bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of midwives in supporting the development of the mother-infant relationship: a scoping review
Authors: Stoodley Cathy , McKellar Lois , Ziaian Tahereh , Steen Mary , Fereday Jennifer , Gwilt Ian 
Published: March 2023

Abstract
Background
The mother-infant relationship is complex and dynamic, informing the psychological development of the infant through bonding and attachment. Positive early interactions influence the quality of this relationship. Midwives are well placed to support the developing relationship between the mother and baby, yet there has been limited research exploring the role of the midwife in this context.

Aim
To explore interventions that have been provided by the midwife which support the development of the maternal-fetal or mother-infant relationship amongst a low-risk population from pregnancy, and up to six weeks postnatal. The review also sought to understand the types of interventions developed, format and delivery, outcomes measured and if cultural considerations had been incorporated.

Methods
A scoping review of the research literature was undertaken using the Joanna Briggs Institute framework. Five online databases were searched for relevant articles published in English from 2000 to 2021.

Findings
Sixteen articles met the inclusion criteria. Three themes emerged: (1) viewing the fetus as separate from the mother, (2) focused activities on the maternal-infant relationship and (3) targeted educational interventions.

Discussion
Providing focused activities and targeted education during the pre and postnatal periods support the development of the mother-infant relationship. Significantly, there was insufficient research that considered the influence of culture in supporting the mother-infant relationship.

Conclusion
Further research is required to develop interventions that include a diverse sample to ensure culturally appropriate activities can be integrated into care during pregnancy and/or the postnatal period provided by midwives.
Toward an intentional model aware of learner cognitive traits for pedagogical process guidance
Authors: Bayounes Walid , Saâdi Ines Bayoudh , Kinshuk  
Published: March 2023

AbstractPrevious research on adaptive learning successfully demonstrated that use of Intentional Model for Educational Processes Guidance has gained popularity in Intelligent Tutoring System. Within this context, the novelty of this version of Intentional Model of Pedagogical Process Guidance (IMPPG) is the effectiveness use of Cognitive Trait Model to be aware of different traits of learner. The proposed model leads to generate an individualized learning for each learner by selecting the most appropriate pedagogical process according to the actual preferences of the tutor and the cognitive traits of learner. In fact, this model couples the pedagogical intention with the pedagogical strategies and provides a multitude of paths between learner intentions. Based on the cognitive traits of the individual learners and the corresponding pedagogical method or the individual teaching style, the ITS adopts the proposed model to adaptively support the tutor to achieve his/he intention through the selected strategy. This model has been experimented and assessed with tutors and students learning spreadsheet management in a first-year studying in applied license’s degree in Business English and applied license’s degree in Education. The first results show that the intentions and the strategies selected by our model were relevant according to students’ needs and tutors’ preferences. In the initial tests, the process model has met what was expected, however, more studies with experiments must be carried out. The primary results are reported and discussed in the paper; several lessons learned from the experience and potential improvements are also included.
Humeral trochlear morphology does not influence coronoid fractures in elbow dislocation
Authors: Arrigoni Paolo , Archinà Martina , Luceri Francesco , Radici Mattia , Zaolino Carlo , Folco Gianluca , Foschini Chiara , Regazzoni Simona , Miano Paul Muriithi , Zagarella Andrea , Colozza Alessandra , Randelli Pietro 
Published: March 2023

AbstractPurposeTraumatic elbow dislocation is the second most frequent joint dislocation, even though the elbow is a congruent and stable joint. Individual variability in anatomical congruence of the elbow and how it relates to simple or complex instability has rarely been studied in the literature; we hypothesized that a greater articular coverage by the humeral trochlea would be more likely to result in complex dislocation. The aim of this study is to analyze trochlear morphology in simple (SED) and complex elbow dislocation (CED), to assess whether the degree of humeroulnar joint congruence influences the incidence of coronoid fractures in elbow dislocation. The secondary goal is to evaluate the association between trochlear morphology and coronoid fracture pattern.MethodsAll the elbow CT scans of the hospital server were retrospectively analyzed. 62 patients were enrolled and so divided in 2 groups: SED and CED with isolated coronoid fracture. Patients who were skeletally immature, presented with other concomitant elbow fractures, or who previously underwent elbow surgery were excluded. The CT scans were performed after closed reduction and prior to further treatment. Coronoid fracture pattern was classified on CT scan according to Regan‐Morrey and O’Driscoll classifications; “grade 0” was assigned to SED. Trochlear coverage was measured and expressed as three angles (anterior, posterior, and distal) and their width/depth ratios. Measurements were taken by four different readers and the assessment was repeated after 15 days.ResultsNo statistically significant difference was found between humeral trochlear morphology of SED and CED patients. There was no association between morphometric measurements and coronoid fracture pattern. The results are strengthened by a good intra‐ and inter‐reader reproducibility of the CT analysis protocol.ConclusionsOur study is the first to evaluate the impact of trochlear morphology on elbow instability. Considering the results, other variables may have a greater impact on coronoid bone damage, such as trauma energy or ligamentous hyperlaxity: in particular, we believe that the capsuloligamentous structures of the elbow might contribute in a preponderant way to articular stability. The CT analysis protocol gave excellent results: reproducible, accurate and easy to perform.Level of evidenceIII.
The emergence of an imported variant of dengue virus serotype 2 in the Jazan region, southwestern Saudi Arabia
Authors: Dafalla Ommer , Abdulhaq Ahmed A. , Almutairi Hatim , Noureldin Elsiddig , Ghzwani Jaber , Mashi Omar , Shrwani Khalid J. , Hobani Yahya , Sufyani Ohood , Ayed Reem , Alamri Abdullah , Al-Mekhlafi Hesham M. , Eisa Zaki M. 
Published: March 2023

Abstract
Background
Dengue virus (DENV) infection is a global economic and public health concern, particularly in tropical and subtropical countries where it is endemic. Saudi Arabia has seen an increase in DENV infections, especially in the western and southwestern regions. This study aims to investigate the genetic variants of DENV-2 that were circulating during a serious outbreak in Jazan region in 2019.

Methods
A total of 482 serum samples collected during 2019 from Jazan region were tested with reverse transcription-polymerase chain reaction (RT-PCR) to detect and classify DENV; positive samples underwent sequencing and bioinformatics analyses.

Results
Out of 294 positive samples, type-specific RT-PCR identified 58.8% as DENV-2 but could not identify 41.2%. Based on sequencing and bioinformatics analyses, the samples tested PCR positive in the first round but PCR negative in the second round were found to be imported genetic variant of DENV-2. The identified DENV-2 imported variant showed similarities to DENV-2 sequences reported in Malaysia, Singapore, Korea and China. The results revealed the imported genetic variant of DENV-2 was circulating in Jazan region that was highly prevalent and it was likely a major factor in this outbreak.

Conclusions
The emergence of imported DENV variants is a serious challenge for the dengue fever surveillance and control programmes in endemic areas. Therefore, further investigations and continuous surveillance of existing and new viral strains in the region are warranted.
Venoarterial-extra corporeal membrane oxygenation-assisted parathyroidectomy for hypercalcemic crisis due to parathyroid carcinoma complicated by severe circulatory and respiratory failure: a case report
Authors: Enomoto Yuria , Matsuda Yuko , Nagamine Yusuke , Goto Takahisa 
Published: March 2023

Abstract
Background
Hypercalcemia crisis is a rare but severe form of hypercalcemia complicated by multiple organ failure. Hypercalcemia crisis due to hyperparathyroidism is commonly caused by a parathyroid tumor, which often requires surgical resection. However, there are no clear recommendations on when the surgery should be performed.

Case presentation
A 64-year-old female patient developed hyperparathyroidism due to a parathyroid tumor and hypercalcemic crisis, which was complicated by severe circulatory and respiratory failure refractory to medical therapy, and an emergent surgery was planned to resect the parathyroid tumor. To prevent intraoperative circulatory and respiratory collapse, venoarterial-extra corporeal membrane oxygenation (VA-ECMO) was introduced, resulting in a safe operation and anesthetic management.

Conclusions
In patients with hypercalcemic crisis complicated by severe circulatory and respiratory failure, induction of prophylactic VA-ECMO was useful for safe anesthetic management. Surgical resection should be performed as soon as the diagnosis is made before VA-ECMO is required.
Recent advancements in identification and detection of saliva as forensic evidence: a review
Authors: Upadhyay Megha , Shrivastava Pankaj , Verma Kapil , Joshi Bhawana 
Published: March 2023

AbstractBackgroundSaliva is the most common biological evidence found at any crime scene next to blood. It is a clear liquid which makes it immune to any possible evidence of alteration by the perpetrator. In forensics, saliva is used as biological evidence and is very helpful in determining various aspects of an individual such as sex, individuality, ABO blood groups, microbial signature, biomarkers, or habits like smoking.Main bodySaliva shares a great resemblance with plasma as it encompasses similar organic or inorganic compound contents. In forensic casework, identifying any evidence is the primary goal to establish the groundwork for further investigation. Saliva may be found in the form of a pool or stained form, but its identification is challenging because of its transparency. It has been widely used as an informative tool in forensic situations like poisoning, hanging, or cases of drug abuse, etc. for more than two decades now. Over the years, many proposed ways or methods have been identified and described, which helped in the detection and identification of saliva as evidence.ConclusionThis review article represents the significance of saliva as important forensic evidence, along with the different forms it may be encountered at the crime scene. The use of diverse collection and detection methods, over the past few decades, has been discussed. An attempt has been made to collect the available data, highlighting the merit and demerits of different identification techniques. The relevant data has been collected from all the published and reported literature (1987–2021).
Determinants of quality of life in Nigerian female patients with epilepsy on carbamazepine and levetiracetam monotherapy
Authors: Luqman Ogunjimi , Joseph Yaria , Akintomiwa Makanjuola , Akinyinka Alabi , Aderonke Aderinola , Bamidele Osalusi , David Oboh , Mojisola Olusola-Bello , Bolanle Falujo , Abdullahi Murtala , Olatunbosun Olawale , Fehintola Fatai , Adesola Ogunniyi 
Published: March 2023

AbstractBackgroundThe study is aimed to identify the predictors of Quality of Life (QOL) in women with epilepsy (WWE) on carbamazepine (CBM) and levetiracetam (LTM) monotherapy. 100 WWE were recruited (50 each on CBM and LTM), after clinical diagnosis of epilepsy supported by Electroencephalography (EEG) features and seizures classification by 2017 International League Against Epilepsy (ILAE) criteria, the Quality of Life Inventory Scale 31(QOLIE-31) and Zung Self-Rating Depression Scale (ZSRDS) were used to assess QOL and depression, respectively.ResultHigher QOLIE-31 scores was seen in the LTM group across all domains except seizure worry (p = 0.051) compared to CBM group.Logistic regression showed that the use of CBM (p = 0.000), fast frequency on EEG (p = 0.005), longer duration of epilepsy (p = 0.017), presence of depression (p = 0.008) and lower level of education (p = 0.003) were predictors of QOL. Progesterone (p = 0.040), oestradiol (p = 0.011) and prolactin (p = 0.002) in follicular phase showed significant association with QOLIE-total score. In the luteal phase, luteinizing hormone–follicle stimulating hormone (LH–FSH) ratio (p = 0.009) and testosterone (p = 0.015), FSH (p = 0.015), prolactin (p = 0.000), showed significant association with QOL. None of the hormones independently predicts QOL.ConclusionLTM group appears to have better QOL than CBM group. Healthcare providers should focus on addressing these identified predictors which include medication effect, depression, Level of education, EEG background and duration of epilepsy with aim of improving QOL.
Could thalamic biochemical changes correlate to cognitive impairment in idiopathic generalized epilepsy?
Authors: Daker Lamiaa I. , Sayed Sayed S. , Abdelghaffar Mohamed , Hamed Amany Hamdy , Aboelnor Mahmoud I. , El-Khatib Mohamed El-Sayed 
Published: March 2023

AbstractBackgroundThe thalamus is crucial in the development of idiopathic generalized epilepsy (IGE), which could lead to cognitive dysfunctions, according to data from neuropsychology and advanced neuroimaging investigations. This research aimed to measure the metabolic changes in the thalamus and to assess if could be contributed to cognitive impairment in IGE patients. Thirty IGE patients and thirty healthy volunteers with matched ages, genders, and educational levels participated in this cross-sectional case–control research. The IGE patients and controls were evaluated neuropsychologically using Intelligence Quotient (IQ) to assess general cognitive ability, Digit span for attention, Wechsler memory scale (WMS) for verbal memory, cube drawing test for visuospatial memory, Trail making test for executive functions, and Controlled Oral Word Association test (COWAT) for verbal fluency and quantitative multi-voxel MR spectroscopy (MRS) measurements ofN-acetyl aspartate (NAA), choline (Cho), creatine (Cr), NAA/Cr, NAA/Cho and Cho/Cr ratios at 1.5 T scanner. The voxels were located over the right and left thalamus.ResultsThe IGE patients showed worse cognitive performance in IQ, attention, executive function, and verbal and visuospatial memory domains compared to the controls. The IGE patients exhibited a significantly decrease NAA in the right thalamus (p = 0.004) and a lower NAA/Cr ratio in the left thalamus (p = 0.01). the mean thalamus NAA level exhibited a positive correlation with CDT (r = 0.45,p = P = 0.01), and WMS-R (r = 0.39,p = 0.03) and a negative correlation with trail-making A test (r = 0.42,P = 0.01).Conclusionsit was concluded that IGE patients exhibited poor cognition which could be attributed to thalamic neurometabolic changes due to impaired thalamic cortical circuits.
Deep venous stenting in females
Authors: O’Sullivan Gerry , Smith Steven 
Published: March 2023

AbstractDeep venous stenting has gained increasing prominence in recent years. This issue focuses on special considerations in female patients. The specific challenge relates to the fact that these patients are often much younger than those in whom arterial stents are placed. The stents have to perform adequately over potentially 60 years- and there is no data of that length available.
Construction and characterization of the infectious cDNA clone of the prevalent Chinese strain SC3 of soybean mosaic virus
Authors: Liu Hui , Zheng Huanfang , Xiang Wenyang , Song Yingpei , Li Bowen , Yin Jinlong , Liu Mengzhuo , Liu Xiaoxiang , Wang Liqun , Yang Shouping , Xu Kai , Zhi Haijian 
Published: March 2023

AbstractThe resistance of different soybean varieties to the Chinese isolate SC3 of soybean mosaic virus (SMV) was systematically studied. However, the resistance of different germplasm sources is still poorly understood. We constructed an infectious DNA clone of SMV-SC3 (pSC3) and modified it to allow the expression of yellow fluorescence protein (YFP)/ red fluorescence protein (RFP) during viral infection. By using the infection of pSC3-RFP, we can classify the resistance of different soybean cultivars to SMV-SC3 to the extreme resistance that restricts initial viral replication and the resistance that allows viral replication in the initially inoculated cells but restricts further movement. Also, we tracked the SMV-SC3 infection in susceptible cultivar Nannong 1138-2 (NN1138-2) and found that the seed transmission of SMV to the offspring plants can be tracked and recorded by imaging the virus-driven expression of YFP. Overall, we reveal new aspects of soybean resistance to SMV-SC3 and provide an essential tool to study the infection and transmission of SMV-SC3, which will help decipher the genes involved in SMV pathogenesis and host resistance.
The US President's Cancer Panel: A Model For Gathering Country-Level Input to Inform Cancer Control Policy and Program Initiatives
Authors: Paradis Lisa J. , Chao Ann , Rimer Barbara K. , Sandler Abby B. , Duncan Kalina , Cira Mishka Kohli , Hanisch Rachel 
Published: March 2023

PURPOSE The President's Cancer Panel (Panel) is a federal advisory committee charged with monitoring the US National Cancer Program and reporting directly to the US President. Since its creation a half century ago, the Panel has gathered input from individuals and organizations across the US cancer community and beyond and recommended actions to accelerate progress against cancer. The Panel is unique in its structure and function, and merits examination for its potential applicability in other settings worldwide. METHODS We present an overview of the general President's Cancer Panel model and describe the noteworthy and unique characteristics of the Panel that help achieve its charge. We also detail the specific processes, outputs, and achievements of the Panel appointed by President Barack Obama, which served between 2012 and 2018. RESULTS From 2012 to 2018, the Panel focused on three topics that addressed timely issues in cancer prevention and control: (1) HPV vaccination for cancer prevention, (2) connected health and cancer, and (3) value and affordability of cancer drug treatment. The Panel held 11 meetings with 165 participants who provided diverse perspectives on these issues. Four reports were delivered to the president, which were cited about 270 times in the literature. Over 20 collaborator activities, including commitments of funding, can be linked to the recommendations published in these reports. CONCLUSION The US President's Cancer Panel highlights the importance of independent advisory bodies within a national cancer control program and of national leadership support for the cancer community. The structure and function of the Panel could be applicable in other settings worldwide.
The prognostic value of ECOG performance status on overall survival among patients with metastatic prostate cancer: A systematic review of the literature and meta-analysis.
Authors: Assayag Jonathan , Kim Chai , Webster Jennifer , Chu Haitao 
Published: March 2023

124 Background: Eastern Cooperative Oncology Group Performance Status (ECOG PS) has been shown to be a strong predictor of mortality among patients with advanced cancer. However, in metastatic prostate cancer, there has been heterogeneity in the literature regarding the strength of association between different ECOG categories and overall survival (OS). Therefore, we conducted a systematic search and meta-analysis of studies reporting on the prognostic value of ECOG PS on OS within the metastatic prostate cancer population. Methods: We performed a systematic search of the literature within the Medline (PubMed) database from inception until March 21st 2022. Both trials and real-world data (RWD) studies were included. Using a random-effects model, a meta-analysis pooling ECOG categories on OS was performed separately for metastatic castrate resistant prostate cancer (mCRPC) and metastatic castrate sensitive prostate cancer (mCSPC) studies. We also stratified the analyses by prior use of chemotherapy and study type (RWD vs. Trial). Between-study heterogeneity was analyzed using the I2 statistic. Results: A total of 75 studies met the eligibility criteria, comprising of 32,298 patients. Nearly all studies (72 out of 75) were among patients with mCRPC, while the remaining three studies were among mCSPC patients. Overall, all ECOG PS categories were associated with OS, with the highest estimate observed among mCRPC patients with ECOG PS of ≥2 vs. <2 ([HR] = 2.10; 95% confidence interval [CI]: 1.87 to 2.37). In secondary analyses, among mCRPC patients with ECOG PS of ≥1 vs. <1, there was a significant difference according to study type (RWD: HR=1.98, 95% CI: 1.73 to 2.26 vs. trials HR=1.32, 95% CI: 1.13 to 1.54). There were no significant differences in the pooled HR of OS stratified by previous chemotherapy across all three ECOG PS categories. Conclusions: Overall, ECOG PS was a significant predictor of OS regardless of category, previous chemotherapy, and type of metastatic population, although differences were observed in RWD vs. trial populations. Additional studies are needed to quantify the association between ECOG PS and OS in the mCSPC population, as well as to better understand the role of ECOG PS on outcomes in RWD vs. trials of cancer treatments.
P-MCP treatment in non-metastatic biochemically relapsed prostate cancer (BRPC-M0): Final long-term results of a prospective phase II study.
Authors: Keizman Daniel , Frenkel Moshe A. , Peer Avivit , Kushnir Igal , Rosenbaum Eli , Sarid David Leonid , Leibovitch Ilan , Mano Roy , Yossepowitch Ofer , Margel David , Wolf Ido , Geva Ravit , Rouvinov Keren , Dresler Hadas , Eliaz Isaac 
Published: March 2023

162 Background: 30% of patients with localized PC will have a biochemical relapse post local therapy. Their optimal treatment remains elusive. While androgen deprivation therapy is effective in reducing PSA level, its long-term benefit remains undefined, and it is toxic. Thus, evaluation of new nontoxic compounds in these patients is warranted. PectaSol-C modified citrus pectin (P-MCP) is an inhibitor of galectin-3 protein, which is involved in prostate cancer pathogenesis. We herein report the final long-term results of a multi-center phase 2 study of P-MCP treatment in BRPC-M0. Methods: Patients with BRPC-M0 were enrolled and treated with P-MCP, 4.8 grams X 3/day, for 6 months (first phase of trial). Patients without PSA progression and/or with improvement of PSA doubling time (PSADT), and with negative scans, were treated for an additional 12 months (second phase of trial). Results: 59 patients were initially enrolled. After initial 6 months of therapy, 46 patients (78%) without disease progression entered the second phase of additional 12 months therapy. Among them, 7 patients withdrew consent and chose to continue therapy out of pocket. Of the remaining 39 patients, after another year of therapy (total of 18 months), 85% (n=33) had an overall long-term response, with a decreased/stable PSA (62 %, n=24), and improvement of PSADT (90 %, n=35), and with negative scans. No patient had grade 3/4 toxicity. Conclusions: P-MCP may have a durable long-term efficacy in patients with BRPC-M0. Clinical trial information: NCT01681823 .