bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel multi‐modality imaging phantom for validating interstitial needle guidance for high dose rate gynecological brachytherapy
Authors: Eckroate Brett , Ayala‐Peacock Diandra , Venkataraman Rajesh , Campelo Sabrina , Chino Junzo , Stephens Sarah Jo , Kim Yongbok , Meltsner Sheridan , Raffi Julie , Craciunescu Oana 
Published: June 2023

AbstractPurposeTo design, manufacture, and validate a female pelvic phantom for multi‐modality imaging (CT, MRI, US) to benchmark a commercial needle tracking system with application in HDR gynecological (GYN) interstitial procedures.Materials and MethodsA GYN needle‐tracking phantom was designed using CAD software to model an average uterus from a previous patient study, a vaginal canal from speculum dimensions, and a rectum to accommodate a transrectal ultrasound (TRUS) probe. A target volume (CTVHR) was designed as an extension from the cervix‐uterus complex. Negative space molds were created from modeled anatomy and 3D printed. Silicone was used to cast the anatomy molds. A 3D printed box was constructed to house the manufactured anatomy for structural integrity and to accommodate the insertion of a speculum, tandem, needles, and TRUS probe. The phantom was CT‐imaged to identify potential imperfections that might impact US visualization. Free‐hand TRUS was used to guide interstitial needles into the phantom. The commercial tracking system was used to generate a 3D US volume. After insertion, the phantom was imaged with CT and MR and the uterus and CTVHR dimensions were verified against the CAD model.Results/ConclusionsThe manufactured phantom allows for accurate visualization with multiple imaging modalities and is conducive to applicator and needle insertion. The phantom dimensions from the CAD model were verified with those from each imaging modality. The phantom is low cost and can be reproducibly manufactured with the 3D printing and molding processes. Our initial experiments demonstrate the ability to integrate the phantom with a commercial tracking system for future needle tracking validation studies.
Social Determinants of Health Documentation Among Individuals With Rheumatic and Musculoskeletal Conditions in an Integrated Care Management Program
Authors: Ulysse Sciaska N. , Chandler Mia T. , Santacroce Leah , Cai Tianrun , Liao Katherine P. , Feldman Candace H. 
Published: June 2023

ObjectiveSocial determinants of health (SDoH), such as poverty, are associated with increased burden and severity of rheumatic and musculoskeletal diseases. This study was undertaken to study the prevalence and documentation of SDoH‐related needs in electronic health records (EHRs) of individuals with these conditions.MethodsWe randomly selected individuals with ≥1 International Classification of Diseases, Ninth/Tenth Revision (ICD‐9/10) code for a rheumatic/musculoskeletal condition enrolled in a multihospital integrated care management program that coordinates care for medically and/or psychosocially complex individuals. We assessed SDoH documentation using terms for financial needs, food insecurity, housing instability, transportation, and medication access according to EHR note review and ICD‐10 SDoH billing codes (Z codes). We used multivariable logistic regression to examine associations between demographic factors (age, gender, race, ethnicity, insurance) and ≥1 (versus 0) SDoH need as the odds ratio (OR) with 95% confidence interval (95% CI).ResultsAmong 558 individuals with rheumatic/musculoskeletal conditions, 249 (45%) had ≥1 SDoH need documented in EHR notes by social workers, care coordinators, nurses, and physicians. A total of 171 individuals (31%) had financial insecurity, 105 (19%) had transportation needs, 94 (17%) had food insecurity; 5% had ≥1 related Z code. In the multivariable model, the odds of having ≥1 SDoH need was 2.45 times higher (95% CI 1.17–5.11) for Black versus White individuals and significantly higher for Medicaid or Medicare beneficiaries versus commercially insured individuals.ConclusionNearly half of this sample of complex care management patients with rheumatic/musculoskeletal conditions had SDoH documented within EHR notes; financial insecurity was the most prevalent. Only 5% of patients had representative billing codes suggesting that systematic strategies to extract SDoH from notes are needed.
First‐Aid Hydrogel Wound Dressing with Reliable Hemostatic and Antibacterial Capability for Traumatic Injuries
Authors: Cheng Junyao , Wang Hufei , Gao Jianpeng , Liu Xiao , Li Ming , Wu Decheng , Liu Jianheng , Wang Xing , Wang Zheng , Tang Peifu 
Published: June 2023

AbstractFirst‐aid for severe traumatic injuries in the battlefield or pre‐hospital environment, especially for skin defects or visceral rupture, remains a substantial medical challenge even in the context of the rapidly evolving modern medical technology. Hydrogel‐based biomaterials are highly anticipated for excellent biocompatibility and bio‐functional designability. Yet, inadequate mechanical and bio‐adhesion properties limit their clinical application. To address these challenges, a kind of multifunctional hydrogel wound dressing is developed with the collective multi‐crosslinking advantages of dynamic covalent bonds, metal−catechol chelation, and hydrogen bonds. The mussel‐inspired design and zinc oxide‐enhanced cohesion strategy collaboratively reinforce the hydrogel's bio‐adhesion in bloody or humoral environments. The pH‐sensitive coordinate Zn2+‐catechol bond and dynamic Schiff base with reversible breakage and reformation equip the hydrogel dressing with excellent self‐healing and on‐demand removal properties. In vivo evaluation in a rat ventricular perforation model and Methicillin‐resistant Staphylococcus aureus (MRSA)‐infected full‐thickness skin defect model reveal excellent hemostatic, antibacterial and pro‐healing effectiveness of the hydrogel dressing, demonstrating its great potential in dealing with severe bleeding and infected full‐thickness skin wounds.
Protein/Polysaccharide Composite toward Multi‐in‐One Toxin Removal in Blood with Self‐Anticoagulation and Biocompatibility
Authors: Li Mengjie , Chen Mengmeng , Yang Facui , Qin Rongrong , Yang Qingmin , Ren Hao , Liu Han , Yang Peng 
Published: June 2023

AbstractBiocompatible adsorbents play an essential role in hemoperfusion. Nevertheless, there are no hemoperfusion adsorbents that can simultaneously remove small and medium toxins, including bilirubin, urea, phosphor, heavy metals, and antibiotics. This bottleneck significantly impedes the miniaturization and portability of hemoperfusion materials and devices. Herein, a biocompatible protein‐polysaccharide complex is reported that exhibits “multi‐in‐one” removal efficacy for liver and kidney metabolism wastes, toxic metal ions, and antibiotics. Through electrostatic interactions and polysaccharide‐mediated coacervation, adsorbents can be prepared by simply mixing lysozyme (LZ) and sodium alginate (SA) together in seconds. The LZ/SA absorbent presented high adsorption capacities for bilirubin, urea, and Hg2+ of up to 468, 331, and 497 mg g−1, respectively, and the excellent anti‐protein adsorption endowed LZ/SA with a record‐high adsorption capacity for bilirubin in the interference of serum albumin to simulate the physiological environment. The LZ/SA adsorbent also has effective adsorption capacity for heavy metals (Pb2+, Cu2+, Cr3+, and Cd2+) and multiple antibiotics (terramycin, tetracycline, enrofloxacin, norfloxacin, roxithromycin, erythromycin, sulfapyrimidine, and sulfamethoxazole). Various adsorption functional groups exposed on the adsorbent surface significantly contribute to the excellent adsorption capacity. This fully bio‐derived protein/alginate‐based hemoperfusion adsorbent has great application prospects in the treatment of blood‐related diseases.
Phonon Polaritonics in Broad Terahertz Frequency Range with Quantum Paraelectric SrTiO3
Authors: Xu Rui , Lin Tong , Luo Jiaming , Chen Xiaotong , Blackert Elizabeth R. , Moon Alyssa R. , JeBailey Khalil M. , Zhu Hanyu 
Published: June 2023

AbstractPhotonics in the frequency range of 5–15 terahertz (THz) potentially open a new realm of quantum materials manipulation and biosensing. This range, sometimes called “the new terahertz gap”, is traditionally difficult to access due to prevalent phonon absorption bands in solids. Low‐loss phonon–polariton materials may realize sub‐wavelength, on‐chip photonic devices, but typically operate in mid‐infrared frequencies with narrow bandwidths and are difficult to manufacture on a large scale. Here, for the first time, quantum paraelectric SrTiO3 enables broadband surface phonon–polaritonic devices in 7–13 THz. As a proof of concept, polarization‐independent field concentrators are designed and fabricated to locally enhance intense, multicycle THz pulses by a factor of 6 and increase the spectral intensity by over 90 times. The time‐resolved electric field inside the concentrators is experimentally measured by THz‐field‐induced second harmonic generation. Illuminated by a table‐top light source, the average field reaches 0.5 GV m−1 over a large volume resolvable by far‐field optics. These results potentially enable scalable THz photonics with high breakdown fields made of various commercially available phonon–polariton crystals for studying driven phases in quantum materials and nonlinear molecular spectroscopy.
High‐Resolution, Highly Transparent, and Efficient Quantum Dot Light‐Emitting Diodes
Authors: Luo Chengzhao , Zheng Zhishuai , Ding Yanhui , Ren Zhenwei , Shi Hengfei , Ji Huifeng , Zhou Xin , Chen Yu 
Published: June 2023

AbstractAiming at next‐generation displays, high‐resolution quantum dot light‐emitting diodes (QLEDs) with high efficiency and transparency are highly desired. However, there is limited study involving the improvements of QLED pixel resolution, efficiency, and transparency simultaneously, which undoubtedly restricts the practical applications of QLED for next‐generation displays. Here, the strategy of electrostatic force‐induced deposition (EF‐ID) is proposed by introducing alternating polyethyleneimine (PEI) and fluorosilane patterns to synergistically improve the pixel accuracy and transmittance of QD patterns. More importantly, the leakage current induced by the void spaces between pixels that is usually reported for high‐resolution QLEDs is greatly suppressed by substrate‐assisted insulating fluorosilane patterns. Finally, high‐performance QLEDs with high resolution ranging from 1104 to 3031 pixels per inch (PPI) and a high efficiency of 15.6% are achieved, among the best performances of high resolution QLEDs. Notably, the high resolution QD pixels greatly enhance the transmittance of the QD patterns, thus prompting an impressive transmittance of 90.7% for the transparent QLEDs (2116 PPI), which represents the highest transmittance of transparent QLED devices. Consequently, this work contributes an effective and general approach for high‐resolution QLEDs with high efficiency and transparency.
Real‐world effectiveness of intensive chemotherapy with 7&3 versus venetoclax and hypomethylating agent in acute myeloid leukemia
Authors: Matthews Andrew H. , Perl Alexander E. , Luger Selina M. , Gill Saar I. , Lai Catherine , Porter David L. , Skuli Sarah , Bruno Ximena Jordan , Carroll Martin P. , Freyer Craig W. , Carulli Alison , Babushok Daria V. , Frey Noelle V. , Hexner Elizabeth O. , Martin Mary Ellen , McCurdy Shannon R. , Stadtmauer Edward A. , Loren Alison W. , Paralkar Vikram R. , Maillard Ivan P. , Pratz Keith W. 
Published: June 2023

AbstractIntensive chemotherapy with cytarabine and anthracycline (7&3) remains the standard therapy for patients medically fit for induction, but the assessment of fitness remains controversial. Venetoclax and hypomethylating agent (ven/HMA) combination therapy has improved outcomes in unfit patients but no prospective study has assessed ven/HMA versus 7&3 as initial therapy in older, fit patients. Given no studies and expectation of ven/HMA use in patients outside of trial criteria, we evaluated retrospective outcomes among newly diagnosed patients. A nationwide electronic health record (EHR)‐derived database and the University of Pennsylvania EHR identified 312 patients receiving 7&3 and 488 receiving ven/HMA who were 60–75 years old without history of organ failure. Ven/HMA patients were older and more likely to have secondary AML, adverse cytogenetics, and adverse mutations. Median overall survival (OS) for patients receiving intensive chemotherapy was 22 versus 10 months for ven/HMA (HR 0.53, 95% CI 0.40–0.60). Controlling for measured baseline characteristic imbalances reduced survival advantage by half (HR 0.71, 95% CI 0.53–0.94). A sub‐group of patients with equipoise, likelihood at least 30%–70% of receiving either treatment, had similar OS outcomes (HR 1.10, 95% CI 0.75–1.6). Regarding safety outcomes, 60‐day mortality was higher for ven/HMA (15% vs. 6% at 60 days) despite higher documented infections and febrile neutropenia for 7&3. In this multicenter real‐word dataset, patients selected for intensive chemotherapy had superior OS but a large group had similar outcomes with ven/HMA. Prospective randomized studies, controlling for both measured and unmeasured confounders, must confirm this outcome.
Evolving trends and outcomes in older patients with acute myeloid leukemia including allogeneic stem cell transplantation
Authors: Bazinet Alexandre , Kantarjian Hagop , Arani Naszrin , Popat Uday , Bataller Alex , Sasaki Koji , DiNardo Courtney D. , Daver Naval , Yilmaz Musa , Abbas Hussein A. , Short Nicholas J. , Issa Ghayas , Jabbour Elias , Pierce Sherry A. , Chen Julianne , Garcia Ricky , Konopleva Marina , Garcia‐Manero Guillermo , Alousi Amin , Shpall Elizabeth J. , Champlin Richard E. , Borthakur Gautam , Ravandi Farhad , Kadia Tapan 
Published: June 2023

AbstractOutcomes in older patients with acute myeloid leukemia (AML) have historically been poor. Given advances in low‐intensity therapy (LIT) and stem cell transplantation (SCT), we performed a retrospective single‐center study to evaluate the contemporary outcomes of this population. We reviewed all patients ≥60 years with newly diagnosed AML between 2012 and 2021 and analyzed treatment and SCT‐related trends and outcomes. We identified 1073 patients with a median age of 71 years. Adverse clinical and cytomolecular findings were frequent within this cohort. In total, 16% of patients were treated with intensive chemotherapy, 51% with LIT alone, and 32% with LIT plus venetoclax. The composite complete remission rate with LIT plus venetoclax was 72%, which was higher than with LIT alone (48%, p < .0001) and comparable to intensive chemotherapy (74%, p = .6). The median overall survival (OS) with intensive chemotherapy, LIT, and LIT plus venetoclax was 20.1, 8.9, and 12.1 months, respectively. 18% of patients received SCT. SCT rates were 37%, 10%, and 22% in patients treated with intensive chemotherapy, LIT, and LIT plus venetoclax, respectively. The 2‐year OS, relapse‐free survival (RFS), cumulative incidence (CI) of relapse, and CI of treatment‐related mortality with frontline SCT (n = 139) were 59%, 52%, 27%, and 22%, respectively. By landmark analysis, patients undergoing frontline SCT had superior OS (median 39.6 vs. 21.4 months, p < .0001) and RFS (30.9 vs. 12.1 months, p < .0001) compared with responding patients who did not. Outcomes in older patients with AML are improving with more effective LIT. Measures should be pursued to increase access to SCT in older patients.
Click‐Chemistry‐Enabled Nanopipettes for the Capture and Dynamic Analysis of a Single Mitochondrion inside One Living Cell
Authors: Liu Kang , Zhang Zheng , Liu Rujia , Li Jie P. , Jiang Dechen , Pan Rongrong 
Published: June 2023

AbstractThe in‐depth study of single cells requires the dynamically molecular information in one particular nanometer‐sized organelle in a living cell, which is difficult to achieve using current methods. Due to high efficiency of click chemistry, a new nanoelectrode‐based pipette architecture with dibenzocyclooctyne at the tip is designed to realize fast conjugation with azide group‐containing triphenylphosphine, which targets mitochondrial membranes. The covalent binding of one mitochondrion at the tip of the nanopipette allows a small region of the membrane to be isolated on the Pt surface inside the nanopipette. Therefore, the release of reactive oxygen species (ROS) from the mitochondrion is monitored, which is not interfered by the species present in the cytosol. The dynamic tracking of ROS release from one mitochondrion reveals the distinctive “ROS‐induced ROS release” within the mitochondria. Further study of RSL3‐induced ferroptosis using nanopipettes provides direct evidence for supporting the noninvolvement of glutathione peroxidase 4 in the mitochondria during RSL3‐induced ROS generation, which has not previously been observed at the single‐mitochondrion level. Eventually, this established strategy should overcome the existing challenge of the dynamic measurement of one special organelle in the complicated intracellular environment, which opens a new direction for electroanalysis in subcellular analysis.
Copper‐Phosphido Catalysis: Enantioselective Addition of Phosphines to Cyclopropenes**
Authors: Daniels Brian S. , Hou Xintong , Corio Stephanie A. , Weissman Lindsey M. , Dong Vy M. , Hirschi Jennifer S. , Nie Shaozhen 
Published: June 2023

AbstractWe describe a copper catalyst that promotes the addition of phosphines to cyclopropenes at ambient temperature. A range of cyclopropylphosphines bearing different steric and electronic properties can now be accessed in high yields and enantioselectivities. Enrichment of phosphorus stereocenters is also demonstrated via a Dynamic Kinetic Asymmetric Transformation (DyKAT) process. A combined experimental and theoretical mechanistic study supports an elementary step featuring insertion of a CuI‐phosphido into a carbon‐carbon double bond. Density functional theory calculations reveal migratory insertion as the rate‐ and stereo‐determining step, followed by a syn‐protodemetalation.
Beobachtung der ersten Schlüsselschritte eines titanbasierten Photoredox‐Katalysezyklus in Echtzeit
Authors: Schmidt Jonas , Domenianni Luis I. , Leuschner Marcel , Gansäuer Andreas , Vöhringer Peter 
Published: June 2023

AbstractDie titanbasierte Katalyse mit Ein‐Elektronentransfer‐Schritten (SET) hat sich zu einem vielseitigen Ansatz für die Synthese von Feinchemikalien entwickelt. Kürzlich wurden erste Versuche unternommen, ihre Nachhaltigkeit zu verbessern, indem sie mit der Photoredox (PR) Katalyse kombiniert wird. Hier untersuchen wir die photochemischen Prinzipien der SET‐PR‐Katalyse auf Basis von Ti und in Abwesenheit eines Edelmetall PR−Co‐Katalysators. Durch Kombination von zeitaufgelöster Emissionsspektroskopie mit Ultraviolett‐Anregungs‐/Infrarot‐Abfrage‐Spektroskopie auf Zeitskalen von Femtosekunden bis Mikrosekunden quantifizieren wir die Dynamik der kritischen Ereignisse bei der Initiierung des Katalysezyklus, nämlich die Singulett‐Triplett‐Umwandlung des Titanocen(IV) PR‐Universalkatalysators und seine Ein‐Elektronen‐Reduktion durch einen Amin‐Elektronendonator. Die Ergebnisse unterstreichen die Bedeutung der Singulett‐Triplett‐Energielücke des PR‐Katalysators als Leitfaden für künftige Verbesserungen.
Bottom‐up Solution Synthesis of Graphene Nanoribbons with Precisely Engineered Nanopores
Authors: Niu Wenhui , Fu Yubin , Serra Gianluca , Liu Kun , Droste Jörn , Lee Yeonju , Ling Zhitian , Xu Fugui , Cojal González José D. , Lucotti Andrea , Rabe Jürgen P. , Ryan Hansen Michael , Pisula Wojciech , Blom Paul W. M. , Palma Carlos‐Andres , Tommasini Matteo , Mai Yiyong , Ma Ji , Feng Xinliang 
Published: June 2023

AbstractThe incorporation of nanopores into graphene nanostructures has been demonstrated as an efficient tool in tuning their band gaps and electronic structures. However, precisely embedding the uniform nanopores into graphene nanoribbons (GNRs) at the atomic level remains underdeveloped especially for in‐solution synthesis due to the lack of efficient synthetic strategies. Herein we report the first case of solution‐synthesized porous GNR (pGNR) with a fully conjugated backbone via the efficient Scholl reaction of tailor‐made polyphenylene precursor (P1) bearing pre‐installed hexagonal nanopores. The resultant pGNR features periodic subnanometer pores with a uniform diameter of 0.6 nm and an adjacent‐pores‐distance of 1.7 nm. To solidify our design strategy, two porous model compounds (1 a, 1 b) containing the same pore size as the shortcuts of pGNR, are successfully synthesized. The chemical structure and photophysical properties of pGNR are investigated by various spectroscopic analyses. Notably, the embedded periodic nanopores largely reduce the π‐conjugation degree and alleviate the inter‐ribbon π–π interactions, compared to the nonporous GNRs with similar widths, affording pGNR with a notably enlarged band gap and enhanced liquid‐phase processability.
An Artificial Intelligence Approach for Tackling Conformational Energy Uncertainties in Chiroptical Spectroscopies
Authors: Marton Gabriel , Koenis Mark A. J. , Liu Hong‐Bing , Bewley Carole A. , Buma Wybren Jan , Nicu Valentin Paul 
Published: June 2023

AbstractDetermination of the absolute configuration of chiral molecules is a prerequisite for obtaining a fundamental understanding in any chirality‐related field. The interaction with polarised light has proven to be a powerful means to determine this absolute configuration, but its application rests on the comparison between experimental and computed spectra for which the inherent uncertainty in conformational Boltzmann factors has proven to be extremely hard to tackle. Here we present a novel approach that overcomes this issue by combining a genetic algorithm that identifies the relevant conformers by accounting for the uncertainties in DFT relative energies, and a hierarchical clustering algorithm that analyses the trends in the spectra of the considered conformers and identifies on‐the‐fly when a given chiroptical technique is not able to make reliable predictions. The effectiveness of this approach is demonstrated by considering the challenging cases of papuamine and haliclonadiamine, two bis‐indane natural products with eight chiral centres and considerable conformational heterogeneity that could not be assigned unambiguously with current approaches.
Investigating the Influence of the Effective Ionic Transport on the Electrochemical Performance of Si/C‐Argyrodite Solid‐State Composites
Authors: Rudel Yannik , Rana Moumita , Ruhl Justine , Rosenbach Carolin , Müller Jannes , Michalowski Peter , Kwade Arno , Zeier Wolfgang G. 
Published: June 2023

AbstractSolid‐state batteries have the potential to outperform conventional lithium‐ion batteries, as they offer higher energy densities, necessary for the increasing demand for portable energy storage. Silicon‐graphite composites are considered to be one of the most promising alternatives to the lithium metal anode due to their low lithiation potential and resistance against dendrite formation. Since these composites show insufficient ionic conductivity, a fast‐conducting solid electrolyte is needed to facilitate the charge carrier transport. Optimizing the volume fractions of the solid electrolyte is crucial to ensure sufficient charge carrier transport and achieve the optimal performance. In this work, the influence of the charge carrier transport in a silicon on graphite (Si/C)/argyrodite solid electrolyte composite on the electrochemical performance is studied. By systematically varying the ratio of the Si/C to solid electrolyte, it was found that the effective ionic conductivity of the electrode composite improves exponentially with increasing content of the solid electrolyte, which in turn leads to an increase in the specific capacity of the composite across all C‐rates. This study highlights the importance of understanding and customizing charge carrier transport properties in solid‐state anode composites to achieve optimum electrochemical performance.