bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: secondary analysis of a multicentre randomised clinical trial
Authors: Sánchez-Sánchez Juan Luis , de Souto Barreto Philipe , Antón-Rodrigo Iván , Ramón-Espinoza Fernanda , Marín-Epelde Itxaso , Sánchez-Latorre Marina , Moral-Cuesta Débora , Casas-Herrero Álvaro 
Published: December 2022

AbstractIntroductionThe World Health Organisation recently defined the construct of intrinsic capacity (IC), a function-based marker of older adult’s health encompassing all mental and physical capacities of the individual. Multicomponent physical exercise (MCE) is a potential intervention capable to maintain/increase IC at older age; however, evidence is scarce on the effects of MCE on IC in cognitively impaired pre-frail/frail older adults.MethodsSecondary analyses of a randomised clinical trial. One hundred and eighty-eight older outpatients (age = 84.06 ± 4.77, 70.2% women) presenting with pre-frailty/frailty (according to Fried Criteria) and mild cognitive impairment (MCI)/mild dementia were recruited in the Geriatric clinics of three tertiary hospitals in Spain. Subjects were randomised to participate in the 12-week home-based individualised Vivifrail MCE or usual care. An IC index was created based on the z-score of the locomotion (Short Physical Performance Battery), cognitive (Montreal Cognitive Assessment), psychology (15-item Geriatric Depression Scale Yesavage) and vitality (handgrip strength) domains.ResultsAfter the 3-month intervention, linear mixed models showed significant between-group differences in the evolution of the IC composite score (β=0.48; 95% confidence interval [CI] = 0.24, 0.74; P &lt; 0.001), IC Locomotion (β = 0.42; 95% CI = 0.10, 0.74; P &lt; 0.001), IC Cognition (β = 0.45; 95% CI = 0.03, 0.87; P &lt; 0.05) and IC Vitality domains (β = 0.50; 95% CI = 0.25, 0.74 at 3-month) favouring the MCE group.ConclusionsThe 12-week Vivifrail multicomponent exercise program is an effective strategy to enhance IC, especially in terms of locomotion, cognition and vitality IC domains in community-dwelling older adults with pre-frailty/frailty and MCI/mild dementia, compared to usual care.
Cooperation of structural motifs controls drug selectivity in cyclin-dependent kinases: an advanced theoretical analysis
Authors: Wang Lingling , Xu Lei , Wang Zhe , Hou Tingjun , Hao Haiping , Sun Huiyong 
Published: December 2022

Abstract
Understanding drug selectivity mechanism is a long-standing issue for helping design drugs with high specificity. Designing drugs targeting cyclin-dependent kinases (CDKs) with high selectivity is challenging because of their highly conserved binding pockets. To reveal the underlying general selectivity mechanism, we carried out comprehensive analyses from both the thermodynamics and kinetics points of view on a representative CDK12 inhibitor. To fully capture the binding features of the drug-target recognition process, we proposed to use kinetic residue energy analysis (KREA) in conjunction with the community network analysis (CNA) to reveal the underlying cooperation effect between individual residues/protein motifs to the binding/dissociating process of the ligand. The general mechanism of drug selectivity in CDKs can be summarized as that the difference of structural cooperation between the ligand and the protein motifs leads to the difference of the energetic contribution of the key residues to the ligand. The proposed mechanisms may be prevalent in drug selectivity issues, and the insights may help design new strategies to overcome/attenuate the drug selectivity associated problems.
Long-term post-traumatic growth after natural disasters: A scoping review of contextual influences
Authors: Nguyen Hanh , Pope David , Harms Louise 
Published: December 2022

Abstract
Social work is invested in supporting positive change for individuals and communities grappling with natural disasters within a changing climate. This scoping review investigated the extent, range and nature of longitudinal research examining contextual influences on experiences of post-traumatic growth (PTG) following a natural disaster. Literature searches of four databases were conducted from December 2021 to April 2022 to identify thirty-two longitudinal studies. Thematic analysis identified themes relating to the impacts of contextual factors on experiences of individual growth, across relational, social, structural and time dimensions. The quality and quantity of relational and social support were found to be significant in facilitating growth; these findings have important implications for social work practice in disaster recovery, which utilises a person-in-environment lens to strengthen the contextual resources that support positive changes. Other contextual factors that may influence PTG, including structural, cultural and time factors, remain understudied. In advocating for a critical person-in-environment approach, social work is uniquely positioned to move beyond existing individualistic conceptualisations and contribute a more holistic understanding of growth to enhance future disaster recovery interventions.
Macrophage polarization in diabetic wound healing
Authors: Wu Xingqian , He Wenjie , Mu Xingrui , Liu Ye , Deng Junyu , Liu Yiqiu , Nie Xuqiang 
Published: December 2022

Abstract
Impaired wound healing is one of the severe complications of diabetes. Macrophages have been shown to play a vital role in wound healing. In different wound environments, macrophages are classified into two phenotypes: classically activated macrophages and alternatively activated macrophages. Dysregulation of macrophage phenotypes leads to severely impaired wound healing in diabetes. Particularly, uncontrolled inflammation and abnormal macrophage phenotype are important reasons hindering the closure of diabetic wounds. This article reviews the functions of macrophages at various stages of wound healing, the relationship between macrophage phenotypic dysregulation and diabetic wound healing and the mechanism of macrophage polarization in diabetic wound healing. New therapeutic drugs targeting phagocyte polarization to promote the healing of diabetic wounds might provide a new strategy for treating chronic diabetic wound healing.
“White at heart”: making race in Marine Corps recruitment advertising
Authors: Favara Jeremiah , Brinson Clark 
Published: December 2022

AbstractFocusing on interviews with advertising professionals, this article identifies racialized logics at work in the cultural production of United States Marine Corps recruitment advertisements and reads them as crucial contributors to the late-stage war on terror as a racial project. Characterized by the emergence of post-racial discourses, an ongoing commitment to warfare, and an embrace of diversity and inclusion within the U.S. military as hallmarks of American exceptionalism, the late-stage war on terror was represented in recruiting ads as a war fought by a racially representative Marine Corps dedicated to benevolence. Identifying primary themes through which race was constructed and contested in Corps recruitment advertising between 2012 and 2016, this article makes visible the processes through which racial ideologies manifest in cultural production. Though seemingly guided by a commitment to inclusion, the production of recruitment materials consolidated Whiteness while making limited space for the representation of a racially diverse military.
Beyond badhombres,mamacitas, and borders: rethinking representation ofMexicanidadin 2017 animationCoco
Authors: Dosch Emily A , Khrebtan-Hörhager Julia 
Published: December 2022

AbstractThe release of Coco in 2017 came as a cultural reaffirmation for many Mexicans who have previously seen themselves represented in animation as heavily-accented maids or comedic sidekicks included to forward the narrative of the White hero. Coco brought to screen the first animated Disney feature film with a Mexican protagonist. If previous animated Latinx representation has consistently relied on the same repeated archetypes (bandidos, bad hombres, machos, the constantly pregnant Latina, etc.), Coco took a different approach: celebrating mestizaje and contradictions of Mexican identities, and embracing a culturally nuanced portrayal of Mexicanidad. We explore how exactly those contradictions and paradoxes happen, and what they mean for the affected community. We argue that Coco subverts negative, narrow stereotypes by highlighting the complexities of Mexicanidad, while simultaneously paving the way for improved Latinx representation in children’s animation.
Metabolomics-Based Identification of Metabolic Dysfunction in Frailty
Authors: Westbrook Reyhan , Zhang Cissy , Yang Huanle , Tian Jing , Guo Shenghao , Xue Qian-Li , Walston Jeremy , Le Anne , Abadir Peter M 
Published: December 2022

Abstract
Dysregulation of energy producing metabolic pathways has been observed in older adults with frailty. In this study, we used liquid chromatography–mass spectrometry technology to identify aging- and frailty-related differences in metabolites involved in glycolysis, the tricarboxylic (TCA) cycle, and other energy metabolism-related pathways in the serum of a cohort of community-dwelling adults aged 20–97 (n = 146). We also examined the relationship between serum levels of metabolites and functional measures, physical frailty, and risk status for adverse health outcomes. We observed elevated levels of TCA cycle and glycolytic intermediates in frail subjects; however, the differences in the levels of ATP and other energy metabolites between young, nonfrail, and frail adults were not significant. Instead, we found that serum levels of neurotransmitters N-acetyl-aspartyl-glutamate, glutamate, and γ-aminobutyric acid were significantly elevated in older adults with frailty. These elevations of glycolytic and TCA cycle intermediates, and neurotransmitters may be part of the biological signature of frailty.
SlMYB72 affects pollen development by regulating autophagy in tomato
Authors: Wu Mengbo , Zhang Qiongdan , Wu Guanle , Zhang Lu , Xu Xin , Hu Xiaowei , Gong Zehao , Chen Yulin , Li Zhengguo , Li Honghai , Deng Wei 
Published: December 2022

AbstractThe formation and development of pollen are among the most critical processes for reproduction and genetic diversity in the life cycle of flowering plants. The present study found that SlMYB72 was highly expressed in the pollen and tapetum of tomato flowers. Downregulation of SlMYB72 led to a decrease in the amounts of seeds due to abnormal pollen development compared with wild-type plants. Downregulation of SlMYB72 delayed tapetum degradation and inhibited autophagy in tomato anther. Overexpression of SlMYB72 led to abnormal pollen development and delayed tapetum degradation. Expression levels of some autophagy-related genes (ATGs) were decreased in SlMYB72 downregulated plants and increased in overexpression plants. SlMYB72 was directly bound to ACCAAC/ACCAAA motif of the SlATG7 promoter and activated its expression. Downregulation of SlATG7 inhibited the autophagy process and tapetum degradation, resulting in abnormal pollen development in tomatoes. These results indicated SlMYB72 affects the tapetum degradation and pollen development by transcriptional activation of SlATG7 and autophagy in tomato anther. The study expands the understanding of the regulation of autophagy by SlMYB72, uncovers the critical role that autophagy plays in pollen development, and provides potential candidate genes for the production of male-sterility in plants.
Effectiveness of Vitamin D Supplementation on Disease Course in Inflammatory Bowel Disease Patients: Systematic Review With Meta-Analysis
Authors: Valvano Marco , Magistroni Marco , Cesaro Nicola , Carlino Giorgio , Monaco Sabrina , Fabiani Stefano , Vinci Antonio , Vernia Filippo , Viscido Angelo , Latella Giovanni 
Published: December 2022

Abstract

Background
The vitamin D role in bone metabolism is well known; however, recent evidence suggests the impact of vitamin D in immune modulation and its implications in immune-mediated diseases, including inflammatory bowel disease (IBD).

Method
We performed a systematic review with meta-analysis by a specific protocol (PROSPERO: CRD42022311184; March 2022, https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=311184). Randomized clinical trials involving IBD patients treated with vitamin D supplementation, compared with placebo, that evaluated the risk of clinical relapse and disease activity were included. Literature search was performed using Medline, Scopus, and Cochrane CENTRAL through January 2022.

Results
Out of 1448 articles, 12 (11 full-texts and 1 abstract) were included. Seven randomized clinical trials reported data on the clinical relapse as dichotomous outcome, while 7 studies reported data on disease activity expressed as continuous variables. The pooled risk ratio of clinical relapse was 0.64 (95% confidence interval, 0.46-0.89; I2 = 25%) among 458 IBD patients. However, this seems to be solid only in Crohn’s disease (CD) patients. In fact, only 2 studies, involving 67 patients with ulcerative colitis, were included in the analysis. CD patients in clinical remission had a strong significant risk reduction in clinical relapse (risk ratio, 0.47; 95% confidence interval, 0.27-0.82; I2 = 0%), suggesting that it could be a specific subgroup with maximum clinical benefit of vitamin D supplementation.

Conclusions
This meta-analysis shows that vitamin D supplementation can reduce the risk of clinical relapse in IBD patients, especially in CD patients in clinical remission. In a subgroup analysis, it was not significant (due to small number of studies and low number of patients), and well-powered studies are needed, in particular for ulcerative colitis patients.
Turtles, TEDs, tuna, dolphins, and diffusion of innovations: key drivers of adoption of bycatch reduction devices
Authors: Jenkins Lekelia D 
Published: December 2022

AbstractFisheries extension programmes frequently fail to secure mandatory or voluntary adoption of bycatch reduction devices and techniques. Approaches for improving the outcomes of extension programmes are often based on ad hoc assessments and do not consider human behaviour or change theories. This paper offers an in-depth analysis of extension activities that led to various adoption outcomes in two prominent bycatch case studies in the United States: turtle excluder devices in shrimp trawl fisheries and dolphin bycatch in the tuna purse seine fishery. Using a grounded theory approach to text analysis of interviews and documents, I examine five periods of voluntary or mandatory adoption efforts. I explain the outcomes through the lens of diffusion of innovation theory. The most effective extension programme involved informative and persuasive efforts, enforced regulations, and commercially practical bycatch reduction devices. Voluntary adoption occurred under exceptional circumstances of public and political pressure and a device that offered substantial benefits to the adopter. The two periods of successful adoption applied the most core principles of diffusion theory. This paper concludes with recommendations for how change agents can apply diffusion theory to future fisheries extension programmes to improve the adoption of bycatch reduction devices.
Manufacture and Characterization of Good Manufacturing Practice-Compliant SARS-COV-2 Cytotoxic T Lymphocytes
Authors: Chu Yaya , Milner Jordan , Lamb Margaret , Maryamchik Elena , Rigot Olivia , Ayello Janet , Harrison Lauren , Shaw Rosemarie , Behbehani Gregory K , Mardis Elaine R , Miller Katherine , Prakruthi Rao Venkata Lakshmi , Chang Hsiaochi , Lee Dean , Rosenthal Elana , Kadauke Stephan , Bunin Nancy , Talano Julie-An , Johnson Bryon , Wang Yongping , Cairo Mitchell S 
Published: December 2022

AbstractBackgroundCoronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 virus-specific cytotoxic T-cell lymphocytes (vCTLs) could provide a promising modality in COVID-19 treatment. We aimed to screen, manufacture, and characterize SARS-CoV-2–vCTLs generated from convalescent COVID-19 donors using the CliniMACS Cytokine Capture System (CCS).MethodsDonor screening was done by stimulation of convalescent COVID-19 donor peripheral blood mononuclear cells with viral peptides and identification of interferonγ (IFN-γ)+ CD4 and CD8 T cells using flow cytometry. Clinical-grade SARS-CoV-2–vCTLs were manufactured using the CliniMACS CCS. The enriched SARS-CoV-2–vCTLs were characterized by T-cell receptor sequencing, mass cytometry, and transcriptome analysis.ResultsOf the convalescent donor blood samples, 93% passed the screening criteria for clinical manufacture. Three validation runs resulted in enriched T cells that were 79% (standard error of the mean 21%) IFN-γ+ T cells. SARS-CoV-2–vCTLs displayed a highly diverse T-cell receptor repertoire with enhancement of both memory CD8 and CD4 T cells, especially in CD8 TEM, CD4 TCM, and CD4 TEMRA cell subsets. SARS-CoV-2–vCTLs were polyfunctional with increased gene expression in T-cell function, interleukin, pathogen defense, and tumor necrosis factor superfamily pathways.ConclusionsHighly functional SARS-CoV-2–vCTLs can be rapidly generated by direct cytokine enrichment (12 hours) from convalescent donors.Clinical Trials RegistrationNCT04896606.
An Interactive Design Framework for Children’s Apps for Enhancing Emotional Experience
Authors: Chen Kaiqing 
Published: December 2022

AbstractYoung children’s user experiences of educational applications (apps) can potentially support their cognitive development and improve the quality of parent–child relationships. However, to realize such potential, app designers must consider children’s emotional needs. Through a comprehensive review of the relevant literature, this paper develops an interactive design framework that can trigger three positive emotions, which is then used as a scale to conduct a design analysis of 72 apps available on the Australian and Chinese Apple App Store. We found that the interactive design scale based on emotional design is feasible; and an interactive design method that focuses on emotions affects the emotional benefits of parent–child users from apps and obtaining higher user ratings. It is thus demonstrated that paying attention to these design criteria will affect the emotional benefits young children receive from apps, thereby increasing users’ interest and support for the product. Lastly, we discuss the implications of improving the methods emotional experience and encourage future designers to bridge the gap between research and practice.
Active social media use and its impact on well-being — an experimental study on the effects of posting pictures on Instagram
Authors: Krause Hannes-Vincent , große Deters Fenne , Baumann Annika , Krasnova Hanna 
Published: December 2022

Abstract
Active use of social networking sites (SNSs) has long been assumed to benefit users’ well-being. However, this established hypothesis is increasingly being challenged, with scholars criticizing its lack of empirical support and the imprecise conceptualization of active use. Nevertheless, with considerable heterogeneity among existing studies on the hypothesis and causal evidence still limited, a final verdict on its robustness is still pending. To contribute to this ongoing debate, we conducted a week-long randomized control trial with N = 381 adult Instagram users recruited via Prolific. Specifically, we tested how active SNS use, operationalized as picture postings on Instagram, affects different dimensions of well-being. The results depicted a positive effect on users’ positive affect but null findings for other well-being outcomes. The findings broadly align with the recent criticism against the active use hypothesis and support the call for a more nuanced view on the impact of SNSs.
Whose media freedom is being defended? Norm contestation in international media freedom campaigns
Authors: Scott Martin , Bunce Mel , Myers Mary , Fernandez Maria Carmen 
Published: December 2022

AbstractThis article analyses how international advocacy campaigns approach and define media freedom, and what influences this process. It does this through a two-year case study of the Media Freedom Coalition—an intergovernmental partnership of over 50 countries—that included 55 interviews with key stakeholders, observations, and document analysis. This revelatory case sheds light on how norms of media freedom are constructed and contested on the international stage, and their implications for journalists, media freedom and geo-politics. We show that the Coalition adopted a state-centric, accountability-focused, and negative understanding of media freedom. This discourse legitimized a narrow, reactive, and “resource-light” approach to supporting media freedom, focused on “other” countries. We argue that critical norm research provides a helpful prism for understanding this Coalition’s operations, and the global politics of media freedom more generally. These findings have important implications for understandings of “norm entrepreneurship,” “media imperialism,” and “media freedom” itself.
Extended salvage surgery after high-dose chemoradiation therapy for tumors in the cervico-thoracic junction with invasion of the chest wall and the spine: a case series
Authors: Wiendieck Kurt , Dörfler Arnd , Sommer Björn 
Published: December 2022

Abstract
The treatment of malignant tumors localized in the upper thoracic cavity and involving the spine at the cervico-thoracic junction (CTJ) is challenging. We report on three patients with malignant tumors invading the thoracic inlet and the spine at the CTJ. All three patients underwent radical tumor resection and 360° spine fusion following the posterior pedicle screw instrumentation and anterior vertebrectomy combined with implantation of an expandable titanium cage. Postoperatively, a mild paresis with hypesthesia of the ipsilateral arm occurred in one patient because of brachial plexus involvement. Two patients were still alive at last follow-up after 83 and 143 months, the third patient succumbed to tumor progression 13 months after extended salvage surgery. We display the possibilities of extended ‘salvage’ therapy in well-selected patients that were deemed hopeless regarding neurological function, biomechanical stability and tumor control after multiple courses of combined radio-chemotherapy.
Bilateral ureteroinguinal hernia into the scrotum repaired in a staged fashion
Authors: Beckermann Jason , Giese Drake , Rentzepis Michael , Johnson Christopher , Wildenberg Joseph 
Published: December 2022

Abstract
Bilateral ureteroinguinal hernia is a rare presentation with only five cases previously presented in the literature. We describe a 60-year-old male who was diagnosed with large bilateral hernias extending into the scrotum containing redundant ureters. Both hernias were repaired in staged fashion with retrograde temporary ureteral stent placement and modified Lichtenstein technique. Follow-up computerized tomography imaging with &gt;5 years follow-up revealed intact repairs with no evidence of urinary obstruction.