bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymptomatic people with well-controlled HIV do not have abnormal left ventricular global longitudinal strain
Authors: Hoy Jennifer F. , Lee Sue J. , Trevillyan Janine M. , Dewar Elizabeth M. , Roney Janine , Dart Anthony , Yang Yan 
Published: July 2023

BackgroundPrevious studies have reported impairment in systolic and diastolic function in people with HIV (PWHIV). Our aim was to determine if echocardiographically measured left ventricular (LV) global longitudinal strain (GLS) is abnormal in asymptomatic PWHIV.MethodsA cross-sectional study of PWHIV (n = 98, 89% male, median age 53 years) and HIV-negative people (n = 50, median age 53 years) without known cardiovascular disease were recruited from a single centre. All participants completed a health/lifestyle questionnaire, provided a fasting blood sample, and underwent a comprehensive echocardiogram for assessment of diastolic and systolic LV function, including measurement of GLS.ResultsAll PWHIV were receiving antiretroviral therapy (ART) for a median of 12 years (IQR: 6.9, 22.4), the majority with good virological control (87% suppressed) and without immunological compromise (median CD4 598 cells/µl, IQR: 388, 841). Compared with controls of similar age and gender, there was no difference in GLS [mean GLS −20.3% (SD 2.5%) vs. −21.0% (SD 2.5%), p = 0.14] or left ventricular ejection fractions [65.3% (SD 6.3) vs. 64.8% (SD 4.8), p = 0.62]. Following adjustment for covariates (gender, heart rate, systolic and diastolic blood pressure, and fasting glucose), the difference in GLS remained non-significant. There were no differences in LV diastolic function between the groups. Exposure to at least one mitochondrially toxic ART drug (didanosine, stavudine, zidovudine, or zalcitabine) was not associated with impairment of LV systolic function.ConclusionNo clinically significant impairment of myocardial systolic function, as measured by LV GLS, was detected in this predominantly Caucasian male population of PWHIV on long-term ART, with no history of cardiovascular disease.
Alterations of natural killer cells activatory molecules phenotype and function in mothers of ASD children: a pilot study
Authors: Saresella Marina , Marventano Ivana , Piancone Federica , Bolognesi Elisabetta , Hernis Ambra , Zanzottera Milena , La Rosa Francesca , Agliardi Cristina , Giraldo Stefano , Chiappedi Matteo , Guerini Franca Rosa , Clerici Mario 
Published: July 2023

IntroductionAutism spectrum disorder (ASD) is accompanied by complex immune alterations and inflammation, and the possible role played by Natural Killer (NK) in such alterations is only barely understood.MethodsTo address this question we analysed activating and inhibitory NK receptors, as well as NK cells phenotype and function in a group of mothers of children who developed ASD (ASD-MO; N=24) comparing results to those obtained in mothers of healthy children who did not develop (HC-MO; N=25).ResultsResults showed that in ASD-MO compared to HC-MO: 1) NK cells expressing the inhibitory receptor ILT2 are significantly decreased; 2) the activating HLA-G14bp+ polymorphism is more frequently observed and is correlated with the decrease of ILT2-expressing cells; 3) the CD56bright and CD56dim NK subsets are increased; 4) IFNγ and TNF production is reduced; and 5) perforin- and granzymes-releasing NK cells are increased even in unstimulated conditions and could not be upregulated by mitogenic stimulation.DiscussionResults herein reinforce the hypothesis that ASD relatives present traits similar to, but not as severe as the defining features of ASD (Autism endophenotype) and identify a role for NK cells impairment in generating the inflammatory milieu that is observed in ASD.
New Species of Didymellaceae within Aquatic Plants from Southwestern China
Authors: Chen Tong , Wang Siyuan , Jiang Xinwei , Huang Ying , Mo Minghe , Yu Zefen 
Published: July 2023

Members of Didymellaceae have a wide geographical distribution throughout different ecosystems, and most species are associated with fruit, leaf, stem and root diseases of land plants. However, species that occur in aquatic plants are not clearly known. During a survey of the diversity of endophytes in aquatic plants in Yunnan, Sichuan, and Guizhou provinces, we obtained 51 isolates belonging to Didymellaceae based on internal transcribed spacer region (ITS) sequences. Further, the phylogenetic positions of these isolates were determined by combined sequences composed of ITS, partial large subunit nrRNA gene (28S nrDNA; LSU), RNA polymerase II second largest subunit (rpb2) and partial beta-tubulin gene (tub2). Combining morphological characteristics and multi-locus phylogenetic analyses, two new varieties belong to Boeremia and 12 new species distributed into seven genera were recognized from 51 isolates, i.e., Cumuliphoma, Didymella, Dimorphoma, Ectophoma, Leptosphaerulina, Remotididymella, and Stagonosporopsis. Among these species, only one species of Stagonosporopsis and two species of Leptosphaerulina show teleomorphic stages on OA, but have no anamorphic state. Each new species is described in detail, and the differences between new species and their phylogenetically related species are discussed here. The high frequency of new species indicates that aquatic plants may be a special ecological niche which highly promotes species differentiation. At the same time, the frequent occurrence of new species may indicate the need for extensive investigation of fungal resources in those aquatic environments where fungal diversity may be underestimated.
Coconut (Cocos nucifera L.) inflorescence sap-derived sugar restores the glucose and lipid homeostasis in streptozotocin-induced diabetic Wistar rat model
Authors: S. Shetty Shilpa , S. V. Ramesh , M. Arivalagan , P. G. Roopashree , M. R. Manikantan , K. B. Hebbar , Kumari Suchetha 
Published: July 2023

Introduction and Aim: Coconut palm sugar (CPS) is a functional food comprising unique phytonutrients such as polyphenolics, minerals, inulin, etc., and has a low glycemic index (GI). Based on its distinctive biochemical composition, it was hypothesized that CPS would provide a glucose homeostatic effect. We investigated the effects of CPS oral administration in Wistar rats with streptozotocin-induced diabetes.

Materials and Methods: Diabetic Wistar rats were administered with different doses of CPS (200,400 and 800 mg/Kg body weight) and standard gliclazide (5 mg/Kg b.w.) for 28 days. Biochemical estimations for fasting blood glucose, lipid profile and antioxidant status were performed.

Results: Treatment with CPS significantly (P 0.001) decreased the plasma glucose levels at 120 min after glucose load. Serum blood glucose, hepatic enzymes (alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (AP)), total cholesterol (TC), total triglycerides (TG), and low-density lipoprotein (LDL) levels were also decreased. However, levels of total serum protein and high-density lipoprotein (HDL) increased in a significant manner. Pancreatic enzymatic antioxidant levels were restored, and lipid peroxidation was decreased by CPS.

Conclusion: CPS showed quite a few health benefits in diabetic rats by bringing back the glucose and lipid homeostasis to normal and yielded favorable outcomes in case of oxidative stress.
TO THE ISSUE OF MATERIAL CONDITIONS OF THE TRANSPORT EXPEDITION CONTRACT
Authors: Гимадрисламова О.Р. , Ахтямова Е.В. 
Published: July 2023

В статье исследована проблема определения существенных условий договора транспортного экспедирования в связи с тем, что Закон РФ «О транспортно-экспедиторской деятельности» перечисляет только структурные элементы этого договора. Определена классификация условий договора транспортного экспедирования, исследована целесообразность такой классификации.
The article investigated the problem of determining the essential conditions of the transport forwarding contract due to the fact that the Law of the Russian Federation "On Forwarding Activities" lists only the structural elements of this contract. The classification of the terms of the transport forwarding contract was determined, the feasibility of such a classification was investigated.
Network meta-analysis of multiple doses of vonoprazan for the treatment of erosive esophagitis
Authors: He Jie , Gao Yuanyuan , Bai Ge , Wang Jie , Sun Yongshun 
Published: July 2023

Aim:
20 mg of vonoprazan (VPZ20) is recommended in most countries to treat erosive esophagitis (EE). Whether other doses of vonoprazan, such as 5 mg (VPZ5), 10 mg (VPZ10), 20 mg (VPZ20), and 40 mg (VPZ40) are more effective is unknown.
Materials & methods:
Three databases were electronically searched to identify studies published before November 2021. Network meta-analysis was performed using STATA 14.0.
Results:
VPZ20 and VPZ40 were comparable to PPI, VPZ5 and VPZ10 in 4- and 8-week healing rates, and this was also detected in patients with refractory EE. All regimens resulted in similar treatment-emergent adverse events (TEAEs). However, VPZ40 ranked first for healing rate and TEAEs; however, VPZ20 ranked worst for TEAEs.
Conclusion:
Different doses of VPZ are comparable in efficacy and safety, but VPZ40 may be best in both effectiveness and safety.
Pengaruh Bauran Promosi Terhadap Citra Sekolah Pada Grage Kids Playschool Cirebon
Authors: Aldiella Utami Talahatu  
Published: July 2023

This study aims to analyze the effect of the promotion mix on the school image of Grage Kids Playschool Cirebon. The method used in this research is descriptive method. The techniques used are interviews, questionnaires, observations, documentation. The sample of this study was determined as many as 30 students or all students from Grage Kids Playschool Cirebon with the reason because the population is below 100 according to Sugiyono's opinion (2014: 116) that is if it is less than 100, then the sample is taken from the whole so called research population. This research uses data analysis methods in the form of validity test, reliability test, normality test, coefficient of determination, simple linear regression analysis test. Based on the calculation of SPSS v20.0 for windows, the results show that the Promotion Mix (X) significantly influences the School Image (Y), where the Promotion Mix of the School Image at 6,538> 2.048 table then H0 is rejected and H1 is accepted. Based on the SPSS v20.0 test results for windows shows that if the value of the Promotional Mix increases by one unit, the value of the School Image will increase by 0.405 at a constant of 46.037. That the Promotional Mix has a significant effect on the school image of Grage Kids Playschool Cirebon. This is known in the analysis of the coefficient of determination which shows that the Promotion Mix significantly influences the School Image of 60.40% and the remaining 39.60% is influenced by other variables.
ABSTRAK
Penelitian ini bertujuan untuk menganalisis pengaruh bauran promosi terhadap citra sekolah pada Grage Kids Playschool Cirebon. Metode yang digunakan dalam penelitian ini adalah metode deskriptif. Teknik yang digunakan adalah wawancara, kuisioner, observasi, dokumentasi. Sampel penelitian ini ditentukan sebanyak 30 siswa dan siswi atau seluruh siswa dan siswi dari Grage Kids Playschool Cirebon dengan alasan karena populasinya dibawah 100 sesuai dengan pendapat Sugiyono (2014:116) yaitu apabila kurang dari 100, maka sampel diambil dari keseluruhan yang ada sehingga disebut penelitian populasi. Penelitian ini menggunakan metode analisis data yang berupa uji validitas, uji reliabilitas, uji normalitas, koefisien determinasi, uji analisis regresi linier sederhana. Berdasarkan perhitungan SPSS v20.0 for windows menunjukan hasil bahwa Bauran Promosi (X) berpengaruh secara signifikan terhadap Citra Sekolah (Y), dimana antara Bauran Promosi terhadap Citra Sekolah thiutng 6,538 > ttabel 2,048 maka H0 ditolak dan H1 diterima. Berdasarkan hasil pengujian SPSS v20.0 for windows menunjukan jika nilai Bauran Promosi meningkat satu kali satuan, maka nilai Citra Sekolah akan meningkat sebesar 0,405 pada konstan 46,037. Bahwa Bauran Promosi berpengaruh signifikan terhadap Citra Sekolah pada Grage Kids Playschool Cirebon. Hal ini diketahui dalam analisis koefisien determinasi yang menunjukan bahwa Bauran Promosi berpengaruh signifikan terhadap Citra Sekolah sebesar 60,40% dan sisanya 39,60% dipengaruhi oleh variabel lain.
The Impact of Insurance Restrictions in Newly Diagnosed Individuals With Multiple Sclerosis
Authors: Mizell Ryan 
Published: July 2023

ABSTRACT

BACKGROUND:
The medical system in the United States has been riddled with insurance restrictions used by insurance companies to limit health care costs. The effects of insurance restrictions on patients receiving disease-modifying therapies for multiple sclerosis (MS) have not been specifically studied.

METHODS:
A retrospective cross-sectional study of 52 individuals recently diagnosed with MS at a tertiary neurology clinic was conducted to measure the association between prior authorization (PA) duration and other variables of interest. The Cox proportional hazards model was used to determine likelihood of approval. Further analysis included multivariable logistic regression to assess the influence of variables of interest on the initial decision from the insurance company and the effect of the PA on disease activity.

RESULTS:
Of 52 PAs, 50% were initially denied. An initial denial decreased the likelihood of approval by 98% (HR, 0.02; 95% CI, &lt;0.01-0.09; P &lt; .001). The odds of denial for oral medications (odds ratio [OR], 4.91; 95% CI, 1.33-21.52; P = .02) and infusions (OR, 8.35; 95% CI, 1.10-88.77; P = .05) were significantly higher than for injections. Medicaid had higher odds of denial compared with commercial insurance (OR, 4.51; 95% CI, 1.13-22.01; P = .04). An initial denial by insurance significantly increased the likelihood of disease activity (OR, 6.18; 95% CI, 1.33-44.86; P = .03).

CONCLUSIONS:
Insurance restrictions delay necessary treatments, increase the likelihood of disease activity, and rarely change the approved disease-modifying therapy. Reducing PAs may lead to improved outcomes for patients with MS.
Light‐Based 3D Printing of Complex‐Shaped Photonic Colloidal Glasses
Authors: Llorens Jorge Sanchez , Barbera Lorenzo , Demirörs Ahmet F. , Studart Andre R. 
Published: July 2023

AbstractColloidal glasses display angle‐independent structural color that is tunable by the size and local arrangement of sub‐micrometer particles. While films, droplets, and microcapsules with isotropic structural color have been demonstrated, the shaping of colloidal glasses in three dimensions remains an open manufacturing challenge. Here, a light‐based printing platform for the shaping of colloidal glasses into 3D objects featuring complex geometries and vivid structural color after thermal treatment is reported. Rheology, photopolymerization, and calcination experiments are performed to design the photoreactive resins leading to printable colloidal glasses. With the help of microscopy, scattering, and optical characterization, it is shown that the photonic properties of the printed objects reflect the locally ordered microstructure of the glass. The capability of the platform in creating 3D objects with isotropic structural color is illustrated by printing lattices and miniaturized sculpture replicas with unique shapes and multimaterial designs.
A Spidroin‐Inspired Hierarchical‐Structure Binder Achieves Highly Integrated Silicon‐Based Electrodes
Authors: Mu Pengzhou , Zhang Shu , Zhang Huanrui , Li Jiedong , Liu Zhi , Dong Shanmu , Cui Guanglei 
Published: July 2023

AbstractAs a promising component for next‐generation high‐energy lithium‐ion batteries, silicon‐based electrodes have attracted increasing attention by virtue of their ultrahigh theoretical specific capacities. Nevertheless, fast capacity fading posed by tremendous silicon‐based electrode volume changes during cycling remains a huge challenge before large‐scale applications. In this work, an aqueous–oil binary solution based blend (AOB) binder characterized by a spidroin‐like hierarchical structure for tolerating the huge volume changes of silicon‐based electrodes is developed. In the AOB binder, the polymer, containing hydrophobic tetrazole groups, denoted as PPB, and the water‐soluble amorphous poly(acrylic acid), mimick the β‐sheet and α‐helix structure of spidroin, respectively. Benefitting from such biomimetic design, the AOB binder enables both high tensile strength and elasticity, and strong electrode adhesion, therefore apparently stabilizing the silicon‐based electrode structure and rendering prolonged electrode cycle life. Such a strategy endows 3.3 Ah soft package cells assembled with Si/C composite anode and NCM811 cathode with a discharge specific capacity of 2.92 Ah after 700 cycles. This work marks a milestone in developing state‐of‐the‐art silicon‐based electrodes toward high‐energy‐density lithium‐battery applications.
Pyridine‐Regulated Lamellar Nickel‐Based Metal–Organic Framework (Ni‐MOF) for Nonenzymatic Electrochemical Glucose Sensor
Authors: Zhang Qian , Li Panpan , Wu Jun , Peng Yi , Pang Huan 
Published: July 2023

Abstract2D metal–organic frameworks (MOFs) are considered as promising electrochemical sensing materials and have attracted a lot of attention in recent years. Compared with bulk MOFs, the construction of 2D MOFs can increase the exposure of active sites by obtaining a larger surface area ratio. Herein, a facile one‐pot hydrothermal synthesis of pyridine‐regulated lamellar Ni‐MOFs with ultrathin and well‐defined 2D morphology is described. Compared with the bulk structure, the 2D lamellar Ni‐MOF has higher surface area and active site density, showing better electrochemical glucose sensing performance. The 2D lamellar Ni‐MOF exhibits a fast amperometric response of less than 3 s and a high sensitivity of 907.54 µA mm−1 cm−2 toward glucose with a wide linear range of 0.5–2665.5 µm. Furthermore, the 2D lamellar Ni‐MOF also possesses excellent stability and reproducibility, and can be used to detect glucose with high accuracy and reliability in different environments.
The sequential approach in eating disorders: A scoping systematic review
Authors: Tomba Elena , Tecuta Lucia 
Published: July 2023

AbstractObjectiveThe sequential model has been defined as an intensive, two‐stage approach that comprises administering two types of treatment consecutively to improve treatment outcomes in cases of non‐optimal or absence of treatment response. A psychiatric population that would potentially benefit from the application of the sequential model is the eating disorders (EDs) population. The current scoping review aimed to explore the emerging literature on the application of sequential treatments in EDs.MethodUsing PRISMA and Population intervention comparison outcomes study guidelines, Pubmed and PsycINFO were systematically searched for studies which applied temporally sequential treatments in patients diagnosed with EDs from inception to April 2022 using a combination of keywords. Studies utilising combined or integrated approaches were excluded.ResultsA total of 12 studies were selected and reviewed. Studies included Bulimia Nervosa, Binge Eating Disorder (BED), or mixed ED samples with a majority of female patients. No studies on AN samples were identified. The majority of studies contained a Cognitive‐Behavioural Therapy module of treatment, were conducted on BED patients, were in outpatient settings, and included a group format in one or more treatment conditions. Studies varied in number of comparison groups and study design. Secondary and sequentially applied treatment modules were consistent with treatment recommendations of clinical guidelines.ConclusionsThe available data on sequential treatments in EDs is scarce and exhibits methodological limitations that should be addressed in future studies. Definition of sequential treatments in EDs should be further developed to guide robust clinical research and improve empirical support of sequential treatment for complex ED cases and for non‐optimal ED treatment response.
Novel technologies for improving quality of tofu products and their packaging: A critical overview
Authors: Du Jie , Zhang Min , Qiu Liqing , Mujumdar Arun S. , Ma Yamei 
Published: July 2023

AbstractThere are many kinds of tofu products, and they are mainly found in Asia. This paper mainly summarizes and classifies the tofu products of different countries through the analysis of the characteristics of different products and the differences between them. The storage conditions for most bean products are typically harsh, resulting in the shelf life of some fresh beans limited to 3–5 days. The new packaging technology avoids the shortcomings of traditional packaging, which makes it more effective to store. In this paper, biodegradable packaging materials, nanomaterials, active packaging, and intelligent packaging were reviewed. The significance of this review is to introduce various types of tofu products to gain a more comprehensive understanding of their advantages and disadvantages and to apply different packaging techniques to improve the preservation environment of tofu products. The purpose is to find suitable packaging technology, materials, and development route of tofu products.
Educating professional counselors about the social determinants of mental health
Authors: Sheperis Carl J. , Cuff Patricia , Sheperis Donna 
Published: July 2023

AbstractThe social determinants of health (access to quality health care; economic stability; high‐impact educational opportunities; community safety and support; and connected social networks) play a central role in individual health and wellness. These determinants and others also impact individual mental health and wellness. A shift is required in the preparation of counselors toward training students and current practitioners to assess, diagnose, and treat mental health issues through a social determinants’ lens. While the Council for the Accreditation of Counseling and Related Educational Programs and counseling ethics require that counseling training focus on diversity, equity, inclusion, and belonging, there is no mention of the social determinants in any guidelines. We present a rationale for including the social determinants as a core component of counselor preparation and provide examples to facilitate the incorporation of the social determinants into counselor education curriculum and continuing education efforts.
Facile one‐pot synthesis of PEG‐derived carbon dots with enhanced luminescence via L‐cysteine‐assisted S,N‐doping
Authors: De Juan‐Corpuz Lyn Marie , Corpuz Ryan D. 
Published: July 2023

AbstractCarbon nanodots (C‐dots) are promising photoluminescent nanomaterials for biomedical applications. Among them, PEG‐derived C‐dots demonstrate exceptional photoluminescence and passivation properties, making them particularly attractive for use in the biomedical field. In this article, we present the synthesis of photoluminescent S,N‐doped PEG‐derived carbon dots that are stable at ambient temperature and can be produced using an easy hydrothermal technique. To synthesize the carbon dots, the non‐hazardous polymer polyethylene glycol (PEG) was used as the sole precursor rather than any other potentially hazardous compounds. The absence of L‐cysteine in the reaction mixture resulted in carbon dots with no significant absorbance in the visible region but exhibited photoluminescence properties with a maximum excitation and emission at 343 and 452 nm, respectively. However, the addition of L‐cysteine resulted in a visible absorbance and a red shift in both the maximum excitation and emission, at around 435 and 503 nm, respectively. The Fourier transform infrared spectroscopy (FTIR) analysis provided evidence for the presence of ‐SH, ‐SO2, ‐NH2, and CON‐H bond stretching after the addition of L‐cysteine, suggesting possible S,N‐doping of the carbon dots, which likely caused the observed changes in photoluminescence properties. These findings contribute to the understanding of S,N‐doping in carbon dots and highlight their potential applications in optoelectronics, sensing, and biomedical imaging.