bluuebunny/crossref_metadata_2025_split huggingface dataset:
O Direito do Trabalho diante da iminência do fim do mundo
Authors: Severo Valdete 
Published: January 2025

Introdução: O artigo busca promover uma reflexão sobre a importância da efetividade dos direitos trabalhistas.
Objetivo: O objetivo é provocar uma reflexão acerca da função que o Direito do Trabalho tem a exercer, diante da precipitação de emergências climáticas, que revelam o esgotamento de um modelo de sociabilidade específico.
Metodologia: A metodologia será materialista histórica, pois articulará pensamentos de autoras e autores que se filiam a uma visão crítica do capitalismo, partindo de Marx como principal referencial teórico.
Resultados: O estudo evidencia que a questão social é exatamente o que provoca o Estado, não sem resistências, a admitir a necessidade de acolher algumas demandas de cuidado, através do Direito. No discurso do Direito do Trabalho, o Estado reconhece a necessidade de proteção e cria mecanismos não apenas de contenção, mas também de tensionamento e transgressão da lógica capitalista. Ao estabelecer limites à jornada e ao salário ou impor condições saudáveis de trabalho, reconhece-se a necessidade de cuidar das pessoas, para que elas consigam viver sob a lógica do trabalho obrigatório, sem adoecer ou morrer precocemente.
Conclusão: A conclusão é de que a efetividade dos direitos trabalhistas é um caminho para a construção de discursos ainda mais transformadores, que permitam outras formas de conviver com a natureza e com os demais seres, de modo saudável e harmonioso.
PALAVRAS-CHAVE: cuidados; direito do trabalho; ecossocialismo; emergência climática; vida.
Pengaruh Peran Transportasi, Partisipasi Masyarakat Dalam Pengembangan Wisata Danau Sidihoni Terhadap Peningkatan Kepuasan Wisatawan
Authors: SIREGAR MIRA YOSEFA 
Published: January 2025

Pulau Samosir berada persis di Danau Toba yang merupakan danau vulkanik terbesar di dunia. Pemandangan alam yang memukau, sejuk dan mempunyai daya tarik karena berada di tengah Danau Toba Sumatera Utara, Danau Sidihoni terletak di Desa Salaon Toba, Kecamatan Ronggur Ni Huta ini awalnya merupakan kawasan hutan dan rawa seiring waktu wilayah tersebut berubah menjadi cekungan yang terisi air hingga menjadi danau, danau ini bisa berubah warna yang disebabkan oleh ragam fenomena lingkungan. Danau ini dikelilingi bukit landai berbentuk seperti mangkok. Minimnya transportasi umum menuju akses wisata danau si dihoni merupakan salah satu faktor bahwa masih kurangnya pengunjung wisatawan karena daerahnya yang lumayan jauh dari Tomok Kecamatan Simanindo sekitar 2 jam, dari Pangururan menuju ke Danau Sidihoni sekitar 30 Menit sekitar 9 km. Kegiatan ini dilakukan untuk memberikan informasi dan wawasan dalam mengembangkan promosi kajian destinasi alam wisata danau sidihoni serta meningkatkan partisipasi masyarakat dalam meningkatkan pendapatan di daerah objek wisata danau sidihoni. Dalam penelitian ini data dikumpulkan melalui observasi, wawancara dan dokumentasi terhadap 53 informan pada waktu liburan natal dan tahun baru Tahum 2024 dengan menggunakan teknik snowball sampling dengan metode deskriptif kualitatif. Hasil Menunjukkan bahwa pada Bulan Desember Tahun 2024 dengan probabilitas 0,000<0,05 dengan Fhitung Sebesar 22,070 dan Ftabel 3.19 menyatakan ada pengaruh yang positif dan signifikan antara peran transportasi, partisipasi masyarakat dalam pengembangan wisata danau sidihoni terhadap kepuasan wisatawan. Pentingnya moda darat angkutan umum trayek Danau Sidihoni dari Tomok dan Pangururan guna meningkatkan jumlah wisatawan yang ingin menikmati suasana sejuk dan pemandangan yang indah saat berliburan.
Comparative Analysis of Concrete and Reinforcement Work Volume Using Building Information Modelling Support Software
Authors: Hasbi Edlin Al Khuzaifah , Susanti Betty , Adhitya Bimo Brata 
Published: January 2025

The era of the 4.0 revolution has four principles consisting of interconnection, information transparency, technical assistance, and decentralized decision-making. Four principles can be the guidelines for the Building Information Modelling (BIM) system. Government building projects have rules that stipulate that the BIM system must be applied in every construction project. The purpose of this study is to compare the volume of plan and realization work from contractors with conventional methods with plan and realization modeling on pilecap, column, and beam work for concrete and reinforcing work. The method used in this study is to make concrete and reinforcing modeling using Glodon Cubicost TAS and TRB software and use comparative analysis for each work volume result from conventional calculations and BIM modeling results. The data needed consists of general building data, plan drawing data and realization, as well as calculation of the volume of concrete and reinforcement. The results of the study show that there is a varied percentage difference between the data from the contractor and the modeling made, both plans and realization. The use of this software is considered effective if it has been used since the beginning of the construction project, because it can reduce errors and improve the integration between RAB and plan drawings as well as RAP and As Built Drawing.
Faktor Lingkungan yang Berhubungan dengan Kejadian Malaria di Kabupaten Kepulauan Mentawai
Authors: Rizki Noura , Masrizal Masrizal , Haq Arinil , Siswati Sri 
Published: January 2025

Malaria merupakan penyakit menular di wilayah beriklim tropis. API Kabupaten Kepulauan Mentawai yang merupakan wilayah endemis malaria pada tahun 2022 sebesar 1,46 per 1000 penduduk. Penelitian ini bertujuan untuk mengetahui hubungan antara faktor lingkungan dengan kejadian Malaria di Kabupaten Kepulauan Mentawai tahun 2018-2022. Penelitian ini menggunakan rancangan studi ekologi. Sampel dalam penelitian ini adalah seluruh kejadian malaria yang tercatat di Dinas Kesehatan Kabupaten Kepulauan Mentawai dan data unsur iklim di BMKG Meteorologi Minangkabau dan BMKG Klimatologi Sicincin, data mobilitas di Dinas Perhubungan Kabupaten Kepulauan Mentawai serta data kemiskinan di Dinas Sosial Kabupaten Kepulauan Mentawai tahun 2018-2022. Metode analisis adalah analisis univariat dan bivariat menggunakan uji korelasi. Hasil penelitian menunjukkan kejadian malaria mengalami peningkatan setiap bulan Juni hingga Agustus. Hasil analisis kejadian malaria dengan unsur iklim dan faktor lingkungan sosial yaitu temperatur (p=0,009; r=-0,332), curah hujan (p=0,001; r=0,513), kecepatan angin (p=0,283; r=0,141), kelembaban (p=0,566; r=0,076), mobilitas (p=0,127; r=0,199), kemiskinan (p=0,899; r=0,018) dan kepadatan penduduk (p=0,028; r=0,311). Kesimpulan dari penelitian ini adanya hubungan bermakna antara temperatur, curah hujan dan kepadatan penduduk terhadap kejadian penyakit Malaria. Disarankan untuk meningkatkan tindakan preventif yaitu membersihkan lingkungan dan memberantas breeding places serta edukasi kesehatan kepada masyarakat pada bulan Juni hingga Agustus.
Color fundus photograph-based diabetic retinopathy grading via label relaxed collaborative learning on deep features and radiomics features
Authors: Zhang Chao , Sheng Guanglei , Su Jie , Duan Lian 
Published: January 2025

IntroductionDiabetic retinopathy (DR) has long been recognized as a common complication of diabetes, making accurate automated grading of its severity essential. Color fundus photographs play a crucial role in the grading of DR. With the advancement of artificial intelligence technologies, numerous researchers have conducted studies on DR grading based on deep features and radiomic features extracted from color fundus photographs.MethodWe combine deep features and radiomic features to design a feature fusion algorithm. First, we utilize convolutional neural networks to extract deep features from color fundus photographs and employ radiomic methodologies to extract radiomic features. Subsequently, we design a label relaxation-based collaborative learning algorithm for feature fusion.ResultsWe validate the effectiveness of the proposed method on two fundus image datasets: the DR1 Dataset and the MESSIDOR Dataset. The proposed method achieved 96.86 of AUC on DR1 and 96.34 of AUC on MESSIDOR, which are better than state-of-the-art methods. Also, the divergence between the training AUC and testing AUC increases substantially after the removal of manifold regularization.ConclusionLabel relaxation can enhance the distinguishability of training samples in the label space, thereby improving the model's classification accuracy. Additionally, graph constraints based on manifold learning methods can mitigate overfitting caused by label relaxation.
Enhanced recovery in type A aortic dissection evaluating the efficacy and feasibility of early myocardial reperfusion
Authors: Niu Tianyu , Liu Zhishuo , Liu Yu , Yang Zhonglu , Ge Yuguang , Wang Lu , Xia Lin , Jiang Hui 
Published: January 2025

BackgroundThis study investigates the feasibility and early outcomes of early myocardial reperfusion in patients with type A aortic dissection (TAAD), evaluating its effectiveness and potential benefits compared to traditional cardioplegic arrest techniques.MethodsA retrospective analysis was conducted on 168 patients diagnosed with TAAD who underwent surgery at the General Hospital of the Northern Theater Command in China from January 2021 to July 2024. Patients were divided into two groups: early myocardial reperfusion (EMR group, n = 66) and cardioplegic arrest (CA group, n = 102). Perioperative outcomes were compared between the groups.ResultsEarly myocardial reperfusion significantly reduced ventilation time 23.08 (18.21, 66.74) hours vs. 48.58 (19.18, 122.97) hours, P &lt; 0.05], ICU stay time [58.80 (21.20, 126.68) hours vs. 84.86 (41.12, 168.81) hours, P &lt; 0.05], and hospitalization time [13.00 (10.00, 16.00) days vs. 15.00 (11.75, 19.00) days, P &lt; 0.05] compared to the CA group. There was no significant difference in hospital costs, first-hour chest tube drainage, left ventricular ejection fraction, or postoperative adverse events between the groups, except for the rate of CRRT treatment, where the EMR group had significantly fewer patients requiring postoperative CRRT (10.6% vs. 23.5%, P &lt; 0.05).ConclusionThis study demonstrates that early myocardial reperfusion is a feasible and effective technique for TAAD, offering considerable advantages in reducing ventilation time, ICU stay, hospitalization duration and postoperative renal insufficiency.
Teacher professional learning communities and children’s school readiness in China: the moderating role of supportive conditions and cooperative atmosphere
Authors: Ren Jie , Mo Yunjuan , Zhang Yulong , Hou Yuna 
Published: January 2025

IntroductionThis study examined whether teacher professional learning communities (PLCs) established through a collaborative effort between kindergarten and primary school teachers can effectively promote Chinese children’s school readiness and explore the policy conditions that stimulate such a facilitative effect.MethodsA total of 839 children and 67 teachers in kindergartens from Chongqing, China, participated in this study. Firstly, we used descriptive statistical analysis to determine the overall situation of teacher PLCs. Subsequently, a series of mean difference tests and multiple linear regression analysis were used to test the relationship between teacher PLCs and children’s school readniess.ResultsThe results indicated that the three dimensions of teacher PLCs, including shared vision, collaborative practice, and resource sharing, significantly and positively predicted children’s school readiness. Chinese teachers scored highest in the dimension of shared vision, followed by collaborative practice, and lowest in resource sharing. The collaborative atmosphere of teacher PLCs enhanced their effects on children’s school readiness, while the supportive conditions of teacher PLCs were ineffective.DiscussionThe empirical findings from this study broaden the scope of existing research on teacher PLCs and provide information from a Chinese context about improving children’s early development to benefit international society.
Impact of the initiation of isCGM soon after type 1 diabetes mellitus diagnosis in adults on glycemic indices and fear of hypoglycemia: a randomized controlled trial
Authors: Hohendorff Jerzy , Grzelka-Wozniak Agata , Wrobel Marta , Kania Michal , Lapinska Lidia , Rokicka Dominika , Stoltny Dorota , Kowalska Irina , Strojek Krzysztof , Zozulinska-Ziolkiewicz Dorota , Malecki Maciej T. 
Published: January 2025

BackgroundContinuous glucose monitoring (CGM) improves glycemic control and quality of life. Data on glycemic indices and fear of hypoglycemia (FoH) in newly diagnosed T1DM patients are limited.AimTo assess the impact of initiating intermittently scanned CGM (isCGM) within 1–6 months of diagnosis on glycemic control and FoH in adults with T1DM.Subjects and methodsAfter wearing a blinded sensor for 14 days, participants were randomized (1:1) to either isCGM (intervention) or self-monitoring blood glucose (SMBG) with glucometers and blinded CGM (control). Primary outcomes were changes in time below 70 mg/dl (TB70) and FoH, assessed in the Hypoglycemia Fear Survey (HFS). Main secondary outcomes included changes in mean glucose and time in range (TIR) from baseline to 4 weeks after randomization.ResultsThe full analysis set included 23 patients (12 from the intervention group and 11 from the control group), aged 25.6 ± 5.1 years (14 men, 9 women). All participants were on multiple daily insulin injections. TB70 changed from 2.42% to 2.25% in the intervention, and from 2.81% to 1.82% in the control group, and the between-therapy difference of 0.83% was insignificant. No difference between intervention and control groups in change in HFS-worry and HFS-behavior subscales between baseline and after 4 weeks was found (−1.6 ± 3.2 and 1.0 ± 2.2, respectively). The mean glucose levels changed from 7.03 mmol/l to 6.73 mmol/l and from 7.07 mmol/l to 7.43 mmol/l, in the intervention and control groups, respectively, which resulted in a between-therapy significant glucose difference of −0.66 mmol/l. The mean TIR changed from 88.0% to 90.0% in the intervention group and from 85.2 to 84.1% in the control group—the between-therapy difference was insignificant (3,1%). The study ended early due to CGM reimbursement policy changes, after which most patients eligible for the study could have isCGM reimbursed.ConclusionsIn newly diagnosed T1DM adults, TIR is high and hypoglycemia risk is low. The study group was small; however, the data suggest that the use of isCGM soon after T1DM diagnosis could result in mean glucose decrease, but not in change in TB70 and FoH.
HMGB1 lactylation drives neutrophil extracellular trap formation in lactate-induced acute kidney injury
Authors: Zhu Li , Zheng Qiang , Liu Xiaodong , Ding Hao , Ma Mengqing , Bao Jiaxin , Cai Yawen , Cao Changchun 
Published: January 2025

RationaleAcute kidney injury (AKI) is a clinical syndrome associated with a multitude of conditions. Although renal replacement therapy (RRT) remains the cornerstone of treatment for advanced AKI, its implementation can potentially pose risks and may not be readily accessible across all healthcare settings and regions. Elevated lactate levels are implicated in sepsis-induced AKI; however, it remains unclear whether increased lactate directly induces AKI or elucidates the underlying mechanisms.MethodsFor human, the measurement of lactate in arterial blood gas is performed using the direct determination of L-lactate through an electrode oxidation method by a blood gas analyzer. For mice, enzyme-linked immunosorbent assay (ELISA) kits were employed to quantify the concentrations of lactate and AKI biomarkers in blood and cell supernatant. The mouse model of AKI was performed with a single intraperitoneal (i.p.) administration of lactate (30 mg/kg) and low-dose LPS (2 mg/kg) for 24 h. Proteomic analysis was conducted to identify lactylated proteins in kidney tissues. Techniques such as, immunoprecipitation, western blotting and immunofluorescence were used to evaluate the levels of HMGB1 lactylation, neutrophil extracellular traps (NETs)and to assess related molecular signaling pathways.Main resultsOur findings indicate that lactate serves as an independent predictor of AKI in patients with acute decompensated heart failure (ADHF). We observed that co-administration of lactate with low-dose lipopolysaccharide (LPS) resulted in lactate overproduction, which subsequently elevated serum levels of creatinine (Cre) and blood urea nitrogen (BUN). Furthermore, the combined application of lactate and low-dose LPS was shown to provoke HMGB1 lactylation within renal tissues. Notably, pretreatment with HMGB1 small interfering RNA (siRNA) effectively diminished lactate-mediated HMGB1 lactylation and alleviated the severity of AKI. Additionally, lactate accumulation was found to enhance the expression levels of NETs in the bloodstream, with circulating NETs levels positively correlating with HMGB1 lactylation. Importantly, pre-administration of HMGB1 inhibitors (glycyrrhizin) or lactate dehydrogenase A (LDH-A) inhibitors (oxamate) reversed the upregulation of NETs induced by lactate and low-dose LPS in both the blood and polymorphonuclear neutrophils (PMNs) cell supernatant, thereby ameliorating AKI associated with lactate accumulation.ConclusionsThese findings illuminate the role of lactate-mediated HMGB1 lactylation in inducing AKI in mice through the activation of the HMGB1-NETs signaling pathway.
Eosinophil is a predictor of severe immune-related adverse events induced by ipilimumab plus nivolumab therapy in patients with renal cell carcinoma: a retrospective multicenter cohort study
Authors: Tasaki Yoshihiko , Hamamoto Shuzo , Yamashita Shimpei , Furukawa Junya , Fujita Kazutoshi , Tomida Ryotaro , Miyake Makito , Ito Noriyuki , Iwamoto Hideto , Mimura Yoshihisa , Sugiyama Yosuke , Unno Rei , Okada Atsushi , Yasui Takahiro , Furukawa-Hibi Yoko 
Published: January 2025

IntroductionImmune-related adverse events (irAEs) induced by immune checkpoint inhibitors are difficult to predict and can lead to severe events. Although it is important to develop strategies for the early detection of severe irAEs, there is a lack of evidence on irAEs associated with ipilimumab plus nivolumab therapy for metastatic renal cell carcinoma (RCC). Therefore, this study aimed to investigate the association between eosinophil and severe irAEs in patients receiving ipilimumab plus nivolumab therapy for RCC.MethodsIn this retrospective study, 161 patients receiving ipilimumab plus nivolumab therapy for RCC were divided into three groups based on whether they experienced &lt;grade 2 irAEs (non-severe irAE group), ≥grade 3 irAEs (severe irAE group), or not (non-irAE group). We examined the proportion of eosinophils before and 2 weeks after treatment (baseline and 2-week samples, respectively).ResultsAlthough the eosinophil in the baseline samples did not differ between the severe irAE and non-irAE groups (2.8% vs. 2.5%, P = 0.75), regarding the 2-week samples, the eosinophil was significantly higher in the severe irAE group (mean, 6.6% vs. 3.3%; P &lt; 0.05). Multivariate analysis showed that an eosinophil of ≥3.0% was a risk factor for severe irAEs (odds ratio, 6.01). Median progression-free survival (mPFS), mPFS from the start of ipilimumab plus nivolumab therapy to second-line therapy (mPFS2), and median overall survival (mOS) were the shortest in the non-irAE group. Although the mPFS did not differ between the severe and non-severe irAE groups (9.2 vs 14.2 months, P = 0.45), notably, mPFS2 and mOS in the former group tended to be shorter than those in the latter group (mPFS2: 29.2 vs not reached, P = 0.10; mOS: 36.9 vs 52.3 months, P = 0.06).DiscussionAn increased eosinophil 2 weeks after ipilimumab plus nivolumab therapy may be a predictor of severe irAEs, which are associated with poor prognoses, compared with non-severe irAEs among patients with RCC. We provide a novel rationale for the importance of monitoring eosinophil counts for the early detection of severe irAEs.
Integrated single-cell and bulk transcriptome analysis of R-loop score-based signature with regard to immune microenvironment, lipid metabolism and prognosis in HCC
Authors: Chen Long , Yang Houzhi , Wei Xianfu , Liu Jianchao , Han Xiuxin , Zhang Chao , Liu Yongheng , Zhang Yan , Xu Yao , Li Yiqin , Wang Guowen , Feng Jinyan 
Published: January 2025

BackgroundHepatocellular carcinoma (HCC) is one of the most prevalent causes of cancer-related morbidity and mortality worldwide. Late-stage detection and the complex molecular mechanisms driving tumor progression contribute significantly to its poor prognosis. Dysregulated R-loops, three-stranded nucleic acid structures associated with genome instability, play a key role in the malignant characteristics of various tumors. However, the detailed role and mechanism of R-loops in HCC progression remain elusive and require further exploration. This study aimed to construct an R-loop scoring signature centered on prognosis and lipid metabolism, thereby enhancing our understanding of HCC progression and identifying potential therapeutic targets.MethodsIn this study, we utilized the single-cell RNA-sequencing (scRNA-seq) data from HCC patients (GSE149614 and CRA002308) to construct an R-loop scoring model based on the identified R-loop regulator genes (RLRGs) related to HBV infection through WGCNA analysis. We also explored the tumor microenvironment and intercellular communication related to R-loop score. Additionally, a prognostic risk model based on the fatty acid metabolism-associated RLRGs was constructed using data from the TCGA database, and its association with immune infiltration, mutations, and drug sensitivity was analyzed. In vitro and in vivo experiments were performed to investigate the role of RLRG CLTC in lipid metabolism and HCC progression.ResultsUsing scRNA-seq data from HCC, we established an R-loop scoring model based on identified RLRGs related to HBV infection. Moreover, the more suppressive tumor immune microenvironment and stronger intercellular communication were displayed in malignant cells with high R-loop scores. The cell trajectory and cellular metabolism analysis exhibited a significant association between lipid metabolism and RLRGs. Additionally, we constructed a prognostic risk model consisting of 8 RLRGs related to fatty acid metabolism, which effectively evaluated the prognostic value, status of tumor immune microenvironment, gene mutations, and chemotherapeutic drug sensitivity for HCC patients. Notably, validation experiments suggested that CLTC could regulate lipid metabolism through R-loop formation and facilitate tumor progression in HCC.ConclusionCollectively, our study proposes an R-loop scoring model associated with tumor immune microenvironment, lipid metabolism and prognostic value. CLTC, an R-loop regulator, emerges as a promising prognostic biomarker and therapeutic target, offering new insights into potential treatment strategies for HCC patients.