bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Unprecedented Crystalline La(II)-Chalcogenide LaMg6Ga6S16 with Multifunctional Properties
Authors: Yu Hongwei , Zhang Yujie , Chen Jiale , Wu Hongping , Hu Zhanggui , Wang Jiyang , Wu Yicheng 
Published: September 2023

Abstract
Divalent lanthanide inorganic compounds can exhibit unique electronic configurations and physicochemical proper-ties, yet their synthesis remains a great challenge because of the weak chemical stability. To the best of our knowledge, although several lanthanide monoxides epitaxial thin films have been reported, there is no chemically stable crystalline divalent lanthanide chalcogenide synthesized up to now. Herein, by using octahedra coupling tet-rahedra single/double chains to construct a novel octahedral crystal field, we synthesized the first stable crystalline La(II)-chalcogenide, LaMg6Ga6S16. The nature of the divalent La2+ cations can be identified by X-ray photoelectron spectroscopy, while the stability is confirmed by the in-situ variable-temperature powder X-ray diffraction and a series of solid-state reactions. Owing to the particular electronic characteristics of La2+(5d1), LaMg6Ga6S16 displays a broad-band green emission at 500 nm under the excitation of 360 nm. Clearly, this is the first time for La(II)-based com-pounds to exhibit luminescent properties.
Evaluation Of the effect of Modafinil in the improvement of the level of consciousness in patients with Covid-19 encephalopathy: a randomized controlled trial
Authors: Kiasari Fatemeh Talebi , Emamikhah Maziar , Lahiji Mohammad Niakan , Rohani Mohammad , Yazdi Narges , Naghshbandi Mobin , Ghafoury Roya , Movahedi Hamidreza , Amanollahi Alireza , Irandoost Pardis , Moghaddam Omid Moradi 
Published: September 2023

Abstract
Background
Covid-19 may cause encephalopathy leading to loss of consciousness. This study aimed to address this issue using modafinil.
Methods
This study was a double-blinded Randomized Clinical Trial conducted in The Rasoul Akram Hospital in Tehran, Iran. A total of 19 non-intubated Covid-related encephalopathy patients were divided into two treatment and placebo groups, receiving crushed Modafinil tablets and placebo starch powder, respectively. The drug was administered on a basis of a dose of 100 mg every two hours until reaching a peak dosage of 400 mg. In both groups, the level of consciousness was evaluated based on the Glasgow Consciousness Score (GCS) at 10, 8, 12, 14 and 16 hours on the day of medication administration. The trial registration number for this study is: IRCT20170903036041N3 which was registered on 23/5/2021. The obtained data were analyzed and compared between the two groups using SPSS version 26.
Results
The average age in the modafinil group and placebo group was 75.33 years and 70 years, respectively. There were no significant differences between the treatment and placebo groups in terms of chronic conditions, clinical symptoms, or laboratory data. GCS score was similar between the two groups (P-value = 0.699). GCS score was slightly higher in treatment group after four doses of Modafinil, which wasn’t meaningful (P-value = 0.581). GCS score after each round of drug administration wasn’t significantly different between treatment and placebo groups (P-value = 0.908).
Conclusion
Modafinil slightly improved the level of consciousness in patients with Covid-19 encephalopathy, which was not statistically significant compared to the control group.
The RNA binding protein IMP1/ZBP1 drives mRNA local translation in microglia and mediates polarized migration and phagocytosis in response to inflammation
Authors: Baleriola Jimena , Imaz-Iruretagoyena Josune , Blanco-Urrejola Maite , Cruz-Gambra Aida de la , Márquez Mar , Sierra Amanda 
Published: September 2023

Abstract
Polarized cells in the brain, such as neurons and glia, rely on the asymmetric distribution of their proteins compartmentalizing the function of dendrites, axons, glial projections and endfeet. Subcellular proteomes can be assembled either by the transport of proteins synthesized in the cell soma or by the delivery of mRNAs to target compartments where they are locally translated into protein. This latter mechanism is known as local protein synthesis or local translation, and it has been best studied in neurons. Increasing evidence suggest it is also required to maintain local protein homeostasis in glial cells, however, in microglia, local translation remains largely unexplored. Given the scant evidence, we aimed at exploring the existence of local translation in microglial peripheral processes (MPPs) and unravel its functional significance. We report that local translation indeed happens in MPPs and it is enhanced by triggering a microglial inflammatory response with bacterial lipopolysaccharides (LPS) suggesting a functional relevance of this molecular mechanism in response to inflammation. We found that Actb and Par3 mRNAs polarize to MMPs and are locally translated upon LPS exposure. Interestingly, downregulation of the Actb binding protein IMP1/ZBP1 impaired Actb mRNA polarization and its localized translation, leading to defects in filopodia distribution, lamellar directed migration and phagocytosis in microglia. Thus, our work contributes to recent findings that localized translation occurs in microglia and gives a mechanistic insight into the relevance of this molecular mechanism in fundamental microglial functions in response to LPS-induced inflammation.
Sub-Volt High-Speed Silicon MOSCAP Microring Modulator Driven by High Mobility Conductive Oxide
Authors: Wang Alan , Hsu Wei-Che , Nujhat Nabila , Kupp Benjamin , Conley John , Rong Haisheng , Kumar Ranjeet 
Published: September 2023

Abstract
Low driving voltage (Vpp), high-speed silicon microring modulator plays a critical role in energy-efficient optical interconnect and optical computing systems owing to its ultra-compact footprint and capability for on-chip wavelength-division multiplexing. However, existing silicon microring modulators usually require more than 2 V of Vpp, which is limited by the relatively weak plasma dispersion effect of silicon and the small capacitance density of the reversed PN-junction. Here we present a highly efficient metal-oxide semiconductor capacitor (MOSCAP) microring modulator through heterogeneous integration between silicon photonics and titanium-doped indium oxide, which is a high-mobility transparent conductive oxide (TCO) material with a strong plasma dispersion effect. The device is co-fabricated by Intel's photonics fab and TCO patterning processes at Oregon State University, which exhibits a high electro-optic modulation efficiency of 117 pm/V with a low Vπ•L of 0.12 V•cm, and consequently can be driven by an extremely low Vpp of 0.8 V. At a 11 GHz modulation bandwidth where the modulator is limited by the high parasitic capacitance, we obtained 25 Gb/s clear eye diagrams with energy efficiency of 53 fJ/bit and demonstrated 35 Gb/s open eyes with a higher driving voltage. Further optimization of the device is expected to increase the modulation bandwidth up to 52 GHz that can encode data at 100 Gb/s for next-generation, energy-efficient optical communication and computation with sub-volt driving voltage without using any high voltage swing amplifier.
Melanocortin 1 receptor (MC1R) expression as a marker of progression in melanoma
Authors: Su David , Djureinovic Dijana , Schoenfeld David , Marquez-Nostra Bernadette , Olino Kelly , Jilaveanu Lucia , Kluger Harriet 
Published: September 2023

Abstract

Melanocortin-1 receptor (MC1R) plays a critical role in human pigmentation and DNA repair mechanisms. MC1R-targeting agents are being investigated in clinical trials in melanoma patients, yet large studies investigating the rate and degree of MC1R expression in primary and metastatic human melanoma tissue are lacking. Using tissue microarrays containing three large cohorts of 225 cases of benign nevi, 189 with primary melanoma, and 271 with metastatic melanoma, we applied quantitative immunofluorescence and immunohistochemistry to comprehensively study MC1R protein expression. We show a stepwise elevation of MC1R expression in different stages of melanoma progression (nevi, primary, metastasis). Higher MC1R expression was seen in deeper (>1 mm) primary lesions, ulcerated lesions, and mucosal melanomas compared to cutaneous melanomas and was associated with shorter survival in primary and metastatic tumors. On multi-variable analysis, Breslow thickness, ulceration, male sex, and chronic sun exposure were independent predictors of worse overall survival in the primary melanoma cohort. In the metastatic melanoma cohort, MC1R expression and mucosal melanomas were independent predictors of inferior overall survival. Our data suggest that MC1R might be a valuable drug target in aggressive melanoma. Additional studies are warranted to determine its functional significance in melanoma progression and its utility as a predictive biomarker in patients receiving MC1R-directed therapies.
Heterogeneous effects on type 2 diabetes and cardiovascular outcomes of genetic variants and traits associated with fasting insulin.
Authors: Manning Alisa , Sevilla-González Magdalena , Smith Kirk , Wang Ningyuan , Jensen Aubrey , Litkowski Elizabeth , Kim Hyunkyung , DiCorpo Daniel , Westerman Kenneth , Cui Jinrui , Liu Ching-Ti , Yu Chenglong , McNeil John , Lacaze Paul , Chang Kyong-Mi , Tsao Phil , Phillips Lawrence , Goodarzi Mark , Sladek Rob , Rotter Jerome , Dupuis Josee , Florez Jose , Merino Jordi , Meigs James , Zhou Jin , Raghavan Sridharan , Udler Miriam 
Published: September 2023

Abstract
Hyperinsulinemia is a complex and heterogeneous phenotype that characterizes molecular alterations that precede the development of type 2 diabetes (T2D). It results from a complex combination of molecular processes, including insulin secretion and insulin sensitivity, that differ between individuals. To better understand the physiology of hyperinsulinemia and ultimately T2D, we implemented a genetic approach grouping fasting insulin (FI)-associated genetic variants based on their molecular and phenotypic similarities. We identified seven distinctive genetic clusters representing different physiologic mechanisms leading to rising FI levels, ranging from clusters of variants with effects on increased FI, but without increased risk of T2D (non-diabetogenic hyperinsulinemia), to clusters of variants that increase FI and T2D risk with demonstrated strong effects on body fat distribution, liver, lipid, and inflammatory processes (diabetogenic hyperinsulinemia). We generated cluster-specific polygenic scores in 1,104,258 individuals from five multi-ancestry cohorts to show that the clusters differed in associations with cardiometabolic traits. Among clusters characterized by non-diabetogenic hyperinsulinemia, there was both increased and decreased risk of coronary artery disease despite the non-increased risk of T2D. Similarly, the clusters characterized by diabetogenic hyperinsulinemia were associated with an increased risk of T2D, yet had differing risks of cardiovascular conditions, including coronary artery disease, myocardial infarction, and stroke. The strongest cluster-T2D associations were observed with the same direction of effect in non-Hispanic Black, Hispanic, non-Hispanic White, and non-Hispanic East Asian populations. These genetic clusters provide important insights into granular metabolic processes underlying the physiology of hyperinsulinemia, notably highlighting specific processes that decouple increasing FI levels from T2D and cardiovascular risk. Our findings suggest that increasing FI levels are not invariably associated with adverse cardiometabolic outcomes.
Influence of cutting intervals and intercropping patterns on yield and competition indices in a dual purpose wheat-canola intercropping system
Authors: Khil Aka , Arif Muhammad , Din Imadud , Gaafar Abdel-Rhman Z. , Hodhod Mohamed S. , Górnik Krzysztof , Mosa Walid F. A. , Khan Nazir Ahmad , Rasul Fahd , Khan Hamayoon , Sajid Muhammad 
Published: September 2023

Abstract
Background
The dual purpose intercropping system efficiently utilizes growth resources, ensuring the availability of fresh fodder for livestock and simultaneously stabilizing grain production. The purpose of this study was to assess how cutting intervals and intercropping pattern influence yield and competition indices of a dual-purpose wheat-canola intercropping system, in order to ensure the availability of both feed and food for livestock and humans. The experiment comprised of two factors: wheat-canola intercropping patterns (sole wheat, sole canola, 1:1, 2:2, 3:3, and 4:4 alternating rows of wheat-canola) and cut intervals [no-cut, cut at 60 and 75 days after sowing (DAS)].
Results
The results revealed that sole wheat and canola had higher fresh and dry fodder yields when cut at 75 DAS. In terms of grains spike− 1, biological yield, 1000-grains weight, and grain yield, the no-cut sole wheat and canola outperformed than intercropping. However, intercropping canola with wheat in a 2:2 row pattern resulted in a higher number of grains pod− 1 compared to sole canola. The competition indices of wheat-canola intercropping exhibited that wheat had the greatest advantage in the intercropping system across various parameters, including aggressivity, actual yield loss, competition ratio, area-time equivalent ratio, land utilization efficiency, intercropping advantage, monetary advantage index, relative crowding coefficient, land equivalent ratio and system productivity index. The wheat-canola intercropped in 1:1 alternative rows, cutting at 75 DAS and their interaction had the highest competition index values.
Conclusion
The present study concludes that intercropping wheat-canola in 1:1 alternative rows and cutting at 75 DAS will fulfil livestock feed requirements as well as provide grains for human consumption as food. Farmers should use a 1:1 alternative rows wheat-canola intercropping system and cut at 75 DAS to achieve long-term feed and food security.
Art Therapy Unmasked: Evaluating Emotional Shifts in Art Therapy Masks
Authors: Gonzalez Vicente Estrada , Meletaki Vasiliki , Walker Melissa , Sosa Janell Payano , Stamper Adrienne , Srikanch Rujirutana , King Juliet , Scott Kayleigh , Cardillo Eileen , Rhodes Sours , Christensen Alexander P. , Darda Kohinoor M. , Workman Clifford I. , Chatterjee Anjan 
Published: September 2023

Abstract
Among the disabling post-traumatic stress (PTS) symptoms are irritability, aggressive behavior, distressing memories and general impaired cognition and negative mood. Art therapy interventions, including mask-making, can potentially alleviate these symptoms. We tested the hypothesis that art conveys emotions and predicted that blinded viewers would be able to perceive changes in theoretically derived emotional profiles expressed in art made by military personnel with PTSS from the onset to the end of therapy. Five service members and veterans exhibiting PTSS were enrolled in an 8-session art therapy protocol, during which they artistically transformed papier-mâché masks at the beginning and end of the protocol. We found that blinded viewers without knowledge of the masks' creation stage (onset or end of therapy) read initial masks as conveying more negative emotions (e.g., angry, upset, and challenged) and later masks as conveying more positive emotions (calm and pleasure). Based on the assessments from the blinded evaluators, we infer the emotional transition experienced by the participants was expressed in the masks. In an exploratory arm of the study, we also found that viewers were better able to empathize with the negative emotions experienced by participants with PTSS when asked to explicitly take their perspective.
Development, characterization, and multiplex reaction of microsatellite loci in Lithraea molleoides (Anacardiaceae), a dominant tree from the mountains of Gran Chaco
Authors: Chiapero Ana Laura , Acosta María Cristina , Harvey Nick , Aguilar Ramiro , Ashworth Lorena 
Published: September 2023

Abstract

We develop and characterize 14 microsatellite primers in Lithraea molleoides, a dominant dioecious native tree to Gran Chaco mountains. Five of them were optimized for multiplex PCR and evaluated in natural populations of the species. In order to analyze the level of polymorphism, 63 individuals of L. molleoides were assessed from two localities of central Argentina. Two to six alleles per locus were found with an average effective number of 1.82 alleles. The mean expected heterozygosity in each studied locality was 0.405 and 0.436. In view of generating tools for the conservation of species in a context of ongoing habitat loss, this set of newly developed microsatellite markers will be fundamental for assessing the genetic diversity and differentiation, as well as gene flow patterns of L. molleoides populations throughout its distribution range.
The built environment, bus routes and bus ridership: multi-level analysis for the Buffalo area
Authors: Wang Chihuangji , Park Jiyoung 
Published: September 2023

Abstract

To prioritize public transit and make it more appealing, particularly in mid-sized cities on the rustbelt, it is essential to understand how the built environment affects transit ridership. Although many studies have looked at factors that influence ridership, there's still a need for a methodological design that considers both route and environment characteristics for bus ridership. This study examined daily ridership of 3,794 bus stops across 57 routes in Erie County, New York, and used random coefficients models to account for different levels of characteristics (bus-stop-level, route-level, and Transportation Analysis Zone (TAZ)-level). The study found that bus frequency was positively correlated with ridership, while total route stops had a negative effect. By controlling for the impact of bus routes, the study showed that the multi-level design using random coefficients models was more effective than traditional models in quantifying the impact of bus routes and TAZs. These findings provide local policy implications for route design, bus operation, and transit resource allocation, especially for mid-size cities that experienced urban sprawl.
Carbon Cycle in A Steelmaking Mill: Recycling of Kish Graphite and Its Subsequent Application for Steelmaking Carburant
Authors: Li Jihui , Xu Zeyang , Yang Ronghao , Ren Lingling , Ma Liqiang , Huang Gen , Zhang Shuang , Huang Zhenghong 
Published: September 2023

Abstract
The reclamation management of the solid waste produced by iron and steel enterprises is an urgent problem. The recycling and utilization of kish graphite associated with steel slag are of great significance to achieve a circular economy and environmental protection. This study explored a recycling process that combined gravity separation and flotation, and the feasibility of carburant preparation from kish graphite was determined. During the recycling process, the concentrate of a teeter bed separator went into a flotation tank, then the rougher flotation concentrate was re-ground four times and underwent cleaning flotation five times. The final concentrate held a yield of 20.28%, a grade of 94.85%, and a recovery rate of 95.32% and a kish-graphite-based carburant was prepared. The results indicated that recycling the kish graphite from steelmaking slag with a gravity-flotation process and using it as a carburant for steelmaking is a feasible route for its resource utilisation and an effective carbon emission reduction technology.
A facile method to determine the molar mass of soft nanoparticles
Authors: Thomas Schmidt , Moritz Becker , Frédéric Grabowski , Andreas Jupke , Andrij Pich , Dominik Wöll 
Published: September 2023

Abstract
The determination of the molar mass of soft nanoparticles is essential to estimate their (molar) concentration in dispersions. Methods to measure this quantity are, however, challenging. We describe a facile way to determine the molar mass of (soft) nanoparticles via counting their amount per volume using a widefield fluorescence microscope. As model system we applied it to microgels, but it is applicable to other types of stainable nanoparticles. The method does not require covalent labeling or modification of the nanoparticles. The dispersion is simply mixed with a Nile Red solution in a defined ratio and measured in an optical fluorescence microscope to which most researchers in the field have access.
Rapid Response Systems: Bibliometric and Visual Analysis
Authors: Long Jianying , Zhang Xiaoxiao , Zhong Mingming , Sun Shanshan , Ouyang Guoyuan , Wang Min , Zhang Zhigang 
Published: September 2023

Abstract
Background: Rapid response system (RRS) is a medical intervention system introduced to handle clinical deterioration and adverse events in hospitalized patients, which has significant implications for improving patient safety and outcomes. However, there is a lack of bibliometric studies on rapid response systems.
Objective: This study aimed to explore the status, hotspots, and emerging trends in medical rapid response systems.
Methods: We conducted a search on the Web of Science Core Collection (WOSCC) for studies on rapid response systems in healthcare institutions from 2003 to 2023. CiteSpace and VOSviewer were used to analyze countries, institutions, authors, journals, references, and keywords.
Results: The analysis included 3283 articles, showing a consistent increase in annual publications. The research covered various categories, including healthcare institutions, informatics, multidisciplinary knowledge, and clinical departments. The United States was the leading country in rapid response systems research, and universities were the primary research institutions. The most prolific author was Daryl Jones (56 publications), and the journal with the highest number of publications was RESUSCITATION (187 publications). The most co-cited and cited publications were authored by Singer M and Soar, Jasmeet, respectively. We concluded that current hot topics include "early warning scores", "medical emergency teams", "mortality", "intensive care" and "sepsis." Future research trends will focus on "sepsis and organ failure assessment," "artificial intelligence," and "accuracy."
Conclusion: Rapid response system is gradually attracting the attention of scholars. How to improve the effectiveness and efficiency of rapid response system implementation is a problem that needs to be studied and solved in the future.