bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between higher FFAs and high residual platelet reactivity among CAD patients receiving clopidogrel therapy
Authors: Zhao Zehao , Dong Shutong , Sun Tienan , Han Kangning , Huang Xin , Ma Meishi , Yang Shiwei , Zhou Yujie 
Published: May 2023

BackgroundMetabolic abnormalities are associated with the occurrence, severity, and poor prognosis of coronary artery disease (CAD), some of which affect the antiplatelet efficacy of clopidogrel. Free fatty acids (FFAs) is a biomarker for metabolic abnormalities, and elevated FFAs is observed among CAD patients. Whether FFAs enhances residual platelet reactivity induced by adenosine diphosphate (ADP) while using clopidogrel was unknown. The purpose of our study is exploring the issue.MethodCurrent study included 1,277 CAD patients using clopidogrel and used logistic regression to detect whether the higher level of FFAs is associated with high residual platelet reactivity (HRPR). We additionally performed subgroup and sensitivity analyses to evaluate the stability of the results. We defined HRPR as ADP-induced platelet inhibition rate (ADPi) &lt; 50% plus ADP-induced maximum amplitude (MAADP) &gt; 47 mm.Results486 patients (38.1%) showed HRPR. The proportion of HRPR among patients with higher FFAs (&gt;0.445 mmol/L) is greater than among patients with lower FFAs (46.4% vs. 32.6%, P &lt; 0.001). Multivariate logistic regression demonstrated that higher FFAs (&gt;0.445 mmol/L) is independently associated with HRPR (adjusted OR = 1.745, 95% CI, 1.352–2.254). After subgroup and sensitivity analyses, the results remained robust.ConclusionThe higher level of FFAs enhances residual platelet reactivity induced by ADP and is independently associated with clopidogrel HRPR.
Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia
Authors: Abohamr Samah I. , Abazid Rami M. , Alhumaid Mohammed K. , Abdulrahim Abubaker E. , Aldossari Mubarak A. , Khedr Lamiaa , Werida Rehab H. , Alkheledan Haifa S. , Aleid Yazeed S. , Abdelhamid Sara W. , Al Mefarrej Abdulmohsen , Abdelhamid Ahmed W. , Alaboud Mohammad Hasan , Alhasan Omar T. , Gomaa Hanem M. , Elsheikh Eman 
Published: May 2023

BackgroundRespiratory infections are one of the most common comorbidities identified in hospitalized patients. The coronavirus disease 2019 (COVID-19) pandemic greatly impacted healthcare systems, including acute cardiac services.AimThis study aimed to describe the echocardiographic findings of patients with COVID-19 infections and their correlations with inflammatory biomarkers, disease severity, and clinical outcomes.MethodsThis observational study was conducted between June 2021 and July 2022. The analysis included all patients diagnosed with COVID-19 who had transthoracic echocardiographic (TTE) scans within 72 h of admission.ResultsThe enrolled patients had a mean age of 55.6 ± 14.7 years, and 66.1% were male. Of the 490 enrolled patients, 203 (41.4%) were admitted to the intensive care unit (ICU). Pre-ICU TTE findings showed significantly higher incidence right ventricular dysfunction (28 [13.8%] vs. 23 [8.0%]; P = 0.04) and left ventricular (LV) regional wall motion abnormalities (55 [27.1%] vs. 29 [10.1%]; p &lt; 0.001) in ICU patients compared to non-ICU patients. In-hospital mortality was 11 (2.2%), all deaths of ICU patients. The most sensitive predictors of ICU admission (p &lt; 0.05): cardiac troponin I level (area under the curve [AUC] = 0.733), followed by hs-CRP (AUC = 0.620), creatine kinase-MB (AUC = 0.617), D-dimer (AUC = 0.599), and lactate dehydrogenase (AUC = 0.567). Binary logistic regression showed that reduced LV ejection fraction (LVEF), elevated pulmonary artery systolic pressure, and dilated right ventricle were echocardiographic predictors of poor outcomes (p &lt; 0.05).ConclusionEchocardiography is a valuable tool in assessing admitted patients with COVID-19. Lower LVEF, pulmonary hypertension, higher D-dimer, C-reactive protein, and B-type natriuretic peptide levels were predictors of poor outcomes.
Mid-term safe and effective profile of the Magmaris scaffold in percutaneous coronary intervention: a prospective, single-center study
Authors: Truong Binh Quang , Tran Hoa , Nguyen Vinh Xuan , Nguyen Chinh Duc , Nguyen Khang Duong , Vu Vu Hoang 
Published: May 2023

IntroductionSignificant advances have been made in the diagnosis and treatment of coronary artery disease over the years. New generations of scaffolds containing novel material and eluting drug have produced one of the most significant advancements in coronary intervention. The newest generation would be Magmaris with a magnesium frame and a sirolimus cover.MethodsFrom July 2018 to August 2020, 58 patients treated with Magmaris at the University Medical Center Ho Chi Minh City were enrolled in this study.ResultsA total of 60 lesions were stented, 60.3% of which were left anterior descending (LAD) lesions. There was no in-hospital event. Within 1 year after discharge, we noted one myocardial infarction event that required target-lesion revascularization, one stroke event, one non-target-lesion revascularization patient, two target-vessel revascularization patients, and one in-stent thrombosis. Among them, one myocardial infarction occurrence, one non-target-lesion revascularization, and one in-stent thrombosis event were recorded within the first 30 days after discharge.ConclusionIn conclusion, the Magmaris scaffold is a safe and effective option for structural procedures performed with imaging device support, particularly intravascular ultrasound.
An anesthesia protocol for robust and repeatable measurement of behavioral visceromotor responses to colorectal distension in mice
Authors: Zhang Shaopeng , Chen Longtu , Feng Bin 
Published: May 2023

IntroductionVisceral motor responses (VMR) to graded colorectal distension (CRD) have been extensively implemented to assess the level of visceral pain in awake rodents, which are inevitably confounded by movement artifacts and cannot be conveniently implemented to assess invasive neuromodulation protocols for treating visceral pain. In this report, we present an optimized protocol with prolonged urethane infusion that enables robust and repeatable recordings of VMR to CRD in mice under deep anesthesia, providing a two-hour window to objectively assess the efficacy of visceral pain management strategies.MethodsDuring all surgical procedures, C57BL/6 mice of both sexes (8–12 weeks, 25–35 g) were anesthetized with 2% isoflurane inhalation. An abdominal incision was made to allow Teflon-coated stainless steel wire electrodes to be sutured to the oblique abdominal musculature. A thin polyethylene catheter (Φ 0.2 mm) was placed intraperitoneally and externalized from the abdominal incision for delivering the prolonged urethane infusion. A cylindric plastic-film balloon (Φ 8 mm x 15 mm when distended) was inserted intra-anally, and its depth into the colorectum was precisely controlled by measuring the distance between the end of the balloon and the anus. Subsequently, the mouse was switched from isoflurane anesthesia to the new urethane anesthesia protocol, which consisted of a bout of infusion (0.6 g urethane per kg weight, g/kg) administered intraperitoneally via the catheter and continuous low-dose infusion throughout the experiment at 0.15–0.23 g per kg weight per hour (g/kg/h).ResultsUsing this new anesthesia protocol, we systematically investigated the significant impact of balloon depth into the colorectum on evoked VMR, which showed a progressive reduction with increased balloon insertion depth from the rectal region into the distal colonic region. Intracolonic TNBS treatment induced enhanced VMR to CRD of the colonic region (&gt;10 mm from the anus) only in male mice, whereas colonic VMR was not significantly altered by TNBS in female mice.DiscussionConducting VMR to CRD in anesthetized mice using the current protocol will enable future objective assessments of various invasive neuromodulatory strategies for alleviating visceral pain.
Risk and promise: an 11-year, single-center retrospective study of severe acute GVHD in pediatric patients undergoing allogeneic HSCT for nonmalignant diseases
Authors: Zaidman Irina , Even-Or Ehud , Aharoni Elroee , Averbuch Dina , Dinur-Schejter Yael , NaserEddin Adeeb , Slae Mordechai , Shadur Bella , Stepensky Polina 
Published: May 2023

BackgroundHematopoietic stem cell transplantation (HSCT) is the only curative option for many nonmalignant hematopoietic-derived diseases in pediatric patients. Survival after HSCT has improved in recent years and resulted in a 90% survival rate and cure in some nonmalignant diseases. Graft-vs.-host disease (GVHD) remains a frequent and major complication of HSCT, and a leading cause of morbidity and mortality. Prognosis of patients with high-grade GVHD is dismal, with survival rates varying from 25% in the adult population to 55% in pediatric patients.MethodsThe main aim of this study is to evaluate the incidence, risk factors, and outcome of severe acute GVHD (AGVHD) in pediatric patients with nonmalignant diseases, following allogeneic HSCT. Clinical and transplant data were retrospectively collected for all pediatric patients who underwent allogeneic HSCT for nonmalignant diseases at the Hadassah Medical Center between 2008 and 2019. Patients who developed severe AGVHD were compared with those who did not.ResultsA total of 247 children with nonmalignant diseases underwent 266 allogeneic HSCTs at Hadassah University Hospital over an 11-year period. Seventy-two patients (29.1%) developed AGVHD, 35 of them (14.1%) severe AGVHD (grade 3–4). Significant risk factors for developing severe AGVHD were unrelated donor (p &lt; 0.001), mismatch donor (p &lt; 0.001), and the use of peripheral blood stem cells (PBSCs) (p &lt; 0.001). Survival rates of pediatric patients with severe AGVHD was 71.4%, compared with 91.9% among those with mild (grade 1–2) AGVHD and 83.4% among patients without AGVHD (p = 0.067).ConclusionsThese results demonstrate a high survival rate in pediatric patients with nonmalignant diseases despite severe GVHD. Significant mortality risk factors found in these patients were the source of donor PBSC (p = 0.016) and poor response to steroid treatment (p = 0.007).
The effects of ambient temperature exposure on feline fecal metabolome
Authors: Chiu Olivia , Tal Moran , Sanmugam Abbinash , Hesta Myriam , Gomez Diego E. , Weese Jeffrey Scott , Verbrugghe Adronie 
Published: May 2023

IntroductionThe fecal metabolome provides insight into overall gastrointestinal and microbial health. Methods for fecal sample storage in metabolomics research vary, however, making comparisons within current literature difficult. This study investigated the effect of ambient temperature exposure on microbial-derived metabolites of feline fecal samples.MethodsFecal samples were collected from 11 healthy cats from a local boarding facility. Samples were manually homogenized and aliquoted. The first aliquot was frozen at -80°C within 1 hour of defecation, and remaining samples were exposed to ambient temperature for 2, 4, 6, 8, 12, and 24 h prior to freezing at -80°C. Fecal metabolites were quantified using 1H NMR spectroscopy. Fifty metabolites were grouped into six categories (27 amino acids, 8 fatty acids, 5 sugars, 3 alcohols, 2 nitrogenous bases, 5 miscellaneous).ResultsConcentrations of 20 out of 50 metabolites significantly differed due to ambient temperature exposure (7 amino acids, 6 fatty acids, 2 alcohols, 1 nitrogenous base, 4 miscellaneous). The earliest detected changes occurred 6 h post-defecation for cadaverine and fumaric acid.DiscussionThis study shows ambient temperature exposure alters the composition of the feline fecal metabolome, but short-term (up to 4 h) exposure prior to storage in the freezer seems to be acceptable.
Gender Bias in the Hospitality Sector: Female and Male Jobs
Authors: Silva Susana , Couto Maria João 
Published: May 2023

The hospitality sector is still very traditional and male-dominated in terms of values, it is segregating and discriminatory according to gender, not only horizontally but also vertically, the wage differences between men and women are critical, and many of the jobs are stigmatized. Indeed, despite women representing most of the workforce in hospitality, such numerical dominance is not reflected in the leadership positions they occupy. Traditionally, men and women occupy different roles in the hospitality industry: women are more often assigned functions that are in line with their social roles and that represents an extension of their domestic tasks so that it is easier to find women in-room service or cleaning. Men, on the other hand, are more easily assigned physically demanding tasks, administrative and management functions, which require more skills and are therefore better paid.
This study aims to examine the female and male social representation associated with the performance of certain roles in the hospitality sector, as perceived by tourism and hospitality students, to explore gender representations associated with different hierarchical positions and departments, and to understand some of the (in)equalities that continue to persist between men and women in hospitality.
A quantitative cross-sectional study was performed to achieve the study goals. Our sample consists of 200 higher education students in tourism and hospitality. Based on Bem Sex Role Inventory short-form traits questionnaire, we applied an online questionnaire with the purpose of knowing the students’ gender representations of different professional activities in the hospitality industry.
Within our results, we expect to describe the gender bias of the professional functions in the hospitality sector. On the other hand, we expect to understand possible gender differences between operational and leadership positions, and from different departments.
The findings of this study will help the hotels to analyse their gender practices and policies. By giving voice to the stereotypes that foster gender inequalities in the hospitality sector, hotels can become aware of their gendered practices and policies that impact the recruitment process and the various roles and functions that are assigned to men and women.
Wellness tourism in an active life system and promotion of social cohesion: the case of senior university(s)
Authors: Lopes Eunice , Simões Jorge , Duarte Eunice , Rodrigues José 
Published: May 2023

Recognition of the potential of wellness and quality of life for tourism was manifested by deepening knowledge of this market in the face of the cultural and tourist dynamics developed, but also through the creation of new tourism products specific to this sector and an active lifestyle system. Senior universities, for example, have been playing an increasingly important role in this dynamic of well-being and active life. It has not only promoted activities aimed at the cultural and tourist practice of an active life of well-being but also contributed to the social cohesion of the territory. In this study, carried out geographically in the Centre of Portugal, the aim is to present a case study related to the practice of well-being and active life through the senior university in its relationship with tourism education and the enhancement of the cultural experience. The main objectives of this study are, therefore, the approach to wellness tourism in an active life system and the promotion of social cohesion and by verifying the importance of guaranteeing a healthy life in tourist places that lead people to experience aspects of a healthy lifestyle committed to growing cultural and tourist knowledge. To achieve both objectives, a quantitative analysis was carried out, and from the preliminary results, it is identified that senior universities should, therefore, be understood as social intervention devices. Innovative didactic approaches to teaching end up accompanying the availability of information that facilitates access to knowledge, not least because the new reality contributed by the aging of the population, associated with the process of globalization and the economic and social situation, poses new challenges to the present-day education of well-being, being and quality of life. The conclusions point to favoring the quality of life and social inclusion of those who actively participate in the activities provided by the senior university(s), as active life strategies linked to cultural, wellness, and tourism quality of life, reinforcing the role of social cohesion in the territory in which it operates.
The Real Effectiveness of VR: the tourism and cultural organization managers' point of view
Authors: Wirth Julia , Racine Nina 
Published: May 2023

Abstract: Virtual reality (VR) has become an important field of academic research investigation, firstly and obviously in relation to its technological aspects. Then, as a marketing tool for promotion and communication purposes. In this context, researchers have mainly focused on analyzing the behavior and appreciation of tourists with respect to this new technology. This article proposes an alternative approach, focusing on the company’s decision-makers, mainly tourism and cultural organizations, who use this technology. This approach seeks to understand how and why VR is integrated into a company's strategy. Methodology: Firstly, we did a literature review and studied a systematic collection of virtual tour offers in Switzerland, which led to the analysis of characteristics of these virtual reality offers. These characteristics consider the different virtual reality systems according to the level of immersion, interactivity, and presence, which made it possible to construct a classification of virtual tour offers in Switzerland. Secondly, a qualitative method was used to conduct twelve semi-structured interviews with companies offering virtual tours of Swiss regions, in order to understand the managerial vision of VR usage and to deepen understanding of the various applications of virtual reality in the context of Swiss tourism. Findings: The analysis revealed that there is a distinction between the different virtual reality systems used in the Swiss tourism sector. Research has shown that non-immersive 360° videos as a marketing tool are no longer of great benefit to tourist destinations. Conversely, immersive virtual tours for promotional purposes at trade fairs and with travel partners are still of interest however are no longer considered a competitive advantage. It is the integration of VR into the in-situ tourism experience which has received a more enthusiastic response but creating fears among tourism stakeholders. Originality/Value: The main argument of this article is that it analyzes the use of VR tools from the point of view of managers of cultural and tourist institutions, and not from the point of view of customers. Furthermore, the article proposes a new structural classification of VR projects in Switzerland and offers practical implications for tourism and cultural organizations, as well as new directions for future studies.
The impact of literary festivals on boosting tourist activity: the case of Escritaria
Authors: Ferreira Ana , Villares Marta 
Published: May 2023

The growing awareness towards literary tourism has given it a gradual popularity, strengthening its role in the tourist offer in Portugal. Aware of this fact, we discuss, in this paper, the main initiatives of literary festivals in the country in the city of Penafiel. Experiences, images, and texts are increasingly important to achieve tourist realities. And it is through literary festivals that they are enhanced. Although event tourism has an increasingly interdisciplinary approach, the analysis of the literary experience is still scarce. The main goal of this article is to understand the experience provided by the literary festival ESCRITARIA which took place in 2022, holding its 15th edition. Therefore, a thorough literature review was done, as well as an exploratory and quantitative investigation. In addition, a data collection was carried out with a questionnaire designed to be answered online by the national and international participants in Escritaria. To understand Escritaria as a literary event proposal, one surveyed a sample of national and foreign participants in the festival; since it took place during the event, it allowed one to gauge the importance of literary events as an enhancing offer of the tourist activity. Starting from the sociodemographic profile of the participants, this study aims to understand the forms of participation, involvement and satisfaction. The results of the analysis highlight the growing importance of this type of events and this one, in particular, a festival that has been building loyalty and expanding its audience, an audience of national and international scope. This festival not only increases the number of tourists/visitors, but also enhances the destination promotion and marketing activities.
On the Issue of Premature Birth in Coronavirus Infection
Authors: Свиридова А.В. , Константинова О.Д. 
Published: May 2023

Ведение беременности у пациенток с коронавирусной инфекцией является значительной проблемой для мировой медицины. Доказательств определенного метода и оптимальных сроков родоразрешения для таких пациенток в литературе не представлено, при этом большое внимание уделяется высокому риску преждевременного родоразрешения. В этой связи проведен анализ преждевременных родов, случившихся на фоне коронавирусной инфекции, на базе областного перинатального центра г. Оренбурга. Показатель преждевременных родов среди женщин, родоразрешенных в острый период COVID-19, составил 12,7%. В группу наибольшего риска вошли беременные с тяжелым и крайне тяжелым течением коронавирусной инфекции (с двусторонней пневмонией и дыхательной недостаточностью). В группах сравнения не удалось выявить более предпочтительного метода родоразрешения, что подтверждает индивидуальный подход к родоразрешению в каждом отдельном случае.
Pregnancy management in patients with coronavirus infection is a significant problem for world medicine. There is no evidence of a specific method and optimal delivery dates for such patients in the literature, while much attention is paid to the high risk of premature delivery. In this regard, an analysis of premature births that occurred against the background of coronavirus infection was carried out on the basis of the Regional Perinatal Center in Orenburg. The rate of premature birth among women delivered during the acute period of COVID-19 was 12.7%. The highest risk group included pregnant women with severe and extremely severe coronavirus infection (with bilateral pneumonia and respiratory failure). In the comparison groups, it was not possible to identify a more preferable method of delivery, which confirms an individual approach to delivery in each individual case.
Switchable ferroelectric photovoltaic response in Sc0.2Al0.8N-based optoelectronic devices
Authors: Ma Xiaolong , Zhang Jiahe , Wang Ronghui , Gao Chao , Ma Ye , Lin Binghui , Zou Yang , Liu Yan , Xu Hongxing , Sun Chengliang , Cai Yao 
Published: May 2023

Abstract
Ferroelectric photovoltaic (FePV) materials are naturally considered a new type of solid-state optoelectronic memory conducting with high storage densities and nonvolatile states. This work investigates ferroelectric properties of Sc0.2Al0.8N thin film with a remnant polarization of 225.2 μC cm−2 and researches the switchable FePV effect and photo-diode characteristics of two-terminal Sc0.2Al0.8N devices. When adopting a two-dimensional material MoTe2 to form a heterostructure, both the photo absorption spectrum and the conductivity of ScAlN-based two-terminal device would be promoted, resulting in the photocurrent at the level of μA cm–2. This work suggests ScAlN can provide a promising FePV implementation for constructing high-performance optoelectronics.