bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between bile amylase levels and morphological changes in the biliary mucosa in pediatric patients with congenital biliary dilatation
Authors: Korai Takahiro , Nui Akihiro , Nishibori Shigeki , Yokoyama Shinichiro , Hashimoto Satsuki , Ishimura Riku , Hamada Hiromi 
Published: August 2023

Abstract
Purpose: This study aimed to investigate the relationship between bile and serum amylase (AMY) levels and changes in the biliary epithelium in patients with pancreaticobiliary maljunction (PBM).
Methods: This study included children with congenital biliary dilatation (CBD) of Todani types Ia, Ic, and IVa who underwent surgery at the Hokkaido Medical Center for Child Health and Rehabilitation between November 2007 and June 2023. We retrospectively investigated the relationship between the preoperative bile and serum AMY levels and clinicopathological findings.
Results: This study included 43 patients with CBD. Pathologically, all cases had hyperplasia in the gallbladder and bile duct epithelium, with dysplasia observed in 13 cases, but no carcinoma. A comparison between the patients with and without dysplasia revealed that a total exposure to AMY ≥662,400 IU/L in the bile was an independent risk factor predictive of dysplasia. There was a strong positive correlation between the total exposure to AMY in bile and serum (Spearman's rank correlation coefficient, 0.822, p<0.01).
Conclusion: Total exposure to AMY in bile is an independent risk factor for the development of dysplasia in the biliary mucosa. The total exposure to AMY in serum could be a substitute marker for total exposure to AMY in bile.
Ag(I) and Hg(II) coordination polymers decorated from fully benzimidazole substituted cyclotriphosphazene ligand and adsorption behaviour against Methylene Blue
Authors: Pendar Afranur , Duyar Ceyda , Zorlu Yunus , Davarcı Derya 
Published: August 2023

Abstract
Herein, we reported new two coordination polymers, {[Ag(L)](CH3PhSO3)](CH3CN)4}n (cp-1) and {[Hg(L)](Cl2)](CH3CN)2}n(cp-2), were synthesized from hexapodal benzimidazole substituted cyclotriphosphazene, (L). L was characterised by 1H NMR, 31P NMR and mass analysis. Structure of each isolated compounds were determined by single crystal X-ray crystallography. In cp-1, L has a κ3N coordination mode by connecting three Ag(I) ions to constitute a 2D coordination framework whereas the ligand in cp-2 displays κ2N coordination mode via linking four Hg(II) ions together to create a 1D coordination polymer. Topologically, cp-1 has a 3-connected uninodal net having the point symbol {4.82}. Dye adsorption studies of coordination polymers was performed out using UV-Vis. absorption spectroscopy. Adsorption experiments show that cp-1 and cp-2 removes the cationic methylene blue (MB) from water but shows no adsorption behaviour toward the anionic methyl orange (MO) and tartrazine (E102).
Preparation of Hierarchical TS-1 Molecular Sieve Membrane Catalyst and Its Catalytic Performance for Chloropropylene Epoxidation
Authors: Yang Zhaosheng , Tang Guoqiang , Li Yichuan , Niu Xiaoyue , Cheng Lingyao , Chai Yongming 
Published: August 2023

Abstract
TS-1 molecular sieve spherical membranes loaded on small-sized carriers with hierarchical pore structures and high framework-titanium contents could both exhibit high catalytic performances and facilitate the separation from the products after the reaction. In this paper, a simple in situ static crystallization method was used to achieve the construction of hierarchical porous TS-1 molecular sieve membranes on the surfaces of 400-µm spherical carriers using cetyltrimethylammonium bromide (CTAB) and soluble starch as mesoporous templating agents. Through the catalyst characterization and performance evaluation, soluble starch was finally selected as the mesoporous templating agent, and the film-forming mechanism was investigated by examining the effects of the proportion of precursor liquid and the crystallization conditions. In the chloropropene epoxidation reaction, the effective utilization of H2O2 and the selectivity of epichlorohydrin (ECH) reached 96.72% and 93.85%, respectively.
The Evidence Mismatch in Pediatric Surgical Practice
Authors: Broomfield Marina , Agabani Zena , Guadagno Elena , Poenaru Dan , Baird Robert 
Published: August 2023

Abstract
Purpose
Outpatient pediatric surgical practice often involves conditions of limited morbidity but significant parental concern. We explore existing evidence-based management recommendations and the mismatch with practice patterns for four common outpatient pediatric surgical conditions.
Methods
Using the Cochrane Rapid Review Group recommendations and librarian oversight, we conducted a rapid review of 4 outpatient surgical conditions: dermoid cysts, epigastric hernias, hydroceles, and umbilical hernias. We extracted patient demographics, intervention details, outcome measures and evaluated justifications presented for chosen management options. A metric of evidence volume (patient/publication ratio) was generated and compared between diagnoses.
Results
Out of 831 articles published since 1990, we identified 49 cohort studies (10-dermoid cyst, 6-epigastric hernia, 25-hydrocele, and 8- umbilical hernia). The 49 publications included 34,172 patients treated across 18 countries. The evidence volume for each out-patient condition demonstrates <1 cohort/condition/year. The evidence mismatch rate varied between 33-75%; many existing recommendations are not evidence-based, sometimes conflicting and frequently misrepresentative of clinical practice.
Conclusions
Published literature concerning common outpatient pediatric surgical conditions is sparse and demonstrates wide variations in practice. All individual practice choices were justified using either risk of complications or patient preference. Most early intervention practices were based on weak or outdated studies and “common wisdom” rather than genuine evidence.
Level of evidence: III
Differentially Private Knowledge Graph Neural Network for Recommeder System
Authors: 胡 Ce , 刘 白松 
Published: August 2023

Abstract
Knowledge Graphs (KGs) have been instrumental in mitigating the challenges of cold start and data scarcity in recommender systems, serving as a kind of auxiliary information. However, recent studies reveal that KGs, while beneficial, may also inadvertently furnish malicious attackers with more comprehensive background knowledge, escalating the risk of user privacy data breaches within these recommender systems. Current frameworks, which amalgamate KGs with privacy-preserving techniques, predominantly concentrate on enhancing privacy preservation, often at the expense of recommendation efficacy. In this research, we introduce a framework, named Differential Privacy Knowledge graph Neural network for Recommender systems (DPKNRec), designed to harmonize the trade-off between differential privacy noise and recommendation performance. Firstly, we formulate an integrated KG convolutional neural network adept at mining interrelationships between KG entities and item correlations effectively. Secondly, we incorporate a differential privacy technique to impose uniform Laplacian noise on feature embeddings and obfuscate genuine user-item interactions through pseudo-interaction item sampling, thereby augmenting user data security. Lastly, we evaluate our model using three distinct datasets-movies, music, and books. Empirical results from three benchmarks indicate that DPKNRec markedly supersedes contemporary benchmarks.
Immunotherapeutic IL-6R and Targeting the MCT-1/IL-6/CXCL7/PD-L1 Circuit Prevent Relapse and Metastasis of Triple-Negative Breast Cancer
Authors: Haq Aushia Tanzih Al , Yang Pao-Pao , Jin Christopher , Shih Jou-Ho , Chen Li-Mei , Tseng Hong-Yu , Chen Yen-An , Weng Yueh-Shan , Wang Lu-Hai , Snyder Michael P. , Hsu Hsin-Ling 
Published: August 2023

Abstract
Background
Multiple copies in T-cell malignancy 1 (MCT-1) is a prognostic biomarker for aggressive breast cancers. Overexpressed MCT-1 stimulates the IL-6/IL-6R/gp130/STAT3 axis, which promotes epithelial-to-mesenchymal transition, cancer stemness and tumor progression.
Methods
We studied the mechanism underlying triple-negative breast cancer (TNBC) immunity and aggressiveness and assessed primary tumor invasion, postsurgical local recurrence and distant metastasis in orthotopic syngeneic mice given the indicated immunotherapy and MCT-1 silencing (shMCT-1).
Results
We found that shMCT-1 suppresses the transcriptomes of the inflammatory response and metastatic signaling in TNBC cells and inhibits tumor recurrence, metastasis and mortality in xenograft mice. IL-6R immunotherapy and shMCT-1 combined further decreased intratumoral M2 macrophages and T regulatory cells (Tregs) and avoided postsurgical TNBC expansion. IL-6R-based immunotherapy more effectively prevented postsurgical TNBC metastasis, recurrence and mortality than anti-PD-L1 immunotherapy. Anti-IL-6R improved helper T, cytotoxic T and natural killer (NK) cells in the lymphatic system and decreased Tregs in recurrent and metastatic tumors, but anti-PD-L1 incapably elevated NK cells. Combined IL-6R and PD-L1 immunotherapies abridged TNBC cell stemness and M2 macrophage activity to a greater extent than monotherapy. Sequential immunotherapy of PD-L1 and IL-6R demonstrated the best survival outcome and lowest postoperative recurrence and metastasis compared with synchronized therapy, particularly in the shMCT-1 context. Multiple positive feedforward loops of the MCT-1/IL-6/IL-6R/CXCL7/PD-L1 axis were identified in TNBC cells, which boosted metastatic niches and immunosuppressive microenvironments. MCT-1high/PD-L1high/CXCL7high and CXCL7high/IL-6high/IL-6Rhigh expression patterns predict worse prognosis and poorer survival of breast cancer patients.
Conclusion
Systemic targeting of the MCT-1/IL-6/IL-6R/CXCL7/PD-L1 interconnections enhances immune surveillance that inhibits the aggressiveness of TNBC.
CDC42SE2 modulates epithelial-mesenchymal transition and tumor metastasis in colorectal cancer through CDC42 and downstream IQGAP3 signaling
Authors: Xiao Kun , Pe Wenting , Jiang Jiayu , Dong Kangdi , Zhang Jizhun 
Published: August 2023

Abstract
By GWAS and fine mapping study, SNP rs1010208 was identified to be a risk locus of colorectal cancer (CRC). By eQTL-based analysis of SNP rs1010208, gene CDC42SE2 was confirmed as potential target gene of SNP rs1010208. However, there was little research about CDC42SE2 and CRC, while CDC42SE2 was demonstrated to be associated with patient prognosis and tumor onset risk. Here we aimed to investigate the role of CDC42SE2 on CRC progression. CDC42SE2 expression in CRC tissue, adjacent normal tissue and CRC cell lines and its relationship with clinicopathological parameters were investigated. In vitro and in vivo assays were used to explore the function of CDC42SE2 in the progression of CRC. The study showed that CDC42SE2 was down-expressed in CRC tissues and associated with poor prognosis and high TNM stages. Overexpression of CDC42SE2 can inhibit the proliferation, metastasis and invasion ability and increase the apoptosis ratio of CRC cells. Furthermore, the in vivo results showed that CDC42SE2 overexpression resulted in lower tumor size in xenograft mice model using stably CDC42SE2-overexpressing CRC cells. Moreover, our study demonstrated that CDC42SE2 can suppress CDC42 and downstream IQGAP3 signaling and thus inhibit the epithelial-mesenchymal transition and invasive potential of CRC cells.In conclusion, CDC42SE2 is a new anti-oncogene of CRC and plays its role in inhibiting epithelial-mesenchymal transition and tumor metastasis by suppressing CDC42 and downstream IQGAP3.
Correlation between preoperative and postoperative alignment and kinematic gait in total knee arthroplasty
Authors: Liu Peng , Xie Huifeng , Chen Yushu , Liu Rixu , Zeng Junjie , Bai Bo 
Published: August 2023

Abstract
Background and objective: Maintaining the lower limb in a neutral posture following total knee arthroplasty (TKA) has long been a concept maintained by operators. This study aimed to investigate the relationship between changes in lower limb alignment and the dynamics of knee gait before and after TKA to understand the impact of alignment on gait better and offer a theoretical foundation for correcting lower limb alignment in TKA.
Methods: Our study included a group of 20 participants. The cohort consisted of 1 male and 19 females, 11 left and 9 right knees, ages 58 to 81. Following that, we investigated the association between the HKA angle before and after surgery, as well as the kinematic gait of the knee.
Results: For preoperative HKA angles ranging from -28° to -3°, we observed increased step length, flexion-extension rotation, and varus-valgus rotation with an increase in HKA angle. Conversely, an increase in HKA angle from -3° to 15° corresponded with decreased step length, flexion-extension rotation, and varus-valgus rotation. An increase in HKA angle from 1° to 3° postoperatively increased step length, flexion-extension rotation, and varus-valgus rotation. In contrast, increasing the HKA angle from 3° to 5° resulted in less flexion-extension rotation. The flexion-extension rotation was at its maximum when the HKA angle was 3°. A 3° postoperative varus resulted in improved kinematic gait. Step length, varus-valgus rotation, and flexion-extension rotation increased with increasing HKA angle in the neutral alignment group. In contrast, the non-neutral alignment group exhibited decreased flexion-extension rotation as the HKA angle increased, while step length and varus-valgus rotation increased as the HKA angle increased. The varus-valgus rotation was statistically significant (p<0.05) in the preoperative versus early postoperative period in the 6 degrees of freedom. Conclusions: A 3° varus alignment was found to have a superior postoperative knee kinematic gait, implying that a 3° varus alignment may be more suitable as a new gold standard for TKA than the traditional "0°" alignment. The neutral alignment group demonstrated a better knee kinematic gait than the non-neutral alignment group. During early postoperative walking, significant improvements in varus-valgus rotation were found in the 6 degrees of knee freedom.
REMOVAL OF RHODAMINE B AND METHYLENE BLUE USING RESIDUAL Onecarpus bacabaMart FIBERS AS BIOSORBENT: KINETIC AND THERMODYNAMIC PARAMETERS
Authors: Rolim Eberlanny Moraes , Silva Andreza Miranda Barata da , Batista Joel dos Santos , Serrão Naiany Oliveira , Oliver Leticia Layer , de Freitas Flávio Augusto , Perotti Gustavo Frigi , Carmo Dominique Fernandes de Moura do , Celestino Gustavo Gusmão , Maia Paulo José Sousa 
Published: August 2023

Abstract
Among the most common water contaminants, dyes are responsible for polluting rivers and other water bodies as well as contributing to other environmental problems, thus posing serious health hazards to humans and animals. In order to minimize these environmental impacts, this study proposes the use of Onecarpus bacaba Mart fiber residues, in natura (OBMi) and NaOH-modified (OBMm), to bioadsorb rhodamine b (RhB) and methylene blue (MB) dyes. The biosorbents OBMi and OBMm were characterized by means of infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, Boehm titration, PZC, and scanning electron microscopy. This study also analyzed the influence of pH, contact time, absorbent mass, temperature, and contaminant concentrations by means of batch equilibrium assays. Maximum OBMm adsorption capacity for RhB and MB at 25°C was 26.60 mg g− 1 and 407.98 mg g− 1, respectively. In both systems, OBMm:RhB and OBMm:MB, adsorption kinetics followed a pseudo-second-order law, and the Langmuir and Freundlich models constituted the best fit for isothermal curves. Lastly, thermodynamic parameters indicated that adsorption of both RhB and MB onto OBMm is spontaneous.
Higher-order topological asymptotic formula for the elasticity operator and application
Authors: Barhoumi Montassar 
Published: August 2023

Abstract
This paper is concerned with a geometric inverse problem related to the elasticity equation. We aim to identify an unknown hole from boundary measurements of the displacement field. The Kohn-Vogelius concept is employed for formulating the inverse problem as a topology optimization one. We develop a topological sensitivity analysis based method for detecting the location, size and shape of the unknown hole. We derive a higher-order asymptotic formula describing the variation of a Kohn-Vogelius type functional with respect to the creation of an arbitrary shaped hole inside the computational domain.
Bistability and nonequilibrium condensation in a driven-dissipative Josephson array: A c-field model
Authors: Reeves Matt , Davis Matthew 
Published: August 2023

Developing theoretical models for nonequilibrium quantum systems poses significant challenges. Here we develop and study a multimode model of a driven-dissipative Josephson junction chain of atomic Bose-Einstein condensates, as realised in the experiment of Labouvie et al. [Phys. Rev. Lett. 116, 235302 (2016)]. The model is based on c-field theory, a beyond-mean-field approach to Bose-Einstein condensates that incorporates fluctuations due to finite temperature and dissipation. We find the c-field model is capable of capturing all key features of the nonequilibrium phase diagram, including bistability and a critical slowing down in the lower branch of the bistable region. Our model is closely related to the so-called Lugiato-Lefever equation, and thus establishes new connections between nonequilibrium dynamics of ultracold atoms with nonlinear optics, exciton-polariton superfluids, and driven damped sine-Gordon systems.
Long-term oxygen therapy for chronic obstructive pulmonary disease: results from an observational cohort study
Authors: Nuralieva G. S. , Shmidt A. E. , Nekludova G. V. , Gaynitdinova V. V. , Tsareva N. A. , Chikina S. Yu. , Merzhoeva Z. M. , Trushenko N. V. , Karchevskaya N. A. , Avdeev I. S. , Tkachenko V. V. , Krokhin K. A. , Avdeev S. N. 
Published: August 2023

Introduction. Chronic obstructive pulmonary disease (COPD) is a disease characterized by the persistent restriction of airflow and is a consequence of chronic inflammation of the respiratory tract and lung tissue in response to exposure to inhaled damaging particles or gases. The high prevalence of chronic obstructive pulmonary disease and the high risk of mortality among patients has long been an important problem of the modern healthcare. One of the most severe complications of COPD is chronic respiratory failure. The use of oxygen in patients with chronic hypoxemia should be constant, prolonged and as usually carried out at home; therefore, this form of therapy is called long-term oxygen therapy (LTOT).Aim. To determine the effect of the use of LTOT on survival in patients with COPD and chronic respiratory failure.Materials and methods. 324 patients were retrospectively included in the study. They were hospitalized in the period from 2011 to 2017 with a confirmed diagnosis of COPD with FEV1 31,6% predicted used LTOT. Clinical data were obtained from patient medical histories. The control group (patients with COPD who did not receive LTOT) was also compiled based on retrospective data.Results. The 5-year survival rate of patients with COPD treated with LTOT was 54.6 (95% CI 49.3–60.4) % (a total of 324 people, 177 of them died, 138 survived, 9 people were censored), in the control group – 34.7 (95% CI 30.6–39.3) % (482 in total people, 298 of them died, 166 survived, 18 censored) (р < 0.001).Conclusions. The use of LTOT has a significantly positive effect on the survival of patients with COPD.
Paresis of the larynx after operations on the thyroid gland in an oncological clinic and methodological aspects of its relief
Authors: Novozhilova E. N. , Popadyuk V. I. , Bukanova N. Yu. , Chernolev A. I. , Kirichenko I. M. 
Published: August 2023

Introduction. Paresis and paralysis of the larynx are a fairly common complication after thyroid surgery and are found in all clinics (oncology and endocrinology). The frequency of this complication according to the literature ranges from 4 to 35%. The risk of damage to the recurrent nerve increases especially during repeated operations on the thyroid gland. According to the literature, postoperative transient and persistent paresis of the larynx is distinguished.Aim. To evaluate objective data on the larynx state in the postoperative period, estimate the time required for reversal of laryngeal paresis, and develop a laryngeal function recovery complex for the postoperative period.Materials and methods. We analyzed data on 628 patients treated at the clinic in the department of head and neck tumors in 2020–2021. The study included 47 patients (7.2%) who met the selected criteria. Among them were 40 women and 7 men. The average age is 51 years (43–60 years). The duration of the disease averaged 62 months (24–102). In 38 patients, papillary cancer was detected, in 1 – medullary, in 8 – follicular tumors of a benign nature.Results of the study. Early detection of laryngeal paresis occurred in 42 patients. In 52% (24 patients), postoperative hypocalcemia was detected, which was stopped on the background of drug administration. In 3 patients, fold mobility remained on days 1–2 after surgery, and paresis appeared on days 4–5. Speech therapy work includes a phased set of activities: 1) rational psychotherapy; 2) work on the normalization of physiological and phonation respiration; 3) phonopedic exercises; 4) in the presence of dysphagia, work is carried out to restore the function of swallowing.Conclusions. The development of postoperative paresis of the larynx is possible even if the integrity of the recurrent nerves is preserved; the use of the technique of microsurgical neurolysis can significantly reduce the frequency of paresis of the larynx; with transient paresis, most often mobility is restored after 1-3 months; the use of an integrated approach to the rehabilitation of this category of patients allows to achieve improved functional results; with bilateral persistent paralysis of the larynx, as an alternative to tracheostomy, the chordotomy technique using a CO2 laser can be used.