bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart Tourism y Patrimonio Literario: Los casos de Edimburgo y Barcelona
Authors: Arcos Pumarola Jordi , Coma Quintana Laia , Conill Tetua Marta 
Published: March 2023

El presente artículo se propone evaluar las posibilidades que surgen de la creación de productos basados en la tecnología móvil para la interpretación del patrimonio literario en destinos turísticos. Para ello se realiza, a modo de estado de la cuestión, una investigación sobre las aplicaciones móviles dedicadas al patrimonio literario en Edimburgo, destino turístico-literario consolidado. Las conclusiones de este primer análisis, junto con la consideración de los principios del movimiento: Ciudades Educadoras, permiten valorar, desde una perspectiva socio-educativa y turística, la viabilidad y oportunidades que surgen de la creación de estos productosen el contexto de la ciudad de Barcelona.
Treponema pallidum subsp. pallidum with an Artificially impaired TprK antigenic variation system is attenuated in the Rabbit model of syphilis
Authors: Romeis Emily , Lieberman Nicole A. P. , Molini Barbara , Tantalo Lauren C. , Chung Benjamin , Phung Quynh , Avendaño Carlos , Vorobieva Anastassia , Greninger Alexander L. , Giacani Lorenzo 
Published: March 2023

Background
The TprK protein of the syphilis agent, Treponema pallidum subsp. pallidum (T. pallidum), undergoes antigenic variation in seven discrete variable (V) regions via non-reciprocal segmental gene conversion. These recombination events transfer information from a repertoire of 53 silent chromosomal donor cassettes (DCs) into the single tprK expression site to continually generate TprK variants. Several lines of research developed over the last two decades support the theory that this mechanism is central to T. pallidum’s ability for immune avoidance and persistence in the host. Structural and modeling data, for example, identify TprK as an integral outer membrane porin with the V regions exposed on the pathogen’s surface. Furthermore, infection-induced antibodies preferentially target the V regions rather than the predicted β-barrel scaffolding, and sequence variation abrogates the binding of antibodies elicited by antigenically different V regions. Here, we engineered a T. pallidum strain to impair its ability to vary TprK and assessed its virulence in the rabbit model of syphilis.

Principal findings
A suicide vector was transformed into the wild-type (WT) SS14 T. pallidum isolate to eliminate 96% of its tprK DCs. The resulting SS14-DCKO strain exhibited an in vitro growth rate identical to the untransformed strain, supporting that the elimination of the DCs did not affect strain viability in absence of immune pressure. In rabbits injected intradermally with the SS14-DCKO strain, generation of new TprK sequences was impaired, and the animals developed attenuated lesions with a significantly reduced treponemal burden compared to control animals. During infection, clearance of V region variants originally in the inoculum mirrored the generation of antibodies to these variants, although no new variants were generated in the SS14-DCKO strain to overcome immune pressure. Naïve rabbits that received lymph node extracts from animals infected with the SS14-DCKO strain remained uninfected.

Conclusion
These data further support the critical role of TprK in T. pallidum virulence and persistence during infection.
Prevalence of Minimal Hepatic Encephalopathy in Patients With Liver Cirrhosis: A Multicenter Study
Authors: Gairing Simon Johannes , Mangini Chiara , Zarantonello Lisa , Gioia Stefania , Nielsen Elise Jonasson , Danneberg Sven , Gabriel Maria , Ehrenbauer Alena F. , Bloom Patricia P. , Ripoll Cristina , Sultanik Philippe , Galle Peter Robert , Labenz Joachim , Thabut Dominique , Zipprich Alexander , Lok Anna S. , Weissenborn Karin , Marquardt Jens Uwe , Lauridsen Mette Munk , Nardelli Silvia , Montagnese Sara , Labenz Christian 
Published: March 2023

INTRODUCTION:The prevalence of minimal hepatic encephalopathy (MHE), in particular in different subgroups, remains unknown. This study aimed to analyze the prevalence of MHE in different subgroups to identify patients at high risk and to pave the way for personalized screening approaches.METHODS:In this study, data of patients recruited at 10 centers across Europe and the United States were analyzed. Only patients without clinical signs of hepatic encephalopathy were included. MHE was detected using the Psychometric Hepatic Encephalopathy Score (PHES, cut-off < or ≤−4 depending on local norms). Clinical and demographic characteristics of the patients were assessed and analyzed.RESULTS:In total, 1,868 patients with cirrhosis with a median model for end-stage liver disease (MELD) of 11 were analyzed (Child-Pugh [CP] stages: A 46%, B 42%, and C 12%). In the total cohort, MHE was detected by PHES in 650 patients (35%). After excluding patients with a history of overt hepatic encephalopathy, the prevalence of MHE was 29%. In subgroup analyses, the prevalence of MHE in patients with CP A was low (25%), whereas it was high in CP B or C (42% and 52%). In patients with a MELD score <10, the prevalence of MHE was only 25%, but it was 48% in patients with a MELD score ≥20. Standardized ammonia levels (ammonia level/upper limit of normal of each center) correlated significantly, albeit weakly with PHES (Spearman ρ = −0.16,P< 0.001).DISCUSSION:The prevalence of MHE in patients with cirrhosis was high but varied substantially between diseases stages. These data may pave the way for more individualized MHE screening approaches.
Electronic Health Record Burden Among Gastroenterology Providers Associated With Subspecialty and Training
Authors: Bali Aman S. , Hashash Jana G. , Picco Michael F. , Kinnucan Jami A. , Farraye Francis A. 
Published: March 2023

INTRODUCTION:
Use of the electronic health record (EHR) has become increasingly widespread. Higher EHR burden is associated with burnout, but this has not been specifically investigated among gastroenterology (GI) providers.

METHODS:
We retrospectively collected measures of EHR use for outpatient GI providers during a 6-month period. We compared metrics across provider sex, subspecialty, and training (physicians vs nonphysician providers [NPPs]).

RESULTS:
Data collected represented more than 16,000 appointments from 41 providers across the Division of Gastroenterology and Hepatology. Inflammatory bowel disease (IBD) and hepatology specialists spent more time per appointment in the EHR, clinical review, and outside regular hours compared with other subspecialists. NPPs spent more EHR time than physicians.

DISCUSSION:
IBD and hepatology specialists and NPPs may have disproportionally high EHR burden. More work is needed to understand differences in provider workload to combat burnout.
Past and future freshwater availability scenarios and their impact on the Indian Sundarbans ecosystem and fisheries
Authors: Das Lalu , Bhowmick Sayani , Goswami Purba , Choudhury Ratul Roy , Akhter Javed 
Published: March 2023

Abstract
The Indian Sundarbans are considered one of the zones of highest vulnerability in the world in terms of climate change. About 4.43 million people living in the Indian Sundarbans face a lack of freshwater availability due to the erratic behaviour of monsoon rains, frequent cyclonic storms, intrusion of saline water, and other factors, all of which affect the fisheries and agriculture activities of this area. In this study, estimates of freshwater availability through past and predicted future rainfall and evapotranspiration change scenarios in the Sundarbans are presented. Due to the lack of high-quality in situ data, various sources of gridded rainfall and evapotranspiration data were used. Between 1948 and 2010, half of the 19 administrative blocks showed a decreasing trend of monsoonal rainfall while the rest showed an increasing trend. Freshwater availability showed a decreasing trend during the monsoon season over different blocks of the Sundarbans, which is a matter of great concern for fisheries and agricultural activities. Statistical downscaling was used to generate future rainfall and evapotranspiration scenarios, using coarse resolution Global Climate Models from the Coupled Model Inter-comparison Project, Phase Five for a smaller area like the Sundarbans. Downscaled global climate models project an increasing trend in future monsoon rainfall in both RCP 4.5 and RCP 8.5 emission scenarios. The increasing rainfall can trigger excessive run-off and flooding, which would in turn affect aquaculture infrastructure and damage lentic aquaculture productions across the Sundarbans. However, increased rainfall may expand the flood plain area and extend the feeding grounds of fish. Hence, the impact of rainfall change is quite unpredictable. Proper adaptation techniques may be required to harness the positive impacts while preventing negative effects.
Design, optimization and economic viability of an industrial low temperature hot water production system in Algeria: A case study
Authors: Kaci Karim , Merzouk Mustapha , Merzouk Nachida Kasbadji , Missoum Mohammed , El Ganaoui Mohammed , Behar Omar , Djedjig Rabah 
Published: March 2023

Solar energy has a great potential in many areas of industrial activity in Algeria. This is because most of Algeria has high levels of sustainable solar insulation. Unfortunately, few industries use solar energy for hot water generation, but some industrial processes require hot water at temperatures that can be easily obtained from solar thermal panels. This paper presents a case study to investigate the technical and financial feasibility of a solar-powered industrial agro-processing system in Algiers. Based on the solar collectors connection type for which the economic feasibility study was carried out, an appropriate design of the system was determined. The latter was actually done by analyzing the levelized cost of energy savings. The design of the thermo-solar process is carried out based on F-chart method with a new approach by integrating the incidence angle modifier and of using real and experimental data requirements to determine realistic achievable performance of the solar process. The results showed that, in comparison to the currently used electrical system, the electrical energy savings achieved by the solar-powered system make it an economically viable option with a solar coverage rate of 80%. The investment depreciation balance shows that the use of such a thermal solar energy system will be more competitive than fossil fuels system if the price of electricity in the country increases from 0.048 to 0.075 €/kWh.
Measuring Communication Quality of Interest Rate Announcements
Authors: Benchimol Jonathan , Caspi Itamar , Kazinnik Sophia 
Published: March 2023

Abstract
We use text-mining techniques to measure the accessibility and quality of information within the texts of interest rate announcements published by the Bank of Israel over the past decade. We find that comprehension of interest rate announcements published by the Bank of Israel requires fewer years of education than interest rate announcements published by the Federal Reserve and the European Central Bank. In addition, we show that the sentiment within these announcements is aligned with economic fluctuations. We also find that textual uncertainty is correlated with the volatility of the domestic financial market.
Bombax ceiba Linn. leaf extract rich in phenolic compounds to mitigate non-alcoholic fatty liver-related complications in experimental model
Authors: El-Bana Mona A. , Ashour Magdi N. , Rasheed Wafaa I. , Diab Yasser M. , Medhat Dalia 
Published: March 2023

Abstract

Objectives
Obesity, diabetes mellitus, insulin resistance (IR), and hypertriglyceridemia are common features observed in non-alcoholic fatty liver diseases (NAFLD). There is a critical medical necessity to find novel therapeutics that can halt the development of NAFLD.

Methods

Bombax ceiba Linn. leaf extract was prepared and its phytochemical profile was determined. Standard and high carbohydrate high-fat diets (HCHF) were prepared. Rats were fed HCHF for 18 weeks to induce a non-alcoholic fatty liver (NAFL) model. Forty male rats were divided into control, B. ceiba Linn. leaf extract, NAFL, prophylactic, and treated groups. Serum fasting blood sugar (FBS), insulin, insulin resistance (HOMA-IR), cholesterol, high-density lipoprotein (HDL), triglycerides (TG), low density lipoprotein (LDL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), intelectin-1 (ITLN1), p38 MAP kinase (MAPK), peroxisome proliferator-activated receptor alpha (PPAR-α), and interleukin-6 (IL-6) were evaluated.

Results
Data obtained showed that HCHF-induced NAFL resulting in a significant increase in FBS, serum insulin, HOMA-IR, cholesterol, LDL, TG, ALT, AST, and IL-6 and a significant decrease in serum levels of HDL, ITLN1, p38 MAP kinase, and PPAR-α compared to the control group. The analysis of B. ceiba Linn. leaf extract showed high content of phenol compounds which may cause a significant decrease in the levels of FBS, insulin, HOMA-IR values, lipid profile, and levels of IL-6 while a significant increase in serum levels of LDL, ITLN1, p38 MAP kinase, and PPAR-α compared to the NAFL group.

Conclusions

B. ceiba Linn. Leaf extract is a highly protective and promising therapeutic agent against inflammation and oxidative stress in the NAFLD model induced by HCHF.
On limits of betweenness relations
Authors: Bradley-Williams David , Truss John K. 
Published: March 2023

AbstractWe give a flexible method for constructing a wide variety of limits of betweenness relations. This unifies work of Adeleke, who constructed a Jordan group preserving a limit of betweenness relations, and Bhattacharjee and Macpherson who gave an alternative method using a Fraïssé-type construction. A key ingredient in their work is the notion of a tree of 𝐵-sets. We employ this and extend its use to a wider class of examples.
Crystal structure of 5-(adamantan-1-yl)-3-[(4-{[2-(trifluoromethyl)phenyl]-methyl}piperazin-1-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione, C25H31F3N4OS
Authors: Al-Wahaibi Lamya H. , Abdelbaky Mohammed S. M. , Garcia-Granda Santiago , Tiekink Edward R. T. , El-Emam Ali A. 
Published: March 2023

Abstract
C25H31F3N4OS, monoclinic, P21/c (no. 14), a = 6.7323(1) Å, b = 15.4999(2) Å, c = 23.7905(4) Å, β = 93.037(2)°, V = 2479.05(6) Å3, Z = 4, R
gt(F) = 0.0473, wR
ref(F
2) = 0.1394, T = 293 K.
Affektivität und Hermeneutik der Macht. Ein Kommentar zum Aphorismus 13 derFröhlichen Wissenschaft
Authors: Simonin David 
Published: March 2023

AbstractAffectivity and the Hermeneutics of Power: A Commentary on Aphorism 13 ofThe Gay Science.Section 13 ofThe Gay Scienceis devoted to the doctrine of the feeling of power, which recapitulates Nietzsche’s main ideas of the previous years and already presents them in the form of a doctrine that does not yet bear the name “will to power.” Hence, GS 13 is a turning point in the development of Nietzsche’s philosophy of power, which, from the perspective of feeling, points to two essential components of all power: affect and hermeneutics. This article retraces the structure of the section and the main features of the feeling of power with special attention to the progression of the first twelve sections. It provides a better understanding ofThe Gay Scienceand of Nietzsche’s philosophy of power by paying due consideration to a severely underestimated concept, which most commentators have reduced to a mere psychological and draft version of the famous later concept of “will to power.” Although the purpose of this article is not to confront both formulations, some analyses (e. g., on vanity, sacrifice, hedonism, on the continuity and complementarity of strong and weak natures as well as of their moralities) will prove useful to gain a better insight into Nietzsche’s overall conception of power.
Effect of solvent inclusion on the structures and solid-state fluorescence of coordination compounds of naphthalimide derivatives and metal halides
Authors: Beebeejaun-Boodoo B. M. Parveen , Rademeyer Melanie 
Published: March 2023

Abstract
The structural characteristics and solid-state fluorescence of coordination compounds formed between the fluorophore N-((3-pyridyl)methyl)-1,8-naphthalimide (3-pn) and a range of divalent metal halides, were investigated. Six new crystal structures, of the formula ML
2
X
2.solv, were obtained through the combination of the organic ligand L = 3-pn with the divalent metal halides CoX2 (X = Cl− or Br−) or ZnX2 (X = Cl− or Br−) in different solvents. It was found that solvent molecules are incorporated into all the structures, and that the same complex can incorporate different solvent molecules. The conformation of the complex molecule is determined by the solvent molecule incorporated into the structure. The fluorescence intensity is affected by the identity of the metal and halido ligand in the complex molecule, while the identity of the solvent molecule and the metal ion affects the emission wavelength. Thus, the solvent of crystallisation impacts on the solid-state fluorescence of the compounds, hence the same complex can be made to fluoresce at different wavelengths depending on the solvent of crystallisation.
Increasing the Resistance of Archival Cardboards against Thermal Destruction
Authors: Nováková Martina , Ďurovič Michal , Karl Jan 
Published: March 2023

Abstract
Valuable books and archival documents are stored in protective packaging, most frequently made of cardboard, in the depositories of archives, libraries, museums or galleries. As part of preventive conservation, the cardboard could theoretically be treated during production with suitable substances delaying ignition or decelerating flaming combustion. This work describes a study of the short-term and long-term effectiveness of selected inorganic additive flame retardants and their influence on the properties of cardboards. Substances containing silicon, boron or hydroxide anions were tested on Prolux solid cardboard and Klug corrugated cardboard. Parameters such as the linear burning rate, oxygen index, heat release rate, weight loss during heating, pH of an aqueous extract, and total colour difference were evaluated. A mixture of mica and bentonite Cloisite-Na+ in a solution of Tylose MH6000 was found to be most useful for this purpose. This mixture doubled the time to ignition of Klug cardboard; in measurements of the linear burning rate, it caused early flame self-extinction for both kinds of cardboard and, simultaneously, had no observable detrimental effect on the stability of the treated cardboard.
Spontaneous self-affirmation: an adaptive coping strategy for people with chronic pain
Authors: You Dokyoung S. , Hettie Gabrielle , Darnall Beth D. , Ziadni Maisa S. 
Published: March 2023

Abstract

Objectives
Self-affirmation may be a promising treatment strategy for improving clinical outcomes. This study examined the association between self-affirmation and self-reported health status among people with chronic pain.

Methods
In this cross-sectional study, 768 treatment seeking people (female 67.2%, mean age=50.4 years with SD of 17.1, White/Caucasian 59.9%) completed surveys using a learning healthcare system. Measures included spontaneous self-affirmation (SSA) items, PROMIS® outcome measures, and Pain Catastrophizing Scale (PCS). Multiple regressions were conducted to examine if strength-based SSA, value-based SSA, and their interaction would predict perceived health status and pain coping strategy. Sensitivity analysis was done by performing additional regressions with covariates (age, sex, race/ethnicity, and education). Lastly, exploratory analysis examined if average SSA scores would have a linear relationship with perceived health status.

Results
The strength x value-based SSA interaction significantly predicted the PROMIS-depression, anxiety, and social isolation T-scores (ps≤0.007), but not anger T-scores (p=0.067). Specifically, greater tendency to use both SSA styles predicted less symptoms of depression, anxiety and social isolation. This interaction remained significant when controlling for the covariates. The two SSA styles and their interaction did not significantly predict pain interference, sleep disturbance, fatigue, average pain rating and PCS scores (ps≥0.054). Exploratory analysis revealed SSA average scores did not have a significant linear relationship with perceived health status.

Conclusions
The current study showed self-affirmation as being associated with better psychosocial health, but not associated with physical health and pain catastrophizing among patients with chronic pain. Our findings suggested the potential benefit of incorporating strength- and value-based affirmations in pain intervention approaches.
Shapes of the noncentrosymmetric TeO5E groups in tellurite glasses with P2O5 additions
Authors: Hoppe Uwe 
Published: March 2023

Abstract
The noncentrosymmetric shapes of the TeO
n
E units (n = 3, 4, and 5) are important for the nonlinear optical properties of the tellurite glasses (E – lone pair). An earlier diffraction work on the binary (TeO2)1−x
(P2O5)
x
glasses reported Te−O coordination numbers larger than four, which means the rare case of proportions of TeO5E units. The distributions of the Te−O distances in these glasses differ from those known in the related crystal structures. The so far unknown shapes of the TeO5E units are determined by the use of a mechanical analog. Five steel balls can move freely in a spherical bowl. Under the effect of gravity, they take a structure that is equivalent to that of the five oxygen ligands of a TeO5E unit. The average bond lengths of the TeO5E groups obtained for the glasses differ a little from the lengths of this unit. The small differences are attributable to variations based on the uneven tensions caused by the network disorder. The mechanical analog was set up on basis of the present conceptions of the lone pair’s steric effects. The ratio of the ball’s and bowl’s diameters is taken from published analyses of crystal structures.
A quantitative fluorescence‐based approach to study mitochondrial protein import
Authors: Jain Naintara , Gomkale Ridhima , Bernhard Olaf , Rehling Peter , Cruz‐Zaragoza Luis Daniel 
Published: March 2023

AbstractMitochondria play central roles in cellular energy production and metabolism. Most proteins required to carry out these functions are synthesized in the cytosol and imported into mitochondria. A growing number of metabolic disorders arising from mitochondrial dysfunction can be traced to errors in mitochondrial protein import. The mechanisms underlying the import of precursor proteins are commonly studied using radioactively labeled precursor proteins imported into purified mitochondria. Here, we establish a fluorescence‐based import assay to analyze protein import into mitochondria. We show that fluorescently labeled precursors enable import analysis with similar sensitivity to those using radioactive precursors, yet they provide the advantage of quantifying import with picomole resolution. We adapted the import assay to a 96‐well plate format allowing for fast analysis in a screening‐compatible format. Moreover, we show that fluorescently labeled precursors can be used to monitor the assembly of the F1F0 ATP synthase in purified mitochondria. Thus, we provide a sensitive fluorescence‐based import assay that enables quantitative and fast import analysis.