bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Adhesion and the Expression of Adhesion Molecules in PBMCs after Aneurysmal Subarachnoid Hemorrhage: Relation to Cerebral Vasospasm
Authors: Revilla-González Gonzalo , Varela Lourdes María , Ruiz de Azua-López Zaida , Amaya-Villar Rosario , Pezzotti María Rosa , Castro María José , Ureña Juan , González-Montelongo María del Carmen , Castellano Antonio 
Published: February 2023

AbstractAneurysmal subarachnoid hemorrhage (aSAH) is a neurovascular disease produced by extravasation of blood to the subarachnoid space after rupture of the cerebral vessels. After bleeding, the immune response is activated. The role of peripheral blood mononuclear cells (PBMCs) in this response is a current subject of research. We have analysed the changes in PBMCs of patients with aSAH and their interaction with the endothelium, focusing on their adhesion and the expression of adhesion molecules. Using an in vitro adhesion assay, we observed that the adhesion of PBMCs of patients with aSAH is increased. Flow cytometry analysis shows that monocytes increased significantly in patients, especially in those who developed vasospasm (VSP). In aSAH patients, the expression of CD162, CD49d, CD62L and CD11a in T lymphocytes and of CD62L in monocytes increased. However, the expression of CD162, CD43, and CD11a decreased in monocytes. Furthermore, monocytes from patients who developed arteriographic VSP had lower expression of CD62L. In conclusion, our results confirm that after aSAH, monocyte count and adhesion of PBMCs increase, especially in patients with VSP, and that the expression of several adhesion molecules is altered. These observations can help predict VSP and to improve the treatment of this pathology.
Plethysms and operads
Authors: Cebrian Alex 
Published: February 2023

AbstractWe introduce the $${\mathcal {T}}$$
T
-construction, an endofunctor on the category of generalized operads, as a general mechanism by which various notions of plethystic substitution arise from more ordinary notions of substitution. In the special case of one-object unary operads, i.e. monoids, we recover the T-construction of Giraudo. We realize several kinds of plethysm as convolution products arising from the homotopy cardinality of the incidence bialgebra of the bar construction of various operads obtained from the $${\mathcal {T}}$$
T
-construction. The bar constructions are simplicial groupoids, and in the special case of the terminal reduced operad $$\textsf {Sym}$$
Sym
, we recover the simplicial groupoid of Cebrian (Algebraic Geom Topol 21(1):421–446, 2021), a combinatorial model for ordinary plethysm in the sense of Pólya, given in the spirit of Waldhausen S and Quillen Q constructions. In some of the cases of the $${\mathcal {T}}$$
T
-construction, an analogous interpretation is possible.
Flower choice by the stingless bee Tetragonula carbonaria is not influenced by colour-similarity to a higher-reward flower in the same patch
Authors: Forster Caitlyn Y. , Mourmourakis Faelan , Hochuli Dieter F. , White Thomas E. , Latty Tanya , Gloag Rosalyn 
Published: February 2023

AbstractFloral choice by bees is influenced by the bees’ previous experience with flowers. For example, bees may learn to associate particular flower colours with rewards and prefer flowers of that colour in a given patch. In this study, we assessed whether floral choice by the stingless bee Tetragonula carbonaria was influenced by colour similarity to a high-quality neighbour flower, while it contained nectar, and then when it was empty of nectar. We trained T. carbonaria to visit highly rewarding artificial flowers (50% (v/v) honey solution) within a patch that also contained two types of less-rewarding artificial flowers (20% (v/v) honey solution): one of the same colour (though different pattern) as the high-quality flower and one a different colour (and pattern) to the other two flowers. Colonies were tested with blue and yellow colour sets, where either the blue flower was most rewarding and the yellow the least, or vice versa. We then compared preferences between the two equal-quality flowers in the patch under two conditions: (i) when nectar was available from the high-quality flower, and (ii) when the nectar was removed from the high-quality flower. We found that, when available, high-quality flowers were always visited more than low-quality flowers. Under this condition, adjacent lower-quality flowers in the patch received similar levels of visitation, regardless of their colour. When the reward was removed from the high-quality flower (simulating an emptied flower), foragers quickly switched to using the remaining two equal-quality flowers in the patch, but again showed no preference for the similar-coloured flower. Our results indicate that T. carbonaria are adaptable foragers capable of quickly learning and responding to floral reward changes in their foraging environment. At least under our experimental conditions, we found no evidence that T. carbonaria floral choice is influenced by colour similarity to a high-quality resource in the same foraging location.
Revisiting Leonardo on Muscles: Intimations of Mathematical Biology and Biomechanics
Authors: Kemp Martin 
Published: February 2023

AbstractLeonardo da Vinci’s extensive drawings and notes devoted to anatomy do not arise in a medical context. He does not engage with surgery or “physic.” Rather, his aim is to reveal what he understood to be the divine engineering of God’s greatest creation. His earliest anatomical drawings map the conduits for the “spirits” at a deep level not practiced by other artists interested in the human body. The first set of drawings he produced in 1489 describes skulls with brilliant draftsmanship. His notes for these drawings are predominantly concerned with the location of the “common sense” (sensus communis) at the geometrical center of the cranium. The next great set of drawings completed in ca. 1510 expounds the form and functions of the bones and muscles in meticulous mechanical detail, probably in collaboration with the young Paduan doctor, Marcantonio della Torre. Leonardo’s greatest realization of mathematics in anatomy comes when he looks at the valves of the heart; in studying the heart he also conceived a casting technique that he adapted to determine the form of the ventricles in the brain, radically revising the traditional arrangement of these structures. In a range of portrayals from diagrammatic to pictorial and from static to dynamic, Leonardo’s anatomical research is unrivalled in revealing the mechanics of the human body. His work in this context is an underappreciated precursor of the modern science of biomechanics. (Larger-sized versions of the Leonardo drawings presented here are available as supplementary material in the online version of this article.)
The importance of front-of-pack labels in improving health status and eating behavior
Authors: Muzzioli Luca , Mocini Edoardo , Pinto Alessandro 
Published: February 2023

AbstractThe aim of this Editorial is to give an overview on the multiple aspects of front-of-pack labels (FOPLs) and provide the readers a balanced view of the problems raised in this research field, placing them in a wider context. Furthermore, this editorial paper discusses whether and how the use of FOPLs can promote health status in relation to the individual eating pattern and which should be the next research scenarios to investigate to further improve and integrate these tools.
Early life influences on the development of food addiction in college attending young adults
Authors: Wattick Rachel A. , Olfert Melissa D. , Claydon Elizabeth , Hagedorn-Hatfield Rebecca L. , Barr Makenzie L. , Brode Cassie 
Published: February 2023

Abstract
Purpose
There is little investigation into the causes of food addiction. The aim of this study was to determine the impact of early life influences on the development of food addiction in college-attending young adults aged 18–29.

Methods
This study utilized a sequential explanatory mixed-methods research design. College-attending young adults were invited to complete an online survey measuring Adverse Childhood Experiences (ACEs), food addiction, depression, anxiety, stress, and demographic information. Correlations between food addiction and the other variables were analyzed and significant variables were placed into a nominal logistic regression model to predict the development of food addiction. Participants who met the criteria for food addiction were invited to participate in interviews to examine their childhood eating environment and when their symptoms emerged. Interviews were transcribed and thematically analyzed. Quantitative analysis was conducted using JMP Pro Version 16.0 and qualitative analysis was conducted using NVIVO Software Version 12.0.

Results
Survey respondents (n = 1645) had an overall 21.9% prevalence of food addiction. Significant correlations were observed between food addiction and ACEs, depression, anxiety, stress, and sex (p < .01 for all). Depression was the only significant predictor of the development of food addiction (OR = 3.33 95% CI 2.19, 5.05). The most common eating environment described by interview participants (n = 36) was an emphasis on diet culture, ideal body image, and restrictive environments. Symptoms frequently emerged after transitioning into college and having the ability to make their own food choices.

Conclusion
These results show the impact of early life eating environments and young adulthood mental health on the development of food addiction. These findings contribute to the understanding of underlying causes of food addiction.
Level of evidence: Level V, Opinions of authorities, based on descriptive studies, narrative reviews, clinical experience, or reports of expert committees.
Forschendes Lernen im Lehramtsstudium Biologie. Dokumentarische Rekonstruktionen studentischer Experimentierprozesse
Authors: Olschewski Petra , Herzmann Petra , Schlüter Kirsten 
Published: February 2023

ZusammenfassungForschendes Lernen in den Naturwissenschaften intendiert, dass Lernende den wissenschaftlichen Erkenntnisprozess selbst durchlaufen, um ihre Problemlösefähigkeiten zu schulen und ein Verständnis von Naturwissenschaft als Disziplin zu entwickeln. Wie sich die Gruppenarbeitsprozesse von Lernenden beim Experimentieren im Vergleich zu den programmatischen Erwartungen an das Forschende Lernen gestalten, ist die Fragestellung der vorliegenden Studie. Untersucht werden Experimentierprozesse von Lehramtsstudierenden des Faches Biologie. Bereits im Studium sind curriculare Angebote Forschenden Lernens vorgesehen, um angehenden Lehrpersonen eigene Erfahrungen und deren systematische Reflexion im Hinblick auf die spätere Anleitung forschungsbasierter Lernformen zu ermöglichen. Mittels der Dokumentarischen Methode streben wir an, die in-situ-Prozesse des Experimentierens – im Verhältnis zu mit der Aufgabenbearbeitung intendierten fachdidaktischen Zielen – zu rekonstruieren. Untersucht werden die handlungsleitenden Orientierungen der Studierendengruppen sowohl hinsichtlich der fachlichen Erkenntniswege als auch in Bezug auf ihre Interaktionsmodi. Im Ergebnis zeigen die Analysen für die Gruppen unterschiedliche Zugänge zur gestellten Aufgabe, die sich kontrastiv als hypothesen- und materialbasiert unterscheiden lassen. Hinsichtlich der Gruppeninteraktion können einvernehmliche und aushandlungsorientierte Modi rekonstruiert werden. Diskutiert werden die vorliegenden Befunde im Hinblick auf die Zielsetzungen Forschenden Lernens in den Naturwissenschaftsdidaktiken sowie den institutionellen Kontext der universitären Lehrer*innenbildung.
Performance and mechanism of bentonite in suppressing methane explosions in a pipeline network
Authors: Fengxiao Wang , Jinzhang Jia , Xiuyuan Tian 
Published: February 2023

AbstractMethane explosions threaten the safety of industrial security in modern society. To suppress such explosions, experiments were made through using different masses of bentonite power driven by CO2 within a pipe network set up in an independent way. The three factors, including the peak over-pressure of an explosion, the index of the explosion power, and the time length within which the first wave of flames reached the pipe network’s outlet, were measured to evaluate the performance. Moreover, an analysis on the mechanism of suppressing explosions was also conducted. According to the results, a gradual increase of the powder mass from 20 to 50 g could promote the effect of explosion suppression, but a further increase from50 g to 60 g only led to a slight improvement of the performance. Thus, it was concluded that the use of 50 g of bentonite powder worked best for the suppression of methane explosions when environmental conservation, energy saving as well as practicality were all taken into consideration. What was found in this study is supposed to shed theoretical light on how to transport methane safely with disaster risks reduced effectively.
Frictional stability and permeability evolution of fractures subjected to repeated cycles of heating-and-quenching: granites from the Gonghe Basin, northwest China
Authors: Cui Li , Zhang Fengshou , An Mengke , Zhuang Li , Elsworth Derek , Zhong Zhen 
Published: February 2023

AbstractFluid injection into enhanced geothermal system (EGS) reservoirs can reactivate subsurface fractures/faults and trigger earthquakes—requiring that frictional stability and permeability evolution characteristics are adequately evaluated. This behavior potentially becomes more complicated when the impacts of temperature and cycled thermal stresses, and the resulted damage accumulation on both stability and transport characteristics are getting involved. We conducted coupled shear-flow experiments on saw-cut fractures recovered from an analog surface outcrop representative of a reservoir at 2450 m in the Gonghe Basin of northwestern China. The rocks were subjected to variable numbers of repeated heating-quenching (25-180-25 °C) cycles for shear-flow experiments at an effective stress of ~ 3 MPa and with velocity stepped between 10-1-10-1-10 μm/s. The smooth fractures return frictional coefficients in the range ~ 0.69 to 0.72 and are little affected by the thermal cycling. The frictional stability parameter (a–b) decreases and the instantaneous permeability increases with an increase in the number of heating-quenching cycles, during which intergranular and intragranular microcracks were generated in fracture surface. The above results indicate that the heating-quenching cycles during hydraulic fracturing of geothermal reservoir could affect both the fracture frictional instability and permeability evolution.
Learning Weight Signed Network Embedding with Graph Neural Networks
Authors: Lu Zekun , Yu Qiancheng , Li Xia , Li Xiaoning , Yang Qinwen 
Published: February 2023

AbstractNetwork embedding aims to map nodes in a network to low-dimensional vector representations. Graph neural networks (GNNs) have received much attention and have achieved state-of-the-art performance in learning node representation. Using fundamental sociological theories (status theory and balance theory) to model signed networks, basing GNN on learning node embedding has become a hot topic in signed network embedding. However, most GNNs fail to use edge weight information in signed networks, and most models cannot be directly used in weighted signed networks. We propose a novel signed directed graph neural networks model named WSNN to learn node embedding for Weighted signed networks. The proposed model reconstructs link signs, link directions, and signed directed triangles simultaneously. Based on the network representations learned by the proposed model, we conduct link sign prediction in signed networks. Extensive experimental results in real-world datasets demonstrate the superiority of the proposed model over the state-of-the-art network embedding algorithms for graph representation learning in signed networks.
Feature selection on quantum computers
Authors: Mücke Sascha , Heese Raoul , Müller Sabine , Wolter Moritz , Piatkowski Nico 
Published: February 2023

AbstractIn machine learning, fewer features reduce model complexity. Carefully assessing the influence of each input feature on the model quality is therefore a crucial preprocessing step. We propose a novel feature selection algorithm based on a quadratic unconstrained binary optimization (QUBO) problem, which allows to select a specified number of features based on their importance and redundancy. In contrast to iterative or greedy methods, our direct approach yields higher-quality solutions. QUBO problems are particularly interesting because they can be solved on quantum hardware. To evaluate our proposed algorithm, we conduct a series of numerical experiments using a classical computer, a quantum gate computer, and a quantum annealer. Our evaluation compares our method to a range of standard methods on various benchmark data sets. We observe competitive performance.
The Costs and Benefits of Mindfulness and Reappraisal in Daily Life
Authors: Wenzel Mario , Blanke Elisabeth S. , Rowland Zarah , Brose Annette 
Published: February 2023

Abstract
Reappraisal and mindfulness represent two fundamentally different but interconnected ways of dealing with one’s emotions: whereas reappraisal is aimed at changing one’s thoughts and emotions, mindfulness is aimed at not immediately changing, but appreciating them. Despite this difference, prior research has shown that both are beneficial for one’s affective well-being. However, research on the spontaneous use of reappraisal and mindfulness in daily life found that they might be differentially associated with positive and negative affect, with reappraisal and mindful attention being more strongly associated with increased positive affect and mindful acceptance with decreased negative affect. Moreover, the spontaneous use of reappraisal may be less effective than mindfulness in daily life given that it is more cognitively taxing. To compare these possibly different benefits (i.e., change in positive and negative affect) and costs (i.e., feeling depleted), we re-analyzed two experience sampling studies (N = 125 and N = 179). Regarding benefits, endorsing reappraisal and mindful attention was significantly associated with increases in positive affect, whereas endorsing mindful acceptance was significantly associated with decreases in negative affect. Regarding costs, we found that endorsing reappraisal led to more depletion and that reappraisal was selected less often than mindfulness in daily life. Our results demonstrate the importance of assessing not only the different benefits but also the costs of emotion regulation in daily life.
Policy-Based Holistic Application Management with BPMN and TOSCA
Authors: Calcaterra Domenico , Tomarchio Orazio 
Published: February 2023

AbstractWith the wide adoption of cloud computing across technology industries and research institutions, an ever-growing interest in cloud orchestration frameworks has emerged over the past few years. These orchestration frameworks enable the automated provisioning and decommissioning of cloud applications in a timely and efficient manner, but they offer limited or no support for application management. While management functionalities, such as configuring, monitoring and scaling single components, can be directly covered by cloud providers and configuration management tools, holistic management features, such as backing up, testing and updating multiple components, cannot be automated using these approaches. In this paper, we propose a concept to automatically generate executable holistic management workflows based on the TOSCA standard. The practical feasibility of the approach is validated through a prototype implementation and a case study.
Historical demography and climatic niches of the Natal multimammate mouse (Mastomys natalensis) in the Zambezian region
Authors: Hánová Alexandra , Bryja Josef , Goüy de Bellocq Joelle , Baird Stuart J. E. , Cuypers Laura , Konečný Adam , Mikula Ondřej 
Published: February 2023

AbstractThe Natal multimammate mouse (Mastomys natalensis) is the most widespread rodent species in sub-Saharan Africa, often studied as an agricultural pest and reservoir of viruses. Its mitochondrial (Mt) phylogeny revealed six major lineages parapatrically distributed across open habitats of sub-Saharan Africa. In this study we used 1949 sequences of the mitochondrial cytochrome b gene to elaborate on distribution and evolutionary history of three Mt lineages inhabiting the open habitats of the Zambezian region (corresponding roughly to the African savannas south of the Equator). We describe in more detail contact zones between the lineages—their location and extent of co-occurrence within localities—and infer past population trends. The estimates are interpreted in the light of climatic niche models. The lineages underwent reduction in effective population size during the last glacial, but they spread widely after that: two of them after the last glacial maximum and the last one in mid-Holocene. The centers of expansion, i.e., possible long-term savanna refugia, were estimated to lie close to the Eastern Arc Mountains and lakes of the Great African Rift, geomorphological structures likely to have had long-term influence on geographical distribution of the lineages. Environmental niche modeling shows climate could also affect the broad scale distribution of the lineages but is unlikely to explain the narrow width of the contact zones. The intraspecific Mt differentiation of M. natalensis echoes phylogeographic patterns observed in multiple co-distributed mammal species, which suggests the mammal communities in the region are shaped by the same long-term processes.
Pepino mosaic virus antagonizes plant m6A modification by promoting the autophagic degradation of the m6A writer HAKAI
Authors: He Hao , Ge Linhao , Li Zhaolei , Zhou Xueping , Li Fangfang 
Published: February 2023

AbstractAutophagy plays an active anti-viral role in plants. Increasing evidence suggests that viruses can inhibit or manipulate autophagy, thereby winning the arms race between plants and viruses. Here, we demonstrate that overexpression of an m6A writer from Solanum lycopersicum, SlHAKAI, could negatively regulate pepino mosaic virus (PepMV) infection, inhibit viral RNA and protein accumulations by affecting viral m6A levels in tomato plants and vice versa. The PepMV-encoded RNA-dependent RNA polymerase (RdRP) directly interacts with SlHAKAI and reduces its protein accumulation. The RdRP-mediated decreased protein accumulation of SlHAKAI is sensitive to the autophagy inhibitor 3-methyladenine and is compromised by knocking down a core autophagy gene. Furthermore, PepMV RdRP could interact with an essential autophagy-related protein, SlBeclin1. RdRP, SlHAKAI, and SlBeclin1 interaction complexes form bright granules in the cytoplasm. Silencing of Beclin1 in Nicotiana benthamiana plants abolishes the RdRP-mediated degradation of SlHAKAI, indicating the requirement of Beclin1 in this process. This study uncovers that the PepMV RdRP exploits the autophagy pathway by interacting with SlBeclin1 to promote the autophagic degradation of the SlHAKAI protein, thereby inhibiting the m6A modification-mediated plant defense responses.