bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bevacizumab suppressed degenerative changes in articular cartilage explants from patients with osteoarthritis of the knee
Authors: Sotozawa Masaichi , Kumagai Ken , Ishikawa Kimi , Yamada Shunsuke , Inoue Yusuke , Inaba Yutaka 
Published: January 2023

AbstractBackgroundThis study was designed to test the hypothesis that blockade of vascular endothelial growth factor (VEGF) suppresses degenerative changes in articular cartilage from patients with osteoarthritis (OA).MethodsArticular cartilage from eight OA patients was subjected to explant culture for 2 days in the presence or absence of 10 ng/ml recombinant interleukin (IL)-1β. The blocking effect of VEGF was examined by the addition of 10 or 100 ng/ml of bevacizumab. The culture media were harvested, and markers for cartilage degradation were measured by sandwich enzyme-linked immunoassay. Total RNA was isolated from cartilage tissues, and gene expressions associated with the anabolic response were examined by the quantitative real-time polymerase chain reaction.ResultsBevacizumab significantly reduced concentrations of matrix metalloproteinase (MMP)-2, MMP-3, and cartilage oligomeric matrix protein in the culture media with and without IL-1β. Significant suppressive effects of bevacizumab on MMP-9 and MMP-13 were shown only in the presence of IL-1β. Gene expression of Col2a1 was significantly increased by the addition of bevacizumab in the absence of IL-1β.ConclusionBevacizumab inhibits catabolic reactions and stimulates anabolic function in articular cartilage derived from OA patients directly, suggesting a protective effect on articular cartilage from OA progression.
Individual immune cell and cytokine profiles determine platelet-rich plasma composition
Authors: Niemann Marcel , Ort Melanie , Lauterbach Luis , Streitz Mathias , Wilhelm Andreas , Grütz Gerald , Fleckenstein Florian N. , Graef Frank , Blankenstein Antje , Reinke Simon , Stöckle Ulrich , Perka Carsten , Duda Georg N. , Geißler Sven , Winkler Tobias , Maleitzke Tazio 
Published: January 2023

Abstract
Objective
Platelet-rich plasma (PRP) therapy is increasingly popular to treat musculoskeletal diseases, including tendinopathies and osteoarthritis (OA). To date, it remains unclear to which extent PRP compositions are determined by the immune cell and cytokine profile of individuals or by the preparation method. To investigate this, we compared leukocyte and cytokine distributions of different PRP products to donor blood samples and assessed the effect of pro-inflammatory cytokines on chondrocytes.

Design
For each of three PRP preparations (ACP®, Angel™, and nSTRIDE® APS), products were derived using whole blood samples from twelve healthy donors. The cellular composition of PRP products was analyzed by flow cytometry using DURAClone antibody panels (DURAClone IM Phenotyping Basic and DURAClone IM T Cell Subsets). The MESO QuickPlex SQ 120 system was used to assess cytokine profiles (V-PLEX Proinflammatory Panel 1 Human Kit, Meso Scale Discovery). Primary human chondrocyte 2D and 3D in vitro cultures were exposed to recombinant IFN-γ and TNF-α. Proliferation and chondrogenic differentiation were quantitatively assessed.

Results
All three PRP products showed elevated portions of leukocytes compared to baseline levels in donor blood. Furthermore, the pro-inflammatory cytokines IFN-γ and TNF-α were significantly increased in nSTRIDE® APS samples compared to donor blood and other PRP products. The characteristics of all other cytokines and immune cells from the donor blood, including pro-inflammatory T cell subsets, were maintained in all PRP products. Chondrocyte proliferation was impaired by IFN-γ and enhanced by TNF-α treatment. Differentiation and cartilage formation were compromised upon treatment with both cytokines, resulting in altered messenger ribonucleic acid (mRNA) expression of collagen type 1A1 (COL1A1), COL2A1, and aggrecan (ACAN) as well as reduced proteoglycan content.

Conclusions
Individuals with elevated levels of cells with pro-inflammatory properties maintain these in the final PRP products. The concentration of pro-inflammatory cytokines strongly varies between PRP products. These observations may help to unravel the previously described heterogeneous response to PRP in OA therapy, especially as IFN-γ and TNF-α impacted primary chondrocyte proliferation and their characteristic gene expression profile. Both the individual’s immune profile and the concentration method appear to impact the final PRP product.

Trial registration
This study was prospectively registered in the Deutsches Register Klinischer Studien (DRKS) on 4 November 2021 (registration number DRKS00026175).
MBi-GRUMCONV: A novel Multi Bi-GRU and Multi CNN-Based deep learning model for social media sentiment analysis
Authors: Başarslan Muhammet Sinan , Kayaalp Fatih 
Published: January 2023

AbstractToday, internet and social media is used by many people, both for communication and for expressing opinions about various topics in many domains of life. Various artificial intelligence technologies-based approaches on analysis of these opinions have emerged natural language processing in the name of different tasks. One of these tasks is Sentiment analysis, which is a popular method aiming the task of analyzing people’s opinions which provides a powerful tool in making decisions for people, companies, governments, and researchers. It is desired to investigate the effect of using multi-layered and different neural networks together on the performance of the model to be developed in the sentiment analysis task. In this study, a new, deep learning-based model was proposed for sentiment analysis on IMDB movie reviews dataset. This model performs sentiment classification on vectorized reviews using two methods of Word2Vec, namely, the Skip Gram and Continuous Bag of Words, in three different vector sizes (100, 200, 300), with the help of 6 Bidirectional Gated Recurrent Units and 2 Convolution layers (MBi-GRUMCONV). In the experiments conducted with the proposed model, the dataset was split into 80%-20% and 70%-30% training-test sets, and 10% of the training splits were used for validation purposes. Accuracy and F1 score criteria were used to evaluate the classification performance. The 95.34% accuracy of the proposed model has outperformed the studies in the literature. As a result of the experiments, it was found that Skip Gram has a better contribution to classification success.
Asian students in the anglosphere – unravelling the unique familial pressures contributing to eating pathology: a systematic review
Authors: Sun Victor , Soh Nerissa , Touyz Stephen , Maguire Sarah , Aouad Phillip 
Published: January 2023

Abstract
Background
There is no clear consensus on the specific familial pressures affecting Asian students in the Anglosphere, despite the validation of the Tripartite Influence model of eating disturbances in this group. However, traditional familial risk factors for disordered eating can be elevated for immigrant Asians with collectivistic-oriented familial dynamics, necessitating an examination of the culture-specific risk profile for eating pathology in student-aged Asians. This systematic review aims to consolidate and critically examine the literature on the most widely studied familial pressures related to disordered eating in Asian students in the Anglosphere.

Methods
A systematic search was conducted in five databases for peer-reviewed articles measuring familial pressures and eating pathology in Asian students > 10 years old from an Anglosphere country. Following PRISMA guidelines, papers were screened by title, abstract and full text based on the eligibility criteria. Eligible studies were qualitatively analysed and synthesised narratively to assess the relationship between familial pressures and eating pathology.

Results
In total, 14 papers were eligible for inclusion in the review. Eight topics related to familial stressors were identified (1) intergenerational conflict; (2) lack of familial cohesion; (3) parental overprotection; (4) low parental care; (5) familial achievement orientation; (6) parental expectations; (7) parental criticism; and (8) direct parental influence. In multiple studies, intergenerational conflict, maternal overprotection, and familial achievement orientation were significantly elevated and associated with disordered eating in US and UK Asian students, compared to white students. The studies examining parental criticism and familial cohesion had more heterogeneous findings.

Conclusion
The findings demonstrate the perception of Asian parenting styles as overprotective and incompatible with individualist-oriented Western values could increase eating pathology in adolescent and university students living in Anglosphere countries. The synthesised findings of the literature also indicate disordered eating acts as a compensatory mechanism for the ongoing psychological distress generated from intergenerational conflict and familial achievement orientation. Conversely, traditional eating disorder literature on familial cohesion and low parental care may not be applicable to young Asians. Future research should focus on how social appearance anxiety and psychological factors can mediate the link between disordered eating and familial stressors in Asian students.
Traumatised and on TikTok: from inside the psych ward
Authors: Parsons Damon 
Published: January 2023

SUMMARYFaster internet speeds and ever-present mobile phones present a new challenge to psychiatric wards – the ability for patients to live stream their in-patient stays. What are the benefits and the risks to the patient streaming and the ward as a whole? This article is to help start a conversation about this unique problem and how health professionals might go about addressing it.
Beta and Coskewness Pricing: Perspective from Probability Weighting
Authors: Shi Yun , Cui Xiangyu , Zhou Xun Yu 
Published: January 2023

Does Subjective Evaluation of Probability Impact Asset Prices? The Nobel Prize–winning capital asset pricing model (CAPM) predicts that expected excess return of any asset is positively proportional to its exposure to the overall market: the beta, leading to an upward-sloping security market line. However, this prediction is contradicted by empirical studies that the return–beta slope is often flat or even downward-sloping, a puzzle called the “beta anomaly.” The CAPM is premised upon the notion that market participants are all rational, including that they are able to objectively evaluate probabilities. However, evidence abounds that individuals are often unable to do so, examples being purchase of lottery tickets and insurance products, in which the extremely small probabilities of winning or losing big are exaggerated. This phenomenon of distorting probabilities at both tails is called “probability weighting” (PW), which is a key component of modern behavioral finance. The paper “Beta and Coskewness Pricing: Perspective from Probability Weighting” approaches the beta anomaly through PW. It offers an explanation of the beta anomaly via a new theoretical CAPM involving PW and an extensive empirical study.
Metasurface design with a complex residual neural network
Authors: Liu Kaizhu , Sun Changsen 
Published: January 2023

In recent years, researchers have made great progress in solving complex electromagnetic field computing problems by using deep learning methods. However, the approaches found in literature were devoted to solving the real-number problem of electromagnetic field calculations. For the complex number problem, there was no good solution. Here, we proposed an advanced computation method for metasurfaces based on a complex residual neural network (CRNN). We predicted the scattering

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parameters of a cylindrical structure in the range of 1.2 to 1.7 µm wavelengths. By providing a set of cylindrical structure parameters, we could quickly predict the

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parameters with CRNN and design a metalens, which proved the ability of the proposed method. In addition, our method can also be extended to the calculation of electromagnetic fields where the speed of the calculation of the complex number of metasurfaces should be accelerated.
Advancing the Study of Experiential Learning: Toward Evidence-Based Effectiveness
Authors: Bansal Utkarsh , Sorek Gaya , Wittman Sarah 
Published: January 2023

In the modern education system, individuals are raised from an early age to adhere to learning processes focused around the hypo- thetical. Such conceptual learning, however, has recently been found to be less effective than a comparable style of learning called Experiential Learning, which is the process of learning by doing. By engaging students in hands-on experiences and reflection, they are better able to connect theories and knowledge learned in the classroom to real-world situations. However, the flexibility of Experiential Learning leaves it open to a wide range of interpretations, which does not establish a consistent bench- mark.
This research project focuses on establishing a concrete definition for Experiential Learning through the analysis of various experimental sce- narios and how it is measured in the post-secondary learning environ- ment. Taking into consideration the inductive processes we utilize to code our collected data, as well as the criteria we collect to filter our data. Such work would benefit a large part of the population through a more effective learning process and will allow other researchers to determine whether scenarios and other experiences fit the criteria to be evaluated as an experiential learning setting as well as design experiments that better reflect experiential learning as a whole.
Correlation among Poincare plot and traditional heart rate variability indices in adults with different risk levels of metabolic syndrome: a cross-sectional approach from Southern India
Authors: Endukuru Chiranjeevi Kumar , Gaur Girwar Singh , Yerrabelli Dhanalakshmi , Sahoo Jayaprakash , Vairappan Balasubramaniyan , Goud Alladi Charanraj 
Published: January 2023

AbstractObjectivesHeart rate variability (HRV) is an important marker of cardiac autonomic modulation. Metabolic syndrome (MetS) can alter cardiac autonomic modulation, raising the risk of cardiovascular disease (CVD). Poincaré plot analysis (PPA) is a robust scatter plot-based depiction of HRV and carries similar information to the traditional HRV measures. However, no prior studies have examined the relationship between PPA and traditional HRV measures among different risk levels of MetS. We evaluated the association between the Poincare plot and traditional heart rate variability indices among adults with different risk levels of MetS.MethodsWe measured anthropometric data and collected fasting blood samples to diagnose MetS. The MetS risk was assessed in 223 participants based on the number of MetS components and was classified as control (n=64), pre-MetS (n=49), MetS (n=56), and severe MetS (n=54). We calculated the Poincaré plot (PP) and traditional HRV measures from a 5 min HRV recording.ResultsBesides the traditional HRV measures, we found that various HRV indices of PPA showed significant differences among the groups. The severe MetS group had significantly lower S (total HRV), SD1 (short-term HRV), SD2 (long-term HRV), and higher SD2/SD1. The values of S, SD1, SD2, and SD2/SD1 were significantly correlated with most traditional HRV measures.ConclusionsWe found gradual changes in HRV patterns as lower parasympathetic and higher sympathetic activity alongside the rising number of MetS components. The HRV indices of PPA integrating the benefits of traditional HRV indices distinguish successfully between different risk levels of MetS and control subjects.
Long-term experience with the use of a single histrelin implant beyond one year in patients with central precocious puberty
Authors: Ray Lauren A. , Eckert George J. , Eugster Erica A. 
Published: January 2023

Abstract

Objectives
The histrelin implant has been used to treat central precocious puberty (CPP) for more than 15 years. Although approved for annual use, limited published reports suggest that a single implant is efficacious well beyond a year. Our objective was to report our long-term experience using a single histrelin implant for more than 12 months in children with CPP.

Methods
We performed a retrospective study of 170 children with central precocious puberty treated with a single histrelin implant for more than 1 year.

Results
Implants were left in situ for an average of 24 months. Pubertal development regressed or remained stable in the vast majority of patients and biochemical suppression was maintained. No correlation between time since an implant was placed and complications such as implant breakage or a second incision was seen.

Conclusions
A single histrelin implant provides excellent pubertal suppression well beyond a year. Extended use of a single histrelin implant should be considered standard of care in children with CPP.
Grundlagen der Gasfeuchte Teil 1 (Sättigungsverhalten von Wasser in einem Trägergas)
Authors: Mitter Helmut 
Published: January 2023

ZusammenfassungWasser als wichtiger Bestandteil der Atmosphäre ist zusammen mit der Energie der Sonne hauptverantwortlich für die meisten Wettererscheinungen und wird oft qualitativ als ,,Feuchte” wahrgenommen. Es kann unter natürlichen Umgebungsbedingungen auf der Erde als einzige chemische Verbindung in allen drei Aggregatzuständen fest, flüssig und gasförmig auftreten. Auch in Prozessgasen kann der Wasseranteil für das Gelingen eines Prozesses von Bedeutung sein. In diesem Fall tritt Feuchte auch in anderen Gasen als Luft auf. Für eine quantitative Beschreibung weg vom qualitativen Zugang ist es deshalb wichtig, möglichst genaue Daten für das thermodynamische Wechselspiel von Wasser in seinen drei natürlich vorkommenden Phasen im jeweiligen Matrixgas zu haben. Als erster Schritt wird das Sättigungsverhalten von Wasser in reiner Phase, d.h. bei Abwesenheit anderer Gase, untersucht und verschiedene theoretische Ansätze zur Beschreibung des Sättigungsverhaltens über Wasser und Eis skizziert. Schließlich werden Formeln hoher Genauigkeit zur Beschreibung des Sättigungsverhaltens sowie mathematisch einfachere Näherungsformeln angegeben. Anschließend wird das Sättigungsverhalten von Wasser in einem Matrixgas (bzw. Trägergas) beschrieben und Formeln für das Verhalten von Wasser im Matrixgas ,,trockene Luft” angegeben. Das Verhalten von Wasser in anderen Matrixgasen wie Methan, Erdgas, Kohlendioxid und Schwefelhexafluorid wird skizziert und weiterführende Literatur angegeben.
DynH

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O: Aufbau zur metrologischen Charakterisierung der dynamischen Eigenschaften von Hygrometern
Authors: Witt Felix , Schuchard Malte , Ebert Volker 
Published: January 2023

Abstract
A novel flow switching setup for the dynamic generation and metrological detection of fast, isolated H2O concentration changes is presented and characterized. Based on this flow setup, very accurate, static H2O concentrations as well as highly dynamic H2O step changes of several 1000 ppmv (µmol/mol) can be generated and repeated. First experiments show that temporal water vapor concentration gradients of up to 10000 ppmv/s can be generated and measured. Based on this setup, a dynamic hygrometer characterization method was developed and demonstrated using a polymer-based hygrometer as device under test (DUT). The polymer hygrometer (with about 180 ppmv/s) proved to be more than 15 times slower than the optical reference hygrometer (with 3000 ppmv/s) and could be modeled and described well with a first order lowpass. To estimate the dynamics of the spatial and temporal H2O-profile, a fast, traversable, local sampling probe was developed and used in combination with a fast, extractive laser hygrometer (called SEALDH-II). The modeling of the H2O distribution in the dynamically operated flow channel enables the calculation of the dynamic concentration at the position of the DUT based on the data of the spatially averaging open-path laser reference hygrometer. In the future, this calculation will be used to determine a transfer function between the optical, open path reference hygrometer and the position of the DUT in order to extract the ideal step response of the DUT from the measured data of the flow channel.
EXPLORING THE INFLUENCE OF SERVICE QUALITY (SQ) ON PATIENT SATISFACTION (PS): A CASE STUDY OF UNIVERSITI MALAYSIA PAHANG HEALTH CENTRE (UMPHC)
Authors: Khairul Salleh Abdul Basit  , Suhaidah Hussain  
Published: January 2023

Patient satisfaction and healthcare service quality has been studied for ages. Primary care centre such as UMP Health Centre (UMPHC) is the intermediaries between patients and hospital referral. Hence, they have the most contact and influence on customers because they are convenient and strategic, and become the primary direct contact with patients on a daily basis, especially the university community. As healthcare organizations are trying to improve their return on investment, UMPHC has started to implement steps in curbing patient dissatisfaction issues with the study of service quality and patient satisfaction. In this paper, the author looks into the dimensions of service quality that influence patient satisfaction in their visits and appointments at UMPHC. The impact of various service quality dimensions on patient satisfaction is studied to understand how those factors relate to the patient’s expectations and perceptions. In this qualitative case study, semi-structured interviews were conducted with fourteen students and four staff who visited UMPHC and the results were analyzed through thematic analysis. In this research, seven themes namely responsiveness, reliability, assurance, empathy, tangible, technical quality, and elements that could improve patient satisfaction are created which further branches to a total of 21 sub-themes. The location of UMPHC or accessibility to the services, dental services, staff’s attitude and communication skills, consistency in following the standard operating procedures, waiting time, technical quality as well as health education were amongst the most important factors affecting patient satisfaction. The UMPHC health managers are recommended to focus on the above aspects and implement appropriate management decisions to improve patient satisfaction.
The Role of Indonesian Diplomacy in Managing the Conflict between The Myanmar Government and The Rohingya Muslim Ethnic
Authors: Rasyid Sulaiman , Prabandari Adya Paramita , Daren Bastian Chris , Simanjuntak Christopher 
Published: January 2023

The Rohingya population after Myanmar's independence has experienced a continuous decline this is due to several actions ranging from deportation to killings, until now only a few Rohingya Muslims remain in Rakhine. Basically, the conflict between the Rohingya and Rakhine is more about race than religion. The United Nations (UN) said that the Rohingya are the most oppressed ethnic group in the world. The purposes of this research are beside to analyze the role of Indonesian diplomacy in overcoming the conflict between the Rohingya Muslim Ethnic and the Myanmar Government, it also analyze the Indonesian government effort on Rohingnya case in the perspective International Law. The diplomatic strategy carried out by Indonesia in the issue of the Rohingya ethnic conflict with the Myanmar government, namely the submission of a humanitarian proposition and the proposed equation 4 + 1 for the Rohingya community in the future. Then, Indonesia also used the OIC as the largest international Islamic organization to pressure and urge Myanmar to immediately resolve the violence against the Rohingya. Lastly, diplomacy in the form of providing strategic assistance to the Rohingya ethnicity and participation of the Indonesian people in voicing the resolution of the conflict in Myanmar with the mass media.