bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrically Switchable Polarization in Bi2O2Se Ferroelectric Semiconductors
Authors: Wang Weijun , Meng You , Zhang Yuxuan , Zhang Zhuomin , Wang Wei , Lai Zhengxun , Xie Pengshan , Li Dengji , Chen Dong , Quan Quan , Yin Di , Liu Chuntai , Yang Zhengbao , Yip SenPo , Ho Johnny C. 
Published: January 2023

AbstractAtomically 2D layered ferroelectric semiconductors, in which the polarization switching process occurs within the channel material itself, offer a new material platform that can drive electronic components toward structural simplification and high‐density integration. Here, a room‐temperature 2D layered ferroelectric semiconductor, bismuth oxychalcogenides (Bi2O2Se), is investigated with a thickness down to 7.3 nm (≈12 layers) and piezoelectric coefficient (d33) of 4.4 ± 0.1 pm V−1. The random orientations and electrically dependent polarization of the dipoles in Bi2O2Se are separately uncovered owing to the structural symmetry‐breaking at room temperature. Specifically, the interplay between ferroelectricity and semiconducting characteristics of Bi2O2Se is explored on device‐level operation, revealing the hysteresis behavior and memory window (MW) formation. Leveraging the ferroelectric polarization originating from Bi2O2Se, the fabricated device exhibits “smart” photoresponse tunability and excellent electronic characteristics, e.g., a high on/off current ratio > 104 and a large MW to the sweeping range of 47% at VGS = ±5 V. These results demonstrate the synergistic combination of ferroelectricity with semiconducting characteristics in Bi2O2Se, laying the foundation for integrating sensing, logic, and memory functions into a single material system that can overcome the bottlenecks in von Neumann architecture.
A Potential‐Based Boundary Element Implementation for Modeling Multiple Scattering from Local and Nonlocal Plasmonic Nanowires
Authors: Mystilidis Christos , Zheng Xuezhi , Xomalis Angelos , Vandenbosch Guy A. E. 
Published: January 2023

AbstractA novel boundary element implementation that models multiple scattering of plasmonic nanowires is presented. The modeling is based on potentials and the materials constituting the wires can be local (described by the local response model) or nonlocal (described by the nonlocal hydrodynamic model). The nonlocal hydrodynamic model (HDM) provides an important approximation describing nonclassical effects associated with the collective motion of free electrons in metals. The modeling is challenging as different interface conditions are needed at a boundary which separates 1) a local medium from a local medium; 2) a local (nonlocal) medium from a nonlocal (local) medium; and 3) a nonlocal medium from a nonlocal medium. The algorithm can address constructs of arbitrary geometry and material composition within the HDM; thus, it becomes a complete numerical tool for exploration of nonlocal nanowires. Fictitious sources are imposed at the boundaries, linking the scattered fields to the imposed sources, and matching the interface conditions at the boundaries. This procedure yields a set of Boundary Integral Equations (BIEs). Then, the BIEs are numerically solved utilizing the Boundary Element Method (BEM). The results from the BEM solver are verified quantitatively and qualitatively showing good agreement in both the near‐ and the far‐field regimes.
Mass Spectrometry Reveals High Levels of Hydrogen Peroxide in Pancreatic Cancer Cells
Authors: Liu Qinlei , Ge Wenjie , Martínez‐Jarquín Sandra , He Yuliang , Wu Ri , Stoffel Markus , Zenobi Renato 
Published: January 2023

AbstractReactive oxygen species (ROS) are critical for many cellular functions, and dysregulation of ROS involves the development of multiple types of tumors, including pancreatic cancer. However, ROS have been grouped into a single biochemical entity for a long time, and the specific roles of certain types of ROS in tumor cells (e.g., pancreatic ductal adenocarcinoma (PDAC)) have not been systematically investigated. In this work, a highly sensitive and accurate mass spectrometry‐based method was applied to study PDAC cells of humans and of genetically modified animals. The results show that the oncogenic KRAS mutation promotes the accumulation of hydrogen peroxide (H2O2) rather than superoxide or hydroxyl radicals in pancreatic cancer cells. We further identified that the enriched H2O2 modifies cellular metabolites and promotes the survival of pancreatic cancer cells. These findings highlight the specific roles of H2O2 in pancreatic cancer development, which may provide new directions for pancreatic cancer therapy.
Modulating Thermal Properties of Polymers through Crystal Engineering
Authors: Germann Luzia S. , Carlino Elvio , Taurino Antonietta , Magdysyuk Oxana V. , Voinovich Dario , Dinnebier Robert E. , Bučar Dejan‐Krešimir , Hasa Dritan 
Published: January 2023

AbstractCrystal engineering has exclusively focused on the development of advanced materials based on small organic molecules. We now demonstrate how the cocrystallization of a polymer yields a material with significantly enhanced thermal stability but equivalent mechanical flexibility. Isomorphous replacement of one of the cocrystal components enables the formation of solid solutions with melting points that can be readily fine‐tuned over a usefully wide temperature range. The results of this study credibly extend the scope of crystal engineering and cocrystallization from small molecules to polymers.
Boron‐Centered Lewis Superacid through Redox‐Active Ligands: Application in C−F and S−F Bond Activation
Authors: Köring Laura , Stepen Arne , Birenheide Bernhard , Barth Simon , Leskov Maxim , Schoch Roland , Krämer Felix , Breher Frank , Paradies Jan 
Published: January 2023

AbstractA series of redox‐responsive ferrocenyl‐substituted boranes and boronic esters were synthesized. Oxidation of the ferrocenyl ligand to the ferrocenium resulted in a drastic increase in the Lewis acidity beyond the strength of SbF5, which was investigated experimentally and computationally. The resulting highly Lewis acidic boron compounds were used for catalytic C−F and S−F bond activation.
Integrating Chemical Pre‐Potassiation with Pre‐Modulated KF‐Rich Electrolyte Interfaces for Dual‐Carbon Potassium Ion Hybrid Capacitor
Authors: Qian Yong , Wu Bei , Li Yang , Pan Zhen , Feng Shuai , Lin Ning , Qian Yitai 
Published: January 2023

AbstractHerein, a chemical pre‐potassiation strategy via simultaneously treating both glucose derived carbon (GDC) anode and commercial activated carbon (CAC) cathode in potassium‐naphthalene‐tetrahydrofuran solution is developed for potassium ion hybrid capacitor (PIHC). Combined with in situ and ex situ characterizations, a radical reaction between pre‐potassiation reagent and carbon electrodes is confirmed, which not only deactivates electrochemical irreversible sites, but also promotes to pre‐form a uniform and dense KF‐rich electrolyte film on the electrodes. As a result, the pre‐potassiation treatment presents multiple advantages: (I) the initial Coulombic efficiency (CE) of the GDC anode increases from 45.4 % to 84.0 % with higher rate capability; (II) the CAC cathode exhibits the improved cycling CEs and stability due to the enhanced resistance to electrolyte oxidation at 4.2 V; (III) the assembled PIHC achieves a high energy density of 172.5 Wh kg−1 with cycling life over 10000 cycles.
Supratherapeutic dabigatran: a cause of life‐threatening haemorrhage*
Authors: Hennessy M. , Reidy B. , Ní Ainle F. , Conneely J. , McDermott C. , Scanaill P. Ó. 
Published: January 2023

SummaryIn this case report, we present a rare case of life‐threatening gastrointestinal haemorrhage associated with deranged coagulation due to supratherapeutic levels of dabigatran. Dabigatran is a potent, synthetic, reversible non‐peptide thrombin inhibitor which is increasingly used for stroke prevention in patients with non‐valvular atrial fibrillation. It is generally accepted that dabigatran dosing does not require titration or the monitoring of plasma levels due to its predictable pharmacokinetics and pharmacodynamics. However, this case report challenges this viewpoint while identifying an important knowledge gap in relation to the effect of altered gastrointestinal motility on the absorption of direct oral anticoagulants. Furthermore, it demonstrates the successful use of high‐dose idarucizumab in a critical care setting. Idarucizumab is a monoclonal antibody fragment that binds specifically to dabigatran and its metabolites, thereby reversing the anticoagulant effect.
Inclusion of cross‐sectional and radiological images for better understanding of musculoskeletal anatomy and decreasing the risk of adverse events during dry needling in undergraduate physiotherapy students
Authors: Valera‐Calero Juan Antonio , Navarro‐Santana Marcos José , Fernández‐de‐las‐Peñas César , Varol Umut , López‐de‐Uralde‐Villanueva Ibai , Rodríguez‐López Elena Sonsoles , Plaza‐Manzano Gustavo 
Published: January 2023

AbstractSince there is an increasing rate of physiotherapists using invasive procedures during the clinical practice, understanding the cross‐sectional anatomy and radiological images is essential for ensuring patients' safety during these interventions. Therefore, the aim of this study was to analyze the students' opinion of including cross‐sectional and radiological images to traditional methodologies, to evaluate whether these additional resources improve their ability to identify musculoskeletal structures in radiological images and their understanding of neurovascular and visceral structures related with specific muscles to be avoided during invasive procedures. First‐year undergraduate physiotherapy students were enrolled in the study. A brief online survey asking about their opinion about the use of cross‐sectional and radiological images as complementary resources was built. In addition, two open‐answer tests (before and after the inclusion of these resources) were conducted to evaluate their ability to identify correctly musculoskeletal structures in magnetic resonance and ultrasound images and to evaluate their awareness of high‐risk structures related with specific muscles. One‐hundred‐thirty‐two students returned the online survey and one‐hundred‐forty‐eight completed all the tests. In general, students opined cross‐sectional images to be of utility for learning anatomy (81.8%) and radiological images (93.9%) and felt they benefited from cross‐sectional and ultrasound images (78.0%). All tests showed significant improvements after the inclusion of these complementary resources (all,p < 0.001) except for trunk structures in MRI (p = 0.777). The implementation of anatomical cross‐sectional and radiological images resulted in better understanding of radiological images and better cognition of possible risk during invasive procedures.
Phase 1 study of DS‐1205c combined with gefitinib for EGFR mutation‐positive non‐small cell lung cancer
Authors: Goto Koichi , Shiraishi Yoshimasa , Murakami Haruyasu , Horinouchi Hidehito , Toyozawa Ryo , Takeda Masayuki , Uno Makiko , Crawford Nigel , McGill Joseph , Jimbo Takeshi , Ishigami Masato , Takayama Gensuke , Nakayama Shintaro , Ohwada Shoichi , Nishio Makoto 
Published: January 2023

AbstractBackgroundTyrosine kinase inhibitors (TKIs) are effective for the treatment of non‐small cell lung cancer (NSCLC) patients with activating mutations of the epidermal growth factor receptor (EGFR), but responses are not durable as tumors develop resistance. DS‐1205c is a novel, specific, orally bioavailable, small‐molecule AXL receptor TKI. In preclinical studies, DS‐1205c restored TKI antitumor activity in a TKI acquired‐resistance EGFR‐mutant NSCLC tumor xenograft model.MethodsThis first‐in‐human, multicenter, open‐label Phase 1 study (registered at ClinicalTrials.gov: NCT03599518) primarily evaluated the safety and tolerability of combination therapy with DS‐1205c and gefitinib in Japanese patients with metastatic or unresectable EGFR‐mutant NSCLC and tumor progression during treatment with EGFR‐TKIs. Patients (n = 20) received DS‐1205c monotherapy (200–1200 mg twice daily [BID]) in a 7‐day safety monitoring period before combination DS‐1205c/gefitinib (250 mg once daily) in 21‐day cycles.ResultsThe observed common treatment‐emergent adverse events (TEAEs) were increased aspartate aminotransferase (35%), increased alanine aminotransferase (30%), rash maculo‐papular (30%), and diarrhea (25%). No serious TEAEs were reported. Plasma concentrations and pharmacokinetic parameters of DS‐1205a (free form of DS‐1205c) were unaffected by concomitant administration of gefitinib. No patient achieved a complete or partial response and 5 patients (25%) had stable disease.ConclusionDS‐1205c was generally safe and well tolerated at all dose levels, but the safety profile of ≤800 mg BID was more favorable than 1200 mg BID. The recommended dose for dose‐expansion cohorts of DS‐1205c in combination therapy with gefitinib was 800 mg BID.
Diagnosis of cancer in the Emergency Department: A scoping review
Authors: Delamare Fauvel Alix , Bischof Jason J. , Reinbolt Raquel E. , Weihing Veronica K. , Boyer Edward W. , Caterino Jeffrey M. , Wang Henry E. 
Published: January 2023

AbstractBackgroundThe Emergency Department (ED) plays a key role in the identification and care of acute medical conditions, including cancer. In this scoping review, we aimed to determine the role of the ED in the acute diagnosis of cancer.MethodsWe conducted a scoping review of articles according to Preferred Reporting Items for Systematic Review and Meta‐Analyses (PRISMA) using PubMed and Google Scholar. We screened studies of adults with a new diagnosis of cancer in the ED. We included randomized control trials, prospective, retrospective, and cross‐sectional observational studies, and case reports published in English since 2000. We grouped the articles into categories based on their objectives and findings.ResultsOf the 4459 articles, we included 47 in the review. The identified studies fell into three major categories: (1) studies describing the incidental diagnosis of cancer in the ED (n = 11, 23%), (2) studies characterizing the acute initial presentation of cancer in the ED (n = 19, 41%), and (3) studies describing the ED as a pathway to cancer diagnosis in the healthcare system (n = 17, 36%). Across the studies, cancer diagnoses in the ED were more likely in patients with higher comorbidities, occurred at later stages, and resulted in worse survival rates.ConclusionsThe ED plays a prominent role in the initial diagnosis of cancer. Efforts must be made to integrate the ED within the cancer care continuum.
Prognostic value of modified criteria for hydroxyurea resistance or intolerance in patients with high‐risk essential thrombocythemia
Authors: Park Young Hoon , Lee Sewon , Mun Yeung‐Chul , Park Dong Jin 
Published: January 2023

AbstractBackgroundRecognizing intolerance or resistance to hydroxyurea (HU), which is related to the high risk of a disease transformation and reduced survival in essential thrombocythemia (ET), is crucial to making a reasonable decision about second‐line therapy. We assessed the prognostic impact of the modified European LeukemiaNet (mELN) criteria used in a recent MAJIC‐ET trial by analyzing the incidence of resistance or intolerance to HU and the survival outcome compared with those of the ELN criteria.MethodsWe retrospectively compared the development of HU resistance or intolerance according to the ELN and mELN criteria for 148 high‐risk ET patients receiving HU between 2014 and 2018. The maximum tolerated dose for defining HU resistance was used in the mELN criteria.ResultsThe median age of patients was 65 years (range, 36–87), with a median follow‐up of 3.6 years (range, 1.1–6.4). Two thromboembolic events were observed during HU treatment. When applying the ELN criteria, 10 patients (6.9%) were resistant (n = 5 [3.4%]) or intolerant (n = 5 [3.4%]) to HU in comparison with 22 patients (15%, 14 [9.8%]) resistant and 8 [5.5%] intolerant when applying the mELN criteria. Transformation to myelofibrosis and acute myeloid leukemia occurred in 2 (1.4%) patients and 1 (0.7%) patient, respectively, as defined by the ELN criteria compared with 3 (2.1%) and 2 (1.4%) patients as defined by the mELN criteria. In multivariate analysis of transformation‐free survival, HU resistance defined by the mELN criteria but not the ELN criteria was an independent prognostic factor. In addition, HU resistance as defined by both sets of criteria was an independent risk factor for inferior overall survival. Intolerance of HU did not have any prognostic impact on survival.ConclusionsThe mELN criteria are useful for identifying high‐risk ET patients who might be eligible for second‐line therapy in practice, which should be validated in a prospective setting.
Pan‐cancer molecular analysis of EGFR large fragment deletion in the Asian population
Authors: Pu Jun , Guo Huannan , Yu Ruoying , Ou Qiuxiang , Bao Hua , Wu Xue , Tang Sanyuan , Chang Qingyong 
Published: January 2023

AbstractBackgroundLarge fragment deletion (LFD) of EGFR was associated with carcinogenesis in many types of cancers. However, the molecular features of EGFR‐LFD have not been studied in the Asian cancer population.MethodHere we retrospectively analyzed the targeted sequencing data from a large cancer database.ResultsEGFR‐LFD was detected at a frequency of 0.03% with EGFRvIII being the most frequently observed LFD. TERTp variants were identified in 60% of the cases. TP53 alterations (33%) were mutually exclusive with TERTp variants and coexisted with EGFR‐LFD in lung cancer and colorectal cancer. EGFR amplification (67%) and chromosome 10p deletion (53%) were the most focal‐level and arm‐level CNV in this cohort. EGFR exon2–17 skipping was found in the tumor tissue of one patient after progressing on osimertinib.ConclusionOur study provided valuable insights into the distribution and molecular characteristics of EGFR‐LFD, hoping to shed light on the treatment management for EGFR‐LFD carriers.
Pasting properties, baking quality, and starch digestibility of einkorn, emmer, spelt, and hard red spring wheat
Authors: Kulathunga Jayani , Simsek Senay 
Published: January 2023

AbstractBackground and ObjectivesHulled wheat species have been recognized as interesting raw materials to produce niche products. More research studies are necessary on the hulled wheat species' quality, processability, and functional and nutritional properties to develop novel food products. This study was conducted to evaluate the pasting properties, baking quality, and in vitro starch digestibility of hulled wheat species.FindingsSignificantly (p < .05) higher peak viscosity values were observed in spelt, while significantly (p < .05) higher final viscosity values were observed in einkorn. Results of the baking quality revealed that there are potential genotypes of spelt that can be used to make specialty bread with similar loaf characteristics as hard red spring wheat. Significantly (p < .05) higher slowly digestible starch content was found in einkorn, emmer, and spelt compared to hard red spring wheat.ConclusionsEinkorn, emmer, and spelt used in this study, differ from hard red spring wheat in terms of dough properties, baking quality, starch digestibility, and pasting properties.Significance and NoveltyThe results of this study made a detailed comparison between hulled wheat and modern bread wheat grown in North Dakota, therefore, results would be useful in breeding to develop and release new and improved lines of hulled wheat species.
A comprehensive overview of the electrochemical mechanisms in emerging alkali metal–carbon dioxide batteries
Authors: Lin Jiangfeng , Song Wanqing , Xiao Caixia , Ding Jingnan , Huang Zechuan , Zhong Cheng , Ding Jia , Hu Wenbin 
Published: January 2023

AbstractAlkali metal–carbon dioxide (Li/Na/K‐CO2) batteries are emerging electrochemical energy storage technologies in the context of the energy crisis and the urgent demand for carbon neutrality. Alkali metal–CO2batteries offer a new strategy for CO2fixation and utilization, and thus has been receiving considerable attention in recent years. Considerable progress has been achieved since alkali metal–CO2batteries were invented, especially in terms of development of new electrode materials, and yet, research is lacking on the underlying mechanisms of the systems. This is the first typical review focusing on the electrochemical mechanisms of metal–CO2batteries that summarizes the current understanding of and provides insights into the thermodynamic reaction pathways, the kinetic characteristics, and the crucial factors determining the reaction mechanisms in alkali metal–CO2batteries. The review starts with the fundamental concepts of alkali metal–CO2batteries, followed by a comprehensive discussion of the working mechanisms on cathodes and anodes. Moreover, the operation mechanisms of state‐of‐the‐art electrolytes, including liquid and (quasi‐)solid‐state electrolytes, are also described. Finally, we identify the unsolved problems in current alkali metal–CO2batteries and propose potential topics for future research.
Structurally Diverse Diterpenoids from the Sanya Bay Nudibranch Hexabranchus sanguineus and Its Sponge‐Prey Chelonaplysilla sp.
Authors: Shen Shou‐Mao , Li Song‐Wei , Su Ming‐Zhi , Yao Li‐Gong , Appendino Giovanni , Guo Yue‐Wei 
Published: January 2023

AbstractInvestigation of the South China Sea nudibranch Hexabranchus sanguineus from Sanya Bay afforded, in addition to three known compounds, nine new diterpenoids of the 5,19‐cycloclerodane‐ (sanyanolides A–D), clerodane‐ (sanyanolide E) and subersin‐ (sanyanolides F–I) type. Remarkably, six diterpenoids aforementioned from H. sanguineus were also isolated from the sponge Chelonaplysilla sp. from the same water region, suggesting a trophic relationship between H. sanguineus and Chelonaplysilla sp. The structure and absolute configuration of new compounds were established by a combination of spectroscopic data, X‐ray diffraction analysis and/or time‐dependent density functional theory/electronic circular dichroism calculations. A plausible biogenetic relationship between these diterpenoids, along with the chemo‐ecological implications of their co‐occurrence in the two organisms investigated, was proposed and discussed. In in vitro bioassays, echinoclerodane A exhibited a potent inhibitory effect (IC50=2.81 μM) on LPS‐induced inflammatory response in RAW 264.7 macrophage cells. In addition, echinoclerodane A and oculatolide showed considerable antibacterial activities with MIC values ranging from 1.0 to 8.0 μg/mL.
Iridium‐Catalyzed 1,3‐Rearrangement of Allylic Alcohols
Authors: Li Fei , Luo Yicong , Zhu Xuejie , Ye Yong , Yuan Qianjia , Zhang Wanbin 
Published: January 2023

AbstractThe allylic alcohol structural motif is prevalent in many important molecules and valuable building blocks. The rearrangement reaction is one of the most important transformations, however there are only a few reports for the 1,3‐rearrangement of allylic alcohols. Herein, a 1,3‐rearrangement of allylic alcohols catalyzed by an Ir(III) dihydride complex is described. This reaction could provide the corresponding less accessible allylic alcohols regio‐ and stereoselectively from readily available E/Z mixtures of the substrates. Furthermore, a tandem alkene isomerization followed by 1,3‐rearrangement of homoallylic alcohols was also realized. In addition, this rearrangement reaction could be used to synthesize the natural product Navenone B. Mechanistic investigation indicated that the reaction pathway involved a π‐allyl‐Ir(V) intermediate and that the dihydride in the iridium catalyst acts as a hydrogen switch to modulate the valence of the iridium center.