bluuebunny/crossref_metadata_2025_split huggingface dataset:
Existence of nonconstant CR-holomorphic functions of polynomial growth in Sasakian manifolds
Authors: Chang Shu-Cheng , Han Yingbo , Li Nan , Lin Chien 
Published: August 2023

Abstract
We show that there exists a nonconstant CR-holomorphic function of polynomial growth in a complete noncompact Sasakian manifold of nonnegative pseudohermitian bisectional curvature with the CR maximal volume growth property.
This is the very first step toward the CR analogue of the Yau uniformization conjecture which states that any complete noncompact Sasakian manifold of positive pseudohermitian bisectional curvature is CR biholomorphic to the standard Heisenberg group.
More precisely, we first construct CR-holomorphic functions with controlled growth in a sequence of exhaustion domains in Sasakian manifolds by applying the Cheeger–Colding theory.
Secondly, via the CR analogue of a tangent cone at infinity and the three-circle theorem, we are able to take the subsequence to obtain a nonconstant CR-holomorphic function of polynomial growth.
Vom Zeichen der Bewunderung zum Symbol der Position – Brecht mit der Legende von der Entstehung des

Daodejing
Authors: Jing Jing , Li Changke 
Published: August 2023

Zusammenfassung
Brecht hatte sich schon früh mit dem altchinesischen Denker Laotse beschäftigt und war begeistert. Sein bislang noch wenig behandelter Zeitungstext Die höflichen Chinesen erzählt die Legende von der Entstehung des Daodejing nach und ist das erste prosaische Zeichen der Bewunderung: Brecht plädierte implizit für ein Leben nach Laotses Lehre. Dreizehn Jahre später hatte Brecht die Legende von der Entstehung des Daodejing wieder aufgenommen, um sie in das Gedicht Die Legende von der Entstehung des Buches Taoteking auf dem Weg des Laotse in die Emigration umzugestalten. Das Exil veränderte Brechts Selbstbewusstsein. Brecht aktualisierte seine Beziehung zu Laotse, indem er sein Selbstbildnis in Laotses Schicksal auftauchen ließ. Auf diese Weise der Aktualisierung wird Die Legende von der Entstehung des Buches Taoteking auf dem Weg des Laotse in die Emigration politisch.
Why we do not need demonstrative proof for God’s existence to know that God exists
Authors: Novaković Aleksandar 
Published: August 2023

Abstract
As a counterpoint to demonstrative proofs in metaphysics, Robert Nozick presented the case for God’s existence based on the value of personal experiences. Personal experiences shape one’s life, but this is even more evident with extraordinary experiences, such can be religious ones. In the next step, says the argument, if those experiences can be explained only by invoking the concept of the Supreme Being, then God exists. The second step mirrors scientific explanation constituting what Nozick calls the “argument to the best explanation.” The argument is set against the background of Nozick’s methodology which rejects demonstrative proofs in metaphysics. Its purpose is threefold. It aims to establish a certain sort of experience (religious/spiritual) as a legitimate basis for the argumentation; it aims to show that it is not philosophically blasphemous to explain such experiences by introducing a concept of divinity. Finally, it seeks to showcase the non-dogmatic, investigative nature of the argument. By exploring the merits of Nozick’s proposal, I will try to elucidate all three components, which should pave the way for a broader discussion on the role of non-demonstrative arguments in metaphysics.
Subacute thyroiditis following Mpox infection in a patient with human immunodeficiency virus
Authors: Ssemmondo Emmanuel , Idris Mohamed Akasha , Mawer Damian , Easom Nicholas , Thow Jonathan 
Published: August 2023

Summary
Mpox (MPX) formerly known as monkeypox was declared a public health emergency of international concern, following an outbreak that commenced in May 2022. We report a case of subacute thyroiditis following MPX infection. To our knowledge, it is the first documented incidence of this complication in humans. A 51-year-old male, with a well-controlled human immunodeficiency virus (HIV) infection on antiretroviral therapy, was reviewed 3 weeks after a positive test for MPX. The acute skin lesions and initial systemic symptoms had resolved, but he described significant neck discomfort, fatigue, weight loss and night sweats. Blood tests showed a raised C-reactive protein, free T4 and suppressed thyroid-stimulating hormone. His thyroid antibodies were negative. He was treated initially with carbimazole and propranolol, pending exclusion of any other intercurrent infection. A chest radiograph was normal; blood cultures and a combined nose and throat swab for respiratory virus PCR testing were negative. Following this, he commenced a 2-week course of prednisolone; his symptoms resolved completely within 24 h of starting. He subsequently developed hypothyroidism, which was treated with levothyroxine. The clinical features, abnormal thyroid function, raised CRP and negative thyroid antibodies 3 weeks post-MPX positive test was consistent with viral subacute thyroiditis. This case demonstrates that, as described following other viral infections, MPX can cause subacute thyroiditis, which follows a similar course to the classic form of subacute thyroiditis. Clinicians should be aware of this potential endocrine complication when attending to patients with MPX.

Learning points

Subacute thyroiditis can present following mpox virus infection.

Its course is similar to the classic form of subacute thyroiditis and steroids are effective.

It is important to exclude other concurrent infections prior to starting steroids, especially for patients who are immunosuppressed or in other high-risk groups.
La indagación de fenómenos históricos a través del uso de recursos digitales abiertos: una experiencia en educación secundaria en Ponedera (Atlántico, Colombia)
Authors: Alvarado Laura Milena , Baldovino Gómez Rober 
Published: August 2023

Este artículo busca presentar el resultado de un trabajo de investigación a través del cual se propuso desarrollar la habilidad investigativa de la indagación de fenómenos históricos a través del uso de recursos digitales abiertos con un grupo de 21 estudiantes de sexto grado de la Institución Educativa Técnica Comercial de Ponedera Atlántico. Evidenciando que existe una problemática en cuanto al proceso de indagación e investigación en ciencias sociales que realizan los estudiantes. Se hace la fundamentación teórica y conceptual a partir de un modelo pedagógico constructivista y de la indagación como habilidad investigativa. La investigación se desarrolló bajo un método cualitativo, etnográfico El resultado del instrumento de caracterización aplicado a la muestra de estudiantes permitió evidenciar el desconocimiento que ellos tenían acerca de la indagación. Sin embargo, el instrumento final demostró que, a través del proyecto desarrollado, los estudiantes lograron fortalecer el proceso de indagación de fenómenos históricos, dinamizado por el uso de Recursos Digitales Abiertos. El desarrollo de la investigación permitió determinar el nivel de indagación de un fenómeno histórico por la capacidad que desarrollaron los estudiantes para identificar y reconocer algunos aspectos fundamentales de un fenómeno histórico y poderlo presentar de forma lúdica a sus demás compañeros, esto a través de un trabajo autónomo y colaborativo que se dio entre los estudiantes.
Investigación como estrategia pedagógica para la construcción de saber ambiental en el aula
Authors: Villamil Padilla Mayra Andrea 
Published: August 2023

El artículo busca identificar los saberes que construyeron los estudiantes del curso 902 en la Institución Educativa Distrital Gonzalo Arango, ubicada en Bogotá, Colombia, durante un proceso de Investigación como estrategia pedagógica en educación ambiental respecto al humedal Tibabuyes en la localidad de Suba. Para esto, se tomaron los planteamientos epistemológico-investigativos de la sistematización de experiencias, los cuales de acuerdo con Jara (1994) implican metodológicamente las etapas de: recuperación del proceso vivido, análisis del proceso y establecimiento de los puntos de llegada.
Así pues, en el desarrollo esta experiencia educativa que se ubicó en el horizonte crítico de la educación popular, los estudiantes dieron cuenta de una complejización de sus perspectivas respecto a la relación hombre-naturaleza, lo que promovió nuevas maneras para situarse en el mundo de forma crítica y ética frente a la crisis ambiental . De tal manera se asumió la actividad investigativa escolar como una propuesta alterna a la enseñanza tradicional que favoreció la consolidación de un proceso de aprendizaje tanto de información ambiental, como de habillidades investigativas y de pensamiento histórico.
Suitability of pearl millet (Pennisetum glaucum (L.) R. Br.) and sorghum (Sorghum bicolor (L.) Moench) based food products for diabetics
Authors: Sewak A. , Singla N. , Javed M. , Gill G.S. 
Published: August 2023

AbstractIn the study, suitability of porridge, bun, and salad prepared from processed pearl millet FBC16 and sorghum PSC4 had been evaluated organoleptically by a panel of semi-trained judges and 25 non-insulin dependent diabetes mellitus subjects. Organoleptically, germinated pearl millet was found to be more suitable for porridge (50%) and salad (100%), while puffed sorghum was best suitable for bun (15%) preparation. Prepared porridge had significantly (P ≤ 0.05) higher protein (16.9%) and total phenols (178.8 mg GAE/100 g) contents and antioxidant capacity (1,036 mg TE/100 g) than control. The dietary fibre and in vitro starch digestibility of composite porridge and bun increased significantly (P ≤ 0.05). Most acceptable composition of porridge, bun, and salad had low glycaemic index (17.64–26.79) and medium to low glycaemic load (8.82–13.40). Suitability of pearl millet and sorghum using appropriate processing techniques (germination and puffing) is recommended for preparation of indigenous food products especially for diabetics.
DISTAL THIRD TIBIAL FRACTURE SURGERY WITH FIBULAR FIXATION: IS IT NECESSARY FOR UNION AND ALIGNMENT?
Authors: TURGUT Necmettin , İNCE Ahmet , UNAL Meric 
Published: August 2023

Objective
The management of distal third tibial fractures remain
controversial. The aim of the present study was to
evaluate whether concurrent fibular fixation changes
union rates and aids in alignment in the case of distal
third tibia fractures.
Material and Method
The study included 106 distal third tibia fracture
operation cases in which the distance from the fracture
to the plafond was between 3-12 cm at a single centre
between January 2016 and June 2020. The patients
were divided into three groups according to the status
of the fibula: Group 1 (without fibular fixation with
the presence of a fibula fracture, 47 cases), Group
2 (concurrent fibular fixation with the presence of a
fibular fracture, 38 cases) and Group 3 (intact fibula,
21 cases). All fibular fixation surgeries were performed
with locked plates (LCP) and tibial fixation with either
LCP or intramedullary nailing (IMN). The primary
outcome measures were union and alignment. Age,
gender, AO classification, fibula fracture location,
presence of an open fracture, implant type and time
delay for surgery were also assessed.
Results
None of the variables except the presence of an open
fracture was significant for the union rates or alignment.
The union rate was significantly less if there was an
open fracture in the concurrent fibular fixation group
(p
Surviving in the Digital Space: Digital Literacy of Syrian Immigrants in Turkey
Authors: NARMANLIOĞLU Haldun , BAYRAKCI Serkan 
Published: August 2023

Turkey is one of the countries hosting the largest number of Syrian immigrants in the world. Integration
of Syrian immigrants is one of the problems Turkey has to overcome. Many studies around the world
show that digital communication tools can be used effectively by immigrants in many integration processes
such as language learning, learning about culture and socialization. In this study, which was carried out
as a project of The Scientific And Technological Research Council of Türkiye (TÜBİTAK), we aimed to
determine the digital literacy levels of Syrian immigrants, which is a prerequisite for their integration by
using digital tools. We applied a digital literacy scale adapted to Arabic to Syrian immigrants. The study,
which was conducted both online and face-to-face, investigated the general digital literacy status of Syrian
immigrants and their digital literacy levels according to variables such as gender, age, education level,
income level, access to the internet, and Turkish citizenship status. Both at the general level and at the level
of all variables, the digital literacy of Syrian immigrants was determined to be “Below Average / Weak”.
Especially in European countries, public policies have started to be established to increase the digital literacy
levels of isolated groups such as immigrants. In order to overcome the immigrant integration problem in
Turkey through digital communication, public policies should be established to increase the digital literacy
levels of immigrants.
Dissection of novel genetic regions and superior alleles related to high grain number per spike in a new wheat-Agropyron germplasm Pubing3228
Authors: Wang Jiansheng , Wang Erwei , Cheng Shiping , Ma Aichu 
Published: August 2023

Abstract
Agropyron cristatum (L.) can be used as a valuable gene resource for broadening the genetic basis of common wheat in breeding programs. Pubing3228 is a new elite wheat-Agropyron hybrid germplasm that possesses many desirable agronomical traits, includingthe grain number per spike (GNS), the main yield component. Uncovering the genetic architecture of GNS in Pubing3228 is important for increasing wheat yield through molecular assisted breeding. In the present study, genetic regions and alleles associated with high GNS from Pubing3228 were analyzed using a recombination inbred line (RIL) population derived from the cross between Pubing3228 and Jing4839. In total, 75 QTLs were identified for GNS. These QTLs mapped to 21 chromosomes (i.e.,all except for 5B and 6A) and explained 3.30–17.17% of the total phenotypic variation. Five QTLs (QGns.wa-1D, QGns.wa-5A, QGns.wa-7D.1, QGns.wa-7D.2, and QGns.wa-7D.3) explained more than 10% of the phenotypic variation in at least two environments. Pubing3228 contributed 94.67% of the total number of QTLs associated with GNS. Candidate gene analysis was conducted for the stable QTLs, and 11 candidate genes were obtained for GNS. Among these 11 genes, a senescence-associated protein gene (TraesCS7D01G148000) linked with the most significant single nucleotide polymorphism (SNP) AX-108748734 on chromosome 7D was relevant to remobilizing the nutrients from the senescing tissues to the developing seeds. The findings of this study will not only provide new insights into the genetic mechanism of high GNS of Pubing3228 but willalso be useful for marker-assisted selection for yield improvement in breeding practice.
Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors
Authors: Stockner Thomas , Gradisch Ralph , Schlögl Katharina , Lazzarin Erika , Niello Marco , Maier Julian , Mayer Felix , Silva Leticia Alves da , Skopec Sophie , Blakely Randy , Sitte Harald , Mihovilovic Marko 
Published: August 2023

Abstract
The presynaptic serotonin (5HT) transporter (SERT) clears extracellular 5HT following vesicular release to ensure temporal and spatial regulation of serotonergic signalling and neurotransmitter homeostasis. Clinically approved drugs used for the treatment of neurobehavioral disorders, including depression, anxiety, and obsessive-compulsive disorder that target SERT trap the transporter in the outward-open state thus blocking the transport cycle. In contrast, illicit drugs of abuse like amphetamines reverses SERT directionality, thereby causing 5HT efflux. Both result in an increase of extracellular 5HT levels. Stoichiometry of the transport cycle has been described by kinetic schemes, whereas the structures of the main conformations provide only static coordinates of molecular features of the process. By combining in-silico molecular dynamics modelling approaches with in-vitro and ex-vivo biochemical experiments and making use of a homologous series of 5HT analogues, we uncovered the essential coupling mechanism between the substrate and the transporter triggering the uptake process. The free energy calculations showed that only scaffold-bound substrates can correctly close the extracellular gate. Attractive forces acting on the bundle domain through long-range electrostatic interactions tilt the bundle domain towards the scaffold domain. The associated spatial requirements define substrate and inhibitor properties, enabling new possibilities for rational drug design approaches.
A Survey of Ownership and Utilization of Insecticide Treated Nets (ITNs) Among Pregnant Women Attending ANC Clinic
Authors: Diebieri Maximous , Alhassan Barikisu Ategtoore , Ayamba Monica Salamatu , Antwi Faustina Mensah 
Published: August 2023

Abstract
This study sought to assess the ownership and utilization of insecticide treated nets among pregnant women attending antenatal care clinic A cross-sectional study design was adopted to conduct the study METHODS: A structured questionnaire was used to collect data from 185 pregnant women. The data were presented by means of descriptive statistics. Findings showed that 93.5% of the pregnant women owned at least an ITN with 90.3% owning more than one ITN prior to the survey. However, 6.0% of the pregnant women slept under ITN the night before the survey. A combination of personal, household, and institutional factors accounted for the poor usage of the ITNs
Left atrial dissection : An unique complication of mitral valve surgery
Authors: Aljasem Hazem , Ali-Ghosh Hani , Ohri Sunil 
Published: August 2023

Abstract
Background: Left atrial dissection is an unique but an extremely rare complication associated with cardiac surgery especially mitral valve surgery.
Case Presentation: Here we presented a case report of a 76-year old lady who had mitral valve surgery complicated with left atrial dissection managed surgically. Interestingly, we proposed a new classification of left atrial dissection which could guide the surgeon in the management of this complication.
Conclusions: left atrial dissection might be a lethal complication associated with mitral surgery and can be managed surgically and non surgically depending on the clinical courser and haemodynamic state. The new proposal can help the surgeons to put the management plan.
Pan-cancer single-cell RNA sequencing analysis refines multi-origin monocyte and macrophage lineages
Authors: Park Woong-Yang , Nguyen Truc , Park Hyun Jung , Lee Dong-Sup , Shah Nameeta , Mandzhieva Bayrta 
Published: August 2023

Abstract
Tumor-associated macrophages (TAMs) play vital roles in cancer tissue homeostasis, immunosuppression, and angiogenesis in the tumor microenvironment. Here, we utilize single-cell transcriptomics to present an atlas of healthy and pan-cancer myeloid cell populations, revealing their remarkable heterogeneity. We uncovered the dual origins of TAMs including C1QC+ TAMs derived from resident tissue macrophages, and SPP1+ TAMs and ISG15+ TAMs derived from blood monocytic populations. The differentiation of immature myeloid-derived suppressor cells (MDSCs) to TAMs is also elucidated, with THBS1+ MDSCs and SPP1+ TAMs shown to play critical roles in immunosuppression and angiogenesis and are associated with worse survival in many cancer types. Additionally, this study reveals the presence of a monocytic subtype, BAG3+ Mono, that undergoes cellular stress during the differentiation into M2 macrophages and is linked to poor survival rates in multiple cancer types and inferior response to immune-checkpoint blockade (ICB) therapy. Overall, this study offers critical perspectives into the intricate interplay between various monocyte-macrophage cell subtypes.
Construction of an immune prediction model for osteosarcoma based on coagulation-related genes
Authors: Jiang Ye , Wang Xinyu , Li Yang , Lu Shiyuan , Chen Chunzheng , Lin Liangxin , Yang Qifan , Wang Hongbo , Zhu Dong 
Published: August 2023

Abstract

Objectives
The prognostic outcome of osteosarcoma, as the most common primary malignancy in children and adolescents, has not improved better with the development of modern medical care, and the aim of this study was to investigate the role of the coagulation system in the diagnosis and development of osteosarcoma.
Methods
TRGET and GEO databases were used to acquire clinical information and matching RNA data from osteosarcoma patients. To find novel molecular groupings based on coagulation systems, shared clustering was used. TIMER, SSGSEA, CIBERSORT, QUANTISEQ, XCELL, EPIC, and MCPCOUNTER analyses were used to identify the immunological status of the identified subgroups and tumor immune microenvironment (TIME). To understand the underlying processes, functional studies such as GO, KEGG, and protein-protein interaction (PPI) network analysis were used. Prognostic risk models were built using the LASSO technique and multivariate Cox regression analysis.
Results
The survival rates of the two molecular groupings were considerably different. large immunological scores, poor tumor purity, a large number of immune infiltrating cells, and a reasonably good immune status were all related with a better prognosis. According to GO and KEGG analyses, DEGs between the two groupings were primarily enriched in immunological and extracellular matrix-related pathways. Risk models based on coagulation system-related genes (CRGs) show promise in predicting osteosarcoma survival. A nomogram that combines risk models and clinical data may reliably predict the prognosis of individuals with osteosarcoma.
Conclusion
In patients with osteosarcoma, the expression of genes associated to the coagulation system is strongly related to the immunological milieu and can be utilized to correctly predict the prognosis of osteosarcoma.
Neuroprotective Role of Metformin in a Model of Cerebelar Ataxia
Authors: Atella Tainá Correa , Medina Jorge Mansur , Atella Georgia Correa , Allodi Silvana , Kluck George E. G. 
Published: August 2023

Abstract
Cerebellar ataxia is a heterogeneous group of neural disorders clinically characterized by cerebellar dysfunction. The diagnosis of patients with progressive cerebellar ataxia is complex due to the direct correlation with other neuron diseases. Although there is still no cure for this pathological condition, some metabolic, hereditary, inflammatory, and immunological factors affecting cerebellar ataxia are being studied and which may become therapeutic targets. Advances in studying the neuroanatomy, pathophysiology, and molecular biology of the cerebellum contributes to better understand the mechanisms behind the development of this disorder. In this study, we analyzed the neuromodulatory role of the AMP-activated protein kinase (AMPK) on cerebellar ataxia induced by the neurotoxin 3-acetylpyridine (3-AP) in brain stem and cerebellum, after pre-treatment with metformin, a pharmacological indirect activator of AMPK. The results shown here suggest that AMPK activation in the brain stem and cerebellum leads to a significant reduction in neuroinflammation in these regions. AMPK was able to restore the changes in fatty acid composition and pro-inflammatory cytokines caused by 3-AP, suggesting that the action of AMPK seems to result in a possible neuroprotection on the cerebellar ataxia model.