bluuebunny/crossref_metadata_2025_split huggingface dataset:
Some factors affecting the bioactive substances of lactogenic tea
Authors: Siripongvutikorn Sunisa , Kluabpet Chanisara , Anantapan Chaninat , Seechamnanturakit Vatcharee 
Published: August 2023

This study aims to perform the phytochemical screening composition for galactagogue herbs and determining the total phenolic (TPC) and flavonoid contents (TFC). Terpenes, saponins, tannins, alkaloids, phenolics, and flavonoids were found in water extracts of banana inflorescence (Musa sapientum L), white holy basil leaves (Ocimum sanctum L.), rhizomes of Thai ginger (Zingiber officinale Roscoe), and powdered lactogenic product. The results show that the TPC were greater than the TFC for all fresh parts of banana inflorescences. Following the M1 method, fresh banana floret gave the greatest TPC, superior to those with M2 or M3, while the TFC with M1 and M2 methods applied to banana floret was significantly greater than that of banana bracts or banana cores. After harvest and dehydration of the banana inflorescence, TPC and TFC after one-day storage were higher than those at five-days of storage. Meanwhile, TPC and TFC on both fresh and dehydrated white holy basil tended to decrease due to heat intolerance, deterioration, and brewing. In contrast, TPC and TFC of Thai ginger increased on dehydration. The maceration with press-shear force interaction (PAI) pretreatment, and with PAI combined with moist heat, strongly increase the bioactive contents. SEM imaging demonstrated that PAI with moist heat tended to enlarge the micro-pore volume and simultaneously increased pores, resulting in more adsorption of these compounds.
A cross sectional study on knowledge, attitude and practice regarding Covid vaccination among health beneficiaries
Authors: Nair Naveen S , Vidusha Karavadi Sri Sai , Jamal Saad 
Published: August 2023

In 2020, the whole world was taken aback by the emergence of a new viral disease – novel Corona Virus Disease (nCoViD-19), and soon the WHO declared it a pandemic. In India, two vaccines were developed and almost immediately approved for use, namely the Covishield and the Covaxin. These new vaccines and their fastened approval stirred a mixture of reactions both among the health care providers and the general public. : This pioneer study was conducted to assess the Knowledge, Attitude and Practice regarding CoViD vaccination among various beneficiaries.A cross-sectional questionnaire based study was conducted among various beneficiaries from January 25 to April 12 2021. Employing the stratified random sampling technique, 1000 study subjects were selected. After obtaining written informed consent, one to one interview was conducted. Knowledge, attitude and practice of CoViD vaccination was assessed using a grading system. 99.95% of Doctors and 49.0% of paramedical health care workers in contrast to 72.8% of general citizens had a good practise regarding vaccination and the pandemic in general. 64% of male study subjects had enrolled for vaccination on their self interest, in contrast with 75% of the 365 female study subjects. There was no statistically significant association between Gender and scores &#62;60% in Knowledge, Attitude and Practice regarding CoViD vaccination among the subjects. There was a statistically very high significance between Knowledge regarding vaccination and the independent decision to get vaccinated. Majority of the study population was willing to be vaccinated and the main reason attributed to this willingness was the belief that the vaccine is safe.
Neuro radio logic diagnostic evaluation of partial seizure in children’s
Authors: Vathada Tejanjani , Alishala Rajashekar 
Published: August 2023

: Seizures are characterized by abnormally excessive or synchronized neuronal activity in the brain. The purpose of the current study is to study etiology of partial seizure. To identify significant role of neuroimaging & EEG.: A cross sectional study involving a total 100 patients are recruited between 2-12 years. All the children aged 2 year to 12 years of age with partial seizures will undergo neuro imaging, plain and contrast (contrast where indicated). Out of 100 childrens 68% of the partial seizures in the age group 2 to 12 years occurred in younger children of 2-6 Years, while only 32% of the seizures occurred in 6 – 12 years of age group.. Among them, 75% of the cases revealed an identifiable cause in the CT brain and 63% of the cases showed abnormal EEG. Among the 75% with abnormal CT brain, 58 cases are identified as Neuroinfections, neurocysticercosis in 32 cases, Tuberculoma in 26 cases, 5 cases had infarct, 4 had Calcifications, 3 had Hydrocephalus, 2 had subdural effusion, 2 had AV malformations, 1 had brain tumour. Thus, partial seizures are the most prevalent neurological disorder in children, having a significant social and economic impact on developing country.. Frequently, even relatively benign, episodic spells are mistaken as seizures and even treated as such. Therefore, proper diagnosis and therapy should be emphasized more.
Análise cinemática da marcha de pacientes com amputação transfemoral e transtibial protetizados
Authors: Balardin Michele , Magnabosco Sabrina da Silva , Bonetti Leandro Viçosa , Zatta Patrícia Regina R. Pereira , Bernardon Dannielle Cristina S. , Saccani Raquel 
Published: August 2023

Objetivo: Analisar a cinemática linear da marcha de amputados transtibiais e transfemorais protetizados. Métodos: Amostra composta por 30 participantes, com idade superior a 20 anos, divididos em três grupos (Grupo TT: Indivíduos com amputação transtibial; Grupo TF: Indivíduos com amputação transfemoral; Grupo C: Indivíduos hígidos). A avaliação da marcha foi realizada por um sistema de cinemetria dotado de sete câmeras integradas. As variáveis cinemáticas lineares analisadas foram velocidade, cadência, tempo da passada, tempo de apoio simples, tempo de apoio duplo, comprimento da passada e largura da passada. Foi utilizada estatística descritiva, teste t independente, ANOVA com Post Hoc de Tukey e o teste Qui-quadrado de Pearson (?0,05). Resultados: Comparando os três grupos, houve diferença estatisticamente significativa nas variáveis velocidade (p?0,00), cadência (p?0,04), tempo da passada (p?0,00), tempo de apoio duplo (p?0,04) e comprimento da passada (p?0,04). Os grupos GTT e GTF foram mais lentos, quando comparadas ao GC. Contudo, os indivíduos do GTF apresentaram pior desempenho. Conclusões: conclui-se que há diferença na cinemática linear da marcha entre os amputados e os hígidos, e quanto mais alto o nível de amputação, maiores são os déficits na marcha.
Impact of CKRT and Hemoadsorption with CytoSorb on Antimicrobials Drugs Removal in Critically Ill Children with Septic Shock: A Single Center Prospective Study in a Pediatric Cohort
Authors: Bottari Gabriella , Goffredo Bianca , Marano Marco , Maccarrone Crisitna , Simeoli Raffaele , Bianco Giuseppe , Vallesi Leonardo , Beetham Joseph Charles Charlie , Mazzeo Anna Teresa , Cappoli Andrea , Cairoli Sara , Labbadia Raffaella , Cecchetti Corrado , Bernaschi Paola , Corsetti Tiziana , Morabito Santo , Taccone Fabio Silvio , Guzzo Isabella 
Published: August 2023

Background. Extracorporeal therapies (ET) are increasingly used in pediatric settings as adjuvant therapeutic strategies for overwhelming inflammatory conditions. Although these treatments seem to be effective for removing inflammatory mediators, their influence on antimicrobials pharmacokinetic should not be neglected. Methods: Prospective observational study of children admitted to the pediatric intensive care unit (PICU) with a diagnosis of sepsis/septic shock. All critically ill children received hemoadsorption treatment with Cytosorb (CS) in combination with CKRT. Therapeutic drug monitoring has been performed in 10 critically ill children, testing four antimicrobial molecules: meropenem, ceftazidime, amikacin and levofloxacin . In order to evaluate the total and the isolated CKRT and CS contribution to antibiotics removal, blood samples at each circuit point (post-hemofilter, post-CS and in the effluent line) were performed. Therefore Clearance and Mass Removal (MR) of hemofilter and CS were calculated. Results. Our preliminary report describes a different impact of CS on these target drugs removal: CS clearance resulted low for amikacine (6-12%), moderate for ceftazidime (43%) and moderate to high for levofloxacine (52-72%). Higher MR and clearance were observed with CKRT compared to CS. To the best of our knowledge this is the first report regarding pharmacokinetic dynamics in critically ill children treated with CKRT and CS for septic shock.
Decarbonisation of Offshore Oil & Gas Production Platforms a Case Study of the North Sea
Authors: Oluka N. , Iyalla I. , Mahon R. , Andrawus J. 
Published: August 2023

Abstract
The United Kingdom Continental Shelf (UKCS) of the North Sea Greenhouse gas emission from offshore oil & gas operations accounts for 14 mega tonnes of Co2 equivalent per annum, the majority of which comes from power generation for platforms (10 mega tonnes per annum of CO2 accounting for 70% of total CO2 emissions). In line with the COP 26 agreements and the Net Zero timeline, Green House Gas (GHG) emissions from power generation for offshore oil and gas platforms is one aspect that is key to the long-term decarbonisation of the North Sea.
In this paper the Sustainability Assessment approach of Multi Criteria Decision Analysis (MCDA) is used to analyse electrification options on a case study offshore oil and gas production platform in the North Sea by considering Technical, Economic and Environmental criteria. These sustainability indicator criteria are then evaluated using Simple Additive Weighting (SAW) to normalise decision making in the ranking process of electrification options.
The results show that decarbonisation of the offshore oil and gas platforms can be achieved by using the sustainability assessment approach to determine the best electrification option available to any offshore production platform.
Modular compliant cube with anisotropic nonlinear responsiveness
Authors: Mi Shengli , Yao Hongyi , Zhao Xiaoyu 
Published: August 2023

Abstract
Compliant mechanisms are a class of mechanical structures in which rigid joints are replaced by flexible components. With its simplified structure and high resilience, the flexible joints bring high precision, low cost and easy maintenance to the compliant mechanisms. However, mainstream compliant mechanisms respond linearly to external excitation via small elastic deformations (< 10%) and cannot expand their sizes and work collectively. Here, we propose an inverse design strategy which generating a family of modular compliant cubes (MCC) with a wide range of elastic deformations (25%~65%) from arbitrary cubic geometry. We found these cubes exhibited mechanical softening undergoing compression stimulus. Further, we built mechanical metamaterials as well as flexible robots by assembling MCCs. These metamaterials were hyperelastic, anisotropic, compressable. The modular flexible robot was metre-scale, free of complex pipelines and traversed complex scenarios on demand. We expect this strategy provide insights into the application of compliant mechanisms in large scale interdisciplinary applications.
Accurate solutions of interval linear quadratic regulator optimal control problems with fractional-order derivative
Authors: Allahdadi Mehdi , Soradi-Zeid Samaneh , Shokouhi Tahereh 
Published: August 2023

Abstract
In this study, the goal is to obtain optimal solutions of fractional interval linear quadratic regulator problems. The major contributions made in this paper is to apply an indirect approach based on the interval calculus of variations with a joint application of constrained interval arithmetic to transcribe the fractional problem under study into a system of Volterra integral equations. To do so, we present the fractional interval Pontryagin's minimum principle for the extraction of necessary optimality conditions. The obtained conditions are first transformed to a system of Volterra integral equations and then using the Laplace transform method, we solve these equations and obtained the optimal solutions. One of the key points of this method is to keeping the continuous form of the problems, which we can change it to an equivalent form without discretizing it, and proving the existence of its solution.
Some numerical examples are carried out to confirm the standard criteria with theoretically accurate results.
Soyabean Oil Concentration Dependent Abundance of Rhamnolipid Homologues Determines Microbial Enhanced Oil Recovery Efficacy In Pseudomonas aeruginosa RA5
Authors: Ankulkar Rutuja , Aphale Durgadevi , Chavan Meera 
Published: August 2023

Abstract
In the present research, we isolated rhamnolipid (RLs) biosurfactant producing Pseudomonas aeruginosa RA5 from oil contaminated refinery soil. The proportion of its major mono-RLs and di-RLs homologues; Rha-C10, Rha-C10-C10, Rha-Rha-C10, and Rha-Rha-C10-C10 was investigated with minor change in the Soyabean oil concentration from 2–4%. We report P. aeruginosa RA5 for its capacity to efficiently produce di-rhamnolipid (Rha-Rha-C10-C10) as the predominant component with 2% and 4% soybean oil as a sole carbon source, accounting for 3.7 % and 0.7% of total products, respectively. The critical micelle concentration (CMC) of rhamnolipid products varies with the content of di-rhamnolipid, whereby lower CMC values correspond to higher di-rhamnolipid contents. The rhamnolipids containing 3.7% di rhamnolipid had the lowest CMC value of 206 mg/L. Accordingly, the viscosity-reducing efficiency and oil-washing efficiency of rhamnolipids increased with the higher di-rhamnolipid component. At a concentration of 1000 mg/L, the rhamnolipids containing 3.7% di-rhamnolipid (Rha-Rha-C10-C10) worked best and showed 85% oil-washing efficiency, which offered great promise for applications in enhanced oil recovery. The results showed the variation of structure and composition of rhamnolipids had a significant effect on their application.
Population-specific reference panel improves imputation quality and enhances locus discovery and fine-mapping
Authors: Terao Chikashi , Flanagan Jack , Tomizuka Kohei , Liu Xiaoxi , Ortega-Reyes David , Matoba Nana , Akiyama Masato , Ishigaki Kazuyoshi , Ashikawa Kyota , Takata Sadaaki , Aoi Tomomi , Momozawa Yukihide , Ito Kaoru , Murakami Yoshinori , Matsuda Koichi , Kamatami Yoichiro , Morris Andrew , Horikoshi Momoko 
Published: August 2023

Abstract

In order to improve the imputation quality for genome-wide association studies (GWAS) conducted on the Japanese population, we created and assessed four Japanese population-specific reference panels. These reference panels were generated using whole genome sequencing (WGS) data, encompassing diverse sample sizes (3K ~7K Japanese enrolled through the Biobank Japan (BBJ) project), and varying sequencing depths (3× to 30×). An augmented reference panel that included 7,472 Japanese WGS of mixed depth (1000 genome project (1KG)+7K) provided the greatest improvement in imputation quality relative to the 1KG panel alone, with ~2× the total number of imputed variants and ~3.8x the number of “well-imputed” variants (defined by r2 > 0.3). Furthermore, most these improvements were observed for rare variants with a minor allele frequency (MAF) < 1%. To demonstrate the benefits of improved imputation in association analyses of complex traits, a GWAS of serum uric acid levels was performed after imputation up to the 1KG+7K panel. The analysis revealed four potentially novel loci at genome-wide significance (P<5×10-8) distinct from those previously reported. In summary, the augmented imputation panel demonstrates significant advantages in the discovery and fine-mapping of complex trait loci, particularly those influenced by low-frequency association signals.
Expert deduction rules in data mining with association rules: new results and challenges
Authors: Rauch Jan 
Published: August 2023

Abstract
The paper deals with applications of domain knowledge in data mining with association rules. We consider enhanced association rules – general relations of general Boolean attributes derived from columns of analyzed data matrices. The challenge is to filter out rules – consequences of given items of domain knowledge. The general syntax of enhanced rules motivated the study of logical calculi whose formulas conform to these rules. Deduction rules in such calculi have proven inadequate for dealing with domain knowledge. This led to the definition and study of expert deduction rules – incorrect deduction rules, which are, however, supported by indisputable facts on the whole calculus. Such expert deduction rules can remarkably reduce the number of output association rules by omitting the consequences of given items of domain knowledge. This concerns both the association rules produced by the apriori algorithm and the enhanced association rules. However, expert deduction rules are available only for association rules evaluated using the confidence measure of interest. New expert deduction rules for association rules evaluated using the lift measure of interest are defined and studied. Two case studies demonstrate their usefulness. Finally, new challenges to study expert deduction rules are formulated.
The sustainability of groundwater in semi-arid regions: the case of Makutupora Basin in Tanzania
Authors: Mseli Zaina Hussein , Said Alfred , Sankaranna Gaduputi , Mwegoha William John 
Published: August 2023

Abstract
Groundwater sustainability ensures groundwater development and uses to meet current and future needs without causing unacceptable environmental, economic, or social consequences. In semi-arid regions, water resources are typically limited, and water management is critical to ensure a sustainable water supply. Groundwater sustainability indexing is vital for groundwater management. The study used four indicators in six dimensions, i.e., quantitative and qualitative hydrogeology, environmental, social-economic, and political factors, to evaluate the sustainability of the aquifer in Makutupora basin, Dodoma, Tanzania. The resulting aquifer sustainability index is 0.59, with a 95% confidence interval between 0.3856 and 0.7944, showing that the aquifer is sufficiently sustainable. The hydrogeological analysis revealed that groundwater sustainability is promising, although groundwater use per capita is alarming. This study also recommends effective water management strategies, including improving water use efficiency, promoting water conservation, implementing policies to limit water withdrawals, and promoting alternative water sources such as recycled wastewater, especially for agricultural activities.
Drug Repurposing against Novel Therapeutic Targets in Plasmodium falciparum for Malaria: The Computational Perspective
Authors: Rai Shweta , Shukla Shruti , Scotti Luciana , Mani Ashutosh 
Published: August 2023

:
Malaria remains one of the most challenging tropical diseases. Since malaria
cases are reportedly alarming in terms of infections and mortality, urgent attention is
needed for addressing the issues of drug resistance in falciparum malaria. High throughput
screening methods have paved way for rapid identification of anti-malarial. Furthermore,
drug repurposing helps in shortening the time required for drug safety approvals.
Hence, discovery of new antimalarials by drug repurposing is a promising approach for
combating the disease. This article summarizes the recent computational approaches
used for identifying novel antimalarials by using drug target interaction tools followed by
pharmacokinetic studies.
Dietary, Herbal and Nutritional Interventions for Managing Rheumatoid
Arthritis: A Review
Authors: Verma Aanchal , Dubey Nandini , Agrawal Anant , Goyal Ahsas 
Published: August 2023

Abstract:
Rheumatoid Arthritis (RA) is a systemic, inflammatory disease that affects joints and
leads to progressive cartilage and bone deterioration. The susceptibility to RA is determined by
genetic and environmental factors. Recently, many efforts have been undertaken to develop natural
compounds capable of reducing the symptoms of RA to avoid the negative effects of the current
anti-inflammatory drugs. Interestingly, substantial data has revealed that nutritional, and herbal
supplements may be effective adjuvants in reducing the symptoms of RA by influencing the
pathogenic inflammatory processes. In this context, various kinds of food, phenolic substances,
spices like ginger, and turmeric, several vitamins, and probiotics are reported to control the activity
of inflammatory molecules implicated in the pathophysiology of RA and therefore, have proved
successful in slowing the course of this arthritic illness. Therefore, the goal of this review article is
to compile various findings on RA that have revealed illuminating information about the antiinflammatory,
antioxidant, analgesic, immunomodulatory, and bone erosion-preventing properties
of nutritional, and herbal components. Conclusively, this review concentrates on natural ingredients
that may enhance overall well-being, promote health, and lessen the risk of RA.
Neuropathic Pain in Aged People: An Unresolved Issue Open to Novel
Drug Approaches, Focusing on Painful Diabetic Neuropathy
Authors: Marchesi Nicoletta , Fahmideh Foroogh , Pascale Alessia , Allegri Massimo , Govoni Stefano 
Published: August 2023

Abstract:
A majority of older patients suffer from neuropathic pain (NP) that significantly alters their
daily activities and imposes a significant burden on health care. Multiple comorbidities and the risk of
polypharmacy in the elderly make it challenging to determine the appropriate drug, dosage, and
maintenance of therapy. Age-dependent processes play a contributing role in neuropathy given that diabetic
neuropathy (DN) is the most common form of neuropathy. This narrative review is mainly focused
on the drug treatment approach for neuropathy-associated pain in aged people including both
drugs and dietary supplements, considering the latter as add-on mechanism-based treatments to increase
the effectiveness of usual treatments by implementing their activity or activating other analgesic
pathways. On one hand, the limited clinical studies assessing the effectiveness and the adverse effects
of existing pain management options in this age segment of the population (> 65), on the other hand,
the expanding global demographics of the elderly contribute to building up an unresolved pain management
problem that needs the attention of healthcare providers, researchers, and health authorities as
well as the expansion of the current therapeutic options.
Inflammation in Posttraumatic Stress Disorder: Dysregulation or
Recalibration?
Authors: Patas Kostas , Baker Dewleen G. , Chrousos George P. , Agorastos Agorastos 
Published: August 2023

Abstract:
Despite ample experimental data indicating a role of inflammatory mediators in the behavioral
and neurobiological manifestations elicited by exposure to physical and psychologic stressors,
causative associations between systemic low-grade inflammation and central nervous system
inflammatory processes in posttraumatic stress disorder (PTSD) patients remain largely conceptual.
As in other stress-related disorders, pro-inflammatory activity may play an equivocal role in PTSD
pathophysiology, one that renders indiscriminate employment of anti-inflammatory agents of
questionable relevance. In fact, as several pieces of preclinical and clinical research convergingly suggest,
timely and targeted potentiation rather than inhibition of inflammatory responses may actually be
beneficial in patients who are characterized by suppressed microglia function in the face of systemic
low-grade inflammation. The deleterious impact of chronic stress-associated inflammation on the
systemic level may, thus, need to be held in context with the - often not readily apparent - adaptive
payoffs of low-grade inflammation at the tissue level.