bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning from long‐term adolescent and young adult (AYA) cancer survivors regarding their age‐specific care needs to improve current AYA care programs
Authors: Janssen Silvie H. M. , Vlooswijk Carla , Manten‐Horst Eveliene , Sleeman Sophia H. E. , Bijlsma Rhodé M. , Kaal Suzanne E. J. , Kerst Jan Martijn , Tromp Jacqueline M. , Bos Monique E. M. M. , van der Hulle Tom , Lalisang Roy I. , Nuver Janine , Kouwenhoven Mathilde C. M. , van der Graaf Winette T. A. , Husson Olga 
Published: April 2023

AbstractBackgroundDespite growing (inter)national awareness and appreciation, age‐specific care is still not always self‐evident and accepted as standard of care for adolescent and young adult (AYA) cancer patients. It is unknown whether long‐term AYA cancer survivors have missed age‐specific care, and if so, which survivors missed it and regarding which topics.MethodsThe Netherlands Cancer Registry (NCR) identified all long‐term AYA cancer survivors (aged 18–39 years at initial cancer diagnosis, 5–20 years past diagnosis) in the Netherlands, who were invited to participate in a population‐based, observational, cross‐sectional questionnaire study (SURVAYA study), including questions on care needs.ResultsIn total, 3.989 AYAs participated (35.3% response rate). One‐third of them had a need for age‐specific care (33.5%), 41.2% had no need and 25.3% did not know whether they had a need. Those who had a need for age‐specific care were significantly more often female, higher educated, diagnosed at a younger age, and treated with chemotherapy, radiotherapy or hormone therapy. Most frequent topics were disease and treatment (29.7%), emotions (24.1%), friends (22.6%), family and children (15.6%), fertility and pregnancy (14.8%), work and reintegration (10.5%), care not tailored (13.8%), and overarching care and life (27.7%). Palliative care (0.0%), spirituality (0.2%), death (0.7%), complementary care (0.7%), and late effects (1.3%) were mentioned least.ConclusionsA substantial proportion of long‐term AYA cancer survivors showed a need for age‐specific care, varying by sociodemographic and clinical factors, on a wide variety of topics, which could be targeted to improve current AYA care services.
A review of safeguarding in grassroots football: Children and young people's perspectives
Authors: Monk Claire 
Published: April 2023

AbstractIn 2021, Birmingham County Football Association (BCFA) in partnership with Newman University carried out a quantitative online review to assess coaches, volunteers, parents and young people's understanding of safeguarding information, policies and procedures in relation to football. This paper examines the findings from the children (aged 5–11) and young people (aged 12–17) using the Six Principles of Safeguarding to assess the current safeguarding measures in place to protect children and young people (CYP) playing grassroots football. The review found that whilst most CYP felt safe when playing organised football, there were some concerns raised from the young people in relation to angry parents, abuse and racism. Most children in both groupings had heard of the term safeguarding, but fewer had heard of the term welfare, and struggled to explain what welfare meant. A key finding and concern is that many CYP are not aware of the role of the Club Welfare Officer at their football club or that this might be someone to whom they can disclose issues concerning them. Furthermore, it became evident that further research, awareness raising and implementation of listening to and acting on children's voices needs to be fully embedded into safeguarding practice in children and young people's organised football.
Indolocarbazole‐Based Multiple‐Resonance Molecules: an Emerging Class of Full‐Color, Narrowband Emitters for Organic Light‐Emitting Diodes
Authors: Wang Xiang , Duan Lian , Zhang Dongdong 
Published: April 2023

AbstractNarrowband emitters based on the multiple resonance (MR) effect have shown great promises for applications in high‐definition displays. Though most reported MR emitters adopt the boron‐ and nitrogen‐doped triangulene‐like skeleton following the design of the DABNA series, MR materials with the nitrogen‐only indolocarbazole structures have recently emerged and demonstrated good color tunability from violet to deep red and impressive electroluminescence performances in terms of both efficiency and stability. Herein, we will summarize indolocarbazole‐based MR materials in recent reports, with emphasis on their molecular design, synthesis, photophysical and electroluminescence properties as well as some future research directions to unlock the full potential of this fascinating class of materials.
Selective Nsp2‐ and Csp2‐ Photografting of Au‐Surface by Aryldiazonium Salts and Arylazo Sulfonates
Authors: Nicchio Luca , Médard Jérôme , Decorse Philippe , Gam‐Derouich Sarra , Chevillot‐Biraud Alexandre , Luo Yun , Mangeney Claire , Berisha Avni , Averseng Frédéric , Fagnoni Maurizio , Protti Stefano , Pinson Jean 
Published: April 2023

AbstractArylazo sulfonates (Ar−N=N−SO3Na) have been found to undergo photografting on gold surface through both Au−Nsp2− and Au−Csp2− bond formation. The functionalized materials have been fully characterized by infrared reflection absorption spectroscopy (IRRAS), Raman, XPS, DFT calculations and UV‐Vis absorption spectroscopy. These methods permit to evidence aromatic substituents (IRRAS), the Au−N=N signature (Raman and XPS spectroscopy), and the bond dissociation energy values of the two linkages (DFT calculation). The grafting proceeds through two competitive paths, namely a stepwise reaction involving an aryl radical (for the formation of the Au−Ar bonds) and a concerted reaction on the surface of gold (for Au−N=N−Ar bond formation). The occurrence of an aryl radical upon irradiation has been fully evidenced by EPR spectroscopy. Finally,E/Zphotoisomerisation of the N=N bonds present on prepared few layer films has been observed by means of UV‐Vis absorption spectroscopy.
Association of polypharmacy with all‐cause mortality and adverse events among elderly colorectal cancer survivors
Authors: Choi Dong‐Woo , Kang Hyejung , Zhang Hyun‐Soo , Jhang Hoyol , Jeong Wonjeong , Park Sohee 
Published: April 2023

AbstractBackgroundThe risk of inappropriate drug exposure in elderly colorectal cancer (CRC) survivors after the initial cancer treatment has not been well studied. This study investigated the association of polypharmacy (PP) with overall survival, hospitalization, and emergency room (ER) visits among older CRC survivors.MethodsA retrospective cohort study was conducted using the Korean National Health Insurance claims data follow‐up from 2002 to 2017. Participants comprised those aged ≥65 years who were hospitalized with a diagnosis of CRC received cancer treatment and survived at least 2 years from the initial CRC diagnosis between 2003 and 2012. PP was defined based on the number of individual drugs during the third year, after 2 years of survival since the initial cancer treatment. PP was categorized as follows: non‐PP (zero to four prescribed drugs); PP (five to nine drugs), and excessive PP (≥10 drugs). Main outcomes are all‐cause mortality, hospitalization, and ER visits.ResultsOf the 55,228 participants, 44.5% died, 83.1% were hospitalized, and 46.1% visited the ER. The PP and excess PP groups showed increased risk of all‐cause mortality, hospitalization, and ER visit compared with the low PP group, and was highly associated among groups including patients aged 65 to 74 years and those in low‐level frailty groups.ConclusionsThese risks can be minimized by increasing awareness and enhancing behaviors among health care professionals, especially clinician and pharmacists, to be aware of potential drug interactions, review, and ongoing monitoring.Plain Language Summary

The risk of inappropriate drug exposure in older colorectal cancer (CRC) survivors after the initial cancer treatment has not been well studied.
Polypharmacy was associated with adverse outcomes, including all‐cause mortality, hospitalization, and emergency room visits among older CRC survivors and it was particularly associated with those who were 65 to 75 years and those with low risk of frailty.
When prescribing drugs, physicians should be mindful of finding a balance between adequate treatment of diseases and avoiding adverse drug effects in survivors of CRC.
The dorsal stream of visual processing and action‐specific domains in parietal and frontal cortex in primates
Authors: Stepniewska Iwona , Kaas Jon H. 
Published: April 2023

AbstractThis review summarizes our findings obtained from over 15 years of research on parietal–frontal networks involved in the dorsal stream of cortical processing. We have presented considerable evidence for the existence of similar, partially independent, parietal–frontal networks involved in specific motor actions in a number of primates. These networks are formed by connections between action‐specific domains representing the same complex movement evoked by electrical microstimulation. Functionally matched domains in the posterior parietal (PPC) and frontal (M1‐PMC) motor regions are hierarchically related. M1 seems to be a critical link in these networks, since the outputs of M1 are essential to the evoked behavior, whereas PPC and PMC mediate complex movements mostly via their connections with M1. Thus, lesioning or deactivating M1 domains selectively blocks matching PMC and PPC domains, while having limited impact on other domains. When pairs of domains are stimulated together, domains within the same parietal–frontal network (matching domains) are cooperative in evoking movements, while they are mainly competitive with other domains (mismatched domains) within the same set of cortical areas. We propose that the interaction of different functional domains in each cortical region (as well as in striatum) occurs mainly via mutual suppression. Thus, the domains at each level are in competition with each other for mediating one of several possible behavioral outcomes.
Bridging molecular genetics and genomics for cotton fiber quality improvement
Authors: Naoumkina Marina , Kim Hee Jin 
Published: April 2023

AbstractUpland cotton (Gossypium hirsutum L.) is the main source of natural fiber for the textile industry. Cotton fibers are unicellular trichomes that emerge from the epidermal cells of the seed. In cultivated cotton species, seed trichomes differentiate into two distinct types, spinnable lint, and short fuzz. The main priority for cotton growers is fiber yield, whereas the textile industry also demands better fiber quality characteristics, such as length, uniformity, strength, maturity, and optimal fineness. However, it is a major challenge for breeders to improve fiber quality while maintaining yield, because of the observed negative correlation between yield and fiber quality traits. Recent technical advances in sequencing and bioinformatics have facilitated the assembly of reference quality genomes of multiple cotton species, bringing a new era for cotton genomics. Available genomic resources will help genetically dissect the agronomic and fiber quality traits of cotton and identify gene variants that can be used for cotton improvement through breeding or biotechnology. Here, we review recent progress in the sequencing of genomes of cotton species and approaches in molecular genetics and genomics for the improvement of cotton fiber quality traits. We discuss progress in the understanding of each stage of cotton fiber development and the remaining challenges.
Vulnerability assessment of peatland complexes in the Hudson Plains (Ontario, Canada) to permafrost‐thaw‐induced landcover and hydrological change using a multiscale approach
Authors: Mack Mikhail , Quinton William , McLaughlin James , Hopkinson Christopher 
Published: April 2023

AbstractThe Hudson Plains, Canada, is one of the largest, undisturbed peatland regions (370,000 km2) in the world. Air temperature in the Hudson Plains is increasing rapidly leading to unprecedented permafrost thaw. The region's remoteness has hindered our knowledge of how permafrost thaw alters peatland land cover and hydrological response at multiple scales. To assess which landscapes in the Hudson Plains are vulnerable to such disturbances, we analysed latitudinal distributions of land cover over a 300‐km transect spanning the sporadic (<30% areal) to continuous (>80% areal) permafrost zone in northern Ontario and quantified land cover changes over 40 years using multiple remote sensing datasets (lidar, air photographs, and high‐resolution satellite imagery). We then evaluated these landscapes at a fundamental hydrological unit, the peatland complex, identified five peatland complex types, and conceptualized their potential hydrological response using circuitry analogues. Over four decades, we found that permafrost peatlands declined by 4%, 8.5%, and 2% areal in the sporadic, discontinuous, and continuous permafrost zones, respectively. Circuitry analogues partitioned peatland complexes into their component peatland forms (e.g., permafrost peatland, bog, and fen) and represented each component's hydrological function using an electrical equivalent (e.g., generator, switch, and conductor). When interpreted at the landscape scale, circuitry analogues demonstrated latitudinal patterns in landscape structure (i.e., circuitry wiring) and indicated where permafrost thaw will have the greatest impact on landscape structure (i.e., rewiring) and therefore hydrological response. Based on these analyses, we suggest a 60‐km latitudinal segment (54.5°N to 54.9°N) where peatland complexes are most vulnerable to permafrost‐thaw‐induced land cover and hydrological change and should therefore be the focus of future research and monitoring efforts.
Evaluation of global biogeochemical cycle in lotic and lentic waters by developing an advanced eco‐hydrologic and biogeochemical coupling model
Authors: Nakayama Tadanobu 
Published: April 2023

AbstractRecent research suggests reservoirs and dams have a great impact on the transformation of the carbon cycle in inland water. The author so far developed an advanced model coupling eco‐hydrology with biogeochemical cycle [National Integrated Catchment‐based Eco‐hydrology (NICE)‐BGC] and applied it to river basins to include the effect of global major reservoirs on biogeochemical cycles. In the present study, he extended NICE‐BGC to couple with LAKE2K in a stratified water quality model to evaluate the global biogeochemical cycle in lotic and lentic waters. Simulated water levels agreed with reasonably observed values there, which means that hydrologic budgets were simulated correctly. Simulated particulate organic carbon (POC) flux was relatively in good agreement with the author's previous study, whereas dissolved organic carbon (DOC) flux was not highly correlated. This result means that there are limits to the application of the same partial differential equations as in inorganic carbon for derivatives either with or without reservoirs as assumed by the author's previous study. Further, the result showed the difference in DOC flux has a positive relation and that of POC flux has a negative relation with nutrient concentrations. The simulated result also implies the amount of transformation from POC to DOC increases as the nutrient concentration increases in lentic water. Finally, the author evaluated changes in the global carbon cycle due to anthropogenic factors such as the construction of artificial dams with nutrient concentrations in lentic water. These findings provide valuable insights for re‐evaluation of carbon cycle change because the changes of fluxes in lentic waters rather depend not only on the difference in water level or discharge but also on retention time, nutrient conditions and water temperature.
How resilience is framed matters for governance of coastal social‐ecological systems
Authors: Clement Sarah , Jozaei Javad , Mitchell Michael , Allen Craig R. , Garmestani Ahjond S. 
Published: April 2023

AbstractEffective governance of social‐ecological systems (SES) is an enduring challenge, especially in coastal environments where accelerating impacts of climate change are increasing pressure on already stressed systems. While resilience is often proposed as a suitable framing to re‐orient governance and management, the literature includes many different, and sometimes conflicting, definitions and ideas that influence how the concept is applied, especially in coastal environments. This study combines discourse analysis of the coastal governance literature and key informant interviews in Tasmania, Australia, demonstrating inconsistencies and confusion in the way that resilience is framed in coastal governance research and practice. We find that resilience is most often framed as (1) a rate of recovery from disturbance or (2) the process of acting in response to, or anticipation of, a disturbance. A third framing considers resilience as an emergent property of SESs. This framing, social‐ecological resilience, accounts for multiple configurations of SES, which necessitates adaptation and transformation strategies to address changes across temporal and spatial scales. Coastal managers recognised the value of this third framing for governing coastal SESs, yet the confusion and inconsistency in the literature was also evident in how they understood and applied resilience in practice. Expanding the use of social‐ecological resilience is essential for more effective coastal governance, given the dynamics of coastal SESs and the intensity of social, economic, and environmental drivers of change these systems face. However, this requires addressing the unclear, confused, and superficial use of resilience‐oriented concepts in research and policy discourse.
Copper‐Catalyzed Intramolecular SEAr Reaction–Oxidation under Aerobic Conditions: Synthesis of Styryl‐/Alkenyl‐Substituted Xanthone Derivatives
Authors: Yadav Sanjay , Kumar Sinha Prashant , Suresh Surisetti 
Published: April 2023

AbstractHerein, we report a copper‐catalyzed intramolecular electrophilic aromatic substitution (SEAr)−oxidation process to access a wide range of diversified xanthone derivatives using air as a sole oxidant. Specifically, this protocol affords hitherto unknown styryl‐/alkenyl‐substituted xanthone derivatives in moderate to high yields. The practicality of the method has been demonstrated by gram‐scale syntheses.
Serine, glutamate, and proline in a high‐fat diet exacerbated metabolite reduction‐induced memory and cognitive decline
Authors: Zhang Miao , Shan Kai , Song Shangxin , Bai Juan , Jiang Ping , Zhao Di , Ke Weixin , Zhou Guanghong , Li Chunbao 
Published: April 2023

AbstractEpidemiological studies have shown that excessive consumption of meat may cause memory loss and cognitive decline, but the underlying mechanism is unknown. Here, a high‐chicken‐protein diet but not a high‐pork diet was found to have a markedly negative impact on the enteric nervous system and hippocampal function. Higher serine, glutamate, and proline levels in the high‐chicken‐protein diet inhibited the absorption capacity of amino acids, reduced the levels of neurotransmitters, and further increased hippocampal β‐secretase levels. Alzheimer's disease mouse model and cell studies confirmed that high‐chicken diet‐induced changes in the intestinal function further resulted in metabolic disorders with a reduction in L‐serine and niacinamide in serum, accumulation of hippocampal β‐amyloid, and eventually aggravated memory and cognitive decline. Our findings highlight the importance of serine, glutamate, and proline as systemic mediators of diet–gut–brain axis homeostasis against memory and cognitive dysfunctions associated with excessive intake of chicken.
Characterization and in vitro assessment of probiotic potential of Lactiplantibacillus plantarum BXM2 from fermented honey passion fruit beverage
Authors: Guan Xuefang , Zhao Dazhou , Yang Yijun , Huang Junyang , Lin Bin , Zheng Yafeng , Wang Qi 
Published: April 2023

AbstractA potential probiotic strain BXM2 was isolated from naturally fermented honey passion fruit beverage, and identified as Lactiplantibacillus plantarum using 16S rDNA sequence analysis, rpoA gene sequence analysis combined with API bacterial identification method. BXM2 was evaluated for its probiotic and technological properties, such as growth efficiency, gastrointestinal tolerance, antibacterial activity and antibiotic resistance. The results showed that the optimum growth efficiency of BXM2 was achieved under the fermentation temperature ranged from 30°C to 37°C. The initial content of BXM2 (8.50 log CFU/mL) was decreased to 7.53 log CFU/mL after 3 h treatment in simulated gastric fluid (pH = 3.0) and 8.12 log CFU/mL after 6 h treatment in simulated intestinal fluid (pH = 8.0) (p < .05). BXM2 showed active antibacterial activity against oral pathogens (Streptococcus mutans, Prevotella intermedia) and foodborne pathogens (Escherichia coli, Staphylococcus aureus, Shigella sonnei, Salmonella Typhimurium, Proteus mirabilis) with average diameters of inhibition zones ranging from 11.00 to 21.67 mm. Autoaggregation rate of BXM2 was 55.41% and coaggregation rates with the tested pathogens ranged from 34.05% to 86.42%. The antibiotic resistance test showed that BXM2 was safe and sensitive to most of the antibiotics. This study provides valuable information for future investigation and industrial application of this selected strain BXM2.
Valorization and food applications of okara (soybean residue): A concurrent review
Authors: Asghar Aasma , Afzaal Muhammad , Saeed Farhan , Ahmed Aftab , Ateeq Huda , Shah Yasir Abbas , Islam Fakhar , Hussain Muzzamal , Akram Noor , Shah Mohd Asif 
Published: April 2023

AbstractAgriculture waste is rising continuously across the globe due to enormous industrial, food processing, and household activities. Proper valorization of this waste could be a promising source of various essential bioactive and functional ingredients. Okara is a major residue produced as result of soybean processing and has a rich nutritional profile. The nutritional profile of okara is affected by the processing conditions, variety, pre‐treatment, post‐production treatments, and processing techniques. Owing to the high fibers, lipids, proteins, and bioactive components, it is being used as an essential industrial ingredient in various food processing industries. The prebiotic potential and nutritional profile can be increased by various techniques, that is, enzymatic, chemical, biotransformation, high‐pressure microfludization, and fermentation. The prebiotic potential of okara makes it suitable as a therapeutic agent to prevent a variety of metabolic disorders such as diabetes, obesity, hypercholesterolemia, and hyperlipidemia. The current review highlights the structural, nutritional, functional, therapeutic, and industrial applications of okara.
Azido‐Functionalized Fullerenes, Perylenediimide, Perylene, and Tetraphenylethylene as Crosslinkers for Applications in Materials Science
Authors: Villegas Carmen , Diacon Aurel , Gorisse Thérèse , Derue Lionel , Freuze Ingrid , Allain Magali , Awada Hussein , Dautel Olivier , Wantz Guillaume , Hudhomme Piétrick 
Published: April 2023

AbstractThis study presents the synthesis and characterization of novel azido molecules with demonstrated crosslinking ability when used as additives in polymer/fullerene organic solar cells. These compounds derived from fullerenes C60 and C70, or dyes from perylenediimide, perylene and tetraphenylethylene frameworks, bearing a different number of azido groups, are of particular interest to stabilize and increase the thermal stability of the device morphology. In particular, the electro and photoactive dye derivatives allow the introduction of additional functionality with the possibility of extending the absorption domain of the photoactive layer. In addition, and more broadly, such azido crosslinkers could find applications in the field of optoelectronic devices as a simple and cheap strategy to improve the performance and long‐term stability of organic solar cells, perovskites solar cells, or organic light‐emitting diodes.