bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol intake and endogenous sex hormones in women: meta-analysis of cohort studies and Mendelian randomization
Authors: Tin Sandar Tin , Smith-Byrne Karl , Ferrari Pietro , Rinaldi Sabina , McCullough Marjorie L , Teras Lauren R , Manjer Jonas , Giles Graham , Marchand Loïc Le , Haiman Christopher A , Wilkens Lynne R , Chen Yu , Hankinson Sue , Tworoger Shelley , Eliassen A Heather , Willett Walter C , Ziegler Regina G , Fuhrman Barbara J , Sieri Sabina , Agnoli Claudia , Cauley Jane , Menon Usha , Fourkala Evangelia Ourania , Rohan Thomas E , Kaaks Rudolf , Reeves Gillian K , Key Timothy J 
Published: August 2023

Abstract
Background
The mechanisms underlying alcohol-induced breast carcinogenesis are not fully understood but may involve hormonal changes.
Methods
We investigated cross-sectional associations between self-reported alcohol intake and serum or plasma concentrations of oestradiol, oestrone, progesterone (in pre-menopausal women only), testosterone, androstenedione, DHEAS (dehydroepiandrosterone sulphate) and SHBG (sex hormone binding globulin) in 45 431 pre-menopausal and 173 476 post-menopausal women. We performed multivariable linear regression separately for UK Biobank, EPIC (European Prospective Investigation into Cancer and Nutrition) and EHBCCG (Endogenous Hormones and Breast Cancer Collaborative Group), and meta-analysed the results. For testosterone and SHBG, we also conducted two-sample Mendelian Randomization (MR) and colocalisation using the ADH1B (Alcohol Dehydrogenase 1B) variant (rs1229984).
Results
Alcohol intake was positively, though weakly, associated with all hormones (except progesterone in pre-menopausal women), with increments in concentrations per 10 g/day increment in alcohol intake ranging from 1.7% for luteal oestradiol to 6.6% for post-menopausal DHEAS. There was an inverse association of alcohol with SHBG in post-menopausal women but a small positive association in pre-menopausal women. MR identified positive associations of alcohol intake with total testosterone (difference per 10 g/day increment: 4.1%; 95% CI: 0.6%, 7.6%) and free testosterone (7.8%; 4.1%, 11.5%), and an inverse association with SHBG (-8.1%; -11.3%, -4.9%). Colocalisation suggested a shared causal locus at ADH1B between alcohol intake and higher free testosterone and lower SHBG (PP4: 0.81 and 0.97 respectively).
Conclusions
Alcohol intake was associated with small increases in sex hormone concentrations, including bioavailable fractions, which may contribute to its effect on breast cancer risk.
An Investigation of the Psychosocial Outcomes of Dry Eye Disease Treatment in Children with Computer Vision Syndrome
Authors: Temeltürk Rahime Duygu , Koçer Ali Mert , Özal Ece 
Published: August 2023

Abstract
Purpose
To examine the effects of topical eye drops treatment on the psychosocial status of pediatric patients with computer vision syndrome (CVS)-related dry eye disease (DED).
Methods
In this study, a total of 38 children (6 boys, 32 girls) with CVS-related dry eye symptoms were evaluated with the Schirmer test, tear break-up time (TBUT), and ocular surface disease index (OSDI) at the time of diagnosis and after artificial tear drops treatment. Additionally, the quality of life (QoL) levels and the anxiety and depression symptoms were assessed using self- report scales for children.
Results
The mean age and mean total screen exposure of patients were 13.95 ± 2.42 years and 5.65 ± 2.31 hours, respectively. After treatment, TBUT and Schirmer test values of the patients increased significantly, while OSDI values decreased (p < 0.001 for all). The total anxiety and the depression scores of the patients decreased (p = 0.001, and p = 0.003, respectively); whilst the physical, emotional, social and school functionality scores increased (p < 0.05 for all) with treatment. There was a significant correlation between the improvements in Schirmer test values and anxiety scores (r = -0.32, p = 0.045) and QoL total scores (r = 0.38, p = 0.016).
Conclusions
Enhanced QoL and decreased anxiety and depression scores, correlated with the amelioration of dry eye symptoms indicate that the CVS related DED has psychosocial effects, which may decrease after appropriate treatment, in pediatric patients. Future research endeavors that integrate comprehensive evaluations of dry eye and psychiatric symptoms can yield more comprehensive and precise insights into the interplay between psychiatric disorders and DED in children with CVS, as well as the outcomes of different treatment approaches.
A change in QT interval and ST-segment after radiofrequency catheter ablation in pediatric patients with Wolff–Parkinson–White syndrome
Authors: Fujita Shuhei , Kabata Eriko , Mizutomi Shinichiro , Usuda Kazuo , Chikata Akio , Futatani Takeshi , Hatasaki Kiyoshi 
Published: August 2023

Abstract
Background Few studies have examined QT, JT interval, and ST-segment changes due to radiofrequency catheter ablation (RFA) in manifest Wolff–Parkinson–White (WPW) syndrome in pediatric patients.Methods The study involved 27 patients (male-to-female, 13:14; age, 12 (5–16) years) who were diagnosed with WPW syndrome and underwent RFA in our hospital between 2009 and 2022. Electrocardiographic (ECG) changes were compared between the group with ventricular preexcitation due to an accessory pathway (manifest group, n = 16) and those without it (concealed group, n = 11).Results The QT interval before RFA was significantly longer in the manifest group than in the concealed group (402 [362–482] vs. 344 [323–427]; p = 0.001). The QT interval was significantly shortened in the manifest group before and after RFA (402 [362–482] vs. 360 [298–422] msec; p = 0.01). At 1 month, the QT interval difference between the manifest and concealed groups disappeared (366 [305–437] vs. 335 [301–436] msec; p = 0.001). ST-segment changes were found after RFA in 63% (10/16) of the patients in the manifest group but not in the concealed group. ECG changes presenting the Brugada-pattern were found in two patients. One month later, ECG abnormalities persisted in only one patient.Conclusions In cases of prolonged QT interval or ST-segment abnormalities lasting > 1 month after RFA, the coexistence of manifest WPW syndrome with long QT syndrome or Brugada syndrome may be considered.
Ab initio calculations of neutrinoless ββ decay refine neutrino mass limits
Authors: Holt Jason , Belley Antoine , Miyagi Takayuki , Stroberg Steven 
Published: August 2023

Abstract
Neutrinos are perhaps the most elusive known particles in the universe. We know they have some nonzero mass, but unlike all other particles, the absolute scale remains unknown. In addition, their fundamental nature is uncertain; they can either be their own antiparticles or exist as distinct neutrinos and antineutrinos. The observation of the hypothetical process of neutrinoless double-beta (0νββ) decay would at once resolve both questions, while providing a strong lead in understanding the abundance of matter over antimatter in our universe1. In the scenario of light-neutrino exchange, the decay rate is governed by, and thereby linked to the effective neutrino mass, via the theoretical nuclear matrix element (NME). In order to extract the neutrino mass, if a discovery is made, or to assess the discovery potential of next-generation searches, it is essential to obtain accurate NMEs for all isotopes of experimental interest. However, two of the most important cases, 130Te and 136Xe, lie in the heavy region and have only been accessible to phenomenological nuclear models. In this work we utilize powerful advances in ab initio nuclear theory to compute NMEs from the underlying nuclear and weak forces driving this decay, including the recently discovered short-range component2. We find that ab initio NMEs are generally smaller than those from nuclear models, challenging expected sensitivities of future ton-scale searches as well as claims to probe the inverted hierarchy of neutrino masses3. With this step, ab initio calculations with theoretical uncertainties are now feasible for all isotopes relevant for next-generation 0νββ decay experiments.
An easy and time-effective meditative approach for relaxation and rejuvenation of the body and mind
Authors: Jayswal Anurag , Devi Kabita , Deka Ajanta , Satapathy Siddhartha Sankar , Singh Deepeshwar , Deka Bhabesh , Deka Ramesh Chandra , Ray Suvendra Kumar 
Published: August 2023

Abstract
In this study, we are implementing an easy technique of coordination between breathing and thumb movement on finger divisions, which is performed with closed eyes for a short duration of five minutes. This technique has been practiced by a small group of 28 participants in a natural classroom setting and its immediate impact on calming down and inducing sleep was observed distinctly (p < 0.05). The electroencephalogram (EEG) results distinctly demonstrated a change in brain waves by the technique practiced by a single participant. The low-frequency delta wave increased, and all other higher-frequency waves decreased during meditation. The maximum effect was observed in the prefrontal lobe, which is the center for decision-making, creativity, and reasoning. This indicated that the proposed technique is effective to rejuvenate a person within a short duration. Owing to its easy as well as time-effective approach, the method can be followed by people who need to relax within time constraints. The method might be used in the future for the prognosis of people suffering from restlessness and anxiety.
Photosynthetic attributes on drought tolerance of rice landraces (Oryza sativa L.)
Authors: JeevaPriya S. , Vincent S. , Joel A. John , Srith N. , Senthil A. 
Published: August 2023

Abstract
Drought stress is mainly a serious limiting factor for rice production, which creates huge economic losses by becoming more serious issue with respect to global climate change. In the view of the current situations and forecasted global food demand, it is necessary to enhance the crop productivity on the drought prone rain fed lands with utmost priority.Rice is a main staple cereal crop in the world.Climate change mainly alters the plant phyllosphere and its resource allocations. The main aim of this experiment was to evaluate the “Photosynthetic attributes on drought tolerance of rice landraces” (Oryzasativa L.). A laboratory screening, hydroponic studies and pot culture experiments were conducted in the Department of Crop Physiology, Tamil Nadu Agricultural University, Coimbatore, during 2020–2021 to investigate the Photosynthetic attributes. Rice land races, namely Anna(R) 4, 337- IC116006, 224 - IC463809 were studied. The present findings showed that drought stress reduced the photosynthetic parameters and enhanced the chlorophyll index and soil temperature in all the land races. Among the land races, Anna(R) 4 performed better under drought stress conditions when compared to other.
Bridging the Gap: Advancing the Transparency and Trustworthiness of Network Intrusion Detection with Explainable AI
Authors: Islam Md. Tohidul , Syfullah Md. Khalid , Rashed Md. Golam , Das Dipankar 
Published: August 2023

Abstract

With the explosive rise of internet usage and the development of web applications across various platforms, ensuring network and system security has become a critical concern. Networks and web services are particularly susceptible to targeted attacks, as hackers and intruders persistently attempt to gain unauthorized access. The integration of artificial intelligence (AI) has emerged as a crucial tool for detecting intrusions and constructing effective Intrusion Detection Systems (IDSs) to counter cyber-attacks and malicious activities. IDSs developed using machine learning (ML) and deep learning (DL) techniques have proven to be highly effective in detecting network attacks, offering machine-centric solutions. Nevertheless, mainstream adoption, confidence and trust in these systems have been greatly impeded by the fact that ML/DL implementations tend to be “black boxes,” and thus lacking human interpretability, transparency, explainability, and logical reasoning in their prediction outputs. This limitation has prompted questions about the responsibility and comprehension of AI-driven intrusion detection systems. In this study, we propose four novel architectures that incorporate Explainable Artificial Intelligence (XAI) techniques to overcome the challenges of limited interpretability in ML/DL based IDSs. We focus on the development of ExplainDTC, SecureForest-RFE, RationaleNet, and CNNShield architectures in network security solutions, and inquiry into their potential to convert the untrustworthy architectures into trustworthy. The models are applied to scan network traffic and identify, and report intrusions based on the traits extracted from the UNSW-NB15 dataset. To explain how a decision is made by the models and to add expansibility at every stage of machine learning pipeline, we integrate multiple XAI methods such as LIME, SHAP, ElI5, and ProtoDash on top of our architectures. The generated explanations provide quantifiable insights into the influential factors and their respective impact on network intrusion predictions.
Phosphorus forms and adsorption properties of paddy field soils and potential risk to Indawgyi Lake, Myanmar
Authors: Hashar Mohammad Rafiul , Nasrin Shamima 
Published: August 2023

Abstract

The largest freshwater and oligotrophic lake in northern Myanmar, called Indawgyi Lake, is at potential risk of eutrophication due to the phosphorus (P) export from nearby paddy fields. In this study, the P status of the soil of paddy fields and its potential mobility to the lake water to cause eutrophication have been evaluated. The Indawgyi Lake is the third largest lake in Asia and became a UNESCO biosphere reserve in June 2017 for its outstanding contribution to providing habitat for threatened birds and aquatic species. Although many other sources, e.g. high tourist interest, loss of natural forest areas, the gathering of pilgrims and lack of proper wastewater treatment plants are contributing to the P nutrients input to the lake, the increase of paddy fields around the lake area and use of synthetic fertilizer which exports to the lake is considered to the primary source of P export to the lake. In this study, the soil P was examined with different P extracted methods and P export to the lake was calculated. The extracted P differed in order and magnitude with different methods, and the order was increased in accordance with CaCl2 < DL-P < Olsen-P < BD-P < HCL-P < TP and for iron, it was HCl-Fe < TFe. All extracted Olsen-P was below 10 mg kg− 1, which is below the critical level (30–172 mg kg− 1) for P loss. On the other hand, the soil has a high P sorption capacity, and the maximum sorption capacity among the soil samples that were done with the Langmuir equation is 0.790 mg g− 1. Our findings suggested that paddy fields are not contributing to the eutrophication of the lake at present. However, comparing the historical map around the lake area from 1944 to 2017, it has been found that the area of paddy fields around the lake has increased almost three-fold from 1944 to 2017. As a result of increasing paddy fields and synthetic fertilizer use, we can say that P export from paddy fields can cause severe eutrophication to the lake in the near future.
Effects of Vermiconversion on Coffee husk, Paper waste and Vegetable waste Using Red Worm (Eisenia fetida) in Begi Woreda, Ethiopia
Authors: Geleta Zelalem Telila , Daka Yohannes Shifera 
Published: August 2023

Abstract
Vermicomposting is the bioconversion of organic waste into a bio-fertilizer due to earthworms’ activity and it is operated in mesophilic conditions. PH and moisture content levels shall be optimized. The vermicomposting process takes place in vermin-reactors. In the vermicomposting method microorganisms begin the process, but it is the red worm that plays the largest role in converting organic matter. In this study vermicomposting process was conducted to evaluate performance of epigamic earth worm species of Esinia foetida in 60 days to change on the three biodegradable wastes (Coffee husk, Paper waste and vegetable wastes) in Begi town. The two wastes (coffee husk and paper wastes) were mixed with cow dung 3:1 ratio and vegetable wastes without cow slurry treated with Esinia foetida (tiger worm. Thirty (30) numbers of matured earth worms were inoculated on the three substrates and monitored for 60 days. Each waste was observed three times at intervals of 0 days, 30 days and 60 days. Characterization results showed that there is a change of pH, EC, OM, OC, TN, C:N, AP, EK, Ash from initial days to final results of observation which results at 0 and 60 day (pH 7.51–7.03, EC 1.91mS/cm -1.24 mS/cm, OM 47.06–29.21%, OC 27.3-16.93%,TN 1.38–2.199%, C:N21.39-8.63,AP11.17-20.85ppm and EK 2.26-4.43mg/k ) were found. The finding from the study showed that, the vermicomposting produced have matured and quality when compared with WHO and ISIRI standards. The obtained vermicompost had an excellent nutrient status, confirmed by the chemical analyses, and contained essential nutrients. Vermicomposting could good option to recover biodegradable wastes from the town and simultaneously produces organic fertilizer.
Adolescentes em conflito com a lei privados de liberdade em uma unidade no Distrito Federal: uma proposta de intervenção do cuidado em saúde mental
Authors: SOUZA Daniela Raguer Valadão de , RAMOS Willamis Tenório , FONTENELES Amanda de Oliveira , SOUZA Stéphanie Louise Fonseca , GERALDINI Janaina Rodrigues , FREITAS Carla Kalline Alves Cartaxo , FERNANDES Waleska Batista 
Published: August 2023

A adolescência caracteriza-se como um processo histórico-cultural, no qual o desenvolvimento humano é influenciado por vários fatores que atravessam as questões biológicas, psíquicas, culturais e sociais. Esta produção científica teve, como objetivo principal, pensar o espaço socioeducativo enquanto zona de reconhecimento do eu e de descoberta da autonomia, por meio de encontros terapêuticos. Trata-se de um relato de experiência sobre o processo de planejamento, construção e execução de intervenções sobre cuidado em saúde mental com adolescentes em Conflito com a lei, desenvolvido na Unidade de Internação Recanto das Emas (UNIRE). Ao total foram planejados 11 encontros, tendo a participação de 16 adolescentes do gênero masculino que estavam admitidos na unidade. Observou-se que os encontros realizados podem ser considerados uma proposta de cuidado em saúde mental para adolescentes que estão em conflito com a lei e privados de liberdade no Distrito Federal.
IMPORTANTE NÃO É SABER AONDE CHEGAR, IMPORTANTE É A TRAJETÓRIA
Authors: Singer Helena 
Published: August 2023

O título deste artigo remete a frase de Paul Singer que sintetiza uma trajetória pautada pelo engajamento da economia em prol do desenvolvimento pleno da sociedade. E, para desenvolvê-la, um dos elementos que considerava essencial era a economia solidária, conceito que desenvolve nos textos que compõem o livro Economia solidária: introdução, história e experiência brasileira. Paul Singer encontrou-se com a economia solidária depois dos 60 anos de idade e foi um encontro definitivo, que o faria resgatar e reinventar diversos aspectos de sua produção intelectual, bem como da trajetória como gestor público e de sua militância política. Os nove textos que são apresentados neste artigo foram escritos entre 2001 e 2013 e, no conjunto, oferecem uma visão ampla sobre os princípios, conceitos e histórico da economia solidária no mundo, tendo a experiência brasileira como referência para políticas públicas comprometidas com a superação da pobreza e da heteronomia no trabalho, o fortalecimento da democracia e a conquista de uma vida melhor para todos. Nestes textos, Singer escreve sobre a autogestão como desenvolvimento humano e a economia solidária como fruto da sociedade civil organizada, um modo de produção que visa enfrentar o capitalismo. Confirma, assim, a importância das experiências pelo aprendizado que proporciona aos trabalhadores ao assumirem coletivamente a gestão de empreendimentos produtivos e operá-los segundo princípios democráticos e igualitários. Segundo Paul Singer, o florescer de uma profusão de economias solidárias ou sociais ou humanas é a garantia de sua viabilidade, pois a vocação da humanidade não é a uniformização.
Polymeric Gel Scaffolds and Biomimetic Environments for Wound Healing
Authors: Alka  , Verma Abhishek , Mishra Nidhi , Singh Neelu , Singh Priya , Nisha Raquibun , Pal Ravi Raj , Saraf Shubhini A. 
Published: August 2023

Abstract:
Infected wounds that do not heal are a worldwide problem that is worsening, with more people dying
and more money being spent on care. For any disease to be managed effectively, its root cause must be addressed.
Effective wound care becomes a bigger problem when various traditional wound healing methods and
products may not only fail to promote good healing. Still, it may also hinder the healing process, causing
wounds to stay open longer. Progress in tissue regeneration has led to developing three-dimensional scaffolds
(3D) or constructs that can be leveraged to facilitate cell growth and regeneration while preventing infection
and accelerating wound healing. Tissue regeneration uses natural and fabricated biomaterials that encourage the
growth of tissues or organs. Even though the clinical need is urgent, the demand for polymer-based therapeutic
techniques for skin tissue abnormalities has grown quickly. Hydrogel scaffolds have become one of the most
imperative 3D cross-linked scaffolds for tissue regeneration because they can hold water perfectly and are porous,
biocompatible, biodegradable, and biomimetic. For damaged organs or tissues to heal well, the porosity
topography of the natural extracellular matrix (ECM) should be imitated. This review details the scaffolds that
heal wounds and helps skin tissue to develop. After a brief overview of the bioactive and drug-loaded polymeric
hydrogels, the discussion moves on to how the scaffolds are made and what they are made of. It highlights
the present uses of in vitro and in-vivo employed biomimetic scaffolds. The prospects of how well bioactiveloaded
hydrogels heal wounds and how nanotechnology assists in healing and regeneration have been discussed.