bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between depressed affect, parental monitoring, and sex on cannabis use among American Indian youth
Authors: Haruyama Dorothy , Prince Mark A. , Swaim Randall C. , Chavez Ernest L. 
Published: March 2023

AbstractBackground and ObjectivesAmerican Indian (AI) adolescents report higher rates of cannabis use than national US adolescents. Previous study examined interactive relationships between depressed affect and family factors on AI adolescent alcohol use. These factors have not been investigated for cannabis use. We examined whether parental monitoring dampened risk for cannabis use due to depressed affect, and potential moderation by sex.MethodsWe measured cannabis use, depressed affect, parental monitoring, and sex among reservation area AI youth among students in grades 7–12 attending 45 schools. We used censor‐inflated regression models to identify parental monitoring as a moderator of the relationship between depressed affect and cannabis use.ResultsIn the logistic portion of censor‐inflated models, level of depressed affect and parental monitoring significantly related to last 30‐day cannabis use. Higher levels of parental monitoring at lower levels of depressed affect related to lower likelihood of cannabis use. Female students had greater likelihood of endorsing cannabis use at higher levels of depressed affect. In the linear portion of the censor‐inflated regression models, sex and level of parental monitoring significantly related to cannabis use frequency. Male students endorsed more frequent cannabis use while higher levels of parental monitoring related to lower frequency of use.Discussion and ConclusionsParental monitoring may dampen the effect of depressed affect on cannabis use among AI youth on reservations.Scientific SignificanceFuture interventions should foster skill‐building prevention efforts directed at coping with depression, along with parental training for effective monitoring. Special attention to AI female adolescents may be indicated.
Opioid use disorder at delivery hospitalization in the United States: 2012–2016
Authors: Malhotra Tani , Sheyn David , Arora Kavita S. 
Published: March 2023

AbstractBackground and ObjectivesThe objective of this paper is to evaluate national trends, socioeconomic risk factors, and maternal and obstetric outcomes for patients with and without opioid use disorder (OUD) at delivery hospitalization.MethodsThis is a retrospective cohort using the National Inpatient Sample 2012–2016 of 3,554,477 deliveries to analyze trends in OUD in patients at delivery hospitalization. We conducted univariable and multivariable logistic regression to compare clinical, demographic, hospital, and geographic associations for patients with OUD during delivery hospitalization.ResultsThe incidence of OUD at delivery hospitalization increased from 4.48 per 1000 deliveries in 2012 to 7.67 in 2016. The highest rate of OUD was in the Northeast and the lowest in the West (9.29 vs. 4.13 per 1000, respectively, p < .001). After adjusting for confounders, history of concurrent cocaine use (adjusted odds ratio [aOR] = 5.95, 95% confidence interval [CI]: 5.38–6.59), sedative use (aOR = 17.28, 95% CI: 14.71–20.31), and amphetamine use (aOR = 4.05, 95% CI: 3.71–4.43), were strongly associated with OUD. Additionally, hepatitis C infection, (aOR = 21.98, 95% CI: 20.89–23.11), white race (aOR = 3.12, 95% CI: 3.00–3.24), and public insurance (aOR = 3.92, 95% CI: 3.77–4.08) were also associated with OUD.Discussion and ConclusionThe continued increase in rates of OUD at delivery hospitalization and its association with adverse perinatal outcomes highlights the need for universal screening and resource allocation for programs directed toward pregnant people.Scientific SignificanceOur study builds upon the prior literature that reports trends in OUD at delivery hospitalization from 1998 to 2011 as well as presents a more in‐depth look at risk factors and adverse pregnancy outcomes than previously reported.
Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?
Authors: Annesi‐Maesano Isabella , Cecchi Lorenzo , Biagioni Benedetta , Chung Kian Fan , Clot Bernard , Collaud Coen Martine , D'Amato Gennaro , Damialis Athanasios , Dominguez‐Ortega Javier , Galàn Carmen , Gilles Stefanie , Holgate Stephen , Jeebhay Mohamed , Kazadzis Stelios , Papadopoulos Nikolaos G. , Quirce Santiago , Sastre Joaquin , Tummon Fiona , Traidl‐Hoffmann Claudia , Walusiak‐Skorupa Jolanta , Alonso‐Coello Pablo , Canelo‐Aybar Carlos , Cantero‐Fortiz Yahveth , Rigau David , Salazar Josefina , Verdugo‐Paiva Francisca , Jutel Marek , Akdis Cezmi A. , Agache Ioana 
Published: March 2023

AbstractLimited number of studies have focused on the impact of pollen exposure on asthma. As a part of the EAACI Guidelines on Environment Science, this first systematic review on the relationship of pollen exposure to asthma exacerbations aimed to bridge this knowledge gap in view of implementing recommendations of prevention. We searched electronic iPubMed, Embase, and Web of Science databases using a set of MeSH terms and related synonyms and identified 73 eligible studies that were included for systemic review. When possible, meta‐analyses were conducted. Overall meta‐analysis suggests that outdoor pollen exposure may have an effect on asthma exacerbation, but caution is needed due to the low number of studies and their heterogeneity. The strongest associations were found between asthma attacks, asthma‐related ED admissions or hospitalizations, and an increase in grass pollen concentration in the previous 2‐day overall in children aged less than 18 years of age. Tree pollen may increase asthma‐related ED visits or admissions lagged up to 7‐day overall in individuals younger than 18 years. Rare data show that among subjects under 18 years of age, an exposure to grass pollen lagged up to 3 days may lower lung function. Further research considering effect modifiers of pollen sensitization, hay fever, asthma, air pollution, green spaces, and pre‐existing medications is urgently warranted to better evaluate the impacts of pollen on asthma exacerbation. Preventive measures in relation to pollen exposure should be integrated in asthma control as pollen increase continues due to climate change.
Evaluating antenatal risk in twin pregnancies—A feasibility study to identify modifiable factors associated with adverse pregnancy outcomes
Authors: Greatholder Isabelle , Tomlinson Emma , Wilkinson Jack , Higgins Lucy E. , Kilby Mark D. , Heazell Alexander E. P. 
Published: March 2023

AbstractIntroductionTwin pregnancies have significantly higher rates of perinatal morbidity and mortality compared to singleton pregnancies; current attempts to reduce perinatal mortality have been less successful in twin pregnancies. The paucity of information about modifiable risk factors for adverse neonatal outcomes in twin pregnancies, as well as independent effects of chorionicity may have contributed to this outcome. This study aimed to explore the feasibility of an observational study to identify modifiable factors associated with adverse neonatal outcomes in twin pregnancies.Material and methodsPatients pregnant with twins at six UK hospitals between December 2019–March 2021 completed researcher‐administered questionnaires at approximately 20‐, 28‐ and 36‐weeks' gestation, recording a wide range of self‐reported social, lifestyle and demographic factors, alongside prospectively recorded clinical data from maternity records. Descriptive statistics were used to describe frequencies of exposures; logistic regression was used to determine whether factors were associated with a composite measure of adverse neonatal outcome.ResultsData were collected from 65% (181/277) of eligible participants. A total of 98% (175) of participants had positive views about their participation. Some exposures, including cigarette smoking, supine sleep position and reduced fetal movements were less frequent in twin pregnancies compared to singletons, whereas fertility treatment was more common. Furthermore, different patterns of exposure were seen between monochorionic and dichorionic twins. This pilot study found some associations with adverse neonatal outcomes including: low BMI (OR 8.36, 95% CI: 1.02–68.87), maternal age ≥41 years (OR 9.0 95% CI: 1.07–75.84), maternally perceived high‐stress levels (OR 1.96, 95% CI: 1.03–3.75) and inadequate antenatal screening (OR 1.44, 95% CI: 1.01–2.06). Sleep duration ≥9 h and right‐sided going to sleep position were more frequent among pregnancies with adverse outcomes. Participants who reported receiving no information on fetal movement and reduced maternal perception of movements were more likely to have an adverse outcome, but sample size prohibited analysis based upon chorionicity.ConclusionsAn observational study of modifiable factors in twin pregnancy is feasible. Differences in the frequencies of exposures between twin and singleton pregnancies highlight the need for twin‐specific studies to identify modifiable factors and develop preventative strategies for morbidity and mortality in twin pregnancies.
SARS‐CoV‐2 placentitis and severe pregnancy outcome after maternal infection: A Danish case series
Authors: Nielsen Stine Y. , Hvidman Lone E. , Aabakke Anna J. M. , Olsen Tina E. , Johnsen Iben B. G. , Bogaard Pauline W. , Petersen Astrid , Westergaard Hanne B. , Sørensen Anne , Hedermann Gitte , Rønneberg Elisabeth T. , Thisted Dorthe , Boris Jane , Andersen Lise L. T. , Eggers Anne G. H. , Lindved Birgitte F. , Henriksen Tine B. 
Published: March 2023

AbstractIntroductionSARS‐CoV‐2 infection during pregnancy may cause viral inflammation of the placenta, resulting in fetal demise even without fetal or newborn infection. The impact of timing of the infection and the mechanisms that cause fetal morbidity and mortality are not well understood.Material and methodsTo describe placental pathology from women with confirmed SARS‐CoV‐2 infection during pregnancy, a SARS‐CoV‐2 immunohistochemistry‐positive placenta and late miscarriage, stillbirth, neonatal death, or medically indicated birth due to fetal distress.ResultsThe triad of trophoblastic necrosis, inflammatory intervillous infiltrates, and increased perivillous fibrinoid deposition was present in all 17 placentas; the pregnancies resulted in eight stillbirths, two late miscarriages (19 and 21 weeks’ gestation), and seven liveborn children, two of which died shortly after delivery. The severity of maternal COVID‐19 was not reflected by the extent of the placental lesions. In only one case, SARS‐CoV‐2 was detected in lung tissue samples from the fetus. The majority events (miscarriage, stillbirth, fetal distress resulting in indicated birth, or livebirth, but neonatal death) happened shortly after maternal SARS‐CoV‐2 infection was diagnosed. Seven of eight sequenced cases were infected with the Delta (B.1.617.2) virus strain.ConclusionWe consolidate findings from previous case series describing extensive SARS‐CoV‐2 placentitis and placental insufficiency leading to fetal hypoxia. We found sparse evidence to support the notion that SARS‐CoV‐2 virus had infected the fetus or newborn.
Risk of obstetric and perinatal complications in women presenting with breast cancer during pregnancy and the first year postpartum in Sweden 1973–2017: A population‐based matched study
Authors: Lundberg Frida E. , Gkekos Leo , Rodriguez‐Wallberg Kenny A. , Fredriksson Irma , Johansson Anna L. V. 
Published: March 2023

AbstractIntroductionFor women presenting with breast cancer during pregnancy, treatment guidelines were historically restricted to only surgical treatment. Over the past decades, chemotherapy administered during pregnancy has been gradually introduced. Although breast cancer treatments during ongoing pregnancy have been deemed safe, detailed information on potential obstetric risks is lacking. We aimed to assess the risk of adverse obstetric and perinatal outcomes of breast cancer in pregnancy and within 1 year postpartum and in relation to trimester at breast cancer diagnosis, tumor stage, and cancer treatment during pregnancy.Material and methodsPopulation‐based matched study. Women diagnosed with breast cancer during pregnancy in 1973–2017 were identified in the Swedish Cancer Register and the Medical Birth Register, with additional information from the National Quality Register for Breast Cancer. Each birth with maternal breast cancer (n = 208 pregnant, n = 672 postpartum) was matched by age, calendar year, and birth order to 10 unexposed births from cancer‐free women in the population (n = 2080 and n = 6720). Adjusted conditional logistic and multinomial regression models were used to estimate odds ratios and relative risk ratios, commonly denoted relative risks (RR) with 95% confidence intervals (CI), of adverse obstetric and perinatal outcomes.ResultsBreast cancer during pregnancy was associated with higher risks of preterm birth, both planned (RR 67.1, 95% CI 33.2–135.6) and spontaneous preterm birth (RR 3.8, 95% CI 2.0–7.5), and low birthweight (<2500 g: RR 7.5, 95% CI 4.9–11.3). The associated risks were higher if the breast cancer was diagnosed in the second trimester, and of similar magnitude irrespective of stage and treatment groups. There was a higher risk of low birthweight for gestational age (<25th centile) if breast cancer was diagnosed in the first trimester (RR 2.8, 95% CI 1.1–7.3). Risks of other pregnancy complications were similar to those of unexposed women, as were risks of neonatal mortality and malformations. Postpartum breast cancer was only associated with bleeding during pregnancy (RR 1.6, 95% CI 1.0–2.8).ConclusionsPreterm birth and related adverse outcomes were more common in women diagnosed with breast cancer during pregnancy. Reassuringly, breast cancer was not associated with other maternal pregnancy complications or adverse outcomes in children.
Postural balance under sensory manipulation predicted fine and gross motor skills in children from 5 to 6 years of age
Authors: Mnejja Khouloud , García‐Soidan Jose Luis , Romo‐Perez Vicente , Sahli Sonia 
Published: March 2023

AbstractAimOur aim was to identify predictors of fine and gross motor skills at 5–6 years of age using postural balance under sensory manipulation.MethodsThis study was conducted during the 2021–2022 academic year and focused on 112 children from three preschools in Tunisia, with roughly the same socio‐economic status. Postural balance was assessed with their eyes open and closed on both firm and foam surfaces and motor skills were measured using the short version of Bruininks–Oseretsky Test of Motor Proficiency, Second Edition (Bot‐2). Multiple linear regression analysis with stepwise backward selection was used to find a simplified model that best explained the data.ResultsPostural balance accounted for 11% of the total variation in fine motor skills, except for the eyes open firm condition, 10% of the gross motor skills and about 14% of the total Bot‐2 score. The eyes open foam condition was the only significant contributor to the gross motor skills model and the overall motor score.ConclusionAssessing postural balance assessment at 5–6 years of age may predict motor skills. It may be useful for monitoring early child development and designing physical activity programmes for this age group.
Letter: be careful of gastrointestinal CMV infection in adverse events from ICIs therapy in solid tumours
Authors: Parente Paola , Ascani Stefano , Maiorano Brigida Anna , Zanelli Magda , Ciardiello Davide 
Published: March 2023

LINKED CONTENTThis article is linked to Dahl et al papers. To view these articles, visit https://doi.org/10.1111/apt.17201 and https://doi.org/10.1111/apt.17431
Childhood trauma and cognitive functioning in mood disorders: A systematic review
Authors: Barczyk Zoe A. , Foulds James A. , Porter Richard J. , Douglas Katie M. 
Published: March 2023

AbstractBackgroundCognitive impairment is a core feature of mood disorders and has been identified as an important treatment target. A better understanding of the factors contributing to cognitive impairment in mood disorders would be beneficial in developing interventions to address cognitive impairment. One key factor is childhood trauma. The aim of this review was to systematically synthesise and review research examining associations between reported childhood trauma and cognitive functioning in mood disorders.MethodsStudies in adult samples examining the relationship between objective cognitive function and reported childhood trauma in major depressive disorder and/or bipolar disorder (in‐episode or euthymia) were identified. Searches were conducted on PubMed, Embase and PsycINFO until January 2022. A narrative review technique was used due to the heterogeneity of group comparisons, cognitive tests and data analysis across studies.ResultsSeventeen studies met the criteria for inclusion (mood disorders N = 1723, healthy controls N = 797). Evidence for childhood trauma being related to poorer cognitive functioning was consistent across global cognitive functioning and executive function domains for euthymic patients and psychomotor speed for in‐episode patients. There was mixed evidence for verbal learning and memory and executive function for in‐episode patients. Identification of patterns within other domains was difficult due to limited number of studies.ConclusionFindings from this review suggest childhood trauma is associated with poorer cognitive functioning in people with mood disorders. Targeted interventions to improve cognition may be warranted for this group.
Does performance persistence below aspirations affect firms' accounting information disclosure strategies? An empirical study based on reliability and comparability
Authors: Zhong Xi , Ren Liuyang , Ren Ge 
Published: March 2023

AbstractIntegrating the behavioral theory of the firm and agency theory, this study is the first to examine the antecedents of firms' choice to disclose low‐quality accounting information from the perspective of performance persistence below aspirations. Based on empirical data of 31,326 firm‐annual observations involving 3584 listed companies for the 2007–2021 period, we find that firms actively reduce accounting information reliability and comparability in the presence of performance persistence below aspirations. Furthermore, we find that CEO‐CFO surname ties enhance the negative effect of performance persistence below aspirations on accounting information comparability. Finally, we find that agency costs play a mediating role in the relationship that performance persistence below aspirations has with accounting information reliability and comparability. This study is the first to examine performance persistence below aspirations and accounting information reliability and comparability. Meanwhile, this study provides important insights for policymakers to improve the quality of capital market information and for shareholders to improve the quality of corporate governance.
Clinical heterogeneity of NADSYN1‐associated VCRL syndrome
Authors: Aubert‐Mucca Marion , Janel Caroline , Porquet‐Bordes Valérie , Patat Olivier , Touraine Renaud , Edouard Thomas , Michot Caroline , Tessier Aude , Cormier‐Daire Valérie , Attie‐Bitach Tania , Baujat Geneviève 
Published: March 2023

AbstractThe NADSYN1 gene [MIM*608285] encodes the NAD synthetase 1 enzyme involved in the final step of NAD biosynthesis, crucial for cell metabolism and organ embryogenesis. Perturbating the role of NAD biosynthesis results in the association of vertebral, cardiac, renal, and limb anomalies (VCRL). This condition was initially characterized as severe with perinatal lethality or developmental delay and complex malformations in alive cases. Sixteen NADSYN1‐associated patients have been published so far. This study illustrates the wide phenotypic variability in NADSYN1‐associated NAD deficiency disorder. We report the clinical and molecular findings in three novel cases, two of them being siblings with the same homozygous variant and presenting with either a very severe prenatal lethal or a mild phenotypic form. In addition to an exhaustive literature, we validate the expansion of the spectrum of NAD deficiency disorder. Our findings indicate that NAD deficiency disorder should be suspected not only in the presence of the full spectrum of VCRL, but even a single of the aforementioned organs is affected. Decreased plasmatic levels of NAD should then strongly encourage the screening for any of the genes responsible for a NAD deficiency disorder.
Children's ages of consent to non‐urgent heart surgery: The views of two paediatric cardiology teams
Authors: Alderson Priscilla , Bellsham‐Revell Hannah , King Liz , Vigneswaran Trisha , Wray Jo 
Published: March 2023

AbstractPaediatric cardiology practitioners and related experts report unusually young ages when they begin to inform children about their non‐urgent heart surgery and begin to respect children's consent or refusal. Research methods included observations in two paediatric cardiology units, audio‐recorded interviews with 45 experts, and qualitative data analysis. Significantly younger ages were cited than are usually recommended in the clinical and legal literature. Interviewed practitioners took seriously children's consent to or refusal of a heart transplant from around 6 years, and a child's firm refusal of induction of anaesthesia from around 4 years, when surgery might be postponed.
Formal Models at the Core
Authors: Chemla Emmanuel , Charnavel Isabelle , Dautriche Isabelle , Embick David , Lerdahl Fred , Patel‐Grosz Pritty , Poeppel David , Schlenker Philippe 
Published: March 2023

AbstractThe grammatical paradigm used to be a model for entire areas of cognitive science. Its primary tenet was that theories are axiomatic‐like systems. A secondary tenet was that their predictions should be tested quickly and in great detail with introspective judgments. While the grammatical paradigm now often seems passé, we argue that in fact it continues to be as efficient as ever. Formal models are essential because they are explicit, highly predictive, and typically modular. They make numerous critical predictions, which must be tested efficiently; introspective judgments do just this. We further argue that the grammatical paradigm continues to be fruitful. Within linguistics, implicature theory is a recent example, with a combination of formal explicitness, modularity, and interaction with experimental work. Beyond traditional linguistics, the grammatical paradigm has proven fruitful in the study of gestures and emojis; literature (“Free Indirect Discourse”); picture semantics and comics; music and dance cognition; and even reasoning and concepts. We argue, however, that the grammatical paradigm must be adapted to contemporary cognitive science. Computational methods are essential to derive quantitative predictions from formal models (Bayesian pragmatics is an example). And data collection techniques offer an ever richer continuum of options, from introspective judgments to large‐scale experiments, which makes it possible to optimize the cost/benefit ratio of the empirical methods that are chosen to test theories.