bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equipment Repositories for Accessibility: A Model for Improving Access in Field Science
Authors: Devitz Amy-Charlotte 
Published: May 2023

SynopsisPeople with disabilities have been historically underrepresented in scientific fields as a result of systemic barriers and a “leaky pipeline” through academia. This has been especially true in field science, where a lack of resources and limited access to adaptive equipment have made accommodating disabilities in field settings seem daunting. This paper introduces the Equipment Repositories for Accessibility (ERA) model as a blueprint for universities to implement and improve the accessibility of field research and field-based courses. It first provides an overview of the history of disability in science and how systemic barriers contribute to underrepresentation and reduced access to field science. It then outlines the steps for the establishment and long-term management of the ERA model as a means of overcoming these barriers and provides a brief overview of the types of adaptive equipment available for a diverse range of accessibility needs. The scientific community benefits from the inclusion of diverse individuals and addressing barriers to accessibility is a necessary step in creating a truly intersectional academic community, which acknowledges the deeply interconnected nature of disability with other identities including race, gender, and sexuality.
IDEA+ and OBFS: Using Transdisciplinary Strategies to Create More Inclusive Spaces
Authors: McDermott Victoria , Roketenetz Lara D , Jekielek Phoebe , Struminger Rhonda 
Published: May 2023

SynopsisProfessional societies play a unique role in our personal and professional lives as spaces for connection and as regulatory entities. Often composed of volunteers from a variety of backgrounds, professional societies can guide the cultural norms and expectations of an industry by acting as critical leaders for supporting diversity, equity, and inclusion initiatives. The present manuscript explains how professional societies, like the Organization of Biological Field Stations (OBFS), can embrace transdisciplinary approaches to create more inclusive (in)tangible spaces to address serious problems facing industries today. Climate change, sexism, and racism, are examples of “wicked” problems that cannot be solved using existing modes of inquiry and decision making because of their complex and interrelated nature. As members of OBFS, a professional society dedicated to the advancement of field-based research, we explain how transdisciplinarity can and has been used to begin addressing serious issues like racism and sexism in field-based research and provide steps for future professional societies to engage in transdisciplinary thinking. We close with examples of our own transdisciplinary work developed through our membership within OBFS.
Zero-truncated Poisson regression for sparse multiway count data corrupted by false zeros
Authors: López Oscar F , Dunlavy Daniel M , Lehoucq Richard B 
Published: May 2023

Abstract
We propose a novel statistical inference methodology for multiway count data that is corrupted by false zeros that are indistinguishable from true zero counts. Our approach consists of zero-truncating the Poisson distribution to neglect all zero values. This simple truncated approach dispenses with the need to distinguish between true and false zero counts and reduces the amount of data to be processed. Inference is accomplished via tensor completion that imposes low-rank tensor structure on the Poisson parameter space. Our main result shows that an $N$-way rank-$R$ parametric tensor $\boldsymbol{\mathscr{M}}\in (0,\infty )^{I\times \cdots \times I}$ generating Poisson observations can be accurately estimated by zero-truncated Poisson regression from approximately $IR^2\log _2^2(I)$ non-zero counts under the nonnegative canonical polyadic decomposition. Our result also quantifies the error made by zero-truncating the Poisson distribution when the parameter is uniformly bounded from below. Therefore, under a low-rank multiparameter model, we propose an implementable approach guaranteed to achieve accurate regression in under-determined scenarios with substantial corruption by false zeros. Several numerical experiments are presented to explore the theoretical results.
Stabilization of the Pendubot: a polynomial matrix approach
Authors: Wei Cui , Vardulakis Antonis , Chai Tianyou 
Published: May 2023

Abstract
This paper concerns the stabilization problem for an underactuated robot called the Pendubot. Relying on a computational algorithm which is based on various results of the ‘polynomial matrix approach’, we propose an output-feedback-based internally stabilizing controller to stabilize the Pendubot at the unstable vertical upright position. The algorithm utilizes results for the solution of polynomial matrix Diophantine equations required for the computation and parameterization of proper ‘denominator assigning’ and internally stabilizing controllers for linear time invariant multivariable systems and reduces the problem to that of the solution of a set of numerical linear equations. The controller presented uses only the measured output which consists of the angles of the two links and does not require knowledge of the angular velocities which are usually not directly measurable. Comparative simulations are carried out to verify the good performance of the proposed controller. Finally, experimental results are provided to demonstrate the validity and feasibility of the proposed method.
Differential effects of size-specific particulate matter on frailty transitions among middle-aged and older adults in China: findings from the China Health and Retirement Longitudinal Study (CHARLS), 2015–2018
Authors: Guo Zhen , Xue Hui , Fan Lijun , Wu Di , Wang Yiming , Chung Younjin , Liao Yilan , Ruan Zengliang , Du Wei 
Published: May 2023

Abstract

Background
This study aimed to assess the long-term effects of size-specific particulate matter (PM) on frailty transitions in middle-aged and older Chinese adults.

Methods
We included 13 910 participants ≥45 y of age from the China Health and Retirement Longitudinal Study (CHARLS) for 2015 and 2018 who were classified into three categories in 2015 according to their frailty states: robust, prefrail and frail. Air quality data were obtained from the National Urban Air Quality Real-time Publishing Platform. A two-level logistic regression model was used to examine the association between concentrations of PM and frailty transitions.

Results
At baseline, the total number of robust, prefrail and frail participants were 7516 (54.0%), 4324 (31.1%) and 2070 (14.9%), respectively. Significant associations were found between PM concentrations and frailty transitions. For each 10 μg/m3 increase in the 3-y averaged 2.5-μm PM (PM2.5) concentrations, the risk of worsening in frailty increased in robust (odds ratio [OR] 1.06 [95% confidence interval {CI} 1.01 to 1.12]) and prefrail (OR 1.07 [95% CI 1.01 to 1.13]) participants, while the probability of improvement in frailty in prefrail (OR 0.91 [95% CI 0.84 to 0.98]) participants decreased. In addition, the associations of PM10 and coarse fraction of PM with frailty transitions showed similar patterns.

Conclusions
Long-term exposure to PM was associated with higher risks of worsening and lower risks of improvement in frailty among middle-aged and older adults in China.
Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network
Authors: Andrew Melissa K , Pott Henrique , Staadegaard Lisa , Paget John , Chaves Sandra S , Ortiz Justin R , McCauley John , Bresee Joseph , Nunes Marta C , Baumeister Elsa , Raboni Sonia Mara , Giamberardino Heloisa I G , McNeil Shelly A , Gomez Doris , Zhang Tao , Vanhems Philippe , Koul Parvaiz A , Coulibaly Daouda , Otieno Nancy A , Dbaibo Ghassan , Almeida Maria Lourdes Guerrero , Laguna-Torres Victor Alberto , Drăgănescu Anca Cristina , Burtseva Elena , Sominina Anna , Danilenko Daria , Medić Snežana , Diez-Domingo Javier , Lina Bruno 
Published: May 2023

Abstract

Background
The Global Influenza Hospital Surveillance Network (GIHSN) was established in 2012 to conduct coordinated worldwide influenza surveillance. In this study, we describe underlying comorbidities, symptoms, and outcomes in patients hospitalized with influenza.

Methods
Between November 2018 and October 2019, GIHSN included 19 sites in 18 countries using a standardized surveillance protocol. Influenza infection was laboratory-confirmed with reverse-transcription polymerase chain reaction. A multivariate logistic regression model was utilized to analyze the extent to which various risk factors predict severe outcomes.

Results
Of 16 022 enrolled patients, 21.9% had laboratory-confirmed influenza; 49.2% of influenza cases were A/H1N1pdm09. Fever and cough were the most common symptoms, although they decreased with age (P &lt; .001). Shortness of breath was uncommon among those &lt;50 years but increased with age (P &lt; .001). Middle and older age and history of underlying diabetes or chronic obstructive pulmonary disease were associated with increased odds of death and intensive care unit (ICU) admission, and male sex and influenza vaccination were associated with lower odds. The ICU admissions and mortality occurred across the age spectrum.

Conclusions
Both virus and host factors contributed to influenza burden. We identified age differences in comorbidities, presenting symptoms, and adverse clinical outcomes among those hospitalized with influenza and benefit from influenza vaccination in protecting against adverse clinical outcomes. The GIHSN provides an ongoing platform for global understanding of hospitalized influenza illness.
The Impact of Antimicrobial Therapy Duration in the Treatment of Prosthetic Joint Infections Depending on Surgical Strategies: A Systematic Review and Meta-analysis
Authors: Olearo Flaminia , Zanichelli Veronica , Exarchakou Aimilia , Both Anna , Uςkay Ilker , Aepfelbacher Martin , Rohde Holger 
Published: May 2023

Abstract
The aim of this systematic review was to address the question if short antibiotic treatment (SAT; at least 4 but &lt;12 weeks) versus long antibiotic treatment (LAT) affects outcomes in prosthetic joint infections (PJIs). Database research (Medline, Embase, Web of Science, Scopus, Cochrane) retrieved 3740 articles, of which 10 studies were included in the analysis. Compared to LAT, 11% lower odds of treatment failure in the SAT group were found, although the difference was not statistically significant (pooled odds ratio, 0.89 [95% confidence interval, .53–1.50]). No difference in treatment failure was found between SAT and LAT once stratified by type of surgery, studies conducted in the United States versus Europe, study design, and follow-up. There is still no conclusive evidence that antibiotic treatment of PJIs for 12 weeks or longer is associated with better outcomes, irrespective of the type of surgical procedure. Most recent, high-quality studies tend to favor longer antibiotic courses, making them preferable in most situations.
Bioactive mineralized small intestinal submucosa acellular matrix/PMMA bone cement for vertebral bone regeneration
Authors: Miao Xinbao , Yang Shuhui , Zhu Jinjin , Gong Zhe , Wu Dongze , Hong Juncong , Cai Kaiwen , Wang Jiying , Fang Xiangqian , Lu Jiye , Jiang Guoqiang 
Published: May 2023

Abstract
Polymethylmethacrylate (PMMA) bone cement extensively utilized for the treatment of osteoporotic vertebral compression fractures due to its exceptional handleability and mechanical properties. Nevertheless, the clinical application of PMMA bone cement is restricted by its poor bioactivity and excessively high modulus of elasticity. Herein, mineralized small intestinal submucosa (mSIS) was incorporated into PMMA to prepare a partially degradable bone cement (mSIS–PMMA) that provided suitable compressive strength and reduced elastic modulus compared to pure PMMA. The ability of mSIS–PMMA bone cement to promote the attachment, proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells was shown through cellular experiments carried out in vitro, and an animal osteoporosis model validated its potential to improve osseointegration. Considering these benefits, mSIS–PMMA bone cement shows promising potential as an injectable biomaterial for orthopedic procedures that require bone augmentation.
Relationship between mechanical load and surface erosion degradation of a shape memory elastomer poly(glycerol-dodecanoate) for soft tissue implant
Authors: Jin Kaixiang , Li Hanqin , Liang Mingkai , Li Yuqi , Wang Lizhen , Fan Yubo 
Published: May 2023

Abstract
Poly(glycerol-dodecanoate) (PGD) has aroused increasing attention in biomedical engineering for its degradability, shape memory and rubber-like mechanical properties, giving it potential to fabricate intelligent implants for soft tissues. Adjustable degradation is important for biodegradable implants and is affected by various factors. The mechanical load has been shown to play an important role in regulating polymer degradation in vivo. An in-depth investigation of PGD degradation under mechanical load is essential for adjusting its degradation behavior after implantation, further guiding to regulate degradation behavior of soft tissue implants made by PGD. In vitro degradation of PGD under different compressive and tensile load has proceeded in this study and describes the relationships by empirical equations. Based on the equations, a continuum damage model is designed to simulate surface erosion degradation of PGD under stress through finite element analysis, which provides a protocol for PGD implants with different geometric structures at varied mechanical conditions and provides solutions for predicting in vivo degradation processes, stress distribution during degradation and optimization of the loaded drug release.
Incidence and Risk Profiles for Suicide Mortality in Patients With Schizophrenia Receiving Homecare Case Management in Taiwan
Authors: Chen Wen-Yin , Pan Chun-Hung , Su Sheng-Shiang , Yang Tien-Wei , Chen Chiao-Chicy , Kuo Chian-Jue 
Published: May 2023

Abstract
Case management (CM)-based community therapy for patients with schizophrenia had little effect on reducing suicide mortality. We investigate the long-term suicide mortality outcome and associated risk factors in patients with schizophrenia receiving homecare (CM) in Taiwan. We enrolled a nationwide cohort of patients with schizophrenia who newly received homecare CM intervention (n = 13 317) between January 1, 2001, and December 31, 2015; their data were derived from Taiwan’s National Health Insurance Research Database. We calculated the incidence rate of suicide methods. We examined the demographic and medical utilization profile for suicide and then performed a nested case–control study and multivariate regression to identify independent risk factors for suicide mortality. Among the 13 317 patients who received homecare CM intervention, 1766 died during the study period, of whom 213 died by suicide, which is the leading cause of unnatural death. Jumping from a high place, self-poisoning, and hanging were the top 3 suicide methods. Increased medical utilization was noted for both psychiatric and non-psychiatric services within 3 months of suicide mortality. Comorbidities of depressive disorder, nonspecific heart diseases, pneumonia, and gastrointestinal ulcers were identified as independent risk factors for suicide mortality. Suicide was the leading cause of unnatural mortality in patients with schizophrenia receiving homecare CM intervention in Taiwan. We noted the preferred suicide methods, high medical utilization, and comorbidities before suicide. Thus, we suggest that the CM team should assess lethal methods for suicide and ensure that patients adhere to psychiatry treatment for improving the current care model for this specified population.
Risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses: an electronic health record-based analysis from the RECOVER initiative
Authors: L Mandel Hannah , Colleen Gunnar , Abedian Sajjad , Ammar Nariman , Charles Bailey L , Bennett Tellen D , Daniel Brannock M , Brosnahan Shari B , Chen Yu , Chute Christopher G , Divers Jasmin , Evans Michael D , Haendel Melissa , Hall Margaret A , Hirabayashi Kathryn , Hornig Mady , Katz Stuart D , Krieger Ana C , Loomba Johanna , Lorman Vitaly , Mazzotti Diego R , McMurry Julie , Moffitt Richard A , Pajor Nathan M , Pfaff Emily , Radwell Jeff , Razzaghi Hanieh , Redline Susan , Seibert Elle , Sekar Anisha , Sharma Suchetha , Thaweethai Tanayott , Weiner Mark G , Jae Yoo Yun , Zhou Andrea , Thorpe Lorna E 
Published: May 2023

Abstract

Study Objectives
Obstructive sleep apnea (OSA) has been associated with more severe acute coronavirus disease-2019 (COVID-19) outcomes. We assessed OSA as a potential risk factor for Post-Acute Sequelae of SARS-CoV-2 (PASC).

Methods
We assessed the impact of preexisting OSA on the risk for probable PASC in adults and children using electronic health record data from multiple research networks. Three research networks within the REsearching COVID to Enhance Recovery initiative (PCORnet Adult, PCORnet Pediatric, and the National COVID Cohort Collaborative [N3C]) employed a harmonized analytic approach to examine the risk of probable PASC in COVID-19-positive patients with and without a diagnosis of OSA prior to pandemic onset. Unadjusted odds ratios (ORs) were calculated as well as ORs adjusted for age group, sex, race/ethnicity, hospitalization status, obesity, and preexisting comorbidities.

Results
Across networks, the unadjusted OR for probable PASC associated with a preexisting OSA diagnosis in adults and children ranged from 1.41 to 3.93. Adjusted analyses found an attenuated association that remained significant among adults only. Multiple sensitivity analyses with expanded inclusion criteria and covariates yielded results consistent with the primary analysis.

Conclusions
Adults with preexisting OSA were found to have significantly elevated odds of probable PASC. This finding was consistent across data sources, approaches for identifying COVID-19-positive patients, and definitions of PASC. Patients with OSA may be at elevated risk for PASC after SARS-CoV-2 infection and should be monitored for post-acute sequelae.
Cadmium-induced stress: a close look at the relationship between autophagy and apoptosis
Authors: Tuffour Alex , Adebayiga Kosiba Anthony , Addai Peprah Frank , Gu Jie , Zhou Yang , Shi Haifeng 
Published: May 2023

AbstractStress is acknowledged as one of the major factors responsible for autophagy induction, a tightly regulated process that acts as a pro-death or pro-survival mechanism within cells. Cadmium (Cd), a toxic heavy metal, induces apoptosis and autophagy in cells after exposure to low concentrations. This is due to Cd’s ability to induce oxidative stress in cells and tissues by overproducing reactive oxygen species. Several proteins have been found to mediate the process of autophagy but aspects of their specific roles and targets remain undefined. Though LC3-II and p62 have traditionally been used as biomarkers that define autophagy, recent findings have revealed some limitations to LC3-II because it can be accumulated in cells in an autophagy-independent manner, whereas p62 remains a good determinant of the process. In addition to LC3-II and p62, recent studies have suggested that a new member of the autophagy protein family, the vacuole membrane protein 1 (VMP1), is essential in driving autophagy and could be an important biomarker for detecting the initiation and progression of autophagy. This review therefore focuses on current trends in autophagy biomarkers, the effect of Cd on the expression of LC3-II, p62, VMP1, and Beclin-1 and their relation and inter-regulatory roles in autophagy and apoptosis, pharmacological importance, and the mechanisms involved.
Textbook outcome in gallbladder carcinoma after curative-intent resection: a 10-year retrospective single-center study
Authors: Li Qi , Liu Hengchao , Gao Qi , Xue Feng , Fu Jialu , Li Mengke , Yuan Jiawei , Chen Chen , Zhang Dong , Geng Zhimin 
Published: May 2023

Abstract

Background:
Textbook outcome (TO) can guide decision-making among patients and clinicians during preoperative patient selection and postoperative quality improvement. We explored the factors associated with achieving a TO for gallbladder carcinoma (GBC) after curative-intent resection and analyzed the effect of adjuvant chemotherapy (ACT) on TO and non-TO patients.

Methods:
A total of 540 patients who underwent curative-intent resection for GBC at the Department of Hepatobiliary Surgery of the First Affiliated Hospital of Xi'an Jiaotong University from January 2011 to December 2020 were retrospectively analyzed. Multivariable logistic regression was used to investigate the factors associated with TO.

Results:
Among 540 patients with GBC who underwent curative-intent resection, 223 patients (41.3%) achieved a TO. The incidence of TO ranged from 19.0% to 51.0% across the study period, with a slightly increasing trend over the study period. The multivariate analysis showed that non-TO was an independent risk factor for prognosis among GBC patients after resection (P =0.003). Age ≤60 years (P =0.016), total bilirubin (TBIL) level ≤34.1 μmol/L (P <0.001), well-differentiated tumor (P =0.008), no liver involvement (P <0.001), and T1–2 stage disease (P =0.006) were independently associated with achieving a TO for GBC after resection. Before and after propensity score matching (PSM), the overall survival outcomes of non-TO GBC patients who received ACT and those who did not were statistically significant; ACT improved the prognosis of patients in the non-TO group (P <0.050).

Conclusion:
Achieving a TO is associated with a better long-term prognosis among GBC patients after curative-intent resection, and ACT can improve the prognosis of those with non-TO.
Medication Safety Event Reporting
Authors: Cohen Tara N. , Berdahl Carl T. , Coleman Bernice L. , Seferian Edward G. , Henreid Andrew J. , Leang Donna W. , Nuckols Teryl K. 
Published: May 2023

Background:
Incident reports submitted during times of organizational stress may reveal unique insights.

Purpose:
To understand the insights conveyed in hospital incident reports about how work system factors affected medication safety during a coronavirus disease-2019 (COVID-19) surge.

Methods:
We randomly selected 100 medication safety incident reports from an academic medical center (December 2020 to January 2021), identified near misses and errors, and classified contributing work system factors using the Human Factors Analysis and Classification System-Healthcare.

Results:
Among 35 near misses/errors, incident reports described contributing factors (mean 1.3/report) involving skill-based errors (n = 20), communication (n = 8), and tools/technology (n = 4). Reporters linked 7 events to COVID-19.

Conclusions:
Skill-based errors were the most common contributing factors for medication safety events during a COVID-19 surge. Reporters rarely deemed events to be related to COVID-19, despite the tremendous strain of the surge on nurses. Future efforts to improve the utility of incident reports should emphasize the importance of describing work system factors.