bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laryngeal mask versus intubation on adverse reactions in pediatric retinoblastoma patients
Authors: Huo Fei , Liang Hansheng , Gao Lan , Liang Jianhong , Liu Huixin , An Haiyan 
Published: July 2023

Abstract
Purpose
The objective of this study was to compare the effect and safety of laryngeal mask airway (LMA) versus endotracheal intubation(ETT) in children undergoing nucleation surgery.
Methods
A retrospective review of consecutive patients in the tetriary hospital from 2007 to 2020 who received eye removal surgery were included in our study. Fifty-eight eligible patients were divided into Group A (ETT, n = 35) and Group B (LMA, n = 23) according to the type of anesthesia. Patients’ demographic materials were recorded and analyzed. The heart rate (HR) and mean arterial pressure (MAP) were retrieved at different time point. The perioperative complications were also collected.
Results
39.66% (23/58) of patients received LMA. The patients with LMA placement in Group B showed significantly lower heart rate before skin incision than those receiving ETT in Group A (P < 0.05).In Group B, one patient experienced laryngeal spasm after the removal of the laryngeal mask, and one patient experienced second attempt of LMA insertion due to poor alignment of laryngeal mask at the first time.
Conclusion
LMA intubation provides more stable perioperative conditions for children undergoing eye enucleation surgeries. LMA intubation does not generate more adverse events than ETT.
First records of Chionodraco hamatus nests in coastal areas of Terra Nova Bay (Ross Sea): a potential nesting area for the species?
Authors: Carlig Erica , Blasi Davide Di , Canese Simonepietro , Vacchi Marino , Grant Susie , Ghigliotti Laura 
Published: July 2023

Abstract
Nests of the icefish Chionodraco hamatus were documented for the first time at about 500 m depth at Terra Nova Bay (Victoria Land, western Ross Sea), in an area included in the Antarctic Specially Protected Area (ASPA) No. 173 and in the portion with more stringent protection of the largest established marine protected area of the world, the Ross Sea Region Marine Protected Area (RSRMPA). Nest building and eggs guarding are common parental care behaviours in the Antarctic icefishes (Channichthyidae). Prior to present work, nest building behaviour for C. hamatus was observed only in the frame of aquarium experiments. Here we report on the observation of five nests of C. hamatus by remote underwater video systems in November 2021, during an Italian Antarctic expedition. The nests, consisting of gravel and small stones, were circular and bowl-shaped with a consistent diameter of about 30–40 cm. Nest building behaviour, with the icefish individual alternating radial turns in clockwise and counter-clockwise movements was also recorded in situ for the first time. By considering the occurrence of the icefish nests, as well as biotic and abiotic features of the locality, the existence of a C. hamatus nesting area is hypothesised. If confirmed, the occurrence of an icefish nesting area in Silverfish Bay would further strengthen the ecological value of the ASPA 173. Furthermore, documenting nesting icefish in nearshore coastal areas of the RSRMPA reinforces the relevance of the MPA itself and provides an important focus for future research and monitoring in the area.
Occult methemoglobinemia in a medically-complex child and the opportunity for pharmacist intervention in the pediatric population
Authors: Walsh Kendra L. , Silva Christian R. , Lee Patrick H. 
Published: July 2023

Abstract
Background
Methemoglobinemia is a rare, yet life-threatening disorder that occurs due to an accumulation of methemoglobin in the blood. The clinical presentation often includes dyspnea, cyanosis, and hypoxemia that shows little improvement with the administration of supplemental oxygen. Ester anesthetics, including benzocaine ,are among the most notorious agents for causing this condition in children. The United States (US) Food and Drug Administration (FDA) warns against the administration of benzocaine to those younger than two years old and urges manufacturers to add a statement regarding the development of methemoglobinemia to the packaging of any products containing this ingredient.
Case Presentation
The objective of this article is to summarize the unique constellation of signs and symptoms observed in a seven-year-old child subsequently diagnosed with benzocaine-induced methemoglobinemia. Additionally, we emphasize the value of utilizing pharmacists as part of an interdisciplinary team when caring for pediatric patients.
Conclusion
Providers should recognize that methemoglobinemia may occur in toddlers and children outside of the FDA’s specific age warning window and must keep a broad differential for patients presenting with respiratory distress.
Assessing Coastal Erosion and Sediment Removal in the sand bar of the Isla Salamanca: Implications for the Barranquilla-Ciénaga Highway and coastal marine biodiversity – Colombia
Authors: Manzolli Rogerio Portantiolo , Cantillo-Sabalza Mulfor , Portz Luana 
Published: July 2023

Abstract
The behavior of the shoreline is one of the most changing environments on the earth's surface, characterized by the effects of coastal progradation and erosion. In the Colombian Caribbean coast there are erosive tendencies causing negative coastal morphological changes due to a marked anthropic influence. The objective of the research was to analyze the evolutionary trend of the coastline and quantify the volume of sediments removed from the beach profile, correlating the risks associated with the loss of coastal marine biodiversity in Isla Salamanca National Park. The analysis of shoreline and volume variation will be carried out in GIS using Google Earth Pro satellite images (2004, 2010, 2013, 2015, 2019 y 2021) and photogrammetric orthomosaics taken with a drone (10/2020-07/2021). From the DSM analysis it was possible to quantify the volume of sediment removed in the two sectors. Erosional processes along the Isla Salamanca coastal barrier have an average annual rate of coastal transgression of -4.8 m·yr-1, with an average retreat of -82.8 m from the shoreline. Especificamente, a análise de curto prazo mostrou que no km 29 as taxas erosivas, assim como o volume de sedimento remobilizado, são menores que nos dois setores do km 19. This heterogeneous behavior is probably associated with the lack of sediment supply east of the barrier and due to the presence of the seawall and the little slope of the coast, causing part of the sediment that reaches km 19 Sector 1 by the coastal drift to be lost to the surf zone. The protection of the highway by the breakwater at km 19 only works as a temporary protection of the highway and does not neutralize the erosive phenomenon. Erosive processes along the coastal barrier of Isla Salamanca are natural and irreversible phenomena that are directly affecting the ecosystems and marine-coastal biodiversity of Isla Salamanca National Park. However, anthropic interventions in the coastal environment can accelerate these erosive processes. An uncharacterized the landscape which, added to the natural erosive processes, produce a risk to this sensitive wetland environment. There are a variety of possible actions to reduce the effect of changes in the landscape of the Isla Salamanca Natural Park, with road relocation as a priority.
Evaluating the impacts of anthropogenic, climate, and land-use changes on streamflow
Authors: Ruigar Hossein , Emamgholizadeh Samad , Gharechelou Saeid , Golian Saeed 
Published: July 2023

Abstract
Surface water resources and their contribution to the water balance components are crucial for effective water resource utilization and management in arid and semi-arid regions. Several factors, including natural and human-induced, can affect river discharge. This study aims to examine the influence of land use changes and climate variations on the monthly average rainfall time series in the Talar River basin, situated in the central Alborz watershed in northern Iran. To investigate the impact of human factors, namely land use change and point source operations, on monthly average streamflow, the DBEST (Detecting Breakpoints and Estimating Segments in Trend) method was used to detect any breakpoint in the streamflow time series caused by gradual changes in land use and climate. The Soil and Water Assessment Tool (SWAT) model was used to simulate the basin at two stations, Kiakola and Shirghah, between 2001 and 2020. The model setup for this study used various datasets, including a Digital Elevation Model (DEM), hydrological and meteorological data, stream network, land use maps, soil texture maps, and point source operations parameters. The land use maps were created by integrating data from Landsat 5 and 8 and MODIS satellites for the years 2001 and 2019. Calibration and validation at the Kiakola station showed that the Nash-Sutcliffe model (NSE) had an efficiency of 0.8 and 0.76, respectively, while at the Shirghah station, the same values were 0.84 and 0.75. The SWAT model yielded satisfactory results, enabling the contribution calculation of climate change factors, land use changes, and point source operations on water levels in the basin. Findings revealed that human activities, specifically the combined impact of land use change and point source operations, had a 60% influence on the monthly average streamflow of the Talar River. Further analysis comparing the relative contributions of the three influential factors showed that the combination of land use changing and water harvesting played the most significant role in altering the basin's outflow on a monthly scale.
Norovirus infection among HIV patients in Abuja, Nigeria: impact of Highly Active Antiretroviral therapy status
Authors: Osazuwa Favour , Johnson William Olayemi , Grobler Hailey Seth 
Published: July 2023

Abstract
Background
Norovirus is now recognized to be major cause of gastroenteritis worldwide, with significantly higher disease burden among immunocompromised patients. This study aimed to determine the prevalence of Norovirus among HIV patients and to evaluate the impact of Highly active antiretroviral therapy (HAART) status on Norovirus prevalence in a sub-urban area of Abuja, Nigeria.
Methods
This study included a total of Two hundred and fifteen subjects (85 HAART-naïve and 130 HAART-exposed) HIV patients. Age range of study participants was 18 to 60 years. Faecal specimens where collected in screw capped containers and analyzed for Norovirus using Accupower Norovirus real-time PCR Test kit. CD4 cell count was determined using flow cytometry.
Results
The prevalence of Norovirus among HAART-naïve HIV patients was 10.6%. Age and gender was not associated with norovirus infection. HAART –naïve HIV patients with CD4 cell count < 200 was significantly more infected with Norovirus as compared to those with CD4 count ≥ 200 (OR: 28.000, 95% CI 3.2237, 243.2007, P = 0.0025). Norovirus was also found to be significantly higher in HAART-naïve HIV patients than amongst HAART-exposed counterparts (OR: 6.882, 95% CI: 1.4514, 32.6343, P = 0.015).
Conclusions
The prevalence of Norovirus among HAART-naïve HIV patients was high; and was significantly higher in subjects with low CD4 counts. Screening for Norovirus among HAART-naïve HIV patients is however emphasized to allow for effective Norovirus disease management.
Determination of silicon content in metallurgical-grade silicon refined slag using two-step dissolution chemical analysis method
Authors: Tan Ning , Han Shifeng , Wei Kuixian , Ma Wenhui 
Published: July 2023

Abstract
Under the demand of global green and low-carbon development, it is urgent to recycle silicon from metallurgical-grade silicon refined slag (MGSRS). Content of elemental silicon (Si) in MGSRS is the key of silicon recovery, and directly affects the selection and economic value of the silicon recovery technology. In this study, a two-step dissolution chemical analysis method is proposed to separate and determine the silicon and other silicon phases content of MGSRS. First, the silicate in the MGSRS was dissolved by hydrochloric acid to obtain the silicate content, and mixed particles containing silicon and silicon carbide (SiC) were separated. Second, silicon was dissolved by a mixture of nitric and hydrofluoric acid (HF/HNO3), and the SiC particles were separated, then the Si and SiC content were determined respectively. During the two steps, the dissolution effect and repeatability of silicate and silicon with different acid was studied. Finally, The silicon content in MGSRS measured by the two-step chemical method was 21.84±0.53%, under the condition of volume ratio of HNO3:HF is 1:1 and reaction time is 1h. This method breaks the situation that the content of elemental silicon in MGSRS is estimated only by experience. It has a positive impact on the further development of silicon recovery from MGSRS and can reduce environmental pollution.
Exploring the environmental economic impact of Fruits and vegetable loss quantification in the food industry
Authors: Sabiha BECHIR , Oualid LACHI , Lamia TAOUZINET , Lynda MESSAOUDENE , Ayoub ALLAM , Khodir MADANI , mohammed kamel si 
Published: July 2023

Abstract
For many years, population growth has stimulated rising demand for both agro-food products and economic activity which has had a bad influence on impact on the ecosystem and the co non-renewable consumption. Algeria confronts the monumental challenge of choosing how to effectively nourish everyone on a more congested globe. However, food loss is a significant issue that is getting worse as Algerian’s population continues to expand and food consumption is increasing. In Algeria, food production and processing of food items, which include fruits, vegetables, and cereals, generate a considerable amount of by-products, with no commercial exploitation and a negative environmental impact, generating enormous socio-economic problems. These byproducts are essential sources of products with high levels of added value that can be applied in different sectors. Our research objective is to quantify the loss in the Algerian food industry, generated by the transformation of various agricultural products, which directly affects the economy and food availability for the population. The research utilizes a mixed-methods approach, including coefficients, production statistics transformed, and data analysis, It is the first research to measure the scope of food waste. in the Algerian food industry. The findings reveal that a significant portion of fruits and vegetables are lost in the Algerian food industry, suggesting that minimizing food loss can help companies to minimize costs and mitigate the adverse environmental effects of food production. Finally, the study proposes practical options to minimize food loss to create a long-term food system in Algeria.
Developing a new Artificial Intelligence framework to estimate the thalweg of rivers
Authors: Aghamolaei Zohre , Kermani Masoud Reza Hessami 
Published: July 2023

Abstract
Hydrographic operations to investigate the riverbed form throughout the entire length of a river are costly and time-consuming. This has made scholars use a wide range of alternative methods to address the issue. In the present study, however, a new framework using Artificial Intelligence- (AI-) based models is introduced to identify the thalweg of rivers, which provides an accurate estimate of a river thalweg via linking coordinates of their left and right banks. In this regard, we trained and tested the performance of two AI-based models, including Artificial Neural Network (ANN) and Adaptive Neuro-Fuzzy Inference System (ANFIS) models. The database of two rivers, namely the Qinhe River in China and the Gaz River in Iran was used to help evaluate the developed model. Outcomes of the two investigated case studies demonstrated that the values of the statistical error estimators, including the Root Mean Square Error (RMSE) of the ANFIS model were less than those of the ANN model. As a result, the ANFIS model can lead to more accurate results than the ANN model, and it is suitable for cases with less available data. Moreover, comparing the results from the developed models with those of the River Channel Morphology Model (RCMM) showed that AI-based models outdo numerical approaches in the identification of the thalweg of rivers. All in all, it is inferred that the proposed approach not only helps us achieve an accurate geometry of rivers but reduces the side costs and can be used as an effective alternative to field operations.
A single NLR gene confers resistance to leaf and stripe rust in wheat
Authors: Sharon Amir , Sharma Davinder , Avni Raz , Gutierrez-Gonzalez Juan , Kumar Rakesh , Sela Hanan , Prusty Manas , Cohen Arava , Molnar Istvan , Holušová Kateřina , Said Mahmoud , Doležel Jaroslav , Millet Eitan , Khazan Sofia , Landau Udi , Bethke Gerit , Ezrati Smadar , Ronen Moshe , Maatuk Oxana , Eilam Tamar , Manisterski Jacob , Ben-Yehuda Pnina , Anikster Yehoshua , Matny Oadi , Steffenson Brian , Mascher Martin , Brabham Helen , Moscou Matthew , Liang Yong , Yu Guotai , Wulff Brande , Muehlbauer Gary , Minz-Dub Anna 
Published: July 2023

Abstract
Nucleotide-binding site leucine-rich repeat (NLR) disease-resistance genes typically confer resistance against races of a single pathogen. We report that Lr/Yr548, an NLR gene from Aegilops sharonensis and Aegilops longissima, confers specific resistance against Puccinia triticina (Pt) and P. striiformis tritici (Pst) that cause leaf and stripe rust, respectively. Lr/Yr548 prevented disease development in wheat introgression as well as transgenic wheat lines. Comparative analysis of Lr/Yr548 and all cloned Triticeae NLR disease-resistance genes showed that Lr/Yr548 contains a distinctive coiled-coil domain and that it is unique to Ae. sharonensis and Ae. longissima. A phylogenetic analysis indicated multiple events of gene flow of Lr/Yr548 between the two species, and suggested loss of resistance in susceptible isolates. The confinement of Lr/Yr548 to Ae. longissima and Ae. sharonensis and the cross resistance that it confers against Pt and Pst in wheat highlight the potential of these species as sources of novel disease-resistance genes for wheat improvement.
Integration of metabolomics and transcriptomics reveals the therapeutic mechanism underlying Chelidonium majus L. in the treatment of allergic asthma
Authors: Wang Renguang , Sui Xintong , Dong Xin , Hu Liming , Li Zhimeng , Yu Hang , Li Cuicui , Ji Guoxin , Wang shumin 
Published: July 2023

Abstract

Background
Chelidonium majus L. (C. majus) belongs to the Papaveridae family and is the dried whole grass of C. majus. It is usually used in clinical practice of traditional Chinese medicine and has been reported of the effect in relieving cough and asthma. However, the mechanism of action is still unknown. This research aimed to illuminate the therapeutic effect of C. majus in the inhibition of allergic asthma.
Methods
Asthmatic SD rats were first sensitized and established through ovalbumin (OVA) motivation. Subsequently, lung histopathological analysis (HE, Masson, PAS) and inflammatory cytokines assay (IL-4, IL-17, IL-6) were implemented to evaluate the protective effects of C. majus on asthma. Then, the effects of C. majus and their molecular mechanisms of action on asthma were detected based on the integration of transcriptomics and metabolomics analyses.
Results
After administration with C. majus, the histological injury of inflammation, collagen deposition and mucus secretion in lungs were attenuated and the serum inflammatory cytokines perturbations were also converted. Furthermore, integrated analysis revealed that after C. majus treatment, 7 different expression genes (DEGs) (Alox15, P4ha1, Pla2g16, Pde3a, Nme1, Entpd8 and Adcy9) and 9 metabolic biomarkers (ADP, Xanthosine, Hypoxanthine, Inosine, prostaglandin E2 (PGE2), prostaglandin F2a (PGF2a), phosphatidylserine, Creatine and LysoPC(10:0)) were discovered to be connected with the enrichment metabolic pathways, including Purine metabolism, Arachidonic acid metabolism, Arginine and proline metabolism and Glycerophospholipid metabolism. The obtained metabolic biomarkers and DEGs are mainly related to energy metabolism and inflammation, and may be potential therapeutic targets.
Conclusion
C. majus relieved OVA-induced asthma in rats by regulating the Alox15, P4ha1, Pla2g16, Pde3a, Nme1, Entpd8 and Adcy9 genes expression to restore the disorders in energy metabolism and inflammation.
Interpretable joint clustering of single-cell transcriptomes
Authors: Madsen Jesper , Møller Andreas 
Published: July 2023

Abstract
Single-cell and single-nucleus RNA-sequencing (sxRNA-seq) is increasingly being used to study and deepen our understanding of the transcriptomic state of cell types in tissues at homeostasis, how they develop and how they are shaped by diseases. However, finding affected cell types and identifying regulated genes can be challenging, as biological effects can be masked by technical variation. Here, we present JOINTLY, an algorithm for joint clustering of sxRNA-seq datasets across batches. Unlike existing state-of-the-art methods, JOINTLY is interpretable, identifying gene programs active across batches and robust against over-correction, retaining subtle cell state differences between biological conditions. By benchmarking across 5 tissues and 52 samples, we show that JOINTLY performs as well as or better than current state-of-the-art batch integration methods in clustering tasks and significantly outperforms other interpretable models. We demonstrate the robustness of JOINTLY to retain biological variation by integrating datasets from different tissues with tissue-specific endothelial cell states and showcase how JOINTLY’s interpretable factors can be used to annotate cell types and identify active signalling programs. Finally, we use JOINTLY to create a reference atlas of white adipose tissue (WATLAS) from 6 multi-donor studies. WATLAS is an expandable and comprehensive com-munity resource, which we use to describe four different populations of adipocytes and map compositional changes in obesity and between white adipose tissue depots.
Clinical and molecular characteristics, transcriptome, and drug efficacy of ERBB2 tyrosine kinase and non-tyrosine kinase mutations in non-small cell lung cancer
Authors: zheng xiaopan , Li Haitao , Ying Haoxuan , Cao Manming , Zhu Weiliang , Wu Xiaowen , Wei ting 
Published: July 2023

Abstract
ERBB2 mutations in the tyrosine kinase domain (TKD) have been widely reported in non-small cell lung cancer (NSCLC). More and more non-tyrosine kinase domain (non-TKD) mutations of ERBB2 have been detected. However, the clinical effects of non-TKD mutations are still unknown. Therefore, this study aims to study the molecular and clinical characteristics, transcriptome differences, and sensitive drugs of TKD and non-TKD mutations in NSCLC. Gene mutation, RNA sequencing, and clinical information of NSCLC with ERBB2 mutations were downloaded. Bioinformatics methods, such as gene mutation analysis, differentially expressed genes (DEGs), functional enrichment analysis, protein-protein interaction (PPI), hub gene identification, and drug sensitivity analysis, were adopted. Finally, four patients were included to reflect the treatment response. The somatic mutation rate of ERBB2 was 3.2%. TKD and non-TKD mutations mainly occurred in lung adenocarcinoma. Non-TKD mutations have a better prognosis. Up-regulated DEGs are primarily involved in immune and inflammatory pathways. We then proved that BTK, LYN, and PIK3CA mutations have a better prognosis than wild type in patients of NSCLC. The drug sensitivity study found that the TKD group was more sensitive to 5 drugs, and the non-TKD was 28.TKD and non-TKD mutations identify two independent subsets of ERBB2 mutations in NSCLC. Non-TKD mutations have a better prognosis and can also be used as targets for ERBB2. Our study can provide a foundation for further clinical research, highlighting the importance of individualized treatment for patients with different mutation domains.