bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and clinical characteristics of pruritus, and the factors significantly associated with high pruritic intensity in patients with psoriasis: a cross-sectional study
Authors: Junsuwan Natchaya , Likittanasombat Surachanee , Chularojanamontri Leena , Chaiyabutr Chayada , Wongpraparut Chanisada , Silpa-archa Narumol 
Published: August 2023

Background:
Despite the significant prevalence of pruritus in psoriasis, its pathogenesis remains unknown, and research on pruritus in Thai psoriasis patients is limited.

Objectives:
The objective was to investigate the prevalence and clinical characteristics of pruritus, and the factors significantly associated with high pruritic intensity in Thai psoriasis patients.

Material and methods:
In a cross-sectional study design, pruritus data were collected from the medical records of patients who attended an outpatient psoriasis clinic in Thailand between 2020 and 2021.

Results:
The overall prevalence of pruritus was 81.2% among 314 psoriasis patients. Psoriasis patients with pruritus had higher Psoriasis Area Severity Index and Dermatology Life Quality Index scores than those without pruritus. The legs, back, arms, and scalp were the most common areas for pruritus. Pruritus was relieved with topical emollients, topical corticosteroids, and oral antihistamines in 66.3, 63.1, and 52.9% of patients, respectively. Female sex, psoriasis body surface area greater than or equal to 10%, and genital psoriasis were factors that independently predicted high pruritus intensity.

Conclusion:
Psoriasis patients should be screened and treated for pruritus to improve both psoriasis treatment outcomes and patient quality of life. Further studies are needed to clarify the most effective medications for pruritus in patients with severe psoriasis.
Systemic chemotherapy combined with radiofrequency ablation for colorectal cancer with liver metastasis: a retrospective cohort study
Authors: Tran Thang , Nguyen Hoa Thi , Pham Giang Hoang , Thi Hoang Cuc , Vu Quan Duc 
Published: August 2023

Background:
This study aims to evaluate the efficacy of systemic chemotherapy combined with radiofrequency ablation in the treatment of inoperable colorectal cancer with liver metastasis.

Materials and methods:
The authors conducted a retrospective cohort analysis on 30 patients diagnosed as colorectal cancer with liver metastasis who underwent systemic chemotherapy combined with radiofrequency ablation of the liver lesions from January 2017 to August 2020 at our institution. Responses was evaluated by International Working Group on Image-guided Tumor Ablation criteria, along with progression-free survival.

Results:
The response rate after 4 cycles and 8 cycles of chemotherapy were 73.3% and 85.2%, respectively. All patients achieved responses after of radiofrequency therapy, with the rates of complete response and partial response were 63.3% and 36.7%. The median progression-free survival was 16.7 months. After radiotherapy ablation, all patients had mild to moderate hepatic pain, 10% of patients had fever and increased liver enzymes occurred in 90% of patients.

Conclusions:
Systemic chemotherapy combined with radiofrequency ablation was safe and effective in colorectal cancer with liver metastasis and warrants further large-scale studies.
Gamma glutamyl transferase as a biomarker to predict contrast-induced nephropathy among patients with acute coronary syndrome undergoing coronary interventions: a meta-analysis
Authors: Javid Mona , Mirdamadi Arian , Javid Mohammadreza , Amini-Salehi Ehsan , Vakilpour Azin , Keivanlou Mohammad-Hossein , Porteghali Parham , Hassanipour Soheil 
Published: August 2023

Background and aims:
The third most frequent reason for hospitalized acute kidney injury is contrast-induced nephropathy (CIN). Percutaneous coronary intervention (PCI) and coronary angiography (CAG) are two interventions that can result in CIN. In this study, we sought to determine how well gamma-glutamyl transferase (GGT) can predict CIN following CAG and PCI.

Method:
Two researchers searched through PubMed, Scopus, and Web of Science in November 2022 to find articles that examined GGT levels in CIN patients following PCI or CAG. To rate the quality of the studies, the Joanna Briggs Institute Critical Appraisal Checklist was employed. The Cochran test and I2 statistics were utilized to assess study heterogeneity. To calculate the number of participants required to reject the null hypothesis, power analysis was used. We evaluated the epidemiologic strength of the results using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). The authors used Comprehensive Meta-analysis Version 3 to summarize the results.

Results:
GGT was shown to be considerably greater in patients with CIN according to the meta-analysis’s findings (odds ratio: 3.21, 95% CI: 1.26–8.15, P=0.014); nevertheless, the findings were accompanied by significant heterogeneity (I2=91.93%, P<0.001). Although the relationship between CIN and GGT was power full regarding power analysis (1- β =1, number of effect sizes=4, the average number per group=336), very low quality of evidence was observed regarding GRADE criteria.

Conclusions:
These results suggest the GGT level may be a predictor of contrast-induced nephropathy in patients having cardiac catheterization; however, more research is required to prove the epidemiological validity.
Stress-induced menstrual disorders in adolescents during the Ukrainian war: cross-sectional study
Authors: Mykolayivna Nikitina I. , Adebusoye Favor T. , Awuah Wireko A. , Anatoliivna Sinkina A. , Volodymyrivna Babar T. , Fedorivna Herasymenko S. , Abdul-Rahman Toufik 
Published: August 2023

Objective:
The objective was to investigate the peculiarities of menstrual cycle changes in teenagers exposed to a devastating war for an extended period.

Methods:
A cross-sectional study of 120 Ukrainian girls aged 9–18 asked to complete a survey about their menstrual cycle status 3–6 months after the war began. Other examination methods used included anthropometry, laboratory, and instrumental studies.

Results:
The frequency of menstrual cycle disorders in the study group was 65.8% (n=79). The following menstrual cycle disorders were most frequently reported; dysmenorrhea 45.6% (n=36), excessive menstruation during puberty 27.8% (n=22), and secondary amenorrhea 26.6% (n=21). The 52.5% (n=63) of those examined had pathological menarche. The 81.7% (n=63) of respondents reported a change in eating habits in the previous few months. The 61.9% (n=39) of these children had dyshormonal disorders or met the criteria for metabolic syndrome.

Conclusion:
Adolescent females under stress warrant a quick assessment of their psychoemotional and metabolic conditions. The protection from future menstruation and reproductive illnesses depends on this tactic. By diagnosing these conditions promptly and well-managed, adolescent females may maintain good physical and emotional health.
A case report of bilateral benign Ovarian Fibrothecoma coincidental with ascites: an unconventional co-occurrence
Authors: Mohamad Raied , Al Laham Omar , Albrijawy Reham , Sallom Mostafa , Merhij Alhasan , Almousa Mohammad 
Published: August 2023

Introduction and importance:
Ovarian fibrothecoma are a mostly benign and profoundly rare type of gonadal stromal cell tumor. It makes up 3–4% of all kinds of ovarian neoplasia. They are predominantly unilateral in origin and mostly present in women during the postmenopausal phase. Our case is especially important because the tumors occurred bilaterally and were associated with ascites. This seldom happens in patients with ovarian fibrothecoma. Early identification and treatment are key components to avoid the subsequent complications of this tumor.

Case presentation:
We present the case of a 54-year-old female who presented complaining only of a slow progressive increase in the abdominal contour associated with vague abdominal pain. Our preoperative radiological imaging revealed multiple ovarian and uterine masses.

Clinical discussion:
Surgical intervention in the form of a hysterectomy with bilateral salpingo-oophorectomy was achieved. Histopathological analysis revealed bilateral benign ovarian fibrothecoma with benign uterine leiomyomas. The patient underwent an uneventful postoperative recovery.

Conclusion:
Ovarian Fibrothecoma is a rare gynecological pathology. The uniqueness of our case stems from the rarity of its bilateral occurrence and in rare occasions, their occurrence is accompanied by ascites. This kind of co-occurrence should be differentiated from other rare presentations, such as Meigs Syndrome. Therefore, documentation is necessary to circumvent misdiagnoses and to abate the resulting patient morbidity. To further highlight the value of our case, it is to the best of our knowledge, the first documented case of this pathology from our country.
Difference in presentation, outcomes, and hospital epidemiologic trend of COVID-19 among first, second, and third waves: a review of hospital records and prospective cohort study
Authors: Mahmud Reaz , Islam Md. Ashikul , Haque Md. Emdadul , Hussain Dewan A. , Islam Mohammad R. , Monayem Farhana B. , Kamal Mohammad M. , Sina Hashmi , Islam Mohammad F. , Datta Ponkaj K. , Sayeed S.K. Jakaria B. , Dhali Sabbir A. , Islam Khairul , Ratul Rifat H. , Hossain S.K. Md. Rubaed , Prince Habib N. , Chowdhury Ahmed H. , Ahmed Kazi G.U. , Miah Md. Titu , Rahman Md. Mujibur 
Published: August 2023

Background:
This study aimed to examine the differences in epidemiologic and disease aspects among patients with coronavirus disease-19 (COVID-19).

Methods:
The authors reviewed the hospital records between April 2020 and September 2021 and followed up on the patients for post-COVID complications.

Findings:
Older adult patients were predominantly affected during the third wave, and middle-aged patients were predominantly affected during the first and second waves. Men were predominantly admitted, considering the three waves, although more women were admitted in the second wave. Cough was more common in the second and third waves than in the first wave 522 (59.7%). Respiratory distress was the most common in the third wave, 251(67.1%), and least common in the first wave, 403 (46.1%). Anosmia was more common in the third wave 116 (31.2%). In the third wave, patients presenting in a critical state 23 (6.2%) and with severe disease 152 (40.8%) were more common. The hospital admission median (IQR) was longer in the first wave, 12 (8–20), than in other waves. More patients were admitted in the first wave (52%) than in the other waves, and patients received more oxygen in the third wave (75%) than in the other waves. Death occurred more commonly in the first wave (51%) than in the other waves. The positivity rate was higher in the third wave (22.8%) than in the other waves. In the third wave, the positivity rate was higher in women (24.3%) than in men. Post-COVID cough increased in the second wave, and fatigue was higher in the third wave than in the other waves. Tiredness and memory loss were greater during the second wave than in other waves.

Conclusion:
The authors found differences in the presentation, outcomes, and hospital epidemiologic trend of COVID-19 among the three waves.
A reflection of Africa’s cardiac surgery capacity to manage congenital heart defects: a perspective
Authors: Awuah Wireko A. , Adebusoye Favour T. , Wellington Jack , Ghosh Shankhaneel , Tenkorang Pearl O. , Machai Paciencia N.M. , Abdul-Rahman Toufik , Mani Shyamal , Salam Abdus , Papadakis Marios 
Published: August 2023

Congenital heart defects (CHDs) are birth abnormalities that may drastically alter the structure and functionality of the heart. For 70% of infants with congenital disorders to survive or maintain a better quality of life, surgery is necessary. Over 500 000 of the 1.5 million CHD cases reported annually, or 1% of all live births, occur in Africa, according to the WHO. A surmounted 90% of these patients are from Africa, and as a consequence, 300 000 infants die annually as a result of poor care or difficulty accessing adequate healthcare. However, the high prevalence of CHDs, precipitated by a plethora of aetiologies worldwide, is particularly pronounced in Africa due to maternal infectious diseases like syphilis and rubella amongst the pregnant populace. In low- and middle-income countries, especially in Africa, where foreign missions and organizations care for the majority of complicated cardiac surgical patients, access to secure and affordable cardiac surgical therapy is a substantial issue. Interventions for CHDs are very expensive in Africa as many of the continent’s domiciles possess low expenditures and funding, thereby cannot afford the costs indicated by associated surgical treatments. Access to management and healthcare for CHDs is further hampered by a lack of trained surgical personnel, specialized tools, infrastructure, and diagnostic facilities in Africa.
Anxiety and depression amongst youth as adverse effects of using social media : A Review
Authors: Prasad Sakshi , Ait Souabni Sara , Anugwom Gibson , Aneni Kammarauche , Anand Ayush , Urhi Alexsandra , Obi-Azuike Crystal , Gibson Taneil , Khan Asma , Oladunjoye Funso 
Published: August 2023

Background:
Social media use has become widely popularized in modern society and because of that, human interactions have drastically changed. In parallel, depression and anxiety have reached unprecedented levels among the youth, and concerns have emerged on social media use compromising mental health. The objectives of our review are to explore if there is a relation between social media and the development of those two disorders among youth, to highlight the patterns that could lead to them, and to give recommendations for future research.

Methods:
Based on the Scale for the Assessment of Narrative Review Articles (SANRA) Criteria, the authors performed a search of all-time articles published in the Medline database using terms such as social media, social media use, problematic social media use, depression, anxiety, suicidality, self-harm, fear of missing out, cyberchondria, cyberbullying, sexting, and online shopping. The initial search yielded 184 924 articles. After review, 77 articles were included for discussion.

Results:
Social media use is often associated with depression and anxiety. Different patterns are thought to predict poorer mental health outcomes like multitasking, emotional investment, appearance-based activities, passive media use, problematic social media use, cyberbullying, sexting, and disaster awareness.

Conclusion:
Specific patterns of engagement with social media appear to be associated with poor mental health outcomes in youth. It is important for physicians to address social networks exposure in well-visits and for parents to communicate about it openly. However, more in-depth research needs to be done to determine a relation of causality.
Utility of sTREM-1 biomarker and hcp Gene for Identification of Acinetobacter baumannii Colonization and Infection in Lung
Authors: Wang Xiaolei , Jiang Jiahui , Wei Chenxing , Yang Wenjie , Chen Jian , Dong Xueyan , Wan Haitong , Yu Daojun 
Published: August 2023

Abstract

Objective
Respiratory infections or colonization of Acinetobacter baumannii (Ab) are common in clinical practice but are treated differently. Early identification of Ab infection and colonization reduces the risk of antibiotic mismatch but objective laboratory indicators to distinguish between bacterial infections and colonization are lacking. To distinguish infection and colonization of Ab, we tested the role of two biomarkers, triggering receptor expressed on myeloid cells-1 (TREM-1) and Hemolysin co-regulated protein (Hcp).

Methods
A total of 96 inpatients with Ab were divided into infection and colonization groups. Blood samples were collected on day 1, 2, 3, 5, 8 and 10 and daily maximum body temperature (T) was recorded.PCR and RT-PCR were used to detect the presence and expression levels of the hcp gene in Ab clinical isolates.

Results
sTREM-1 and PCT levels on days 1-10 and neutrophil classification (N%) on days 1-3 were different (P < 0.05) in the infection group and colonization group.ROC curves showed significant differences in N% and sTREM-1 on days 2 and 3(P < 0.01).sTREM-1 had the highest AUCROC on days 1, 2 and 3 of all the markers. On day 1, the ROC curve of "WBC&N%&PCT&sTREM-1"was statistically different from individual indices (WBC count, N% and PCT; P < 0.05) and was equal to the ROC curve of sTREM-1 (P > 0.05). 35 of 96 patients were classified as infection group and 61 as colonization group with hcp gene detection rates of 71.43% (25/35) and 31.15% (19/61), respectively. No differences in hcp gene presence and transcript levels were found between two groups (P > 0.05).

Conclusion
Dynamic monitoring of sTREM-1 and PCT are valuable in identifying Ab infection and colonization. sTREM-1, can be improved by combination with multiple biomarkers in the early stage for identification of infection and colonization. The hcp gene was more likely to be present in the infection cohort.
Textbook Oncological Outcome in European Gastrodata
Authors: Sędłak Katarzyna , Rawicz-Pruszyński Karol , Mlak Radosław , Van Sandick Johanna , Gisbertz Suzanne , Pera Manuel , Dal Cero Mariagiulia , Baiocchi Gian Luca , Celotti Andrea , Morgagni Paolo , Vittimberga Giovani , Hoelscher Arnulf , Moenig Stefan , Kołodziejczyk Piotr , Richter Piotr , Gockel Ines , Piessen Guillaume , Da Costa Paulo Matos , Davies Andrew , Baker Cara , Allum William , Romario Uberto Fumagalli , De Pascale Stefano , Rosati Ricccardo , Reim Daniel , Santos Lucio Lara , D’ugo Domenico , Wijnhoven Bas , Degiuli Maurizio , De Manzoni Giovanni , Kielan Wojciech , Frejlich Ewelina , Schneider Paul , Polkowski Wojciech P. 
Published: August 2023

Objective:
To assess the rate of textbook outcome (TO) and textbook oncological outcome (TOO) in European population based on Gastrodata registry.

Background:
TO is a composite parameter assessing surgical quality and strongly correlates with improved overall survival. Following the standard of treatment for locally advanced gastric cancer (GC), TOO was proposed as a quality and optimal multimodal treatment parameter.

Methods:
TO was achieved when all the following criteria were met: no intraoperative complications, radical resection according to the surgeon, pR0 resection, retrieval of at least 15 lymph nodes, no severe postoperative complications, no reintervention, no admission to the intensive care unit, no prolonged length of stay, no postoperative mortality and no hospital readmission. TOO was defined as TO with addition of perioperative chemotherapy compliance.

Results:
From the 2558 patients, 1700 were included in the analysis. TO was achieved in 1164 (68.5%) patients. The use of neoadjuvant chemotherapy (OR=1.33, 95%CI: 1.04-1.70) and D2 or D2+ lymphadenectomy (OR=1.55, 95%CI: 1.15-2.10) had a positive impact on TO achievement. Older age (OR=0.73, 95%CI: 0.54-0.94), pT3/4 (OR=0.79, 95%CI: 0.63-0.99), ASA 3/4 (OR=0.68, 95%CI: 0.54-0.86) and total gastrectomy (OR=0.56, 95%CI: 0.45-0.70), had negative impact on TO achievement. TOO was achieved in 388 (22.8%) patients. Older age (OR=0.37, 95%CI: 0.27-0.53), pT3-pT4 (OR=0.52, 95%CI: 0.39-0.69) and ASA 3-4 (OR=0.58, 95%CI: 95%CI: 0.43-0.79) had negative impact on TOO achievement.

Conclusion:
Despite successively improved surgical outcomes, stage‐appropriate chemotherapy in adherence to the current guidelines for multimodal treatment of GC remains poor. Further implementation of oncologic quality metrics should include greater emphasis on perioperative chemotherapy and adequate lymphadenectomy.
Autophagy preferentially degrades non-fibrillar polyQ aggregates
Authors: Zhao Dorothy Y. , Bäuerlein Felix J.B. , Saha Itika , Hartl F. Ulrich , Baumeister Wolfgang , Wilfling Florian 
Published: August 2023

SummaryAggregation of proteins containing expanded polyglutamine (polyQ) repeats is the cytopathologic hallmark of a group of dominantly inherited neurodegenerative diseases, including Huntington’s disease (HD). Huntingtin (Htt), the disease protein of HD, forms amyloid-like fibrils by liquid-to-solid phase transition. Macroautophagy has been proposed to clear polyQ aggregates, but the efficiency of aggrephagy is limited. Here, we used cryo-electron tomography to visualize the interactions of autophagosomes with polyQ aggregates in cultured cellsin situ. We found that an amorphous aggregate phase exists next to the radially organized polyQ fibrils. Autophagosomes preferentially engulfed this amorphous material, mediated by interactions between the autophagy receptor p62/SQSTM1 and the non-fibrillar aggregate surface. In contrast, amyloid fibrils excluded p62 and evaded clearance, resulting in trapping of autophagic structures. These results suggest that the limited efficiency of autophagy in clearing polyQ aggregates is due to the inability of autophagosomes to interact productively with the non-deformable, fibrillar disease aggregates.
Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery
Authors: Aiken Jayne , Holzbaur Erika L. F. 
Published: August 2023

ABSTRACTNeurons rely on long-range trafficking of synaptic components to form and maintain the complex neural networks that encode the human experience. With a single neuron capable of forming thousands of distincten passantsynapses along its axon, spatially precise delivery of the necessary synaptic components is paramount. How these synapses are patterned, and how efficient delivery of synaptic components is regulated, remains largely unknown. Here, we reveal a novel role for the microtubule severing enzyme spastin in locally enhancing microtubule polymerization to influence presynaptic cargo pausing and retention along the axon. In human neurons derived from induced pluripotent stem cells (iPSCs), we identify sites stably enriched for presynaptic components, termed ‘protosynapses’, which are distributed along the axon prior to the robust assembly of mature presynapses apposed by postsynaptic contacts. These sites are capable of cycling synaptic vesicles, are enriched with spastin, and are hotspots for new microtubule growth and synaptic vesicle precursor (SVP) pausing/retention. Disruption of neuronal spastin, either by CRISPRi-mediated depletion or transient overexpression, interrupts the localized enrichment of dynamic microtubule plus ends and diminishes SVP accumulation. Using an innovative human heterologous synapse model, where microfluidically isolated human axons recognize and form presynaptic connections with neuroligin-expressing non-neuronal cells, we reveal that neurons deficient for spastin do not achieve the same level of presynaptic component accumulation as control neurons. We propose a model where spastin acts locally as an amplifier of microtubule polymerization to pattern specific regions of the axon for synaptogenesis and guide synaptic cargo delivery.