bluuebunny/crossref_metadata_2025_split huggingface dataset:
GOgetter: A pipeline for summarizing and visualizing GO slim annotations for plant genetic data
Authors: Sessa Emily B. , Masalia Rishi R. , Arrigo Nils , Barker Michael S. , Pelosi Jessie A. 
Published: August 2023

AbstractPremiseThe functional annotation of genes is a crucial component of genomic analyses. A common way to summarize functional annotations is with hierarchical gene ontologies, such as the Gene Ontology (GO) Resource. GO includes information about the cellular location, molecular function(s), and products/processes that genes produce or are involved in. For a set of genes, summarizing GO annotations using pre‐defined, higher‐order terms (GO slims) is often desirable in order to characterize the overall function of the data set, and it is impractical to do this manually.Methods and ResultsThe GOgetter pipeline consists of bash and Python scripts. From an input FASTA file of nucleotide gene sequences, it outputs text and image files that list (1) the best hit for each input gene in a set of reference gene models, (2) all GO terms and annotations associated with those hits, and (3) a summary and visualization of GO slim categories for the data set. These output files can be queried further and analyzed statistically, depending on the downstream need(s).ConclusionsGO annotations are a widely used “universal language” for describing gene functions and products. GOgetter is a fast and easy‐to‐implement pipeline for obtaining, summarizing, and visualizing GO slim categories associated with a set of genes.
Short Versus Long Range Exchange Interactions in Twisted Bilayer Graphene
Authors: Jimeno‐Pozo Alejandro , Goodwin Zachary A. H. , Pantaleón Pierre A. , Vitale Valerio , Klebl Lennart , Kennes Dante M. , Mostofi Arash A. , Lischner Johannes , Guinea Francisco 
Published: August 2023

AbstractThis study discusses the effect of long‐range interactions within the self‐consistent Hartree‐Fock (HF) approximation in comparison to short‐range atomic Hubbard interactions on the band structure of twisted bilayer graphene (TBG) at charge neutrality for various twist angles. Starting from atomistic calculations, it determines the quasi‐particle band structure of TBG with Hubbard interactions for three magnetic orderings: modulated anti‐ferromagnetic (MAFM), (NAFM) and hexagonal anti‐ferromagnetic (HAFM). Then, it develops an approach to incorporate these magnetic orderings along with the HF potential in the continuum approximation. Away from the magic angle, it observes a drastic effect of the magnetic order on the band structure of TBG compared to the influence of the HF potential. Near the magic angle, the HF potential plays a major role in the band structure, with HAFM and MAFM being secondary effects, but NAFM appears to still significantly distort the electronic structure at the magic angle. These findings suggest that the spin‐valley degenerate broken symmetry state often found in HF calculations of charge neutral TBG near the magic angle should favor magnetic order, since the atomistic Hubbard interaction will break this symmetry in favor of spin polarization.
Conservation‐relevant reproductive parameters from long‐term tagging of two globally important sea turtle nesting aggregations in Central Africa
Authors: Casale Paolo , Abitsi Gaspard , Agamboue Pierre Didier , Augowet Eric , Bayet Jean Pierre , Billes Alexis , Bitsindou Abdon , Collins Tim , Doherty Phil D. , Faure François Edgard , Fretey Jacques , du Plessis Philippe , Gibudi Alain , Godley Brendan J. , Kema Kema Judicaël Regis , Koumba Mabert Brice D. , Lamou Boussamba François , Maganga Pierre Brice , Manfoumbi Jean Churley , Ondo Ndong Bienvenue , Metcalfe Kristian , Minton Gianna , Mounguengui Gil Avery , Ngouessono Solange , Nzegoue Jacob , Kouerey Oliwina Carmen Karen , Parnell Richard J. , Ricois Sandrine , Roumet Dominique , Sounguet Guy‐Philippe , Tilley Dominic , van Leeuwe Hilde , Verhage Bas , White Lee , Witt Matthew J. , Viljoen Wynand , Formia Angela 
Published: August 2023

Abstract

Assessing abundance and monitoring ecology and population trends are of critical importance for animal species of conservation concern. For sea turtles, annual nest counts represent the most common method of estimating population size. However, to develop a better understanding of population trends, these data need to be complemented by other reproductive parameters, which are lacking for many nesting populations across central Africa.
To this end, an intensive capture–mark–recapture programme was conducted spanning 21 years (1997–2018) in the most important nesting sites on the Atlantic coast of central Africa (Gabon and Congo) for leatherback (Dermochelys coriacea) and olive ridley (Lepidochelys olivacea) sea turtles.
A total of 18,105 encounters of 14,109 D. coriacea individuals and 2678 encounters of 2427 L. olivacea individuals were recorded. Biological and technical parameters such as clutch frequency, inter‐nesting interval, remigration interval, annual survival rate, somatic growth, size trends, tag loss and number of annual nesting females were estimated through a variety of methods and models.
The study detected a decline in body size and low survival probability (not due to tag loss) in both species but no clear decline in estimated annual number of nesting females. High fidelity to nesting sites (<30 km for both species) implies that the current conservation strategy, protecting the main nesting areas, could be effective.
We recommend that local conservation managers promote: (i) continued monitoring of the nesting activity of the two species through capture–mark–recapture programmes; (ii) continued nest counts at long‐term monitoring sites, which may also detect possible spatial shifts; and (iii) strengthening of cross‐border cooperation between Gabon and Republic of the Congo given the observed connectivity between nesting sites of the two countries.
A Novel High‐Performance Electrolyte for Extreme Fast Charging in Pilot Scale Lithium‐Ion Pouch Cells
Authors: Du Zhijia , Yang Zhenzhen , Tao Runming , Shipitsyn Vadim , Wu Xianyang , Robertson David C. , Livingston Kelsey M. , Hagler Shae , Kwon James , Ma Lin , Bloom Ira D. , Ingram Brian J. 
Published: August 2023

AbstractRealizing extreme fast charging (XFC) in lithium‐ion batteries for electric vehicles is still challenging due to the insufficient lithium‐ion transport kinetics, especially in the electrolyte. Herein, a novel high‐performance electrolyte (HPE) consisting of lithium bis(fluorosulfonyl)imide (LiFSI), lithium hexafluorophosphate (LiPF6) and carbonates is proposed and tested in pilot‐scale, 2‐Ah pouch cells. Moreover, the origin of improved electrochemical performance is comprehensively studied via various characterizations, suggesting that the proposed HPE exhibits high ionic conductivity and excellent electrochemical stability at high charging rate of 6‐C. Therefore, the HPE‐based pouch cells deliver improved discharge specific capacity and excellent long‐term cyclability up to 1500 cycles under XFC conditions, which is superior to the conventional state‐of‐the‐art baseline electrolyte.
Cation and Anion Modulation Strategies toward Ideal Zinc Artificial Interface
Authors: Yang Jingjing , Zhang Anqi , Zhao Ran , Wu Chuan , Bai Ying 
Published: August 2023

AbstractAqueous zinc‐ion batteries (ZIBs) stand out as promising next‐generation energy storage systems. However, the Zn anode failure caused by the unstable Zn/electrolyte interface hinders their practical applications. Constructing artificial layer on the Zn surface provides an effective method to optimize the interfacial stability and mitigate the issues, while most of the current investigations put emphasis on the discussion of Zn2+ and H2O regulation, we notice that the anions and hydrogen evolution reaction (HER) intermediates also play a crucial role in the occurrence of side reactions, thus a comprehensive evaluation of interfacial modulation strategies regarding all the different ion species in ZIBs system is helpful for developing advanced artificial interface. Herein, this work systematically reviews the achievements about cation and anion modulation strategies for stabilizing Zn/electrolyte interface and emphasizes on the relationship between the material properties and ionic regulation mechanisms for the first time, aiming to provide an unprecedented design reference. Furthermore, some noteworthy points and perspectives are proposed, which has guiding significance for the realization of high‐performance and multi‐level regulated Zn anode.
Power, positionality and practitioner research: Schoolteachers' experiences of professional doctorates in education
Authors: Czerniawski Gerry 
Published: August 2023

AbstractThe growth, internationally, in professional doctorates over the last 25 years has been well documented, as are the forms, fields and disciplines that such doctorates embrace. Yet relatively little is known about the professional tensions teachers encounter, in relation to their positionality, when carrying out doctoral research in the schools where they work. This paper draws attention, not only to the contribution the Professional Doctorate in Education (EdD) makes to research as a whole, but also to the significance of teachers as invaluable members of the research community. Findings will be presented from interviews with 30 senior teachers from schools in England who are carrying out practitioner research as part of their doctoral studies. The paper draws attention to how power relations in the research process ferment the structural and agentic concerns of the participants in this study when discussing their researcher positionality. The scholarly significance of this study is its contribution to knowledge of how schools are increasingly becoming both sites of research and research‐rich environments. With its focus on researcher positionality the paper draws attention not just to the tensions and dilemmas these participants encounter on their doctoral journey, but also to the importance of teacher researchers and their role in research knowledge production.
Post‐remission cytopenia management in patients with AML treated with venetoclax in combination with hypomethylating agents: Pre‐ versus post‐VIALE‐A real‐world experience from a predominantly US community setting
Authors: Vachhani Pankit , Ma Esprit , Xu Tao , Montez Melissa , Worth Sarah , Yellow‐Duke Archibong , Cheng Wei‐Han , Werner Michael E. , Abbas Jonathan , Donnellan William 
Published: August 2023

AbstractBackgroundThis retrospective cohort study used an electronic health record‐derived, de‐identified, US patient‐level database to better understand the real‐world treatment experience, in a predominantly community setting (80.3% of patients), of venetoclax+hypomethylating agents (HMAs) in routine clinical care, pre‐ and post‐VIALE‐A, to determine whether the post‐remission cytopenia management insight from VIALE‐A was reflected in real‐world clinical practice.MethodsPatients with newly diagnosed acute myeloid leukemia (AML; N = 498), who initiated venetoclax+HMA ≤30 days from AML diagnosis from June 1, 2018, to March 31, 2021, were stratified into pre‐(n = 330) and post‐(n = 168) VIALE‐A cohorts.ResultsMore patients in the post‐(61%) versus pre‐(45%) VIALE‐A cohort had their first biopsy by 28 ± 14 days post‐treatment initiation. Patients underwent bone marrow (BM) assessment earlier in the post‐ versus pre‐VIALE‐A cohort, and first identification of response was also earlier (2.5 vs 5.1 months, respectively). More venetoclax schedule modifications post‐remission occurred among post‐(82.1%) versus pre‐(73.8%) VIALE‐A responders; the most common reason for modification was treatment toxicities, specifically cytopenia. Treatment survival outcomes were comparable with or without venetoclax schedule modifications.ConclusionsFindings suggest that venetoclax schedule modifications can be used to manage cytopenia events without adversely affecting outcomes. Opportunities remain to improve earlier BM assessment to determine venetoclax schedule modifications, providing the best chance for optimal treatment outcomes.
Entecavir‐induced neutropenia in an adult living donor liver transplant recipient: Successful conversion to tenofovir alafenamide
Authors: Lim I. Vern , Yurttaş Nurgül Özgür , Ayer Mesut , Poturoğlu Şule , Kınacı Erdem , Özden İlgin 
Published: August 2023

Key Clinical MessageAt 22 weeks post‐transplantation for HBV‐related cirrhosis, an adult woman developed neutropenia which was aggravated by COVID‐19 (ANC 0.4 × 109/L). Covid resolution and all “conventional” modifications were ineffective. Success within 2 weeks was achieved by switching entecavir to tenofovir alafenamide. A step‐by‐step judicious approach to post‐transplant neutropenia is vital.
A case report of hypokalemic periodic muscular weakness secondary to Sjögren's syndrome with distal renal tubular acidosis
Authors: Iqbal Marhaba , Khan Qaisar Ali , Belay Naod F. , Azeem Moheem , Amatul‐Hadi Faiza , Afzal Muhammad , Pande Harshawardhan , Shah Syed Yasir , Ahmed Rahma , Iram Sumaira , Verma Ravina 
Published: August 2023

Key Clinical MessageAn underlying autoimmune condition should be suspected in patients who presented with periodic muscular weakness secondary to distal RTA that leads to hypokalemia because distal RTA is commonly associated with autoimmune disorders such as Sjögren's syndrome.AbstractA 22‐year‐old female presented with a sudden onset of bilateral weakness in both upper and lower limbs. The patient had a history of muscular weakness secondary to hypokalemia and dryness of the eyes for the last 3 years. Laboratory investigations revealed decreased potassium and metabolic acidosis. Further investigations confirmed distal renal tubular acidosis (RTA) and Sjögren's syndrome. A diagnosis of distal RTA secondary to Sjögren's syndrome was made. Her potassium levels were replaced, and she was discharged with oral potassium supplements, steroids, and artificial tears.
Three‐dimensional transesophageal echocardiography‐guided transseptal puncture for percutaneous mitral valve edge‐to‐edge repair post‐percutaneous atrial septal defect closure
Authors: Tabata Hiroyuki , Isotani Akihiro , Shirai Shinichi , Ando Kenji 
Published: August 2023

Key Clinical MessageThree‐dimensional multiplanar analysis and real‐time three‐dimensional guidance using transesophageal echocardiography can help to identify and access the ideal position for transseptal puncture even in the presence of atrial septal occluders.AbstractTransseptal puncture (TSP) for the percutaneous mitral valve edge‐to‐edge repair (PMVR) after percutaneous atrial septal defect (ASD) closure is a rare and challenging issue. Here, we present a case illustrating the feasibility of real‐time three‐dimensional transesophageal echocardiographic guidance for TSP without ASD closure device injury.
Exploring adolescents' occupational possible selves: The role of gender and socioeconomic status
Authors: Li Yaoran , Du Hanxiang , Martin Ian , Hidalgo Edward , Jiang Yang , Xing Wanli , Popov Vitaliy 
Published: August 2023

AbstractAdolescence is an important stage in forming one's identity and developing career inspirations. The current empirical study aims to investigate gender and socioeconomic status (SES) differences in adolescents’ occupational possible selves. A total of 3336 sixth‐ to eighth‐grade students participated in the survey research and reported (1) hoped‐for occupation, (2) desire for the hoped‐for occupation, (3) likelihood of attaining the hoped‐for occupation, and (4) whether and what actions were taken toward the hoped‐for occupation. A series of regression models and advanced natural language processing techniques were applied to the survey data. Results revealed evident gender differences and some nuanced SES differences in the named occupational possible selves with a significant interaction between gender and SES on adolescents’ career‐related actions. However, this study did not find gender or SES differences in adolescents’ desire to pursue their occupational possible selves.
Sensitization patterns to cat molecular allergens in subjects with allergic sensitization to cat dander
Authors: Özuygur Ermis Saliha Selin , Norouzi Aram , Borres Magnus P. , Basna Rani , Ekerljung Linda , Malmhäll Carina , Goksör Emma , Wennergren Göran , Rådinger Madeleine , Lötvall Jan , Kankaanranta Hannu , Nwaru Bright I. 
Published: August 2023

AbstractBackgroundThe use of molecular allergology has increasingly become common in the diagnosis and management of allergic diseases. However, there is still a lack of data on cat molecular allergens in adults. Therefore, we aimed to uncover the sensitization patterns to cat molecular allergens.MethodsParticipants were recruited from the West Asthma Sweden Study, a population‐based study enriched with asthma subjects aged 16–75 years. Of 1872, 361 individuals were positive for cat dander immunoglobulin E and were further analysed for cat molecular allergens (Fel d 1/2/4/7). Sensitization patterns were classified as monosensitization, polysensitization, and concomitant sensitization, and were related to demographic and clinical measurements.ResultsAmong cat‐sensitized subjects, 84.2% were sensitized to secretoglobin, while 42.4% were sensitized to lipocalins. Nearly half of the subjects were monosensitized to Fel d 1. Polysensitization was observed in 20.2%, and concomitant sensitization to protein families was seen in 7.2%. Asthma prevalence, cat exposure, and rural living were associated with poly‐ and concomitant sensitization to protein families. Concomitant sensitization to single allergens was more common in those with asthma than in those without, while concomitant sensitization to both Fel d 1 and Fel d 4 was the most common pattern in individuals with asthma. Sensitization patterns also differed according to cat ownership and the degree of urbanization.ConclusionSensitization to molecular allergens was observed in 90.9% of cat‐sensitized subjects and showed variations across participants' background characteristics and the presence of asthma. Identification of sensitization patterns to cat allergens might provide better characterization of cat‐allergic subjects.
Exploration of the Pharmacophore for Cytoskeletal Targeting Ruthenium Polypyridyl Complexes
Authors: Reardon Melissa M. , Guerrero Matthew , Alatrash Nagham , MacDonnell Frederick M. 
Published: August 2023

AbstractRuthenium(II) trisdiimine complexes of the formula, [Ru(dip)n(L−L)3‐n]2+, where n=0‐3; dip=4,7‐diphenyl‐1,10‐phenanthroline; L–L=2,2’‐bipyridine (bpy) or 1,10‐phenanthroline (phen) were prepared and tested for cytotoxicity in two cell lines (H358, MCF7). Cellular uptake and subcellular localization were determined by harvesting treated cells and determining the ruthenium concentration in whole or fractionated cells (cytosolic, nuclear, mitochondrial/ ER/Golgi, and cytoskeletal proteins) by Ru ICP‐MS. The logP values for the chloride salts of these complexes were measured and the data were analyzed to determine the role of lipophilicity versus structure in the various biological assays. Cellular uptake increased with lipophilicity but shows the biggest jump when the complex contains two or more dip ligands. Significantly, preferential cytoskeletal localization is also correlated with increased cytotoxicity. All of the RPCs promote tubulin polymerization in vitro, but [Ru(dip)2phen]2+ and [Ru(dip)3]2+ show the strongest activity. Analysis of the pellet formed by centrifugation of MTs formed in the presence of [Ru(dip)2phen]2+ establish a binding stoichiometry of one RPC per tubulin heterodimer. Complexes of the general formula [Ru(dip)2(L−L)]2+ possess the necessary characteristics to target the cytoskeleton in live cells and increase cytotoxicity, however the nature of the L−L ligand does influence the extent of the effect.
A phase 2 study of ibrutinib maintenance following first‐line high‐dose methotrexate‐based chemotherapy for elderly patients with primary central nervous system lymphoma
Authors: Bairey Osnat , Taliansky Alisa , Glik Amir , Amiel Alexandra , Yust‐Katz Shlomit , Gurion Ronit , Zektser Miri , Porges Tzvika , Sarid Nadav , Horowitz Netanel A. , Shina Tzahala Tzuk , Lebel Eyal , Cohen Amos , Geiger Karyn Revital , Raanani Pia , Wolach Ofir , Siegal Tali 
Published: August 2023

AbstractBackgroundElderly patients account for nearly 70% of all primary central nervous system lymphoma (PCNSL) cases. They cannot tolerate aggressive treatment and have poor prognosis with a median overall survival (OS) of less than 2 years and progression‐free survival (PFS) of 6–16 months. Ibrutinib penetrates the blood–brain barrier and has shown activity in PCNSL.MethodsThis prospective study investigated whether ibrutinib maintenance is feasible, and whether it can benefit elderly PCNSL patients in terms of expected 2‐year PFS. It is an open label, phase 2 study in newly diagnosed PCNSL patients 60–85 years old who responded to first‐line high‐dose methotrexate (HDMTX)‐based treatment with partial or complete response. Ibrutinib maintenance (560 mg/d) was continued until disease progression or intolerable toxicity.ResultsTwenty patients were enrolled, with a median age of 72 years (range, 61–80). Median time on ibrutinib maintenance was 12.5 (range, 2–46) months. Twelve patients stopped treatment: five due to central nervous system relapse and seven due to adverse events that were mainly grade 2. Five patients died (25%) all due to relapse. The 1‐ and 2‐year PFS are 90% and 72.6%, respectively, and the 2‐year OS is 89%.ConclusionsThe study reached its primary end points and also showed that ibrutinib maintenance is tolerated reasonably well by the elderly. Therefore, this study supports the concept that ibrutinib maintenance should be further evaluated as an optional consolidation measure in the elderly.
Efficiency improvement of dual active bridge converter using simple graphical optimization method
Authors: Chen Zhangyong , Zheng Zhanchao , Tang Xuan , Wu Yunfeng , Xiang Tianyu 
Published: August 2023

SummaryAiming to the problems of high circulating current and low efficiency caused by the traditional strategy of dual active bridge (DAB) converter under light load, in this paper, simple graphical optimization method (GSO) is proposed to improve the efficiency of dual active bridge converter. Through the contour plot of transmission power and current stress, optimal efficiency point can be obtained by tangent of contour map under condition of constant power, and heavily calculation or complex iterations of existing conventional control strategies are avoided. Moreover, analysis of proposed graphical current stress optimization is addressed, and controller design of proposed method is given and described. Efficiency comparison between traditional modulation strategy and GSO is given to show the advantage of proposed mothed. An experimental prototype is built to verify the analysis.
Reconfigurable dual‐band wireless power transfer (RDB‐WPT) system using meander line for near‐field WPT applications
Authors: Atallah Hany A. , Hussein Rasha , Abdel‐Rahman Adel B. 
Published: August 2023

SummaryIn this work, the reconfigurable dual‐band wireless power transfer (RDB‐WPT) system is proposed. The studied system allows to transfer power or data in two frequency bands. The first band is tuned from 1.4 to 1.7 GHz while the second band is fixed at 2.17 GHz. The receiver circuit (Rx) is identical to the transmitter circuit (Tx), and they are coupled in back‐to‐back. The feed line is extended with a stub for matching, and it is built on the top layer. The meander line and the rectangular DGS are placed on the ground. The prototype is fabricated with a compact size of 30 × 15 mm2 to be used in small portable electronic devices. The measured efficiencies are 95% at the average of the tuned band and 92% at 2.17 GHz. Good agreements are achieved between the simulation, theoretical studies, and measurements.