bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of laparoscopic complete mesocolic excision combined with immunotherapy and its impact on immune function and tumor markers in elderly patients with colon cancer
Authors: Zhang Tao , Lin Qian , Liu Zhi , Yang Hua 
Published: July 2023

Objective: To determine the effect of laparoscopic complete mesocolic excision combined with immunotherapy and its impact on immune function and tumor markers in elderly patients with colon cancer.
Methods: This is a clinical comparative study. Eighty elderly patients with colon cancer hospitalized in the No.2 Hospital of Baoding from May 2020 to May 2022 were randomly divided into two groups, with 40 cases in each group. Patients in the study group received laparoscopic complete mesocolic resection combined with ubenimex orally. While patients in the control group received routine open surgery. The surgical indexes, surgical complications, and the changes of immune molecules and tumor markers before and after treatment were compared between the two groups.
Results: The amount of intraoperative bleeding, retention time of drainage tube and postoperative length of stay in the hospital in the study group were significantly better than those in the control group (p=0.000). The incision length of the study group was significantly shorter than that of the control group, the number of lymph nodes removed during the operation was significantly higher than that of the control group, and the incidence of surgical complications was significantly lower than that of the control group (p<0.05). After treatment, the levels of immune molecules in the study group were remarkably higher than those in the control group (p<0.05), while the levels of tumor markers were much lower than those in the latter group (p=0.000).
Conclusion: Laparoscopic complete mesocolic excision combined with immunotherapy exhibits a superior therapeutic effect to traditional open surgery in elderly patients with colon cancer, and is worthy of clinical promotion.
doi: https://doi.org/10.12669/pjms.39.5.7090
How to cite this: Zhang T, Lin Q, Liu Z, Yang H. Effect of laparoscopic complete mesocolic excision combined with immunotherapy and its impact on immune function and tumor markers in elderly patients with colon cancer. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7090
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Exploring the value of early laboratory indicators combined with pancreatitis activity scoring system in assessing the severity and prognosis of acute pancreatitis
Authors: Xu Fang , Hu Xin , Li Shu-ling 
Published: July 2023

Objective: To investigate the value of early laboratory indicators combined with the pancreatitis activity scoring system in assessing the severity and prognosis of acute pancreatitis (AP).
Methods: This is a retrospective study. A total of 160 patients with AP admitted to the Affiliated Hospital of Hebei University from February 2021 to February 2023 were enrolled and classified into three categories: mild acute pancreatitis (MAP), moderate severe acute pancreatitis (MSAP), and severe acute pancreatitis (SAP), with 80 cases with MAP and MSAP as the control group and 80 cases with SAP as the experimental group. The differences of inflammatory markers, blood routine, biochemical markers, coagulation markers and PASS score within 24 hours after admission were compared between the two groups, and independent risk factors for predicting AP severity were analyzed. Moreover, the diagnostic efficacy and prognostic value of independent risk factors were evaluated.
Results: The PASS score as well as CRP, PCT, IL-6, WBC, N, AST, DD and PT were higher in the experimental group than in the control group. Logistic regression analysis suggested that PASS, IL-6, PCT and WBC were independent risk factors for predicting severity of AP. In addition, PASS had the highest diagnostic efficacy.
Conclusion: Early elevation of PASS, IL-6, PCT and WBC in patients suffering from AP is of great significance in predicting SAP. PASS score combined with IL-6, PCT and WBC has important value in evaluating the severity and prognosis of AP.
doi: https://doi.org/10.12669/pjms.39.5.7543
How to cite this: Xu F, Hu X, Li S. Exploring the value of early laboratory indicators combined with pancreatitis activity scoring system in assessing the severity and prognosis of acute pancreatitis. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7543
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Vocal health of parents of children with hearing assistive devices
Authors: Qayyum Uzma , Mumtaz Nazia , Saqulain Ghulam 
Published: July 2023

Background & Objectives: VH (Vocal health) is the need of the hour. VH of parents of children with hearing assistive devices (HAD) reveals a literature gap, during the habilitation process of their children. To explore the vocal health of parents of children with hearing assistive devices.
Methods: This cross-sectional study was conducted at Riphah International University from September to December 2021. Study recruited N=384 parents of Hearing Impaired children (HIC) using HAD for at least two years, of both genders and aged 2-9 years using convenience sampling. Voice-related quality of life (V-RQOL), and vocal health Index (VHI) -10 were used for data collection. Data was analyzed on SPSS Version 25. Descriptive statistics, Anova and t-test were utilized to see difference between means of groups. P<0.05 shows significant-results.
Results: Parents of children using hearing assistive devices had excellent V-RQOL score in 350(91.14%) parents. There was no significant difference in V=RQOL as regards type of hearing assistive device use (p=0.102), laterality of device use (p=0.918) and degree of hearing loss (p=0.143). However, type of hearing loss revealed significant difference (p=0.021). Also VHI score revealed significantly (p=0.008) lower means in parents of children with cochlear implants.
Conclusion: Current study concludes that the parents raising hearing impaired children with hearing assistive devices, possess good vocal health as determined by VHI and V-RQOL scores with only a very small number of parents reporting vocal symptoms.
doi: https://doi.org/10.12669/pjms.39.5.7570
How to cite this: Qayyum U, Mumtaz N, Saqulain G. Vocal health of parents of children with hearing assistive devices. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7570
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Surgical treatment of pelvic organ prolapse using colpocleisis: A case series
Authors: Elbiss Hassan , Al-Baghdadi Omaema 
Published: July 2023

Objective: Pelvic organ prolapse (POP) is a common condition. With increasing lifespan and emphasis on quality of life worldwide, older women with POP may prefer surgical treatment, including colpocleisis. We reviewed the outcome of POP in a case series of colpocleisis.
Methods: This study was conducted between 2006 and 2011. Patients had confirmed POP on examination and underwent partial and total colpocleisis. We compared patients’ demographic characteristics, POP severity and surgical outcomes.
Results: In total, 55 patients were included. The patients were aged 78.9 + 6.7 years and had body mass index (BMI) of 26.9 ± 4.2. Among the total, 44 (80%) and 11 patients (20%) underwent partial and total colpocleisis respectively. Patients undergoing partial colpocleisis had procidentia less often than those undergoing total colpocleisis (18% v 64%, p=0.01). Mean blood loss and operative time were 157.6 ml ± 119.0 and 65.1 ± 20.3 minutes respectively. Partial colpocleisis had less blood loss (mean 135.7 v 227.2 ml, p=0.02) and shorter operative time (mean 62.6 v 75.0 min, p=0.18).
Conclusion: Partial compared to total colpocleisis was associated with shorter operative time and less blood loss. Colpocleisis is a suitable surgical treatment for POP in elderly women who do not wish to preserve the vagina for sexual intercourse.
doi: https://doi.org/10.12669/pjms.39.5.7600
How to cite this: Elbiss HM, Al-Baghdadi O. Surgical treatment of pelvic organ prolapse using colpocleisis: A case series. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7600
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comparison of percutaneous balloon compression and microvascular decompression in the treatment of trigeminal neuralgia
Authors: Li Zhenyong , Xie Zhuqing , Tang Guoqiang , Jin Shihui 
Published: July 2023

Objective: To compare the effect of percutaneous balloon compression (PBC) and microvascular decompression (MVD) in the treatment of trigeminal neuralgia (TN).
Methods: Data of 98 patients with TN, admitted to Chenzhou First People’s Hospital from May 2020 to May 2022, were retrospectively collected. Patients were divided into two groups based on the surgical method. A total of 53 patients treated with PBC comprised the PBC-group and 45 patients treated with MVD comprised the MVD-group. The immediate pain relief, long-term efficacy, surgical complications, and masticatory muscle strength of the two groups were compared and analyzed.
Results: There was no significant difference in the immediate pain relief and long-term e efficacy, between the two groups (P>0.05). Complication rate in the PBC-group was significantly lower than that in the MVD-group (3.77% vs 17.78%, P<0.05). Medical records within 14 days after the operation showed that the incidence of facial numbness and masticatory muscle weakness in the PBC-group were 37.74% and 28.30% respectively, significantly higher than those in MVD-group (4.44% and 2.22%) (P<0.05). These symptoms gradually improved three months after the surgery, and were almost completely resolved after six months.
Conclusions: Compared with MVD, PBC has the same effect in the treatment of TN. PBC is a minimally invasive, safe, and effective method with a low complication rate. Although masticatory muscle strength is slightly impacted by PBC, it gradually recovers within six months after the operation.
doi: https://doi.org/10.12669/pjms.39.5.8049
How to cite this: Li Z, Xie Z, Tang G, Jin S. Comparison of percutaneous balloon compression and microvascular decompression in the treatment of trigeminal neuralgia. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.8049
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Classifying invasive lobular carcinoma as special type breast cancer may be reducing its treatment success: A comparison of survival among invasive lobular carcinoma, invasive ductal carcinoma, and no-lobular special type breast cancer
Authors: Cosar Rusen , Sut Necdet , Topaloglu Sernaz , Tastekin Ebru , Nurlu Dilek , Ozler Talar , Şenödeyici Eylül , Dedeli Melisa , Chousein Mert , Cicin Irfan 
Published: July 2023

Purpose
The literature contains different information about the prognosis of invasive lobular carcinoma of breast cancer (BC). We aimed to address the inconsistency by comparatively examining the clinical features and prognosis of invasive lobular carcinoma patients in our university and to report our experience by dividing our patients into various subgroups.

Patients and methods
Records of patients with BC admitted to Trakya University School of Medicine Department of Oncology between July 1999 and December 2021 were reviewed. The patients were divided into three groups (No-Special Type BC, Invasive Lobular Special Type BC, No-Lobular Special Type BC). Patient characteristics, treatment methods and oncological results are presented. Survival curves were generated using the Kaplan–Meier method. Statistical significance of survival among the selected variables was compared by using the log-rank test.

Results
The patients in our study consisted of 2142 female and 15 male BC patients. There were 1814 patients with No-Special Type BC, 193 patients with Invasive Lobular Special Type BC, and 150 patients with No-Lobular Special Type BC. The duration of disease-free survival (DFS) was 226.5 months for the No-Special Type BC group, 216.7 months for the No-Lobular Special Type BC group, and 197.2 months for the Invasive Lobular Special Type BC group, whereas the duration of overall survival (OS) was 233.2 months for the No-Special Type BC group, 227.9 for the No-Lobular Special Type BC group, and 209.8 for the Invasive Lobular Special Type BC group. The duration of both DFS and OS was the lowest in the Invasive Lobular Special Type BC group. Multivariate factors that were significant risk factors for OS were Invasive Lobular Special Type BC histopathology (p = .045), T stage, N stage, stage, skin infiltration, positive surgical margins, high histological grade, and mitotic index. Modified radical mastectomy, chemotherapy, radiotherapy and use of tamoxifen and aromatase inhibitors for more than 5 years were significant protective factors for overall survival.

Conclusion
The histopathological subgroup with the worst prognosis in our study was Invasive Lobular Special Type BC. Duration of DFS and OS were significantly shorter in Invasive Lobular Special Type BC than No-Lobular Special Type BC group. The classification of Invasive Lobular BC under the title of Special Type BC should be reconsidered and a more accurate treatment and follow-up process may be required.
How informed is informed consent?—Evaluating the quality of informed consent among surgical patients in a tertiary care hospital in Nepal
Authors: Basukala Sunil , Shrestha Oshan , Thapa Niranjan , Karki Sagun , Pandit Ayushma , Thapa Bikash Bikram , Thapa Anup 
Published: July 2023

Background
Informed consent-taking is a part of clinical practice that has ethical and legal aspects attached to it. This protects the autonomy of the patients by providing complete information regarding the rationale, modality, potential risks, benefits, and alternatives of the planned procedure to the patients. This enables the patients to make the right decision for themselves and their care. This study aims to find out if the informed consent-taking process has ensured the active participation of the patients or the next of kin in the decision-making.

Materials and methods
This is a prospective cross-sectional study conducted in a military healthcare institution among patients undergoing major surgical procedures from July 2022 to October 2022. Ethical clearance was obtained before the commencement of this study. A structured questionnaire was prepared, and the collected data was refined in Excel and imported into SPSS for analysis.

Results
A total of 350 individuals of mean age 47.95 ± 16.057 years were part of this study. The majority of the respondents were married, literate, and family by beneficiary category. All of the respondents received and signed the consent form. About 77% of the respondents read it completely, and 95.4% of them reported that it was understandable. The majority of the patients did not know who was going to perform the surgery, the alternatives to the planned treatment, the benefits of the surgery, or the outcome of non-treatment. On the patient satisfaction scale, 16.28% of the participants agreed that they were satisfied with the informed consent-taking process.

Conclusion
Deficiencies in the informed consent-taking process were the lack of dissemination of adequate information on the nature, duration, pros and cons, post-operative state, and alternative of the planned procedure. A well-structured format of the consent form that is specific to a particular procedure should be adopted, and various alternatives to it must be disseminated to the patient or the next of kin to improve the quality of the informed consent-taking process.
Prevalence of cardiovascular risk factors among Asian migrant workers in South Korea
Authors: Bhandari Pratibha 
Published: July 2023

Background
The burden of non-communicable diseases is rapidly increasing among young adults in middle- and low-income countries. Asian migrant workers continue to be a significant contributor to South Korea’s economy; however, their cardiovascular health is neglected. We explored the prevalence of cardiovascular risk factors among Asian migrant workers in South Korea.

Methods
Cross-sectional survey, anthropometric measurements, blood pressure measurements, and biochemical tests including triglyceride, high-density lipoprotein, low-density lipoprotein, total cholesterol, fasting blood sugar, HbA1c, and C-reactive protein levels were conducted in 141 Asian migrant workers in South Korea.

Results
The mean age of the participants was 31.3 (5.6) years. Of the participants, 14.8% were current smokers, and 47.5% consumed alcohol. The prevalence of overweight/obesity was 32.4%. The prevalence of hypertension and dyslipidemia were 51.2% and 64.6%, respectively. Of the participants, 98.5% had an increased waist circumference; elevated HbA1C and C-reactive protein was seen in 20.9% and 4.3%, respectively. The prevalence of metabolic syndrome was 5.5%. Clustering of two or more risk factors was seen in 45% of the participants. Factors associated with a high risk of cardiovascular diseases (clustering of two or more risk factors) were age (odds ratio 1.16, p < 0.01) and smoking (4.98, p < 0.05).

Conclusion
The prevalence of cardiovascular risk factors was alarmingly high among Asian migrant workers employed in South Korea. Efforts to mitigate and eliminate those risk factors are urgently required.
Paleografia e ciência da informação
Authors: Silva Carlos Guardado da , Faben Alexandre 
Published: July 2023

Este estudo procura analisar e refletir acerca do diálogo intercientífico entre a Paleografia e a Ciência da Informação. Para tal, segue uma abordagem de natureza qualitativa, suportada pelo método da Investigação Documental, quer para a revisão da literatura, quer para a pesquisa e análise da informação, de modo a aferir a existência desse diálogo em estudos no âmbito da Ciência da Informação, bem como na oferta formativa nos curricula dos cursos de Ciência da Informação, em Portugal (universidades de Coimbra, Lisboa e Porto), e de 16 cursos de graduação em Arquivologia, no Brasil.
A identificação, a organização e representação da informação relativa aos documentos antigos, pelo arquivista, pelo bibliotecário ou pelo museólogo, exigem o conhecimento dos elementos constitutivos da escrita, a interpretação e a leitura dos documentos, isto é, formação em Paleografia. Hoje, concretiza-se em estudos no âmbito da Ciência da Informação, em que a Paleografia marca presença nos planos curriculares de Ciência da Informação, em Portugal, como opção, e em 14 dos 16 cursos de Arquivologia no Brasil, sendo a sua frequência obrigatória em 12 cursos de graduação.
Sociotechnical infrastructuring for digital participation in rural development: A survey of public administrators in Germany
Authors: Stein Veronika , Pentzold Christian , Peter Sarah , Sterly Simone 
Published: July 2023

Abstract
The “smart village” flourishes – at least in policy papers that envision the revitalization of rural areas through the civic deployment of networked media and telecommunications. Yet, while such aspirations are widespread, little is known about the views of those tasked with supervising and supporting digitally driven public participation for rural progress. To address the lack of insight into what these intermediary administrators conceive as catalysts and challenges for the realization of smart village conceptions, we surveyed representatives of regions in Germany who oversee rural development schemes, most notably within the European LEADER framework. For these key actors, digital participation does not mainly hinge on broadband access and IT availability. Instead, they emphasize the importance of human and administrative resources as well as multi-actor collaboration, which we discuss in terms of digital readiness, digital willingness, and digital activity. Building the smart village, we conclude, seems not so much a matter of technological infrastructure, but rather of sociotechnical infrastructuring.
Conspiracy Theories in the US: Who Believes in Them?
Authors: Stockemer Daniel 
Published: July 2023

Abstract
Conspiracy theories have become an increasingly important part of the political realm especially in the United States. More than 30 % of citizens either strongly or somewhat believe in QAnon, the Birther or the Truther conspiracy to name a few of these theories. In this article, I provide an overview of conspiracy theory beliefs and evaluate the factors that make people more likely to believe in such theories. With the help of an original survey comprising 1000 residents in the US, I detect that there is not necessarily a conspirational mindset. While low education, a right-wing ideology seem to increase beliefs in conspiracy theories throughout the board, the effects of other indicators including populist attitudes, low self-esteem and age tend differ based on the conspiracy theory under investigation.
Savanorių, kaip mentorių, veikla teikiant pagalbą vaikams, dalyvaujantiems “Big Brothers / Big Sisters” programoje
Authors: Klanienė Ilona , Glybina Alina , Šmitienė Gražina , Lengvinas Donatas 
Published: July 2023

Šiuolaikinėje visuomenėje vaikai patenka į krizines situacijas, susiduria su šeimos problemomis, jiems kyla mokymosi sunkumų, visa tai veikia jų socialinę ir emocinę brandą. Vaikų ugdymu ir apsauga rūpinasi daug įvairių organizacijų, vis dėlto, be institucinės globos, jiems ypač svarbi individuali suaugusiojo parama ir socialinis palaikymas, tad kuriamos įvairios socialinės pedagoginės pagalbos programos, kurios rengia suaugusius savanorius, kurie pasiryžta tapti vaikų mentoriais. Straipsnyje analizuojamos savanorių, dalyvaujančių programoje “Big Brothers / Big Sisters” (BB / BS), veiklos galimybės teikiant pagalbą vaikams. Atliktas kokybinis tyrimas, kuriame dalyvavo trys grupės informantų: vaikai, tėvai (globėjai), savanoriai (16 dalyvių). Kokybinio tyrimo rezultatai atskleidė, kad visų trijų grupių informantai įžvelgia neabejotiną šios programos naudą vaikams. Savanoriai šioje programoje ne tik tampa vedliais sprendžiant vaikui iškylančias gyvenimiškas problemas „čia ir dabar“, bet ir sudaro geresnes sąlygas jų saviraiškai, padeda tobulinti vaikų bendravimo įgūdžius, skatina labiau pasitikėti savimi. Tyrimo rezultatai atskleidė, kad šioje programoje dirbantiems savanoriams ypač svarbi profesionali programos koordinatoriaus pagalba, dalijimasis patirtimi su kitais savanoriais ir jos reflektavimas.