bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning of bone metastasis in small cell lung cancer: A large sample-based study
Authors: Chen Qing , Liang Haifeng , Zhou Lei , Lu Hongwei , Chen Fancheng , Ge Yuxiang , Hu Zhichao , Wang Ben , Hu Annan , Hong Wei , Jiang Libo , Dong Jian 
Published: February 2023

IntroductionBone is a common metastatic site for small cell lung cancer (SCLC). Bone metastasis (BM) in patients have are known to show poor prognostic outcomes. We explored the epidemiological characteristics of BM in SCLC patients and create a new deep learning model to predict outcomes for cancer-specific survival (CSS) and overall survival (OS).Materials and MethodsData for SCLC patients diagnosed with or without BM from 2010 to 2016 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox proportional hazards regression models were used to evaluate the effects of prognostic variables on OS and CSS. Through integration of these variables, nomograms were created for the prediction of CSS and OS rates at 3-month,6- month,and 12-month. Harrell's coordination index, calibration curves,and time- dependent ROC curves were used to assess the nomograms' accuracy. Decision tree analysis was used to evaluate the clinical application value of the established nomogram.ResultsIn this study, 4201 patients were enrolled. Male sex, tumor size 25 but &lt;10, brain and liver metastases, as well as chemotherapy were associated with a high risk for BM. Tumor size, Age, N stage, gender, liver metastasis, radiotherapy as well as chemotherapy were shown to be prognostic variables for OS, and the prognostic variables for CSS were added to the tumor number in addition. Based on these results, nomograms for CSS and OS were established separately. Internal as well as external validation showed that the C-index, calibration cuurve and DCA had good constructive correction effect and clinical application value. Decision tree analysis further confirmed the prognostic factors of OS and CSS.DiscussionThe nomogram and decision tree models developed in this study effectively guided treatment decisions for SCLC patients with BM. The creation of prediction models for BM SCLC patients may be facilitated by deep learning models.
Combined analysis of multi-omics reveals the potential mechanism of flower color and aroma formation in Macadamia integrifolia
Authors: Wang Yonggui , Xia Jing , Wang Zile , Ying Zhiping , Xiong Zhi , Wang Changming , Shi Rui 
Published: February 2023

IntroductionMacadamia integrifolia Maiden &amp; Betche is a domesticated high-value nut crop. The development of nut flower affects the fruit setting rate, yield and quality of nuts. Therefore, in this experiment, two varieties with different flower color, flowering time, flowering quantity and nut yield (single fruit weight) were selected as the research objects.MethodsTranscriptome (RNA-Seq) and metabolome (LC-MS/MS, GC-MS) analyses were performed to study the regulatory mechanisms of nut flower development, color and aroma.ResultsThe results indicated that plant hormone signal transduction, starch sucrose metabolism, phenylpropanoid metabolism, flavonoid biosynthesis, and anthocyanin biosynthesis pathways were related to nut flower development and flower color formation. In the early stage of flowering, most of the differentially expressed genes (DEGs) are involved in the IAA signal transduction pathway, while in the later stage, the brassinolide signal pathway is mainly involved. In starch and sugar metabolism, DEGs are mainly involved in regulating and hydrolyzing stored starch into small molecular sugars in flower tissues. In the phenylpropanoid biosynthesis pathway, DEGs are mainly related to the color and aroma (volatile organic compounds, VOCs) formation of nut flowers. Four color formation metabolites (anthocyanins) in nut flowers were found by LC-MS/MS detection. In addition, the VOCs showed no significant difference between red nut flowers (R) and white nut flowers (W), which was mainly reflected in the aroma formation stage (flowering time). And 12 common differentially accumulation metabolites (DAMs) were detected by GC-MS and LC-MS/MS. At the same time, the DEGs, AAT, LOX and PAL genes, were also identified to regulate key metabolite synthesis during nut flower development. These genes were further verified by qRT-PCR.ConclusionOur results provide insights to clarify the molecular mechanism of color and aroma formation during M. integrifolia flower development that pave the way for nut quality and yield breeding.
Gambaran Foto Toraks pada Pasien Tuberkulosis Paru dengan Penyakit Ginjal Kronik di RSUP Prof. Dr. R. D. Kandou Periode Januari-Juni 2022
Authors: Safitri Dian A. , Mamesah Yovana P. M. , Timban Joan F. J. 
Published: January 2023

Abstract: Pulmonary tuberculosis (TB), a chronic disease caused by Mycobacterium tuberculosis, is still a world health problem. Chronic kidney disease (CKD) is also a significant global health problem. In CKD, the immune system dysfunction occurs in the form of cell-mediated immunity (CMI). This study aimed to find out the imaging of chest X-ray in tuberculosis patients with chronic kidney disease at Prof. Dr. R. D. Kandou Hospital, Manado, from January to June 2022. This was a retrospective and descriptive study with a cross sectional design. The results obtained 34 tuberculosis patients with CKD, dominated by males (76.5%) and patients aged 56-65 years (41.2%). Based on CKD status, the risk of tuberculosis increased in patients undergoing hemodialysis (52.9%). The most common characteristic of chest X-ray were infiltrates and fibrosis (79.4%) and the dominant combination lesions on chest X-ray were infiltrates, consolidation, and fibrosis (23.5%). The area of tuberculosis lesion was commonly found in the form of minimal lesion (47.1%). In conclusion, the most common chest X-ray profiles in tuberculosis patients with chronic kidney disease were infiltrates and fibrosis, and minimal lesion.
Keywords: chest X-ray; tuberculosis; chronic kidney disease

Absrtrak: Tuberkulosis (TB) paru disebabkan oleh Mycobacterium tuberculosis dan merupakan penyakit kronis yang masih menjadi masalah kesehatan dunia hingga saat ini. Penyakit ginjal kronis (PGK) juga merupakan masalah kesehatan global yang signifikan. Pada PGK terjadi disfungsi sistem imun berupa depressed cell-mediated immunity (CMI). Penelitian ini bertujuan untuk mendapatkan gambaran foto toraks pada pasien tuberkulosis dengan PGK di RSUP Prof. Dr. R. D. Kandou pada periode Januari–Juni 2022. Jenis penelitian ini ialah deskriptif retrospektif dengan desain potong lintang. Hasil penelitian mendapatkan 34 pasien tuberkulosis, didominasi oleh jenis kelamin laki-laki (76,5%) dan usia 56-65 tahun (41,2%). Berdasarkan status PGK, risiko terkena tuberkulosis lebih meningkat pada pasien yang dilakukan hemodialis (52,9%). Karakteristik pada gambaran foto toraks yang paling banyak ditemukan yaitu infiltrat dan fibrosis (79,4%), dan lesi kombinasi yang dominan pada gambaran foto toraks ialah infiltrat, konsolidasi, dan fibrosis (23,5%). Luas lesi pada tuberkulosis ditemukan lebih banyak pada lesi minimal (47,1%). Simpulan penelitian ini ialah gambaran foto toraks yang paling sering ditemukan pada pasien tuberkulosis dengan PGK ialah infiltrat dan fibrosis, serta lesi minimal.
Kata kunci: foto toraks; tuberkulosis; penyakit ginjal kronik
Gambaran Foto Toraks Pasien Tuberkulosis Paru dengan Diabetes Melitus di RSUP Prof. Dr. R. D. Kandou Periode Januari – Juni 2022
Authors: Tampubolon Putra Y. , Rondo Alfa G. E. Y. , Simanjuntak Martin L. 
Published: January 2023

Abstract: Pulmonary tuberculosis (pulmonary TB) is one of the ten leading causes of death world-wide. Diabetes mellitus is a group of metabolic diseases characterized by hyperglycaemia. Thus, this disease can exacerbate the symptoms and increase the reccurence rate of pulmonary TB. Chest X-ray examination is used to support the diagnosis of pulmonary tuberculosis. This study aimed to obtain the chest X-ray profile of pulmonary TB patients with diabetes mellitus at Prof. Dr. R. D. Kandou Hospital from January to June 2022. This was a retrospective and descriptive study with a cross sectional design. The results obtained 21 patients of pulmonary TB with diabetes mellitus dominated by females (61.9%) and age group of 46-55 years (33.3%). The most common chest X-ray characteristic was fibrosis (95.2%). The most dominant degree of severity was far advanced lesion (61.9%). In conclusion, in this study the majority of pulmonary tuberculosis patients with diabetes mellitus were females and age group of 46-55 years. The most common chest X-ray characteristic was fibrosis with far advanced lesion.
Keywords: chest X-ray; pulmonary tuberculosis; diabetes mellitus

Abstrak: Tuberkulosis paru (TB paru) merupakan salah satu dari sepuluh penyebab kematian terbesar di dunia. Diabetes melitus merupakan kelompok penyakit metabolik dengan karakteristik hiperglikemia. Penyakit ini dapat memperparah gejala TB paru dan meningkatkan angka kekam-buhan penyakit TB paru. Untuk menunjang diagnosis TB paru digunakan pemeriksaan foto toraks. Penelitian ini bertujuan untuk mengetahui gambaran foto toraks pada pasien TB paru dengan diabetes melitus di RSUP Prof. Dr. R. D. Kandou periode Januari–Juni 2022. Hasil penelitian mendapatkan 21 pasien TB paru dengan diabetes melitus di RSUP Prof. Dr. R. D. Kandou, didomi-nasi oleh jenis kelamin perempuan (61,9%). Berdasarkan kelompok usia, yang paling dominan ialah kelompok usia 46-55 tahun (33,3%). Gambaran foto toraks yang paling sering ditemukan ialah fibrosis (95,2%). Derajat keparahan yang paling mendominasi ialah dengan luas lesi far advanced (61,9%). Simpulan penelitian ini ialah mayoritas pasien tuberkulosis paru dengan diabetes melitus ditemukan pada perempuan dengan kelompok usia 46-55 tahun. Gambaran foto toraks yang paling sering ditemukan ialah fibrosis dengan lesi far advanced.
Kata kunci: foto toraks; tuberkulosis paru; diabetes melitus
Korelasi Lama Menyandang Diabetes Melitus dan HbA1c dengan Estimasi Laju Filtrasi Glomerulus pada Pasien Diabetes Melitus Tipe 2
Authors: Kombe Afdriansyah L. , Sugeng Cerelia E. C. , Sedli Bisuk P. 
Published: January 2023

Abstract: Diabetes mellitus (DM) is a group of metabolic diseases characterized by high blood sugar levels (hyperglycemia) that occur due to abnormalities in insulin secretion, insulin action, or both. Poor blood sugar control in the long term can cause various diseases, one of which is chronic kidney disease. This study aimed to determine the correlation between duration of DM and HbA1c (glycated hemoglobin) with estimated glomerular filtration rate (eGFR) in type 2 DM patients. This was an analytical study with a retrospective approach and a cross-sectional design. were taken by using consecutive sampling technique. Data of HbA1c and eGFR were obtained from the patient's medical record. Duration of suffering from diabetes mellitus was carried out by interviewing the patients. Data were analyzed using the Pearson and Spearman correlation statistical tests. The results obtained 38 type 2 DM patients as respondents. The correlation test between duration of DM and eGFR showed a significant negative correlation (r=-0.411; p=0.01), and the correlation test between HbA1c correlation test and eLFG showed a non-significant negative correlation (r=-0.109; p=0.516). In conclusion, there is a significant negative correlation between duration of DM and eGFR and a non-significant negative correlation between HbA1c and eGFR.
Keywords: duration of diabetes mellitus; glycated hemoglobin; estimated glomerular filtration rate

Abstrak: Diabetes melitus merupakan kelompok penyakit metabolik yang memiliki karakteristik kadar gula tinggi (hiperglikemia) yang terjadi karena kelainan sekresi insluin, kerja insulin atau keduanya. Kontrol gula darah yang buruk secara jangka panjang dapat menimbulkan berbagai penyakit salah satunya penyakit ginjal kronik. Penelitian ini bertujuan untuk untuk mengetahui korelasi lama menyandang DM dan HbA1c (glycated hemoglobin) dengan eLFG (estimasi laju filtrasi glomerulus) pada pasien DM tipe 2. Jenis penelitian ialah analitik dengan pendekatan retrospektif serta menggunakan desain potong lintang. Responden penelitian diambil dengan teknik consecutive sampling. Data HbA1c dan eLFG diperoleh melalui rekam medik pasien. Pengambilan data lama menyandang DM dilakukan dengan wawancara pada pasien. Pada penelitian ini digunakan uji statistik korelasi Pearson dan Spearman. Hasil penelitian mendapatkan sebanyak 38 responden. Hasil uji korelasi antara lama menyandang DM dengan eLFG menunjukkan korelasi negatif bermakna (r=-0,411; p=0,01), dan hasil uji korelasi HbA1c dengan eLFG menunjukkan korelasi negatif tidak bermakna (r=-0,109; p=0,516). Simpulan penelitian ini ialah terdapat korelasi negatif yang bermakna antara lama menyandang diabetes melitus dengan eLFG dan korelasi negatif tidak bermakna antara HbA1c dengan eLFG.
Kata kunci: lama menyandang diabetes melitus; glycated hemoglobin; estimasi laju filtrasi glomerulus
Marketing Policy for Micro, Small, and Medium Enterprises Products After the COVID-19 Pandemic in Sontang Village, Bonai Darussalam District, Rokan Hulu Regency, Riau Indonesia (Study: Salai Fish Products (Smoked Fish))
Authors: Nurman Nurman , Hamsal Hamsal , Fadli Mashur 
Published: January 2023

Micro, Small, and Medium Enterprises (MSMEs) are economic businesses carried out by the lower middle class. This business aims to grow and develop its business to support efforts to reduce poverty and poverty and provide new job opportunities. In general, there are three (3) types of businesses that include MSMEs, namely (1) culinary businesses, (2) fashion businesses, and (3) agribusiness businesses. Making salai fish is a culinary business. The raw materials from fishermen's catches are then processed into the final product, which has added value. The object of this study is marketing policies ranging from products, prices, and distribution to promotions. The results showed that procedures in the field of production if you want to increase the income of the production process are carried out twice a week, policies in the area of prices depend on the high low purchasing power of end consumers, policies in the place of distribution try to shorten distribution channels because the longer the distribution channel affects income, and procedures in the business of promotion if the interest of end consumers decreases, it is thought that it is necessary to collaborate with partners such as houses eating, self-service and other services, expanding the market can be done by communicating, increasing selling places and increasing promotions by utilizing online media so that any product produced is sold out, and it is also suggested to MSME entrepreneurs to start cultivating river fish for the long term of the salai fish business
Model of Start Up Management to Strengthen Student Entrepreneurship Program in The MERDEKA Campus
Authors: Ida Hindarsah  , Yuce Sariningsih  , Yusep Ikrawan  , Heri Erlangga  , Erik  , Andry Mochamad Ramdan  
Published: January 2023

The government's seriousness towards the growth and development of entrepreneurship is felt by universities. One of them is the birth of the Free Learning and Independent Campus (MBKM) program. The Merdeka Campus programs aim to prepare students to become graduates who have the competencies needed in the future and as respond to digital transformation that is happening globally has pushed Indonesia to become a country that excels in giving first to start-up. The research purposes to investigate the implementation of start-up management to strengthen student entrepreneurship program. This research will be conducted at Pasundan University. The method used is the Mix Method approach, namely a quantitative approach (survey) supplemented by qualitative data (interviews and Focus Group Discussions). The survey was conducted to 54 active student respondents at the University, as well as Focus Group Discussions. The results showed that the effect of creativity and innovation on motivation was 42,5% and motivation on management was 33,9%. Due to the small management influence, tools are needed to help improve start-up capabilities in increasing profits, market size and productivity through online interactions with business websites.
Implementasi Pendidikan Merdeka Belajar Di MI Miftahus Sa’adah Ngawi Terhadap Minat Bakat Siswa
Authors: Farihuromadhon Syamsudin 
Published: January 2023

<p>Artikel ini menjelaskan tentang praktik baik Merdeka Belajar. Pendidikan merdeka belajar merupakan respon terhadap kebutuhan sistem pendidikan pada era Revolusi Industri 4.0. Praktik baik merdeka belajar yang dilakukan oleh guru kelas 6 di MI Miftahus Sa’adah. Penelitian ini bertujuan untuk mengetahui pengaruh dari merdeka belajar terhadap pembelajaran di MI Miftahus Sa’adah.</p><p>Metode yang digunakannya yaitu penelitian kualitatif dengan guru Bahasa Indonesia sebagai objek pertama dan murid sebagai objek kedua. Untuk mengumpulkan data dalam penelitian ini digunakan instrument observasi dan instrument interview guru.</p><p>Dalam artikel ini akan disampaikan cara pembelajaran yang menarik yang digunakan guru MI Miftahus Sa’adah dengan konsep merdeka belajar. Dengan demikian para siswa dapat memperoleh ilmu dengan rasa senang.</p><p><strong>Kata kunci</strong>: <em>Implementasi Merdeka Belajar, Minat Bakat Siswa, Pendidikan</em></p><p> </p>
Peningkatan Keterampilan Menulis Karangan Deskripsi Menggunakan Metode Field Trip Siswa Sekolah Dasar
Authors: Dewi Anggun Yunita , Pebriana Putri Hana , Ananda Rizki , Pahrul Yolanda , Sumianto Sumianto 
Published: January 2023

Penelitian ini dilatar belakangi oleh rendahnya hasil keterampilan menulis karangan siswa kelas IV tahun ajaran 2022/2023. Penelitian ini bertujuan untuk meningkatkan keterampilan menulis karangan deskripsi siswa kelas IV Sekolah Dasar Negeri 013 Pangkalan Kerinci dengan metode Field Trip. Penelitian ini dilaksanakan di SDN 013 Pangkalan Kerinci. Subjek yang digunakan sebanyak 24 orang siswa yang terdiri dari 16 orang siswa laki-laki dan 8 siswa perempuan. Metode penelitian yang digunakan adalah Penelitian Tindakan Kelas yang dilakukan dalam dua siklus yang setiap siklus terdiri dari dua kali pertemuan. Instrumen pengumpulan data dilakukan dengan tes menulis karangan deskripsi, lembar observasi guru dan siswa sebagai tingkat keterlaksanaan dan pencapaian dalam menggunakan metode Field Trip. Teknik analisis data dilakukan secara deskripsi kualitatif dan kuantitatif. Berdasarkan hasil analisis data dapat diketahui terdapat peningkatan keterampilan menulis karangan deskripsi siswa pada muatan pelajaran Bahasa Indonesia. Data awal pratindakan ketuntasan belajar 25%, pada siklus I pertemuan I meningkat menjadi 33%, siklus I pertemuan II meningkat menjadi 54% kemudian pada siklus II pertemuan I meningkat menjadi 67%, dan siklus II pertemuan II meningkat lagi menjadi 92%. Dengan demikian dapat disimpulkan dengan metode Field Trip dapat meningkatkan Keterampilan Menulis Karangan Deskripsi Siswa Kelas IV SDN 013 Pangkalan Kerinci.<div> </div><div>Kata kunci: Keterampilan Menulis Karangan Deskripsi, Field Trip, dan Sekolah Dasar.</div>
Partisipasi Peserta Didik SD Dalam Proses Pembelajaran Berbasis Teknologi Pada Blended Learning
Authors: Rohmah Ovi Taufiqu , Julia Julia , Syahid Aah Ahmad 
Published: January 2023

<p><em>Penelitian ini dilatar belakangi oleh partisipasi yang sangat penting dalam proses pembelajaran, yaitu peserta didik. Penelitian ini dilakukan untuk melihat seberapa pentingnya partisipasi didik pada saat pelaksanaan pembelajaran menggunakan media pembelajaran yang berbasis teknologi. Penelitian ini menggunakan pendekatan riset kualitatif dengan desain penelitiaan studi kasus untuk mengetahui secara mendalam. Subjek dalam penelitian ini di uji cobakan kepada peserta didik kelas IV SD Negeri Baginda II Kabupaten Sumedang. Berdasarkan hasil pembahasan daripenelitian ini, tingkatan partisipasi peserta didik pada saat proses pembelajaran berlangsung menggunakan media yang berbasis teknologi dilihat dari tiga aspek antara lain partisipasi peserta didik dalam bertanya, partisipasi peserta didik dalam menanggapi persoalan, serta partisipasi peserta didik dalam mengerjakan tugas. Partisipan menyadari jika berpartisipasi dalam proses pembelajaran ialah hal yang sangat penting, dikarenakan perihal tersebut ialah kunci dari tercapainya tujuan pembelajaran. Hasil diarahkan dari hasil observasi, dan angket yang diberikan kepada peserta didik di SD Negeri Baginda II Kabupaten Sumedang bahwa peserta didik mampu berpartisipasi aktif sepanjang proses pembelajaran walaupun belum sepenuhnya. Jadi, dapat disimpulkan bahwa peserta didik berpartisipasi aktif selama proses pembelajaran yang menggunakan media berbasis teknologi secara luring (tatap muka).</em></p><p><strong><em> </em></strong></p>
Pengaruh Kapasitas Kelembagaan dan Komunikasi terhadap Kinerja Dewan Perwakilan Rakyat Daerah Provinsi Kepulauan Bangka Belitung
Authors: Vitaloka Diah , Hamdi Muchlis , Rowa Hyronimus , Mulyati Deti 
Published: January 2023

Fenomena yang dijadikan obyek penelitian adalah Kinerja DPRD Provinsi. Tujuan penelitian adalah membahas pengaruh Kapasitas Kelembagaan dan Komunikasi terhadap Kinerja DPRD Provinsi Kepulauan Bangka Belitung dan menyusun konsep baru dari pembahasan pengaruh tersebut. Penelitian menggunakan penelitian kuantitatif. Sampel penelitian 186 responden diambil dari populasi 351 menggunakan Tabel Krejcie. Teknik pengumpulan data menggunakan studi kepustakaan, teknik kuesioner dan observasi. Analisis data menggunakan Analisis SEM. Hasil penelitian adalah berikut: Besarnya pengaruh Kapasitas kelembagaan terhadap Kinerja DPRD Provinsi Kepulauan Bangka Belitung mencapai 0,64, terbilang kuat dan signifikan. Besarnya pengaruh Komunikasi terhadap Kinerja DPRD Provinsi Kepulauan Bangka Belitung mencapai 0,58,<strong> </strong>terbilang cukup kuat dan signifikan. Konsep baru yang dapat disusun dari analisis hasil pengaruh Kapasitas Kelembagaan terhadap Kinerja DPRD Provinsi Kepulauan Bangka Belitung adalah Konsep Baru tentang Susunan Kelembagaan Legislatif dengan definisi : Susunan Kelembagaan Legislatif adalah tata jabatan dan koordinasi pelaksanaan tugas dan wewenang fraksi, komisi dan lembaga legislative dalam mengimplementasikan fungsi-fungsi kelembagaan. Konsep baru yang dapat disusun dari analisis pengaruh Komunikasi terhadap Kinerja DPRD Provinsi Kepulauan Bangka Belitung adalah Konsep Baru tentang Komunikasi Lisan dan Tulisan Legislatif, dengan definisi : Komunikasi Lisan dan Tulisan<strong> </strong>adalah kemahiran individual dan kemahiran kolektif anggota legislative dalam mengelola informasi pelaksanaan fungsi-fungsi kelembagaan yang dinyatakan dengan orasi, sosialisasi, argumentasi, publikasi.