bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Two Different Types of Music Played to Cancer Patients During Chemotherapy on Anxiety, Nausea, and Satisfaction Levels
Authors: DALLI Öznur ERBAY , DOĞAN Derya AKÇA , PEHLİVAN Seda , YILDIRIM Yasemin , EVRENSEL Türkkan 
Published: July 2023

Abstract
Purpose: To investigate the effect of two different types of music on anxiety, nausea, and satisfaction levels in cancer patients receiving chemotherapy (CT) for the first time.
Methods: The study was conducted as a single-blind, pre-test, post-test, three-group randomized controlled trial in an outpatient CT unit between August 2022 and February 2023. A simple (computer-based) and stratified (age and gender) randomization method was used to assign 75 patients to the relaxing music group (RMG), Turkish classical music group (TCMG), and control group (CG) (n=25 each). The primary outcome was the change in anxiety levels measured by Spielberger's State Anxiety Inventory before (T0) and after (T1) CT session. Secondary outcomes were the change in the severity of nausea from T0 to T1 and the level of satisfaction at T1.
Results: The groups were similar in terms of baseline sociodemographic and health-related characteristics. Anxiety levels were lower than the baseline in RMG and TCMG in comparison to CG, and repeated measures analysis showed a significant group × time interaction (p=0.001, F=210.221, η2=0.745). Nausea severity increased from T0 to T1 for CG but decreased for RMG and TCMG with a significant group × time interaction (p=0.001, F=100.785, η2=0.583). The satisfaction level was significantly higher in TCMG than in CG and RMG (8.64±0.95 vs. 7.88±0.72 and 7.00±0.70, respectively).
Conclusion: Music may be an effective non-pharmacologic option to relieve patients' anxiety and nausea during first-time CT, irrespective of music type. Larger, multicenter studies evaluating the long-term effect of music are needed to confirm these findings.
Trial registration number/date: clinicaltrials.gov (NCT05687838) / 2022-13/18
Myofascial Induction Technique changes Plantar pressures variables compared to a Simulated Laser. A randomized single-blind trial
Authors: Martinez-Jiménez Eva María , Losa-Iglesias Marta Elena , Becerro-de-Bengoa-Vallejo Ricardo , Rodriguez-Sanz David , López-López Daniel , Romero-Morales Carlos , Painceira-Villar Roi , Calvo-Lobo Cesar 
Published: July 2023

Abstract
Background: The fascial system is made up of large number of mechanoreceptors and cells that regulate their tension, such as myofibroblasts, in addition to an extracellular matrix. The treatment of myofascial induction has shown in the static imprint in a quasi-experimental study comparing the effect before and after the technique, but there are no studies compared with a control with no real intervention. The objective of this research is to check the effects of the myofascial Induction traction technique, compared with a simulated Laser in plantar footprint variables in asymptomatic subjects.
Methods.Thirty-six healthy participants were recruited to carry out a single-blind clinical study in randomizated two groups. Experimental intervention group performed a bilateral plantar fascia of Myofascial Induction technique. Control intervention group performed a simulated Laser. The time of application of the techniques were 5 minutes for both interventions. The variables recorded were Surface, mean pressure and maximum pressure for each region of the foot, rear foot, midfoot and fore foot.
Results. Both groups were homogeneous prior to the interventions. The significant differences found later were in the forefoot surface variable (p =0.026) where there was an increase in the area in the experimental group.
Conclusions. The myofascial induction technique shows effects on the static plantar footprint by increasing the surface of the forefoot compared to the application of a simulated laser. Registration in ClinicalTrial.gov (ID: NCT04628299) Registered in clinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT04628299
Risk factors associated with ulcerative colitis: A multidimensional case-control study from Tianjin, China
Authors: Song Jiachun , Wang Shuyuan , Yuan Zhen , Wang Wanting , Yan Suying , Liu Xinyu , Yi Ben , Han Qiurong , Yao Yao , Liu Yanfei , Chu Tianhao , Feng Zhiqiang , Xue Jun , Zhang Qinghuai , Zhang Xipeng , Zhang Chunze 
Published: July 2023

Abstract
Background and study aims
Although ulcerative colitis (UC) incidence is increasing in China, there are few reports on risk factors. We conducted a case‒control study in Tianjin, China, to assess potential risk factors for the development, extent and severity of UC.
Methods
361 UC patients and 1444 controls with similar social backgrounds were screened by detailed questionnaires and corresponding endoscopic findings in Tianjin's colorectal cancer screening program from 2012 to 2020. Basic demographic characteristics were compared using the chi-square test, and multivariate analysis was conducted by conditional logistic regression models.
Results
Multivariate analysis showed the risk factors for UC were male sex (OR = 1.83, 95% Cl: 1.27-2.63) and history of mucus and blood in stool (OR = 3.25 95% Cl: 2.24 4.68). For lesion extent and lesion severity, men and patients with history of mucus and blood in stool were more likely to have larger and more severe UC lesions. Advanced age, BMI≥25, current smoking status, regular exercise, a history of first-degree relatives with bowel cancer, and a history of chronic constipation were indicated as protective factors for UC.
Conclusions
Our study demonstrates that different environmental factors influence different clinical pathways in the initiation and progression of UC. Avoidance of environmental variables associated with disease risk leads to better clinical outcomes.
APareto Optimal Strategy Based on Multi-objective Optimization for the Clinching Tools
Authors: xu fan , Gao Ming , Ma Chao , Zhao Huiyan , Zhu Jianxiong , Zhang Zhen 
Published: July 2023

Abstract
The geometric size of the clinching tools determines the geometric size and strength of the clinched joint. This study establishes an orthogonal analysis experimental plan to examine how a group of geometric size of the tool affects the objective functions of a clinched joint, including its bottom thickness, necking thickness and interlocking thickness. Particularly, the study evaluates the effects of die radius, die depth, punch stroke, punch radius and punch fillet on the geometric size of the clinched joint. A multiple quadratic regression model is used to quantitatively analyze the contribution value of the feature parameters of the tool to the objective function. Furthermore, a multi-objective genetic algorithm based on the Pareto solution is used to solve the multiple quadratic regression model, and the optimal combination size of the tool is determined by comparing theoretical and simulation calculations. The optimal die radius is 4.6 mm, the die height is 1.10 mm, the punch stroke is 4.1 mm, the punch is 2.6 mm and the punch filled is 0.5mm. These parameters are used to manufacture a pair of tool for improving the clinched joint quality.
Effect of Atmospheric Cold Plasma (ACP) Treatment on Zein-Thymol Composite Particles: Enhanced Encapsulation Efficiency
Authors: Dong Shuang , Li Xiaoyu , Wang Tian , Wang Yaxiao , Li Ruihong , Jing Chengtong , Tu An , Guo Peng 
Published: July 2023

Abstract
The atmospheric cold plasma (ACP) treatment was applied in this study to assist the preparation of zein-thymol (ZT) composite particles and the effects under different ACP treatment power were studied. The results showed the encapsulation efficiency (EE) of ZT composite particles was significantly increased from 39.61 ± 2.78% (untreated) to the maximum of 80.35 ± 5.91% (ACP-50 W). The plasma-treated ZT composite particles exhibited higher Z-potential, conductivity, and surface hydrophobicity, especially for samples treated under 50 ~ 60 W. Micro-structural analysis showed that plasma induced disruption of α-helix packing order and increased content of β-sheet and β-turn, accompanied by more formation of disulfide bonds. Results suggested that the reinforcement of hydrogen bonding force, hydrophobic interaction and electrostatic interaction between zein and thymol were accounting for the increased EE of ZT particles treated via ACP. This study opens up new opportunities that ACP could be developed as an effective assisting approach in preparation of zein-based nutrient substance delivery systems.
Assessing the role of socio-demographic characteristics, social support and formal disaster assistance in predicting the subjective recovery of flood survivors in Pakistan
Authors: Akbar Muhammad Siddique , Aldrich Daniel P. 
Published: July 2023

Abstract
This study investigates the effects of socio-demographic characteristics of the 2010 flood victims, their flood exposure, and social and formal support on the post-flood subjective recovery. It seeks to illuminate the factors best correlating with life recovery feelings of the respondents. Regression analysis of survey data showed that period of return to home, annual income, family size, material damage and social support had a significant effect on the life recovery of the respondents. More specifically, the period of return to home and material loss had a negative effect on the life recovery feelings of flood victims. Annual income of the respondents, family size and social support had a positive effect on their life recovery feelings. Analysis also revealed that formal disaster support had a very negligible effect on life recovery. Furthermore, the analysis uncovered that social support helped to lessen the negative effects of material damage on the life recovery feelings of the survivors. The effects of annual income on life recovery feelings remained almost constant and significant in all the regression models, showcasing the importance of personal resources to recover from disaster. The study concludes that although both social and formal support are pivotal for post-flood subjective recovery, they are characterized by serious limitations. More nuanced longitudinal studies are required to understand the contours of long term disaster recovery process.
Knowledge, Perceptions, and Beliefs About Urinary Tract Infections in Persons with Neurogenic Bladder and Impacts on Interventions to Promote Person-centered Care
Authors: Fitzpatrick Margaret , Solanki Pooja , Wirth Marissa , Weaver Frances , Suda Katie , Burns Stephen , Safdar Nasia , Collins Eileen , Evans Charlesnika 
Published: July 2023

Abstract

Study Design: Qualitative Study
Objective:
To explore how knowledge, perceptions, and beliefs about urinary tract infections (UTIs) among persons with neurogenic bladder (NB) may impact health behaviors and provider management and enhance person-centeredness of interventions to improve UTI management.
Setting: Three Veterans Affairs (VA) medical centers
Methods:
Adults with NB due to spinal cord injury/disorder (SCI/D) or multiple sclerosis (MS) with UTI diagnoses in the prior year participated in focus groups. Transcripts were coded using deductive codes linked to the Health Belief Model and inductive codes informed by grounded theory.
Results:
Twenty-three Veterans (SCI/D, 78%; MS: 18.5%) participated in discussions. Three themes emerged: 1) UTI knowledge; 2) factors affecting the intervention environment; and 3) factors affecting modes of delivery. Knowledge gaps included UTI prevention, specific symptoms most indicative of UTI, and antibiotic side effects. Poor perceptions of providers lacking knowledge about NB and ineffective patient-provider communication were common in the Emergency Department and non-VA facilities, whereas participants had positive perceptions of home-based care. Participants perceived lower severity and frequency of antibiotic risks compared to UTI risks. Participant preferences for education included caregiver involvement, verbal and written materials, and diverse settings like peer groups.
Conclusions:
Identifying patient perspectives enhances person-centeredness and allows for novel interventions improving patient knowledge and behaviors about UTIs. Partnering with trusted providers and home-based caregivers and improving NB knowledge and communication in certain care settings were important. Patient education should address mental risk representations and incorporate preferences for content delivery to optimize self-efficacy and strengthen cues to action.
Assessment of Diagnostic Assays for Visceral Leishmaniasis: A Diagnostic Test Validation Study
Authors: Filho Job Alves de Souza , Mol Marcos Paulo Gomes , Medeiros Fernanda Alvarenga Cardoso 
Published: July 2023

Abstract
Introduction: Visceral leishmaniasis (VL) requires diagnostic assays to complement clinical suspicion. However, there is no standardization of a diagnostic flow using available assays. This study aims to evaluate the performance of parasitological, molecular, and serological assays for diagnosing VL and propose a diagnostic flow based on performance, practicality, and invasiveness.
Methods: We conducted a diagnostic test validation study of 10-year (2010-2020) routine diagnoses of VL at the Brazilian National Reference Laboratory.
Results: We propose a diagnostic flow where individuals suspected of VL are initially screened using an immunochromatographic test (ICT) with rK39 antigen on the nitrocellulose membrane. This is followed by a blood polymerase chain reaction (PCR) for Leishmania sp. kDNA, and direct parasitological exam and/or PCR in bone marrow aspirate. A positive result in any of these assays can define a VL case. If clinical suspicion persists in negative individuals, the diagnostic flow should be repeated.
Conclusions: The proposed flow has the potential to standardize and improve the diagnosis of VL. It reduces the need for invasive tests without compromising diagnostic accuracy.
Improving Association Discovery throughMultiview Analysis of Social Networks
Authors: Shebaro Muhieddine , de Moura Lia Nogueira , Tešić Jelena 
Published: July 2023

Abstract

The rise of social networks has brought about a transformative impact on communication and the dissemination of information. However, this paradigm shift has also introduced many challenges in discerning valuable conversation threads amidst fake news, malicious accounts, background noise, and trolling. In this study, we address these challenges by focusing on propagating fake news labels. We evaluate the efficacy of community-based modeling in effectively addressing these challenges within the context of social network discussions using the state-of-art benchmark. Through a comprehensive analysis of millions of users engaged in discussions on a specific topic, we unveil compelling evidence demonstrating that community-based modeling techniques yield precision, recall, and accuracy levels comparable to those achieved by lexical classifiers. Remarkably, these promising results are achieved even without considering the textual content oftweetsbeyond the information conveyed by hashtags. Moreover, we explore the effectiveness of fusion techniques in tweet classification and underscore the superiority of a combined community and lexical approach, which consistently delivers the most robust outcomes and exhibits the highest performance measures. We illustrate this capability with specific network graphs constructed based on Twitter interactions related to the COVID-19 pandemic, showcasing the practicality and relevance of our proposed methodology.
Stromal Myofibroblasts in Correlation With Inflammation and Impacted Tooth in Odontogenic Cysts: An Immunohistochemical Comparative Study
Authors: Martins Karina Helen , Barbeiro Camila de Oliveira , Barbeiro Roberto Henrique , Anbinder Ana Lia , Guardia Rafaella Souza , Silva Evânio Vilela , Reyes Magdalena Raquel Torres , Javaroni Júlia Biliato , Esquiche Jorge , de Rossi Andiara 
Published: July 2023

AbstractAim Stromal myofibroblasts may act favoring growth and progression of odontogenic lesions, notably odontogenic keratocyst (OKC). While little explored the associated inflammation, it has been shown that OKC associated with an impacted tooth has a tendency toward rapid growth. Whether this finding is associated with the differential expression of myofibroblast immunomarkers, is unknown. Materials and methods Thirteen cases of each, pericoronal follicle (PF), inflamed dentigerous cyst (iDC), noninflamed DC (nDC), OKC associated with (OKC-A) or not associated (OKC-N) with impacted tooth, were evaluated through vimentin, α-SMA, calponin and h-caldesmon immunomarkers The data obtained were analyzed using the Shapiro-Wilk, Kruskal-Wallis and Dwass-Steel-Critchlow-Fligner Multiple Comparisons tests, with p < 0.05 being considered statistically significant. Results All cases were vimentin positive, with few cases exhibiting mild expression. All PFs were α-SMA negative. OKCs showed significant higher expression of α-SMA than DCs (p < 0.05). With similar expression between DC groups, the α-SMA expression was higher in OKC-A than OKC-N (p = 0.882). Also, the mean age of OKC-A was significantly lower than OKC-N patients. Only 4 cases (1 iDC, 3 OKC-N) showed mild expression of calponin. All cases were h-caldesmon negative. Conclusions Our results suggest lack of myofibroblastic differentiation in PFs. Inflammation does not seem to influence the myofibroblast population in DCs. Although not significant, a higher expression of α-SMA can explain the clinicopathological features of OKC-A patients. Calponin seems not to be a reliable marker for myofibroblasts in these cases. Clinical relevance Lack of myofibroblastic differentiation seems to be consistent with the nature and function of PF. OKC (still, OKC-A than OKC-N) presents higher α-SMA expression than DC, which can help to explain its distinctive growth potentials.
Evaluation of a smartphone electrocardiograph in healthy foals and comparison to standard base-apex electrocardiography
Authors: Bindi Francesca , Vezzosi Tommaso , Sala Giulia , Freccero Francesca , Marmorini Paola , Bonelli Francesca , Sgorbini Micaela 
Published: July 2023

Abstract
Smartphone-based technology for ECG recording has recently spread as a complementary tool for electrocardiographic screening and monitoring in adult horses and in other animal species. The present study aimed to assess the feasibility and accuracy of a smartphone-based ECG in healthy foals. This was a prospective observational study (authorization n. 45865/2016) including 22 foals aged less than 21 days. A reference standard base-apex ECG (rECG) was acquired, and a smartphone ECG (sECG) was recorded immediately after by using a smartphone-based single lead electrocardiograph. All ECG tracings were evaluated in a blind fashion by a single board-certified cardiologist, who judged whether the tracings were acceptable for interpretation and performed ECG measurements and diagnosis. The Spearman correlation coefficient, the Cohen’s k test and the Bland-Altman test were used to assess the agreement between sECG and rECG. All sECG tracings were acceptable for interpretation. All foals showed sinus rhythm on both rRCG and sECG tracings, with perfect agreement in heart rate classification (κ = 0.87; p < 0.001). No clinically relevant differences were found in the assessment of waves and intervals duration. Concerning P wave and QRS complex polarity, the percentage of agreement between rECG and sECG was 78% and 83%, respectively. About ECG tracing quality, rECG and sECG showed a substantial agreement (κ = 0.624; p < 0.001). In conclusion, the smartphone-based ECG device tested in the present study recorded good quality single-lead ECG tracings in foals, reliable for heart rate and ECG measurements, but different polarity of P waves and QRS complexes was found in some foals in comparison to rECG.
Analysis of protein secretion in Bacillus subtilis by combining a secretion stress biosensor strain with an in vivo split GFP assay
Authors: Lenz Patrick , Bakkes Patrick J. , Müller Carolin , Malek Marzena , Freudl Roland , Oldiges Marco , Drepper Thomas , Jaeger Karl-Erich , Knapp Andreas 
Published: July 2023

Abstract
Background
Bacillus subtilis is one of the workhorses in industrial biotechnology and well known for its secretion potential. Efficient secretion of recombinant proteins still requires extensive optimization campaigns and screening with activity-based methods. However, not every protein can be detected by activity-based screening. We therefore developed a combined online monitoring system, consisting of an in vivo split GFP assay for activity-independent target detection and an mCherry-based secretion stress biosensor. The split GFP assay is based on the fusion of a target protein to the eleventh β-sheet of sfGFP, which can complement a truncated sfGFP that lacks this β-sheet named GFP1-10. The secretion stress biosensor makes use of the CssRS two component quality control system, which upregulates expression of mCherry in the htrA locus thereby allowing a fluorescence readout of secretion stress.
Results
The biosensor strain B. subtilis PAL5 was successfully constructed by exchanging the protease encoding gene htrA with mCherry via CRISPR/Cas9. The Fusarium solani pisi cutinase Cut fused to the GFP11 tag (Cut11) was used as a model enzyme to determine the stress response upon secretion mediated by signal peptides SPPel, SPEpr and SPBsn obtained from naturally secreted proteins of B. subtilis. An in vivo split GFP assay was developed, where purified GFP1-10 is added to the culture broth. By combining both methods, an activity-independent high-throughput method was created, that allowed optimization of Cut11 secretion. Using the split GFP-based detection assay, we demonstrated a good correlation between the amount of secreted cutinase and the enzymatic activity. Additionally, we screened a signal peptide library and identified new signal peptide variants that led to improved secretion while maintaining low stress levels.
Conclusion
Our results demonstrate that the combination of a split GFP-based detection assay for secreted proteins with a secretion stress biosensor strain enables both, online detection of extracellular target proteins and identification of bottlenecks during protein secretion in B. subtilis.
Interrogating Random and Systematic Measurement Error in Morphometric Data
Authors: Collyer Michael L , Adams Dean c 
Published: July 2023

Abstract
Measurement error is present in all quantitative studies, and ensuring proper biological inference requires that the effects of measurement error are fully scrutinized, understood, and to the extent possible, minimized. For morphometric data, measurement error is often evaluated from descriptive statistics that find ratios of subject or within-subject variance to total variance for a set of data comprising repeated measurements on the same research subjects. These descriptive statistics do not typically distinguish between random and systematic components of measurement error, even though the presence of the latter (even in small proportions) can have consequences for downstream biological inferences. Furthermore, merely sampling from subjects that are quite morphologically dissimilar can give the incorrect impression that measurement error (and its negative effects) are unimportant. We argue that a formal hypothesis-testing framework for measurement error in morphometric data is lacking. We propose a suite of new analytical methods and visualization tools that more fully interrogate measurement error, by disentangling its random and systematic components, and evaluating any group-specific systematic effects. Through the analysis of simulated and empirical data sets we demonstrate that our procedures properly parse components of measurement error, and characterize the extent to which they permeate variation in a sample of observations. We further confirm that traditional approaches with repeatability statistics are unable to discern these patterns, improperly assuaging potential concerns. We recommend that the approaches developed here become part of the current analytical paradigm in geometric morphometric studies. The new methods are made available in the RRPP and geomorph R-packages.