bluuebunny/crossref_metadata_2025_split huggingface dataset:
ENPP1 Immunobiology as a Therapeutic Target
Authors: Ruiz-Fernández de Córdoba Borja , Martínez-Monge Rafael , Lecanda Fernando 
Published: January 2023

Abstract
ENPP1 (ecto-nucleotide pyrophosphatase/phosphodiesterase) participates in the hydrolysis of different purine nucleotides in an array of physiologic processes. However, ENPP1 is frequently overexpressed in local relapses and tumor metastases, which are associated with poor prognosis and survival in a range of solid tumors. ENPP1 promotes an immunosuppressive tumor microenvironment (TME) by tilting the balance of ATP/adenosine (Ado) in conjunction with other components (CD38, CD39/ENTPD1, and CD73/NT5E). Moreover, ENPP1 intersects with the stimulator of interferon genes (STING), impairing its robust immune response through the hydrolysis of the effector 2´,3´-cyclic GMP–AMP. Thus, ENPP1 blockade emerges as a unique target eliciting immune remodeling and leveraging the STING pathway. Several ENPP1 inhibitors have shown an immunostimulatory effect, and their combination with other therapeutic modalities, such as immune-checkpoint blockade, STING activation, DNA damage response (DDR) inhibitors, and radiotherapy (RT), represents a promising avenue to boost antitumor–immune responses and to improve current clinical outcomes in several tumors. This comprehensive review summarizes the current state of the art and opens new perspectives for novel treatment strategies.
Five plus Three for the Pancreas
Authors: Löhr J.-Matthias , Pantel Klaus 
Published: January 2023

SummaryPreneoplastic high-risk lesions in the pancreas need to be differentiated from low-risk lesions warranting surveillance and eventually surgical intervention. Imaging is used so far; however, certain imaging features are subject to interpretation and hence have their intrinsic flaws. In a recent article, a liquid biopsy with protein and RNA markers demonstrates differentiation based on a blood test.See related article by Zhang et al., p. 1535
Trends and Factors Associated with Fecal Occult Blood Test Utilization among Hispanic Adults in Puerto Rico and the United States: BRFSS 2012–2020
Authors: Castaneda-Avila Maira A. , Oyinbo Atinuke G. , Epstein Mara M. , Ortiz-Ortiz Karen J. , Tortolero-Luna Guillermo , Lapane Kate L. 
Published: January 2023

AbstractIdentifying factors associated with colorectal cancer screening utilization is important to guide colorectal cancer prevention and control programs. We evaluated trends and factors associated with previous-year fecal occult blood test (FOBT) use among Hispanic adults living in Puerto Rico and the U.S. mainland. Using data from the Behavioral Risk Factor Surveillance System (2012–2020), trends in FOBT use were analyzed using joinpoint regression to estimate annual percentage change (APC). Logistic regression stratified by location identified factors associated with FOBT use. FOBT was more common among Hispanic adults ages 50 to 75 years living in Puerto Rico than in the U.S. mainland [Puerto Rico: 20.5%[2012] to 45.6%[2020], APC = 11.4%; U.S. mainland: 9.9%[2012] to 16.7%[2020], APC = 5.9%]. Factors inversely associated with FOBT use were similar in Puerto Rico and the U.S. mainland, including lack of health insurance, not having a personal doctor, having a checkup &gt;12 months ago, and not being able to see a doctor due to cost, as were factors associated with higher FOBT use, including older age, retirement, or having two or more chronic diseases. Among Hispanics living in the U.S. mainland, lack of exercise and less education were inversely associated with FOBT. Factors related to poor access to healthcare were associated with lower use of FOBT among Hispanics. Efforts to improve colorectal cancer screening in Hispanics are necessary to address health disparities across the colorectal cancer care continuum.Prevention Relevance:Colorectal cancer screening reduces cancer incidence and mortality. All screening modalities, including less invasive FOBT tests, are underutilized, especially in non-White and low-income populations. Evaluation of trends and factors associated with the increase in the use of colorectal cancer screening can inform programs to address the lack of screening among racial minorities.
Optimized design of an extreme low power datalogger for photovoltaic panels
Authors: Merabtane Bilal , Benabadji Noureddine 
Published: January 2023

<span lang="EN-US">The paper focuses on the design and implementation of a low cost and compact data logger prototype using an extreme low power (XLP) and low pin count programmable interface controllers (PIC) microcontroller using its own flash memory for the periodic data acquisition storage, while many other works focus in the Arduino Eco-system. It is planned to pick four important analog measures from the photovoltaic system, and store them directly as 10-bit numerical counts, this yields to faster data acquisition and storage (no time consuming for mathematical computation to convert each numerical count of raw data to meaningful real-world data). Avoiding the use of any kind of display and keypad, and keeping the ratio run time over sleep time as low as possible, has a maximum impact on lowering the power consumption. This prototype can be serially linked to a personal computer (PC) to view the acquisition of measurements in real time, and to retrieve all collected data through a terminal application. The experimental results are stored in comma-separated values (CSV) files to ease post data analysis with any spread sheet software, for statistical calculations and graphs drawing, in order for instance, to find the faults of the photovoltaic system and optimize its management and its performance.</span>
Parkinson’s diagnosis hybrid system based on deep learning classification with imbalanced dataset
Authors: Ouhmida Asmae , Raihani Abdelhadi , Cherradi Bouchaib , Sandabad Sara 
Published: January 2023

<span lang="EN-US">Brain degeneration involves several neurological troubles such as Parkinson’s disease (PD). Since this neurodegenerative disorder has no known cure, early detection has a paramount role in improving the patient’s life. Research has shown that voice disorder is one of the first symptoms detected. The application of deep learning techniques to data extracted from voice allows the production of a diagnostic support system for the Parkinson’s disease detection. In this work, we adopted the synthetic minority oversampling technique (SMOTE) technique to solve the imbalanced class problems. We performed feature selection, relying on the Chi-square feature technique to choose the most significant attributes. We opted for three deep learning classifiers, which are long-short term memory (LSTM), bidirectional LSTM (Bi-LSTM), and deep-LSTM (D-LSTM). After tuning the parameters by selecting different options, the experiment results show that the D-LSTM technique outperformed the LSTM and Bi-LSTM ones. It yielded the best score for both the imbalanced original dataset and for the balanced dataset with accuracy scores of 94.87% and 97.44%, respectively.</span>
K-means variations analysis for translation of English Tafseer Al-Quran text
Authors: Ahmed Mohammed A. , Baharin Hanif , Ellyza Nohuddin Puteri Nor 
Published: January 2023

Text mining is a powerful modern technique used to obtain interesting information from huge datasets. Text clustering is used to distinguish between documents that have the same themes or topics. The absence of the datasets ground truth enforces the use of clustering (unsupervised learning) rather than others, such as classification (supervised learning). The “no free lunch” (NFL) theorem supposed that no algorithm outperformed the other in a variety of conditions (several datasets). This study aims to analyze the k-means cluster algorithm variations (three algorithms (k-means, mini-batch k-means, and k-medoids) at the clustering process stage. Six datasets were used/analyzed in chapter Al-Baqarah English translation (text) of 286 verses at the preprocessing stage. Moreover, feature selection used the term frequency–inverse document frequency (TF-IDF) to get the weighting term. At the final stage, five internal cluster validations metrics were implemented silhouette coefficient (SC), Calinski-Harabasz index (CHI), C-index (CI), Dunn’s indices (DI) and Davies Bouldin index (DBI) and regarding execution time (ET). The experiments proved that k-medoids outperformed the other two algorithms in terms of ET only. In contrast, no algorithm is superior to the other in terms of the clustering process for the six datasets, which confirms the NFL theorem assumption.
A review of hyperspectral imaging-based plastic waste detection state-of-the-arts
Authors: Tamin Owen , Moung Ervin Gubin , Dargham Jamal Ahmad , Yahya Farashazillah , Omatu Sigeru 
Published: January 2023

<span lang="EN-US">Plastic waste issues emerged from the build-up of plastics that negatively impacts the environment. As a result, plastic waste detection is proposed in many research studies to tackle the problems. Therefore, this paper aims to review hyperspectral imaging techniques and machine learning in plastic waste detection. Hyperspectral imaging techniques are found to be effective in detecting plastic waste and microplastics as they were able to capture plastic reflectance spectral by using the near-infrared sensor. However, the review also shows that hyperspectral imaging techniques were less efficient in capturing the electromagnetic spectrum of black plastics due to carbon-black absorption properties. Carbon-black strongly absorbs light in the ultraviolet and infrared spectral range of the electromagnetic spectrum, therefore not detected by the near-infrared sensor. This paper also reviews how machine learning can alternatively detect and sort all types of waste, including plastics. Multiple studies show that the machine learning model achieved good accuracy in detecting all types of plastics based on the waste dataset. Finally, it can be seen that the spectral information of plastic can be used as feature extraction for machine learning models for better plastic detection. It is hoped that this study will contribute to more systematic research on the same topic.</span>
Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice—Brief Report
Authors: Ward Soracha E. , Guest Thomas , Byrne Ciara , Lopes Patricia , O’Sullivan Jamie M. , Doherty Dearbhla , O’Connell David , Gutierrez Llaneza Sara , Chion Alain , Fazavana Judicael , Fallon Padraic G. , Preston Roger J.S. , Johnsen Jill M. , Pipe Steven W. , Turecek Peter L. , O’Donnell James S. ,   on behalf of the iPATH Study Group
Published: February 2023

Background:
Although most plasma FVIII (Factor VIII) circulates in complex with VWF (von Willebrand factor), a minority (3%–5%) circulates as free-FVIII, which is rapidly cleared. Consequently, 20% of total FVIII may be cleared as free-FVIII. Critically, the mechanisms of free-FVIII clearance remain poorly understood. However, recent studies have implicated the MGL (macrophage galactose lectin) in modulating VWF clearance.

Methods:

Since VWF and FVIII share similar glycosylation, we investigated the role of MGL in FVIII clearance. FVIII binding to MGL was assessed in immunosorbent and cell-based assays. In vivo, FVIII clearance was assessed in

MGL1
−/−

and

VWF
−/−

/FVIII
−/−

mice.

Results:

In vitro–binding studies identified MGL as a novel macrophage receptor that binds free-FVIII in a glycan-dependent manner.

MGL1
−/−

and

MGL1
−/−

mice who received an anti-MGL1/2 blocking antibody both showed significantly increased endogenous FVIII activity compared with wild-type mice (
P
=0.036 and
P
<0.0001, respectively). MGL inhibition also prolonged the half-life of infused FVIII in

FVIII
−/−

mice. To assess whether MGL plays a role in the clearance of free FVIII in a VWF-independent manner, in vivo clearance experiments were repeated in dual

VWF
−/−

/FVIII
−/−

mice. Importantly, the rapid clearance of free FVIII in

VWF
−/−

/FVIII
−/−

mice was significantly (
P
=0.012) prolonged in the presence of anti-MGL1/2 antibodies. Finally, endogenous plasma FVIII levels in

VWF
−/−

mice were significantly increased following MGL inhibition (
P
=0.016).

Conclusions:
Cumulatively, these findings demonstrate that MGL plays an important role in regulating macrophage-mediated clearance of both VWF-bound FVIII and free-FVIII in vivo. We propose that this novel FVIII clearance pathway may be of particular clinical importance in patients with type 2N or type 3 Von Willebrand disease.
Precise Metabolomics Defines Systemic Metabolic Dysregulation Distinct to Acute Myocardial Infarction Associated With Diabetes
Authors: Xia Jing-gang , Li Bowen , Zhang Hao , Li Qin-xue , Lam Sin Man , Yin Chun-lin , Tian He , Shui Guanghou 
Published: February 2023

Background:
Acute myocardial infarction (AMI) is a leading cause of death and disability. Diabetes is an important risk factor and a common comorbidity in AMI patients. The higher mortality risk of diabetes-AMI relative to nondiabetes-AMI indicates a need for specific treatment to improve clinical outcome. However, the global metabolic dysregulation of AMI complicated with diabetes is still unclear. We aim to systematically interrogate changes in the metabolic microenvironment immediate to AMI episodes in the absence or presence of diabetes.

Methods:
In this work, quantitative metabolomics was used to investigate plasma metabolic differences between diabetes-AMI (n=59) and nondiabetes-AMI (n=59) patients. A diverse array of perturbed metabolic pathways involving carbohydrate metabolism, lipid metabolism, glycolysis, tricarboxylic acid cycle, and amino acid metabolism emerged.

Results:
In all, our omics-oriented approach defined a metabolic signature of afflicted mitochondrial function aggravated by concurrent diabetes in AMI patients. In particular, our analyses uncovered N-lactoyl-phenylalanine and lysophosphatidylcholines as key functional metabolites that skewed the metabolic picture of diabetes-AMI relative to nondiabetes-AMI. N-lactoyl-phenylalanine was strongly associated with metabolic indicators reflective of mitochondrial overload and negatively correlated with HbA1c (glycosylated hemoglobin, type A1C) specifically in hyperglycemic AMI, suggestive of its central role in glucose utilization and mitochondrial energy production instrumental to the clinical outcome of diabetes-AMI. Reductions in lysophosphatidylcholines, which were negatively correlated with blood glucose and inflammatory markers, might further compromise glucose expenditure and aggravate inflammation leading to poorer prognosis in diabetes-AMI.

Conclusions:
As circulating metabolite levels are amenable to therapeutic intervention, such shifts in metabolic signatures provide new clues and potential therapeutic targets specific to the treatment of diabetes-AMI.
Predictors of Improvement in Exercise Tolerance After Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
Authors: Daigo Kyohei , Katsumata Yoshinori , Esaki Kosho , Iwasawa Yuji , Ichihara Genki , Miura Kotaro , Shirakawa Kohsuke , Sato Yasunori , Sato Kazuki , Fukuda Keiichi 
Published: January 2023

Background
Balloon pulmonary angioplasty (BPA) improves exercise tolerance and hemodynamic parameters in patients with chronic thromboembolic pulmonary hypertension. However, it is still unclear which patient characteristics contribute to the improvement in exercise tolerance after BPA in chronic thromboembolic pulmonary hypertension.

Methods and Results

We retrospectively analyzed 126 patients with chronic thromboembolic pulmonary hypertension (aged 63±14 years; female, 65%) who underwent BPA without concomitant programmed exercise rehabilitation at Keio University between November 2012 and April 2018. Hemodynamic data and 6‐minute walk distance (6MWD), as a measure of exercise tolerance, were evaluated before and 1 year after BPA. The clinical characteristics that contributed to improvement in exercise tolerance were elucidated. The 6MWD significantly increased from 372.0 m (256.5–431.3) to 462.0 m (378.8–537.0) 1 year after BPA (
P
<0.001). The improvement rate in the 6MWD after BPA exhibited a good correlation with age, height, mean pulmonary artery pressure, and 6MWD at baseline (Spearman rank correlation coefficients=−0.28, 0.24, −0.40, and 0.44, respectively). Additional multivariable linear regression analysis revealed that young age, tall height, high mean pulmonary artery pressure, short 6MWD at baseline, and high lung capacity at baseline were significant predictors of the improvement in 6MWD by BPA (standardized partial regression coefficient −0.39, 0.22, 0.19, −0.62, and 0.25,
P
<0.001, 0.007, 0.011, <0.001, and <0.001, respectively).

Conclusions
BPA without concomitant programmed exercise rehabilitation significantly improves exercise tolerance. This was particularly true in young patients with high stature, high mean pulmonary artery pressure, short 6MWD, and lung capacity at the time of diagnosis.
Health Status Outcomes in Older Adults Undergoing Chronic Total Occlusion Percutaneous Coronary Intervention
Authors: Nguyen Dan D. , Gosch Kensey L. , El‐Zein Rayan , Chan Paul S. , Lombardi William L. , Karmpaliotis Dimitri , Spertus John A. , Wyman R. Michael , Nicholson William J. , Moses Jeffrey W. , Grantham J. Aaron , Salisbury Adam C. , Grantham J. Aaron , Cook Stephen L. , Doshi Parag , Federici Robert , Karmpaliotis Dmitri , Lombardi William L. , Moses Jeffrey W. , Nicholson William J. , Pershad Ashish , Spaedy Anthony J. , Wyman R. Michael 
Published: January 2023

Background
Although chronic total occlusions (CTOs) are common in older adults, they are less likely to be offered CTO percutaneous coronary intervention for angina relief than younger adults. The health status impact of CTO percutaneous coronary intervention in adults aged ≥75 years has not been studied. We sought to compare technical success rates and angina‐related health status outcomes at 12 months between adults aged ≥75 and <75 years in the OPEN‐CTO (Outcomes, Patient Health Status, and Efficiency in Chronic Total Occlusion) registry.

Methods and Results

Angina‐related health status was assessed with the Seattle Angina Questionnaire (score range 0–100, higher scores denote less angina). Technical success rates were compared using hierarchical modified Poisson regression, and 12‐month health status was compared using hierarchical multivariable linear regression between adults aged ≥75 and <75 years. Among 1000 participants, 19.8% were ≥75 years with a mean age of 79.5±4.1 years. Age ≥75 years was associated with a lower likelihood of technical success (adjusted risk ratio=0.92 [95% CI, 0.86–0.99;
P
=0.02]) and numerically higher rates of in‐hospital major adverse cardiovascular events (9.1% versus 5.9%,
P
=0.10). There was no difference in Seattle Angina Questionnaire Summary Score at 12 months between adults aged ≥75 and <75 years (adjusted difference=0.9 [95% CI, −1.4 to 3.1;
P
=0.44]).

Conclusions
Despite modestly lower success rates and higher complication rates, adults aged ≥75 years experienced angina‐related health status benefits after CTO‐percutaneous coronary intervention that were similar in magnitude to adults aged <75 years. CTO percutaneous coronary intervention should not be withheld based on age alone in otherwise appropriate candidates.
Derivation and Validation of an Algorithm to Detect Stroke Using Arm Accelerometry Data
Authors: Messé Steven R. , Kasner Scott E. , Cucchiara Brett L. , McGarvey Michael L. , Cummings Stephanie , Acker Michael A. , Desai Nimesh , Atluri Pavan , Wang Grace J. , Jackson Benjamin M. , Weimer James 
Published: January 2023

Background
Early diagnosis is essential for effective stroke therapy. Strokes in hospitalized patients are associated with worse outcomes compared with strokes in the community. We derived and validated an algorithm to identify strokes by monitoring upper limb movements in hospitalized patients.

Methods and Results
A prospective case–control study in hospitalized patients evaluated bilateral arm accelerometry from patients with acute stroke with lateralized weakness and controls without stroke. We derived a stroke classifier algorithm from 123 controls and 77 acute stroke cases and then validated the performance in a separate cohort of 167 controls and 33 acute strokes, measuring false alarm rates in nonstroke controls and time to detection in stroke cases. Faster detection time was associated with more false alarms. With a median false alarm rate among nonstroke controls of 3.6 (interquartile range [IQR], 2.1–5.0) alarms per patient per day, the median time to detection was 15.0 (IQR, 8.0–73.5) minutes. A median false alarm rate of 1.1 (IQR. 0–2.2) per patient per day was associated with a median time to stroke detection of 29.0 (IQR, 11.0–58.0) minutes. There were no differences in algorithm performance for subgroups dichotomized by age, sex, race, handedness, nondominant hemisphere involvement, intensive care unit versus ward, or daytime versus nighttime.

Conclusions
Arm movement data can be used to detect asymmetry indicative of stroke in hospitalized patients with a low false alarm rate. Additional studies are needed to demonstrate clinical usefulness.
Different Changing Patterns for Stroke Subtype Mortality Attributable to High Sodium Intake in China During 1990 to 2019
Authors: Wang Yan , Wang Jingyu , Chen Shufeng , Li Bingbing , Lu Xiangfeng , Li Jianxin 
Published: February 2023

Background:
It is unclear whether sodium intake had similar effects on mortality of stroke subtypes. The purpose of this study is to compare the long-term trends in mortality of stroke subtypes attributable to high sodium intake in China during 1990 to 2019.

Methods:
Data for China in the GBD (Global Burden of Disease) 2019 study were obtained mainly from the Chinese surveillance systems and the KaiLuan Study. The trends in stroke mortality due to high sodium intake (>5 g/d) were evaluated using join-point regression and age-period-cohort methods adjusting for age, period, and cohort.

Results:
The age-standardized mortality rates of stroke attributable to high sodium intake showed downward trends during 1990 to 2019 in China, with an average annual percentage change of −0.6 (95% CI, −0.8 to −0.4) for ischemic stroke, −2.5 (95% CI, −2.8 to −2.2) for intracerebral hemorrhage, and −6.1 (95% CI, −6.6 to −5.7) for subarachnoid hemorrhage. The curves of local drifts, which reflected the average annual percentage change of stroke mortality due to high sodium intake across age groups, showed a slow upward trend with age for ischemic stroke, a slow downward trend for intracerebral hemorrhage, and a sharp downward trend for subarachnoid hemorrhage. The high sodium–related mortality increased dramatically with age for ischemic stroke and intracerebral hemorrhage, while it reached a peak at 50 to 70 years old for subarachnoid hemorrhage. The period and cohort rate ratios of stroke mortality due to high sodium intake decreased in the past 3 decades, with the greatest decline for subarachnoid hemorrhage and the weakest decrease for ischemic stroke. Notably, men had higher high sodium–related mortality and risk but slighter declines for all stroke subtypes than women.

Conclusions:
Our results provided powerful evidence that high sodium–related age-standardized mortality rates and risk of stroke in China decreased in the past 3 decades, with diverse changing patterns for different stroke subtypes, highlighting that salt reduction had distinct impact on stroke subtypes.