bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low fluoroscopy permanent His bundle pacing using a new electroanatomic mapping system (KODEX EPD). A multicenter experience
Authors: Scarà Antonio , Golia Paolo , Grieco Domenico , Borrelli Alessio , De Ruvo Ermenegildo , Bressi Edoardo , Politano Alessandro , De Luca Lucia , Bruni Giuseppe , Fagagnini Alessandro , Panuccio Marco , Rebecchi Marco , Zecchi Paolo , Solimene Francesco , Calò Leonardo , Sciarra Luigi 
Published: December 2022

AbstractBackgroundHis bundle pacing (HBP) may be a challenging procedure, often involving a long fluoroscopic time (FT) and a long procedural time (PT). We sought to evaluate whether the use of a new nonfluroscopic mapping (NFM) system, the KODEX‐EPD, is able to reduce FT and PT when mapping is performed by the pacing catheter rather than an electrophysiological mapping catheter.Methods and ResultsWe included 46 consecutive patients (77 ± 8 years; 63% male) who underwent HBP; in 22 a NFM‐guided procedure with the KODEX‐EPD system was performed (group 1), whereas in 24 a conventional fluoroscopy‐guided approach was used (group 2). Pacing indications were sick sinus syndrome in 13, atrioventricular block in 21, and cardiac resynchronization therapy in 12 cases. Both a lumen‐less fixed helix lead and a stylet‐driven extendable helix lead were used, respectively, in 24% and 76% of patients. HBP was successful in 22 patients (100%) in group 1 and 23 patients (96%) in group 2. The FT was significantly reduced in group 1 (183 ± 117 s vs 464.1 ± 352 s in group 2, p = .012). There were no significant differences between groups in PT and other procedural outcomes.ConclusionsThe KODEX‐EPD system may be safely used in HBP procedures. It is effective in reducing ionizing radiation exposure, as evidenced by the significant drop in FT, without increasing PT.
Bringing contribution–receipt (im)balance to team–member exchange research: A moderated mediation model
Authors: Liu Xin , Zhang Yucheng , Chen Wansi , Li Wen‐Dong , Ni Dan 
Published: December 2022

SummaryWhile emerging studies pay much attention to the team–member exchange (TMX) relationship, they have produced mixed findings on TMX consequences. To clarify such inconsistencies, our research highlights the importance of distinguishing TMX contribution from TMX receipt and investigates the influence of TMX contribution–receipt (im)balance. Specifically, drawing upon conservation of resources (COR) theory and the TMX literature, we examine the impacts of TMX contribution–receipt (im)balance on emotional exhaustion and subsequently on silence. We also investigate the moderating role of authoritarian leadership in the aforementioned mediation model. Our pilot study demonstrated sufficient distinction between TMX contribution and TMX receipt scales. Two independent field studies consistently showed that compared with imbalanced situations, TMX contribution–receipt balance was associated with lower emotional exhaustion. In balanced situations, emotional exhaustion was lower when the balance was at a high rather than a low level (Study 1). Regarding imbalanced scenarios, a high contribution–low receipt condition was related to greater emotional exhaustion than a low contribution–high receipt condition (Study 2). Both studies also showed that the indirect effect of TMX contribution–receipt (im)balance on silence through emotional exhaustion was more pronounced when authoritarian leadership was high rather than low.
Soy lecithin increases the stability and lipolysis of encapsulated algal oil and probiotics complex coacervates
Authors: Zhang Weiqian , Chen Ying , Wang Weifei , Lan Dongming , Wang Yonghua 
Published: December 2022

AbstractBACKGROUNDCo‐encapsulation of probiotics and omega‐3 oil using complex coacervation is an effective method for enhancing the tolerance of probiotics under adverse conditions, whereas complex coacervation of omega‐3 oil was found to have low lipid digestibility. In the present study, gelatin (GE, 30 g kg−1) and gum arabic (GA, 30 g kg−1) were used to encapsulate Lactobacillus plantarum WCFS1 and algal oil by complex coacervation to produce microcapsules containing probiotics (GE‐P‐GA) and co‐microcapsules containing probiotics and algal oil (GE‐P‐O‐GA), and soy lecithin (SL) was added to probiotics‐algal oil complex coacervates [GE‐P‐O(SL)‐GA] to enhance its stability and lipolysis. Then, we evaluated the viability of different microencapsulated probiotics exposed to freeze‐drying and long‐term storage, as well as the survival rate and release performance of encapsulated probiotics and algal oil during in vitro digestion.RESULTSGE‐P‐O(SL)‐GA had a smaller particle size (51.20 μm), as well as higher freeze‐drying survival (90.06%) of probiotics and encapsulation efficiency of algal oil (75.74%). Moreover, GE‐P‐O(SL)‐GA showed a higher algal oil release rate (79.54%), lipolysis degree (74.63%) and docosahexaenoic acid lipolysis efficiency (64.8%) in the in vitro digestion model. The viability of microencapsulated probiotics after simulated digestion and long‐term storage at −18,4 and 25 °C was in the order: GE‐P‐O(SL)‐GA > GE‐P‐O‐GA > GE‐P‐GA.CONCLUSIONAs a result of its amphiphilic properties, SL strongly affected the physicochemical properties of probiotics and algal oil complex coacervates, resulting in higher stability and more effective lipolysis. Thus, the GE‐P‐O(SL)‐GA can more effectively deliver probiotics and docosahexaenoic acid to the intestine, which provides a reference for the preparation of high‐viability and high‐lipolysis probiotics‐algal oil microcapsules. © 2022 Society of Chemical Industry.
Uterine Anteroposterior Diameter Measured by Transvaginal Sonography is a Predictor for Dysmenorrhea in Patients With and Without Endometriosis
Authors: Che Jiahui , Gao Yang , Sun Meiling , Zhou Shuang , Lu Pengrong , Zhao Ting 
Published: December 2022

PurposeThe aim of this study was to determine the correlation between uterine diameters and menstrual abdominal pain intensity in patients with and without endometriosis (EM), and the independent influence of EM on the pain intensity.MethodsUterine diameters and the diagnosis of adenomyosis were ascertained by transvaginal ultrasonography (TVS). Menstrual abdominal pain intensity was estimated by visual analog scale (VAS). Linear regression was used to figure out the impact of uterine diameters and EM on the VAS scores. Logistic regression was used to calculate the correlation between uterine diameters and the diagnosis of adenomyosis. The cutoff values of uterine anteroposterior diameter (AD) to predict dysmenorrhea (VAS ≥ 4) and the diagnosis of adenomyosis were determined by receiver operating characteristic curves.ResultsThere were 220 patients with and 233 patients without EM included. Uterine AD independently correlated with the VAS scores in patients with (B = .230, P = .000) and without (B = .203, P = .000) EM. A uterine AD of 39.5 mm predicted dysmenorrhea in both groups. The presence of EM increased the VAS scores by 1.151 points when controlling for uterine diameters. Uterine AD also independently correlated with the diagnosis of adenomyosis under TVS in patients with (OR = 1.212, 95% CI = 1.130–1.301; P = .000) and without (OR = 1.192, 95% CI = 1.123–1.263; P = .000) EM. A uterine AD of 38.5 and 39.5 mm predicted the diagnosis of adenomyosis under TVS in patients with and without EM, respectively.ConclusionsIncreased uterine AD, which is probably ascribed to adenomyosis, plays an important role in augmented menstrual abdominal pain intensity. Meanwhile, the presence of EM reinforces the pain.
Accelerated and quantitative three‐dimensional molecular MRI using a generative adversarial network
Authors: Weigand‐Whittier Jonah , Sedykh Maria , Herz Kai , Coll‐Font Jaume , Foster Anna N. , Gerstner Elizabeth R. , Nguyen Christopher , Zaiss Moritz , Farrar Christian T. , Perlman Or 
Published: December 2022

PurposeTo substantially shorten the acquisition time required for quantitative three‐dimensional (3D) chemical exchange saturation transfer (CEST) and semisolid magnetization transfer (MT) imaging and allow for rapid chemical exchange parameter map reconstruction.MethodsThree‐dimensional CEST and MT magnetic resonance fingerprinting (MRF) datasets of L‐arginine phantoms, whole‐brains, and calf muscles from healthy volunteers, cancer patients, and cardiac patients were acquired using 3T clinical scanners at three different sites, using three different scanner models and coils. A saturation transfer‐oriented generative adversarial network (GAN‐ST) supervised framework was then designed and trained to learn the mapping from a reduced input data space to the quantitative exchange parameter space, while preserving perceptual and quantitative content.ResultsThe GAN‐ST 3D acquisition time was 42–52 s, 70% shorter than CEST‐MRF. The quantitative reconstruction of the entire brain took 0.8 s. An excellent agreement was observed between the ground truth and GAN‐based L‐arginine concentration and pH values (Pearson's r > 0.95, ICC > 0.88, NRMSE < 3%). GAN‐ST images from a brain‐tumor subject yielded a semi‐solid volume fraction and exchange rate NRMSE of and , respectively, and SSIM of and , respectively. The mapping of the calf‐muscle exchange parameters in a cardiac patient, yielded NRMSE < 7% and SSIM > 94% for the semi‐solid exchange parameters. In regions with large susceptibility artifacts, GAN‐ST has demonstrated improved performance and reduced noise compared to MRF.ConclusionGAN‐ST can substantially reduce the acquisition time for quantitative semi‐solid MT/CEST mapping, while retaining performance even when facing pathologies and scanner models that were not available during training.
Nonlinear stochastic dynamics research on a Lorenz system with white Gaussian noise based on a quasi‐potential approach
Authors: Huang Yong 
Published: December 2022

AbstractEnvironmental noise can lead to complex stochastic dynamical behaviors in nonlinear systems. In this paper, a Lorenz system with the parameter region with two stable fixed points and a chaotic saddle subject to white Gaussian noise is investigated as an example. Noise‐induced phenomena, such as noise‐induced quasi‐cycle, three‐state intermittency, and chaos, are observed. In the intermittency process, the optimal path used to describe the transition mechanism is calculated and confirmed to pass through an unstable periodic orbit, a chaotic saddle, a saddle point, and a heteroclinic trajectory in an orderly sequence using generalized cell mapping with a digraph method constructively. The corresponding optimal fluctuation forces are delineated to uncover the effects of noise during the transition process. Then the process will switch frequently between the attractors and the chaotic saddle as noise intensity increased further, that is, noise induced chaos emerging. A threshold noise intensity is defined by stochastic sensitivity analysis when a confidence ellipsoid is tangent to the stable manifold of the periodic orbit, which agrees with the simulation results. It is finally reported that these results and methods can be generalized to analyze the stochastic dynamics of other nonlinear mechanical systems with similar structures.
Stretch‐induced wrinkling analysis of thin sheets with splines
Authors: Tian Haitao , Chen Lin , Li Bin 
Published: December 2022

SummaryNumerical simulation of stretch‐induced wrinkling in thin elastic sheets is a challenging problem due to a vanishing bending stiffness and the coexistence of superabundant equilibrium solutions. In this work, we present a computational framework to capture the morphological evolution of stretch‐induced wrinkles. The application of modified Föppl‐von Kármán plate model results in a fourth‐order partial differential equation. The convergence of finite‐element solutions necessitates ‐continuous approximations. Herein, Powell‐Sabin B‐splines, which are based on triangles, are utilized for both the approximation of the field variables and the description of the geometry. To trace the wrinkling behavior in thin sheets, a path‐following technique using asymptotic numerical method is considered. The advantage of this method is an adaptive step length, which works incredibly well near the bifurcation points and allows for the computation of the post‐bifurcation diagrams with a quite small perturbation. The versatility and accuracy of the developed computational approach are assessed in three case studies, featuring wrinkling in highly stretched rectangular and annular thin sheets.
Improved Tucker decomposition algorithm for noise suppression of 3D GPR data in road detection
Authors: Yan Kun , Zhang Zhihua , Xu Xianlei 
Published: December 2022

AbstractThe echo data of ground‐penetrating radar (GPR) have a low signal‐to‐noise ratio. Denoising and interference suppression are important for improving the accuracy of underground target recognition and detection. In this paper, a new method of noise analysis and suppression of 3D GPR is proposed, transforming the problem of noise reduction into an optimization problem regarding a third‐order tensor. This method is improved with the following features; a bidimensional empirical mode decomposition (BEMD) algorithm is employed to decompose the 3D GPR noise. The main source of the noise is determined by computing the standard deviation of each component decomposed. For the shortcoming of the existing GPR denoising methods that reduce the dimension of 3D GPR data, the proposed approach can denoise 3D GPR data directly to avoid the loss of data caused by reducing the dimension. This preserves the desired signal and extracts noise through the Tucker decomposition of 3D GPR data. An improved high‐order orthogonal iteration algorithm is utilized to optimize the decomposition. The peak signal‐to‐noise ratio (PSNR) of the signal for each survey line is calculated to evaluate the effectiveness of noise reduction. Simulations and real data sets are provided to compare the performance of algorithms. The results show that the mean PSNR after noise suppression with our method is 8.915 dB and 16.458 dB higher than wavelet transform and singular value decomposition algorithms, respectively. This demonstrates that the proposed approach can better suppress 3D GPR noise and provides technical support for improving 3D GPR data quality and road detection accuracy.
Natural transform decomposition method for the numerical treatment of the time fractional Burgers–Huxley equation
Authors: Ravi Kanth Adivi Sri Venkata , Aruna Kirubanandam , Raghavendar Kondooru 
Published: December 2022

AbstractIn this article, we studied the time‐fractional Burgers–Huxley equation using the natural transform decomposition method. The fractional operator is treated in the Caputo, Caputo–Fabrizio, and Atangana–Baleanu senses. We employed the natural transform with the Adomian decomposition process on time‐fractional Burgers–Huxley equation to obtain the solution. To establish the uniqueness and convergence of the accomplished solution, the Banach's fixed point theorem is used. The obtained findings are visually shown in two‐ and three‐dimensional graphs for various fractional orders. To illustrate the efficacy of the method under discussion, numerical simulations are provided. The proposed solution captures the behavior of the reported findings for various fractional orders. A comparative study was conducted to ascertain the proposed method's correctness. The findings of this study establish that the technique investigated is both efficient and accurate for solving nonlinear fractional differential equations that arise in science and technology.
Low‐cost polysulfone/polystyrene ultrafiltration membrane with efficient azoic dyes removal and excellent antifouling performance for colored wastewater
Authors: Essate Ahlam , Achiou Brahim , Benkhaya Said , Chakraborty Sudip , Ouammou Mohamed , Alami Younssi Saad 
Published: December 2022

AbstractA new low‐cost composite ultrafiltration membrane made of polysulfone (PSf) and polystyrene (PS) blend was effectively achieved on the ceramic pozzolan support using dip‐coating method. The effect of PS content (5–20 wt%) on membrane properties such as microstructure and filtration performances was investigated. The Fourier‐transform infrared spectroscopy, nuclear magnetic resonance, and differential scanning calorimetry analyses confirm that the two polymers lead to physical blend. The morphology analysis shows that PSf/PS membrane layer is homogeneous and strongly adherent on the pozzolan support. Furthermore, the developed membrane was applied for filtration of direct red (DR80) and methyl orange (MO) solutions at a pressure of 3 bar. It was proven that the PS addition significantly enhances the rejection of the membrane companying with a decrease of permeate flux to meet the trade‐off selectivity‐permeability. The optimized PSf/PS membrane containing 5 wt% of PS has a water permeability of 24 L h−1 m−2 bar−1, and could reject 91% and 76%, respectively for DR80 and MO. Beside the promising filtration results, the developed membrane is also low‐cost thanks to using pozzolan support, and it could be consequently scaled up for the treatment of colored wastewater generated from textile industries.
Is anticholinergic and sedative drug burden associated with postdischarge institutionalization in community‐dwelling older patients acutely admitted to hospital? A Norwegian registry‐based study
Authors: Havnes Kjerstin , Svendsen Kristian , Johansen Jeanette Schultz , Granas Anne Gerd , Garcia Beate Hennie , Halvorsen Kjell H. 
Published: December 2022

AbstractPurposeInvestigate the association between anticholinergic (AC) and sedative (SED) drug burden before hospitalization and postdischarge institutionalization (PDI) in community‐dwelling older patients acutely admitted to hospital.MethodsA cross‐sectional study using data from the Norwegian Patient Registry and the Norwegian Prescription Database. We studied acutely hospitalized community‐dwelling patients ≥70 years during 2013 (N = 86 509). Patients acutely admitted to geriatric wards underwent subgroup analyses (n = 1715). We calculated drug burden by the Drug Burden Index (DBI), use of AC/SED drugs, and the number of AC/SED drugs. Piecewise linearity of DBI versus PDI and a knot point (DBI = 2.45) was identified. Statistical analyses included an adjusted multivariable logistic regression model.ResultsIn the total population, 45.4% were exposed to at least one AC/SED drug, compared to 52.5% in the geriatric subgroup. AC/SED drugs were significantly associated with PDI. The DBI with odds ratios (ORs) of 1.11 (95% CI 1.07–1.15) for DBI < 2.45 and 1.08 (95% CI 1.04–1.13) for DBI ≥ 2.45. The number of AC/SED drugs with OR of 1.07 (95% CI 1.05–1.09). The AC component of DBI with OR 1.23 and the number of AC drugs with OR 1.13. In the subgroup, ORs were closer to 1 for AC drugs.ConclusionsThe use of AC/SED drugs was highly prevalent in older patients before acute hospital admissions, and significantly associated with PDI. The number, or just using AC/SED drugs, gave similar associations with PDI compared to applying the DBI. Using AC drugs showed higher sensitivity, indicating that to reduce the risk of PDI, a clinical approach could be to reduce the number of AC drugs.
Live‐cell super‐resolution imaging of actin using LifeAct‐14 with a PAINT‐based approach
Authors: Bhaskar Haresh , Kleinjan Dirk‐Jan , Oi Curran , Gidden Zoe , Rosser Susan J. , Horrocks Mathew H. , Regan Lynne 
Published: December 2022

AbstractWe present direct‐LIVE‐PAINT, an easy‐to‐implement approach for the nanoscopic imaging of protein structures in live cells using labeled binding peptides. We demonstrate the feasibility of direct‐LIVE‐PAINT with an actin‐binding peptide fused to EGFP, the location of which can be accurately determined as it transiently binds to actin filaments. We show that direct‐LIVE‐PAINT can be used to image actin structures below the diffraction‐limit of light and have used it to observe the dynamic nature of actin in live cells. We envisage a similar approach could be applied to imaging other proteins within live mammalian cells.
Exploring the mechanisms underlying the toxicity of boric acid against the land snail, Theba pisana
Authors: Radwan Mohamed A , Gad Amira F 
Published: December 2022

AbstractBACKGROUNDThe land snail, Theba pisana, is one of the most important threats facing agriculture around the globe. Boric acid (BOA) is currently used as a safe alternative molluscicide to control land snails in sustainable agriculture, but the mechanisms of toxicity have not yet been investigated. The present study characterizes the lethal and sub‐lethal (0.5 and 1 mg g−1) toxic effects of BOA‐contaminated food for 14 days by examining physiological, biochemical and histopathological indicators in T. pisana to understand the mechanisms underlying its toxic action.RESULTSBOA was found to be lethal against T. pisana with LC50 values of 24.7 and 8.05 mg g−1 after 3 and 7 days of exposure, respectively. BOA sublethal concentrations led to a significant reduction in food consumption and growth of snails after 14 days of exposure. BOA also caused a significant increase in testosterone levels, whereas an opposite effect was observed in estradiol levels. An increase in progesterone levels in snails in the 0.5 mg g−1 BOA group and a decrease in the 1 mg g−1 BOA group were observed after all exposure times. Moreover, the lipid peroxidation level and catalase activity were elevated, whereas acetylcholinesterase activity was inhibited in the treated snails. Alteration in glutathione‐S‐transferase activity was noticed after exposure to both sublethal concentrations. In addition, BOA induced histopathological alterations in the digestive gland of T. pisana.CONCLUSIONOur findings provide novel insights into how physiological, biochemical and histopathological alterations can be used to explore the mechanisms underlying BOA toxicity against snails. © 2022 Society of Chemical Industry.
An improved score‐type confidence interval for stratified risk differences involving rare events
Authors: Hu Yetao , Lu Kaifeng , Xie Lei , Zhu Wei 
Published: December 2022

AbstractA stratified analysis of the differences in proportions has been widely employed in epidemiological research, social sciences, and drug development. It provides a useful framework for combining data across strata to produce a common effect. However, for rare events with incidence rates close to zero, popular confidence intervals for risk differences in a stratified analysis may not have appropriate coverage probabilities that approach the nominal confidence levels and the algorithms may fail to produce a valid confidence interval because of zero events in both the arms of a stratum. The main objective of this study is to evaluate the performance of certain methods commonly employed to construct confidence intervals for stratified risk differences when the response probabilities are close to a boundary value of zero or one. Additionally, we propose an improved stratified Miettinen–Nurminen confidence interval that exhibits a superior performance over standard methods while avoiding computational difficulties involving rare events. The proposed method can also be employed when the response probabilities are close to one.