bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of passive heat stress and passive heat acclimation on circulating extracellular vesicles: An exploratory analysis
Authors: Ravanelli Nicholas , Barry Hadiatou , Bain Anthony R. , Vachon Laurent , Martel Catherine , Gagnon Daniel 
Published: January 2023

AbstractThis retrospective exploratory analysis aimed to improve our understanding of the effect of passive heat stress and subsequent heat acclimation on the circulating concentration of extracellular vesicles (EVs). Healthy young adults (four females and six males, 25 ± 4 years of age, 1.72 ± 0.08 m in height and weighing 71.6 ± 9.0 kg) were heated with a water‐perfused suit before and after seven consecutive days of hot water immersion. Pre‐acclimation, participants were heated until oesophageal temperature increased to ∼1.4°C above baseline values. Post‐acclimation, participants were heated until oesophageal temperature reached the same absolute value as the pre‐acclimation visit (∼38.2°C). Venous blood samples were obtained before and at the end of passive heating to quantify plasma concentrations of EVs from all cell types (CSFE+), all cell types except erythrocytes (CSFE+MHCI+), platelets (CSFE+MHCI+CD41+), endothelial cells (CSFE+MHCI+CD62e+), red blood cells (CSFE+CD235a+) and leucocytes (CSFE+MHCI+CD45+) via flow cytometry. Passive heat stress increased the concentration of CFSE+EVs (46,150,000/ml [3,620,784, 88,679,216],P = 0.036), CFSE+MHCI+EVs (28,787,500/ml [9,851,127, 47,723,873],P = 0.021) and CSFE+MHCI+CD41+EVs (28,343,500/ml [9,637,432, 47,049,568],P = 0.008). The concentration of CSFE+MHCI+CD62e+EVs (94,230/ml [−55,099, 243,559],P = 0.187), CSFE+CD235a+EVs (−1,414/ml [−15,709, 12,882],P = 0.403) or CSFE+MHCI+CD45+EVs (−192,915/ml [−690,166, 304,336],P = 0.828) did not differ during heat stress. The change in circulating EVs during passive heat stress did not differ after heat acclimation (thermal state × acclimation interactions, allP ≥ 0.180). These results demonstrate that passive heat stress increases the circulating concentration of total and platelet EVs and that passive heat acclimation does not alter this increase.
Pulmonary ventilation and gas exchange during prolonged exercise in humans: Influence of dehydration, hyperthermia and sympathoadrenal activity
Authors: González‐Alonso José , Calbet José A. L. , Mora‐Rodríguez Ricardo , Kippelen Pascale 
Published: January 2023

AbstractThe mechanisms driving hyperthermic hyperventilation during exercise are unclear. In a series of retrospective analyses, we evaluated the impact of combined versus isolated dehydration and hyperthermia and the effects of sympathoadrenal discharge on ventilation and pulmonary gas exchange during prolonged intense exercise. In the first study, endurance‐trained males performed two submaximal cycling exercise trials in the heat. On day 1, participants cycled until volitional exhaustion (135 ± 11 min) while experiencing progressive dehydration and hyperthermia. On day 2, participants maintained euhydration and core temperature (Tc) during a time‐matched exercise (control). At rest and during the first 20 min of exercise, pulmonary ventilation (), arterial blood gases, CO2 output and O2 uptake were similar in both trials. At 135 ± 11 min, however, was elevated with dehydration and hyperthermia, and this was accompanied by lower arterial partial pressure of CO2, higher breathing frequency, arterial partial pressure of O2, arteriovenous CO2 and O2 differences, and elevated CO2 output and unchanged O2 uptake despite a reduced pulmonary circulation. The increased was closely related to the rise in Tc and circulating catecholamines (R2 ≥ 0.818, P ≤ 0.034). In three additional studies in different participants, hyperthermia independently increased to an extent similar to combined dehydration and hyperthermia, whereas prevention of hyperthermia in dehydrated individuals restored to control levels. Furthermore, adrenaline infusion during exercise elevated both Tc and . These findings indicate that: (1) adjustments in pulmonary gas exchange limit homeostatic disturbances in the face of a blunted pulmonary circulation; (2) hyperthermia is the main stimulus increasing ventilation during prolonged intense exercise; and (3) sympathoadrenal activation might partly mediate the hyperthermic hyperventilation.
Origami With Rotational Symmetry: A Review on Their Mechanics and Design
Authors: Lu Lu , Leanza Sophie , Zhao Ruike Renee 
Published: January 2023

Abstract
Origami has emerged as a powerful mechanism for designing functional foldable and deployable structures. Among various origami patterns, a large class of origami exhibits rotational symmetry, which possesses the advantages of elegant geometric shapes, axisymmetric contraction/expansion, and omnidirectional deployability, etc. Due to these merits, origami with rotational symmetry has found widespread applications in various engineering fields such as foldable emergency shelters, deformable wheels, deployable medical stents, and deployable solar panels. To guide the rational design of origami-based deployable structures and functional devices, numerous works in recent years have been devoted to understanding the geometric designs and mechanical behaviors of rotationally symmetric origami. In this review, we classify origami structures with rotational symmetry into three categories according to the dimensional transitions between their deployed and folded states as three-dimensional to three-dimensional, three-dimensional to two-dimensional, and two-dimensional to two-dimensional. Based on these three categories, we systematically review the geometric designs of their origami patterns and the mechanical behaviors during their folding motions. We summarize the existing theories and numerical methods for analyzing and designing these origami structures. Also, potential directions and future challenges of rotationally symmetric origami mechanics and applications are discussed. This review can provide guidelines for origami with rotational symmetry to achieve more functional applications across a wide range of length scales.
Alcubierre warp drive in spherical coordinates with some matter configurations
Authors: Abellán Gabriel , Bolivar Nelson , Vasilev Ivaylo 
Published: January 2023

AbstractIn this work we introduce the Alcubierre warp metric using spherical symmetry. In this way we write the Einstein equations for a perfect fluid and for an anisotropic fluid with cosmological constant. Analysing the energy conditions for both cases, we find that these cases are flexible enough to allow them to be satisfied. We also find that in the time-independent case of the warp bubble, the metric admits a timelike Killing vector and all the energy conditions are satisfied except for the strong energy condition. Moreover, in the time-independent case a barotropic equation of state known from cosmological models naturally arises.
The application of hyperspectral core imaging for oil and gas
Authors: Linton Paul , Kosanke Tobi , Greene James , Porter Benjamin 
Published: January 2023

Abstract
Hyperspectral core imaging as a commercial technology is fairly new to the oil and gas industry, providing a rapid and non-destructive method for mapping mineralogy of drill core and cuttings. The technology makes use of infrared spectrometers that collect imagery across the visible, near infrared, short-wave infrared and thermal (long-wave) infrared range that contains information related to a variety of mineral species, and in some cases including mineral chemistry and texture. In this paper we illustrate how the mineralogical information can be used directly for a variety of applications relevant to reservoir quality, including mineral mapping, sedimentological mapping and upscaling of micro information to the well scale. Statistical analysis allows the data to be used to segment cores into different rock types, and via calibration to quantitative mineralogical techniques, the data can be used to construct continuous curves of quantitative mineralogy, total organic content and production parameters.
Cervical Cancer Stage at Diagnosis and Survival among Women ≥65 Years in California
Authors: Cooley Julianne J.P. , Maguire Frances B. , Morris Cyllene R. , Parikh-Patel Arti , Abrahão Renata , Chen Hui A. , Keegan Theresa H.M. 
Published: January 2023

AbstractBackground:Through adequate screening and follow-up, cervical cancer can be prevented or detected at early-stage (stage I), which is related to excellent survival. Current guidelines recommend discontinuing screening for women ≥65 years with history of normal Pap and/or HPV tests, potentially leaving this age group vulnerable. This study examined late-stage disease in a population-based cohort.Methods:Using California Cancer Registry data, we identified 12,442 patients ages ≥21 years with a first primary cervical cancer diagnosed during 2009–2018. Proportions of late-stage disease (stages II–IV) and early- and late-stage 5-year relative survival are presented by the age group. Among patients ages ≥65 years, multivariable logistic regression estimated associations of sociodemographic and clinical characteristics with late-stage cervical cancer.Results:Nearly one fifth of patients (n = 2,171, 17.4%) were ≥65 years. More women ages ≥65 years (71%) presented with late-stage disease than younger women (48% in patients ages &lt;65). Late-stage 5-year relative survival was lower for women ≥65 years (23.2%–36.8%) compared with patients &lt;65 (41.5%–51.5%). Characteristics associated with late-stage cervical cancer in women ≥65 years included older age [odds ratio (OR), 1.02; 95% confidence interval (CI), 1.01–1.04; each year], non-adenocarcinoma histologic subtypes, and comorbidities (OR, 1.59; 95% CI, 1.21–2.08).Conclusions:There remains a significant burden of advanced cervical cancer in women ≥65.Impact:Efforts should be made to better understand how the current screening paradigm is failing women of 65 years and older. Future work should focus on determining past screening history, lapses in follow-up care, and non-invasive testing approaches.
Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality
Authors: Holtan Shernan G. , Savid-Frontera Constanza , Walton Kelly , Eaton Anne A. , Demorest Connor , Hoeschen Andrea , Zhang Ling , Reid Kayla , Kurian Tony , Sayegh Zena , Julia Estefania , Maakaron Joseph , Bachanova Veronika , Jurdi Najla El , MacMillan Margaret L. , Weisdorf Daniel J. , Felices Martin , Miller Jeffrey S. , Blazar Bruce R. , Davila Marco L. , Betts Brian C. 
Published: January 2023

AbstractPurpose:Acute and chronic GVHD remain major causes of transplant-related morbidity and mortality (TRM) after allogeneic hematopoietic cell transplantation (alloHCT). We have shown CD83 chimeric antigen receptor (CAR) T cells prevent GVHD and kill myeloid leukemia cell lines. In this pilot study, we investigate CD83 expression on GVHD effector cells, correlate these discoveries with clinical outcomes, and evaluate critical therapeutic implications for transplant recipients.Experimental Design:CD83 expression was evaluated among circulating CD4+ T cells, B-cell subsets, T follicular helper (Tfh) cells, and monocytes from patients with/without acute or chronic GVHD (n = 48 for each group), respectively. CD83 expression was correlated with survival, TRM, and relapse after alloHCT. Differential effects of GVHD therapies on CD83 expression was determined.Results:CD83 overexpression on CD4+ T cells correlates with reduced survival and increased TRM. Increased CD83+ B cells and Tfh cells, but not monocytes, are associated with poor posttransplant survival. CD83 CAR T eliminate autoreactive CD83+ B cells isolated from patients with chronic GVHD, without B-cell aplasia as observed with CD19 CAR T. We demonstrate robust CD83 antigen density on human acute myeloid leukemia (AML), and confirm potent antileukemic activity of CD83 CAR T in vivo, without observed myeloablation.Conclusions:CD83 is a promising diagnostic marker of GVHD and warrants further investigation as a therapeutic target of both GVHD and AML relapse after alloHCT.
N6-Methyladenosine RNA Modifications Regulate the Response to Platinum Through Nicotinamide N-methyltransferase
Authors: Huang Hao , Zhao Guangyuan , Cardenas Horacio , Valdivia Andres Felipe , Wang Yinu , Matei Daniela 
Published: January 2023

AbstractDevelopment of resistance to platinum (Pt) in ovarian cancer remains a major clinical challenge. Here we focused on identifying epitranscriptomic modifications linked to Pt resistance. Fat mass and obesity-associated protein (FTO) is a N6-methyladenosine (m6A) RNA demethylase that we recently described as a tumor suppressor in ovarian cancer. We hypothesized that FTO-induced removal of m6A marks regulates the cellular response of ovarian cancer cells to Pt and is linked to the development of resistance. To study the involvement of FTO in the cellular response to Pt, we used ovarian cancer cells in which FTO was knocked down via short hairpin RNA or overexpressed and Pt-resistant (Pt-R) models derived through repeated cycles of exposure to Pt. We found that FTO was significantly downregulated in Pt-R versus sensitive ovarian cancer cells. Forced expression of FTO, but not of mutant FTO, increased sensitivity to Pt in vitro and in vivo (P &lt; 0.05). Increased numbers of γ-H2AX foci, measuring DNA double-strand breaks, and increased apoptosis were observed after exposure to Pt in FTO-overexpressing versus control cells. Through integrated RNA sequencing and MeRIP sequencing, we identified and validated the enzyme nicotinamide N-methyltransferase (NNMT), as a new FTO target linked to Pt response. NNMT was upregulated and demethylated in FTO-overexpressing cells. Treatment with an NNMT inhibitor or NNMT knockdown restored sensitivity to Pt in FTO-overexpressing cells. Our results support a new function for FTO-dependent m6A RNA modifications in regulating the response to Pt through NNMT, a newly identified RNA methylated gene target.
Abstract A001: Bridging the gap between cancer care service delivery and the sexual and gender minority communities: A scoping review of the literature
Authors: Jeames Sanford , Fernandez Britteny 
Published: January 2023

Abstract
While there has been an increase in health equity research, there is scarcely research focusing on health equity for cancer survivors who identify as LGBTQIA+ (Lesbian, Gay, Bisexual, Transgender, Queer, Intersex, Asexual, Pansexual and Two-Spirit). This is in part the result of a lack of routine collection of SOGI (Sexual Orientation and Gender Identity) data within the LGBTQIA+ community. Our research aims to analyze and discuss how labelling and terminology have both influenced medical practice and posed barriers and delays in care to the LGBT community over time. Further, examining whether the literature supports increasing LGBT experiences in interprofessional training. By identifying these gaps in the literature and in interprofessional training we hope to decrease barriers to timely and supportive cancer services. To examine the breadth of research on the LGBTQIA+ community and cancer, a scoping review methodology was utilized to identify knowledge and research gaps. This review examines literature published in the U.S, in academic journals between 1913 and 2021 to gain a greater understanding of how historical contexts, policy, and research have evolved alongside the growing visibility of the LGBTQIA+ community. The authors used a scoping review strategy outlined by Arksey and O’Malley (2005) to review the literature employing a comprehensive list of search terms for cancer and LGBTQIA+. Rayyan software was then utilized to organize the data as our team hand-searched the articles for inclusion (cancer, LGBTQIA) and exclusion (non-US, foreign language, prevention, screening) criteria. A total of 3,290 articles were included in the final analysis.
Citation Format: Sanford Jeames, Britteny Fernandez. Bridging the gap between cancer care service delivery and the sexual and gender minority communities: A scoping review of the literature [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr A001.
Abstract A003: Delays in diagnosis of AYA breast cancer and lack of breast health education
Authors: Peters Missy 
Published: January 2023

Abstract
INTRO) The average AYA breast cancer patient is diagnosed at a higher stage and has a higher mortality rate compared to their 40+ counterparts [1,2,3]. Ruddy et al. (2014) establish a higher prevalence of delayed diagnosis in AYA patients [4]. Delays in treatment of just 6 weeks have been linked to poorer 5-year survival rates [5]. In this study, we attempt to confirm the findings of Ruddy et al. and further define factors affecting delays in diagnosis. METHODS) We distributed an online survey via social media outlets to women diagnosed &lt;40 years old in the USA. We interpreted 455 responses. RESULTS) Our findings determined that 70% of respondents (n=320) made extra efforts after detecting an abnormality and taking steps to obtain a diagnosis. This includes those with prompt and delayed diagnosis. 36% of survivors faced delays in diagnosis (defined by 8+ weeks duration from detection to diagnosis). 62% of survivors say that a physician never educated them on breast health prior to diagnosis. 54% have not heard of breast self-awareness (BSA) and 54% incorrectly defined breast self-exams (BSE), suggesting confusion in this distinction. DISCUSSION) These data confirm earlier findings that 1) women under 40 face a significant rate of delayed diagnosis; and 2) patient perceptions and medical provider perceptions contribute to these delays. We propose that earlier diagnosis of breast cancer in young women will initiate quicker treatment interventions which have been shown to increase 5-year survival rates and lower long-term mortality rates in the AYA breast cancer population [5,6]. CONCLUSION) Greater efforts should be made to educate young women on breast health, and the medical community should be made aware of these challenges so they can properly evaluate and assist young women to receive a prompt diagnosis.
Citation Format: Missy Peters. Delays in diagnosis of AYA breast cancer and lack of breast health education [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr A003.
Abstract A005: Inhibition of ubiquitin receptor ADRM1 for the treatment of metastatic breast cancer
Authors: Andrews Christopher B. , Karanam Balasubramanyam , Yates Clayton 
Published: January 2023

Abstract
Adhesion-regulating molecule 1 (ADRM1) is a polyubiquitin receptor on the 26S proteasome. ADRM1 is upregulated in many cancers. In this study, we evaluated the potential prognostic and predictive value of ADRM1 in breast cancer patients. We determined the expression of ADRM1 and its relationship to breast cancer subtypes, using the Cancer Genome Atlas dataset that contained racial and clinical outcomes data totaling 1108 patients. The ADRM1 mRNA expression levels were divided into quartiles to designate the ADRM1 high versus low expression designation. Karanam et. al developed an orally available proteasome inhibitor bis-benzylidine piperidone (RA190), that binds to the ubiquitin receptor RPN13/ADRM1 on the 19S regulatory particle of the proteasome and directly kills cancer cells by triggering proteotoxic stress. RA190 binds to cysteine 88 of ADRM1/RPN13, triggering rapid accumulation of high-molecular-weight poly-ubiquitinated proteins resulting in apoptosis. Up284 is one of a second generation of small molecules that mimic RA190 activity. The objective of this study is to verify the role of ubiquitin receptor RPN13/ADRM1 in metastatic breast cancer samples of European American and African American patients and identify the safe combination of regimens of bortezomib in combination with Up289 to mitigate recurrence, metastasis and reduce mortality in AA TNBC/QNBC. Clinically, this will reveal a new, hitherto unknown targeted regimen for AA QNBC. From the biological perspective, it will provide insights into the underlying molecular changes that are associated with health disparities.Currently available treatments are unable to eradicate metastatic breast cancer specifically those classified as QNBC. Our preliminary analysis of Cancer Genome Atlas (TCGA) indicated that ADRM1 expression is highly expressed in AA versus EA breast cancer patients, resulting in a worse overall survival. Further analysis of ADRM1 in QNBC patients indicated that it was significantly elevated predominantly in African American patients with QNBC.
Citation Format: Christopher B. Andrews Jr., Balasubramanyam Karanam, Clayton Yates. Inhibition of ubiquitin receptor ADRM1 for the treatment of metastatic breast cancer [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr A005.