bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between signs of sleep bruxism and insomnia: A polysomnographic study
Authors: Kuang Boyuan , Aarab Ghizlane , Wei Yishul , Blanken Tessa F. , Lobbezoo Frank , Someren Eus J. W. Van , Ramautar Jennifer R. , Wassing Rick 
Published: January 2023

SummarySleep bruxism (SB) is a repetitive jaw‐muscle activity characterised by clenching or grinding of the teeth and/or by bracing or thrusting of the mandible. Sleep bruxism has been linked with insomnia symptoms. Moreover, it has been suggested that there is a positive association between distress and the occurrence of sleep bruxism. However, the occurrence of sleep bruxism and its association with distress have not been studied in patients with insomnia. Therefore, we hypothesised that: (1) the occurrence of sleep bruxism is higher in patients with insomnia than in healthy controls; and (2) the occurrence of sleep bruxism in insomnia patients with moderate to high distress (IMHD) is higher than that in insomnia patients with slight distress (ISD). A total of 44 controls (34 females, 10 males, mean ± SD age = 46.8 ± 14.4 years) and 42 participants with insomnia (35 females, 7 males, mean ± SD age = 51.3 ± 12.1 years) were enrolled in this study. Among 42 participants with insomnia, 20 participants were subtyped as IMHD, 17 participants as ISD. Another five participants were not subtyped due to insufficient information. Group differences in rhythmic masticatory muscle activity (RMMA), a biomarker of sleep bruxism, were evaluated with Mann–Whitney U tests. The medians and interquartile ranges of the RMMA indices were 0.8|1.8|3.3 in controls, 1.1|1.6|2.3 in IMHD and 1.2|1.9|2.9 in ISD. There was no significant difference in the RMMA index, neither between participants with insomnia and controls (P = 0.514) nor between IMHD versus ISD (P = 0.270). The occurrence of RMMA indicators of possible sleep bruxism is not significantly different between individuals with insomnia and controls, nor between IMHD versus ISD.
Genetic responses in sexual diploid and unisexual triploid goldfish (Carassius auratus) introduced into a high‐altitude environment
Authors: Feng Xiu , Liu Shenglin , Sui Xiaoyun , Chen Yifeng , Zhu Ren , Jia Yintao , Tong Jingou , Yu Xiaomu , Liu Chunlong , Hansen Michael M. 
Published: January 2023

AbstractAnthropogenic biological invasions represent major concerns but enable us to investigate rapid evolutionary changes and adaptation to novel environments. The goldfishCarassius auratuswith sexual diploids and unisexual triploids coexisting in natural waters is one of the most widespread invasive fishes in Tibet, providing an ideal model to study evolutionary processes during invasion in different reproductive forms from the same vertebrate. Here, using whole‐genome resequencing data of 151C. auratusindividuals from invasive and native ranges, we found different patterns of genomic responses between diploid and triploid populations during their invasion of Tibet. For diploids, although invasive individuals derived from two different genetically distinct sources had a relative higher diversity (π) at the population level, their individual genetic diversity (genome‐wide observed heterozygosity) was significantly lower (21.4%) than that of source individuals. Population structure analysis revealed that the invasive individuals formed a specific genetic cluster distinct from the source populations. Runs of homozygosity analysis showed low inbreeding only in invasive individuals, and only the invasive population experienced a recent decline in effective population size reflecting founder events. For triploids, however, invasive populations showed no loss of individual genetic diversity and no genetic differentiation relative to source populations. Regions of putative selective sweeps between invasive and source populations of diploids mainly involved genes associated with mannosidase activity and embryo development. Our results suggest that invasive diploids deriving from distinct sources still lost individual genetic diversity resulting from recent inbreeding and founder events and selective sweeps, and invasive triploids experienced no change in genetic diversity owing to their reproduction mode of gynogenesis that precludes inbreeding and founder effects and may make them more powerful invaders.
Taxation and citizen choice: The effect of a county charter on property taxes
Authors: Larson Sarah E. , McDonald Bruce D. 
Published: January 2023

AbstractAs saliency of the tax burden increases, the preference for a lower burden increases, but most counties are restricted by the state from adopting new taxes or changing the existing rates. Some states allow counties to adopt a charter, freeing them from state control. Using a panel of Florida counties from 1980 to 2017, we explore whether citizens act to reduce their property tax once a charter is passed. Citizens act against their preferences not by lowering burden but rather by increasing it in the case of debt service, suggesting citizens are maximizing their optimal tax burden in exchange for services.
“Rule‐Following I: The Basic Issues”
Authors: Reiland Indrek 
Published: January 2023

Abstract‘Rule‐following’ is a name for a cluster of phenomena where we seem both guided and “normatively” constrained by something general in performing particular actions. Understanding the phenomenon is important because of its connection to meaning, representation, and content. This article gives an overview of the philosophical discussion of rule‐following. Part I of this two‐part contribution is devoted to the basic issues from Wittgenstein to Kripkenstein's skeptical paradox. Part II will be about recent answers to the skeptical paradox and Boghossian's and Wright's new puzzles.
The Violence of the Benevolent Ruler: Classical Confucianism and Punitive Expedition
Authors: Kim Sungmoon 
Published: January 2023

AbstractIn the past two decades, scholars in China and beyond have vigorously demonstrated that the just war discourse is integral to classical Confucianism and that the classical Confucian idea of “punitive expedition” can be best understood in terms of humanitarian intervention. The sceptics, however, claim that in describing the ancient sage‐king's bloodless punitive expeditions, what classical Confucians really had in mind was not so much to endorse morally justified forms of aggressive war but to highlight the paramount importance of the ruler's moral self‐cultivation and benevolent government. This paper examines closely the disagreement between the two positions and offers a more historically grounded justification for the just war interpretation of classical Confucianism. It pays special attention to the importance of ritual order in classical Confucian political theory and discusses how the Warring States political circumstances led thinkers such as Mencius and Xunzi to shift their attention from ritual order to the well‐being of the people.
Integrated versus segmented markets: Implications for export pricing and welfare
Authors: Becker Raphael , Nigai Sergey , Seidel Tobias 
Published: January 2023

AbstractThis paper challenges the common assumption of perfect market segmentation in models based on monopolistic competition. We develop a tractable approach to analyze export entry and pricing decisions of firms and show that the trade costs triangle condition (absence of potential re‐exporting arbitrage) imposes constraints on firm‐level export prices, which have first‐order implications for trade and welfare. We provide empirical evidence that the triangle condition is violated in the data and quantify the importance of these violations in a general equilibrium setting.
Influence of sediment composition on morphology and internal structure of mixed siliciclastic–bioclastic coastal barriers: Contribution of flume experiments
Authors: Rieux Alissia , Weill Pierre , Mouazé Dominique , Tessier Bernadette 
Published: January 2023

ABSTRACTCoastal barriers are dynamic systems, the morphology and architecture of which are controlled by local hydrodynamics, sea‐level fluctuations at different timescales, geological heritage and sediment composition. Coastal barriers may be composed of siliciclastic sediments, bioclastic sediments, or a mixture of both. Mixed siliciclastic–bioclastic sediments (as common as ‘pure’ sediments) are still little represented in the literature. Changes in sediment composition could affect sedimentary processes which are involved in the construction and stability of coastal barriers due to a different hydrodynamic behaviour between bioclastic and siliciclastic particles. In this study, wave‐flume experiments were used to investigate the role of sediment compositional mixing on the morphology and architecture of coastal barriers. Three different siliciclastic/bioclastic mixtures were exposed to regular wave forcing, together with mean water level fluctuations to create regressive and transgressive depositional units. Compositional mixtures responded similarly in first‐order to mean water‐level fluctuations, with the formation of a bar at low water level. Its subsequent on‐shore migration and reworking as berm deposits during rising water level stages, and with the formation of washover deposits during high water level stages. In detail, the increasing content of bioclastic sediment increased the beachface slope and reduced the length of washover deposits. The faster aggradation of washover sheets with bioclastic‐rich mixtures accelerated the barrier recovery after a submersion and breaching event. A strong segregation between the siliciclastic and the bioclastic grains was observed in the different depositional units, which is attributed both to the coarse size (grain‐size control) and to the flat‐shape (compositional control) of the bioclastic particles.
Unwanted Family Planning: Prevalence Estimates for 56 Countries
Authors: Canning David , Karra Mahesh 
Published: January 2023

AbstractWhile there is a large literature on the prevalence of unmet need for family planning, there is no matching quantitative evidence on the prevalence of unwanted family planning; all contraceptive use is assumed to represent a “met need.” This lack of evidence raises concerns that some observed contraceptive use may be undesired and coercive. We provide estimates of unwanted family planning using Demographic and Health Survey data collected from 1,546,987 women in 56 low‐ and middle‐income countries between 2011 and 2019. We estimate the prevalence of unwanted family planning, defined as the proportion of women who report wanting a child in the next nine months but who are using contraception. We find that 12.2 percent of women have an unmet need for family planning, while 2.1 percent have unwanted family planning, with estimated prevalence rates ranging from 0.4 percent in Gambia to 7.1 percent in Jordan. About half of unwanted family planning use can be attributed to condoms, withdrawal, and abstinence. Estimating the prevalence of unwanted family planning is difficult given current data collection efforts, which are not designed for this purpose. We recommend that future surveys probe the reasons for the use of family planning.
Traumatic pulmonary pseudocysts in nine dogs and two cats
Authors: González Montaño Hilario , Agthe Petra , Cantatore Matteo 
Published: January 2023

AbstractObjectiveTo describe the clinical presentation, imaging findings, treatment, and outcome in dogs and cats with traumatic pulmonary pseudocysts (TPP).Study designRetrospective observational study.AnimalsNine client‐owned dogs and two cats.MethodsThe hospital database of Anderson Moores Veterinary Specialists was reviewed for cases with a diagnosis of TPP based on computed tomography (CT). Clinical presentation, additional injuries, treatment, and outcome were recorded.ResultsEleven patients with TPP were identified. The ratio of TPP detected by radiographs when compared to CT was 7:11 (64%). Seven cases were managed conservatively, and three underwent lung lobectomy. One cat was euthanized due to the severity of concomitant injuries. The decision to perform thoracic surgery was due to refractory pneumothorax (2) or very large TPP (1). Ten patients survived to discharge. No patients died as a result of the TPP.ConclusionRadiographic lesions were identified in about two‐thirds of cases diagnosed by CT. TPPs were not fatal in our population but were commonly associated with severe concomitant injuries. Conservative treatment led to the resolution of smaller TPPs.Clinical significanceConservative management of TPP is appropriate in most cases, although selected cases may benefit from surgical treatment.
Heat Transfer and Pressure Loss of Additively Manufactured Internal Cooling Channels With Various Shapes
Authors: Wildgoose Alexander J. , Thole Karen A. 
Published: January 2023

AbstractAdditive manufacturing (AM) provides the ability to fabricate highly customized internal cooling passages that are relevant to gas turbine components. This experimental study examines the pressure loss and heat transfer performance of a range of fundamental channel shapes that were produced using direct metal laser sintering. Circular, hexagonal, pentagonal, elliptical, diamond, square, rectangular, trapezoidal, and triangular channel cross sections were investigated. To maintain the same convective surface area between shapes, the wetted perimeters of the channel cross sections were kept constant. Parallel computational fluid dynamic simulations were performed to understand the relationships in cooling performance between several channel shapes. Several characteristic length scales were evaluated to scale the pressure loss and heat transfer measurements. Among the channel shapes investigated, the diamond channel showed the lowest Nusselt number and friction factor. The pentagon exhibited a similar Nusselt number as the circular channel despite having a lower friction factor. There was no difference in scaling the friction factor or Nusselt number results of the different channel shapes between using the square root of cross-sectional area compared to hydraulic diameter as the characteristic length scale
Thermal history modeling techniques and interpretation strategies: Applications using QTQt
Authors: Abbey Alyssa L. , Wildman Mark , Stevens Goddard Andrea L. , Murray Kendra E. 
Published: January 2023

AbstractAdvances in low-temperature thermochronology have made it applicable to a plethora of geoscience investigations. The development of modeling programs (e.g., QTQt and HeFTy) that extract thermal histories from thermochronologic data has facilitated growth of this field. However, the increasingly wide range of scientists who apply these tools requires an accessible entry point to thermal history modeling and how these models develop our understanding of complex geological processes. This contribution offers a discussion of modeling strategies, using QTQt, including making decisions about model design, data input, kinetic parameters, and other factors that may influence the model output. We present a suite of synthetic data sets derived from known thermal histories with accompanying tutorial exercises in the Supplemental Material1. These data sets illustrate the opportunities and limitations of thermal history modeling. Examining these synthetic data helps to develop intuition about which thermochronometric data are most sensitive to different thermal events and to what extent user decisions on data handling and model setup can control the recovery of the true solution. We also use real data to demonstrate the importance of incorporating sensitivity testing into thermal history modeling and suggest several best practices for exploring model sensitivity to factors including, but not limited to, the model design or inversion algorithm, geologic constraints, data trends, the spatial relationship between samples, or the choice of kinetics model. Finally, we provide a detailed and explicit workflow and an applied example for a method of interrogating vague model results or low observation-prediction fits that we call the “Path Structure Approach.” Our explicit examination of thermal history modeling practices is designed to guide modelers to identify the factors controlling model results and demonstrate reproducible approaches for the interpretation of thermal histories.
Pancreaticobiliary versus head and neck presentation of immunoglobulin G4-related disease: different sides of the same coin?
Authors: Awadelkarim Bidour , Vila Josephine , Nayar Manu K , Leeds John S , Griffiths Bridget , Oppong Kofi W 
Published: January 2023

Background and study aimImmunoglobulin G4-related disease (IgG4-RD) is a rare immune mediated fibroinflammatory condition. Pancreaticobiliary (PB) and head and neck (HN) are two of the most commonly involved anatomical sites. It has been postulated that PB IgG4-RD and HN IgG4-RD have distinct clinical phenotypes. Whether the optimum treatment regimen or response to therapy differs between them is unknown. We aimed to assess differences between PB and HN IgG4-RD in a cohort of IgG4 disease managed by an IgG4-RD multispecialty team.MethodsWe performed a retrospective study of a prospectively maintained multidisciplinary IgG4-RD database to identify patients diagnosed with PB and HN IgG4-RD (based on initial presentation) between 2005 and 2019. The electronic patient records were reviewed. Use of immunosuppressive agents and clinical course was analysed.Results60 patients with PB IgG4-RD and 14 with HN IgG4-RD were included in the study. PB IgG4-RD was associated with older age at diagnosis 64 versus 51 years (p<0.001), higher serum IgG4 level as a multiple of upper limit of normal median (IQR) 2 (1–3.75) vs 1 (1–2), (p=0.04) and greater proportion with more than one organ involved 68% vs 33% (p=0.03). HN IgG4-RD was more likely to receive second-line therapy 71% versus 36% (p=0.03). Persistent elevation of serum IgG4 after therapy was more common in PB IgG4-RD 84% versus 43% (p=0.03).ConclusionThese findings support the contention that PB IgG4-RD and HN IgG4-RD have different clinical profiles and represent distinct subtypes of IgG4-RD.
Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study
Authors: Garcia-Rio Francisco , Miravitlles Marc , Soriano Joan B , Cosío Borja G , Soler-Cataluña Juan José , Casanova Ciro , de Lucas Pilar , Alfageme Inmaculada , Rodríguez González-Moro José Miguel , Sánchez Herrero María Guadalupe , Ancochea Julio 
Published: January 2023

BackgroundPopulation distribution of reduced diffusing capacity of the lungs for carbon monoxide (DLCO) in smokers and main consequences are not properly recognised. The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications.MethodsA sample of 405 subjects aged 40 years or older with postbronchodilator forced expiratory volume in 1 s/forced vital capacity (FVC) >0.70 was obtained from a random population-based sample of 9092 subjects evaluated in the EPISCAN II study. Baseline evaluation included clinical questionnaires, exhaled carbon monoxide (CO) measurement, spirometry, DLCO determination, 6 min walk test, routine blood analysis and low-dose CT scan with evaluation of lung density and airway wall thickness.ResultsIn never, former and current smokers, prevalence of reduced DLCO was 6.7%, 14.4% and 26.7%, respectively. Current and former smokers with reduced DLCO without airflow limitation were younger than the subjects with normal DLCO, and they had greater levels of dyspnoea and exhaled CO, greater pulmonary artery diameter and lower spirometric parameters, 6 min walk distance, daily physical activity and plasma albumin levels (all p<0.05), with no significant differences in other chronic respiratory symptoms or CT findings. FVC and exhaled CO were identified as independent risk factors for low DLCO.ConclusionReduced DLCO is a frequent disorder among smokers without airflow limitation, associated with decreased exercise capacity and with CT findings suggesting that it may be a marker of smoking-induced early vascular damage.Trial registration numberNCT03028207.
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade
Authors: Conche Claire , Finkelmeier Fabian , Pešić Marina , Nicolas Adele M , Böttger Tim W , Kennel Kilian B , Denk Dominic , Ceteci Fatih , Mohs Kathleen , Engel Esther , Canli Özge , Dabiri Yasamin , Peiffer Kai-Henrik , Zeuzem Stefan , Salinas Gabriela , Longerich Thomas , Yang Huan , Greten Florian R 
Published: January 2023

ObjectiveInvestigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment.DesignGlutathione peroxidase 4 (GPx4), which is considered the master regulator of ferroptosis, was genetically altered in murine models for hepatocellular carcinoma (HCC) and colorectal cancer (CRC) to analyse the effect of ferroptosis on tumour cells and the immune tumour microenvironment. The findings served as foundation for the identification of additional targets for combine therapy with ferroptotic inducer in the treatment of HCC and liver metastasis.ResultsSurprisingly, hepatocyte-restricted GPx4 loss does not suppress hepatocellular tumourigenesis. Instead, GPx4-associated ferroptotic hepatocyte death causes a tumour suppressive immune response characterised by a CXCL10-dependent infiltration of cytotoxic CD8+T cells that is counterbalanced by PD-L1 upregulation on tumour cells as well as by a marked HMGB1-mediated myeloid derived suppressor cell (MDSC) infiltration. Blocking PD-1 or HMGB1 unleashes T cell activation and prolongs survival of mice withGpx4-deficient liver tumours. A triple combination of the ferroptosis inducing natural compound withaferin A, the CXCR2 inhibitor SB225002 and α-PD-1 greatly improves survival of wild-type mice with liver tumours. In contrast, the same combination does not affect tumour growth of subcutaneously grown CRC organoids, while it decreases their metastatic growth in liver.ConclusionOur data highlight a context-specific ferroptosis-induced immune response that could be therapeutically exploited for the treatment of primary liver tumours and liver metastases.
Short-term effect of colorectal cancer on income: analysis of an Italian cohort
Authors: Farina Elena , Rosso Marco , Dansero Lucia , Ippoliti Roberto , Numico Gianmauro , Macciotta Alessandra , Bena Antonella , Ricceri Fulvio 
Published: January 2023

IntroductionThe ability to return to work after a cancer diagnosis is a key aspect of cancer survivorship and quality of life. Studies have reported a significant risk of income loss for cancer survivors; however, there is limited evidence of the Italian context.MethodsThe Work Histories Italian Panel (WHIP)-Salute database was used to select a cohort of incident cases of colorectal cancer (CRC) among workers in the private sector, based on hospital discharges. A propensity score matching was used to find a balanced control group for several confounders. Ordinary least square and logistic regressions were used to estimate the effect of a CRC diagnosis on annual income and the probability of switching from a full-time contract to a part-time one considering 3 years after the diagnosis.ResultsOverall, we identified 925 CRC incident cases from 2006 until 2012. Our results confirm a statistically significant reduction in survivors’ income compared with controls. This reduction was greater in the first year and then tend to decrease, with an average income loss over 3 years of about €12 000. Stratified analyses by sex and position confirmed the overall trend while indicating a strong effect modification. Regarding the switching from full-time to part-time employment, the results were never significant.ConclusionIncome loss does not seem to be related to an increase in part-time contracts, but rather to survivors’ reduced work capacity following the invasive treatments. Further research is needed to investigate the complex dynamics behind this association.