bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enlarging symptomatic arachnoid cyst in an elderly patient: illustrative case
Authors: Sindewald Ryan W. , González Hernán F. J. , Brandel Michael G. , Steinberg Jeffrey A. 
Published: April 2023

BACKGROUND
Arachnoid cysts are congenital or acquired structures found within the brain and are rarely symptomatic for adults. The literature documenting enlarging arachnoid cysts in adults is also discussed.

OBSERVATIONS
An elderly woman presented with acutely worsening headaches, photophobia, cognitive function, and a seizure-like episode. The patient had a known arachnoid cyst with a decade of radiographic stability, which was now idiopathically enlarging. The patient had a previous history of traumatic brain injuries but no reported trauma around the time of presentation. Due to the severity of midline shift and symptomatology, the decision was made to treat the patient surgically with fenestration and shunting. She recovered well postoperatively.

LESSONS
During the workup for a symptomatic elderly patient, enlargement of a previously asymptomatic arachnoid cyst should remain on the differential until specifically ruled out, even in the absence of recent trauma. While rare, enlarging arachnoid cysts result in neurological findings and impact the quality of life for patients.
Livelihood strategies for widows and divorcees of coastal fishers in Indonesia
Authors: Subair Nurlina , Pidani Rita R. , Meiyani Eliza , Haris Risma , Irma Irma 
Published: April 2023

In Bugis-Makassar families with a patriarchal cultural system, men are the backbone of the family and women only work in the domestic realm. The main problem faced by widows and divorcees of coastal fishers is the dual role that requires them to take care of the household and children as well as earn a living for the needs of the family. This dual function requires a widow to have a strategy and carry out these two roles simultaneously. This study aims to find out how the strategies for making a living for widows of coastal fishers in improving the family economy. This study uses a qualitative approach with case study method. The data collection technique uses a purposive sampling for determining the informant and conducting in-depth interview technique with eight widows consisting of four widows and four divorcees. We also observed the daily activities of the informants. Meanwhile, the interview process was carried out using semi-structured interviews about how the strategy for earning a living was carried out so that it could support the family economy. The study found social capital-based livelihood strategies for poor fishers. They often interpret the strategy as a way or an alternative to a situation. In this case, the widow or divorcee of a coastal fisher is part of the community. Widows and divorcees who work in more than one type of work make their association with others as a form of social capital. Thus, they can provide support to each other as aform of social security and social capital to support the family.
Uma revisão integrativa da liderança em enfermagem no Brasil
Authors: Santos Marcia Rodrigues dos , Barros Carla Ferreira Rodrigues Dias , Silva Luciana Pinheiro Barbosa da 
Published: April 2023

A pesquisa sobre liderança em enfermagem cresceu na última década, com maior ênfase no papel dos gerentes/líderes de enfermagem nas organizações de saúde (CAI, W.et.al, 2019). A liderança é considerada uma das habilidades mais importantes que os profissionais de saúde adquirem. Segundo Vera Brasil (2017), a integração entre a capacidade crítica e reflexiva de saberes e de fazeres diversos é essencial e, portanto, necessária para os profissionais liderarem de forma eficaz e eficiente. Sabe-se que a atuação do enfermeiro está focada em aspectos assistenciais e gerenciais, o que o torna um profissional presente e necessário em diferentes serviços de saúde (MAIA et al., 2020). Sendo a gestão uma área designada para a coordenação e administração das tarefas e equipes (DIAS et al., 2021). Ademais, a formação de enfermeiros líderes têm tido destaque nas graduações em saúde para atuação nas organizações de saúde (MOURA, et al., 2019). Diante disso, nota-se a relevância ao pensar na atuação do enfermeiro na gestão, levando em consideração que uma boa gestão do setor está relacionada à qualidade do cuidado e assistência prestada à população. No contexto atual, o exercício da liderança representa uma realidade que permeia as condutas do enfermeiro, em virtude da frequente ocupação de cargos de chefia nos serviços de saúde. Segundo Maia (2020) a atuação do enfermeiro está focada em aspectos assistenciais e gerenciais, tornando-se um profissional presente e necessário em diferentes serviços de saúde. Portanto, há necessidade de compreender melhor o estilo de liderança dos gerentes de enfermagem no Brasil. O objetivo deste estudo foi analisar o estilo de liderança do enfermeiro no Brasil.
Impact of oil waste discharge from Al-Nassiriya oil refinery upon physical chemical properties and heavy elements content of vicinity soil
Authors: Bassim y. AL-khafaji  , Noora Q. Kareem  
Published: April 2023

The present study attempt to know the impact of oil waste discharge from Al-Nassiriya oil refinery upon some physical chemical properties and heavy elements (HEs) concentration in the vicinity soil , during the period from January until August 2020 . Some physical and chemical factors were measured also selected HEs ( Co , Ni , Pb and V ) concentration in the soil were measured by using Flam Atomic Absorption Spectrometry ( FAAS ) , in addition to soil texture and total organic carbon content were measured as percentage . The results revealed that the range of the soil parameters were , Temp.(16.3 – 44.3) ◦c , pH (6.0 - 8.7) , electrical conductivity E.C. (119.2-312.10) µs/cm , salinity (0.02 - 1.63) gm/kg , porosity (29 – 58) % , NO3 (7.91 - 97.5) mg /kg , PO4 (5.4 - 24.7) mg/ kg , SO4 (480 - 1739) mg/kg , while soil texture was silty clay at st.1 and st.2 , sandy loam at st.3 and silty loam at st.4 . Total organic carbon (TOC %) content and organic matter (OM%) were ranged from (3.89 - 17.52) % and (2.26 – 10.16) % respectively . HEs content in the soil of study were ranged from Pb (5.9 - 63.7 ) , Co (4.7 - 51.77) , V (36 - 181 ) and Ni (5.57 - 222 ) mg/kg dry weight respectively .
Improvement of The Photostability of Nimodipine by Using Liquisolid Compacts Technique
Authors: Mustafa E. Khazim  , Hamid J. Hasan  , Noor M. Hanoon  , Hussein A. Hussein Al-Sa’idy  
Published: April 2023

Liquisolid compacts are one of the modern drug formulation techniques used for drug formulation for several objectives including protection against photosensitivity. This study evaluates the photoprotective effect of the liquisolid compact technique on a calcium channel blocker antihypertensive drug, nimodipine, which is considered a photosensitive drug model. Liquisolid compact tablets of nimodipine were prepared from; Avicel PH-102 as a carrier material, (colloidal silicon dioxide, Cab-O-sil, and titanium dioxide as coating materials), croscarmellose sodium (CSS), sodium starch glycolate (SSG), crospovidone (CP) as super disintegrants, and propylene glycol as the liquid vehicle. However, the ratio of carrier to coating materials was kept constant in all formulations at 35:1. This ratio was chosen after testing the ratios 15:1, 20:1, 25:1, 30:1 and 35:1. The feasibility of the prepared liquisolid systems was also evaluated for first; the pre-compression and post-compression characteristics. Second, the possible drug-excipients interaction using FT-IR. Third, the photostability of Nimodipine in pure form, conventional tablets, and in the prepared liquisolid tablets through irradiation with a light dose of 0.55 W/m2/h visible light, 50 W/m2/h UVA and 0.27 W/m2/h UVB for 12 h in order to estimate the effect of coating material type on Nimodipine stability especially in the prepared liquisolid formulations. The results showed that all of the prepared liquisolid tablets showed satisfactory properties regarding pre and post-compression properties. Interestingly, the FTIR spectra study ruled out any interaction between nimodipine and excipients in the prepared liquisolid tablets. Besides, all of the prepared liquisolid tablets had shown a superior drug dissolution profile compared to the conventional and direct compressed tablets. Finally, 92.43% of the drug remaining was found in the liquisolid formulation (F7) after 12 h photo-irradiation as compared to 65.48% drug remaining for the pure drug substance and 75.12% for directly compressed tablets indicating that liquisolid technique had significantly inhibited the photo-degradative effect of light in the prepared liquisolid formulations. It can be concluded that the liquisolid compacts technique is a promising approach for the improvement of photostability of this photosensitive Nimodipine with an acceptable stability as well as enhanced dissolution rate.
Preparation of Hybrid Junction Light Emitting Device from Cadmium Sulphite Quantum dot/ poly-TPD Junction
Authors: Riyadh Mohammed Hussein , A. Ibrahim Omar 
Published: April 2023

Stratums of ITO/TPD:PMMA/CdS/Alq3/Al were used to make the hybrid nanoparticles light emitting diode (NPs-LED), which were created using the phase segregation method and the spin coating procedure. Light-generating NPs-LED hybrid device is composed of 3 stratums stacked in a certain order on an Indium tin oxide(ITO) substrate made of transparent conducting oxide. The first stratum was (N, N'-bis (3-methylphenyl)-N, N'-bis (phenyl) benzidine) (TPD) polymer, and polymethyl methacrylate (PMMA) polymer. Cadmium Sulphite (CdS) is the second stratum, while Tris (8-hydroxyquinolinato) aluminum (Alq3) is the last stratum, which is one of the materials used as electron injector stratums.
Various bias voltages (28, 30, and 32V) were used to examine the electroluminescence (EL) of NPs-LEDs at room temperature, depending on the CIE 1931 color spaces, `light was created at 32V, whereas blue light was generated at 28V. The transmission between sub levels in the energy gap of CdS NPs (surface state). Voltages are controlling the current change, and the knee voltage is 6.6 V, as seen by the current – voltage (I-V) distinctive. EL spectrum demonstrates a broadband emission spanning 300 nm to 700 nm. Finally, it is discovered that the correlated color temperature (CCT) is about (7450 to 11820k).
Yoğun Bakım Ünitesinde yatan Covid-19'lu Gebe ve Lohusaların Mortalite Risk Faktörleri
Authors: KILIÇ İsa , ADANAS AYDIN Gültekin , TURAN ÖZSOY Hilal Gülsm , ÜNAL Serhat 
Published: April 2023

Amaç: Bu çalışmada yoğun bakımda yatan COVID-19 tanılı gebe ve lohusalarda mortalite prediksiyon modeli oluşturarak APACHE II, SAPS II ve SOFA skorları ile karşılaştırılması amaçlanmıştır.
Gereç ve Yöntem: Hastanemizin COVID-19 yoğun bakım ünitelerine yatan Covid-19 tanısı doğrulanmış gebe ve lohusaların demografik, laboratuvar, radyolojik ve klinik verileri geriye dönük olarak kaydedildi.
Bulgular: Çalışmaya dahil edilen 50 hastadan 13’ü kaybedildi. Yaş ortalaması ölen grupta 35.54±4.24 yıl, yaşayan grupta 30.03±4.91 yıl idi (p=0.002). Lojistik regresyon modeli, yaş, lenfopeni, yüksek CRP ve IL-6 düzeylerinin mortalite ile ilişkili olduğunu ortaya koydu. Modelin mortalite (AUC) için prediktif gücü 0.946±0.045 (p
YOĞUN BAKIM ÜNİTESİNDE AKUT BÖBREK HASTALIĞI TANISI OLAN OLGULARDA HEMODİYALİZ TEDAVİSİNİN MORTALİTEYE ETKİSİ
Authors: DENİZ KAHVECİOĞLU Esra , ÖZTÜRK Yasin , AYHAN İhsan 
Published: April 2023

Amaç
Akut böbrek hastalığı (ABH), saatler-günler içinde böbrek fonksiyonlarının bozulması sonucu üremik toksinlere bağlı gelişebilen bir tablodur. Yoğun bakım ünitesindeki (YBÜ) hastalarda ABH gelişimi sık görülebilmektedir. Bu durum mortalite ve morbidite oranının artırmaktadır. Bu çalışmada YBÜ’de takip edilen ABH tanılı hastalarda, yapılan renal replasman tedavisinin (RRT) mortalite üzerindeki etkisini değerlendirmek amaçlandı.

Gereç ve Yöntem
Araştırmamız hastanemiz 1 ocak 2017 ile 31 aralık 2017 yılları arasında YBÜ’de ABH nedenli yatırılan veya yatışından sonra ABH gelişen 104 hasta retrospektif olarak incelendi. ERBP (European Renal Best Practice) kriterlerine göre ABH 3 evrede sınıflandırılmış ve APACHE II (Acut Physiology and Chronic Health Evaluation II) skorlaması ile mortalite riski arasındaki ilişki belirtilmiştir. Hastalar hemodiyaliz alan ve almayanlar olarak iki gruba ayrılarak analiz edildi.

Bulgular
Çalışmadaki hastaların 59.6%’sı erkek, 40.6%’si kadınlardan oluşmaktadır. Hastaların YBÜ’ ye yatış sebeplerini değerlendirdiğimizde ilk sırada enfeksiyonlar, ikinci sırada ise ABH oluşturmaktadır. ERBP sınıflamasına göre hastaların %76.9’u evre 3 ‘te yer almakta olup mekanik ventilatör desteği almaktadır. Evre 3 te yer alan hastalarda RRT ihtiyacının artığı gözlendi (p
Diagnosis of Thyroid Carcinoma - Dynamic Magnetic Resonance Imaging as a Problem Solver
Authors: AKAY Emrah , ERDOĞAN Nezahat , ULUÇ Engin 
Published: April 2023

Objective: Comparison of the diagnostic accuracy of dynamic magnetic resonance imaging (MRI) with color Doppler US and Fine Needle Aspiration Cytology (FNAC) in the differential diagnosis of thyroid carcinoma cases.
Materials and methods: Study group comprised 28 women and 6 men and all of them had thyroid hormone disorders in their routine examinations. 38 nodules were examined. After radiologic examinations, FNAC and thyroidectomy were applied.
Results: The dynamic MR was found to have the highest sensitivity and specificity between the color-Doppler US, FNAC, and dynamic MR modalities for the diagnosis of carcinoma. In the dynamic MR examination, the difference between the peak-contrast signal intensity values (p = 0.018) and the minimum-contrast signal intensity values (p = 0.023) calculated at the p < 0.05 level were statistically significant between the malignant and benign nodules.
Conclusions: We consider that the differential diagnosis of thyroid nodules can be made by analyzing the dynamic MRI data. Malignant thyroid nodules show typical time-signal intensity curves, and we believe that dynamic MRI will be valuable for preoperative assessment of the thyroid nodules in certain conditions like radiology–pathology mismatch.
Effects of stance control via hidden Markov model-based gait phase detection on healthy users of an active hip-knee exoskeleton
Authors: Sánchez-Manchola Miguel , Arciniegas-Mayag Luis , Múnera Marcela , Bourgain Maxime , Provot Thomas , Cifuentes Carlos A. 
Published: April 2023

Introduction: In the past years, robotic lower-limb exoskeletons have become a powerful tool to help clinicians improve the rehabilitation process of patients who have suffered from neurological disorders, such as stroke, by applying intensive and repetitive training. However, active subject participation is considered to be an important feature to promote neuroplasticity during gait training. To this end, the present study presents the performance assessment of the AGoRA exoskeleton, a stance-controlled wearable device designed to assist overground walking by unilaterally actuating the knee and hip joints.Methods: The exoskeleton’s control approach relies on an admittance controller, that varies the system impedance according to the gait phase detected through an adaptive method based on a hidden Markov model. This strategy seeks to comply with the assistance-as-needed rationale, i.e., an assistive device should only intervene when the patient is in need by applying Human-Robot interaction (HRI). As a proof of concept of such a control strategy, a pilot study comparing three experimental conditions (i.e., unassisted, transparent mode, and stance control mode) was carried out to evaluate the exoskeleton’s short-term effects on the overground gait pattern of healthy subjects. Gait spatiotemporal parameters and lower-limb kinematics were captured using a 3D-motion analysis system Vicon during the walking trials.Results and Discussion: By having found only significant differences between the actuated conditions and the unassisted condition in terms of gait velocity (ρ = 0.048) and knee flexion (ρ ≤ 0.001), the performance of the AGoRA exoskeleton seems to be comparable to those identified in previous studies found in the literature. This outcome also suggests that future efforts should focus on the improvement of the fastening system in pursuit of kinematic compatibility and enhanced compliance.
Glutamine coated titanium for synergistic sonodynamic and photothermal on tumor therapy upon targeted delivery
Authors: Zhang Lina , Zhu Pengfeng , Wan Ting , Wang Huaiyan , Mao Zhilei 
Published: April 2023

Introduction: The application of titanium dioxide nanoparticles (TiO2 NPs) for cancer therapy has been studied for decades; however, the targeted delivery of TiO2 NPs to tumor tissues is challenging, and its efficiency needs to be improved.Method: In this study, we designed an oxygen-deficient TiO2-x coated with glutamine layer for targeted delivery, as well as the enhanced separation of electrons (e-) and holes (h+) following the joint application of sonodynamic therapy (SDT) and photothermal therapy (PTT).Results: This oxygen-deficient TiO2-x possesses relatively high photothermal and sonodynamic efficiency at the 1064 nm NIR-II bio-window. The GL-dependent design eased the penetration of the TiO2-x into the tumor tissues (approximately three-fold). The in vitro and in vivo tests showed that the SDT/PTT-based synergistic treatment achieved more optimized therapeutic effects than the sole use of either SDT or PTT.Conclusion: Our study provided a safety targeted delivery strategy, and enhanced the therapeutic efficiency of SDT/PTT synergistic treatment.
Effect of corneal stiffness decrease on axial length elongation in myopia determined based on a mathematical estimation model
Authors: Ren Qi , Chu Zhe , Cui Wei , Cheng Lu , Su Wenjie , Cheng Hao , Wu Jie 
Published: April 2023

Purpose: To investigate the relationship between the corneal material stiffness parameter stress-strain index (SSI) and axial length (AL) elongation with varying severities of myopia, based on a mathematical estimation model.Methods: This single-center, cross-sectional study included data from healthy subjects and patients preparing for refractive surgery in the Qingdao Eye Hospital of Shandong First Medical University. Data were collected from July 2021 to April 2022. First, we performed and tested an estimated AL model (ALMorgan) based on the mathematical equation proposed by Morgan. Second, we proposed an axial increment model (ΔAL) corresponding to spherical equivalent error (SER) based on ALemmetropia (ALMorgan at SER = 0) and subject’s real AL. Finally, we evaluated the variations of ΔAL with SSI changes based on the mathematical estimation model.Results: We found that AL was closely associated with ALMorgan (r = 0.91, t = 33.8, p &lt; 0.001) with good consistency and SER was negatively associated with ΔAL (r = −0.89, t = −30.7, p &lt; 0.001). The association of SSI with AL, ALemmetropia, and ΔAL can be summarized using the following equations: AL=27.7−2.04×SSI, ALemmetropia=23.2+0.561×SSI, and ΔAL=4.52−2.6×SSI. In adjusted models, SSI was negatively associated with AL (Model 1: β = −2.01, p &lt; 0.001) and ΔAL (Model 3: β = −2.49, p &lt; 0.001) but positively associated with ALemmetropia (Model 2: β = 0.48, p &lt; 0.05). In addition, SSI was negatively associated with ΔAL among subjects with AL ≥ 26 mm (β = −1.36, p = 0.02).Conclusion: AL increased with decreasing SSI in myopia.
High absolute neutrophil count with type 2 diabetes is associated with adverse outcome in patients with coronary artery disease: A large-scale cohort study
Authors: He Jining , Lin Zhangyu , Song Chenxi , Zhang Rui , Wang Haoyu , Yuan Sheng , Bian Xiaohui , Dong Qiuting , Dou Kefei 
Published: April 2023

BackgroundInflammatory processes crucially modulate the development, progression, and outcomes of coronary artery disease (CAD). Since hyperglycemia could alter inflammatory responses, this study aimed to investigate the effect of ANC, a novel and rapidly available inflammatory biomarker, on the prognosis of patients undergoing PCI with or without type 2 diabetes (T2D).MethodsA total of 7,826 patients with CAD hospitalized for PCI at Fuwai Hospital were consecutively recruited. According to the median ANC value, patients were stratified as having high ANC (ANC-H) or low ANC (ANC-L) and were further classified into four groups by T2D. The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCEs), including all-cause mortality, myocardial infarction, stroke, and target vessel revascularization.ResultsDuring a median follow-up of 2.4 years, 509 (6.5%) MACCEs were documented. Diabetic patients with increased ANC were at significantly higher risk of MACCEs (aHR, 1.55; 95% CI, 1.21–1.99; P = 0.001) compared to those in the ANC-L/non-T2D group (P for interaction between T2D and ANC categories = 0.044). Meanwhile, multivariable regression analysis demonstrated the highest MACCE risk in diabetic patients with a higher level of ANC than others (P for trend &lt;0.001).ConclusionThis study suggests that stratification of patients with elevated ANC and T2D could provide prognostic information for CAD patients undergoing PCI.
Can the fNIRS-derived neural biomarker better discriminate mild cognitive impairment than a neuropsychological screening test?
Authors: Park Jin-Hyuck 
Published: April 2023

IntroductionEarly detection of mild cognitive impairment (MCI), a pre-clinical stage of Alzheimer’s disease (AD), has been highlighted as it could be beneficial to prevent progression to AD. Although prior studies on MCI screening have been conducted, the optimized detection way remain unclear yet. Recently, the potential of biomarker for MCI has gained a lot of attention due to a relatively low discriminant power of clinical screening tools.MethodsThis study evaluated biomarkers for screening MCI by performing a verbal digit span task (VDST) using functional near-infrared spectroscopy (fNIRS) to measure signals from the prefrontal cortex (PFC) from a group of 84 healthy controls and 52 subjects with MCI. The concentration changes of oxy-hemoglobin (HbO) were explored during the task in subject groups.ResultsFindings revealed that significant reductions in HbO concentration were observed in the PFC in the MCI group. Specially, the mean of HbO (mHbO) in the left PFC showed the highest discriminant power for MCI, which was higher than that of the Korean version of montreal cognitive assessment (MoCA-K) widely used as a screening tool for MCI. Furthermore, the mHbO in the PFC during the VDST was identified to be significantly correlated to the MoCA-K scores.DiscussionThese findings shed new light on the feasibility and superiority of fNIRS-derived neural biomarker for screening MCI.