bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, Clinical Profile, and Maternal and Perinatal Outcomes of Hyperglycemia in Pregnancy in a Tertiary Care Hospital in South India
Authors: Khursheed Romana , Shivalingappa Jayanth , Maldar Arif , Dalal Anita 
Published: May 2023

Background:
Hyperglycemia in pregnancy (HIP) is an umbrella term for any degree of carbohydrate intolerance in pregnancy which carries risk of transgenerational transfer of metabolic disorders. The present observational study was carried out to know the prevalence, clinical profile, and maternal and perinatal outcome in different categories of HIP, in a South Indian setup.

Materials and Methods:
The study was carried out for 1 year at KAHER's Dr Prabhakar Kore Charitable Hospital, Belagavi in South India. The HIP was diagnosed by Diabetes in Pregnancy Study Group of India criteria and further categorized into gestational diabetes mellitus (GDM), gestational glucose intolerance (GGI), and diabetes in pregnancy (DIP). The prevalence, clinical profile, and maternal and perinatal outcome were analyzed in three groups.

Results:
The prevalence of HIP among pregnant population was found to be 17.47% in 1 year. 222 women (75.5%) had GDM, followed by 49 (17%) and 23 women (8%) presented with GGI and DIP, respectively. The maternal outcomes among HIP were cesarean delivery 230 (78.2), preterm labor 53 (18.02%), preeclampsia 50 (17.01%), premature rupture of membranes 34 (11.56%), and infections 33 (11.22%). The perinatal outcome recorded were neonatal intensive care unit admissions in 107 neonates (36.39%), hyperbilirubinemia in 44 neonates (15%), hypoglycemia in 79 neonates (26.8%), respiratory distress syndrome in 43 neonates (14.46%), and macrosomia in 44 fetuses (15%).

Conclusion:
Degree of hyperglycemia affects pregnancy outcomes. Continued surveillance of women in preconceptional, antenatal, and postnatal period ensures early diagnosis and management of glucose intolerance and helps in delaying the onset of overt diabetes.
To Study the Association between Daytime Sleepiness and Cognition as Tested by Stroop Test in Indian Medical Students
Authors: Khullar Shilpa , Singh Mitasha , Das Suman , Kamya  
Published: May 2023

Context:
Human populations have undergone a steady constant decline in sleep hours attributable to changes in environmental and social circumstances. Excessive daytime sleepiness has been associated with a decreased capacity to perform daily activities and cognitive decline all over the world particularly among students.

Aim:
The aim of our study was to see the association between excessive daytime sleepiness and cognitive function in Indian medical students.

Settings and Design:
It was a cross-sectional study conducted in a Government Medical College located in the Delhi/NCR region. Materials and Methods: The study included 60 healthy young volunteers in the 18–30 years age group of both sexes. The students were assessed for daytime sleepiness using the Epworth Sleepiness Scale (ESS). Color–Word Stroop Test was used to assess cognition in both the groups. Statistical Analysis: Data were expressed as mean ± standard deviation and analyzed using SPSS Software Version 21.

Results:
The average score of the ESS scale of the participants was 7.33 ± 2.20. In the Stroop Test, the reaction time of congruent trial and incongruent trial was 24.81 ± 7.76 and 31.15 ± 8.03 s, respectively. No significant correlation was seen between the ESS score and parameters of the “Stroop Test.”

Conclusion:
The reaction time of the incongruent trial was significantly higher as compared to the congruent trial (P < 0.05) in the Stroop Task. No significant correlation was seen between the ESS score and Stroop Test results.
A Single-Center Detection of Adult Patients with Advanced Periodontal Disease using Surgical Assessment and Cone-Beam Computed Tomography
Authors: Chandran Ajay , Preethanath Reghunathan S. , Gufran Khalid , Khan Mohammad Shoyab , Alqahtani Abdullah Saad , Chikkanna Meenakumari , Swarnalatha C , Babu J Suresh , Nayyar Abhishek Singh 
Published: May 2023

Context:
One of the major limitations of conventional radiological procedures is presence of considerable overlapping and lack of clear, three-dimensional information. Cone-beam computed tomography (CBCT) has emerged as an effective imaging modality in such situations offering high-quality images and lower radiation exposure to patients.

Aim:
The aim of the present study was to assess the role of CBCT in detection of intra-bony defects in patients with advanced periodontal disease.

Settings and Design:
The present study was designed as a prospective, observational study wherein patients aged between 35 and 55 years with advanced periodontal disease who were indicated for periodontal treatment in the form of periodontal surgeries were selected from the outpatient department based on defined inclusion and exclusion criteria.

Materials and Methods:
Sixty patients with chronic periodontitis with 12 teeth each including 6 anterior and 6 posterior teeth were selected for making measurements pre- and perioperatively while bone defects were measured first with the help of CBCT software installed in an individualized system devised to be used for storing and analyzing CBCT images and then during surgical intervention using standardized UNC-15 periodontal probe and compared.

Statistical Analysis Used:
Statistical analysis was done using SPSS version 18.0 (SPSS Inc., Chicago, IL, USA). The measurements obtained with the help of CBCT software installed in the personalized system and those obtained on surgical exploration were compared in each anterior and posterior tooth with the help of paired-sample t-test while Pearson's correlation® was used to test the correlation between the observed values. Level of statistical significance was set at P < 0.05.

Results:
The results were found to be highly significant both in terms of statistical (P value) and clinical® significance for various sites in the anterior and posterior teeth in all instances.

Conclusions:
From the observations made from the present study, it could be concluded that CBCT provided a highly precise assessment of bone topography equivalent to the judgment obtained during surgical exposure at the sites of interest preoperatively which helped in assessing the exact type and depth of defect present and helped optimizing surgical treatment planning.
Information and Communication Technology in Medical Education
Authors: Ferdoush Jannatul , Roy Biswas Rajat Sanker Roy , Khan Ikram Ullah , Momtaz Tashfia , Alam Jahangir , Morshed Md. Masud , Chowdhury Abhijit , Parveen Kohinoor , Ata Maliha , Jeenia Fathiha Tasmin 
Published: May 2023

Background:
Bangladesh is declared as “Digital Bangladesh” however, medical students are least acquainted with the necessary information and communication technology (ICT) knowledge in the context of medical education. We have conducted a survey to know about digital equipment ownership, therefore, carried out a self-reported assessment of knowledge and utilization of ICT in relation to educational and clinical development.

Materials and Methods:
A cross-sectional, multi-centered questionnaire survey was conducted among the medical students during the period of October 2019.

Results and Discussions:
In total 467 medical students responded to the questionnaire in which 92% of the students owned a Google android smartphone and accessed the Internet on their devices. Sixty-nine percent of students have (1–5) medical-related apps in their device and drug formulary apps most commonly used 43%. Fifty-nine percent of students have gained their present computer knowledge through self-learning. For study work with fellow student, 90% of students preferred Facebook group, WhatsApp, and Viber. While there was a range of variation in the usage of nonacademic search engines 72% of Google and no usages were found for more dedicated academic services such as PubMed and Medscape. According to 74% of students, inadequate integration of ICT knowledge into their syllabus culminated in insufficient future professional skills. All students were keen on a basic ICT learning program at the beginning of their medical courses.

Conclusion:
The study revealed that to prepare medical students for using ICT in their academic work adequately, introducing ICT training at the initial stage of the undergraduate program and designing the curriculum to develop a multiplicity of skills is essential in addition to an integrated teaching method.
COPD and glycopyrronium responsiveness assessment: An appraisal
Authors: Bhattacharyya Parthasarathi , Saha Dipanjan , Chatterjee Moumita , Sengupta Sayoni , Dey Debkanya , Banerjee Rajat 
Published: May 2023

ABSTRACT

Background:
Glycopyrronium bromide (a long-acting antimuscarinic agent: LAMA) appears pharmacokinetically suitable for testing bronchodilator responsiveness as salbutamol (short-acting β2-agonist: SABA). Exploring the feasibility, acceptability, degree of reversibility with glycopyrronium, and its comparison with that of salbutamol may be intriguing.

Methods:
New, consecutive, and willing outpatient attendees in the same season of the two consecutive years with chronic obstructive pulmonary disease (FEV1/FVC <0.07; FEV1 <80% of predicted) were subjected to serial responsiveness with inhalation of salbutamol first followed by 50 μg dry powder glycopyrronium [Salbutamol- Glycopyrronium] (phase-1) in the first year and glycopyrronium followed by salbutamol [Glycopyrronium- Salbutamol] (phase-2) in the following year. We looked for the acceptability, adverse reactions, and degree of changes in FEV1, FVC, FEV1/FVC, and FEF25-75 with comparison between the two groups.

Results:
The [Salbutamol- Glycopyrronium] group (n = 86) were similar in age, body mass index, and FEV1 to the [Glycopyrronium- Salbutamol] group (n = 88). Both the agents could make a significant (P <.0001) improvement in the parameters independently or as add-on when used serially in alternate orders. The intergroup difference at no stage was significant. The sensitive patients to salbutamol (n = 48), glycopyrronium (n = 44), and both (n = 12) have improvement of 165, 189, and 297 mL while a both-insensitive group (n = 70) had barely 44 mL of improvement. The protocol was universally accepted without any adverse events.

Conclusion:
Serial testing of salbutamol and glycopyrronium responsiveness in alternate orders provides an insight regarding the independent and the add-on effects of these two agents. About 40% of our chronic obstructive pulmonary disease patients had no clinically appreciable difference in FEV1 with the salbutamol + glycopyrronium combination inhalation.

Clinical Trial Registration:
ECR/159/Inst/WB/2013/RR-20
Systemic inflammatory response syndrome criteria (SIRS) and sepsis 3 criteria for assessing outcomes in sepsis: A prospective observational study
Authors: Chand Siddharth , Kumar Naresh , Mawari Govind , Sarkar Sayan , Daga Mradul Kumar , Raghu RV , Aarthi J. , Fatima Arisha 
Published: May 2023

ABSTRACT

Background:
Sepsis is a major cause of death in hospitalised patients worldwide. Most studies for assessing outcomes in sepsis are from the western literature. Sparse data from Indian settings are available comparing the systemic inflammatory response syndrome (SIRS), Sequential Organ Failure Assessment (SOFA) and quick SOFA (qSOFA) (sepsis 3 criteria) for assessing outcomes in sepsis. In this study, we aimed to compare the SIRS criteria and sepsis 3 criteria to assess disease outcome at day 28 (recovery/mortality) in a North Indian tertiary care teaching hospital.

Methods:
A prospective observational study was performed in the Department of Medicine from 2019 to early 2020. Patients admitted to the medical emergency with clinical suspicion of sepsis were included. Systemic inflammatory response syndrome, qSOFA and SOFA scores were calculated at the time of presentation to the hospital. Patients were followed through the course of their hospital stay.

Results:
Out of 149 patients, 139 were included in the analysis. Patients who died had significantly higher mean SOFA, qSOFA scores and mean change in SOFA score than patients who survived (P value <0.01). There was no statistical difference between recovery and deaths at similar SIRS scores. A 40.30% fatality rate was recorded. Systemic inflammatory response syndrome had low Area Under Curve (AUC) (0.47) with low sensitivity (76.8) and specificity (21.7). SOFA had the maximum AUC (0.68) compared to qSOFA (0.63) and SIRS (0.47). SOFA also had the maximum sensitivity (98.1) while the qSOFA score had the maximum specificity (84.3).

Conclusion:
SOFA and qSOFA scores had superior predictive ability as compared to the SIRS score in assessing mortality in sepsis patients.
A panoramic view of a cohort of obstructive sleep apnea patients on positive airway pressure therapy using cloud based telemonitoring devices
Authors: Haldar Arup , Halder Arpita C , Maity Somnath 
Published: May 2023

ABSTRACT

Background:
Positive airway pressure therapy is mainstay of treatment of obstructive sleep apnea (OSA). But long-term compliance with is poor with such therapy. A proactive and vigilant management may improve the PAP therapy usage. Cloud-based telemonitoring PAP devices offer an opportunity for proactive monitoring and prompt interventions related to PAP troubleshooting. This technology is also used in India for adult OSA patients. But we lack our own data on behavior of Indian patients as a cohort on PAP therapy. The present study is an attempt to look at the behavior a cohort of PAP users in OSA.

Methodology:
This study was planned as a retrospective analysis of data of OSA patients who were using a cloud-based PAP devices. First 100 patients were chosen for data retrieval that who was on this therapy. The data was obtained for those patients who were on PAP for at least 7 days and maximum follow-up was available up to 390 days. Descriptive statistical analysis has been carried out in the present study.

Results:
The number of male and female patients was 75 and 25, respectively. Overall good compliance was present in 66% of patients. 34% of patients were not compliant with PAP during follow-up. The compliance was statistically same in both the sexes (P = 0.8088). Incomplete data recovery was present in 17 patients and 11 (64.70%) were non-compliant among them. In the initial, 60 days non-compliant patients were more than compliant patients. The difference was lost in 60 to 90 days of use. The air leak was present more in the compliant group than non-compliant group (P = 0.0239). 75.75% of compliant patients had achieved AHI control, whereas 35.29% of non-compliant patients also achieved AHI control. But overall, AHI control was poor in non-compliant patients and 61.76% of non-compliant patients had an AHI uncontrolled.

Conclusions:
We conclude that 3/4th of the compliant patients achieve AHI control while 1/4th didn’t. This 1/4th population needs further exploration to determine the causes of poor AHI control. Cloud-based PAP devices give an easy opportunity to monitor patients of OSA. It gives an instant panoramic view of behavior of OSA patients on PAP therapy. The compliant patients can be tracked, and non-compliant patients can be segregated quickly.
Cardioprotective Effects of Paraoxanase 3 in a Dahl Salt-Sensitive Rat Model of Chronic Kidney Disease
Authors: Marellapudi Amulya 
Published: May 2023

Objective: Paraoxanases (Pon) are hydrolytic enzymes with three distinct isoforms. Decreased circulating Pon activity is associated with increased oxidant stress and adverse clinical outcomes in the setting of chronic kidney disease (CKD), yet the mechanism of action is unknown. We tested the hypothesis that Pon-3 is cardioprotective in a Dahl salt-sensitive model of hypertensive renal disease.
Methods: Ten week old, age-matched, Dahl salt-sensitive wildtype and Pon3 mutant male and female rats were maintained on eight percent high salt diets for eight weeks to initiate the salt-sensitive hypertensive renal disease characteristic of this model. After eight weeks, animals were euthanized and hearts were processed for histology. Echocardiography was performed to measure left ventricular function.
Results: By 8 weeks, mortality was observed in 18.2% of male SS-Pon3 KO rats on high salt; no mortality was observed in male SS male rats on high salt. In female rats, by 8 weeks 100% mortality was observed in SS-Pon3 KO rats on high salt diet while no mortality was observed in SS rats on high salt. High salt fed SS-Pon3 KO male rats that survived the echocardiography study demonstrated significantly decreased left ventricular end-systolic diameter and end-diastolic diameter, as well as significant increases in left ventricular relative wall thickness compared to age matched SS rats. Furthermore, SS-Pon3 KO rats demonstrated significantly increased heart-weight-to-body-weight ratio compared to age matched SS rats.
Conclusion: These findings suggest a cardioprotective role for PON-3 in the setting of salt-sensitive hypertensive renal disease.
Implementation of Journalistic Training at Extracurricular Broadcasting “Lensa Manduta” MAN 2 Tangerang
Authors: Wahyunengsih Wahyunengsih , Awaliyah Syifa , Ilma Ainun 
Published: May 2023

Writing is one of the journalistic skills that have a great influence on students so they are expected to disseminate information and even express feelings to the public through written language. Journalistic media for schools is a means of information about schools, education, entertainment, and persuasion. So, with journalism training, someone will be helped in honing creativity and talent. This study aims to observe the development of journalistic insights of students through journalistic training and provide solutions to the problem of lack of journalistic insights by motivating MAN 2 Tangerang students, especially members of the Broadcasting Extracurricular Lensa Manduta to be skilled in the field of writing. The method used in this research is the descriptive qualitative method. Data collection techniques and observations that researchers use include observation by observing and recording activities carried out by the journalistic division of Lensa Manduta and interviews with the head of the journalistic division and the general chairman of Lensa Manduta. The results of this study are that the journalistic training was opened interactively, the members listened to the material presented, and were quite responsive in practice to the field. In addition, they are quite familiar with the terms in journalism, such as journals, and codes of ethics, as well as a very good understanding of news, it's just that they don't know the whole, such as the types of news consisting of hard news, soft news, and straight news.
Keywords: Journalistic training, extracurricular, writing, Lensa Manduta MAN 2 Tangerang
Pengaruh E-Leadership Kepala Sekolah terhadap Keinovatifan Guru di Madrasah Aliyah (Ma) Se-Kecamatan Pamijahan Kabupaten Bogor
Authors: Lestari Hana , Rahmawati Ima , Firdaus Anika , Ihsan Muzhir 
Published: May 2023

The purpose of this study is to determine the influence of school principal e-leadership on the innovation of teachers in MA Se-Kecamatan Pamijahan Bogor. This research uses quantitative research. The data collected in the form of numbers were analyzed by linear regression analysis. This study used a questionnaire that was non-testing in nature. The questionnaire is systematically compiled by the researcher by submitting a written statement, answered by the respondent and returned to the researcher. The questionnaire in this study is a closed questionnaire, which is a questionnaire that contains the answers given by the researcher, until a respondent can only choose one answer that suits him. The questionnaire in this study contains a series of statements, including five alternative answers, and both positive and negative statements are answered by the teacher. Based on the regression test obtained a significant value of 0.000<0.05, it can be concluded that there is a positive and significant influence between the principal's e-leadership on teacher innovation.
Keywords: E-Leadership; Inovation, Teacher
Хусусийлаштирилган ер участкаларининг мақомини белгилаш муаммолари
Authors: Рахматиллаев Жасурбек 
Published: May 2023

Ушбу мақолада хусусийлаштирилган ер участкаларининг мақомини белгилаш муаммолари, ер учаскаси хусусий мулк объекти сифатидаги мақоми, кўчмас мулкка бўлган ҳуқуқларнинг давлат рўйхатидан ўтказилиши, кўчмас мулкка бўлган ҳуқуқларнинг юзага келиши, ашёвий ҳуқуқлар, ер участкаларини сотиш ва ҳадя қилиш билан боғлиқ масала, ер участкаларнинг тоифалари билан боғлиқ муаммолари очиб берилган.
Assessing the complete blood count in Graves’ ophthalmopathy patients treated with RAI-131 in Iraq
Authors: A. Khalaf Zena , Majid Khadhem Furqan , Sabah Altaiee Marwah , I. AL-Sheakli Iman 
Published: May 2023

Introduction and Aim: Graves ophthalmopathy is one of the pandemic public health disorders in Iraq. The current investigation attempts to determine the variation in the complete total blood cells on the recovery of individuals with Graves' ophthalmopathy following low and high-dose Radioactive Iodine 131 (RI-131) exposures.

Materials and Methods: The complete blood CBC level in people with Graves' illness and healthy, normal controls were quantitatively identified using the CBC counter. Thyroid stimulating hormone was utilized to compare the recovery of ophthalmopathy patients in comparison to a control group.

Results: In comparison to healthy controls, patients with Graves' ophthalmopathy disease who received 10 mci of RAI-131 had elevated lymphocyte counts (P<0.01). After one year of therapy with antithyroid drugs, lymphocyte counts rose significantly (P<0.01). In contrast, patients treated with 10 mci of RAI-131 experienced a dramatic reduction in monocytes (P< 0.01) over the course of four months. Lymphocytes, monocytes, and platelets were significantly lower in patients with ophthalmopathy after one month of therapy with 20 mci of RAI-131 compared to controls. No significant difference in red blood cells and hemoglobin levels before and after treatment with low and high doses of RAI-131 was observed.

Conclusion: Assessment of lymphocytes, monocytes, granulocytes, and platelets levels in Graves' ophthalmopathy disease patients (GD ophthalmopathy) could be used as an effective diagnostic marker for determining the most effective dose for Graves' ophthalmopathy disease treatment.
Mavacamten (Camzyos)
Authors: CADTH  
Published: May 2023

CADTH recommends that Camzyos be reimbursed by public drug plans for the treatment of symptomatic obstructive hypertrophic cardiomyopathy (oHCM) of New York Heart Association (NYHA) class II to III in adult patients if certain conditions are met.
Camzyos should only be covered to treat patients who have a documented left ventricular ejection fraction (LVEF) of 55% or greater at rest, determined by echocardiography, a left ventricular (LV) wall thickness of 15 mm or more (or ≥ 13 mm with a family history of hypertrophic cardiomyopathy [HCM]), and a left ventricular outflow tract (LVOT) peak gradient of 50 mm Hg or greater at rest, after Valsalva maneuver, or postexercise as confirmed by echocardiography. To be eligible, patients must also experience either worsening of symptoms or echocardiographically demonstrated deterioration while taking a beta-blocker (BB) or calcium channel blocker (CCB).
Camzyos should only be reimbursed if patients are under the care of a cardiologist and if the cost of Camzyos is reduced.