bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Spatiotemporal differences in Shrimp ponds using Remote sensing data and Machine learning algorithms
Authors: Bellam Pavan Kumar , Gumma Murali Krishna , Panjala Pranay , Suzuki Aya , Mohammed Ismail 
Published: May 2023

Abstract
Shrimp farming and exporting is the main income source for the southern coastal districts of the Mekong delta. Monitoring these shrimp ponds is helpful in identifying losses incurred due to natural calamities like floods, sources of water pollution by chemicals used in shrimp farming, and changes in the area of cultivation with an increase in demand for shrimp production. Satellite imagery, which is consistent with good spatial resolution and helpful in providing frequent information with temporal imagery, is a better solution for monitoring these shrimp ponds remotely for larger spatial extent. The shrimp ponds of Cai Doi Vam Township, Ca Mau Province, Viet Nam were mapped using DMC-3 (TripleSat) and Jilin-1 high-resolution satellite imagery for years of 2019 and 2022. The 3m spatial resolution shrimp pond extent product showed an overall accuracy of 87.5% with a producer’s accuracy of 90.91% (errors of omission = 11.09%), and a user’s accuracy of 90.91% (errors of commission = 11.09%) for the shrimp pond class. It was noted that 66 ha of shrimp ponds in 2019 were observed to be dry in 2022, and 39 ha of other ponds had been converted into shrimp ponds in 2022. The continuous monitoring of shrimp ponds helps achieve sustainable aquaculture and acts as crucial input for the decision-makers for any interventions.
Evaluating initial responses to brolucizumab in patients undergoing conventional anti- VEGF therapy for diabetic macular edema: A retrospective, single-center, observational study
Authors: Hirano Takao , Kumazaki Akane , Tomihara Ryuji , Ito Syun , Hoshiyama Ken , Murata Toshinori 
Published: May 2023

Abstract
The purpose of our retrospective, single-center, observational study was to evaluate the initial responses to intravitreal injection of brolucizumab (IVBr) in patients undergoing anti-vascular endothelial growth factor (VEGF) therapy for diabetic macular edema (DME). A total of 23 eyes of 20 patients with DME treated with at least one intravitreal injection of ranibizumab or aflibercept within one year and then switched to IVBr were included. Best corrected visual acuity (BCVA), central macular thickness (CMT), and macular volume (MV) on optical coherence tomography images were evaluated just before the most recent conventional anti-VEGF (ranibizumab/aflibercept) injection therapy (V1), one month after the most recent traditional anti-VEGF therapy (V2), just before the first IVBr (V3), and one month after the first IVBr (V4). BCVA, CMT, MV, and the presence of intraocular inflammation (IOI) were evaluated at each visit. Anterior chamber flare values were also examined at V3 and V4. BCVA showed significant improvement at V2(0.30 ± 0.23)than V1 (0.39 ± 0.29) and at V4 (0.34 ± 0.26) than V3 (0.48 ± 0.34), (P = 0.002, P < 0.001). However, no significant difference was observed between V2 and V4 (P = 0.257). CMT was significantly thinner at V2 (346.8 ± 90.2 µm) than V1 (495.5 ± 123.8 µm), and at V4 (322.2 ± 95.7 µm) than V3 (536.5 ± 166.0 µm), (P < 0.001, P < 0.001), but no significant difference was observed between V2 and V4 (P = 0.140). MV was significantly smaller at V2 (11.6 ± 2.0 mm3) than V1 (12.6 ± 1.9 mm3) and at V4 (11.2 ± 2.0 mm3) than at V3 (12.6 ± 2.0 mm3), (P < 0.001, P < 0.001) and even significantly smaller at V4 than at V2 (P = 0.009). None of the patients had IOI. No significant changes were observed in anterior chamber flare values between V3 and V4 (25.6 ± 14.6 vs. 24.0 ± 11.5 photon count/ms; P = 0.543). Both CMT and MV significantly reduced without any adverse events one month after switching from conventional anti-VEGF to IVBr therapy for DME, including IOI. MV was significantly lower for IVBr than anti-VEGF therapy after one month of treatment. Thus, switching to brolucizumab may be a viable treatment option in patients with DME who show poor response to conventional anti-VEGF agents.
Drug treatment for oral submucous fibrosis: a systematic review
Authors: chen xueru , Xie Hui , Guo Jincai 
Published: May 2023

Abstract
Objective
The aim of this review is to evaluate the different medicinal interventions available for the management of oral submucous fibrosis (OSF).
Materials and methods
We searched a comprehensive electronic search on PubMed, Web of Science, and Cochrane Library databases for articles related to OSF patients treated with medications from December 2011 to September 2022. GRADE system was used to evaluate the evidence quality.
Results
Twenty-nine randomized controlled trials (RCTs), six non-RCT studies were included, and the use of drugs for OSF treatment were evaluated. The main outcomes were improvement in mouth opening, burning sensation, cheek flexibility, and tongue protrusion. Drugs like steroids, hyaluronidase, pentoxifylline, lycopene, curcumin, dpirulina, aloe vera, omega3, oxitard, allicin, colchicine have been used. It was found that drugs with evidence high quality were SMI combined with triamcinolone acetonide, lycopene, pentoxifylline, curcumin, and aloe vera, and those with evidence moderate quality were allicin, colchicine, omega 3, and oxitard.
Conclusion
Based on the results of our comprehensive analysis, for long-term treatment, we found lycopene with low side effects, whereas for relieving the symptoms of severe burning sensation, aloe vera is the most effective. Although the resent review has made some progress, drug therapy for OSF remains unclear, and more high-quality RCTs are needed to identify better treatments for OSF.
Deliberate practice and clinical competence of residents: A systematic review and meta-analysis of randomized controlled trials
Authors: Li Jiayin , Tang Anliu , Yang Wenqi , Tang Xiaohong 
Published: May 2023

Abstract
OBJECTIVE: To evaluate the effectiveness of deliberate practice (DP) in improving the clinical competence of residents and its superiority over traditional teaching methods through a meta-analysis of randomized controlled trials (RCTs).
METHODS: A systematic search was conducted of PubMed, EMBASE, Cochrane Library, and Web of Science for relevant literature published through December 12, 2022. All RCTs reporting relationship between DP and clinical competence were included. Two independent reviewers screened according to inclusion and exclusion criteria, followed by quality evaluation, data extraction, and data analysis. We calculated the pooled mean difference (MD) and 95% confidence interval (CI) for residents’ clinical competencies under the DP intervention versus traditional teaching methods in each study and combined these values using standard meta-analysis methods.
RESULTS: Ten RCTs were retrieved with 277 residents. A total of 182 residents were included in the checklist scale. Compared with traditional methods, DP significantly improved the checklist scores and enhanced residents’ clinical competency (MD = 4.44, 95% CI (1.72, 7.15), Z = 3.20, p = 0.001 < 0.05). Further, 66 residents were included in the objective structured assessment of technical skills global rating scale (OSATS GRS). The results showed that there was no significant difference in scores between the intervention group and the blank control group (MD = 1.34, 95% CI (-2.82, 5.51), Z = 0.63, p = 0.53 > 0.05), possibly due to small sample sizes. For other indicators and scales, DP had some effect on improving clinical competence.
CONCLUSIONS: DP has a certain role in improving the clinical competence of residents. Due to the different scales used and the bias of loss to follow-up in the included studies, this finding still needs to be further confirmed by high-quality, multi-center, randomized, blinded, and controlled clinical studies.
META REGISTRATION: Register name: Jiayin Li; Date of registration: 3, Mar 2023; ID: CRD42023403368
TP53 mutation prevalence in normal airway epithelium as a biomarker for lung cancer risk
Authors: Craig Daniel J. , Crawford Erin L. , Chen Heidi , Grogan Eric L. , Deppen Steven A. , Morrison Thomas , Antic Sanja L. , Massion Pierre , Willey James C. 
Published: May 2023

Abstract
Background
There is a need for biomarkers that improve accuracy compared with current demographic risk indices to detect individuals at the highest lung cancer risk. Improved risk determination will enable more effective lung cancer screening and better stratification of lung nodules into high or low-risk category. We previously reported discovery of a biomarker for lung cancer risk characterized by increased prevalence of TP53 somatic mutations in airway epithelial cells (AEC). Here we present results from a validation study in an independent retrospective case-control cohort.
Methods
Targeted next generation sequencing was used to identify mutations within three TP53 exons spanning 193 base pairs in AEC genomic DNA.
Results
TP53 mutation prevalence was significantly associated with cancer status. The lung cancer detection receiver operator characteristic (ROC) area under the curve (AUC) for the TP53 biomarker was 0.845 (95% confidence limits 0.749–0.942). In contrast, TP53 mutation prevalence was not significantly associated with age or smoking status among non-cancer subjects. The combination of TP53 mutation prevalence and Brock Risk Score significantly improved the association with lung cancer compared with either factor alone.
Conclusions
These results support the validity of the TP53 mutation prevalence biomarker and justify taking additional steps to assess this biomarker in AEC specimens from a prospective cohort and in matched nasal brushing specimens as a potential non-invasive surrogate specimen.
Teaching perceptions and practices in environmental education in the high school of the state public network in the city of Juazeiro/Bahia/Brazil
Authors: Silva Charle Jean Alves , Campos Maryluce Albuquerque Silva 
Published: May 2023

Abstract
This study aimed to evaluate the perceptions and practices related to Environmental Education (EE) of high school teachers in the state education network in the municipality of Juazeiro-Brazil. A questionnaire was applied with semi-structured questions referring to educational work and its specificities in six schools. There was a need for adequate training so that the environmental theme, as a dimension of the educational-school process, is understood as a socio-environmental problem. A reflection with profound theoretical rigor is also necessary, which guides the educational actions, to break with the discourse centered exclusively on the ecological perspective that preaches superficial changes.
The Quest for Triglyceride Control: Can a low-starch diet be the answer for Insulin-Resistant Overweight Women?
Authors: Erta Gita , Gersone Gita , Tretjakovs Pēteris 
Published: May 2023

Abstract
Background: Insulin resistance is a condition in which body cells become less responsive to the effects of insulin, leading to elevated blood glucose levels and an increased risk of developing type 2 diabetes and cardiovascular disease. Triglycerides are a type of fat found in the blood that can also contribute to cardiovascular disease risk. There is evidence to suggest that dietary interventions, such as a low-starch diet, may improve triglyceride levels in individuals with insulin resistance.
Methods: In this study, 12 participants with insulin resistance were placed on a low-starch diet for 12 weeks. Blood samples were taken before and after the intervention to measure triglyceride levels. Paired t-tests were used to compare mean triglyceride levels before and after the intervention.
Results: The mean level of triglycerides before the intervention was 1.16, with a standard deviation of 0.56. After the intervention, mean triglyceride levels decreased to 0.98, with a standard deviation of 0.44. The paired t-test showed that there was a significant difference in mean triglyceride levels before and after the intervention (t = 3.41, df = 11, p-value = 0.006). These results suggest that a low-starch diet intervention can be effective in improving triglyceride levels in individuals with insulin resistance.
Conclusion: The findings of this study provide evidence that a low-starch diet may be an effective dietary intervention to improve triglyceride levels in individuals with insulin resistance. However, more research is needed to confirm these findings and determine the long-term effects of a low-starch diet on triglyceride levels and general health outcomes in this population.
The Assessment of cytotoxicity, apoptosis inducing activity and molecular docking of a new ciprofloxacin derivative in human leukemic cells
Authors: Pashapour Neda , Dehghan-Nayeri Mohammad Javad , Babaei Esmaeil , Khalaj-Kondori Mohammad , Mahdavi Majid 
Published: May 2023

Abstract
The fluoroquinolone class of antibiotics includes derivatives of the drug ciprofloxacin. These substances have recently been advocated for the treatment of cancer. In the current study, we examined the cytotoxicity and apoptosis-inducing potential of a novel synthetic ciprofloxacin derivative in the human myeloid leukemia KG1-a cell line. With an IC50 of 25µM, this ciprofloxacin derivative, 7-(4-(2-(benzhydryloxy)-2-oxoethyl) piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4 dihydroquinoline-3- carboxylic acid (4-BHPCP), was an active drug. Through Hoechst 33258 staining and Annexin V/PI double staining experiments, the apoptotic activity of the 4-BHPCP was assessed morphologically. Real-time quantitative PCR was used to assess changes in the expression level of certain apoptosis-related genes, including Bcl-2, Bax, and Survivin (qRT PCR). The results of the qRT PCR analysis demonstrated that 4-BHPCP promotes apoptosis in the KG1-a cell line by down-regulating Survivin and Bcl2, up-regulating Bax, and increasing the Bax/Bcl2 transcripts in a time-dependent manner. These results imply that this novel chemical may be a promising therapy option for acute myeloid leukemia.
A Systematic Review and Meta-analysis of the Prevalence of Schizophrenia in China From 2000 to 2020
Authors: Haiying Jin , Haihan Chen , Tao Hejian , Weidong Jin , Fengli Sun 
Published: May 2023

Abstract
Background
The prevalence of schizophrenia is influenced by many factors.Understanding this change is of academic significance and scientific value.To understand the prevalence of schizophrenia and the trend of nearly twenty years in China, providing scientific basis for early prevention and treatment by meta-analysis.
Methods
A systematic literature retrieval was conducted by using Chinese database for the information about the prevalence of schizophrenia in China published from 2000 to 2020.The quality of literature was evaluated .The prevalence was analyzed by Revman5.2.
Results
Twenty-eight articles were included. The total sample size was 76273830. The prevalence of schizophrenia in China was 3.72 ‰ (95%: 3.30 ‰ - 4.22 ‰). Subgroup analysis showed that there was no significant difference in the prevalence of schizophrenia among cases with different genders(P>0.05) ,among rural and urban(P>0.05),between the years of the survey(P>0.05). The related age range of highest prevalence of schizophrenia was 35-64 years old.
Conclusions
The prevalence of schizophrenia in China is 3.72 ‰. The prevalence rate of Schizophrenia is no difference with genders,urbancity.There was no significant change in prevalence of schizophrenia in the last twenty years.The related age range of highest prevalence of schizophrenia was 35-64 years old.
Poly(ethylene glycol)-b-poly(epsilon-caprolactone) nanoparticles as a platform for the improved oral delivery of cannabidiol
Authors: Shreiber-Livne Inbar , Sulimani Liron , Shapira Anna , Procaccia Shiri , Meiri David , Sosnik Alejandro 
Published: May 2023

Abstract
Cannabidiol (CBD), a non-psychoactive constituent of Cannabis, has proven neuroprotective, anti-inflammatory and antioxidant properties though his therapeutic use, especially by the oral route, is still challenged by the poor aqueous solubility that results in low oral bioavailability. In this work, we investigate the encapsulation of CBD within nanoparticles of a highly hydrophobic poly(ethylene glycol)-b-poly(epsilon-caprolactone) block copolymer produced by a simple and reproducible nanoprecipitation method. The encapsulation efficiency is ~100% and the CBD loading 11% w/w (high performance liquid chromatography). CBD-loaded nanoparticles show a monomodal size distribution with sizes of up to 100 nm (dynamic light scattering), a spherical morphology, and the absence of CBD crystals (high resolution-scanning electron microscopy and cryogenic-transmission electron microscopy) which is in line with a very efficient nanoencapsulation. Then, the CBD release profile from the nanoparticles is assessed under gastric- and intestine-like conditions. At pH 1.2, only 10% of the payload is released after 1 h. Conversely, at pH 6.8, a release of 80% is recorded after 2 h. Finally, oral pharmacokinetics is investigated in rats and compared to a free CBD suspension. CBD-loaded nanoparticles lead to a statistically significant ~20-fold increase of maximum drug concentration in plasma (Cmax) and a shortening of the time to the Cmax (tmax) from 4 to 0.3 h, indicating a more complete and faster absorption than in free form. Moreover, the area-under-the-curve, a measure of oral bioavailability, increase by 14 times. Overall results highlight the promise of this simple, reproducible, and scalable nanotechnology strategy to improve the oral performance of CBD with respect to common oily formulations and/or lipid-based drug delivery systems associated with systemic adverse effects.
Expanding CYLD protein in NF-κβ/TNF-α signaling pathway in response to Lactobacillus acidophilus in non-metastatic rectal cancer patients
Authors: Zamani Farhad , Khalighfard Solmaz , Kalhori Mohammad Reza , Hosseinzadeh Payam , Esmati Ebrahim , Alemrajabi Mahdi , Nikoofar Alireza , Tameshkel Fahimeh Safarnezhad , Alizadeh Ali Mohammad 
Published: May 2023

Abstract
Introduction:
CYLD gene is a tumor suppressor, reducing in many cancers. Here, we aimed to investigate CYLD protein level and NF-κβ/TNF-α signaling pathway in rectal cancer patients with Lactobacillus acidophilus (L. acidophilus) consumption.
Methods:
One hundred ten patients with non-metastatic rectal cancer were randomly divided into L. acidophilus probiotic (500 mg, three times daily) and placebo groups for 13 weeks. The expression of CYLD, TNF-α, and NF-κB proteins and the genes involved in the NF-κβ/TNF-α pathway were evaluated using ELISA and qPCR techniques.The survival rate was measured after five years.
Results:
Unlike the placebo group, the results showed a significant increase in the expression of CYLD protein and tumor suppressor genes, including FOXP3, ROR-γ, Caspase3, GATA3, T-bet, and a considerable decrease in the expression of NF-ҝβ and TNF-α proteins and oncogenes, including STAT3, 4, 5, 6, and SMAD 3, in the probiotic group. A higher overall survival rate was seen after L. acidophilus consumption compared to the placebo group (P < 0.05).
Conclusion:
L. acidophilus consumption can reduce inflammation factors by affecting CYLD protein and its downstream signaling pathways.
Bacterial cellulose-based scaffold: synthesis and surface modification for sustained rifampicin release for topic skin infections treatment
Authors: Yamada Caroline , Lazarini Silmara C. , Amaral Nayara C do , Barud Hernane S. , Mariano-Neto Rafael , Gonçalves Adriano Marques , de Oliveira Guedmiller Souza , Lustri Wilton Rogério 
Published: May 2023

Abstract
The present work aims the production of bacterial cellulose (BC), by Komagataeibacter hansenii, and the surface modifications by methanol treatment to produce membranes with different physical characteristics that allow the use of device for sustained release of the antibacterial drug rifampicin (RIF) with broad spectrum and bactericidal activity against Gram-positive and Gram-negative species, being able to penetrate bacterial biofilms, for potential use as a dressing for the prevention or treatment of SSTIs. Here, BC produced was treated with methanol (BC-MetOH) to obtain optimized membranes for use as sustained release devices for the antibacterial RIF. The parameters evaluated were fiber densities, thickness, and entanglement of BC-MetOH impregnated by RIF in methanolic solution (BC-MetOH-RIF) compared to BC-dH2O impregnated by RIF in aqueous solution (BC-dH2O-RIF) in regarding the capacity for sustained release of RIF. BC-MetOH-RIF and BC-dH2O-RIF were characterized by field emission scanning electron microscopy (FEG-SEM), thermogravimetric analysis, and Fourier transform infrared spectroscopy. The comparison between the sustained release capacity of RIF by BC-RIF-MetOH and BC-RIF-dH2O were analyzed by disc diffusion technique. Intermolecular interactions between RIF and BC were accounted for in water and methanol solutions using molecular dynamics (MD) simulations. Both FEG-SEM and MD simulations demonstrated that the interaction energy of the BC-RIF-MetOH set related to the RIF-BC is stronger in methanol solution than in water. The results obtained demonstrate that BC-RIF-MetOH can contribute to the increase of the therapeutic arsenal for bacterial infections treatment of the SSTIs.
Open reduction and internal fixation of irreducible displaced femoral neck fracture with Femoral Neck System: a preliminary study
Authors: Liang Chengzhi , Cao Yuan , Lin Zhihao , Liu Guoming , Zhang Chengdong , Hu Yanling 
Published: May 2023

Abstract
Background Most displaced femoral neck fractures can achieve satisfactory anatomical reduction by closed reduction, but there are still some that cannot reset satisfactorily after closed reduction, and open reduction are required. Such fractures that cannot be repositioned successfully by closed reduction are called irreducible displaced femoral neck fractures in this study. The objective of our study was to evaluate the efficacy of direct anterior incision with the Femoral Neck System in the treatment of irreducible displaced femoral fractures.Methods A total of 16 young and middle-aged patients with irreducible displaced femoral neck fractures involving Garden type III and IV were treated using Femoral Neck System fixation by open reduction through Direct Anterior Approach between January 2020 to September 2021. Functional outcomes and postoperative complications were assessed during follow-up. Clinical outcomes were evaluated by the Hip Harris score. The postoperative reduction was evaluated by the Garden Index. Observe postoperative complications.Results All patients were followed up with a mean follow-up time of 21.1(12–30) months, and according to radiological results, all patients achieved fracture healing, with a mean healing time of 4.25 months. All 16 patients received grade Garden I and II reductions, and there was no significant difference in the anteroposterior Garden reduction index between the first day after surgery (166.13 ± 5.61) and the 12th month after surgery(164.94 ± 4.49) (P༞0.05) and no significant difference in lateral Garden index between the first day after surgery(171.06 ± 4.46) and the 12th month after surgery(169.38 ± 3.98) (P༞0.05). According to the Hip Harris score scale, 13 patients received excellent and 3 patients received good. The postoperative Hip Harris Score(17.19 ± 4.8) was significantly higher than the preoperative score(92.19 ± 3.4), and the difference was statistically significant (P < 0.05). No or mild femoral neck shortness occurred in 12 (75%) patients, moderate shortening occurred in 3 (18.75%) patients, and severe shortening occurred in 1 (6.25%) patient. None of the patients experienced femoral head necrosis, fracture nonunion, or incision infection. One patient developed deep venous thrombosis of lower extremity.Conclusions The Direct Anterior Approach combined with Femoral Neck System is an excellent treatment for irreducible displaced femoral neck fracture and achieved good functional outcomes and anatomical reduction with low complications.