bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telemedicine for the management of diabetic patients in a high-complexity Latin American hospital
Authors: Casas Luz Angela , Alarcón Juliana , Urbano Alejandra , Peña-Zárate Evelyn E. , Sangiovanni Saveria , Libreros-Peña Laura , Escobar María Fernanda 
Published: April 2023

Abstract
Background
Noncommunicable diseases such as diabetes mellitus (DM) have gained attention worldwide. Latin America experienced a rise in rates of DM. During the COVID-19 pandemic, a telemedicine program was implemented in a quaternary care academic complex in Latin America to continue the follow-up of patients with diabetes.

Objective
The aim of this study is to describe the clinical experience of DM patient management through telemedicine and the HbA1c behavior of patients followed-up through this modality.

Materials and methods
We conducted a retrospective cohort study including all patients with type 1 or 2 diabetes who were treated via telemedicine from March to December 2020. A Wilcoxon statistical test was used to compare the changes in glycosylated hemoglobin between the first teleconsultation and after 6 months of telemedicine follow-up.

Results
A total of 663 patients were included, 17.65% (117) of whom had type 1 diabetes and 82.35% (546) of whom had type 2 diabetes. Patients with both types of diabetes, presented with stable HbA1c values regardless of the length of follow-up.

Conclusion
The use of telemedicine can be a helpful tool for both patients and health care providers to support the continuity of care to maintain acceptable control levels within glycemic control goals.
Patient perspectives on data sharing regarding implementing and using artificial intelligence in general practice – a qualitative study
Authors: Mikkelsen Josefine Graabaek , Sørensen Natasha Lee , Merrild Camilla Hoffmann , Jensen Martin Bach , Thomsen Janus Laust 
Published: April 2023

Abstract
Background
Due to more elderly and patients with complex illnesses, there is an increasing pressure on the healthcare system. General practice especially feels this pressure as being the first point of contact for the patients. Developments in digitalization have undergone fast progress and data-driven artificial intelligence (AI) has shown great potential for use in general practice. To develop AI as a support tool for general practitioners (GPs), access to patients’ health data is needed, but patients have concerns regarding data sharing. Furthermore, studies show that trust is important regarding the patient-GP relationship, data sharing, and AI. The aim of this paper is to uncover patient perspectives on trust regarding the patient-GP relationship, data sharing and AI in general practice.

Method
This study investigated 10 patients’ perspectives through qualitative interviews and written vignettes were chosen to elicit the patients (interviewees) perspectives on topics that they were not familiar with prior to the interviews. The study specifically investigated perspectives on 1) The patient-GP relationship, 2) data sharing regarding developing AI for general practice, and 3) implementation and use of AI in general practice using thematic analysis. The study took place in the North Denmark Region and the interviewees included had to be registered in general practice and be above 18 years in age. We included four men between 25 to 74 years in age and six women between 27 to 46 years in age.

Results
The interviewees expressed a high level of trust towards their GP and were willing to share their health data with their GP. The interviewees believed that AI could be a great help to GPs if used as a support tool in general practice. However, it was important for the interviewees that the GP would still be the primary decision maker.

Conclusion
Patients may be willing to share health data to help implement and use AI in general practice. If AI is implemented in a way that preserves the patient-GP relationship and used as a support tool for the GP, our results indicate that patients may be positive towards the use of AI in general practice.
Intrinsic signalling factors associated with cancer cell-cell fusion
Authors: Dittmar Thomas , Hass Ralf 
Published: April 2023

AbstractCellular fusion e.g. between cancer cells and normal cells represents a stepwise process that is tightly regulated. During a pre-hybrid preparation program somatic cells and/or cancer cells are promoted to a pro-fusogenic state as a prerequisite to prepare a fusion process. A pro-fusogenic state requires significant changes including restructure of the cytoskeleton, e.g., by the formation of F-actin. Moreover, distinct plasma membrane lipids such as phosphatidylserine play an important role during cell fusion. In addition, the expression of distinct fusogenic factors such as syncytins and corresponding receptors are of fundamental importance to enable cellular mergers. Subsequent hybrid formation and fusion are followed by a post-hybrid selection process. Fusion among normal cells is important and often required during organismal development. Cancer cells fusion appears more rarely and is associated with the generation of new cancer hybrid cell populations. These cancer hybrid cells contribute to an elevated tumour plasticity by altered metastatic behaviour, changes in therapeutic and apoptotic responses, and even in the formation of cancer stem/ initiating cells. While many parts within this multi-step cascade are still poorly understood, this review article predominantly focusses on the intracellular necessities for fusion among cancer cells or with other cell populations of the tumour microenvironment.
Definition, harms, and prevention of redundant systematic reviews
Authors: Puljak Livia , Lund Hans 
Published: April 2023

Abstract
Background
Along with other types of research, it has been stated that the extent of redundancy in systematic reviews has reached epidemic proportions. However, it was also emphasized that not all duplication is bad, that replication in research is essential, and that it can help discover unfortunate behaviors of scientists. Thus, the question is how to define a redundant systematic review, the harmful consequences of such reviews, and what we could do to prevent the unnecessary amount of this redundancy.

Main body
There is no consensus definition of a redundant systematic review. Also, it needs to be defined what amount of overlap between systematic reviews is acceptable and not considered a redundancy. One needs to be aware that it is possible that the authors did not intend to create a redundant systematic review. A new review on an existing topic, which is not an update, is likely justified only when it can be shown that the previous review was inadequate, for example, due to suboptimal methodology. Redundant meta-analyses could have scientific, ethical, and economic questions for researchers and publishers, and thus, they should be avoided, if possible. Potential solutions for preventing redundant reviews include the following: (1) mandatory prospective registration of systematic reviews; (2) editors and peer reviewers rejecting duplicate/redundant and inadequate reviews; (3) modifying the reporting checklists for systematic reviews; (4) developing methods for evidence-based research (EBR) monitoring; (5) defining systematic reviews; (6) defining the conclusiveness of systematic reviews; (7) exploring interventions for the adoption of methodological advances; (8) killing off zombie reviews (i.e., abandoned registered reviews); (9) better prevention of duplicate reviews at the point of registration; (10) developing living systematic reviews; and (11) education of researchers.

Conclusions
Disproportionate redundancy of the same or very similar systematic reviews can lead to scientific, ethical, economic, and societal harms. While it is not realistic to expect that the creation of redundant systematic reviews can be completely prevented, some preventive measures could be tested and implemented to try to reduce the problem. Further methodological research and development in this field will be welcome.
A cloud-oriented siamese network object tracking algorithm with attention network and adaptive loss function
Authors: Sun Jinping , Li Dan 
Published: April 2023

AbstractAiming at solving the problems of low success rate and weak robustness of object tracking algorithms based on siamese network in complex scenes with occlusion, deformation, and rotation, a siamese network object tracking algorithm with attention network and adaptive loss function (SiamANAL) is proposed. Firstly, the multi-layer feature fusion module for template branch (MFFMT) and the multi-layer feature fusion module for search branch (MFFMS) are designed. The modified convolutional neural networks (CNN) are used for feature extraction through the fusion module to solve the problem of features loss caused by too deep network. Secondly, an attention network is introduced into the SiamANAL algorithm to calculate the attention of template map features and search map features, which enhances the features of object region, reduces the interference of background region, and improves the accuracy of the algorithm. Finally, an adaptive loss function combined with pairwise Gaussian loss function and cross entropy loss function is designed to increase inter-class separation and intra-class compactness of classification branches and improve the accuracy rate of classification and the success rate of regression. The effectiveness of the proposed algorithm is verified by comparing it with other popular algorithms on two popular benchmarks, the visual object tracking 2018 (VOT2018) and the object tracking benchmark 100 (OTB100). Extensive experiments demonstrate that the proposed tracker achieves competitive performance against state-of-the-art trackers. The success rate and precision rate of the proposed algorithm SiamANAL on OTB100 are 0.709 and 0.883, respectively. With the help of cloud computing services and data storage, the processing performance of the proposed algorithm can be further improved.
Personality traits and perceived cognitive function in lebanese healthcare professionals
Authors: Moussa Sara , Achkouty Iris , Malaeb Diana , Ghosn Anthony , Obeid Sahar , Hallit Souheil 
Published: April 2023

Abstract
Background
The healthcare field, a well-known field associated with variety of stressors, leaves healthcare professionals at an increased risk of both physical and mental problems. COVID-19 pandemic has recently been added to the stressful factors by endangering further the cognitive function of healthcare workers. On another hand, personality traits have been shown to have pervasive associations with functioning across various cognitive domains. Thus, this study aims to evaluate association between personality traits and perceived cognitive function among healthcare professionals in Lebanon during the collapsing period (following the severe economic crisis and the COVID-19 pandemic).

Methods
This cross-sectional study was conducted between November 2021 and January 2022 enrolled 406 Lebanese participants using the convenience sampling technique for data collection. Healthcare professionals from all specialties who received the online link to the survey were eligible to participate. The Big Five Inventory-2 (BFI-2) and Fact Cog scale were used to assess personality traits and cognitive function.

Results
After adjustment over all variables (age, gender, household crowding index, physical activity index, marital status, profession and the other four personality traits), higher negative emotionality was significantly associated with a worse cognitive function, whereas more extroversion and conscientiousness were significantly associated with a better cognitive function.

Conclusion
Our study adds to the narrow body of research revolving around the relationship between personality traits and perceived cognitive function in Lebanese healthcare professionals during these hard times in Lebanon. These results show that the choice of these cognitive processes is strongly affected by different personality traits, such as extroversion, conscientiousness, and negative emotionality. This study encourages the need to conduct further research that assess the changes in cognition in life stressors along with personality traits.
A rise in social media use in adolescents during the COVID-19 pandemic: the French validation of the Bergen Social Media Addiction Scale in a Canadian cohort
Authors: Rouleau Raphaël Dufort , Beauregard Carmen , Beaudry Vincent 
Published: April 2023

AbstractIntroductionSocial media use has grown dramatically since its inception in the early 2000s and has further increased during the COVID-19 pandemic. Problematic use of social media (PUSM) is a type of behavioural addiction which has generated increasing interest among mental health clinicians and scholars in the last decade. PUSM is associated with multiple psychiatric conditions and is known to interfere with patients’ daily functioning. There is no single accepted definition of PUSM, nor means of measuring it, in the literature. The Bergen Social Media Addiction Scale (BSMAS) is a helpful tool for identifying PUSM. This paper aims to validate BSMAS and to translate it from English into French, with the goal of making this clinical screening tool for PUSM available in French-language contexts.MethodThis study explored the psychometric validity of the French version of the BSMAS in a sample of 247 adolescents, who were either psychiatric inpatients (the hospitalized group, n = 123) or recruited in local high schools (the community group, n = 124).ResultsThe adolescents in the sample reported an increase in their social media use during the COVID-19 pandemic. This increase was more pronounced in the hospitalized group. Confirmatory factorial analysis showed an excellent fit, very good internal consistency and established convergent validity for the French version of the BSMAS. A total of 15.4% of the hospitalization group and 6.5% of the community group met the recommended clinical cutoff of 24 on the BSMAS, suggesting problematic use of social media.ConclusionsThe French version of BSMAS is a psychometrically validated and clinically useful tool to screen for PUSM in adolescents.
Selective serotonin reuptake inhibitors and suicidality in children and young adults: analyses of pharmacovigilance databases
Authors: Dubrall Diana , Fekete Stefanie , Leitzen Sarah , Paschke Lena Marie , Romanos Marcel , Schmid Matthias , Gerlach Manfred , Sachs Bernhardt 
Published: April 2023

Abstract
Background
Since the warnings by the United States (US) and European regulatory authorities in 2004 and 2005 it had been discussed whether there is some link between selective serotonin reuptake inhibitors (SSRIs) and suicidality in the pediatric population. The aim of our study was to describe trends and patterns in spontaneous reporting data referring to suicidality in children, adolescents and young adults treated with SSRI after the warnings.

Methods
Descriptive analyses of reports for 0–24 year olds referring to suicide/suicidal ideations, self-harms and overdoses with SSRIs reported as suspected submitted to the US (FAERS) and the European (EudraVigilance) adverse drug reaction databases until 2019 were performed. The causal relationship was assessed in accordance with the WHO criteria for the European reports. For Germany, prescription data for SSRIs were provided and reporting rates (number of reports/number of prescriptions) were calculated for the reports with possible causal relationship (so called “confirmed reports”).

Results
Since 2004, the number of reports referring to suicide/suicidal ideations, self-harm and overdoses increased steadily in the US and EU. However, only a slight increase was seen for the confirmed EU reports. After 2008, the proportion of reports informing about suicidal ideations increased, while the proportion of fatal suicide attempts decreased. Reporting rates were higher for females and adolescents (12-18 years).

Conclusions
Our results demonstrate the importance of further monitoring suicidality in 0–24 year olds treated with SSRI in order to recognize suicidality early avoiding fatal suicide attempts. The higher reporting rates for females and adolescents should be further investigated.
Predictive factors for treatment outcomes with intravitreal anti-vascular endothelial growth factor injections in diabetic macular edema in clinical practice
Authors: Gurung Rajya L , FitzGerald Liesel M , Liu Ebony , McComish Bennet J , Kaidonis Georgia , Ridge Bronwyn , Hewitt Alex W , Vote Brendan J , Verma Nitin , Craig Jamie E , Burdon Kathryn P 
Published: April 2023

AbstractBackgroundIntravitreal anti-vascular endothelial growth factor (anti-VEGF) injections are the standard of care for diabetic macular edema (DME), a common complication of diabetes. This study aimed to identify factors influencing DME intravitreal anti-VEGF treatment outcomes in real-world practice.MethodsThis was a multi-center retrospective observational study using medical chart review of participants receiving anti-VEGF injections for DME (N = 248). Demographic and clinical variables were assessed for association with best corrected visual acuity (BCVA) and central macular thickness (CMT) outcomes using regression models.ResultsThere was a significant improvement in BCVA (p < 0.001) and CMT (p < 0.001) after 12 months of treatment, although 21% of participants had decreased BCVA, and 41% had a < 10% CMT reduction at 12 months. Higher baseline BCVA (p = 0.022, OR=-0.024, 95% CI=-0.046,-0.004) and longer duration of diabetic retinopathy (p = 0.048, OR=-0.064, 95% CI=-0.129,-0.001) were negative predictors for BCVA response, whereas Aflibercept treatment (p = 0.017, OR = 1.107, 95% CI = 0.220,2.051) compared with other drugs and a positive “early functional response” (p < 0.001, OR=-1.393, 95% CI=-1.946,-0.857) were positive predictors. A higher baseline CMT (p < 0.001, OR = 0.019, 95% CI = 0.012,0.0261) and an “early anatomical response”, (p < 0.001, OR=-1.677, 95% CI=-2.456, -0.943) were predictors for greater reduction in CMT. Overall, the variables could predict only 23% of BCVA and 52% of CMT response.ConclusionsThe study shows a significant proportion of DME patients do not respond to anti-VEGF therapy and identifies several clinical predictors for treatment outcomes.Trial registrationThe study was approved through the Human Research Ethics Committee, University of Tasmania (approval number H0012902), and the Southern Adelaide Clinical Human Research Ethics Committee (approval number 86 − 067).
Does seminal fluid bacterial isolate(s) affect in vitro fertilization — embryo transfer outcome?
Authors: Babandi Rukayya Muhammad , Ibraheem Rais Shuaibu , Garba Rayyan Muhammad , Liman Idris Muhammed , Ismail-Are Amina , Samuel Yakubu 
Published: April 2023

Abstract
Background
The chance of achieving a successful pregnancy through in vitro fertilization and embryo transfer (IVF-ET) is limited despite recent scientific advances in this field due to several factors that are known to affect the outcome. There are studies linking the presence of bacteria in the male genital tract to poor semen parameters and IVF-ET outcomes. Results are, however, contradictory. The finding of confirmed genital tract infection warrants treatment, especially when dealing with infertile couples, but treating asymptomatic bacteriospermia is controversial. This study assessed the prevalence and effects of seminal fluid bacterial isolates on semen quality and rates of fertilization and biochemical and clinical pregnancies in IVF-ET.

Methodology
This is an analytical cross-sectional study conducted at the IVF Center of National Hospital Abuja, Nigeria. Due to the low turnout of clients, we enrolled all consecutive consenting eligible male partners of women undergoing the procedure during the study period to obtain a sample size of 242. Participants observed sterile techniques to prevent contamination of the seminal fluid during collection. Growth of bacteria > 10,000 colony-forming units (CFU)/ml was considered significant and tested for sensitivity to a panel of antibiotics. We determined the influence of positive bacterial isolates on fertilization, biochemical pregnancy, clinical pregnancy (primary outcome), and multiple pregnancies. Data were analyzed using SPSS version 22. Student’s t-test, chi-square test, and Fisher’s exact tests were employed as appropriate. p-value < 0.05 at a 95% confidence interval was regarded as statistically significant.

Results
Seminal fluid culture was positive in 57 patients (47.11%). Staphylococcus aureus was the predominant organism cultured (43.90%), followed by Streptococci spp. (21.05%), Escherichia coli (17.54%), Klebsiella spp. (8.77%), Pseudomonas aeruginosa (5.26%), Staphylococcus saprophyticus (1.75%), mixed Staphylococcus aureus, and Streptococcus spp. organisms (1.75%). The fertilization rate was 95.4%, the biochemical pregnancy rate was 42.2%, the clinical pregnancy rate was 38%, and the multiple pregnancy rate was 16.53%. Significant factors found to be associated with positive clinical pregnancy were primary infertility (p-value = 0.001) and negative seminal fluid culture result (p-value = 0.033).

Conclusion
The prevalence of bacteriospermia was relatively high, and the presence of bacterial isolates adversely affected fertilization and clinical pregnancy rates among couples undergoing the IVF-ET program.
Prospects of potential adipokines as therapeutic agents in obesity-linked atherogenic dyslipidemia and insulin resistance
Authors: Roy Probin Kr , Islam Johirul , Lalhlenmawia Hauzel 
Published: April 2023

Abstract
Background
In normal circumstances, AT secretes anti-inflammatory adipokines (AAKs) which regulates lipid metabolism, insulin sensitivity, vascular hemostasis, and angiogenesis. However, during obesity AT dysfunction occurs and leads to microvascular imbalance and secretes several pro-inflammatory adipokines (PAKs), thereby favoring atherogenic dyslipidemia and insulin resistance. Literature suggests decreased levels of circulating AAKs and increased levels of PAKs in obesity-linked disorders. Importantly, AAKs have been reported to play a vital role in obesity-linked metabolic disorders mainly insulin resistance, type-2 diabetes mellitus and coronary heart diseases. Interestingly, AAKs counteract the microvascular imbalance in AT and exert cardioprotection via several signaling pathways such as PI3-AKT/PKB pathway. Although literature reviews have presented a number of investigations detailing specific pathways involved in obesity-linked disorders, literature concerning AT dysfunction and AAKs remains sketchy. In view of the above, in the present contribution an effort has been made to provide an insight on the AT dysfunction and role of AAKs in modulating the obesity and obesity-linked atherogenesis and insulin resistance.

Main body
“Obesity-linked insulin resistance”, “obesity-linked cardiometabolic disease”, “anti-inflammatory adipokines”, “pro-inflammatory adipokines”, “adipose tissue dysfunction” and “obesity-linked microvascular dysfunction” are the keywords used for searching article. Google scholar, Google, Pubmed and Scopus were used as search engines for the articles.

Conclusions
This review offers an overview on the pathophysiology of obesity, management of obesity-linked disorders, and areas in need of attention such as novel therapeutic adipokines and their possible future perspectives as therapeutic agents.

Graphical Abstract