bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network evolution of regional brain volumes in young children reflects neurocognitive scores and mother’s education
Authors: Zhou Yidong , Müller Hans-Georg , Zhu Changbo , Chen Yaqing , Wang Jane-Ling , O’Muircheartaigh Jonathan , Bruchhage Muriel , Deoni Sean ,   RESONANCE Consortium, Braun Joseph , Bruchhage Muriel , Carnell Susan , Deoni Sean , D’Sa Viren , Huentelman Matthew , Klepac-Ceraj Vanja , LeBourgeois Monique , Müller Hans-Georg , O’Muircheartaigh Jonathan , Wang Jane-Ling 
Published: February 2023

AbstractThe maturation of regional brain volumes from birth to preadolescence is a critical developmental process that underlies emerging brain structural connectivity and function. Regulated by genes and environment, the coordinated growth of different brain regions plays an important role in cognitive development. Current knowledge about structural network evolution is limited, partly due to the sparse and irregular nature of most longitudinal neuroimaging data. In particular, it is unknown how factors such as mother’s education or sex of the child impact the structural network evolution. To address this issue, we propose a method to construct evolving structural networks and study how the evolving connections among brain regions as reflected at the network level are related to maternal education and biological sex of the child and also how they are associated with cognitive development. Our methodology is based on applying local Fréchet regression to longitudinal neuroimaging data acquired from the RESONANCE cohort, a cohort of healthy children (245 females and 309 males) ranging in age from 9 weeks to 10 years. Our findings reveal that sustained highly coordinated volume growth across brain regions is associated with lower maternal education and lower cognitive development. This suggests that higher neurocognitive performance levels in children are associated with increased variability of regional growth patterns as children age.
Itinerant-localized dichotomy in magnetic anisotropic properties of U-based ferromagnets
Authors: Shick Alexander B. , Halevy Itzhak , Tchaplianka Maxim , Legut Dominik 
Published: February 2023

AbstractThe electronic structure, spin and orbital magnetic moments, and the magnetic anisotropy energy in selected U-based compounds are investigated making use of the correlated band theory. First, we demonstrate that the LSDA+U approach with exact atomic limit implemented as a combination of the relativistic density functional theory with the Anderson impurity model provides a good quantitative description for UGa$${}_2$$

2

. Further, the method is applied to UFe$$_{12}$$

12

and UFe$${}_{10}$$

10

Si$${}_2$$

2

ferromagnets. The calculated positive uniaxial magnetic anisotropy together with negative enthalpy of formation for UFe$${}_{10}$$

10

Si$${}_2$$

2

make it as a candidate for the magnetically hard materials. Our studies suggest a viable route for further development of the rare-earth-lean permanent magnets by replacing a part of U atoms by some rare-earth like Sm in UFe$${}_{10}$$

10

Si$${}_2$$

2

.
Computational investigation of IP3 diffusion
Authors: Ornelas-Guevara Roberto , Gil Diana , Voorsluijs Valérie , Dupont Geneviève 
Published: February 2023

AbstractInositol 1,4,5-trisphosphate (IP3) plays a key role in calcium signaling. After stimulation, it diffuses from the plasma membrane where it is produced to the endoplasmic reticulum where its receptors are localized. Based on in vitro measurements, IP3 was long thought to be a global messenger characterized by a diffusion coefficient of ~ 280 μm2s−1. However, in vivo observations revealed that this value does not match with the timing of localized Ca2+ increases induced by the confined release of a non-metabolizable IP3 analog. A theoretical analysis of these data concluded that in intact cells diffusion of IP3 is strongly hindered, leading to a 30-fold reduction of the diffusion coefficient. Here, we performed a new computational analysis of the same observations using a stochastic model of Ca2+ puffs. Our simulations concluded that the value of the effective IP3 diffusion coefficient is close to 100 μm2s−1. Such moderate reduction with respect to in vitro estimations quantitatively agrees with a buffering effect by non-fully bound inactive IP3 receptors. The model also reveals that IP3 spreading is not much affected by the endoplasmic reticulum, which represents an obstacle to the free displacement of molecules, but can be significantly increased in cells displaying elongated, 1-dimensional like geometries.
Controllable Hartman effect by vortex beam in a one dimensional photonic crystal doped by graphene quantum dots
Authors: Kevin Saeideh , Sahrai Mostafa , Asadpour Seyyed Hossein 
Published: February 2023

AbstractThe Hartman effect is studied in a one dimensional photonic crystal doped with graphene quantum dots. It is shown that the Hartman effect can be switched from negative to positive by increasing the Rabi-frequency of the controlling field and also by manipulating the relative phase of the applied fields. The effect of the vortex beam on the Hartman effect is also presented. We show that the orbital angular momentum (OAM) and the azimuthal phase of the vortex beam do not affect the probe filed transmission while they change the Hartman effect from positive to negative.
Risk factors for stroke among anthropometric indices and lipid profiles in the Korean population: a large-scale cross-sectional study
Authors: Yim Mi Hong , Jeon Young Ju , Lee Bum Ju 
Published: February 2023

AbstractStroke is strongly associated with death and disability. However, the associations between stroke and lipid profiles such as total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), and red blood cells (RBCs) and anthropometric indices such as waist circumference and waist-to-height ratio (WHtR) remain unclear. The objective of this study was to investigate these relationships in a Korean population. This large-scale cross-sectional study included data from 38,190 subjects collected from 2010 to 2018 by the Korea National Health and Nutrition Examination Survey (KNHANES). Simple logistic regression models and multiple logistic regression models were used to evaluate the association of stroke with lipid profiles and anthropometric indices in the crude model, adjusted Model 1, and fully adjusted Model 2. In men, stroke was negatively associated with height, weight, and hematocrit level. Total cholesterol and triglycerides were strongly negatively associated with stroke in Model 2. Creatinine level and stroke were weakly associated. Additionally, height, weight, total cholesterol, triglycerides, and hematocrit and creatinine levels were associated with stroke both before and after adjustment. In women, in Model 2, stroke was positively associated with height, weight, and creatinine level. A strong negative association was found between total cholesterol and stroke. Stroke was negatively associated with hemoglobin level, hematocrit level, and RBCs. Additionally, total cholesterol, hemoglobin level, hematocrit level, creatinine level, and RBCs were associated with stroke both before and after adjustment. Weight and height were more closely associated with stroke than waist circumference and WHtR in Korean men. Our results suggested that the association of stroke with triglycerides, height, and weight differed according to sex and that HDL-C was not associated with stroke in people of either sex.
Optimizing the operation strategy of a combined cooling, heating and power system based on energy storage technology
Authors: Zhang Yu , Deng Yan , Zheng Zimin , Yao Yao , Liu Yicai 
Published: February 2023

AbstractEnergy storage technology is the key to achieving a carbon emission policy. The purpose of the paper is to improve the overall performance of the combined cooling, heating and power-ground source heat pump (CCHP-GSHP) system by the battery. A new operation strategy (the two-point operation) is proposed by controlling the power generation unit work. The power generation unit has two operation modes of non-operation and rated efficiency operation by the storage electricity battery. The new operation strategy is compared with the traditional CCHP-GSHP that without a battery. The optimization goals include the primary energy saving ratio, the reduction ratio of carbon dioxide emissions, and the annual total cost saving ratio. The independent GSHP system is used as a reference system. Multipopulation genetic algorithms are selected to achieve the problem of optimization. A hotel building is selected for a case study. The optimal configuration of the coupling system is computed following the electric load strategy. Finally, the results show that the CCHP-GSHP system has a better performance under the new operation strategy compared with the traditional CCHP-GSHP (the primary energy saving ratio increases by 5.5%; the annual carbon dioxide emission reduction ratio increases by 1%; the annual total cost reduction ratio increases by 5.1%). This paper provides reference and suggestions for the integration and operation strategy of CCHP-GSHP in the future.
Isovists compactness and stairs as predictors of evacuation route choice
Authors: Snopková Dajana , De Cock Laure , Juřík Vojtěch , Kvarda Ondřej , Tancoš Martin , Herman Lukáš , Kubíček Petr 
Published: February 2023

AbstractThe building design is a crucial factor that can be actively adjusted and optimized to prevent human and property threats in emergency scenarios. Previous research suggests that specific building layouts may significantly influence human behaviour during evacuation. However, detailed empirical data about human behaviour in various types of buildings with different layouts are still missing and only marginal recommendations from this field are reflected in actual construction practice. In this study, desktop VR technologies were employed to study human decision-making in problematic T-intersections in the context of an emergency evacuation. More specifically, we studied fundamental attributes of buildings such as the width and length of the corridors and the presence of stairs to explore how they influence the choice of the evacuation route. The space-syntax isovist method was used to describe spatial parameters of corridors, which makes the results applicable to all buildings. Behavioural data from 208 respondents were analysed using multilevel regression models. Our results support previous claims concerning the importance of specific spatial layouts of evacuation corridors because respondents systematically chose wider and shorter corridors with visible staircases as the preferred evacuation route. The present findings further promote the ongoing discussion on the design of marked evacuation routes and building design that takes human factors into consideration.
Analysis of gaze patterns during facade inspection to understand inspector sense-making processes
Authors: Saleem Muhammad Rakeh , Mayne Robert , Napolitano Rebecca 
Published: February 2023

AbstractThis work seeks to capture how an expert interacts with a structure during a facade inspection so that more detailed and situationally-aware inspections can be done with autonomous robots in the future. Eye tracking maps where an inspector is looking during a structural inspection, and it recognizes implicit human attention. Experiments were performed on a facade during a damage assessment to analyze key, visually-based features that are important for understanding human-infrastructure interaction during the process. For data collection and analysis, experiments were conducted to assess an inspector’s behavioral changes while assessing a real structure. These eye tracking features provided the basis for the inspector’s intent prediction and were used to understand how humans interact with the structure during the inspection processes. This method will facilitate information-sharing and decision-making during the inspection processes for collaborative human-robot teams; thus, it will enable unmanned aerial vehicle (UAV) for future building inspection through artificial intelligence support.
A tool to enhance antimicrobial stewardship using similarity networks to identify antimicrobial resistance patterns across farms
Authors: Aguilar-Vega Cecilia , Scoglio Caterina , Clavijo María J. , Robbins Rebecca , Karriker Locke , Liu Xin , Martínez-López Beatriz 
Published: February 2023

AbstractAntimicrobial resistance (AMR) is one of the major challenges of the century and should be addressed with a One Health approach. This study aimed to develop a tool that can provide a better understanding of AMR patterns and improve management practices in swine production systems to reduce its spread between farms. We generated similarity networks based on the phenotypic AMR pattern for each farm with information on important bacterial pathogens for swine farming based on the Euclidean distance. We included seven pathogens: Actinobacillus suis, Bordetella bronchiseptica, Escherichia coli, Glaesserella parasuis, Pasteurella multocida, Salmonella spp., and Streptococcus suis; and up to seventeen antibiotics from ten classes. A threshold criterion was developed to reduce the density of the networks and generate communities based on their AMR profiles. A total of 479 farms were included in the study although not all bacteria information was available on each farm. We observed significant differences in the morphology, number of nodes and characteristics of pathogen networks, as well as in the number of communities and susceptibility profiles of the pathogens to different antimicrobial drugs. The methodology presented here could be a useful tool to improve health management, biosecurity measures and prioritize interventions to reduce AMR spread in swine farming.
Presaccadic attention sharpens visual acuity
Authors: Kwak Yuna , Hanning Nina M. , Carrasco Marisa 
Published: February 2023

AbstractVisual perception is limited by spatial resolution, the ability to discriminate fine details. Spatial resolution not only declines with eccentricity but also differs for polar angle locations around the visual field, also known as ‘performance fields'. To compensate for poor peripheral resolution, we make rapid eye movements—saccades—to bring peripheral objects into high-acuity foveal vision. Already before saccade onset, visual attention shifts to the saccade target location and prioritizes visual processing. Thispresaccadic shift of attentionimproves performance in many visual tasks, but whether it changes resolution is unknown. Here, we investigated whether presaccadic attention sharpens peripheral spatial resolution; and if so, whether such effect interacts with performance fields asymmetries. We measured acuity thresholds in an orientation discrimination task during fixation and saccade preparation around the visual field. The results revealed that presaccadic attention sharpens acuity, which can facilitate a smooth transition from peripheral to foveal representation. This acuity enhancement is similar across the four cardinal locations; thus, the typically robust effect of presaccadic attention does not change polar angle differences in resolution.
Diversification of the shell shape and size in Baikal Candonidae ostracods inferred from molecular phylogeny
Authors: Karanovic Ivana , Pham Huyen T. M. , Sitnikova Tatiana 
Published: February 2023

AbstractOstracod shells are used extensively in paleontology, but we know little about their evolution, especially in ancient lakes. Lake Baikal (LB) is the world’s most important stronghold of Candonidae diversity. These crustaceans radiated here rapidly (12–5 Ma) and with an unprecedented morphological diversity. We reconstruct their molecular phylogeny with 46 species and two markers (18S and 16S rRNA), and use it to estimate the evolution of the shell shape and size with landmark-based geometric morphometrics (LBGM). High posterior probabilities support four major clades, which differ in node depth and morphospace clustering. After removing a significant allometry, the first three principal components (PCs) describe about 88% of total variability, suggesting a strong integration. Reconstructed ancestral shapes are similar for all four clades, indicating that diversification happened after colonization. Major evolutionary changes occurred from trapezoidal to elongated shapes. Sister species are separated in morphospace, by centroid size, or both, as well as by vertical and horizontal distributions in LB. Ostracod shell is a strongly integrated structure that exhibits high evolvability, with some extreme shapes, although mostly along the first PC. This is the first study that combines molecular phylogeny and LBGM for ostracods and for any LB group.
Molecular mechanism of valine and its metabolite in improving triglyceride synthesis of porcine intestinal epithelial cells
Authors: Xu Mengmeng , Che Long , Niu Lizhu , Wang Liuzhen , Li Mengyun , Jiang Dongfeng , Deng Hongyu , Chen Wen , Jiang Zongyong 
Published: February 2023

AbstractAn insufficient energy supply to intestinal epithelial cells decreases production performance in weaned piglets. Triglycerides are the main energy source for intestinal epithelial cells in piglets. The present study aimed to investigate the effects and mechanisms of valine supplementation on triglyceride synthesis in porcine intestinal epithelial (IPEC-J2) cells. Valine supplementation in the medium significantly increased the content of triglycerides, fat droplets, and long-chain fatty acids (C17:0, C18:0, C20:0, C18:1, C20:1, and C22:1) (P < 0.05). Valine metabolite (3-hydroxyisobutyrate [3-HIB]) concentration increased significantly in the valine-supplemented group (P < 0.05). Silencing of the 3-HIB synthase enzyme 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) in IPEC-J2 cells significantly reduced the triglyceride concentration and lipid droplet synthesis. Further studies found that 3-HIB supplementation in the medium significantly increased the concentration of triglycerides, lipid droplets, and unsaturated fatty acids (C16:1, C18:1, C18:2, C18:3, C20:3, C20:4, and C20:5) (P < 0.05) by upregulating the expression of proteins involved in fatty acid transport (CD36) and fatty acid binding protein 3 (FABP3) or triglyceride synthesis (DGAT1) (P < 0.05), indicating that 3-HIB mediates valine-enhanced triglyceride synthesis in IPEC-J2 cells. In conclusion, our results demonstrated that valine enhanced triglyceride synthesis in IPEC-J2 cells via increasing the 3-HIB concentration, which may promote fatty acid transport via upregulation of proteins related to fatty acid transporter. These findings provide new insights into the mechanisms through which valine participates in lipid metabolism.
Insecticidal activity of essential oils from American native plants against Aedes aegypti (Diptera: Culicidae): an introduction to their possible mechanism of action
Authors: Duque Jonny E. , Urbina Diana L. , Vesga Luis C. , Ortiz-Rodríguez Luis A. , Vanegas Thomas S. , Stashenko Elena E. , Mendez-Sanchez Stelia C. 
Published: February 2023

AbstractSearching for new bioactive molecules to design insecticides is a complex process since pesticides should be highly selective, active against the vector, and bio-safe for humans. Aiming to find natural compounds for mosquito control, we evaluated the insecticidal activity of essential oils (EOs) from 20 American native plants againstAedes aegyptilarvae using bioassay, biochemical, and in silico analyses. The highest larvicide activity was exhibited by EOs fromSteiractinia aspera(LC50 = 42.4 µg/mL),Turnera diffusa(LC50 = 70.9 µg/mL),Piper aduncum(LC50 = 55.8 µg/mL),Lippia origanoides(chemotype thymol/carvacrol) (LC50 = 61.9 µg/mL),L. origanoides(chemotype carvacrol/thymol) (LC50 = 59.8 µg/mL),Hyptis dilatata(LC50 = 61.1 µg/mL),Elaphandra quinquenervis(LC50 = 61.1 µg/mL), andCalycolpus moritzianus(LC50 = 73.29 µg/mL) after 24 h. This biological activity may be related to the disruption of the electron transport chain through the mitochondrial protein complexes. We hypothesized that the observed EOs' effect is due to their major components, where computational approaches such as homology modeling and molecular docking may suggest the possible binding pose of secondary metabolites that inhibit the mitochondrial enzymes and acetylcholinesterase activity (AChE). Our results provided insights into the possible mechanism of action of EOs and their major compounds for new insecticide designs targeting the mitochondria and AChE activity inA. aegyptifor effective and safe insecticide.
Long-term health-related quality of life after trauma with and without traumatic brain injury: a prospective cohort study
Authors: Kiwanuka Olivia , Lassarén Philipp , Thelin Eric P. , Hånell Anders , Sandblom Gabriel , Fagerdahl Ami , Boström Lennart 
Published: February 2023

AbstractTo purpose was to assess and compare the health-related quality of life (HRQoL) and risk of depression two years after trauma, between patients with and without traumatic brain injury (TBI) in a mixed Swedish trauma cohort. In this prospective cohort study, TBI and non-TBI trauma patients included in the Swedish Trauma registry 2019 at a level II trauma center in Stockholm, Sweden, were contacted two years after admission. HRQoL was assessed with RAND-36 and EQ-5D-3L, and depression with Montgomery Åsberg depression Rating Scale self-report (MADRS-S). Abbreviated Injury Score (AIS) head was used to grade TBI severity, and American Society of Anesthesiologists (ASA) score was used to assess comorbidities. Data were compared using Chi-squared test, Mann Whitney U test and ordered logistic regression, and Bonferroni correction was applied. A total of 170 of 737 eligible patients were included. TBI was associated with higher scores in 5/8 domains of RAND-36 and 3/5 domains of EQ-5D (p < 0.05). No significant difference in MADRS-S. An AIS (head) of three or higher was associated with lower scores in five domains of RAND-36 and two domains of EQ-5D but not for MADRS-S. An ASA-score of three was associated with lower scores in all domains of both RAND-36 (p < 0.05, except mental health) and EQ-5D (p < 0.001, except anxiety/depression), but not for MADRS-S. In conclusion, patients without TBI reported a lower HRQoL than TBI patients two years after trauma. TBI severity assessed according to AIS (head) was associated with HRQoL, and ASA-score was found to be a predictor of HRQoL, emphasizing the importance of considering pre-injury health status when assessing outcomes in TBI patients.