bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visual Arts subject in high school education in Croatia in the context of educational changes and reforms from the mid-20th century to present-day / Likovna umjetnost u srednjoškolskom obrazovanju u Hrvatskoj od sredine 20. stoljeća do danas u kontekstu obrazovnih promjena i reformi
Authors: Nestić Jasmina 
Published: August 2023

The contents of art history in Croatian grammar schools had initially been included within the Drawing subject. From the mid-20th century, they were combined with the contents from history. From 1960, both Visual Arts and Music had been equal components within the Art course, but since 1994 it formally became a full independent subject in grammar schools. The last educational reform generated a new subject curriculum 2019 that completely reorganized the subject and brought it closer to contemporary educational principles. In vocational schools during the 1960s, however, a large number of teaching programs contained contents implemented from visual arts as a part of Croato-Serbian Language and Literature course together with the basics of aesthetic education. However, they were left out in the later programs from most schools during the 1990s, which happened again in the most recent educational documents that were issued in the last several years. The aim of this paper is to discuss the position and specific qualities of Visual Arts subject or topics from the field of visual arts (art history), as well as the changes this subject has underwent during various educational reforms, by means of analysing the teaching programs of grammar and vocational schools in Croatia from the mid-20th century to present-day.Key words: grammar school, teaching programs, art history, vocational schools --- Sadržaji iz povijesti umjetnosti u hrvatskim su gimnazijama prvotno bili predviđeni u sklopu predmeta Crtanje, a zatim su se sredinom 20. stoljeća našli u predmetnoj simbiozi sa sadržajima iz povijesti. Od 1960. Likovna umjetnost zajedno s Muzičkom umjetnosti ravnopravna je sastavnica predmeta Umjetnost, a od 1994. kao predmet u gimnazijama i formalno se posve osamostaljuje. Posljednja obrazovna reforma iznjedrila je novi predmetni kurikul 2019. kojim je predmet temeljito reorganiziran i približen suvremenim obrazovnim načelima. U pogledu strukovnih škola, tijekom sedmoga desetljeća 20. stoljeća izrazito veliki broj nastavnih programa imao je implementirane sadržaje iz likovne umjetnosti unutar predmeta Hrvatskosrpski jezik i književnost s osnovama estetskog obrazovanja, a koji su u kasnijim programima tijekom 1990-ih u većini škola posve izostavljeni, što se ponovilo i u najnovijim obrazovnim dokumentima nastalima u zadnjih nekoliko godina. Cilj je ovoga rada, kroz analizu nastavnih programa gimnazija i strukovnih škola u Hrvatskoj u periodu od sredine 20. stoljeća pa do danas, tematizirati položaj i specifičnosti predmeta Likovna umjetnost, odnosno sadržaja iz područja likovnih umjetnosti (povijesti umjetnosti) te promjene koje je predmet prošao tijekom raznih obrazovnih reformi.Ključne riječi: gimnazije; nastavni programi; povijest umjetnosti; strukovne škole
The Impact of Contemporary Art on the Creativity of Twelve-Year-Olds / Utjecaj suvremene umjetnosti na kreativnost dvanaestogodišnjaka
Authors: Kozjek Varl Katja , Herzog Jerneja 
Published: August 2023

This paper presents the outcomes of a study aimed at verifying the impact of contemporary fine arts on the creativity of twelve-year-old pupils. In the study, a proven creativity test was used, which was applied in the initial and final measurement of the quasi experiment on a sample of 75 twelve-year-olds (N = 75).The results indicate the positive effect of quality contemporary fine art practices on the development of artistic creativity in twelve-year-olds, specifically, in as many as five of the six factors of artistic creativity. This is why art education teachers should be made more aware of the positive effects of contemporary art on the practice of teaching arts.Key words: artistic creativity; contemporary art; creativity test; primary school. --- U ovom radu predstavljeni su ishodi istraživanja kojim se nastojalo potvrditi utjecaj suvremene likovne umjetnosti na kreativnost dvanaestogodišnjih učenika. U ovome je istraživanju korišten verificirani test kreativnosti u inicijalnom i završnom mjerenju kvazieksperimenta koji je proveden na uzorku od 75 dvanaestogodišnjaka.Rezultati pokazuju pozitivni učinak kvalitetnih praksi suvremene likovne umjetnosti na razvoj umjetničke kreativnosti posebno dvanaestogodišnjaka, u čak pet od šest čimbenika umjetničke kreativnosti. Zbog ove činjenice trebalo bi više razvijati svijest učitelja umjetnosti o pozitivnim učincima suvremene umjetnosti na praksu poučavanja umjetnosti.Ključne riječi: osnovna škola; suvremena umjetnost; test kreativnosti; umjetnička kreativnost.
Unified Mouse and Human Kidney Single-Cell Expression Atlas Reveal Commonalities and Differences in Disease States
Authors: Zhou Jianfu , Abedini Amin , Balzer Michael S. , Shrestha Rojesh , Dhillon Poonam , Liu Hongbo , Hu Hailong , Susztak Katalin 
Published: August 2023

Significance Statement
Mouse models have been widely used to understand kidney disease pathomechanisms and play an important role in drug discovery. However, these models have not been systematically analyzed and compared. The authors characterized 18 different mouse kidney disease models at both bulk and single-cell gene expression levels and compared single-cell gene expression data from diabetic kidney disease (DKD) mice and from patients with DKD. Although single cell–level gene expression changes were mostly model-specific, different disease models showed similar changes when compared at a pathway level. The authors also found that changes in fractions of cell types are major drivers of bulk gene expression differences. Although the authors found only a small overlap of single cell-level gene expression changes between the mouse DKD model and patients, they observed consistent pathway-level changes.

Background
Mouse models have been widely used to understand kidney disease pathomechanisms and play an important role in drug discovery. However, these models have not been systematically analyzed and compared.

Methods
We analyzed single-cell RNA sequencing data (36 samples) and bulk gene expression data (42 samples) from 18 commonly used mouse kidney disease models. We compared single-nucleus RNA sequencing data from a mouse diabetic kidney disease model with data from patients with diabetic kidney disease and healthy controls.

Results
We generated a uniformly processed mouse single-cell atlas containing information for nearly 300,000 cells, identifying all major kidney cell types and states. Our analysis revealed that changes in fractions of cell types are major drivers of differences in bulk gene expression. Although gene expression changes at the single-cell level were mostly model-specific, different disease models showed similar changes when compared at a pathway level. Tensor decomposition analysis highlighted the important changes in proximal tubule cells in disease states. Specifically, we identified important alterations in expression of metabolic and inflammation-associated pathways. The mouse diabetic kidney disease model and patients with diabetic kidney disease shared only a small number of conserved cell type–specific differentially expressed genes, but we observed pathway-level activation patterns conserved between mouse and human diabetic kidney disease samples.

Conclusions
This study provides a comprehensive mouse kidney single-cell atlas and defines gene expression commonalities and differences in disease states in mice. The results highlight the key role of cell heterogeneity in driving changes in bulk gene expression and the limited overlap of single-cell gene expression changes between animal models and patients, but they also reveal consistent pathway-level changes.
Bruno Winawer o tęsknocie. Analiza wybranych utworów
Authors: Warońska-Gęsiarz Joanna 
Published: August 2023

Autorka omawia funkcje tęsknoty i sposoby jej przedstawiania na przykładzie kilku wybranych utworów Brunona Winawera, twórcy debiutującego jeszcze w Młodej Polsce, któremu popularność i uznanie krytyki w dwudziestoleciu międzywojennym zapewniły przede wszystkim dramaty i felietony. Jako materiał analityczny wykorzystała teksty pochodzące z początkowej oraz końcowej fazy twórczości Winawera, sztuki: Niziny (1910), Księga Hioba (1921), Ryk byłego lwa (1936) i Żywy ładunek (1938), a także wiersz opublikowany na łamach „Chimery” (1907).
Analiza utworów Winawera pozwoliła autorce zdiagnozować tęsknotę jako konsekwencję odczucia braku albo doświadczenia straty, co wpłynęło na wyróżnienie spośród bohaterów ludzi tęskniących (tęskniących do czegoś; tęsknota pobudza ich do działania, które często ogranicza się niemal wyłącznie do realizacji nie zawsze jasno sprecyzowanego celu znajdującego się w bliżej nieokreślonej przyszłości) oraz ludzi tęsknych (doświadczonych stratą czegoś lub kogoś; biernych, zniechęconych, rozżalonych). Tęsknota postaci ujawnia się w ich słowach, zachowaniach oraz sposobie postrzegania świata, choć na siłę jej doświadczania wpływa również aktualne otoczenie i ukształtowanie świata przedstawionego. Autorka zastanawia się również nad tęsknotą ujawnianą w biografii Winawera.
Organic Contaminants are Degraded by Rhizospheric Microorganisms: A Review
Authors: Thakur Rajneesh 
Published: August 2023

Organic pollutants have grown to be a serious global problem because of their massive creation, widespread application, and eventual discharge. Due to biomagnification, accumulation, and their harmful acute and chronic impacts on all living things, these substances significantly increased the load on the ecosystem and its potential threats. Reducing the risk factors associated with organic contaminantsthrough rhizospheric microfilms is crucial. Rhizoremediation is phytoremediation that removes toxins from the soil using plant roots and the rhizospheric microorganisms living on them. Research has shown that one of the best techniques is bioremediation utilizing plants. Utilizing bacteria from plants offers a lot of potential for rhizoremediation. Dangerous environmental contaminants include toxic industry byproducts, polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), organochlorine insecticides, and polychlorinated biphenyls (PCBs). These substances are categorized as global concern chemicals due to their propensity to travel long distances, remain in the environment, and potential for bio-accumulation and bio-magnification through the food chain. Organic pollutants can be broken down from the soil by soil microflora, which can also promote plant development in stressful environments. Plant-microbe interaction is essential for removing contaminants from the soil. Cleaning up these and harmful pollutants is therefore essential together with microbes; phytoremediation is an economical way to remove the pollutants from the soil, air, and water that is also environmentally acceptable.
Assessing the efficacy of different formulations of organic granules immobilizing Azotobacter chroococcum and Bacillus subtilis on productivity and yield of wheat (Triticum aestivum L.) at different water regimes
Authors: Kumar Pawan , Singh Rana Pratap 
Published: August 2023

Microbial biofertilizers can be effective alternatives to fulfil plants' nutritional requirements as chemical fertilisers are considered unsustainable and a threat to environmental and health concerns. However, farmers hardly adopt these bioinoculants due to the uncertainty of their effectiveness in field conditions. In this study, we used porous dry organic materials obtained from biodegradable nontoxic agro-waste and process byproducts from agro-based industries which can act as a suitable carriers and protect the microbes during storage, marketing and field application. In this study, we created various formulations for Azotobacter chroococcum and Bacillus subtilis by combination presmud, cow dung manure as the organic matrix and jaggery, molasses, and serous gum as the binder and clay as the stabilizer. Azotobacter chroococcum and Bacillus subtilis increased straw and grain yield in wheat (Triticum aestivum L.) over the unimmobilized biofertilizers and other used matrixes and binders in irrigated as well as water stressed cropping conditions. The immobilized biofertilizers significantly increased soil fertility and nutrient availability compared to the unimmobilized PGPRs. The formulation IBF-VI showed a 35.9 and a 61.21% increase in grain and straw yields, respectively, over unimmobilized PGPRs. Interestingly, the biofertilizers immobilized in the organic matrix have supported similar grain and straw yield recorded for the synthetic chemical fertilizer’s urea and DAP. The performance of selected immobilized biofertilizers was further examined at various water regimes to measure their efficacy in wheat growing under water stress. The studies show that immobilizing microbial biofertilizers in sugar mill waste press mud and molasses for granule production improves the performance of the microbial biofertilizers. These compounds are abundant and inexpensive locally, and small-scale entrepreneurs can supply them on a small scale. The findings provide a new potential for producing and marketing customised effective microbial bio-fertiliser formulations in rural areas using small industrial setups.
Overcoming the Barriers to Diversity in Orthopaedic Surgery
Authors: Rama Essam , Ekhtiari Seper , Thevendran Gowreeson , Green Jennifer , Weber Kristy , Khanduja Vikas 
Published: August 2023

Background:
Diversity in orthopaedics continues to lag behind that in other surgical specialties. This pattern exists globally and is not unique to gender or race. This review offers a global perspective on overcoming the barriers to diversity in orthopaedics.

Methods:
A literature search of MEDLINE and Embase was conducted and a narrative review was undertaken. Publications that discussed any aspect of diversity or solutions to diversity within orthopaedics or academic orthopaedics were identified.

Results:
A total of 62 studies were included. Studies showed that diversity in orthopaedic training is limited by structural barriers such as long hours, requirements to relocate during training, training inflexibility, and a lack of exposure to orthopaedics. Implicit bias during the selection process for training, discrimination, and a lack of role models are additional barriers that are experienced by both minority and female surgeons. The global lack of diversity suggests that there are also inherent “cultural barriers” that are unique to orthopaedics; however, these barriers are not uniformly experienced. Perceptions of orthopaedics as promoting an unhealthy work-life balance and the existence of a “boys’ club” must be addressed. Strong, committed leaders can embed cultural norms, support trainees, and act as visible role models. Targeted efforts to increase diverse recruitment and to reduce bias in selection processes for medical school and specialty training will increase diversity in the “training pipeline.”

Conclusions:
Diversity in orthopaedics continues to lag behind that in other specialties. Increasing diversity is important for providing a more inclusive training environment, improving patient care, and reducing health disparities. Structural and cultural barriers need to be addressed to improve diversity in orthopaedics. Promoting a culture supportive of all surgeons is essential to reframing perceptions that may prevent individuals from even considering a career as an orthopaedic surgeon. Changing attitudes require focused efforts from committed leadership in a “top-down” approach that prioritizes diversity. The efforts from national bodies seeking to tackle the lack of diversity, as well as the establishment of organizations committed to diversity, such as the International Orthopaedic Diversity Alliance, provide reasons to be optimistic for the future.
Pengaruh Kualitas Produk, Harga dan Promosi Terhadap Keputusan Pembelian Mahasiswa Ponorogo di Marketplace Lazada
Authors: Intan Diah Eka Intan Pratiwi , Ely Ely Masykuroh 
Published: August 2023

The Lazada application is a Singapore private Marketplace application founded by Rocket Internet in 2011. Lazada is an online shopping center that offers various types of products. The decision to purchase has several considerations regarding product quality, price, place, and promotions offered. This purchase decision stage is an evaluation stage by consumers to buy the preferred product brand. This quantitative research aims to answer whether there is a positive influence between product quality, price, and promotion on purchasing decisions on the Lazada Marketplace. To test and analyze Product Quality, Price, and Promotion on consumer purchasing decisions on the Lazada Marketplace. The research method used is quantitative by collecting primary data through the survey method by distributing questionnaires to 100 Ponorogo students. The analytical method used is multiple linear regression. Hypothesis testing is done by statistical tests, namely the t-test (partial) and the F-test (simultaneous). The results of this study are based on the partial test (t-test) showing that the product quality variable has a positive effect on purchasing decisions. This can be seen from the t count of 2.250 with a sig value of 0.027. Based on the partial test (t-test) shows that the price variable has a positive effect on purchasing decisions on the Lazada Marketplace. This can be seen from the t count of 2.428 with a sig value of 0.017. Based on the partial test (t-test) shows that the promotion variable has a positive effect on purchasing decisions on the Lazada Marketplace. This can be seen from the t count of 3.198 with a sig value of 0.002. The F test results show that the variable product quality, price, and promotion positively and significantly influence purchasing decisions on the Lazada Marketplace. This can be seen from the acquisition of F count 37.264 with a sig value of 0.000.
Rapid Automatic Detection of Collapsed Buildings with LiDAR Data After an Earthquake
Authors: Canözü Ömer , Acar Hayrettin 
Published: August 2023

Abstract
Earthquakes are natural events that cannot be precisely determined in terms of their location and timing. In cases where measures are inadequate, there can be a significant loss of life and property damage. Minimizing the loss of life after an earthquake depends on identifying the collapsed structures and quickly delivering rescue teams. In this study, damaged and collapsed buildings were automatically detected using LiDAR point clouds produced after the earthquake and the cadastral map of the region. The algorithm developed in this study detected changes in the horizontal (X and Y) and vertical (H) directions in buildings. Damaged or collapsed buildings were automatically classified based on their 3D geometric changes. The developed approach achieved a 98% accuracy rate in detecting damaged and collapsed buildings after the earthquake. By processing the data obtained after the earthquake using the proposed approach, damaged and collapsed buildings can be identified in less than a day. This will speed up the planning and implementation of rescue and relief efforts. In addition, the importance of the proposed study is increased by the fact that it can prevent the loss of life caused by delayed interventions.
Cancers with kinase fusion exhibit fewer actionable alterations than those with kinase mutation and amplification
Authors: Suzuki Shinsuke , Akahane Toshiaki , Tanimoto Akihide , Higashi Michiyo , Kitazono Ikumi , Kirishima Mari , Nishigaki Masakazu , Ikeda Toshiro , Kanemitsu Shuichi , Nakazawa Junichi , Akahane Erina , Nishihara Hiroshi , Ishitsuka Kenji , Ueno Shin-ichi 
Published: August 2023

Abstract
Background
Kinase-related gene fusion and point mutations are important drivers, and optimized targeted therapy against these alterations is required. The effects of molecularly targeted therapeutics vary depending on the alteration, and such therapeutics have achieved their greatest success when used to treat chronic myelogenous leukemia with kinase fusion protein. In this study, we aimed to compare the numbers of actionable alterations in patients with kinase domain fusions, mutations, and amplifications.
Methods
To detect gene-fusion events, we analyzed 456 patients with 31 solid cancer types who visited our division between June 2020 and May 2023. We performed comprehensive genomic sequencing using FoundationOne® CDx (F1CDx) and FoundationOne® Liquid CDx (F1LCDx) to detect alterations involving multiple-fusion calling, and compared the number of actionable alterations in patients with kinase-domain fusions and mutations. The significance of these gene alterations was analyzed at a team conference.
Results
Among the 418 patients, we identified 44 with kinase-domain fusions, and F1CDx and F1LCDx detected 12 with kinase-domain fusions. We identified 78 patients with kinase-domain mutations and 33 with amplifications. The numbers of actionable alterations in patients with kinase-domain fusion, mutation, or amplification (median [IQR]) were 2 (0–3.5), 5 (4–7), and 5.5 (4.25–7.5), respectively. Patients with kinase fusion had significantly fewer actionable alterations than those with kinase-domain mutations and amplifications. However, those cancers with fusion involving tumor suppressors tended to have more passenger alterations (4 [2–9.75]; median [IQR]).
Conclusions
Cancers with kinase fusions tended to exhibit fewer actionable alterations than those with kinase mutations and amplifications. These findings indicate that kinase fusions are strong drivers of cancer development. In particular, kinase fusions in cancer are considered ideal targets for molecular therapeutics.
Anal Localization of Tuberculosis, a Rare Extra-Pulmonary Form: A Case Report
Authors: Bahrou Najib , messaoudi Imane El , Maazouz Amine , Laraqui Hicham , Tajedine Mohammed Tariq 
Published: August 2023

Abstract

Gastrointestinal localizations of tuberculosis account for approximately 1% of cases of extra-pulmonary tuberculosis, and anoperineal localizations are sporadically reported in the literature. In this article, we present a case of tuberculosis anal fistula that showed favorable evolution with medico-surgical treatment. We also discuss the diagnostic modalities and management approaches for this pathology.