bluuebunny/crossref_metadata_2025_split huggingface dataset:
Firesafe Lumber
Authors: Storm Raymond W. 
Published: April 2023

Abstract
Methods are given of rendering wood non-inflammable by impregnation with various chemicals in aqueous solutions, together with the subsequent drying of the treated lumber and the important characteristics of the products thus produced. The author has sought to emphasize mainly the commercial or practical side of manufacture and use rather than the purely technical or theoretical aspects of “Firesafe” wood.
End-Matching, Edge-Jointed and Surface-Laminated Wood Parts for Auto-Body Building
Authors: White G. G. 
Published: April 2023

Abstract
Advantages and savings from cutting lumber to final dimensions at the point of supply are discussed in this paper. Freight charges on waste and on the moisture removed in kiln drying are saved. In addition a lower grade of lumber can be used, and by cutting to size and shipping in bundles, the cost of handling is reduced and much less storage space is needed. The author describes various manufacturing processes used in the construction of wood frames for automobile bodies. Use of laminated woods has done much to conserve the timber supply because species of woods not previously used can be worked satisfactorily.
Manufacturing Upright- and Grand-Piano Cases
Authors: Lindsey Joseph T. 
Published: April 2023

Abstract
In this paper the author tells of the various manufacturing operations that are necessary to complete piano cases, and describes the system of following work used by the Foster-Armstrong Company. Emphasis is placed on the fact that an efficient planing system is most essential to obtain best results. Operations carried out in the various departments together with the special machine tools used are described.
Insight Into Recompression Brayton Cycle
Authors: Tatli Akif Eren , You Dongchuan , Ghanavati Ashkan , Metghalchi Hameed 
Published: April 2023

AbstractRecompression cycles have the potential to offer high performance when design parameters such as feasibility, performance, and compactness are considered. These cycles have recently gained attention especially in nuclear and concentrating solar power plants because of their high efficiency and environmentally friendly. A study has been done to investigate and learn more about recompression cycles. In this paper, a recompression Brayton cycle has been analyzed by performing parametric studies on the effectiveness of recuperators, pressure ratio, and split ratio as well as other input variables. To understand the relations between these factors and the performances of the cycle, argon was used as a working fluid because of its constant specific heat. The solution to temperatures at each state has been derived analytically, which is presented as a function of independent input variables. Thermal efficiency and exergy efficiency of this cycle have been determined in these analyses. The model indicates following results: entropy generation of recuperators is lower at a minimum split and decreases with increasing effectiveness. When the cycle is optimized for maximum efficiency it does not operate on maximum specific net work. The energy and exergy efficiencies of the cycle increase with increasing pressure ratio reaching a maximum value at the optimum pressure ratio. The effect of split ratio on temperature difference around recuperators shows that energy recovered at low temperature is higher at a minimum split which yields a higher efficiency in the cycle. The performance of the cycle is strongly affected by turbine inlet temperature.
SW-SiStA2: A New-Generation Semi-Wearable Device for Sit-to-Stand Assistance
Authors: Afsar Md Rayhan , Ashiquzzaman Ashiq , Martelli Dario , Shen Xiangrong 
Published: April 2023

Abstract
Mobility impairment is a major problem that affects the quality of life of numerous older adults. With impaired mobility, such individuals usually have significant difficulty in standing up from a seated position, and thus often suffer from the lack of physical activities in their daily life. To address this problem, the authors present a new assistive device, namely, Semi-Wearable Sit-to-Stand Assist Generation-2 (SW-SiStA2), in this paper. Similar to the original (first generation) SW-SiStA, this novel semiwearable device can be easily attached to the user to provide sit-to-stand assistance, and can also be easily detached after reaching the standing posture to facilitate the subsequent ambulation. The new SW-SiStA2 is powered with a remote-release gas spring, which serves the dual purpose of actuation and energy storage (i.e.,, storing the energy accumulated during compression and powering the sit-to-stand assistance through extension). The remote release feature enables a user to easily control the SW-SiStA2 assistance through the locking and unlocking of the gas spring. The SW-SiStA2 was experimentally tested with human participants. Under the device's assistance, the participants were able to stand up much more easily, with significant reduction (up to 28% compared with the unassisted condition) of the muscle efforts in the process.
Principles for increasing equity in WASH research: understanding barriers faced by LMIC WASH researchers
Authors: Lue J'Anna-Mare , Bah Salamata , Grant Kaelah , Lee Justine , Nzekele Leila , Tidwell James B. 
Published: April 2023

IntroductionThere have long been critiques of colonial legacies influencing global health. With growing public awareness of unjust systems in recent years, a new wave of calls for antiracist and decolonisation initiatives has emerged within the sector. This study examined research inequities in the water, sanitation and hygiene (WASH) sector, centring the perspectives of researchers from low-income and middle-income countries (LMICs), to identify barriers faced by WASH researchers in order to support more equitable changes in this subsector of global health.MethodsNineteen semistructured interviews were conducted with researchers of different backgrounds regarding nationality, gender and research experience. Researchers from eight countries were asked about their experiences and direct observations of discrimination across various stages of the research process. Five interviews were conducted with key WASH research funders to assess perceptions of obstacles faced by LMIC researchers, successes achieved and challenges faced by these organisations when working towards more equitable research processes within the WASH sector.ResultsThe results were analysed using an emergent framework that categorised experiences based on power differentials and abuse of power; structural barriers due to organisational policies; institutional and individual indifference; othering speech, action and practices; and context-specific discrimination. The social-ecological model was combined with this framework to identify the types of actors and the level of co-ordination needed to address these issues. Researchers who worked in both LMICs and high-income countries at different career stages were particularly aware of discrimination. Ensuring pro-equity authorship and funding practices were identified as two significant actions to catalyse change within the sector.ConclusionSector-wide efforts must centre LMIC voices when identifying research questions, conducting research, and in dissemination. Individuals, organisations and the entire WASH sector must examine how they participate in upholding inequitable systems of power to begin to dismantle the system through the intentional yielding of power and resources.
Similarity revisited: shock random walks in the asymmetric simple exclusion process with open boundaries
Authors: Schütz G. M. 
Published: April 2023

AbstractA reverse duality between the asymmetric simple exclusion process (ASEP) with open boundary conditions and a biased random walk of a single particle is proved for a special manifold of boundary parameters of the ASEP. The duality function is given by the configuration probabilities of a family of Bernoulli shock measures with a microscopic shock at site x of the lattice. The boundary conditions of the dual random walk, which can be reflecting or absorbing, depend on the choice of the duality function. As a consequence of this duality, the full time-dependent distribution of the open ASEP starting from a fixed shock measure at x is given for any time $$t>0$$

t
>
0

by a convex combination of shock measures with shock at position y. The coefficients are the transition probabilities P(x, t|y, 0) at time t of the random walk starting at site y. It is also shown that this family of shock measures arises from a similarity transformation of the two-dimensional representation of the matrix algebra for the stationary matrix product measure of the open ASEP. This implies a further duality between random walks with different boundary conditions.
Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With BRCA-Mutated Ovarian Cancer
Authors: Kim Yoo-Na , Shim Yeeun , Seo Jieun , Choi Zisun , Lee Yong Jae , Shin Saeam , Kim Sang Wun , Kim Sunghoon , Choi Jong Rak , Lee Jung-Yun , Lee Seung-Tae 
Published: April 2023

Abstract

Purpose:
Patient-specific molecular alterations leading to PARP inhibitor (PARPi) resistance are relatively unexplored. In this study, we analyzed serially collected circulating tumor DNA (ctDNA) from patients with BRCA1/2 mutations who received PARPis to investigate the resistance mechanisms and their significance in postprogression treatment response and survival.

Experimental Design:
Patients were prospectively enrolled between January 2018 and December 2021 (NCT05458973). Whole-blood samples were obtained before PARPi administration and serially every 3 months until progression. ctDNA was extracted from the samples and sequenced with a 531-gene panel; gene sets for each resistance mechanism were curated.

Results:
Fifty-four patients were included in this analysis. Mutation profiles of genes in pre-PARPi samples indicating a high tumor mutational burden and alterations in genes associated with replication fork stabilization and drug efflux were associated with poor progression-free survival on PARPis. BRCA hypomorphism and reversion were found in 1 and 3 patients, respectively. Among 29 patients with matched samples, mutational heterogeneity increased postprogression on PARPis, showing at least one postspecific mutation in 89.7% of the patients. These mutations indicate non-exclusive acquired resistance mechanisms—homologous recombination repair restoration (28%), replication fork stability (34%), upregulated survival pathway (41%), target loss (10%), and drug efflux (3%). We observed poor progression-free survival with subsequent chemotherapy in patients with homologous recombination repair restoration (P = 0.003) and those with the simultaneous involvement of two or more resistance mechanisms (P = 0.040).

Conclusions:
Analysis of serial ctDNAs highlighted multiple acquired resistance mechanisms, providing valuable insights for improving postprogression treatment and survival.
Global Shift in Alternative Splicing and Therapeutic Susceptibilities in Leukemia Driven by METTL3 Overexpression
Authors: Janin Maxime , Esteller Manel 
Published: April 2023

Summary:Mutations in splicing factors are commonly observed in chronic lymphocytic leukemia (CLL); however, other mechanisms can also contribute to the dysregulation of alternative splicing. One example is the overexpression of the m6A RNA methyltransferase METTL3, that by depositing the epitranscriptomic mark in spliceosome transcripts leads to aberrant splicing, but at the same time creates vulnerability to METTL3 inhibitors.See related article by Wu et al., p. 228 (8) .
iPSC Models of Leukemia Come of Age
Authors: Doulatov Sergei 
Published: April 2023

Summary:
In this issue of Blood Cancer Discovery, Kotini and colleagues present a strategy for large-scale reprogramming of primary human acute myeloid leukemias (AML) to induced pluripotent stem cell (iPSC). They show that the hematopoietic differentiation of AML iPSCs gives rise to transplantable leukemias with remarkable molecular similarity to the original patients’ AML, providing new models and insights into the disease.
See related article by Kotini et al., p. 318 (7) .
SOURCES OF RESISTANCE AND TRICHOME ANALYSIS OF PHILIPPINE INDIGENOUS Hoya SPECIES AGAINST THE MILKWEED APHID, Aphis nerii Boyer De Fonscolombe (HEMIPTERA: APHIDIDAE)
Authors: Cortaga Cris 
Published: April 2023

The Philippines is one of the centers of diversity of Hoya and an extensive collection of indigenous species are conserved at the Institute of Plant Breeding, University of the Philippines Los Baños. In maintaining these Hoya species inside the screenhouse, the major insect pest noted to attack the plants is the milkweed aphid, Aphis nerii Boyer de Fonscolombe. Thus, Hoyas were evaluated for resistance against this insect pest. Among the 45 Hoya species evaluated, 11 showed promising results wherein no aphid infestation was consistently observed during the three evaluation trials. These are H. aurigueana, H. carnosa, H. coriacea, H. diversifolia, H. greenii, H. imperialis, H. madulidii, H. obscura, H. odorata, H. paziae, and H. pubicalyx. As the first line of plants defense against herbivory, we sampled four resistant (H. madulidii, H. pubicalyx, H. carnosa, and H. obscura) and two susceptible (H. buotii and H. meliflua) species for analysis of their trichome traits. The mean trichome length was longest in H. carnosa (0.38mm), followed by H. madulidii (0.33mm), and lastly, H. pubicalyx and H. obscura (0.15mm). Mean trichome density (at 1.64mm2 microscopic field) was highest in H. madulidii (54.45), followed by H. pubicalyx (7.5), and lastly, H. carnosa (3.55) and H. obscura (3.45). In contrast, no trichome was observed in the susceptible species H. buotii and H. meliflua. Hence, trichomes are one of the important resistance traits of Hoya against the milkweed aphid. To our knowledge, this is the first report on resistance evaluation in Hoya and the role of its trichomes against the milkweed aphid. The results of this study can aide in the management of milkweed aphids and in developing improved Hoya cultivars with resistance to insects such as milkweed aphids.
Association of Home Monitoring and Unanticipated Interstage Readmissions in Infants With Hypoplastic Left Heart Syndrome
Authors: Shustak Rachel J. , Faerber Jennifer A. , Stagg Alyson , Hehir David A. , Natarajan Shobha S. , Preminger Tamar J. , Szwast Anita , Rome Jonathan J. , Giglia Therese M. , Ravishankar Chitra , Mercer‐Rosa Laura , Gardner Monique M. 
Published: April 2023

Background
The impact of home monitoring on unanticipated interstage readmissions in infants with hypoplastic left heart syndrome has not been previously studied. We sought to examine the association of our institution's Infant Single Ventricle Management and Monitoring Program (ISVMP) with readmission frequency, cumulative readmission days, and readmission illness severity and to identify patient‐level risk factors for readmission.

Methods and Results

We performed a retrospective single‐center cohort study comparing infants with hypoplastic left heart syndrome enrolled in ISVMP (December 2010–December 2019) to historical controls (January 2007–November 2010). The primary outcome was number of readmissions per interstage days. Secondary outcomes were cumulative interstage readmission days and occurrence of severe readmissions. Inverse probability weighted and multivariable generalized linear models were used to examine the association between ISVMP and the outcomes. We compared 198 infants in the ISVMP to 128 historical controls. Infants in the ISVMP had more than double the risk of interstage readmission compared with controls (adjusted incidence rate ratio, 2.38 [95% CI, 1.50–3.78];
P
=0.0003). There was no difference in cumulative interstage readmission days (adjusted incidence rate ratio, 1.02 [95% CI, 0.69–1.50];
P
=0.90); however, infants in the ISVMP were less likely to have severe readmissions (adjusted odds ratio, 0.28 [95% CI, 0.11–0.68];
P
=0.005). Other factors independently associated with number of readmissions included residing closer to our center, younger gestational age, genetic syndrome, and discharge on exclusive enteral feeds.

Conclusions
Infants in the ISVMP had more frequent readmissions but comparable readmission days and fewer severe unanticipated readmissions. These findings suggest that home monitoring can reduce interstage morbidity without increasing readmission days.
The contribution of theta and delta to feedback processing in children with developmental language disorder
Authors: Gul Asiya , Baron Lauren S. , Arbel Yael 
Published: April 2023

AbstractPurposeThe study aimed at evaluating feedback processing at the electrophysiological level and its relation to learning in children with developmental language disorder (DLD) to further advance our understanding of the underlying neural mechanisms of feedback-based learning in children with this disorder.MethodA feedback-based probabilistic learning task required children to classify novel cartoon animals into two categories that differ on five binary features, the probabilistic combination of which determined classification. The learning outcomes’ variance in relation to time- and time–frequency measures of feedback processing were examined and compared between 20 children with developmental language disorder and 25 age-matched children with typical language development.ResultsChildren with developmental language disorder (DLD) performed poorer on the task when compared with their age-matched peers with typical language development (TD). The electrophysiological data in the time domain indicated no differences in the processing of positive and negative feedback among children with DLD. However, the time–frequency analysis revealed a strong theta activity in response to negative feedback in this group, suggesting an initial distinction between positive and negative feedback that was not captured by the ERP data. In the TD group,deltaactivity played a major role in shaping the FRN and P3a and was found to predict test performance.Deltadid not contribute to the FRN and P3a in the DLD group. Additionally, theta anddeltaactivities were not associated with the learning outcomes of children with DLD.ConclusionThetaactivity, which is associated with the initial processing of feedback at the level of the anterior cingulate cortex, was detected in children with developmental language disorder (DLD) but was not associated with their learning outcomes.Deltaactivity, which is assumed to be generated by the striatum and to be linked to elaborate processing of outcomes and adjustment of future actions, contributed to processing and learning outcomes of children with typical language development but not of children with DLD. The results provide evidence for atypical striatum-based feedback processing in children with DLD.
In-hospital major adverse cardiovascular events after primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction: a retrospective study under the China chest pain center (standard center) treatment system
Authors: Huang Luyao , Zhang Jing , Huang Qing , Cui Ruiqing , Chen Jian 
Published: April 2023

Abstract
Background
Patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) are at high risk of major adverse cardiovascular events (MACE) despite timely treatment. This study aimed to investigate the independent predictors and their predictive value of in-hospital MACE after primary PCI in patients with acute STEMI under the China chest pain center (standard center) treatment system.

Methods
We performed a single-center, retrospective study of 151 patients with acute STEMI undergoing primary PCI. All patients were treated under the China chest pain center (standard center) treatment system. The data collected included general data, vital signs, auxiliary examination results, data related to interventional therapy, and various treatment delays. The primary endpoint was the in-hospital MACE defined as the composite of all-cause death, stroke, nonfatal recurrent myocardial infarction, new-onset heart failure, and malignant arrhythmias.

Results
In-hospital MACE occurred in 71 of 151 patients with acute STEMI undergoing primary PCI. Logistic regression analysis showed that age, cardiac troponin I (cTnI), serum creatinine (sCr), multivessel coronary artery disease, and Killip class III/IV were risk factors for in-hospital MACE, whereas estimated glomerular filtration rate (eGFR), left ventricular ejection fraction (LVEF), systolic blood pressure (SBP), diastolic blood pressure (DBP), were protective factors, with eGFR, LVEF, cTnI, SBP, and Killip class III/IV being independent predictors of in-hospital MACE. The prediction model had good discrimination with an area under the curve = 0. 778 (95%CI: 0.690–0.865). Good calibration and clinical utility were observed through the calibration and decision curves, respectively.

Conclusions
Our data suggest that eGFR, LVEF, cTnI, SBP, and Killip class III/IV independently predict in-hospital MACE after primary PCI in patients with acute STEMI, and the prediction model constructed based on the above factors could be useful for individual risk assessment and early management guidance.
Challenges with the use of Xpert HPV as a screening tool for oral HPV among people living with HIV (PLHIV): experiences from Pune, India
Authors: Admase Abigail , Joshi Samir , Borse Rohidas , Deshpande Prasad , Kulkarni Vandana , Khaire Samir , Thakur Rahul , Chavan Amol , Nimkar Smita , Mave Vidya , Marbaniang Ivan 
Published: April 2023

Abstract
Background
People living with HIV (PLHIV) are at higher risk for human papillomavirus (HPV)-related oropharyngeal cancers compared to the general population. Xpert HPV test is a polymerase chain reaction (PCR) assay capable of rapid HPV detection. Performing the assay requires minimal intervention by laboratory personnel. Its use could improve oropharyngeal cancer screening among PLHIV living in low-and middle-income countries (LMICs) with limited diagnostic capacities. However, Xpert HPV performance for oral samples has not been evaluated. Here, we describe our experience with Xpert HPV and compare its results with traditional PCR, for oral samples.

Methods
Oral samples from 429 PLHIV receiving care at a tertiary care hospital affiliated antiretroviral therapy center in Pune, India were used. Samples were collected either after a 30s oral rinse and gargle (n = 335) or in combination with cytobrush scraping of the oral mucosa (n = 91). Unsuccessful tests were those that generated an invalid or error result on Xpert HPV. Successful tests were those that generated a positive or negative result. Kappa statistic was used to compare concordance between Xpert HPV and traditional real-time PCR results.

Results
There were 29.8% (n = 127) unsuccessful tests, of which 78.7% (n = 100) were invalid and 21.3% (n = 27) were error results. Adding cytobrush scraping to oral rinse as a collection procedure did not significantly reduce the proportion of unsuccessful tests (p = 0.9). For successful tests, HPV positivity on Xpert was 0.3% (n = 1/299). Kappa statistic was 0.11, indicating poor agreement between Xpert HPV and traditional PCR results.

Conclusions
Presently, Xpert HPV appears to have limited use for oral HPV detection among PLHIV using oral samples. More research to improve the diagnostic capabilities of Xpert HPV for oral samples among PLHIV is needed.