bluuebunny/crossref_metadata_2025_split huggingface dataset:
FINGER PAINTING DALAM MENSTIMULUS PERKEMBANGAN MOTORIK HALUS ANAK USIA DINI
Authors: Jumriatin Jumriatin , Anhusadar Laode 
Published: May 2023

Penelitian ini bertujuan untuk (1) mengetahui gambaran perkembangan motorik halus anak pada kelompok B di TK Al-Aqsho, (2) pelaksanaan dari kegiatan Finger Painting dalam pengembangan motorik halus anak pada kelompok B di TK Al-Aqsho Desa Lamomea Kecematan Konda Kabupaten Konawe Selatan. penelitian ini dilaksanakan melalui pendekatan tindakan kelas (PTK) dengan dua siklus model Kemmis dan Mc Taggart yang yang memiliki empat tahapan yakni perencanaan, tindakan, observasi, dan refleksi. Setiap siklus dilakukan dengan tiga kali pertemuan. Tehnik pengumpulan data yang digunakan adalah observasi, dokumentasi dan penilaian. Hasil penelitian menunjukkan bahwa Finger Painting dapat meningkatkan perekmbangan motorik halus anak kelas B di TK Al-Aqsho Desa Lamomea Kecematan Konda Kabupaten Konawe Selatan. Pelaksanaan kegiatan Finger Painting dalam pengembangan motorik halus anak pada kelompok B2 di TK Al-Aqsho Pada siklus 1 menunjukkan kemampuan anak dominan berada pada kriteria ketuntasan 62,05% atau berada pada kategori cukup. Pada siklus 2 menunjukkan kemampuan anak berada pada rentang penilaian berkembang sesuai harapan dengan kriteria ketuntasan sebanyak 75% atau berada dalam kategori baik kemampuan motorik halusnya pada indikator anak dapat menggunting sesuai pola ketuntasannya 75%, indikator kerapian dalam mencetak gambar 75%, indikator meniru bentuk 62,5%, dan mencetak sesuai gagasan ketuntasan 75%.
Prognostic value of macrophage vasculiform mimicry in the evaluation of uveal melanoma progression
Authors: Shamanova A. Y. , Kazachkov E. L. , Panova I. E. , Saevets V. V. , Yarina L. V. , Shamaeva T. N. , Vlasova V. M. 
Published: May 2023

Introduction Uveal melanoma (UM) is a malignant neoplasm of the vascular tract of the eye, prone to hematogenous metastasis, regardless of the type of treatment performed. Prediction and probability of UM metastasis is one of the main tasks of onco-ophthalmology. We decribed an alternative method of tumor blood supply due to the process of vasculo-like mimicry (VM) with the formation of pseudovascular structures of tumor cells is described. At the same time, the participation of the microenvironment in the processes of VM and metastasis is currently debatable and relevant.Purpose of the work was to evaluate the prognostic role of macrophage vasculiform mimicry in the progression of chorioid melanoma based on the histological and immunohistochemical characteristics of surgical material.Materials and methods The surgical material of choroidal melanoma after enucleation for the period 2013-2018 was studied. Histological, histochemical (PAS reaction) and immunohistochemical studies were carried out using markers CD68 (macrophages), CD 34, CD31, D2-40 for the purpose of qualitative and quantitative assessment of macrophages in the stroma of tumors, large vessels and pseudovessels in the tumor.Results The ability of macrophages to form vasculo-like spaces in choroidal melanoma has been discovered and described. In growth with macrometastases, more phage representatives are recorded than in tissue samples of non-metastasizing melanoma. the volume of the macroscopic mass of the ulcer and the growth rate of phages were registered as the inverse average in terms of the strength of the correlation. In group studies with metastases, an increase in the volume of pseudovascular volumes and the number of phages is recorded.Discussion The macrophage microenvironment in a tumor can play a dual role: antitumor and protumor. The ability of macrophages for VM in UM has been described. The results of our macrostudy confirm the protumor activity of phages and their important role in tumor metastasis.Conclusion In-depth study of the ways of pseudovascular space formation not only by the cells of the tumor itself, but also by its microenvironment, helps to open new directions in the study of predictors of UM metastasis and outline approaches to the development of new directions of anti-tumortherapy.
Cell renewal index in the differential diagnosis of atypical small acinar proliferation and adenocarcinoma of the prostate
Authors: Dub A. A. 
Published: May 2023

Introduction Singling out such diagnostic category as atypical small acinar proliferation of the prostate (ASAP) determines the necessity of forming additional approaches to differential morphological diagnosis in order to determine adenocarcinoma in time. Cell renewal index (CRI) is actively used to study proliferation and apoptosis in the epithelial cells of hormone-dependent glands, but in prostate pathology this criterion has not been studied.The aim of the study was to characterize the cell renewal index in atypical small acinar proliferation and prostate adenocarcinoma of different degrees of differentiation in order to optimize differential diagnosis.Materials and methods We studied 720 prostate biopsy specimens from 60 patients: Group 1 — 15 patients with ASAP; Group 2 − 15 with adenocarcinoma of high-grade of differentiation; Group 3 − 15 with moderately differentiated adenocarcinoma; Group 4 − 15 with low differentiated adenocarcinoma. We used immunohistochemical method (Ki-67, CPP32) and non-parametric statistical methods of investigation.Results The CRI in ASAP was comparable to that in highly differentiated adenocarcinoma (p=0.5). In moderately differentiated adenocarcinoma the CRI was significantly higher than in ASAP and highly differentiated adenocarcinoma (p=0.004). The greatest increase in CRI was noted in the low-differentiated adenocarcinoma group, which was higher and significantly different from the ASAP (p=0.000), highly differentiated carcinoma (p=0.003) and moderately differentiated prostatic carcinoma (p=0.000) groups.Discussion On the basis of statistical analysis the present study helped to reveal the identity of CRI parameters in ASAP and highly differentiated adenocarcinoma of the prostat, which allows to add a number of morphological criteria for transferring patients from the group of undetermined diagnosis of ASAP to the group of adenocarcinoma. There is a need for further investigation of CRI with multiparametric analysis including investigation of the expression levels of hormones involved in the regulation of cell renewal in the prostate and growth factors associated with them.Conclusion The study allowed to reveal the identity of the CRI in ASAP and highly differentiated adenocarcinoma of the prostate, which can supplement a number of morphological criteria for transferring patients from the group of undeterminate diagnosis of ASAP to the group of adenocarcinoma.
Predictive assessment of micro RNA expression level and number of nucleolar organizer regions with follicular thyroid tumor of undetermined malignant potential
Authors: Il’ina T. E. , Kazachkov E. L. , Sergijko S. V. 
Published: May 2023

Introduction This article presents the current views on follicular thyroid tumor of undetermined malignant potential (FTUMP) taking into account the principles of WHO classification. Molecular genetic study with identification of mutation of some genes as well as determination of expression level of some microRNAs are given as methods for detection of potential predictors of oncodiagnostics. It was shown that the state of nucleus organizer regions is a marker of cell proliferation rate.The aim of the investigation was to estimate prognostic significance of expression level of some microRNAs and amount of regions of the nucleus organizers in the thyroid tissue at FTUMP to objectify approaches to development of adequate surgical tactics.Materials and methods Profile, microRNA expression level by real time PCR and regions of the nucleus organizers were studied in 98 cases of FTUMP which made up 4.75% of all cases of thyroid tumors operated on during four years.Results In 29 (29.6%) cases the spectrum of microRNA typical for malignant neoplasms was registered in the tissue of the FTUMP. In the remaining 69 (70.4%) cases out of 98 observations the spectrum and the expression level of microRNA corresponded to the follicular adenoma. Statistically significant differences in the average number of AgNORs and correlation between the cell area and the number of AgNORs granules were found within the formed subgroups.Discussion Increase of the mean number of AgNORs and the ratio of the nucleus area to the number of silver nitrate granules in the 2nd subgroup in comparison with the 1st one, as well as the appearance of the type II cells testifies to the appearance of the proliferating tumor cells in a new tumor growth and can be considered as prognostic criteria of tumor malignization. These results correlate with the findings of molecular-genetic study. Conclusion The data of the literature and the results obtained by studying the profile and the expression level of a number of microRNAs, morphometric characteristics and counting of thyrocyte nucleus organizer regions may serve as additional criteria for evaluation of the proliferative activity of the follicular epithelium in thyroid neoplasms, in particular to clarify the malignancy potential. Preoperatively diagnosed conditionally malignant FTUMP will allow to justify the necessity and amount of surgical intervention, and if a complex of criteria of conditionally benign FTUMP is revealed, to stick to the waiting tactics and refuse surgical intervention.
Immunohistochemistry of bone marrow extracellular matrix in ph-negative myeloproliferative diseases
Authors: Gogoleva D. V. , Sychugov G. V. 
Published: May 2023

Introduction Evaluation of immunohistochemical expression of matrix metalloproteinases 2 and 9 (MMP2, MMP9), their inhibitors (TIMP1, TIMP2), fibroblast growth factor (FGF2), transforming growth factor beta (TGFB1) and collagen type III in the bone marrow of patients with Ph-negative myeloproliferative neoplasms (MPN) is of great importance.The aim of the study was the evaluation of expression of extracellular matrix components (MMP-2, MMP-9, TIMP1, TIMP-2, FGF2, TFGB1, Collagen III) involved in myelofibrosis progression in bone marrow trepan biopsies depending on mutational status of patients with CMPD.Materials and methods We analyzed 108 bone marrow biopsies of patients with MPN, which were divided into 3 groups: JAK2-positive (n=62), CARL-positive (n=25) and triple-negative (n=21). Whole-slide sections were immunostained using antibodies against MMP-2, MMP-9, TIMP-1, TIMP-2, FGF2, TGFB1, collagen type III and scored by ImageJ plugin software. We used Kruskal- Wallis test and Mann-Whitney U-test for comparisons of differences in medians. Spearman’s rank order correlation was calculated. Statistical significance was set at p<0,05.Results and Discussion MMP2 expression was observed in megakaryocytes. MMP9 expression was observed in neutrophils, macrophages and the bone marrow extracellular matrix (EM). TIMP1 expression was observed in the EM. TIMP-2, FGF2, TGFB1 and collagen type III expression was observed in megakaryocytes and the EM. Kruskal-Wallis test determined the differences between all 3 groups (MMP- 2 p< 0,001, MMP-9 p=0,023, TIMP-1 p< 0,001, TIMP-2 p< 0,001, FGF2 p< 0,001, TGFB1 p< 0,001, collagen type III p< 0,001). Mann-Whitney U-test determined the most differences between JAK2- and CALR-groups (MMP-2 p=0,001, MMP-9 p=0,001, TIMP-1 p=0,001, FGF2 p=0,001, TGFB1 p=0,001, collagen type III p=0,001), except TIMP-2. There was the weak and moderate positive correlation between JAK2-mutation and the immunohistochemistry expression of EM components, also the weak negative correlation between CALR-mutation and the immunohistochemistry expression of EM components.Conclusion The bone marrow immunohistochemistry expression of MMP-2, MMP-9, TIMP-1, TIMP-2, FGF2, TGFB1, collagen type III depends on driver mutations. It may be useful for understanding of fibrosis pathogenesis and prognosis estimate of Ph-negative MPN.
UPAYA PENINGKATAN PENAMBANGAN DATA MELALUI APLIKASI GUNA MENDUKUNG KEBIJAKAN STRATEGIS PEMERINTAH DIBIDANG PARIWISATA BEKERJA SAMA BAPEDA KOTA PENGKALPINANG
Authors: Yurindra Yurindra , Sarwindah Sarwindah , Marini Marini , Kori Kurniawan  , Nurwasya Nurwasya 
Published: May 2023

Kegiatan ini didasari pada tujuan dalam membantu pemerintah daerah pariwisata guna Penambangan data seperti yang kita ketahui teknologi informatika bukanlah hal baru, namun dalam penggunaannya hampir seluruh bidang menggunakkan database terintegrasi sebagai salah satu bentuk alat pengambilan keputusan yang strategis,maka dari itu kami menawarkan hasil penelitiankami untuk mengupayakan peningkatan data melalui aplikasi guna mendukung kebijakan strategi pemerintah dibidang pariwisata bekerjasama dengan BAPEDA kota pangkalpinang. Pengolahan data pengunjung hotel pada saat ini dirasa semakin dibutuhkan untuk pengolahan informasi wisatawan, terutama bila itu akan digunakan sebagai informasi untuk membuat kebijakan bagi Pemerintah daerah yang ingin memajukan sektor pariwisata di daerahnya. Pemerintah daerah harus mampu menentukan kebijakan strategis dan taktis dalam mengangkat tujuan dari sektor pariwisata yang dimaksud.Yang jadi masalah adalah bahwa tidak semua pemerintah daerah memiliki dan menyadari pentingnya data pengunjung hotel sebagai informasi penunjang bagi kemajuan sektor pariwisata didaerahnya. Untuk itu dirasa perlu membuat dan menetukan indikator berdasarkan data pengujung yang dibutuhkan sebagai alat penambangan data yang dapat digunakan sebagai basis data bagi pemerintah daerah dalam melakukan analisis terhadap pengunjung hotel. Metode penelitian menggunakan penelitian terapan karena hasil dari penelitian diharapkan akan langsung dapat digunakan untuk keperluan praktis yaitu pengembangan kebijakan dibidang pariwisata.
Critical Review of Oncologic Medical Malpractice Claims Against Orthopaedic Surgeons
Authors: Davis William , Kichena Shravya , Eckhoff Michael D. , Childs Benjamin R. , Rajani Rajiv , Wells Matthew E. , Kelly Sean P. 
Published: May 2023

Introduction:
The purpose of this study was to determine the most common allegations for malpractice litigation brought against orthopaedic surgeons for oncologic matters and the resulting verdicts.

Methods:
The Westlaw Legal research database was queried for malpractice cases filed against orthopaedic surgeons for oncologic matters in the United States after 1980. Plaintiff demographics, state of filing, allegations, and outcomes of lawsuits were recorded and reported accordingly.

Results:
A total of 36 cases met the inclusion and exclusion criteria and were subsequently included in the final analysis. The overall rate of cases filed remained consistent through the past four decades and was primarily related to a primary sarcoma diagnosis in adult women. The primary reason for litigation was failure to diagnose a primary malignant sarcoma (42%) followed by failure to diagnose unrelated carcinoma (19%). The most common states of filing were primarily located in the Northeast (47%), where a plaintiff verdict was also more commonly encountered as compared with other regions. Damages awarded averaged $1,672,500 with a range of $134, 231 to $6,250,000 and a median of $918,750.

Conclusion:
Failure to diagnose primary malignant sarcoma and unrelated carcinoma was the most common reason for oncologic litigation brought against orthopaedic surgeons. Although most of the cases ruled in favor of the defendant surgeon, it is important for orthopaedic surgeons to be aware of the potential errors that not only prevent litigation but also improve patient care.
Arthrofibrosis in Robotic Total Knee Arthroplasty: An Investigation Into How Robotic Assistance May Contribute to a Tight Knee
Authors: Ali Muzaffar , Ferguson Christopher , Singh Inderpreet , Phillips David , Sadhwani Shaan , Kahan Michael , Kamson Anthony O. , Angerett Nathan , Hallock Richard H. , Dahl Raymond , King Scott G. 
Published: May 2023

Introduction:
Arthrofibrosis after total knee arthroplasty (TKA) can lead to pain and restricted range of motion. Matching native knee kinematics is crucial in avoiding arthrofibrosis postoperatively. However, manual jig-based instruments have demonstrated variability and inaccuracy during primary TKA. Robotic-arm-assisted surgery was developed to increase the precision and accuracy of bone cuts and component alignment. In the literature, limited information on arthrofibrosis after robotic-assisted TKA (RATKA) exists. The purpose of this study was to compare the incidence of arthrofibrosis after manual TKA (mTKA) with RATKA by examining the need for manipulation under anesthesia (MUA) postoperatively and evaluating preoperative and postoperative radiographic parameters.

Methods:
A retrospective analysis of patients who underwent primary TKA from 2019 to 2021 was conducted. Rates of MUA were evaluated and perioperative radiographs were analyzed to determine posterior condylar offset ratio, Insall-Salvati Index, and posterior tibial slope (PTS) in patients who underwent mTKA versus RATKA. Range of motion was recorded for patients who required MUA.

Results:
A total of 1234 patients were included, of which 644 underwent mTKA, and 590 underwent RATKA. Thirty-seven RATKA patients compared with 12 mTKA patients required MUA postoperatively (P < 0.0001). A significant decrease in PTS postoperatively was seen in the RATKA (7.10° ± 2.4° preoperatively versus 2.46° ± 1.2° postoperatively), with a mean decrease of the tibial slope of −4.6° ± 2.5° (P < 0.0001). In patients requiring MUA, a larger decrease was seen in the RATKA group when compared with the mTKA group (mean −5.5 ± 2.0 versus −5.3 ± 0.78, P = 0.6585). No significant difference was seen in the posterior condylar offset ratio and Insall-Salvati Index in both groups.

Discussion:
When conducting RATKA, it is important to match PTS close to the native tibial slope to decrease the incidence of arthrofibrosis postoperatively, as a decrease in PTS can lead to decreased postoperative knee flexion and poor functional outcomes.
Compliance en witwassen in het betaald voetbal: (g)een Belgisch wondermiddel?
Authors: Appermont Niels , Bull William 
Published: May 2023

Compliance and money laundering in professional football: (not) a Belgian panacea?
In recent decades, football has evolved from a purely sporting activity into a global economic phenomenon. Along with this metamorphosis, questions of corporate governance and compliance have come to the fore when it comes to the governance of (professional) football clubs. A good example is the consequences of, and efforts to prevent, criminal activities in the form of money laundering. In recent years, the risks of money laundering activities through the professional football sector have often been highlighted by, for example, European Union institutions. In Belgium, an alleged money laundering scandal in professional football led to legislative measures. This contribution considers the application of Belgium’s preventive anti-money laundering framework to professional football. It concludes that this legal framework is not a miracle solution to the problems facing the sector, and furthermore, the application of this framework raises several questions.
Kickboksen 2.0
Authors: van Gemert Frank 
Published: May 2023

Kickboxing 2.0. On the positive relaunch of a martial art
Kickboxing has undergone a remarkable transformation in the Netherlands in recent decades. The maligned full-contact combat sport with links to the criminal underworld changed into a mainstream activity serving a broad market. This article outlines the background against which this change took place and mentions three levels: national and international society (macro), the gym and the criminal scene (meso), and the fighter and the consumer (micro). In addition to being a martial art, kickboxing is looked upon as a commodity that is put on the market and consumed.
Croissance et production des peuplements d’Acacia mangiun d’âges différents sur le sol sableux du plateau de Batéké/RD Congo
Authors: Polycarpe Mungyeko Mayola Maximain , Lumpungu Kabamba Christophe , Aloni Komanda Jules 
Published: May 2023

La présente étude visait de caractériser les peuplements d’Acacia mangium qui étaient restés en place après la récolte du manioc dans un système agro forestier au village Ibi au plateau de Batéké dans le but d’évaluer leur contribution dans l’offre du bois-énergie aux ménages, des cendres pour l’agriculture et dans la séquestration de carbone pour la lutte contre les gaz à effet de serre, responsables du changement climatique. Cette évaluation, qui avait été menée sur des peuplements d’âges différents (5 âges) : 10, 23, 34, 46 et 84 mois, avait porté sur les paramètres de croissance, du nombre et de types d’espèces dans le sous-bois, ainsi que sur les valeurs en énergie, en cendre et en carbone séquestré. Les résultats ont montré que tous les paramètres étaient influencés par l’âge du peuplement. La croissance en hauteur était de 2 m avec un volume de 1,1m3 à 10 mois, puis elle était montée à 23,2 m de haut et 322,2 m3. ha-1 de volume à 84 mois. La production de la litière était de 0,13 Mg. ha-1 à 10 mois contre 24,9 Mg. ha-1 à 84 mois. Le nombre d’espèce de sous-bois était de 7 à 0 mois (lors de la transplantation) contre zéro à 84 mois, alors que la séquestration de carbone était de 11,17 contre 535,6 tonnes de CO2. ha-1 à 84 mois. L’obtention de l’énergie pour les ménages et de la cendre pour l’agriculture, qui était aussi fonction de l’âge du peuplement, ne pouvait se faire qu’avec le renoncement d’une partie de la séquestration de carbone.
A ABRANGÊNCIA DAS SÉRIES TELEVISIVAS NO ENSINO DE CIÊNCIAS E/OU BIOLOGIA: UMA REVISÃO SISTEMÁTICA DA LITERATURA
Authors: Grossklaus Simone Terezinha , Lubyi Aline , Da Silva Diovana Aparecida Carvalho , De Moraes Bruna Gibowski , Nakalski Eluiza , Borille Josi Mariano , Machado Camila Juraszeck , Silveira Rosemari Monteiro Castilho Foggiatto 
Published: May 2023

Cada vez mais aumenta a busca por estratégias didático-pedagógicas que ultrapassem ou minimizem as dificuldades enfrentadas no processo de ensino-aprendizagem. Nesse tocante, além de estratégia alternativa para a mediação didático-pedagógica, as Tecnologias Digitais de Informação e Comunicação devem ser vistas e ressignificadas como recursos didáticos. Além do que, se deve ter um olhar atento para a Alfabetização Científica e Tecnológica tanto dos professores quanto dos estudantes, que demandam por olhares mais críticos e atentos, principalmente em decorrência das novas relações que ocorrem inteiramente mediadas por essas tecnologias. Esta revisão sistemática da literatura teve como objetivo identificar de que forma as séries televisivas têm sido utilizadas como subsídio para o ensino de Ciências e/ou Biologia. A pesquisa abrangeu a busca por artigos científicos, dissertações e teses associados nas bases de dados Biblioteca Digital Brasileira de Teses e Dissertações, Catálogo de Teses e Dissertações da CAPES e Google Acadêmico. Os termos de pesquisa foram: Série Televisiva, Série de TV, Série de Streaming, Narrativa Seriada, Ensino de Ciências e Ensino de Biologia. Os resultados evidenciaram que são escassos os estudos que relacionam o ensino de Ciências e/ou Biologia com as séries televisivas. Das quatro pesquisas encontradas, um dos trabalhos analisa veementemente a produção midiática sem, no entanto, aplicar o recurso em sala de aula; outro, faz a análise da série enquanto elemento de ensino, traz sugestões de estratégias a partir das análises, porém sem fazer a aplicação do recurso; enquanto que os demais, tanto analisaram quanto aplicaram tal recurso no ambiente escolar. Diante da escassez de trabalhos encontrados, necessita-se que sejam ampliadas as investigações que relacionam as séries televisivas e o ensino de Ciências e/ou Biologia, com intuito de fomentar o potencial dessa abordagem nos diferentes espaços formativos.