bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variantes genéticas recurrentes y priorización de variantes de significado clínico desconocido asociadas al síndrome de cáncer de mama y ovario hereditario en familias de la Región de Murcia
Authors: Rosado-Jiménez Laura , Mestre-Terkemani Younes , García-Aliaga Ángeles , Marín-Vera Miguel , Macías-Cerrolaza José Antonio , Sarabia-Meseguer María Desamparados , García-Hernández María Rosario , Zafra-Poves Marta , Sánchez-Henarejos Pilar , Ayala de la Peña Francisco , Alonso-Romero José Luis , Noguera-Velasco José Antonio , Ruiz-Espejo Francisco 
Published: July 2023

Resumen

Objetivos
El síndrome de cáncer de mama y ovario hereditario (SCMOH) presenta un patrón de herencia autosómica dominante en genes de susceptibilidad al cáncer y su riesgo está principalmente vinculado a mutaciones germinales en BRCA1 y BRCA2. Sin embargo, la implementación de paneles genéticos mediante secuenciación masiva en la práctica asistencial, ha ampliado el espectro mutacional de este síndrome hereditario y el número de variantes de significado clínico desconocido (VUS) detectadas en los estudios genéticos.

Métodos
El estudio de prevalencia del SCMOH realizado en 2928 familias de la Región de Murcia ha permitido identificar las variantes patogénicas recurrentes y mutaciones fundadoras, principalmente asociadas a genes BRCA1 y BRCA2. En el estudio de VUS destaca la aplicación de un algoritmo de priorización diseñado por nuestro grupo de trabajo.

Resultados
Las variantes c.68_69del, c.212+1G>A, y c.5123C>A fueron detectadas en un 30 % de los portadores de BRCA1 mientras que la deleción del exón 2 junto con c.3264dupT, c.3455T>G y c.9117G>A se han encontrado en un 30 % de los portadores de BRCA2. Un total de 16 VUS (15 %) fueron priorizadas.

Conclusiones
La correlación genotipo-fenotipo resultó compatible con lo reportado previamente en la literatura científica. Además, se ha constatado el efecto fundador de c.1918C>T (BRCA1) y c.8251_8254del (ATM) en población murciana y la deleción del exon2 (BRCA2) como mutación fundadora española. La implementación del algoritmo ha permitido priorizar aquellas VUS susceptibles de patogenicidad en las que sería recomendable realizar estudios complementarios para así, poder determinar su efecto clínico y su posible implicación en el SCMOH.
A STRATEGIC DIRECTIONS OF SUSTAINABLE DEVELOPMENT FOR FISHERIES SECTOR IN VIETNAM
Authors: Hoi Nguyen Chu 
Published: July 2023

Viet Nam has an advantages and potentials for fisheries economy development and fisheries activities links closely to local community life. In the past innovated 20 years, the sector has reached to important achievements: It has been changed into a key production sector with high economic contribution; multi-class economic component with oriented-market mechanism and contributed to poverty reduction in rural areas … However, the sector is facing with a lot of challenges in the way to sustainable development (SO): Aquatic environments have been polluted and degraded more and more, increased diseases in aquaculture, loss of aquatic biodiversity, over-exploitation in some water bodies (especially in near-shore), destroyed relevant ecosystems/habitats, livelihoods of the local people still not improved, fisheries management is limited in term of policy and human qualification, the issues “fishers, fisheries and fishing ground” are still not addressed, economic effects and competition of the fishery products are not strong and un-stained. Therefore, development of a Strategic Direcrions of Sustainable Development for Fisheries Sector in Vietnam (Draft of Agenda-21 for Fisheries Sector) has been drafted under guiding by Ministry of Fisheries. The Agenda includes main aspects as following: conceptions of SO and sustainable fisheries in context of Vietnam; main achievements of the fisheries sector in the past 20 years and challenges/obstacles; Vietnam future of fisheries and global fisheries outlook; SD goals for fisheries, guiding principles, strategic directions and priorities: and integration of SD of fisheries in annually/5 years investment projects and planning. The paper only presents about main aspects of the Agenda 21 for Fisheries Sector.
Kualitas Proses dan Hasil Pembelajaran Melalui NHT Berorientasi Inquiri Terbimbing pada Materi Perbandingan dan Skala di SD Se- Gugus Ahmad Yani Kecamatan Gringsing, Batang
Authors: Juharti Juharti , Saputro Bagus Ardi , Nugroho Aryo Andri 
Published: July 2023

Penelitian ini dilatarbelakangi oleh rendahnya hasil belajar peserta didik , pembelajaran masih pasif, peserta didik merasa takut dan sulit mengungkapkan pendapat dan ketertarikan peserta didik pada pelajaran Matematika masih rendah yang salah satu penyebabnya adalah penggunaan dan pemilihan model pembelajaran yang kurang tepat. Peneliti menggunakan model pembelajaran NHT (Number Head Together) berorintasi inquiri terbimbing. Penelitian ini bertujuan untuk mengetahui kualitas proses dan hasil pembelajaran melalui NHT Berorientasi Inquiri Terbimbing pada Materi Perbandingan dan Skala di SD Se-Gugus Ahmad Yani Kecamatan Gringsing, Batang. Pemilihan populasi dan sampel penelitian dilakukan dengan teknik purposive sampling yaitu peserta didik kelas V di SD Negeri Sawangan 01. Metode penelitian yang digunakan adalah pre-experimental design tipe one group pretest-posttest (tes awal-tes akhir kelompok tunggal) pengambilan sampel penelitian ini menggunakan 1 kelompok belajar yang berjumlah 15 peserta didik. Instrument dalam penelitian ini menggunakan tes sebanyak dua kali, yaitu sebelum diberi perlakuan disebut pretest dan sesudah perlakuan disebut posttest . Variabel pada penelitian ini terdiri dari variabel bebas model NHT (Numbered Heads Together) berorientasi inquiri terbimbing dan variabel terikat adalah kualitas proses dan hasil pembelajaran. Metode analisis data dilakukan dengan menerapkan uji one Sampel t-test untuk menguji hipotesis. One Sampel t-test diperoleh sig. (2-tailed) sebesar 0,000 < 0,05, maka artinya Ho ditolak dan Ha diterima atau ada perbedaan rata-rata signifikasi pada model pembelajaran yang digunakan.
Evaluation of Maintenance Management in Iraqi Governmental Buildings
Authors: Doos Qasim Mohammed , Al-Saadwi Kadhim Raheem , Ibraheem Haider Khaleel 
Published: July 2023

Impact of buildings in Iraq and other countries on the environment is obvious; this problem began to take scientific and humanitarian dimensions in order to reduce and eliminate this problem. This impact can be seen through the energy, water and raw materials consumed for the establishment, operation and maintenance of these buildings, as well as the emissions of hazardous gases and generations of solid wastes.
This work was conducted to assess the current maintenance managerial practice for the governmental buildings to stand on the main obstacle and extrapolation of measures by means of interviews with experts to determine the effective factors and closed questionnaire to state the features and the need for new building maintenance management system which may assist for modeling new building maintenance management system which may help to reduce the deterioration levels of governmental buildings and the emission of hazardous gases and solid waste with cost efficient approach.
ANALISIS PENGARUH PROGRAM MAGANG DAN EFIKASI DIRITERHADAP KOMPETENSI PEDAGOGIK
Authors: Kristina Fera , Sitorus Destri Sambara , Sadjiarto Arief 
Published: July 2023

ABSTRAKKompetensi pedagogik diperlukan oleh calon pendidik sebagai dasar dalam menjalankan proses pembelajaran yang bermutu. Tujuan penelitian ini adalah untuk mengetahui kompetensi pedagogik mahasiswa FKIP UKSW Salatiga melalui program magang dan efikasi diri. Jenis penelitian ini adalah kuantitatif. Populasi dalam penelitian ini adalah 292 mahasiswa FKIP UKSW dengan penentuan sampel sebanyak 88 mahasiswa. Teknik pengumpulan data yang digunakan dalam penelitian ini menggunakan kuesioner melalui google form. Hasil penelitian ini secara parsial nilai signifikansi variabel program magang (X1) sebesar 0,013 < 0,05 dan nilai signifikansi variabel (X2) sebesar 0,000 < 0,05. Secara simultan nilai signifikansi variabel X1 dan X2 adalah 0,000 < 0,05. Dapat disimpulkan bahwa baik secara parsial maupum simultan program magang dan efikasi diri berpengaruh positif dan signifikan terhadap kompetensi pedagogik di kalangan mahasiswa FKIP UKSW Salatiga. Saran yang penulis berikan adalah agar mahahsiswa dapat mempraktikkan dan menghayati proses belajar mengajar selama pelaksanaan program magang serta menambah rasa percaya diri sehingga terbangun kompetensi pedagogic yang baik dalam diri setiap mahasiswa. kata Kunci: Kompetensi pedagogik, program magang, efikasi diriABSTRACTPedagogic competence is needed by prospective educators as a basis for darrying out a quality learning process. The purpose of this study was to determine the pedagogic competence among SWCU Salatiga FKIP students through internship and self-efficacy programs. This type of research is quantitative. The population in this study were 292 SWCU FKIP students with a sample determination of 88 students. The data collection technique ised in this research is to use questionnaire given via google form.. The results of this study are partially the significant value of the internship program variable (X1) is 0.013 <0.05 and the value of the self-efficacy variable (X2) is 0.000 <0.05. Simultaneously the significant value of the variables X1 and X2 is 0.000 < 0.05. It can be concluded that either partially or simultaneously the internship program and self-efficacy have a positive and significant impact on pedagogic competence among SWCU FKIP Salatiga students. The advice that the author gives is so that students can practice and live up to the teaching and learning process during the implementation of the internship program and increase self-confidence so that good pedagogic competence is built in each student.Keywords; Pedagogic competence, internship program, self efficacy
Klasifikasi Sentimen Masyarakat di Twitter terhadap Ganjar Pranowo dengan Metode K-Nearest Neighbor
Authors: Sayed Sayed Omas Tutus Arifta , Yusra  , Muhammad Fikry  
Published: July 2023

Ada banyak jenis media sosial untuk mengumpulkan informasi, berbagi informasi dan berbagi berita, salah satunya adalah Twitter. Dalam penelitian ini, klasifikasi berbasis sentimen dilakukan dalam dua kategori, yaitu positif dan negatif, dengan mengaplikasikan metode K-Nearest Neighbor pada sosok gubernur Jawa Tengah yaitu bapak Ganjar Pranowo. K-Nearest Neighbor adalah metode pengklasifikasian objek berdasarkan data training yang menggunakan jarak atau kemiripan terkecil dari objek tersebut. Pada tahap pembelajaran, algoritma ini hanya menyimpan vektor karakteristik dan mengklasifikasikan data pembelajaran. Selama tahap klasifikasi, fitur-fitur yang sama dihitung untuk data uji, yang mana kelasnya tidak diketahui. Jarak dari vektor baru ini ke vektor data pelatihan dihitung dan K berikutnya diambil. Penelitian ini bertujuan untuk mendapatkan nilai akurasi menggunakan 4.000 data dengan sentimen negatif dan positif yang masing-masing berjumlah 2.000. Setelah data tweet berhasil diambil dari Twitter, data tersebut masih berbentuk mentah dan memerlukan tahap preprocessing untuk menghasilkan data yang bersih dan siap untuk diproses pada tahap selanjutnya. Perhitungan nilai akurasi dengan mengklasifikan sentimen masyarakat di Twitter terhadap Ganjar Pranowo menggunakan metode K-Nearest Neighbor dalam menguji akurasi menghasilkan nilai akurasi yang cukup baik yaitu 81% precision 81 % recall 81%.
Variabilité Climatique Et Vulnérabilité Des Systèmes De Productions Agropastorales Dans Le Bassin Versant De La Rivière Agbado Au Centre Du Bénin
Authors: R. Ignace VISSOH , Ringo F Avahounlin , Gilbert Danhossou , Josaphat Avahounlin , Expédit W. Vissin 
Published: July 2023

L’objectif de cette étude est d’évaluer l’état de vulnérabilité des systèmes de productions agropastorales face à la variabilité climatique dans le bassin de la rivière Agbado au centre du Bénin. Ainsi à partir des chroniques de données hydroclimatiques ; des statistiques démographiques et des données planimétriques, des méthodes statistiques d’analyses climatiques ont été appliquées pour caractériser l’impact de la variabilité climatique sur les productions agricoles dans le secteur d’étude. L’analyse de la variabilité interannuelle des pluies montre une alternance des années humides et sèches suivi d’une recrudescence de crues. Puis en se basant sur les lois de probabilité statistique de l’analyse fréquentielle la fréquence des extrêmes pluviométriques et hydrologiques observés ont été déterminer. Ainsi les événements hydrologiques qui ont une probabilité de 0,01 de subvenir sont estimés à 731 m3/s. De plus il est montré que l’agriculture et l’élevage sont les activités les plus exposés avec des taux d’exposition de 90 % et 80 %.
APPRAISAL OF URBANIZATION AND ITS IMPACTS ON THE ALBEDO AND CLIMATE CHANGE OF THE PUNJAB-PAKISTAN: A SPATIO-TEMPORAL ANALYSIS
Authors: D. Amjad  , S.A.Shirazi  , F.Sarwar  , R.W.Aslam  , S.Kousar  
Published: July 2023

The research is aimed at evaluating the process of urbanization and it’s spatio-temporal impacts on albedo and the changing climate of the Punjab. Climate change in urban areas has
become a public focal point, as urban development in our present-day environment is one of the mostcritical aspects of human activities. The shift in the reflective properties of the surface is one of theparticular climatic consequences of urbanization which most researchers have overlooked (Albedo).Changes in urbanized land surface properties resulted in a global, regional, and local changes inbiochemical cycles and environment. This analysis aims to identify the urban land use of the 1990-2018 study area (decadal) and evaluate Albedo and Climatic Variables' trends over the selected region.This study will provide a complete code of classification in Google Earth Engine for researchers. InGoogle Earth Engine, the classification technique was utilized to detect urban areas and barren landcover types by applying coding over four images of 1990, 2000, 2010, and 2018 of Punjab Province.The Albedo maps were created in the same way for the years 2000 and 2018. Climatic maps werecreated from 1990 to 2018 by applying the Inverse Distance Weighted method in a GIS system. Therehas been an apparent increase in the urban area of Punjab Province from 1990 to 2018. The urban areahas increased from 1183.5342 km2 to 8396.4618 km2 during the study period. Results from climaticmaps showed hotspots in the areas that have undergone urbanization. Overall, the accuracy of theclassification images was 81-88 percent, which was foremost to achieve the objectives of the research.
Assessing the impact of political partnerships on coordinated meta-governance of regional governance
Authors: Higdem Ulla 
Published: July 2023

New partnership-arrangements appear to increase the need to impose democratic controls over devolved processes. The challenges of political anchorage in meta-governance alter when several public meta-governors are accountable for the results. This article focuses on political partnerships’ ability to establish coordinated meta-governance of regional governance between the politically elected bodies, which in this case is the county council and the municipalities. On the basis of an empirical study of a Norwegian case of regional councils, namely, partnerships between the municipalities and the county, I show how the traditional concept of steering and the understanding of meta-governance together may provide a comprehensive way to analyse the capacities of meta-governance amongst public actors. The analysis suggests that the most important factors of the partnership for creating or enhancing coordinated and meta-governance of regional governance are storytelling, formal agreements, and facilitation. Even though politicians are ‘hands on’ in the partnership, the analysis suggests that an insufficient anchorage back to the democratically elected bodies still presents a challenge of coordinated meta-governance to the partnership.
Ethical codes in local government: the problem of gifting -
Authors: Salminen Ari , Pitkänen Lotta , Heiskanen Lauri 
Published: July 2023

The article explores the purpose of ethical codes in Finnish local government and discusses such topics as identification of codes and dilemmas, ethical awareness of gifting, role of codes and need of codes. The data is based on the Councilor Survey. The respondents of the survey are the members of Finnish municipal councils. The Survey is targeted to the 200 biggest municipalities and was distributed to the councilors in November 2012. More than 5000 persons received the questionnaire, which was returned by nearly 1300.
According to the results, the recognition of ethical codes is low among the councilors. The amount of those who operate without the guidance of codes is remarkable. The councilors are aware what is and what is not acceptable in gifting and are convinced that they are capable of self-control when it comes to potential integrity violations.
The attitudes towards the role of codes are contradictory. The councilors want more detailed guidance. They still emphasize that codes should leave room for their own discretion. The need for more regulation by codes is stressed by the councilors. The codes should be targeted for specific issues and the elected members should have their own ethical codes.
Inverse volatility problem for currency options
Authors: Knowles Ian , Tamang Sundar 
Published: July 2023

In transactions associated with future-oriented financial instruments, such as options, a huge amount of data is available buried inside of which is the market's best guess as to what the future holds. We consider here the possibility of extracting future foreign exchange volatility information from foreign exchange option data with the aid of a new computational inverse algorithm using minimization of a convex functional.
See also https://ejde.math.txstate.edu/special/02/k1/abstr.html
Experimental and numerical study on the dry/wet burst failure of reinforced thermoplastic pipes
Authors: Liu Wencheng , Ding Xindong , Wang Shuqing , Xu Mingqiang 
Published: July 2023

AbstractThis paper investigates the burst failure of reinforced thermoplastic pipes (RTPs) via combined experimental and numerical research. Two completely different burst forms appeared during the experiments. The dry burst form occurs with matrix cracks, fiber breakage and crack of liner and coating, which is a common burst morphology. A new burst morphology, which is never reported in open literature, is observed in the experiments. This burst morphology, defined as wet burst form, presents a long dent in the coating and invisible composite damage. In order to simulate the burst failure of RTPs, a numerical model was proposed, in which element removal criteria and the nonlinear stiffness degradation model based on Hashin‐Yeh failure criterion were employed to conduct progressive failure analysis on 3D composites. It was found that the wet burst form has lower burst pressure and causes larger damaged area, which is more dangerous in engineering. For the damage propagation, progressive failure occurs on middle composites and induces the final burst when the dry burst form occurs. As for the wet burst form, water flows into the middle of RTPs, which causes the delamination, matrix crack and bulge of coating. During the process, fibers play few roles in bearing loads.Highlights
The wet burst form of reinforced thermoplastic pipes is firstly observed.
Element removal criteria and nonlinear stiffness degradation model were used to simulate the burst failure.
The numerical model has a good performance on predicting the burst pressure and damage propagation of composites.
The wet burst form has lower burst pressure compared with the dry burst form.
Fiber and matrix tensile failure mode are dominant.
Conformationally constrained cyclic grafted peptidomimetics targeting protein–protein interactions
Authors: Dahal Achyut , Subramanian Vivekanandan , Shrestha Prajesh , Liu Dong , Gauthier Ted , Jois Seetharama 
Published: July 2023

AbstractSunflower trypsin inhibitor‐1 (SFTI‐1) structure is used for designing‐grafted peptides as a possible therapeutic agent. The grafted peptide exhibits multiple conformations in solution due to the presence of proline in the structure of the peptide. To lock the grafted peptide into a major conformation in solution, a dibenzofuran moiety (DBF) was incorporated in the peptide backbone structure, replacing the Pro‐Pro sequence. NMR studies indicated a major conformation of the grafted peptide in solution. Detailed structural studies suggested that SFTI‐DBF adopts a twisted beta‐strand structure in solution. The surface plasmon resonance analysis showed that SFTI‐DBF binds to CD58 protein. A model for the protein‐SFTI‐DBF complex was proposed based on docking studies. These studies suggested that SFTI‐1 grafted peptide can be used to design stable peptides for therapeutic purposes by grafting organic functional groups and amino acids. However, when a similar strategy was used with another grafted peptide, the resulting peptide did not produce a single major conformation, and its biological activity was lost. Thus, conformational constraints depend on the sequence of amino acids used for SFTI‐1 grafting.
Multiparametric MRI radiomics in prostate cancer for predicting Ki-67 expression and Gleason score: a multicenter retrospective study
Authors: Zhou Chuan , Zhang Yun-Feng , Guo Sheng , Wang Dong , Lv Hao-Xuan , Qiao Xiao-Ni , Wang Rong , Chang De-Hui , Zhao Li-Ming , Zhou Feng-Hai 
Published: July 2023

Abstract
Purpose
Prostate cancer (PCa) with high Ki-67 expression and high Gleason Scores (GS) tends to have aggressive clinicopathological characteristics and a dismal prognosis. In order to predict the Ki-67 expression status and the GS in PCa, we sought to construct and verify MRI-based radiomics signatures.

Methods and materials
We collected T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) images from 170 PCa patients at three institutions and extracted 321 original radiomic features from each image modality. We used support vector machine (SVM) and least absolute shrinkage and selection operator (LASSO) logistic regression to select the most informative radiomic features and built predictive models using up sampling and feature selection techniques. Using receiver operating characteristic (ROC) analysis, the discriminating power of this feature was determined. Subsequent decision curve analysis (DCA) assessed the clinical utility of the radiomic features. The Kaplan–Meier (KM) test revealed that the radiomics-predicted Ki-67 expression status and GS were prognostic factors for PCa survival.

Result
The hypothesized radiomics signature, which included 15 and 9 selected radiomics features, respectively, was significantly correlated with pathological Ki-67 and GS outcomes in both the training and validation datasets. Areas under the curve (AUC) for the developed model were 0.813 (95% CI 0.681,0.930) and 0.793 (95% CI 0.621, 0.929) for the training and validation datasets, respectively, demonstrating discrimination and calibration performance. The model's clinical usefulness was verified using DCA. In both the training and validation sets, high Ki-67 expression and high GS predicted by radiomics using SVM models were substantially linked with poor overall survival (OS).

Conclusions
Both Ki-67 expression status and high GS correlate with PCa patient survival outcomes; therefore, the ability of the SVM classifier-based model to estimate Ki-67 expression status and the Lasso classifier-based model to assess high GS may enhance clinical decision-making.