bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of a national survey of substance use treatment services for youth under community supervision
Authors: Knight Danica K. , Funk Rod R. , Belenko Steven , Dennis Michael , Wiese Amanda L. , Bartkowski John P. , Dembo Richard , Elkington Katherine S. , Flynn Patrick M. , Harris Philip W. , Hogue Aaron , Palinkas Lawrence A. , Robertson Angela A. , Scott Christy K. 
Published: July 2023

Abstract
Background
Despite the heightened risk for substance use (SU) among youth in the juvenile justice system, many do not receive the treatment that they need.

Objectives
The purpose of this study is to examine the extent to which youth under community supervision by juvenile justice agencies receive community-based SU services and the factors associated with access to such services.

Methods
Data are from a nationally representative sample of Community Supervision (CS) agencies and their primary behavioral health (BH) partners. Surveys were completed by 192 CS and 271 BH agencies.

Results
SU services are more often available through BH than CS for all treatment modalities. EBPs are more likely to be used by BH than by CS. Co-location of services occurs most often in communities with fewer treatment options and is associated with higher interagency collaboration. Youth are more likely to receive services in communities with higher EBP use, which mediates the relationship between the availability of SU treatment modalities and the proportion of youth served.

Conclusion
Findings identify opportunities to strengthen community systems and improve linkage to care.
Single nucleotide polymorphisms associated with wine fermentation and adaptation to nitrogen limitation in wild and domesticated yeast strains
Authors: Kessi-Pérez Eduardo I. , Acuña Eric , Bastías Camila , Fundora Leyanis , Villalobos-Cid Manuel , Romero Andrés , Khaiwal Sakshi , De Chiara Matteo , Liti Gianni , Salinas Francisco , Martínez Claudio 
Published: July 2023

AbstractFor more than 20 years, Saccharomyces cerevisiae has served as a model organism for genetic studies and molecular biology, as well as a platform for biotechnology (e.g., wine production). One of the important ecological niches of this yeast that has been extensively studied is wine fermentation, a complex microbiological process in which S. cerevisiae faces various stresses such as limited availability of nitrogen. Nitrogen deficiencies in grape juice impair fermentation rate and yeast biomass production, leading to sluggish or stuck fermentations, resulting in considerable economic losses for the wine industry. In the present work, we took advantage of the “1002 Yeast Genomes Project” population, the most complete catalogue of the genetic variation in the species and a powerful resource for genotype-phenotype correlations, to study the adaptation to nitrogen limitation in wild and domesticated yeast strains in the context of wine fermentation. We found that wild and domesticated yeast strains have different adaptations to nitrogen limitation, corroborating their different evolutionary trajectories. Using a combination of state-of-the-art bioinformatic (GWAS) and molecular biology (CRISPR-Cas9) methodologies, we validated that PNP1, RRT5 and PDR12 are implicated in wine fermentation, where RRT5 and PDR12 are also involved in yeast adaptation to nitrogen limitation. In addition, we validated SNPs in these genes leading to differences in fermentative capacities and adaptation to nitrogen limitation. Altogether, the mapped genetic variants have potential applications for the genetic improvement of industrial yeast strains.
Effects of the level of household access to water, sanitation and hygiene on the nutritional status of children under five, Benin
Authors: Gaffan Nicolas , Kpozehouen Alphonse , Degbey Cyriaque , Ahanhanzo Yolaine Glele , Paraïso Moussiliou Noël 
Published: August 2023

Abstract
Background
Whether or not the Water, Sanitation and Hygiene (WASH) conditions in which children under five live determine their nutritional status is still under discussion. The work aimed to study the effects of household WASH conditions to which children under five are exposed on their nutritional status in Benin.

Methods
The study utilized a cross-sectional design and consisted of secondary analyses using datasets from the fifth Demographic and Health Survey (DHS-V) conducted in Benin. Stunting, wasting and underweight were the dependent variables. The WASH conditions in which children live were evaluated in the immediate environment, i.e., at the level of their households. After describing the study variables, the relationships between the dependent variables and the exposures were checked using multivariate logistic regression. Data analysis was performed with Stata 15 and took into account the survey’s sampling design.

Results
The prevalence of stunting, wasting and underweight was 31.15% (95% CI = 29.90-32.42), 4.79% (95% CI = 4.33–5.31) and 15.82% (95% CI = 14.92–16.76), respectively. The stunting odds were 1.35 (95% CI = 1.15–1.59) and 1.27 (95% CI = 1.01–1.59) times higher for children from households with no water and sanitation services, respectively, compared to children living in households with basic water and sanitation services. Children under five from households with no hygiene facilities and using limited hygiene services had 1.31 (95% CI = 1.05–1.63) and 1.35 (95% CI = 1.10–1.67) times the odds of being stunted, respectively, compared to children covered by basic hygiene facilities. There is no evidence of a significant relationship between household access to WASH and wasting in children under five. The odds of being underweight were 1.33 (95% CI = 1.02–1.72) times higher among children under five from households with limited hygiene facilities than among children from households with basic hygiene facilities.

Conclusion
Interventions to fight malnutrition in children under five should include a WASH dimension.
Players’, Head Coaches', And Medical Personnels' Knowledge, Understandings and Perceptions of Injuries and Injury Prevention in Elite-Level Women’s Football in Ireland
Authors: Horan Dan , Kelly Seamus , Hägglund Martin , Blake Catherine , Roe Mark , Delahunt Eamonn 
Published: July 2023

AbstractBackgroundTo manage injuries effectively, players, head coaches, and medical personnel need to have excellent knowledge, attitudes, and behaviours in relation to the identification of risk factors for injuries, the implementation of injury prevention initiatives, as well as the implementation of effective injury management strategies. Understanding the injury context, whereby specific personal, environmental, and societal factors can influence the implementation of injury prevention initiatives and injury management strategies is critical to player welfare. To date, no qualitative research investigating the context of injuries, has been undertaken in elite-level women’s football. The aim of our study was to explore the knowledge, attitudes, and behaviours of players, head coaches, and medical personnel in the Irish Women’s National League (WNL) to injury prevention and injury management.MethodsWe used qualitative research methods to explore the knowledge, attitudes, and behaviours of players, head coaches, and medical personnel in the Irish WNL to injury prevention and injury management. Semi-structured interviews were undertaken with 17 players, 8 medical personnel, and 7 head coaches in the Irish WNL. The data were analysed using thematic analysis. Our study is located within an interpretivist, constructivist research paradigm.ResultsThe participants had incomplete knowledge of common injuries in elite-level football, and many held beliefs about risk factors for injuries, such as menstrual cycle stage, which lacked evidence to support them. Jumping and landing exercises were commonly used to reduce the risk of injuries but evidence-based injury prevention exercises and programmes such as the Nordic hamstring curl, Copenhagen adduction exercise, and the FIFA 11+ were rarely mentioned. Overall, there was dissatisfaction amongst players with their medical care and strength and conditioning (S & C) support, with resultant inadequate communication between players, head coaches, and medical personnel.ConclusionPoor quality and availability of medical care and S & C support were considered to be a major obstacle in the effective implementation of injury risk reduction strategies and successful return-to-sport practices. More original research is required in elite-level women’s football to explore injury risk factors, injury prevention initiatives, and contextual return-to-sport strategies, so that players, head coaches, and medical personnel can use evidence that is both up-to-date and specific to their environment.
How should multiple myeloma research change in a patient-oriented world? Findings and lessons from the pan-Canadian myeloma priority setting partnership
Authors: Bridges Sarah , Fowler Samantha , McLaughlin Lauren , Robichaud Marc , Ridgway Barbara , Reece Donna , Song Kevin , Dalrymple Lorelei , Sully Robin , Nason Sharon , Rowland Suzanne , MacDonald Trish , Paine William , Gulliver Adrienne , Reiman Anthony 
Published: July 2023

Abstract
Background
Over the last decade there has been considerable research into the treatment, management, and quality of life of people living with multiple myeloma. However, there has been limited investigation into topics deemed important to patients and caregivers within this community. We conducted a James Lind Alliance Priority Setting Partnership to establish the ‘Top 10 Priorities for Myeloma Research’, informed by patient and public partners.

Methods
A research team and steering group were established in 2019 to conduct the myeloma priority setting partnership. Steering group members included patients, caregivers, and healthcare providers who advised the research team and oversaw the scope of the project, grounded on their lived experience. Following the James Lind Alliance guidelines for identification and ranking of research questions, we used surveys and a virtual workshop to collect and prioritize questions posed by myeloma patients, caregivers, and healthcare providers across Canada.

Results
The Top 10 list of priorities for myeloma research was finalized at the consensus-building workshop and encompassed questions related to diagnosis, treatment, management, and living well with myeloma. A final participant evaluation survey elicited a positive response.

Interpretation
The myeloma priority setting partnership identified the research priorities of people living with myeloma, caregivers, and healthcare providers to inform clinical research on this disease going forward. This project underscores the importance of patient and public engagement in the identification of research questions, highlighting the concerns of people affected by myeloma to ultimately improve the lives of people living with this disease.
The association between 24-hour activity, sedentary and sleep compositions and mental health in Australian adults: a cross-sectional study
Authors: Curtis Rachel G , Dumuid Dot , McCabe Hamish , Singh Ben , Ferguson Ty , Maher Carol 
Published: August 2023

Abstract
Background
Physical activity, sedentary behaviour, and sleep are key components to health and well-being. Compositional data analysis of activity data overcomes the limitations of traditional statistical approaches and comprehensively assesses the association of all activities throughout a 24-hour day. Few studies have used compositional analysis to explore associations between movement behaviours and mental health. This study examined the association between 24-hour activity compositions and mental health in middle-aged Australian adults.

Methods
This study used cross-sectional data from participants (n = 322; mean age 40.4 years; 58.1% female; 47.8% university degree; 84.8% partnered) in the longitudinal Annual Rhythms in Adults’ lifestyle and health study (Adelaide, Australia). Activity composition (sleep, sedentary behaviour, light physical activity, and moderate-to-vigorous physical activity) was derived using 24-hour Fitbit accelerometry from the first month of participation (December). Mental health outcomes (depression, anxiety, and stress) were obtained from the Depression Anxiety Stress Scale 21-item short-form (DASS-21). The associations between activity composition (conveyed as isometric log ratios) and DASS-21 scores were examined using compositional multi-level linear regression models with a random intercept for clustering of individuals within families. Using the compositional time reallocation model, expected differences in mental health were examined for hypothetical time reallocations between individual activities.

Results
Favourable associations were observed when time (15 min) was reallocated to light physical activity from sleep (depression: -0.31 [95% CI=-0.57: -0.06]; anxiety: -0.20 [95% CI=-0.37: -0.03] and from sedentary behaviour (depression: -0.29 [95% CI=-0.46: -0.13]; anxiety: -0.14 [95% CI=-0.25: -0.03]; stress: -0.16 [95% CI=-0.31: -0.01]). Detrimental associations were observed when time was reallocated away from light physical activity to sleep (depression: 0.32 [95% CI = 0.07: 0.58]; anxiety: 0.20 [95% CI = 0.03: 0.37]) and to sedentary behaviour (depression: 0.30 [95% CI = 0.13: 0.48); anxiety: 0.15 [95% CI = 0.03: 0.26]; stress: 0.17 [95% CI = 0.01: 0.32]). There were no associations when time was allocated to or from moderate-to-vigorous physical activity.

Conclusion
The way adults spend their time across a 24-hour day is associated with their mental health. Spending more time in light physical activity appears favourable if this time is taken from sleep and sedentary behaviour. These findings provide support for “move more, sit less” public health messages.

Trial registration
This study was prospectively registered on the Australian New Zealand Clinical Trial Registry (Trial ID: ACTRN12619001430123) on the 16/10/2019.
Association of Gestational Diabetes Mellitus Complicated With Short Sleep Duration and Child Neurodevelopmental Delay
Authors: Zhu Yuanyuan , Wang Haixia , Ma Ruirui , Zhang Lei , Wang Yuhong , Zhang Yu , Shao Ziyu , Zhu Daomin , Zhu Peng 
Published: July 2023

Abstract

Context
Gestational diabetes mellitus (GDM) is a risk factor for child neurodevelopmental delay. Maternal short sleep duration (SSD) may aggravate glucose metabolism disorder in women with GDM. However, it is unclear whether maternal SSD will further affect the neurodevelopmental outcomes of children.

Objective
To identify the association of GDM complicated with SSD and child neurodevelopmental delay.

Methods
This prospective study included 7069 mother-child pairs. Between 24 and 28 weeks of gestation, GDM was based on the 75-g oral-glucose-tolerance test. Self-reported sleep duration was collected via the Pittsburgh Sleep Quality Index questionnaire in the second (24-28 weeks) and third (32-36 weeks) trimesters. Outcomes of neurodevelopmental delay in 6 to 36 months postpartum were evaluated using Denver Developmental Screening Test-II and Gesell Development Diagnosis Scale.

Results
Compared with the unexposed group, women with “GDM + SSD” have the greatest risks of child neurodevelopmental delay (hazard ratio with 95% CI: 1.58 [1.03-2.44]). “GDM + SSD” was associated with the greatest risks of maternal-fetal glucose metabolic disorder. An interquartile ratio (0.58 mmol/L) increase in cord blood C-peptide was associated with the risk of child neurodevelopmental delay (hazard ratio with 95% CI: 1.28 [1.12-1.48]). The stronger linear association of maternal glucose metabolism profiles and C-peptide in women with “GDM + SSD” was also demonstrated. The proportion of association between “GDM + SSD” and child neurodevelopmental delay mediated by C-peptide was 14.4%.

Conclusion
GDM complicated with SSD was associated with increased risk for child neurodevelopmental delay by enhancing the intergenerational association of maternal-fetal glucose metabolism disorder.
Systematic analysis of the Frazzled receptor interactome establishes previously unreported regulators of axon guidance
Authors: Zang Yixin , Bashaw Greg J. 
Published: August 2023

ABSTRACT
The Netrin receptor Dcc and its Drosophila homolog Frazzled play crucial roles in diverse developmental process, including axon guidance. In Drosophila, Fra regulates midline axon guidance through a Netrin-dependent and a Netrin-independent pathway. However, what molecules regulate these distinct signaling pathways remain unclear. To identify Fra-interacting proteins, we performed affinity purification mass spectrometry to establish a neuronal-specific Fra interactome. In addition to known interactors of Fra and Dcc, including Netrin and Robo1, our screen identified 85 candidate proteins, the majority of which are conserved in humans. Many of these proteins are expressed in the ventral nerve cord, and gene ontology, pathway analysis and biochemical validation identified several previously unreported pathways, including the receptor tyrosine phosphatase Lar, subunits of the COP9 signalosome and Rho-5, a regulator of the metalloprotease Tace. Finally, genetic analysis demonstrates that these genes regulate axon guidance and may define as yet unknown signaling mechanisms for Fra and its vertebrate homolog Dcc. Thus, the Fra interactome represents a resource to guide future functional studies.
Gastruloid-derived primordial germ cell-like cells develop dynamically within integrated tissues
Authors: Cooke Christopher B. , Barrington Christopher , Baillie-Benson Peter , Nichols Jennifer , Moris Naomi 
Published: August 2023

ABSTRACT
Primordial germ cells (PGCs) are the early embryonic precursors of gametes – sperm and egg cells. PGC-like cells (PGCLCs) can currently be derived in vitro from pluripotent cells exposed to signalling cocktails and aggregated into large embryonic bodies, but these do not recapitulate the native embryonic environment during PGC formation. Here, we show that mouse gastruloids, a three-dimensional in vitro model of gastrulation, contain a population of gastruloid-derived PGCLCs (Gld-PGCLCs) that resemble early PGCs in vivo. Importantly, the conserved organisation of mouse gastruloids leads to coordinated spatial and temporal localisation of Gld-PGCLCs relative to surrounding somatic cells, even in the absence of specific exogenous PGC-specific signalling or extra-embryonic tissues. In gastruloids, self-organised interactions between cells and tissues, including the endodermal epithelium, enables the specification and subsequent maturation of a pool of Gld-PGCLCs. As such, mouse gastruloids represent a new source of PGCLCs in vitro and, owing to their inherent co-development, serve as a novel model to study the dynamics of PGC development within integrated tissue environments.
Conserved chamber-specific polyploidy maintains heart function in Drosophila
Authors: Chakraborty Archan , Peterson Nora G. , King Juliet S. , Gross Ryan T. , Pla Michelle Mendiola , Thennavan Aatish , Zhou Kevin C. , DeLuca Sophia , Bursac Nenad , Bowles Dawn E. , Wolf Matthew J. , Fox Donald T. 
Published: August 2023

ABSTRACT
Developmentally programmed polyploidy (whole-genome duplication) of cardiomyocytes is common across evolution. Functions of such polyploidy are essentially unknown. Here, in both Drosophila larvae and human organ donors, we reveal distinct polyploidy levels in cardiac organ chambers. In Drosophila, differential growth and cell cycle signal sensitivity leads the heart chamber to reach a higher ploidy/cell size relative to the aorta chamber. Cardiac ploidy-reduced animals exhibit reduced heart chamber size, stroke volume and cardiac output, and acceleration of circulating hemocytes. These Drosophila phenotypes mimic human cardiomyopathies. Our results identify productive and likely conserved roles for polyploidy in cardiac chambers and suggest that precise ploidy levels sculpt many developing tissues. These findings of productive cardiomyocyte polyploidy impact efforts to block developmental polyploidy to improve heart injury recovery.
Development of Photoremovable Protecting Groups Responsive to Near-Infrared Two-Photon Excitation and Their Application to Drug Delivery Research
Authors: Nguyen Linh Tran Bao , Abe Manabu 
Published: August 2023

Abstract
Researchers have been actively pursuing the development of photoremovable protecting groups (PPGs) that respond to near-infrared (NIR) two-photon (2P) excitation and the use of their caged compounds in cellular experiments. Our recent developments are summarized in this Account. This research on 2P excitation reactions will considerably contribute to the elucidation of the mechanism of functional expression of biologically active substances in biological samples and will lead to the development of novel drugs and new disease treatment methods. Other active research areas include imaging of materials that are responsive to 2P excitation and nanomaterial synthesis. We hope that these research fields will be useful for designing molecules sensitive to 2P excitation in the NIR region.
SOWN AREAS AS A FACTOR IN THE FORMATION OF FOOD INDEPENDENCE OF THE JEWISH AUTONOMOUS REGION
Authors: Stelmakh Elena V. , Komarova Tatiana M. , Solovchenkov Sergey A. 
Published: July 2023

The aim of this study is to determine the impact of the ratio of sown areas and own production of agricultural products on the food independence of the Jewish Autonomous Region in 2005-2020.
Material and methods. The authors, in carrying out a comparative analysis of the dynamic series on the indicators of the land area by type of land and indicators of agricultural production, used the economic-statistical method, the method of analysis and synthesis, as well as methods of vertical and horizontal analysis.
Results. The data obtained indicate a decrease in the indicators of agricultural production on the territory of the subject. It is determined that the indicators of agricultural areas remain unchanged. At the same time, in 2020 there is a significant increase in the sown areas from 87.2 thousand hectares to 136.1 thousand hectares. However, when considering the indicators of own production of agricultural products, there is clearly a steady trend, with a general decline in indicators in 2020 compared with 2005, which forms a low level of food independence