bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulation of Biophysical Cues in Nature Inspired Patterning of Porous Silk Fibroin Scaffold for Replenishable Controlled Drug Delivery
Authors: Mukhopadhyay Anurup , Gope Ayan , Choudhury Kabita , Chatterjee Jyotirmoy , Mukherjee Rabibrata 
Published: June 2023

AbstractWhile a sticking plasteris enough for healing of most of the minor cuts they may get routinely, critical situations like surgical, gunshot, accidental or diabetic wounds;lacarations and other cutaneous deep cuts may require implants and simultaneous medications for healing. From the biophysical standpoint, an internal force‐based physical surface stimulusis crucial for cellular sensing during wound repair. In this paper, the authors report the fabrication of a porous, biomimmetically patterned silk fibroin scaffold loaded with ampicillin, which exhibits controlled release of the drug along with possible replenishment of the same. In vitro swelling study reveals that the scaffolds with hierarchical surface patterns exhibit lower swelling and degradation than other types of scaffolds. The scaffolds, that show remarkable broad–spectrum antibacterial efficacy, exhibit Korsemeyer–Peppas model for the ampicillin release patterns due to the structural hydrophobicity imparted by the patterns. Four distinct cell‐matrix adhesion regimes are investigated for the fibroblasts to eventually form cell sheets all over the hierarchical surface structures. 4',6–diamidino–2–phenylindole (DAPI) and Fluorescein Diacetate (FDA) fluorescent staining clearly demonstrate the superiority of patterned surface over its other variants. A comparative immunofluorescence study among collagen I, vinculin, and vimentin expressions substantiated the patterned surface to be superior to others.
Change in company leadership, subordinate executive team restructuring, and investment efficiency
Authors: Li Yaoyao , Wang Tianmei 
Published: June 2023

AbstractUnder the Chinese corporate governance model, the change of “leader” is one of the most significant occurrences for a company, and there is a strong relationship between “leaders”(chairman and CEO) and the executive team under them. Using data from listed A‐share businesses in China from 2007 to 2018, this study evaluates the effects of leaders' changes on investment efficiency and the effects of subordinate executive team restructuring caused by “leadership” change on investment efficiency. The findings reveal that the change of “leaders” significantly reduces company's investment efficiency, and the greater the degree of restructuring of subordinate executives caused by the change of “leaders”, the greater the negative impact on the company's investment efficiency. Nevertheless, the successor leader with a financial background can well mitigate the negative impact of the subordinate executive team restructuring on investment efficiency. In further analysis, we discover that the subordinate executive reorganization results in both overinvestment and underinvestment. However, state‐owned enterprises are more resilient to the damaging impacts of organizational shocks. Additionally, a good internal and external regulatory mechanism can mitigate the negative impact of the subordinate executive teams restructuring on investment efficiency. In conclusion, this study provides scientific support for improving executive team management and optimizing investment decisions for companies.
Development and validation of models predicting treatment patterns in women with urinary urgency and/or urgency incontinence: A Symptoms of Lower Urinary Tract Dysfunction Research Network observational cohort study
Authors: Bretschneider Carol Emi , Liu Qian , Smith Abigail R. , Mansfield Sarah A. , Kirkali Ziya , Amundsen Cindy L. , Lai Hing Hung Henry , Geynisman‐Tan Julia , Kirby Anna , Jelovsek John Eric ,   the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study Group
Published: June 2023

AbstractPurposeTo develop a tool to predict a woman's treatment pattern for bothersome urinary urgency (UU) and/or UU incontinence over 1 year after presenting for care at urology or urogynecology clinics.MethodsThe Symptoms of Lower Urinary Tract Dysfunction Research Network observational cohort study enrolled adult women with bothersome UU and/or UU incontinence using the lower urinary tract symptoms (LUTS) Tool who were seeking care for LUTS. Treatments for UU and/or urgency incontinence were ordered from least to most invasive. Ordinal logistic and Cox proportional hazard regression models were fit to predict the most invasive level of treatment during follow‐up and overactive bladder (OAB) medication discontinuation, respectively. Binary logistic regression was performed to predict sling treatment during the study follow‐up. Clinical tools were then created using the models listed above to predict treatment pattern over 12 months.ResultsAmong 349 women, 281 reported UU incontinence, and 68 reported UU at baseline. The highest level of treatment during the study was as follows: 20% no treatment, 24% behavioral treatments, 23% physical therapy, 26% OAB medication, 1% percutaneous tibial nerve stimulation, 3% onabotulinumtoxin A, and 3% sacral neuromodulation. Slings were placed in 10% (n = 36) of participants before baseline and in 11% (n = 40) during study follow‐up. Baseline factors associated with predicting the most invasive level of treatment included baseline level of treatment, hypertension, UU incontinence severity, stress urinary incontinence (SUI) severity, and anticholinergic burden score. Less severe baseline depression and less severe UU incontinence were associated with OAB medication discontinuation. UU and SUI severity were associated with sling placement during the study period. Three tools are available to predict: (1) highest level of treatment; (2) OAB medication discontinuation; and (3) sling placement.ConclusionsOAB treatment prediction tools developed in this study can help providers individualize treatment plans and identify not only patients at risk for treatment discontinuation but also patients who may not be escalated to potentially beneficial OAB treatments, with the goal to improve clinical outcomes for patients suffering from this chronic and often debilitating condition.
Management of pharmacovigilance during the COVID‐19 pandemic crisis by the safety department of an academic sponsor: Lessons learnt and challenges from the EU DisCoVeRy clinical trial
Authors: Mercier Noémie , Belhadi Drifa , DeChanet Aline , Delmas Christelle , Saillard Juliette , Dumousseaux Marina , Le Mestre Soizic , Fougerou‐Leurent Claire , Ferrane Assia , Burdet Charles , Espérou Hélène , Ader Florence , Hites Maya , Peiffer‐Smadja Nathan , Poissy Julien , Andrejak Claire , Paiva José Artur , Tacconelli Evelina , Staub Thérèse , Greil Richard , Costagliola Dominique , Mentre France , Yazdanpanah Yazdan , Diallo Alpha ,   the DisCoVeRy Safety Working group
Published: June 2023

AbstractThe current COVID‐19 pandemic was an exceptional health situation, including for drug use. As there was no known effective drug for COVID‐19 at the beginning of the pandemic, different drug candidates were proposed. In this article, we present the challenges for an academic Safety Department to manage the global safety of a European trial during the pandemic. The National Institute for Health and Medical Research (Inserm) conducted a European multicenter, open‐label, randomized, controlled trial involving three repurposed and one‐in development drugs (lopinavir/ritonavir, IFN‐β1a, hydroxychloroquine, and remdesivir) in adults hospitalized with COVID‐19. From 25 March 2020 to 29 May 2020, the Inserm Safety Department had to manage 585 Serious Adverse Events (SAEs) initial notification and 396 follow‐up reports. The Inserm Safety Department's staff was mobilized to manage these SAEs and to report Expedited safety reports to the competent authorities within the legal timeframes. More than 500 queries were sent to the investigators due to a lack of or incoherent information on SAE forms. At the same time, the investigators were overwhelmed by the management of patients suffering from COVID‐19 infection. These particular conditions of missing data and lack of accurate description of adverse events made evaluation of the SAEs very difficult, particularly the assessment of the causal role of each investigational medicinal product. In parallel, working difficulties were accentuated by the national lockdown, frequent IT tool dysfunctions, delayed implementation of monitoring and the absence of automatic alerts for SAE form modification. Although COVID‐19 is a confounding factor per se, the delay in and quality of SAE form completion and the real‐time medical analysis by the Inserm Safety Department were major issues in the quick identification of potential safety signals. To conduct a high‐quality clinical trial and ensure patient safety, all stakeholders must take their roles and responsibilities.
On the non‐recursive dynamic control for uncertain nonlinear systems
Authors: Wang Peng , Liang Xiaoling , Yong Kenan , Chen Mou 
Published: June 2023

SummaryThis paper presents a non‐recursive tracking control for systems under the presence of mismatched disturbances. Firstly, through integrating a series of extended state observers (ESO) for the dynamics at each order, the uncertainties and their corresponding order derivatives can be estimated accurately within finite time. Then through utilizing all the estimations of ESOs and taking advantages of the homogeneous system theory, a non‐recursive control works to guarantee the finite‐time stability in a concise manner. This kind of non‐recursive design framework is conducive to cost‐saving and promoting practical implementations, detached from the determination of a series of virtual controllers. Additionally, to employ the time‐varying scaling gain for better tracking performance, two kinds of forms, namely the adaptive tuning and implicit‐Lyapunov‐function (ILF)‐based tuning laws, have been proposed to speed up the convergence rate and increase the tracking accuracy. Finally, numerical example results are presented to illustrate the performance of the proposed control scheme.
In Vivo and Network Pharmacological Studies of Natural Bear Bile Powder Against Hyperlipidemia
Authors: Wang Xi , Qin Xiaoyan , Tian Maoying , Dong Zhaowei , Wang Chao , Guo Guangpeng , Huang Qinwan , Wang Jin 
Published: June 2023

AbstractNatural bear bile powder (NBBP), a traditional Chinese medicine, has been clinically used to treat liver dysfunction, cardiovascular and cerebrovascular diseases. Recently it has been proved that NBBP has a good effect on regulating lipid disorders. However, the active ingredients and the anti‐hyperlipidemic effects are unclear. The high‐fat diet (HFD) induced hyperlipidemic model rats were treated with NBBP for 4 weeks and were examined for, lipid profile, liver function parameters, hepatic antioxidant status and histopathology of liver, epididymal adipose tissues. The NBBP treatment effectively improved serum lipid levels and normalized antioxidant status. A total of 16 constituents of NBBP were charactered via UHPLC‐Q‐TOF‐HRMS. We screened eight potentially active compounds and corresponded to 75 anti‐hyperlipidemic target proteins. PPI analysis showed that ALB, TNF, EGFE, PPARG, and PPARA are core proteins. Pathway enrichment analysis showed that NBBP might treat hyperlipidemia (HLP) by regulating a series of signaling pathways involving immune system, inflammatory response, and metabolism. Molecular docking revealed that gene had high affinities to NBBP compounds. In conclusion, UHPLC‐Q‐TOF‐HRMS analysis, network pharmacology, and in vivo experiments in this study provided essential references for revealing the potential mechanism of NBBP in the prevention and treatment of HLP.
Osmotically Delaminated Silicate Nanosheet‐Coated NCM for Ultra‐Stable Li+ Storage and Chemical Stability Toward Long‐Term Air Exposure
Authors: Stevenson Max , Weiß Sebastian , Cha Gihoon , Schamel Maximilian , Jahn Leonard , Friedrich Daniel , Danzer Michael A. , Cheong Jun Young , Breu Josef 
Published: June 2023

AbstractTo ensure the safety and performance of lithium‐ion batteries (LIBs), a rational design and optimization of suitable cathode materials are crucial. Lithium nickel cobalt manganese oxides (NCM) represent one of the most popular cathode materials for commercial LIBs. However, they are limited by several critical issues, such as transition metal dissolution, formation of an unstable cathode‐electrolyte interphase (CEI) layer, chemical instability upon air exposure, and mechanical instability. In this work, coating fabricated by self‐assembly of osmotically delaminated sodium fluorohectorite (Hec) nanosheets onto NCM (Hec‐NCM) in a simple and technically benign aqueous wet‐coating process is reported first. Complete wrapping of NCM by high aspect ratio (>10 000) nanosheets is enabled through an electrostatic attraction between Hec nanosheets and NCM as well as by the superior mechanical flexibility of Hec nanosheets. The coating significantly suppresses mechanical degradation while forming a multi‐functional CEI layer. Consequently, Hec‐NCM delivers outstanding capacity retention for 300 cycles. Furthermore, due to the exceptional gas barrier properties of the few‐layer Hec‐coating, the electrochemical performance of Hec‐NCM is maintained even after 6 months of exposure to the ambient atmosphere. These findings suggest a new direction of significantly improving the long‐term stability and activity of cathode materials by creating an artificial CEI layer.
Ceo2/Cus Nanoplates Electroreduce Co2 to Ethanol with Stabilized Cu+ Species
Authors: Yang Zi , Ji Deguang , Li Zhi , He Zidong , Hu Yang , Yin Jie , Hou Yichao , Xi Pinxian , Yan Chun‐Hua 
Published: June 2023

AbstractCopper‐based electrocatalysts effectively produce multicarbon (C2+) compounds during the electrochemical CO2 reduction (CO2RR). However, big challenges still remain because of the chemically unstable active sites. Here, cerium is used as a self‐sacrificing agent to stabilize the Cu+ of CuS, due to the facile Ce3+/Ce4+ redox. CeO2‐modified CuS nanoplates achieve high ethanol selectivity, with FE up to 54% and FEC2+ ≈ 75% in a flow cell. Moreover, in situ Raman spectroscopy and in situ Fourier‐transform infrared spectroscopy indicate that the stable Cu+ species promote CC coupling step under CO2RR. Density functional theory calculations further reveal that the stronger *CO adsorption and lower CC coupling energy, which is conducive to the selective generation of ethanol products. This work provides a facile strategy to convert CO2 into ethanol by retaining Cu+ species.
Interfacial Chemistry Effects in the Electrochemical Performance of Silicon Electrodes under Lithium‐Ion Battery Conditions
Authors: Xu Xiangdong , Martín‐Yerga Daniel , Grant Nicholas E. , West Geoff , Pain Sophie L. , Kang Minkyung , Walker Marc , Murphy John D. , Unwin Patrick R. 
Published: June 2023

AbstractUnderstanding the solid electrolyte interphase (SEI) formation and (de)lithiation phenomena at silicon (Si) electrodes is key to improving the performance and lifetime of Si‐based lithium‐ion batteries. However, these processes remain somewhat elusive, and, in particular, the role of Si surface termination merits further consideration. Here, scanning electrochemical cell microscopy (SECCM) is used in a glovebox, followed by secondary ion mass spectrometry (SIMS) at identical locations to study the local electrochemical behavior and associated SEI formation, comparing Si (100) with a native oxide layer (SiOx/Si) and etched with hydrofluoric acid (HF‐Si). HF‐Si shows greater spatial electrochemical heterogeneity and inferior lithiation reversibility than SiOx/Si. This is attributed to a weakly passivating SEI and irreversible lithium trapping at the Si surface. Combinatorial screening of charge/discharge cycling by SECCM with co‐located SIMS reveals SEI chemistry as a function of depth. While the SEI thickness is relatively independent of the cycle number, the chemistry – particularly in the intermediate layers – depends on the number of cycles, revealing the SEI to be dynamic during cycling. This work serves as a foundation for the use of correlative SECCM/SIMS as a powerful approach to gain fundamental insights on complex battery processes at the nano‐ and microscales.
Exploring the Magnetic Properties of Individual Barcode Nanowires using Wide‐Field Diamond Microscopy
Authors: Yoon Jungbae , Moon Jun Hwan , Chung Jugyeong , Kim Yu Jin , Kim Kihwan , Kang Hee Seong , Jeon Yoo Sang , Oh Eunsoo , Lee Sun Hwa , Han Kihoon , Lee Dongmin , Lee Chul‐Ho , Kim Young Keun , Lee Donghun 
Published: June 2023

AbstractA barcode magnetic nanowire typically comprises a multilayer magnetic structure in a single body with more than one segment type. Interestingly, due to selective functionalization and novel interactions between the layers, it has attracted significant attention, particularly in bioengineering. However, analyzing the magnetic properties at the individual nanowire level remains challenging. Herein, the characterization of a single magnetic nanowire is investigated at room temperature under ambient conditions based on magnetic images obtained via wide‐field quantum microscopy with nitrogen‐vacancy centers in diamond. Consequently, critical magnetic properties of a single nanowire can be extracted, such as saturation magnetization and coercivity, by comparing the experimental result with that of micromagnetic simulation. This study opens up the possibility for a versatile in situ characterization method suited to individual magnetic nanowires.
Typification of the scientific names of the common almond Prunus dulcis and its wild relative P. webbii (Rosaceae, Prunoideae)
Authors: Ferrer‐Gallego P. Pablo , Wajer Jacek , Benítez Guillermo 
Published: June 2023

AbstractThe typifications of the scientific names of the common almond Amygdalus dulcis (≡ Prunus dulcis; Rosaceae, Prunoideae) and the Mediterranean almond tree A. webbii (≡ P. webbii), a wild relative of the common almond, are discussed. Amygdalus dulcis is neotypified on a specimen at VAL recently collected from a living tree of the variety of almond most similar to the original description. Amygdalus webbii is lectotypified on a specimen preserved at P collected by Pierre Martin Rémi Aucher‐Éloy.
Ultrasound‐guided saphenous and sciatic nerve block with ropivacaine in an adult goat undergoing trochlear sulcoplasty for lateral patellar luxation
Authors: Herrera‐Linares Manuel E. , Bolt David M. , Meeson Richard , Sanchis‐Mora Sandra 
Published: June 2023

AbstractA 75 kg, 4‐year‐old, male, neutered, Saanen‐cross, pet‐owned, adult goat presented for left trochlear sulcoplasty for treatment of lateral patellar luxation. Premedication consisted of intravenous butorphanol (0.2 mg/kg), and midazolam (0.5 mg/kg, intravenous), followed by ketamine (2 mg/kg, intravenous) and propofol (2 mg/kg, intravenous) for induction of anaesthesia. Anaesthesia was maintained using isoflurane in oxygen (100%) and mechanical ventilation was started. An ultrasound‐guided saphenous and sciatic nerve block with 0.1 mL/kg of ropivacaine 0.75% and 0.25%, respectively, was performed. Anaesthesia was uneventful, except for a transient period of hypotension and a nociceptive reaction during skin suture. Recovery was uneventful. No motor block was observed using this combination of ropivacaine concentrations. Buprenorphine (0.01 mg/kg, intravenous) was initiated (twice daily first day; once daily second and third day) 6.5 hours after the nerve block due to discomfort. Meloxicam (0.5 mg/kg, intravenous) was administered once daily for 5 days, after which the patient was fully ambulatory.
Activity-dependent regulation of the BAX/BCL-2 pathway protects cortical neurons from apoptotic death during early development
Authors: Schroer Jonas , Warm Davide , De Rosa Federico , Luhmann Heiko J. , Sinning Anne 
Published: June 2023

AbstractDuring early brain development, homeostatic removal of cortical neurons is crucial and requires multiple control mechanisms. We investigated in the cerebral cortex of mice whether the BAX/BCL-2 pathway, an important regulator of apoptosis, is part of this machinery and how electrical activity might serve as a set point of regulation. Activity is known to be a pro-survival factor; however, how this effect is translated into enhanced survival chances on a neuronal level is not fully understood. In this study, we show that caspase activity is highest at the neonatal stage, while developmental cell death peaks at the end of the first postnatal week. During the first postnatal week, upregulation of BAX is accompanied by downregulation of BCL-2 protein, resulting in a high BAX/BCL-2 ratio when neuronal death rates are high. In cultured neurons, pharmacological blockade of activity leads to an acute upregulation of Bax, while elevated activity results in a lasting increase of BCL-2 expression. Spontaneously active neurons not only exhibit lower Bax levels than inactive neurons but also show almost exclusively BCL-2 expression. Disinhibition of network activity prevents the death of neurons overexpressing activated CASP3. This neuroprotective effect is not the result of reduced caspase activity but is associated with a downregulation of the BAX/BCL-2 ratio. Notably, increasing neuronal activity has a similar, non-additive effect as the blockade of BAX. Conclusively, high electrical activity modulates BAX/BCL-2 expression and leads to higher tolerance to CASP3 activity, increases survival, and presumably promotes non-apoptotic CASP3 functions in developing neurons.
Systematic lateral retinacular release does not reduce anterior knee pain after total knee arthroplasty with patellar resurfacing
Authors: Goicoechea Nerea , Hinarejos Pedro , Gasol Berta , Torres‐Claramunt Raul , Sánchez‐Soler Juan , Perelli Simone , Monllau Joan Carles 
Published: June 2023

AbstractPurposeThe aim of this study was to assess the effect of systematic lateral retinacular release (LRR) on anterior knee pain (AKP), as well as its impact on the functional and radiological outcomes after total knee arthroplasty (TKA) with patellar resurfacing.MethodsA prospective randomized study was designed. It included patients scheduled for a TKA procedure with patellar resurfacing, who were recruited and randomized into either the LRR group or the non‐release group. 198 patients were included in the final analysis. The pressure pain threshold (PPT) assessed by pressure algometry (PA), the visual analogue scale (VAS), Feller's patellar score, the Knee Society Score (KSS), patellar height, and patellar tilt were recorded both preoperatively and at the 1‐year follow‐up. The Mann–Whitney U test was performed to determine comparisons between both groups as well as to determine differences’ intragroup.ResultsRelative to the clinical variables and scores, no difference was detected between the two groups at the 1‐year follow‐up (p = n.s.). However, there was a slight difference in patellar tilt (0.1º vs. 1.4º, p = 0.044), with higher tilt values in the non‐release group. There was no difference in terms of improvement in the clinical and radiological scores and variables recorded between the two groups (p = n.s.).ConclusionLRR in primary TKA with patellar resurfacing does not show an improvement in AKP and functional outcomes over patellar resurfacing without release.Level of evidenceI.