#6658 ORAL HEALTH STATUS IN DIABETIC AND NON-DIABETIC PATIENTS ON MAINTENANCE HEMODIALYSIS TREATMENT
Authors: Rambabova Emilija , Bushljetik Irena Rambabova- , Trajcheska Lada , Markovska Zhaklina Shterjova- , Krecova Vasiliki , Gjorgjievska Gordana , Spasovska Mirjana Popovska , Carcev Mile 
Published: June 2023

Abstract

Background and Aims
Uremic toxins and inflammation influence the oral health in patients on maintenance hemodialysis treatment. The presence of diabetes additionally aggravates the oral status. Aims: To compare the oral health status in diabetic and non-diabetic patients on different dialysis modality treatment.

Method
Observational, cross-section, monocentric study was conducted in 72 hemodialysis (HD) patients divided into two groups regarding the presence of Diabetes mellitus (DM). Patients were routinely designed to hemodialysis or hemodiafiltration (HDF) during the previous year of HD treatment. Demographic characteristics as patients age, dialysis vintage, laboratory inflammatory markers as C-reactive protein (CRP), albumin and Interleukin 6 (IL-6) were measured at the start of the study. Also, uremic small and middle molecules as blood urea nitrogen (BUN), creatinine, β2-microglobilin (β2M), myoglobin, albumin, free light chains kappa (FLC-k), and free light chains lambda (FLC-λ) were analyzed. Patients were examined by a dentist specialist scoring the oral hygiene index (OHI) by Greene Vermillion as good, fair and poor. Presence of tooth fillings and extractions, caries, hyperkeratosis, periodontal disease, erosions, ulceration, erythema, pigmentations, saburral tonque and uremic fetor were notified. Gingival hyperplasia (GH) was scored (1-3) with 3 for worst score and the tooth color was scored 1-3, signing 1-yellow, 2-gray, 3-white. Data was presented as mean and standard deviation for continuous and percentages for nominal values. X squared Fisher exact and Mann-Whitney test were used for statistical analysis. P&lt;0.05 was considered as significant.

Results
The patients from group 1 - with DM (N=26) didn't differ from the non-diabetic group (N= 46) in respect of gender, age and dialysis modality but had significantly shorter dialysis vintage (48.68 ± 37.45 vs. 88.13 ± 63.29, P = .02, respectively). From the inflammatory markers only Il-6 was significantly higher in diabetics (P = .03). All the analyzed uremic toxins – small and middle molecules also didn't differ between the two groups. Diabetic patients were at 3 fold risk for manifestation of fissure, 4 fold risk for pigmentations and 7 fold risk for erythema (OR 3.58; CI:1.017-12.380, p= 0.003; OR 4.12; CI:0.684-22.870; p= 0.02, OR 4.84; CI:1.343-17.498, p= 0.000), (OR 7.25; CI:1.123-46.880, p= 0.000), respectively. GH was more likely to be present in diabetic patients (35%, 54%, 11% vs 83%, 15, 0%, p= 0.000, respectively). The presence of hyperkeratosis, periodontal disease erosions, caries, extractions, tooth fillings and the tooth colour didn't differ between the groups. Diabetics were found with higher percentage of bad oral hygiene index (38% vs 20%), but the overall comparison of OHI showed no significant difference.

Conclusion
Oral health is significantly deteriorated in dialysis patients, especially in those with inflammation. Diabetic patients are at higher risk of developing changes in the oral health status.