bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Protein Losing Enteropathy after Fontan completion, a retrospective study from eight years’ experience in a growing high volume cardiac surgery center.
Authors: AbdelMassih Antoine Fakhry , Kiraly Laszlo , Badaoui Hazem El , Khan Mohammad , Hetharsi Balazs , Till Judit Noemi , Omelchenko Aleksandr , Salah Alaa Ziad , Jburi Farah Tarik Al , Alkhouli Laila , Taher Mina , Alhosani Najah , Youssef Omnia , Iqbal Sumaiya , Allami Zahraa , Jha Neerod Kumar , Hamad Eman Mahmoud , Omar Yasmin , AbdelRaouf Mohamed Mohamed , Khan Arshad , Azeez Zafar , Attia Michael , Mina Mariam , Ali Alyaa Al , Afifi Yara Khaled , Shershaby Meryam El , Musleh Afnan 
Published: May 2023

Abstract
Background:
Fontan procedure is the final stage of a three-stage palliation process in patients born with a univentricular heart as part of Hypoplastic Left Heart Syndrome (HLHS) or other types of Univentricular Heart. As essential as this procedure has proven to be for such cases, the Fontan physiology diminishes the cardiac output and expands systemic venous pressure which leads to venous congestion that can be complicated by Protein Losing Enteropathy (PLE). The aim of this retrospective research was to study the predictors of such complications in all patients who underwent completion of Fontan in our center in the past eight years. It involved the examination of medical records of patients who underwent completion of Fontan repair in our center since the inauguration of its cardiac surgery program. Exclusion criteria included the absence of any of the required predictors in a medical report. Included patients were divided into two groups: those who developed PLE and those who did not. For each group, the following data were collected: The degree of AV valve regurge, the ventricular functions, the invasive SVC, and pulmonary pressures before Fontan completion and the original cardiac diagnosis.
Results:
48 patients were included: only 13 developed PLE, accounting for 25% of the total patients. A multivariate regression analysis of the best predictors of the occurrence of PLE was the degree of AV valve regurge (P = 0.008), SVC mean pressure (P value = 0.01), and Ventricular functions (P value = 0.02). A ROC analysis was performed for each of the best predictors and showed that SVC pressure > 11 was 100% sensitive, moderate and severe regurge were 69% sensitive, and moderate to severe impairment of ventricular functions was 53% sensitive in predicting subsequent PLE.
Conclusion:
The unleashed findings might be game-changing in the decision-making of whether to complete the Fontan pathway or not in our growing cardiac surgery center, which is one of the largest in its respective region. The presence of moderate to severe AV valve regurge, moderate to severe ventricular dysfunction, and a Superior Vena caval pressure above 11 before Fontan completion should be regarded as contraindications to completion of the procedure.
Role of mir-554 and mir-3117 in trigger and develop Non-small cell lung cancer
Authors: Afshinpour Maral , Salimi Alireza 
Published: May 2023

Abstract
Background: Lung cancer is known as one of the most common cancers worldwide. Non-small cell lung cancer (NSCLC) is found in 85% of cases of lung cancer. In this study, we tried to identify genes that can be used to prevent cancer from progressing by inhibiting their expression by microRNAs. These gels can be targeted as a treatment.
Method: In this study, using the data obtained from the article, 37 genes were finally reached with the Venny 2.1 database. We then analyzed the genes involved in lung cancer, using databases such as DAVID, PANTHER, and ENRICHER.
Results: Our work provides insight into PDGFRA, LAMC1, and MAP3K8 have critical roles in important pathways and biological processes which can develop cancer such as; angiogenesis, integrin signaling pathway, and development process. for the first time, mir-554 and mir-3117plays a critical role by inhibiting the proto- oncogene genes map3k8, PDGFR and lamc1.
Systematic Study of Optoelectronic and Thermoelectric Properties of New Halide Double Perovskites Cs2TlBiX6 (X=Cl, Br and I) for Energy Harvesting Applications
Authors: Abdina Zain Ul , Qasim Irfan , Rashid Muhammad 
Published: May 2023

Abstract
In this study we preferred to substitute hybrid halide perovskites (CH3NH3PbI3) by using First principles calculations based on WEIN2K. To achieve renewable energy applications, the expansively investigate structured, optoelectronic, elastic, and thermoelectric characteristics of Cs2TlBiX6(X= Cl, Br, and I) double perovskite. The elastic properties in these investigations display ductile behavior. Direct band gaps (2.29 eV, 2.26 eV, and 1.63 eV) exhibited by Cs2TlBiX6 (X=Cl, Br and I) respectively. We have examined dielectric constants, refractive index, absorption coefficient, optical conductivity in optical properties. All compounds have high UV absorption coefficients, indicating that they are suitable for solar cells and other optical devices. In the temperature range of 200-800K, the thermoelectric and thermodynamic properties were calculated.
Parental uncertainty in plans and education of Ukrainian refugee children in European countries
Authors: Chovpan Ganna 
Published: May 2023

Abstract
In this paper we discuss two aspects. First, we show how uncertainty affects the experience of parents with temporary protection status, even in the case of sufficiently favorable mechanisms for integration into host society, immediate protection status, and substantial material support. Moreover, until now, refugee children have had no real working mechanism for continuing their education in the country of origin, which in itself is a phenomenon of modern educational technology. We want to show how distance education makes its own special and separate contribution to education strategy at a time of the greatest uncertainty in the plans of refugee parents. An anonymous survey was conducted among the parents of schoolchildren refugees. It was concluded that among those who are in a state of most significant uncertainty, there is the greatest desire to complete all possible strategies in education for their children. It is necessary to develop more flexible criteria for different groups of refugee children, depending on their age and their parents' plans to return home.
Goals for Adherence with Low-cost Incentives (GOALS): A protocol for a randomized controlled trial in Kampala, Uganda
Authors: Huang Haijing , Linnemayr Sebastian , Wagner Zachary , Mukasa Barbara , Onkundi Faith , Odiit Mary 
Published: May 2023

Abstract
Background:
Treatment outcomes of HIV-positive individuals are threatened by low antiretroviral therapy (ART) adherence, a problem that is particularly acute among youth. Incentives are a promising tool to support ART adherence, but traditional incentive designs rewarding uniformly high levels of the desired health behavior may demotivate those with low levels of the behavior. In this study, we investigate the effectiveness of alternative approaches to target-setting for incentive eligibility using subgoals (i.e. individual-specific, interim targets leading up to the optimal target).
Methods/Design:
We will enroll 628 HIV-positive youth between ages 15-30 into a 3-year randomized controlled trial. Participants will be randomized 1:1:1:1 to a control arm or one of three intervention arms (n=157 each) that allow them to enter a prize drawing for small incentives if their ART adherence meets the given goal. In the first arm (T1, assigned subgoal), goals will be externally assigned and adapted to their initial adherence level. In the second arm (T2, participatory subgoal), participants can set their own interim goals. In the third arm (T3, fixed goal), all participants must reach the same target goal of 90 percent adherence. T1 and T2 participants are required to reach 90% adherence by Month 12 to participate in a larger prize drawing. The control group receives the usual standard of care. All four groups will receive weekly motivational messages; the three treatment groups will additionally receive reminders of their upcoming prize drawing. Adherence will be measured continuously throughout the intervention period using electronic devices and for 12 months post-intervention. Surveys will be conducted at baseline and every 6 months. Viral loads will be measured annually. The primary outcome is Wisepill-measured adherence and a binary measure for whether the person took at least 90% of their pills. The secondary outcome is the log-transformed viral load as a continuous measure.
Discussion:
Our study is one of the first to apply insights about the psychology and behavioral economics of goal-setting to the design of incentives, by testing whether conditioning the eligibility threshold for incentives on subgoals (interim goals leading up to the ultimate, high goal) improves motivation and adherence more than setting a uniformly highly goal, and a comparison group.
Name of registration: ClinicalTrials.gov
Trial registration number: NCT05378607
Date of registration: May 18, 2022
URL of trial registry record: https://clinicaltrials.gov/ct2/show/NCT05378607
Usefulness of plasma and apolipoprotein B-depleted serum samples in paraoxonase 1 assessment
Authors: Kawaguchi Rina , Kemeda Takahiro , Yoshimoto Akira , Ohkawa Ryunosuke 
Published: May 2023

Abstract
Background: Paraoxonase 1 (PON1) is closely associated with the antioxidant, anti-inflammatory, and antiatherosclerotic functions of HDL. Although many clinical studies have evaluated the relationship between PON1 activity and various diseases, there are inconsistencies in sample preparation methods and substrate selection for PON1 analysis. Moreover, depending on the selected substrates, various types of PON1 activities can be measured, which would be an obstacle of dissemination of clinical practice. Here, we investigated differences between three PON1 activity types according to sample preparation procedures.
Methods: Samples were prepared from serum, plasma with or without calcium addition, HDL isolated by ultracentrifugation, and apolipoprotein B-depleted serum (BDS). Using these various sample types, PON1 protein concentration and activities using three substrate types (p-nitrophenyl acetate, paraoxon, and γ-thiobutyrolactone) were evaluated. PON1 distributions in HDL subfractions from serum and BDS samples were also investigated.
Results: PON1 activities in plasma were maintained by immediate calcium addition similar to those in serum, suggesting that plasma could be used for assessing PON1 instead of serum in which PON1 can be transported to apolipoprotein B-containing lipoproteins. In contrast, HDL isolated from plasma had significantly lower PON1 protein concentrations. PON1 activities, protein concentration, and distributions in BDS sample showed similar to those in serum samples than those in HDL sample.
Conclusions: This study revealed the advantages of using plasma with calcium addition and BDS as specimens that better reflect the in vivoenvironment for PON1 assessment. Focusing on each of three PON1 activity types might further enhance the clinical significance of PON1 testing.
Study of S Poisoning Mechanism on LaMnO3 Perovskite Catalyst Surface Based on DFT Method
Authors: Ren Dongdong , Wencong Hao , Wei Li , Pengyun Liu , Luo Siyi , Gui keting , Zuo Zongliang 
Published: May 2023

Abstract
The sulfur poisoning mechanism of low-temperature SCR de-NOx catalyst has always been one of the hot spots in academic circles. By studying the surface sulfur poisoning mechanism, low-temperature catalysts can be developed pertinently. In this paper, the mechanism of sulfur poisoning on the surface of LaMnO3 catalyst was studied by DFT theory, and the adsorption process of sulfur oxides on the surface and its influence on SCR reaction process, as well as the morphology and decomposition process of ammonium sulfate on the surface were calculated. The results show that sulfur oxides will be adsorbed on the surface and occupy the adsorption site, which will adversely affect the subsequent SCR reaction. At the same time, ammonium sulfate will accumulate on the catalyst surface, which will lead to sulfur poisoning.
Continental Complementarity of Renewable Energy Mixes
Authors: Worman Anders , Pechlivanidis Ilias , Uvo Cinita Bertacchi , Riml Joakim , Mewes Daniela 
Published: May 2023

Abstract
Intermittent weather and long-term periodic climate fluctuations cause large variations in renewable electricity production, which can require substantial amounts of energy storage to overcome energy drought periods. Fulfilling the energy storage demand is a key problem in ensuring renewable energy supply and is of great political concern to energy security across Europe. Here, based on a 35-year historical record of daily hydroclimatic data and information about existing hydropower, wind power and solar power systems covering the European continent, we reveal the strong complementarity inherent in the solar-wind-hydro energy components of the continental climate system. We show that the spatiotemporal management of renewable electricity production over the European continent can induce a Virtual Energy Storage Gain that is several times larger than the available energy storage capacity in hydropower reservoirs. The entire potential electricity production can precisely match the consumption by spatiotemporal management and using the present hydropower complemented by suitable shares of solar and wind power. While the mixed renewable energy potential varies less than anticipated at the continental scale, utilization of the complementarity requires new continental electrical transmission lines as well as stable international collaboration and trade. Hence, we highlight that management models need to consider incentives well beyond national boundaries to appropriately benefit from the covariances of continental climate conditions.
Dopant-assisted stabilization of negatively charged single nitrogen-vacancy centers in phosphorus-doped diamond at low temperatures
Authors: Shalomayeva Tetyana , Gryzlova Mariia , Mukherjee Amlan , Santonocito Santo , Dzhavadzade Dzhavid , Dasari Durga Bhaktavatsala Rao , Kato Hiromitsu , Stöhr Rainer , Denisenko Andrej , Mizuochi Norikazu , Wrachtrup Jörg , Geng Jianpei 
Published: May 2023

Abstract
Charge state instabilities have been a bottleneck for the implementation of solid-state spin systems and pose a major challenge to the development of spin-based quantum technologies. Here we investigate the stabilization of negatively charged nitrogen-vacancy (NV−) centers in phosphorus-doped diamond at liquid helium temperatures. Photoionization of phosphorous donors in conjunction with charge diffusion at the nanoscale enhances NV0 to NV− conversion and stabilizes the NV− charge state without the need for an additional repump laser. The phosphorus-assisted stabilization is explored and confirmed both with experiments and our theoretical model. Stable photoluminescence-excitation spectra are obtained for NV− centers created during the growth. The fluorescence is continuously recorded under resonant excitation to real-time monitor the charge state and the ionization and recombination rates are extracted from time traces. We find a linear laser power dependence of the recombination rate as opposed to the conventional quadratic dependence, which is attributed to the photo-ionization of phosphorus atoms.
Research progress of MOF/carbon nanocomposites on promoting ORR in microbial fuel cells cathode
Authors: Yu Shuyan , Guo Zhen , Zhou Yan , Li Congju 
Published: May 2023

Abstract
With the rapid development of economy, demand for energy is more urgent. Microbial fuel cells (MFCs) have the advantages of non-toxic, safety and environmental protection, and are considered as the ideal choice for the next generation of energy storage equipment. However, the slow kinetics of oxygen reduction reaction (ORR) on MFC air cathodes and the high cost of platinum (Pt) catalysts hinder their practical application, so there is a need to develop efficient, low-cost and stable electrocatalysts as alternatives. Recently, metal-organic framework (MOFs) has attracted wide attention in the field of electrocatalysis. Electrocatalysts prepared by the composite of MOFs and carbon nanomaterials have multiple advantages, such as adjustable chemical properties, high specific surface area and good electrical conductivity, which have been proved to be a promising electrocatalytic material. In this paper, the latest research progress of organic metal frames and carbon nanocomposites is reviewed, and the preparation methods and modification of MOFs and carbon nanofibers, carbon nanotubes and graphene composites are introduced respectively, as well as their applications in MFC cathode. Finally, the main challenges and prospects of MOFs/ carbon nanocomposite catalysts are put forward.
Analysis of the performance of carbon fiber patches on improving the failure strength of a damaged and repaired plate
Authors: Sebaibi Nour El Houda , Mhamdia Rachid , Kaddouri Nadia , Djabbar Safaa .CHahrazed , Madani Kouider , Campilho R.D.S.G. 
Published: May 2023

Abstract

Since the implementation of the composite patch bonding repair technique, this process has gradually replaced the traditional methods of bolting or welding. The correct choice of fiber type for the composite patch ensures better repair durability. Carbon fiber composites, which are preferred for the most advanced aeronautical and industrial applications, have shown great effectiveness in reducing stresses at the damaged area. They are chosen for their high strength, low weight, and high stiffness, compared to other fibers. This work consists of a finite element method to evaluate the performance of carbon fiber composite patches (high-modulus fiber and high-strength fiber) for load transfer and thus stress concentration reduction at the damaged area. The composite patches are bonded by the Adekit A-140 adhesive to repair an aluminum 2024-T3 plate. The geometric models for the study are a plate with a lateral crack and another plate with a crack emanating from a notch. The aim is to highlight the advantage of using high-modulus (HM) or high-strength (HS) carbon fibers to repair a plate with a variable stress concentration damaged area, and to assess the performance of different composites for variable crack lengths. The effects of crack size, the presence of a notch, the applied stress, and the use of a hybrid composite (combination of HM fibers and HS fibers) have been demonstrated.
Treatment With Auxin and Paclobutrazol Mediates Ros Regulation, Antioxidant Defence System and Cell Wall Response in Salt Treated Soybean
Authors: AYVACI Ufuk , KOC Fatma Nur , CETINKAYA Hatice , DINLER Burcu SECKIN 
Published: May 2023

Abstract
IAA and PBZ play important role in resisting abiotic stress for plants. However, the effects of combination of these regulators in plants under salinity remained obscure. In the current study, the role of 50 ppm IAA and 10 ppm PBZ on mitigating salt stress (200 and 300 mM NaCl) was investigated in soybean (Glycine max L. cv. Planet). We identified that IAA or PBZ and IAA + PBZ improved the physiological parameters that damaged by salinity but PBZ performed best as observed by SEM. However, IAA was more succesfull to induce some antioxidant enzymes (SOD, CAT, APX, POX) although both of them reduced or did not affect GSH- related enzymes (DHAR, MDHAR, GST, GR, GPX). Beside this, combination of IAA and PBZ treatment showed the lowest MDA with inhibited salt stress induced oxidative damage. Additionally, PBZ was more effective against as IAA to reduce the PME and PAL enzyme activities as well as decreased arabinose content, while they were increased with salinity. IAA or PBZ increased lignin content and lead to reduce loosening in roots, while IAA performed best. Overall, this study firstly presents that these regulators ( 50 ppm IAA; 10 ppm PBZ) could be used together to increase salt tolerance in soybean plants via regulating physiological and biochemical metabolism, antioxidant defense system and cell wall modified parameters. Thus, the application of IAA /PBZ to salt treated soybean plants could be utilized as a model to increase plant’s resistance under stress conditions.
ADSC secretome constrains NK cell activity by attenuating IL-2–mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4
Authors: Ko Eunhee , Yoon Taejun , Lee Yoojin , Kim Jongsun , Park Yong-Beom 
Published: May 2023

Abstract
Background: Mesenchymal stem cells (MSCs) have immunomodulatory properties and therapeutic effects on autoimmune diseases through their secreted factors, referred to as the secretome. However, the specific key factors of the MSC secretome and their mechanisms of action in immune cells have not been fully determined. Most in vitro experiments are being performed using immune cells, but experiments using natural killer (NK) cells have been neglected, and a few studies using NK cells have shown discrepancies in results. NK cells are crucial elements of the immune system, and adjustment of their activity is essential for controlling various pathological conditions. The aim of this study was to elucidate the role of the adipose tissue-derived stem cell (ADSC) secretome on NK cell activity.
Methods: To obtain the ADSC secretome, we cultured ADSCs in medium and concentrated the culture medium using tangential flow filtration (TFF) capsules. We assessed cell viability and proliferation using CCK-8 and CFSE assays, respectively. We analyzed the effects of the ADSC secretome on NK cell activity and pathway-related proteins using a combination of flow cytometry, ELISA, cytotoxicity assay, CD107a assay, western blotting, and quantitative real-time PCR. To identify the composition of the ADSC secretome, we performed LC-MS/MS profiling and bioinformatics analysis. To elucidate the molecular mechanisms involved, we used mRNA sequencing to profile the transcriptional expression of human blood NK cells.
Results: The ADSC secretome was found to restrict IL-2–mediated effector functions of NK cells while maintaining proliferative potency. This effect was achieved through the upregulation of the inhibitory receptor CD96, as well as downregulation of activating receptors and IL-2 receptor subunits IL-2Raand IL-2Rg. These changes were associated with attenuated JAK-STAT and AKT pathways in NK cells, which were achieved through the upregulation of cytokine-inducible SH2-containing protein (CIS, encoded by Cish) and dual specificity protein phosphatase 4 (DUSP4). Furthermore, proteomic analysis revealed twelve novel candidates associated with the immunomodulatory effects of MSCs.
Conclusions: Our findings reveal a detailed cellular outcome and regulatory mechanism of NK cell activity by the ADSC secretome and suggest a therapeutic tool for treating NK-mediated inflammatory and autoimmune diseases using the MSC secretome.