bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurophysiological Evidence for Semantic Processing of Irrelevant Speech and Own-Name Detection in a Virtual Café
Authors: Brown Adi , Pinto Danna , Burgart Ksenia , Zvilichovsky Yair , Zion-Golumbic Elana 
Published: June 2023

The well-known “cocktail party effect” refers to incidental detection of salient words, such as one's own-name, in supposedly unattended speech. However, empirical investigation of the prevalence of this phenomenon and the underlying mechanisms has been limited to extremely artificial contexts and has yielded conflicting results. We introduce a novel empirical approach for revisiting this effect under highly ecological conditions, by immersing participants in a multisensory Virtual Café and using realistic stimuli and tasks. Participants (32 female, 18 male) listened to conversational speech from a character at their table, while a barista in the back of the café called out food orders. Unbeknownst to them, the barista sometimes called orders containing either their own-name or words that created semantic violations. We assessed the neurophysiological response-profile to these two probes in the task-irrelevant barista stream by measuring participants' brain activity (EEG), galvanic skin response and overt gaze-shifts.SIGNIFICANCE STATEMENTWe found distinct neural and physiological responses to participants' own-name and semantic violations, indicating their incidental semantic processing despite being task-irrelevant. Interestingly, these responses were covert in nature and gaze-patterns were not associated with word-detection responses. This study emphasizes the nonexclusive nature of attention in multimodal ecological environments and demonstrates the brain's capacity to extract linguistic information from additional sources outside the primary focus of attention.
PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
Authors: Kraus Felix , Goodall Ellen A , Smith Ian R , Jiang Yizhi , Paoli Julia C , Adolf Frank , Zhang Jiuchun , Paulo Joao A , Schulman Brenda A , Harper J Wade 
Published: June 2023

AbstractThe protein kinase PINK1 and ubiquitin ligase Parkin promote removal of damaged mitochondria via a feed‐forward mechanism involving ubiquitin (Ub) phosphorylation (pUb), Parkin activation, and ubiquitylation of mitochondrial outer membrane proteins to support the recruitment of mitophagy receptors. The ubiquitin ligase substrate receptor FBXO7/PARK15 is mutated in an early‐onset parkinsonian–pyramidal syndrome. Previous studies have proposed a role for FBXO7 in promoting Parkin‐dependent mitophagy. Here, we systematically examine the involvement of FBXO7 in depolarization and mtUPR‐dependent mitophagy in the well‐established HeLa and induced‐neurons cell systems. We find that FBXO7−/− cells have no demonstrable defect in: (i) kinetics of pUb accumulation, (ii) pUb puncta on mitochondria by super‐resolution imaging, (iii) recruitment of Parkin and autophagy machinery to damaged mitochondria, (iv) mitophagic flux, and (v) mitochondrial clearance as quantified by global proteomics. Moreover, global proteomics of neurogenesis in the absence of FBXO7 reveals no obvious alterations in mitochondria or other organelles. These results argue against a general role for FBXO7 in Parkin‐dependent mitophagy and point to the need for additional studies to define how FBXO7 mutations promote parkinsonian–pyramidal syndrome.
Speaker stance and engagement across disciplines in Lithuanian university lectures: the case of mes ‘we’ in medicine and business administration
Authors: Maslauskienė Greta 
Published: June 2023

To gain a greater understanding of how speakers construct their disciplinary-situated identities and interact with their addressee(s) in Lithuanian spoken academic discourse, this corpus-based exploratory analysis focuses on the use of mes ‘we’ as a marker of stance and engagement in lecturers’ speech in Lithuanian university lectures on business administration and medicine. The data reveals that the lecturers in business administration used only the inclusive mes ‘we’, which is known to promote student involvement and strengthen lecturer-student rapport. The instructors in medicine frequently employed the exclusive reference to indicate their belonging to professional communities and highlight their level of expertise in the discipline, creating a sense of distance between the lecturer and the student audience.
ABERRANT EXPRESSION OF COL14A1, CELRS3, and CTHRC1 IN BREAST CANCER СELLS
Authors: Malvia Shreshtha , Chintamani Chintamani , Sarin Ramesh , Dubey Uma S , Saxena Sunita , Bagadi Sarangadhara Appala Raju 
Published: June 2023

Background: Collagens, which are the major components of the extracellular matrix involved in the regulation of tumor microenvironment, could be differentially expressed in breast cancer (BC) with different transcriptome profiling. Aim: To analyze the transcript level expression of COL1A1, COL5A1, COL10A1, COL11A1, COL12A1, COL14A1, CTHRC1, and CELRS3 genes and the clinical relevance of their differential expression in BC. Materials and Methods: The transcript level expression of the genes was analyzed using the quantitative real-time PCR (qPCR) in tumor tissue of 60 BC patients. Results: Overexpression of COL1A1, COL5A1, COL10A1, COL11A1, COL12A1, CTHRC, and CELRS3 anddown-regulated expression of COL14A1 were observed. COL14A1 down-regulation was associated with aggressive, basal, and Her-2/neu BC subtypes (p = 0.031). Overexpression of CELSR3 was found to be associated with the older age of the patients (> 55 years, p = 0.049). Further analysis with the TCGA BC data set has shown a concordance in the differential expression of the above genes. Furthermore, overexpression of CTHRC1 was associated with poor overall survival (OS), particularly with poor prognosis (p = 0.00042) for the luminal BC subtype. On the other hand, CELSR3 overexpression was associated with mucinous tumors and poor prognosis in post-menopausal women. In silicotarget prediction identified several BC-associated miRNAs and members of miR-154, -515, and -10 families to perform a likely regulatory role in the above ECM genes. Conclusion: The present study shows that the expression of COL14A1 and CTHRC1 may serve as potential biological markers for the detection of basal BC and the prognosis of survival for patients with the luminal subtype of BC.
Late antique Mediterranean rotary keys from Avaria
Authors: Bollók Ádám 
Published: June 2023

AbstractThe present paper describes and discusses a group of iron and copper-alloy rotary keys characterised by a moveable joint connecting the shaft and the key-ring, appearing in the seventh-century material record of the Carpathian Basin whose origins can be sought in the Mediterranean. While the few published examples of the class were in previous studies mainly regarded as Roman-period artefacts secondarily re-used as amulets by the Avar-period population of the Carpathian Basin, the present study argues that these pieces in fact have a sixth-to seventh-century production date, being thereby contemporaneous with their deposition in seventh-century mortuary assemblages. Taking this observation as a springboard for further interpretation, an overview of the possible meanings and symbolic associations attached to keys in Roman, late antique, and early medieval times is offered. The main argument presented here is that besides serving amuletic purposes, some of the Avar-period keys could in all probability have conveyed more explicit messages about their owners, such as that of their feminity and of their economic role and authority in their respective households. The Appendix supplementing the present paper seeks to provide a theoretical reconstruction of a wooden casket buried with the woman interred in Grave 119 of the Kölked-Feketekapu B cemetery, one of the burials yielding a Mediterranean hinged rotary key.
Gambling participation among Connecticut adolescents from 2007 to 2019: Potential risk and protective factors
Authors: Stefanovics Elina A. , Gueorguieva Ralitza , Zhai Zu Wei , Potenza Marc N. 
Published: June 2023

AbstractBackground and aimsGambling in adolescents is a public health concern. This study sought to examine patterns of gambling among Connecticut high-school students using seven representative samples covering a 12-year period.MethodsData were analyzed from N = 14,401 participants in cross-sectional surveys conducted every two years based on random sampling from schools in the state of Connecticut. Anonymous self-completed questionnaires included socio-demographic data, current substance use, social support, and traumatic experiences at school. Chi-square tests were used to compare socio-demographic characteristics between gambling and non-gambling groups. Logistic regressions were used to assess changes in the prevalence of gambling over time and effects of potential risk factors on the prevalence, adjusted for age, sex, and race.ResultsOverall, the prevalence of gambling largely decreased from 2007 to 2019, although the pattern was not linear. After steadily declining from 2007 to 2017, 2019 was associated with increased rates of gambling participation. Consistent statistical predictors of gambling were male gender, older age, alcohol and marijuana use, higher levels of traumatic experiences at school, depression, and low levels of social support.Discussion and conclusionAmong adolescents, older males may be particularly vulnerable to gambling that relates importantly to substance use, trauma, affective concerns, and poor support. Although gambling participation appears to have declined, the recent increase in 2019 that coincides with increased sports gambling advertisements, media coverage and availability warrants further study. Our findings suggest the importance of developing school-based social support programs that may help reduce adolescent gambling.
Who makes in-play bets? Investigating the demographics, psychological characteristics, and gambling-related harms of in-play sports bettors
Authors: Vieira Jenna L. , Coelho Sophie G. , Snaychuk Lindsey A. , Parmar Puneet K. , Keough Matthew T. , Kim Hyoun S. 
Published: June 2023

AbstractBackground and aimsSports betting has increased markedly in recent years, in part due to legislative changes and the introduction of novel forms of sports betting (e.g., in-play betting). Some evidence suggests that in-play betting is more harmful than other types of sports betting (i.e., traditional and single-event). However, existing research on in-play sports betting has been limited in scope. To address this gap, the present study examined the extent to which demographic, psychological, and gambling-related constructs (e.g., harms) are endorsed by in-play sports bettors relative to single-event and traditional sports bettors.MethodsSports bettors (N = 920) aged 18+ from Ontario, Canada completed an online survey containing self-report measures of demographic, psychological, and gambling-related variables. Participants were classified as either in-play (n = 223), single-event (n = 533), or traditional bettors (n = 164) based on their sports betting engagement.ResultsIn-play sports bettors reported higher problem gambling severity, endorsed greater gambling-related harms across several domains, and reported greater mental health and substance use difficulties compared to single-event and traditional sports bettors. There were generally no differences between single-event and traditional sports bettors.DiscussionResults provide empirical support for the potential harms associated with in-play sports betting and inform our understanding of who may be at risk for increased harms associated with in-play betting.ConclusionsFindings may be important for the development of public health and responsible gambling initiatives to reduce the potential harms of in-play betting, particularly as many jurisdictions globally move towards legalization of sports betting.
Dnajb11-Kidney Disease Develops from Reduced Polycystin-1 Dosage but not Unfolded Protein Response in Mice
Authors: Ghosh Roy Sounak , Li Zhigui , Guo Zi , Tran Long Kelly , Rehrl Sonja , Tian Xin , Dong Ke , Besse Whitney 
Published: June 2023

Significance Statement
Heterozygous DNAJB11 mutation carriers manifest with small cystic kidneys and renal failure in adulthood. Recessive cases with prenatal cystic kidney dysplasia were recently described. Our in vitro and mouse model studies investigate the proposed disease mechanism as an overlap of autosomal-dominant polycystic kidney disease and autosomal-dominant tubulointerstitial kidney disease pathogenesis. We find that DNAJB11 loss impairs cleavage and maturation of the autosomal-dominant polycystic kidney disease protein polycystin-1 (PC1) and results in dosage-dependent cyst formation in mice. We find that Dnajb11 loss does not activate the unfolded protein response, drawing a fundamental contrast with the pathogenesis of autosomal-dominant tubulointerstitial kidney disease. We instead propose that fibrosis in DNAJB11-kidney disease may represent an exaggerated response to polycystin-dependent cysts.

Background
Patients with heterozygous inactivating mutations in DNAJB11 manifest with cystic but not enlarged kidneys and renal failure in adulthood. Pathogenesis is proposed to resemble an overlap of autosomal-dominant polycystic kidney disease (ADPKD) and autosomal-dominant tubulointerstitial kidney disease (ADTKD), but this phenotype has never been modeled in vivo. DNAJB11 encodes an Hsp40 cochaperone in the endoplasmic reticulum: the site of maturation of the ADPKD polycystin-1 (PC1) protein and of unfolded protein response (UPR) activation in ADTKD. We hypothesized that investigation of DNAJB11 would shed light on mechanisms for both diseases.

Methods
We used germline and conditional alleles to model Dnajb11-kidney disease in mice. In complementary experiments, we generated two novel Dnajb11

−/−
cell lines that allow assessment of PC1 C-terminal fragment and its ratio to the immature full-length protein.

Results

Dnajb11 loss results in a profound defect in PC1 cleavage but with no effect on other cystoproteins assayed. Dnajb11

−/−
mice are live-born at below the expected Mendelian ratio and die at a weaning age with cystic kidneys. Conditional loss of Dnajb11 in renal tubular epithelium results in PC1 dosage-dependent kidney cysts, thus defining a shared mechanism with ADPKD. Dnajb11 mouse models show no evidence of UPR activation or cyst-independent fibrosis, which is a fundamental distinction from typical ADTKD pathogenesis.

Conclusions

DNAJB11-kidney disease is on the spectrum of ADPKD phenotypes with a PC1-dependent pathomechanism. The absence of UPR across multiple models suggests that alternative mechanisms, which may be cyst-dependent, explain the renal failure in the absence of kidney enlargement.
PROGNOSTIC SIGNIFICANCE OF LOW QRS VOLTAGE ON THE ADMISSION ELECTROCARDIOGRAM IN ACUTE CORONARY SYNDROMES
Authors: Mawlood Swara , Ahmed Farman , Al-Hamdi Amar , Arif Mohammad 
Published: June 2023

Background
Myocardial infarction is one of the most common causes of mortality in middle and older age groups, especially in ventricular arrhythmia. Patients will be identified as having low QRS Voltage when peak-to-peak QRS complex voltage is less than 0.5 mV in all limb leads and less than 1.0 mV in all precordial leads.
Objectives
To find the correlation between low QRS voltage in the hospital and one-month outcome of patients presenting with the acute coronary syndrome.
Patients and Methods
A prospective longitudinal study was performed on 400 patients admitted with the confirmed acute coronary syndrome and underwent percutaneous coronary intervention.
Results
The mean age was 61. ± 11.8years ranged from 22 to 90 years. Male was 67.8%, and 32.3% were female. The percentage of hypertension, diabetes mellitus, and previous myocardial infarction were 66.3%, 32.8% and 12.3%, respectively. Low QRS voltage was found in 17 patients (4.3%). Most of our patients (43.5%) had an anterior myocardial infarction, of which the culprit lesion was the Left Anterior Descending artery. An ejection fraction of more than 50% on echocardiography was found in 68.3% of them; additionally, 84.7% had a Killip Class of one. Therefore, in-hospital death was 4.8%. Furthermore, the total death from admission to a month post-myocardial infarction was 9%. Fourteen patients had re-admission within that period for cardiac events.
Conclusion
Low QRS in presenting electrocardiogram patients with the acute coronary syndrome will be significantly associated with hospital and one-month morbidity and mortality.
Anti-proliferative potentials of Aconitum heterophyllum Root Extract in Human Breast cancer (MDA-MB-231) cell lines-Genetic and Antioxidant enzyme approach
Authors: Saravanan Sujatha , Hari Rajeswari , Sekar Karthikeyan 
Published: June 2023

Background: One of the most important research activities around the world is the screening of various plant components for novel anticancer medicines. The anticancer activities of Aconitum heterophyllum were studied in human breast cancer MDA-MB- 231 cells in this study. Since tumorigenesis is thought to be the result of a series of pro- gressive gene alterations, including oncogene activation and tumour suppressor gene in- activation, the expression of genes like p53, p21, STAT, and Bcl-2, which are thought to be important in tumorigenesis and cell death, was determined. In the present study there was an upregulation in the level expression of p53and p21 and down regulation in the expression of BCL2 and STAT. However, there is increase and decrease level of gene expression in Aconitum heterophyllum roots loaded Phyto-Niosomes (nEEAH), when compared to ethanolic root extract of Aconitum heterophyllum EEAH extract treated MDA-MB-231 cell lines.
Methods: The enzymatic antioxidants such as CAT, SOD, GR, GST, and GPX as well as non-enzymatic antioxidants such as glutathione, Vitamin E and Vitamin C were esti- mated in the treated MDA-MB-231 cells at the end of incubation. The RT-PCR tech- nique was performed to study the expression patterns of apoptotic genes such as p53 and p21 and anti-apoptotic genes BCL2 and STAT in the drug treated MDA-MB-231 cells
Results: In the present study there was a significant (p<0.05) increase in CAT and glutathione levels and a decrease in Vit C, Vit E and SOD, GR, GST, GPX levels in the untreated MDA-MB-231 cells. Increased apoptotic gene expression and decreased anti-apoptotic gene expression suggest the anti-proliferative nature of the drug extract was comparable to the doxorubicin the positive drug used in the present study.
Conclusion: It can be concluded that the ethanolic extract of Aconitum heterophyllum roots loaded Phyto-Niosomes (nEEAH), when compared to ethanolic root extract of Aconitum heterophyllum EEAH extract treated MDA-MB-231 cell lines exert its anticancer activity by activating the apoptotic genes, suppressing anti-apoptotic genes as well as modulating the antioxidant enzymes.
Pseudo-judicial Review for the Dispute over the Result of the Regional Head Election in Indonesia
Authors: Indra Mexsasai , Saragih Geofani Milthree , Handoko Tito 
Published: June 2023

In Indonesia, the Constitutional Court has the power to decide the dispute over the result of the national election, including that of the regional head election. In practice, the Constitutional Court exercises power with the so-called pseudo-judicial review for the result of the regional election dispute. This study aims to analyse the rationale of the Constitutional Court to implement a pseudo-judicial review over the regional head election result, given the judicial activism that also is limited to checks and balances. It also links the theoretical basis for rule-breaking and judicial activism by the Constitutional Court, the transition of the Constitutional Court's power in deciding regional election disputes from temporary to permanent, as well as further analysis of why the Constitutional Court needs to file a lawsuit for review. This study used legal research that examined legal principles and regulations with a theoretical approach analysed qualitatively. The results of this study indicate that pseudo-judicial review affirms the legal breakthrough beyond ordinary decisions as this was made on the ground of the public interest. While the Constitutional Court is essential in maintaining and overseeing democracy in Indonesia, the rationale of the Constitutional Court under the public interest is justified as it is constitutionally correct that has led to judicial activism. A pseudo-judicial review is for substantial justice and can influence time efficiency.
Navigating Human Rights in Indonesia and Beyond
Authors: Ulum Muhammad Bahrul , Dinata Ari Wirya 
Published: June 2023

In Indonesia, promoting human rights is a long battle run. Human rights were just formally recognised when Suharto's authoritarian regime ended in 1998, but these rights have experienced a rise and fall throughout the Reformasi. Indonesia successfully amended the 1945 Constitution with more human rights provisions and enacted Human Rights Law 39/1999. However, this country still faces the challenges of ensuring that human rights are promoted with the state’s obligation to respect, protect and fulfil amidst the debates on institutional reforms, universalism and relativism, as well as the limited powers of the national human rights institutions. Along with efforts to ensure that democracy and human rights can coexist, democratisation in Indonesia is also inextricably linked to advancing human rights. After two decades of Indonesia's reform, human rights and democracy have become vital cornerstones, but they have experienced serious challenges in their promotion. From the Indonesian context, these discourses can relate to those discourses in other Global South countries, like India, that this edition will elaborate on due to their relatively similar and unique pathways with arduous tasks in managing domestic affairs. Indonesia can represent critical, which is more likely underrepresented discourses with robust arguments on various social, economic, political and cultural situations in the Southern Hemisphere, from which these debates endure and are usually more centred on the West and, to some extent, the Global North. These discourses from the Global South countries can provide a frequently unheard perspective to current discussions on human rights. By navigating human rights in Indonesia and beyond, these discourses highlight how the new justification of human rights can contribute to emancipatory initiatives.
KESESUAIAN PRINSIP RETALIASI DALAM KASUS PERANG PERDAGANGAN ANTARA AMERIKA SERIKAT DAN TIONGKOK
Authors: Savira Gina Nafsah 
Published: June 2023

<div>Penelitian ini menggambarkan dan meneliti masalah tentang apakah tindakan yang dilakukan oleh Amerika Serikat terhadap China atau sebaliknya sesuai dengan aturan pembalasan dalam perdagangan internasional. Penelitian ini adalah penelitian hukum normatif preskriptif. Data sekunder yang digunakan adalah bahan hukum primer, sekunder, dan tersier. Teknik pengumpulan data yang digunakan adalah penelitian kepustakaan, instrumen penelitian dalam bentuk Pemahaman Penyelesaian Sengketa,</div><div>Perjanjian Umum tentang Tarif dan Perdagangan, Perjanjian tentang Safeguards, AS-China Relation Act, kemudian analisis teknis yang digunakan adalah metode deduktif. Hasil penelitian menunjukkan bahwa kebijakan ekonomi yang dilakukan oleh AS disebut solusi perdagangan dalam bentuk proteksionisme yang mengacu pada tindakan pengamanan dalam kerangka hukum WTO. Solusi perdagangan bertujuan untuk meminimalkan dampak negatif impor pada produk dalam negeri. Selanjutnya, tindakan yang diambil oleh Tiongkok adalah salah satu contoh tindakan perbaikan dalam bentuk pembalasan.</div><div id="highlighter--hover-tools" style="display: none;"> </div>