bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence‐base for the beneficial effect of nutraceuticals in canine dermatological immune‐mediated inflammatory diseases — A literature review
Authors: van Amersfort Kelly , van der Lee Annette , Hagen‐Plantinga Esther 
Published: March 2023

AbstractBackgroundImmune‐mediated inflammatory diseases (IMIDs) are associated with an abnormal immune response, resulting in a disturbed homeostasis and chronic inflammation. Most canine dermatological IMIDs (cDIMIDs), such as allergies, autoimmune and immune‐mediated diseases, require long‐term treatment with immunosuppressive drugs with potential adverse effects. In general, nutraceuticals are thought to be safe. As a result, there is a tendency for the more frequent use of nutraceuticals in veterinary medicine.ObjectivesThe aim of this review was to present evidence‐based proof for the use of various nutraceuticals in the treatment of cDIMIDs and, where possible, to provide conclusions to guide their use in veterinary dermatological practice.MethodsA comprehensive literature search on common cDIMIDs and nutraceuticals was performed. Only peer‐reviewed articles published in English and related to the study topic were included. A total of 64 eligible publications were classified in five categories based on study design and substantively assessed on additional criteria such as standardisation of diets and number of included animals. For final appraisal, classification of major, minor or no evidence was used whereby efficacy was based on clinical outcome measurements.ConclusionsMinor evidence for the beneficial use of several nutraceuticals, including essential fatty acids, niacinamide and probiotics, was found for treatment of specific cDIMIDs. These nutraceuticals may improve clinical signs or reduce the required dose of concurrent medication (e.g. drug‐sparing effect) in some dogs. Some nutraceuticals also may be used for long‐term maintenance therapy. Despite some promising findings, major evidence for the use of nutraceuticals in cDIMIDs is lacking, warranting further research.
Volume Loss and Recovery in Bovine Knee Meniscus Loaded in Circumferential Tension
Authors: Peloquin John M. , Santare Michael H. , Elliott Dawn M. 
Published: March 2023

AbstractLoad-induced volume change is an important aspect of knee meniscus function because volume loss creates fluid pressure, which minimizes friction and helps support compressive loads. The knee meniscus is unusual amongst cartilaginous tissues in that it is loaded not only in axial compression, but also in circumferential tension between its tibial attachments. Despite the physiologic importance of the knee meniscus' tensile properties, its volumetric strain in tension has never been directly measured, and predictions of volume strain in the scientific literature are inconsistent. In this study, we apply uniaxial tension to bovine knee meniscus and use biplanar imaging to directly observe the resulting three-dimensional volume change and unloaded recovery, revealing that tension causes volumetric contraction. Compression is already known to also cause contraction; therefore, all major physiologic loads compress and pressurize the meniscus, inducing fluid outflow. Although passive unloaded recovery is often described as slow relative to loaded loss, here we show that at physiologic strains the volume recovery rate in the meniscus upon unloading is faster than the rate of volume loss. These measurements of volumetric strain are an important step toward a complete theory of knee meniscus fluid flow and load support.
Nonlinear Thermomechanical Static and Dynamic Responses of Bidirectional Porous Functionally Graded Shell Panels and Experimental Verifications
Authors: Ramteke Prashik Malhari , Panda Subrata Kumar 
Published: March 2023

AbstractThe present article examines the nonlinear static/dynamic behavior of the functionally graded porous shell panel with variable geometrical shapes exposed to thermomechanical load. The higher-order shear deformation theory (HSDT) is employed to develop a finite element (FE)-based mathematical model. The geometric nonlinearity is incorporated using Green–Lagrange nonlinear strains (GLNS). Voigt's micromechanical model, in association with power-law (GT-I), sigmoid (GT-II) and exponential (GT-III) kinds of material grading patterns, is adopted to calculate the graded panel's effective properties. Also, even (PRT-I) and uneven (PRT-II) distributions of porosity are considered in the present work. The temperature-dependent (TD) properties are adopted in association with variable temperature fields, i.e., uniform (TD-I), linear (TD-II), and nonlinear (TD-III) for the computation of flexural responses. To compute the desired nonlinear responses, the direct iterative technique is utilized. Convergence is used to validate the established model's stability and correctness is further verified by comparing the current numerical data to published and experimental results. The experiment was carried out by fabricating a few natural fiber-reinforced linearly varying layerwise panels for the test run. The study is further extended to investigate the influence of design parameters on nonlinear static and transient data (flexural/stress) of the functionally graded curved/flat panel considering thermal environmental conditions.
Influence of Supercritical Water on the Composition and Distribution of Microelements in Resins, Asphaltenes, Kerogens, and Rocks of Tatarstan Domanik Deposits of Different Lithological Types
Authors: Nasyrova Z. R. , Kayukova G. P. , Gareev B. I. , Eskin A. A. , Vakhin A. V. 
Published: March 2023

Abstract
A comparative study of changes in the microelemental composition and distribution in resins, asphaltenes, and kerogens from Tatarstan Domanik rocks, occurring under the action of supercritical water (SCW) at 374°С and a pressure of 22–24 MPa, was made. The samples studied belong to different lithological types; they were taken from carbonate–siliceous deposits of the Romashkino and Tavel oilfields and from carbonate deposits of the Bavly oilfield. The specific features of distribution of different microelements (MEs) in rocks and rock organic matter (OM) components were revealed by inductively coupled plasma mass spectrometry (ICP-MS). The major MEs are Fe > Ti > Ni > Zn > V > Cr > Cu with the concentrations from 100 to 8600 ppm. The total ME content of rocks from these deposits is 1.14, 0.23, and 0.38%, respectively. The ME content of resins and asphaltenes does not exceed 0.3 and 2%, respectively. The highest ME content, 8%, is observed in kerogens. The carbonate–siliceous rocks from different deposits with Сorg 7.07 and 1.90% differ from the carbonate rock with low Сorg (0.33%) in that the ME concentration in them is maximal. On the other hand, the ME content of resins and asphaltenes from the carbonate rocks is higher compared to the carbonate–siliceous rock samples. The concentrations of Fe, Cu, As, Se, Pb, and Bi in kerogens of all the types decrease under the action of SCW. In the transformed resins and asphaltenes from carbonate–siliceous rocks, the V and Ni concentrations appreciably decrease, whereas in kerogens their concentrations do not change noticeably. The demetalation processes lead to the ME redistribution between the OM components and mineral surface of the rocks.
Shortwave Infrared Imaging Enables High-Contrast Fluorescence-Guided Surgery in Neuroblastoma
Authors: Privitera Laura , Waterhouse Dale J. , Preziosi Alessandra , Paraboschi Irene , Ogunlade Olumide , Da Pieve Chiara , Barisa Marta , Ogunbiyi Olumide , Weitsman Gregory , Hutchinson J. Ciaran , Cross Kate , Biassoni Lorenzo , Stoyanov Danail , Sebire Neil , Beard Paul , De Coppi Paolo , Kramer-Marek Gabriela , Anderson John , Giuliani Stefano 
Published: March 2023

Abstract

Fluorescence-guided surgery is set to play a pivotal role in the intraoperative management of pediatric tumors. Shortwave infrared imaging (SWIR) has advantages over conventional near-infrared I (NIR-I) imaging with reduced tissue scattering and autofluorescence. Here, two NIR-I dyes (IRDye800CW and IR12), with long tails emitting in the SWIR range, were conjugated with a clinical-grade anti-GD2 monoclonal antibody (dinutuximab-beta) to compare NIR-I and SWIR imaging for neuroblastoma surgery. A first-of-its-kind multispectral NIR-I/SWIR fluorescence imaging device was constructed to allow an objective comparison between the two imaging windows. Conjugates were first characterized in vitro. Tissue-mimicking phantoms, imaging specimens of known geometric and material composition, were used to assess the sensitivity and depth penetration of the NIR-I/SWIR device, showing a minimum detectable volume of ∼0.9 mm3 and depth penetration up to 3 mm. In vivo, fluorescence imaging using the NIR-I/SWIR device showed a high tumor-to-background ratio (TBR) for both dyes, with anti–GD2-IR800 being significantly brighter than anti–GD2-IR12. Crucially, the system enabled higher TBR at SWIR wavelengths than at NIR-I wavelengths, verifying SWIR imaging enables high-contrast delineation of tumor margins. This work demonstrates that by combining the high specificity of anti-GD2 antibodies with the availability and translatability of existing NIR-I dyes, along with the advantages of SWIR in terms of depth and tumor signal-to-background ratio, GD2-targeted NIR-I/SWIR-guided surgery could improve the treatment of patients with neuroblastoma, warranting investigation in future clinical trials.

Significance:
Multispectral near-infrared I/shortwave infrared fluorescence imaging is a versatile system enabling high tumor-to-background signal for safer and more complete resection of pediatric tumors during surgery.
Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy
Authors: Borek Bartlomiej , Nowicka Julita , Gzik Anna , Dziegielewski Marek , Jedrzejczak Karol , Brzezinska Joanna , Grzybowski Marcin , Stanczak Paulina , Pomper Paulina , Zagozdzon Agnieszka , Rejczak Tomasz , Matyszewski Krzysztof , Golebiowski Adam , Olczak Jacek , Lisiecki Kamil , Tyszkiewicz Magdalena , Kania Magdalena , Piasecka Sylwia , Cabaj Anna , Dera Paulina , Mulewski Krzysztof , Chrzanowski Jacek , Kusmirek Damian , Sobolewska Elzbieta , Magdycz Marta , Mucha Lukasz , Masnyk Marek , Golab Jakub , Nowotny Marcin , Nowak Elzbieta , Napiorkowska-Gromadzka Agnieszka , Pikul Stanislaw , Jazwiec Radoslaw , Dzwonek Karolina , Dobrzanski Pawel , Meyring Michael , Skowronek Krzysztof , Iwanowski Piotr , Zaslona Zbigniew , Blaszczyk Roman 
Published: March 2023

Abstract

Pharmacologic inhibition of the controlling immunity pathway enzymes arginases 1 and 2 (ARG1 and ARG2) is a promising strategy for cancer immunotherapy. Here, we report the discovery and development of OATD-02, an orally bioavailable, potent arginases inhibitor. The unique pharmacologic properties of OATD-02 are evidenced by targeting intracellular ARG1 and ARG2, as well as long drug-target residence time, moderate to high volume of distribution, and low clearance, which may jointly provide a weapon against arginase-related tumor immunosuppression and ARG2-dependent tumor cell growth. OATD-02 monotherapy had an antitumor effect in multiple tumor models and enhanced an efficacy of the other immunomodulators. Completed nonclinical studies and human pharmacokinetic predictions indicate a feasible therapeutic window and allow for proposing a dose range for the first-in-human clinical study in patients with cancer.

Significance:
We have developed an orally available, small-molecule intracellular arginase 1 and 2 inhibitor as a potential enhancer in cancer immunotherapy. Because of its favorable pharmacologic properties shown in nonclinical studies, OATD-02 abolishes tumor immunosuppression induced by both arginases, making it a promising drug candidate entering clinical trials.
USP10 Regulates ZEB1 Ubiquitination and Protein Stability to Inhibit ZEB1-Mediated Colorectal Cancer Metastasis
Authors: Sun Lei , Yu Jia , Guinney Justin , Qin Bo , Sinicrope Frank A. 
Published: March 2023

AbstractZinc finger E-box–binding homeobox 1 (ZEB1) is a transcription factor that can promote tumor invasion and metastasis by inducing epithelial-to-mesenchymal transition (EMT). To date, regulation of ZEB1 by RAS/RAF signaling remains unclear, and few studies have examined posttranslation modification of ZEB1, including its ubiquitination. In human colorectal cancer cell lines with RAS/RAF/MEK/ERK activation, an interaction of ZEB1 with the deubiquitinase ubiquitin-specific protease 10 (USP10) was identified whereby USP10 modifies ZEB1 ubiquitination and promotes its proteasomal degradation. Regulation of the USP10–ZEB1 interaction by MEK–ERK signaling was shown whereby constitutive activation of ERK can phosphorylate USP10 at Ser236 to impair its interaction with ZEB1 and enable ZEB1 protein stabilization. Stabilized ZEB1 was shown to promote colorectal cancer metastatic colonization in a mouse tail vein injection model. Conversely, MEK–ERK inhibition blocked USP10 phosphorylation and enhanced the USP10–ZEB1 interaction shown to suppress ZEB1-mediated tumor cell migration and metastasis. In conclusion, we demonstrate a novel function of USP10 in the regulation of ZEB1 protein stability and its ability to mediate tumor metastasis in a preclinical model.Implications:The MEK–ERK-regulated interaction of USP10 with ZEB1 can promote the proteasomal degradation of ZEB1 and thereby suppress its demonstrated ability to mediate tumor metastasis.
A phased process to reintroduce a hand-reared infant Tonkean macaque to her natal group
Authors: De Marco Arianna , Sanna Andrea , Cozzolino Roberto , Thierry Bernard 
Published: March 2023

Abstract
Reintroduction of separated individuals into their social group is a major problem in the management of captive group of non-human primates. Here we report a case in captive Tonkean macaques in which a female infant was abandoned by her mother after birth, then removed, hand-reared, and reintroduced after weaning to her original group in several stages. After the initial phase of separation, a period of habituation to group members followed during which the infant was brought to the front of the group enclosure daily for two months. We then started a phased reintroduction process that lasted a year. Because the biological mother was the group member most attracted to the infant, the process began by allowing the two individuals to interact. In the next stages, we introduced the infant to the other individuals one after the other, starting with the females. Females then acted as protectors against potential male aggression. At the age of one year and two months, the introduced individual had fully integrated her original group. Two years later, she appeared to behave like the other group members. This report shows that a phased process can be used to reintroduce an infant to a macaque group containing several adult females and males.
A House of Worship for Every Religious Community: The History of a Mālikī Fatwā
Authors: Safran Janina 
Published: March 2023

Abstract
This essay traces the incorporation of a sixth/twelfth century fatwā supporting the construction of churches in North Africa in the Mālikī madhhab and provides insight into practices of Mālikī legal interpretation in the Maghrib in the ninth/fifteenth century. In his fatwā, the Cordoban jurist Ibn al-Ḥājj (d. 529/1134) addressed a novel situation involving the relocation of Christians from al-Andalus. This fatwā was selected by the Tunisian jurist al-Burzulī (d. 841/1438) for commentary in his Jāmiʿ masāʾil al-aḥkām. He discussed Ibn al-Ḥājj’s opinions with reference to al-Mudawwana and al-Wāḍiḥa, and later commentaries, and made a connection to church building in Tunis. In the late ninth/fifteenth century, three jurists writing in response to anti-Jewish attacks in Tamanṭīṭ, in the Tuwāt oasis (Algeria), cited Ibn al-Ḥājj’s fatwā, as redacted by al-Burzulī, in their opinions on the destruction of a local synagogue. Each jurist treated Ibn al-Ḥājj’s fatwā as a relevant legal precedent. At the same time, each reevaluated the parameters of Mālikī debate about non-Muslim houses of worship to assert his distinct opinion about the synagogue of Tamanṭīṭ and the position of the Mālikī madhhab on non-Muslim houses of worship in Muslim lands.
Israel and the Nations: Proselytes and Apostates in 2 Baruch
Authors: Dik John 
Published: March 2023

Abstract
In this article I explore how God’s people is constituted in 2 Baruch and in which relation it stands to the nations, an issue which has not yet been dealt with in detail in recent research. It will be shown that the author, writing after the destruction of the temple in 70 CE, stresses the role of torah and true worship to encourage his addresses as Israel. In doing so, he creates a clear dichotomy between Israel and the nations to uphold group identity. However, in 2 Bar. 41–42 the firmly established walls of Israel seem to crumble, because those from Israel become apostates whereas those from the nations join God’s people. This passage is analyzed in more detail and its socio-historical background is explored, including the topics of assimilation, inter-marriage, and the joining of a Christian community.
Discourses on Research Freedom in the Academic Study of Religion. An Overview
Authors: Severino Valerio S. 
Published: March 2023

Abstract
The present essay aims at exploring the issue of the freedom of research in the Academic Study of Religion. This essay brings together questions, arguments, and narratives in the framework of which the issue has been addressed and expressed. By adopting the approach of the ‘discursive research’, I seek to trace the production of the meaning of ‘freedom’ that is legitimated and shared in the Academic Study of Religion. I shall give a breakdown of this process of meaning-production along the following lines: the authority, the rights, and the impartiality of science particularly with regard to both the concept of ‘(Religious)Value-Free’ and the program of the ‘academic freedom from religion’. Besides I describe a counter-narrative based on what I may call ‘Non-Religious-Value’-Free and the academic program of the ‘autonomy of religion’. Eventually, I acknowledge a complementarity between the two narratives, as well as between the notions of facts-given and god/church-given freedom. The central takeaway of the essay is the recognition of a binary opposition between the senses of freedom along these lines.
Evaluation of antioxidant enzymes in the female genital fluid of the bat Corynorhinus mexicanus during sperm storage
Authors: Campos-Rentería Angie Carolina , Rodríguez-Tobón Ahiezer , Salame-Méndez Arturo , León-Galván Miguel Ángel , Arenas-Ríos Edith 
Published: March 2023

Abstract
Female Corynorhinus mexicanus bats store sperm for three months. One cause of the death of sperm is the action of reactive oxygen species (ROS). Three antioxidant enzymes – superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) – regulate the REDOX state of the environment in which gametes are stored. The aim of this study was to evaluate antioxidant enzymatic activity in female genital fluid during the period of sperm storage (October-December). The activity of the enzymes in the female bats’ genital fluid was determined by spectrophotometry. SOD activity was 20 USOD/ml/min in each month. Total GPX activity was 70 UGPX/ml/min in October, but increased in November and December to 145 UGPX/ml/min. Specific CAT activity was 2000 UK/ml/min in October, but in November it increased to 16 000 UK/ml/min, then to 32 000 UK/ml/min in December. The ROS fluorescence indices in the sperm ranged from 3000 to 8000 with no significant differences. These data show that antioxidant enzymes participate in the maintenance of sperm viability in the female reproductive tract of C. mexicanus.
Planning for the Aftermath. Longue Durée Histories for a New International Legal Order in Kelsen, Lauterpacht and De Visscher
Authors: Giltaij Jacob 
Published: March 2023

Abstract
As early as the 1930s, the development of plans for an international legal order to be created in the aftermath of the Second World War were commonplace. This particularly concerned a group of refugee scholars hailing from the German-speaking academic world. The plans of three scholars that were personally affected by the Nazi regime are discussed, those of Hans Kelsen, Hersch Lauterpacht and Charles De Visscher. This contribution compares the plans of the three scholars as formulated in the period between 1934 and 1947, as well as the historical narratives at their core, and ventures to answer the question whether these narratives should be seen as ‘invented traditions’ or that the scholars perceive them as significant and crucial stages of development at the basis of their plans for a post-War international legal order.
Role of Gender Policies and Laws in Enhancing Women’s Participation in the Resolution of Land Conflicts
Authors: Mutuku Benson , Krumeich Anja , Alaii Jane , Hubertus van den Borne , Westendorp Ingrid 
Published: March 2023

Abstract
Gender mainstreaming is a strategy to end women’s exclusion and further gender equality by using general policies and laws. The Government of Kenya has made strides in realising gender equality with the adoption of different general and gender-specific policies and laws. The reality is, however, that gender equality is far from being achieved across the country. With a focus on land conflicts, this article seeks to examine gender policies and law frameworks that intend to enhance women’s participation in the resolution of land conflicts; what progress has been achieved; and the gaps in terms of making these legal frameworks a reality. The study concludes that empirical studies on the impact of gender policies and laws that aim to enhance women’s participation in resolution of land conflicts are lacking across the country calling therefore for more research that seeks to evaluate the impact of the policies and laws on the ground.
The European Union’s Space Diplomacy: Contributing to Peaceful Co-operation?
Authors: Riddervold Marianne 
Published: March 2023

Summary
The European Union (EU) has become a key player in space, second only to that of the USA. This article discusses what type of diplomatic actor the EU is in space by exploring whether it contributes to peaceful co-operation or if the EU — due to increasing geopolitical competition on Earth — is developing into a traditional realist actor. For this purpose, it applies three analytically distinct models of EU space policies, applicable also to other Global Commons areas. It finds that the EU does not treat space as an area of geopolitical competition. Instead, it contributes to space diplomacy through its focus on regulating and institutionalising space activities. However, rather than being driven by ‘the space flight idea’, the EU is committed to the peaceful development of space mainly for economic, strategic and societal purposes, in line with what one would expect of a liberal institutionalist actor.