bluuebunny/crossref_metadata_2025_split huggingface dataset:
Senescent cells at the crossroads of aging, disease, and tissue homeostasis
Authors: Kuehnemann Chisaka , Wiley Christopher D. 
Published: September 2023

AbstractOriginally identified as an outcome of continuous culture of primary cells, cellular senescence has moved beyond the culture dish and is now a bona fide driver of aging and disease in animal models, and growing links to human disease. This cellular stress response consists of a stable proliferative arrest coupled to multiple phenotypic changes. Perhaps the most important of these is the senescence‐associated secretory phenotype, or senescence‐associated secretory phenotype —a complex and variable collection of secreted molecules release by senescent cells with a number of potent biological activities. Senescent cells appear in multiple age‐associated conditions in humans and mice, and interventions that eliminate these cells can prevent or even reverse multiple diseases in mouse models. Here, we review salient aspects of senescent cells in the context of human disease and homeostasis. Senescent cells increase in abundance during several diseases that associated with premature aging. Conversely, senescent cells have a key role in beneficial processes such as development and wound healing, and thus can help maintain tissue homeostasis. Finally, we speculate on mechanisms by which deleterious aspects of senescent cells might be targeted while retaining homeostatic aspects in order to improve age‐related outcomes.
Racial Frontiers: Hemispheric Logics of Haitians’ Displacement and Asylum in the Americas
Authors: Balaguera Martha , Schwartzman Luisa Farah , van Isschot Luis 
Published: September 2023

AbstractWhile international asylum law includes race as the first protected category—followed by religion, nationality, particular group membership, and political opinion—Haitians’ ongoing racialised persecution and denial of refuge across the Americas reveals the failures of this framework. Drawing on academic literature, documentary evidence, and primary sources, we analyse the racial and neocolonial logics constituting Haitians’ experiences at home and as migrants through the Americas. Focusing on Brazil, Colombia, and Mexico as nodes of migration trajectories, we argue that Haitians confront a “hemispheric frontier regime”. Unlike a single border that impedes passage, this multilayered frontier regime constantly uproots Haitians, even while states evade their responsibilities vis‐à‐vis asylum seekers. Over time, mutually reinforcing frontier logics of policing, dispossession, extraction, and empire at various scales—urban, domestic, transnational—structure Haitians’ and other migrants’ racialised exclusion from rights regimes across geographies from Haiti to South, Central, and North America.
Non‐native mammals are weak candidates to substitute ecological function of native avian seed dispersers in an island ecosystem
Authors: Gawel Ann Marie , Fricke Evan , Colton Andrea , Rogers Haldre S. 
Published: September 2023

AbstractAlthough prominent examples exist of non‐native species causing substantial ecological harm, many have neutral or positive effects, including filling surrogate roles once performed by extinct native organisms. We tested the ecological roles of two non‐native mammals as seed dispersers or seed predators in Guåhan, which, due to invasive brown tree snakes (Boiga irregularis), is devoid of native seed dispersers–birds and bats. We conducted feeding trials with captive rats (Rattus spp.), which are present but uncommon due to predation by snakes, and pigs (Sus scrofa), which are abundant. We examined if and how they interacted with common forest fruits. We then compared how any gut‐passed or animal‐handled seeds germinated compared to seeds left in whole fruit or depulped seeds. Rats and pigs interacted with most of the fruits and seeds (>80%) that they were fed. Of those, most seeds were destroyed—78% for rats and 90% for pigs, across both native and non‐native plant species. Compared to seeds germinating within whole fruits, rats improved germination of the seeds that they handled without ingesting, while pigs diminished the germination of seeds that they handled. The small percentage of seeds (approximately 1.5% for rats and 5% for pigs) that survived gut passage germinated in higher proportions than those in whole fruits. Percentages of seed survival to germination are lower than found in similar studies with native avian frugivores. Our results indicate that pigs and rats have mixed effects on seeds, but are not suitable surrogates for native seed dispersers.
Peripheral blood inflammatory biomarkers dynamics reflect treatment response and predict prognosis in non‐small cell lung cancer patients with neoadjuvant immunotherapy
Authors: Huai Qilin , Luo Chenyu , Song Peng , Bie Fenglong , Bai Guangyu , Li Yuan , Liu Yang , Chen Xiaowei , Zhou Bolun , Sun Xujie , Guo Wei , Gao Shugeng 
Published: September 2023

AbstractNeoadjuvant immunotherapy has significantly changed the therapeutic approach for treating patients with surgically resectable non‐small cell lung cancer (NSCLC). Here, peripheral blood inflammation‐based biomarkers as well as previously less focused eosinophil fraction, modified Glasgow prognostic score (mGPS), and prognostic nutritional index (PNI) were systematically included to comprehensively analyze their potential in predicting neoadjuvant immunotherapy efficacy and prognosis. We enrolled 189 patients (94 in training and 95 in validation cohorts) with stage I–III B surgically resectable NSCLC treated with neoadjuvant immunotherapy from the National Cancer Center of China. Baseline and post‐treatment eosinophils fraction, neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), systemic immune‐inflammation index (SII), monocyte‐to‐lymphocyte ratio (MLR), PNI, mGPS, and their changes were calculated and analyzed for correlation with neoadjuvant immunotherapy efficacy and prognosis. In patients in the major pathological response (MPR) group, the post‐treatment eosinophil fraction was significantly high, and NLR, PLR, SII, and MLR were significantly lower compared to the non‐MPR group in both the training and validation cohorts. The receiver operating characteristic curve showed that post‐treatment, eosinophil fraction and SII and their changing were two of the most important factors. Univariate and multivariate logistic regression analyses showed that post‐treatment eosinophil fraction, SII, mGPS, and ΔSII could independently predict MPR in patients treated with neoadjuvant immunotherapy. Survival analysis showed a significant correlation between high post‐treatment NLR, PLR, SII, mGPS, and their changes in ΔNLR and ΔSII elevation with poor overall survival and event‐free survival of patients. Our results suggest that inflammatory biomarkers could predict the patient's response to neoadjuvant immunotherapy and prognosis.
Design and synthesis of novel 1,2,3,4‐tetrazines as new anti‐leukemia cancer agents
Authors: Eyilcim Oznur , Gunay Fulya , Gunkara Omer Tahir , Ng Yuk Yin , Ulucan Ozlem , Erden Ihsan 
Published: September 2023

AbstractA series of novel 1,2,3,4‐tetrazines were designed and synthesized. 1H‐NMR spectroscopy, 13C NMR spectroscopy, and HRMS were used to determine the structures of this novel compounds. Computational approaches suggested that DHFR is a putative target for the newly synthesized 11 compounds. Extensive molecular dynamics simulations followed by molecular docking simulations were employed to evaluate DHFR as a potential target protein. The anticancer activities of the compounds were evaluated against five different types of leukemia cell lines (Jurkat, Nalm‐6, Reh, K562, and Molt‐4) and one non‐leukemic cell line (Hek293T) by MTT test in vitro and imatinib was used as a control drug. Among these compounds, 3a exhibited the best activity against all the leukemic cell lines, except Reh cell line. For Nalm‐6, K562, Jurkat, and Molt‐4 cell lines, IC50 values were found to be 15.98, 19.12, 23.15, and 25.80 μM, respectively. Our work focuses on the synthesis of original and novel 1,2,3,4‐tetrazine derivatives while contributing to the ongoing effort to discover more potent new antileukemia agents.
Baicalein, a component of banxia xiexin decoction, alleviates CPT‐11‐induced gastrointestinal dysfunction by inhibiting ALOX15‐mediated ferroptosis
Authors: Pei Jingbo , Zou Yuanyuan , Zhou Wenying , Wang Yakun 
Published: September 2023

AbstractBaicalein, one of the active ingredients of banxia xiexin decoction, has good therapeutic efficacy in treating diarrhea and improving gastrointestinal dysfunction. The role and mechanism of Baicalein on irinotecan (CPT‐11)‐induced gastrointestinal dysfunction are the focus of this study. Concretely, CPT‐11 induced delayed diarrhea rat model and intestinal epithelial cell (IEC)‐6 cell injury model with Baicalein treatment as needed. Colonic pathological changes were analyzed by hematoxylin–eosin staining, and inflammatory factor expressions in serum were determined by enzyme‐linked immunosorbent assay. Immunohistochemistry and western blot were performed to quantify ferroptosis‐related protein expressions. Thiobarbituric acid reactive substances (TBARS) kits and colorimetric assay kit were applied to detect lipid peroxidation levels and Fe2+ content, respectively. In vitro experiments also included quantitative real‐time polymerase chain reaction, cell counting kit‐8, and C11 BODIPY staining. CPT‐11 induced aggravation of intestinal tissue damage, inflammatory factor release, Fe2+ accumulation, upregulation of lipid peroxidation and 15‐Lipoxygenase (ALOX15) expression, and downregulation of glutathione peroxidase 4 (Gpx4) and SLC7A11 in vivo in rats; however, Baicalein dose‐dependently reversed the effects of CPT‐11. Baicalein elevated cell viability, reduced lipid peroxidation and Fe2+ accumulation, and elevated Gpx4 and SLC7A11 levels, whereas ALOX15 overexpression reversed the effects of Baicalein on a CPT‐11‐induced IEC‐6 cell injury model. In conclusion, Baicalein plays a mitigating role in CPT‐11‐induced delayed diarrhea via ALOX15‐mediated ferroptosis.
The risk of attention‐deficit hyperactivity disorder among children with congenital heart disease: A systematic review and meta‐analysis
Authors: Tang Jiapeng , Ou Jun , Chen Yige , Li Liuxuan , Liu Hanjun , Sun Mengting , Luo Manjun , Zhong Taowei , Wang Tingting , Wei Jianhui , Chen Qian , Qin Jiabi 
Published: September 2023

AbstractBackgroundAlthough current treatments are effective in dealing with congenital heart disease (CHD), non‐cardiac comorbidities such as attention‐deficit hyperactivity disorder (ADHD) have received widespread attention. The purpose of this systematic review and meta‐analysis is to assess the risk of ADHD associated with CHD.MethodsThe literature search was carried out systematically through eight different databases by the end of September 2022. Either a fixed‐ or a random‐effects model was used to calculate the overall combined risk estimates. The heterogeneity of the studies was assessed by the Cochran Q test and the I2 statistic. Subgroup and sensitivity analyses were used to explore the potential sources of heterogeneity.ResultsEleven studies were included in this study, which involved a total of 296 741 participants. Our study showed that the children with CHD were at a significantly increased risk of ADHD compared with the reference group (OR = 2.98, 95% CI: 2.18–4.08). The results were moderately heterogeneous. These factors including study design, geographic region and study quality were identified as the first three of the most relevant heterogeneity moderators by subgroup analyses. Sensitivity analysis yielded consistent results. There was no evidence of publication bias.ConclusionsThe present study suggests that CHD children have a significantly higher risk of ADHD when compared with those without CHD. Early identification and intervention of ADHD is important to reduce its symptoms and adverse effects; therefore, clinicians should increase screening for ADHD in children with CHD and intervene promptly to reduce its effects whenever possible.
Capital flow management and monetary policy to control credit growth
Authors: Zehri Chokri , Madjd‐Sadjadi Zagros 
Published: September 2023

AbstractThis paper examines whether capital flow management and monetary policies effectively reduce credit growth in emerging market economies in the presence of both conventional and unconventional monetary policy actions undertaken by advanced economies. We apply a dynamic panel model with fixed effects to a sample of 21 emerging market economies from 2000 to 2020 using quarterly data and more continuous variables than in other studies rather than limiting the variability using proxies. We find that capital controls and macroprudential regulation, as tools of capital flow management policy, moderate credit growth. This effect is particularly shown in countries with tighter monetary conditions. Our main findings highlight the useful role of coordinating capital flow management and monetary policies. This role stands for both fixed and flexible exchange rate regimes. Lastly, we find capital flow management and monetary policies manage to control credit in normal periods, but their coordination is less effective during crises and high volatility periods. Robustness checks suggest that these findings are stable across alternative proxies used in the literature, thus providing additional support for the validity of our results.
Effect of intra‐alveolar delivery of Frondoside A on inflammatory response of delayed tooth replantation
Authors: Herr Lar , Ye Ju Ri , Kang Sang Wook , Ro Sang Tae , Chae Yong Kwon , Lee Ko Eun , Kim Mi Sun , Jih Myeong Kwan , Lee Chunui , Choi Sung Chul , Nam Ok Hyung 
Published: September 2023

AbstractBackground/AimFrondoside A is a sea cucumber extract which is well known for its anti‐inflammatory and immunomodulatory properties. The purpose of this study was to evaluate the effect of Frondoside A application in the alveolar socket on inflammatory responses after delayed replantation in rat teeth.Materials and MethodsHuman periodontal ligament cells were cultured and exposed to Frondoside A. Cell‐counting kit‐8 assay was performed to evaluate the cell viability and nitric oxide assay was performed to assess the anti‐inflammatory effect of Frondoside A. Molars were extracted from 32 Sprague–Dawley rats and randomly divided into control and Frondoside A groups. After 30 min of extra‐oral dry time, molars were replanted. In the Frondoside A group, Frondoside A solution was applied in the alveolar socket before replantation. The animals were sacrificed after 28 days and histologically and immunohistochemically evaluated.Results0.5 μM Frondoside A showed higher cellular viability at 6 h and lower production of nitric oxide compared with other Frondoside A solutions (p < .05). The Frondoside A group demonstrated lower inflammatory resorption scores in both middle 1/3 and apical 1/3 of root compared to the control group (p < .05). The Frondoside A group showed lower levels of expression in both cathepsin K and CD45 compared with the control group (p < .05).ConclusionsWithin the limits of this study, intra‐alveolar delivery of Frondoside A alleviates inflammatory root resorption in delayed replantation of rat teeth.
How does the dominant stakeholder strategically manage an innovative public policy? Evidence from the London congestion charge
Authors: Chen Jason C. , Roberts Robin W. 
Published: September 2023

AbstractPrior studies have examined various economic, environmental, and social impacts of the London congestion charge (LCC). However, few studies have investigatedhowthe Transport for London (TfL) managed the LCC in all stages of its policy. Without active, strategic management of policies, stakeholders affected may doubt the policies’ legitimacy and reduce policy effectiveness. Thus, examining the means utilized to achieve effective policy management is critical and can potentially influence the development and management of future policies. This study adapts Mitchell et al.’s stakeholder typology to studyhowthe TfL, as part of the management of, and as the dominant stakeholder in, environmental regulations in London, strategically managed the LCC via their own efforts to exert power, establish legitimacy, and claim urgency. Relying on Yin, we analyze publicly available data to show how the TfL actively managed the LCC to ensure its sustainability as policy. The TfL primarily used tactics to maintain and enhance the LCC's legitimacy with authoritative power and fears of unproven urgency to influence other stakeholders. Results have practical implications for policymakers contemplating policy reforms and shed additional light on less‐discussed latent factors regarding policy management. This study contributes to the literature by applying stakeholder theory to the domain of policy reform, administration, and management. Our findings have policy implications as policymakers may benefit from learning the tactics examined in this study to assess their policy management and administration. Lastly, through our discussion and conclusions, we reflect on our findings to encourage research on policy management.
Training parenting plan evaluators: Looking towards the future
Authors: Kaufman Robert L. , Deutsch Robin M. , Harris‐Britt April 
Published: September 2023

AbstractStandards of practice for parenting plan evaluations continue to evolve, informed by advances in research and the development of innovative, evidence‐based approaches to assessment and intervention. Parenting plan evaluators are asked to inform the court, parents, and other professionals on how to address the complex needs of increasingly diverse families amid reorganization, high conflict, and crisis. How can we attract and properly train new mental health professionals to do important work in an increasingly strained adversarial system? How can evaluators keep up with these advances over the course of their careers? How can they deepen and refine their skills to work with a diverse array of individuals, family constellations and an enormous range of family circumstances? And how can evaluators care for their own well‐being and their colleagues? In this article, the authors describe a multi‐dimensional approach to training both new and experienced custody evaluators that includes imparting baseline knowledge on how to conduct quality parenting plan evaluations as a starting point. We discuss a variety of modalities and approaches that can enable evaluators to deepen and expand their skills over the years, contribute to the diverse community of family law professionals, and manage the exceptional demands of working in this field.
Cost‐effectiveness analysis of full versus selective root canal retreatment
Authors: Brochado Martins João Filipe , Hagay Shemesh , Herbst Sascha Rudolf , Falk Schwendicke 
Published: September 2023

AbstractAimSelective root‐canal retreatment has been proposed as an alternative to full retreatment in multirooted, root‐canal‐filled teeth with evidence of apical pathology, where only the affected root(s) is retreated. Whilst this option may save costs initially, failures and retreatments may compensate for these initial savings. We assessed the cost‐effectiveness of full versus selective root‐canal retreatment using data from a recent clinical pilot study, employing a modelling approach.MethodologyA Markov model was constructed to follow up a previously root‐canal treated maxillary molar with apical pathology on a single root (mesio‐buccal), receiving either selective or full root‐canal retreatment. A private‐payer perspective in Dutch health care was adopted. Permanent molar teeth with apical lesions on the mesial root were simulated over the lifetime of initially 50‐year‐old patients. Teeth could have endodontic complications and require interventions such as retreatment or tooth extraction and replacement. Costs were calculated based on the Dutch dental fee catalogues. Monte‐Carlo microsimulations were performed to assess lifetime costs and effectiveness (measured as tooth retention time), and the resulting cost‐effectiveness. Probabilistic joint uncertainty and sensitivity analyses were performed, and cost‐effectiveness at different willingness‐to‐pay‐thresholds was evaluated.ResultsIn the base‐case scenario, selective retreatment was less costly (2137; 2.5%–97.5% percentiles: 1944–2340 Euro) and more effective (19.6; 18.3–20.8 Years) than full retreatment (2495; 2305–2671 Euro; 16.5; 15.2–17.9 Years) in 100% of the simulations and regardless of the willingness‐to‐pay threshold. Only in a worst case scenario was selective retreatment more costly, but remained more effective.ConclusionsSelective retreatment, when clinically applicable, is likely to be more cost‐effective than full retreatment in endodontically treated molars with persistent apical periodontitis. Our results should be interpreted with caution because the quality of the underlying data is limited.
Valorisation of asparagus pruning waste as a new ingredient to improve pasta quality properties
Authors: Sousa da Silva Dario , Saraiva Bianka Rocha , Lazzari Anderson , Cestario Andresa Carolina de Oliveira , de Oliveira Mariana Carla , Bruschi Marcos Luciano , Rosa Cassia Inês Lourenzi Franco , Matumoto Pintro Paula Toshimi 
Published: September 2023

SummaryAsparagus pruning leaves are waste that can be reused to enrich foods due to their functional and nutritional properties. This study aimed to evaluate the asparagus pruning waste flour (AF) reuse as a partial replacement for wheat flour in pasta production subjected to different drying temperatures. AF addition up to 10% (w/w) to pasta increased its bioactive compounds and antioxidant activity, but these decreased at high drying temperatures. Pasta with AF and dried at high temperatures reduced optimal cooking time (by up to 53%), water absorption (by up to 43%) and cooking loss (by up to 72%). In the texture, high drying temperature increased its breaking and cutting strength of pasta, while AF enrichment decreased these properties. The results showed that AF can be used as a partial replacement for wheat flour in pasta, adding quality and functionality, showing its potential as a sustainable ingredient for food enrichment.
Performance evaluation the new automated Atellica Hema 580 hematology analyzer
Authors: Schapkaitz E. , Baiden A. , Raburabu S. 
Published: September 2023

AbstractIntroductionThe Atellica Hema (Siemens Healthineers, Tarrytown, NY, USA) is a new generation multi‐parameter analyzer for full blood count, 6‐part differential and reticulocyte testing by impedance variation and fluorescence flow cytometry. In this study, we verified the whole blood and limited body fluid modes of the Atellica Hema 580.MethodsWe evaluated precision, linearity, carry‐over, throughput and performed a method comparison to assess the performance of the Atellica Hema 580. For comparison of the Atellica Hema 580 with the Sysmex XN‐1000 (Sysmex, Kobe, Japan), 140 samples from adult and pediatric patients including both normal and abnormal hematology profiles were analyzed in parallel.ResultsThe Atellica Hema 580 demonstrated acceptable imprecision within the manufacturer's specifications for whole blood and body fluid modes, good linearity for high and low ranges and no significant carryover. The full blood count, differential and reticulocyte correlated well with the Sysmex XN‐1000, except for mean cell hemoglobin concentration, basophil and large immature cells. The optical platelet count, reflexed in 34 samples with a platelet count <150 × 109/l, showed a strong correlation with the fluorescent platelet count on the Sysmex XN‐1000. The morphology flagging efficiency was 92% for white blood cells, 95% for red blood cells and 87% for platelets.ConclusionThe Atellica Hema 580 showed good analytical performance and workflow efficiency for a wide range of patient samples.