bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of positive psychology on the competence and compressive ability of “double qualified” university teachers
Authors: Wang Xiaowei , Wang Xiaoxue , Ma Dayong 
Published: March 2023

BackgroundWith the spread of COVID-19, in application-oriented undergraduate colleges, the difficulty of teaching work for “double-qualified” teachers has greatly increased, resulting in enormous work pressure for some teachers, which is not conducive to the development of teaching work and the physical and mental health of teachers.Subjects and MethodsTwenty “double qualified” teachers from a domestic finance and economics college were selected and divided into an experience group and a control group. The evaluation index system of college teachers’ competency and anti-pressure ability is constructed by using hesitant fuzzy language. Teachers in the experience group were trained in positive psychology, and their competency and anti-pressure ability were evaluated before and after the experiment using the evaluation model. The evaluation grade is divided into poor, general, relatively good, good and excellent, and is assigned with integers 1-5 respectively. The measurement type data is displayed in the form of mean ± standard deviation, and the t difference significance test is conducted. The difference significance level is 0.05.ResultsAfter completing the experiment, the statistics are shown in Table 1. Observation Table 1 shows that before the experiment, the P value of the t-test for the competency and compression resistance scores of the two groups of teachers is far greater than 0.05, with no significant difference. However, after the completion of the experiment, the average scores of teachers’ competency and compressive capacity in the experience group were 4.52 and 4.63, respectively, higher than those in the control group, and the P value of the t-test was 0.001, which was considered significant.Table 1.Comparison of competence and compressive ability scores of two groups of “double qualified” financial teachersCompetencyCompressive capacity-Experience groupControl grouptPExperience groupControl grouptPBefore experiment3.15±0.143.15±0.170.4851.5263.88±0.203.86±0.240.5711.639After experiment4.52±0.273.16±0.192.8620.0024.63±0.313.85±0.223.3760.001t3.2150.448--3.8940.472--P0.0011.569--0.0011.738--ConclusionsThis research carried out experiments to verify the effect of positive psychological intervention on improving the competency and psychological pressure resistance of “double qualified” teachers. The experimental results showed that the post-competence and anti-pressure ability of the financial “double qualified” teachers in the experience group after positive psychological intervention were higher than those in the control group, and the difference was significant. The experimental results show that positive psychology training is conducive to improving the negative psychological pressure resistance of the “double qualified” teachers in China, so as to enhance their post competency.
Intervention effect of drama management combined with mental health education on dissociative anxiety disorder
Authors: Liu Min , Li Ronghua 
Published: March 2023

BackgroundDissociative anxiety disorder in student group is a common mental disorder in the learning process of students. When students are separated from their attachment objects, they will have extremely strong resistance psychology, which will lead to their excessive dissociative anxiety. Dissociative anxiety disorder will lead to more abnormal behaviors and emotions in their life and study. How to alleviate students’ dissociative anxiety disorder has become the focus of current education research.Subjects and MethodsIn this study, 68 students were diagnosed as dissociative anxiety disorder in a school and they were randomly divided into experimental group and control group, with 34 in each group. The students in the control group adopted routine mental health education during the treatment, while the students in the experimental group combined drama management strategies on the basis of mental health education. Finally, evaluate the changes and differences of dissociative anxiety between the two groups.ResultsThe comparison results of the two groups of students are shown in Table 1. Table 1 shows that the anxiety scores of students in the experimental group are significantly lower than those in the control group, and the scores of behavior control and emotional response of students in the experimental group are also significantly lower than those in the control group after treatment, with a statistically significant difference.Table 1.Differences in the evaluation of the two groups of studentsIndexBefore treatmentAfter treatmentExperimental groupControl groupExperimental groupControl groupAnxiety score33.08±8.1432.97±8.336.17±3.0211.15±3.28Behavior control2.52±0.282.47±0.271.71±0.192.35±0.21Emotional response2.31±0.232.45±0.202.08±0.202.33±0.21ConclusionsStudents’ dissociative anxiety disorder has seriously affected students’ life and learning progress, so it is very important to alleviate students’ dissociative anxiety disorder. In the study, an intervention strategy combining drama management and mental health education was proposed. Through experimental verification, this strategy can significantly reduce students’ anxiety scores, and alleviate students’ anxiety behaviors and emotions. Therefore, in education and teaching, it is feasible to introduce drama management strategies to enhance the cultivation of students’ mental health, which is of great significance to the improvement of education quality and students’ growth.
Severity reduction and private market distortion effects of voluntary and mandatory public annuity plans
Authors: Lau Sau-Him P. , Zhang Qilin 
Published: March 2023

AbstractMany economies have recently adopted the defined-contribution retirement financing system, but one disadvantage of this system is that retirees have to bear longevity risk. As a result, several economies have also introduced the public annuity plans. We analyze the similarities and differences between voluntary public annuity with ceiling (VPAc) plan and mandatory public annuity with flexibility (MPAf) plan that are empirically observed. Introducing either plan reduces the severity of adverse selection in public annuities, but further distorts the private annuity market. These two plans have systematically different effects on retirees’ utility levels: the good health group is adversely affected and the average health group benefits. On the other hand, the poor health group benefits from the VPAc plan but may be adversely affected under the MPAf plan.
How a second language and its future time reference impacts intertemporal decision: A holistic perspective
Authors: Xu Yuepei , Wu Chenggang , Zhang Yang-Yang , Liang Zhu-Yuan 
Published: March 2023

AbstractSince globalization, using second languages (L2) to make decisions about future is more common than ever. In this study, we tested the merged effect of two language features, i.e., the future-time reference (FTR) and L2, on intertemporal decision and its indirect mediators, future orientation, and subjective future perception. As a pair of languages with different FTR, English (strong-FTR) has a clear grammatical separation between present and future, while Chinese (weak-FTR) does not. Here, Chinese first language (L1) speakers made intertemporal decisions using either Chinese (L1) or English (L2). Across three studies (N = 1022) and an internal meta-analysis, we found that using a strong-FTR L2 did not change participants’ intertemporal preference but did reduce their future orientation. These findings highlight a holistic perspective merging language features, outcome variables and measurement methods. These findings also imply a need for caution to use second language as nudge strategy in intertemporal decision-making.
Signal enhancement for two-dimensional cryo-EM data processing
Authors: Sharon Guy , Shkolnisky Yoel , Bendory Tamir 
Published: March 2023

Abstract
Different tasks in the computational pipeline of single-particle cryo-electron microscopy (cryo-EM) require enhancing the quality of the highly noisy raw images. To this end, we develop an efficient algorithm for signal enhancement of cryo-EM images. The enhanced images can be used for a variety of downstream tasks, such as two-dimensional classification, removing uninformative images, constructing ab initio models, generating templates for particle picking, providing a quick assessment of the data set, dimensionality reduction, and symmetry detection. The algorithm includes built-in quality measures to assess its performance and alleviate the risk of model bias. We demonstrate the effectiveness of the proposed algorithm on several experimental data sets. In particular, we show that the quality of the resulting images is high enough to produce ab initio models of

$ \sim 10 $

Å resolution. The algorithm is accompanied by a publicly available, documented, and easy-to-use code.
The Post‐Perovskite Transition in Fe‐ and Al‐Bearing Bridgmanite: Effects on Seismic Observables
Authors: Wentzcovitch Renata M. , Valencia‐Cardona Juan J. , Zhuang Jingyi , Shukla Gaurav , Sarkar Kanchan 
Published: March 2023

AbstractThe primary phase of the Earth’s lower mantle, (Al, Fe)‐bearing bridgmanite, transitions to the post‐perovskite (PPv) phase at Earth’s deep mantle conditions. Despite extensive experimental and ab initio investigations, there are still important aspects of this transformation that need clarification. Here, we address this transition in (Al3+, Fe3+)‐, (Al3+)‐, (Fe2+)‐, and (Fe3+)‐bearing bridgmanite using ab initio calculations and validate our results against experiments on similar compositions. Consistent with experiments, our results show that the onset transition pressure and the width of the two‐phase region depend distinctly on the chemical composition: (a) Fe3+‐, Al3+‐, or (Al3+, Fe3+)‐alloying increases the transition pressure, while Fe2+‐alloying has the opposite effect; (b) in the absence of coexisting phases, the pressure‐depth range of the Pv‐PPv transition is likely too broad to cause a sharp D” discontinuity (<30 km); (c) the average Clapeyron slope of the two‐phase regions are consistent with previous measurements, calculations in MgSiO3, and inferences from seismic data. In addition, (d) we observe a softening of the bulk modulus in the two‐phase region. The consistency between our results and experiments gives us the confidence to proceed and examine this transition in aggregates with different compositions computationally, which will be fundamental for resolving the most likely chemical composition of the D" region by analyses of tomographic images.
Phytoplankton Patches at Oceanic Fronts Are Linked to Coastal Upwelling Pulses: Observations and Implications in the California Current System
Authors: Gangrade Shailja , Franks Peter J. S. 
Published: March 2023

AbstractLocally enhanced biological production and increased carbon export are persistent features at oceanic density fronts. Studies often assume biological properties are uniform along fronts or hypothesize that along‐ and across‐front gradients reflect physical‐biological processes occurring in the front. However, the residence times of waters in fronts are often shorter than biological response times. Thus, an alternate—often untested—hypothesis is that observed biological patchiness originates upstream of a front. To test these two hypotheses, we explore an eddy‐associated front in the California Current System sampled during two surveys, separated by 3 weeks. Patches of high phytoplankton biomass were found at the northern ends of both surveys, and phytoplankton biomass decreased along the front. While these patches occurred in similar locations, it was unclear whether the same patch was sampled twice, or whether the two patches were different. Using an advection‐reaction framework combined with field and satellite data, we found that variations in along‐front gradients in dissolved oxygen, particle biovolume, and salinity support the conclusion that the two phytoplankton patches were different. They were only coincidentally sampled in similar locations. Backward‐ and forward‐in‐time tracking of water parcels showed that these phytoplankton patches had distinct origins, associated with specific, strong coastal upwelling pulses upstream of the front. Phytoplankton grew in these recently upwelled waters as they advected into and along the frontal system. By considering both local and upstream physical‐biological forcings, this approach enables better characterizations of critical physical and biogeochemical processes that occur at fronts across spatial and temporal scales.
Characteristic Research on Electromagnetic Response of Two‐Dimensional Complex Structure Targets Based on Meshless Method
Authors: Ji Yanju , Yu Yibing , Zhao Xuejiao , Wu Yanqi , Li Dongsheng , Guan Shanshan , Gao Quanming 
Published: March 2023

AbstractActual geological targets exhibit complex structures and fine grids can improve the modeling accuracy. However, the generation of fine grids is usually difficult. Moreover, the traditional apparent resistivity method can only obtain the approximate range of the target, and cannot accurately distinguish complex structures, including surface and interior complex structures. To address the above problems, this paper proposed to use the meshless method to model complex structure targets. Two‐dimensional (2D) numerical simulation of the electromagnetic (EM) response was performed in the frequency domain. The average relative error was 2.88% compared to the analytical solution. Furthermore, an analysis method of relative difference in the apparent resistivity (Da) was proposed, and the Da between irregular target and regular target was calculated. Two kinds of irregular targets were designed, one was a complex surface target with concave or convex semicircles embedded on the surface, the other was a complex interior target with high and low resistivity anomalies embedded inside. The calculation and analysis results show that the Da method can characterize the electrical difference caused by structure change compared with the traditional method. Our proposed method can facilitate the accurate detection of the surface and interior structure in the target and promote the development of EM methods in the field of complex geological resource detection.
Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis
Authors: Potts Margaret A. , Mizutani Shinsuke , Garnham Alexandra L. , Li Wai Suen Connie S. N. , Kueh Andrew J. , Tai Lin , Pal Martin , Strasser Andreas , Herold Marco J. 
Published: March 2023

AbstractMany lymphoid malignancies arise from deregulated c-MYC expression in cooperation with additional genetic lesions. While many of these cooperative genetic lesions have been discovered and their functions characterised, DNA sequence data of primary patient samples suggest that many more do exist. However, the nature of their contributions to c-MYC driven lymphomagenesis have not yet been investigated. We identified TFAP4 as a potent suppressor of c-MYC driven lymphoma development in a previous genome-wide CRISPR knockout screen in primary cells in vivo [1]. CRISPR deletion of TFAP4 in Eµ-MYC transgenic haematopoietic stem and progenitor cells (HSPCs) and transplantation of these manipulated HSPCs into lethally irradiated animals significantly accelerated c-MYC-driven lymphoma development. Interestingly, TFAP4 deficient Eµ-MYC lymphomas all arose at the pre-B cell stage of B cell development. This observation prompted us to characterise the transcriptional profile of pre-B cells from pre-leukaemic mice transplanted with Eµ-MYC/Cas9 HSPCs that had been transduced with sgRNAs targeting TFAP4. This analysis revealed that TFAP4 deletion reduced expression of several master regulators of B cell differentiation, such as Spi1, SpiB and Pax5, which are direct target genes of both TFAP4 and MYC. We therefore conclude that loss of TFAP4 leads to a block in differentiation during early B cell development, thereby accelerating c-MYC-driven lymphoma development.
PVT1 inhibition stimulates anti-tumor immunity, prevents metastasis, and depletes cancer stem cells in squamous cell carcinoma
Authors: Qin Zhen , Zhang Wenbo , Liu Shuo , Wang Yujia , Peng Xin , Jia Lingfei 
Published: March 2023

AbstractCancer stem cells (CSCs) cause tumor metastasis and immune evasion by as-yet-unknown molecular mechanisms. In the present study, we identify a long noncoding RNA (lncRNA), termed PVT1, which is highly expressed in CSCs and correlated closely with lymph node metastasis of head and neck squamous cell carcinoma (HNSCC). PVT1 inhibition eliminates CSCs, prevents metastasis, and stimulates anti-tumor immunity, while inhibiting HNSCC growth. Moreover, PVT1 inhibition promotes the infiltration of CD8+ T cells into the tumor microenvironment, thereby enhancing immunotherapy by PD1 blockade. Mechanistically, PVT1 inhibition stimulates the DNA damage response, which induces CD8+ T cell-recruiting chemokines, while preventing CSCs and metastasis via regulating the miR-375/YAP1 axis. In conclusion, targeting PVT1 might potentiate the elimination of CSCs via immune checkpoint blockade, prevent metastasis, and inhibit HNSCC growth.
Single-cell RNA sequencing reveals cell landscape following antimony exposure during spermatogenesis in Drosophila testes
Authors: Yu Jun , Fu Yangbo , Li Zhiran , Huang Qiuru , Tang Juan , Sun Chi , Zhou Peiyao , He Lei , Sun Feiteng , Cheng Xinmeng , Ji Li , Yu Hao , Shi Yi , Gu Zhifeng , Sun Fei , Zhao Xinyuan 
Published: March 2023

AbstractAntimony (Sb), is thought to induce testicular toxicity, although this remains controversial. This study investigated the effects of Sb exposure during spermatogenesis in theDrosophilatestis and the underlying transcriptional regulatory mechanism at single-cell resolution. Firstly, we found that flies exposed to Sb for 10 days led to dose-dependent reproductive toxicity during spermatogenesis. Protein expression and RNA levels were measured by immunofluorescence and quantitative real-time PCR (qRT-PCR). Single-cell RNA sequencing (scRNA-seq) was performed to characterize testicular cell composition and identify the transcriptional regulatory network after Sb exposure inDrosophilatestes. scRNA-seq analysis revealed that Sb exposure influenced various testicular cell populations, especially in GSCs_to_Early_Spermatogonia and Spermatids clusters. Importantly, carbon metabolism was involved in GSCs/early spermatogonia maintenance and positively related with SCP-Containing Proteins, S-LAPs, and Mst84D signatures. Moreover, Seminal Fluid Proteins, Mst57D, and Serpin signatures were highly positively correlated with spermatid maturation. Pseudotime trajectory analysis revealed three novel states for the complexity of germ cell differentiation, and many novel genes (e.g., Dup98B) were found to be expressed in state-biased manners during spermatogenesis. Collectively, this study indicates that Sb exposure negatively impacts GSC maintenance and spermatid elongation, damaging spermatogenesis homeostasis via multiple signatures inDrosophilatestes and therefore supporting Sb-mediated testicular toxicity.
SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity
Authors: Jaycox Jillian R. , Lucas Carolina , Yildirim Inci , Dai Yile , Wang Eric Y. , Monteiro Valter , Lord Sandra , Carlin Jeffrey , Kita Mariko , Buckner Jane H. , Ma Shuangge , Campbell Melissa , Ko Albert , Omer Saad , Lucas Carrie L. , Speake Cate , Iwasaki Akiko , Ring Aaron M. 
Published: March 2023

AbstractmRNA-based vaccines dramatically reduce the occurrence and severity of COVID-19, but are associated with rare vaccine-related adverse effects. These toxicities, coupled with observations that SARS-CoV-2 infection is associated with autoantibody development, raise questions whether COVID-19 vaccines may also promote the development of autoantibodies, particularly in autoimmune patients. Here we used Rapid Extracellular Antigen Profiling to characterize self- and viral-directed humoral responses after SARS-CoV-2 mRNA vaccination in 145 healthy individuals, 38 patients with autoimmune diseases, and 8 patients with mRNA vaccine-associated myocarditis. We confirm that most individuals generated robust virus-specific antibody responses post vaccination, but that the quality of this response is impaired in autoimmune patients on certain modes of immunosuppression. Autoantibody dynamics are remarkably stable in all vaccinated patients compared to COVID-19 patients that exhibit an increased prevalence of new autoantibody reactivities. Patients with vaccine-associated myocarditis do not have increased autoantibody reactivities relative to controls. In summary, our findings indicate that mRNA vaccines decouple SARS-CoV-2 immunity from autoantibody responses observed during acute COVID-19.
N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model
Authors: Suzzi Stefano , Croese Tommaso , Ravid Adi , Gold Or , Clark Abbe R. , Medina Sedi , Kitsberg Daniel , Adam Miriam , Vernon Katherine A. , Kohnert Eva , Shapira Inbar , Malitsky Sergey , Itkin Maxim , Brandis Alexander , Mehlman Tevie , Salame Tomer M. , Colaiuta Sarah P. , Cahalon Liora , Slyper Michal , Greka Anna , Habib Naomi , Schwartz Michal 
Published: March 2023

AbstractSystemic immunity supports lifelong brain function. Obesity posits a chronic burden on systemic immunity. Independently, obesity was shown as a risk factor for Alzheimer’s disease (AD). Here we show that high-fat obesogenic diet accelerated recognition-memory impairment in an AD mouse model (5xFAD). In obese 5xFAD mice, hippocampal cells displayed only minor diet-related transcriptional changes, whereas the splenic immune landscape exhibited aging-like CD4+ T-cell deregulation. Following plasma metabolite profiling, we identified free N-acetylneuraminic acid (NANA), the predominant sialic acid, as the metabolite linking recognition-memory impairment to increased splenic immune-suppressive cells in mice. Single-nucleus RNA-sequencing revealed mouse visceral adipose macrophages as a potential source of NANA. In vitro, NANA reduced CD4+ T-cell proliferation, tested in both mouse and human. In vivo, NANA administration to standard diet-fed mice recapitulated high-fat diet effects on CD4+ T cells and accelerated recognition-memory impairment in 5xFAD mice. We suggest that obesity accelerates disease manifestation in a mouse model of AD via systemic immune exhaustion.
Naked metallic skin for homo-epitaxial deposition in lithium metal batteries
Authors: Baek Minsung , Kim Jinyoung , Jeong Kwanghoon , Yang Seonmo , Kim Heejin , Lee Jimin , Kim Minkwan , Kim Ki Jae , Choi Jang Wook 
Published: March 2023

AbstractRegulating the morphology of lithium plating is the key to extending the cycle life of lithium metal batteries. Fatal dendritic growth is closely related to out-of-plane nucleation on the lithium metal surface. Herein, we report a nearly perfect lattice match between the lithium metal foil and lithium deposits by removing the native oxide layer using simple bromine-based acid-base chemistry. The naked lithium surface induces homo-epitaxial lithium plating with columnar morphologies and lower overpotentials. Using the naked lithium foil, the lithium-lithium symmetric cell maintains stable cycling at 10 mA cm−2 for more than 10,000 cycles, and the full-cell paired with LiFePO4 with high areal capacity of 3.3 mAh cm−2 and practical N/P ratio of 2.5 exhibits 86% capacity retention after 300 cycles. This study elucidates the usefulness of controlling the initial surface state to facilitate homo-epitaxial lithium plating for sustainable cycling of lithium metal batteries.