bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart5Grid Solutions for enhanced TSO grid observability and manageability in massive RES penetration environment
Authors: Shangov Daniel , Vlachkov Krassimir , Rumenova Ralitsa , Hristov Georgi , Velkov Atanas , Antonopoulos Angelos , Cadenelli Nicola , Tzanis Nikolaos , Brodimas Dimitrios , Rantopoulos Michalis , Chochliouros Ioannis , Vlahodimitropoulou Vasiliki 
Published: July 2023

This article presents the latency minimisation potential provided by the Smart5Grid Open Experimentation Platform (OEP) developed by the Horizon 2020 Smart5Grid Research and Innovation (R&I) project. It discusses the OEP performance and provides experimental data to substantiate its contribution to improving observability and manageability of distributed renewable generation in power grids. That experimental proof is delivered by two pilots running on the OEP: Demo 1 Millisecond Level Precise Distribution Generation Control, and Demo 2 Real-time Wide Area Monitoring (WAM) pilot of 5G virtual Phasor Data Concentrator v(PDC) capabilities for WAM of end-to-end electricity grids. This work reports two Network Applications (NetApps) created to support both demos and provides experimental evidence that the OEP offers latency of comparable measure to well-established wire-bound communications in addition to availability and reliability on top of by-design flexibility, scalability and modularity, which are especially relevant to power systems with high shares of Distributed Renewable Energy Recourses (DRERs). The software and methods used for the OEP development and experimental testbeds applied to measure its latency performance in both tailored pilot demos are explained at length. The test results are presented and interpreted with a view to discussing potential contributions of the presented 5G-enabled solutions for power grid smartification in conditions of high rollout of distributed renewable generation. All pilot demos generate openly accessible data, except where specific security restrictions are applicable.
Staging enmity: reading populist productions of shame with Jelinek’s On the Royal Road
Authors: Prade-Weiss Juliane 
Published: July 2023

Background: Populism is often perceived as a shamelessly loud segment of political discourse. However, Jelinek’s play On the Royal Road, written on the occasion of Trump’s 2016 election as US president, suggests that populism leads to societal silencing. Jelinek’s text expounds that when a society’s public sphere is marked by ubiquitous enmity against an imagined “we”, grounded in antagonism, then the possibility of speaking to one another disappears, because speaking to one another is based on the willingness to give one’s counterpart space and listen to them. In a public discourse that stages enmity, the counterpart vanishes. Therefore, populism, loud as it is, leads to the silencing of whole communities insofar as they are left with nothing in common but enmity. Method: Critical discourse analysis is used to contextualise close readings of select passages of Jelinek’s play with recent social sciences and humanities research on global populisms to highlight what literary language and the dramatic form can contribute to understanding populism. Results: The silencing populisms entail is fed, in large part, by a dynamics linking the interpersonal emotion of shame to its discursive exploitation in shamelessness and shaming: populist voices transgress rules of democratic debate in the public sphere to elicit outrage by mainstream politics, media, and civil society, which often retort populist shamelessness by shaming populist actors. The audience excitement populist leaders and supporters generate is an important factor in normalizing the emotional, moralizing populist polarization of “us” versus “them” that undermines differentiated discussion and a dispute of arguments. Conclusion: While media and research commonly suggest that with the populist reduction of politics to a spectacle, citizens become a passive audience, the article expounds that audiences play a key role in the production of populist enmity. This insight offers an alley to counteract populism.
Checkpoint kinase interaction with DNA polymerase alpha regulates replication progression during stress
Authors: Hadjicharalambous Andreas , Whale Alex J. , Can Geylani , Skehel J. Mark , Houseley Jonathan M. , Zegerman Philip 
Published: July 2023

Background: In eukaryotes, replication stress activates a checkpoint response, which facilitates genome duplication by stabilising the replisome. How the checkpoint kinases regulate the replisome remains poorly understood. The aim of this study is to identify new targets of checkpoint kinases within the replisome during replication stress. Methods: Here we use an unbiased biotin proximity-ligation approach in Saccharomyces cerevisiae to identify new interactors and substrates of the checkpoint kinase Rad53 in vivo. Results: From this screen, we identified the replication initiation factor Sld7 as a Rad53 substrate, and Pol1, the catalytic subunit of polymerase a, as a Rad53-interactor. We showed that CDK phosphorylation of Pol1 mediates its interaction with Rad53. Combined with other interactions between Rad53 and the replisome, this Rad53-Pol1 interaction is important for viability and replisome progression during replication stress. Conclusions: Together, we explain how the interactions of Rad53 with the replisome are controlled by both replication stress and the cell cycle, and why these interactions might be important for coordinating the stabilisation of both the leading and lagging strand machineries.
Decision-Making Delegation in Banks
Authors: Dlugosz Jennifer , Gam Yong Kyu , Gopalan Radhakrishnan , Skrastins Janis 
Published: July 2023

Using natural disasters as shocks to local economies, we document that a bank branch’s ability to set deposit rates locally has real effects. Following disasters, branches with rates set locally increase deposit rates more and experience higher deposit volumes in affected counties. Consistent with imperfect insurance from internal capital markets, banks with more branches setting rates locally relatively expand mortgage lending in affected counties. House prices recover faster in local areas where more branches’ rates are set locally. This paper was accepted by Tomasz Piskorski, finance. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4856 .
CIRCULAR EXTERNAL FIXATOR REMOVAL IN THE OUTPATIENT CLINIC USING REGIONAL ANAESTHESIA: A PILOT STUDY OF A NOVEL APPROACH
Authors: Williams Luke , Stamps Giles , Peak Helen , Singh Shiv , Narayan Badri , Graham Simon , Peterson Nicholas 
Published: July 2023

IntroductionExternal fixation (EF) devices are commonly used in the management of complex skeletal trauma, as well as in elective limb reconstruction surgery for the management of congenital and acquired pathology. The subsequent removal of an EF is commonly performed under a general anaesthetic in an operating theatre. This practice is resource intensive and limits the amount of operating theatre time available for other surgical cases. We aimed to assess the use of regional anaesthesia as an alternative method of analgesia to facilitate EF removal in an outpatient setting.Materials & MethodsThis prospective case series evaluated the first 20 consecutive cases of EF removal in the outpatient clinic between 10/06/22 to 16/09/22. Regional anaesthesia using ultrasound-guided blockade of peripheral nerves was administered using 1% lidocaine due to its rapid onset and short half-life. Patients were assessed for additional analgesia requirement, asked to evaluate their experience and perceived pain using the Visual Analogue Scale (VAS).ResultsTwenty patients were included in the study. The mean age was 46.6 years (range 21–85 years). Two thirds were male patients (N=13). Post procedure all patients indicated positive satisfaction ratings, each participant responding as either ‘satisfied’ (N=4), ‘very satisfied’ (N=15) or ‘highly satisfied’ (N=1). In addition, 85% of participants reported they would opt for this method of EF removal in future should it be necessary. VAS for pain immediately following completion of the procedure was low, with an average score of 0.45 (range 0–4), where a score of 0= ‘No pain’, and 10 = ‘worst pain possible’.ConclusionsWe present the first description of outpatient EF removal using sole regional anaesthesia, with a prospective case series of 20 EF removed in fully awake patients. This novel technique is cost-effective, reproducible, and safe. This not only reduces the burden of these surgical cases on an operating list but also improves patient experience when compared to other forms of conscious sedation. By eliminating the use of Entonox and methoxyflurane for sedation and analgesia, this project demonstrates a method of improving environmental sustainability of surgery, anaesthesia and operating theatres.
RESULTS OF EXOGEN THERAPY FOR THE TREATMENT OF FRACTURE NONUNION OR DELAYED HEALING
Authors: Doherty Ciaran , McKee Christopher Madden- , Foster Andrew 
Published: July 2023

IntroductionNon-union is an unfortunate outcome of the fracture healing process for some patients; with an estimated annual incidence of 17.4- 18.9 per 100,00. The management of these patients depicts a significant clinical challenge for surgeons and financial burden to health services. External ultrasound stimulation devices (ExogenTM) have been highlighted as a novel non invasive therapy to achieve union in cases of delayed and non-union. The aim of the current study was to assess the rate of union in patients using ExogenTM therapy for delayed fracture union in a district general hospital.Materials & MethodsThis is a single centre retrospective continuous cohort study. Patients were identified from a prospective database of all patients prescribed ExogenTM therapy between June 2013- September 2021 in a district general hospital. Patient data was collected retrospectively using electronic patient records. Fracture union was assessed both clinically and radiographically and recorded in patient records. Failure of treatment was defined as progression to operative treatment due to lack of progression with ultrasound therapy or established asymptomatic non-union. Patient were excluded from the study if ExogenTM therapy was prescribed within 6 weeks of injury.Results142 potential patient were identified from the database. 35 patients were excluded from the data set (17 patients due to insufficient data available, 9 lost to follow up, 4 died and 5 excluded due to early application of ExogenTM therapy). 58 Patients progressed to union with an average time to union of 41 weeks. 49 cases failed to progress to union, of which 7 cases had conversion to operative management prior to completion of single course of ExogenTM therapy and were excluded from all other data review. 12% of cases that failed to unite with ultrasound therapy required multiple operations to establish union.ConclusionsA union rate of 58% was reported by the current study, which is lower than previously published. This likely reflects the heterogenous nature of the patient population and fracture distribution included. However, this is potentially a more reflective union rate for the general population than previously published. There were no adverse events associated with the use of ExogenTM therapy in the current study. Therefore supporting its use as a first line management to promote union in delayed fracture union in the general population. Additionally, failure to achieve fracture union with utilisation of ExogenTM therapy was associated with risk for requirement of multiple surgeries to achieve union. This could serve as an indicator for surgeon to consider the requirement additional measures at the initial surgical procedure.
LIMBDREAM: THE LIMB RECONSTRUCTION REGISTRY OF EXPERIENCE, ASPIRATION, AND MEASURES
Authors: Morrison Stewart , Formosa Melissa , Donnan Leo 
Published: July 2023

IntroductionPatient-reported outcome measures (PROMs) has gained momentum in the orthopaedic literature. The GOAL-LD (Gait Outcomes Assessment List for Limb Deformity) incorporates the framework of The WHO International Classification of Functioning, Disability and Health and correlates highly with the Paediatric Outcomes Data Collection Instrument (PODCI) when applied in a limb reconstruction setting. The Royal Children's Hospital Melbourne, Australia, supported by The University of Melbourne is designing and implementing a Limb Reconstruction Registry, prospectively enrolling patients with a number of key conditions and provide a mechanism for capturing surgical data and PROMs at regular follow-up intervals. LimbDREAM (The Limb Reconstruction Registry of Experience, Aspiration and Measures) has begun recruiting participants, and this paper serves as a narrative review of our design and implementation process.Materials & MethodsAfter provision of a research grant, audit was conducted to examine local case mix and estimate recruitment based on conditions selected. Literature review was focussed on (i) registries in the paediatric limb reconstruction domain and (ii) use of PROMs across conditions selected. A high-level process-flow chart was constructed in order to inform governance and staffing requirements in addition to REDCap Database structure. Local as well as scalable deployment was considered. Alpha and beta testing was performed by principal and associate investigators prior to participant recruitment.ResultsAudit identified 6 condition streams for inclusion: Congenital limb deficiencies, congenital pseudarthrosis of the tibia, bone dysplasias, bone tumours, amputation, and complex deformity of other etiology. Literature review identified 20 PROMs used across these conditions, with limited validation studies and significant implementation heterogeneity. REDCap database design took longer than anticipated (planned 10 months, actual 18 months) before being recruitment ready, due to the complexity of ensuring data collection logic would work across highly diverse patient journeys. Initial recruitment across all streams has been promising. Email and text message reminders have proved helpful in increasing survey return rates.ConclusionsProspective collection of PROMs as well as surgical data via a standardized dataset will provide the basis for future condition-specific research, with the ability to support nested trials. Implementation requires forethought with regard to time frames and staffing for non-automated steps as well as data integrity review. The next phase of the LimbDREAM project will be to integrate use of the Registry into our weekly Limb Reconstruction Meeting to ensure that operative plans and data are captured close to the point of care.
A CASE REPORT OF A RARE POST-TRAUMATIC INFECTED REGENERATE CORTICOTOMY FOR LENGTHENING FOLLOWING A FRAME ANKLE FUSION
Authors: Haq Labeeba , Thomson Lauren , Wright Sally , Bose Deepa 
Published: July 2023

IntroductionWe present a case of a 49-year-old patient who initially presented in May 2020 with an open pilon fracture. Managed with initial debridement, fixation and flap - who subsequently underwent circular frame application for failure of fixation, requiring a transport to fusion frame who developed beta-haemolytic streptococcus A within the site of the proximal corticotomy.Materials & MethodsA systematic review of the literature was conducted searching EMBASE, MEDLINE and Cochrane library for all articles discussing infected bone regenerate- a paucity of information was found. Abstracts were independently reviewed by 2 authors (LH and LT). In total, there were 16 papers, and then subsequently analysed we identified two case reports regarding infected regenerate.ResultsDeveloping an infection in a regenerate is highly rare with very few reported cases within the published literature. The literature identified risk factors for an infected regenerate, with open fracture and smoking being the two consistent factors. The open fracture deep infection rate is cited at 10% in most publications, this is at the site of the open fracture and not within the regenerate.ConclusionsInfection within the regenerate during distraction osteogenesis is highly unusual, with only two other published papers in the literature to the best of our knowledge. This should be borne in mind when managing patients with infection of unknown sources in cases of distraction osteogenesis.
THE ENVIRONMENTAL IMPACT AND SUSTAINABILITY OF TOTAL HIP AND KNEE ARTHROPLASTY
Authors: Prakash Rohan , Abid Husnain , Wasim Abdus , Sharma Akash , Agrawal Yuvraj 
Published: July 2023

The National Health Service produces over 500,000 tonnes of waste and 25 mega tonnes of CO2 annually. Operating room waste is segregated into different streams which are recycled, disposed of in landfill sites, or undergo costly and energy-intensive incineration processes.By assessing the quantity and recyclability of waste from primary hip and knee arthroplasty cases, we aim to identify strategies to reduce the carbon footprint of arthroplasty surgery.Data was collected prospectively at a tertiary orthopaedic hospital, in the theatres of six arthroplasty surgeons between April – July 2022. Fifteen primary total hip arthroplasty (THA) and 16 primary total knee arthroplasty (TKA) cases were included; revision and complex primary cases were excluded.Waste was categorised into non-hazardous waste, hazardous waste, recycling, sharps, and linens. Each waste category was weighed. Items disposed as non-hazardous waste were catalogued for a sample of 10 TKA and 10 THA cases. Recyclability of items was determined from packaging.Average total waste generated for THA and TKA were 14.46kg and 17.16kg respectively, with TKA generating significantly greater waste (p < 0.05).On average only 5.4% of waste was recycled in TKA and just 2.9% in THA cases. The mean recycled waste was significantly greater in TKA cases compared to THA, 0.93kg and 0.42kg respectively (p < 0.05).Hazardous waste represented the largest proportion of the waste streams for both TKA (69.2%) and THA (73.4%). On average TKA generated a significantly greater amount (11.87kg) compared to THA (10.61kg), p < 0.05.Non-hazardous waste made up 15.1% and 11.3% of total waste for TKA and THA respectively.In the non-hazardous waste, only two items (scrub brush packaging and sterile towel packaging) were identified as recyclable based on packaging.We estimate that annually total hip and knee arthroplasty generates over 2.7 million kg of waste in the UK. Through increased use of recyclable plastics for packaging, combined with clear labelling of items as recyclable, medical suppliers can significantly reduce the carbon footprint of arthroplasty. Our data highlight only a very small percentage of waste is recycled in total hip and knee arthroplasty cases.
ISCHIAL SCREW FIXATION CAN PREVENT CUP MIGRATION IN 3D-PRINTED CUSTOM ACETABULAR COMPONENTS FOR COMPLEX HIP RECONSTRUCTION
Authors: Madanipour Suroosh , Lemanu Daniel , Jayadev Chethan , Aston Will , Donaldson James , Miles Jonathan , Carrington Richard , McCulloch Robert , Skinner John 
Published: July 2023

Custom acetabular components have become an established method of treating massive acetabular bone defects in hip arthroplasty. Complication rates, however, remain high and migration of the cup is still reported. Ischial screw fixation (IF) has been demonstrated to improve mechanical stability for non-custom, revision arthroplasty cup fixation. We hypothesise that ischial fixation through the flange of a custom acetabular component aids in anti-rotational stability and prevention of cup migration.Electronic patient records were used to identify a consecutive series of 49 custom implants in 46 patients from 2016 to 2022 in a unit specializing in complex joint reconstruction. IF was defined as a minimum of one screw inserted into the ischium passing through a hole in a flange on the custom cup.The mean follow-up time was 30 months. IF was used in 36 cups. There was no IF in 13 cups. No difference was found between groups in age (68.9 vs. 66.3, P = 0.48), BMI (32.3 vs. 28.2, P = 0.11) or number of consecutively implanted cups (3.2 vs. 3.6, P = 0.43). Aseptic loosening with massive bone loss was the primary indication for revision. There existed no difference in Paprosky grade between the groups (P = 0.1). 14.2% of hips underwent revision and 22.4% had at least one dislocation event.No ischial fixation was associated with a higher risk of cup migration (6/13 vs. 2/36, X2 = 11.5, P = 0.0007). Cup migration was associated with an increased risk for all cause revision (4/8 vs. 3/38, X2 = 9.96, P = 0.0016, but not with dislocation (3/8 vs. 8/41, X2 = 1.2, P = 0.26).The results suggest that failure to achieve adequate ischial fixation, with screws passing through the flange of the custom component into the ischium, increases the risk of cup migration, which, in turn, is a risk factor for revision.
IS VIRTUAL REALITY THE ANSWER? A STUDY TO VALIDATE THE USE OF HIGH-FIDELITY VIRTUAL REALITY SIMULATION IN HIP ARTHROSCOPY TRAINING
Authors: Schapira Benjamin , Spanoudakis Emmanuel , Jaiswal Parag , Patel Akash 
Published: July 2023

Surgical trainees are finding it increasingly more challenging to meet operative requirements and coupled with the effects of COVID-19, we face a future of insufficiently trained surgeons. As a result, virtual reality (VR) simulator training has become more prevalent and whilst more readily accepted in certain arthroscopic fields, its use in hip arthroscopy (HA) remains novel. This project aimed to validate VR high-fidelity HA simulation and assess its functional use in arthroscopic training.Seventy-two participants were recruited to perform two basic arthroscopic tasks on a VR HA simulator, testing hip anatomy, scope manipulation and triangulation skills. They were stratified into novice (39) and experienced (33) groups based on previous arthroscopy experience. Metric parameters recorded from the simulator were used to assess construct validity. Face validity was evaluated using a Likert-style questionnaire. All recordings were reviewed by 2 HA experts for blinded ASSET score assessment.Experienced participants were significantly faster in completing both tasks compared with novice participants (p<0.001). Experienced participants damaged the acetabular and femoral cartilage significantly less than novice participants (p=0.011) and were found to have significantly reduced path length of both camera and instrument across both tasks (p=0.001, p=0.007), demonstrating significantly greater movement economy. Total ASSET scores were significantly greater in experienced participants compared to novice participants (p=0.041) with excellent correlation between task time, cartilage damage, camera and instrument path length and corresponding ASSET score constituents. 62.5% of experienced participants reported a high degree of realism in all facets of external, technical and haptic experience with 94.4% advising further practice would improve their arthroscopic skills. There was a relative improvement of 43% in skill amongst all participants between task 1 and 2 (p<0.001).This is the largest study to date validating the use of simulation in HA training. These results confirm significant construct and face validity, excellent agreement between objective measures and ASSET scores, significant improvement in skill with continued use and recommend VR simulation to be a valuable asset in HA training for all grades.