bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repercussões do uso de ações educativas mediadas por tecnologias de informação em pacientes com Doença Arterial Coronariana que sofreram eventos isquêmicos: um protocolo de revisão de escopo
Authors: Moura Lyana Reis de , Faria Magda Guimaraes de Araujo , Pena Felipe Montes , Pacheco Fadia Carvalho 
Published: January 2025

Introdução: Frente à prevalência de DCNT que vem ocorrendo nas últimas décadas, nota-se elevado ocorrência da Doença Arterial Coronariana. Mundialmente a DAC tem sido uma das principais causas de morte nos países em desenvolvimento e no Brasil têm representado uma das maiores taxas de morbimortalidade do país. Diante disso, este artigo tem por objetivo identificar as repercussões do uso de medidas educativas mediadas por tecnologia da informação em pacientes com Doença Arterial Coronariana que sofreram eventos isquêmicos. Dessa forma, buscará responder a seguinte pergunta de pesquisa: “Quais as repercussões do uso de ações educativas mediadas por tecnologias de informação em pacientes com Doença Arterial Coronariana que sofreram eventos isquêmicos?” Materiais e métodos: Este trabalho consiste em uma revisão de escopo pautada nas normas do Joanna Briggs Institute (JBI). Serão elencadas para esta pesquisa as bases: EMBASE; MEDLINE VIA PUBMED, Scopus, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web Of Science, Lilacs, Scientific Electronic Library Online (SCIELO); e os Portais: PERIODICOS CAPES e Regional da Biblioteca Virtual de Saúde (BVS REGIONAL). Além disso, a busca por literatura cinzenta ocorrerá na base de dados do google scholar e na Biblioteca Digital de Teses e Dissertações. Resultados esperados: Com este trabalho espera-se sumarizar e entender as repercussões de saúde das medidas educativas mediadas por TIC em pacientes que sofreram eventos isquêmicos de forma a estimular a normatização e uso dessas medidas, corroborando com princípio de prevenção secundária à novos eventos isquêmicos nessa população.
Palavras-chave: Doença Arterial Coronariana; Telessaúde; Ações Educativas Mediadas por Tecnologias de Informação.
Ag85B-Induced M1 Macrophage Polarization via the TLR4/TRAF6/NF-κB Axis Leading to Bronchial Epithelial Cell Damage and TH17/Treg Imbalance
Authors: Zhou Lei , Luo Li , Luo Linzi , Luo Hailong , Ding Yan , Lu Zhibin , Xiao Yangbao 
Published: January 2025

Background:
Antigen 85B (Ag85B) is a signature antigen of
Mycobacterium tuberculosis (MTB). In this study, we aimed to investigate the impact of
macrophages stimulated with Ag85B on bronchial epithelial cells and T cells, as well
as the underlying mechanisms involved.

Methods:
We used Ag85B to stimulate macrophage and investigated the impact of
Ag85B on macrophage polarization. We assessed the impact of TLR4 on Ag85Bmediated
macrophage polarization by silencing TLR4. Additionally, the regulatory role
of TLR4 on the TRAF6/NF-κB pathway was evaluated through immunoblotting.
Activated macrophages with Ag85B were co-cultured with bronchial epithelial cells and
T cells, respectively. Through immunoblotting quantification, biochemical methods, and
flow cytometry, we explored the effects and molecular mechanisms of Ag85B-induced
macrophage activation on bronchial epithelial cell damage and T-cell transformation.

Results:
In macrophages stimulated with Ag85B, levels of M1 polarization-related
genes (CXCL9, CXCL10, and iNOS) and cytokines (IL-6, TNF-α, IL-1β, and IL-12)
were increased, and the M1/M2 ratio was elevated. TLR4 silence inhibited the effects
of Ag85B on macrophages and decreased TRAF6 and p-NF-κB/NF-κB levels. TRAF6
overexpression reversed the inhibitory effect of TLR4 on macrophage stimulation with
Ag85B. After co-culturing with macrophages induced by Ag85B, MBEC cell
proliferation was inhibited, apoptosis was promoted, and the TH17/Treg ratio of T cells
was increased. Silencing TLR4 reversed the impact of Ag85B-induced macrophage
polarization on bronchial epithelial cells and T cells, which was further reversed by
TRAF6 overexpression.

Conclusion:
Ag85B promoted M1 polarization in macrophages through the
TLR4/TRAF6/NF-κB axis, resulting in bronchial epithelial cell damage and an
imbalance in TH17/Treg cells.
Thymoquinone-PLGA-PF68 Nanoparticles Induce S Phase Cell Cycle Arrest and Apoptosis, Leading to the Inhibition of Migration and Colony Formation in Tamoxifen-Resistant Breast Cancer Cells
Authors: Noor Nurul Shahfiza , Hamid Shahrul Bariyah Sahul 
Published: January 2025

Background:
A biocompatible polymeric nanoparticle, TQ-PLGA-PF68,
was developed through the interaction of the phytochemical thymoquinone (TQ)
encapsulated in poly(L-lactide-co-glycolide)-b-poly(ethylene glycol) (PLGA-PEG) with
Pluronics F68. So far, this combination has not been assessed on breast cancer cells
resistant to anti-cancer drugs. Therefore, this study aimed to assess the cell death
caused by TQ-PLGA-PF68 nanoparticles, particularly in resistant breast cancer cell
lines expressing estrogen receptor (ER) positivity, such as TamR MCF-7.

Methods:
The antiproliferative activity of TQ-PLGA-PF68 nanoparticles was measured
using the MTS assay. The cytotoxic effects were further evaluated through colony
formation assay and scratch-wound healing assay. Terminal deoxynucleotidyl
transferase dUTP Nick End Labeling (TUNEL) assay was performed to determine the
characteristics of the apoptosis as well as cell cycle arrest induced by TQ-PLGA-PF68
nanoparticles. The localization of these nanoparticles in the cells was examined using
Transmission Electron Microscopy (TEM).

Results:
With a TQ concentration of 58.5 μM encapsulated within the nanoparticles,
cytotoxicity analysis revealed a significant inhibition of cell proliferation (p<0.05). This
finding was corroborated by the results of the colony formation assay. Treatment with
TQ-PLGA-PF68 nanoparticles significantly decreased the number of surviving TamR
MCF-7 cells by 35% (p<0.001) compared to untreated TamR MCF-7 cells.
Concurrently, the scratch-wound healing assay indicated a closure rate of 50% versus
>80% (p<0.05) in untreated TamR MCF-7 cells at 12 hours post-wounding. The
TUNEL assay successfully confirmed the apoptosis characteristics associated with cell
cycle arrest. TEM observation confirmed the cellular internalization of these
nanoparticles, suggesting the in vitro therapeutic potential of the formulation.

Conclusion:
In this study, a significant functional change in TamR MCF-7 cells
induced by the TQ nanoparticles was observed. The unique incorporation of TQ into
the PLGA-PEG and Pluronics F68 formulation preserved its bioactivity, thereby
reducing the migratory and proliferative traits of drug-resistant cells. This discovery
may pave the way for exploring the application of biocompatible polymeric TQ
nanoparticles as a novel therapeutic approach in future studies pertaining to resistant
breast cancer.
A Comprehensive Review of Aloe vera: Composition, Properties, Processing, and Applications
Authors: Sharma Parul , Kaur Ramandeep 
Published: January 2025

Abstract:
Aloe vera, a drought-resistant succulent, is renowned for its wide-ranging medicinal properties.
It has significant health benefits, including anticancer, wound and burn healing, hypoglycemic,
gastroprotective, antifungal, and antiinflammatory properties. These properties have led to its
use in various commercial applications, particularly in skincare, cosmetics, and medicinal products.
Additionally, Aloe vera is increasingly employed as an edible coating for fruits and vegetables,
providing a natural alternative to postharvest chemical treatments. This review highlights Aloe vera's
diagnostic properties and diverse applications, focusing on its rich polysaccharides, enzymes, vitamins,
and minerals composition. Advances in analytical chemistry are enhancing the chemical characterization
of Aloe vera, promising more information and broader applications shortly. The study
also explores the plant's processing into juice, concentrate, and powder forms, underscoring its extensive
use in pharmaceuticals, cosmetics, and functional foods, particularly for its antioxidant and
anti-inflammatory benefits.
Resiliensi pelajar komunitas Kawruh Jiwa dalam menghadapi pandemi COVID-19
Authors: Rahmadi Sidiq , Aji Danang Bimo , Lestari Sri 
Published: January 2025

Simpang siur Informasi tentang COVID-19 menimbulkan kepanikan dan tekanan psikologis. Kesadaran terhadap realitas dan resiliensi penting dalam menghadapi situasi yang tidak menentu. Penelitian ini bertujuan mengetahui resiliensi para pelajar komunitas Kawruh Jiwa dalam menghadapi pandemi. Metode penelitian kualitatif fenomenologi deskriptif dengan teknik pengumpulan data wawancara semi terstruktur dan kajian literatur. Informan penelitian ini dua orang yang dengan usia 51 dan 45 tahun. Data dianalisis secara tematik, dengan memahami, menganalisis dan menentukan tema coding apriori. Hasil penelitian ini mengungkap bahwa ajaran Kawruh Jiwa memiliki peran kontrol diri saat menghadapi realita yang dihadapi dengan cara mikir leres (berpikir benar), ngudari raribet (memecahkan masalah), mengenal rasa (mengenal rasa sendiri dan orang lain), tatag (tangguh) dan mawas diri (introspeksi diri) yang diterapkan oleh pelajar Kawruh Jiwa dapat mengembangkan resiliensi ketika menghadapi pandemi COVID-19.
The Hegemony of Financial Experts and Big Global Banks: a Critical Analysis of International Banking Rules
Authors: Ramírez Ortiz Derzu Daniel 
Published: January 2025

This article provides a critical political economy analysis of global banking regulations formulated by the Basel Committee and the Financial Stability Board. By examining the political bias in rules that appear neutral, elucidating the intellectual leadership exercised by technocratic spaces where these banking regulations are developed, and exploring the legitimacy these spaces and regulations gain among key stakeholders, it argues that the prevailing economic discourse in these regulations, though seemingly apolitical, aligns with the consolidation of a hegemonic structure that favors banks deemed too big to fail.
Resumen

Este artículo ofrece una lectura crítica de economía política sobre las normas bancarias globales formuladas en el Comité de Basilea y el Consejo de Estabilidad Financiera. Al examinar el sesgo político en reglas que aparentan ser neutrales, dilucidar el liderazgo intelectual de los espacios tecnocráticos donde se desarrollan dichas normas, y analizar la legitimidad que estos espacios y sus normas adquieren frente a actores clave, se argumenta que el discurso económico dominante en estas regulaciones, aunque aparentemente apolítico, está alineado con la consolidación de una estructura hegemónica que favorece a los bancos demasiado grandes para quebrar.
Antimicrobial Activities of Citrus Seed and Leaf Extracts Against Selected Bacterial and Fungal Pathogens Linked to Human Diseases: In vitro Experimental Study in Musanze, Rwanda
Authors: Uwumuremyi Fabrice , Ndikumana Ferdinand Gahungu , Mutijima Jean Berchmas , Mpinganzima Lydivine , Habyarimana Thierry , Niyonzima Francois Niyongabo Niyonzima 
Published: January 2025

Antimicrobial resistance has caused major challenges in both bacterial and fungal infections. Therefore, the current study was designed to evaluate the antimicrobial activity with different crude extracts of leaves and seeds of Citrus limon against Gram-positive (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa) and fungi (Cryptococcus neoformans and Candida albicans) obtained from different clinical settings. Filtrate extracts after maceration technique and the phytochemical substances detected in plants were flavonoid, saponin, alkaloid, glycoside, and resin under investigation. In vitro, a disc diffusion assay was applied to measure the inhibition zone of the plant effect in millimeters (mm). It was observed that Citrus limon activity showed the highest on ethanolic seed against Staphylococcus aureus and the lowest activity plant observed on methanolic leaf extract against Klebsiella oxytoca. The mean values of Citrus limon extract convinced there was no statistically significant correlation among extract solvents used in the study (ρ > 0.05). Oxacillin was used as the positive control and discs without antibiotic content as the negative control during testing. To conclude, ethanolic seed extract has shown the highest effect against Staphylococcus aureus and Salmonella typhi from isolate. Indeed, plant extracts that showed potential effectiveness, such as (Citrus leaves and seeds) can be used as natural alternative preventive measures to control pathogenic bacterial diseases and prevent the rise of antibiotic resistance. Furthermore, studies to evaluate the in vivo potential in an animal model are recommended.
Keywords: Citrus limon, Crude extract, Bacteria, Fungi, Antimicrobial resistance.
Formulation And Evaluation of Betulinic Acid Loaded Transdermal Patches
Authors: Kumar Manmeet , Bose Prashanta , Singh Amar Pal , Singh Ajeet Pal 
Published: January 2025

Many disorders, including cardiovascular diseases, Parkinson's disease, Alzheimer's disease, fungal diseases, depression, anxiety, and Attention Deficit Hyperactivity Disorder (ADHD), skin cancer, female sexual dysfunction, post-menopausal bone loss, and urine incontinence, can now be treated with transdermal delivery systems. A naturally occurring pentacyclic triterpenoid, betulinic acid possesses antiretroviral, antimalarial, and anti-inflammatory qualities. More recently, it has been shown to have anticancer potential through topoisomerase inhibition. The goal of the current study was to create transdermal patches with a controlled release action that included several polymers and an anti-inflammatory medication, such as betulinic acid..The solvent evaporation approach was successfully used to create the betulinic acid transdermal patch. Betulinic acid transdermal patches for transdermal medication administration were assessed. A calibration curve was acquired, a transdermal film was made, and the drug's bioavailability constraints were addressed.
Keywords: Controlled DDS, Transdermal DDS, Betulinic acid, Transdermal Patch, solvent evaporation method.
Adhering to Regulatory Requirements in Calculation of Earthquake Resistance of the Structures of Life-Saving Buildings
Authors: Mazhiev Kh. N. , Mazhiev K. Kh. , Panasenko Yu. V. , Mazhieva A. Kh. , Mazhiev A. Kh. , Mazhiev A. Kh. 
Published: January 2025

Introduction. The scientific problem lies in ensuring earthquake resistance of the buildings by optimizing design solutions, selecting the computational models and developing a methodology, which takes into account the nonlinear behaviour of the load bearing structures under the action of design-earthquakes and reference-earthquakes. For adhering to regulatory requirements in calculation of earthquake resistance of the structures of life-saving buildings, the nonlinear calculations of structures’ behaviour under intense seismic actions were made.Materials and Methods. The calculations were made by the analytical method and the finite element method using the “STARK ES” and “LIRA-SAPR” software.Results. The comparative computation results of the estimated multi-storey building dynamic model subject to the horizontal progressive dynamic action with the use of eigenforms in a linear formulation have been obtained. In addition, the results of dynamic calculation under the main and special combination of loads and corresponding combination of internal forces performed for the estimated structures of a multi-storey building with seismic isolation constructed in Grozny have been presented.Discussion and Conclusion. The criteria for selecting the significant and excluding the insignificant forms of natural oscillations when performing the earthquake resistance calculations of structures with certain nonlinearities have been determined. The calculation results have demonstrated achievement of the required bearing capacity of a multi-storey building in the given calculation conditions.
IMPLEMENTASI CHATBOT PADA PENERIMAAN MAHASISWA BARU DI POLITEKNIK TEDC BANDUNG MENGGUNAKAN NATURAL LANGUAGE PROCESSING
Authors: Rahmawati Hani , Sudrajat Ari 
Published: January 2025

Chatbot adalah program komputer yang mampu melakukan percakapan seperti halnya manusia. Model percakapan menggunakan kecerdasan buatan untuk memahami pertanyaan pengguna dan memberikan respons yang sesuai dengan topik yang dibahas. Proses penerimaan mahasiswa baru memerlukan layanan informasi yang cepat dan efisien, website penerimaan mahasiswa baru di Politeknik TEDC Bandung masih sebatas berisi informasi umum. Penelitian ini bertujuan untuk membuat suatu aplikasi chatbot yang dapat menjawab pertanyaan dari calon mahasiswa seputar penerimaan mahasiswa baru di Politeknik TEDC Bandung. Aplikasi chatbot diimplementasikan menggunakan metode Natural Language Processing (NLP). Tahapan pada NLP terdiri dari pembuatan dataset, text preprocessing, bag of word (BoW), dan model neural network. pelatihan pada model dilakukan sebanyak 450 epoch dan mendapatkan hasil dengan final loss 36,85% dan accuracy sebesar 90,77%. Hasil pengujian User Acceptance Test (UAT) pada Aplikasi Chatbot Penerimaan Mahasiswa Baru di Politeknik TEDC Bandung terbukti dapat diterima dengan baik oleh pengguna, dengan nilai persentase mencapai 89,78%.
RANCANG BANGUN SISTEM PENDETEKSI KEBOCORAN GAS BERBASIS IOT
Authors: Nurhapsari Nurhapsari , Paembonan Solmin , Suppa Rinto 
Published: January 2025

Gas adalah salah satu jenis bahan yang banyak dimanfaatkan oleh manusia dalam menunjang kehiduapan sehari-hari. Beberapa jenis gas memiliki sifat mudah terbakar seperti gas LPG. Sehingga kebocoran gas membutuhkan penanganan yang cepat karena kebocoran gas memiliki resiko yang tinggi sebagai penyebab kebakaran. Tujuan dari penelitian ini adalah membuat rangkaian alat yang dapat mendeteksi kebocoran tabung gas dan kebakaran dari jarak jauh menggunakan koneksi internet. Metode pengumpulan data dalam penelitian ini adalah metode literatur dan uji coba alat. Alat yang digunakan dalam membangun prototype ini adalah sensor MQ-6, nodemcu, buzzer, lcd, flame sensor, adaptor, relay, blynk. Penelitian ini menghasilkan rancang bangun sistem yang dapat mendeteksi kebocoran gas dan kebakaran yang memberikan notifikasi atau pemberitahun ke handphone menggunakan jaringan internet.Keywords: kebocoran gas, internet of things, blynk, nodeMCU esp8266.
SISTEM PENDUKUNG KEPUTUSAN REKOMENDASI PEMILIHAN MOBIL BEKAS MENGGUNAKAN METODE SIMPLE ADDITIVE WEIGHTING (SAW)
Authors: Munir Masdir , Muhallim Muhlis , Mukramin Mukramin 
Published: January 2025

Penelitian ini bertujuan untuk merancang sebuah Sistem Pendukung Keputusan (SPK) untuk rekomendasi pemilihan mobil bekas menggunakan metode Simple Additive Weighting (SAW). Sistem ini dirancang untuk membantu pihak showroom dalam menentukan rekomendasi mobil bekas yang memenuhi kriteria yang telah ditentukan secara objektif. Kriteria penilaian meliputi merk, harga, tahun, tipe bahan bakar, warna, transmisi, kapasitas penumpang. Metode SAW digunakan untuk melakukan perangkingan berdasarkan bobot dari setiap kriteria yang diperoleh melalui wawancara dengan pemilik showroom. Hasil dari penelitian ini menunjukkan bahwa sistem yang dibangun dapat memberikan rekomendasi terbaik berdasarkan perhitungan yang akurat dan transparan, sehingga membantu pengambilan keputusan yang lebih efektif dan efisien. Keywords: Sistem Pendukung Keputusan, Simple Additive Weighting, Mobil Bekas.
IMPELEMENTASI JARINGAN INTERNET MENGGUNAKAN PLC (POWER LINE COMUNICATION) PADA FAKULTAS TEKNIK UNIVERSITAS ANDI DJEMMA
Authors: Ifrain Ifrain , Dasril Dasril , Muhallim Muhlis 
Published: January 2025

Sistem load balancing merupakan salah satu teknik untuk mendistribusikan beban jaringan secara merata di antara beberapa server atau jalur akses internet, dengan tujuan meningkatkan efisiensi dan kinerja jaringan. Pada penelitian ini, diterapkan metode Impelementasi Jaringan Internet Menggunakan Plc (Power Line Comunication) Pada Fakultas Teknik Universitas Andi Djemma. PLC adalah metode yang membagi lalu lintas jaringan berdasarkan koneksi individual, sehingga memungkinkan pengelolaan distribusi beban yang lebih efisien dan tepat sasaran. Dengan menggunakan metode ini, setiap koneksi akan diarahkan ke jalur yang berbeda sesuai dengan karakteristik dan kebutuhan koneksi tersebut. Hasil dari implementasi ini menunjukkan bahwa metode PLC mampu meningkatkan kualitas layanan Teknik Universitas Andi Djemma, terutama dalam hal stabilitas koneksi dan efisiensi penggunaan bandwidth. Analisis kinerja yang dilakukan meliputi pengukuran throughput, latency, dan packet loss. Kesimpulannya, metode PLC terbukti efektif dalam mendistribusikan beban jaringan secara dinamis dan adaptif, sehingga meningkatkan kinerja keseluruhan jaringan sekolah. Keywords: Impelementasi, Jaringan Internet, Plc (Power Line Comunication).
PREDIKSI CHURN PELANGGAN PADA LAYANAN DESAIN GRAFIS HOME DESAIN MENGGUNAKAN ALGORITMA NAÏVE BAYES
Authors: DAIPAH IIP IMRON , ASTUTI RINI , PRIHARTONO WILLY 
Published: January 2025

Abstrak. Penelitian ini bertujuan untuk mengembangkan model prediksi churn pelanggan di Home Desain menggunakan algoritma Naïve Bayes. Dataset yang digunakan mencakup data transaksi dari tahun 2021 hingga 2024, dengan fitur-fitur seperti jenis layanan, jumlah revisi, harga, status pembayaran, kategori revisi, dan keterlambatan pembayaran. Proses analisis mengikuti tahapan dalam metode Knowledge Discovery in Databases (KDD), yang mencakup seleksi, praproses, transformasi data, pembuatan model, dan evaluasi. Pada tahap seleksi data, fitur yang relevan dengan churn pelanggan dipilih, sementara praproses dilakukan untuk memastikan konsistensi data. Transformasi data digunakan untuk mempersiapkan data sebelum dimasukkan ke dalam model prediksi. Model dikembangkan menggunakan algoritma Naïve Bayes, yang terbukti efektif dalam menangani data besar dan masalah klasifikasi. Hasil evaluasi menunjukkan bahwa model yang dikembangkan memiliki performa sangat baik, dengan akurasi 99%, presisi 1.00, recall 0.99, dan F1-score 0.99, yang menandakan bahwa model ini sangat handal dalam mengidentifikasi pelanggan yang berisiko churn. Temuan ini membuktikan bahwa Naïve Bayes adalah alat yang efektif dalam merancang strategi retensi yang lebih efisien, serta berguna bagi perusahaan di sektor jasa kreatif untuk meningkatkan pengambilan keputusan berbasis data. Penelitian ini memberikan kontribusi signifikan terhadap literatur mengenai penggunaan algoritma prediktif dalam industri kreatif, membuktikan bahwa Naïve Bayes dapat diandalkan dalam menganalisis data besar dan memprediksi churn pelanggan dengan akurasi tinggi. Temuan ini juga membantu perusahaan merancang strategi yang lebih efektif untuk mempertahankan pelanggan dan meningkatkan daya saing pasar.