bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrical Interrogation of Thickness‐Dependent Multiferroic Phase Transitions in the 2D Antiferromagnetic Semiconductor NiI2
Authors: Lebedev Dmitry , Gish Jonathan Tyler , Garvey Ethan Skyler , Stanev Teodor Kosev , Choi Junhwan , Georgopoulos Leonidas , Song Thomas Wei , Park Hong Youl , Watanabe Kenji , Taniguchi Takashi , Stern Nathaniel Patrick , Sangwan Vinod Kumar , Hersam Mark Christopher 
Published: January 2023

Abstract2D magnetic materials hold promise for quantum and spintronic applications. 2D antiferromagnetic materials are of particular interest due to their relative insensitivity to external magnetic fields and higher switching speeds compared to 2D ferromagnets. However, their lack of macroscopic magnetization impedes detection and control of antiferromagnetic order, thus motivating magneto‐electrical measurements for these purposes. Additionally, many 2D magnetic materials are ambient‐reactive and electrically insulating or highly resistive below their magnetic ordering temperatures, which imposes severe constraints on electronic device fabrication and characterization. Herein, these issues are overcome via a fabrication protocol that achieves electrically conductive devices from the ambient‐reactive 2D antiferromagnetic semiconductor NiI2. The resulting gate‐tunable transistors show band‐like electronic transport below the antiferromagnetic and multiferroic transition temperatures of NiI2, revealing a Hall mobility of 15 cm2 V−1 s−1 at 1.7 K. These devices also allow direct electrical probing of the thickness‐dependent multiferroic phase transition temperature of NiI2 from 59 K (bulk) to 28 K (monolayer).
Ultra‐Flexible Giant Magnetoresistance Biosensors for Lab‐on‐a‐Needle Biosensing
Authors: Su Diqing , Wu Kai , Srinivasan Karthik , Nemati Zohreh , Zamani Reza , Chugh Vinit , Saha Renata , Franklin Rhonda , Modiano Jaime , Stadler Bethanie , Wang Jian‐Ping 
Published: January 2023

AbstractFlexible biosensors exhibit great potential for the detection of various biomarkers with the ability to adapt to different surface textures. Here, a lab‐on‐a‐needle biosensing platform based on ultra‐flexible giant magnetoresistance (GMR) biosensors is developed. The fabricated flexible GMR sensors exhibit a MR ratio of 5.2% and a sensitivity of 0.13%/Oe in the linear region, which are comparable to their rigid counterparts. It is found that the magnetic properties of the flexible GMR sensors remain unchanged after 500 cycles of compressive and tensile stress, indicating strong robustness even when applied to a surface that is constantly in motion. The developed platform is then employed for the detection of different concentrations of canine osteosarcoma (OSCA‐8) cells with a limit of detection (LOD) of 200 cells in 20 µL sample (104 cells per mL), which demonstrate the ability to perform real‐time, sensitive, and quantitative cell detection.
Palladium‐Catalyzed Asymmetric [4+3] Cycloadditions of Indene‐2‐carbaldehydes with 4‐Vinylbenzoxazinanones Toward Polycyclic 5H‐Benzo[b]azepines
Authors: Zhang Xiyuan , Gao Yanfeng , Miao Zhiwei 
Published: January 2023

AbstractPalladium‐catalyzed asymmetric [4+3] cycloadditions of indene‐2‐carbaldehydes and 4‐vinyl benzoxazinanones proceeded smoothly in the presence of chiral phosphine ligands to give the corresponding functionalized 5H‐benzo[b]azepines (26 examples, 60% to 89% yield, 88:12 to 95.5:4.5 er) under mild conditions.magnified image
Gene Expression has Distinct Associations with Brain Structure and Function in Major Depressive Disorder
Authors: Liu Shu , Abdellaoui Abdel , Verweij Karin J. H. , van Wingen Guido A. 
Published: January 2023

AbstractMajor depressive disorder (MDD) is associated with structural and functional brain abnormalities. MDD as well as brain anatomy and function are influenced by genetic factors, but the role of gene expression remains unclear. Here, this work investigates how cortical gene expression contributes to structural and functional brain abnormalities in MDD. This work compares the gray matter volume and resting‐state functional measures in a Chinese sample of 848 MDD patients and 749 healthy controls, and these case‐control differences are then associated with cortical variation of gene expression. While whole gene expression is positively associated with structural abnormalities, it is negatively associated with functional abnormalities. This work observes the relationships of expression levels with brain abnormalities for individual genes, and found that transcriptional correlates of brain structure and function show opposite relations with gene dysregulation in postmortem cortical tissue from MDD patients. This work further identifies genes that are positively or negatively related to structural abnormalities as well as functional abnormalities. The MDD‐related genes are enriched for brain tissue, cortical cells, and biological pathways. These findings suggest that distinct genetic mechanisms underlie structural and functional brain abnormalities in MDD, and highlight the importance of cortical gene expression for the development of cortical abnormalities.
Photomodulation on adsorptive desulfurization by Ag(0): Photothermal active sites with high stability
Authors: Li Min , Liu Jun , Tan Peng , Liu Xiao‐Qin , Sun Lin‐Bing 
Published: January 2023

AbstractAg(I) have been applied as active sites to adsorptive desulfurization of transportation fuels. However, its introduction brings the issues of instability and difficulty in desorption. Here, Ag(0) was dispersed in metal‐organic frameworks and used as the photothermal active sites with high stability for desulfurization. Unlike Ag(I), Ag(0) is insensitive to light and can be precisely heated for desorption through surface plasmon resonance. Interestingly, Ag(0) has weak interactions with dibenzothiophene than π‐complexation, but shows the comparable uptake and selectivity to that of Ag(I). The weak adsorbent‐adsorbate interactions fit the photomodulation on desorption where light energy was precisely used to heat the active sites of Ag(0), avoiding heat conduction and loss in the traditional temperature‐swing adsorption. In a fixed bed, the desorption time of the photomodulation process was reduced by nearly half compared with the washing method with hot solvent, and the energy used can be saved by 46.2% in theory.
Monitoring Photoinduced Interparticle Chemical CommunicationIn Situ
Authors: Chen Mengjie , Lu Si‐Min , Wang Hao‐Wei , Long Yi‐Tao 
Published: January 2023

AbstractMonitoring interparticle chemical communication plays a critical role in the nanomaterial synthesis as this communication controls the final structure and stability of global nanoparticles (NPs). Yet most ensemble analytical techniques, which could only reveal average macroscopic information, are unable to elucidate NP‐to‐NP interactions. Herein, we employ stochastic collision electrochemistry to track the morphology transformation of Ag NPs in photochemical process at the single NP level. By further statistical analysis of time‐resolved current transients, we quantitatively determine the dynamic chemical potential difference and interparticle communication between populations of large and small Ag NPs. The high sensitivity of stochastic collision electrochemistry enables thein situinvestigation of chemical communication‐dependent transformation kinetics of NPs in photochemical process, shedding light on designing nanomaterials.
Synthese modifizierter Poly(vinylalkohole) und deren Abbau mittels einer enzymatischen Kaskade
Authors: von Haugwitz Gerlis , Donnelly Kian , Di Filippo Mara , Breite Daniel , Phippard Max , Schulze Agnes , Wei Ren , Baumann Marcus , Bornscheuer Uwe T. 
Published: January 2023

AbstractPoly(vinylalkohol) (PVA) ist ein wasserlösliches, synthetisches Vinylpolymer mit bemerkenswerten physikalischen Eigenschaften wie Thermostabilität und Viskosität. Trotz seiner geringen biologischen Abbaubarkeit werden große Mengen PVA in die Umwelt freigesetzt. Die etablierten physikalisch‐chemischen Abbauprozesse für PVA haben mehrere Nachteile, wie z. B. hohe Kosten, geringe Effizienz und Sekundärverschmutzung. Der biologische Abbau von PVA durch Mikroorganismen ist langsam und erfordert häufig Pyrrolochinolinchinon (PQQ)‐abhängige Enzyme, was ihn aufgrund des kostspieligen Kofaktors teuer und daher für industrielle Anwendungen unattraktiv macht. In dieser Studie stellen wir einen modifizierten PVA‐Film mit verbesserten Eigenschaften sowie eine PQQ‐unabhängige, neue enzymatische Kaskade für den Abbau von modifiziertem und unmodifiziertem PVA vor. Die Kaskade besteht aus vier Schritten, die von drei Enzymen katalysiert werden. Die Kofaktoren werden dabei in situ recycelt, sodass sich diese Kaskade auch für industrielle Anwendungen eignet.
Technologische Pfade für die Herstellung von komprimiertem und hochreinem Wasserstoff mit Hilfe von Sonnenenergie
Authors: Ivanova Mariya E. , Peters Ralf , Müller Martin , Haas Stefan , Seidler Martin Florian , Mutschke Gerd , Eckert Kerstin , Röse Philipp , Calnan Sonya , Bagacki Rory , Schlatmann Rutger , Grosselindemann Cedric , Schäfer Laura‐Alena , Menzler Norbert H. , Weber André , van de Krol Roel , Liang Feng , Abdi Fatwa F. , Brendelberger Stefan , Neumann Nicole , Grobbel Johannes , Roeb Martin , Sattler Christian , Duran Ines , Dietrich Benjamin , Hofberger M. E. Christoph , Stoppel Leonid , Uhlenbruck Neele , Wetzel Thomas , Rauner David , Hecimovic Ante , Fantz Ursel , Kulyk Nadiia , Harting Jens , Guillon Olivier 
Published: January 2023

AbstractWasserstoff (H2) aus erneuerbaren Energien wird einen wachsenden Einfluss auf die globale Energiedynamik hin zu nachhaltigen und kohlenstoffneutralen Standards haben. Der Anteil von grünem H2 ist noch zu gering, um das Netto‐Null‐Ziel zu erreichen, während die Nachfrage nach hochwertigem Wasserstoff weiter steigt. Diese Faktoren verstärken den Bedarf an wirtschaftlich tragfähigen H2‐Erzeugungstechnologien. Der vorliegende Artikel zielt darauf ab, die bestehenden Technologien zur Erzeugung von hochwertigem H2 auf der Grundlage von Solarenergie zu bewerten. Technologien wie die Wasserelektrolyse, die photoelektrochemische und die solare thermochemische Wasserspaltung, Flüssigmetallreaktoren und die Plasmakonversion nutzen die Sonnenenergie direkt oder indirekt (als kohlenstoffneutrale Elektronen) und werden im Hinblick auf ihren derzeitigen Entwicklungsstand, ihre technischen Grenzen und ihr Zukunftspotenzial untersucht.
An Aluminum Telluride with a Terminal Al=Te Bond and its Conversion to an Aluminum Tellurocarbonate by CO2 Reduction
Authors: Xu Huihui , Kostenko Arseni , Weetman Catherine , Fujimori Shiori , Inoue Shigeyoshi 
Published: January 2023

AbstractFacile access to dimeric heavier aluminum chalcogenides [(NHC)Al(Tipp)‐μ‐Ch]2 (NHC=IiPr (1,3‐diisopropyl‐4,5‐dimethylimidazol‐2‐ylidene, IMe4 (1,3,4,5‐tetramethylimidazol‐2‐ylidene); Tipp=2,4,6‐iPr3C6H2; Ch=Se, Te) by treatment of NHC‐stabilized aluminum dihydrides with elemental Se and Te is reported. The higher affinity of IMe4 in comparison with IiPr toward the Al center in [(NHC)Al(Tipp)‐μ‐Ch]2 can be used for ligand exchange. Additionally, the presence of excess IMe4 allows for cleavage of the dimers to form a rare example of a neutral multiply bonded heavier aluminum chalcogenide in the form of a tetracoordinate aluminum complex, (IMe4)2(Tipp)Al=Te. This species reacts with three equivalents of CO2 across two Al−CNHC and the Al=Te bond affording a pentacoordinate aluminum complex containing a dianionic tellurocarbonate ligand [CO2Te]2−, which is the first example of tellurium analogue of a carbonate [CO3]2−.
Synthesis of Modified Poly(vinyl Alcohol)s and Their Degradation Using an Enzymatic Cascade
Authors: von Haugwitz Gerlis , Donnelly Kian , Di Filippo Mara , Breite Daniel , Phippard Max , Schulze Agnes , Wei Ren , Baumann Marcus , Bornscheuer Uwe T. 
Published: January 2023

AbstractPoly(vinyl alcohol) (PVA) is a water‐soluble synthetic vinyl polymer with remarkable physical properties including thermostability and viscosity. Its biodegradability, however, is low even though a large amount of PVA is released into the environment. Established physical‐chemical degradation methods for PVA have several disadvantages such as high price, low efficiency, and secondary pollution. Biodegradation of PVA by microorganisms is slow and frequently involves pyrroloquinoline quinone (PQQ)‐dependent enzymes, making it expensive due to the costly cofactor and hence unattractive for industrial applications. In this study, we present a modified PVA film with improved properties as well as a PQQ‐independent novel enzymatic cascade for the degradation of modified and unmodified PVA. The cascade consists of four steps catalyzed by three enzymes with in situ cofactor recycling technology making this cascade suitable for industrial applications.
High Electron Mobility Hot‐Exciton Induced Delayed Fluorescent Organic Semiconductors
Authors: Zhang Y. , Gao C. , Wang P. , Liu Y. , Liu Z. , Xie W. , Xu H. , Dang Y. , Liu D. , Ren Z. , Yan S. , Wang Z. , Hu W. , Dong H. 
Published: January 2023

AbstractThe development of high mobility emissive organic semiconductors is of great significance for the fabrication of miniaturized optoelectronic devices, such as organic light emitting transistors. However, great challenge exists in designing key materials, especially those who integrates triplet exciton utilization ability. Herein, dinaphthylanthracene diimides (DNADIs), with 2,6‐extended anthracene donor, and 3′‐ or 4′‐substituted naphthalene monoimide acceptors were designed and synthesized. By introducing acceptor‐donor‐acceptor structure, both materials show high electron mobility. Moreover, by fine‐tuning of substitution sites, good integration with high solid state photoluminescence quantum yield of 26 %, high electron mobility of 0.02 cm2 V−1 s−1, and the feature of hot‐exciton induced delayed fluorescence were obtained in 4′‐DNADI. This work opens a new avenue for developing high electron mobility emissive organic semiconductors with efficient utilization of triplet excitons.
Metal‐Free Far‐Red Light‐Driven Photolysis via Triplet Fusion to Enhance Checkpoint Blockade Immunotherapy
Authors: Zeng Le , Jiang Lin‐Han , Li Jia‐Yao , Huang Ling , Chen Yongzhi , Yu Nuo , Wang Lei , Huang Kai , Peng Jing , Han Gang 
Published: January 2023

AbstractMetal‐free long‐wavelength light‐driven prodrug photoactivation is highly desirable for applications such as neuromodulation, drug delivery, and cancer therapy. Herein, via triplet fusion, we report on the far‐red light‐driven photo‐release of an anti‐cancer drug by coupling the boron‐dipyrromethene (BODIPY)‐based photosensitizer with a photocleavable perylene‐based anti‐cancer drug. Notably, this metal‐free triplet fusion photolysis (TFP) strategy can be further advanced by incorporating an additional functional dopant, i.e. an immunotherapy medicine inhibiting the indoleamine 2,3‐dioxygenase (IDO), with the far‐red responsive triplet fusion pair in an air‐stable nanoparticle. With this IDO inhibitor‐assisted TFP system we observed efficient inhibition of primary and distant tumors in a mouse model at record‐low excitation power, compared to other photo‐assisted immunotherapy approaches. This metal‐free TFP strategy will spur advancement in photonics and biophotonics fields.
Visible‐Light‐Induced N‐Heterocyclic Carbene‐Catalyzed Single Electron Reduction of Mono‐Fluoroarenes
Authors: Sheng He , Liu Qiang , Zhang Bei‐Bei , Wang Zhi‐Xiang , Chen Xiang‐Yu 
Published: January 2023

AbstractFluoroarenes are abundant and readily available feedstocks. However, due to the high reduction potentials of mono‐fluoroarenes, their photoreduction remains a continuing challenge, motivating the development of efficient activation modes to address this issue. This report presents the blue light‐induced N‐heterocyclic carbene (NHC)‐catalyzed single electron reduction of mono‐fluoroarenes for biaryl cross‐couplings. We discovered that under blue light irradiation, NHC/tBuOK combination could construct powerful photoactive architectures to promote single electron transfer for Caryl−F bond reduction via forming highly reducing NHC radical anion. Notably, the strategy was also successful to reduce Caryl−O, Caryl−N, and Caryl−S bonds for biaryl cross‐couplings.
Design, synthesis, molecular docking, and biological evaluation of coumarin‐thymidine analogs as potent anti‐TB agents
Authors: Reddy Dinesh S. , Sinha Anamika , Kurjogi Mahantesh M. , Shanavaz H. , Kumar Amit 
Published: January 2023

AbstractWith the intent to discover new antituberculosis (TB) compounds, coumarin‐thymidine analogs were synthesized using second‐order nucleophilic substitution reactions of bromomethyl coumarin with thymidine. The newly synthesized coumarin‐thymidine conjugates (1a–l) were characterized using IR, NMR, GC‐MS, and CHN elemental analysis. The novel conjugates were found to exhibit potent anti‐TB activity against the Mycobacterium tuberculosis H37Rv strain, with minimum inhibitory concentrations (MIC) of the active compounds ranging between 0.012 and 0.482 µM. Compound 1k was established as the most active candidate with a MIC of 0.012 µM. The toxicity study on HEK cells confirmed the nontoxic nature of compounds 1e, 1h, 1i, 1j, and 1k. Also, the most active compounds (1k, 1j, and 1e) were stable in the pH range from 2.5 to 10, indicating compatibility with the biophysical environment. Based on the pKa studies, compounds 1k, 1j, and 1e are capable of crossing lipid‐membrane barriers and acting on target cells. Molecular docking studies on the M. tuberculosis β‐oxidation trifunctional enzyme (PDB ID: 7O4V) were conducted to investigate the mechanisms of anti‐TB activity. All compounds showed excellent hydrogen binding interactions and exceptional docking scores against M. tuberculosis, which was in accordance with the results. Compounds 1a–l possessed excellent affinity to proteins, with binding energies ranging from −7.4 to −8.7 kcal/mol.
Exploiting waste derived from Musa spp. processing: Banana and plantain
Authors: Serna‐Jiménez Johanna Andrea , Siles López José Ángel , de los Ángeles Martín Santos María , Chica Pérez Arturo Fco 
Published: January 2023

AbstractBanana and plantain (Musa spp.) are among the most popular crops especially in tropical and sub‐tropical zones. Musa spp. is a unique, perennial, single‐harvest plant that after fruit harvesting is decapitated and generates large amounts of waste and by‐products: leaves and pseudostem. Fruit processing also generates waste peels and discarded pieces. Recent research has demonstrated that this type of organic substrate represents a potentially valuable resource that can be developed into high‐value products. These developments are critically reviewed in this article, which includes a summary of the composition and biocompounds contained in pseudostem and peel, the use of Musa spp. waste in animal and human feed and the obtention of fiber to make paper, rope, handcrafts and combustion materials. On the other hand, the potential for polysaccharides to be fermented and transformed into ethanol, methane or hydrogen, the obtention of single‐cell protein (microbial protein) and the use of solid residues for composting or as a substrate for mushrooms cultivation have also been evaluated. The applications described represent great opportunities for economic benefits from this agro‐industrial waste. A scheme for the integrated utilization of Musa spp. waste in a biorefinery approach is presented as well.
PemBla: A Phase 1 study of intravesical pembrolizumab in recurrent non‐muscle‐invasive bladder cancer
Authors: Woodcock Victoria K. , Chen Ji‐Li , Purshouse Karin , Butcher Chrissie , Collins Linda , Haddon Caroline , Verrall Gillian , Elhussein Leena , Roberts Corran , Tarlton Andrea , Rei Margarida , Napolitani Giorgio , Salio Mariolina , Middleton Mark R. , Cerundolo Vincenzo , Crew Jeremy , Protheroe Andrew S. 
Published: January 2023

AbstractObjectivesThis study aimed to investigate the anti‐PD‐1 inhibitor pembrolizumab as a potential agent for use in non‐muscle‐invasive bladder cancer (NMIBC) by conducting a Phase 1 safety run‐in study to assess the safety and tolerability of intravesical pembrolizumab after transurethral resection of the bladder tumour (TURBT).Patients and methodsEligible patients had recurrent NMIBC for which adjuvant treatment post TURBT was a reasonable treatment option, Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0–1 and adequate end‐organ function. Pembrolizumab was administered by intravesical instillation once weekly for a total of six doses. Intra‐patient dose escalation was performed in three paired patient cohorts with doses starting at 50 mg and increasing through 100 mg to a maximum of 200 mg. Adverse events (AEs) were assessed using Common Terminology Criteria for Adverse Events (CTCAE) v4.03 with dose limiting toxicity (DLT) defined as a clinically significant, drug‐related, Grade 4 haematological or Grade 3 or higher non‐haematological toxicity occurring within 7 days of administration of the first treatment at a given dose for that patient.ResultsSix patients were treated with no DLTs seen during dose escalation. Drug‐related AEs were of low grade and included dysuria and fatigue. All patients completed six doses of treatment as planned. Pharmacokinetic and pharmacodynamic assays did not detect any pembrolizumab in the serum following repeated intravesical administration, and no changes in peripheral immune cell populations were observed.ConclusionsAdministration of intravesical pembrolizumab was well tolerated and did not raise any safety concerns in patients with NMIBC following TURBT. There was no evidence of systemic absorption or systemic immune effects following intravesical administration. Further studies are required to assess whether intravesical administration has anti‐tumour activity.
Digital‐twin‐driven structural and electrochemical analysis of Li+ single‐ion conducting polymer electrolyte for all‐solid‐state batteries
Authors: Lee Jongjun , Byun Seoungwoo , Lee Hyobin , Roh Youngjoon , Jin Dahee , Lim Jaejin , Song Jihun , Dzakpasu Cyril Bubu , Park Joonam , Lee Yong Min 
Published: January 2023

AbstractThe electrode structure is a crucial factor for all‐solid‐state batteries (ASSBs) since it affects the electronic and ionic transport properties and determines the electrochemical performance. In terms of electrode structure design, a single‐ion conducting solid polymer electrolyte (SIC‐SPE) is an attractive solid electrolyte (SE) for the composite electrode among various SEs. Although the ionic conductivity of SIC‐SPE is lower than other inorganic SEs, the SIC‐SPE has a relatively lower density and can form an intimate contact between the SE and active materials (AM), resulting in an excellent electrode structure. The electrochemical performance of the cell with SIC‐SPE was comparable with the cell with Li6PS5Cl (LPSCl), which has 10 times higher intrinsic ionic conductivity than SIC‐SPE (SIC‐SPE: 0.2 × 10−3 S cm−1, LPSCl: 2.2 = 10−3 S cm−1 at 25°C). 3D digital‐twin‐driven simulation showed that the electrode with SIC‐SPE has a higher SE volume fraction, a lower tortuosity, and a larger AM/SE contact area than the LPSCl electrode. The favorable structure of the SIC‐SPE electrode leads to lower overpotential than the LPSCl electrode during operation. Our results suggest that the SIC‐SPE is a promising SE for making a good electrode structure in ASSBs.