bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity, reliability, responsiveness and interpretability of the Recap of atopic eczema (RECAP) questionnaire
Authors: Zhang Junfen , Ragamin Aviël , Romeijn Geertruida L E , Loman Laura , Oosterhaven Jart A F , Schuttelaar Marie L A 
Published: July 2023

Abstract

Background
Limited research has been conducted on the measurement properties of the Recap of atopic eczema (RECAP) questionnaire, particularly in relation to interpretability.

Objectives
To investigate the validity, reliability, responsiveness and interpretability of the Dutch RECAP in adults with atopic dermatitis (AD).

Methods
We conducted a prospective study in a Dutch tertiary hospital, recruiting adults with AD between June 2021 and December 2022. Patients completed the RECAP questionnaire, reference instruments and anchor questions at the following three timepoints: baseline, after 1–3 days and after 4–12 weeks. Hypotheses testing was used to investigate single-score validity and change-score validity (responsiveness). To assess reliability, both standard error of measurement (SEMagreement) and intraclass correlation coefficient (ICCagreement) were reported. To assess the interpretability of single scores, bands for eczema control were proposed. To investigate the interpretability of change scores, both smallest detectable change (SDC) and minimally important change (MIC) scores were determined. To estimate the MIC scores, four different anchor-based methods were employed: the mean change method, 95% limit cut-off point, receiver operating characteristic curve and predictive modelling.

Results
In total, 200 participants were included (57.5% male sex, mean age 38.5 years). Of the a priori hypotheses, 82% (single-score validity) and 59% (responsiveness) were confirmed. Known-group analyses showed differences in the RECAP scores between patient groups based on disease severity and impairment of the quality of life. The SEMagreement was 1.17 points and the ICCagreement was 0.988. The final banding was as follows: 0–1 (completely controlled); 2–5 (mostly controlled); 6–11 (moderately controlled); 12–19 (a little controlled); 20–28 (not at all controlled). Moreover, a single cut-off point of ≥ 6 was determined to identify patients whose AD is not under control. The SDC was 3.2 points, and the MIC value from the predictive modelling was 3.9 points. Neither floor nor ceiling effects were observed.

Conclusions
The RECAP has good single-score validity, moderate responsiveness and excellent reliability. This study fills a gap in the interpretability of the RECAP. Our results indicate a threshold of ≥ 6 points to identify patients whose AD is ‘not under control’, while an improvement of ≥ 4 points represents a clinically important change. Given its endorsement by the Harmonising Outcome Measures for Eczema initiatives, the results of this study support the integration of RECAP into both routine clinical practice and research settings.
Temporal and spatial factors influencing Systena frontalis (Coleoptera: Chrysomelidae) behavior in Virginia nurseries
Authors: Lane Eleanor L , Del Pozo-Valdivia Alejandro I 
Published: July 2023

Abstract
Ornamental plant production in eastern Virginia nurseries have been greatly impacted by Systena frontalis (F.), also known as the red-headed flea beetle. With the advent of S. frontalis as a prevalent pest in the past 2 decades, baseline phenology and behavior are currently understudied within Virginia nurseries. This pest is costly to control due to insecticide expenses and loss of saleable plants. In 2021 and 2022, populations of this insect were monitored at 2 commercial nurseries in eastern Virginia in order to better understand their temporal and spatial population dynamics. Patterns that emerged indicated S. frontalis could have up to 3 generations in eastern Virginia, with peaks of adult abundance in June, late July, and late August to early September. Phenylethyl alcohol was tested as an adult attractant lure, but it was found to be ineffective under nursery conditions. Diel monitoring demonstrated these adults were most active from 1100 to 1500 h. Severity of defoliation at the leaf level increased linearly with increased density of adults, where 5 individuals defoliated up to 4% of any Hydrangea paniculata cv. ‘Limelight’ leaf in 1 wk under greenhouse conditions. Timing of scouting and insecticide sprays according to the adult activity peaks of the day and across the season may allow reduction in overall insecticide usage.
A pear S1-bZIP transcription factor PpbZIP44 modulates carbohydrate metabolism, amino acid, and flavonoid accumulation in fruits
Authors: Wang Hong , Xu Kexin , Li Xiaogang , Blanco-Ulate Bárbara , Yang Qingsong , Yao Gaifang , Wei Yiduo , Wu Jun , Sheng Baolong , Chang Youhong , Jiang Cai-Zhong , Lin Jing 
Published: July 2023

Abstract
Fruit quality is defined by attributes that give value to a commodity. Flavor, texture, nutrition, and shelf life are key quality traits that ensure market value and consumer acceptance. In pear fruit, soluble sugars, organic acids, amino acids, and total flavonoids contribute to flavor and overall quality. Transcription factors (TFs) regulate the accumulation of these metabolites during development or in response to the environment. Here, we report a novel TF, PpbZIP44, as a positive regulator of primary and secondary metabolism in pear fruit. Analysis of the transient overexpression or RNAi-transformed pear fruits and stable transgenic tomato fruits under the control of the fruit-specific E8 promoter demonstrated that PpZIP44 substantially affected the contents of soluble sugar, organic acids, amino acids, and flavonoids. In E8::PpbZIP44 tomato fruit, genes involved in carbohydrate metabolism, amino acid, and flavonoids biosynthesis were significantly induced. Furthermore, in PpbZIP44 overexpression or antisense pear fruits, the expression of genes in the related pathways was significantly impacted. PpbZIP44 directly interacted with the promoter of PpSDH9 and PpProDH1 to induce their expression, thereby depleting sorbitol and proline, decreasing citrate and malate, and enhancing fructose contents. PpbZIP44 also directly bound to the PpADT and PpF3H promoters, which led to the carbon flux toward phenylalanine metabolites and enhanced phenylalanine and flavonoid contents. These findings demonstrate that PpbZIP44 mediates multimetabolism reprogramming by regulating the gene expression related to fruit quality compounds.
Transitional justice and online social platforms: Facebook and the Rohingya genocide
Authors: Nourooz Pour Hesam 
Published: July 2023

Abstract
This article examines the complex role of social media platforms in transitional justice processes, with a particular focus on the challenges and impediments these platforms can present. Using the Rohingya genocide as a case study, we scrutinize the destructive impact that social media, especially Facebook, can have when misused for inciting hate speech and violence. Furthermore, the article delves into the governance mechanisms of social media platforms, shedding light on the failures that contributed to the genocide. In this exploration, we identify both internal and external governance mechanisms that faltered in their duty to protect human rights. The article also scrutinizes legal mechanisms available for bringing justice to genocide victims at both international and domestic levels. Ultimately, this article contributes to ongoing discussions about digital platform accountability, the intersection of human rights and online content moderation and the importance of rigorous platform governance in the context of transitional justice.
Rulemaking Speed in the US States
Authors: Boushey Graeme T , McGrath Robert J 
Published: July 2023

Abstract
This paper explores the speed of rulemaking in American state governments. Drawing on a unique data set of over 250,000 individual rules issued by states from 1993 through 2009, we introduce new measures of the speed and breadth of rulemaking in American state bureaucracies, providing a new way of evaluating the incidence of rulemaking delay within and across governments. We focus specifically on how professionalism and oversight powers of state legislative and executive branches affect rulemaking speed and find that states with more professionalized legislatures and governments with extensive legislative/executive oversight powers experience greater delays in rule adoption. These findings provide important new insights into the politics of regulatory delay and suggest disparate ways in which sub-national governments approach regulatory policymaking in a federal system.
Reduced risk of mortality among COVID-19 patients with in-hospital selective serotonin reuptake inhibitor administration
Authors: Hasse Adam , Korwek Kimberly M , Poland Russell E 
Published: July 2023

AbstractObjectivesThe anti-inflammatory properties of selective serotonin reuptake inhibitors (SSRI)s, particularly fluvoxamine, have been hypothesized to reduce clinical deterioration in patients with COVID-19 when administered early in the disease course. The objective of this analysis was to examine the effect of maintenance SSRI administration, including variation among different medications, on the outcomes of hospitalized patients with COVID-19.MethodsRetrospective analysis of disease progression and mortality risk of over 230,000 patients hospitalized with COVID-19 at facilities associated with a large healthcare system in the United States.Key findingsReceipt of SSRIs during the hospital encounter occurred in approximately 10.6% (n = 24,690) of COVID-19 patients. When matched for patient characteristics, disease severity and other treatments, receipt of any SSRI was associated with a 30% reduction in the relative risk of mortality (RR: 0.70, 95% confidence interval [CI]: 0.67–0.73; adjusted P-value &lt;0.001). Similar reductions in the relative risk of mortality were seen with nearly every individual SSRI; for sertraline-treated patients, the most commonly used SSRI in the data set, there was a 29% reduction in the relative risk of mortality (RR: 0.71, 95% CI: 0.66–0.77; adjusted P-value &lt;0.001).ConclusionsIn total, this retrospective analysis suggests that there is a significant association between SSRI antidepressants and reduced morality among patients hospitalized with COVID-19.
Spectroscopic follow-up of black hole and neutron star candidates in ellipsoidal variables from Gaia DR3
Authors: Nagarajan Pranav , El-Badry Kareem , Rodriguez Antonio C , van Roestel Jan , Roulston Benjamin 
Published: July 2023

ABSTRACT
We present multi-epoch spectroscopic follow-up of a sample of ellipsoidal variables selected from Gaia Data Release 3 (DR3) as candidates for hosting quiescent black holes (BHs) and neutron stars (NSs). Our targets were identified as BH/NS candidates because their optical light curves – when interpreted with models that attribute variability to tidal distortion of a star by a companion that contributes negligible light – suggest that the companions are compact objects. From the likely BH/NS candidates identified in recent work accompanying Gaia DR3, we select 14 of the most promising targets for follow-up. We obtained spectra for each object at 2–10 epochs, strategically observing near conjunction to best constrain the radial velocity semi-amplitude. From the measured semi-amplitudes of the radial velocity curves, we derive minimum companion masses of $M_{2,\, \rm min} \le 0.5 \, {\rm M}_{\odot }$ in all cases. Assuming random inclinations, the typical inferred companion mass is $M_2 \sim 0.15\, {\rm M}_{\odot }$. This makes it unlikely that any of these systems contain a BH or NS, and we consider alternative explanations for the observed variability. We can best reproduce the observed light curves and radial velocities with models for unequal-mass contact binaries with star-spots. Some of the objects in our sample may also be detached main-sequence binaries, or even single stars with pulsations or star-spot variability masquerading as ellipsoidal variation. We provide recommendations for future spectroscopic efforts to further characterize this sample and more generally to search for compact object companions in close binaries.
High-Altitude Andean H194R HIF2A Allele Is a Hypomorphic Allele
Authors: Jorgensen Kelsey , Song Daisheng , Weinstein Julien , Garcia Obed A , Pearson Laurel N , Inclán María , Rivera-Chira Maria , León-Velarde Fabiola , Kiyamu Melisa , Brutsaert Tom D , Bigham Abigail W , Lee Frank S 
Published: July 2023

Abstract
For over 10,000 years, Andeans have resided at high altitude where the partial pressure of oxygen challenges human survival. Recent studies have provided evidence for positive selection acting in Andeans on the HIF2A (also known as EPAS1) locus, which encodes for a central transcription factor of the hypoxia-inducible factor pathway. However, the precise mechanism by which this allele might lead to altitude-adaptive phenotypes, if any, is unknown. By analyzing whole genome sequencing data from 46 high-coverage Peruvian Andean genomes, we confirm evidence for positive selection acting on HIF2A and a unique pattern of variation surrounding the Andean-specific single nucleotide variant (SNV), rs570553380, which encodes for an H194R amino acid substitution in HIF-2α. Genotyping the Andean-associated SNV rs570553380 in a group of 299 Peruvian Andeans from Cerro de Pasco, Peru (4,338 m), reveals a positive association with increased fraction of exhaled nitric oxide, a marker of nitric oxide biosynthesis. In vitro assays show that the H194R mutation impairs binding of HIF-2α to its heterodimeric partner, aryl hydrocarbon receptor nuclear translocator. A knockin mouse model bearing the H194R mutation in the Hif2a gene displays decreased levels of hypoxia-induced pulmonary Endothelin-1 transcripts and protection against hypoxia-induced pulmonary hypertension. We conclude the Andean H194R HIF2A allele is a hypomorphic (partial loss of function) allele.
Phase-transforming mechanical metamaterials with dynamically controllable shape-locking performance
Authors: Zhong Yiding , Tang Wei , Xu Huxiu , Qin Kecheng , Yan Dong , Fan Xujun , Qu Yang , Li Zhaoyang , Jiao Zhongdong , Yang Huayong , Zou Jun 
Published: July 2023

ABSTRACT
Active mechanical metamaterials with customizable structures and deformations, active reversible deformation, dynamically controllable shape-locking performance and stretchability are highly suitable for applications in soft robotics and flexible electronics, yet it is challenging to integrate them due to their mutual conflicts. Here, we introduce a class of phase-transforming mechanical metamaterials (PMMs) that integrate the above properties. Periodically arranging basic actuating units according to the designed pattern configuration and positional relationship, PMMs can customize complex and diverse structures and deformations. Liquid–vapor phase transformation provides active reversible large deformation while a silicone matrix offers stretchability. The contained carbonyl iron powder endows PMMs with dynamically controllable shape-locking performance, thereby achieving magnetically assisted shape locking and energy storing in different working modes. We build a theoretical model and finite element simulation to guide the design process of PMMs, so as to develop a variety of PMMs with different functions suitable for different applications, such as a programmed PMM, reconfigurable antenna, soft lens, soft mechanical memory, biomimetic hand, biomimetic flytrap and self-contained soft gripper. PMMs are applicable to achieve various 2D deformations and 2D-to-3D deformations, and integrate multiple properties, including customizable structures and deformations, active reversible deformation, rapid reversible shape locking, adjustable energy storing and stretchability, which could open a new application avenue in soft robotics and flexible electronics.
Queer and Trans Qualitative Music Therapy Research
Authors: Forinash Michele , Thomas Natasha 
Published: July 2023

Abstract
This chapter addresses topics related to queer and trans qualitative research in music therapy. We share our own research lineages along with a beginning definition of queer and trans research. This is followed by a discussion of why queer and trans research is needed and our location as researchers. A connection to post-qualitative research is explored. Traditional concepts such as ontology, epistemology, and methodology are discussed from a queer and trans perspective. Specifically, ontology is examined and how it differs between people. Epistemology askes what counts as knowledge, and methodology asks if we have to summarize what we understand. Action includes understanding ourselves in a social context, and the social constructs that define power and how research can create transformation for queer and trans people.
Nearly Underground in the Near-Abroad
Authors: Svede Mark Allen , Vērdiņš Kārlis 
Published: July 2023

Abstract
This chapter examines alternative culture in Estonia, Latvia, and Lithuania during the period of their annexation by the Soviet Union from 1945 onward, focusing primarily on visual art with correlations in the literary realm. Because artists and writers in the Baltic republics first encountered Socialist Realism as a fully articulated aesthetic policy and ultimately submitted to its requirements for a shorter duration, their methods of accommodation and resistance differed from those elsewhere in the USSR. The republics’ special cultural status and peripheral location created a different subcultural, oppositional dynamic, which has caused some scholars and even participants to question whether a true underground existed. Attention is also devoted to the asynchronic development of the three respective alternative cultures, as well as formal characteristics that distinguished them from each other as well as from non-Baltic Soviet republics.
Young Conceptualists
Authors: Glanc Tomáš 
Published: July 2023

Abstract
Тhis chapter discusses the second generation of Moscow Conceptualists, which includes such groups as the Mukhomors (Fly-Agaric), Gnezdo (Nest), Chempiony mira (World Champions), Inspektsia “Meditsinskaia Germenevtika” (Inspection “Medical Hermenutics”), Srednerusskaq vozvyshennost’ (Central Russian Upland), the writer Vladimir Sorokin, as well as the Aptart movement. Not confronting the aesthetics of the older generation of Conceptualists (Kabakov, Bulatov, Komar and Melamid, Monastyrskii, Prigov, Rubinshtein), Young Conceptualists, on the one hand, radicalized their practices and languages, and on the other hand, ironically reworked them. Young Conceptualists, in several cases, make use of a playful but substantive polemic with the Conceptualist legacy, challenging, from within Conceptualist discourse, the way it has become enclosed around its own values and aesthetic principles. The chapter highlights the new role of performances and conversations as conceptualist genres, the developing of archives as an artistic practice (MANI folders, NOMA), and the creation of Conceptualist journals.
Utopian Socialism in Britain
Authors: Falchi Federica 
Published: July 2023

Abstract
In the first half of the nineteenth century, early socialism, which Marx and Engels called utopian socialism, spread in the United Kingdom. The main feature of utopian socialism was the ambition to inspire a new science of humanity and a society that would promote and solidify the principles of community and equality, including between men and women, through a series of reforms designed to affect economic, legal, and political institutions. Although Robert Owen is considered the founder of utopian socialism in the United Kingdom, this chapter explores the contribution made by women to the development of utopian socialism. Particular attention is given to Anna Doyle Wheeler and Frances Wright. Even though they started from an adherence to Owen’s principles, they enriched the meaning of utopian socialism and made it more impactful than Owen’s version, especially concerning the issues of slaves and women.
Utilitarianism
Authors: Gardner Catherine Villanueva 
Published: July 2023

Abstract
The chapter explores the utilitarian thinking of a diverse range of nineteenth-century women philosophers from Britain and America, including Harriet Taylor, Catharine Beecher, Frances Wright, Anna Doyle Wheeler, and Frances E. W. Harper. The latter three—Wright, Wheeler, and Harper—are less recognized, and the chapter offers the opportunity to aid their retrieval for the canon. The utilitarianism of these thinkers was no one thing, but it ranged from the conservative ideas of Beecher, to Wright’s radical call for race and gender justice, to Harper’s goal of racial uplift, to the ideal socialist society proposed by Wheeler, and to Taylor’s argument for women to be financially independent.
From the French Revolution to Nineteenth Century America
Authors: Bergès Sandrine 
Published: July 2023

Abstract
The works of French Revolution–era philosopher Germaine de Staël were popular in nineteenth-century America. Her conception of human perfectibility and her views about how women might contribute to it were particularly influential. This chapter traces her influence in the works of two American women: Louisa May Alcott and Anna Julia Cooper. Louisa May Alcott mentions Staël in a novel about women’s emancipation and influence on human progress, Work. Anna Julia Cooper, who cites Staël in A Voice from the South, embraces Staël’s account of human progress and her essentialism about womanhood but transforms these into a thesis on the necessity of women, Black men, and, especially, Black women’s participation in progress.
Sexual Politics and Ethics
Authors: Regard Frédéric 
Published: July 2023

Abstract
When the first Contagious Diseases Act was passed in the British Parliament in 1864, the official explanation was that the army had to be protected from syphilis. Josephine Butler launched a crusade against these acts, arguing that a double standard had presided over their conception. For her, the hidden ambition of the new legislation was to sanitize extramarital sex. Butler’s speeches and pamphlets called to arms a new class of citizens concerned about growing state control over the individual, which she denounced as the “despotism of the future.” The philosophical weapons with which she waged her war, drawing on the Bible and tapping the resources of the Nonconformist tradition, may explain why Butler was neglected in the history of feminism. But the image she fashioned for herself was quite revolutionary: a sociologist, an investigative journalist, and an activist at the same time; Butler was most certainly pioneering the feminism of the future.
Understanding and Working with Adults with NSSI
Authors: Andover Margaret , Kim Hae-Joon , Corcoran Vincent , Hiner Michelle , Rabasco Ana , DeSon Joshua 
Published: July 2023

Abstract
This chapter elaborates on the prevalence of nonsuicidal self-injury (NSSI) among adults. NSSI severity can be characterized in different ways, including increased versatility, increased frequency, need for medical attention due to the physical harm caused by NSSI, or self-reported subjective severity. Moreover, NSSI commonly co-occurs with other psychiatric disorders. According to NSSI research focused on adult samples, the functions of NSSI primarily reduce unwanted negative emotions, which is similar to other age groups. The chapter clarifies how critical it is to recognize that NSSI is not limited to the youth so prevention and intervention must be accessible to people of all ages.