bluuebunny/crossref_metadata_2025_split huggingface dataset:
“You mean it's more than just an eating disorder?”: Commentary on Wade et al. (2023)
Authors: Steiger Howard 
Published: September 2023

AbstractDrawing from literature on measurement‐based care and prognostic indices in eating disorder (ED) treatment, Wade et al. offer an algorithm for treating co‐occurring mental‐health conditions (i.e., psychiatric comorbidity) in people with EDs, and for studying effects of comorbidity‐oriented treatments. Advocating session‐by‐session measurement to inform adaptive treatment, their proposal outlines a process for adjusting conventional ED treatment to situations in which comorbidity impedes treatment progress. The plan is methodical and responsive to evidence suggesting that peoples' early in‐treatment change has more power, prognostically, than do indices of comorbidity. In the absence of data to inform practices in some areas, the authors intentionally leave key questions unanswered until future results are in. But this means that they reserve comment on how to determine that comorbidity is interfering with treatment response, or to select the best‐fitting of available comorbidity‐oriented options. Likewise, the proposal draws most of its inspiration from literature on individual (mainly cognitive‐behavioral) psychotherapy and, as a result, does not fully represent biopsychosocial perspectives, or elaborate upon the place in comorbidity management of biological treatments, family, and carer involvement, or more complex integrated approaches. Considerations on how to apply the latter methods would broaden the plan's scope.
Development of an integrated modelling framework to evaluate impacts of pressures on habitat conditions and riverine biota
Authors: Chattopadhyay Somsubhra , Szałkiewicz Ewelina , Dytkiewicz Michał , Marcinkowski Paweł , Mirosław‐Świątek Dorota , Oglęcki Paweł , Piniewski Mikołaj 
Published: September 2023

AbstractIt is becoming extremely challenging to protect the structural and functional integrity of freshwater ecosystems, as many ecological systems face pressures from climate change, population growth and other environmental impacts. However, existing approaches of assessing impacts of external stressors to habitat conditions often neglect the long‐term hydrological changes. This study aimed to develop an integrated modelling framework to assess impacts of different stressors on reach‐scale habitat conditions for benthic macroinvertebrates in a temperate lowland river in central Poland. We coupled hydrological (SWAT+), hydraulic (HEC‐RAS 1D and SRH‐2D) and habitat (CASiMiR) models to predict the response of habitat suitability for the functional group of filter feeders to changes in the catchment for a 135‐m section of the Jeziorka river. Setting up and calibrating individual models required extensive field data collection (e.g., bathymetry field surveys, gauging water levels, discharge and flow velocity measurements and biological sampling). The performance of individual models in simulating discharge, water levels and depth/flow velocity was assessed as satisfactory according to literature. The modelling chain was then applied to compare the effects of three flow scenarios (average, low and high flows). The results showed an overall high value of hydraulic habitat suitability index for filter feeders, with moderately and severely lower values for low and high flow scenario, respectively. The implemented modelling framework performed well could be applied to examine the impacts of climate change and other anthropogenic stressors on reach‐scale habitat conditions. Its practical implementation could be beneficial towards sustainable water resources and environmental flow regime development.
Complexity of hydrology, sewage and industries in distribution and migration pathways of heavy metals at spatial scale of China's brownfields
Authors: Yu Jie‐Yu , Wang Jian‐Jian , Zhang Wei , Kattel Giri R. , Kumar Amit , Yu Zhi‐Guo 
Published: September 2023

AbstractHydrologic dynamics, sewage and industries determine the distribution and migration pathways of heavy metals in the natural environments including soils across the urbanized area. In this study, 323 stratified soil samples from a brownfield in Jiangsu Province, China, were collected to assess the heavy metals (Cu, Ni, Pb, Cd, As and Hg) contaminations. Contamination factor (Cfi), Nemerow pollution index (PIN) and enrichment factor (EFi) were evaluated to assess the heavy metal pollution, while sources of pollution were identified in combination with geo‐statistical, correlations and principal components analysis. Moreover, transport of Ni in soil profiles over the next 30 years was simulated using HYDRUS. The vertical distribution revealed that the soil surface (0–10 cm) had the highest concentration of heavy metal contamination. ICP‐MS measurements showed that the soil in the brownfield was enriched with Cu, Ni, Pb, Cd, As and Hg, where Ni was the most severe and prevalent contaminant. The results of source apportionment analysis showed that Ni, Cd, Pb and Cu were mainly derived from building materials and sewage discharge, while As and Hg may come from fossil fuel combustion and agricultural discharges from upstream river catchment. The migration of Ni was largely driven by the combination of hydrological variability including the flow and solute contaminant gradients in soils. Our work highlights the need for a comprehensive understanding of the complexity of hydrology, and sewage discharge in heavy metal dynamics and migration pathways in China's brownfield soil at regional and national scales.
Three‐Component Reactions of Quinoxalin‐2(1H)‐ones: Recent Advances
Authors: Wang Ke‐Li , Ji Hong‐Tao , Ou Li‐Juan , He Wei‐Min 
Published: September 2023

AbstractThe multicomponent reactions of quinoxalin‐2(1H)‐ones has attracted considerable interest due to their significant biological and chemical activities. The very recent advances (from 2021 to the beginning of 2023) on the radical three‐component cascade reaction of quinoxalin‐2(1H)‐one derivatives at the C3 position were summarized in this mini‐review. According to the kind of radical types involved, some representative examples and detailed reaction mechanism have been categorized and discussed.The red front was covered by Figure 1.
Facile Stereoselective Synthesis and Structural Study of Camphor‐ and Fenchone‐Based Spirocyclic 1,3,4‐Oxadiazolines
Authors: Kovaleva Kseniya S. , Abdrakhmanova Veronika S. , Yarovaya Olga I. , Gatilov Yuriy V. , Rybalova Tatyana V. , Salakhutdinov Nariman F. 
Published: September 2023

AbstractFor the first time, an effective method for the synthesis of spirocyclic camphor‐ and fenchone‐based 1,3,4‐oxadiazolines has been developed. The influence of the molecular structure of the terpene substrate on the reaction stereoselectivity was studied. The structural features of the target products were studied using NMR spectroscopy and X‐ray diffraction analysis. The proposed method allows obtaining of spirocyclic products with a wide structural diversity, stereoselectively and in good yields.
Introducing degummed water‐extracted wild almond oil as a safe vegetable oil through the quality evaluation of par‐fried potato sticks and oil thermo‐oxidative stability during a continuous prolonged deep‐fat frying process
Authors: Nekouei Niloufar , Rezaei Karamatollah 
Published: September 2023

AbstractThe purpose of this study is to evaluate the safety of degummed water‐extracted wild almond oil as a frying medium. Changes in the physicochemical properties of the oil as well as those of the fried potato sticks were evaluated over 10 h of frying at 180°C. Compared to a reference commercial frying oil, free fatty acid content, smoke point, anisidine value, conjugated dienes concentration, total polar compounds, color index, and viscosity did not change significantly during the frying process. French fries prepared during the 10 h of frying in the wild almond oil indicated lower fat levels than those prepared in the commercial frying oil. This can contribute to the well‐being of the consumers as well as to the cost‐efficiency of the process. The color indices are additional quality measures for the fried products that were similar for potatoes fried in both oil sources indicating the safe application of water‐extracted wild almond oil for frying purposes. The application of water‐extracted wild almond oil for frying purposes is found to be a safe process to consider in future frying applications.
Dynamic correlations and volatility spillovers between subsectoral clean‐energy stocks and commodity futures markets: A hedging perspective
Authors: Coskun Merve 
Published: September 2023

AbstractThis study investigates the time‐varying connectedness between subsectoral clean‐energy stocks and fossil fuel energy commodities (crude oil, natural gas, and coal) over the period of December 2013–January 2023 employing the Diebold and Yilmaz approach and the dynamic conditional correlation generalized autoregressive conditional heteroscedasticity model. According to the findings, oil transmits the highest volatility spillover shocks to biofuels, and the least to the fuel cell industry. Both natural gas and coal transmit the highest volatility spillover shocks to energy storage, and the least to geothermal and green information technology, respectively. The study also finds strong and time‐varying volatility connectedness among clean‐energy assets and fossil fuels, significantly affected by global extreme events, such as the COVID‐19 pandemic and the Russia–Ukraine conflict. Additionally, the study provides time‐varying and mean optimal hedge ratios with optimal portfolio weights for investors. The empirical results are robust, and important portfolio and policy implications based on empirical findings are provided.
Long‐term follow‐up of cervical cancer incidence after normal cytological findings
Authors: Wang Jiangrong , Edvardsson Henrik , Strander Björn , Andrae Bengt , Sparén Pär , Dillner Joakim 
Published: September 2023

AbstractAn increase in cervical cancer incidence in Sweden from 2014 to 2015 has been attributed to an increase in false‐negative cytological findings before cancer diagnoses. Years later, we performed a long‐term follow‐up to investigate whether the problem persisted. At each calendar year from 2016 to 2020, we identified women with prior normal cervical screening results through linkage to the Swedish National Cervical Screening Registry. We reported their incidence rates (IRs) of invasive cervical cancer in consecutive years and compared the IRs over time. For the years 2016 to 2020, there was no overall change in cervical cancer incidence after two normal cytology in the last two screening intervals. However, there was a further 62% increase among women 50 to 60 years of age with normal cytology in the past two screening intervals. The incidence rate of cervical cancer was high among nonscreened women and low among HPV‐screened women with negative results, with no trends over time. Our results imply that the previously reported decrease in sensitivity of cervical cytology is persisting. Although primary cytology screening is no longer used, cytology is used in triaging among HPV‐positive women. Our findings suggest that improved triaging is needed, for example, improved quality assurance and/or use of alternative triage tests.
Cushing's syndrome in pregnancy in which laparoscopic adrenalectomy was safely performed by a retroperitoneal approach
Authors: Takeuchi Nobuyoshi , Imamura Yusuke , Ishiwata Kazuki , Kanesaka Manato , Goto Yusuke , Sazuka Tomokazu , Suzuki Sawako , Koide Hisashi , Sakamoto Shinichi , Ichikawa Tomohiko 
Published: September 2023

IntroductionLaparoscopic adrenalectomy is the standard treatment for adrenal tumors caused by Cushing's syndrome. However, few pregnant women have undergone adrenalectomy because of the risk of general anesthesia and surgery.Case presentationA 28‐year‐old woman presented with gradually worsening Cushing's signs at around 12 weeks of pregnancy. Magnetic resonance imaging displayed a 38‐mm left adrenal tumor, which was the cause of the adrenal Cushing's syndrome. Metyrapone was started, which increased androgen levels. Since the management of Cushing's syndrome by medication alone is challenging, unilateral laparoscopic adrenalectomy by a retroperitoneal approach was performed at 23 weeks of the pregnancy. No perioperative complications were noted.ConclusionAdrenalectomy is considered safe in pregnant women with Cushing's syndrome. Laparoscopic adrenalectomy by retroperitoneal approach should be chosen and performed between 14 and 30 weeks of pregnancy to prevent mother and fetal complications.
Does adolescent incivility longitudinally predict future bullying?
Authors: Spadafora Natalie , Volk Anthony A. 
Published: September 2023

AbstractIntroductionAdolescent bullying is a complicated behavior that is difficult to prevent. Understanding factors that predict bullying during adolescence can help us minimize such behavior. Classroom incivility is a low‐level antisocial behavior that has been discussed in the literature as being a potential predictor of bullying in adolescence. Therefore, the goal of the present study was to examine the longitudinal link between classroom incivility and bullying.MethodsData for the current study was collected using quantitative surveys at two‐time points, three years apart (November 2019 and November 2022) in southern Ontario, Canada. Our sample comprised 349 adolescents (51.3% boys, 46.4% girls, 0.6% other, and 1.7% preferred not to say) between the ages of 9 and 14 years old (M = 11.92 years; SD = 1.42). We utilized cross‐lagged analyses to examine the stability of classroom incivility in adolescence, and the longitudinal association between classroom incivility and bullying.ResultsClassroom incivility at Time 1 predicted bullying behavior at Time 2, while bullying at Time 1 did not predict classroom incivility at Time 2. Our results not only support the stability of levels of classroom incivility across time, but also provide empirical support for classroom incivility as a precursor to bullying behavior.ConclusionOur study suggests that classroom incivility can not only negatively impact the learning environment but may also be implicated in contributing to the circumstances that promote bullying behavior in adolescence, highlighting the importance of limiting uncivil behavior before it escalates into more severe forms of behavior.
Clinical Pharmacology Profile of AMG 119, the First Chimeric Antigen Receptor T (CAR‐T) Cell Therapy Targeting Delta‐Like Ligand 3 (DLL3), in Patients with Relapsed/Refractory Small Cell Lung Cancer (SCLC)
Authors: Zhou Di , Byers Lauren A. , Sable Beate , Smit Marie‐Anne Damiette , Sadraei Nooshin Hashemi , Dutta Sandeep , Upreti Vijay V. 
Published: September 2023

AbstractWith the promise of a potentially single‐dose curative regimen, CAR‐T cell therapies have brought a paradigm shift in the treatment and management of hematological malignancies with 6 approved products in the USA. However, there are no approved CAR‐T cell therapies for solid tumors. Herein, we report the clinical pharmacology profile of AMG 119, the first CAR‐T cell therapy targeting delta‐like ligand 3 (DLL3), in patients with relapsed/refractory (R/R) small cell lung cancer (SCLC). AMG 119 demonstrated robust cellular expansion with long‐lasting cell persistence and a favorable exposure–response relationship. AMG 119 has been demonstrated to be clinically safe and well tolerated at the doses tested, with no dose‐limiting toxicities (DLTs) reported. This is the first publication of the clinical pharmacology profile of a CAR‐T cell therapy in SCLC, with encouraging cellular kinetics data supporting the potential for CAR‐T cell therapy in solid tumor space.
Target Occupancy and Functional Inhibition of JAK3 and TEC Family Kinases by Ritlecitinib in Healthy Adults: An Open‐Label, Phase 1 Study
Authors: Martin David A. , Telliez Jean‐Baptiste , Pleasic‐Williams Susan , Zhang Ying , Tierney Brendan , Blatnik Matthew , Gale Jeremy D. , Banfield Chris , Zhou Yifan , Lejeune Alexandre , Zwillich Samuel H. , Stevens Erin , Tiwari Neeraj , Kieras Elizabeth , Karanam Ashwin 
Published: September 2023

AbstractRitlecitinib is a small molecule in clinical development that covalently and irreversibly inhibits Janus kinase 3 (JAK3) and the TEC family of kinases (BTK, BMX, ITK, TXK, and TEC). This phase 1, open‐label, parallel‐group study assessed target occupancy and functional effects of ritlecitinib on JAK3 and TEC family kinases in healthy participants aged 18‐60 years who received 50 or 200 mg single doses of ritlecitinib on day 1. Blood samples to assess ritlecitinib pharmacokinetics, target occupancy, and pharmacodynamics were collected over 48 hours. Target occupancy was assessed using mass spectroscopy. Functional inhibition of JAK3‐dependent signaling was measured by the inhibition of the phosphorylation of its downstream target signal transducer and activator of transcription 5 (pSTAT5), following activation by interleukin 15 (IL‐15). The functional inhibition of Bruton's tyrosine kinase (BTK)‐dependent signaling was measured by the reduction in the upregulation of cluster of differentiation 69 (CD69), an early marker of B‐cell activation, following treatment with anti‐immunoglobulin D. Eight participants received one 50 mg ritlecitinib dose and 8 participants received one 200 mg dose. Ritlecitinib plasma exposure increased in an approximately dose‐proportional manner from 50 to 200 mg. The maximal median JAK3 target occupancy was 72% for 50 mg and 64% for 200 mg. Ritlecitinib 50 mg had >94% maximal target occupancy of all TEC kinases, except BMX (87%), and 200 mg had >97% for all TEC kinases. For BTK and TEC, ritlecitinib maintained high target occupancy throughout a period of 48 hours. Ritlecitinib reduced pSTAT5 levels following IL‐15‐ and BTK‐dependent signaling in a dose‐dependent manner. These target occupancy and functional assays demonstrate the dual inhibition of the JAK3‐ and BTK‐dependent pathways by ritlecitinib. Further studies are needed to understand the contribution to clinical effects of inhibiting these pathways.
Effect of diabetes mellitus on association between galectin‐3 andH2FPEFscore in patients with unexplained dyspnea and a preserved left ventricular ejection fraction
Authors: Dogdu Orhan , Karasu Mehdi , Karaca Yücel , Harman Murat 
Published: September 2023

AbstractObjectivesThe aim of this study was to investigate the effect of diabetes mellitus (DM) on the association between Galectin‐3 (Gal‐3) and the H2FPEF score in patients with unexplained dyspnea and a preserved left ventricular ejection fraction (LVEF).MethodsA cross‐sectional observational study was conducted on patients with unexplained dyspnea and a preserved LVEF in the Cardiology Department of Elazıg Medical Park Hospital, Turkey. The patients were evaluated based on the presence of DM and the H2FPEF score. Gal‐3 levels were compared between groups, and the effect of DM on Gal‐3 was assessed. The level of statistical significance in all tests was set atp < .05.ResultsGal‐3 and H2FPEF scores were higher in patients with DM (p < .001 andp = .027, respectively). Gal‐3 and HbA1C values were elevated in patients with moderate to high H2FPEF scores (p < .01 andp = .036, respectively). DM and Hypertension were more prevalent in patients with moderate to high H2FPEF scores (p = 0.024,p < 0.001, respectively). A strong correlation was observed between Gal‐3 and the H2FPEF score (r = 0.375,p < .001). Gal‐3 could predict patients with a moderate to high H2FPEF score using a cut‐off value of 14.7, with a sensitivity of 69% and specificity of 67% (AUC: 0.702).ConclusionsGal‐3 serves as an independent predictor of the H2FPEF score in the presence of DM, and the diagnostic capability of Gal‐3 for Heart Failure with preserved LVEF remains unaffected by DM.
Preliminary PET imaging of [11C]evobrutinib in mouse models of colorectal cancer, SARS‐CoV‐2, and lung damage: Radiosynthesis via base‐aided palladium‐NiXantphos‐mediated 11C‐carbonylation
Authors: Boyle Amanda J. , Lindberg Anton , Tong Junchao , Zhai Dongxu , Liu Fang , Vasdev Neil 
Published: September 2023

Evobrutinib is a second‐generation, highly selective, irreversible Bruton's tyrosine kinase (BTK) inhibitor that has shown efficacy in the autoimmune diseases arthritis and multiple sclerosis. Its development as a positron emission tomography (PET) radiotracer has potential for in vivo imaging of BTK in various disease models including several cancers, severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2), and lipopolysaccharide (LPS)‐induced lung damage. Herein, we report the automated radiosynthesis of [11C]evobrutinib using a base‐aided palladium‐NiXantphos‐mediated 11C‐carbonylation reaction. [11C]Evobrutinib was reliably formulated in radiochemical yields of 5.5 ± 1.5% and a molar activity of 34.5 ± 17.3 GBq/μmol (n = 12) with 99% radiochemical purity. Ex vivo autoradiography studies showed high specific binding of [11C]evobrutinib in HT‐29 colorectal cancer mouse xenograft tissues (51.1 ± 7.1%). However, in vivo PET/computed tomography (CT) imaging with [11C]evobrutinib showed minimal visualization of HT‐29 colorectal cancer xenografts and only a slight increase in radioactivity accumulation in the associated time‐activity curves. In preliminary PET/CT studies, [11C]evobrutinib failed to visualize either SARS‐CoV‐2 pseudovirus infection or LPS‐induced injury in mouse models. In conclusion, [11C]evobrutinib was successfully synthesized by 11C‐carbonylation and based on our preliminary studies does not appear to be a promising BTK‐targeted PET radiotracer in the rodent disease models studied herein.
Hematopoietic stem cell transplant does not prevent neurological deterioration in infants with Farber disease: Case report and literature review
Authors: Goudie Catherine , Alayoubi Abdulfatah M. , Tibout Pauline , Duval Michel , Maranda Bruno , Mitchell David , Mitchell John J. 
Published: September 2023

AbstractFarber disease (FD) is an inherited autosomal recessive disorder of lipid metabolism. The hallmark of the disease is systemic accumulation of ceramide due to lysosomal acid ceramidase deficiency. The involvement of the central nervous system is critical in this disorder leading to rapid deterioration and death within a few years after birth. Efforts to treat patients by hematopoietic stem cell transplant (HSCT) have resulted in favorable results in the absence of neurological manifestations. We report the outcomes of HSCT in two patients with FD who received early HSCT and had neurological deterioration posttransplant. We also present a new understanding of the limitations of HSCT in FD management based on our observations of the clinical course of the two patients after therapy.