bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cost‐effective switched inductor‐based bridgeless Sepic converter for PQ enrichment in power solutions
Authors: Periyathiruvadi Muthu Thiruvengadam , Jothimani Gnanavadivel , Gajendran Marimuthu 
Published: May 2023

SummaryPower solutions contribute a remarkable role in all the sectors. In order to develop the sustainable and affodable power solution, the bettered power quality (PQ) based modified bridgeless switched inductor (MBSL) Sepic power factor correction (PFC) converter is introduced in this article. An added feature to an already existing traditional Sepic converter resulted in switched inductor (SL) network that reasonably improves the step‐down voltage gain with low current stress across the output inductors and diodes which restricts the utilization of transformer that ultimately reduces the overall cost of power solution. This introduced structure acts as a good choice of low‐cost power conversion solution in the perspective of improved inline PQ indices, high efficiency and good reliability. Furthermore, the discontinuous conduction mode (DCM) functioning of SL network reveals the innate zero current switching (ZCS) capability with enhanced efficiency. Besides, the effective functionality of the one‐stage PFC converter is tested on hardware prototype of 250 W/48 V, and it also adopts an appropriate control approach to stabilize the output voltage. This study also exposes small signal modeling to prove the stability of the power solution. In addition, the test outcomes reveal that the preferred PFC procure sinusoidal current from the AC mains that confirms the good enshaping attribute and low current harmonic distortions within the stipulated IEC 61000‐3‐2 standard guidelines for both standstill and fluctuating conditions.
Novel Co5 Cluster Based Triazole Bridged Cobalt‐Fluorophosphate: Synthesis, Structure, Magnetic and Heterogeneous Catalytic Epoxidation Studies
Authors: Sen Rupam , De Sudipta , dos Santos Antonio M. , Escobar Lívia B. L. , Brandão Paula Cristina , Almeida Paz Filipe A. , Reis Mario S. , Lin Zhi 
Published: May 2023

AbstractA novel triazole bridged cobalt fluorophosphate coordination polymer with the formula {Co5(1,2,4‐triazole)2(OH)2(PO3F)4}n has been synthesized. Single crystal X‐ray studies reveal that the compound comprises of Co5 clusters which ultimately build the whole framework, here all cobalt centers are in octahedral geometry established from continuous shape analysis. All the cobalt centers are in Co(II) oxidation state and the results are supported by the bond valence sum (BVS) calculation. The sample has been characterized by single crystal X‐ray, powder X‐ray, FTIR and TGA analysis. The compound was tested for olefin catalysis performance and magnetism. Magnetization measurements reveal overall antiferromagnetic interactions among the Co(II) ions. The compound is very active in the catalytic transformation of olefins to their corresponding epoxides. Catalytic epoxidation studies reveal that cyclohexene and styrene can be converted up to 97 % with almost 65 % selectivity of products with higher TON numbers.
Mesoporous silica/organosilica nanoparticles for cancer immunotherapy
Authors: Theivendran Shevanuja , Lazarev Sergei , Yu Chengzhong 
Published: May 2023

AbstractCancer is one of the fatal diseases in the history of humankind. In this regard, cancer immunotherapeutic strategies have revolutionized the traditional mode of cancer treatment. Silica based nano‐platforms have been extensively applied in nanomedicine including cancer immunotherapy. Mesoporous silica nanoparticles (MSN) and mesoporous organosilica nanoparticles (MON) are attractive candidates due to the ease in controlling the structural parameters as needed for the targeted immunotherapeutic applications. Especially, the MON provide an additional advantage of controlling the composition and modulating the biological functions to actively synergize with other immunotherapeutic strategies. In this review, the applications of MSN, MON, and metal‐doped MSN/MON in the field of cancer immunotherapy and tumor microenvironment regulation are comprehensively summarized by highlighting the structural and compositional attributes of the silica‐based nanoplatforms.
Vascular permeability in HPV+ oropharyngeal cancers aids in fluorescent image‐guided transoral robotic surgery using indocyanine green
Authors: Khurana Nitish , Babajanian Eric , McCrary Hilary , Pulsipher Abigail , Ghandehari Hamidreza , Alt Jeremiah A. , Cannon Richard B. 
Published: May 2023

AbstractBackgroundIndocyanine green (ICG) fluorescent image (FI)‐guided surgery has demonstrated success in improving intraoperative visualization and tumor resections. The objectives were to evaluate the use of IGC in FI‐guided transoral robotic surgery (TORS) and the underlying molecular mechanism.MethodsHPV+ oropharyngeal squamous cell carcinoma (OPSCCa) patient (n = 10) undergoing TORS were enrolled in this prospective study. Participants received intravenous ICG. Excised tissues were evaluated for ICG accumulation, tumor demarcation, and pathological characteristics using In‐vivo imaging system (IVIS), histology, and RNA sequencing.ResultsICG accumulation was significantly increased in primary tumor and pathological lymph nodes compared with normal tissues (p < 0.001). IVIS was 91.3% accurate in identifying OPSCCa in excised tissues; the correlation between IVIS‐ and histologically determined tumor tissues was significant (R2 = 0.8301; p = 0.001). Genes associated with vascular and angiogenic signaling pathways were significantly upregulated in OPSCCa tissues.ConclusionICG effectively demarcates tumor margins in OPSCCa, due to the increased upregulation of genes associated with vascular permeability.
Defining hippocampal area CA2 in the fox (Vulpes vulpes) brain
Authors: Dudek Serena M. , Phoenix Ashley N. , Scappini Erica , Shepeleva Darya V. , Herbeck Yury E. , Trut Lyudmila N. , Farris Shannon , Kukekova Anna V. 
Published: May 2023

AbstractSince 1959, the Russian Farm‐Fox study has bred foxes to be either tame or, more recently, aggressive, and scientists have used them to gain insight into the brain structures associated with these behavioral features. In mice, hippocampal area CA2 has emerged as one of the essential regulators of social aggression, and so to eventually determine whether we could identify differences in CA2 between tame and aggressive foxes, we first sought to identify CA2 in foxes (Vulpes vulpes). As no clearly defined area of CA2 has been described in species such as cats, dogs, or pigs, it was not at all clear whether CA2 could be identified in foxes. In this study, we cut sections of temporal lobes from male and female red foxes, perpendicular to the long axis of the hippocampus, and stained them with markers of CA2 pyramidal cells commonly used in tissue from rats and mice. We observed that antibodies against Purkinje cell protein 4 best stained the pyramidal cells in the area spanning the end of the mossy fibers and the beginning of the pyramidal cells lacking mossy fibers, resembling the pattern seen in rats and mice. Our findings indicate that foxes do have a “molecularly defined” CA2, and further, they suggest that other carnivores like dogs and cats might as well. With this being the case, these foxes could be useful in future studies looking at CA2 as it relates to aggression.
Association of kidney function with cancer incidence and its influence on cancer risk of smoking: The Japan Multi‐Institutional Collaborative Cohort Study
Authors: Kurasawa Shimon , Imaizumi Takahiro , Maruyama Shoichi , Tanaka Keitaro , Kubo Yoko , Nagayoshi Mako , Ikezaki Hiroaki , Suzuki Sadao , Koyama Teruhide , Koriyama Chihaya , Kadota Aya , Katsuura‐Kamano Sakurako , Kuriki Kiyonori , Wakai Kenji , Matsuo Keitaro 
Published: May 2023

AbstractThe association between kidney function and cancer incidence is inconsistent among previous reports, and data on the Japanese population are lacking. It is unknown whether kidney function modifies the cancer risk of other factors. We aimed to evaluate the association of estimated glomerular filtration rate (eGFR) with cancer incidence and mortality in 55 242 participants (median age, 57 years; 55% women) from the Japan Multi‐Institutional Collaborative Cohort Study. We also investigated differences in cancer risk factors between individuals with and without kidney dysfunction. During a median 9.3‐year follow‐up period, 4278 (7.7%) subjects developed cancer. Moderately low and high eGFRs were associated with higher cancer incidence; compared with eGFR of 60‐74 ml/min/1.73 m2, the adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) for eGFRs of ≥90, 75‐89, 45‐59, 30‐44 and 10‐29 ml/min/1.73 m2 were 1.18 (1.07‐1.29), 1.09 (1.01‐1.17), 0.93 (0.83‐1.04), 1.36 (1.00‐1.84) and 1.12 (0.55‐2.26), respectively. High eGFR was associated with higher cancer mortality, while low eGFR was not; the adjusted subdistribution HRs (95% CIs) for eGFRs of ≥90 and 75‐89 ml/min/1.73 m2 were 1.58 (1.29‐1.94) and 1.27 (1.08‐1.50), respectively. Subgroup analyses of participants with eGFRs ≥60 and <60 ml/min/1.73 m2 revealed elevated cancer risks of smoking and family history of cancer in those with eGFR <60 ml/min/1.73 m2, with significant interactions. Our findings suggest that the relationship between eGFR and cancer incidence was U‐shaped. Only high eGFR was associated with cancer mortality. Kidney dysfunction enhanced cancer risk from smoking.
Richard Lerner's Bioinspiration: Biomolecular Visualization and Modeling at Scripps Research
Authors: Olson Arthur J. , Sanner Michel F. , Goodsell David S. , Forli Stefano 
Published: May 2023

AbstractIn thinking back on Richard Lerner's impact on our lab's trajectory at Scripps Research, we see his fingerprints on all the efforts we have undertaken over the last 40 years. Immunology and virology have been a continuing driving focus in our software development and application within the Molecular Graphics Lab (now the Center for Computational Structural Biology – CCSB), spurred on by the marriage of chemistry with biology that Richard enabled at Scripps. Many of our earliest and continuing computational docking targets have been focused on HIV with collaborations with Chi‐Huey Wong and Barry Sharpless. Along with subsequent computational work with Jeff Kelly, Reza Ghadiri, Udi Keinan and Ben Cravatt we have been able to sustain continuous efforts in developing and applying docking and other computational technologies to structural chemistry problems. In this remembrance, we give our reflections of Richard Lerner's character, vision, and his inspiration in our scientific lives and in the environment that he created at Scripps Research.
Educational strategies in oral healthcare for the disabled and their effects on dental students’ training
Authors: Silva Fernanda Luiza , Tavares Sandro Junio de Oliveira , Silveira Flávia Maia , Assaf Andréa Videira 
Published: May 2023

AbstractPurposeTo evaluate the effects of didactic and clinical training of dental students in treating Persons with Disabilities (PwD) on their self‐perceptions about treating PWD.MethodsA pre‐and postevaluation of a didactic‐clinical educational strategy targeting oral health care of PwD was conducted among fourth‐year undergraduate dental students at a Brazilian dental school. Semi‐structured questionnaires were used to assess the following work environment parameters: technical, organizational, social, ethical, and managerial acumen. Data were analyzed using Fisher's exact and chi‐square tests, with a significance level of 5% (p < 0.05), to verify possible associations between the quantitative variables. A qualitative analysis was conducted through collective subject discourse.ResultsSignificant differences were found in the self‐perception of students’ knowledge and abilities in providing low‐complexity care for PwD before and after the training program (p = 0.025). Students were more confident about managing and organizing the work environment (p = 0.007) and providing humanized care to PwD (p = 0.042) posttraining program. Additionally, a decrease in the feeling of insecurity (p = 0.014) and feelings of pity, fear, or prejudice toward PwD (p < 0.001) were observed posttraining program.ConclusionsDidactic and clinical training interventions for treating PwD improved the work environment of undergraduate dental students in technical, managerial, organizational, and ethical/social dimensions.
Improved selectivity of molecularly imprinted polymers based on the synergistic action of hydrogen bond and electrostatic interaction
Authors: Hu Ting , Zhao Qianghong , Wang Ming , Zhou Kai , Xia Zhining , Huang Yike 
Published: May 2023

AbstractBased on the synergistic action of hydrogen bond and electrostatic interaction, provided by methacrylic acid and 2‐aminoethyl ester hydrochloride (FM2), respectively, novel molecularly imprinted polymers (SA‐MIPs) were designed to improve its selective recognition ability. Diclofenac sodium (DFC) was chosen as the template molecule of this study. The interaction and their recognition sites between two functional monomers and templates were confirmed by nuclear magnetic resonance hydrogen spectroscopy. Because of the synergistic action of hydrogen bond and electrostatic interaction, the imprinting factor (IF) of SA‐MIPs (IF = 2.26) is superior to the corresponding monofunctional monomer imprinting materials (IF = 1.52, 1.20) and the materials using two functional monomers with an only single type of interaction (IF = 1.54, 1.75). The results of selective adsorption experiments indicate that the selective recognition ability of SA‐MIPs is significantly better than that of the other four MIPs, and the difference in selectivity coefficient for methyl orange is the largest between SA‐MIPs and the MIPs only using FM2, which is about 70 times. In addition, x‐ray photoelectron spectroscopy was used to verify the interaction between SA‐MIPs and the template. This work and its explanation of the interaction mechanism at the molecular level will be helpful for the rational design of novel MIPs with higher selectivity. Besides, SA‐MIPs have good adsorption performance (37.75 mg/g) for DFC in aqueous solutions, which could be used as potential adsorption materials for the effective removal of DFC in the aquatic environment.
Atmospheric patterns and winter precipitation over north‐western South Asia
Authors: Dar Junaid , Dar Abdul Qayoom , Nayak Munir Ahmad 
Published: May 2023

AbstractMid‐latitude storms act as crucial atmospheric bridges between global teleconnection patterns and regional precipitation distribution during boreal winter over South Asia. In this work, we study the spatio‐temporal variability of seasonal precipitation over South Asia over the last four decades, which reveals distinct regional precipitation patterns across seasons. For the winter region of South Asia (WRSA), the second Empirical orthogonal function (EOF2) of 500 hPa geopotential heights shows a significant positive correlation with precipitation. Furthermore, using regression analysis, we estimate that the first six EOFs explain most of the interannual variability in winter precipitation during the positive phase of AMO. The results show that six standard climate indices influence winter precipitation over WRSA. We observed a decadal variability in the relationship between ENSO and winter precipitation over WRSA that is modulated by Pacific Decadal Oscillation (PDO) and Atlantic Multidecadal Oscillation (AMO). The positive phase of AMO strengthens the positive relationship between ENSO and winter precipitation over WRSA. The model results also show that two other oscialltions, DMI and AAO, significantly explain the variability of winter precipitation over WRSA. The atmospheric patterns extracted in this study significantly improve winter precipitation forecasting skill of linear regression models compared to those based on standard climate indices, especially during positive AMO winters. The results from this study can be used to improve seasonal predictability of winter precipitation over WRSA.
Study on the phenolic composition and antioxidant properties of white‑, yellow‑, and black‐corn (Zea mays L.) foodstuffs
Authors: Blanch Gracia Patricia , de Pascual‐Teresa Sonia , Ruiz del Castillo María Luisa 
Published: May 2023

AbstractBACKGROUNDBlack corn possesses potent antioxidants, but these are mostly lost during processing. In this study we evaluated the antioxidant content of two different black (‘Millo Corvo’) corn‐based products (i.e. tortillas and cookies) subject to moderate processing. A parallel study on white and yellow corns was carried out for comparison.RESULTSRaw ‘Millo Corvo’ flour exhibited higher contents of phenolic acids, flavonoids, and particularly anthocyanins than white and yellow flours did. Phenolic acids decreased in cookies but did not in tortillas; flavonoids did not exhibit a clear tendency, and anthocyanins were always preserved. Antioxidant activity (AA) obtained for ‘Millo Corvo’ samples was twice as high as the value measured in white and yellow corns in terms of 1,1‐diphenyl‐2‐picrylhydrazyl radical scavenging activity. The difference in AA was even more remarkable in terms of photochemiluminiscence antiradical activity. The conditions used during the cookie‐making process enabled the natural antioxidant characteristics of ‘Millo Corvo’ to be preserved. However, the conditions applied to prepare tortillas resulted in major losses.CONCLUSIONSThe initial phenolics, in particular anthocyanins, and AA of ‘Millo Corvo’ flour can be maintained during processing as long as the conditions applied are 183 °C for 20 min in the absence of a high water content. Millo corvo products possess improved antioxidant characteristics compared with those from white and yellow corns. Millo corvo is a promising black corn type to prepare health‐promoting corn‐based foodstuffs. © 2023 Society of Chemical Industry.
Slipped capital femoral epiphyses: A major on‐target adverse event associated with FGFR tyrosine kinase inhibitors in pediatric patients
Authors: Farouk Sait Sameer , Fischer Cheryl , Antal Zoltan , Spatz Krisoula , Prince Daniel E. , Ibanez Katarzyna , Behr Gerald G. , Dunkel Ira J. , Karajannis Matthias A. 
Published: May 2023

AbstractFibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors (TKIs) are increasingly being used off label in pediatrics. Long‐term safety data are limited, and serious toxicities unique to pediatrics may emerge. In a retrospective analysis of patients less than 18 years of age with recurrent/refractory FGFR altered gliomas treated with FGFR TKIs at MSKCC (n = 7), we observed slipped capital femoral epiphyses in three of seven patients along with increased linear growth velocity. Clinicians should closely monitor bone health and have a low index of suspicion for serious orthopedic complications including slipped capital femoral epiphyses and inform patients of related risks as part of consent when treating with FGFR TKIs.
Introduction to the COG Diagnostic Imaging Committee/SPR Oncology Committee White Papers: Rationale and methods
Authors: Tang Elizabeth R. , Alazraki Adina L. , Thacker Paul G. , McCarville M. Beth , Towbin Alexander J. 
Published: May 2023

AbstractPediatric cancer is a rare disease. Because of this, many sites do not have experience providing imaging for specific tumor types. The Children's Oncology Group Diagnostic Imaging Committee and the Society for Pediatric Radiology Oncology Committee are comprised of radiologists with expertise in pediatric cancer imaging. Recently, this group endeavored to create a series of 23 White Papers designed to provide evidence‐based imaging recommendations and minimum achievable imaging protocols. The purpose of this manuscript is to describe the methods employed in authoring the White Paper series.
X‐linked pyruvate dehydrogenase complex deficiency due to a novel PDHA1 variant associated with structural brain abnormalities in a fetus
Authors: Tanner Laura M. , Tynninen Olli , Piippo Kirsi , Puhakka Antti M. 
Published: May 2023

AbstractWe report a case of pyruvate dehydrogenase E1 alpha subunit deficiency associated with a novel hemizygous PDHA1 variant presenting prenatally as multiple structural brain abnormalities in a male fetus. A healthy Finnish couple was initially referred to the Fetomaternal Medical Center because of suspected fetal choroid plexus cyst at 11 + 2 weeks of pregnancy. At 20 + 0 weeks, multiple abnormalities were observed with ultrasound including narrow thorax, slightly enlarged heart, hypoplastic cerebellum, absent cerebellar vermis and ventriculomegaly. Autopsy and genetic analyses were performed after the termination of pregnancy. The findings of macroscopic examination included cleft palate, abnormally overlapping position of fingers and toes and dysmorphic facial features. Neuropathological examination confirmed the absence of corpus callosum, cerebellar hypoplasia and ventriculomegaly. Nodular neuronal heterotopia was also observed. Trio exome sequencing revealed a novel hemizygous de novo variant c.1144C>T p.(Gln382*) in the PDHA1 gene, classified as likely pathogenic. We suggest that inherited metabolic disorders should be kept in mind as differential diagnoses in fetuses with structural brain abnormalities.
The grading of stomach position for postnatal outcomes in isolated left‐sided congenital diaphragmatic hernia: A systematic review and meta‐analysis
Authors: Hou Chenxiao , Wang Jingjing , Song Shijing , Wu Qingqing 
Published: May 2023

AbstractObjectivesTo evaluate the correlation between stomach position (SP) grading and postnatal outcomes in fetuses with isolated left‐sided congenital diaphragmatic hernias (CDHs).MethodsA literature search was conducted using the PubMed, Embase, and Cochrane Library databases. The corresponding 95% confidence intervals (CIs) were used to assess the differences in the odds of mortality according to the SP graded as level 0 to level 3. To evaluate the reliability of our results, a sensitivity analysis was also conducted.ResultsNine papers with a total of 542 fetuses with isolated left‐sided CDH were included. Congenital diaphragmatic hernia pregnancies complicated by an intrathoracic stomach had higher odds of neonatal mortality when compared with intraabdominal stomach (odds ratio [OR] 2.86; 95% CI 1.38–5.94). Four papers with SP grading from level 0 to level 3 were included in a subgroup analysis. Stomach position at level 1 and level 2 had lower odds of neonatal mortality when separately compared to level 3 (OR 0.12; 95% CI 0.04–0.33) and (OR 0.30; 95% CI 0.16–0.54). Stomach position at level 1 had lower odds of neonatal mortality when compared with level 2 + 3 (OR 0.25; 95% CI 0.09–0.66).ConclusionSurvival of fetuses with isolated left‐sided CDH is correlated with the SP.