bluuebunny/crossref_metadata_2025_split huggingface dataset:
FEM heat transfer modelling with tomography-based SiCf/SiC unit cell
Authors: Cavaliere Andrea , Marone Federica , Cozzo Cedric , Buchanan Karl , Lorrette Christophe , Pouchon Manuel A. 
Published: March 2023

Modern industry has become increasingly reliant on composite materials for a variety of applications, and the nuclear industry is no exception to this. Among the materials being researched as Enhanced Accident Tolerant Fuels, ceramic matrix composites such as SiC-fiber-reinforced SiC (SiCf/SiC) figure as some prime candidates due to their excellent high temperature performances. SiCf/SiC so far shows adequate nuclear, mechanical and chemical properties; still, the thermal properties need further investigation.
The thermal behavior of a material is an important factor for its performance as a nuclear fuel cladding, i.e. the first barrier encapsulating the fuel pellets. Many features determine the resulting properties of composite materials, such as matrix and fiber reinforcement properties and orientation, void fraction, and pore morphology. This study establishes a methodology to study the physical properties of composite materials and applies it to SiCf/SiC. A FEM model is used to characterize the thermal properties of a fundamental SiCf/SiC element, referred to as a �unit cell�, with the objective of accurately predicting the thermal properties of this complex class of materials where experimental data is often difficult to obtain. The unit cell is built based on data acquired with high-resolution tomographic microscopy performed at the TOMCAT beamline of the Swiss Light Source.
By using phase-retrieval prior to tomographic reconstruction, the pores, fibers and matrix that compose the material can be distinguished in the data analysis. The separated information is processed to obtain geometrical information about the individual pores and fibers, which is then used to parametrize them as cylindrical objects. This allows constructing a FEM model of a cubic unit cell that is used to extract the effective thermal properties of SiCf/SiC. The analysis scheme includes steady-state and dynamic thermal transport simulations, which yield directional effective thermal conductivity and diffusivity values, respectively. Both modes of analysis show isotropic thermal conductivity values in the range of 71 W/m/K at room temperature, more than three times that of currently employed nuclear cladding materials.
Combining these results with the data on the larger structural features of the material will lead to realistic results on the macroscopic thermal properties.
KARAKTERISTIK PASIEN KANKER ANAK BERDASARKAN USIA, JENIS KELAMIN, DAN JENIS-JENIS KANKER DI RSUD DR. H. ABDUL MOELOEK TAHUN 2021
Authors: Arania Resti , Alfarisi Ringgo , Rukmono Prambudi , Mustaghfirin Muhammad Fikri 
Published: March 2023

Kanker adalah sejumlah besar penyakit yang menyerang tubuh pada bagian mana saja. Kanker anak sendiri adalah kanker yang menyerang seseorang yang berumur dibawah usia 18 tahun bahkan ada beberapa kasus kanker menyerang pada janin yang masih terdapat didalam kandungan orangtua nya. Tujuan: Mengetahui gambaran karakteristik pada pasien kanker anak tahun 2021 di RSUD DR. H. Abdul Moeloek Provinsi Lampung. Metode: Jenis penelitian ini adalah analitik observasional, dengan rancangan penelitian cross-sectional, dan dengan pengumpulan data sekunder usia, jenis kelamin, dan jenis-jenis kanker. Klasifikasi usia disesuaikan menurut Departemen Kesehatan Republik Indonesia Tahun 2009. Pengambilan sampel menggunakan teknik consecutif sampling. Pengumpulan data dilakukan dengan cara melihat data rekam medik serta dianalisis menggunakan SPSS 26. Hasil: Didapatkan hasil dari 99 pasien dimana mayoritas pasien kanker anak adalah laki-laki sedangkan usia mayoritas pasien adalah usia dengan range 0-5 tahun dengan jenis kanker tersering yaitu leukemia. Kesimpulan: Hasil akhir pada kasus kanker anak menunjukan mayoritas penderita adalah laki-laki, dengan rentang usia terbanyak yaitu 0-5 tahun, dan di ikuti jenis kanker tersering di RSUD DR. H. Abdul Moeloek Provinsi Lampung adalah leukemia.
Robustness Study of a Tensile Modulus Prediction Model for Semicrystalline Polymers
Authors: Zarbali Ali , Pinke Balázs , Menyhárd Alfréd 
Published: March 2023

This work presents a robustness study of a previously developed empirical model that links Young's modulus to two key parameters of crystalline structure; crystallinity and lamellae thickness. The reliability of this modulus prediction model was tested by using different calorimeters and different polypropylene grades as well. Small samples were fabricated from injection-molded bars from different locations of the specimens in order to check the effect of structural inhomogeneity originated by the dynamic processing conditions. In addition, the standard deviation and consequently the accuracy of the prediction was tested by repeated calorimetric measurements. The crystalline structure and melting characteristics were measured by differential scanning calorimetry (DSC). The tensile properties of studied specimens were evaluated by standardized tensile tests. Although, the accuracy and reliability of the prediction model is dependent on the instrument used for thermal analysis, reasonably good agreement was found between the predicted and measured values in most cases. However, we may note that only well-calibrated calorimeters are suitable for reliable prediction of the modulus.
Efectos del yoga en la calidad de vida de pacientes pediátricos con diagnóstico de cáncer: un estudio piloto
Authors: Sanhueza-Ramírez Massiel , Oyanadel Cristián , Peñate-Castro Wenceslao 
Published: March 2023

Objetivo: Describir el efecto de un programa piloto de yoga en la calidad de vida de pacientes pediátricos con cáncer en tratamiento ambulatorio con quimioterapia.
Método: diseño mixto, cuasi-experimental, pre-post. Se reclutaron participantes entre 6 a 10 años, ocho completaron todo el programa. El programa consideró 6 sesiones grupales de Hatha yoga. Se utilizaron las escalas Calidad de Vida pediátrica versión genérica y específica del cáncer (Pediatric Quality of life inventory (PedsQl) 4.0 y 3.0). Se realiza una entrevista semi-estructurada para identificar beneficios percibidos por el/la cuidador/a.
Resultados: Los datos cuantitativos no muestran diferencias significativas en resultados de calidad de vida antes y después del programa, pero cualitativamente se reportaron beneficios en las entrevistas a cuidadores en las categorías del dolor, resistencia física y estado de ánimo.
Conclusiones: Este estudio piloto aporta a la implementación de futuras investigaciones que incorporen el yoga en oncología pediátrica en un entorno hospitalario.
Estratificação de risco em saúde mental para o processo de triagem em uma clínica escola
Authors: Corrêa Rafael , Goedert Amanda , Araújo Hemily , Barbosa Claudia 
Published: March 2023

Introdução: Considerando a demanda atendida em uma clínica-escola, se faz necessário uma classificação de risco para o planejamento e otimização dos atendimentos clínicos e programas em saúde mental.
Objetivo: Analisar a classificação de risco em saúde mental dos usuários de uma clínica-escola, a partir da triagem psicológica.
Metodologia: Pesquisa quantitativa, transversal e descritiva realizada com 85 participantes. Para análise dos dados foram utilizadas análises descritivas, na amostra geral e por sexo.
Resultados: A classificação de risco em saúde mental dos participantes foi de baixo risco, sendo mais frequente os sinais e sintomas como ansiedade, insônia, tristeza, desesperança, pensamentos de inutilidade e sentimento de culpa, com maior porcentagem nas mulheres.
Conclusão: O estudo confirma um baixo risco em saúde mental dos participantes da pesquisa, indicando a continuação do monitoramento dos dados e ampliação das estratégias utilizadas para o acompanhamento dos usuários, de saúde mental, na clinica-escola.
An automated system for cattle reproductive management under the IoT framework. Part I: the e-Synch system and cow responses
Authors: Ren Yue , Duhatschek Douglas , Bartolomeu Claudio C. , Erickson David , Giordano Julio O. 
Published: March 2023

The objective of this manuscript was to present the e-Synch system, integrating an intravaginal electronically controlled hormone delivery and sensing device with an IoT platform for remote programming and monitoring. Secondary objectives were to demonstrate system functionality and cow responses to e-Synch. External components of e-Synch include a 3D-printed case with retention wings, a flexible wideband antenna, and silicone membrane for pressure balancing. Internal components include a central control board, battery, wireless charging coil, and two silicone hormone reservoirs connected to individual peristaltic pumps. An accelerometer and a high-accuracy temperature sensor are integrated in the custom printed circuit board (PCB). The IoT platform includes a gateway consisting of Raspberry PI 3 and a CC1352 radiofrequency module that collects sensor data at 915 mHz. Data is transferred to the Google Cloud utilizing the IoT Core service through TCP/IP, and then is pulled by the Pub/Sub service. After routing to a BigQuery table by the Dataflow service, data visualization is provided by Data Studio. Drug delivery protocols are selected using an IOS device app that connects to e-Synch through Bluetooth. Experiments with lactating Holsteins cows were conducted to demonstrate proof-of-concept system functionality and evaluate cow responses. Despite unstable communication and signal discontinuity because of signal strength attenuation by body tissue, devices (n=6) communicated with the IoT platform in 89% (24/27) of use instances. Temperature and accelerometer data were received for at least one 15 min period during an 8 h insertion period from all devices that communicated with the IoT platform. Variation in accelerometer data (± 8.565 m/s2) was consistent with cow activity during experimentation and mean vaginal temperature of 39.1 °C (range 38.6 to 39.5 °C) demonstrated sensor functionality. Hormone release was confirmed in all instances of device use except for one. Cow behavior evaluated through signs of discomfort and pain, and tail raising scores was mostly unaltered by e-Synch. Vaginal integrity and mucus scores also remained unaltered during and after device insertion. In conclusion, the e-Synch device integrated with a controlling app and IoT platform might be used to automate intravaginal hormone delivery and sensing for controlling the estrous cycle of cattle.
NanoSIMS sulfur isotopic analysis at 100 nm scale by imaging technique
Authors: Hao Jia-Long , Zhang Liu-Ping , Yang Wei , Li Zhao-Yang , Li Rui-Ying , Hu Sen , Lin Yang-Ting 
Published: March 2023

NanoSIMS has been widely used for in-situ sulfur isotopic analysis (32S and 34S) of micron-sized grains or complex zoning in sulfide in terrestrial and extraterrestrial samples. However, the conventional spot mode analysis is restricted by depth effects at the spatial resolution &lt; 0.5–1 μm. Thus sufficient signal amount cannot be achieved due to limited analytical depths, resulting in low analytical precision (1.5‰). Here we report a new method that simultaneously improves spatial resolution and precision of sulfur isotopic analysis based on the NanoSIMS imaging mode. This method uses a long acquisition time (e.g., 3 h) for each analytical area to obtain sufficient signal amount, rastered with the Cs+ primary beam of ∼100 nm in diameter. Due to the high acquisition time, primary ion beam (FCP) intensity drifting and quasi-simultaneous arrival (QSA) significantly affects the sulfur isotopic measurement of secondary ion images. Therefore, the interpolation correction was used to eliminate the effect of FCP intensity variation, and the coefficients for the QSA correction were determined with sulfide isotopic standards. Then, the sulfur isotopic composition was acquired by the segmentation and calculation of the calibrated isotopic images. The optimal spatial resolution of ∼ 100 nm (Sampling volume of 5 nm × 1.5 μm2) for sulfur isotopic analysis can be implemented with an analytical precision of ∼1‰ (1SD). Our study demonstrates that imaging analysis is superior to spot-mode analysis in irregular analytical areas where relatively high spatial resolution and precision are required and may be widely applied to other isotopic analyses.
Case report: Novel three-dimensional echocardiographic methods mapping aortic root pseudoaneurysm secondary to blood culture-negative endocarditis with bicuspid aortic valve involvement
Authors: Miao Yue , Zhang Yanchao , Yue Ling , Guan Shuang , Feng Wei 
Published: March 2023

BackgroundInfective endocarditis (IE), though uncommon, is a potentially lethal disease. Blood culture-negative endocarditis (BCNIE) accounts for 2.5%–31% of all cases of IE and can lead to life-threatening complications, including aortic root pseudoaneurysm. It is associated with considerable diagnostic and therapeutic dilemmas. TrueVue and TrueVue Glass include the latest two technologies applied in advanced three-dimensional echocardiography, which allow for novel photorealistic images of cardiac structures, and provide abundant previously unavailable diagnostic information. Herein, based on a series of novel three-dimensional echocardiographic methods, we report a case of BCNIE with aortic valve involvement, leading to aortic valve perforation and prolapse, and developing into a giant aortic root pseudoaneurysm.Case summaryIn this study, we presented a case of a 64-year-old man exhibiting symptoms of intermittent fever, asthenia, and dyspnea following light exertion. Physical examination, laboratory tests, and electrocardiograms were suspected of IE, though the results of blood cultures were exactly negative. Three-dimensional transthoracic echocardiography, as well as a series of novel advanced techniques, was adopted to clearly visualize the lesions of the aortic valve and aortic root. However, despite active medical treatment modalities, the patient eventually suffered from a sudden, unexpected death 5 days later.ConclusionBCNIE with aortic valve involvement and development into a giant aortic root pseudoaneurysm is a rare and serious clinical event. In addition, TrueVue and TrueVue Glass offer unprecedented photographic stereoscopic images, enhancing the diagnostic performance of such structural heart diseases.
Antibiotic-laden bone cement for diabetic foot infected wounds: A systematic review and meta-analysis
Authors: Dong Tingting , Huang Qi , Sun Zengmei 
Published: March 2023

ObjectiveA large body of literature has demonstrated the significant efficacy of antibiotic bone cement in treating infected diabetic foot wounds, but there is less corresponding evidence-based medical evidence. Therefore, this article provides a meta-analysis of the effectiveness of antibiotic bone cement in treating infected diabetic foot wounds to provide a reference basis for clinical treatment.MethodsPubMed, Embase, Cochrane library, Scoup, China Knowledge Network (CNKI), Wanfang database, and the ClinicalTrials.gov were searched, and the search time was from the establishment of the database to October 2022, and two investigators independently. Two investigators independently screened eligible studies, evaluated the quality of the literature using the Cochrane Evaluation Manual, and performed statistical analysis of the data using RevMan 5.3 software.ResultsA total of nine randomized controlled studies (n=532) were included and, compared with the control group, antibiotic bone cement treatment reduced the time to wound healing (MD=-7.30 95% CI [-10.38, -4.23]), length of hospital stay (MD=-6.32, 95% CI [-10.15, -2.48]), time to bacterial conversion of the wound (MD=-5.15, 95% CI [-7.15,-2.19]), and the number of procedures (MD=-2.35, 95% CI [-3.68, -1.02]).ConclusionAntibiotic bone cement has significant advantages over traditional treatment of diabetic foot wound infection and is worthy of clinical promotion and application.Systematic review registrationPROSPERO identifier, CDR 362293.
Characterization of heterogeneous metabolism in hepatocellular carcinoma identifies new therapeutic target and treatment strategy
Authors: Yang Jiabin , Zeng Liangtang , Chen Ruiwan , Zheng Shangyou , Zhou Yu , Chen Rufu 
Published: March 2023

BackgroundMetabolic reprogramming is a well-known hallmark of cancer. Systematical identification of clinically relevant metabolic subtypes of Hepatocellular carcinoma (HCC) is critical to understand tumor heterogeneity and develop efficient treatment strategies.MethodsWe performed an integrative analysis of genomic, transcriptomic, and clinical data from an HCC patient cohort in The Cancer Genome Atlas (TCGA).ResultsFour metabolic subtypes were defined: mHCC1, mHHC2, mHCC3, and mHCC4. These subtypes had distinct differences in mutations profiles, activities of metabolic pathways, prognostic metabolism genes, and immune features. The mHCC1 was associated with poorest outcome and was characterized by extensive metabolic alterations, abundant immune infiltration, and increased expression of immunosuppressive checkpoints. The mHHC2 displayed lowest metabolic alteration level and was associated with most significant improvement in overall survival in response to high CD8+ T cell infiltration. The mHHC3 was a “cold-tumor” with low immune infiltration and few metabolic alterations. The mHCC4 presented a medium degree of metabolic alteration and high CTNNB1 mutation rate. Based on our HCC classification and in vitro study, we identified palmitoyl-protein thioesterase 1 (PPT1) was a specific prognostic gene and therapeutic target for mHCC1.ConclusionOur study highlighted mechanistic differences among metabolic subtypes and identified potential therapeutic targets for subtype-specific treatment strategies targeting unique metabolic vulnerabilities. The immune heterogeneities across metabolic subtypes may help further clarify the association between metabolism and immune environment and guide the development of novel strategies through targeting both unique metabolic vulnerabilities and immunosuppressive triggers.
A humanized anti-human adenovirus 55 monoclonal antibody with good neutralization ability
Authors: Chen Lei , Lu Jiansheng , Yue Junjie , Wang Rong , Du Peng , Yu Yunzhou , Guo Jiazheng , Wang Xi , Jiang Yujia , Cheng Kexuan , Yang Zhixin , Zheng Tao 
Published: March 2023

BackgroundHuman adenovirus type 55 (HAdV55) has a re-emerged as pathogen causing an acute respiratory disease presenting as a severe lower respiratory illness that can cause death. To date, there is no HAdV55 vaccine or treatment available for general use.MethodsHerein, a monoclonal antibody specific for HAdV55, mAb 9-8, was isolated from an scFv-phage display library derived from mice immunized with the purified inactived-HAdV55 virions. By using ELISA and a virus micro-neutralization assay, we evaluated the binding and neutralizing activity of mAb 9-8 following humanization. Western blotting analysis and antigen-antibody molecular docking analysis were used to identify the antigenic epitopes that the humanized monoclonal antibody 9-8-h2 recognized. After that, their thermal stability was determined.ResultsMAb 9-8 showed potent neutralization activity against HAdV55. After humanization, the humanized neutralizing monoclonal antibody (9-8-h2) was identified to neutralize HAdV55 infection with an IC50 of 0.6050 nM. The mAb 9-8-h2 recognized HAdV55 and HAdV7 virus particles, but not HAdV4 particles. Although mAb 9-8-h2 could recognize HAdV7, it could not neutralize HAdV7. Furthermore, mAb 9-8-h2 recognized a conformational neutralization epitope of the fiber protein and the crucial amino acid residues (Arg 288, Asp 157, and Asn 200) were identified. MAb 9-8-h2 also showed favorable general physicochemical properties, including good thermostability and pH stability.ConclusionsOverall, mAb 9-8-h2 might be a promising molecule for the prevention and treatment of HAdV55.
Pan-Cancer analysis and experimental validation identify the oncogenic nature of ESPL1: Potential therapeutic target in colorectal cancer
Authors: Zhong Yuchen , Zheng Chaojing , Zhang Weiyuan , Wu Hongyu , Wang Meng , Zhang Qian , Feng Haiyang , Wang Guiyu 
Published: March 2023

IntroductionExtra spindle pole bodies like 1 (ESPL1) are required to continue the cell cycle, and its primary role is to initiate the final segregation of sister chromatids. Although prior research has revealed a link between ESPL1 and the development of cancer, no systematic pan-cancer analysis has been conducted. Combining multi-omics data with bioinformatics, we have thoroughly described the function of ESPL1 in cancer. In addition, we examined the impact of ESPL1 on the proliferation of numerous cancer cell lines. In addition, the connection between ESPL1 and medication sensitivity was verified using organoids obtained from colorectal cancer patients. All these results confirm the oncogene nature of ESPL1.MethodsHerein, we downloaded raw data from numerous publicly available databases and then applied R software and online tools to explore the association of ESPL1 expression with prognosis, survival, tumor microenvironment, tumor heterogeneity, and mutational profiles. To validate the oncogene nature of ESPL1, we have performed a knockdown of the target gene in various cancer cell lines to verify the effect of ESPL1 on proliferation and migration. In addition, patients’ derived organoids were used to verify drug sensitivity.ResultsThe study found that ESPL1 expression was markedly upregulated in tumorous tissues compared to normal tissues, and high expression of ESPL1 was significantly associated with poor prognosis in a range of cancers. Furthermore, the study revealed that tumors with high ESPL1 expression tended to be more heterogeneous based on various tumor heterogeneity indicators. Enrichment analysis showed that ESPL1 is involved in mediating multiple cancer-related pathways. Notably, the study found that interference with ESPL1 expression significantly inhibited the proliferation of tumor cells. Additionally, the higher the expression of ESPL1 in organoids, the greater the sensitivity to PHA-793887, PAC-1, and AZD7762.DiscussionTaken together, our study provides evidence that ESPL1 may implicate tumorigenesis and disease progression across multiple cancer types, highlighting its potential utility as both a prognostic indicator and therapeutic target.
Treg-specific deletion of the phosphatase SHP-1 impairs control of inflammation in vivo
Authors: Gu QinLei , Tung Kenneth S. , Lorenz Ulrike M. 
Published: March 2023

IntroductionTo achieve a healthy and functional immune system, a delicate balance exists between the activation of conventional T cells (Tcon cells) and the suppression by regulatory T cells (Treg). The tyrosine phosphatase SHP-1, a negative regulator of TCR signaling, shapes this ‘activation-suppression’ balance by modulating Tcon cell resistance to Treg-mediated suppression. Treg cells also express SHP-1, but its role in influencing Treg function is still not fully understood. MethodsWe generated a Treg-specific SHP-1 deletion model, Foxp3Cre+ Shp-1f/f, to address how SHP-1 affects Treg function and thereby contributes to T cell homeostasis using a combination of ex vivo studies and in vivo models of inflammation and autoimmunity.ResultsWe show that SHP-1 modulates Treg suppressive function at different levels. First, at the intracellular signaling level in Treg cells, SHP-1 attenuates TCR-dependent Akt phosphorylation, with loss of SHP-1 driving Treg cells towards a glycolysis pathway. At the functional level, SHP-1 expression limits the in vivo accumulation of CD44hiCD62Llo T cells within the steady state Tcon populations (both CD8+ as well as CD4+ Tcon). Further, SHP-1-deficient Treg cells are less efficient in suppressing inflammation in vivo; mechanistically, this appears to be due to a failure to survive or a defect in migration of SHP-1-deficient Treg cells to peripheral inflammation sites.ConclusionOur data identify SHP-1 as an important intracellular mediator for fine-tuning the balance between Treg-mediated suppression and Tcon activation/resistance.