bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring disease interrelationships in older inpatients: a single-centre, retrospective study
Authors: Ma Yiru , An Kang , Zhang Keni , Deng Han , Deng Rui , Su Qiaoli 
Published: June 2023

BackgroundComorbidity is a common phenomenon in the older population; it causes a heavy burden on societies and individuals. However, the relevant evidence, especially in the southwestern region of China, is insufficient.ObjectivesWe aimed to examine current comorbidity characteristics as well as correlations among diseases in individuals aged &gt;60 years.DesignRetrospective study.MethodsWe included records of 2,995 inpatients treated at the Gerontological Department of Sichuan Geriatric Hospital from January 2018 to February 2022. The patients were divided into groups according to sex and age. Diseases were categorised based on the International Classification of Diseases and their Chinese names. We calculated the age-adjusted Charlson Comorbidity Index (ACCI), categorised diseases using the China Health and Retirement Longitudinal Study questionnaire, and visualised comorbidity using web graphs and the Apriori algorithm.ResultsThe ACCI was generally high, and it increased with age. There were significant differences in the frequency of all diseases across age groups, especially in individuals aged ≥90 years. The most common comorbid diseases were liver diseases, stomach or other digestive diseases, and hypertension. Strong correlations between the most common digestive diseases and hypertension were observed.ConclusionOur findings provide insights into the current situation regarding comorbidity and the correlations among diseases in the older population. We expect our findings to inform future research directions as well as policies regarding general clinical practice and public health, especially for medical consortiums.
Metabolic risk factors attributed burden in Iran at national and subnational levels, 1990 to 2019
Authors: Moradi Soroush , Parsaei Amirhossein , Saeedi Moghaddam Sahar , Aryannejad Armin , Azadnajafabad Sina , Rezaei Negar , Mashinchi Baharnaz , Esfahani Zahra , Shobeiri Parnian , Rezaei Nazila ,   GBD 2019 Iran MRF Collaborators, Naghavi Mohsen , Larijani Bagher , Farzadfar Farshad 
Published: June 2023

IntroductionMetabolic risk factors (MRFs) predispose populations to a variety of chronic diseases with a huge burden globally. With the increasing burden of these risk factors in Iran, in this study, we aimed to report the estimated burden attributed to MRFs at national and subnational scales in Iran, from 1990 to 2019.MethodsBased on the comparative risk assessment method of the Global Burden of Disease (GBD) Study 2019, data of deaths and disability-adjusted life years (DALYs) attributable to four top MRFs in Iran including high systolic blood pressure (SBP), high fasting plasma glucose (FPG), high body mass index (BMI), and high low-density lipoprotein (LDL) for the 1990–2019 period, were extracted. The socio-demographic index (SDI) was used to report the data based on the corresponding socio-economic stratifications. The results were reported in national and subnational 31 provinces of Iran to discover disparities regarding the attributable burden to MRFs. Furthermore, we reported the causes of diseases to which the attributable burden to MRFs was related.ResultsOverall, the age-standardized high LDL, high SBP, high BMI, and high FPG-attributed death rate changed by −45.1, −35.6, +2.8, and +19.9% from 1990 to 2019, respectively. High SBP was the leading risk factor regarding attributed age-standardized death rates reaching 157.8 (95% uncertainty interval: 135.3–179.1) and DALY rates reaching 2973.4 (2652.2–3280.2) per 100,000 person-years, in 2019. All rates increased with aging, and men had higher rates except for the +70 years age group. At the subnational level, provinces in the middle SDI quintile had the highest death and DALY rates regarding all four MRFs. Total deaths, DALYs, YLLs and YLDs number by the causes of diseases linked to MRFs increased over the study period. Cardiovascular diseases, diabetes mellitus, and kidney diseases were the main causes of burden of disease attributable to MRFs.ConclusionHerein, we found divergent patterns regarding the burden of MRFs as well as disparities in different regions, sex, and age groups for each risk factor and related causes. This could provide policymakers with a clearer vision toward more appropriate decision-making and resource allocation to prevent the burden of MRFs in Iran.
Childhood abuse and association with adult depressive symptoms among people with cardiovascular disease
Authors: Yin Ruoyun , Yang Yuan , Tang Lei , Chang Yujiao , Zhang Fan 
Published: June 2023

BackgroundTo study the association between the total/different types of childhood abuse and adult depressive symptoms in people with cardiovascular disease (CVD).MethodsThe subjects were people with CVD who continuously participated in the China Health and Retirement Longitudinal Study (CHARLS) life history survey and the 2018 wave of the CHARLS national baseline Survey. Multi-level logistic regression models were used to analyze the relationship between emotional neglect, physical neglect, physical abuse and adult depressive symptoms.ResultsA total of 4,823 respondents were included in this study. The incidence of childhood abuse (existed emotional neglect, physical neglect or physical abuse) was 43.58% among people over 45 years old with CVD, which was higher than that of the general population (36.62%, p &lt; 0.05). Adjusted model showed that overall childhood abuse was associated with adult depressive symptoms (OR = 1.230, 95%CI:1.094–1.383). Among different types of childhood abuse, only physical abuse was associated with depressive symptoms in adulthood (OR = 1.345, 95%CI:1.184–1.528).ConclusionCompared with that of the general population, the incidence of childhood abuse in CVD population is higher. Physical abuse in childhood increased the risk of depressive symptoms in adulthood. It suggested that the occurrence of depressive symptoms was the result of related factors in the whole life course. In order to prevent the depressive symptoms, childhood abuse also needs to be considered. It is very important to identify and prevent the continuation of childhood abuse in time.
A case-control study of tackle based head impact event (HIE) risk factors from the first three seasons of the National Rugby League Women's competition
Authors: McLeod Shreya , Tucker Ross , Edwards Suzi , Jones Ben , Page Georgia , Spiegelhalter Mily , West Stephen W. , Iverson Grant L. , Gardner Andrew J. 
Published: June 2023

ObjectiveThe tackle is the most injurious event in rugby league and carries the greatest risk of concussion. This study aims to replicate previous research conducted in professional men's rugby league by examining the association between selected tackle characteristics and head impact events (HIEs) in women's professional rugby league.MethodsWe reviewed and coded 83 tackles resulting in an HIE and every tackle (6,318 tackles) that did not result in an HIE for three seasons (2018–2020) of the National Rugby League Women's (NRLW) competition. Tackle height, body position of the tackler and ball carrier, as well as the location of head contact with the other player's body were evaluated. Propensity of each situation that caused an HIE was calculated as HIEs per 1,000 tackles.ResultsThe propensity for tacklers to sustain an HIE was 6.60 per 1,000 tackles (95% CI: 4.87–8.92), similar to that of the ball carrier (6.13 per 1,000 tackles, 95% CI: 4.48–8.38). The greatest risk of an HIE to either the tackler or ball carrier occurred when head proximity was above the sternum (21.66 per 1,000 tackles, 95% CI: 16.55–28.35). HIEs were most common following impacts between two heads (287.23 HIEs per 1,000 tackles, 95% CI: 196.98–418.84). The lowest propensity for both tackler (2.65 per 1,000 tackles, 95% CI: 0.85–8.20) and ball carrier HIEs (1.77 per 1,000 tackles, 95% CI: 0.44–7.06) occurred when the head was in proximity to the opponent's shoulder and arm. No body position (upright, bent or unbalanced/off feet) was associated with an increased propensity of HIE to either tackler or ball carrier.ConclusionsIn the NRLW competition, tacklers and ball carriers have a similar risk of sustaining an HIE during a tackle, differing from men's NRL players, where tacklers have a higher risk of HIEs. Further studies involving larger samples need to validate these findings. However, our results indicate that injury prevention initiatives in women's rugby league should focus on how the ball carrier engages in contact during the tackle as well as how the tackler executes the tackle.
Comparative study of pancreatic vessels and mesopancreas of rhesus monkeys and humans
Authors: Ye Fan , Xiong Hang , Su Hongyu , Huang Ziheng , Luo Wenxin , Yuan Dongmei , Yi Tao , Zhou Hongying 
Published: June 2023

IntroductionWith the introduction of the concept of mesopancreas defining the perineural structures that includes neurovascular bundle and lymph nodes extending from the posterior surface of the pancreatic head to behind the mesenteric vessels,Total Mesopancreas Excision (TMpE) based on this theory has facilitated the development of pancreatic cancer surgery in clinical practice in recent years. However, the existence of so called mesopancreas in the human body is still in debate and the comparative study of mesopancreas of rhesus monkey and human have not been well investigated.PurposeThe aim of our study is to compare the pancreatic vessels and fascia of human and rhesus monkeys in anatomical and embryological perspectives and to support the utilization of rhesus monkey as animal model.MethodsIn this study, 20 rhesus monkey cadavers were dissected and their mesopancreas location, relationships and arterial distribution were analyzed. We compared the location and developmental patterns of mesopancreas in macaques and humans.ResultsThe results showed that the distribution of pancreatic arteries in rhesus monkeys was the same as that in humans, which is consistent with phylogenetic similarities. However, the morphological features of the mesopancreas and greater omentum is anatomically different from that of humans, including (1) the greater omentum is not connected to the transverse colon in monkeys. (2) The presence of the dorsal mesopancreas of the rhesus monkey suggests that it be an intraperitoneal organ. Comparative anatomical studies of mesopancreas and arteries in macaques and humans showed characteristic patterns of mesopancreas and similarities in pancreatic artery development in nonhuman primates, consistent with phylogenetic differentiation.
Mitogenomic Research of Silverleaf Sunflower (Helianthus argophyllus) and Its Interspecific Hybrids
Authors: Makarenko Maksim S. , Azarin Kirill V. , Gavrilova Vera A. 
Published: June 2023

Interspecific hybridization is widespread for sunflowers, both in wild populations and commercial breeding. One of the most common species that can efficiently cross with Helianthus annuus is the Silverleaf sunflower—Helianthus argophyllus. The current study carried out structural and functional organization analyses of mitochondrial DNA in H. argophyllus and the interspecific hybrid, H. annuus (VIR114A line) × H. argophyllus. The complete mitogenome of H. argophyllus counts 300,843 bp, has a similar organization to the mitogenome of cultivated sunflower, and holds SNPs typical for wild sunflowers. RNA editing analysis predicted 484 sites in H. argophyllus mitochondrial CDS. The mitochondrial genome of the H. annuus × H. argophyllus hybrid is identical to the maternal line (VIR114A). We expected that significant rearrangements in the mitochondrial DNA of the hybrid would occur, due to the frequent recombination. However, the hybrid mitogenome lacks rearrangements, presumably due to the preservation of nuclear–cytoplasmic interaction paths.
Plant Extracts as a Source of Natural Products with Potential Antimalarial Effects: An Update from 2018 to 2022
Authors: Ribeiro Giovane de Jesus Gomes , Rei Yan Sun Liu , Palmisano Giuseppe , Wrenger Carsten 
Published: June 2023

Malaria kills more than 500,000 people yearly, mainly affecting Africa and Southeast Asia. The disease is caused by the protozoan parasite from the genus Plasmodium, with Plasmodium vivax and Plasmodium falciparum being the main species that cause the disease in humans. Although substantial progress has been observed in malaria research in the last years, the threat of the spread of Plasmodium parasites persists. Artemisinin-resistant strains of this parasite have been reported mainly in Southeast Asia, highlighting the urgent need to develop more effective and safe antimalarial drugs. In this context, natural sources, mainly from flora, remain underexplored antimalarial spaces. The present mini-review explores this space focusing on plant extracts and some of their isolated natural products with at least in vitro antiplasmodial effects reported in the literature comprising the last five years (2018–2022).
Investigation of the Structural Dependence of the Cyclical Thermal Aging of Low-Voltage PVC-Insulated Cables
Authors: Bal Semih , Tamus Zoltán Ádám 
Published: June 2023

The increasing penetration of distributed generation sources in low-voltage distribution grids, electric vehicles, and new appliances from the consumer side can generate short repetitive overloads on the low-voltage cable network. This work investigates the change in the dielectric properties of low-voltage cable insulation caused by short-term overloads, examining how the cable structure affects the dielectric characteristics of the cable specimens in the case of cyclic short-term thermal aging. PVC-insulated low-voltage cable samples were exposed to an accelerated aging test in a temperature-controlled oven after changing their structures by removing different layers. Three aging cycles, each of six hours, were applied to the samples. After each cycle, the tan δ and capacitance were measured by an Omicron DIRANA Dielectric Response Analyzer in the laboratory at room temperature 24 ± 0.5 °C. Furthermore, the polarization and depolarization currents were also studied. The results show that changing the cable structure impacts the dielectric parameters; in particular, the effect of the belting layer is significant. From the point of view of aging, the PVC belting layer protects the diffusion of the plasticizers of the inner structure. The findings of the study show that an asymmetric aging phenomenon can be observed in different polymeric components of the cables, even though the cables were aged in an air-circulated oven ensuring a homogeneous temperature distribution in the samples.
Insights into the Regulation of GFR by the Keap1-Nrf2 Pathway
Authors: Kidokoro Kengo , Kadoya Hiroyuki , Cherney David Z. I. , Kondo Megumi , Wada Yoshihisa , Umeno Reina , Kishi Seiji , Nagasu Hajime , Nagai Kojiro , Suzuki Takafumi , Sasaki Tamaki , Yamamoto Masayuki , Kanwar Yashpal S. , Kashihara Naoki 
Published: June 2023

Key Points

Kelch-like erythroid cell-derived protein with CNC homology (ECH)-associated protein 1-NF (erythroid-derived 2)–like 2 pathway increases GFR without an appreciable increase in intraglomerular pressure.Kelch-like ECH-associated protein 1-NF (erythroid-derived 2)–like 2 pathway regulates GFR through changes in filtration area by modulating calcium dynamics and contractility in glomerular cells.

Background
Literature data suggest that the activation of the Kelch-like ECH-associated protein 1 (Keap1)-NF (erythroid-derived 2)–like 2 (Nrf2) pathway increases GFR in patients with type 2 diabetes and CKD. However, the mechanisms whereby the Keap1-Nrf2 pathway regulates GFR are unknown.

Methods
Various renal physiological parameters were assessed in C57BL/6 mice (wild-type), Nrf2-deficient mice, and Nrf2-activated Keap1-knockdown mice. In addition, these parameters were assessed after the administration of receptor targeting agent (RTA) dh404 (CDDO‐dhTFEA), an Nrf2 activator.

Results
Pharmacologic and genetic Keap1-Nrf2 activation increased renal blood flow (P < 0.05), glomerular volume (P < 0.05), and GFR (P < 0.05) but did not alter the afferent-to-efferent arteriolar diameter ratio or glomerular permeability. Calcium influx into the podocytes through transient receptor potential canonical (TRPC) channels in response to H2O2 was suppressed by Keap1-Nrf2 activation and TRPCs inhibition. Treatment with a TRPC6 and TRPC5 inhibitors increased single-nephron GFR in wild-type mice.

Conclusions
In conclusion, the Keap1-Nrf2 pathway regulates GFR through changes in ultrafiltration by modulating redox-sensitive intracellular calcium signaling and cellular contractility, mediated through TRPC activity, in glomerular cells, particularly the podocytes.
Perilaku asertif dengan harga diri mahasiswa dalam melaksanakan pembelajaran daring
Authors: Hidayatullah Rizki Maulana , Alifah Nur 
Published: June 2023

Self esteem is one factor that can inflate behavior assertive someone, with evaluation self describing how his precious and also understood he able to encourages individual competence for easy expressing himself into the area. This study was conducted in form to track the relationship between the price of behaviors assertive students during a pandemic. Used for the study sample was taken using all the people in every class with a total some 200 people. Analysis techniques the data used was pearson correlation. The result of the research is that there a positive relationship between the behaviors assertive students with the significance and value of 0.000 coefficient 0.673 obtained.
Pengaruh Mutu Pelayanan Kesehatan Terhadap Kepuasan Pasien Rawat Inap Masa Pandemi Covid-19 Di Rsud Polewali
Authors: Rahmatilla Rahmatilla , Mukharrim Muh. Said , Abidin Urwatil Wusqa 
Published: June 2023

Tujuan pada penelitian ini ialah agar memahami pengaruh mutu pelayanan kesehatan terhadap kepuasan pasien rawat inap masa pandemi Covid-19 di Rumah Sakit Umum Daerah (RSUD) Kabupaten Polewali Mandar Tahun 2021 berdasarkan 5 dimensi mutu pelayanan yakni bukti fisik (tangibles), keandalan (reliability), cepat tanggap (responsiveness), jaminan (assurance), kepedulian (empathy). Jenis penelitian ini adalah kuantitatif desain penelitian crossectional pendekatan survei analitik. Populasi dalam penelitian ini adalah pasien Rumah Sakit Umum Daerah (RSUD) Kabupaten Polewali Mandar yang melakukan kunjungan rawat inap ruangan Asoka pada bulan Oktober Tahun 2020 – Bulan Maret Tahun 2021 sebanyak 161 pasien dengan pengambilan sampel menggunakan teknik Accidental Sampling.Hasil uji statistik menggunakan uji Chi Square dan uji fisher exact test diperoleh nilai ρ = 0,000 < α = 0,05 maka Ho ditolak dan H1 diterima. Artinya, ada pengaruh antara mutu pelayanan kesehatan terhadap kepuasan pasien rawat inap masa pandemi Covid-19 di Rumah Sakit Umum Daerah (RSUD) Kabupaten Polewali Mandar.
Sistem Informasi Distribusi Penjualan Ikan di Tempat Pelelangan Ikan Polewali
Authors: Ramadhan Ramadhan , Qashlim Akhmad , Tamin Rosmawati 
Published: June 2023

Setiap wilayah di Indonesia memiliki banyak sumber daya alam termasuk produksi ikan, salah satunya adalah ikan laut. Dari sumber daya alam tersebut, banyak nelayan yang menjadikannya sebagai profesi, yaitu menangkap ikan. Ikan hasil tangkapan akan dijual di TPI (Tempat Pelelangan Ikan), kemudian akan ditimbang dan diberi imbalan sesuai dengan standar harga ikan yang berlaku saat itu. . Di sirkuit distribusi, produsen sering menggunakan perantara, distributor, yang merupakan operasi otonom antara produsen dan konsumen akhir. Hal ini dikarenakan ikan menempuh banyak jalur sebelum sampai ke konsumen akhir, semakin panjang jalurnya maka harga ikan akan semakin mempengaruhi konsumen. Penelitian ini akan merancang sistem distribusi penjualan ikan di Tpi Polewali berdasarkan tingkatan yang diamati pada beberapa event sebelumnya. Data penelitian disajikan secara web untuk memudahkan melihat persebaran perdagangan ikan di Tpi Polewali. Penelitian ini bertujuan untuk membangun sebuah aplikasi sistem informasi distribusi penjualan ikan di Tpi Polewali. Penelitian dilakukan di Dinas Kelautan dan Perikanan. Hasil penelitian ini berupa scorecard evaluasi tingkat kualitas sistem distribusi ikan di TPI Polewali yang disajikan dalam bentuk web interface.
HUBUNGAN ANTARA PERILAKU MEROKOK SISWA DENGAN PRESTASI BELAJAR SISWA SMA NEGERI 2 BAMBANG KECAMATAN BAMBANG KABUPATEN MAMASA
Authors: Yispan Yispan , Asri Asri , Asis Sulihin 
Published: June 2023

Abstract Learning achievement can be influenced by intelligence (cognitive), memory and concentration power. Concentration, cognitive and memory power can be influenced by students' smoking behavior which can cause a decrease in learning achievement. This study aims to determine the relationship between student smoking behavior and learning achievement in SMA 2 Bambang, Mamasa Regency.The purpose of this study was to determine the relationship between smoking behavior and student achievement at SMA 2 Bambang. The type of research used in this research is quantitative research with analytical survey method with cross sectional design. After that, analysis of the dynamics of the correlation between the relationship between smoking behavior and student achievement was carried out. The population in this study was as many as 50 male students who smoked and the sampling in this study was a total sampling of 50 people.The results showed that there was a relationship between the variable smoking behavior of students and student achievement where the p-value (0.005) < a (0.05). This shows that Ho is rejected and H1 is accepted and shows that there is a significant relationship between smoking behavior and student achievement in SMA NEGERI 2 Bambang Bambang Subdistrict, Mamasa Regency.The conclusion of this research is that there is a relationship between smoking behavior and learning achievement. Keywords: smoking behavior, student achievement Abstrak Prestasi belajar dapat dipengaruhi intelegensi (kognitif), daya ingat dan daya konsentrasi. Daya konsentrasi, kognitif dan daya ingat dapat dipengaruhi oleh perilaku merokok siswa yang dapat menyebabkan turunnya prestasi belajar. Penelitian ini bertujuan untuk mengetahui hubungan perilaku merokok siswa dengan prestasi belajar SMA 2 bambang kabupaten mamasa.Tujuan dilakukan penelitian ini adalah untuk Untuk mengetahui hubungan perilaku merokok dengan prestasi belajar siswa SMA 2 Bambang. Jenis penelitian yang di gunakan dalam penelitian ini adalah penelitian kuantitatif dengan metode survey analitik dengan desain cross sectional. Setelah itu dilakukan analisis dinamika korelasi antara hubungan perilaku merokok dengan prestasi belajar siswa. Populasi dalam penelitian ini adalah selurus siswa laki-laki yang merokok sebanyak 50 orang dan penarikan sampel dalam penelitian ini adalah total sampling sebanyak 50 orang.Hasil penelitian menunjukkan ada hubungan antara pariabel perilaku merokok siswa dengan prestasi belajar siswa dimana nilai p-value (0,005) < a (0,05). Hal ini menunjukkan bahwa Ho ditolak dan H1 titerima dan menunjukan ada hubunhan yang sgmifikan antara perilaku merokok dengan prestasi belajar siswa SMA NEGERI 2 Bambang Kecamatan Bambang Kabupaten MamasaKesimpulan penelitian diperoleh adanya hubungan antara perilaku merokok dengan prestasi belajar. Kata kunci: perilaku merokok, prestasi belajar siswa