bluuebunny/crossref_metadata_2025_split huggingface dataset:
El control de los objetores de conciencia tras la nueva ley de la eutanasia
Authors: Valcárcel García Macarena 
Published: June 2023

With the intention of analyzing the controls on the objects of conscience in the health field, an approximation to the concept of this right to avoid a tender activity that the law requires for reasons of conscience is carried out in the first place, in order to subsequently carry out a review with due depth of the constitutional jurisprudence that has been building, with different course changes in its interpretation, since 1982. The development of the necessary regulations that have supported and protected the exercise of conscientious objection, in the different areas where this has a place in Spain, occupies the next part of the text until reaching the regulations in the specific field of health conscientious objection, making an analysis of its content and its results, especially and due to the existence of sufficient data on the objection to voluntary terminations of pregnancy. Finally, the analysis of the registry of objects established by the Organic Law of Euthanasia, whose development has been transferred to the Autonomous Communities, and the proposal of the possibility of a substitute benefit to the objects of sanitary conscience finalize this article.
Con la intención de analizar los controles sobre los objetores de conciencia en el ámbito sanitario, se realiza en primer lugar una aproximación al concepto de este derecho para evitar una lícita actividad, por motivos de conciencia, a la que la ley obliga a realizar determinas prácticas. Posteriormente se llevará a cabo una revisión con la debida profundidad de la jurisprudencia constitucional que ha venido construyéndose, con distintos cambios de rumbo en su interpretación, desde 1982. El desarrollo de la necesaria normativa que ha amparado y ampara el ejercicio de la objeción de conciencia, en los distintos ámbitos donde esta tiene cabida en España, ocupa siguiente parte del texto hasta llegar a las regulaciones en el ámbito concreto de la objeción de conciencia sanitaria haciendo un análisis de su contenido y de sus resultados, en especial y por la existencia de datos suficientes sobre la objeción a las interrupciones voluntarias del embarazo. Finalmente, el análisis del registro de objetores establecido por la Ley Orgánica de la Eutanasia, cuyo desarrollo se ha trasladado a las Comunidades Autónomas, y la propuesta de la posibilidad de una prestación sustitutoria a los objetores de conciencia sanitarios finalizan este artículo.
Analysis of Quality Cycles on Performance of Tea Processing Firms in Kenya
Authors: Wanjobi George Muturi , Yatich Henry , Ndolo Jackson 
Published: June 2023

Aim of Study: The aim of the study was to assess how quality cycles impact the performance of tea processing companies in Kenya. The research was guided by Deming's quality improvement theory. Pragmatism research philosophy was employed in this research.
Study Design: Further, explanatory research design was deemed appropriate for the research.
Methodology: The study population under consideration was 66 operations managers of all the tea producing companies. A census of all the 66 operations managers was conducted. Utilizing structured questionnaires, both quantitative and qualitative data was gathered for analysis. Data analysis was undertaken utilizing SPSS Version 23.0.
Results: The findings revealed that quality cycles had positive and significant relationship with performance of tea processing firms in Kenya where (β =.335) and p=.011). The study concludes that quality cycles are critically important in the production of tea. Tea processing firms need to cultivate culture of team work among their workers by emphasizing virtues of unity and togetherness. The study recommends for periodic diagnostic and maintenance of firm machines and equipment through well trained firm personnel. Thus, training of personnel on the maintenance of tea production equipment is essentially important in ensuring that costs arising from breakdowns are minimized. Organizational dynamic capability moderates the relationship between Kaizen Systems and performance of tea processing firms. Also, tea processing firms should invest in research and development, training, networking capability and innovation since it affects performance positively.
Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Bilastine and Montelukast in Tablet Dosage Form
Authors: Vallakeerthi Narmada , Swetha Rachala , Tejaswi T. , Nath A. Ravinder , Bhavyasri K. , Reddy N. Naresh , Reddy P. Muralidhar 
Published: June 2023

Place of Study: Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana.
Aim: The present study is describing about the development of a new RP-HPLC method for the simultaneous estimation of Bilastine and Montelukast in Active Pharmaceutical Ingredient (AI) and commercial formulations.
Methodology: In the present investigation, an Inertsil ODS C18 column dimensions of 250 mm length x 4.6 Internal diameter x 5-micron particle size has been chosen. Phosphate buffer and acetonitrile were opted as isocratic mobile phase at a ratio of 30:70, with a flow rate of 1 ml/min. The pH of the developed buffer was maintained at 4.6 and the temperature was set at room temperature. The wavelength of Bilastine and Montelukast was observed at 260 nm. For both Bilastine and Montelukast the retention time has been observed at 2.319 and 4.299 minute correspondingly. The percentage purity of both the drugs was found to be 100.6 % and 100.3 % correspondingly. The developed method satisfied all the system suitability parameters for Bilastine and Montelukast and the observed values for theoretical plates were found to be 1.3 and 1.4 respectively, tailing factor were found to be 5117.5 and 3877.8 respectively with a resolution of 9.0.
Results: Finally, the method was validated by parameters such as precision, accuracy, robustness and ruggedness. The linearity and range were from 1-5µg and 100-500 µg concentrations series, the correlation coefficient for both the drugs was noted to be 0.999 while the mean percentage recovery was observed at 100.1 percent & 100.4 percent. The % RSD for repeatability was found to be 0.31 and 0.38. The % RSD of intermediate precision was found to be 0.12 & 0.15 correspondingly. The LOD values were found as 2.94, 3.03 and for the LOQ values were found as 9.87, 10.1.
Conclusion: The developed method which was validated was observed to be novel, accurate, simple, robust, precise, repeatable for the present study with a suitable RP-HPLC technique to concurrently determine Bilastine and Montelukast present in the commercial formulation. This developed method is useful on daily basis due to their accurate results, reproducibility, robustness for the estimation of samples in routine quality control departments.
Evaluation of Mulching Methods and Legume Intercropping on Weed Control Efficiency and Agronomic Traits of Pearl Millet (Pennisetum glaucum)
Authors: Sharon X. Catherine , Manuel R. Isaac , Sharmili K. , Kumar Dinesh 
Published: June 2023

Aim: To evaluate the weed control efficiencies of different mulching practices and legume intercropping in transplanted pearl millet.
Study Design: Randomized Complete Block Design (RBD).
Place and Duration of Study: The field trial was conducted during the Rabi season of 2022 at the school of agricultural sciences in Karunya Institute of technology and sciences, Coimbatore, Tamil Nadu.
Methodology: The field trial consists of 8 treatments viz., T1 - PE of Atrazine 0.5kg/ ha +1 Hand Weeding at 30 DAT, T2 - Two Hand Weeding at 15 and 30 DAT, T3 - Paddy straw mulching at 5t/ ha 3 DAT, T4 - Black polythene mulching at 3 DAT, T5 - Black silver polythene mulching at 3 DAT, T6 - Intercropping of pulses (cowpea) (1:1), T7 - Intercropping of pulses (cowpea) (1:1) + PE Pendimethalin 0.75 kg/ ha, T8 - Un weeded check.
Results: Results of the experiment proves that the intercropping of cowpea in pearl millet along with the pre-emergence application of pendimethalin proves to be beneficial and advantageous in terms of returns per rupee invested for profitable crop production, rather than going for polythene mulches. Hence adoption of legume intercropping in pearl millet, along with the usage of mild herbicides like pendimethalin, will be an economically viable and environmentally sustainable weed management practice for improving the yield of pearl millet.
Delivery accuracy of VMAT on two beam‐matched linacs provided by accelerated go live service
Authors: Tsuneda Masato , Abe Kota , Fujita Yukio , Morimoto Ryo , Hashimoto Takuma , Abe Yukinao , Uno Takashi 
Published: June 2023

AbstractIntroductionDosimetric accuracy is critical when a patient treated with volumetric modulated arc therapy (VMAT) is transferred to another beam‐matched linac. To evaluate the performance of Accelerated Go Live (AGL) service, the measured beam characteristics and patient specific quality assurance (QA) results between two AGL‐matched linacs were compared.Materials and MethodsTwo VersaHD linacs were installed using the AGL service. After the installation, the beam data such as percentage depth dose (PDD), lateral profiles and output factors for all photon beams were measured. Relative doses were also measured as a function of the multi‐leaf collimator (MLC) leaf gap width. Subsequently, VMAT plans were created for prostate, pelvis, head and neck, liver, lung cancers and multiple brain metastases. Dose distributions and point doses were measured by multi‐dimensional detectors and ionization chambers for patient specific quality assurance, and comparisons were made between the two linacs.ResultsDose differences in PDDs were all within ± 1% except the entrance region, and the averaged gamma indices of the lateral profiles were within 0.3. The differences in doses as a function of the MLC leaf gap width between the two linacs were within ±0.5%. For all the plans, gamma passing rates were all higher than 95% with criteria of 2%/2 mm. The average and the SD of dose differences on the multi‐dimensional detector between both measurements was 0.06 ± 2.12%, and the average of point dose differences was −0.03 ± 0.33%.ConclusionWe have evaluated the AGL performance in the context of beam characteristics and patient specific QA. It was demonstrated that the AGL service provides an accurate VMAT treatment reproducibility for many tumor sites with gamma pass rates greater than 95% under criteria of 2%/2 mm.
A Roadmap Review of Thermally Conductive Polymer Composites: Critical Factors, Progress, and Prospects
Authors: Wang Zhengfang , Wu Zijian , Weng Ling , Ge Shengbo , Jiang Dawei , Huang Mina , Mulvihill Daniel M. , Chen Qingguo , Guo Zhanhu , Jazzar Abdullatif , He Ximin , Zhang Xuehua , Xu Ben Bin 
Published: June 2023

AbstractRecently, the need for miniaturization and high integration have steered a strong technical wave in developing (micro‐)electronic devices. However, excessive amounts of heat may be generated during operation/charging, severely affecting device performance and leading to life/property loss. Benefiting from their low density, easy processing and low manufacturing cost, thermally conductive polymer composites have become a research hotspot to mitigate the disadvantage of excessive heat, with potential applications in 5G communication, electronic packaging and energy transmission. By far, the reported thermal conductivity coefficient (λ) of thermally conductive polymer composite is far from expectation. Deeper understanding of heat transfer mechanism is desired for developing next generation thermally conductive composites. This review holistically scopes current advances in this field, while giving special attention to critical factors that affect thermal conductivity in polymer composites as well as the thermal conduction mechanisms on how to enhance the λ value. This review covers critical factors such as interfacial thermal resistance, chain structure of polymer, intrinsic λ value of different thermally conductive fillers, orientation/configuration of nanoparticles, 3D interconnected networks, processing technology, etc. The applications of thermally conductive polymer composites in electronic devices are summarized. The existing problems are also discussed, new challenges and opportunities are prospected.
Direct Visualization of Chemically Resolved Multilayered Domains in Mixed‐Linker Metal–Organic Frameworks
Authors: Centrone Andrea , Lerma‐Berlanga Belen , Biacchi Adam J. , Fernández‐Conde Carmen , Pavlidis Georges , Marti‐Gastaldo Carlos 
Published: June 2023

AbstractThe modular synthesis approach for assembling inorganic nodes and organic multidentate linkers into reticular solids enables rational engineering in porous materials known as metal–organic frameworks (MOFs). Incorporation of two or more linker types in MOF crystals holds great potential for engineering complex pore functionalities, by virtue of chemically heterogeneous domains. However, deciphering linkers distributions in MOFs crystals is challenging because of the insufficient spatial resolution of conventional, chemically sensitive techniques hinders the verification of rational design. Herein, the high spatial resolution and chemical specificity of infrared nanoscopy is leveraged in combination with high‐throughput diffraction‐limited hyperspectral photoluminescence imaging to determine the composition of individual multivariate UiO‐68 MOF crystals (UiO, Universitetet‐i‐Oslo), after linker‐exchange with optically active tetrazine units. The results reveal that the crystals display a three‐layer onion‐like structure composed of a core‐rich in the parent linker, an intermediate multivariate layer with a gradient in linker composition and a proto‐MOF external shell. In this outer layer, a fraction of the linkers’ binding groups is hydrogen bonded rather than coordinated with metal nodes, suggestive of superficial reconstruction during the linker‐exchange. This study advances the analytical capabilities for studying and engineering heterogeneous domains in mixed‐linker MOF crystals down to the nanoscale.
Panthenol Citrate Biomaterials Accelerate Wound Healing and Restore Tissue Integrity
Authors: Wang Huifeng , Duan Chongwen , Keate Rebecca L. , Ameer Guillermo A. 
Published: June 2023

AbstractImpaired wound healing is a common complication for diabetic patients and effective diabetic wound management remains a clinical challenge. Furthermore, a significant problem that contributes to patient morbidity is the suboptimal quality of healed skin, which often leads to reoccurring chronic skin wounds. Herein, a novel compound and biomaterial building block, panthenol citrate (PC), is developed. It has interesting fluorescence and absorbance properties, and it is shown that PC can be used in soluble form as a wash solution and as a hydrogel dressing to address impaired wound healing in diabetes. PC exhibits antioxidant, antibacterial, anti‐inflammatory, and pro‐angiogenic properties, and promotes keratinocyte and dermal fibroblast migration and proliferation. When applied in a splinted excisional wound diabetic rodent model, PC improves re‐epithelialization, granulation tissue formation, and neovascularization. It also reduces inflammation and oxidative stress in the wound environment. Most importantly, it improves the regenerated tissue quality with enhanced mechanical strength and electrical properties. Therefore, PC could potentially improve wound care management for diabetic patients and play a beneficial role in other tissue regeneration applications.
3D‐Printed Patient‐Specific Circles of Willis with an Intracranial Aneurysm and their Application to Neurointerventional Endovascular Simulation
Authors: Kim Yeonwoo , Yang Hyeondong , Cho Kwang‐Chun , Kim Jung‐Jae , Kim Yong Bae , Oh Je Hoon 
Published: June 2023

AbstractCerebrovascular replicas are effective platforms that can simulate endovascular interventions in the treatment of intracranial aneurysm (IA), and an IA typically forms in the tortuously structured cerebral artery circulation known as the circle of Willis (CoW). Effective and reliable endovascular procedure simulation before actual clinical treatment is greatly helpful for neurosurgeons, but the simulation performance depends on how identical a CoW replica is to a patient's CoW. Herein, a tubular, transparent, and patient‐specific CoW replica is fabricated with realistic dimensions and elasticity using a combination of 3D printing and dip coating technique. First, a real‐scale CoW core substrate is constructed using an extrusion‐based 3D printing technology, then the thickness of the vascular wall is manipulated by coating the core substrate layer by layer, and finally the core substrate is dissolved to produce a tubular CoW structure. A liquid‐assisted dip coating method is utilized and optimized for uniform and high‐quality coating layers on the tortuous CoW core substrate. Moreover, the effectiveness of the CoW replica is demonstrated through an in‐house neurointerventional endovascular simulator. The proposed method paves a new way for practical and reliable endovascular simulations, which would help significantly improve the clinical outcomes of current IA treatments.
Structural Design of Oleogel‐Hydrogel Bigels for Co‐Delivery of Curcumin and Epigallocatechin Gallate with Synergistic Stability and Bioactivity
Authors: Yang Jingyi , Fu Yuhan , Zheng Hongxia , Jia Yan , Gao Yanxiang , Yin Shutao , Mao Like 
Published: June 2023

AbstractBigels are novel biphasic systems containing hydrogel and oleogel structures, which are designed to deliver multiple bioactives for synergistic activity. The current study develops bigels based on a carrageenan hydrogel and a monoglyceride (GMS) oleogel. Results show that the microstructures of bigels are facilely modified by two surface active ingredients (Tween 20 and polyglycerol polyricinoleate), which then influence the microstructures of the bigels. When curcumin and epigallocatechin gallate (EGCG) are delivered simultaneously, the bioactives work synergistically to slow thermal degradation. Simulated digestion tests indicate that the bigel structures can delay the release of the two bioactives in artificial saliva and simulated gastric fluid (SGF), and allow fast release in simulated intestinal fluid (SIF). DPPH and ABTS tests show the digested Tween 20 bigels containing EGCG and curcumin present synergistic antioxidant activity. Anticancer activity is evaluated in human colon adenocarcinoma HCT116, and the two bioactives work cooperatively to lower cell viability. The bioactives released from Tween 20 bigels have higher cytotoxicity than those from polyglycerol polyricinoleate bigels. The results reveal that facile structural design of bigels has the potential to achieve synergistic stability and bioactivity of co‐delivered bioactives, which is meaningful for the development of functional pharmaceutical, cosmetic, and food products.
Triplet–Triplet Annihilation Enhanced Deep‐Blue Organic Light‐Emitting Diodes by Naphtho[1,2‐d]imidazole‐Isomer Derivatives with Spin–Orbit Coupling
Authors: Yang Guo‐Xi , Liu Deng‐Hui , Gu Qing , Peng Xiaomei , Li De‐Li , Li Mengke , Liu Ming , Chen Jie , Liu Kunkun , Su Shi‐Jian 
Published: June 2023

AbstractThe utilization of triplet excitons is of great importance for organic light‐emitting diodes (OLEDs). Triplet–triplet annihilation (TTA) is one of the effective tactics to achieve high efficiency deep‐blue organic electroluminescence emitters by converting two triplet excitons into one singlet exciton. Whereas, in addition to the 25% electrogenerated singlet excitons, the proportion of radiative singlet excitons (RSE) produced by the TTA process is usually only 15%; thus the total radiative excitons are 40%. In this study, ≈35% of RSE is achieved by the TTA process (total 60%) with two deep‐blue emitters based on the isomeric naphthoimidazole (NI) unit and anthracene bridge. As a result, non‐doped OLEDs based on the two NI derivatives as emitting layers achieve maximum external quantum efficiencies of 10.9% and 11.2% with an identical deep‐blue emission peak of 452 nm, which are the best TTA OLEDs with a Commission Internationale de l'Eclairage chromaticity Y coordinate below 0.15. Theoretical and experimental results demonstrate that the TTA process can be improved owing to the efficient spin–orbit interactions, even though the energy levels of the triplet pairs are higher than the calculated second triplet excited states.
Diastereo‐ and Enantioselective Organocatalytic Synthesis of Spirocyclopropyl Pyrazolones
Authors: Carceller‐Ferrer Laura , Blay Gonzalo , Muñoz M. Carmen , Pedro José R. , Vila Carlos 
Published: June 2023

AbstractA diastereo‐ and enantioselective synthesis of spirocyclopropylpyrazolones has been described through a Michael/alkylation cascade reaction of 4‐arylidenepyrazol‐5‐ones with diethyl 2‐bromomalonate catalyzed by (DHQ)2AQN. The reaction afforded selectively the corresponding spirocyclic compounds with 30–83% yield, diastereoselectivities ranging from 60:40 to >95:5 and 26–93% enantiomeric excess under mild reaction conditions. Moreover, we performed two selective transformations with the corresponding chiral compounds.
Shifts in flowering phenology in response to spring temperatures in eastern Tennessee
Authors: Faidiga Alexandra S. , Oliver Margaret G. , Budke Jessica M. , Kalisz Susan 
Published: June 2023

AbstractPremisePlant phenological shifts are among the clearest indicators of the effects of climate change. In North America, numerous studies in the northeastern United States have demonstrated earlier spring flowering compared to historical records. However, few studies have examined phenological shifts in the southeastern United States, a highly biodiverse region of North America characterized by dramatic variations in abiotic conditions over small geographic areas.MethodsWe examined 1000+ digitized herbarium records along with location‐specific temperature data to analyze phenological shifts of 14 spring‐flowering species in two adjacent ecoregions in eastern Tennessee.ResultsSpring‐flowering plant communities in the Blue Ridge and the Ridge and Valley ecoregions differed in their sensitivity to temperature; plants in the Ridge and Valley flower 0.73 days earlier/°C on average compared to 1.09 days/°C for plants in the Blue Ridge. Additionally, for the majority of species in both ecoregions, flowering is sensitive to spring temperature; i.e., in warmer years, most species flowered earlier. Despite this sensitivity, we did not find support for community‐level shifts in flowering within eastern Tennessee in recent decades, likely because increases in annual temperature in the southeast are driven primarily by warming summer (rather than spring) temperatures.ConclusionsThese results highlight the importance of including ecoregion as a predictor in phenological models for capturing variation in sensitivity among populations and suggest that even small shifts in temperature can have dramatic effects on phenology in response to climate in the southeastern United States.