bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between body roundness index and myopia among US adolescents: a cross-sectional study of NHANES 2001-2006
Authors: Wang Dongfang , Sha Fang , Feng JiaoJiao , Su Weihua , Tang Guodong , Song Jike , Bi Hongsheng 
Published: January 2025

AbstractBackgroundThis study analyzed the association between body roundness index (BRI) and myopia in adolescents in the United States.MethodsThis cross-sectional study analyzed the data of a nationally representative survey, the National Health and Nutrition Examination Survey (NHANES) conducted from 2001 to 2006. Among the 7078 adolescents aged 12 to 19 years, 3915 participants were selected for review. BRI, a new obesity assessment index that evaluates visceral fat, was classified into four groups: Q1,< 2.083; Q2, 2.083 to 2.724; Q3, 2.725 to 4.004; Q4, ≥ 4.005. Myopia was defined as SE≤-0.50 diopters (D). Weighted multivariate logistic regression analysis and smooth curve fitting were performed to evaluate the association between BRI and myopia. Additionally, subgroup and sensitivity analysis was applied.ResultsThe prevalence of myopia was 39.4%. Adolescents who are older, have a larger waist circumference, a lower level of vitamin D, a relatively low PIR level, and a higher waist-height ratio (WHtR) are more likely to have a higher BRI. We found a positive association between BRI and myopia before and after adjusting for confounders (odds ratio [OR] = 1.057, 95% confidence interval [CI]: 1.016-1.100,P< 0.01; OR = 1.049, 95%CI: 1.009-1.090,P=0.022). Specifically, after full adjustment for age, sex, race/ethnicity, PIR, guardians’ education, Vitamin D, physical activity, screen time, adolescents in Q4 were 26.1% more likely to develop myopia compared to adolescents in Q1 (OR=1.261, 95% CI:1.046-1.521,P=0.022). There was a general linear trend between BRI and myopia (allPvalues for trend <0.001) and nonlinear association (allPfor nonlinear < 0.05). Subgroup analysis conducted after full adjustment demonstrated positive associations between BRI and myopia in Mexican American adolescents (OR=1.11, 95% CI: 1.05-1.19,P=0.001), women (OR=1.10, 95% CI: 1.05-1.15,P<0.001), those guardians with educational levels lower than high school (OR=1.09, 95% CI: 1.03-1.14,P=0.004), those with PIR < 1.30 (OR=1.07, 95% CI:1.01-1.14,P=0.037) and those with high physical activity (OR=1.08, 95% CI: 1.04-1.13,P<0.001). Sensitivity analysis was applied using weighted ordinal logistic regressions to explore the relationship of BRI with degrees of myopia. The results remained stable after adjusting for potential confounding factors, consistent with the results of BRI and myopia.ConclusionsThis study assessed that in adolescents, an increase in BRI was associated with an increased risk of myopia, especially in women. Additionally, there was a nonlinear association between BRI and myopia. This study aimed to increase public awareness of BRI values, a novel measure of obesity, and that maintaining a moderate BRI can help reduce the risk of myopia.
Development and Validation of a Nomogram for Predicting False Negative IGRA Results in Pulmonary Tuberculosis Patients Using Propensity Score Matching
Authors: Zhang Feng , Gao Yong , Li Tuantuan , Zhang Wei 
Published: January 2025

Objective Exploration of Factors Influencing False-Negative Results in Interferon-Gamma Release Assay (IGRA) for Patients with Pulmonary Tuberculosis (PTB), and Development of a Nomogram Model to Predict IGRA False Negatives, to Optimize Clinical Diagnosis and Treatment Decisions. Methods A total of 143 patients diagnosed with Pulmonary Tuberculosis (PTB) were selected for this study. Among them, 63 patients who were IGRA negative but positive for pathogen detection formed the observation group, while 80 patients who were both IGRA positive and pathogen positive constituted the control group. After balancing potential confounding factors between the two groups using Propensity Score Matching (PSM), clinical characteristics and laboratory indicators of the two groups were compared. Logistic regression analysis was then employed to identify independent risk factors affecting IGRA results. Based on significantly associated factors, a nomogram model was constructed, and its predictive performance was evaluated. Results After propensity score matching, each group consisted of 55 patients. Compared to the control group, the observation group showed significant differences in white blood cell count (WBC), neutrophil count (NEUT), lymphocyte count (LYM), red blood cell count (RBC), hemoglobin (HGB), and albumin (ALB) levels (P < 0.05). Logistic regression analysis revealed that RBC and ALB were influencing factors for false-negative IGRA results. The constructed nomogram model demonstrated a good fit (χ²=6.444, P=0.598), with an area under the receiver operating characteristic curve (AUC) of 0.703 (95% CI: 0.605-0.800), accuracy of 0.682 (95% CI: 0.586-0.767), sensitivity of 0.691 (95% CI: 0.569-0.813), specificity of 0.673 (95% CI: 0.549-0.797), positive predictive value (PPV) of 0.679 (95% CI: 0.556-0.801), and negative predictive value (NPV) of 0.685 (95% CI: 0.561-0.809). Decision curve analysis indicated that the net benefit of predicting false-negative IGRA results using this nomogram model was greater than 0 when the threshold probability ranged from 0.15 to 0.75. Conclusion Lower levels of RBC and ALB may be significant factors contributing to false-negative IGRA results in PTB patients. The constructed nomogram model, incorporating these factors, holds considerable clinical application value for predicting IGRA false negatives, aiding in the improvement of early diagnosis and management strategies for PTB.
Psychometric validation of an Arabic version of the WHO-5 wellbeing scale among Lebanese Adolescents
Authors: Doumit Rita , Hallit Souheil , Sanchez-Ruiz Maria-Jose , El Khoury-Malhame Myriam 
Published: January 2025

ABSTRACTIntroductionWellbeing in adolescence is frequently associated with positive developmental outcomes. The WHO-5 is widely recognized for its brevity, clarity, robust reliability, and cultural validity. In this study, we aimed to assess the psychometric properties of an Arabic version of the WHO-5 scale among Lebanese adolescents.MethodsThis cross-sectional study involved 681 Lebanese school students aged 15-18 years. Participants were assessed using WHO-5 (wellbeing), PHQ-9 (depression), and GAD-7 (anxiety) Arabic questionnaires at two-time points, 3 months apart.ResultsWe found that the 5 items of the WHO-5 converged into a single factor. Composite reliability of scores was adequate in the total sample (ω = .83 / α = .83). The convergent validity for this model was satisfactory. We were able to show the invariance across gender at the configural, metric, and scalar levels, with males showing a higher level of wellbeing compared to females. The pre-posttest assessment for the WHO-5 scale was conducted on 358 participants; the intraclass correlation coefficient was adequate = 0.78 [95% CI .73; .82]. Our analyses also show that wellbeing was negatively correlated with depression (r = −.54; p < .001) and anxiety (r = −.52; p < .001).ConclusionThe Arabic WHO-5 among Lebanese adolescents displayed highly satisfactory psychometric properties, which are evidence of its validity. It could be used to better track positive mental health in this vulnerable age group and could highlight efficiency in interventions aiming to promote wellbeing in adolescents. It could also potentially identify at risk individuals.
Understanding the Relational Aspects of Networks of Care for Maternal and Newborn Health: A Revised Operational Framework
Authors: Fasawe Olufunke , Jenny Alisa , Churchill Robyn , Kalaris Katherine , Bertozzi Stefanp , Prata Ndola , Carmone Andy , Mulwa Dennis Matheka , Vergara Marite , Moran Allisyn , Walker Dilys 
Published: January 2025

Objective: We investigated the relational aspects of the “Networks of Care” (NOC) approach to better define their role and highlight their importance. These relational aspects distinguish NOC from other health system strengthening approaches that aim to enhance the quality of MNH care. NOCs include functional and relational aspects, as defined in the WHO NOC for MNH framework, and offer a promising strategy for enhancing maternal and newborn health (MNH) by strengthening care coordination at an operational level. Methods: We conducted a cross-disciplinary (healthcare, business, military, aviation, education) scoping review of 90 papers and consulted with key stakeholders to identify and synthesize insights about relational aspects and the associated barriers and facilitators for implementation. We then used the literature review findings and stakeholder feedback to define the relational aspects and revise the Networks of Care Operational framework. Results: The revised framework highlights teamwork with its attributes—trust, mutual respect, shared goals, shared values, and psychological safety and behaviors - leadership, shared decision making, situation monitoring and communication. Organizational enablers underlie a NOC to mitigate barriers and strengthen facilitators to teamwork, which include conflict management, complexity of targets, systemic challenges, social ties, formalization of NOC, and roles like boundary spanners. The study identified relational coordination theory as the basis for refining the NOC operational framework. Conclusion: The resulting framework centers relational coordination including teamwork supported by organizational enablers, in enhancing care coordination between health workers, system administrators, and other users and non-health actors in the network. By targeting relational elements in intervention design and evaluation, the revised Operational NOC Framework for MNH may be valuable in strengthening NOC effectiveness and driving quality improvements leading to improved MNH outcomes, and resilient health systems.
The Role of Self-efficacy Towards Health-promoting Lifestyle among Patients with Non-communicable Disease: A Systematic Literature Review
Authors: Shamsuddin Sharifah Maziah Syed , Ahmad Norfazilah , Sutan Rosnah , Ibrahim Roszita 
Published: January 2025

AbstractBackgroundNon-communicable diseases (NCDs) will be a major cause of death worldwide by 2023. One effective strategy for preventing and managing NCDs is the implementation of health-promoting lifestyle intervention programs. Self-efficacy is a key factor associated with the adoption of health- promoting lifestyle practices. This review aims to examine the role of self-efficacy in fostering health-promoting lifestyles among patients with NCDs.MethodA literature search was conducted across three scientific databases — Scopus, PubMed, and Web of Science —targeting original articles published in English between 2015 and 2024 that identified health-promoting lifestyle as an outcome. The quality of the eligible articles was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Tools, and the findings were synthesized through content analysis.ResultsThe initial search identified 308 citations. A total of eight studies meeting the criteria of the JBI Critical Appraisal Tools were included, highlighting the direct effects of self-efficacy. Self- efficacy was demonstrated as a positive predictor of health-promoting lifestyle as a whole construct, as well as the physical activity dimension, among patients with NCDs, particularly those with hypertension, diabetes, cardiovascular disease, chronic obstructive pulmonary disease (COPD), and acute stages of cancer.LimitationAll included studies were cross-sectional design. Therefore, the evidence quality was relatively low and exhibited a high risk of bias. Furthermore, there was language bias as only English- language publications were selected.ConclusionThe findings of this review will guide healthcare providers in enhancing self-efficacy as a crucial positive predictor of health-promoting lifestyles among patients with non-communicable diseases. This approach can be integrated into clinic consultations and intervention programs. Future studies are warranted to evaluate the effectiveness of self-efficacy in improving a health-promoting lifestyle.
Reasons and Challenges of Adopting Flexitarian Diet: A Mixed-Methods Approach Using Natural Language Processing
Authors: Teixeira Carla Djaine , De Lima Djackson Garcia , de Menezes Neto Elias Jacob , Gomes Sávio Marcelino , Jacob Michelle Cristine Medeiros 
Published: January 2025

AbstractIn this study, we analyzed data from a large sample (n = 778) of individuals who identified as flexitarians, using Brazil as a case study. We applied Natural Language Processing (NLP) to characterize the reasons why individuals self-identify as flexitarians. We explored how these self-perceptions contribute to the construction of a flexitarian identity and identified the challenges this group faces in adopting a flexitarian diet. Our results indicate that there is no homogeneous flexitarian identity, but rather a diversity of categories, organized into five distinct clusters: ethical flexitarians (those who express greater concern for the environment and animals), flexible vegetarians (those who often express the desire to become vegetarian but still consume meat), meat lovers (those who enjoy meat but do not feel compelled to consume it), moderate consumers (those who refrain from meat on certain days of the week), and meat reducers (those who actively reduce their meat consumption). The latter three groups are more similar, as they tend to reduce their meat intake due to the belief that meat is not essential in their diet, although they still enjoy its taste. Additionally, we found that the main challenge faced by our participants is directly related to the social environment, specifically the difficulty in finding alternatives to meat, which makes the love for meat’s taste and meat-centric eating habits secondary challenges.
Catalyzing computational biology research at an academic institute through an interest network
Authors: Zak Jaroslav , Newman Ian , Montiel Garcia Daniel J. , Parisi Daniele , Joy Janet , Head Steven R. , Ducom Jean-Christophe , Natarajan Padma , Cui Haissi , Ul-Hasan Sabah 
Published: January 2025

AbstractBiology has been transformed by the rapid development of computing and the concurrent rise of data-rich approaches such as -omics or high-resolution imaging. However, there is a persistent computational skills gap in the biomedical research workforce. Inherent limitations of classroom teaching and institutional core support highlight the need for accessible ways for researchers to explore developments in computational biology. An analysis of the Scripps Research Genomics Core revealed an increasingly diverse set of experiments: the share of experiments other than bulk RNA- or DNA-seq increased from 34% to 60% within 10 years, requiring more tailored computational analyses. These challenges were tackled by forming a volunteer-led affinity group of over 300 academic biomedical researchers interested in computational biology referred to as the Computational Biology and Bioinformatics (CBB) affinity group. This adaptive group has provided continuing education and networking opportunities through seminars, workshops and coding sessions while evolving along with the needs of its members. A survey of CBB’s impact confirmed the group’s events increased the members’ exposure to computational biology educational and research events (79% respondents) and networking opportunities (61% respondents). Thus, volunteer-led affinity groups may be a viable complement to traditional institutional resources for enhancing the application of computing in biomedical research.
T cell plasticity in systemic lupus erythematosus revealed by large-scale T cell receptor repertoire and transcriptome studies
Authors: Nagafuchi Yasuo , Nakano Masahiro , Lagattuta Kaitlyn A. , Ota Mineto , Hatano Hiroaki , Takahashi Haruka , Itamiya Takahiro , Inokuchi Hajime , Raychaudhuri Soumya , Okamura Tomohisa , Fujio Keishi , Ishigaki Kazuyoshi 
Published: January 2025

AbstractCD4+ T cell plasticity plays a pivotal role in immune homeostasis. However, evidence of T cell plasticity and its pathological role in human systemic lupus erythematosus (SLE) is missing due to the lack of a reporter system. Here we utilized T cell receptor (TCR) repertoire data as a molecular signatures alongside transcriptomic dataset. Using a large-scale ImmuNexUT database of autoimmune disease patients including 117 SLE cases, we quantified T cell plasticity across 13 fine-grained T cell-types. We analyzed 6,392 samples in total and identified two orthogonal signatures of repertoire and transcriptome, the cell-type and disease signatures, allowing us to investigate CD4+ T cell plasticity comprehensively. Among all possible patterns, the plasticity level was the highest in effector regulatory T cells (eTreg) to Th1 plasticity, which was replicated in an independent cohort. Moreover, eTreg-to-Th1 plasticity positively correlated with SLE disease activity. Our study provides novel evidence that Treg plasticity is involved in SLE pathology.
Sex and education differences in trajectories of physiological ageing: longitudinal analysis of a prospective English cohort study
Authors: Bloomberg Mikaela , Steptoe Andrew 
Published: January 2025

AbstractBackgroundPhysiological age (PA) derived from clinical indicators including blood-based biomarkers and tests of physiological function can be compared with chronological age to examine disparities in health between older adults of the same age. Though education interacts with sex to lead to inequalities in healthy ageing, their combined influence on longitudinally-measured PA has not been explored. We derived PA based on longitudinally-measured clinical indicators and examined how sex and education interact to inform PA trajectories.MethodsThree waves of clinical indicators (2004/05-2012/13) drawn from the English Longitudinal Study of Ageing (ages 50-100 years) were used to estimate PA, which was internally validated by confirming associations with incident chronic conditions, functional limitations, and memory impairment after adjustment for chronological age and sex. Joint models were used to construct PA trajectories in 8,891 ELSA participants to examine sex and educational disparities in PA.FindingsAmong the least educated participants, there were negligible sex differences in PA until age 60 (sex difference [men-women] age 50=-0.6 years [95% confidence interval=-2.2-0.6]; age 60=0.4 [-0.6-1.4]); at age 70, women were 1.5 years (0.7-2.2) older than men. Among the most educated participants, women were 3.8 years (1.6-6.0) younger than men at age 50, and 2.7 years (0.4-5.0) younger at age 60, with a non-significant sex difference at age 70.InterpretationHigher education provides a larger midlife buffer to physiological ageing for women than men. Policies to promote gender equity in higher education may contribute to improving women’s health across a range of ageing-related outcomes.
RENOVO-NF1 accurately predicts NF1 missense variant pathogenicity
Authors: Bonetti Emanuele , Pellegatta Serena , Rosati Nayma , Eoli Marica , Mazzarella Luca 
Published: January 2025

AbstractThe identification of a pathogenic variant in the NF1 gene is an important step in the diagnosis of the tumor-predisposing and developmental syndrome neurofibromatosis, and is increasingly important in the characterization of sporadic tumors, in which NF1 loss identifies specific biologic subtypes. However, NF1 variant interpretation is complicated by multiple factors including allelic heterogeneity, sequence homology, and the lack of functional assays to confirm loss of function. Computational tools able to predict variant pathogenicity may represent an ideal complement to the lengthy process of clinical validation, often impossible within an adequate time frame.Here, we present RENOVO-NF1, an evolution of our previously published tool RENOVO algorithm, optimized for the interpretation of NF1 variants. RENOVO-NF1 has an accuracy of 98.6% on (likely) pathogenic/(likely) benign (P/LP/B/LB) variants, and importantly shows high accuracy on P/LP/B/LB variants that were initially classified as of unknown significance (VUS), in particular missense. Based on this, we predict reclassification for 79% of the variants currently classified as missense VUS in ClinVar. Since missense VUS are the most represented and problematic variant class, RENOVO-NF1 may significantly aid in diagnostic challenges in neurofibromatosis and in precision oncology for putatively NF1-mutated patients.
Assessing food acquisition, preparation, and consumption practices in South Asia: A systematic review of assessment tools
Authors: Patwardhan Sharvari , Boncyk Morgan , Avula Rasmi , Blake Christine , Akter Fahmida , Das Jai K , Silva Renuka , Menon Purnima , Scott Samuel 
Published: January 2025

ABSTRACTAssessing behaviors related to food choice at individual- and household-levels is essential for improving household diets, but assessment tools are limited. We conducted a systematic review to identify gaps in existing assessment tools for food acquisition, preparation, and household consumption practices in South Asia, wherein diets are rapidly changing, and triple burden of malnutrition is emerging.Systematic search of three academic databases (PubMed, Scopus, and Web of Science Core Collection) using pre-defined keywords were undertaken to identify studies assessing food acquisition, food preparation, and household consumption practices in South Asia, published in English between 2000 and December 2023. Following PRISMA guidelines, two reviewers independently screened titles, abstracts, and full texts based on the inclusion criteria, and extracted data on study characteristics and the assessment tools used to examine the food choice behaviors.Of 11,288 unique articles identified, 46 were included for synthesis. Food acquisition behaviors were assessed by 25 studies, food preparation by eight studies and household consumption practices by 26 studies. Most studies used quantitative methods (n=30), some used qualitative (n=13), and few used mixed methods (n=3), and varied by type of behavior assessed. Likert scales were the most widely used tools of quantitative assessments, while semi-structured interviews were the most common for qualitative assessments. Across the 46 studies, 59 different tools were used to assess food-related behaviors and only 14 studies claimed using validated tools and many studies did not include the full tool in the text or supplement (n=22).Our review highlights the need for expanding food choice behavior assessments to include the less-studied populations such as exploring young children and adolescents’ food choice behaviors and developing a contextually adaptable repository of validated tools to advance our understanding of food choice behaviors in various settings.Registry: Open Science Framework RegistriesRegistration DOI:https://doi.org/10.17605/OSF.IO/5GPEF