bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of physical activity levels and dietary habits between women with polycystic ovarian syndrome and healthy controls of reproductive age: A case-control study
Authors: Butt Muhammad Salman , Saleem Javeria , Zakar Rubeena , Aiman Sobia , Bukhari Gul Mehar Javaid , Fischer Florian 
Published: January 2023

AbstractBackground Polycystic ovarian syndrome (PCOS) is a reproductive hormonal anomaly prevalent among reproductive-aged women, with an alarmingly high prevalence of 52% among Pakistani women. This study aims to compare the daily physical activity and dietary habits of PCOS women with age-matched healthy controls living in Lahore, Pakistan. Methods A case-control study design was used to collect data from a private hospital situated in Lahore, Pakistan. Data were collected from 115 participants of the reproductive age group (18–45 years). Demographic variables, reproductive characteristics, anthropometric measurements, and 7 days of physical activity levels using the international physical activity questionnaire (IPAQ-Short version) and 7 days of food frequency questionnaire (7 days-FFQ) were used to measure the dietary habits of the participants. Mosby’s Nutritac v4.0 software was used to estimate the macronutrients, vitamins, and minerals present in diet intake. The glycemic index and glycemic load were calculated to compare the quality and quantity of carbohydrate consumption between the two groups. Results The 49 newly identified PCOS cases using Rotterdam criteria aged 24.63 years (SD ± 4.76) and 66 healthy controls aged 23.24 years (SD ± 5.45) were compared. A significant difference (p ≤ 0.05) was found for reproductive characteristics, daily physical activity, polyunsaturated fat, and vitamin intake between the two groups. Binary logistic regression analysis showed that food with a low glycemic index (GI ≤ 40) reduced the odds of PCOS occurrence by OR = 1.94. Similarly, food nutrients with a low glycemic load (GL ≤ 10) can lower PCOS occurrence by OR = 1.60. Conclusion The daily physical activity levels and dietary habits of reproductive-aged women can influence their reproductive characteristics and polycystic ovarian morphology. A diet with a low glycemic load and index can produce beneficial reproductive health effects among reproductive-aged women.
Investigating air travel network changes in Canada, USA and Europe during COVID-19 using open source data
Authors: Ciupeanu Adriana-Stefania , Wickramasinghe Ashani , Muthukumarana Saman , Arino Julien 
Published: January 2023

Abstract
We consider the evolution of the global air transportation network during the COVID-19 pandemic, using publicly available data from the OpenSky Network.
Fundamental abrasive contact at high speeds: scratch testing in experiment and simulation
Authors: Varga Markus , Cervellón Alejandra Marcela Ventura , Leroch Sabine , Eder Stefan Josef , Rojacz Harald , Ripoll Manel Rodríguez 
Published: January 2023

Abstract

The understanding and experimentation of abrasive wear mechanisms at high speeds is still poorly investigated in literature. This is mainly due to a lack of suitable, well-instrumented test rigs for fundamental, single abrasive wear events. Standard scratch tests, which are often utilized for studies of abrasion phenomena, operate in the low-speed range up to some mm/s, while applications suffering from abrasive wear often operate at speeds exceeding 1 m/s (e.g., rolling, grinding, machining).
Numerical approaches, especially particle-based methods, allow the simulation of such fast deformation processes, but rely on hardening models that require a precise knowledge of material parameters. Thus, the Johnson-Cook material model was parametrized using data from high-speed compression tests of pure aluminum. A series of scratch tests with increasing depths were then simulated using the particle-based Material Point Method (MPM). Experimentation was done on a pendulum scratch test rig equipped with a Rockwell C diamond cone. By adjusting the balance point of the swing arm of ~1 m length, a velocity of 6.8 m/s was achieved at its tip as measured with a high-speed camera. Scratches of several depths were performed, and their force signals acquired. Post-test analyses comprised topography measurements and EBSD on cross-sections of the scratches to investigate the microstructural changes due to the high-speed wear event.
Scratch topographies and abrasive mechanisms compared favorably between experiment and simulation for the aluminum. The extent of strain hardening was significantly reduced compared to low-speed experiments. The calibration of the high-speed force sensor was successful and now allows the investigation of new alloys and determination of material parameters under high-speed abrasive conditions.
Hilbert’s First Problem and the New Progress of Infinity Theory
Authors: Wang Xijia 
Published: January 2023

Abstract
In the 19th century, Cantor created the infinite cardinal number theory based on the "1-1 correspondence" principle. The continuum hypothesis is proposed under this theoretical framework. In 1900, Hilbert made it the first problem in his famous speech on mathematical problems, which shows the importance of this question. We know that the infinitesimal problem triggered the second mathematical crisis in the 17-18th centuries. The Infinity problem is no less important than the infinitesimal problem. In the 21st century, Sergeyev introduced the Grossone method from the principle of "whole is greater than part", and created another ruler for measuring infinite sets. The discussion in this paper shows that, compared with the cardinal number method, the Grossone method enables infinity calculation to achieve a leap from qualitative calculation to quantitative calculation. According to Grossone theory, there is neither the largest infinity and infinitesimal, nor the smallest infinity and infinitesimal. Hilbert's first problem is caused by the incompleteness of the infinity theory.
Chemoradiation therapy for localized colorectal cancer: a view from the outside
Authors: Akhmetzyanov F. Sh. , Egorov V. I. , Abdulganieva G. R. 
Published: January 2023

Background. Colorectal cancer is among the most lethal and prevalent malignances in the world. The management of localized colorectal cancer is highly debated. Surgical resection of the rectum, such as total mesenteric excision (TME) is usually associated with significant morbidity and mortality. The integration of various chemotherapy options into the standard treatment of localized rectal cancer could potentially enhance the tumor control with a subsequent reduction in the frequency of recurrence, thus improving overall and disease-free survival. Moreover, there are categories of patients for whom surgical treatment is contraindicated and chemotherapy will be more useful for them. Although rectal cancer is predominantly a disease of older patients, current guidelines do not incorporate optimal treatment recommendations for elderly patients with comorbidities; therefore this issue remains a matter of debate.Aim. We aimed to consider alternative approaches to the treatment of localized rectal cancer and the management of selected patients with this diagnosis.Material and Methods. We searched for publications in the Pubmed, eLibrary databases and up-to-date information on the basis of world cancer associations.Conclusions. Comparison of surgery with concurrent chemoradiotherapy for localized rectal cancer showed that in some cases neoadjuvant therapy can be useful and successful, acting as an ideal alternative. However, this approach may be suitable for selected patients who meet certain criteria. In addition, a follow-up care after treatment should include a specific range of diagnostic imaging tests.
Impact of the СOVID-19 pandemic on cancer incidence in patients undergoing cancer screening during annual health checkup (population-based study)
Authors: Valkova L. E. , Dyachenko A. A. , Merabishvili V. M. , Bogdanov D. V. , Berezin A. V. , Potekhina E. F. , Valkov M. Yu. 
Published: January 2023

Background. During the COVID-19 pandemic, annual adult check-ups have been postponed, resulting in cancer screening disruption.The aim of the study was to evaluate changes in the incidence and stage distribution of malignancies included in the screening program during the COVID-19 pandemic using the Arkhangelsk Regional Cancer Registry (ARRC).Material and Methods. We assessed the changes of the incidence rates and stage distribution for the colon, rectum, lung, breast, cervix, uterine body, ovary, prostate and kidney cancers over the periods 2018–19 and 2020–21. Results. A total of 12354 cases with 9 cancers were selected: 6680 for the period 2018–19 and 5674 (-15.1 %) for the period 2020-21. The most significant decrease in crude and age-standardized incidence rates was registered in patients with lung (-18.0–18.1 %), rectum (-25.1–25.9 %) and cervix (-33.6–36.9 %) cancers, p<0.001. The decrease was not signifcant in patients with breast, uterine body, and kidney cancers. The proportion of patients with stage I decreased in lung cancer (-20.0 %, from 14.8 % to 11.8 %), rectum (-20.2 %, from 20.9 % to 16.7 %), and uterine cervix (-37.1 %, from 53.2 % to 33.5 %). In prostate and kidney cancers, the proportion of patients with stage I increased by 30 % (from 19.5 % to 25.4 %) and 17.6 % (from 45.9 % to 54.0 %), respectively. A signifcant reduction in the proportion of early stages during the COVID-19 pandemic was observed in lung and cervical cancer. Conclusion Postponed health checkups due to COVID-19 pandemic disruptions have led to substantial reductions in new cancers being diagnosed, mainly for cervical, lung, colon and rectal cancers. No signifcant changes were observed for other cancers. Further analysis of mortality and survival of cancer patients is required. Key words: health checkup, cancer screening, COVID-19 pandemic, cancer incidence, stage distribution>˂0.001. The decrease was not significant in patients with breast, uterine body, and kidney cancers. The proportion of patients with stage I decreased in lung cancer (-20.0 %, from 14.8 % to 11.8 %), rectum (-20.2 %, from 20.9 % to 16.7 %), and uterine cervix (-37.1 %, from 53.2 % to 33.5 %). In prostate and kidney cancers, the proportion of patients with stage I increased by 30 % (from 19.5 % to 25.4 %) and 17.6 % (from 45.9 % to 54.0 %), respectively. A significant reduction in the proportion of early stages during the COVID-19 pandemic was observed in lung and cervical cancer.Conclusion. Postponed health checkups due to COVID-19 pandemic disruptions have led to substantial reductions in new cancers being diagnosed, mainly for cervical, lung, colon and rectal cancers. No significant changes were observed for other cancers. Further analysis of mortality and survival of cancer patients is required.
PERCEPCIONES DOCENTES SOBRE LA PANDEMIA DEL COVID-19 COMO CONTENIDO CURRICULAR EMERGENTE EN EL CONTEXTO DE APRENDIZAJE
Authors: Manrique-Villavicencio Lileya , Figueroa Iberico Angela Maria , Ruiz Olaya Jorge 
Published: January 2023

La pandemia del COVID-19 trajo repercusiones en distintos niveles y generó nuevos aprendizajes que no formaban parte del currículo escolar, pero se reconocen como necesarios para ayudar a los estudiantes a comprender la situación que viven y gestionar su agencia. Precisamente, debido a la necesidad de informar y educar sobre la prevención y el cuidado, se incorpora en el currículo escolar la pandemia del COVID-19 como un contenido emergente, vinculado con una problemática que sobreviene sin más, gracias a la cual es necesario revisar y cuestionar de forma crítica (Anguita et al., 2010; Dego y Ferraz, 2008). Este estudio cualitativo busca explorar las percepciones docentes sobre la incorporación de la pandemia del COVID-19, como contenido emergente en la implementación del currículo y los aportes de dicho contenido en los estudiantes y sus familias, durante la educación remota (abril 2020 y julio 2021). Se entrevistaron a dieciocho docentes de dos escuelas del Cercado de Lima. La pandemia representó un contenido emergente y estructurador, alrededor del cual se vincularon diversos contenidos conceptuales, prácticas, hábitos y actitudes, incorporados a través de la programación de experiencias significativas, la integración de áreas curriculares, en actividades permanentes y de tutoría. Los docentes perciben un currículo flexible que les permitió adaptar la propuesta oficial a la realidad y necesidades de sus estudiantes. La pandemia aportó aprendizajes centrados en la práctica de nuevos hábitos de cuidado personal y de salud, así como la importancia de valores como la solidaridad y resiliencia, entre otros.
Accrualls and systematic risk in Brazilian companies
Authors: Oliveira Junior José Luciano de , Nossa Valcemiro , Nossa Silvania Neris , Oliveira Edvan Soares 
Published: January 2023

Purpose: The objective of this study was to investigate whether the systematic risk of companies listed on the Brazilian Stock Exchange (B3) is affected by the quality of accounting information. Additionally, it was verified if the systematic risk was affected differently after the mandatory adoption of IFRS in Brazil.
Methodology: The sample comprised all companies with observations listed on the Brazilian stock exchange (B3) from 2005 to 2021. Empirical research was carried out with descriptive analysis and a quantitative approach. Data were estimated in a panel with fixed effects. The total value of the accruals of Dechow and Dichev (2002) and Jones (1991) were used as measures of the quality of accounting information. The systematic risk measures were estimated using market models and three factors by Fama and French (1993).
Results: In general, companies that have higher quality accounting information are able to reduce information asymmetry problems, which increase systematic risk, thus, having higher quality in this information reduces the risk to the investor.
Contributions of the Study: The results of this paper bring practical contributions to the market and investors, who can feel more secure due to clarity and confidence in the information. Even with the adoption of IFRS in Brazil, the main conclusion of our research is that it actually contributes to the quality of information being converted into lower risks.
Preparation, Characterization and Drug Delivery Research of
γ-Polyglutamic Acid Nanoparticles: A Review
Authors: Liu Zhihan , He Yan , Ma Xia 
Published: January 2023

Abstract:
γ-Polyglutamic acid is a kind of biomaterial and environmentally friendly polymer material
with the characteristics of water solubility and good biocompatibility. It has a wide range of applications
in medicine, food, cosmetics and other fields. This article reviews the preparation, characterization
and medical applications of γ-polyglutamic acid nanoparticles. Nanoparticles prepared by using γ-
polyglutamic acid not only had the traditional advantages of enhancing drug stability and slow-release
effect, but also were simple to prepare without any biological toxicity. The current methods of nanoparticle
preparation mainly include the ion gel method and solvent exchange method, which use the total
electrostatic force, van der Waals force, hydrophobic interaction force and hydrogen bond force between
molecules to embed materials with different characteristics. At present, there are more and more
studies on the use of γ-polyglutamic acid to encapsulate drugs, and the research on the mechanism of its
encapsulation and sustained release has gradually matured. The development and application of polyglutamic
acid nanoparticles have broad prospects.
COMPARATIVE CALORIFIC ANALYZES OF COCONUT SHELL AND DURIAN FRUIT PEEL BY USING DIFFERENTIAL SCANNING CALORIMETRY
Authors: Gunawan Safri , Nursanni Banu , Januariyansah Sapitri , Suprapto Suprapto 
Published: January 2023

The production of coconut and durian means that it will produce a lot of waste from its shell. Indonesia is a country that produces a lot of them. The coconut shell (CS) and durian fruit peel (DFP) can be converted to briquette as new fuel from biomass. The objective of this research is to obtain the calorific briquette properties of CS and DFP using Differential Scanning Calorimetry (DSC). The material composition consist of 10 % and 15 % of starch for each CS and DFP. Thermal treatment was carried out in the temperature range of 28 °C to 600 °C at 5.4 °C/min. The addition of starch causes the heating temperature since it has thermoplastic properties. Additionally, it is difficult to burn and carries a lot of water so that the heat generated is used to evaporate the water first of all in the briquettes. The recommended material is CS with 10 % mass of starch. The optimum temperature reached was 578.97 °C with an enthalpy value of 0.42 J/g.
CareKnowDo—A Multichannel Digital and Telephone Support Program for People With Chronic Kidney Disease: Feasibility Randomized Controlled Trial
Authors: Reston Riley Elizabeth , Caskey Fergus J , Hole Barnaby , Udayaraj Udaya , Weinman John 
Published: January 2023

Background
Chronic kidney disease (CKD) is a common, progressive condition. Lifestyle changes and antihypertensive medication can slow the progression to end-stage kidney disease, which requires renal replacement therapy. However, adherence to these recommendations is often low.

Objective
The aim of CareKnowDo was to assess the feasibility of rolling out a digital self-management support and adherence program integrated with a patient-facing electronic health record, Patient View (PV).

Methods
A 2-arm, parallel, individual-level pragmatic feasibility pilot randomized controlled trial was conducted at 2 National Health Service (NHS) sites in the United Kingdom. A total of 61 patients with CKD were randomized 1:1 into 2 groups and provided with either a new, tailored digital and telephone support program (CareKnowDo: 31/61, 51%) integrated with PV or standard care (PV alone: 30/61, 49%). Quantitative measures included clinical and psychosocial measures. The primary outcomes were feasibility based: recruitment rate, dropout, and the exploration of associations.

Results
Of the 1392 patients screened in local kidney clinics, 269 (19.32%) met the basic inclusion criteria; the first 22.7% (61/269) who met the eligibility criteria were recruited to participate in the study. Of the 69 patients, 23 (38%) patients completed the final 6-month follow-up web-based survey. Reasons for the attrition were explored. A higher belief in the ability of the treatment to control CKD was associated with lower blood pressure at baseline (r=0.52; P=.005), and a higher perceived understanding of CKD at baseline was associated with lower blood pressure at follow-up (r=0.66; P<.001). Beliefs about medicines at baseline were associated with blood pressure at baseline but not at follow-up. This was true for both concerns about medicines (r=0.58; P=.001) and perceived necessity of medicines (r=0.42; P=.03).

Conclusions
A tailored digital and nurse call–based program to enhance support for patients with CKD was piloted in 2 NHS sites and found to be feasible and acceptable. However, to maximize the effectiveness of the intervention (and of future trials), consideration should be given to the target audience most likely to benefit, as well as how to help them access the program as quickly and easily as possible.

Trial Registration
NHS Health Research Authority, IRAS ID 184206; https://www.hra.nhs.uk/planning-and-improving -research/application-summaries/research-summaries/careknowdo-pilot-version-1/
Users’ Reactions to Announced Vaccines Against COVID-19 Before Marketing in France: Analysis of Twitter Posts
Authors: Dupuy-Zini Alexandre , Audeh Bissan , Gérardin Christel , Duclos Catherine , Gagneux-Brunon Amandine , Bousquet Cedric 
Published: January 2023

Background
Within a few months, the COVID-19 pandemic had spread to many countries and had been a real challenge for health systems all around the world. This unprecedented crisis has led to a surge of online discussions about potential cures for the disease. Among them, vaccines have been at the heart of the debates and have faced lack of confidence before marketing in France.

Objective
This study aims to identify and investigate the opinions of French Twitter users on the announced vaccines against COVID-19 through sentiment analysis.

Methods
This study was conducted in 2 phases. First, we filtered a collection of tweets related to COVID-19 available on Twitter from February 2020 to August 2020 with a set of keywords associated with vaccine mistrust using word embeddings. Second, we performed sentiment analysis using deep learning to identify the characteristics of vaccine mistrust. The model was trained on a hand-labeled subset of 4548 tweets.

Results
A set of 69 relevant keywords were identified as the semantic concept of the word “vaccin” (vaccine in French) and focused mainly on conspiracies, pharmaceutical companies, and alternative treatments. Those keywords enabled us to extract nearly 350,000 tweets in French. The sentiment analysis model achieved 0.75 accuracy. The model then predicted 16% of positive tweets, 41% of negative tweets, and 43% of neutral tweets. This allowed us to explore the semantic concepts of positive and negative tweets and to plot the trends of each sentiment. The main negative rhetoric identified from users’ tweets was that vaccines are perceived as having a political purpose and that COVID-19 is a commercial argument for the pharmaceutical companies.

Conclusions
Twitter might be a useful tool to investigate the arguments for vaccine mistrust because it unveils political criticism contrasting with the usual concerns on adverse drug reactions. As the opposition rhetoric is more consistent and more widely spread than the positive rhetoric, we believe that this research provides effective tools to help health authorities better characterize the risk of vaccine mistrust.