bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-disgust in patients with borderline personality disorder. The associations with alexithymia, emotion dysregulation, and comorbid psychopathology
Authors: Kot Emilia , Kostecka Barbara , Radoszewska Joanna , Kucharska Katarzyna 
Published: August 2023

Abstract
Background
Self-disgust is a negative self-conscious emotion, which has been linked with borderline personality disorder (BPD). However, it has not yet been investigated in relation to both emotion dysregulation and alexithymia, which are recognized as crucial to BPD. Therefore, the aim of our study was to measure these variables and examine the possible mediational role of emotional alterations and comorbid anxiety and depression symptoms in shaping self-disgust in patients with BPD and healthy controls (HCs).

Methods
In total, the study included 100 inpatients with BPD and 104 HCs. Participants completed: the Self-Disgust Scale (SDS), Disgust Scale – Revised (DS-R), Toronto Alexithymia Scale (TAS-20), Emotion Dysregulation Scale short version (EDS-short), Borderline Personality Disorder Checklist (BPD Checklist), State-Trait Anxiety Inventory (STAI), and Center for Epidemiologic Studies Depression Scale (CESD-R).

Results
Inpatients with BPD showed higher self-disgust, alexithymia, emotion dysregulation, core and comorbid symptoms levels, and lower disgust sensitivity. Alexithymia, emotion dysregulation, and trait anxiety partially mediated between BPD diagnosis and self-disgust. The relationship between the severity of BPD symptoms and self-disgust was fully mediated by alexithymia, emotion dysregulation, depressive symptoms, and trait anxiety.

Conclusions
The results of our study may imply the contribution of emotion dysregulation, alexithymia, and comorbid psychopathology to self-referenced disgust in BPD.
Artificial intelligence in intelligent tutoring systems toward sustainable education: a systematic review
Authors: Lin Chien-Chang , Huang Anna Y. Q. , Lu Owen H. T. 
Published: August 2023

AbstractSustainable education is a crucial aspect of creating a sustainable future, yet it faces several key challenges, including inadequate infrastructure, limited resources, and a lack of awareness and engagement. Artificial intelligence (AI) has the potential to address these challenges and enhance sustainable education by improving access to quality education, creating personalized learning experiences, and supporting data-driven decision-making. One outcome of using AI and Information Technology (IT) systems in sustainable education is the ability to provide students with personalized learning experiences that cater to their unique learning styles and preferences. Additionally, AI systems can provide teachers with data-driven insights into student performance, emotions, and engagement levels, enabling them to tailor their teaching methods and approaches or provide assistance or intervention accordingly. However, the use of AI and IT systems in sustainable education also presents challenges, including issues related to privacy and data security, as well as potential biases in algorithms and machine learning models. Moreover, the deployment of these systems requires significant investments in technology and infrastructure, which can be a challenge for educators. In this review paper, we will provide different perspectives from educators and information technology solution architects to connect education and AI technology. The discussion areas include sustainable education concepts and challenges, technology coverage and outcomes, as well as future research directions. By addressing these challenges and pursuing further research, we can unlock the full potential of these technologies and support a more equitable and sustainable education system.
Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells
Authors: Wang Xin , Zhang Yongtao , Wang Dongdong , Su Ning , Yang Li , Fu Hao , Zhang Jiachan , Li Meng , Wang Changtao 
Published: August 2023

Abstract
Background
Aureobasidium pullulans (A. pullulans) has a wide range of applications. Ultraviolet (UV) rays from the sun can cause skin photoaging. In order to explore the protective effect and application potential of A. pullulans lysate on UV-damaged human skin fibroblasts (HSF) and HaCaT Cells, this study investigates the anti-aging and anti-inflammatory effects of A. pullulans lysate as well as the mechanism of anti-oxidative stress at the cellular and molecular levels through cytotoxicity experiments, enzyme-linked immunosorbent assays (ELISA), and real-time quantitative PCR (RT-qPCR).

Results
The experimental results have shown that the A. pullulans lysate can effectively reduce the loss of extracellular matrix components (EMC), such as collagen and hyaluronic acid (HA). It is also capable of scavenging excess reactive oxygen species (ROS) from the body, thereby increasing the activity of catalase, decreasing the overexpression of intracellular matrix metalloproteinases (MMPs), enhancing the gene expression of metalloproteinase inhibitors (TIMPs), and decreasing the level of inflammatory factors, reducing UV-induced apoptosis of HaCaT cells. Meanwhile, oxidative stress homeostasis is also regulated through the Nrf2/Keap1 and MAPK signaling pathways.

Conclusions
This study shows that the A. pullulans lysate has the potential to resist photoaging.

Graphical Abstract
Acute peritonitis caused by the acute pancreatitis of an ectopic pancreas in a jejunal duplication, in an adult with intestinal malrotation: a case report
Authors: Yoshikawa Chihiro , Migita Kazuhiro , Yamato Ichiro , Ueno Masato , Kashizuka Hisanori , Murakami Koichi , Ishikawa Hirofumi 
Published: August 2023

Abstract
Background
Intestinal duplication and ectopic pancreas are two rare independent congenital anomalies. Few reports describe cases of patients with ectopic pancreas in an intestinal duplication causing acute peritonitis.

Case presentation
A 31-year-old man was admitted to the hospital for epigastric pain. The patient was diagnosed with acute peritonitis caused by the acute pancreatitis of an ectopic pancreas in a jejunal duplication, with intestinal malrotation. The patient underwent the partial resection of the jejunum and Ladd’s procedure. The histopathological findings indicated ectopic pancreatitis in the jejunal duplication.

Conclusions
We presented the case of acute peritonitis caused by the acute pancreatitis of an ectopic pancreas in a jejunal duplication in an adult with intestinal malrotation. Surgery is the primary treatment and is necessary for a definitive diagnosis.
Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment
Authors: Lee Eun Sook , Ko Hyewon , Kim Chan Ho , Kim Hyun-Chul , Choi Seong-Kyoon , Jeong Sang Won , Lee Se-Guen , Lee Sung-Jun , Na Hee-Kyung , Park Jae Hyung , Shin Jung Min 
Published: August 2023

Abstract

Background
Exosomes are extracellular vesicles secreted by eukaryotic cells and have been extensively studied for their surface markers and internal cargo with unique functions. A deeper understanding of exosomes has allowed their application in various research areas, particularly in diagnostics and therapy.

Main body
Exosomes have great potential as biomarkers and delivery vehicles for encapsulating therapeutic cargo. However, the limitations of bare exosomes, such as rapid phagocytic clearance and non-specific biodistribution after injection, pose significant challenges to their application as drug delivery systems. This review focuses on exosome-based drug delivery for treating rheumatoid arthritis, emphasizing pre/post-engineering approaches to overcome these challenges.

Conclusion
This review will serve as an essential resource for future studies to develop novel exosome-based therapeutic approaches for rheumatoid arthritis. Overall, the review highlights the potential of exosomes as a promising therapeutic approach for rheumatoid arthritis treatment.

Graphical Abstract
Diversified caregiver input to upgrade the Young Children’s Participation and Environment Measure for equitable pediatric re/habilitation practice
Authors: Villegas Vivian C. , Bosak Dianna L. , Salgado Zurisadai , Phoenix Michelle , Parde Natalie , Teplicky Rachel , Khetani Mary A. ,   High Value Early Intervention Research Group, Kuznicki L. , Pedrow A. , Howell A. 
Published: August 2023

Abstract
Background
Practitioner and family experiences of pediatric re/habilitation can be inequitable. The Young Children’s Participation and Environment Measure (YC-PEM) is an evidence-based and promising electronic patient-reported outcome measure that was designed with and for caregivers for research and practice. This study examined historically minoritized caregivers’ responses to revised YC-PEM content modifications and their perspectives on core intelligent virtual agent functionality needed to improve its reach for equitable service design.

Methods
Caregivers were recruited during a routine early intervention (EI) service visit and met five inclusion criteria: (1) were 18 + years old; (2) identified as the parent or legal guardian of a child 0–3 years old enrolled in EI services for 3 + months; (3) read, wrote, and spoke English; (4) had Internet and telephone access; and (5) identified as a parent or legal guardian of a Black, non-Hispanic child or as publicly insured. Three rounds of semi-structured cognitive interviews (55–90 min each) used videoconferencing to gather caregiver feedback on their responses to select content modifications while completing YC-PEM, and their ideas for core intelligent virtual agent functionality. Interviews were transcribed verbatim, cross-checked for accuracy, and deductively and inductively content analyzed by multiple staff in three rounds.

Results
Eight Black, non-Hispanic caregivers from a single urban EI catchment and with diverse income levels (Mdn = $15,001–20,000) were enrolled, with children (M = 21.2 months, SD = 7.73) enrolled in EI. Caregivers proposed three ways to improve comprehension (clarify item wording, remove or simplify terms, add item examples). Environmental item edits prompted caregivers to share how they relate and respond to experiences with interpersonal and institutional discrimination impacting participation. Caregivers characterized three core functions of a virtual agent to strengthen YC-PEM navigation (read question aloud, visual and verbal prompts, more examples and/or definitions).

Conclusions
Results indicate four ways that YC-PEM content will be modified to strengthen how providers screen for unmet participation needs and determinants to design pediatric re/habilitation services that are responsive to family priorities. Results also motivate the need for user-centered design of an intelligent virtual agent to strengthen user navigation, prior to undertaking a community-based pragmatic trial of its implementation for equitable practice.
Novel composite membrane based on recycled low-density polyethylene-alumina used for vacuum membrane distillation
Authors: Hanen Ajari , Fatma Khaled , Hiba Akrout , Khaoula Hidouri , Béchir Chaouachi , Qusay Alsalhy 
Published: August 2023

AbstractBackgroundPlastic materials have a significant impact on the entire environment. Very relevant ideas in different areas with the aim of enhancing these materials and making them effective in our daily lives. In this context, our work in this article by using plastic materials in the manufacture of hydrophobic membranes realized in our Laboratory LEEP Enig Gabes Tunisia, followed by various analyses. These membranes are made of a Recycled Low-Density Polyethylene polymer by means of the Thermal Induced Phase Separation (TIPS) method by using solvents such as Butyl Acetate, non-solvent Hexane with the addition of Alumina at different concentrations to increase porosity.ResultsHydrophobic membranes are coupled to the vacuum still to test their performance. An analytical study by FTIR was done. Contact angle, pore size, porosity, mechanical test, bubble point pressure, AFM and SEM analysis. The results revealed that the addition of alumina had an important role in improving the structure, properties and therefore the performance of the membrane.ConclusionsThe membrane already prepared admits according to the analyzes tested a good porosity, hydrophobicity.
Is triple antithrombotic therapy a safe option in patients with AF who receive drug-eluting stents?: a review article
Authors: Alshahrani Ali , O’Nunain Sean 
Published: August 2023

Abstract
Background
Optimal antithrombotic therapy depicts a challenge to clinicians treating atrial fibrillation (AF) patients who are undergoing percutaneous coronary intervention (PCI). Theoretically, these patients would require a combination therapy of oral anticoagulant and dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor, known as triple antithrombotic therapy (TAT). However, TAT is known to carry a significant risk of bleeding. The purpose of the present paper is to provide a focused review of the evidence about the safety of TAT as well as to address contemporary directions regarding antithrombotic therapy following PCI in patients with AF who received a drug-eluting stent.

Main body
Novel oral anticoagulant studies consistently demonstrated a better safety profile when compared to Vitamin K antagonist (warfarin), especially in AF patients who have other indications of DAPT after PCI. Evidence from several studies showed that the use of TAT in AF patients undergoing stent implantation or PCI has no significant clinical benefit with more risk of major bleeding when compared to DAT. Therefore, the current recommendations for AF have taken into account the mounting evidence of antithrombotic treatment after PCI in AF patients, which has caused a major shift away from the TAT strategy toward DAT over time.

Conclusions
Cardiologists face challenges in determining the best antithrombotic treatment for AF patients after PCI with DES implantation. Growing data suggest that TAT is associated with considerable bleeding and worse safety, without significant effectiveness. Hence, TAT is strictly applied for individuals with significant thrombotic risk and low bleeding risk, and for a limited duration. This paper highlights the safety concerns of TAT and current trends in antithrombotic therapy after PCI in patients with AF and DES.
Cross-platform comparison of precision and time effectiveness of automated versus semi-automated brain volumetric measurements in healthy Egyptian adults
Authors: Hassan Abdallah Adel Abdallah , Azab Amr Osama , Ahmed Habeba Mostafa , Mohamed Lena Mohamed Abdel Monem , Adel Mohamed , El-Basmy Ayman A. 
Published: August 2023

Abstract
Background
The primary goal of this study is to evaluate the precision, time effectiveness and reproducibility of open source automated magnetic resonance imaging (MRI) brain volumetric measurement platforms as compared to the semi-automated methods. The secondary goal of the study is to create age-stratified database of MRI brain volumetric measures of healthy Egyptian adults.

Results
Statistically significant variation were found between the absolute but not the relative volumetric measures (P-value < 0.001). Both the absolute and relative global volumetric measures were strongly correlated with age. Only the absolute volumes showed strong correlation with gender with male volumes being significantly higher than females (P-value < 0.0001), while the normative ratio correlation with gender varied with the utilized software.

Conclusions
FMRIB's software library automated segmentation tool (FSL-FAST) was considered the most efficient program to run global volumetric analysis, unless concurrent advanced volumetric analysis is needed or gray matter volume is the main objective of the volumetric analysis, then FreeSurfer is considered the most efficient volumetric software.
Confocal nonlinear optical imaging on hexagonal boron nitride nanosheets
Authors: Lee Gwanjin , Jyothsna Konkada Manattayil , Park Jonghoo , Lee JaeDong , Raghunathan Varun , Kim Hyunmin 
Published: August 2023

AbstractOptical microscopy with optimal axial resolution is critical for precise visualization of two-dimensional flat-top structures. Here, we present sub-diffraction-limited ultrafast imaging of hexagonal boron nitride (hBN) nanosheets using a confocal focus-engineered coherent anti-Stokes Raman scattering (cFE-CARS) microscopic system. By incorporating a pinhole with a diameter of approximately 30 μm, we effectively minimized the intensity of side lobes induced by circular partial pi-phase shift in the wavefront (diameter, d0) of the probe beam, as well as nonresonant background CARS intensities. Using axial-resolution-improved cFE-CARS (acFE-CARS), the achieved axial resolution is 350 nm, exhibiting a 4.3-folded increase in the signal-to-noise ratio compared to the previous case with 0.58 d0 phase mask. This improvement can be accomplished by using a phase mask of 0.24 d0. Additionally, we employed nondegenerate phase matching with three temporally separable incident beams, which facilitated cross-sectional visualization of highly-sample-specific and vibration-sensitive signals in a pump-probe fashion with subpicosecond time resolution. Our observations reveal time-dependent CARS dephasing in hBN nanosheets, induced by Raman-free induction decay (0.66 ps) in the 1373 cm−1 mode.
Gymnema sylvestre as a potential therapeutic agent for PCOS: insights from mRNA differential gene expression and molecular docking analysis
Authors: Vora Divya , Kapadia Hardi , Dinesh Susha , Sharma Sameer , Manjegowda Dinesh Sosalagere 
Published: August 2023

Abstract
Background
In spite of the increased prevalence of Polycystic Ovary Syndrome in bilateral ovaries (PCOS) in females globally (~ 20%), the rate of decisive treatment is limited due to late and invasive diagnostics and the unavailability of stand-alone drugs against phenotypic symptoms associated with PCOS. This study aims at unravelling molecular mechanisms allied with this disorder and identifying genes and pathways that are altered causing PCOS as a pre-requisite need. Furthermore, this study intends at assessing the therapeutic potentials of Gymnemasylvestre phytocompounds mainly triterpene saponins against targeted proteins and helps in seeking exemplar drug candidates. The study is designed in 2 major parts—firstly identifying key proteins involved in pathophysiology by tracing back the deregulated genes in mRNA expression profiles of PCOS Patients obtained from GEO datasets database further compared and analysed by GEO2R Analyzer and significantly deregulated genes were subjected to PPI network, KEGG and GO analysis using STRING and ShinyGO tools. The second half of the study involved molecular docking its visualisation and in silico pharmacological analysis of imminent phytocompounds revealing plausible drug candidates.

Results
In the study, most implied deregulated genes were MRP gene family, ICT1, NDUFA12, VDAC3, APOO, TOMM5, COX6C, COX7B, EDN1 and EDN3 genes whose functional enrichment suggests flawed metabolism of proteins and damaged mitochondrial translation. With high binding affinity, less toxicity at higher dose level Lupeol, Beta-Amyrin, Beta-Elemene, Stigmasterol, Gymnestrogenin and Dammarane proves to be efficient drug candidates.

Conclusion
The findings of this study imply better understanding of the molecular mechanism of the disorder and encourage further clinical studies pertaining to medicinal natural phytocompounds of Gymnemasylvestre.
Is endoscopic septoplasty effective in all types of septal deviations? An observational study on subjective and objective assessment of nasal airway
Authors: Haque Misbahul , Kar Titas , Mukherjee Diptanshu 
Published: August 2023

Abstract
Background
Endoscopic septoplasty has become the preferred choice for septal surgeries for most surgeons due to its precise manipulation and reduced wear and tear. However, the improvement of the airway may vary depending upon the type of septal deviation the patient presents with. Cottle in 1946 stated that just mere dealing with deviated septum alone would not ensure a good functional outcome and he further emphasized on addressing portions of the nose obstructing nasal airflow during surgery. The purpose of our study is to subjectively and objectively assess the effectiveness and corrective extent of endoscopic septal correction in different types of septal deviations (Mladina classification) using NOSE scores and Peak Nasal Inspiratory Flowmetry (PNIF). A prospective cross-sectional study was conducted in 87 patients presented in our department from July 2021 to June 2022 for endoscopic septoplasty.

Results
Post-surgery 1-month follow-up (N1), the correction in terms of NOSE scores was highest in Mladina IV and least in Mladina I deviations, and at the end of 3 months (N2), the correction was best recorded in Mladina VI deviations while the least remained in Mladina I. Similarly, PNIF 1-month follow-up (P1) result had the best correction in the Mladina IV and V groups with the least in Mladina I. 3 months of follow-up (P2) ended up showing a maximum improvement in the Mladina VI group. Paired t test values for improvement of NOSE and PNIF scores were significant (p value < 0.001) between preoperative, 1-month, and 3-month follow-up values and also for repeated measure ANOVA.

Conclusion
Our study reveals that the corrective power of endoscopic septoplasty differs with respect to different types of septal deviation in terms of nasal airflow, both subjectively and objectively. Thus, proper counseling and preoperative assessment is essential for better postoperative outcome and compliance.
Electron irradiation: From test to material tailoring
Authors: Alessi A. , Cavani O. , Grasset R. , Drouhin H.-J. , Safarov V. I. , Konczykowski M. 
Published: August 2023

Abstract
In this article, we report some examples of how high-energy electron irradiation can be used as a tool for shaping material properties turning the generation of point-defects into an advantage beyond the presumed degradation of the properties. Such an approach is radically different from what often occurs when irradiation is used as a test for radiation hard materials or devices degradation in harsh environments. We illustrate the potential of this emerging technique by results obtained on two families of materials, namely semiconductors and superconductors.
Body Image, Maturation, and Psychological Functioning in College Cheerleaders: A Matter of Position?
Authors: Monsma Eva V. , Gay Jennifer L. , Torres-McGehee Toni M. 
Published: August 2023

ABSTRACT
This study examined body image correlates of disordered eating and depression among cheerleaders. Female collegiate cheerleaders (N = 243) completed a battery of surveys, including current and ideal body image related to clothing (i.e., daily clothing, midriff, and full uniform) and meta-perceptions (i.e., perspectives of parents, friends, and coaches). For body image dissatisfaction, all ideal body images were significantly smaller than current body images. Flyers that were significantly shorter and lighter had a lower body mass index and were later maturing, and they reported less dissatisfaction related to daily clothing and from the perspective of parent and friend than bases and back spots. After controlling for body mass index (4%), stepwise regression analyses indicated midriff uniform dissatisfaction (32%), social physique anxiety (6%), and parent meta-perception discrepancy (2%), which predicted disordered eating risk, whereas depression risk was predicted by social physique anxiety (19.1%) and coach meta-perception discrepancy (5.6%). In conclusion, specific focal points for social agents and sport governing bodies are offered with the goal of enhancing recognition, opportunities, and resources for the future of cheerleading.
O Regime Jurídico Especial do Servidor Público
Authors: Rocha João Baptista de Oliveira 
Published: August 2023

1. Colocação do problema. 2. Intenção do emendador de 1969. 3.Competência repartida. 4. Tendência trabalhista. 5. Estados e municípios. 6. Solução de síntese.