bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplemented Distributed Energy Efficient Clustering Algorithm for Wireless Sensor Networks
Authors: Kochhar Supriya , Madhu Charu , Garg Nidhi 
Published: July 2023

Abstract
Wireless Sensor Networks (WSNs) encompass multiple sensor nodes. There is a restrained amount of energy, memory capacity and information processing ability affiliated to the sensor nodes. So this necessitates the requirement of schemes where energy of individual nodes can be preserved by minimizing the distance over which each node has to send data. This was made possible through clustering protocols. In clustering, the member nodes transfer their recorded data to the cluster leader and the cluster leader communicates the recuperated and ameliorated information to the terminal station thereby conserving energy. Also, lifespan, packet transmission ability, throughput and energy-efficiency of the network are other significant parameters for Wireless Sensor Networks. Clustering methods play a great role in establishing a sound and genuine communication keeping in view the above parameters. Numerous efforts are continuously being made to further ameliorate the pre-existing clustering protocols and enhance the network productivity. In this paper, we have recommended a new clustering algorithm SDEEC (Supplemented Distributed Energy Efficient Clustering) to augment the performance of WSNs. It has been observed by simulative analysis that the novel proposed algorithm SDEEC elevates the lifetime, improves the packet transmission ability, enhances the throughput and even boosts the energy-efficiency of wireless sensor networks thus surpassing the pre-existing DEEC protocol with respect to these parameters.
A cerebral organoid autonomically maintains the shape of the organic muscle cell actuators
Authors: Furusawa Kazuya , Teramae Ryo , Ohashi Hirono , Shimizu Masahiro 
Published: July 2023

Abstract
Neurons are potential building blocks for implementing self-modifying and autonomous functions in robots. Cerebral organoids (COs) can partially reproduce the tissue morphology and cellular diversity of the brain and are suitable for implementing more complex self-modifying and autonomous functions. In this study, we assembled a bio-robot by connecting the CO to a functional muscle cell actuator (MCA). Immunofluorescence staining showed that the CO and MCA were extensively connected via axons. However, no significant changes were observed in the autonomic contraction of the MCA. Conversely, inhibition of the connection between the CO and MCA, which was blocked by a curare, resulted in a significant relaxation of the MCA. This result suggests that the CO controls the balance of the contraction force of the individual myotubes in the MCA, thus maintaining the shape of the MCA. The conclusion from this research could be a basis for an effective strategy for constructing a bio-robot with self-modifying and spontaneous functions using CO.
Loneliness is associated with retrospective self-reports of adverse childhood experiences – A replication study in Ethiopia
Authors: Gerbig Paula , Reinhard Matthias Alexander , Ababu Henok , Rek Stephanie , Amann Benedikt , Adorjan Kristina , Abera Mubarek , Padberg Frank , Jobst Andrea 
Published: July 2023

Abstract

Loneliness and adverse childhood experiences constitute major risk factors for mental disorders, and current research highlights the role of loneliness in the interaction between early life adversities and current psychopathology. However, most studies have been conducted in high-income and highly individualistic countries. Therefore, this study investigates the interplay between adverse childhood experiences, loneliness, social network size, and mental health problems in the low-income and collectivistic country of Ethiopia. The study sample consists of 125 psychiatric outpatients at Jimma University Medical Center, South-West of Ethiopia, suffering from major depressive disorder, bipolar disorder, or psychotic disorders, and 131 non-clinical study participants. Led by an interviewer, participants completed the UCLA Loneliness Scale, the Childhood Trauma Questionnaire, the Social Network Index, and the WHO-5 Well-Being Index. We used Mann-Whitney U Tests, partial correlation, and mediation analysis for data analysis. We found mild to moderate correlations between loneliness and adverse childhood experiences, and loneliness fully mediated the association between adverse childhood experiences and depressive symptoms in both groups. In contrast, social network size was neither correlated with adverse childhood experiences nor did it mediate the association between adverse childhood experiences and depressive symptoms in either group. This study replicates previous findings that loneliness, rather than social network size, is associated with adverse childhood experiences and mediates the pathway to depressive symptoms. This replication supports the transcultural and transdiagnostic generalizability of these findings, even in more collectivistic and low-income settings.
Modelling Large Scale Artery Haemodynamics from the Heart to the Eye in Response to Microgravity
Authors: Caddy Harrison , Kelsey Lachlan , Parker Louis , Green Daniel , Doyle Barry 
Published: July 2023

Abstract
We investigated variations in haemodynamics in response to microgravity across a semi-subject specific three dimensional (3D) continuous arterial network connecting the heart to the eye using computational fluid dynamics (CFD) simulations. Using this model we simulated pulsatile blood flow in an upright Earth-gravity case and a microgravity case. Under microgravity, regional time-averaged wall shear stress (TAWSS) increased and oscillatory shear index (OSI) decreased in upper body arteries, whilst the opposite was observed in the lower body. Between cases, uniform changes in TAWSS and OSI were found in the retina across diameters. This work demonstrates 3D CFD simulations can be performed across continuously connected networks of small and large arteries. Simulated results exhibited similarities to low dimensional spaceflight simulations and measured data – specifically that blood flow and shear stress decrease towards the lower limbs and increase towards the cerebrovasculature and eyes in response to microgravity, relative to an upright position in Earth-gravity.
Effect of Poling and Porosity on BaTiO3 for Piezocatalytic Dye Degradation
Authors: Gaur Akshay , Porwal Chirag , Sharma Moolchand , Chauhan Vishal Singh , Vaish Rahul , Kebaili Imen , Boukhris Imed 
Published: July 2023

Abstract
The presence of both organic and inorganic pollutants in water can represent a threat to our ecosystems and pose a challenge to long-term sustainability. As a result, there is a need to investigate novel methods for addressing environmental remediation. Among a variety of techniques available, piezoelectric catalysis has attracted attention due to its abililty to harness the piezoelectric effect for efficient degradation of pollutants. Herein, porous ceramic barium titnate (BaTiO3) pellets for piezocatalytic dye degradation were synthesized using polymethyl methacrylate (PMMA) as a pore former in 0-30 wt.% proportion through solid state reaction method. The synthesized porous BaTiO3 pellets were characterized in detail by X-ray diffraction, Raman spectroscopy, X-ray photoelectron spectroscopy and field emission scanning electron microscopy. An increase in the degradation of a Methylene Blue (MB) dye with an increase in porosity within the BaTiO3 materials, where a maximum degradation was observed for 30 wt.% PMMA pellet which has a degradation rate that was ~1.75 greater than the dense (0 wt.% PMMA) BaTiO3 ceramic pellet. Furthermore, the synthesized porous BaTiO3 ceramic pellets were pulse poled, where the piezoelectric coefficient (d33) decreased with an increase in porosity. The poled 30 wt.% PMMA porous BaTiO3 pellet showed approximately ~57% MB dye degradation in 180 minutes, which was comparable with 30 wt.% PMMA unpoled BaTiO3 and dense 0 wt.% PMMA poled BaTiO3 ceramic pellet. The study provides insights on the influence of poling of a low density porous ceramic pellets, which are utilised as the piezocatalyst for water remediation.
Necroptosis-related genes are associated with prognostic features of kidney renal clear cell carcinoma
Authors: Wang Yiduo , Pan Ke-Hao , Chen Ming 
Published: July 2023

Abstract
Introduction:
Renal clear cell carcinoma is a kind of typical adult urological system cancer, with 30% of patients developing metastasis and 60% dying 1–2 years after diagnosis. Currently, the progress of tumor immunology and necroptosis has brought new ideas for the kidney cancer therapy. Hence, it is very necessary to find potential targets for immunotherapy combined with necroptosis.
Materials and methods
Based on GSE168845 and necroptosis-related genes, necroptosis-related differentially genes were identified. The prognostic value of DEGs was detected through differential expression analysis, prognostic analysis, as well as Cox regression analysis. The GSE53757 dataset was applied to verify MYCN and CDKN2A expression level. In our cohorts, the association among DEGs and clinicopathological features and overall survival was analyzed. Subsequently, the lasso Cox regression model was constructed to assess the correlation of DEGs with immune score, ICP and OCLR score. To detect the expression of two genes (MYCN, CDKN2A and ZBP1) in KIRC, the qRT-PCR were conducted in different samples. We verified the expression levels of two genes in a normal kidney cell line (HK-2 cells) and two KIRC cell lines (786-O, ACHN). Then, the protein level of MYCN and CDKN2A were detected by IHC. SiRNA was used to silence MYCN and CDKN2A expression in the ACHN cell line. Cell migration was measured by wound healing assays.
Results
The MYCN, CDKN2A and ZBP1 were necroptosis related genes with independent prognostic value, by which a risk prognostic model was determined. In the GSE53757 dataset, the expression of the CDKN2A gene was significantly higher in KIRC tissues compared to the normal tissues, and the expressions of the MYCN gene was significantly lower in KIRC tissues. The MYCN and CDKN2A expression was related to T, M stage and OS in our cohort. The MYCN, CDKN2A and ZBP1 were obviously correlated with immune score, ICP and OCLR score. The expression levels of CDKN2A and ZBP1 were obviously enhanced in KIRC cells than the normal kidney cells, while the expression of MYCN was decreased in KIRC cells. MYCN and CDKN2A were detected with the same results in two kinds of tissues, while ZBP1 was not obviously different. Then, the protein expression of MYCN and CDKN2A were detected by IHC,and found that MYCN and CDKN2A were obviously enhanced in KIRC tissues. The results of wound healing assay showed that, the cell migration ability of the si-CDKN2A group was significantly inhibited and the cell migration property of si-MYCN group was obviously enhanced.
Conclusions
MYCN and CDKN2A are potential targets and valuable prognostic biomarkers for immunotherapy combined with necroptosis in kidney renal clear cell carcinoma. CDKN2A promotes the migration of renal cancer cells. MYCN INHIBITs the migration of renal cancer cells.
Adaptive dual closed-loop trajectory tracking control for a wheeled mobile robot on uneven ground
Authors: Li Li , Qiang Jiaping , Xia Yuanqing , Cao Weiqun 
Published: July 2023

Abstract

In this paper, trajectory tracking problem is investigated for a wheeled mobile robot (WMR) on uneven ground. Firstly, a more accurate dynamic model is developed by introducing a direct current motor model. Secondly, an improved fixed-time extended state observer (FXESO) is proposed to estimate the system states and the lumped disturbance containing unmodeled dynamics of the system and uneven ground. Thirdly, a dual closed-loop control (DCLC) strategy is proposed. For the outer loop control, adaptive kinematic controller (AKC) is presented, which reduces the difficulty of parameter tuning and improves the steady-state accuracy of position errors compared to the classical kinematic controller. For the inner loop control, a dynamic controller based on adaptive non-singular terminal sliding mode control (ANTSMC) and improved FXESO is designed, in which the velocity errors converge to zero in finite time. Finally, numerical simulations and experiment results are carried out to illustrate the effectiveness of the proposed control strategy.
Compliance with MDT recommendations is the key element for patients to benefit from MDT in complicated genitourinary tumors: a single-center data set
Authors: Huang Rui-da , Ma Liang , Ng Derry Minyao , Jia Xiao-long , Lou Peng-Rong , Ren Da-Wei , Wang Su-Ying , Jiang Jun-Hui , Ma Qi 
Published: July 2023

Abstract
Purpose: This study aims to evaluate the applications and benefits of the multiple-disciplinary team (MDT) model in the clinical practices of complicated genitourinary tumors and to explore the importance of patients’ compliance with MDT recommendations.
Methods: This was a descriptive study of 259 MDT consultations in our center over the past five years (2018-2022). All data recorded in the database were retrospectively analyzed, including clinical history, initial decisions, MDT decisions, actual treatments, and efficacy assessments.
Results: A total of 259 consultations were performed on 222 patients with an average age of 65.21±12.87 years old (range,18 to 92 years old). Of the 259 consultations, 149 (57.5%) were for prostate cancer, 48 (18.5%) for kidney cancer, 24 (9.3%) for bladder cancer, 13 (5.0%) forupper tract urothelial cancer, 6 (2.3%) for testicular cancer, 2 (0.8%) for adrenal gland cancer, 6 (2.3%) for multiple primary tumors and 11 (4.2%) for other problems. Patients fully accepted the MDT recommendations in 201 consultations (77.6%); Partially accepted the MDT recommendations in 32 consultations (12.4%). The total rate of compliance was about 90.0% and 226 patients benefitted in the compliance group. Only 2 patients benefitted after MDT consultations in the noncompliance group. Compliance with MDT recommendations was found to be more beneficial for patients than the non-compliance group in our study (P＜0.001).
Conclusion: Our findings suggest that MDT should be recommended for patients with complicated genitourinary cancers. Compliance with recommendations is the key element for patients benefitted from MDT consultations and we should focus on ways to enhance patients’ adherence.
Social Behavior Atlas: A few-shot learning framework for multi-animal 3D social pose estimation, identification, and behavior embedding
Authors: Wei Pengfei , Han Yaning , Chen Ke , Wang Yunke , Liu Wenhao , Wang Zhouwei , Wang Xiaojing , Han Chuanliang , Liao Jiahui , Huang Kang , Cai Shengyuan , Huang Yiting , Wang Nan , Li Jinxiu , Song Yangwangzi , Li Jing , Wang Guo-Dong , Wang Liping , Zhang Ya-Ping 
Published: July 2023

Abstract
The fact that multi-animal behavior quantification is still technically challenging nowadays greatly limits the accuracy and granularity of social behavior analysis. Data labeling of deep-learning-based approaches can be incredibly laborious, especially when multiple animals closely interact with each other, under which circumstances animal identity switching and body occlusions are likely to happen. To overcome the challenge, we designed a novel framework - Social Behavior Atlas (SBeA) and it shows promising results. SBeA utilizes a much smaller number of labeled frames for multi-animal 3D pose estimation, achieves label-free identification recognition, and successfully applies unsupervised dynamic learning for social behavior classification. Our results also demonstrate that SBeA is capable of achieving high performance across various species using existing customized datasets. Therefore, we can build a multi-animal behavior atlas. To start with, we construct a social behavior atlas for autism spectrum disorder (ASD) knockout mice, and SBeA reveals several behavioral biomarkers which were neglected before. These findings highlight the immense potential of SBeA for quantifying subtle social behaviors and provide a new paradigm in the fields of neuroscience and ecology.
Effect of intranasal remifentanil Vs lidocaine on facilitation of laryngeal mask airway insertion and cardiovascular response. A double-blind clinical trial study
Authors: Shetabi Hamidreza , Mahjobipoor Hossein , Bahmani Mona 
Published: July 2023

Abstract
Background laryngeal mask airway (LMA) insertion requires a sufficient depth of anesthesia, relaxation of the jaw muscles, and suppression of airway reflexes to tolerate it inside the hypopharynx. This study aimed to determine and compare the effect of intranasal administration of lidocaine and remifentanil on the condition of LMA insertion and cardiovascular response.Methods This double-blind randomized clinical trial study was conducted on 60 eligible patients undergoing elective surgery under general anesthesia with LMA insertion from March 2019 to March 2020 in Faiz Hospital, Isfahan. After induction of anesthesia and before placing the laryngeal mask, remifentanil 1 µg/kg intranasally in the first group, lidocaine 2% 1 mg/kg in the second group, and normal saline with the same volume in the third group was administered. The primary and secondary outcomes of the study were patients’ demographic information (age, height, weight, BMI, ASA classification), LMA insertion condition (function of the LMA, number of attempts to insert of LMA, complication during LMA insertion), and Hemodynamic changes.Results The first successful attempt to insert the mask was 17 cases (85%) in the remifentanil group, 18 cases (90%) in the lidocaine group, and 15 cases (75%) in the control group (p = 0.61). The performance of the inserted mask was excellent in 70% of the remifentanil group, 80% of the lidocaine group, and 65% of the control group (P = 0.73). Mean systolic and diastolic blood pressure, heart rate, and Spo2 were not significantly different between the three groups at any time. Hemodynamic disturbances were not observed in the three groups of remifentanil (25%,), lidocaine (30%), and normal saline (20%), respectively, and there was no significant difference between the three groups (P = 0.91). Other variables, including the need for extra propofol (p = 0.53), gagging (p = 0.53), cough (p = 0.15), and laryngospasm (p = 0.99) had no significant differences in the three groups.Discussion In the prescription of intranasal remifentanil and lidocaine, the success of laryngeal mask insertion in the first attempt, the proper functioning of the LMA, and the cardiovascular response to laryngeal mask insertion were similar among the groups.Trial registration The trial was registered at the Iranian Clinical Trials Registry registration number: IRCT20180416039326N10, date of registration:19/02/2020, available at (https://en.irct.ir/trial/43238).
Primary care delivery of behavioral weight loss services for adults with cardiovascular risk factors: development of pragmatic practice components and results of a randomized feasibility trial
Authors: Ackermann Ronald T. , Cameron Kenzie A. , Liss David T. , Dolan Nancy , Aikman Cassandra , Carson Amy , Harris Sterling A. , Doyle Kathryn , Cooper Andrew J. , Hitsman Brian 
Published: July 2023

Abstract
Background
Intensive lifestyle interventions (ILI) improve weight loss and cardiovascular risk factors, but health systems face challenges implementing them. We engaged stakeholders to cocreate and evaluate feasibility of primary care implementation strategies and of a pragmatic randomization procedure to be used for a future effectiveness trial.
Methods
The study setting was a single, urban primary care office. Patients with BMI ≥ 27 and ≥ 1 cardiovascular risk factor were sent a single electronic health record (EHR) message between December 2019 and January 2020 offering services to support an initial weight loss goal of about 10 pounds in 10 weeks. All patients who affirmed weight loss interest were pragmatically enrolled in the trial and offered “Basic Lifestyle Services” (BLS), including a scale that transmits weight data to the EHR using cellular networks, a coupon to enroll in lifestyle coaching resources through a partnering fitness organization, and periodic EHR messages encouraging use of these resources. About half (n = 42) of participants were randomized by an automated EHR algorithm to also receive “Customized Lifestyle Services” (CLS), including weekly email messages adapted to individual weight loss progress and telephonic coaching by a nurse for those facing challenges. Interventions and assessments spanned January to July 2020, with interference by the coronavirus pandemic. Weight measures were collected from administrative sources. Qualitative analysis of stakeholder recommendations and patient interviews assessed acceptability, appropriateness, and sustainability of intervention components.
Results
Over 6 weeks, 426 patients were sent the EHR invitation message and 80 (18.8%) affirmed interest in the weight loss goal and were included for analysis. EHR data were available to ascertain a 6-month weight value for 77 (96%) patients. Overall, 62% of participants lost weight; 15.0% exhibited weight loss ≥ 5%, with no statistically significant difference between CLS or BLS arms (p = 0.85). CLS assignment increased participation in daily self-weighing (43% versus 21% of patients through 12 weeks) and enrollment in referral-based lifestyle support resources (52% versus 37%).
Conclusions
This preliminary study demonstrates feasibility of implementation strategies for primary care offices to offer and coordinate ILI core components, as well as a pragmatic randomization procedure for use in a future randomized comparative trial.
ClinicalTrials.gov Identifier: NCT03998046 (protocol posted 25/06/2019)
Health service use associated with loneliness and social isolation among older adults in Australia
Authors: Majmudar Ishani Kartik , Mihalopoulos Cathrine , Abimanyi-Ochom Julie , Mohebbi Mohammadreza , Lim Michelle H. , Engel Lidia 
Published: July 2023

Abstract

Background
Loneliness and social isolation among older adults are associated with a significant health burden. However, less is known about the impact of loneliness and social isolation on health service use (HSU). The aim of this study is to examine whether loneliness and social isolation are associated with increased HSU among older adults in Australia.
Methods
Data were derived from three waves (2009, 2013, and 2017) of the nationally representative longitudinal Household Income and Labour Dynamics of Australia (HILDA) survey from individuals aged 65 years and older. Outcomes included health professional visits and hospital admissions in the past year. Generalized estimating equations were used to investigate longitudinal associations between the experience of loneliness and/or social isolation with HSU.
Results
Compared to older adults who neither experienced loneliness nor social isolation, loneliness was significantly associated with more General Practitioner (GP) visits (incident rate ratio [IRR] = 1.13, 95%-CI [1.05, 1.23] and more hospital admissions (IRR = 1.29, 95%-CI [1.11,1.50)). Social isolation was associated with more GP visits (IRR = 1.14, 95%-CI [1.05,1.29]). Experiencing both loneliness and social isolation was associated with more GP visits (IRR = 1.44, 95%-CI [1.04–1.97]) and more hospitalisations (IRR = 1.75, 95%-CI [1.2, 2.56]).
Conclusions
Loneliness and social isolation among older adults were significantly associated with increased health service use, including more visits to GPs and higher hospital admission rates. The findings highlight the need to address these factors for improved health outcomes and potential reduction in healthcare costs.