bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poulain de la Barre, Francois
Authors: Reuter Martina , Parsio Tuomas 
Published: March 2023

François Poulain (or Poullain) de la Barre (b. 1648–d. 1723) was born in Paris to wealthy Catholic parents. He earned his bachelor’s degree in theology at Sorbonne in 1666, but left university to explore a secular career as a writer. He returned to theology and was ordained a Catholic priest in 1679, after which he served as a curate in Picardy, an area with a large Protestant population. Poulain underwent two major conversions during his lifetime: from the Scholasticism of Sorbonne to Cartesian philosophy in the 1660s and from Catholicism to Protestantism in the 1680s. The latter conversion made him resettle in Geneva, where he had a family and a teaching career. Poulain is best known for his three treatises on women and equality, On the Equality of the Two Sexes (1673), On the Education of Ladies (1674), and On the Excellence of Men (1675), but it is fair to say that all his writings were guided by some practical aim. He wanted to bring about equality between the sexes, but also to advocate a new Cartesian approach to philosophy, to give advice on language use, and to defend rational theology in the tense times of religious persecution and upheaval created by rivalling denominations of Christianity. Poulain’s thought was deeply influenced by Descartes’ methods of doubt and scientific reasoning, by his criticism of prejudice and Scholastic science, and by his distinction between mind and body and his mechanistic concept of body. Still, like many Cartesians, Poulain was an undogmatic follower of Descartes, and he considerably extended the realm of Cartesian philosophy by applying Descartes’ methodological insights to social and political issues such as the subjugation of women. Poulain also revised Descartes’ philosophical method by advocating a turn from solitary meditation toward joint conversations. Scholarship on Poulain has focused on him as a Cartesian philosopher and early defender of the equality of the sexes. Many studies combine these topics and examine his writings as articulations of early modern Cartesian feminism. There is also a small but vital number of scholars publishing mostly in French on Poulain’s writings about language and theology. Though writing before the times of explicit demands for women’s political rights and well before the coinage of the term feminism, Poulain deserves the title of feminist in the sense that he developed a detailed analysis of many different aspects of the subjugation of women by male power.
Ming Poetry 1368–1521: Era of Archaism
Authors: Lin Tsung-Cheng 
Published: March 2023

Ming poetry not merely outnumbers the amount of Tang and Song poetry but also represents an important transition in Chinese poetics. Yuan Xingpei 袁行霈 divides Ming poetry into two major periods. The first period (1368–1521) was the age of archaism, during which the archaist poetic movement, led by Qian qizi 前七子 (the Earlier Seven Masters), became the predominant mode of literary thought. The second period (1522–1644) was the age of new poetic trends, which saw the interweaving of archaist and xingling性灵 (native sensibility) poetics and the poetic incorporation of literary devices and subject matter from popular literature such as drama and fiction. The first period can be further divided into three stages in accordance with the archaist movement. During the first stage (1368–1420), learning from pre-Yuan poetry was highly valued. Additionally, the poetry of this stage placed a special emphasis on the moral didactics advocated by Zhu Xi’s 朱熹 (b. 1130–d. 1200) Neo-Confucianism. The second stage spans the sixty years following the relocation of the imperial capital to Beijing in 1421. The taige ti台阁体 (secretariat style) dominated the first half of this stage, while Li Dongyang 李东阳 (b. 1447–d. 1516) and the Chaling 茶陵school dominated the second half. During this stage, archaism was further promoted among official-literati circles. The third stage, the age of the Earlier Seven Masters, lasted from 1481 to 1521, during which archaism reached the summit of its development. During this time, archaism also prevailed in regional literati circles. Minzhong shizi 闽中十子 (The Ten Talents of Min), archaist poets from the Fujian area, were the most important advocates of Yan Yu’s 严羽 (fl. 1191–1241) poetics and exercised great influence over the Earlier Seven Masters’ literary movement. The first period was the pinnacle of archaist thought; however, this period was equally important for the development of xingling性灵 literary thought. Wuzhong sicaizi 吳中四才子 (The Four Talents of Wu) were major advocates of xingling poetics during this period. Xingling poetics gradually increased in popularity among the regional literati circles that would ultimately lay the foundations for the full development of xingling thought in the second period of the Ming.
The transcription factor CmERFI-2 represses CmMYB44 expression to increase sucrose levels in oriental melon fruit
Authors: Gao Ge , Yang Fan , Wang Cheng , Duan Xiaoyu , Li Meng , Ma Yue , Wang Feng , Qi Hongyan 
Published: March 2023

Abstract
Soluble sugar accumulation in fruit ripening determines fleshy fruit quality. However, the molecular mechanism for this process is not yet understood. Here, we showed a transcriptional repressor, CmMYB44 regulates sucrose accumulation and ethylene synthesis in oriental melon (Cucumis. melo var. makuwa Makino) fruit. Overexpressing CmMYB44 suppressed sucrose accumulation and ethylene production. Furthermore, CmMYB44 repressed the transcriptional activation of CmSPS1 (sucrose phosphate synthase 1) and CmACO1 (ACC oxidase 1), two key genes in sucrose and ethylene accumulation, respectively. During the later stages of fruit ripening, the repressive effect of CmMYB44 on CmSPS1 and CmACO1 could be released by overexpressing CmERFI-2 (ethylene response factor I-2) and exogenous ethylene in “HS” fruit (high sucrose accumulation fruit). CmERFI-2 acted upstream of CmMYB44 as a repressor by directly binding the CmMYB44 promoter region, indirectly stimulating the expression level of CmSPS1 and CmACO1. Taken together, we provided a molecular regulatory pathway mediated by CmMYB44, which determines the degree of sucrose and ethylene accumulation in oriental melon fruit and sheds light on transcriptional responses triggered by ethylene sensing that enable the process of fruit ripening.
Construct validity of movement-evoked pain operational definitions in older adults with chronic low back pain
Authors: Knox Patrick J , Simon Corey B , Pohlig Ryan T , Pugliese Jenifer M , Coyle Peter C , Sions Jaclyn M , Hicks Gregory E 
Published: March 2023

AbstractObjectiveMovement-evoked pain (MeP) may predispose the geriatric chronic low back pain (LBP) population to health decline. As there are differing operational definitions for MeP, the question remains as to whether these different definitions have similar associations with health outcomes in older adults with chronic LBP.DesignCross-sectional analysis of an observational study.SettingClinical research laboratory.Subjects226 older adults with chronic LBP.MethodsThis secondary analysis used baseline data from a prospective cohort study (n = 250). LBP intensity was collected before and after the repeated chair rise test, stair climbing test, and 6-minute walk test; MeP change scores (ie, sum of pretest pain subtracted from posttest pain) and aggregated posttest pain (ie, sum of posttest pain) variables were calculated. LBP-related disability and self-efficacy were measured by the Quebec Back Pain Disability Scale (QBPDS) and Low Back Activity Confidence Scale (LOBACS), respectively. Physical function was measured with the Health ABC Performance Battery. Robust regression with HC3 standard errors was used to evaluate adjusted associations between both MeP variables and disability, self-efficacy, and physical function.ResultsGreater aggregated posttest MeP was independently associated with worse disability (b = 0.593, t = 2.913, P = .004), self-efficacy (b = –0.870, t = –3.110, P = .002), and physical function (b = –0.017, t = –2.007, P = .039). MeP change scores were not associated with any outcome (all P &gt; .050).ConclusionsAggregate posttest MeP was linked to poorer health outcomes in older adults with chronic LBP, but MeP change scores were not. Future studies should consider that the construct validity of MeP paradigms partially depends on the chosen operational definition.
Implementation in action: developing implementation strategies for an evidence-based prevention program
Authors: Chippendale Tracy 
Published: March 2023

Abstract
In this commentary, I introduce existing literature on implementation mapping and the development of implementation strategies. I argue that educational materials describing essential features of a prevention program are needed regardless of the program site and therefore may be a good starting point in the implementation process. I use the development of educational materials and resources for the Stroll Safe outdoor falls prevention program as an example to illustrate the process used.
A Multidisciplinary Team Approach for Diabetic Foot Ulcer: A Case Study
Authors: Xu Beihua , Song Xia , Weng Yajuan 
Published: March 2023

ABSTRACT
A multidisciplinary team (MDT) approach is the most efficient way to treat many chronic and serious diseases. In this case report, providers sought to implement an MDT approach to treat a patient with diabetes and foot ulcers, actively involving the patient’s caregiving family members. Comprehensive evaluation, blood sugar control, and timely referral were established as the primary treatment course. Negative-pressure wound therapy was applied to completely remove necrotic tissue debris and seropurulent discharge from the foot ulcers under the consultation of the MDT team. Local wound management, protection of the periwound skin, and health education for the patient’s wound care nurse specialists were integral to the treatment outcome. After 3 months of treatment, the patient’s right foot wound bed was improved, and further skin-grafting surgery was performed to accelerate the healing process during follow-up treatments.
Single Nucleotide Polymorphisms and Adolescent Idiopathic Scoliosis
Authors: AlMekkawi Ahmad K. , Caruso James P. , El Ahmadieh Tarek Y. , Palmisciano Paolo , Aljardali Marwa W. , Derian Armen G. , Al Tamimi Mazin , Bagley Carlos A. , Aoun Salah G. 
Published: March 2023

Study Design.
Meta-analysis.

Objective.
To determine the single nucleotide polymorphisms (SNPs) that are related to adult idiopathic scoliosis.

Summary and Background Data.
Adolescent idiopathic scoliosis (AIS) is considered one of the most prevalent spinal diseases. Even though the cause of AIS is yet to be determined, family history and sex have shown conclusive associations. Multiple studies have indicated that AIS is more prevalent in families where at least one other first-degree relative is similarly affected, indicating a possible genetic etiology to AIS.

Materials and Methods.
Articles were collected from 3 different search engines and then processed in 2 stages for final article selection for quantitative analysis. Five different genetic models were represented to show the association between the different SNPs and AIS. The Hardy-Weinberg equilibrium was examined using Fisher exact test, with significance set at P <0.05. The final analysis paper’s quality was evaluated using the Newcastle Ottawa Scale. Kappa interrater agreement was calculated to evaluate the agreement between authors.

Results.
The final analysis comprised 43 publications, 19412 cases, 22005 controls, and 25 distinct genes. LBX1 rs11190870 T>C and MATN-1 SNPs were associated with an increased risk of AIS in one or all of the 5 genetic models. IGF-1, estrogen receptor alfa, and MTNR1B, SNPs were not associated with AIS in all 5 genetic models. Newcastle Ottawa Scale showed good quality for the selected articles. Cohen k = 0.741 and Kappa interrater agreement of 84% showed that the writers were in strong agreement.

Conclusions.
There seem to be associations between AIS and genetic SNP. Further larger studies should be conducted to validate the results.
Variation in Lumbar Shape and Lordosis in a Large Asymptomatic Population
Authors: Shen Yong , Sardar Zeeshan M. , Le Huec Jean-Charles , Bourret Stéphane , Hasegawa Kazuhiro , Wong Hee Kit , Liu Gabriel , Hey Hwee Weng Dennis , Riahi Hend , Kelly Michael , Lombardi Joseph M. , Lenke Lawrence G. 
Published: March 2023

Study Design.
Prospective, cross-sectional cohort study.

Objective.
To determine the relationship between lumbar shape and sagittal parameters.

Summary of Background Data.
Understanding the lumbar shape is vital for deformity surgery. Normative sagittal parameters and spine shape remain unstudied in large, multiethnic, asymptomatic cohorts.

Materials and Methods.
A prospective, cross-sectional cohort of 468 asymptomatic volunteers between 18 and 80 years was enrolled across 5 countries. Demographic data and radiographic parameters such as pelvic incidence (PI) were collected. Pearson correlation test and linear regression were used to find the relationship between lumbar lordosis (LL) and other parameters. One-way analysis of variance and Welch 2-sample t test were performed to compare lumbar shape across such categories as PI and lumbar apex followed by post hoc Bonferroni correction if needed.

Results.
PI was moderately correlated with proximal lumbar lordosis (pLL) (r = −0.54) and weakly correlated with distal lumbar lordosis (dLL) (r = −0.16). Thoracic kyphosis (T1–T12) was moderately correlated with pLL (r = −0.35) and dLL (r = −0.29). dLL was moderately correlated with LL (r = 0.64). 2.6% (12/468) of subjects had lumbar apex at L2, 40.2% (188/468) at L3, 56.6% at L4 (265/468), and 0.6% (3/468) at other levels. Mean PI was different between volunteers with the apex at L3 and L4. A lower mean PI was associated with the apex at L4 (49.0°), whereas a higher mean PI was associated with the apex at L3 (55.8°). The mean PI−LL mismatch for volunteers was −5.4° with a range from −35° to 39.7°. PI−LL mismatch increased from a mean of −10.1° in volunteers with low PI to a mean of 2.2° in volunteers with high PI. Age was not correlated with LL (P = 0.84).

Conclusions.
In asymptomatic adult volunteers, pLL showed a moderate correlation with PI and increased with PI, whereas dLL showed a weak correlation. The lumbar apex migrated proximally with increasing PI. Segmental lordosis and apex position instead of solely global lordosis should be emphasized.

Level of Evidence.
Level III.
Perinatal Disorders and Small Birthweight Are Significantly Associated With Small Vertebral Neural Canal Size in a Contemporary Pediatric Autopsy Sample
Authors: O’Donnell Lexi , Corron Louise K. , Hill Ethan C. 
Published: March 2023

Study design.
A retrospective, nonblinded, single-center observational study.

Objective.
The purpose of this study is to examine associations between small vertebral neural canal (VNC) measurements with verified experiences of early-life stress (ELS) (premature birth, disorders or conditions arising in the perinatal period, and congenital disorders) in a pediatric autopsy sample, paired with other skeletal indicators of stress, and known demographic/health information.

Summary of Background Data.
Most studies linking small VNC size to ELS are for human remains from archeological sites without known demographic information or health history, making it difficult to assess what kind of stress might affect VNC growth.

Methods.
This is a single-center retrospective study in a pediatric autopsy sample of 623 individuals (aged 0.5 to 20.9 yr) with known sex, age, and manner of death (MOD), who died between 2011 and 2019. Data were collected from postmortem computed tomography scans, autopsy, and field investigator reports. Data include VNC anteroposterior and transverse (TR) diameters of the 12th thoracic (T12) and fifth lumbar (L5) vertebrae, bone mineral density, and Harris lines.

Results.
Small birthweight males have significantly smaller VNC than those with an average birthweight. The natural MOD is associated with smaller VNC. Perinatal disorders and growth stunting are associated with smaller T12 anteroposterior, T12-TR, and L5-TR diameters. Congenital disorders and Harris lines are not associated with small VNC.

Conclusions.
Reduced VNC size is a reliable indicator of severe ELS, but not all ELS leads to reduced VNC. Females appear less susceptible to perinatal environmental stress than males. Reduced VNC may also be indicative of heightened risk of disease and death in those who died of natural MOD.

Level of evidence.
Level 2
Intraoperative Spinal Cord Stimulation Mitigates Central Sensitization After Spine Surgery in Mice
Authors: Yamamoto Satoshi , Duong Alexander , Kim Alex , Hu Chengrui , Wiemers Blaine , Wang Jigong , Chung Jin Mo , La Jun-Ho 
Published: March 2023

Study Design.
Double-blinded, prospective laboratory animal study.

Objective.
To examine whether intraoperative spinal cord stimulation (SCS) inhibits the development of spine surgery–induced hypersensitivity.

Summary of Background Data.
Managing postoperative pain after spine surgery is challenging, and as many as 40% of patients may develop failed back surgery syndrome. Although SCS has been shown to effectively reduce chronic pain symptoms, it is unknown whether intraoperative SCS can mitigate the development of central sensitization that causes postoperative pain hypersensitivity and potentially leads to failed back surgery syndrome after spine surgery.

Materials and Methods.
Mice were randomly stratified into three experimental groups: (1) sham surgery, (2) laminectomy alone, and (3) laminectomy plus SCS. Secondary mechanical hypersensitivity was measured in hind paws using von Frey assay one day before and at predetermined times after surgery. In addition, we also performed a conflict avoidance test to capture the affective-motivational domain of pain at selected time points postlaminectomy.

Results.
Mice that underwent unilateral T13 laminectomy developed mechanical hypersensitivity in both hind paws. Intraoperative SCS applied to the exposed side of the dorsal spinal cord significantly inhibited the development of hind paw mechanical hypersensitivity on the SCS-applied side. Sham surgery did not produce any obvious secondary mechanical hypersensitivity in the hind paws.

Conclusions.
These results demonstrate that spine surgery for unilateral laminectomy induces central sensitization that results in postoperative pain hypersensitivity. Intraoperative SCS after laminectomy may be able to mitigate the development of this hypersensitivity in appropriately selected cases.
Gastric Cross-Sectional Area to Predict Gastric Intolerance in Critically Ill Patients: The Sono-ICU Prospective Observational Bicenter Study
Authors: El Khoury Daniel , Pardo Emmanuel , Cambriel Amelie , Bonnet Francis , Pham Tai , Cholley Bernard , Quesnel Christophe , Verdonk Franck 
Published: March 2023

OBJECTIVES:
To evaluate the correlation between gastric cross-sectional area (GCSA) and the occurrence of gastric intolerance in critically ill patients within 24 hours of the measurement.

DESIGN:
Two-center prospective observational study.

SETTING:
Two academic ICUs in France between June 2020 and August 2021.

PATIENTS:
All surgical intubated ICU patients greater than or equal to 18 years old receiving enteral feeding for greater than 12 hours.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Forty-four patients were included, 11 (25%) of whom presented digestive intolerance. Primary outcome was assessment of the association between GCSA and the occurrence of gastric intolerance within 24 hours of the measurement. GCSA value was significantly higher in patients with upper digestive intolerance compared to those without (553 mm2 [interquartile range (IQR), 500–649 mm2] vs 970 mm2 [IQR, 777–1,047]; p < 0.001, respectively). The optimal threshold for predicting upper digestive intolerance was 720 mm2 (area under the receiver operating characteristic curve 0.86; positive predictive value 62.5%; negative predictive value 96.4%; sensibility 0.91; and specificity 0.81). Multivariate analysis (weighted by propensity score), including known risk factors, showed that GCSA above the 720 mm2 threshold was independently associated with the occurrence of upper digestive intolerance (odds ratio, 1.85; 1.37–2.49; p < 0.0002). Measurement quality was “good” (i.e., liver, aorta, superior mesenteric vein, and pancreas were all visualized) in 81% of cases.

CONCLUSIONS:
Measurement of GCSA by ultrasound would allow prediction of gastric intolerance in critically ill patients. This should be confirmed by a prospective score validation and interventional trials.
lncRNA AC005224.4/miR-140-3p/SNAI2 regulating axis facilitates the invasion and metastasis of ovarian cancer through epithelial-mesenchymal transition
Authors: Xiong Tingchuan , Wang Yinghong , Zhang Yuan , Yuan Jianlin , Zhu Changjun , Jiang Wei 
Published: March 2023

Abstract

Background:
Ovarian cancer is one of the most widespread malignant diseases of the female reproductive system worldwide. The plurality of ovarian cancer is diagnosed with metastasis in the abdominal cavity. Epithelial-mesenchymal transition (EMT) exerts a vital role in tumor cell metastasis. However, it remains unclear whether long non-coding RNA (lncRNA) are implicated in EMT and influence ovarian cancer cell invasion and metastasis. This study was designed to investigate the impacts of lncRNA AC005224.4 on ovarian cancer.

Methods:
LncRNA AC005224.4, miR-140-3p, and snail family transcriptional repressor 2 (SNAI2) expression levels in ovarian cancer and normal ovarian tissues were determined using real-time quantitative polymerase chain reaction (qRT-PCR). Cell Counting Kit-8 (CCK-8) and Transwell (migration and invasion) assays were conducted to measure SKOV3 and CAOV-3 cell proliferation and metastasis. E-cadherin, N-cadherin, Snail, and Vimentin contents were detected using Western blot. Nude mouse xenograft assay was utilized to validate AC005224.4 effects in vivo. Dual-luciferase reporter gene assay confirmed the targeted relationship between miR-140-3p and AC005224.4 or SNAI2.

Results:
AC005224.4 and SNAI2 upregulation and miR-140-3p downregulation were observed in ovarian cancer tissues and cells. Silencing of AC005224.4 observably moderated SKOV3 and CAOV-3 cell proliferation, migration, invasion, and EMT process in vitro and impaired the tumorigenesis in vivo. miR-140-3p was a target of AC005224.4 and its reduced expression level was mediated by AC005224.4. miR-140-3p mimics decreased the proliferation, migration, and invasion of ovarian cancer cells. SNAI2 was identified as a novel target of miR-140-3p and its expression level was promoted by either AC005224.4 overexpression or miR-140-3p knockdown. Overexpression of SNAI2 also facilitated ovarian cancer cell viability and metastasis.

Conclusion:
AC005224.4 was confirmed as an oncogene via sponging miR-140-3p and promoted SNAI2 expression, contributing to better understanding of ovarian cancer pathogenesis and shedding light on exploiting the novel lncRNA-directed therapy against ovarian cancer.