bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on Knowledge Graph Technology with Unbalanced Samples
Authors: Chen Hao , Bai Yang , Wei Miaomiao 
Published: May 2023

Abstract
The application of the existing knowledge graph is widely concentrated in the civil fields with sufficient sample size and uniform distribution, especially in the Internet, finance and other fields. Due to the particularity of its application background in the military field, there is a general lack of sample size, which greatly limits the support ability of knowledge atlas technology for military intelligent applications. Therefore, how to solve the problem of automatic knowledge extraction of multimodal data under the condition of unbalanced samples is the key core problem that affects the application effect of knowledge perception technology in the military field. This topic focuses on the characteristics of small batch, multi batch, imbalance and diversity of data in the field of military operations, introduces the self-monitoring method based on deep learning, solves the problem of low accuracy of automatic knowledge extraction of unstructured data, solves the dependence of traditional intelligent extraction algorithm on sample size, carries out research on automatic construction technology of knowledge atlas, and constructs equipment type spectrum library.
Research on Multi-Objective Optimization to the Shape of Air Cushion Surge Tank
Authors: Zhang Tianyu , Huang Yan , Zhou Jianzhong , Zhang Yongchuan , Cui Zilong 
Published: May 2023

Abstract
This paper aims to research on multi-objective optimization to the shape of air cushion surge tank (ACST) in hydropower station. Firstly, a novel nonlinear mathematical model of hydropower station with ACST is established. Then, the analysis of the structure parameter of ACST on hydropower station during transient process is carried out. Furthermore, a multi-objective optimization and decision-making method is applied to determine the shape of ACST. Finally, it is carried out that the comparison analysis by numerical simulation between the optimal parameter and initial parameters of ACST under the checking condition. The results indicate that the impedance hole area, initial gas pressure and cross-sectional area has influence on the transient process index of hydropower station to a certain extent, so they are selected as optimization variables. The hydropower station shows superior dynamic quality under the optimized shape of ACST both in the design condition and in the checking condition. Specifically, the maximum water pressure at the end of volute is reduced by 5.84m and 5.19m respectively, the maximum pressure of air chamber decreases by 2.18m and 1.76m separately, and the extreme water level of ACST goes down by 3.82m and 3.81m solely under design condition and checking condition.
Optimal Choices of Reconstruction Parameters United Improved C-C Algorithm and Improved G-P Algorithm
Authors: Wei Lai , Cao Hui , Wang Longde 
Published: May 2023

Abstract
For the phase space reconstruction of chaotic time series, the precise selection of delay and embedding dimension is indispensable. Therefore, this paper makes an in-depth study on the selection of reconstruction parameters, and puts forward some suggestions for improving the theoretical defects of the original C-C algorithm and G-P algorithm. The modified C-C algorithm optimizes the intermediate determination parameters of delay time and embedded window of the original algorithm, and makes the selection of delay time and embedded window more accurate. The improved G-P algorithm optimizes the range of neighborhood radius and the selection of scale-free interval, and improves the calculation accuracy of embedding dimension. On the theoretical basis, Lorenz sequence and Rossler sequence are used to verify, and the simulation results can be obtained. The improved algorithm can select parameters more accurately. Finally, the parameters obtained by the two improved algorithms are compared, and it is considered that the phase space reconstruction can be better by using the improved C-C algorithm to solve the delay and the improved G-P algorithm to solve the embedding dimension.
Proportional Counter array (PCa) — a new concept and its realization
Authors: Tian Xiangqi , Zhou Yi , Shao Ming , Liu Jianbei , Zhang Zhiyong , Shang Lunlin , Wu Zhexu , Wang Xu , He Siqi 
Published: May 2023

Abstract
In this study, we introduce a new structure of micro-pattern gaseous detector, named
proportional counter array (PCa). The standard Printed Circuit Board (PCB) process, which is
cost-effective and easy to scale up, is used to manufacture the PCa prototypes. Both simulation
and experimental studies were performed to characterise the prototypes, which demonstrated
promising performance in terms of gas gain, rate capability, and ion backflow suppression. The
prospects of the PCa technology are also discussed.
Therapeutic hyperthermia regulates complement C3 activation and suppresses tumor development through HSPA5/NFκB/CD55 pathway in nasopharyngeal carcinoma
Authors: Chen Chengcong , Ren Anbang , Yi Qi , Cai Jiazuo , Khan Muhammad , Lin Yunen , Huang Zhong , Lin Jie , Zhang Jian , Liu Wei , Xu Anan , Tian Yunhong , Yuan YaWei , Zheng Ronghui 
Published: May 2023

Abstract
Nasopharyngeal carcinoma (NPC) is endemic in Southern China and Southeast Asia. Hyperthermia is widely used in combination with chemotherapy and radiotherapy to enhance therapeutic efficacy in NPC treatment, but the underlying anti-tumor mechanisms of hyperthermia remain unclear. Complement C3 has been reported to participate in the activation of immune system in the tumor microenvironment, leading to tumor growth inhibition. In this study, we aimed to explore the effect and mechanisms of hyperthermia and investigate the functional role of complement C3 in NPC hyperthermia therapy (HT). The serum levels of complement C3 before and after hyperthermia therapy in patients with NPC were analyzed. NPC cell lines SUNE1 and HONE1 were used for in vitro experiment to evaluate the function of complement C3 and HT on cell proliferation and apoptosis. SUNE1 xenograft mouse model was established and tumor-bearing mice were treated in water bath at a constant temperature of 43°C. Tumor samples were collected at different time points to verify the expression of complement C3 by immunohistochemical staining and western blot. The differential expressed genes after hyperthermia were analyzed by using RNA sequencing. We found that complement could enhance hyperthermia effect on suppressing proliferation and promoting apoptosis of tumor cells in NPC. Hyperthermia decreased the mRNA expression of complement C3 in tumor cells, but promoted the aggregation and activation circulating C3 in NPC tumor tissue. By using in vitro hyperthermia-treated NPC cell lines and SUNE1 xenograft tumor-bearing mice, we found that the expression of heat shock protein 5 (HSPA5) was significantly upregulated. Knockdown of HSPA5 abrogated the anti-tumor effect of hyperthermia. Moreover, we demonstrated that hyperthermia downregulated CD55 expression via HSPA5/NFκB (P65) signaling and activated complement cascade. Our findings suggest that therapeutic hyperthermia regulates complement C3 activation and suppresses tumor development via HSPA5/NFκB/CD55 pathway in NPC.
Impact of Biotin Supplementation on Human Chorionic Gonadotropin Immunoassays Utilizing Biotin-Streptavidin Binding Methods in Urine
Authors: Goodrum Jenna M , Nair Vinod S , Moore Chad , Crouch Andre K , Eichner Daniel , Miller Geoffrey D 
Published: May 2023

Abstract

Background
Human chorionic gonadotropin (hCG) detection is indicative of pregnancy and can be indicative of some forms of cancerous tumors. The hCG drug itself, however, is a performance enhancing substance used by male athletes to increase testosterone production. Antidoping testing for hCG is conducted in urine, often on immunoanalyzer platforms, many of which utilize biotin-streptavidin dependent immunoassays in which the presence of biotin in samples is a known confounding factor. While biotin interference in serum has been well-studied, the extent of biotin interference in urine has not.

Methods
Ten active male individuals underwent a 2-week hCG administration protocol concurrent with supplementation with biotin (20 mg/day) or placebo. Urine and serum samples were collected throughout the study and analyzed for hCG and biotin concentrations.

Results
Urinary biotin levels in the hCG + biotin group increased 500-fold over baseline and 29-fold over corresponding serum biotin levels after biotin supplementation. When using a biotin-dependent immunoassay, the hCG + placebo group produced hCG-positive results (hCG ≥ 5 mIU/mL) in 71% of urine samples, while the hCG + biotin group produced positive results in only 19% of samples. Both groups had elevated hCG values in serum measurements by a biotin-dependent immunoassay and in urine when using a biotin-independent immunoassay. Urinary hCG measurements and biotin levels from the hCG + biotin group showed a negative correlation (Spearman r = −0.46, P &lt; 0.0001) when measured using a biotin-dependent immunoassay.

Conclusions
Biotin supplementation can severely suppress urinary hCG values in assays utilizing biotin-streptavidin binding methods and therefore these types of assays are not recommended for use in urine samples containing high levels of biotin.
Clinicaltrials.gov Registration Number: NCT05450900
Stroke disease–specific quality of life trajectories and their associations with caregivers’ anxiety, depression, and burden in stroke population: a longitudinal, multicentre study
Authors: Bartoli Davide , Brugnera Agostino , Grego Andrea , Alvaro Rosaria , Vellone Ercole , Pucciarelli Gianluca 
Published: May 2023

Abstract

Aims
The aims of this study were to: (i) test if there are clusters of stroke survivors who experience distinct trajectories of quality of life (QOL) from hospital rehabilitation discharge to 12-month follow-up; (ii) test if any sociodemographic or clinical variables predict this class membership; and (iii) examine the associations between the clusters of stroke survivors’ and their caregivers’ trajectories of anxiety, depression, and burden over time.

Methods and results
A total of 415 stroke survivors and their caregivers were recruited in Italy for this 1-year, longitudinal, multicentre prospective study, filling out a survey at five time points. We found two distinct trajectories of change in stroke survivors’ psychological QOL (i.e. Memory, Communication, Emotion, and Participation). The first trajectory (86% of the survivors) included those who started with greater levels of QOL and improved slightly to markedly in all psychological domains, while the second trajectory (14% of the survivors) comprised those who started with lower overall levels of psychological QOL and experienced a worsening or no changes at all in these dimensions up to 12-month follow-up. Very few clinical and sociodemographic variables at baseline predicted class membership. Finally, caregivers of those patients who experienced no change or a worsening in psychological QOL reported greater distress and burden over time.

Conclusion
Our results highlight the need for more tailored interventions to improve patients’ psychological QOL and consequently their caregivers’ well-being. This requires a shift from a stroke survivor–centred approach to a stroke survivor– and caregiver-centred one.
Genetic characteristics of platinum-sensitive ovarian clear cell carcinoma
Authors: Saito Ryosuke , Kuroda Takafumi , Yoshida Hiroshi , Sudo Kazuki , Saito Motoaki , Tanabe Hiroshi , Takano Hirokuni , Yamada Kyosuke , Kiyokawa Takako , Yonemori Kan , Kato Tomoyasu , Okamoto Aikou , Kohno Takashi 
Published: May 2023

AbstractObjectiveMost ovarian clear cell carcinomas are resistant to platinum-based chemotherapy, while a small subset shows a positive response. The aim of this study was to clarify the clinical, pathological and genetic characteristics of platinum-sensitive ovarian clear cell carcinomas.MethodsThe study included 53 patients with stage III–IV ovarian clear cell carcinoma who had residual tumours after primary surgery and received platinum-based therapy between 2009 and 2018. A retrospective examination of platinum sensitivity was performed using the criterion of ≥6 months from the last day of first-line platinum therapy until recurrence/progression. Cases determined to be platinum-sensitive were subjected to immunohistochemical staining, genomic analyses using target sequencing (i.e. NCC Oncopanel) and homologous recombination deficiency (myChoice® HRD Plus) assays.ResultsOf the 53 stage III–IV ovarian clear cell carcinoma cases, 11 (21%) were platinum-sensitive. These cases showed better progression-free and overall survival than platinum-resistant cases (hazard ratio = 0.16, P &lt; 0.001). Among the seven sensitive cases whose tumour tissues were available for molecular profiling, five were pure ovarian clear cell carcinoma based on pathological and genetic features, whereas the remaining two cases were re-diagnosed as high-grade serous ovarian carcinoma. The pure ovarian clear cell carcinomas lacked BRCA1 and BRCA2 mutations, consistent with the absence of the homologous recombination deficiency phenotype, whereas two cases (40%) had ATM mutations. By contrast, the two high-grade serous ovarian carcinoma cases had BRCA1 or BRCA2 mutations associated with the homologous recombination deficiency phenotype.ConclusionThe subset of platinum-sensitive ovarian clear cell carcinomas includes a majority with pure ovarian clear cell carcinoma features that lack the homologous recombination deficiency phenotype.
Protocol for the systematic review and network meta-analysis of open versus video-assisted and robotic-assisted thymectomy for the treatment of thymic neoplasms
Authors: Huo Bright , Lee Yung , Kontouli Katerina-Maria , Patel Pooja , Yang Kevin , Jong Audrey , Coyle Kassandra , French Daniel G , Wallace Alison M , Plourde Madelaine 
Published: May 2023

Abstract
The surgical management of thymic neoplasms includes open and minimally invasive approaches. Previous studies have compared these techniques, but application in practice remains varied. This systematic review and network meta-analysis (NMA) will adhere to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) checklist. MEDLINE, Embase, Cochrane Centrale and Scopus will be searched from inception to perform a systematic review, NMA and evidence appraisal using the Grading of Recommendations Assessment, Development and Evaluations and the Confidence in Network Meta-Analysis methodologies. Randomized controlled trials and cohort studies will be included. Full texts of any citation will be included if they assessed a minimum of two arms of any type of thymectomy technique, including open, video-assisted thoracoscopic surgery, or robotic-assisted thoracoscopic surgery thymectomy, for the treatment of thymic neoplasms such as thymoma, thymic carcinoma or thymic neuroendocrine tumors with or without myasthenia gravis. Studies assessing operative thymectomy techniques for benign disease will be excluded. Short- and long-term perioperative safety and oncologic outcomes will be compared between open versus video-assisted versus robotic-assisted thymectomy for the surgical management of thymic neoplasms. The Risk of Bias In Non-Randomized Studies—of Interventions tool will be used to assess the risk of bias in nonrandomized studies. We will conduct a frequentist fixed- and random-effects NMA using the graph theory approach for each outcome. Summary of odds ratios will be estimated for all dichotomous outcomes with their 95% confidence interval.
Star-forming environments in smoothed particle magnetohydrodynamics simulations I: clump extraction and properties
Authors: Wurster James , Rowan Connar 
Published: May 2023

ABSTRACT
What is the nature of a star-forming clump? Observations reveal these to be chaotic environments being modified and influenced by many physical processes. However, numerical simulations often define these initial star-forming clumps to be idealized objects. In this paper, we define and analyse 109 star-forming clumps extracted from our previous low-mass star cluster simulations. To define a clump, we identify all the gas in a simulation that ever becomes bound to or accreted onto a star, then follow the gas backwards in time until it decreases to a critical density. This gas and its neighbouring gas are defined as our star-forming clump. Our clumps span a mass range of 0.15 ≲ M/M⊙ ≲ 10.2, while the density range within each clump spans 2–4 orders of magnitude. The gas density distribution is not smooth, indicating that it is highly structured. The clumps are turbulent, with no coherent rotation. Independent of the initial magnetic field strength of the parent cloud, all clumps yield a similar range of field strengths. The clump magnetic field is ordered but not reflective of the initial field geometry of the parent cloud. In general, most clump properties have a slight trend with clump mass but are independent of (or only very weakly dependent on) the properties of the parent cloud. We conclude that stars are born from a wide variety of environments and there is not a single universal star-forming clump.
Scattering transparency of clouds in exoplanet transit spectra
Authors: Jaiswal Bhavesh , Robinson Tyler D 
Published: May 2023

ABSTRACT
The presence of aerosols in an exoplanet atmosphere can veil the underlying material and can lead to a flat transmission spectrum during primary transit observations. In this work, we explore forward scattering effects from supermicron-sized aerosol particles present in the atmosphere of a transiting exoplanet. We find that the impacts of forward scattering from larger aerosols can significantly impact exoplanet transits and the strength of these effects can be dependent on wavelength. In certain cloud configurations, the forward-scattered light can effectively pass through the clouds unhindered, thus rendering the clouds transparent. The dependence of the aerosol scattering properties on wavelength can then lead to a positive slope in the transit spectrum. These slopes are characteristically different from both Rayleigh and aerosol absorption slopes. As examples, we demonstrate scattering effects for both a rocky world and a hot Jupiter. In these models, the predicted spectral slopes due to forward-scattering effects can manifest in the transit spectrum at the level of ∼10–∼100 s of parts per million and, hence, could be observable with NASA’s JWST.
The Underlying Unity of Hope and Trust
Authors: Ratcliffe Matthew 
Published: May 2023

Abstract
This paper addresses the relationships between hope and trust. I suggest that different kinds of hope and trust relate to one another in different ways, which I conceive of in dynamic terms. I propose that the movement of hope and trust has a unifying context: the changing structure of a human life and its dependence on other people. I further argue that the most fundamental forms of hope and trust are inextricable. Together, they comprise a diffuse way of anticipating things in general, which could equally be described in terms of “faith.” This sustains a life structure upon which more specific forms of hope and trust depend.
The Primacy of Hope for Human Flourishing
Authors: Jeffrey Anne , Mehari Krista 
Published: May 2023

Abstract
In this paper we argue that the eudaimonist virtue of hope holds pride of place in development of psychological traits that promote human flourishing. The argument is part theoretical and part empirical. On the theoretical side, hope, the virtue, is the disposition to envision future good possibilities for oneself and one’s community and to move towards those possibilities. This renders hope necessary for any agent’s self-conscious pursuit of the goods that constitute flourishing, and also for the development of other virtues. On the empirical side, we draw on evidence from psychology to argue that early in development, humans need relationships of trust with caregivers to develop the future orientation and features of agency constitutive of the virtue of hope. Thus the virtue of hope generally needs to be fostered, in part, through trusting relationships for humans to flourish.
Alterations of ribosomal RNA pseudouridylation in human breast cancer
Authors: Barozzi Chiara , Zacchini Federico , Corradini Angelo Gianluca , Morara Monica , Serra Margherita , De Sanctis Veronica , Bertorelli Roberto , Dassi Erik , Montanaro Lorenzo 
Published: May 2023

Abstract
RNA modifications are key regulatory factors for several biological and pathological processes. They are abundantly represented on ribosomal RNA (rRNA), where they contribute to regulate ribosomal function in mRNA translation. Altered RNA modification pathways have been linked to tumorigenesis as well as to other human diseases. In this study we quantitatively evaluated the site-specific pseudouridylation pattern in rRNA in breast cancer samples exploiting the RBS-Seq technique involving RNA bisulfite treatment coupled with a new NGS approach. We found a wide variability among patients at different sites. The most dysregulated positions in tumors turned out to be hypermodified with respect to a reference RNA. As for 2′O-methylation level of rRNA modification, we detected variable and stable pseudouridine sites, with the most stable sites being the most evolutionary conserved. We also observed that pseudouridylation levels at specific sites are related to some clinical and bio-pathological tumor features and they are able to distinguish different patient clusters. This study is the first example of the contribution that newly available high-throughput approaches for site specific pseudouridine detection can provide to the understanding of the intrinsic ribosomal changes occurring in human tumors.
A case of malignant mesothelioma in a young patient with childhood leukaemia who had received total body irradiation
Authors: Hayat Redwan , Ahmed Saad , Badiger Rekha , Lee Shi Han , Peryt Adam , Gilligan David , Khalid Zubair 
Published: May 2023

Abstract
This case report explores a 34-year-old male diagnosed with mesothelioma who had no known risk factors. The patient initially was treated for empyema with antibiotics but later represented to hospital with worsening symptoms. He underwent a surgical Video-assisted thoracoscopic surgery procedure and lung biopsy, which revealed a diagnosis of mesothelioma. The young age of the patient as well as absence of significant risk factors for mesothelioma made the diagnosis unexpected. The patient had total body irradiation (TBI) therapy for leukaemia as a child, which increases the risk of developing cancer. However, there are limited studies exploring the risk of pleural mesothelioma post-TBI. Young patients who represent to hospital, with limited response to initial treatment, and suspicious radiological features should be considered for lung biopsy to reduce the risk of a missed diagnosis. Patients with a background of TBI should also be considered for follow-up to monitor for any subsequent malignancy.
Unusual case of adult-onset cutaneous lupus erythematosus mimicking early mycosis fungoides
Authors: Ahmed Hanof , Petkar Mahir , Wafi Omar , Abu Shaikha Samya 
Published: May 2023

Abstract
Discoid lupus erythematosus (DLE) is a chronic variant of cutaneous lupus erythematous developing on sun-exposed areas in multi-morphic forms making diagnosis challenging. Clinical suspicion and prompt treatment are necessary to avoid permanent disfigurement, progression to systemic involvement and poor quality of life. We report a case of delayed DLE diagnosis in a 45-year-old man who presented with a new skin lesion mimicking the early stages of mycosis fungoides that prompted further investigation. Histopathological examination confirmed DLE and appropriate treatment was initiated. However, the atypical clinical presentation led to disseminated DLE and refractory disease control, resulting in scarring and cosmetic disfigurement.