bluuebunny/crossref_metadata_2025_split huggingface dataset:
Icex: Advances in the automatic extraction and volume calculation of cranial cavities
Authors: Buzi Costantino , Profico Antonio , Liang Ce , Khonsari Roman H. , O'Higgins Paul , Moazen Mehran , Harvati Katerina 
Published: February 2023

AbstractThe use of non‐destructive approaches for digital acquisition (e.g. computerised tomography—CT) allows detailed qualitative and quantitative study of internal structures of skeletal material. Here, we present a new R‐based software tool, Icex, applicable to the study of the sizes and shapes of skeletal cavities and fossae in 3D digital images. Traditional methods of volume extraction involve the manual labelling (i.e. segmentation) of the areas of interest on each section of the image stack. This is time‐consuming, error‐prone and challenging to apply to complex cavities. Icex facilitates rapid quantification of such structures. We describe and detail its application to the isolation and calculation of volumes of various cranial cavities. The R tool is used here to automatically extract the orbital volumes, the paranasal sinuses, the nasal cavity and the upper oral volumes, based on the coordinates of 18 cranial anatomical points used to define their limits, from 3D cranial surface meshes obtained by segmenting CT scans. Icex includes an algorithm (Icv) for the calculation of volumes by defining a 3D convex hull of the extracted cavity. We demonstrate the use of Icex on an ontogenetic sample (0–19 years) of modern humans and on the fossil hominin crania Kabwe (Broken Hill) 1, Gibraltar (Forbes' Quarry) and Guattari 1. We also test the tool on three species of non‐human primates. In the modern human subsample, Icex allowed us to perform a preliminary analysis on the absolute and relative expansion of cranial sinuses and pneumatisations during growth. The performance of Icex, applied to diverse crania, shows the potential for an extensive evaluation of the developmental and/or evolutionary significance of hollow cranial structures. Furthermore, being open source, Icex is a fully customisable tool, easily applicable to other taxa and skeletal regions.
Factors influencing the delivery of nutritional care by nurses for hospitalised medical patients with malnutrition; a qualitative study
Authors: Van Den Berg Gerda , Vermeulen Hester , Conroy Tiffany , Van Noort Harm , De Van Der Schueren Marian , Huisman‐de Waal Getty 
Published: February 2023

AbstractObjectivesTo describe an insight into nursing nutritional care delivery in the hospital from the perspectives of observed nursing care and an exploration of multidisciplinary attitudes and experiences with patient participation in nutritional care.BackgroundThe prevalence of malnutrition in hospitalised patients continues to be high. Nurses' essential role in the identification and treatment of malnutrition is an important aspect of the fundamentals of care. Nurses have a key role in providing optimal nutritional care in the hospital. A systematic nursing approach, combined with an active role for patients, is required to effectively counteract malnutrition.DesignA multicentre qualitative study using ethnographic observations and focus groups.MethodsDirect observation of nutritional care was conducted on two nursing wards; nurses and inpatients were observed; and data were thematically analysed based on the fundamentals of care framework. Subsequently, six focus groups were held on three nursing wards with nurses, dietitians and nutrition assistants (n = 34). Data were analysed using open, axial and selective coding. The COREQ guidelines were used for reporting the study.ResultsDuring 54 days, representing 183 h, 39 nurses were observed in two medical wards. Three activities in nutritional care delivery were identified from observing nurses and patients: (1) screening and assessment/at‐risk determination, (2) nutritional care plans and (3) monitoring and evaluating outcomes and transition‐of‐care planning. In addition, the focus groups identified barriers, facilitators, needs and expectations for optimal nursing nutritional care delivery.ConclusionsThis study provides an understanding of the difficulties in the delivery of nursing nutritional care. Patient participation in the nutritional care process is rare. Evidence‐based strategies are required to improve the knowledge and skills of nurses and patients to participate in (mal)nutrition care.RelevanceThe findings of this study are used for the development of a nursing nutrition intervention to optimise patient participation in (mal)nutrition care.Patient or public contributionDuring the study, patients were not involved with the observations of care and/or with the interviews; the researchers observed the nutritional care delivery at medical wards acting as passive participants. Nurses, nutrition assistants and dietitians were after the focus groups asked for feedback on the transcripts of the interviews.
Social embeddedness and supply chains: Doing business with friends versus making friends in business
Authors: Ding Haoyuan , Hu Yichuan , Jiang Han , Wu Jing , Zhang Yu 
Published: February 2023

Network literature has widely documented that the managerial ties between corporate leaders in two firms can promote their economic exchanges in supply chains, that is, social embeddedness. In this study, we strive to advance this line of inquiry by exploring the dynamics of such socially embedded supply chains, examining whether and when the dissolution of managerial ties between two firms would cause the subsequent termination of their supplier–buyer exchanges. We address this question by distinguishing two types of socially embedded supply chains based on their different relational origins: business‐with‐friend links in which the managerial ties precede the supply chains, and friend‐in‐business links in which the supplier–buyer exchanges precede the managerial ties. We posit that the managerial tie dissolution has a negligible effect on the subsequent termination of supply chains in business‐with‐friend links. In contrast, in friend‐in‐business links, the dissolution of managerial ties between two firms is associated with a significantly higher likelihood for their supplier–buyer exchanges to dissolve afterward. We find strong empirical evidence for the above propositions using a nuanced data set that integrates the managerial tie information and the supply chain data. In sum, we show that socially embedded supply chains with different origins (“doing business with friends” vs. “making friends in business”) would have distinct patterns of evolution and dissolution.
Evaluation of right atrial function by two-dimensional echocardiography and strain imaging in patients with RCA CTO recanalization
Authors: Blessing Recha , Drosos Ioannis , Münzel Thomas , Wenzel Philip , Gori Tommaso , Dimitriadis Zisis 
Published: February 2023

Abstract
Objectives
The right heart is mainly supplied with blood by the right coronary artery (RCA). The impact of RCA chronic total occlusion (CTO) on the function of the right heart [right atrium (RA) and ventricle (RV)] and whether successful recanalization of a RCA CTO improves the function of the right heart is not clearly understood yet. We aimed to evaluate right atrial function after recanalization of the RCA using transthoracic echocardiography with additional strain imaging.

Methods and results
Fifty-five patients undergoing RCA CTO recanalization at the University Medical Center of Mainz were included in the study. Right atrial strain was assessed before and 6 months after successful CTO revascularization. The median age of the total collective was 66 (50–90) years. We did not find difference in our analysis of RA Volume (p 0.086), RA area (p 0.093), RA major dimension (p 0.32) and RA minor dimension (p 0.139) at baseline and follow-up. Mean RA reservoir strain at baseline was 30.9% (21.1–43.0) vs. 33.4% (20.7–47.7) at follow up (p < 0.001). Mean RA conduit strain was − 17.5% (− 10.7–(− 29.7)) at baseline vs. − 18.2% (− 9.6–(− 31.7)) at follow-up (p = 0.346). Mean RA contraction strain was − 12.9% (− 8.0- (− 21.3)) at baseline vs. − 15.5% (− 8.7–(− 26.6)) at follow-up (p < 0.001).

Conclusion
Right atrial function was altered in patients with RCA CTO. Successful revascularisation of an RCA CTO improved RA function assessed by strain imaging at follow-up.
Developing a predictive nomogram for colposcopists: a retrospective, multicenter study of cervical precancer identification in China
Authors: Xue Peng , Seery Samuel , Wang Sumeng , Jiang Yu , Qiao Youlin 
Published: February 2023

Abstract
Background
Colposcopic examination with biopsy is the standard procedure for referrals with abnormal cervical cancer screening results; however, the decision to biopsy is controvertible. Having a predictive model may help to improve high-grade squamous intraepithelial lesion or worse (HSIL+) predictions which could reduce unnecessary testing and protecting women from unnecessary harm.

Methods
This retrospective multicenter study involved 5,854 patients identified through colposcopy databases. Cases were randomly assigned to a training set for development or to an internal validation set for performance assessment and comparability testing. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to reduce the number of candidate predictors and select statistically significant factors. Multivariable logistic regression was then used to establish a predictive model which generates risk scores for developing HSIL+. The predictive model is presented as a nomogram and was assessed for discriminability, and with calibration and decision curves. The model was externally validated with 472 consecutive patients and compared to 422 other patients from two additional hospitals.

Results
The final predictive model included age, cytology results, human papillomavirus status, transformation zone types, colposcopic impressions, and size of lesion area. The model had good overall discrimination when predicting HSIL + risk, which was internally validated (Area Under the Curve [AUC] of 0.92 (95%CI 0.90–0.94)). External validation found an AUC of 0.91 (95%CI 0.88–0.94) across the consecutive sample, and 0.88 (95%CI 0.84–0.93) across the comparative sample. Calibration suggested good coherence between predicted and observed probabilities. Decision curve analysis also suggested this model would be clinically useful.

Conclusion
We developed and validated a nomogram which incorporates multiple clinically relevant variables to better identify HSIL + cases during colposcopic examination. This model may help clinicians determining next steps and in particular, around the need to refer patients for colposcopy-guided biopsies.
Primary lymphoma of the lumbar vertebrae: a case report and review of the literature
Authors: Safaei Saeid , Azimi Parisa , Yazdanian Taravat , Molanaei Saadat 
Published: February 2023

Abstract
Background
Primary lymphoma of the spinal vertebrae (PLSV) is an exceedingly rare disease with an unclear optimal treatment plan. We analyzed the clinical features of PLSV in the patient to strengthen our understanding of the disease and to review the literature.

Case presentation
A 65-year-old Persian man was admitted to our hospital with severe low back pain. The patient underwent radiological examinations including computed tomography (CT) scan, magnetic resonance imaging (MRI), and single-photon emission computed tomography (SPECT). These examinations revealed a lesion in the L3 vertebra. Histological analysis showed a high-grade lymphoma. The patient underwent an L3 corpectomy with expandable cage placement, followed by an L2–L4 lateral screw placement with rod fixation. Also, facetectomy, laminectomy, and total spondylectomy were performed. Pedicle screws were inserted from L1 to L5. Titanium mesh was placed on the post-laminectomy defect. The treatment continued with local radiotherapy and chemotherapy. Post-treatment, the patient showed no new neurological deficit, and in the final follow-up, the patient had achieved a good recovery.

Conclusion
To our knowledge, no prior published literature has revealed a primary lymphoma of the lumbar vertebrae. Here, we report this case of PLSV for the first time and provide a brief review of the literature.
Novel Plastic Hinge Element for Seismic Performance Assessment of RC Bridge Columns with Lap Splices
Authors: Kim Tae-Hoon , Eum Ki-Young , Shin Hyun Mock 
Published: February 2023

AbstractThis paper presents a nonlinear analysis procedure for evaluating the seismic performance of reinforced concrete (RC) bridge columns with lap splices using a novel plastic hinge element considering shear deformation. To accurately assess the inelastic behavior of RC bridge columns, reliable three-dimensional (3D) constitutive models are required. However, developing a 3D nonlinear material model is difficult and computationally intensive. In this study, to address these issues, a new plastic hinge element considering shear deformation for RC bridge columns is developed. The new plastic hinge element is based on the Timoshenko beam theory and utilizes two-noded zero length element with six degrees of freedom. The finite element model was implemented in a computer program named Reinforced Concrete Analysis in Higher Evaluation System Technology (RCAHEST) developed by the authors. The developed plastic hinge element for seismic performance assessment of RC bridge columns with lap splices was validated through comparison of the numerical and experimental results.
Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells
Authors: Manchanda Yusman , Bitsi Stavroula , Chen Shiqian , Broichhagen Johannes , Bernardino de la Serna Jorge , Jones Ben , Tomas Alejandra 
Published: February 2023

AbstractThe incretin receptors, glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR), are prime therapeutic targets for the treatment of type 2 diabetes (T2D) and obesity. They are expressed in pancreatic beta cells where they potentiate insulin release in response to food intake. Despite GIP being the main incretin in healthy individuals, GLP-1R has been favored as a therapeutic target due to blunted GIPR responses in T2D patients and conflicting effects of GIPR agonists and antagonists in improving glucose tolerance and preventing weight gain. There is, however, a recently renewed interest in GIPR biology, following the realization that GIPR responses can be restored after an initial period of blood glucose normalization and the recent development of dual GLP-1R/GIPR agonists with superior capacity for controlling blood glucose levels and weight. The importance of GLP-1R trafficking and subcellular signaling in the control of receptor outputs is well established, but little is known about the pattern of spatiotemporal signaling from the GIPR in beta cells. Here, we have directly compared surface expression, trafficking, and signaling characteristics of both incretin receptors in pancreatic beta cells to identify potential differences that might underlie distinct pharmacological responses associated with each receptor. Our results indicate increased cell surface levels, internalization, degradation, and endosomal vs plasma membrane activity for the GLP-1R, while the GIPR is instead associated with increased plasma membrane recycling, reduced desensitization, and enhanced downstream signal amplification. These differences might have potential implications for the capacity of each incretin receptor to control beta cell function.
Osmotic concentration of urine in the dynamics of the development of alloxan-induced experimental diabetes
Authors: Olenovych Olha , Zukow Walery 
Published: February 2023

In order to clarify the peculiarities of the osmotic concentration of urine in the dynamics of the development of alloxan-induced experimental diabetes mellitus (DDM), studies were conducted on 54 sexually mature non-linear male white rats, in which DDM was simulated by a single intraperitoneal injection of alloxan solution (Alloxan monohydrate, "Acros Organics", Belgium) at a dose of 160 mg/kg of body weight after a previous 12-hour food deprivation with preserved access to water. 10, 25, and 45 days after the introduction of the diabetogenic substance, 24 alloxan-diabetic rats, as well as 30 control (intact) animals, were loading with tap water in a volume of 5% of body weight, urine was collected for 2 hours, euthanasia was performed by decapitation under light ether anesthesia. In blood samples, the level of glucose and creatinine was determined, in urine samples, after evaluating the water-induced 2-hour diuresis (in ml/100 g of body weight in 2 hours), the concentration of creatinine was determined, the clearance of endogenous creatinine, the clearance of osmotically free water, as well as relative (tubular) reabsorption of water, determined the content of glucose, urea, its excretion, including per 100 μl of glomerular filtrate, as well as urine osmolarity.
The results of the study allow us to state that as the duration of experimental diabetes is prolonged, the pathogenetic significance of hyperfiltration, which determines the speed of fluid movement along the tubule and the intensity of its absorption, weakens in relation to the processes of osmotic concentration of urine, yielding to other factors, such as the osmolarity of the medulla of the kidneys, as well as the presence of substances in the liquid of the distal segment and collecting tubes, the reabsorption of which can change their concentration in the collecting tubes as the urine progresses. In diabetes, in addition to glucose, such substances include urea. Attempts to analyze the renal excretion of urea revealed that changes in its urinary concentration are definitely correlated with the dynamics of changes in urine osmolality. Moreover, it can be assumed that urea transport disorders in the diabetic kidney occur earlier than the ability to excrete osmotically active substances in general. A joint study of the processes of renal transport of urea and urine osmolarity can serve as an early verifier of tubulointerstitial damage. Nevertheless, to increase the reliability of the interpretation of the features of the osmotic concentration of urine in diabetes, we consider it necessary to study the nature of the renal transport of electrolytes (sodium, potassium, calcium, and ammonium).
Wilson’s disease - a current approach to diagnostics and treatment. A literature review
Authors: Licak Gabriela , Bętkowska Paulina , Olko Paweł , Żuchnik Magda , Rybkowska Agnieszka , Tomkiewicz Julia , Radulski Jakub , Sałata Piotr , Szczuraszek Paulina , Szczuraszek Hugo 
Published: February 2023

Introduction and purpose
Wilson’s disease is a rare autosomal recessive genetic disorder of copper metabolism. Its global genetic prevalence is estimated at around 1:30 000. However, in the case of many patients, it takes a long time to make a diagnosis, which delays introducing the right treatment.
This review aims to gather current knowledge about clinical manifestations, diagnosis, and treatment of Wilson’s disease.
Material and methods
This review was based on available data collected in the PubMed database, using the following keywords: „Wilson’s disease”, „Wilson’s disease treatment”, „Wilson’s disease Pathogenesis”, and “Wilson’s disease Diagnosis”.
ConclusionsThe diagnosis of Wilson’s disease is often delayed due to the wide spectrum of clinical manifestations. Screening of family members of people affected with Wilson’s disease can speed up the diagnosis in yet asymptomatic patients.Raising awareness about Wilson’s disease and diagnosing patients before the onset of serious symptoms may bring earlier diagnosis and improvement in the patient’s quality of life.
Hypnotic suggestion for the treatment of tinnitus
Authors: Suvorkina Alisa , Suvorkin Oleksandr 
Published: February 2023

Aim of study. Considering the high spreading of tinnitus in population, the purpose of our research was to study the possibility and expediency of using hypnosuggestive therapy in treatment of tinnitus.
Material and methods. The study included 55 people with tinnitus complaints. We divided three groups of patients depending on the severity of the manifestations, audiometry results, Tinnitus Handicap Inventory (THI) score according to this scale of severity, results of GAD-7 test and the PHQ-9 (Patient Health Questionnaire -9). Results. In the first group of patients, according to the tinnitus severity scale the score was up to 19 points and was considered as insignificant and mild. The score of the GAD-7 questionnaire was less than 8 points, PHQ-9 - up to 5 points. In the second group the severity of tinnitus was moderate and severe and counted more than 38 points. The GAD-7 questionnaire score was less than 8 points, PHQ-9 - up to 5 points. In the third group, 12 people complained of chronic tinnitus, sleep disturbances, nervousness, and reduced work capacity. The score of tinnitus severity in patients of this group was more than 58 points and was assessed as severe and catastrophic. According to the results of the GAD-7 and PHQ-9 questionnaires, all 12 people were diagnosed with anxiety disorders and depression, two parients even had suicidal thoughts. In the third group of patients with +++ hypnotability, after ten sessions of individual hypno-suggestive therapy, it was possible to reduce the severity of tinnitus to the third moderate degree in 7 people. 4 patients reported about complete regress of tinnitus.
Conclusions. Tinnitus is a common problem and can negatively affect work, family and social life. It requires the individual approach and involvement of specialists of various profiles in the diagnostic process. The diagnostic algorithm for patients with tinnitus should include questionnaires to estimate the psychosomatic profile. The use of hypno-suggestive therapy can significantly reduce the severity of tinnitus and improve the quality of lives of patients.
Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation
Authors: Schroeter Christina B. , Nelke Christopher , Schewe Marcus , Spohler Lucas , Herrmann Alexander M. , Müntefering Thomas , Huntemann Niklas , Kuzikov Maria , Gribbon Philip , Albrecht Sarah , Bock Stefanie , Hundehege Petra , Neelsen Lea Christine , Baukrowitz Thomas , Seebohm Guiscard , Wünsch Bernhard , Bittner Stefan , Ruck Tobias , Budde Thomas , Meuth Sven G. 
Published: February 2023

Abstract
Modulation of two-pore domain potassium (K2P) channels has emerged as a novel field of therapeutic strategies as they may regulate immune cell activation and metabolism, inflammatory signals, or barrier integrity. One of these ion channels is the TWIK-related potassium channel 1 (TREK1). In the current study, we report the identification and validation of new TREK1 activators. Firstly, we used a modified potassium ion channel assay to perform high-throughput-screening of new TREK1 activators. Dose-response studies helped to identify compounds with a high separation between effectiveness and toxicity. Inside-out patch-clamp measurements of Xenopus laevis oocytes expressing TREK1 were used for further validation of these activators regarding specificity and activity. These approaches yielded three substances, E1, B3 and A2 that robustly activate TREK1. Functionally, we demonstrated that these compounds reduce levels of adhesion molecules on primary human brain and muscle endothelial cells without affecting cell viability. Finally, we studied compound A2 via voltage-clamp recordings as this activator displayed the strongest effect on adhesion molecules. Interestingly, A2 lacked TREK1 activation in the tested neuronal cell type. Taken together, this study provides data on novel TREK1 activators that might be employed to pharmacologically modulate TREK1 activity.