bluuebunny/crossref_metadata_2025_split huggingface dataset:
Could tumour volume and major and minor axis based on CTA statistical anatomy improve the pre‐operative T‐stage in oesophageal cancer?
Authors: Wang Runyuan , Zhang Xiaoqin , Wu Wei , Ma Jinfeng , Chen Jincheng , Zhang Zhu , Liu Liqun , Xu Shanshan , Cao Ximei , Wu Yi , Cui Huilin 
Published: June 2023

AbstractObjectivesTo statistically study the 3D shape of oesophageal cancer (EC) and its spatial relationships based on computed tomography angiography (CTA) 3D reconstruction, to determine its relationship with T‐stages, and to create an optimal T‐stage diagnosis protocol based on CTA calculation.MethodsPre‐operative CTA images of 155 patients with EC were retrospectively collected and divided into four groups: T1–T4. We used Amira software to segment and 3D reconstruct the EC, oesophagus, aorta, pericardium and peripheral lymph nodes and measured their surface area, volume, major axis, minor axis, longitudinal length, roughness and relationship to the aorta of the EC. One‐way ANOVA, independent sample t‐test, ROC, etc., were performed and critical values between different T‐stages were calculated. We also invited two radiologists to evaluate the measurements.ResultsThere were no significant differences in EC longitudinal length, roughness score and relationship with the aorta between the different T‐stages of EC. There were significant differences in EC surface area, EC volume and mean major and minor axis among the different T‐stages. The volumes of the T1–T4 tumours were 12,934.36 ± 7739.25, 23,095.27 ± 14,975.67, 37,577.98 ± 36,085.64 and 58,579.25 ± 41,073.96 mm3 separately (p < 0.05), and the T1–T4 volume cut‐off values were 11,712.00, 19,809.00 and 44,103.50 mm3 separately. For comparison with radiologists, the AUC value of our measurements was 0.704, which was higher than the radiologists of AUC = 0.630.ConclusionsEC volume, major and minor axis can be used as important factors for surgeons in the T‐stage diagnosis of EC, which helps to improve prognosis and treatment decisions after CTA.
Comparison of efficacy and safety of second‐ and third‐generationTKIsfor non‐small‐cell lung cancer with uncommonEGFRmutations
Authors: Hao Yue , Xu Manyi , Jin Jianan , Si Jinfei , Xu Chunwei , Song Zhengbo 
Published: June 2023

AbstractBackgroundThe efficacy of definite for non‐small‐cell lung cancer (NSCLC) with uncommon epidermal growth factor receptor (EGFR) mutations has been preliminarily demonstrated. However, there is a paucity of data with which to compare the efficacy and safety of second‐ and third‐generation TKIs in patients with NSCLC carrying uncommon EGFR mutations.MethodsWe compared the efficacy and safety of second‐ and third‐generation TKIs in all NSCLC patients in whom next‐generation sequencing confirmed uncommon EGFR mutations, including G719X, S768I, and L861Q. The parameters analyzed included the objective response rate (ORR), disease control rate (DCR), progression‐free survival (PFS), and overall survival (OS). The rate of treatment‐related adverse events (AEs) reflected the safety of these TKIs.ResultsEighty‐four NSCLC patients with uncommon EGFR mutations were enrolled between April 2016 and May 2022 at Zhejiang Cancer Hospital, including 63 treated with second‐generation TKIs and 21 treated with third‐generation TKIs. The ORR for all patients receiving TKIs was 47.6%, and the DCR was 86.9%. The median PFS for NSCLC patients with uncommon EGFR mutations receiving TKIs was 11.9 months and OS was 30.6 months. There was no significant difference in PFS after treatment with second‐ or third‐generation TKIs (13.3 vs. 11.0 months, respectively,P = 0.910) or in OS (30.6 vs. 24.6 months, respectivelyP = 0.623). The third‐generation TKIs showed no severe toxicity.ConclusionsThe efficacy of second‐ and third‐generation TKIs for NSCLC with uncommon EGFR mutations does not differ, and so can be used to treat NSCLC patients with these mutations.
Synthesis, Characterization, and Biological Evaluation of Cu(II) Complexes Containing Triflupromazine with Glycine and Histidine
Authors: Sultan Nourhan S. , Elhakim Heba K. A. , Shoukry Azza A. , Rashidi Fatma B. 
Published: June 2023

AbstractTwo novel copper (II) complexes [Cu(TFP)(Gly)Cl] ⋅ 2H2O complex (1) and [Cu(TFP)(His)Cl] ⋅ 2H2O complex (2) are synthesized, where TFP stands for trifluropromazine, Gly. represents glycine, and His. is histidine. Chemical composition, IR, mass spectra, and magnetic susceptibility tests are performed. Complex binding with macromolecules was investigated using UV‐vis, viscosity, gel electrophoresis, and fluorescence quenching. Fluorescence spectroscopy revealed that each complex could replace ethidium bromide (EB). These complexes exhibit grooved, non‐covalent, and electrostatic interactions with CT‐DNA. Spectroscopy analysis of the BSA interaction showed that complexes bind to protein (Kb values for (1) is 5.89×103 M−1 and for (2) is 9.08×103 M−1) more strongly than CT‐DNA (Kb values for (1) is 5.43×103 M−1 and for (2) is 7.17×103 M−1). Molecular docking analysis and spectral absorption measurements showed high agreement. Antimicrobial, antioxidant, and anti‐inflammatory properties were tested in vitro. The druggability of complex (2) should be tested in vivo as it is more biologically active.
Systematic pan‐cancer analysis identified neuropilin 1 as an immunological and prognostic biomarker
Authors: Ma Xiao , Zhao Yang , Shi Congcong , Jiang Hong , Liu Haonan , Wang Hongmei , Qin Xiaobing , Wang Yuqin , Han Zhengxiang 
Published: June 2023

AbstractNeuropilin 1 (NRP1) is a transmembrane glycoprotein, nontyrosine kinase receptor that plays an important role in axonal growth and angiogenesis in the nervous system. Although currently more and more studies have shown that NRP1 plays an important role in some cancers, no systematic pan‐cancer analysis of NRP‐1 has been performed to date. Therefore, we aimed to investigate the associated immune function and prognostic value of NRP1 in 33 tumors of various cancer types. In this study, based on The Cancer Genome Atlas, Cancer Cell Line Encyclopedia, Genotype Tissue Expression, cBioportal for cancer genomics, and Human Protein Atlas (HPA databases), various bioinformatics analysis methods were used to investigate the potential carcinogenic effects of NRP1 activation, pan‐cancer analysis of NRP1 expression, and the relationship between NRP1 expression and prognosis indicators including overall survival, disease‐specific survival, disease‐free interval, and progression‐free interval, tumor mutational burden (TMB), and microsatellite instability (MSI). The results showed that NRP1 was highly expressed in most tumors. In addition, NRP1 was found to be positively or negatively correlated with the prognosis of different tumors. Also, the expression of NRP1 was associated with TMB and MSI in in 27 and 21 different types of tumors, respectively, and with DNA methylation in almost all the various types of tumors. The expression of the NRP1 gene was negatively correlated with the infiltration levels of most immune cells. In addition, the correlation between the level of immune cell infiltration and NRP1 expression varied according to immune cell subtype. Our study suggests that NRP1 plays an important role in tumor development and tumor immunity and could potentially be used as a prognostic indicator in a variety of malignancies.
An esthetic, functional, and low‐invasive lower red lip reconstruction using a mucosal perforator flap: A case report
Authors: Yamakawa Sho , Suda Shota , Hayashida Kenji 
Published: June 2023

Key Clinical MessageLower red lip reconstruction using a mucosal perforator flap is low‐invasive and adheres to the concept of “like with like.” The location of the mucosal perforator can easily be detected using color Doppler ultrasound.AbstractLip reconstructions should provide results of a high degree regarding both functionality and esthetics. We describe a case of lower red lip reconstruction using a mucosal perforator. An 81‐year‐old man complained of repeated bleeding from a submucosal venous malformation on his lower red lip, and surgery was performed under local anesthesia. The venous malformation was completely resected. A 4 cm × 2 cm triangle‐shaped flap containing a mucosal perforator, identified using color Doppler ultrasound preoperatively, was designed in the lower red lip adjacent to the defect. The perforator flap was raised in the submucosal layer, and the defect was covered with the flap in an advancement manner. The flap transfer‐related defect was closed, and at the one‐year follow‐up examination, no recurrence, drooling, or speech impediment was observed. In this case, excellent functional and esthetic results were achieved following the low‐invasive reconstruction using a mucosal perforator flap.
Isolated benign persistent proteinuria with novel association of CUBN (cubilin) variants
Authors: Shi Vivian , Stein Quinn , Clark Dinah , Punj Sumit , Kremsdorf Robin , Faizan Mohammed 
Published: June 2023

Key Clinical MessageWe present two siblings with persistent proteinuria and normal kidney function, each carrying the same compound heterozygous variants in the CUBN gene. The CUBN‐related phenotype appears to be dependent upon both variant type and the domain site within the gene. Knowledge of CUBN status may allow for avoidance of invasive testing.
Pd‐Catalyzed Intramolecular Hydroaminocarbonylation of 3‐Allyl‐4‐arylaminocoumarins: Synthesis of Six‐ and Seven‐membered Ring Lactams Fused to the Coumarin Scaffold
Authors: Almaraz Karla , Amézquita‐Valencia Manuel 
Published: June 2023

AbstractA protocol has been developed for the synthesis of six‐ and seven‐membered ring lactams fused to coumarins through a hydroaminocarbonylation reaction catalyzed by palladium. The catalytic system (PdBr2/Xantphos) provided a strategy for the synthesis of seven‐membered ring lactams with good isolated yield and regioselectivity. Control of selectivity by the substrate in the synthesis of six‐membered ring lactams was observed. Control reactions showed the importance of the hydrogen in the cyclocarbonylation reaction, and NMR data supported the role of the hydride palladium species as a catalytic precursor. A preliminary screening of the cytotoxic activity of coumarin‐fused lactams against six cancer cell lines was evaluated. The biological tests indicated that both the size of the heterocycle and presence of a substituent on the aromatic ring affected the inhibition of cell growth.
Cyclotrimerization Approach to Symmetric [9]Helical Indenofluorenes: Diverting Cyclization Pathways
Authors: Cadart Timothée , Gläsel Tim , Císařová Ivana , Gyepes Róbert , Nečas David , Hapke Marko , Kotora Martin 
Published: June 2023

AbstractCatalytic cyclotrimerization routes to symmetrical [9]helical indenofluorene were explored by using different transition–metal complexes and thermal conditions. Depending on the reaction conditions, the cyclotrimerizations were accompanied by dehydro‐Diels–Alder reaction giving rise to another type of aromatic compounds. Structures of both symmetrical [9]helical cyclotrimerization product as well as the dehydro‐Diels–Alder product were confirmed by single‐crystal X‐ray diffraction analyses. Limits of enantioselective cyclotrimerization were assessed as well. DFT calculations shed light on the reaction course and the origin of diminished enantioselectivity.
Polymers of Intrinsic Microporosity Based on Dibenzodioxin Linkage: Design, Synthesis, Properties, and Applications
Authors: Pathak Chayanika , Gogoi Abinash , Devi Arpita , Seth Saona 
Published: June 2023

AbstractThe development of polymers of intrinsic microporosity (PIMs) over the last two decades has established them as a distinct class of microporous materials, which combine the attributes of microporous solid materials and the soluble nature of glassy polymers. Due to their solubility in common organic solvents, PIMs are easily processable materials that potentially find application in membrane‐based separation, catalysis, ion separation in electrochemical energy storage devices, sensing, etc. Dibenzodioxin linkage, Tröger's base, and imide bond‐forming reactions have widely been utilized for synthesis of a large number of PIMs. Among these linkages, however, most of the studies have been based on dibenzodioxin‐based PIMs. Therefore, this review focuses precisely on dibenzodioxin linkage chemistry. Herein, the design principles of different rigid and contorted monomer scaffolds are discussed, as well as synthetic strategies of the polymers through dibenzodioxin‐forming reactions including copolymerization and postsynthetic modifications, their characteristic properties and potential applications studied so far. Towards the end, the prospects of these materials are examined with respect to their utility in industrial purposes. Further, the structure‐property correlation of dibenzodioxin PIMs is analyzed, which is essential for tailored synthesis and tunable properties of these PIMs and their molecular level engineering for enhanced performances making these materials suitable for commercial usage.
Molecular Donor‐Acceptor Dyads for Single‐Material Organic Solar Cells
Authors: Aubele Anna , Kraus Teresa , Schmid Sylvia , Mena‐Osteritz Elena , Bäuerle Peter 
Published: June 2023

AbstractA series of ambipolar covalently linked oligothiophene‐fullerene dyads have been synthesized by systematical structural variations. In this respect, the length of linker between donor and acceptor unit was altered and in a second series the terminal acceptor units in the donor unit of the dyads were varied. Characterization of the optical and redox properties gave valuable structure‐property relationships and were correlated to the photovoltaic performance in single‐material organic solar cells, in which power conversion efficiencies of up to 4.3 % were reached.
Advances in Transition‐Metal‐Catalyzed Hydrogermylation of Alkenes and Alkynes†
Authors: Zhao Zungui , Zhang Furen , Wang Dongyang , Deng Liang 
Published: June 2023

Comprehensive SummaryHydrogermylation of alkenes and alkynes provides a straightforward synthetic route to organogermanium compounds that have been found applications in organic synthesis, medicinal chemistry, and material science. This paper reviews the advances in transition‐metal‐catalyzed hydrogermylation of unsaturated carbon‐carbon bonds, including alkenes, alkynes, dienes, and allenes, with the objective of providing readers with the status of the field. Progress, problems, and perspectives in this field are discussed.
Hierarchical Sponge‐Hydrogel Hybrid Structures with Robust Interfaces†
Authors: Zhang Pei , Chen Guangda , Chen Xingmei , Xing Junfei , Tao Yue , Liu Ji 
Published: June 2023

Comprehensive SummarySoft materials including elastomers and hydrogels are playing critical roles in a variety of fields, including bioelectrodes, batteries, supercapacitors, biomedical scaffolds, and solar vapor absorbents. Integrating hydrophobic sponges (i.e., mechanical robustness, elasticity and macroscopic porous structure) and hydrophilic hydrogels (i.e., autonomous water absorption and transportation, biocompatibility) within one unit could readily combine the complementary characters from each component, making a number of future research directions and applications possible. We propose a simple yet effective strategy to construct sponge‐hydrogel hybrid structures with robust hydrophobic‐hydrophilic interface. The sponge scaffold imparts the sponges‐hydrogel hybrids with desirable mechanical robustness, elasticity and macroscopic pores. On the other hand, the incorporated hydrogel component endows the hybrids with high water content (98 wt% hydrogel and 2 wt% sponge), superior compatibility, and nanoscale pores allowing for storage and transportation of various chemical and biological molecules. We further demonstrate that the introduction of hydrophilic hydrogel components could effectively improve the liquid absorption capability, blood coagulation rate, hemostatic capacity and hemocompatibility, thus promising as hemostatic agents.
Breast cancer risk characteristics of women undergoing whole‐breast ultrasound screening versus mammography alone
Authors: Sprague Brian L. , Ichikawa Laura , Eavey Joanna , Lowry Kathryn P. , Rauscher Garth , O’Meara Ellen S. , Miglioretti Diana L. , Chen Shuai , Lee Janie M. , Stout Natasha K. , Mandelblatt Jeanne S. , Alsheik Nila , Herschorn Sally D. , Perry Hannah , Weaver Donald L. , Kerlikowske Karla 
Published: June 2023

AbstractBackgroundThere are no consensus guidelines for supplemental breast cancer screening with whole‐breast ultrasound. However, criteria for women at high risk of mammography screening failures (interval invasive cancer or advanced cancer) have been identified. Mammography screening failure risk was evaluated among women undergoing supplemental ultrasound screening in clinical practice compared with women undergoing mammography alone.MethodsA total of 38,166 screening ultrasounds and 825,360 screening mammograms without supplemental screening were identified during 2014–2020 within three Breast Cancer Surveillance Consortium (BCSC) registries. Risk of interval invasive cancer and advanced cancer were determined using BCSC prediction models. High interval invasive breast cancer risk was defined as heterogeneously dense breasts and BCSC 5‐year breast cancer risk ≥2.5% or extremely dense breasts and BCSC 5‐year breast cancer risk ≥1.67%. Intermediate/high advanced cancer risk was defined as BCSC 6‐year advanced breast cancer risk ≥0.38%.ResultsA total of 95.3% of 38,166 ultrasounds were among women with heterogeneously or extremely dense breasts, compared with 41.8% of 825,360 screening mammograms without supplemental screening (p < .0001). Among women with dense breasts, high interval invasive breast cancer risk was prevalent in 23.7% of screening ultrasounds compared with 18.5% of screening mammograms without supplemental imaging (adjusted odds ratio, 1.35; 95% CI, 1.30–1.39); intermediate/high advanced cancer risk was prevalent in 32.0% of screening ultrasounds versus 30.5% of screening mammograms without supplemental screening (adjusted odds ratio, 0.91; 95% CI, 0.89–0.94).ConclusionsUltrasound screening was highly targeted to women with dense breasts, but only a modest proportion were at high mammography screening failure risk. A clinically significant proportion of women undergoing mammography screening alone were at high mammography screening failure risk.
Associations of low‐carbohydrate diets with breast cancer survival
Authors: Farvid Maryam S. , Spence Nicholas D. , Rosner Bernard A. , Barnett Junaidah B. , Holmes Michelle D. 
Published: June 2023

AbstractBackgroundThe objective of this study was to evaluate the role of low‐carbohydrate diets after breast cancer diagnosis in relation to breast cancer–specific and all‐cause mortality.MethodsFor 9621 women with stage I–III breast cancer from two ongoing cohort studies, the Nurses’ Health Study and Nurses’ Health Study II, overall low‐carbohydrate, animal‐rich low‐carbohydrate, and plant‐rich low‐carbohydrate diet scores were calculated by using food frequency questionnaires collected after breast cancer diagnosis.ResultsParticipants were followed up for a median 12.4 years after breast cancer diagnosis. We documented 1269 deaths due to breast cancer and 3850 all‐cause deaths. With the use of Cox proportional hazards regression and after controlling for potential confounding variables, we observed a significantly lower risk of overall mortality among women with breast cancer who had greater adherence to overall low‐carbohydrate diets (hazard ratio for quintile 5 vs. quintile 1 [HRQ5vsQ1], 0.82; 95% CI, 0.74–0.91; ptrend = .0001) and plant‐rich low‐carbohydrate diets (HRQ5vsQ1, 0.73; 95% CI, 0.66–0.82; ptrend < .0001) after breast cancer diagnosis but not animal‐rich low‐carbohydrate diets (HRQ5vsQ1, 0.93; 95% CI, 0.84–1.04; ptrend = .23). However, greater adherence to overall, animal‐rich, or plant‐rich low‐carbohydrate diets was not significantly associated with a lower risk of breast cancer–specific mortality.ConclusionsThis study showed that greater adherence to low‐carbohydrate diets, especially plant‐rich low‐carbohydrate diets, was associated with better overall survival but not breast cancer–specific survival among women with stage I–III breast cancer.
Dual immunocytochemical staining of annexin A10 and p53 in low‐grade and papillary urothelial carcinoma contributes to improvement of diagnostic accuracy in urine cytology
Authors: Kobayashi Go , Hayashi Tetsutaro , Sentani Kazuhiro , Uraoka Naohiro , Shibata Jun , Nobuhiro Ryosuke , Saito Yoichi , Ishida Katsunari , Kaneko Yoshie , Ikeda Kenichiro , Hanamoto Masanori , Nose Hiroyuki , Arihiro Koji , Hinata Nobuyuki , Oue Naohide 
Published: June 2023

AbstractBackgroundUrothelial carcinoma (UC) is a common type of human cancer and, although urine cytology is a useful method for identifying high‐grade UC (HGUC), its ability to diagnose low‐grade UC (LGUC) is limited. The authors previously reported that annexin A10 (ANXA10) expression was strongly linked to both papillary and early stage LGUC and was inversely correlated with p53 expression in upper tract UC (UTUC) and bladder UC. However, it remains largely unknown whether ANXA10 is useful as a diagnostic marker for urine cytology.MethodsIn this study, the authors used 104 biopsy and 314 urine cytology samples to investigate the efficacy of ANXA10 and p53 expression by immunohistochemistry and immunocytochemistry.ResultsIn immunohistochemistry analysis, expression levels of ANXA10 and p53 were either weak or absent in noncancerous tissues, whereas ANXA10 overexpression was observed patients with LGUC, and strong expression of p53 was identified in patients with HGUC. In immunocytochemistry analysis, sensitivity was not good for the detection of UC, especially UTUC, by cytology alone, but it was improved by combining cytology with ANXA10 and p53 to detect both bladder UC and UTUC. Receiver operating characteristic curve analysis also confirmed the diagnostic superiority of cytology combining ANXA10 and p53 for the detection of all UCs, including both HGUC and LGUC (area under the curve, 0.84).ConclusionsTo the authors’ knowledge, this is the first report that the combination of ANXA10 and p53 has potential application as a diagnostic immunomarker for improving the diagnostic accuracy of urine cytology.