bluuebunny/crossref_metadata_2025_split huggingface dataset:
The perception of pediatric sickle cell anemia patient's caregivers toward hematopoietic stem cell transplantation (single-center experience, Saudi Arabia)
Authors: Monagel Dania A. , Alemam Naglla , Betar Manar , Alnafisi Fay N. , Faidah Dania E. , Aloteibi Reema E. , Khan Muhammad , Malli Israa A. 
Published: May 2023

BackgroundSickle cell disease (SCD) is a relatively common genetic disorder in Saudi Arabia characterized by the predominance of sickle hemoglobin (HbS). Although multiple supportive care options exist for patients with SCD, hematopoietic stem cell transplantation (HSCT) is the only cure available and has become highly successful, with an almost 91% overall survival rate. However, pursuing this procedure is still restrained as a curative treatment option. Therefore, this study aimed to evaluate the perception of parents' caregivers at the National Guard Hospital pediatric hematology clinic regarding using HSCT as a curative approach for their children with SCD.MethodsThis is a cross-sectional study of the interviewer-administered survey distributed utilizing electronic devices to caregivers of pediatric patients with SCD. Subjects were recruited from Pediatric Hematology &amp; Oncology clinics at National Guard Hospital Affairs in King Abdulaziz Medical City, Jeddah, Saudi Arabia. An estimated sample size of 100 was initially calculated out of 140 pediatric SCD patients; 72 responses were collected from participants. All study participants gave informed consent. All results were analyzed using SPSS; moreover, statistics were set at a CI of 95% and a p &lt; 0.05. In addition, inferential and descriptive statistics were done.ResultsOf all respondents, 42 (67.8%) would accept HSCT if their hematologist recommended it. However, approximately 7 (11.3%) were not interested in the procedure, and the rest, 13 (21%), were uncertain. The most reported reasons for HSCT rejection among all respondents were attributed to side effects 31 (50.8%), lack of knowledge 8 (13.1%), and misconception toward the procedure 22 (36.1%).ConclusionThe results of this study were consistent with the fact that most caregivers would follow along with HSCT if it seemed to be fit and was recommended by their hematologists. However, to the best of our knowledge, our study being the first of its kind in the region, further research in the kingdom on the perception of HSCT is needed. Nonetheless, further patient education, an increase in caregivers' knowledge, and enlightenment of the medical team on HSCT as a curative option for sickle cell disease are vital.
Ripretinib in combination with tyrosine kinase inhibitor as a late-line treatment option for refractory gastrointestinal stromal tumors: two case reports and literature review
Authors: Zhang Yefan , Huang Zhen 
Published: May 2023

Background: This case report presents two clinical cases of metastatic refractory gastrointestinal stromal tumor (GIST) with treatment history of 6–14 years. The follow-up treatment of both cases comprised ripretinib dose escalation and its combination with other tyrosine kinase inhibitors (TKIs). To the best of our knowledge, this is the first report that explored ripretinib combination therapy in the late-line treatment of GISTs.Case description: Case-1 represents a 57-year-old female patient who underwent surgical resection for retroperitoneal GIST in 2008. After tumor recurrence in 2009, imatinib was started with complete response for 8 years. Imatinib was followed by sunitinib and regorafenib treatment. In March 2021, due to progressive disease (PD), the patient started ripretinib (150 mg QD) and achieved partial response (PR). Six months later, the patient showed PD. Subsequently, ripretinib dose was increased (150 mg BID) followed by ripretinib (100 mg QD) and imatinib (200 mg QD) combination. CT performed in February 2022 revealed stable lesions with internal visible necrosis. Combination therapy achieved stable disease (SD) for 7 months. On further follow-up in July 2022, the patient showed PD and died in September 2022.Case-2: represents a 73-year-old female patient diagnosed with unresectable duodenal GIST with liver, lung, and lymph node metastases in 2016. After treatment with imatinib, followed by sunitinib, regorafenib, and imatinib rechallenge, ripretinib (150 mg QD) was administered in May 2021, and SD was achieved. Ripretinib dose was increased (200 mg QD) due to PD in December 2021. The tumor showed heterogeneous manifestations, with overall size increase and regression in right posterior lobe. In February 2022, ripretinib (150 mg) plus sunitinib (25 mg) QD was commenced. On follow-up in April 2022, the patient showed slightly improved symptoms with stable hematologic parameters. Combination therapy achieved SD for 5 months and the patient showed PD in July 2022 and discontinued the treatment later. The patient was in poor general condition and was receiving nutritional therapy until last follow-up in October 2022.Conclusion: This case report provides evidence that combination therapy of ripretinib with other TKIs could be an effective late-line treatment option for refractory GIST patients.
Morphologic and genic effects of waste pollution on the reproductive physiology of Paracentrotus lividus lmk: a mesocosm experiment
Authors: Glaviano Francesca , Federico Serena , Pinto Bruno , Gharbi Maissa , Russo Tania , Cosmo Anna Di , Polese Gianluca , Costantini Maria , Zupo Valerio 
Published: May 2023

A considerable amount of coastal contamination is caused by wastes deriving from household and the degradation and the metabolism of plants and animals, even if our attention is commonly focused on industrial pollutants and contaminants. Waste pollutants are mainly represented by highly diluted soluble compounds and particles deriving from dead organisms. This complex combination, consisting of suspended particles and dissolved nutrients, has a significant impact on coastal planktonic and benthic organisms, also playing an active role in the global cycles of carbon. In addition, production practices are nowadays shifting towards recirculated aquaculture systems (RAS) and the genic responses of target organisms to the pollution deriving from animal metabolism are still scarcely addressed by scientific investigations. The reservoir of organic matter dissolved in the seawater is by far the least understood if compared to that on land, cause only a few compounds have been identified and their impacts on animals and plants are poorly understood. The tendency of these compounds to concentrate at interfaces facilitates the absorption of dissolved organic compound (DOC) onto suspended particles. Some DOC components are chemically combined with dissolved metals and form complexes, affecting the chemical properties of the seawater and the life of the coastal biota. In this research, we compared the reproductive performances of the common sea urchin Paracentrotus lividus cultured in open-cycle tanks to those cultured in a recirculating aquaculture system (RAS), where pollution progressively increased during the experiment due to animal escretions. Sea urchins were cultured for 7 months under these two conditions and their gametes were collected. Embryos resulting by in vitro fertilization were analyzed by Real Time qPCR to identify possible effects of pollution-induced stress. The fertility of sea urchins was evaluated, as well as the gonadosomatic indices and the histological features of gonads. Our results indicate that pollution due to excess of nutrients, event at sub-lethal concentrations, may hardly impact the reproductive potential of this key species and that chronic effects of stress are revealed by the analyses of survival rates and gene expression.
Exploring the neurobiology of Merge at a basic level: insights from a novel artificial grammar paradigm
Authors: Liu Yang , Gao Chenyang , Wang Peng , Friederici Angela D. , Zaccarella Emiliano , Chen Luyao 
Published: May 2023

IntroductionHuman language allows us to generate an infinite number of linguistic expressions. It’s proposed that this competence is based on a binary syntactic operation, Merge, combining two elements to form a new constituent. An increasing number of recent studies have shifted from complex syntactic structures to two-word constructions to investigate the neural representation of this operation at the most basic level.MethodsThis fMRI study aimed to develop a highly flexible artificial grammar paradigm for testing the neurobiology of human syntax at a basic level. During scanning, participants had to apply abstract syntactic rules to assess whether a given two-word artificial phrase could be further merged with a third word. To control for lower-level template-matching and working memory strategies, an additional non-mergeable word-list task was set up.ResultsBehavioral data indicated that participants complied with the experiment. Whole brain and region of interest (ROI) analyses were performed under the contrast of “structure &gt; word-list.” Whole brain analysis confirmed significant involvement of the posterior inferior frontal gyrus [pIFG, corresponding to Brodmann area (BA) 44]. Furthermore, both the signal intensity in Broca’s area and the behavioral performance showed significant correlations with natural language performance in the same participants. ROI analysis within the language atlas and anatomically defined Broca’s area revealed that only the pIFG was reliably activated.DiscussionTaken together, these results support the notion that Broca’s area, particularly BA 44, works as a combinatorial engine where words are merged together according to syntactic information. Furthermore, this study suggests that the present artificial grammar may serve as promising material for investigating the neurobiological basis of syntax, fostering future cross-species studies.
Deep space debris—Detection of potentially hazardous asteroids and objects from the southern hemisphere
Authors: Kruzins Ed , Benner Lance , Boyce Russell , Brown Melrose , Coward David , Darwell Sam , Edwards Phil , Elizabeth-Glina Lauren , Giorgini Jon , Horiuchi Shinji , Lambert Andrew , Lazio Joseph , Calves Guifre Molera , Moore John , Peters Edwin , Phillips Chris , Stevens Jamie , Verveer Arie 
Published: May 2023

Space debris are composed of both natural and human made objects, some in near Earth orbits while others are passing through deep space. Asteroids may represent one form of near Earth and deep space debris. In this article we report on a set of asteroid observations from the southern hemisphere. We indicate that Apollo and Aten class asteroids represent another form of deep space debris of a potentially hazardous nature to orbiting spacecraft and/or Earth based locations. We also show some of the operational challenges, types of facilities and the importance of geographic diversity, that is, necessary for detecting, observing and characterising asteroids, especially PHA’s. For many years, space agencies and institutions have observed and monitored near Earth asteroids and objects (NEO’s) using high gain radio frequency antennas and optical telescopes in the northern hemisphere (GSSR, Arecibo, Catalina, Pan-STARRS, Atlas and Linear) 1) However a regular operational system to monitor the southern skies does not have the same level of maturity and is where a percentage of asteroids and various human made objects are not detected until they pass into northern skies. To fill that gap the Southern Hemisphere Asteroid Radar Program (SHARP) 2) located in Australia uses available antenna time on either a 70 or 34 m beam waveguide antenna located at the Canberra Deep Space Communication Complex (CDSCC) to transmit a Doppler compensated continuous radio wave at 2.114 GHz (14.2 cm) and 7.15945 GHz (4.2 cm) toward the NEO and receive its echoes at the 64 m Parkes or 6 m × 22 m Australia Telescope Compact Array (ATCA) antennas at Narrabri in Australia. This mode of NEO observation is termed a deep space bistatic radar. The southern hemisphere program has also recently been joined by the 12 m University of Tasmania antennas at Hobart (Tasmania) and Katherine (Northern Territory). Combining SHARPS bistatic radar with small optical apertures located at the University of New South Wales (UNSW) and University of Western Australia (UWA) allows combined optical/RF NEO detections. Whilst sub-metre class optical instruments have contributed independently to asteroid detection over decades, the use of coordinated small 0.3–0.5 m instruments synchronized to large asteroid radars offers an observational flexibility and adaptability when larger optical systems 3) are dedicated to other forms of professional optical astronomy. Since 2015, SHARP has illuminated and tracked over 30 NEO’s ranging in diameter from 7 to 5000 m at ranges of 0.1–18 lunar distances (LD) from Australia.
Re-expansion of vertebral compression fractures in patients with multiple myeloma with percutaneous vertebroplasty using spinejack implants: a preliminary and retrospective study
Authors: Pusceddu Claudio , Faiella Eliodoro , Derudas Daniele , Ballicu Nicola , Melis Luca , Zedda Stefano , Marsico Salvatore 
Published: May 2023

ObjectiveTo retrospectively evaluate the feasibility and effectiveness of vertebroplasty using Spinejack implantation for the treatment and stabilization of painful vertebral compression fractures, in patients diagnosed with Multiple Myeloma (MM), to allow both an effective pain reduction and a global structural spine stabilization.Materials and MethodsFrom July 2017 and May 2022 thirty-nine patients diagnosed MM, with forty-nine vertebral compression fractures underwent percutaneous Vertebroplasty using Spinejack Implants. We analyzed the feasibility and complications of the procedure, the decrease in pain using visual analogue scale (VAS) and Functional Mobility Scale (FMS).ResultsThe technical success rate was 100%. No procedure-related major complications or death occurred. In the 6-month follow-up, the mean VAS score decreased from 5.4 ± 1.0 to 0.2 ± 0.5 with a mean reduction of 96.3%. FMS decreased from 2.3 ± 0.5 vs. 1.2 ± 0.4 with a mean reduction of −47.8%. There were no major complications related to incorrect positioning of the Expandable Titanium SpineJack Implants. In five patients, a cement leak was observed with no associated clinical manifestations. The average length of hospital stay was 6–8 Hours6.6 ± 1.2 h. No new bone fractures or local disease recurrence occurred during a median contrast-enhanced CT follow-up of 6 months.ConclusionsOur results suggest that vertebroplasty, using Spinejack implantation for the treatment and stabilization of painful vertebral compression fractures, secondary to Multiple Myeloma is a safe and effective procedure with long - term pain relief and restoration of vertebral height.
Innovation in gastrointestinal surgery: the evolution of minimally invasive surgery—a narrative review
Authors: Walshaw Josephine , Huo Bright , McClean Adam , Gajos Samantha , Kwan Jing Yi , Tomlinson James , Biyani Chandra Shekhar , Dimashki Safaa , Chetter Ian , Yiasemidou Marina 
Published: May 2023

BackgroundMinimally invasive (MI) surgery has revolutionised surgery, becoming the standard of care in many countries around the globe. Observed benefits over traditional open surgery include reduced pain, shorter hospital stay, and decreased recovery time. Gastrointestinal surgery in particular was an early adaptor to both laparoscopic and robotic surgery. Within this review, we provide a comprehensive overview of the evolution of minimally invasive gastrointestinal surgery and a critical outlook on the evidence surrounding its effectiveness and safety.MethodsA literature review was conducted to identify relevant articles for the topic of this review. The literature search was performed using Medical Subject Heading terms on PubMed. The methodology for evidence synthesis was in line with the four steps for narrative reviews outlined in current literature. The key words used were minimally invasive, robotic, laparoscopic colorectal, colon, rectal surgery.ConclusionThe introduction of minimally surgery has revolutionised patient care. Despite the evidence supporting this technique in gastrointestinal surgery, several controversies remain. Here we discuss some of them; the lack of high level evidence regarding the oncological outcomes of TaTME and lack of supporting evidence for robotic colorectalrectal surgery and upper GI surgery. These controversies open pathways for future research opportunities with RCTs focusing on comparing robotic to laparoscopic with different primary outcomes including ergonomics and surgeon comfort.
Correction: Monaco et al. Chiral Phase Transfer Catalysis in the Asymmetric Synthesis of a 3,3-Disubstituted Isoindolinone and Determination of Its Absolute Configuration by VCD Spectroscopy. Molecules 2020, 25, 2272
Authors: Monaco Guglielmo , Tiffner Maximilian , Di Mola Antonia , Herrebout Wouter , Waser Mario , Massa Antonio 
Published: May 2023

In this note, we report a correction to the published article, Molecules 2020, 25, 2272 [...]
Mapeamento e classificação da mancha urbana da cidade de Feira de Santana-BA com uso de imagens SENTINEL-2 e aprendizagem de máquina
Authors: Da Silva Lorena Souza , Peixoto João Paulo Just , Fernandez Basílio , Lima Thyago Anthony Soares , Sampaio Diane de Oliveira , Rosa Marcos Reis , Vasconcelos Rodrigo de Nogueira 
Published: May 2023

Os estudos de áreas urbanas tornam-se cada vez mais importantes com o crescimento populacional vertiginoso e consequentemente o aumento da malha urbana para supri-lo com o aumento de suas populações. Investigar estes locais através do sensoriamento remoto exige não somente o habitual conhecimento do objeto de estudo, mas também o uso de ferramentas estatísticas que apresentem uma validação confiável dos resultados obtidos. Com o objetivo de detectar as mudanças na mancha urbana da cidade de Feira de Santana, BA, este artigo faz uso do algoritmo de aprendizado de máquina Random Forest aplicado a uma coleção de imagens do satélite Sentinel-2 entre 2019 e 2021, para classificar a área construída dentro do perímetro dos bairros da cidade em prédios e residências. O script desenvolvido no Google Earth Engine (GEE) obteve uma acurácia global de 86%, que resulta em uma imagem satisfatória da mancha urbana da cidade.
PENERAPAN TEKNOLOGI ATRACTOR CUMI KEPADA KELOMPOK NELAYAN : UPAYA PENINGKATAN PRODUKTIVITAS PERAIRAN DI TELUK MANADO
Authors: Patty Wilhelmina , Pangalila Fransisco , Ange Irawan 
Published: May 2023

Cumi-cumi merupakan salah satu sumber daya hayati laut yang bernilai ekonomis tinggi. Ketersediaan (supply) telur cumi di perairan sangat berhubungan dengan produktivitas perairan. Telur cumi-cumi dapat dikumpulkan dari alam dengan bantuan atraktor cumi-cumi. Keunggulan dari atraktor cumi-cumi yaitu mampu menampung telur cumi-cumi dan sebagai habitat buatan bagi ikan-ikan kecil sehingga siklus hidup cumi-cumi maupun ikan dapat terjamin. Berbagai metode dan bentuk atractor sudah pernah diteliti dan diterapkan di wilayah perairan Teluk Manado. Untuk itu dalam tulisan ini akan disosialisasikan kepada kelompok nelayan lewat program pengabdian kepada Masyarakat. Kegiatan pengabdian ini juga akan diperkenalkan metode konstruksi dan penerapan atractor ini di dalam perairan, diikuti dengan pengamatan penempelan telur cumi pada atractor tersebut. Kegiatan ini juga merupakan salah satu upaya pemberdayaan nelayan untuk mengenal teknologi yang dapat meningkatkan produktifitas perairan wilayah pesisir yang merupakan fishing ground.

Kata Kunci: Atractor; Cumi; Nelayan; Teluk Manado
Pemenuhan Hak Dipilih dan Hak Memilih sebagai Hak Konstitusional: Studi Komparatif Pasca Putusan Mahkamah Konstitusi
Authors: Budahu Muhammad Abdi Sabri , Kasim Aminuddin , Lasatu Asri , Palilingan Toar Neman 
Published: May 2023

Penelitian ini bertujuan untuk menganalisis penerapan nilai keadilan sebagai dasar pertimbangan Mahkamah Konstitusi No 74/PUU-XVIII/2020 Pengujian Pasal 222 Undang-Undang No 7 Tahun 2017 tentang Pemilihan Umum terkait dengan Legal Standing Pemohon. Penelitian ini merupakan penelitian hukum normatif. Hasil penelitian ini menunjukkan bahwa argumentasi kerugian konstitusional para pemohon seharusnya Mahkamah Konstitusi mempertimbangkan kembali terkait kedudukan hukum para pemohon. Norma ambang batas (presidential threshold) pencalonan Presiden dan Wakil Presiden yang diajukan oleh para pemohon sangat berpotensi menimbulkan kerugian konstitusional. Para pemohon juga secara konkret telah terjadi suatu peristiwa hukum dimana partai-partai baru tidak dapat mencalonkan Presiden dan Wakil Presiden yang disebabkan norma ambang batas Pencalonan Presiden dan Wakil Presiden. Diperlukan pengaturan secara spesifik terkait dengan penentuan kualifikasi legal standing perkara abstrak dan perkara konkret tehadap pemohon dua perkara tersebut agar dapat terwujudnya kepastian hukum dalam permohonan judicial review.
SOSIALISASI MENGENAI DAMPAK DAN BAHAYA BULLYING BAGI ANAK-ANAK SMPN 20 KOTA BENGKULU DAN NARAPIDANA DI LEMBAGA PEMASYARAKATAN KELAS IIB ARGA MAKMUR
Authors: Suryadinata Jaka , Hartati Merri Sri , Ira Yuniati  
Published: May 2023

Program sosialisasi mengenai pengetahuan hukum tentang Bullying adalah untuk memberikan pemahaman tentang pentingnya memahami hukum, mentaati aturan hukum yang berlaku, dan juga menumbuhkan kesadaran diri tentang perlunya menghindari perbuatan Bullying dalam kehidupan sehari-hari. Sasaran dari sosialisasi mengenai bullying ini ditujukan kepada anak-anak SMPN 20 Kota Bengkulu dan narapidana yang ada di Lembaga Pemasyarakatan Kelas IIB Arga Makmur. Metode yang digunakan dalam sosialisasi mengenai bullying yaitu metode ilmu hukum yaitu memberikan penjelasan tentang bullying berdasarkan hukum yang berlaku dan berdasarkan fakta yang terjadi dalam lingkungan sehari-hari. Pelaksaanaan sosialisasi tentang bullying ini yaitu yang pertama memberikan materi dan contoh tentang bullying selanjutnya menjelaskan bagaimana dampak dan bahaya dari tindakan bullying dan terakhir menjelasakan bagaimana cara mencegah agar tidak terjadinya tindakan bullying. Penyuluhan atau sosialisasi tentang bullying ini didapatkan hasil yaitu anak-anak dan narapidana mendengarkan dengan jeli apa yang telah disampaikan mengenai bullying, yang telah dilaksanakan dalam kurun waktu 3 hari, sebagian dari anak-anak dan narapidana memahami semua materi yang sudah disampaikan. Dalam lingkungan sekolah anak-anak akan dibantu oleh guru-guru untuk mencegah tindakan bullying yaitu akan menerapkan peraturan yang tegas jika ada pelaku yang melakukan tindakan bullying di lingkungan sekolah. Dalam Lembaga Pemasyarakatan Kelas IIB Arga Makmur juga akan dilaksanakan peraturan atau hukum bagi narapidana yang melakukan tindakan bullying tersebut. Terakhir anak-anak dan narapidana diajarkan tentang cara bagaimana harus melawan tindakan bullying tersebut.

Kata Kunci : Sosialisasi, Dampak dan Bahaya, Bullying
Studi Pembuatan Kompos Organik Di SMP Negeri 02 Seberang Musi
Authors: Mahali Jalaluddin , Destriani  , Irwandi  
Published: May 2023

Banyaknya sampah terutama sampah dedaunan yang terdapat dilingkungan sekolah dapat menjadi masalah yang nyata bagi masyarakat di lingkungan sekolah tersebut. Penanganan yang tepat diperlukan dalam pengelolaan sampah tersebut agar dapat mengurangi dampak yang ditimbulkan. Salah satu alternatif yang digunakan dalam mengatasi permasalahan sampah yaitu pembuatan kompos. Kegiatan yang dilakukan oleh para siswa dan siswi di SMP Negeri 02 seberang Musi ini bertujuan untuk menghasilkan suatu produk dari sampah dedaunan yang terdapat dilingkungan sekolah yaitu produk kompos. Proses pembuatan diawali dengan pengarahan kepada para siswa tentang bagaimana cara pembuatan kompos tersebut. Berdasarkan kegiatan yang telah dilakukan, terciptalah suatu produk yaitu kompos yang dapat digunakan dalam beberapa hal tertentu seperti dapat membuat tanah menjadi lebih subur, sebagai pengganti pupuk kimia serta sebagai edukasi bagi para peserta didik tentang cara pembuatan pupuk kompos.
Kata kunci : Kompos Organik; Dedaunan; Edukasi