bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cosmological measurements from void-galaxy and galaxy-galaxy clustering in the Sloan Digital Sky Survey
Authors: Woodfinden Alex , Percival Will J , Nadathur Seshadri , Winther Hans A , Fraser T S , Massara Elena , Paillas Enrique , Radinović Slađana 
Published: June 2023

ABSTRACT
We present the cosmological implications of measurements of void-galaxy and galaxy-galaxy clustering from the Sloan Digital Sky Survey (SDSS) Main Galaxy Sample (MGS), Baryon Oscillation Spectroscopic Survey (BOSS), and extended BOSS (eBOSS) luminous red galaxy catalogues from SDSS Data Release 7, 12, and 16, covering the redshift range 0.07 &lt; $z$ &lt; 1.0. We fit a standard ΛCDM cosmological model as well as various extensions, including a constant dark energy equation of state not equal to −1, a time-varying dark energy equation of state, and these same models allowing for spatial curvature. Results on key parameters of these models are reported for void-galaxy and galaxy-galaxy clustering alone, both of these combined, and all these combined with measurements from the cosmic microwave background (CMB) and supernovae (SN). For the combination of void-galaxy and galaxy-galaxy clustering, we find tight constraints of Ωm = 0.356 ± 0.024 for a base ΛCDM cosmology, $\Omega _\mathrm{m} = 0.391^{+0.028}_{-0.021}, w = -1.50^{+0.43}_{-0.28}$ additionally allowing the dark energy equation of state $w$ to vary, and $\Omega _\mathrm{m} = 0.331^{+0.067}_{-0.094}, w=-1.41^{+0.70}_{-0.31},\ \mathrm{and}\ \Omega _\mathrm{k} = 0.06^{+0.18}_{-0.13}$ further extending to non-flat models. The combined SDSS results from void-galaxy and galaxy-galaxy clustering in combination with CMB+SN provide a 30 per cent improvement in parameter Ωm over CMB+SN for ΛCDM, a 5 per cent improvement in parameter Ωm when $w$ is allowed to vary, and a 32 per cent and 68 per cent improvement in parameters Ωm and Ωk when allowing for spatial curvature.
Radio variable and transient sources on minute time-scales in the ASKAP pilot surveys
Authors: Wang Yuanming , Murphy Tara , Lenc Emil , Mercorelli Louis , Driessen Laura , Pritchard Joshua , Lao Baoqiang , Kaplan David L , An Tao , Bannister Keith W , Heald George , Lu Shuoying , Tuntsov Artem , Walker Mark , Zic Andrew 
Published: June 2023

ABSTRACT
We present results from a radio survey for variable and transient sources on 15-min time-scales, using the Australian SKA Pathfinder (ASKAP) pilot surveys. The pilot surveys consist of 505 h of observations conducted at around 1 GHz observing frequency, with a total sky coverage of 1476 deg2. Each observation was tracked for approximately 8 – 10 h, with a typical rms sensitivity of ∼30 μJy beam−1 and an angular resolution of ∼12 arcsec. The variability search was conducted within each 8 – 10 h observation on a 15-min time-scale. We detected 38 variable and transient sources. Seven of them are known pulsars, including an eclipsing millisecond pulsar, PSR J2039−5617. Another eight sources are stars, only one of which has been previously identified as a radio star. For the remaining 23 objects, 22 are associated with active galactic nuclei or galaxies (including the five intra-hour variables that have been reported previously), and their variations are caused by discrete, local plasma screens. The remaining source has no multiwavelength counterparts and is therefore yet to be identified. This is the first large-scale radio survey for variables and transient sources on minute time-scales at a sub-mJy sensitivity level. We expect to discover ∼1 highly variable source per day using the same technique on the full ASKAP surveys.
Prospects for localizing Planet 9 with a future Uranus mission
Authors: Bucko Jozef , Soyuer Deniz , Zwick Lorenz 
Published: June 2023

ABSTRACT
Past years have seen various publications attempting to explain the apparent clustering features of trans-Neptunian objects, the most popular explanation being an unconfirmed ‘Planet 9’. The recently proposed Uranus Orbiter and Probe mission by NASA’s Planetary Science and Astrobiology Decadal Survey could offer the opportunity to precisely determine Planet 9’s sky location and mass by carefully monitoring ranging data during the interplanetary cruise. We use Monte Carlo Markov chain methods to reconstruct simulated spacecraft trajectories in a simplified Solar system model containing Planet 9, providing an estimate of the mission’s localization capacity depending on sky location, Earth-spacecraft Doppler link noise level and data collection rate. We characterize the noise via the Allan deviation σA, scaled to the Cassini-era value $\sigma _{\rm A}^{\rm \scriptscriptstyle Cass} = 3 \times 10^{-15}$, finding that daily measurements of the spacecraft position can lead to ∼0.2 deg2 localization of Planet 9 (assuming M9 = 6.3 M⊕, d9 = 460 au). As little as a three-fold improvement in σA drastically decreases the sky localization area size to ∼0.01 deg2. Thus, we showcase that a future Uranus mission carries a significant potential also for non-Uranian science.
Transit time thermalization and the stochastic wave energization of ions in quasi-perpendicular shocks
Authors: Stasiewicz Krzysztof 
Published: June 2023

ABSTRACT
It is shown that the ratio of the proton convective gyroradius rEp, to the width of the shock ramp D, controls the thermalization process of ions in quasi-perpendicular shocks. When rEp/D &gt; 1, the solar wind beam energy is rapidly converted to gyration (thermal) energy by a universal, transit time thermalization (TTT) mechanism that does not require any collisions, waves, or instabilities. The TTT of ions on magnetic field gradients is followed by stochastic wave energization (SWE) on electric field gradients. Ions heated by TTT and SWE processes are subject to additional ballistic surfing acceleration caused by the convection field in the shock front. These three fundamental ion energization mechanisms are studied with test-particle simulations in a realistic shock model, and are shown to be consistent with magnetospheric multiscale measurements in the Earth’s bow shock. It is also shown that shock reflected ions are produced by the SWE process and not by the cross-shock potential. An explanation for downstream oscillations in quasi-perpendicular shocks is also provided.
Cooperativity boosts affinity and specificity of proteins with multiple RNA-binding domains
Authors: Stitzinger Simon H , Sohrabi-Jahromi Salma , Söding Johannes 
Published: June 2023

Abstract
Numerous cellular processes rely on the binding of proteins with high affinity to specific sets of RNAs. Yet most RNA-binding domains display low specificity and affinity in comparison to DNA-binding domains. The best binding motif is typically only enriched by less than a factor 10 in high-throughput RNA SELEX or RNA bind-n-seq measurements. Here, we provide insight into how cooperative binding of multiple domains in RNA-binding proteins (RBPs) can boost their effective affinity and specificity orders of magnitude higher than their individual domains. We present a thermodynamic model to calculate the effective binding affinity (avidity) for idealized, sequence-specific RBPs with any number of RBDs given the affinities of their isolated domains. For seven proteins in which affinities for individual domains have been measured, the model predictions are in good agreement with measurements. The model also explains how a two-fold difference in binding site density on RNA can increase protein occupancy 10-fold. It is therefore rationalized that local clusters of binding motifs are the physiological binding targets of multi-domain RBPs.
Regulation of mature mRNA levels by RNA processing efficiency
Authors: Henfrey Callum , Murphy Shona , Tellier Michael 
Published: June 2023

Abstract
Transcription and co-transcriptional processes, including pre-mRNA splicing and mRNA cleavage and polyadenylation, regulate the production of mature mRNAs. The carboxyl terminal domain (CTD) of RNA polymerase (pol) II, which comprises 52 repeats of the Tyr1Ser2Pro3Thr4Ser5Pro6Ser7 peptide, is involved in the coordination of transcription with co-transcriptional processes. The pol II CTD is dynamically modified by protein phosphorylation, which regulates recruitment of transcription and co-transcriptional factors. We have investigated whether mature mRNA levels from intron-containing protein-coding genes are related to pol II CTD phosphorylation, RNA stability, and pre-mRNA splicing and mRNA cleavage and polyadenylation efficiency. We find that genes that produce a low level of mature mRNAs are associated with relatively high phosphorylation of the pol II CTD Thr4 residue, poor RNA processing, increased chromatin association of transcripts, and shorter RNA half-life. While these poorly-processed transcripts are degraded by the nuclear RNA exosome, our results indicate that in addition to RNA half-life, chromatin association due to a low RNA processing efficiency also plays an important role in the regulation of mature mRNA levels.
Upstream open reading frame-encoded MP31 disrupts the mitochondrial quality control process and inhibits tumorigenesis in glioblastoma
Authors: Huang Nunu , Chen Zhipeng , Yang Xuesong , Gao Yixin , Zhong Jian , Li Yan , Xiao Feizhe , Wang Xiuxing , Shi Yu , Zhang Nu 
Published: June 2023

Abstract

Background
Mitochondrial hyperpolarization achieved by the elevation of mitochondrial quality control (MQC) activity is a hallmark of glioblastoma (GBM). Therefore, targeting the MQC process to disrupt mitochondrial homeostasis should be a promising approach for GBM therapy.

Methods
We used 2-photon fluorescence microscopy, Fluorescence-Activated Cell Sorting, and confocal microscopy with specific fluorescent dyes to detect the mitochondrial membrane potential (MMP) and mitochondrial structures. Mitophagic flux was measured with mKeima.

Results
MP31, a phosphatase and tensin homolog (PTEN) uORF-translated and mitochondria-localized micropeptide, disrupted the MQC process and inhibited GBM tumorigenesis. Re-expression of MP31 in patient-derived GBM cells induced MMP loss to trigger mitochondrial fission but blocked mitophagic flux, leading to the accumulation of damaged mitochondria in cells, followed by reactive oxygen species production and DNA damage. Mechanistically, MP31 inhibited lysosome function and blocked lysosome fusion with mitophagosomes by competing with V-ATPase A1 for lactate dehydrogenase B (LDHB) binding to induce lysosomal alkalinization. Furthermore, MP31 enhanced the sensitivity of GBM cells to TMZ by suppressing protective mitophay in vitro and in vivo, but showed no side effects on normal human astrocytes or microglia cells (MG).

Conclusions
MP31 disrupts cancerous mitochondrial homeostasis and sensitizes GBM cells to current chemotherapy, without inducing toxicity in normal human astrocytes and MG. MP31 is a promising candidate for GBM treatment.
M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance
Authors: Bailleul Justine , Ruan Yangjingyi , Abdulrahman Lobna , Scott Andrew J , Yazal Taha , Sung David , Park Keunseok , Hoang Hanna , Nathaniel Juan , Chu Fang-I , Palomera Daisy , Sehgal Anahita , Tsang Jonathan E , Nathanson David A , Xu Shili , Park Junyoung O , ten Hoeve Johanna , Bhat Kruttika , Qi Nathan , Kornblum Harley I , Schaue Dorthe , McBride William H , Lyssiotis Costas A , Wahl Daniel R , Vlashi Erina 
Published: June 2023

Abstract

Background
Resistance to existing therapies is a significant challenge in improving outcomes for glioblastoma (GBM) patients. Metabolic plasticity has emerged as an important contributor to therapy resistance, including radiation therapy (RT). Here, we investigated how GBM cells reprogram their glucose metabolism in response to RT to promote radiation resistance.

Methods
Effects of radiation on glucose metabolism of human GBM specimens were examined in vitro and in vivo with the use of metabolic and enzymatic assays, targeted metabolomics, and FDG-PET. Radiosensitization potential of interfering with M2 isoform of pyruvate kinase (PKM2) activity was tested via gliomasphere formation assays and in vivo human GBM models.

Results
Here, we show that RT induces increased glucose utilization by GBM cells, and this is accompanied with translocation of GLUT3 transporters to the cell membrane. Irradiated GBM cells route glucose carbons through the pentose phosphate pathway (PPP) to harness the antioxidant power of the PPP and support survival after radiation. This response is regulated in part by the PKM2. Activators of PKM2 can antagonize the radiation-induced rewiring of glucose metabolism and radiosensitize GBM cells in vitro and in vivo.

Conclusions
These findings open the possibility that interventions designed to target cancer-specific regulators of metabolic plasticity, such as PKM2, rather than specific metabolic pathways, have the potential to improve the radiotherapeutic outcomes in GBM patients.
Radiotherapy and radiosurgery for meningiomas
Authors: Chen William C , Lucas Calixto-Hope G , Magill Stephen T , Rogers C Leland , Raleigh David R 
Published: June 2023

AbstractMeningiomas comprise a histologically and clinically diverse set of tumors arising from the meningothelial lining of the central nervous system. In the past decade, remarkable progress has been made in deciphering the biology of these common neoplasms. Nevertheless, effective systemic or molecular therapies for meningiomas remain elusive and are active areas of preclinical and clinical investigation. Thus, standard treatment modalities for meningiomas are limited to maximal safe resection, radiotherapy, or radiosurgery. This review examines the history, clinical rationale, and future directions of radiotherapy and radiosurgery as integral and effective treatments for meningiomas.
Meningioma in the elderly
Authors: Amoo Michael , Henry Jack , Farrell Michael , Javadpour Mohsen 
Published: June 2023

Abstract
Meningiomas are the most common primary intracranial neoplasm, accounting for approximately 40% of all primary brain tumors. The incidence of meningioma increases with age to 50 per 100,000 in patients older than 85. As the population ages, an increasing proportion of meningioma patients are elderly. Much of this increase is accounted for by an increase in incidental, asymptomatic diagnoses, which have a low risk of progression in the elderly. The first-line treatment of symptomatic disease is resection. Fractionated radiotherapy (RT) or stereotactic radiosurgery (SRS) can be considered as primary treatment where surgery is not feasible, or as adjuvant therapy in cases of subtotal resection or high grade histopathology. The role of RT/SRS, particularly following gross total resection of atypical meningioma, is unclear and requires further evaluation. There is an increased risk of perioperative and postoperative morbidity in the elderly and therefore management decisions must be tailored to individual circumstances. Good functional outcomes can be achieved in selected patients and age alone is not a contraindication to intervention. The immediate postoperative course is an important determinant of prognosis. Therefore, careful preoperative evaluation and avoidance of complications are necessary to optimize outcomes.
The clinical and genomic features of seizures in meningiomas
Authors: Dincer Alper , Jalal Muhammad I , Gupte Trisha P , Vetsa Shaurey , Vasandani Sagar , Yalcin Kanat , Marianayagam Neelan , Blondin Nicholas , Corbin Zachary , McGuone Declan , Fulbright Robert K , Erson-Omay Zeynep , Günel Murat , Moliterno Jennifer 
Published: June 2023

Abstract
Meningiomas are the most common central nervous system tumors. Although these tumors are extra-axial, a relatively high proportion (10%–50%) of meningioma patients have seizures that can substantially impact the quality of life. Meningiomas are believed to cause seizures by inducing cortical hyperexcitability that results from mass effect and cortical irritation, brain invasion, or peritumoral brain edema. In general, meningiomas that are associated with seizures have aggressive features, with risk factors including atypical histology, brain invasion, and higher tumor grade. Somatic NF2 mutated meningiomas are associated with preoperative seizures, but the effect of the driver mutation is mediated through atypical features. While surgical resection is effective in controlling seizures in most patients with meningioma-related epilepsy, a history of seizures and uncontrolled seizures prior to surgery is the most significant predisposing factor for persistent postoperative seizures. Subtotal resection (STR) and relatively larger residual tumor volume are positive predictors of postoperative seizures. Other factors, including higher WHO grade, peritumoral brain edema, and brain invasion, are inconsistently associated with postoperative seizures, suggesting they might be crucial in the development of an epileptogenic focus, but do not appear to play a substantial role after seizure activity has been established. Herein, we review and summarize the current literature surrounding meningioma-related epilepsy and underscore the interaction of multiple factors that relate to seizures in patients with meningioma.
The clinical, genetic, and immune landscape of meningioma in patients with NF2-schwannomatosis
Authors: Gregory Grace E , Islim Abdurrahman I , Hannan Cathal John , Jones Adam P , Hammerbeck-Ward Charlotte , Rutherford Scott A , Freeman Simon R , Lloyd Simon , Kalamarides Michel , Smith Miriam J , Couper Kevin , McBain Catherine A , Jenkinson Michael D , Brough David , King Andrew T , Evans D Gareth , Pathmanaban Omar N 
Published: June 2023

Abstract
NF2-schwannomatosis is the most common genetic predisposition syndrome associated with meningioma. Meningioma in NF2-schwannomatosis is a major source of morbidity and mortality. This is due to accumulative tumor burden in patients with synchronous schwannomas and ependymomas, sometimes including complex collision tumors. Balancing the impact of multiple interventions against the natural history of various index tumors, and the ongoing risk of de novo tumors over an individual’s lifetime makes decision-making complex. The management of any given individual meningioma is often different from a comparable sporadic tumor. There is typically a greater emphasis on conservative management and tolerating growth until a risk boundary is reached, whereby symptomatic deterioration or higher risk from anticipated future treatment is threatened. Management by high-volume multidisciplinary teams improves quality of life and life expectancy. Surgery remains the mainstay treatment for symptomatic and rapidly enlarging meningioma. Radiotherapy has an important role but carries a higher risk compared to its use in sporadic disease. Whilst bevacizumab is effective in NF2-associated schwannoma and cystic ependymoma, it has no value in the management of meningioma. In this review, we describe the natural history of the disease, underlying genetic, molecular, and immune microenvironment changes, current management paradigms, and potential therapeutic targets.
Nicotine Pouch Awareness and Use Among Youth, National Youth Tobacco Survey, 2021
Authors: Kramer Renee D , Park-Lee Eunice , Marynak Kristy L , Jones Jamal T , Sawdey Michael D , Cullen Karen A 
Published: June 2023

Abstract

Introduction
This manuscript examines prevalence of awareness and use of nicotine pouches among U.S. middle and high school students by sociodemographic characteristics and other tobacco product use and characterizes nicotine pouch and other tobacco product use behaviors among current nicotine pouch users.

Aims and Methods
Data are from the 2021 National Tobacco Youth Survey, a cross-sectional, school-based survey of middle and high school students (N = 20 413; overall response rate: 44.6%), which included questions on nicotine pouches in 2021 for the first time. Prevalence estimates, 95% confidence intervals, and estimated population counts were assessed for nicotine pouch awareness, ever use, and current (past 30 days) use, and for use behaviors related to nicotine pouches (frequency of use, flavor(s) used) and other tobacco products (ever, current, frequency of use) among current nicotine pouch users.

Results
Over one-third of students (35.5%) had ever heard of nicotine pouches. An estimated 1.9% (490 000) reported ever using them, while 0.8% (200 000) reported current use. Among current nicotine pouch users, 61.6% reported flavored nicotine pouch use, 64.2% reported current e-cigarette use, and 52.6% used multiple (≥2) tobacco products. Current use of nicotine pouches was common among current smokeless tobacco users (41.3%).

Conclusions
Overall, in 2021, while relatively few students had ever tried nicotine pouches or currently used them, more than one-third had heard of them. Current nicotine pouch users tended to use other tobacco products, particularly e-cigarettes and smokeless tobacco. Given previous rapid increases in youth uptake of e-cigarettes, it is important to continue monitoring nicotine pouch use among young people.

Implications
This study’s findings provide an important baseline for future monitoring of nicotine pouch awareness and use among middle and high school students. Emerging tobacco products, particularly those that are flavored, widely available, discreet, and inexpensive have the potential to attract youth. Given the potential of these products to appeal to young people, ongoing monitoring of nicotine pouch use behaviors is important to inform public health and regulatory efforts.
Relative Effectiveness of the Cell-Based Quadrivalent Influenza Vaccine in Preventing Cardiorespiratory Hospitalizations in Adults Aged 18–64 Years During the 2019–2020 US Influenza Season
Authors: Imran Mahrukh , Puig-Barbera Juan , Ortiz Justin R , Lopez-Gonzalez Lorena , Dean Alex , Bonafede Machaon , Haag Mendel 
Published: June 2023

Abstract

Background
The mammalian cell-based quadrivalent inactivated influenza vaccine (IIV4c) has advantages over egg-based quadrivalent inactivated influenza vaccine (IIV4e), as production using cell-derived candidate viruses eliminates the opportunity for egg adaptation. This study estimated the relative vaccine effectiveness (rVE) of IIV4c versus IIV4e in preventing cardiorespiratory hospitalizations during the 2019–2020 US influenza season.

Methods
We conducted a retrospective cohort study using electronic medical records linked to claims data of US individuals aged 18–64 years. We assessed rVE against cardiorespiratory hospitalizations and against subcategories of this outcome, including influenza, pneumonia, myocardial infarction and ischemic stroke, and respiratory hospitalizations. We used a doubly robust inverse probability of treatment weighting and logistic regression model to obtain odds ratios (ORs; odds of outcome among IIV4c recipients/odds of outcome among IIV4e recipients) adjusted for age, sex, race, ethnicity, geographic region, vaccination week, health status, frailty, and healthcare resource utilization. rVE was calculated as 100(1 − ORadjusted).

Results
In total, 1 491 097 individuals (25.2%) received IIV4c, and 4 414 758 (74.8%) received IIV4e. IIV4c was associated with lower odds of cardiorespiratory (rVE, 2.5% [95% confidence interval, 0.9%–4.1%]), respiratory (3.7% [1.5%–5.8%]), and influenza (9.3% [0.4%–17.3%]) hospitalizations among adults 18–64 years of age. No difference was observed for the other outcomes.

Conclusions
This real-world study conducted for the 2019–2020 season demonstrated that vaccination with IIV4c was associated with fewer cardiorespiratory, respiratory, and influenza hospitalizations compared with IIV4e.