bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-modal congruency effects in online service settings: a telepresence – stereotype content perspective
Authors: Orth Ulrich R. , Meyer Caroline , Timm Jule , Reimers Felix , Bouzdine-Chameeva Tatiana 
Published: February 2025

Purpose
This study aims to integrate research on multimodal congruency with the stereotype-content model to offer a novel explanation of why and when consumers respond favorably to vision-sound congruency in online service settings.

Design/methodology/approach
A mixed methods approach included a field study (360° panoramic desktop-virtual tour of a winery) and a laboratory study (fully immersive virtual realtiy (VR) tour of a pub). The explanatory mechanism was tested through conditional process analyses, specifically, a custom-made serial mediation model where effects of cross-modal congruency were channeled through telepresence and warmth/competence with familiarity with the service provider included as a moderator. Category knowledge and involvement were included as controls. Study 2 additionally accounted for sensory olfactory and haptic information present in the consumer’s physical location.

Findings
Congruency between vision and sound positively influences consumer intention to visit the environment in person, to purchase online and to engage in positive word-of-mouth. These effects are channeled through enhanced feelings of telepresence as well as more favorable perceptions of service provider warmth. Congruency effects are robust in the presence of additional sensory input in the offline environment and across levels of involvement and knowledge but may depend on a consumer’s familiarity with the setting.

Research limitations/implications
The study offers a novel process explanation for how cross-modal congruency in online service settings influences consumer intention. Examining two specific sensory modalities and two service settings presents limitations.

Practical implications
The findings help service providers to better understand how perceptions of warmth and competence transmit cross-modal congruency effects, resulting in more favorable responses.

Originality/value
To the best of the authors’ knowledge, this work is among the first to adopt a stereotype-content and multimodal congruency perspective on consumer response to online service settings.
Evaluating staff training on the trauma model of psychosis and trauma-informed care in a CMHT
Authors: Gregory Polly , Colbert Susannah 
Published: February 2025

Purpose
Links between trauma and psychosis have been well evidenced. Trauma has been proposed to underlie psychotic experiences, with the trauma model of psychosis suggesting psychotic experiences represent forms of trauma-related distress. As such, traumatic experiences can be seen symbolised in the content of psychosis experiences. Despite this, Community Mental Health Teams (CMHTs) predominantly operate within a medicalised model, where trauma and trauma-informed care are often neglected. Therefore, staff training was delivered on the trauma model of psychosis and trauma-informed care. This study aims to assess whether the training would improve knowledge and attitude in working with trauma and whether the training would improve staff recognition of the connections between the content of psychosis and previous trauma.

Design/methodology/approach
The training consisted of an online 1-h session, with measures of trauma-informed care (knowledge and attitude) and trauma-psychosis links (symbolism questionnaire) collected pre- and post-training. The training was open to all 115 staff in the CMHTs, 53 attended, however, only 23 completed both pre- and post-measures.

Findings
Wilcoxon signed-rank tests revealed significant differences in pre- and post-performance on both the trauma-informed care and symbolism questionnaire. Findings showed in this sample that the training improved knowledge and attitude in trauma-informed care and staff ability to recognise connections between trauma and psychotic experiences.

Originality/value
A novel symbolism questionnaire was designed for this evaluation. The findings extend the literature, as they show that staff were more accurate in recognising the specific underlying trauma to the psychosis content following training.
Buoyancy characteristic analysis and optimization of precast concrete slab track during casting process of self-compacting concrete
Authors: Wang Pengsong , Xin Tao , Chen Peng , Wang Sen , Cheng Di 
Published: February 2025

PurposeThe precast concrete slab track (PST) has advantages of fewer maintenance frequencies, better smooth rides and structural stability, which has been widely applied in urban rail transit. Precise positioning of precast concrete slab (PCS) is vital for keeping the initial track regularity. However, the cast-in-place process of the self-compacting concrete (SCC) filling layer generally causes a large deformation of PCS due to the water-hammer effect of flowing SCC, even cracking of PCS. Currently, the buoyancy characteristic and influencing factors of PCS during the SCC casting process have not been thoroughly studied in urban rail transit.Design/methodology/approachIn this work, a Computational Fluid Dynamics (CFD) model is established to calculate the buoyancy of PCS caused by the flowing SCC. The main influencing factors, including the inlet speed and flowability of SCC, have been analyzed and discussed. A new structural optimization scheme has been proposed for PST to reduce the buoyancy caused by the flowing SCC.FindingsThe simulation and field test results showed that the buoyancy and deformation of PCS decreased obviously after adopting the new scheme.Originality/valueThe findings of this study can provide guidance for the control of the deformation of PCS during the SCC construction process.
The artificial intelligence automation dilemma: lessons from recent labour disputes in Australia
Authors: Tenakwah Emmanuel Senior , Amankwaa Albert 
Published: February 2025

Purpose
This paper aims to highlight the crucial role of strategic human resource management in addressing labour tensions that arise from the integration of artificial intelligence (AI) and automation in contemporary workplaces. Effective approaches to managing technological transformation while maintaining positive labour relations are also discussed.

Design/methodology/approach
The paper draws upon two labour dispute cases at supermarket giants, Woolworths and the aviation sector in Australia. The cases are analysed through the lens of strategic human resource management and discussed using previous studies, expert and industry insights.

Findings
This paper reveals that successful AI integration requires more than technological expertise – it also demands sophisticated people management strategies that can balance innovation with human concerns. To do so, there is a need for strategic workforce planning and AI integration, cultural transformation and change management, ethical considerations and worker well-being, balancing efficiency and human agency and leadership in AI transformation. Comprehensive strategy development, stakeholder engagement, governance structures and skills development are recommended for smooth AI integration in modern workplaces.

Originality/value
This paper uses two recent labour disputes in Australia to illuminate the critical role of strategic HR management in balancing AI integration with employee well-being and engagement. As AI and automation continue to reshape workplaces, technological transformation must serve both organisational objectives and worker interests. Lessons from this paper can guide future strategic HR approaches to AI integration in ways that promote sustainable and equitable workplace transformation.
Effect of corporate social responsibility-moderated digital marketing on small and medium enterprises performance in the emerging market
Authors: Thy Ngo Giang , Binh Tu Van , Duong Linh 
Published: February 2025

Purpose
With the wide adoption of information and communication technologies globally, digital marketing (DM) has emerged as an important and influential role in the growth and development of firms. However, it remains unclear how small and medium enterprises (SMEs) in emerging markets that normally have limited digital technology resources can gain benefits from DM. Thus, this research aims to investigate how DM benefits SMEs in emerging markets.

Design/methodology/approach
Drawing on the resource-based views (RBV) theory and a sample of 156,625 SMEs in Vietnam, this research uses statistical models and examines the performance of SMEs in terms of sales and productivity.

Findings
There is strong evidences that the sales and productivity performance of SMEs are positively affected by DM. Furthermore, there is evidence that corporate social responsibility plays an important role in moderating the influence of DM on SME performance.

Originality/value
This finding suggests that entrepreneurs should carefully consider using digital technologies to create DM strategies. This result also encourages local policymakers to invest more in digital technology and boost the growth of SMEs.
Frontline Staff and Trainer Perspectives on Implementing and Adhering to Positive Behaviour Support in Intellectual Disabilities Care: A Mixed‐Methods Study
Authors: Bruinsma Eke , de Bildt Annelies A. , Hoekstra Pieter J. , de Kuijper Gerda M. , van den Hoofdakker Barbara J. 
Published: February 2025

ABSTRACTBackgroundWe aimed to identify key factors in implementing and adhering to positive behaviour support (PBS), provided by frontline staff, targeting challenging behaviours of people with intellectual disabilities living in residential group homes.MethodUsing semi‐structured interviews with 12 frontline staff members, we collected perspectives on a PBS training that they received. In two separate focus groups with nine frontline staff members and nine PBS trainers, we discussed factors perceived to influence PBS implementation and adherence. Hybrid coding and thematic analysis were employed.ResultsFrontline staff were positive about the content of the training and noticed improvements in challenging behaviours of the people they cared for. Key factors for implementation and adherence included organisation‐wide embedding of PBS, management support, motivating staff, clear documentation, regular evaluations, and additional training sessions.ConclusionsThis study provides valuable insights for the implementation of and adherence to frontline staff‐provided PBS.
The Effect of Early‐Initiated Half‐Swaddling and Kangaroo Care Practices on Maternal Sleep Quality and Postpartum Depression in Term Infants: A Randomized Controlled Trial
Authors: Küçükkaya Burcu , Cihangir Öztürk Tülay , Erginler Gonca , Temiz Mehtap , Erçel Özge 
Published: February 2025

ABSTRACTThis study aimed to investigate the effects of half‐swaddling and kangaroo care practices early initiated in mothers of term babies on maternal sleep quality and postpartum depression. This study was prospective, four‐arm randomized controlled trial. This study was conducted in 136 mothers and term baby hospitalized in Trakya University Hospital between April 2023 and August 2024. Participants were randomly divided into four groups using computer program with 34 mothers in each group: control (A), half‐swaddling (B), kangaroo care (C), half‐swaddling, and kangaroo care (D). Starting, 1st, 2nd, 3rd, and 6th months, the data of all four groups were collected with the Questionnaire Form, Edinburgh Postpartum Depression Scale (EPDS), and Pittsburgh Sleep Quality Index (PSQI). Bonferroni and multiple linear regression (MLR) were used for advanced statistics. C and D groups had more positive effects on depression, while B and D groups had more positive effects on maternal sleep quality (p < 0.001). The combination of half‐swaddling and kangaroo care practices early initiated in term babies has a significant effect on reducing the risk of postpartum depression, and half‐swaddling practice has an important effect on improving maternal sleep quality.Trial Registration: ClinicalTrials.gov: NCT06348316
Deletion of the
chloroquine resistance transporter
gene confers reduced piperaquine susceptibility to the rodent malaria parasite
Plasmodium berghei
Authors: Hirai Makoto , Arai Meiji , Hayamichi Soki , Uchida Ayako , Sudo Megumi , Kubota Rie , Shinzawa Naoaki , Mita Toshihiro 
Published: February 2025

ABSTRACT

Malaria parasites acquire drug resistance through genetic changes, the mechanisms of which remain incompletely understood. Understanding the mechanisms of drug resistance is crucial for the development of effective treatments against malaria, and for this purpose, new genetic tools are needed. In a previous study, as a forward genetic tool, we developed the rodent malaria parasite
Plasmodium berghei
mutator (PbMut) line, which has a greatly increased rate of mutation accumulation and from which we isolated a mutant with reduced susceptibility to piperaquine (PPQ). We identified a mutation in the
chloroquine resistance transporter
(PbCRT N331I) as responsible for this phenotype. In the current study, we generated a marker-free PbMut to enable further genetic manipulation of the isolated mutants. Here, we screened again for PPQ-resistant mutants in marker-free PbMut and obtained a parasite population with reduced susceptibility to PPQ. Of five isolated clones, none had the mutation PbCRT N331I; rather, they possessed a nonsense mutation at amino acid 119 (PbCRT Y119*), which would truncate the protein before eight of its ten predicted transmembrane domains. The PbCRT orthologue in the human malaria parasite
Plasmodium falciparum
, PfCRT, is an essential membrane transporter. To address the essentiality of PbCRT, we successfully deleted the full
PbCRT
gene [
PbCRT
(−)] from wild-type parasites.
PbCRT
(−) parasites exhibited reduced susceptibility to PPQ, along with compromised fitness in mice and following transmission to mosquitoes. Taken together, our findings provide the first evidence that
P. berghei
can acquire reduced PPQ susceptibility through complete loss of PbCRT function.
A phase I, single-center, randomized, open-label, three-period crossover study to evaluate the drug–drug interaction between ZSP1273 and oseltamivir in healthy Chinese subjects
Authors: Pang Yanqing , Li Haijun , Chen Xuemei , Cao Yingying , Jiang Hui , Huang Jufang , Liu Yiming 
Published: February 2025

ABSTRACT

ZSP1273 is a novel small-molecule anti-influenza drug that targets the RNA polymerase PB2 subunit, while oseltamivir is the first-line medication that inhibits neuraminidase. ZSP1273 showed high efficacy against human influenza viruses both
in vitro
and
in vivo
, including oseltamivir-resistant strains
in vitro
. In future clinical applications, the combination of these two antiviral drugs with different mechanisms can reduce the potential for antiviral resistance that may arise from monotherapy. To evaluate the drug–drug interaction between ZSP1273 and oseltamivir by the pharmacokinetics and safety of co-administration in healthy subjects, a phase I, single-center, randomized, open-label, three-period crossover study was conducted. Thirty-six subjects enrolled were randomized in a 1:1:1 ratio into three crossover treatment sequences with oral administration detailed as follows: treatment A: ZSP1273 tablets 600 mg once daily (QD) for 5 days; treatment B: oseltamivir capsules 75 mg twice daily (BID) for 5 days; treatment C: ZSP1273 tablets 600 mg once daily (QD) + oseltamivir capsules 75 mg twice daily (BID) for 5 days. Plasma samples were collected from all subjects at scheduled time points after drug administration to measure the plasma concentrations of ZSP1273, oseltamivir, and its active metabolite oseltamivir carboxylate, for pharmacokinetic analysis. Compared with monotherapy, the geometric mean ratios (90% confidence intervals) of C
max,ss
, AUC
0-t,ss
, AUC
0-τ,ss
, and AUC
0-∞,ss
for ZSP1273 after co-administration were all within the ineffective boundary range of 80% to 125%, supporting that no drug–drug interaction occurs with ZSP1273. After co-administration, the AUC
0-t,ss
, AUC
0-τ,ss
, and AUC
0-∞,ss
of oseltamivir were all within 80% to 125%, while C
max,ss
decreased by 39.9%. The pharmacokinetic parameters above of oseltamivir carboxylate remained within 80%–125%, except only the lower bound of the 90% CI for C
max,ss
slightly below 80% (77.0%). Considering the rapid metabolism of oseltamivir into the active metabolite oseltamivir carboxylate and the minor impact of co-administration on the pharmacokinetic parameters of oseltamivir carboxylate, it is believed that no clinically significant drug–drug interaction was observed with the combination of these two drugs. During the trial, the safety and tolerability of both combination therapy and monotherapy were good, with no increased safety risks observed from the combination therapy.

CLINICAL TRIALS

This study is registered with ClinicalTrials.gov as
NCT05108051
.
In situ
structures of the contractile nanomachine myophage Mu in both its extended and contracted states
Authors: Zhou Junquan , Wang Liwen , Xiao Hao , Chen Wenyuan , Liu Zhonghua , Song Jingdong , Zheng Jing , Liu Hongrong 
Published: February 2025

ABSTRACT

Myophage Mu is a representative of contractile nanomachines with a simple tail baseplate. It has the capacity to infect a range of intestinal bacteria and has extensive applications in genetic engineering research. Nevertheless, a comprehensive understanding of the entire structure and contractile mechanisms of Mu remains elusive. Using cryo-electron microscopy (cryo-EM), we resolved the asymmetric structures of Mu in both its extended and contracted states, the latter of which lacked the tail baseplate, at near-atomic resolutions. We built the atomic models for the extended Mu, encompassing the head, the connector complex, the tail, and the simple baseplate. It is noteworthy that we identified the position and structure of the tail tube initiator protein gp43 (referred to as the DNA circularization protein). The protein gp43 plays a crucial role not only in the baseplate assembly and DNA circularization but also in stabilizing the wedge-hub connection and mediating tail contraction. Except for the baseplate structure, the structural comparison of Mu in its extended and contracted states revealed that only the tail sheath protein gp39 and the C-terminus of the tail terminator protein gp37 undergo notable conformational changes to accommodate the tail contraction, whereas the remaining protein components remained unchanged. Our structures exhibited conserved properties among the majority of myophages, thereby providing valuable insights into the contraction mechanisms across myophages and contractile injection systems (CISs).

IMPORTANCE
Despite extensive study, the asymmetric structures of phage Mu, a highly effective transposable myophage, remain unknown. In this study, we present the high-resolution structures of Mu in both its extended and contracted states. The comparison of the two structures allows for the illustration of detailed conformational changes of the head-to-tail complex during the process of tail contraction. The contraction mechanism of Mu is highly conserved and widely adapted to all contractile nanomachines that share common structural features with Mu.
Rationally minimizing natural product libraries using mass spectrometry
Authors: Ness Monica , Peramuna Thilini , Wendt Karen L. , Collins Jennifer E. , King Jarrod B. , Paes Raphaella , Santos Natalia Mojica , Okeke Crystal , Miller Cameron R. , Chakrabarti Debopam , Cichewicz Robert H. , McCall Laura-Isobel 
Published: February 2025

ABSTRACT

Natural products are a critical source of novel chemotypes for drug discovery. However, the implementation of natural product extract libraries in high throughput screening is hampered by natural product structural redundancy and potential for bioactive re-discovery. This challenge and large library sizes drastically increase the time and cost during initial high throughput screens. To address these limitations, we developed a method that leverages liquid chromatography-tandem mass spectrometry spectral similarity to dramatically reduce natural product library size, with minimal bioactive loss, and applied this to a collection of fungal extracts. Importantly, this method also afforded increased bioassay hit rates against microbial targets, with broad applicability across assays and natural product sources. Thus, this method offers a broadly applicable strategy for accelerated and cost-effective natural product drug discovery.

IMPORTANCE
Natural product libraries are large collections of extracts derived from fungi, plants, bacteria, or any other natural sources. These libraries play an important role in the initial phases of drug discovery, providing the basis for bioassays against a target of interest. However, these collections often comprise thousands of extracts with sometimes overlapping chemical structures, which can result in a bottleneck in both time and costs for the initial phases of drug discovery. Here, we have developed a method that uses mass spectrometry to dramatically reduce the size of these libraries, with minimal tradeoffs and improved success rates in bioassays. Ultimately, this will speed up the process of bioactive candidate identification and isolation, and drug development overall.
Context matters: assessing the impacts of genomic background and ecology on microbial biosynthetic gene cluster evolution
Authors: Salamzade Rauf , Kalan Lindsay R. 
Published: February 2025

ABSTRACT

Encoded within many microbial genomes, biosynthetic gene clusters (BGCs) underlie the synthesis of various secondary metabolites that often mediate ecologically important functions. Several studies and bioinformatics methods developed over the past decade have advanced our understanding of both microbial pangenomes and BGC evolution. In this minireview, we first highlight challenges in broad evolutionary analysis of BGCs, including delineation of BGC boundaries and clustering of BGCs across genomes. We further summarize key findings from microbial comparative genomics studies on BGC conservation across taxa and habitats and discuss the potential fitness effects of BGCs in different settings. Afterward, recent research showing the importance of genomic context on the production of secondary metabolites and the evolution of BGCs is highlighted. These studies draw parallels to recent, broader, investigations on gene-to-gene associations within microbial pangenomes. Finally, we describe mechanisms by which microbial pangenomes and BGCs evolve, ranging from the acquisition or origination of entire BGCs to micro-evolutionary trends of individual biosynthetic genes. An outlook on how expansions in the biosynthetic capabilities of some taxa might support theories that open pangenomes are the result of adaptive evolution is also discussed. We conclude with remarks about how future work leveraging longitudinal metagenomics across diverse ecosystems is likely to significantly improve our understanding on the evolution of microbial genomes and BGCs.