bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectrum and characteristics of missense substitutions in the genes for NADH dehydrogenase subunits in the mtDNA haplogroups prevailing in Northern Eurasia
Authors: М.В. Голубенко, , А.А. Зарубин, , Н.П. Бабушкина, , Н.В. Тарасенко, , Р.Р. Салахов, , М.С. Назаренко, 
Published: January 2023

На основе анализа последовательностей митохондриальной ДНК (мтДНК), депонированных в базах данных, исследован спектр аминокислотной изменчивости субъединиц комплекса I дыхательной цепи, кодируемых мтДНК, в зависимости от принадлежности к различным гаплогруппам мтДНК. Установлено, что около 20% аминокислот являются полиморфными в исследованном наборе последовательностей, и для 30% полиморфных аминокислот зарегистрировано более одного мутационного события (гомоплазия). Выявлено действие отрицательного отбора для некоторых генов комплекса I в гаплогруппах мтДНК, распространенных преимущественно в северных широтах. Показано, что индекс консервативности аминокислотных замен в генах комплекса I ниже, чем в других генах мтДНК, а для гена ND1 - выше, чем для других генов комплекса I. Для замен в «северных» гаплогруппах мтДНК по сравнению с распространенными в южных широтах выявлены более высокие средние значения показателя MutPred, отражающего величину эффекта замены аминокислоты на структуру и функцию белка и показателя mtDNA selection score.
Based on the analysis of mitochondrial DNA sequences deposited in databases, the spectrum of amino acid variability of the mtDNA-encoded subunits of the respiratory chain complex I was studied depending on mtDNA haplogroup affiliations. It was found that about 20% of amino acids were polymorphic in the studied dataset, and for 30% of polymorphic amino acids more than one mutational event (homoplasy) was registered. The effect of negative selection was revealed for some complex I genes in mtDNA haplogroups, distributed mainly in Northern Eurasia. It has been shown that the conservation index for amino acid substitutions in complex I genes is lower than in other mtDNA genes, and for the ND1 gene this index is higher than for other complex I genes. For the MutPred index and the mtDNA selection score, which reflect the effect of amino acid substitution on the structure and function of the protein, higher average values were registered in the “Northern” mtDNA haplogroups, comparing to the “Southern” haplogroups.
Assessment of the duplication`s pathogenicity detected by chromosomal microarray, in the example of two patients with Duchenne muscular dystrophy
Authors: Ж.Г. Маркова, , М.Е. Миньженкова, , И. В. Шаркова, , М.С. Петухова, , Н.В. Шилова, 
Published: January 2023

Внутригенные делеции и дупликации представляют собой серьезную проблему при оценке результатов хромосомного микроматричного анализа у пациентов с подозрением на моногенное заболевание. Оценка клинической значимости и каузативности таких генетических вариантов, особенно протяженных дупликаций, затруднена, поскольку CNV, затрагивающие один или несколько экзонов гена, могут иметь различные фенотипические эффекты. В статье представлены результаты обследования двух пациентов с направительным диагнозом мышечная дистрофия. У обоих пациентов при проведении хромосомного микроматричного анализа диагностированы внутригенные дупликации в гене DMD. В работе обсуждаются особенности интерпретации таких CNV и предлагаются рекомендации для окончательной постановки генетического диагноза.
Intragenic deletions and duplications are a major problem in the interpretation of the chromosomal microarray results in patients with suspected monogenic disease. Assessing the clinical significance and causation of such genetic variants, especially extended duplications, is difficult because CNV`s affecting one or more gene exons can have different phenotypic effects. The article presents the results of the examination of two patients with an incoming diagnosis of muscular dystrophy. Intragenic duplications in the DMD gene were diagnosed in both patients during chromosomal microarray analysis. The paper discusses the interpretation features of such CNVs and suggests recommendations for confirmation of the of muscular dystrophy genetics diagnosis.
The Period of Evacuation in the Work of K. Erdeli: 1941–1943
Authors: Подгузова М.М. 
Published: January 2023

В статье рассматриваются основные направления творческой деятельности выдающейся советской арфистки Ксении Эрдели в период эвакуации в годы Великой Отечественной войны: с октября 1941 по ноябрь 1943 года. Время, проведенное в тяжелых военных условиях далеко от дома, не только не стало для Ксении Александровны периодом «творческого спада», а, напротив, явилось достаточно насыщенным и плодотворным. Это касается, прежде всего, исполнительской деятельности, а также возобновления в этот период работы в оркестре, которую арфистка завершила в мирное время ещё в 1938 году. Исследование основано на архивных материалах — письмах К. А. Эрдели из эвакуации ассистенту в Московской консерватории М. П. Мчеделову. Как представляется, корреспонденция содержит ценные сведения, позволяющие впервые ввести в научный обиход фактологическую точность биографических событий, а также составить значительно более подробную картину в сфере изучения творчества арфистки вышеназванного периода.
The article examines the main directions of creative activity of the outstanding Soviet harpist Ksenia Erdeli during the years of the Great Patriotic War: from October 1941 to November 1943. The time spent in difficult military conditions far from home, not only did not become a period of "creative decline" for Ksenia Aleksandrovna, but, on the contrary, was quite rich and fruitful. This concerns, first of all, performing activities, as well as the resumption of work in the orchestra during this period, which the harpist completed in peacetime back in 1938. The study is based on archival materials — letters from K. Erdeli from evacuation to an assistant at the Moscow Conservatory M. Mchedelov. It seems that the correspondence contains valuable information that allows for the first time to introduce the factual accuracy of biographical events into scientific use, as well as to compose a much more detailed picture in the field of studying the work of the harpist of the above-mentioned period.
Comparative analysis of the effect of diclofenac sodium and etoricoxib on energy metabolism in rat liver in the acute general cooling model
Authors: Shtrygol’ S.Yu. , Koiro O.O. , Kudina O.V. , Yudkevych T.K. , Gorbach T.V. 
Published: January 2023

When the ambient temperature decreases, physiological mechanisms that prevent heat loss are activated. However, under cold stress hypothermia develops, which significantly disrupts the functioning of the body and can be transformed into life-threatening. Preventive use of nonsteroidal anti-inflammatory drugs, especially diclofenac sodium and etoricoxib, has been found to reduce the severity of cold trauma. Given that their frigoprotective effect can accompany the impact on the synthesis of eicosanoids when exposed to low temperatures, it is advisable to study mechanisms for preventing hypothermia independent of cyclooxygenase, particularly the influence on energy metabolism. The aim of the study was to figure out the effect of diclofenac sodium and etoricoxib on the indicators of energy metabolism in the liver of rats after acute general cooling. Experiments were carried out on 28 sexually mature male rats, which were given diclofenac sodium (7 mg/kg), etoricoxib (5 mg/kg), or solvent 30 minutes before cold trauma intragastrically (in the intact control and pathology control groups). Acute hypothermia was caused by exposure of animals for 2 hours at a temperature of -18°C. Rectal temperature was measured before and after acute general cooling. The content of lactate, pyruvate and adenosine triphosphate in the liver was measured and the lactate/pyruvate ratio was calculated. Diclofenac sodium, unlike etoricoxib, was found to significantly reduce the severity of hypothermia. Both nonsteroidal anti-inflammatory drugs prevent energy metabolism disorders caused by exposure to cold, namely, reducing the concentration of lactic acid and the ratio of lactate/pyruvate, increasing the content of pyruvate and adenosine triphosphate in the liver of animals. Etoricoxib normalizes the content of energy metabolism intermediates to their levels in intact animals. Diclofenac sodium has a similar effect, the expression of which is inferior to the selective cyclooxygenase-2 inhibitor. Therefore, when administered prophylactically before acute general cooling, diclofenac sodium effectively prevents hypothermia in rats, surpassing etoricoxib. Etoricoxib completely prevents a decrease in the content of pyruvate and adenosine triphosphate, as well as the accumulation of lactic acid in the liver. Diclofenac sodium is inferior to etoricoxib in its effect on energy metabolism, which indicates other mechanisms of frigoprotective action of a non-selective cyclooxygenase inhibitor. The frigoprotective and energotropic properties of nonsteroidal anti-inflammatory drugs dissociate.
Improvement of liver fibrosis verification using new minimally invasive markers in patients with chronic diffuse liver diseases
Authors: Stepanov Yu.M. , Didenko V.I. , Klenina I.A. , Tatarchuk O.M. , Petishko O.P. 
Published: January 2023

The aim of our research was to obtain new minimally invasive serum markers of fibrotic changes of liver in patients with chronic diffuse liver diseases of different etiology and compare them with traditional markers. 364 patients aged 30 to 66 years were examined: 221 women (60.7%) and 143 men (39.3%). Depending on the etiological factors, all patients were divided into 4 groups: group I consisted of 108 patients with non-alcoholic fatty liver disease (NAFLD), group II – 143 patients with chronic hepatitis associated with virus C (CHC), group III – 56 patients with alcoholic liver disease (ALD), group IV – 57 patients with toxic drug-induced hepatitis (TH). The control group consisted of 30 practically healthy people. Using correlation and ROC-analyzes, we obtained minimally invasive diagnostics markers that show the risk of developing liver fibrosis. For patients with NAFLD these were the levels of HOMA-IR, TNFα/IL-10 and α1-acid glycopeptide content, which are better in quality of the diagnostic model than the traditional Forns index, APRI, FIB-4, AAR. For patients with CHC, these were the protein-bound hydroxyproline (HPp/b) /HPf ratio, phospholipids content, and IL-6, CD4+ levels, which are better diagnostic models than the traditional Forns index, APRI, FIB-4, AAR. The following markers were obtained for patients with ALD – TNFα levels, HPp/b and glycosaminoglycans content, which are better diagnostic models than the traditional Forns index, APRI, FIB-4, AAR. For patients with TH, these were medium molecular weight peptides content, IL-6/IL-10 ratio and CD4+/CD8+, which are better diagnostic models than the traditional Forns index, APRI, FIB-4, AAR. Thus, new minimally invasive markers of fibrosis in patients with chronic diffuse liver diseases have been obtained.
Albumin solution as an important component of intensive infusion therapy in women with preeclampsia
Authors: Klygunenko O.M. , Kravets O.V. , Marzan O.O. 
Published: January 2023

The aim of the study is to determine the efficiency and effectiveness of albumin solution in intensive infusion therapy for pregnant women with preeclampsia based on measuring indicators of central and peripheral hemodynamics, body water compartments, and markers of inflammation. 60 women were divided into two groups and examined. The first group (n=30) included women whose average age was 30.06±5.13 years, gestation period – 260.18±6.34 days. 16.7% of women in this group had moderate preeclampsia, 83.3% – severe preeclampsia. Patients of this group received standard intensive infusion therapy according to approved treatment protocols. The second group (n=30) included women, whose average age was 30.62±6.02 years, and pregnancy period 258.75±5.74 days. The patients of this group received intensive infusion therapy, like the women of the first group but in combination with a continuous infusion of a 20% albumin solution (8 ml/h – on the 1 st day; 4 ml/h – on the 2nd and 3rd day) and furosemide (0.05 mg/kg/h – on the 1st day; 0.025 mg/kg/h – on the 2nd and 3rd day) for 72 hours starting from the moment of the end of vaginal delivery or Cesarean section surgery. The comparative analysis showed that the dynamics of changes in the main indicators of homeostasis, hemodynamics, body water compartments and markers of inflammation in parturient women with preeclampsia strongly depend on the type of intensive infusion therapy. In women with preeclampsia, continuous administration of a 20% albumin solution immediately after delivery ensures the normalization of body water compartments till the 7th day of the postpartum period. It is the result of a rapid decrease in the total volume of fluid (by 17.2%, p<0.001 from the baseline) and interstitium (by 31.8%, p<0.001 from the prenatal level). The provided treatment in parturient women with preeclampsia helps to ensure a eukinetic type of blood circulation from the 5th day of the postpartum period already. It is also accompanied by the restoration of adaptation mechanisms that participate in maintaining the proper functioning of the cardiovascular system. The use of albumin and furosemide solution infusion reduces the degree of the background inflammatory process by 3.8 times (according to the index of inflammatory activity IL-6/IL-10) which comes along with preeclampsia.
Dianas or Drudges? Women's status in the Last Ice Age
Authors: Bahn Paul G. , Clifford Elle 
Published: January 2023

In recent decades there have been a number of endeavours to re-examine women’s lives during the last Ice Age. For far too long, the view of ‘man-the-hunter’ and woman as ‘gatherer, cook and child minder’ was an unchallenged hypothesis, and without doubt, this simplistic view of early hunter-gatherer’s division-of-labour practices was ripe for revision. Unfortunately, it led to a number of over-zealous assertions: that women were big game hunters too, and as such, could not have been dominated by men. Breaking such stereotypes about prehistoric women is the message delivered in a recent documentary and accompanying book called ‘Lady Sapiens.’ But are such views about the roles of men and women in pre-history based on anything more than wishful thinking and result in fresh mythologising? Is there any archaeological evidence that allows us to assume anything about the economic activities of men and women in these early prehistoric cultures?
IMPLEMENTASI PERJANJIAN SEWA MENYEWA TANAH OLEH PT. KAI KEPADA PT. HERONA EXPRESS PEKALONGAN
Authors: Layaliya Dewi Hasna , Suhendar Heris , Budiman Satria 
Published: January 2023

Transaksi ekonomi dilakukan manusia dalam melengkapi kebutuhannya. Salah satunya yakni sewa-menyewa seperti perjanjian sewa tanah yang dilakukan PT. KAI dengan PT. Herona Express Pekalongan. Namun, PT. KAI merubah perjanjian tersebut di mana penyewa diminta meninggalkan tanah yang disewa dengan alasan akan digunakan sebagai operasional PT.KAI. Padahal masa sewanya belum habis dan penyewa tidak melanggar ketentuan perjanjian. Kemudian penyewa diberikan tanah di lokasi baru untuk dibangun kembali disertai perjanjian yang baru. Penelitian ini merupakan penelitian kepustakaan dengan pendekatan kualitatif. Hasil penelitian ini menunjukkan Implementasi sewa menyewa tanah oleh PT. KAI kepada PT.Herona Express bahwa perjanjian sewa tanah dimulai pada 2010. Kemudian di tahun 2014 diperpanjang pada hari Selasa, 08 Juli 2014 di Bandung dengan Perjanjian Sewa Aset PT. KAI (Perrsero) No.Hk..221/VII/1/KA-2014. Terkait objek sewa PT. Herona Express Pekalongan luasnya 15 m2 dengan biaya Rp. 46,020,000 jangka waktu sewa 4 tahun 11 bulan mulai 01 Juni 2014 - 30 April 2019. Analisis akad ijarah terhadap implementasi sewa menyewa tanah oleh PT. KAI kepada PT. Herona Express Pekalongan dari segi rukun, syarat, dan prosedur pengakhiran akad ijarah sudah sesuai syara’. Dalam pelaksanaannya, terjadi perubahan perjanjian yang diperbolehkan sebab mengutamakan hajat umum dengan adanya pembangunan foodcourt, kenyamanan penyewa, serta adanya pemberian kompensasi berupa relokasi. Oleh karena itu, jika dianalisis spesifik dengan akad ijarah tindakan yang dilakukan oleh PT. KAI kepada PT. Herona Express Pekalongan diperbolehkan dalam akad ijarah.
Qadın futbolunun aktual problemləri ( Psixoloji hazırlıq)
Authors: Muradov Ə. Ə. , Əliyev İ. Ə. , Mustafayev R. Y. 
Published: January 2023

«Futbolda güclü olan qalib gəlmir, qalib olan güclü sayılır ». Frants Bakenbauer. Qədim dövrlərdən bəri qadınlar müstəqillik,azadlıq və kişilərlə bərabər hüquqlar üçün mübarizə aparırlar. Qadın azadlığı dərəcəsi və onun ictimai həyatda iştirakı tarixən cəmiyyətin inkişafının göstəricisi sayılır.
Xüsusilə də əgər sahədə zərif cinsin nümayəndələridirsə. Bir çox idman növlərində texniki bacarıq baxımından qadınların kişilərdən daha aşağı olmayan yüksək nəticələr əldə edə etdiklərinin şahidi olmuşuq.
Yüksək dərəcəli futbolçuların hazırlıq sisteminin təkmilləşdirilməsi
Authors: Əliyev İ. S. , Qarayev G. Q. , İbrahimli A. M. , Hüseynov Ə. F. 
Published: January 2023

Müasir futbolda təlim-məşq prosesinin makrosilsilələrində futbolçularda sürət keyfiyyətinin inkişafı ilə fərdi texniki ustalığın təkmilləşdirilməsi idman elmində ən aktual mövzu olaraq qalır. Bu istiqamətdə apardığımız tədqiqat, elmi araşdırmalar və təhlilər ümümi və xüsusi fiziki hazırlıq metodikasında ciddi düzəlişlər etməyə imkan verəcəkdir, çünki futbolçuların fərdi texniki hazırlığının sürət hərəki qabiliyyəti fonunda səmərəlliyinin artması ideyası futbolda ən az tədqiq olunan aktual bir sahədir.
Məktəblərdə fiziki tərbiyənin inkişafı və təkmilləşdirilməsi
Authors: Babanlı Y.M. 
Published: January 2023

Annotasiya: Məqalədə məktəblərdə fiziki tərbiyə dərslərinin məzmunu, inkişafı və təkmilləşdirilməsindən bəhs olunur. Fiziki tərbiyə dərslərinin düzgün qurulmasında şagirdlərin fiziki sağlamlığının və psixoloji xüsusiyyətlərinin nəzərə alınması, əsas məsələ kimi vurğulanmışdır. Həmçinin, məqalədə şagird şəxsiyyətinin və sağlam həyat obrazı vərdişinin formalaşmasında fiziki tərbiyə dərslərinin rolu da göstərilmişdir.
Иследование функционального состояния сердца баскетболистов в динамике тренировочного процесса
Authors: N.A. Musayeva  , V.A. Adigozalova  , Rahimova N.G.  , G.D. Yusifov  
Published: January 2023

Исследованы адаптационные и восстановительные возможности сердечно-сосудистой системы студентов-баскетболистов в условиях выполнения анаэробной физической нагрузки (тест Руффье) на подготовительном, соревновательном и переходном этапах тренировочного процесса. Анализ результатов проведенного исследования показал, что на переходном этапе адаптационные и восстановительные функции системы кровообращения превосходят таковые на подготовительном и соревновательном этапах. Установлена разная степень совершенства механизмов, регулирующих адаптационные и восстановительные возможности организма баскетболистов.
Məktəblilərin yeniyetməlik yaş dövründə fiziki tərbiyəsi
Authors: Babanlı Yusif 
Published: January 2023

Məqalədə yeniyetməliyin müxtəlif yaş dövrlərində şagirdlərin fiziki tərbiyəsindən bəhs olunur. Fərqli və fərdi yanaşma prinsipi ilə şagirdlərin psixoloji xüsusiyyətlərini, fiziki və əqli inkişafını nəzərə almaqla fiziki tərbiyənin tədrisi metodikasına da toxunulmuşdur. Həmçinin məqalədə yeniyetmə yaşı dövründə fiziki tərbiyənin vəzifələri, dərs formasında aparılan məşğələlərin xüsusiyyətləri və texnologiyası da geniş verilmişdir.
Məktəb psixoloqunun işində korrelyasiya analizinin tətbiq edilməsi
Authors: Valiyeva S M , Nagiyev G M 
Published: January 2023

Təcrübələr psixologiyanı dəqiq elm hesab edir. Yalnız düzgün şəkildə aparılmış eksperiment nəzəri ehtimalları elmi nəticələrə çevirə, psixoloji və sosial fenomenlərin əsl obyektiv səbəblərini tapmağa kömək edə bilər. Eksperimentdə nəticələrin alınması üçün əsas və vacib olan verilənlərin statistik emalı metodudur.
Bu metodlar mürəkkəbliuinə və tətbiq sahələrinə görə fərqlənirlər. Bunlara həm sadə orta riyazi, həm də faktorlu reqressiya analizinin hesablanması aiddir. Statistik metodların eksperimentdə tətbiqi nəticəsi isə seçmələrin elə bir nəticəsidir ki, onu məlum dərəcədə ehtimal payı ilə baş məcmuya yaymaq olar.
Misal üçün belə bir fakt məlumdur ki, insan haqqında fikir yaratmaq üçün ilkin təəssüratlar daha mühüm hesab olunur və sonrakı təəssüratla müqayisədə daha çox rol oynayır.
Prediction and analysis of power consumption and power loss at industrial facilities
Authors: Abdullazyanov E. Y. , Gracheva E. I. , Alzakkar A. , Nizamiev M. F. , Shumikhina O. A. , Valtchev S. 
Published: January 2023

THE PURPOSE. Conduct a study to improve the reliability of forecasting the magnitude of power consumption and power losses at an industrial enterprise.METHODS. Methods are used to determine and predict the parameters of consumption and losses of electricity at industrial facilities.RESULTS. To clarify the magnitude of electricity losses, it is proposed to use coefficients that take into account the type of load curves and show the ratio of the values of the sum of the squares of currents (powers) of the variable load curve and the values of the sum of average currents (powers), that is. the ratio of power losses during load operation according to variable and uniform schedules (Kgraph), as well as a coefficient that takes into account the topology of the circuit (Ktop). The study of radial and main circuits of networks was carried out and the losses of electricity were determined using the proposed coefficients. The values of equivalent resistances of shop circuits of networks of various topologies are calculated. The operational data of the section of the workshop network are given. It was revealed that with a constant technological process, an increase in the equivalent resistance of the network circuit is due to an increase in the resistance of the contacts of switching devices installed on the lines. The value of the estimated supply of electricity was determined using the parameter of the average value of the equivalent resistance. At the same time, the error in calculating the estimated supply in relation to the actual annual supply of electricity amounted to 2,63%. According to the retrospective values of the average equivalent resistance of the circuit, it is possible to determine the predicted value of this parameter using the average value of the coefficient of change in the equivalent resistance. These characteristics of the scheme are recommended to be used in the assessment and forecasting of losses and the estimated supply of electricity, which will increase the reliability of the predicted parameters for industrial facilities.