bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Evaluation of Musculoskeletal Disorders and Design of Lifting-carrying Facilities
Authors: Agustina Fitri , Ansori Nachnul , Novianti Trisita , Widiaswanti Ernaning , Anggraeni Ravida Ayu 
Published: March 2023

There are main activities of the worker in UD Askan such as splitting the fish, carrying, and lifting the tubs. Work activities are done manually and the production process continually undergoes. The frequency of activity (15 cycles) in a day causes the risk of fatigue, injury, and Musculoskeletal Disorders (MSDs). Evaluation of the work posture of four workers by Ovako Working Posture Analysis System (OWAS) and Job Strain Index (JSI) methods showed high risk in the process of lifting and carrying a tank. The previous posture caused the worker to bend forward, both legs standing or squatting with both knees, and walk by carrying a tub. The results recommend solving soonest due to the danger to the musculoskeletal. The recommendation shows that lifting methods are required and the design of lifting and transporting equipment is needed. The evaluation posture by OWAS show that the process of carrying a tank is 3 level (immediate repair because it is harmful to the musculoskeletal), and after improvement, it is 1 level (not harmful to the musculoskeletal). Then, JSI indicates any improvement from the 3 levels (posing a hazard) to level 1 (safe work).
Influence of site-specific probabilistic seismic hazard on the risk assessment of a masonry tower
Authors: SAYGILI ÖZDEN 
Published: March 2023

Abstract
A probabilistic seismic hazard analysis was performed for İstanbul considering the seismotectonic structure of the region. Earthquakes that occur in seismic regions has the possibility of triggering each other to a certain extent, and this causes earthquakes to cluster in time and space. In this study, the Poisson model was preferred for probabilistic seismic hazard analysis. Conventional integration approach was adopted to calculate the hazard curves to describe the likelihood of exceeding ground motion in a particular period. This paper presents results on the impact of seismic hazard on structural performance of an existing masonry tower, by evaluating the seismic response for different levels of ground motions.
EVAC+: Multi-scale V-net with Deep Feature CRF Layers for Brain Extraction
Authors: Park Jong Sung , Fadnavis Shreyas , Garyfallidis Eleftherios 
Published: March 2023

Abstract
Brain extraction is an indispensable computational necessity for all researchers using brain imaging data. However, the complex structure of the interfaces between the brain, meninges and human skull have not allowed a highly robust solution to emerge. While previous methods have used machine learning with structural and geometric priors in mind, with the development of Deep Learning (DL), there has been an increase in proposed Neural Network architectures to solve such problems. Most DL approaches focus on improving the training data with little change in the DL architecture. However, the amount and quality of accessible training data with expert-labeled ground truth varies between groups. Thus, the performance of many methods heavily depends on the amount and quality of training data. In this paper, we propose a novel architecture we call EVAC+. EVAC+ has 3 characteristics to work around this major issue: (1) a smart augmentation strategy that improves training efficiency, (2) a unique way of using a Conditional Random Fields Recurrent Layer that improves accuracy and (3) a new loss function that fine-tunes the segmentation output. We compare our model to state-of-the-art non-DL and DL methods. Results show that even with limited training resources, EVAC+ outperforms in most cases, achieving a high and stable Dice Coefficient and Jaccard Index along with a desirable lower Surface (Hausdorff) Distance. More importantly, our approach accurately segmented clinical and pediatric data, despite the fact that the training dataset only contains healthy adults. Ultimately, our model provides a reliable way of accurately reducing segmentation errors in complex multi-tissue interfacing areas of the brain. We expect our method, which is publicly available and open-source, to be beneficial to a wide range of researchers.
Adult body constitution and hearing loss: a bidirectional Mendelian randomisation study
Authors: He Yiyan , Karhunen Ville , Pulakka Anna , Kantomaa Marko , Sebert Sylvain 
Published: March 2023

Abstract
Hearing-loss and -disorders represent possible mediating pathways in the associations between noise exposures and non-auditory health outcomes. In this context, we questioned whether the noise-obesity associations should consider hearing functions as possible mediators and applied Mendelian randomisation (MR) to investigate causal relationships between body constitution and hearing impairments.
We obtained genetic associations from publicly available summary statistics from genome-wide association studies in European adult populations (N= from 210,088 to 360,564) for (i) body constitution: body mass index (BMI), waist circumference (WC) and body fat percentage (BFP), and (ii) hearing loss: sensorineural hearing loss, noise-induced hearing loss, and age-related hearing impairment (ARHI). We employed colocalisation analysis to investigate the genetic associations for BMI and ARHI liability within an FTO locus. We conducted bi-directional MR for the ‘forward’ (from body constitution to hearing) and ‘reverse’ directions. We applied the random-effects inverse variance-weighted method as the main MR method, with additional sensitivity analyses.
Colocalisation analysis suggested that BMI and ARHI shared a causal variant at the FTOgene. We did not find robust evidence for causal associations from body constitution to hearing loss and suggested that some associations may be driven by FTO variants. In the reverse analyses, ARHI was negatively associated with BMI [effect size -0.22 (95% CI -0.44 to -0.01)] and BFP [effect size -0.23 (95% CI -0.45 to 0.00)], supporting the notion that ARHI may diminish body constitution. Finally, our data suggest that hearing may have little to no effect on explaining the association between noise exposure and body constitution.
Interaction Effect of Midday Napping Duration and Depressive Symptoms on Subjective Memory Impairment Among Elderly People in China: Evidence from the China Health and Retirement Longitudinal Study Database
Authors: Tang Li , Wang Ya-qi , Zhan Na-ni , Li Can-Yang , Zhuang Zhuang , Lyu Qi-yuan , Xiong Peng 
Published: March 2023

Abstract
Background

Subjective memory impairment (SMI) is common in the elderly. We aimed to reveal the interaction effect of midday napping duration and depressive symptoms on the risk of SMI.

Methods

Using a dataset representative of the Chinese population from a longitudinal study of health and retirement in China, subjects with SMI were screened using the question “how do you feel about your memory now?” and the Mini-Mental State Examination. A logistic regression model was applied to explore the factors affecting SMI. Additive and multiplicative models were used to analyze the interaction effect of midday napping duration and depressive symptoms on the risk of SMI.

Results

We enrolled 8,254 subjects included and the incidence of SMI was 63.9%. Depressive symptoms, nap time, and physical activity were influencing factors of SMI. Midday napping duration and depressive symptoms had positive additive interaction effects on the risk of SMI. When extended-length naps and depressive symptoms coexisted, the risk of SMI was 1.06 times greater than that for either alone (RERI = 0.27, 95% CI = 0.07–0.43; AP = 0.14, 95% CI = 0.01–0.23; S = 1.06, 95% CI = 0.57–1.62). When short naps and depressive symptoms coexisted, the risk of SMI was 1.2 times higher than that for either alone (RERI = 0.12, 95% CI=-0.14–0.39; AP = 0.13, 95% CI=-0.07–0.22; S = 1.20, 95% CI = 0.79–1.82).

Limitations

Since this was a cross-sectional study, the cause-and-effect relationships between the associated variables cannot be inferred.

Conclusions

The interaction effect that exists between nap time and depressive symptoms in the elderly is important for the identification and early intervention of people at risk for SMI.
Cataract surgery with new monofocal intraocular lens enhanced for intermediate vision and standard monofocal intraocular lens for retinal disorder
Authors: Hwang Hye Seong , Lee Hwanho , Park Jin Hyoung , Chae Ju Byung , Kim Dong Yoon 
Published: March 2023

Abstract
AIM

To investigate the difference in the initial surgical results between a new monofocal intraocular lens (IOL) with enhanced intermediate vision and the standard monofocal IOL in patients with retinal disease.

METHODS

We retrospectively reviewed the medical records of patients with retinal disease who underwent cataract surgery due to accompanying cataracts. Preoperative best corrected distant visual acuity, spherical equivalent(SE), and types of retinal diseases were investigated. The surgical results were investigated using uncorrected visual acuity(UCVA) and SE at 1 day, 1 week, and 1 month after surgery.

RESUTLS

Seventeen eyes treated with a new monofocal IOL enhanced for intermediate vision (ICB00 group) and 18 eyes treated with the standard monofocal IOL (AAB00 group) were included in this study. There were no significant differences in the baseline characteristics, including the type of underlying retinal disease, between the groups. There were no significant differences between the groups in terms of distant, intermediate, or near UCVA at day 1 and week 1 after surgery. However, at 1 month after surgery, the ICB00 group showed a significantly better intermediate vision improvement than the AAB00 group (p = 0.001).

CONCLUSION

Even in patients with cataract accompanied by retinal disease, the use of the ICB00 IOL showed significant improvement in intermediate vision compared to the use of the AAB00 (standard monofocal) IOL. The ICB00 IOL might be a good option for patients with cataract and retinal disease in the era of increased intermediate vision needs in daily life.
Functional Outcomes of Young Adults Undergoing Total Knee Replacement – a Systematic Review of the Literature and Meta- Analysis
Authors: Restrepo Ana María Diaz , Morales Jorge Rolando Ortiz , Gutiérrez Giancarlo Buitrago , López Jhon Fredy Castañeda 
Published: March 2023

Abstract
Introduction.
With the increase in primary arthroplasties in young patients, various studies have emerged about revision rates, arthrofibrosis and others, but there is nothing about functional results, which is why the research question arises: How are the functional results and the return to work activities of young adult patients (19–65 yo) who undergo primary knee arthroplasty?
Methods & materials.
A systematic review of the literature was performed using the key words defined by the research group. Data was recorded concerning the type of study and the outcome measurements, complications and real results.
Results.
72 articles included. The results show that there is significant variability in the outcomes in the literature on TKA regarding functionality and few reports of return to work activity. There is evidence in favor of intervening young patients, however, new studies should be carried out with standardization of the results.
Conclusions.
This is a study with an Evidence Level of I; its clinical importance lies in the fact that there are currently no studies focused on determining the functional results and the reinstatement into work for Young adult who undergo primary TKA, and this study offers promising results.
Diabetic Retinopathy Classification Using a Multi-Attention Residual Architecture
Authors: Jin Li , Wang Zijian , Su Yifei , Fang Zhaohui , Lu Haimei , Kan Hongxing 
Published: March 2023

Abstract
Diabetic Retinopathy (DR) is a complication caused by diabetes that can destroy the retina, leading to blurred vision and even blindness. We proposed a deep neural network to classify DR at different stages. The design philosophy of the network is based on classical residual networks. We used a multi-attention mechanism to improve the model's attention for lesion detection. Our proposed network uses a novel down-sampling method that enhances the receptive field size of the model. We introduced Squeeze-to-Excitation blocks to increase the complexity of the model and thus theoretically increase the representational power of the model. The experimental results show that the performance of our model is about 1%-2% higher than other models on the EyePACS test set. The method helps enhance the discrimination ability of the model for non-healthy retinal images and has specific clinical application value.
Prediction of Rock Burst Intensity Based on Multi-Source Evidence Weight and Error-Eliminating Theory
Authors: Wu Shuliang , Yan Qisheng , Tian Sen , Huang Wengang 
Published: March 2023

Abstract
Rock burst is the main geological hazard in deep underground engineering. For the prediction of the intensity of rock burst, a model for prediction of rock burst intensity on the basis of multi-source evidence weight and error-eliminating theory was established. Four indexes including the ratio of rock′s compressive-tensile strength σc/σt , the stress coefficient of rock σθ/σc, the elastic energy index of rock Wet and integrality coefficient Kv were chosen as the prediction variables of rock burst, the index weights are calculated by different weighting methods, and fused with evidence theory to determine the final weight of each index. According to the theory of error-eliminating, taking no rock burst as the objective and using the error function to processed 18 sets of typical rock burst data at home and abroad, and the weight of evidence fusion as the normalized index limit loss value, and a model for prediction of rock burst intensity was build. It is verified by the actual situation and three other models. Finally, the model has been applied to rock burst prediction of Zhongnanshan tunnel ventilation shaft. The results show that evidence theory fuses multi-source index weights and improves the method of determining index weights. The index value is processed by Error-eliminating theory, and the limit value problem of index value normalization is optimized. The predicted results of the proposed model are consistent with the situation of Zhongnanshan tunnel. It improves the objectivity of the rock burst prediction process and provides a research idea for rock burst intensity prediction index.
Enteric parasites in free-living Mediterranean pond turtle (Mauremys leprosa leprosa) in contrasted areas (naturel vs polluted) from central-western of Morocco
Authors: Laghzaoui El-Mustapha , Amahmid Omar , Mouden El Hassan El 
Published: March 2023

Abstract
The objective of this study is to assess the occurrence of intestinal parasites in Mediterranean pond turtle Mauremys leprosa leprosa collected from three contrasting environments in Morocco. Stool samples from 92 turtles were examined for parasite detection and enumeration. The identified intestinal parasites belong to helminths (Oxyurids and Ascarid) and protozoa (Entamoebidae). 27.17% of turtles were found to be infected by helminths and/or protozoan parasites. No adult form of these parasites has been detected. Oxyurid and ascarid eggs were found in individuals of populations studied from Oued Ksob (23.07% - 30.76%) and Oued Zat (34.14% - 24.39%), respectively. For protozoa, Entamoeba cysts were common in turtles in Oued Ksob (15.38%), Oued Zat (12.19%) and Oued Tensift (5.26%) localities. Oxyurid eggs showed the highest intensity at Oued Zat reaching 29.30 ± 59.59 EPG, versus 12 ± 0.38 EPG for Ascaris eggs in Oued Ksob. Entamoeba cysts were detected in lower levels with a maximum of 1.66 ± 1.50 CPG, in Oued Zat. The prevalence of turtles eliminating eggs was statistically significant between localities for different parasite groups. This study reports for the first time a parasitological characterization of gastro-intestinal parasites in wild populations of M. leprosa leprosa from contrasting environments, suggesting a relationship between turtles’ infestation and the quality of their living environment.
Novel intrathoracic irrigation using ultrafine ozone bubbles in a rat empyema model
Authors: IKEDA Masaki , Yutaka Yojiro , Chen-Yoshikawa Toyofumi , Tanaka Michio , Yamamoto Masaki , Tanaka Satona , Yamada Yoshito , Ohsumi Akihiro , Nakajima Daisuke , Hamaji Masatsugu , Yoshizawa Akihiko , Kusaka Eishi , Nagao Miki , Date Hiroshi 
Published: March 2023

Abstract
Dissolved ozone is generally used for sanitization, but it has not been used for thoracic cavity sanitization because of its short half-life (< 20 min) and possible toxicity. We developed a novel solution containing ultrafine ozone bubbles (ozone-UFB) with a 5-fold longer half-life than non-UFB ozone. Using an in vitro model, Staphylococcus aureus colonies were counted after exposure to ozone-UFB or non-UFB ozone at the same ozone concentration (0.4 mg/L). The colony count was significantly lower in the ozone-UFB group than in the non-UFB ozone group (p = 0.034). The effect of repeated pleural irrigation using ozone-UFB and saline was compared in a rat empyema model of S. aureus infection. The bacterial count in the pleural effusion was decreased by at least 5-fold following intrathoracic lavage with ozone-UFB (3 mg/L). To examine the safety of ozone-UFB for intrathoracic use, ozone-UFB with a higher ozone concentration (10 mg/L) was injected into the thoracic cavities of normal rats. The treatment did not result in any specific pleural damage or elevated serum interleukin-6 concentrations. The findings highlighted the efficacy and safety of ozone-UFB for intrathoracic sanitization, but further studies are needed to determine the optimal therapeutic ozone concentration with appropriate safety margins.
Infantile Fibrosarcoma of the Perineum with Dorsal Metastasis in a Neonate: A Case Report Original
Authors: Geng Juan , Chen Dan , Wang Limin , Liu Xiangjiao , Chen Wenjing , Gao Hongyi , Xiao Shangjie 
Published: March 2023

Abstract
Background
Infantile fibrosarcoma is a rare pediatric soft tissue tumor and usually appears in children before one year of age. Distal extremities constitute the most frequently affected locations, and other tissues such as the trunk, head and neck, gut, sacrococcygeal region, and viscera are uncommon sites.
Case presentation
We describe a rare case of infantile fibrosarcoma arising from the perineum. First, a cystic mass was detected using prenatal ultrasonography, and then an echo was changed in serial ultrasound examinations. A solid cystic lesion was found at term; a hypoechoic lesion occurred in the back. The tumor became so large that massive bleeding occurred, which then underwent surgical resection. Pathological examination confirmed infantile fibrosarcoma.
Conclusion
Our report demonstrates not all ultrasonographic findings in cases of infantile fibrosarcoma exhibit a solid mass during the initial examination — an early-stage lesion may reveal a cystic echo. Infantile fibrosarcoma has a good prognosis and surgery constitute the main treatment, with adjuvant chemotherapy being received if necessary.
An Integrated Control Framework for Torque Vectoring and Active Suspension System
Authors: Feng Jiwei , Liang Jinhao , Lu Yanbo , Zhuang Weichao , Pi Dawei , YIN Guodong , Xu Liwei , Peng Pai , Zhou Chaobin 
Published: March 2023

Abstract
Four-wheel independently driven electric vehicles (FWID-EV) endow a flexible and scalable control framework to improve the vehicle performance. This paper integrates the torque vectoring and active suspension system (ASS) for the straight-ahead driving condition, which aims to enhance the vehicle longitudinal and vertical motions control. The nonlinear characteristic of the tire model leads to a heavier computational burden during the optimization. To facilitate the controller design and ease the load, a half-vehicle dynamics system is built and simplified by a linear-time-varying (LTV) model. Then a model predictive controller is developed and its objective function is formulated by comprehensively considering the safety, energy-saving and comfort. The in-wheel motor efficiency and the power loss of tire slip are treated as optimization indices in this work to reduce the energy consumption. Finally, the effectiveness of the proposed controller is verified through the rapid- control-prototype (RCP) test. The results demonstrate the enhancement of the energy-saving as well as comfort on the basis of the vehicle stability.
Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs
Authors: Rangel Marcelo Monte Mor , Linhares Laís Calazans Menescal , Oliveira Krishna Duro , Suzuki Daniela Ota Hisayasu , Maglietti Felipe Horacio , De Nardi Andrigo Barboza 
Published: March 2023

Abstract

Local treatment of canine urothelial carcinoma (UC) of the bladder is a challenge. More than 90% of cases arise as muscle-invasive tumors, with more than 50% developing on bladder sites with a difficult surgical approach often requiring radical procedures. This study aimed to evaluate the safety and feasibility of electrochemotherapy (ECT) with intravenous bleomycin (BLM) as selective local therapy for bladder UC. This prospective study included 21 dogs with spontaneous bladder UC. Neoplastic infiltration in the serosa layer was considered the main exclusion criterion. No patient died during ECT or in the immediate postoperative period, and no patient presented with suture dehiscence. Most dogs (19/21) developed mild adverse effects, whereas two dogs developed ureteral stenosis. Complete response (CR) was achieved in 62% of the dogs (13/21), while partial response (PR) was achieved in 24% (5/21). The mean survival and disease-free survival times were 420 and 405 days, respectively. Overall survival was significantly better in the patients who achieved CR. ECT was well-tolerated in dogs with UC, demonstrating its safety and feasibility. These data pave the way for new studies aimed at evaluating the effectiveness of ECT in canine bladder UC as a translational model for human disease.
Gain-of-function p53 R175H blocks apoptosis in a precursor model of ovarian high-grade serous carcinoma
Authors: Haagsma Jacob , Kolendowski Bart , Buensuceso Adrian , Valdes Yudith R. , DiMattia Gabriel E. , Shepherd Trevor G. 
Published: March 2023

Abstract
Ovarian high-grade serous carcinoma (HGSC) is a highly lethal malignancy for which early detection is a challenge and treatment of late-stage disease is ineffective. HGSC initiation involves exfoliation of fallopian tube epithelial (FTE) cells which form multicellular clusters called spheroids that colonize and invade the ovary. HGSC contains universal mutation of the tumour suppressor gene TP53. However, not all TP53 mutations are the same, as specific p53 missense mutants contain gain-of-function (GOF) properties that drive tumour formation. Additionally, the role of GOF p53 in spheroid-mediated spread is poorly understood. In this study, we developed and characterized an in vitro model of HGSC based on mutation of TP53 in mouse oviductal epithelial cells (OVE). By culturing OVE cells as spheroids, we discovered increased spheroid survival and transformation properties in spheroids expressing the missense mutant p53R175H compared to parental spheroids and spheroids with Trp53 deletion. Transcriptomic analysis on spheroids identified decreased apoptosis signaling due to p53R175H. Further assessment of the apoptosis pathway demonstrated decreased expression of intrinsic and extrinsic apoptosis signaling molecules due to Trp53 deletion and p53R175H, but Caspase-3 activation was only decreased in spheroids with p53R175H. These results highlight this model as a useful tool for discovering early HGSC transformation mechanisms and uncover a potential anti-apoptosis GOF mechanism of p53R175H.