bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between three-year mortality after transcatheter aortic valve implantation and paravalvular regurgitation graded by videodensitometry in comparison with visual grading
Authors: Elzomor Hesham , Neumann Timotheus J. , Boas Linus , Ruile Philipp , Abdelshafy Mahmoud , Elkoumy Ahmed , Revaiah Pruthvi C. , Tsai Tsung-Ying , Kaier Klaus , Soliman Osama , Ferenc Miroslaw , Westermann Dirk , Neumann Franz-Josef , Serruys Patrick , Schoechlin Simon 
Published: August 2023

Abstract
Background
Estimation of regurgitant fraction by videodensitometry (VD-AR) of aortic root angiograms is a new tool for objective grading of paravalvular regurgitation (PVR) after transcatheter aortic valve implantation (TAVI). Stratification with boundaries at 6% and 17% has been proposed to reflect “none/trace”, “mild” and “moderate or higher” PVR.

Objective
We sought to investigate the association of strata of VD-AR with 3-year mortality and to compare VD-AR with visual grading of angiograms.

Methods
We interrogated our database for patients undergoing transfemoral TAVI from 2008 to 2018. Vital status of the patients was obtained from population registers. To test differences in survival and estimate adjusted hazard ratios (HRs) we fitted Cox models.

Results
Our retrospective study included 699 patients with evaluable angiograms at completion of the TAVI procedure. Cumulative 3-year mortality was 35.0% in 261 (37.3%) patients with VD-AR < 6%, 33.9% in 325 (46.5%) patients with VD-AR between 6 and 17% (HR [95% confidence interval] 1.06 [0.80–1.42]; P = 0.684) and 47.2% in 113 (16.2%) patients with VD-AR > 17% (HR 1.57 [1.11–2.22]; P = 0.011). Visually, PVR was graded as “none/trace” in 470 (67.2%) patients, as “mild” in 219 (31.3%) and as “moderate” in 10 (1.4%). Both mild PVR and moderate PVR on visual grading were significantly associated with mortality (HRs 1.31 [1.12–1.54]; P = 0.001 and 1.92 [1.13–3.24]; P = 0.015; respectively).

Conclusions
VD-AR > 17%, but not VD-AR 6–17%, was independently associated with mortality. Compared with subjective visual evaluation, VD-AR resulted in a smaller proportion of patients with PVR classified as prognostically relevant.

Graphical Abstract
Pain-related evoked potentials with concentric surface electrodes in patients and healthy subjects: a systematic review
Authors: Bubenzer Laura Josephine , Konsolke Lena , Enax-Krumova Elena , Eberhardt Frederic , Tegenthoff Martin , Höffken Oliver , Özgül Özüm Simal 
Published: August 2023

AbstractPain-related evoked potentials with concentric surface electrodes (PREP with CE) have been increasingly used in the diagnostics of polyneuropathies as well as in pain research. However, the study results are partly inconsistent regarding their utility to distinguish between normal and abnormal findings. The present systematic review aimed to summarise and compare study results, where PREP with CE were used in healthy subjects or patients and to identify possible influencing factors. We found 36 research articles, of which 21 investigated disorders in patients compared to healthy controls, while the other 15 focussed on basic research in healthy subjects. Patients with polyneuropathies showed the most consistent PREP results with similar prolonged latencies and reduced amplitude values. Findings in other patient groups or in healthy subjects were more heterogeneous. There was evidence for an influence by age and height as well as by central effects like emotions, which should be considered in further studies. Further systematic research analysing PREP results depending on individual and disease-specific factors is needed to develop optimal normative values.
Clinical characteristics and pathologic complete response (pCR) rate after neoadjuvant chemotherapy in postpartum women with breast cancer
Authors: Dou He , Jia Siyuan , Ba Yuling , Luo Danli , Yu Pingyang , Li Fucheng , Wang Youyu , Chen Xingyan , Xiao Min 
Published: August 2023

Abstract
Purpose
Breast cancer (BC) is currently the leading cause of death in women worldwide. Studies have confirmed that pregnancy is an independent factor affecting the survival of BC patients. BC found during pregnancy, lactation, or shortly after delivery is what we used to think of as pregnancy-associated breast cancer (PABC). The current expert definition of this concept is not uniform; however, there is growing evidence that postpartum breast cancer (PPBC) differs from other types of BC in terms of both biological features and prognosis, with a slightly different focus on diagnosis and treatment. With the increase of female reproductive age population and changes in fertility policies in China, patients with PPBC are receiving increasing attention. Here, we systematically analyzed the clinicopathological characteristics and chemotherapeutic response of patients with PPBC. We retrospectively analyzed the clinicopathological data, molecular subtypes, chemotherapy regimens, and pathological complete remission (pCR) rates of 1343 patients with non-metastatic BC at Harbin Medical University Cancer Hospital from January 1, 2012 to May 31, 2023. The categorical data were compared by chi-square test and Fisher exact test using logistic regression model. Predictor variables with P < 0.05 in the univariate analysis were included in the multivariate regression analysis to investigate the relationship between different age groups and pCR.

Results
A total of 714 patients were eligible for analysis in this study, and 667 patients had a history of pregnancy, 40 (5.6%) of whom were PPBC patients. When diagnosed with BC, patients with PPBC were younger, more likely to undergo breast-conserving surgery (BCS), and more likely to achieve pCR (P < 0.05). In molecular typing, human epidermal growth factor receptor 2 (HER-2)-positive and triple-negative breast cancer (TNBC) were more frequent. In the entire cohort, HER-2 expression and delivery status were independent predictors of pCR rates in BC patients after neoadjuvant chemotherapy (NAC).

Conclusion
Our findings suggest that postpartum status is an independent predictor of pCR attainment in BC patients. PPBC is more sensitive to chemotherapy than other patients.We need to pay more attention to this group and achieve individualized treatment, which will help us treat BC better and provide new targets and blueprints for our clinical therapy.
Microbiota as the unifying factor behind the hallmarks of cancer
Authors: Benešová Iva , Křížová Ľudmila , Kverka Miloslav 
Published: August 2023

AbstractThe human microbiota is a complex ecosystem that colonizes body surfaces and interacts with host organ systems, especially the immune system. Since the composition of this ecosystem depends on a variety of internal and external factors, each individual harbors a unique set of microbes. These differences in microbiota composition make individuals either more or less susceptible to various diseases, including cancer. Specific microbes are associated with cancer etiology and pathogenesis and several mechanisms of how they drive the typical hallmarks of cancer were recently identified. Although most microbes reside in the distal gut, they can influence cancer initiation and progression in distant tissues, as well as modulate the outcomes of established cancer therapies. Here, we describe the mechanisms by which microbes influence carcinogenesis and discuss their current and potential future applications in cancer diagnostics and management.
Stationary and non-stationary temperature-duration-frequency curves for Australia
Authors: Laz Orpita U. , Rahman Ataur , Ouarda Taha B. M. J. , Jahan Nasreen 
Published: August 2023

AbstractAustralian summer heat events have become more frequent and severe in recent times. Temperature-duration-frequency (TDF) curves connect the severity of heat episodes of various durations to their frequencies and thus can be an effective tool for analysing the heat extremes. This study examines Australian heat events using data from 82 meteorological stations. TDF curves have been developed under stationary and non-stationary conditions. Generalised Extreme Value (GEV) distribution is considered to estimate extreme temperatures for return periods of 2, 5, 10, 25, 50 and 100 years. Three major climate drivers for Australia have been considered as potential covariates along with Time to develop the non-stationary TDF curves. According to the Akaike information criterion, the non-stationary framework for TDF modelling provides a better fit to the data than its stationary equivalent. The findings can be beneficial in offering new information to aid climate adaptation and mitigation at the regional level in Australia.
Modic change is associated with increased BMI but not autoimmune diseases in TwinsUK
Authors: Gualdi Francesco , Smith Isabelle Granville , Boixader Roger Compte , Williams Frances M. K. 
Published: August 2023

Abstract
Purpose
Low back pain (LBP) is one of the largest causes of morbidity worldwide. The aetiology of LBP is complex, and many factors contribute to the onset. Bone marrow lesions within the vertebra adjacent to an intervertebral degenerate disc named Modic change (MC) have been suggested as a diagnostic subgroup of LBP. Autoimmune response has been proposed to be one of the causes that promote the development of MC. The aim of the current investigation is to assess prevalence and severity of MC and LBP in participants with an autoimmune disease diagnosis in a well-documented cohort of adult twin volunteers.

Methods
Multivariate generalized mixed linear models (GLMM) were implemented in order to calculate the association between having an autoimmune disorder and MC prevalence, width and severe and disabling LBP. The model was corrected for family structure as well as for covariates such as age, BMI and smoking.

Results
No association was found between diagnosis of autoimmune disorder and MC. Interestingly, BMI was independently associated with MC width but not to MC prevalence. These results help to shed light on the relationship between MC and autoimmunity as well as the role of BMI in the development of the lesions.

Conclusion
This study is the first to examine autoimmune disorders and MC prevalence in a large, population-based female cohort. The study was well powered to detect a small effect. No association was found between having a diagnosis of one or more autoimmune conditions and MC prevalence, width or LBP.
Assessing the Fracturing Process of Rocks Based on Burst–Brittleness Ratio (BBR) Governed by Point Load Testing
Authors: Khadivi Babak , Masoumi Hossein , Heidarpour Amin , Zhang Qianbing , Zhao Jian 
Published: August 2023

AbstractBrittleness is an intrinsic mechanical property of rock materials that has attracted significant attention to be properly quantified as it plays an important role in characterization of brittle fracturing. Endeavors have led to the establishment of many Brittleness Indices (BIs) for various rock types and widespread engineering applications. Among them, assessing burst proneness as a serious challenge in underground mining has received considerable attention. Parallel to BIs' development, various Bursting Liability Indices (BLIs) have been proposed to specifically assess coal bursting phenomenon. Despite having different names, both BI and BLI in principle have aimed at evaluating the burst–brittleness level of different rocks for different applications. In this study, the principles of burst and brittleness were discussed followed by the development of a novel so-called burst–brittleness ratio (BBR) to assess the relative burst–brittleness of rock types irrespective of their applications. To do so, the proposed BBR was governed by point load testing (PLT) which has significant advantages over the other rock testing methods used in BI estimation such as direct or indirect tensile testing. To examine the suitability of the proposed ratio, three different rock types from various geological origins including coal, granite and sandstone were selected and tested under uniaxial compressive, indirect tensile Brazilian and point loadings. The high-speed imaging technique and Acoustic Emission (AE) were utilized to characterize the cracking process (e.g., failure under shear or tension) and to monitor the real-time failure behavior of samples under different loading conditions. The resulting data revealed that the severity of strength loss in coal samples was significantly higher than that observed in other rock types particularly under uniaxial compression endorsing the validity of the proposed BBR.
Long-term follow-up and comparison of programmable and non-programmable ventricular cerebrospinal fluid shunts among adult patients with different hydrocephalus etiologies: a retrospective cohort study
Authors: Chen Kuan-Hung , Hsu Peng-Wei , Wu Bo-Chang , Tu Po-Hsun , Wang Yu-Chi , Lee Cheng-Chi , Huang Yin-Cheng , Chen Ching-Chang , Chuang Chi-Cheng , Liu Zhuo-Hao 
Published: August 2023

Abstract
Background
Programmable valve (PV) has been shown as a solution to the high revision rate in pediatric hydrocephalus patients, but it remains controversial among adults. This study is to compare the overall revision rate, revision cause, and revision-free survival between PV and non-programmable valve (NPV) in adult patients with different hydrocephalus etiologies.

Method
We reviewed the chart of all patients with hydrocephalus receiving index ventricular cerebrospinal fluid (CSF) shunt operations conducted at a single institution from January 2017 to December 2017. Patients included in the study were followed up for at least 5 years. Statistical tests including independent t-test, chi-square test, and Fisher’s exact test were used for comparative analysis, and Kaplan-Meier curve using log-rank test was performed to compare the revision-free survival between the PV and NPV groups.

Results
A total of 325 patients were included in the study, of which 181 patients were receiving PVs and 144 patients receiving NPV. There were 23 patients (12.8%) with PV and 22 patients (15.3%) with NPV receiving initial revision. No significant statistical difference in the initial revision rate was observed between the two groups (p = 0.52). No survival difference was found between the PV and NPV groups. However, better revision-free survival was noted in the PV group among idiopathic normal pressure hydrocephalus (iNPH) (p = 0.0274) and post-traumatic hydrocephalus (p = 0.017).

Conclusions
The combination of the different etiologies of hydrocephalus and the features of PV and NPV results in different outcomes—revision rate and revision-free survival. PV use might be superior to NPV in iNPH and post-traumatic hydrocephalus patients. Further studies are needed to clarify the indications of PV use in adult hydrocephalus patients.
Adverse events in spine surgery: a prospective analysis at a large tertiary center in Germany
Authors: Lenga Pavlina , Trong Philip Dao , Papakonstantinou Vassilios , Kiening Karl , Unterberg Andreas W. , Ishak Basem 
Published: August 2023

Abstract
Study design
Prospective study

Objectives
The occurrence of adverse events (AEs) during surgery is a major cause of increased economic costs, disability, or even death. This study aimed to prospectively identify and quantify AEs in patients undergoing spinal surgery at a neurosurgical tertiary care hospital.

Methods
Patients who underwent spinal surgery and were discharged between January 2019 and December 2022 were enrolled prospectively. Each patient underwent a peer-reviewed AE evaluation at discharge. An AE was defined as any event that occurred up to 30 days postoperatively and resulted in an undesirable outcome. Patients were allocated to four groups according to spinal pathology (degenerative, oncologic, traumatic, and infectious).

Results
During the study period, 1778 patients with a mean age of 55.4 ± 10.5 years underwent surgery. Elective surgery was performed in 90.8% (1615/1778) of patients, while emergency surgery was performed in 9.2% (163/1778). The overall rate of surgery-related AEs was relatively low (8.7%). Degenerative pathologies were the most frequent reasons for surgery (78.5%, 1396/1778). Wound infection was the most prevalent AE in patients with degenerative diseases (1.4%), of which 1.1% required revision surgery. Wound infection, dural leakage, and new neurological deficits had the same prevalence (2.1%) in patients with spinal tumors. Among patients with spinal trauma, two presented with postoperative epidural bleeding and underwent emergency surgery. Postoperative wound infection was the most prevalent AE in this group (9.5%), with 7.0% of affected patients requiring revision surgery. The overall rate of non-surgery-related AEs was 4.3%, and the overall mortality rate was low (0.4%).

Conclusion
AEs in spinal surgery remained low, with a prevalence of 8.7%. Documentation of AEs as part of clinical routine may be a key tool for identifying the occurrence of surgery-related and non-surgery-related AEs.
Dimensionality selection for hyperbolic embeddings using decomposed normalized maximum likelihood code-length
Authors: Yuki Ryo , Ike Yuichi , Yamanishi Kenji 
Published: August 2023

AbstractGraph embedding methods are effective techniques for representing nodes and their relations in a continuous space. Specifically, the hyperbolic space is more effective than the Euclidean space for embedding graphs with tree-like structures. Thus, it is critical how to select the best dimensionality for the hyperbolic space in which a graph is embedded. This is because we cannot distinguish nodes well with dimensionality that is considerably low, whereas the embedded relations are affected by irregularities in data with excessively high dimensionality. We consider this problem from the viewpoint of statistical model selection for latent variable models. Thereafter, we propose a novel methodology for dimensionality selection based on the minimum description length principle. We aim to introduce a latent variable modeling of hyperbolic embeddings and apply the decomposed normalized maximum likelihood code-length to latent variable model selection. We empirically demonstrated the effectiveness of our method using both synthetic and real-world datasets.
Factors associated with non-carbapenemase mediated carbapenem resistance of Gram-negative bacteria: a retrospective case-control study
Authors: Müller Marius , Wiencierz Andrea , Gehringer Christian , Muigg Veronika , Bassetti Stefano , Siegemund Martin , Hinic Vladimira , Tschudin-Sutter Sarah , Egli Adrian 
Published: August 2023

AbstractInfections with carbapenemase-producing Gram-negative bacteria are related to increased morbidity and mortality, yet little is known regarding infections caused by non-beta-lactamase mediated carbapenem-resistant bacteria. Our objective was to identify risk factors for, and the clinical impact of infections caused by carbapenem-resistant carbapenemase-negative Enterobacterales and Pseudomonas aeruginosa. This retrospective matched case-control study was performed at the University Hospital of Basel, Switzerland, in 2016. We focused on other resistance mechanisms by excluding laboratory-confirmed carbapenemase-positive cases. Carbapenem resistance was set as the primary endpoint, and important risk factors were investigated by conditional logistic regression. The clinical impact of carbapenem resistance was estimated using regression models containing the resistance indicator as explanatory factor and adjusting for potential confounders. Seventy-five cases of infections with carbapenem-resistant, carbapenemase-negative bacteria were identified and matched with 75 controls with carbapenem-susceptible infections. The matched data set was well-balanced regarding age, gender, and comorbidity. Duration of prior carbapenem treatment (OR 1.15, [1.01, 1.31]) correlated with resistance to carbapenems. Our study showed that patients with carbapenem-resistant bacteria stayed 1.59 times (CI [0.81, 3.14]) longer in an ICU. The analyzed dataset did not provide evidence for strong clinical implications of resistance to carbapenems or increased mortality. The duration of prior carbapenem treatment seems to be a strong risk factor for the development of carbapenem resistance. The higher risk for a longer ICU stay could be a consequence of a carbapenem resistance. In contrast to carbapenemase-producers, the clinical impact of carbapenamase-negative, carbapenem-resistant strains may be limited. Trial registration: The study design was prospectively approved by the local Ethics Commission on 10.08.2017 (EKNZ BASEC 2017-00222).
Length of hospital stays and financial incentives: evidence from Dutch rehabilitation centers
Authors: Gaspar Katalin , Croes Ramsis , Mikkers Misja , Koolman Xander 
Published: August 2023

AbstractNon-linear reimbursement contracts in healthcare have been increasingly used to quantify providers’ responses to financial incentives. In the present research, we utilize a large one-off increase in the reimbursement of rehabilitation care to assess to what extent providers are willing to modify their treating behavior to maximize profits. In order to disincentivize the use of short inpatient stays for rehabilitation care, Dutch policy-makers have instated a two-part stepwise tariff-schedule. A lower tariff-schedule is applied for short hospital stays (≤ 14 days), while a higher tariff-schedule is utilized for longer treatments. Switching from one schedule to the other at day 15 of inpatient care leads to a sudden and large increase in tariffs. We show that, for most care-types, patients are seldom treated in an inpatient setting for less than 15 days, while the majority of patients are discharged after the threshold. Therefore, we conclude that the financial incentive at day 15 leads to considerable distortions in treatment. However, instead of discharging all patients at the threshold point where marginal tariffs are maximized, providers tend to continue treatment indicating altruistic behavior. As healthcare payment systems move away from piecewise reimbursement (e.g., fee-for-service arrangements), and services are increasingly ‘lumped’ together into e.g., DRGs and bundled payments, the likelihood of such discontinuities in tariff-schedules radically increases. Our research illustrates how such discontinuities in reimbursements can lead to distortions in the amount of healthcare provided contributing to the debate on optimal healthcare contracting design.
An update on mechanisms of pruritus and their potential treatment in primary cutaneous T-cell lymphoma
Authors: Hu Man , Scheffel Jörg , Elieh-Ali-Komi Daniel , Maurer Marcus , Hawro Tomasz , Metz Martin 
Published: August 2023

AbstractPrimary cutaneous T-cell lymphomas (CTCL), which include mycosis fungoides (MF) and Sézary syndrome (SS), are a group of lymphoproliferative disorders characterized by clonal accumulation of neoplastic T-lymphocytes in the skin. Severe pruritus, one of the most common and distressing symptoms in primary CTCL, can significantly impair emotional well-being, physical functioning, and interpersonal relationships, thus greatly reducing quality of life. Unfortunately, effectively managing pruritus remains challenging in CTCL patients as the underlying mechanisms are, as of yet, not fully understood. Previous studies investigating the mechanisms of itch in CTCL have identified several mediators and their corresponding antagonists used for treatment. However, a comprehensive overview of the mediators and receptors contributing to pruritus in primary CTCL is lacking in the current literature. Here, we summarize and review the mediators and receptors that may contribute to pruritus in primary CTCL to explore the mechanisms of CTCL pruritus and identify effective therapeutic targets using the PubMed and Web of Science databases. Studies were included if they described itch mediators and receptors in MF and SS. Overall, the available data suggest that proteases (mainly tryptase), and neuropeptides (particularly Substance P) may be of greatest interest. At the receptor level, cytokine receptors, MRGPRs, and TRP channels are most likely important. Future drug development efforts should concentrate on targeting these mediators and receptors for the treatment of CTCL pruritus.