bluuebunny/crossref_metadata_2025_split huggingface dataset:
NVS-ZP7-4 inhibits hepatocellular carcinoma tumorigenesis and promotes apoptosis via PI3K/AKT signaling
Authors: Tong Qing , Yan Dong , Cao Yan , Dong Xiaogang , Abula Yimamumaimaitijiang , Yang Huan , Kong Panpan , Yi Mingyu 
Published: July 2023

AbstractNVS-ZP7-4 was identified as a novel chemical reagent targeting the zinc input protein ZIP7, which accounts for the zinc surge from the apparatus to the cytoplasm. Since zinc dysregulation is related to multiple diseases, in this study, we aimed to identify the anti-tumor effects of NVS-ZP7-4 and explore the molecular mechanisms of NVS-ZP7-4 in hepatocellular carcinoma (HCC) progression. We found that NVS-ZP7-4 inhibited cell viability, caused cell cycle arrest, induced apoptosis, and inhibited the proliferation, migration, and invasion of HCCLM3 and Huh7 cells. We further investigated the inhibited activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway was involved in the antitumor effect of NVS-ZP7-4 in HCC. Furthermore, NVS-ZP7-4 inhibited HCC tumor growth in vivo. The present study demonstrated that NVS-ZP7-4 is a promising therapeutic target for HCC by regulating PI3K/AKT signaling.
Role of EEG and MRI brain in the diagnosis of unprovoked seizures in children in a tertiary care centre
Authors: Priyadarshini Theetla , Pradheep Kumar Kokku , CH Sravanthi , Chaitanya Jyothi Ravula 
Published: July 2023

Seizure disorders are a major public health problem in a developing country like India. Epilepsy characterized by recurrent unprovoked seizures is a common heterogeneous neurological problem in children that exerts a significant medical, physical, psychological, social, and economic challenge. This study evaluated the importance of the available diagnostic modalities, EEG and MRI, which could influence the management, prognosis and recurrence of unprovoked seizures.
The aims and objectives: To determine the role of Electroencephalography and MRI BRAIN in evaluating children presenting with unprovoked seizures.
Methodology: The present study was a hospital-based observational study carried out during the period of January 2021 to December 2021 of 70 children who presented with unprovoked seizures to the Department of Paediatrics, Niloufer Hospital, Hyderabad.
Results: Among the 70 children who were investigated, EEG showed abnormal findings in 45 (64.29 %) cases. Out of these, the majority of 32 (45.71 %) cases had generalized seizures, and 13 (18.57 %) cases were focal seizures. MRI showed abnormal findings in 30 (42.86 %) cases, and an equal percentage of cases, 15 (21.43 %) of generalized seizures and focal seizures, were having abnormal MRI findings out of the 30 cases with abnormal MRI findings. But, when studied among the individual seizure subtype, a major proportion of focal seizure (68.18 %) cases out of 22 focal seizures had abnormal MRI findings when compared to 31.25 % of generalized seizure cases out of 48 generalized seizure cases with abnormal MRI findings.
Conclusion: MRI can identify most of the structural brain abnormalities, and EEG is useful to clearly identify the region of the epileptogenic foci. Therefore, EEG and MRI were useful in identifying a possible cause for unprovoked seizures in children
The largest Chinese cohort study indicates homologous recombination pathway gene mutations as another major genetic risk factor for colorectal cancer with heterogeneous clinical phenotypes
Authors: Xu Yun , Liu Kai , Li Cong , Li Minghan , Liu Fangqi , Zhou Xiaoyan , Sun Menghong , Ranganathan Megha , Zhang Liying , Wang Sheng , Hu Xin , Xu Ye 
Published: July 2023

Abstract
Background: Colorectal cancer (CRC) is one of the most common malignancies globally with estimated 1.87 million new cases annually. Genetic factors were associated with over 30% of CRC incidence. However, the mutations in CRC-susceptibility genes recommended by the National Comprehensive Cancer Network (NCCN) guidelines accounted for only 5-10% of CRC cases, suggesting a large proportion of CRC-susceptibility genes remain unknown. As previous works on hereditary CRC were largely designed to analyze germline mutations in patients with a single category of genetic high-risk factor, this study aims to explore the genetic mutations underlying five categories of genetic high-risk factors in clinic.
Methods: From January 2015 to December 2018, 2181 patients from a cohort of 8270 consecutive CRC cases were retrospectively enrolled, covering five categories of genetic high-risk factors. Their germline mutations under each category were detected and analyzed in association with CRC susceptibility, clinical phenotypes, and prognoses.
Results:In total 462 pathogenic/likely pathogenic genetic variants were detected in 19.3% CRC patients enrolled. Mutations in the mismatch repair (MMR) genes were identified in 9.1% patients, most prevalent across all high-risk groups. Mutations in homologous recombination (HR) pathway genes were detected in 6.5% patients, which were mostly penetrated in early onset, family cancer history and extra-colonic cancer risk groups. HR pathway gene mutations, including BARD1, RAD50 and ATM, were associated with an increased risk of CRC in the cohort with an odds ratio of 2.8, 3.1 and 3.1-fold, respectively. CRC patients carrying different genetic mutations manifested heterogeneous phenotypes in clinicopathology and long-term prognoses, for which Lynch Syndrome demonstrated better prognoses than other groups, including those with HR pathway mutations.
Conclusions: This largest Chinese cohort study of high-risk hereditary CRC is the first to cover five categories of genetic high-risk factors, which greatly expanded the list of CRC-susceptibility mutations. In contrast to the MMR mutations of Lynch syndrome, the study reveals for the first time at population level that carriers of mutations in the HR pathway genes are significantly susceptible to CRC, implicating HR pathway gene mutations as another major contributor for increased risk of developing CRC.
Trial registration: Retrospectively registered.
Hiperplasia papilar endotelial intravascular en un dedo de la mano
Authors: García-Jiménez Antonio 
Published: July 2023

Se presenta un caso de hiperplasia papilar endotelial intravascular, una lesión vascular benigna no neoplásica poco frecuente, también conocida como tumor de Masson, que se localizaba en la cara palmar de la falange distal del dedo pulgar de la mano izquierda de un hombre de 60 años. El diagnóstico solo pudo establecerse tras su exéresis mediante el estudio histológico de la lesión, pues los estudios de imagen previos mediante resonancia magnética no fueron concluyentes.
A pesar de que el pronóstico de la hiperplasia papilar endotelial intravascular es excelente, es importante establecer un diagnóstico diferencial de otras patologías que requieren intervenciones terapéuticas más extensivas.
PEDAGOGICAL CONCEPT OF AN ELEMENTARY SCHOOL TEACHER IN THE TVER TEACHER'S SCHOOL OF P.P. MAKSIMOVICH
Authors: Ильина Т.А. 
Published: July 2023

Анализируется педагогическая концепция учителя начальной школы, теоретически сформированная в трудах первых педагогов Тверской женской учительской школы им. П.П. Максимовича и практически воплощаемая в жизнь на протяжении всех лет работы этой школы (1870- 1919). Подробно рассматриваются личностные качества будущих учителей, которые должны были быть сформированы в процессе обучения.
The pedagogical concept of an elementary school teacher is analyzed, theoretically formed in the works of the first teachers of the P.P. Maksimovich Tver Women's Teacher's School and practically implemented throughout all the years of work of this school (1870-1919). The personal qualities of future teachers, which should have been formed in the learning process, are considered in detail.
СРАВНИТЕЛЬНЫЙ АНАЛИЗ МЕТОДОВ ДЕРЕВЬЕВ РЕШЕНИЙ И НЕЙРОННЫХ СЕТЕЙ В ЗАДАЧЕ КЛАССИФИКАЦИИ КРЕДИТНЫХ ОРГАНИЗАЦИЙ
Authors: Акишина Е. П. , Иванов В. В. , Крянев А. В. , Приказчикова А. С. 
Published: July 2023

В последние годы деревья решений и нейронные сети широко применяются в задачах компьютерного зрения, таких как распознавание объектов, классификация текстов, распознавание жестов, обнаружение спама, семантическая сегментация и кластеризация данных. В статье рассматривается применение методов деревьев решений и искусственных нейронных сетей в задаче классификации кредитных организаций как объектов экономической безопасности. Представлены результаты анализа данных о деятельности кредитных организаций с использованием разных методов деревьев решений: C5, CHAID, C&R и QUEST, а также нейронных сетей. Наивысшая общая точность классификации анализируемых объектов была достигнута с помощью алгоритма деревьев решений С5 и составила 81 %. Общая точность классификации при применении алгоритма CHAID составила 68 %, алгоритма C&R – 71 %, алгоритма QUEST – 66 %. На основании результатов алгоритма C5 сгенерирован набор правил для определения принадлежности банка к определенному классу. Согласно методам деревьев решений и нейронным сетям были отобраны наиболее информативные показатели деятельности кредитных организаций с точки зрения их разбиения на два класса: благонадежные и высоко-рисковые.
Mediating Role of Employee Engagement on Person-Organization Fit and Turnover Intention in Indonesia
Authors: Margaretha Meily , Zaniarti Sri , Indrawan Dava 
Published: July 2023

Purpose: The aim of this study is to examine the effect of person-organizational fit (PO-fit) on turnover intention. It also analyzes employees' engagement (EE) as a variable that mediates the relationship between the two variables.

Theoretical framework: An organization tends not to avoid the problem of turnover intention when employees voluntarily submit resignations letter. Therefore, all companies need to understand the factors such as person-organization fit (PO-fit) that can affect this turnover. Previous studies failed to fully show a negative relationship between PO-fit and turnover intention. Theoretically, there is an increased engagement when employees have values that suit the organization's own. It ultimately increases individuals' intention to remain in the company where they work.

Design/Methodology/Approach: The respondents of this study were 366 employees from several big cities on Java island in Indonesia. The sampling criteria were those that had worked for at least 1 year. This survey was conducted using internet-based questionnaires and data were analyzed by testing the validity and reliability, as well as the hypotheses.

Findings: The results showed a significant relationship between PO-fit and turnover intention while examining the total 366 employees in Indonesia. Furthermore, all hypotheses are supported because there was an indirect effect of EE on turnover intention.

Research, practical & social implications: This study has several implications including managers being required to ensure that organizational culture is conveyed to increase the PO-fit value between employees and their organization.

Originality/Value: The research focuses on studying examine the effect of person-organizational fit (PO-fit) on turnover intention. Moreover, only a few studies that discuss employee engagement to be a mediator of PO-fit and turnover intention. Therefore, this study examines the EE role as a mediating variable in explaining the relationship between PO-fit and employee turnover in Indonesia.
The Analysis of Locutionary Speech Acts on YouTube Channel Arisa Nur Aini
Authors: Sari Ismi Aulia , Setyowati Shinta Anggraeni , Kusuma Marchell Teja , Buono Setiya Adi , Utomo Asep Purwo Yudi 
Published: July 2023

Locution is a speech act that exists in pragmatic studies, locution itself can be interpreted as a speech act that states something where the action produces a meaningful expression. The other name of this speech act is the act of saying something. In everyday life, we definitely find locutionary speech acts, one of which is in the form of Indonesian language learning videos on YouTube. Therefore, researchers want to examine more deeply about the locutionary speech act. This research is focused on one of the fields of pragmatics, namely speech acts. The analysis was conducted on learning videos on Arisa Nur Aini's YouTube channel, namely on the playlist of Indonesian Language Materials for Grade 11 SMA semester 1 which was motivated by the discovery of the use of various types of locutionary speech acts in the sentence. The data source used is the Indonesian learning video of Grade 11 Material. The data used is in the form of utterances in the learning video which are included in the type of locutionary speech acts. The research method used in this research is a qualitative descriptive method which uses data collection techniques in the form of listening and recording techniques. The purpose of this study is to determine the types of locutionary speech acts in playlists of Indonesian Language Materials for Grade 11 SMA semester 1 on Arisa Nur Aini's youtube channel. From the analysis, it is found that the types of locutionary speech acts in the form of interrogative sentences consisting of 7 utterances, declarative sentences consisting of 20 utterances, and imperative locutionary speech acts consisting of 7 utterances. With this analysis, the readers are expected to be able to interpret and classify the types of locutionary speech acts. Keywords: lokusi, pragmatic, arisa, youtube, sma
Challenges and scope of movement disorder surgery in Nepal
Authors: Shrestha Resha , Gurung Pritam , Pant Basant 
Published: July 2023

Movement disorders (MD) are clinical syndromes with either excess or paucity of voluntary or involuntary movements without weakness or spasticity. Hypokinetic MD includes primary and secondary Parkinsons disease and Parkinsons syndrome and hyperkinetc MD includes dystonia, tremors, choreas and dyskinesias. Although medical treatment is the mainstay of treatment modality, in selected cases surgical treatment is a safe option
SRI LANKAN STOCK MARKET VOLATILITY ANALYSIS: AN ARMA- GARCH APPROACH
Authors: Samarawickrama I.D.W.  , Pallegedara A.  
Published: July 2023

Beyond its role in capital generation, a stock market is emulated as a facet in economic development indication. Sri Lankan stock market, the Colombo Stock Exchange (CSE) is a languidly developing market known for instability and periodical fluctuations increasing the volatility risk for the investors. Toward market development, it is imperative in attracting and retaining long term investors. Thus, the study aimed to identify the dynamics of the CSE through volatility estimation of the Sri Lankan stock market during a high volatile period. Further, the use of ARMA-GARCH models aims to contribute to the local empirical studies on the applicability of ARMA-GARCH models in the Sri Lankan context.
The study used the daily closing prices of the All-Share-Price Index (ASPI) from January 2018 to December 2022 in log return volatility. Owing to the non-normality and serial dependence conditions inherent in the data, the study developed an ARMA (2,2) mean equation and separate volatility equation applying symmetric models of GARCH, and TGARCH and asymmetric GARCH models of EGARCH, and GJR-GARCH.
The study findings identified that asymmetric GARCH models are more reliable in volatility estimation and forecasting. Further, ASPI indicated a leverage effect where negative information caused idiosyncratic volatility.
Keywords: ARMA-GARCH, GARCH, Leverage Effect, Stock Markets, Volatility
Caracterização do perfil epidemiológico e clínico dos casos de arboviroses urbanas transmitidas pelo Aedes no Brasil, nos anos de 2017 a 2021
Authors: Rios Matheus Marinho , Ferreira Milene Silveira , Azevedo Raimunda do Socorro da Silva , Silva Maria Inês Caricchio da , Moraes Junior Rudival Faial de , Silva Mikelly Santos Coutinho da , Vasconcelos Pedro Fernando da Costa , Martins Lívia Caricio 
Published: July 2023

As infecções por arbovírus aumentaram dramaticamente durante os últimos anos. A sintomatologia semelhante na fase inicial da doença dificulta o diagnóstico diferencial e o manejo clínico. Esse estudo descreve o perfil epidemiológico e clínico dos casos de arboviroses urbanas transmitidas por Aedes aegypti no Brasil no período de 2017 a 2021. Foram analisados 1.145 casos humanos disponíveis no Sistema de Gerenciador de Ambiente Laboratorial (GAL) positivos para os vírus Chikungunya (CHIKV) (741/64,71%), vírus Dengue (DENV) (381/33,27%) e vírus Zika (ZIKV) (23/2%). As informações clínicas e epidemiológicas foram obtidas a partir das fichas de investigação epidemiológicas do Sistema de Informação de Agravos de Notificação (SINAN). A maioria dos infectados eram do sexo feminino (63%), pardos (31%) e faixa etária de 31 a 40 anos de idade. Os sintomas mais relatados foram febre (90%), artralgia intensa (67,3%), cefaleia (53,2%), mialgia (52,8%) e exantema (50%). Durante a fase aguda (D0 a D6) foi observado que os indivíduos infectados com DENV apresentavam sinais/sintomas mais elevados dos que os infectados com o ZIKV e CHIKV. Na fase de convalescência (D7 a >D15), os sinais/sintomas dos infectados com CHIKV elevaram-se e os com DENV e ZIKV declinaram. Quando se considerou a avaliação dos sinais/sintomas em uma proporção aumentada (≥10%) foram observados entre os infectados com o CHIKV os sinais/sintomas apresentaram-se em uma proporção aumentada mais tardiamente (D6 a >D15). A caracterização do perfil clínico das arboviroses pode direcionar o diagnóstico clínico diferencial, bem como, correlacionar os aspectos epidemiológicos com a evolução da doença.
Postoperative dysesthesia after PVCR without anterior support applied in Yang's type A severe spinal kyphoscoliosis
Authors: Wu Hangqin , Ding Jie , Yang Junlin , Sui Wenyuan 
Published: July 2023

BackgroundsThe incidence and characteristics of postoperative dysesthesia (POD) have not been reported for posterior vertebral column resection (PVCR) in the treatment of severe spinal kyphoscoliosis.ObjectiveThe objective of the study is to investigate the incidence and characteristics of POD in PVCR without anterior support applied in Yang's type A severe spinal kyphoscoliosis.Material and methodsFrom August 2010 to December 2019, 167 patients diagnosed with Yang's type A severe spinal kyphoscoliosis who underwent PVCR without anterior support applied were retrospectively reviewed. All the patients were monitored using five modes of intraoperative multimodal neurophysiological monitoring. Neuromonitoring data, radiographic parameters, and neurological complications were reviewed and analyzed. The incidence and characteristics of POD were further summarized. POD was defined as dysesthetic pain or burning dysesthesia which could be caused by spinal cord kinking or dorsal root ganglion (DRG) injury but with no motor deficits.ResultsPVCR without anterior support was successfully conducted in all 167 patients. Intraoperative monitoring events occurred in five patients. One out of these five patients showed postoperative spinal cord injury (Frankel level C) but completely recovered within 9 months postoperation (Frankel level E). The number of levels and osteotomy space for vertebra resection were 1.28 and 3.6 cm, respectively. POD was confirmed in three patients (3/167, 1.8%), characterized as kyphosis with the apex vertebrae in T12 with the kyphotic Cobb angles of 100°, 115°, and 122°, respectively. The osteotomy space of vertebra resection in these three patients were 3.9, 3.8, and 4.2 cm, respectively. After the treatment by drug administration, they reported pain relief for 12–36 days. The pain gradually moved to the distal end of a proper DRG innervated region near the end.ConclusionsIn this study, the incidence rate of POD in Yang's type A severe spinal kyphoscoliosis patients who underwent PVCR without anterior support applied was 1.8% (3/167). Evoked potential monitoring could not detect the occurrence of POD. POD in Yang's type A severe spinal kyphoscoliosis after PVCR could be ascribed to spinal cord kinking and DRG injury.
The impact of general practice team composition and climate on staff and patient experiences: a systematic review
Authors: Abrams Ruth , Jones Bridget , Gage Heather 
Published: July 2023

BackgroundRecent policy initiatives seeking to address the workforce crisis in general practice have promoted greater multidisciplinarity. Evidence is lacking on how changes in staffing and the relational climate in practice teams affect the experiences of staff and patients.AimTo synthesise evidence on how the composition of the practice workforce and team climate affect staff job satisfaction and burnout, and the processes and quality of care for patients.MethodFour different searches were carried out between December 2021 and March 2022 using MEDLINE, Embase, Cochrane, CINAHL PsycINFO and Web of Science. PRISMA guidelines were followed and data were synthesised thematically.ResultsEleven studies set in primary care were included, 10 from US integrated healthcare systems, one from Canada. Findings indicate that when teams are understaffed and work environments are stressful, patient care and staff wellbeing suffer. However, a good relational climate can buffer against burnout and protect patient care. Good team dynamics and team cohesion have a greater impact on job satisfaction and patient care coordination than team composition; stable team membership is also important. Better patient experiences are associated with female physicians. However, these same physicians are at higher risk of burnout.ConclusionEvidence regarding team composition and team climate in relation to staff and patient outcomes remains limited. Challenges exist when drawing conclusions across different team compositions and differing definitions of team climate. Future research may benefit from exploring the conditions that generate a productive team climate.
Exploring patient, informal carer and care professional perspectives to understand the key clinical and non-clinical care needs of those living with multiple long-term conditions (MLTC)
Authors: Simpson Glenn , Okamoto Ikumi , Morrison Leanne , Santer Miriam , Farmer Andrew , Dambha-Miller Hajira 
Published: July 2023

BackgroundMultiple long-term conditions (MLTC) are the co-occurrence of two or more chronic long-term conditions. While numerous studies have examined health and social care needs associated with MLTC, there has been limited research exploring both clinical and non-clinical care needs of this patient cohort from a range of perspectives.AimTo explore patient, informal carer, and care professional perspectives to identify what are the key clinical and non-clinical needs for optimal care in people with MLTC.MethodSemi-structured interviews were conducted with a representative sample of 29 patients, informal carers, and professionals, using video-link or telephone. Inductive reflexive thematic analysis was used to analyse and interpret the data.ResultsA range of clinical and non-clinical care needs were identified, including supporting patient self-management of conditions, informal carer involvement in care decisions, limited knowledge of MLTC among care professionals, and mental health and socioeconomic needs of individuals were emphasised as important to optimal care in MLTC.Improvements to optimise care included: more personalised care interventions, improved care professional understanding of MLTC care needs, involvement of informal carers in care decisions and promoting patient self-management of conditions and increased consideration given to non-clinical care needs.ConclusionMLTC patients often have a complex range of clinical and non-clinical care needs. This requires a holistic and coordinated care approach, enabling care to be tailored to personal care needs of individuals with MLTC.