bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Komunikasi Radio Kharisma 95,6 FM Bengkulu Utara Dalam Meningkatkan eksistensi Sebagai Lembaga Penyiaran Publik Lokal Melalui Program Siaran “Sapa Pagi”
Authors: Aji Muhammad Rama , Supriyadi Dedy , Budiman Dwi Aji 
Published: February 2023

Penelitian ini menggunakan teknik analisis kualitatif deskriptif dan pengumpulan data yaitu dengan observasi, wawancara, dan dokumentasi, serta mencari referensi melalui buku, jurnal, skripsi dan artikel yang berhubungan dengan penelitian. Penelitian ini juga menggunakan teknik analisis data melalui pengumpulan data, reduksi data, display data, dan verifikasi dan penarikan kesimpulan. Teori yang digunakan dalam penelitian ini adalah teori Ekologi Media, dengan mengikuti pernyataan dari Dimmick dan Rohtenbuhler, yaitu ada tiga sumber utama dari penunjang hidup suatu media, yaitu types of content, types of audience, dan capital. Hasil dari penelitian ini adalah bahwa LPPL Radio Kharisma 95.6 FM Bengkulu Utara telah melakukan upaya dan memiliki strategi tersendiri yang telah mencakup 3 sumber media dalam bertahan hidup, yaitu memanfaatkan ruang komuikasi sebagai pengumpulan ide pendapat dengan semua pihak radio, kemudian menerapkan tekhnik komunikasi yaitu memperhatikan tempo dan intonasi, dan memanfaatkan dengan maksimal sumber dana operasional utama yaitu APBD lalu mengikut sertakan semua crew radio untuk mengikuti pelatihan untuk meningkatkan kualitas SDM.
Kata Kunci: Strategi Komunikasi, Radio, LPPL, Ekologi Media
FooDia-Net. A technology platform for nutrition education and active people involvement in the prevention of diabetes mellitus: results from the first field trial
Authors: Savarese Mariarosaria , Bosio Caterina , Graps Elisabetta Anna , Graffigna Guendalina 
Published: February 2023

Introduction: Type 2 diabetes mellitus (DM) is one of the most widespread chronic diseases in the world and, by its nature, it affects several disciplines. Patients often appear unaware and lacking an adequate lifestyle and appropriate nutritional education to prevent its aggravation. Consequently, it appears essential to promote educational initiatives aimed at helping patients diagnosed with type 2 DM to contain the disease progress. FooDia-Net is a project financed by the Ministry of Health which took place between 2017 and 2020 in 5 Italian regions, aimed at experimenting an innovative operating model of multiprofessional and cross-disciplinary management in the prevention of type 2 DM.
Method: The FooDia-Net protocol was tested through a pilot project which enabled the evaluation food literacy levels and patient engagement through the administration of pre- and post-performance self-assessment questionnaires to evaluate the educational exercises proposed to the panel.
Results: Out of 166 eligible patients, 38 completed the protocol (23%); results show a significant improvement in the levels of food literacy and, from the engagement point of view, despite not being significant statistically, good improvements were registered.
Discussion and conclusion: Results were encouraging with regards to the multidisciplinary management of patients with type 2 diabetes. The FooDia-Net platform ensured continuity of care and emotional support for patients remotely.
Developing Realistic Mathematics Education Material to Build Students Mathematical Understanding Concepts Grade VII Junior High School on Linear Equation in Two Variables
Authors: Budiyanto Aris , Nurwiatin Neng , Ismah Ismah 
Published: February 2023

Dilatarbelakangi oleh pentingnya pemahaman konsep matematika siswa terutama pada materi Sistem Persamaan Linier Dua Variabel. penelitian ini bertujuan untuk mengembangkan bahan ajar matematika berbasis Realistic Mathematic Education untuk membangun pemahaman konsep siswa. Bahan ajar dikembangkan berdasarkan model 4-D yang direkomendasikan oleh Thiangrajan dan dimodifikasi menjadi defined, designed, dan developed. Dengan demikian, pembelajaran matematika realistik akan mempunyai kontribusi terhadap kemampuan berpikir matematika siswa. Populasi penelitian ini adalah seluruh siswa kelas VIIC Sekolah Bina Insan Mandiri dan subjek penelitian ini terdiri dari sepuluh siswa yang dipilih secara purposive sampling berdasarkan hasil evaluasi dan keaktifan siswa selama pembelajaran. Bahan ajar yang dikembangkan dilakukkan validitas dengan teknik analisas diskriptif, sementara data kantitatif yang diperoleh dihitung berdasarkan rata-rata sekor. Berdasarkan uji validitas oleh ahli instrumen yang dikembangkan dinyatakan valid dan berkriteria efektif berdasarkan hasil uji coba kepada siswa, serta layak untuk digunakan dalam pembelajaran.
The effect of a mesenteric traction syndrome on internal carotid artery blood flow
Authors: Olesen Niels D. , Egesborg Astrid H. , Frederiksen Hans-Jørgen , Svendsen Lars B. , Secher Niels H. 
Published: February 2023

PurposeDuring abdominal surgery, manipulation of internal organs may induce a “mesenteric traction syndrome” (MTS) including a triad of flushing, hypotension, and tachycardia that lasts for approximately 30 min. We evaluated whether MTS affects internal carotid artery blood flow.MethodsThis prospective cohort study included 27 patients aged 65 ± 11 years (mean ± SD) undergoing stomach resection (n = 12), esophageal resection (n = 14), or gastro-entero anastomosis (n = 1) during propofol-remifentanil and thoracic epidural anesthesia. Duplex ultrasound determined internal carotid artery blood flow, laser Doppler flowmetry assessed forehead skin blood flow, and near-infrared spectroscopy determined cerebral oxygenation. Development of MTS was defined by flushing within 60 min after incision.ResultsSeven patients developed MTS 22 [20–26; median (IQR)] min after incision and at that time the change in heart rate (to 87 ± 13 vs. 70 ± 11 bpm; P = 0.0007) and skin blood flow (to 214 (134–269) vs. 84 (59-112 PU; P = 0.0044) was higher in the patients who developed MTS as compared to those who did not, while mean arterial pressure (63 ± 13 vs. 64 ± 14 mmHg; P = 0.1433), cerebral oxygenation (69 ± 9% vs. 63 ± 10%; P = 0.2485), and internal carotid artery flow (225 ± 53 vs. 203 ± 69 ml/min; P = 0.9529) were similar.ConclusionHemodynamic perturbations are observed in some patients in response to manipulation of the viscera, but the development of MTS appears not to influence internal carotid artery flow.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT02951273?term=NCT02951273&amp;rank=1, identifier: NCT02951273.
Effects of age, body height, body weight, body mass index and handgrip strength on the trajectory of the plantar pressure stance-phase curve of the gait cycle
Authors: Wolff Christian , Steinheimer Patrick , Warmerdam Elke , Dahmen Tim , Slusallek Philipp , Schlinkmann Christian , Chen Fei , Orth Marcel , Pohlemann Tim , Ganse Bergita 
Published: February 2023

The analysis of gait patterns and plantar pressure distributions via insoles is increasingly used to monitor patients and treatment progress, such as recovery after surgeries. Despite the popularity of pedography, also known as baropodography, characteristic effects of anthropometric and other individual parameters on the trajectory of the stance phase curve of the gait cycle have not been previously reported. We hypothesized characteristic changes of age, body height, body weight, body mass index and handgrip strength on the plantar pressure curve trajectory during gait in healthy participants. Thirty-seven healthy women and men with an average age of 43.65 ± 17.59 years were fitted with Moticon OpenGO insoles equipped with 16 pressure sensors each. Data were recorded at a frequency of 100 Hz during walking at 4 km/h on a level treadmill for 1 minute. Data were processed via a custom-made step detection algorithm. The loading and unloading slopes as well as force extrema-based parameters were computed and characteristic correlations with the targeted parameters were identified via multiple linear regression analysis. Age showed a negative correlation with the mean loading slope. Body height correlated with Fmeanload and the loading slope. Body weight and the body mass index correlated with all analyzed parameters, except the loading slope. In addition, handgrip strength correlated with changes in the second half of the stance phase and did not affect the first half, which is likely due to stronger kick-off. However, only up to 46% of the variability can be explained by age, body weight, height, body mass index and hand grip strength. Thus, further factors must affect the trajectory of the gait cycle curve that were not considered in the present analysis. In conclusion, all analyzed measures affect the trajectory of the stance phase curve. When analyzing insole data, it might be useful to correct for the factors that were identified by using the regression coefficients presented in this paper.
Phosphorylation of the actin-binding protein profilin2a at S137 modulates bidirectional structural plasticity at dendritic spines
Authors: Cornelius Jonas , Haak Stefan , Rothkegel Martin , Korte Martin , Michaelsen-Preusse Kristin 
Published: February 2023

Background: Synaptic plasticity requires constant adaptation of functional and structural features at individual synaptic connections. Rapid re-modulation of the synaptic actin cytoskeleton provides the scaffold orchestrating both morphological and functional modifications. A major regulator of actin polymerization not only in neurons but also in various other cell types is the actin-binding protein profilin. While profilin is known to mediate the ADP to ATP exchange at actin monomers through its direct interaction with G-actin, it additionally is able to influence actin dynamics by binding to membrane-bound phospholipids as phosphatidylinositol (4,5)-bisphosphate (PIP2) as well as several other proteins containing poly-L-proline motifs including actin modulators like Ena/VASP, WAVE/WASP or formins. Notably, these interactions are proposed to be mediated by a fine-tuned regulation of post-translational phosphorylation of profilin. However, while phosphorylation sites of the ubiquitously expressed isoform profilin1 have been described and analyzed previously, there is still only little known about the phosphorylation of the profilin2a isoform predominantly expressed in neurons.Methods: Here, utilizing a knock-down/knock-in approach, we replaced endogenously expressed profilin2a by (de)phospho-mutants of S137 known to alter actin-, PIP2 and PLP-binding properties of profilin2a and analyzed their effect on general actin dynamics as well as activity-dependent structural plasticity.Results and Discussion: Our findings suggest that a precisely timed regulation of profilin2a phosphorylation at S137 is needed to mediate actin dynamics and structural plasticity bidirectionally during long-term potentiation and long-term depression, respectively.
Predictive value of remnant cholesterol level for all-cause mortality in heart failure patients
Authors: Zhao Lang , Zhao Xuemei , Tian Pengchao , Liang Lin , Huang Boping , Huang Liyan , Feng Jiayu , Zhang Yuhui , Zhang Jian 
Published: February 2023

BackgroundLower cholesterol levels are associated with increased mortality in heart failure (HF) patients. Remnant cholesterol corresponds to all cholesterol not found in high-density lipoprotein (HDL) and low-density lipoprotein (LDL). The prognostic role of remnant cholesterol in HF remains unknown.ObjectiveTo reveal the relationship between the baseline remnant cholesterol level and all-cause mortality in HF patients.MethodsThis study enrolled 2,823 patients hospitalized for HF. Kaplan–Meier analysis, Cox regression, C-statistic, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to evaluate the prognostic value of remnant cholesterol for all-cause mortality in HF.ResultsThe mortality rate was lowest in the fourth quartile of remnant cholesterol, which had an adjusted hazard ratio (HR) for death of 0.56 [HR: 0.39, 95% confidence interval (CI): 0.46–0.68, p &lt; 0.001] relative to the first quartile. After adjustment, a one-unit increase in the level of remnant cholesterol was associated with a 41% decrease in the risk of all-cause mortality (HR: 0.59, 95% CI: 0.47–0.73, p &lt; 0.001). A refinement in risk prediction was observed after adding remnant cholesterol quartile to the original model (ΔC-statistic = 0.010, 95% CI: 0.003–0.017; NRI = 0.036, 95% CI: 0.003–0.070; IDI = 0.025, 95% CI: 0.018–0.033; all p &lt; 0.05).ConclusionLow remnant cholesterol levels are associated with increased all-cause mortality in HF patients. The addition of the remnant cholesterol quartile improved the predictive value over traditional risk factors.Clinical Trial RegistrationClinicalTrials.gov, Unique Identifier: NCT02664818.
General practitioners’ perceptions on opportunistic single-time point screening for atrial fibrillation: A European quantitative survey
Authors: Vermunicht Paulien , Grecu Mihaela , Deharo Jean-Claude , Buckley Claire M. , Palà Elena , Mairesse Georges H. , Farkowski Michal M. , Bergonti Marco , Pürerfellner Helmut , Hanson Coral L. , Neubeck Lis , Freedman Ben , Witt Henning , Hills Mellanie T. , Lund Jenny , Giskes Katrina , Engler Daniel , Schnabel Renate B. , Heidbuchel Hein , Desteghe Lien ,   for the AFFECT-EU investigators
Published: February 2023

BackgroundThere is no clear guidance on how to implement opportunistic atrial fibrillation (AF) screening in daily clinical practice.ObjectivesThis study evaluated the perception of general practitioners (GPs) about value and practicalities of implementing screening for AF, focusing on opportunistic single-time point screening with a single-lead electrocardiogram (ECG) device.MethodsA descriptive cross-sectional study was conducted with a survey developed to assess overall perception concerning AF screening, feasibility of opportunistic single-lead ECG screening and implementation requirements and barriers.ResultsA total of 659 responses were collected (36.1% Eastern, 33.4% Western, 12.1% Southern, 10.0% Northern Europe, 8.3% United Kingdom &amp; Ireland). The perceived need for standardized AF screening was rated as 82.7 on a scale from 0 to 100. The vast majority (88.0%) indicated no AF screening program is established in their region. Three out of four GPs (72.1%, lowest in Eastern and Southern Europe) were equipped with a 12-lead ECG, while a single-lead ECG was less common (10.8%, highest in United Kingdom &amp; Ireland). Three in five GPs (59.3%) feel confident ruling out AF on a single-lead ECG strip. Assistance through more education (28.7%) and a tele-healthcare service offering advice on ambiguous tracings (25.2%) would be helpful. Preferred strategies to overcome barriers like insufficient (qualified) staff, included integrating AF screening with other healthcare programs (24.9%) and algorithms to identify patients most suitable for AF screening (24.3%).ConclusionGPs perceive a strong need for a standardized AF screening approach. Additional resources may be required to have it widely adopted into clinical practice.
The pre-ejection period is a highly stress dependent parameter of paramount importance for pulse-wave-velocity based applications
Authors: Pilz Niklas , Patzak Andreas , Bothe Tomas L. 
Published: February 2023

PurposeThe pulse-wave-velocity, is used for indirect, cuff-less, continuous blood pressure estimation. It is commonly detected by measuring the time delay between a defined point in an ECG and the arrival of the peripheral pulse wave (e.g., oxygen saturation sensor). The period between electrical stimulation of the heart (ECG) and actual blood ejection from the heart is called the pre-ejection period (PEP). This study aims at characterizing the PEP under mental and physical stress with focus on its relations to other cardiovascular parameters such as heart rate and importance for blood pressure (BP) estimation.MethodsWe measured the PEP in 71 young adults at rest, under mental (TSST) and physical stress (ergometer) via impedance-cardiography.ResultsThe PEP is highly dependent on mental and physical load. It is strongly correlated with indicators of sympathetic strain (p &lt; 0.001). At rest (mean 104.5 ms), the PEP shows a high interindividual variability but small intraindividual variability. Mental stress decreases the PEP by 16% (mean 90.0 ms) while physical stress halves PEP (mean 53.9 ms). The PEP does correlate differently with heart rate under differing circumstances (rest: R2 0.06, mental stress: R2 0.29, physical stress: R2 0.65). Subsequently, using PEP and heart rate enables the discrimination of rest, mental and physical strain with a positive predictive value of 93%.ConclusionThe PEP is a cardiovascular parameter with large interindividual variability at rest and subject-depended dynamic under load which is of great importance for ECG-based pulse-wave-velocity (PWV) determination. Considering its variability and large impact on the pulse arrival time, PEP is a crucial factor in PWV based BP estimation.
Diagnostic efficiency of existing guidelines and the AI-SONIC™ artificial intelligence for ultrasound-based risk assessment of thyroid nodules
Authors: Yang Linxin , Lin Ning , Wang Mingyan , Chen Gaofang 
Published: February 2023

IntroductionThe thyroid ultrasound guidelines include the American College of Radiology Thyroid Imaging Reporting and Data System, Chinese-Thyroid Imaging Reporting and Data System, Korean Society of Thyroid Radiology, European-Thyroid Imaging Reporting and Data System, American Thyroid Association, and American Association of Clinical Endocrinologists/American College of Endocrinology/Associazione Medici Endocrinologi guidelines. This study aimed to compare the efficiency of the six ultrasound guidelines vs. an artificial intelligence system (AI-SONICTM) in differentiating thyroid nodules, especially medullary thyroid carcinoma.MethodsThis retrospective study included patients with medullary thyroid carcinoma, papillary thyroid carcinoma, or benign nodules who underwent nodule resection between May 2010 and April 2020 at one hospital. The diagnostic efficacy of the seven diagnostic tools was evaluated using the receiver operator characteristic curves.ResultsFinally, 432 patients with 450 nodules were included for analysis. The American Association of Clinical Endocrinologists/American College of Endocrinology/Associazione Medici Endocrinologi guidelines had the best sensitivity (88.1%) and negative predictive value (78.6%) for differentiating papillary thyroid carcinoma or medullary thyroid carcinoma vs. benign nodules, while the Korean Society of Thyroid Radiology guidelines had the best specificity (85.6%) and positive predictive value (89.6%), and the American Thyroid Association guidelines had the best accuracy (83.7%). When assessing medullary thyroid carcinoma, the American Thyroid Association guidelines had the highest area under the curve (0.78), the American College of Radiology Thyroid Imaging Reporting and Data System guidelines had the best sensitivity (90.2%), and negative predictive value (91.8%), and AI-SONICTM had the best specificity (85.6%) and positive predictive value (67.5%). The Chinese-Thyroid Imaging Reporting and Data System guidelines had the best under the curve (0.86) in diagnosing malignant tumors vs. benign tumors, followed by the American Thyroid Association and Korean Society of Thyroid Radiology guidelines. The best positive likelihood ratios were achieved by the Korean Society of Thyroid Radiology guidelines and AI-SONICTM (both 5.37). The best negative likelihood ratio was achieved by the American Association of Clinical Endocrinologists/American College of Endocrinology/Associazione Medici Endocrinologi guidelines (0.17). The highest diagnostic odds ratio was achieved by the American Thyroid Association guidelines (24.78).DiscussionAll six guidelines and the AI-SONICTM system had satisfactory value in differentiating benign vs. malignant thyroid nodules.
Heat transfer of supercritical pressure water in helical tubes
Authors: Liu Mengmeng , Zhang Zhen , Yang Xingtuan , Jiang Shengyao 
Published: February 2023

Subcritical steam generators in the current high-temperature gas-cooled reactor pebble-bed module in China can be replaced by supercritical steam generators to better coordinate the reactors and supercritical steam turbine unit to improve the thermal efficiency with no fluid phase change at supercritical pressures. The heat transfer of supercritical-pressure water flow in helical tubes with various helix diameters was simulated using the re-normalization group k–ε model to investigate the effects of finite-thickness walls, inlet mass flux, and helix diameter. The finite-thickness wall barely affected local heat transfer in the straight tube with inlet mass flux of 1,260 kg/(m2 s) whereas the local heat transfer in the helical tube was very different with relative difference in q/qav between the inside and bottom, caused by the centrifugal force, is 36%. In helical tubes, the heat transfer coefficients in the inner bar were the lowest, with a low fluid velocity under the effect of the centrifugal force. The buoyancy and centrifugal force in the helical tubes caused non-uniformity in the wall temperature; however, when the fluid temperature increased below the pseudo-critical temperature, the temperature distributions showed an increasing trend. The non-uniformities in the wall temperature distributions decreased as the centrifugal force increased, and they were suppressed by the finite-thickness wall.
Development of a biotic integrity index based on long-term fish assemblage changes after dam construction in China
Authors: Zhu Di , Yang Zhi , Chen Xiaojuan , Jin Yao , Li Dewang 
Published: February 2023

Multi-metric indicators based on fish assemblages have been widely applied to assess aquatic ecosystem biotic integrity. However, many of these were not detailed or standardized in metrics selection and reference status for a reservoir ecosystem under the long-term effects of hydro-electrical dam development. This makes it very difficult to determine the reference status and metrics because fish assemblages have been affected by human activities such as large reservoir operations. Based on long-term fish assemblage data, there were significant differences in fish composition between backwater and reservoir areas 10 years after the Three Gorges Reservoir (TGR) formation in China. We conducted this study to develop a new fish index of biotic integrity (IBI) to evaluate a large river reservoir ecosystem based on long-term monitoring data by establishing subregional habitat reference and selecting sensitive and concise metrics. In the Three Gorges Reservoir, we found that: 1) dynamic change is an important feature of fish assemblages in a relatively dynamic state after a decade of intensive disturbance caused by reservoir operations; 2) reference conditions for the reservoir evaluation should be selected in different stages for two different ecological habitats (lotic backwater and lentic reservoir reaches); 3) two core metrics and five sensitive metrics were selected to reflect fish assemblage degradation based on long term observations; and 4) overall fish biological integrity is generally “fair-poor,” in the reservoir area it is “fair” and “poor,” and in the reservoir lotic backwater it is “fair.” The long-term effects of large canyon reservoirs on biological integrity require long-term observation, and reasonable recovery targets should be set at different stages in reservoir management. In this study, a new biological integrity index was developed to screen and evaluate the ecological status of a semi-artificial reservoir ecosystem. Our results support reservoir biologically integrated management and green sustainable development goals.