bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hábitos alimentarios, actividad física y estilos de vida en adolescentes estudiantes de la Licenciatura en Enfermería.
Authors: Solis Gómez Celia del Carmen , Hernández de la Cruz Amelia , Villarreal Luna Sandra del Carmen , Córdova Soberano Beatriz , Suárez Mendoza Evelyn Naomy 
Published: February 2023

Introducción: La adolescencia es el periodo comprendido entre los diez a los 19 años, en el cual suceden diversos cambios, tanto físicos, emocionales, familiares y sociales, considerándose como una etapa de adquisición de hábitos alimentarios y del estilo de vida (Barriguete et al., 2017).
Objetivo: Identificar los hábitos alimentarios, actividad física y estilos de vida en adolescentes estudiantes de la Licenciatura en Enfermería.
Método: estudio de tipo transversal, descriptivo, en 105 estudiantes de primer año de la LE, recopilando información acerca de hábitos alimentarios (Gallegos, 2019), actividad física (Cuestionario de actividad física IPAQ, 1996) y estilos de vida (Fantastic UM, 2000). Los datos se analizaron con el software estadístico SPSS 21.
Resultados: El 78.5% de la muestra estuvo constituida por mujeres y el 21.5% por hombres y el municipio de procedencia predominante fue el centro con 52%. Los hábitos alimentarios se categorizaron en un 36.2% como mala alimentación, el 35.2% como alimentación regular, el 23.8% muy mala alimentación y el 4.8% como buena alimentación. La actividad física por su parte mostro un 52.4% del nivel de actividad fisca vigorosa, mientras que un 27.6% realiza actividad física moderada y el 20% un nivel de actividad física baja. Y finalmente el cuestionario Fantastic reporto un 48.6% de estilo de vida adecuado, estas bien y el 51.4 % buen trabajo, estás en el camino correcto.
Conclusiones: Los hábitos alimentarios, la actividad física y el estilo de vida, cobran especial importancia dadas las condiciones sanitarias actuales, para mantener las funciones fisiológicas y también podrían ser beneficiosas para reducir las consecuencias mentales y físicas del aislamiento social (Jiménez, Carbonell y Lavie, 2020).
Letak Strategi dan Pengembangan Potensi Sumber Daya Alam di Kalimantan Selatan
Authors: Normelani Ellyn , Putri Anisa , Efendi Muhammad , Danarto Wisnu Putra 
Published: February 2023

Letak geografis Kalimantan Selatan sangat strategis, tidak hanya dari kondisi alam yang mempengaruhi kehidupan makhluk hidup, tetapi lintas benua dan samudera juga ikut berpengaruh terhadap kebudayaan yang banyak dipengaruhi oleh kebudayaan asing. Kalimantan Selatan memiliki potensi besar di bidang pertanian, perkebunan, pertambangan, industri, perekonomian, pariwisata, dan bidang lainnya. Tujuan penelitian ini untuk menganalisis dan mengetahui letak strategis Kalimantan Selatan yang memiliki potensi dan sektor unggulan serta langkah pemerintah dalam mengembangkan potensi alam maupun non alam di bidang sektor tersebut. Penelitian ini menggunakan metode kualitatif deskriptif. Bidang ekonomi, memegang peran penting dalam perdagangan. Kalimantan Selatan memiliki sumber daya pesona alam, budaya dan kuliner yang ada diberbagai wilayah yang belum banyak diketahui oleh masyarakat dan belum dikelola dengan baik oleh pemerintah. Budaya-budaya yang dimiliki oleh Kalimantan Selatan sebagiannya sudah ada yang terkenal dan mendunia seperti budaya Banjar, budaya Dayak Meratus dan batik sasirangan. Kalimantan Selatan memiliki potensi sumber daya alam berupa batubara, mineral, emas, intan, permata, minyak gasa dan bumi, kelapa sawit, karet dan lainnya. Oleh karena itu potensi sumber daya alam yang ada di Kalimantan Selatan harus dikelola, dikembangkan dan di manfaatkan dengan baik sehingga dapat meningkatkan perekonomian daerah
Breakage of a Pituitary Rongeur Tip: An Unforeseen Complication of Lumbar Microdiscectomy
Authors: Ramachandran Karthik , Meena Jalaj , Anand K. S. Sri Vijay , Shetty Ajoy Prasad , Shanmuganathan Rajasekaran 
Published: February 2023

Case:
A 46-year-old man with left leg radiculopathy due to a left L4-5 disc extrusion had a lumbar microdiscectomy that was complicated by the pituitary rongeur tip breaking in the L4-5 disc space. The rongeur tip was successfully retrieved by widening the entry access without damaging the adjoining facet and utilizing a blunt nerve hook and probe dissector.

Conclusion:
Breakage of the pituitary rongeur tip is an unforeseen complication of lumbar microdiscectomy. Surgeons should be aware of this potential complication, ideally confirm the rongeur is intact prior to wound coverage, and understand the risks versus benefits of attempting to retrieve a broken rongeur tip.
Protocol for Alberta Societal Health Integration Program (ABSHIP): Community- based Complementary &amp; Alternative Medicine (CAM) Services Model for Social Recovery and Improve Economic Participation
Authors: Lu Mingshan , Sharmin Sumaiya , Cong Yingying , Li Yang , Tao Yong , Xia Meng , Xia Xin , Wang Helen , Xu Ning , Yang Gongliang , Xiao Yun , Peng Laura , Xu Bentong 
Published: February 2023

Abstract

Background

Mental health problems and chronic health conditions cause significant productivity loss in the workplace. Chronic pain and mental health care needs in Canada that existed before COVID-19 remain unmet and have been exacerbated by the pandemic. The Alberta Societal Health Integration Program (ABSHIP) proposes an innovative community-based model in which Complementary and Alternative Medicine (CAM) services are provided to help achieve social recovery and improve economic participation.

Methods

Participants will receive CAM treatment in two modes: a minimum of two acupuncture treatment sessions per week for up to a total of 12 treatments, and voluntary Qigong exercise. The study will recruit 150 participants between the ages of 14 and 55 who are suffering from pain or mental health issues that are causing severe productivity loss. Primary outcome indicators are productivity (WPAI), pain (BPI), quality of sleep (PSQI), depression (PHQ-9), anxiety (GAD-7), anger (DAR-5), quality of life (EQ-5D-5L) and substance use (DAST-10 & CAGE). Secondary outcome indicators include general health care utilization, which will be measured by patients’ self-reported inpatient, outpatient, emergency department, and prescription drug utilization. Data will be collected at baseline (before treatment) and after the sixth and twelfth session (post-treatment) to measure short-term outcomes of the study. To understand the long-term impact of ABSHIP, participants will be invited to take the same survey three and six months after completing the program.

Discussion

ABSHIP is a first-of-its-kind study that provides CAM integrated interventions to enhance pain management, as well as protecting and fostering psychosocial well-being and resilience in children, adolescents, and seniors. The successful completion of the project will result in cost savings as well as significant evidence to aid instrument policy in the short and long run.

Trial Registration

This interventional study involving human participants, has been approved by the University of Calgary (UofC) Conjoint Health Research Ethics Board (CHREB) (ethics ID: REB 21-2050).
Brain corticogenesis and cholesterol homeostasis promotes SARS-CoV-2 infection and replication
Authors: Moon Byoung-San , Ahn Dae-Gyun , Park Jieun , Mai Thi Quynh Nhu , Batjargal Ulziituya , Hong Hyowon , Yoon Sae-Bom , Lee Sunhee , Yoon Gun Young , Kim Chonsaeng , Ku Keun Bon , Nam Hye Jin , Kwak Ihn-Sil , Kim Seong-Jun , Cho Heeyeong 
Published: February 2023

Abstract
Although the neuroinvasiveness of SARS-CoV-2 has been extensively studied, the correlation between virus infectivity and brain maturation remained unclear. Here, using human-induced pluripotent stem cells-derived three-dimensional cerebral organoids (CBOs), we present the first quantitative data for long-term kinetics of SARS-CoV-2 propagation in brain for 20 days post-infection. We showed that mature brains are more susceptible to SARS-CoV-2 than immature counterparts, evident from increased viral replication rate and higher TUNEL + cells proportion. Transcriptome profiling identified enhancement of corticogenesis and gliogenesis and indicated enrichments in translation machinery- and lipid metabolism-associated genes in mature brain, suggesting the major factors conferring the robust infectivity of SARS-CoV-2. The role of cholesterol in promoting viral replication was confirmed by the reduced number of infected cells in lipid lowering-drugs condition. Together, this study highlights that permissiveness of the brains to SARS-CoV-2 is greatly enhanced with their maturation and suggests cholesterol as a new target for suppressing viral replication.
Study on form optimization of open-pit mine slope based on section and spatial form effect
Authors: Jia Lan , Wang Jiaqi , Cai Xueting , Fang Linhao , Wang Dong 
Published: February 2023

Abstract
Reasonable design of the slope form of mining field is an important prerequisite for optimizing open-pit mining boundary, ensuring safe production and improving economic benefits of open-pit mines. Taking an open-pit mine in Thar coalfield of Pakistan as the research background. Based on the section form effect of slope stability and the occurrence characteristics of coal seam and weak layer, the section form of slope was optimized step by step from two-dimensional angle by using the rigid body limit equilibrium method. The three-dimensional numerical simulation method was used to revealed the influence of slope spatial geometry on slope stability, that based on the three-dimensional spatial effect of slope stability. At the same time, the three-dimensional numerical simulation method was used to optimize the spatial form of the slope, thus revealed the evolution mechanism of slope instability. By comparing the optimized slope form with the preliminary design and the slope form of the the straight slope with equal flat plate, the economic benefits were further analyzed. The results showed that under the premise of meeting the safety reserve coefficient, compared with the preliminary design and the design of equal plate. The slope angle of the optimized section form was increased by 1 ° and 3 ° respectively, and the coal resource recovery was increased by 332m2 and 1790m2 respectively, and the economic benefits were $ 18065859 and $ 54408251 respectively. And the slope angle of the optimized spatial form was increased by 3 ° and 5 ° respectively, and the coal resource recovery was increased by 1188m2 and 2726m2 respectively, and the economic benefits were $ 72082808 and $ 108417368 respectively.
In major joint diseases the human synovium retains its potential to form repair cartilage
Authors: Hunziker Ernst B. , Shintani Nahoko , Lippuner Kurt , Vögelin Esther , Keel Marius JB 
Published: February 2023

Abstract

The inner surface layer of human joints, the synovium, is a source of stem cells for the repair of articular cartilage defects. We investigated the potential of the normal human synovium to form novel cartilage and compared its chondrogenic capacity with that of two patient groups suffering from major joint diseases: young adults with femoro-acetabular impingement syndromes of the hip (FAI), and elderly individuals with osteoarthritic degeneration of the knee (OA). Synovial membrane explants of these three donor groups were inducedin vitroto undergo chondrogenesis by growth factors: bone morphogenetic protein-2 (BMP-2) alone, transforming growth factor-ß1 (TGF-ß1) alone, or a combination of these two. Quantitative evaluations of the newly formed cartilages were performed respecting their gene activities, as well as the histochemical, immunhistochemical, morphological and histomorphometrical characteristics. Formation of adult articular-like cartilage was induced by the BMP-2/TGF-ß1 combination within all three groups, and was confirmed by adequate gene-expression levels of the anabolic chondrogenic markers; the levels of the catabolic markers remained low. Our data reveal that the chondrogenic potential of the normal human synovium remains uncompromised, both in FAI and OA. The potential of synovium-based clinical repair of joint cartilage may thus not be impaired by age-related joint pathologies.
Stochastic finite-fault modelling of Ms 6.8 Luding earthquake in 2022 and seismic hazard scenario of Moxi Fault, Southwest China
Authors: Wang Tianjia , Xie Xu , Shen Yonggang , Weng Weipeng 
Published: February 2023

Abstract

The establishment of ground motion model is a crucial component of seismic hazard analysis, and the numerical simulation technology of ground motion is widely used in regions with insufficient earthquake records. Based on the stochastic finite-fault method, the present work performed the scenario-based seismic hazard analysis of Moxi fault. Considering the variety of site amplification caused by complex terrain, genetic algorithm was conducted to identify the site amplification. Through the simulation of the Ms 6.8 Luding earthquake in 2022, it was found that the correction of site amplification effectively reduced the model deviation, and made the simulated 5%-damped spectral acceleration (SA) in good agreement with the observation. After that, the ground motion of the Mw 7.1 scenario earthquake was synthesized using the calibrated input parameters and hybrid source model, so as to effectively reflect the uncertainty of source parameters. The scenario earthquake was discussed through: 1) sensitivity analysis of stress drop and upper-edge buried depth; 2) identification of the probability distribution of SA at 0.8 s, which represented the dynamic characteristics of engineering structures; 3) generation of seismic hazard map using ground motion intensity index. The prediction of the scenario earthquake provided a basis for earthquake disaster loss evaluation and seismic fortification of engineering structures.
Machine Learning approach for Drug-Target affinity prediction in Computer Aided Drug Design
Authors: Dani Ninad Janardan , Deshmukh Nilesh K. , Kadam Purushottam A. , Nayak Sunil Kashibarao 
Published: February 2023

Abstract
Since the COVID-19 outbreak in early 2020 and till today, the medicinal drug industry is becoming more in demand and also utilizing new research and development tools to create and identify new drugs for various diseases. One of the famous approaches in Artificial Intelligence which is used for computer aided drug design is Machine Learning. In this paper, the machine learning approach for drug-target interaction (DTI), which is the part in drug design, is discussed with practical and algorithmic implementation. Datasets such as Kinase Inhibitor Bioactivity (KIBA) and Davis are used which are popular for the purpose. The use of techniques like Convolutional Neural Networks (CNNs) for the 1- dimensional inputs like protein sequences and SMILES (Simplified Molecular Input-Line Entry System) to calculate binding affinity and drug target interaction (DTI) is also discussed here.
A whole-exome analysis of non-syndromic hearing loss patients from India reveals a wide spectrum of known and novel mutations
Authors: Chakraborty Sudipta , Mitra Sukanya , Ghosh Arnab , Kumar Krishna , Sanga Shamita , Dutta Atanu Kumar , Mukherjee Suchandra , Biswas Nidhan Kumar , Chakrabarti Saikat , Acharya Moulinath 
Published: February 2023

Abstract
Background
Non-syndromic hearing loss (NSHL) is characterized by congenital mild-to-profound sensorineural hearing impairment. It affects 1 in 1000 neonates in India. While we have a large genetically deaf population in India, our knowledge about the specific causes behind the disorder is almost non-existent. We carried out clinical audiological characterization in a cohort of 43 NSHL patients from India and subsequently performed whole exome seqencing (WES) to create a high-resolution genomic architecture behind congenital hearing loss. Furthermore, molecular dynamics simulations (MDS) and in silico homology modeling were conducted for some novel and missense variants. Moreover, we investigated the genotype-phenotype relationship to reach a final diagnosis for NSHL.
Results
A total of 28 rare and deleterious mutations were identified in 21 genes previously reported based on the hereditary hearing loss database. We could accurately diagnose 51% of the patients (n = 22/43) in our NSHL cohort. The presence of pathogenic and likely pathogenic mutations was confirmed by Sanger sequencing. Additionally, in silico homology modelling and MDS of mutations in GJB2, SLC26A4, GPSM2, TMPRSS3, CIB2, and TSPEAR revealed that the stability of the mutant proteins was altered compared to their wild-type, suggesting their potential pathogenic role.
Conclusion
The WES findings would help create a strong knowledge base for deafness genetics in the Indian population, which will aid in high-quality genetic care for families with this disability that was challenging using traditional diagnostic methods. The therapeutic use of this WES finding will help guide clinical care and genetic counseling for individuals with NSHL.
Invitro efficacy of green synthesized silver nanoconjugates of Valeriana wallichii methanolic root extract against MDR strain of Acinetobacter baumannii
Authors: Kumar Manish , Agarwal Mohini , Anguluri N.V. Lakshmi Kavya , Mane Pratibha , Sinha O. P. , Bala Kumud 
Published: February 2023

Abstract

Background
Antimicrobial resistance is peaking up all over the world and requires immediate attention. In quest of finding a sustainable solution to the present threat of future epidemics which is going to be caused by Acinetobacter baumannii (A. baumannii) as per the WHO report (2020), this study has been used to pave a path for finding an herbal solution to it. The novelty of this study is that Valeriana wallichii (V. wallichii) has been analyzed for its methanolic extract/nano-conjugate against A baumannii.
Results
HPLC of the extract has shown the presence of polyphenols- Quercitin, Rutin, and Tannic acid in high concentration. This fraction on nano-conjugation with silver has shown its equivalence to tetracycline antibiotics in restricting the growth of A. baumannii. Further, insilico studies taking crucial death receptors (Amp C, Fab1, RstA, LpxA, Aspartokinase, and shikimate dehydrogenase) of A. baumannii have shown binding energy ranging from − 11.6 to -13.3 kcal/mol for Tannic acid and close to this for Rutin and Linalool. It signifies that the fraction is potent enough to be a potential drug candidate for restricting this bacterium. The results were amazing when V. wallichii silver nanoconjugate (Vw-AgNCs), size range 1-200nm validated by DLS, AFM, and SEM-EDX on green synthesis has many times substantially enhanced restriction of A. baumannii as compared to only extract of V. wallichii. Keeping in view, its application to mankind, the cytotoxicity of the extract was evaluated on the human Fibroblast cell line (L929), showing an LC50 value of 368ug/ml. Many types of research have shown the time-dependent cytotoxicity of antibiotics as low as 5-50ug/ml providing us with a huge therapeutic window for the Vw-AgNCs.
Conclusion
Vw-AgNCs exhibited strong antimicrobial activity than the only extract and chemically synthesized nanoparticles so they can be a potential antimicrobial agent against A. baumannii in the future.
Application of Optical Coherence Tomography Angiography in True and Pseudo Optic Disc Swelling
Authors: Aghdam Kaveh Abri , Aghajani Ali , Zand Amin , Chaibakhsh Samira , Ijadi Fatemeh Zahra , Falavarjani Khalil Ghasemi 
Published: February 2023

Abstract
We assessed the optic disc microvasculature in healthy subjects and patients with optic nerve head drusen (ONHD), active papilledema, and acute non-arteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography angiography (OCTA). Sixteen eyes with ONHD, 31 eyes with active papilledema, 16 eyes with acute NAION, and 32 healthy eyes were included in this prospective and comparative case series. Peripapillary retinal nerve fiber layer (RNFL) thickness and optic disc vasculature maps were recorded by OCTA. Average RNFL thicknesses were greater in the eyes with ONHD, papilledema, and NAION than in control eyes (all Ps < 0.001), but this parameter did not differ among patient groups. In comparison to healthy eyes, the peripapillary vessel density in the ONHD group was not lower (P= 1.000), in contrast to the papilledema and NAION groups (P = 0.008, and P < 0.001, respectively). The only difference between eyes with papilledema and ONHD was lower peripapillary vessel density in the papilledema group (P = 0.018). All vessel density values were lower in the eyes with NAION in comparison to the ONHD (all Ps ≤ 0.002). In addition, in the eyes with NAION, the inside disc vessel density was lower than papilledema (P< 0.001). Peripapillary vascular density is affected during the course of ONHD, papilledema, and NAION. Despite the observed decrease in the vessel density values in true disc edema, further studies are needed to evaluate the application of OCTA for differentiating true from pseudo optic disc edema.
Effect of Confinement on Recirculation Structures in Isothermal Coaxial Swirling Jet
Authors: Santhosh R. , Pattanshetti Arun , Chaturvedi Shivansh 
Published: February 2023

Abstract
In this work, an experimental and numerical investigation of effect of two confinement ratios (CR=1.81, and 2.7) on two different recirculation zones (RZs) viz., prevortex breakdown bubble (PVB) and central toroidal recirculation zone (CTRZ) observed in coaxial swirling jet in isothermal/non-reacting conditions is presented. As a part of experimental study 2-D laser Doppler velocimetry (LDV) has been used to acquire mean axial velocity values at different points within the non-reacting/isothermal flow field. 3D unsteady RANS simulations are carried out to evaluate the performance of different turbulent models in predicting the two types of RZs in confined condition. Radial profiles of mean axial velocity and extent (dimensions) of recirculation zones (RZs) obtained experimentally are used as parameters to compare the numerical results consequently to evaluate suitable turbulent models in simulating two types RZs. Finally, the numerical results obtained by employing best suitable turbulent model are used to gain more physical insights into the flow field of confined coaxial swirling jets. Results showed that flow confinement has a significant effect on the two types RZs studied. Furthermore, the effect of confinement ratio CR=2.7 is found more similar as that of unconfined case whereas, the wall/confinement effect is strongly witnessed in CR = 1.81 case for both PVB and CTRZ flow states.