bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrieval of surface waves from high-speed-train-induced vibrations using seismic interferometry
Authors: Mi Binbin , Xia Jianghai , Xu Yixian , You Baiyang , Chen Yunfeng 
Published: May 2023

Train traffic has recently been realized as a potential seismic source for imaging and monitoring shallow subsurface structures. High-speed trains usually move on viaducts and generate seismic wavefields through bridge piers. This kind of source is not randomly distributed in space and time and thus indicates the characteristic of self-correlation. We find that correlated sources of one high-speed train running over piers make time-delayed spurious signals in the crosscorrelation functions. The direct-wave interferometry with correlated sources is proposed and demonstrates that stacking the interferometric responses from high-speed trains with different speeds may reduce the spurious imprint of source self-correlations, but it cannot remediate the problem. The influence of the source wavelet can be eliminated by using cross coherence. Stationary-phase segment selection and stacking can reduce the bias generated by trains moving out of the stationary-phase zone of station pairs. The validity is demonstrated by using synthetic data with inline and out-of-line linear arrays. We apply the proposed scheme to field data with nine high-speed train events. Multimodal Rayleigh waves were retrieved and shallow shear-wave velocities were inverted from multimodal dispersion data in a range of 4–25 Hz. The results bring a novel approach for the imaging and monitoring of the shallow subsurface using high-speed-train-induced vibrations.
A platform for modular assembly and feeding of micro-organoids on standard Petri dishes
Authors: Nebuloni Federico , Morgan Joseph , Walsh Edmond J. , Cook Peter R. 
Published: May 2023

ABSTRACT
Organoids grow in vitro to reproduce structures and functions of corresponding organs in vivo. As diffusion delivers nutrients over only ∼200 µm, refreshing flows through organoids are required to avoid necrosis at their cores; achieving this is a central challenge in the field. Our general aim is to develop a platform for culturing micro-organoids fed by appropriate flows that is accessible to bioscientists. As organs develop from layers of several cell types, our strategy is to seed different cells in thin modules (i.e. extra-cellular matrices in stronger scaffolds) in standard Petri dishes, stack modules in the required order, and overlay an immiscible fluorocarbon (FC40) to prevent evaporation. As FC40 is denser than medium, one might expect medium to float on FC40, but interfacial forces can be stronger than buoyancy ones; then, stacks remain attached to the bottom of dishes. After manually pipetting medium into the base of stacks, refreshing upward flows occur automatically (without the need for external pumps), driven mainly by differences in hydrostatic pressure. Proof-of-concept experiments show that such flows support clonal growth of human embryonic kidney cells at expected rates, even though cells may lie hundreds of microns away from surrounding fluid walls of the two immiscible liquids.
The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice
Authors: Wang Yan , Lopez-Bellido Roger , Huo Xiaojiao , Kavelaars Annemieke , Galko Michael J. 
Published: May 2023

ABSTRACT
Early phase diabetes is often accompanied by pain sensitization. In Drosophila, the insulin receptor (InR) regulates the persistence of injury-induced thermal nociceptive sensitization. Whether Drosophila InR also regulates the persistence of mechanical nociceptive sensitization remains unclear. Mice with a sensory neuron deletion of the insulin receptor (Insr) show normal nociceptive baselines; however, it is uncertain whether deletion of Insr in nociceptive sensory neurons leads to persistent nociceptive hypersensitivity. In this study, we used fly and mouse nociceptive sensitization models to address these questions. In flies, InR mutants and larvae with sensory neuron-specific expression of RNAi transgenes targeting InR exhibited persistent mechanical hypersensitivity. Mice with a specific deletion of the Insr gene in Nav1.8+ nociceptive sensory neurons showed nociceptive thermal and mechanical baselines similar to controls. In an inflammatory paradigm, however, these mutant mice showed persistent mechanical (but not thermal) hypersensitivity, particularly in female mice. Mice with the Nav1.8+ sensory neuron-specific deletion of Insr did not show metabolic abnormalities typical of a defect in systemic insulin signaling. Our results show that some aspects of the regulation of nociceptive hypersensitivity by the insulin receptor are shared between flies and mice and that this regulation is likely independent of metabolic effects.
The fission yeast cytokinetic ring component Fic1 promotes septum formation
Authors: Rossi Anthony M. , Bohnert K. Adam , Gould Kathleen L. 
Published: May 2023

ABSTRACT
In Schizosaccharomyces pombe, septum formation is coordinated with cytokinetic ring constriction but the mechanisms linking these events are unclear. In this study, we explored the role of the cytokinetic ring component Fic1, first identified by its interaction with the F-BAR protein Cdc15, in septum formation. We found that the fic1 phospho-ablating mutant, fic1-2A, is a gain-of-function allele that suppresses myo2-E1, the temperature-sensitive allele of the essential type-II myosin, myo2. This suppression is achieved by the promotion of septum formation and required Fic1's interaction with the F-BAR proteins Cdc15 and Imp2. Additionally, we found that Fic1 interacts with Cyk3 and that this interaction was likewise required for Fic1's role in septum formation. Fic1, Cdc15, Imp2, and Cyk3 are the orthologs of the Saccharomyces cerevisiae ingression progression complex, which stimulates the chitin synthase Chs2 to promote primary septum formation. However, our findings indicate that Fic1 promotes septum formation and cell abscission independently of the S. pombe Chs2 ortholog. Thus, while similar complexes exist in the two yeasts that each promote septation, they appear to have different downstream effectors.
Regulation of anterior neurectoderm specification and differentiation by BMP signaling in ascidians
Authors: Roure Agnès , Chowdhury Rafath , Darras Sébastien 
Published: May 2023

ABSTRACT
The most anterior structure of the ascidian larva is made of three palps with sensory and adhesive functions essential for metamorphosis. They derive from the anterior neural border and their formation is regulated by FGF and Wnt. Given that they also share gene expression profiles with vertebrate anterior neural tissue and cranial placodes, their study should shed light on the emergence of the unique vertebrate telencephalon. We show that BMP signaling regulates two phases of palp formation in Ciona intestinalis. During gastrulation, the anterior neural border is specified in a domain of inactive BMP signaling, and activating BMP prevented its formation. During neurulation, BMP defines ventral palp identity and indirectly specifies the inter-papilla territory separating the ventral and dorsal palps. Finally, we show that BMP has similar functions in the ascidian Phallusia mammillata, for which we identified novel palp markers. Collectively, we provide a better molecular description of palp formation in ascidians that will be instrumental for comparative studies.
Myc promotes polyploidy in murine trophoblast cells and suppresses senescence
Authors: Singh Vijay Pratap , Hassan Huzaifa , Deng Fengyan , Tsuchiya Dai , McKinney Sean , Ferro Kevin , Gerton Jennifer L. 
Published: May 2023

ABSTRACT
The placenta is essential for reproductive success. The murine placenta includes polyploid giant cells that are crucial for its function. Polyploidy occurs broadly in nature but its regulators and significance in the placenta are unknown. We have discovered that many murine placental cell types are polyploid and have identified factors that license polyploidy using single-cell RNA sequencing. Myc is a key regulator of polyploidy and placental development, and is required for multiple rounds of DNA replication, likely via endocycles, in trophoblast giant cells. Furthermore, MYC supports the expression of DNA replication and nucleotide biosynthesis genes along with ribosomal RNA. Increased DNA damage and senescence occur in trophoblast giant cells without Myc, accompanied by senescence in the neighboring maternal decidua. These data reveal Myc is essential for polyploidy to support normal placental development, thereby preventing premature senescence. Our study, combined with available literature, suggests that Myc is an evolutionarily conserved regulator of polyploidy.
Oral cavity health and remedy options to stimulate epithelization of oral mucosa
Authors: Boitsaniuk Svitlana , Chorniy Sofiia , Manashchuk Nadia , Chornij Natalia , Pohoretska Khrystyna , Patskan Lyudmula , Levkiv Mariana 
Published: May 2023

Oral mucosa is an inner lining of oral cavity, which maintains different functions including protection of epithelial integrity. Pathology of oral mucosa can develop in response to the action of pathogenic microorganisms, viruses, and various traumatic factors; it can be a result of systemic pathology of a patient as well. Pain and discomfort usually accompanies such conditions leading to decrease of patient wellbeing. The basis of the pharmacological regulation of the regeneration process is the stimulation of wound healing.
The aim is to summarize and discuss the spectrum of remedy options that are used to stimulate epithelization of oral mucosa. The overall goal of the paper is to provide full and comprehensive information for dentists and their patients about medicament variety, ways of theirs application and dosage.
Methods. Relevant literature from MEDLINE (PubMed), Google Scholar, and in open access journals which are published by Elsevier was selected using the following key words «oral mucosa», «epithelization», and «remedy» were used in various combinations by the year of 2023. In total there were found 48 papers. To the selected scientific papers we applied the inclusion and exclusion criteria to choose the relevant ones.
Conclusions. A significant number of drugs for the treatment of inflammatory processes in the oral cavity are available nowadays on dental market. Numerous studies substantiates the effectiveness of their use in dentistry. Therefore, when choosing pharmacological drugs, preference is given to drugs with a complex effect, which locally affect various links of the pathogenetic mechanism of the occurrence of diseases and do not disturb human wellbeing.
Simultaneous Dimension Reduction and Variable Selection for Multinomial Logistic Regression
Authors: Wen Canhong , Li Zhenduo , Dong Ruipeng , Ni Yijin , Pan Wenliang 
Published: May 2023

Multinomial logistic regression is a useful model for predicting the probabilities of multiclass outcomes. Because of the complexity and high dimensionality of some data, it is challenging to fit a valid model with high accuracy and interpretability. We propose a novel sparse reduced-rank multinomial logistic regression model to jointly select variables and reduce the dimension via a nonconvex row constraint. We develop a block-wise iterative algorithm with a majorizing surrogate function to efficiently solve the optimization problem. From an algorithmic aspect, we show that the output estimator enjoys consistency in estimation and sparsity recovery even in a high-dimensional setting. The finite sample performance of the proposed method is investigated via simulation studies and two real image data sets. The results show that our proposal has competitive performance in both estimation accuracy and computation time. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms–Discrete. Funding: This work was supported by the National Natural Science Foundation of China [Grants 71991474, 12171449, 11801540, and 12071494] and the Natural Science Foundation of Anhui Province [Grant BJ2040170017]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/ijoc.2022.0132 .
On the Nature of (Jump) Skewness Risk Premia
Authors: Orłowski Piotr , Schneider Paul , Trojani Fabio 
Published: May 2023

Market skewness risk is priced, but the components of its premium are not fully understood. We propose new trading strategies decomposing the skewness risk premium into jump and leverage effect components, and we analyze the skewness risk premia in the market for S&P 500 index options. We find that the skewness premium is higher when markets are closed than during trading hours, consistently with uncertainty resolution patterns by non-U.S investors; that it increases after left-tail market events; and that it is distinct from the variance premium. Moreover, during trading hours, the skewness premium is dominated by priced jump risk. This paper was accepted by Kay Giesecke, finance. Funding: P. Orłowski acknowledges financial support from the Doc.Mobility program of the Swiss National Science Foundation [Project P1TIP1_161875 “Option portfolio returns and dispersion”]. P. Schneider acknowledges financial support from the Swiss National Science Foundation [Projects 169582 “Model-free asset pricing” and 189086 “Scenarios”]. F. Trojani and P. Orłowski acknowledge financial support from the Swiss National Science Foundation [Project 150198 “Higher order robust resampling and multiple testing methods”] and the Swiss Finance Institute [Project “Term structures and cross-sections of asset risk premia”]. F. Trojani gratefully acknowledges support from the AXA Chair in Socioeconomic Risks of Financial Markets at the University of Turin. Supplemental Material: The data files and online appendices are available at https://doi.org/10.1287/mnsc.2023.4734 .
Impoliteness in Jeremy Clarkson’s humor in the tv series Top Gear
Authors: Elkholy Elkholy , Ahsani Nizam 
Published: May 2023

This research was conducted to observe impoliteness strategies employed by Jeremy Clarkson in his humor in the TV Series Top Gear with the intention to unveil which strategy he utilized most and elucidate the reason upon the most and least occurring impoliteness strategies. The present research utilizes Culpeper’s (1996) model of impoliteness super strategies as the main framework to identify, analyze, and elaborate the research data. Other theories related to impoliteness such as face-threatening act and politeness was also utilized to assist the analysis process. The result of the research revealed that negative impoliteness strategy was the most commonly used strategy through which Jeremy Clarkson delivers his humor. Contrary to the withhold politeness strategy which accounted for the least occurring strategy. The explanation upon the result to be the way they are could be referred back to Jeremy Clarkson’s main intentions of uttering impolite remarks—in an effort to amuse the audience and keep the show entertaining.
Implicações da Pandemia para a Psicologia nas Políticas Públicas
Authors: Costa Pedro Henrique Antunes da , Meneses Amanda Figueiredo Falcomer , Silva Júnior Antonio Juvenal da , Pinto Débora Ferreira Couto , Oliveira João Gabriel Carvalho Araújo Mello de , Carvalho Marília Batista , Corrêa Otto Leone , Andrade Soraya Souza de , Mendes Kíssila Teixeira , Ronzani Telmo Mota 
Published: May 2023

O artigo objetivou identificar e analisar desafios e potencialidades no trabalho de psicólogas(os) nas políticas públicas brasileiras na conjuntura pandêmica. É um estudo exploratório-descritivo de abordagem mista. A coleta de dados foi realizada por meio de questionário virtual com 123 psicólogas(os) que trabalhavam nas políticas públicas no país. A análise se deu a partir da extração de medidas de tendência central e pela Análise de Conteúdo temática, em um diálogo da psicologia com a tradição marxista. Os resultados apontaram para os efeitos deletérios objetivos e subjetivos do sucateamento das políticas às(aos) profissionais, bem como o tolhimento de suas práticas. Por outro lado, também apontaram algumas potencialidades que contradizem a si próprias(os) e à realidade. Fica a premência de responsabilização do Estado em fornecer melhores condições de trabalho e fortalecer as políticas públicas para o enfrentamento à pandemia, assim como a necessidade de reflexão e transformação da psicologia e sua práxis.
Efeitos da Intervenção Relaxamento, Imagens Mentais e Espiritualidade em Pacientes com Diagnóstico de Câncer
Authors: Jesus Daiane Linz da Silva de , Silva Bruna Fernanda da , Bellinati Natalia Veronez da Cunha 
Published: May 2023

O câncer é considerado uma das principais doenças no mundo, e diversas estratégias vêm sendo utilizadas para amenizar suas consequências negativas. A intervenção Relaxamento, Imagens Mentais e Espiritualidade é um potencial meio para a melhoria do bem-estar dos pacientes. Portanto, o presente estudo objetivou identificar possíveis efeitos dessa intervenção em pacientes acometidos pelo câncer. Assim, realizou-se uma revisão integrativa da literatura. A busca de artigos ocorreu em agosto de 2020 nas bases de dados: Biblioteca Virtual em Saúde, SciELO, PubMed e Google Acadêmico. Os Descritores em Ciências da Saúde estabelecidos foram: "Relaxamento", "Imagens Mentais", "Espiritualidade" e "Câncer", em português e inglês, identificados no título, resumo ou palavras-chave. Foram considerados artigos em português e/ou inglês com texto completo disponível, dissertações e/ou teses, sem limite de ano de publicação. A busca resultou em 948 estudos. Desses, foram descartados: 424 pelos critérios de exclusão, e 500 com base na leitura dos títulos e resumos. Sete estudos foram selecionados para revisão, obtendo-se três categorias finais: transformação da dor simbólica da morte; benefícios no aspecto físico dos pacientes; benefícios no aspecto psicológico dos pacientes. A intervenção Relaxamento, Imagens Mentais e Espiritualidade oferece cuidado integral, sendo considerada benéfica para pacientes oncológicos, mesmo associada aos tratamentos convencionais.
Albores de la Psicología Formal en Puerto Rico: Pléyade de Influencias (1900-1934)
Authors: Torres Irma Roca de 
Published: May 2023

Este artigo apresenta as biografias de nove profissionais que contribuíram ao desenvolvimento da Psicologia em Porto Rico e que fazem parte da The Palgrave Biographical Encyclopedia of Psychology in Latin America, organizada por Ana Maria Jacó-Vilela, Hugo Klappenbach y Rubén Ardila, com publicação planejada para 2023. A contribuição de Porto Rico a esta Enciclopédia inclui biografias de 54 profissionais que forneceram a base para a formação acadêmica em Psicología no país. A pesquisa por estes profissionais teve início ainda no século XX, com o desenvolvimento do ensino universitário de Psicologia no país em 1900, com a fundação da Universidad de Puerto Rico, a primeira universidade criada no país. São apresentados alguns dados das trajetórias de nove professores/as universitários/as pioneiros/as, suas formações acadêmicas, as profissões em que se formaram e atuaram e as múltiplas perspectivas teóricas e visões que trouxeram para a Psicologia. Os psicólogos e psicólogas que incluí neste artigo são: Domingo Rubio Arana, Charles W. St. John, Juan B. Soto, Fred C. Walters, Malvina Monefeldt, Alfredo Silva Cofresí, Néstor I. Vincenty, Ana María O'Neill e Teobaldo Casanova.
Childhood obesity: A societal safeguarding concern?
Authors: Cusack Philippa 
Published: May 2023

Background: Safeguarding referrals into the multi-agency safeguarding hubs (MASH) for overweight or clinically obese children are increasing, in line with national and global statistics. Childhood obesity reduces physical and mental health, social and education outcomes, and quality of life, all of which can last into adulthood. Aims: To explore if childhood obesity is a societal safeguarding concern. Method: A systematic literature search, using the following keywords: obese* child* safeguard*, child protection, BMI, adolescen* and youth. was employed using electronic databases. Findings: Substantial numbers of children are not meeting recommendations on daily physical activity, compounded by increased screen time. Current family therapies and lack of collaboration between services are not able to address childhood obesity. Conclusions: Childhood obesity is a societal multi-factorial safeguarding issue, requiring a holistic, collaborative approach. This could include bespoke collaborative interventions to increase self-determination in families throughout lifespan and protection of open and green spaces in education settings, for example.
Prediction of serious complications in patients with pulmonary thromboembolism and solid cancer: Validation of the EPIPHANY Index in a prospective cohort of patients from the PERSEO study
Authors: Sánchez-Cánovas Manuel , Jimenez-Fonseca Paula , Fernández Garay David , Cejuela Solís Mónica , Casado Elía Diego , Coma Salvans Eva , de la Haba Vacas Irma , Gómez Sánchez David , Fernández Montés Ana , Morales Giménez Roberto , Biosca Gómez de Tejada Mercedes , Arrazubi Arrula Virginia , Sequero López Silvia , Otero Candelera Remedios , Sánchez Cendra Cristina , Justo de la Peña Marina , Moreno Muñoz Diana , Orillo Sarmiento Mayra , Martínez de Castro Eva , García Escobar Ignacio , Bernal Vidal Alejandro , Ortega Moran Laura , Muñoz Martín Andrés J. , Sánchez Bayona Rodrigo , Martínez Ortiz María José , Ayala de la Peña Francisco , Vicente Vicente , Carmona-Bayonas Alberto 
Published: May 2023

Introduction
There is currently no validated score capable of classifying cancer-associated pulmonary embolism (PE) in its full spectrum of severity. This study has validated the EPIPHANY Index, a new tool to predict serious complications in cancer patients with suspected or unsuspected PE.

Method
The PERSEO Study prospectively recruited individuals with PE and active cancer or receiving antineoplastic therapy from 22 Spanish hospitals. The estimation of the relative frequency θ of complications based on the EPIPHANY Index categories was made using the Bayesian alternative for the binomial test.

Results
A total of 900 patients, who were diagnosed with PE between October 2017 and January 2020, were enrolled. The rate of serious complications at 15 days was 11.8%, 95% highest density interval [HDI], 9.8–14.1%. Of the EPIPHANY low-risk patients, 2.4% (95% HDI, 0.8–4.6%) had serious complications, as did 5.5% (95% HDI, 2.9–8.7%) of the moderate-risk participants and 21.0% (95% HDI, 17.0–24.0%) of those with high-risk episodes. The EPIPHANY Index was associated with overall survival (OS) in patients with different risk levels: median OS was 16.5, 14.4, and 4.4 months for those at low, intermediate, and high risk, respectively. Both the EPIPHANY Index and the Hestia criteria exhibited greater negative predictive value and a lower negative likelihood ratio than the remaining models. The incidence of bleeding at 6 months was 6.2% (95% HDI, 2.9–9.5%) in low/moderate-risk vs 12.7% (95% HDI, 10.1–15.4%) in high-risk (p-value = 0.037) episodes. Of the outpatients, serious complications at 15 days were recorded in 2.1% (95% HDI, 0.7–4.0%) of the cases with EPIPHANY low/intermediate-risk vs 5.3% (95% HDI, 1.7–11.8%) in high-risk cases.

Conclusion
We have validated the EPIPHANY Index in patients with incidental or symptomatic cancer-related PE. This model can contribute to standardize decision-making in a scenario lacking quality evidence.