bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of the use of mobile alerting to inform the public about emergencies and the factors that influence the public response
Authors: Mowbray Fiona , Mills Freya , Symons Charles , Amlôt Richard , James Rubin G. 
Published: September 2023

AbstractDuring an emergency, it is necessary to quickly disseminate messages to the public. These communications often provide information about the emergency as well as guidance or advice aimed at ensuring the safety of the population. Successful emergency communication depends upon how rapidly and reliably a message can be disseminated, but also on how people respond to the message that they receive. To assist emergency planners tasked with developing message sets for future incidents, in this paper we report a systematic review of all studies that assessed the impact of mobile telephone alerting systems on intended and actual behaviour, to identify factors that affect their likely impact. We searched multiple databases and conferred with topic experts, resulting in a total of 22 studies which met the inclusion criteria. Our results indicate that limited data exist on how people respond to text‐based warning messages and that much of the data is poor quality, indicating a need for more real‐world studies.
Business continuity and resilience management: A conceptual framework
Authors: Steen Riana , Haug Ole Jacob , Patriarca Riccardo 
Published: September 2023

AbstractThe overall objective of business continuity management (BCM) systems is to provide guidance and analytical subcomponents on how to assess and manage risk and sustain operations when facing a disruptive event. Current BCM practices largely follow a standard structure for formal planning processes and risk‐assessment activities. An underlying assumption in standard practices is that systems can be decomposed in subsystems in a meaningful way, as they are tractable and data are available to predict the system's future functionality. However, the reality is much more complex in our volatile world. Standard BCM approaches do not pay adequate attention to the treatment of uncertainties. Thus, they fall short of addressing the complexity of operations involved with emergencies and crisis. Lack of focus on uncertainty hampers the ability of BCM systems to provide sufficient support for decision making in highly uncertain situations. Dealing with such situations necessitates a shift from a defensive risk‐management approach, grounded on an illusion of control and accountability, to a proactive stance based on resilience thinking. Responding to this call, we use concepts from the resilience engineering (RE) field and link them to different components of a BCM system. We develop a novel BCM framework and identify a set of resilience influence factors to enhance resilience in BCM systems. We use a case‐example, hosted by a leading organization in a second‐line emergency response operation in Norway to reflect on the application of a suggested BCM framework.
Barriers to accessing pain management services among veterans with bipolar disorder
Authors: Travaglini Letitia E. , Bennett Melanie , Kacmarek Corinne N. , Kuykendall Lorrianne , Coakley Gabriella , Lucksted Alicia 
Published: September 2023

AbstractObjectiveTo identify barriers veterans with bipolar disorder face to accessing chronic pain management services within a Veterans Affairs (VA) health care system.Data Sources and Study SettingVeterans (n = 15) with chronic pain and bipolar disorder and providers (n = 15) working within a mid‐Atlantic VA health care system. Data were collected from August 2017–June 2018.Study DesignVeteran interviews focused on their chronic pain experiences and treatment, including barriers that arose when trying to access pain management services. Provider interviews focused on whether they address chronic pain with veteran patients and, if so, what considerations arise when addressing pain in veterans with bipolar disorder and other serious mental illnesses.Data CollectionVeterans were at least 18 years old, had a confirmed bipolar disorder and chronic pain diagnosis, and engaged in outpatient care within the VA health care system. Clinicians provided direct care services to veterans within the same VA. Interviews lasted approximately 60 min and were transcribed and analyzed using a rapid analysis protocol.Principal FindingsFour major themes emerged from veteran and provider interviews: siloed care (unintegrated and uncoordinated mental and physical health care), mental health primacy (prioritization of mental health symptoms at expense of physical health symptoms), lagging expectations (unfamiliarity with comprehensive evidence‐based pain management options), and provider–patient communication concerns (inefficient communication about pain concerns and treatment options).ConclusionsVeterans with co‐occurring pain and bipolar disorder face unique barriers that compromise equitable access to evidence‐based pain treatment. Our findings suggest that educating providers about bipolar disorder and other serious mental illnesses and the benefit of effective non‐pharmacological pain interventions for this group may improve care coordination and care quality and reduce access disparities.
Pro‐environmental intention toward sustainable rangeland's management; application of protection motivation and cultural theories
Authors: Madadizadeh Neamat Allah , Arzani Hossein , Javadi Seyed Akbar , Mohammadi Seyed Hamid Movahed , Razzaghi Mohammad Hossein 
Published: September 2023

AbstractThis empirical study attempts to deal with an exploration gap surrounding Iranian pastoralists' pro‐environmental intention regarding sustainable rangeland management. This study tested a combination of protection motivation and cultural values theories using structural equation modeling. A sample among rangeland's users was selected and the sample size was determined using Cochrane's (1963) formula to be 289. Data for this study were collected using a researcher‐made questionnaire. Data were analyzed using SPSS (version 20) and AMOS (version 20). The results showed that the conceptual model of this study had a good fit with the data. The combination of the two theories showed good potential in predicting the pro‐environmental intention of rangeland users (51%) compared with previous researches. The results revealed that risk perception, maladaptation, and belief in land degradation directly influence rangeland's pro‐environmental intention.
Assessing the impact of obturation techniques, kinematics and irrigation protocols on apical debris extrusion and time required in endodontic retreatment
Authors: Pedullà Eugenio , Iacono Francesco , Pitrolo Martina , Barbagallo Giovanni , La Rosa Giusy Rita Maria , Pirani Chiara 
Published: September 2023

AbstractThe aim of the study was to evaluate the impact of kinematics and irrigation protocols on the extrusion of apical debris during removal of different obturation techniques. A total of 144 single‐rooted teeth were instrumented and obturated with Thermafil+AH Plus, Thermafil+AH Plus Bioceramic and single gutta‐percha cone+AH Plus Bioceramic. Samples were divided according to the retreatment kinematics: continuous rotation or Jeni motion. Each sub‐group was subjected to conventional irrigation or irrigation activated by EDDY. Extruded debris was collected in Eppendorf tubes, weighted and retreatment time was digitally recorded. Data were analysed with two‐way ANOVA (p < 0.05). Debris extrusion was not significantly different between all groups. EDDY activation system and CanalPro Jeni required significantly longer time compared with other groups to remove Thermafil+AH Plus and single cone+AH Plus Bioceramic. Within current limitations, obturation technique, irrigation protocol and kinematics tested had no influence on apical extrusion debris, while they significantly impacted the retreatment time.
“What's Wrong with the Elevators”: From Breakdown to Policing in Chicago Public Housing
Authors: Hamlin Madeleine 
Published: September 2023

AbstractIn this paper, I argue that the high‐rise elevator comprises a particularly important and yet heretofore undertheorised space for understanding narratives about failure and breakdown in public housing in the US and beyond. Using Chicago as a case study, I draw upon historical newspaper articles and interviews with former public housing tenants, as well as interviews with former police officers who worked in public housing developments, to show how broken and vandalised elevators became a metonym in public discourse for the widely perceived “brokenness” of high‐rise public housing writ large. Insofar as malfunctioning elevators symbolised social immobility, were seen as a locus of crime, and drained the housing authority's finances, they also became a site of intensive policing. When that intensive policing failed to solve structural problems in Chicago's public housing high rises, policymakers demolished them.
Why and when do emotionally intelligent employees perform safely? The roles of thriving at work and career adaptability
Authors: Wang Zhongmin , Jiang Zhou , Blackman Anna 
Published: September 2023

AbstractBased on the socially embedded model of thriving, the present study examined a moderated mediation framework, which involves the mediating role of employee thriving and the moderating role of career adaptability in the relationship between emotional intelligence (EI) and safety performance. A two‐wave survey was administered among full‐time commercial pilots working for airlines (N = 131). Our results showed that EI had a positive influence on employee thriving, which in turn positively affected safety performance. In addition, the results further revealed that the positive effect of EI on safety performance was stronger among pilots with a higher level of career adaptability. These findings have important implications for theoretical developments on EI, thriving, and performance in a safety context, and they also provide practical insights on how to enhance workplace safety.
Letter: HRS‐AKI – a frequent misdiagnosis in the real‐world setting?
Authors: Mehtani Rohit , De Arka , Singh Virendra 
Published: September 2023

LINKED CONTENTThis article is linked to Moore et al papers. To view these articles, visit https://doi.org/10.1111/apt.15836 and https://doi.org/10.1111/apt.16001
Letter: now is the time to remove complexity from HCV guidelines to ensure that elimination remains a priority
Authors: Turnes Juan , Hezode Christophe , Hernandez Candido , Mangia Alessandra 
Published: September 2023

LINKED CONTENTThis article is linked to Singh et al and Singh and Shalimar papers. To view these articles, visit https://doi.org/10.1111/apt.15633 and https://doi.org/10.1111/apt.16011
Letter: does tranexamic acid reduce the need for surgery in patients with upper gastrointestinal bleeding?
Authors: Lee Po‐Lin , Suk Fat‐Moon , Kang Yi‐No 
Published: September 2023

LINKED CONTENTThis article is linked to Twum‐Barimah et al paper. To view this article, visit https://doi.org/10.1111/apt.15761
Editorial: genome‐wide association for developing chronic hepatitis B—authors’ reply
Authors: Lee Mei‐Hsuan , Huang Yu‐Han 
Published: September 2023

LINKED CONTENTThis article is linked to Huang et al and Hoek papers. To view these articles, visit https://doi.org/10.1111/apt.15887 and https://doi.org/10.1111/apt.15960
Letter: now is the time to remove complexity from HCV guidelines to ensure that elimination remains a priority—authors' reply
Authors: Singh Achintya Dinesh , Shalimar  
Published: September 2023

LINKED CONTENTThis article is linked to Singh et al and Turnes et al papers. To view these articles, visithttps://doi.org/10.1111/apt.15633andhttps://doi.org/10.1111/apt.15978
Editorial: thiopurine/anti‐TNF use during pregnancy—more encouraging safety data. Authors' reply
Authors: Mertz Nørgård Bente , Friedman Sonia 
Published: September 2023

LINKED CONTENTThis article is linked to Nørgård et al and Chowdhury & Kane papers. To view these articles, visit https://doi.org/10.1111/apt.15956 and https://doi.org/10.1111/apt.16017
Editorial: serum oncostatin M at baseline predicts mucosal healing in Crohn's disease patients treated with infliximab—authors' reply
Authors: Bertani Lorenzo , Fornai Matteo , Antonioli Luca , Blandizzi Corrado 
Published: September 2023

LINKED CONTENTThis article is linked to Bertani et al and Appleton and Day papers. To view these articles, visithttps://doi.org/10.1111/apt.15870andhttps://doi.org/10.1111/apt.15987
Letter: Covid‐19—re‐initiating clinical services for chronic gastrointestinal diseases. How and when?
Authors: Britton Edward , Richardson Paul , Mian Ibrahim , Conley Thomas , Byrne David , Boyd Holly , Doherty Connor , Gupta Sandipika , Butt Sundas , Subramanian Sreedhar 
Published: September 2023

LINKED CONTENTThis article is linked to Al‐Ani et al and Prentice et al papers. To view these articles, visit https://doi.org/10.1111/apt.15779 and https://doi.org/10.1111/apt.16065
Pregnancy in women with inflammatory bowel disease: a French nationwide study 2010‐2018
Authors: Meyer Antoine , Drouin Jérôme , Weill Alain , Carbonnel Franck , Dray‐Spira Rosemary 
Published: September 2023

SummaryBackgroundInflammatory bowel disease (IBD) most commonly occurs in young adults, including women of child‐bearing age.AimTo describe pregnancy in women with IBD in the age of widespread use of biologicsMethodsUsing French national health data system (SNDS) data, we identified all pregnancies ending between 1 April 2010 and 31 December 2018 in patients with and without IBD in France. Pregnancy and IBD characteristics were described. Pregnancy outcomes were compared between IBD and non‐IBD pregnancies using multivariable logistic regression models.ResultsWe included 36 654 IBD and 8 595 562 non‐IBD pregnancies. Among IBD pregnancies, 75.6% ended in live births and 0.4% in stillbirths. Pregnancies in women with IBD vs those without IBD more frequently resulted in preterm birth (8.0% vs 5.5%, aOR 1.51; 95% CI: 1.45‐1.58), small for gestational age birth (11.1% vs 9.8%, aOR 1.15; 95% CI: 1.10‐1.20) and caesarean section (26.1% vs 20.0%, aOR 1.39; 95% CI: 1.35‐1.42). Active IBD before and during pregnancy was associated with particularly marked increases in the rates of prematurity and small for gestational age as compared to non‐IBD pregnancies. Active IBD during pregnancy was associated with more stillbirths than non‐IBD pregnancies (aOR 1.43 95% CI: 1.09‐1.86). Crohn's disease activity decreased during pregnancy, while ulcerative colitis activity did not change.ConclusionsPregnancies in women with IBD are associated with increased risks of prematurity, small for gestational age and caesarean section, especially among women with active IBD. Disease activity decreased during pregnancy in women with Crohn's disease, but was unchanged in women with ulcerative colitis.
Paroxysmal nocturnal haemoglobinuria (PNH): novel therapies for an ancient disease
Authors: Luzzatto Lucio , Karadimitris Anastasios 
Published: September 2023

SummaryIn the UK, early work on paroxysmal nocturnal haemoglobinuria (PNH) was conducted by John Dacie who, at the Hammersmith Hospital, first hypothesised that the PNH abnormality might arise through a somatic mutation; and who outlined with S.M. Lewis the relationship between PNH and aplastic anaemia. When the phosphatidylinositol glycan anchor biosynthesis Class A (PIGA) gene was identified by Taroh Kinoshita’s group, jointly with him the Hammersmith group proved that PNH is caused in most patients by a single somatic mutation in the PIGA gene. At the same time, after Bruno Rotoli had spent a sabbatical at the Hammersmith, the ‘immune escape model’ for the pathogenesis of PNH was developed. Early this century, Peter Hillmen, formerly at the Hammersmith and now in Leeds, spearheaded the use of the complement‐blocking (anti‐C5) antibody eculizumab. This new medicine radically changed the management and the clinical course of patients with PNH. Recently a derivative of eculizumab with more favourable pharmacokinetics has been introduced. In view of the fact that these agents are associated with C3‐dependent extravascular haemolysis, it is important that a number of inhibitors of the proximal complement pathway are now in the offing and may further improve the life of patients with PNH.
Developments over the last 60 years in diffuse large B‐cell lymphomas
Authors: Linch David 
Published: September 2023

SummaryAt the time of the formation of the British Society of Haematology diffuse large B‐cell lymphoma was not recognised as a specific entity and was included in the category of ‘large cell’ or ‘aggressive’ lymphomas. These were fatal in 95% of cases. Today the cure rate in adults entered into clinical trials is ~70% and a large number of British physicians have contributed to this progress.
Haemophilia, the journey in search of a cure. 1960–2020
Authors: Nathwani Amit C. , Tuddenham Edward G. D. 
Published: September 2023

SummaryThe single most important step on the path to our modern understanding of blood coagulation and haemophilia in the 20th century was taken by British pathologist Robert Gwyn Macfarlane with his 1964 publication ‘An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier’. In the same year, Ratnoff and Davie in the USA reached the same conclusion. Macfarlane and Rosemary Biggs had previously, in 1952, discovered factor IX as the factor deficient in haemophilia B. In 1973, Arthur Bloom defined the distinct role of Factor VIII and von Willebrand factor in haemophilia A and von Willebrand’s disease respectively. This inspired the efforts of Tuddenham and his group towards the purification of Factor VIII which reached homogeneity in 1982, leading to the cloning of the Factor VIII gene in 1984 in collaboration with US scientists at Genentech, which in turn enabled development of safe recombinant factor concentrates for patients with haemophilia. Brownlee cloned the factor IX gene in 1982 at the Sir William Dunn Institute of Pathology in Oxford. This led eventually to the first successful trial of gene therapy for haemophilia B in 2011 by the Nathwani group at UCL, which built on pioneering work of US groups and was partnered with St Jude in Memphis where Nathwani started the project. This trial has fuelled the current quest for a functional cure of haemophilia A and B. The UK has, therefore, made a rich contribution to advances in haemostasis over the last 60 years, often in partnership with other groups across the world.
Hairy Cell Leukaemia: From Hairy Beginnings to a BRAF New World
Authors: Dearden Claire , Iyengar Sunil 
Published: September 2023

SummaryFor a disease initially described in 1958 as a leukaemic reticulo‐endotheliosis associated with poor outcomes, we have come a long way in our understanding of Hairy cell leukaemia. The vast majority of patients diagnosed with this rare, often diagnostically challenging, leukaemia can now expect a lifespan that is similar to the general population. This article covers some of the highlights from the last 6 decades that have led to our current understanding of this fascinating leukaemia ‐ from elucidation of its B‐cell origin to discovery of the almost universal occurrence of the BRAF V600E mutation; from the initial successes reported with splenectomy to the more recent development of targeted therapies such as Vemurafenib and Moxetumomab Pasudotox. It also pays tribute to some of the outstanding research in this field focusing particularly on the significant contributions made by the clinical and scientific community in the UK.
Acute lymphoblastic leukaemia (ALL) things come to those who wait: 60 years of progress in the treatment of adult ALL
Authors: Fielding Adele K. , Goldstone Anthony H. 
Published: September 2023

SummaryThe UK has made a well‐recognised contribution to the international effort to understand and treat acute lymphoblastic leukaemia (ALL) in adults. Work done in the UK by numerous personnel over many years has been instrumental in developing novel risk stratifications, evaluating treatment strategies for adult patients with de novo and relapsed disease and in making novel scientific contributions. The UK has championed and achieved very high levels of recruitment to clinical trials and, in particular, is known for success in large, investigator‐initiated randomised controlled trials. This historical review charts the progress of clinical research in adult ALL from its inception to the present day.
BSH 2020 Student Essay Prize ‐ ‘How are you inspired by haematology and how will you inspire others to become haematologists?’
Authors: Girard Louis‐Pierre 
Published: September 2023

SummaryAll medical personnel ponder their future career, and students perhaps more so than professionals. Indeed, there are many old and famous specialties in which we might envision ourselves forging a path, each competing for our attention. Far‐off from the clamour and glamour of venerable medicine and surgery, however, there lies younger specialties that reward quiet curiosity and stolid perseverance. Chief amongst them, in my eyes, is the speciality of haematology. Often misunderstood or otherwise unheard of, the subject of haematology and those practice it have steadily plotted a course through the maelstrom of blood disease and unremittingly turned its tide back in favour of the patients, for whom they labour. As the British Society for Haematology celebrates its 60th anniversary, the question rightly posed this year to interested students is, based on our own personal reflections, how should we continue to nourish the buds of enthusiasm and interest for this still‐blossoming specialty? In this essay, I put forth those intellectual and historical facets of haematology which have given me great inspiration, and I reflect on how we, as practitioners or as aspirants, can best cultivate the passion we feel for our subject in the hearts of others.
Retrospective first‐in‐human use of the LithoVue™ Elite ureteroscope to measure intrarenal pressure
Authors: Bhojani Naeem , Koo Kyo Chul , Bensaadi Kahina , Halawani Abdulghafour , Wong Victor KF. , Chew Ben H. 
Published: September 2023

ObjectiveTo report on our first‐in‐human experience using the LithoVue Elite™ ureteroscope (Boston Scientific Corp., Marlborough, MA, USA) to measure intrarenal pressure (IRP) during flexible ureteroscopy.Patients and MethodsA single‐arm retrospective observational analysis was performed in 50 consecutive patients undergoing ureteroscopic lithotripsy using the LithoVue Elite™ system with pressure sensing capability between April 2022 and February 2023 at two centres. A pressure bag set at 150 mmHg or hand irrigation with a 60‐mL syringe was used for irrigation and a ureteric access sheath (UAS) was placed at the physician's discretion. Median and maximum IRPs, and relative cumulative time exceeding 20, 40, 60, 80, 100, 120, 140, 160, and 200 mmHg per total procedure time were analysed. The two‐sample Mann–Whitney U‐test was used, with statistical significance set at P < 0.05.ResultsThe median (interquartile range [IQR]) patient age and body mass index (BMI) was 62.5 (46.7–68.2) years and 27.6 (23.3–32.1) kg/m2, respectively. During the median (IQR) total procedure time of 31.9 (17.4–44.9) min, the median and maximum IRPs were 28.5 (20.0–47.5) and 174.0 (133.5–266.0) mmHg, respectively. IRP remained at <60 mmHg during 92% of the procedure times. Patients with Asian ethnicity, and those without pre‐stenting or UAS use exhibited longer cumulative/total durations exceeding pre‐defined IRP cut‐off values. The smaller 10/12‐F UAS did not lower pressures as much as the 11/13‐F or 12/14‐F UAS (P < 0.001). Age, diabetes, hypertension, preoperative α‐blockade, stone size, and BMI did not show any statistically significant associations with IRP.ConclusionsThe IRP can now be routinely measured during ureteroscopy. Patients had a median IRP of 28.5 mmHg and a maximum of 174 mmHg. Using a smaller UAS (10/12 F), Asian ethnicity, and tight ureters were found to have higher IRPs.