bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shaping ability of BlueShaper, TruNatomy, DC Taper and HyFlex EDM in long oval canals: An ex vivo study
Authors: García‐Castañeda Zenaida , Gomes‐Azevedo Susana , Flores‐Treviño Jorge , González Gustavo Martínez , Brasil Sabrina C. , Souza Thaís M. , Rôças Isabela N. , Siqueira José F. 
Published: June 2023

AbstractAimThis study evaluated and compared the shaping ability of four rotary instrument systems in long–oval root canals using microcomputed tomographic (micro‐CT) evaluation. Currently, there is no data available on the canal shaping abilities of BlueShaper and DC Taper instruments.MethodologySixty‐four single‐rooted mandibular premolars were matched based on similar root canal morphologic features as determined by (micro‐CT) and randomly assigned to 1 of 4 experimental groups (n = 16) according to the instrument system used: BlueShaper, TruNatomy, DC Taper and HyFlex EDM One File. Changes in the root canal surface and volume, remaining dentine thickness, and number of prepared areas were assessed.ResultsNo significant differences were found amongst the four instrument systems for the parameters evaluated (p > .05). There was a significant reduction in the number of unprepared areas and the remaining dentine thickness after each increase in size of the instruments tested (p < .05).ConclusionsThe four instrument systems perform similarly in long oval root canals. Although none could prepare all canal walls, larger preparations incorporated significantly more surfaces in the final shape.
Antidiabetic, antihypertensive and antioxidant activity of cookies formulated with ground Mangifera indica L. leaves
Authors: Ramón‐Canul Lorena Guadalupe , Guzmán‐Victoria Elisa , Ramírez‐Rivera Emmanuel de Jesús , Cabal‐Prieto Adán , Rodríguez‐Miranda Jesús , Llaguno‐Aguiñaga Alejandro , Sánchez‐Orea José Manuel , Ramírez‐García Sergio Alberto , Prinyawiwatkul Witoon , Herrera‐Corredor José Andrés 
Published: June 2023

SummaryThe objective of this study was to evaluate the antioxidant and inhibitory activity of ACE, α‐amylase and α‐glucosidase as well as their nutritional and physicochemical quality of cookies formulated with ground Mangifera indica L. leaves. Overall, the cookies formulated with 15 (CGML‐15) and 10% (CGML‐10) ground mango leaf exhibited higher content of crude fibre (5.50 and 3.06 g 100 g−1). DPPH, ABTS and FRAP results in cookies ranged from 18.72 to 5.18 mg TEAC 100 g−1, 21.59 to 7.89 mg TEAC 100 g–1 and 22.56 to 8.59 mg TEAC 100 g−1, respectively. The CMGL‐15 cookie presented the highest inhibitory activity of α‐glucosidase enzymes. Results confirmed the functionality of cookies CGML‐15 y CGML‐10 due to their increased fibre content and biological activity.
Impact of nurse‐led education on the prognosis of heart failure patients: A systematic review and meta‐analysis
Authors: Tian Chun , Zhang Jian , Rong Junmei , Ma Wenhui , Yang Hui 
Published: June 2023

AbstractAimTo perform a meta‐analysis of randomized controlled trials to investigate the effect of nurse‐led education on death, readmission, and quality of life in patients with heart failure.BackgroundThe evidence of the effectiveness of nurse‐led education in heart failure patients from randomized controlled trials is limited, and the results are inconsistent. Therefore, the impact of nurse‐led education remains poorly understood, and more rigorous studies are needed.IntroductionHeart failure is a syndrome associated with high morbidity, mortality, and hospital readmission. Authorities advocate nurse‐led education to raise awareness of disease progression and treatment planning, as this could improve patients' prognosis.MethodsPubMed, Embase, and the Cochrane Library were searched up to May 2022 to retrieve relevant studies. The primary outcomes were readmission rate (all‐cause or HF‐related) and all‐cause mortality. The secondary outcome was quality of life, evaluated by the Minnesota Living with Heart Failure Questionnaire (MLHFQ), EuroQol‐5D (EQ‐5D), and visual analog scale for quality of life.ResultsAlthough there was no significant association between the nursing intervention and all‐cause readmissions [RR (95% CI) = 0.91 (0.79, 1.06), P = 0.231], the nursing intervention decreased HF‐related readmission by 25% [RR (95% CI) = 0.75 (0.58, 0.99), P = 0.039]. The e nursing intervention reduced all‐cause readmission or mortality as a composite endpoint by 13% [RR (95% CI) = 0.87 (0.76, 0.99), P = 0.029]. In the subgroup analysis, we found that home nursing visits reduced HF‐related readmissions [RR (95% CI) = 0.56 (0.37, 0.84), P = 0.005]. In addition, the nursing intervention improved the quality of life in MLHFQ and EQ‐5D [standardized mean differences (SMD) (95% CI) = 3.38 (1.10, 5.66), 7.12 (2.54, 11.71), respectively].DiscussionThe outcome variation between studies may be due to reporting methods, comorbidities, and medication management education. Patient outcomes and quality of life may also vary between different educational approaches. Limitations of this meta‐analysis stem from the incomplete reporting of information from the original studies, the small sample size, and the inclusion of English language literature only.ConclusionNurse‐led education programs significantly impact HF‐related readmission rates, all‐cause readmission, and mortality rates in patients with HF.Implications for nursing practice and nursing policiesThe results suggest stakeholders should allocate resources to develop nurse‐led education programs for HF patients.
Professional engagement: Connecting self‐efficacy to actual turnover among hospital nurses
Authors: Chang Hao‐Yuan , Lee I‐Chen , Tai Shih‐I , Ng Nga Yan , Shiau Wen‐Lung , Yu Wen‐Pin , Cheng T. C. E. , Teng Ching‐I 
Published: June 2023

AbstractAimsTo examine how nurses' self‐efficacy impacts professional engagement (professional opportunities exploration and workplace improvement participation), nurses' turnover intention and further on actual turnover.BackgroundThe problem of nursing shortage has become a common global issue. Nurses' self‐efficacy could reduce nurses' turnover intention. However, whether professional engagement could connect nurses' self‐efficacy and their actual turnover remains unknown.DesignThis study adopts a three‐wave follow‐up design.MethodsThis study uses proportionate random sampling to survey nurses in a large medical centre in Taiwan. Totally, 417 participants were enrolled from December 2021 to January 2022 (first wave) and followed up from February 2022 to March 2022 (second wave). The data of nurses' actual turnover (or not) were traced in May 2022 (third wave). STROBE statement was chosen as the EQUATOR checklist.ResultsSelf‐efficacy was positively linked to outcome expectation, which is positively linked to professional opportunities exploration. Self‐efficacy was positively linked to career interest and workplace improvement participation. Professional engagement was negatively linked to nurses' intention to leave the target hospital, which was positively linked to actual turnover.ConclusionThis study uniquely finds that professional engagement is the key to the mechanism underlying the influence of nurse’ self‐efficacy on their actual turnover.ImpactOur findings impact nursing management that professional engagement is as well important as nurses’ self‐efficacy, with an aim to maintain the professional nursing workforce.Patient or Public ContributionNurses complete the questionnaires, return them to the investigators and permit investigators to check their personnel data.
Abrocitinib efficacy and safety in patients with moderate‐to‐severe atopic dermatitis: Results from phase 3 studies, including the long‐term extension JADE EXTEND study
Authors: Reich Kristian , Silverberg Jonathan I. , Papp Kim A. , Deleuran Mette , Katoh Norito , Strober Bruce , Beck Lisa A. , de Bruin‐Weller Marjolein , Werfel Thomas , Zhang Fan , Biswas Pinaki , DiBonaventura Marco D. , Chan Gary , Johnson Susan , Farooqui Saleem A. , Kerkmann Urs , Clibborn Claire 
Published: June 2023

AbstractBackgroundAbrocitinib improved signs and symptoms of moderate‐to‐severe atopic dermatitis (AD) at 12 or 16 weeks in phase 3 studies with a manageable safety profile. Further understanding of the abrocitinib long‐term efficacy and safety profile is important for its appropriate use in treating chronic AD.ObjectiveTo evaluate the abrocitinib efficacy up to 48 weeks and long‐term safety in patients with moderate‐to‐severe AD.MethodsJADE EXTEND (NCT03422822) is an ongoing, phase 3, long‐term extension study that enrolled patients from previous abrocitinib AD trials. This analysis focusses on patients from the phase 3 JADE MONO‐1 (NCT03349060), JADE MONO‐2 (NCT03575871) and JADE COMPARE (NCT03720470) studies who completed the full treatment period of placebo or abrocitinib (200 mg or 100 mg once daily) and subsequently entered JADE EXTEND. Efficacy endpoints included the proportion of patients achieving skin clearance (Investigator's Global Assessment [IGA] 0/1 [clear/almost clear]; ≥75% improvement in Eczema Area and Severity Index [EASI‐75]) and itch response (Peak Pruritus Numerical Rating Scale [PP‐NRS] severity ≥4‐point improvement). Safety endpoints included treatment‐emergent adverse events (TEAEs), serious TEAEs and TEAEs leading to discontinuation. Data cut‐off: April 22, 2020.ResultsAs of the data cut‐off, ~70% and ~45% of patients received abrocitinib for ≥36 and ≥48 weeks, respectively. Nasopharyngitis, atopic dermatitis, nausea and upper respiratory tract infections were the most frequent TEAEs. Serious TEAEs occurred in 7% and 5% and TEAEs leading to study discontinuation occurred in 9% and 7% of patients receiving abrocitinib 200 mg and 100 mg, respectively. Week 48 efficacy responses with abrocitinib 200 mg and 100 mg were as follows: IGA 0/1 52% and 39%; EASI‐75 82% and 67%, and PP‐NRS severity ≥4‐point improvement 68% and 51%.ConclusionsIn patients with moderate‐to‐severe AD, long‐term abrocitinib treatment resulted in clinically meaningful skin and pruritus improvement. The long‐term safety profile was manageable and consistent with previous reports.
Clinician challenges to evidence‐based prescribing for heart failure and reduced ejection fraction: A qualitative evaluation
Authors: Trinkley Katy E. , Dafoe Ashley , Malone Daniel C. , Allen Larry A. , Huebschmann Amy , Khazanie Prateeti , Lunowa Cali , Matlock Daniel C. , Suresh Krithika , Rosenberg Michael A. , Swat Stanley A. , Sosa Aracely , Morris Megan A. 
Published: June 2023

AbstractBackgroundReasons for suboptimal prescribing for heart failure with reduced ejection fraction (HFrEF) have been identified, but it is unclear if they remain relevant with recent advances in healthcare delivery and technologies. This study aimed to identify and understand current clinician‐perceived challenges to prescribing guideline‐directed HFrEF medications.MethodsWe conducted content analysis methodology, including interviews and member‐checking focus groups with primary care and cardiology clinicians. Interview guides were informed by the Cabana Framework.ResultsWe conducted interviews with 33 clinicians (13 cardiology specialists, 22 physicians) and member checking with 10 of these. We identified four levels of challenges from the clinician perspective. Clinician level challenges included misconceptions about guideline recommendations, clinician assumptions (e.g., drug cost or affordability), and clinical inertia. Patient–clinician level challenges included misalignment of priorities and insufficient communication. Clinician–clinician level challenges were primarily between generalists and specialists, including lack of role clarity, competing priorities of providing focused versus holistic care, and contrasting confidence regarding safety of newer drugs. Policy and system/organisation level challenges included insufficient access to timely/reliable patient data, and unintended care gaps for medications without financially incentivized metrics.ConclusionThis study presents current challenges faced by cardiology and primary care which can be used to strategically design interventions to improve guideline‐directed care for HFrEF. The findings support the persistence of many challenges and also sheds light on new challenges. New challenges identified include conflicting perspectives between generalists and specialists, hesitancy to prescribe newer medications due to safety concerns, and unintended consequences related to value‐based reimbursement metrics for select medications.
Understanding clinical complexity in organ and organizational systems: Challenges local and global
Authors: Samitinjay Aditya , Vaishnavi Karnati , Gongireddy Reethika , Kulakarni Sai Charan , Panuganti Raveen , Vishwanatham Chandana , Manikanta Achuta Kesava , Biswas Rakesh 
Published: June 2023

AbstractIntroductionComplexity in healthcare systems has been arbitrarily defined as tasks or systems ranging from complicated to intractable, with a general view of these not being ‘simple’. Complexity in healthcare systems in first‐world countries has been well elucidated, however, data from third‐world countries is still scant.Materials and MethodsWe present four cases each from three different organ systems—chronic kidney disease, alcohol use disorder, and heart failure—in the backdrop of our healthcare organization. We present our analysis of the complexities faced clinically and, in our local healthcare system which led to these events.ResultsAnalysis of these cases showed that patients with chronic kidney disease had vertebral–spinal pathologies due to poor infection control measures during haemodialysis. All these patients were young with a long history of secondary hypertension. In patients with alcohol use disorder, a common theme of how government regulations and peer pressure promote alcohol use is analysed. In the four patients with unexplained heart failure, vascular health is viewed as a fractal dimension and the various factors affecting vascular health are elaborated.ConclusionComplexities exist clinically in making a diagnosis, and organizationally, in the variables and nodes dictating patient outcomes. Clinical complexities cannot be simplified but have to be navigated in an optimized way to improve clinical outcomes.
Impact of nanoscale coating of stainless steel on Salmonella Enteritidis and Escherichia coli
Authors: Schumann‐Muck Felicitas Maria , Hillig Nadja , Braun Peggy G. , Griebel Jan , Koethe Martin 
Published: June 2023

AbstractCross‐contamination in the poultry slaughtering process can lead to thespread of zoonotic bacteria like Salmonellaenterica. Surfaces of equiptment may facilitate contamination of carcasses due to bacterial adherence and transfer. In this study, attachment, proliferation, and detachment of Salmonella Enteritidis and Escherichia coli were comparatively investigated on uncoated and silica‐coated stainless‐steel surfaces. The conditions occurring in the slaughtering workflow were imitated on laboratory scale, for example, spilling of contaminated liquid onto equipment surfaces, pressing or sliding of carcasses against surfaces during the slaughtering procedure, and cleaning of contaminated stainless‐steel surfaces with water or detergent. Growth on stainless‐steel surfaces was measured for 8 h. The applied silica coating led to a partly higher repelling effect without impact on proliferation for the target organisms on stainless steel. Further development of the coating and daption to the exact circumstances as well as more extending testing under real conditions would be the next steps.
Is meal order timing and flexibility key to improving patient satisfaction with hospital foodservice?
Authors: Barsha Laura , McCray Sally , Maunder Kirsty 
Published: June 2023

AbstractAimThe aim of this study was to retrospectively evaluate and compare patient foodservice (FS) satisfaction using a validated tool and consistent methodology in an acute health service for four different FS models as the organisation transitioned through traditional model (TM), choice at point of service (CaPOS), bedside menu ordering systems (BMOS) and room service (RS) from 2013 to 2016.MethodsPatient satisfaction data were collected using the Acute Care Hospital Foodservice Patient Satisfaction Questionnaire. For the purposes of this study, patients' rating of their overall experience with FS (very good, good, okay, poor or very poor) was compared for each site and model.ResultsSatisfaction was significantly higher in the CaPOS and RS models compared with TM. BMOS, although somewhat higher, was not shown to be significantly higher than TM. The RS model was significantly higher than BMOS, but there was no significant difference observed between RS and CaPOS.ConclusionFS models that support patient flexibility and meal ordering closer to the meal delivery time (as seen with RS and CaPOS) show higher patient satisfaction among hospital patients. It is recommended that sites consistently opt to include patient satisfaction as part of routine auditing. This would enable clear conclusions to be drawn regarding best practice FS models, based on specific and individual hospital requirements.
The role of Australian civil society organisations in food system governance: Opportunities for collaboration in dietetics practice
Authors: Carrad Amy , Smits Rebecca , Charlton Karen , Rose Nick , Reeve Belinda 
Published: June 2023

AbstractBackgroundCivil society organisations (CSOs) are increasingly participating in food system governance in ways that challenge the dominant industrialised profit‐driven system.MethodsAn online survey of Australian CSOs that self‐identified as being involved in food system governance was conducted to identify their objectives and activities and the enablers of, and barriers to, their participation in food system governance. Respondents were nongovernment organisations/registered charities, social enterprises, businesses and collaborative research initiatives involved in food system governance in Australia (n = 43).ResultsOrganisations undertook activities across all dimensions of the food system (food growing/production, distribution, sale, marketing, access and consumption) and had diverse goals related to health, sustainability and social and economic development. They engaged in food system governance via activities such as advocacy and lobbying for policy and legislative change and guiding policy development. Key enablers of this engagement included funding, internal capacity, external supports and collaborations, and inclusive consultation processes and, when not present, were considered barriers.ConclusionsCSOs play an important role in food system governance in Australia, including by influencing policy outcomes, contributing to more inclusive and democratic forms of governance and leading community‐based food system policies. For CSOs to play a more central role, provision of longer‐term funding; creation of dedicated food and nutrition policies at local, state and federal government levels; and governance processes that are inclusive, accessible and minimise power differentials are required. This study's findings can be used to identify many opportunities for dietitians to engage with CSOs in education, research and advocacy roles for food system transformation.
Evaluation of the effects of 10% and 30% gluconolactone chemical peel on sebum, pH, and TEWL
Authors: Jarząbek‐Perz Sylwia , Dziedzic Marta , Rotsztejn Helena , Kołodziejczak Anna 
Published: June 2023

AbstractBackgroundGluconolactone (GLA) exhibits antioxidant and moisturizing effects. It also presents soothing effects, protects elastin fibers from UV‐induced degradation, and improves the function of the skin barrier.AimsEvaluation of skin parameters such as pH, transepidermal water loss (TEWL), sebum levels before, during, and after a series of applications of 10% and 30% GLA chemical peel in a split‐face model.Materials and MethodsThe study involved 16 female subjects. Three split‐face procedures were performed using two concentrations of GLA solution applied on two sides of the face. The skin parameters were measured before treatments and 7 days after the last procedure at four measurement sites on either side of the face, that is, on the forehead, around the eye, on the cheek, and on the nose wing.ResultsMeasurement of sebum demonstrated some statistically significant changes between sebum levels in the cheeks after a series of treatments. The pH measurement showed that the pH value was reduced after each treatment at all measurement points. The level of TEWL after treatments was significantly lower around the eyes, on the left forehead, and on the right cheek. There were no significant differences between the use of different concentrations of the GLA solution.ConclusionsThe results of the study show that GLA has a significant influence on lowering skin pH and TEWL. GLA also has seboregulatory properties.
Religious Ethics and Public Policy: On Doing Public Bioethics
Authors: Childress James F. 
Published: June 2023

ABSTRACTIn response to theJournal of Religious Ethics(JRE) editors' request for reflections on “how religious ethicists have interacted with, and ought to interact with, public policy decision makers,” this essay focuses on doing religious ethics in the context of doing public bioethics, especially through participating in public bioethics bodies (PBBs) established to provide advice to public policymakers in what might be called “mediated advocacy.” Drawing heavily on the author's experience as a member of and a consultant to several PBBs, it features case studies of PBBs deliberating about and recommending public policies to address the scarcity of postmortem organs for transplantation, the equitable allocation of COVID‐19 vaccine, cloning humans, and human embryonic stem cell research.
Anti‐Bullying Interventions With an Emphasis on Bystanders: A Scoping Review
Authors: Bezerra Luiza Luana de Araújo Lira , Alves Dayse Lorrane Gonçalves , Nunes Bruna Rodrigues , Stelko‐Pereira Ana Carina , Florêncio Raquel Sampaio , Gomes Ilvana Lima Verde 
Published: June 2023

ABSTRACTBACKGROUNDBystanders' role in bullying situations is important, and may exacerbate or minimize the problem. Thus, this article aims to identify the characteristics of anti‐bullying programs with an emphasis on bystanders.METHODSThis is a scoping review. We included studies that addressed interventions with an emphasis on bystanders, carried out with school children and adolescents, aimed at reducing bullying/cyberbullying and/or increasing defending behavior. Fifteen portals/databases were searched. The selection and extraction processes were carried out through the blind review strategy. The synthesis took place descriptively.RESULTSWe found 12 interventions. The most investigated were KiVa (n = 9), STAC (n = 3), and Curriculum‐Based Anti‐Bullying (n = 2).CONCLUSIONSThere are few anti‐bullying programs with an emphasis on bystanders, and the majority are universal programs with strategies applied by teachers, giving little attention to parents. Moreover, most of these programs lack a broader mix of anti‐bullying strategies. Therefore, we suggest developing anti‐bullying programs with multiple components that contain universal, selective, and indicated strategies.