bluuebunny/crossref_metadata_2025_split huggingface dataset:
Five new limonoids isolated from Walsura robusta
Authors: Hou Li , Mei Cui-Xuan , Yuan Chun-Mao , Tang Gui-Hua , Chen Duo-Zhi , Zhao Qing , He Hong-Ping , Cao Ming-Ming , Hao Xiao-Jiang 
Published: February 2023

AbstractFive new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D (1–4), and one new furan ring degraded limonoid walsurobustone E (5) together with one known compound toonapubesic acid B (6) were isolated from the leaves of Walsura robusta. Their structures were elucidated by NMR and MS data. Especially, the absolute configuration of toonapubesic acid B (6) was confirmed by X-ray diffraction study. Compounds 1–6 exhibited good cytotoxicity against the cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480.
Disgust sensitivity and behavioural inhibitory systems in binge eating disorder: associations with eating pathology
Authors: Brassard Sarah L. , Laliberte Michele , MacKillop James , Balodis Iris M. 
Published: February 2023

AbstractDisgust sensitivity refers to how unpleasant a disgusting experience is to an individual and is involved in the development of many psychiatric conditions. Given its link with food ingestion, there is an interest in understanding how an individual’s susceptibility to disgust relates to dietary habits. One possible mechanism giving rise to this association is through the effects negative emotions have on high-order cognitive processes, but few studies take this model into account. The aim of this study was to characterize general disgust sensitivity in a clinical binge eating disorder (BED) population, and explore whether disgust sensitivity relates to inhibitory control and eating pathology. Following a case-controlled study design, our results show that: (1) disgust sensitivity and its subscales do not differ between BED and healthy controls, (2) higher disgust sensitivity in BED relates to greater behavioural inhibition, (3) inhibitory control reaction times relate to aspects of eating pathology, and (4) inhibitory control does not mediate relationships between disgust sensitivity and BMI among participants with BED. Understanding the role of disgust sensitivity in BED may allow us to understand how negative emotion systems maintain dysregulated eating behaviours with the potential to inform emotion-regulation treatment approaches. Level of evidence: Level III: Evidence obtained from well-designed cohort or case–control analytic studies.
Dysthyroid optic neuropathy: emerging treatment strategies
Authors: Pelewicz-Sowa M. , Miśkiewicz P. 
Published: February 2023

AbstractPurposeDysthyroid optic neuropathy (DON) is a rare sight-threatening complication of Graves’ disease. First-line treatment for DON consists of high-dose intravenous methylprednisolone (ivMP), followed by immediate orbital decompression (OD) if the response is poor or absent as recommended by the 2021 European Group on Graves’ orbitopathy guidelines. The safety and efficacy of the proposed therapy have been proven. However, consensus regarding possible therapeutic options for patients with contraindications to ivMP/OD or resistant form of disease is missing. This paper aims to provide and summarize all available data regarding possible alternative treatment strategies for DON.MethodsA comprehensive literature search within an electronic database was performed including data published until December 2022.ResultsOverall, 52 articles describing use of emerging therapeutic strategies for DON were identified. Collected evidence indicates that biologics, including teprotumumab and tocilizumab, may be considered as an important possible treatment option for DON patients. Rituximab should be avoided in DON due to conflicting data and risk of adverse events. Orbital radiotherapy could be beneficial for patients with restricted ocular motility classified as poor surgical candidates.ConclusionOnly a limited number of studies have been dedicated to the therapy of DON, mostly retrospective with a small sample size. Clear criteria regarding diagnosis and resolution of DON do not exist, which restricts comparison of therapeutic outcomes. Randomized clinical trials and comparison studies with long-term follow-ups are necessary to verify the safety and efficacy of each therapeutic option for DON.
A Proposed Curricular Framework for an Interprofessional Approach to Deprescribing
Authors: Farrell Barbara , Raman-Wilms Lalitha , Sadowski Cheryl A. , Mallery Laurie , Turner Justin , Gagnon Camille , Cole Mollie , Grill Allan , Isenor Jennifer E. , Mangin Dee , McCarthy Lisa M. , Schuster Brenda , Sirois Caroline , Sun Winnie , Upshur Ross 
Published: February 2023

Abstract
Deprescribing involves reducing or stopping medications that are causing more harm than good or are no longer needed. It is an important approach to managing polypharmacy, yet healthcare professionals identify many barriers. We present a proposed pre-licensure competency framework that describes essential knowledge, teaching strategies, and assessment protocols to promote interprofessional deprescribing skills. The framework considers how to involve patients and care partners in deprescribing decisions. An action plan and example curriculum mapping exercise are included to help educators assess their curricula, and select and implement these concepts and strategies within their programs to ensure learners graduate with competencies to manage increasingly complex medication regimens as people age.
Integral and Weighted Composition Operators on Fock-type Spaces
Authors: Mengestie Tesfa , Takele Mollalgn Haile 
Published: February 2023

AbstractWe study various structures of general Volterra-type integral and weighted composition operators acting between two Fock-type spaces $$\mathcal {F}_{\varphi }^p$$

F

φ

p

and $$\mathcal {F}_{\varphi }^q,$$

F

φ

q

,

where $$\varphi $$
φ
is a radial function growing faster than the function $$z\rightarrow |z|^2/2$$

z
→

|
z
|

2

/
2

. The main results show that the unboundedness of the Laplacian of $$\varphi $$
φ
provides interesting results on the topological and spectral structures of the operators in contrast to their actions on Fock spaces, where the Laplacian of the weight function is bounded. We further describe the invertible and unitary weighted composition operators. Finally, we show the spaces support no supercyclic weighted composition operator with respect to the pointwise convergence topology and hence with the weak and strong topologies.
Evolution characteristics of acoustic emission and strain energy for deep granite under different damage stages
Authors: Wang Chuanle , Du Guangyin , Han Yang , He Kang , Li Erbing 
Published: February 2023

AbstractThe first underground research laboratory (URL) as the research platform for the deep geological disposal of high-level radioactive waste (HLW) in China is being built in a deep granite rock mass. The damaged characteristics and mechanical properties of the deep granite under loading seriously influence the URL’s construction safety and disposal function for HLW. Therefore, this paper investigates the damaged characteristics and mechanical properties of the Beishan deep granite used in various confining pressure levels through a series of triaxial compression and acoustic emission (AE) tests. Based on the crack volumetric strain model, the crack stress thresholds of the deep granite specimens under various confining pressure levels were acquired. The damage development of the specimens used in five confining pressure conditions was analyzed, and the evolution of AE parameters and strain energy of the deep rock under different damage stages were explored. The studied results shown that the crack stress thresholds of the deep granite rose linearly with the increasing confining pressure, but their stress ratios remained relatively constant under various confining pressure levels. Under the rock loading tests, the designed confining pressure levels influenced the AE hit count and AE accumulative count development under the rock damage process. The high-frequency points of the AE hit count coincide with the AE accumulative count increasing, and the maximum value of the AE hit count of the specimens used in different confining pressure conditions appears in the postpeak stress‒strain stage. Additionally, with the axial strain of the loading rock rising in the prepeak stress‒strain stage, all the strain energy (including total energy U, elastic energy Ue and dissipated energy Ud) continues to rise, and in the postpeak stress‒strain stage, Ue stored inside the rock is quickly released, resulting in the Ue/U decreasing and Ud/U increasing.
Wettbewerb in der digitalen Ökonomie
Authors: Wambach Achim 
Published: February 2023

ZusammenfassungEs gibt kaum ein Thema in der Wirtschaftspolitik, das weltweit so viele Kommissionen, Ausschüsse und ad-hoc Gremien beschäftigt hat, wie die Frage nach der „richtigen“ Wettbewerbspolitik in der digitalen Welt. Auch die Wirtschaftswissenschaften haben sich darauf eingestellt: Ein ganzer Forschungszweig, die Industrieökonomik, hat sich mittlerweile zu großen Teilen der Erforschung von digitalen Plattformen verschrieben. In diesem Beitrag gehe ich auf die ökonomischen Grundlagen der digitalen Ökonomie ein, die ein Umdenken in der Wettbewerbspolitik notwendig machten. In einem zweiten Schritt diskutiere ich ausgewählte Aspekte der legislativen Reformen in Deutschland und Europa unter Berücksichtigung der ökonomischen Grundlagen. Die Arbeit endet mit einem Ausblick auf die 11. Novelle des Gesetzes gegen Wettbewerbsbeschränkungen.
Neutrino transport in general relativistic neutron star merger simulations
Authors: Foucart Francois 
Published: February 2023

AbstractNumerical simulations of neutron star–neutron star and neutron star–black hole binaries play an important role in our ability to model gravitational-wave and electromagnetic signals powered by these systems. These simulations have to take into account a wide range of physical processes including general relativity, magnetohydrodynamics, and neutrino radiation transport. The latter is particularly important in order to understand the properties of the matter ejected by many mergers, the optical/infrared signals powered by nuclear reactions in the ejecta, and the contribution of that ejecta to astrophysical nucleosynthesis. However, accurate evolutions of the neutrino transport equations that include all relevant physical processes remain beyond our current reach. In this review, I will discuss the current state of neutrino modeling in general relativistic simulations of neutron star mergers and of their post-merger remnants. I will focus on the three main types of algorithms used in simulations so far: leakage, moments, and Monte-Carlo scheme. I will review the advantages and limitations of each scheme, as well as the various neutrino–matter interactions that should be included in simulations. We will see that the quality of the treatment of neutrinos in merger simulations has greatly increased over the last decade, but also that many potentially important interactions remain difficult to take into account in simulations (pair annihilation, oscillations, inelastic scattering).
Wer leitet die deutschen Bildungsministerien? Ein neuer Datensatz zur Analyse von biografischen Merkmalen von Bildungsminister:innen der Bundesländer, 1950–2020
Authors: Irmert Natalie , Mummert Kaja , Nikolai Rita , Mergele Lukas , Zierow Larissa 
Published: February 2023

ZusammenfassungDieser Beitrag untersucht, wer in Deutschland Bildungsminister:in wird. Zur Klärung dieser Frage entwickelten wir einen Datensatz, der die biografischen Merkmale aller Bildungsminister:innen der deutschen Bundesländer zwischen 1950 und 2020 enthält. Als Beispiel für die Nutzung des Datensatzes untersuchen wir die beiden Merkmale Geschlecht und frühere Berufserfahrung und verknüpfen diese Merkmale mit Indikatoren für die Größe und Entwicklung des Bildungsbudgets und die Dauer der Amtszeit. Wir zeigen, dass zwischen 1950 und 2020 deutlich mehr Männer als Frauen zum/zur Bildungsminister:in ernannt wurden, unabhängig davon, welche Parteien die Bildungsminister:innen stellten. Außerdem verfügt die Mehrheit der Bildungsminister:innen bei Amtsantritt nicht über vorherige Berufserfahrung als Lehrer:in. Die meisten Bildungsminister:innen haben jedoch bereits politische Erfahrung, wenn sie ihr Amt antreten. Unsere Datenbank, die die erste umfassende Erhebung biografischer Merkmale von Bildungsminister:innen in den deutschen Bundesländern enthält, steht allen interessierten Forscher:innen zur Verfügung.
‘Why haven’t you known?’
Authors: Eschle Catherine 
Published: February 2023

AbstractThis article critically examines the character and extent of transoceanic solidarity in feminist anti-nuclear activism. Drawing on archival research into a British-based solidarity network, Women Working for a Nuclear Free and Independent Pacific (WWNFIP), the article centralises the rhetorical question ‘Why Haven’t You Known?’ demanded by Māori activist Titewhai Harawira of her British audience in 1986, and extends it to contemporary scholars of feminist anti-nuclear activism. The article makes three main empirical claims. First, the WWNFIP archive pushes Indigenous women from across the Pacific into the limelight as experts and teachers, with British-based counterparts playing a supportive role. Second, the archive foregrounds Indigenous knowledge claims about nuclear colonialism and correspondingly represents decolonisation as essential to nuclear abolition. Thirdly, solidarity is shaped in ambivalent ways by these knowledge claims, which simultaneously evoke sisterly closeness and the discomfort of potential white allies. Overall, WWNFIP’s relatively successful construction of transoceanic solidarity, notwithstanding some ambiguities and limitations, points to the crucial relationship between knowledge and solidarity. The case study not only offers some valuable lessons for contemporary efforts to forge anti-nuclear solidarities but also disrupts dominant accounts of feminist anti-nuclear activism, past and present.
A lipid droplet-associated protein Nem1 regulates appressorium function for infection of Magnaporthe oryzae
Authors: Chen Deng , Cai Xuan , Xing Junjie , Chen Shen , Zhao Juan , Qu Zhiguang , Li Guotian , Liu Hao , Zheng Lu , Huang Junbin , Chen Xiao-Lin 
Published: February 2023

AbstractLipid droplets are important storages in fungal conidia and can be used by plant pathogenic fungi for infection. However, the regulatory mechanism of lipid droplets formation and the utilization during fungal development and infection are largely unknown. Here, in Magnaporthe oryzae, we identified a lipid droplet-associated protein Nem1 that played a key role in lipid droplets biogenesis and utilization. Nem1 was highly expressed in conidia, but lowly expressed in appressoria, and its encoded protein was localized to lipid droplets. Deletion of NEM1 resulted in reduced numbers of lipid droplets and decreased content of diacylglycerol (DAG) or triacylglycerol (TAG). NEM1 was required for asexual development especially conidia production. The Δnem1 mutant was nearly loss of virulence to host plants due to defects in appressorial penetration and invasive growth. Remarkably, Nem1 was regulated by the TOR signaling pathway and involved in the autophagy process. The Ser303 residue of Nem1 could be phosphorylated by the cAMP-PKA signaling pathway and was important for biological function of Nem1. Together, our study revealed a regulatory mechanism of lipid biogenesis and metabolism during the conidium and appressorium formation of the rice blast fungus.
Cross-Toeplitz operators on the Fock–Segal–Bargmann spaces and two-sided convolutions on the Heisenberg group
Authors: Kisil Vladimir V. 
Published: February 2023

AbstractWe introduce an extended class of cross-Toeplitz operators which act between Fock–Segal–Bargmann spaces with different weights. It is natural to consider these operators in the framework of representation theory of the Heisenberg group. Our main technique is representation of cross-Toeplitz by two-sided relative convolutions from the Heisenberg group. In turn, two-sided convolutions are reduced to usual (one-sided) convolutions on the Heisenberg group of the doubled dimensionality. This allows us to utilise the powerful group-representation technique of coherent states, co- and contra-variant transforms, twisted convolutions, symplectic Fourier transform, etc. We discuss connections of (cross-)Toeplitz operators with pseudo-differential operators, localisation operators in time–frequency analysis, and characterisation of kernels in terms of ladder operators. The paper is written in a detailed and reasonably self-contained manner to be suitable as an introduction into group-theoretical methods in phase space and time–frequency operator theory.
Acceptability of serosurveys in southern Zambia: data collector and caregiver perspectives
Authors: Carcelen Andrea C. , Limaye Rupali J. , Mutembo Simon , Hamahuwa Mutinta , Thuma Philip E. , Moss William J. , Hayford Kyla 
Published: February 2023

Abstract
Background
Factors associated with whether individuals choose to participate in serosurveys are not well understood. Understanding perceptions from multiple perspectives, including the perspectives of both data collectors and participants, through a holistic model such as the socio-ecological model contextualizes individual, interpersonal, and structural level influences on survey research participation. We used a multiple methods approach to characterize reasons for serosurvey participation in communities in Southern Province, Zambia where a serosurvey was conducted in 2016.

Methods
The first phase conducted focus group discussions and in-depth interviews with 24 data collectors who participated in a measles-rubella serosurvey in 2016. The second phase surveyed 34 caregivers at health facilities to identify barriers and facilitators to serosurvey participation. Emergent themes were then classified into a socio-ecological model using individual, interpersonal, and structural level constructs.

Results
Common themes emerged from data collectors as well as caregivers surveyed. At the individual level, providing incentives was a facilitator, and some religious beliefs were described as a barrier to serosurvey participation. At the interpersonal level, family dynamics and community peer influences could help or hinder serosurvey participation. Community health workers were consistently named as facilitators of participation. At the structural level, concerns about specimen collection, who was selected for serosurveys, and not receiving test results arose as potential barriers. The most frequently reported facilitator was provision of information about the purpose of the serosurvey (85% of respondents). The most frequently reported barrier was lack of clarity regarding use of their blood specimen (53% of respondents). For specimen collection type, caregivers consistently preferred finger prick blood collection over both venous blood draw and oral swabs.

Conclusion
Serosurvey participation was deemed acceptable to most study participants. The socio-ecological model revealed barriers and facilitators for participation to guide strategies to improve participation which can be applied to ongoing serosurveys for SARS-CoV-2. Serosurveys should continue to develop engagement plans to provide information about blood collection ahead of the serosurvey and communicate the objectives of such studies through trusted sources such as community health workers and traditional leaders.
Traditional fermented foods of Benin Republic: microbiological safety and health benefits
Authors: Zannou Oscar , Chabi Ifagbémi B. , Kpoclou Yénoukounmè E. , Kayodé Adéchola P. P. , Galanakis Charis M. , Selli Serkan 
Published: February 2023

AbstractA wide range of traditional fermented foods is produced and prized in communities in developing countries. Due to the generation of beneficial microorganisms, nutritional and bioactive compounds such as organic acids, antioxidants, enzymes, vitamins, minerals, high bioavailable proteins, peptides, mannans, β-glucans and amino-acids, fermentation has been considered one of most vital food processing techniques to improve product shelf life, quality, and safety. The presented overview of scientific research emphasizes the microflora potential and multifold advantageous effects of the fermented foods traditionally produced in the Benin Republic. Several innovative scientific investigations on fermentation and fermented products, together with indigenous knowledge and professional experience, have been explored and discussed. The characterization of microbiological aspects of these foods revealed that they present economic, nutritional, and health advantages with essential prebiotics and probiotics for the indigenous communities. Furthermore, traditional fermented foods have high safety and quality. However, the industrial way is suggested to limit the eventual adverse contaminations.
Large variations of crustal thickness across the Taiwan orogeny constrained by Moho-refraction recorded by the Formosa Array
Authors: Shih Min-Hung , Lai Ya-Chuan , Lin Cheng-Horng 
Published: February 2023

AbstractThe Taiwan orogenic belt is formed by the strong convergence between the Philippine Sea Plate and the Eurasian Plate. The detailed mountain building process is still under debated largely due to the poor constraint of deep crustal structures, particularly the geometry at the Moho-depth. Here the Moho-refracted P waves are identified from the seismic data recorded by a dense seismic array (Formosa Array) in northern Taiwan. Although the refracted seismic energy is often weak at each individual station, the waveform similarity recorded at the nearby stations provides a reliable constraint for estimating the apparent velocity recorded by the dense seismic array. The forward modeling of the observed Moho-refracted P waves shows a larger crustal thickness (~ 52 km) beneath the Backbone Ranges than beneath the adjacent Hsuehshan Ranges (~ 36 km). Such a result is not only confirming the Moho variations along a few of the NW-SE profiles from the previous studies, but also showing the strong Moho variation is well extended along the NE-SW direction. The large change in the crustal thickness across the Taiwan orogeny strongly indicate that the orogenic deformation in Taiwan might extend beyond the shallow crust, possibly involving in the deep crust and upper mantle. The Taiwan orogeny may not be reaching to the isostatic equilibrium yet.