bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endometriosis as very common cause of chronic pelvic pain – overview of actual knowledge
Authors: Miszczyk Karolina , Gonet Malwina , Kania Agata , Lazar Michał , Maj Patrycja , Maternia Jakub , Mozer Piotr , Sergiel Natalia , Serwik-Trandasir Aleksandra , Włodarczyk-Cybulska Karolina 
Published: August 2023

Introduction and purpose of the study: Endometriosis is a prevalent condition that affects women in their reproductive years. Diagnosing the condition and determining its manifestations can be complex and uncertain, as they vary among individuals. The symptoms of endometriosis have a detrimental impact on the overall quality of life for patients, leading to decreased well-being, limitations in physical activity, and impaired social functioning. The available treatments for endometriosis are determined based on the primary symptom (chronic pelvic pain or infertility) and are primarily focused on surgical interventions, hormonal therapies, and analgesic medications. These treatments often come with numerous side effects and rarely offer long-term relief. In this review, we provide a comprehensive overview of the current knowledge regarding endometrosis, including its pathophysiology, diagnostic methods, and the existing treatment options.

Materials and methods: The analysis relied on examining materials obtained from both the "PubMed" database and books. The search was performed using the keywords: "endometrosis diagnosis", "endometrosis therapy", "dysmenorrhea", "combined oral contraceptive", "laparoscopy".

Summary: Endometriosis poses a significant health concern due to its correlation with compromised daily functioning and infertility. Appropriate diagnostic and therapeutic management of endometriosis contributes to a significant improvement in the wellbeing of patients, including a reduction in pain and improved ability to function both physically and socially. Conservative treatment consists of hormonal therapy, which regulates the menstrual cycle, reduces the severity of pain symptoms and inhibits the development of endometrial foci outside the uterus. In situations of advanced endometriosis, pharmacological treatments may not be sufficient and surgical therapy is required.
Exploring the link between green energy, CO2 emissions, exchange rate and economic growth: Perspective from emerging South Asian countries
Authors: Rahman Mohammad Rifat , Rahman Md. Mufidur , Akter Roksana 
Published: August 2023

This paper investigates the nexus between renewable energy use, CO2 emissions, exchange rate, and economic development within emerging South Asian nations, namely Bangladesh, India, Pakistan, and Sri Lanka, employing the Autoregressive Distributed Lag (ARDL) framework. It examines annual data spanning from 1990 to 2019, examining key indicators of renewable energy consumption, CO2 emissions, exchange rate, and economic development. The ARDL bounds test results demonstrate the existence of co-integration among the variables in the long run. The empirical result finds that the renewable energy consumption, CO2 emissions, and exchange rate have a significant impact on economic growth in Bangladesh, Pakistan, and Sri Lanka in the long run. In India no significant relationship found in the long run. In short run assessment, Bangladesh, India, and Sri Lanka also found same relationship with economic growth and renewable energy consumption, CO2 emissions, and exchange rate. Interestingly, In Pakistan no significant relationship has found in short run estimation analysis. Furthermore, study tried to determine the causality direction by using the Toda Yamamoto granger causality approach, which reveals bidirectional causation between exchange rate and CO2 emission in India. In Pakistan, study also found bi-directional causality among the variables renewable energy consumption, CO2 emissions, and economic growth. Finally, this paper emphasizes developing the policy as well as making a concrete decision regarding the renewable energy consumption, CO2 emissions, exchange rate, and economic development for ensuring sustainable economic growth in South Asian region. Future research could extend this work by including different dimensional data, additional countries, or using alternative or supplementary modeling techniques.
Comparación de la métrica Sigma calculada con tres métodos de estimación del sesgo en 33 magnitudes químicas y 26 de inmunoensayo
Authors: Ercan Şerif 
Published: August 2023

Resumen

Objetivos
Aunque la métrica Sigma se puede calcular mediante una sencilla ecuación, la diversidad de fuentes de las que se extraen los elementos de la ecuación pueden arrojar diferentes valores Sigma. El objetivo de este estudio era investigar la importancia de las distintas estrategias de estimación del sesgo para el cálculo de la métrica Sigma.

Métodos
Se calculó la métrica Sigma de 33 magnitudes químicas y 26 magnitudes de inmunoensayo en un analizador Roche Cobas 6,000. El sesgo se calculó mediante tres métodos: a) calculando la media del sesgo mensual obtenida en los estudios de control de calidad externo (EQA, por sus siglas en inglés); 2) calculando los valores de sesgo mediante una ecuación de regresión a partir de datos obtenidos del EQA; y 3) calculando la media de los valores de sesgo mensual de los eventos de control de calidad internos (IQC, por sus siglas en inglés). Se realizó una métrica Sigma para cada uno de los dos niveles de muestras de IQC empleando tres métodos para calcular el sesgo. Los valores Sigma obtenidos se clasificaron en cinco categorías, en función de las reglas Sigma de Westgard, siendo ≥6, <6 y ≥5, <5 y ≥4, <4 y ≥3, y <3.

Resultados
Al clasificar la métrica Sigma, calculada aplicando tres métodos de estimación del sesgo para cada magnitud, se observó que 16 magnitudes químicas en los niveles 1 y 2 de IQC fueron clasificadas en categorías Sigma diferentes por al menos uno de los métodos de estimación de la desviación. Del mismo modo, dependiendo del método de estimación del sesgo empleado, se clasificaba en diferentes categorías a 12 magnitudes de inmunoensayo con niveles 1 y 2 de IQC.

Conclusiones
La métrica Sigma puede variar dependiendo del método empleado para calcular el sesgo, lo cual debe ser tenido en cuenta a la hora de evaluar el rendimiento analítico o programar eventos de IQC aplicando el método Seis Sigma.
Rodent models for mood disorders – understanding molecular changes by investigating social behavior
Authors: Reinhardt Patrick R. , Theis Candy D. C. , Juckel Georg , Freund Nadja 
Published: August 2023

Abstract
Mood disorders, including depressive and bipolar disorders, are the group of psychiatric disorders with the highest prevalence and disease burden. However, their pathophysiology remains poorly understood. Animal models are an extremely useful tool for the investigation of molecular mechanisms underlying these disorders. For psychiatric symptom assessment in animals, a meaningful behavioral phenotype is needed. Social behaviors constitute naturally occurring complex behaviors in rodents and can therefore serve as such a phenotype, contributing to insights into disorder related molecular changes. In this narrative review, we give a fundamental overview of social behaviors in laboratory rodents, as well as their underlying neuronal mechanisms and their assessment. Relevant behavioral and molecular changes in models for mood disorders are presented and an outlook on promising future directions is given.
Effects of random selection tests on second language vocabulary learning: a comparison with cumulative tests
Authors: Kanayama Kohei , Iwata Akira , Kasahara Kiwamu 
Published: August 2023

Abstract
Cumulative tests (CTs) require learners to recall previously learned words. The scope of the tested words gradually increases with increased study sessions. A potential limitation of CTs is that less learning may occur for words introduced later than earlier. This study proposes random selection tests (RSTs), which may compensate for this problem. We randomly selected the tested words from all target words, such that learners can review all words in a balanced manner. To investigate whether RSTs compensate for CT limitations, the study randomly assigned 69 Japanese learners of English to the RST or CT group. They were given 45 Japanese and English word pairs and weekly small tests across three weeks. The CT group recalled 15 words per small test, in which the scope of the tested words increased (15 → 30 → 45 words). Alternatively, the RST group recalled 15 words, which were randomly selected from 45 words, per small test. The posttest revealed that the RST group compensated for the limitation and retained the second and last 15 words better than did the CT group. The findings suggest that RSTs enable L2 learners to study all words in a balanced manner.
POD-ROMs for incompressible flows including snapshots of the temporal derivative of the full order solution: Error bounds for the pressure
Authors: García-Archilla Bosco , John Volker , Katz Sarah , Novo Julia 
Published: August 2023

Abstract
Reduced order methods (ROMs) for the incompressible Navier–Stokes equations, based on proper orthogonal decomposition (POD), are studied that include snapshots which approach the temporal derivative of the velocity from a full order mixed finite element method (FOM). In addition, the set of snapshots contains the mean velocity of the FOM. Both the FOM and the POD-ROM are equipped with a grad-div stabilization. A velocity error analysis for this method can be found already in the literature. The present paper studies two different procedures to compute approximations to the pressure and proves error bounds for the pressure that are independent of inverse powers of the viscosity. Numerical studies support the analytic results and compare both methods.
Molecular characterization of methicilin-resistant Staphylococcus aureus strain BM85 isolated from a Vietnamese patient with bloodstream infection
Authors: Dinh Phuc Hoang , Thanh Tam Tran Thi , Thu Hang Le Thi , Kieu Oanh Nguyen Thi , Hai Long Vu Dang , Duy Hung Kieu , Bañuls Anne-Laure , Quang Huy Nguyen 
Published: August 2023

Methicillin-resistant Staphylococcus aureus (MRSA) is a threat to global health due to its resistance to β-lactam antibiotics and many other antibiotic classes developed via both intrinsic and acquired mechanisms. In this study, molecular characteristics related to antibiotic resistance of MRSA strain BM85 were investigated by whole-genome sequencing of a sample isolated from a patient with bloodstream infection at Bach Mai Hospital, Vietnam. Antibiotic susceptibility testing was also performed to determine the correlation between the presence of antibiotic-resistant genes and resistance phenotypes. Genomic analyses showed that the MRSA strain BM85 belonged to the major community-acquired (CA)-MRSA lineage ST59 originating from Taiwan. The strain harbored Staphylococcal Cassette Chromosome mec (SCCmec) type Vb (5C2&5) and Panton-Valentine leukocidin (PVL). Additionally, MRSA strain BM85 also possessed various antibiotic-resistant genes including tet38, tetK, blaZ, mecA, aph(3')-IIIa, aacA-aphD, and ermB which were located on mobile genetic elements MESPM1, Tn553-Tn4001 transposon, and a plasmid carrying the tetK gene, which was responsible for tetracycline resistance. The genotypic-resistant results were concordant with the phenotypic-resistant profile in which MRSA strain BM85 was resistant to penicillin, cefoxitin, gentamicin, kanamycin, tobramycin, erythromycin, and tetracycline. The sequencing data for the MRSA strain BM85 was deposited in GenBank, NCBI under accession number: BioProject PRJNA857185. In conclusion, the acquisition of the foreign genetic elements associated with antibiotic resistances through horizontal gene transfer mechanisms was the key driver of multidrug resistance in the multidrug-resistant MRSA strain BM85.
Long-COVID versus adverse event following COVID vaccination among students and staff of tertiary care teaching hospital
Authors: Javadekar Tanuja  B. , Barai Bhavin P. , Mistry Chirag B. , Sareen Ishaan , Vaishnav Riya 
Published: August 2023

Background: Long COVID is an important public health concern requiring proper defining, quantifying and describing following SARS-CoV infection with differentiation from adverse events due to COVID vaccination. So, this study was planned to analyze adverse effect of COVID19 vaccination or drug for COVID treatment versus consequences of COVID19 infection.
Methods: Self-reported data was collected through questionnaire-based survey by voluntary participation of healthcare staff. Percentage of participant developing various events was analyzed by enlisting sign, symptom, co-morbidity and medication history. Association between COVID-19 infection with number of doses of COVID-19 vaccine taken was analyzed by Chi Square Test with p value <0.05. Association between presence of specific sign, symptom after COVID infection or side effect after COVID vaccination was analyzed by Chi-Square Test with p value <0.05.
Results: Overall total 985 (59.58%) participants were analyzed and among them maximum number of participants (60.30%) reported as COVID-19 positive during the third wave with history of diagnosed COVID positive twice (57.87%). Participants with presence of co-morbidity were more likely to develop symptoms (p<0.001). On analysis, fever, body ache, headache, sore throat and fatigue were significantly more likely to develop after COVID infection as compared to after COVID vaccination (p<0.001).
Conclusions: This study by exploratory survey highlights heterogeneity of Long COVID sign or symptom that’s seen predominantly in person with co-morbidity and a few of them were mimicking adverse events after COVID vaccinations.
Formulation and evaluation of herbal hair serum-a review
Authors: R. Anusha , N. Akhila , J. Nikhitha , K. Harish , Shaikh Abdull Rajjak , Y. Sony , . Inamul 
Published: August 2023

In the mammalian system the hair follicle is known to the most significant organ that determine, appearance, gender distinction, provides intense temperature protection and plays a role in self-defence. The younger generations have begun to suffer extreme hair loss problem due to many reasons. The hair loss is not temporary in most cases. but it results in alopecia. Many people suffering from hair loss is in search of multiple treatments due to extreme anxiety and tension. To improve hair growth and to prevent hair loss, hair root activation is required. Citrus sinensis is used to antidandruff protection hair care. It’s had antibacterial and anti-inflammatory properties. Nigella sativa improves the shine, strength, volume, and texture of hair. Flax seed is full of fatty acids and antioxidants that tend to remove pollutants and dead cells from the scalp. Coconut oil may help to moisturise and seal hair. They can help to prevent dry, flaky scalp and dandruff. This review article focuses on the materials required for the formulation of hair serum and various evaluation tests to evaluate hair serum.
Brief remission of cardiac conduction defect under anaesthesia during trans-sphenoidal pituitary surgery
Authors: Kaur Kirandeep , Kaur Manpreet , Mahajan Shalvi 
Published: August 2023

Acromegaly can cause paroxysmal arrhythmia and bundle branch blocks, which may or may not be symptomatic. Physiological stress induced by anaesthesia can exacerbate cardiac problems; nevertheless, reversal of such problems can also occur despite being uncommonly reported. We describe temporary remission of left bundle branch block (LBBB) to normal sinus rhythm under general anaesthesia.
Social Presence, Negative Emotions, and Self-Protective Behavioral Intentions of Nonsmokers in Response to Secondhand Smoking in Virtual Reality: Quasi-Experimental Design
Authors: Liu Miao , Zhu Yicheng , Xu Zihan , Meng Sitong 
Published: August 2023

BackgroundThe application of virtual reality (VR) in health care has grown rapidly in China, where approximately half of the population is directly exposed to secondhand smoke (SHS). As VR headsets have become increasingly popular and short video platforms have incorporated 360° videos in China, new formats and opportunities for health campaigns about SHS have emerged.ObjectiveIn a simulated environment of exposure to SHS, this study aims to explore the emotional and behavioral responses to enhanced social presence brought about by VR in contrast to flat-screen videos. It also aims to examine whether and to what extent video modality (360° video vs flat-screen video) and contextual cues (high threat vs low threat) influence psychometric and intentional variables among viewers.MethodsA total of 245 undergraduate and graduate students who were nonsmokers and from a large university in China participated in this study between October 2020 and January 2021. This study created 4 different versions of a SHS experience in a café with a 2 (360° video on a head-mounted display vs flat-screen display) × 2 (high threat vs low threat) experimental design. It developed and tested a path model examining the effects of experience modality and threat levels on social presence, emotions (anger and disgust), and eventually behavioral intentions (staying away and asking for help).ResultsWe found that both video modality (P<.001) and threat level (P=.005) significantly influenced social presence, whereas the interaction of video modality and threat level did not have a statistically significant effect on social presence (P=.55). Negative emotions mediated the relationships between social presence and SHS-related self-protective behaviors. Specifically, anger positively predicted the intention to ask smokers to stop smoking through the waitress (P<.001). Disgust and fear both positively predicted the intention to stay away from the SHS environment (P<.001 for disgust; P=.002 for fear).ConclusionsThis study explored the potential mediating mechanisms that influence individuals’ responses to the risks of SHS in public areas. The results demonstrated that social presence and negative emotions are 2 important mediators that underlie the relationship between video modality and behavioral intention regarding SHS in a VR setting. These findings suggest that an immersive environment could be a better stimulator of anti-SHS emotions and behaviors than flat-screen videos.
Implementing Clinical Information Systems in Sub-Saharan Africa: Report and Lessons Learned From the MatLook Project in Cameroon
Authors: Bediang Georges 
Published: August 2023

Background
Yaoundé Central Hospital (YCH), located in the capital of Cameroon, is one of the leading referral hospitals in Cameroon. The hospital has several departments, including the Department of Gynecology-Obstetrics (hereinafter referred to as “the Maternity”). This clinical department has faced numerous problems with clinical information management, including the lack of high-quality and reliable clinical information, lack of access to this information, and poor use of this information.

Objective
We aim to improve the management of clinical information generated at the Maternity at YCH and to describe the challenges, success factors, and lessons learned during its implementation and use.

Methods
Based on an open-source hospital information system (HIS), this intervention implemented a clinical information system (CIS) at the Maternity at YCH and was carried out using the HERMES model—the first part aimed to cover outpatient consultations, billing, and cash management of the Maternity. Geneva University Hospitals supported this project, and several outcomes were measured at the end. The following outcomes were assessed: project management, technical and organizational aspects, leadership, change management, user training, and system use.

Implementation (Results)
The first part of the project was completed, and the CIS was deployed in the Maternity at YCH. The main technical activities were adapting the open-source HIS to manage outpatient consultations and develop integrated billing and cash management software. In addition to technical aspects, we implemented several other activities. They consisted of the implementation of appropriate project governance or management, improvement of the organizational processes at the Maternity, promotion of the local digital health leadership and performance of change management, and implementation of the training and support of users. Despite barriers encountered during the project, the 6-month evaluation showed that the CIS was effectively used during the first 6 months.

Conclusions
Implementation of the HIS or CIS is feasible in a resource-limited setting such as Cameroon. The CIS was implemented based on good practices at the Maternity at YCH. This project had successes but also many challenges. Beyond project management and technical and financial aspects, the other main problems of implementing health information systems or HISs in Africa lie in digital health leadership, governance, and change management. This digital health leadership, governance, and change management should prioritize data as a tool for improving productivity and managing health institutions, and promote a data culture among health professionals to support a change in mindset and the acquisition of information management skills. Moreover, in countries with a highly centralized political system like ours, a high-level strategic and political anchor for such projects is often necessary to guarantee their success.
The use of ondansetron in psychiatry: An educational article and expert opinion
Authors: Al-Mosawi Aamir Jalal 
Published: August 2023

Neuroleptics are anti-psychotics medications that are used in a variety of neuropsychiatric disorders including schizophrenia, anxiety, Tourette syndrome, autism, and mental retardation. The first and second generations of neuroleptics are dopamine 2 receptor blocker and the first generation agents are associated with significant risk of the occurrence of extra-pyramidal side effects in effective doses. Despite the emergence of several generations of neuroleptics, the disadvantages of the relatively high incidence of side effects and treatment resistance continued as challenging problems 1-6.
It has been suggested that these problems may be solved with use of adjunctive therapies that help in improving responsiveness and reduce the possibility of the occurrence of side effects. The aim of this paper is to provide a relevant educational overview of ondansetron research progress in the field of psychiatry.
Conclusion: The current expert opinion suggests that ondansetron has the potential to be the agent which can help in solving the problem associated with use of neuroleptics including the possibility of the occurrence of side effects and treatment resistance. There is preliminary evidence suggesting that ondansetron can be used as an adjunctive therapy in a variety of neuropsychiatric disorders including schizophrenia, Tourette syndrome, and obsessive-compulsive disorder.
Keywords: Ondansetron, neuropsychiatric disorders, expert opinion.