bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between oxidative balance score and gallstone disease: a population-based study from NHANES
Authors: Zhang Mengmeng , Yang Aiming 
Published: January 2025

BackgroundOxidative stress has been reported to participant in the pathogenesis of gallstones. Oxidative balance score (OBS) represents pro-oxidant and antioxidant exposures to diet and lifestyle, closely associated with multiple metabolic disorders. However, the relationship between OBS and gallstones remains unclear.MethodsThis study analyzed cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 2017–2020. OBS was calculated based on the 24-h recall interviews or questionnaires. We used weighted logistic regression, restricted cubic splines (RCS), weighted quantile sum (WQS) regression and the Bayesian kernel machine regression (BKMR) model to identify the relationship between OBS and gallstones. Subgroup analysis and sensitivity analysis were used to explore potential heterogeneity and stability of the results. Mediation analysis was performed to assess the mediating effects of serum lipid in the association between OBS and gallstones.ResultsA total of 7,618 participants were finally included in this study. Weighted logistics regression showed that total OBS was associated with gallstones risk (OR = 0.98, p = 0.03), particularly in individuals who were under 60 years old, Hispanic, educated below high school, non-smokers, had hypertension or malignancy. Dietary and lifestyle OBS independently contribute to the protection against gallstones. RCS analysis indicated a non-linear relationship between OBS and gallstones (p = 0.03). WQS and BKMR model identified that BMI, vitamin E, vitamin B6, magnesium and carotene played relatively important role among 20 components. Mediation analysis showed serum TG and HDL as mediators of the association between OBS and gallstones.ConclusionHigher OBS or increased oxidative balance are positively associated with reduction of gallstone risk. This findings provide valuable insights for surveillance and interventions targeting for antioxidant-rich diet and lifestyle for gallstone disease.
Current practices and key challenges associated with the adoption of resilient, circular, and sustainable food supply chain for smallholder farmers to mitigate food loss
Authors: Vásquez Neyra Jessika Milagros , Cequea Mirza Marvel , Schmitt Valentina Gomes Haensel 
Published: January 2025

IntroductionIn response to increasing global food insecurity, resilient, circular, and sustainable practices hold significant potential to enhance food supply chain performance and reduce food loss. This study examines the current practices and key challenges faced by Peruvian smallholder farmers in managing a resilient, circular, and sustainable food supply chain, proposing a hybrid model that integrates ancestral agricultural knowledge with modern innovations.MethodsUsing a qualitative approach, in-depth interviews were conducted with 16 smallholder farmers from various regions of Peru. Participants were selected through purposive sampling, focusing on farmers who apply organic agricultural techniques. Data were analyzed using content analysis techniques supported by ATLAS.ti 23 software to identify patterns in practices and challenges.ResultsThe findings reveal that farmers operate within short supply chains, without intermediaries, applying intuitive practices aligned with circular economy principles, including Rethink, Redesign, Reduce, Replace, Reuse, Repurpose, and Recycle, but excluding Recovery. While social and economic dimensions are prioritized, current practices are insufficient to ensure long-term sustainability. Key challenges include technological limitations, restricted market access, and low consumer awareness.DiscussionA hybrid model is proposed, combining resource-efficient technologies with culturally rooted practices, fostering multi-stakeholder collaboration. This approach addresses identified gaps and contributes to food security, environmental sustainability, and the achievement of Sustainable Development Goals 1 (No Poverty), 2 (Zero Hunger), and 12 (Responsible Consumption and Production).
THE INFLUENCE OF POSTPARTUM EXERCISE ON LEVEL OF AFTERPAINS IN POSTPARTUM WOMEN
Authors: Lufianti Anita , Masrinia Fatimah  , Mika Agustiana  
Published: January 2025

Introduction: Postpartum period is the period after childbirth up to 6 weeks or 42 days, during the postpartum period, the reproductive organs slowly undergo changes, namely uterine involution, which can cause post-partum pain. Postpartum exercise is a form of early ambulation for postpartum women aimed at facilitating the involution process. Objective: The purpose of the research is to investigate the influence of postpartum exercise on the level of afterpains. Method: This research using the 'quasi-experimental' method, with a one-group pretest-posttest-design approach. The sample used in this study was 10 respondents at the Permata Bunda Hospital. The sample were taken by purposive sampling The collecting data tool used a standard of operational procedure chcek list of post-partum exercise and observation sheet on pain. Data analysis using paired samples t-test. Result: The result showed the majority of post-partum mother’s pain decreased from moderate pain to mild pain 8 (80%), from severe pain to moderate pain 2 (20 %). There is an effect of postpartum exercises on the level of afterpains in postpartum women p-value of 0.00> 0.05. Conclusion: The results of the respondent's pain level after being given postpartum exercise during the posttest the pain level decreased.
Elective Stories
Authors: Pinder Heather 
Published: January 2025

For my senior elective, I wanted to go abroad and experience medicine in a completely different setting than the UK. As I am interested in orthopaedics, this led to me applying for an elective at the University of Stellenbosch in South Africa. I had heard wonderful things from previous SSC and Elective supervisors about the fantastic experience in South Africa, after a bit of research I decided that Tygerberg Hospital in Cape Town seemed like the ideal destination.
I also had other more personal motivations for pursuing an elective in South Africa, as Cape Town holds a very special place in my own family history. During the Second World War, my Great-Grandfather was posted to Cape Town with the Fleet Air Arm as an aircraft engineer. Here, he met and married my Great-Grandmother, originally from Muizenberg (A beachside town to the south of Cape Town). Before my trip I was able to do extensive ancestral research and was able to visit some of the areas where she grew up and lived, allowing me to experience the culture she left behind in 1944.
Entering Tygerberg Hospital for the first time was very daunting. The hospital campus is the size of a small village and is the second largest hospital in South Africa - with 1899 beds. I was welcomed to the department with the 7:30 trauma meeting, where all the orthopaedic trauma patients admitted in the last day were discussed, and a surgical plan was formed for each.
The 24hr emergency theatre list from the day and night before was also discussed, with the registrars presenting each case to the team of consultants. After this I would head to theatres, finding a different list to scrub in with every day.
I was also able to shadow one of the registrars during their 24hr call shifts. Due to the high volume of trauma presenting to the hospital, there is an emergency orthopaedic theatre that runs 24/7, where surgeons can work through the backlog of trauma built up from the previous day. Outwith the hospital I had time to explore Cape Town as a city. Cape Town is a beautiful city with a vibrant cultural scene. There are regular tours to Robbin Island, a poignant activity that I feel is crucial in understanding the Apartheid era and inequality faced by so many South African Citizens. I would also thoroughly recommend a walk down Kloof Street, and a venture on the Table Mountain Cable Car, as well as surfing on Muizenberg Beach. Also, a trip to Cape Town is not complete without visiting the African penguin colony on Boulders Beach! The Western Cape is famous for its winemaking, and there were plenty of opportunities to explore the beautiful vineyards on the Franschhoek Wine Tram.
O impacto da comunicação interdisciplinar na segurança do paciente em Unidades de Terapia Intensiva (UTIs)
Authors: Barros Sarah Silva Costa , Costa Fabio da Silva , Coelho Francisca dos Santos Maciel dos Anjos Silva , Silva Flaviana Lopes da , Bezerra Luciara da Silva Alves , Veloso Neto Wilson da Costa , Oliveira Thaina Maria Cunha , Gonçalves Denise Rodrigues Chagas , Campos Maria Vitória Garcia , Sene Lídia Oliveira , Mendes Keylane Kelle Pereira , Andrade João Victor Oliveira 
Published: January 2025

Introdução: O cenário das Unidades de Terapia Intensiva (UTIs) caracteriza-se por sua alta complexidade, exigindo decisões rápidas e precisas de forma contínua. Nesse contexto, a comunicação interdisciplinar entre os membros da equipe multiprofissional é fundamental para garantir a segurança do paciente, reduzindo a ocorrência de erros e eventos adversos. Este trabalho visa investigar como a comunicação eficiente entre os profissionais da equipe multidisciplinar impacta a segurança dos pacientes em UTIs. Método: Este estudo trata- se de uma revisão de literatura com abordagem qualitativa e quantitativa. A pesquisa foi realizada em bases científicas como Medline, Lilacs e BDENF, utilizando descritores: “comunicação” “práticas interdisciplinares” “comunicação interdisciplinar” “segurança do paciente” “unidades de terapia intensiva” e na literatura cinzenta. Resultados e Discussão: Espera-se que a comunicação interdisciplinar eficaz contribua significativamente para a redução de eventos adversos e a melhora da qualidade do atendimento. A discussão abordará os principais desafios enfrentados pelas equipes multiprofissionais na UTI e as melhores práticas para aprimorar a comunicação, como o uso de ferramentas padronizadas, treinamentos e reuniões diárias de equipe. Conclusão: A comunicação interdisciplinar é uma estratégia-chave para garantir a segurança do paciente em UTIs. Investir na capacitação e em protocolos que promovam o diálogo entre os profissionais pode melhorar significativamente os desfechos clínicos e a qualidade do cuidado prestado.
Vitiligo: desafios no diagnóstico e abordagens terapêuticas modernas
Authors: Carlos de Bessa e Silva Júnior  , Giovanna Marcusso Fontenla  , Gisele Gorzelanski Rengel  , Lívia Bernucci Cruz  , Dora Aguiar Bavaresco  , Rafaella Souza Guimarães  , Luis Paulo Bastos Lobo  , Gabriela Soares Garcia  , Bianca Rios Sampaio  , Luiz Henrique Santos Siqueira  
Published: January 2025

O vitiligo é uma doença autoimune que causa perda de pigmentação da pele afetando entre 0,5% e 2% da população mundial. Sua fisiopatologia resulta da interação de fatores como predisposição genética, estresse oxidativo, mecanismos imunológicos e influência neurogênica. Este estudo visa identificar, selecionar e sintetizar as evidências científicas mais relevantes sobre o tema . Destarte, a revisão incluiu pesquisas realizadas entre 2020 e 2024, nas seguintes bases de dados acadêmicas: Google Scholar, PubMed, Up to Date e Scielo tendo sido selecionados 10 artigos que analisavam a fisiopatologia, diagnóstico, estratégias de controle e manejo do vitiligo. O diagnóstico é essencialmente clínico, baseado na análise das características das lesões, podendo ser complementado por exames adicionais quando necessário. O tratamento envolve diversas abordagens, como fototerapia, corticosteróides, inibidores de calcineurina, procedimentos cirúrgicos e terapias inovadoras incluindo tratamentos biológicos. Medicamentos novos estão em estudo, porém sua eficácia e o estudo dos efeitos possíveis, principalmente a longo prazo, têm que ser melhores investigados. Além disso, o suporte psicossocial é crucial para garantir uma melhor qualidade de vida reforçando, assim, a importância de uma abordagem multidisciplinar no tratamento. Embora a monoterapia tenha eficácia limitada, a combinação de tratamentos tópicos ou sistêmicos com fototerapia de ultravioleta B de banda estreita é considerada o padrão-ouro para promover a repigmentação da pele.Apesar dos avanços, ainda há necessidade de estudos mais detalhados sobre a eficácia e os efeitos colaterais de novos medicamentos, principalmente no longo prazo. É fundamental que o dermatologista, em colaboração com o paciente, determine a melhor estratégia terapêutica com base no quadro clínico e nas previsões de acesso ao tratamento. O acompanhamento e a abordagem por uma equipe multiprofissional também são importantes.
Methods for Obtaining and Using Succinic Acid in the Food Industry: A Scoping Review
Authors: Babich Olga Olegovna Babich , Kalashnikova Olga Borisovna , Ulrich Elena Viktorovna , Sukhikh Stanislav Alekseevich 
Published: January 2025

Introduction: Succinic acid is the final metabolite of many microorganisms. It has antioxidant, tonic properties, and also takes part in the metabolic processes of a living organism. Its use in food formulations will help expand the range of functional food products aimed at improving metabolism.Purpose: description of methods for obtaining and features of the use of succinic acid in the food industry for the production of functional foods and biologically active food additives.Materials and Methods: Information search was carried out in the databases Scopus, Web of Science, PubMed, RISC for the period from 01/01/1994 to 03/01/2024. Marketing research reports on the use of succinic acid in the food industry for the period 2016-2023 were also analyzed. The review included review and empirical articles that met the selection criteria in English and Russian. This review of the subject field is based on the PRISMA-ScR protocol.Results: Currently, succinic acid is produced by chemical or biotechnological methods. The most common method is the chemical method (paraffin oxidation, catalytic hydrogenation, maleic acid or maleic anhydride). There is also a biotechnological method based on the cultivation of microorganisms that produce succinic acid. Various organic substrates, including food industry waste, can be used to cultivate microorganisms. It has been shown that succinic acid is included in the list of safe food additives and is used in food production as an acidity regulator. However, due to the fact that it has proven biological effectiveness, succinic acid can be included in the formulations of various food products, thereby providing them with additional functional properties.Conclusion: To introduce the biotechnological method into the real sector of the economy, it is necessary to solve a number of limiting factors. It has been established that succinic acid can be used not only as a traditional food additive (acidity regulator), but also as a dietary supplement. The volumes of production and demand for succinic acid are slowly but increasing, which indicates the need to introduce new technologies for the production of succinic acid in order to meet the demand for this product.
An AIC-type information criterion evaluating theory-based hypotheses for contingency tables
Authors: Altinisik Yasin , Hessels Roy S. , Van Lissa Caspar J. , Kuiper Rebecca M. 
Published: January 2025

Abstract
Researchers face inevitable difficulties when evaluating theory-based hypotheses in the context of contingency tables. Log-linear models are often insufficient to evaluate such hypotheses, as they do not provide enough information on complex relationships between cell probabilities in many real-life applications. These models are usually used to evaluate the relationships between variables using only equality restrictions between model parameters, while specifying theory-based hypotheses often also requires inequality restrictions. Moreover, high-dimensional contingency tables generally contain low cell counts and/or empty cells, complicating parameter estimation in log-linear models. The presence of many parameters in these models also causes difficulties in interpretation when evaluating the hypotheses of interest. This study proposes a method that simplifies evaluating theory-based hypotheses for high-dimensional contingency tables by simultaneously addressing each of the above problems. With this method, theory-based hypotheses, which are specified using equality and/or inequality constraints with respect to (functions of) cell probabilities, are evaluated using an AIC-type information criterion, GORICA. We conduct a simulation study to evaluate the performance of GORICA in the context of contingency tables. Two empirical examples illustrate the use of the method.
La Violencia Sociocultural y su Efecto en la Calidad de Vida del Adulto Mayor: Un Estudio en la Parroquia Santa Rosa
Authors: Coronel Ordóñez Jaime Marcelo , Guzmán Defas Eduardo Efraín , Chango Carrera Jessica Paola , Masaquiza Masaquiza Sergio Gustavo , Moreno Guerra Marco Marcelo 
Published: January 2025

La investigación "Violencia sociocultural y su efecto en la calidad de vida de los/as adultos/as mayores de la parroquia Santa Rosa" analiza el impacto de la violencia sociocultural en esta población vulnerable, destacando sus manifestaciones. En la parroquia Santa Rosa, Cantón Ambato, Ecuador, los adultos mayores enfrentan discriminación por etnia, idioma y vestimenta, además de maltrato físico (30.80%), psicológico (61.50%), patrimonial (53.80%), negligencia (69.20%) y violencia sexual (23.31%). El estudio evalúa la calidad de vida desde dimensiones física, cognitiva, emocional y social, considerando percepciones de familias, comunidad y autoridades. La investigación utiliza un enfoque mixto, es decir combina técnicas cuantitativas y cualitativas, utilizando herramientas como la escala de Barthel, Yesavage y la prueba Mini-Mental. Las entrevistas y encuestas revelan que el 53.80% de las familias y autoridades reconoce la violencia como un problema estructural y cotidiano que afecta profundamente la calidad de vida de los adultos mayores, con consecuencias graves en su bienestar físico, emocional y social. La investigación también confirma que la violencia sociocultural, histórica y prevalente, tiene un impacto multidimensional en los adultos mayores, evidenciando la urgencia de intervenir para mejorar su calidad de vida y transformar las dinámicas sociales en Santa Rosa.
Pendampingan Penyusunan Kurikulum Operasional Madrasah untuk Persiapan Implementasi Kurikulum Merdeka di Madrasah Ibtidaiyah Kabupaten Lamongan
Authors: Nisa Rofiatun , Rohmah Annisa Nidaur , Amar Abu 
Published: January 2025

This assistance aims to provide direct knowledge and practical facilities in preparing the Kurikulum Operasional Madrasah (KOM) and increase knowledge and skills before and after this activity. This service activity was carried out by the service team FAI at Universitas Billfath which was carried out from 27 February to 16 March 2023 with the target of assistance being 3 Madrasah Ibtidaiyah in Karanggeneng District, Lamongan Regency with a total of 18 participants. The stages in this service activity consist of preparation, socialization, mentoring and evaluation. This training activity showed the results of an increase in the participants' understanding and skills regarding the preparation of KOM which is proof that the majority of the training participants successfully understood the overall material provided. Mastery of the training material can be seen from the increase in the pre-test and post-test given, where the average pre-test score was 58 then increased in the post-test to 95. In the aspect of psychomotor skills, the increase can be proven by the success of the participants in compiling the Kurikulum Operasional Madrasah (KOM). each of which will later be used in their Madrasah, and their opinions about this activity show the real benefits of producing a product in the form of a Kurikulum Operasional Madrasah (KOM).
Pengaruh Beban Kerja, Budaya Organisasi, dan Kepuasan Kerja Terhadap Produktivitas Kerja Karyawan yang Bekerja pada Perusahaan Importir Bahan Makanan di Jakarta Barat
Authors: Amrah Husaeni Anissa , Desty Febrian Wenny 
Published: January 2025

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh beban kerja, budaya organisasi, dan kepuasan kerja terhadap produktivitas kerja. Penelitian ini menggunakan metode kuantitatif dengan jumlah populasi sebanyak 678 orang dan dihitung menggunakan rumus slovin sehingga mendapatkan sampel sebanyak 87 orang karyawan yang berkerja pada perusahaan importir bahan makanan dijakarta barat dengan teknik probability sampling, khususnya random sampling. Teknik penarikan data menggunakan kuisioner dalam bentuk G-Form. Yang pengolahan datanya menggunakan software SPSS. Teknik analisis data yang akan di gunakan yaitu regresi linear berganda dengan hasil Y=7,835+(-0,015) (X1)+0,266 (X2)+0,037 (X3), dan uji hipotesis yang terdiri atas uji t dan uji f. Hasil penelitian ini secara parsial menunjukkan: (1) Terdapat pengaruh negatif dan tidak signifikan antara beban kerja terhadap produktivitas kerja yang ditunjukkan dengan nilai thitung<ttabel yaitu -0,431<1,663. (2) Terdapat pengaruh positif dan signifikan antara budaya organisasi terhadap produktivitas kerja yang ditunjukkan dengan nilai thitung>ttabel yaitu 4,586>1,663. (3) Terdapat pengaruh positif dan tidak signifikan antara kepuasan kerja terhadap produktivitas kerja yang ditunjukkan dengan nilai thitung<ttabel yaitu 0,937<1,663. (4) Terdapat pengaruh positif dan signifikan antara beban kerja, budaya organisasi dan kepuasan kerja secara simultan terhadap terhadap produktivitas kerja yang ditunjukkan dengan nilai Fhitung>Ftabel yaitu 10,888>1,663. Koefisien korelasi sebesar (R) sebesar 0,531 yang berarti keeratan antar variabel tidak cukup kuat dan koefisien determinasi sebesar 0,282 yang artinya 28,2% ketiga variabel bebas mempengaruhi kinerja karyawan secara simultan dan sisanya dipengaruhi oleh variabel lain.
How and why should we regulate the metaverse?
Authors: Sitnikov M. S. 
Published: January 2025

The necessity for legal research into the metaverse phenomenon arises due to its considerable economic strength and social capacity. Built on scientific principles and current experience in the metaverse development, this article aims to determine the general outlook for the evolution of legal regulation in the metaverse. The research methodology is based on general methods of scientific knowledge, including analysis, synthesis, systems approach, modeling, and abstraction. The study also employed the following specific scientific methods of legal cognition of reality: formal-legal, historical-legal, comparative, and logical-legal. The distinctive feature of the research consists in its interdisciplinary connection with another branch of knowledge, i.e., political science. As a result, it is shown that the metaverse subject has particularly interested the state, as well as business not only due to the ample opportunities for exploiting the relevant technologies in various areas of life (using public services, educational environment, and others), but also because uncontrolled development of the metaverse can negatively affect public security. The experience of the People’s Republic of China and South Korea holds a special place here. The results of the study enabled the author to identify three possible models of metaverse regulation depending on the level of state control. They are as follows: liberal free (development of the economic component of the metaverse is prioritized), conservative safe (the metaverse sector development should be totally controlled by the state), and mixed (it combines certain key elements of the first two models)..