bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior
Authors: Costello Hannah M , Crislip G Ryan , Cheng Kit-Yan , Lynch I Jeanette , Juffre Alexandria , Bratanatawira Phillip , Mckee Annalisse , Thelwell Ryanne S , Mendez Victor M , Wingo Charles S , Douma Lauren G , Gumz Michelle L 
Published: January 2023

Abstract
Brain and muscle ARNT-like 1 (BMAL1) is a core circadian clock protein and transcription factor that regulates many physiological functions, including blood pressure (BP). Male global Bmal1 knockout (KO) mice exhibit ∼10 mmHg reduction in BP, as well as a blunting of BP rhythm. The mechanisms of how BMAL1 regulates BP remains unclear. The adrenal gland synthesizes hormones, including glucocorticoids and mineralocorticoids, that influence BP rhythm. To determine the role of adrenal BMAL1 on BP regulation, adrenal-specific Bmal1 (ASCre/+::Bmal1) KO mice were generated using aldosterone synthase Cre recombinase to KO Bmal1 in the adrenal gland zona glomerulosa. We confirmed the localization and efficacy of the KO of BMAL1 to the zona glomerulosa. Male ASCre/+::Bmal1 KO mice displayed a shortened BP and activity period/circadian cycle (typically 24 h) by ∼1 h and delayed peak of BP and activity by ∼2 and 3 h, respectively, compared with littermate Cre- control mice. This difference was only evident when KO mice were in metabolic cages, which acted as a stressor, as serum corticosterone was increased in metabolic cages compared with home cages. ASCre/+::Bmal1 KO mice also displayed altered diurnal variation in serum corticosterone. Furthermore, these mice have altered eating behaviors where they have a blunted night/day ratio of food intake, but no change in overall food consumed compared with controls. Overall, these data suggest that adrenal BMAL1 has a role in the regulation of BP rhythm and eating behaviors.
Automatic Split-Generation for the Fukaya Category
Authors: Perutz Timothy , Sheridan Nick 
Published: January 2023

Abstract
We prove a structural result in mirror symmetry for projective Calabi–Yau (CY) manifolds. Let $X$ be a connected symplectic CY manifold, whose Fukaya category $\mathcal {F}(X)$ is defined over some suitable Novikov field ${\mathbb {K}}$; its mirror is assumed to be some smooth projective ${\mathbb {K}}$-variety $Y$ that is “maximally degenerating”. Suppose that some split-generating subcategory of (a $\textsf {dg}$ enhancement of) $D^bCoh( Y)$ embeds into $\mathcal {F}(X)$: we call this hypothesis “core homological mirror symmetry”. We prove that the embedding extends to an equivalence of categories, $D^{b}Coh(Y) \simeq D^{\pi }( \mathcal {F}(X))$, using Abouzaid’s split-generation criterion. The results only depend on certain formal properties of the Fukaya category, which have been established in certain cases but not in complete generality. The appendix, which can be read on its own, proves a result about Hochschild cohomology for schemes: the compatibility of the global Hochschild–Kostant–Rosenberg isomorphism with Kodaira–Spencer deformation theory.
Phenotypes, genotypes and breakpoints: an assessment of β-lactam/β-lactamase inhibitor combinations against OXA-48
Authors: Asempa Tomefa E , Kois Abigail K , Gill Christian M , Nicolau David P 
Published: January 2023

Abstract

Background
Two of the three recently approved β-lactam agent (BL)/β-lactamase inhibitor (BLI) combinations have higher CLSI susceptibility breakpoints (ceftazidime/avibactam 8 mg/L; meropenem/vaborbactam 4 mg/L) compared with the BL alone (ceftazidime 4 mg/L; meropenem 1 mg/L). This can lead to a therapeutic grey area on susceptibility reports depending on resistance mechanism. For instance, a meropenem-resistant OXA-48 isolate (MIC 4 mg/L) may appear as meropenem/vaborbactam-susceptible (MIC 4 mg/L) despite vaborbactam’s lack of OXA-48 inhibitory activity.

Methods
OXA-48-positive (n = 51) and OXA-48-negative (KPC, n = 5; Klebsiella pneumoniae wild-type, n = 1) Enterobacterales were utilized. Susceptibility tests (broth microdilution) were conducted with ceftazidime/avibactam, imipenem/relebactam and meropenem/vaborbactam, as well as their respective BL partner. Antimicrobial activity of all six agents was evaluated in the murine neutropenic thigh model using clinically relevant exposures. Efficacy was assessed as the change in bacterial growth at 24 h, compared with 0 h controls.

Results
On average, the three BL/BLI agents resulted in robust bacteria killing among OXA-48-negative isolates. Among OXA-48-positive isolates, poor in vivo activity with imipenem/relebactam was concordant with its resistant phenotypic profile. Variable meropenem/vaborbactam activity was observed among isolates with a ‘susceptible’ MIC of 4 mg/L. Only 30% (7/23) of isolates at meropenem/vaborbactam MICs of 2 and 4 mg/L met the ≥1-log bacterial reduction threshold predictive of clinical efficacy in serious infections. In contrast, ceftazidime/avibactam resulted in marked bacterial density reduction across the range of MICs, and 96% (49/51) of isolates exceeded the ≥1-log bacterial reduction threshold.

Conclusions
Data demonstrate that current imipenem/relebactam and ceftazidime/avibactam CLSI breakpoints are appropriate. Data also suggest that higher meropenem/vaborbactam breakpoints relative to meropenem can translate to potentially poor clinical outcomes in patients infected with OXA-48-harbouring isolates.
Pure Mucinous Carcinoma of the Breast: Radiologic-Pathologic Correlation
Authors: Kuzmiak Cherie M , Calhoun Benjamin C 
Published: January 2023

AbstractMucinous carcinoma (MC) of the breast is a rare, specialized subtype of invasive breast carcinoma (IBC) accounting for approximately 1% to 4% of all primary breast malignancies. Mucinous carcinoma occurs predominantly in patients who are postmenopausal or elderly. It is usually detected on screening mammography, but occasionally the patient may present with a palpable mass. The most common mammographic appearance is an equal to high density, oval or round mass with circumscribed or indistinct margins; MC can mimic a benign lesion. Histologically, MC is a well-differentiated cancer characterized by pools of mucin around neoplastic cells. Depending on mucin content, the tumor is classified as pure (≥90% mucin) or mixed (&gt;10% and &lt;90% mucin). Pure MCs (PMCs) are of low or intermediate nuclear grade, and the vast majority are hormone receptor–positive and human epidermal growth factor-2 receptor–negative (luminal A subtype). Pure MCs may be classified as hypocellular (type A) or hypercellular (type B) and have a lower rate of axillary lymph node involvement and more favorable prognosis than IBCs, no special type. The purpose of this article is to review the clinical features, imaging appearances, associated histopathology, and management of PMC.
Probabilistic framework for reliable optimal design of gearboxes in general-purpose industrial robots considering random use conditions
Authors: Park Jin-gyun , Yoon Heonjun , Youn Byeng D 
Published: January 2023

AbstractA vertically articulated robot with 6-degrees of freedom (DoF), called a general-purpose robot, can perform a myriad of different tasks within a workspace. This paper newly presents a probabilistic framework for the reliable optimal design of gearboxes used in general-purpose industrial robots, which considers random use conditions. To account for random use conditions, the start and end positions of a single motion profile are described as the random variable, which is statistically modeled as a uniform distribution based on the assumption that we have no information about the robot use pattern. Then, each sample of the random variable is converted to the corresponding motion profile by using an on-line trajectory planner. Monte Carlo simulation is implemented for the uncertainty propagation analysis, due to the heuristic feature of the on-line trajectory planner. In the design optimization formulation, the peak torque constraint and maximum bending moment constraint are described in a probabilistic manner. The system-level lifetime is calculated by combining component scale factors. The effectiveness of the proposed framework is demonstrated by examining a case study of a gearbox size problem for a 6-DoF serial industrial robot. The benefits of this study are as follows: Firstly, the proposed framework can evaluate the performance considering random use conditions. Secondly, torque reliability and bending moment reliability are newly proposed to ensure the dynamic performance of an industrial robot. Thirdly, the system-level lifetime by combining component scale factors gives more user-oriented and intuitive measure in an industrial robot design.
A One-Step Multiplex PCR Method to Rapidly Distinguish Two Strains of Diglyphus wani (Hymenoptera: Eulophidae) Against Agromyzid Leafminers
Authors: Du Su-Jie , Xu Shi-Yun , Guo Jian-Yang , Ye Fu-Yu , Wan Wei-Jie , Liu Wan-Xue 
Published: January 2023

Abstract
Hymenopteran parasitoids generally show a haplo-diploid sex determination system. Haploid males are produced from unfertilized eggs, whereas diploid females develop from fertilized eggs (arrhenotokous). In some cases, diploid females develop from unfertilized eggs (thelytokous). Diglyphus wani (Hymenoptera: Eulophidae) is a biological control agent for agromyzid leafminers and have arrhenotokous and thelytokous strains. However, the morphological characteristics of two strains of D. wani are so similar that it is difficult to accurately distinguish them based on morphology. Here, a rapid molecular identification method was developed based on the mitochondrial gene cytochrome c oxidase I (COI) and one-step multiplex PCR. Two primer combinations, PC1 (Ar-F1/Th-F1/WR2) and PC2 (Ar-F1/Th-F4/WR2), were designed and repeatedly screened to distinguish two strains simultaneously, of which two special forward primers Th-F1/Th-F4 were used for the thelytokous strain and one special forward primer Ar-F1 was used for the arrhenotokous strain. In addition, a common reverse primer, WR2, was used for both strains. The PC1 and PC2 PCR assays were effective in distinguishing the two strains at different developmental stages and field colonies. This method provides a reliable, highly sensitive, and cost-effective tool for the rapid identification of the two strains of D. wani.
Quality-of-life outcomes and risk prediction for patients randomized to nivolumab plus ipilimumab vs nivolumab on LungMAP-S1400I
Authors: Unger Joseph M , Qian Lu , Redman Mary W , Tavernier Susan S , Minasian Lori , Sigal Ellen V , Papadimitrakopoulou Vassiliki A , Leblanc Michael , Cleeland Charles S , Dzingle Samuel A , Summers Thomas J , Chao Herta , Madhusudhana Sheshadri , Villaruz Liza , Crawford Jeffrey , Gray Jhanelle E , Kelly Karen L , Gandara David R , Bazhenova Lyudmila , Herbst Roy S , Gettinger Scott N , Moinpour Carol M 
Published: January 2023

AbstractBackgroundAn important issue for patients with cancer treated with novel therapeutics is how they weigh the effects of treatment on survival and quality of life (QOL). We compared QOL in patients enrolled to SWOG S1400I, a substudy of the LungMAP biomarker-driven master protocol.MethodsSWOG S1400I was a randomized phase III trial comparing nivolumab plus ipilimumab vs nivolumab for treatment of immunotherapy-naïve disease in advanced squamous cell lung cancer. The primary endpoint was the MD Anderson Symptom Inventory–Lung Cancer severity score at week 7 and week 13 with a target difference of 1.0 points, assessed using multivariable linear regression. A composite risk model for progression-free and overall survival was derived using best-subset selection.ResultsAmong 158 evaluable patients, median age was 67.6 years and most were male (66.5%). The adjusted MD Anderson Symptom Inventory–Lung Cancer severity score was 0.04 points (95% confidence interval [CI] = −0.44 to 0.51 points; P = .89) at week 7 and 0.12 points (95% CI = −0.41 to 0.65; P = .66) at week 13. A composite risk model showed that patients with high levels of appetite loss and shortness of breath had a threefold increased risk of progression or death (hazard ratio [HR] = 3.06, 95% CI = 1.88 to 4.98; P &lt; .001) and that those with high levels of both appetite loss and work limitations had a fivefold increased risk of death (HR = 5.60, 95% CI = 3.27 to 9.57; P &lt; .001)—compared with those with neither risk category.ConclusionsWe found no evidence of a benefit of ipilimumab added to nivolumab compared with nivolumab alone for QOL in S1400I. A risk model identified patients at high risk of poor survival, demonstrating the prognostic relevance of baseline patient-reported outcomes even in those with previously treated advanced cancer.
Bilateral Tessier no. 7 cleft with an accessory maxilla and osseous choristoma: a case report
Authors: Acevedo Fernando Miguel Almaguer , Doe Ketemepi Gabriel Victor , Hernandez Barbara Yordanis , Lambert Radisnay Guzman , Lopez Duniesky Martinez , Gonzalez Mariuska Rodriguez 
Published: January 2023

Abstract
Tessier no. 7 clefts are characterized by macrostomia, facial muscular diastasis and maxillary and zygomatic bone abnormalities. It is caused by a lack of ectomesenchyme formation or penetration of the maxillary and mandibular processes during the fourth and fifth weeks of development. A case of bilateral transverse facial cleft with an accessory maxilla and an osseous choristoma is presented. The diagnosis of accessory maxilla was based on clinical findings due to the inaccessibility of orthopantomography and computed tomography scan. Orbicularis oris muscle reconstruction, cheiloplasty and excision of accessory maxilla were done. Histopathological examination of the bony lesion showed an osseous choristoma. There were no postoperative complications or local recurrence of the lesion excised. This case report demonstrates the importance of early diagnosis and intervention in maxillofacial congenital anomalies. Cheiloplasty restores function and gives the patient a natural appearance. The excision of accessory bone prevents further complications in the child’s growth.
A complex surgery of spinal tuberculosis with a psoas abscess accompanied by fibula autografting: an alternative treatment of Pott’s disease
Authors: Mansour Marah , Tanta Nour , Ismail Ghina , Alsuliman Tamim , Salman Issam 
Published: January 2023

Abstract
The most common manifestation of skeletal tuberculosis is tuberculosis spondylitis. Symptoms may progress insidiously from back pain to cause many severe complications. Early diagnosis and management of spinal tuberculosis have special importance in prevention. We report a case of a 24-year-old female who was diagnosed with tuberculous spondylitis, complicated with psoas abscess and grade 1/5 of lower limb weakness. The patient was treated with anti-tuberculous drugs and underwent surgical debridement, interbody fusion and internal fixation accompanied by fibular autografting using a posterior-only approach and supplemental posterior spinal stabilisation on an infected background. Within 14 years of follow-up, full bone graft spinal fusion has been achieved with no major complications. According to its clinical efficacy and feasibility, this procedure is suggested to be an alternative treatment for Pott’s disease.
Unexpected long-term survival of Stage IV pancreatic cancer patient with synchronic liver metastases after multimodal therapy including upfront surgery
Authors: Obed Aiman , Siyam Mahmoud , Jarrad Amr Anwar , Abdelhadi Ody , Ababneh Muaweih , Annab Hassan , Füzesi Laszlo , Bashir Abdalla , Jarrad Anwar 
Published: January 2023

Abstract
We report the case of a 56-year-old male with pancreatic cancer and 25 liver metastases. The patient underwent a distal pancreatectomy with 11 metastasectomies in the left liver lobe. Histological examination demonstrated a moderately differentiated ductal adenocarcinoma with pT3N0M1, Stage IVb. Three weeks later, we performed transarterial chemoembolization for the right lobe of the liver, and after 6 weeks we started systemic chemotherapy with FOLFIRINOX. After 31 months, computer tomography examination showed increases in size of the remaining lesions at segment VII/VIII of the right lobe. All liver metastases were surgically removed and a new chemotherapy was initiated. Nevertheless, after 40 months the patient developed two brain metastases. One was surgically resected and the smaller lesion was treated by gamma knife. Unfortunately, the patient died 42 months after the first presentation. Conclusively, in very selected patients with synchronic liver metastasis, multimodal treatment including repeated surgery, TACE and chemotherapy may prolong survival.
A statistical analysis of the catalogues and criticism of the 19th-century Paris Fine Art Salon: The emergence of titling in the French art world
Authors: Bowman Mike 
Published: January 2023

Abstract
The dominant institution in the French art world for the display of new art for most of the 19th century was the Paris Salon. Artistic reputations depended upon showing works at the Salon, and critics made their names through writing about the event. In this article, statistical analysis of the contents and structure of the catalogues of the Salon and of Salon criticism is utilized to understand how the practice of titling new paintings emerged and was adopted in the 19th-century French art world. My work shows how statistical methods can be used to investigate practical and conceptual change, and problematizes accounts of the emergence of titling given by earlier authors. There are also methodological lessons for those working in the digital humanities from the approach adopted in this article.
Comparison of virulence factors and susceptibility profiles of Malassezia furfur from pityriasis versicolor patients and bloodstream infections of preterm infants
Authors: Rhimi Wafa , Chebil Wissal , Ugochukwu Iniobong Chukwuebuka Ikenna , Babba Hamouda , Otranto Domenico , Cafarchia Claudia 
Published: January 2023

Abstract
In spite of the increasing medical interest in Malassezia yeasts, the virulence factors of Malassezia furfur causing bloodstream infections (BSI) were never investigated. Therefore, phospholipase (Pz), lipase (Lz), hemolysin (Hz), biofilm production, and in vitro antifungal susceptibility profiles were evaluated in M. furfur strains, isolated from both pityriasis versicolor (PV) patients (n = 18; Group 1) or from preterm infants BSI (n = 21; Group 2). All the test stains exhibited Pz activity, whereas 92.3% and 97.4% of strains exhibited Lz and Hz activities, respectively. Pz, Lz, and Hz activities were higher (i.e., lower values) within Group 1 strains (i.e., 0.48, 0.40, and 0.77) than those within Group 2 (i.e., 0.54, 0.54, and 0.81). The biofilm production was higher within Malassezia isolates from Group 2 (0.95 ± 0.3) than from Group 1 (0.72 ± 0.4). Itraconazole and posaconazole were the most active drugs against M. furfur, followed by amphotericin B and fluconazole. The minimum inhibitory concentrations (MIC) values varied according to the origin of M. furfur strains being statistically lower in M. furfur from Group 1 than from Group 2. This study suggests that M. furfur strains produce hydrolytic enzymes and biofilm when causing PV and BSI. Data show that the phospholipase activity, biofilm production, and a reduced antifungal susceptibility profile might favor M. furfur BSI, whereas lipase and hemolytic activities might display a synergic role in skin infection.
Vortex weighing and dating of planets in protoplanetary discs
Authors: Rafikov Roman R , Cimerman Nicolas P 
Published: January 2023

ABSTRACT
High-resolution sub-mm observations of some protoplanetary discs reveal non-axisymmetric features, which can often be interpreted as dust concentrations in vortices that form at the edges of gaps carved out by the embedded planets. We use recent results on the time-scale for the planet-driven vortex development in low-viscosity discs to set constraints on the mass and age of a planet producing the vortex. Knowledge of the age of the central star in a vortex-bearing protoplanetary disc system allows one to set a lower limit on the planetary mass at the level of several tens of M⊕. Also, an independent upper limit on the planetary mass would constrain the planetary age, although given the current direct imaging detection limits this constraint is not yet very stringent (it is also sensitively dependent on the disc scale height). These results can be extended to account for the history of planetary mass accretion if it is known. We apply our calculations to several protoplanetary discs harbouring vortex-like features as revealed by ALMA and set limits of (30–50) M⊕ (for disc aspect ratio of 0.1) on the minimum masses of putative planets that could be responsible for these vortices. Our vortex-based method provides an independent way of constraining the properties of embedded planets, complementary to other approaches.
Characterizing line-of-sight variability of polarized dust emission with future CMB experiments
Authors: McBride Lisa , Bull Philip , Hensley Brandon S 
Published: January 2023

ABSTRACT
While Galactic dust emission is often accounted for in cosmic microwave background (CMB) analyses by fitting a two-parameter modified blackbody (MBB) model in each pixel, typically a number of such clouds are found along each line of sight and within each angular pixel, resulting in a superposition of their spectra. We study the effects of this superposition on pixel-based foreground fitting strategies by modeling the spectral energy distribution (SED) in each pixel as the integral of individual MBB spectra over various physically motivated statistical distributions of dust cloud properties. We show that fitting these SEDs with the two-parameter MBB model generally results in unbiased estimates of the CMB Stokes Q and U amplitudes per pixel, unless there are significant changes in both the dust SED and polarization angle along the line of sight, in which case significant (&gt;10σ) biases are observed in an illustrative model. We find that the best-fitting values of the dust temperature, Td, and spectral index, βd, are significantly biased from the mean/median of the corresponding statistical distributions when the distributions are broad, suggesting that MBB model fits can give an unrepresentative picture of the physical properties of dust at microwave wavelengths if not interpreted carefully. Using Fisher matrix analysis, we determine the experimental sensitivity required to recover the parameters of the Td and βd distributions by fitting a probabilistic MBB model, finding that only the parameters of broad distributions can be measured by SED fitting on a single line of sight.