bluuebunny/crossref_metadata_2025_split huggingface dataset:
New approach of stereotactic aspiration combine with neuroendoscopy and decompressive craniectomy for spontaneous supratentorial intracerebral hemorrhage with tentorial herniation
Authors: Cai Qiang , Li Zhiyang , Wang Wenju , Lei Pan , Song Ping , Zhou Long , Cheng Li , Gao Lun , Wei Hangyu , Hua Qiuwei , Chen Qianxue , Xiao Xiaohua , caiqiang Bangqing 
Published: April 2023

Abstract
Objective
To introduce a new “three-in-one technique” surgical approach of "stereotactic aspiration + neuroendoscopy + decompressive craniectomy” for spontaneous supratentorial intracerebral hemorrhage (SSICH) with tentorial herniation patients and to explore its preliminary application.
Methods
On our previous “two-in-one technique” operation, we further combined decompressive craniectomy to form a special surgical approach for SSICH with tentorial herniation patients. The operation included three steps: 1. Burr hole and aspirate partially clot to rapidly decrease intracranial pressure (ICP); 2. Remove the residual hematoma and stop the bleeding under neuroendoscope; 3. Decompressive craniectomy for further complete decompression. Clinical data of 17 patients with SSICH and cerebral hernia who underwent this approach in our department from January 2019 to February 2022 were collected, and time to access hematoma, hematoma evacuate rate and the outcome were analyzed.
Results
All procedures were successfully completed and the average access time to hematoma was 4.8 minutes in “three-in-one technique” group, which was much less than in craniotomy group (36.3 minutes) and neuroendoscopy group (9.9 minutes). Among the 17 patients, 3 died, 7 give up, 5 improved and 2 clinical cured. The poor prognosis (Death + Give up ) was 58.8% which was much better than traditional craniotomy group in previously published studies.
Conclusions
This “three-in-one technique” surgical approach combines the advantages of rapid decompression by stereotactic aspiration, full decompression and minimizing iatrogenic brain injury by neuroendoscope, complete decompression by decompressive craniectomy, which is a beneficial attempt for SSICH with tentorial herniation patients.
N1-Methylnicotinamide: The Mysterious Anti-aging Actor in Renal Transplantation
Authors: Nejabati Hamid Reza , Roshangar Leila 
Published: April 2023

Abstract:
The fast global aging of people worldwide is a crucial demographic trend. According to evidence,
Americans aged 65 and above will compose 21.6% of the population by 2040. During the aging process, the
kidney undergoes gradual functional decrease, which turned out to be a forthcoming problem in clinical practice.
Age-related decrease in renal function, evaluated by total glomerular filtration rate (GFR), which has been
shown to drop by approximately 5-10% per decade after the age of 35. The sustaining extended period renal
homeostasis is the main purpose of any therapeutic options intended for delaying or even reversing the aging
kidney. The renal transplant has been regarded as the common alternative for kidney replacement therapy for
elderly patients with end-stage renal disease (ESRD). In the last few years, considerable progress has been
made to find novel therapeutic options for alleviating renal aging, in particular, calorie restriction and pharmacologic
therapy. Nicotinamide N-methyltransferase is an enzyme responsible for generating N1-Methylnicotinamide
(MNAM), notorious for its anti-diabetic, anti-thrombotic, and anti-inflammatory activity. MNAM is
one of the important factors regarded as in vivo probes for evaluating the activity of some renal drug transporters.
Furthermore, it has been shown to have therapeutic potential in the pathogenesis of proximal tubular
cell damage and tubulointerstitial fibrosis. In this article, in addition to addressing the role of MNAM in renal
function, we also explained its anti-aging effects. We conducted an in-depth investigation of the urinary excretion
of MNAM and its metabolites, especially N1-methyl-2-pyridone-5- carboxamide (2py) in RTR. The excretion
of MNAM and its metabolite, 2py, was inversely correlated with the risk of all-cause mortality in renal
transplant recipients (RTR), independent of possible confounders. Therefore, we have shown that the reason for
the lower mortality rate in RTR who had higher urinary excretion of MNAM and 2py may be related to the anti-
aging effects of MNAM through transiently generating low levels of reactive oxygen species, stress resistance
and the activation of antioxidant defense pathways.
Countermeasures for Maintaining Cardiovascular Health in Space Missions
Authors: Kumar Akash , Pramanik Jhilam , Panchal Lakshay , Prajapati Bhupendra 
Published: April 2023

Abstract:During space exploration, the human body is subjected to altered atmospheric environments and gravity, exposure to radiation, sleep disturbance, and mental pressures; all these factors are responsible for cardiovascular diseases. Under microgravity, the physiological changes related to cardiovascular diseases are the cephalic fluid shift, dramatic reduction in central venous pressure, changes in blood rheology and endothelial function, cerebrovascular abnormalities, headaches, optic disc edema, intracranial hypertension, congestion of the jugular vein, facial swelling, and loss of taste. Generally, five countermeasures are used to maintain cardiovascular health (during and after space missions), including shielding, nutritional, medicinal, exercise, and artificial gravity. This article concludes with how to reduce space missions' impact on cardiovascular health with the help of various countermeasures.
Alpha-amylase Inhibitory Activity of Extracts from Algerian Calamintha
nepeta (L.)
Authors: Benabed Khadidja Houda , Boussoussa Hadjer , Khacheba Ihcen , bekhaoua Abir , Douadji Fatima Zohra , Daïdi Sabrina , Djaâfour Souad , Yousfi Mohamed 
Published: April 2023

Background::
Calamintha nepeta is a plant from the Lamiaceae family that is known for its traditional use to treat diabetes among Algerian populations. However, till now, there has been no research work to confirm this activity.

Objectives::
This work aimed to evaluate the amylase inhibitory activity of essential oils and phenolic compounds from both methanolic and aqueous extracts of Algerian Calamintha nepeta (L.).

Methods::
The essential oil was obtained by hydrodistillation and analyzed using GC and then GC/MS. Aqueous and methanolic extracts were obtained from the remains of the hydrodistillation. Total phenolic compounds were quantified using the Folin-Ciocalteu method. The amylase inhibitory activity of the extracts was determined by testing their ability to inhibit alpha-amylase.

Results::
The extraction yield was 0.67 % (w/w) for the essential oil, and 11.85 and 4.38 % (w/w) for the aqueous and methanolic extracts, respectively. The essential oil analysis revealed that menthone, menthol, pulegone, and pulegone oxide were the main components of the oil. The total phenolic compounds in the aqueous and methanolic extracts were 41.81 and 32.92 mg GAE/g DW, respectively. The extracts inhibited α-amylase activity with IC50 values of 24.46, 31.54, and 115.47 mg/ml for the methanolic extract, essential oil, and aqueous extract, respectively.

Conclusion::
The different extracts of Calamintha nepeta showed an interesting composition and significant amylase inhibitory activity, emphasizing their successful use in traditional medicine.
In-silico Evaluation of Novel Honokiol Derivatives against Breast Cancer Target
Protein LKB1
Authors: Shahid Izzah , Shoaib Muhammad , Raza Rabail Zehra , Jahangir Muhammad , Abbasi Sumra Wajid , Riasat Areej , Akbar Ansa , Mehnaz Samina 
Published: April 2023

Background:
Breast cancer is characterized by uncontrolled cell growth in the breast tissue and is a leading
cause of death globally. Cytotoxic effects and reduced efficacy of currently used therapeutics insist to look for new
chemo-preventive strategies against breast cancer. LKB1 gene has recently been categorized as a tumor suppressor
gene where its inactivation can cause sporadic carcinomas in various tissues. Mutations in the highly conserved LKB1
catalytic domain lead to the loss of function and subsequently elevated expression of pluripotency factors in breast
cancer.

Objectives:
The utilization of drug-likeness filters and molecular simulation has helped evaluate the pharmacological
activity and binding abilities of selected drug candidates to the target proteins in many cancer studies.

Methods:
The current in silico study provides a pharmacoinformatic approach to decipher the potential of novel
honokiol derivatives as therapeutic agents against breast cancer. AutoDock Vina was used for molecular docking of the
molecules. A 100 nano second (ns) molecular dynamics simulation of the lowest energy posture of 3'-formylhonokiol-
LKB1, resulting from docking studies, was carried out using the AMBER 18.

Results:
Among the three honokiol derivatives, ligand-protein binding energy of 3' formylhonokiol with LKB1 protein
was found to be the highest via molecular docking. Moreover, the stability and compactness inferred for 3'-
formylhonokiol with LKB1 are suggestive of 3' formylhonokiol being an effective activator of LKB1 via simulation
studies.

Conclusion:
It was further established that 3'- formylhonokiol displays an excellent profile of distribution, metabolism,
and absorption, indicating it is an anticipated future drug candidate.
Modern Advancements, Patents and Applications of Futuristic
Nanozymes: A Comprehensive Review
Authors: Swain Suryakanta , Ghose Debashish , Jena Bikash Ranjan , Rao GSN Koteswara , Sahu Abhisek 
Published: April 2023

Abstract:
In the last few years, nanozymes have emerged as an adequate substitute for natural enzymes.
Recently, much attention has been paid to enzyme-mimic nanomaterials (nanozymes). Because of their
distinct characteristics, they are a critical alternative to natural enzymes that can be produced at a subordinate
cost and more efficiently. These nanomaterials have enzyme-like activity and have been cast off to
detect and treat biomolecules such as DNA, proteins, cells, and tiny molecules such as glucose. Hence,
the critical analysis of recent nanozyme is deemed essential for futuristic research, outcome-based results
specified to current trends of analytical tools, and several disease monitoring for targeted oncology therapies
like circulating tumor cells, MRI, PET, etc. In addition, the multivariate applications of nanozymes
for biosensors, immunoassay formation, tumor cell detection with earlier remedies, and environmentallysound
engineering technologies are discussed to climax the modern advancements. The novelty and originality
of this current review is to intensify the recent advancement, types and mimicking activity, biomedical
applications of nanozymes, implementation of the chemometric approach in nanozymes, and its futuristic
approach. Finally, to promote the understanding of nanozymes and the development of novel and
multifunctional nanozymes, we provide a comprehensive review of the nanozymes with their broadest
applications and modern technologies involved in targeted drug delivery, inventory with other diversified
arenas and existing patents indicating future implications.
L-Proline Catalyzed Organic Reactions via Microwave-Activation
Authors: Karmakar Rajiv , Mukhopadhyay Chhanda 
Published: April 2023

Abstract:In the past few years, using microwave power to heat and wield chemical reactions has be-come a gradually more popular subject in the scientific community. Microwave-supported organic syn-thesis is confirmed to be involved in rapidly synthesizing novel compounds with selectivity and en-hanced biological activities. Microwave flash heating for chemical synthesis is a spectacular reduction in reaction times, high yield and purity of the products, etc. A catalysis field wherein small organic mol-ecules like L-Proline efficiently and selectively catalyzes organic transformations. Microwave-assisted L-Proline catalyzed reactions are valuable tools for making different acyclic, heterocycles, and carbocy-clic scaffolds that signify the main framework of most bioactive compounds. In synthetic organic chem-istry, microwave irradiation speedily discarded the conventional heating methods in the world of multi-component and step-wise synthetic chemistry. This review discusses only L-Proline Catalyzed Organic Reactions under microwave activation using modern organic transformations, including condensation, addition, asymmetric, multi-components, and other modular reactions.
The Effect of Monetary Incentives on Health Care Social Media Content: Study Based on Topic Modeling and Sentiment Analysis
Authors: Maleki Negar , Padmanabhan Balaji , Dutta Kaushik 
Published: April 2023

Background
While there is high-quality online health information, a lot of recent work has unfortunately highlighted significant issues with the health content on social media platforms (eg, fake news and misinformation), the consequences of which are severe in health care. One solution is to investigate methods that encourage users to post high-quality content.

Objective
Incentives have been shown to work in many domains, but until recently, there was no method to provide financial incentives easily on social media for users to generate high-quality content. This study investigates the following question: What effect does the provision of incentives have on the creation of social media health care content?

Methods
We analyzed 8328 health-related posts from an incentive-based platform (Steemit) and 1682 health-related posts from a traditional platform (Reddit). Using topic modeling and sentiment analysis–based methods in machine learning, we analyzed these posts across the following 3 dimensions: (1) emotion and language style using the IBM Watson Tone Analyzer service, (2) topic similarity and difference from contrastive topic modeling, and (3) the extent to which posts resemble clickbait. We also conducted a survey using 276 Amazon Mechanical Turk (MTurk) users and asked them to score the quality of Steemit and Reddit posts.

Results
Using the Watson Tone Analyzer in a sample of 2000 posts from Steemit and Reddit, we found that more than double the number of Steemit posts had a confident language style compared with Reddit posts (77 vs 30). Moreover, 50% more Steemit posts had analytical content and 33% less Steemit posts had a tentative language style compared with Reddit posts (619 vs 430 and 416 vs 627, respectively). Furthermore, more than double the number of Steemit posts were considered joyful compared with Reddit posts (435 vs 200), whereas negative posts (eg, sadness, fear, and anger) were 33% less on Steemit than on Reddit (384 vs 569). Contrastive topic discovery showed that only 20% (2/10) of topics were common, and Steemit had more unique topics than Reddit (5 vs 3). Qualitatively, Steemit topics were more informational, while Reddit topics involved discussions, which may explain some of the quantitative differences. Manual labeling marked more Steemit headlines as clickbait than Reddit headlines (66 vs 26), and machine learning model labeling consistently identified a higher percentage of Steemit headlines as clickbait than Reddit headlines. In the survey, MTurk users said that at least 57% of Steemit posts had better quality than Reddit posts, and they were at least 52% more likely to like and comment on Steemit posts than Reddit posts.

Conclusions
It is becoming increasingly important to ensure high-quality health content on social media; therefore, incentive-based social media could be important in the design of next-generation social platforms for health information.
Development of Bacterial Cocktail of Strains Staphylococcus hominis, Staphylococcus warneri, Bacillus subtilis, and Micrococcus luteus as active ingredients for Skin Care Formula
Authors: Fathan Luthfi Hawari  , Tesya Almadea  , Karina Hananingsih  , Ahmad Baikuni  , Amarila Malik  , Arifianti Ayun Erwina , Ramadon Delly , Tjampakasari Conny Riana 
Published: April 2023

The microbial-based skin health care products that balance one's skin microbiome mimicking healthy skin are rapidly growing. Postbiotics gain more advantages in safety, shelf life, active peptides, and other active compounds such as GABA, which benefit human skin. We have isolated skin commensal bacteria, i.e., Staphylococcus hominis MBF12-19J, Staphylococcus warneri MBF02-19J, Micrococcus luteus MBF05-19J and Bacillus subtilis MBF10-19J in our previous study. This study aimed to make a formula of bacterial cocktail (BC) of those strains, elevate the BC formula into a ferment lysate (FL), and characterize the activities and test for skin sensitivity. The antibacterial activity was done by conducting a competition test using Propionibacterium acnes as an indicator bacterium, whereas the antioxidant activity assay was carried out using the DPPH method. The skin sensitivity was tested using the patch test method. The BC was lyzed by optimizing the enzymatic and ultrasonication methods, whereas sucrose was added as lyoprotectant to obtain a stable powder FL. Potential activity to inhibit P. acnes growth was achieved by a formula of FL consisting of M. luteus MBF05-19J: B. subtilis MBF10-19J: S. warneri MBF02-19J: S. hominis MBF12-19J in a ratio 1.5:1.5:0.5:0.5 or equivalent to DNA copy number/mL 1.01E+16: 1.14E+24: 1.96E+22: 1.50E+18. Skin sensitivity test results showed no sensitivity reaction, guaranteeing that CFS and FL are safe to use for the skin. Sucrose-FL at 12% sucrose formula showed higher physical stability than those without. However, the result of potential antioxidants showed mild and very mild activities compared to standard ascorbic acid.
TINJAUAN YURIDIS TERHADAP TRANSAKSI PERBANKAN MELALUI INTERNET BANKING DI INDONESIA
Authors: Pudyastiwi Elisabeth , Djatmiko Agoes 
Published: April 2023

Penelitian ini bertujuan untuk mengetahui, menganalisis, transaksi perbankan melalui internet banking di Indonesia. Penulisan artikel ini menggunakan metode penelitian bersifat yuridis normatif. Dalam pengumpulan data penelitian, dengan menggunakan bahan hukum sekunder berupa buku, jurnal, artikel, dan karya tulis lainnya, baik yang berasal dari media cetak maupun internet yang berhubungan dengan penelitian ini. Hasil penelitian menunjukan bahwa Internet banking merupakan salah satu pelayanan jasa bank yang memungkinkan nasabah untuk memperoleh informasi, melakukan komunikasi dan melakukan transaksi perbankan melalui jaringan internet. Transaksi perbankan melalui internet banking sampai saat ini belum diatur secara khusus dalam sistem perundang-undangan di Indonesia. Pengaturan mengenai transaksi perbankan melalui internet banking di Indonesia yang ada saat ini belum dapat menjamin kepastian hukum dan keadilan bagi para pihak, baik pihak bank maupun nasabah. Upaya perlindungan hukum telah dilakukan oleh pemerintah, namun substansi-substansi dari peraturan-peraturan yang ada belum menunjukkan adanya upaya perlindungan hukum yang optimal bagi para pihak.
Validation of the index for the core competence of nurses leading discharge planning for older patients in China†
Authors: Lu Lu , Ding Ling , Lu Hong-Yan , Lei Xin-Ning , Wu Zhen-Zhen , Zhang Rui 
Published: April 2023

Abstract

Objective
With the continuous advancement of aging in China, the number of older inpatients has increased sharply. Older patients have a high demand for planning their discharge services. Nurses serve as the leader of discharge planning for patients; there is a lack of reliable evaluation tool to evaluate the core competitiveness of nurses who implement discharge planning for older patients in China. The purpose of this study was to validate the index for the core competence of nurses who lead discharge planning for older patients developed by a project team through the Delphi method in the early stage.

Methods
A cross-sectional questionnaire survey with 3-stage stratified sampling was used to select 1075 nurses from 17 public general hospitals in Ningxia, China.

Results
The index consists of 4 first-level indicators, 13 second-level indicators, and 57 third-level indicators. The results show that 57 third-level indicators had good discrimination. With exploratory factor analysis (EFA), 4 common factors that explained 72.79% of the total variance were extracted. The Cronbach’s α was 0.98, and the retest reliability within a 14-d interval was 0.86. The confirmatory factor analysis (CFA) results show that the fit of the index structure was good. The criterion validity was 0.73.

Conclusions
The index presented excellent psychometric properties and can be used to measure the core competence of nurses in implementing discharge planning for older patients in China.
Evaluation of patient safety culture as perceived by nurses during the COVID-19 pandemic
Authors: Alabbas Anood M. , Althubyani Abdulhameid S. , Alfaki Mysara , Alharthi Faisal A. , AlKarani Ahmed 
Published: April 2023

Abstract

Objectives: A good patient safety culture (PSC) is linked to a reduced risk of patient problems and minimal undesirable occurrences. This study investigated the PSC levels from nurses’ perspectives during the COVID-19 pandemic.

Methods: A descriptive cross-sectional design was applied. The Hospital Survey on Patient Safety Culture (HSOPSC) questionnaire was administered to 315 nurses working at 2 major hospitals in Jeddah, Saudi Arabia. The data were analyzed using descriptive statistics, a t-test, and a one-way ANOVA test. The statistical significance of the correlation was determined at the 0.05 level.

Results: PSC was rated as medium overall according to the nurses, with a weighted mean of 2.88–0.76 and a relative weight of 57.57%. In addition, all PSC composites were rated from medium to high, except organizational learning, which was rated low. The correlation between sociodemographic variables as well as PSC levels was investigated using the t-test and one-way ANOVA test. The association is statistically significant when P ≤ 0.05. The findings revealed a statistically significant correlation between nurse nationality (t = −4.399, P = 0.000), age (F = 7.917, P = 0.000), experience in years (F = 3.760, P = 0.024), and hospital (t = −0.401, P = 0.689).

Conclusions: The nurses in this study had a medium overall PSC level, and all PSC composites ranged from a medium to a high level, except organizational learning, which had a low level. In addition, the findings showed that there is a significant relationship between PSC levels, nurses’ nationalities, experience in years, and the hospital itself.