bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonvolatile Displays Based on Phase Change Materials
Authors: Cui Yuying , Zhang Yunyan , Cheng Zhiyuan 
Published: September 2023

AbstractWith an increasing requirement to showcase dynamic and adaptable content for diverse purposes, ranging from interactive marketing to energy efficiency initiatives, it is vital to develop technologies that consume negligible power to display images and exhibit good sunlight legibility, rapid refresh rates, and full‐spectrum color reproduction. Nonvolatile displays based on phase change materials (NvD‐PCMs) can satisfy all the aforementioned criteria and have attracted immense attention in academia and industry. However, despite advancements in the color‐changing performance of such coatings, NvD‐PCM technology remains associated with several challenges, such as the lack of a microstructural‐origin‐based systematic explanation of the color‐generating mechanism and development of pixelated displays. This paper comprehensively reviews recent advances in NvD‐PCMs. It discusses the intrinsic properties and material selection of PCMs for display applications, summarizing the rendering mechanism for adjustable structural colors and challenges associated with nanopixel display technology, finally providing a multidimensional outlook on the future research direction in this domain. By overcoming the constraints of NvD‐PCMs and exploring their potential, this review aims to contribute to their advancement, facilitating the development of innovative display technologies that meet the increasing demands of various industries.
“Co‐Stabilization, Fine‐Tuning” Strategy for Highly Stable Coloring of Stimuli‐Responsive Materials and their Hydrochromic Applications
Authors: Gao Junli , Wang Songcheng , Qin Tianyou , Xi Guan , Zhang Sean Xiao‐An , Sheng Lan 
Published: September 2023

AbstractIt is of great significance, but extremely challenging, to endow stimulus‐response materials with both excellent dynamic responsiveness and high coloring stability. Herein, a strategy of “co‐stabilization, fine‐tuning” is proposed to address this conundrum by manipulating multiple dynamically competing supramolecular interactions and conformational fine‐tuning linked coloring. With this idea, a new supramolecular hydrochromic system is constructed and the as‐prepared dye‐based hydrochromic materials (DHMs) have a highly stable water‐induced coloration in a wide pH range, abnormally high temperature, and high salt concentration. Meanwhile, it possesses the best comprehensive performance of hydrochromism (i.e., high optical contrast, multicolor, excellent repeatability). These new DHMs can not only meet the general needs, but also have some unique applications in helping humans adapt to “harsh environments”. The verified “co‐stabilization, fine‐tuning” strategy promises to bring unlimited ideas and implications for functional materials to cope with abnormal environments.
Modular Droplet‐Based Fluidics for Large Volume Libraries of Individual Multiparametric Codes in Lab‐On‐Chip Systems
Authors: Schütt Julian , Nhalil Hariharan , Fassbender Jürgen , Klein Lior , Grosz Asaf , Makarov Denys 
Published: September 2023

AbstractDroplet‐based lab‐on‐a‐chip systems offer vast possibilities in the manipulation, guidance, tracking, and labeling of individual droplet‐based bioreactors. One of the targeted application scenarios is in drug discovery where millions of unique codes are required, which is out of reach for current technologies. Here, a concept for the realization of multiparametric codes, where information is stored in distinct physical and chemical parameters, is proposed and validated. Exemplarily, the focus is on the use of impedance and magnetic sensing by monitoring ionic concentration as well as magnetic content per droplet and droplet volume. Codes based on aqueous ferrofluid droplets are prepared using a tubing‐based millifluidic setup and consist of up to six droplets of different combinations of volumes and magnetic concentration. It is demonstrated that a droplet chain of three single droplets of different volumes with nine different magnetic nanoparticle concentrations accompanied with four different ionic concentrations per droplet offers up to 3 million unique codes. The developed fluidic platform can be readily extended to other types of sensors including optical ones to boost the coding capacity even further.
Artificial intelligence and satellite‐based remote sensing can be used to predict soybean (Glycine max) yield
Authors: Joshi Deepak R. , Clay Sharon A. , Sharma Prakriti , Rekabdarkolaee Hossein Moradi , Kharel Tulsi , Rizzo Donna M. , Thapa Resham , Clay David E. 
Published: September 2023

AbstractBecause the manual counting of soybean (Glycine max) plants, pods, and seeds/pods is unsuitable for soybean yield predictions, alternative methods are desired. Therefore, the objective was to determine if satellite remote sensing‐based artificial intelligence (AI) models could be used to predict soybean yield. In the study, multiple remote sensing‐based AI models were developed for soybean growth stage ranging from VE/VC (plant emergence) to R6/R7 (full seed to beginning maturity). The ability of the deep neural network (DNN), support vector machine (SVM), random forest (RF), least absolute shrinkage and selection operator (LASSO), and AdaBoost to predict soybean yield, based on blue, green, red, and near‐infrared reflectance data collected by the PlanetScope satellite at six growth stages, was determined. Remote sensing and soybean yield monitor data from three different fields in 2 years (2019 and 2021) were aggregated into 24,282 grid cells that had the dimensions of 10 m by 10 m. A comparison across models showed that the DNN outperformed the other models. Moreover, as crops matured from VE/VC to R4/R5, the R2 value of the models increased from 0.26 to over 0.70. These findings indicate that remote sensing data collected at different growth stages can be combined for soybean yield predictions. Moreover, additional work needs to be conducted to assess the model's ability to predict soybean yield with vegetation indices (VIs) data for fields not used to train the model.
Electrostatic and hydrophobic interaction cooperative nanochaperone regulates protein folding
Authors: Wu Xiaohui , Deng Fei , Chen Yujie , Xu Mengchen , Ma Feihe , Shi Linqi 
Published: September 2023

AbstractNatural molecular chaperones utilize spatially ordered multiple molecular forces to effectively regulate protein folding. However, synthesis of such molecules is a big challenge. The concept of “aggregate science” provides insights to construct chemical entities (aggregates) beyond molecular levels to mimic both the structure and function of natural chaperone. Inspired by this concept, herein we fabricate a novel multi‐interaction (i.e., electrostatic and hydrophobic interaction) cooperative nanochaperone (multi‐co‐nChap) to regulating protein folding. This multi‐co‐nChap is fabricated by rationally introducing electrostatic interactions to the surface (corona) and confined hydrophobic microdomains (shell) of traditional single‐hydrophobic interaction nanochaperone. We demonstrate that the corona electrostatic attraction facilitates the diffusion of clients into the hydrophobic microdomains, while the shell electrostatic interaction balances the capture and release of clients. By finely synergizing corona electrostatic attraction with shell electrostatic repulsion and hydrophobic interaction, the optimized multi‐co‐nChap effectively facilitated de novo folding of nascent polypeptides. Moreover, the synergy between corona electrostatic attraction, shell electrostatic attraction and shell hydrophobic interaction significantly enhanced the capability of multi‐co‐nChap to protect native proteins from denaturation at harsh temperatures. This work provides important insights for understanding and design of nanochaperone, which is a kind of ordered aggregate with chaperone‐like activity that beyond the level of single molecule.
Management of preeclampsia with severe features in a patient with relapsing polychondritis affecting the tracheobronchial tree
Authors: Martín‐Serrano P. , Sarrió‐Badenes E. , Durá‐Aranda M. , Molero‐Sala L. 
Published: September 2023

SummaryRelapsing polychondritis is a rare disease that affects cartilaginous structures throughout the body. Progressive destruction of the laryngeal structures and the tracheobronchial tree occurs in 50% of patients, potentially leading to loss of patency and collapse of the airway. Respiratory involvement in relapsing polychondritis includes airway stenosis, tracheomalacia and recurrent lung infections due to chronic inflammation caused by the destruction of upper and lower airway cartilage. Pregnancy and preeclampsia can worsen pharyngolaryngeal oedema, while treatment with magnesium sulphate can affect neuromuscular function, exacerbating the degree of airway collapse in the most serious cases of relapsing polychondritis, possibly altering obstetric outcomes. Here, we present the management of a pregnant woman with relapsing polychondritis who presented with features of severe preeclampsia at 29 weeks and 6 days gestation. We believe that this is the first published case of the combination of the two disorders, complicated by acute respiratory failure after treatment with magnesium sulphate.
Utilisation of certification schemes for recycled products in the Australian building and construction sector
Authors: Shooshtarian Salman , Maqsood Tayyab , Wong Peter S. P. , Zaman Atiq , Caldera Savindi , Ryley Tim 
Published: September 2023

AbstractRecycled product certification (RPC) schemes may prove useful to ensure the desired quality and gain buyer confidence in purchasing products with recycled content (PwRC). RPCs are relatively new to the sector and have not been widely adopted. Hence, this study aims to investigate the implementation of RPC in construction projects using a multiple‐case study approach. The analysis reveals that a large proportion of respondents were unaware of these schemes. The study finds that while a majority favoured RPC application, there were significant variations in responses among stakeholder groups. Moreover, the study identifies six advantages and seven significant barriers associated with the use of RPC in the sector. This study recommends leveraging education and supportive regulation for the effective implementation of RPC. In particular, the policymakers who intend to embed RPC in procurement policies for purchasing PwRC can learn about the identified loopholes and strategies and address them accordingly.
Families of four‐year‐old children experiencing violence: A national survey of parents and public health nurses on help and support
Authors: Leppäkoski Tuija , Vuorenmaa Maaret , Paavilainen Eija 
Published: September 2023

AbstractIntimate partner violence (IPV) and child maltreatment (CM) – together referred to as family violence (FV) – often co‐occur. In Finland, public health nurses play an important role in identifying FV. They regularly meet families and assess children's health until the child turns seven. This nationwide retrospective cross‐sectional survey (FinChildren) aimed to describe and compare help and support needs in violent families from the perspectives of the parents of four‐year‐old children and public health nurses for advancing families' and professionals' collaboration in preventing FV. The data (N = 7476 families) included the responses of one parent from each family and public health nurses, caring for that certain family. The data analysis encompassed statistical methods. The results showed that 47.0% of the parents reported FV. The public health nurses assessed that 0.7% of the parents would have needed support for CM and 1.3% for IPV. They assessed that the parents involved in FV needed more support for their personal coping (p < 0.001) and intimate relationship (p < 0.017) compared with parents without FV. These parents were also found to have other support needs. We concluded that public health nurses recognise only a fraction of FV occurring in families. Risk assessment tools are needed to enable child and family professionals to better intervene in and prevent FV.
Quantification of Phytochemicals and Metal Ions as well as the Determination of Volatile Compounds, Antioxidant, Antimicrobial and Antacid Activities of the Mimosa pudica L. Leaf: Exploration of Neglected and Under‐Utilized Part
Authors: Gandhi Ms. Yashika , Prasad Shyam Baboo , Kumar Vijay , Soni Hemant , Rawat Hemant , Mishra Sujeet K. , Grewal Jyotika , Singh Simranjeet , Charde Vaibhav , Gupta Akhil , Jha Sudhanshu Kumar , Singh Gagandeep , Tandon Smriti , Mrkute Akshada , Ramamurthy Praveen C. , Narasimhaji Ch. Venkata , Singh Arjun , Singh Ravindra , Srikanth Narayan , Acharya Rabinarayan , Webster Thomas J. 
Published: September 2023

AbstractMimosa pudica L. (MP) is well‐known plant in traditional medicinal system, especially in India. Unfortunately, leaves of MP are less explored. To determine the food and nutritional value of the neglected part of Mimosa pudica L. (MP), that is MP leaves, phytochemicals and metal ions of MP were quantified by newly developed HPLC and ICPOES‐based methods. The content of phytochemicals observed using HPLC analysis for chlorogenic acid, catechin, and epicatechin was 141.823 (±8.171), 666.621 (±11.432), and 293.175 (±12.743) μg/g, respectively. Using GC/MS/MS analysis, fatty acid like oleic acid were identified. In ICP‐OES analysis, a significant content of Na, K, Ca, Cu, Fe, Mg, Mn, and Zn was observed. The observed TPC and TFC for MP leaf extracts was 44.327 (±1.041) mg GAE/ g of wt. and 214.217 (±4.372) mg QCE/ g of wt., respectively. The DPPH assay depicted a strong antioxidant activity of MP leaf extracts with IC50 values of 0.796 (±0.081) mg/mL and a TEAC value of 0.0356 (±0.0003). A significant antacid activity (666 mg MP+400 mg CaCO3 >400 mg CaCO3 ≫666 mg Gelusil) of MP leaves was noticed. The methanolic extract of MP leaves demonstrated anti‐microbial activity against Staphylococcus aureus (15±2mm), Pseudomonas aeruginosa (12±2mm) and Escherichia coli (10±2mm). In silico studies confirmed the in vitro results obtained for antioxidant, antiacid, and anti‐microbial activities. In addition, in silico studies revealed the anti‐cancerous and anti‐inflammatory potential of the MP leaves. In summary, this study demonstrated the medicinal significance of MP leaves and the conversion of agro‐waste or the under‐utilized part of MP into pharmaceutical potent materials. Consequently, the present study highlighted that MP leaves alone have medicinal importance with good nutritional utility and possess large promise in the pharma industry along with improving bio‐valorization and the environment.
Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic Activity Across Species**
Authors: Jung Erik , Kraimps Anastassia , Dittmann Silvia , Griesser Tizian , Costafrolaz Jordan , Mattenberger Yves , Jurt Simon , Viollier Patrick H. , Sander Peter , Sievers Susanne , Gademann Karl 
Published: September 2023

AbstractFidaxomicin (Fdx) is a natural product antibiotic with potent activity against Clostridioides difficile and other Gram‐positive bacteria such as Mycobacterium tuberculosis. Only a few Fdx derivatives have been synthesized and examined for their biological activity in the 50 years since its discovery. Fdx has a well‐studied mechanism of action, namely inhibition of the bacterial RNA polymerase. Yet, the targeted organisms harbor different target protein sequences, which poses a challenge for the rational development of new semisynthetic Fdx derivatives. We introduced substituents on the two phenolic hydroxy groups of Fdx and evaluated the resulting trends in antibiotic activity against M. tuberculosis, C. difficile, and the Gram‐negative model organism Caulobacter crescentus. As suggested by the target protein structures, we identified the preferable derivatisation site for each organism. The derivative ortho‐methyl Fdx also exhibited activity against the Gram‐negative C. crescentus wild type, a first for fidaxomicin antibiotics. These insights will guide the synthesis of next‐generation fidaxomicin antibiotics.
Restoration of von Willebrand factor after transcatheter aortic valve replacement—A possible cause for posttranscatheter aortic valve replacement thrombocytopenia?
Authors: Roth Nastasia , Heidel Carolin , Xu Congde , Hubauer Ute , Wallner Stefan , Meindl Christine , Holzamer Andreas , Hilker Michael , Creutzenberg Marcus , Sossalla Samuel , Maier Lars , Jungbauer Carsten , Debl Kurt 
Published: September 2023

AbstractObjectivesThe aim of the current study was to analyze the clinical and procedural predictors of thrombocytopenia and the relationship between the decrease in platelet count (DPC) and change in vWF function (ΔvWF) after transcatheter aortic valve replacement (TAVR).BackgroundTAVR often causes temporary thrombocytopenia. At the same time, TAVR leads to a restoration of von Willebrand factor (vWF) function.MethodsOne hundred and forty‐one patients with severe aortic stenosis undergoing TAVR were included in the study. Platelet count and vWF function (vWF:Ac/Ag ratio) were assessed at baseline and 6 h after TAVR. Thrombocytopenia was defined as platelet count <150/nL.ResultsMedian platelet count at baseline was 214/nL (interquartile range [IQR]: 176–261) and decreased significantly to 184/nL (IQR: 145–222) 6 h after TAVR. The number of patients with thrombocytopenia increased from 12.8% at baseline to 29.1% after 6 h. DPC 6 h after TAVR showed a significant correlation with ΔvWF (r = − 0.254, p = 0.002). Patients with DPC > 20% had significantly higher ΔvWF (10.9% vs. 6.5%, p = 0.021). Obese patients showed a significantly lower DPC (11.8% vs. 19.9%, p = 0.001). In multivariate analysis, ΔvWF 6 h after TAVR was the only significant predictor for DPC > 20% (p = 0.017).ConclusionsThe restoration of vWF after TAVR is a significant predictor for DPC after TAVR. An increased platelet consumption due to vWF restoration could play a key role in the development of thrombocytopenia after TAVR.
Subacute cutaneous lupus erythematosus with a psoriasiform presentation: A diagnostic clinical conundrum
Authors: Razi Shazli , Truong Thu M. , Sekhon Palveen , Ouellette Samantha , Rao Babar K. 
Published: September 2023

Key Clinical MessageFor practitioners experiencing worsening psoriasis, subacute cutaneous lupus erythematosus (SCLE) with a psoriasiform presentation should be ruled out. Initial treatment for a presumptive diagnosis of psoriasis using hydroxychloroquine or ultraviolet phototherapy may cause SCLE to worsen.AbstractPsoriasiform subacute cutaneous lupus erythematosus is an unusual presentation scarcely reported in literature. We report a case of a 54‐year‐old man who presented with an itchy, papulosquamous rash of the upper extremities and face for 7 months. The initial physical examination revealed the classical morphology of psoriasis. One and a half years after the diagnosis of clinical worsening, the patient noticed a new papular eruption on the right posterior upper arm. A skin biopsy was performed, confirming a diagnosis of subacute cutaneous lupus erythematosus. This case report highlights the importance of considering rare presentations of cutaneous lupus erythematosus and therapeutic challenges in management.
Listeria peritonitis in a patient on hemodialysis for end‐stage renal disease secondary to lupus nephritis—a case report
Authors: Cox Victor Frederick , Perez‐Albela Alejandro , Ramirez Michael , Commins Ryan 
Published: September 2023

Key Clinical MessagePatients with a recent history of peritoneal dialysis catheter removal in the setting of immunosuppression should be monitored for rare Listeria bacterial peritonitis. This infection should be managed with ampicillin and gentamicin.AbstractThere are scattered reports to date of patients with peritonitis caused by Listeria monocytogenes. Listeria peritonitis is more commonly reported in patients with cirrhosis and those receiving peritoneal dialysis. We present a case of L. monocytogenes peritonitis in a patient with end‐stage renal disease due to lupus nephritis actively on hemodialysis months after peritoneal dialysis catheter removal.
Investigation of encapsulation of pancreatic beta cells and curcumin within alginate microcapsules
Authors: Hosseinzadeh Zahra , Alemzadeh Iran , Vossoughi Manouchehr 
Published: September 2023

AbstractCell encapsulation is an ideal approach for the replacement of pancreatic function in Type 1 diabetes. Poor biocompatibility of microcapsules generates an inflammatory response in the implantation site and induces fibrosis infiltration, which causes microencapsulated cell death and graft failure. To prevent inflammation after implantation, composite microcapsules that exhibit anti‐inflammatory properties were designed. This study is about encapsulating beta cells and curcumin within 1.5% alginate by the jet‐breaking regime of the syringe pump. The microcapsules’ size distribution and rate of the alginate solution were characterized to find uniform particles. Micro‐size particles were attained at a rate of 25 mL/min. Uniform spherical microcapsules (200–300 μm) were created in large amounts in a short period. Microcapsule breakage was less than 3% during 7 days, which demonstrated the stability of the encapsulation method. Insulin secretion and cell viability assays were performed 1, 3, and 7 days after microencapsulation by glucose‐stimulated insulin secretion (GSIS) and 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5 diphenyl tetrazolium bromide (MTT) assays. No significant differences in the amount of insulin secretion and beta cell viability were observed among free cells, alginate microcapsules, and curcumin‐alginate microcapsules during 7 days (p > 0.05). Therefore, the curcumin and alginate membrane did not show any harmful impacts on the function and survival of the beta cells.
Water‐Soluble Fullerene Monoderivatives for Biomedical Applications
Authors: Biswas Rohin , Batista Da Rocha Cassiana , Bennick Ryan A. , Zhang Jianyuan 
Published: September 2023

AbstractMonoderivatives of fullerenes functionalized with hydrophilic groups make them water soluble, while preserving the hydrophobic fullerene cage. This class of molecules have intriguing biomedical applications, including drug delivery, photodynamic therapy (PDT), antiviral and antimicrobial activity and reactive oxygen species (ROS)‐scavenging abilities. In this Concept we discuss the synthesis and biomedical applications of water‐soluble fullerene monoderivatives and their biological behavior based on their structures.