bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of pharmacist-initiated perioperative multidisciplinary pharmaceutical care model and clinical pathway on pain management in patients undergoing orthopedic surgery: a before-after study
Authors: Wang Ruolun , Liu Benyue , Feng Xia , Tang Bo , Chen Binwei , He Yuhong , Lu Junxiong 
Published: February 2023

Abstract
Background
Poor pain control is common in perioperative orthopedic surgeries. However, there is a lack of exploration of the clinical pharmacy practice model for this population.
Aim
To construct a perioperative pharmaceutical care model and clinical pathway for patients undergoing orthopedic surgeries and evaluate their impact on pain management.
Method
This historical before-and-after study was conducted in the Department of Orthopedics of a tertiary hospital in Guangdong Province, China. The control group was surgical patients who received routine diagnosis and treatment. The intervention group received pain management from a multidisciplinary team based on a pharmacist-initiated pharmaceutical care practice model and clinical pathways for medication management. The primary outcome measures were postoperative pain at rest (PAR) and movement-evoked pain (MEP) scores, number of breakthrough pains, and length of hospital stay.
Results
A total of 320 orthopedic surgery patients were included in the study. Among patients with expected moderate or severe postoperative pain (82.5%), significantly lower PAR and MEP scores were observed in the intervention group 24 hours after the operation compared to the control group (P<0.05). Compared to the control group, hospital stay in the intervention group was shortened by 2.3 days (P<0.001). However, there were no significant differences in the control of breakthrough pain and the incidence of adverse drug reactions (P>0.05).
Conclusion
Pharmacist-initiated multidisciplinary perioperative pain management practice models and clinical pathways could improve outcome indicators related to pain management and realize the role and value of pharmacists.
Metals in the Réunion harrier - tissue concentrations and meaning for conservation
Authors: Hadjadji Cloé , Augiron Steve , Crini Nadia , Amiot Caroline , Driget Vincent , Tourmetz Julie , Renault Samantha , Coeurdassier Michael 
Published: February 2023

Abstract
The Réunion harriers is an endemic raptor on Réunion Island. Several threats endanger its population, poisoning by rodenticides being considered as the main one currently. No information is available on its exposure to other chemicals notably trace metal elements such as lead (Pb), mercury (Hg), and cadmium (Cd). The Réunion harrier is still victim of poaching nowadays. When shooting is not lethal, animals may carry embedded shot in their body and thus be exposed to toxic level of Pb as demonstrated for other raptors. Moreover, recent monitoring suggests a decrease of its breeding success over time. It is known that Hg and Cd could impair reproduction and disturb embryo development in birds. The aim is to measure metal concentrations in the tissues of 30 carcasses of harrier collected from 2016 to 2021. Lead was analysed in liver and humerus while Hg and Cd were measured in livers. Concentrations were compared to toxicological reference values. Overall, the Reunion harrier was not exposed to toxic levels of Pb or Cd. For Hg, 53% of the individuals have residues higher than the threshold compatible with oxidative stress, 13% having liver concentrations above those compatible with reproduction impairment. A positive correlation was found between the proportion of urban area within 55 km² around a harrier and Hg concentration in liver. We conclude that Hg exposure could be a threat for the Réunion harrier population and recommend monitoring the exposure of the most sensitive stages, i.e., embryos and nestlings, to this metal with non-invasive methods.
GS and GPAs relieve radiation-induced apoptosis and pyroptosis in intestinal epithelial cell via Caspase3/GSDME pathway
Authors: Shi Kai , Chen Fei , Li Xiang , Liang Chen , Wei Liang 
Published: February 2023

Abstract
Exposure to ionizing radiation(IR) such as abdominal and pelvic radiotherapy can result in severe intestinal injury, which is alleviated by Ginsenosides(GS) and Ginsenophenolic acids(GPAs). After treatment of IEC6 cells with IR, the growth of the cells was inhibited and the cleavage of Caspase 3 was induced, which was accompanied by the cleavage of Gasdermin E (GSDME), leading to cell apoptosis and pyroptosis. In addition, after adding caspase-3 inhibitor, the indexes of apoptosis and pyroptosis were decreased, indicating that caspase 3-dependent cleavage of GSDME promotes the apoptosis and pyroptosis of IEC6 cells. The IEC6 cells were treated with GS,GPAs and GPS before IR, and the results showed that GS and GPAs could repair the apoptosis and pyroptosis , and alleviate the increase of ROS caused by IR. Moreover, the addition of GS or GPAs can promote cell proliferation. These results suggest that IR induces apoptosis and GSDME-dependent pyroptosis through Caspase 3 activation, which can be relieved by GS and GPAs, thus supporting the potential of GS and GPAs as prevention and treatment of IR-induced intestinal injury.
Elderly and their companion animals, cause for pleasure or for harm, a case report of a non- bite Pasteurella multocida bacteremia in an 85 year old woman
Authors: Ali Evien , Tytgat Niek , Vergote Lieven , Devue Katleen , Nonneman Bart 
Published: February 2023

Abstract
We present a case of an elderly woman suffering from Pasteurella multocida (P. multocida) bacteremia, without obvious bite marks, but owning a pet dog. Although the patient was not immunocompromised, and prompt treatment with antibiotics was initiated, she developed severe septic shock with multiple organ failure and died. In healthy individuals, an infection caused by this bacteria is easy to treat and often harmless, whereas in elderly serious complications can occur. To our knowledge, this is the first report of a fatal outcome of a P. multocida bacteremia in a non-immunocompromised, yet elderly patient. Given the growing cohort of elderly pet-owners seeking medical care, a heightened awareness of zoonosis and its potential fatal outcome is warranted.
A plant peroxisome lipase, SSD5, is required for steryl ester accumulation and activation of autoimmunity
Authors: Xie Wenjun , Li Xuan , Feng Deshun , Buffel Mélanie , Guan Suhua , Liao Wenlin , Smigielski Lara , Li Zizhang , Lenk Andrea , Yao Nan , Pedersen Carsten , Thordal-Christensen Hans 
Published: February 2023

Abstract

Excess cellular sterol is harmful in mammals and plants, but the mechanisms why are awaiting clarification. Here we find a strong autoimmune response to be associated to excess endoplasmic reticulum (ER) sterols. This was obtained by studying a plant peroxisome lipase, SSD5, required for the lesion phenotype of the Arabidopsis syntaxin mutant, pen1 syp122. SSD5 is a lipase with a catalytic triad including a GxSxG motif localized to a subdomain of the peroxisome periphery. Lipidomics revealed reduced steryl ester levels in pen1 syp122 when SSD5 is mutated. This involvement in sterol homeostasis was confirmed by a requirement of SSD5 for the lesions of hise1 psat1 that suffers from excess ER sterol. These data suggest SSD5 is contributing to a peroxisome-located segment of the sterol biosynthesis pathway. SSD5’s contribution to the pen1 syp122 autoimmunity is not associated with nine highly diverse down-stream immune components, and SSD5 does not influence general plant disease levels and immunity. Therefore, our data indicated SSD5 as well as ER sterol functions up-stream of immune activation. This in turn suggests plant excess ER sterol to activate one or more immune receptors.
Intra- and peritumoral MRI radiomics assisted in predicting radiochemotherapy response in metastatic cervical lymph nodes of nasopharyngeal cancer
Authors: Xu Hao , Wang Ai , Zhang Chi , Ren Jing , Liu Jieke , Zhou Peng 
Published: February 2023

Abstract
Background: In this investigation, intratumoral (Intra) and peritumoral (Peri) features obtained from MRI imaging were used to create and evaluate radiomic models for response prediction to radiochemotherapy of metastatic cervical lymph nodes in individuals with nasopharyngeal cancer (NPC).
Methods: Retrospectively, we included 145 consecutive subjects with NPC, 102 in the training set and 43 in the validation set. A total of 5408 initial radiomic features were acquired from the metastatic cervical lymph node's Intra and Peri areas. Then, employing multivariate logistic regression analysis, the radiomic features were chosen and integrated with clinical characteristics to create predictive models. And at last, these developed prediction models were examined using sensitivity, specificity, accuracy, and the area under the curve (AUC) of receiver operating characteristics.
Results: In the training and validation sets, there was no statistically significant variation in the AUC among the Intra radiomic signature, Peri radiomic signature, combined Intra and Peri radiomic signature, and combined Intra and Peri radiomic nomogram (all P > 0.05). With an AUC of 0.941 (0.877-0.978) in the training set and 0.783 (0.631-0.894) in the validation set, the combined Intra and Peri radiomic nomogram enabled good discrimination among the responders and non-responders groups.
Conclusions: The early response of metastatic cervical lymph nodes to radiochemotherapy in individuals with NPC may be predicted by pretreatment radiomic models determined by the combined Intra and Peri features from MRI imaging, facilitating therapeutic interventions and clinical decision-making.
A Modified ICH Scoring Model to Predict Functional Outcomes in Primary Intracerebral Hemorrhage Survivors-Prospective Study
Authors: Tseng Wen-Che , Chiu Yi-Hsiang , Hsiao Ming-Yen 
Published: February 2023

Abstract
Background
Primary intracerebral hemorrhage (ICH) accounts for 85% of ICH and is associated with high morbidity and mortality. Researchers have developed several predictive models for mortality and functional outcomes for ICH since 2001. However, models that predict long-term functional outcomes of activities of daily living (ADL) among ICH survivors remain scarce. This study developed a modified ICH scoring system that incorporates body temperature to predict ADL functional outcomes 1 year after ICH and compared it with the original model.
Methods
This prospective observational study examined the functional outcomes for patients who received rehabilitation 1 year after primary ICH in a tertiary medical center between 2019 and 2021. This study excluded patients who died before discharge and those with ICH related to aneurysm, arteriovenous malformation, or trauma. Body temperature and comorbidities were incorporated into the original ICH score. Functional outcome was based on the modified Rankin Scale (mRS) score and the Barthel Index (BI). Severe dependency in ADL was defined by a BI of ≤60, and severe disability was defined by an mRS score of ≥4 at 1 year after ICH.
Results
A total of 100 patients were recruited. The modified ICH score was significantly associated with functional independence 1 year post-ICH, as measured by both the BI and mRS (p = 0.012 and 0.01, respectively). When predicting severe dependency at the 1 year follow-up, the modified ICH score had a higher area under the receiver operating characteristic curve (AUC) compared with the original ICH score, both in terms of BI (AUC = 0.8545 and 0.8417, respectively) and mRS (AUC = 0.8768 and 0.8466, respectively).
Conclusions
The present study developed a modified ICH score model that outperformed the original model in the prediction of ADL functional outcomes at 1 year. This is the first study to incorporate the effect of long-term rehabilitation into the development of the model.
Risk factors for the leakage of the repair of duodenal wounds. A secondary analysis of the Panamerican Trauma Society multicenter retrospective review.
Authors: Garcia Alberto F , Sanchez Alvaro I , Ferrada Paula , Wolfe Luke , Duchesne Juan , Fraga Gustavo , Benjamin Elizabeth , Campbell Andre , Morales Carlos , Pereira Bruno , Ribeiro Marcelo , Quiodettis Martha , Peck Gregory , Salamea Juan C , Kruger Vitor , Ivatury Rao , Scalea Thomas 
Published: February 2023

Abstract
Background: Leak of the repair of a traumatic duodenal perforation (TDP) determines intra-abdominal infection, fistula, and mortality. The risk factors for the leak of a TDP have yet to be entirely studied. We performed a secondary analysis of a retrospectively collected database conformed from eleven trauma centers from the Americas to identify risk factors for filtration of a TDP.
Methods: Patients ≥18 years old with duodenal trauma, surgically treated from 2006 to 2017, were included. Subjects who died during the first 48 hours were excluded. Demographics, trauma mechanism, trauma severity, associated injuries, transfusions, and type of surgical treatment were examined as potential risk factors for a leak of the surgical repair of the TDP. Multiple logistic regression (MLR) modeling was used to identify independent contributors to the risk of leak.
Results: We included 288 patients. Median age was 29 years (IQR 22-43), and 236(81.9%) subjects were males. Penetrating trauma occurred in 223 (77.3%) patients. Duodenal injury AAST severity was grade 3 in 180 (62.5%) cases and grade 4-5 in 40 (13.9%) patients. Duodenal leakage developed in 50 (17.4%) subjects. Compared with the subjects without a leak, the patients who leaked had significantly lower SBP at admission, higher ISS, higher abdominal AIS, and a higher proportion of duodenal AAST 3 lesions. MLR identified as independent predictors of leakage of the duodenal repair hypotension on admission, abdominal AIS, duodenal AAST grade 3, and duodenal repair with techniques different from primary repair. The discriminative ability (AUC= 0.824 (0.766-0.883) and goodness to fit of the model (p = 0.271) were good.
Conclusion: Hypotension at arrival, abdominal AIS, duodenal OIS=3, and complex surgical procedures were identified as independent risk factors for duodenal repair leakage. We recommend abandoning complex surgical procedures, including duodenal tube decompression, favoring primary duodenal repair.
Objective Wearable Measures Correlate with Self-Reported Chronic Pain Levels in People with Spinal Cord Stimulation Systems
Authors: Patterson Denis , Wilson Derron , Fishman Michael , Moore Gregory , Skaribas Ioannis , Heros Robert , Dehghan Soroush , Ross Erika , Kyani Anahita 
Published: February 2023

Abstract
Spinal Cord Stimulation (SCS) is a well-established therapy for treating chronic pain. However, treatment response to SCS therapy may vary among people with chronic pain due to diverse pain perspectives amongst them. While, currently, chronic pain is evaluated by clinically validated patient reported outcomes (PROs) measures completed during a clinical assessment, monitoring improvement of the participant’s progress over time and comparison of PROs across participants remains subjective and challenging. Thus, objective measures to quantify pain are invaluable. This study aims to assess the feasibility of using digital biomarkers collected from wearables during SCS treatment to predict pain and PRO outcomes. Twenty participants with chronic pain were recruited and implanted with SCS. During the six months of the study, activity and physiological metrics were collected and data from 15 participants was used to develop a machine learning pipeline to objectively predict pain and PRO measures. We were able to reach the accuracy of 0.832 ± 0.012 in pain intensity prediction. The feature importance analysis showed that digital biomarker from the smart watch such as heart rate, heart rate variability, step count, and stand time can contribute to modeling different aspects of pain. The results of the study suggest that wearable biomarkers can be used to predict therapy outcomes in people with chronic pain and bring us another step closer towards objective evaluation of chronic pain.
Scalable synthesis of 2D Ti 2 CT x MXene and molybdenum disulfide composites with excellent microwave absorbing performance
Authors: Miao Baoji , Cao Yange , Zhu Qingsong , Nawaz Muhammad Asif , Ordiozola Jose Antonio , Reina Tomas Ramirez , Bai Zhiming , Ren Junna , Wei Fengchun 
Published: February 2023

Abstract
The signal crosstalk and electromagnetic interference (EMI) problems direly need to be resolved in the rapid development of modern microwave communication technology for a better working frequency and transmission power of electronic systems. Where the new absorbing materials such as molybdenum disulfide (MoS2)/titania (TiO2)/Ti2CTx and MoS2/Ti2CTx composites could meet the requirement of “thin, strong, light weight, and wide band” for excellent absorbing performance. In this work, a lighter Ti2CTx material was selected as the matrix, and MoS2 was in-situ grown on Ti2CTx matrix by traditional hydrothermal method and microwave solvothermal method. The fabricated composite exhibited synergic effect of two-dimensional heterostructural interface and double dielectric elements, where the small amount of TiO2 and the certain proportion of TiO2(Ti2CTx oxide) with MoS2 improve the impedance matching to -54.70 dB RLmin and EABmax of 4 GHz. Polyethylene glycol 200 was used as the solvent instead of water to make Ti2CTx less oxidized during the composite process, where the microwave heating would attain fast speed, short time, high efficiency, and uniform product. Since, the MoS2/Ti2CTx composite without oxidizing possessed a wider EAB at a thinner thickness, thus resulting in the excellent microwave absorption performance and confirming the validity and rationality of new microwave absorption materials.
Identifying and evaluating the effectiveness of phasing and timing of the current situation of lighted-intersection with AIMSUN and SYNCHRO simulator software
Authors: HASANVAND SALMAN 
Published: February 2023

Abstract
In recent years, the growth of vehicles and population growth has caused countless problems in most of the world's megalopolis and also has expanded the range of people's travel due to the simultaneous motorization of transportation with economic development, and the structure of urbanization has changed along with the growth of urbanization. The aim of the research is to improvement the traffic condition and phasing of lighted-intersection for improvement of traffic condition quality and sustainable urban transportation. The research method is quantitating, that it has been exploited transportation theory by using internet and library resources and in the practical part has applied modeling and optimization software Synchro toward of transportation making-smart of an urban.
Maintenance and enhancement of forest ecosystem services: a non-industrial private forest owner perspective
Authors: Bergkvist John , Nikoleris Alexandra , Fors Hanna , Jönsson Anna Maria 
Published: February 2023

Abstract
The transition to a fossil-free society in Sweden is expected to cause an increased demand for forest-derived products which may intensify existing conflicts between environmental goals. This study investigated the role of non-industrial private forest owners in sustaining multiple forest values and their prioritizations among forest ecosystem services, management strategies, as well as their views on future needs. The study results were generated through the means of a survey which revealed a consistent high valuation among all respondents of ecosystem services relating to water quality, timber quality, recreation, and biodiversity. A majority of the respondents desired increasing proportions of mixed species and broadleaved stands within the future forest landscape. Certified forest owners who were members of a forest owner association (CMs) were characterized by favoring values relating to forest production, such as high stand growth and high timber quality, with carbon substitution as the preferred means of mitigating climate change. Forest owners lacking both certification and membership in a forest owner association valued the ecosystem services recreation and biodiversity significantly higher, and also preferred retaining more old forest within the landscape. The survey results revealed a higher management activity among CMs, resulting in a more frequent establishment of mixed and broadleaved stands. Forest owners with medium to large scale properties were well-represented within the CM-category. The results indicated that while the CMs are more interested in production than owners of small properties, they are also more likely to have taken adaptive measures favoring risk management and biodiversity.
The Burden of Ocular Morbidities Among Elderly Patients Visiting a District Healthcare Facility in Malawi
Authors: Banda Owen , Mzumara Thokozani , Ogbonna Grace 
Published: February 2023

Abstract
Background: The population of older adults is growing dramatically. Sadly, this populace is highly prone to develop various ocular morbidities, which if left unattended can lead to blindness.
Aim: To determine the distribution of ocular morbidities among older adults at a secondary hospital in Malawi.
Methods: This was a retrospective cross-sectional study conducted at Mzimba North District Hospital in Malawi. We retrieved 314 patient records from the hospital’s ophthalmic outpatient registry from August 2020 to July 2022 using a non-probability census sampling technique. Data entry and analysis were done employing SPSS (v.26).
Results: More females 164 (52.2%) than males 150 (47.8 %) had ocular morbidities. Cataract 108 (34.4%) was the most common ocular morbidity followed by allergic conjunctivitis 104 (33.1%), then pingueculae 44 (14%), and glaucoma 8 (2.5%) Cataract showed a statistically significant difference between males and females (p<0.05). And Glaucoma portrayed a statistically significant variation according to age groups (p<0.05). According to the time of the year, most cases were attended to in March compared to August.
Conclusion: The majority of blinding conditions among the elderly in Malawi are preventable. Thus elderly Malawians above 50 years are encouraged to get a routine eye exam at least once a year.
Expression and prognosis of ICOS and its ligand in Chinese lung adenocarcinoma population
Authors: Zhan Xiao-kai , Liu Xi-kun , Zhang Sen , Chen Hong 
Published: February 2023

Abstract
BACKGROUND: Immunotherapy has become the fastest-adopting treatment paradigm for lung cancer with improved survival. By binding with its ligand (ICOSL), an inducible T-cell co-stimulator (ICOS) could contribute to reversing immunosuppression and improving immune response and thus be a potential target for cancer immunotherapy.
METHODS: We selected 54 formalin-fixed, paraffin-embedded tumor tissues from cases with stage I-III lung adenocarcinoma cancer. Immunohistochemical expression of ICOS and ICOSL were evaluated. The correlation with clinical parameters in Chinese patients was also compared with TCGA results.
RESULTS: The positive rates of ICOS and ICOSL were 68% and 81.5% respectively in lung tumor tissues. Among them, 9 cases had low expression of ICOS and 22 cases had high expression of ICOS; ICOSL expression was low in 20 cases and high in 24 cases. According to the IASLC (8th edition), phase I lesions was detected in 21 cases, phase II lesions in 15 cases and phase III lesions in18 cases. The median survival of all patients was 44.5 months, the median DFS was 32 months. Univariate analysis showed that the factors significantly associated with OS were tumor size, regional lymph nodes involvement, stage, and expression level of ICOS/ICOSL. Multivariate analyses demonstrated that only the stage was a significant predictor of prognosis.
CONCLUSION: Our findings suggest that the expression level of both ICOS and ICOSL were significantly associated with prognosis. Therefore, ICOS and its ligand may be potential therapeutic targets in NSCLC.