bluuebunny/crossref_metadata_2025_split huggingface dataset:
HEalth professionals Responding to MEn for Safety (HERMES): Mixed methods evaluation of a pilot sexual health intervention for gay, bisexual and other men who have sex with men experiencing domestic violence and abuse
Authors: Buller Ana Maria , Ferrari Giulia , Bleile Alexandra , Feder Gene S. , Brzank Petra J. , Bacchus Loraine J. 
Published: January 2025

Background
Domestic violence and abuse (DVA) is a violation of human rights that damages the health and well-being of—gay, bisexual and other men who have sex with men (gbMSM). Sexual health services provide a unique opportunity to assess for DVA and provide support. This study explores the feasibility and acceptability of Healthcare Responding to Men for Safety (HERMES), a pilot intervention aimed to improve the identification and referral of gbMSM experiencing DVA in a London NHS Trust.

Methods
The before and after mixed method evaluation of the intervention included semi-structured interviews with 21 sexual health practitioners, 20 matched pre-post questionnaires, and an audit of 533 patient records to assess identification and referral of gbMSM experiencing DVA.

Results
HERMES increased practitioners’ self-reported preparedness and confidence in enquiring, identifying and responding to gbMSM experiencing DVA. HERMES increased staff awareness of DVA among these patients, which led to higher identification practices in their work. There was a significant increase in the identification and reporting practices of trained staff (0% to 30%), with 6 (5%) DVA cases identified. However, as far as we could determine, none of these patients contacted the support agency.

Conclusions
HERMES proved successful in raising staff awareness, provided tools that increased identification and a referral pathway to an external specialist DVA service for the LGBT community. However, the poor uptake of the referral service indicates a need for further exploration of the help-seeking behaviour of gbMSM experiencing DVA and whether they would prefer to receive support within a sexual health service. Reinforcement training and clinical supervision is needed to sustain positive changes in practice over time and address potential challenges posed by staff turnover. Initial training should be conducted through face-to-face sessions with a combination of in-person and e-learning materials and followed by in-person and online reinforcement activities.
Relationship between mental health and substance abuse on COVID-19 vaccine hesitancy in youth: A mixed methods longitudinal cohort study
Authors: Everest Louis , Henderson Joanna , Ma Clement , Prebeg Matthew , Relihan Jacqueline , Hawke Lisa D. 
Published: January 2025

Background
Mental health and substance use challenges are highly correlated in youth and have been speculated to be associated with COVID-19 vaccine hesitancy. Literature has also suggested that mental health challenges in youth have increased during the COVID-19 pandemic. However, the longitudinal relationship between mental health challenges in youth and COVID-19 vaccine hesitancy is not well established.

Objective
We examined the relationship between mental health, substance use and COVID-19 vaccine hesitancy in youth during the COVID-19 pandemic.

Methods
Youth ages 14 to 29-years participated in a longitudinal survey study. Participants provided sociodemographic, mental health, and substance use data, as well as qualitative and quantitative information on their vaccine perspectives every two months between February 2021 to August 2021, and on February 2022. Generalized estimating equation logistic regression models were used to analyze the effect of mental health and substance use on vaccine hesitancy over time. Qualitative content area analyses were used to identify trends in vaccine attitudes.

Results
Mental health challenges and substance use frequency were associated with vaccine hesitancy, and significantly increased the odds of vaccine hesitancy over time. Additionally, mental health challenges were associated with decreases in vaccine hesitancy (OR: 0.80 (95% CI 0.66, 0.97)) when vaccines first began to emerge, but increases in vaccine hesitancy (OR: 1.72 (95% CI 1.32, 2.26)) one year later. Participants reported perceptions regarding vaccine safety and efficacy were the primary determinants influencing hesitant, uncertain, and acceptant vaccine attitudes. Additionally, changes in vaccine attitudes over time for some participants, were associated with changes in mental health.

Conclusions
Increases in mental health challenges and substance use were associated with increases in COVID-19 vaccine hesitancy in youth over the COVID-19 pandemic. Health policy agencies should be aware of the potential impact of mental health challenges and substance use in youth, when developing vaccine policy and programs.
Digital measurement of ocular microtremor in Parkinson’s disease: Protocol for a pilot study to assess reliability and clinical validation
Authors: Graham Lisa , Vitorio Rodrigo , Walker Richard , Godfrey Alan , Morris Rosie , Stuart Samuel 
Published: January 2025

Ocular microtremor (OMT) is a fixational eye movement that cannot be seen with the naked eye but is always present, even when the eye appears motionless/still. The link between OMT and brain function provides a strong rationale for investigation as there lies potential for its use as a biomarker in populations with neurological impairments. OMT frequency is typically 70-80Hz in healthy adults and research suggests that this will be reduced in those with neurological disease such as Parkinson’s Disease (PD). This study aims to examine OMT in people with PD compared to healthy older adults. This is an exploratory, observational study that will use a novel handheld device–The iTremor ONE, which has been developed to rapidly, non-invasively assess and evaluate OMT frequency. This device uses incident laser technology directed at the sclera. People with PD who meet the inclusion criteria will participate in a home-based assessment involving cognitive, motor (using the UPDRS-III) and OMT measures. With OMT as the primary outcome, assessment with the iTremor is quick, taking just three seconds to obtain a reading. People with PD will be invited into the laboratory to perform extensive cognitive assessments along with an assessment of balance, gait, and turning using wearable sensors. People with PD will be assessed both off, and on, their anti-parkinsonian medication following a 12 hour washout period. We will recruit 30 People with PD, 30 people with suspected PD and 30 age-matched healthy control participants for assessment of OMT. 20 People with PD will complete a test-retest reliability assessment at the same approximate time, exactly one week after their initial visit under the same conditions to explore consistency. This will be the first study of its kind to non-invasively investigate OMT frequency as a marker/monitor for PD with advanced technology that could be used within the clinic, laboratory, or home. Identifying OMT as a PD biomarker could better support clinical assessment, enabling improved provision of care to patients with advanced disease monitoring.
Clinical trial registration: This trial is registered at clinicaltrials.gov (NCT06051877; September 2023).
Opening the digital doorway to sexual healthcare: Recommendations from a behaviour change wheel analysis of barriers and facilitators to seeking online sexual health information and support among underserved populations
Authors: McLeod Julie , Estcourt Claudia S. , MacDonald Jennifer , Gibbs Jo , Woode Owusu Melvina , Mapp Fiona , Gallego Marquez Nuria , McInnes-Dean Amelia , Saunders John M. , Blandford Ann , Flowers Paul 
Published: January 2025

Background
The ability to access and navigate online sexual health information and support is increasingly needed in order to engage with wider sexual healthcare. However, people from underserved populations may struggle to pass though this “digital doorway”. Therefore, using a behavioural science approach, we first aimed to identify barriers and facilitators to i) seeking online sexual health information and ii) seeking online sexual health support. Subsequently, we aimed to generate theory-informed recommendations to improve these access points.

Methods
The PROGRESSPlus framework guided purposive recruitment (15.10.21–18.03.22) of 35 UK participants from diverse backgrounds, including 51% from the most deprived areas and 26% from minoritised ethnic groups. Using semi-structured interviews and thematic analysis, we identified barriers and facilitators to seeking online sexual health information and support. A Behaviour Change Wheel (BCW) analysis then identified recommendations to better meet the needs of underserved populations.

Results
We found diverse barriers and facilitators. Barriers included low awareness of and familiarity with online information and support; perceptions that online information and support were unlikely to meet the needs of underserved populations; overwhelming volume of information sources; lack of personal relevancy; chatbots/automated responses; and response wait times. Facilitators included clarity about credibility and quality; inclusive content; and in-person assistance. Recommendations included: Education and Persuasion e.g., online and offline promotion and endorsement by healthcare professionals and peers; Training and Modelling e.g., accessible training to enhance searching skills and credibility appraisal; and Environmental Restructuring and Enablement e.g., modifications to ensure online information and support are simple and easy to use, including video/audio options for content.

Conclusions
Given that access to many sexual health services is now digital, our analyses produced recommendations pivotal to increasing access to wider sexual healthcare among underserved populations. Implementing these recommendations could reduce inequalities associated with accessing and using online sexual health service.
Inflammatory Bowel Disease, Periconceptional Disease Activity, and Risk of Major Congenital Anomalies: A Nationwide Cohort Study
Authors: Mårild Karl , Söderling Jonas , Stephansson Olof , Axelrad Jordan , Halfvarson Jonas ,   SWIBREG Study Group, Bröms Gabriella , Marsal Jan , Neovius Martin , Pasternak Björn , Olén Ola , Ludvigsson Jonas F. 
Published: January 2025

INTRODUCTION:
It is uncertain whether the risk of major congenital anomalies (mCAs) is increased in children of women with inflammatory bowel disease (IBD).

METHODS:
We aimed to determine the risk of mCAs in a Swedish nationwide cohort of 13,131 singleton live births from 1997 to 2020 to women with IBD and 61,909 matched children to women without IBD from the general population. We additionally examined mCAs according to periconceptional histological inflammation (vs remission: 1,124 and 646 births, respectively) or clinically active IBD (vs quiescent: 3,380 and 6,603 births, respectively). Adjusted risk ratios (aRRs) for overall and organ-specific mCAs were estimated using generalized linear models. These models adjusted for maternal sociodemographics, comorbidities, body mass index, and smoking.

RESULTS:
There were 38.0 (n = 499) mCAs per 1,000 births to women with IBD vs 33.9 (n = 2,101) in matched comparators and a risk difference of 1 extra mCA per 246 births to women with IBD (aRR 1.11; 95% confidence interval [CI] 1.01–1.23). Risks of heart defects and mCAs of the urinary system partly drove estimates. The risk of mCAs was similar in children of women with ulcerative colitis and Crohn's disease. Periconceptional histological inflammation (vs remission) or clinically active (vs quiescent) IBD did not further influence the risk of mCA in the child (aRR 0.87 [95% CI 0.55–1.40] and aRR 1.04 [95% CI 0.85–1.27], respectively).

DISCUSSION:
Children of women with IBD had a heightened susceptibility to mCAs, although absolute and relative risks were lower than previously reported. IBD activity was not linked to mCA risks, but those analyses included relatively few events.
Effects of acetazolamide on intracranial pressure and brain tissue oxygenation on patients with acute brain injury: A pilot physiological study
Authors: Hachlouf Anas , Stella Claudia , Cavalli Irene , Gouvêa Bogossian Elisa , Schuind Sophie , Anderloni Marco , Taccone Fabio Silvio 
Published: January 2025

AbstractThe effect of acetazolamide on regional brain tissue oxygenation in patients with acute brain injury (ABI) is unknown. We studied adult patients with ABI who received acetazolamide as per the treating physician's decision and had ICP and brain oxygen pressure (PbtO2) monitoring. Baseline measurements of ICP, cerebral perfusion pressure (CPP), and PbtO2 were taken before administering acetazolamide; subsequent measurements were recorded every 5 min for a total of 20 min. Mean cerebral blood velocities (FVm) and pulsatility index (PI) were measured using transcranial color‐coded duplex (TCCD) sonography at baseline and after 20 min. Fourteen patients with subarachnoid hemorrhage (n = 6), traumatic brain injury (n = 7), and intracranial hemorrhage (n = 1) were included. Following administration of acetazolamide, ICP showed a significant increase within 20 min (p < 0.001), with no significant change in CPP (p = 0.08). PbtO2 demonstrated a significant increase (p < 0.001), with a noticeable change observed at 10 min after acetazolamide administration (15 [14–17] vs. 28 [26–30] mmHg). Additionally, FVm exhibited a significant increase (p < 0.001), and PI showed a reduction (p < 0.001). Administration of acetazolamide in ABI patients resulted in a significant increase in brain oxygenation, associated with a rise in ICP and FVm, suggesting increased cerebral volume and vasodilation.
Comparison between monotest and traditional batch-based ELISA assays for therapeutic drug monitoring of infliximab and adalimumab levels and anti-drug antibodies
Authors: Moneo Mikel , Ruiz del Agua Ainhoa , Ruiz-Argüello Begoña , Rapun Noelia , Nagore Daniel , El Hamss Rachid 
Published: January 2025

Abstract

Objectives
To compare a new ready-to-use monotest immunoassay, CHORUS Promonitor, for the quantification of serum biological drug levels and anti-drug antibodies of anti-TNF agents, against the reference batch-based ELISA test, Promonitor.

Methods
Blood samples were collected from patients treated with anti-TNF agents, infliximab (IFX) or adalimumab (ADL). IFX and ADL levels, as well as anti-IFX and anti-ADL antibodies were quantified and compared between the standard ELISA reference test, Promonitor, and the automated monotest ELISA assay, CHORUS Promonitor. Data analysis included both qualitative and quantitative comparison between both tests. For the qualitative comparison, overall percent agreement (OPA) was calculated. For the quantitative comparison, Passing-Bablok regression analysis and Bland–Altman analysis were used.

Results
For IFX and ADL levels, the qualitative overall agreement between methods was 100 % (Cohen’s coefficient=1). For anti-IFX and anti-ADL antibodies, OPA was 98.8 % and 97.3 %, respectively. Quantitative comparison indicated a very strong correlation between both assays: IFX (r=0.97, n=74), ADL (r=0.95, n=54), anti-IFX (r=0.93, n=72), and anti-ADL (r=0.97, n=61). The regression analysis determined an excellent comparability of drug levels between methods. Bland–Altman analysis showed a bias difference between assays of 6 % for IFX, 0 % for ADL, 24 % for anti-IFX, and 14 % for anti-ADL.

Conclusions
Monotest CHORUS Promonitor was a reliable assay to quantify IFX, ADL, anti-IFX and anti-ADL in samples with comparable results to those obtained with the reference batch-based ELISA technique.
Efficacy and safety of resmetirom in MASLD and MASH: network meta-analysis of randomized clinical trials
Authors: Ayesh Hazem , Beran Azizullah , Suhail Sajida , Ayesh Suhail , Niswender Kevin 
Published: January 2025

Abstract

Introduction
Metabolic-Associated Steatohepatitis-Related Liver Disease (MASLD) and, its progressive form, Metabolic-Associated Steatohepatitis (MASH) pose significant global health challenges. Current therapeutic strategies targeting metabolic abnormalities have shown promise but lack specificity for the liver. Thyroid hormones, particularly thyroid hormone receptor beta (THR-β) agonists like resmetirom, offer a targeted approach to liver-related pathways.

Content
A network meta-analysis (NMA) comparing different doses of resmetirom to placebo for MASLD and MASH was conducted. PubMed, Scopus, Cochrane, and Web of Science were searched for relevant randomized controlled trials (RCTs). Efficacy outcomes included histological, radiological, and biochemical parameters, while safety outcomes comprised adverse events and treatment discontinuation.

Summary
Resmetirom demonstrated dose-dependent efficacy in histological and radiological assessments, with the 100 mg dose showing superior MASH resolution and hepatic fat reduction. Biochemical markers indicated improved liver function with resmetirom treatment. However, adverse events, particularly diarrhea and nausea, were more prevalent in the resmetirom group, leading to higher treatment discontinuation rates.

Outlook
Resmetirom shows promise as a therapeutic option for MASLD and MASH management, with significant improvements in liver health parameters. However, safety concerns warrant careful monitoring in clinical practice. Further research is needed to optimize its long-term safety and efficacy.
Crystal structure of [μ
2-piperazine-1,4-bis(2-hydroxypropanesulfonato-κ
2
O:O′)] bis(μ
2-4,4′-trimethylenedipyridyl-κ
2
N:N′)disilver(I), C18H24AgN3O4S
Authors: Ma Chaohong , Dong Xianwu , Jiang Jinke , Jiang Hui 
Published: January 2025

Abstract
C18H24AgN3O4S, monoclinic, P21/n (no. 14), a = 10.5522(10) Å, b = 9.4295(6) Å, c = 19.2298(12) Å, β = 95.606(7)°, V = 1904.3(2) Å3, Z = 4, Rgt
(F) = 0.0401, wRref
(F
2) = 0.0959, T = 293(2) K.
Synthesis and crystal structure of 6,6′-((1E,11E)-5,8-dioxa-2,11-diazadodeca-1,11-diene-1,12-diyl) bis(2,4-di-tert-butylphenol), C36H56N2O4
Authors: Zhang Ya-Fang , Zhao Ji-Xing 
Published: January 2025

Abstract
C36H56N2O4, monoclinic, P21/c (no. 14), a = 18.1240(10) Å, b = 17.1409(9) Å, c = 11.3102(6) Å, β = 95.659(2)°, V = 3,496.5(3) Å3, Z = 4, R

gt
(F) = 0.0638, wR

ref
(F
2) = 0.1634, T = 173 K.
A Critical Look at Bilingual Physical Education in Spain
Authors: Martínez-Hita Francisco José 
Published: January 2025

The main objective of the article has been to make a review of the most controversial aspects of bilingual education, mainly focusing on the subject of Physical Education. To this end, a search of the scientific literature was carried out in the main databases (Dialnet, Google Scholar, and SCOPUS) taking into account articles dealing with bilingual education, CLIL and Physical Education. In this way, a series of factors have been found that may go unnoticed and are not politically correct to publish as they are criticisms of the fashionable educational trend, bilingualism. The aspects dealt with are included in the following points: the content of the subject to be taught, motivation problems in students, difficulties and exhaustion on the part of teachers, the questioning of an inclusive school and analysis at a political level. These points are firstly discussed in general terms and, after that, more deeply in relation to the subject of Physical Education. All these aspects show that the Spanish educational system is at a crossroads in which it must reflect on the consequences of these changes and propose new alternatives.
Development of Teacher’s Professional Competence through Action Research as a Form of Professional Development
Authors: Ferencová Janka , Pirohová Ivana , Šuťáková Valentina , Miňová Monika 
Published: January 2025

Action research serves as a significant tool for the professional development of teachers, the enhancement of educational practice, and the advancement of student learning. This review study aims to provide an empirically grounded perspective on action research as a means of stimulating the development of teachers’ professional competence. Drawing upon the analysis of 28 empirical studies from the Scopus, WoS, EBSCO, ProQuest, and Science Direct databases over the past five years, the study identifies the contributions of action research to the development of both core and key professional competences among teachers. The findings confirm that action research not only supports the expansion and deepening of teachers’ knowledge base but also fosters the development of their key professional competences which are vital for effectively addressing the challenges of pedagogical practice. These findings highlight the potential of action research as a form of professional development and its application in establishing teacher professional communities centred on reflection and innovation, aimed at enhancing educational practice and student learning.
Politeness Strategies in Divorce Mediation Within Indonesian Religious Courts
Authors: Swasono Endratno Pilih , Djatmika Djatmika , Sumarlam Sumarlam , Nugroho Miftah 
Published: January 2025

Politeness plays a critical role in divorce mediation within religious courts as it significantly affects the mediator's effectiveness in resolving cases. While Brown and Levinson's theory addresses politeness in general discourse, it does not specifically tackle politeness strategies within the context of divorce mediation in religious courts. This research aims to bridge this gap by investigating politeness strategies in the context of divorce mediation. Data collection was carried out using direct observation and interviews with mediators at the Religious Courts in the Sidoarjo region. The results identify the politeness strategies used by mediators, such as bald on-record, positive politeness, negative politeness, and off-record. An additional politeness strategy, namely sharing story strategy, was also found. Using a case study approach, the research reveals that mediators employ a sharing story strategy to build a sense of empathy, reducing tension and openness to experiences and feelings and promoting understanding and reflection. This strategy also reflects cultural relevance to facilitate successful mediation in divorce cases within religious courts. The factors that influence the use of these strategies, particularly within the context of Indonesian culture, were also explored. The findings contribute conceptually by extending the existing theory and practically by offering insights to enhance communication in mediation processes.
Infratemporal fossa abscess with leptospirosis resembling stroke
Authors: Ealumalai Schandtinie , Lo Ren Hui , Tang Ing Ping , M. Bohari Nursyahirah Sheila Salinah 
Published: January 2025

Infratemporal fossa (ITF) abscess is the formation of abscess in the deep space bounded above by the greater wing of sphenoid and part of temporal bone, medially by later pterygoid of the sphenoid and anteriorly by the posterior surface of the maxilla. We present a rare case of leptospirosis abscess in infratemporal fossa that resembles stroke. Seventy-four-year-old years old gentleman with hypertension presented with 4 days history of left temporal painful swelling. It is associated with fever and reduced oral intake. He started slurring of speech and right upper limb weakness on the day of presentation. On examination, there was a 3×3 cm firm, warm, painful swelling at left temporal region. There was no gag reflex and the patient had right upper limb weakness (3/5). Leptospirosis IgM was positive. CECT brain showed infratemporal fossa collection. Incision and drainage were done with incision made over left temporal swelling guiding to infratemporal fossa. The patient was treated with intravenous ceftriaxone for 10 days and wound dressings. 2 days post operative, all positive neurological signs recovered. ITF abscess with leptospirosis is rare and can have various atypical presentations. Doctors much always remember such possibilities to prevent delay and mismanagement.