bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical diversity and main directions of medical rehabilitation of dorsopathies of cervical-thoracic localization
Authors: Yakovlev E. V. , Zhivolupov S. A. , Gnevyshev E. N. , Achkasov E. E. , Butko D. Yu. , Vetrova T. V. , Davydov A. T. 
Published: August 2023

Introduction. The high prevalence and increase in cases of seeking medical help for pain in dorsopathies determines the relevance of this problem. Among all the conditions included in the study of health care costs, non-specific musculoskeletal back pain ranks first in the world. A special place belongs to cervicothoracic dorsopathy (CTD), which are most common in developed countries and are characterized by a variety of clinical forms. In our opinion, a comprehensive method of treating CTD with the mandatory use of non-drug methods of therapy is the most optimal.Aim. Determination of the relationship between the pathogenetic form of CTD (verification of pain triggers) and a personalized method of treating patients, containing a combination of drug therapy and a rehabilitation complex of physiotherapeutic, psychotherapeutic effects.Materials and methods. Patients with CTD were included in the study. Neurological status assessment and biomechanical tests were carried out for accurate clinical verification of pathogenetic forms of CTD. Depending on the choice of treatment, respondents were stratified into comparable groups. The main group included patients to whom the original technique was applied, which implied a combination of drug therapy, a complex of rehabilitation physiotherapy and psychotherapeutic effects (n = 155), the control group (n = 65) – respondents who received a standard course of therapy. The statistical analysis included a comparative assessment of the intensity of pain syndrome, static-dynamic and reflex disorders before and after therapy.Results. Both methods have shown their effectiveness. The original technique more effectively reduced the intensity of pain syndrome, reduced the frequency of reflex disorders (p < 0.05), significantly reduced static-dynamic disorders in all subgroups (p < 0.05), while the standard significantly reduced them only in the subgroup with uncomplicated forms of CTD, without achieving a therapeutic effect in complicated CTD.Conclusion. The original method of therapy of patients with HCG has confirmed its effectiveness.
Skeletal and muscular manifestations of post-COVID syndrome: literature review
Authors: Minigalina K. M. , Gantseva Kh. Kh. , Sadretdinova L. D. , Golubyatnikov V. B. , Akhiiarova K. E. , Tyurin A. V. 
Published: August 2023

The 2019 outbreak of a novel coronavirus infection in Wuhan City has resulted in a pandemic that has not only brought about global social change, but has also been a challenge for the entire medical community. The accumulation of material on this disease has revealed the multisystemic nature of internal organ damage with the development of new associated conditions, particularly those related to immunopathology and rheumatologic diseases. This review describes the literature on musculoskeletal symptoms during different periods of new-onset coronavirus infection (COVID-19). The paper defines the terms post-COVID syndrome and Long COVID, and describes clinical observations and the most common symptoms in adults and children. Clinical cases of joint syndrome are described in patients who have had a new coronavirus infection and no history of rheumatologic disease. Possible molecular pathogenesis of autoimmunity activation (cellular and humoral immune response as well as direct cytotoxic effect of the virus) both in acute period of coronavirus infection as well as during recuperation is also considered. Literature analysis of peculiarities of course of COVID-19 in patients with rheumatological diseases was carried out, in particular the risk of infection, its severe course and unfavourable outcome. In general, according to the analysis of the literature, musculoskeletal lesions occur more frequently between 3 and 10 weeks after the end of the acute stage of infection, most often manifested by muscle and joint pain, while the incidence of true reactive arthritis associated with COVID-19 is low. The pathogenesis of musculoskeletal damage requires further investigation and patients should be followed up for a longer period of time.
Şahin Giray Dönemi’ndeki İsyanlarda Kendi Anlatımlarıyla Karaylar (1777-1783) “Öfke Dininceye Dek Tekrar Saklanmalıyız”
Authors: ÇOLAK Deniz , DERİN PAŞAOĞLU Derya 
Published: August 2023

Küçük Kaynarca Antlaşması (1774) ile müstakil hanlık statüsü kazanan Kırım Hanlığı 1783 yılındaki Rus ilhakına değin iç çatışmalarla mücadele etmiştir. Kırım Yarımadasının çok etnikli ve çok dinli yapısı bu mücadeleler sırasında oldukça ilgi çekici hikâyelerin ortaya çıkmasına zemin hazırlamıştır. İsyanlar ve iç savaşın sürdüğü kargaşa ortamından etkilenen çok dinli Kırım toplumu içinde yaşadıkları acılar ve bunları kaydetmeleri açısından Karaylar öne çıkmaktadır. Bu bağlamda çalışmanın konusunu da bahsi geçen Karay toplumunun hikâyeleri oluşturmaktadır.
Müstakil Kırım Hanlığı döneminde farklı etnik ve dini gruplar arasında varoluş mücadelesi vermek zorunda kalan ve bu gruplar arasında sıkışan Karay cemaatinin geride bıraktığı kayıtlardan yola çıkılarak hazırlanan çalışmada, isyanlar sırasında yaşanan dramatik olaylar ele alınmış ve bunların nedenleri üzerinde tartışılmıştır. Mevcut literatürde, Şahin Giray dönemindeki isyanlar siyasi olarak ele alınmakla birlikte isyanın toplumsal zemindeki karşılığı ihmal edilmiş bulunmaktadır. Bu eksiklikten yola çıkılarak mevcut çağdaş kaynaklar ışığında Kırımlı Karaylar incelenerek literatüre kazandırılmaya çalışılmıştır.
RELIABILITY AND VALIDITY OF THE TURKISH VERSION OF THE GRADED CHRONIC PAIN SCALE 2.0
Authors: YOL AĞIL Hüsniye , MUAMMER Rasmi 
Published: August 2023

Purpose: To investigate the translation and cultural adaptation, the reliability and validity of the Turkish version of the Graded Chronic Pain Scale (GCPS) 2.0.
Methods: The study was an observational and cross-sectional study translated and adapted into Turkish according to the Beaton protocol. Data was collected from eighty participants diagnosed with chronic low back pain (LBP) by a physician. Due to the pandemic, the scales were sent to patients via online form. Reliability was assessed using the test-retest method, parallel form method, and internal consistency. Validity was assessed using face, content, and construct validity analyses.
Results: Cronbach's alpha was calculated as 0.89 to determine internal consistency. The intraclass correlation coefficient (ICC) was found to be 0.92 for the GCPS 2.0 total. Statisticaly significant correlation was found betweeen the GCPS 2.0 and the Oswestry Low Back Pain Disability Index (ODI) ( r = 0.759 p = 0.001) and between the GCPS 2.0 and the Roland-Morris Disability Questionnaire (RMDQ) (r = 0.777 p = 0.001). Factor analysis revealed a 2-factor structure.
Conclusion: The Turkish version of the GCPS 2.0 is a valid and reliable measurement tool for patients with chronic LBP.
Evaluating the effects of different pollution reduction scenarios on the total phosphorus concentration of a mountainous river basin in southwest China using SWAT model: a case study of the Donghe River in Baoshan, Yunnan
Authors: Wang Yongjian , Zhu Changjun , Hu Chunming , Hao Wenlong 
Published: August 2023

Abstract

Water quality has become a significant concern in many river basins in China due to both point and non-point source pollution. The SWAT model assessed pollution reduction scenarios and their effects on Donghe River basin water quality in southwest China. The calibrated model evaluated existing point and non-point emissions. Three schemes reduced point sources by 30, 60, and 90% and non-point sources by 25, 50, and 75%, respectively. Simulations analyzed annual and monthly total phosphorus (TP) concentrations under the scenarios. Results showed that the scenarios effectively improved water quality, meeting Class IV TP standards annually. However, TP exceeded standards in dry months (January–April, December) under all scenarios. A certain degree of negative correlation (R = −0.52, P = 0.11) between TP and rainfall suggests rainfall that influences TP. Comprehensive measures are needed to achieve standards year-round. In summary, the study found that reducing emissions improved Donghe water quality overall but more work is required to meet standards during dry periods. Rainfall correlates with and may affect TP. The work emphasizes implementing comprehensive approaches for year-round water quality improvements in the basin.
Áreas de risco a alagamento e inundação na foz do rio Cachoeira, em Ilhéus (Bahia – Brasil)
Authors: Martinez Tolentino Gabriel , De Amorim Silva Vinícius , Dos Santos Lisboa Gerson , Soares Teles Santos Marcelo , Ribeiro de Sena Sival 
Published: August 2023

Fenômenos hidrometereológicos têm sido cada vez mais recorrentes por conta do crescimento urbano, visto que este impermeabiliza o solo, intensifica o escoamento superficial e aumenta o acúmulo de água na superfície. Esse trabalho objetivou mapear as áreas de risco a inundações e alagamentos na foz do Rio Cachoeira em Ilhéus – BA, onde em seu entorno estão localizados vários bairros que são atingidos por esses fenômenos naturais frequentemente. Para tal, realizou-se uma análise espacial multicritério pelo método Analytic Hierarchy Process (AHP), onde combinou-se covariáveis ambientais por Álgebra de mapas no software QGIS 3.26. O RStudio foi utilizado para elaborar gráficos. Foi possível identificar com os mapas e gráficos como cada covariável ambiental e suas respectivas classes estão distribuídas em cada classe de risco. Os resultados apontaram que mais de 75% da área está sujeita a riscos Moderado, Alto e Muito Alto, e que a Área Urbana está altamente inserida em zonas de Risco Muito Alto, onde predominam relevo plano e manguezais. As informações geradas podem ser utilizadas pela Secretaria de Defesa Civil para nortear ações que minimizem os impactos negativos causados pelas inundações e alagamentos, como exemplo, planos de ocupação, recuperação da mata ciliar, obras de drenagem, dentre outras alternativas.
Palavras-chave: Análise Espacial; Análise Multicritério; Desastres naturais.
A Golden Shield: The Protective Role of Curcumin against Liver
Fibrosis
Authors: Abolfazli Sajad , Butler Alexandra E. , Jamialahmadi Tannaz , Sahebkar Amirhossein 
Published: August 2023

Abstract:
Several chronic liver injuries can result in liver fibrosis, a wound-healing response defined by an excessive buildup of diffuse extracellular matrix (ECM). Liver fibrosis may progress to liver cirrhosis, liver failure, or hepatocellular carcinoma. Many
cellular routes are implicated in the fibrosis process; however, hepatic stellate cells appear to be the main cell type involved. Curcumin, a polyphenolic substance extracted
from the Curcuma longa plant, has a diversity of pharmacologic impacts, including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic actions. The anti-fibrotic property of curcumin is less clear, but curcumin's ability to influence inflammatory cytokines, inflammatory pathways, the expression of pro-apoptotic (up-regulated) and anti-apoptotic (down-regulated) proteins, and its ability to lower oxidative stress likely underlie its anti-fibrotic properties. In this review, we investigate and analyze the impact of
curcumin on several disorders that lead to liver fibrosis, and discuss the therapeutic applications of curcumin for these disorders.
Graphene Oxide/Reduced Graphene Oxide Nanomaterials for Targeted
Photothermal Cancer Therapy
Authors: Sahoo Shraban Kumar , Dilnawaz Fahima 
Published: August 2023

Abstract:
A combination of cancer therapy (hyperthermia with other therapies) holds tremendous
potential for therapeutic improvement. Conventional methods of inducing hyperthermia
are incapable of limiting a high-temperature increase at the tumor location while also
preserving unexposed healthy tissues. Different materials available are not suitable for the
combined application of hyperthermia and photothermal therapy (PTT). The use of carbonbased
nanomaterials for cancer therapy has increased rapidly due to their ability to transport
various anticancer drugs and to function as a photothermal agent. In this regard, the graphene
family of 2D carbon nanomaterial graphene oxide (GO) and reduced graphene oxide (rGO)
has emerged as a promising candidate for cancer PTT due to its excellent photothermal conversion
in the near-infrared range, large specific surface area for drug loading, and scope for
functionalization with functional groups/ molecules such as photosensitizers, siRNA, ligands, and so on with no
cumulative toxicity. The availability of functional groups such as hydroxyls, epoxides, and carbonyls on GO
groups, renders flexible modification leading to biocompatibility, facilitating it for an ideal drug delivery vector. In
the present review, recent advances in combinational PTT providing synergistic benefits of multiple modalities are
discussed.
Expanded Therapeutic Applications of Holarrhena Antidysenterica:
A Review
Authors: Tiwari Ruchi , Khatri Charul , Tyagi Lalit Kumar , Tiwari Gaurav 
Published: August 2023

Background:
The use of medicinal plants as a rich resource of therapeutic agents in the
treatment and prevention of diseases & ailments has been recognized for millennia and is highly
regarded worldwide. Holarrhena antidysenterica (H. antidysenterica), also called kurchi, or kutaj,
has been utilized since the dawn of time, Apocynaceae member, also known as H. pubescens, is
praised for the medicinal uses of its stem bark, leaves, and seeds in Ayurveda.

Objective:
The study concentrated on aggregate information regarding H. antidysenterica's therapeutic
effects. The purpose of the study was to compile pharmacological activities of H. antidysentrica
seeds.

Methods:
Regardless of its broad variety of biological and possible therapeutic uses, there has been
increasing concern regarding the use of H. antidysenterica.

Result:
Various phytochemicals have been extracted from H. antidysenterica in recent years and
have demonstrated typical pharmacological properties, including antibacterial, anti-diarrhoeal,
anti-diabetic, anti-oxidant, anti-urolithic, and anti-inflammatory activity.

Conclusion:
This review paper investigated the in-depth description and pharmacological properties
of the plant, which produced significant findings on the chemical components present and also
verified the traditionally claimed properties associated with the plant.
Conjugation of Doxorubicin and Carbon-based-nanostructures for Drug Delivery against HT-29 Colon Cancer Cells
Authors: Aghdam Kaveh Jafari , Sabeti Bahare , Chekin Fereshteh , Mashreghi Maral 
Published: August 2023

Background:
A drug delivery system is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Such systems release the drugs at specific amounts in a specific site. The carbon based-nanomaterials have been actively used as drug carriers to treat various cancer.

Objective:
This study aimed to evaluate the cytotoxic effects of DOX-GO, DOX-OMC and DOX-CNT in colon cancer cells (HT29).

Methods:
We reported platforms based on graphene oxide (GO), ordered mesoporous carbon (OMC) and carbon nanotubes (CNT) to conjugate with doxorubicin (DOX). The conjugation of DOX with carbon nanomaterial was investigated by UV-Vis spectroscopy, ﬁeld emission scanning electron microscope (FE-SEM) and cyclic voltammetry (CV) methods.

Results:
We showed that graphene oxide was a highly eﬃcient matrix. Efficient loading of DOX, 89%, 78%, and 73.5% at pH 7.0 was seen onto GO, OMC and CNT, respectively. Upon pH 4. 0 after 15 h, 69%, 61% and 61% of DOX could be released from the DOX-GO, DOX-OMC and DOX-CNT, respectively, which illustrated the significant benefits of the developed approach for carbon nanomaterial applications. In vitro cytotoxicity analysis showed greater cytotoxicity of DOX/GO, DOX/OMC and DOX/CNT in comparison with GO, OMC and CNT against HT29 colon cancer cells with cell viability of 22%, 40% and 44% after 48 h for DOX-GO, DOX-OMC and DOX-CNT, respectively.

Conclusion:
The nanohybrids based on DOX-carbon nanomaterial, because of their unique physical and chemical properties, will remarkably enhance the anti-cancer activity.
Drug Repositioning Using Computer-aided Drug Design (CADD)
Authors: Rawat Sona , Subramaniam Kanmani , Subramanian Selva Kumar , Subbarayan Saravanan , Dhanabalan Subramanian , Chidambaram Sashik Kumar Madurai , Stalin Balasubramaniam , Roy Arpita , Nagaprasad Nagaraj , Aruna Mahalingam , Tesfaye Jule Leta , Badassa Bayissa , Krishnaraj Ramaswamy 
Published: August 2023

Abstract:
Drug repositioning is a method of using authorized drugs for other unusually complex
diseases. Compared to new drug development, this method is fast, low in cost, and effective.
Through the use of outstanding bioinformatics tools, such as computer-aided drug design
(CADD), computer strategies play a vital role in the re-transformation of drugs. The use of
CADD's special strategy for target-based drug reuse is the most promising method, and its realization
rate is high. In this review article, we have particularly focused on understanding the various
technologies of CADD and the use of computer-aided drug design for target-based drug reuse,
taking COVID-19 and cancer as examples. Finally, it is concluded that CADD technology is accelerating
the development of repurposed drugs due to its many advantages, and there are many
facts to prove that the new ligand-targeting strategy is a beneficial method and that it will gain
momentum with the development of technology.
The Natural Product Oridonin as an Anticancer Agent: Current
Achievements and Problems
Authors: Hu Xiangyan , Huang Sisi , Ye Shiying , Jiang Jinhuan 
Published: August 2023

Abstract:
Oridonin, an active diterpenoid isolated from traditional Chinese herbal medicine, has
received a rising attention for its remarkable roles in cancer therapy. In recent years, increasing
evidences have revealed that oridonin inhibits the occurrence and development of tumor cells
through multiple mechanisms, including induction of apoptosis and autophagy, cell cycle arrest,
and inhibition of angiogenesis as well as migration and invasion. In addition, several molecular
signal targets have been identified, including ROS, EGFR, NF-κB, PI3K/Akt, and MAPK. In this
paper, we review considerable knowledge about the molecular mechanisms and signal targets of
oridonin, which has been studied in recent years. It is expected that oridonin may be developed as
a novel anti-tumor herbal medicine in human cancer treatment.
Silica-supported Active Ni Nanocatalyst for Wittig Reaction
Authors: Srivastava Vivek 
Published: August 2023

Abstract:
The preparation and characterization of SBA-15 supported Ni catalysts with varying metal
loading (1, 2, and 3% by weight) was carried out using the impregnation technique, followed by a rigorous
characterization using advanced analytical techniques. The catalytic performance of the synthesized
catalysts was evaluated for the Wittig-type olefination reaction, and it was found that the SBA-
15-3Ni catalyst exhibited superior activity for this reaction under mild reaction conditions (70°C and 1
hour). The corresponding stilbenes were obtained in good yield, although with low to average diastereoselectivity.
An important feature of this protocol is that the proposed methodology is especially
efficient for the synthesis of stilbenes since no additives are required to serve as a hydrogen acceptor.
Moreover, the new catalytic system was successfully employed for the synthesis of polymethoxylated
and polyhydroxylated stilbenes, including resveratrol and DMU-212, with high yield and easy product
isolation. A key advantage of this protocol is that the catalysts can be reused for up to 5 runs without
significant loss in catalytic activity, which makes this approach highly sustainable and cost-effective.
Additionally, the ligand-free approach proposed in this study is an added advantage, which makes it
more attractive for large-scale synthesis of biologically active compounds.
SARS-CoV-2 Encephalitis versus Influenza Encephalitis: More Similarities than Differences
Authors: Hon Kam L.E. , Leung Alexander K.C. , Tan Yok W. , Leung Karen K.Y. , Chan Paul K.S. 
Published: August 2023

Background:
From time to time, physicians face challenging diagnostic and therapeutic issues concerning the acute management of children with viral encephalitis.

Objective:
The aim of this article is to provide an updated narrative review on the similarities and differences between SARS-CoV-2 and influenza encephalitis.

Methods:
A PubMed search was performed with the function “Clinical Queries” using the key terms “SARS-CoV-2” OR “Influenza” AND “Encephalitis”. The search strategy included meta-analyses, clinical trials, randomized controlled trials, reviews and observational studies. The search was restricted to the English literature and pediatric population. This article compares similarities and contrasts between SARS-CoV-2 and influenza-associated encephalitis.

Results:
Encephalitis is an uncommon manifestation of both influenza and SARS-CoV-2. Both vi-ruses are associated with fever and respiratory symptoms. However, SARS-CoV-2 patients may on-ly have mild symptoms or be asymptomatic as silent carriers, rendering the disease spread difficult to control. Influenza patients usually have more severe symptomatology and are often bed bound for several days limiting its spread. Influenza is associated with seasonal and annual outbreaks, whereas SARS-CoV-2 has become endemic. Complications of encephalitis are rare in both viral infections but, when present, may carry serious morbidity and mortality. Many long-term sequelae of COVID-19 infections (long COVID-19) have been described but not with influenza infections. Mortality as-sociated with encephalitis appears higher with influenza than with SARS-CoV-2. Prophylaxis by immunization is available for both influenza and SARS-CoV-2. Specific efficacious antivirals are also available with oseltamivir for influenza and nirmatrelvir/ritonavir for SARS-CoV-2. Steroids are indicated with more severe SARS-CoV-2 but their role is not distinct in influenza disease.

Conclusion:
Encephalitis is a rare complication of influenza and SARS-CoV-2 infections. Both carry significant morbidity and mortality. Efficacious vaccines for prophylaxis and antivirals for treatment are available for both viruses.