bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transscleral Pars Plana Choroid Ablation Using the Iridex Laser System Yields Improvements for Surgical Insertion of the Port Delivery Implant in a Minipig Model
Authors: Shelton Amy , Schutten Melissa , Fuji Reina N. , Boyd Ryan , Stevenson Victoria , Leahy Matthew , Knupp Lauren , Lieng Juelline , Thompson Devon , Tam Tammy , LaMarche Kevin , Barteselli Giulio , Malhotra Varun , Bantseev Vladimir 
Published: January 2025

Purpose:
To evaluate an alternative surgical approach for Port Delivery System with ranibizumab (PDS) implant and a novel application of Iridex laser system in Gottingen minipig model.

Methods:
A total of seventeen male minipigs (Part 1: 9 animals in non-recovery and Part 2: 8 animals observed for 8-days post-surgery Part 2) received PDS implant insertion into each eye. The effect of Iridex 810 nm infrared diode laser with varying energy (power or duration) on transscleral pars plana ablation, surrounding ocular tissue and postsurgical vitreous hemorrhage (VH) was investigated.

Results:
The most effective laser parameters for transscleral pars plana ablation in mitigating vitreous hemorrhage with no surrounding tissue damage were continuous wave mode, 1750 mW, 1000 ms, and 16 spots (8 overlapping spots/sweep applied over 2 rows) across a 4 mm segment, posterior to the limbus, delivering a total energy of 28 J. Minimal self-limiting scleral hemorrhage was observed with two of the implants and no VH were observed. µCT imaging was consistent with clinical ophthalmic

observations.
On microscopic observations, no tissue damage was observed at these laser settings.

Conclusion:
This Göttingen minipig model demonstrated a novel application of Iridex laser for transscleral pars plana ablation that streamlines the PDS implantation surgery.
Predictors of Health Care Disparities in Fuchs Dystrophy Treatment Using the IRIS Registry
Authors: Jiang Yu , Davidson Oliver , Blazes Marian , Rajesh Anand E. , Lomazow Whitney , Bagsadarova Yelena , Lee Aaron Y. , Lee Cecilia S. , Sundararajan Miel ,   on behalf of the IRIS Registry Analytic Center Consortium
Published: January 2025

Purpose:
To evaluate associations between sociodemographic factors and surgical management in patients with Fuchs Endothelial Corneal Dystrophy (FECD).

Methods:
Patients >40 years old with FECD diagnosis and subsequent corneal edema between 2007 and 2020 were identified from the American Academy of Ophthalmology IRIS Registry (Intelligent Research in Sight). Multivariable Cox proportional hazards models were fit to examine the relationships between sociodemographic variables and time from FECD diagnosis to penetrating keratoplasty (PK) and endothelial keratoplasty (EK)/PK.

Results:
A total of 20,366 patients with FECD diagnosis and subsequent corneal edema were identified. Of the 4313 patients who underwent either EK or PK (any surgery), 374 patients underwent PK, 4037 underwent EK, and 98 received both interventions. After controlling for age, sex, and insurance status, Black or African American patients were 1.48 times as likely (hazard ratio 1.48, 95% confidence intervals (CI), 1.06–2.07) to undergo PK as compared with White patients and were less likely to receive any surgery (HR 0.83, 95% CI, 0.74–0.94). Asian patients were less likely (HR: 0.57, 95% CI, 0.43–0.75) to undergo any surgery. Female patients were more likely to undergo PK and less likely to undergo any surgery than male patients, and older patients were less likely to undergo any surgery with each increasing decade of life. There were no significant differences when stratified by insurance type.

Conclusions:
Age, sex, race and ethnicity, and insurance type are associated with varying rates of different surgical interventions for FECD.
Laennec approach for anatomical liver resection assisted by laparoscopy or robotics: a multicenter cohort study
Authors: Li Binghua , Yin Dalong , Zhang Qifan , Qin Lei , Li Jianwei , Hong Zhixian , Zhu Peng , Ding Guangyu , Shi Zhitian , Zhang Changhe , Zhang Kai , Peng Jin , Yue Yang , Chen Chaobo , Liu Lianxin , Zheng Shuguo , Chen Xiaoping , Gao Qiang , Zhang Bixiang , Yu Decai 
Published: January 2025

Introduction:
Laennec’s capsule serves as a critical anatomical landmark in liver resection. Despite its potential, a lack of large-scale prospective studies limits the widespread use of the Laennec approach for minimally invasive hepatectomy. This multicenter cohort study aimed to compare the outcomes of the traditional and Laennec approaches in minimally invasive anatomical hepatectomy across multiple centers in China.

Methods:
A total of 445 patients from 11 centers were included, with 339 undergoing the Laennec approach and 106 receiving the traditional approach. Intraoperative parameters such as the duration of hepatic pedicle isolation, hepatic vein exposure, parenchymal transection, and liver mobilization were analyzed. Postoperative outcomes, including recurrence-free survival and R0 resection rates, were also assessed. Additionally, a series of subgroup analyses were conducted to evaluate the efficacy of the Laennec approach.

Results:
The Laennec approach demonstrated notable intraoperative advantages, including reduced durations for hepatic pedicle isolation, liver mobilization, hepatic vein exposure, and parenchymal transection. Robotic-assisted procedures, in particular, showed superior outcomes when compared with laparoscopic platform. The Laennec approach proved highly effective across various liver diseases, particularly hepatocellular carcinoma, hemangioma, and hepatolithiasis. The Laennec gap, a distinct gap between the liver parenchyma and surrounding vasculature, played a key role in identifying candidates for the Laennec approach. Subgroup analysis revealed that although the Laennec approach provides significant intraoperative benefits, these advantages do not seem not to translate into substantial postoperative improvements.

Conclusions:
The Laennec approach offers clear intraoperative advantages over the traditional approach when utilizing laparoscopic or robotic systems. These findings support the Laennec approach as a standardized technique for anatomical liver resection.
Chronic Liver Disease as a Risk Factor For Post-ERCP Complications
Authors: Changela Madhav , Bahirwani Janak , Tan Ernestine Faye , Patel Nishit , Basida Sanket , Kaneriya Maulik , Singh Amanda , Mehta Deep , Suthar Kaushalkumar , Duarte-Chavez Rodrigo 
Published: January 2025

Introduction:
Endoscopic retrograde cholangiopancreatography (ERCP) is indicated for multiple pancreatic and biliary pathologies and carries a heightened risk profile compared with other endoscopic procedures. Considerable research has been directed towards discerning risk factors associated with complications such as post-ERCP pancreatitis and post-ERCP bleeding. Despite this, data on chronic liver disease (CLD) as a risk factor for complications is limited. We aimed to assess the outcomes of patients with CLD who underwent therapeutic or diagnostic ERCP to determine whether these patients had different outcomes relative to patients without CLD.

Methods:
We used the National Inpatient Sample (NIS) database to inquire for all adult patients who underwent ERCP between 2016 and 2019 using the International Classification of Disease, Tenth Revision (ICD-10) coding. The group was stratified into 2 groups: patients with CLD and those without. The main outcome we looked at was the rate of post-ERCP pancreatitis, post-ERCP hemorrhage, and perforation between the 2 groups. The secondary outcomes were in-hospital mortality and length of stay. A multivariate regression model was used to estimate the association of CLD with ERCP outcomes.

Results:
We identified a total of 883,825 patients who underwent ERCP between 2016 and 2019. Among these, 21,212 (2.4%) had CLD and 862,613 (97.6%) did not have CLD. The mean age for patients in liver disease group was 61.66 years and in group without liver disease was 60.46 years. The predominant ethnicity in both groups was whites. Additional admission-related factors are outlined in Table 1. The rate of post-ERCP pancreatitis (8.8% vs. 6.7%, P < 0.001) with adjusted odds ratio (aOR) 1.3; and post-ERCP hemorrhage (8.8% vs. 6.69%, P < 0.001) with aOR 1.35, was higher in the patient group with CLD. The rate of post-procedure perforation was not significantly different in both groups. For secondary outcomes; the in-hospital mortality (3.03% vs. 1.58%, P < 0.001) and length of stay (7 days vs. 3 days, P < 0.001) were higher in the patients with chronic liver disease. The outcomes are mentioned in Table 2.

Conclusion:
Although ERCP is considered a safe procedure, it is one of the endoscopic procedures associated with the highest risk of complications. As a result, risk stratification is crucial. Certain demographics, conditions like end-stage renal disease, liver cirrhosis, and procedural factors have been identified as risk factors for post-ERCP complications. Our study represents newer data, with use of revised ICD codes, to demonstrate increased risk in patients with liver disease. On the basis of these results, ERCP should be used judiciously in this population and further studies are required for identifying reversible risk factors to improve outcomes.
Noncardiac surgery for severe pulmonary hypertension: two surgeries in one patient and a review of the literature
Authors: Wiewiora Maciej , Nowowiejska–Wiewiora Alicja , Gasior Mariusz , Piecuch Jerzy 
Published: January 2025

Background:
Budd–Chiari syndrome is a rare and severe vascular liver disease. We presented patient with fulminant liver failure secondary to leiomyosarcoma of the IVC and thrombosis

Case presentation:
A 44-year-old female presented with fulminant liver failure secondary to inferior vena cava (IVC) thrombosis. Contrast-enhanced computed tomography subsequently revealed a thrombus within the IVC, extending cranially to the right atrium and caudally to the renal veins. The patient’s condition, characterized by early comatose symptoms, necessitated surgical intervention. Under extracorporeal circulation, a right atriotomy with thrombus lesion removal and descending thrombectomy of the IVC was performed. Hepatic congestion resolved after the thrombus was removed. A pathological examination of the excised thrombus revealed the presence of high-grade leiomyosarcoma.

Conclusions:
In cases where a thrombus extends from the IVC to the right atrium, urgent surgical intervention with extracorporeal circulation should be considered.
A case of sustained fetal atrial flutter at 25-week gestation: diagnostic challenges and therapeutic strategies
Authors: Qatza Ayham , Tawashi Kenana , Sheikh Sobeh Ahmed , Takkem Saleh 
Published: January 2025

Introduction:
Sustained fetal tachycardia is an uncommon phenomenon in gestations (approximately 0.1%). Atrial flutter (AF) accounts for 10–30% of fetal tachyarrhythmias, which is characterized by a rapid atrial rate estimated at 300–600 beats per minute, associated with variable degrees of atrioventricular conduction.

Case presentation:
A 29-year-old asymptomatic woman, pregnant for the third time, was diagnosed with a male fetus at 25 weeks gestation exhibiting sustained atrial flutter with rapid ventricular response (2:1 and 1:1 AV block). Maternal digoxin reduced the fetal ventricular rate to 120 bpm, mitigating hydrop risk. The infant was delivered via cesarean at 35 weeks, presenting with low blood pressure (80/50 mmHg) and an irregular pulse (160 bpm). The electrocardiogram showed AF; intravenous amiodarone was administered, and the rhythm successfully converted to a normal sinus rhythm.

Clinical discussion:
Fetal arrhythmias in pregnant women require detailed assessment and treatment, including maternal history, electrocardiogram, and renal function assessment. The approach to treatment involves the use of transplacental antiarrhythmics, where digoxin is considered the first line of treatment. Other options include sotalol and flecainide. The mother should be monitored for side effects, with follow-up in the postpartum period for the infant.

Conclusion:
Fetal AF may occur in the second trimester and requires an increased awareness of this life-threatening arrhythmia. Whatever the gestational age, early recognition of fetal tachycardia is important due to the potential for adverse and life-threatening outcomes.
Returning to Work After Cancer Treatment: An Exploratory Sequential Mixed-Methods Study Guided by Transitions Theory
Authors: Galica Jacqueline , Alsius Agnès , Walker Lauren , Stark Debora , Noor Hamza , Kain Danielle , Booth Christopher , Wickenden Amy 
Published: January 2025

Background
Although many individuals return to work after cancer treatment, supports to facilitate this transition are ineffective or lacking. Transitions Theory can be useful to conceptually explain the transition back to work after cancer; however, no known studies have used Transitions Theory to empirically examine this transition.

Objective
To explore how and why Transition Theory concepts can be used to understand individuals’ transition back to work after cancer treatment.

Methods
Using an explanatory sequential mixed-methods design, breast or colorectal cancer survivors who had returned to work completed questionnaires aligned with Transitions Theory concepts. Spearman correlations were used to explore associations, and significant results were used to draft interview questions. One-to-one telephone interviews with a subsample of participants provided elaborations to quantitative results. Qualitative data were analyzed using template analysis.

Results
Among the 23 participants who returned questionnaires, most identified as female (n = 21 [91%]) and had been back at work for 28.9 months (range, 3-60). The sample’s productivity loss was 7.42%, indicating an incomplete mastery of their return to work. Only 2 significant associations were revealed with higher productivity loss: higher anxiety (r = 0.487, P = .019) and a greater number of unmet relational needs (r = 0.416, P = .048). Twelve participants engaged in interviews wherein explanations for quantitative results were uncovered.

Conclusions
To support a smoother transition back to work after cancer, assessment and interventions should focus on individuals’ psychological well-being and relationship needs.

Implications for Practice
Transitions Theory can be useful in developing interventions to support a successful return to work after cancer.
Mediating Role of Parent-Child Conflict in the Association Between Parental Anxiety and Emotional Behavioral Problems Among Children With Leukemia
Authors: Wang Mengjia , Hu Ziyue , Xiang Mingli , Lin Jia , Zhang Ruixing 
Published: January 2025

Background
There is a documented risk of emotional and behavioral disorders in children with leukemia. Assessing the factors contributing to their behavioral disorders is particularly important from a prevention perspective.

Objective
The aim of this study was to study the influencing factors of internalizing and externalizing behaviors in children with leukemia from the perspective of adult family members.

Methods
Cluster sampling was utilized to recruit a sample of 219 children diagnosed with leukemia. The caregivers of these children completed assessments on parental anxiety, parent-child conflict, and internalizing and externalizing child behavior problems.

Results
Study findings indicate that children diagnosed with leukemia exhibit significant internalizing and externalizing behavior problems. Parental anxiety has a positive direct impact on both the internalizing and externalizing behavioral difficulties experienced by their children. Furthermore, parental anxiety indirectly influences the occurrence of internalizing and externalizing behavior problems through parent-child conflict.

Conclusion
Findings underscore the potential for enhancing the parent-child relationship as a means to mitigate children’s internalizing and externalizing problems by reducing parent-child conflict and parental anxiety.

Implications for Practice
The child and family-centered care approach in pediatric nursing is fundamental in assessing and addressing the needs of the child and family. To ameliorate emotional behavior issues in children with leukemia, the quality of the parent-child relationship needs to be considered as a pivotal component of family-based interventions and clinical practice.
Remote Symptom Monitoring in Thoracic Surgery Patients After Discharge
Authors: Sewell Marisa , Boerner Thomas , Harrington Caitlin , Hsu Meier , Tan Kay See , Carr Rebecca A. , Jones Susan , Zocco Daniel , Adusumilli Prasad S. , Bains Manjit S. , Bott Matthew J. , Downey Robert J. , Huang James , Isbell James M. , Park Bernard J. , Rocco Gaetano , Rusch Valerie W. , Sihag Smita , Jones David R. , Cracchiolo Jennifer , Molena Daniela 
Published: January 2025

Objective:
Evaluate an electronic platform for remote symptom monitoring to enhance postdischarge care in thoracic surgery using patient reporting of symptoms.

Summary Background Data:
Owing to the increased use of enhanced recovery after surgery protocols, patients are spending a larger portion of their postoperative course at home. For patients undergoing complex operations, this represents an opportunity for early identification of abnormal symptoms at home before deterioration.

Methods:
An online symptom-tracking platform for thoracic surgery patients was created on the basis of opinions from stakeholders and a review of the literature. Starting in February 2021, patients were educated about the symptom tracker in preoperative clinics. After discharge, patients received a series of electronic surveys covering 23 symptom domains assessed using a Likert scale for severity. Moderate symptoms prompted a “yellow alert,” and severe symptoms prompted a “red alert,” both notifying the nursing team and prompting appropriate action. Patients were considered responders if they completed at least 1 survey.

Results:
In total, 1997 patients were enrolled; 76% (n=1520) were responders. Responders were younger, more likely to be White, less likely to have medical comorbidities, and less likely to be readmitted (odds ratio, 0.53 [95% CI, 0.37-0.76]; P<0.001). Responders who were readmitted had a higher percentage of red alerts (47% vs. 24%; P<0.001) and yellow alerts (74% vs. 61%; P=0.016), compared with responders who were not readmitted.

Conclusions:
Electronic reporting adds an additional mechanism of communication between the patient and the clinical team, with the potential to lower the odds of readmission.
Mapping interactions within the NMD decapping complex reveals how Upf1 recruits Dcp2 onto mRNA targets
Authors: Ruiz-Gutierrez Nadia , Dupas Jeanne , Auquier Elvire , Barbarin-Bocahu Irène , Gaudon-Plesse Claudine , Saveanu Cosmin , Graille Marc , Hir Hervé Le 
Published: January 2025

ABSTRACTUpf1 RNA helicase is a pivotal factor in the conserved nonsense-mediated mRNA decay (NMD) process. Upf1 is responsible for coordinating the recognition of premature termination codons (PTC) in a translation-dependent manner and subsequently triggering mRNA degradation. Multiple factors assist Upf1 during these two consecutive steps. InSaccharomyces cerevisiae,Upf2 and Upf3 associated to Upf1 (Upf1-2/3) contribute to PTC recognition but are absent from the Upf1-decapping complex that includes Nmd4, Ebs1, Dcp1, and Dcp2. Despite their importance for NMD, the organization and dynamics of these Upf1-containing complexes remains unclear. Here, we show how distinct domains of Upf1 make direct contacts with Dcp1/Dcp2, Nmd4 and Ebs1 using recombinant proteins. These proteins also bind to each other forming an extended network of interactions within the Upf1-decapping complex. Dcp2 and Upf2 are shown to compete for the same binding site in the Upf1 N-terminal CH domain. This finding accounts for the isolation of two mutually exclusive Upf1-containing complexes from cell lysates. Furthermore, we show how Nmd4-assisted recruitment of Upf1 promotes the anchoring of the decapping protein to the mRNA.
Investigating the relationship between adolescent mental health and wellbeing in a nationally representative survey of 11-16 year olds in Wales
Authors: Mahedy Liam , McDonald Basil , Greene Giles , Davies Alisha , John Ann 
Published: January 2025

AbstractBackgroundImproving mental health (MH) and wellbeing (WB) of children is a national priority, yet there is no consensus on how these constructs are defined, nor the relationship between them. This is essential to ensure action is directed to where it has the greatest potential to prevent poorer MH and WB.MethodsThe School Health Research Network includes 191,975 pupils from 196 secondary schools in Wales (94% coverage of all schools). Annual pupil health survey data was used to investigate the relationship between MH (Strengths and Difficulties Questionnaire Total Difficulties (SDQTD)) and WB (Short Warwick-Edinburgh Mental Wellbeing Scale (SWEMWBS)) in a multilevel modelling framework. The primary sample size comprised any 11-to 16-year-old pupils with a pair of SWEMWBS and SDQTD scores in the 2019 or 2021 survey (N=191,975). Adjustment was made for variables hypothesised to influence MH or WB, grouped into demographic, behavioural, social, and structural domains.FindingsWorsening SDQTD categories predicted lower SWEMWBS scores in a clinically significant dose-response relationship in the fully adjusted model, ranging from slightly raised SDQTD (b= −1.68, 95% CI = −1.76, −1.61), high SDQTD (b= −2.41, 95% CI = −2.51, −2.31), and very high SDQTD (b= −3.63, 95% CI = −3.71, −3.55). Sensitivity analysis including pupils with missing SDQTD scores showed a similar pattern of results.ConclusionThese findings indicate a strong negative association between MH difficulties and WB among pupils in Wales. Determining whether treatment and prevention techniques for poor MH are shared or distinct could help allocate resources and efforts efficiently.
The origin and evolution of the gonococcal beta-lactamase plasmid, and implications for public health
Authors: Elsener T. A. , Cehovin A. , Philp C. , Fortney K. , Spinola S.M. , Maiden M.C.J. , Tang C.M. 
Published: January 2025

ABSTRACTNeisseria gonorrhoeaeis a leading cause of sexually transmitted infection (STI) and a priority AMR pathogen. Two narrow host range plasmids, pblaand pConj, have contributed to ending penicillin and tetracycline therapy, respectively, and undermine current prevention strategies including Doxy-PEP. Here, we investigated the origin and evolution of the beta-lactamase plasmid, pbla. We show that the interplay between pblaand pConj influences their co-occurrence and the spread of pblain the gonococcal population. We demonstrate that pblawas acquired by the gonococcus on at least two occasions fromHaemophilus ducreyi, and describe the subsequent evolutionary pathways taken by the three major pblavariants. Changes that mitigate fitness costs of pblaand the emergence of TEM beta-lactamases which confer increased resistance have contributed to the success of pbla. In particular, TEM-135, which has arisen in certain pblavariants, increases resistance to beta-lactams and only requires one amino acid change to become an extended spectrum beta-lactamase (ESBL). The evolution of pblaunderscores the threat of plasmid-mediated resistance to current therapeutic and preventive strategies against gonococcal infection. Given the close relationship between pblaand pConj, widespread use of Doxy-PEP is likely to promote spread of pConj and pbla, and emergence of plasmid-mediated ESBL in the gonococcus, with dire public health consequences.