bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Triptycene‐Based 2D MOF with Vertically Extended Structure for Improving the Electrocatalytic Performance of CO2 to Methane
Authors: Lv Jianning , Li Wenrui , Li Jiani , Zhu Zhejiaji , Dong Anwang , Lv Huixia , Li Pengfei , Wang Bo 
Published: January 2023

AbstractTwo‐dimensional conductive metal‐organic frameworks (2D‐c‐MOFs) have attracted extensive attention owing to their unique structures and physical‐chemical properties. However, the planarly extended structure of 2D‐c‐MOFs usually limited the accessibility of the active sites. Herein, we designed a triptycene‐based 2D vertically conductive MOF (2D‐vc‐MOF) by coordinating 2,3,6,7,14,15‐hexahydroxyltriptycene (HHTC) with Cu2+. The vertically extended 2D‐vc‐MOF(Cu) possesses a weak interlayer interaction, which leads to a facile exfoliation to the nanosheet. Compared with the classical 2D‐c‐MOFs with planarly extended 2D structures, 2D‐vc‐MOF(Cu) exhibits a 100 % increased catalytic activity in terms of turnover number and a two‐fold increased selectivity. Density functional theory (DFT) calculations further revealed that higher activity originated from the lower energy barriers of the vertically extended 2D structures during the CO2 reduction reaction process.
Scalable Green Synthesis of Robust Ultra‐Microporous Hofmann Clathrate Material with Record C3H6 Storage Density for Efficient C3H6/C3H8 Separation
Authors: Liu Di , Pei Jiyan , Zhang Xu , Gu Xiao‐Wen , Wen Hui‐Min , Chen Banglin , Qian Guodong , Li Bin 
Published: January 2023

AbstractDeveloping porous materials for C3H6/C3H8 separation faces the challenge of merging excellent separation performance with high stability and easy scalability of synthesis. Herein, we report a robust Hofmann clathrate material (ZJU‐75a), featuring high‐density strong binding sites to achieve all the above requirements. ZJU‐75a adsorbs large amount of C3H6 with a record high storage density of 0.818 g mL−1, and concurrently shows high C3H6/C3H8 selectivity (54.2) at 296 K and 1 bar. Single‐crystal structure analysis unveil that the high‐density binding sites in ZJU‐75a not only provide much stronger interactions with C3H6 but also enable the dense packing of C3H6. Breakthrough experiments on gas mixtures afford both high separation factor of 14.7 and large C3H6 uptake (2.79 mmol g−1). This material is highly stable and can be easily produced at kilogram‐scale using a green synthesis method, making it as a benchmark material to address major challenges for industrial C3H6/C3H8 separation.
Synthese und Reaktivität eines Cyclooctatetraen‐artigen Polyphosphor‐Ligandkomplexes [Cyclo‐P8]
Authors: Riesinger Christoph , Dielmann Fabian , Szlosek Robert , Virovets Alexander V. , Scheer Manfred 
Published: January 2023

AbstractDie Thermolyse von Cp′′′Ta(CO)4 mit weißem Phosphor (P4) eröffnet den Zugang zu [{Cp′′′Ta}2(μ,η2 : 2 : 2 : 2 : 1 : 1‐P8)] (A), der erste Komplex, der einen cyclooctatetraen‐artigen (COT) cyclo‐P8‐Liganden enthält. Während sich Ringgrößen von n >6 für cyclo‐Pn‐Strukturmotive bisher nicht realisieren ließen, konnte A abhängig von der Wahl des Übergangsmetalls, des Coliganden und der Reaktionsbedingungen isoliert werden. Untersuchungen zur Reaktivität zeigen sein vielseitiges Koordinationsverhalten und seine Redoxeigenschaften. Während die Oxidation zur Dimerisierung führt und [{Cp′′′Ta}4(μ4,η2 : 2 : 2 : 2 : 2 : 2 : 2 : 2 : 1 : 1 : 1 : 1‐P16)][TEF]2 (4, TEF=[Al(OC{CF3}3)4]−) ergibt, führt die Reduktion dagegen zur Spaltung einer P−P‐Bindung in A mit anschließender schneller Dimerisierung und Bildung von [K@[2.2.2]Kryptand]2[{Cp′′′Ta}4(μ4,η2 : 2 : 2 : 2 : 2 : 2 : 2 : 2 : 1 : 1 : 1 : 1‐P16)] (5), welches einen beispiellosen kettenartigen P16‐Liganden aufweist. Letztlich dient A als ein P2‐Synthon, welches über eine Ringkontraktion zum Triple‐Decker‐Komplex [{Cp′′′Ta}2(μ,η6 : 6‐P6)] (B) reagiert.
Merging Copper(I) Photoredox Catalysis and Iodine(III) Chemistry for the Oxy‐monofluoromethylation of Alkenes
Authors: Ramkumar Nagarajan , Baumane Larisa , Zacs Dzintars , Veliks Janis 
Published: January 2023

AbstractA simple process for the oxy‐monofluoromethylation of alkenes is described. In combination with visible‐light copper(I) photoredox catalysis, an easily accessible iodine(III) reagent containing monofluoroacetoxy ligands serves as a powerful source of a monofluoromethyl (CH2F) radical, enabling the step economical synthesis of γ‐fluoro‐acetates from a broad range of olefinic substrates under mild conditions. Applications to late‐stage diversification of alkenes derived from complex molecules, amino acids and the synthesis of fluoromethylated heterocycles are also demonstrated.
Excited State Mixed‐Valence Complexes: From the Special Pair to the Creutz–Taube Ion and Beyond
Authors: Low Paul J. 
Published: January 2023

AbstractCompounds and complexes with mixed‐valence electronic ground states, such as the Creutz–Taube ion, have proven to be excellent vehicles through which to study intramolecular electron‐transfer processes. In a recent contribution by Cadranel and co‐workers, time‐resolved pump‐probe spectroscopy reveals photo‐induced metal‐to‐bridge charge transfer within the homovalent analogue of the Creutz–Taube ion, [{(NH3)5Ru}(μ‐pz){Ru(NH3)5}]4+, giving rise to two closely lying excited states with mixed‐valence character, one with a shorter lifetime (τ=136 ps) and weakly‐coupled (Robin‐Day Class II) character, the other a longer‐lived (τ=2.8 ns) configurational isomer with more delocalized electronic structure. Electron transfer reactions from the longer‐lived species demonstrate analogies with the photo‐induced reactions of the photosynthetic special pair, suggesting this state as a reference system for excited state mixed‐valency, and a framework from which to explore photocatalytic reactions.
Structural Fusion Yields Guest Acceptors that Enable Ternary Organic Solar Cells with 18.77 % Efficiency
Authors: Meng Fei , Qin Ying , Zheng Yiting , Zhao Zhihan , Sun Yanna , Yang Yingguo , Gao Ke , Zhao Dongbing 
Published: January 2023

AbstractThe design and selection of a suitable guest acceptor are particularly important for improving the photovoltaic performance of ternary organic solar cells (OSCs). Herein, we designed and successfully synthesized two asymmetric silicon–oxygen bridged guest acceptors, which featured distinct blue‐shifted absorption, upshifted lowest unoccupied molecular orbital energy levels, and larger dipole moments than symmetric silicon–oxygen‐bridged acceptor. Ternary devices with the incorporation of 14.2 wt % these two asymmetric guest acceptors exhibited excellent performance with power conversion efficiencies (PCEs) of 18.22 % and 18.77 %, respectively. Our success in precise control of material properties via structural fusion of five‐membered carbon linkages and six‐membered silicon–oxygen connection at the central electron‐donating core unit of fused‐ring electron acceptors can attract considerable attention and bring new vigor and vitality for developing new materials toward more efficient OSCs.
Ultra‐Fast Preparation of Large‐Area Graphdiyne‐Based Membranes via Alkynylated Surface‐Modification for Nanofiltration
Authors: Yang Xingda , Qu Zhou , Li Sen , Peng Manhua , Li Chunxi , Hua Ruimao , Fan Hongwei , Caro Jürgen , Meng Hong 
Published: January 2023

AbstractGraphdiynes (GDYs), two‐dimensional graphene‐like carbon systems, are considered as potential advanced membrane material due to their unique physicochemical features. Nevertheless, the scale‐up of integrated GDY membranes is technologically challenging, and most studies remain at the theoretical stage. Herein, we report a simple and efficient alkynylated surface‐mediated strategy to prepare hydrogen‐substituted graphdiyne (HsGDY) membranes on commercial alumina tubes. Surface alkynylation initiates an accelerated surface‐confined coupling reaction in the presence of a copper catalyst and facilitates the nanoscale epitaxial lateral growth of HsGDY. A continuous and ultra‐thin HsGDY membrane (∼100 nm) can be produced within 15 min. The resulting membranes exhibit outstanding molecular sieving together with excellent water permeances (ca. 1100 L m−2 h−1 MPa−1), and show a long‐term durability in cross‐flow nanofiltration, owing to the superhydrophilic surface and hydrophobic pore walls.
Water‐Driven Synthesis of Deep‐Blue Perovskite Colloidal Quantum Wells for Electroluminescent Devices
Authors: Zhang Mengqi , Bi Chenghao , Xia Yuexing , Sun Xuejiao , Wang Xingyu , Liu Aqiang , Tian Shuyu , Liu Xinfeng , de Leeuw Nora H. , Tian Jianjun 
Published: January 2023

AbstractPerovskite colloidal quantum wells (QWs) are promising to realize narrow deep‐blue emission, but the poor optical performance and stability suppress their practical application. Here, we creatively propose a water‐driven synthesis strategy to obtain size‐homogenized and strongly confined deep‐blue CsPbBr3 QWs, corresponding to three monolayers, which emit at the deep‐blue wavelength of 456 nm. The water controls the orientation and distribution of the ligands on the surface of the nanocrystals, thus inducing orientated growth through the Ostwald ripening process by phagocytizing unstable nanocrystals to form well‐crystallized QWs. These QWs present remarkable stability and high photoluminescence quantum yield of 94 %. Furthermore, we have prepared light‐emitting diodes based on the QWs via the all‐solution fabrication strategy, achieving an external quantum efficiency of 1 % and luminance of 2946 cd m−2, demonstrating state‐of‐the‐art brightness for perovskite QW‐based LEDs.
Crosslinked polymers based on monomers derived from renewable resources and their application potential
Authors: Strehmel Veronika , Strehmel Bernd 
Published: January 2023

AbstractPossible structural variation of a bio‐based dimethacrylate derived from oleic acid and ethylene glycol is discussed as well as sources to obtain the starting material for manufacturing this monomer. Introduction of an aromatic structure either as a bridge between the two ester structures formed or as a substituent is expected to influence the properties of both the monomer and polymer made of it, for example, by photoinitiated polymerization. Furthermore, aspects influencing the transfer of a new product are included in the discussion as well to increase the interest of researchers working in the industry on manufacturing a new product and its development for the market.
Development of a Magnetic Resonance Imaging–Based Definition of Knee Osteoarthritis: Data From the Multicenter Osteoarthritis Study
Authors: Liew Jean W. , Rabasa Gabriela , LaValley Michael , Collins Jamie , Stefanik Joshua , Roemer Frank W. , Guermazi Ali , Lewis Cora E. , Nevitt Michael , Torner James , Felson David 
Published: January 2023

ObjectiveAlthough magnetic resonance imaging (MRI) is the imaging modality of choice for research, there is no widely accepted MRI definition of knee osteoarthritis (OA). We undertook this study to test the performance of different MRI definitions of OA.MethodsWe studied Multicenter Osteoarthritis Study participants with knee symptoms using posteroanterior and lateral knee radiographs and MRIs. Radiographic OA was defined as Kellgren/Lawrence grade ≥2 in the tibiofemoral (TF) and/or patellofemoral (PF) joint. Symptomatic OA was defined using a validated questionnaire. MRI findings of cartilage damage, osteophytes, bone marrow lesions (BMLs), and synovitis were scored using the Whole‐Organ MRI Score system. We compared definitions using combinations of MRI features to the validation criteria of prevalent radiographic OA and symptomatic OA. All combinations included cartilage damage score ≥2 (0–6 scale) and osteophyte score ≥2 (0–6 scale); addition of BMLs and synovitis score was also tested. We also evaluated a Delphi panel definition that defined OA differently for the PF and TF joints. For each definition, we calculated sensitivity, specificity, and the area under the curve (AUC).ResultsWe included 1,185 knees from 1,185 participants (mean age 66 years, 62% female, 89% White). Among the 1,185 knees, 482 knees had radiographic OA, and 524 knees had symptomatic OA. The MRI definitions with a cartilage score ≥2 and osteophyte score ≥2 and definitions which added BMLs or synovitis score ≥1 had the highest sensitivities (95.2% and 94.5%, respectively) for prevalent radiographic OA (AUCs 0.67 and 0.69, respectively), and also had the highest sensitivities for symptomatic OA. The Delphi panel definition had similar performance but was more complex to apply.ConclusionAn MRI OA definition requiring cartilage damage and a small osteophyte with or without BMLs or synovitis had the best performance and was simplest for identifying radiographic OA and symptomatic OA.
Structural differences in the cortex of individuals who experience the autonomous sensory meridian response
Authors: Kornelsen Jennifer , Fredborg Beverley K. , Smith Stephen D. 
Published: January 2023

AbstractBackground and purposeThe autonomous sensory meridian response (ASMR) is a multimodal perceptual phenomenon in which specific sensory triggers evoke tingling sensations on the scalp, neck, and shoulders; these sensations are accompanied by a positive and calming affective state. Previous functional neuroimaging research has shown that ASMR experiences involve medial prefrontal and sensorimotor brain areas. The purpose of the current study was to examine whether there are structural differences in the cortex of individuals who experience ASMR.MethodsSeventeen individuals with ASMR and 17 matched control participants completed an MPRAGE structural MRI scan. These data were analyzed to determine if group differences were present for measures of cortical thickness, cortical complexity, sulcal depth, and gyrification.ResultsASMR was associated with reduced cortical thickness in a number of regions including the left precuneus, precentral gyrus, and insula, and the right orbitofrontal cortex, superior frontal cortex, and paracentral lobule. Reduced thickness was observed bilaterally in the supramarginal gyrus. Individuals with ASMR also showed less cortical complexity in the pars opercularis and pars triangularis.ConclusionsThe differences in cortical thickness and complexity were in brain areas whose functions relate to the ASMR experience. These differences include neural regions related to phonological processing, sensorimotor functions, and attention.
Application of organoid culture from HPV18‐positive small cell carcinoma of the uterine cervix for precision medicine
Authors: Kusakabe Misako , Taguchi Ayumi , Tanikawa Michihiro , Hoshi Daisuke , Tsuchimochi Saki , Qian Xi , Toyohara Yusuke , Kawata Akira , Wagatsuma Ryota , Yamaguchi Kohei , Yamamoto Yoko , Ikemura Masako , Sone Kenbun , Mori‐Uchino Mayuyo , Matsunaga Hiroko , Tsuruga Tetsushi , Nagamatsu Takeshi , Kukimoto Iwao , Wada‐Hiraike Osamu , Kawazu Masahito , Ushiku Tetsuo , Takeyama Haruko , Oda Katsutoshi , Kawana Kei , Hippo Yoshitaka , Osuga Yutaka 
Published: January 2023

AbstractBackgroundSmall cell carcinoma of the uterine cervix (SCCC) is a rare and highly malignant human papillomavirus (HPV)‐associated cancer in which human genes related to the integration site can serve as a target for precision medicine. The aim of our study was to establish a workflow for precision medicine of HPV‐associated cancer using patient‐derived organoid.MethodsOrganoid was established from the biopsy of a patient diagnosed with HPV18‐positive SCCC. Therapeutic targets were identified by whole exome sequencing (WES) and RNA‐seq analysis. Drug sensitivity testing was performed using organoids and organoid‐derived mouse xenograft model.ResultsWES revealed that both the original tumor and organoid had 19 somatic variants in common, including the KRAS p.G12D pathogenic variant. Meanwhile, RNA‐seq revealed that HPV18 was integrated into chromosome 8 at 8q24.21 with increased expression of the proto‐oncogene MYC. Drug sensitivity testing revealed that a KRAS pathway inhibitor exerted strong anti‐cancer effects on the SCCC organoid compared to a MYC inhibitor, which were also confirmed in the xenograft model.ConclusionIn this study, we confirmed two strategies for identifying therapeutic targets of HPV‐derived SCCC, WES for identifying pathogenic variants and RNA sequencing for identifying HPV integration sites. Organoid culture is an effective tool for unveiling the oncogenic process of rare tumors and can be a breakthrough for the development of precision medicine for patients with HPV‐positive SCCC.
Cancer cell‐derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma
Authors: Wenhua Shao , Tsunematsu Takaaki , Umeda Masaaki , Tawara Hiroaki , Fujiwara Natsumi , Mouri Yasuhiro , Arakaki Rieko , Ishimaru Naozumi , Kudo Yasusei 
Published: January 2023

AbstractIt recently has been reported that partial‐epithelial–mesenchymal transition (p‐EMT) program is associated with metastasis in head and neck squamous cell carcinoma (HNSCC). We previously have identified POSTN (which encodes periostin) as an invasion‐promoting molecule in HNSCC. Interestingly, POSTN expression is frequently observed in cancer cells with higher p‐EMT score by using a previous single‐cell transcriptomic data of HNSCC cases. Although it is known that POSTN has 11 splicing variants, the role of them has not been determined in HNSCC. Here, we found that HNSCC cells with EMT features expressed POSTN isoforms, Iso3 (lacking exon 17 and 21) and Iso5 (lacking exon 17), whereas fibroblast expressed Iso3 and Iso4 (lacking exon 17, 18, and 21). The expression of POSTN Iso3 and Iso4 are known to be widely observed in various cell types including stromal cells. Therefore, we focused on the role of novel cancer cell‐derived POSTN isoform, Iso5, in HNSCC. Single overexpression of POSTN Iso5 as well as Iso3 promoted invasion. Surprisingly, Iso5 synergistically promoted invasion together with Iso3. Notably, Iso5 as well as Iso3 upregulated p‐EMT‐related genes. We suggest that a novel cancer‐specific POSTN isoform lacking exon 17 (Iso5) can be a useful marker for detecting cancer cells undergoing p‐EMT. Moreover, a POSTN Iso5 can be a novel target for diagnosis and therapy in HNSCC.
Robots make no effort! Service evaluation and consumer mindset
Authors: Nie Xinyu , Huang Jingya 
Published: January 2023

AbstractConsidering the growing acceptance of humanoid robots in the service industry, this study aimed to examine their negative impact on service evaluation, as well as the underlying mechanism of perceived effort and the moderating role of consumer mindset. Three experiments that used different service scenarios revealed that humanoid service robots negatively affected service evaluation compared to human employees, and this effect was mediated by decreased perceived effort. Furthermore, this negative impact was attenuated when consumers had a concrete mindset compared to abstract. This work contributes to both consumer service and robot literature by elaborating on the possible adverse influence of replacing human employees with humanoid service robots. It also offers managerial implications for how and when to adopt a robot service in this machine age.
Antiproliferative Noscapinoids Bearing an Amidothiadiazole Scaffold as Apoptosis Inducers: Design, Synthesis and Molecular Docking
Authors: Kumar Pedapati Ravi , Pragyandipta Pratyush , Pranathi Abburi Naga , Chirra Nagaraju , Kantevari Srinivas , Naik Pradeep K. 
Published: January 2023

AbstractNoscapine an FDA‐approved antitussive agent. With low cytotoxicity with higher concentrations, noscapine and its derivatives have been shown to have exceptional anticancer properties against a variety of cancer cell lines. In order to increase its potency, in this study, we synthesized a series of new amido‐thiadiazol coupled noscapinoids and tested their cytotoxicity in vitro. All of the newly synthesised compounds demonstrated potent cytotoxic potential, with IC50 values ranging from 2.1 to 61.2 μM than the lead molecule, noscapine (IC50 value ranges from 31 to 65.5 μM) across all cell lines, without affecting normal cells (IC50 value is>300 μM). Molecular docking of all these molecules with tubulin (PDB ID: 6Y6D, resolution 2.20 Å) also revealed better binding affinity (docking score range from −5.418 to −9.679 kcal/mol) compared to noscapine (docking score is −5.304 kcal/mol). One of the most promising synthetic derivatives 6aa (IC50 value ranges from 2.5 to 7.3 μM) was found to bind tubulin with the highest binding affinity (ΔGbinding is −28.97 kcal/mol) and induced apoptosis in cancer cells more effectively.
Chemical Constituents of the Branches and Leaves of Picrasma chinensis P.Y. Chen and Tyrosinase Inhibiting Activity
Authors: Zhou Qin‐Tao , Yang Peng‐Yun , Yang Quan‐Yu , Pang Wen‐Hui , Li Xiao‐Li , Zhang Xing‐Jie , Zhang Rui‐Han , Xiao Wei‐Lie 
Published: January 2023

AbstractOne new alkaloid, picrasine A, two new quassinoids, picralactones A−B, together with eleven known compounds were isolated from Picrasma chinensis P.Y. Chen. The structures of these compounds were determined using 1D and 2D NMR, HR‐ESI‐MS, and IR spectroscopic data, and by comparison with published data. Some compounds were tested for tyrosinase inhibiting activity, however, none of them exhibited strong inhibitory effects.
Percutaneous treatment of multiple fistulas associated with a giant aneurysm
Authors: Vera‐Vera Silvio , Jurado‐Roman Alfonso , Moreno Raúl , Galeote Guillermo 
Published: January 2023

AbstractCoronary fistulas are not common in patients undergo coronary angiography. It is described, even less frequently, that coronary fistulas may be associated with giant aneurysms along their course. These cases classically are treated surgically. We present a case treated fully percutaneously in a novel fashion.
Imaging manifestations of small cell neuroendocrine carcinoma of the ureter
Authors: Chen Guiwu , Huang Xiong , Liu Wenqin , Liao Xiaomin , He Zhizhong , Xie Yuhuan 
Published: January 2023

AbstractSmall cell neuroendocrine carcinoma (SCNEC) of the ureter is a rare malignant tumor originating from the metaplasia of urothelial cells. This report presents a case of ureteral SCNEC that was preliminarily disclosed by computed tomography; thereafter, transabdominal ultrasonography, transrectal ultrasonography, and magnetic resonance urography were performed to characterize the mass.
A case of dysautonomia after COVID‐19 infection in a patient with poorly controlled type I diabetes
Authors: Aitkens Lorry , Downey George 
Published: January 2023

AbstractCOVID‐19 has been linked to dysautonomia in the current literature, as has uncontrolled diabetes. Here, we present a case report of severe dysautonomia following a COVID‐19 infection in a patient with pre‐existing poorly controlled type‐1 diabetes. This patient exhibited symptoms consistent with both postural orthostatic tachycardia syndrome (POTS), as well as orthostatic hypotension. His symptoms became so severe that he was unable to come to a standing position without experiencing syncope. Extensive workup was completed to identify an alternative cause of his dysautonomia with inconclusive results. Dysautonomia can have devastating consequences in regard to physical, social, and psychological health. Counseling individuals with poorly controlled diabetes about the importance of maintaining tight blood glucose control and avoiding COVID‐19 infection should be primary interventions when treating patients with this DM1. Early detection and management of diabetes mellitus, COVID‐19, and of possible resultant dysautonomia through medical interventions, as well as lifestyle changes, are extremely important measures to avoid development of dangerous and potentially life‐threatening consequences.