bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanocomposite Hydrogels: An Optimistic Insight Towards the Treatments of Ocular Disorders
Authors: Shah Shailvi , Patel Riya , Patel Gayatri 
Published: July 2023

Background:
The distinct anatomy and physiology of the eye represent it as a specialized organ.
The noumenal physiological barriers, whose prominent role is to prevent the entrance of extracellular
substances, reduce the bioavailability of medicines taken locally. Nanocarriers offer many advantages,
such as site-specific drug delivery, reduced dose-related side effects, more drug loading capacity,
etc. Nanoparticles, nano micelles, Nanostructured Lipid Carriers (NLCs), Solid Lipid Nanoparticles
(SLNs), liposomes, polymeric nanoparticles, microspheres, microemulsions, etc., have all undergone
significant analysis to overcome numerous static and dynamic obstacles.

Objective:
Among the several methods of delivering drugs, one of the most captivating and demanding
is ocular drug delivery (ODD). The intent of developing formulations for an extended period can be partially
achieved via thermoresponsive hydrogels. It is feasible to store fluids inside a cross-linked gel system
for efficient long-term administration owing to hydrogels, which are hydrophilic polymeric networks
with excellent three-dimensional structures and water or biological fluid absorption capacities.
Hydrogels can be incorporated into nanocarriers to achieve site-specific action and prolonged release.

Methods:
Related patents and research reports with various platforms like Science Direct, Springer,
PubMed, Google Scholar, Shodhganga, and Patseer were used to gather the data, and a search methodology
was availed.

Results:
The paper thoroughly summarizes the strategies for incorporating drugs with hydrogel into a
nanocarrier to provide sustained release and prolonged therapeutic effects. According to the comprehensive
review of literature and patents like (US2015374633A1), (US10980882B2), and
(WO2011018800A2), nanocarrier-loaded thermoresponsive hydrogels show promising results.

Conclusion:
Due to their propensity to alter state in reaction to temperature changes, thermoresponsive
hydrogels can improve medication bioavailability. Intervening nanocarriers loaded hydrogels directly
on the targeted site displays local intervention and site-specificity. Thus, the use of nanocarriers in ocular
drug delivery is encouraging.
Doping Induced Optical Band Gap Modification of Potassium
Dihydrogen Phosphate
Authors: Padmanabhan Vijeesh , Majeed Muneer Erikad , Kizhakkethil Shifa , Vijayakumar Arjun , Rajachandran Vineeth 
Published: July 2023

Aim:
Potassium dihydrogen phosphate (KDP) is an excellent nonlinear optical
material that has many potential applications, such as laser frequency conversion, Qswitches,
Pockels cells, 3-D optical data storage devices, etc. Doping enhances various optical
parameters of KDP. Doping changes in the absorbance and dopants such as aspartic
acid, succinic acid, glycine, and L-alanine improved the optical band gap of the sample.

Background:
KDP is a non-linear optic material that has many important applications.
Many researchers all over the world are trying to improve its optical properties.

Objective:
To synthesise pure KDP and KDP doped with aspartic acid, succinic acid, glycine,
and L-alanine. Also, to study the temperature stability of the grown samples using
TGA, DTA, and DSC analysis,

Method:
Growth from solution at low temperatures is used for the growth of crystals.
TGA, DTA, and DSC are used to analyse the stability of the samples against temperature
variations.

Results:
KDP crystals of good quality were grown using the slow cooling solution growth
technique. Determined their band gap using the Tauc Plot. Significant variations in the optical
bandgap are noticed. Also, the TGA, DTA, and DSC characterizations were done.

Conclusion:
KDP solution and grown crystals of good quality were synthesized. The variation
in the bandgap on doping is a significant result as the modifications in bandgap enable
the sample to be used in a more enhanced applications. Also, the doped samples were
stable for variations in temperature, like the pure KDP.
A Comparative Study: Modisco and Acupressure for Weight Gaining Toddler
Authors: Widowati Hesty , Hanum SMF , Widanti Herista Novia , Rizqiyah Mar`Ati Amalia 
Published: July 2023

<p><strong>Background:</strong> Inappropriate practice of feeding and complementary foods is one of the causes of malnutrition in children in Indonesia. Providing additional food such as Modisco (Modified Dietetic Skimmed Milk and Coconut Oil) can be an effort to improve the nutritional status of toddlers, besides acupressure therapy can increase appetite so that it can increase the child's weight.</p><p><strong>Objective:</strong> This study aims to determine the difference in the effectiveness of the combination of Modisco and acupressure with only Modisco on increasing toddler’s weight.</p><p><strong>Methods:</strong> This study used a Quasy Experiment group design with a Pre and Post Test Control Group Design approach. The inclusion criteria were children aged 1-5 years, included in the thin category and did not have heart, liver, and kidney disease. The sample was selected by purposive sampling as many as 30 toddlers who were divided into 2 groups with the provision that group I amounted to 15 toddlers were given complementary foods made from modisco II for 14 days and acupressure 6 times (2 times a week for 3 weeks), while group II amounted to 15 toddlers are only given complementary foods made from modisco II for 14 days. Statistical test using Paired sample T Test.</p><p><strong>Results:</strong> In group I, there was a difference in the average weight of children under five before and after the intervention with p value = 0.001 (p &lt; 0.005), meaning that the combination of modisco and acupressure can increase body weight in toddlers. In group II, there was a difference in the average weight of children under five before and after the intervention with a p value = 0.003 (p &lt; 0.005), which means that modisco can increase body weight in toddlers.</p><p><strong>Conclusion:</strong> From the results of the difference in the average weight of group I and group II with a value of p = 0.013, it means that there is no significant difference between the groups given the combination of modisco plus acupressure and the modisco group on the weight gain of toddlers.</p>
Preference Elicitation and Treatment Decision-Making Among Men Diagnosed With Prostate Cancer: Randomized Controlled Trial Results of Healium
Authors: Diefenbach Michael A , Marziliano Allison , Tagai Erin K , Pfister Halie , Lapitan Emmanuel , Hall Simon J , Vira Manish , Ibrahim Said , Aibel Kelli , Kutikov Alexander , Horwitz Eric M , Miyamoto Curtis , Reese Adam C , Miller Suzanne M 
Published: July 2023

Background
Elicitation of patients’ preferences is an integral part of shared decision-making, the recommended approach for prostate cancer decision-making. Existing decision aids for this population often do not specifically focus on patients’ preferences. Healium is a brief interactive web-based decision aid that aims to elicit patients’ treatment preferences and is designed for a low health literate population.

Objective
This study used a randomized controlled trial to evaluate whether Healium, designed to target preference elicitation, is as efficacious as Healing Choices, a comprehensive education and decision tool, in improving outcomes for decision-making and emotional quality of life.

Methods
Patients diagnosed with localized prostate cancer who had not yet made a treatment decision were randomly assigned to the brief Healium intervention or Healing Choices, a decision aid previously developed by our group that serves as a virtual information center on prostate cancer diagnosis and treatment. Assessments were completed at baseline, 6 weeks, and 3 months post baseline, and included decisional outcomes (decisional conflict, satisfaction with decision, and preparation for decision-making), and emotional quality of life (anxiety/tension and depression), along with demographics, comorbidities, and health literacy.

Results
A total of 327 individuals consented to participate in the study (171 were randomized to the Healium intervention arm and 156 were randomized to Healing Choices). The majority of the sample was non-Hispanic (272/282, 96%), White (239/314, 76%), married (251/320, 78.4%), and was on average 62.4 (SD 6.9) years old. Within both arms, there was a significant decrease in decisional conflict from baseline to 6 weeks postbaseline (Healium, P≤.001; Healing Choices, P≤.001), and a significant increase in satisfaction with one’s decision from 6 weeks to 3 months (Healium, P=.04; Healing Choices, P=.01). Within both arms, anxiety/tension (Healium, P=.23; Healing Choices, P=.27) and depression (Healium, P=.001; Healing Choices, P≤.001) decreased from baseline to 6 weeks, but only in the case of depression was the decrease statistically significant.

Conclusions
Healium, our brief decision aid focusing on treatment preference elicitation, is as successful in reducing decisional conflict as our previously tested comprehensive decision aid, Healing Choices, and has the added benefit of brevity, making it the ideal tool for integration into the physician consultation and electronic medical record.

Trial Registration
ClinicalTrials.gov NCT05800483; https://clinicaltrials.gov/study/NCT05800483
Bienestar mental, sentido de coherencia y factores sociodemográficos en médicos residentes de medicina familiar
Authors: Ramos-Valle David , Saucedo-Martínez María Guadalupe , Muñoz-Reyna Pedro Alberto 
Published: July 2023

Introducción: La Organización Mundial de la Salud considera que la universidad debe ser un espacio social en el que se promueva la salud para mejorar o prevenir enfermedades en la comunidad escolar. En los diversos escenarios clínico-educativos en los cuales los médicos residentes realizan su especialización ocurren situaciones que trasgreden su salud física y mental. El sentido de coherencia es su capacidad para percibir que son competentes y manejar cualquiera de estas situaciones, independientemente de lo que suceda en su vida, es una habilidad para seleccionar el estilo de afrontamiento que mejor se ajuste a una situación dada.
Objetivo: Determinar la relación entre bienestar mental, sentido de coherencia y factores sociodemográficos de interés en médicos residentes de la especialidad en medicina familiar adscritos a una unidad de medicina familiar.
Método: Se ejecutó estudio predictivo transversal, en el que previo consentimiento informado participaron médicos residentes de la especialidad en medicina familiar, se recuperaron factores sociodemográficos, se midió su sentido de coherencia y bienestar mental auto aplicando instrumentos válidos y confiables. Mediante un modelo lineal generalizado se estimó la relación entre estas variables ajustándose por grado académico, se consideró valores p ≤ 0.05 como estadísticamente significativos.
Resultados: Sentido de coherencia se asoció significativamente con bienestar mental (B = 0.223, IC 95% [0.137, 0.309], p = 0.000), en residentes de primer grado (B = –7.573, IC 95% [–12.637, –2.508], p = 0.003) y en residentes de segundo grado (B = –6.336, IC 95% [–11.925, –0.748], p = 0.026). El análisis de devianza (D2 = 0.6427) indica que sentido de coherencia y grado académico revelan 64% de la variabilidad de bienestar mental.
Conclusiones: El sentido de coherencia tuvo una relación significativa con el bienestar mental en médicos residentes de la especialidad en medicina familiar; por ello, intervenciones orientadas a favorecer el sentido de coherencia pueden diseñarse y utilizarse para mitigar su bienestar mental.
Aprendizaje Basado en Problemas: Una experiencia curricular con estudiantes del internado de Ginecología
Authors: Vargas-Vera Ramón Miguel , Placencia-Ibadango Martha Verónica , Placencia-Ibadango Silvia Maribel , Vargas-Silva Kalid Stefano , Alencastro-Placencia Saúl Alexander 
Published: July 2023

Introducción: Algunas universidades buscan mejorar la enseñanza en la carrera de medicina, el aprendizaje basado en problema es una alternativa que desplazaría al sistema tradicional.
Objetivo: Describir la experiencia educativa y satisfacción de los estudiantes con la aplicación del aprendizaje basado en problema (ABP) en un semestre del internado de medicina del año 2022 en la asignatura de ginecología y obstetricia.
Método: Estudio transversal descriptivo a través de la aplicación de una encuesta, se tomó una muestra aleatoria de 150 estudiantes de una población de 450 internos pertenecientes a la Universidad de Guayaquil, Facultad de Medicina, cursando Ginecología-Obstetricia del internado rotativo. Para la recolección de la información, se aplicaron técnicas de investigación e instrumentos de recolección, tanto para información primaria como secundaria.
Resultados: Esta estrategia permitió que los estudiantes estén activos, críticos y profundicen los conocimientos adquiridos previamente, de acuerdo a las encuestas planteadas al final de las clases presentaron 80% de satisfacción por esta estrategia.
Conclusiones: La estrategia de enseñanza permitió que los internos de medicina tengan una participación más activa, cooperativa y critica que estuvieron centradas en el estudiante; demostrada por el porcentaje de satisfacción y apoyo en las dificultades presentadas por el docente.
OBSOLESCENCIA DE LA BIPARTICIÓN CIVIL LAW - COMMON LAW: GESTACIÓN DE NUEVOS MODELOS PROCESALES CIVILES ¿REALIDAD O UTOPÍA?
Authors: Vieyra Luna Evelyn 
Published: July 2023

El objetivo principal de este artículo es presentar brevemente la historia, características y diferencias de los tradicionales modelos procesales: el common law y el civil law a fin de demostrar su obsolescencia y quiebre. Para estos efectos, se ha empleado el método funcional, propio del derecho comparado, en el entendido que se busca comparar el medio por el cual el common law y el civil law, resuelven sus conflictos de relevancia jurídica, esto es, el “proceso”, a través de la identificación sucinta de los rasgos esenciales de cada uno de ellos, diferenciándoles de elementos variables, mediante la constatación de normativa relevante (histórica y vigente) como de la verificación de las diversas posiciones dogmáticas básicas que han personificado a dichos modelos procesales. El resultado ha sido la comprobación de que en la actualidad los sistemas mixtos se asoman como una realidad más común de lo que pareciera.
Pemberdayaan Peternak Milenial: Strategi dan Dampak
Authors: Afifudin Fauzi Nur , Purwanto Danang , Ghufronuddin Ghufronuddin 
Published: July 2023

Ngargosari Village is undertaken in an effort to enhance community capabilities. This article aims to comprehend the implementation of empowerment strategies for millennial farmers and their impacts. The research methodology utilized is qualitative with a case study approach, employing data collection techniques through interviews and observations. This study showed that the implementation of empowerment strategies by Komunitas Ternak Lembu Mukti involves five main activities, namely plegung, regular arisan (rotating credit association), a savings and loan system for initial capital, the principle of 3 M (Self-Management, Financial Management, and time management), and the provision of land facilities by the village. These activities have had a positive impact on the members of the community and society at large, leading to enhanced livestock management skills, productivity, and welfare. This study concludes that the implementation of empowerment strategies for millennial farmers has yielded positive outcomes in terms of enhancing capabilities, productivity, and the welfare of the community. Furthermore, the strategies align with the principles of the ACTORS theory, as they grant communities the freedom to leverage local potential with the support of external actors as empowering agents.
AbstrakPemberdayaan peternak milenial oleh Komunitas Ternak Lembu Mukti di Desa Ngargosari dilakukan sebagai upaya meningkatkan kemampuan masyarakat. Penelitian ini bertujuan untuk memahami penerapan strategi pemberdayaan peternak milenial serta dampaknya. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan studi kasus dengan teknik penugumpulan data melalui wawancara dan observasi. Hasil penelitian menunjukkan bahwa penerapan strategi pemberdayaan oleh Komunitas Ternak Lembu Mukti melibatkan lima kegiatan utama, yaitu plegung, arisan rutin, sistem simpan pinjam untuk modal awal, prinsip 3 M (Manajemen Diri, Manajemen Keuangan, Manajemen Waktu), serta fasilitas lahan yang diberikan oleh desa. Kegiatan-kegiatan tersebut memberikan dampak positif pada anggota komunitas dan masyarakat, meningkatkan kemampuan mengelola ternak, produktivitas, dan kesejahteraan. Kajian ini menyimpulkan bahwa penerapan strategi pemberdayaan peternak milenial berdampak positif dalam meningkatkan kemampuan, produktivitas, dan kesejahteraan masyarakat serta sesuai dengan konsep teori ACTORS yang memberikan kebebasan kepada masyarakat untuk memanfaatkan potensi lokal dengan dukungan pihak lain sebagai pemberi daya.
O ensino de língua portuguesa e os universais musicais: uma amostragem de prática interpretativa
Authors: Silva Emanuela Francisca Ferreira , Mari Hugo 
Published: July 2023

Esse trabalho é parte de um projeto de pesquisa desenvolvido em doutoramento em Língua Portuguesa eLínguística do Programa de Pós-graduação em Letras da PUC Minas, que visa compreender e discutir a utilização dos universais musicais – ritmo e melodia – como ferramentas no ato interpretativo de um texto, potencializando a compreensão do mesmo. A interpretação textual é uma prática de linguagem. O trabalho de compreender um texto ultrapassa o domínio do sujeito comunicante e do sujeito interpretante. Patrick Chauredau (2008) afirma que a encenação discursiva é condição primordial para comunicação. Segundo Chauredeau (2008) o ato de linguagem é composto de vários sujeitos – Euc - EUe/ Tui -TUd – e que comunicar é proceder a uma encenação. Para este trabalho pretende-se limitar a pesquisa a dois desses sujeitos comunicantes, respectivamente: TUi-TUd, encenados pelo sujeito interpretante no ato comunicativo. Pretende-se apresentar uma parte dessa pesquisa que tem por eixo as abordagens experencialista e corporificada, afirmando que a construção de sentido depende da interação de trêsdimensões: cérebro, corpo em ação e interação organismo-ambiente. Tem-se a hipótese de que ao utilizar dos universais musicais no ato da interpretação TUi-TUd constroem-se esquemas imagéticos, por meio dos quais TUi-TUd experencia o mundo. Para tanto, baseia-se na Teoria da Integração Experencial (AUCHLIN, 2003) em que se integram dois espaços de entrada: o experencial sensório-motor e a elaboração linguística e o Modelo Semiótico de Brandt (2005), em que o espaço-base é discursivo, pois é construído a partir do “ato de dizer e aquilo que é dito”. Tentar-se-á integrar ambos os modelos para apresentar um modelo próprio de análise e confirmar a hipótese que rege esse trabalho.
Uma proposta de ensino-aprendizagem da ortografia do português brasileiro
Authors: Guimarães Fernanda Taís Brignol , De Oliveira Vinícius Oliveira 
Published: July 2023

uscamos, neste artigo, avaliar o desempenho ortográfico de uma criança de 09 anos de idade, aluna do 3º ano do ensino fundamental de uma escola pública do município de Bagé/RS. Para tanto, nos valemos dos estudos de Morais (2008) e da aplicação do roteiro de observação ortográfica, proposta por Zorzi (1998). Ao final do trabalho, propomos uma atividade de intervenção pedagógica, a qual visa intervir de forma sistematizada no aprendizado da aluna, auxiliando-a na compreensão do funcionamento do sistema ortográfico brasileiro.
COVID-19 Pneumonia in Pregnancy: A Retrospective Study on Maternal and Neonatal Outcomes
Authors: Benlghazi Abdelhamid , Moad Belouad , Dabdi Hanane , Yassine Bouhtouri , Hamza Messaoudi , Saad Benali , rachid Ait Bouhou , Fatima El mangoub , Mehdi Elhassani Mly El , Jaouad Kouach 
Published: July 2023

Objective: To identify risk factors among pregnant with COVID-
19 for adverse outcomes related to disease severity, maternal
morbidities, neonatal mortality and morbidity, and adverse birth
outcomes. Materials and methods: In this retrospective study,
45 pregnant patients with COVID-19 pneumonia confirmed by RT-PCR were
evaluated at HMIMV. The inclusion criteria were pregnant patients
diagnosed with COVID-19 confirmed by RT-PCR and hospitalized in the
gynecology-obstetrics and intensive care unit at Mohammed V Military
Training Hospital (HMIMV). Exclusion criteria were non-pregnant patients
and pneumonia cases with unconfirmed COVID-19 cause. Data was collected
from patient records and telephone calls. The study used SPSS
software to analyze the data. Results: Our study recorded 45
cases of SARS-CoV-2 infection in pregnant women over 2.5 years in the
gynecology-obstetrics department at HMIMV. The age group most affected
was 20-35 years, with 75% of cases. 57% of patients had no known
comorbidities. 88.8% of patients were symptomatic at diagnosis, with
fever, asthenia, headache, myalgia, anosmia, and ageusia being the most
common symptoms. Almost 30% of patients required admission to the ICU,
with 60% requiring oxygen supplementation. The study recorded 36 live
births (80%), of which 26 cases (72.2%) required no further care and
had a favorable outcome. Conclusion: Severe acute respiratory
distress syndrome, which can be fatal, is a significant risk associated
with COVID-19. Pregnant women with underlying medical conditions are
more vulnerable to this complication and may benefit from preventive
measures, such as lockdowns, to reduce their risk of infection. The
severity of maternal disease appears to have an impact on obstetrical
and neonatal outcomes, with potential complications including cesarean
sections, neonatal prematurity, and admission to the intensive care unit
.