bluuebunny/crossref_metadata_2025_split huggingface dataset:
Der Übersetzungsprozess des chinesischenzaju-StückesDer Kreidekreisin Deutschland
Authors: Beilei Rao 
Published: July 2023

ZusammenfassungDie Adaption des chinesischenzaju-StückesDer Kreidekreiserreicht im 20. Jahrhundert in Deutschland ihren Höhepunkt. Allerdings wird der Übersetzungsprozess als entscheidende Voraussetzung für die weltweite Zirkulation dieses Stückes in früheren Untersuchungen wenig berücksichtigt. In diesem Zusammenhang liegt das Ziel des vorliegenden Beitrags darin, den Übersetzungsprozess desKreidekreis-Stückes in Deutschland mithilfe des Begriffs des ‚dritten Raums‘ von Homi Bhabha zu rekonstruieren, damit die unterschiedlichen Übersetzungsstrategien der Übersetzer und die Interpretationsmöglichkeiten der kulturspezifischen Elemente im chinesischen Original dargestellt werden können. Außerdem ist zu betrachten, wie der Sinologe Alfred Forke auf der Grundlage vorangegangener Übersetzungsversionen dasKreidekreis-Stück inhaltlich wortgetreu wie auch strukturell metrisch ins Deutsche überträgt, wobei die kulturellen Differenzen des chinesischen Originals weitgehend beibehalten werden.
Comprehensive analysis of macrosomia: exploring the association between first-trimester alanine aminotransferase and uric acid measurements in pregnant women
Authors: Arslanca Seyma Banu , Caglar Ali Turhan 
Published: July 2023

Abstract

Objectives
Investigating the relationship between liver enzymes, uric acid (UA), and macrosomia will benefit physicians in the early detection of complications that may emerge during/after pregnancy. The study analyzed liver enzyme activity and UA levels in first-trimester pregnant for the risk of macrosomia.

Methods
This retrospective cross-sectional research analyzed the data of pregnant women who gave birth between Jan 2021–2023. All data were extracted from medical records, and UA and AST-ALT were examined in all the participants.

Results
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were higher in the macrosomia (p<0.05). Similarly, UA levels were higher in the macrosomia (p<0.001). There was a moderate positive correlation between ALT and birth weight (r=0.168, p<0.01), while we found a strong positive correlation between UA and birth weight (r=0.355, p<0.01). In the ROC (receiver operating characteristic), Area Under the Curve (AUC) for ALT and UA was significant (p<0.0001) but not for AST (p=0.157). UA showed a predictive value for macrosomia with 68.1 % sensitivity and 63.8 % specificity at a 3.15 cut-off (AUC:0.689; p:0.0001; CI:0.644–0.725).

Conclusions
These results indicate that ALT and UA may be potentially important in determining the risk of macrosomia. The UA had a more potent marker for macrosomia than ALT. The occurrence of macrosomia might be more closely related to the mother’s metabolic syndrome rather than NAFLD.
Diagnostic accuracy of stool sample-based PCR in detecting Helicobacter pylori infection: a meta-analysis
Authors: Zhang Qinglong , Yang Shuang , Zhou Jianhua , Li Zhipeng , Wang Lili , Dong Quanjiang 
Published: July 2023

Abstract
The present study was to evaluate the diagnostic accuracy of different types of PCR tests with the aim of determining which one performs best for detecting Helicobacter pylori in stool samples. Related articles were searched from PubMed, Embase, Web of Science databases, Scopus, and Scholar Google. The quality of included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool and RevMan5.4 software. Pooled sensitivity, specificity, DOR, PLR and NLR for the stool PCR test in detecting H. pylori infection were performed by Stata 15.0 software. Subgroup meta-analysis was performed by Open Meta-analyst software. Ten studies were selected in this study. Stool PCR test had 92.0 % (83.0, 96.0 %) pooled sensitivity, 96.0 % (84.0, 99.0 %) pooled specificity, 296.0 (51.6, 1,696.9) pooled DOR, 26.1 (5.3, 128.7) pooled PLR and 0.09 (0.04, 0.18) NLR in the diagnosis of H. pylori infection, and summary receiver operating characteristic curve (SROC) illustrated an area under the curve (AUC) of 0.98. Subgroup meta-analysis showed rtPCR as having the highest diagnostic accuracy. Our results identify rtPCR as having the highest diagnostic accuracy for the detection of H. pylori in stool samples, and the stool PCR test as a reliable diagnostic tool for H. pylori infection.
lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation
Authors: Chen Wenming , Zhao Wei , Hao Minghui , Wang Yuping 
Published: July 2023

Abstract
UCA1 is predicted to bind to miR-132, which is a key player in the proliferation of vascular smooth muscle cells (VSMCs). This research studied the role of lncRNA UCA1 in atherosclerosis. The binding of UCA1 to miR-132 was proved by dual luciferase activity assay and RNA immunoprecipitation. UCA1 and miR-132 failed to affect each other’s expression in VSMCs. UCA1 was upregulated and miR-132 was decreased in atherosclerosis plasma. However, they are not closely correlated across atherosclerosis and control plasma sample. Interestingly, UCA1 suppressed the role of miR-132 in downregulating Lrrfip1 expression and promoting VSMC proliferation. Therefore, UCA1 is downregulated in atherosclerosis and may regulate miR-132/Lrrfip1 axis to promote VSMC proliferation.
Hsa-miR-223-3p participates in the process of anthracycline-induced cardiomyocyte damage by regulating NFIA gene
Authors: Han Xiao , Liu Kun , Gao Fumin , Yang Mingjun , Wang Fei 
Published: July 2023

Abstract
Irreversible cardiomyopathy was caused by the therapeutic of anthracyclines in the chemotherapy of cancers. The cell apoptosis and autophagy were induced by anthracyclines in AC16 cells. MiR-223-3p ascends in anthracycline-treated AC16, but the expression of nuclear factor I-A (NFIA) was specifically down-regulated. However, the underlying molecular mechanism between NFIA and miR-223-3p is unclear now in AC16 cells. In our research, NFIA expression was dampened in AC16 cells by miR-223-3p mimics. Additionally, miR-223-3p knockdown hindered the apoptosis and autophagy in anthracycline-treated AC16. Furthermore, NFIA was predicted and verified as a miR-223-3p’s downstream target and rescued the functions of miR-223-3p. These findings illustrated that miR-223-3p advances anthracycline-stimulated cardiomyocyte damage progression by targeting NFIA, implying the promising therapeutic function of miR-223-3p on cardiomyocyte damage in cancer patients.
Synapse-Specific Defects in Synaptic Transmission in the Cerebellum of W246G Mutant ELOVL4 Rats–a Model of Human SCA34
Authors: Nagaraja Raghavendra Y. , Stiles Megan A. , Sherry David M. , Agbaga Martin-Paul , Ahmad Mohiuddin 
Published: July 2023

Elongation of very long fatty acids-4 (ELOVL4) mediates biosynthesis of very long chain-fatty acids (VLC-FA; ≥28 carbons). Various mutations in this enzyme result in spinocerebellar ataxia-34 (SCA34). We generated a rat model of human SCA34 by knock-in of a naturally occurring c.736T>G, p.W246G mutation in theElovl4gene. Our previous analysis of homozygous W246G mutant ELOVL4 rats (MUT) revealed early-onset gait disturbance and impaired synaptic transmission and plasticity at parallel fiber-Purkinje cell (PF-PC) and climbing fiber-Purkinje cell (CF-PC) synapses. However, the underlying mechanisms that caused these defects remained unknown. Here, we report detailed patch-clamp recordings from Purkinje cells that identify impaired synaptic mechanisms. Our results show that miniature EPSC (mEPSC) frequency is reduced in MUT rats with no change in mEPSC amplitude, suggesting a presynaptic defect of excitatory synaptic transmission on Purkinje cells. We also find alterations in inhibitory synaptic transmission as miniature IPSC (mIPSC) frequency and amplitude are increased in MUT Purkinje cells. Paired-pulse ratio is reduced at PF-PC synapses but increased at CF-PC synapses in MUT rats, which along with results from high-frequency stimulation suggest opposite changes in the release probability at these two synapses. In contrast, we identify exaggerated persistence of EPSC amplitude at CF-PC and PF-PC synapses in MUT cerebellum, suggesting a larger readily releasable pool (RRP) at both synapses. Furthermore, the dendritic spine density is reduced in MUT Purkinje cells. Thus, our results uncover novel mechanisms of action of VLC-FA at cerebellar synapses, and elucidate the synaptic dysfunction underlying SCA34 pathology.SIGNIFICANCE STATEMENTVery long chain-fatty acids (VLC-FA) are an understudied class of fatty acids that are present in the brain. They are critical for brain function as their deficiency caused by mutations in elongation of very long fatty acids-4 (ELOVL4), the enzyme that mediates their biosynthesis, results in neurologic diseases including spinocerebellar ataxia-34 (SCA34), neuroichthyosis, and Stargardt-like macular dystrophy. In this study, we investigated the synaptic defects present in a rat model of SCA34 and identified defects in presynaptic neurotransmitter release and dendritic spine density at synapses in the cerebellum, a brain region involved in motor coordination. These results advance our understanding of the synaptic mechanisms regulated by VLC-FA and describe the synaptic dysfunction that leads to motor incoordination in SCA34.
FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1
Authors: Sun Xiaorui , Gao Congwen , Xu Xin , Li Mengyuan , Zhao Xinhua , Wang Yanan , Wang Yun , Zhang Shun , Yan Zhenzhen , Liu Xiuhua , Wu Chen 
Published: July 2023

AbstractFibrillarin (FBL) is a highly conserved nucleolar methyltransferase responsible for methylation of ribosomal RNA and proteins. Here, we reveal a role for FBL in DNA damage response and its impact on cancer proliferation and sensitivity to DNA‐damaging agents. FBL is highly expressed in various cancers and correlates with poor survival outcomes in cancer patients. Knockdown of FBL sensitizes tumor cells and xenografts to DNA crosslinking agents, and leads to homologous recombination‐mediated DNA repair defects. We identify Y‐box‐binding protein‐1 (YBX1) as a key interacting partner of FBL, and FBL increases the nuclear accumulation of YBX1 in response to DNA damage. We show that FBL promotes the expression of BRCA1 by increasing the binding of YBX1 to the BRCA1 promoter. Our study sheds light on the regulatory mechanism of FBL in tumorigenesis and DNA damage response, providing potential therapeutic targets to overcome chemoresistance in cancer.
A long non-coding RNA essential for early embryonic development improves somatic cell nuclear transfer somatic cell nuclear transfer efficiency in goats
Authors: Jin Miaomiao , Zhao Lu , Yang Hanwen , Zhao Jianglin , Ma Hongwei , Chen Yanzhi , Zhang Jingcheng , Luo Yan , Zhang Yong , Liu Jun 
Published: July 2023

In brief
Early embryonic development in goats is a complex and an important process. This study identified a novel long non-coding RNA (lncRNA), lncRNA3720, that appears to affect early embryonic development in goats through histone variants.

Abstract
Although abundant lncRNAs have been found to be highly expressed in early embryos, the functions and mechanisms of most lncRNAs in regulating embryonic development remain unclear. This study was conducted to identify the key lncRNAs during embryonic genome activation (EGA) for promoting embryonic development after somatic cell nuclear transfer (SCNT) in goats. We screened and characterized lncRNAs from transcriptome data of in vitro-fertilized, two-cell (IVF-2c) and eight-cell embryos (IVF-8c) and eight-cell SCNT embryos (SCNT-8c). We obtained 12 differentially expressed lncRNAs that were highly expressed in IVF-8c embryos compared to IVF-2c and less expressed in SCNT-8c embryos. After target gene prediction, expression verification, and functional deletion experiments, we found that the expression level of lncRNA3720 affected the early embryonic development in goats. We cloned full-length lncRNA3720 and over-expressed it in goat fetal fibroblasts (GFFs). We identified histone variants by analyzing the transcriptome data from both GFFs and embryos. Gene annotation of the gene library and the literature search revealed that histone variants may have important roles in early embryo development, so we selected them as the potential target genes for lncRNA3720. Lastly, we compensated for the low expression of lncRNA3720 in SCNT embryos by microinjection and showed that the development rate and quality of SCNT embryos were significantly improved. We speculate that lncRNA3720 is a key promoter of embryonic development in goats by interacting with histone variants.
Penyelesaian Perkara Melalui Restorative Justice oleh Penyidik Dalam Penanganan Tindak Pidana Penganiayaan
Authors: Akbar Sandi Riz , Rahman Abd , Wahab Mirnawati , Darmawansya TL Andi 
Published: July 2023

This study was conducted with the aim of knowing and analyzing the effectiveness of case resolution through restorative justice by investigators in handling criminal acts of persecution at the Raja Ampat Resort Police. And to know and analyze the factors that affect the effectiveness of case resolution through restorative justice by investigators in handling criminal acts of persecution at the Raja Ampat Resort Police. This study used primary data obtained directly in the field based on interviews conducted by researchers to investigators of the Raja Ampat Resort Police as many as 5 people. The Data were analyzed using qualitative analysis. The results of this study show that the resolution of cases through restorative justice by investigators in handling criminal acts of persecution at the Raja Ampat Resort Police is quite effective. The possibility of factors that influence the effectiveness of case resolution through restorative justice in criminal acts of persecution are internal factors and external factors. The most influential factor in this study is the culture or customs of the community.Keywords: Effectiveness; Criminal; Restorative Justice AbstrakPenelitian ini dilakukan dengan bertujuan untuk mengetahui dan menganalisis Efektivitas Penyelesaian Perkara Melalui Restorative Justice Oleh Penyidik Dalam Penanganan Tindak Pidana Penganiayaan Pada Kepolisian Resor Raja Ampat. Dan untuk mengetahui dan menganalisis faktor-faktor yang mempengaruhi Efektivitas Penyelesaian Perkara Melalui Restorative Justice Oleh Penyidik Dalam Penanganan Tindak Pidana Penganiayaan Pada Kepolisian Resor Raja Ampat. Penelitian ini menggunakan data primer yang diperoleh secara langsung di lapangan berdasarkan wawancara yang dilakukan peneliti kepada penyidik Kepolisian Resor Raja Ampat sebanyak 5 orang. Data dianalisis dengan menggunakan analisis kualitatif. Hasil penelitian ini menunjukkan bahwa penyelesaian perkara melalui restorative justice Oleh Penyidik Dalam Penanganan Tindak Pidana Penganiayaan Pada Kepolisian Resor Raja Ampat cukup efektif. Kemdudian faktor yang berpengaruh terhadap efektivitas penyelesaian perkara melalui restorative justice dalam tindak pidana penganiayaan adalah faktor internal dan faktor eksternal. Adapun faktor yang paling berpengaruh dalam penelitian ini adalah Budaya atau Adat masyarakat.Kata Kunci: Efektivitas; Tindak Pidana; Restorative Justice
Hapusnya Tanggung Jawab Terbatas Direksi Akibat Itikad Tidak Baik Dalam Penyaluran Kredit Fiktif Pada Perusahaan Daerah Bank Perkreditan Rakyat
Authors: Alam Faris Satria 
Published: July 2023

The directors who are given the responsibility to carry out the company and are fully responsible for managing the company for the benefit of the company. However, the directors have limited liability to the company in accordance with the principle of limit liability, but the principle of limit liability does not apply if the actions or actions of the directors are proven to have committed negligence and mistakes so that their actions are categorized as unlawful and result in losses to the company. The research method used is normative juridical qualitative research through a conceptual approach and a statutory approach. The results of the study stated that the elimination of the limited liability of the directors was due to bad faith in distributing fictitious loans to local people's credit banking companies. Meanwhile, the results of the study concluded that the principle of limit liability for directors would be erased if it could prove that the company's losses were not the result of negligence or mistakes.Keywords: Responsibility; Directors; Bad Faith; Fictitious Credit Abstrak:Direksi yang diberikan tanggung jawab untuk mengemban perusahaan dan bertanggung jawab penuh atas pengurusan perseroan demi kepentingan perseroan. Akan tetapi direksi memiliki batasan tanggung jawab terhadap perusahaan sesuai dengan prinsip limit liability, namun prinsip limit liability tidak berlaku jika saja perbuatan maupun tindakan direksi terbukti melakukan kelalaian dan kesalahan hingga perbuatanya dikategorikan sebagai tindakan melawan hukum dan mengakibatkan kerugian pada perusahaan. Metode penelitian yang digunakan adalah penelitian kualitatif yuridis normatif melalui pendekatan konseptual dan pendekatan peraturan perundang-undangan. Hasil penelitian menyatakan bahwa hapusnya tanggung jawab terbatas direksi akibat itikad tidak baik dalam penyaluran kredit fiktif pada perusahaan daerah bank pengkreditan rakyat. Sedangkan, hasil penelitian menyimpulkan bahwa prinsip limit liability direksi akan terhapus jika dapat membuktikan dimana kerugian perusahaan bukan akibat dari kelalaian atau kesalahannya.Kata Kunci: Tanggung Jawab; Direksi; Itikad Tidak Baik; Kredit Fiktif
Detection of carbapenem resistant Pseudomonas aeruginosa co-harboring blaVIM-2 and blaGES-5 in burn patients
Authors: Hmissi Souhir , Raddaoui Anis , Frigui Siwar , Abbassi Mohamed Salah , Achour Wafa , Chebbi Yosra , Thabet Lamia 
Published: July 2023

AbstractPseudomonas aeruginosa is one of the major infectious agents in burn patients. Globally, high rates of antimicrobial resistance in P. aeruginosa have been reported, which is a cause of concern. The objective of this study was to determine the rate of resistance to carbapenems in P. aeruginosa isolates recovered from burn patients in Tunisia, to search genes encoding for carbapenemases and to determine their epidemiological markers (serotypes). A retrospective study was conducted in the Burn Intensive Care Unit (BICU) of the Trauma and Burn Centre of Ben Arous, Tunisia, and P. aeruginosa isolates collected from burn patients, from January to December 2018 were investigated. Carbapenemase screening was performed by Carbapenem Inactivation Method (CIM) and by EDTA-disk test for all carbapenem resistant isolates. Genes encoding carbapenemases (blaVIM, blaIMP, blaGES, blaNDM, and blaKPC) were investigated by PCR and selected carbapenemase genes were sequenced. During the study period, 104 non duplicated P. aeruginosa isolates were recovered. Most of them were isolated from skin samples (45.1%) and blood culture (22.1%) and belonged to O:11 (19.2%), O:12, and O:5 (12.5%, each) serotypes. High rates of resistance were observed for carbapenems (64.4%). Among the 67 carbapenem resistant isolates, 58 (86.5%) harbored blaVIM gene and 55 (82%) blaGES gene; in addition, 48 (71.6%) co-harbored blaVIM and blaGES genes. After sequencing, the blaVIM-2 and blaGES-5 gene variants were identified in seven randomly selected isolates. To the best of our knowledge, this is the first description of P. aeruginosa simultaneously harboring blaVIM-2 and blaGES-5 genes.
THE INTERNATIONAL CRIMINAL COURT AND AFRICA: AN END TO ATROCITIES?
Authors: Lirieka Meintjes-Van der Walt  
Published: July 2023

Intentional killings, destruction and extermination of entire groups; widespread or systematic attack directed against civilians pursuant to state policy or that of other organisations; disregard for human rights; war crimes and acts of aggression, have ravaged the world in general and the continent of Africa in particular. The atrocities in Rwanda prompted UN Secretary-General Kofi Annan to conclude that “man’s capacity for evil knows no limits”. On 2 September 1998, the International Criminal Tribunal for Rwanda (ICTR) in The Prosecutor v Jean-Paul Akayesu (Case No CTR-9-4-T) found the accused guilty of genocide. The tribunal concluded that genocide was indeed committed in Rwanda in 1994 against the Tutsi as a group, and that the genocide appears to have been meticulously organised. Ethnic and religious tension continues to plague other parts of Africa, such as the Hutu/Tutsi conflict in Burundi and Christian/Muslim friction in Nigeria. Chad, Sudan, Uganda, Sierra Leone, Ivory Coast, the Democratic Republic of Congo (DRC) and the Central African Republic (CAR) have all been wracked with protracted civil wars.It is reported that the Congolese rebel leader Jeanne-Pierre Bemba is likely to be the first to be investigated for prosecution before the International Criminal Court.The situations in Angola and Liberia testify to atrocities which in international law can be classified as war crimes and crimes against humanity. According to a Business Day report Zimbabwean NGOs have threatened ICC action against the Zanu-PF elite.
The commission of grave atrocities on the continent has, however, not been limited to conflict situations. The terror under the rule of Amin and Obote of Uganda, Bokassa of the CAR, Habre of Chad, Mengistu of Ethiopia, Nguema of Equatorial Guinea, and Mobutu of the DRC illustrate that gross human rights violations in Africa have not necessarily only occurred during times of war.Also significant is the fact that the International Criminal Court (ICC) Statute includes apartheid (defined in a 7(2)(h) “as inhumane acts committed in the context of an institutionalised regime of systematic oppression and domination by one racial group over any other racial group or groups and committed with the intention of maintaining that regime”) as a category of crimes against humanity. In no other continent has the effect of apartheid been felt like in Africa. Until a little over a decade ago apartheid was institutionalised in South Africa.