bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined intravitreal dexamethasone and bevacizumab injection for the treatment of persistent diabetic macular edema (DexaBe study): a phase I clinical study
Authors: Veiga Reis Francyne , Dalgalarrondo Pedro , da Silva Tavares Neto José Edisio , Wendeborn Rodrigues Murilo , Scott Ingrid U. , Jorge Rodrigo 
Published: March 2023

Abstract
Purpose
The aim of this study is to investigate the safety of combined intravitreal injection of dexamethasone aqueous-solution (IVD) and bevacizumab (IVB) in patients with refractory diabetic macular edema (DME) and its effect on intraocular pressure (IOP), best-corrected visual acuity (BCVA) and central subfield thickness (CSFT).

Methods
This prospective study included 10 patients (10 eyes) with DME refractory to laser photocoagulation and/or anti-vascular endothelial growth factor (anti-VEGF) therapy. A complete ophthalmological examination was performed at baseline, during the first week of treatment, and monthly through week 24. Therapy consisted of monthly injections of combined IVD and IVB “pro re nata” (PRN) if CST > 300 µm. We investigated the impact of the injections on intraocular pressure (IOP), cataract development, Early Treatment Diabetic Retinopathy Study (ETDRS) best corrected visual acuity (BCVA), and central sub-foveal thickness (CSFT) measured by spectral-domain optical coherence tomography (OCT).

Results
Eight patients (80%) completed 24 weeks of follow-up. Compared to baseline, mean IOP increased significantly (p < 0.05) and anti-glaucomatous eye drops were necessary for 50% of the patients, CSFT was significantly reduced at all follow-up visits (p < 0.05), although mean BCVA showed no significant improvement. One patient developed dense cataract progression and another showed vitreoretinal traction at week 24. No inflammation or endophthalmitis was observed.

Conclusion
Treatment of DME refractory to laser and/or anti-VEGF therapy with combined PRN IV dexamethasone aqueous solution and bevacizumab was associated with adverse effects related to the use of corticosteroids. However, there was a significant improvement in CSFT meantime best-correct visual acuity remained stable or improved in 50% of patients.
Evaluation of HLA-B51 frequency and its relationship with clinical findings in patients with Behçet’s disease: 4-year analysis in a single center
Authors: Erdem Sultanoğlu Tuba , Eröz Recep , Ataoğlu Safinaz 
Published: March 2023

Abstract
Background
The clinical findings of Behçet’s disease (BD) differ according to the country and race investigated. The most important genetic factor known in the pathogenesis of BD is HLA-B51, and this positivity is high in countries on the “Silk Road” where BD is as frequent as it is in Turkey. Although the positivity of HLA B51 is proven to be high in Turkey, there are no studies in the area of the western Black sea demonstrating its relation to the demographic. We aimed to investigate the association of HLA-B51 positivity in Turkish patients diagnosed as having BD and the relationship between the demographic and clinical findings of the patients.

Results
In this descriptive, cross-sectional study, a convenience sample of adults with BD was obtained from an outpatient clinic of a university hospital in Turkey between January 2018 and January 2022. Patients were diagnosed as having BD according to the criteria of the International BD Study Group, and the patients’ sociodemographic and clinical characteristics were recorded retrospectively. Demographic data and the frequency of clinical findings were compared between patients who were HLA-B51-positive and HLA-B51-negative. Sixty patients (55.6%) were HLA-B51-positive. Oral ulceration, genital ulceration, thrombophlebitis, and family history of BD were found to be higher in patients who were HLA-B51-positive. Erythema nodosum, papulopustular eruption, pathergy positivity, arthritis, and ocular involvement were less frequent in patients with HLA-B51 positivity. However, there were no statistically significant differences according to the frequency of clinical findings between the HLA-B51-positive and HLA-B51-negative groups.

Conclusions
HLA B51 positivity is not diagnostic of BD; however, it may affect clinical phenotypes. Although oral and genital ulcerations, thrombophlebitis, and positive family history of BD were found to be common in patients with HLA-B51 positivity, this relationship could not reach statistical significance.
Dipolar particles trapped in a cylindrical pore
Authors: Mourad A. , Mohrbach H. , Messina R. 
Published: March 2023

Abstract
A salient effect of strong confinement, especially when quasi one-dimensional, is to drastically alter the phase behavior and concomitantly the physico-chemical properties of a substance encountered in the bulk. The ground state phase diagram of dipolar hard spheres of diameter d as a function of the pore opening

, with D being the cylinder diameter of the confining pore, is investigated theoretically. Whereas finding the densest configurations with hard spheres would be a purely geometrical problem, the situation becomes much more intricate with long-ranged anisotropic interactions. As a major finding, long pores prohibit chain undulation (helicity) and wall-contact–free (floating) linear chain bundles emerge. These results shed light on recent experimental observations with magnetic colloids in microtubes. Applications in other fields are discussed as well.
Birth process of electron-positron pairs inside supercritical fields
Authors: Gong C. , Su Q. , Grobe R. 
Published: March 2023

Abstract
We propose a computational quantum field theoretical approach to obtain a microscopic insight into the creation process of electrons and positrons as well as their subsequent motion inside a supercritical external field with space-time resolution. A machine-learning–based method permits us to address fundamental questions such as where inside the interaction region the particles are being created and what their initial velocity distribution is. It suggests that the particles' most likely birth positions change in time during the dynamics. At early times the particles' birth density is roughly proportional to the square of the force field, but in the long-time and steady state production regime their possible birth locations narrow down significantly. Counterintuitively, this leads for longer times to the occurrence of “birth-free” zones within the field, where particles are no longer created even though the electric field is maximal there. The genetic-programming–based symbolic regression algorithms first learn multiple sequences of partially dressed positronic spatial probability densities as training data and then exploit their features as a function of the dressing strength in order to predict the particles' true distribution in space and momentum.
Preoperative Partial Breast Irradiation in Patients with Low-Risk Breast Cancer: A Systematic Review of Literature
Authors: Civil Yasmin A. , Jonker Lysanne W. , Groot Koerkamp Maartje P. M. , Duvivier Katya M. , de Vries Ralph , Oei Arlene L. , Slotman Berend J. , van der Velde Susanne , van den Bongard H. J. G. Desirée 
Published: March 2023

Abstract
Background
Preoperative instead of standard postoperative partial breast irradiation (PBI) after breast-conserving surgery (BCS) has the advantage of reducing the irradiated breast volume, toxicity, and number of radiotherapy sessions and can allow tumor downstaging. In this review, we assessed tumor response and clinical outcomes after preoperative PBI.

Patients and Methods
We conducted a systematic review of studies on preoperative PBI in patients with low-risk breast cancer using the databases Ovid Medline, Embase.com, Web of Science (Core Collection), and Scopus (PROSPERO registration CRD42022301435). References of eligible manuscripts were checked for other relevant manuscripts. The primary outcome measure was pathologic complete response (pCR).

Results
A total of eight prospective and one retrospective cohort study were identified (n = 359). In up to 42% of the patients, pCR was obtained and this increased after a longer interval between radiotherapy and BCS (0.5–8 months). After a maximum median follow-up of 5.0 years, three studies on external beam radiotherapy reported low local recurrence rates (0–3%) and overall survival of 97–100%. Acute toxicity consisted mainly of grade 1 skin toxicity (0–34%) and seroma (0–31%). Late toxicity was predominantly fibrosis grade 1 (46–100%) and grade 2 (10–11%). Cosmetic outcome was good to excellent in 78–100% of the patients.

Conclusions
Preoperative PBI showed a higher pCR rate after a longer interval between radiotherapy and BCS. Mild late toxicity and good oncological and cosmetic outcomes were reported. In the ongoing ABLATIVE-2 trial, BCS is performed at a longer interval of 12 months after preoperative PBI aiming to achieve a higher pCR rate.
The number of neutral mutants in an expanding Luria-Delbrück population is approximately Fréchet
Authors: Frank Steven A. 
Published: March 2023

Background: A growing population of cells accumulates mutations. A single mutation early in the growth process carries forward to all descendant cells, causing the final population to have a lot of mutant cells. When the first mutation happens later in growth, the final population typically has fewer mutants. The number of mutant cells in the final population follows the Luria-Delbrück distribution. The mathematical form of the distribution is known only from its probability generating function. For larger populations of cells, one typically uses computer simulations to estimate the distribution. Methods: This article searches for a simple approximation of the Luria-Delbrück distribution, with an explicit mathematical form that can be used easily in calculations. Results: The Fréchet distribution provides a good approximation for the Luria-Delbrück distribution for neutral mutations, which do not cause a growth rate change relative to the original cells. Conclusions: The Fréchet distribution apparently provides a good match through its description of extreme value problems for multiplicative processes such as exponential growth.
The disconnect between researcher ambitions and reality in achieving impact in the Earth & Environmental Sciences – author survey
Authors: Kelly Andrew , Gardner Victoria , Gilbert Anna 
Published: March 2023

Background: There is an increasing desire for research to provide solutions to the grand challenges facing our global society, such as those expressed in the UN SDGs (“real-world impact”). Herein, we undertook an author survey to understand how this desire influenced the choice of research topic, choice of journal, and preferred type of impact. Methods: We conducted a survey of authors who had published in >100 of our Earth & Environmental Science journals. The survey was sent to just under 60,000 authors and we received 2,695 responses (4% response rate). Results: Respondents indicated that the majority of their research (74%) is currently concerned with addressing urgent global needs, whilst 90% of respondents indicated that their work either currently contributed to meeting real-world problems or that it would be a priority for them in the future; however, the impetus for this research focus seems to be altruistic researcher desire, rather than incentives or support from publishers, funders, or their institutions. Indeed, when contextualised within existing reward and incentive structures, respondents indicated that citations or downloads were more important to them than contributing to tackling real-world problems. Conclusions: At present, it seems that the laudable and necessary ambition of researchers in the Earth & Environmental Sciences to contribute to the tackling of real-world problems, such as those included in the UN SDGs, is seemingly being lost amidst the realities of being a researcher, owing to the prioritisation of other forms of impact, such as citations and downloads.
Medical student flourishing before and during the COVID-19 pandemic at one U.S. institution
Authors: Kelly-Hedrick Margot , Iuliano Kayla , Tackett Sean , Chisolm Margaret S. 
Published: March 2023

Introduction: Medical education research often focuses on measuring negative mental states like burnout, rather than focusing on positive states like well-being. Flourishing – a state that includes domains of happiness and mental health - is a way of thinking about well-being that may be relevant to education and research. The purpose of this prospective, observational study was to compare the relationship among flourishing, other well-being measures, and burnout in medical students via a survey administered at two time points. Methods: We surveyed medical students at one U.S. institution about their flourishing, satisfaction with work-life balance, quality of life, empathic concern, and burnout (emotional exhaustion and depersonalization) before and after the onset of the COVID-19 pandemic. Flourishing was measured using two scores, the Flourish Index (FI) and Secure Flourish Index (SFI), with higher scores indicating greater flourishing. Pre- and post-scores for both measures were compared. Results: 107/585 (18%) medical students responded to the survey and 78/107 (73%) participated in the post survey. At the first time point, respondents reported both a mean FI and SFI 6.7 (SD=1.3); higher levels of flourishing correlated with higher satisfaction with work-life balance (p<.001), higher quality of life (p<.001), and lower levels of burnout (emotional exhaustion p<.001; depersonalization p=.021). SFI scores were higher at the second time point (M=7.1, SD=1.2) than the first (M=6.7, SD=1.3, p=.026). FI, satisfaction with work-life balance, quality of life, empathic concern, and burnout were unchanged at the second time point. Discussion: Like past findings in medical residents, we found medical students’ flourishing—as measured by FI and SFI scores—correlated with greater satisfaction with work-life balance, higher quality of life, and lower burnout. In this limited sample, we found flourishing remained largely unchanged after the COVID-19 pandemic onset.
Graduate health professions education programs as they choose to represent themselves: A website review
Authors: Schermerhorn Janse , Wilcox Shelby , Durning Steven , Costello Joseph , Norton Candace , Meyer Holly 
Published: March 2023

Introduction: In an age of increasingly face-to-face, blended, and online Health Professions Education, students have more choices of institutions at which to study their degree. For an applicant, oftentimes, the first step is to learn more about a program through its website. Websites allow programs to convey their unique voice and to share their mission and values with others such as applicants, researchers, and academics. Additionally, as the number of health professions education (HPE) programs rapidly grows, websites can share the priorities of these programs. Methods: In this study, we conducted a website review of 158 HPE websites to explore their geographical distributions, missions, educational concentrations, and various programmatic components. Results: We compiled this information and synthesized pertinent aspects, such as program similarities and differences, or highlighted the omission of critical data. Conclusions: Given that websites are often the first point of contact for prospective applicants, curious collaborators, and potential faculty, the digital image of HPE programs matters. We believe our findings demonstrate opportunities for growth within institutions and assist the field in identifying the priorities of HPE programs. As programs begin to shape their websites with more intentionality, they can reflect their relative divergence/convergence compared to other programs as they see fit and, therefore, attract individuals to best match this identity. Periodic reviews of the breadth of programs, such as those undergone here, are necessary to capture diversifying goals, and serves to help advance the field of HPE as a whole.
Can Global Sourcing Strategy Predict Stock Returns?
Authors: Jain Nitish , Wu Di (Andrew) 
Published: March 2023

Problem definition: Whereas firms are increasingly relying on sourcing globally as a key constituent of their supply chain strategy, there is no empirical evidence on whether investors of these firms adequately reflect firms’ global sourcing strategy (GSS) in their stock-valuation process. In this paper, we empirically test whether stock market participants are efficient in doing so. Methodology/results: Using the empirical asset-pricing framework, we find that information concerning firms’ GSS strongly predicts their future stock returns. We compile a transaction-level imports database for U.S.-listed firms and construct measures for five widely studied GSS aspects in the operations management literature: the extent of global sourcing, supplier relationship strength, supplier concentration, sourcing lead time, and sourcing countries’ logistical efficiency. For each measure, we examine returns of a zero-cost investment strategy of buying from the highest and selling from the lowest quintile of that measure. Collectively, these investment strategies yield an average annual four-factor alpha of 6%–9.6% (6%–13.9%) with value (equal)-weighted portfolios. Their return predictability is incremental over other operations- and cost arbitrage–motivated predictors, such as inventory turnover, cash conversion cycle, and gross profitability; is persistent across different supply chain positions; and is robust to alternate risk models, subsamples, and empirical specifications. Together, our results indicate that the GSS measures embody independent information about firms’ future profitability, and this information is mispriced by market participants, leading to predictable returns. In accordance with this mechanism, we find that the GSS measures strongly predict both firms’ future earnings and the surprise in market reactions around the earnings announcement days. Managerial implications: The robust return predictability of our GSS measures suggests that investors are not fully incorporating GSS-related information in their stock valuation frameworks. Therefore, our results call for greater investor education on global sourcing and better dissemination of global-sourcing information so as to mitigate valuation inefficiency. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.1189 .
Periodontal disease in chronic kidney disease patients: salivomics by Fourier-transform infrared spectroscopy
Authors: Teodoro Nepomuceno Gabrielle , Silva Neres dos Santos Raquel , Avance Pavese Larissa , Parize Graziele , Pallos Debora , Sorelli Carneiro-Ramos Marcela , da Silva Martinho Herculano 
Published: March 2023

It has been reported that 58% of individuals with chronic kidney disease (CKD) have moderate to advanced periodontitis due to alterations of pH and biochemical composition in the saliva. In fact, the composition of this important biofluid may be modulated by systemic disorders. Here we investigate the micro-reflectance Fourier-transform infrared spectroscopy (FTIR) spectra of saliva that CKD patients submitted to periodontal treatment, aiming to identify spectral biomarkers of kidney disease evolution and the effectiveness of periodontal treatment, proposing possible biomarkers of disease evolution. Saliva from 24 CKD patients—stage-5 men, 29 to 64 years old—was evaluated in (i) patients starting periodontal treatment; (ii) patients 30 days after periodontal treatment; and (iii) patients 90 days after periodontal treatment. Our findings indicated that there are statistically relevant changes among the groups after 30 and 90 days of periodontal treatment, when considering the overall spectra in the fingerprint region (800−1800cm−1). The key bands presenting good prediction power (area under the receiver operating characteristic curve >0.70) were related to poly (ADP-ribose) polymerase (PARP) conjugated to DNA at 883, 1031, and 1060cm−1 (carbohydrates at 1043 and 1049cm−1) and triglycerides (1461cm−1). Interestingly when analyzing the derivative spectra in the secondary structure region (1590−1700cm−1), we detected over-expression of the β-sheet class of secondary structures in 90 days of periodontal treatment, possibly related to over-expression of human B-defensins. Conformational changes in ribose sugar in this region corroborate the interpretation concerning PARP detection. To our knowledge, PARP was detected for the first time in saliva samples of stage-5 CKD patients by FTIR. All observed changes were correctly interpreted in terms of intensive apoptosis and dyslipidemia due to kidney disease progression. Biomarkers due to CKD predominate in saliva, and the relative improvement in the periodontal state did not cause remarkable changes in the spectra of saliva.
A systematic review of published literature on mosquito control action thresholds across the world
Authors: Aryaprema Vindhya S. , Steck Madeline R. , Peper Steven T. , Xue Rui-de , Qualls Whitney A. 
Published: March 2023

Background
Despite the use of numerous methods of control measures, mosquito populations and mosquito-borne diseases are still increasing globally. Evidence-based action thresholds to initiate or intensify control activities have been identified as essential in reducing mosquito populations to required levels at the correct/optimal time. This systematic review was conducted to identify different mosquito control action thresholds existing across the world and associated surveillance and implementation characteristics.

Methodology/Principal findings
Searches for literature published from 2010 up to 2021 were performed using two search engines, Google Scholar and PubMed Central, according to PRISMA guidelines. A set of inclusion/exclusion criteria were identified and of the 1,485 initial selections, only 87 were included in the final review. Thirty inclusions reported originally generated thresholds. Thirteen inclusions were with statistical models that seemed intended to be continuously utilized to test the exceedance of thresholds in a specific region. There was another set of 44 inclusions that solely mentioned previously generated thresholds. The inclusions with “epidemiological thresholds” outnumbered those with “entomological thresholds”. Most of the inclusions came from Asia and those thresholds were targeted toward Aedes and dengue control. Overall, mosquito counts (adult and larval) and climatic variables (temperature and rainfall) were the most used parameters in thresholds. The associated surveillance and implementation characteristics of the identified thresholds are discussed here.

Conclusions/Significance
The review identified 87 publications with different mosquito control thresholds developed across the world and published during the last decade. Associated surveillance and implementation characteristics will help organize surveillance systems targeting the development and implementation of action thresholds, as well as direct awareness towards already existing thresholds for those with programs lacking available resources for comprehensive surveillance systems. The findings of the review highlight data gaps and areas of focus to fill in the action threshold compartment of the IVM toolbox.