bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Measurement of the Casimir force with a natural renormalization and a maximum vacuum frequency
Authors: Kulas Sascha 
Published: January 2023

Abstract

The Casimir force pushes two plates together in vacuum. This force still has a lot of unknown aspects. We measure the Casimir force in a tuning fork experiment with an additional metal plate. By changing the plates spacing we show that the amplitude of the Casimir force can be shifted. Moreover, we measure that the vacuum fluctuations which produce this effect are damped, with a minimum wavelength of around 0.17 mm. This behaviour acts as a natural renormalization. The maximum frequency of 1.76 THz would have an extensive impact. The cosmological constant problem would be strongly reduced because the vacuum energy density would have the same order than measured by cosmological constant experiments, instead of 120 orders.
Bacteroides uniformis regulates TH17 cell differentiation and alleviates chronic colitis by producing alpha-muricholic acid
Authors: Zhang Enping , Yan Yiting , Lei Yu , Qu Ying , Fan Zhen , Zhang Ting , Xu Yangbin , Du Qian , Brugger Daniel , Chen Yulin , Zhang Ke 
Published: January 2023

AbstractInflammatory bowel disease (IBD) cause colitis-associated malignancy. Studies have shown that IBD development is associated with dysbiosis of the gut microbiota using the IBD model of animals and humans.Bacteroides uniformis, the most abundant core strain in mammals, regulates animal intestinal homoeostasis. However, the key metabolic compounds and mechanism by whichB. uniformistreats colitis in mice are unknown. In this study,B. uniformisJCM5828-gavaged female C57BL/6 mice (n = 8) greatly alleviated the progression of DSS-induced colitisand restored the expression of mechanical and immune barrier proteins in the colon. Furthermore, increased abundance ofB. uniformisin the colon promoted the abundance of the symbiotic bacteriaBifidobacteriumandLactobacillus vaginalisand inhibited the ecological niche of pathogenicEscherichia coli, thus regulating intestinal lipid metabolism function. Specifically,B. uniformissignificantly increased the synthesis of primary and secondary bile acids (alpha-Muricholic acid (α-MCA), Isochenodeoxycholic acid (isoCDCA), hyodeoxycholic acid (HDCA), and isolithocholic acid (isoLCA)) in the colonic contents.B. uniformisalso significantly regulated the expression of key regulator genes and proteins of the NF-κB and MAPK signaling pathways in colonic tissues and inhibited TH17 differentiation.In vitrocellular validation showed that singleB. uniformiscould not significantly inhibit TH17 differentiation in T lymphocytes. In contrast, key metabolic molecules α-MCA, HDCA and isoLCA could inhibit TH17 differentiation in the lamina propria and regulate the intestinal immune response. Cumulatively, the results indicate thatB. uniformisJCM5828 supplementation may be an optional approach to the treat colitis and other diseases associated with intestinal barrier dysfunction.
Multi-layered epigenetic control of persistent and stage-specific imprinted genes in rice endosperm
Authors: Tonosaki Kaoru , Ono Akemi , Nagata Hiroki , Furuumi Hiroyasu , Nonomura Ken-ichi , Sato Yutaka , Comai Luca , Hatakeyama Katsunori , Kawakatsu Taiji , Kinoshita Tetsu 
Published: January 2023

Abstract

In the offspring, imprinted genes show differential expression from the maternal and paternal alleles. Our time-course analysis in rice (Oryza sativa) revealed persistent and stage-specific classes of imprinted genes, including over a hundred novel genes, especially in the early stage of endosperm development. In the persistent maternally expressed genes (MEGs), CG and CHG sequences are heavily methylated, while these sites are less methylated in the stage-specific MEGs. Similarly, differences in H3K27me3 defined the two classes of paternally expressed genes (PEGs). The imprinting for MEGs involves activating silent genes. By contrast, many PEGs are active in various tissues and carry gene body DNA methylation (gbM); the maternally inherited alleles of these PEGs undergo silencing via gbM demethylation and deposition of H3K27me3. Stage-specific imprinting indicates that parental marks can be differentially interpreted during development. Its developmental variability contrasts the robustness of persistent imprinting, revealing the dynamic layering of parental effects and suggesting new mechanisms for evolution and manipulation of rice endosperm development.
Comparison of predictive effect of the dietary inflammatory index and empirically derived food-based dietary inflammatory index on the menopause-specific quality of life and its complications.
Authors: Haghshenas Niloufar , Baharanchi Fatemeh Hosseini , Melekoglu Ebru , Sohouli Mohammadhassan , Shidfar Farzad 
Published: January 2023

Abstract
Introduction:
Menopause, defined as the cessation of menstruation for at least 12 months, is one of the important stages of a woman's life cycle. Some hormonal variations occur during the transition to menopause, which affects women’s quality of life. Recently, the role of dietary factors in alleviating symptoms has been investigated.
Aim of this study:
We tried to investigate the relationship between dietary inflammatory index (DII), food-based dietary inflammatory index (FDII) and quality of life, and menopausal symptoms, comparing their predictive power and suggesting the best cut-off point.
Methodology:
149 postmenopausal women were included in the cross-sectional study. After collecting data by interview, the desired variables were calculated. Logistic regression and ROC curves were used to investigate the relationship and predictive power of DII and FDII with menopausal symptoms.
Findings:
We observed that both DII and FDII were significantly associated with the severity of sexual symptoms. The first tertile of DII (OR = 0.252, P-value = 0.002) and FDII (OR = 0.316, P-value = 0.014) had a significantly lower odds ratio for severe to moderate symptoms compared to the third tertile. Both inflammatory indices had significant predictive power in predicting the probability of having severe to moderate poor quality of life (FDII (p-value = 0.004) > DII (p-value = 0.006)) and sexual symptoms (DII (p-value = 0.002) > FDII (p-value = 0.003)). Also, regarding the physical subtype, only FDII (p-value = 0.002) results were significant.
Conclusion
Both dietary inflammatory indices appear to be suitable for predicting quality of life, but FDII had slightly more predictive power. It seems that the quality of life and severity of menopausal symptoms may be improved, particularly with regard to sexual symptoms, by following an anti-inflammatory diet.
Detection of attacks in the Internet of Things with the feature selection approach based on the whale optimization algorithm and learning by majority voting
Authors: Aliabadi Mohammad Sharifi , Jalalian Afsaneh 
Published: January 2023

Abstract
Penetration into the Internet of Things network is a challenge in the security of new-generation networks and smart cities. In most cases, malware is distributed in the Internet of Things and smart objects are infected by malware. Objects infected with malware or viruses, which are called botnets, perform attacks such as DDoS against network services. DDoS attacks make network services inaccessible to users. A suitable approach to detect attacks based on malware and botnet is to use intelligent and distributed intrusion detection systems in the Internet of Things and smart cities. In other research, a centralized architecture and deep learning and machine learning method have been used to design intrusion detection systems. Centralized approaches have limited ability to process large volumes of traffic and are vulnerable to DDoS attacks. In this paper, a distributed intrusion detection system is designed with two stages dimensionality reduction and classification. In the first stage, a new and improved version of the whale optimization algorithm(WOA) has been used to select features and reduce traffic dimensions in fog nodes. In the second stage, each fog node performs the classification of the important features of the network traffic by voting and combined learning. The fog nodes share the IP address of the attacking nodes with the detection of the attacking node. Experiments showed that the improved WOA algorithm has less error in calculating the optimal solution than the optimization algorithm of the WOA algorithm. Reducing the feature selection objective function in the proposed method shows that the WOA algorithm is finding optimal features for intrusion detection and reducing the intrusion detection error. The advantage of the proposed intrusion detection system is to deal with DDoS attacks and cooperation between fog nodes to share blacklists. Tests showed that the proposed method in detecting network intrusion without feature selection has accuracy, sensitivity, and precision of 98.21%, 98.09%, and 97.88%. The proposed method with feature selection has accuracy, sensitivity, and precision of 99.39%, 99.31%, and 99.28%. The accuracy and precision of the proposed method in network intrusion detection are higher than the gray wolf algorithm, genetics and support vector machine, the binary gray wolf algorithm, and the hybridized GWO and GA algorithm. The proposed method is more accurate in intrusion detection than the GWO + PSO and firefly algorithms.
eEF2 improves dense connective tissue repair and healing outcome by regulating cellular death, autophagy, apoptosis, proliferation and migration
Authors: Chen Junyu , Wang Jin , Wu Xinjie , Simon Nils , Svensson Camilla I , Yuan Juan , Hart David A , Ahmed Aisha S , Ackermann Paul W 
Published: January 2023

Abstract
Outcomes following human dense connective tissue (DCT) repair are often variable and suboptimal, resulting in compromised function and development of chronic painful degenerative diseases. Moreover, biomarkers and mechanisms that guide good clinical outcomes after DCT injuries are mostly unknown. Here, we characterize the proteomic landscape of DCT repair following human tendon rupture and its association with long-term patient-reported outcome. Moreover, the regulatory mechanisms of relevant biomarkers were assessed partly by gene silencing experiments. A Mass-Spectrometry based proteomic approach quantified a large number (769) of proteins, including 51 differentially expressed proteins among 20 good versus 20 poor outcome patients. A novel biomarker, elongation factor-2 (eEF2) was identified as being strongly prognostic of the 1-year clinical outcome. Further bioinformatic and experimental investigation revealed that eEF2 positively regulated autophagy, cell proliferation and migration, as well as reduced cell death and apoptosis, leading to improved DCT repair and outcomes. Findings of eEF2 as novel prognostic biomarker could pave the way for new targeted treatments to improve healing outcomes after DCT injuries.
Analysis of the association of NPHS2 and ACTN4 genes polymorphism with nephrotic syndrome in Egyptian children
Authors: El-Khawaga Omali , Al-Haggar Mohammad , ElSaid Afaf M. , al-azzawy Mohamed 
Published: January 2023

Abstract
Background
One of the most common kidney illnesses in developing countries is pediatric nephrotic syndrome (PNS), which is frequently associated with dyslipidemia and edema. The rapid discovery of genes related to NS has aided in the understanding of the molecular mechanics of glomerular filtration. The goal of this study is to determine the relationship between NPHS2 and ACTN4 in PNS youngsters.
Methods
A study with 100 NS children and 100 healthy matched volunteers was conducted. Genomic DNA was extracted from peripheral blood. Single-nucleotide polymorphisms were genotyped using ARMS-PCR.
Results
a substantial decline in the level of albumin was found in NS cases (p < 0.001) Further on, a significantly difference in T.C and TG level between healthy and NS patient. Molecular study showed a highly significant difference of NS patients from controls regarding NPHS2 rs3829795 polymorphic genotypes as the GA heterozygous genotype shows highly significant difference from controls (P < 0.001) as well as GA + AA genotypes (P < 0.001) in comparison with GG genotype. Regarding rs2274625, The GA heterozygous genotype showed no statistically significant difference between genotypes and alleles with NS (p = 0.246). Association of AG haplotype NPHS2 rs3829795-rs2274625 haplotypes found a significant association with the risk of developing NS (p = 0.008). Concerning the ACTN4 rs121908415 SNP, there was no link between this mutation and NS children.
Conclusion
The Correlation of AG haplotype NPHS2 rs3829795-rs2274625 haplotypes identified a strong association with the likelihood of getting NS, according to our findings. There was no connection found between the ACTN4 rs121908415 SNP and NS children.
The surgical management of intrathoracic pseudomyxoma peritonei
Authors: Ren Dewang , Wang Zhiyuan , Miao Libin , Lu Weiqiang , Ma Runyang , Dou Xuejun 
Published: January 2023

Abstract
Backgrounds: To explore the clinical features, diagnosis, treatment, and prognosis of intrathoracic pseudomyxoma peritonei.
Methods: A retrospective analysis of the clinical findings pertaining to five intrathoracic pseudomyxoma peritonei patients that underwent surgical treatment at the Aerospace Center Hospital between March 2013 and May 2021 was conducted. All patients underwent thoracic cytoreductive surgery to resect all visible intrathoracic mucinous lesions, followed by regular follow-up to detect postoperative outcomes.
Results: Four patients exhibited evidence of direct extension into the pleural cavity, and three underwent parietal/visceral pleurectomy to remove the mucinous tissue from the thoracic cavity to the greatest degree possible. One patient underwent the resection of disseminated pleural and lung lesions followed by hyperthermic intrathoracic chemotherapy (HITOC). One patient exhibited pulmonary metastases and underwent lobectomy. Macroscopic tumor resection was performed for all patients. Postoperative histopathology results from all five patients revealed a diagnosis of low-grade peritoneal pseudomyxoma arising from the appendix. One patient developed incomplete intestinal obstruction on day 5 post-surgery and was discharged following successful treatment. None of the included patients experienced operative mortality or serious postoperative complications. Patients were monitored for a mean follow-up interval of 22 months, and exhibited 1- and 3-year survival rates of 100% (5/5) and 40% (2/5), respectively.
Conclusion: Intrathoracic pseudomyxoma peritonei is a rare clinical disease associated with a poor prognosis that primarily results following injury to the diaphragm during the surgical treatment of pseudomyxoma peritonei. Cytoreductive surgery to treat thoracic tumors in combination with HITOC can alleviate the symptoms of this condition and can contribute to better prognostic outcomes. However, it is important to remain attentive to the potential for perioperative complications.
Effect of preoperative dynamic cervical sagittal alignment on the loss of cervical lordosis after laminoplasty
Authors: Liu Chengxin , Shi Bin , Wang Wei , Li Xiangyu , Lu Shibao 
Published: January 2023

Abstract
Purpose Cervical laminoplasty (CLP) is a developed surgical procedure for the treatment of cervical spondylotic myelopathy (CSM), but only a few of those studies focus on preoperative dynamic cervical sagittal alignment and the study of different degrees of loss of cervical lordosis (LCL) is lacking. This study aimed to analyze patients who underwent CLP to investigate the effect of cervical extension and flexion function on different degrees of LCL.
Methods This was a retrospective study of the patients who underwent CLP between January 2019 and December 2020. The cervical lordosis (CL), T1 slope (T1S), cervical sagittal vertical axis (cSVA), CL in flexion (Flex CL), CL in extension (Ext CL), cervical spine range of motion (ROM), cervical spine range of flexion (Flex ROM) and extension (Ext ROM) were measured. The extension ratio (EXR) was defined as 100 × Ext ROM/ROM. LCL was defined as preoperative CL - postoperative CL. Patients were classified into the following three groups according to the LCL: stability group: (LCL ≤ 5°); mild loss group (5° < LCL ≤ 10°); and severe loss group (LCL > 10°). The Japanese Orthopedic Association (JOA) score was used.
Results Seventy-nine patients were enrolled (mean age 62.92 years; 51 men, 28 women) in the study. Among the three groups, cervical extension Ext ROM was the best in the stability group. Compared with the stability group, Flex ROM was significantly higher and the extension ratio (EXR) was significantly lower in the severe loss group. Compared with the severe loss group, JOA recovery rates were better in the stability group. Receiver-operating characteristic curve (ROC) analysis to predict LCL > 10° (area under the curve = 0.808, p < 0.001). The cutoff value for EXR was 16.80%, with sensitivity and specificity of 72.5% and 82.4%, respectively.
Conclusion CLP should be carefully considered for patients with a preoperative low Ext ROM and high Flex ROM, as a significant kyphotic change is likely to develop after surgery. EXR is a useful and simple index to predict significant kyphotic changes.
Chemically and Electronically Active Metal Ions on InAs Quantum Dots for Infrared Detectors
Authors: Oh Nuri , Kim Seongchan , Yeon Sooyeon , Lee Minwoo , Jin Junyoung , Shin Seungki , Gwak Namyoung , Jeong Inyoung , Jang Hyunwoo , Hwang Gyu Weon 
Published: January 2023

AbstractColloidal InAs quantum dots (QDs) are emerging candidates for NIR-SWIR optoelectronic applications because of their excellent electrical and optical properties. However, the synthesis of InAs QDs, which demands a strongly reducing atmosphere or highly reactive precursors, is difficult because of their strong covalent bonding nature and lack of group 15 precursors. While the co-reduction method with commercially available arsenic precursors enables the facile synthesis of InAs QDs, it causes a broad size distribution, requiring a subsequent size-selection process. In this study, we introduce zinc metal ions in the form of a coordination complex during the co-reduction reaction of indium and arsenic precursors. Zn ions can chemically passivate the surface of InAs QDs, allowing the promotion of size focusing and removal of surface defects. When the InAs QDs are integrated into infrared photodiodes as IR absorbers, the surface-attached Zn ions can electrically modulate the energy level and carrier concentration. The infrared photodiodes with InAs:Zn QD layers exhibit two orders of magnitude lower dark current and about twice faster photo-response than those using bare InAs QDs.
Inhibitive effect of new nitrogen and sulfur containing azole derivatives on mild steel corrosion in HCl solution: Electrochemical, SEM and AFM studies
Authors: Gikani Zohreh , Khanmohammadi Hamid , Hassannejad Hossein 
Published: January 2023

Abstract
Twoazole-based Schiff bases, namely 2-(((1H-1,2,4-triazol-3-yl)imino)methyl)-4-bromophenol, TIB, and 4-Bromo-2-((thiazol-2-ylimino)methyl)phenol, BTP, were synthesized and applied as corrosion inhibitors for mild steel, MS, in 0.5 M hydrochloric acid medium based on investigations with weight loss, potentiodynamic polarization, and electrochemical impedance measurements. Electrochemical impedance study showed that in the presence of TIB and BTPthe corrosion of MS in acidic medium was reduced significantly through a charge transfer mechanism. Tafel polarization revealed that the TIB and BTP behaved as mixed-type inhibitors, predominantly of cathodic type. The MS surface has been blocked by inhibition action of TIB and BTP molecules following Langmuir adsorption isotherm. The formed protective layer on MS surface was verified using scanning electron microscopy (SEM) and X-ray spectroscopy (EDX) techniques. Furthermore, atomic force microscopic (AFM) study revealed that the current inhibitors increase the surface smoothness of AFM micrographs by adsorbing on the metallic surface. Experimental results declared that the optimum concentration of TIB and BTP for coverage of MS surface are 600 µM and 400 µM, respectively. In addition, TIB is a more effective corrosion inhibitor than BTPfor MS in 0.5 M HCl medium. Furthermore, atomic force microscopic (AFM) study revealed that the current inhibitors increase the surface smoothness of AFM micrographs by adsorbing on the metallic surface.
Relaxation dynamics of water in the vicinity of cellulose nanocrystals
Authors: Chae Inseok , Paniagua-Guerra Luis E. , Pitcher Mica L. , Koshani Roya , Yuan Mengxue , Lin Yen-Ting , Lee Jongcheol , Perini Steven E. , Sheikhi Amir , Ramos-Alvarado Bladimir , Lanagan Michael T. , Kim Seong H. 
Published: January 2023

Abstract
Water molecules near cellulose nanocrystals (CNCs; produced via sulfuric acid-catalyzed hydrolysis) are believed to relax slower than those in the bulk liquid, which may result in unique properties of CNC aqueous dispersions. This study analyzed the polarization behavior of water molecules in CNC aqueous dispersions and other reference samples using a dielectric relaxation spectroscopy (DRS) technique in the microwave frequency range (200 MHz – 20 GHz). As the CNC concentration increases, two slow relaxation components become prominent. The comparison with DRS data of aqueous dispersions of nanoporous silica, polyvinyl alcohol (PVA), and hairy CNCs with amorphous chains in both ends suggested that these slow relaxation modes of water near CNC surfaces cannot be attributed to direct hydrogen bonding interactions with the hydroxyl (OH) groups exposed and immobilized at the solid surface. Instead, they are rather similar to the water molecules interacting with OH groups attached to flexible polymer chains. Molecular dynamics (MD) simulations of the polarization behavior of water near the (110) facet of cellulose Ib crystals confirmed that the interactions of water molecules with the cellulose crystal surface do not cause slower relaxations in the frequency range studied via the DRS. These results indicated that the CNC surface cannot be depicted with the crystallographic facets of cellulose Iβ; instead, it resembles a polymer-brush surface on which the short glucan residues or fragments of the strong acid-catalyzed hydrolysis process are swollen and extended into the aqueous phase.