bluuebunny/crossref_metadata_2025_split huggingface dataset:
O DIREITO AO ESQUECIMENTO COMO DIREITO DA PERSONALIDADE: RECONHECIMENTO E APLICABILIDADE PELOS TRIBUNAIS SUPERIORES / THE RIGHT TO FORGET AS A PERSONALITY RIGHT: RECOGNITION AND APPLICABILITY BY SUPREME COURTS
Authors: Santos Marques Dias Venanzoni Victória , Bertoncini Carla , Domingues Brito Jaime 
Published: June 2023

Resumo: O artigo objetiva analisar o direito ao esquecimento como direito da personalidade, que ganhou maior ênfase e discussão a partir da sociedade de informação, uma vez que o uso da internet e das redes sociais tornou mais fácil o acesso a dados e informações pessoais. Por meio do método dedutivo, são analisados o conceito e características dos direitos da personalidade, o conceito do direito ao esquecimento em específico, bem como quais são os direitos fundamentais que entram em confronto quando da sua discussão: os direitos à liberdade de expressão e de informação, direito à privacidade, intimidade e honra. Ainda, é feita uma explanação acerca do posicionamento das Cortes Superiores quanto ao seu reconhecimento e aplicação no ordenamento jurídico brasileiro. Finalmente, constata-se que o direito ao esquecimento está intimamente ligado ao primado da dignidade da pessoa humana. Por esse motivo, não sendo caso de relevante interesse público, pode ser aplicado em casos concretos, quando houver afronta à vida privada. A pesquisa, pois, contribui nas áreas do Direito Constitucional, Direitos Humanos e Fundamentais, Direito Civil, Direito Penal e Direito Digital.Palavras-chave: Liberdade de expressão. Direito à informação. Direito à privacidade. Direito à intimidade. Recurso Extraordinário 1.010.606/RJ. Abstract: The article aims to analyze the right to forget as a personality right, which has gained greater emphasis and discussion from the information society, since the use of internet and social networks has made it easier to access personal data and information. Through the deductive method, the concept and characteristics of personality rights are analyzed, as well as the concept of the right to forget in specific and which fundamental rights clashes when it is discussed: the rights to freedom of expression and information, the right to privacy, intimacy and honor. Furthermore, an explanation is made about the position of Supreme Courts regarding its recognition and application in Brazilian legal system. Finally, it is noted that the right to be forgotten is closely linked to the primacy of human dignity. For this reason, in the hypothesis of no relevant public interest, this right can be applied in specific cases, if private life is violated. The research contributes in Constitutional Law, Human and Fundamental Rights, Civil Law, Criminal Law and Digital Law.Keywords: Freedom of expression. Right to information. Right to privacy. Right to intimacy. Extraordinary Resource 1.010.606/RJ.
Acceptability and feasibility of video-based health education for maternal and infant health in Dirashe District, South Ethiopia: A qualitative study
Authors: Godana Boynito Wanzahun , Tessema Godana Yaya , Temesgen Kidus , De Henauw Stefaan , Abbeddou Souheila 
Published: June 2023

Evidence about innovative methods to facilitate nutrition education counseling and promote the intended behavior change at scale is limited. We assessed the acceptability and feasibility of a video-based health education intervention aiming to promote community care for pregnant women, mothers, and infants in the Dirashe District, Ethiopia. Using a phenomenological study design, the experiences of study participants in a trial testing the effectiveness of video-based health education on birth outcomes and nutritional status of mothers and their infants six months postpartum were assessed. Focus group discussions (FGDs) and key informant interviews (KIIs) were used to collect the data. The study was conducted in the Dirashe District, South Ethiopia. Five FGDs and 41 KII were conducted among video implementers, mothers, nurses, and health extension workers (HEWs) in eight intervention villages. All data were collected with a tape recorder. The tape-recorded data were transcribed and then translated into English. Data were analyzed using thematic content analysis. The videos delivered messages about nine themes on health, nutrition, and hygiene related to mothers and infants. Overall, the video-based health education interventions was acceptable and feasible. Messages delivered were found to be clear, easily understandable, culturally acceptable, and relevant to the needs of the mothers. Feasibility was affected by the nature of the work, lack of help, and overlapping duties of the HEWs. The video-based health education intervention was acceptable and feasible. It was suggested that determining a common location/venue to show the videos, involving husbands, and involving HEWs could improve the intervention.
Trial registration: The effectiveness “parent” study was registered as a clinical trial with the U.S. National Institute of Health (www.ClinicalTrials.gov; NCT04414527). The qualitative study included recipients from the same cohort (participating mothers from the intervention group), in addition to video implementers, health extension workers the Health Development Army, and nurses from the intervention communities.
High transmission efficiency of the simian malaria vectors and population expansion of their parasites Plasmodium cynomolgi and Plasmodium inui
Authors: Jeyaprakasam Nantha Kumar , Low Van Lun , Pramasivan Sandthya , Liew Jonathan Wee Kent , Wan-Sulaiman Wan-Yusoff , Vythilingam Indra 
Published: June 2023

Background
The elimination of malaria in Southeast Asia has become more challenging as a result of rising knowlesi malaria cases. In addition, naturally occurring human infections with other zoonotic simian malaria caused by Plasmodium cynomolgi and Plasmodium inui adds another level of complexity in malaria elimination in this region. Unfortunately, data on vectors which are responsible for transmitting this zoonotic disease is very limited.

Methodology/Principal findings
We conducted longitudinal studies to investigate the entomological parameters of the simian malaria vectors and to examine the genetic diversity and evolutionary pattern of their simian Plasmodium. All the captured Anopheles mosquitoes were dissected to examine for the presence of oocysts, sporozoites and to determine the parous rate. Our study revealed that the Anopheles Leucosphyrus Group mosquitoes are highly potential competent vectors, as evidenced by their high rate of parity, survival and sporozoite infections in these mosquitoes. Thus, these mosquitoes represent a risk of human infection with zoonotic simian malaria in this region. Haplotype analysis on P. cynomolgi and P. inui, found in high prevalence in the Anopheles mosquitoes from this study, had shown close relationship between simian Plasmodium from the Anopheles mosquitoes with its vertebrate hosts. This directly signifies the ongoing transmission between the vector, macaques, and humans. Furthermore, population genetic analysis showed significant negative values which suggest that both Plasmodium species are undergoing population expansion.

Conclusions/Significance
With constant microevolutionary processes, there are potential for both P. inui and P. cynomolgi to emerge and spread as a major public health problem, following the similar trend of P. knowlesi. Therefore, concerted vector studies in other parts of Southeast Asia are warranted to better comprehend the transmission dynamics of this zoonotic simian malaria which eventually would aid in the implementation of effective control measures in a rapidly changing environment.
Factors that influenced utilization of antenatal and immunization services in two local government areas in The Gambia during COVID-19: An interview-based qualitative study
Authors: Bah Abdourahman , Russo Giuliano 
Published: June 2023

Introduction
Evidence is being consolidated that shows that the utilization of antenatal and immunization services has declined in low-income countries (LICs) during the COVID-19 pandemic. Very little is known about the effects of the pandemic on antenatal and immunization service utilization in The Gambia. We set out to explore the COVID-19-related factors affecting the utilization of antenatal and immunization services in two Local Government Areas (LGAs) in The Gambia.

Methods
A qualitative methodology was used to explore patients’ and providers’ experiences of antenatal and immunization services during the pandemic in two LGAs in The Gambia. Thirty-one study participants were recruited from four health facilities, applying a theory-driven sampling framework, including health workers as well as female patients. Qualitative evidence was collected through theory-driven semi-structured interviews, and was recorded, translated into English, transcribed, and analysed thematically, applying a social-ecological framework.

Results
In our interviews, we identified themes at five different levels: individual, interpersonal, community, institutional and policy factors. Individual factors revolved around patients’ fear of being infected in the facilities, and of being quarantined, and their anxiety about passing on infections to family members. Interpersonal factors involved the reluctance of partners and family members, as well as perceived negligence and disrespect by health workers. Community factors included misinformation within the community and mistrust of vaccines. Institutional factors included the shortage of health workers, closures of health facilities, and the lack of personal protective equipment (PPEs) and essential medicines. Finally, policy factors revolved around the consequences of COVID-19 prevention measures, particularly the shortage of transport options and mandatory wearing of face masks.

Conclusions
Our findings suggest that patients’ fears of contagion, perceptions of poor treatment in the health system, and a general anxiety around the imposing of prevention measures, undermined the uptake of services. In future emergencies, the government in The Gambia, and governments in other LICs, will need to consider the unintended consequences of epidemic control measures on the uptake of antenatal and immunization services.
Effect of linezolid on platelet count in critically ill patients with thrombocytopenia
Authors: Tatsumi Hiroomi , Akatsuka Masayuki , Kuroda Hiromitsu , Kazuma Satoshi , Suzuki Shintaro , Masuda Yoshiki 
Published: June 2023

Introduction
Linezolid (LZD) is one of the antibiotics used to treat methicillin-resistant Staphylococcus aureus. In Japan, the dose of LZD is not generally adjusted by renal function or therapeutic drug monitoring and is readily available for critically ill patients. The adverse effects of LZD include pancytopenia, especially thrombocytopenia. We investigated the effect of LZD on platelet counts in critically ill patients with thrombocytopenia during admission to the intensive care unit (ICU).

Methods
Fifty-five critically ill patients with existing thrombocytopenia (platelet count < 100 ×103 /μL) who received LZD for five days or more during the period from January 2011 to October 2018 were included. Changes in platelet count and frequency of platelet concentrate (PC) transfusion were evaluated retrospectively.

Results
Mean (± standard error) platelet count prior to initiation of LZD was 47 ± 4 ×103 /uL, which increased significantly to 86 ± 13 ×103 /uL on day 15 (p<0.01). Median [interquartile range] duration of LZD therapy was 9 [8–12] days. Thirty-two patients (58.2%) required PC transfusion in the 15-day study period. The daily rate of PC transfusion decreased from 30.2% on days 1–5 to 18.2% on days 11–15. Similar tendencies were observed in patients with non-hematological and hematological disease.

Conclusion
Thrombocytopenia in critically ill patients in the ICU did not worsen after initiation of LZD therapy, and may be considered for the treatment of MRSA in this setting.
Clinical course of new-onset Crohn’s disease in children and adolescents in dependency of age, initial location, initial severity level and therapy over the period 2000–2014 based on the Saxon Pediatric IBD-Registry in Germany
Authors: Dong Fan , Kern Ivana , Weidner Jens , Kügler Kathleen , Rothe Ulrike , Amin Makan , Laaß Martin W. , Flemming Gunter , Winkler Ulf , Richter Thomas , Kugler Joachim , Manuwald Ulf 
Published: June 2023

Objective
In Saxony, the incidence of Crohn’s disease (CD) in children and adolescents increased significantly from 3.3 per 100,000 person-years in 2000 to 5.1 in 2014. The aim of this study was to describe the initial characteristics and the clinical course of CD in children and adolescents and to identify drug treatment options associated with an advantage for a mild course or remission.

Methods
Clinical data were collected from patients who suffered from inflammatory bowel disease (IBD) and were recruited in the Saxon Pediatric IBD-Registry. All children newly diagnosed with CD in this registry in Saxony between 2000 and 2014 were included in this registry study. Characteristics such as age, disease location and extra-intestinal manifestations at diagnosis were accessed. The severity level of the disease at diagnosis as well as at follow-up were analysed by PCDAI index. Patients were divided into 3 groups according to length of follow-up: 1–3 years, 4–6 years and 7–9 years after diagnosis. A logistic regression model was conducted to examine which baseline parameters are associated with disease progression.

Results
There were 338 children and adolescents with CD included in this registry study. At diagnosis, the median age of patients was 12.0 (0.7–14.9), 61.5% (n = 208) of the patients were male. The most common disease location observed in pediatric CD patients was the L3 (55%, n = 176). Patients aged 10–14 years were significantly more likely to present an L2 than patients aged 0–4 years (80.3%, n = 53 vs. 19.7%, n = 13, p = 0.01). During the follow-up, data from 71.3% (n = 241) othe patients were available. Disease activity measured by PCDAI decreased in 47.7% (n = 115) of the patients, 40.7% (n = 98) of the patients were stable and increased in 11.6% (n = 28) of the patients. Patients with intermediate/severe disease at onset were more likely to have an active disease at the end of follow up, too (p = 0.00). Logistic regression analysis of the initial characteristics showed that the age at diagnosis, gender, initial location and initial extra-intestinal manifestation are not associated with the progression of the disease (p>0.05). Furthermore, drug treatment options could be identified from our data, which are associated with benefits for a milder course or remission.

Conclusion
From 2000 to 2014, the health status of most pediatric patients with CD had improved or remained stable. Initial characteristics including age at diagnosis, initial localization and initial extra-intestinal manifestation are not associated with the progression of the disease, only the initial activity by PCDAI.
LINC01117 inhibits invasion and migration of lung adenocarcinoma through influencing EMT process
Authors: Liu Linjun , Ren Wenjia , Du Licheng , Xu Ke , Zhou Yubai 
Published: June 2023

Background
Studying the mechanism of action of LncRNAs in lung adenocarcinoma (LUAD) is of great importance for an in-depth understanding of the molecular mechanism of lung adeno carcinogenesis and development.

Objective
The aim is to identify a long non-coding RNA LINC01117 that is specifically and highly expressed in LUAD cells and to investigate its biological functions and molecular mechanisms in LUAD cells, providing a new potential target for targeting LUAD therapy.

Methods
This study used publicly available data downloaded from The Cancer Genome Atlas (TCGA) database. Construction of siRNA and overexpression plasmid-packed lentiviral constructs were used to knock down and increase the expression of LINC01117 in LUAD cells. The effect of LINC01117 on LUAD cell migration and invasion was verified by scratch assays and Transwell assays. Western blot assays were performed to verify the effect of knocking down LINC01117 expression on key proteins of the EMT process. The effect of overexpression and knockdown LINC01117 expression on key proteins of the EMT process and the nuclear and cytoplasmic distribution of YAP1, a key effector molecule of the Hippo pathway, was verified by Western blot assays.

Results
LINC01117 expression was upregulated in LUAD tissues and cell lines. Clinical correlation and prognostic analyses showed that LINC01117 was associated with poorer clinical features (staging and N classification) and poorer prognosis and could be analyzed as an independent prognostic factor. Cell migration and invasion were significantly inhibited in the knockdown group compared to the control group; in contrast, cell migration and invasion were promoted in the overexpression group. Overexpression of LINC01117 resulted in down-regulation of E-cadherin expression and increased expression levels of N-cadherin, vimentin, ZEB1, snail and slug; in contrast, knockdown of LINC01117 appeared to have the opposite effect. Furthermore, knockdown of LINC01117 increased the enrichment of YAP1 protein in the cytoplasm and reduced its level in the nucleus; overexpression of LINC01117 produced the opposite intracellular distribution results.

Conclusions
LINC01117 was highly expressed in LUAD, and knockdown of LINC01117 significantly inhibited the migration and invasion of LUAD cells, while overexpression of LINC01117 significantly promoted the migration and invasion of LUAD cells, and affected the EMT process, and was able to alter the distribution of YAP1 in the nucleus and cytoplasm. This suggests that LINC01117 may regulate the activity of the Hippo pathway by altering the nuclear and cytoplasmic distribution of YAP1, which in turn induces the EMT process in lung adenocarcinoma cells and thus exerts a pro-cancer effect. It suggests that LINC01117 may play a key role in the occurrence and development of LUAD.
Identifying important factors for successful surgery in patients with lateral temporal lobe epilepsy
Authors: Kim Jae Rim , Jo Hyunjin , Park Boram , Park Yu Hyun , Chung Yeon Hak , Shon Young-Min , Seo Dae-Won , Hong Seung Bong , Hong Seung-Chyul , Seo Sang Won , Joo Eun Yeon 
Published: June 2023

ObjectiveLateral temporal lobe epilepsy (LTLE) has been diagnosed in only a small number of patients; therefore, its surgical outcome is not as well-known as that of mesial temporal lobe epilepsy. We aimed to evaluate the long-term (5 years) and short-term (2 years) surgical outcomes and identify possible prognostic factors in patients with LTLE.MethodsThis retrospective cohort study was conducted between January 1995 and December 2018 among patients who underwent resective surgery in a university-affiliated hospital. Patients were classified as LTLE if ictal onset zone was in lateral temporal area. Surgical outcomes were evaluated at 2 and 5 years. We subdivided based on outcomes and compared clinical and neuroimaging data including cortical thickness between two groups.ResultsSixty-four patients were included in the study. The mean follow-up duration after the surgery was 8.4 years. Five years after surgery, 45 of the 63 (71.4%) patients achieved seizure freedom. Clinically and statistically significant prognostic factors for postsurgical outcomes were the duration of epilepsy before surgery and focal cortical dysplasia on postoperative histopathology at the 5-year follow-up. Optimal cut-off point for epilepsy duration was eight years after the seizure onset (odds ratio 4.375,p-value = 0.0214). Furthermore, we propose a model for predicting seizure outcomes 5 years after surgery using the receiver operating characteristic curve and nomogram (area under the curve = 0.733; 95% confidence interval, 0.588–0.879). Cortical thinning was observed in ipsilateral cingulate gyrus and contralateral parietal lobe in poor surgical group compared to good surgical group (p-value < 0.01, uncorrected).ConclusionsThe identified predictors of unfavorable surgical outcomes may help in selecting optimal candidates and identifying the optimal timing for surgery among patients with LTLE. Additionally, cortical thinning was more extensive in the poor surgical group.
A review of polyunsaturated fatty acids (PUFA) of marine zoosporic microorganisms and their commercialization
Authors: Saikia Diganta Kumar , Chikkaputtaiah Channakeshavaiah , Velmurugan Natarajan 
Published: June 2023

Abstract
Long-chain polyunsaturated fatty acids (LC-PUFA) are nutritionally and pharmacologically well-recognized beneficial compounds widely used as nutrient supplements for various applications. As the human body cannot accomplish de novo synthesis of PUFA, we depend on exogenous bioresources for the supply of these essential PUFA for day-to-day activities. The PUFA global market is expected to reach about US$ 9.7 billion by 2032. The recent drop in natural fish catch and global climate change severely hamper the global PUFA supply chain. As a sustainable, promising resource, marine zoosporic microorganisms are considered to be safe and alternative primary producers of beneficial PUFAs for direct and indirect human consumption. However, by considering the limitations associated with strain efficiency, final product yield and production cost, more viable low-cost production strategies and establishment of highly efficient, stable, high production cell lines specific for marine zoosporic microbes are essential to meet global PUFA market demand. The exploration of the latest techniques for research and development could shape the dynamics better for the global market for marine zoosporic organism-based PUFA products. Therefore, this review first summarizes low-cost production and strain improvement strategies, and later highlights the advantages and commercial prospects for marine zoosporic microbe-derived PUFA.
Identification and tracing of radionuclides in low- and medium-activity liquid radwaste sources of G.A. Siwabessy reactor
Authors: Sriyono Sriyono , Saprudin Deden , Rafi Mohamad , Sunaryo Geni R. , Luhur Nugraha , Muslimu Fahmi A. 
Published: June 2023

Abstract
The liquid radioactive waste generated by the G.A. Siwabessy reactor (RSG-GAS) is categorized into low-activity liquid radwaste (LALR) and medium-activity liquid radwaste (MALR). The radionuclide content of both LALR and MALR can use as an indicator of the structural integrity of the reactor’s systems, structures, and components (SSC). To evaluate the degradation of the reactor SSC, the radionuclide species were identified, and their activities were measured using gamma spectroscopy. Based on the identified radionuclides, the process of their formation can be traced. The radionuclides identified in LALR were 24Na, 51Cr, 59Fe, 60Co, 65Zn, and 124Sb, while the radionuclides in MALR were 24Na, 51Cr, 58Co, 59Fe, 60Co, 65Ni, 65Zn, 89Kr, 90Kr, 109Cd, 131I, 132I, 140Ba, 137Cs, 146Ce, and several others. The radionuclides found can be classified into corrosion product activation (60Co, 65Zn, 51Cr, 59Fe, 24Na, 65Ni), topaz impurities activation (51Cr, 59Fe, 60Co, 65Zn), fission product (90Kr, 140Ba, 131I, 137Cs, etc.), and demineralized water impurities activation (51Cr, 59Fe, 65Zn, 60Co, etc.). After comparing the activity value of each radionuclide with the limit value in the safety analysis report document, we can conclude that the activity of each one is below the required level. It can infer that the structural integrity of reactor SSC is still well maintain. During routine monitoring, the radionuclide content in the primary coolant fluctuates depending on the reactor load. The concentration of radionuclides detected varies when a large or small number of research samples are loaded onto the core. Nevertheless, their activities remain within the required safety limits.