bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Rotational Thromboelastometry (ROTEM) on Clinical Course and Outcomes of COVID -19 Critically Ill Patients: A Retrospective Single Center Observational Study
Authors: Pazzi Maddalena , Conti Duccio , Tofani Lorenzo , Zanfino Lucantonio , Gemmi Eleonora , Pasquinelli Filippo , Frigieri Francesca Covani , Venni Angelica , Gianesello Lara , Carpi Roberto , Prisco Domenico , Marcucci Rossella , Pavoni Vittorio 
Published: January 2023

Abstract
BACKGROUND The severity of coagulation derangement correlates with poor prognosis in COVID-19 patients. However, the clinical impact of coagulation alterations detected with rotational thromboelastometry (ROTEM) in intensive care unit (ICU) COVID-19 patients is not completely defined. The study aimed to identify the correlation between ROTEM parameters and adverse ICU outcomes. The relationship between COVID-19 associated coagulopathy (CAC) and ROTEM alterations and possible risk factors for ICU mortality were also investigated.
METHODS COVID-19 patients admitted to ICU between October 1, 2020 and May 31, 2021, were retrospectively enrolled. The sample was subsequently divided into subgroups (survivors vs. non-survivors, mechanical ventilation (MV) vs. non-invasive ventilation (NIV), venous thromboembolism (VTE) vs. NO-VTE, CAC vs. NO-CAC) among which ROTEM parameters and standard coagulation tests were compared.
RESULTS One hundred ICU patients were enrolled. High D-dimer (DD) (5089 ± 1035 ng/ml) and fibrinogen levels (640 ± 112 mg/dl) and an increase in maximum clot firmness (MCF) were revealed. The non-survivors (n=50, 50%) had higher DD levels and lower platelet counts as well as lower clot lysis rates than survivors. EXTEM maximum lysis (ML) resulted lower in the MV subgroup than in NIV treated patients. Patients with thrombotic complications had higher DD levels than patients without VTE whereas ROTEM parameters were not different. Similarly no coagulation or ROTEM differences were identified in the subgroup of CAC patients (n=29, 29%). Reduced ML values in EXTEM and INTEM resulted as possible risk factors for ICU mortality.
CONCLUSIONS In critically ill COVID-19 patients, hypofibrinolysis and not hypercoagulability seems to be correlated with unfavourable ICU prognosis.
Son’s contribution to mother’s fitness can overcome the twofold cost of sex
Authors: Yasui Yukio , Hasegawa Eisuke 
Published: January 2023

Abstract
Sexual reproduction requires mating partners and transmits only half of their genomes to an offspring1,2. However, because the sex-controlling allele is fixed at the origin of gametic sex, where each gamete provided half amount of necessary resource (isogamy), the genome dilution cost disappears3. In the traditional view1,2, derivative anisogamy (bipolarization into egg and sperm) must have half the population growth rate of asexual thelytoky because males laying no eggs are not included in population size1,2. The present dominance of anisogamy despite this "twofold cost of male production" is the greatest enigma in evolutionary biology1,2,4-6. Sex has various advantages6-27, but none overcome this cost22. Why can anisogamy become dominant? Here, we show that a son's mating with multiple females contributes to his mother's fitness. Although only females contribute egg resources in anisogamy, at the lineage level, males from a particular lineage parasitize the egg resources of the other lineages, and their own lineage's eggs are fertilized by sperm from the other lineages. Considering it reciprocal altruism between lineages, anisogamy can offset male-production costs by yielding more grandchildren than thelytoky. Our simulations prove that anisogamy is evolutionarily stable against isogamy and thelytoky. The significance of males, a question since Aristotle's time, is clearly answered.
Population dynamics and infestation level of Tetranychus evansi Baker and Pritchard, 1960 (Acari: Tetranychidae) over two tomato planting seasons in Burkina Faso
Authors: Drabo E. , Traoré F. , Waongo A. , Dabiré-Binso L. C. , Sanon A. 
Published: January 2023

Abstract

Tetranychus evansi is an invasive pest of Solanaceae in West Africa. It causes severe damage and economic losses in tomato production. This study, conducted in four sites (Loumbila, Ouagadougou, Pabré and Tanghin-Dassouri) in the central zone of Burkina Faso, assessed the density of T. evansi over two growing seasons and evaluated the infestation levels through the tomato growth cycle from planting up to harvest. Mite’s population was assessed weekly from March to May during the dry season and from August to October for the rainy season in Burkina Faso. We found a high density of T. evansi during the hot and dry periods corresponding to increase temperatures. The Loumbila, Pabré, and Tanghin-Dassouri sites show a similar density of the mite’s population and generally have an average of fewer than 20 individuals per leaf compared to the site in Ouagadougou with a density of more than 80 individuals per leaf. In contrast, during the rainy season, which is characterized by high humidity, densities of T. evansi were as low as 10 individuals per leaf. We also found that, when climatic and environmental conditions are favorable, all growth stages of the tomato are attacked by the pest. As producers face many difficulties to control T. evansi, there is an urgent need to implement an integrated pest management strategy against this pest.
Ginseng intake and Alzheimer disease-specific cognition in older adults according to apolipoprotein ε4 allele status
Authors: Lee Boung Chul , Choe Young Min , Suh Guk-Hee , Choi Ihn-Geun , Kim Hyun Soo , Hwang Jaeuk , Yi Dahyun , Jhoo Jin Hyeong , Kim Jee Wook 
Published: January 2023

Abstract
Background
The probable association among ginseng intake, Alzheimer’s disease (AD)-specific cognition, and apolipoprotein ε4 (APOE4) remains poorly investigated. Hence, we examined the association between ginseng intake and AD-specific cognition in older adults under the moderating effect of APOE4.
Methods
This study enrolled 139 adults aged 65–90 years without dementia. All participants underwent comprehensive dietary and clinical assessments including ginseng intake, AD-related cognition (i.e., delayed episodic memory, as the earliest cognitive change in AD), and non-memory cognition for comparative purposes.
Results
Ginseng intake was associated with higher delayed episodic memory, but not non-memory cognition, compared to no ginseng intake. The interaction between ginseng intake and APOE4 had a significant effect on delayed episodic memory. Subgroup analyses showed that ginseng intake was associated with higher delayed episodic memory in the APOE4-negative but not the APOE4-positive subgroup. The benefits of ginseng intake on delayed episodic memory were prominent in the high duration (≥ 5 years) and midlife onset (< 65 years) groups.
Conclusions
Our study of older adults with no dementia suggests that ginseng intake (with high duration and midlife onset) had a beneficial effect on AD-specific cognitive decline, i.e., the delayed episodic memory. In addition, APOE4 moderates the association between ginseng intake status and AD-specific cognitive decline.
Long-term daily hydrometeorological drought indices, soil moisture, and evapotranspiration for ICOS sites
Authors: Pohl Felix , Rakovec Oldrich , Rebmann Corinna , Hildebrandt Anke , Boeing Friedrich , Hermanns Floris , Attinger Sabine , Samaniego Luis , Kumar Rohini 
Published: January 2023

Abstract
Eddy covariance sites are ideally suited for the study of extreme events on ecosystems as they allow the exchange of trace gases and energy fluxes between ecosystems and the lower atmosphere to be directly measured on a continuous basis. However, standardized definitions of hydroclimatic extremes are needed to render studies of extreme events comparable across sites. This requires longer datasets than are available from on-site measurements in order to capture the full range of climatic variability. We present a dataset of drought indices based on precipitation (Standardized Precipitation Index, SPI), atmospheric water balance (Standardized Precipitation Evapotranspiration Index, SPEI), and soil moisture (Standardized Soil Moisture Index, SSMI) for 101 ecosystem sites from the Integrated Carbon Observation System (ICOS) with daily temporal resolution from 1950 to 2021. Additionally, we provide simulated soil moisture and evapotranspiration for each site from the Mesoscale
Hydrological Model (mHM). These could be utilised for gap-filling or long-term research, among other pplications. We validate our data set with measurements from ICOS and discuss potential research avenues.
Association Between Purchase of Over-the-Counter Medications and Ovarian Cancer Diagnosis in the Cancer Loyalty Card Study (CLOCS): Observational Case-Control Study
Authors: Brewer Hannah R , Hirst Yasemin , Chadeau-Hyam Marc , Johnson Eric , Sundar Sudha , Flanagan James M 
Published: January 2023

Background
Over-the-counter (OTC) medications are frequently used to self-care for nonspecific ovarian cancer symptoms prior to diagnosis. Monitoring such purchases may provide an opportunity for earlier diagnosis.

Objective
The aim of the Cancer Loyalty Card Study (CLOCS) was to investigate purchases of OTC pain and indigestion medications prior to ovarian cancer diagnosis in women with and without ovarian cancer in the United Kingdom using loyalty card data.

Methods
An observational case-control study was performed comparing purchases of OTC pain and indigestion medications prior to diagnosis in women with (n=153) and without (n=120) ovarian cancer using loyalty card data from two UK-based high street retailers. Monthly purchases of pain and indigestion medications for cases and controls were compared using the Fisher exact test, conditional logistic regression, and receiver operating characteristic (ROC) curve analysis.

Results
Pain and indigestion medication purchases were increased among cases 8 months before diagnosis, with maximum discrimination between cases and controls 8 months before diagnosis (Fisher exact odds ratio [OR] 2.9, 95% CI 2.1-4.1). An increase in indigestion medication purchases was detected up to 9 months before diagnosis (adjusted conditional logistic regression OR 1.38, 95% CI 1.04-1.83). The ROC analysis for indigestion medication purchases showed a maximum area under the curve (AUC) at 13 months before diagnosis (AUC=0.65, 95% CI 0.57-0.73), which further improved when stratified to late-stage ovarian cancer (AUC=0.68, 95% CI 0.59-0.78).

Conclusions
There is a difference in purchases of pain and indigestion medications among women with and without ovarian cancer up to 8 months before diagnosis. Facilitating earlier presentation among those who self-care for symptoms using this novel data source could improve ovarian cancer patients’ options for treatment and improve survival.

Trial Registration
ClinicalTrials.gov NCT03994653; https://clinicaltrials.gov/ct2/show/NCT03994653
The European Bone and Joint Infection Society definition of periprosthetic joint infection is meaningful in clinical practice: a multicentric validation study with comparison with previous definitions
Authors: Sousa Ricardo , Ribau Ana , Alfaro Pedro , Burch Marc-Antoine , Ploegmakers Joris , McNally Martin , Clauss Martin , Wouthuyzen-Bakker Marjan , Soriano Alex 
Published: January 2023

Background and purpose: A new periprosthetic joint infection (PJI) definition has recently been proposed by the European Bone and Joint Infection Society (EBJIS). The goals of this paper are to evaluate its diagnostic accuracy and compare it with previous definitions and to assess its accuracy in preoperative diagnosis.Patients and methods: We retrospectively evaluated a multicenter cohort of consecutive revision total hip and knee arthroplasties. Cases with minimum required diagnostic workup were classified according to EBJIS, 2018 International Consensus Meeting (ICM 2018), Infectious Diseases Society of America (IDSA), and modified 2013 Musculoskeletal Infection Society (MSIS) definitions. 2 years’ minimum follow-up was required to assess clinical outcome.Results: Of the 472 cases included, PJI was diagnosed in 195 (41%) cases using EBJIS; 188 (40%) cases using IDSA; 172 (36%) using ICM 2018; and 145 (31%) cases using MSIS. EBJIS defined fewer cases as intermediate (5% vs. 9%; p = 0.01) compared with ICM 2018. Specificity was determined by comparing risk of subsequent PJI after revision surgery. Infected cases were associated with higher risk of subsequent PJI in every definition. Cases classified as likely/confirmed infections using EBJIS among those classified as not infected in other definitions showed a significantly higher risk of subsequent PJI compared with concordant non-infected cases using MSIS (RR = 3, 95% CI 1–6), but not using ICM 2018 (RR = 2, CI 1–6) or IDSA (RR = 2, CI 1–5). EBJIS showed the highest agreement between pre-operative and definitive classification (k = 0.9, CI 0.8–0.9) and was better at ruling out PJI with an infection unlikely result (sensitivity 89% [84–93], negative predictive value 90% [85–93]).Conclusion: The newly proposed EBJIS definition emerged as the most sensitive of all major definitions. Cases classified as PJI according to the EBJIS criteria and not by other definitions seem to have increased risk of subsequent PJI compared with concordant non-infected cases. EBJIS classification is accurate in ruling out infection preoperatively.
Lääkärin vai potilaan taitoa? Suomea toisena kielenä puhuvan lääkärin puheen ymmärrettävyys vastaanottotilanteessa
Authors: Pitkänen Taina , Tervola Maija 
Published: January 2023

Artikkeli käsittelee suomea toisena kielenä käyttävien lääkäreiden puheen ymmärrettävyyttä vastaanottotilanteessa. Tutkimusaineistona on EU/ETA-maiden ulkopuolella tutkintonsa suorittaneiden lääkäreiden laillistamisprosessiin kuuluvia potilastenttejä, eli videoituja potilasvastaanottoja, joiden yhteiskesto on noin 40 tuntia.
Artikkelissa tarkastellaan lääkärin puheen ymmärrettävyyttä kahdesta näkö-kulmasta. Ensin tutkitaan kohtia, joissa potilas jotenkin ilmaisee, että ei ole ymmärtänyt lääkärin puhetta. Analyysin toisessa osassa huomio kohdistetaan kielellisten merkitysten välittymiseen ja pyritään selvittämään, mitkä puheen ominaisuudet heikentävät ymmärrettävyyttä.
Tutkimuksesta ilmeni, että potilaan ilmaisemat ongelmat liittyvät usein ääntämiseen ja morfosyntaksiin. Jonkin verran vähemmän on sanastoon ja kieliopillisiin merkityksiin liittyviä ongelmia. Nämä ongelmat ovat usein paikallisia ja ratkeavat tilanteen kuluessa. Analyysin toinen vaihe toi esiin vakavampia ongelmia: sanastopuutteita ja epätäsmällisiä tai suorastaan vääriä kieliopillisia merkityksiä, jotka estävät viestin välittymisen täsmällisesti. Samalla kävi ilmi, että potilaiden kesken on suuria eroja siinä, miten hyvin he ymmärtävät suomea toisena kielenä puhuvan lääkärin puhetta.
School Leadership and Management Role in Supporting ODL Student Teachers in the Secondary School-Based Post Graduate Diploma in Education Program
Authors: Hadebe LillieBeth 
Published: January 2023

Open and Distance Learning (ODL) student teachers, like all student teachers of the century, during their teacher preparation course, do engage in direct practice in the schools. This exercise is done under the tutelage of the university, school leadership and qualified teachers. It is during this direct practice that student teachers need support services, not only from their university, but from the school community. The study sought to establish prevention, intervention, transition and follow up support services offered by secondary school administrators to students on a Post Graduate Diploma in Education program during teaching practice. This was necessitated by the realization that as student teachers sought to get professionalized through improved pedagogical skills and personal growth during teaching practice, they needed relevant and effectively executed support services from their school administrators. Mixed research methodology was used, and purposive sampling was employed to identify the study participants. The perceptions of both heads and student teachers were gathered through questionnaires and interviews. The findings of the study revealed that effective and relevant student support services could only be achieved through nurturing of positive relationships between the student teacher and the head; a difficult concept to achieve when the head’s concentration was more on administrative tasks than on curricular and instructional tasks.
Deteksi Dini Penyakit Jantung dan Pembuluh Darah Pegawai
Authors: Umara Annisaa Fitrah , Nuraini Nuraini , Ahmad Shieva Nur Azizah , Habibi Alpan , Nainar Azizah Al Ashri , Hastuti Kartini, Hera , Purnamasari Elly , Yoyoh Imas , Irawati Popy , Latipah Siti , Wibisana Elang 
Published: January 2023

Prevalensi penyakit jantung dan pembuluh darah di Indonesia terus meningkat berdasarkan umur. Selain umur, faktor risiko penyakit jantung dilihat dari kadar kolesterol, diabetes mellitus, berat badan, dan hipertensi. Menurut data awal, rata-rata umur pegawai di SMA Negeri Kota Tangerang berada pada rentang umur yang memiliki risiko penyakit jantung dan pembuluh darah. Pengabdian masyarakat ini bertujuan untuk mengetahui faktor risiko penyakit jantung dan pembuluh darah melalui anamnesis, pemeriksaan tekanan darah, kadar gula darah, kolesterol, tinggi dan berat badan, serta Indeks Massa Tubuh (IMT). Metode dengan anamnesis dan pemeriksaan kesehatan dilakukan pada 42 orang peserta dalam satu waktu menggunakan skrining Jakarta Cardiovascular Score. Hasil anamnesis dan pemeriksaan kesehatan yaitu mayoritas peserta adalah perempuan berumur 50-54 tahun, 12 orang mengalami hipertensi, 20 orang dengan IMT berlebih, mayoritas tidak ada riwayat merokok dan diabetes mellitus. Sebanyak 14 orang dengan kolesterol ≥200 mg/dl dan mayoritas peserta tidak melakukan latihan fisik. Mayoritas peserta memiliki faktor risiko tinggi mengalami penyakit jantung dan pembuluh darah berdasarkan hasil deteksi dini menggunakan Jakarta Cardiovascular Score. Dibutuhkan intervensi lanjut berupa edukasi mengenai pola hidup sehat dan pencegahan hipertensi seperti pengukuran tekanan darah secara rutin. Kata kunci: Deteksi dini, faktor risiko, penyakit jantung dan pembuluh darah.
Pemberdayaan Orang Hidup dengan HIV melalui Peningkatan Pengetahuan dan Keterampilan Kerajinan Tangan
Authors: Ibrahim Kusman , Ermiati Ermiati , Rahayu Urip , Rahayuwati Laili , Komariah Maria 
Published: January 2023

Orang hidup dengan HIV (ODHIV) tidak jarang menghadapi stigma dan diskriminasi dari keluarga, masyarakat, bahkan tenaga kesehatan yang menyebabkan mereka terkendala mendapatkan akses terhadap layanan kesehatan, pekerjaan, dan fasilitas sosial kemasyarakatan lainnya. Hal ini menyebabkan ODHIV tidak berdaya dan masalah-masalah kesehatan yang dihadapinya jadi sulit untuk diatasi. Tujuan dari pengabdian masyarakat ini adalah untuk memberdayakan ODHIV melalui peningkatan pengetahuan dan keterampilan hidup agar bisa menjalani hidup sehat, produktif, dan berkualitas. Metode yang digunakan dalam kegiatan ini adalah pemberdayaan masyarakat melalui pelatihan partisipatif dan pendampingan. Khalayak sasaran yaitu para ODHIV, pendamping, dan aktivis LSM di bawah pembinaan KPA Sumedang dan Puskesmas Situ sejumlah 17 orang. Hasil terdapat peningkatan persentase kategori pengetahuan tinggi (11,7% ke 88,3%) dan rerata pengetahuan (73,53 ke 82,94) secara bermakna (p < 0.05). Peserta menunjukkan antusiasme dan mampu mendemonstrasikan pembuatan kerajinan tangan tas dari bahan bekas bungkus kipi. Peserta menunjukkan antusiasme dan mampu mendemonstrasikan pembuatan kerajinan tangan tas dari bahan bekas bungkus kipi. Kegiatan ini perlu ditindaklanjuti dengan mengintegrasikan gerakan berbasis masyarakat dan budaya yang sudah ada seperti “rampak polah”, dan dimasukan ke salah satu program pemberdayaan masyarakat dibawah koordinasi Komisi Penanggulangan AIDS dan Pemerintah Daerah Kabupaten Sumedang bekerjasama dengan Perguruan Tinggi setempat. Kata kunci : Keterampilan, ODHIV, pemberdayaan, pengetahuan.
Pemanfaatan Bio-Slurry Mengurangi Dampak terhadap Pencemaran Lingkungan bagi Kesehatan Masyarakat
Authors: Sutanto J.E. , Kristama Baswara Yua , Purwoko Gervasius Herry , Harnawan Bagus Yossy , Dewi Intan Suksma , Fadilah Hana Faizah , Wicaksono Adityo Tri , Handriyanto Rachmanu Eko , Kusuma Maritha Nilam 
Published: January 2023

Tujuan pelaksanaan kegiatan pengabdian kepada masyarakat, akan mengurangi adanya faktor terjadinya dampak pencemaran lingkungan yang berpengaruh bagi kesehatan masyarakat di Dusun Pengajaran. Faktanya selama ini masih banyak masyarakat yang belum mengetahui dampak pencemaran lingkungan bagi kesehatan. Oleh karena itu tim pelaksana mencari alternatif sebagai solusinya yaitu tim pelaksana memberikan pelatihan bagi masyarakat Dusun Pengajaran bagaimana pemanfaatan bio-slurry dijadikan briket. Metode pelaksanaannya yaitu tim pelaksana memberikan pelatihan pembuatan briket dan selain itu masyarakat juga diberikan mesin pembuat briket, dengan demikian langsung melakukan praktek proses produksi briket. Mesin pembuat briket tersebut ini juga sangat mudah dalam pengoperasiannya, aman dan juga sangat praktis. Hasil pelaksanaan kegiatan pengabdian masyarakat terkait pemanfaatan bio-slurry untuk mengurangi dampak terhadap pencemaran lingkungan dan juga bagi kesehatan masyarakat, namun menjadi tantangan dan sekaligus manfaat serta keuntungan bagi masyarakat yaitu bahwa briket bisa digunakan sebagai salah satu usaha di tengah kondisi harga gas LPG yang relatif tidak murah dan cenderung terus naik dan minyak tanah yang semakin langkah didapat, saat sekarang ini beberapa orang mulai mempertimbangkan menggunakan bahan bakar alternatif. Penggunaan briket menjadi salah satu solusi yang tepat dan banyak dipilih sebagian besar masyarakat untuk keluar dari permasalahan tersebut. Secara tidak langsung fenomena ini turut membuka peluang usaha yang cukup menjanjikan, sehingga secara ekonomi akan meningkatkan pendapatan masyarakat dan pada akhirnya kesehatan bagi masyarakat di Dusun Pengajaran tetap tidak terabaikan. Kata kunci: Pencemaran lingkungan, kesehatan bagi masyarakat, briket, bio-slurry.
Pemberdayaan Orang Tua dalam Literasi Digital Berbasis Aplikasi Iposyandu untuk Memantau Tumbuh Kembang Balita
Authors: Didah Didah , Susanti Ari Indra , Sari Atriany Nilam , Ruluwedrata Fedri Rinawan 
Published: January 2023

Tantangan dalam perubahan teknologi di Era Revolusi Industri 4.0 turut memengaruhi kebutuhan masyarakat terutama dalam aspek kesehatan. Akses informasi kesehatan diharapkan dapat diperoleh dengan mudah dan cepat. Aplikasi iPosyandu merupakan salah satu solusi dari harapan tersebut karena aplikasi iPosyandu merupakan media orang tua untuk memantau kondisi pertumbuhan dan perkembangan anaknya berbasis android. Adapun tujuan kegiatan pengabdian masyarakat ini diharapkan mampu memberdayakan orang tua dengan penggunaan literasi digital berbasis aplikasi iPosyandu untuk memantau tumbuh kembang balita. Kegiatan pengabdian masyarakat ini turut menilai kepuasan orang tua dalam penggunaan aplikasi iPosyandu orang tua berdasarkan dimensi kemudahan, tampilan dan kepuasan, serta penggunaan. Penilaian kepuasan tersebut dengan memberikan kuesioner setelah pelatihan online melalui Group WhatsApp. Desain penelitian yang digunakan adalah Observational dengan studi deskriptif dengan pendekatan cross sectional adapun sampel pada kegiatan pengabdian masyarakat ini adalah sebanyak 54 ibu yang memiliki balita yang berumur 0-59 bulan serta tehnik pengambilan sampel dalam penelitian ini yaitu purposive sampling. Hasil kegiatan PKM ini menunjukkan bahwa 57,4% dari responden menyetujui bahwa aplikasi iPosyandu orang tua menyediakan cara yang mudah dalam menerima pelayanan kesehatan, memperoleh edukasi kesehatan, memantau kegiatan dan melakukan penilaian secara mandiri. Simpulan dalam kegiatan ini yakni aplikasi iPosyandu orang tua mampu meningkatkan kemampuan literasi digital dan pemanfaatan penggunaan teknologi dalam kesehatan. Kata kunci: Aplikasi iPosyandu, literasi digital, orang tua.