bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’assistance médicale à la procréation avec tiers donneur à la suite de la loi du 2 août 2021
Authors: Mesnil Marie 
Published: March 2023

La loi du 2 août 2021 relative à la bioéthique a fait évoluer le droit de l’assistance médicale à la procréation avec tiers donneur de manière assez significative, sans pour autant rompre avec les principes éthiques fondateurs : les couples de femmes et les femmes seules non mariées peuvent bénéficier d’un don de spermatozoïdes, l’autoconservation de gamètes sans motif médical est autorisée et un accès à l’identité et aux données non identifiantes du donneur a été aménagé pour les personnes conçues à partir d’un don de gamètes. Ces évolutions importantes ne doivent toutefois pas masquer les nombreuses incertitudes qui demeurent quant à l’usage des gamètes au sein du couple – lorsque celui-ci est constitué de deux femmes ou d’une personne trans – ou encore quant à l’accès plus général à l’ amp pour les personnes qui ont changé de mention de sexe à l’état civil.
Le budget participatif clermontois, exemple d’un dispositif participatif qui devient le catalyseur des enjeux environnementaux
Authors: Éric Agbessi , Nicolas Duracka 
Published: March 2023

Le Budget Participatif de la Ville de Clermont-Ferrand est une politique publique qui répond à une triple situation de crise démocratique (de l’autorité politique et scientifique, de la participation démocratique et de la délibération publique). Sur les 32 projets votés par les citoyens, un quart ont une teneur écologique. Ainsi, les micros espaces publics délibératifs ouverts par l’initiative ont été marqués par une fragmentation. Premièrement, une tendance à produire des échanges régulés par une vision « instituée » du développement durable remettant très peu en cause notre modèle de développement citadin. Deuxièmement, l’émergence d’une forte incommunication et la marginalisation des porteurs de projets porteurs de visions transformatrices (décroissantes ou résilientes).
MASP3 Deficiency in Mice Reduces but Does Not Abrogate Alternative Pathway Complement Activity Due to Intrinsic Profactor D Activity
Authors: Gullipalli Damodar , Miwa Takashi , Golla Madhu , Sato Sayaka , Angampalli Sree , Song Wen-Chao 
Published: March 2023

Abstract
Complement factor D (FD) is a rate-limiting enzyme of the alternative pathway (AP). Recent studies have suggested that it is synthesized as an inactive precursor and that its conversion to enzymatically active FD is catalyzed by mannan-binding lectin-associated serine protease 3 (MASP3). However, whether MASP3 is essential for AP complement activity remains uncertain. It has been shown that Masp1/3 gene knockout did not prevent AP complement overactivation in a factor H–knockout mouse, and a human patient lacking MASP3 still retained AP complement activity. In this study, we have assessed AP complement activity in a Masp3-knockout mouse generated by CRISPR/Cas9 editing of the Masp1/3 gene. We confirmed specific Masp3 gene inactivation by showing intact MASP1 protein expression and absence of mature FD in the mutant mice. Using several assays, including LPS- and zymosan-induced C3b deposition and rabbit RBC lysis tests, we detected plasma concentration–dependent AP complement activity in Masp3 gene–inactivated mice. Thus, although not measurable in 5% plasma, significant AP complement activity was detected in 20–50% plasma of Masp3 gene–inactivated mice. Furthermore, whereas FD gene deletion provided more than 90% protection of CD55/Crry-deficient RBCs from AP complement-mediated extravascular hemolysis, Masp3 gene deletion only provided 30% protection in the same study. We also found pro-FD to possess intrinsic catalytic activity, albeit at a much lower level than mature FD. Our data suggest that MASP3 deficiency reduces but does not abrogate AP complement activity and that this is explained by intrinsic pro-FD activity, which can be physiologically relevant in vivo.
In Vitro Investigation of Insulin-Like Growth Factor-I and Mechano-Growth Factor on Proliferation of Neural Stem Cells in High Glucose Environment
Authors: Gürbüz Tuğba Aydintug , Güleç Çağri , Toprak Fatih , Toprak Selin Fulya , Sozer Selcuk 
Published: March 2023

Objective:
High glucose levels cause metabolic and vascular complications by affecting the nervous system with an increased risk of stroke and seizures. There are still no effective treatment modalities for the high morbidity and mortality rates detected in such situations. Neural stem cells (NSCs) provide neurogenesis in the nervous system, but high glucose is detrimental to NSCs. This study investigates the intrinsic and extrinsic effects of the growth factors insulin-like growth factor-I (IGF-I) and mechano-growth factor (MGF) on NSCs when exposed to high glucose levels. Thus, the possibility of new treatment options for diabetes patients is explored.

Materials and Methods:
Rat NSCs grown in cell culture conditions were exposed to a control glucose concentration of 17.5 mM and high concentrations of 27.75, 41.75, and 83.75 mM for 24 h. The high glucose concentrations were designed to recapitulate the in vivo conditions of diabetes mellitus, diabetic ketoacidosis, and hyperglycemia hyperosmolar status. Then, 0.2 μg/ml IGF-I and MGF growth factors were separately added and their expressions in the NCSs investigated by real-time reverse transcription-polymerase chain reaction. The effects of exogenous IGF-I and MGF administration on NSC proliferation under high glucose conditions were measured by BrdU incorporation assay using flow cytometry analysis.

Results:
A significant increase was detected in the relative gene expression fold changes of IGF-I and MGF in the NSCs. The MGF relative fold change was greater than the IGF-I for each high glucose condition. NSCs exposed to 27.75 mM glucose revealed a 17-fold and 40-fold increase in the IGF-I and MGF gene expressions, respectively; the 41.75 mM glucose similarly revealed 68-and 161-fold increases and the 83.75 mM glucose 75-and 137-fold increases. Exogenous IGF-I administration increased its expression profile, while the administration of MGF lowered its expression. The NSC was in the growth (G0/G1) phase of the cell cycle during the 24 h culture time. The percentage of proliferated NSC decreased to 89% (17.5 mM), 85% (27.75 mM), 50.30% (41.75 mM), and 28.97% (83.75 mM). Surprisingly, the increase in both IGF-I and MGF saved the NSCs from cell death.

Conclusion:
Exogenous IGF-I and MGF administrations via high glucose environments increased NSC proliferation at the time of injury and protected the NSCs from cell death. The neuroprotective effect of MGF was greater than that of IGF-I. Thus, due to their neurogenesis potential, exogenous IGF-I and MGF could be applied in the treatment of diabetes patients to relieve neural damage.
The Relationship between Transversus Abdominis and Internal Oblique Thickness and Disease-Related Characteristics in Parkinson's Disease
Authors: Aktar Burcin , Ozyurek Seher , Goz Evrim , Colakoglu Berril Donmez , Balci Birgul 
Published: March 2023

Background and Aim:
The core muscles are essential for spinal stability during functional activities. Trunk muscle function is affected by specific neurodegenerative processes of Parkinson's disease (PD). This study aimed to investigate whether changes in transversus abdominis (TrA) and internal oblique (IO) thickness during the abdominal drawing-in maneuver (ADIM) were associated with clinical manifestations, core endurance, and functional mobility in patients with PD.

Materials and Methods:
We included patients with a modified Hoehn and Yahr staging of 3 or lower. TrA and IO muscle thickness were measured using ultrasound both at rest and during ADIM, and the percent change (%) was calculated to assess TrA and IO activation. Patients performed core endurance (prone bridge and sit-ups) and functional mobility tests (timed “up and go” [TUG] and five times sit-to-stand [FTSTS]). All assessments were conducted during the “on” phase.

Results:
Five female and 17 male patients were included in this study. We found a statistically significant correlation between ultrasound parameters of IO and the clinical manifestations of PD (P < 0.05). Correlations were observed between TrA percent change and prone bridge, sit-ups, TUG, and FTSTS (P < 0.05).

Conclusion:
To the best of our knowledge, this is the first ultrasound imaging-based study to demonstrate the relationship between TrA and IO muscle thickness and clinical outcomes, and functional performance in patients with PD. Percentage changes in IO were associated with the clinical manifestations of PD. Increased activation of TrA during ADIM was associated with improved core endurance and mobility. The results suggest that a trunk-specific exercise program may be the cornerstone in the treatment of PD-related changes.
Evaluation of Eosinophil-to-Lymphocyte Ratio before and after Immunotherapy in Pediatric Allergic Rhinitis Patients
Authors: Yenigun Alper , Dagistanli Nurtac , Polat Emre , Dogan Remzi , Nursoy Mustafa Atilla , Ozturan Orhan 
Published: March 2023

Objective:
The aim of this study is to calculate the eosinophil-to-lymphocyte ratio (ELR) before and after the treatment with subcutaneous immunotherapy (SCIT) and to investigate if ELR decreases after the treatment. The results will support our hypothesis of using the ELR as a diagnostic and prognostic parameter in allergic rhinitis (AR) patients.

Study Design:
This study was planned and performed as a case–control study.

Materials and Methods:
In this prospective study, we have collected the data from 68 pediatric patients (aged between 9 and 18 years) who have been treated with 4-year SCIT and whose skin prick test was negative after treatment of AR. ELRs were compared based on the hemogram results before SCIT and approximately 4 years later. Patients who have the inflammatory disease were eliminated from the study since lymphocytes were increased in the blood biochemistry tests.

Results:
When the eosinophil counts were compared before and after the immunotherapy, it was observed that the eosinophil ratios were decreased from 7.14 ± 4.63 to 4.55 ± 2.98; (P = 0.000) after treatment. Lymphocyte count also decreased from 34.8 ± 10.3 to 32.9 ± 8.3 (P = 0.091). After SCIT, ELRs were significantly lower (P < 0.001). While the mean ± standard deviation (SD) value of ELR was 0.18 (0–0.66) before the treatment, the mean ± SD value after SCIT was 0.11 (0.01–0.67). Total immunoglobulin E decreased from 96.9 ± 10 to 82 ± 11, which was not statistically significant (P = 0.058).

Conclusion:
A statistically significant decrease in ELR was observed in patients whose skin prick test was negative after immunotherapy. ELR would be as valuable as a skin prick test for diagnostic and prognostic purposes.
Effect of Vaccination on Coronavirus Disease 2019-Related Olfactory Dysfunction
Authors: Alhazmi Abdulaziz , Darraj Hussam , Aqeel Abdulrahman , Khormi Ghadah , Hakami Alshomokh , Kariri Abdulaziz , Siddiq Afnan , Sahli Ali , Othathi Rahaf , Sumaily Ibrahim 
Published: March 2023

Background:
Hyposmia and anosmia are the reduced ability and inability to perceive odors, respectively. Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus that was first detected in late 2019 in China and has spread globally since mid-February 2020. Olfactory dysfunction (OD), such as anosmia or hyposmia, is an important early indicator of COVID-19.

Objective:
This study aimed to compare the incidence and duration of COVID-19-related hyposmia before and after vaccination.

Design:
This was cross-sectional study.

Setting:
Jazan region, February–July 2022.

Patients and Methods:
Data were collected from the adult population of the Jazan region using a self-administered questionnaire in the Arabic language. Data are presented as frequencies and percentages for categorical variables. Analysis of variance was used to compare means between groups while the Chi-square test was used for the comparison of categorical variables. Statistical significance was set at P < 0.05.

Main Outcome Measures:
The incidence and duration of COVID-19-related OD before and after vaccination.

Sample Size:
The sample size was 466.

Results:
Of the 510 respondents, 466 met the study criteria. OD just after receiving the vaccines was reported by 53 (12.2%) participants. COVID-19 was confirmed in 268 participants (52.5%; 118 men and 150 women); of these, 163 (60.8%) had OD and 144 (53.7%) reported taste dysfunction. OD was more frequent in women than in men (66.7% vs. 53.4%, P = 0.03) and was the only symptom in 10 respondents (3.7%). OD was less frequent in postvaccination infection (54.9% vs. 73.8%, P = 0.003). Moreover, the OD duration was significantly shorter in postvaccination COVID-19 infection (improvement in the 1st week, 66.3% vs. 33.9%, P = 0.001).

Conclusions:
Among patients with COVID-19, OD occurs less frequently in men and after vaccination, and the duration is shorter after vaccination.

Limitations:
This study was limited by the small sample size, cross-sectional design, and small number of respondents with common chronic diseases such as diabetes and hypertension.
Orbital metastasis of myxofibrosarcoma
Authors: Shoji Marissa K. , Stevens Shanlee M. , Ohana Oded , Clauss Kevin D. , Tang Vincent D. , Khzam Rayan Abou , Rosenberg Andrew E. , Dubovy Sander R. , Lee Wendy W. 
Published: March 2023

Abstract
Myxofibrosarcoma (MFS), a common sarcoma in adults, typically affects the extremities. Primary orbital involvement is uncommon, and orbital metastasis is exceedingly rare. We describe a case of orbital MFS due to metastasis and provide an updated literature review. A 56-year-old woman presented with 2 months of progressive right eye proptosis. Relevant history included left palmar MFS excised 2 years prior. Examination demonstrated proptosis and restriction in abduction of her right eye without optic nerve compromise. Imaging revealed a well-circumscribed right orbital mass. Initial biopsy showed glandular tissue with chronic inflammation without an evidence of malignancy. She subsequently developed worsening proptosis, complete ophthalmoplegia, and a new afferent pupillary defect. Repeat orbital excisional biopsy with deeper dissection demonstrated high-grade MFS consistent with metastasis. She underwent chemoradiation with resolution of her lesion. Literature review identified 12 previously reported cases of MFS, only two of which involved metastasis to the orbit and were associated with worse prognosis. This report highlights a rare case of orbital metastasis of MFS with high-grade features confirmed on histopathology and provides an updated literature review. Prompt diagnosis and complete removal of MFS located both systemically and in the orbit are essential due to the metastatic potential.
Removal of Pb2+ from industrial wastewater using activated carbon from Persea americana seed
Authors: Dunoyer Arnulfo Tarón , Carrillo Luis Enrique Guzmán , Castillo Fredy Colpas 
Published: March 2023

Activated carbon is a material that has various environmental applications, such as the adsorption of metallic lead ions (Pb2+). It can be obtained from different plant species. In this research, the seed of Persea americana (Avocado- HASS variety) was obtained from local markets in the city of Cartagena to be used in the removal of Pb2+ from wastewater from the fishing industry. To obtain activated carbon, the seed was carbonized in a Terrigeno-brand clay oven, Model DB 1200. Orthophosphoric acid at 21% w/v was used as an activating agent. The residual water was characterized following the APHA specifications. The turbidity was determined by nephelometry in a Turbiquant 300 IR turbidimeter. The Pb2+ concentration was determined by atomic absorption spectroscopy in a Thermo Scientific iCE 3300 equipment. The chemical surface of the material was performed by Fourier transform infrared spectroscopy (FTIR). The carbons were morphologically characterized using a scanning electron microscope SEM (Jeol 5910LV), visualized at 15kV. A yield of 20.38% by mass of coal is achieved. The pores are of irregular size, ranging from 16.2 to 55.98 μm. 65% of Pb2+, turbidity (57.6%), color (57%), total solids (50.2%), as well as BOD (53.12%) and COD (36%) are removed, finding statistically significant differences in values at the 95% level of significance. The seed of Persea americana (HASS avocado) can serve as plant material to obtain an adsorbent material (activated carbon) and be used in the removal of Pb2+ from wastewater.
Keywords: activated carbon, adsorption, avocado seeds (HASS variety), Pb2+, removal.
Synthesis, Characterization, and Biological Evaluation Of [1,2,4 ]-Triazole-3yl]Sulfanyl Acetamide Derivative
Authors: Hotta Santanu Kumar , Rout Sudhanshu Sekhar , Kumar Anjan 
Published: March 2023

A significant portion of recent papers is in the field of Mercapto substituted Triazole moiety received considerable attention in the literature.Characterization and Antibacterial activity against important medically Gram positive Bacteria likely Actinomyces, Clostridium, Mycobacterium, Strptococci, Staphylococci and Nocardia.Triazole is a class of N-Bridged Heterocyclic compounds especially in Chemotherapy. Triazole moiety seems to be very small but 1,2,4-Triazole derivatives have wide range of potential antibacterial activities against drug-resistant pathogens.Hybridization shows a high potential to develop novel drugs,reduce toxicity,and improve Pharmacokinetic profiles.More effective antibacterial studies might be obtained by the hybridization of 1,2,4-Triazole mercapto moiety. A number of clinically effective antibacterial drugs become more effective. Therefore, we shed, herein, more light on novel synthetic drug and its antibacterial activity.
REAPER MAN, TEACHER MAN: USING POPULAR CULTURE TO TEACH GRIT, MORTALITY AWARENESS, AND GOAL SETTING IN THE AGE OF ANXIETY
Authors: Von Goble Brant 
Published: March 2023

<p>Since the advent of low-cost modern media technologies (records, films, radio, television, and the internet), <em>popular culture</em> has both shaped and been shaped by complex economic, political, governmental, moral, and artistic concerns. <em>Fear and anxiety</em> and the human capacity to control, reduce, or induce them in others have been tools for influencing both individual and societal behaviours for far longer. At the juncture of these two are both opportunity and hazard. This paper will briefly consider the historical context of our current apprehensiveness and collective neuroticism from the early media age to the present and how anxiety has been used by significant power players and the nominally disadvantaged alike. It will then turn to the role of media technologies in distorting our understanding of risk, mortality, and the potential for (and the sustainability and importance of) happiness. Finally, it will present a series of suggestions to produce more resilient, realistic, and goal-oriented learners by cultivating within them a robust understanding of their mortality, the inevitability of suffering, and the tenuousness of the human condition. Much of the material and culture referenced will be from the United States; however, the observations and suggestions throughout this paper should be broadly applicable to the peoples of the developed world. Finally, this paper will include ample content and conversational suggestions, examinations of media context and interpretations, and questions for classroom discussion for the teacher who wishes to guide students towards a better-grounded mental state.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0097/a.php" alt="Hit counter" /></p>
TEACHER INSIGHTS ON POLLUTION
Authors: Akar Elif , Genç Hasan 
Published: March 2023

The aim of this research is to determine the level of information and awareness for the environment of teachers who are working in the schools in Gonen district of Isparta. The study group of the research consists of 16 volunteer teachers, 6 science sciences and 10 classroom teachers, who work in the schools in Gonen district of Isparta. As a research model, a descriptive research method was used from qualitative research methods. The research uses a semi-structured interview form developed by the researcher as a data collection tool. The semi-structured interview form contains a total of 9 questions. Descriptive analysis and content analysis were used to analyze data from the semi-structured interview form applied in the research. According to the research findings, teachers have no deep knowledge of the diversity of environmental pollution. It is seen that teachers are emphasizing physical and environmental pollution that they create superficially when talking about the presence of factories in the region. It was concluded that the source of livelihood was on agricultural activity and that the agricultural drugs used reduced the soil efficiency. To preserve the natural structure in the region, the village and the city can be conscious of students and teachers. Plans and projects can be designed under a heading to reduce environmental pollution. Social activities related to the environment can be organized to promote the natural beauty of the region.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0023/a.php" alt="Hit counter" /></p>
AN INVESTIGATION INTO ORGANIZATION ERRORS IN EFL LEARNERS’ PARAGRAPH WRITING: A CASE IN A FOREIGN LANGUAGE CENTER IN CAN THO CITY, VIETNAM
Authors: Giang Hoang Thi Lien , Dan Thai Cong , Han Thai Phan Bao 
Published: March 2023

Committing errors is an inevitable phenomenon that happens to learners in the process of learning a foreign language, especially in writing skill. For many years, diagnosing what types of errors learners commonly made and why they are prone to committing such errors has become a great concern to language educators and researchers. The present study investigated organization errors in English compositions produced by 60 Vietnamese pre-intermediate learners on one task. The author collected data by writing tests and participant questionnaires. Analyses of the errors and survey data yielded the following main findings: (1) Among the five categories of organization errors, incoherence accounted for the largest percentage, followed by the poor topic sentence, disunity, poor conclusion and no conclusion; (2) There is a significant difference between the two genders in terms of the category of incoherence. Nevertheless, the difference in the other organization error categories between the two groups of participants was insignificant; (3) Several reasons were identified for the errors such as the lack of writing practice and the influence of Vietnamese.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0028/a.php" alt="Hit counter" /></p>
INVESTIGATING PRAGMATIC TRAPS IN ADVERTISING MESSAGES OF ZAIN – IRAQ TELECOMMUNICATION COMPANY
Authors: Kadhim Basim Jubair 
Published: March 2023

This paper discusses the use of pragmatic traps in advertising messages and their impact on customers, with a particular focus on the messages of Zain Telecommunication Company in Iraq. Pragmatic traps are false or misleading claims in advertising that deceive customers by distorting the reality of the product or service being offered. The research aims to investigate the extent to which Zain uses pragmatic traps in its advertisements and how these traps affect customers. The analysis of fifty advertising messages from Zain reveals a high use of persuasive language, emotional appeals, particularized and coded implicature, and violations of the maxims of quantity and quality of the cooperative principle. These findings highlight the importance of understanding the elective model of pragmatic traps in advertising and the ways in which advertisers can use language to manipulate the context and meaning of a message. As customers, it is important to be aware of these traps to make informed purchasing decisions.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0028/a.php" alt="Hit counter" /></p>