bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visco‐Elastic Parameters at Three‐Dimensional MR Elastography for Diagnosing Non‐Alcoholic Steatohepatitis and Substantial Fibrosis in Mice
Authors: Khalfallah Meryem , Doblas Sabrina , Hammoutene Adel , Julea Felicia , Postic Catherine , Valla Dominique , Paradis Valérie , Garteiser Philippe , Van Beers Bernard E. 
Published: May 2023

BackgroundNonalcoholic fatty liver disease (NAFLD) is increasing worldwide and is a growing cause of liver cirrhosis and cancer. The performance of the magnetic resonance elastography (MRE) visco‐elastic parameters in diagnosing progressive forms of NAFLD, including nonalcoholic steatohepatitis (NASH) and substantial fibrosis (F ≥ 2), needs to be clarified.PurposeTo assess the value of three‐dimensional MRE visco‐elastic parameters as markers of NASH and substantial fibrosis in mice with NAFLD.Study TypeProspective.Animal ModelTwo mouse models of NAFLD were induced by feeding with high fat diet or high fat, choline‐deficient, amino acid‐defined diet.Field Strength/Sequence7T/multi‐slice multi‐echo spin‐echo MRE at 400 Hz with motion encoding in the three spatial directions.AssessmentHepatic storage and loss moduli were calculated. Histological analysis was based on the NASH Clinical Research Network criteria.Statistical TestsMann–Whitney, Kruskal–Wallis tests, Spearman rank correlations and multiple regressions were used. Diagnostic performance was assessed with areas under the receiver operating characteristic curves (AUCs). P value <0.05 was considered significant.ResultsAmong the 59 mice with NAFLD, 21 had NASH and 20 had substantial fibrosis (including 8 mice without and 12 mice with NASH). The storage and loss moduli had similar moderate accuracy for diagnosing NASH with AUCs of 0.67 and 0.66, respectively. For diagnosing substantial fibrosis, the AUC of the storage modulus was 0.73 and the AUC of the loss modulus was 0.81, indicating good diagnostic performance. Using Spearman correlations, histological fibrosis, inflammation and steatosis, but not ballooning, were significantly correlated with the visco‐elastic parameters. Using multiple regression, fibrosis was the only histological feature independently associated with the visco‐elastic parameters.ConclusionMRE in mice with NAFLD suggests that the storage and loss moduli have good diagnostic performance for detecting progressive NAFLD defined as substantial fibrosis rather than NASH.Evidence Level1Technical Efficacy Stage2
Initial insight into three modes of data sharing: Prevalence of primary reuse, data integration and dataset release in research articles
Authors: Sakai Yukiko , Miyata Yosuke , Yokoi Keiko , Wang Yuqing , Kurata Keiko 
Published: May 2023

AbstractWhile data sharing has received research interest in recent times, its real status remains unclear, owing to its ambiguous concept. To understand the current status of data sharing, this study examined primary reuse, data integration, and dataset release as the actual practices of data sharing. A total of 963 articles, chosen from those published in 2018 and registered in the Web of Science global citation database, were manually checked. Existing data were reused in the mode of data integration (13.3%) as frequently as they were for the mode of primary reuse (12.1%). Dataset release was the least common mode (9.0%). The results show the variation in data sharing and indicate the need for standardization of data description in articles based on thorough registration and expansion in public data archives to close the loop that results in the virtuous cycle of research data.
Immunogenic Potential and Therapeutic Efficacy of Multi‐Epitope Encapsulated Silk Fibroin Nanoparticles against Pseudomonas aeruginosa‐Mediated Urinary Tract Infections
Authors: Rezvanirad Azam , Habibi Mehri , Farokhi Mehdi , Asadi Karam Mohammad Reza 
Published: May 2023

AbstractPseudomonas aeruginosa (P. aeruginosa) causing urinary tract infections (UTIs) are a major concern among hospital‐acquired infections. The need for an effective vaccine that reduces the infections is imperative. This study aims to evaluate the efficacy of a multi‐epitope vaccine encapsulated in silk fibroin nanoparticles (SFNPs) against P. aeruginosa‐mediated UTIs. A multi‐epitope is constructed from nine proteins of P. aeruginosa using immunoinformatic analysis, expressed, and purified in BL21 (DE3) cells. The encapsulation efficiency of the multi‐epitope in SFNPs is 85% with a mean particle size of 130 nm and 24% of the encapsulated antigen is released after 35 days. The vaccine formulations adjuvanted with SFNPs or alum significantly improve systemic and mucosal humoral responses and the cytokine profile (IFN‐γ, IL‐4, and IL‐17) in mice. Additionally, the longevity of the IgG response is maintained for at least 110 days in a steady state. In a bladder challenge, mice treated with the multi‐epitope admixed with alum or encapsulated in SFNPs demonstrate significant protection of the bladder and kidneys against P. aeruginosa. This study highlights the promising therapeutic potential of a multi‐epitope vaccine encapsulated in SFNPs or adjuvanted with alum against P. aeruginosa infections.
Exploring mental time travel experiences and their influence on behavioral intentions and learning
Authors: Barhorst Jennifer Brannon , Krey Nina , McLean Graeme 
Published: May 2023

AbstractDrawing on cognitive science research, this study presents mental time travel experiences to the marketing literature and explores their value to brands. Specifically, we examine how marketing stimuli can be used to elicit mental time travel experiences and the impact these experiences have on important brand outcomes including purchase intentions, word of mouth, loyalty intentions, and learning. We do so with two studies using branded experiences from two marketing campaigns across four different conditions: augmented reality, a 360° website, a video, and a static image. Results identify positive episodic memories as an important primer of mental time travel experiences and that mental time travel to the past is a key factor to influencing purchase intentions, word of mouth, loyalty intentions, and learning. We also show that cognitive load can have an inhibiting effect on mental time travel's ability to influence purchase intentions, word of mouth, and loyalty intentions. Finally, we demonstrate that a state of immersion can enhance mental time travel's ability to influence learning.
Motion‐compensated low‐rank reconstruction for simultaneous structural and functional UTE lung MRI
Authors: Tan Fei , Zhu Xucheng , Chan Marilynn , Zapala Matthew A. , Vasanawala Shreyas S. , Ong Frank , Lustig Michael , Larson Peder E. Z. 
Published: May 2023

PurposeThree‐dimensional UTE MRI has shown the ability to provide simultaneous structural and functional lung imaging, but it is limited by respiratory motion and relatively low lung parenchyma SNR. The purpose of this paper is to improve this imaging by using a respiratory phase‐resolved reconstruction approach, named motion‐compensated low‐rank reconstruction (MoCoLoR), which directly incorporates motion compensation into a low‐rank constrained reconstruction model for highly efficient use of the acquired data.Theory and MethodsThe MoCoLoR reconstruction is formulated as an optimization problem that includes a low‐rank constraint using estimated motion fields to reduce the rank, optimizing over both the motion fields and reconstructed images. The proposed reconstruction along with XD and motion state–weighted motion‐compensation (MostMoCo) methods were applied to 18 lung MRI scans of pediatric and young adult patients. The data sets were acquired under free‐breathing and without sedation with 3D radial UTE sequences in approximately 5 min. After reconstruction, they went through ventilation analyses. Performance across reconstruction regularization and motion‐state parameters were also investigated.ResultsThe in vivo experiments results showed that MoCoLoR made efficient use of the data, provided higher apparent SNR compared with state‐of‐the‐art XD reconstruction and MostMoCo reconstructions, and yielded high‐quality respiratory phase‐resolved images for ventilation mapping. The method was effective across the range of patients scanned.ConclusionThe motion‐compensated low‐rank regularized reconstruction approach makes efficient use of acquired data and can improve simultaneous structural and functional lung imaging with 3D‐UTE MRI. It enables the scanning of pediatric patients under free‐breathing and without sedation.
Reinforcing mechanically reclaimed polyurethane foam wastes‐based elastomer with modified recycled polyester fibers
Authors: Duan Ruoxuan , Wei Lingfei , Coates Phil , Kelly Adrian , Wang Chao , Chen Binxia , Zhou Zehang , Lu Canhui 
Published: May 2023

AbstractPolyurethane foams are widely used in daily life due to their superior performance. However, it is very challenging to recycle and reuse waste polyurethane foams since the three‐dimensional crosslinking network structure makes them non‐melting and insoluble. In this work, a low‐cost, green, room‐temperature solid‐state shear milling method is proposed to break the cross‐linking bonds of waste polyurethane foam (crosslinking density decreases from 0.768 to 0.489 mol dm−3). The recycled polyurethane (RPU) powders regain their thermoplastic processability. Recycled waste polyester (PET) fibers are modified through plasma treatment and used as reinforcing fillers for the reprocessed RPU elastomer. Compared to original PET fibers, modified polyester (m‐PET) fibers construct strong interfacial interactions and physical interlocks with RPU matrix, leading to significantly enhanced mechanical properties. Molecular dynamics studies demonstrate that RPU/m‐PET composites have higher cohesive energy density and lower free volume, and significantly improved compatibility, which greatly promotes stress dissipation upon stretching. This study provides a feasible strategy for the high‐value recycling of waste polymer materials.
Multienzyme‐Mimetic Activity of Gold/Cerium Oxide Nanozyme
Authors: Xin Qi , Wang Li , Ruan Haiyan , Liu Ling , Sun Si , Zhang Jing , Wu Menglin , Mu Xiaoyu , Wang Hao , Zhang Shaofang , Zhang Xiao‐Dong 
Published: May 2023

AbstractRedox‐active nanozymes offer low‐cost controlled synthesis, high stability, and tunable catalytic properties over natural enzymes, which have attracted wide attention in the field of disease diagnosis and treatment. However, the improvement of catalytic activity remains an important challenge for nanozymes. Herein, the Au/CeO2 nanozymes is developed to achieve enhanced multiple enzyme‐mimetic activity. The Au/CeO2 nanozymes at 5% doping possess best peroxidase‐like activity with threefold higher catalytic rate than CeO2. For catalase‐mimic catalysis, the Au/CeO2 nanozymes at 5% doping also exhibited a 1.5‐fold enhanced reaction rate higher than pure CeO2. The superoxide dismutase (SOD)‐like capacity of Au/CeO2 nanozymes is proportional to Au content. The Au/CeO2 nanozymes at 10% doping show optimal SOD‐like capacity of 60.2 U mg−1. In vitro experiments validate the regulation ability of intracellular oxidative stress and inflammation. Au/CeO2 nanozymes can reduce lipopolysaccharide‐ or H2O2‐induced oxidative damage by scavenging excess ROS in nerve cell. Therefore, Au/CeO2 can be used as a promising antioxidant in disease treatment, and the study offers general guidelines for achieving enhanced biocatalytic property through atomic doping.
Black Salve (or Escharotics). A Picture About an Unorthodox Medical Preparation in Oncology
Authors: Borkens Yannick 
Published: May 2023

Abstract
Alternative medicine methods and treatments enjoy great popularity. However, many users fail to recognise the dangers associated with these methods. One of these is called Black Ointment or Black Salve. Oncologists and attending physicians should be aware of alternative medical methods such as these and be in a position to provide appropriate advice, intervention, if necessary, at any time when counselling patients in difficult situations.
A facile synthesis and luminescence properties of CeF3:Tb3+ via polyol method
Authors: Yue Dan , Zhang Lisha , Wang Haojie , Liu Deri , Yang Xiaotong , Lu Zhiqiang , Li Mingjia , Li Weidong , Chen Dong , Wang Zhenling 
Published: May 2023

AbstractSugar gourd shaped CeF3:Tb3+ has been successfully synthesized by polyol method. The phase, morphology and fluorescent properties of CeF3:Tb3+ were characterized by X‐ray diffraction (XRD), transmission electron microscopy (TEM), infrared spectroscopy (IR) and photoluminescence (PL) spectra, respectively. It can be seen that the volume changes of giethylene glycol (DEG) and H2O content did not affect the phase structure of CeF3:Tb3+. The emission spectrum of CeF3:Tb3+ shows the characteristic emissions of Tb3+ ion, indicating that an energy transfer from Ce3+ to Tb3+ occurs in CeF3:Tb3+, and the decay time of CeF3:Tb3+ was not affected by the change of DEG content.
Subgroup Membership in GL(2,Z)
Authors: Lohrey Markus 
Published: May 2023

AbstractIt is shown that the subgroup membership problem for a virtually free group can be decided in polynomial time when all group elements are represented by so-called power words, i.e., words of the form $$p_1^{z_1} p_2^{z_2} \cdots p_k^{z_k}$$

p
1

z
1

p
2

z
2

⋯

p
k

z
k

. Here the $$p_i$$

p
i

are explicit words over the generating set of the group and all $$z_i$$

z
i

are binary encoded integers. As a corollary, it follows that the subgroup membership problem for the matrix group $$\textsf{GL}(2,\mathbb {Z})$$

GL
(
2
,
Z
)

can be decided in polynomial time when elements of $$\textsf{GL}(2,\mathbb {Z})$$

GL
(
2
,
Z
)

are represented by matrices with binary encoded integers. For the same input representation, it also shown that one can compute in polynomial time the index of a given finitely generated subgroup of $$\textsf{GL}(2,\mathbb {Z})$$

GL
(
2
,
Z
)

.
Flexible supply meets flexible demand: prosumer impact on strategic hydro operations
Authors: Hassanzadeh Moghimi Farzad , Chen Yihsu , Siddiqui Afzal S. 
Published: May 2023

AbstractAmbitious climate packages promote the integration of variable renewable energy (VRE) and electrification of the economy. For the power sector, such a transformation means the emergence of so-called prosumers, i.e., agents that both consume and produce electricity. Due to their inflexible VRE output and flexible demand, prosumers will potentially add endogenous net sales with seasonal patterns to the power system. With its vast hydro reservoirs and ample transmission capacity, the Nordic region is seemingly well positioned to cope with such intermittent VRE output. However, the increased requirement for flexibility may be leveraged by incumbent producers to manipulate prices. Via a Nash-Cournot model with a representation of the Nordic region’s spatio-temporal features and reservoir volumes, we examine how hydro producers’ ability to manipulate electricity prices through temporal arbitrage is affected by (i) VRE-enabled prosumers and (ii) the latter plus a high CO$$_2$$2price. We find that hydro reservoirs could exploit prosumers’ patterns of net sales to conduct temporal arbitrage more effectively, viz., by targeting periods in which prosumers are net buyers (net sellers) to withhold (to “dump”) water. Meanwhile, a higher CO$$_2$$2price would further enhance hydro reservoirs’ market power because flexible price-taking thermal plants would be unable to ramp up production in order to counter such producers’ strategy to target VRE’s intermittency. Hence, in spite of a flexible demand side to complement additional intermittent VRE output, strategic hydro producers may still exacerbate price manipulation in a future power sector via more tailored exercise of market power.
Population dynamics of the common shrew (Sorex araneus) in Central European forest clearings
Authors: Dokulilová Martina , Krojerová-Prokešová Jarmila , Heroldová Marta , Čepelka Ladislav , Suchomel Josef 
Published: May 2023

AbstractThe population dynamics of shrews (Soricidae) are not well known even though they form an important part of forest ecosystems and represent suitable bioindicators of ecosystem quality. The aim of this study was to evaluate the population dynamics of shrews in mountain and upland forest clearings in four study areas within the Czech Republic and to reveal how climatic factors influenced fluctuations in their abundance for a decade (2007–2017). In total, we trapped 7,538 individuals of 18 small mammal species. From 760 individuals of seven shrew species, the common shrew (Sorex araneus) was significantly dominated in all study areas. We did not observe any significant, regular multi-annual cycles of the common shrew. However, a cross-correlation in density fluctuation of this species was detected in all mountain areas indicating the influence of environmental factors acting on a larger geographical scale. The autumn abundance of shrews was dependent on the subset of climatic variables, together explaining 56% of the variance in the linear regression model. Except for the length of the snow cover of ≥ 5 cm, all other significant variables were associated with North Atlantic Oscillation (NAO). Longer duration of snow cover during the winter before trapping, higher average NAO value during months before trapping, and NAO value in September influenced negatively the autumn abundance of shrews, contrary, higher value of NAO in May and October increased the abundance. Our results demonstrate the sensitivity of shrews to winters with a longer period of snow cover and to climatic oscillations associated with the NAO, whose effect is monthly dependent and probably indirectly influencing shrews through their prey.
Efficacy of Cognitive Behavioral Therapy on Academic Stress Among Rural Community Secondary School Economics Students: A Randomized Controlled Evaluation
Authors: Eneogu Njideka D. , Ugwuanyi Chiamaka K. , Ugwuanyi Christian S. 
Published: May 2023

AbstractThis study evaluated the effect of cognitive behavioral therapy (CBT) on the academic stress of rural community secondary school economic students. The study adopted the pre-test, post-test randomized control trial experimental design. The economics academic stress questionnaire (EASQ) was used for data collection using 168 secondary school economics students sampled from rural community schools in Southeast Nigeria. The instrument was validated by three experts in the area of the study and the internal consistency reliability index of the items was estimated as 0.83 using the Cronbach Alpha method. A pre-treatment assessment (pre-test) was conducted using the EASQ to collect baseline data. After that, the experimental group was exposed to 60 min of the CBT program once a week for 8 weeks. The data collected were analysed using mixed-design repeated analysis of variance. The findings of the study revealed that CBT had a significant effect on the management of academic stress among rural community secondary schools economics students. Based on the findings of the study, it can be concluded that the use of CBT intervention will be helpful in the management of academic stress among rural community secondary school economics students. The implication of that is that CBT intervention is effective in the reduction of psychological problems and discomfort among students in order to improve their academic achievement.
Structural and thermal characteristics of Ge30−xSbxTe10Se60 (0 ≤ x ≤ 20) glasses for electronic devices
Authors: Soraya M. M. , Abdel-Wahab Fouad , Elamin A. A. , Shaaban E. R. , Ali Karrar N. N. 
Published: May 2023

AbstractThermal characterization of different compositions of Ge30−xSbxTe10Se60 (x = 0, 5, 10, 15, 20 at.%) glassy materials has been investigated through differential scanning calorimetry (DSC). The tested glasses have been synthesized by melt-quench technique. Glassy materials display compositional phase separation at x = 0, 5, 10, 15 at.%. For additional increase in Sb content at x = 20 at.%, the separation of phases combines in the glass matrix. The glass transition temperature (Tg), initial temperature of crystallization (Tc), peak crystallization temperature (Tp) and melting temperature (Tm) were found to be affected by both heating rate and composition. It is noticed that the increasing of antimony mass percentage in the glassy matrix is leading to decrease in Tg, Tc, Tp and Tm values. The melting temperature (Tm) of these glasses was found in the range 733–746 K for the first phase and in the range 740–792 K for the second phase. The activation energy of glass transition (Eg), activation energy for crystallization (Ec), Avrami index (n) and fragility index (Fi) were calculated using these specific temperatures. Eg decreases with increasing Sb content in all studied samples, but Eg is increasing in the sample with Sb content of 20%, and hence, it varies between 102.7 and 110.6 kJ approximately, whereas (Ec) decreases with the increase in the Sb content in all the tested samples and varies between 283 and 339 kJ. The fragility index varies between 10 and 26 indicating that the melts of these glasses are strong, and the fragility is minimum. The results were discussed in terms of the average coordination number NC and chemical bond approach.
Raman Spectroscopic Analysis of Highly-Concentrated Antibodies under the Acid-Treated Conditions
Authors: Sato Yusui , Nagatoishi Satoru , Noguchi Shintaro , Tsumoto Kouhei 
Published: May 2023

Abstract
Purpose
Antibody drugs are usually formulated as highly-concentrated solutions, which would easily generate aggregates, resulting in loss of efficacy. Although low pH increases the colloidal dispersion of antibodies, acid denaturation can be an issue. Therefore, knowing the physical properties at low pH under high concentration conditions is important.

Methods
Raman spectroscopy was used to investigate pH-induced conformational changes of antibodies at 50 mg/ml. Experiments in pH 3 to 7 were performed for human serum IgG and recombinant rituximab.

Results
We detected the evident changes at pH 3 in Tyr and Trp bands, which are the sensitive markers of intermolecular interactions. Thermal transition analysis over the pH range demonstrated that the thermal transition temperature (Tm) was highest at pH 3. Acid-treated and neutralized one showed higher Tm than that of pH 7, indicating that their extent of intermolecular interactions correlated with the Tm values. Onset temperature was clearly different between concentrated and diluted samples. Colloidal analyses confirmed the findings of the Raman analysis.

Conclusion
Our studies demonstrated the positive correlation between Raman analysis and colloidal information, validating as a method for evaluating antibody conformation associated with aggregation propensities.