bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Consideration of the Skin Effect
Authors: Maslov Sergey , Maslov Iurii , Maslov Dmitry 
Published: April 2023

Abstract
The article proposes an approach to solving the normal skin effect problem based on integral equations derived di-rectly from Ampère's circuital law, Faraday's law of induction and Kirchhoff's circuit laws, in contrast to modern solu-tions based on Maxwell's equations of electrodynamics in differential form. It is shown that the skin effect is mainly due to the electromotive force of the wire self-induction, which depends on the distance to the surface, and the influence of eddy currents is either very small or absent. New equations, their solutions and formulas for the total current and im-pedance are proposed for various technically significant cases immediately taking into account the inductance of the external space and in two versions: taking into account only the self-induction of the conductor; taking into account both self-induction and eddy currents. On the example of a solid cylinder, it is shown that, in accordance with the for-mulas of the existing approach itself, the current density on the surface of the wire does not increase with increasing frequency, as it is stated in words. It is shown that, in fact, the solutions of the existing concept are based not on eddy currents, but on the uneven distribution of elementary self-induction currents over depth and are completely equivalent to the variant of the presented solutions, taking into account only self-induction. Power balances were obtained without the introduction of a frequency-dependent active resistance to alternating current in two versions: based on the total current, voltage and average electromotive force of induction; based on the integration of the balance of specific powers over the entire volume of the wire. The physical meaning of the visual increase of the active resistance with increasing frequency is revealed, but certainly not on the basis of a decrease in the effective cross section of the wire. Based on the symmetry of the distribution of eddy currents, the assumption is made that they are absent in galvanically closed wires, but present in open wires such as antennas. An experiment was carried out with a negative result on the detection of the alleged thermal separation in the wire, an explanation for this was proposed.
Robust mean-variance efficient strategies of DC pension plans with ambiguity under stochastic interest rate and stochastic volatility
Authors: Chang Hao , Zhao Leilei , Chen Xingjiang 
Published: April 2023

Abstract

This paper studies a robust optimal investment problem with an ambiguity-averse manager (AAM) for a defined contribution (DC) plan with multiple risks under the mean-variance criterion. In the pension accumulation stage, the interest rate, the volatility and the salary level are considered to be stochastic. The financial market consists of a risk-free asset, a risky asset and a rolling bond. We assume that the term structure of interest rates is driven by an affine interest rate model, while the stock price and the salary level are modeled by the stochastic volatility model with stochastic interest rate. The goal of an AAM is to find a robust optimal strategy to maximize the expectation of terminal wealth and minimize the variance of terminal wealth in the worst-case scenario. By applying the Lagrange dual theory and the robust optimal control approach, we obtain closed-form expressions of the robust efficient strategy and the efficient frontier, and subsequently some special cases are derived. Finally, a numerical example is given to illustrate the results obtained.
AMS classifications: 60H30, 91G10, 93E20.
The relationship between harsh parenting and depression in adolescents: The chain mediation effect of rumination and bullying
Authors: Wang Jirui , Li Mengge , Sun Wenyan , Ma Peng , Gong Huoliang 
Published: April 2023

Abstract
Based on the family system theory, this study provides a comprehensive exploration of the mechanisms through which harsh parenting, rumination, and bullying contribute to the development of adolescent depression. A total of 5047 adolescents were investigated with the Harsh Parenting Scale, Rumination Scale, Olweus Bullying Questionnaire and Beck Depression Inventory. The results showed that harsh parenting had a positive effect on adolescent depression. Rumination plays a mediating role between harsh parenting and adolescent depression. Bullying played a mediating role between harsh parenting and adolescent depression. Rumination and bullying play a chain mediating role between harsh parenting and adolescent depression. The findings of this study demonstrate that harsh parenting can impact adolescent depression by way of rumination and bullying. This study enhances the understanding of the mechanisms through which harsh parenting influences adolescent depression and provides novel insights for interventions aimed at alleviating depression in this population.
Peptidomic Analysis and Antimicrobial Activity of Serum Peptide from
Hevea brasiliensis Clone BPM24
Authors: Havanapan Phattara-orn , Ieamkheng Supaporn , Phungthanom Nuanwan , Bourchookarn Walairat , Bourchookarn Apichai , Krittanai Chartchai 
Published: April 2023

Background::
Hevea brasiliensis is severely affected by the fungal disease caused by
Phytophthora spp. Significant loss of rubber yield is widespread and extensive use of chemical
fungicides has resulted in health and environmental problems.

Objective::
This work aims to extract and identify the latex serum peptides from a disease tolerant
clone of H. brasiliensis, and study the inhibitory efficacy against pathogenic bacteria and fungi.

Methods::
Serum peptides were extracted from H. brasiliensis BPM24 using mixed lysis solution.
Low molecular weight peptides were screened and fractionated by solid-phase extraction and then
identified by tandem mass spectrometry. Total and fractionated serum peptides were assayed for
bacterial and fungal inhibition using broth microdilution and poisoned food methods. An inhibitory
control study in the greenhouse was also performed using susceptible clones for pre and postinfection
with Phytophthora spp.

Results::
Forty-three serum peptide sequences were successfully identified. Thirty-four peptides
matched with the proteins associated with plant defense response signaling, host resistance, and
adverse environmental factors. The inhibitory study of total serum peptides demonstrated antibacterial
and anti-fungal properties. The greenhouse study exhibited disease inhibitory efficacy of
60% for the treatment of Phytophthora spp. in post-infected plants and 80% for pre-treated samples.

Conclusion::
Latex serum peptides from disease tolerant H. brasiliensis revealed several proteins and
peptides associated with plant defense and disease resistance. The peptides play a vital role for
defense against bacteria and fungi pathogens, including Phytophthora spp. Enhanced disease
protection can be obtained when the extracted peptides were applied to the susceptible plants before
exposure to the fungi. These findings provided an insight and may pave the way for the development
of biocontrol peptides from natural resources.
Isopeptide Bond Bundling Superhelix for Designing Antivirals against
Enveloped Viruses with Class I Fusion Proteins: A Review
Authors: Na Heiya , Liang Guodong , Lai Wenqing 
Published: April 2023

Abstract:
Viral infection has become one of the worst human lethal diseases. In recent years,
major gains have been made in the research of peptide-based antiviral agents on account of the
mechanism of viral membrane fusion, among which the peptide Enfuvirtide has been listed for the
treatment of AIDS. This paper reviewed a new way to design peptide-based antiviral agents by
"bundling" superhelix with isopeptide bonds to construct the active advanced structure. It can
solve the problem that peptide precursor compounds derived from the natural sequence of viral
envelope protein tend to aggregate and precipitate under physiological conditions and low activity
and endow the peptide agents with the feature of thermal stability, protease stability and in vitro
metabolic stability. This approach is also providing a new way of thinking for the research and
development of broad-spectrum peptide-based antiviral agents.
Exploring the Effects of Chirality of 5-methyl-5-[4-(4-oxo-3H-quinazolin-2- yl)phenyl]imidazolidine-2,4-dione and its Derivatives on the Oncological Target Tankyrase 2. Atomistic Insights
Authors: Peters Xylia Q. , Poonan Preantha , Salifu Elliasu. Y. , Alahmdi Mohamed I. , Abo-Dya Nader E. , Soliman Mahmoud E. S. 
Published: April 2023

Background:
Tankyrases (TNKS) are homomultimers existing in two forms, viz.
TNKS1 and TNKS2. TNKS2 plays a pivotal role in carcinogenesis by activating the Wnt//β-
catenin pathway. TNKS2 has been identified as a suitable target in oncology due to its crucial role
in mediating tumour progression. The discovery of 5-methyl-5-[4-(4-oxo-3H-quinazolin-2-yl)
phenyl]imidazolidine-2,4-dione, a hydantoin phenylquinazolinone derivative which exists as a
racemic mixture and in its pure enantiomer forms, has reportedly exhibited inhibitory potency
towards TNKS2. However, the molecular events surrounding its chirality towards TNKS2 remain
unresolved.

Methods:
Herein, we employed in silico methods such as molecular dynamics simulation coupled
with binding free energy estimations to explore the mechanistic activity of the racemic inhibitor
and its enantiomer forms on TNKS2 at a molecular level.

Results:
Favourable binding free energies were noted for all three ligands propelled by electrostatic
and van der Waals forces. The positive enantiomer demonstrated the highest total binding free
energy (-38.15 kcal/mol), exhibiting a more potent binding affinity to TNKS2. Amino acids
PHE1035, ALA1038, and HIS1048; PHE1035, HIS1048 and ILE1039; and TYR1060, SER1033
and ILE1059 were identified as key drivers of TNKS2 inhibition for all three inhibitors, characterized
by the contribution of highest residual energies and the formation of crucial high-affinity
interactions with the bound inhibitors. Further assessment of chirality by the inhibitors revealed a
stabilizing effect of the complex systems of all three inhibitors on the TNKS2 structure. Concerning
flexibility and mobility, the racemic inhibitor and negative enantiomer revealed a more rigid
structure when bound to TNKS2, which could potentiate biological activity interference. The positive
enantiomer, however, displayed much more elasticity and flexibility when bound to TNKS2.

Conclusion:
Overall, 5-methyl-5-[4-(4-oxo-3H-quinazolin-2-yl)phenyl]imidazolidine-2,4-dione
and its derivatives showed their inhibitory prowess when bound to the TNKS2 target via in silico
assessment. Thus, results from this study offer insight into chirality and the possibility of adjustments
of the enantiomer ratio to promote greater inhibitory results. These results could also offer
insight into lead optimization to enhance inhibitory effects.
Plants of the Genus Mahonia as a Potential Traditional Chinese Medicine for the Prevention and Treatment of Alzheimer's Disease
Authors: Huang Shengfeng , Huang Yang , Yang Shuo , Shao Huikai , Chen Xiyu , Liu Qiwen 
Published: April 2023

Abstract:
Alzheimer’s disease (AD), a prevalent multiple neurodegenerative disease, has gained attention, particularly in the aging population. However, presently available therapies merely focus on alleviating the symptoms of AD and fail to slow disease progression significantly. Traditional Chinese medicine (TCM) has been used to ameliorate symptoms or interfere with the pathogenesis of aging-associated diseases for many years based on disease-modifying in multiple pathological roles with multi-targets, multi-systems and multi-aspects. Mahonia species as a TCM present potential for anti-inflammatory activity, antioxidant activity, anti-acetylcholinesterase activity, and anti-amyloid-beta activity that was briefly discussed in this review. They are regarded as promising drug candidates for AD therapy. The findings in this review support the use of Mahonia species as an alternative therapy source for treating AD.
A Comprehensive Review on the Benzimidazole Scaffold as a Potential
Nucleus for Anticancer Activity
Authors: Pathak Shilpi , Sharma Richa 
Published: April 2023

Abstract:
It is common knowledge that cancer is the world's biggest cause of mortality. This has led
to the ongoing introduction and validation of new cancer therapy outcomes. Benzimidazole derivatives
control DNA stability and cell cycle advancement. A heterocyclic nucleus is structurally more
favourable for a direct DNA connection and, thus, for the management of the DNA replication process.
This review seeks to explore the usefulness of such drugs in the future facets of cancer prognosis
and treatment in addition to discussing the role of benzimidazole in cancer therapy. Benzimidazole derivatives
have been reported as a pertinent therapeutic strategy to modify cancer progression and malignancy
in the data from 2013 to 2022. Here, we emphasize these features in several cancer types and
cell lines using in vitro and in vivo methods.
Isocyanide-based Multicomponent Reactions (IMCRs) in Water or
Aqueous Biphasic Systems
Authors: Divyavani Chitteti , Padmaja Pannala , Reddy Pedavenkatagari Narayana 
Published: April 2023

Background:
Isocyanide is an intriguing one-carbon synthon that is frequently employed in a variety of carbon-carbon and carbon-heteroatom bond-forming reactions. Isocyanide-based multicomponent reactions (IMCRs) are effective synthetic tools in organic synthesis for the prepa-ration of complex heterocyclic molecules. The IMCRs in water have become an attractive research direction, enabling simultaneous growth of both IMCRs and green solvents towards ideal organic synthesis.

Objective:
The goal of this review is to provide a general overview of IMCRs in water or biphasic aqueous systems for accessing various organic molecules, as well as an examination of their bene-fits and mechanistic insights.

Conclusion:
High atom economies, mild reaction conditions, high yields, and catalyst-free process-es are crucial features of these IMCRs in water or biphasic aqueous systems.
Miscellaneous Naturally Derived Anticancer Agents
Authors: Punniyakotti Saranya , Saxena Pal Rashmi , Khera Kanav , Katiyar Deepti 
Published: April 2023

Abstract:
Secondary metabolites of natural origin exhibit numerous pharmacological activities, like
anti-inflammatory and anti-oxidant effects. Lipid peroxidation has been observed to be prevented by
terminating free radical chains and chelating redox active metal ions. These properties of the secondary
products can also aid in preventing carcinoma. Many traditional and emerging plants are blessed
with plenty of unexplored phytometabolites, which contain the probability to carry huge antineoplastic
potential. Acetogenins are anticancer compounds that kill tumor cells through a variety and
series of developmental methods. They are very powerful apoptosis inducers that can regulate the exclusion
of chemotherapy medicines from cancer cells. Chalcone is a pharmacologically active molecule
that can be found in both natural and manufactured products. Marine species, which are also examples
of naturally derived drug sources, such as algae, sponges, tunicates, and bryozoans, have
emerged as important components of choice for the separation of novel anticancer drugs obtained
from marine sources. Bacteria of marine origin are the source of new drug discoveries and therapeutic
targets, which are being explored to unprecedented heights, and they have proven to be sources of various
medicinal agents, such as antibiotics, etc. Numerous secondary metabolites have been isolated
from marine fungi that were active biologically, structurally unique, and also therapeutically beneficial.
So far, almost 1000 secondary metabolites have been found, the majority of which are exclusive
to lichens. This mini-review discusses different aspects related to the natural derivatives obtained from
various sources, which play a pivotal role as anti-neoplastic agents.
Endocrine, Metabolic, and Immune Pathogenesis of Postmenopausal
Osteoporosis. Is there a Therapeutic Role in Natural Products?
Authors: Lisco Giuseppe , Triggiani Domenico , Giagulli Vito Angelo , De Pergola Giovanni , Guastamacchia Edoardo , Piazzolla Giuseppina , Jirillo Emilio , Triggiani Vincenzo 
Published: April 2023

Background:
Bone health relies on the equilibrium between resorption and new bone generation. Postmenopausal osteoporosis depends on estrogen deficiency which favorite bone re-sorption and elevated risk of fractures. Moreover, osteoporosis is characterized by a high release of proinflammatory cytokines suggesting the role of the immune system in the pathogenesis of this complex disease (immunoporosis).

Aims:
To review the pathophysiology of osteoporosis from an endocrinological and immunological viewpoint and treatments with a specific focus on nutraceuticals.

Methods:
PubMed/MEDLINE, Scopus, Google Scholar, and institutional web site were searched. Original articles and reviews were screened and selected by September 2022.

Results:
The activation of the Gut Microbiota-Bone Axis contributes to bone health by releasing several metabolites, including short-chain fatty acids (SCFAs), that facilitate bone mineralization directly and indirectly by the induction of T regulatory cells, triggering anti-inflammatory path-ways.

Conclusion:
Treatments of postmenopausal osteoporosis are based on lifestyle changes, calcium and vitamin D supplementation, and anti-resorptive and anabolic agents, such as bisphosphonates, Denosumab, Teriparatide, Romosozumab. However, phytoestrogens, polyphenols, probiotics, and polyunsaturated fatty acids may improve bone health by several mechanisms, including anti-in-flammatory properties. Specific clinical trials are needed to assess the efficacy/effectiveness of the possible anti-osteoporotic activity of natural products as add on to background treatment.
Insight on Vernonia Plant for its Pharmacological Properties: A Review
Authors: Mishra Neha , Gupta Ena , Singh Priyanka , Soni Shashi , Noor Uroosa 
Published: April 2023

Abstract:
Vernonia is a woody shrub of the family Asteraceae. Over 1500 species are distributed
in tropical and subtropical regions of Africa and Asia. There are more than 54 species known
to possess similar morphological features with the characteristic bitter taste. The pharmacological
properties of different parts like seeds, leaves, and roots are well documented in folk medicine.
They are rich in biologically active constituents such as alkaloids, phenolics, flavonoids,
terpenoids, steroid tannins, and carotenoids having broad therapeutic activities like antiinflammatory,
hypoglycemic, hyperlipidemia, antimicrobial, antitumor, antioxidative, antiproliferative,
antihypertensive, hepatoprotective, etc. The present study summarizes and discusses the
phytochemical profile, pharmacological properties, and toxicological effects of the Vernonia
plant.
Relación entre rasgos de mediciones corporales, rasgos de mediciones de la ubre y producción de leche de cabras Saanen en el distrito de Capricorn de Sudáfrica
Authors: Makamu Thlarihani Cynthia , Madikadike Molabe Kagisho , Mokoena Kwena , Tyasi Thobela Louis 
Published: April 2023

The association between body measurements and udder measurements can be used towards the improvement of milk yield. The objective of the study was to investigate the correlation between udder measurement traits and milk yield. The study was conducted at Sikline village in Mankweng, Capricorn district of Limpopo province, South Africa where a total number of 30 lactating Saanen goats were used. Pearson’s correlation technique was used for data analysis. The results showed a significant (P<0.05) correlation between distance between teats and milk yield (r= 0.45) and a highly negative significant (P˂0.01) correlation between teat diameter and milk yield (r= -0.57). Body weight and milk yield (r= 0.54) had a highly positive significant correlation (P˂0.01). The finding of the current study implies that body weight and distance between teats can be used to improve the milk yield in Saanen goats. The finding of the study might be used to predict the milk yield of Saanen goats. However, further studies need to be conducted on relation of body and udder measurements and milk yield using higher sample size.
Multiple solutions for eigenvalue problems involving the (p,q)-Laplacian
Authors:   ", Pucci Patrizia ,   Universita degli Studi di Perugia, Dipartimento di Matematica e Informatica, Via L. Vanvitelli, 1, 06123 Perugia, Italy e-mail: patrizia.pucci@unipg.it"
Published: April 2023

This paper is devoted to a subject that Professor Csaba Varga suggested during his frequent visits to the University of Perugia and in my regular stays at the "Babe s-Bolyai" University. More speci cally, continuing the work started in [7] jointly with Professor Varga, here we establish the existence of two nontrivial (weak) solutions of some one parameter eigenvalue (p,q)-Laplacian problems under homogeneous Dirichlet boundary conditions in bounded domains of R^N.
Trust evaluation in virtual software development teams using BERT-based language models
Authors: Zapata Sergio , Gallardo Facundo , Sevilla Gustavo , Torres Estela , Forradellas Raymundo 
Published: April 2023

Nowadays, people from different geographical areas can be closely related thanks to advances in information and communication technologies. This has a greater impact in software development organizations where their members form virtual work teams. In these new co-located work scenarios, the construction of interpersonal trust is more complex and its impact is very relevant in the performance of software development teams. This paper presents the results of the performanceevaluation of four pre-trained language models based on BERT applied to trust analysis tasks. For this work, a small dataset of 1453 comments obtained from software projects stored on Github was created. The evaluated language models achieved moderately good values, in the order of 0.84 for the F1-score metric, which augurs that with further research they could be significantly improved.
Capabilities of Thomson parabola spectrometer in various laser-plasma- and laser-fusion-related experiments
Authors: Tchórz Przemysław , Szymański Maciej , Rosiński Marcin , Chodukowski Tomasz , Borodziuk Stefan 
Published: April 2023

Abstract
The Thomson parabola spectrometer (TPS) [1] is a well-known, universal diagnostic tool that is widely used in laser plasma experiments to measure the parameters of accelerated ions. In contrast to other popular ion diagnostics, such as semiconductor detectors or ion collectors, the TPS is not greatly affected by electromagnetic pulses generated during high-power laser interaction with matter and can be tuned to acquire data in various energy ranges of accelerated ions, depending on the goal of the experiment. Despite the many advantages of this diagnostic device, processing the collected data is a difficult task and requires a lot of caution during interpretation of gathered results. In this work, we introduce the basic principles of operation and data analysis based on the numerical tool created specifically for the TPS designed at the Institute of Plasma Physics and Laser Microfusion, present a range of data obtained during various recent experiments in which our TPS was used, and highlight the difficulties in data analysis depending on the purpose of the experiment and the experimental setup.