bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Self‐Enhancing Nanoreactor Reinforces Radioimmunotherapy by Reprogramming Nutrients and Redox Metabolisms
Authors: Hou Mengfei , Su Haiyang , Wu Qinghe , Sun Wenshe , Zhang Pengli , Jiang Yifei , Qian Kun , Zhang Chunfu 
Published: January 2023

AbstractAltered metabolism of cancer cells reshapes the unique tumor microenvironment (TME) with glucose addiction and high antioxidant levels, resulting in a strong alliance to promote tumor progression and treatment failure. Herein, a Pd/Pt/Au tri‐metallic mesoporous nanoparticle coated with pH‐responsive tannic acid‐iron ion (FeIIITA) network (PdPtAu@TF) is fabricated, aiming at reinforcing radioimmunotherapy by reprogramming nutrients and redox metabolisms. PdPtAu@TF has a fine hierarchical structure and demonstrates high glucose oxidase, peroxidase‐, catalase‐ and glutathione peroxidase‐mimic activities, acting as a self‐enhancing nanoreactor to consume endogenous glucose and break redox homeostasis in the harsh TME. As a result, cancer cells accelerate the uptake of lipids, especially polyunsaturated fatty acids when glucose is deficient, and then fall into lipid peroxidation‐induced ferroptosis trap to sensitize radiotherapy (RT), inhibiting tumor progression. More significantly, combined treatment with PdPtAu@TF can promote the polarization of pro‐inflammatory M1‐type macrophages as well as inhibit the proliferation of cancer‐associated fibroblasts to overcome RT‐induced immunosuppression and eliminate excessive tissue fibrosis, thereby eliciting antitumor immunity and suppressing tumor metastasis. Consequently, this study describes a promising strategy to enhance the efficacy of radioimmunotherapy by reprogramming tumor nutrients and redox metabolisms, which has great potential to benefit cancer treatments.
Encapsulating and Operating a Stable Li3ErBr6‐Based Solid Li–SeS2 Battery at Room Temperature
Authors: Shi Xiaomeng , Zeng Zhichao , Zhang Hongtu , Huang Yunhui , Yan Chun‐Hua , Du Yaping 
Published: January 2023

AbstractRare earth‐based halide solid electrolytes (RE‐HSEs) are noted due to their comprehensive properties of good ionic conductivity, electrochemical window, and deformability. However, the types and applications of RE‐HSEs need to be further expanded. Here, a highly purified RE‐HSE Li3ErBr6 (LErB) is synthesized successfully by a vacuum evaporation method. The prepared LErB possesses a high ionic conductivity of 1.0 mS cm−1 with an electrochemical window of 1.5–3.4 V. The LErB is applied in a solid Li–SeS2 battery, which can realize stable cycling performance for 300 cycles and good rate performance at room temperature. Moreover, to evaluate the practicability of the LErB‐based Li–SeS2 battery, a pouch‐type cell is assembled, which can light a diode array even after bending and cutting. These results demonstrate that LErB‐based solid Li–SeS2 cells possess advantages in battery packaging and operation, which can improve the practicability of all‐solid‐state lithium batteries.
Histone Deacetylase‐Triggered Self‐Immolative Peptide‐Cytotoxins for Cancer‐Selective Drug Delivery
Authors: Bai Haoyu , Wang Huifang , Zhou Zhuha , Piao Ying , Liu Xiangrui , Tang Jianbin , Shen Xian , Shen Youqing , Zhou Zhuxian 
Published: January 2023

AbstractPrecise delivery and release of therapeutics in the subcellular targets are critical for tumor‐selective chemotherapy. Self‐immolative structures are sophisticatedly designed to achieve stimuli‐responsive drug delivery. Herein, the facile fabrication of self‐immolative peptide‐camptothecin (CPT) nanoassemblies is reported for cancer‐selective drug delivery by utilizing the dual‐mode peptide targeting design and amine‐catalyzed intramolecular hydrolysis. The dual‐mode peptide targeting design is realized by co‐assembly of tumor targeting and nuclei‐localizing peptide‐CPT prodrugs, rendering the nanoassemblies with efficient cancer cell‐selective capability. When the nanoassemblies enter cancer cell, the overexpressed endonuclear histone deacetylases (HDACs) cleave the acetyl group to generate primary amines, triggers amine‐catalyzed intramolecular hydrolysis, and fast‐release drug in the cell nuclei. The peptide‐CPT prodrugs release up to 68% CPT in 1 h in the presence of HDACs, while no detectable CPT release is observed in the absence of HDACs at the same time. The peptide‐CPT prodrugs selectively kill cancer cells with high HDACs levels. The dual targeting peptide‐CPT nanoassemblies exhibit extended blood circulation, excellent tumor accumulation, and potent antitumor activity by inhibiting tumor progression and metastasis in mice bearing 4T1 aggressive breast tumors. Overall, the HDAC‐triggered self‐immolative strategy is promising for developing cancer‐selective drug delivery systems.
A Biomimetic Lubricating Nanosystem with Responsive Drug Release for Osteoarthritis Synergistic Therapy
Authors: Li Cheng , Gong Peiwei , Chao Mianran , Li Juan , Yang Liyan , Huang Yan , Wang Dandan , Liu Jianxi , Liu Zhe 
Published: January 2023

AbstractOsteoarthritis (OA) is associated with lubrication failure of articular cartilage and severe inflammatory response of joint capsule. Synergistic therapy combining joint lubrication and anti‐inflammation emerges as a novel treatment of OA. In this study, bioinspired by ultralow friction of natural articular synovial fluid and mussel adhesion chemistry, a biomimetic nanosystem with dual functions of enhanced lubrication and stimuli‐responsive drug release is developed. A dopamine mediated strategy realizes one step biomimetic grafting of hyaluronic acid (HA) on fluorinated graphene. The polymer modified sheets exhibit highly efficient near‐infrared absorption, and show steady lubrication with a long time under various working conditions, in which the coefficient of friction is reduced by 75% compared to H2O. Diclofenac sodium (DS) with a high loading capacity of 29.2% is controllably loaded, and responsive and sustained drug release is adjusted by near‐infrared light. Cell experiments reveal that the lubricating nanosystem is taken up by endocytosis, and anti‐inflammation results confirm that the nanosystem inhibits osteoarthritis deterioration by upregulating cartilage anabolic gene and downregulating catabolic proteases and pain‐related gene. This work proposes a promising biomimetic approach to integrate polymer modified fluorinated graphene as a dual‐functional nanosystem for effective synergistic therapy of OA.
Strong Interlayer Coupling in Twisted Transition Metal Dichalcogenide Moiré Superlattices
Authors: Zheng Haihong , Guo Hongli , Chen Shula , Wu Biao , Li Shaofei , He Jun , Liu Zongwen , Lu Gang , Duan Xidong , Pan Anlian , Liu Yanping 
Published: January 2023

AbstractMoiré superlattices in twisted van der Waals materials offer a powerful platform for exploring light–matter interactions. The periodic moiré potentials in moiré superlattices can induce strongly correlated quantum phenomena that depend on the moiré potential associated with interlayer coupling at the interface. However, moiré superlattices are primarily prepared by mechanical exfoliation and manual stacking, where the transfer methods easily cause interfacial contamination, and the preparation of high‐quality bilayer 2D materials with small twist angles by growth methods remains a significant challenge. In this work, WSe2/WSe2 homobilayers with different twist angles by chemical vapor deposition (CVD), using a heteroatom‐assisted growth technique, are synthesized. Using low‐frequency Raman scattering, the uniformity of the moiré superlattices is mapped to demonstrate the strong interfacial coupling of the CVD‐fabricated twist‐angle homobilayers. The moiré potential depths of the CVD‐grown and artificially stacked homostructures with twist angles of 1.5° are 115 and 45 meV (an increase of 155%), indicating that the depth of moiré potential can be modulated by the interfacial coupling. These results open a new avenue to study the modulation of moiré potential by strong interlayer coupling and provide a foundation for the development of twistronics.
Instantaneous Formation of Silk Protein Aerosols and Fibers with a Portable Spray Device under Ambient Conditions
Authors: Choi Jaewon , Sahoo Jugal Kishore , Hasturk Onur , Falcucci Thomas , Yao Ya , Kaplan David L. 
Published: January 2023

AbstractA variety of artificial silk spinning approaches are attempted to mimic the natural spinning process found in silkworms and spiders, yet instantaneous silk fiber formation with hierarchical structure under physiological and ambient conditions without post‐treatment procedures remains unaddressed. Here, this work reports a new strategy to fabricate silk protein‐based aerosols and silk fibers instantaneously in situ using a spray device, avoiding complicated and costly advanced manufacturing techniques. The key to success is the instantaneous conformational transition of silk fibroin from random coil to β‐sheet right before spraying by mixing silk and polyethylene glycol (PEG) solutions in the spray device, allowing aerosols and silk fibers to be sprayed, with further control achieved via the molecular weight of silk. The spinning process of the spray device is based on the use of green solvents, that is, all steps of instant conformational transition of silk fibroin are carried out in aqueous conditions or with buffers at ambient conditions, in combination with shear and elongational flow caused by the hydraulic pressure generated in the spray container. The system supports a portable and user‐friendly system that could be used for drug delivery carriers, wound coating materials, and rapid silk fiber conformal coatings on surfaces.
Flexible Plasmonic Optical Tactile Sensor for Health Monitoring and Artificial Haptic Perception
Authors: Guo Jingjing , Shang Ce , Gao Shuo , Zhang Yongbiao , Fu Bo , Xu Lijun 
Published: January 2023

AbstractTactile sensors capable of quantifying mechanical stimuli through physical contact play a pivotal role in healthcare, prosthetics, and humanoid robotics. To enable conformal contact with objects of different surface morphologies, tactile sensors with high mechanical flexibility are extensively explored. Despite recent advances, most of the currently available flexible tactile sensors are based on electrical properties of functional materials, which often suffer from intrinsic limitations such as hysteresis, parasitic effects and electromagnetic interference. Herein, a flexible optical tactile sensor is presented by harnessing the unique optical properties of a soft and plasmonic optical fiber, made from composites of gold nanoparticles and elastomers. The tactile sensor is constructed by assembling the nanocomposite fiber in a sandwich structure, where sensitive and instantaneous sensing of contact force with high precision, low hysteresis, and tunable sensitivity is achieved by transducing mechanical stimuli into interpretable light signals. As demonstrations of its potential, the tactile sensor is utilized for real‐time monitoring of blood pressure, respiration, as well as providing tactile mapping of diverse hand motions. To further verify the feasibility of mimicking tactile perception of human skin, the proposed sensors integrated onto a robotic hand are demonstrated to perceive hardness, roughness, and shape of objects.
Ultra‐Stretchable, Adhesive, and Anti‐Swelling Ionogel Based on Fluorine‐Rich Ionic Liquid for Underwater Reliable Sensor
Authors: Zhao Ye , Gan Dingli , Wang Leichen , Wang Siying , Wang Wenjun , Wang Qian , Shao Jinjun , Dong Xiaochen 
Published: January 2023

AbstractCreating flexible materials that can work underwater has the potential to broaden applications to aquatic and marine environments. Hydrogels have long been thought to be excellent ionic conductors for wearable electronics, because of their high stretchability, transparency, and excellent ionic conductivity. However, due to the huge differences between the underwater and air environments, the previously reported soft materials can rarely satisfy the critical needs of adhesive, underwater stability, and steady conductivity. Herein, an ionogel is proposed with abundant physical and chemical cross‐linked, involving ion‐dipole, electrostatic, and hydrogen bonding interactions, to achieve excellent mechanical strength, resilience, and underwater stability. The ionogel with long‐lasting underwater adherence and durability is further assembled into a high sensitivity, fast response, and excellent durability underwater wearable sensor. The ionogel sensor demonstrated high precision in various human motion detection and Morse code is used to transmit information both in the air and underwater. In addition, the tough underwater adhesion and the distinct discrepancy in electrical properties in different concentration solutions enable the ionogel sensor to adhere to the surface of marine animals and monitor the water quality in their habitats. It is identified that the designed ionogel possesses great promise in wearable devices and soft ionotronics.
High Precision Dynamic Manipulations of Large‐Volume‐Range Water‐Based Droplets by a Soft Gripper with Robust Water‐Repellent Superhydrophobic Surface
Authors: Wang Haipeng , Zhang Qingyi , Li Xinxin , Yan Peng , Guan Yingchun 
Published: January 2023

AbstractDroplet manipulation has emerged as a key enabling technology in various scientific and engineering fields with great potentials in advanced applications such as bioanalysis and reagent microreactors. The current strategies generally involve external stimuli or chemical/structural surface gradients to provide the driving force for in plane droplet manipulations, which suffer from low efficiency, poor controllability, and small volume ranges (generally Vmax/Vmin < 10) due to their inherent limitations. Herein, a dynamic gripping based droplet manipulation method is proposed by employing a flexible gripper with a notch covered by superhydrophobic silicon rubber membrane (SRM) between the gripper fingers to dynamically pick up, constrain and release droplets, capable of consecutively manipulating large‐volume‐range (Vmax/Vmin >130) droplets with minimal liquid loss. The robust Cassie‐to‐Wenzel transition (CWT) resistance and mechanical stability of the produced superhydrophobic surface well support the dynamic operations of various droplets, where the superhydrophobic surface presents great water‐repellent performance during stretching and impinging experiments as well as remains superhydrophobicity even after mechanical abrasion against 600 grit SiC sandpaper for 15 m at an applied pressure of 3.2 kPa. Lossless manipulations of 3–180 µL droplets have been experimentally validated, where an application of the proposed method in droplet‐based microreactors for chemical analysis and bioassay is demonstrated.
Chemical Optimization Strategy of Rapid Additive Manufacturing via Up‐Conversion Assisted Photopolymerization Based Direct Ink Writing
Authors: Zhu Junzhe , Guo Zhenpeng , Zhou Yufan , Zou Xiucheng , Zhu Ye , Liu Yu , Liu Ren 
Published: January 2023

AbstractLight‐driven 3D printing can empower the liberty of creation and concretize the original creation in versatile conditions with plenty of choices in resolution or properties. However, photopolymerization‐based 3D printing inks are facing a trade‐off between requiring processing rate and satisfying performance, and a chemical optimization strategy is proposed to achieve the ink demands of rapid direct ink writing utilizing up‐conversion assisted photopolymerization. Since acylphosphonate can generate two reactive radicals and tertiary amine can reinitiate polymerization in oxygen inhibition, the yielded active species in limited irradiation of 3D printing are maximized to accelerate the polymerization by theoretically and experimentally interpreting the roles of up‐conversion particle, photoinitiators, and co‐initiator played in printing. High print speed in depositing and in situ curing (3.56 × 104 mm3 h−1) are realized, and the manufacturing time is shortened by multi‐resolution printing which is impressive compared to current 3D printing methods. The strategy is simultaneously compatible with rigid and elastomeric materials, and will surely contribute to other light‐driven 3D printing technologies for extensive applications.
Local Structure and Self‐Defect Evolution under Nonstoichiometric Effect Unlock Zero‐Thermal‐Quenching
Authors: Ma Xilin , Wang Yuhua 
Published: January 2023

AbstractObtaining phosphors with higher quenching temperatures is a key scientific problem in developing high‐quality full‐spectrum white lighting devices. Herein, a near ultraviolet (NUV) activated orange‐yellow‐emitting single‐phase Li2Sr1‐ΔSiO4:Eu2+ phosphor is synthesized based on a nonstoichiometric ratio (Δ), and the relationship between local structure and photoluminescence (PL) is studied by electron spin resonance spectrum (ESR), Raman spectrum and density functional theory (DFT) calculations. Under the nonstoichiometric ratio effect, the local structure maintains stability by varying bond lengths, interatomic bond properties, and symmetry of coordination polyhedrons, which in turn modulates the crystal field and the PL spectra. Moreover, the optimum sample (Δ = 0.1%) specifically remains at 102%, 110%, and 114% of PL intensities at 150, 200, and 225 °C, respectively, compared with the initial at 25 °C, and the zero‐thermal‐quenching is mainly compensated by certain wide‐distributed self‐defect levels (300–550 K). Finally, a white light emitting diode with high luminous efficiency (89.61 lm W−1), low corresponding color temperature (5352 K), and good color rendering index (Ra = 95.8) is successfully fabricated. The strategy of designing self‐defect by nonstoichiometric synthesis provides a new insight for developing novel thermal‐quenching resistant phosphors and applying potential.
Recent Progress of Paclitaxel Delivery Systems: Covalent and Noncovalent Approaches
Authors: Wang Jiaoyang , Li Xueqiao , Wu Wenna , Xu Xin‐Ming , Xu Hui , Zhang Tao 
Published: January 2023

AbstractPaclitaxel (PTX) is a broad‐spectrum alkaloid anticancer drug with high therapeutic efficacy. However, PTX has a very low water solubility and its metabolism demonstrates nonlinear pharmacokinetic characteristics, resulting in systemic adverse reactions in clinical applications. Many endeavors are devoted to develop new PTX preparations in response to these obstacles, and some are used in clinical phase of cancer treatment. In particular, highly specific medical intervention at nanoscale is an emerging research field focusing on nanoapproaches to solve clinical problems. In a perspective of nanomedicine, the recent covalent and noncovalent approaches toward PTX formulation on various substrates, as well as their advantages and disadvantages during preclinical researches and clinical applications are herein summarized. It is anticipated that nanotechnology‐based drug delivery systems can further enhance therapeutic efficiencies of PTX, by reducing systemic side effects and alleviating severely negative effects on patients.
Organic Photothermal Cocrystals: Rational Design, Controlled Synthesis, and Advanced Application
Authors: Chen Ye‐Tao , Zhuo Ming‐Peng , Wen Xinyi , Chen Wenbin , Zhang Ke‐Qin , Li Ming‐De 
Published: January 2023

AbstractOrganic photothermal cocrystals, integrating the advantages of intrinsic organic cocrystals and the fascinating photothermal conversion ability, hold attracted considerable interest in both basic science and practical applications, involving photoacoustic imaging, seawater desalination, and photothermal therapy, and so on. However, these organic photothermal cocrystals currently suffer individual cases discovered step by step, as well as the deep and systemic investigation in the corresponding photothermal conversion mechanisms is rarely carried out, suggesting a huge challenge for their further developments. Therefore, it is urgently necessary to investigate and explore the rational design and synthesis of high‐performance organic photothermal cocrystals for future applications. This review first and systematically summarizes the organic photothermal cocrystal in terms of molecular classification, the photothermal conversion mechanism, and their corresponding applications. The timely interpretation of the cocrystal photothermal effect will provide broad prospects for the purposeful fabrication of excellent organic photothermal cocrystals toward great efficiency, low cost, and multifunctionality.
Culinary cultural immersion: A qualitative analysis of resident knowledge, attitudes, and behavioral changes following a brief Somali cultural immersion experience
Authors: Paetow Glenn , Scott Nate , Panning Ali , Hopkins Jared , Aden Muhiyadin , Hart Danielle 
Published: January 2023

AbstractBackgroundTeaching cultural humility is required by the Accreditation Council for Graduate Medical Education and can improve patient satisfaction and health care outcomes. Because one‐third of the 150,000 Somali immigrants and refugees in the United States live in Minnesota, we aimed to determine whether a brief cultural immersion experience, where small groups of residents share a meal with Somali interpreters at a Somali restaurant, would affect resident knowledge, attitudes, and behaviors when caring for Somali patients in a Minnesota emergency department.MethodsFrom October 2017 to September 2018, emergency medicine residents were invited to dinners held outside of regular clinical/academic hours. Dinners took place at a Somali restaurant and were facilitated by a Somali interpreter and a faculty physician. While they were designed as learner‐driven sessions, facilitators were encouraged to discuss specific themes. In addition to an evaluation survey, participants underwent semistructured interviews after the experiences, and a qualitative analysis of derived themes is reported.ResultsSix dinners were hosted for a total of 20 residents, with 17 (85%) completing the evaluation survey and interview. Residents strongly agreed that this experience was worth their time and would recommend the program. Residents reported an increase in their knowledge of Somali culture, health care paradigms, and diet. Behavioral changes were described, including how residents greet patients, tailor clinical visits to patient expectations, and use interpreters as cultural brokers. Attitudinal changes were reported to a lesser degree but included an increased acceptance of cultural differences and an increased sense of connectedness to this population. Finally, residents reported that the benefits of this program were due to the authenticity of the experience, the informal small‐group setting, and their sense of being in the minority during the dinners.ConclusionsA brief immersion experience at a Somali restaurant was sufficient to result in increased knowledge, attitudinal, and behavioral changes when caring for Somali patients.