bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catching Dory: Selling Aquarium Fish Supports Coastal Livelihoods in Indonesia
Authors: Swanson S. S. , Gutierrez E. , Moore A. M. , Souza T. , Ndobe S. , Jompa J. , Crowder L. B. 
Published: March 2023

Abstract
The global marine aquarium trade has created new local markets across the planet, including in Indonesia, now the second largest exporting country of marine aquarium fish in the world. Participating in the global aquarium trade has been touted as a potentially sustainable addition to fisher livelihoods, but scant data exist showing the numbers of fish coming off the reef and how those fish contribute to income. To determine how small-scale fishers and traders incorporate aquarium species in their livelihoods, we examine source-level aquarium fish collecting and trading data in the Banggai Archipelago, a region in Central Sulawesi that has become a significant source for popular aquarium fishes. From one year of buying and selling data at the fisher, intermediary buyer, and regional trader levels we show that catching and selling fish for the aquarium trade represents an average of nearly 20% of annual income and provides added diversity and flexibility to fisher and trader livelihoods in the region, especially during seasons of rough weather.
Development of VHL-recruiting STING PROTACs that suppress innate immunity
Authors: Zhu Zhichuan , Johnson Rebecca L. , Zhang Zhigang , Herring Laura E. , Jiang Guochun , Damania Blossom , James Lindsey I. , Liu Pengda 
Published: March 2023

Abstract
STING acts as a cytosolic nucleotide sensor to trigger host defense upon viral or bacterial infection. While STING hyperactivation can exert anti-tumor effects by increasing T-cell filtrates, in other contexts hyperactivation of STING can contribute to autoimmune and neuroinflammatory diseases. Several STING targeting agonists and a smaller subset of antagonists have been developed, yet STING targeted degraders, or PROTACs, remain underexplored. Here, we report a series of STING-agonist derived PROTACs that promote STING degradation in renal cell carcinoma (RCC) cells. We show that our STING PROTACs activate STING and target activated/phospho-STING for degradation. Locking STING on the endoplasmic reticulum via site-directed mutagenesis disables STING translocation to the proteasome and resultingly blocks STING degradation. We also demonstrate that PROTAC treatment blocks downstream signaling events and attenuates the anti-viral response. Interestingly, we find that VHL acts as a bona fide E3 ligase for STING in RCC; thus, VHL-recruiting STING PROTACs further promote VHL-dependent STING degradation. Our study reveals the design and biological assessment of VHL-recruiting agonist-derived STING PROTACs, as well as demonstrates an example of hijacking a physiological E3 ligase to enhance target protein degradation.
Spectral graph modeling reveals global slowing of neurophysiological network transmission in Alzheimer’s disease
Authors: Verma Parul , Ranasinghe Kamalini , Prasad Janani , Cai Chang , Xie Xihe , Lerner Hannah , Mizuiri Danielle , Miller Bruce , Rankin Katherine , Vossel Keith , Cheung Steven , Nagarajan Srikantan , Raj Ashish 
Published: March 2023

Abstract
Alzheimer’s disease (AD) is the most common form of dementia, progressively impairing memory
and cognition. While neuroimaging studies have revealed functional abnormalities in AD, how these
relate to aberrant neuronal circuit mechanisms remains unclear. We employed a spectral graph-theory
model (SGM) to identify abnormal biophysical markers of neuronal activity in AD. SGM is an analytic
model that describes how long-range fiber projections in the brain mediate excitatory and inhibitory
activity of local neuronal subpopulations. We estimated SGM parameters that captured the regional power
spectra obtained from magnetoencephalography imaging of a well-characterized population of patients
with AD and controls. The long-range excitatory time constant was the most important feature for the
accurate classification of AD and controls and was associated with global cognitive deficits in AD. These
results indicate that a global impairment in the long-range excitatory neurons might be a sufficient factor
underlying spatiotemporal alterations of neuronal activity in AD.
A novel evaluation system of green development performance in the Three Gorges Reservoir Area and its spatial-temporal pattern
Authors: Chen Ying , Liao Ying , Wen Chuanhao 
Published: March 2023

Abstract
The Three Gorges Project, a world-class water conservancy project, was built in 2020 and set a new world record in annual electricity generation. It is undeniable that it has brought considerable ecological benefits together with economic and social benefits to the Three Gorges Reservoir Area (TGRA). It is full of practical significance to evaluate the green development performance level (GDPL) in the TGRA, which is a new indicator reflecting the comprehensive performance of the Three Gorges Project. This study focuses on evaluating the GDPL in the TGRA. First, we established a novel evaluation system for GDPL in the TGRA, and then the GDPL of 26 regions in the TGRA from 2000 to 2020 were calculated by using overall entropy method and expert scoring method to analyze the development performance of environmental system, economic system and social system and their coupling coordination degree. Also, the temporal and spatial evolution process, regional disparity, and spatial correlation of GDPL in the TGRA were examined through exploratory spatial data analysis (ESDA). The results show that: (1) the GDPL in the TGRA is in a medium level with a score of 0.3–0.4 and is growing stably. Ecological protection and development quality contribute greatly to the GDPL and the inter-regional differences between the head, the belly and the tail sections are narrowing. (2) The coupling degree between the environmental system, economic system and social system in the TGRA is as high as above 0.8, but the coupling coordination degree is only about 0.3. (3) The GDPL in TGRA varies with the region and is at a high level in the belly section, a medium level in the head and tail sections. The six regions in the belly section and one in the tail section, which are of a high level of GDPL, form a shape of the Big Dipper. (4) The global spatial correlation was not obvious in most years except the year of 2000, 2017, 2018 and 2019. The Lisa cluster map shows clusters only emerge in the head and the tail sections, the belly section, in which the GDPL is high, doesn’t show spatial agglomeration. These findings can not only provide references for promoting green development in the TGRA, but also enrich the study of the evaluation of GDPL.
Emergent topological quantum orbits in the charge density wave phase of kagome metal CsV3Sb5
Authors: Yan Binghai , Tan Hengxin , Li Yongkang , Liu Yizhou , Kaplan Daniel , Wang Ziqiang 
Published: March 2023

Abstract
The recently discovered kagome materials AV3Sb5 (A = K, Rb, Cs) attract intense research interest in intertwined topology, superconductivity, and charge density waves (CDW). Although the in-plane 2×2 CDW is well studied, its out-of-plane structural correlation with the Fermi surface properties is less understood. In this work, we advance the theoretical description of quantum oscillations and investigate the Fermi surface properties in the three-dimensional CDW phase of CsV3Sb5. We derived Fermi-energy-resolved and layer-resolved quantum orbits that agree quantitatively with recent experiments in the fundamental frequency, cyclotron mass, and topology. We reveal a complex Dirac nodal network that would lead to a π Berry phase of a quantum orbit in the spinless case. However, the phase shift of topological quantum orbits is contributed by the orbital moment and Zeeman effect besides the Berry phase in the presence of spin-orbital coupling (SOC). Therefore, we can observe topological quantum orbits with a π phase shift in otherwise trivial orbits without SOC, contrary to common perception. Our work reveals the rich topological nature of kagome materials and paves a path to resolve different topological origins of quantum orbits.
Construction of university English teaching connection model based on multimedia fusion
Authors: luo liang 
Published: March 2023

Abstract
In order to improve the cohesion and quality of college English teaching, the cohesion model of college English teaching under the interactive network environment of database server is constructed. This paper puts forward a connecting platform for college English teaching under the interactive network environment of database server based on multimedia fusion. Build a big data analysis model of college English teaching convergence multimedia information in the database server interactive network environment, get the feature quantity of college English teaching convergence information in the queue resource quota manager, and combine the big data mining method to carry out multimedia information fusion and feature clustering processing of college English teaching convergence in the database server interactive network environment. The heterogeneous directed graph fusion clustering is adopted to design the optimal storage structure of college English teaching convergence multimedia information in the database server interactive network environment, and the semantic ontology features of college English teaching convergence multimedia information in the database server interactive network environment are extracted. Through feature optimization retrieval, the design of college English teaching convergence platform and multimedia information fusion in the database server interactive network environment are realized. Through the method of multimedia information fusion of college English teaching convergence under the interactive network environment of database server, differential scheduling is carried out to improve the ability of college English teaching convergence and multimedia information fusion under the interactive network environment of database server. The simulation results show that the designed college English teaching interface platform has high information fusion degree and strong resource allocation ability under the interactive network environment of database server.
Sohlh2 promotes pulmonary fibrosis via repression of p62/Keap1/Nrf2 mediated anti-oxidative signaling pathway
Authors: Liu lanlan , Zhang Xiaoli , Zhang Ruihong , Wang Liyan , Zhi Sujuan , Feng Xiaoning , Liu Xuyue , Shen Ying , Hao Jing 
Published: March 2023

Abstract
Disturbance in the redox balance of alveolar epithelial cells (AECs) was considered as a causal factor for pulmonary fibrosis. The regulatory mechanisms of redox hemostasis in the development of pulmonary fibrosis remain largely unknown. Using a type II AEC-specific Sohlh2 conditional knock-in (CKI) mouse model, we found that Sohlh2, a basic HLH transcription factor, accelerated age-related pulmonary fibrosis. High-fat diet (HFD) resulted in a tremendous increase in lung inflammation and fibrotic changes in the lung tissues of Sohlh2 CKI mice. Sohlh2 overexpression led to a significant rise of intracellular ROS and apoptosis in the lung, mouse primary AECIIs, and human A549 cells, which was attenuated by ROS inhibitor (NAC). Sohlh2 enhanced oxidative stress via repressing p62/Keap1/Nrf2 mediated anti-oxidative signaling pathway. p62, a direct target of Sohlh2, mediated Sohlh2 effects on ROS generation and apoptosis in A549 cells. Hence, our findings elucidate a pivotal mechanism underlying oxidative stress-induced pulmonary fibrosis, providing a framework for aging-related disorder interventions.
DDQ-mediated direct cross-dehydrogenative-coupling (CDC) reaction of thiols with isochroman: A serendipitous metal-free route to C-S bond formation
Authors: Rezaei Soraya , Alizadeh Abdolhamid , Abdi Gisya 
Published: March 2023

Abstract
A direct and efficient carbon-sulfur bond formation method was developed. For the first time, cross-dehydrogenative-coupling (CDC) reaction of an especial type of benzyl ethers (isochroman) and a variety of thiols was investigated. 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) without using any metal catalyst provides a simple and efficient method to construct C-S bond leading to the library of sulfur-containing hetrocyclic compounds. Indeed, we can directly functionalize Csp3-H bond by S-H bond without requiring pre-activation. As a result, this method will increase synthetic efficiency at the most fundamental level of organic synthesis.
Impact of ethylene diamine tetraacetic acid on physiochemical parameters and yield attribute in two varieties of Brassica juncea under lead stress
Authors: Naaz Gul , ALAM NAUSHAD , Kumar Amit 
Published: March 2023

Abstract
Lead is one of the most toxic elements on earth. The harmful effects of lead at higher concentrations were seen on plant vegetation because plants are directly exposed to toxic levels. A previous work with B. juncea varieties were already screened against Pb to assess their endurance capacity from which B. juncea P. Vijay was opted out as the most tolerant, and B. juncea PM 25 was selected as the sensitive cultivar. Indian mustard, a well-known hyperaccumulator plant, is the most promising environmental crop used in diverse situations for ecological clean-up, and a chelating agent, EDTA, having remarkable efficacy, was used in the experiment. In the present study, the pot experiment was conducted in soil pretreated with 1000 mgkg− 1 Pb soil, and pots were augmented with different EDTA (2–10 mmol) concentrations. All the growth parameters were reduced more drastically in plants treated with Pb, however, a non-significant reduction was observed in 5 mmol EDTA treatments. Photosynthetic pigments, yield, nitrate reductase activity, NPK content were affected negatively, in contrast superoxide dismutase, catalase activity, and the ratio of chl a and chlb were increased in Pb and Pb + EDTA treated both varieties. All the parameters of PM 25 variety were affected more than P. Vijay during the experiment. Pb accumulation was elevated significantly by the augmentation of up to 5mmol EDTA in both cultivars. Accumulation of Pb in the shoot was higher in PM 25 than in P. Vijay, whereas root Pb accumulation shows the opposite, i.e., more Pb in roots of P. Vijay than PM 25. However, P. Vijay was found to be more effective in terms of Pb accumulation per plant than PM 25. Hence in the present work, we found that augmentation of Pb-polluted soil with EDTA works well while dealing with B. juncea assisted phytoremediation, and P. Vijay were found to be stronger candidate than PM 25. Also, we found that 5 mmol of EDTA was optimum for phytoremediation of the soil polluted with up to 1000 mg Pb kg− 1 soil.
Spatial analysis of groundwater potential using remote sensing and GIS-based multi-criteria decision analysis method in Fetam-Yisir catchment, Blue Nile Basin, Ethiopia
Authors: Gizaw Endalkachew Abebaw , Bawoke Getnet Taye , Alemu Melkamu Meseret , Anteneh Zelalem Leyew 
Published: March 2023

Abstract

Detecting the potential region of the groundwater resource is a difficult issue all over the world. Know a day, advanced geospatial technologies are excellent tools for efficient planning, managing, and assessing groundwater resources, particularly in data-scarce developing nations. Remote sensing (RS) and GIS-based multi-criteria decision analysis (MCDA) methods were applied to delineate the groundwater potential (GWP) in the Fetam-Yisir catchment, Blue Nile Basin, Ethiopia. Nine thematic layers: slope, geomorphology, normalized difference vegetation index (NDVI), topographic elevation, geology, land use/land cover (LULC), soil, rainfall, and drainage density from satellite and conventional data were used. The analytical hierarchy process (AHP) of an MCDA was employed to compute the corresponding normalized weight for the class in a layer and weights for the thematic layers on the base of their relative significance to the GWP. Integration of all thematic maps has been done using the ‘‘Weighted overlay’’ tool to obtain a GWP map. The GWP map is then validated using observed boreholes, and springs yield data. The verification of the final GWP zone map against yield data confirms 81.82% agreement indicating the authenticity of the method. The final GWP output confirmed that 43.2% area of the Fetam-Yisir catchment falls in a ‘‘good’’ GWP zone; 41.8%, 7.44%, 7.4%, and 0.02% of the area falls in ‘‘moderate’’, ‘‘Very good’’, “Poor” and ‘‘very poor’’ GWP zones, respectively. The sensitivity analysis divulges that the GWP map is highly sensitive to slope with a mean variation index of 1.45%. Thus, this study can be used for effective groundwater exploration, development, and sustainable abstraction, as well as it guides the researchers in locating the GWP zone.
Collecting duct carcinoma with retroperitoneal mass as initial presentation: A rare case report
Authors: Ye Rupei , Liao Yehui , Xia Tian , Zhang Xinfeng , Lu Qiyi , Xiao Xiuli 
Published: March 2023

Abstract
Background: Collecting duct carcinoma (CDC) is a rare renal tumor, originating from the distal collecting duct. CDC rarely presents as a primary tumor outside the renal system.
Case presentation: In this study, we report a rare case of collecting duct carcinoma, with an initial presentation of retroperitoneal lymph node metastasis, and no identifiable primary renal tumor on CT, at the time of diagnosis. The patient was a 64-year-old man presenting with lower back pain. Preoperative CT showed a round, soft tissue mass, measuring 6.7×4.4×3.3 cm, in the left retroperitoneum with no exact occupying lesion in the left kidney. Clinically, ectopic pheochromocytoma was considered to be a differential diagnosis, and tumor resection was performed. Postoperative pathological results demonstrated that the mass was a fused lymph node, and the tumor cells were destroying the structure. The final diagnosis was lymph node metastatic collecting duct carcinoma, by histology and immunohistochemistry. No further treatment was performed as no space occupying lesion was found in the kidney. Three months later, CT was reexamined, and a mass of 3.6 cm in diameter, was found in the lower left kidney, along with multiple soft tissue masses, in the left renal hilum. Considering recurrence or metastasis, the patient was recommended to undergo surgical treatment, but the patient refused. Four months later, CT was re-examined. The tumor had rapidly progressed but the patient refused treatment again. As per the author's press release (eleven months after the first discovery), the patient is still alive.
Conclusion: CDC is a rare malignant renal carcinoma, with a high chance of rapid progress, regional lymph nodes involvement and metastasis. It presents diagnostic challenges to clinicians and pathologists, particularly, in the absence of radiographically detectable intrarenal lesions. Definite diagnosis is based on pathological examination combined with immunohistochemical staining.
Effect of in situ simulation training for emergency caesarean section on maternal and infant outcomes
Authors: Wang Yin , Liu Dehong , Wu Xiumei , Zheng Chenmin , Chen Xianxia 
Published: March 2023

Abstract
Background
Emergency caesarean section (ECS) is an effective method for rapid termination of pregnancy and for saving maternal and foetal life in emergencies. Experts recommend that the interval from decision of operation to the decision to delivery interval (DDI)should be shortened as much as possible. Studies have shown that improving communication skills among staff by performing simulation drills shortens DDI, thus reducing the occurrence of adverse obstetric events and protecting maternal and child safety. In situ simulation (ISS) training is a simulation-based training approach for clinical team members conducted in a real-world clinical setting. In August 2020, Anhui Maternal and Child Health Hospital began ISS training on the rapid obstetric response team (RRT) in our hospital area for emergency caesarean section. This study aimed to investigate the effect of implementing in situ simulation training for emergency caesarean section on maternal and child outcomes by comparing maternal and child-related data on emergency caesarean section in two hospital areas.
Methods
Data on cases of emergency caesarean delivery implemented in two hospital districts from August 2020 to August 2022 were collected: 19 in the untrained group and 26 in the training group. The two groups were compared concerning the interval from the decision of operation to the decision to delivery interval (DDI), the interval from the decision of operation to the initiation of skin removal, the interval from skin removal to the decision to delivery interval, and the neonatal situation.
Results
The interval between the start of DDI and the decision to cut skin was significantly shorter in the training group than in the untrained group (P < 0.01), the interval between cutting skin and feticide was not significantly different between the two groups (P > 0.05), and the Apgar score at 1 minute after birth was higher in the training group than in the untrained group (P < 0.05).
Conclusions
The DDI for emergency caesarean section procedures can be significantly shortened, and neonatal Apgar scores improved by implementing in situ simulation training for emergency caesarean section in obstetric rapid response teams. In situ simulation training is an effective tool for training in emergency caesarean section procedures and is worth promoting.
Regional Economic Analysis of Major Areas in South Korea:
Using a 2005-2010-2015 Multi-Regional Input–Output table
Authors: Lee Seongha , Ishiro Taku 
Published: March 2023

Abstract
South Korea’s Seoul metropolitan area accounts for more than half of the country’s GDP and population. This phenomenon is getting worse annually. Regions outside the metropolitan area of Korea are not only decreasing in terms of economic size, but also becoming more dependent on the metropolitan area in terms of economic structure. In the past, the metropolitan area was based on the service industry and the size of the manufacturing industry was large in other regions, but the size of the manufacturing industry in the metropolitan area also increased over time. To analyze dependence on the Seoul Metropolitan area, this study conducts inter-regional production inducement effects, regional division of labor, and three regional structural decomposition analysis using Korea's 2005-2010-2015 MRIO to further analyze dependence on the metropolitan area. Furthermore, this research integrates industry classification and realizes price level of Input-Output tables to link three years MRIO in three industries: Wholesale and retail trade and product brokerage services, Motor vehicle, and Semiconductor and other electronic components. From the inter-regional production inducement effect, the effect between the metropolitan area and each region is calculated through the regional export and import effects of each region. Furthermore, the proportion of metropolitan areas in major industries and their changes are measured through regional division of labor, and through multi regional structural decomposition analysis, the growth factors of each region over the 10 years are determined by own region, metropolitan area, and other regions.