bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precision medicine in diagnosis, prognosis, and disease monitoring of bone and soft tissue sarcomas using liquid biopsy: a systematic review
Authors: Smolle Maria Anna , Seidel Markus G. , Kashofer Karl , Liegl-Atzwanger Bernadette , Sadoghi Patrick , Müller Daniel A. , Leithner Andreas 
Published: January 2025

Abstract
Introduction
Liquid biopsy as a non-invasive method to investigate cancer biology and monitor residual disease has gained significance in clinical practice over the years. Whilst its applicability in carcinomas is well established, the low incidence and heterogeneity of bone and soft tissue sarcomas explains the less well-established knowledge considering liquid biopsy in these highly malignant mesenchymal neoplasms.

Materials and methods
A systematic literature review adhering to the PRISMA guidelines initially identified 920 studies, of whom 68 original articles could be finally included, all dealing with clinical applicability of liquid biopsy in sarcoma. Studies were discussed within two main chapters, i.e. translocation-associated and complex-karyotype sarcomas.

Results
Overall, data on clinical applicability of liquid biopsy in 2636 patients with > 10 different entities of bone and soft tissue sarcomas could be summarised. The five most frequent tumour entities included osteosarcoma (n = 602), Ewing sarcoma (n = 384), gastrointestinal stromal tumour (GIST; n = 203), rhabdomyosarcoma (n = 193), and leiomyosarcoma (n = 145). Of 11 liquid biopsy analytes, largest evidence was present for ctDNA and cfDNA, investigated in 26 and 18 studies, respectively.

Conclusions
This systematic literature review provides an extensive up-to-date overview about the current and potential future uses of different liquid biopsy modalities as diagnostic, prognostic, and disease monitoring markers in sarcoma.
Indications for the addition of a patellofemoral joint arthroplasty following a previous unicondylar knee arthroplasty– a literature review and Delphi consensus
Authors: Jones Gareth G. , Campi Stefano , von Knoch Fabian , Lunebourg Alexandre , London Nick , Barrett David , Argenson Jean-Noel 
Published: January 2025

Abstract
Introduction
The aim of this study was to establish an international consensus statement on the indications for the addition of a patellofemoral joint arthroplasty (PFJA) in patients with a unicondylar knee arthroplasty (UKA) and symptomatic progression of patellofemoral compartment osteoarthritis.

Materials and methods
A systematic review of the literature was conducted, and the results used to inform the development of a statement by an expert working group. This was then evaluated and modified, using a Delphi process, by members of the European Knee Society (EKS).

Results
Forty-nine (round one) and forty-two (round two) EKS members took part in the Delphi process, with 83% agreement on the resulting consensus statement that the indications for this procedure are: (1) a well-functioning UKA in a satisfied patient with secondary osteoarthritis progression in the patellofemoral compartment (2), symptomatic patellofemoral compartment osteoarthritis with full thickness cartilage loss affecting the lateral facet of the patellofemoral joint (3), functional ligaments, including the anterior cruciate ligament (ACL) (4), a lateral tibiofemoral compartment with no cartilage damage greater than Ahlback Grade 1 (5), knee flexion ≥ 100° and extension loss ≤ 5° and (6) older patients with increased medical co-morbidities.

Conclusions
The simple addition of a PFJA to patients with an existing UKA and progression of patellofemoral compartment osteoarthritis is an attractive option. This EKS Delphi-derived consensus statement, which reached a strong consensus, can be used by clinicians to identify patients suitable for this procedure.
Are there atypical sites of IgG4 related disease in head and neck region? Personal experience and literature review
Authors: Bertolini Melania , Buono Francesco , Galli Alice , Bagnasco Diego , Guastini Luca , Feltri Monica , Canevari Frank Rikki Mauritz 
Published: January 2025

Abstract
Purpose
Immunoglobulin G4-related disease (IgG4-RD) is a complex systemic fibroinflammatory condition with different clinical manifestations affecting multiple organ systems. Despite its rarity, the disease presents diagnostic and therapeutic challenges due to its mimicry of malignancies and other immune-mediated disorders. The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease is the current state of art to confirm the diagnosis of IgG4-RD even in the absence of histological analysis. However, this classification excludes atypical sites, focusing on the more typical ones, even in case of histological confirmation. In the ENT field, several localizations of this disease have been described.

Methods
We report two clinical cases at the Otolaryngology Unit of IRCCS San Martino Hospital, Genoa affected by IgG4-RD arising in atypical sides of the head and neck region. Additionally, we perform a clinical review of the current literature.

Discussion
The review provides an extensive overview of IgG4-RD, encompassing epidemiology, clinical manifestations, diagnostic approaches, and therapeutic strategies. We discuss the evolution of diagnostic criteria, emphasizing the necessity of interdisciplinary collaboration among clinicians, radiologists, and pathologists for accurate diagnosis. Diagnostic imaging plays a crucial role, with characteristic radiological patterns aiding in the identification of affected organs. However, definitive diagnosis often requires histopathological confirmation, highlighting the importance of biopsy in challenging cases. We also focus on the treatment of IgG4-RD which poses significant challenges, with glucocorticoids remaining the cornerstone of therapy. Emerging steroid-sparing agents such as rituximab and Dupilumab, show promising results in refractory or recurrent disease.

Conclusions
IgG4-RD is a multisystemic fibroinflammatory disease that can potentially affect any part of the body. The 2019 ACR/EULAR 3-stage classification criteria for IgG4-RD considers only a few head and neck sites. Therefore, it is of paramount importance that neurosurgeons, head and neck surgeons, and oral and maxillofacial pathologists are familiar with the clinicopathological manifestations of IgG4-RD in these sites to avoid misdiagnosis and inappropriate treatment, which can lead to a decrease in patients’ quality of life. To our knowledge, there are no risk factors or genetic predispositions. Further studies are needed to elucidate the pathophysiology of IgG4-RD with the aim of providing a targeted therapy that could spare steroid-related effects and reduce relapses.
Sleeve gastrectomy with antral resection provides more effective weight loss in patients with super obesity
Authors: Hamantepe Ahmet Tarik , Gönüllü Emre , Fırtına Gizem , İlhan Onur , Yüksel Adem , Karaman Kerem 
Published: January 2025

Abstract
Background
Obesity is a growing health issue that contributes to numerous diseases and lowers quality of life. In patients with super obesity (BMI > 50 kg/m²), bariatric surgery, particularly laparoscopic sleeve gastrectomy (LSG), is a common treatment option. However, the role of antral resection (AR) in LSG remains unclear, especially in this high-risk population. This study aims to compare the effectiveness of LSG with antral resection (LSG-AR) and LSG with antrum preservation (LSG-AP) on weight loss and postoperative complaints in patients with super obesity.

Methods
The medical records of patients with a BMI > 50 kg/m² who underwent LSG between 2016 and 2022 were retrospectively reviewed. Weight data were collected at admission, and at the first, second, and fifth-year follow-up. Patients were divided into two groups based on LSG-AR or LSG-AP procedures.

Results
Seventy-two patients were included. No significant difference was found in postoperative vomiting complaints between the groups (p = 0.67). First-year outcomes showed no significant differences in weight, BMI, or % Total Weight Loss (%TWL). However, second and fifth-year %TWL values were significantly higher in the LSG-AR group (p = 0.003 for both).

Conclusion
LSG-AR provides more effective long-term weight loss in patients with super obesity. Early postoperative vomiting complaints diminish over time, suggesting LSG-AR as a viable one-stage procedure for this patient population.
Guarding Polyominoes Under k-Hop Visibility
Authors: Filtser Omrit , Krohn Erik , Nilsson Bengt J. , Rieck Christian , Schmidt Christiane 
Published: January 2025

AbstractWe study the Art Gallery Problem under k-hop visibility in polyominoes. In this visibility model, two unit squares of a polyomino can see each other if and only if the shortest path between the respective vertices in the dual graph of the polyomino has length at most k. In this paper, we show that the VC dimension of this problem is 3 in simple polyominoes, and 4 in polyominoes with holes. Furthermore, we provide a reduction from Planar Monotone 3Sat, thereby showing that the problem is -complete even in thin polyominoes (i.e., polyominoes that do not a contain a $$2\times 2$$

2
×
2

block of cells). Complementarily, we present a linear-time 4-approximation algorithm for simple 2-thin polyominoes (which do not contain a $$3\times 3$$

3
×
3

block of cells) for all $$k\in {\mathbb {N}}$$

k
∈
N

.
Endoscopic third ventriculostomy for hydrocephalus accompanied by dural arteriovenous fistulae: a case report and literature review
Authors: Wajima Daisuke , Kamide Tomoya , Sasagawa Yasuo , Takata Sho , Misaki Kouichi , Nakada Mitsutoshi 
Published: January 2025

AbstractA 54-year-old man presented with gait disturbances, urinary incontinence, and headache for 6 months. Head computed tomography indicated several high-density mass lesions in the quadrigeminal cistern, causing occlusive hydrocephalus. Digital subtraction angiography confirmed tentorial dural arteriovenous fistulae (AVF). Transarterial embolization (TAE) achieved complete angiographic resolution. However, acute occlusive hydrocephalus worsened, necessitating endoscopic third ventriculostomy (ETV). The patient was discharged without new symptoms and no hydrocephalus recurrence at six-month follow-up. Hydrocephalus is rare in patients with dural AVF and mostly resolves spontaneously after treatment; however, if thrombosis and enlargement of the varix occur after treatment, acute occlusive hydrocephalus can develop.
The anatomy and histology of the midgut and Malpighian tubules of Copris felschei Reitter, 1892 (Coleoptera: Scarabaeidae)
Authors: Özyurt Koçakoğlu Nurcan , Ersoy Doğan Erhan , Arslan Hicret , Candan Selami 
Published: January 2025

AbstractCopris are part of the Scarabaeidae family of Coleoptera. Copris are dung beetles or coprophagous beetles. These insects are called tunnelers because they excavate channels in the substrate. They use dead organisms and non-living organic compounds as a nutrient source. By breaking down dead matter, they provide nutrients that are important to the environment and necessary for the survival of other organisms. No studies have yet examined the midgut structure and Malpighian tubules of Copris. Therefore, this study investigated the histo-anatomical structure of the midgut and Malpighian tubules of Copris felschei Reitter, 1892 (Coleoptera: Scarabaeidae) using light and scanning electron microscopy (SEM) in detail. The midgut of C. felschei represents the largest part of the alimentary canal. Muscle layers and a monolayer of cylindrical epithelium surround the midgut wall. A peritrophic membrane envelops food in the midgut lumen, and crystals were observed within the lumen. The surface of the midgut has regenerative crypts and tracheae. The Malpighian tubules are arranged in two pairs and connect proximally between the midgut and hindgut. The Malpighian tubules are composed of a single layer of cuboidal epithelium. Numerous balloon-like tracheae were observed interspersed between the midgut and Malpighian tubules. Light and SEM images of the tracheae reveal a spongy structure with hollow chambers. These findings are anticipated to advance future research and deepen our understanding of the alimentary canal in Coleoptera, particularly within the Scarabaeidae family.
Beyond traditional prognostics: integrating RAG-enhanced AtlasGPT and ChatGPT 4.0 into aneurysmal subarachnoid hemorrhage outcome prediction
Authors: Basaran Alim Emre , Güresir Agi , Knoch Hanna , Vychopen Martin , Güresir Erdem , Wach Johannes 
Published: January 2025

AbstractTo assess the predictive accuracy of advanced AI language models and established clinical scales in prognosticating outcomes for patients with aneurysmal subarachnoid hemorrhage (aSAH). This retrospective cohort study included 82 patients suffering from aSAH. We evaluated the predictive efficacy of AtlasGPT and ChatGPT 4.0 by examining the area under the curve (AUC), sensitivity, specificity, and Youden’s Index, in comparison to established clinical grading scales such as the World Federation of Neurological Surgeons (WFNS) scale, Simplified Endovascular Brain Edema Score (SEBES), and Fisher scale. This assessment focused on four endpoints: in-hospital mortality, need for decompressive hemicraniectomy, and functional outcomes at discharge and after 6-month follow-up. In-hospital mortality occurred in 22% of the cohort, and 34.1% required decompressive hemicraniectomy during treatment. At hospital discharge, 28% of patients exhibited a favorable outcome (mRS ≤ 2), which improved to 46.9% at the 6-month follow-up. Prognostication utilizing the WFNS grading scale for 30-day in-hospital survival revealed an AUC of 0.72 with 59.4% sensitivity and 83.3% specificity. AtlasGPT provided the highest diagnostic accuracy (AUC 0.80, 95% CI: 0.70–0.91) for predicting the need for decompressive hemicraniectomy, with 82.1% sensitivity and 77.8% specificity. Similarly, for discharge outcomes, the WFNS score and AtlasGPT demonstrated high prognostic values with AUCs of 0.74 and 0.75, respectively. Long-term functional outcome predictions were best indicated by the WFNS scale, with an AUC of 0.76. The study demonstrates the potential of integrating AI models such as AtlasGPT with clinical scales to enhance outcome prediction in aSAH patients. While established scales like WFNS remain reliable, AI language models show promise, particularly in predicting the necessity for surgical intervention and short-term functional outcomes. The study explored the use of advanced AI language models, AtlasGPT and ChatGPT 4.0, to predict outcomes for patients with aneurysmal subarachnoid hemorrhage (aSAH). It found that AtlasGPT provided the highest diagnostic accuracy for predicting the need for decompressive hemicraniectomy, outperforming traditional clinical scales, while both AI models showed promise in enhancing outcome predictions when integrated with established clinical assessment tools.
Phenacoscorpius trispinis, a new species of scorpionfish (Teleostei: Scorpaenidae) from Sagami Bay, Japan
Authors: Matsumoto Tatsuya , Motomura Hiroyuki 
Published: January 2025

Abstract

Phenacoscorpius trispinis (Teleostei: Scorpaenidae), a new species of scorpionfish is described from Sagami Bay, Japan. The new species is characterized by the following combination of characteristics: pectoral-fin rays 16 or 17, middle rays branched; pored lateral-line scales 4; upper gill rakers 6, lower gill rakers 14 (10 and 4 on ceratobranchial and hypobranchial, respectively), total gill rakers 20; no slit behind last gill arch; palatine teeth absent; anterodorsal and lateral lacrimal spines present; second preopercular spine smaller than third or fourth spines; nuchal and parietal spines distinct; head length 45.2% of SL (standard length); body depth 38.1% of SL; head width 17.2% of SL; snout length 11.2% of SL; maxillary depth 7.6% of SL; postorbital length 21.2% of SL; first dorsal-fin spine length 6.8% of SL; second dorsal-fin spine length 13.6% of SL; pelvic-fin spine length 19.9% of SL; longest pelvic-fin ray 23.2% of SL; longest pectoral-fin ray 39.0% of SL; caudal-fin length 25.3% of SL; caudal-peduncle length 17.2% of SL. A molecular genetic analysis based on the mitochondrial marker Cytochrome c oxidase subunit I showed that the new species formed a clade distinct from congeneric species. New standard Japanese names are proposed for both the genus Phenacoscorpius and the new species.
Captive-introduced tortoises in wild populations: can we identify them by shell morphology?
Authors: Semaha Mohamed Jaouhar , Rodríguez-Caro Roberto C. , Giménez Andrés , Fahd Soumia , Graciá Eva 
Published: January 2025

Abstract
Direct exploitation and wildlife trade pose significant threats to global biodiversity, particularly impacting reptiles, such as tortoises, which are highly vulnerable. Moreover, the releases of captive-held animals into the wild can lead to potential negative consequences, including genetic introgression, disease transmission, and parasite spread. Therefore, diagnostic assessments are essential to evaluate the impact of release practices. In this study, we analyzed the shell morphology of Testudo graeca tortoises to assess the effectiveness of morphological analysis in identifying captive-introduced tortoises and quantifying tortoise releases in SE Spain. Despite being illegal, the cultural tradition of keeping and breeding tortoises at home persists in this region. Principal component analyses identified significant morphological differences between captive and wild tortoises. Captive tortoises generally exhibited larger shell sizes and greater morphological variability compared to wild tortoises. Accordingly, linear discriminant analyses accurately identified approximately 99% of wild tortoises, but the identification of captive tortoises was only 50% accurate because some captive tortoises show shell morphologies identical to wild ones. These results likely reflect the diverse origins and growth conditions of captive tortoises. Although this is likely an underestimation, our approach classified 7% of 125 wildlife tortoises across 13 natural sites such as captive-introduced tortoises. These findings highlight the potential impact of tortoise releases in wild populations and underscore the value of morphological analyses as an initial tool for diagnosing such impacts. Furthermore, integrating genetic and isotopic methods could further enhance the precision of these assessments.
Forecasting China’s Short-Term Energy Futures Price Using a Novel Secondary Decomposition-Optimized System
Authors: Jiang Zhe , Zhang Zili , Zhang Lin 
Published: January 2025

AbstractEnergy futures price forecasting is challenging due to the nonlinear and fluctuant characteristics. Existing literature mainly uses decomposition and ensemble method which neglects the intrinsic mode function obtained by the first decomposition could be irregular and thus reduces the prediction accuracy. To fill the research gap, a novel secondary decomposition-optimized-KELM-ensemble forecasting system is proposed to perform short-term forecasting in this study, which synthesizes two-stage data decomposition method, Sparrow search optimization algorithm, and extreme learning machine with kernel. We test the method with two energy futures prices in China, demonstrating that both one-day and three-day ahead forecasting results obtained are more accurate and stable compared to existing models in the literature, such as BPNN (improved by 58.42% on one-day ahead and 56.44% on three-day ahead by MAE) and KELM (improved by 56.40% on one-day ahead and 49.04% on three-day ahead by MAE). Therefore, the forecasting system introduced in this paper can provide useful implications for both policy makers and financial practitioners in the energy sector.
Evaluation of Wildland Fire Detection Methods Using Expert Input
Authors: Björck Johan , McNamee Margaret 
Published: January 2025

AbstractRecently the Intergovernmental Panel on Climate Change released their 6th Assessment reports which confirm that the impact of climate change is visible, e.g. through an increased weather volatility leading both to hotter drier weather and increased flooding in some regions globally. One clear example of this is the increased prevalence of wildfires in recent years and increasing wildfire potential in the future in some regions. Sweden is in the northern most part of Europe and has the highest forest density in the European Union. In total, nearly 17 percent of all forests in Europe are located in Sweden. Even in a global sense, Sweden has extensive forestry, and provides 10 percent of the sawn timber, pulp and paper that is traded on the global market. Given these preconditions, in 2020 the Swedish Civil Contingencies Agency (MSB) identified the need to investigate the conditions for current and possible future detection methods for wildfires in Sweden. An overview of common current methods was made and review of these methods was conducted through interviews with national experts. The expert evaluation indicated an opportunity to build wildfire detection in Sweden based on weather radar, radar/satellite combinations, and/or airborne radar. The development of such detection systems could repurpose existing infrastructure and reduce the overall investment needs, implying that Sweden could adopt such methods rapidly provided there is sufficient political will. The methodology shows the advantage of using expert input to identify appropriate technical measures for further research investments given limited resources.
Effect of Probiotics on the Symptomatology of Autism Spectrum Disorder and/or Attention Deficit/Hyperactivity Disorder in Children and Adolescents: Pilot Study
Authors: Rojo-Marticella Meritxell , Arija Victoria , Canals-Sans Josefa 
Published: January 2025

Abstract
The aim of this study is to investigate the impact of using probiotics with strains related to dopamine and gamma-aminobutyric acid production on clinical features of autism spectrum disorder (ASD) and/or attention deficit/hyperactivity disorder (ADHD). This randomized, controlled trial involved 38 children with ADHD and 42 children with ASD, aged 5–16 years, who received probiotics (Lactiplantibacillus plantarum and Levilactobacillus brevis 109/cfu/daily) or placebo for 12 weeks. Parent-reported symptoms were assessed using Conners' 3rd-Ed and the Social Responsiveness Scale Test, 2nd-Ed (SRS-2), and children completed the Conners Continuous Performance Test, 3rd-Ed (CPT 3) or Conners Kiddie CPT, 2nd-Ed (K-CPT 2). Executive functions, quality of life and sleep patterns were also parent-assessed. Intention-to-treat analyses, controlling for sociodemographic and nutritional covariates, revealed no significant inter-group differences in parent-reported or neuropsychological data after the probiotic intervention. However, age-stratified analyses showed improved hyperactivity-impulsivity symptoms in younger children with ASD (Cohen’s d = 1.245) and ADHD (Cohen’s d = 0.692). Intra-group analyses supported these findings in the aforementioned age and intervention group for both diagnoses. An improvement in impulsivity for children with ASD was also observed in the intra-group analysis of the CPT commissions scores (probiotic: p = 0.001, Cohen’s d = -1.216; placebo: p = 0.013, Cohen’s d = -0.721). A better comfort score (quality of life) was shown in children with ASD (probiotic: p = 0.010, Cohen’s d = 0.722; placebo: p = 0.099, Cohen’s d = 0.456). The probiotics used, may improve hyperactivity-impulsivity in children with ASD or/and ADHD and quality of life in children with ASD. Further research is warranted to explore probiotics as an adjunctive therapeutic intervention for NDs.
Trial registration: clinicaltrials.gov Identifier: NCT05167110.