐traction BMD was 140.5 ± 61.3 mg/cm3 (p < 0.01) Patients’ height increased from an average of 151.3 ± 12.8 cm pre‐traction to 165.5 ± 13.7 cm post‐traction (p < 0.01), with traction length averaging 14.3 ± 6.2 cm (p < 0.01). The Cobb angle of the main curve declined from an average of 112.5° ± 24.4° pre‐traction to 67.7° ± 19.8° post‐traction (p < 0.01). Linear regression revealed a positive correlation between BMD loss and traction length and a negative correlation between BMD loss and correction rate.ConclusionsHalo‐pelvic traction can lead to a decrease in the BMD of the spinal vertebrae, with traction length positively correlated with BMD loss and correction rate negatively correlated with BMD loss. To prevent osteoporosis, physicians should ensure a limited traction length while utilizing better management techniques.
Clinical Analysis of the Frosch Approach in the Treatment of Posterolateral Tibial Plateau Fractures Combined with Lateral Tibial Plateau Fractures
Authors: Yuan Tangbo , Cai Dawei , Yang Fei , Wang Zeyong , Qin Jian 
Published: September 2023

ObjectiveThe treatment of posterolateral tibial plateau fractures is difficult, and providing sufficient exposure and effective fixation is a challenge. There is great controversy regarding the surgical approach for posterolateral tibial plateau fractures. The purpose of the study was to investigate the clinical effects of open reduction and internal fixation using the Frosch approach for the treatment of posterolateral tibial plateau fractures combined with lateral tibial plateau fractures.MethodsData from 19 patients with posterolateral tibial plateau fractures combined with lateral tibial plateau fractures treated from May 2018 to January 2022 were retrospectively analyzed. There were nine men and 10 women, ranging in age from 22 to 62 years, with an average age of 45.6 years. All patients were treated using the Frosch approach. Under direct vision, the posterolateral and lateral fractures were reduced, and full bone grafting was performed. We reshaped the oblique “T” shaped plate for the distal radius and placed it on the posterolateral tibial plateau to fix the posterolateral fractures. The lateral inverted “L” shaped locking plate was placed on the lateral tibial plateau to fix the lateral tibial plateau fractures. Within 2 weeks after the operation, the patients were instructed to perform knee joint function exercises within 90°. At the last follow‐up, the Rasmussen radiological criteria were used to evaluate the effectiveness of fracture reduction and fixation. And the knee joint function was evaluated using Rasmussen functional score.ResultsThe operation time ranged from 100 to 180 min, with an average of 134.2 min; intraoperative blood loss ranged from 20 to 150 mL, with an average of 66.8 mL. The follow‐up duration ranged from 14 to 58 months, with an average of 36.2 months. There were no complications, such as vascular or nerve injury or incision infection. Fracture healing was achieved in all patients, and the healing time ranged from 10 to 14 weeks, with an average of 11.2 weeks. During the follow‐up period, there was no loosening or breakage of the internal fixation, varus or valgus deformity of the knee joint, re‐collapse of the articular surface, or instability of the knee joint. At the last follow‐up, the effectiveness of fracture reduction and fixation was excellent in 13 patients and good in six patients. And the knee joint function was excellent in 17 patients and good in two patients.ConclusionThe Frosch approach for open reduction and internal fixation in the treatment of posterolateral tibial plateau fractures combined with lateral tibial plateau fractures has a definite clinical benefit and is worthy of promotion and application.
“Am I safe enough for you now?” BPD and the forced erasure of personal identity
Authors: Welch Shay 
Published: September 2023

AbstractIn this paper, I explore a number of issues related to a life lived with borderline personality disorder (BPD). Primarily, I am interested in discussing how one unwillingly changes their personal identity by forced medicating—demanded by others implicitly and explicitly. My motivation is something deep and invasive in me. I want to know, I have always wanted to know, why others want me to not be Me so badly. I have thought about this question for years, and though others may simply chalk it up to just one of the standard paranoid or narcissistic traits of borderline personality disorder, there is something more to this question that many of us agonize over most of our lives. There is a deeply normative component to this question that extends beyond the mere fear of abandonment; it is tied to a desire by others to erase—literally—who we are for their own comfort. In this sense, then, I invite you to travel along a path of what it can mean to be a BPDer, from a narrative, phenomenological, and cognitive lived, embodied perspective. My purpose is to show that the treatments for us that others desire cannot avoid (and usually do not want to avoid) the unraveling of who we really are. Whether we want to or not, we give up our self to keep other people with us. And for many, this is too much to ask, and can be one, though not the only, reason suicide and self‐harm seem to be necessary recourses. One in 10 people with BPD commit suicide. So this is a serious matter, indeed.
Red light enhances the antibacterial properties, biofabrication, and stability of Fagonia indica callus‐based silver nanoparticles
Authors: Iqbal Reema , Khan Tariq , Sherazi Tauqir A. , Jalal Abdullah , Ali Gul Shad 
Published: September 2023

AbstractPlant‐based nanoparticles can be tuned through the frequency of light for efficient synthesis, structural properties, and antibacterial applications. This research assessed the effect of material type (callus and whole‐plant extract) and the interaction with a specific range of light wavelength on AgNP synthesis. All types of AgNPs were characterized by their size, shape, associated functional groups, and surface charge. Interestingly, the size of red light and callus‐based AgNPs (RC‐AgNPs) was smaller (6.32 nm) compared to 14.59 nm for Ultraviolet light and callus‐based AgNPs (UV‐C‐AgNPs). Zeta potential analysis showed that RC‐AgNPs had higher stability (−29.2 mV) compared to UV‐C‐AgNPs (−16.7 mV). Similarly, red light‐based AgNPs had higher Oxidation reduction potential in both whole‐plant‐based and callus‐based AgNPs, indicating a more oxidizing nature compared to those synthesized under UV light. This was confirmed by the lower total phenolic and flavonoid content associated with them and their lower antioxidant activity. The higher antibacterial activities and lower minimum inhibitory concentrations of red light‐based AgNPs against highly resistant pathogenic bacteria demonstrated the role of red light in enhancing antibacterial activity. These results indicate that AgNPs synthesized in red light and callus extract are more active compared to those synthesized under other wavelengths and/or in whole‐plant extracts.