bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outdoor particulate matter exposure affects metabolome in chronic obstructive pulmonary disease: Preliminary study
Authors: Yu Tao , Wu Hanna , Huang Qingxia , Dong Fen , Li Xuexin , Zhang Yushi , Duan Ruirui , Niu Hongtao , Yang Ting 
Published: March 2023

IntroductionThe metabolomic changes caused by airborne fine particulate matter (PM2.5) exposure in patients with chronic obstructive pulmonary disease (COPD) remain unclear. The aim of this study was to determine whether it is possible to predict PM2.5-induced acute exacerbation of COPD (AECOPD) using metabolic markers.MethodsThirty-eight patients with COPD diagnosed by the 2018 Global Initiative for Obstructive Lung Disease were selected and divided into high exposure and low exposure groups. Questionnaire data, clinical data, and peripheral blood data were collected from the patients. Targeted metabolomics using liquid chromatography-tandem mass spectrometry was performed on the plasma samples to investigate the metabolic differences between the two groups and its correlation with the risk of acute exacerbation.ResultsMetabolomic analysis identified 311 metabolites in the plasma of patients with COPD, among which 21 metabolites showed significant changes between the two groups, involving seven pathways, including glycerophospholipid, alanine, aspartate, and glutamate metabolism. Among the 21 metabolites, arginine and glycochenodeoxycholic acid were positively associated with AECOPD during the three months of follow-up, with an area under the curve of 72.50% and 67.14%, respectively.DiscussionPM2.5 exposure can lead to changes in multiple metabolic pathways that contribute to the development of AECOPD, and arginine is a bridge between PM2.5 exposure and AECOPD.
Appearance anxiety and social anxiety: A mediated model of self-compassion
Authors: Gao Jie , Feng Yi , Xu Shicun , Wilson Amanda , Li Hui , Wang Xiaofeng , Sun Xi , Wang Yuanyuan 
Published: March 2023

BackgroundPrevious studies have focused on the comorbidity of appearance anxiety and social anxiety, but few studies have focused on the protective role of self-compassion as underlying this mechanism, in young people like University students. With the increase of prevalence of appearance anxiety and social anxiety in this age group, it is necessary to explore factors that can buffer against the symptoms of these disorders. Therefore, the aims of this study were to research the effect of appearance anxiety and social anxiety, then to examine whether self-compassion has a protective effect on social anxiety.MethodThe study was cross-sectional and conducted online from October 2021 to November 2021 in Jilin Province, China. A total of 63 Universities in the province participated in this study, totaling 96,218 participants, of which 40,065 were males (41.64%) and 56,153 females (58.36%), the mean age of the sample was 19.59 (±1.74). The Appearance Anxiety Scale-Brief Version was used to measure appearance anxiety. The Social Anxiety subscale of the Self-Consciousness Scale was used to measure social anxiety. The Self-Compassion Scale-Short Form was used to measure self-compassion. A structural equation model (SEM) was run to examine the mediating effect of self-compassion on the relationship between appearance anxiety and social anxiety.ResultOverall, appearance anxiety was positively associated with social anxiety [β = 0.334, 95% CI = (0.328, 0.341), p &lt; 0.001], and self-compassion could mediate the effect of appearance anxiety on social anxiety [β = 0.128, 95% CI = (0.124, 0.132), p &lt; 0.001]. Self-compassion played a partial mediating role between appearance anxiety and social anxiety.ConclusionIndividuals with high appearance anxiety are also at higher risk of social anxiety, but self-compassion can buffer against this relationship. These findings begin to explore novel approaches to treat social anxiety and can provide valuable insights for self-compassion training.
Perceived stigma among discharged patients of COVID-19 in Wuhan, China: A latent profile analysis
Authors: Wu Yijin , Dai Zhenwei , Xiao Weijun , Wang Hao , Huang Yiman , Si Mingyu , Fu Jiaqi , Chen Xu , Jia Mengmeng , Leng Zhiwei , Cui Dan , Mak Winnie W. S. , Su Xiaoyou 
Published: March 2023

BackgroundPerceived stigma has greatly influenced the life quality of the COVID-19 patients who recovered and were discharged (RD hereafter). It is essential to understand COVID-19 stigma of RD and its related risk factors. The current study aims to identify the characteristics of perceived COVID-19 stigma in RD using latent profile analysis (LPA), to explore its psycho-social influencing factors, and to determine the cut-off point of the stigma scale using receiver operating characteristic (ROC) analysis.MethodsA cross-sectional study was conducted among COVID-19 RD in 13 communities in Jianghan District, Wuhan City, Hubei Province, China from June 10 to July 25, 2021, enrolling total 1,297 participants. Data were collected on demographic characteristics, COVID-19 perceived stigma, post-traumatic stress disorder (PTSD), anxiety, depression, sleep disorder, fatigue, resilience, social support, and peace of mind. LPA was performed to identify different profiles of perceived COVID-19 stigma level. Univariate analysis and multinominal logistic regression analysis were conducted to explore the influencing factors in different profiles. ROC analyses was carried out to identify the cut-off value of perceived stigma.ResultsAmong the participants, three profiles of perceived stigma were identified: “low perceived COVID-19 stigma” (12.8%), “moderate perceived COVID-19 stigma” (51.1%), and “severe perceived COVID-19 stigma” (36.1%). Multinominal logistic regression analysis revealed that older age, living with other people, anxiety, and sleep disorder were positively associated with moderate perceived COVID-19 stigma, while higher educational level was negatively associated with moderate perceived COVID-19 stigma. Female, older age, living with other people, anxiety, and sleep disorder were positively associated with severe perceived COVID-19 stigma, while higher educational level, social support, and peace of mind were negatively associated with severe perceived COVID-19 stigma. ROC curve of the Short Version of COVID-19 Stigma Scale (CSS-S) for screening perceived COVID-19 stigma showed that the optimal cut-off value was ≥ 20.ConclusionThe study focuses on the issue of perceived COVID-19 stigma and its psycho-socio influencing factors. It provides evidence for implementing relevant psychological interventions to COVID-19 RD.
The impact of monthly air pollution exposure and its interaction with individual factors: Insight from a large cohort study of comprehensive hospitalizations in Guangzhou area
Authors: Ju Xu , Yimaer Wumitijiang , Du Zhicheng , Wang Xinran , Cai Huanle , Chen Shirui , Zhang Yuqin , Wu Gonghua , Wu Wenjing , Lin Xiao , Wang Ying , Jiang Jie , Hu Weihua , Zhang Wangjian , Hao Yuantao 
Published: March 2023

BackgroundAlthough the association between short-term air pollution exposure and certain hospitalizations has been well documented, evidence on the effect of longer-term (e. g., monthly) air pollution on a comprehensive set of outcomes is still limited.MethodA total of 68,416 people in South China were enrolled and followed up during 2019–2020. Monthly air pollution level was estimated using a validated ordinary Kriging method and assigned to individuals. Time-dependent Cox models were developed to estimate the relationship between monthly PM10 and O3 exposures and the all-cause and cause-specific hospitalizations after adjusting for confounders. The interaction between air pollution and individual factors was also investigated.ResultsOverall, each 10 μg/m3 increase in PM10 concentration was associated with a 3.1% (95%CI: 1.3%−4.9%) increment in the risk of all-cause hospitalization. The estimate was even greater following O3 exposure (6.8%, 5.5%−8.2%). Furthermore, each 10 μg/m3 increase in PM10 was associated with a 2.3%-9.1% elevation in all the cause-specific hospitalizations except for those related to respiratory and digestive diseases. The same increment in O3 was relevant to a 4.7%−22.8% elevation in the risk except for respiratory diseases. Additionally, the older individuals tended to be more vulnerable to PM10 exposure (Pinteraction: 0.002), while the alcohol abused and those with an abnormal BMI were more vulnerable to the impact of O3 (Pinteraction: 0.052 and 0.011). However, the heavy smokers were less vulnerable to O3 exposure (Pinteraction: 0.032).ConclusionWe provide comprehensive evidence on the hospitalization hazard of monthly PM10 and O3 exposure and their interaction with individual factors.
Morphological features of basivertebral foramen among different age groups: Recognition in spine
Authors: Wang Qiang , Jin Benyu , Zhang Jianfeng 
Published: March 2023

BackgroundBasivertebral foramen (BF) is a vessel and nerve passage in the posterior wall of vertebral body (VB). Our goal was to report BF's morphological characteristics in different age groups of mainland Chinese adults and to evaluate the relationship between BF's morphology and factors such as age, gender, heavy work, size and level of VB.MethodsWe enrolled 300 adults among persons who came to our hospital for health examination. We measured BFs and VBs’ parameters on T1 weighted sagittal lumbar spine MR images. We also assessed following potential predictors: gender, body height, body weight, body mass index, alcohol use, habits of smoking and drinking, type of work (physical work or non-physical work). A stepwise multivariate linear regression analysis was conducted to identify predictors of BF's height.ResultsPeople above 60 have significantly bigger BFHr than those in young adulthood and in the middle ages at all five levels, while they have shallowest BFs, especially at L3. Multiple linear regression resulted in a formula that accounted for 30.1% of the variability in the height of basivertebral foramen. Significant predictors included: gender, age, level, vertebral height and heavy work.ConclusionAge is the highest weight in all factors on the height of BF. BF is closer to the upper endplate. The BF was relatively higher and deeper in the female lumbar spine. Heavywork results in lower BF. Last but not the least, as we supposed, BF gets shallower and higher compare to VB with age.Level of evidencePrognostic level III. See instructions for authors for a complete description of levels of evidence.
Saneamento e saúde: casos arboviroses associado a falta de tratamento de esgoto na cidade de Serra Grande-PB
Authors: Da Silva Crisóstomo Hermes Soares Trajano , Bezerra Arthur Levi da Costa , Bezerra Thaylles Yara da Costa , Alexandre Mateus Dantas , Abrantes Rafael Marques , Dos Santos Gleydson Giordan Oliveira , Pires José Jefferson Barro , Leite Simone Francisca Lopes da Silva 
Published: March 2023

Atualmente cerca de 5,3 bilhões pessoas vivem em área de restrição hídrica por, pelo menos, um mês ao ano e por volta de 500 milhões de pessoas estão em áreas onde o consumo de água excedente está diretamente ligado à qualidade da água já que contaminação das fontes pode impedir diferentes tipos de uso. 24 da mesma Resolução, dispõem sobre as condições e padrões de lançamento de efluentes em corpos hídricos, o qual estabelece que qualquer fonte poluidora só poderá ser lançada em corpos de água, seja de forma direta ou indireta, após tratamento devido, o qual dever seguir padrões e condições dispostas nessa Resolução. Umas das proposta para a melhoria no fornecimento de serviço de saneamento básico surge a partir do Estudo de Regionalização da prestação de serviços de saneamento o básico de água e esgotamento sanitário na Paraíba são projetados para atender a lei federal 14.026/2020, permitindo que os países promulguem por meio de leis complementares microrregiões de Saneamento Básico para fornecer Saúde, cuja finalidade é organizar, planejar, executar e operado em conjunto e integrado pelo Estado e os municípios que os compõem . Principal objetivo da Lei mencionada é garantir o acesso a propagação dos serviços de água e esgoto no território nacional, considerando os índices elevados na ausência desses serviços que causa negatividade em setores importante como saúde pública, meio ambiente, educação, econômico e social, sendo assim, um instrumento que efetiva fronteiras e limites com intuito de expandir a eficiência e o impacto das políticas públicas. Dessa forma este trabalho teve como objetivo levantar questões acerca da política Municipal sobre os serviços de saneamento básico na cidade de Serra Grande-PB e os casos de dengue que a população foi acometida. É importante ressaltar que a cidade em questão é um considerado município e pequeno porte com uma população de quase 3 mil habitantes. Para metodologia Em geral, a abordagem adotada para atingir os objetivos da pesquisa caracteriza-se pelo uso de métodos descritivos, pesquisa de campo e revisão bibliográfica em artigos científicos, livros, dissertações, anais de congressos, publicações do Ministério da Saúde e do MCidades, dados do SNIS, sites da Internet e legislações pertinentes. Como resultados pode ser constatado neste estudo, que a cidade de Serra Grande carece de estruturas de saneamento básico e de serviços de coleta, transporte e tratamento de esgoto visando prevenir a propagação de doenças, proteger o meio ambiente e garantir a qualidade de vida.
Pelaksanaan Pasal 35 Ayat 1 Huruf C Peraturan Kapolri Nomor 9 Tahun 2012 Tentang Surat Izin Mengemudi Syarat Pembuatan SIM D Bagi Disabilitas
Authors: Elprido Surant , Fitriantica Agnes 
Published: March 2023

Indonesia sebagai negara hukum wajib menjunjung tingga HAM setiap warga negaranya. HAM mutlak menjadi kedaulatan tiap-tiap individu, termasuk penyandang disabilitas. Konstitusi menjamin hak bagi penyandang disabilitas, diantaranya hak keadilan dan perlindungan hukum, hak aksesibilitas, serta hak pelayanan publik. Penelitian ini bertujuan untuk meneliti tentang peyalanan proses penerbitan SIM bagi penyandang disabilitas yang menjadi hak setiap warga negara yang memenuhi syarat. Dalam hal ini, substansi yang dibahas adalah Pasal 35 Ayat 1 Huruf C Peraturan Kapolri Nomor 9 Tahun 2012 Tentang SIM Berkaitan Dengan Syarat Karakteristik Pembuatan SIM D Bagi Disabilitas. Dalam hal ini studi kasus diambil di Kantor Satlantas Polres Metro Jakarta Barat. Metode yang digunakan dalam penelitian ini adalah metode hukum normatif dengan pendekatan yuridis empiris. Pengumpulan Data dilakukan menggunakan teknik wawancara dengan informan dan dianalisis secara kualitatif. Berdasarkan hasil penelitian didapatkan kesimpulan bahwa implementasi penerbitan SIM bagi penyandang disabilitas berdasarkan Peraturan Kapolri di Wilayah Hukum Polres Metro Jakarta Barat sudah cukup baik, meskipun secara komprehensif belum efektif secara maksimal karena pelaksanaan teknis di lapangan yang belum dapat disesuaikan dengan keadaan penyandang disabilitas. Adapun terkait kriteria fisik bagi penyandang disabilitas yang hendak mengurus kepemilikan SIM adalah tidak tulis, tidak buta total dan buta warna, sanggup mengendarai kendaraan bermotor.
Eksistensi Akal Dalam Pembentukan Ijtihad Sebagai Dalil Hukum/ The Existence of Rational in the Formation of Ijtihad as a Legal Postulates
Authors: Harisman  
Published: March 2023

Abstrak: Artikel ini dimaksudkan untuk mengkaji eksistensi akal dalam pembentukan ijtihad sebagai dalil hukum. Pengunaan akal sudah menjadi alternatif pilihan bagi para ulama didalam menemukan jawaban atas persoalan-persolan kontemporer yang berkembang saat ini Meskipun sampai saat ini penggunaan akal dalam berijtihad masih ada perbedaan pendapat. Guna memahami penggunaan akal dalam berijtihad untuk melahirkan dalil hukum dilakukanlah penelitian normatife dengan menggunakan bahan hukum sekunder yang bersumber dari kepustakaan. Bahan yang dikumpulkan dianalisis secara kualitatif dan kemudian dideskriptifkan. Berdasarkan analisis yang dilakukan diperoleh bahwa akal sebagai alat dan atau sumber untuk berfikir dalam ijtihad guna menemukan dalil dalil hukum baik yang didasarkan pada Al Qur’an dan hadist maupun yang tidak ada di jelaskan. Dalam kajian usul fikih, kata akal diidentikkan pula dengan kata ra’yu.
Peran Iklan Online Terhadap Keputusan Konsumen Untuk Membeli Jambu Mente. Studi Pada UKM di Kecamatan Lakudo Kabupaten Buton Tengah
Authors: Yusuf Yusuf 
Published: March 2023

Perkembangan teknologi saat ini memegang peran penting dalam perubahan perilaku manusia dalam aktivitas ekonominya, terutama upaya-upaya dalam memenuhi kebutuhan konsumsinya. Pemanfaatan teknologi informasi sebagai media pemasaran menjadi penting dalam menyampaikan produk kepada konsumen, Media social merupakan lingkungan interaksi manusia yang saat ini digunakan oleh semua kalangan sehingga iklan secara online sangat tepat digunakan untuk pemasaran. Iklan online yang dikaji adalah cara menyisikapi iklan, kemampuan mengingat. dan keseringan mengunjungi (klik) iklan. Ketiga hal tersebut merupakan factor penting dalam periklanan online yang mampu mempengaruhi keputusan konsumen untuk membeli jambu mente pada UKM di kecamatan Lakudo Kabupaten Buton Tengah. Penelitian dilakukan dengan metode survey pada 80 responden UKM produk jambu mente yang tersebar pada wilayah kecataman Lakudo Kabupaten Buton Tengah yang ditelusuri melalui market place di media social facebook dan Instagram. Data dianalisis dengan regresi linier berganda. Hasil analisis diperoleh bahwa sikap terhadap iklan online, kemampuan mengingat iklan online dan frekuensi klik iklan online berpengaruh positif dan signifikan terhadap keputusan pembelian.
Strategi Penjualan Produk Kopi Bubuk Jenis Robusta di Desa Rongi sebagai Upaya Mendukung Wisata Bahari Kecamatan Sampolawa Kabupaten Buton Selatan
Authors: Purnamasari Wa Ode Dian , Azizu Azelia Monica 
Published: March 2023

Penelitian ini bertujuan untuk menganalisis faktor yang menjadi pendorong dan penghambat penjualan kopi bubuk Rongi sebagai upaya mendukung wisata Bahari di Kabupaten Buton Selatan dan merumuskan strategi yaang tepat dalam peningkatan penjualan produk kopi bubuk Rongi jenis robusta dalam upaya mendukung wisata Bahari di Kabupaten Buton Selatan. Penelitian dilaksanakan di Desa Ronggi Kecamatan Sampolawa Kabupaten Buton Selatan pada bulan September sampai dengan Oktober 2021. Populasi pada penelitian ini adalah seluruh Usaha Mikro Kecil dan Menengah (UMKM) penjual kopi yang ada di Ronggi Kecamatan Sampolawa Kabupaten Buton Selatan yang berjumlah 100. Sampel penelitian ini adalah 24 UMKM penjual kopi sebagai responden. Hasil penelitian menunjukkan bahwa kombinasi yang dilakukan pada strategi eksternal dan internal adalah pengembangan dan penjualan yang cocok untuk dijadikan usaha Kopi Robusta Bubuk untuk mendukung wisata Bahari Kecamatan Sampolawa adalah strategi agresif, dengan metode menggunakan kekuatan (strength) untuk memanfaatkan peluang (opportunity). Strategi SO : Kegiatan produksi kopi bubuk rongi yang berstandar sehingga menciptakan kualitas kopi yang baik. Strategi WO : Mengupdate inovasi produk yang menyesuaikan dengan tuntutan konsumen dengan bermacam varian rasa, teknologi sebagai sarana promosi seperti facebook dan Instagram, serta merektur karyawan yang professional dibidang agribisnis. Strategi ST : Memanfaatkan mitra untuk mendapatkan bahan utama produk yang lebih muda dan terjangkau sehingga bisa menekan biaya produksi dan menciptakan harga yang terjangkau untuk konsumen. Strategi WT : Meningkatkan sarana dan prasarana dengan pemanfataan teknologi sehingga dapat bersaing dengan produk secara nasional, selalu memperbanyak mitra penyaluran produk sehingga permintaan produk meningkat.
Nilai Tambah Pengolahan Sambal Boran Kemasan Pada UKM Silvana Food
Authors: Rianti Titis Surya Maha , Syanthori Ahmad Dedy , Sari Dina Kartika 
Published: March 2023

Sambal Boran adalah sambal khas Lamongan yang diolah dengan bahan dasar cabai. Penelitian ini bertujuan untuk menganalisis nilai tambah dari Sambal Boran kemasan di UKM Silvana Food. Jenis data yang peneliti gunakan pada penelitian ini ialah data primer yang diperoleh dari wawancara terhadap key informan yaitu pemilik UKM Silvana Food. Data yang dididapatkan kemudian dianalisis dengan menghitung biaya, pendapatan, dan nilai tambah dengan metode Hayami. Dari hasil perhitungan diperoleh total biaya bahan baku rata-rata yang dikeluarkan adalah Rp 25.000/kg, sumbangan input lain Rp 360.600/kg. Nilai output Rp 25.000/unit dan nilai tambah sebesar Rp 389.400/kg. Pendapatan yang didapatkan tenaga kerja Rp 37.500/unit. Dengan nilai margin sebesar Rp 750.000/kg, besarnya margin dari pengemasan sambal boran ini menunjukkan bahwa penjualan produk sambal boran kemasan dapat disimpulkan bahwa UKM Silvana Food mendapatkan nilai tambah dari pengolahan komoditas cabai menjadi sambal boran kemasan dan usaha tersebut layak untuk dikembangkan. Diharapkan pemilik UKM Silvana Food dapat meningkatkan pemasaran online melalui sosial commerce dan menjalin mitra dengan toko oleh-oleh setempat sehingga semakin berkembang dan permintaannya semakin meningkat di era pandemi covid-19.
IMPLEMENTASI PERATURAN WALI KOTA KEDIRI NOMOR 16 TAHUN 2020 TENTANG PENGENDALIAN KEGIATAN HIBURAN DAN PERDAGANGAN DALAM RANGKA PERCEPATAN PENANGANAN CORONA VIRUS DISEASE 2019
Authors: Sultan Sahara  , Suwarno  , Teguh Pramono  
Published: March 2023

Kebijakan yang ditetapkan Pemerintah Kota Kediri sejak awal pandemi Covid-19 tidak melakukan lock down dikarenakan menginginkan perekonomian masyarakat harus tetap berjalan. Wali Kota Kediri pada tanggal 18 Mei 2020 menetapkan Peraturan Wali Kota Kediri Nomor 16 Tahun 2020 Tentang Pengendalian Kegiatan Hiburan dan Perdagangan dalam Rangka Percepatan Penanganan Corona Virus Disease 2019. Pemerintah Kota Kediri telah menetapkan wajib melaksanakan protokol kesehatan, pembatasan jam operasional dan pengunjung kegiatan usaha. Metode penelitian yang digunakan yakni kualitatif, penyajian data berjenis deskriptif dengan pendekatan studi kasus. Fokus penelitian menganalisis implementasi implementasi peraturan dengan konsep George C. Edward III yang memiliki 4 (empat) variabel yakni; komunikasi, sumber daya, disposisi dan struktur birokrasi. Sumber data yakni data primer dan sekunder. Teknik sampling yakni purposive sampling. Teknik pengumpulan data; wawancara terstruktur maupun tidak tersturktur, dokumentasi, observasi. Keabsahan data; triangulasi.
Hasil analisis sebagai berikut: 1) Variabel Komunikasi kebijakan dari dimensi transmisi dan kejelasan sudah baik, kendala terdapat pada dimensi konsistensi. 2) Variabel sumber daya dari dimensi SDM, informasi, kewenangan dan Fasilitas sudah baik. 3) Variabel disposisi mengalami masalah pada dimensi efek disposisi, melaksanakan pengaturan birokrasi; baik, dimensi insentif; menemui kendala. 4) Variabel struktur birokrasi baik. SOP; baik, fragmentasi; baik. Implementasi kebijakan publik menemui kendala yakni masih banyaknya masyarakat yang abai terhadap protokol kesehatan, masih belum tertibnya pedagang, terdapat masyarakat yang berparadigma keliru mengenai virus Covid-19, adanya pengurangan upah karyawan menyebabkan terjadinya pelanggaran jam operasional usaha.
THE INFLUENCE OF STORE ATMOSPHERE ON CONSUMERS' INTEREST IN BUYING AT TANJUNG'S U & ME CAFÉ
Authors: Nadi Fikri Rijali  
Published: March 2023

The purpose of this study is to determine the impact of store atmosphere on consumer purchasing interest at the U & Me Tanjung Cafe.Customers of U & Me Cafe make up the population of this study.
The sample size in this study was 67 people, with a sampling technique of non-probability sampling and a sample size determined by convenience sampling. Data was gathered through a survey or questionnaire distributed to respondents. The Generalized Structured Component Analysis (GesCA) analysis tool is used in this study.
The study's findings indicate that store atmosphere has a significant impact on purchase intent. The findings of this study suggest that a store environment that meets consumer expectations will entice customers to make purchases. Furthermore, a positive store atmosphere is one of the factors that determines the company's long-term viability.
Keywords: Store atmosphere, Purchase Intention, U & Me Cafe