bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of magnesium, phosphate, or zinc supplementation in intensive care unit patients—A systematic review and meta‐analysis
Authors: Vesterlund Gitte K. , Jensen Thomas S. , Ellekjaer Karen L. , Møller Morten H. , Thomsen Thordis , Perner Anders 
Published: December 2022

AbstractBackgroundLow‐serum levels of magnesium, phosphate, and zinc are observed in many intensive care unit (ICU) patients, but clinical equipoise exists regarding supplementation strategies. We aimed to assess the desirable and undesirable effects of supplementation with magnesium, phosphate, or zinc in adult ICU patients.MethodsWe conducted a systematic review with meta‐analysis of randomised clinical trials assessing the effects of supplementation with magnesium, phosphate, or zinc in adult ICU patients. Primary outcomes were mortality and duration of mechanical ventilation. We registered the protocol, followed the Preferred Reporting Items for Systematic Review and Meta‐Analysis statement, used the Cochrane risk of bias 2 tool, and the grading of recommendations, assessment, development and evaluation (GRADE) approach for assessing the certainty of the evidence.ResultsWe identified no low risk of bias trials. For magnesium supplementation, we included three trials (n = 235); the relative risk (RR) for mortality was 0.54, 95% confidence interval (CI) 0.30–0.96 compared to no supplementation (very low certainty of evidence). For zinc supplementation, two trials were included (n = 168); the RR for mortality was 0.73, 95% CI 0.41–1.28 compared to control. No trials assessed the effects of phosphate supplementation on mortality. For outcomes other than mortality, only zero or one trial was available.ConclusionsIn adult ICU patients, the certainty of evidence for the effects of supplementation with magnesium, phosphate, or zinc was very low. High‐quality trials are needed to assess the value of supplementation strategies in these patients.
Reducing unplanned general surgical readmissions: a review of the Australian and New Zealand National Surgical Quality Improvement Program Database
Authors: Pham Helen , Chen George , Hitos Kerry , Nahm Christopher B. , Sinclair Jane‐Louise , Johnston Emma , Hollands Michael , Lam Vincent , Pang Tony , Richardson Arthur 
Published: December 2022

AbstractBackgroundUnplanned surgical readmissions are an important indicator of quality care and are a key focus of improvement programs. The aims of this study were to evaluate the factors that lead to unplanned hospital readmissions in patients undergoing general surgical procedures and to identify preventable readmissions.MethodsA retrospective review of the American College of Surgeons National Surgical Quality Improvement Program database from 2016 to 2020 at a tertiary hospital was conducted to identify patients undergoing a general surgical procedure. Various perioperative parameters were studied to identify risk factors and reasons for unplanned readmission. Preventable readmissions were identified.ResultsA total of 3069 patients underwent a general surgical procedure. Of these, the overall unplanned readmission rate was 8.8% (n = 247). The most common reason for readmission was associated with surgical site infections (n = 112, 44.3%) followed by pain (n = 50, 20.2%), with over 45% deemed as preventable readmissions. Factors associated with increased risk of readmission included older age, longer index length of stay, prolonged operative time, elective procedures, higher ASA score and contaminated procedures.ConclusionUnplanned readmissions are more likely to occur in patients who develop postoperative complications. Understanding factors associated with readmissions may facilitate targeted quality improvement projects that reduce hospital readmission after surgery.
All work intensity is not created equal: Effort motives, job satisfaction and quit intentions at a grocery chain
Authors: Avgoustaki Argyro , Frankort Hans T. W. 
Published: December 2022

AbstractPrior research has shown that the well‐being of employees engaged in intensive work can vary with the discretion their jobs afford regarding how and when to carry out the work. This article explores a different avenue. It argues that well‐being also varies with employees’ individual motives for working intensively. The article introduces self‐determination theory to the domain of work intensity and focuses on two hypotheses. The first is whether intensive work driven by explicit or implicit incentives is more positively associated with an employee's job satisfaction than intensive work driven by job demands. The second is whether intensive work driven by intrinsic motives is more positively associated with job satisfaction than that driven by explicit or implicit incentives. In both these cases, the article also examines whether equivalent effects exist on (reduced) quit intentions. Original data from a major Greek grocery chain provide corroborative evidence that is robust to a rich set of covariates, including increasingly demanding adjustments for job discretion. The findings contribute to a more complete understanding of why differences in well‐being exist among employees performing intensive work, with implications for workers and employers.
Circular RNA circ0104103 inhibits colorectal cancer progression through interactions with HuR and miR‐373‐5p
Authors: Tan Pei , Sun Huiling , Xu Mu , Liu Xiangxiang , Qin Jian , Nie Junjie , Qin Xiaodan , Wang Shukui , Pan Yuqin 
Published: December 2022

AbstractEmerging evidence has suggested that circular RNAs (circRNAs) have vital functions during the initiation and progression of various diseases. However, circRNA potential mechanisms in colorectal cancer (CRC) are largely unknown. Here, we sought to investigate the role and underlying regulatory mechanism of circ0104103 in CRC. circ0104103 was validated by quantitative RT‐PCR (qRT‐PCR) and Sanger sequencing. Gain‐ and loss‐of‐function assays in cell lines and mouse xenograft models were utilized to investigate the effects of circ0104103 in CRC. RNA pull‐down assays, RNA immunoprecipitation assays, bioinformatics analyses, RNA FISH, and luciferase reporter assays were used to elucidate the potential mechanism of circ0104103 in CRC. We identified circ0104103, which is strongly downregulated in CRC tissues and cell lines. Functional studies revealed that circ0104103 inhibited CRC cell growth, migration, and invasion both in vitro and in vivo. Mechanistically, circ0104103 binds to HuR, a functional RNA‐binding protein commonly expressed in CRC. HuR binds to the 3′UTR of LACTB mRNA to facilitate stabilization and increase its expression. Moreover, circ0104103 was verified as a competing endogenous RNA (ceRNA) via negative regulation of miR‐373‐5p to increase LACTB expression, resulting in inhibiting the occurrence and progression of CRC. Taken together, our study revealed that circ0104103 acts as a tumor suppressor and may be a novel biomarker and therapeutic target in CRC.
Antidepression of Xingpijieyu formula targets gut microbiota derived from depressive disorder
Authors: Li Yannan , Yang Lixuan , Li Junnan , Gao Wei , Zhao Zhonghui , Dong Kaiqiang , Duan Wenzhe , Dai Baoan , Guo Rongjuan 
Published: December 2022

AbstractObjectiveThis investigation aims to determine the antidepressant role of Xingpijieyu formula (XPJYF) mediated via gut microbiota (GM)–brain axis.MethodsWe collected fecal microbiota from patients with depressive disorder (DD) and cultured microbiota in vitro. Some of microbiota were transplanted into germ‐free rats with the intragastric administration of XPJYF grain at the dose of 1.533 g/kg/day. The behaviors were studied by forced swimming test, open field test, sucrose preference test, and body weight. Products of hypothalamus–pituitary–adrenocortical (HPA) axis, neurotransmitter, and serum cytokines were investigated by enzyme linked immunosorbent assay. Glial fibrillary acidic protein (GFAP), a biomarker of astrocyte, was quantified using immunofluorescence. Microbiota culturing in vitro after XPJYF treatment was analyze by 16 s RNA sequencing technology. We used lipopolysaccharide (LPS) to mimic activated rat primary astrocyte in vitro. Brain‐derived neurotrophic factor (BDNF), cytokines, and oxidative stress factors were determined by western blotting, and glycometabolism in astrocyte was investigated by 2‐deoxy‐D‐glucose (2‐DG) uptake, adenosine triphosphate (ATP), and glucose‐1‐phosphate (G1P) kits.ResultsMicrobiota composition during 8 mg/ml of XPJYF (H12‐8) for 12 h showed the more consistency. Lactococcus is enriched in DD‐derived microbiota composition, and Biffdobacterium and Lactobacillus in H12‐8 group. GLUCOSE1PMETAB‐PWY and PWY‐7328 of which biofunctions were dominantly encoded by Biffdobacterium were the top two of altered pathways. XPJYF improved behaviors and repressed astrocyte activation in depression rats. XPJYF elevated 2‐DG uptake, ATP, glucose‐1‐phosphate, and brain‐derived neurotrophic factor (BDNF), and inhibited cytokines and oxidative stress in LPS‐induced astrocyte.ConclusionXPJYF treatment targets inflammation, activation, and glycometabolim in astrocyte via gut microbiota modulation, thereby improve animal behaviors, HPA axis dysfunction, and neurotransmitter synthesis in depression rats.
Oxymatrine ameliorates white matter injury by modulating gut microbiota after intracerebral hemorrhage in mice
Authors: Li Jing , Liang Jianhao , Zeng Meiqin , Sun Kaijian , Luo Yunhao , Zheng Huaping , Li Feng , Yuan Wen , Zhou Hongwei , Liu Junshan , Sun Haitao 
Published: December 2022

AbstractIntroductionWhite matter injury (WMI) significantly affects neurobehavioral recovery in intracerebral hemorrhage (ICH) patients. Gut dysbiosis plays an important role in the pathogenesis of neurological disorders. Oxymatrine (OMT) has therapeutic effects on inflammation‐mediated diseases. Whether OMT exerts therapeutic effects on WMI after ICH and the role of gut microbiota involved in this process is largely unknown.MethodsNeurological deficits, WMI, gut microbial composition, intestinal barrier function, and systemic inflammation were investigated after ICH. Fecal microbiota transplantation (FMT) was performed to elucidate the role of gut microbiota in the pathogenesis of ICH.ResultsOMT promoted long‐term neurological function recovery and ameliorated WMI in the peri‐hematoma region and distal corticospinal tract (CST) region after ICH. ICH induced significant and persistent gut dysbiosis, which was obviously regulated by OMT. In addition, OMT alleviated intestinal barrier dysfunction and systemic inflammation. Correlation analysis revealed that gut microbiota alteration was significantly correlated with inflammation, intestinal barrier permeability, and neurological deficits after ICH. Moreover, OMT‐induced gut microbiota alteration could confer protection against neurological deficits and intestinal barrier disruption.ConclusionsOur study demonstrates that OMT ameliorates ICH‐induced WMI and neurological deficits by modulating gut microbiota.
Minimally invasive para‐aortic lymph node dissection in left‐sided colonic and rectal cancer: experience based on a high‐volume centre
Authors: Sun Yanwu , Deng Yu , Lin Yu , Zhong Jingming , Lin Huiming , Weizhong Jiang , Huang Ying , Chi Pan 
Published: December 2022

AbstractAimThere is no established consensus on the optimal surgical approach to para‐aortic lymph node (PALN) dissection in patients with colorectal cancer. This study aimed to demonstrate the technical and oncological safety of minimally invasive PALN dissection for left‐sided colonic and rectal cancer patients with clinically suspected infrarenal PALN metastasis.MethodOne hundered and one patients who underwent primary tumour resection and minimally invasive (laparoscopic n = 92, robotic n = 9) PALN dissection for left‐sided colonic and rectal cancer were included. Logistic regression analysis was used to identify risk factors for PALN metastasis. Survival outcomes were evaluated using the Kaplan–Meier (log‐rank) method.ResultsPara‐aortic lymph node metastasis was pathologically confirmed in 23 patients (22.8%). Postoperative complications occurred in 22 patients (21.8%). Pathological N2 stage (OR = 9.337, p = 0.003) and inferior mesenteric artery LN metastasis (OR = 7.499, p = 0.009) were independently associated with PALN metastasis. The median follow‐up time was 32 months (range 3–92 months). In all patients, the 5‐year overall survival (OS) and progression‐free survival (PFS) rates were 76.1% and 69.5%, respectively. The 5‐year OS and PFS rates in patients with PALN metastasis were 49.8% and 47.5%, respectively. Patients with PALN metastasis had lower 5‐year OS (p = 0.023) and PFS rates (p = 0.035) than those without PALN metastasis.ConclusionMinimally invasive PALN dissection had acceptable postoperative complications and may be oncologically beneficial in selected patients with clinically suspicious PALN metastasis.
Follow‐up to low‐dose fenfluramine for Sunflower syndrome: A non‐randomized controlled trial
Authors: Patel Sandip , Geenen Kennedy R. , Dowless Dana , Bruno Patricia L. , Thiele Elizabeth A. 
Published: December 2022

AbstractAimThis study reports on the long‐term results for an initial cohort of patients with Sunflower syndrome who enrolled in an open‐label study of low‐dose fenfluramine as well as the short‐term results of a second cohort.MethodWe conducted a single‐center, open‐label study at the Massachusetts General Hospital. We analyzed the effect of fenfluramine on handwaving seizure frequency at monthly intervals during a 4‐month core study period for the second patient cohort, and we evaluated the long‐term (>2 years) effect of fenfluramine for the initial patient cohort.ResultsEight of the 10 patients from the second cohort provided analyzable seizure data. These patients experienced a 33% median reduction in seizure frequency during the core study, as compared to the previously reported 79% for the initial cohort (n = 9). Of the seven patients from the first cohort who remain on fenfluramine in the extension study, five continue to experience benefit. Fenfluramine was overall well tolerated with minimal side effects, reduced appetite and fatigue being the primary adverse events, and no evidence of cardiac valvulopathy or pulmonary hypertension.InterpretationThis study suggests fenfluramine can be an effective, durable, and well‐tolerated antiseizure medication option for patients with Sunflower syndrome.
Long‐term outcomes for females with early‐onset dystrophinopathy
Authors: Houwen‐van Opstal Saskia L. S. , Tak Ramon O. , Pelsma Maaike , van den Heuvel Frederik M. A. , van Duyvenvoorde Hermine A. , Cup Edith H. C. , Sie Lilian T. L. , Vles Johan S. H. , de Groot Imelda J. M. , Voermans Nicol C. , Willemsen Michel A. A. P. 
Published: December 2022

AbstractAimTo study long‐term disease course for females with early‐onset dystrophinopathy, including common (female) symptoms, challenges in social participation, the need for care, and current healthcare management to support guideline development.MethodTwelve females with early‐onset dystrophinopathy were followed for a median period of more than 17 years (range 1–36).ResultsOne patient died owing to end‐stage cardiac failure. Cardiac abnormalities were observed in three of the remaining 11 participants. Respiratory function was reduced in seven of 10 participants. Fatigue, myalgia, lower back pain, and arthralgia were reported in more than six of the participants. Functional status varied from exercise intolerance to wheelchair dependency. Most or all of the 10 participants reported restrictions in participation in work (n = 10), household duties (n = 10), sports (n = 9), and education (n = 8). Only a few participants received followed‐up pulmonary (n = 2) or rehabilitation (n = 3) care.InterpretationFemales with early‐onset dystrophinopathy experience a wide range of impairments, comorbidities, limitations in activities, and restrictions in social participation. The whole spectrum should be acknowledged in the healthcare setting. Neuromuscular and cardiac follow‐up are indispensable. Additional respiratory assessment and rehabilitation care are expected to improve health status and support daily activities and participation.What this paper adds

No standard diagnostic procedures seem to exist for female patients suspected for dystrophinopathy.
Female participants with early‐onset dystrophinopathy experienced a broad scope of burdening symptoms, such as fatigue, myalgia, lower back pain, and arthralgia.
None of participants worked full time, all felt restricted in paid work, and most felt restricted in education.
Most participants showed decreased lung function, while only one was symptomatic.
Availability of rehabilitation care may improve support for daily activities and participation for females with early‐onset dystrophinopathy.
Languages of origin and education in Europe: A systematic review
Authors: Alcántara Astrid Codana , Sánchez‐Martí Angelina , Rovira Jordi Pàmies 
Published: December 2022

AbstractEuropean education policies have tended to cultivate linguistic hegemony and preserve cultural uniformity, which has made it difficult for schools to support different cultural backgrounds. This has contributed to the promotion of artificial monolingual interactions that reinforce linguistic decapitalisation processes. The aim of the review on which this article reports was to investigate the treatment and education of languages of origin in Europe. We present findings from a systematic review of scientific articles published during the period 2010–2020. The main findings indicate that language and nationality are equated in European discourses and that public policies are promoted accordingly. These articulations draw on models that alternate between assimilationism and multiculturalism. Both assimilationist and multiculturalist approaches are detrimental to the supposed objective: that of promoting multilingualism. Thus, it is urgent that a consensus be reached, and certain public policies and educational practices promoted which are respectful of linguistic diversity, since the future social cohesion of our multicultural societies depends on this.
Impaired adaptive immune response in COVID‐19 convalescent patients with hematological malignancies
Authors: Kalicińska Elżbieta , Szymczak Donata , Andrasiak Iga , Milanowska Aneta , Kiraga Aleksandra , Majeranowski Alan , Jabłonowska Paula , Rybka Justyna , Maciej Zaucha , Wróbel Tomasz 
Published: December 2022

AbstractObjectivesThe immune dysregulation during SARS‐CoV‐2 has the potential to worsen immune homeostasis after recovery. Patients with hematological malignancies with COVID‐19 have changes both in the innate and adaptive immune responses. Little is known about the severity of immune dysfunction following recovery from COVID‐19 in hematological patients.MethodsHere, we performed a comprehensive analysis of the lymphocyte subsets in peripheral blood mononuclear cells by FACS Canto II in 55 patients, including 42 with hematological malignancies 4–6 weeks after COVID‐19.ResultsHematological COVID‐19 convalescents had deep reduction in CD3+ T cells, including helper T cells (CD3 + CD4+), naïve helper T cells (CD3 + CD4 + CD45RA+), and memory CD4+ T cells among with extremely low levels of Treg cells and decreased expression of both TCRα/β and TCRγ/δ. Severe immune dysregulation in hematological convalescents was expressed by increased activation of T lymphocytes, both as elevated levels of activated T cells (CD3 + HLA‐DR+) and activated cytotoxic T cells (CD3 + CD8 + HLA‐DR+).ConclusionsOur findings showed a profound impairment of the adaptive immune response in hematological convalescents which might be a result of persistent activation of T cells. Convalescents with lymphoid malignancies showed more pronounced depletion of key T lymphocytes subpopulations in creating an effective adaptive response and immune memory.
Percutaneous full endoscopic foraminotomy for treatment of cervical spinal nerve compression in horses using a uniportal approach: Feasibility study
Authors: Swagemakers Jan‐Hein , Van Daele Peter , Mageed Mahmoud 
Published: December 2022

AbstractBackgroundCervical spinal nerve insult can be a sequel of osteoarthropathy in horses due to enlargement of the articular processes (AP).ObjectivesTo describe the percutaneous endoscopic cervical foraminotomy procedure in horses.Study designEx vivo experimental study and clinical case report.MethodsThe technique was performed in three equine cadavers and in two clinical cases with history of forelimb lameness located in the caudal cervical region. Briefly, the horse was positioned in lateral recumbency, with the affected AP joint uppermost. Under fluoroscopic guidance, the endoscopic instruments (Ø 6.9 mm, length 207 mm, 25° angle of vision) were positioned at the dorsal bony margin of the intervertebral foramen (IVF). The bone was freed from soft tissues and removed using diamond various burrs, hence widening the IVF. The bone drilling was continued until the medial cortical surface of the caudal AP was removed. Thereafter, the endoscope was removed and the skin portal was closed.ResultsThe average of operation time in clinical cases was 98 ± 24 min. The horses recovered smoothly from the operation. At 12‐month follow‐up, the clinical signs had resolved completely without recurrence.Main limitationSmall number of clinical cases and absence of post‐mortem examination or histopathology performed in the cadaver study to assess possible iatrogenic injuries.ConclusionCervical spinal nerve decompression via minimal invasive foraminotomy is feasible in horses. More research is required before this procedure can be recommended in clinical cases.
Differentiation of self, anxiety, triangling and distress: A test of Bowen theory
Authors: Murdock Nancy L. , Flynn Mia C. , Bresin Romana C. 
Published: December 2022

AbstractBased in Bowen theory (Kerr, 2019; Kerr & Bowen, 1988), this study examined differentiation of self as a moderator of the relationship between anxiety and current triangling among a sample of adolescents. It also explored the relationship between specific triangle subtypes and psychological symptoms. We hypothesized that higher levels of anxiety would be associated with higher levels of triangling, and that this relationship would be weaker for participants who report higher levels of differentiation of self. Additionally, we hypothesized that psychological symptoms would be significantly lower for those who indicated a balanced triangle configuration to characterize their family structure (as compared to those selecting scapegoating, cross‐generational coalition or mediator patterns). Results partially supported our hypotheses; differentiation performed as a moderator in two analyses, but not in others. Higher levels of psychological symptoms were associated with experience with mediator and cross‐generational triangling.