bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental evidences and calculation of the limited penetration of acyl chloride reagent in a dense layer of PVA coated on a paperboard after chromatogeny grafting
Authors: Bru François , Bartolami Eline , Monot Claire , Molina-Boisseau Sonia , Lancelon-Pin Christine , Schelcher Matthieu , Martinez Philippe , Heux Laurent 
Published: April 2023

Abstract

Paper board have very poor barrier properties to water, water vapour and grease that can be improved by coating a layer, in this work of PolyVinylAlcohol (PVA), which exhibits very good barrier to grease but limited resistance to water and water vapour. Chromatogeny is an hydrophobisation technique that allows to confer better barrier to water and water vapour with a technology implementable at the industrial scale. Several passages can be applied on the coated layer to improve the grafting densities. However, little is known about the molecular mechanisms and the distribution of the reagent among the coated layer or if it modified also the paper board. In this work, we demonstrated that the modification proceeds from the surface to the interior of the PVA layer by developing an imaging technique based on the labelling with Osmium Tetroxide (OsO4) of the double bond of an oleyl acyl chloride used as an unsaturated hydrophobisation agent. The result is a bright tagging of the modified PVA layer strictly limited to the upper surface, as revealed by SEM images. Calculations made on simple assumptions on the volume expansion due to the modification have been confronted to the experimental data, i.e. measurements of the thickness of the grafted layers. The results showed that in our experimental conditions, the reagent penetrates in a zone strictly restricted to the upper part of the PVA layer and never reached the paper board. Moreover, the second passage does not increase significantly the penetration depth of the reagent, but allows increasing notably the hydrophobicity of the grafted material, as shown by Cobb measurements. Paper board remains intact in all the experimental situations explored at pilot scale.
Eating disorders and emotional dysregulation are associated with insufficient weight loss after bariatric surgery: a 1-year observational follow-up study
Authors: Barbuti Margherita , Carignani Giulia , Weiss Francesco , Calderone Alba , Fierabracci Paola , Salvetti Guido , Menculini Giulia , Tortorella Alfonso , Santini Ferruccio , Perugi Giulio 
Published: April 2023

Abstract
Purpose

subjects with obesity, especially those seeking bariatric surgery, exhibit high rates of mental disorders and marked psychopathological traits. The primary objective of this prospective, non-interventional study was to investigate whether the presence of different psychiatric disorders, attention deficit/hyperactivity (ADHD) symptomatology and emotional dysregulation influenced weight loss at 1-year follow-up after surgery.

Methods

the sample included 99 subjects consecutively referred for pre-surgical evaluation. Psychiatric diagnoses and ADHD symptomatology assessment were made through structured interviews; emotional dysregulation traits were investigated through self-report questionnaires. After surgery, weight and obesity-related comorbidities were monitored during a 1-year follow-up.

Results

76 participants underwent surgery, of whom 65 could be reevaluated after 1 year. Subjects with insufficient weight loss (excess body mass index loss ≤ 53%, n = 15) had more frequent lifetime binge eating disorder and comorbid mood and binge eating disorders than subjects with more favorable post-surgical outcome. Additionally, they scored higher on both physician-administered and self-report scales assessing negative emotion dysregulation, which represents a nuclear symptom of ADHD in adults. This latter psychopathological trait was found to be a predictor of reduced weight loss at the logistic regression analysis, along with older age and higher preoperative excess body mass index.

Conclusion

mood and binge eating disorders, as well as the presence of affective instability and emotional over-reactivity, seem to be associated with a worse outcome after bariatric surgery. To confirm the possible influence of psychopathology on long-term outcome after bariatric surgery, further studies with larger samples and longer follow-up are urgently needed.
Level of evidence: V, prospective descriptive study
Factors associated with postpartum initiation of anti-hypertensive medication after hospital discharge among individuals with hypertensive disorders of pregnancy in a remote monitoring program
Authors: Hauspurg Alisse , Venkatakrishnan Kripa , Collins Latima , Countouris Malamo , Larkin Jacob , Quinn Beth , Kabir Nuzhat , Lemon Lara , Simhan Hyagriv 
Published: April 2023

Abstract
Importance

Following a hypertensive disorder of pregnancy, hypertension can worsen in the postpartum period following hospital discharge. Risk factors for hypertension exacerbation and associated outcomes have not been well characterized.

Objective

We sought to identify risk factors and characterize outcomes for individuals requiring initiation of anti-hypertensive medication following hospital discharge postpartum through our hospital system’s remote blood pressure management program.

Design

We performed a cohort study of individuals delivered between 9/2019-6/2021 and enrolled in our remote blood pressure monitoring program, which utilizes standardized protocols for anti-hypertensive medication initiation postpartum.

Setting

Postpartum unit at a referral hospital

Participants

Population-based sample of individuals with a hypertensive disorder of pregnancy (HDP, preeclampsia or gestational hypertension) and no pre-pregnancy hypertension.

Exposure

Anti-hypertensive medication initiation timing: no anti-hypertensive medications, initiation prior to hospital discharge postpartum, and initiation after hospital discharge postpartum

Main outcomes

Postpartum readmission and emergency room visits

Results

Of 2,705 individuals in our cohort, 1,458 (54%) required no anti-hypertensive medications postpartum, 637 individuals (24%) were discharged on anti-hypertensive medications, and 610 (23%) required initiation of anti-hypertensive agents after discharge. Utilizing an inpatient threshold of ≥ 150/100 mmHg in line with current obstetric guidelines for medication initiation postpartum fails to identify 385 (63%) of individuals who required medication initiation after discharge. These individuals had higher home blood pressures, increased odds of Emergency Room visits [aOR 2.22 (95%CI 1.65–2.98)] and hospital readmissions postpartum [aOR 5.73 (95%CI 3.72–8.82)] compared with individuals discharged on no medications.

Conclusions and Relevance

Over 20% of individuals with hypertensive disorders of pregnancy required initiation of anti-hypertensive medications after hospital discharge. Current blood pressure guidelines for medication initiation fail to identify the majority of these individuals during delivery hospitalization. These data support the critical role of remote blood pressure monitoring programs and highlight the need for improved tools for risk stratification and liberalization of thresholds for medication initiation postpartum.
Lipid Mediators and Severity of Psoriasis
Authors: Al-Ashoor Zainab A. , Haddad Nazar S. , Al-Hamdi Khalil I. 
Published: April 2023

Abstract
Psoriasis is one of the most common chronic inflammatory skin diseases resulting from a complex genetic background with environmental triggers. The bioactive Lipid mediators (12-hydroxyeicosatetraenoic acid (12-HETE) and 13-hydroxy octadecadienoic acid (13-HODE)) that generated involved in a variety of physiological and pathological processes. The study aims to assess the levels of bioactive lipid mediators (12- HETE and 13-HODE) in the serum and skin of psoriatic patients compared with healthy individuals and to study the association between the levels of bioactive lipid mediators in psoriatic patients with psoriasis severity measured by PASI score. Thirty-one patients with psoriasis were enrolled in the study, with 20 age and sex-matched apparently healthy subjects.The type of psoriasis and PASI score were assessed for psoriatic patients. Serum levels of 12-HETE, 13-HODE and other investigations were determined in psoriatic and healthy control groups, and the skin levels of 12-HETE and 13-HODE were also determined in lesional and non-lesional skin biopsies of psoriatic patients. There were statistically significant differences in the mean serum levels of 12-HETE and 13-HODE among the three psoriasis severity groups with (P =0.002, P =0.04), respectively. The serum levels of 12-HETE and 13-HODE were positively correlated with increasing psoriasis severity measured by PASI scorewith (r = 0.86, p =0.001), (r=0.87, p=0.001), respectively. In conclusion, The level of both lipid mediators (12-HETE and 13-HODE) had significantly increased in the serum of psoriatic patients with a significant positive correlation with the severity of psoriatic disease as assessed by the PASI scoring system.
Overall performance evaluation of an urban water supply system: a case study of Debre Tabor Town in Ethiopia
Authors: Tekile Andinet , Legesse Yezina Shiferaw 
Published: April 2023

Abstract
Urban water utilities in Ethiopia, including Debre Tabor Town, commonly suffer from an intermittent water supply, water quality issues, poor service delivery, and other problems. Thus, the main focus of this study was to evaluate the actual performance level of the water supply system of the town based on hydraulic efficiency, quality, cost recovery and customer satisfaction. The water distribution system status was measured by using reliability, resilience, and vulnerability as performance indicators. Weightage Arithmetic Water Quality Index (WAWQI) and household-based questionnaires were used to evaluate the water quality and customer satisfaction, respectively. Pressure and velocity-based sustainability index of 0.614 and 0.132 showed acceptable and unacceptable water supply status, respectively, and overall moderate sustainability. Results of the WAWQI revealed that more than half of the sampled tap waters were either poor or unfit for drinking purposes. The comparison of income collected from customers and the water production costs of the utility showed that only 34.31% of production cost is covered by customers. Generally, 62.6% of the society confirmed that they are unsatisfied with the existing water supply system. Thus, to improve the performance, it is recommended to address all the major social, economic, environmental and technical problems.
Phenyliodine(III)diacetate (PIDA): Applications in Rearrangement/Migration Reactions
Authors: Alam M. Mujahid , Bollikolla Hari Babu , Amanullah Mohammed , Hussein Mohamed , Varala Ravi 
Published: April 2023

Abstract:
One of the most widely utilized hypervalent iodines used as an oxidizing agent in organic
chemistry is (dialcetoxyiodo)benzene (PhI(OAc)2), also known as (DAIB), phenyliodine(III)
diacetate (PIDA). In this mini-review, PIDA is highlighted in relation to its applications in organic
synthesis involving rearrangement/migration reactions along with their interesting mechanistic
aspects from the summer of 2015 to the present.
Compounds with Anti-Alzheimer Activity Isolated for the First Time from
Melaleuca leucodendron (L.) Leaves
Authors: Abdel Elkarim Asmaa S. , Ahmed Amal H. , ELsayed Wael M. 
Published: April 2023

Objective:
To discover a drug from natural triterpenes that has no side effects and is
effective in treating Alzheimer's disease. We predict that the drug will be put on the market soon
and achieve success.

Methods::
The methanolic extract of M. leucodendron leaves was fractionated and subjected to
different chromatographic techniques to isolate two new triterpene glycosides alongside five
known compounds kaempferol 3, quercetin 4, quercetin3-O-β-D-glucopyranoside 5, kaempferol3-
O-β-D-glucopyranoside 6 and kaempferol3-O-α-L-rhamnoside 7. The structures of compounds 1
and 2 were elucidated by spectroscopic analysis and chemical means.

Results:
Two new triterpene glycosides, 21-O-α-L-rhamnopyranosyl-olean-12-ene-3-O-[α-Lrhamnopyranosyl
(1-4) β-D-galactopyranosyl (1-4) β-D-glucouronopyranoside]1 and 21-O-α-Lrhamnopyranosyl-
olean-12-ene-3-O-[α-L-rhamnopyranosyl (1→4) β-D-galactopyra-nosyl (1→4)
β-D-galactopyranoside] 2, were isolated for the first time from 70% aqueous methanolic extract
(AME) of M. leucodendron leaves. The inhibitory activities of the said compounds toward acetylcholinesterase
(AChE) and butyrylcholinesterase (BChE) were then assayed. Both compounds
exhibited significant inhibitory activities toward the two enzymes, and evidence indicated that
compound 2 was a more effective inhibitor than compound 1.

Conclusion:
Compounds 1 and 2 have a significant role in inhibiting the enzymes acetylcholinesterase
and butyrylcholinesterase.
Review of the Chemical Composition and Biological Activities of Essential Oils from Artemisia Argyi, Artemisia Princeps, and Artemisia Montana
Authors: Yu Dan , Huang Nan‑Nan , Du Xiao‑Wei 
Published: April 2023

Background:
Artemisia argyi Lévl. et Van., Artemisia princeps Pamp., and Artemisia montana Pamp., which are the sources of mugwort, have been popular across East Asian countries for nearly 2000 years now. Essential oils are the major chemical component obtained from them, exhibiting a variety of biological activities.

Objective:
This review mainly focuses on the chemical composition and biological activities of A. argyi essential oil (AAEO), A. princeps essential oil (APEO), and A. montana essential oil (AMEO), with a special focus on their common and specific characteristics. The traditional use, dis-tribution, and botany of A. argyi, A. princeps, and A. montana have also been summarized. In addi-tion, the pharmacokinetics of AAEO was involved.

Methods:
We collected literature from online and offline databases by entering the following key-words: mugwort, wormwood, A. argyi, A. princeps, A. montana, essential oil, and volatile oil. No language limitation was present in our search.

Results:
A. argyi, A. princeps, and A. montana were used as traditional medicine, food, and health care products for a long time in Asia. They are widely distributed in most parts of China, Korea, and Japan. AAEO, APEO, and AMEO composed of monoterpenes, sesquiterpenes and their derivatives, alkanes, olefins, etc. Most of the specific compounds of AAEO were monoterpenoids, nearly half of the specific compounds of APEO were aliphatic hydrocarbons, and the sesquiterpenes were the typ-ical specific compounds of AMEO. The mugwort essential oil showed multiple biological activities, such as anti-microbial, anti-inflammatory, antioxidant, antitumor, anticoagulation, sedative, and in-secticide.

Conclusion:
The present review provided insight into the chemical composition and biological ac-tivity of AAEO, APEO, and AMEO. The comprehensive literature showed that they possessed wide application prospects in various fields. However, they should be studied in more depth. The under-lying bioactive mechanisms should be elucidated and their toxicity and quality control should be de-termined.
Synthesis of N,N-diethylaminopropylurea and Monosubstituted Urea Derivatives
from Primary Amines and Potassium Cyanate
Authors: Chang Wei-Jin , Liew Sook Yee , Tan Siow-Ping 
Published: April 2023

Abstract:
Urea derivatives are an important class of pharmacologically-active compounds due to their
ability to form hydrogen bonds with biological targets. Several synthetic pathways have been developed
to access urea derivatives, such as the metal-free and metal-catalysed carbonylation reactions of
amines and the Curtius, Hofmann, and Tiemann rearrangement reactions. This study aimed to synthesize
urea derivatives from primary amines. The urea derivatives were synthesized from primary
amines and potassium cyanate in 1M HCl aqueous solution under ambient conditions and were isolated,
followed by characterization using FTIR, DSC, and NMR (1H and 13C). A new urea derivative, N,
N-diethylaminopropylurea (6), together with N-phenylurea (1), para-tolylurea (2), orthomethoxyphenylurea
(3), para-methoxyphenylurea (4), N-benzylurea (5), and N-butylurea (7), was
successfully synthesized under acidic conditions. This work presents the synthesis and characterization
data of a newly-reported urea derivative, N, N-diethylaminopropylurea (6), and extends the substrate
scope to basic side chains in the synthesis of urea derivatives from primary amines and potassium
cyanate in water.
Synthesis and Characterization of a Julolidine-based Electro-optic Molecular
Glass
Authors: Chen Kexiang , Wang Jiexue , Li Lu , Chang Le , Yang Min , Wang Qihui , Li Zhonghui , Deng Guowei 
Published: April 2023

Aim:
Organic electro-optic (EO) materials have recently gained considerable attention owing to their advantages compared to inorganic EO materials. Among different kinds of organic EO materials, organic EO molecular glass exhibits desired prospect because of its high chromo-phore loading density and large macroscopic EO activity.

Introduction:
The objective of this study is to design and synthesize a novel organic EO molecular glass JMG utilizing julolidine moiety as the electron donor, thiophene moiety as the conjugated bridge, trifluoromethyl substituted tricyanofuran derivate (Ph-CF3-TCF) as the electron acceptor.

Methods:
The JMG’s structure was characterized through NMR and HRMS. The photophysical property, glass transition temperature, first hyperpolarizability (β) and dipole moment (μ) of JMG were determined through UV-vis spectra, DSC test and DFT calculation.

Results:
JMG’s Tg reached to 79°C and it can form high-quality optical film. The theoretical calcu-lation shows that the first hyperpolarizability (β) and dipole moment (μ) of JMG were calculated to 730×10-30 esu and 21.898 D. After connecting poling with the poling voltage of 49 V/μm at 90℃ for 10 min, the highest EO coefficient (r33) of the poled JMG films reached to 147 pm/V.

Conclusion:
A novel julolidine-based NLO chromophore with two tert-butyldiphenylsilyl (TBDPS) groups was successfully prepared and characterized. TBDPS group is introduced as the film-forming group, and it also plays the role of isolation group, which can suppress the electrostatic in-teraction between chromophores, improve the poling efficiency and further enhance the EO activity. The excellent performances endow JMG with potential applications in device fabrication.
Neurogenesis, A Potential Target for Intermittent Hypoxia Leading to
Cognitive Decline
Authors: Liu Yuxing , Tan Jin , Miao Yuyang , Zhang Qiang 
Published: April 2023

Abstract:
As a sleep breathing disorder, characterized by intermittent hypoxia (IH) and Obstructive sleep
apnea (OSA), is believed to decrease the cognitive function of patients. Many factors are thought to be
responsible for cognitive decline in OSA patients. Neurogenesis, a process by which neural stem cells
(NSCs) differentiate into new neurons in the brain, is a major determinant affecting cognitive function.
However, there is no clear relationship between IH or OSA and neurogenesis. In recent years, increasing
numbers of studies on IH and neurogenesis are documented. Therefore, this review summarizes the effects
of IH on neurogenesis; then discusses the influencing factors that may cause these effects and the
potential signaling pathways that may exist. Finally, based on this impact, we discuss potential methods
and future directions for improving cognition.
Competitive Effect of Overexpressed C-terminal of Snail-1 (CSnail) in
Control of the Growth and Metastasis of Melanoma Cells
Authors: Rostami Sadegh Paydari , Dehkordi Negar Moghare , Asgari Yazdan , Bolouri Mohammad Reza , Shayanfar Nasrin , Falak Reza , Kardar Gholam Ali 
Published: April 2023

Background::
Epithelial-to-mesenchymal transition (EMT) plays a role in the invasion
and metastasis of cancer cells. During this phenomenon, Snail can promote tumor progression by
upregulating mesenchymal factors and downregulating the expression of pro-apoptotic proteins.

Objectives::
Therefore, interventions on the expression rate of Snails may show beneficial therapeutic
applications.

Methods::
In this study, the C-terminal region of Snail1, capable of binding to E-box genomic sequences,
was subcloned into the pAAV-IRES-EGFP backbone to make complete AAV-CSnail
viral particles. B16F10 as a metastatic melanoma cell line, with a null expression of wild type
TP53 was transduced by AAV-CSnail. Moreover, the transduced cells were analyzed for in vitro
expression of apoptosis, migration, and EMT-related genes, and in vivo inhibition of metastasis.

Results::
In more than 80% of the AAV-CSnail transduced cells, the CSnail gene expression competitively
reduced the wild-type Snail functionality and consequently lowered the mRNA expression
level of EMT-related genes. Furthermore, the transcription level of cell cycle inhibitory factor
p21 and pro-apoptotic factors were promoted. The scratch test showed a decrease in the migration
ability of AAV-CSnail transduced group compared to control. Finally, metastasis of cancer cells to
lung tissue in the AAV-CSnail-treated B16F10 melanoma mouse model was significantly reduced,
pointing out to prevention of EMT by the competitive inhibitory effect of CSnail on Snail1 and
increased apoptosis of B16F10 cells.

Conclusion::
The capability of this successful competition in reducing the growth, invasion, and
metastasis of melanoma cells indicates that gene therapy is a promising strategy for the control of
the growth and metastasis of cancer cells.
Neurological Complications Caused by Human Immunodeficiency Virus (HIV) and Associated Opportunistic Co-infections: A Review on their
Diagnosis and Therapeutic Insights
Authors: Balaji Sivaraman , Chakraborty Rohan , Aggarwal Sumit 
Published: April 2023

Abstract:
Neurocognitive disorders associated with human immunodeficiency virus (HIV) infected
individuals increase the risk of mortality and morbidity that remain a prevalent clinical complication
even in the antiretroviral therapy era. It is estimated that a considerable number of people in the HIV
community are developing neurological complications at their early stages of infection. The daily lives
of people with chronic HIV infections are greatly affected by cognitive declines such as loss of attention,
learning, and executive functions, and other adverse conditions like neuronal injury and dementia.
It has been found that the entry of HIV into the brain and subsequently crossing the blood-brain
barrier (BBB) causes brain cell damage, which is the prerequisite for the development of neurocognitive
disorders. Besides the HIV replication in the central nervous system and the adverse effects of antiretroviral
therapy on the BBB, a range of opportunistic infections, including viral, bacterial, and parasitic
agents, augment the neurological complications in people living with HIV (PLHIV). Given the
immuno-compromised state of PLHIV, these co-infections can present a wide range of clinical syndromes
with atypical manifestations that pose challenges in diagnosis and clinical management, representing
a substantial burden for the public health system. Therefore, the present review narrates the
neurological complications triggered by HIV and their diagnosis and treatment options. Moreover, coinfections
that are known to cause neurological disorders in HIV infected individuals are highlighted.