bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosing Mild Forms of Anorectal Malformation With Anorectal Manometry: A Prospective Study
Authors: den Hollander Venla E.C. , Gerritsen Steffie , van Dijk Tonnis H. , Trzpis Monika , Broens Paul M.A. 
Published: December 2022

INTRODUCTION:
Rectoperineal congenital anorectal malformations (CARMs) are diagnosed by examining the perineum, combined with electric stimulation (ES) of the anal sphincter performed under anesthesia. This procedure may be troublesome because it is based on the observed contractibility of the sphincter. We aimed to add 3-dimensional high-resolution anorectal manometry (3D-HRAM) to the procedure and to assess its value for diagnosing rectoperineal forms of CARM.

METHODS:
We prospectively included 66 patients younger than 24 months who presented with constipation and were suspected of CARM, idiopathic constipation, or Hirschsprung disease. The patients were assessed between 2015 and 2021 at University Medical Center Groningen, the Netherlands. All patients underwent 3D-HRAM, followed by the standard diagnostic procedure for either CARM or Hirschsprung disease.

RESULTS:
Of the 51 patients who underwent both 3D-HRAM and ES, we observed that patients with rectoperineal CARM revealed a pressure gap along the anterior part of the anal sphincter. Based on this observation, we diagnosed 35 patients with CARM. Subsequently, all 35 diagnoses were confirmed with ES. Sixteen patients were diagnosed as not having CARM, 100% of whom were in agreement with the gold standard—ES. Both the specificity and sensitivity of 3D-HRAM for diagnosing rectoperineal CARM were 100%.

DISCUSSION:
We consider 3D-HRAM a reliable tool for diagnosing and excluding rectoperineal CARM. Using this method in patients suspected of CARM might keep infants from undergoing unnecessary interventions requiring anesthetics, such as ES. By providing objective insight into the functional capabilities of the anal sphincter, anorectal manometry adds to the diagnosis.
Silencing TLR4 using an ultrasound-targeted microbubble destruction-based shRNA system reduces ischemia-induced seizures in hyperglycemic rats
Authors: Chen Jia , Huang Fami , Fang Xiaobo , Li Siying , Liang Yanling 
Published: December 2022

Abstract
The toll-like receptor 4 (TLR4) pathway is involved in seizures. We investigated whether ultrasound-targeted microbubble destruction (UTMD)-mediated delivery of short hairpin RNA (shRNA) targeting the TLR4 gene (shRNA-TLR4) can reduce ischemia-induced seizures in rats with hyperglycemia. A total of 100 male Wistar rats were randomly assigned to five groups: (1) Sham; (2) normal saline (NS); (3) shRNA-TLR4, where rats were injected with shRNA-TLR4; (4) shRNA-TLR4 + US, where rats were injected with shRNA-TLR4 followed by ultrasound (US) irradiation; and (5) shRNA-TLR4 + microbubbles (MBs) + US, where rats were injected with shRNA-TLR4 mixed with MBs followed by US irradiation. Western blot and immunohistochemical staining were used to measure TLR4-positive cells. Half of the rats in the NS group developed tonic-clonic seizures, and TLR4 expression in the CA3 region of the hippocampus was increased in these rats. In addition, the NS group showed an increased number of TLR4-positive cells compared with the Sham group, while there was a decreased number of TLR4-positive cells in the shRNA, shRNA + US, and shRNA + MBs + US groups. Our findings indicate that the TLR4 pathway is involved in the pathogenesis of ischemia-induced seizures in hyperglycemic rats and that UTMD technology may be a promising strategy to treat brain diseases.
GraphML-SBGN bidirectional converter for metabolic networks
Authors: Balaur Irina , Roy Ludovic , Touré Vasundra , Mazein Alexander , Auffray Charles 
Published: December 2022

Abstract
Systems biology researchers need feasible solutions for editing and visualisation of large biological diagrams. Here, we present the ySBGN bidirectional converter that translates metabolic pathways, developed in the general-purpose yEd Graph Editor (using the GraphML format) into the Systems Biology Graphical Notation Markup Language (SBGN-ML) standard format and vice versa. We illustrate the functionality of this converter by applying it to the translation of the ReconMap resource (available in the SBGN-ML format) to the yEd-specific GraphML and back. The ySBGN tool makes possible to draw extensive metabolic diagrams in a powerful general-purpose graph editor while providing results in the standard SBGN format.
Implementation of 10 Gbps optical wireless link for 200 km inter-aircraft optical communications
Authors: Sudhakar Muppidi Venkata , Rajini Gaddam Kesava Reddy 
Published: December 2022

Abstract
The enhancements related to optical devices are highly required for high-speed compact wireless optical transmission systems. This paper focuses on development and analysis of the communication system for inter-aircraft applications. The vertical cavity surface emitting laser (VCSEL) is employed at the transmitter for generating directly modulated non-return to zero (NRZ) signal. Direct detection along with Gaussian low pass filtering is employed in the receiver. The performance of the system is examined as well as compared with and without application of filtering at the receiver. The performance of optical wireless system is analyzed in terms of BER, eye-pattern, sensitivity, SNR, and Q-factor. The data rate is enhanced by 4-fold and transmission distance is improved by 250% in comparison with earlier inter-satellite links.
Wet tropospheric correction for satellite altimetry using SIRGAS-CON products
Authors: Prado Anderson , Vieira Telmo , Pires Nelson , Fernandes Maria Joana 
Published: December 2022

Abstract
The wet tropospheric correction (WTC) is a required correction to satellite altimetry measurements, mainly due to the atmospheric water vapor delay. On-board microwave radiometers (MWR) provide information for WTC estimation but fail in coastal zones and inland waters. In view to recover the WTC in these areas, the Global Navigation Satellite System (GNSS)-derived Path Delay Plus (GPD+) method, developed by the University of Porto, uses Zenith Tropospheric Delays from GNSS global and regional networks’ stations combined with other sources of information, providing a WTC solution for all along-track altimeter points. To densify the existing dataset used by GPD+, it is necessary to add new GNSS stations, mainly in the southern hemisphere, in regions such as South America, Africa and Oceania. This work aims to exploit the SIRGAS-CON data and its potential for densification of the GPD+ input dataset in Latin America and to improve GPD+ performance. The results for the three analyzed satellites (Sentinel-3A, Sentinel-3B and CryoSat-2) show that, when compared with the WTC from GNSS and radiosondes, the densified GPD+ WTC leads to a reduction in the RMS of the WTC differences with respect to the non-densified GPD+ solution, up to 2 mm for the whole region and up to 5 mm in some locations.
Structural characterization of fillers of inorganic materials in bismaleimide resins
Authors: Dash Ritambhara , Kommu Parameshwar , Kumari Neha , Bhattacharyya Arnab S. 
Published: December 2022

Abstract
Because of its dimensional stability, minimal shrinkage, chemical and fire resistance, good mechanical qualities and high resistance to a variety of solvents, acids and water, bismaleimide (BMI) thermosetting polymers are mostly employed in aerospace applications. Corrosion prevention has also been accomplished using BMI coating. The addition of inorganic materials like metal oxides can influence the properties of BMI as an inorganic–organic composite. Ferric chloride–bismaleimide (FeCl3–BMI) and titania–bismaleimide (TiO2–BMI) composites were synthesized. Fillers of inorganic compounds like MnO2, Ni (NO3)2·6H2O and Al2(SO4)3 were synthesized as well. The structural and crystalline configuration as well as physicochemical changes were thoroughly studied by XRD and Fourier transform infrared spectroscopy (FTIR).
Effect of spraying polyvinyl alcohol solution on the surface of liquid film on the structure and antifouling properties of polyvinylidene membrane
Authors: Xu Lang , Wang Chenyang , Shuai Qi , Li Hongjun , Zhang Hongwei , Zuo Danying 
Published: December 2022

Abstract
Polyvinylidene fluoride (PVDF) membrane was prepared by a two-step method of surface gelation-immersion precipitation. The surface of the scraping solution film was sprayed with polyvinyl alcohol (PVA) aqueous solution to gel the film surface first, and then the liquid film was immersed in a coagulation bath for phase transformation to obtain the surface modified PVDF membrane. The effects of PVA solution with different mass fraction on the structure and properties of PVDF membrane were studied. The results showed that with the increase of spraying PVA mass fraction, the contact angle of the upper surface of PVDF membranes gradually decreased, the porosity and mean pore size of PVDF membranes gradually increased, and the crystallinity of PVDF membranes gradually decreased. The pores on upper surface of the membranes first increased and then decreased, and the finger-like macropore structure appeared inside the membranes, the water flux first increased and then decreased, and the rejection rate increased. Dynamic cycle filtration experiment of bovine serum protein (BSA) solution showed an increase in membrane flux recovery from 68.31 to 95.08% and a decrease in the irreversible fouling rate from 31.69 to 4.92%, indicating an improvement in the hydrophilicity and antifouling properties of the modified PVDF membrane.
Delivery systems in nanocosmeceuticals
Authors: Martel-Estrada Santos-Adriana , Morales-Cardona Andrea-Isabel , Vargas-Requena Claudia-Lucía , Rubio-Lara Juan-Antonio , Martínez-Pérez Carlos-Alberto , Jimenez-Vega Florinda 
Published: December 2022

Abstract
Today, the growth of the cosmetic industry and dramatic technological advances have led to the creation of functional cosmetical products that enhance beauty and health. Such products can be defined as topical cosmetic drugs to improve health and beauty functions or benefits. Implementing nanotechnology and advanced engineering in these products has enabled innovative product formulations and solutions. The search included organic molecules used as cosmeceuticals and nanoparticles (NPs) used in that field. As a result, this document analyses the use of organic and inorganic particles, metals, metal-oxides, and carbon-based particles. Additionally, this document includes lipid and nanoparticles solid lipid systems. In conclusion, using NPs as vehicles of active substances is a potential tool for transporting active ingredients. Finally, this review includes the nanoparticles used in cosmeceuticals while presenting the progress made and highlighting the hidden challenges associated with nanocosmeceuticals.
A Layered, Hybrid Machine Learning Analytic Workflow for Mouse Risk Assessment Behavior
Authors: Wang Jinxin , Karbasi Paniz , Wang Liqiang , Meeks Julian P. 
Published: December 2022

AbstractAccurate and efficient quantification of animal behavior facilitates the understanding of the brain. An emerging approach within machine learning (ML) field is to combine multiple ML-based algorithms to quantify animal behavior. These so-called hybrid models have emerged because of limitations associated with supervised [e.g., random forest (RF)] and unsupervised [e.g., hidden Markov model (HMM)] ML models. For example, RF models lack temporal information across video frames, and HMM latent states are often difficult to interpret. We sought to develop a hybrid model, and did so in the context of a study of mouse risk assessment behavior. We used DeepLabCut to estimate the positions of mouse body parts. Positional features were calculated using DeepLabCut outputs and were used to train RF and HMM models with equal number of states, separately. The per-frame predictions from RF and HMM models were then passed to a second HMM model layer (“reHMM”). The outputs of the reHMM layer showed improved interpretability over the initial HMM output. Finally, we combined predictions from RF and HMM models with selected positional features to train a third HMM model (“reHMM+”). This reHMM+ layered hybrid model unveiled distinctive temporal and human-interpretable behavioral patterns. We applied this workflow to investigate risk assessment to trimethylthiazoline and snake feces odor, finding unique behavioral patterns to each that were separable from attractive and neutral stimuli. We conclude that this layered, hybrid ML workflow represents a balanced approach for improving the depth and reliability of ML classifiers in chemosensory and other behavioral contexts.
Cytosolic stress granules relieve the ubiquitin‐proteasome system in the nuclear compartment
Authors: Xu Shanshan , Gierisch Maria E , Schellhaus Anna Katharina , Poser Ina , Alberti Simon , Salomons Florian A , Dantuma Nico P 
Published: December 2022

AbstractThe role of cytosolic stress granules in the integrated stress response has remained largely enigmatic. Here, we studied the functionality of the ubiquitin‐proteasome system (UPS) in cells that were unable to form stress granules. Surprisingly, the inability of cells to form cytosolic stress granules had primarily a negative impact on the functionality of the nuclear UPS. While defective ribosome products (DRiPs) accumulated at stress granules in thermally stressed control cells, they localized to nucleoli in stress granule‐deficient cells. The nuclear localization of DRiPs was accompanied by redistribution and enhanced degradation of SUMOylated proteins. Depletion of the SUMO‐targeted ubiquitin ligase RNF4, which targets SUMOylated misfolded proteins for proteasomal degradation, largely restored the functionality of the UPS in the nuclear compartment in stress granule‐deficient cells. Stress granule‐deficient cells showed an increase in the formation of mutant ataxin‐1 nuclear inclusions when exposed to thermal stress. Our data reveal that stress granules play an important role in the sequestration of cytosolic misfolded proteins, thereby preventing these proteins from accumulating in the nucleus, where they would otherwise infringe nuclear proteostasis.
DNA damage repair kinase DNA‐PK and cGAS synergize to induce cancer‐related inflammation in glioblastoma
Authors: Taffoni Clara , Marines Johanna , Chamma Hanane , Guha Soumyabrata , Saccas Mathilde , Bouzid Amel , Valadao Ana‐Luiza Chaves , Maghe Clément , Jardine Jane , Park Mi Kyung , Polak Katarzyna , De Martino Mara , Vanpouille‐Box Claire , Del Rio Maguy , Gongora Celine , Gavard Julie , Bidère Nicolas , Song Min Sup , Pineau Donovan , Hugnot Jean‐Philippe , Kissa Karima , Fontenille Laura , Blanchet Fabien P , Vila Isabelle K , Laguette Nadine 
Published: December 2022

AbstractCytosolic DNA promotes inflammatory responses upon detection by the cyclic GMP‐AMP (cGAMP) synthase (cGAS). It has been suggested that cGAS downregulation is an immune escape strategy harnessed by tumor cells. Here, we used glioblastoma cells that show undetectable cGAS levels to address if alternative DNA detection pathways can promote pro‐inflammatory signaling. We show that the DNA‐PK DNA repair complex (i) drives cGAS‐independent IRF3‐mediated type I Interferon responses and (ii) that its catalytic activity is required for cGAS‐dependent cGAMP production and optimal downstream signaling. We further show that the cooperation between DNA‐PK and cGAS favors the expression of chemokines that promote macrophage recruitment in the tumor microenvironment in a glioblastoma model, a process that impairs early tumorigenesis but correlates with poor outcome in glioblastoma patients. Thus, our study supports that cGAS‐dependent signaling is acquired during tumorigenesis and that cGAS and DNA‐PK activities should be analyzed concertedly to predict the impact of strategies aiming to boost tumor immunogenicity.
PERANAN GREEN SOCIAL WORKERS PADA PROGRAM KAMPUNG IKLIM DI WILAYAH PESISIR INDONESIA
Authors: Ramdani Jaka , Gunawan Budhi , Darwis Rudi Saprudin 
Published: December 2022

Abstract. Climate change currently threatens 60 percent of Indonesia's total population residing in coastal areas at risk of land inundation due to sea level rise. Based on IPCC predictions, the coastal area of Ujungalang Village, Cilacap Regency, Central Java Province, will be affected. Efforts to increase adaptation to the impacts of climate change through the Climate Village Program are an alternative to minimize impacts. Uniquely, the empowerment program refers to Green Social Work which involves multi-parties such as Green Social Workers, Professions or experts (transdisciplinary), communities, and partnerships. Therefore, through this research, the role of Green Social Work in the Climate Village Program can be explored with a case study in Ujungalang Village, Cilacap Regency. The role of Green Social Workers is presented using qualitative data sourced from primary and secondary data. The in-depth interview process, semi-participant observations, and literature studies obtained research findings that Green Social Workers in the Climate Village Program played roles as Co-producers, Dialogue agents, Lobbyists, Coordinators, Translators, Curriculum changers, Mobilisers, screenwriters, Protectors, Consciousness-raisers. Through the role carried out by Green Social Workers in the Climate Village Program, it shows the success of a sustainable program for the people of Ujungalang Village. Keywords: Climate Village, Green Social Workers, Role. Abstrak. Perubahan iklim saat ini mengancam 60 persen dari total penduduk Indonesia yang bertempat tinggal di wilayah pesisir risiko tergenangnya daratan akibat kenaikan muka air laut. Berdasarkan prediksi IPCC wilayah pesisir Desa Ujungalang Kabupaten Cilacap Provinsi Jawa Tengah akan terkena dampaknya. Upaya peningkatan adaptasi dampak perubahan iklim melalui Program Kampung Iklim menjadi alternatif meminimalisir dampak. Uniknya program pemberdayaan tersebut merujuk pada Green Social Work yang melibatkan multi pihak seperti Green Social Worker, Profesi atau ahli (transdisiplin), masyarakat, dan kemitraan. Oleh karenanya, melalui penelitian ini dapat tereksplorasi peranan Green Social Work pada Program Kampung Iklim dengan studi kasus di Desa Ujungalang Kabupaten Cilacap. Peranan Green Social Worker disajikan menggunakan data kualitatif yang bersumber dari data primer maupun sekunder. Proses wawancara mendalam, observasi semi partisipan, dan studi kepustakaan memperoleh temuan penelitian bahwa Green Social Worker di Program Kampung iklim berperan sebagai Co-producers, Dialogue agents, Lobbyists, Coordinator, Translators, Curriculum changers, Mobilisers, pembuat skenario, Protectors, Consciousness-raisers. Melalui peranan yang dilakukan oleh Green Social Worker di Program Kampung Iklim menunjukan keberhasilan program yang berkelanjutan bagi masyarakat Desa Ujungalang. Kata kunci: Peranan, Green Social Workers, Kampung Iklim.
Research of the round convective air jet of the exhaust local ventilation
Authors: Voznyak Orest , Spodyniuk Nadiia , Dovbush Oleksandr , Savchenko Olena , Sukholova Iryna , Kasynets Mariana , Kirakevych Iryna 
Published: December 2022

AbstractThe article is devoted to research of properties of the round convective air jet. The aim of this work is to establish universal graphical dependencies and empirical formulas for describing velocity and temperature fields over the entire range of development of round convective exhaust ventilation jet; development of an algorithm for solving the transcendent problem of determining the surface temperature of a heat source; introduction of velocity and temperature attenuation coefficients for round convective jet; visualization of its characteristics in the form of a 3D image; achieving reduction of metal consumption of the local exhaust ventilation system due to the overall optimization of the velocity and temperature fields of the round convective air jet.
Rachunkowość w realizacji potrzeb ekonomiczno-społecznych w aspekcie koncepcji zrównoważonego rozwoju. Doświadczenia z projektów szkoleniowych w systemie ochrony zdrowia
Authors: Baran Wioletta 
Published: December 2022

Objective: To examine the impact of accounting on economic and social needs, including the management needs of medical entities terms seeking sustainable development, on the example of training and research projects.Research Design & Methods: Accounting is described from the perspective of sustainable development, thanks to the information, educational and application capabilities of this system. Participatory observation, critical analysis and synthesis are used.Findings: Monitored and controlled activities in training and research projects were adjusted to the needs of healthcare entities, making it possible to achieve the anticipated impact on the economic and social environment. The accounting system is shown to be flexible, and thus it is used in the creation of decision-making bases for actions taken for sustainable development.Implications / Recommendations: The use of feedback activity appropriate for the operation of information systems, including the accounting system under consideration, makes educational and application possibilities of accounting a real response to the growing economic and social needs of stakeholders. Education in accounting falls within the category of high-quality education – that is, education that combines knowledge and skills and flexibly responds to economic and social needs, including the management needs of healthcare entities.Contribution: The use of universal features of the accounting system, but above all its informational, educational, and application capabilities in response to correctly identified economic and social needs of various types, including types of entities, will determine the shape of an effective accounting system. Effectiveness will mean it is successfully used in the preparation of applicable information for making all kinds of decisions, including those that contribute to sustainable development.
Сomparison of Au, Au-Pt, and Au-Ag nanoparticles as markers for immunochromatographic determination of nonylphenol
Authors: Berlina Anna N. , Ragozina Maria Y. , Komova Nadezhda S. , Serebrennikova Kseniya V. , Zherdev Anatoly V. , Dzantiev Boris B. 
Published: December 2022

Gold spherical nanoparticles, gold-platinum nanoflowers, and gold-silver nanostars were obtained and compared as labels for immunochromatographic analysis. The nanoparticles were synthesized by chemical reduction from various precursors and then conjugated with staphylococcal protein A to be used in indirect immunochromatographic determination of nonylphenol. The results obtained were evaluated in terms of analytical characteristics and R2 value, as well as the color intensity of the test band. According to the comparison results, it was revealed that the R2 value varied from 0.82 for the gold-silver nanostars to 0.96 for the spherical gold nanoparticles. The working range of determined concentrations was from 2 to 100 μg/mL for unspherical and from 2 to 50 μg/mL – for spherical markers used; the analysis time was 20 min.
De la filosofía sensista observacional al drama neoclásico; el caso de María Rita de Barrenechea y Tomás de Iriarte
Authors: Cantero García Víctor 
Published: December 2022

Dos son las cuestiones que se dilucidan en el presente artículo. De un lado, pretendemos demostrar que los principios de la filosofía sensista observacional impregnan la composición de dos dramas neoclásicos: La Aya, de María Rita de Barrenechea y La señorita malcriada, de Tomás de Iriarte, a la par que inciden en la técnica realista con la que sendos autores redactan sus comedias. De otro, intentamos dilucidar hasta qué punto puede considerarse La Aya un antecedente de La señorita malcriada y si en ésta Iriarte supera a María Rita de Barrenechea en el uso acertado de los recursos dramáticos.