bluuebunny/crossref_metadata_2025_split huggingface dataset:
A potential cost of evolving epibatidine resistance in poison frogs
Authors: York Julia M. , Borghese Cecilia M. , George Andrew A. , Cannatella David C. , Zakon Harold H. 
Published: January 2023

AbstractBackgroundSome poison arrow frogs sequester the toxin epibatidine as a defense against predators. We previously identified a single amino acid substitution (S108C) at a highly conserved site in a neuronal nicotinic acetylcholine receptor (nAChR) ß2 subunit that prevents epibatidine from binding to this receptor. When placed in a homologous mammalian nAChR this substitution minimized epibatidine binding but also perturbed acetylcholine binding, a clear cost. However, in the nAChRs of poison arrow frogs, this substitution appeared to have no detrimental effect on acetylcholine binding and, thus, appeared cost-free.ResultsThe introduction of S108C into the α4β2 nAChRs of non-dendrobatid frogs also does not affect ACh sensitivity, when these receptors are expressed inXenopus laevisoocytes. However, α4β2 nAChRs with C108 had a decreased magnitude of neurotransmitter-induced currents in all species tested (Epipedobates anthonyi, non-dendrobatid frogs, as well as human), compared with α4β2 nAChRs with the conserved S108. Immunolabeling of frog or human α4β2 nAChRs in the plasma membrane using radiolabeled antibody against the β2 nAChR subunit shows that C108 significantly decreased the number of cell-surface α4β2 nAChRs, compared with S108.ConclusionsWhile S108C protects these species against sequestered epibatidine, it incurs a potential physiological cost of disrupted α4β2 nAChR function. These results may explain the high conservation of a serine at this site in vertebrates, as well as provide an example of a tradeoff between beneficial and deleterious effects of an evolutionary change. They also provide important clues for future work on assembly and trafficking of this important neurotransmitter receptor.
Comparison of characteristics between adolescent and adult pregnant women who used methamphetamine: a retrospective study in a tertiary hospital
Authors: Ratta-apha Woraphat , Jinanarong Vinn , Sirikunchoat Jingswat , Tasneeyapant Piangmas , Prachgosin Punyisa , Sa-guanpanich Naratip 
Published: January 2023

Purpose
This study aims to examine the characteristics of pregnant women who used methamphetamine to determine the differences in characteristics between teenagers (aged under 20 or 20–25 years) and adult women who used methamphetamine during this period.

Design/methodology/approach
This retrospective study extracted data from the medical records of obstetric patients who gave birth between 2011 and 2015 in a tertiary hospital in Thailand. All included patients were diagnosed with amphetamine use disorder. Demographic data, history of antenatal care, history of substance use and psychiatric evaluations were recorded.

Findings
Four hundred and twelve patients were recruited for analysis. Of these, 194 (53.4%) did not attend regular antenatal care, 326 (92.1%) had unplanned pregnancies and 42 (12.5%) had a history of abortions. Socially, 47 patients (21.7%) reported drug use in their families and 160 (49.5%) reported a history of parental separation. Compared with the adult and 20–25 years groups, the < 20 years group tended to have a lower educational level, have experienced parental separation and had more regular antenatal care.

Research limitations/implications
Pregnant teenagers with methamphetamine use had psychosocial difficulties. Physicians should be aware of these psychosocial issues, including education and family planning.

Originality/value
These findings showed that pregnant women who used methamphetamine faced psychosocial difficulties, unplanned pregnancies and inadequate antenatal care. Adult and teenage pregnant women who used methamphetamine differed in some ways. For example, teenage pregnant women tended to be of a lower education level, experienced parental separation and had a history of more frequent antenatal care. Further longitudinal research exploring the outcomes of mothers who used methamphetamine and their children is needed to build on the existing evidence.
Goa Institute of Management: campus water sustainability projects
Authors: Mahtani Umesh , Amarnani Arpita Neeraj , Sukhathankar Vithal 
Published: January 2023

Learning outcomes
▪ Students learn how an educational institute impacts water resources on the campus and its surrounding community.
▪ Students acquire knowledge on how decision-making, related to natural resources, is influenced by the institute’s obligations towards surrounding communities and the long-term sustainability of the resources.
▪ Students become acquainted with the decision-making process adopted by an educational institute for achieving resource-efficient development on the campus.
▪ Students learn how to design evaluation methods for investments related to water conservation at an educational institute.
▪ Students become proficient with the payback method specifically when evaluating water-enhancing projects at an educational campus.

Case overview/synopsis
Dr Ajit Parulekar, Director at Goa Institute of Management (GIM), Goa, India, was evaluating options to improve the sources of water at GIM at the beginning of 2021. He was reviewing the projects proposed to meet the water requirement at the campus for the next five years (2021–2025). The projects were recommended by consultants (ENV Consultants Pvt Ltd) who proposed a total expenditure of US$68,667 which involved storage enhancement and water table upgradation (See Case Exhibit 11). The maintenance department had studied the plans but their projections showed that the execution of these projects and initiatives would still lead to a deficit of water in the future. Dr Parulekar reviewed the reports and weighed the expected tangible and intangible benefits from the proposed projects. The projects had to be carefully selected, keeping in mind the multiple objectives to be met: an increase in water supply within a short time, a financially optimum investment and a minimum impact on the surrounding community. The selected projects had to meet the long-term sustainability objective of resource efficiency at the campus.

Complexity academic level
Students studying finance, project appraisal, campus sustainability at graduate or postgraduate management programs.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 4: Environmental Management.
LinkedIn as a pedagogical tool for careers and employability learning: a scoping review of the literature
Authors: Healy Michael , Cochrane Sandra , Grant Paula , Basson Marita 
Published: January 2023

PurposeProfessional networks are conduits for career insight, vehicles for career exploration and incubators of professional identity. Accordingly, LinkedIn is a rich environment for university students' careers and employability learning. In this article, the authors review how the pedagogical use of LinkedIn has been conceived, implemented and evaluated in higher education research.Design/methodology/approachThe authors conducted a scoping literature review on research articles and chapters investigating the use of LinkedIn for careers and employability learning. The authors conducted a systematic database search and screened the results, resulting in 30 eligible studies. Each study was analysed for research characteristics, theoretical foundations, reported affordances or outcomes and critical concerns.FindingsThe authors find little evidence of cohesion or consistency in the existing research. Studies draw on different theoretical and methodological approaches and use different measures of networking behaviours and competencies. Studies tend not to consider ethical concerns about using LinkedIn as a pedagogical tool.Practical implicationsThe authors argue this is not yet a body of research that supports the synthesis necessary for a reliable evidence base. The authors recommend that educators employing LinkedIn in the curriculum ground their work in more coherent, cohesive and integrated theories of careers and employability learning.Originality/valueThis review summarises a body of literature on the use of LinkedIn as a pedagogical tool for careers and employability learning in higher education. This review describes and critiques the beginnings of an evidence-base from which educators can further investigate how students can be supported to develop their online professional networking skills.
The impact of tourism on the women employment in South American and Caribbean countries
Authors: Voumik Liton Chandra , Nafi Shohel Md. , Majumder Shapan Chandra , Islam Md. Azharul 
Published: January 2023

Purpose
This study aims to explore the relationship between tourism and women’s employment in 32 South American and Caribbean countries from 1996 to 2020.

Design/methodology/approach
In this paper, both static (fixed effects and random effects) and dynamic panel data models (system and differenced generalized method of moments) are used. In addition to gross domestic product, trade, education and urban population are also considered in this study.

Findings
According to the findings, a boost in tourism led to an increase in women’s engagement in the economy and service sectors. This paper also explores the efficiency of alternate methods to deal with various models of women labor force (WLF) involvement in various sectors. Women’s employment opportunities in the service sector expand as a result of tourism, but in the agricultural and industrial sectors, that employment opportunity is reduced.

Research limitations/implications
This study investigated the impact of tourism on WLF participation and found that it had a significant impact. This study, on the other hand, specifically contributed to the tourism sector in some specific study areas, such as tourism and agriculture, service and industry sectors. This study also displays that female participation in South America and the Caribbean countries is increasing and women are shifting away from traditional economic sectors.

Originality/value
This is the pioneering study to discover tourism and female participation in employment in South American and Caribbean countries. The findings of this study have important implications for future studies and policy debates examining the consequence of the tourism industry on WLF.
Family incivility, emotional exhaustion, and hotel employees’ outcomes: a moderated mediation model
Authors: Yan Zhen , Mansor Zuraina Dato , Choo Wei Chong 
Published: January 2023

Purpose
This study aims to analyze the impact of family incivility (FI) on in-role performance (IRP) and proactive customer service performance (PCSP) via the mediating effect of emotional exhaustion (EE) and the moderating roles of emotional intelligence (EI) and mindfulness.

Design/methodology/approach
Hypotheses were verified using multisource and multiwave data collected from 337 valid hotel employee–supervisor dyads in Kuala Lumpur, Malaysia. Data were analyzed using SPSS 24.0, AMOS 24.0 and PROCESS (version 3.4).

Findings
FI intensified frontline employees’ (FLEs) EE, which subsequently impeded their IRP and PCSP. EI and mindfulness moderated the direct influence of FI on EE, IRP and PCSP and moderated the indirect influence of FI on the two aforementioned outcomes through EE.

Practical implications
Managers should observe FLEs’ indicators of FI and deter its emergence by implementing care programs for FLEs suffering from FI. In addition, human resource managers should preferentially recruit employees with high EI through related tests. Hotels can invite reputable psychologists to provide psychotherapy interventions for FLEs, such as mindfulness-based psychological lectures and therapy.

Originality/value
The hospitality literature lacks an understanding of the underlying process through which FI affects FLEs’ job outcomes. This study incorporates EE as a mediator of the FI’s impact on IRP and PCSP, and to the best of the authors’ knowledge, this study is the first to assess whether EI and mindfulness moderate the direct impact of FI on IRP and PCSP and the indirect impact of FI on two aforementioned outcomes via EE.
Is supply chain finance an antidote to SMEs in the economic crisis? - A qualitative inquiry
Authors: Kaur Jaspreet , Kumar Satish , Joshi Rohit 
Published: January 2023

PurposeThis exploratory study aims to explore the operational and financial constraints faced by small and medium enterprises (SMEs) in India during the COVID-19 pandemic. The paper highlights the role of supply chain finance (SCF) in the uncertain business environment caused by the pandemic.Design/methodology/approachThe study adopts an inductive approach and conducts convergent interviews with 32 SME owners and bank officials who are associated with SME-related financial transactions. The analysis of the interview data has been done through a grounded theory approach.FindingsThe findings portray four key themes representing the operational and financial constraints faced by SMEs during the pandemic. Further, the study identifies four drivers of SCF adoption among SMEs, including capital constraints, high inventory turnover cycle time, high order fulfilment cycle time and long debtors’ collection period.Practical implicationsThe study provides various insights to the managers and owners of SMEs to deal with the economic crisis and eliminate the financial pressure created by the pandemic. The study enlightens the policymakers about the struggles of the SMEs during the economic turmoil created by the pandemic and guides them to introduce the relevant policies to resolve their problems.Originality/valueTo the best of the authors’ knowledge, this is the first study to identify the factors driving the SMEs to adopt SCF due to the economic chaos created by the pandemic. Also, the study theoretically contributes to the literature by developing a theoretical framework for SCF adoption based on grounded theory.
Susceptibility to interference between Pavlovian and instrumental control predisposes risky alcohol use developmental trajectory from ages 18 to 24
Authors: Chen Hao , Belanger Matthew J. , Garbusow Maria , Kuitunen‐Paul Sören , Huys Quentin J. M. , Heinz Andreas , Rapp Michael A. , Smolka Michael N. 
Published: January 2023

AbstractPavlovian cues can influence ongoing instrumental behaviour via Pavlovian‐to‐instrumental transfer (PIT) processes. While appetitive Pavlovian cues tend to promote instrumental approach, they are detrimental when avoidance behaviour is required, and vice versa for aversive cues. We recently reported that susceptibility to interference between Pavlovian and instrumental control assessed via a PIT task was associated with risky alcohol use at age 18. We now investigated whether such susceptibility also predicts drinking trajectories until age 24, based on AUDIT (Alcohol Use Disorders Identification Test) consumption and binge drinking (gramme alcohol/drinking occasion) scores. The interference PIT effect, assessed at ages 18 and 21 during fMRI, was characterized by increased error rates (ER) and enhanced neural responses in the ventral striatum (VS), the lateral and dorsomedial prefrontal cortices (dmPFC) during conflict, that is, when an instrumental approach was required in the presence of an aversive Pavlovian cue or vice versa. We found that a stronger VS response during conflict at age 18 was associated with a higher starting point of both drinking trajectories but predicted a decrease in binge drinking. At age 21, high ER and enhanced neural responses in the dmPFC were associated with increasing AUDIT‐C scores over the next 3 years until age 24. Overall, susceptibility to interference between Pavlovian and instrumental control might be viewed as a predisposing mechanism towards hazardous alcohol use during young adulthood, and the identified high‐risk group may profit from targeted interventions.
DriveSafe DriveAware: A systematic review
Authors: Vito Erin , Barkla Anna , Coventry Linda 
Published: January 2023

AbstractObjectivesDriving is an activity of daily living that significantly affects independence, and driving cessation is associated with poor health, lower quality of life, cognitive decline and early entry into care facilities. There is no consensus regarding the best off‐road tool to assess driving safety. Therefore, this review explored the diagnostic accuracy, reliability and clinical utility of DriveSafe DriveAware (DSDA) compared with an on‐road driving assessment.MethodsThis review adhered to the PRISMA guidelines. Electronic databases for all English language articles published prior to December 2021 were searched. Studies were assessed for methodological quality and results were synthesised using a narrative descriptive approach.ResultsSix studies were reviewed, consisting of 1332 participants. Four studies assessed diagnostic accuracy, two studies assessed reliability and three were relevant to clinical utility since they used DSDA as a standalone tool. Some studies demonstrated high levels of diagnostic accuracy, with specificity and sensitivity above 90% for those who fall into the safe and unsafe categories (50% of those assessed). Inter‐rater reliability showed substantial agreement, and test–retest reliability was demonstrated for all age groups. DSDA was assessed as having high clinical utility (as a standalone tool) based on time taken to conduct, cost effectiveness and equipment required to complete the assessment.ConclusionsDriveSafe DriveAware appears to be an ideal tool for the subacute setting; however, at present, inadequate evidence exists to support its use as a standalone tool for directing driving decisions. Further research is required.
A Richards growth model to predict fruit weight
Authors: Gerhard Daniel , Moltchanova Elena 
Published: January 2023

SummaryThe Richards model comprises several popular sigmoidal and monomolecular growth curves. We illustrate fitting of a Bayesian Richards model by splitting the full growth model into several submodels, followed by a model selection procedure. The performance of the methodology is evaluated by Monte Carlo simulations. A double‐sigmoidal version of the Richards model is applied to model grape bunch weight based on data from a New Zealand vineyard over a single growing period.A Bayesian Richards growth model applied to grape size data. Representations of phenological processes are selected through multi‐model inference.
The role of the circadian clock in the development, progression, and treatment of non‐alcoholic fatty liver disease
Authors: de Assis Leonardo Vinicius Monteiro , Demir Münevver , Oster Henrik 
Published: January 2023

AbstractThe circadian clock comprises a cellular endogenous timing system coordinating the alignment of physiological processes with geophysical time. Disruption of circadian rhythms has been associated with several metabolic diseases. In this review, we focus on liver as a major metabolic tissue and one of the most well‐studied organs with regard to circadian regulation. We summarize current knowledge about the role of local and systemic clocks and rhythms in regulating biological functions of the liver. We discuss how the disruption of circadian rhythms influences the development of non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH). We also critically evaluate whether NAFLD/NASH may in turn result in chronodisruption. The last chapter focuses on potential roles of the clock system in prevention and treatment of NAFLD/NASH and the interaction of current NASH drug candidates with liver circadian rhythms and clocks. It becomes increasingly clear that paying attention to circadian timing may open new avenues for the optimization of NAFLD/NASH therapies and provide interesting targets for prevention and treatment of these increasingly prevalent disorders.
Calcium‐dependent modulation of BKCa channel activity induced by plasmonic gold nanoparticles in pulmonary artery smooth muscle cells and hippocampal neurons
Authors: Soloviev Anatoly , Ivanova Irina , Sydorenko Vadym , Sukhanova Khrystyna , Melnyk Mariia , Dryn Dariia , Zholos Alexander 
Published: January 2023

AbstractAimGold nanoparticles are widely used for biomedical applications, but the precise molecular mechanism of their interaction with cellular structures is still unclear. Assuming that intracellular calcium fluctuations associated with surface plasmon‐induced calcium entry could modulate the activity of potassium channels, we studied the effect of 5 nm gold nanoparticles on calcium‐dependent potassium channels and associated calcium signaling in freshly isolated rat pulmonary artery smooth muscle cells and cultured hippocampal neurons.MethodsOutward potassium currents were recorded using patch‐clamp techniques. Changes in intracellular calcium concentration were measured using the high affinity Ca2+ fluorescent indicator fluo‐3 and laser confocal microscope.ResultsIn pulmonary artery smooth muscle cells, plasmonic gold nanoparticles increased the amplitude of currents via large‐conductance Ca2+‐activated potassium channels, which was potentiated by green laser irradiation near plasmon resonance wavelength (532 nm). Buffering of intracellular free calcium with ethylene glycol‐bis‐N,N,N′,N′‐tetraacetic acid (EGTA) abolished these effects. Furthermore, using confocal laser microscopy it was found that application of gold nanoparticles caused oscillations of intracellular calcium concentration that were decreasing in amplitude with time. In cultured hippocampal neurons gold nanoparticles inhibited the effect of EGTA slowing down the decline of the BKCa current while partially restoring the amplitude of the slow after hyperpolarizing currents.ConclusionWe conclude that fluctuations in intracellular calcium can modulate plasmonic gold nanoparticles‐induced gating of BKCa channels in smooth muscle cells and neurons through an indirect mechanism, probably involving the interaction of plasmon resonance with calcium‐permeable ion channels, which leads to a change in intracellular calcium level.
The gut microbiota‐astrocyte axis: Implications for type 2 diabetic cognitive dysfunction
Authors: Li Zi‐Han , Jiang Ya‐Yi , Long Cai‐Yi , Peng Qian , Yue Ren‐Song 
Published: January 2023

AbstractBackgroundDiabetic cognitive dysfunction (DCD) is one of the most insidious complications of type 2 diabetes mellitus, which can seriously affect the ability to self‐monitoring of blood glucose and the quality of life in the elderly. Previous pathological studies of cognitive dysfunction have focused on neuronal dysfunction, characterized by extracellular beta‐amyloid deposition and intracellular tau hyperphosphorylation. In recent years, astrocytes have been recognized as a potential therapeutic target for cognitive dysfunction and important participants in the central control of metabolism. The disorder of gut microbiota and their metabolites have been linked to a series of metabolic diseases such as diabetes mellitus. The imbalance of intestinal flora has the effect of promoting the occurrence and deterioration of several diabetes‐related complications. Gut microbes and their metabolites can drive astrocyte activation.AimsWe reviewed the pathological progress of DCD related to the “gut microbiota‐astrocyte” axis in terms of peripheral and central inflammation, intestinal and blood–brain barrier (BBB) dysfunction, systemic and brain energy metabolism disorders to deepen the pathological research progress of DCD and explore the potential therapeutic targets.Conclusion“Gut microbiota‐astrocyte” axis, unique bidirectional crosstalk in the brain‐gut axis, mediates the intermediate pathological process of neurocognitive dysfunction secondary to metabolic disorders in diabetes mellitus.