bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceleration-induced spectral beats in strongly driven harmonic oscillators
Authors: Santos Paulo , Kuznetsov Alexander , Biermann Klaus 
Published: July 2023

Abstract

The harmonic modulation of coherent systems gives rise to a wealth of interesting physical phenomena, e.g., the AC-Stark effect and Mollow triplets, with important implications for coherent control and quantum frequency conversion. Optomechanical systems enable access to extreme driving conditions by exploiting their high oscillations frequencies and long temporal coherence. Here, we experimentally demonstrate a novel regime of temporal coherence in oscillators harmonically driven at extreme energy modulation amplitudes, which is characterized by temporal correlations with time-scales much shorter than the modulation period. These arise from accelerated energy changing rates during the harmonic cycle and manifest themselves as comb of spectral resonances, termed the acceleration beats, with energy scale tunable by the energy modulation amplitude. We provide experimental evidence for the acceleration beats by modulating a confined exciton-polariton Bose-Einstein condensate (BEC) using an acoustic wave. The detection of the beats is underpinned by the high sensitivity of the BEC energy to the acoustic driving field, which simultaneously preserves the high BEC temporal coherence. The acceleration beats are a general feature associated with accelerated energy changes: analogous features are thus also expected to appear under highly accelerated motion e.g., in connection with Cherenkov and Hawking radiation.
Research on vision-based UAV power line detection technology
Authors: Li Yanke , Wang Kai 
Published: July 2023

Abstract
In order to ensure the reliability and safety of the power grid operation, the power company will carry out regular inspection of the transmission line network. The traditional inspection method is generally manual inspection by foot patrol, which is not only slow but also time-consuming and laborious. In recent years, with the development of unmanned aerial vehicle(UAV) and unmanned vehicle control technology and the improvement of inspection accuracy, UAV technology has been widely used in the intelligent inspection of power grid. In order to ensure the reliability and safety of power grid operation in the complex and huge power grid system, in order to find the fault of transmission line as soon as possible and give feedback, The UAV detection technology with image recognition technology has become an urgent need for the development of power system. The vision-based UAV power line detection technology has a wide range of application prospects. In this paper, the relevant literature in recent years is reviewed extensively, and the status quo of vi-sion-based UAV detection technology is reviewed. This paper summarizes the existing power line detection methods, the system structure of UAV power line detection and the image recognition technology of data acquisition, and focuses on the development of transmission line data processing technology based on deep learning, in order to provide a starting point for researchers to develop automatic autonomous intelligent inspection of transmission line system. Finally, the development of this field and the next possible challenges are discussed, and the future is prospected.
Bidirectional Effect of Uric Acid on C2C12 Myotubes and Its Partial Mechanism
Authors: Li Yuanfen , Zhang Yingxiao , Wu Yaoxuan , Yu Jing , Guo Ai , Fu Rao , Xiao Qian 
Published: July 2023

Abstract
Objectives: To explore the effects and mechanisms of different concentrations of uric acid on skeletal muscle cells.
Methods: C2C12 myoblasts were differentiated into myotubes and then exposed to medium containing uric acid (0 μM, 200 μM, 400 μM, 600 μM, 800 μM, 1000 μM, 1200 μM, 1400 μM). The myotube diameters was observed under light microscopy; the expression of myosin heavy chain (MyHC), autophagy-related proteins (LC3BII/LC3BI, P62), cGAS, and p-sting/sting proteins was analysed using Western blotting or immunoprecipitation, and oxidative stress and mitochondrial damage were evaluated using ROS, mtDNA and JC-1 assays. Cell viability was measured via CCK8 assay, and 1000 μM uric acid was selected for follow-up experiments. Furthermore, C2C12 myotubes were divided into a blank control (Ctrl) group, a high-uric-acid group (HUA) and an HUA plus cGASn inhibitor (HUA+RU.521) group. Then, the myotube diameter was observed, oxidative stress and mitochondrial damage were evaluated, and MyHC and autophagy-related protein expression was analysed.
Results: C2C12 myotubes cultured in 400 μM uric acid medium had the greatest myotube diameter and the highest MyHC protein expression. At 1000 μM uric acid, the diameter and MyHC protein expression were significantly decreased, LCB3II/LCB3I expression was notably increased, and the expression levels of p62 protein expression was considerably decreased. RU.521 partially alleviated the HUA-induced C2C12 myotubes changes.
Conclusions: Uric acid bidirectionally affected C2C12 myotubes: 400 μΜ uric acid promoted myotube growth, while 1000 μΜ uric acid triggered myotube atrophy with increased autophagy. Inhibiting cGAS-sting signalling attenuated HUA-induced C2C12 myotube autophagy and atrophy.
Practice determinants for adherence to the Guide for the Comprehensive Clinical Care of Dengue Patients, Urabá (Colombia). A multifaceted approach to implementation research
Authors: Rubiano Luisa Consuelo , Montoya Dayana , Urrego Catalina , Morales Santiago Alberto , Ríos-Tapias Paola Astrid , Monsalve Katherine , Arboleda Margarita 
Published: July 2023

Abstract
Introduction: Dengue is a significant public health issue in the Urabá region, accounting for 37.5% of morbidity and 41.7% of mortality resulting from dengue in the department of Antioquia (Colombia) in 2018. Clinical Practice Guidelines (CPGs) are tools based on Evidence-Based Medicine, intended for medical personnel to bridge the gap between proven intervention efficacy and clinical decision-making. This study aims to identify barriers and facilitators in the implementation of CPGs for dengue patient care by healthcare officials in the municipalities of the banana axis in the Urabá region. Methodology: A multifaceted approach study was conducted, employing semi-structured interviews to identify determinants affecting adherence to the Comprehensive Clinical Care Guide for Patients with Dengue (GACIPD). Focus groups with healthcare workers were conducted to assess determinants based on clinical experience. Questionnaires on determinants of GACIPD adherence, using an adapted version of the Chronic Disease Implementation Checklist (TICD), were also employed. Qualitative analysis of the interviews and focus groups used a concept-based coding framework. The questionnaire responses were analyzed using Likert scaling and frequency counts of determinants within and across domains. Participants included general practitioners, other health professionals, researchers, academics, and administrators. Results: Among the seven domains studied, the identification of barriers and facilitators emphasized institutional factors and individual factors. Organizational change capacity was identified as a major barrier, with only 3.6% of respondents indicating that their institution adjusted prioritization of adequate care according to the guideline. The GACIPD domain received the highest facilitator rating, with 66.7% acceptance due to its practicality, simplicity, clarity, documentation, and ease of implementation. However, there were gaps in addressing coinfections with other tropical diseases. Conclusions: Although barriers outweighed facilitators for GACIPD adherence, determinants for its use were generally positive, as most participants reported it as being a complete, documented, and easy-to-implement guide. However, the region requires greater emphasis on the management of chronic health conditions, comorbidities, and coinfections of dengue with other endemic diseases.
Ibuprofen delays senolytic effects of exercise in human skeletal muscle: A randomized control crossover trial
Authors: Jean Wei-Horng , Ang Pei-Yao , Goto Kazushige , Lin Chao-An , Dewi Luthfia , Liao Yu-Chieh , Ye Mengxin , Nicholls Andrew , Huang Chih-Yang , Kuo Chia-Hua 
Published: July 2023

Abstract
Background: Inflammation is required for muscle regeneration after injury.
Purpose: To examine the role of inflammation on the exercise-induced senolytic effect in human skeletal muscle. Methods: Nonsteroidal anti-inflammatory treatments were administered using a placebo-controlled counterbalanced crossover trial (washout: > 3 weeks). Sedentary men (n = 12) aged 20-26 consumed ibuprofen (total dose: 1200 mg) or placebo before and after high-intensity interval exercise (HIIE) at 120% maximum aerobic power (total work ~ 70 kJ). Muscle biopsies were taken 3 hours and 24 hours after HIIE for tissue analysis compared to their pre-exercise baseline.
Results: Following a 3-h recovery after HIIE, DNA strand breaks and γ-H2AX+ myofibers were comparable to baseline suggesting a quick post-exercise recovery without observed differences between placebo and ibuprofen. We found concurrent decreases in p16INK4a mRNA (-82%, p = 0.01, d = 1.23) and CD11b mRNA (-87%, p = 0.02, d = 1.03) within 3 hours, persisting for 24 hours. Immunohistochemistry analysis indicated that p16INK4a -expressing cells were located surrounding myofibers. Ibuprofen delayed both senolytic and anti-inflammatory effects of HIIE in muscle tissues. A strong correlation between p16INK4a mRNA and CD11b mRNA in muscle tissues (r = 0.88, p < 0.001) suggests the senolytic effect of exercise on lowering pro-inflammatory myeloid differentiation in human muscles.
Conclusion: This study provides the first evidence suggesting high intensity exercise is a senolytic intervention to lower baseline inflammation persisting over an extended period. Pharmacological suppression of inflammation during muscle contraction delays this senolytic effect.
Founding a mathematical diffusion model in linguistics. The case study of German syntactic features in the North-Eastern Italian dialects.
Authors: Lazzizzera Ignazio 
Published: July 2023

Abstract
The initial motivation for this work was the linguistic case of the spread of Germanic syntactic features into Romance dialects of the North-Eastern Italy, occurred after the immigration of German people in the Tyrol during the High Middle Age. To obtain a representation of the data over the territory suitable for a mathematical formulation, an interactive map is produced as a first step, using tools of what is called Geographic Data Science. A smooth two-dimensional surface G is introduced, expressing locally which fraction of territory uses a given German language feature: it is obtained by a piece-wise cubic curvature-minimizing interpolant of the discrete function that says if at any surveyed locality that feature is used or not.
This surface G is thought of as the value at the present time of a function describ- ing a diffusion-convection phenomenon in two dimensions (here said tidal mode), which is subjected in a very natural way to the same equation used in physics, introducing a contextual diffusivity concept: it is shown that with two different assumptions about diffusivity, solutions of this equation, evaluated at the present time, fit well with the data interpolated by G, thus providing two convincing different pictures of diffusion-convection in the case under study, albeit simplifi- cations and approximations.
Very importantly, it is shown that the linguistic diffusion model known to linguists as Schmidt ’waves’ can be counted among the solutions of the diffusion equation: superimposing Schmidt ’waves’ to a ’tidal linguistic flooding’ can reproduce com- plexities of real linguistic diffusion events, however at the cost of resorting to numerical techniques, which must also be said for a very realistic diffusion- convection model, using appropriate diffusivity, based on historical, local cultural and geographical grounds.
Numerical Inference on Generalized Gamma Distribution Parameters Using Runge-Kutta Method
Authors: Maswadah M. 
Published: July 2023

AbstractIn parameter estimation techniques, there are many methods for estimating the distribution parameters in life data analysis. However, most of them are less efficient than Bayes’ method based on the informative prior. Thus, the main objective of this study is to present an optimal estimation method using a numerical method such as the Runge-Kutta technique for estimating the Generalized Life Model parameters and comparing them with the Bayesian estimates based on the informative gamma and kernel priors. An extensive Monte Carlo simulation has been carried based on the generalized progressive hybrid censoring scheme in terms of two criteria, namely, absolute bias and mean squared error. The simulation results indicated that the Runge-Kutta method is highly favorable, which provides better estimates and outperforms the Bayes’ method based on the generalized progressive hybrid censoring scheme. Finally, two real dataset analyses are presented to illustrate the efficiency of the proposed methods.
Efficient Generation of Chondrocytes From Bone Marrow–Derived Mesenchymal Stem Cells in a 3D Culture System: Protocol for a Practical Model for Assessing Anti-Inflammatory Therapies
Authors: Patnaik Rajashree , Jannati Shirin , Sivani Bala Mohan , Rizzo Manfredi , Naidoo Nerissa , Banerjee Yajnavalka 
Published: July 2023

Background
Chondrocytes are the primary cells responsible for maintaining cartilage integrity and function. Their role in cartilage homeostasis and response to inflammation is crucial for understanding the progression and potential therapeutic interventions for various cartilage-related disorders. Developing an accessible and cost-effective model to generate viable chondrocytes and to assess their response to different bioactive compounds can significantly advance our knowledge of cartilage biology and contribute to the discovery of novel therapeutic approaches.

Objective
We developed a novel, streamlined protocol for generating chondrocytes from bone marrow–derived mesenchymal stem cells (BMSCs) in a 3D culture system that offers significant implications for the study of cartilage biology and the discovery of potential therapeutic interventions for cartilage-related and associated disorders.

Methods
We developed a streamlined protocol for generating chondrocytes from BMSCs in a 3D culture system using an “in-tube” culture approach. This simple pellet-based 3D culture system allows for cell aggregation and spheroid formation, facilitating cell-cell and cell–extracellular matrix interactions that better mimic the in vivo cellular environment compared with 2D monolayer cultures. A proinflammatory chondrocyte model was created by treating the chondrocytes with lipopolysaccharide and was subsequently used to evaluate the anti-inflammatory effects of vitamin D, curcumin, and resveratrol.

Results
The established protocol successfully generated a large quantity of viable chondrocytes, characterized by alcian blue and toluidine blue staining, and demonstrated versatility in assessing the anti-inflammatory effects of various bioactive compounds. The chondrocytes exhibited reduced inflammation, as evidenced by the decreased tumor necrosis factor-α levels, in response to vitamin D, curcumin, and resveratrol treatment.

Conclusions
Our novel protocol offers an accessible and cost-effective approach for generating chondrocytes from BMSCs and for evaluating potential therapeutic leads in the context of inflammatory chondrocyte–related diseases. Although our approach has several advantages, further investigation is required to address its limitations, such as the potential differences between chondrocytes generated using our protocol and those derived from other established methods, and to refine the model for broader applicability and clinical translation.
Coping Strategies Used by Health Care Workers in Ecuador During the COVID-19 Pandemic: Observational Study to Enhance Resilience and Develop Training Tools
Authors: Vicente María Asunción , Gil Hernández Eva , Carrillo Irene , Fernández César , López-Pineda Adriana , Guilabert Mercedes , Martín-Delgado Jimmy , Solis Carlos , Camba Karla , Cañizares Fuentes Wilson Ricardo , Mira José Joaquín 
Published: July 2023

Background
The COVID-19 pandemic has generated immense health care pressure, forcing critical decisions to be made in a socially alarmed environment. Adverse conditions have led to acute stress reactions, affective pathologies, and psychosomatic reactions among health personnel, which have been exacerbated by the successive waves of the pandemic. The recovery of the entire health system and its professionals has been hindered, making it essential to increase their resilience.

Objective
This study aimed to achieve 2 primary objectives. First, it sought to identify coping strategies, both individual and organizational, used by health care workers in Ecuador to navigate the acute stress during the early waves of the pandemic. Second, it aimed to develop training materials to enhance team leaders' capabilities in effectively managing high-stress situations.

Methods
The study used qualitative research techniques to collect information on institutional and personal coping strategies, as well as consensus-building techniques to develop a multimedia psychological tool that reinforces the resilience of professionals and teams in facing future crises.

Results
The findings from the actions taken by health care workers in Ecuador were categorized into 4 types of coping strategies based on Lazarus' theories on coping strategies. As a result of this study, a new audiovisual tool was created, comprising a series of podcasts, designed to disseminate these strategies globally within the Spanish-speaking world. The tool features testimonials from health care professionals in Ecuador, narrating their experiences under the pressures of providing care during the pandemic, with a particular emphasis on the coping strategies used.

Conclusions
Ensuring the preparedness of health professionals for potential future outbreaks is imperative to maintain quality and patient safety. Interventions such as this one offer valuable insights and generate new tools for health professionals, serving as a case study approach to train leaders and improve the resilience capacity and skills of their teams.
Associations of Habitual Calcium Supplementation With Risk of Cardiovascular Disease and Mortality in Individuals With and Without Diabetes
Authors: Qiu Zixin , Lu Qi , Wan Zhenzhen , Geng Tingting , Li Rui , Zhu Kai , Li Lin , Chen Xue , Pan An , Manson JoAnn E. , Liu Gang 
Published: July 2023

OBJECTIVE
To prospectively examine the associations of habitual calcium supplementation with cardiovascular disease (CVD) events and mortality in individuals with and without diabetes.

RESEARCH DESIGN AND METHODS
The main analysis included 434,374 participants from the UK Biobank. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs. Interactions of calcium supplement use with diabetes status were tested on multiplicative and additive scales.

RESULTS
Over a median follow-up of 8.1 and 11.2 years, 26,374 incident CVD events and 20,526 deaths were documented, respectively. After multivariable adjustment, habitual calcium supplementation was significantly associated with higher risks of CVD incidence (HR 1.34; 95% CI 1.14, 1.57), CVD mortality (HR 1.67; 95% CI 1.19, 2.33), and all-cause mortality (HR 1.44; 95% CI 1.20, 1.72) in participants with diabetes, whereas no significant association was observed in participants without diabetes (HR 0.97 [95% CI 0.92, 1.03] for CVD incidence; HR 1.05 [95% CI 0.90, 1.23] for CVD mortality; HR 1.02 [95% CI 0.96, 1.09] for all-cause mortality). Significant multiplicative and additive interactions were found between habitual calcium supplementation and diabetes status on risks of CVD events and mortality (all Pinteraction &lt; 0.05). In contrast, no significant interactions were observed between dietary or serum calcium and diabetes status.

CONCLUSIONS
Habitual use of calcium supplements was significantly associated with higher risk of CVD events and mortality in people with diabetes but not in people without diabetes. Further studies are needed to balance potentially adverse effects of calcium supplement against likely benefits, particularly among patients with diabetes.
Effect of a Diode Laser (445 nm) on Polymerization Efficiency of a Preheated Resin Composite Used for Luting of Indirect Composite Restorations
Authors: Michailidou S , Dionysopoulos D , Papadopoulos C , Naka O , Andriotis E , Fatouros D , Tolidis K 
Published: July 2023

SUMMARY

Purpose
The aim of this study was to evaluate the polymerization efficiency of a preheated resin composite used as a luting agent for indirect restorations light-cured by a blue diode laser (445 nm).

Methods
Bronze molds were used to prepare cylindrical specimens of a laboratory composite (Ceramage) with dimensions 2, 3, and 4 mm in height and 8 mm in diameter. The molds had additional height of 120 μm for the placement of the preheated resin composite. A nanohybrid resin composite (Enamel Plus HRi) was preheated at 55°C to use as a luting agent. Photopolymerization was followed for 20 seconds using three light sources: a diode laser emitting at 445 nm (SiroLaser Blue) and two light-emitting diode (LED) units (Bluephase Style and Valo). Degree of conversion (DC) of the preheated resin composite was evaluated using Fourier transform infrared spectroscopy.

Results
The results indicated that the main effects of the analysis were significant for both material thickness (p&lt;0.001) and polymerization method (p&lt;0.001). The preheated resin composite was not polymerized under 4-mm-thick specimens, independent of the light-curing unit. For 2-mm material thickness, there was no difference among the three light-curing units (p=0.383), while 3-mm Bluephase Style presented very low DC.

Conclusions
Diode laser (445 nm) achieved better polymerization efficiency at the same fluence compared to the LED unit at 3-mm depth, implying a better mechanical behavior and potential improved adhesion of the luting material to dentin.