bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stroke resource utilisation and all-cause mortality in Thailand 2017–2020: A retrospective, cross-sectional study
Authors: Kumluang Suthasinee , Wu Olivia , Langhorne Peter , Geue Claudia 
Published: June 2023

ObjectiveTo determine resource utilisation, costs and all-cause mortality related to stroke in Thailand.DesignRetrospective, cross-sectional study.Setting and participantsPatients with first-ever stroke in the Thai national claims database between 2017 and 2020 were included for analysis. No individuals were involved.MethodsWe estimated annual treatment costs using two-part models. Survival analysis for all-cause mortality was performed.ResultsWe identified 386 484 patients with incident stroke of which 56% were men. Mean age was 65 years and ischaemic stroke was the most common subtype. Mean annual cost per patient was 37 179 Thai Baht (95% CI: 36 988 to 37 370). Haemorrhagic stroke was predominantly observed in the youngest age groups with the highest estimated mean annual cost. Patients with haemorrhagic stroke also had a longer length of stay (LOS) in hospital and an increased risk of mortality. Key cost drivers were identified to be age, LOS, comorbidity and thrombolysis. Costs were lower in patients who received rehabilitation; however, only 32% of patients received rehabilitation services. The 4-year survival rate of all stroke types was 66.5% (95% CI: 64.3% to 66.7%). Older age, high comorbidity score, long LOS and being treated outside the Bangkok area were factors associated with significantly increased mortality risk, while receiving thrombolysis or rehabilitation was associated with a decreased risk of death.ConclusionThe highest mean cost per patient was found in patients with haemorrhagic stroke. Receiving rehabilitation was associated with lower cost and mortality risk. Rehabilitation and disability outcomes should be improved to ensure an enhancement of health outcomes and efficient use of resources.
Qualitative study of international key informants’ perspectives on the current and future state of healthcare quality measurement and feedback
Authors: Donnelly Candice , Janssen Anna , Shah Kavisha , Harnett Paul , Vinod Shalini , Shaw Tim J 
Published: June 2023

ObjectivesThe aim of this study is to explore the current and future state of quality measurement and feedback and identify factors influencing measurement feedback systems, including the barriers and enablers to their effective design, implementation, use and translation into quality improvement.DesignThis qualitative study used semistructured interviews with key informants. A deductive framework analysis was conducted to code transcripts to the Theoretical Domains Framework (TDF). An inductive analysis was used to produce subthemes and belief statements within each TDF domain.SettingAll interviews were conducted by videoconference and audio-recorded.ParticipantsKey informants were purposively sampled experts in quality measurement and feedback, including clinical (n=5), government (n=5), research (n=4) and health service leaders (n=3) from Australia (n=7), the USA (n=4), the UK (n=2), Canada (n=2) and Sweden (n=2).ResultsA total of 17 key informants participated in the study. The interview length ranged from 48 to 66 min. 12 theoretical domains populated by 38 subthemes were identified as relevant to measurement feedback systems. The most populous domains includedenvironmental context and resources,memory, attention and decision-making, andsocial influences. The most populous subthemes included ‘quality improvement culture’, ‘financial and human resource support’ and ‘patient-centred measurement’. There were minimal conflicting beliefs outside of ‘data quality and completeness’. Conflicting beliefs in these subthemes were predominantly between government and clinical leaders.ConclusionsMultiple factors were found to influence measurement feedback systems and future considerations are presented within this manuscript. The barriers and enablers that impact these systems are complex. While there are some clear modifiable factors in the design of measurement and feedback processes, influential factors described by key informants were largely socioenvironmental. Evidence-based design and implementation, coupled with a deeper understanding of the implementation context, may lead to enhanced quality measurement feedback systems and ultimately improved care delivery and patient outcomes.
Patient and public involvement in emergency care research: a scoping review of the literature
Authors: Muir Rachel , Carlini Joan , Crilly Julia , Ranse Jamie 
Published: June 2023

BackgroundEstablishing the benefits of patient and public involvement (PPI) in emergency care research is important to improve the quality and relevance of research. Little is known about the extent of PPI in emergency care research, its methodological and reporting quality. This scoping review aimed to establish the extent of PPI in emergency care research, identify PPI strategies and processes and assess the quality of reporting on PPI in emergency care research.MethodsKeyword searches of five databases (OVID MEDLINE, Elsevier EMBASE, EBSCO CINAHL, PsychInfo, Cochrane Central Register of Controlled trials); hand searches of 12 specialist journals and citation searches of the included journal articles were performed. A patient representative contributed to research design and co-authored this review.ResultsA total of 28 studies reporting PPI from the USA, Canada, UK, Australia and Ghana were included. The quality of reporting was variable, with only seven studies satisfying all Guidance for Reporting Involvement of Patients and the Public short form reporting criteria. None of the included studies adequately described all the key aspects of reporting the impact of PPI.ConclusionRelatively few emergency care studies comprehensively describe PPI. Opportunity exists to improve the consistency and quality of reporting of PPI in emergency care research. Further research is required to better understand the specific challenges for implementing PPI in emergency care research, and to determine whether emergency care researchers have adequate resources, education and funding to undertake and report involvement.
Data from Comutations and KRAS<sup>G12C</sup> Inhibitor Efficacy in Advanced NSCLC
Authors: Negrao Marcelo V. , Araujo Haniel A. , Lamberti Giuseppe , Cooper Alissa J. , Akhave Neal S. , Zhou Teng , Delasos Lukas , Hicks J. Kevin , Aldea Mihaela , Minuti Gabriele , Hines Jacobi , Aredo Jacqueline V. , Dennis Michael J. , Chakrabarti Turja , Scott Susan C. , Bironzo Paolo , Scheffler Matthias , Christopoulos Petros , Stenzinger Albrecht , Riess Jonathan W. , Kim So Yeon , Goldberg Sarah B. , Li Mingjia , Wang Qi , Qing Yun , Ni Ying , Do Minh Truong , Lee Richard , Ricciuti Biagio , Alessi Joao Victor , Wang Jing , Resuli Blerina , Landi Lorenza , Tseng Shu-Chi , Nishino Mizuki , Digumarthy Subba R. , Rinsurongkawong Waree , Rinsurongkawong Vadeerat , Vaporciyan Ara A. , Blumenschein George R. , Zhang Jianjun , Owen Dwight H. , Blakely Collin M. , Mountzios Giannis , Shu Catherine A. , Bestvina Christine M. , Garassino Marina Chiara , Marrone Kristen A. , Gray Jhanelle E. , Patel Sandip Pravin , Cummings Amy L. , Wakelee Heather A. , Wolf Juergen , Scagliotti Giorgio Vittorio , Cappuzzo Federico , Barlesi Fabrice , Patil Pradnya D. , Drusbosky Leylah , Gibbons Don L. , Meric-Bernstam Funda , Lee J. Jack , Heymach John V. , Hong David S. , Heist Rebecca S. , Awad Mark M. , Skoulidis Ferdinandos 
Published: June 2023

<div>Abstract<p>Molecular modifiers of KRAS<sup>G12C</sup> inhibitor (KRAS<sup>G12Ci</sup>) efficacy in advanced <i>KRAS</i><sup>G12C</sup>-mutant NSCLC are poorly defined. In a large unbiased clinicogenomic analysis of 424 patients with non–small cell lung cancer (NSCLC), we identified and validated coalterations in <i>KEAP1, SMARCA4</i>, and <i>CDKN2A</i> as major independent determinants of inferior clinical outcomes with KRAS<sup>G12Ci</sup> monotherapy. Collectively, comutations in these three tumor suppressor genes segregated patients into distinct prognostic subgroups and captured ∼50% of those with early disease progression (progression-free survival ≤3 months) with KRAS<sup>G12Ci</sup>. Pathway-level integration of less prevalent coalterations in functionally related genes nominated PI3K/AKT/MTOR pathway and additional baseline <i>RAS</i> gene alterations, including amplifications, as candidate drivers of inferior outcomes with KRAS<sup>G12Ci</sup>, and revealed a possible association between defective DNA damage response/repair and improved KRAS<sup>G12Ci</sup> efficacy. Our findings propose a framework for patient stratification and clinical outcome prediction in <i>KRAS</i><sup>G12C</sup>-mutant NSCLC that can inform rational selection and appropriate tailoring of emerging combination therapies.</p>Significance:<p>In this work, we identify co-occurring genomic alterations in <i>KEAP1</i>, <i>SMARCA4</i>, and <i>CDKN2A</i> as independent determinants of poor clinical outcomes with KRAS<sup>G12Ci</sup> monotherapy in advanced NSCLC, and we propose a framework for patient stratification and treatment personalization based on the comutational status of individual tumors.</p></div>
Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of the Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential
Authors: Sans Marta , Makino Yuki , Min Jimin , Rajapakshe Kimal I. , Yip-Schneider Michele , Schmidt C. Max , Hurd Mark W. , Burks Jared K. , Gomez Javier A. , Thege Fredrik I. , Fahrmann Johannes F. , Wolff Robert A. , Kim Michael P. , Guerrero Paola A. , Maitra Anirban 
Published: June 2023

Abstract

Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are bona fide precursor lesions of pancreatic ductal adenocarcinoma (PDAC). The most common subtype of IPMNs harbors a gastric foveolar-type epithelium, and these low-grade mucinous neoplasms are harbingers of IPMNs with high-grade dysplasia and cancer. The molecular underpinning of gastric differentiation in IPMNs is unknown, although identifying drivers of this indolent phenotype might enable opportunities for intercepting progression to high-grade IPMN and cancer. We conducted spatial transcriptomics on a cohort of IPMNs, followed by orthogonal and cross-species validation studies, which established the transcription factor NKX6-2 as a key determinant of gastric cell identity in low-grade IPMNs. Loss of NKX6-2 expression is a consistent feature of IPMN progression, while reexpression of Nkx6-2 in murine IPMN lines recapitulates the aforementioned gastric transcriptional program and glandular morphology. Our study identifies NKX6-2 as a previously unknown transcription factor driving indolent gastric differentiation in IPMN pathogenesis.

Significance:
Identification of the molecular features driving IPMN development and differentiation is critical to prevent cancer progression and enhance risk stratification. We used spatial profiling to characterize the epithelium and microenvironment of IPMN, which revealed a previously unknown link between NKX6-2 and gastric differentiation, the latter associated with indolent biological potential.
See related commentary by Ben-Shmuel and Scherz-Shouval, p. 1768.
This article is highlighted in the In This Issue feature, p. 1749
Effect of the Directive and Non-directive Inspection Approaches on Teach-er Instructional Effectiveness in Government- aided Primary Schools in Nakisunga County, Uganda
Authors: Ntege Joseph Lubwama , Kasule Geirge Wilson , Owino Phillip , Mugizi Wilson 
Published: June 2023

This study investigated the effect of the directive and non-directive school inspection approaches on teacher instructional effectiveness. While teacher instructional effectiveness was studied in terms of reporting on pupil academic achievements, teacher attitudes, effective planning, attendance and pedagogical approaches, the directive School inspection approach was studied in terms of directing and evaluation of teacher knowledge yet the non-directive approach was studied in terms of team planning and consultations. A cross-sectional survey mixed research design using the quantitative and qualitative approaches on a sample of 178 people namely teachers, head teachers, school inspectors and education officers was adopted. While quantitative data was collected using survey questionnaires and analysed using inferential analysis, qualitative data was collected through interviews, focus group discussions and analysed by grouping the responses in themes which were merged with quantitative findings. The findings showed that all the attributes of directive inspection approach were positively insignificant to teacher instructional effectiveness explaining that they had no impact on teacher instructional effectiveness. Similarly, team planning had a positive and insignificant relationship meaning that it had no effect on teacher instructional effectiveness. In conclusion, only team planning had effect on teacher instructional effectiveness and consultation did not have any effect. It was recommended that school inspectors should use the non-directive inspection approach because of sub-variable team planning that had a positive effect on teacher instructional effectiveness.
A Personal Narrative Experience of Teachers Teaching Purposive Commu-nication During the New Normal Education
Authors: Salendab Fahad Abdul , Akmad Saiden Panggo 
Published: June 2023

This study explored the teachers’ teaching experiences in purposive communication during the new normal education setup at Sultan Kudarat State University-Kalamansig Campus. Qualitative research design using the narrative research methods was the research design of this study. It used non-probability purposive sampling as the sampling technique. There were five (5) teachers handling purposive communication. Moreover, this study employed a semi-structured interview guide with open-ended questions. The data were analyzed using Colizzi’s thematic analysis.
The teachers' experiences teaching purposive communication seem fruitful and efficient for students learning. Classes were conducted using the blended learning approach. Due to internet connectivity issues, Asynchronous was the typical learning mode than synchronous session. Further, the learning assessment was found to be unauthentic because it was conducted using asynchronous mode. Internet connectivity and power interruptions were the greatest challenges ever experienced by the teachers. Their coping mechanism included psychological health and well-being and proactive and approach-oriented application. The use of a personal budget is also included.
It is concluded that teachers have issues in lesson planning, classroom management, internet connectivity, and managing students' virtual behavior in the new normal environment. Teachers have utilized a variety of strategies to overcome difficulties.
It is recommended that the institution should provide planning programs as a foundation for new normal teaching and perform a series of studies on instructors' experiences in the new normal educational scheme. The faculty should evaluate the practicability of their teaching methods to satisfy the needs of students with diverse cultures during the new normal.
High degree of independence in the feeding apparatus of planarian flatworms
Authors: Wu Ming-Qi , Liu Hai-Long , Xia Meng-Yu , Zhang Yu , Sluys Ronald , Wang An-Tai 
Published: June 2023

Abstract
In this contribution, feeding behaviour assays with the three species Paucumara falcata, Dugesia sp. and Girardia sp. were used to investigate the function of the pharynx during feeding and whether absence of feeding behaviour until full regeneration is a widespread phenomenon among planarians from different taxonomic groups. Our results showed that feeding behaviour of decapitated flatworms was inhibited. Intact worms responded only to pork liver pieces, but isolated pharynges were highly responsive to both pork liver pieces and pork liver extracts. After transverse cutting, the oral part of the isolated pharynx was responsive, while the aboral part showed no response to food items, suggesting that the oral portion of pharynx plays a crucial role during feeding.
Hugo Grotius’s De iure belli ac pacis: Henricus Laurentius’ Re-Issue (1647) of the 1631 Edition
Authors: Cleary Matthew , Corredera Edward Jones , Dufour Pablo Nicolas , Nathan Jonathan , Salerno Emanuele , Somos Mark 
Published: June 2023

Abstract
This research note is the eighth instalment in our series of preliminary findings on the census and study of the reception of De iure belli ac pacis. The note presents a bibliographical description of Laurentius’ 1647 re-issue of the 1631 edition by Blaeu, considers Laurentius’ motivation and methods of production, lists and maps the currently known twenty-three surviving copies, and briefly describes two notable exemplars.
Co-producing ideas, leaders and learning – teaching participatory activism in Stoke-on-Trent
Authors: Goldstraw Katy 
Published: June 2023

This paper will critically analyse a University-funded Centre of Learning and Pedagogic Practice (SCoLPP) project. The project was designed to integrate the co-produced learning from the Action on Poverty and Hardship Degree steering group, which was made up of local and national Voluntary and Community Sector (VCS) leaders and low-income students on the course. The project was directly aligned with the University Academic Strategy, designed to integrate academic integrity into innovative curriculum design. This article will critically discuss how the project, in its co-produced place-based approach, aligned its curriculum design to external engagement within Stoke-on-Trent. The Action on Poverty and Hardship Degree team worked over the course of 18 months with a steering group of local and national voluntary sector employers to actively recruit and support students from low-income backgrounds to become engaged in anti-poverty activism. This article will critically discuss how the voices of students with lived experience of poverty engaged to co-produce learning with local and national voluntary sector leaders. The paper will critically reflect on best practice in co-produced curriculum development.
Governing by entrepreneurship: Entrepreneurial ecosystems and socio-spatial difference
Authors: Hartman Julian B , Kear Mark T 
Published: June 2023

Literature on entrepreneurial ecosystems (EEs) has grown rapidly over the past 5 years, using the concept as a framework to understand regional clusters of entrepreneurship. This article reviews, critiques, and extends the concept of the EE, arguing for its relevance in studying the political economy of urban space. To make this argument, we distinguish between niche EEs (NEEs) and growth EEs (GEEs). This distinction is based on the overlapping but distinct networks of actors and institutions forming each type of EE and also reflects broadly different relationships to growth and productivity, the entrepreneurial subject, global and local scales, and financial ecologies. We argue that EE research has largely focused on GEEs to the neglect of NEEs; by broadening the EE concept, we address shortcomings in the treatment of small businesses, financial relations, social difference, as well as urban politics within the EE literature. Drawing on the EE literature and interviews from a case study of Boston, we show that the infrastructure of GEEs and NEEs are not only “for” fast- and slow-growing businesses, respectively, but reinforce social and economic differences. While NEEs do redistribute resources to marginalized entrepreneurs, these resources are focused on building businesses and only indirectly related to the needs of marginalized communities and equitable development more generally.
Clinical Outcomes of Indigenous Versus Non-Indigenous Patients: A Multicenter Retrospective Cohort Study in the Province of Quebec
Authors: Diendéré Ella , Turgeon Alexis F. , Gagnon-Labelle Katherine , Couture Amélie , Neveu Xavier , St-Onge Maude 
Published: June 2023

Introduction: Canadian Indigenous populations have a high incidence of poisoning; it has been suggested that care provided to the population living in remote areas is suboptimal. Our study aims to compare the continuum of care of poisoned people in Indigenous communities with those in non-Indigenous communities located in rural regions in the province of Québec. Methods: We conducted a multicenter retrospective cohort study using data from the Center Antipoison du Québec (CAPQ) over a 2-year period (2016-2017). We evaluated the care trajectory of Indigenous patients suffering of poisoning as compared to non-Indigenous patients living in rural areas. Our primary outcome was the duration of CAPQ involvement in case management. Our secondary outcome was the symptoms severity at the end of case management. Results: Among 491 identified poisoned patients (238 Indigenous/253 non-Indigenous), the duration of CAPQ involvement in case management was 9.4 h [2.9-21.3] for Indigenous patients versus 5.5 h [0.1-14.4] for non-Indigenous patients. No statistically significant difference was found between groups (geometric means ratio (GMR) adjusted = 1.08; [0.84; 1.38]). Results were consistent by age and sex groups. Most patients, in both Indigenous and non-Indigenous, showed mild to moderate symptoms at follow-up (59% vs 54%). One death was registered in each group. The CAPQ received a limited number of calls from the non-conventioned First Nations during the study period. Conclusions: We did not observe differences on the duration in case management. Perceptions of suboptimal care provided to rural Indigenous population are likely to be related to geographical remoteness rather than ethnicity. Further research is needed to better identify potential factors involved in the continuity of care provided in emergency situations. Another study will be carried out to describe the Indigenous realities and to better understand the results of this study.
Bakakinite, Ca2V2O7, a new mineral from fumarolic exhalations of the Tolbachik volcano, Kamchatka, Russia
Authors: Pekov Igor V. , Agakhanov Atali A. , Koshlyakova Natalia N. , Zubkova Natalia V. , Yapaskurt Vasiliy O. , Britvin Sergey N. , Vigasina Marina F. , Turchkova Anna G. , Nazarova Maria A. 
Published: June 2023

AbstractThe new mineral bakakinite, ideally Ca2V2O7, was found in the high-temperature (not lower than 500°C) exhalations of the Arsenatnaya fumarole at the Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka, Russia. It is associated with anhydrite, svabite, pliniusite, schäferite, berzeliite, diopside, hematite, powellite, baryte, fluorapatite, calciojohillerite, ludwigite, magnesioferrite, anorthite, titanite and esseneite. Bakakinite forms flattened crystals up to 30 × 5 μm, typically distorted. The mineral is transparent, colourless or pale yellow, with strong vitreous lustre. Electron microprobe analysis gave (wt.%): CaO 37.04, SrO 0.26, SiO2 0.16, P2O5 1.48, V2O5 49.47, As2O5 10.85, SO3 0.35, total 99.61. The empirical formula calculated on the basis of 7 O apfu is (Ca1.99Sr0.01)Σ2.00(V1.64As0.28P0.06Si0.01S0.01)Σ2.00O7. The Dcalc is 3.463 g cm–3. Bakakinite is triclinic, P$\bar{1}$, unit-cell parameters are: a = 6.64(2), b = 6.92(2), c = 7.01(2) Å, α = 86.59(7), β = 63.77(7), γ = 83.47(6)°, V = 287.0(5) Å3 and Z = 2. The strongest reflections of the powder X-ray diffraction pattern [d,Å(I)(hkl)] are: 4.647(27)(111, 0$\bar{1}$1), 3.138(76)(002), 3.103(100)(120, 121), 3.027(20)(021), 2.960(81)(200), 2.158(19)(031, 302), 1.791(16)(320), 1.682(16)(114) and 1.584(17)(1$\bar{3}$3, 403). Bakakinite is a natural analogue of synthetic Ca2V2O7. The mineral is named in honour of the outstanding Russian crystallographer and crystal chemist Vladimir Vasilievich Bakakin (born 1933).