bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic profiling of zinc homeostasis mechanisms inPseudomonas aeruginosathrough data-dependent and data-independent acquisition mass spectrometry
Authors: Meyer Annaliese C. S. , McIlvin Matthew R. , Lopez Paloma , Searle Brian C. , Saito Mak A. 
Published: January 2025

AbstractZinc is central to the function of many proteins, yet the mechanisms of zinc homeostasis and their interplay with other cellular systems remain underexplored. In this study, we employ data-dependent acquisition (DDA) and data-independent acquisition (DIA) mass spectrometry to investigate proteome changes inPseudomonas aeruginosaunder conditions of different zinc availability. Using these methods, we detected 2143 unique proteins, 1578 of which were identified by both DDA and DIA. We demonstrated that most of the previously described Zn homeostasis systems exhibit proteomic responses that follow similar trends to those seen in transcriptomics studies. However, some proteins that are considered instrumental in Zn homeostasis, notably those in Zn transporter ZnuABC, were not detected by our methods, although other proteins of other uptake systems were abundant. Furthermore, changes in abundance of multiple Zn-metalloproteins and Zn-independent homologs were clearly observable, with respective increases and decreases when Zn was provided, though the magnitude of these changes varied. Most of the Zn-metalloproteins observed were located in one of two Zur-regulated operons between PA5534 and PA5541. This study provides a view of Zn homeostasis mechanisms that is complementary to existing transcriptomics investigations: as gene transcripts are not strictly proportional to the actual distribution of proteins within a cell, analysis of the proteome offers another way to assess the relative use and importance of similar or ostensibly redundant systems in different conditions and can highlight shifts in metal prioritization between metalloproteins.
Exploration of the effect of fractional elements in nonlinear transmission lines
Authors: Condon Marissa , Hayes Brendan , Cullinane Niall 
Published: January 2025

Purpose
The purpose of this paper is to explore how fractional derivatives affect the transient and steady-state behaviour of nonlinear transmission lines. This problem is of significance for high-frequency design of systems such as high-speed sampling systems and radar systems.

Design/methodology/approach
This paper shall consider the transient and steady-state responses of nonlinear transmission lines when fractional derivatives are considered. A lumped-parameter model is considered and the product-integration implicit trapezoidal rule shall be used for simulations.

Findings
The important observation is that small deviations of the order of the derivative from an integer order can have a significant effect on the transient and steady-state behaviour. This includes a change in the speed of the wave on the transmission line and on its damping.

Originality/value
The work is novel as it uses a lumped-parameter model with nonlinear capacitors and explores the effect on the dynamical behaviour when fractional derivatives are present. This is in contrast to the typical approach of using a partial differential equation derived under certain assumptions such as the nature of the nonlinear capacitor.
How does AI awareness affect employees’ voice behavior in the service industry? A transactional theory of stress perspective
Authors: He Changqing , Xiong Huyun , Cai Wenjun , Song Jun 
Published: January 2025

Purpose
This study aims to explore the impacts of service industry employees’ AI awareness on their voice behavior while also considering the dual mediating roles of voice efficacy and job insecurity, as well as the moderating role of trait competitiveness.

Design/methodology/approach
The sample comprises data from a two-wave longitudinal survey of 203 employees in the service sector. This study examined all the hypotheses using Mplus 8.0.

Findings
This study confirms that service sector employees’ AI awareness has significant negative effects on both promotive and prohibitive voice behaviors. Voice efficacy can mediate the negative impact of AI awareness on promotive voice. Both voice efficacy and job insecurity can mediate the negative impact of AI awareness on prohibitive voice. Furthermore, employees’ trait competitiveness can weaken the negative impact of employees’ AI awareness on their voice efficacy.

Practical implications
Managers should first investigate employees’ AI awareness and then adopt targeted managerial strategies to promote their voice behavior.

Originality/value
This study contributes to the literature related to the consequences of AI awareness by linking AI awareness to employee voice behavior. Furthermore, this study deepens our understanding of how AI awareness affects employee voice behavior by proposing voice efficacy (i.e. the efficacy pathway) and job insecurity (i.e. the safety pathway) as key mediating mechanisms. Moreover, this study advances our understanding of when AI awareness influences employee voice behavior by identifying the moderating role of trait competitiveness.
The impact of strategic agility on the strategic orientation during the Covid-19 crisis in Jordanian medical and pharmaceutical industries companies
Authors: Abufardeh Fatima Mohammad , Albloush Ahmad 
Published: January 2025

Purpose
This study aims to explore the impact of strategic agility on strategic orientation and its dimensions (retrenchment, perseverance, innovation and exit strategies) in Jordanian medical and pharmaceutical industries companies during the COVID-19 crisis.

Design/methodology/approach
The researchers relied on a descriptive-analytic methodology. The study population consisted of 23 companies in the medical and pharmaceutical industries in Amman, Jordan. The sampling units were the top managers of these companies, represented by chief executive officers and main department managers. The sample size was 193. Questionnaires were distributed to collect the data, while the valid for analysis were 165 questionnaires.

Findings
The results showed that strategic agility has a positive effect on strategic orientation, as well as on, perseverance, and innovation strategies, but it has an opposite effect on retrenchment strategy. However, it has no statistically significant effect on the exit strategy.

Originality/value
This pioneering study is uniquely valuable through filling a gap in the literature by examining the dynamic relationship between strategic agility and strategic orientation, offering practical insights for decision-makers to enhance resilience that contributes to overcoming the COVID-19 and future crises.
Infrastructures, Riverscapes, and the Governance of Mobility: The Evros/Meriç River and the Infrastructuring of Nature
Authors: Teunissen Peter 
Published: January 2025

AbstractThis paper investigates the interplay between infrastructures, geophysical environments, and mobility regimes by focusing on the Evros/Meriç River, as the border between Turkey, Greece, and the EU. Situated in the fields of Infrastructure Studies, Mobility Studies, and Critical Border Studies, this paper examines how border regimes are enrolled in the riverscape, thereby shaping who can cross the river‐as‐border and under what conditions. Through an interdisciplinary research practice of “montaging”, which integrates ethnographic research, literary and visual analysis, cartography, and textual analysis, this paper analyses how geophysical environments and socio‐technical formations co‐constitute racialising border regimes. Using the conceptual framework of infrastructure as ecology, this paper highlights the relationality between geophysical environments, border regimes, and how people‐on‐the‐move navigate these landscapes. In so doing, this paper explores a critical way of thinking about “natural borders” and “infrastructures” and aims to put forward analytical tools for documenting and analysing bordering practices.
IGF2BP3 Triggers STAT3 Pathway by Stabilizing SRC RNA in an m6A‐Dependent Manner to Promote Lymphatic Metastasis in LUAD
Authors: Ding Jiapei , Wang Xuequan , Yang Haihua , Zhang Lele , Ying Yongquan , Pi Wenhu , Deng Guozhong , Zhu Yaqun 
Published: January 2025

ABSTRACTLymph node metastasis significantly affects the NSCLC patients' staging, treatment strategy, and prognosis. Studies have shown that IGF2BP3, an oncofetal protein and an m6A reader, overexpresses and correlates to lymph node metastasis and worse overall survival in histopathological studies including NSCLC, but its mechanism needs further study. This study explored IGF2BP3's function and mechanism in LUAD lymphatic metastasis using public databases, a human LUAD tissue microarray, human LUAD cells, and a lymphatic metastasis model in male BALB/c nude mice. Firstly, we proved that IGF2BP3 overexpression was positively correlated to patients' lymph node metastasis and worse overall survival in bioinformatics and a human LUAD tissue microarray analysis. IGF2BP3 was knocked out or overexpressed in human LUAD cell lines. Functionally, IGF2BP3 facilitated NCI‐H1299, NCI‐H358, and A549 cell growth, migration, invasion, and EMT in vitro, and promoted tumorigenesis, lymphangiogenesis, and lymphatic metastasis of NCI‐H1299 cells in BALB/c nude mice. Mechanically, RIP, RNA pull‐down assay, MeRIP, mRNA stability assays, rescue experiments, and immunohistochemical assays were conducted. IGF2BP3 was demonstrated to bind to the m6A site of the 3′UTR region of SRC, stabilizing its mRNA and activating the downstream STAT3 signaling pathway and lymphatic growth factors such as VEGF‐C, therefore affecting lymphatic metastasis. The cell migration and EMT function of IGF2BP3 were partially rescued by utilizing SRC siRNA or AZD0530, an SRC inhibitor. This study demonstrated that IGF2BP3 promotes lymphatic metastasis in LUAD via activating the m6A‐SRC‐STAT3‐VEGFC signaling axis, indicating that IGF2BP3 is a potential therapeutic target to overcome metastasis in LUAD patients.
Supporting Wildlife Restoration in Eastern States via State Wildlife Action Plans
Authors: Elbroch L. Mark , Vucetich John A. , Rose Christa , Bruskotter Jeremy T. 
Published: January 2025

ABSTRACTThe biodiversity crisis is driven by extinction at two scales: the global extinction of species and the local extirpation of populations (i.e., range contraction). Local extirpations are especially acute in the eastern United States, which has lost a substantial portion of its native mammalian fauna. Species restoration in the U.S., therefore, should be utilised more to revitalise and restore degraded systems. State wildlife agencies can elevate discussions about species restoration and facilitate internal capacity to conduct restoration projects by including locally extirpated species in State Wildlife Action Plans, which are currently under revision, and will guide state conservation programs for the next 10 years.
Effect of insulin sensitivity, insulin secretion, and beta cell function on the remission of type 2 diabetes: A post hoc analysis of the IDEATE trial
Authors: Wu Xianglin , Huang Qiuyue , Ding Yi , Cao Qiuyu , Jiang Youjin , Xu Yu , Zhao Zhiyun , Xu Min , Lu Jieli , Wang Tiange , Ning Guang , Wang Weiqing , Bi Yufang , Xu Yuchen , Li Mian 
Published: January 2025

AbstractAimsTo compare the probability of achieving diabetes remission in individuals with different phenotypes of insulin sensitivity, insulin secretion, and beta cell function and further detect the effects of diet, exercise, and lifestyle education intervention on these indexes.MethodsThree‐hundred and one participants who had glycated haemoglobin (HbA1c) data at baseline and after intervention were included for this post hoc analysis. We used the multi‐way analysis of variance to assess the differences between the diabetes remission and non‐remission groups or between intervention groups in changes of the indexes of insulin sensitivity, insulin secretion, and beta cell function. Furthermore, logistic regression analysis was used to identify the association between the diabetes remission and baseline and change of each insulin index.ResultsParticipants with a higher disposition index (DI) or higher adaptation index at baseline were more likely to achieve diabetes remission. The diabetes remission group had a significantly greater increase in AUCc‐pep0–30/AUCgluc0–30, DI, and adaptation index compared with the non‐remission group, while there were no between‐group differences in indexes of insulin sensitivity. Participants with greater increases in insulin secretion and beta cell function were more likely to achieve diabetes remission. Indexes of beta cell function improved in all intervention groups, while the diet intervention induced significant improvement compared with lifestyle education.ConclusionsThese findings supported the importance of aggressively implementing intensive lifestyle interventions for individuals with type 2 diabetes at an early stage of the disease, when beta cell function was not yet significantly impaired, to promote achieving diabetes remission.
Urban food insecurity and its determinants among migrant households
Authors: Mazenda Adrino , Althaus Catherine , Tani Massimiliano 
Published: January 2025

AbstractThis study utilized the Linear Probability Model to examine the determinants of food insecurity among migrant households in the Gauteng City region of South Africa. 13,616 households were selected using random sampling and a cross‐section design. The study findings showed that age and level of education reduce the probability of skipping a meal among internal and international migrant households. Having medical aid is negatively associated with food insecurity – a sign of affordability. Part‐time jobs increase the likelihood of experiencing food insecurity for both internal and international migrants. Access to indigency and government support were associated with a higher probability of food insecurity among international migrants. Government support in food parcels is also associated with food insecurity for internal migrants. In contrast, ethnicity has no statistically significant effect on food security for internal migrants relative to native residents. Policy focus on inclusivity in social service provision, employment access and urban agriculture can likely help improve the food insecurity status of internal and international migrant households in the Gauteng City Region.
A new index for climate‐induced migration uncertainty
Authors: Salisu Sulaiman , Salisu Afees 
Published: January 2025

AbstractThe impact of climate change on the world has been significant, leading to various efforts to reduce its risks. This study aims to create a new index to measure the uncertainty surrounding migration due to climate change. It uses a range of international newspapers with a global readership. Although climate change has increasingly influenced migration decisions in vulnerable areas, there is still a lack of quantitative research exploring this connection, which our study aims to address. The index indicates a growing trend in climate‐induced migration decisions, especially over the last two decades, supporting the study's purpose. We also present empirical results that validate the depressing effect of the uncertainty index on per Capita GDP growth at global, regional and country‐specific levels. The index has various practical applications and can be useful for future research.
Indirect Effects of Self‐Differentiation and Mentalization on Family of Origin Health and Marital Satisfaction Among Korean Adults
Authors: Kim Sunyoung , Woo Sungbum 
Published: January 2025

ABSTRACTThis study explored the structural relationships among family of origin health, self‐differentiation, mentalization, and marital satisfaction, focusing on indirect effects and gender differences. Data from 400 married Korean adults aged 30–49 were analyzed using structural equation modeling and multigroup analysis. Results revealed that all paths were significant except the direct impact of family‐of‐origin health on marital satisfaction. Indirect effects analyses confirmed significant individual and sequential indirect effects of self‐differentiation and mentalization. Gender differences emerged: mentalization significantly influenced marital satisfaction in men but not in women, while family of origin health directly impacted marital satisfaction in women but not in men. These findings highlight the importance of incorporating self‐differentiation and mentalization into couple counseling and suggest the need for gender‐sensitive interventions to address marital satisfaction effectively.
A Comprehensive Study on Adverse Reactions of Benzoyl Peroxide (BPO) in Dermatological Aesthetics Utilizing the FAERS Database
Authors: Zhou Siyuan , Yan Su , Ming Shaopeng 
Published: January 2025

ABSTRACTBackgroundBenzoyl peroxide (BPO) is widely used in dermatological aesthetics for treating acne and other skin conditions. However, its potential adverse reactions remain a concern.AimsThis study aimed to investigate the application of BPO in dermatological aesthetics, analyze its associated adverse reactions, and provide insights into patient safety.MethodsThe study analyzed adverse reaction reports related to BPO in the Food and Drug Administration's Adverse Event Reporting System database from 2004 to 2024. Demographic characteristics, types of adverse reactions, and specific issues related to the novel drug EPSOLAY (5% microencapsulated BPO) were examined.ResultsThe findings reveal that BPO users are predominantly female (74.18%), with a significant proportion falling within the 18–44 age group (37.45%). The most common adverse reactions involve skin and subcutaneous tissue disorders (36.34%), including skin swelling, pain, and burning sensations. Reports on EPSOLAY indicate adverse reactions such as erythema, pruritus, and skin exfoliation, but no tumor‐related reports have been recorded.ConclusionsBPO usage in dermatological aesthetics is associated with various adverse reactions, primarily affecting the skin. The introduction of EPSOLAY has not altered the adverse reaction profile significantly. However, the risk of BPO decomposing into the carcinogen benzene under certain conditions necessitates enhanced patient education, improved production processes, and continuous post‐marketing surveillance to ensure drug safety.
The Novel HLA‐C*01:250 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual
Authors: Yang Hua‐yue , Gong Song‐song , Ma Li , Hu Xiao‐zhuang , Cai Xiao‐hong 
Published: January 2025

ABSTRACTThe HLA‐C*01:250 allele differs from HLA‐C*01:02:01:01 by a single non‐synonymous nucleotide change in exon 7.
Four New Null HLA Alleles Characterised From Bone Marrow Volunteers: B*18:248N, B*54:49N, C*05:303N and C*12:428N
Authors: Loginova Maria , Smirnova Daria , Paramonov Igor 
Published: January 2025

ABSTRACTFour novel null‐alleles are described from bone marrow donors of Russian Registry.
Clinical Guidelines for Canine Transmissible Venereal Tumour Treatment: Systematic Review and Meta‐Analysis
Authors: Pimentel Pedro Antônio Bronhara , Giuliano Antonio , Odatzoglou Petros , Ignatenko Natalia , Wenceslau Raphael Rocha , Almeida Isabella Oliveira , da Silva Paloma Helena Sanches , Costa Mariana de Pádua , Horta Rodrigo dos Santos 
Published: January 2025

ABSTRACTThe treatment of canine transmissible venereal tumour (CTVT) has evolved since its initial description in 1810. Initially considered untreatable in the early 20th century, extensive research over time has significantly advanced our understanding of its aetiopathogenesis. This led to successful chemotherapy treatments, which have shown superior outcomes compared to surgical interventions. Vincristine, in particular, has proven effective in treating CTVT. However, the development of chemoresistance underscores the need to explore alternative therapeutic options. This systematic review provides a comprehensive analysis of CTVT treatment practices from 1950 to 2023, aiming to establish a gold standard and enhance clinical decision‐making. Initially, 3633 studies were identified, with 42 meeting the eligibility criteria. Our findings suggest that vincristine sulphate monotherapy is the recommended first‐line treatment for CTVT. Administering vincristine intravenously at a dosage of 0.5–0.75 mg/m2 weekly for 4–6 sessions resulted in a 93.1% (67.4%–100%) complete response rate in dogs. Extending the treatment to eight sessions increased the complete response rate to 98.9% (83.3%–100%). Radiation therapy, lomustine and doxorubicin are viable second‐line treatment options; however, extensive cohort studies are required to confirm their efficacy in achieving remission in vincristine‐resistant cases. Additionally, no clear criteria could be established for initiating treatment with drugs other than vincristine in previously untreated dogs. Surgery is considered a third‐line option. Notably, complete remission is anticipated following recommended systemic and local therapies in nearly all cases. Despite concerns about chemoresistance, current guidelines indicate a favourable response to suggested treatments even in resistant cases.
Stigma, self‐styling and ‘forced accents’ among English L2 speakers in Spain
Authors: Codó Eva , Collins Carly 
Published: January 2025

AbstractThis paper examines the relationship between shame, stigma and accent for non‐native English speakers in Spain. The low English competence of the Spanish population frequently constitutes a source of individual and collective stigma – which includes the apparent undesirability of Spanish‐sounding English. Drawing on semi‐structured interviews conducted in Barcelona, this paper explores participant perceptions around L2 English and accent. The results show how keenly aware they are of the stigma surrounding Spanish‐sounding English. Also revealed is how some people may engage in stylisation of (American) English in order to reap the benefits of sounding like highly proficient speakers, and to distance themselves from a locally stigmatised English‐speaking persona. These attempts can however backfire, as speakers may potentially be perceived as inauthentically ‘forcing’ an accent. The paper argues for the need to pay close attention to the evolving indexicalities of English and the contrasting social personas in specific localities.