bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASPECTS OF QUALITY OF LIFE IMPACTED ON PATIENTS WITH PROLONGED COVID-19 SYMPTOMS (LONG COVID)
Authors: Puspita Nanda , Quentin De Queen Mcgiani Honey 
Published: September 2023

Background: A subset of patients diagnosed with COVID-19 is encountering persistent post-COVID symptoms. These symptoms can significantly impede their quality of life and exert profound effects on their day-to-day functioning. Purpose: This study aimed to identify the dimensions of quality of life most affected in patients with long COVID symptoms. Methods: A cross-sectional survey was applied using the SF-36 questionnaire which was distributed on Twitter and Instagram. Furthermore, a total of 122 respondents were obtained through accidental sampling. The association between variables was analyzed using Chi-square and Mann-Whitney tests. Results: Respondents who completed the questionnaire (n=122) came from different regions, with West Java as the largest area of origin (37.70%). In addition, the majority were female (n=103, 84.4%) under 25 years old (n=92, 75.41%), and the three symptoms experienced were fatigue (n=108; 35.29%), brain fog (n=61;19.93%), and olfactory disturbances (n=54; 17.65%). There was an association between long COVID duration and gender (p= 0.03). However, there was no association between other demographic characteristics with long COVID duration (p > 0.05). General health (41.67 (IQR=29), p= 0.00) and vitality (40.00 (IQR=20), p= 0.02) were the two aspects of quality of life significantly altered in patients with long COVID symptoms more than 3 months. Conclusion: The aspects of quality of life, particularly general health and vitality, experienced a significant decline in post-COVID-19 patients with long COVID symptoms for more than 3 months.
Hubungan antara Kepercayaan Diri dengan Komunikasi Interpersonal Siswa
Authors: Damayanti Natasya Meilina , Kholili Ma'rifatin Indah , Dewantoro Adi 
Published: September 2023

<p>The aims of this research are: Describe the level of self-confidence, interpersonal communication skills and analyze the relationship of self- confidence with the interpersonal communication of second grade students of SMA Negeri 1 Karanganyar. This research is quantitative research with correlational methods. The population is second grade students of SMA Negeri 1 Karanganyar with a total population of 431 people. The sampling technique is simple random sampling. Sampling was carried out using the Slovin formula which was then obtained from a research sample of 207 people with details of 17-18 people per class. The research instruments are self-confidence scale and interpersonal communication skills scale. The answer choices use the likert scale with 4 answer choices and analyzed using Product Moment Correlation in SPSS. The results of study obtained that students with low communication skills were 17%, medium at 63%, and high at 20%. While the coefficient value of 0.397 with a sig value of 0.000, which means if it is 0.000 &lt; 0.05 then the confidence variable and the interpersonal communication variable have a relationship. The two have a positive relationship, it means when the level of self-confidence is high, the student's interpersonal communication are also high.</p>
Studi Kepustakaan Penerapan Solution-Focused Brief Therapy (SFBT) dalam Bimbingan dan Konseling
Authors: Nirmala Yudith Trisna , Susilo Agus Tri , Suryawati Citra Tectona 
Published: September 2023

The purpose of this research is to examine the application of SFBT which includes the objectives, scope, procedures, and the success of its application in guidance and counseling. The research method used is literature review. The data source used is how many 20 research journals that show a connection with the problem to be studied. The data collection technique used is documentation. The data analysis technique used is content analysis. The results of this study are: (1) The target of application of SFBT is school age students who are classified as children and adolescents, (2) Scope of application of SFBT the environmental space is in the form of personal, social emotional, behavioral, and academic problems, (3) The methods / techniques for applying SFBT include <em>exceptional questions</em>, <em>miracle</em> <em>questions</em>, <em>scaling</em> <em>questions </em>(4) The procedure for implementing SFBT consists of 3 main stages, (5) The successful implementation of SFBT, namely is effectively capable and successful in reducing aggressive behavior, increasing perceptions of social competence, self-perception, sense of coherence, self-esteem, self-efficacy, self-regulation, reducing symptoms of depression, overcoming burnout, self-concept, managing academic stress, overcoming addiction internet, self-adjustment, understanding the problems faced, helping in understanding student needs, controlling compulsive internet use, decreasing academic procrastination behavior.
Pengaruh Model Think Talk Write Berbantuan Media Gambar Seri Terhadap Keterampilan Menulis Teks Ekposisi Siswa Kelas VIII SMP Negeri 2 Kedungadem Kabupaten Bojonegoro
Authors: Andriani Devi Novia , Syarifudin Albitar Septian 
Published: September 2023

Penelitian ini dilakukan berdasarkan permasalahan yang dialami oleh siswa yang masih kesulitan dalam mengungkapkan ide, pokok pikiran, pendapat, informasi. Tujuan penelitian ini adalah untuk mengetahui pengaruh model Think Talk Write berbantuan media gambar seri terhadap keterampilan menulis teks eksposisi siswa kelas VIII SMP Negeri 2 Kedungadem Kabupaten Bojonegoro. Penelitian ini merupakan penelitian kuantitatif model eksperimen menggunakan desain Quasi Experimental Design dengan bentuk Nonequivalent Control Group Design. Teknik pengumpulan data dilakukan dengan memberikan tes awal (pretest), kemudian diberi perlakuan (treatment) dengan menerapkan model Think Talk Write berbantuan media gambar seri dan selanjutnya diberikan tes terakhir (posttest) pada akhir pembelajaran di kelas eksperimen. Hasil penelitian adalah penerapan model Think Talk Write berbantuan media gambar seri pada keterampilan menulis teks eksposisi bertema lingkungan pada siswa kelas VIII SMP Negeri 2 Kedungadem Kabupaten Bojonegoro, dengan hasil uji hipotesis (uji t) menggunakan taraf signifikan 0,05 diperoleh hasil t-hitung 4,056 t-tabel 1,67739 yang berarti Ho ditolak dan Ha diterima yang artinya terdapat pengaruh yang signifikan antara model Think Talk Write berbantuan media gambar seri dengan keterampilan menulis teks eksposisi siswa kelas VIII SMP Negeri 2 Kedungadem Kabupaten Bojonegoro.
Pengaruh Penggunaan Media Poster Terhadap Keterampilan Menulis Puisi Siswa Kelas VIII MTS Darul Hikmah Mojokerto
Authors: Hamidah Nadia Hasna , Kayati Afiyah Nur 
Published: September 2023

Penelitian ini dilatarbelakangi oleh kurangnya kemampuan siswa dalam menulis puisi. Perlu menerapkan media pembelajaran yaitu media poster untuk mengurangi lemahnya kemampuan siswa dalam menulis. Tujuan penelitian yaitu mengetahui pengaruh media poster terhadap keterampilan menulis puisi siswa kelas VIII MTS Darul Hikmah Mojokerto. Penelitian ini menggunakan metode penelitian kuantitatif quasi experimental dengan desain nonequivalent control design group. Teknik pengambilan sampel menggunakan sampling purposive. Sampel yang digunakan pada penelitian adalah Penelitian ini menggunakan sampel kelas VIII A sebagai kelas kontrol dan VIII B sebagai kelas eksperimen. Teknik pengumpulan data yang digunakan adalah tes, angket, wawancara, dan lembar observasi. Instrumen penelitian dalam penelitian ini adalah tes, angket, wawancara, dan lembar observasi. Uji prasyarat pada penelitian menggunakan uji homogenitas, uji normalitas dan Uji T. Dalam perhitungan uji homogenitas posttest 0,97 1,92 dan uji homogenitas pretest 1,70 1,92 dapat dikategorikan homogen. Pada perhitungan uji normalitas pretest kelas eksperimen 0,093 0,224 dan uji normalitas posttest kelas eksperimen 0,154 0,224. Sedangkan, uji normalitas pretest kelas kontrol 0,105 0,224 dan uji normalitas posttest kelas kontrol 0,153 0,224 dari perhitungan uji normalitas dapat dikategorikan berdistribusi normal. Pada perhitungan Uji T diperoleh Thitung (4,424) Ttabel (2,042) sehingga Ho ditolak dan Ha diterima. Berdasarkan hasil perhitungan uji prasyarat bahwa adanya pengaruh penggunaan media poster dalam keterampilan menulis puisi. Dengan demikian, guru diberikan saran untuk memanfaatkan media poster pada keterampilan menulis puisi.
Pengaruh Model Pembelajaran Brainwriting Berbantuan Media Video Animasi “Produk Lokal” Terhadap Keterampilan Menulis Teks Persuasi Siswa Kelas VIII SMP Miftahul Ulum Melirang
Authors: Silvianita Azimatus , Kayati Afiyah Nur 
Published: September 2023

Penelitian ini bertujuan untuk mengetahui keterampilan menulis teks persuasi sebelum dan setelah penerapan model pembelajarn brainwriting, setelah mengetahui pengaruh model pembelajaran brainwriting berbantuan media video animasi “Produk Lokal” terhadap keterampilan menulis teks persuasi siswa. Penelitian ini menggunakan pendekatan kuantitatif berjenis Quasi Experimental Design dalam bentuk Non-Equivalent Control Design. Proses pengambilam sampel menggunakan teknik sampling jenuh. Sampel yang digunakan yakni kelas VIII-A sebagai kelas eksperimen dan kelas VIII-B sebagai kelas kontrol. Pada uji normalitas diperoleh hasil pretest kelas eksperimen 0,260 0,294 dan uji normalitas hasil post-test diperoleh 0,243 0,294 sedangkan uji normalitas kelas kontrol pretest diperoleh 0,150 0,294 dan hasil post-test diperoleh 0,160 0,294, dari perhitungan normalitas dapat dikategorikan berdistribusi normal. Dalam uji homogenitas pretest 1,950 2,168 dan uji post-test 1,815 2,168 dapat dikategorikan homogen. Hasil uji T diperoleh
Identification of Key Biomarkers in RF-negative Polyarticular and Oligoarticular juvenile idiopathic arthritis by Bioinformatic Analysis
Authors: liu yun , tang xuemei 
Published: September 2023

Abstract
Objective
Juvenile idiopathic arthritis (JIA) is a broad term used to describe arthritis of unknown origin. JIA commonly persists into adulthood, often causing substantial morbidity, such as restricted joint function, which can lead to challenges in employment and independence. This study aims to identify diagnostic biomarkers and investigate the role of immune cells in the pathogenesis of rheumatoid factor-negative polyarticular juvenile idiopathic arthritis (RF-negative pJIA) and oligoarticular juvenile idiopathic arthritis (oJIA).
Methods
We retrieved a JIA dataset from the GEO database and conducted an analysis of differentially expressed genes (DEGs). Subsequently, functional enrichment analysis was performed on the DEGs. Weighted gene coexpression network analysis (WGCNA) was utilized to identify key modules. Additionally, we constructed a protein‒protein interaction network to identify hub genes that serve as signature genes. Furthermore, we employed CIBERSORT to classify immune cell infiltration.
Result
s From the GSE20307 dataset, we identified a total of 1438 DEGs in RF-negative pJIA and 688 DEGs in oJIA. WGCNA clustered the data into 6 modules in pJIA and 4 modules in oJIA. Notably, the ME5 and ME2 modules exhibited significant associations with pJIA and oJIA, respectively. In both pJIA and oJIA, we identified six hub genes, four of which demonstrated high diagnostic sensitivity and specificity in pJIA, while five showed high diagnostic sensitivity and specificity in oJIA. CIBERSORT analysis suggested the potential involvement of these signature genes in immune cell infiltration.
Conclusion
In this study, we identified JUN, CXCL8, SOCS3, and KRAS as biomarkers for RF-negative pJIA and JUN, CXCL8, SOCS3, PTGS2, and NFKBIA as biomarkers for oJIA. Furthermore, our findings suggest that Tfh cells may play a role in the early onset of both RF-negative pJIA and oJIA.
Ruminant farmers’ measures for tackling the impacts of climate change on herd health in Anambra State, Nigeria
Authors: Nwobodo Cynthia Ebere , ANIEKE Chinyere Annastacia , Okoronkwo David John , Iwuchuwu Juliana Chinasa , OHAGWU Violet Amarachukwu , Udoye Charles Ekene , Ozioko Remigius Ikechukwu , IHEANYICHUKWU Miracle Onyinyechi 
Published: September 2023

Abstract
Globally, increasing morbidity and mortality in farm animals have been linked to climate change. In developing countries which are already overwhelmed by institutional inefficiencies, tackling the impacts of climate change on herd health has become a great concern. This is because, ensuring herd health is quintessential to food security, food safety and sustainable livelihoods under extreme climatic events and environmental uncertainties. Anambra State has been experiencing persistent climate anomalies especially increasing spates of destructive flooding and erosion. These not only impact humans directly but also the health and welfare of farm animals thereby jeopardizing food security. The study assessed measures taken by ruminant farmers in tackling the impact of climate change on herd health in Enugu State Nigeria. One hundred and twenty respondents were sampled. Descriptive (percentage, mean scores), and inferential statistics (regression) were used in data analysis. From the results, all (100%) of the respondents were adapting to the impacts. The effective adaptation practices were provision of shade (x̄ = 3.95; SD = 0.315), increased water intake (x̄ = 3.88; SD = 0.487), providing bedding material during cold (x̄ = 3.87; SD = 0.459) among others. There are challenges encountered in taking the measures including: poor awareness of effective adaptation practices (x̄ = 3.91; SD = 0.343), inadequate extension services (x̄ = 3.89; 0.464), inadequate finance (x̄ = 3.84; SD = 0.485) among others. Agricultural extension should emphasize sustainable ruminant production which ensures that production systems do not further entrench climate change Efforts should be intensified at providing extension agents with relevant information on effective herd health management strategies under the changing climate. Alternative ruminant species could be adopted. Climate change frontliners should prioritize appropriate financing mechanisms for ruminant farmers.
Long read sequencing characterises a novel structural variant, revealing underactive AKR1C1 with overactive AKR1C2 as a possible cause of unexplained severe fatigue
Authors: Oakley Julia , Hill Martin , Giess Adam , Tanguy Mélanie , Elgar Greg 
Published: September 2023

Abstract
Background
Causative genetic variants cannot yet be found for many disorders with a clear heritable component, including chronic fatigue disorders like myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). These conditions may involve genes in difficult-to-align genomic regions that are refractory to short read approaches. Structural variants in these regions can be particularly hard to detect or define with short reads, yet may account for a significant number of cases. Long read sequencing can overcome these difficulties but so far little data is available regarding the specific analytical challenges inherent in such regions, which need to be taken into account to ensure that variants are correctly identified. Research into chronic fatigue disorders faces the additional challenge that the heterogeneous patient population likely encompasses multiple aetiologies with overlapping symptoms, rather than a single disease entity, such that each individual abnormality may lack statistical significance within a larger sample. Better delineation of patient subgroups is needed to target research and treatment.

Methods
We use nanopore sequencing in a case of unexplained severe fatigue to identify and fully characterise a large inversion in a highly homologous region spanning the AKR1C gene locus, which was indicated but could not be resolved by short-read sequencing. We then use GC-MS/MS serum steroid analysis to investigate the functional consequences.

Results
Several commonly used bioinformatics tools are confounded by the homology but a combined approach including visual inspection allows the variant to be accurately resolved. The DNA inversion appears to increase the expression of AKR1C2 while limiting AKR1C1 activity, resulting in a relative increase of inhibitory neurosteroids and impaired progesterone metabolism.

Conclusions
This study provides an example of how long read sequencing can improve diagnostic yield in research and clinical care, and highlights some of the analytical challenges presented by regions containing tandem arrays of genes. It also proposes a novel gene associated with a specific disease aetiology that may be an underlying cause of complex chronic fatigue and possibly other conditions too. It reveals biomarkers that could be assessed in a larger cohort, potentially identifying a subset of patients who might respond to treatments suggested by the aetiology.
Weight Loss of Semaglutide Treatment for Patients With Overweight or Obesity: A Retrospective Observational Study in China
Authors: Zhang Xin-Hao , Wu Ai-Xin , Yang Zhi-Cheng , Sun Kin-Weng , Yang Ting , Wang Nan-Song , Zhang Jian-Ping 
Published: September 2023

Abstract
Background
Real-world studies on semaglutide's effect on weight loss had been largely focused on patient with type 2 diabetes, this study aim to assess the effectiveness of semaglutide in patients with overweight or obesity.
Methods
We conducted a single-center retrospective observational study and collected data on the use of semaglutide for patients with overweight or obesity with a follow-up of up to 9 months.
Results
The study included 611 patients (390 male [63.8%]; mean [SD] age, 41.3 [12.1] years; mean [SD] body weight, 88.9 [16.0]; mean [SD] BMI, 30.9 [4.2]) in the analysis at 3 months, 337 patients at 6months and 105 patients at 9 months. After 3, 6, and 9 months, the mean (SD) weight loss was 4.0 (3.7), 5.1 (4.5), and 6.3 (5.4) kg, respectively, equivalent to 4.5% (4.7%), 5.6% (4.7%), and 7.0% (5.8%), respectively (P < 0.001 for all). Patients with type 2 diabetes had a lower mean (SD) percentage weight loss at 3, 6, and 9 months compared with those without type 2 diabetes: 3.7% (3.1%) vs 5.4% (4.7%) at 3 months (P＜0.05), 5.0% (3.9%) vs 7.1% (4.4%) at 6 months (P＜0.05), and 5.6% (4.7%) vs 8.0% (5.4%) at 9 months (P＜0.05).
Conclusions
The results of this cohort study suggest that semaglutide was associated with weight loss similar to that seen in randomized clinical trials.
The efficacy of simple oral nutritional supplements versus usual care in postoperative patients with gastric cancer: study protocol for a multicenter, open-label, parallel, randomized controlled trial
Authors: Ueno Kohei , Nishigori Tatsuto , Tokoro Yukinari , Nakakura Akiyoshi , Tsunoda Shigeru , Hisamori Shigeo , Hashimoto Kyoichi , Kanaya Seiichiro , Hirai Kenjiro , Tanaka Eiji , Hata Hiroaki , Manaka Dai , Sakaguchi Masazumi , Kondo Masato , Kan Takatsugu , Itami Atsushi , Miki Akira , Kawamura Yuichiro , Toda Kosuke , Okabe Hiroshi , Yamamoto Michihiro , Yamashita Yoshito , Kinjo Yosuke , Kawada Hironori , Obama Kazutaka 
Published: September 2023

Abstract
Background: Oral nutritional supplement (ONS) formulations may lose their flavor because of the complex nutrients used. Many patients who undergo gastrectomy for gastric cancer cannot ingest sufficient amounts of ONS after surgery. Although the use of simpler nutrients in an ONS may improve the flavor, it is unclear if it can prevent the body weight loss (BWL) of patients with gastric cancer after surgery. This study aimed to evaluate the effects of ONS with carbohydrate and protein on BWL, muscle strength, and health-related quality of life (HRQoL).
Methods: This will be a multicenter, open-label, parallel, randomized controlled trial in patients with gastric cancer who will undergo gastrectomy. A total of 120 patients who will undergo gastrectomy will be randomly assigned to the ONS group or usual care (control) group in a 1:1 ratio. The stratification factors will be the clinical stage (I or ≥II) and surgical procedures (total gastrectomy or other procedure). In the ONS group, the patients will receive 400 kcal (400 ml)/day of ONS from postoperative day 5 to 7, and the intervention will continue postoperatively for 8 weeks. The control group patients will be given a regular diet. The primary outcome will be the percentage of BWL (%BWL) from baseline to 8 weeks postoperatively. The secondary outcomes will be muscle strength (handgrip strength), HRQoL (EORTC QLQ-C30, QLQ-OG25, EQ-5D-5L), nutritional status (hemoglobin, lymphocyte count, albumin), and dietary intake. All analyses will be performed on an intention-to-treat basis.
Discussion: This study will provide evidence showing whether or not ONS with simple nutritional ingredients can improve patient adherence and HRQoL by reducing BWL after gastrectomy. If supported by the study results, nutritional support with simple nutrients will be recommended to patients after gastrectomy for gastric cancer.
Trial registration: jRCTs051230012; Japan Registry of Clinical Trails. Registered on Apr. 13, 2023
Running Posture Optimization in the Process of Track and Field Sports Based on Biomechanical Principle
Authors: Yang Yan , Shi Bing , Huang Xianzhong 
Published: September 2023

Abstract
This paper aims to optimize the running posture of college students by using the principle of rod model in biomechanics. Based on this, through experiments and analysis, this paper studies some posture problems existing in college students' running process, and analyzes the influence these problems may have on the speed and stability of college students, and finally puts forward some solutions. In this paper, firstly, through the analysis of college students' motion images in Sports-1M data set, the movement process of college students is grasped, and a biomechanical model of college students' running posture is established. The actual running posture of college students is compared with this model. Then, in the process of comparison, the paper finds some posture defects, such as the backward landing point of footsteps, too great knee flexion and so on, which may lead to extra friction and energy loss for college students and have a great impact on their sports process. Therefore, this paper uses the image data in the data set to detect the movement state of college students, and finds that the running posture of some college students has a significant impact on their running process, so this paper makes a series of adjustments and optimizations to the running process of college students. It includes the adjustment of running posture, such as the adjustment of knee joint and elbow joint, which provides reasonable suggestions for improving the speed and stability of college students to effectively reduce the pressure on college students' knee joint and other related parts. In addition, the paper also tests the muscle electrical signals and skin reactions of college students during exercise. The results show that the optimized posture can make more effective use of muscle strength and reduce skin friction and wear during simulated running. This paper provides new ideas and examples for the optimization of college students' running posture, and also provides reference for the application and exploration of biomechanics in sports training. In addition, the paper can improve the competitive level of college students and make some contributions to the development of sports.