bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respiratory Viral Infections in Recipients of Cellular Therapies: A Review of Incidence, Outcomes, Treatment, and Prevention
Authors: Wilson Dib Rita , Ariza-Heredia Ella , Spallone Amy , Chemaly Roy F 
Published: March 2023

AbstractRespiratory viral infections (RVIs) are of major clinical importance in immunocompromised patients and represent a substantial cause of morbidity and mortality in patients with hematologic malignancies and those who have undergone hematopoietic cell transplantation. Similarly, patients receiving immunotherapy with CD19-targeted chimeric antigen receptor–modified T cells, natural killer cells, and genetically modified T-cell receptors are susceptible to RVIs and progression to lower respiratory tract infections. In adoptive cellular therapy recipients, this enhanced susceptibility to RVIs results from previous chemotherapy regimens such as lymphocyte-depleting chemotherapy conditioning regimens, underlying B-cell malignancies, immune-related toxicities, and secondary prolonged, profound hypogammaglobulinemia. The aggregated risk factors for RVIs have both immediate and long-term consequences. This review summarizes the current literature on the pathogenesis, epidemiology, and clinical aspects of RVIs that are unique to recipients of adoptive cellular therapy, the preventive and therapeutic options for common RVIs, and appropriate infection control and preventive strategies.
Song Lyrics and Melodies in the Edward Bunting Collection
Authors: Lavelle Eilís 
Published: March 2023

Abstract
This chapter demonstrates possibilities of how one might attempt to synthesize texts and melodies found in the unpublished manuscript collection of Edward Bunting (1773–1843), focusing on one song in particular: ‘Nelly an Chúil Chraobhaigh’ as notated by two scribes, James Cody and Patrick Lynch, for Bunting. Attempts at combining text and melody are undertaken using melodies notated by James Cody and lyrics found in both Cody and Patrick Lynch’s hands. The difficulties and challenges of the process in matching lyrics to various melodic settings are discussed. In the case of the Bunting collections, these difficulties were compounded by the nature of the notations and the hugely different skills and traditions which Bunting, Lynch, and Cody brought to their work. That some of the songs and song-tunes which were notated in Bunting’s collection, including ‘Nelly an Chúil Chraobhaigh’, are still sung today demonstrates both the possibilities and rewards of revisiting this important archive.
On the Zeeman effect in magnetically arrested disks
Authors: Inoue Yoshiyuki 
Published: March 2023

Abstract
The magnetically arrested disk (MAD) scenario has been argued as the key accretion phase to realize the formation of relativistic jets. However, due to the lack of magnetic field measurements of accreting systems, MAD has not been observationally confirmed yet. Here we propose that a strong magnetic field accompanied by MAD would induce the Zeeman splitting of relativistically broadened Fe Kα fluorescence lines in X-ray binaries and active galactic nuclei, where we consider a two-phase medium in the inner accretion disk, magnetically dominated hot corona, and cold reflector. Such a geometrical configuration is suggested from X-ray observations and recently confirmed by numerical simulations. Although turbulence in accretion flows would broaden the split lines, future X-ray high-energy resolution satellites, XRISM and Athena, would be capable of seeing the Zeeman effect on the Fe lines in X-ray binaries in the case with the MAD configuration. The signature of the Zeeman split lines would provide observational evidence for MAD.
Fast response of vegetation in East Asia to abrupt climatic events during the last deglaciation
Authors: Xu Deke , Lu Houyuan , Chu Guoqiang , Shen Caiming , Sun Qing , Wu Jing , Li Fengjiang , Song Bing , Cui Anning , Li Hao , Wu Naiqin 
Published: March 2023

Abstract
Climate changes had major impacts on the vegetation of East Asia during the last deglaciation. However, the rate and pattern of vegetation succession in response to large-scale climatic events during this interval are controversial. Here, we present well-dated decadal-resolution pollen records from annually laminated Maar Lake Xiaolongwan during the last deglaciation. The vegetation changes were rapid and near-synchronous with millennial-scale climatic events, including Greenland Stadial 2.1a (GS-2.1a), Greenland Interstadial 1 (GI-1), Greenland Stadial 1 (GS-1), and the early Holocene (EH). The vegetation responded in different ways to the different rates of climate change. Vegetation change was gradual [∼1 thousand years (kyr) response time] during the transition between GS-2.1a and GI-1, but it was faster (∼0.4 kyr response time) during the transitions between GI-1, GS-1, and the EH, resulting in different patterns of vegetation succession. Additionally, the amplitude and pattern of vegetation changes resembled those in the records of regional climate change based on long-chain n-alkanes δ13C and stalagmite δ18O, as well as in the mid-latitude Northern Hemisphere temperature record and the Greenland ice core δ18O record. Therefore, the rate and pattern of vegetation succession in the Changbai Mountain of Northeast Asia during the last deglaciation were sensitive to the characteristics of changes in the regional hydrothermal conditions and mid-latitude Northern Hemisphere temperature, which were linked to both high- and low-latitude atmospheric-oceanic dynamics. Overall, our findings reveal a close relationship between ecosystem succession and hydrothermal changes during these millennial-scale climatic events in East Asia during the last deglaciation.
Portfolio use in postgraduate medical education: a systematic scoping review
Authors: Lim Annabelle Jia Sing , Hong Daniel Zhihao , Pisupati Anushka , Ong Yun Ting , Yeo Jocelyn Yi Huang , Chong Eleanor Jia Xin , Koh Yi Zhe , Wang Mingjia , Tan Rei , Koh Kai Kee , Ting Jacquelin Jia Qi , Lam Betrand Kai Yang , Chiam Min , Lee Alexia Sze Inn , Chin Annelissa Mien Chew , Fong Warren , Wijaya Limin , Tan Laura Hui Shuen , Krishna Lalit Kumar Radha 
Published: March 2023

Abstract

Background
Portfolios are increasingly commonplace in postgraduate medical education. However, poor understanding of and variations in their content, quality, and structure have hindered their use across different settings, thus dampening their efficacy.

Methods
This systematic scoping review on portfolios in postgraduate medical education utilized Krishna’s Systematic Evidence Based Approach (SEBA). Braun and Clarke’s thematic analysis and Hsieh and Shannon’s directed content analysis were independently used to evaluate the data.

Results
In total, 12 313 abstracts were obtained, and 76 full-text articles included. Six key themes/categories were identified: (i) portfolio definitions and functions, (ii) platforms, (iii) design, (iv) implementation, (v) use in assessments, and (vi) evaluations of their usage.

Conclusions
Portfolios allow for better appreciation and assessments of knowledge, skills, and attitudes in time-, learner-, and context-specific competencies through the establishment of smaller micro-competencies and micro-credentialling. Organized into three broad stages—development, implementation, and improvement—a six-step framework for optimizing and instituting portfolios in postgraduate medical education is offered.
The Geography of Unemployment
Authors: Bilal Adrien 
Published: March 2023

Abstract
Unemployment rates differ widely across local labor markets. I offer new empirical evidence that high local unemployment emerges because of elevated local job-losing rates. Local employers, rather than local workers or location-specific factors, account for most of the spatial gaps in job stability. I propose a theory in which spatial differences in job loss emerge in equilibrium because of systematic differences between employers across local labor markets. The spatial sorting decisions of employers in turn shape heterogeneity across locations. Labor market frictions induce productive employers to overvalue locating close to each other. The optimal policy incentivizes them to relocate toward areas with high job-losing rates, providing a rationale for commonly used place-based policies. I estimate the model using French administrative data. The estimated model accounts for over three-quarters of the cross-sectional dispersion in unemployment rates and for the respective contributions of job-losing and job-finding rates. Inefficient location choices by employers amplify spatial unemployment differentials fivefold. Both real-world and optimal place-based policies can yield sizable local and aggregate welfare gains.
How to self-examine for tender and swollen joints: co-producing a training video for people with rheumatoid arthritis
Authors: Sharp Charlotte A , Staniland Karen , Gandrup Julie , Cornell Trish , Dixon William G 
Published: March 2023

AbstractObjectiveThis paper describes the co-production of a training video to support people with RA to self-examine for tender and swollen joints.MethodsThe patient and public involvement and engagement (PPIE) group supporting a remote monitoring study elected to develop a video to train people with RA how to self-examine for tender and swollen joints, because nothing appropriate was publicly available to fulfil their needs. A core team of PPIE group members and clinicians developed the video, with input from conception to dissemination from the PPIE group. The video was posted, open access, on a YouTube website in February 2021, alongside supporting materials. The number of monthly hits was tracked and a survey developed to ascertain feedback.ResultsThe video received 1000 hits in the first week, and &gt;40 000 at 10 months. The top three countries viewing the video were India, the USA and the UK, with a range of ages and gender profile broadly corresponding to those of RA patients. Forty-eight survey responses were received (26 patients and 22 clinicians). Patients reported an improvement in their ability to self-examine after watching this video. Eighty-six per cent of patients and 71% of clinicians would recommend the video. It has been used and disseminated by a number of national organizations within the UK.ConclusionThis co-produced, open-access training video for people with RA, originally intended to support a research study into remote monitoring, has been well received, reflecting an international interest in self-examination.
Changes in sexual activities, function, and satisfaction during the COVID-19 pandemic era: a systematic review and meta-analysis
Authors: Qaderi Kowsar , Yazdkhasti Mansoureh , Zangeneh Sanaz , Behbahani Bahar Morshed , Kalhor Mehri , Shamsabadi Ahmadreza , Jesmani Younes , Norouzi Solmaz , Kajbafvala Mehrnaz , Khodavirdilou Rasa , Rahmani Nahid , Namadian Masoumeh , Ezabadi Sajjad Ghane , Alkatout Ibrahim , Mehraeen Esmaeil , Rasoal Dara 
Published: March 2023

Abstract

Introduction
Little is known about the impact of the coronavirus on sexual behavior, function, and satisfaction.

Aim
The aim of the present study was to systematically review people’s sexual function and behaviors and their changes in sexual activities during the COVID-19 pandemic.

Methods
Comprehensive searches in PubMed, Web of Science, and Scopus were conducted with keywords in accordance with MeSH terms: COVID-19, SARS-CoV-2, coronavirus, sexual health, sexual function, sexual dysfunctions, sexuality, sexual orientation, sexual activities, and premarital sex. Two reviewers independently assessed full-text articles according to predefined criteria: original design, English studies, and investigating either the general population or sexual minorities.

Results
Risk of bias in the studies was assessed by the Newcastle-Ottawa Scale, and data were pooled via random effects meta-analyses. We utilized the standardized mean difference to evaluate the effects of the COVID-19 pandemic on sexual activity, functioning, and satisfaction. We included 19 studies in the analysis and 11 studies in the meta-analysis, with a sample size of 12 350. To investigate sexual activity changes, a sample size of 8838 was entered into the subgroup analysis, which showed a significant decrease in both genders (5821 women, P &lt; .033; 3017 men, P &lt; .008). A subgroup meta-analysis showed that the sexual function of men and women during the COVID-19 pandemic significantly declined (3974 women, P &lt; .001; 1427 men, P &lt; .001). Sexual desire and arousal decreased in both genders, though mainly in women. In investigating sexual satisfaction changes during the COVID-19 pandemic, a meta-analysis with a sample size of 2711 showed a significant decrease (P &lt; .001). The most indicative changes in sexual behaviors during the pandemic were the increase in masturbating and usage of sex toys. Greater COVID-19 knowledge was associated with lower masturbation, oral sex, and vaginal sex. The more protective behaviors were associated with less hugging, kissing, cuddling, genital touching, watching porn with a partner, and vaginal sex.

Conclusion
The COVID-19 pandemic led to increased challenges and changes for individuals’ sexual behaviors. Efforts for preventive strategies should therefore be concentrated between pandemics, while ensuring that there is information available to the population during a pandemic for help in times of psychological distress or crisis.
Switching ubiquitous and muscle‐specific isoforms of mitochondrial respiratory complex IV in skeletal muscle fine‐tunes complex IV activity
Authors: Ye Xianglai , Xie Yaojun , Shi Yu , Wang Bo , Han Xinyu , Zhou Xiaoxuan , Pan Kexin , Wang Maofeng , Fang Hezhi 
Published: March 2023

AbstractRespiratory complex IV (CIV, cytochrome c oxidase) is the terminal enzyme of the mitochondrial electron transport chain. Some CIV subunits have two or more isoforms, which are ubiquitously expressed or are expressed in specific tissues like the lung, muscle, and testis. Among the tissue‐specific CIV isoforms, the muscle‐specific isoforms are expressed in adult cardiac and skeletal muscles. To date, the physiological and biochemical association between the muscle‐specific CIV isoforms and aerobic respiration in muscles remains unclear. In this study, we profiled the CIV organization and expression pattern of muscle‐specific CIV isoforms in different mouse muscle tissues. We found extensive CIV‐containing supramolecular organization in murine musculature at advanced developmental stages, while a switch in the expression from ubiquitous to muscle‐specific isoforms of CIV was also detected. Such a switch was confirmed during the in vitro differentiation of mouse C2C12 myoblasts. Unexpectedly, a CIV expression decrease was observed during C2C12 differentiation, which was probably due to a small increase in the expression of muscle‐specific isoforms coupled with a dramatic decrease in the ubiquitous isoforms. We also found that the enzymatic activity of CIV containing the muscle‐specific isoform COX6A2 was higher than that with COX6A1 in engineered HEK293T cells. Overall, our results indicate that switching the expression from ubiquitous to muscle‐specific CIV isoforms is indispensable for optimized oxidative phosphorylation in mature skeletal muscles. We also note that the in vitro C2C12 differentiation model is not suitable for the study of muscular aerobic respiration due to insufficient expression of muscle‐specific CIV isoforms.
Novel Application of Immunochromatographic Assay for Measurement of Total Tear Immunoglobulin E
Authors: Liu Xuhui , Wang Gaixin , He Jiwu , Xu Yunqiang , Yang Jinbo , Qian Zhuyun , Tao Yong 
Published: March 2023

Purpose:
The aim of this study was to evaluate the efficacy of a new immunochromatographic assay (Aifeice) in the diagnosis of allergic conjunctivitis diseases (ACDs) and to explore the relationship between Aifeice testing results and the severity of ACDs.

Methods:
A multicenter prospective cross-sectional study (390 patients diagnosed with ACDs and 619 healthy controls) was conducted. Patients with ACDs were scored based on clinical symptoms. All participants received the Aifeice test. The positive testing results were further divided into 3 immunoglobulin E (IgE) grades. Statistical analysis was performed to evaluate the indexes associated with the testing results.

Results:
The sensitivity, specificity, positive predictive value, negative predictive value, and total coincidence rate of the Aifeice test were 96.15%, 98.87%, 98.17%, 97.61%, and 97.82%, respectively. The total clinical score was significantly correlated with the IgE grade. The factors that affected the IgE score were conjunctival hyperemia, conjunctival swelling, conjunctival papillae, and Horner–Trantas dots.

Conclusions:
The high sensitivity and specificity of Aifeice in the diagnosis of ACD was confirmed. This new immunochromatographic assay could be used to assess the severity of ACD.
Working Alone and/or in Remote Locations
Authors: Zimmerman Stacy M. , Scott Kenneth A. , Wingate Kaitlin C. , Ramirez-Cardenas Alejandra , Pompei Richard , Hagan-Haynes Kyla , Hill Ryan D. , Wood Eric 
Published: March 2023

Objective
The aim of the study is to explore personal and work factors related to fatal cardiac events among oil and gas extraction (OGE) workers.

Methods
The National Institute for Occupational Safety and Health Fatalities in Oil and Gas Extraction database was reviewed to identify fatal cardiac events among OGE workers from 2014 through 2019. A case series design was used to review case files, provide descriptive statistics, and summarize the findings.

Results
There were 75 fatalities identified, including 55 (73%) with sufficient information for review. Of the 55 workers, 18 (33%) worked alone. Thirty-six fatal cardiac events (66%) were unwitnessed by a coworker. Toxicology findings suggested some possible exposures to hydrogen sulfide or hydrocarbon gases or vapors. Missing data were common.

Conclusions
This study identified the need for cardiovascular disease prevention and treatment, emergency preparedness, lone worker programs, medical screening, and enhanced exposure control in the OGE industry.
Curative Effect Analysis of Endoscopic Submucosal Dissection in Giant Laterally Spreading Rectal Tumors
Authors: Nie Xubiao , Jiang Airui , Wu Xiaoling , Bai Jianying , He Song 
Published: March 2023

Goal:
The objective of this study was to investigate the clinical efficacy of endoscopic submucosal dissection (ESD) in the treatment of giant lateral developing rectal-type tumors (laterally spreading tumors, LSTs).

Background:
There are no specialized studies on the efficacy of ESD in the treatment of LSTs measuring >5 cm in diameter, surgery was often used in the past, but it has the disadvantages of large trauma, many complications, and high cost.

Methods:
The data of 185 patients with rectal LSTs who had undergone ESD in the digestive endoscopy center of our hospital from January 2012 to June 2020 were retrospectively analyzed. Based on the size of the lesions, the patients were divided into 2 groups: diameter ≤5 cm (110 cases) and diameter >5 cm (75 cases), and we summarized and analyzed the en bloc resection rate, curative resection rate, procedure time, muscle injury, bleeding, perforation, postoperative stricture, and recurrence.

Results:
There was no difference in the en bloc resection rate and R0 resection rate between the 2 groups (P=0.531). Moreover, there was no difference in the incidence of delayed perforation, postoperative stenosis, and recurrence, but the incidence of delayed bleeding was significantly higher in the giant LST group than the small LST group (P=0.001). Moreover, for giant rectal LSTs, the growth pattern of the lesion, JNET classification, and the extent of postoperative mucosal defect do not significantly affect the efficacy of ESD. It is worth mentioning that the operation time was longer in the group with a diameter >5 cm, in which perforation was more frequent and the muscle layer was more likely to be injured during ESD (P<0.001). The muscle injury during ESD was mainly related to the diameter of the lesion, the crossing the rectal pouch, and the operation time.

Conclusions:
The use of ESD to treat giant rectal LSTs (>5 cm) is relatively difficult and can easily lead to intraoperative muscle injury, perforation, and late postoperative bleeding. However, if active intervention is performed, patients can still achieve good efficacy and prognosis, which can be applied in hospitals with certain conditions.
Exploring the immunological role and prognostic potential of PPM1M in pan-cancer
Authors: Zeng Rongruo , Wang Lulu , Zhang Yuxu , Yang Ye , Yang Jie , Qin Yan 
Published: March 2023

Background:

PPM1M is a member of the metal-dependent protein phosphatase family, and its role in the immunization process has not been studied in depth. In this study, we investigated the role of PPM1M in pan-cancer.

Methods:
Samples of cancer and normal tissues were obtained from the cancer genome atlas and genotype-tissue expression. Kaplan–Meier survival curves and Cox regression were used to analyze the effect of PPM1M on prognosis. Functional and pathway enrichment analyses were performed using the R package “clusterProfiler” to explore the role of PPM1M. The Sanger Box database was used to analyze the relationship between PPM1M and tumor immune checkpoint, tumor mutational burden, and microsatellite instability. The Tumor Immune Estimation Resource 2 database and CIBERSORT method were used to analyze the relationship between PPM1M and tumor-infiltrating immune cells. Finally, the cBioPortal database was used to analyze the genomic variation in PPM1M.

Results:
Among the variety of tumors, the expression of PPM1M was higher in normal tissues than in cancerous tissues. The expression of PPM1M is closely associated with patient prognosis, tumor immune checkpoint, tumor mutational burden, and microsatellite instability. PPM1M is closely associated with the infiltration of immune cells into the tumor microenvironment. In addition, PPM1M is involved in the regulation of several immune-related pathways.

Conclusion:
In pan-cancer, PPM1M affects patient prognosis and may be a potential immunological biomarker. Furthermore, PPM1M may be a potential therapeutic target in tumor immunology.