bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of soil erosion using the Revised Universal Soil Loss Equation (RUSLE) in Relation to Landslides in Western Mid-hills of Nepal
Authors: Pathak Lalit , Joshi Kamana , Ghimire Pradeep 
Published: January 2023

AbstractAn attempt has been made in this research to assess soil erosion and its spatial distribution by the revised universal soil loss equation (RUSLE) model at Rangun Khola Watershed, western Nepal. The erosion factors were acquired from multiple sources (Satellite images, ALOSPALSAR DEM, SOTER soil database, Esri 2020 land cover map, rainfall database of DHM) and an integrated analysis was carried out in raster format of GIS. A landslide inventory was generated on the basis of satellite images and past literature to validate soil erosion intensity in the area. The result map of the RUSLE model was categorized into six levels based on the erosion severity, and 9.06% of the area was found to be under extremely severe soil erosion risk (> 80 ton ha− 1year− 1) indicating urgent consequences. The frequency ratios for each level of potential erosion susceptible to landside exhibited a linear relationship depicting reasonable and satisfactory level of agreement between the landslide event/location data and the erosion map that validates the model result. The result of this study will be helpful to detect the sensitive zones presenting a priority of protection and offer valuable information that aids decision-makers and user agencies in creating adequate conservation planning programs to stop soil erosion and maintain the natural balance.
Therapeutic Potential of Rlip Loss on Atopic Dermatitis: A Systematic Review
Authors: Ramesh Malvika , Tarbox James , Singh Sharda , Awasthi Sanjay 
Published: January 2023

Abstract
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease and is marked by dry skin and itchy papules that can become excoriated. AD can be caused by the interaction of host factors such as genetic susceptibility, immunologic responses, and skin barrier. The inflammatory environment of AD is characterized by Th2 and skin barrier dysfunction. Reactive oxygen species (ROS) are also responsible for inflammation associated with AD and the pathogenic disease process. Rlip knockdown is found to protect p53 deficient mice from carcinogenesis as well as reduce inflammation. Rlip knockdown also alters various canonical pathways and, in AD, can lead to inflammatory signaling by altering the balance of Th1 and Th2 immune genes involved in the pathogenesis of eczema. Here we suggest upregulation of ALDH3A1, ACVR1C, and IL-13RA2 through Rlip inhibition could serve as a therapeutic target for the treatment of AD through reduction of skin inflammation and maintenance of skin barrier, decreased Th2 immune response, and lowered intracellular calcium signaling involved in skin pain threshold.
Effect of Silver nanoparticles exposure on oxidative stress in blue swimmer crab (Portunus pelagicus)
Authors: Bita Seraj , Ranjbari Nazanin Ghorbani , Kazemi Mohsen 
Published: January 2023

Abstract
Nanotechnology is a new technology that has many potential environmental effects on living organisms, especially aquatic species. This study was carried out to determine the median lethal concentrations (LC50) of silver nanoparticles and its effect on the antioxidant system in the hepatopancreas and muscle tissue of blue swimmer crab (Portunus pelagicus). The LC50 value was determined according to the OECD standard method and after that, the crabs were exposed to sublethal silver nanoparticles concentrations (equivalent to 25, 50 and 75% LC50 AgNPs) for 14 days. To measure the activity of catalase, glutathione superoxide dismutase, glutathione peroxidase, total antioxidant capacity and malondialdehyde, crab were sampled on days 3, 7 and 14. According to the results, the 96 h LC50 value of AgNPs was 13.65 mg/L. In both hepatopancreas and muscle tissue, except glutathione and glutathione peroxidase, the level of catalase, superoxide dismutase and total antioxidant capacity of crabs exposed to 50% LC50 of AgNPs were significantly decreased as compared to the control (p < 0.05). MDA level in hepatopancreas significantly increased in crab exposed to 50% LC50 of AgNPs compared to all tested concentration and control group (p < 0.05), but not in the muscle. In general, crabs exposed to 50% LC50 of AgNPs showed a significant decrease in the levels of catalase, superoxide dismutase and total antioxidant capacity, except in MDA level where it was significantly increased which was indicate that a dose of 50% LC50 of AgNPs had a deleterious effect on the hepatopancreas antioxidant system of blue swimmer crab.
Analysis of age-dependent gene-expression in
human tissues for diabetes comorbidities.
Authors: guzzi Pietro Hiram , Cortese Francesca , Mannino Gaia Chiara , Pedace Elisabetta , Succurro Elena , Andreozzi Francesco , Veltri Pierangelo 
Published: January 2023

Abstract
The study of the relations of type 2 diabetes mellitus (T2DM) disease with other pathologies (comorbidities) together with patient age variation poses a challenge for medical research.
There is evidence that patients affected by T2DM are more likely to develop comorbidities as they grow older. Variation of gene expression can be related to changes in T2DM comorbidities insurgence and progression. Understanding gene expression changes requires the analysis of large heterogeneous data at different scale as well as the integration of different data sources into network medicine models.
Hence, we designed a framework to shed light on uncertainties related to age effects and comorbidity by integrating existing data sources with novel algorithms. The framework is based on the integration and analysis of existing data sources under the hypothesis that changes in the basal expression of genes may be responsible of the higher prevalence of comorbidities in older patients.
Using the proposed framework, we selected genes related to comorbidities from existing databases, then analysed their expression with age at the tissues level. We found a set of genes that changes significantly in certain specific tissues over time. We also reconstructed the associated protein interaction networks and the related pathways for each tissue. Using this mechanistic framework we detected interesting pathways related to T2DM whose genes change their expression with age. We also found many pathways related to insulin regulation and brain activities, which can be used to develop specific therapies. To the best of our knowledge, this is the first study that analyses such genes at the tissue level together with age variations.
Integrated health-related phenotype by Polygenic Risk Scores stratifies risk population for all-cause mortality: A cohort study based on UK Biobank
Authors: Zhao Renjia , Liu Zhenqiu , Zhu Dongliang , Xie Yijing , Yuan Huangbo , Yuan Ziyu , Xu Kelin , Zhang Tiejun , Jiang Yanfeng , Chen Xingdong , Suo Chen 
Published: January 2023

Abstract
Background
Genetic predisposition is a key factor that influences individuals’ risk of multiple health-related outcomes. Genome-wide association studies examine each susceptibility variant's association but usually neglect the combined effect. We aimed to establish a Polygenic Risk Score (PRS), which could quantify genetic contribution for various phenotypes. Subsequently, we assess the association between the genetic surrogate marker and the lifespan utilizing UK Biobank data.
Results
Sex (HR: 1.73, 95% CI = 1.68-1.77), smoking status (HR: 1.78, 95% CI = 1.73-1.83) and BMI (HR per SD: 1.05, 95% CI = 1.04-1.06) were associated with all-cause mortality. iPRS achieved a dose-effect relationship and risk stratification, the highest iPRS with any BMI level could increase from 1.23-1.90 times mortality risk than normal weight population. The same goes for smokers, mortality risk increased from 38 % to 178% due to different genetic predispositions.
Conclusion
We have evaluated the survival probability of all-cause mortality at the genetic level prediction ability of iPRS. It can be an auxiliary instrument for stratifying risk factors with demographic or behavior exposure.
One-year outcomes of trabeculotomy with 120°, 180°, or 360° Schlemm’s canal incision for primary open-angle and exfoliation glaucoma
Authors: Mori Hidetsugu , Yamada Haruhiko , Chihara Tomoyuki , Yoshida Hideyuki , Kaga Ikuko , Oba Shimpei , Takezawa Ryusuke , Takahashi Kanji 
Published: January 2023

Abstract
Purpose: To investigate the surgical outcomes of trabeculotomy ab interno/externo with cataract surgery in patients with primary open-angle glaucoma (POAG) and exfoliation glaucoma (XFG) in a 12-month follow-up study.
Methods: This retrospective study enrolled 95 patients (121 eyes) with POAG or XFG who underwent trabeculotomy ab externo with a metal probe (M-LOT), ab interno with a Kahook Dual Blade® (K-LOT), or ab interno with a 5-0 nylon suture (S-LOT) between January 2015 and October 2022. Within these treatment groups, we assessed intraocular pressure (IOP), the number of IOP-lowering medications, the incidence of postoperative complications including hyphema with niveau and transient IOP spikes, and success rate using Kaplan–Meier survival analysis.
Results: Median IOP was significantly reduced from baseline (p < 0.05) in the three patient groups, but the number of IOP-lowering medications was only significantly reduced in the M-LOT group. Kaplan–Meier cumulative survival analyses showed a lower success rate for K-LOT. M-LOT had the lowest incidences of hyphema and IOP spikes while S-LOT showed the highest incidences of these.
Conclusions: M-, K-, and S-LOT had different surgical outcomes during the 12 months of follow-up, with M-LOT showing the fewest complications. These results will aid in choosing the most suitable trabeculotomy strategy for patients with POAG and XFG.
Bayes Classification using an approximation to the Joint Probability Distribution of the Attributes
Authors: Hosein Patrick , Baboolal Kevin 
Published: January 2023

Abstract
The Naive-Bayes classifier is widely used due to its simplicity and accuracy. However, it fails when, for at least one attribute value in a test sample, there are no corresponding training samples. This is known as the zero-frequency problem and is typically addressed using Laplace Smoothing. Laplace Smoothing does not take into account the statistical characteristics of the neighborhood of the attribute values of the test sample. Gaussian Naïve-Bayes addresses this but the resulting Gaussian model is formed from global information. We propose an approach that estimates conditional probabilities using information in the neighborhood of the test sample. We no longer make the assumption of independence of attributes and consider the joint probability distribution conditioned on the given class. We illustrate the performance on datasets taken from the University of California at Irvine Machine Learning Repository and demonstrate that the proposed approach is simple, robust and outperforms standard approaches.
Analysis and dynamical transmission of tuberculosis model with Treatment effect by using Fractional Operator
Authors: Farman Muhammad , Malik Shahid Mehmood , Akgül Ali , Salamat Nadeem 
Published: January 2023

Abstract
Each year, millions of people die from the airborne infectious illness tuberculosis (TB). Several drug-susceptible (DS) and drug-resistant (DR) forms of the causative agent, Mycobacterium tuberculosis (MTB), are currently common in the majority of affluent and developing nations, particularly in Bangladesh, and completely drug-resistant strains are beginning to arise. In this study, we developed fractional order tuberculosis model with fractal fractional operator by using generalized mittag-leffler kernel. By demonstrating characteristics such the boundedness of solutions, positivity, and the reliance of the solution on the original data, the biological well-posedness of the mathematical model formulation was investigated for TB cases of 2002 to 2017 in KPK Pakistan. Ulam-Hyres stability is also used to assess both local and global aspects of TB bacterial infection. Sensitivity analysis of the TB model with therapy was also examined. The advanced numerical technique is used to find the solution of the fractional-order system to check the impact of fractional parameters. Simulation highlights that all classes have converging qualities and retain established positions with time which shows the actual behavior of bacterial infection of TB. By examining the non-integer order with integer orders we find a better comparative result to maintain the position of non-integer order.
Evaluation of the safety and effectiveness of the disposable endoscope for endoscopic rubber band ligation of internal hemorrhoids: A prospective randomised controlled trial
Authors: Xu Wen , Xia Guili , Li Laihe , Cao Ge , Yan Xianhuan , Dong Ling , Zhu Ying 
Published: January 2023

Abstract
Purpose

We aimed to compare not only the safety and effectiveness of endoscopic rubber band ligation (ERBL) for treating grade II-III internal hemorrhoids using disposable endoscopes versus reusable endoscopes, but also maintenance cost of them.

Method

This was a prospective randomised controlled trial with 42 patients who underwent ERBL for grade II-III internal hemorrhoids using either a disposable endoscope (n = 21) or a reusable endoscope (n = 21). Safety was assessed by postoperative infection rate, in-procedure vital stability, and incidence of device-related adverse events. Effectiveness was assessed by endoscopic image clarity, flexibility, matching between the endoscope and surgical instrument, and therapeutic effect. Cost accounting of maintenance was also estimated.

Results

In terms of safety, although neutrophil count on a postoperative day (POD) 1 in the disposable endoscope group was significantly higher than in the reusable endoscope group (P = 0.008), no patients in either group had a postoperative infection. No life-threatening events, equipment failure or device-related adverse effects occurred during the procedures in either group. In terms of effectiveness, image clarity (P = 0.599) and endoscopic flexibility (P = 0.057) were mildly inferior in disposable endoscope group, but no significant differences were found. Matching between the endoscope and ligating device was 100% in both groups. The therapeutic effects on POD 30 were similar in both groups (P = 0.611). The maintenance cost of reusable endoscope was 214.74RMB per case when disposable endoscope was 0.

Conclusion

Compared with reusable endoscopes, disposable endoscopes are equally safe, feasible, and reliable in ERBL for internal hemorrhoids, and maintenance cost can be totally saved.
Clinical trial registration was completed (ChiCTR2200060014) on May 14, 2022.
Evaluation of long short-term memory versus recurrent neural networks for demand forecasting in supply chains
Authors: Kim Jae-Dong , Lee Jun-Guel , Han Sung Won 
Published: January 2023

Abstract
Supply chain management is used in both the private and public sectors to meet the needs of consumers while maximizing the economic profitability of an organization. However, in the public sector, military logistics focuses on combat readiness, unlike the private sector, which seeks to maximize profits. Therefore, it is necessary to maintain an appropriate supply level to keep state-of-the-art combat weapon systems operational. Spare parts comprise a large proportion of the equipment maintenance costs. Therefore, several companies have consistently attempted to strike a balance between the cost and supply of spare parts by improving the demand forecasting accuracy. Because the demand for spare parts fluctuates based on equipment requirements, accurate demand forecasting is critical. Fortunately, the recent accumulation of maintenance data has led to more opportunities to improve the demand forecasting accuracy.
Clinical study of intraoperative real-time measurement in predicting successful removal of stone fragments during retrograde intra-renal surgery
Authors: Hao Yichang , Li Xin , Ta Pengfei , Liu Ke , Liu Yuqing , Wang Binshuai , Xiao Ruotao , Xu Lifang , Guo Wei , Xiao Chunlei , Zhang Shudong 
Published: January 2023

Abstract
Purpose
To investigate the application value of intraoperative real-time measurement in retrograde intra-renal surgery (RIRS), and to analyze the clinical characteristics of perioperative stones and the factors affecting the efficient removal of stone fragments.
Methods
In RIRS a total of 67 extraction procedures of stones were retrospectively analyzed. Flexible ureteroscopy with 8.4F URF P-5 (Olympus, Tokyo, Japan) and UAS with F12/14 navigator HD (Boston Scientific, Natick, Ma, USA) were employed intraoperatively. Judge the region of stone fragments in the field of vision, which is divided into the region within 1/3 of the diameter, 1/3 to 1/2, 1/2 to 2/3 and more than 2/3. Record whether the stone fragments can be removed through UAS. The size of stone fragments was determined by the electronic caliper. Analyze the surgical video images, and measure the relative endoscopic horizontal size (REHS) and the relative endoscopic maximum size (REMS) of stones and record whether the stone fragments can be removed through UAS.
Results
All operations were successful, and 67 extraction procedures of stones were performed, with 48 cases in the passable group and 19 cases in the non-passing group. The success rate of stone fragments removal in each region was 93.3% in 1/3 region, 86.8% in 1/3 to 1/2 region, 8.3% in 1/2 to 2/3 region and 0% in more than 2/3 region. That is, 88.7% of the stones located in 1/2 region were successfully removed. Comparing the receiver operating characteristic curve (ROC curve) of REHS and REMS, the area under the curve (AUC) of REHS was 0.895 (95% CI: 0.796–0.956), and the AUC of REMS was 0.797 (95% CI: 0.681–0.885); The difference of AUC between the two methods was 0.0981, the Z-statistic was 1.137, P = 0.02555, and the predictive value of REHS was higher than that of REMS. And then the ROC curve of REHS was analyzed. The maximum cutoff value was 0.47, AUC is 0.895 (sensitivity 78.9% and specificity 89.6%). According to the clinical application value of real-time intraoperative measurement, 0.50 was selected as the actual cutoff value, with the AUC 0.811, P < 0.0001 (sensitivity 68.4% and specificity 93.7%). According to the REHSS cutoff value of 0.5 (namely "one-half principle"), the factors that prevent stones from being removed include irregular stone shape, irregular grasping of stones by the stone basket, poor position of the ureteral channel sheath, and hard stone texture and so on.
Conclusion
When the stone basket is utilized for real-time measurement during flexible ureteroscopy, it is possible to determine efficiently and reliably that stone fragments are removed through UAS with the REHS maximum cutoff value of 0.5, namely "one-half principle". This approach of prediction is anticipated to increase operation effectiveness, shorten operation duration, and increase stone removal rate.
Effects of Intravascular Photobiomodulation on Insomnia, Muscle Soreness, and Biochemistry Profiles: An Eight-Year Follow-Up Study
Authors: Lin Yen-Po , Ding Ruei-Sian , Yin Chun-Hao , Chen Yao-Shen , Chen Jin-Shuen , Chang Shin-Tsu 
Published: January 2023

Abstract
Background
Existing reviews indicate that insomnia and muscle soreness are usually managed pharmacotherapeutically. However, pharmacotherapy can lead to numerous side-effects. The non-drug strategy intravascular laser irradiation of blood (iPBM) has been advocated to improve blood circulation and blood cell function to relieve insomnia and muscle soreness symptoms. Therefore, we assessed whether iPBM improves blood parameters and compared drug use before and after iPBM therapy.
Methods
Consecutive patients who received iPBM therapy between January 2013 and August 2021 were reviewed. The associations between laboratory data, pharmacotherapies, and iPBM therapy were retrospectively analyzed. We compared patient characteristics, blood parameters, and drug use within the three months before first treatment and the three months after last treatment. We also compared the changes before and after treatment in patients who received ≥ 10 and 1‒9 iPBM treatments.
Result
We assessed 183 eligible patients who received iPBM treatment. HGB and HCT significantly increased after treatment in both the ≥ 10 and 1–9 iPBM treatment groups (HGB p < 0.001 and p = 0.046; HCT p < 0.001 and p = 0.029, respectively). Pharmacotherapy analysis revealed no significant differences in drug use before and after treatment; though drug use tended to decrease after iPBM.
Conclusion
iPBM therapy is an efficient, beneficial, and feasible treatment that increases HGB and HCT. While the results of this study do not support the suggestion that iPBM reduces drug use, further larger studies using symptom scales are needed to confirm the changes in insomnia and muscle soreness after iPBM treatment.
Differences in lipid and blood pressure measurements between individuals with type 1 diabetes and the general population
Authors: Varkevisser RDM , Mul D , Aanstoot HJ , Wolffenbuttel BHR , Klauw MM van der 
Published: January 2023

Abstract
Background:
Cardiovascular disease (CVD) is a precarious complication of type 1 diabetes (T1D). Alongside glycaemic control, lipid and blood pressure (BP) management are essential for the prevention of CVD. However, age-specific differences in lipid and BP between individuals with T1D and the general population are relatively unknown. We therefore compared total-, LDL-cholesterol, systolic BP (SBP) and diastolic BP (DBP) in individuals with T1D and the general population.
Methods:
Cross-sectional data from individuals with T1D visiting six outpatient clinics in the Netherlands were compared to a background population without diabetes from the Lifelines cohort, a multigenerational cohort from the Northern Netherlands. Descriptive statistics were calculated stratified by age group, sex and medication use.
Results:
In total 2,178 individuals with T1D and 146,822 without diabetes were included in this study. Total- and LDL-cholesterol were lower and SBP and DBP were higher in individuals with T1D in comparison to the background population. When stratified by age and medication use, total- and LDL-cholesterol were lower and SBP and DBP higher in the T1D population. Males with T1D achieved lower LDL-cholesterol levels both with and without medication in older age groups in comparison to females. Females with T1D had up to 8mmHg higher SBP compared to the background population, this difference was not present in males.
Conclusion:
Lipid and BP measurements are not comparable between individuals with T1D and the general population and are particularly unfavourable for BP in the T1D group. There are potential sex differences in the management of LDL-cholesterol and BP.