bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor-associated Macrophages (TAMs) in Cancer Resistance; Modulation
by Natural Products
Authors: Lafta Holya A. , AbdulHussein Ali H. , Al-Shalah Saif A. J. , Alnassar Yasir S. , Mohammed Naseer M. , Akram Sally M. , Qasim Maytham T. , Najafi Masoud 
Published: February 2023

Abstract:
Tumor-associated macrophages (TAMs) play a pivotal role in the progression and re-sistance of tumors to different anticancer drugs. TAMs can modulate the tumor microenvironment (TME) in favor of immune system exhaustion. The interactions of TAMs with TME can affect the function of cytotoxic CD8+ T lymphocytes (CTLs) and natural killer (NK) cells. Furthermore, TAMs can induce cancer cell proliferation by releasing some growth factors, such as transforming growth factor (TGF)-β. TAMs have several positive cross-talks with other immune suppressive cells such as regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and cancer cells, leading to the release of growth factors, the prolif-eration of cancer cells and tumor growth. These interactions also can induce invasion and migration of cancer cells, angiogenesis, and metastasis. The inhibition of TAMs is an intriguing strategy for overcoming tumor resistance and suppression of cancer cells. Some natural-derived agents such as melatonin, curcumin, resveratrol, apigenin, and other flavonoids have shown the ability to modulate TME, including TAMs. These adjuvants may be able to boost antitumor immunity through the modulation of TAMs. This review explains the modulatory effects of some well-known naturally derived agents on the activity of TAMs. The modulation of TAMs by these agents may be useful in suppressing tumor growth and invasion.
Overexpression of mTOR in Leukocytes from ALS8 Patients
Authors: Gomes Nathália Augusta , das Chagas Lima e Silva Francisco , de Oliveira Volpe Caroline Maria , Villar-Delfino Pedro Henrique , de Sousa Camila Ferreira , Rocha-Silva Fabiana , Nogueira-Machado José Augusto 
Published: February 2023

Abstract:
The mutated VAPBP56S (vesicle B associated membrane protein – P56S) protein has been described in a Brazilian family and classified as Amyotrophic Lateral Sclerosis type 8 (ALS8). We aimed to study altered biochemical and immunological parameters in cells from ALS8 patients to identify possible biomarkers or therapeutic targets. Wild-type VAPB, VAPBP56S, mTOR, pro-inflammatory cytokines, and oxidant/reducing ELISA, fluorimetry, and spectrophotometry measured balance levels in serum, leucocytes, and cellular lysate from ALS8 patients and Health Controls. Our results showed similar levels of mutant and wild-type VAPB in serum and intracellular lysate (p >0.05) when ALS8 patients and Controls were compared. IL-1β, IL-6, and IL-18 levels in patients and Controls showed no difference, suggesting an absence of peripheral inflammation (p > 0.05). Oxidative metabolic response, assessed by mitochondrial ROS production, and reductive response by MTT reduction, were higher in the ALS8 group compared to Controls (p < 0.05), although not characterizing typical oxidative stress in ALS8 patients. Total mTOR levels (phosphorylated or non-phosphorylated) of ALS8 patients were significantly lower in serum and higher in intracellular lysate than the mean equivalents in Controls (p < 0.05). A similar result was observed when we quantified the phosphorylated protein (p < 0.05). We demonstrate the possibility of using these biochemical and immunological parameters as potential therapeutic targets or biomarkers. Furthermore, by hypothesis,we suggest a hormetic response in which both VAPB forms could coexist in different proportions throughout life. The mutated VAPBP56S production would increase with aging and predominate over the wild-type VAPB levels, determining the onset of symptoms and aggravating the disease.
Significance of Beta-Blocker in Patients with Hypertensive Left Ventricular
Hypertrophy and Myocardial Ischemia
Authors: Koracevic Goran , Mićić Slađana , Stojanovic Milovan , Bozinovic Nenad , Simic Dragan , Lović Dragan , Krstic Nebojsa , Tomašević Ružica Janković 
Published: February 2023

Background:
Arterial Hypertension (HTN) is a key risk factor for left ventricular hypertrophy
(LVH) and a cause of ischemic heart disease (IHD). The association between myocardial ischemia
and HTN LVH is strong because myocardial ischemia can occur in HTN LVH even in the absence of
significant stenoses of epicardial coronary arteries.

Objective:
To analyze pathophysiological characteristics/co-morbidities precipitating myocardial ischemia
in patients with HTN LVH and provide a rationale for recommending beta-blockers (BBs) to
prevent/treat ischemia in LVH.

Methods:
We searched PubMed, SCOPUS, PubMed, Elsevier, Springer Verlag, and Google Scholar for
review articles and guidelines on hypertension from 01/01/2000 until 01/05/2022. The search was limited
to publications written in English.

Results:
HTN LVH worsens ischemia in coronary artery disease (CAD) patients. Even without obstructive
CAD, several pathophysiological mechanisms in HTN LVH can lead to myocardial ischemia. In the
same guidelines that recommend BBs for patients with HTN and CAD, we could not find a single recommendation
for BBs in patients with HTN LVH but without proven CAD. There are several reasons
for the proposal of using some BBs to control ischemia in patients with HTN and LVH (even in the
absence of obstructive CAD).

Conclusion:
Some BBs ought to be considered to prevent/treat ischemia in patients with HTN LVH
(even in the absence of obstructive CAD). Furthermore, LVH and ischemic events are important causes
of ventricular tachycardia, ventricular fibrillation, and sudden cardiac death; these events are another
reason for recommending certain BBs for HTN LVH.
Natural Metabolite Ursolic Acid as an Inhibitor of Dormancy Regulator
DosR of Mycobacterium tuberculosis: Evidence from Molecular Docking,
Molecular Dynamics Simulation and Free Energy Analysis
Authors: Jee Babban , Sharma Prem Prakash , Goel Vijay Kumar , Kumar Sanjay , Singh Yogesh , Rathi Brijesh 
Published: February 2023

Background:
DosR is a transcriptional regulator of Mycobacterium tuberculosis
(MTB), governing the expression of a set of nearly 50 genes that is often referred to as ‘dormancy
regulon’. The inhibition of DosR expression by an appropriate inhibitor may be a crucial step
against MTB.

Objective:
We targeted the DosR with natural metabolites, ursolic acid (UA) and carvacrol (CV),
using in silico approaches.

Methods:
The molecular docking, molecular dynamics (MD) simulation for 200 ns, calculation of
binding energies by MM-GBSA method, and ADMET calculation were performed to evaluate the
inhibitory potential of natural metabolites ursolic acid (UA) and carvacrol (CV) against DosR of
MTB.

Results:
Our study demonstrated that UA displayed significant compatibility with DosR during
the 200 ns timeframe of MD simulation. The thermodynamic binding energies by MM-GBSA also
suggested UA conformational stability within the binding pocket. The SwissADME, pkCSM, and
OSIRIS DataWarrior showed a drug-likeness profile of UA, where Lipinski profile was satisfied
with one violation (MogP > 4.15) with no toxicities, no mutagenicity, no reproductive effect, and
no irritant nature.

Conclusion:
The present study suggests that UA has the potency to inhibit the DosR expression
and warrants further investigation on harnessing its clinical potential.
What is a meta-epidemiological study? Analysis of published literature indicated heterogeneous study designs and definitions
Authors: Puljak Livia , Makaric Zvjezdana Lovric , Buljan Ivan , Pieper Dawid 
Published: February 2023

Aim:
To analyze descriptors/definitions of meta-epidemiological studies as well as study design of articles that were self-described as meta-epidemiological studies.
Methods:
We searched MEDLINE and Embase on 6 August 2019. We extracted definitions of meta-epidemiological studies, as well as study designs, statistics and units of analysis that were reported in studies self-labelled as meta-epidemiological studies.
Results:
We included 175 information sources in the analysis. Definitions of meta-epidemiological studies varied and some studies used the term meta-epidemiological study to describe methodological research-on-research studies. Less than a half of the studies (n = 54; 42.9%) used the two-step meta-epidemiological approach in data analysis. Among studies self-labelled as meta-epidemiological, 9.4% reported registration in PROSPERO and 11% indicated they reported the study in line with PRISMA.
Conclusion:
Research community would benefit from consensus about definition of meta-epidemiological study.
Comparison of intravenous versus topical tranexamic acid in primary total hip arthroplasty: a systematic review and meta-analysis of ten randomized trials
Authors: Fang Yan , Shang Xiaobin 
Published: February 2023

Aim:
The optimal management approach for tranexamic acid (TXA) in primary total hip arthroplasty (THA) is still controversial. This meta-analysis aimed to evaluate the efficacy and safety of intravenous versus topical TXA during THA.
Materials & methods:
PubMed, Google Scholar, Embase and the Cochrane library were searched for all randomized controlled trials comparing topical and intravenous TXA (iTXA) following primary THA. The primary outcome consisted of blood loss including total blood loss, intraoperative blood loss and hidden blood loss (HBL), hemoglobin (Hb) level of postoperative day 1, maximum Hb drop and transfusion incidence. The second outcome included drainage volume, complications and length of stay. Extracted data were statistically analyzed with the Stata11.0.
Results:
A total of ten randomized controlled trials containing 1295 patients were included in the study. A similar effect of transfusion rate, total blood loss, Hb level of postoperative day 1, drainage volume, deep vein thrombosis events and wound complications appeared in the two routes. Intraoperative blood loss (weighted mean difference [WMD] = -12.687, 95% CI: -22.291, -3.083; p = 0.010), HBL (WMD = 14.276, 95% CI: 9.936, 19.459; p < 0.001) and maximum Hb drop (WMD = -0.400, 95% CI: -0.577, -0.222; p < 0.001) were significantly reduced in the intravenous group compared with topical group.
Conclusion:
The present result indicated comparable safety and transfusion rate for intravenous and topical TXA in primary THA, while the intravenous approach demonstrated a smaller intraoperative blood loss, HBL and maximum Hb drop.
Pengaruh Adanya Tambak Udang Vaname Terhadap Pendapatan Pekerja Tambak Sesudah dan Sebelum di Desa Pagubaian, Kabupaten Kaur, Provinsi Bengkulu
Authors: Dewiyanti Reni 
Published: February 2023

Penelitian ini bertujuan untuk mengetahui keadaan perolehan pendapatan yang didapat oleh para pekerja tambak di sekitar usaha tambak udang vaname yakni di Desa Pagubaian, Kabupaten Kaur, Provinsi Bengkulu. Penelitian ini untuk mengetahui pendapatan para pekerja sesudah dan sebelum adanya tambak udang vaname di Desa Pagubaian. Menurut Wilaga “Adanya TBBM Di Desa Remen” menunjukkan bahwa adanya perubahan jumlah pendapatan tenaga kerja dengan rata-rata kenaikan 20,91%, dan memberikan pengaruh kepada masyarakat desa. Metode pengambilan dengan menggunakan purpose sampling dengan karakteristik tertentu dan melakukan secara sengaja terhadap masyarakat dengan adanya tambak udang di desa pagubaian. Penelitian ini merupakan deskriptif kuantitatif, Variabel yang digunakan dalam penelitian ini yaitu pendapatan yang diperoleh para pekerja di daerah sekitar usaha tambak berdiri. Sampel yang digunakan dalam penelitian ini adalah para pekerja di Desa Pagubaian. Teknik analisis data menggunakan kuisioner, yaitu dengan membuat daftar pernyataan tertulis yang telah disusun (kuisioner terbuka). Analisis kuantitatif digunakan untuk menjabarkan hasil dari kuisioner yang telah didapatkan untuk menjabarkan hasil dari kuisioner yang didapatkan dari responden dalam bentuk angka. Hasil penelitian ini menunjukkan bahwa adanya usaha tambak udang vaname memberikan dampak positif terhadap pendapatan pekerja tambak di Desa Pagubaian.
MSMEs Business Continuity Competitiveness during Post-Pandemic from the Lens of Disaster Recovery Business Planning Theory Approach
Authors: Susiang Maria Imelda Novita , Djamil Masydzulhak , Saluy Ahmad Badawi , Siswanti Indra 
Published: February 2023

2020 is the most difficult year in the start-up world due to the Covid-19 pandemic existed since the end of 2019 which forced every effort to turn the direction of strategy. Not a few also experience a crisis in the time of pandemic, so some companies have laid off their employees to reduce the burden of financing. The business sectors most affected are the commercial aviation, travel, oil and gas, automotive and banking sectors. But the business of the MSME sector is also affected due to the availability of raw materials and social restriction regulations. By applying the Action Research methodology from the literature study of post-pandemic phenomena, the study used a compilation data source to support this writing literature research. The focus of this writing is the MSME sector businesses that are still operating in the post-Covid-19 pandemic. Almost all business people in the MSME sector experienced a very drastic decrease in sales turnover, experiencing various marketing and sales constraints, as well as product distribution. Some business actors in the MSME sector are trying to maintain their business or business in the middle until after the Covid-19 pandemic by following government rules and health and security protocols with various efforts observed (observe), identified (to orient), make decisions (decide), and re-activity (to act) by continuously observing, identifying, making decisions, and acting continuously in one unconstrained cycle time. This study employs and implements an OODA loop or cycle. The concept of OODA loop is the concept of repeated analysis to determine the decision of a problem. OODA stands for Observe, Orient (problem identification), Decide (quick decision making), and Act (immediate action). The term cycle or loop comes from this concept because every process repeats until decisions taken are effective and able to have a significant impact in dealing with problems. For this reason, it is recommended that every business actor can try this method as a solution to the challenge of overcoming the economic crisis caused by COVID-19 through the OODA loop.
Sugarcane Growing and the Livehoods of Small-Scale Farmers in Jinja District, Uganda
Authors: Nabalegwa Muhamud Wambede , Tweheyo Robert , Asaba Joyfred , Waibi Muhamed 
Published: February 2023

This study focused on establishing the relationship between sugarcane growing and the livelihood of small-scale farmers in Jinja District. It was guided by three objectives namely: to characterize individual farmers and their farms, establish benefits from sugarcane farming to the farmer’s livelihoods and find out the effect of sugarcane growing on household food security in the area. The study adopted descriptive research design. The target population of this study were sugarcane growing households’ heads and Village Chairpersons of sugarcane out-growers association. The study employed the purposive and simple random sampling techniques. A sample size of 42 respondents from a population of 362 small-scale farmers. The methods of data collection included; use of questionnaires, interviewing, focus group discussions and observation. The study generated both qualitative and quantitative data. The data collected was analysed by computing percentages while qualitative data was analysed by coding and establishing common themes. The study findings revealed that although women are fully involved in sugarcane growing, ownership of farms is dominated by men. The dominant age group among the sugarcane farmers is between 30 to 60 years, with mainly primary education graduates. The average farm size was 3 acres and the larges part of the farm land is devoted to sugarcane growing. There are some positive benefits from sugar growing, though many challenges have been identified. Most smallholder farmers are experiencing food insecurity. Based on the findings of the study it was recommended that there was need to encourage people owning land less than five acres to practice mixed farming, use scientific methods of farming such as intercropping, crop rotation, use fertilizers to facilitate better yields and crop diversification to improve both on their earnings and food security.
STRATEGI PENGEMBANGAN PENDIDIKAN ISLAM MENURUT PROF MOCHAMAD SHOLEH Y.A ICHROM, Ph.D di PERGURUAN MUHAMMADIYAH KOTTABARAT SURAKARTA
Authors: Ramadana Lutfi Hafid , Ali Mohamad 
Published: February 2023

Penelitian ini bertujuan untuk: 1) mendiskripsikan pemikiran strategi pendidikan Islam Prof. Mochamad Sholeh Y.A Ichrom, 2) mendiskripsikan bagaimana konsep pengembangan pendidikan Islam Prof. Mochamad Sholeh Y.A Ichrom dalam perumusan visi dan misi pendidikan di Perguruan Muhammadiyah Kottabarat Surakarta. Penelitian ini merupakan penelitian kualitatif dengan menitikberatkan pada proses metode analisis deskriptif. Penelitian ini merupakan jenis penelitian kepustakaan (library research) dengan tipe diskriptif yaitu untuk mendiskripsikan realitas atau fenomena. Dalam penelitian ini menggunakan pendekatan filosofis, yang digunakan untuk meneliti pemikiran tokoh dan mengungkap dibalik hakekat segala sesuatu yang nampak. Hasil penelitian ini menunjukan sebagai berikut. (1) pemikiran pendidikan Prof. Mochamad Sholeh Y.A Ichrom tentang (a) konsep pengembangan pendidikan islam menurut Prof Sholeh merupakan suatu kegiatan untuk menjaga fitrah tauhid. (b) strategi pengembangan pendidikan islam menurut Prof. Mochamad Sholeh Y.A Ichrom merupakan konsep Ulul Albab. (2) visi dan misi pendidikan di Perguruan Muhammadiyah Kottabarat Surakarta yaitu, Perguruan Muhammadiyah Kottabarat dalam merumusakan visi dan misi pendidikan sangat terinspirasi dengan pemikiran Prof. Mochamad Sholeh Y.A Ichrom. Yang ingin menjadikan lembaga sekolah yang unggul dalam ketauhidan dan keilmuan dan mengupayakan terwujudnya manusia yang berkualifikasi ulul albab. Untuk mewujudkan itu semua Perguruan Muhammadiyah Kottabarat Surakarta yang terdiri dari SD, SMP, dan SMA Muhammadiyah Program Khusus Kottabarat Surakarta menggunakan kurikulum syariah yang terdiri dari lima elemen yaitu al-Quran, Hadits, Kurikulum nasional, Alam Indonesia, dan Perkembangan Internasional.
PERAN MAJELIS ULAMA INDONESIA (MUI) DALAM PROSES DERADIKALISASI DAN MODERASI DI KOTA SURAKARTA
Authors: Suprapto Suprapto , Sumardjoko Bambang , Waston Waston 
Published: February 2023

Masyarakat Kota Surakarta sangat majemuk dan multikultur, sering terjadi Radikalisme di Kota Surakarta yang menimbulkan ketegangan dan konflik antar kelompok. Tujuan penelitian ini adalah untuk 1). Mengetahui tentang Radikalisme dan Moderasi Beragama di Kota Surakarta 2). Mendeskripsikan Proses Deradikalisasi dan Moderasi Beragama di Kota Surakarta 3). Menganalisis peran MUI dalam Proses Deradikalisasi dan Moderasi Beragama di Kota Surakarta 4). Menganalisis faktor-faktor yang Mendukung dan Menghambat Peran MUI dalam Proses Deradikalisasi dan Moderasi Beragama di Kota Surakarta. Penelitian ini merupakan penelitian kualitatif deskrptif. Subyek penelitian ini MUI an obyek penelitiannya adalah masyarakat beragama. Adapun teknik pengumpulan data menggunakan observasi, wawancara mendalam, dokumentasi, dan kuesioner sebagai data pendukung. Kesimpulan penelitian ini adalah pertama, Radikalisme di Kota Surakarta hanyalah imbas dari dari gerakan Islam terdahulu pada awal-awal tahun kemerdekaan dan diera Orde Baru seperti Abdullah Sungkar dan Abu Bakar Ba’asyir hanyalah penerus dari gerakan DarulIslam (DI)/Negara Islam Indonesia (NII) yang diproklamirkan oleh Karto Suwiryo tahun 1949 di Cisampak Tasikmalaya. Kedua, seagai proses Deradikaisasi dan Moderasi Beragama di Kota Surakarta melakukan tutorial pada seminar OSPEK penerimaan Mahasiswa pada tahunajaran baru untuk mencegah terjadinya ekslusivisme, halaqoh Alim Ulama se Jawa-Madura, dan membuat proposal Solo Berseri Menuju Masyarakat Terhormat untuk Indonesia yang kemudian dijadikan Progrmam nasional oleh MUI Pusat. Ketiga, Peran MUI dalam Proses Deradikalisasi dan Moderasi beragama di Kota Surakarta telah mencegah terjadinya takfiri (saling mengkafirkan) diantara kelompok sesame Muslim, penanaman nilai-nilai Islam wasathiyyah, dan misi yang diemban Nabiyullah Muhammad Saw sebagai “Rahmatan Lil ‘Alamin.” Keempat, Sebagai faktor pendukung dan penghambat peran MUI dalam Proses Deradikalisasi dan Moderasi Beragama adalah masyarakat yang multikultur, budaya toleransi, gotong royong, nasionalisme yang kuat. Sebagai faktor penghambat fanatisme yang berlebihan (al-ghuluw), perbedaan ideologi, lemahnya hukum dan keadilan. Disisi lain masih bergejolaknya peristiwa yang menimpa Negara-negara Islam di Timur Tengah dan belahan dunia lainnya.
Tulevaisuusverstaan mahdollisuudet kouludemokratian toteuttamisen välineenä alakoulussa
Authors: Tujula Mikko 
Published: February 2023

Artikkelin tavoitteena on tarkastella, miten kouludemokratian laveus, syvyys ja vaikuttavuus toteutuvat tulevaisuusverstastyöskentelyssä, ja mitkä tekijät mahdollistavat sen. Tutkimusaineisto koostuu yhden alakoulun rehtorin, opettajien ja oppilaiden teemahaastatteluista. Haastatteluita on analysoitu fenomenografista lähestymistapaa hyödyntäen. Analyysin perusteella tulevaisuusverstas on lupaava menetelmä kouludemokratian eri ulottuvuuksien toteutumiseen. Tutkimuskoulussa kaikki oppilaat pääsivät mukaan tulevaisuusverstastyöskentelyyn, oppilaat pystyivät vaikuttamaan moneen kouluyhteisönsä asiaan, ja heillä oli mahdollisuus nostaa haluamansa asiat päätöksentekoon. Kouludemokratian eri ulottuvuuksien toteutumisen mahdollistivat rehtorin antama tuki, asiantuntijaopettajan rooli muutoksen käynnistäjänä, oppilaiden vaikutusmahdollisuuksien kirjaaminen koulun opetussuunnitelmaan, velvoittavat vaikuttamisrakenteet, opettajien ohjaava rooli sekä kehittymishaluinen ja oppilasmyönteinen toimintakulttuuri. Tulosten perusteella tulevaisuusverstasta kannattaisi kokeilla muissakin alakouluissa.

Future workshop as a tool for promoting school democracy in elementary school
Abstract
This study explores future workshop (FW) as a tool for promoting the breadth, depth, and range of school democracy. The data consists of one elementary school’s teachers’, principal’s, and students’ thematic interviews and it was analyzed using research methods typical for a phenomenographic study. The analysis suggests that FW is a good method to promote school democracy. FW involves all the students, and students have been able to affect schools’ matters and bring many matters into consideration. FW needs e.g. principal’s support, binding structures for student participation, and development-oriented school culture, to promote school democracy. FW could be tested more widely in elementary schools.
Keywords: future workshop, participation, school democracy
Folktales in Chinua Achebe’s Things Fall Apart: An Analysis of Folklore/Tribal-lore Function in Igbo Folktales
Authors: Sandhu Anuroop Kaur 
Published: February 2023

‘Folklore’ and ‘Folk life’ (or Tribal lore and Tribal life) are not separate communal dimensions, but are rather a singular composite entity where the folklore emerges from folk life and in turn folk life is regulated by the folklore as land, people and environment form an important context for the creation, propagation, relevance and sustenance of folk practices and cultural expressions. Folklore stores and transmits cultural knowledge, representing the aesthetic and expressive aspect of an indigenous culture, which can be translated into both generalised and highly specific registers through various artistic oral productions, such as folktales, folk songs, myths and legends, and utterances (Puzzles, Jokes and Riddles). Thus, folklore, in a way, is the language of culture which, like any language system, is established and practiced in oral communities through the collective acceptance of certain norms and practices.