bluuebunny/crossref_metadata_2025_split huggingface dataset:
Training Periodization, Intensity Distribution, and Volume in Trained Cyclists: A Systematic Review
Authors: Galán-Rioja Miguel Ángel , Gonzalez-Ravé José María , González-Mohíno Fernando , Seiler Stephen 
Published: January 2023

A well-planned periodized approach endeavors to allow road cyclists to achieve peak performance when their most important competitions are held. Purpose: To identify the main characteristics of periodization models and physiological parameters of trained road cyclists as described by discernable training intensity distribution (TID), volume, and periodization models. Methods: The electronic databases Scopus, PubMed, and Web of Science were searched using a comprehensive list of relevant terms. Studies that investigated the effect of the periodization of training in cyclists and described training load (volume, TID) and periodization details were included in the systematic review. Results: Seven studies met the inclusion criteria. Block periodization (characterized by employment of highly concentrated training workload phases) ranged between 1- and 8-week blocks of high-, medium-, or low-intensity training. Training volume ranged from 8.75 to 11.68 h·wk–1 and both pyramidal and polarized TID were used. Traditional periodization (characterized by a first period of high-volume/low-intensity training, before reducing volume and increasing the proportion of high-intensity training) was characterized by a cyclic progressive increase in training load, the training volume ranged from 7.5 to 10.76 h·wk–1, and pyramidal TID was used. Block periodization improved maximum oxygen uptake (VO2max), peak aerobic power, lactate, and ventilatory thresholds, while traditional periodization improved VO2max, peak aerobic power, and lactate thresholds. In addition, a day-by-day programming approach improved VO2max and ventilatory thresholds. Conclusions: No evidence is currently available favoring a specific periodization model during 8 to 12 weeks in trained road cyclists. However, few studies have examined seasonal impact of different periodization models in a systematic way.
Social App to Improve Warfarin Therapy in Post-MHVR Chinese Patients: A Randomized Controlled Trial
Authors: Zhang Litao , Li Sha , Li Zishuo , Yu Dan , Wu Haiyan , Hua Bing , Xie Li , Yuan Xia , Li Yun , Zhang Zhenlu , Long Yanli 
Published: January 2023

Background. Poor anticoagulation quality was a major problem among warfarin-treated patients, which called for innovative and effective methods to improve it. Objective. To investigate whether social app could be used to reduce warfarin-associated adverse events among post-MHVR Chinese patients. Method. 735 warfarin-treated patients (

aged

50.8
±
9.6

years

, 59.9% female) were enrolled and randomized to a social app care group (warfarin therapy was guided by experienced clinicians via a social app) or a routine care group (warfarin therapy was managed through traditional in-office visits) at a 1 : 1 ratio. Ending points (bleeding and thrombotic events) were recorded during an 18-month follow-up period. Results. A total of 718 patients were included in analysis. 57 of them suffered warfarin-associated adverse events, including 30 major bleedings and 27 thrombotic events. The time in the therapeutic range (TTR, Rosendaal method) in the social app group was 71.5%, which was significantly better than 52.6% in the routine care group (difference: 18.8%, 95% CI: 16.8-20.8). Compared with the patients from the social app group, patients under routine care experienced more bleeding (hazard ratio (HR): 2.31, 95% CI: 1.13-4.72). The social app care group had lower variation (0.55 vs. 0.70) in the international normalized ratio (INR) values and fewer incidents of extremely high INR (e.g.,

INR
>
5.0

, 0.87% vs. 3.42%) than the routine care group. Conclusions. Social app management could significantly improve warfarin control and was associated with a reduction in bleeding risk. This trial was registered with NCT03264937.
Funerary Rites and Rights of the Dead: Jurisprudence on covid-19 Deaths in Kenya, India and Sri Lanka
Authors: Nyamutata Conrad 
Published: January 2023

Abstract
Pandemics are associated with exponential mortality rates, creating heavy burdens on communities. The high death rates affect how societies traditionally conduct funerary practices as governments impose regulations on the preparation of bodies and the conduct of the funerals to stem the transmission of the virus. In societies associated with deeply entrenched customary funerary practices, such limitative measures attract defiance. The tensions between public health objectives and funerary traditions have played out in a number of societies resulting in litigation. At the core of the disputes is whether the right to manifest religion or belief can be upheld, and relatedly, whether the dead have rights to dignified burials irrespective of pandemics. During the covid-19 pandemic, some courts had to grapple with these difficult questions. In this paper, I take a jurisprudential excursion on some disputes in Kenya, India and Sri Lanka to assess the adjudication of conflicts which arose from covid-19 pandemic deaths.
Short- and mid-term outcomes in systemic lupus erythematosus patients presenting with disease exacerbation after SARS-CoV-2 mRNA vaccination: A cohort study from Puerto Rico
Authors: González-Meléndez Ariana , Báez-Negrón Laisha , Ríos-Rivera Rafael , Franco-O’Connell Alexandra S , Nieves-Plaza Mariely , Vilá Luis M 
Published: January 2023

Objective To determine if SARS-CoV-2 mRNA vaccination has an impact on the clinical course of systemic lupus erythematosus (SLE). Methods Puerto Ricans with SLE who received mRNA COVID-19 vaccines were studied. Demographic parameters, clinical manifestations, disease activity (per Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), disease damage (per Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index), emergency room visits, hospitalizations, and pharmacologic therapy were determined. Baseline variables (prior to vaccination) were compared between patients with and without exacerbation after SARS-CoV-2 vaccination. Among those with exacerbation, clinical outcomes were determined up to 1 year after vaccination. Results Of the entire cohort ( n = 247), 14 (5.7%) had post-vaccination exacerbations. Photosensitivity, oral ulcers, anti-Ro antibodies, higher SLEDAI score, and corticosteroids exposure were associated with post-vaccination flares. Among those with post-vaccination flares, 10 (71.4%) had major organ involvement. No significant differences were observed for mean SLEDAI scores, emergency room visits, hospitalizations, disease damage, and exposure to immunosuppressive drugs before and after SARS-CoV-2 mRNA vaccination. At 12 months of follow-up, all patients were fully controlled without evidence of active disease. Conclusion In our group of SLE patients, 5.7% had a disease flare after SARS-CoV-2 mRNA vaccination. Most had exacerbations involving major organs/systems. Mucocutaneous manifestations, anti-Ro antibodies, disease activity, and corticosteroids were associated with flares. Awareness of these factors and the possibility of a major lupus flare after vaccination with COVD-19 vaccines is critical to provide timely and effective therapy.
Comparison of Sedation and Analgesia Requirements in Patients With SARS-CoV-2 Versus Non-SARS-CoV-2 Acute Respiratory Distress Syndrome on Veno-Venous ECMO
Authors: Sigala Mariah I. , Dreucean Diane , Harris Jesse E. , Donahue Kevin R. , Bostan Fariedeh , Voore Prakruthi , Cuevas Jose , Morton Celia 
Published: January 2023

Background: Increased analgosedation requirements have been described in patients with acute respiratory distress syndrome (ARDS) on extracorporeal membrane oxygenation (ECMO) support due to unique pharmacokinetic challenges. There is a paucity of data comparing sedation requirements in patients on ECMO for ARDS secondary to SARS-CoV-2 versus other etiologies of respiratory failure. Objective: To compare sedation and analgesia requirements in adult patients with SARS-CoV-2 versus non-SARS-CoV-2 ARDS requiring veno-venous (VV) ECMO support. Methods: We performed a retrospective cohort study of adult patients receiving sedation and analgesia on VV-ECMO support. Patients were excluded if cannulated at an outside hospital for greater than 24 hours, expired within 48 hours of ECMO cannulation, or received neuromuscular blocking agents for greater than 7 consecutive days following ECMO cannulation. Results: We evaluated 108 patients on VV-ECMO support, including 44 with non-SARS-CoV-2 ARDS and 64 with SARS-CoV-2 ARDS. The median daily dexmedetomidine requirements were significantly higher in the SARS-CoV-2 cohort (16.7 vs 13.4 mcg/kg/day, P = 0.03), while the median propofol daily requirements were significantly higher in the non-SARS-CoV-2 cohort (40.3 vs 53.5 mg/kg/day, P < 0.01). There was no difference in daily requirements of opioids, benzodiazepines, and ketamine between groups. Use of adjunct agents to facilitate weaning was significantly higher in the SARS-CoV-2 cohort (78.1% vs 43.2%, P < 0.01). Conclusion and Relevance: Patients with ARDS on VV-ECMO support require multiple analgosedative agents with concomitant use of nonparenteral adjunct agents. Further studies are needed to evaluate optimal analgosedation strategies in patients on ECMO support.
Influence of Weightbearing Computed Tomography in the Progressive Collapsing Foot Deformity Classification System
Authors: Barbachan Mansur Nacime Salomão , Lalevée Matthieu , Lee Hee Young , Ehret Amanda , Fayed Aly , Mann Tania Szejnfeld , de Carvalho Kepler Alencar Mendes , de Cesar Netto Cesar 
Published: January 2023

Background: The objective of this study was to compare progressive collapsing foot deformity (PCFD) classifications performed using clinical and conventional radiographs (CR) with classifications established using clinical and weightbearing computed tomography (WBCT). Methods: This retrospective comparative study evaluated 89 consecutive PCFD feet (84 patients). Three readers performed chart reviews and CR evaluations, determining PCFD classifications that were previously published. After a washout period, the sequence was randomized, and a new classification was executed using clinical and WBCT assessment. One of the readers repeated the WBCT evaluation for intrarater reliability. Results: Interrater reliability for the WBCT was found moderate (0.55) and intrarater excellent (0.98). Evaluation using WBCT produced 29.6% of 1ABC (CR: 25.4%, P = .270), 11.6% of 1ABCD (CR: 6.9%, P = .081), and 6.4% of BC (CR: 3.3%, P = .090) as most prevalent. Class A was presented in 83.9% (CR: 89.5%, P = .55), class B in 89.9% (CR: 76.4%, P < .001), class C in 93.6% (CR: 86.2%, P = .004), class D in 46.4% (CR: 34.8%, P = .006), and class E in 27.7% (CR: 22.5%, P = .158) of the classifications performed by WBCT. Conclusion: WBCT showed a different rate of deformity recognition, which increased the incidence of all classes, especially B, C, and D. An excellent intrarater agreement was found, which infers assessment reliability combining clinical and WBCT evaluation. The obtained information could enhance disease understanding and supply patients with more precise care. Level of Evidence: Level III, retrospective comparative study.
Randomized Control Trial of a School-Based Curriculum that Teaches About Multiple Forms of Abuse
Authors: Bright Melissa A. , Huq Mona Sayedul , Miller M. David , Patel Shivam , Li Ziying , Finkelhor David 
Published: January 2023

Most school-based prevention curricula for young children fail to address multiple types of abuse and limit instruction to a single day, despite evidence that polyvictimization is common and children learn better when allowed to practice material repeatedly. This study utilized a cluster randomized control trial design to evaluate a multi-abuse prevention program, the Monique Burr Foundation for Children (MBF) Child Safety Matters®, based on varying lesson structure. Participants included nine Florida schools consisting of 843 children in grades K-2. Schools were randomized within cluster to implement in two lessons, four lessons, or after study data collection (i.e., control group). Lessons averaged 34 minutes ( SD = 8.8 minutes) in length for 2-lesson group and 23.6 minutes ( SD = 6.9 minutes) for the 4-lesson condition. Knowledge was assessed before implementation and on average 11 weeks after implementation. There were no statistical differences between clusters. Controlling for pre-test scores, schools in the four-lesson group scored highest on a measure of knowledge of potentially risky and unsafe situations ( M = 69.68, SE = .80) on post-test, followed by schools in the two-lesson group ( M = 67.31, SE = .77), followed by schools in the control group ( M = 62.92, SE = .76). Results support use of more frequent, shorter lessons for prevention programs and the promise of addressing multiple forms of child victimization.
PM2.5 exposure and lung function impairment among fiber-cement industry workers
Authors: Nasri Sjahrul Meizar , Putri Fiori Amelia , Sunarno Stevan , Fauzia Sifa , Ramdhan Doni Hikmat 
Published: January 2023

Introduction: Numerous studies have reported respiratory impairment by exposure to fine particulate matter (PM2.5). However, limited studies investigated its effects on fiber cement roof workers. Thus, our study evaluated the impact of PM2.5 on pulmonary impairments among workers and its risk factors. Design and Method: A total of 131 fiber cement roof workers have been chosen based on the inclusive criteria. Size-segregated particles were measured in the workplace of workers. Interview and spirometry tests were obtained to determine the respiratory impairments. Result: The results showed the mean concentrations of PM2.5 had exceeded the WHO and US-EPA standards. A quarter of workers had lung restriction, lung obstruction, and mixed. Workers are most likely to have shortness of breath and wheezing. A significant correlation was found between smoking, production workers, and a long work period with abnormal lung function. Fiber cement roof workers are significantly at risk of exposure to PM2.5. They are most likely to acquire abnormal lung function due to PM2.5 exposure. Conclusion: Our study recommended the industry constantly maintain its programs. The industry should keep using the wet process to prevent dust generation and water suppression from preventing dust spread, as well as to wear respiratory protection for workers to avoid PM2.5 exposure. We recommended as well to the industry to implement follow-up programs for workers with abnormal lung function. Further action is needed to protect the workers’ occupational health in the fiber cement roof industry.
Effect of Cross-sectional Area of the Hamstring Tendon Autograft on Failure Rate or Clinical Outcomes After Double-Bundle ACL Reconstruction: Tendon Autograft
Authors: Onishi Shintaro , Iseki Tomoya , Kanto Ryo , Nakayama Hiroshi , Oka Shinya , Matsumoto Akio , Tachibana Toshiya , Yoshiya Shinichi , Yamaguchi Motoi 
Published: January 2023

Background: In previous studies examining the relationship between graft size and failure rate after anterior cruciate ligament reconstruction (ACLR), graft size was determined as diameter of the bone tunnel, and graft failure was defined as revision surgery. Consequently, the correlation between graft size and postoperative recurrent instability could not be assessed. Purpose: (1) To intraoperatively measure the cross-sectional area (CSA) of the hamstring tendon (HT) autograft and compare the CSA of the autograft with the bone tunnel and (2) to assess the effect of the graft CSA on postoperative graft failure among patients who underwent double-bundle ACLR. Study Design: Case-control study; Level of evidence, 3. Methods: The study included 129 patients who underwent double-bundle ACLR using an HT autograft (mean ± SD age, 16.7 ± 1.7 years; all with a Tegner activity level ≥6). All patients had a minimum follow-up of 2 years. During surgery, the graft CSA was measured using an area micrometer, combining the anteromedial (AM) and posterolateral (PL) grafts. The total area of the bone tunnel was defined as the combined CSAs of the AM and PL tunnels as calculated by the diameter of the drill. The relationship between the CSAs of the combined HT graft and the bone tunnel was statistically compared, as was the relationship between graft CSAs and graft failure, defined as reinjury, recurrent instability manifested as quantitative laxity measurement, or revision ACLR. Results: The CSAs of the midsubstance of the combined AM and PL graft significantly correlated with those of the bone tunnels (femoral side, R 2 = 0.334, P < .0001; tibial side, R 2 = 0.421, P < .0001). As for the relationship between the graft CSA and ACLR failure, there was no significant difference in the graft CSAs between the groups with and without graft failure in any of the failure criteria ( P = .188). Conclusion: The graft CSA was not a predictor of early failure after double-bundle ACLR using an HT autograft in this patient population.
Transcriptomic profiling reveals differences in the adaptation of two Tetragenococcus halophilus strains to a lupine moromi model medium
Authors: Link Tobias , Ehrmann Matthias A. 
Published: January 2023

Abstract
Background
Tetragenococcus (T.) halophilus is a common member of the microbial consortia of food fermented under high salt conditions. These comprises salty condiments based on soy or lupine beans, fish sauce, shrimp paste and brined anchovies. Within these fermentations this lactic acid bacterium (LAB) is responsible for the formation of lactic and other short chain acids that contribute to the flavor and lower the pH of the product. In this study, we investigated the transcriptomic profile of the two T. halophilus strains TMW 2.2254 and TMW 2.2256 in a lupine moromi model medium supplied with galactose. To get further insights into which genomic trait is important, we used a setup with two strains. That way we can determine if strain dependent pathways contribute to the overall fitness. These strains differ in the ability to utilize L-arginine, L-aspartate, L-arabinose, D-sorbitol, glycerol, D-lactose or D-melibiose. The lupine moromi model medium is an adapted version of the regular MRS medium supplied with lupine peptone instead of casein peptone and meat extract, to simulate the amino acid availabilities in lupine moromi.

Results
The transcriptomic profiles of the T. halophilus strains TMW 2.2254 and TMW 2.2256 in a lupine peptone-based model media supplied with galactose, used as simulation media for a lupine seasoning sauce fermentation, were compared to the determine potentially important traits. Both strains, have a great overlap in their response to the culture conditions but some strain specific features such as the utilization of glycerol, sorbitol and arginine contribute to the overall fitness of the strain TMW 2.2256. Interestingly, although both strains have two non-identical copies of the tagatose-6P pathway and the Leloir pathway increased under the same conditions, TMW 2.2256 prefers the degradation via the tagatose-6P pathway while TMW 2.2254 does not. Furthermore, TMW 2.2256 shows an increase in pathways required for balancing out the intracellular NADH/NADH+ ratios.

Conclusions
Our study reveals for the first time, that both versions of tagatose-6P pathways encoded in both strains are simultaneously active together with the Leloir pathway and contribute to the degradation of galactose. These findings will help to understand the strain dependent features that might be required for a starter strain in lupine moromi.
Insights into the phylogeny and chloroplast genome evolution of Eriocaulon (Eriocaulaceae)
Authors: Li Enze , Liu Kangjia , Deng Rongyan , Gao Yongwei , Liu Xinyu , Dong Wenpan , Zhang Zhixiang 
Published: January 2023

AbstractBackgroundEriocaulonis a wetland plant genus with important ecological value, and one of the famous taxonomically challenging groups among angiosperms, mainly due to the high intraspecific diversity and low interspecific variation in the morphological characters of species within this genus. In this study, 22 samples representing 15Eriocaulonspecies from China, were sequenced and combined with published samples ofEriocaulonto test the phylogenetic resolution using the complete chloroplast genome. Furthermore, comparative analyses of the chloroplast genomes were performed to investigate the chloroplast genome evolution ofEriocaulon.ResultsThe 22Eriocaulonchloroplast genomes and the nine published samples were proved highly similar in genome size, gene content, and order. TheEriocaulonchloroplast genomes exhibited typical quadripartite structures with lengths from 150,222 bp to 151,584 bp. Comparative analyses revealed that four mutation hotspot regions (psbK-trnS,trnE-trnT,ndhF-rpl32, andycf1) could serve as effective molecular markers for further phylogenetic analyses and species identification ofEriocaulonspecies. Phylogenetic results supportedEriocaulonas a monophyletic group. The identified relationships supported the taxonomic treatment of sectionHeterochitonandLeucantherae, and the sectionHeterochitonwas the first divergent group. Phylogenetic tree supportedEriocaulonwas divided into five clades. The divergence times indicated that all the sections diverged in the later Miocene and most of the extantEriocaulonspecies diverged in the Quaternary. The phylogeny and divergence times supported rapid radiation occurred in the evolution history ofEriocaulon.ConclusionOur study mostly supported the taxonomic treatment at the section level forEriocaulonspecies in China and demonstrated the power of phylogenetic resolution using whole chloroplast genome sequences. Comparative analyses of theEriocaulonchloroplast genome developed molecular markers that can help us better identify and understand the evolutionary history ofEriocaulonspecies in the future.