bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemberian Topikal ASI Terhadap Resiko Infeksi Tali Pusat Neonatus: Studi Kasus
Authors: Perwiraningtyas Pertiwi , Cahyaningrum Ika , Leton Elisabet Masan 
Published: January 2025

Inflammation of the umbilical cord is one of the triggers of morbidity and mortality in newborns worldwide. Various preventive and curative efforts are made to reduce this incident. This case study aims to improve the provision of nursing care for newborns with infection risk problems. A case study design was used in this study. The research subjects were selected using the accidental sampling method. The study was conducted on three neonates aged 7 days with the condition that the umbilical cord had not yet come off in the postpartum room of Dr. R. Soedarsono Pasuruan Hospital on February 23-28, 2022. The focus of the problem was the risk of infection. The intervention carried out on the umbilical cord using breast milk. The results of the study showed that the umbilical cords of all babies were wet on the first day. The application was by applying the base of the umbilical cord with a cotton bud that had been given 1-2 drops of breast milk, done 2 times in the morning and evening after bathing. After two days of treatment, the nursing problem of infection risk was resolved. This was indicated by the umbilical cord which tended to be dry and there were no signs of inflammation such as: no redness, odor, pus, edema, and tenderness. The results of this case study serve as a guideline for providing nursing care for newborns, especially those at risk of experiencing inflammation of the umbilical cord. Peradangan yang terjadi pada tali pusat menjadi salah satu pencetus morbiditas dan mortalitas bayi baru lahir di seluruh dunia. Berbagai upaya preventif maupun kuratif dilakukan untuk menekan kejadian tersebut. Studi kasus ini bertujuan sebagai upaya peningkatan pemberian asuhan keperawatan pada bayi baru lahir dengan masalah resiko infeksi. Desain studi kasus digunakan dalam penelitian ini. Subjek penelitian dilakukan dengan metode accidental sampling. Penelitian dilakukan terhadap tiga neonatus usia 7 hari dengan kondisi tali pusat belum terlepas di di ruang nifas RSUD dr. R. Soedarsono Pasuruan tanggal 23-28 Februari 2022. Fokus permasalahan adalah resiko infeksi. Intervensi yang dilakukan pada tali pusat dengan menggunakan ASI. Hasil penelitian menunjukkan tali pusat seluruh bayi dalam keadaan basah pada hari pertama. Penerapannya dengan mengoleskan pangkal tali pusat dengan cotton bud yang sudah diberi tetesan ASI sebanyak 1-2 tetes, dilakukan 2 kali pagi dan sore setelah mandi. Setelah perawatan selama dua hari, masalah keperawatan resiko infeksi teratasi. Hal ini ditandai dengan tali pusat yang cenderung kering dan tidak ada tanda-tanda peradangan seperti: tidak ada kemerahan, berbau, pus edema dan nyeri tekan. Hasil studi kasus ini, menjadi salah satu pedoman dalam pemberian asuhan keperawatan bayi baru lahir khususnya yang beresiko mengalami peradangan pada tali pusat
Pengaruh Pendidikan Kesehatan Dengan Media Booklet Terhadap Kecemasan
Authors: Dian Dian_therezah_yadi , Suzanna  , Ayu Dekawaty  
Published: January 2025

Kecemasan merupakan suatu keadaan dimana seseorang merasakan ketidaknyaman disertai bayang-bayang ketakutan, keterasingan, disertai rasa tidak aman. Kondisi ketakutan dan ketidakpastian bisa menyampaikan respon akan suatu keadaan dimana seseorang bisa memprediksi suatu keadaan yang mengancam sehingga seseorang bisa mempersiapakan diri untuk menghadapi keadaan tersebut. Tujuan penelitian ini untuk mengetahui pengaruh pendidikan kesehatan menggunakan media booklet terhadap kecemasan klien di Rumah Singgah Muratara Palembang. Desain penelitian pada penelitian ini Pre-Eksperimental Pretest-Post Test Only One Group Design dengan sampel sebanyak 35 responden. Hasil Dari penelitian ditemukan bahwa pendidikan kesehatan dengan menggunakan media “booklet” memiliki pengaruh terhadap kecemasan terhadap pasien di Rumah Singgah Muratara Palembang dengan nilai 0.00. Dengan nilai rata-rata tingkat kecemasan klien sebelum diberikan pendidikan kesehatan dengan media booklet sebesar 31,943. Dan nilai rata-rata tingkat kecemasan klien setelah diberikan pendidikan kesehatan dengan media booklet sebesar 23,029. Dapat di simpulkan bahwa ada penurunan terhadap tingkat kecemasan sebelum diberikan pendidikan kesehatan menggunakan media Booklet dengan setelah diberikan pendidikan kesehatan menggunakan media Booklet diambil dari nilai p value sebesar 0,000.
BULLYING PREVENTION EDUCATION FOR STUDENTS OF STATE ELEMENTARY SCHOOL 01 BODAS VILLAGE, WATUKUMPUL DISTRICT
Authors: Hilma Zakia  , Ahmad Andi Riyanto  , Mutia Rahmi Maulina  , Nuri Aji Annisa , Wardah Roikha , Lizza Alwiyana Maulida , Misyam Noviana , Rasyid Ghani Muhammad , Sulistiawati Erni , Anis Naila , Rokhimah Hesti , Bahri Samsul , Hermawan Adinugraha Hendri 
Published: January 2025

Bullying merupakan tindakan kekerasan yang dilakukan secara sengaja oleh seseorang, tindakan tersebut dapat mengakibatkan ketidakseimbangan kekuasaan sehingga dapat menjadikan korban bullying merasa trauma. Tindakan ini dapat dilakukan secara individu maupun kelompok. Bullying tidak hanya terjadi di kalangan anak-anak yang masih duduk dibangku sekolah saja, namun juga dapat terjadi pada orang dewasa. Akan tetapi tindakan bullying biasanya terjadi pada anak-anak yang masih sekolah dan sering terjadi di lingkungan sekolah. Oleh karena itu, untuk mencegah terjadinya tindakan bullying maka perlu adanya sosialisasi pada anak-anak mengenai stop bullying. Dalam kegiatan sosialisasi membahas mengenai pengertian bullying, jenis-jenis bullying dampak bullying, tanda-tanda bullying, dan cara mencegah terjadinya bullying. Kemudian diakhir kegiatan sosialisasi melakukan kegiatan fun games dengan mengecap telapak tangan dengan cat lalu ditempelkan ke tempat yang sudah disediakan.
Olfactory impairment in Italian patients with chronic rhinosinusitis with nasal polyps: a patient-centered survey
Authors: Anastasi Francesca , Canevari Frank Rikki Mauritz , Gallo Stefania , Gramellini Giulia , Heffler Enrico , La Mantia Ignazio , Monti Giulia , Ragusa Martina , Macchi Alberto 
Published: January 2025

BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition characterized by persistent nasal obstruction, discharge, facial pressure, and olfactory dysfunction. CRSwNP significantly impairs quality of life (QoL), with olfactory loss being a particularly distressing symptom that affects food enjoyment, personal safety, and social interactions.MethodsThis study investigated the experiences of Italian patients with CRSwNP. A cross-sectional quantitative and qualitative survey (Google Forms questionnaire), collecting data on diagnosis, symptomatology, QoL impact, and treatment experiences was developed and distributed.ResultsThere were 155 respondents, with over half diagnosed with CRSwNP for more than a decade. Nasal obstruction was the primary symptom leading to medical consultation. Corticosteroid therapy and surgery showed limited and variable effectiveness in olfactory restoration. Biologic therapy, particularly dupilumab, demonstrated promising results, with approximately half of the patients reporting complete smell restoration.ConclusionsCRSwNP significantly affected patients' QoL, with olfactory dysfunction being a common and impactful symptom. While current treatments provide symptom relief, they do not always result in sustained olfactory improvement. Biologic therapy emerged as a promising option for olfactory restoration, underscoring the importance of personalized treatment strategies. Further research is warranted to explore the mechanisms of olfactory recovery and to optimize treatment protocols for CRSwNP.
Quantitative relationships between elastic modulus of rod and biomechanical properties of transforaminal lumbar interbody fusion: a finite element analysis
Authors: Li Jie , Du Zengfeng , Cao Shuai , Lu Teng , Sun Zhongwei , Wei Hongyu , Li Haopeng , Zhang Ting 
Published: January 2025

BackgroundCurrently, some novel rods with lower elastic modulus have the potential as alternatives to traditional titanium alloy rods in lumbar fusion. However, how the elastic modulus of the rod (rod-E) influences the biomechanical performance of lumbar interbody fusion remains unclear. This study aimed to explore the quantitative relationships between rod-E and the biomechanical performance of transforaminal lumbar interbody fusion (TLIF).MethodsThe intact finite element model of L1-S1 was constructed and validated. Then 12 TLIF models with rods of different elastic moduli (ranging from 1 GPa to 110 GPa with an interval of 10 GPa) were developed. The range of motion (ROM) of the fixed segment, mean strain of the bone graft, and maximum von Mises stresses on the cage, endplate, and posterior fixation system models were calculated. Finally, regression analysis was performed to establish functional relationships between rod-E and these indexes.ResultsIncreasing rod-E decreased ROM of the fixed segment, mean strain of the bone grafts, and peak stresses on the cage and endplate, while increasing peak stress on the screw-rod system. When rod-E increased from 1 GPa to 10 GPa, ROM decreased by 10.4%–39.4%. Further increasing rod-E from 10 GPa to 110 GPa resulted in a 9.3%–17.4% reduction in ROM. The peak stresses on the posterior fixation system showed a nonlinear increase as the rod-E increased from 1 GPa to 110 GPa under most loading conditions. The R2 values for all fitting curves ranged from 0.76 to 1.00.ConclusionThe functional relationships between rod-E and the biomechanical properties of TLIF were constructed comprehensively. When the rod-E exceeds 10 GPa, further increases may not significantly improve stability, however, it may increase the risk of fixation failure. Therefore, a rod with an elastic modulus of approximately 10 GPa may provide optimal biomechanical properties for TLIF.
Polydatin retards the progression of osteoarthritis by maintaining bone metabolicbalance and inhibiting macrophage polarization
Authors: Sun Qi , Nan Xin-Yu , Wang Hui , Pan Shuo , Ji Gang , Guo Ya-Feng , Zhao Ya-Heng , Li Gao-Cen , Guo Shao-Shi , Lin Lu-Feng , Jin Yu-Jie , Zhang Xue Li , Liu Chang-Cheng , Liu Guo-Bin 
Published: January 2025

BackgroundPolydatin (PD), also known as tiger cane glycoside, is a natural compound extracted from the Japanese knotweed plant, which is often referred to as white resveratrol. It exhibits anti-inflammatory, antioxidant, and anti-apoptotic effects in the treatment of various diseases. However, the potential molecular mechanisms of PD in osteoarthritis have not been clearly elucidated.MethodsAnterior cruciate ligament transection (ACLT) surgery was performed to establish an osteoarthritis animal model. Female mice at the age of 12 weeks were intraperitoneally injected with different concentrations of PD (20 and 40 mg/kg). In vitro models were established by isolating mouse articular chondrocytes, which were subsequently treated with lipopolysaccharide or IL-1β for 24 h for subsequent experiments. In addition, different concentrations of PD were administered for 12 h. Morphological changes were observed by toluidine blue staining, joint bone metabolism changes were observed by tartrate-resistant acid phosphatase staining, immunohistochemistry was used to observe the expression levels of inflammatory factors and extracellular matrix. MicroCT analysis was conducted to assess changes in the microstructure of subchondral bone trabeculae, and Western blot was performed to measure the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway and markers of M1 polarization in macrophages.ResultsPD significantly delays the progression of osteoarthritis induced by ACLT, effectively inhibits IL-1β-induced joint inflammation, bone metabolic remodeling and extracellular matrix degradation. In addition, paeoniflorin markedly suppresses the transmission of the NF-κB signaling pathway and reverses M1 polarization in macrophages induced by IL-1β.ConclusionTaken together, PD might be a potential therapeutic agent for the prevention and treatment of osteoarthritis.
Application of blockchain technology in digital music copyright management: a case study of VNT chain platform
Authors: Shi Qilong , Zhou Yan 
Published: January 2025

IntroductionThis paper presents the design and development of a digital music copyright management system, built on the VNT Chain blockchain platform. The system aims to enhance copyright proof and evidence storage, verify the originality of music copyrights, and facilitate secure copyright transactions.MethodsThe system leverages blockchain technology for data integrity and immutability, utilizes the Shazam algorithm to verify music originality, and employs smart contracts to secure transactions. It is composed of six functional modules: user management, copyright registration, copyright trading, infringement monitoring, evidence storage, and music ecology. The system uses blockchain, the InterPlanetary File System (IPFS), and MySQL to manage various business data requirements.ResultsExperimental results show that the registration time for each music piece increased by approximately 1.9 s. Additionally, the average feature fingerprint data for each music piece stored on IPFS consumed about 8 MB, which aligns with the expected system performance criteria.DiscussionThe system meets performance expectations, offering secure and efficient copyright registration and evidence storage. The use of blockchain and IPFS provides a scalable, reliable solution for managing digital music copyrights.
NHERI@UTexas experimental facility with large-scale mobile shakers for field studies: a decade of discovery in natural hazards engineering
Authors: Stokoe Kenneth H. , Hwang Sungmoon , Cox Brady R. , Clayton Patricia M. , Gilbert Robert B. 
Published: January 2025

IntroductionNatural hazards present significant risks to infrastructure and communities, emphasizing the importance of advanced tools and methods to better understand and mitigate these challenges. The Natural Hazards Engineering Research Infrastructure (NHERI) experimental facility at the University of Texas (NHERI@UTexas), funded by the National Science Foundation (NSF), addresses this need by offering unique resources for large-scale field testing.MethodsNHERI@UTexas contributes unique, large-scale, literally one-of-a-kind, mobile dynamic shakers and associated instrumentation to investigate seismic, cyclic, and static in-situ testing. These capabilities allow researchers to conduct experiments on actual infrastructure and geotechnical systems under real-world conditions, often impossible to accurately simulate in the laboratory.ResultsNHERI@UTexas has supported pioneering research in several areas, including: (1) enhanced 2D/3D geotechnical and seismic subsurface imaging, (2) in-situ characterization of liquefaction resistance and nonlinear dynamic soil behavior, (3) development of in-situ nondestructive soil-foundation-structure interaction (SFSI) methods, and (4) rapid geotechnical assessments following natural hazard events. These efforts have advanced the validation and calibration of numerical model and methodologies using full-scale experimental data.DiscussionNHERI@UTexas enable researchers to gain new insights and drive innovations in advancing resilient and sustainable solutions for natural hazards problems.
Exploring the mediating role of blood metabolites in the relationship between gut microbiota and gastric cancer risk: a Mendelian randomization study
Authors: Li Xiaocheng , Lin Huapeng , Peng Jing , Gong Jianping 
Published: January 2025

BackgroundPrior studies have established correlations between gut microbiota (GM) dysbiosis, circulating metabolite alterations, and gastric cancer (GC) risk. However, the causal nature of these associations remains uncertain.MethodsWe utilized summary data from genome-wide association studies (GWAS) on GM (European, n=8,956), blood metabolites (European, n=120,241; East Asian, n=4,435), and GC (European, n=476,116; East Asian, n=167,122) to perform a bidirectional Mendelian randomization (MR) analysis, investigating the causal effects of GM and metabolites on GC risk. Additionally, we conducted mediation analysis (two-step MR) to identify potential metabolite mediators in the GM-GC relationship.ResultsWe identified twelve negative and seven positive associations between specific GM taxa and GC risk. For blood metabolites, seven traits were found to be significantly associated with reduced GC risk in the European population, with these findings subsequently validated in the East Asian cohort. Three GM taxa showed potential causal associations with five metabolic traits: the Bacteroidia class and Bacteroidales order were positively correlated with five metabolites (all P &lt; 0.013), while Bacteroides OTU97_27 exhibited a negative correlation with one metabolite (P = 0.007). Two-step MR analysis indicated that total lipids in intermediate-density lipoprotein (IDL), IDL particle concentration, phospholipids in medium low-density lipoprotein (LDL), phospholipids in small LDL, and free cholesterol in small LDL indirectly influenced the association between Bacteroidia class/Bacteroidales order and GC, with mediation proportions of 1.71% (P = 0.048), 1.69% (P = 0.048), 2.05% (P = 0.045), 1.85% (P = 0.048), and 1.99% (P = 0.045), respectively.ConclusionThe present study provides suggestive evidence of a causal relationship between specific GM, blood metabolites, and GC risk, potentially offering new insights into GC etiology.
Identifying subgroup of severe community-acquired pneumonia based on clinical metagenomics, a multicenter retrospective cohort study
Authors: Wang Mingqiang , Jin Yue , Zhang Wenxiao , Ye Ling , Shao Huanzhang 
Published: January 2025

ObjectiveSevere community-acquired pneumonia (sCAP) is one of the major diseases within the ICU. We hypothesize that subtyping sCAP based on simple inflammatory markers, organ dysfunction, and clinical metagenomics results is feasible.MethodIn this study, we retrospectively enrolled immunocompetent sCAP patients requiring invasive mechanical ventilation, who underwent clinical metagenomics from 17 medical centers. We collected data on potentially pathogenic species reported by clinical metagenomics and clinical information for all patients. Latent class analysis (LCA) was applied to routine clinical parameters such as gender, age, white blood cell (WBC), lymphocytes, C-reactive protein (CRP), and Procalcitonin (PCT), identifying two optimally fitting models.ResultsA total of 569 patients were enrolled. Compared to class B, class A was characterized by a younger age, higher CRP and PCT levels, and a higher incidence of coagulation dysfunction, liver failure, circulatory failure, and renal failure. However, the mortality rates were similar between the two groups. In class A, more cases of Streptococcus spp. and fewer cases of HSV-1 and Candida spp. were detected. Among the patients in the two phenotypes, 48.7% and 57.5% received corticosteroid treatment, respectively. In the class A, corticosteroid treatment was not associated with patient mortality (unadjusted hazard ratio (HR)=0.988; 95% confidence interval (CI), 0.634–1.541; p=0.959). In contrast, in the class B group, the use of corticosteroids was associated with a reduced mortality rate (adjusted HR=0.719; 95% CI, 0.525–0.986; p=0.04). Additional analysis showed that in class B, methylprednisolone was associated with reduced mortality (adjusted HR=0.61; 95% CI, 0.44–0.86; p=0.005), while dexamethasone was not associated with mortality (adjusted HR=1.4; 95% CI, 0.89–2.22; p=0.148). In addition, after dose conversion, the results showed that higher doses of corticosteroids in class B were associated with increased mortality (adjusted HR=1.01; 95% CI, 1.00–1.01; p=0.005).ConclusionWe identified two classes based on clinical metagenomics and clinical features. Class B exhibited a better response to corticosteroid compared to class A. The rapid identification of these phenotypes could facilitate the screening of sCAP patients responsive to corticosteroid in future prospective clinical trials.
Chinese patent medicine tongxinluo capsule as a supplement to treat chronic coronary syndromes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials
Authors: Liang Shi-Bing , Wang Yi-Fei , Niu Zhen-Chao , Li Yu-Fei , Zheng Hui-Min , Huan Jia-Ming , Yuan Jie , Robinson Nicola , Liu Jian-Ping , Li Yun-Lun 
Published: January 2025

BackgroundChronic coronary syndromes (CCS) is a common clinical condition that increases the risk of cardiovascular events at any time. Tongxinluo capsules (TXL) are widely used in China for treating CCS.ObjectivesTo systematically evaluate the therapeutic effects and safety of adding TXL to Western medical treatment (WM) for CCS.MethodsWe searched PubMed, Cochrane Library, CNKI, VIP, and Wanfang databases up to August 2024 for randomized controlled trials (RCTs) investigating the therapeutic effects and safety of combining TXL with WM compared to WM alone for CCS. Data analyses were conducted using RevMan 5.4 software.ResultsTwenty studies involving 2091 participants were identified. Evidence supports the use of TXL plus WM for reducing angina frequency [SMD −2.50, 95% CI (−3.53, −1.48)], improving seattle angina questionnaire scores (P &lt; 0.05), decreasing nitroglycerin dose [SMD −1.63, 95% CI (−2.26, −1.00)], and shortening angina duration [MD −1.50 min/once, 95% CI (−1.98, −1.02)]. Adding TXL to WM showed a non-significant trend toward reducing myocardial infarction [RR 0.34, 95% CI (0.05, 2.12); NNT = 41] and sudden cardiac death [RR 0.34, 95% CI (0.01, 8.28); NNT = 65]. No increase in adverse events was observed when TXL was added to WM [RR 1.02, 95% CI (0.70, 1.49); NNT = 149].ConclusionsOur review suggests that TXL may offer additional therapeutic benefits for CCS patients and appears to be safe when combined with WM. Further investigations are warranted to confirm the potential impact of adding TXL to WM for CCS.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024499031, PROSPERO (CRD42024499031).
The sound of science: a sonification learning experience in an Italian secondary school
Authors: Eramo Giacomo , Pastore Serafina , De Tullio Mario , Rossini Valeria , Monno Alessandro , Mesto Ernesto 
Published: January 2025

IntroductionThe present article reports on a case study aimed at improving STEAM education in secondary schools. It discusses the use of sonification as a teaching strategy to integrate music into science learning, using different approaches from data audification to parameter mapping into aural models and to the rewriting of song lyrics based on STEM topics.MethodsA qualitative research study has been performed in a secondary school in the school district of Bari (South of Italy). More specifically, students’ and experts’ perceptions of experienced sonification activities have been collected through six rounds of focus group interviews.ResultsWhile there was a good improvement in student achievement in science, it is worth noting how musical activities also led to some benefits for students involved in the sonification workshops. The integration of music with STEM disciplines has promoted more cooperation and empathy among the students. Additionally, musical inputs can help students discover and regain interest in music. However, the study also highlighted the differences in teacher training and content knowledge, suggesting the need for future research to consider broader samples and experimental designs.DiscussionResults and implications for educational research and practice are discussed considering the recent literature on STEAM. Finally, this study demonstrates the importance of a robust instructional design for sonification activities, so that they can be more effective, aligned with the school curriculum, and integrated into the classroom teaching-learning process.