bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroprotection or Sex Bias: A Protective Response to Traumatic Brain
Injury in the Females
Authors: Yatoo Mohammad I. , Bahader Ghaith A. , Beigh Shafayat A. , Khan Adil M. , James Antonisamy William , Asmi Maleha R. , Shah Zahoor A. 
Published: August 2023

Abstract:
Traumatic brain injury (TBI) is a major healthcare problem and a common cause of mortality
and morbidity. Clinical and preclinical research suggests sex-related differences in short- and longterm
outcomes following TBI; however, males have been the main focus of TBI research. Females
show a protective response against TBI. Female animals in preclinical studies and women in clinical
trials have shown comparatively better outcomes against mild, moderate, or severe TBI. This reflects a
favorable protective nature of the females compared to the males, primarily attributed to various protective
mechanisms that provide better prognosis and recovery in the females after TBI. Understanding
the sex difference in the TBI pathophysiology and the underlying mechanisms remains an elusive
goal. In this review, we provide insights into various mechanisms related to the anatomical, physiological,
hormonal, enzymatic, inflammatory, oxidative, genetic, or mitochondrial basis that support the
protective nature of females compared to males. Furthermore, we sought to outline the evidence of
multiple biomarkers that are highly potential in the investigation of TBI's prognosis, pathophysiology,
and treatment and which can serve as objective measures and novel targets for individualized therapeutic
interventions in TBI treatment. Implementations from this review are important for the understanding
of the effect of sex on TBI outcomes and possible mechanisms behind the favorable response
in females. It also emphasizes the critical need to include females as a biological variable and in sufficient
numbers in future TBI studies.
Apelin Receptor Dimerization and Oligomerization
Authors: Yeganeh-Hajahmadi Mahboobeh , Moosavi-Saeed Yasmin , Rostamzadeh Farzaneh 
Published: August 2023

Abstract:
Apelin and its receptor are expressed in many tissues and play an important role in maintaining the homeostasis of the cardiovascular system and body fluids. Also, the association of this system with many diseases, such as diabetes, hypertension, obesity, cancer, diabetic retinopathy, etc., has been determined. This system is considered a therapeutic goal in many mentioned diseases. G protein-coupled receptors (GPCRs) have the ability to form oligomers and dimers with themselves and other receptors. The formation of these oligomers is associated with a change in the signaling pathways of the receptors. Research on the oligo and dimers of these receptors can revolutionize the principles of pharmacology. The apelin receptor (APJ) is also a GPCR and has been shown to have the ability to form dimers and oligomers. This article discusses the dimerization and oligomerization of this receptor with its own receptor and other receptors, as well as the signaling pathways.
Nanotechnology-based Drug Delivery of Topical Antifungal Agents
Authors: Singh Sumita , Patil Vaishali M. , Paliwal Sarvesh Kumar , Masand Neeraj 
Published: August 2023

Abstract:
Among the various prominent fungal infections, superficial ones are widespread. A large
number of antifungal agents and their formulations for topical use are commercially available. They
have some pharmacokinetic limitations which cannot be retracted by conventional delivery systems.
While nanoformulations composed of lipidic and polymeric nanoparticles have the potential to overcome
the limitations of conventional systems. The broad spectrum category of antifungals i.e. azoles
(ketoconazole, voriconazole, econazole, miconazole, etc.) nanoparticles have been designed, prepared
and their pharmacokinetic and pharmacodynamic profile was established. This review briefly
elaborates on the types of nano-based topical drug delivery systems and portrays their advantages for
researchers in the related field to benefit the available antifungal therapeutics.
Insight into the Nutraceutical Potential of Garcinia Species
Authors: Karmakar Shreyasi , Gogoi Urvashee , Saikia Riya , Das Aparoop 
Published: August 2023

Background::A wide variety of Garcinia species have been used over decades, as traditional home remedies starting from their use in flavored food to the treatment of various ailments. The presence of the essential primary and secondary metabolite with curative properties in Garcinia has enhanced its value in the therapeutic world. These have captivated the use of Garcinia in expanding nutritional values and adding extra health benefits. Hereby, observing the potential of different Garcinia species for their use as nutraceuticals.Objective::The present-day lifestyle and current health trends are the reasons why the public has accumulated a lot of interest in the nutraceutical food market. Traditionally the various remedies used from plants, fruits, and fruit extracts used in the cure of multiple ailments since antiquity have now made their way into pharmaceutical nutraceuticals. The fruits of Garcinia species have many culinary, nutritional, and pharmaceutical uses. Therefore, the paper aims to focus on the different Garcinia species having nutritional potential along with various therapeutic properties.Methods::Studies of different Garcinia species are reviewed, with a focus on their nutritional and medicinal actions on ailments that are the reason for today's lifestyles and current health trends.Results::Different varieties of Garcinia species are found to have various potential primary and secondary metabolites which have curative properties like anti-diabetic, anti-obesity, anti-microbial, anti-cancer, anti-inflammation, and anti-bacterial potential.Conclusion::The natural occurrences of the plant product with nutraceutical value have boosted the quality of life. The Garcinia species containing the essential primary and secondary constituents are accountable for numerous biological activities. Many of the Garcinia species are marketed these days for a better and healthy life. Thus, Garcinia could be used as a nutraceutical to alleviate several disease conditions.
An Improved Voltage Sag Monitor Placement Method by using Simple
Probability Reach Area Matrix
Authors: Zhong Zhenfang , Meng Qingwei , Gao Han , Chen Dong , Jia Zhiheng , Hou Yue 
Published: August 2023

Aim:
A novel optimization model is introduced in this paper to achieve monitor placements
of voltage sag.

Background:
Considering the uncertainty of system parameters, calculation errors and measurement
errors, the method of MRA is not suitable.

Objective:
The contradiction between the number of monitors and observation areas can be coordinated
to achieve voltage sag observation with fewer monitor quantities.

Method:
A new generalized approach defined as a simple probability reach area matrix (SPMRA)
is proposed.

Result:
SPMRA method is simulated by the IEEE-39 bus system, which reveals that monitor
placement quantities can be reduced effectively under probabilistic observability.

Conclusion:
SPMRA method is a general method for monitor placements of voltage sag. This
method not only performs the functions of conventional MRA methods, but also addresses the
challenges of errors and conflicts between observation requirements and installation costs.
Investigating and Improving the Efficiency of Space-time Codes in Visible
light Communication Systems based on a Multi-input-multi-output
Channel Model
Authors: Heidari Mahdieh , Akbari Mahdi , Olyaee Saeed 
Published: August 2023

Background:
Visible light communication (VLC) is a new communication method for
transmitting information through semiconductor lighting devices. One of the applicable methods to
improve the spectral efficiency of the system is the multi-input-multiple-output (MIMO) structure.
Also, carrierless amplitude-phase (CAP) modulation is a high-dimensional modulation technique
that can be used to improve the data transmission rate in modern communication systems.

Methods:
In this paper, carrierless amplitude-phase method is introduced in indoor optical communication
systems to improve the performance of multi-input multi-output (MIMO) structures.
The CAP modulation is considered a suitable method due to its low complexity and is introduced
and studied in two structures with one carrier or CAP and multiple carriers or m-CAP.

Results:
In this study, the target system is simulated in m-CAP structures and the improvement is
measured in the MIMO structure using this modulation. The results show that by using this method,
the PAPR of the system was reduced compared to other research with the MIMO-OFDM structure.
In addition, by not using FFT blocks, the computational and processing complexity was also
reduced.

Conclusion:
It has been shown that the use of m-CAP increases the data transfer rate and improves
the spectral efficiency of the system. In addition to CAP, spatial modulation schemes can also help
improve the spectral efficiency and power efficiency of the system. Moreover, the space-time code
is combined with m-CAP modulation and it is shown that this idea improves the efficiency of the
MIMO system.
Formulation Design and Characterization of Nilotinib Polymeric Nanoparticles
by Nanoprecipitation Technique for the Improved Drug Solubility
and Dissolution Rate
Authors: Tamminana Mallika , Ravi Kumar Bera Venkata Varaha 
Published: August 2023

Introduction:
Nilotinib is a BCS class-IV poorly water-soluble kinase inhibitor drug, that
was used for this study to prepare the polymeric nanoparticles by nanoprecipitation technique using
Eudragit RL-100 and RS-100 as polymers, Killophore P-188 as a surfactant, and PEG 400 used as a
non-volatile, and nontoxic solvent for the improvement of the drug solubility and dissolution rate.

Method:
The initial process and formulation variables are screened out based on the selected critical
quality attributes such as drug release (%), particle size (nm), zeta potential (mV), and polydispersity
index. The FT-IR and DSC studies reveal that the drug has no compatibility between the selected drug
and the polymers and does not show any additional drug peaks after physical mixing and formulations.
The prepared nanoparticles were further characterized to evaluate the particle size (nm), polydispersity
index (PDI), zeta potential (mV), entrapment efficiency (%), and in-vitro drug release (%). From the
in vitro drug release study, Eudragit RL-100 and Killophore P-188-based formulations showed optimum
drug entrapment efficiency with improved drug solubility and dissolution rate in PEG 400 compared
to Eudragit RS-100-based formulations. The accelerated stability data for the optimized formulation
batch (F6) before and after storage conditions at 40±2 0C and 75±5% RH indicates that the optimized
formulation (F6) is more stable for up to 6 months without changes in drug entrapment efficiency
and in vitro dissolution rate. Dissolution kinetic data and diffusion exponent values suggested
that optimized formulation followed the Higuchi model with a non-Fickian transport mechanism.

Result:
According to the results, the preparation method proposed in this study is the most suitable
for generating polymeric nanoparticles of nilotinib for improved drug solubility and dissolution rate.

Conclusion:
The nilotinib-based polymeric nano-formulation proved a potential alternative for better
drug release with an enhanced solubility rate.
Bifidobacterial Postbiotics as Health-promoting Agents in Dairy Products
Authors: Homayouni-Rad Aziz , Moghadam Saba Kamalledin , Mortazavian Amir M. , Abachi Soheila , Allahmadadi Sevda 
Published: August 2023

Background:
Bifidobacteria is a commercial probiotic that is widely used in industries. However, due to its oxygen-sensitive nature, industries have faced some limitations during the addition of the products. Recently it was stated that the metabolites secreted by bifidobacteria have a key role in improving health.

Objective:
The possibility of a postbiotic replacement for probiotics in dairy industries and its effect on health are discussed.

Method:
the keywords including postbiotic, probiotic, dairy, bifidobacteria, inactivated bifidobacteria, bifidobacteria metabolites, the effect of bifidobacteria on psychology, human health, cancer, and inflammation are searched on Google Scholar as well as more than 600 research and review articles are read.

Result:
Bifidobacteria could change gut bacteria positively and improve health directly. Also, the metabolites produced by bifidobacteria indirectly have wide-range effects on health.

Conclusion:
Due to the anaerobic nature of bifidobacteria, applying a postbiotic / non-viable form of bifidobacteria is a sagacious option in dairy products.
Short-Form Video Exposure and Its Two-Sided Effect on the Physical Activity of Older Community Women in China: Secondary Data Analysis
Authors: Wu Chen , Chen Si , Wang Shan , Peng Sijing , Cao Jiepin 
Published: August 2023

Abstract

Background
There is a tendency for older adults to become more physically inactive, especially older women. Physical inactivity has been exacerbated since the COVID-19 pandemic. Lockdowns and information-based preventive measures for COVID-19 increased the number of short-form video app users and short-form video exposure, including content exposure and the duration of exposure, which has demonstrated important effects on youths’ health and health-related behaviors. Despite more older adults viewing short-form videos, less is known about the status of their short-form video exposure or the impacts of the exposure on their physical activity.

Objective
This study aims to describe physical activity–related content exposure among older adults and to quantify its impacts along with the duration of short-form video exposure on step counts, low-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA).

Methods
We analyzed a subsample (N=476) of older women who used smartphones and installed short-form video apps, using the baseline data collected from an ongoing cohort study named the Physical Activity and Health in Older Women Study (PAHIOWS) launched from March to June 2021 in Yantai, Shandong Province, China. The information on short-form video exposure was collected by unstructured questions; physical activity–related content exposure was finalized by professionals using the Q-methodology, and the duration of exposure was transformed into hours per day. Step counts, LPA, and MVPA were assessed with ActiGraph wGT3X-BT accelerometers. Multiple subjective and objective covariates were assessed. Linear regression models were used to test the effects of short-form video exposure on step counts, LPA, and MVPA. MVPA was dichotomized into less than 150 minutes per week and 150 minutes or more per week, and the binary logistic regression model was run to test the effects of short-form video exposure on the achievement of spending 150 minutes or more on MVPA.

Results
Of 476 older women (mean age 64.63, SD 2.90 years), 23.7% (113/476) were exposed to physical activity–related short-form videos, and their daily exposure to short-form videos was 1.5 hours. Physical activity–related content exposure increased the minutes spent on MVPA by older women (B=4.14, 95% CI 0.13-8.15); the longer duration of short-form video exposure was associated with a reduced step count (B=−322.58, 95% CI −500.24 to −144.92) and minutes engaged in LPA (B=−6.95, 95% CI −12.19 to −1.71) and MVPA (B=−1.56, 95% CI −2.82 to −0.29). Neither content exposure nor the duration of exposure significantly increased or decreased the odds of older women engaging in MVPA for 150 minutes or more per week.

Conclusions
Short-form video exposure has both positive and negative impacts on the physical activity of older adults. Efforts are needed to develop strategies to leverage the benefits while avoiding the harms of short-form videos.
Determinants of Patient Use and Satisfaction With Synchronous Telemental Health Services During the COVID-19 Pandemic: Systematic Review
Authors: Neumann Ariana , König Hans-Helmut , Bokermann Josephine , Hajek André 
Published: August 2023

Background
Several recent studies examined patient use and satisfaction with synchronous telemental health services in response to the widespread implementation during the COVID-19 pandemic. However, a systematic review of recent literature on the determinants of these outcomes is missing.

Objective
The aim of this systematic review was to give an extensive overview of the literature on and highlight the influential determinants of patient use and satisfaction with synchronous telemental health services during the COVID-19 pandemic.

Methods
This review satisfied the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and was registered in PROSPERO. Peer-reviewed, quantitative studies that observed the determinants of patient use or satisfaction with synchronous telemental health services during the COVID-19 pandemic were included. PubMed, PsycInfo, and Web of Science database searches were conducted in August 2022 for English and German language studies published from 2020 onward. Key steps were performed by 2 reviewers. Determinants were synthesized into major categories informed by the dimensions of the widely used and established Unified Theory of Acceptance and Use of Technology.

Results
Of the 20 included studies, 10 studies examined determinants of patient use, 7 examined determinants of patient satisfaction, and 3 observed both outcomes. The quality of the studies was mainly good or fair. There was substantial heterogeneity in the study designs, methods, and findings. Sociodemographic characteristics and health-related determinants were mostly considered. Some of the major dimensions of the Unified Theory of Acceptance and Use of Technology were neglected in recent studies. Although most findings were mixed or nonsignificant, some indications for potential relationships were found (eg, for sex, age, and symptom severity).

Conclusions
The findings revealed potential target groups (eg, female and young patients with mild symptoms) for future postpandemic telemental health interventions. However, they also identified patient groups that were harder to reach (eg, older patients with severe symptoms); efforts may be beneficial to address such groups. Future quantitative and qualitative research is needed to secure and expand on recent findings, which could help improve services.

Trial Registration
PROSPERO CRD42022351576; https://tinyurl.com/yr6zrva5
Perceived Patient Workload and Its Impact on Outcomes During New Cancer Patient Visits: Analysis of a Convenience Sample
Authors: Elkefi Safa , Asan Onur 
Published: August 2023

Background
Studies exploring the workload in health care focus on the doctors’ perspectives. The ecology of the health care environment is critical and different for doctors and patients.

Objective
In this study, we explore the patient workload among newly diagnosed patients with cancer during their first visit and its impact on the patient’s perceptions of the quality of care (their trust in their doctors, their satisfaction with the care visits, their perception of technology use).

Methods
We collected data from the Hackensack Meridian Health, John Theurer Cancer Center between February 2021 and May 2022. The technology use considered during the visit is related to doctors’ use of electronic health records. A total of 135 participants were included in the study. Most participants were 50-64 years old (n=91, 67.41%). A majority (n=81, 60%) of them were White, and only (n=16, 11.85%) went to graduate schools.

Results
The findings captured the significant effect of overall workload on trust in doctors and perception of health IT use within the visits. On the other hand, the overall workload did not impact patients’ satisfaction during the visit. A total of 80% (n=108) of patients experienced an overall high level of workload. Despite almost 55% (n=75) of them experiencing a high mental load, 71.1% (n=96) reported low levels of effort, 89% (n=120) experienced low time pressure, 85.2% (n=115) experienced low frustration levels, and 69.6% (n=94) experienced low physical activity. The more overall workload patients felt, the less they trusted their doctors (odds ratio [OR] 0.059, 95% CI 0.001-2.34; P=.007). Low trust was also associated with the demanding mental tasks in the visits (OR 0.055, 95% CI 0.002-2.64; P<.001), the physical load (OR 0.194, 95% CI 0.004-4.23; P<.001), the time load (OR 0.183, 95% CI 0.02-2.35; P=.046) the effort needed to cope with the environment (OR 0.163, 95% CI 0.05-1.69; P<.001), and the frustration levels (OR 0.323, 95% CI 0.04-2.55; P=.03). The patients’ perceptions of electronic health record use during the visit were negatively impacted by the overall workload experienced by the patients (OR 0.315, 95% CI 0.08-6.35; P=.01) and the high frustration level experienced (OR 0.111, 95% CI 0.015-3.75; P<.001).

Conclusions
The study’s findings established pathways for future research and have implications for cancer patients’ workload. Better technology design and use can minimize perceived workload, which might contribute to the trust relationship between doctors and patients in this critical environment. Future human factors work needs to explore the workload and driving factors in longitudinal studies and assess whether these workloads might contribute to unintended patient outcomes and medical errors.
Strengthening Mental Health and Resilience Through Schools: Protocol for a Participatory Design Project
Authors: Kegelaers Jolan , Baetens Imke , Soyez Veerle , Van Heel Martijn , Van Hove Lisa , Wylleman Paul 
Published: August 2023

Background
Mental health problems are a main contributor to the global burden of disease in children and young people within urban environments. In response, the potential of both school- and sport-based mental health promotion interventions has been advocated. However, there exists limited insights into how sport-based interventions can be integrated within school environment. Moreover, there is a need to consider children and young people’s specific needs, challenges, and motivations when designing novel mental health promotion interventions.

Objective
The Strengthening Mental Health and Resilience Through Schools (SMARTS) project aims to co-design an evidence-informed school-sport-based mental health promotion program. Specific objectives include (1) co-designing a multicomponent program, integrating sport sessions with class-based sessions, and complementing with educational modules for teachers and parents; (2) exploring how the mental health program can be implemented most effectively within the Brussels school system; and (3) conducting preliminary process and outcome testing of the program.

Methods
A participatory design framework will be adopted to develop the program. This framework involves end users throughout the entire study process, from problem identification to intervention delivery and evaluation, while at the same time ensuring program development remains directly informed by the available scientific evidence.

Results
Participant recruitment will commence in September 2023. The full project will be completed by March 2027.

Conclusions
With this intervention, we aim to provide a direct contribution to the promotion of children and young people’s mental health within the Brussels school context. At a broader level, conducting and documenting this large participatory design project can, hopefully, inspire other researchers to tailor their mental health programs to specific populations.

International Registered Report Identifier (IRRID)
PRR1-10.2196/49670