bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-time insight into the multistage mechanism of nanoparticle exsolution from a perovskite host surface
Authors: Calì Eleonora , Thomas Melonie P. , Vasudevan Rama , Wu Ji , Gavalda-Diaz Oriol , Marquardt Katharina , Saiz Eduardo , Neagu Dragos , Unocic Raymond R. , Parker Stephen C. , Guiton Beth S. , Payne David J. 
Published: March 2023

AbstractIn exsolution, nanoparticles form by emerging from oxide hosts by application of redox driving forces, leading to transformative advances in stability, activity, and efficiency over deposition techniques, and resulting in a wide range of new opportunities for catalytic, energy and net-zero-related technologies. However, the mechanism of exsolved nanoparticle nucleation and perovskite structural evolution, has, to date, remained unclear. Herein, we shed light on this elusive process by following in real time Ir nanoparticle emergence from a SrTiO3 host oxide lattice, using in situ high-resolution electron microscopy in combination with computational simulations and machine learning analytics. We show that nucleation occurs via atom clustering, in tandem with host evolution, revealing the participation of surface defects and host lattice restructuring in trapping Ir atoms to initiate nanoparticle formation and growth. These insights provide a theoretical platform and practical recommendations to further the development of highly functional and broadly applicable exsolvable materials.
Increasing extreme melt in northeast Greenland linked to foehn winds and atmospheric rivers
Authors: Mattingly Kyle S. , Turton Jenny V. , Wille Jonathan D. , Noël Brice , Fettweis Xavier , Rennermalm Åsa K. , Mote Thomas L. 
Published: March 2023

AbstractThe Greenland Ice Sheet has been losing mass at an increased rate in recent decades. In northeast Greenland, increasing surface melt has accompanied speed-ups in the outlet glaciers of the Northeast Greenland Ice Stream, which contain over one meter of sea level rise potential. Here we show that the most intense northeast Greenland melt events are driven by atmospheric rivers (ARs) affecting northwest Greenland that induce foehn winds in the northeast. Near low-elevation outlet glaciers, 80–100% of extreme (> 99th percentile) melt occurs during foehn conditions and 50–75% during ARs. These events have become more frequent during the twenty-first century, with 5–10% of total northeast Greenland melt in several recent summers occurring during the ~1% of times with strong AR and foehn conditions. We conclude that the combined AR-foehn influence on northeast Greenland extreme melt will likely continue to grow as regional atmospheric moisture content increases with climate warming.
Unexpected genetic and microbial diversity for arsenic cycling in deep sea cold seep sediments
Authors: Zhang Chuwen , Liu Xinyue , Shi Ling-Dong , Li Jiwei , Xiao Xi , Shao Zongze , Dong Xiyang 
Published: March 2023

AbstractCold seeps, where cold hydrocarbon-rich fluid escapes from the seafloor, show strong enrichment of toxic metalloid arsenic (As). The toxicity and mobility of As can be greatly altered by microbial processes that play an important role in global As biogeochemical cycling. However, a global overview of genes and microbes involved in As transformation at seeps remains to be fully unveiled. Using 87 sediment metagenomes and 33 metatranscriptomes derived from 13 globally distributed cold seeps, we show that As detoxification genes (arsM,arsP,arsC1/arsC2,acr3) were prevalent at seeps and more phylogenetically diverse than previously expected. Asgardarchaeota and a variety of unidentified bacterial phyla (e.g. 4484-113, AABM5-125-24 and RBG-13-66-14) may also function as the key players in As transformation. The abundances of As cycling genes and the compositions of As-associated microbiome shifted across different sediment depths or types of cold seep. The energy-conserving arsenate reduction or arsenite oxidation could impact biogeochemical cycling of carbon and nitrogen, via supporting carbon fixation, hydrocarbon degradation and nitrogen fixation. Overall, this study provides a comprehensive overview of As cycling genes and microbes at As-enriched cold seeps, laying a solid foundation for further studies of As cycling in deep sea microbiome at the enzymatic and processual levels.
Two-dimensional ferroelectrics from high throughput computational screening
Authors: Kruse Mads , Petralanda Urko , Gjerding Morten N. , Jacobsen Karsten W. , Thygesen Kristian S. , Olsen Thomas 
Published: March 2023

AbstractWe report a high throughput computational search for two-dimensional ferroelectric materials. The starting point is 252 pyroelectric materials from the computational 2D materials database (C2DB) and from these we identify 63 ferroelectrics. In particular we find 49 materials with in-plane polarization, 8 materials with out-of-plane polarization and 6 materials with coupled in-plane and out-of-plane polarization. Most of the known 2D ferroelectrics are recovered by the screening and the far majority of the predicted ferroelectrics are known as bulk van der Waals bonded compounds, which makes them accessible by direct exfoliation. For roughly 25% of the materials we find a metastable state in the non-polar structure, which may imply a first order transition to the polar phase. Finally, we list the magnetic pyroelectrics extracted from the C2DB and focus on the case of VAgP2Se6, which exhibits a three-state switchable polarization vector that is strongly coupled to the magnetic excitation spectrum.
Extracurricular music and visual arts activities are related to academic performance improvement in school-aged children
Authors: Ishiguro Chiaki , Ishihara Toru , Morita Noriteru 
Published: March 2023

AbstractThe present longitudinal study examined whether extracurricular activities in the arts and corresponding scores in art classes have a positive association with general academic performance. Data were collected from 488 seventh-grade children (259 boys and 229 girls) for over two years. Information regarding their participation in extracurricular activities in music and visual arts, grade points in general academic performance (i.e., Japanese, Social Studies, Mathematics, Science, and English), music, and arts were obtained at the end of the seventh and ninth grades. Structural equation modeling revealed that participation in extracurricular activities in both music and visual arts was positively associated with improvements in general academic performance from the seventh and ninth grades, and these associations were related to changes in music and visual arts scores. This finding suggests that arts education can contribute to improving general academic performance; however, the current study shows correlational relationships. Future research should examine the causal relationship between art involvement and academic performance by controlling for other factors (e.g., IQ, motivation, etc.).
Resonant inelastic x-ray scattering data for Ruddlesden-Popper and reduced Ruddlesden-Popper nickelates
Authors: Fabbris G. , Meyers D. , Shen Y. , Bisogni V. , Zhang J. , Mitchell J. F. , Norman M. R. , Johnston S. , Feng J. , Chiuzbăian G. S. , Nicolaou A. , Jaouen N. , Dean M. P. M. 
Published: March 2023

AbstractRuddlesden-Popper and reduced Ruddlesden-Popper nickelates are intriguing candidates for mimicking the properties of high-temperature superconducting cuprates. The degree of similarity between these nickelates and cuprates has been the subject of considerable debate. Resonant inelastic x-ray scattering (RIXS) has played an important role in exploring their electronic and magnetic excitations, but these efforts have been stymied by inconsistencies between different samples and the lack of publicly available data for detailed comparison. To address this issue, we present open RIXS data on La4Ni3O10and La4Ni3O8.
Sarcopenia as a potential risk factor for senile blepharoptosis: Nationwide Surveys (KNHANES 2008–2011)
Authors: Byeon Hyeong Ju , Kim Yong Joon , Yoon Jin Sook , Ko JaeSang 
Published: March 2023

AbstractAs the world’s population is aging, sarcopenia is recognized as essential to assess people’s lifelong condition and do appropriate early intervention. Senile blepharoptosis is also a problem in old age deteriorating visual function and causing a cosmetic decline. We investigated the association between sarcopenia and the prevalence of senile blepharoptosis, using a nationwide representative survey in Korea. A total of 11,533 participants were recruited. We used the body mass index (BMI)- adjusted appendicular skeletal muscle (ASM) definition as the muscle mass index (MMI, ASM [kg] divided by BMI [kg/m2]). The association between blepharoptosis prevalence and MMI was analyzed using multivariate logistic regression. Sarcopenia, defined as the lowest MMI quintile group in both men and women, was also associated with the prevalence of blepharoptosis (ORs 1.92, 95% CI 1.17–2.16; p < 0.001). These associations remained statistically significant after adjusting for various factors related to blepharoptosis using multivariate analysis (ORs 1.18, 95% CI 1.04–1.34; p = 0.012). Moreover, MMI was found to have a proportional relationship with eyelid lifting force (levator function), which is closely related to the occurrence and severity of ptosis. Sarcopenia is related to the prevalence of senile blepharoptosis, and patients with lower MMI were more likely to have blepharoptosis. These results suggest that sarcopenia can affect visual function and aesthetics.
Abnormalities in intron retention characterize patients with systemic lupus erythematosus
Authors: Sun Xiaoqian , Liu Zhichao , Li Zongzhu , Zeng Zhouhao , Peng Weiqun , Zhu Jun , Zhao Joel , Zhu Chenghao , Zeng Chen , Stearrett Nathaniel , Crandall Keith A. , Bachali Prathyusha , Grammer Amrie C. , Lipsky Peter E. 
Published: March 2023

AbstractRegulation of intron retention (IR), a form of alternative splicing, is a newly recognized checkpoint in gene expression. Since there are numerous abnormalities in gene expression in the prototypic autoimmune disease systemic lupus erythematosus (SLE), we sought to determine whether IR was intact in patients with this disease. We, therefore, studied global gene expression and IR patterns of lymphocytes in SLE patients. We analyzed RNA-seq data from peripheral blood T cell samples from 14 patients suffering from systemic lupus erythematosus (SLE) and 4 healthy controls and a second, independent data set of RNA-seq data from B cells from16 SLE patients and 4 healthy controls. We identified intron retention levels from 26,372 well annotated genes as well as differential gene expression and tested for differences between cases and controls using unbiased hierarchical clustering and principal component analysis. We followed with gene-disease enrichment analysis and gene-ontology enrichment analysis. Finally, we then tested for significant differences in intron retention between cases and controls both globally and with respect to specific genes. Overall decreased IR was found in T cells from one cohort and B cells from another cohort of patients with SLE and was associated with increased expression of numerous genes, including those encoding spliceosome components. Different introns within the same gene displayed both up- and down-regulated retention profiles indicating a complex regulatory mechanism. These results indicate that decreased IR in immune cells is characteristic of patients with active SLE and may contribute to the abnormal expression of specific genes in this autoimmune disease.
Retinal vessel geometry in patients with idiopathic epiretinal membrane
Authors: Lee Eun Kyoung , Kim Hye Jee , Lee Sang-Yoon , Song Su Jeong , Yu Hyeong Gon 
Published: March 2023

AbstractWe investigated the associations between retinal vascular geometric measurements and idiopathic epiretinal membrane (ERM). Whether changes in retinal vascular geometry are independent of systemic cardiovascular risk factors was also evaluated. This retrospective, cross sectional study included 98 patients with idiopathic ERM, and 99 healthy age-matched controls. Quantitative retinal vascular parameters were measured from digital retinal fundus photographs using a semi-automated computer-assisted program. Multivariate logistic regression analyses were performed to evaluate associations between retinal vascular geometric parameters and the presence of idiopathic ERM after adjusting for systemic cardiovascular risk factors. There was no significant difference in the baseline characteristics of the two groups, except that the ERM group had a higher proportion of females than the control group. In multivariate regression analyses, female sex (odds ratio [OR] 0.402; 95% CI 0.196–0.802; P = 0.011), wider retinal venular caliber (OR 16.852; 95% CI 5.384–58.997; P < 0.001) and decreased total fractal dimension (OR 0.156; 95% CI 0.052–0.440; P = 0.001) were associated with idiopathic ERM. Idiopathic ERM was associated with alterations in global retinal microvascular geometric parameters, wider retinal venules, and less complex vascular branching patterns, independent of cardiovascular risk factors.
Interaction analysis of ancestry-enriched variants with APOE-ɛ4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging
Authors: Granot-Hershkovitz Einat , Xia Rui , Yang Yunju , Spitzer Brian , Tarraf Wassim , Vásquez Priscilla M. , Lipton Richard B. , Daviglus Martha , Argos Maria , Cai Jianwen , Kaplan Robert , Fornage Myriam , DeCarli Charles , Gonzalez Hector M. , Sofer Tamar 
Published: March 2023

AbstractAPOE-ɛ4 risk on Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) differs between race/ethnic groups, presumably due to ancestral genomic background surrounding the APOE locus. We studied whether African and Amerindian ancestry-enriched genetic variants in the APOE region modify the effect of the APOE-ɛ4 alleles on Mild Cognitive Impairment (MCI) in Hispanics/Latinos. We defined African and Amerindian ancestry-enriched variants as those common in one Hispanic/Latino parental ancestry and rare in the other two. We identified such variants in the APOE region with a predicted moderate impact based on the SnpEff tool. We tested their interaction with APOE-ɛ4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) population and African Americans from the Atherosclerosis Risk In Communities (ARIC) study. We identified 5 Amerindian and 14 African enriched variants with an expected moderate effect. A suggestive significant interaction (p-value = 0.01) was found for one African-enriched variant, rs8112679, located in the ZNF222 gene fourth exon. Our results suggest there are no ancestry-enriched variants with large effect sizes of interaction effects with APOE-ɛ4 on MCI in the APOE region in the Hispanic/Latino population. Further studies are needed in larger datasets to identify potential interactions with smaller effect sizes.
In vitro evaluation of genipin-crosslinked gelatin hydrogels for vocal fold injection
Authors: Ng Wan-Chiew , Lokanathan Yogeswaran , Fauzi Mh Busra , Baki Marina Mat , Zainuddin Ani Amelia , Phang Shou Jin , Azman Mawaddah 
Published: March 2023

AbstractGlottic insufficiency is one of the voice disorders affecting all demographics. Due to the incomplete closure of the vocal fold, there is a risk of aspiration and ineffective phonation. Current treatments for glottic insufficiency include nerve repair, reinnervation, implantation and injection laryngoplasty. Injection laryngoplasty is favored among these techniques due to its cost-effectiveness and efficiency. However, research into developing an effective injectable for the treatment of glottic insufficiency is currently lacking. Therefore, this study aims to develop an injectable gelatin (G) hydrogel crosslinked with either 1-ethyl-3-(3-dimethylaminpropyl)carbodiimide hydrochloride) (EDC) or genipin (gn). The gelation time, biodegradability and swelling ratio of hydrogels with varying concentrations of gelatin (6–10% G) and genipin (0.1–0.5% gn) were investigated. Some selected formulations were proceeded with rheology, pore size, chemical analysis and in vitro cellular activity of Wharton's Jelly Mesenchymal Stem Cells (WJMSCs), to determine the safety application of the selected hydrogels, for future cell delivery prospect. 6G 0.4gn and 8G 0.4gn were the only hydrogel groups capable of achieving complete gelation within 20 min, exhibiting an elastic modulus between 2 and 10 kPa and a pore size between 100 and 400 μm. Moreover, these hydrogels were biodegradable and biocompatible with WJMSCs, as > 70% viability were observed after 7 days of in vitro culture. Our results suggested 6G 0.4gn and 8G 0.4gn hydrogels as potential cell encapsulation injectates. In light of these findings, future research should focus on characterizing their encapsulation efficiency and exploring the possibility of using these hydrogels as a drug delivery system for vocal fold treatment.
Differences between recreational gamers and Internet Gaming Disorder candidates in a sample of Animal Crossing: New Horizons players
Authors: Wischert-Zielke Moritz , Barke Antonia 
Published: March 2023

AbstractThroughout the last decade, research has considered players’ gaming motives as risk and the perceived social support (PSS) as protective factors in the context of Internet Gaming Disorder (IGD). However, the literature is lacking diversity regarding the representation of female gamers as well as of casual and console-based games. The aim of this study was to assess IGD, gaming motives, and PSS comparing recreational gamers and IGD candidates in a sample of Animal Crossing: New Horizons players. A total of 2909 ACNH players (93.7% of them female gamers) took part in an online survey which collected demographic, gaming-related, motivational, and psychopathologic data. Using the cut-off of at least five positive answers to the IGDQ, potential IGD candidates were identified. ACNH players reported a high prevalence rate for IGD (10.3%). IGD candidates differed from recreational players regarding age, sex, and game-related, motivational, and psychopathological variables. A binary logistic regression model was computed to predict membership in the potential IGD group. Age, PSS, escapism and competition motives as well as psychopathology were significant predictors. To discuss IGD in the context of casual gaming, we consider demographic, motivational, and psychopathological player characteristics as well as game design and the COVID-19 pandemic. IGD research needs to broaden its focus concerning game types as well as gamer populations.
Prokineticin 1 is a novel factor regulating porcine corpus luteum function
Authors: Baryla Monika , Goryszewska-Szczurek Ewelina , Kaczynski Piotr , Balboni Gianfranco , Waclawik Agnieszka 
Published: March 2023

AbstractProkineticin 1 (PROK1) is a pleiotropic factor secreted by endocrine glands; however, its role has not been studied in the corpus luteum (CL) during pregnancy in any species. The present study aimed to investigate the contribution of PROK1 in regulating processes related to porcine CL function and regression: steroidogenesis, luteal cell apoptosis and viability, and angiogenesis. The luteal expression of PROK1 was greater on Days 12 and 14 of pregnancy compared to Day 9. PROK1 protein expression during pregnancy increased gradually and peaked on Day 14, when it was also significantly higher than that on Day 14 of the estrous cycle. Prokineticin receptor 1 (PROKR1) mRNA abundance increased on Days 12 and 14 of pregnancy, whereas PROKR2 elevated on Day 14 of the estrous cycle. PROK1, acting via PROKR1, stimulated the expression of genes involved in progesterone synthesis, as well as progesterone secretion by luteal tissue. PROK1–PROKR1 signaling reduced apoptosis and increased the viability of luteal cells. PROK1 acting through PROKR1 stimulated angiogenesis by increasing capillary-like structure formation by luteal endothelial cells and elevating angiogenin gene expression and VEGFA secretion by luteal tissue. Our results indicate that PROK1 regulates processes vital for maintaining luteal function during early pregnancy and the mid-luteal phase.
DTUMOS, digital twin for large-scale urban mobility operating system
Authors: Yeon Hyeokju , Eom Taebum , Jang Kitae , Yeo Jiho 
Published: March 2023

AbstractThe advancement of digital twin technology has significantly impacted the utilization of virtual cities in the realm of smart cities and mobility. Digital twins provide a platform for the development and testing of various mobility systems, algorithms, and policies. In this research, we introduce DTUMOS, a digital twin framework for urban mobility operating systems. DTUMOS is a versatile, open-source framework that can be flexibly and adaptably integrated into various urban mobility systems. Its novel architecture, combining an AI-based estimated time of arrival model and vehicle routing algorithm, allows DTUMOS to achieve high-speed performance while maintaining accuracy in the implementation of large-scale mobility systems. DTUMOS exhibits distinct advantages in terms of scalability, simulation speed, and visualization compared to current state-of-the-art mobility digital twins and simulations. The performance and scalability of DTUMOS are validated through the use of real data in large metropolitan cities including Seoul, New York City, and Chicago. DTUMOS’ lightweight and open-source environment present opportunities for the development of various simulation-based algorithms and the quantitative evaluation of policies for future mobility systems.
Proteomics analysis of serum from thymoma patients
Authors: Li Jiaduo , Qi Guoyan , Liu Yaling 
Published: March 2023

AbstractThymoma is the most common malignant tumor in thymic epithelial tumors (TETS). This study aimed to identify the changes in serum proteomics in patients with thymoma. Proteins were extracted from twenty patients with thymoma serum and nine healthy controls and prepared for mass spectrometry (MS) analysis. Data independent acquisition (DIA) quantitative proteomics technique was used to examine the serum proteome. Differential proteins of abundance changes in the serum were identified. Bioinformatics was used to examine the differential proteins. Functional tagging and enrichment analysis were conducted using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. The string database was used to assess the interaction of different proteins. In all, 486 proteins were found in all samples. There were differences in 58 serum proteins between patients and healthy blood donors, 35 up-regulated and 23 down-regulated. These proteins are primarily exocrine and serum membrane proteins involved in controlling immunological responses and antigen binding, according to GO functional annotation. KEGG functional annotation showed that these proteins play a significant role in the complement and coagulation cascade and the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signal pathway. Notably, the KEGG pathway (complement and coagulation cascade) is enriched, and three key activators were up-regulated: von willebrand factor (VWF), coagulation factor v (F5) and vitamin k-dependent protein c (PC). Protein–protein interaction (PPI) analysis showed that six proteins ((VWF, F5, thrombin reactive protein 1 (THBS1), mannose-binding lectin-associated serine protease 2 (MASP2), apolipoprotein B (APOB), and apolipoprotein (a) (LPA)) were up-regulated and two proteins (Metalloproteinase inhibitor 1(TIMP1), ferritin light chain (FTL)) were down-regulated. The results of this study showed that several proteins involved in complement and coagulation cascades were up-regulated in the serum of patients.