bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation analysis of HIF-1α and Ca15-3 in response to neoadjuvant chemotherapy in locally advanced breast cancer: A cohort study in Indonesia
Authors: Manginstar Christian , Oley Mendy Hatibie , Oley Maximillian Christian , Merung Marselus , Langi Fima Lanra Fredrik G. , Kepel Billy Johnson , Rusli Lie Venny , Islam Andi Asadul , Faruk Muhammad 
Published: January 2023

BACKGROUND: Breast cancer (BC) is the most common cancer among women worldwide and a leading cause of death in Indonesia. The primary treatment of locally advanced BC is neoadjuvant chemotherapy (NAC). The rapid proliferation of tumor cells in a neoplastic microenvironment is largely due to hypoxia, which also encourages the development of chemoresistant BC. The master regulator of the hypoxia response is hypoxia-inducible factor-1α (HIF-1α). The response evaluation criteria in solid tumors (RECIST) is an objective response metric that demonstrates the efficacy of a NAC based mostly on the size of the tumor. Ca15-3 is the protein product of the MUC1 gene and is the most widely used serum marker in BC. The purpose of this study is to investigate the relationship between HIF-1α and RECIST and between Ca15-3 and RECIST and to assess the relationship among all of them in BC. METHODS: This observational study used the prospective cohort method included 11 patients with histopathologically confirmed BC, specifically invasive ductal carcinoma. We evaluated the changes in HIF-1α and Ca15-3 serum levels using ELISA and measured tumor lesions with RECIST. The procedure was carried out twice. Serum levels were measured at baseline, and after receiving two cycles of NAC (5 weeks). RESULTS: Among the 11 patients included in this study, HIF-1α, Ca15-3, and RECIST decreased significantly after NAC. The changes in RECIST correlated with Ca15-3: each unit decrease in RECIST score was associated with a 0.3-unit decrease in Ca15-3 levels (p = 0.019). CONCLUSIONS: There was a decrease in HIF-1α, followed by a decrease in Ca15-3 and RECIST in response to chemotherapy. There was a statistically significant correlation between Ca15-3 and response to chemotherapy. This study evidences the relationship between factors that shape the local tumor microenvironment.
Authors: Pujiastuti Maria , Sinurat Samfriati , Citra Halawa Mistari Agnes 
Published: January 2023

INTRODUCTION: Final year students will confront different assignments and obstacles each semester. The final task in preparing the thesis experienced by students becomes a burden that is quite energy-consuming, time that triggers students to become depressed individuals which can cause stress. Stress that cannot be managed properly has a harmful impact on the mental and physical health of students. One way that is easily accessible is by doing yoga. Yoga is a physical exercise that can have a positive effect on health and can reduce stress. The purpose of this study is to determine the effect of yoga exercise on reducing stres levels in final year students in writing a thesis. Method: This research method uses a one-group pre-post test design. The population in this study are 113 respondents. The sampling technique is non-probability sampling with simple random sampling with a total of 32 respondents. Data analysis with Wilcoxon sign rank test. Result: The results of the study obtained p-value = 0.000 (p <0.05) so it can be concluded that there is an effect of yoga exercise on reducing stress levels in final year students in writing thesis. Discussion: Yoga exercise can increase parasympathetic activity and increase GABA (Gamma Aminobutyric Acid). In a relaxed or meditative body and mind condition, it can reduce negative emotions, reduce feelings, and increase calm in individuals so as to reduce anxiety experienced.

Keywords: Yoga Exercise, Stress Level, Final Year Students
HELAH DAN HYBRID CONTRACTS (al-’UKUD al-MURAKKABAH) PADA PRODUK KEUANGAN SYARI’AH PERSPEKTIF FIQH MUAMALAH
Authors: Mursal Mursal , Bustami Yuserizal 
Published: January 2023

Seiring pesatnya kemajuan zaman, lembaga keuangan syariah harus bisa memenuhi kebutuhan bisnis modern dengan menyajikan produk-produk inovatif dan lebih variatif serta sesuai syariah. Tantangan ini menuntut para praktisi, regulator, konsultan, dewan syari‟ah dan akademisi bidang Ekonomi Islam untuk kreatif merespon perkembangan tersebut. Solusi yang diberikan ialah dengan penggabungan beberapa akad (multi akad/hybrid contracts). Akad dalam lembaga keuangan syariah tidak lagi sesederhana seperti yang ada dalam kitab fiqh klasik tapi bertransformasi menjadi akad-akad hybrid dan bertingkat-tingkat. Oleh karena akad-akad muamalah sederhana/klasik tersebut pada dasarnya bukan akad yang dapat diterapkan dalam sistem keuangan modern maka diperlukan upaya-upaya untuk mentransformasikan akad-akad tersebut sehingga aplikatif dalam sistem keuangan Islam. Yang menjadi permasalahan dalam penelitian ini adalah apa saja produk lembaga keuangan syariah yang menggunakan helah dan hybrid conracts (al-‟ukud al-murakkabah) dan Bagaimanakah perspektif fiqh mauamalah mengenai helah dan hybrid conracts (al‟ukud al-murakkabah). Inovasi pengembangan produ ksyariah melalui FATWA DSN MUI hybrid contract smerupakan keniscayaan untuk memenuhi kebutuhan akan produk transaksi di bidang keuangan syari‟ah, hybrid contracts yang ada pada produ kkeuangan syariah mendapat legitimasi dari FATWA DSN MUI. Namun ada beberapa dalil yang secara khusus menerangkan tentang penggabungan beberapa akad dalam beberapa konteks saja seperti menggabungkan jualbeli dengan jualbeli (bay al-‟inah), bay dengan qarddan lain sebagainya. Dari beberapa produk keuangan syariah ada sebagian hybrid contracts yang bertentangan dengan nash dan lebih identik kepada helah ziyadahribawi, sepertiga dari ema smenggunakan akad rahndanijarah, talangan haji menggunkan akad qarddanijarah, dan di pasar komudita ssyariah lebih menyerupai bay al-„inahataupuntawaruqmunazom yang menjadi helahribawi.
UPAYA MENINGKATKAN KEMAMPUAN GURU DALAM MENYUSUN LAPORAN HASIL BELAJAR MELALUI PROGRAM IN HOUSE TRAINING DI SMP NEGERI 11 MUARA TEWEH TAHUN PELAJARAN 2021/2022
Authors: Hasbi Rijali 
Published: January 2023

Realita yang terjadi di SMP Negeri 11 Muara Teweh adalah Kemampuan guru dalam mengelola laporan hasil belajar secara elektronik masih rendah, dengan ditunjukkan data bahwa kemampuan guru dalam mengelola laporan hasil belajar secara elektronik masih rendah, guru masih gaptek dengan penggunaan TIK atau belum bisa menyusun laporan hasil belajar secara elektronik, program In House Training belum pernah di lakukan di SMP Negeri 11 Muara Teweh. Oleh karenanya peneliti yang sekaligus sebagai kepala sekolah hendak meningkatkan Kemampuan guru dalam mengelola laporan hasil belajar secara elektronik melalui program In House Training. Teknik pengumpulan data pada penelitian ini menggunakan teknik non tes. Teknik nontes merupakan teknik pengumpulan data yang tidak baku dan hasil rekayasa dari guru dan sekolah. Berdasarkan penilaian Kemampuan guru dalam menyusun laporan hasil belajar pada siklus I dapat diketahui bahwa Kemampuan guru dalam menyusun laporan hasil belajar dalam kategori baik., maka dapat diketahui bahwa Kemampuan guru dalam menyusun laporan hasil belajar semakin meningkat, terdapat peningkatan Kemampuan guru dalam menyusun laporan hasil belajar yang dilihat dari penilaian rata-rata Kemampuan guru dalam menyusun laporan hasil belajar semula pada kondisi pra siklus menunjukkan rata-rata penilaian yang cukup baik meningkat menjadi baik. Meskipun demikian peningkatan Kemampuan guru pada siklus I belum mampu mencapai target yang ditetapkan yaitu 100%. Berdasarkan penilaian Kemampuan guru dalam menyusun laporan hasil belajar pada siklus II diketahui bahwa skor rata-rata menunjukkan nilai 5,37 dalam kategori sangat baik. Dengan demikian dapat diketahui bahwa Kemampuan guru dalam menyusun laporan hasil belajar yang ada di SMP Negeri 11 Muara Teweh sudah sangat baik.
Towards Gender Equality in Hungarian Universities
Authors: Abusalha Sirin 
Published: January 2023

Women's participation in higher positions in education, particularly in higher education, is a critical issue. Governments are working toward improving gender equality in education, as well as other aspects of the issue such as economics, social issues, and work. This study aims to investigate the factors that influence gender equality at the Budapest University of Technology and Economics. To accomplish the aim, two research questions were set up: How do the employees perceive gender equality at BME, and what factors have an impact on gender equality? Plus, what does the BME Gender Equality Plan reveal about workplace equality and policies, and how is the university working towards achieving gender equality?The study relied on qualitative methods, such as interviews and data analysis of the gender equality plan 2022-2025 and its intervention areas. The study explored the university background and experiences toward achieving gender equality, and the challenges encountered. The interviews revealed some of the challenges that the participants have faced regarding equal pay, promotion, and research opportunities. The evidence indicates that there is an underrepresentation of women in managerial and teaching positions, while there is an overrepresentation in administration positions. This can be attributed to the lack of formal policies that aim to promote gender equality, culture, and the lack of appropriate communication channels. However, based on the Gender Equality Plan 2022-2025, the university aims towards achieving gender equality within all faculties.
СПОРІДНЕНА ПРАЦЯ ЯК СКЛАДОВА ОСВІТНЬОЇ ПОЛІТИКИ ІНФОРМАЦІЙНОГО СУСПІЛЬСТВА
Authors: Букач Микола 
Published: January 2023

Стаття присвячена реалізації освітніх ідей українського філософа Г. С. Сковороди в умовах інформаційного суспільства. Автор звертає увагу на одну із провідних освітніх ідей філософа, зокрема, споріднену працю, яка в умовах новітніх технологій розкриває перспективні напрямки для розвитку освіти. Виклики інформаційного суспільства щодо освітньої сфери, які пов’язані із суттєвим збільшенням надходження обсягів інформації, призвели до фундаментальних змін, як у роботі вчителя, так і в навчанні дитини.
Технологізація розумової діяльності, відкриваючи нові шляхи до інноваційного творчого мислення, розширення можливостей самостійного пошуку та засвоєння знань, разом з тим стала причиною підвищення запиту на якісні освітні послуги, що вплинуло на потребу у переосмисленні підготовки педагогічних кадрів.
Наголошується на необхідності розглядати освіту як особливу галузь, як для становлення країни, так і для особистісного розвитку людини. Виходячи з цього, питання спорідненої праці пропонується розглядати вже починаючи з етапу підготовки майбутніх вчителів, і через них, як носіїв якісної освіти, запроваджувати споріднену працю до безпосередньої роботи з дитиною.
Споріднена праця розглядається не лише як можливість вирішення проблеми підвищення якості педагогічних кадрів, але й як основа формування творчої особистості вчителя. У статті наголошується про необхідність дбайливого зрощування спорідненого до педагогічної діяльності майбутнього вчителя, через більш ефективне поєднанням теоретичного і практичного навчання, через систему професійно-спрямованих педагогічних практик, щоб студент з перших курсів мав змогу відчути, що він займається власне спорідненою справою.
У статті піднімається питання щодо пошуку талантів кожної дитини і створенню умови для їх подальшого розвитку, що є суттєвою відмінністю від тих підходів, які розглядалися на попередніх етапах становлення освітньої системи.
У дослідженні були використані теоретичні методи аналізу, синтезу, аналогії, а також емпіричні методи спостереження та вивчення продуктів діяльності. Отримані результати вказують на необхідність більш ретельного розгляду проблеми.
The role of left ventricle global longitudinal srain in prediction of chemotherapy — induced cardiotoxicity in breast cancer patients treated by low and moderate cumulative doses of anthracyclines
Authors: Levina V. D. , Poltavskaya M. G. , Sedov V. P. , Chomakhidze P. Sh. , Bolotina L. V. , Deshkina T. I. , Kuklina M. D. , Meshcheryakov A. A. , Komarova A. G. , Kuli-Zade Z. A. , Gerasimov A. N. 
Published: January 2023

Objective. To evaluate the alterations of Global longitudinsl strain (GLS) and it’s value for prediction of cardiotoxicity of low to moderate cumulative doses of anthracyclines. Methods. Forty-nine women 50 ± 10 years old with breast cancer, treated with anthracyclines (cumulative dose of 251 ± 60 mg/m2) were enrolled in the study. Echocardiography with GLS measurement was performed at baseline, at the end of anthracycline treatment, then every 3 months during 1 year. Cardiotoxicity was defined as a decline in left ventricular ejection fraction (LVEF) of at least 10 % to ≤ 53 %. Results. There was a significant increase in mean LVESV and LVEDV and decrease of GLS (р < 0,05) but not LVEF at 3 month post anthracycline treatment. Cardiotoxicity was detected in 8 patients (16 %) with moderate baseline risk. Absolute ≥ 4 % reduction of GLS during follow-up, GLS andpercent of it’s reduction from baseline to 3 month post-anthracycline were predictive of cardiotoxicity (AUC = 0,822 and 0,870, respectively). The reduction in GLS of >12,5 % from baseline at 3 month post anthracyclines was predictive of cardiotoxicity with sensitivity of 80 % and specificity of 95 %. Conclusions. GLS and its reduction from baseline has shown predictive value for development of cardiotoxicity in patients with moderate risk treated with low-to moderate cumulative doses of antracyclines. Additional echocardiography with GLS assessment at 3–6 month after completion of anthracycline treatment may be recommended irrespective of cardiotoxicity risk.
Could we use digital infrared medical thermography to distinguish SARS-СоV-2 viral from community acquired pneumonia?
Authors: Karamyshev Y. V. , Dolgov I. M. , Zheleznyak I. S. , Lepekhin I. V. , Makhnovsky A. I. 
Published: January 2023

Objectives: This study set out to determine the possibility to differ SARS-СоV-2 viral pneumonia from community acquired pneumonia (CAP) by mean of digital infrared medical thermography. Material, methods: Totally 380 patients were evaluated: with diagnosis 'U07.1COVID-19, virus identified. SARS-CoV-2 pneumonia' (group 1) — 208 pts, with community acquired viral or bacterial pneumonia (group 2) — 172 pts. Thermographic assessment was performed using TBC300-med infrared camera (manufactured by LLC 'STC SILAR', Saint Petersburg, Russia, image format 384 x 288, thermal resolution 30 mK). To store and analyze thermographic images cloud application 'TVision' (LLC 'Dignosys', Russia) was used. Quadrangle in shape regions of interest (ROI) were automatically created on the front and back of the thorax roughly in the projection of the upper lobe (ULP) and the lower lobe (LLP) of the lungs. Mean temperature was measured and thermal gradients- ΔТ° (side-to-side temperature difference) - were calculated between symmetric ROI both on front and back of the thorax. Values obtained were taken as modulus, the greatest value used for analysis. Results: Mean ΔТ° value were significantly higher in SARS-CoV-2 pneumonia compared with CAP group (0,56 ± 0,35 ºC and 0,32 ± 0,14ºC respectively; P < 0,05). The ΔТ° value > 0,51 °C is associated with SARS-CoV-2 pneumonia with sensitivity 71 % and specificity 62,8 %, area under the ROC curve 0.739; P < 0,05). Conclusions. Infrared thermography proved to be a sensitive method for detection of temperature differences between both types of pneumonia and may contribute to preliminary diagnosis.
Investigation of microorganisms in cannabis after heating in a commercial vaporizer
Authors: Sopovski Danielle S. , Han Jing , Stevens-Riley Marla , Wang Qiang , Erickson Bruce D. , Oktem Berk , Vanlandingham Michelle , Taylor Cassandra L. , Foley Steven L. 
Published: January 2023

IntroductionThere are concerns about microorganisms present on cannabis materials used in clinical settings by individuals whose health status is already compromised and are likely more susceptible to opportunistic infections from microbial populations present on the materials. Most concerning is administration by inhalation where cannabis plant material is heated in a vaporizer, aerosolized, and inhaled to receive the bioactive ingredients. Heating to high temperatures is known to kill microorganisms including bacteria and fungi; however, microbial death is dependent upon exposure time and temperature. It is unknown whether the heating of cannabis at temperatures and times designated by a commercial vaporizer utilized in clinical settings will significantly decrease the microbial loads in cannabis plant material.MethodsTo assess this question, bulk cannabis plant material supplied by National Institute on Drug Abuse (NIDA) was used to assess the impact of heating by a commercial vaporizer. Initial method development studies using a cannabis placebo spiked with Escherichia coli were performed to optimize culture and recovery parameters. Subsequent studies were carried out using the cannabis placebo, low delta-9 tetrahydrocannabinol (THC) potency and high THC potency cannabis materials exposed to either no heat or heating for 30 or 70 seconds at 190°C. Phosphate-buffered saline was added to the samples and the samples agitated to suspend the microorganism. Microbial growth after no heat or heating was evaluated by plating on growth media and determining the total aerobic microbial counts and total yeast and mold counts.Results and discussionOverall, while there were trends of reductions in microbial counts with heating, these reductions were not statistically significant, indicating that heating using standard vaporization parameters of 70 seconds at 190°C may not eliminate the existing microbial bioburden, including any opportunistic pathogens. When cultured organisms were identified by DNA sequence analyses, several fungal and bacterial taxa were detected in the different products that have been associated with opportunistic infections or allergic reactions including Enterobacteriaceae, Staphylococcus, Pseudomonas, and Aspergillus.
Epidemiology, antimicrobial resistance, and mortality risk factors of carbapenem resistant gram-negative bacteria in hematopoietic stem cell transplantation recipients
Authors: Jia Yan , Li Yun , Liu Yi , Yang Ziyue , Chen Xuefeng , Liu Yanfeng 
Published: January 2023

IntroductionCarbapenem resistant gram-negative bacteria (CRGNB) infection is more and more frequent in patients after hematopoietic stem cell transplantation (HSCT), and the prognosis is very poor. The purpose of this study was to investigate the clinical characteristics and risk factors for mortality with CRGNB infection in HSCT recipients, and to provide useful information for guiding the application of antibiotics and improving the prognosis in the future.MethodsElectronic medical records of CRGNB infected patients who underwent HSCT in Xiangya Hospital from January 1, 2015 to June 30, 2022 were collected. At the same time, 1:1 case-control matching was performed according to gender, age and disease type. The epidemiological characteristics and drug resistance of patients with CRGNB infection and non-CRGNB infection were compared. Logistic regression and Cox regression analysis were used to determine the risk factors for CRGNB acquisition and death respectively, and a prediction model of overall survival was constructed by R language.Results and DiscussionThe crude infection rate of CRGNB in HSCT recipients was 7.42%, and the mortality rate was 47.1%. CRGNB was resistant to most commonly used antibiotics. Time interval from diagnosis to transplantation &gt;180 days (HR=7.886, 95% CI 2.624-23.703, P=0.000), septic shock (HR=6.182, 95% CI 2.605-14.671, P=0.000), platelet count &lt; 20 × 109/L (HR=2.615, 95% CI 1.152-5.934, P=0.022) and total bilirubin &gt; 34.2 μmol/L (HR=7.348, 95% CI 2.966-18.202, P=0.000) at the initial stage of infection were 4 independent risk factors associated with mortality. CRGNB infection has become a serious threat to HSCT recipients. Clinicians should pay high attention to it and actively seek personalized treatment strategies suitable for local medical conditions.
Effects of sacubitril/valsartan on cardiac reverse remodeling and cardiac resynchronization in patients with acute myocardial infarction
Authors: Yang Pei , Li Xiaokang , Wang Lijin , Wu Xinlei , Wang Chiyao , Li Tian , Wang Haiyan 
Published: January 2023

IntroductionIn 2014, the PARADIGM-HF trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) has shown that sacubitril/valsartan can reduce the risk of hospitalization and death from cardiovascular causes more effectively than enalapril (an ACEI) in heart failure patients with reduced ejection fraction (HFrEF). Similarly, the PARADIGM-HF trial (Comparison of Sacubitril-Valsartan vs. Enalapril on Effect on NT-proBNP in Patients Stabilized from an Acute Heart Failure Episode) came to similar conclusions and extended the PARADIGM-HF trial results in 2019. Since then, numerous new studies have provided further insight in HFrEF, sacubitril/valsartan can reduce N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, increase left ventricular ejection fraction (LVEF), reverse ventricular remodeling, and reduce other non-fatal manifestations of clinical deterioration as compared to ACEI/ARB. However, few trials have compared the effects of these drugs in patients shortly after AMI. Therefore, it is necessary to further explore the clinical efficacy and safety of sacubitril/valsartan vs. valsartan in patients with AMI.MethodsWe conducted an open-label, prospective, randomized controlled trial to determine the superiority in ameliorating ventricular remodeling and preventing of heart failure in patients with AMI after percutaneous coronary intervention (PCI), 148 patients were randomly assigned (85 to sacubitril/valsartan and 63 to valsartan).ResultsLAV, LVDV, and LVSV were all decreased in the sacubitril/valsartan group when compared with before treatment, but there was no difference between the sacubitril/valsartan group and the valsartan group. In addition, compared with before treatment in the sacubitril/valsartan group, the heart global work index (GWI) and the global work efficiency (GWE) increased, while the heart global wasted work (GWW) decreased. Patients in the sacubitril/valsartan group have similar MACE and adverse side effects to those in the valsartan group.ConclusionSacubitril/valsartan has the same performance as valsartan in inhibiting ventricular remodeling and preventing heart failure after PCI in patients with AMI, and its clinical application is safe. It provides a clinical foundation for the application of sacubitril/valsartan in patients with AMI.