bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Descriptive Study on Patient Satisfaction with Waiting Time in Emergency Departments: Insights from Hospitals in the Northern Emirates
Authors: Mosleh Sultan , Hamoud Aisha R , Saeed Aisha A , Alnaqbi Hessa M , Alhouti Rayan S , Alshehhi Shamma S 
Published: September 2023

Abstract
Background: Long waiting times in emergency departments (EDs) are a challenge for healthcare systems, especially during the COVID-19 pandemic. This can have a negative impact on patient health outcomes.
Aim: This study aimed to identify factors that contribute to low satisfaction levels and long waiting times in EDs.
Methods: A quantitative cross-sectional study was conducted. Data were collected using an electronic survey distributed to patients who had visited an ED in the United Arab Emirates within the last four weeks. The survey included questions about patient satisfaction, waiting times, and perceived barriers to care.
Results: A total of 394 patients participated in the study. The overall satisfaction rate was 6.82 (SD±2.62). The highest satisfaction was with medication (78.6%), followed by discharge information (54.8%). The lowest satisfaction was with waiting times (36.7%). Most patients (56.6%) were seen by a nurse within 15 minutes, and 51.5% were seen by a doctor within 30 minutes. There was a negative association between waiting time and patient satisfaction. As the waiting time increased, satisfaction decreased. The four most common barriers to long waiting times were: computer systems (46%), crowded waiting lounges (42.7%), understaffing (38.1%), and inadequate number of examination/consultation rooms (37.3%).
Conclusion: Patient satisfaction is significantly impacted by waiting times in EDs. In order to improve patient satisfaction, hospital management should address the barriers to long waiting times that were identified in this study. Additionally, a large-scale study is needed to assess patient satisfaction and waiting times in UAE hospitals
Prevention and Control Technology of Optical Transmission Network Management being Illegally Taken over with Wireless Sensor Technology
Authors: Lin Mi , Zhang Huanyu , Liu Xiaomin , Zhang yu , Hong jie , Jiangyu Yan 
Published: September 2023

Abstract

The transmission network represented by optical fiber communication constitutes the most important basic network of modern communication. It provides transmission channels for various telecommunication service networks, dispatches and protects the transmission channels, manages the transmission network, and is an important part of the entire network management system. The efficient and centralized management of the resource objects in the network management is the basis for realizing the optical transmission integrated network management system, and it is also an important component of the entire integrated network management system. In this context, this paper studies the prevention and control technology of optical transmission network management being illegally taken over, based on wireless sensing technology. We use deep learning to monitor traffic anomalies that may occur when the network management is illegally taken over and then feed the data back to the security maintenance system to clear the anomalies. We introduce the development status of wireless sensor technology and optical transmission network management technology, which provided a theoretical basis for building network models. The related technologies and principles of DNNs are introduced, the traffic model and anomaly detection are studied, and a self-encoding and decoding anomaly detection model based on an attention mechanism is proposed. An anomaly scoring mechanism is designed on the basis of the traffic model, and an attention-based anomaly detection model is proposed. Experimental results show that the accuracy of our model reaches 95% while the recall is more than 96%, outperforming many of the existing models. The training efficacy of the model is significantly improved.
Safety Evaluation of PEGylated MNPs and p-PEGylated MNPs in SD Rats
Authors: Wen Hairuo , Huo Guitao , Qin Chao , Wu Hui , Wang Dan , Dan Mo , Geng Xingchao , Liu Shujie 
Published: September 2023

Abstract
Polyethylene glycol-coated magnetic nanoparticles (PEGylated MNPs) have demonstratedprominent advantages in cancer diagnosis and hyperthermia therapy. However, there is currently lack of standard mode and sufficient toxicity data for determining the delayed risk of PEGylated MNPs. Nevertheless, the toxicity potentials, especially those associated with the oxidative stress, were ubiquitously reported.In this study, PEGylated MNPs and p-PEGylated MNPs were administrated to SD(Sprague Dawley) rats by single intravenously injection, and various toxicity indicators were monitored till 56 days post-administration for a comprehensive toxicity evaluation.Werevealed that both nanoparticles could be rapidly cleared from plasma and enter tissues, such as, liver, kidneys and spleen, and p-PEGylatedMNP is less prone to be accumulated in the tissues, indicating a lower toxicity risk. PEGylated MNPs were more likely to up-regulate the expression levels of Th2 type cytokines and trigger inflammatory pathways, butno related pathological change was found. Both MNPs are not mutagenic, while recoverablemild DNA damage associated with the presence of nanoparticles might also be observed. This study demonstrateda research approach for the non-clinical safety evaluation of nanoparticles. It also providedcomprehensive valuable safety data for PEGylated and p-PEGylatedMNPs, for promoting the clinical application and bio-medical translation of such MNPs with PEG modifications inthe cancer diagnosis and therapy.
A clustering algorithm for UV-cooperative UAV network in dynamic scenarios
Authors: Zhao Taifei , 刘 阳 , Zhang Jianwei , Guo Jiahao 
Published: September 2023

Abstract
To address the electromagnetic interference problems faced by swarm UAVs in complex environments and the clustering needs of swarm UAV networks in dynamic scenarios, this paper proposes a weighted clustering algorithm for wireless UV cooperative swarm UAVs, which combines the advantages of UV anti-interference and high secrecy to provide a reliable communication method for swarm UAVs. By introducing adaptive node degree, UAV energy efficiency, and distance stability parameters to improve the cluster head election formula, the algorithm is made more applicable to dynamic scenarios. Simulation results show that this algorithm can improve the network survival period by 16%, while reducing the average number of cluster heads by 37% and nearly doubling the data transmission volume.
A Low Power Hybrid DCO using Three transistor (3-T) XNOR gate, CMOS and Pseudo-NMOS inverter
Authors: bagri MANJU , kumar Manoj , kumar Ramnish 
Published: September 2023

Abstract

This research article presents a comprehensive investigation of three-bit hybrid-digitally controlled ring oscillator (HDCRO) implemented with TMSC 90nm CMOS technology.The hybrid circuit HDCRO comprises of three distinct delay stages, namely XNOR-based inverter, a CMOS inverter, and a Pseudo-NMOS inverter, all of which have been designed utilizing an inversion MOS varactor (IMOS). Furthermore, the investigation explores the output frequency variation in the load element of the HDCRO by adjusting the capacitance of the digitally controlled MOS varactors. This frequency variation occurs as a result of changing the digital control bits of the MOS varactors at a supply voltage of 0.7 V. The proposed HDCRO demonstrates an oscillation frequency range of 2.558 GHz to 2.649 GHz, with power consumption varying from 3.638 mW to 1.046 mW, and phase noise from -68.070 dB@1 MHz to -67.654 dB@1 MHz relative to the central oscillation frequency. Moreover, by applying a supply voltage variation between 0.5 V and 1 V, a wider frequency tuning range of 1.238 GHz to 4.438 GHz is achieved. This extended tuning range exhibits power consumption variation from 2.785 µW to 54.66 mW, and phase noise from -68.812 dB@1 MHz to -65.445 dB@1 MHz relative to the central oscillation frequency. In summary, this study presents a novel HDCRO architecture that demonstrates excellent performance in terms of frequency range, power consumption and phase noise. The proposed design offers advantages of high speed, low-power and good frequency range; thus has a promising prospect of application in high-performance integrated circuits.
Polyunsaturated fatty acids and attention deficit hyperactivity disorder/autism spectrum disorder risk: a multivariable Mendelian randomization study
Authors: LI ZHIRUI , ZHANG QIAN , FAN ZIXUAN 
Published: September 2023

Abstract
Purpose Attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are prevalent neurodevelopmental disorders caused by genetic and environmental factors. The basic brain processes or biomarkers of novel ADHD/ASD medication targets are yet unknown. Observational studies have linked polyunsaturated fatty acids (PUFAs) to ADHD/ASD, but the causative linkages are unknown.
Methods A large genome-wide association study (GWAS) was pooled to give summary statistics on unsaturated fatty acids and ADHD/ASD utilizing a multivariate Mendelian randomization (MVMR) research design. DHA, LA, omega-3, and omega-6 fatty acids were examined in ADHD/ASD GWAS data. Inverse variance weighting (IVW) and MR-Egger and outlier point tests (MR-PRESSO) were used to evaluate data from univariate Mendelian randomization analysis of significant genetic connections with PUFA levels (P < 5 × 10-8). The odds ratio (OR) and 95% CI for MVMR analysis utilizing IVW were calculated using combinations of single nucleotide polymorphisms (SNPs) as a composite proxy for fatty acids.
Results There was some degree of causality between genetically predicted LA and both susceptibilities (ADHD, OR = 0.898, 95% CI = 0.806–0.999, P = 0.049; ASD: OR = 2.399, 95% CI = 1.228–4.688, P = 0.010). However, other PUFAs were not associated with ADHD/ASD.
Conclusion LA appears to be a substantial, independent cause of ADHD and ASD. LA may treat ADHD but worsen ASD. LA's function in ADHD and ASD needs additional longitudinal cohorts or randomized controlled studies.
Systematic review and meta-analysis of the effects of exercise on cognitive impairment and neuroprotective mechanisms in diabetes mellitus animal models
Authors: Liu Zhiyao , Huang Hailiang , Zhao Liuyang 
Published: September 2023

Abstract
This study aims to assess the effects of exercise on cognitive impairment behavioral performance and neuroprotective mechanisms in diabetes mellitus (DM) animal models. PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database (VIP), and China Biomedical Literature Database (CBM) were systematically searched for studies investigating the impact of exercise on cognitive impairment in animal models of diabetes mellitus (DM) from the inception of these databases through July 2023. Rigorous quality assessments were conducted on the included literature. Primary outcome measures comprised fasting blood glucose (FBG) levels and performance in the Morris water maze test, while secondary outcomes focused on mechanisms related to neuroprotection. Statistical analysis of outcome data was conducted using RevMan 5.3 and R software. A total of 17 studies were included, encompassing 399 animals. The results of the meta-analysis of primary outcome measures revealed that, compared to the control group, exercise effectively reduced fasting blood glucose (FBG) levels in diabetic animal models. In the Morris water maze experiment, exercise also significantly decreased the escape latency of diabetic animal models, increased the number of platform crossings, improved the percentage of time spent in the target quadrant, extended the time spent in the target quadrant, and enhanced swimming speed. Meta-analysis of secondary outcome measures indicated that exercise effectively reduced Aβ deposition, attenuated oxidative stress, enhanced synaptic function, suppressed cellular apoptosis and neuroinflammation, and promoted neurogenesis. Exercise represents a promising non-pharmacological therapy with a positive impact on diabetes-related cognitive function and neuroprotection. Moreover, this study provides a theoretical foundation for further preclinical and clinical trials.
Association between Capillaria hepatica infection-induced alterations in gut microbiota and estrogen expression in Brandt's voles (Lasiopodomys brandtii)
Authors: Hu Bin , Yue Kening , Feng Shengyong , Zhao Ning , Li Gaojian , Gao Sichao , Xing Yanan , Han Shuyi , He Hongxuan 
Published: September 2023

Abstract
Background
Capillaria hepatica, a zoonotic parasite, is present in the population of Brandt's voles (Lasiopodomys brandtii) and has been a central issue in ecological studies regarding its impact on host populations. Brandt's voles are known for their extremely high reproductive capacity, and outbreaks of Brandt's voles have occurred multiple times in the grasslands of Inner Mongolia over the past few decades. However, the mechanisms underlying the population dynamics of Brandt's voles, particularly in response to C. hepatica infection, remain poorly understood. The gut microbiota plays a crucial role in regulating hormones in the reproductive endocrine system. In this study, we investigate the role of gut microbiota in the regulation of host population dynamics in response to C. hepatica infection.
Methods
Female Brandt's voles were inoculated with eggs of infected C. hepatica, and BALB/C mice were used as a control. At the end of the experimental period, cecal contents were collected for 16S rRNA amplicon sequencing, and the expression levels of reproductive-related hormones were determined using enzyme-linked immunosorbent assay (ELISA).
Results
C. hepatica infection leads to an increased diversity of gut microbiota in Brandt's voles, with significant changes in microbial composition. The relative abundance of Muribaculaceae and Eubacteriaceae increased significantly, while that of Rikenellaceae and Lachnospiraceae decreased significantly. The expression level of estradiol in the serum of infected Brandt's voles shows a slight decrease without statistical significance. However, the expression of equol is significantly higher in the infected group compared to the uninfected group, and the expression of enterolactone is significantly lower in the infected group than in the uninfected group.
Conclusions
This study demonstrates that infection with C. hepatica indirectly affect the abundance of gut microbiota in Brandt's voles, which are associated with reproductive hormones. This indirect effect on hormone expression can subsequently impact the reproductive function of the host. By investigating the changes in gut microbiota, this study sheds light on the mechanisms through which parasites regulate population fluctuations in Brandt's voles.
In Peroxide We Trust: A Cost-Effective Approach to Soil Microplastic Extraction
Authors: Susarla Bharath Ram 
Published: September 2023

Abstract
Soil is and always has been a defining aspect of human society and a key provider of insight into the nutrition and health of Homo sapiens. Soil Fertility is the ability of soil to facilitate plant growth by providing favorable physical, chemical, and biological nutrients & minerals (CHNOPS). Microplastics are toxic materials, less than or equal to 5 mm in length, which invade the world’s soils through urban sewage, amalgamating themselves with the SOM, thus threatening all biodiversity on Earth. Soil Sample Coordinates within 4-inch precision: 34°04'36.4"N 84°18'01.9"W. The Hydrogen Peroxide experimental group had a mean pH value of 6.09 for the entirety of the 40 days, which was significantly different than the pH of Birch seeds (6.44) and Control (6.51) groups. Future research can use NPK concentrations of a soil sample for testing soil fertility in addition to pH alone. Researchers in upcoming studies could also experimentally determine the efficiency of Hydrogen Peroxide as a density separation method for soil
microplastics at different experimental variables, such as soil type, microplastic type, and temperature ranges, which could yield completely different results.
Time-course change in the retinal artery angle after vitrectomy surgery in eyes with idiopathic epiretinal membrane
Authors: Nakamura Kentaro , Hirono Kazushi , Iwashita Yume , Nagura Koichi , Okawa Kazuyoshi , Inoue Tatsuya , Asaoka Ryo , Maruyama-Inoue Maiko , Yanagi Yasuo , Kadonosono Kazuaki 
Published: September 2023

Abstract

We investigated the relationship between time-course changes in the retinal artery angle and metamorphopsia in eyes with idiopathic epiretinal membrane (ERM). Over all, Thirty-seven patients who underwent vitrectomy surgery for ERM were enrolled. In addition to visual acuity (VA), the metamorphopsia score was measured for each eye using M-CHARTS. Moreover, pre- and postoperative retinal artery angle (YCA) was measured using ImageJ software. The difference between pre- and postoperative metamorphopsia score (Mdif), the difference between pre- and postoperative CRT (CRTdif) and the ratio of postoperative YCA to preoperative YCA (pYCA) were calculated and used for the statistical analysis. We investigated the relationship between Mdif and each of age, axial length (AL), pYCA, CRTdif and the follow-up duration. The association of pYCA with Mdif was also investigated in improved VA group (gained at least 0.2 logMAR) and unimproved VA group (gained less than 0.2 logMAR). The logMAR VA and metamorphopsia score significantly improved after vitrectomy surgery (both p < .001). The postoperative YCA was significantly larger than the preoperative YCA (p < 0.0001). Among age, AL, pYCA, CRTdif and the follow-up duration, pYCA and the follow-up duration were significantly associated with Mdif. Subgroup analysis indicated pYCA was significantly related to Mdif in unimproved VA group, but not in improved VA group. Monitoring the time-course change in the retinal artery angle might be useful for predicting the improvement in metamorphopsia after vitrectomy surgery in ERM eyes.
Unilateral retinal vein occlusion in a seven-year-old boy with a high level of lipoproteins (a)
Authors: Zhen Fang , Zhou Yongwei , Yuan Yueyue , Li Ting , Dong Shuqian 
Published: September 2023

Abstract
Purpose: To report a case of unilateral central retinal vein occlusion (CRVO) in a young patient with a high level of lipoprotein(a) (LP(a)).
Case presentation: A 7-year-old boy reported two days of vision loss in his left eye. The best-corrected visual acuity (BCVA) was 40 cm in front of his left eye. A complete fundus evaluation including fluorescein fundus angiography (FFA)showed CRVO in his left eye. Clinical laboratory tests showed a high level of Lp(a) in the patient, but his family had no known history of genetic and embolic disorders. Then, the patient’s left eye received anti-inflammatory andanti-infection treatments as well as an intravitreal dexamethasone (IVD) implant (Ozurdex®). The last follow-up examination showed that the BCVA of the left eye was improved to 0.4.
Conclusion: We describe a young patient diagnosed with CRVO with a high level of Lp(a). Young patients should be thoroughly evaluated to diagnose and initiate appropriate management at the earliest.
Lack of telomerase rescues cancer and shorter lifespan of zebrafish tp53 mutants
Authors: Naz Serifoglu , Ferreira Miguel Godinho 
Published: September 2023

Abstract
Telomerase activity is restricted in humans and telomere attrition occurs in several tissues accompanying natural aging. Critically short telomeres trigger DNA damage responses and activate p53 that result in apoptosis or replicative senescence. These processes reduce cell proliferation and disrupt tissue homeostasis, thus contributing to systemic aging. Zebrafish have restricted telomerase expression and telomeres shorten to critical length during their lifespan. Telomerase deficient zebrafish (tert-/-) is a premature model of aging, that anticipates both short telomeres and aging phenotypes. tert-/- zebrafish have impaired cell proliferation, accumulation of DNA damage markers and p53 response. These cellular defects lead to impaired tissue homeostasis, resulting in premature infertility, gastrointestinal atrophy, sarcopenia and kyphosis. These cellular defects, tissue impairments and degenerative phenotypes contribute to premature death of tert-/-zebrafish.
Mutation in tp53rescues accelerated aging of tert-/-zebrafish by enhancing proliferative capacity and restoring tissue homeostasis. However, the consequences of tp53 mutation at the organism level of tert-/-zebrafish were still undetermined. We show that tp53 mutation extends fertility, reduces aging phenotypes and prolongs life span. However, tp53 mutation does not rescue healthspan of tert-/- zebrafish, as it leads to increased inflammation and higher incidence of spontaneous tumors.
Measuring treatment burden in people with Type 2 Diabetes Mellitus (T2DM): A Mixed-methods Systematic Review
Authors: Lin Kai , YAO Mi , Ji Xinxin , LI Rouyan , ANDREW Lesley , OOSTHUIZEN Jacques , SIM Moira , CHEN Yongsong 
Published: September 2023

Abstract

Background: Workload related to Type 2 Diabetes Mellitus (T2DM) treatment imposes a substantial yet overlooked burden on patients, highlighting the need to identify optimal patient-reported outcome measures capable of capturing the unique treatment burdens faced by this population. The purpose of this systematic review was to identify the most robust approach for measuring treatment burden in people with Type 2 Diabetes Mellitus (T2DM) based on existing evidence.
Methods: The review included quantitative, mixed methods and qualitative studies measuring treatment burden in adults with T2DM and/or reporting patient treatment experiences. Articles from seven databases(Embase, PubMed, CINAHL, APA PsycInfo, CINAHL, CNKI, Wanfang and CBMWeb) were retrieved. Quality of included studies were assessed using the JBI Critical Appraisal Tool. The measurement properties of instrument were assessed using the COSMIN checklist. A mixed-methods design of systematic review was applied, synthesizing findings through a convergent segregated approach.
Results: 21,584 records were searched, and 26 articles were included for analysis, comprising 11 quantitative, 11 qualitative, and 4 mixed-methods studies. A thematic analysis of qualitative data engendered a conceptual framework that includes seven core measurements relevant to the treatment burden in T2DM. Themes less supported by current evidence were categorized as associated measurements. This conceptual framework directly guided the subsequent evaluation with COSMIN checklist. PETS, TBQ, and MTBQ achieved multiple positive ratings (between 6 and 8) on the COSMIN checklist, indicating strong Patient-Reported Outcome Measure (PROM) development process and ranking in the upper tertile among all evaluated instruments. PETS was identified as the top-performing instrument because it assessed most of the core measurements delineated in the conceptual framework and enabled separately calculated score for each component. Furthermore, the review found that the majority of existing research on the treatment burden of T2DM originates from developed countries, thereby potentially neglecting the variability present in developing or under-resourced settings.
Conclusions: This systematic review provides evidence for currently superior option of measuring treatment burden in people with T2DM. It also advocates for further research in under-resourced settings.
Protocal registration: A protocol was registered on the International Prospective Register of Systematic Reviews (CRD42022244190).