bluuebunny/crossref_metadata_2025_split huggingface dataset:
mRNA lipid nanoparticles induce immune tolerance to treat human diseases
Authors: Cao Wei , Xia Tian 
Published: April 2023

Abstract
Rapid developments in the coronavirus disease 2019 (COVID-19) mRNA vaccine showcased the power of lipid nanoparticle (LNP) delivery systems in fighting infectious diseases. In addition, mRNA therapeutics are also in development for cancer immunotherapy. Recently, mRNA therapy has been expanded to induce immune tolerance, the opposite of immune-boosting effects, to treat diseases involving enhanced immune responses including allergies and autoimmune diseases. mRNA LNPs have been used to treat peanut allergy by us and autoimmune experimental autoimmune encephalomyelitis by Ugur Sahin. It is expected that more and more research is going to delve into the immune tolerance field for allergies and autoimmune diseases, where effective therapies are in short supply.
Oat thermoplastic starch nanocomposite films reinforced with nanocellulose
Authors: Mohd Thani Nurfatimah , Mohamad Mazlan Mazween , Haris Nur Izzah Nabilah , Wondi Mohd Hafizz 
Published: April 2023

Abstract
With the urgent need to curb plastic pollution, research and development in biodegradable plastic have received a great deal of attention. Starch film is the most promising alternative to conventional petroleum-based plastic. It is biodegradable, affordable, and non-toxic to human health and the environment. Over the last decade, much attention has been paid to cellulose nanofiller-reinforcement to the starch-based polymer to produce nanocomposites. While the use of oat as nano-reinforcement is quite well known, there is still limited studies that investigate the use of nanocellulose for oat starch nanocomposite films reinforcement. There is an ample of possibility in improving the properties of oat starch films, and therefore utilizing nanocellulose reinforcement should be further investigated.
A systematic DFT study of arsenic doped iron cluster AsFe
n
(n = 1–4)
Authors: Das Shayeri , Ranjan Prabhat , Chakraborty Tanmoy 
Published: April 2023

Abstract
The research on metallic clusters in relevance to its far-reaching involvement in the high technology sector, solid-state physics and catalysis is an interesting and significant field of study. In this report, the investigation of arsenic doped iron cluster, AsFe
n
(n = 1–4) aided by conceptual density functional theory (CDFT) method has been performed. CDFT based global descriptors-mainly HOMO–LUMO energy gap and other parameters of these clusters are worked out. Obtained data shows that band energy gap varies in the magnitude of 1.451–3.138 eV. Uppermost magnitude of HOMO–LUMO energy gap i.e. 3.138 eV is observed for AsFe while AsFe4 show the smallest energy gap. It is noted that band gap of these systems decreases with increase in the cluster size, ‘n’. Direct association concerning both parameters HOMO–LUMO energy gap and molecular hardness of AsFe
n
clusters have been found. It indicates that among the studied compound AsFe is the most stable system whereas AsFe4 is the least stable. Dipole moment of the clusters is observed in the variation of 2.303 Debye to 3.853 Debye, signifying that the bond within the clusters is ionic in nature. The computed bond length between Fe–Fe in AsFe
n
is in agreement with the experimental data.
Phytochemical components and GC–MS analysis of Petiveria alliaceae L. fractions and volatile oils
Authors: Adesanya Enitan Omobolanle , Oyesiku Olubunkunola Oluwole , Adesanya Olumide Olatunde , Ogunlakin Akingbolabo Daniel , Odugbemi Adeshina Isaiah , Egieyeh Samuel Ayodele 
Published: April 2023

Abstract
Phytochemical constituents are important in the determination of plant activities. Their presence in medicinal plants gives their therapeutic values. These phytoconstituents possesses pharmacological activities that include antimicrobial, antioxidant, anti-inflammatory, analgesics, anti-diabetic, anti-hypertensive, antidiarrheal and several other activities. These activities can be determined by the identification of the phytochemicals present in medicinal plants. Petivera alliaceae L. is one of the medicinal plants in the family of phtytolaccaceae used traditionally as an antirheumatic, analgesics, antimicrobial, anticancer and immunomodulators. It is believed to possess rich phytoconstituents especially sulphur containing a broad-spectrum antimicrobial activity. Although the root extracts is been explored but there are limited publication to its root fractions. Therefore, the study is aimed at screening phytochemicals present in the fractions and volatile oil of the root parts of P. alliaceae using qualitative tests and Gas Chromatography–Mass Spectrometry (GC–MS) analysis. Fresh root parts of Petivera allliaceae plant were collected and air-dried. The dried root parts was macerated in absolute methanol for 72 h. The solution was extracted and dried. The dried root methanol extract was partitioned into n-hexane (PAH) and methanol fractions (PAM), while volatile oil (PAO) was extracted using Clevenger-type hydrodistillation method. The result shows that alkaloids, saponins and flavonoids were present while cardiac glycosides, phenol, terpenoids and anthraqunione glycosides were absent in both fractions. The GC–MS analysis identified 18 compounds in PAH, 19 compounds in PAM and 28 compounds in PAO. The fractions and volatile oils of P. alliaceae roots are rich in phytochemical constituents and compounds should be isolated from the fractions and explored for their potentials.
Scientific Literacy-Based Flipped Classroom Virtual Strategy for Biology Learning in the New Normal Era
Authors: Ridlo S. , Marina H. , Sapitri D. , Hadiyanti L. N. , Listyono L. 
Published: April 2023

Various research results concerned with flipped classrooms reported to mandate more benefits to form a positive attitude, self-efficacy, and self-regulated learning and affect students' abilities and skills. This research, which involved three studies, aims to develop a flipped classroom strategy model for virtual biology learning. The research was conducted in three high schools and the Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Semarang, at the beginning of the new normal habit of the COVID-19 pandemic. The analysis results of study 1 were applied in designing study 2, and the results of study 2 were applied to develop the model in study 3. The results showed that the flipped strategy was proven to improve skills employing information technology to benefit learning and student participation. The flipped strategy is proven to have better effects on learning outcomes and students' self-efficacy. The strategy model, arranged with asynchronous-synchronous-asynchronous in scientific literacy-based learning syntax and practiced with flipped e-learning instructions, is an ideal flipped classroom model. It is well appreciated by validators, teachers, and students and has proven to function well.
COVID-19 and Pediatric Mental Health Hospitalizations
Authors: Khan Jahidur Rahman , Hu Nan , Lin Ping-I , Eapen Valsamma , Nassar Natasha , John James , Curtis Jackie , Rimmer Maugan , O’Leary Fenton , Vernon Barb , Lingam Raghu 
Published: April 2023

OBJECTIVES
To analyze Australian national data to examine the impact of the coronavirus disease 2019 (COVID-19) pandemic on mental health-related hospital presentations among children and adolescents during the pandemic period with restrictions, and the period after the restrictions eased.

METHODS
We analyzed the monthly mental health-related inpatient admissions and emergency department (ED) attendances data from 6 large pediatric hospitals across Australia, using the Bayesian structural time series models. The COVID-19 restriction period was from March 2020 to December 2021 and the COVID-19 restriction-eased period from January to June 2022.

RESULTS
A total of 130 801 mental health-related hospital admissions (54 907) and ED attendances (75 894) were analyzed. During the COVID-19 restriction period, there was a significant increase in inpatient admissions related to deliberate self-harm behaviors (82%, 95% credible interval [CrI], 7%–160%) and ED attendances related to overall mental health disorders (15%, 95% CrI, 1.1%–30%) and eating disorders (76%, 95% CrI, 36%–115%). The increase was higher among females and those living in the least socioeconomically disadvantaged areas, suggesting a widening gap between mental health-related presentations by sex and socioeconomic status. After the restrictions eased, there were slight declines in mental health-related hospital presentations; however, the numbers remained higher than the pre–COVID-19 levels.

CONCLUSIONS
The increase in mental health-related hospital presentations during the COVID-19 period calls for additional support for pediatric mental health care, particularly for eating disorders and deliberate self-harm among female adolescents. It is important to monitor pediatric mental health service use as we enter “COVID-19 normal” period.
A realidade pastoral na cultura digital
Authors: Rocha de Souza Alzirinha 
Published: April 2023

Este texto é resultante da conferência de mesmo título apresentada no IV Seminário de Eclesiologia e Questões Pastorais, promovido pela PUCRS. Nele refletimos sobre as possíveis formas de recompor as comunidades após o período da pandemia. Certamente, o uso das mídias digitais e canais de transmissão naquele momento foi essencial. No entanto, é urgente perguntar quais mudanças são novamente necessárias para recompormos o nosso rosto primeiro de Igreja, que é sermos comunidade. Nesse sentido, é a partir de duas chaves de leitura interligadas (a saber: a recuperação da comunidade e a compreensão do deslocamento pastoral) que propomos nossa reflexão.
Protective effect of sesamol on cognitive impairment in APP/PS1 mice
Authors: Xu Y.L. , Zhang Y.D. , Wang Z.P. , Chen W.W. , Fan C. , Xu J.Q. , Wang T. , Rong S. 
Published: April 2023

AbstractTo explore the effect of sesamol on the cognition of APP/PS1 mice, 8-week-old APP/PS1 and wild-type male mice were divided into AD model group, AD + sesamol (50 mg kg−1 bw) group, and Control group. Sesamol was orally administered once a day for 5 months. Morris water maze was used to evaluate the learning and memory ability of mice. The number of synapses in the hippocampal neurons was detected by Golgi staining. Nissl staining was used to observe the changes of Nissl bodies in CA1 and CA3 regions of the hippocampus. Western blotting was used to detect the expression of Aβ, SIRT1, BDNF, and p-CREB/CREB in the hippocampus and cortex. Compared with the model group, sesamol decreased the latency period of APP/PS1 mice (P < 0.05) and increased the total number of neuronal dendritic spines in the hippocampal CA3 region, as well as increased the number of Nissl bodies (P < 0.05). Western blotting results showed that sesamol significantly reduced Aβ protein expression in the hippocampus and cortex, increased SIRT1 expression in the cortex, and increased BDNF expression in the hippocampus (P < 0.05). Sesamol improved the learning and memory abilities of APP/PS1 mice probably through increasing the density of neuronal dendritic spines and upregulating the levels of SIRT1 and BDNF.
Descrevendo o estresse
Authors: Santos Juliana Da Costa , Santos Maria Luiza Da Costa 
Published: April 2023

<p>O estresse sempre fez parte do cotidiano do ser humano, desde a pré-história, onde o homem tinha que procurar abrigo para proteger-se de chuvas, animais selvagens, caçar para sobreviver, até os dias atuais, apesar dos problemas serem diferentes. O homem contemporâneo possui situações ameaçadoras que representam fontes de estresse como: falta de tempo, preocupação com contas e impostos a pagar, pressões sociais e organizacionais, situação econômica, competição no mercado de<br />trabalho etc. Desta forma, o estresse faz parte das relações do homem com o mundo externo. Considerando a relevância desse tema, o presente artigo tem a pretensão de fazer uma revisão teórica sobre esse assunto, abordando, inicialmente, definições, fases do estresse, Fisiologia do Sistema de Adaptação Geral, estímulos estressores internos e externos.</p>
Desenvolvendo a habilidade para o desenho de esboço no Curso Superior de Tecnologia em Design de Interiores do CEFET-PB
Authors: Junior Aarão Pereira de Araújo , Rego Rogéria Gaudêncio do 
Published: April 2023

<p>Este trabalho apresenta os resultados dos estudos desenvolvidos para o Mestrado em Educação do Programa de Pós-Graduação em Educação da Universidade Federal da Paraíba, tendo como objeto de estudo o Esboço como conte ̇do e como ferramenta de desenvolvimento de desenhos e da criatividade na disciplina de Desenho Artístico do Curso Superior de Tecnologia em Design de Interiores do CEFET-PB. Neste trabalho, foram determinadas as contribuições deste tipo de desenho para a formação profissional do aluno, através de pesquisa de campo, sendo observada a própria disciplina de Desenho Artístico, aplicação de questionários e entrevistas com alunos e professores do curso em questão, análise dos planos de curso das disciplinas que possuem o conte ̇do do Esboço em seus currículos. Para as analises da habilidade adquirida ao longo da disciplina Desenho Artístico, utilizou-se como referência o modelo de Edwards (2000), que define cinco habilidades básicas para desenvolver o desenho.</p>
Formação de equipe: mito ou realidade?
Authors: Santos Maria Luiza Da Costa , Miranda Neto João Henrique De 
Published: April 2023

<p>O termo "equipe" vem sendo aplicado a diferentes tipos de grupos de trabalho. Em geral, uma equipe È um grupo de funcionários responsáveis pela elaboração total de um produto ou pelo fornecimento de um serviço completo e, constituindo-se como tal, todos os seus membros conhecem as tarefas que lhes são atribuídas e costumam ter autoridade para implementar, e não apenas para recomendar, iniciativas específicas relacionadas à melhoria da qualidade e da produtividade. Neste trabalho, o tema formação de equipe é abordado em forma de questionamento e tem como objetivo verificar se as organizações realmente estão preocupadas na formação e organização de equipes, como elas funcionam e quais são os resultados por essa estratégia apresentados. Trata-se, pois, de um estudo, inicialmente, teórico com fins de fundamentar a pesquisa de campo realizada em duas organizações, uma de natureza privada, empresa São Braz e outra de natureza pública, Detran. Ambas, com traços culturais próprios, apresentam uma característica comum relacionada a perspectiva de mudança para seus modelos gerenciais, os quais apontam a formação de equipes como uma estratégia de garantia de comprometimento e de resultados competitivos. A análise dos dados foi qualitativa, tomando como base o depoimento dos funcionários que compuseram a amostra. Levando em conta os fundamentos conceituais estudados neste trabalho, os resultados indicam que nem todos os respondentes estão conscientes do que È trabalhar em equipe, o que nos leva a concluir que, na prática, o trabalho em equipe é muito mais um mito do que propriamente uma<br />realidade.</p>
Resenha do Livro Hilando Fino: Desde el Feminismo Comunitario
Authors: Rabelo Borges Kellen Irene 
Published: April 2023

O livro “Hilando Fino: desde el feminismo comunitario”1. Nas primeiras páginas dessa obra, encontramos uma presentación a la segunda edición e Prólogo a la edición mexicana. E a organização da discussão está dividida assim: Introducción; 1 Pateando el tablero: [1.1 Para recibir el alma, ajayu del cambio, hay despachar el fantasma del neoliberalismo; 1.2 Em la quemadadel neoliberalismo estuvimos todas; 1.3 El entroque patriarcal]; 2 Uma ruptura epistemológica com el feminismo occidental [2.1El Chacha-Womi no es varita mágica que barra las discriminaciones; 2.2 El par complementario del feminismo comunitário; 2.3 ¿Qué cosa es entonces la comunidad?]; 3 ¡¡Ahora es cuando!! [3.1 Cuerpo; 3.2. Espacio; 3.3 Tiempo; 3.4 Movimiento (Organizaciones y Propuestas Políticas); 3.5 La memoria] Conclusiones
Revisão Narrativa Acerca do Conceito de Ansiedade em Psicologia
Authors: Evangelista de Araújo Beatriz 
Published: April 2023

A ansiedade trata-se de uma condição que, ao ser vivenciada de maneira exacerbada, causa intenso sofrimento psíquico; diferentes elementos podem desencadeá-la ao longo da vida do sujeito. Desse modo, o presente estudo investigou as produções científicas que foram produzidas nos últimos 5 anos sobre a temática da ansiedade na psicologia. A fim de alcançar esse objetivo, realizou-se uma revisão narrativa da literatura, atentando-se para a metodologia utilizada, os procedimentos feitos e a perspectiva utilizada paraabordar a ansiedade. Conclui-se que, na literatura, há uma predominância de estudos que propõe investigar a sintomatologia da ansiedade, utilizando-se de diferentes instrumentos de avaliação para verificar e validar seus resultados, além disso, alguns trabalhos abordam a ansiedade associada a outras condições como depressão e/ou estresse. Poucas pesquisas dedicam-se a estudar somente a ansiedade. Ademais, percebe-se que há escassez de pesquisas de abordagem qualitativas e com foco não somente na sintomatologia, mas na experiência da ansiedade para aquele que a vivencia. Portanto, faz-se necessário a produção de estudos voltados para essa temática.Palavras Chave: Ansiedade. Transtorno de ansiedade. Psicologia. Fenomenologia.
AUDIT FEES AND COMPANIES’ ACCESS TO FINANCE
Authors: Kalanjati Devi Sulistyo , Bramantio Reyhan Ario 
Published: April 2023

This paper aims to study the impact of audit fees on companies' ability to access finance by reducing their capital constraints. This study employs a dataset of listed non-financial Indonesian companies from 2016 to 2020. Unlike previous studies, which mostly examined this phenomenon in developed economies, this paper focuses on a country with a two-tier corporate governance model where the capital market is not a major source of financing and the disclosure of audit fees is still voluntary. In such a setting, the decision to disclose audit fees is in the hand of the companies' management, and various motivations behind the decision will differently impact different users of financial information. This paper focuses on whether the information related to audit fees is a good signal for capital providers. Following the limited attention theory, this study argues that capital providers will consider the information about audit fees as a more reliable proxy for audit efforts that subsequently affect their investment decision. The hypothesis is that audit fees are negatively associated with companies' financial constraints. The findings indicate that capital providers see higher audit fees as signals of high-quality audits that enhance the credibility of financial statements and positively impact companies' access to finance.

Key Words: Audit Fees, Capital Constraint, Access to Finance, Audit Quality, Limited Attention Theory
PELATIHAN PEMBUATAN POUCH ANYAMAN DENGAN TEKNIK DECOUPAGE BAGI GURU SLBN 1 YOGYAKARTA
Authors: Laila Nurul Himmah  , Mahanani Chytra , Sepsilia Elvera Resi , Eka Putri Gina 
Published: April 2023

ABSTRAK.
Pendidik memiliki peranan yang sangat penting dalam proses menentukan pengembangan potensi anak berkebutuhan khusus sesuai dengan kondisi dan kebutuhan referal anak berkebutuhan khusus, guru sekolah luar biasa (SLB) merupakan guru yang profesional dalam bidang pengetahuan anak berkebutuhan khusus. Hal ini tidak terlepas dari sebuah kreativitas guru untuk selalu memberikan sebuah inovasi, contohnya dengan memanfaatkan pouch anyaman pandan dijadikan sebuah produk dengan teknik decoupage sehingga memiliki nilai jual yang tinggi. Tujuan kegiatan ini adalah meningkatkan kreativitas pembuatan hiasan pouch anyaman yang memiliki nilai jual, memberikan pengetahuan pembuatan pouch anyaman dengan teknik decoupage dan menanamkan jiwa kewirausahaan guru SLB Negeri 1 Yogyakarta sehingga mampu menghasilkan produk yang banyak diminati konsumen, memberikan pengetahuan tentang usaha busana meliputi perhitungan harga jual, dan strategi pemasaran. Kegiatan ini dilaksanakan dengan metode ceramah, demonstrasi, pelatihan dan praktik. Berdasarkan hasil dari pembuatan produk ketika praktik, peserta sangat antusias mempraktekkan materi yang diberikan. Hasil praktik peserta pun bervariasi yakni masing-masing peserta membuat kreasi motif yang berbeda dengan mengkombinasikan berbagai macam motif tissue decoupage. Peserta meningkatkan pengetahuan teknik decoupage melalui proses kreativitas dan inovatif dalam rangka meningkatkan pendapatan dan dapat menyebar-luaskan kepada siswa dan siswi SLB. Melalui pelatihan ini para guru memiliki keterampilan untuk meningkatkan kualitas sumber daya manusia yang dapat dijadikan bekal membuka usaha sekaligus menciptakan lapangan kerja.
Traducción agroalimentaria alemán-español / español-alemán: el etiquetado del vino y su marco jurídico
Authors: Ramírez Almansa Isidoro 
Published: April 2023

El presente trabajo se centra en la traducción alemán-español / español-alemán del etiquetado del vino y de los diferentes productos vitivinícolas. Para ello, en primer lugar, analizaremos el concepto de etiquetado según la ley europea. Posteriormente, llevaremos a cabo una exhaustiva revisión de la normativa tanto sectorial como horizontal a nivel nacional y europeo ya se de obligado cumplimiento o facultativa. De esta forma, podemos determinar cuáles son los requisitos legales que el etiquetado del vino y demás productos vitivinícolas debe cumplir y cómo estos afectan a su traducción. Finalmente, analizaremos el etiquetado de dos botellas de vino, uno en alemán y otro en español. En dicho análisis se examinará los elementos del etiquetado y cómo estos deben traducirse cumpliéndose en todo momento la normativa vigente.

The current work focuses on the German-Spanish / Spanish-German translation of wine labelling and other wine sector products. To this end, we first analyze the definition of labelling according to European law. Later on, we carry out a detailed review of both sectoral and horizontal regulations at national and European level, whether mandatory or optional. In this way, we may establish what are the legal requirements that the labelling of wine and other wine sector products must meet, and how they affect its translation. Finally, we analyze the labelling of two wine bottles —one in German and the other one in Spanish—. In this analysis, the different elements present in the labelling are analyzed, as well as how these should be translated in compliance with current regulations.