bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bundled Care to Reduce Sepsis Mortality: The Improving Pediatric Sepsis Outcomes (IPSO) Collaborative
Authors: Paul Raina , Niedner Matthew , Riggs Ruth , Richardson Troy , DeSouza Heidi Gruhler , Auletta Jeffery J. , Balamuth Frances , Campbell Deborah , Depinet Holly , Hueschen Leslie , Huskins W. Charles , Kandil Sarah B. , Larsen Gitte , Mack Elizabeth H. , Priebe Gregory P. , Rutman Lori E. , Schafer Melissa , Scott Halden , Silver Pete , Stalets Erika L. , Wathen Beth A. , Macias Charles G. , Brilli Richard J. ,   for the IPSO COLLABORATIVE INVESTIGATORS
Published: July 2023

OBJECTIVES
We sought to improve utilization of a sepsis care bundle and decrease 3- and 30- day sepsis-attributable mortality, as well as determine which care elements of a sepsis bundle are associated with improved outcomes.

METHODS
Children’s Hospital Association formed a QI collaborative to Improve Pediatric Sepsis Outcomes (IPSO) (January 2017–March 2020 analyzed here). IPSO Suspected Sepsis (ISS) patients were those without organ dysfunction where the provider “intended to treat” sepsis. IPSO Critical Sepsis (ICS) patients approximated those with septic shock. Process (bundle adherence), outcome (mortality), and balancing measures were quantified over time using statistical process control. An original bundle (recognition method, fluid bolus &lt; 20 min, antibiotics &lt; 60 min) was retrospectively compared with varying bundle time-points, including a modified evidence-based care bundle, (recognition method, fluid bolus &lt; 60 min, antibiotics &lt; 180 min). We compared outcomes using Pearson χ-square and Kruskal Wallis tests and adjusted analysis.

RESULTS
Reported are 24 518 ISS and 12 821 ICS cases from 40 children’s hospitals (January 2017–March 2020). Modified bundle compliance demonstrated special cause variation (40.1% to 45.8% in ISS; 52.3% to 57.4% in ICS). The ISS cohort’s 30-day, sepsis-attributable mortality dropped from 1.4% to 0.9%, a 35.7% relative reduction over time (P &lt; .001). In the ICS cohort, compliance with the original bundle was not associated with a decrease in 30-day sepsis-attributable mortality, whereas compliance with the modified bundle decreased mortality from 4.75% to 2.4% (P &lt; .01).

CONCLUSIONS
Timely treatment of pediatric sepsis is associated with reduced mortality. A time-liberalized care bundle was associated with greater mortality reductions.
RELAÇÃO ENTRE USO DE SUPLEMENTOS NUTRICIONAIS E COMPOSIÇÃO CORPORAL EM PRATICANTES DE MUSCULAÇÃO
Authors: Martins Jamir Iuri Santos , Leite Luciano Bernardes , Cabral Thalita Azevedo , Moura Anselmo Gomes de , Lavorato Victor Neiva 
Published: July 2023

O presente estudo teve como objetivo identificar o perfil do consumidor de suplementos alimentares em uma academia de musculação na cidade de Ubá – MG. Para isso, foram avaliados homens praticantes de musculação. Foi realizada a avaliação da composição corporal através do Índice de Massa Corporal (IMC). Além dessa avaliação, aplicou-se um questionário semiestruturado contendo 12 perguntas objetivas e discursivas, referentes ao perfil dos usuários de suplementos nutricionais. A maior parte dos participantes tinha ensino médio ou superior, fazia uso de whey protein e tinha como principal objetivo o ganho de massa muscular. Além disso, a maioria deles tinha um tempo de prática superior a 1 ano, praticava de 3 a 6 vezes por semana e fazia uso de suplementos pot recomendação dos profissionais de Educação Física. Além disso, os praticantes faziam uso de suplementos, em sua maioria, 4 a 6 vezes na semana ou diariamente. Conclui-se que há necessidade de melhor orientação quanto ao seu uso, a fim de que não ocorra um consumo excessivo ou errôneo.
TENDÊNCIAS DE COMPORTAMENTO SEDENTÁRIO ENTRE ESTUDANTES DO SUL DO BRASIL
Authors: Brito Lilian Messias Sampaio , Moser Deise Cristiane , Tadiotto Maiara Cristina , Menezes-Junior Francisco José de , Titski Ana Cláudia Kapp , Cieslak Fabrício , Corazza Patricia Ribeiro Paes , Mota Jorge , Mascarenhas Luis Paulo Gomes , Leite Neiva 
Published: July 2023

Introduction: Sedentary behavior has been a matter of concern for researchers around the world, especially in Brazil. Objective: This study compared the moderate–vigorous physical activity and sedentary behavior between the years of two surveys (2008 and 2017), relating these behaviors to waist circumference. Methods: Cross sectional study, included 1783 students, both sexes, aged 10 to 17 years were considered: 2008 (n = 977) and 2017 (n = 806). The studies were carried out in public schools in the municipality of southern Brazil. The level of physical activity was assessed through an energy expenditure questionnaire. The waist circumference was considered high ≥75th percentile for age and sex. The students were grouped according to the levels of moderate–vigorous physical activity. Sitting time was used as a proxy of sedentary behavior. Results: The proportion of active boys in 2008 (62.2%) was higher than in 2017 (34.1%; p <0.001) while the frequency of abdominal obesity was higher in 2017 (boys 36.3%, girls 25.5%) than in 2008 (15.7% and 10.5%; p <0.001, respectively). In 2017, there was a 2.8 times increased prevalence risk of increased WC compared to 2008(p <0.001), which was directly related to 16.5 times increase in the risk of elevated sedentary behavior (p <0.001) and two times increase who practice moderate–vigorous physical activity <60min/day (p <0.001). Conclusion: The risk of abdominal obesity increased during the last decade in both sexes, which appears to be mainly due to the sedentary behavior, in addition to the lower level of moderate–vigorous physical activity in boys.
<i>In vivo</i> models in cancer research
Authors: Bokova U. A. , Tretyakova M. S. , Schegoleva A. A. , Denisov E. V. 
Published: July 2023

Cancers are one of the leading causes of mortality in the world. Cellular and physiological mechanisms of cancer development remain not well defined. In vivo models are an attractive approach for understanding of cancer origin and progression. This review presents current state of experimental in vivo systems including syngeneic models, patient-derived xenografts (PDX), cell line-derived xenografts (CDX) and various animals – humanized and genetically engineered models (GEM). These models provide opportunities for developing patients’ avatars, lifetime visualization of tumor migration and invasion at the organism level, and the evaluation of new therapeutic methods aimed at primary tumors, metastases, and cancer prevention. We also discuss the problems of choosing the optimal model and potential solutions for their overcoming.
The specifics of CpG islets methylation of some genes of peripheral blood T-lymphocytes in breast cancer patients before and after treatment
Authors: Goncharova T. G. , Omarbayeva N. A. , Kaidarova D. R. , Orazgaliyeva M. G. , Malysheva L. A. 
Published: July 2023

Introduction. The growth of primary breast tumor morbidity in the last ten years and increased number of patients with disseminated breast cancer in the Republic of Kazakhstan require the search for methods of early diagnosis of malignant tumors. Determination of breast cancer markers in epigenetic studies allows to use them as diagnostic signs of the presence of malignant tumor and as predictors of treatment effectiveness in patients with this pathology.Aim. To perform a search for therapeutic and prognostic breast cancer markers.Materials and methods. The study included samples of biological material (peripheral blood) of 50 deemed healthy individuals and 103 patients with locally advanced and disseminated breast cancer receiving special therapy. The following methods were used: blood collection, DNA extraction, creation of DNA methylation profiles, sequencing, statistical data analysis.Results. The results of search for epigenetic mutations in peripheral blood of patients with breast cancer showed their role as specific diagnostic, therapeutic and prognostic markers with specificity 0.91 % and sensitivity 0.94 %. The hypothesis on therapeutic significance of identified earlier diagnostic markers in patients with breast cancer, namely hypermethylation of CpG islands associated with genes JAM3, C17orf64, MSC, C7orf51 and CpG island associated with intragene part of chromosome 5 (chr5: 77,208,034–77,329,434) was tested and confirmed.Conclusion. A correlation between DNA methylation characteristics and disease progression during treatment was shown. The study results can be used in clinical practice: epigenetic markers, such as methylation in the CpG islets associated with the JAM3, C17orf64, MSC, C7orf51 genes, and in the CpG islet associated with the intragenic site of chromosome 5 (chr5: 77,208,034–77,329,434) can be used as prognostic markers and therapeutic predictors of breast cancer.
Вклад Владимира Александровича Пономаренко — авиационного врача и психолога в развитие отечественной военной авиационной инженерной психологии (к 90-летию ученого)
Authors: Олейник Юрий Николаевич , Звоников Вячеслав Михайлович , Коренкова Наталья Евгеньевна 
Published: July 2023

<p>В статье на материалах работы круглого стола «Владимир Александрович Пономаренко: авиационный врач и психолог (к 90-летию ученого)», проведенного в Московском гуманитарном университете, представлен вклад академика РАО, доктора психологических наук, профессора, генерал-майора медицинской службы В. А. Пономаренко в развитие российской военной авиационной инженерной психологии. </p>
Методология социокультурного познания в условиях общественных изменений
Authors: Карпухин Олег Иванович , Комиссаров Сергей Николаевич 
Published: July 2023

<p>Очевидное наступление новой эпохи всемирной истории после экспансии Запада, направленной на уничтожение России как цивилизации, предполагает пересмотр всего арсенала методов научного познания реально происходящего в геополитической, социально-экономической и социокультурной сферах. Ныне речь идет о переломном характере самой логики человеческой истории, которая сложилась за последние века и в противоречивой, во многом бесчеловечной, реальности которой устойчиво прокладывал дорогу вектор очеловечивания мира и самого человека, составляющий сущность культуры. Сегодня на Западе идет разрушение этого вектора и его основополагающих религиозно-идеологических и духовно-культурных несущих конструкций. Этот антикультурный сдвиг западной цивилизации направлен на озверение человека массы, низложение его до уровня инстинктов «братьев наших меньших» — ради того, чтобы ополовинить человечество и обеспечить беспрекословное подчинение оставшихся интересам верхушки мировой олигархии. Способом достижения этих вполне прозаических интересов стало низложение Бога как идеала человека и ликвидация гуманистической культурной традиции, выработанной человечеством в борьбе за выживание человека как общественного существа. Условием успеха такой стратегии стало уничтожение Российской цивилизации и культуры, которые генетически связаны друг с другом и которые оказались оплотом гуманистической традиции человечества. Недаром попытка физического уничтожения Российского государства, истребления его народов сочетается в новом крестовом походе Запада с искоренением прошлого великой мировой державы, с политикой «культуры отмены», которую В. В. Путин назвал «отменой культуры».</p>
Традиционные ценности: что это означает для России и для западного мира
Authors: Костина Анна Владимировна 
Published: July 2023

<p>В настоящее время, когда формируются контуры нового миропорядка, а мир переходит от однополярности к реальной многополярности, становится очевидным следующее. Причиной межцивилизационных разломов, которые сегодня существенно углубились, является принципиальное различие ценностных систем, определяющих стратегии каждого из субъектов глобальной геополитики. А если это так, то становится очевидным и другое — именно ценности выступают в качестве основной цели современных гибридных и консциентальных войн, и победа в таких войнах соотносится с возможностью защитить и отстоять свои метафизические ценности, свой образ будущего. Традиционные ценности для России и стран с многовековой историей имеют большую значимость, гораздо бóльшую, чем для таких стран, как США, чья история — это история белых переселенцев, не включающая представления как коренного населения Америки, так и перемещенных в эту страну афроамериканцев. Исключение ценностей этих древних народов является характерным для США, провозглашающих в качестве первоочередных императивов «защиту ЛГБТ-сообществ». Между тем в рамках России все 190 народов и народностей сохраняют связь со своей историей и потому особым образом относятся к семье и роду, что органично сочетается с инновационностью, технологичностью и устремленностью в будущее.</p>
Sliding inguinal hernia: a technical challenge
Authors: Vagholkar Ketan , Purandare Tanay 
Published: July 2023

Sliding inguinal hernia continues to be the most challenging hernia to treat. Both diagnosis and treatment pose a dilemma to the attending surgeon. Understanding the pathological anatomy of the sliding inguinal hernia is essential for optimal choice of surgical procedure without causing damage to the involved viscera. A case of sliding inguinal hernia is presented to highlight the diagnostic and technical challenges for repair of sliding hernia. Majority of sliding hernias are diagnosed at the time of surgery. Sigmoid colon is a commonest content in a left sided sliding hernia. Bevan’s technique is best suited to deal with the sac followed by Lichtenstein tension-free mesh repair.
Antibody titre in infants of covid-19 infected mothers
Authors: Sharma Shivani , Meena Pushkar Lal , Suman Rameshwar Lal , Ninama Jaya 
Published: July 2023

COVID‐19 is caused by SARS‐CoV‐2 and spreads from person‐to‐person. Pregnant women continued to be vulnerable to COVID‐19. Infant protection from covid-19 infection is primarily dependent on neonatal innate immune responses and maternally derived, transplacentally acquired antibodies. Our aim was to study trans placental passage of anti-SARS-CoV-2 antibody and the magnitude of natural passive immunity in infants born to mothers with covid 19. Prospective observational study was conducted at Balchikitsalay of MBGH, RNT medical college, Udaipur, Rajasthan from June 2021 to December 2022. Mothers with history of covid-19 positive in past at time of delivery in our hospital[MBGH] and all infants [0 days to 12 months] delivered from covid positive mothers who fulfill inclusion and exclusion criteria were enrolled in study. Measurement of SARS Cov2 antibody titre (serum IgG) in mothers and infants at our central lab where this sample was analysed by electrochemiluminescence. Total 100 covid-19 positive mothers and their infants who fulfill inclusion and exclusion criteria were enrolled in study. Out of 100 infants, 59% were males and 41% were females. Out of 100 infants, 12 (12%) were found in age group of &#60;=3 months, followed by 32 (32%) in 4-6 months age group, 32 (32%) in 7-9 months and 24 (24%) in 10 -12 months age group. In our study 100 infants had different antibody titre level at different age. In Age group &#60;= 3 months had maximum mean value of Antibody titre 135 AU/ml , followed by 26.5 AU/ml in Age group 4-6months ,then 2.5 AU/ml in age group 7-9 months, and 0.5 AU/ml in age group 10-12 months. Antibody titre value sharply fall after birth and antibody titre remain almost one tenth of birth, after age of 3 month. After 6 month of age, it fall below protective level (10 Au/ml). In our study protective value of antibody titre remain till 6th month of age, after that antibody titre decline below protective value. So we recommended that vaccination against covid-19 should be started after 6th month of life like other influenza virus
A rare metachronous presentation of periductal stromal sarcoma in a case of recurrent rhabdomyosarcoma – Case report
Authors: Thangaraja Anusha , B N Tejaswini , Ramaswamy Veena , Uthaiah Sowmya B 
Published: July 2023

Periductal stromal sarcoma (PSS) is a an extremely rare low-grade malignant neoplasm arising from breast periductal stroma. It usually occurs in peri and post-menopausal women. Herein, we report a rare case of a 14 year girl, known case of recurrent Rhabdomyosarcoma (RMS) presenting with periductal stromal sarcoma of breast. To the best of our knowledge, this is a first of its kind to be reported in literature. A 14year girl, known case of Recurrent Pleomorphic Rhabdomyosarcoma of retroperitoneum, presented with an abdominal mass and lump in right breast after 10 years. On chemotherapy, abdominal mass regressed and breast lump progressed in size. On further evaluation by histopathological examination and immunohistochemistry, the breast lump turned out to be a periductal stromal sarcoma. Periductal stromal tumors have histological similarities to phyllodes tumors, with the biphasic presence of hypercellular and variably atypical, mitotically active stroma hugging benign epithelium. There are very few case reports on periductal stromal tumors and thus a rare entity. PSS as a metachronous presentation with recurrent RMS is even more rare with the prevalence of multiple soft tissue sarcomas being 0.08%. A clinically suspected metastatic lesion, if accessible for biopsy, warrants a meticulous histopathological examination to ascertain the cell of origin. The therapeutic strategy and prognosis of PSS is unclear, thus a longer follow up is imperative to determine its prognosis and clinical outcome. 2 case reported so far in younger individuals. 1st case of PSS in a Recurrent RMS.
ДОСЛІДЖЕННЯ ВПЛИВУ ГАЗО-ВОДНЕВОЇ СУМІШІ НА ГАЗОТЕРМОДИНАМІЧНІ ПАРАМЕТРИ РОБОТИ ГАЗОПЕРЕКАЧУВАЛЬНОГО АГРЕГАТУ КОМПРЕСОРНОЇ СТАНЦІЇ
Authors: Андріїшин Михайло , Капітанчук Костянтин , Андріїшин Назар 
Published: July 2023

Розглянуто можливості реалізації вимог водневої стратегії ЄС (EU Hydrogen Strategy), яка передбачає широке використання водню як енергоносія для тих галузей, які не можна електрифікувати, і має за мету довести викиди вуглекислого газу промисловими об’єктами до нуля. Важливим елементом стратегії є розвиток проектів водневої енергетики в рамках підготовки до програми H2Ready, тобто впровадження комплексного підходу щодо можливості транспортування в газотранспортних та газопровідних мережах сумішей природного газу з воднем із вмістом останнього до 20%. Проведено розрахунки режимів роботи ГПА компресорної станції для різної концентрації водню газо-водневої суміші за двома незалежними методиками, що дозволило оцінити достовірність отриманих результатів та зробити відповідні висновки щодо можливості використання наявного обладнання компресорної станції для транспорту газо-водневої суміші магістральним газопроводом. Доведено, що збільшення концентрації водню в газо-водневій суміші призводить до зменшення її енергетичної цінності, але за рахунок зменшення відносної по повітрю густини суміші число Воббе практично не змінюється, тому газо-воднева суміш може бути замінником природного газу.
Показано, що збільшення концентрації водню в газо-водневій суміші при її транспортуванні магістральним трубопроводом призводить до збільшення частоти обертання ротора нагнітача, що призводить до необхідності збільшення потужності приводу ГПА компресорної станції,. Отже, є необхідним проведення реконструкції компресорної станції, а саме заміна приводу з більшою потужністю або зміни конструкції проточної частини нагнітача. Зроблено висновок, що використання наявної інфраструктури ГТС України для транспортування газо-водневої суміші можливо при концентраціях водню до 4%.
Study of Air Polluted by Microparticles in the City of Apatity, Murmansk Region
Authors: Goryachev A.A. , Amosov P.V. , Kompachenko А.A. , Mingaleva T.A. , Duplishcheva A.V. , Konina O.T. , Makarov D.V. 
Published: July 2023

Surface layers of apatite-nepheline ores mill tailings were analyzed. During the snowless period in2022, the dynamics of PM2.5 and PM10 dust concentrations in the atmosphere air of Apatity, Murmansk Region, was studied. Excess of MAC of sparingly solubles were detected. Mineralogical analysis of tailings and dust samples were carried out, the presence of nepheline and sodalite was detected, which confirms the involvement of tailing dumps of apatite-nepheline processing plants in air pollution. It was concluded that, in addition to the tailing dump, transport and other industrial sites have a significant impact on the atmosphere air, since airborne dust samples contain small particles of oxidized iron, plastic, glass, and metal scale. The role of green areas in buffer zones and within the boundaries of urban development was emphasized.
On the issue of the development of religious tourism in the Republic of Dagestan
Authors: Abasova A. A. 
Published: July 2023

Aim. The article deals with the development of religious tourism in the Republic of Dagestan as excursions, educational and religious studies and pilgrimage tours. Discussion. The recreational potential of the republic includes numerous places of worship, monuments of spiritual culture and cultural and historical complexes, favourable natural and climatic conditions, the warm Caspian Sea and sandy beaches and unique natural objects, such as the Sulak Canyon, the Sary‐Kum dune, the Saltinsky underground waterfall, the Samur forest, the Tobotsky waterfall, majestic mountains, which have attracted a large number of guests to Dagestan in recent years. During 2022, more than one and a half million people visited the republic, while the population in the republic itself is three million. In view of the fact that paganism, Zoroastrianism, Judaism and Christianity were practiced on the territory of modern Dagestan before the spread of Islam, cult objects associated with these religions have been preserved. Of course, the largest group of places of worship is associated with Islam. Conclusion. The presence in Dagestan of shrines associated not only with Islam, but also with Christianity, makes it possible to develop religious tourism in the republic not only in the form of excursions and educational and religious studies, but also pilgrimage tours for believing citizens of the country, which will undoubtedly contribute to the education of religious tolerance and mutual understanding of representatives of different religions.
The assessment of quality of groundwater used for drinking by the population of the Republic of Dagestan, Russia
Authors: Abdulmutalimova T. O. , Ramazanov O. M. , Alhasov A. B. , Gazaliev I. M. 
Published: July 2023

Aim. Features of the geological structure of the region determine the diversity of the chemical composition of groundwater, represented by springs in the mountainous part of the Republic of Dagestan and artesian waters in the plains. The content of some contaminants in drinking water can affect public health and have negative consequences. The purpose of the work is to conduct a comparative analysis of the regional characteristics of groundwater and substantiate their compliance with hygienic standards for the quality of drinking water. Materials and methods. More than 500 samples of drinking water were taken on the territory of the republic and analysed in the analytical laboratories of the Institute for Problems of Geothermy and Renewable Energy, a branch of the Joint Institute for High Temperatures of the Russian Academy of Sciences and the Institute of Geology of the Dagestan Federal Research Center of the Russian Academy of Sciences. Assessment of carcinogenic risks to public health was carried out in accordance with Guideline 2.1.10.1920‐04.Results. In some mountainous settlements increased values of hardness (up to 14) were revealed, as well as iodide deficiency almost everywhere. In the underground waters of lowland settlements, an increased content of phenols, cadmium and arsenic was revealed.Conclusion. The use of groundwater by the population for drinking purposes in mountainous areas is possible with the preliminary implementation of appropriate water softening measures and preventive measures among the population related to the replenishment of iodine deficiency. The underground waters of the lowland areas do not meet the hygienic requirements for content of arsenic, cadmium and phenols and the carcinogenic risks for the population are at a level unacceptable for the population.