bluuebunny/crossref_metadata_2025_split huggingface dataset:
The health gap and HRQoL inequalities in Greece before and during the economic crisis
Authors: Yfantopoulos John , Chantzaras Athanasios , Yfantopoulos Platon 
Published: June 2023

ObjectiveThe aim of this study was twofold: (i) to assess the health gap among young socio-economic groups generated by the economic crisis in Greece and (ii) to investigate HRQoL (Health Related Quality of Life) inequalities using the Theil index.MethodsThe EQ-5D-5L instrument was administered to a sample of 4,177 young individuals in Greece, mean age 22.3 (±SD 4.8) and 53.8% males, and 46.2% females. The Greek version of the EQ-5D-5L instrument was used in a web-based questionnaire to collect data. Subjects were asked to assess their subjective health status during the economic crisis of 2016 using the EQ-5D-5L instrument, and to recall their health before the crisis of 2009. The health gap was assessed on a Visual Analogue Scale (EQ-VAS), the EQ-5D-5L Index, and the five dimensions of the EQ-5D-5L instrument. Regression analysis was employed to measure the effects of the economic crisis on age, sex, education, and income on the EQ-VAS and EQ-5D-5L. Theil index was used to assess HRQoL inequalities.ResultsThe economic crisis brought a significant deterioration in the HRQoL of young Greeks. The EQ-VAS was reduced during the crisis by −10.05% (p &lt; 0.001) and the EQ-5D-5L index declined by −19.61% (p &lt; 0.001). The prevalence of the health gap in each dimension of the EQ-5D-5L was also significant in terms of deterioration of Mobility [change by 66.8% (p &lt; 0.001)], Self-care [change by 61.0% (p &lt; 0.001)], Usual activities [change by 97.1% (p &lt; 0.001)], Pain/discomfort [change by 65.0% (p &lt; 0.001)], and Anxiety/depression [change by 70.5% (p &lt; 0.001)]. Significant reductions in EQ-5D-5L indices were also associated with greater inequalities in the distribution of health among age, gender, income, and educational groups. The EQ-5D-5L health gap among the poor was much greater (0.198), in comparison to richer (0.128) classes. Similar gaps were also found in terms of educational inequalities. The EQ-5D-5L health gap among those with primary education was 0.211, whereas for those with tertiary education it was 0.16. The Theil index indicated an increase in income-related HRQoL inequalities by 222.3% for the EQ-5D-5L index and by 124.2% for the EQ-VAS. The effects of demographic and socioeconomic variables on the EQ-VAS were found statistically significant: sex (p &lt; 0.05), age (p &lt; 0.001), education (p &lt; 0.001), and income (p &lt; 0.001).ConclusionThe EQ-5D-5L instrument appears to be a powerful tool in assessing the health gap and the HRQoL inequalities among young people in Greece. The findings indicate the importance of developing effective health policies to combat inequalities and mitigate the impact of austerity measures on the quality of life of the young.
Tooth loss, denture use, and all-cause and cause-specific mortality in older adults: a community cohort study
Authors: Dai Miao , Song Quhong , Lin Taiping , Huang Xiaohong , Xie Yufang , Wang Xiang , Zheng Liwei , Yue Jirong 
Published: June 2023

ObjectivesThe available evidence on the connections between tooth loss, denture use, and mortality from all causes or specific causes among older adults is inconclusive. Therefore, we aimed to investigate the association between tooth loss, denture use, and all-cause and cause-specific mortality in older adults.MethodsA cohort of 5,403 participants aged 65 and older were recruited in the 2014 Chinese Longitudinal Healthy Longevity Survey wave and followed up in the 2018 wave. Cox proportional hazard models were used to examine the association between the number of natural teeth, denture use, and all-cause and cause-specific mortality.ResultsDuring a mean (SD) follow-up of 3.1  years (1.3), 2,126 deaths (39.3%) occurred. Individuals with 0 and 1–9 teeth had higher mortality due to all-cause, cardiovascular disease (CVD), cancer, and other causes (all p-trend &lt;0.05) than those with 20+ teeth. At the same time, no association was found with respiratory disease mortality. Participants who used dentures had lower mortality due to all causes [hazard ratios (HR) 0.79, 95% confidence intervals (CI) 0.71–0.88], CVD (HR 0.80, 95% CI 0.64–1.00), respiratory disease (HR 0.66, 95% CI 0.48–0.92), and other causes (HR 0.77, 95% CI 0.68–0.88) than those without dentures. Joint analysis revealed that older adults with fewer natural teeth and no dentures had higher mortality. Additionally, interaction analyses showed that the effects of the number of natural teeth on all-cause mortality were more pronounced in older adults aged &lt;80  years (p-value for interaction = 0.03).ConclusionHaving fewer natural teeth, particularly less than 10 teeth, is linked to an increased risk of mortality from all causes, including CVD, cancer, and other causes, but not respiratory disease. The use of dentures would mitigate the adverse impact of tooth loss on all-cause and some cause-specific mortality.
Evaluation of COVID-19 vaccine implementation in a large safety net health system
Authors: Chen Jennifer C. , Gutierrez Griselda , Kamran Rachel , Terry Jill , Telliyan Armenui , Zaks Camilo , Carson Savanna L. , Brown Arleen , Kim Karen 
Published: June 2023

ObjectivesTo evaluate rapid COVID-19 vaccine clinic implementation from January-April 2021 in the Los Angeles County Department of Health Services (LACDHS), the second-largest US safety net health system. During initial vaccine clinic implementation, LACDHS vaccinated 59,898 outpatients, 69% of whom were Latinx (exceeding the LA County Latinx population of 46%). LACDHS is a unique safety net setting to evaluate rapid vaccine implementation due to system size, geographic breadth, language/racial/ethnic diversity, limited health staffing resources, and socioeconomic complexity of patients.MethodsImplementation factors were assessed through semi-structured interviews of staff from all twelve LACDHS vaccine clinics from August-November 2021 using the Consolidated Framework for Implementation Research (CFIR) and themes analyzed using rapid qualitative analysis.ResultsOf 40 potential participants, 25 health professionals completed an interview (27% clinical providers/medical directors, 23% pharmacist, 15% nursing staff, and 35% other). Qualitative analysis of participant interviews yielded ten narrative themes. Implementation facilitators included bidirectional communication between system leadership and clinics, multidisciplinary leadership and operations teams, expanded use of standing orders, teamwork culture, use of active and passive communication structures, and development of patient-centered engagement strategies. Barriers to implementation included vaccine scarcity, underestimation of resources needed for patient outreach, and numerous process challenges encountered.ConclusionPrevious studies focused on robust advance planning as a facilitator and understaffing and high staff turnover as barriers to implementation in safety net health systems. This study found facilitators that can mitigate lack of advance planning and staffing challenges present during public health emergencies such as the COVID-19 pandemic. The ten identified themes may inform future implementations in safety net health systems.
Notes to the Taxonomic Affiliation of the Bulbophyllym Sect. Physometra (Orchidaceae, Epidendroideae) Based on Molecular Phylogenetic Analyses
Authors: Nowak Sławomir , Olędrzyńska Natalia , Szlachetko Dariusz L. , Dudek Magdalena 
Published: June 2023

To solve the taxonomic affiliation of Bulbophyllum physometrum, the only known species of the Bulbophyllym sect. Physometra (Orchidaceae, Epidendroideae), we conducted phylogenetic analyses based on nuclear markers, i.e., ITS and the low-copy gene Xdh, and the plastid region matK. We used Asian Bulbophyllum taxa, with a special focus on species from the sections Lemniscata and Blepharistes, i.e., the only Asian sections of this genus with bifoliate pseudobulbs, as in B. physometrum. Unexpectedly, the results of molecular phylogenetic analyses showed that B. physometrum is most probably more related to the representatives of the sections Hirtula and Sestochilos than Blepharistes or Lemniscata.
Novel BODIPY Conjugates with Myrtenol: Design, Spectral Characteristics, and Possibilities for Practical Application
Authors: Guseva Galina B. , Antina Elena V. , Berezin Mikhail B. , Nikitina Liliya E. , Gilfanov Ilmir R. , Pavelyev Roman S. , Lisovskaya Svetlana A. , Frolova Larisa L. , Ostolopovskaya Olga V. , Rakhmatullin Ilfat Z. , Klochkov Vladimir V. , Trizna Elena Y. , Kayumov Airat R. 
Published: June 2023

The synthesis of new fluorescent probes, based on biocompatible luminophors and exhibiting various specificities, is intensively developed worldwide. Many luminophors contain a hydrophobic group that limits their application for cell staining under vital conditions. Herein, we report the synthesis of two BODIPY molecules—BF2-meso-(4-butan/pentanamido-N-(((1S,5R)-6,6-dimethylbicyclo [3.1.1]hept-2-en-2-yl)methyl)-N,N-dimethylpropan-1-aminium)-3,3′,5,5′-tetramethyl-2,2′-dipyrromethene bromides—designed as 10, 11 with a spacer of either four or three CH2 groups in length, respectively. These molecules present conjugates of BODIPY luminophors with (+)-myrtenol via a quaternary ammonium group. Both terpene-BODIPY conjugates demonstrated high fluorescence efficiency in various solvents such as OctOH, DMSO and water, and were characterized by their stability at pH 1.65–9.18. The fusion of the myrtenol, a monocyclic terpene, to the BODIPY fluorophore in the meso-substituent facilitated their penetration into the filamentous fungi Fusarium solani, while impairing the binding of the latter with S. aureus, K. pneumoniae and P. aeruginosa. The additional quaternary ammonium group between the myrtenol and fluorophore moieties restored the bacterial cell-staining while it did not affect the staining of fungi. Finally, the BODIPY conjugate 11 was able to stain both Gram-positive and Gram-negative bacteria by its interaction with their cell wall (or the membrane), as well as penetrating into filamentous fungi F. solani and staining their mitochondria.
Patient enablement and health-related quality of life for patients with chronic back and knee pain: a cross-sectional study in primary care
Authors: Ng Amy Pui Pui , Cheng John King Yiu , Lam Joyce Sau Mei , Wong Carlos King Ho , Cheng Will Ho Gi , Tse Emily Tsui Yee , Chao David Vai Kiong , Choi Edmond Pui Hang , Wong Rosa Sze Man , Lam Cindy Lo Kuen 
Published: June 2023

BackgroundChronic back and knee pain impairs health- related quality of life (HRQoL) and patient enablement can improve HRQoL.AimTo determine whether enablement was a moderator of the effect of chronic back and knee pain on HRQoL.Design and settingA cross-sectional study of Chinese patients with chronic back and knee problems in public primary care clinics in Hong Kong.MethodEach participant completed the Chinese Patient Enablement Instrument-2 (PEI-2), the Chinese Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Pain Rating Scale (PRS). Multivariable regression examined the effects of PRS score and PEI-2 score on WOMAC total score. A moderation regression model and simple slope analysis were used to evaluate whether the interaction between enablement (PEI-2) and pain (PRS) had a significant effect on HRQoL (WOMAC).ResultsValid patient-reported outcome data from 1306 participants were analysed. PRS score was associated with WOMAC total score (β = 0.326,P<0.001), whereas PEI-2 score was associated inversely with WOMAC total score (β = −0.260,P<0.001) and PRS score. The effect of the interaction between PRS and PEI-2 (PRS × PEI-2) scores on WOMAC total score was significant (β = −0.191,P<0.001) suggesting PEI-2 was a moderator. Simple slope analyses showed that the relationship between PRS and WOMAC was stronger for participants with a low level of PEI-2 (gradient 3.056) than for those with a high level of PEI-2 (gradient 1.746).ConclusionPatient enablement moderated the impact of pain on HRQoL. A higher level of enablement can lessen impairment in HRQoL associated with chronic back and knee pain.
Essai de recherche des objectifs macroéconomiques. Application de l'analyse factorielle
Authors: Echard Jean-François 
Published: June 2023

The induction of economic laws from direct analysis of facts implies that a specific methodological problem has to be tackled with. The search of regularities requires the use of adequate typological methods : factor analysis is the one we have selected to exhibit the « revealed » goals of macroeco- nomic activity.
After a survey focused on implicit hypotheses and the rationality of the factorial method, we give the issues of the research of the goals in the French case, and we suggest possible developments concerning the causal analysis of observed phenomena.
Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer’s Disease
Authors: Huang Qianqian , Jiang Chaoqing , Xia Xue , Wang Yufan , Yan Chenxing , Wang Xiaorong , Lei Ting , Yang Xiaotong , Yang Wenqin , Cheng Guo , Gao Huile 
Published: June 2023

Inflammatory responses, manifested in excessive oxidative stress and microglia overactivation, together with metal ion-triggered amyloid-beta (Aβ) deposition, are critical hallmarks of Alzheimer’s disease (AD). The intricate pathogenesis causes severe impairment of neurons, which, in turn, exacerbates Aβ aggregation and facilitates AD progression. Herein, multifunctional melanin-like metal ion chelators and neuroinflammation regulators (named PDA@K) were constructed for targeted treatment of AD. In this platform, intrinsically bioactive material polydopamine nanoparticles (PDA) with potent metal ion chelating and ROS scavenging effects were decorated with the KLVFF peptide, endowing the system with the capacity of enhanced pathological blood–brain barrier (BBB) crossing and lesion site accumulation via Aβ hitchhiking. In vitro and in vivo experiment revealed that PDA@K had high affinity toward Aβ and were able to hitch a ride on Aβ to achieve increased pathological BBB crossing. The engineered PDA@K effectively mitigated Aβ aggregate and alleviated neuroinflammation. The modulated inflammatory microenvironment by PDA@K promoted microglial polarization toward the M2-like phenotype, which restored their critical functions for neuron care and plaque removal. After 3-week treatment of PDA@K, spatial learning and memory deficit as well as neurologic changes of FAD
4T
transgenic mice were largely rescued. Transcriptomics analysis further revealed the therapeutic mechanism of PDA@K. Our study provided an appealing paradigm for directly utilizing intrinsic properties of nanomaterials as therapeutics for AD instead of just using them as nanocarriers, which largely widen the application of nanomaterials in AD therapy.
Implementasi Model Pembelajaran Kontekstual dengan Media Talking Stick untuk Menumbuhkan Karakter Profil Pelajar Pancasila dalam Mata Pelajaran PPKN
Authors: Andriani Rismalinda , Inayah Ivatun Nurul , Ahsani Eva Luthfi Fakhru 
Published: June 2023

Kurangnya pemahaman siswa dalam pembentukan karakter profil pelajar Pancasila yang mana terdapat dalam materi norma-norma yang berlaku dikehidupan mata pelajaran PPKn pada kurikulum merdeka belajar yang menekankan pembentukan karakter siswa terutama pada siswa kelas IV SD N 03 Rejosari Kudus. Dalam pemahaman maupun implementasi materi norma-norma yang berlaku dikehidupan belum ditemukan bentuk adanya karakter profil pelajar Pancasila pada kelas IV. Tujuan dari penelitian ini adalah untuk mengetahui implementasi dari pembelajaran kontekstual dengan menggunakan media Talking Stick dalam menumbuhkan karakter profil pelajar Pancasila pada mata pelajaran PPKn di kelas IV melalui sampel 14 siswa. Penelitian yang digunakan peneliti ialah penelitian tindakan kelas atau Action Reseach dengan subyek penelitian siswa kelas IV SD N 03 Rejosari Kudus yang terdiri dari 14 siswa, 6 siswa laki-laki dan 8 siswa perempuan. Hasil dari penelitian ini adalah pada siklus pertama masih dalam kategori kurang sekali dengan presentase 51% sedangkan pada siklus kedua mengalami peningkatan sebanyak 73% dengan kategori cukup.
Efektivitas Pendidikan Kesehatan Video Animasi tentang Pernikahan Dini terhadap Pengetahuan Remaja Putri
Authors: Hanifa Andisetyana Putri  , Shusmitha Sekar Satriani  , Runjati  
Published: June 2023

ABSTRACT
Background: The phenomenon of early marriage during the COVID-19 pandemic that occurred in Batang Regency increased by 200% compared to the previous year with the average age of marriage being 17 years. From 2019 to 2020 there has been a decrease of 0.6%, but it has not yet reached the target of reducing it to 8.74% in 2024. One of the factors causing early marriage is the lack of knowledge of reproductivehealth in adolescents and the risks that can occur due to contraceptives. reproductive organs that are not ready for pregnancy and childbirth. This can increase maternal and infant mortality as a standard for a country's health status. Social and economic impacts also occur due to reduced peer interaction, discontinued education levels, resulting in narrower job opportunities.
Purpose: The aim of this study was to determine the effectiveness of health education through animated video media on young women's knowledge of early marriage during a pandemic at SMA Negeri 1 Batang. This type of research uses a quasi-experimental and pretest-posttest with control design. The sampling technique was simple random sampling with a total of 134 respondents. Data collection used a questionnaire filled out online via the Google form.
Result: The results of the study showed an increase in the average knowledge score in both the control and experimental groups. In the control group, the increase in score reached 12.69 ± 2.211, while in the treatment group it experienced a higher increase, namely 22.55 ± 7.509. The results of the Mann Whitney test showed that providing health education using animated video media was effective in increasing the knowledge of SMA Negeri 1 Batang students with a p value = 0.000.
Keywords: early marriage, animation videos, knowledge
SUB-ACUTE DERMAL TOXICITY OF SODIUM-CONTAINING DRUGS
Authors: Patereha I. , Ostapiuk A. , Kushnir V. , Protsyk Ya. , Pyatnychko O. , Yurynec T. , Chudyak M. , Martynyk S. 
Published: June 2023

Drugs that have antimicrobial, anti-inflammatory and wound-healing effects deserve special attention, sodium-containing drugs are one of them, which is why they are used in veterinary medicine.
The article presents the results of experimental studies to study the sub-acute toxicity of sodium-containing drugs: known – glycetinate 2%, its analogues – ovocid 2%, ovocid 3%, potassium-sodium 1.5% (Na / K, 1.5%).
The study of sub-acute toxicity of drugs was carried out by applying drugs to the skin of animals. The experiment used white rats weighing 250-270 g. 4 groups of rats with 3 animals in each were formed: rats of group I on the skin was applied ovocid 3%, group 2 - Na / K drug 1.5%, 3rd group – ovocide 2%, and the 4th group of rats (control) was applied glycetinate 2%. The animals were subjected to clinical observations, assessing their general condition and skin reaction. The effect of drugs on morphological and biochemical parameters of blood of rats was studied.
Evaluating the general condition, behavior, local skin reaction of rats for the study of subacute toxicity, local irritant action of sodium-containing drugs, it was noted that they did not cause visible violations of physiological functions, the appearance of clinical signs of intoxication. No significant clinical signs of inflammation or irritation (erythema, edema, and cracks) were recorded on the skin of the animals. At the same time, it should be noted that the animals of all experimental groups had a slight redness at the place of application of the drugs, which later disappeared.
GROWING OF ORGANIC FISH IS IN NATURAL POND
Authors: Pustova N. , Pustova Z. , Balickiy D. 
Published: June 2023

The ponds of natural zones is economic activity on the most variety’s in limit, a sent to maximal of ecosystem maintenance – adherent territory to the pond and variety of flora and fauna. To organization of organic fish-farms on the ponds is natural zones creates the swift reduction to the prime price of fish is for a sale and improvement of basic fish economic indexes.

Researches our methodology is envisaged the study of features are growing and productivity of fish in three types: Сarpio, Ctenopharyngodon idella, Hypophthalmichthys in the conditions of natural pond at the organic growing of fish-farming.
Feeding of the Сarpio in a natural pond at the organic growing of fish-farming was begun, when the temperature of water attained +10˚С. For the gradual getting is a fish used to the feed, in places laid into forage out is feed small portions for 2-3 kg. The feeding was distributed once for twenty-four hours of morning oh a 6-7 o'clock, that fish of him used to 12 hour, and in the second half of day she consumed natural forage. The important index of working out of fish is a rate of height, most intensive grew and the greatest average daily increases marked for fishes in the summer months of from 4 to 15 g on a head for twenty-four hours. At the beginning of growing of the Сarpio is consumption of forage on a head for twenty-four hours, were within the limits of a 4-5 g, and maximal a 7 g, showed up in August, when increase under yearling is mainly arrived at due to feeding of forage.
The economic indicators of growing of fishes testify at the terms of natural pond and of organic fish-farms, about the greatest profitability is the Hypophthalmichthys – the 61 percent, in a subzero the Сarpio – 42 percent and on three types of fishes – 52,67 percent. Complex intensification of growing of fish is the scientifically reasonable system of economies of resources and money, is the mortgage of efficient of the economy of organic fish-farms.
THE LEVEL OF POTASSIUM IN THE BLOOD SERUM OF RABBITS WITH EXPERIMENTAL MUSCLE DAMAGE UNDER THE INFLUENCE OF TRANSPLANTED STEM CELLS
Authors: Stadnyk N. V. , Mazurkevich A. I. 
Published: June 2023

In veterinary medicine, limb muscle injuries in sports and working animals, such as tears, sprains, and skeletal muscle damage, are common. These injuries pose challenging problems in animals because traditional treatments are lengthy and not always successful. In animals, skeletal muscles are plastic and dynamic tissues that can adapt to different conditions, such as fiber type changes and hypertrophy, and recover from injuries.
The main purpose of this article is to discuss, analyze and summarize the results of research aimed at the use of allogeneic mesenchymal stem cells, a means of regenerative therapy, in veterinary practice.
The main direction of cell therapy is the use of allogeneic mesenchymal stem cells (MSCs). These cells are undifferentiated and can renew themselves, which allows them to develop into cells with specific functions and become an effective treatment for tissue repair. In particular, mesenchymal stem cells are promising for veterinary medicine, as they are easy to isolate and cultivate and have no ethical issues regarding their use.
The article discusses the application of the analysis of the use of allogeneic mesenchymal stem cells for tissue repair in veterinary medicine in experimental animals, taking into account scientific research and the results of the authors' research.
The use of an innovative and promising method of treating animals with damaged muscle tissue based on cellular regeneration can significantly accelerate the recovery of animals after injury and avoid the side effects that occur with traditional methods of treatment.