bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal and neonatal outcomes of women diagnosed with Placenta Accreta Spectrum Disorder managed by a standardized Multidisciplinary Team
Authors: Vettorazzi Janete , Farenzena Luisa Penso , Perez Amanda Vilaverde , Reis Martina Amalia Jorge dos , Teichmann Pedro do Valle , Garcia Tiago Selbach , Salazar Cristiano Caetano , Scaffaro Leandro Armani , Ghezzi Caroline Lorenzoni Almeida , Arlindo Ellen Machado , Vettori Daniela Vanessa , Valerio Edimárlei Gonsales 
Published: August 2023

Abstract
Purpose
Placenta accreta spectrum disorder (PAS) is a pathological condition in which placenta abnormally adheres to or invades the myometrium. PAS has a high risk of complications, especially peripartum bleeding, which can be associated with several maternal and neonatal adverse outcomes. Our goal is to determine maternal and fetal outcomes in cases of PAS managed by a multidisciplinary team (MDT).
Methods
This is a retrospective cohort study that included all cases of PAS managed by a MDT between January 2016 and December 2022. Maternal and neonatal outcomes were analyzed for each case.
Results
There were 102 cases of PAS managed by a MDT during the study period. Maternal age average was 35.5 years, 75.4% had at least one prior cesarean section and 55.8% had placenta previa. 54.9% were diagnosed with placenta accreta, 20.5% with placenta increta and 24.5% with placenta percreta. Hysterectomy was performed in 55.8% of the cases, and in 87.7% of them placenta was left in situ. Blood products transfusion was necessary in 24.5% of the cases, with a mean number of 2 red blood cells concentrates. Intensive care unit admission rate after surgery was 8.8% and no maternal death occurred.
Conclusions
Although PAS is a condition associated with high morbidity and mortality, this study demonstrates lower rates of maternal complications than reported in literature. PAS management should be based in protocols, and pregnancy interruption should be performed in centers of excellence with an experienced and trained MDT, making it possible to reduce maternal morbidity and mortality.
Robust JPEG Steganography Based on the Robustness Classifier
Authors: Zhang Jimin , Zhao Xianfeng , He Xiaolei 
Published: August 2023

Abstract
The application of image steganography in popular image-sharing social networks requires robustness because the JPEG recompression in social networks changes the DCT coefficients of uploaded images. Currently, most robust steganography algorithms rely on the resistance of embedding to the general JPEG recompression process, while operations in a specific compression channel are usually ignored, which reduces the robustness performance. Besides, the state-of-the-art robust steganography needs to upload the cover image to social networks several times to acquire the robust cover image, which may be insecure in terms of behavior security. In this paper, a robust steganography method based on the softmax outputs of a trained classifier and protocol message embedding is proposed. In the proposed method, a deep learning-based robustness classifier is trained to model the specific process of the JPEG recompression channel. The prediction result of the classifier is used to select the robust DCT blocks to form the embedding domain. The selection information is embedded as the protocol messages into the middle-frequency coefficients of DCT blocks. To further improve the recovery possibility of the protocol message, a robustness enhancement method that decreases the predicted non-robust possibility of the robustness classifier by modifying low-frequency coefficients of DCT blocks is proposed. The experimental results show that the proposed method is universal and can be implemented in different JPEG compression channels after finetuning the classifier, and it has better robustness performance compared with state-of-the-art robust steganography and does not have the disadvantage in terms of behavior security, and it has better security performance compared with the state-of-the-art method when embedding large-sized secret messages.
The effect of the lowest heat stress limit conditions on psychomotor fatigue threshold in soccer players
Authors: Konefał Marek , Błażejczyk Krzysztof , Chmura Jan , Żmijewski Piotr , Różański Paweł , Chmura Paweł 
Published: August 2023

Abstract
The study aimed to examine relationships between psychomotor fatigue threshold and the lowest heat stress limit (HSL) during incremental exercise, simulated in an environmental test chamber. Twenty-four soccer players performed a graded treadmill running exercise test. Directly before the test and during the break after each load, blood was collected to determine lactate concentration (LA) and serotonin concentration (SER). The heart rate (HR), pulmonary ventilation (Ve) and oxygen uptake (VO2) were recorded and the psychomotor test was performed. The levels of the tested parameters were determined at four measurement points: (1) at rest, (2) at the lactate threshold (TLA), (3) at the threshold of psychomotor fatigue (TPF), (4) at maximum intensity. Percentage differences between maximum intensity (100%) and the values of the tested parameters recorded at the TLA and TPF were also calculated. The tests were carried out in a climatic chamber at an ambient temperature of 28.5°C, relative air humidity of 58.7%. and wind speed of 2 m·s− 1. It was confirmed that the TPF, which reflects the highest efficiency of the central nervous system, occurs at a higher running speed than the TLA. For practical application, it was found that at the HSL, the TPF occurs at: 84% of maximum running speed, 52% of maximum LA concentration, 93% SERmax, 91% HRmax, 73% VEmax, 84% VO2max. The findings may facilitate the understanding of the physiological and psychomotor reactions at the borderline between some and great thermal discomfort (on the humidex scale). This will enable coaches and coaching staff to optimize training sessions in more challenging environments.
Applied anatomy of female pelvic plexus for nerve-sparing radical hysterectomy（NSRH）
Authors: Ye Fan , Su Hongyu , Xiong Hang , Luo Wenxin , Huang ZiHeng , Chen Guoqing , Zhou Hongying 
Published: August 2023

Abstract
Background
Nerve-preserving radical hysterectomy(NSRH)has the advantage of reducing postoperative complications and improving postoperative quality of life. The separation and protection of the pelvic plexus in NSRH is extremely important and challenging.
Methods
24 female cadaveric hemipelvis were dissected. Morphologic patterns and compositions of pelvic plexus as well as relationship of pelvic plexus to the surrounding structures were observed and documented.
Results
Two patterns of superior hypogastric plexus were observed, including fenestrated and cord-like shape. The origin of bilateral hypogastric nerves were inferiorly to upper margin of promontory about 1.6 ± 0.1cm and parallel to the ureter in front of the sacrum. Pelvic splanchnic nerves(PSN)from the second sacral nerve, the third sacral nerve and the forth sacral nerve were observed combing with the hypogastric nerves within the lateral rectal ligament. The sacral sympathetic trunk can be identified anteriorly or medially to the anterior sacral foramen. We identified the boundaries of pelvic plexus as following: the upper margin is formed by the PSNs from the third sacral nerve, posterior margin by inferior rectal artery, and anteriorly by vesical venous plexus. The uterine branches from pelvic plexus were observed accompanying with uterine artery, while other branches were inferiorly to the artery. The PSNs were located beneath the deep uterine veins within the cardinal ligament. The upper margin of pelvic plexus was observed directly approach to urinary bladder within the vesicouterine ligament as a single trunk accompanying with ureter, between the middle and inferior vesical veins.
Conclusions
Our study clarified the intricate arrangement, distribution and relationship of female pelvic plexus and the related structures to provide reference index for NSRH application. The innervation patterns of bladder and uterine were clarified, and by tracing these visceral branches of pelvic plexus, we suggest several new important land markers for NSRH.
Perceptions of paramedic educators on assessments used in the first year of a paramedic programme: A qualitative exploration
Authors: Knox Shane , Brand Charles , Sweeney Catherine 
Published: August 2023

Abstract
Background
In Ireland, there are currently three educational institutions (recognised institutions- RIs) providing paramedic programmes, accredited by the regulator, the Pre-Hospital Emergency Care Council (PHECC). Each RI assesses their students in-house, and in order to acquire a licence to practice, students must also pass summative assessments provided by PHECC. These assessments comprise multiple choice questions, short answer questions and skills assessments. The objective of this study was to explore the perceptions and experiences of paramedic educators of assessments used within their institution and by the regulator to provide insights that could inform the future design of paramedic assessments.
Methods
A qualitative study with an interpretivist approach and purposive sampling strategy was performed. Semi-structured interviews were conducted with educators from one RI, across their three sites. Data were analysed using an inductive approach to thematic analysis.
Results
Four major themes were identified in the data: improving assessments by enhancing authenticity, modifying the current process of assessment, aligning the PHECC and RI examinations and opportunities to use assessment as learning.
Conclusions
This study identifies perceived deficits and opportunities in the assessments currently used for paramedic students and ways in which these assessments could be improved. While participants were relatively content with their own RI assessments, they identified ways to improve both the RI and PHECC assessments. Modifying some of the current methods could be a useful first step. In particular, assessments used by PHECC could be improved by reflecting ‘real-world’ practice. The inclusion of additional assessment methods by PHECC, a continuous assessment process or devolvement of the entire assessment suite, to the RI/University has the potential to enhance assessments, particularly summative assessments, for paramedic students.
Phylogeography and genetic structure of Papever bracteatum populations in Iran based on genotyping-by-sequencing (GBS)
Authors: Rahmati Razieh , Nemati Zahra , Naghavi Mohammad Reza , Pfanzelt Simon , Rahimi Amir , Kanzagh Ali Ghaderi , Blattner Frank R. 
Published: August 2023

Abstract

Papaver bracteatum, known for its high thebaine content and absence of morphine, has emerged as a promising alternative to opium poppy for codeine production. In this study, our objective was to create a diverse panel representing the natural variation of this species in Iran. To achieve this, we employed genotyping-by-sequencing (GBS) to obtain genome-wide distributed single-nucleotide polymorphisms (SNPs) for phylogeographic analysis, population structure assessment, and evaluation of genetic diversity within P. bracteatum populations. A total of 244 P. bracteatum individuals from 13 distinct populations formed seven genetic groups, along with one highly admixed population. We observed a split between the populations inhabiting the Alborz and Zagros Mountain systems. In between these mountain ranges the population of Kachal Mangan exhibited a high degree of genetic admixture. Our results suggest that habitat fragmentation, climate change, limited seed dispersal, and human pressure on the species’ habitats are potential factors contributing to the genetic isolation of P. bracteatum populations. Our findings underscore the urgency of implementing conservation measures to safeguard the wild populations as important genetic resources for future breeding approaches in this medicinally important species.
Interspecific recognition based on cuticular hydrocarbons mediates reproduction control in aphids
Authors: Li Yang , Parven Nousheen , Akimoto Shin-ichi 
Published: August 2023

Abstract
The preset study tested whether an aphid species can control its reproduction by recognizing the presence and density of a rival species. Acyrthosiphon pisum and Megoura crassicauda often coexist on the same leguminous plant. We established clonal colonies from each species and mixed colonies with one A. pisum and one M. crassicauda adult. There were no significant differences in the population growth patterns of the two species at 20 °C. However, mixed colonies increased faster and attained larger colony sizes than the clonal colonies. Thus, positive interspecific interactions were confirmed. A mixed colony was dominated by the members of a clone that produced a greater number of newborns in the initial stage, irrespective of the species. Thus, we confirmed the priority effect in the interspecific competition. To simulate the priority effect, 15 glass beads coated with the hexane extract of M. crassicauda aphids were attached to a cut leaf, to which one A. pisum adult was transferred. The presence of the hexane extract of M. crassicauda greatly reduced the reproductive rate of A. pisum adults. We conclude that aphids can control their reproduction by evaluating the relative density of rivals to fellow aphids based on the cuticular hydrocarbons.
Rewritable nano print of ionic liquids utilizing focused ion beam induced film wetting
Authors: Wang Hao , Gu Haohao , Meng Kaixin , Yuan Ruowei , Xiao Siyang , Shan Yuying , Zhu Rui , Deng Yajun , Luo Xiaojin , Li Ruijie , Liu Lei , Chen Xu , Duan Chuanhua , Shi Yuping 
Published: August 2023

Abstract
Manipulating liquid flow over open solid substrate at nanoscale is important for printing, sensing, and energy devices. The predominant methods of liquid maneuvering usually involve complicated surface fabrications, while recent attempts employing external stimuli face difficulties in attaining nanoscale flow control. Here we report a largely unexplored ion beam induced film wetting (IBFW) technology for open surface nanofluidics. Local electrostatic forces, which are generated by the unique charging effect of Helium focused ion beam (HFIB), induce precursor film of ionic liquids and the disjoining pressure propels and stabilizes the nanofilm with desired patterns. The IBFW technique eliminates the complicated surface fabrication procedures to achieve nanoscale flow control, and enables the manufacturing of complex liquid circuit in a controllable and rewritable manner.
The progression of hepatocyte pyroptosis exacerbates radiation-induced liver disease via the gasdermin D/signal transducer and activator of transcription 5a/CXCL1 axis
Authors: Peng Zhenwei , Dong aoran , Wei Guangyan , Liang Zhou , Di Yuqin , Tang Yunhao , Ling Yunyan , Li Shuping , Chen Yong , Zhou Yi , Wang Xiongjun 
Published: August 2023

Abstract
Radiation-induced liver disease (RILD) severely impairs the outcome of patients exposed to irradiation (IR); however, the underlying mechanism is largely unknown. The N-terminus of gasdermin D (GSDMD-N) is mainly involved in driving the progression of pyroptosis, and its expression has been reported to be induced by IR in the gut and bone marrow, but its role in RILD remains unknown. By collecting liver samples from RILD patients and mice, we uncovered GSDMD-FL/N were significantly upregulated and positively correlated with RILD severity. Hepatocytes are found to be critical pyroptotic cells in RILD by combining single-cell RNA sequencing (scRNA-seq), immunofluorescence and fluorescence-activated cell sorting (FACS) analysis. Functional analysis and mechanistic studies were performed using hepatocyte-specific Gsdmd knockout (Gsdmd∆Hep) mice and cell models and scRNA-seq analysis. Mechanistically, GSDMD was indispensable for triggering hepatocyte pyroptosis and initiating the activation of transcription factor stat5a, which subsequently facilitated the expression of CXCL1. As a pore-forming protein, increased GSDMD-N also mediated the secretion of CXCL1, which further recruited neutrophil into liver to accelerate the severity of RILD. We also discovered that pharmacological targeting GSDMD and its downstream CXCL1 effectively attenuated the progression of RILD. RILD progression requires increased GSDMD-FL/N in hepatocytes, causing pyroptosis and stat5a activation. Afterwards, driving CXCL1 express and release to recruit neutrophils into liver. Together, our study demonstrates that GSDMD as therapeutic targets to improve RILD.
Think global act local: the dependency of global lithium-ion battery emissions on production location and material sources
Authors: Kallitsis Evangelos , Lindsay Jordan , Chordia Mudit , Wu Billy , Offer Gregory , Edge Jacqueline 
Published: August 2023

Abstract
The pursuit of low-carbon transport has significantly increased demand for lithium-ion batteries. However, the rapid increase in battery manufacturing, without adequate consideration of the carbon emissions associated with their production and material demands, poses the threat of shifting the bulk of emissions upstream. In this article, a life cycle assessment (LCA)-inspired model is developed to account for battery material and energy demand contributions for the cradle-to-gate carbon footprint of lithium-ion batteries across the world’s dominant battery manufacturing locations. Analysis of published LCA data reveals a significant level of uncertainty associated with the carbon emissions of key battery materials, with the 95 % confidence interval for nickel and cobalt containing chemistries ranging from 40 to 90 kg CO2-eq kWh-1. The gate-to-gate carbon footprint of battery manufacturing is found to vary highly with predicted median values ranging between 0.15 and 94.5 kg CO2-eq kWh-1, depending on production location. Leading western-world battery manufacturing locations in the US and Europe, such as Kentucky and Poland are found to have comparable carbon emissions to Chinese rivals, even exceeding the carbon emissions of battery manufacturing in some Chinese provinces. Such resolution on material and energy contributions to the carbon footprint of batteries is essential to inform policy- and decision- making in order to minimise the carbon emissions of the battery value chain.
Revolutionizing Oil and Gas Production State Diagnosis with Digital Twin and Deep Learning Fusion Technology
Authors: Ren Shuangshuang , Shen Fei , Li Jun , Zhang Xiangyang , Liu Yuanhong 
Published: August 2023

Abstract
Digital twins have become an effective tool for monitoring and diagnosing the state of oil and gas production processes. However, due to the complexity of production processes, traditional digital twin models may perform poorly. To address these issues, an improved long and short-term memory (LSTM) neural network is introduced to digital twins to provide real-time diagnosis capabilities for the oil and gas production process. First, a digital twin model is constructed based on the physical model of oil and gas production processes to simulate the behavior of the real system. Surface data is then employed to estimate well data, which is subsequently used to train the LSTM neural network. The trained neural network is used to analyze real-time data collected from sensors installed in the physical system and update the digital twin model accordingly. By comparing the behavior of the real system and the digital twin model, any deviation can be identified, and the state of oil and gas production can be diagnosed. Additionally, the improved neural network optimizes the performance of the digital twin model by reducing the impact of complex production processes and improving the accuracy and efficiency of diagnosis. In the same block or well during different periods, the long-short memory network is used to predict the next state of oil and gas production based on real-time data, enabling the process to realize the deep fusion of physical layer and information layer data, and attain self-perception and self-prediction abilities. The results show that the proposed method effectively monitors and predicts the operational state of oil and gas production, providing critical data for improving production efficiency. Digital twins and deep learning technology can improve the intelligence of the oil and gas production process and provide theoretical support for the development of intelligent oil and gas fields in the future.
Study on the pathogenesis of hSOD1 mice by SHH through FAK/ERK pathway
Authors: Qi Yan , Xu Jin , Wang Ying , Gao Yi , Sun Zhitang , Deng Zhanjin , Shao Yixin , Li Pengcui , Nieland John Dirk Vestergaard 
Published: August 2023

AbstractAmyotrophic lateral sclerosis (ALS) is an irreversible neurodegenerative disease that involves the spinal cord and then causes reduced function of the extremities, and eventually often involves respiratory muscles and leads to death, 10% of cases are related to family inheritance, and the most frequent gene mutation is SOD1. In hSOD1G93A transgenic mice using Western Blot and immunohistochemistry techniques we found that the expression of SHH, FAK, ERK, p-FAK, and p-ERK was progressively decreased in the spinal cord tissue of hSOD1 mice over time. By stimulating SHH with an agonist, the SHH, FAK, ERK, p-FAK, p-ERK protein levels increased, while SHH, FAK, p-FAK protein decreased significantly by inhibiting SHH compared to the hSOD1 control group. The HE staining results of mouse gastrocnemius muscle showed that the agonist group had an increased muscle morphology and more muscle fibers than the hSOD1 control group, while the inhibitor group had an atrophied muscle morphology and fewer muscle fibers than the hSOD1 control group. Our experiments confirmed that SHH, FAK and ERK may have an upstream and downstream relationship in the spinal cord tissue of hSOD1 mice, and that PUR can activate SHH protein and enhance the function of FAK/ERK. SHH is suggested to play a protective role in the muscle tissue of hSOD1 mice through the FAK/ERK pathway.
Climate change causes an evolutionary change in seasonal timing of a long-distance migrant bird
Authors: Both Christiaan , Nicolaus Marion , Ubels Richard , Ouwehand Janne , Tomotani Barbara , Visser Marcel 
Published: August 2023

Abstract
Climate change alters ecological interactions, and, because observed phenotypic responses are often insufficient1,2, evolutionary responses are required3. However, these have rarely been reported, and species seem to either adapt through plasticity4 or suffer population declines5. Earlier work suggested that especially long-distance migrants cannot adjust their complex annual cycle by phenotypic plasticity, because they lack predictable cues at their distant wintering grounds6,7. Here we show that the ongoing advance in spring arrival and laying dates in a pied flycatcher population results from cross-generational processes. Using a 51-year time-series we show that during the 25-year period with a strong increase in spring temperature, the population advance in laying dates could only be partly explained by phenotypic plasticity, and primarily resulted from an evolutionary change. Spring arrival from the African wintering grounds advanced simultaneously, and this was unrelated to conditions at the breeding grounds. Individual plasticity of laying date to temperature resulted from shortening the interval between arrival date and laying date, whereas the cross-generational effect was caused by advancing the arrival date. This observed evolution of migration timing can only proceed with ongoing climate change if conditions at the wintering grounds or during migration will not constrain earlier arrival in spring.