bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review and data synthesis on the treatment of sexual violence victimization by an intimate partner
Authors: Karakurt Gunnur , Baier Allison L. , Bowling Alexandra R. , Singuri Srinidhi , Oguztuzun Cerag , Bolen Shari 
Published: September 2023

AbstractThis study aims to conduct a systematic review and synthesis on the treatment of sexual violence victimization by an intimate partner evaluating specifically the impact of treatment on mental health outcomes of female sexual intimate partner violence (IPV) survivors. We followed the Cochrane Handbook for Systemic Reviews of Interventions guidelines for the process of conducting systematic reviews. We were unable to conduct meta‐analyses due to the substantial heterogeneity of the interventions for IPV. A qualitative summary of 6 controlled studies identified no benefit to the treatment of sexual coercion, posttraumatic stress disorder, depression, or anxiety for female sexual IPV survivors. However, we are limited by a paucity of data for each outcome on this subject. In conclusion, sexual coercion is a complex issue that has adverse effects on mental health and the well‐being of the survivors. More research is needed that investigates what kind of interventions are effective for this specific population.
Thirty years of BDNF study in central myelination: From biology to therapy
Authors: Xiao Junhua 
Published: September 2023

AbstractBeing the highest expressed neurotrophin in the mammalian brain, the brain‐derived neurotrophic factor (BDNF) is essential to neural development and plasticity in both health and diseases. Following the discovery of BDNF by Yves‐Alain Barde in 1982, the main feature of BDNF's activity in myelination was first described by Cellerino et al. in 1997. Since then, genetic manipulation of the BDNF‐encoding gene and its receptors in murine models has revealed the contribution of BDNF to the myelinating process in the central nervous system (CNS). The series of BDNF or receptor mouse mutants as well as the BDNF polymorphism in humans have provided new insights into the roles that BDNF signaling plays in myelination in a complex manner. 2024 marks the 30th year of BDNF's research in myelination. Here, we share our perspective on the 30‐year history of BDNF in the field of CNS myelination from phenotyping to therapeutic development, focusing on genetic evidence regarding the mechanism by which BDNF regulates myelin formation and repair in the CNS. This review also discusses the current hypotheses of BDNF's action on CNS myelination: axonal‐ and oligodendroglial‐driven mechanisms, which may be ultimately activity‐dependent. Last, this review raises the challenges and opportunities of developing BDNF‐based therapies for neurodegenerative diseases, opening unanswered questions for future investigation.image
No association between metformin initiation and incident dementia in older adults newly diagnosed with diabetes
Authors: Wu Che‐Yuan , Wang Christa , Saskin Refik , Shah Baiju R. , Kapral Moira K. , Lanctôt Krista L. , Herrmann Nathan , Cogo‐Moreira Hugo , MacIntosh Bradley J. , Edwards Jodi D. , Swardfager Walter 
Published: September 2023

AbstractBackgroundMetformin has been suggested to reduce dementia risk; however, most epidemiologic studies have been limited by immortal time bias or confounding due to disease severity.ObjectivesTo investigate the association of metformin initiation with incident dementia using strategies that mitigate these important sources of bias.MethodsResidents of Ontario, Canada ≥66 years newly diagnosed with diabetes from January 1, 2008 to December 31, 2017 entered this retrospective population‐based cohort. To consider the indication for metformin monotherapy initiation, people with hemoglobin A1c of 6.5%–8.0% and estimated glomerular filtration rate ≥45 mL/min/1.73 m2 were selected. Using the landmark method to address immortal time bias, exposure was grouped into “metformin monotherapy initiation within 180 days after new diabetes diagnosis” or “no glucose‐lowering medications within 180 days.” To address disease latency, 1‐year lag time was applied to the end of the 180‐day landmark period. Incident dementia was defined using a validated algorithm for Alzheimer's disease and related dementias. Adjusted hazard ratios (aHR) and confidence intervals (CIs) were estimated from propensity‐score weighted Cox proportional hazard models.ResultsOver mean follow‐up of 6.77 years from cohort entry, metformin initiation within 180 days after new diabetes diagnosis (N = 12,331; 978 events; 65,762 person‐years) showed no association with dementia risk (aHR [95% CI] = 1.05 [0.96–1.15]), compared to delayed or no glucose‐lowering medication initiation (N = 22,369; 1768 events; 117,415 person‐years).ConclusionEarly metformin initiation was not associated with incident dementia in older adults newly diagnosed with diabetes. The utility of metformin to prevent dementia was not supported.
Lifestyle Entrepreneurship: Literature Review and Future Research Agenda
Authors: Ivanycheva Diana , Schulze William S. , Lundmark Erik , Chirico Francesco 
Published: September 2023

AbstractResearch in leading entrepreneurship and management journals has tended to conceptualize entrepreneurship as motivated by the goals of wealth, income, or social value creation. This research has thus largely overlooked entrepreneurial motivations such as the desire to engage in particular activities that the entrepreneurs find rewarding or the desire to live in particular locations. The literature on such Lifestyle Entrepreneurship (LE) includes research on artisan, artistic, craft, creative, fitness, hobbyist, leisure, sport, and tourism entrepreneurship. This literature has grown quickly over the last decade, but it is scattered across a range of domains, disciplines, and journals and lacks conceptual clarity. In this review, we take stock, synthesize and offer definitions and a framework for investigation of LE that allows for its development and theoretical integration with, and contribution to, existing entrepreneurship theory. We conceptualize LE in relation to its purpose and function, identify different types of LE, and examine their respective antecedents, behaviours, and outcomes. We propose a research agenda based on the merits of viewing LE as a distinctive and theoretically important domain for the study of entrepreneurship and highlight the vital role that LE plays in enriching both individual and social welfare.
Pre‐illness dietary risk factors in dogs with chronic enteropathy
Authors: Trewin Isla , Kathrani Aarti 
Published: September 2023

AbstractBackgroundDietary factors have been extensively studied as potential triggers of inflammatory bowel disease in humans. Scant literature exists regarding diet as a pre‐illness risk factor in dogs with chronic enteropathy (CE).HypothesisTo evaluate possible pre‐illness dietary risk factors in dogs with CE.AnimalsNinety‐five client‐owned dogs; 48 with CE (25 presumptive and 23 confirmed) and 47 without a history of signs of gastrointestinal disease.MethodsRetrospective case‐control questionnaire‐based study at a veterinary referral teaching hospital in the United Kingdom. Diet history was obtained relating to the onset of initial presenting signs for all dogs. The main diet consumed underwent ingredient analysis and caloric distribution calculation using a guaranteed analysis convertor software. Length of time the main diet was fed and adherence to the World Small Animal Veterinary Association Global Nutrition Committee guidelines was also recorded.ResultsThe frequency of the main diet containing no carbohydrate was greater for controls (5/47 dogs, 11%) vs the combined presumptive and confirmed CE dogs (0/48 dogs, 0%; P = .05). Fewer dogs with confirmed CE were fed a main diet containing red meat as the primary protein source (2/23 dogs, 9%) vs controls (15/47 dogs, 32%; P = .03). A main diet moisture percentage of ≤14% as fed was significantly associated with confirmed CE in logistic regression analysis (OR 5.71 [95% CI: 1.18‐27.69]; P = .03).Conclusions and Clinical ImportanceThe presence of dietary carbohydrate, protein source, and dietary moisture content, or factors related to moisture content such as preservatives, might play a role as potential pre‐illness dietary risk factors in dogs with CE.
Prevalence of cutaneous and mucosal lesions in dairy cattle admitted to a Canadian Veterinary Teaching Hospital from 2018 to 2019
Authors: Guarnieri Eloi , Sauvé Frédéric , Arsenault Julie , Francoz David 
Published: September 2023

AbstractBackgroundThe prevalence, anatomical distribution, or nature of cutaneous, hair and oral mucosal abnormalities (CHMAs) in cattle is uncertain.ObjectivesTo determine how often dairy cattle admitted to a veterinary teaching hospital (VTH) had CHMAs (except for foot and ear canal) on physical examination and if there was an age‐related difference.AnimalsFour hundred and thirty‐three cattle: cattle <3 months (n = 85), cattle 3 to 24 months (n = 73), and cattle >24 months (n = 275).MethodsIn this descriptive, observational, prospective study, CHMAs of dairy cattle admitted to the VTH of the Université de Montréal were recorded over 1 year. Prevalences were calculated. Dermatological examinations were performed within 48 hours of admission, according to a glossary. Chi‐square tests were used to compare prevalence between age groups.ResultsThe 433 cattle were mostly females (97.5%) and of the Holstein breed (89.8%). The prevalence of cattle <3 months presenting with at least 1 identifiable CHMA was 65% (55/85). In cattle 3 to 24 months old, it was 90% (66/73), and in cattle >24 months, it was 99.3% (273/275). There were significant differences (P < .001) between the prevalence of CHMAs localized on the ischia, ilia, stifles, hocks, carpi, flank, lateral neck, dorsal cervical, and cornual regions in cattle >24 months vs <3 months.Conclusions and Clinical Importance.CHMAs were highly prevalent and age‐specific. Calluses on the carpi and hocks of cattle >24 months were the most common CHMAs.
Assessment of out‐of‐plane structural defects using parallel laser line scanning system
Authors: Li Chaobin , Su Ray Kai Leung , Pan Xiao 
Published: September 2023

AbstractA precise parallel laser line scanning system has been developed to assess the depth of out‐of‐plane structural defects on concrete surfaces. This system comprises a digital camera, dual line laser diodes, and positioning rigid arms that create a triangulation‐based setup. Laser lines are distorted when projected onto an out‐of‐plane defect. A new image processing algorithm has been devised to extract depth information from the distorted laser strips. Parallel laser lines are used to ensure that imaged laser strips do not intersect, thereby simplifying the depth assessment of defects at different distances and enabling the generation of defect profiles from a single image. The system has been validated through laboratory and field tests, demonstrating its effectiveness and accuracy. Compared to other noncontact measurement techniques, this system stands out due to its simplicity, cost‐effectiveness, efficiency, and superior accuracy for long‐range measurements, rendering it suitable for on‐site scanning of textureless uneven engineering objects.
Higher‐order evidence and the duty to double‐check
Authors: Palmira Michele 
Published: September 2023

AbstractThe paper proposes an account of the rational response to higher‐order evidence whose key claim is that whenever we acquire such evidence we ought to engage in the inquiring activity of double‐checking. Combined with a principle that establishes a connection between rational inquiry and rational belief retention, the account offers a novel explanation of the alleged impermissibility of retaining one's belief in the face of higher‐order evidence. It is argued that this explanation is superior to the main competitor view which appeals to the notion of defeat.
Machine learning applications to personnel selection: Current illustrations, lessons learned, and future research
Authors: Campion Michael A. , Campion Emily D. 
Published: September 2023

AbstractMachine learning (ML) may be the biggest innovative force in personnel selection since the invention of employment tests. As such, the purpose of this special issue was to draw out research from applied settings to supplement the work that appeared in academic journals. In this overview article, we aim to complement the special issue in five ways: (1) provide a brief tutorial on some ML concepts and illustrate the potential applications in selection, along with their strengths and weaknesses; (2) summarize findings of the four articles in the special issue and provide an independent appraisal of the strength of the evidence; (3) identify some of the less‐obvious lessons learned and other insights that researchers new to ML might not clearly recognize from reading the special issue; (4) present best practices at this stage of the knowledge in selection; and (5) propose recommendations for future needed research based on the articles in the special issue and the current state of the science.
Parent and healthcare provider views of live varicella vaccination of pediatric solid organ transplant recipients
Authors: Condran Brian , Kervin Melissa , Burton Catherine , Blydt‐Hansen Tom D , Morris Shaun K. , Sadarangani Manish , Otley Anthony , Yong Elaine , Mitchell Hana , Bettinger Julie A. , Top Karina A. ,   the Special Immunization Clinic Network Investigators
Published: September 2023

AbstractBackgroundLive attenuated varicella vaccine (LAVV) has historically been contraindicated in children who are immunocompromised due to solid organ transplant (SOT) because of safety concerns. Recently, clinical guidelines were developed that support post‐transplant varicella vaccination in selected SOT recipients based on emerging evidence of LAVV safety. This qualitative study sought to explore barriers and facilitators to implementing the new guidelines, as well as acceptability of LAVV among healthcare providers (HCPs) and parents.MethodsHCPs and parents of transplant recipients were recruited from four sites using purposive sampling. Data from semi‐structured interviews were analyzed using an Interpretive Description approach that incorporated data from the interviews, academic knowledge and clinical experience, and drew from Grounded Theory and Thematic Analysis. The theoretical framework used was Adaptive Leadership.ResultsThirty‐four participants (16 HCPs and 18 parents) were included in the analysis. Parents developed skills in adaptive leadership that included strategies to protect their child against infectious diseases. Foundational information that live vaccines were absolutely contraindicated post‐transplant “stuck” with parents and led them to develop strategies other than vaccination to keep their child safe. Some parents struggled to understand that information previously presented as a certainty (contraindication of LAVV) could change. Their approach to adaptive leadership informed their appraisal of the new vaccination guidelines and willingness to accept vaccination.ConclusionsHCPs should adopt a family‐centered approach to communicating changing guidelines that considers parents' approach to adaptive leadership and discusses the changing nature of medical evidence. Trust between HCPs and parents can facilitate these conversations.
Transcriptomics integrated with metabolomics to characterize key pigment compounds and genes related to anthocyanin biosynthesis in Zanthoxylum bungeanum peel
Authors: Han Nuan , Sun Leiwen , Zhang Jie , Yuan Wei , Wang Cheng , Zhao Aiguo , Wang Dongmei 
Published: September 2023

AbstractZanthoxylum bungeanum is an important condiment with high economic value and its peel color is one of the main quality indexes. However, the key pigment compounds and related genes are still unclear affecting the quality control of the plants. In this study, the contents of four types of pigments were measured in Z. bungeanum and flavonoids were identified as the most important pigments. Based on the targeted flavonoid metabolomics of Z. bungeanum peels, 14 key pigment compounds were screened out from 152 flavonoids, among which cyanidin‐3‐O‐rutinoside and cyanidin‐3‐O‐glucoside were the most critical compounds for peel color. They were further verified to be present in nine varieties of Z. bungeanum by HPLC fingerprints. The 14 compounds were all associated with flavonoid and anthocyanin biosynthesis pathways and the 39 differentially expressed genes related to these pathways were annotated and screened based on transcriptomics. The genes ZbDFR, ZbANS, and ZbUFGT were identified as three key genes for anthocyanin synthesis in Z. bungeanum peels. Further qRT‐PCR results confirmed the reliability of transcriptomics and the accuracy of gene screening. Subsequent protein induced expression demonstrated that ZbANS and ZbUFGT were expressed after 12 h induced by IPTG while ZbDFR was expressed after 15 h. Further transient and stable transformation analysis confirmed that both anthocyanin content and the expression of ZbDFR were significantly increased in overexpression Z. bungeanum leaves and Nicotiana benthamiana. The functional effect of stable transformation of ZbDFR was more significant than that of transient transformation with a 7.67‐fold/1.49‐fold difference in total anthocyanin content and a 42.37‐fold/12.32‐fold difference in the expression of ZbDFR. This study provides new insights into the chemical composition and the molecular mechanisms of Z. bungeanum peel color and lays an effective foundation for the color quality control, multi‐purpose utilization of Z. bungeanum and the creation of new germplasm.
B2O3 nanoparticles alleviate salt stress in maize leaf growth zones by enhancing photosynthesis and maintaining mineral and redox status
Authors: El‐Shafey Nadia Mohamed , Avramova Viktoriya , Beemster Gerrit T. S. , Korany Shereen Magdy , AbdElgawad Hamada 
Published: September 2023

AbstractSalt stress induces significant loss in crop yield worldwide. Although the growth‐stimulating effects of micronutrient nanoparticles (NPs) application under salinity have been studied, the molecular and biochemical mechanisms underlying these effects are poorly understood. The large size of maize leaf growth zones provides an ideal model system to sample and investigate the molecular and physiological bases of growth at subzonal resolution. Using kinematic analysis, our study indicated that salinity at 150 mM inhibited maize leaf growth by decreasing cell division and expansion in the meristem and elongation zones. Consistently, salinity downregulated cell cycle gene expression (wee1, mcm4, and cyclin‐B2‐4). B2O3 NP (BNP) mitigated the stress‐induced growth inhibition by reducing the decrease in cell division and expansion. BNP also enhanced the photosynthesis‐related parameters. Simultaneously, chlorophyll, phosphoenolpyruvate carboxylase and ribulose‐1,5‐bisphosphate carboxylase/oxygenase were stimulated in the mature zone. Concomitant with growth stimulation by BNP, mineral homeostasis, particularly for B and Ca, was monitored. BNP reduced oxidative stress (e.g., lessened H2O2 generation along the leaf zones and reduced lipid peroxidation in the mature zone) induced by salinity. This resulted from better maintenance of the redox status, that is, increased the glutathione‐ascorbate cycle in the meristem and elongation zones, and flavonoids and tocopherol levels in the mature zone. Our study has important implications for assessing the salinity stress impact mitigated by BNP on maize growth, providing a basis to improve the resilience of crop species under salinity stress conditions.
Evaluation of sexed semen‐based artificial insemination in Tharparkar cattle under organized farm condition
Authors: Patra Manas Kumar , Sasidharan Jisna Kuttiyeri , Rajput Atul Singh , Sharma Renu , Reza Md Rehan Ahmad , Das Goutam Kumar , Tomar Atul Kumar Singh , Ghosh Subrata Kumar , Gaur Gyanendra Kumar 
Published: September 2023

AbstractSexed semen facilitates additional female calf production for the expansion of a herd at a faster rate and also curtails the surplus production of unwanted male calves. A study was conducted to evaluate the performance of sexed semen in indigenous Tharparkar cows based on 114 artificial inseminations (AI) performed at natural oestrus using two protocols i.e., single AI (n = 48) and double AI (n = 66). Overall, the first service conception rate (CR) was significantly higher in double (53.0%) than single (33.3%) AI protocol. The odds ratio of conception rate in double AI was 2.26 (χ2 = 4.4, df = 1, p = .04) with respect to single AI. The time that elapsed since the detection of oestrus to insemination was also analysed. In a single AI protocol, the CR was higher (p < .05) at 16 h (54.6%) than insemination at 8 h (27.0%) following the onset of oestrus. Yet, the CR using double AI protocol did not differ (p = .73) significantly when AIs were performed either at 8 h and 24 h (51.9%) or 16 h and 24 h (57.1%) post onset of oestrus. Besides, like the single AI protocol, the parity of the animals also influenced the CR, being higher in heifers (n = 22) than those of parous (n = 92) cows (72.73 vs. 40.43%, χ2 = 7.48, df = 1, p = .006) in the present study. The odds ratio of conception in heifers was 3.93 with respect to parous cows. Overall, the birth of female calf was 91.7%. In conclusion, the present study indicates a future promise of the sexed semen for the production of more female offspring from Tharparkar cattle.
Early warning systems and end‐user decision‐making: A risk formalism tool to aid communication and understanding
Authors: de Elía Ramón , Ruiz Juan José , Francce Verónica , Lohigorry Pedro , Saucedo Marcos , Menalled Matías , D'Amen Daniela 
Published: September 2023

AbstractIn this work, we introduce a formalism to highlight the role of decision‐making implicit in the setup of early warning systems (EWSs) and its consequences with respect to loss avoidance for end users. The formalism, a close relative of the cost/loss approach, combines EWS verification scores with traditional expressions of risk from the point of view of the user. This formalism articulates in mathematical format many well‐known issues surrounding EWS usage, offering a conceptual anchor for concepts that otherwise may seem to wobble among the multidisciplinary perspectives participating in the EWS chain.This decision model is visually represented in a variation of the popular “performance diagram” used in forecast and warning verification. Our diagram adds to this the perspective of a generic user, in an effort to gain insight into how choices made regarding EWS settings may determine which users benefit from warnings and which do not. Although these results are based on a conceptual model, they are useful to better understand the actual benefits experienced by users and to highlight aspects that may temper unrealistic expectations on EWSs.The recent United Nations initiative to extend EWSs for natural hazards to all nations within 5 years will make EWSs more common and more public. The approach proposed here can be a tool to promote greater transparency and improve the necessary dialog between warning issuers and users in order to reduce loss.