bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward Probabilistic Post-Fire Debris-Flow Hazard Decision Support
Authors: Oakley Nina S. , Liu Tao , McGuire Luke A. , Simpson Matthew , Hatchett Benjamin J. , Tardy Alex , Kean Jason W. , Castellano Chris , Laber Jayme L. , Steinhoff Daniel 
Published: March 2023

Abstract
Post-wildfire debris flows (PFDF) threaten life and property in western North America. They are triggered by short-duration, high-intensity rainfall. Following a wildfire, rainfall thresholds are developed that, if exceeded, indicate high likelihood of a PFDF. Existing weather forecast products allow forecasters to identify favorable atmospheric conditions for rainfall intensities that may exceed established thresholds at lead times needed for decision-making (e.g., ≥24 h). However, at these lead times, considerable uncertainty exists regarding rainfall intensity and whether the high-intensity rainfall will intersect the burn area. The approach of messaging on potential hazards given favorable conditions is generally effective in avoiding unanticipated PFDF impacts, but may lead to “messaging fatigue” if favorable triggering conditions are forecast numerous times, yet no PFDF occurs (i.e., false alarm). Forecasters and emergency managers need additional tools that increase their confidence regarding occurrence of short-duration, high-intensity rainfall as well as tools that tie rainfall forecasts to potential PFDF outcomes. We present a concept for probabilistic tools that evaluate PFDF hazards by coupling a high-resolution (1-km), large (100-member) ensemble 24-h precipitation forecast at 5-min resolution with PFDF likelihood and volume models. The observed 15-min maximum rainfall intensities are captured within the ensemble spread, though in highest ∼10% of members. We visualize the model output in several ways to demonstrate most likely and most extreme outcomes and to characterize uncertainty. Our experiment highlights the benefits and limitations of this approach, and provides an initial step toward further developing situational awareness and impact-based decision-support tools for forecasting PFDF hazards.
Interaction of a Hysteresis Western Boundary Current with a Large-Scale Marginal Sea Circulation in a Gap-Leaping System
Authors: Mei Huan , Li Kunshan , Liu Qian , Wang Bin , Wu Xiangbai 
Published: March 2023

Abstract
The influence of a large-scale circulation (LSC) in a marginal sea on a hysteresis western boundary current (WBC) flowing across a gap is studied using a nonlinear 1.5-layer ocean model. Results show that both single-gyre LSC and double-gyre LSC are able to induce the critical-state WBC transition from the eddy-shedding regime to the leaping regime, while only double-gyre LSC is able to induce the critical-state WBC transition from the leaping regime to the eddy-shedding regime. The dynamics of WBC transition suggests that the meridional advection enhanced by the perturbation of the LSC is responsible for the regime shift from penetration to leap and that the meridional advection reduced by the perturbation of the LSC is responsible for the regime shift from leap to penetration. We also present the parameter space of the critical LSC that can induce the regime shift of WBC far away from the critical state. When the WBC is in the eddy-shedding regime, the critical strength of the single-gyre LSC increases as the WBC transport decreases regardless of the island’s presence in the gap. The critical strength of the double-gyre LSC increases as the WBC transport decreases in the no-island case, while the critical parameter increases as the WBC transport at first decreases and then increases in the island case. When the WBC is in the leaping regime, the critical strength of the double-gyre LSC increases as the WBC transport increases. These results help to explain the observed fact that the Kuroshio flows across the Luzon Strait in the leaping regime or the penetrating regime.
Predicting Early Versus Late In-Hospital Mortality in the Trauma Population
Authors: Dunitz Jackson , Rhodes Heather X. , Pepe Antonio P. 
Published: March 2023

This study aimed to evaluate non-survivors who were admitted to a level I trauma center but later died, in terms of predicting who would expire early vs late. This is a single-center study of Trauma Registry data, from July 3, 2016, to February 24, 2022. The inclusion criteria were based upon age (≥18 years) and in-hospital mortality. 546 patients (mean age 58) were included in the analysis. Trauma patients who may experience an earlier death were those with increasing injury severity scores, activation of massive transfusion protocol, comorbid advanced directive limiting care, COPD, personality disorder, and ED death location. Patients were more likely to experience later in-hospital mortality, including those with increasing ICU stays, and comorbid dementia.
Comparative analysis of the whole life carbon of three construction methods of a UK-based supermarket
Authors: Mohebbi Golnaz , Hasan Agha , Blay-Armah Augustine , Bahadori-Jahromi Ali , Mylona Anastasia , Barthorpe Mark 
Published: March 2023

The built environment has been a significant contributor to global carbon emissions. It, therefore, has a vital role to play in the reduction efforts of future climate change. While the design of buildings may determine future energy use for cooling, heating, and lighting during the operational stage of the building, this study aims to observe the effect of the building design on the operational as well as the whole-life carbon emissions. Past studies have focused on either the operational carbon or the embodied carbon of a building. Using a cradle-to-grave assessment of a typical UK supermarket, this study explores the relationship between embodied carbon and operational carbon. Additionally, it examines the effects of the variables between three approved construction methods of the same design on the whole life of carbon. These methods are a steel structural frame and cladding panel external wall, steel frame and poroton walls, precast concrete and glulam frame and precast concrete walls. The findings of this research will contribute to mitigation strategies for the environmental impacts of supermarket building construction whilst providing a framework for future assessment of the whole-life carbon of supermarket buildings. Employing the life cycle assessment methodology, this paper examines the potential of minimising both embodied and operational carbon by observing the whole life carbon. Highlighting the influence of the GHG emission contributing factors in each stage on each other. Additionally, the recommended methodology for the supermarket building types of this case study, could be adapted for other types of buildings. The findings could also augment carbon emission research and guide the development of supermarket buildings to low carbon intensive. Furthermore, collaboration with the industry in carrying out this research aids in adopting the findings as practical and theoretical guides for engineers and designers in reducing the building sector’s harmful environmental impact.
Clinical course and features of soft tissue sarcomas in geriatric patients: a single-center experience
Authors: Pehlivan Metin , İribaş Ayça , Bilgiç Bilge , Başaran Mert , Ekenel Meltem 
Published: March 2023

Objective This study was performed to examine the disease course in geriatric patients with soft tissue sarcoma and determine the risk factors for mortality. Methods We retrospectively analyzed patients who were treated at Istanbul University Oncology Institute from January 2000 to August 2021. Results Eighty patients were included in the study. The patients’ median age was 69 years (range, 65–88 years). The median overall survival of patients diagnosed between the ages of 65 and 74 years was 70 months, and that of patients diagnosed at the age of ≤75 years was significantly lower at 46 months. The median survival of patients who did and did not undergo surgical resection was 66 and 11 months, respectively, with a significant difference. The median overall survival of patients with positive and negative surgical margins was 58 and 96 months, respectively, also with a significant difference. Age at diagnosis and recurrence/metastasis significantly affected mortality. A 1-year increase in the age at diagnosis increased mortality by 1.147 times. Conclusion Age of >75 years, inability to undergo surgery, positive surgical margins, and head and neck location may be associated with a poor prognosis in geriatric patients with soft tissue sarcoma.
Direct and indirect costs for families of children with autism spectrum disorder in China
Authors: Zhao Yanan , Luo Yanan , Zhang Rong , Zheng Xiaoying 
Published: March 2023

Autism spectrum disorder has gained international attention due to its prevalence and the extent to which it can affect families. As a disorder without quantifiable treatment effects, it is easily overlooked in the battle for resources. Estimating family economic burdens and the specific factors that may be associated with them could help in the identification of resources and the promotion of social justice. We examined the family costs from a national family survey with Children with autism spectrum disorder aged 2–6 years ( N = 3236). A three-tiered model to quantify the costs was used. The families’ average annual direct cost per child was $24,869.0, including direct medical cost (inpatient, outpatient,drugs, etc.) of $6009.2 and direct nonmedical cost (rehabilitation or educational, rental, transportation, care, and others) of $18,859.8. The annual indirect costs (productivity loss from resignation and job adjustment) for families were $13,990.7. The total costs were $34,206.5. The results of the regression revealed that the mothers’ educational level was significantly associated with costs. Families with an interprovincial immigration background, a higher-than-average income, or children with more severe autism spectrum disorder had a greater possibility of higher direct, indirect, and overall costs. Autism spectrum disorder imposed a significant financial burden on the families of children with autism spectrum disorder. Lay abstract This is the first comprehensive national study to explore the direct and indirect costs for families of children with autism spectrum disorder in China. The increasing prevalence of autism spectrum disorder highlights a growing need for resources to provide care for families of children with autism spectrum disorder. The medical and nonmedical costs and parents’ productivity loss have caused a serious burden on their families. Our objective is to estimate the direct and indirect costs for the families of children with autism spectrum disorder in China. The target population was parents of children with autism spectrum disorder. We analyzed the costs using cross-sectional data from a Chinese national family survey with children aged 2–6 years ( N = 3236) who were clinically diagnosed with autism spectrum disorder. Family data from 30 provinces in China were obtained. Cost items included direct medical costs, direct nonmedical costs, and indirect costs. In this study, we found that the largest part of family costs for autism spectrum disorder are nonmedical costs and productivity loss. Autism spectrum disorder has imposed a huge economic burden on parents having children with autism spectrum disorder in China, who need more support than the current health care system provides.
Contrast-Associated Acute Kidney Injury in High-Risk Patients Undergoing Peripheral Vascular Interventions
Authors: Locham Satinderjit , Rodriguez Alejandra , Balceniuk Mark D , Mix Doran , Newhall Karina , Doyle Adam , Glocker Roan , Ellis Jennifer , Stoner Michael 
Published: March 2023

Objective: This study aims to evaluate the use of prophylactic intravenous hydration (IV prophylaxis) and carbon dioxide (CO2) angiography in reducing contrast associated-acute kidney injury (CA-AKI) and determine the overall incidence and risk factors of CA-AKI in high-risk patients undergoing peripheral vascular interventions (PVI). Method: Only patients undergoing elective PVI from 2017 to 2021 with chronic kidney disease (CKD) stage 3-5 in the Vascular Quality Initiative (VQI) database were included. Patients were grouped into IV prophylaxis vs no prophylaxis. The study’s primary outcome was CA-AKI, defined as a rise in creatinine (>.5 mg/dL) or new dialysis within 48 hours following contrast administration. Standard univariate and multivariable (logistic regression) analyses were conducted. Results: A total of 4497 patients were identified. Of these, 65% received IV prophylaxis. The overall incidence of CA-AKI was .93%. No significant difference was seen in overall contrast volume (mean (SD): 66.89(49.54) vs 65.94(51.97) milliliters, P > .05) between the 2 groups. After adjusting for significant covariates, the use of IV prophylaxis (OR (95% CI): 1.54(.77-3.18), P = .25) and CO2 angiography (OR (95%CI): .95(.44-2.08), P = .90) was not associated with a significant reduction in CA-AKI compared to the patients with no prophylaxis. The severity of CKD and diabetes were the only predictor of CA-AKI. Compared to patients with no CA-AKI, patients with CA-AKI were at risk of higher 30-day mortality (OR (95% CI): 11.09 (4.25-28.93)) and cardiopulmonary complications (OR (95% CI): 19.03 (8.74-41.39) following PVI (Both P < .001). Conclusion: Using a large national vascular database, our study demonstrates that prophylactic use of IV hydration and CO2 angiography in high-risk CKD patients is not associated with a reduction in renal injury following PVI. Reduced kidney function and history of diabetes is an independent predictor of CA-AKI and patients that develop post-procedural AKI are at an increased risk of morbidity and mortality.
Glyphosate affects persistence and tolerance but not antibiotic resistance
Authors: Ospino Katia , Spira Beny 
Published: March 2023

AbstractGlyphosate is a herbicide widely used in food production that blocks the synthesis of aromatic amino acids in plants and in microorganisms and also induces the accumulation of the alarmone (p)ppGpp. The purpose of this study was to investigate whether glyphosate affects the resistance, tolerance or persistence of bacteria towards three different classes of antibiotics and the possible role of (p)ppGpp in this activity. Glyphosate did not affect the minimum inhibitory concentration of the tested antibiotics, but enhanced bacterial tolerance and/or persistence towards them. The upshift in ciprofloxacin and kanamycin tolerance was partially dependent on the presence of relA that promotes (p)ppGpp accumulation in response to glyphosate. Conversely, the strong increase in ampicillin tolerance caused by glyphosate was independent of relA. We conclude that by inducing aromatic amino acid starvation glyphosate contributes to the temporary increase in E. coli tolerance or persistence, but does not affect antibiotic resistance.
Cooling spray or lidocaine spray and needle insertion pain in hemodialysis patients: an open-label cross-over randomized clinical trial
Authors: Khosravi Pour Armin , Hejazi Sima , Kameli Ahmad , Hoseini Azizi Tooba , Armat Mohammad Reza , Eshghi Maesoomeh 
Published: March 2023

Abstract
Background
The needle insertion pain to perform hemodialysis is the main challenge and a common problem that requires pain management techniques for patients’ comfort.

Aim
This study aimed to compare the effects of cooling and lidocaine sprays on needle insertion pain in hemodialysis patients.

Methods
In this randomized cross-over clinical trial study, the hemodialysis patients were selected through convenience sampling according to inclusion criteria and randomly assigned to three intervention groups using the block randomization method. Each patient received three interventions in a cross-over design: Cooling spray or 10% lidocaine spray or placebo spray. There was a 2-week wash-out time between each intervention. The pain score was measured four times for each patient by the Numerical Rating Scale.

Results
Forty-one hemodialysis patients were included. The results showed a significant interaction between time and group (p < 0.05), so only observations of time 1 with adjustment for baseline values were used to evaluate the effect of the intervention. Patients receiving cooling spray reported 2.29 less pain score on average compared to placebo (B=-2.29, 95% CI: -4.17 to -0.43; p < 0.05); Also, patients receiving cooling spray reported a 1.61 lower pain score than those receiving lidocaine spray, but this difference was not statistically significant (95% CI: -0.26 to 3.48; p > 0.05).

Conclusion
The cooling spray was effective in reducing the needle insertion pain. Although it was impossible to compare the pain scores at different times and following different interventions, the present study results can help supplement the existing knowledge regarding cooling and lidocaine sprays.
Safer cycling in older age (SiFAr): effects of a multi-component cycle training. a randomized controlled trial
Authors: Keppner Veronika , Krumpoch Sebastian , Kob Robert , Rappl Anja , Sieber Cornel C. , Freiberger Ellen , Siebentritt Hanna Maria 
Published: March 2023

Abstract
Background
The risk of older adults being injured or killed in a bicycle accident increases significantly due to the age-related decline of physical function. Therefore, targeted interventions for older adults to improve safe cycling competence (CC) are urgently needed.

Methods
The “Safer Cycling in Older Age” (SiFAr) randomized controlled trial investigated if a progressive multi-component training program related to cycling improves CC of older adults. Between June 2020 and May 2022, 127 community-dwelling persons living in the area Nürnberg-Fürth-Erlangen, Germany aged 65 years and older were recruited, who are either (1) beginners with the e-bike or (2) feeling self-reported unsteadiness when cycling or (3) uptaking cycling after a longer break. Participants were either randomized 1:1 to an intervention group (IG; cycling exercise program, 8 sessions within 3 months) or an active control group (aCG; health recommendations). The CC as primary outcome was tested not blinded in a standardized cycle course prior and after the intervention period and after 6–9 months, which consists of variant tasks requiring skills related to daily traffic situations. Regression analyses with difference of errors in the cycling course as dependent variable and group as independent variable adjusted for covariates (gender, number of errors at baseline, bicycle type, age and cycled distance) were performed.

Results
96 participants (73.4 ± 5.1 years; 59.4% female) were analyzed for primary outcome. Compared to the aCG (n = 49), the IG (n = 47) made an average of 2.37 fewer errors in the cycle course after the 3 months intervention period (p = 0.004). People with more errors at baseline had higher potential for improvement (B=-0.38; p < 0.001). Women on average made 2.31 (p = 0.016) more errors than men, even after intervention. All other confounders had no significant effect on the difference in errors. The intervention effect was very stable until 6–9 months after the intervention (B=-3.07, p = 0.003), but decreased with a higher age at baseline in the adjusted model (B = 0.21, p = 0.0499).

Conclusion
The SiFAr program increases cycling skills among older adults with self-perceived needs for improvement in CC and could easily be made available to a broad public due to its standardized structure and a train-the-trainer approach.

Trial Registration
This study was registered with clinicaltrials.gov: NCT04362514 (27/04/2020), https://clinicaltrials.gov/ct2/show/NCT04362514.
Clinical characteristics and outcomes of children with single or co-detected rhinovirus-associated acute respiratory infection in Middle Tennessee
Authors: Amarin Justin Z. , Potter Molly , Thota Jyotsna , Rankin Danielle A. , Probst Varvara , Haddadin Zaid , Stewart Laura S. , Yanis Ahmad , Talj Rana , Rahman Herdi , Markus Tiffanie M. , Chappell James , Lindegren Mary Lou , Schaffner William , Spieker Andrew J. , Halasa Natasha B. 
Published: March 2023

Abstract
Background
Rhinovirus (RV) is one of the most common etiologic agents of acute respiratory infection (ARI), which is a leading cause of morbidity and mortality in young children. The clinical significance of RV co-detection with other respiratory viruses, including respiratory syncytial virus (RSV), remains unclear. We aimed to compare the clinical characteristics and outcomes of children with ARI-associated RV-only detection and those with RV co-detection—with an emphasis on RV/RSV co-detection.

Methods
We conducted a prospective viral surveillance study (11/2015–7/2016) in Nashville, Tennessee. Children < 18 years old who presented to the emergency department (ED) or were hospitalized with fever and/or respiratory symptoms of < 14 days duration were eligible if they resided in one of nine counties in Middle Tennessee. Demographics and clinical characteristics were collected by parental interviews and medical chart abstractions. Nasal and/or throat specimens were collected and tested for RV, RSV, metapneumovirus, adenovirus, parainfluenza 1–4, and influenza A–C using reverse transcription quantitative polymerase chain reaction assays. We compared the clinical characteristics and outcomes of children with RV-only detection and those with RV co-detection using Pearson’s χ2 test for categorical variables and the two-sample t-test with unequal variances for continuous variables.

Results
Of 1250 children, 904 (72.3%) were virus-positive. RV was the most common virus (n = 406; 44.9%), followed by RSV (n = 207; 19.3%). Of 406 children with RV, 289 (71.2%) had RV-only detection, and 117 (28.8%) had RV co-detection. The most common virus co-detected with RV was RSV (n = 43; 36.8%). Children with RV co-detection were less likely than those with RV-only detection to be diagnosed with asthma or reactive airway disease both in the ED and in-hospital. We did not identify differences in hospitalization, intensive care unit admission, supplemental oxygen use, or length of stay between children with RV-only detection and those with RV co-detection.

Conclusion
We found no evidence that RV co-detection was associated with poorer outcomes. However, the clinical significance of RV co-detection is heterogeneous and varies by virus pair and age group. Future studies of RV co-detection should incorporate analyses of RV/non-RV pairs and include age as a key covariate of RV contribution to clinical manifestations and infection outcomes.