bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing Oral Bioavailability of Domperidone Maleate: Formulation,
In vitro Permeability Evaluation In-caco-2 Cell Monolayers and In situ Rat
Intestinal Permeability Studies
Authors: Okur Neslihan Üstündağ , Çağlar Emre Şefik , Kaynak Mustafa Sinan , Diril Mine , Özcan Saniye , Karasulu Hatice Yeşim 
Published: February 2023

Background:
The domperidone maleate, a lipophilic agent classified as a Biopharmaceutical
Classification System Class II substance with weak water solubility. Self- Emulsifying Drug Delivery
System is a novel approach to improve water solubility and, ultimately bioavailability of drugs.

Objective:
This study aimed to develop and characterize new domperidone-loaded self-emulsifying drug
delivery systems as an alternative formulation and to evaluate the permeability of domperidone-loaded
self-emulsifying drug delivery systems by using Caco-2 cells and via single-pass intestinal perfusion
method.

Methods:
Three self-emulsifying drug delivery systems were prepared and characterized in terms of pH,
viscosity, droplet size, zeta potential, polydispersity index, conductivity, etc. Each formulation underwent
10, 100, 200, and 500 times dilution in intestinal buffer pH 6.8 and stomach buffer pH 1.2, respectively.
Female Sprague Dawley rats were employed for in situ single-pass intestinal perfusion investigations.

Results:
Results of the study revealed that the ideal self-emulsifying drug delivery systems formulation
showed narrow droplet size, ideal zeta potential, and no conductivity. Additionally, as compared to the
control groups, the optimum formulation had better apparent permeability (12.74 ± 0.02×10-4) from
Caco-2 cell monolayer permeability experiments. The study also revealed greater Peff values (2.122 ±
0.892×10-4 cm/s) for the optimal formulation from in situ intestinal perfusion analyses in comparison to
control groups (Domperidone; 0.802 ± 0.418×10-4 cm/s).

Conclusion:
To conclude, prepared formulations can be a promising way of oral administration of Biopharmaceutical
Classification System Class II drugs.
Bibliometric Analysis of Research in Pediatrics Related to Virtual and
Augmented Reality: A Systematic Review
Authors: Kacmaz Kevser Sevik , Kaçmaz Cihangir 
Published: February 2023

Introduction:
The amount of research exploring the use of virtual reality (VR) and aug-mented reality (AR) technologies in health care has exploded. This has resulted in a massive body of work, making it difficult to obtain all of the research. The objective of this study was to map out and put together the scientific output of research and global trends in virtual and AR in pediatrics.

Methods:
Publications were collected from the Web of Science (WoS) database. The R tool was used to categorize and evaluate the research outputs, as well as the most productive and influential countries, journals, institutions, authors, articles, subject areas, and the latest research themes. The most utilized and co-occurring keywords were also examined. Texts, tables, and images were used to assess and describe the retrieval of findings.

Results:
The research was based on information from 7423 publications. The strongest growth in publications occurred in 2020. The most productive and influential country was the USA. The jour-nal was Pediatrics, the author was G Riva, and the institution was the University of Washington. The most frequently occurring keywords were simulation, rehabilitation, and stroke. The main re-search themes were therapy, surgical education, and rehabilitation. Pain, stroke, anxiety, depression, fear, dementia, and neurodegenerative illnesses were all common medical issues investigated.

Conclusion:
VR studies have mainly focused on surgical education or procedures, simulation technologies,
and neurological conditions. Neurological conditions are linked to balance, gait, and rehabilitation,
reflecting the prevalence of these disease groups.

:
This article provides a thorough overview of VR and AR studies in the healthcare field. This work
will allow academics, policymakers, and practitioners to gain a deeper understanding of the evolution
of VR and AR studies in the healthcare field and its potential practical implications. Future VR
and AR research should focus on bridging the gap between VR and AR healthcare research and
clinical applications. Emerging trends in related fields, such as navigation, rehabilitation, stroke,
dementia, and VR exposure therapy, should be given special attention.
Picoscience: Picotechnology’s Advent in Health and Medicine
Authors: Bhagawati Hrishikesh , Kashyap Sarma Mrinal , Talukder Abhijita , Das Sumanjit , Nath Debabrata 
Published: February 2023

Abstract:
As the human race evolves, numerous diseases have dominated humans, causing scientists to
encounter myriad challenges with formulations. To rectify these issues, Nanoparticle (10-9 m) formulation
approach or nanotechnology has been developed. Since nanoparticles have legion benefits, encompassing
better bioavailability, target-specific, confined, accurate dose delivery, and increased surface area,
are pertinent for effective treatment. Toxicity, inflammation, limited penetrating ability, accumulation,
and aggregation are some of the downsides of nanoparticles. Picoscale along with nanoparticle
technology in drug delivery, will enhance the permeability and myriad factors. Also, picometer (10-12 m)
and futuristic femtometer (10-15 m) particles will allow scientists to deal with atomic and subatomic levels
in some cases and improve the properties of nanotechnology in others. Herein, picotechnology, formulation,
synthesis, and some unique properties concluding with femtotechnology have been addressed.
A pilot case crossover study of the use of padded headgear in junior Australian football
Authors: Willmott Catherine , Reyes Jonathan , Nguyen Jack VK , McIntosh Andrew , Makovec-Knight Jennifer , Makdissi Michael , Clifton Patrick , Harcourt Peter , Mitra Biswadev 
Published: February 2023

Aim: To explore soft-shell padded headgear (HG) use, player behavior and injuries associated with HG in junior Australian football. Methods: Prospective case-crossover with head impact measurement, injury surveillance and video review. Results: 40 players (mean age: 12.43 years, standard deviation: 1.36) across 15 matches were observed. Frequency of head/neck (p = 0.916) or body (p = 0.883) contact events, and match incidents were similar between HG and no HG conditions. Without HG, females had higher frequency of body contacts compared with males (p = 0.015). Males sustained more body contacts with HG than without HG (p = 0.013). Conclusion: Use of HG in junior football was not associated with injury or head contact rate. Associations between HG use and body contact may differ across sexes. (ID: ACTRN12619001165178).
Peran Technopreneurs dalam Komersialiasi Teknologi Konverter Kit Motor Listrik (Studi Kasus: PT. EKM)
Authors: Putra Muhammad Iqbal Sulistyo , Al Banna Wafiq Hasan , Afraah Sayyidah Maulidatul , Yuniaristanto Yuniaristanto , Liquiddanu Eko , Sutopo Wahyudi 
Published: February 2023

Most of the technology from universities (PT) related to technological innovation often fails to enter the market. This problem then becomes the basis and object of improvement in technology-based entrepreneurial practices (technopreneurs). Learning is carried out through Independence Learning Campus Independence (MBKM) which converts courses according to training subjects in collaboration with PUI UNS and BPPT. This practice is a model of participatory and collaborative learning, in which students are directly involved in solving existing case studies and act as perpetrators of technology commercialization and become technopreneurs. Students are initially given training materials in accordance with the curriculum and direct learning from existing tenants. As a result, through this learning process, students can design business process proposals that exist in tenants. The success of this learning method was assessed based on technopreneur analysis from students in answering problems faced by tenants based on aspects of product technology innovation, product development, business development, and its implementation at BMC. One of the tenants who is the object of the case study in this study is the start-up PT. EKM who have problems with the commercialization of technology in the case of konverter kit products.
Seleksi dan Penentuan Third Party Logistik Transportasi Produk Pelumas Menggunakan Metode TOPSIS dan PROMETHE
Authors: Hasibuan Sawarni , Jaqin Choesnul 
Published: February 2023

Selection of Third Party Logistics (3PL) services is an important focus of attention for companies in selecting suppliers in their supply chain. The wide marketing area of PT PETRONAS's lubricant products demands 3PL performance to increase the company's service level. The purpose of this study is to analyze the decision-making process in the context of selecting 3PL transportation suppliers using the TOPSIS and PROMETHE multi-criteria methods. The type of data used consists of primary data and secondary data through library research, interviews, and field surveys. The process of selecting a transportation 3PL is carried out in two stages, namely selection of criteria and the commercial aspect of the bidding price per region is evaluated as the basis for selecting the best supplier. The selected suppliers are PT Wira Logitama Saksama, PT Glory sogotrans Mandiri, PT Iron Bird Logistik, PT Sumisho Global Logistik, and PT Dunia Express Transindo. Based on the results of the analysis using the PROMETHEE method, five criteria with the highest weight were produced, namely Price, Time Delivery, Health Safety Management, Infrastructure and Office Equipment. The results of the ranking using the TOPSIS method for shipping to each destination are that PT Wira Logitama Semesta is the best supplier for five shipping destinations, namely Jabodetabek, Bandung, Surabaya, Lampung and Medan and PT Iron Bird Logistik is the best supplier for shipping to Cilegon and Semarang.
Application Tip and Concentration of a Self-mixing Bleach: Hydrogen Peroxide Inside the Pulp Chamber, Color Change, and Amount of Bleaching Gel Used
Authors: Carneiro TS , Favoreto MW , Bernardi LG , Bandeca MC , Borges CPF , Reis A , Loguercio AD 
Published: February 2023

SUMMARYPurposeThe objective of this study was to evaluate if the application method (tip with brush or tip without brush) and hydrogen peroxide (HP) concentration (6% or 35% self-mixing) of in-office bleaching gel influences the penetration of HP into the pulp chamber, color change, and the amount of bleaching gel used.MethodsForty healthy premolars were randomly divided into the following five groups (n=8): no treatment; HP6% using a tip with a brush, HP6% using a tip without a brush, HP35% using a tip with a brush, and HP35% using a tip without a brush. After treatments, the HP concentration (μg/mL) within the pulp chamber was determined using UV-Vis spectrophotometry. The color change (ΔEab, ΔE00, and ΔWID) was evaluated using a digital spectrophotometer. The amount of gel used (g) in each group was measured using a precision analytical balance. Data from each test were submitted to parametric tests (α=0.05).ResultsThe tip with a brush resulted in a lower amount of HP inside the pulp chamber and less gel used when compared with the tip without a brush, regardless of HP concentration (p&lt;0.05). However, regarding the tip used, although no significant difference was observed when HP35% was used (p&gt;0.05), a higher whitening effect was observed when the 6% HP was applied without a brush as opposed to with a tip brush (p&lt;0.05).ConclusionsThe use of a tip with a brush, regardless of the in-office bleaching gel concentration (6% or 35% self-mixing), presented a lower penetration and lower volume of spent gel when compared to a tip without brush. However, the whitening effect depended on the concentration of HP used.
Effect of Salivary Flow on Bleached Enamel Roughness and Mineral Content: anIn SituandIn VitroStudy
Authors: Hauss Monteiro DD , Elias DC , Costa RFO , Carvalho MFF , Ferreira RC , Moreira AN , Magalhães CS 
Published: February 2023

SUMMARYThis study aimed to evaluate the effect of human saliva in vitro and salivary flow in situ on the roughness and mineral content of bleached enamel. Dental specimens were divided into five groups (n=15): not bleached (NB); bleached (35% hydrogen peroxide) and exposed to distilled water (DW); human saliva in vitro (IV); normal salivary flow in situ (NSF); and low salivary flow (LSF) in situ. Enamel roughness (Ra, Rz) and calcium/phosphorus contents were evaluated with laser profilometry and energy-dispersive spectroscopy, respectively, at baseline (T1), after bleaching (T2), and after seven days (T3). Salivary pH and buffer capacity were evaluated with colorimetric strips and salivary calcium and phosphorus with absorbance spectrophotometry. Data were analyzed with non-parametric tests and linear regression (α=0.05). After contact with saliva, Ra and Rz of LSF=DW&gt;IV=NSF=NB was found. For DW and LSF, the roughness of T1&lt;T2=T3 was found. For IV, T1&lt;T3&lt;T2; for NSF, T1=T3&lt;T2. Enamel calcium/phosphorus content did not change with bleaching or with saliva contact (p≥0.05). Buffer capacity and calcium concentration did not differ between LSF and NSF. Phosphorus was higher, and pH was lower in LSF. Ra and Rz were, respectively, 0.14 and 1.95 lower with NSF than LSF. The conclusions were that NSF in situ and human saliva in vitro recovered original enamel roughness. The experimental conditions did not affect enamel mineral content. Recovery of bleached enamel roughness was higher in NSF when compared to LSF, regardless of salivary pH, calcium and phosphorus concentrations, and buffer capacity.
Media Video Pembelajaran Berbasis Video Scribe Pada IPA Kelas V Sekolah Dasar
Authors: Rezaldi  , I Made Citra Wibawa  , Made Vina Arie Paramita  
Published: February 2023

Dalam penerapannya, media belajar belum digunakan secara optimal. Selain itu guru juga menyampaikan materi hanya dengan ceramah. Hal ini tentu akan menyulitkan siswa dalam memahami materi pembelajaran. Tujuan penelitian ini yaitu mengembangkan video pembelajaran berbasis videoscribe pada mata pelajaran IPA untuk siswa kelas V SD. Jenis penelitian ini yaitu penelitian pengembangan dengan menggunakan model ADDIE. Model pengembangan ADDIE. Subjek penelitian yaitu 1 ahli media,1 ahli materi dan 2 praktisi. Metode pengumpulan data mengggunakan observasi, dan kuesioner. Instrument yang digunakan dalam mengumpulkan data yaitu rating scale. Teknik yang digunakan untuk menganalisis data yaitu analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian yaitu hasil penilaian yag diberikan pada ahli materi pembelajaran yaitu 4,75, sehingga mendapatkan kualifikasi sangat baik. Penilaian yang diberikan oleh ahli media pembelajaran yaitu 4,75 sehingga mendapatkan kualifikasi sangat baik. Penilaian yang diberikan oleh guru yaitu 4,83 sehingga mendapatkan kualifikasi sangat baik. Disimpulkan bahwa Video Berbasis Videoscibe valid dan layak digunakan dalam pembelajaran. Implikasi penelitian ini yaitu video pembelajaran berbasis Videosribe yang telah dikembangkan dapat membantu siswa belajar IPA.
UPAYA PENINGKATAN KEMAMPUAN GURU PAK DALAM MEMPERSIAPKAN RPP MELALUI SUPERVISI METODE FOCUS GROUP DISCUSSION DI SMP SE-KECAMATAN MEDAN JOHOR KOTA MEDAN
Authors: Manik Chandra 
Published: February 2023

Abstrak : Upaya Peningkatan Kemampuan Guru PAK Dalam Mempersiapkan RPP Melalui Supervisi Metode Focus Group Discussion Di Smp Se-Kecamatan Medan Johor Kota Medan. Latar belakang penelitian ini adalah rendahnya kemampuan guru pengampu mata pelajaran Pendidikan Agama Kristen dalam mempersiapkan Rencana Pelaksanaan Pembelajaran (RPP). Masih banyak guru yang belum paham dan termotivasi dalam menyusun Rencana Pelaksanaan Pembelajaran dengan lengkap. Dengan metode Focus Group Discussion, guru dituntut ikut terlibat secara langsung dalam diskusi sesuai skenario yang disusun. Penelitian ini merupakan Penelitian Tindakan Sekolah (PTS). Teknik pengumpulan data yang digunakan dalam penelitian ini berupa format rubrik penilaian. Hasil penelitian menunjukan adanya peningkatan kompetensi guru dalam menyusun RPP yang terlihat dari hasil penilaian dari Siklus I ke Siklus II. Kata kunci : Rencana Pelaksanaan Pembelajaran, Focus Group Discussion
PENINGKATAN AKTIVITAS BELAJAR PKN SISWA MELALUI PENERAPAN MODEL PEMBELAJARAN THINK TALK WRITE (TTW) DI KELAS VII-1 SMP NEGERI 1 BARUSJAHE
Authors: Sitepu Lekton 
Published: February 2023

Abstrak : Peningkatan Aktivitas Belajar Pkn Siswa Melalui Penerapan Model Pembelajaran Think Talk Write(TTW) Di Kelas VII-1 SMP Negeri 1Barusjahe. Penelitianbertujuan untuk meningkatkan hasil belajar aktivitas belajar PKn siswa kelas VII-1 SMP Negeri 1 Barusjahe dengan penerapan model pembelajaran Think Talk Write (TTW).Subjek penelitian berjumlah 28 siswa.Data aktivitas siswa pada Siklus I antara lain membaca dan menulis (39%), Mengerjakan LKS (27%), bertanya sesama teman (17%), bertanya kepada guru (9%), dan yang tidak relevan dengan KBM (8%). Pada Siklus II, menulis dan membaca (23%), Mengerjakan LKS (38%), bertanya sesama teman (16%), bertanya kepada guru (5%), dan yang tidak relevan dengan KBM (3%). Sehingga aktivitas siswa mengalami perbaikan dari Siklus I ke Siklus II.Nilai rata-rata pada siklus I adalah 73 dan siklus II adalah 86. Siswa tuntas pada siklus I adalah 17 siswa (57,14%) dan siklus II adalah 24 siswa (85,71%). Kata Kunci :Model Think Talk Write (TTW), Hasil Belajar, Aktivitas Belajar
The Development of a National Sport Event Management Model that Affects the Value Added of the Sport Industry in Thailand
Authors: Singcram Patantiya , Thanaiudompat Thanarit 
Published: February 2023

The objective of this study was to construct a model of the link between sports resources and the model of national sports event management and the added value of Thailand's sports sector. Mixed methods were implemented in this study. The causative and result link between sports resource variables and national sporting practices and the added value of the Thai sports sector were examined using quantitative research. Using questionnaires and qualitative phenomenological research, data were obtained from 207 sports competition management organizations registered with the Department of Business Development in 2020. Based on in-depth interviews, a group discussion with the Council of Industry Committees was implemented to corroborate the results of the in-depth interviews. The sports industry group comprised of three individuals and two academics in sports business management who conducted a corroborative elemental analysis on the data. And structural equation models. The hypothesis research found that 1) sports resources had a direct effect on the value added of the sports industry and an indirect effect on the value added of the sports industry through the national sports competition management; 2) the sports resources had a direct effect on the national sports competition management; and 3) the national sports competition management had a direct effect on the added value of the sports industry in Thailand. The analysis revealed that the hypothetical model was consistent with the statistical data. It appeared to be qualified with χ2 = 47.85, p-value = 0.08, χ2/df = 1.55, GFI = 0.96, AGFI = 0.98, and RMSEA = 0.01. The contribution of this research is that it can explain the relationship between the causes and outcomes of sports resources and guidelines for organizing national sports events and the added value of the sports industry in Thailand. The results of the study can be used in the management of sports competition management businesses, which leads to sustainable performance for the sports industry. Doi: 10.28991/ESJ-2023-07-02-010 Full Text: PDF
Batch and Streaming Data Ingestion towards Creating Holistic Health Records
Authors: Mavrogiorgou Argyro , Kiourtis Athanasios , Manias George , Symvoulidis Chrysostomos , Kyriazis Dimosthenis 
Published: February 2023

The healthcare sector has been moving toward Electronic Health Record (EHR) systems that produce enormous amounts of healthcare data due to the increased emphasis on getting the appropriate information to the right person, wherever they are, at any time. This highlights the need for a holistic approach to ingest, exploit, and manage these huge amounts of data for achieving better health management and promotion in general. This manuscript proposes such an approach, providing a mechanism allowing all health ecosystem entities to obtain actionable knowledge from heterogeneous data in a multimodal way. The mechanism includes diverse techniques for automatically ingesting healthcare-related information from heterogeneous sources that produce batch/streaming data, managing, fusing, and aggregating this data into new data structures (i.e., Holistic Health Records (HHRs)). The latter enable the aggregation of data coming from different sources, such as Internet of Medical Things (IoMT) devices, online/offline platforms, while to effectively construct the HHRs, the mechanism develops various data management techniques covering the overall data path, from data acquisition and cleaning to data integration, modelling, and interpretation. The mechanism has been evaluated upon different healthcare scenarios, ranging from hospital-retrieved data to patient platforms, combined with data obtained from IoMT devices, having produced useful insights towards its successful and wide adaptation in this domain. In order to implement a paradigm shift from heterogeneous and independent data sources, limited data exploitation, and health records, the mechanism has combined multidisciplinary technologies toward HHRs. Doi: 10.28991/ESJ-2023-07-02-03 Full Text: PDF
Recambio por aféresis de glóbulos rojos. Primer Registro de un Hospital Pediátrico en Quito-Ecuador
Authors: Asimbaya Alvarado Danny , Maria Dolores Nieto 
Published: February 2023

Introducción: La anemia falciforme es la hemoglobinopatía estructural más frecuente en todo el mundo y es causada por la producción de hemoglobina S (HbS) a consecuencia de una mutación puntual en el gen de la beta globina.
Objetivo: Mostrar los beneficios del recambio de glóbulos rojos por aféresis en la presentación del síndrome torácico agudo, causado por la anemia drepanocítica.
Presentación del caso: Se describe el manejo de una paciente de trece años de edad, con anemia drepanocítica que, al momento de su ingreso al hospital, presentó crisis vaso- oclusiva secundaria a su patología de base. Al segundo día presentó síndrome de tórax agudo, por lo que se solicitó al Servicio de Medicina Transfusional, el recambio eritrocitario. Analizado el caso, se realizó el cálculo de la volemia total de la paciente, se prepararon concentrados de glóbulos rojos (CGRs) compatibles con la paciente: se filtraron; y se les cuantificó el hematocrito. El procedimiento se realizó con el equipo de aféresis COM.TEC. en el que se recambió 1.200 mililitros de eritrocitos totales.
Discusión: El recambio eritrocitario por aféresis aportó una notable y visible mejoría clínica y laboratorial. Por lo que en nuestra experiencia consideramos que el procedimiento fue eficiente.
Conclusiones: El recambio de eritrocitos por aféresis en el síndrome torácico agudo en crisis drepanocítica es un procedimiento que se puede utilizar en pacientes que no responden a otras terapias por su mínima alteración de la viscosidad y volumen sanguíneo en el paciente, y disminuir la concentración de hemoglobina S.
Palabras clave: Eritroféresis, síndrome torácico agudo, drepanocitosis.