bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunotherapy In Autism Spectrum Disorder; A Case Series
Authors: Agdere S. F. , Topaloglu P. , Erata M. , Karacetin G. , Yapici Z. 
Published: August 2023

IntroductionResearches has shown that a subset of the autism spectrum disorder (ASD) population presents with immune dysregulation. Based upon the immunological abnormalities, various treatment modalities have been applied to children with ASD. One immunomodulatory treatment that has been studied in ASD is intravenous immunoglobulins (IVIG).ObjectivesThis report is based upon two hypotheses: autism etiology may be closely related to neuroinflammation; and, an effective treatment should restore the individual’s comminication skills. In this report, we present two cases who were diagnosed with ASD and received IVIG treatment.MethodsCase A is a 5-year-old female patient who was diagnosed with ASD at the age of 3. The second case, B is a 9 -year-old male patient who is a 7th grade student and was also diagnosed with ASD at the age of 3. The first patient’s autism symptoms was noticed by her family at the age of 2. Although she had the ability to coordinate eye contact, understood simple commands, she was observed to lose all her acquired developmental skills one by one at around 18-24 months. Towards the age of 3, stereotypical movements such as turning around and flapping wings, started. Similarly, the second patient’s acquired skills were lost around at the age of 2-3, after having recurrent infections. Based on deficits in social‐emotional reciprocity, deficits in nonverbal communicative behaviors used for social interaction and restricted/repetitive patterns of behavior, both patients were diagnosed with ASD. Considering that autoimmune mechanisms may have been affected in ASD, IVIG treatment was initiated at 1 g/kg/month. Case A received IVIG once in a month, total 5 infusions had been applied. Case B received total 12 infusions with the same protocol. Treatment response was assessed with the Childhood Autism Rating Scale (CARS).ResultsIn these two ASD cases which were treated with IVIG ,a subjective partial reduction in autism symptoms and an objective decrease in CARS scores were detected. Current evidence suggests that there are various factors contributing to the development of autism and different combinations of these aspects give rise to different variations of some ASD subtypes. Recent studies in this field indicate a possible connection between the immune system impairments and ASD. This report, therefore, provide support for the notion that at least a subset of children with ASD might have immune abnormalities and may respond to the immune modulating effect of IVIG therapy.ConclusionsAlthough, autoimmune or inflammatory etiologies may not explain the majority of cases of autism, it might at least be useful to understand some. Further studies with larger number of patients should be conducted about the use of IVIG in selected patients with ASD.Disclosure of InterestNone Declared
Releation between marital adjustment and somatic symptoms on parents of children with Spina Bifida
Authors: Ulual P. , Ozer V. , Çetiner R. , Alataş I. , Güçlü O. 
Published: August 2023

IntroductionSpine Clearance; which means; SB is a congenital disease . In the first month of pregnancy, the unborn baby’s spine does not close properly is the result . In the spinal cord due to a developmental disorder often causes serious permanent disability . Multi-system associated with this congenital anomaly affected, families with infants and these infants are faced with major challenges in the future. Often the expectations of all parents is to have a normal, healthy children. The birth of a disabled child in the family, family members, their (lives, feelings , behaviors , social life) is a condition that affects negatively.ObjectivesThe SCL-90 is a self repost clinical rating scale oriented toward the symptomatic behavior of psychiatric outpatients. The primary symptom dimensions measured by the SCL-90 are the nine symptom constructs given below: somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, psychotism. Marital adjustment test: A 15-item scale that measures marital satisfaction. It was initially used to differentiate well-adjusted couples from distressed (unsatisfied) couples. The 15 items are answered on a variety of response scales.MethodsIn this study; The SCL-90 and Marital Adjustment Test have been applied on parents of children with Spina Bifida. A total of 40 person was used which is 25 women and 15 men. Above of 1 score has been examined high level for SCL-90 test. For Marital Adjustment Test, we accept the lowest score is 1 and the highest score is 60. Cut-off score accepted is 43. If the parents have score that is below 43, is determined incompatible, and is above 43 is determined compatible.ResultsThe result has been obtained, showed us, the parents who have above 1 score for SCL-90, have below score 43 on Marital Adjustment Test.ConclusionsThe study show that parents who have somatization problems are not align with their partners. Participants have symptomatic problems because of their children health situation can cause an unaligned marriage. This suggests that parents of patients with diseases like SB should get the needed psychiatric help and supportive care during the course of treatment.Disclosure of InterestNone Declared
Psychiatric Comorbidity and Length of Stay in a general hospital
Authors: Fernández Fernández R. , del Sol Calderón P. , Izquierdo de la Puente Á. , Blanco Fernández R. , Martín García M. 
Published: August 2023

IntroductionPsychiatric comorbidity has a significant impact on the patient’s overall health, with an increased risk of death for those patients with mental-physical comorbidity (Tan et al., 2021). This impacts, among other things, the average hospital stay of a patient with psychiatric comorbidity. For example, an American study shows that psychiatric comorbidity was associated with greater inpatient utilization, including the risk of additional hospitalizations, days of stay, and hospitalization charges (Sayers et al., 2007). Our study aims to confirm these results in patients admitted to a general hospital for any cause and presenting psychiatric comorbidity.ObjectivesTo compare the mean length of stay of patients admitted to a general hospital for any cause according to whether they have psychiatric comorbidity or not.MethodsWe made a descriptive retrospective study through the use of electronic medical records. The drug use history and average day of hospitalization were obtained for all patients admitted to the inpatient service of a general hospital during a 3-year period.ResultsThe mean length of stay was longer in patients with psychiatric comorbidity (mean = 9.87 days, SD = 15.45) than in patients without psychiatric comorbidity (mean = 5.23 days, SD = 7.16), the difference being statistically significant for the analysis of variance with a small effect size (F = 18.2; p < 0.001, η²=0.038). The assumption of the equality of variances of the two groups is not fulfilled (Levene F = 29.0; p < 0.01) so Welch’s nonparametric test was applied, whose results do not modify those obtained.NMeanSDSENo psychiatric comorbidity2965.237.160.416Psychiatric comorbidity2389.8715.451.002ConclusionsOur results are in line with other studies, showing a longer mean length of stay in those patients admitted for any cause and with associated psychiatric comorbidity. This highlights the importance of having an integrated psychiatry service in a general hospital, as Bronson points out, where they find a shorter mean length of stay in units that have integrated, proactive psychiatric care (Bronson et al., 2019).ReferencesBronson, B. D., Alam, A., & Schwartz, J. E. (2019). The Impact of Integrated Psychiatric Care on Hospital Medicine Length of Stay: A Pre-Post Intervention Design With a Simultaneous Usual Care Comparison. Psychosomatics.Sayers, S. L., Hanrahan, N., Kutney, A., Clarke, S. P., Reis, B. F., & Riegel, B. (2007). Psychiatric comorbidity and greater hospitalization risk, longer length of stay, and higher hospitalization costs in older adults with heart failure. Journal of the American Geriatrics Society.Tan, X. W., Lee, E. S., Toh, M., Lum, A., Seah, D., Leong, K. P., Chan, C., Fung, D., & Tor, P. C. (2021). Comparison of mental-physical comorbidity, risk of death and mortality among patients with mental disorders - A retrospective cohort study. Journal of psychiatric research.Disclosure of InterestNone Declared
Age-Related Differences in Reading Negative Texts on COVID-19
Authors: Popov A. , Tukaiev S. , Rizun V. , Havrylets Y. , Ivaskevych D. , Petrenko-Lysak A. , Yachnik Y. 
Published: August 2023

IntroductionThe worldwide COVID-19 pandemic leads to the development of stress disorders, increased anxiety in the society. One of the strongest factors leading to the development of anxiety, stress in society during a pandemic is the Mass Media. The mechanisms of stressogenic effects of Mass Media remain not completely clear.ObjectivesThe aim of this study was to evaluate age-specific characteristics of gaze behaviour related to the perception of anxiety-provoking information.Methods189 volunteers took part in the study (164 participants aged between 17 and 22 years old (students, control group), 25 people aged between 59 and 71 (experimental group)). Participants were asked to fill in Psychological Stress Measure (PSM-25), Patient Health Questionnaire (PHQ-9), and Generalised Anxiety Disorder Assessment (GAD-7) questionnaires in order to determine their levels of stress, depression, and anxiety. The second stage of the research was an eye-tracking study of text perception - we analysed eye-tracking data during the text perception by using web-eye tracking (EyePass).ResultsTo identify the relevance of COVID-19 information, we compared the perception of positive, neutral and negative texts and detected rather a negativity bias than attraction to the positive or neutral stimuli: fixations positive vs negative (p-value < 0.01), positive vs neutral (p-value < 0.01), neutral vs negative (p-value < 0.01). Under the competitive conditions (higher relevance of negative information during Pandemic) the perception of negative text is characterized by attentional priority. Moreover, it should be taken into account that highly anxious participants showed a negativity bias than attraction to the positive stimuli, and this is typical during quarantine.ConclusionsTherefore, participants showed a negativity bias than attraction to the positive stimuli, and this is typical during quarantine. There are significant age-related differences in gaze behavior while reading text with negative text elements. While the origin of these differences between older and younger adults remains unknown, further research may provide more evidence about the origin of this effect.Disclosure of InterestNone Declared
Alcohol spectrum disorders in women : a review of current data
Authors: Thibaut F. 
Published: August 2023

AbstractEpidemiological studies indicate an alarming narrowing in the gender gap of alcohol and tobacco use especially in adolescents, which may reflect changes in sociocultural patterns in women. Moreover, women use more often alcohol to cope with stress and negative feelings. Pharmacokinetics and pharmacodynamics differences, reward process specificities, and female hormones play a major role in gender differences. Women’s consumption of alcohol may be associated with serious birth and developmental consequences in newborns.Thibaut F et al. WFSBP and IAWMH Guidelines for the treatment of alcohol use disorders in pregnant women. The World Journal of Biological Psychiatry 2019 20(1):17-50Disclosure of InterestNone Declared
Telomere length from peripheral blood DNA in major depressive disorder: a case/control comparison and association with antidepressant treatment response
Authors: Kalinovic R. , Homorogan C. , Nitusca D. , Seclaman E. , Marian C. , Adela B. , Enatescu V. R. 
Published: August 2023

IntroductionMajor depressive disorder (MDD)is one of the most common psychiatric disorders and a large number of patients present a poor response to treatment. Shortening of telomeres physiologically occurs after each cell division and their shortening is also associated with cell ageing. Studies are affirming that patients who suffer from mental illnesses have shorter telomeres in comparison with patients without such affections. 4 The effect of antidepressant medication on the biology of the telomeres was studied very little in humans and the current data suggest that the length of telomeres is a promising target regarding the prognosis and the response to psychotropic treatment.ObjectivesTo analyze the telomere length (TL) from peripheral blood DNA of patients with major depressive disorder (MDD) compared to healthy controls. A second objective was to compare the TL of patients in relation to antidepressant treatment.MethodsWe analysed the clinical data from 16 patients admitted to the Psychiatry Clinic of Timisoara with the diagnosis of MDD and 10 healthy controls. The collection of clinical data was carried out in a structured and standardized manner both on paper and electronically, and the Hamilton Depression Rating Scale (HDRS) was applied to assess the severity of depression. Also, blood samples were collected, and plasma and white blood cells (WBC) were separated by centrifugation. Patients’ samples were collected before and after 12 weeks of escitalopram antidepressant treatment, and a structured diagnostic interview and a standardized depression rating scale were done. DNA was extracted from WBC using the QIAamp DNA Mini Kit (Qiagen), and TL was determined by real time PCR using the Absolute Human Telomere Length Quantification qPCR Assay Kit (Sciencell Research Laboratories) according to the manufacturers’ specifications. The TL expressed as megabases/diploid cell (Mb/DC) were compared between cases and controls using a Mann-Whitney test, and between patients before and after treatment using a Wilcoxon matched-pairs signed rank statistical test.ResultsThe mean±SD telomere length for healthy controls was 0.3614±0.082Mb/DC, for treatment naïve patients was 0.4513±0.199Mb/DC, and for patients after treatment was 0.3476±0.070Mb/DC. There was no statistical significant difference in TL between patients and controls (p=0.266), nor between patients before and after treatment (p=0.055).ConclusionsIn this pilot project of limited sample size there was no difference in TL between MDD patients and healthy controls. Moreover, the TL of patients did not significantly change after 12 weeks of escitalopram antidepressant treatment.Disclosure of InterestNone Declared
loneliness, solitude and social desintegration in the elderly and their relationship to health
Authors: Stoppe G. 
Published: August 2023

AbstractLoneliness has become a big issue in the time of the COVID pandemic. The attention to the topic also has to do with the increase in people living alone in Europe, although this also has to do with prosperity. Living alone does not yet mean being lonely. In the scientific discussion and especially in the measures, a differentiation must be made between loneliness, solitude and social disintegration. Poor social integration is easily measurable and has a lot to do with the physical health (mobility, vision and hearing) of the people concerned. However, the extent to which participation in social and cultural opportunities is possible, for example through the expansion of public transport, also plays an important role.Loneliness, on the other hand, is by definition subjective and strongly linked to mental health. It describes the subjective suffering of missing or unsatisfactory social relationships, lack of integration and security. Loneliness is often found in two peaks, among the young and the old. Political and public health campaigns often focus on social integration measures. However, measures to combat loneliness mean first and foremost recognising mental illness in old age, especially depression. But they also mean providing help to people with long-term mental illness in old age.Disclosure of InterestNone Declared
Efficacy of two intensive and spaced protocols of theta burst transcranial magnetic stimulation in treatment-resistant depression: a double-blind randomized trial
Authors: Cañada Y. , Navalón P. , Benavent P. , Sabater A. , Ribes J. , Livianos L. , Sierra P. 
Published: August 2023

IntroductionDepression is the disease with the greatest burden of disability. Despite pharmacological options, up to 30% of depressions are considered resistant to treatment (RTD). Theta burst transcranial magnetic stimulation (TBS) on the dorsolateral prefrontal cortex allows the application of shorter protocols and with longer-lasting effects than conventional TMS. Its implementation in the Public Health System requires the design of efficient, cost-effective and accessible protocols for patients.ObjectivesThe objective of this project is to assess the efficacy and safety of two intensive and spaced protocols (unilateral and bilateral) of 1800 pulses TBS compared to sham stimulation in outpatients with unipolar and bipolar TRD in a public hospital.MethodsThis project is the 1st double-blind placebo-controlled RCT with TBS in Spain. It is now in the recruitment phase. Patients receive a total of 22 sessions of 1800 pulses in 6 weeks: 5 days/week the 1st and 2nd weeks (10 sessions) and 3 sessions/week the following weeks (12 sessions). Patients are randomized into three groups: i) bilateral, ii) left unilateral, and iii) sham. The main variable is the change in the HDRS-17 score at the end of treatment compared to baseline. The results were analyzed with a general linear model of HDRS, using time as the intrasubject factor and randomization group as the intersubject factor, using resistance to treatment (Maudsley Score) and diagnosis (bipolar, unipolar) as covariates.ResultsPreliminary results from 13 participants (nbil=4, nuni=4, nsham=5) reveal a significant effect of (group x time) on HDRS change (p= 0.020) with no influence of Maudsley Score or diagnosis. The bilateral group presented a greater decrease in the HDRS with a mean difference of 4,38 points [CI95% 0,17-8,58), (p=0.043)] with respect to the unilateral group and a difference of 8.23 [CI95% 4,24-12,21)(p =0.001)] compared to the sham group.Table 1:Sample description. Data shown are means and standar deviations. In bold significant diferences p<0,05.Bilateral TBS(n=4)UnilateralTBS(n=4)ShamTBS(n=5)Age [M (SD)]55,50(5,80)48,50(16,86)56,40(5,86)Male: Female [n]0:42:23:2Depression:Bipolar disorder [n]3:13:14:1Length of depresive episode (months) [M (SD)]12,00(4,08)16,50(6,61)15,00(5,83)Current number of antidepressants [M (SD)]2,00(0,82)1,75(0,50)2,60(0,55)Maudsley score [M (SD)]7,00(1,82)8,75(1,5)7,90(1,30)Basal HDRS basal [M (SD)]16,00(1,82)19,75(4,03)20,40(3,21)Final HDRS [M (SD)]5,75(3,30)10,75(3,10)17,80(2,49)Response /Remission[n (%)]3:3 (75%)2:0(50:0%)0:0 (0%)Image:ConclusionsThe results demonstrate the preliminary efficacy of intensive TBS protocols relative to sham.Disclosure of InterestNone Declared
Unsupervised neurobiology-driven stratification of clinical heterogeneity in depression
Authors: Colombo F. , Calesella F. , Bravi B. , Fortaner-Uyà L. , Monopoli C. , Maggioni E. , Tassi E. , Zanardi R. , Attanasio F. , Bollettini I. , Poletti S. , Benedetti F. , Vai B. 
Published: August 2023

IntroductionOne of the main obstacles in providing effective treatments for major depressive disorder (MDD) is clinical heterogeneity, whose neurobiological correlates are not clearly defined. A biologically meaningful stratification of depressed patients is needed to promote tailored diagnostic procedures.ObjectivesUsing structural data, we performed an unsupervised clustering to define clinically meaningful clusters of depressed patients.MethodsT1-weighted and diffusion tensor images were obtained from 102 MDD patients. In 64 patients, clinical symptoms, number of stressful life events, severity and exposure to adverse childhood experiences were evaluated using the Beck Depression Inventory (BDI), Schedule of Recent Experiences (SRE), Risky Family Questionnaire (RFQ), and Childhood Trauma Questionnaire (CTQ). Clustering analyses were performed with extracted tract-based fractional anisotropy (TBSS, FSL), cortical thickness, surface area, and regional measures of grey matter volumes (CAT12). Gaussian mixture model was implemented for clustering, considering Support Vector Machine (SVM) as classifier. A 10x2 repeated cross-validation with grid search was performed for hyperparameters tuning and clusters’ stability. The optimal number of clusters was determined by normalized stability, Akaike and Bayesian information criterion. Analyses were adjusted for total intracranial volume, age, and sex. The clinical relevance of the identified clusters was assessed through MANOVA, considering domains of clinical scales as dependent variables and clusters’ labels as fixed factors. Discriminant analysis was subsequently performed to assess the discriminative power of these variables.ResultsCross-validated clustering approach identified 2 highly stable clusters (normalized stability=0.316, AIC=-80292.48, BIC=351329.16). MANOVA showed a significant between-clusters difference in clinical scales scores (p=0.038). Discriminant analysis distinguished the two clusters with an accuracy of 78.1%, with BDI behavioural and CTQ minimisation/denial domains showing the highest discriminant values (0.325 and 0.313).ConclusionsOur results defined two biologically informed clusters of MDD patients associated with childhood trauma and specific clinical profiles, which may assist in targeting effective interventions and treatments.Disclosure of InterestNone Declared
The role of stigma as an obstacle for social inclusion for people with severe mental disorders
Authors: Sartorius N. 
Published: August 2023

AbstractStigma continues to be the main obstacle to the improvement of mental health care and to a life of good quality for people with mental disorders or with the experience of a mental disorder. It affects all that is related to mental illness, not only the person who has the disorder but also the institutions in which people with mental disorders receive treatment, treatment means, such as medications, staff working in mental health care and the family of the person with mental disorder.Recent years have witnessed effective programs against stigma in various countries and it would be logical to expect that work against stigma will be a crucial part of mental health programs. This unfortunately is not the case.The presentation will focus on interventions that have been successful in reducing stigmatisation or its consequences and propose action to reduce stigma.Disclosure of InterestNone Declared