bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taguchi grey relational analysis for parametric optimization of incremental forming process of bimetallic Steel-CP Titanium composite sheet
Authors: arfa henia , HASSINE HICHEM 
Published: January 2023

Abstract
Single point incremental forming (SPIF) remains a new technique of sheet metal forming process in which can produce various shapes from different sheet alloys in small series. However, when the SPIF parameters are not sufficiently chosen, some forms of incremental sheet forming part quality can be inacceptable. This work aims to optimize geometry properties and forming forces of Steel/CP-Ti bimetal sheet formed by SPIF. Three levels of step size, the specimen thickness and the wall angle have been considered as the input process parameters. The influential process parameters on the thinning rate, forming forces and the equivalent plastic deformation have been recognized using of statistical tool. In this idea, a new current method, Taguchi grey relational analysis has been used to numerical simulations results in order to optimize incremental forming process parameters. The Taguchi-based Grey optimization of the single point incremental forming process is given for the determination of approving a synthesis of optimal process parameters such as the wall angle, the initial thickness, and the step size tool. Moreover, the individual effect factor on the considered output (Thinning Rate, Fz and PPEQ) was resolute with Analysis of variance (ANOVA). The response table and the grey relational grade for each level of the process parameters has been established.
Relationship between borderline personality traits, emotion regulation, and non-suicidal self-injury in depressed adolescents: a cross-sectional study
Authors: Chen Yang , Fu Wenxian , Ji Sifan , Zhang Wei , Sun Lingmin , Yang Tingting , He Kongliang , Zhou Yongjie 
Published: January 2023

Abstract

Objective: Non-suicidal self-injury (NSSI) is common among adolescents and has been linked to mental disorders and suicide in addition to physical injuries. According to the empirical avoidance model, adolescents with NSSI have stronger emotional experience and poorer emotional regulation than those without NSSI, which are core features of borderline personality disorder (BPD). The relationship between borderline personality features, emotion regulation, and NSSI in the population is unclear. This study aims to explore these associations and provide theoretical basis for the treatment of NSSI in the future.
Methods: Depressed adolescents (n = 1192) were evaluated using Chinese versions of the Function Assessment of Self-mutilation Scale, Emotional Regulation Questionnaire for Children and Adolescents, and Borderline Personality Features Scale for Children.
Results: The majority of depressed adolescents (71.3%, 850/1192) had demonstrated NSSI in the past year, with cutting or scratching the most common form (57.4%). Pearson correlation analysis with NSSI as a fixed factor (NSSI=1, no NSSI=2) revealed a negative correlation between NSSI and borderline personality characteristics (r = -0.314, P < 0.01) but a positive correlation between NSSI and emotion regulation capacity (r = 0.159, P < 0.01). This results are statistically significant. Emotion regulation played a mediating role between borderline personality traits and NSSI in adolescents with depression (effect value = 0.151).
Conclusion: Borderline personality features and emotional regulation ability were significantly correlated with non-suicidal NSSI in depressed adolescents. Borderline personality symptoms not only directly influence NSSI risk in adolescents with depression, but also indirectly influence NSSI risk through emotional regulation.
GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis
Authors: Lee Ji-Yun , Kim Joo-Won , Min Dong Wha , Kim Dasom , Kim Joohee , Kim Min Jung , Lim Hyangsoon 
Published: January 2023

Abstract
Ferroptosis is a type of programmed cell death, that can be induced by inhibiting antioxidant enzymes glutathione peroxidase 4 (GPX4) or cystine/glutamate transporter (system Xc−), increased intracellular concentrations of iron, and lipid peroxidation. Recently, it has been suggested that ferroptosis can be an effective way to induce cell death in various cancers, although the specific relevance and mechanism of ferroptosis have not been fully elucidated. In this study, the anticancer effects of ferroptosis inducers, erastin, and RSL3 on non-small cell lung cancer (NSCLC) cells were investigated. RSL3-induced cell death much more effectively in NSCLC cells than erastin with very limited cytotoxicity in BEAS-2B, normal bronchial epithelial cell. The sensitivity of NSCLC cells to RSL3-induced cell death was different among NSCLC cells, which was dependent on GPX4 expression levels, and rescued by ferrostatin-1, a ferroptosis inhibitor, but not by Z-VAD-FMK, chloroquine, bafilomycin A1, and necrostatain-1. RSL3 induced ferroptosis by increased lipid peroxidation, intracellular LIP concentration, and ROS, and inhibition of GSH to GSSH conversion through the inhibition of GPX4, and induction of Nrf2/HO1. Furthermore, RSL3 induced autophagosome, but disrupted formation of autolysosome from autophagosome. Knockdown of GPX4 had a similar effect on ferroptosis phenotypes to that of RSL3. Zebrafish xenograft model in vivo confirmed in vitro result of RSL3. Taken together, this study provides evidence that RSL3-induced ferroptosis depends on the regulation of GPX4- Nrf2/HO1 in NSCLC cells. This process may aid in predicting the ferroptosis response in NSCLC as well as drug resistant cancer cells.
Impact of statin treatment on cardiovascular risk in patients with type 1 diabetes: a population-based cohort study
Authors: Yoo Joonsang , Jeon Jimin , Baek Minyoul , Song Sun Ok , Kim Jinkwon 
Published: January 2023

Abstract
Background
Cardiovascular disease (CVD) is a major complication in type 1 diabetes mellitus (T1D) patients. Previous studies have suggested that statins may be helpful for prevention of CVD in T1D, but there are limited data on the role of statins in T1D. We investigated the relationship between statin treatment and cardiovascular risk in T1D patients using a population-based cohort.
Methods
We conducted a retrospective cohort study using the Korean nationwide health insurance database from January 2007 to December 2017. This study included 11,009 T1D patients aged ≥ 20 years without a prior history of CVD. The primary outcome was a composite development of stroke or myocardial infarction. Statin use during follow-up was treated as a time-varying variable. We performed a multivariable time-dependent Cox regression analysis adjusting for sex, age, type of insurance, hypertension, renal disease, and use of antiplatelets.
Results
During the 9.9 ± 3.7 years of follow-up, 931 T1D patients (7.1%) suffered primary outcome. Statin treatment was associated with a reduced risk of the primary outcome (adjusted hazard ratio, 0.75; 95% confidence interval, 0.65–0.87). Statin use led to decreased risks of ischemic stroke and myocardial infarction, but was not related to hemorrhagic stroke. We also found that the risk of cardiovascular events decreased as the cumulative exposure duration of statins increased.
Conclusions
Statin use was associated with a lower risk of cardiovascular events in TD1 patients. Further prospective studies are needed to confirm the potential role of statins in prevention of CVD in patients with T1D.
Light exposure behaviors predict mood, memory and sleep quality
Authors: Siraji Mushfiqul Anwar , Kalavally Vineetha , Haque Shamsul 
Published: January 2023

Abstract

Ample research has shown that light influences our emotions, cognition, and sleep quality. However, little research has investigated if different light exposure-related behaviors, such as the use of electric light during daytime, and use of gadgets before sleeping, influence those variables. Three-hundred-and-one Malaysian adults (MeanAge±SD=28 ± 9) completed the Light Exposure Behavior Assessment (LEBA) tool that measured five light exposure behaviors. They also completed the Morningness-Eveningness Questionnaire, Positive and Negative Affect Schedule, Pittsburgh Sleep Quality Index, and single items assessing trouble in memory and concentration. A partial least square structural equation model, showing 61.36% predictive power, revealed that increased use of wearable blue filters indoors and outdoors decreased the morningness affect (Direct effect, DE=-0.16) and sleep quality (Total effect, TE = 0.11). Increased time spent outdoors predicted positive affect (DE = 0.32) and early chronotype (DE: RI = 0.14, PT = 0.15, RT = 0.15). Increased use of gadgets before sleep predicted late chronotype (DE: RT=-0.26; RI=-0.23; PT=-0.24; MA=-0.13), increased negative affect, reduced sleep quality (DE = 0.13), and increased trouble in memory and concentration (TE = 0.20 & 0.23, respectively). Increased use of electric light in the morning and daytime predicted a positive affect (DE = 0.16) and sleep quality (DE=-0.16). The results provide valuable insights into developing a healthy light diet to promote health and wellness.
NKD1 targeting PCM1 regulates the therapeutic sensitivity of HHT on colorectal cancer cells
Authors: Cao Jia , Ma Rong , Wang Jia , Shi Bin , Zhao Jufen , Tian Jinhai , Huang Qi , Yu Jingjing , Tao Xiang , Wang Libin 
Published: January 2023

Abstract
Colorectal cancer (CRC) is the most common primary malignant tumor with a significantly higher incidence in the worldwide. Homoharringtonine (HHT) often used to treatment of acute leukemia. Recent research revealed it could be used for solid cancer therapy. However, the regulatory target and mechanism of HHT in CRC progression remain elusive. This study proved that HHT suppressed cell proliferation and promoted cell cycle arrest and apoptosis. Transcriptome sequence indicated that NKD1 was the target of HHT in CRC. HHT could suppress NKD1 expression in a concentration and time dependent manner. NKD1 was overexpressed in CRC tissues and depletion of NKD1 enhanced the therapeutic effect of HHT on CRC in vitro and vivo. Furthermore, proteomic analysis revealed that PCM1 involved in the process of cell proliferation and cell cycle regulated by NKD1. NKD1 interacts with PCM1, and NKD1 promotes the ubiquitination degradation of PCM1. Moreover, overexpression of PCM1 can effectively reverse the promoting effect of NKD1 interference on cell cycle arrest and apoptosis. These results suggested that the NKD1/PCM1 axis participated in mediating the therapeutic sensitivity of HHT to CRC. Our findings provide evidence for clinical application of NKD1-targeted therapy in improving HHT sensitivity for CRC treatment.
An experimental dynamic NMR study of 2-(aryl)-4,5-diphenyl-1H-imidazoles in solution: the evaluation of NH behavior in terms of proton transfer and tautomerism and its application on detecting of special protons and carbons of trisubstituted imidazoles
Authors: Yaghmaeiyan Nahid , Mirzaei Mahdi , Bamoniri Adolhamid 
Published: January 2023

Abstract
The proof of the tautomerism phenomenon and the exchange of protons bounded to nitrogen and oxygen is possible by evaluating the rate of proton exchange and factors that effect on it. For 2-(aryl)-4,5-diphenyl-1H-imidazoles, scrutiny of proton transfers and tautomerism is possible by evaluation of their proton and carbon spectra. This paper reports results of the studies on 1H and 13C NMR spectra of 2-(aryl)-4,5-diphenyl-1H-imidazoles in solution. We have investigated the dynamic NMR of these compounds based on concentration and introduce a way instead of TOCSY technique for detecting the overlapped signals of protons and carbons of aryl substituent which located in position 2 of imidazole ring.
Hybrid Kyphoplasty with Short-Segment versus Intermediate- and Long-Segment Pedicle Fixation for the Management of Thoracolumbar Burst Fractures
Authors: Chou Kuan-Nien , Wang Peng-Wei , Chung Ming-Hsuan , Ju Da-Tong 
Published: January 2023

Abstract
Background
Surgical treatment is usually recommended for thoracolumbar burst fractures (TLBFs) to mitigate the spinal deformity and/or neurological deficits. This study aimed to compare the clinical and radiographic outcomes of hybrid short-segment (HSS, four screws) technique with the traditional intermediate-segment (IS, six screws) and long-segment (LS, eight screws) pedicle screw fixations for treating acute TLBFs.
Methods
The patients in this study had acute single-level TLBFs with neurological deficits between levels T11 and L2, treated surgically between July 2013 and December 2019. We compared the surgical complications, blood loss, and operative duration of patients treated with the three pedicle screw techniques. We also compared postoperative thoracolumbar kyphotic degeneration between groups using the data on Cobb angles between the superior endplate of the vertebra above and inferior endplate of the vertebra below the fractured vertebra on lateral radiographic images at three time points (preoperatively, postoperative day 1, and postoperative follow-up). Forty-three patients were included: 15 treated with HSS, 12 with IS, and 16 with LS pedicle screw fixations. The end of follow-up (mean, 11.2 months) was defined as the most recent postoperative radiographic image or implant complication occurrence.
Results
We found significantly lower blood loss and shorter surgical durations in the HSS group than in the IS and LS groups. The HSS group exhibited the lowest rate of implant complications (13.33%), with the highest rate in the IS group (58.33%). Implant complications, including pedicle screw and rod dislodgement as well as pedicle screw damage and loosening, occurred at a mean follow-up of 7.5 (range: 6–9) months in the HSS group, 9 (range: 5–23) months in the IS group, and 7 (range: 1–21) months in the LS group. HSS patients demonstrated the most effective immediate kyphosis correction postoperatively. However, one patient underwent reoperation due to symptomatic cement leakage.
Conclusions
In the surgical treatment of single-level TLBFs, the HSS technique required a shorter operative duration and led to lower complication rates and operative blood loss than IS and LS approaches. This technique facilitates immediate kyphosis correction and successful maintenance of the corrected alignment 1 year later.
From the simulation of forest plantation dynamics to the quantification of bark-stripping damage by ungulates
Authors: Ligot Gauthier , Gheysen Thibaut , Perin Jérôme , Candaele Romain , de Coligny François , Licoppe Alain , Lejeune Philippe 
Published: January 2023

Abstract
Large ungulate populations are known to cause economic damage to agriculture and forestry. Bark damage is particularly detrimental to the timber production of certain species, including Picea abies (L.) Karst (Norway spruce): after bark is wounded, rot often spreads in the trunk base, damaging the most valuable log section. Numerous studies have provided valuable information on various aspects of this process, for example identifying factors governing tree sensitivity to bark-stripping or estimating the rate of decay spread in the trunk. The financial consequences over a full timber production cycle have nevertheless remained poorly quantified and uncertain. Coupling a forest dynamics model (GYMNOS) with models of damage occurrence and decay spread, we simulated the effect of ranging levels of bark-stripping damage on financial losses. The simulations were repeated for sites of ranging fertility and with different protection measures (fences or individual protections). The net present values of these different simulations were estimated and compared to estimate the cost of the damage and the cost-effectiveness of the damage protections. Protecting plantations against bark-stripping damage with fences was found unlikely to be worthwhile. By contrast, individual protections placed on crop trees could be helpful, particularly in the most fertile stands. Loss of revenue depended greatly on the factors tested: we estimated that the average damage cost could be about 53 €/ha/year, reducing timber yield by 19% in the study area, in Southern Belgium.
Why didn’t the caribou (Rangifer tarandus groenlandicus) cross the road? The barrier effect of traffic on industrial winter roads
Authors: Smith Angus , Johnson Chris J. 
Published: January 2023

Abstract
Barren-ground caribou are in steep decline due to the combined effects of climate change, natural population fluctuations, and anthropogenic disturbance. For the Indigenous peoples that rely on caribou for subsistence and cultural continuity, this decline presents a grave threat to a way of life. Wildlife managers are concerned about the potential effects of winter roads on the use of space by caribou. Roads, especially those with high levels of traffic, act as barriers to movement by ungulates. In the central Northwest Territories, Canada, the Tibbitt to Contwoyto Winter Road services diamond mines located on the winter range of several populations of barren-ground caribou. Impeded movement could restrict the distribution or influence the habitats used by caribou during winter. We investigated the influence of traffic volume and other disturbance and environmental variables on the road-crossing decisions of caribou. We used logistic regression to contrast observed and available crossing events by caribou that were recorded using high-precision GPS collars during 2018–2020. Of 62 collared caribou that moved near the winter road, only 33 crossed the winter road, for a total of 100 crossing events. Caribou rarely crossed the road when any level of traffic was present; the level of traffic, not the road right-of-way, was the underlying explanatory factor for that behavioural decision. Our results suggest that mitigation and associated monitoring should focus on strategies that minimize traffic volume or provide breaks in traffic when caribou are adjacent to winter roads.
A trial deep learning-based model for four-class histologic classification of colonic tumor from narrow band imaging
Authors: Shimizu Takeshi , Sasaki Yoshihiro , Ito Kei , Matsuzaka Masashi , Sakuraba Hirotake , Fukuda Shinsaku 
Published: January 2023

Abstract

Narrow band imaging (NBI) has been extensively utilized as a diagnostic tool for colorectal neoplastic lesions. This study aimed to develop a trial deep learning (DL) based four-class classification model for low-grade dysplasia (LGD); high-grade dysplasia or mucosal carcinoma (HGD); superficially invasive submucosal carcinoma (SMs) and deeply invasive submucosal carcinomas (SMd) and evaluate its potential as a diagnostic tool. We collected a total of 1390 NBI images as the dataset, including 53 LGD, 120 HGD, 20 SMs and 17 SMd. A total of 59,8801 patches were trimmed from the lesion and background. A patch-based classification model was built by employing a residual convolutional neural network (CNN) and validated by three-fold cross-validation. The patch-based validation accuracy was 0.876, 0.957, 0.907 and 0.929 in LGD, HGD, SMs and SMd, respectively. The image-level classification algorithm was derived from the patch-based mapping across the entire image domain, attaining accuracies of 0.983, 0.990, 0.964, and 0.992 in LGD, HGD, SMs, and SMd, respectively. Our CNN-based model demonstrated high performance for categorizing the histological grade of dysplasia as well as the depth of invasion in routine colonoscopy, suggesting a potential diagnostic tool with minimal human inputs.
Groundwater Quality Assessment using SPSS based on multivariate statics and water quality index of Gaya, Bihar.
Authors: ALAM AFTAB , SINGH ANSHUMAN 
Published: January 2023

Abstract
Groundwater is a valuable resource for developmental activities, and its demand is growing as surface water becoming scarce. Groundwater demand is increasing, resulting in reduction in water level and deterioration in water quality. 156 groundwater samples were taken in the district of Gaya, Bihar, to check the safety of drinking water. The quality of the obtained sample was assessed using a variety of physicochemical characteristics. For evaluating water quality, statistical methods were used as they are effective and efficient. This study uses SPSS software to perform multivariate statistical analysis on the groundwater samples. The quality of groundwater was assessed using a water quality index (WQI). 17% of the sample were found to be of very poor quality and not consumable. The KMO's sample adequacy value of 0.703 and the significance level of Bartlett's test of sphericity (0.0001) were calculated indicating that PCA may be implemented appropriately on the data to extract relevant information. Using the PCA, the three components recovered explained 69.581 percent of the total variation. A multivariate statistical method called cluster analysis is also used to draw conclusions from complicated data. The major parameters affecting the water quality in the study region are TDS, Ca2+, Mg2+, HCO3-, Cl-, F-, and PO42-. These results may be used for water quality assessment leading to improved environmental management and planning, and in decision-making for water quality management.
Understanding the Pathways between Exposure to Heavy Metals and Oncogenesis from a Public Health Perspective, a Rapid Review of Literature.
Authors: Varela-Jaramillo Santiago ,   Alex Taub-Krivoy1, Suarez-Gómez Santiago A. , Serrano Eduardo , Villamil-Patiño Gabriela , Torres Juan F. , Palencia-Sánchez Francisco 
Published: January 2023

Abstract

Cancer is one of the leading causes of death worldwide with progressively increasing incidence related to multiple pathophysiological mechanisms. According to WHO, in 2020 around 18.1 million new cases were reported being breast cancer, the most common with 2.26 million cases followed by lung with 2.20 million and colorectum with 1.93 million. The relationship between cancer and exogenous metal exposure is not new, nevertheless, it was not until recent years that clear pathways were described. Although many metallic elements are required for different physiological and biochemical pathways, at elevated concentrations they have different reported pathological mechanisms. When ingested, heavy metals get oxidized with gastric acid, some become lipophilic, and others induce Reactive Oxygen Species and disrupt processes involving DNA replication, protein synthesis, and folding. The most common heavy metal groups reported include Cadmium (Cd), Lead (Pb), Nickel (Ni), Chromium (Cr), Mercury (Hg), Arsenic (As), and Zinc (Zn), among others. The main objective of this study is to review, the different mechanisms proposed for oncogenesis related to exposure to heavy metal carcinogenesis including, a broad approach to the epidemiology of cancer and its relationship with heavy metals and synthesizing the evidence related to the carcinogenesis of heavy metals and describe the pathophysiological pathway involved in oncogenesis.