bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overall survival and morbidity are not associated with advanced age for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a single centre experience
Authors: Cheng Ernest , Shamavonian Raphael , Mui Jasmine , Hayler Raymond , Karpes Josh , Wijayawardana Ruwanthi , Barat Shoma , Ahmadi Nima , Morris David L. 
Published: April 2023

Abstract

Objectives
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has enabled better prognosis for patients with peritoneal surface malignancies. However, in older age groups, short -and long-term outcomes are still perceived as poor. We evaluated patients aged 70 and over and determine if age is a predictor of morbidity, mortality and overall survival (OS).

Methods
A retrospective cohort analysis was performed on CRS/HIPEC patients and categorised by age. The primary outcome was overall survival. Secondary outcomes included morbidity, mortality, hospital and incentive care unit (ICU) stay and early postoperative intraperitoneal chemotherapy (EPIC).

Results
A total of 1,129 patients were identified with 134 aged 70+ and 935 under 70. There was no difference in OS (p=0.175) or major morbidity (p=0.051). Advanced age was associated with higher mortality (4.48 vs. 1.11 %, p=0.010), longer ICU stay (p<0.001) and longer hospitalisation (p<0.001). The older group was less likely to achieve complete cytoreduction (61.2 vs. 73 %, p=0.004) and receive EPIC (23.9 vs. 32.7 %, p=0.040).

Conclusions
In patients undergoing CRS/HIPEC, age of 70 and above does not impact OS or major morbidity but is associated with increased mortality. Age alone should not be a limiting factor in selecting CRS/HIPEC patients. Careful multi-disciplinary approach is needed when considering those of advanced age.
Effect of electron temperature on formation of travelling waves in plasma: Kinetic and hydrodynamic models
Authors: Chizhonkov Eugene V. , Frolov Alexander A. 
Published: April 2023

Abstract
The kinetic formulation of the model problem of plasma waves excitation by a powerful short laser pulse is numerically studied for the first time. Kinetic and simplest hydrodynamic plasma models are also compared for the problem under consideration. It is shown that the considered hydrodynamic models do not provide good approximations to the solution to the Vlasov kinetic equation, namely, one leads to discontinuous solutions and the other has a significant qualitative distinction. At a low plasma temperature, the effect of non-isothermicity of the process is small, but it can lead to significant distortions of the solution during further heating. The results obtained here imply that the first two moments of the distribution function are not enough to describe the plasma hydrodynamics; higher-order moments should be used.
Computational methods for multiscale modelling of virus infection dynamics
Authors: Grebennikov Dmitry S. 
Published: April 2023

Abstract
Virus infection dynamics is governed by the processes on multiple scales: on the whole organism level, tissue level, and intracellular level. In this paper, we develop a multi-scale multi-compartment model of HIV infection in a simplified setting and the computational methods for numerical realization of the model. The multiscale model describes the processes from various scales and of different nature (cell motility, virus diffusion, intracellular virus replication). Intracellular replication model is based on a Markov chain with time-inhomogeneous propensities that depend on the extracellular level of virions. Reaction diffusion equations used to model free virion diffusion in the lymphoid tissue have moving sources, which are determined by the positions of the infected cells (immune cell motility model) and the rate of virion secretion from them (intracellular model). Immune cell motility model parameterizes the intercellular interaction forces, friction and the stochastic force of active cell motility. Together, this allows for a proper description of the intracellular stochasticity that propagates across multiple scales. A hybrid discrete-continuous stochastic-deterministic algorithm for simulation of the multiscale model based on the uniformization Monte Carlo method is implemented.
Dependence of optimal disturbances on periodic solution phases for time-delay systems
Authors: Khristichenko Michael Yu. , Nechepurenko Yuri M. , Bocharov Gennady A. 
Published: April 2023

Abstract
The paper is focused on the dependence of optimal disturbances of stable periodic solutions of time-delay systems on phases of such solutions. The results of numerical experiments with the well-known model of the dynamics of infection caused by lymphocytic choriomeningitis virus are presented and discussed. A new more efficient method for computing the optimal disturbances of periodic solutions is proposed and used.
Analisis Dinamik Model Predator-Prey pada Penyebaran Grass Carp Fish sebagai Biokontrol Populasi Eceng Gondok di Perairan Rawapening
Authors: Ilmiawan Dwi Fahmi , Carnawi Carnawi , Anwaristiawan Duwanda , Varantika Novanda , Anisa Rifki Dwi , Kharis Muhammad 
Published: April 2023

Eceng gondok merupakan tanaman invasif yang perlu dikontrol populasinya. Pengontrolan populasi eceng gondok dapat dilakukan dengan biokontrolgrass carp fishdan pemanenan. Interaksi pada pengontrolan tersebut dinamakan model predator-prey. Pada penelitian ini, dibahas sistem dinamik model predator-prey dan pengaruh penyebaran biokontrolpopulasi eceng gondok di Rawapening. Model yang dikontruksi dengan fungsi logistik dan respon Holling tipe III, karena sesuai dengan tipe ikan grass carp yang cenderung mencari mangsa lain ketika eceng gondok mulai berkurang. Keseimbangan kedua populasi terjadi pada titik dan dengan beberapa syarat batas. Keempat titik keseimbangan berada dalam kkondisi stabil dengan syarat tertentu pula. Pengaruh yang muncul di lapangan memberikan hasil yang positif. Di mana keberadaan ikan grass carp mampu menghambat pertumbuhan eceng gondok, meskipun belum terlihat secara signifikan. Nilai parameter yang diperoleh kemudian simulasikan melalui program Maple. Hasil simulasi numerik menunjukkan kedua populasi akan mencapai keseimbangan lestari dalam jangka waktu sekitar 600 hari. Ketika kehadiran burung predator turut diikutsertakan, model berubah cukup drastis.
Sintesis Nanopartikel Magnet Zn-Ferrite (Znfe2o4) Berbahan Dasar Pasir Besi Menggunakan Metode Kopresipitasi
Authors: Saputra Fandi Musthofa Ananda , Puspitarini Yani , Rizaldi Priyandika Dwi , Firdaus Muhammad Samsul Arifin , Sujarwata Sujarwata 
Published: April 2023

Pasir besi merupakan bahan baku alami yang keberadaannya terdistribusi secara merata dan luas di wilayah indonesia. Pemanfaatan pasir besi yang masih rendah di indonesia menyebabkan rendahnya harga jual dari material pasir besi. Maka, diperlukan sebuah teknologi dalam mengolah pasir besi agar menjadi sebuah produk yang memeliki daya guna. Material magnet ZnFe2O4 telah berhasil disintesis menggunakan metode kopresipitasi dengan bahan dasar pasir besi dari pantai Bayuran, Jepara, Jawa Tengah. Preparasi sampel ZnFe2O4 menggunakan campuran larutan ferric chloride dan zinc chloride yang diaduk dalam suhu ruang dan diperoleh endapan berwarna hitam. Hasil endapan dipanaskan dalam furnace dengan variasi suhu 100, 300 dan 500 °C. Bahan baku sebelum preparasi ZnFe2O4 dan hasil reaksi setelah pemanasan dikarakterisasi menggunakan spektroskopi difraksi sinar-x (XRD. Hasil pola difraksi dari karakterisasi XRD pasir besi menunjukkan bahwa bahan dasar yang digunakan memiliki fasa magnetit (Fe3O4) dengan struktur kristal kubik. Variasi suhu pemanasan menghasilkan pola difraksi dengan puncak-puncak intensitas yang berbeda. Namun, memiliki satu kesamaan fasa, yaitu fasa zinc-ferrite dengan perkiraan ukuran kristalin 144,28 nm. Perbedaan suhu pemanasan menunjukkan kenaikan intensitas puncak fasa zinc-ferrite seiring dengan penambahan suhu pemanasan.
Hard Candy Dari Wortel dan Tomat dengan Tambahan Ekstrak Propolis Sebagai Penambah Nutrisi Untuk Mata Pada Waktu Kegiatan Daring
Authors: Hidayati Rahmanisa Nur 
Published: April 2023

Penghujung tahun 2020 Indonesia masih dilanda Covid-19 data sebaran terbaru menunjukan masih tingginya pasien Covid-19. Penerapan pembelajaran disaat pandemi Covid-19 dilakukan secara virtual. Â Pengguna platfrom pembelajaran online mau tidak mau harus dapat mengakses internet dengan menggunakan smartphone, laptop maupun personal computer. Lamanya menatap komputer ataupun smartphone memberikan efek mata lelah. Upaya yang sebelumnyaÂ dilakukan untuk mengurangi kelelahan mata akibat menatap terlalu lama menatap komputer ataupun smartphone yaitu dengan menambahkan screen protector, tetapi screen protector tidak dapat menjaga mata terus menerus sehingga diperlukan sebuah suplemen yang mampu memberikan nutrisi untuk mata agar tetap terjaga kesehatannya. Wortel dan tomat merupakan sumber makanan yang kaya akan vitamin A. Pembuatan permen dari bahan dasar wortel sebagai solusi penambah vitamin A dengan menambahka tomat dan ekstra propolis produk permen ini tidak hanya penambah vitaminA tetapi dapat dijadikan sebagai permen kesehatan gigi.
Inter-religious Tolerance as Implementation of Pancasila at SMAN 15 Semarang
Authors: Dewani F. Sekar Hayu 
Published: April 2023

Pancasila Education is one of the subjects that must be delivered to all elements of society, especially for students. As a source of law in Indonesia, the Pancasila is the foundation that underlies all the regulations made. This means that all existing regulations in Indonesia must be in accordance with the noble values of Pancasila and must not contradict the Pancasila. As a rule of law every life of the nation and state must be based and guided by law. As is the case with the implementation of the first precepts written in the 1945 Constitution article 28 paragraph 1 and 2. As the basis of the Pancasila, it greatly influences the lives of all the people of Indonesia, especially in the first principle, namely the Almighty Godhead. On this occasion, I raised a title that was related to tolerance among diverse people in Semarang State High School 15. This data collection technique uses the observation method. Students in SMA Negeri 15 Semarang are pluralistic students, they come from a variety of different religious backgrounds, such as Islam, Catholicism, Christianity. There are certainly differences inherent in each of them. But the interactions that exist there do not show the differences that exist in themselves. All students in SMA Negeri 15 Semarang who always respect all differences are there. So that's why it can be seen the legal basis of Pancasila which is their guideline in carrying out the life of the nation and state.
Effect of the crystal structure and chemical bonding on the electronic and thermal transport in Cu2MeHf3S8 (Me – Mn, Fe, Co, Ni) thiospinels
Authors: Smitiukh Oleksandr , Soroka Oksana , Marchuk Oleg 
Published: April 2023

Establishing the relationship between crystal structure and transport properties is an important issue that is directly connected with the applicability of functional materials. In this work, we present the analysis of the crystal structure, chemical bonding, and electronic and thermal transport properties of Cu2МеHf3S8 (Ме – Mn, Fe, Co, Ni) compounds. The increase of weighted mobility in the Mn → Fe → Со → Ni series as well as the change of the dominant scattering mechanism of charge carriers from scattering on point defects to the scattering on acoustic phonons explains the best electronic transport in Cu2NiHf3S8. Moreover, bonding inhomogeneity between the covalent δ(Co – S) and δ(Hf – S) from one side, and more ionic δ(Cu – S) interactions from the other side leads to low lattice thermal conductivity in Cu2MeHf3S8 (Me – Mn, Fe, Co, Ni) materials. The work also suggests the link between the occupation of the octahedral 16d site and the thermoelectric performance of the investigated thiospinels. Particularly, the best thermoelectric performance is observed in the case of the presence of two valence electrons in the d-level of atoms in octahedral voids, which can be essential for further enhancement of the thermoelectric performance in thiospinels.
El pósito de Villaescusa de Haro (Cuenca) y su documento de donación de 1524
Authors: Sáez Olivares Alejandro 
Published: April 2023

El alhorí de trigo de Villaescusa de Haro es una de las construcciones que aparecen reseñadas desde antiguo en esta población, sin embargo, hasta ahora no se había concretado la fecha de su fundación y construcción. En el presente trabajo damos noticia del documento de donación firmado por el obispo Diego Ramírez de Villaescusa, en el cual se confirma la ordenación y erección del pósito durante el año 1524, constituyéndose, desde ese mismo momento, como institución benéfica a cargo del municipio.
La bibliografía sobre la regulación de estas instituciones en Castilla y la propia carta de donación nos permiten analizar el caso particular de este alhorí y la relación del donante con su localidad natal, convirtiéndose en uno de los ejemplos mejor documentados de este tipo de fundaciones particulares del primer tercio del siglo XVI.
Chemicals management approach to sustainable development of materials
Authors: Ogunseitan Oladele A. 
Published: April 2023

AbstractThroughout human history, the capacity to invent, manufacture, and use chemicals and materials has transformed concepts of development with path-dependent solutions to problems encountered in various industrial and societal sectors, including energy, transportation, food production, textiles, and personal care. It is increasingly clear that the trajectory of development initiated by some path-breaking materials is not sustainable. Recent developments in the concept of planetary boundaries have explored some reasons for unsustainability and ineffectiveness of current chemicals management practices. The reasons are almost always due to previously unknown chemical characteristics such as toxicity, reactivity, environmental recalcitrance, or increasing scarcity. In some cases, the suspected but ignored potential hazard of chemicals manifests slowly or becomes uncontrollable due to accumulation and biochemical or physical transformation in the environment. Consequently, environmental pollution by such chemicals is associated with alarmingly high levels of human mortality and disease burden worldwide. Recent examples include halogenated chemicals used as flame retardants and the thinning of the stratospheric ozone layer; bisphenol A used in plastics and microplastics widespread in biotic and abiotic ecosystem components, including the ocean; hormone mimicking chemicals such as phthalates in human tissues; neurotoxicity of lead used in solder materials, paints, and water distribution pipes; neurodevelopmental diseases associated with mercury used in ore beneficiation, in dental amalgams and lighting systems; and asbestos fibers used in ceiling tiles, roofs, and automobile brakes. These notorious examples have forced the introduction of retroactive policies to restrict the use of certain chemicals in materials development, and a few proactive policies designed to prevent the initial use of certain chemicals known or suspected to be hazardous. Improvements in the scientific knowledge and development of tools to screen for chemicals of concern have also led to the development of forecasting tools for improved management of chemicals. It could be impossible to foresee all potential risks associated with chemicals. Therefore, such management approaches can be most effective in supporting sustainable development of materials when they generate boundaries within which criteria for safety are understood and alternative assessments are continuous. This article situates the power of selected forecasting tools for early warning systems in a planetary boundary framework while highlighting gaps and incongruencies inherent in their use to support proactive and reactive regulatory policies, and for developing performance standards for lowering the chemical footprint of consumer products.
Graphical Abstract
Biomarkers of inflammation and endothelial dysfunction in elderly patients with myocardial infarction, hypertension and frailty
Authors: Agarkov N. M. , Okhotnikov O. I. , Golikov A. V. , Kolpina L. V. , Kolomiets V. I. 
Published: April 2023

Aim. To analyze the level of biomarkers of inflammation and endothelial dysfunction in elderly patients with myocardial infarction (MI), hypertension (HTN) and frailty.Material and methods. Three following clinical groups were formed: patients aged 60-74 years with MI+ grade 1-2 HTN (n=80); patients aged 60-74 with MI+HTN+prefrailty (n=52); patients aged 60-74 years with MI+HTN+frailty (n=114). In patients of all groups 2-4 months after MI, the levels of high-sensitivity C-reactive protein (hsCRP), intercellular adhesion molecule 1 (ICAM-1), nitric oxide (NO) metabolites — nitrates and nitrites, endothelin-1, desquamated endotheliocytes, vascular endothelial growth factor (VEGF) were determined.Results. Patients with MI+HTN+frailty had a higher hsCRP — 6,4 mg/l compared with patients with MI+HTN+ prefrailty (4,2 mg/l; p<0,01) and patients with MI+HTN (3,2 mg/l; p<0,01). The level of ICAM-1 was 315,6, 242,7, and 213,5 ng/ml, respectively, in these groups (p<0,01). Patients with MI+HTN+prefrailty, MI+HTN+frailty and MI+HTN had following levels of nitrite (NO2-) and nitrate (NO3-) — 6,7, 5,4, and 7,2 pmol/l (p<0,01). A similar ratio is inherent in NO3-. On the contrary, the content of desquamated endotheliocytes and VEGF was significantly higher in patients with MI+HTN+frailty compared with patients with MI+HTN+ prefrailty (p<0,01). The level of endothelin-1 was also significantly higher in patients with MI+HTN+frailty compared with the MI+HTN+prefrailty group: 18,85 vs 13,41 fmol/l (p<0,05).Conclusion. The levels of inflammation and endothelial dysfunction in patients with MI+HTN are significantly higher than those in patients with MI+HTN+frailty compared with patients with MI+AH+prefrailty and MI+HTN, with the exception of nitric oxide metabolites.
Hubungan Antara Kecerdasan Emosional dan Academic Burnout dengan Prestasi Belajar Siswa SMPN 2 Pakis Kabupaten Malang
Authors: Kirana Aulia Widya , Flurentin Elia , Setiyowati Arbin Janu 
Published: April 2023

Abstract: The purpose of this study was to determine the relationship between emotional intelligence and academic burnout with learning achievement. This study used correlational research design. The total population of class VIII students of SMP Negeri 2 Pakis is 156 students, the sample is 112 students obtained by the slovin formula with a 5 percent allowance. Sampling using simple random sampling method. Data collection used the emotional intelligence scale adapted by Bantolo (2020), and the academic burnout scale "MBI-SS" adapted by Maharani (2017). Both have been tested for validity and reliability. Measurement of learning achievement used odd mid-term semester scores 2022/2023. The results of this study are that there is no significant relationship between emotional intelligence and academic burnout with learning achievement. The variables of emotional intelligence and academic burnout only contribute 2.8 percent to learning achievement. While the other 97.2 percent is influenced by other factors or variables that are not measured in this study.
Abstrak: Penelitian ini bertujuan untuk mencari tau hubungan antara kecerdasan emosional dan academic burnout dengan prestasi belajar siswa. Rancangan penelitian yang digunakan yaitu kuantitatif non-eksperimen, dengan desain deskriptif korelasional. Total populasi siswa kelas VIII SMP Negeri 2 Pakis sebanyak 156 siswa, dengan jumlah sampel 112 siswa yang didapatkan dengan rumus slovin tingkat kelonggaran 5 persen. Dalam penentuan sampel, digunakan metode simple random sampling. Pengumpulan data melalui skala kecerdasan emosional mengadaptasi milik Bantolo (2020), dan skala academic burnout “Maslach Burnout Inventory-Student Survey (MBI-SS)” yang diadaptasi dari Maharani (2017). Keduanya telah melalui uji validitas dan uji reliabilitas. Pengukuran prestasi belajar menggunakan nilai UTS semester gasal 2022/2023. Hasil dari penelitian ini yaitu tidak terdapatnya hubungan yang signifikan antara kecerdasan emosional dan academic burnout dengan prestasi belajar. Variabel kecerdasan emosional, dan academic burnout hanya berkontribusi sebesar 2,8 persen dengan prestasi belajar. Sedangkan 97,2 persen lainnya dipengaruhi oleh faktor atau variabel lain yang tidak diukur pada penelitian ini.
Pengembangan Modul Perencanaan Karier untuk Meningkatkan Keterampilan Pengambilan Keputusan Karier Siswa SMP
Authors: Wibowo Suci Murni Prastiwi , Santoso Djoko Budi , Apriani Rizka 
Published: April 2023

Abstract: Research and development aims to produce a product out of a career planning module to enhance the middle-school career-making skills. Adapting the 5 steps of research and development of the Borg & Gall (1983) which covered (1) the stage of data collection; (2) research planning; (3) product design stage; (4) product trials; And (5) the product revision. The expert test consists of one materials expert, two media experts and two user candidates who are counselors. The analysis of the data results from the materials test uses the feasibility percentage formula, while the data of the media expert and the user test results use the inter-rater agremeent model formula. The results from a data analysis of materials collected by 90%. Validation from the media expert test scores by 1 as well as the user test scores by 1. The results of data analysis from the product testing process fall into very precise category, and thus the product that has been developed may be stated to meet the appropriate criteria for acceptance that include the four aspects of accuracy, usefulness, ease and attraction.
Abstrak: Penelitian dan pengembangan bertujuan menghasilkan produk berupa modul perencanaan karier untuk meningkatkan keterampilan pengambilan keputusan karier siswa SMP. Mengadaptasi 5 langkah penelitian dan pengembangan dari Borg & Gall (1983) yang meliputi (1) tahap pengumpulan data; (2) perencanaan penelitian; (3) tahap desain produk; (4) uji coba produk; dan (5) revisi produk.Uji ahli terdiri satu ahli materi, dua ahli media dan dua calon pengguna yang merupakan konselor. Analisis data hasil uji ahli materi menggunakan rumus presentase kelayakan, sedangkan data hasil uji ahli media dan uji calon pengguna menggunakan rumus inter-rater agremeent model. Dari hasil analisi data uji ahli materi diperoleh hasil sebesar 90%. Hasil validasi dari uji ahli media memperoleh skor sebesar 1 begitu pula dengan hasil uji calon pengguna memperoleh skor sebesar 1. Hasil analisis data dari proses uji coba produk tergolong dalam kategori sangat tepat, dengan demikian produk yang telah dikembangkan dapat dinyatakan sesuai dengan kriteria keberterimaan yang mencakup empat aspek yakni ketepatan, kegunaan, kemudahan dan kemenarikan.