bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential drug targets for asthma identified in the plasma and brain through Mendelian randomization analysis
Authors: Wang Yuting , Wang Jiaxi , Yan Zhanfeng , Liu Siming , Xu Wenlong 
Published: September 2023

BackgroundAsthma is a heterogeneous disease, and the involvement of neurogenic inflammation is crucial in its development. The standardized treatments focus on alleviating symptoms. Despite the availability of medications for asthma, they have proven to be inadequate in controlling relapses and halting the progression of the disease. Therefore, there is a need for novel drug targets to prevent asthma.MethodsWe utilized Mendelian randomization to investigate potential drug targets for asthma. We analyzed summary statistics from the UK Biobank and then replicated our findings in GWAS data by Demenais et al. and the FinnGen cohort. We obtained genetic instruments for 734 plasma and 73 brain proteins from recently reported GWAS. Next, we utilized reverse causal relationship analysis, Bayesian co-localization, and phenotype scanning as part of our sensitivity analysis. Furthermore, we performed a comparison and protein–protein interaction analysis to identify causal proteins. We also analyzed the possible consequences of our discoveries by the given existing asthma drugs and their targets.ResultsUsing Mendelian randomization analysis, we identified five protein–asthma pairs that were significant at the Bonferroni level (P &lt; 6.35 × 10−5). Specifically, in plasma, we found that an increase of one standard deviation in IL1R1 and ECM1 was associated with an increased risk of asthma, while an increase in ADAM19 was found to be protective. The corresponding odds ratios were 1.03 (95% CI, 1.02–1.04), 1.00 (95% CI, 1.00–1.01), and 0.99 (95% CI, 0.98–0.99), respectively. In the brain, per 10-fold increase in ECM1 (OR, 1.05; 95% CI, 1.03–1.08) and PDLIM4 (OR, 1.05; 95% CI, 1.04–1.07) increased the risk of asthma. Bayesian co-localization found that ECM1 in the plasma (coloc.abf-PPH4 = 0.965) and in the brain (coloc.abf-PPH4 = 0.931) shared the same mutation with asthma. The target proteins of current asthma medications were found to interact with IL1R1. IL1R1 and PDLIM4 were validated in two replication cohorts.ConclusionOur integrative analysis revealed that asthma risk is causally affected by the levels of IL1R1, ECM1, and PDLIM4. The results suggest that these three proteins have the potential to be used as drug targets for asthma, and further investigation through clinical trials is needed.
Vitamin D, vitamin D supplementation and atrial fibrillation risk in the general population: updated systematic review and meta-analysis of prospective studies
Authors: Ding Xiaoli , Lai Jiying , Zhang Hehui , Guo Zongwen 
Published: September 2023

BackgroundSince the association of vitamin D with atrial fibrillation (AF) risk is still unclear, we conducted this updated meta-analysis of prospective studies to identify the relationship between vitamin D or vitamin D supplementation and AF in the general population.MethodsWe conducted a comprehensive search of multiple databases up to May 2023 for studies reporting vitamin D and AF. The hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled by a random-effects model.ResultsA total of seven studies were included in this meta-analysis. Vitamin D deficiency (&lt;20 ng/ml) was associated with increased AF incidence (HR: 1.12, 95% CI: 1.005–1.25). The HR was not significant with vitamin D insufficiency (20–30 ng/ml; HR: 1.09, 95% CI: 0.98–1.21). Each 10 ng/ml increase in serum vitamin D was associated with a significantly decreased AF incidence (HR: 0.95, 95% CI: 0.93–0.97). Two studies reported the effect of vitamin D supplements on AF incidence but reached inconsistent results.ConclusionsVitamin D deficiency or insufficiency was associated with an increased risk of AF in the general population. The role of vitamin D supplementation in AF prevention needs further investigation.
Expert opinions on informational and supportive needs and sources of obtaining information in patients with inflammatory bowel disease: a Delphi consensus study
Authors: Norouzkhani Narges , Bahari Ali , Shirvani Javad Shokri , Faramarzi Mahbobeh , Eslami Saeid , Tabesh Hamed 
Published: September 2023

BackgroundThe present study introduces informational and supportive needs and sources of obtaining information in patients with inflammatory bowel disease (IBD) through a three-round Expert Delphi Consensus Opinions method.MethodsAccording to our previous scoping review, important items in the area of informational and supportive needs and sources of obtaining information were elucidated. After omitting duplicates, 56 items in informational needs, 36 items in supportive needs, and 36 items in sources of obtaining information were retrieved. Both open- and close-ended questions were designed for each category in the form of three questionnaires. The questionnaires were sent to selected experts from different specialties. Experts responded to the questions in the first round. Based on the feedback, questions were modified and sent back to the experts in the second round. This procedure was repeated up to the third round.ResultsIn the first round, five items from informational needs, one item from supportive needs, and seven items from sources of obtaining information were identified as unimportant and omitted. Moreover, two extra items were proposed by the experts, which were added to the informational needs category. In the second round, seven, three, and seven items from informational needs, supportive needs, and sources of obtaining information were omitted due to the items being unimportant. In the third round, all the included items gained scores equal to or greater than the average and were identified as important. Kendall coordination coefficient W was calculated to be 0.344 for information needs, 0.330 for supportive needs, and 0.325 for sources of obtaining information, indicating a fair level of agreement between experts.ConclusionsOut of 128 items in the first round, the omission of 30 items and the addition of two items generated a 100-item questionnaire for three sections of informational needs, supportive needs, and sources of obtaining information with a high level of convergence between experts' viewpoints.
Case report: Filarial infection of a parti-coloured bat: Litomosa sp. adult worms in abdominal cavity and microfilariae in bat semen
Authors: Pikula Jiri , Piacek Vladimir , Bandouchova Hana , Bartlova Marie , Bednarikova Sarka , Burianova Romana , Danek Ondrej , Jedlicka Petr , Masova Sarka , Nemcova Monika , Seidlova Veronika , Zukalova Katerina , Zukal Jan 
Published: September 2023

BackgroundFilarial infections have been understudied in bats. Likewise, little is known about pathogens associated with the reproductive system in chiropterans. While semen quality is critical for reproductive success, semen-borne pathogens may contribute to reproductive failure.MethodsFor the first time we performed electroejaculation and used computer-assisted semen analysis to provide baseline data on semen quality in a parti-coloured bat (Vespertilio murinus).ResultsThe semen quality values measured in the V. murinus male appeared high (semen concentration = 305.4 × 106/mL; progressive and motile sperm = 46.58 and 60.27%, respectively). As an incidental finding, however, microfilariae were observed in the bat semen examined. At necropsy, eight adult filarial worms, later genetically identified as Litomosa sp., were found in the peritoneal cavity, close to the stomach, of the same particoloured bat male dying as a result of dysmicrobia and haemorrhagic gastroenteritis in a wildlife rescue centre. Histopathology revealed microfilariae in the testicular connective tissue and the epidydimal connective and fat tissues. A PCR assay targeting cytochrome c oxidase subunit 1 confirmed that adult worms from the peritoneal cavity and testicular microfilariae were of the same filarial species. Mildly engorged argasid mite larvae attached to the bat skin proved negative for filarial DNA and the adult filarial worms proved negative for endosymbiont Wolbachia.ConclusionWhile the standard filarial life cycle pattern involves a vertebrate definitive host and an invertebrate vector, represented by a blood-sucking ectoparasite, our finding suggests that microfilariae of this nematode species may also be semen-borne, with transmission intensity promoted by the polygynous mating system of vespertilionid bats in which an infected male mates with many females during the autumn swarming. Presence of microfilariae may be expected to decrease semen quality and transmission via this route may challenge the success of reproductive events in females after mating. Further investigation will be necessary to better understand the bat-parasite interaction and the life cycle of this filarial worm.
Analisis Kelayakan Usaha Kerupuk di Desa Dongkala Kecamatan Pasarwajo Kabupaten Buton (Studi Kasus Pada Aliva Kerupuk)
Authors: Purnamasari Wa Ode Dian , Ridwan Ridwan , Azizu Azelia Monica 
Published: September 2023

Tujuan dari Penelitian ini adalah (1) untuk mengetahui berapa besar pendapatan pada usaha industri Aliva Kerupuk di Desa Dongkala Kecamatan Pasarwajo Kabupaten Buton dan (2) untuk mengetahui kelayakan usaha industri Aliva Kerupuk di Desa Dongkala Kecamatan Pasarwajo Kabupaten Buton. Penelitian ini merupakan studi kasus yang mengambil obyek penelitian pada industri pengolahan kerupuk. Penentuan sampel dilakukan secara sensus dengan mengambil sampel pada Industri Aliva Kerupuk. Variabel yang diamati dalam penelitian ini yaitu biaya produksi yang terdiri dari biaya tetap dan biaya variabel, penerimaan dan pendapatan, sedangkan kelayakan usaha yang digunakan metode R/C ratio. Kesimpulan penelitian ini adalah 1) Pendapatan yang diperoleh industri Aliva Kerupuk Desa Dongkala Kecamatan Pasarwajo Kabupaten Buton adalah sebesar Rp. 6.934.000/bulan. 2) R/C Rasio yang diperoleh industri Aliva Kerupuk Desa Dongkala Kecamatan Pasarwajo Kabupaten Buton sebesar 1.96 dimana nilai tersebut lebih besar dari 1 (R/C > 1) ini berarti industri Aliva kerupuk menguntungkan atau layak untuk dikembangkan.
Efisiensi Usaha dan Faktor-Faktor Yang Mempengaruhi Produksi Pembenihan Ikan Patin
Authors: Oktaviana Anggun , Zulkarnain Zulkarnain , Syahputra Fikri , Kaizan Kaizan 
Published: September 2023

Catfish is a freshwater fish in Indonesia which is distributed mostly in Sumatra and Kalimantan. The research was conducted in Metro City with 30 samples used. Sampling technique with census method. The analysis tools are multiple linear regression analysis with the Cobb-Douglas production function, technical efficiency analysis with the Data Envelopment Analisys (DEA) approach, price/allocation efficiency analysis and economic efficiency analysis. The results showed that 1) capital production factors (X2), number of brood stock (X3), and drugs (X9) had a significant effect on the production of catfish hatcheries. 2) technical efficiency value of 0.940. 3) price/allocation efficiency value of 194,098. 4) economic efficiency value of 182,452.

Keywords: Economic efficiency, price/allocation efficiency, technical efficiency, catfish
Business Analysis Of Home Industry Of Opak Crackers
Authors: Reflis Reflis , Sumartono Eko , Yuliarti Ellys , Rasid Ilham Abdul 
Published: September 2023

Indonesia is an archipelagic country that has fertile soil and the soil is suitable for planting various kinds of food crops, one of which is cassava.Cassava (Manihot esculenta) has several advantages including being able to grow on dry and infertile land, relatively high disease resistance. Fresh cassava is an agricultural commodity with low economic value. In order to increase the economic value of cassava, an effort is needed to process cassava into processed products, namely opaque crackers. The purpose of this study is to determine income, the comparison between revenue and production costs is basedR/C ratio, a comparison between revenue and production costs based onB/C ratio on home industry Opaque crackers in Magelang Village. This research was conducted in Magelang Village, Kerkap District, North Bengkulu. This location was deliberately set with the consideration that Magelang Village is one of the opaque cracker producing centers. This study found that: 1). Total production sold by business actorshome industry opaque crackers in one production is 750 pieces with a selling price of Rp. 500 per chip, getting an average revenue in one production of Rp.375,000., with the average cost of producing one production of Rp. 130,159. So that you get income in one production of IDR 244,841. 2). Mark R/C system obtained is equal to 2.58 which means that according to the criteria of the R/C tester> 1, it can be concluded that the efforthome industry shrimp crisp Opaque in Magelang Village, Kerkap District, North Bengkulu Regency is profitable and feasible to cultivate. 3). MarkB/C ratio obtained by 1.58, whereB/C ratio in the business of making opaque crackers > 1, which is the interpretation that the efforthome industry Opak crackers in Magelang Village, Kerkap District, North Bengkulu Regency are financially feasible (earn profits) in running a business home industry opaque crackers.
Resiko Pendapatan Usaha Peternakan Kambing Rakyat Di Kabupaten Lampung Selatan
Authors: Syahputra Fikri , Zulkarnain Zulkarnain , Mardliyah Ainul , Supriyadi Supriyadi 
Published: September 2023

ABSTRACT
The aims of this study were: (1) to analyze income, (2) to analyze income risk, and (3) to analyze the factors that affect the income of people's goat farming businesses. The research was conducted in South Lampung Regency. The sample used was group members totaling 38 people. The method applied is quantitative analysis and multiple linear regression. Based on the results of the analysis, the total income of the goat farming business is Rp. 2.697.132 (R/C = 1,92) followed by cash income of Rp. 4.737.637 (R/C = 6,24). Goat farm business income risk of 0,57. The independent variables that affect the income of a goat farm business are the number of livestock sales and the length of experience in raising livestock.
Keywords: income, income risk, goat farming

ABSTRAK
Tujuan dari penelitian ini yaitu : (1) menganalisis pendapatan, (2) menganalisis resiko pendapatan, dan (3) menganalisis faktor-faktor yang mempengaruhi pendapatan usaha peternakan kambing rakyat. Penelitian dilaksanakan di Kabupaten Lampung Selatan. Sampel yang digunakan adalah anggota kelompok berjumlah 38 orang. Metode yang diterapkan adalah analisis kuantitatif dan regresi linier berganda. Berdasarkan hasil analisis diperoleh pendapatan total usaha peternakan kambing sebesar Rp. 2.697.132 (R/C = 1,92) diikuti dengan pendapatan tunai sebesar Rp. 4.737.637 (R/C = 6,24). Resiko pendapatan usaha peternakan kambing sebesar 0,57. Variabel independen yang berpengaruh terhadap pendapatan usaha peternakan kambing adalah jumlah penjualan ternak dan lama pengalaman beternak.
Kata Kunci: pendapatan, resiko pendapatan, usahaternak kambing
HUBUNGAN TERPAAN MEDIA DENGAN TINGKAT PENGETAHUAN TENTANG COVID-19
Authors: Susanto Agus , Barlian Ahmad Aniq , Latifah Ulfatul , Suwito Kristy Natalia 
Published: September 2023

Kehidupan manusia saat ini tidak dapat dilepaskan dari media, bahkan media sudah menjadi bagian dari peradaban manusia. Informasi dari berbagai saluran telah menembus berbagai batas-batas geografis manusia. Media, baik media konvensional maupun online secara masif telah menjelma menjadi sumber informasi bagi manusia. Di tengah situasi pandemi COVID-19 ini peran media menjadi sangat penting. Media berkompetisi untuk menginformasikan perkembangan COVID-19. Gempuran informasi media secara sadar atau tidak berperan dalam meningkatkan pengetahuan masyarakat tentang COVID-19. Penelitian ini secara khusus bertujuan untuk menganalisis hubungan antara terpaan media dengan tingkat pengetahuan tentang COVID-19. Penelitian ini dibedah dengan menggunakan pendekatan cross-sectional. Pengumpulan data penelitian menggunakan instrumen kuesioner yang disebarkan kepada 313 responden. Penyebaran kuesinoner dilakukan secara daring dengan bantuan layanan perkacapan online (WhatApp). Data yang terkumpul dianalisis secara univariat dan bivariat dengan menggunakan bantuan SPSS 22. Analisis hasil penelitian secara deskriptif menunjukkan bahwa mayoritas responden mengakses informasi tentang COVID-19 kurang dari 1 jam setiap hari (77,3%) dan media yang digunakan untuk mengakses informasi tentang COVID-19 paling banyak adalah media online (63,9%). Berdasarkan analisis bivariat didapatkan bahwa adanya hubungan yang signifikan antara lama waktu mendapatkan terpaan media dengan pengetahuan (p=0,014) dan tidak ada hubungan yang signifikan antara sumber informasi dengan pengetahuan (p=3,81). Peneliti menyarankan kepada para stake holder supaya secara aktif memberikan penyuluhan kesehatan untuk meningkatkan pengetahuan masyarakat tentang COVID-19.
The Influence of PT Bobotoh Indonesia Gemilang's Internal Communication on Employee Attitudes in Supporting Persib Bandung
Authors: Daningtyas Widiarizki Ajeng 
Published: September 2023

PT Bobotoh Indonesia Gemilang is one of the companies that has a clear collective identity, namely Bobotoh. The key to the formation of organizational identity is the effectiveness of internal communication within the organization. In the KBBI, bobotoh means football supporter. However, because in Sundaland itself, Persib is one of the big teams, so the meaning of bobotoh itself is more focused on Persib supporters. Engaged in trade and media, PT. BIG has a media called Bobotoh.ID. Then in the trade sector, to be precise in the distribution of goods, a subsidiary of PT BIG named Bobotoh Kopi Gadjah. The two subsidiaries use the identity of bobotoh. The purpose of this research is to find out how much influence the internal communication of PT BIG has on the attitude of employees in supporting Persib Bandung. The method used in this study is an explanatory survey method. With a population of employees of PT BIG amounting to 21 people and the same number of samples because it uses the saturated sample method. The results obtained, the value of R (correlation) between variable X and variable Y is 0.601 which means that the relationship between the Internal Communication variable (X) and Attitude (Y) is quite strong. Then, the result of T count is 3.274>T Table 2.07961 and a significance value of 0.004 <0.05, so Ho is rejected and Hi is accepted. This means that the internal communication of PT. BIG has an effect on the attitude of employees in supporting Persib.
Pengaruh Komunikasi Internal dan Komitmen Organisasi terhadap Loyalitas Kinerja Karyawan (Studi pada Bidang Manufatur PT Rudy Soetadi)
Authors: Audi Raisha Vircani 
Published: September 2023

Komunikasi internal dan komitmen organisasi dinilai berpengaruh pada loyalitas karyawan dalam perusahaan, salah satunya adalah PT. Rudy Soetady yang bergerak di bidang manufactur dan menghasilkan produksi berupa kosmetik dan healthy care. Penelitian ini dilakukan untuk mengetahui pengaruh komunikasi internal (X1) dan komitmen organisasi (X2) terhadap loyalitas kinerja karyawan (Y) PT Rudy Soetadi. Hipotesis penelitian ini adalah: tidak ada pengaruh komunikasi internal (X1) terhadap loyalitas kinerja karyawan (Y), tidak ada pengaruh komitmen organisasi (X2) terhadap loyalitas kinerja karyawan (Y), dan tidak ada pengaruh komunikasi internal dan komitmen organisasi terhadap loyalitas kinerja karyawan PT Rudy Soetadi. Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif dengan melakukan survei pada karyawan PT Rudi Soetady. Data dianalisis dengan melakukan uji validitas, uji reliabilitas, uji normalitas, uji linieritas, uji homogenitas, analisi regesi linier sederhana, analisi koefisien determinasi dan analisi korelasi. Hasil penelitian ini adalah komunikasi internal memiliki pengaruh terhadap loyalitas kinerja karyawan PT. Rudi Soetady yang dibuktikan oleh nilai t hitung X1 sebesar 2,340 > 1.984 dan nilai Sig. 0,011 < 0,05. Komitmen organisasi memiliki pengaruh terhadap terhadap loyalitas kinerja karyawan PT. Rudi Soetady yang dibuktikan oleh nilai t hitung X2 sebesar 14,997 > 1,984 dan Sig. 0,000 < 0,05. Komunikasi intenal (X1) dan komitmen organisasi (X2) memiliki pengaruh terhadap loyalitas karyawan yang dibuktikan oleh nilai 258,276 > 3,04 dan nilai Sig. 0,011 < 0,05 dan uji koefisien nilai R square sebesar 0,670 (67,0%). Variabel komunikasi internal (X1) dan komitmen organisasi (X2) terhadap loyalitas kinerja karyawan(Y) mengarah pada hubungan yang positif atau saling berpengaruh.
Kajian Etnokuliner Tradisional Suku Melayu di Kabupaten Mempawah dan Analisis Potensi Ekonominya
Authors: Syamsuri Syamsuri 
Published: September 2023

Etnokuliner adalah olahan pangan tradisional oleh suatu suku atau etnis, yang sifatnya turun temurun dan menjadi indigenous knowledge di wilayah tersebut. Tujuan penelitian ini yaitu menginventarisir olahan pangan tradisional suku Melayu di Kabupaten Mempawah dan menganalisis potensi ekonominya untuk mengetahui peluang wirausaha dari olahan pangan tersebut. Implikasi penelitian ini diharapkan dapat menambah informasi pengetahuan yang sifatnya ilmiah mengenai jenis pangan tradisional yang memiliki potensi wirausaha khususnya olahan pangan tradisional Suku Melayu di Kabupaten Mempawah. Metode penelitian untuk menginventarisir jenis olahan pangan tradisional yaitu menggunakan teknik Participatory Rural Appraisal (PRA), melalui observasi dan wawancara terhadap narasumber. Responden penelitian yaitu masyarakat Melayu di Kabupaten Mempawah, sedangkan responden kunci yang digunakan yaitu ketua adat dan masyarakat yang ahli mengolah masakan tradisional Melayu. Data empiris yang diperoleh selanjutnya dicatat dan disajikan dalam bentuk tabel, kemudian dianalisis secara deksriptif, sedangkan potensi ekonomi untuk menentukan peluang wirausahanya dianalisis menggunakan rumus penerimaan dan pendapatan. Hasil penelitian menunjukkan bahwa jenis olahan pangan tradisional Suku Melayu di Kabupaten Mempawah yaitu kerupuk basah, bubur pedas, pengkang, sotong pangkong, patlau, lemang, mie sagu, bingke berendam dan tempoyak. Analisa potensi ekonomi diperoleh bahwa penerimaan total tiap jenis olahan pangan tersebut lebih besar dibandingkan biaya operasional atau biaya pembuatannya
Development of Digital Literacy on Role of the Instagram Platform in Elementary School Students
Authors: Manan Manan , Yurfiah Yurfiah , Nuraini Nuraini , Verdianto Verdianto , Kamasiah Kamasiah 
Published: September 2023

The purpose of this study is to describe the role of the Instagram platform in increasing digital literacy among grade IV students at Elementary School Country 2 Wameo. Researchers used a qualitative descriptive research method. The subjects of this study were 25 grade IV students. This study uses instruments in collecting data, namely: observation, interviews, and documentation. The data analysis techniques used include: (1) Data reduction (2) Data presentation (3) Conclusion. The results of the study show the role of the Instagram platform in increasin students digital literacy in class IV Elementary School Country 2 Wameo creating interest in students as well as teachers and students being more creative in using technology, making use of up to date learning resources, students' skills in using new media, students obtaining a variety of relevant information. more broadly, and students have experience from the internet so they can improve students' digital literacy skills by fulfilling competencies in the form of technical abilities, critical understanding, and the ability to communicate and participate.