bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel characteristics for immunophenotype, FISH pattern and molecular cytogenetics in synovial sarcoma
Authors: Zhong Ling ling , Huang Gao xiang , Xian Li ying , Wei Zong chen , Tang Zhi ping , Chen Qiu yue , Chen Hao , Tang Fang 
Published: May 2023

AbstractAs a rare and highly aggressive soft tissue sarcoma, the new immunophenotype, atypical FISH pattern and relevant molecular cytogenetics of synovial sarcoma (SS) remain less known, although it is characteristically represented by a pathognomonic chromosomal translocation t (X; 18) (p11.2; q11.2). Methodologically, the morphology was retrospectively analysed by using H&E staining, and immunohistochemical features were investigated by using markers that have been recently applied in other soft tissue tumors. Moreover, FISH signals for SS18 and EWSR-1 break-apart probes were examined. Finally, cytogenetic characteristics were analysed via RT-PCR and Sanger sequencing. Consequently, nine out of thirteen cases that were histologically highly suspected as SS were finally identified as SS via molecular analysis. Histologically, nine SS cases were divided into monophasic fibrous SS (4/9), biphasic SS (4/9) and poorly differentiated SS (1/9). Immunohistochemically, SOX-2 immunostaining was positive in eight cases (8/9) and PAX-7 immunostaining was diffusely positive in the epithelial component of biphasic SS (4/4). Nine cases showed negative immunostaining for NKX3.1 and reduced or absent immunostaining for INI-1. Eight cases showed typically positive FISH signalling for the SS18 break-apart probe, whereas one case exhibited an atypical FISH pattern (complete loss of green signalling, case 2). Furthermore, the SS18-SSX1 and SS18-SSX2 fusion genes were identified in seven cases and two cases, respectively. The fusion site in 8 out of 9 cases was common in the literature, whereas the fusion site in case 2 was involved in exon 10 codon 404 in SS18 and exon 7 codon 119 in SSX1 (which has not been previously reported), which notably corresponded to the complete loss of green signalling in the FISH pattern. Additionally, FISH analysis of the EWSR-1 gene in nine SS cases demonstrated aberrant signalling in three cases that were recognized as a monoallelic loss of EWSR-1 (1/9), an amplification of EWSR-1 (1/9) and a translocation of EWSR-1 (1/9). In conclusion, SS18-SSX fusion gene sequencing is obligatory for a precise diagnosis of SS when dealing with a confusing immunophenotype and atypical or aberrant FISH signalling for SS18 and EWSR-1 detection.
Effect of end-stage kidney disease on the return of spontaneous circulation in Taiwanese adults with out-of-hospital cardiac arrest
Authors: Hsieh Ming-Shun , Chattopadhyay Amrita , Lu Tzu-Pin , Liao Shu-Hui , Chang Chia-Ming , Lee Yi-Chen , Lo Wei-En , Wu Jia-Jun , Hsieh Vivian Chia-Rong , Hu Sung-Yuan , How Chorng-Kuang 
Published: May 2023

AbstractRescuing patients with out-of-hospital cardiac arrest (OHCA), especially those with end-stage kidney disease (ESKD), is challenging. This study hypothesizes that OHCA patients with ESKD undergoing maintenance hemodialysis have (1) higher rates of return of spontaneous circulation (ROSC) during cardio-pulmonary resuscitation (CPR) and (2) lower rates of hyperkalemia and less severe acidosis than those without ESKD. OHCA patients who received CPR between 2011 and 2020 were dichotomized into ESKD and non-ESKD groups. The association of ESKD with “any” and “sustained” ROSC were examined using logistic regression analysis. Furthermore, the effect of ESKD on hospital outcomes for OHCA patients who survived to admission was evaluated using Kaplan–Meier analysis. ESKD patients without “any” ROSC displayed lower potassium and higher pH levels than non-ESKD patients. ESKD was positively associated with “any” ROSC (adjusted-OR: 4.82, 95% CI 2.70–5.16, P < 0.01) and “sustained” ROSC (adjusted-OR: 9.45, 95% CI 3.83–24.13, P < 0.01). Kaplan–Meier analysis demonstrated ESKD patients had a non-inferior hospital survival than non-ESKD patients. OHCA patients with ESKD had lower serum potassium level and less severe acidosis compared to the general population in Taiwan; therefore, should not be treated under the stereotypical assumption that hyperkalemia and acidosis always occur.
Three-dimensional spatial interpolation for chlorophyll-a and its application in the Bohai Sea
Authors: Zhao Zihan , Xiao Rushui , Guo Junting , Zhang Yuming , Zhang Shufang , Lv Xianqing , Shi Honghua 
Published: May 2023

AbstractAssessing the health of coastal ecosystems is crucial for maintaining ecological balance. One significant indicator of water eutrophication is the distribution of chlorophyll-a (Chl-a), which makes obtaining a complete three-dimensional spatial distribution of Chl-a essential for assessment. This study utilized the linear radial basis function (RBF-Linear) method to obtain a comprehensive and reasonable spatial distribution of Chl-a. The method was applied to obtain the three-dimensional spatial field of Chl-a concentration in the Bohai Sea in March, May, August, and October from 2016 to 2018. The distribution pattern of Chl-a concentration in the Bohai Sea displayed characteristic spatial and temporal variations. Spatially, high Chl-a concentration was most concentrated in coastal waters, particularly in estuaries and mariculture areas. Temporally, there were two peaks in March and August. The total Chl-a and areas with high Chl-a concentration in four sub-regions of the Bohai Sea were also calculated to enable a comprehensive assessment of the marine ecological environment. By analyzing the temporal and spatial variation of Chl-a in the Bohai Sea and evaluating the marine ecological environment, we confirmed the feasibility and rationality of RBF-Linear. Our findings have the potential to contribute to improve the accuracy of ecological models and assessment of the satellite products.
Differences in gene regulation by TLR3 and IPS-1 signaling in murine corneal epithelial cells
Authors: Komai Seitaro , Ueta Mayumi , Nishigaki Hiromi , Mizushima Katsura , Naito Yuji , Kinoshita Shigeru , Sotozono Chie 
Published: May 2023

AbstractToll-like receptor 3 (TLR3) and interferon-beta promoter stimulator-1 (IPS-1) are associated with antiviral responses to double-stranded RNA viruses and contribute to innate immunity. We previously reported that conjunctival epithelial cell (CEC) TLR3 and IPS-1 pathways respond to the common ligand polyinosinic:polycytidylic acid (polyI:C) to regulate different gene expression patterns as well as CD11c + cell migration in murine-model corneas. However, the differences in the functions and the roles of TLR3 and IPS-1 remain unclear. In this study, we investigated the differences of TLR3 or IPS-1-induced gene expression in corneal epithelial cells (CECs) in response to polyI:C stimulation using cultured murine primary CECs (mPCECs) derived from TLR3 and IPS-1 knockout mice via comprehensive analysis. The genes associated with viral responses were upregulated in the wild-type mice mPCECs after polyI:C stimulation. Among these genes, Neurl3, Irg1, and LIPG were dominantly regulated by TLR3, while interleukin (IL)-6 and IL-15 were dominantly regulated by IPS-1. CCL5, CXCL10, OAS2, Slfn4, TRIM30α, and Gbp9 were complementarily regulated by both TLR3 and IPS-1. Our findings suggest that CECs may contribute to immune responses and that TLR3 and IPS-1 possibly have different functions in the corneal innate immune response.
Requirements‐related fault prevention during the transformation from formal specifications to programs
Authors: Li Jiandong , Liu Shaoying 
Published: May 2023

AbstractSoftware faults are costly to find and remove from programs. It is better to avoid inserting the faults in the first place. The authors identify requirements‐related faults that can arise during the transformation of formal specifications into programs, analyse each to discover its causes, and propose corresponding fault prevention methods. The approach works by analysing a specification, decomposing it into specification fragments with different levels like components, determining the correct implementation order among the components, and enabling automated code generation for the components and other low‐level specification fragments. The approach seeks to reduce the faults in programs significantly by guiding programmers to work effectively and productively. The authors evaluate the approach's performance experimentally and compare it to the performance of a fault‐prevention method with industry applications.
Photometric determination of the mass accretion rates of pre-main-sequence stars
Authors: Tsilia Styliani , De Marchi Guido , Panagia Nino 
Published: May 2023

Aims. We study the properties of low-mass stars recently formed in the field of the NGC 376 cluster in the Small Magellanic Cloud (SMC).
Methods. Using photometric observations acquired with the Hubble Space Telescope (HST) in the V, I, and Hα bands, we identify 244 candidate pre-main-sequence (PMS) stars showing Hα excess emission at the 5σ level and with Hα equivalent width of 20 Å or more. We derive physical parameters for all PMS stars, including masses, ages, and mass accretion rates. We compare the effective mass accretion rate of stars in NGC 376 to that of objects in the NGC 346 cluster, with NGC 346 featuring similar metallicity but higher total mass and gas density.
Results. We find a median age of 28 Myr for this population (with 25th and 75th percentiles at about 20 and 40 Myr, respectively), in excellent agreement with previous studies of massive stars in the same field. The PMS stars are rather uniformly distributed across the field, whereas massive stars are more clustered. The spatial distribution of PMS objects is compatible with them having formed in the centre of the cluster and then migrating outwards. We find that in NGC 376 the mass accretion rate is systematically lower than in NGC 346 for stars of the same mass and age. This indicates that, in addition to metallicity, there are other environmental factors affecting the rate of mass accretion onto PMS stars. Our observations suggest that the gas density in the star-forming region might play a role.
Effect of stellar rotation on the development of post-shock instabilities during core-collapse supernovae
Authors: Buellet A.-C. , Foglizzo T. , Guilet J. , Abdikamalov E. 
Published: May 2023

Context.The growth of hydrodynamical instabilities is key to triggering a core-collapse supernova explosion during the phase of stalled accretion shock, immediately after the birth of a proto-neutron star (PNS). Stellar rotation is known to affect the standing accretion shock instability (SASI) even for small rotation rates, but its effect on the onset of neutrino-driven convection is still poorly known.Aims.We assess the effect of stellar rotation on SASI when neutrino heating is taken into account as well as the effect of rotation on neutrino-driven convection. The interplay of rotation with these two instabilities affects the frequency of the modem = 2, which can be detected with gravitational waves at the onset of a supernova explosion.Methods.We used a linear stability analysis to study the dynamics of the accreting gas in the equatorial plane between the surface of the PNS and the stationary shock. We explored rotation effects on the relative strength of SASI and convection by considering a large range of specific angular momenta and neutrino luminosities.Results.The nature of the dominant non-axisymmetric instability developing in the equatorial post-shock region depends on both the convection parameter,χ, and the rotation rate. Equatorial convective modes withχ ≳ 5 are hampered by differential rotation. At smallerχ, however, mixed SASI-convective modes with a large angular scale,m = 1,  2,  3, can take advantage of rotation and become dominant for relatively low rotation rates, at which centrifugal effects are small. For rotation rates exceeding ∼30% of the Keplerian rotation at the PNS surface, a new instability regime is characterised by a frequency that, when measured in units of the post-shock velocity and radius,vsh/rsh, is nearly independent of the convection parameter,χ. A strong progradem = 2 spiral dominates over a large parameter range and is favorable to the production of gravitational waves. In this regime, a simple linear relation exists between the oscillation frequency of the dominant mode and the specific angular momentum of the accreted gas.Conclusions.Three different regimes of post-shock instabilities can be distinguished depending on the rotation rate. For low rotation rates (less than 10% of the Keplerian rotation at the PNS surface), differential rotation has a linear destabilising effect on SASI and a quadratic stabilising or destabilising effect on the purely convective equatorial modes depending on their azimuthal wavenumber. Intermediate rotation rates (10% to 30% of the Keplerian rotation) lead to the emergence of mixed SASI-convection-rotation modes that involve large angular scales. Finally, strong rotation erases the influence of the buoyancy and heating rate on the instability. This independence allows for a reduction in the parameter space, which can be helpful for gravitational wave analysis.
Meningitis in der Notaufnahme
Authors: Regner-Nelke Liesa , Ruck Tobias , Meuth Sven G. 
Published: May 2023

AbstractMeningitis describes an inflammation of the meninges of the brain and spinal cord, which, depending on the etiology, can be a serious disease with high lethality. The suspicion of
meningitis therefore requires rapid and adept action. In this paper, we explain the diagnostic and therapeutic approach to suspected meningitis in the emergency department.
Impact of Region-of-Interest Delineation on Stability and Reproducibility of Liver SNR Measurements in 68Ga-PSMA PET/CT
Authors: Fooladi Masoomeh , Rezaei Sahar , Aghahosseini Farahnaz , Salehi Yalda , Kasraie Nima , Sheikhzadeh Peyman 
Published: May 2023

Abstract
Objective This study aims to assess the impact of various regions of interest (ROIs) and volumes of interest (VOIs) delineations on the reproducibility of liver signal-to-noise-ratio (SNRliver) measurements, as well as to find the most reproducible way to estimate it in gallium-68 positron emission tomography (68Ga-PET) imaging. We also investigated the SNRliver-weight relationship for these ROIs and VOIs delineations.
Methods A cohort of 40 patients (40 males; mean weight: 76.5 kg [58–115 kg]) with prostate cancer were included. 68Ga-PET/CT imaging (mean injected activity: 91.4 MBq [51.2 MBq to 134.1 MBq] was performed on a 5-ring bismuth germanium oxide-based Discovery IQ PET/CT using ordered subset expectation maximization image reconstruction algorithm. Afterward, circular ROIs and spherical VOIs with two different diameters of 30 and 40 mm were drawn on the right lobe of the livers. The performance of the various defined regions was evaluated by the average standardized uptake value (SUVmean), standard deviation (SD) of the SUV (SUVSD), SNRliver, and SD of the SNRliver metrics.
Results There were no significant differences in SUVmean among the various ROIs and VOIs (p > 0.05). On the other hand, the lower SUVSD was obtained by spherical VOI with diameter of 30 mm. The largest SNRliver was obtained by ROI (30 mm). The SD of SNRliver with ROI (30 mm) was also the largest, while the lowest SD of SNRliver was observed for VOI (40 mm). There is a higher correlation coefficient between the patient-dependent parameter of weight and the image quality parameter of SNRliver for both VOI (30 mm) and VOI (40 mm) compared to the ROIs.
Conclusion Our results indicate that SNRliver measurements are affected by the size and shape of the respective ROIs and VOIs. The spherical VOI with a 40 mm diameter leads to more stable and reproducible SNR measurement in the liver.
Open Volar STT Ligament Reconstruction to Augment the Mathoulin's Arthroscopic Dorsal Capsuloligamentous Reconstruction: Technique Description and Case Reports
Authors: Smith Nicholas Charles , Yates Sally E. , Mettyas Tamer 
Published: May 2023

Abstract
Background The results of Mathoulin's arthroscopic dorsal capsuloligamentous reconstruction (ADCLR) are excellent in many patients with scapholunate instability, though less consistently good in higher grade instabilities. The purpose of this article is to describe a novel technique of volar scaphotrapeziotrapezoid (STT) reconstruction which may be used to augment rotational control of the scaphoid, in conjunction with the ADCLR, for use in European Wrist Arthroscopy Society (EWAS) grade IV/V instabilities.
Description of Technique Following completion of ADCLR, the STT joint is approached through the flexor carpi radialis sheath. The palmaris longus tendon is harvested. Fluoroscopy is used to site guide wires for tunnel placement in the distal scaphoid and the proximal trapezium; 3.5-mm tunnels are overdrilled in both bones, to a depth of 8 mm. The palmaris graft is then anchored in the scaphoid tunnel with a mini-DX SwiveLock anchor. The graft is tensioned, then anchored in the trapezium tunnel with another anchor.
Patients and Methods We retrospectively selected two young men heavy manual workers who had this procedure more than 12 months previously for scapholunate instability, with static radiographic abnormalities and a drive through sign (EWAS grade V). The patients were reviewed after 12 months, for assessment of visual analog scale, quick disabilities of the arm, shoulder, and hand, and patient-rated wrist/hand evaluation scores, range of motion, and grip strength.
Results Both patients had marked improvements of wrist comfort and function at 1 year, and were able to return to their normal duties at work and complete all activities of daily living with minimal symptoms.
Conclusion This volar STT reconstruction may expand the success of the Mathoulin's ADCLR into higher grade instabilities.
Unmasking the Culprit: Maternal Hyperthyroidism Presenting as Fetal Supraventricular Tachycardia and Hydrops
Authors: Bhalgat Parag , Bhalgat Pooja 
Published: May 2023

AbstractManagement of fetal supraventricular tachycardia at times can be tricky and challenging when they are secondary to underlying metabolic or hormonal problems. It can difficult to unmask the real culprit unless thorough evaluation is performed.
Broadening horizons in the diachronic and sociolinguistic study of Philippine English with the Twitter Corpus of
Philippine Englishes (TCOPE)
Authors: Gonzales Wilkinson Daniel Wong 
Published: May 2023

Abstract
This paper presents the Twitter Corpus of Philippine Englishes (TCOPE): a dataset of 27 million tweets amounting
to 135 million words collected from 29 cities across the Philippines. It provides an overview of the dataset, and then shows how
it can be employed to examine Philippine English (PhilE) and its relationship with extralinguistic factors (e.g. ethno-geographic
region, time, sex). The focus is on the patterns of variation involving four PhilE features: (1) irregular past tense morpheme
-t, (2) double comparatives, (3) subjunctive were, and (4) phrasal verb base
from. My analyses corroborate previous work and further demonstrate structured heterogeneity within PhilE, indicating
that it is a multifaceted and dynamic variety. TCOPE has shown itself to be useful for exploring both the “general” features of
contemporary PhilE and the different forms of variation within it. It contributes to a deeper understanding of Philippine
English(es) over time and in different social contexts.
‘It seems my enemy is about having malaria’
Authors: Ogoanah Felix Nwabeze 
Published: May 2023

Abstract
This study seeks to characterise the form of verbal irony common among Nigerians by identifying its motivation,
inherent properties, and communicative value. Data for this study comprised detailed field notes taken within the last five years
in contexts in which utterances occurred naturally. These were then tested among informants from diverse ethnic and linguistic
backgrounds at the University of Benin to determine the prevalence and motivation of the ironic utterances. In addition, 500
questionnaires were administered to a group of students and staff in the same institution. These were analysed using frequency
tables and simple percentages. Results support the claim that irony in this context is governed by a single cultural principle:
“You hurt yourself by admitting a negative situation.” Although the study draws heavily from the relevance-theoretic echoic
account, it seeks to reevaluate this account by suggesting that positive attitudes in negative situations are salient cultural
notions that underlie the echoic account in this context.
Dynamic effective charge in the continuum of the CDW-EIS model for ionization in ion–atom collisions: angular and energy dependence
Authors: Rojas M F , Quinto M A , Rivarola R D , Monti J M 
Published: May 2023

Abstract
In this work, a dynamic charge is employed in the continuum distorted wave–eikonal initial state theoretical model to describe the non-Coulomb potential of the residual target for single ionization in bare ion–multielectron atom collisions. A comparison between the well-known Belkić prescription and the effective charge depending on emission angle and energy in the final residual-target continuum state is shown. The obtained results show that this effective charge improves the description of double-differential cross sections for backward emission angles over the whole emission energy range allowing the calculation of simple differential and total cross sections.