bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of intrathecal therapeutic injections in spinal muscular atrophy patients via a percutaneous transsacral hiatus route: An initial neuroimaging morphometric study
Authors: Dhawan Siddhant Suri , Trinh Austin , Massoud Tarik F. 
Published: December 2022

AbstractIntroduction/AimsStandard fluoroscopic lumbar puncture (LP) can be impossible in patients with severe spinal deformities from spinal muscular atrophy (SMA) who require intrathecal nusinersen therapy. There usually exists a straight trajectory in the lower sacral canal (SC) that could allow image‐guided percutaneous transsacral hiatus puncture of the lumbosacral dural sac. In this study we determine whether sacra are comparatively straighter in SMA patients (SMAps) vs healthy controls (HCs), which may facilitate unhindered transsacral hiatus spinal needle insertion for intrathecal nusinersen therapy.MethodsWe retrospectively analyzed lumbosacral spine computed tomograms (CTs) or CT‐myelogram images of 38 SMAps and age‐ and sex‐matched HCs. We digitally measured ventrodorsal sacral curvatures, SC surface areas, dural sac termination levels, and distances from sacral hiatus to the most caudad aspects of dural sacs (“needle distance”).ResultsMean ages of HCs and SMAps were 32.7 and 31.7 years, respectively, with dural sacs terminating at similar levels. Mean values for morphometrics were: (a) midsagittal SC surface area for HCs = 701.2 mm2, and for SMAps = 601.5 mm2 (not statistically significant [ns]); (b) using a “line method,” sacral curvature for HCs = 61.9°, and SMAp = 35.7° (P = .0009), and was similar when using an “angle summation method”; (c) width of sacral hiatus for HCs = 14.9 mm, and SMAps = 15.0 mm (ns); and (d) “needle distance” for HCs = 54.7 mm, and SMAps = 49.9 mm (ns).DiscussionSMAps have significantly straighter sacra compared with HCs, which theoretically renders them more amenable to percutaneous transsacral hiatus puncture of the dural sac.
A hybrid strategy blending primal‐dual interior point and return mapping methods for a class of hypoelastic‐plastic models with memory surface
Authors: Shintaku Yuichi , Nakamura Fumitoshi , Terada Kenjiro 
Published: December 2022

AbstractBy blending the primal‐dual interior point method (PDIPM) and the return mapping algorithm, we propose a hybrid strategy of implicit stress update for a class of hypoelastic‐plastic models with the hardening rule whose evolution is restricted by the memory surface. The inequality constraint relevant to the memory surface is replaced by the equality constraint by the introduction of a slack variable, and the duality gap is gradually reduced by using path‐following method. First, we formulate an optimization problem corresponding to the principle of maximum plastic dissipation for the standard von‐Mises plasticity with isotropic and kinematic hardening rules and its variant for the model with the memory surface. Next, after function forms employed for the elastic‐plastic model are specified, the PDIPM to realize an implicit stress update is briefly reviewed and then applied to the model involving the memory surface to replace the relevant inequality constraint by the equality constraint by the introduction of a slack variable. Then, we present a hybrid scheme that combines the standard return mapping algorithm with the PDIPM. The numerical accuracy of the proposed stress update algorithm for the conventional elastic‐plastic model is verified in comparison with the standard return mapping algorithm using iso‐error map. Also, targeting a notched round steel bar under cyclic loading with three different amplitudes, we demonstrate the performance for the stress update using the elastic‐plastic model with the memory surface. Finally, the capability of the proposed algorithm is proven through a typical real‐life example such that a steel bridge is subjected to earthquake for which the residual load carrying capacity must be estimated.
Predictors of mortality and ICU requirement in hospitalized COVID‐19 patients with diabetes: A multicentre study
Authors: Asaduzzaman Md , Romel Bhuia Mohammad , Zabed Jillul Bari Mohammad , Nazmul Alam Zhm , Rahman Khalidur , Hossain Enayet , Alam Munsi Mohammad Jahangir 
Published: December 2022

AbstractAimThis study aimed to identify the predictors of mortality and ICU requirements in hospitalized COVID‐19 Patients with Diabetes.DesignCross‐sectional study.MethodsIt was a retrospective study of patients hospitalized with COVID‐19 infection from October 2020–February 2021 in four hospitals in Sylhet, Bangladesh. Logistic regression analysis was applied to explore the predictors of ICU requirement and in‐hospital mortality.ResultsIn the whole cohort (n = 500), 11% of patients died and 24% of patients required intensive care unit (ICU) support. Non‐survivors had significantly higher prevalence of lymphopenia, thrombocytopenia and leukocytosis. Significant predictors of in‐hospital mortality were older age, neutrophil count, platelet count and admission peripheral capillary oxygen saturation (SpO2). Older age, ischemic heart disease, WBC count, D‐dimer and admission SpO2 were identified as significant predictors for ICU requirement.Patient or Public ContributionNo.
Factors affecting the length of stay in the emergency department for critically Ill patients transferred to regional emergency medical center
Authors: Lee Hyungbok , Lee Sangrim , Kim Hyeoneui 
Published: December 2022

AbstractAimTo identify the factors affecting Emergency Department Length of Stay for transferred critically ill patients.BackgroundThe Length of Stay of the transferred patients is an important indicator of Emergency Department service quality; thus, understanding the factors affecting the Emergency Department Length of Stay of transferred critically ill patients is essential.MethodsUsing the electronic medical records of 968 transferred critically ill Emergency Department patients of a tertiary hospital in Korea, prediction models for Emergency Department Length of Stay were built using various machine learning algorithms.ResultsThe logistic regression (AUROC 0.85) models showed the best performance, followed by random forest (AUROC 0.83) and Naive Bayes (AUROC 0.83). The logistic regression model indicated that fewer consultations, the highest acuity level, need for an emergency operation or angiography, need for ICU admission, severe emergency disease and fewer diagnoses were the statistically significant predictors for Emergency Department Length of Stay of 6 h or less.ConclusionsThe transferred critically ill patients analysed in this study who required immediate or specialized care tended to receive needed care on time at the study site.Implications for Nursing ManagementUnderstanding the factors affecting the Emergency Department Length of Stay of transferred critically ill patients is crucial for developing strategies to manage the nursing resource of Emergency Department successfully.
Embodied labors during the state formation of Egypt and Nubia (ca. 4800–1750 BCE): Elucidating transformations in behavioral patterns with entheseal changes
Authors: Carballo‐Pérez Jared , Schrader Sarah A. 
Published: December 2022

AbstractThroughout Egypt and Nubia's state formation periods (4400–1750 BCE), broad transformations impacted Nile Valley communities, which experienced agricultural consolidation, sedentarization, and more complex social organization. The current study examines the various patterns and levels of physical activity in the skeletal remains of 259 predynastic and early dynastic individuals from Nubia (Northern Dongola Reach) and Egypt (el‐Badari, Naqada, el‐Ballas, and Hu). Using entheseal changes in the upper and lower limbs and non‐parametric tests, we have observed changes in behavior patterns between the fifth and second millennia BCE in the Nile Valley. These transformations include an increased impact on the evolution of physical activity and possibly specialized occupations in the Old Kingdom. In this regard, we discovered differences in activity based on the type of burial and the tasks performed by females compared with males. Furthermore, we found additional evidence to support the hypothesis that the Nubian state of Kerma was based on a highly mobile pastoral way of life.
Substituting sedentary time with sleep or physical activity and subsequent weight‐loss maintenance
Authors: Larsen Sofus C. , O'Driscoll Ruairi , Horgan Graham , Mikkelsen Marie‐Louise K. , Specht Ina O. , Rohde Jeanett F. , Turicchi Jake , Santos Inês , Encantado Jorge , Duarte Cristiana , Ward Leigh C. , Palmeira Antonio L. , Stubbs R. James , Heitmann Berit L. 
Published: December 2022

AbstractObjectiveIn this study, the associations between the substitution of sedentary time with sleep or physical activity at different intensities and subsequent weight‐loss maintenance were examined.MethodsThis prospective study included 1152 adults from the NoHoW trial who had achieved a successful weight loss of ≥5% during the 12 months prior to baseline and had BMI ≥25 kg/m2 before losing weight. Physical activity and sleep were objectively measured during a 14‐day period at baseline. Change in body weight was included as the primary outcome. Secondary outcomes were changes in body fat percentage and waist circumference. Cardiometabolic variables were included as exploratory outcomes.ResultsUsing isotemporal substitution models, no associations were found between activity substitutions and changes in body weight or waist circumference. However, the substitution of sedentary behavior with moderate‐to‐vigorous physical activity was associated with a decrease in body fat percentage during the first 6 months of the trial (−0.33% per 30 minutes higher moderate‐to‐vigorous physical activity [95% CI: −0.60% to −0.07%], p = 0.013).ConclusionsSedentary behavior had little or no influence on subsequent weight‐loss maintenance, but during the early stages of a weight‐loss maintenance program, substituting sedentary behavior with moderate‐to‐vigorous physical activity may prevent a gain in body fat percentage.
SSA‐optimized cascade optimal‐PIDN controller for multi‐area power system with RFB under deregulated environment
Authors: Rangi Sandeep , Jain Sheilza , Arya Yogendra 
Published: December 2022

AbstractIn today's rapidly evolving interconnected electric power system network, ancillary service such as automatic generation control (AGC) plays a critical and important role in safeguarding the system's power supply quality by establishing an equilibrium between generation and load demanded plus losses. A power system with a robust and smart AGC strategy is obligatory for better power quality and system security. Cascade control schemes cope up better with nonlinearity by tuning the gain of controller of power system amid continuous load changing. Therefore, in this article, a supplementary control approach that is, cascade optimal controller‐proportional integral with derivative filter (COC‐PIDN) is suggested for AGC performance advancement of the power systems under deregulated environment. The OC designed consuming full state feedback control approach acts as master controller and PIDN plays the role of slave controller. The nature inspired salp swarm algorithm is employed to adjust the PIDN parameters. Initially, the efficacy of the COC‐PIDN control‐method is explored on a two‐area restructured reheat thermal system and then to validate its excellence and extensibility, the study is protracted to restructured two‐area thermal‐hydro system. Extensive analysis of the findings establishes that the dynamic performance of the COC‐PIDN controller is more valuable than the OC and COC‐PID approaches. The results of COC‐PIDN get further improved in presence of redox flow battery. Finally, the sensitivity analysis as well the acquired results with the COC‐PIDN controller with system nonlinearities demonstrate its robustness.
Connecting DSM‐5 and ICD‐11 trait domains with schema therapy and dialectical behavior therapy constructs
Authors: Tracy Mikaela , Sharpe Louise , Bach Bo , Tiliopoulos Niko 
Published: December 2022

AbstractThe DSM‐5 Section III alternative model of personality disorder (AMPD) and the International Classification of Diseases – 11th Edition's (ICD‐11) personality disorder classification allow clinicians to identify individual trait domains in which people score highly. However, how these domains relate to constructs associated with efficacious treatment approaches is unclear. The current study aimed to determine whether constructs from two evidence‐based treatments (schema therapy [ST] and dialectical behavior therapy [DBT]) were associated with maladaptive personality traits in a way consistent with underlying theories. We examined associations between ST constructs, DBT skill use and maladaptive coping styles, and personality traits in a sample of 525 adults. Bivariate intercorrelations and a series of multiple regression analyses were conducted to investigate the associations. As hypothesized, maladaptive coping was strongly associated with all trait domains. Surprisingly, poor DBT‐skill use was only associated with negative affectivity, detachment, and disinhibition trait domains. Specific schema domains were associated with each personality trait domain, supporting trait domain‐schema domain specificity. The current study highlights the potential clinical utility of the AMPD and ICD‐11 trait models and ultimately contributes to the dearth of evidence on their likely usefulness for treatment selection, planning, and applications.
Amorphous silicon carbonitride (a‐SiCN) thin film coatings by remote plasma chemical vapor deposition using organosilicon precursor: Effect of substrate temperature
Authors: Wrobel Aleksander M. , Uznanski Pawel 
Published: December 2022

AbstractThe study on amorphous hydrogenated silicon carbonitride (a‐SiCN) thin film coatings produced by remote plasma chemical vapor deposition from 1,1,3,3‐tetramethyldisilazane as single‐source compound is reviewed. The RP was generated using three extreme compositions of the H2 + N2 upstream‐gas mixture with a different nitrogen content CN2 = [N2]/([H2] + [N2]). The films were deposited using plasma generated from with pure hydrogen (CN2 = 0), pure nitrogen (CN2 = 1), and a mixture of H2 + N2 with a nitrogen content of CN2 = 0.88, corresponding to the maxima present in the NH hydronitrene emission intensity curve and film deposition yield curve. The films deposited at different substrate temperatures TS varied in the range of 30–400°C were characterized in terms of their deposition rate and yield, chemical structure, surface roughness, density, refractive index, hardness, elasticity, resistance to wear, and friction coefficient. The relationships of the structure and properties of the films controlled by the substrate temperature were determined and discussed. In view of their good mechanical properties, a‐SiCN films produced using hydrogen as plasma feeding gas appear to be very excellent coatings for improving surface properties of engineering materials and for many other advanced technological applications.
Combination with vorinostat enhances the antitumor activity of cisplatin in castration‐resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH
Authors: Chang Taihao , Lian Zhenpeng , Ma Shenfei , Liang Zhengxin , Ma Xudong , Wen Xiaodong , Wang Yanming , Liu Ranlu 
Published: December 2022

AbstractBackgroundLike DNA methylation, histone modifications are considered important processes for epigenetic alterations in gene function, and abnormally high expression of histone deacetylases (HDACs) plays a key role in many human diseases. In addition to regulating the acetylation levels of histone and non‐histone proteins and gene transcription, HDAC inhibitors as antitumor drugs can also affect the DNA damage repair (DDR) pathway in tumor cells. Prostate cancer (PCa) is one of the most heritable malignancies in which DDR pathway defects can be detected in a considerable proportion of cases. Such defects are more prevalent in castration‐resistant prostate cancer (CRPC) and are highly enriched in metastatic lesions. There is currently evidence that DDR pathway‐deficient PCa is associated with high‐risk biological behaviors and response sensitivity to platinum‐based chemotherapy. Platinum‐based drugs have been used in multiple clinical trials as monotherapy or in combination with other chemotherapeutic agents for the treatment of CRPC.MethodsThis study evaluated the combined anticancer effect of (cisplatin) CDDP and the HDAC inhibitors vorinostat (SAHA) on three androgen‐dependent cell lines PC‐3, DU‐145, and C4‐2B in vitro. The efficacy and safety of SAHA combined with CDDP in the treatment of CRPC were further verified through animal experiments.ResultsThe combination of the two drugs increases cytotoxic effects by increasing DNA damage. Our results showed that the SAHA could not only reduce the expression of homologous recombinant repair proteins BRCA2, BRCA1, PARP1, and RAD51, but also decrease enzymes that Reduce the key enzymes of GSH biosynthesis, GSS and GCLC, and GSTP1 which can catalyze the binding of GSH to cisplatin. The intracellular GSH level also decreased with the increase of SAHA concentration, at the same time, the content of intracellular Pt element.ConclusionThe combination of CDDP and SAHA can produce synergistic anticancer effects in androgen‐independent PCa cells in vitro and in vivo. Our results open up a new avenue for the effective treatment of CRPC. To optimize the chemotherapy regimen for patients with advanced PCa, it is necessary to further study the molecular mechanism of platinum drugs, HDAC inhibitors, and their combined action.
Dihydroartemisinin broke the tumor immunosuppressive microenvironment by inhibiting YAP1 expression to enhance anti‐PD‐1 efficacy
Authors: Peng Qing , Li Shenghao , Shi Xinli , Guo Yinglin , Hao Liyuan , Zhang Zhiqin , Ji Jingmin , Zhao Yanmeng , Li Caige , Xue Yu , Liu Yiwei 
Published: December 2022

AbstractThe efficacy of anti‐PD‐1 therapy is not as expected in hepatocellular carcinoma (HCC). YAP1 was overexpressed and activated in HCC. The mechanism of YAP1 in HCC immune escape is unclear. Anti‐PD‐1 treatment increased YAP1 expression in liver tumor cells, and exhausted CD4+ and CD8+ T cells in the blood and spleen of liver tumor mice. YAP1 knockdown suppressed PD‐L1 expression, which was involved in JAK1/STAT1, 3 pathways. Moreover, Yap1 knockout elevated CD4+ and CD8+ T cells in liver tumor niche. Consistently, verteporfin, YAP1 inhibitor, decreased TGF‐β and IFN‐γ in liver tumor niche and exhausted CD8+ T cell in the spleen. DHA suppressed YAP1 expression and break immune evasion in liver tumor niche, characterized by decreased PD‐L1 in liver tumor cells and increased CD8+ T cell infiltration. Furthermore, DHA combined with anti‐PD‐1 treatment promoted CD4+ T cell infiltration in the spleen and CD8+ T cell in tumor tissues of mice. In summary, YAP1 knockdown in liver tumor cells suppressed PD‐L1 expression and recruited cytotoxic T lymphocytes (CTLs), leading to break immune evasion in tumor niche. Mechanistically, YAP1 knockdown suppressed PD‐L1 expression, which was involved in JAK1/STAT1, 3 pathways. Finally, DHA inhibited YAP1 expression, which not only inhibited liver tumor proliferation but also break the immunosuppressive niche in liver tumor tissues and improve the effect of anti‐PD‐1 therapy.
Constrained control for systems on matrix Lie groups with uncertainties
Authors: Shi Chuanbeibei , Yu Yushu , Ma Yuwei , Chang Dong Eui 
Published: December 2022

AbstractIn this paper, the constrained control of systems evolving on matrix Lie groups with uncertainties is considered. The proposed methodology is composed of a nominal Model Predictive Control (MPC), and a feedback controller. The previous work on the control of systems on manifolds is applied to design the nominal MPC, which generates the nominal trajectory. In the nominal MPC, the state and input constraints on the Lie group are transformed into the constraints on the Euclidean space. While to deal with uncertainties, the feedback control used to track the nominal trajectory is designed directly on the Lie group. The tracking error in the feedback control is proved to be bounded in invariant sets, which are further used to revise the constraints in nominal MPC. We prove that the input‐to‐state stability of the entire system under the proposed control methodology with respect to the disturbances can be achieved. The proposed methodology is applied to the constrained attitude control of rigid bodies with uncertainties. In the application example, the detailed mathematical proof and the comparative numerical simulation are presented to demonstrate the feasibility of the proposed methodology.
Environmental governance, local government competition and industrial green transformation: Evidence from China's sustainable development practice
Authors: Yang Luxin , Liu Yucheng , Deng Huihui 
Published: December 2022

AbstractThe rapid development of China's economy has also led to serious environmental problems, which have seriously restricted China's sustainable development. To this end, the Chinese government has continued to explore environmental governance. So, can environmental governance policies promote industrial green transformation, so as to achieve the goal of sustainable development? Will environmental policy competition among local governments have an impact on them? These issues are the focus of this article. Based on the provincial panel data of China from 2006 to 2021, this article empirically analyzes the relationship between environmental governance, local government competition, and industrial green transformation. The results found that there was a “U” type nonlinear relationship between environmental governance and industrial green transformation. On the whole, most regions of China are still in the development stage where environmental governance is not conducive to industrial green transformation. There is competition for environmental governance policies among local governments in China, and the characteristics of “race to the bottom” are more significant. In the East developed areas, there is a more significant “yardstick competition” game state. In the Midwest undeveloped areas, it is manifested as competition for resources by deregulation of the environment, thereby promoting short‐term economic growth. In addition, local protection behaviors negatively regulate the impact of environmental governance on industrial green transformation, that is, inhibiting local industrial green transformation by causing labor market mismatch. This study can provide valuable insights for policymakers aiming to adopt measures to achieve the sustainable development of the economy and environment.