bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transferencia de conocimiento desde las universidades a las empresas
Authors: Betancur-Amariles Jorge Henry , Rodríguez-Santana Gastón Darío , Garcés-Bolívar Jhon Fredy 
Published: August 2023

La transferencia de conocimiento (TC) desde las universidades a las empresas se desarrolla de múltiples formas, una de las cuales es la práctica realizada por los estudiantes y orientada por profesores. El objetivo de la investigación es evaluar el impacto de la TC y en la gestión del conocimiento (GC) de las empresas. El problema de Investigación surge en el análisis de las prácticas profesionales como una de las formas de TC de las universidades. La metodología aplica dos componentes: el primero identificó las variables implicadas en cada caso de TC como sectores de las empresas, niveles, departamentos de aplicación, y campos de conocimientos de las empresas; el segundo analiza la gestión del conocimiento en el marco de la teoría de Nonaka & Takeuchi a partir de los tres componentes: las cuatro formas (FM), cinco condiciones (CD) y cinco fases (FS). Los resultados se analizarán con apoyo de software SPSS con el fin de reflejar el impacto de la TC y la manera como se gestiona el conocimiento transferido en las empresas.
El monitoreo de la calidad educativa como pilar para la buena Gestión de Proyectos en futuros profesionales en ingeniería
Authors: Cruz-Zuñiga Nidia 
Published: August 2023

La calidad siempre debería estar presente en la gestión de proyectos en ingeniería, pero para que los futuros profesionales puedan interiorizar el concepto de calidad en todo lo que hacen se requiere que desde su formación el tema haya sido un eje transversal en su proceso de aprendizaje. Los procesos de autoevaluación y acreditación de las carreras buscan asegurar una calidad mínima en la educación profesional de los futuros graduados, y con esto influir en las competencias profesionales que puedan desarrollar. En las últimas décadas las agencias acreditadoras de carreras de ingeniería a nivel mundial han impulsado la necesidad de evaluar los atributos de egreso en las personas que se gradúan de carreras de ingeniería como un paso previo a garantizar las competencias deseadas en la persona profesional, lo que también está directamente relacionado con el aseguramiento de la calidad de la educación superior en estas disciplinas. Enlazar los hallazgos de estos procesos de evaluación con las reformas curriculares resulta un insumo clave para mejorar el desarrollo de las carreras y de los procesos de enseñanza – aprendizaje con el estudiantado, en especial en algunos atributos clave para la buena gestión de proyectos como los son: la comunicación oral y escrita, el trabajo en equipo, la resolución de problemas, entre otros. El presente trabajo expone el caso de la Licenciatura en Ingeniería Civil de la Universidad de Costa Rica, donde se aborda la metodología integral que se aplicó para llevar a cabo una reforma curricular que contemplara la necesidad de evidenciar los atributos de egreso y los retos de la acreditación con miras a la mejora del programa, enlazado en cómo esto se espera que contribuya con las destrezas de las futuras personas ingenieras en la ejecución de proyectos de ingeniería.
The role of inflammatory parameters in the management of cases with atypia of undetermined significance/follicular lesions of undetermined significance
Authors: SÜLEYMAN Marlen , BEZİRCİ Rıfat 
Published: August 2023

AIM: This study aimed to evaluate the potential of hematologic parameters and markers such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) to predict the risk of malignancy in patients whose biopsy results were classified as Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance (AUS/FLUS).
MATERIAL AND METHOD: A total of 188 patients who underwent thyroidectomy at a General Surgery clinic were included in the study. Hematological parameters, including neutrophil count, platelet count, lymphocyte count, monocyte count, and mean platelet volume (MPV) were collected from the hospital database. NLR, PLR, MLR, SII, and SIRI were calculated. Statistical analyses were performed using SPSS v25.
RESULTS: 38 patient (20.21%) were male and 150 patients (79.79 %) were female. The mean age was 48.6 (range 23-79,	standard deviation (SD) ± 12.41years). Histopathological examination of the thyroidectomy specimens revealed benign findings in 102 patients (54.3%) and malignant findings in 86 patients (45.7%). The mean age of the malignant group was 45.6, while that of the benign group was 51.1 (p = 0.02). The median tumor size was 17 mm in the malignant group and 21 mm in the benign group (p =0.042). Mean neutrophil count were 4.29 ± 1.0 × 109/L in the benign group and 4.69 ± 1.9 × 109/L in malignant group, respectively (p = 0.031). NLR values were calculated as 1.89 for the benign group and 1.99 for the malignant group (p = 0.045). SII values were higher in the malignant group, with a median value of 584.11× 109/L in the malignant group, median value were 504.63× 109/L in the benign group (p=0.037).
Multivariate logistic regression analysis revealed that both age (odds ratio (OR) = 0.964; 95% confidence interval (CI)= (0.939 – 0.989); p = 0.05) and neutrophil count (odds ratio (OR) = 1.598; 95% confidence interval (CI)= (1.118 – 2.285); p = 0.01) had a significant impact on the differentiation between benign and malignant thyroid nodules.
CONCLUSION: Age and neutrophil count were identified as independent risk factors for malignant thyroid nodules. Among patients with Bethesda Category III thyroid nodules, those under 59.5 years of age and with a neutrophil count above 4.16 x 10^9/L have an increased risk for thyroid malignancy.
Platelet count, monocyte count, MPV and inflammatory parameters, such as PLR, MLR, and SIRI, were insufficient for detecting malignancy in Bethesda III nodules. In this group, young age, small nodule size, high neutrophil count, NLR, and SII were identified as risk factors for malignancy. The Thyroid Imaging Reporting and Data System (TI-RADS) characteristics of nodules should also be considered in the management of these patients.
Regulatory measures when implementing a new medical device into the cosmetic surgery industry. A case example: Macrolane
Authors: Selvaggi Gennaro , Elander Anna 
Published: August 2023

Over the past two decades, the cosmetic surgery industry has experienced significant global growth. This expansion has piqued the interest of healthcare professionals and product manufacturers, both aiming to enhance accessibility to surgery for a broader demographic.
This manuscript presents the case example of “macrolane” hyaluronic acid. This product was introduced into the cosmetic surgery industry in 2007 and then removed from the market in 2012 by the manufacturer. The manuscript also presents and discusses the regulatory measures that were enacted following the introduction of macrolane into the European market.
Specifically, these regulatory measures involved: insurance, professional qualifications and training, clinician representatives, sanitation, safety, cooling-off periods, informed consent, and advertising. Within the manuscript, it is also highlighted that interests from different stakeholders can create tension in the cosmetic industry, specifically: 1. clients might ask for a product, and they need to be protected; 2. healthcare providers are seeking a profit, and are subject to liability; 3. product’s manufacturers, who are seeking to expand their market, need to pass through regulatory processes.
In conclusion, we wish to raise awareness of the ethical issues related to the regulatory measures implemented by European regulatory agencies responsible for public health, especially during the launch of a new product. These ethical considerations encompass several aspects: establishing accountability for validating research authenticity, delineating the functions of compensatory systems, overseeing educational processes, and supervising advertising and marketing practices. It should be noted that the comprehensive exploration of these ethical matters falls outside the scope of this manuscript, as they pertain more to public affairs rather than the realm of cosmetic surgery itself. Therefore, the discourse on these matters is better suited for engagement by experts in political and social ethics.
Level of Evidence: Level V, analysis of current regulatory practices.
The phenomenon of bat populations as a characteristic of watansoppeng city as a biology learning resource for students on ecosystem materials
Authors: Febriani Mitha , Rompegading Andi Badli , Irfandi Rizal , Arafah Muhammad , Rijal Syamsu , Yani Ahmad , Nur Muhammad , Nasir Muhammad 
Published: August 2023

This research is a case study research using qualitative descriptive research methods. The purpose of this study is to describe the phenomenon of the Bat population in Watansoppeng City and describe the benefits of research results from the Bat population phenomenon in Watansoppeng City to be used as a source for learning Ecosystem Biology. This research was conducted at the Environmental Service of Soppeng Regency and in Botto Village, Lalabata District, Soppeng Regency. The informants of this research were 7 people, namely the Head of the Soppeng Regency Environmental Service, the Secretary of the Soppeng Regency Environmental Service and 5 people from the community. Determination of informants in this study using a purposive sampling technique. Data collection techniques used are observation, interviews and documentation by using two types of data, namely primary data and secondary data. Primary data comes from interviews and direct observations at the research site, while secondary data comes from literature review. The data analysis used is data reduction, data presentation and conclusion drawing/verification. Test the validity of the data used is triangulation. The results obtained are the phenomenon of the Bat population in Soppeng Regency which has existed for a long time due to several factors such as habitat suitability, adequate food sources, protected and preserved so that bats can live and be well preserved. Thus, the phenomenon of the Bat population as a characteristic of the city of Watansoppeng can be used as a source of learning ecosystem material biology.
A Study on Urban Construction Land Use Prediction and Simulation Based on SD-FLUS Model: Taking Changsha City as an Example
Authors: cai Yong , jiao Sheng , wang Zhu , zong WenKe , ou LinZhi 
Published: August 2023

Abstract
The urban construction land use scale is an important aspect of urban research, and simulating the scale and spatial layout of urban development land use is of great significance for sustainable development of urban areas. Currently, traditional methods for predicting urban land use scale lack dynamic research on the relationship between factors that affect urban land use scale, resulting in predictions that deviate from actual situations. In this paper, we combine the advantages of the system dynamics model and the FLUS model to improve traditional methods for predicting urban land use scale. Using Changsha City as a research area, we conducted a prediction of urban land use scale in 2020, and adjusted the model based on multiple years of data. The simulation results were accurate to 0.94 in terms of correlation coefficient (kappa = 0.90). We then applied this model and method to simulate urban land use scale in 2025 in Changsha City, and discussed the feasibility of using this simulation to provide reference for land development and land resource protection.
SARS-CoV and SARS-CoV-2 display limited neuronal infection and lack the ability to transmit within synaptically connected axons in stem cell-derived human neurons
Authors: Luczo Jasmina M. , Edwards Sarah J. , Ardipradja Katie , Suen Willy W. , Au Gough , Marsh Glenn A. , Godde Nathan , Rootes Christina L. , Bingham John , Sundaramoorthy Vinod 
Published: August 2023

Abstract
Sarbecoviruses such as SARS and SARS-CoV-2 have been responsible for two major outbreaks in humans, the latter resulting in a global pandemic. While sarbecoviruses primarily cause an acute respiratory infection, they have been shown to infect the nervous system. However, mechanisms of sarbecovirus neuroinvasion and neuropathogenesis remain unclear. In this study, we examined the infectivity and trans-synaptic transmission potential of the sarbecoviruses SARS and SARS-CoV-2 in human stem cell-derived neural model systems. We demonstrated limited ability of sarbecoviruses to infect and replicate in human stem cell-derived neurons. Furthermore, we demonstrated an inability of sarbecoviruses to transmit between synaptically connected human stem cell-derived neurons. Finally, we determined an absence of SARS-CoV-2 infection in olfactory neurons in experimentally infected ferrets. Collectively, this study indicates that sarbecoviruses exhibit low potential to infect human stem cell-derived neurons, lack an ability to infect ferret olfactory neurons, and lack an inbuilt molecular mechanism to utilise retrograde axonal trafficking and trans-synaptic transmission to spread within the human nervous system.
The content of dissociative hexafluoroisopropanol metabolized from different concentration of sevoflurane and its association with emergence agitation in school-aged children: a systematic, double-blind, randomized study. for their dedication to supporting perioperative childhood research
Authors: Wang Jingting , Jiang Wei , Yang Xiaolin , Lin Jingyan 
Published: August 2023

Abstract

Backgroud Unknown at this time is the mechanism underlying restlessness in recovery period. The risk of emergence agitation (EA) referring sevoflurane (SEV) anaesthesia compared with other ordinary anaesthetic is higher in paediatric practices. The hexafluoroisopropanol (HFIP) concentration has been linked to usage of the SEV. HFIP could play a significant role in the formation of EA. To explore the relationship between free HFIP density gradient and the rate of emergence EA which recorded by the Richmond agitation-sedation scale (RASS) in children from anaesthesia. The primary endpoint were score of RASS in relation to dissociative HIFP concentration, and an analysis of the association between the concentration of HIFP and SEV. The secondary outcomes included the extubation indicates, the postoperative vital signs at different time points, the postoperative complication, as well as the Visual Analogue Scale (VAS). Methods In this single-center, double-blind, randomized study, sixty-six school-age children without liver dysfunction were chosen, divided into three groups, with twenty-two patients in each group. Every group had inhaling SEV at a predetermined concentration. Every three milliliter (ml) of the bloods was taken from every 30 minutes(min) intervals after inhalation and inhalation ceased, and delivered it to the lab for analysis. One-stage headspace equilibration was used to determine the real free HFIP and SEV concentrations in the bloods of patients who had undergone inhalation anesthesia. Results The HIFP concentrations showed a trend of increasing and then decreasing comparing the three groups (P < 0.05) together with a rise in the end-expiratory SEV concentrations. And the concentrations of HIFP peaked in Group N2 at all time points. Group N2 also had the highest RASS score at extubation(P < 0.05). However, the concentrations of free-HIFP increased constantly as the inhalation time increased in three groups, and declined following the end of inhalation. But the Group N3 did so more slowly than the other two groups. Conclusions The incidence of emergence agitation was higher with the moderate concentrations of SEV (1.71%) at three concentrations of SEV inhalation anesthesia which produced the higher concentration of free-HIFP in the pediatric patients. The duration of 1.5 hours of the SEV anesthesia had a tendency to raise the blood levels of free-HFIP, and when the concentrations of SEV inhaled reached a point, the free-HFIP productions in children was repressed.
Psychobehavioral factors and family functioning in mucopolysaccharidosis
Authors: Valle Daniel Almeida , Bara Tiago dos Santos , Furlin Vanessa , Santos Mara Lucia Ferreira , Cordeiro Mara L. 
Published: August 2023

Abstract
Background:
We aimed to evaluate the impact of mucopolysaccharidoses (MPS) on family functioning and related factors.
Methods and Results:
Twenty-five families of MPS patients were included. The communication domain in adaptive behavior exhibited mean scores below the cut-off points in MPS II (35.6±24.3) and III (35.0±22.6). The total difficulty score was associated with the communication domain score in adaptive behavior (p=0.012). Parents of patients with MPS III and VI reported lower (47.1±2.7) and higher (77.4±21.6) quality-of-life scores, respectively; however, there was no significant among-group difference. The quality-of-life scores were positively associated with cultural/intellectual domain (p=0.003) and adaptive behavior (p<0.001) scores. Regarding family functioning, the greatest effects were observed in the areas of independence, intellectual/cultural, activity/recreation, and expressiveness. The domain scores did not differ according to MPS type, treatment, or neurological involvement. The organization domain significantly differed (p=0.015) between families diagnosed for <2 years and >2 years. Family functioning in the cultural-intellectual domain was negatively associated with caregiver stress.
Conclusion:
The impact of MPS on family functioning extends beyond physical aspects and encompasses social and emotional dimensions. By promoting coping strategies, facilitating support networks, and recognizing the positive aspects of caregiving, the overall impact of MPS on families can be mitigated.
Morbidity and Mortality of Patients With Peritoneal Malignancy Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Intraoperative Chemotherapy
Authors: Hotza Greta , Karageorgos Michael , Pastourmatzi Varvara , Baniowda Nader , Kyziridis Dimitrios , Kalakonas Apostolos , Chavouzis Nicolaos , Hotza Irene , Tentes Antonios-Apostolos 
Published: August 2023

Abstract
Background The purpose of this study was to record the incidence, and identify the prognostic variables of morbidity and mortality in patients with peritoneal malignancy undergoing cytoreductive surgery (CRS) combined with hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC).Methods The files of patients with peritoneal malignancy who underwent CRS + HIPEC from 2015–2022 were retrieved. Morbidity and hospital mortality were recorded and correlated to a variety of clinical variables.Results A total of 44/192 (22.9%) patients were recorded with postoperative complications. Grade 3 and 4 complications were 12.5%. The prognostic variables of morbidity were the extent of peritoneal malignancy and the number of suture lines. The mortality rate was 2.5% (5 patients). The number of FFP units, and peritonectomy procedures were identified as prognostic variables of hospital mortality.Conclusions The morbidity rate in patients undergoing CRS + HIPEC is acceptable. The prognostic variables of morbidity are the extent of peritoneal malignancy, and the number of suture lines. The mortality rate is low. The prognostic variables of mortality are the number of FFP units, and the number of peritonectomy procedures.
Safety and efficacy of Low-pressure hyperbaric oxygenation in severe COVID-19 patients: a study protocol of an open-label randomised controlled trial
Authors: Yang Bo , Jiang Zeping , Liu Yuting , Zhou Lan , Ding Lingling , Zhu Lingling , Liu Yang , Liu Nanmei 
Published: August 2023

Abstract

Introduction: COVID-19 pandemic remains an acute global emergency. The situation was especially worrying in mainland China. However, paxlovid shortage led to the underuse of recommended antivirus treatment. Hyperbaric oxygen (HBO) therapy could increase SpO2 in COVID-19 patients with severe hypoxemia. The prior trials suggested this potential effectiveness while the study design and sample size may not be sufficient in illustrating the effectiveness and safety of HBOT. Therefore, we designed the current protocol to examine the hypothesis that HBO may improve disease severity and decrease mortality after infection.
Methods and analysis: This study is an open-label randomised controlled trial. A total of 40 COVID-19 patients with disease progression scale 5 or higher will be randomly assigned to control group or HBO therapy (HBOT) group. The control group will receive usual care according to the latest guidelines of the CDC for COVID-19. Besides the usual care, the patients in HBOT group will receive seven low-pressure (1.6 ATA) HBOT session in consecutive 7 days. The primary outcome was defined as WHO clinical progression scale difference before and after the seven-day study. Secondary outcomes include pulse oximetry value at the end of study; duration of hospitalization; newly developed COVID-related symptoms or comorbidity; serum inflammatory biomarks; chest imagining improvement; and HBOT associated adverse events.
Ethics and dissemination: Ethics approval has been obtained from the Institution Review Board of Naval medical center of PLA (No: 2023010601). Written informed consent will be obtained from each subject. The findings of this study will be actively disseminated through scientific publications and conference presentations.
Trial registration number: ChiCTR2300070759
Analysis of the pregnancy status and outcomes of pregnant women with α-thalassemia: A retrospective clinical study
Authors: Li Yi , Feng Yuanyuan , Zhu Zhiwei , Wei Yiyun , Huang Jing , Chen Hui , Wei Changqiang , Wei Kaiyi , Pang Lihong 
Published: August 2023

Abstract
Background: The prevalence of α-thalassemia is high in Guangxi, and its co-occurrence with pregnancy may impede maternal system functions, with a consequent adverse effect on pregnancy progression and birth outcomes. The study objective was to compare the levels of relevant laboratory parameters, pregnancy complications, and birth outcomes of different types of α-thalassemia in pregnancy and to provide guidance on effective prevention and monitoring of perinatal complications in various types of α-thalassemia in pregnancy and improve associated pregnancy outcomes.
Methods: The observation group comprised 1371 singleton pregnant women with α-thalassemia. The control group comprised 680 non-thalassemia singleton pregnancies during the same period. The thalassemia genotypes of the observation group were tallied and categorized based on their respective genotypes within the group. All relevant clinical data were compared within and between groups.
Results:(1) The ethnic distribution among the α-thalassemia pregnancies was predominantly Han and Zhuang, with the top three genotypes --SEA/ααα, -α3.7/ααα, and αCSα/ααα. (2) The hemoglobin in the experimental group was lower than that in the control group, with the lowest hemoglobin in the intermediate group (P < 0.001), and serum ferritin trending in the opposite direction. The most significant decreases in hemoglobin and ferritin during pregnancy were observed in the intermediate group (P＜0.001). (3) The incidences of abnormal Electrocardiograph, abnormal liver function, hypertensive disorders, Gestational Diabetes Mellitus and thyroid disorders during pregnancy were higher in the observation group than in the control group (P＜0.05). (4) The incidences of preterm labor, caesarean section and postpartum hemorrhage were all higher in the observation group than in the control group (P＜0.05). (5) The delivery weight and neonatal hemoglobin in the observation group were lower than those in the control group (P＜0.05).
Conclusions: Pregnant women with α-thalassemia have the lowest hemoglobin levels, the highest serum ferritin levels, more complications of pregnancy and childbirth than non-thalassemic pregnancies. Pregnancy-related indicators should be monitored and corrected in a timely manner to prevent and reduce adverse pregnancy outcomes with α-thalassemia.