bluuebunny/crossref_metadata_2025_split huggingface dataset:
An EHR-based method to structure, standardize, and automate clinical documentation tasks for pharmacists to generate extractable outcomes
Authors: Sanders Kimberly A , Wolverton Daniel , Stamopoulos Marina , Zunich Rada , Niznik Joshua , Ferreri Stefanie P 
Published: May 2023

Abstract
As the recognition of team-based care grows and pharmacists increase in patient care interventions, it is important that tools to track clinical services are easily accessible and well-integrated into workflow for all providers. We describe and discuss feasibility and implementation of data tools in an electronic health record to evaluate a pragmatic clinical pharmacy intervention focused on deprescribing in aged adults delivered at multiple clinical sites in a large academic health system. Of the data tools utilized, we were able to demonstrate clear documentation frequency of certain phrases during the intervention period for 574 patients receiving opioids and 537 patients receiving benzodiazepines. Although clinical decision support and documentation tools exist, they are underutilized or cumbersome to integrate into primary health care and strategies, such as employed, are a solution. This communication incorporates the importance of clinical pharmacy information systems in research design.
Nonmonotonic inferences: Classical conclusions in an intuitionistic modal framework
Authors: Fischer Servi Gisèle 
Published: May 2023

Abstract
We introduce a conceptual foundation for nonmonotonic reasoning which integrates an intuitionistic plurimodal logic with classical logic. The need for a multilogical system arises once we understand that to legitimately infer less than certain conclusions, we make two different kinds of assessments: an external one (what are the alternatives) and an internal one (which logic should govern the set of beliefs). We exploit this scheme to capture in novel ways basic nonmonotonic systems such as autoepistemic logic, default logic, one of the best known interpretations of negation-as-failure, as well as some conditional logics of normality. Among the aims of this paper is to explain why there are substantial overlaps between these systems and also to settle some problematic features that are of concern in logical investigations on common sense reasoning.
Probing gamma-ray burst afterglows with the Cherenkov Telescope Array
Authors: Mondal Tanima , Pramanick Suman , Resmi Lekshmi , Bose Debanjan 
Published: May 2023

ABSTRACT
Detection of delayed sub-TeV photons from gamma-ray bursts (GRBs) by MAGIC and HESS has proven the promising future of GRB afterglow studies with the Cherenkov Telescope Array (CTA), the next-generation gamma-ray observatory. With the unprecedented sensitivity of CTA, afterglow detection rates are expected to increase dramatically. In this paper, we explore the multidimensional afterglow parameter space to see the detectability of sub-TeV photons by CTA. We use a one-zone electron synchrotron and synchrotron self-Compton model to obtain the spectral energy distribution. We consider bursts going off in a medium of homogenous density. The blast wave is assumed to be radiatively inefficient and evolving adiabatically. Considering that the electron acceleration is not efficient if the acceleration time-scale exceeds the radiative cooling time-scale, we find that the sub-TeV emission is always due to the self-Compton process. We find that jets with high kinetic energy or large bulk Lorentz factor decelerating into a dense ambient medium offer better detection prospects for CTA. For relatively lower values of the downstream magnetic field, electrons are slow-cooling, and the emitted radiation is positively correlated with the magnetic field. For larger magnetic fields, the electron population enters the fast-cooling phase where the radiated flux is inversely proportional to the magnetic field. We apply our results in the context of bright TeV afterglows detected in recent years. Our results indicate that cosmological short GRBs have only moderate prospects of detection by CTA while local neutron star merger counterparts can be detected if the jet is launched towards the observer.
Gas dynamical friction as a binary formation mechanism in AGN discs
Authors: DeLaurentiis Stanislav , Epstein-Martin Marguerite , Haiman Zoltán 
Published: May 2023

ABSTRACT
In this paper, we study how gaseous dynamical friction (DF) affects the motion of fly-by stellar-mass black holes (sBHs) embedded in active galactic nucleus (AGN) discs. We perform three-body integrations of the interaction of two co-planar sBHs in nearby, initially circular orbits around the supermassive black hole. We find that DF can facilitate the formation of gravitationally bound near-Keplerian binaries in AGN discs, and we delineate the discrete ranges of impact parameters and AGN disc parameters for which such captures occur. We also report trends in the bound binaries’ eccentricity and sense of rotation (prograde or retrograde with respect to the background AGN disc) as a function of the impact parameter of the initial encounter. While based on an approximate description of gaseous friction, our results suggest that binary formation in AGN discs should be common and may produce both prograde and retrograde, as well as both circular and eccentric binaries.
JWST catches the assembly of a z ∼ 5 ultra-low-mass galaxy
Authors: Asada Yoshihisa , Sawicki Marcin , Desprez Guillaume , Abraham Roberto , Bradač Maruša , Brammer Gabriel , Harshan Anishya , Iyer Kartheik , Martis Nicholas S , Mowla Lamiya , Muzzin Adam , Noirot Gaël , Ravindranath Swara , Sarrouh Ghassan T E , Strait Victoria , Willott Chris J , Zabl Johannes 
Published: May 2023

ABSTRACT
Using CANUCS imaging we found an apparent major merger of two $z$ ∼ 5 ultra-low-mass galaxies (M⋆∼107M⊙ each) that are doubly imaged and magnified ∼12–15× by the lensing cluster MACS 0417. Both galaxies are experiencing young (∼100 Myr), synchronised bursts of star formation with log (sSFR/Gyr−1) ∼1.3–1.4, yet SFRs of just ∼0.2M⊙ yr−1. They have sub-solar (Z ∼ 0.2Z⊙) gas-phase metallicities and are connected by an even more metal-poor star-forming bridge. The galaxy that forms from the merger will have a mass of at least M⋆∼2 × 107 M⊙, at least half of it formed during the interaction-induced starburst. More than half of the ionizing photons produced by the system (before and during the merger) will have been produced during the burst. This system provides the first detailed look at a merger involving two high-$z$ ultra-low-mass galaxies of the type believed to be responsible for reionizing the Universe. It suggests that such galaxies can grow via a combination of mass obtained through major mergers, merger-triggered starbursts, and long-term in-situ star formation. If such high-$z$ mergers are common, then merger-triggered starbursts could be significant contributors to the ionizing photon budget of the Universe.
Photoionisation detection of a single Er3+ ion with sub-100-ns time resolution
Authors: Zhang Yangbo , Fan Wenda , Yang Jiliang , Guan Hao , Zhang Qi , Qin Xi , Duan Changkui , de Boo Gabriele G , Johnson Brett C , McCallum Jeffrey C , Sellars Matthew J , Rogge Sven , Yin Chunming , Du Jiangfeng 
Published: May 2023

Abstract
Efficient detection of single optical centres in solids is essential for quantum information processing, sensing and single-photon generation applications. In this work, we use radio-frequency (RF) reflectometry to electrically detect the photoionisation induced by a single Er3+ ion in Si. The high bandwidth and sensitivity of the RF reflectometry provide sub-100-ns time resolution for the photoionisation detection. With this technique, the optically excited state lifetime of a single Er3+ ion in a Si nano-transistor is measured for the first time to be $0.49 \pm 0.04\ \mu$s. Our results demonstrate an efficient approach for detecting a charge state change induced by Er excitation and relaxation. This approach could be used for fast readout of other single optical centres in solids and is attractive for large-scale integrated optical quantum systems thanks to the multi-channel RF reflectometry demonstrated with frequency multiplexing techniques.
A universal route to efficient non-linear response via Thomson scattering in linear solids
Authors: Wen Yongzheng , Giorgianni Flavio , Ilyakov Igor , Quan Baogang , Kovalev Sergey , Wang Chen , Vicario Carlo , Deinert Jan-Christoph , Xiong Xiaoyu , Bailey Joe , Chen Min , Ponomaryov Alexey , Awari Nilesh , Rovere Andrea , Sun Jingbo , Morandotti Roberto , Razzari Luca , Aeppli Gabriel , Li Junjie , Zhou Ji 
Published: May 2023

ABSTRACT
Non-linear materials are cornerstones of modern optics and electronics. Strong dependence on the intrinsic properties of particular materials, however, inhibits the at-will extension of demanding non-linear effects, especially those second-order ones, to widely adopted centrosymmetric materials (for example, silicon) and technologically important burgeoning spectral domains (for example, terahertz frequencies). Here we introduce a universal route to efficient non-linear responses enabled by exciting non-linear Thomson scattering, a fundamental process in electrodynamics that was known to occur only in relativistic electrons in metamaterial composed of linear materials. Such a mechanism modulates the trajectory of charges, either intrinsically or extrinsically provided in solids, at twice the driving frequency, allowing second-harmonic generation at terahertz frequencies on crystalline silicon with extremely large non-linear susceptibility in our proof-of-concept experiments. By offering a substantially material- and frequency-independent platform, our approach opens new possibilities in the fields of on-demand non-linear optics, terahertz sources, strong field light–solid interactions and integrated photonic circuits.
Prevalence of SARS-CoV-2 Viremia in Presymptomatic Blood Donors in the Delta and Omicron Variant Eras
Authors: Saá Paula , Fink Rebecca V , Dawar Hina , Di Germanio Clara , Montalvo Leilani , Wright David J , Krysztof David E , Kleinman Steven H , Nester Theresa , Kessler Debra A , Townsend Rebecca L , Spencer Bryan R , Kamel Hany , Vannoy Jackie , Busch Michael P , Stramer Susan L , Stone Mars , Norris Philip J ,   for the NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P)
Published: May 2023

Abstract
Presymptomatic plasma samples from 1596 donors reporting coronavirus disease 2019 infection or symptoms after blood donation were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA and anti-S and anti-N antibodies. Prior infection and vaccination both protected from developing SARS-CoV-2 RNAemia and from symptomatic infection. RNAemia rates did not differ in the Delta and Omicron variant eras.
Risk of HIV Viral Rebound in the Era of Universal Treatment in a Multi-Center Sample of Persons with HIV in Primary Care
Authors: Liu Tao , Chambers Laura C , Hansen Blake , Bazerman Lauri B , Cachay Edward R , Christopoulos Katerina , Drainoni Mari-Lynn , Gillani Fizza S , Mayer Kenneth H , Moore Richard D , Rana Aadia , Beckwith Curt G 
Published: May 2023

Abstract

Background
Antiretroviral therapy (ART) is recommended for people with HIV (PWH), irrespective of CD4 cell count, to improve their health and reduce the risk of transmission to sexual partners through long-term viral suppression. We identified risk factors for viral rebound among patients with a period of stable viral suppression to inform counseling and monitoring.

Methods
We conducted a multi-site, retrospective study of PWH with a two-year period of sustained viral suppression in the United States using the Centers for AIDS Research Network of Integrated Clinical Systems cohort. We used multivariable logistic regression to identify characteristics independently associated with any viral rebound [viral load (VL) ≥200 copies/mL] and sustained viral rebound (VL ≥200 copies/mL followed by a VL that was also ≥200 copies/mL within six months), within two years of follow-up.

Results
Among 3,496 eligible patients with a two-year period of sustained viral suppression, most (90%) continued to have viral suppression over two additional years; 10% experienced viral rebound, and 4% experienced sustained viral rebound. In multivariable analyses, Black race, current smoking, integrase strand transfer inhibitor use, and five-to-nine-year duration of ART were positively associated, and being age ≥50 years was negatively associated, with any viral rebound. Only current smoking and five-to-nine-year (vs. two-to-four-year) duration of ART were positively associated, and being age ≥60 years was negatively associated, with sustained viral rebound.

Conclusions
Most people retained in clinical care and with HIV viral suppression on ART will have persistent viral suppression. However, some patients may benefit from additional treatment adherence supports.
Suspected Germline TP53 Variants and Clonal Hematopoiesis of Indeterminate Potential: Lessons Learned From a Molecular Tumor Board
Authors: Xavier Camila B , Link Rudinei , Abreu Leonília , Bettoni Fabiana , Marson Fabiane , Galante Pedro A F , Masotti Cibele , Amano Mariane T , de Molla Vinicius , Camargo Anamaria A , Asprino Paula F , Sabbaga Jorge 
Published: May 2023

Abstract

Objective
Li-Fraumeni syndrome (LFS) is a pan-cancer predisposition syndrome caused by germline pathogenic variants in the gene TP53. The interpretation of TP53 variants in clinical scenarios outside the classic LFS criteria may be challenging. Here, we report a patient affected by 2 primary cancers at later ages, who harbored a likely pathogenic TP53 at low allele frequency detected in a blood sample.

Methods
The Molecular Tumor Board committee at our institution revisited the case of a patient who was enrolled in a research protocol for the investigation of genetic conditions associated with neuroendocrine tumors. Clinical, familial, and molecular data were reviewed. The patient received germline testing using a next generation sequencing multi-gene panel and was incidentally found to harbor a TP53 likely pathogenic variant, with 22% of variant allele fraction. Additional samples, including a second blood sample, oral swab, and saliva, were collected for DNA analysis. A new TP53 sequencing round was performed with the attempt to distinguish between a true constitutional germline variant and a somatically acquired variant due to aberrant clonal expansion of bone marrow precursors.

Results
Patient’s personal and familial history of cancer did not meet classic nor Chompret LFS criteria. Environmental risk factors for cancer were identified, such as alcohol abuse and tobacco exposure. The TP53 variant initially found in the next-generation sequencing was confirmed by Sanger sequencing in the previous DNA sample extracted from blood for the first analysis and in a second blood sample collected 6 years later. The TP53 variant was not detected in the DNA extracted from the oral swab and saliva samples.

Conclusion
Considering the low TP53 variant allele fraction in blood, absence of variant detection in oral swab and saliva samples, the lack of LFS clinical criteria, and history of exposure to environmental risk factors for cancer, the main hypothesis for this case was aberrant clonal expansion due to clonal hematopoiesis. Oncologists should interpret TP53 findings during germline testing with caution.
Screening for adverse childhood experiences among young people using drugs in Vietnam: related factors and clinical implications
Authors: Pham Thanh Luan , Nguyen Thuy Linh , Nguyen Kieu An , Ekwaru John Paul , Phan Olivier , Michel Laurent , Khuat Thi Hai Oanh 
Published: May 2023

Abstract

Background
Research evidence shows a strong association between adverse childhood experiences (ACEs) and later-life substance use. But little is known about the prevalence and impact of ACEs among young people using drugs (YPUD) in Vietnam.

Method
A cross-sectional study using respondent-driven sampling and peer recruitment methods was conducted among YPUD aged 16–24 in three cities in Vietnam. Eligible participants were screened for ACEs using the ACE-IQ, tested for HIV and hepatitis C, and assessed for sociodemographic and behavioral characteristics.

Results
Data were collected on 553 individuals whose median age was 20: 79% were male, 18.3% women and 2.7% transgender. Methamphetamine use was reported by 75.8% of participants. 85.5% reported at least one ACE and 27.5% had four ACEs or more. An ACE score of 4 or higher was associated with female and transgender, lower educational level, methamphetamine use, buying sex, depression, psychotic symptoms and expressed need for mental health support.

Conclusions
ACEs were found to be very common among YPUD in Vietnam. It is therefore strongly recommended that these young people should be provided with a comprehensive and secure assessment and care that includes not only essential harm reduction and addiction treatment needs but also addresses their mental health needs.
The effect of speech–gesture asynchrony on the neural coupling of interlocutors in interpreter-mediated communication
Authors: Duan Xu , Zhang Jie , Zhang Yi , Liang Yuan , Huang Yingying , Yan Hao 
Published: May 2023

Abstract
In everyday face-to-face communication, speakers use speech to transfer information and rely on co-occurring nonverbal cues, such as hand and facial gestures. The integration of speech and gestures facilitates both language comprehension and the skill of the theory of mind. Consecutive dialogue interpreting (DI) allows dyads of different linguistic backgrounds to communicate with each other. The interpreter interprets after the interlocutor has finished a turn, so the interlocutor watches the gesture first and hears the target language a few seconds later, resulting in speech–gesture asynchrony. In this study, we used the functional near-infrared spectroscopy hyperscanning technique to investigate the influence of speech–gesture asynchrony on different levels of communication. Twenty groups were recruited for the DI experiments. The results showed that when the interpreter performed consecutive interpreting, the time-lagged neural coupling at the temporoparietal junction decreased compared to simultaneous interpreting. It suggests that speech–gesture asynchrony significantly weakened the ability of interlocutors to understand each other’s mental state, and the decreased neural coupling was significantly correlated with the interpreter’s interpretation skill. In addition, the time-aligned neural coupling at the left inferior frontal gyrus increased, which suggests that, as compensation, the interlocutor’s verbal working memory increases in line with the communication process.
Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis
Authors: Falkai Peter , Rossner Moritz J , Raabe Florian J , Wagner Elias , Keeser Daniel , Maurus Isabel , Roell Lukas , Chang Emily , Seitz-Holland Johanna , Schulze Thomas G , Schmitt Andrea 
Published: May 2023

Abstract

Background and Hypothesis
Cognitive impairment is a hallmark of schizophrenia, but no effective treatment is available to date. The underlying pathophysiology includes disconnectivity between hippocampal and prefrontal brain regions. Supporting evidence comes from diffusion-weighted imaging studies that suggest abnormal organization of frontotemporal white matter pathways in schizophrenia.

Study Design
Here, we hypothesize that in schizophrenia, deficient maturation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes substantially contributes to abnormal frontotemporal macro- and micro-connectivity and subsequent cognitive deficits.

Study Results
Our postmortem studies indicate a reduced oligodendrocyte number in the cornu ammonis 4 (CA4) subregion of the hippocampus, and others have reported the same histopathological finding in the dorsolateral prefrontal cortex. Our series of studies on aerobic exercise training showed a volume increase in the hippocampus, specifically in the CA4 region, and improved cognition in individuals with schizophrenia. The cognitive effects were subsequently confirmed by meta-analyses. Cell-specific schizophrenia polygenic risk scores showed that exercise-induced CA4 volume increase significantly correlates with OPCs. From animal models, it is evident that early life stress and oligodendrocyte-related gene variants lead to schizophrenia-related behavior, cognitive deficits, impaired oligodendrocyte maturation, and reduced myelin thickness.

Conclusions
Based on these findings, we propose that pro-myelinating drugs (e.g., the histamine blocker clemastine) combined with aerobic exercise training may foster the regeneration of myelin plasticity as a basis for restoring frontotemporal connectivity and cognition in schizophrenia.
Called to Work: Developing a Framework for Understanding Spiritual Orientations Towards Work
Authors: Kalinowski Brenton , Daniels Denise , Schneider Rachel C , Howard Ecklund Elaine 
Published: May 2023

Abstract
This study examines how individuals understand spiritual calling to work. We draw on theoretic insights from Max Weber and Karl Marx to analyze 186 in-depth interviews with religious individuals in the United States. We argue that these classical frameworks can help us to better understand contemporary religious interpretations of calling in relationship to work. We propose a framework for categorizing ways of viewing work as a calling that consists of intrinsic/extrinsic meanings in work and goals that are proximal/distal to the workplace. While focusing primarily on Christian respondents, we note that some respondents from Jewish and Muslim traditions did not resonate directly with the term “calling” but had alternate ways of viewing their work that closely aligned with Christian conceptions of calling. We ultimately argue for the theoretical benefit of a Weberian conception of calling for contemporary understandings of how meaning is attached to work, but also highlight that seeing work as calling may be a double-edged sword because doing so may provide benefits to workers while simultaneously obscuring their own oppression.
The ClaDS rate-heterogeneous birth–death prior for full phylogenetic inference in BEAST2
Authors: Barido-Sottani Joëlle , Morlon Hélène 
Published: May 2023

Abstract
Bayesian phylogenetic inference requires a tree prior, which models the underlying diversification process that gives rise to the phylogeny. Existing birth–death diversification models include a wide range of features, for instance, lineage-specific variations in speciation and extinction (SSE) rates. While across-lineage variation in SSE rates is widespread in empirical datasets, few heterogeneous rate models have been implemented as tree priors for Bayesian phylogenetic inference. As a consequence, rate heterogeneity is typically ignored when reconstructing phylogenies, and rate heterogeneity is usually investigated on fixed trees. In this paper, we present a new BEAST2 package implementing the cladogenetic diversification rate shift (ClaDS) model as a tree prior. ClaDS is a birth–death diversification model designed to capture small progressive variations in birth and death rates along a phylogeny. Unlike previous implementations of ClaDS, which were designed to be used with fixed, user-chosen phylogenies, our package is implemented in the BEAST2 framework and thus allows full phylogenetic inference, where the phylogeny and model parameters are co-estimated from a molecular alignment. Our package provides all necessary components of the inference, including a new tree object and operators to propose moves to the Monte-Carlo Markov chain. It also includes a graphical interface through BEAUti. We validate our implementation of the package by comparing the produced distributions to simulated data and show an empirical example of the full inference, using a dataset of cetaceans.