bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring crystallite fusion of nanocellulose during colloid condensation
Authors: Doi Yoshinori , Daicho Kazuho , Isobe Noriyuki , Tanaka Reina , Kimura Satoshi , Fujisawa Shuji , Saito Tsuguyuki 
Published: July 2023

AbstractThe crystallinity of cellulose decreases when bundled microfibrils are dispersed in water as cellulose nanofibers (CNFs) or physically separated into finer nanoscale fibrils or single microfibrils. The crystallinity of these CNFs is recovered when they become densely assembled through the dehydration of the dispersion. In this process, multiple CNFs are assumed to partially fuse, leading to the enlargement of crystallite widths. The mechanism of this CNF fusion is, however, not well understood. In this study, the recovery process of the crystallinity of CNFs was monitored by sampling wet CNF gels during condensation from a dilute dispersion to a dense aggregate, followed by wide-angle X-ray diffractometry (WAXD) and solid-state 13C nuclear magnetic resonance (NMR) spectroscopy analyses after supercritical drying. In the WAXD analysis, a two-step enlargement in the (2 0 0) crystal size was observed: the first step was a rapid increase in the range of solid content up to 1%, followed by a gradual increase in the range of 1–85%. The crystallinity index estimated by NMR hardly changed in the range of 0.5–30% but gradually increased in the range of 30–85%. A portion of the CNF samples, without drying, were also subjected to small-angle X-ray scattering and viscoelasticity analyses, indicating that the inter-CNF contact points in water significantly increased until reaching a solid content of 1%, and then at solid contents higher than 1%, the contact areas of each point gradually expanded. Finally, a mechanism of CNF fusion was proposed based on these results.
Finding an Optimal Level of GDNF Overexpression: Insights from Dopamine Cycling
Authors: Marshall Pepin 
Published: July 2023

AbstractThe application of glial cell line-derive neurotrophic factor (GDNF) to cell cultures and animal models has demonstrated positive effects upon dopaminergic neuronal survival and development, function, restoration, and protection. On this basis, recombinant GDNF protein has been trialled in the treatment of late-stage human Parkinson’s disease patients with only limited success that is likely due to a lack of viable receptor targets in an advanced state of neurodegeneration. The latest research points to more refined approaches of modulating GDNF signalling and an optimal quantity and spatial regulation of GDNF can be extrapolated using regulation of dopamine as a proxy measure. The basic research literature on dopaminergic effects of GDNF in animal models is reviewed, concluding that a twofold increase in natively expressing cells increases dopamine turnover and maximises neuroprotective and beneficial motor effects whilst minimising hyperdopaminergia and other side-effects. Methodological considerations for measurement of dopamine levels and neuroanatomical distinctions are made between populations of dopamine neurons and their respective effects upon movement and behaviour that will inform future research into this still-relevant growth factor.
Graphical Abstract
Measuring the cosmic X-ray background accurately
Authors: Li Hancheng , Walter Roland , Produit Nicolas , Hubert Fiona 
Published: July 2023

AbstractSynthesis models of the diffuse Cosmic X-ray Background (CXB) suggest that it can be resolved into discrete sources, primarily Active Galactic Nuclei (AGNs). Measuring the CXB accurately offers a unique probe to study the AGN population in the nearby Universe. Current hard X-ray instruments suffer from the time-dependent background and cross-calibration issues. As a result, their measurements of the CXB normalization have an uncertainty of the order of$$\sim $$∼15%. In this paper, we present the concept and simulated performances of a CXB detector, which could be operated on different platforms. With a 16-Unit CubeSat mission running for more than two years in space, such a detector could measure the CXB normalization with$$\sim $$∼1% uncertainty.
Enabling Indigenous wellbeing in higher education: Indigenous Australian youth-devised strategies and solutions
Authors: Durmush Georgia , Craven Rhonda G. , Yeung Alexander Seeshing , Mooney Janet , Horwood Marcus , Vasconcellos Diego , Franklin Alicia , Duncan Christopher , Gillane Renee 
Published: July 2023

Abstract

Indigenous youth comprise over half of the Indigenous Australian population; however, there is a scarcity of research that focuses on improving Indigenous Australians’ wellbeing in higher education. The purpose of this study was to identify Indigenous-devised strategies to support wellbeing of salience to Indigenous Australian higher education students. Using Indigenous methodology, Indigenous youth (N = 7; aged between 18 and 25 years) studying at three higher education institutions in Australia participated in semi-structured interviews. Thematic analysis identified strategies and solutions for supporting and enhancing Indigenous youth wellbeing in higher education. Participants suggested that their wellbeing would benefit from increased opportunities for them to gain role models. They also suggested culturally supportive higher education environments were critical and could be achieved by employing more Indigenous academics and Indigenous mentors to implement personalised student support, introducing mandatory cultural competency training for all staff, and employing culturally safe counselling services. Indigenous youth also suggested strategies for enhancing institutional policy such as ensuring Indigenous culture and perspectives were taught across all faculties; developing reconciliation action plans, financial support, and scholarships to require proof of Aboriginality and evidence of hardship; and an institutional wellbeing strategy designed to support Indigenous students’ wellbeing.
Coordinated Priming of NKG2D Pathway by IL-15 Enhanced Functional Properties of Cytotoxic CD4+CD28− T Cells Expanded in Systemic Lupus Erythematosus
Authors: Wang Tingting , Wei Laiyou , Meng Shuhui , Song Wencong , Chen Yulan , Li Heng , Zhao Qianqian , Jiang Zhenyou , Liu Dongzhou , Ren Huan , Hong Xiaoping 
Published: July 2023

Abstract
Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder, and numerous aberrations of T cell responses have been reported and were implicated in its pathophysiology. Recently, CD4-positive T cells with cytotoxic potential were shown to be involved in autoimmune disease progression and tissue damage. However, the effector functions of this cell type and their potential molecular mechanisms in SLE patients remain to be elucidated. In this study, we find that cytotoxic CD4+CD28− T cells are expanded in SLE patients with flow cytometry analysis, and the percentage of CD4+CD28− T cells positively correlates with the Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI). Furthermore, our study suggests that interleukin-15 (IL-15) promotes the expansion, proliferation, and cytotoxic function of CD4+CD28− T cells in SLE patients through activation of the Janus kinase3-STAT5 pathway. Further study indicates that IL-15 not only mediates the upregulation of NKG2D, but also cooperates with the NKG2D pathway to regulate the activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway. Together, our study demonstrated that proinflammatory and cytolytic CD4+CD28− T cells expand in SLE patients. The pathogenic potential of these CD4+CD28− T cells is driven by the coupling of the IL-15/IL-15R signaling pathway and the NKG2D/DAP10 signaling pathway, which may open new avenues for therapeutic intervention to prevent SLE progression.
Authorial Power, Authoritarianism, and Exiled Intellectuals: Syria and Turkey
Authors: Al Azmeh Zeina , Dillabough Jo-Anne 
Published: July 2023

AbstractHow does a crisis of the state and its ‘emergency politics’ lead to a crisis of the intellectual, or what does it mean to be an intellectual in our contemporary conjuncture beyond Western clichés and the universalistic bias of their declinist arguments? In responding to these questions, we draw upon data collected from Turkish and Syrian academics living in exile to argue that the critical commitments exiled intellectuals presume are under threat as rising authoritarianisms take hold globally and advanced neo-liberal practices tighten their grip on universities. The promise of Said’s figuration of the ‘intellectual in exile’ and its political potential is also under threat as displaced scholars navigate democratic backsliding and structural precarity in the contemporary university and in the nation-states to which they have found themselves tied, eroding even further the conceptual idea of the critical intellectual and the potential power of the ‘post-colonial intellectual’. In our research, this crisis of the intellectual is recounted by exilics paradoxically in both the autocratic and the ‘nominally democratic’ higher education (HE) context where in some cases the very idea of the intellectual can represent, at least in part, a banal political figuration epitomised in what Nancy Fraser refers to as progressive neo-liberalism. This is largely so because both authoritarian and nominally democratic states, whilst different in political charge, are simultaneously invoking ‘states of emergency’ and culture wars that are eroding their own intellectual constituencies’ ability to disturb existing institutional norms and the taken for granted problems that emerge in everyday HE practices.
The new dynamics of career self-management: a study with remote workers
Authors: Sotto-Mayor José Diogo , Simão Claúdia , Carneiro Pinto Joana 
Published: July 2023

AbstractWe analyse a career self-management model for remote workers by exploring the nature, causes and consequences of strategic career behaviours. Perceived self-efficacy and desire for career control are predictors of strategic career behaviours, and these behaviours determine career satisfaction, but not perceived career control nor objective or subjective career success. Also, perceived organizational support predicts perceived self-efficacy and career satisfaction, and self-efficacy predicts subjective career success which, in turn, is associated with career satisfaction. Workplace renovation is needed to accommodate the new forms of remote working and to develop new career management strategies to reinforce the motivation of remote employees.
Acceptance of online customer channels for damage claims in Germany
Authors: Lang Fabian , Riegel Lukas 
Published: July 2023

Abstract
The digital transformation with its new technologies and customer expectation has a significant effect on the customer channels in the insurance industry. The objective of this study is the identification of enabling and hindering factors for the adoption of online claim notification services that are an important part of the customer experience in insurance. For this purpose, we conducted a quantitative cross-sectional survey based on the exemplary scenario of car insurance in Germany and analyzed the data via structural equation modeling (SEM). The findings show that, besides classical technology acceptance factors such as perceived usefulness and ease of use, digital mindset and status quo behavior play a role: acceptance of digital innovations, lacking endurance as well as lacking frustration tolerance with the status quo lead to a higher intention for use. Moreover, the results are strongly moderated by the severity of the damage event—an insurance-specific factor that is sparsely considered so far. The latter discovery implies that customers prefer a communication channel choice based on the individual circumstances of the claim.
Gaze Following as an Early Diagnostic Marker of Autism in a New Word Learning Task in Toddlers
Authors: Camero Raquel , Gallego Carlos , Martínez Verónica 
Published: July 2023

AbstractThe aim was to test the use of eye-tracking methodology for the early detection of ASD in a task of association between unfamiliar objects and pseudowords. Significant differences were found between ASD (n = 57) and TD (n = 57) Spanish speaking toddlers in the number and time of fixation. The TD children showed more and longer fixations on eyes and mouth while the ASD children attended almost exclusively to objects, making it difficult to integrate lexical and phonological information. Moreover, the TD toddlers looked at the mouth when the pseudoword was produced while the ASD toddlers did not. Gaze fixation on eyes and mouth during word learning recorded by eye-tracking may be used as a biomarker for the early diagnosis of ASD.
Exploring Handgrip Strength as a Cross-cultural Correlate of Body Composition and Upper Body Strength in Older Adults from Costa Rica and Kansas
Authors: Moncada-Jiménez José , Dicker Eva E. , Chacón-Araya Yamileth , Peralta-Brenes Mariana , Briceño-Torres José M. , Villarreal-Ángeles Mario , Salazar-Villanea Mónica , Vidoni Eric D. , Burns Jeffery M. , Johnson David K. 
Published: July 2023

AbstractSarcopenia and disability in older adults are often characterized by body composition measurements; however, the gold standard of body composition measurement, dual-energy X-ray absorptiometry (DEXA), is expensive to acquire and maintain, making its use in low and middle income countries (LMIC) it out-of-reach in developing nations. Because these LMIC will bear a disproportionate amount of chronic disease burden due to global aging trends, it is important that reliable, low-cost surrogates need to be developed. Handgrip strength (HGS) is a reliable measure of disability in older adults but has not been used widely in diverse populations. This study compared HGS to multiple measurements of body composition in older adults from the US (Kansas) and a middle-income country (Costa Rica) to test if HGS is a cross-culturally appropriate predictive measure that yields reliable estimates across developed and developing nations. Percent body fat (%BF), lean tissue mass index (LTMI), appendicular lean soft tissue index (ALSTI), body fat mass index (BFMI), bone mineral density (BMD), and HGS were measured in older Costa Ricans (n = 78) and Kansans (n = 100). HGS predicted lean arm mass with equal accuracy for both samples (p ≤ 0.05 for all groups), indicating that it is a reliable, low-cost and widely available estimate of upper body lean muscle mass. Older adults from Costa Rica showed different body composition overall and HGS than controls from Kansas. Handgrip operates equivalently in the US and Mesoamerica and is a valid estimate of lean arm muscle mass as derived by the more expensive DEXA.
Influence of process parameter variation on the microstructure of thin walls made of Inconel 718 deposited via laser-based directed energy deposition with blown powder
Authors: Mueller M. , Franz K. , Riede M. , López E. , Brueckner F. , Leyens C. 
Published: July 2023

AbstractIn laser-based directed energy deposition (L-DED) of Inconel 718 the microstructure of the fabricated components strongly depends on the applied process parameters and the resulting solidification conditions. Numerous studies have shown that the process parameters deposition speed and laser power have a major influences on microstructural properties, such as dendrite morphology and segregation behavior. This study investigates how changes in these process parameters affect the microstructure and hardness when the line mass, and thus the resulting layer height, are kept constant. This enables the microstructural comparison of geometrically similar specimens that were manufactured with the same number of layers but severely different process parameters. This approach yields the benefit of almost identical geometrical boundary conditions, such as the layer-specific build-height and heat conducting cross section, for all specimens. For microstructural analysis scanning electron microscopy and energy dispersive X-ray spectroscopy were applied and the results evaluated in a quantitative manner. The microstructural features primary dendritic arm spacing, fraction and morphology of precipitated Laves phase as well as the spatially resolved chemical composition were measured along the build-up direction. The occurring cooling rates were calculated based on the primary dendritic arm spacing using semi-empirical models. Three different models used by others researchers were applied and evaluated with respect to their applicability for L-DED. Finally, microhardness measurements were performed for a baseline evaluation of the influence on the materials’ mechanical properties.
Effect of O/N content on the phase, morphology, and optical properties of titanium oxynitride thin films
Authors: Ali Sharafat , Magnusson Roger , Pshyk Oleksandr , Birch Jens , Eklund Per , le Febvrier Arnaud 
Published: July 2023

AbstractPhase formation, morphology, and optical properties of Ti(O,N) thin films with varied oxygen-to- nitrogen ration content were investigated. The films were deposited by magnetron sputtering at 500 °C on Si(100) and c-plane sapphire substrate. A competition between a NaCl B1 structure TiN1−xOx, a rhombohedral structure Ti2(O1−yNy)3, and an anatase structure Ti(O1−zNz)2 phase was observed. While the N-rich films were composed of a NaCl B1 TiN1−xOx phase, an increase of oxygen in the films yields the growth of rhombohedral Ti2(O1-yNy)3 phase and the oxygen-rich films are comprised of a mixture of the rhombohedral Ti2(O1−yNy)3 phase and anatase Ti(O1−zNz)2 phase. The optical properties of the films were correlated to the phase composition and the observation of abrupt changes in terms of refractive index and absorption coefficient. The oxide film became relatively transparent in the visible range while the addition of nitrogen into films increases the absorption. The oxygen rich-samples have bandgap values below 3.75 eV, which is higher than the value for pure TiO2, and lower than the optical bandgap of pure TiN. The optical properties characterizations revealed the possibility of adjusting the band gap and the absorption coefficient depending on the N-content, because of the phases constituting the films combined with anionic substitution.
Construction of lncRNA- and circRNA-associated ceRNA networks in the prostatic urethra of rats after simulating transurethral laser prostatectomy (TULP)
Authors: Tang XiaoHu , Liu ZhiYan , Liu Hao , Zhang Heng , Tian Ye , Xia ShuJie , Sun ZhaoLin , Luo GuangHeng 
Published: July 2023

AbstractNon-coding RNA appears to be involved in wound repair. Competing endogenous RNA (ceRNA) appears to be an important post-transcriptional mechanism, it means that long noncoding RNA (lncRNA) or circular RNA (circRNA) acts as a microRNA (miRNA) sponge to further regulate mRNA. However, ceRNA network related to wound repair after prostatectomy has yet been constructed. TULP is the main surgical method of prostatectomy, but there have been no reports of TULP rat models in the past. We simulated TULP on rats, and observed the whole process of wound injury and repair after operation through pathological examination of wound tissue. Next, we discovered 732 differentially expressed lncRNAs (DElncRNAs), 47 differentially expressed circRNAs (DEcircRNAs), 17 differentially expressed miRNAs (DEmiRNAs), and 1892 differentially expressed mRNAs (DEmRNAs) related to wound repair after TULP through full transcriptome microarray and bioinformatics methods, and confirmed the reliability of transcriptome data by quantitative Reverse Transcription PCR (qRT-PCR), and immunohistochemistry. Then, we constructed the lncRNA- and circRNA-associated ceRNA regulatory networks related to wound repair after TULP in rats. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses showed that molecules in these networks were mainly involved in inflammatory infiltration, cell differentiation, and intercellular interactions and involved signal pathways such as the PI3K-Akt signaling pathway. Thus, this study successfully established the TULP model in rats, revealed potentially important biomarkers and ceRNA networks after prostatectomy in rats, and provided theoretical support for the repair of post-prostatectomy wound.
Incidental language and culture learning through mobile technologies: a multi-case study
Authors: Prandi Catia , Valva Antonella , Salomoni Paola , Roccetti Marco , Mirri Silvia 
Published: July 2023

AbstractIncidental learning is a human learning paradigm that takes its form as a response to unplanned initiatives, potentially occurring at any time and at any place. It is emerging as very promising in the case of learning a second language, as it multiplies the occurrence of unexpected and unintentional learning situations. Still open, and subject of debate, is the issue of which is the right methodology to be applied when mobile computer-based technologies are exploited to provide support to such kind of a learning paradigm. Drawing on the results of an international Project (ILOCALAPP), in this paper we provide our reflections on a specific incidental learning methodology we have adopted, based on the use of a mobile application (the UniOn! App) that was developed at the University of Bologna to support mobility students in their daily activities. Our main goal was to understand if such an approach was effective to let individuals incidentally learn the Italian language and culture driven by our mobile application, while conducting informal and daily activities. Specifically, we aimed to measure how much students have learned Italian, by means of self-evaluation and self-assessment tools and statistical analysis, involving 95 students who incidentally improve their Italian language skills, supported by the app. In particular, we adopted a quasi-experimental design, and we focused our investigation on four different dimensions: target users, users’ language background, duration and frequency of use, context of use. The 95 participants were grouped into 5 case studies, based on the four different dimensions. After having used the app, the participants were asked to answer a survey. The obtained results confirm the viability of our approach, showing that incidental learning is enhanced if certain conditions (i.e., integrated guidance) are met, where more than 55% of the participants reported to be more confident about their acquired skills.