bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age‐specific differences in hypertension combination management and associated factors influencing treatment choice
Authors: Xiong Jianfei , Wang Li , Yang Chuanxi , Huang Hengye , He Ben , Shen Lan , Su Feng 
Published: May 2023

AbstractThe current hypertension guideline emphasizes combination therapy, especially single‐pill combination therapy (SPC). However, few studies compared the prevalence and factors associated with initial therapy choice across heterogeneous age groups in a current population. First, the authors consecutively identified 964 treatment naïve hypertensive patients in a large academic hospital from 01/31/2019 to 01/31/2020. All patients were grouped into (1) young aged, age < 55; (2) middle‐aged, 55≤age < 65; and (3) older aged, age ≥65. The multivariable regression model examined the factors associated with the combination therapy by age group. Overall, 80 (8.3%) were young, 191 (19.8%) were middle, and 693 (71.9%) were older aged. Compared with older age, younger patients were more likely to be male, highly educated, regularly exercised, have metabolic syndrome, and less likely to have cardiovascular‐related comorbidities, with a lower systolic but higher diastolic pressure. Only one in five patients used SPC, and the prevalence decreased with age. Besides hypertension grade, young patients without catheterization or echo test were less likely to receive multiple therapies, while older patients who were male with lower weight and lower risk levels were less likely to receive multiple therapies. In conclusion, combination therapy, especially SPC, was underused in the targeted hypertensive population. Our contemporary population study showed that young patients (<55) without a history of catheterization or echo examination and male older‐aged (≥65) patients with low‐risk classification were the population most likely to be neglected. Such information can help triage medical care resources in improving SPC use.
A data‐analytic framework to monitor product density of four‐effect falling‐film evaporator for skimmed milk production
Authors: Wagh Nivedita , Agashe Sudhir D. 
Published: May 2023

AbstractThe implementation of Industry 4.0 needs the convergence in operational technology and information technology (OT–IT) for improving the flexibility to access real‐time data and KPIs. In India, a small‐scale automation industry is full of edge devices and produces massive amount of data due to which an infrastructure may overwhelm. These industries face challenges in convergence of IT–OT like scalability. This work developed a data‐driven framework, which is an additional infrastructure between the IT–OT platforms. The framework consists of data cleaning which helps to remove the anomaly from the sensor data. The uncertainty analysis ensures the correctness of the data. Variable ranking and correlation matrix help to identify the KPIs of the process. All these stages are helpful to select the data and push this selected data to cloud for developing predictive or diagnostic models. This framework is deployed for the performance prediction of four‐effect falling‐film evaporator used to produce skimmed milk. The outlet skimmed milk density is the key performance indicator for the present case study and it is monitored here. Both linear and neural network‐based nonlinear models are used in the framework. It is noticed that linear regression model is capable of predicting the plant product density of skimmed milk with good accuracy. However, it is not capable to identify the faults in the key parameters like inlet milk flow rate. These faults can be better identified using k‐means clustering at the initial stage of the framework.Practical applicationsThis article titled “A data‐analytic framework to monitor product density of four‐effect falling‐film evaporator for skimmed milk production” by Nivedita Wagh and Sudhir D. Agashe contains the results obtained for data‐driven framework for performance prediction and fault diagnosis for four‐effect falling‐film evaporator used for production of skimmed milk. A data‐driven framework which includes uncertainty analysis, variable ranking, various linear and neural network‐based nonlinear regression models for performance prediction, and fault detection of an evaporator is proposed. The results are presented in terms of density of the skimmed milk as a performance parameter. The objective of the work is to provide the possibility of IT–OT convergence so as to solve the scalability issue in the IT–OT convergence. The authors are able to bring out a data‐driven framework for fault identification using k‐means clustering using four‐effect falling‐film evaporator used for production of skimmed milk as a case study. We hope the results will be useful to data managers for understanding the KPIs statistics and take appropriate decision in time for the overall growth of organization.
New scoring system combining computed tomography body composition analysis and inflammatory–nutritional indicators to predict postoperative complications in stage II–III colon cancer
Authors: Ma Zheng , Liu Ruiqing , Liu Huasheng , Zheng Longbo , Zheng Xuefeng , Li Yinling , Cui Haoyu , Qin Chen , Hu Jilin 
Published: May 2023

AbstractBackground and AimPostoperative complications are important clinical outcomes for colon cancer patients. This study aimed to investigate the predictive value of inflammatory–nutritional indicators combined with computed tomography body composition on postoperative complications in patients with stage II–III colon cancer.MethodsWe retrospectively collected data from patients with stage II–III colon cancer admitted to our hospital from 2017 to 2021, including 198 patients in the training cohort and 50 patients in the validation cohort. Inflammatory–nutritional indicators and body composition were included in the univariate and multivariate analyses. Binary regression was used to develop a nomogram and evaluate its predictive value.ResultsIn the multivariate analysis, the monocyte–lymphocyte ratio (MLR), systemic immune‐inflammation index (SII), nutritional risk score (NRS), skeletal muscle index (SMI), and visceral fat index (VFI) were independent risk factors for postoperative complications of stage II–III colon cancer. In the training cohort, the area under the receiver operating characteristic curve of the predictive model was 0.825 (95% confidence interval [CI] 0.764–0.886). In the validation cohort, it was 0.901 (95% CI 0.816–0.986). The calibration curve showed that the prediction results were in good agreement with the observational results. Decision curve analysis showed that colon cancer patients could benefit from the predictive model.ConclusionsA nomogram combining MLR, SII, NRS, SMI, and VFI with good accuracy and reliability in predicting postoperative complications in patients with stage II–III colon cancer was established, which can help guide treatment decisions.
Carcinogenic potential in regenerated mucosa after endoscopic resection of esophageal squamous cell carcinoma
Authors: Akizue Naoki , Okimoto Kenichiro , Hirotsu Yosuke , Amemiya Kenji , Kaneko Tatsuya , Ohta Yuki , Taida Takashi , Saito Keiko , Matsumura Tomoaki , Nishimura Motoi , Matsushita Kazuyuki , Mochizuki Hitoshi , Chiba Tetsuhiro , Arai Makoto , Kato Jun , Omata Masao , Kato Naoya 
Published: May 2023

AbstractBackground and AimLittle is known about genetic mutations in the regenerated mucosa (RM) after endoscopic resection (ER) of esophageal carcinoma. Thus, this study investigates the status of genetic variation in RM after ER of esophageal squamous cell carcinoma (ESCC).MethodsThe study cohort included 19 patients with ESCC. We used an esophageal carcinoma panel to identify target sequences for squamous cell carcinoma (SCC), background mucosa (BM), and RM after ER of ESCC. We used OncoKB to check whether each mutation was a putative driver.ResultsWe identified 77 mutations of 32 genes in SCC, 133 mutations of 34 genes in BM, and 100 mutations of 29 genes in RM. Putative driver mutations were identified in 20 mutations in 14 cases in SCC, 16 mutations in 10 cases in BM, and 7 mutations in 11 cases in RM. The rate of putative driver mutations to total mutations was significantly lower in RM (26% in SCC vs 12% in BM vs 7% in RM, P = 0.009). Additionally, the rate of cases with TP53 putative driver mutations was significantly lower in RM (63% in SCC vs 37% in BM vs 16% in RM, P = 0.011). The percentage of putative driver mutations and the percentage of cases with a putative driver of TP53 were significantly lower in RM.ConclusionEsophageal RM after ER of ESCC could have a lower risk of carcinogenesis.
Rethinking the nineteenth‐century museum via the Ottoman imperial museum
Authors: Ünlüönen Sezen 
Published: May 2023

AbstractMost accounts of the Ottoman Imperial Museum view the museum primarily as a Westernization project for the Ottoman Empire. In such readings, the museum follows a teleological trajectory toward the European norm. This article reads several of the early practices of the Ottoman Imperial Museum (such as interactive museum displays and the sultan's casual gifting of museum holdings to other European monarchs), not as hiccups on the way to Westernization, but rather as a distinctly Ottoman vision of museology and imperial power. Seen in this light, the early history of the Ottoman Imperial Museum challenges the standard account of the nineteenth‐century imperial museum as a site where imperial subjects are molded and where the empire displays its might. Instead, in the case of the Ottoman Imperial Museum, the scientific and orderly organization of the museum artifacts become a testament not to imperial power, but to imperial powerlessness.
Developmental Dyslexia and the Stress of Reading: A Social Stress Study of Neuroendocrine Response in Children
Authors: Buchweitz Augusto , de Azeredo Lucas Araújo , Esper Nathalia Bianchini , Dalfovo Nicole Prigol , Picoli Fernanda , da Cunha Fernanda Silva , Viola Thiago Wendt , Grassi‐Oliveira Rodrigo 
Published: May 2023

AbstractDyslexia is a neurodevelopmental disorder characterized by persistently slow and effortful reading. It is associated with core cognitive deficits in decoding words, but it also presents significant challenges associated with, for example, anxiety and stress related to academic performance. We asked, thus, whether, reading out loud would be associated with elevated stress for readers with dyslexia, relative to good readers, and we investigated stress‐related hormone response in these two groups. We carried out an acute psychosocial stress test (Trier Social Stress Test‐Children adapted for children, TSST‐C), which included a reading out loud task. We carried out a quasi‐experimental study with an experimental group of participants with Developmental Dyslexia (n = 17), and a control group, with good readers (n = 18). During the stress test, we collected six saliva samples for evaluation of two stress‐related hormones, cortisol, and adrenocorticotropic hormone (ACTH) levels. We found a main effect for group for ACTH and for cortisol levels. We also found significantly higher levels of ACTH in the dyslexic group at the end of the task, and during the post‐task recovery period. Results are discussed in the light of the less‐understood emotional impact of dyslexia, and of a recently proposed role for stress as a trigger for increased risk of development of dyslexia. Lastly, we underscore the contribution for the evidence of the emotional impact of learning disorders, especially, as is the case, from a population generally underrepresented in cognitive neuroscience research (i.e., Latin‐American children).
Iran and the SCO: The Quest For Legitimacy and Regime Preservation
Authors: Grajewski Nicole Bayat 
Published: May 2023

AbstractAt the 2021 Shanghai Cooperation Organization (SCO) summit, the Russian‐ and Chinese‐led bloc announced the approval of Iran's longstanding bid for membership. Iran has viewed its involvement in the organization as a means of bolstering external legitimacy, fostering security‐oriented regionalism, and promoting the transition toward the so‐called multipolar world order. The SCO has served as a regime‐preservation network by providing Iran with a source of solidarity against external pressure. Tehran's commitment to the normative order, sustained by the SCO's discourse of noninterference, sovereignty, and countering the “three evils”—terrorism, extremism, and separatism—has galvanized the organization's role as a common front against the imposition of liberal norms and challenges to regime security.
Heat shock‐induced enhanced susceptibility of barley to Bipolaris sorokiniana is associated with elevated ROS production and plant defence‐related gene expression
Authors: Künstler A. , Füzék K. , Schwarczinger I. , Nagy J. K. , Bakonyi J. , Fodor J. , Hafez Y. M. , Király L. 
Published: May 2023

Abstract

Heat stress alters plant defence responses to pathogens. Short‐term heat shock promotes infections by biotrophic pathogens. However, little is known about how heat shock affects infection by hemibiotrophic pathogens like Bipolaris sorokiniana (teleomorph: Cochliobolus sativus). We assessed the effect of heat shock in B. sorokiniana‐susceptible barley (Hordeum vulgare cv. Ingrid) by monitoring leaf spot symptoms, B. sorokiniana biomass, ROS and plant defence‐related gene expression following pre‐exposure to heat shock.

For heat shock, barley plants were kept at 49 °C for 20 s. B. sorokiniana biomass was assessed by qPCR, ROS levels determined by histochemical staining, while gene expression was assayed by RT‐qPCR.

Heat shock suppressed defence responses of barley to B. sorokiniana, resulting in more severe necrotic symptoms and increased fungal biomass, as compared to untreated plants. Heat shock‐induced increased susceptibility was accompanied by significant increases in ROS (superoxide, H2O2). Transient expression of plant defence‐related antioxidant genes and a barley programmed cell death inhibitor (HvBI‐1) were induced in response to heat shock. However, heat shock followed by B. sorokiniana infection caused further transient increases in expression of HvSOD and HvBI‐1 correlated with enhanced susceptibility. Expression of the HvPR‐1b gene encoding pathogenesis‐related protein‐1b increased several fold 24 h after B. sorokiniana infection, however, heat shock further increased transcript levels along with enhanced susceptibility.

Heat shock induces enhanced susceptibility of barley to B. sorokiniana, associated with elevated ROS levels and expression of plant defence‐related genes encoding antioxidants, a cell death inhibitor, and PR‐1b. Our results may contribute to elucidating the influence of heat shock on barley defence responses to hemibiotrophic pathogens.
Sparse principal component analysis for high‐dimensional stationary time series
Authors: Fujimori Kou , Goto Yuichi , Liu Yan , Taniguchi Masanobu 
Published: May 2023

AbstractWe consider the sparse principal component analysis for high‐dimensional stationary processes. The standard principal component analysis performs poorly when the dimension of the process is large. We establish oracle inequalities for penalized principal component estimators for the large class of processes including heavy‐tailed time series. The rate of convergence of the estimators is established. We also elucidate the theoretical rate for choosing the tuning parameter in penalized estimators. The performance of the sparse principal component analysis is demonstrated by numerical simulations. The utility of the sparse principal component analysis for time series data is exemplified by the application to average temperature data.
Behavioral extremity moderates the association between certainty in attitudes about COVID and willingness to engage in mitigation‐related behaviors
Authors: Siev Joseph J. , Petty Richard E. , Paredes Borja , Briñol Pablo 
Published: May 2023

AbstractPeople generally intend to act more on beliefs and attitudes about which they have greater certainty. However, we introduce a boundary condition to the positive association between certainty and behavioral intentions—behavioral extremity. Uncertainty about a threatening issue like COVID‐19 can be disconcerting, and we propose that uncertain people cope in part through increased openness to extreme actions like accepting risky medical treatments and aggression toward those defying mitigation policies. Testing this, we compiled and analyzed all the data on certainty about COVID‐19 mitigation policies and willingness to engage in mitigation‐related behaviors that our lab collected during the pandemic (6 samples, 20 behaviors, Ns up to 1496). External ratings of the behaviors' extremity moderated certainty‐willingness associations: whereas greater certainty was associated with increased willingness to engage in moderate behaviors (the typical result), lower certainty was associated with increased willingness to engage in extreme behaviors, especially among those worried about becoming ill.
Clinical characteristics and outcomes in CMV infection in intestinal transplant recipients: A single‐center experience
Authors: Fernandez Anmary A. , Simkins Jacques , Anjan Shweta , Abbo Lilian , Selvaggi Gennaro , Venkatasamy Vighnesh , Miyashiro Rafael , Martin Eric , Turkeltaub Joshua , Arosemena Leopold , O'Brien Christopher , Tekin Akin , Vega Ana , Perez Michelle M. , Kelly Jennifer Jebrock , Garcia Jennifer , Vianna Rodrigo M. , Natori Yoichiro 
Published: May 2023

AbstractBackgroundCytomegalovirus (CMV) infection is one of the most common posttransplantation infections and has been associated with increased rejection and mortality. Data in intestinal transplants recipients are limited.MethodsThis is a single‐center, retrospective cohort study of all intestinal transplants performed between January 1, 2009, and August 31, 2020. We included recipients of all ages who were at risk of CMV infection. To identify the risk factors, we conducted at first univariate and multivariate analysis. For the multivariate analysis, we developed a logistic regression model based on the result of univariate analysis.ResultsNinety five patients with a median age of 32 (interquartile range [IQR] 4, 50) were included. CMV donor seropositive/recipient seronegative were 17 (17.9%). Overall, 22.1% of the recipients developed CMV infection at a median time of 155 (IQR 28–254) days from transplant, including 4 CMV syndrome and 6 CMV end‐organ disease. Overall, 90.4%, (19/21) developed DNAemia while on prophylaxis. Median peak viral load and time to negativity was 16 000 (IQR 1034–43 892) IU/mL and 56 (IQR 49–109) days, respectively. (Val)ganciclovir and foscarnet were utilized in 17 (80.9%) and 1 (4.76%) recipients, respectively. Recurrences of CMV DNAemia and graft rejection were observed in three and six recipients, respectively. Younger age was identified as a risk factor (p = .032, odds ratio 0.97, 95% confidence interval 0.95–0.99) to develop CMV DNAemia.ConclusionA significant proportion of intestinal transplant recipients developed CMV infection while on prophylaxis. Better methods such as CMV cell mediated immunity guided prophylaxis should be used to prevent infections in this population.
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Sickle cell disease and the need for blood: Barriers to donation for African, Caribbean, and Black young adults in Canada
Authors: Haw Jennie , Walrond Jean , Jayachandran John , Dordunoo Dzifa , Eche‐Ameh Hannah , Muwhen Ufuoma , Phiri Princess , Rastogi Jaya , Tinga Biba 
Published: May 2023

AbstractBackgroundMany blood operators around the world face the challenge of increasing the number of donors of African ancestry to meet the transfusion needs of people living with sickle cell disease. This article reports results of the barriers to blood donation for young adults (aged 19–35) in Canada who identify as African, Caribbean, or Black.Study Design and MethodsA community‐based qualitative study was conducted by researchers from community organizations, blood operator, and universities. In‐depth focus groups and interviews (n = 23) were conducted from Dec 2021 to Apr 2022 and thematic analysis was completed.ResultsApplying a socio‐ecological model, multiple levels of interacting barriers to blood donation were identified. These included macro‐level barriers (e.g., systemic racism, mistrust of the healthcare system, sociocultural beliefs and views about blood and sickle cell disease), mezzo‐level barriers (e.g., deferral criteria, minimum hemoglobin levels, donor questionnaire, access, parental concerns), and microlevel barriers (e.g., limited knowledge of blood needs for people with sickle cell disease, lacking information about blood donation process, fear of needles, personal health concerns).DiscussionThis study is the first to focus on barriers to donation for African, Caribbean, and Black young adults across Canada. Parental concerns, informed by parents' experiences of inequitable healthcare and mistrust, emerged as a novel finding in our study population. Results suggest that higher order (macro‐level) barriers influence and may reinforce lower order (mezzo‐ and microlevel) barriers. As such, interventions aimed at addressing barriers to donation should keep in view all levels with particular attention paid to higher order barriers.
Dense lineability and spaceability in certain subsets of ℓ∞$\ell _{\infty }$
Authors: Leonetti Paolo , Russo Tommaso , Somaglia Jacopo 
Published: May 2023

AbstractWe investigate dense lineability and spaceability of subsets of with a prescribed number of accumulation points. We prove that the set of all bounded sequences with exactly countably many accumulation points is densely lineable in , thus complementing a recent result of Papathanasiou who proved the same for the sequences with continuum many accumulation points. We also prove that these sets are spaceable. We then consider the same problems for the set of bounded non‐convergent sequences with a finite number of accumulation points. We prove that such a set is densely lineable in and that it is nevertheless not spaceable. The said problems are also studied in the setting of ideal convergence and in the space .
Distribution of Dirichlet L‐functions
Authors: Dong Zikang , Wang Weijia , Zhang Hao 
Published: May 2023

AbstractIn this article, we study the distribution of values of Dirichlet L‐functions, the distribution of values of the random models for Dirichlet L‐functions, and the discrepancy between these two kinds of distributions. For each question, we consider the cases of and separately.
Meteorological Influence on Space-time Distribution of Tomé-Açu (Eastern Amazon) Vegetation Cover using MODIS Products
Authors: Rua Matheus Lima , Fernandes Gabriel Siqueira Tavares , Dos Santos Anderson , Santana Mateus Augusto De Carvalho , Pantoja Marcos Vinicius Santos , Teixeira Keila Beatriz Silva 
Published: May 2023

The objective of this study was to analyze the seasonal behavior of vegetation cover and its response to the variation of meteorological elements in the microregion of Tomé-Açu, Eastern Amazon. The study area refers to the microregion of Tomé-Açu, Pará. MODIS sensor images were processed and analyzed on Google Earth Engine and QGIS 3.18.1 software to apply the NDVI, EVI and LAI vegetation indices. Results showed that the vegetation cover of the Microregion of Tomé-Açu has well-defined seasonality, with evident variation in vegetation indices throughout the year. The three indexes showed higher values in the dry season period and lower values in the rainy period of the year. Seasonality of vegetation cover showed a positive correlation with rainfall in the region, with higher values associated with rainfall occurring between 4 and 5 months prior to the observation.