bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nurses’ perceptions about bereavement care in critical care units: A qualitative study
Authors: Ong Keh Kiong , Yong Ying Bing , Kowitlawakul Yanika 
Published: August 2023

AbstractAimTo explore critical care nurses’ perceptions of bereavement nursing care in critical care settings at a tertiary hospital in Singapore.BackgroundGrief and bereavement are stressful life experiences associated with significant health problems. Critical care nurses play important roles in supporting bereaved family members, and their self‐competence affects the quality of the care they deliver. Exploring critical care nurses’ perceptions of bereavement nursing care is thus essential.MethodsAn exploratory descriptive qualitative study design was adopted. A total of 16 nurses were recruited. One‐on‐one interviews were conducted using a semi‐structured interview guide and were audio‐recorded. The data collected were analysed using thematic analysis. This study was reported according to the Consolidated Criteria for Reporting Qualitative Research checklist.FindingsFive themes surfaced in the study, namely, family responses, holistic care, psychological impact, self‐competence and organisational dynamics.ConclusionThis study highlighted the key roles of critical care nurses in providing bereavement care, how their self‐competence impacts care delivery and the significant impacts of organisational policies on their capacity to provide care.Implications for nursing and nursing policyNursing administrators should provide enhanced organisational support to critical care nurses who provide bereavement nursing care, and implement training work plans to ensure nurses are adequately prepared to provide culturally appropriate care. Strategies should be introduced to reduce administrative burden, expand the role of critical care nurses in providing bereavement nursing care, and establish and enlist role models as drivers of bereavement nursing care.
Effects of accrual constraints in cooperative advertising programs for distribution channels with one manufacturer and two retailers
Authors: Liu Bin , Xie Jinxing , Zhong Feimin 
Published: August 2023

AbstractThis paper considers a distribution channel with one manufacturer and two independent retailers and investigates how the accrual rate in a cooperative advertising program affects channel members’ performances. When the two retailers’ profit margins are the same, the accrual rate cannot benefit the manufacturer, which coincides with previous studies. However, if the retailers hold different profit margins, the accrual rate may benefit the manufacturer, which is never reported in existing literature. Specifically, when the market faced by the higher‐profit‐margin retailer exhibits a lower advertising efficacy, the manufacturer always prefers using an accrual rate if his profit margin is sufficiently high. Numerical simulations show that even when the manufacturer's profit margin is low, using an accrual rate may also lead to a Pareto improvement for the channel members. The main findings can be extended to the scenario with more than two retailers or with endogenously decided prices of channel members.
The effect of silicon fertilizers on agronomic performance of bread wheat under drought stress and non‐stress conditions
Authors: Christian Marylyn M. , Shimelis Hussein , Laing Mark D. , Tsilo Toi J. 
Published: August 2023

AbstractDrought is one of the major constraints of wheat production, especially in rainfed wheat production systems. The objective of this study was to evaluate the effects of different silicon fertilizer formulations on the agronomic performance of diverse wheat genotypes under drought‐stressed conditions. Twenty wheat genotypes were evaluated in field and greenhouse environments under non‐stressed and drought‐stressed and two silicon fertilizer formulations (granular and liquid potassium silicate) and untreated control. The four‐way interaction involving genotype, environment, water regime and silicon formulation had a significant effect (p < .05) for aboveground biomass, productive spike number, hundred seed weight and grain yield. Granular silicon application was the most effective treatment both under non‐stressed and drought‐stressed conditions compared to the liquid and control treatments. Under field and drought conditions, the highest yielding genotype was MC18, which exhibited a mean grain yield of 4.17 t ha−1 with granular silicon, 2.56 t ha−1 with liquid silicon and 2.18 t ha−1 without silicon. The yield of genotype MC18 improved by 91.3% using granular silicon under drought‐stressed and by 44.6% under non‐stressed conditions compared with the untreated control. Granular silicon positively affected the drought stress tolerance indices compared to the liquid silicon and untreated control. The principal component biplot analysis revealed that liquid and granular silicon positively impact yield response for all test genotypes under drought‐stressed and non‐stressed conditions compared with the control. Silicon application reduced genotype variation for agronomic traits and enhanced agronomic trait relationships under drought‐stressed conditions. Drought stress tolerance indices are influenced by silicon application. The effect of silicon has a direct and indirect effect on yield and yield components. Silicon fertilization can be considered as a mitigation measure to cope with the adverse effect of drought stress on wheat.
Registered nurses' cultural orientation competence for culturally and linguistically diverse nurses in the hospital setting: A cross‐sectional study
Authors: Paatela Satu , Pohjamies Netta , Kanste Outi , Haapa Toni , Oikarainen Ashlee , Kääriäinen Maria , Mikkonen Kristina 
Published: August 2023

AbstractAimsTo explore registered nurses' cultural orientation competence profiles for providing culturally and linguistically diverse (CALD) nurses with orientation in the hospital setting, and to identify which factors are associated with cultural orientation competence profiles.DesignA descriptive, explorative cross‐sectional study.MethodsData were collected from December 2020 to January 2021 using the Preceptors' Orientation Competence Instrument (POCI) and Preceptors' Cultural Orientation Competence Instrument (POCCI). A total of 844 registered nurses from one university hospital district in Finland participated, reflecting a response rate of 10%. A K‐means cluster algorithm was employed to identify different cultural orientation competence profiles.ResultsThe cluster analysis identified three cultural orientation competence profiles (A, B and C). Nurses in Profile A evaluated their cultural orientation competence the highest, with members of profiles B and C demonstrating the second highest and lowest, respectively, cultural orientation competence scores. Several factors were associated with cultural orientation competence profiles, namely, orientation education and student mentoring education, support from managers and colleagues, motivation, willingness to act as a preceptor, time to provide orientation, sufficient clinical and theoretical nursing skills and current work title.ConclusionCultural diversity and acceptance of it can be enhanced by building accepting culture towards new incomers and offering continuing education to improve the cultural competence of staff, which can further benefit patient care of CALD patients. Orientation practices can be improved by rewarding staff and building collaborative teamwork culture.Implications for Profession and/or Patient CareOrganizations can strengthen nurses' cultural orientation competence; for example, by providing adequate orientation education and allocating more time to the orientation process.Reporting MethodThe STROBE criteria were used to report the results of the observations critically.Patient or Public ContributionNo patient or public contribution.
Tailored ablation index based on left atrial wall thickness assessed by computed tomography for pulmonary vein isolation in patients with atrial fibrillation
Authors: Lee So‐Ryoung , Park Hyoung‐Seob , Kwon Soonil , Choi Eue‐Keun , Oh Seil 
Published: August 2023

AbstractIntroductionAlthough left atrial wall thickness (LAWT) is known to be varied, a fixed target Ablation Index (AI) based pulmonary vein isolation (PVI) has been suggested in catheter ablation for atrial fibrillation (AF). We aimed to evaluate the efficacy and safety of PVI applying tailored AI based on LAWT assessed by cardiac computed tomography (CT).MethodsThe thick segment was defined as the segment including ≥LAWT grade 3 (≥1.5 mm). The fixed AI strategy was defined as AI targets were 450 on the anterior/roof segments and 350 on the posterior/inferior/carina segments regardless of LAWT. The tailored AI strategy consisted of AI increasing the targets to 500 on the anterior/roof segments and to 400 on the posterior/inferior/carina segments when ablating the thick segment. After PVI, acute pulmonary vein (PV) reconnection, defined by the composite of residual potential and early reconnection, was evaluated.ResultsA total of 156 patients (paroxysmal AF 72%) were consecutively included (86 for the fixed AI group and 70 for the tailored AI group). The tailored AI group showed a significantly lower rate of segments with acute PV reconnection than the fixed AI group (8% vs. 5%, p = .007). The tailored AI group showed a trend for shorter ablation time for PVI. One‐year AF/atrial tachycardia free survival rate was similar in two groups (87.2% in the fixed AI group and 90.0% in the tailored AI group, p = .606).ConclusionApplying tailored AI based on the LAWT was a feasible and effective strategy to reduce acute PV reconnection after PVI.
Efficacy of 3D‐multidetector computed tomography and fluoroscopy fusion for percutaneous left atrial appendage occlusion procedures
Authors: Carneiro Herman A. , Dallan Luis A. P. , Yoon Sung‐Han , Arora Shilpkumar , Knezevich Juliana , Wass Sojin , Lobo Tabitha , Arruda Mauricio , Rashid Imran , Filby Steven J. 
Published: August 2023

AbstractIntroductionWe studied the impact of the use of three‐dimensional multidetector computed tomography (3D‐MDCT) and fluoroscopy fusion on percutaneous left atrial appendage occlusion (LAAO) procedures in relation to procedure time, contrast volume, fluoroscopy time, and total radiation.MethodsThis was a single‐center, prospective, single‐blinded, randomized control trial. Patients meeting criteria for LAAO were randomized to undergo LAAO with the WATCHMAN FLXTMdevice with and without 3D‐MDCT‐fluoroscopy fusion guidance using a prespecified protocol using computed tomography angiography for WATCHMAN FLXTMsizing, moderate sedation, and intracardiac echocardiography for procedural guidance.ResultsOverall, 59 participants were randomly assigned to the fusion (n = 33) or no fusion (n = 26) groups. The median (interquartile range) age was 79 (75–83) years, 24 (41%) were female, and 55 (93%) were Caucasian. The median CHA2DS2VASc and HASBLED scores were 5 (4–6) and 3 (3–4), respectively. At the time of the study, 51 (53%) patients were on a direct acting oral anticoagulant. There were no significant differences between the fusion and no fusion groups in procedure time (52.4 ± 15.4 vs. 56.8 ± 19.5 min,p = .36), mean contrast volume used (33.8 ± 12.0 vs. 29.6 ± 11.5 mls,p = .19), mean fluoroscopy time (31.3 ± 9.9 vs. 28.9 ± 8.7 min,p = .32), mean radiation dose (1177 ± 969 vs. 1091 ± 692 mGy,p = .70), and radiation dose product curve (23.9 ± 20.5 vs. 35.0 ± 49.1 Gy cm2,p = .29). There was no periprosthetic leak in the two groups in the immediate 1‐month postprocedure follow‐up periods.ConclusionsThere was no significant difference with and without 3D‐MDCT‐fluoroscopy fusion in procedure time, contrast volume use, radiation dose, and radiation dose product.
Randomized, multicenter, parallel, open, phase 4 study to compare the efficacy and safety of rosuvastatin/amlodipine polypill versus atorvastatin/amlodipine polypill in hypertension patient with dyslipidemia
Authors: Jung Hae Won , Kim Chang‐Yeon , Hong Seung‐Pyo , Bae Han‐Joon , Choi Ji Yong , Ryu Jae Kean , Lee Jin‐bae , Lee Kyoung‐Hoon , Han Kyoo‐Rok , Yang Dong‐Heon , Park Chang‐Gyu , Yu Gheol‐Woong , Rhee Moo‐Yong , Park Sung‐Ji , Hyon Min‐Su , Shin Joon‐Han , Hong Bum‐Kee , Jin Han‐Young , Lee Sung‐Yun , Seol Sang‐Hoon , Lee Sang‐Rok , Kim Song‐Yi , Lee Kwang‐Je , Cho Eun‐Joo , Nam Chang‐Wook , Park Tae‐Ho , Kim Ung , Kim Kee‐Sik 
Published: August 2023

AbstractThe authors performed this study to investigate the efficacy and safety of a rosuvastatin (RSV)/amlodipine (AML) polypill compared with those of atorvastatin (ATV)/AML polypill. We included 259 patients from 21 institutions in Korea. Patients were randomly assigned to 1 of 3 treatment groups: RSV 10 mg/AML 5 mg, RSV 20 mg/AML 5 mg, or ATV 20 mg /AML 5 mg. The primary endpoint was the efficacy of the RSV 10.20 mg/AML 5 mg via percentage changes in LDL‐C after 8 weeks of treatment, compared with the ATV 20 mg /AML 5 mg. There was a significant difference in the mean percentage change of LDL‐C at 8 weeks between the RSV 10 mg/AML 5 mg and the ATV 20 mg/AML 5 mg (full analysis set [FAS]: −7.08%, 95% CI: −11.79 to −2.38,p = .0034, per‐protocol analysis set [PPS]: −6.97%, 95% CI: −11.76 to −2.19,p = .0046). Also, there was a significant difference in the mean percentage change of LDL‐C at 8 weeks between the RSV 20 mg/AML 5 mg and the ATV 20 mg/AML 5 mg (FAS: −10.13%, 95% CI: −15.41 to −4.84,p = .0002, PPS: −10.96%, 95% CI: −15.98 to −5.93,p < .0001). There was no significant difference in the adverse events rates between RSV 10 mg/AML 5 mg, RSV 20 mg/AML 5 mg, and ATV 20 mg/AML 5 mg. In conclusion, while maintaining safety, RSV 10 mg/AML 5 mg and the RSV 20 mg/AML 5 mg more effectively reduced LDL‐C compared with the ATV 20 mg /AML 5 mg (Clinical trial: NCT03951207).
Visfatin aggravates transverse aortic constriction‐induced cardiac remodelling by enhancing macrophage‐mediated oxidative stress in mice
Authors: Shen Caijie , Fang Renyuan , Wang Jian , Wu Nan , Wang Shuangsuang , Shu Tian , Dai Jiating , Feng Mingjun , Chen Xiaomin 
Published: August 2023

AbstractPrevious studies have reported that visfatin can regulate macrophage polarisation, which has been demonstrated to participate in cardiac remodelling. The aims of this study were to investigate whether visfatin participates in transverse aortic constriction (TAC)‐induced cardiac remodelling by regulating macrophage polarisation. First, TAC surgery and angiotensin II (Ang II) infusion were used to establish a mouse cardiac remodelling model, visfatin expression was measured, and the results showed that TAC surgery or Ang II infusion increased visfatin expression in the serum and heart in mice, and phenylephrine or hydrogen peroxide promoted the release of visfatin from macrophages in vitro. All these effects were dose‐dependently reduced by superoxide dismutase. Second, visfatin was administered to TAC mice to observe the effects of visfatin on cardiac remodelling. We found that visfatin increased the cross‐sectional area of cardiomyocytes, aggravated cardiac fibrosis, exacerbated cardiac dysfunction, further regulated macrophage polarisation and aggravated oxidative stress in TAC mice. Finally, macrophages were depleted in TAC mice to investigate whether macrophages mediate the regulatory effect of visfatin on cardiac remodelling, and the results showed that the aggravating effects of visfatin on oxidative stress and cardiac remodelling were abrogated. Our study suggests that visfatin enhances cardiac remodelling by promoting macrophage polarisation and enhancing oxidative stress. Visfatin may be a potential target for the prevention and treatment of clinical cardiac remodelling.
Subsidiarity Ex Ante and Ex Post: From the Early Warning System to the Court of Justice of the European Union
Authors: Huysmans Martijn , van den Brink Ton , van Gruisen Philippe 
Published: August 2023

AbstractThe subsidiarity principle divides competences between the European Union and its Member States. The Lisbon Treaty suggests a connection between ex ante and ex post subsidiarity review. Ex ante, national parliaments were given a role via the early warning system (EWS). Ex post, legislation is subject to review by the Court of Justice of the European Union (CJEU). More than 10 years after Lisbon, this article is the first to theorize and evaluate whether there is indeed a connection. Our theory predicts a conditional connection. Quantitatively, we provide a two‐way classification of Member States based on their use of the EWS and CJEU subsidiarity cases. Qualitatively, we look back from court cases to the Council stage and analyse the Advocate General's opinions in subsidiarity cases. We find a weak conditional connection. A key explanation appears to be the Court's limited willingness to enforce subsidiarity and hence the limited incentives to go to court.
Sun exposure behaviours as a compromise to paradoxical injunctions: Insight from a worldwide survey
Authors: Passeron Thierry , Lim Henry W. , Goh Chee Leok , Kang Hee Young , Ly Fatimata , Morita Akimichi , Ocampo‐Candiani Jorge , Puig Susana , Schalka Sergio , Liu Wei , Demessant‐Flavigny Anne‐Laure , Le Floc’h Caroline , Kerob Delphine , Dreno Brigitte , Krutmann Jean 
Published: August 2023

AbstractBackgroundBehavioural interventions can improve attitudes towards sun protection but the impact remains inconsistent worldwide.ObjectiveTo assess awareness of and attitudes towards the multiple facets of sun exposure and suggest ways to improve prevention from overexposure to the sun in all geographical zones and multiple skin types.MethodsOnline survey was conducted from 28 September to 18 October 2021. Study population was selected from the Ipsos online Panel (3,540,000 panellists), aged ≥18 years, from 17 countries around the five continents. Demographics, sun‐exposure habits and practices, understanding of risks and information on phototypes were documented and analysed using descriptive statistics.ResultsEighty‐eight per cent of participants knew that sunlight can cause skin health problems (90% phototypes I‐II, 82% phototypes V‐VI, >90% in American and European countries, 72% in Asia and 85% in Africa). Eighty‐five per cent used some form of protection against sunlight, predominantly: Seeking shade (77%), avoiding the midday sun (66%), facial application of sunscreen (60%) and wearing protective clothing (44%). The perception of sunlight itself is positive (‘it gives energy’ for 82%; ‘tanned skin looks attractive’ for 72%), although less in Asian countries and among individuals with dark skin phototypes. Eighty‐three per cent reported having experienced sunburn, mainly in Australia, Canada, USA, Germany, France and Russia, and among individuals with dark skin phototypes. Only 12% systematically/often used all types of protection during exposure to the sun and 23% believed it is safe to go out in the sun with no protection when their skin is already tanned. From 13% (skin phototype I) to 26% (phototype VI) reported not using any form of protection against the sun. Knowledge and habits were significantly superior among people who are accustomed to seeing a dermatologist for a complete skin exam.ConclusionsDermatologists could play a crucial role in relaying novel prevention messages, more finely tailored to specific risks, populations and areas of the world.
Fast, bedside diagnosis of toxic epidermal necrolysis using ex vivo confocal laser scanning microscopy: A retrospective study
Authors: Tonellotto L. , Seremet T. , Vernez M. , Guenova E. , Kuonen F. 
Published: August 2023

AbstractBackgroundToxic epidermal necrolysis (TEN) is a severe life‐threatening drug eruption with rapid evolution. A fast histologic differentiation between TEN and clinically similarly looking staphylococcal scalded skin syndrome is of vital importance for relevant treatment decision. The recently developed ex vivo confocal laser scanning microscopy (CLSM) offers innovative and extremely fast histological visualization of fresh tissue specimens.ObjectiveTo assess the diagnostic efficacy of ex vivo CLSM in comparison with standard histopathology for TEN.MethodsWe performed side‐by‐side comparison of TEN specimens analysed with ex vivo CLSM and haematoxylin and eosin staining. Analysis focused on typical histopathological features of TEN, including epidermal cleavage in the basal layer and confluent epidermal necrosis. We retrospectively assessed the diagnostic performance of ex vivo CLSM for TEN in clinically confirmed cases.ResultsWe report substantial agreement between ex vivo CLSM and classical histology for the detection of subepidermal cleavage and confluent epidermal necrosis. When considering full‐thickness epidermal loss, epidermal cleavage in the basal layer showed the highest diagnostic performance, reaching 87.5% sensitivity and 100% specificity.ConclusionBased on our data, ex vivo CSLM appears as a rapid, resource‐optimizing, and reliable approach for morphological TEN emergency screening on fresh skin samples.
The safety of systemic Janus kinase inhibitors in atopic dermatitis: A systematic review and meta‐analysis of randomized controlled trials
Authors: Yoon Sanghyuk , Kim Kihun , Shin Kihyuk , Kim Hoon‐Soo , Kim Byungsoo , Kim Moon‐Bum , Ko Hyun‐Chang , Kim Yun Hak 
Published: August 2023

AbstractJanus kinase (JAK) inhibitors have been recently approved by the FDA and are widely used in the treatment of patients with atopic dermatitis. However, a comprehensive safety profile of JAK inhibitors in patients with atopic dermatitis has not been analysed. This study aimed to establish clinical evidence for the safety of systemic JAK inhibitors in patients with atopic dermatitis. Medline, Embase, Clinicaltrials.gov, Cochrane Central Register of Controlled Trials (CENTRAL) and International Clinical Trials Registry Platform (ICTRP) were considered for search databases. Randomized controlled trials reporting the adverse events of systemic therapy in patients with atopic dermatitis were included. The risk of 11 adverse events was compared between the JAK inhibitors and placebo groups. Fourteen randomized controlled trials were analysed published between 2019 and 2022. The JAK inhibitors included in the analysis were abrocitinib (10, 30, 100 and 200 mg), baricitinib (1, 2 and 4 mg) and upadacitinib (7.5, 15 and 30 mg). The risk of herpes zoster, headache, acne, elevated blood creatinine phosphokinase and nausea was significantly increased, but the risk of serious infection, non‐melanoma skin cancer (NMSC), malignancies other than NMSC, major adverse cardiovascular event, venous thromboembolism and nasopharyngitis was not increased. This study provides comprehensive clinical evidence on the risk of various adverse events in patients with atopic dermatitis. However, since the follow‐up periods of the studies analysed in this review were mostly limited to 16 weeks or less, it is recommended that comprehensive long‐term observational studies be conducted to determine any potential adverse events associated with major cardiovascular events or malignancies, which typically have prolonged courses.