bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomarcadores para el diagnóstico del síndrome de reconstitución inmune
Authors: Osorio Mazo Sara Isabel 
Published: March 2023

Introducción: el síndrome inflamatorio de reconstitución inmune es una complicación clínica dada en algunas personas infectadas con el virus de la inmunodeficiencia humana (VIH) luego de empezar la terapia antirretroviral; se destaca por la producción de citoquinas proinflamatorias, que se han estudiado como posibles biomarcadores que puedan orientar para el diagnóstico y pronóstico de esta condición clínica.
Objetivo: llevar a cabo una revisión actualizada de los avances en los biomarcadores para el diagnóstico de SIRI, resaltando la importancia de las moléculas inflamatorias y los exosomas, tanto en su patogénesis como un posible Gold estándar para la confirmación de este estado inflamatorio.
Metodología: se realizó una revisión bibliográfica en bases de datos, como Science Direct, PubMed, Scopus y Medline, partiendo de los siguientes términos MeSH: síndrome inflamatorio de reconstitución, enfermedades del sistema inmune, biomarcadores, fármacos antiVIH, plasma.
Conclusión: cada vez existen más avances en la identificación de moléculas que pueden servir como biomarcadores de SIRI, buscando un oportuno diagnóstico, monitoreo de la progresión clínica, mejor respuesta al tratamiento y más hallazgos sobre la fisiopatología, pero persiste la necesidad de encontrar un Gold estándar que proporcione criterios para su sospecha y confirmación.
Anemia aplásica: un nuevo reto farmacológico en la práctica clínica
Authors: Robledo Barrios Isabela María 
Published: March 2023

Introducción: la anemia aplásica (AA) es una enfermedad poco frecuente, caracterizada por presentar una insuficiencia en la médula ósea y una pancitopenia, sin rastro de procesos mieloproliferativos o fibróticos.
Objetivo: conocer los diversos tratamientos farmacológicos usados en la terapia inmunosupresora (IST) en la AA; adicionalmente, se profundizará en la respuesta de los pacientes frente a la IST y los mecanismos de acción de los fármacos utilizados.
Metodología: se realizó una búsqueda sistemática en las bases de datos de literatura médica como PUBMED, British Medical Journal, New England Journal, entre otros. Se incluyeron artículos tanto en inglés como en español.
Conclusiones: el manejo de la anemia aplásica continúa representando un reto para la medicina moderna; no obstante, se ha desarrollado un gran número de nuevas opciones terapéuticas para tratar a los pacientes.
Permeability and elastic properties of rocks from the northern Hikurangi margin: Implications for slow-slip events
Authors: Tisato Nicola , Bland Carolyn , Avendonk Harm Van , Bangs Nathan , Alamoudi Omar , Olsen Kelly , Gase Andrew 
Published: March 2023

Fluid flow and pore-pressure cycling are often invoked as controls to
slow slip events (SSEs), such as those that frequently occur at the
northern Hikurangi margin (HM) of New Zealand. To better understand
fluid flow in the forearc system, we examined the relationship between
elastic properties, compaction, porosity, and permeability of Cretaceous
to Pliocene mudstones from the Raukumara peninsula. We found that the
permeability of the deep wedge is too low to drain fluids, but
fracturing increases permeability by orders of magnitude, making
fracturing key for fluid flow. In weeks to months, plastic deformation
and clay swelling heal the fractures restoring the initial permeability.
We conclude that overpressures at the northern HM might partly dissipate
during SSEs due to enhanced permeability near faults. However, in the
weeks to months following an SSE, healing in the prism will lower
permeability, forcing pore pressure to rise and a new SSE to occur.
PAPER SUBMITTED TO GEOPHYSICAL RESEARCH LETTERS - AGU
How Does High Uncertainty in Accounting Estimates Impact Auditor Litigation Risk? Opposite Effects in Jury Trials and Attorneys’ Out-of-Court Settlements
Authors: Fingland Sean G. , Pickerd Jeffrey S. , Piercey M. David 
Published: March 2023

SUMMARY
Research suggests that the amount of inherent uncertainty in contemporary accounting estimates has increased in recent years, potentially increasing audit litigation risk. We review a recent study that finds that high estimate uncertainty impacts auditor litigation risk in opposite directions, depending on whether the litigation is decided in a jury trial or settled by attorneys out of court. Mock jurors and attorneys specialized in corporate and securities law read the same case about an alleged undetected material misstatement, with jurors judging auditor negligence and attorneys planning proposed out-of-court settlement negotiations on behalf of auditors. Results show that, under common conditions, mock jurors found auditors less negligent when estimate uncertainty was high. However, attorneys predicted the mock jurors to find auditors more negligent when estimate uncertainty was high, leading them to concede more on behalf of auditors in their proposed settlements.
The Chd4 helicase regulates chromatin accessibility and gene expression critical for β-cell function in vivo
Authors: Davidson Rebecca K. , Kanojia Sukrati , Wu Wenting , Kono Tatsuyoshi , Xu Jerry , Osmulski Meredith , Bone Robert N. , Casey Nolan , Evans-Molina Carmella , Sims Emily K. , Spaeth Jason M. 
Published: March 2023

<p> </p>
<p>The transcriptional activity of Pdx1 is modulated by a diverse array of coregulatory factors that govern chromatin accessibility, histone modifications, and nucleosome distribution. We previously identified the Chd4 subunit of the Nucleosome Remodeling and Deacetylase complex as a Pdx1-interacting factor. To identify how loss of Chd4 impacts glucose homeostasis and gene expression programs in β-cells <em>in vivo</em>, we generated an inducible-β-cell-specific Chd4 knockout mouse model. Removal of <em>Chd4</em> from mature islet β-cells rendered mutant animals glucose intolerant, in part due to defects in insulin secretion. We observed an increased ratio of immature:mature insulin granules in <em>Chd4</em>-deficient β-cells that correlated with elevated levels of proinsulin both within isolated islets and from plasma following glucose stimulation <em>in vivo</em>. RNA- and ATAC-Sequencing showed that lineage-labeled <em>Chd4</em>-deficient β-cells have alterations in chromatin accessibility and altered expression of genes critical for β-cell function, including <em>MafA</em>,<em> Slc2a2</em>,<em> Chga</em>, and <em>Chgb</em>. Knockdown of <em>CHD4 </em>from a human β-cell line revealed similar defects in insulin secretion and alterations in several β-cell-enriched gene targets. These results illustrate how critical Chd4 activities are in controlling genes essential for maintaining β-cell function.</p>
Impact of polymorphism in the β2-receptor gene on the metabolic response to epinephrine after repeated hypoglycemia
Authors: Rokamp Kim Z. , Dela Flemming , Secher Niels H. , Grønlykke Lars , Thorsteinsson Birger , Pedersen-Bjergaard Ulrik 
Published: March 2023

<p> </p>
<p>The β2-receptor mediates the metabolic response to epinephrine. This study investigates the impact of the β2-receptor gene (<em>ADRB2) </em>polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypoglycemia.</p>
<p>Twenty-five healthy male subjects selected according to <em>ADRB2</em> genotype being homozygous for either Gly16 (GG; n=12) or Arg16 (AA; n=13) participated in 4 trial days (D1-4), D1pre and D4post with epinephrine 0.06 ug kg-1 min-1 infusion, and D2hypo1-2 and D3hypo3 with three periods of hypoglycemia by an insulin-glucose clamp.</p>
<p>At D1pre the insulin (44 ± 8 vs. 93 ± 13 pmol l-1 h; <em>P</em> = 0.0051) and glycerol (79 ± 12 vs. 115 ± 14 μmol l-1 h; <em>P</em> = 0.041) and free fatty acids (FFA) (724 ± 96 vs. 1113 ± 140 μmol l-1 h; <em>P</em> = 0.033) responses (mean ± SEM of area under the curve) to epinephrine were decreased in AA subjects compared to GG subjects but without difference in glucose response. There were no difference in response to epinephrine between genotype groups after repetitive hypoglycemia at D4post.</p>
<p>The metabolic substrate response to epinephrine is decreased in AA subjects compared to GG subjects, but without difference between genotype groups after repetitive hypoglycemia.</p>
The Nordic Dimension in Education – Between Myth and Reality
Authors: Krejsler John Benedicto 
Published: March 2023

The article is an introduction to the special double issue of Nordic Studies in Education poses and elaborates upon the question of whether there is such a thing as a Nordic dimension in education. And, if so, what then are the defining similarities and differences in educational terms between the five small countries Denmark, Finland, Iceland, Norway and Sweden? This special issue follows up on the 2nd Annual Nordic Educational Conversation held on 23 September 2021, where the Nordic Educational Research Association invited participants to a discussion on the theme of the Nordic dimension in education and whether it is a myth or a living reality.
Acceso a tecnologías en el rendimiento universitario en tiempos del covid-19: análisis de asociación por clústeres
Authors: Jiménez García Martha , Gómez Miranda Pilar , Romero García José Antonio 
Published: March 2023

Ante los conflictos generados por el covid-19 en el ámbito educativo, las instituciones de educación superior se vieron en la necesidad de trasladar sus actividades al plano virtual, lo que modificó significativamente las formas de enseñanza y aprendizaje, y provocó nuevos retos y desafíos para el rendimiento académico de los estudiantes. En este contexto, el objetivo de la presente investigación fue analizar la asociación entre el rendimiento académico y el número de días de inactividad por covid-19. Para tal fin, se utilizó una metodología cuantitativa descriptiva de análisis no supervisado en una universidad pública de la Ciudad de México.
Entre los resultados obtenidos, se encontró que en su mayoría el promedio de calificaciones de los estudiantes fue de 7.9 y 8.5, con una media de 8.2. Asimismo, se decidió dividir a los alumnos en tres grupos (clústeres) según su rendimiento académico, y se encontró una asociación entre el rendimiento y el uso de las tecnologías de información (TI). En conclusión, se determinó que el uso de las TI está asociado con un mayor rendimiento académico de los estudiantes universitarios, a pesar de estudiar en un entorno afectado por la pandemia de covid-19. Por lo tanto, se considera importante garantizar el acceso de todos los estudiantes a estas herramientas mediante una buena conectividad a internet.
Russian Randomized Trial to Select Optimal Antibiotic Prophylaxis in Radical Cystectomy: Initial Results of MACS-TRIAL (NCT05392634)
Authors: Nosov A. K. , Berkut M. V. , Mamizhev E. M. , Galunova T. Yu. , Rumyantseva D. I. , Semeyko D. P. , Reva S. A. , Konyashkina S. Yu. 
Published: March 2023

Introduction. The key treatment for high-risk non-invasive bladder tumor or invasive urothelial cancer remains radical cystectomy (RCE), which provides the best survival rates. At the same time, the incidence of infectious complications in a number of studies reaches 33%, which in most cases causes repeated hospitalizations and disrupts the Enhanced Recovery After Surgery (ERAS) guidelines. Therefore, research into effective alternations of antibiotic prophylaxis remains relevant.Materials and methods. The MACS trial is a Russian Phase 3 study with a prospective randomized set of participants to assess the incidence of infectious complications after RCE in the context of the ERAS guidelines (intermediate data snapshot after including 39% of the data). Detailed inclusion and exclusion criteria are published on ClinicalTrials. gov, ID – NCT05392634. The study has been approved by the Local Ethics Committee, No. 1/129 of April 28, 2022. Statistical data processing was performed with StatPlus:Mac LE.Results and discussion. 36 patients were included in the study (39% of the expected sample). For the period from May 30, 2022 to February 01, 2023. A heterotopic Bricker reservoir was formed intracorporeally in 83.3% of cases (30/36), an orthotopic J-pouch reservoir was created in 13.8% of cases (5/36) and in 2.9% of cases (1/36) the urodereating stage was completed with ureteral clipping. No significant differences were revealed in urine bacterial contamination before surgery. However, in group A, the incidence of positive bacterial cultures, when the ureteric intubators were removed, was 2-fold higher than in the prolonged antibiotic therapy group: 7/14 cases (50.0%) and 3/12 cases (25.0%), respectively. In group B, the risk of complications in the prolonged antibiotic therapy group reduced by 47% within 30 days after RCE (HR 0.53 (95CI %: 0.21-1.32).Conclusion. An intermediate data snapshot in MACS study revealed that RCE was associated with a high risk of early postoperative infectious complications. The prognostic significance of systemic inflammation indices as predictors of infectious complications subject to further evaluation in the remaining 61% of cases.
Robot-Assisted Surgery in Treating Postoperative Strictures of Lower Third of Ureter
Authors: Mosoyan M. S. , Shanava G. Sh. , Nikulin R. E. 
Published: March 2023

Introduction. The incidence of postoperative ureteral strictures induced by iatrogenic injuries tends to increase. Reconstructive surgery involves open or laparoscopic intervention to repair strictures. However, both methods have their drawbacks. Surgical treating strictures of the lower third of the ureter can be effectively performed by means of robotic surgery.Aim. To determine outcomes of robot-assisted reconstructive surgery in treating postoperative strictures of the lower third of the ureter.Materials and methods. Five female patients with postoperative strictures of the lower third of the ureter underwent robot-assisted reconstructive surgery. Clinical and radiological outcomes in the long-term postoperative period were determined.Results and discussion. Two patients underwent simultaneous robot-assisted reconstructive surgery, namely, robot-assisted uretero-cysto-neoanastomosis on the right side and Boari operation on the left; robot-assisted Boari operation and isolation of post-traumatic uretero-vaginal fistula. In the remaining three cases, robot-assisted Boari operation and uretero-cysto-neoanastomosis with psoas-hitch were performed. No evidence of ureteral stricture in all cases was detected via multislice spiral CT (MSCT) urography in 3 months after surgery.Conclusion. At present, robot-assisted reconstructive surgery, being suitable for simultaneous surgery, is safe and effective whentreating postoperative strictures of the lower third of the ureter.
Veterinarians show resilience during COVID-19: challenges faced and successful coping strategies
Authors: Darby Brandy J. , Watkins Sarah T. , Haak Patricia P. , Ravi-Caldwell Nivedita , Bland Krista , Bissett Carolynn J. , Kryda Katharyn T. , Murphy Julia , Hungerford Laura , Russon Jody 
Published: March 2023

Abstract

OBJECTIVE
To identify challenges veterinarians faced during the COVID-19 pandemic, explore how they coped, identify coping strategies associated with greater resilience, and determine incentives and barriers to performing healthy coping behaviors.

SAMPLES
266 surveys completed by veterinarians in the Potomac region.

PROCEDURES
A cross-sectional survey was distributed electronically through veterinary medical boards and professional associations between June and September 2021.

RESULTS
Most survey responses came from veterinarians working in Maryland (128/266 [48%]) and Virginia (63/266 [24%]) who were predominantly white (186/266 [70%]), female (162/266 [61%]), and working in small-animal clinical practice (185/266 [70%]). The greatest workplace challenges experienced were increased workloads (195/266 [73%]) and reevaluating existing workflows (189/266 [71%]). Separation from loved ones (161/266 [61%]) was the greatest personal challenge. Of the veterinarians who completed the 10-point Connor-Davidson Resilience Scale (n = 219), which measures resilience on a scale from 0 (no resilience) to 40 (greatest resilience), the mean score was 29.6 (SD, 6.9), with a median of 30 (IQR = 10). Intrinsic factors most strongly associated with greater resilience were increasing age (P = .01) and later career stage (P = .002). Job satisfaction, autonomy, good work-life balance, and approach-focused coping strategies were positively associated with resilience. Overwhelmingly, the primary reported barrier to performing healthy coping behaviors was limited time to devote to self-care (177/266 [67%]).

CLINICAL RELEVANCE
A combination of individual approach-focused coping strategies and organizational interventions are crucial to support a resilient veterinary workforce.
The use of remote sensing data sources and GIS in fire protection planning in biebrza national Park, with special attention to non-forest ecosystems
Authors: Korzybski Damian , Mielcarek Miłosz , Szczygieł Ryszard , Kwiatkowski Mirosław , Piasecka Żaneta , Guderski Kacper , Kurpiewska Sylwia , Kuśnierz Hieronim 
Published: March 2023

ABSTRACT
In the spring of 2020, a large-scale fire destroyed 5,526 hectares of wetlands in Biebrza National Park. It was decided to modernize the park’s fire protection system. It proved necessary to develop rules for fire protection in large natural areas where non-forest communities predominate. A team of experts from the Forest Research Institute, the Fire Department, and the Biebrza National Park developed methods for fire protection in the park based on open, publicly available remote sensing data sources. The following methods were developed or modified and adapted to the conditions of the park: determination of fire danger, prediction of fire danger, modeling of fire development, determination of the network of fire access roads, determination of water supply points, including water withdrawal points for helicopters, detection of fires, functioning of the alarm and communication system, firebreaks, places of concentration of forces and resources, equipment for fire fighting, and taking preventive measures. The developed principles of fire protection in the Biebrza National Park, based on open remote sensing data and the technology of GIS, will enable the creation and operation of a system that will reduce the probability of fires in the future.
Nadia Boulanger and Her Role in Polish Music – in the Light of Zygmunt Mycielski’s Writings1
Authors: Bolesławska-Lewandowska Beata 
Published: March 2023

ABSTRACT

Nadia Boulanger and Her Role in Polish Music – in the Light of Zygmunt Mycielski–s Writings

Zygmunt Mycielski (1907–1987), a composer and writer on music, was one of the pupils of Nadia Boulanger (1887–1979). In his writings he often stressed the role which this eminent French teacher played in the development of a whole generation of Polish (and not only Polish) composers. Not only did Mycielski owe a lot to her personally, but he also clearly saw the significance of her teaching to the further fate of Polish music. He remained her friend, introduced her to Poland, and often mentioned both his education under her wings and the importance of her teaching. The article presents the figure and role of Nadia Boulanger in the light of the writings of Zygmunt Mycielski.
Mała litania uroczysta Karola Szymanowskiego
Authors: Boniecki Edward 
Published: March 2023

ABSTRACT

Karol Szymanowski’s Little Solemn Litany

Litany to the Virgin Mary

Two fragments op. 59 (1930–33) was the last vocal work in Karol Szymanowski’s oeuvre. Its writing marked the end of Szymanowski’s adventure with poetry, which had lasted throughout his activity as a composer. Composed to fragments of Jerzy Liebert’s poem with the same title, from the collection Gusła (1930), it was also a tribute to the young poet-who died prematurely of tuberculosis in 1931-paid by Szymanowski, who was moved by Liebert’s fate. Meeting Liebert became one of the most important spiritual experiences for the composer in the last few years of his life. What brought the two men close on the creative level was Franciscanism as striving for simplicity in art and their attitude to artistic craftsmanship, to the métier. Liebert, who experienced a fervent religious conversion and who introduced a new tone into Polish religious poetry, touched a religious chord in Szymanowski’s soul and helped him to extract more music from the reserves of his religiosity, apparently already exhausted in the opinion of the author of Stabat Mater. In doing so, he contributed to a revitalisation of the composer’s spiritual life and provoked him into carrying out an “examination of conscience”, as it were, which ultimately led to the writing of the Litany. A small masterpiece of vocal lyricism showing new perspectives in Szymanowski’s oeuvre and at the same time a prayer, like Gioacchino Rossini’s Petite messe solennelle.
Residential Real Estate as a Potential Hedge of Capital Against Inflation
Authors: Wolski Rafal 
Published: March 2023

ABSTRACTThere is a belief among investors that real estate is an excellent way to protect capital from depreciation due to inflation. Research does not provide a clear answer as to whether this investors’ belief is correct, but some approaches indicate that simple econometric methods are not able, especially in the short term, to clearly indicate the existence of a relationship between inflation and property prices (Fogler, 1984). The purpose of the study –was to find the relationship between residential real estate prices and inflation in the Polish economic conditions. Methodology of the study - the study used cointegration analysis with the Engle - Granger test. The research was carried out in the period from the first quarter of 2009 to the fourth quarter of 2021. The real estate hedonic indices calculated by NBP (National Bank of Poland) and the actual and forecasted inflation rates published by the GUS (Central Statistical Office) and the NBP (National Bank of Poland) were used in the research. The result - the analysis led to a negative verification of the research hypothesis, as it could not be proved that real estate prices were related to the level of inflation during the researched period. Originality/value - the study fills a gap in the Polish market regarding the analysis of the possibility of using real estate as a hedge against inflation. The research concerned only the Polish market, but this issue has not been taken up for years, also in mature economies.
ХОРЕОГРАФІЧНА ОСВІТА В УКРАЇНІ У СТРУКТУРІ СПЕЦІАЛІЗОВАНИХ НАВЧАЛЬНИХ ЗАКЛАДІВ 20-х рр. XX ст.
Authors: Благова Тетяна 
Published: March 2023

У статті досліджено основні набутки в організації, структурі, змістовому наповненні допрофесійної хореографічної підготовки, яка формувалася в освітній та культурно-мистецькій галузях у 20-х рр. XX ст. в Україні у закладах різного функційного призначення: виробничих студіях, приватних хореографічних профшколах, профільних курсах, клубах, танцкласах, творчих майстернях, просвітницьких організаціях. Вони охоплювали різновікову аудиторію танцюристів і забезпечували первинну хореографічну підготовку – базові виконавські уміння із різних видів танцювального мистецтва, необхідні для подальшого професійного хореографічного навчання.