bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 457: Utilizing the Comaneci Device for Dural Venous Sinus Thrombectomy
Authors: Kim V. , Abramyan A. , Berezovsky D. , Afridi M. , Sozio S. , Gupta G. , Roychowdhury S. , Sundararajan S. 
Published: January 2025

Purpose:
The treatment of dural venous sinus (DVS) thrombosis is anticoagulation. In select patients, thrombectomy or thrombolysis can be considered based on clinical status. The following case demonstrates the potential benefits of an off‐label application of the Comaneci device for DVS thrombectomy.

Case:
A 47‐year‐old female patient presented with right‐sided weakness, nausea, and vomiting. Imaging revealed thrombosis of the superior sagittal sinus (SSS) extending to the torcula, right transverse sinus (TS), and right sigmoid sinus (SS) with a hemorrhagic venous infarct in the left parietal lobe. The patient was started on anticoagulation. However, her symptoms worsened with repeat imaging showing a new left frontal lobe hemorrhagic infarct. The decision was made to proceed with mechanical thrombectomy. Arterial and venous access was obtained in the right groin. Angiography showed venous sinus thrombosis of most of the SSS and torcula with focal occlusion of the right TS. A Zoom 71TM catheter was advanced into the anterior SSS. Pharmacomechanical thrombolysis was performed using a Scepter balloon that was intermittently inflated along the SSS while 5 mg tPA was infused. This yielded minimal improvement. Therefore a combination of mechanical thrombectomy using a Comaneci 21 device and aspiration thrombectomy using a Zoom 88TM catheter was performed in the SSS torcula, and right TS. The rapid inflation‐deflation (RID) technique of fast cycling the expansion and closure of the Comaneci over a period of time allowed for dislodgment of hard thrombus while concurrent aspiration of dislodged thrombus into the Zoom 71 intermediate and Zoom 88 guide catheters was employed. Post‐treatment angiogram confirmed resolution of occlusive thrombus with improved rate of angiographic arterial to capillary phase transgression. Only small volume non‐occlusive thrombus in the SSS, right TS, and right SS remained.

Result:
The patient was continued on therapeutic systemic anticoagulation post‐procedure. Follow‐up imaging showed stable left parietal and frontal lobe infarcts with stable hemorrhage and near‐complete resolution of prior DVS thrombus. She was discharged on hospital day 6.

Conclusion
Multiple endovascular techniques for DVS thrombosis have been described, which include aspiration, angioplasty, and lysis. To our knowledge, this is the first reported use of the Comaneci device for the treatment of DVS thrombosis. Following suboptimal results from balloon‐assisted thrombolysis, we used the Comaneci device and RID technique to actively macerate hard thrombus and allow for more effective aspiration. The Comaneci device is typically utilized with cerebral aneurysm coiling interventions or treatment of intracranial arterial vasospasm. Our case demonstrates a novel approach of rapid inflation‐deflation utilizing the Comaneci device for a successful DVS thrombectomy.
1. Why do we learn statistics
Authors: Navarro Danielle , Foxcroft David 
Published: January 2025

This chapter introduces the critical role of statistics in psychological and social sciences, emphasizing its importance despite students’ frequent apprehension toward the subject. Statistics is central to science because it serves as a safeguard against the biases and fallibilities inherent in human reasoning. The chapter begins by addressing common questions about why scientists rely so heavily on statistical methods, explaining that human intuition, while valuable, is unreliable for evaluating evidence impartially. Examples such as belief bias in logical reasoning illustrate how pre-existing beliefs can cloud judgment, making statistical tools essential for uncovering objective truths. Through examples like Simpson's Paradox, the chapter highlights the counterintuitive traps in data interpretation that necessitate a structured, statistical approach. Statistics is positioned not just as a technical tool, but as a vital instrument to navigate the complexities of human behavior and social phenomena.
The chapter also extends its discussion to the broader context of research methods, underscoring that while statistics is fundamental, it is only one part of the methodological toolbox. In the sciences robust statistical literacy is essential to ensure rigour in research design and data interpretation. The chapter concludes with a reflection on the universality of statistical principles across various types of research while acknowledging the domain-specific nuances of research design. Ultimately, it advocates for statistics as both a practical necessity for academic success and a critical life skill in an increasingly data-driven world, dispelling fears and misconceptions about its complexity and relevance.
3. Getting started with jamovi
Authors: Navarro Danielle , Foxcroft David 
Published: January 2025

Chapter 3 of the book introduces readers to the statistical software jamovi, guiding them through the initial steps of downloading, installing, and familiarising themselves with its interface. The chapter emphasises the advantages of using jamovi for statistical analysis, including its user-friendly design, compatibility with the R statistical programming language, and open-source nature, which helps avoid the constraints of costly proprietary software. A significant portion of the chapter is devoted to exploring jamovi’s graphical user interface, with explanations on managing datasets, working with variables, and understanding the program's layout. Readers are introduced to basic operations such as entering data, importing various file formats, and using jamovi's features to manipulate and configure variables.
In addition, the chapter highlights practical aspects like installing add-on modules, handling uncommon data file formats, and saving work effectively. It also discusses the benefits of jamovi's APA-styled outputs, its integration with R syntax, and its utility for computed variables, making it a powerful tool for data analysis. While the focus remains on operational familiarity rather than statistical concepts, the chapter lays a robust foundation for users to navigate jamovi confidently and prepares them for subsequent chapters that delve deeper into statistical methodologies and analyses.
14. Factorial ANOVA
Authors: Navarro Danielle , Foxcroft David 
Published: January 2025

Chapter 14 explores the extension of ANOVA to factorial designs, allowing for the analysis of data influenced by multiple categorical predictor variables. This chapter builds on previous concepts introduced in simpler ANOVA and regression models, integrating the use of factorial designs to examine interactions between factors. By employing examples such as the effects of gender and school on student reading comprehension, the chapter demonstrates how factorial ANOVA (specifically two-way ANOVA) provides insights into main effects and interactions between factors. It introduces balanced factorial designs and systematically guides the reader through hypothesis formulation, model interpretation, and statistical testing using jamovi. Detailed explanations of sums of squares, degrees of freedom, and how to compute F-statistics further demystify the underlying mechanics of factorial ANOVA.
Subsequent sections delve into practical applications, such as interpreting interaction effects and understanding the implications of significant main effects in the presence of interactions. The chapter also contrasts factorial ANOVA with regression, highlighting their equivalence in linear modeling. It addresses complex scenarios, such as unbalanced designs, by examining different hypothesis testing strategies, including Type I, II, and III sum of squares. Through visual aids, practical examples, and clear step-by-step analyses, this chapter equips readers with the theoretical and practical tools necessary to perform and interpret factorial ANOVA effectively, fostering a deeper understanding of its power and versatility in experimental research.
Fostering innovation in smart library services: An in-depth exploration of empowered capabilities and dynamic strategies among university librarians in Pakistan
Authors: Aslam Sanila , Jabeen Munazza , Jabeen Misbah 
Published: January 2025

Purpose The need to implement innovative smart services in libraries is becoming more widely recognized. This paper investigates the current status of innovation in smart library services, how university librarians can support innovation in library services through their capacities and dynamic strategies, the implications that innovative initiatives have on overall effectiveness, and the challenges that university librarians perceive. Methodology A mixed-method approach was employed in this study. In the qualitative method, in-depth interviews were conducted with 10 chief librarians of university libraries and 150 university library professionals made up the sample for the quantitative investigation from throughout Pakistan. Findings The provision of smart services is clearly in the plans for the growth of university libraries in Pakistan, and the majority of university librarians also discuss the challenges in implementing innovations and provide solutions to these problems. The study uncovers significant barriers to adopting innovative library services, such as the fear of job displacement due to technology and financial constraints. However, it underscores the potential of focused training, AI, and IoT technologies to enhance library services. Originality These advancements can boost user engagement and operational efficiency and are crucial for aligning library services with global educational and sustainability goals. The research stresses the need for strategic planning and investment in financing and infrastructure, advocating that these measures can enhance educational outcomes and reduce information access disparities, thereby benefiting the entire community.
The appropriateness of self-care policy for urinary tract infections among women from racialised minorities and low-income households in the United Kingdom: A qualitative study
Authors: Pacho Agata , Mays Nicholas , Glover Rebecca E 
Published: January 2025

Objectives Urinary tract infections (UTIs) can negatively impact quality of life, especially when recurring. Patients often seek medical advice to relieve painful symptoms. UTIs are also the second most common reason antibiotics are prescribed in English primary care. However, overuse and long-term use of antibiotics for suspected UTIs in women can lead to antibiotic-resistant bacteria, making future treatments less effective. The UK’s 2019-24 Antimicrobial Resistance National Action Plan aims to raise public awareness about the risks of overusing antibiotics and encourages self-care for minor infections, like uncomplicated UTIs. We explored how feasible and appropriate this approach is. Methods The transcripts from four online focus groups and 19 one-to-one online interviews involving 25 racialised minority and/or low-income women were analysed thematically. Meetings with lay members of the public with similar socio-demographics and experiences to those we planned on recruiting for the research helped to orientate the study, refine its materials and enhance its recruitment strategies. Results All participants spoke about UTI-related anxieties, which they experienced differently depending on the frequency and the course of UTI episodes, and how knowledgeable they were about the symptoms. Participants often practised self-care for UTIs before seeking professional advice. They saw consultations with health care professionals as valuable for managing the symptoms of UTIs and navigating self-care options. Those with recurrent UTIs felt they could recognise when they required antibiotics and, therefore, they felt they could take responsibility for minimising overprescribing. Barriers to self-care included high pressure working days and not being able to take time off work to recover. Conclusions Participants in our study were often able to self-diagnose and assess the severity of their symptoms, which makes them partners in efforts to improve antibiotic stewardship. They still valued consulting professionals for advice and support about their UTIs, irrespective of whether they received a prescription.
Pulmonary rehabilitation healthcare professionals understanding and experiences of the protected characteristics of service users: A qualitative analysis
Authors: Drover Holly , Singh Sally J , Orme Mark W , Daynes Enya 
Published: January 2025

Background Health inequalities can affect access and uptake to pulmonary rehabilitation (PR). An individual’s protected characteristics (age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex and sexual orientation) may contribute to health inequalities. Healthcare professionals (HCPs) experiences of the inclusivity and representativeness of PR services and knowledge of protected characteristics are unknown, however are vital for the identification and resolution of health inequalities. This qualitative study explored HCPs understanding of protected characteristics and their perception of the inclusivity, representativeness and equitable benefit of their PR services. Methods Semi-structured qualitative interviews were conducted in person or via videoconferencing with HCPs involved in PR from two healthcare providers. Interviews were analysed using reflexive thematic analysis. Results 12 interviews were conducted with physiotherapists ( n = 6), occupational therapists ( n = 2), nurses ( n = 2) and exercise physiologists ( n = 2). Participants had a median (IRQ) age of 43 (13) and 75% ( n = 9) were female. Four themes were generated. 1: ‘I don’t really know as much as I should’ [about protected characteristics]; 2: It’s uncomfortable collecting protected characteristics…; 3: ‘I don’t think [service users] are as representative as they could be’; 4: A conventional rehabilitation programme does not meet the needs of all. Conclusions This study highlighted several challenges in HCPs understanding of protected characteristics and the representativeness of PR that must be addressed to ensure equity. Strategies, to understand barriers in accessing PR that limit representativeness should be explored.
Hybrid Arch Aneurysm Repair With Ascending Aortic Wrap and TEVAR
Authors: Shazly Omar El , Porez Florent , Ramadan Ramzi , Le Houérou Thomas , Gaudin Antoine , Costanzo Alessandro , Fabre Dominique , Guihaire Julien , Haulon Stéphan 
Published: January 2025

Introduction: Management of patients with large aortic arch aneurysms who are considered high risk for frozen elephant trunk technique have been challenging, especially when they have a dilated ascending aorta (AA) that precludes total endovascular branched repair (arch BEVAR). A viable option in our armamentarium is wrapping of the AA (AW), and zone 0 Ishimaru TEVAR. Methods: Retrospective analysis of our aortic database from 2013 to 2024 to select high-risk patients with aortic arch aneurysm that had an AW and TEVAR. We performed CTA analysis before and after wrapping and TEVAR, and last available CTA. The primary end points were 30-day mortality and stroke. Results: A total of 12 patients had AA wrap and TEVAR, with supra-aortic vessels (SAVs) debranching (open or endovascular). In 9 patients, the indication for treatment was a large arch atherosclerotic aneurysm, and in 3 patients a dissecting arch aneurysm depicted during follow-up of AW initially performed for acute type A dissection (51.5 months on average between the wrap and the TEVAR). Average age was 72.9 years. Ascending aorta wrap and TEVAR were performed concomitantly in 3/12 patients, including 2 patients with rupture. It was staged in the other 9 patients. The average diameter of the AA pre-wrap was 47.7 (41.3-57), and post-wrap 35.6 (31.9-43) mm. The wrap provided an average seal length of 68.5 (38.4-97.4) mm. A total of 34 SAV were successfully debranched. No type 1 or 3 endoleaks were depicted on completion angiogram. Within the first 30 days, no strokes were diagnosed, and 1 patient with Horton disease died of cardiac arrest on postoperative day 7. Three patients required early reinterventions, including redosternotomy in 2 patients. Mean follow-up (FU) was 28 months (1-75). During FU, 1 patient developed a left vertebral artery steal phenomenon requiring a carotid subclavian bypass, and another patient died of an unknown cause. Conclusion: Ascending aorta wrap technique with debranching of the SAVs and zone 0 TEVAR might be a good option in patients at high risk for open replacement of the AA and with unfavorable proximal seal zone for a total endovascular repair. Clinical Impact In the current study, we describe the treatment of aortic arch aneurysms in patients considered at high risk for open replacement of the aortic arch and also not candidate for complete endovascular arch repair (arch BEVAR). Ascending aorta wrap with surgical or endovascular debranching of SAVs and zone 0 TEVAR was performed in 12 patients with favorable outcomes. It should thus be considered a treatment option in this subset of fragile patients with unfavorable proximal seal zone for total endovascular repair. This technique does not require cardiopulmonary bypass (CPB) support, neither aortic cross-clamping
Translation, Cross-Cultural Adaptation, and Validation of the Kannada Version of the Exercise Adherence Rating Scale (EARS-Kn) Among Head and Neck Cancer (HNC) Survivors in a Tertiary Care Setup in India
Authors: Pai Hritika D. , Kumar K Vijaya , Mithra Prasanna , Samuel Stephen Rajan , Athiyamaan Mariappan Senthiappan , Godfrey Emma Louise 
Published: January 2025

Background: Adherence in rehabilitation services includes attending appointments, regularly performing prescribed exercises, and correct exercise execution. The Exercise Adherence Rating Scale (EARS) has been adapted into several languages, but there is lack of a standardized tool for various Indian languages and cultural contexts, particularly for use with cancer survivors. With the anticipated 57.7% rise in cancer cases by 2040, this study aims to address this gap. Aims and objectives: To cross-culturally adapt EARS to Kannada (EARS-Kn) and evaluate its validity and reliability amongst HNC survivors enrolled in the Multimodal Oncology Rehabilitation Exercise—MORE© Program. Methodology: Following Beaton guidelines, the EARS tool was adapted to Kannada. 34 HNC survivors engaged in the MORE© program. Internal consistency (Cronbach’s ⍺) and construct validity (Exploratory Factor Analysis, EFA) were assessed. The Receiver Operating Curve (ROC) determined cut-off scores, sensitivity and specificity of the EARS-Kn. Results: The EARS-Kn demonstrated a Cronbach’s-⍺ value of .93. The EFA revealed a one-factor solution with eigenvalues exceeding one and 70.1% loading. The area under the curve (AUC) was 0.908. A cut-off score of 17 was established, with 95.83% sensitivity and 80% specificity. Conclusion: The EARS-Kn version showed strong validity and reliability among Kannada-speaking HNC survivors, indicating its potential to enhance the understanding of exercise adherence among them. Future studies could explore the EARS-Kn version among diverse populations prescribed various rehabilitation regimes. Studies could also further investigate psychometric properties of the EARS in different Indian languages among cancer survivors, which would help improve survivorship outcomes.
Estimation of and clinical consensus on the meaningful motor progression threshold on MDS-UPDRS Part III
Authors: Trundell Dylan , Davies Evan W. , Barrett Louise , Zanigni Stefano , Shariati Nima , Rogers Rebecca , Monnet Annabelle , Moore Emma , Pross Nathalie , Pagano Gennaro , Cano Stefan , Nikolcheva Tania 
Published: January 2025

Background To understand changes in the underlying progression of early Parkinson's disease, it is important to derive estimates of the threshold for meaningful motor progression on the MDS-UPDRS Part III in OFF medication state. Objective To estimate this threshold using two approaches: anchor-based analyses, and clinical consensus via a modified Delphi panel. Methods For the anchor-based analyses, data from a Phase II clinical trial were used. Mean and median MDS-UPDRS Part III change scores were calculated for those participants rated as ‘Minimally worse’ on the Clinical Global Impression of Improvement (using the first visit rated as ‘Minimally worse’ or worse, and at Weeks 24 and 52). Cumulative data up to Week 104 were used to assess the difference between motor progressors’ and non-progressors’ change scores on motor-related outcomes. For the modified Delphi panel, a panel of 13 expert clinicians received an online survey in two rounds and provided responses anonymously. Results For the anchor-based analyses, estimates of meaningful change ranged from 4−6 points. Numerically worse change scores were identified on motor-related outcomes for participants who had experienced motor progression compared with those who had not. For the modified Delphi panel, consensus was reached in Round 2, with 92% agreeing that 5 points is suitable to define a clinically meaningful motor progression threshold. Conclusions Results of the anchor-based analyses and modified Delphi panel were consistent, supporting a meaningful motor progression threshold of a worsening of 5 points on the MDS-UPDRS Part III (OFF medication state) in an early Parkinson's disease population.
Effects of 6 months of endurance exercise on motor function, exercise capacity, and autonomic function based on presence of autonomic dysfunction in individuals with early Parkinson's disease
Authors: Griffith Garett J , Mehta Niyati , Lamotte Guillaume , McKee Kathleen E , Suttman Erin , Haus Jacob M , Joslin Elizabeth , Balfany Katherine , Kohrt Wendy M , Christiansen Cory L , Melanson Edward L , Chahine Lana M , Christou Demetra D , Patterson Charity G , Corcos Daniel M 
Published: January 2025

Background Endurance exercise improves aerobic capacity (VO2peak) and motor symptoms in people with early Parkinson's disease (PD). Some people with PD exhibit signs of chronotropic incompetence (CI), which may impact exercise-induced benefits. Objective We investigated whether CI in people with early PD influences the change in motor signs, VO2peak, and peak heart rate (HR) following 6 months of endurance exercise. Methods We performed secondary analyses of the Study in Parkinson's Disease of Exercise (SPARX), which randomized people with early PD into a high-intensity endurance exercise [80–85% of peak HR], moderate-intensity endurance exercise [60–65% of peak HR], or usual care group. MDS-UDPRS Part 3 score, VO2peak, and heart rate (HR) response to maximal cardiopulmonary exercise testing (CPET) were analyzed at baseline and following 6 months of exercise. Participants were divided into three groups: 1) normal chronotropic response at baseline, 2) CI at baseline, and 3) taking medications with a known negative chronotropic effect regardless of CI status. Results Data from 119 individuals (64.0 ± 9.0 years, 57.1% male, 0.3 years since diagnosis [median]) were analyzed. There were no differences among the groups in change in MDS-UPDRS motor score ( p = 0.953), VO2peak ( p = 0.965), or peak HR ( p = 0.388). People randomized into the high-intensity group improved VO2peak compared to usual care ( p < 0.001adj) regardless of CI status. Conclusions Baseline CI did not alter responses to endurance exercise in those with early PD, suggesting that the beneficial effects of endurance exercise on disease progression and VO2peak in people with early PD apply equally to people with CI.