bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aqueous‐Based Inorganic Colloidal Halide Perovskites Customizing Liquid Scintillators
Authors: Lian Huiwang , Zhang Wenxia , Zou Rui , Gu Simin , Kuang Rongyi , Zhu Yunfei , Zhang Xinyue , Ma Chong‐Geng , Wang Jing , Li Yang 
Published: September 2023

AbstractCompared to solid scintillators and organic liquid scintillators, aqueous‐based liquid scintillators (AbLS) have more superiority in highly flexible scalability, yet are now limited by their low light yield (≈100 photons MeV−1). Here, aqueous‐based inorganic colloidal halide perovskites with high photoluminescence quantum yield (PLQY) of three primary color luminescence up to 88.1% (red), 96% (green), and 81.8% (blue) are respectively synthesized, and a new generation of colloidal perovskite‐mediated AbLS (PAbLS) with light yield increased in comparison with the commercial scintillator AbLS is fabricated. This paper exhibits that the excellent PLQY and colloidal dispersion of halide perovskites benefit from poly(ethylene glycol) modification and this modification ensures the vacancy inhibition and formation of defect–free surfaces in an aqueous solution. Moreover, their high luminescent emission can be maintained for 100 days at low temperatures, and such modification also promises the heat‐to‐cold customization of operating temperature even in ice below 0 °C. Finally, depending on the light yield of around 3058 and 8037 photons MeV−1 at room temperature and low temperature, PAbLS with shape/size scalability exhibit their robust radiation hardness (dose rate as high as 23 mGy s−1) and conceptual application potential in high‐energy ray radiation detection from every angle of 360°.
Tailoring Enantiomeric Chiral Channels in Metal‐Peptide Networks: A Novel Foldamer‐Based Approach for Host‐Guest Interactions
Authors: Kim Jaewook , Hong Jungwoo , Park Mi Jeong , Lee Hee‐Seung 
Published: September 2023

AbstractDesigning chiral channels in organic frameworks presents an ongoing challenge due to the intricate control of size, shape, and functionality required. A novel approach is presented, which crafts enantiomeric chiral channels in metal‐peptide networks (MPNs) by integrating short foldamer ligands with CuI clusters. The MPN structure serves as a 3D blueprint for host‐guest chemistry, fostering modular substitution to refine chiral channel properties at the atomic scale. Incorporating hydrogen bond networks augments guest molecule interactions with the channel surface. This approach expedites enantiomer discrimination in racemic mixtures and incites adaptable guest molecules to take on specific axially chiral conformations. Distinct from traditional metal‐organic frameworks (MOFs) and conventional reticular architectures, this foldamer‐based methodology provides a predictable and customizable host‐guest interaction system within a 3D topology. This innovation sets the stage for multifunctional materials that merge host‐guest interaction systems with metal‐complex properties, opening up potential applications in catalysis, sensing, and drug delivery.
Performance Enhancement of Organic Ternary Logic Circuits through UV Irradiation and Geometry Optimization
Authors: Panigrahi Debdatta , Hayakawa Ryoma , Aimi Junko , Wakayama Yutaka 
Published: September 2023

AbstractMultivalued logic (MVL) circuits offer higher information density compared with conventional binary logic circuits. However, achieving a proper balance between logic states and a low‐voltage gain remains a challenge in MVL devices. This study proposes two strategies to address this problem: using the optical absorption of organic semiconductors and optimizing device geometry. A ternary inverter is fabricated using a series circuit consisting of an antiambipolar transistor with a heterojunction of C8‐BTBT and PTCDI‐C8 semiconductors and a PTCDI‐C8 transistor. Although the inverter exhibits three distinct logic levels, it suffers from an inadequate voltage balance between the ternary logic states. To overcome this, UV light irradiation is employed first to modulate the transistor characteristics, thus improving the output voltage level and input voltage range of the logic ½ state. Subsequently, the channel length of the PTCDI‐C8 transistor is optimized to further enhance the voltage transfer characteristics of the inverter. Through these combined techniques, ideal output voltage levels are achieved for all three logic states along with an enhanced voltage gain during the transition from the logic ½ state to the logic 0 state. This work is thus an advancement toward reliable, efficient organic ternary logic circuits.
Multi‐Controllability of Ambipolar Photoconductivity in Transition Metal Dichalcogenides Van der Waals Heterostructures
Authors: Elbanna Ahmed , Wang Zeng , Liu Yuanda , Wu Qing Yang Steve , Liang Xinan , Liu Hongfei , Ooi Zi En , Jiang Mengting , Deng Jie , Sun Handong , Pan Jisheng , Shen Ze Xiang , Teng Jinghua 
Published: September 2023

Abstract2D transition metal dichalcogenides (TMDs) and their van der Waals heterostructures possess great potential for optoelectronic applications thanks to their strong quantum confinement and flexibility in bandgap engineering. Photodetection based on TMDs utilizing photoconductance typically exhibits positive photoconductance resulting from the generation of photocarriers upon illumination. This study reports a SnSe2/MoS2 photodetector operating over a broadband range from deep ultraviolet to infrared wavelengths with not only a high responsivity and self‐powered feature but also ambipolar photoresponse with both positive and negative photoconductances to multi‐control parameters of wavelength, gate voltage, and laser power. The transition from positive to negative photoconductance by gate voltage and laser power indicates that charge recombination and interlayer exciton trapping result in negative photoconductance. The coexistence and controllable positive and negative photoconductance hold potential for multifunctional optoelectronic devices responding to multi‐control parameters.
Function Graded Carbon Micro‐Structures for Powerless Photon Sensing with Intriguing µm‐Scale Position Sensitivity
Authors: Karamati Amin , Qu Wangda , Bai Xianglan , Wang Xinwei 
Published: September 2023

AbstractPartial laser treatment is introduced to carbon‐based microfibers to generate excellent photon sensing capability without bias. This treatment brings about a Seebeck coefficient distribution along the sample's length, out of which a photovoltage with no external bias is generated and sensed. Using a line‐shaped laser spot, carbon microfiber (CMF), graphene microfiber (GMF), and graphene aerogel fiber (GAF) are investigated for their response to µm‐scale photon irradiation. A higher sensitivity for the incident photon is found for the GAF with no position sensitivity. More Seebeck coefficient variation is also observed for the GAF considering the amount of laser power used for the laser treatment. A weaker Seebeck coefficient spatial variation is observed for the GMF compared with the GAF. However, its photovoltage shows an abrupt magnitude change from the laser‐treated region to the non‐treated one. Despite the low spatial variation of the Seebeck coefficient for the CMF, it features an excellent and accurate position‐sensitive photoresponse with polarization change over a distance of ≈100 µm. Such unique capability prompts novel applications in using partially annealed CMF for sensing the position of optical beams at the microscale.
Copper(I)‐Catalyzed Decarboxylative N‐Phosphorylation: Modular Preparation of N‐Acyl Iminophosphoranes Using Dioxazolones and Phosphines
Authors: Park Jinhwan , Krishnapriya Anattil Unnikrishnan , Park Yeongmi , Kim Minsuk , Reidl Tyler W. , Kuniyil Rositha , Son Jongwoo 
Published: September 2023

AbstractDioxazolones and phosphines have been used to access N‐acyl iminophosphoranes in copper(I) catalysis under simple thermal conditions. The synthetic utility of this protocol is demonstrated by a broad range of substrates with an excellent atom‐economy. The optimization process showed that copper demonstrated as catalytic amount toward the targeted transformation. Functionalization studies of N‐acyl iminophosphoranes were also conducted. Our reaction protocol is compatible with an example of a bioactive motif‐containing N‐acyl iminophosphorane analogue.
Ni‐Carbon Microtube/Polytetrafluoroethylene as Flexible Electrothermal Microwave Absorbers
Authors: Wu Lihong , Wang Guizhen , Shi Shaohua , Liu Xiao , Liu Jun , Zhao Jinchuan , Wang Guilong 
Published: September 2023

AbstractFlexible microwave absorbers with Joule heating performance are urgently desired to meet the demands of extreme service environments. Herein, a type of flexible composite film is constructed by homogeneously dispersing a hierarchical Ni‐carbon microtube (Ni/CMT) into a processable polytetrafluoroethylene (PTFE) matrix. The Ni/CMT are interconnected into a 3D conductive network, in which the huge interior cavity of the carbon microtube (CMT) improves impedance matching and provides additional hyper channels for electromagnetic (EM) waves dissipation, and the hierarchical magnetic Ni nanoparticles enhance the synergistic interactions between confined heterogeneous interfaces. Such an ingenious structure endows the composites with excellent electrothermal performance and improves their serviceability for application under extreme environments. Moreover, under a low fill loading of 3 wt.%, the Ni/CMT/PTFE (NCP) can achieve excellent low‐frequency microwave absorption (MA) property with a minimum reflection loss of −59.12 dB at 5.92 GHz, which covers almost the entire C‐band. Relying on their brilliant MA property, an EM sensor is designed and achieved by the resonance coupling of the patterned NCP. This work opens up a new way for the design of next‐generation microwave absorbers that meet the requirements of EM packaging, proofing water and removing ice, fire safety, and health monitoring.
Decoupling the Capacity Fading in Ni‐Rich Layered Materials during High‐Temperature Cycling in the Full‐Cell System
Authors: Kim Minji , Lee Wontae , Lee Eunkang , Kim Jaeyoung , Kim Jae‐Uk , Lee Seongeun , Hwang Sunhyun , Park Dohyung , Cho Kwanghwan , Yoon Won‐Sub 
Published: September 2023

AbstractThe performance of commercial lithium‐ion batteries (LIBs) tends to degrade over time owing to the deterioration of key components, including cathode, anode, and electrolyte. To enhance performance, it is crucial to gain insights into the actual deterioration state of each element. Here, the high‐temperature deterioration of a Ni‐rich layered cathode is investigated, which is widely used in electric vehicles. In the refresh process after a prolonged cycle, a significant recovery of the lattice structure predominantly occurs in the discharge region. This pseudo‐deterioration of the Ni‐rich cathode within the full‐cell system is mainly due to the consumption of the Li‐ion forming the solid electrolyte interphase layer at the graphite anode during the cycle. Moreover, irreversible deteriorations that are not restored through the refresh process are observed in both charge and discharge regions. Structure analyses reveal that the long‐term cycling at the high temperature leads to a mixed fading of charge and discharge via various deterioration such as the formation of NiO‐like rock salt phase on the cathode surface and increased cation disorder in the bulk. These findings deepen the understanding of the deterioration behavior of Ni‐rich cathodes in full‐cell systems, providing insights for enhancing the performance of high‐temperature cycling.
Thiol‐Specific Silicon‐Containing Conjugating Reagent: β‐Silyl Alkynyl Carbonyl Compounds
Authors: Teng Shenghan , Zhang Zhenguo , Li Bohan , Li Lanyang , Tan Melinda Chor Li , Jia Zhenhua , Loh Teck‐Peng 
Published: September 2023

AbstractSite‐specific modification of thiol‐containing biomolecules has been recognized as a versatile and powerful strategy for probing our biological systems and discovering novel therapeutics. The addition of lipophilic silicon moiety opens up new avenues for multi‐disciplinary research with broad applications in both the medicinal and material sciences. However, adhering to the strict biocompatibility requirements, and achieving the introduction of labile silicon handle and high chemo‐selectivity have been formidable. In this paper, we report silicon‐based conjugating reagents including β‐trialkylsilyl and silyl ether‐tethered alkynones that selectively react with thiols under physiological conditions. The pH‐neutral, metal‐free and additive‐free reaction yields stable products with broad substrate compatibility and full retention of silicon handles in most cases. Besides simple aliphatic and aromatic thiols, this approach is applicable in the labeling of thiols present in proteins, sugars and payloads, thereby expanding the toolbox of thiol conjugation.
The Ambiguous Origin of Thermochromism in Molecular Crystals of Dichalcogenides: Chalcogen Bonds versus Dynamic Se−Se/Te−Te Bonds
Authors: Thomas Sajesh P. , Singh Ashi , Grosjean Arnaud , Alhameedi Khidhir , Grønbech Thomas Bjørn E. , Piltz Ross , Edwards Alison J. , Iversen Bo B. 
Published: September 2023

AbstractWe report thermochromism in crystals of diphenyl diselenide (dpdSe) and diphenyl ditelluride (dpdTe), which is at variance with the commonly known mechanisms of thermochromism in molecular crystals. Variable temperature neutron diffraction studies indicated no conformational change, tautomerization or phase transition between 100 K and 295 K. High‐pressure crystallography studies indicated no associated piezochromism in dpdSe and dpdTe crystals. The evolution of the crystal structures and their electronic band structure with pressure and temperature reveal the contributions of intramolecular and intermolecular factors towards the origin of thermochromism—especially the intermolecular Se⋅⋅⋅Se and Te⋅⋅⋅Te chalcogen bonds and torsional modes of vibrations around the dynamic Se−Se and Te−Te bonds. Further, a co‐crystal of dpdSe with iodine (dpdSe‐I2) and an alloy crystal of dpdSe and dpdTe implied a predominantly intramolecular origin of the observed thermochromism associated with vibronic coupling.
A Photolabile Curcumin‐Diazirine Analogue Enables Phototherapy with Physically and Molecularly Produced Light for Alzheimer's Disease Treatment**
Authors: Kuang Shi , Zhu Biyue , Zhang Jing , Yang Fan , Wu Bo , Ding Weihua , Yang Liuyue , Shen Shiqian , Liang Seven H. , Mondal Prasenjit , Kumar Mohanraja , Tanzi Rudolph E. , Zhang Can , Chao Hui , Ran Chongzhao 
Published: September 2023

AbstractThe development of Alzheimer's disease (AD) drugs has recently witnessed substantial achievement. To further enhance the pool of drug candidates, it is crucial to explore non‐traditional therapeutic avenues. In this study, we present the use of a photolabile curcumin‐diazirine analogue, CRANAD‐147, to induce changes in properties, structures (sequences), and neurotoxicity of amyloid beta (Aβ) species both in cells and in vivo. This manipulation was achieved through irradiation with LED light or molecularly generated light, dubbed as “molecular light”, emitted by the chemiluminescence probe ADLumin‐4. Next, aided by molecular chemiluminescence imaging, we demonstrated that the combination of CRANAD‐147/LED or CRANAD‐147/ADLumin‐4 (molecular light) could effectively slow down the accumulation of Aβs in transgenic 5xFAD mice in vivo. Leveraging the remarkable tissue penetration capacity of molecular light, phototherapy employing the synergistic effect of a photolabile Aβ ligand and molecular light emerges as a promising alternative to conventional AD treatment interventions.
2‐Oxoquinoline‐based‐thiosemicarbazones as multitargeting neurotherapeutics against Alzheimer's disease: In vitro and in silico studies of MAO and ChE inhibitors
Authors: Basri Rabia , Fatima Shamool , Jalil Saquib , Imran Aqeel , Fatima Noor , Syed Asad , Bahkali Ali H. , Iqbal Jamshed , Shafiq Zahid 
Published: September 2023

AbstractAlzheimer's disease (AD) presents a multifactorial neurological disorder with multiple enzyme involvement in its onset. Conventional monotherapies fall short in providing long‐term relief, necessitating the exploration of alternative multitargeting approaches to address the complexity of AD. Therefore, the design, synthesis, and in vitro and in silico evaluation of 2‐oxoquinoline‐based thiosemicarbazones 9a–r as multipotent analogs, able to simultaneously inhibit the cholinesterase (ChE) and monoamine oxidase (MAO) enzymes for the potential treatment of AD, are reported. In the in vitro experimental evaluation of MAO and ChE inhibition, all tested compounds demonstrated remarkable potency exhibiting nonselective inhibition of both MAO‐A and MAO‐B, and selective inhibition of acetylcholinesterase (AChE) over butyrylcholinesterase (BChE), with 9d, 9j, and 9m evolving as lead compounds for MAO‐A, MAO‐B, and AChE, displaying IC50 values of 0.35 ± 0.92, 0.50 ± 0.02, and 0.25 ± 0.13 μM, respectively. Moreover, the kinetic studies revealed that all tested compounds inhibited all three enzymes through a competitive mode of inhibition. Furthermore, the molecular docking studies of the most active compounds revealed several crucial interactions, particularly hydrogen bonding interactions. These interactions were observed between the nitrogen and sulfur atoms of thiosemicarbazone and the nitrogen and oxygen atoms of the quinoline ring with various amino acids, suggesting the strong interactions of these compounds with the enzymes.
Investigating dynamics of lentiviral vector secretion from HEK293T producer cells using a fractionated perfusion system
Authors: Timmins Lauren M. , Erickson Patrick , Parekkadan Biju 
Published: September 2023

AbstractMammalian cell culture is quickly becoming the go to engineering vehicle to mass produce viral vectors in a manner that is safe, convenient, reproducible, and cost and scale effective. Human embryonic kidney (HEK293) cells, in particular, have been utilized and customized (via differentiated transgene expression, modified culture parameters, addition of cytostatic culture agents) to increase vector yields. However, less attention has been made to understanding innate processes within the cells (such as, immune response, cell cycle, metabolism) themselves to better control or increase viral vector product yield. Accordingly, herein, the variation in viral production was studied from HEK cells over time using a one‐way perfusion system and bioreactor to study the impact of external factors on secretion dynamics without retrotransduction. Specifically, the impact of cell density on viral titer, transduction efficiency, and LDH, was studied. Next, we look at the impact of using an inflammatory reporter cell line on viral output, and the secretion dynamics from HEK cells when we use sodium butyrate (cell cycle arrest agent). Lastly, we assess how downregulation of the PDK pathway increases viral titer. Altogether, we investigated the impact of various interventions to increase transient protein expression and viral output from HEK cells in a controlled and measurable environment to ultimately increase the efficiency of HEK cells for downstream clinical applications.
Importance of three physiological models for teaching the carbohydrates metabolism
Authors: Garófalo Sofía Judith , Galagovsky Lydia , Alonso Manuel 
Published: September 2023

AbstractIn this work extensive misconceptions of university students' —from nutrition area— about the metabolism of carbohydrates (CHM) in the human organism have been documented. The results lead to consider their difficulties concerning the learning of a complex set of imbricated biochemical models involved. Pursuant to these considerations, three physiological models are proposed as conceptual axes around which CHM in the human organism could be taught, in order to avoid fragmentation in students' knowledge and to give simple physiological contexts where to integrate those biochemical models. These contexts are: (a) a physiological model of the carbon cycle, (b) a physiological model of blood glucose uptake and homeostasis, and (c) a physiological model of the availability of small metabolites.
Exploring goal taxonomies using the goal‐based outcome tool in children and young people's mental health settings
Authors: Mok Wing Chi , Vainieri Isabella , Jacob Jenna 
Published: September 2023

AbstractFormulating goals in therapy may facilitate young people and parents/carers' engagement in mental health support settings. A number of goal taxonomies have been developed, which involve organising goals set at the outset of therapy into themes. Goal taxonomies are considered useful for service planning and outcome purposes. In order to build on the knowledge about what young people choose as goals, and to best support good practice, it is important to explore the links and differences between the existing goal taxonomies. A systematic review was conducted to identify goal taxonomies based on goals set using the goal‐based outcome (GBO) tool. Framework analysis was conducted to investigate the extracted goal taxonomies. Overall, four core concepts were identified: “Goals targeting specific issues, symptoms, emotions, and behaviours,” “Return and engage in activities,” “Personal growth goals” and “Interpersonal goals.” Goals regarding specific issues, personal growth and interpersonal relationships were present in most studies. Using these overarching core concepts could be useful for practitioner‐level, or service‐level organisation of goal data, for activities such as service planning and delivery.
Composition of methionine and association with lysine and tryptophan in subtropically adapted maize breeding lines
Authors: Duo Hriipulou , Muthusamy Vignesh , Mishra Subhra J. , Chhabra Rashmi , Chand Gulab , Mehta Brijesh K. , Devlash Rakesh , Guleria Satish K. , Pal Digvender , Kumar Rajesh , Zunjare Rajkumar U. , Hossain Firoz 
Published: September 2023

AbstractBackground and ObjectivesMaize protein lacks essential amino acids such as methionine, lysine, and tryptophan. Limited information exists on the composition and variation of kernel methionine. This study assessed methionine variability and its relationship with lysine and tryptophan in 48 maize inbreds at three locations.FindingsAnalysis of variance revealed significant variations for kernel methionine (0.031%–0.305%), lysine (0.118%–0.389%), and tryptophan (0.014%–0.090%). CML591 (0.305%), CML596 (0.286%), and CML421 (0.284%) showed the highest methionine content. The average methionine contents were comparable in quality protein maize (0.156%) and normal (0.150%) lines. Methionine showed no correlation with lysine (r = 0.001) and tryptophan (r = 0.032), while lysine and tryptophan showed a strong positive correlation (r = 0.740). CML165 (methionine: 0.272%, lysine: 0.320%, and tryptophan: 0.090%), CML186 (methionine: 0.254%, lysine: 0.389%, and tryptophan: 0.083%), and HKI163 (methionine: 0.252%, lysine: 0.331%, and tryptophan: 0.084%) were promising genotypes considering all three amino acids.ConclusionsMultilocation experiment revealed genetic variation in methionine, lysine, and tryptophan among the 48 inbreds. No negative correlation between the amino acids indicates the possibility of developing cultivars high in methionine, lysine, and tryptophan.Significance and NoveltyIdentified nutrient‐rich inbreds will serve as valuable germplasm in maize biofortification programs. This is the first report on methionine variability and its relationship with lysine and tryptophan in subtropical maize.