bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mucinous tumors arising from ovarian teratomas as another source of pseudomyxoma peritoneii: MR findings comparison with ovarian metastases from appendiceal mucinous tumors
Authors: Tanaka Yumiko Oishi , Sugawara Emiko , Tonooka Akiko , Saida Tsukasa , Sakata Akiko , Fukunaga Yosuke , Kanao Hiroyuki , Satoh Toyomi , Noguchi Masayuki , Terauchi Takashi 
Published: March 2023

Objective: The origin of pseudomyxoma peritoneii (PMP) has been established as low-grade appendiceal mucinous tumors (AMT). However, intestinal-type ovarian mucinous tumors are known as another source of PMP. Recently, it is advocated that ovarian mucinous tumors causing PMP originates from teratomas. However, AMTs are often too small to detect on imaging; then, differentiating metastatic ovarian tumors of AMT from ovarian teratoma-associated mucinous tumors (OTAMT) is important. Therefore, this study investigates the MR characteristics of OTAMT compared to the ovarian metastasis of AMT. Methods: MR findings of six pathologically confirmed OTAMT were retrospectively analyzed compared to ovarian metastases of low-grade appendiceal mucinous neoplasms (LAMN). We studied the existence of PMP, uni- or bilateral disease, the maximum diameter of ovarian masses, the number of loculi, a variety of sizes and signal intensity of each content, the existence of the solid part, fat, calcification within the mass, and appendiceal diameters. All the findings were statistically analyzed using the Mann–Whitney test. Results: Four of the six OTAMT showed PMP. OTAMT showed unilateral disease, had a larger diameter, more frequent intratumoral fat, smaller appendiceal diameter than those in AMT, and they were statistically significant (p < .05). On the other hand, the number, variety of size, signal intensity of loculi, and the solid part, calcification within the mass did not differ from each other. Conclusion: Both OTAMT and ovarian metastasis of AMT appeared as multilocular cystic masses with relatively uniform signal and size of loculi. However, a larger unilateral disease with intratumoral fat and smaller size of the appendix may suggest OTAMT. Advances in knowledge: OTAMT can be another source of PMP, as AMT. MR characteristics of OTAMT were very similar to ovarian metastases of AMT; however, in cases with PMP combined with fat-containing multilocular cystic ovarian mass, we can diagnose them as OTAMT, not PMP caused by AMT.
Relationship between IDH1/2 and TERT promoter mutation and the prognosis of human glioma patients
Authors: Liu Xiping , Liu Ming , Cao Bing , Qiao Jianxin , Zhang Xiufeng 
Published: March 2023

Objective: To investigate the relationship between isocitrate dehydrogenase (IDH) 1/2 mutation, telomerase reverse transcriptase (TERT) gene promoter mutation and the prognosis of human glioma patients.
Methods: One hundred fifteen patients with human glioma, treated surgically in The First Affiliated Hospital of Hebei North University from January 2019 to January 2020, were included. All patients were followed up until January 31, 2022. The mutations of IDH1/2 and TERT promoter were analyzed, and risk factors affecting survival of the patients with glioma were assessed.
Results: IDH1 gene mutation occurred in 82 cases, IDH2 gene mutation occurred in five cases and TERT promoter mutation occurred in 54 cases. Univariate analysis showed that tumor WHO grade, resection range, preoperative Karnofsky performance status score, postoperative radiotherapy and chemotherapy, IDH1/2 gene and TERT promoter mutation influenced postoperative survival of patients with glioma (P<0.05). Kaplan-Meier survival curve showed that IDH1/2 gene and TERT promoter mutation were significantly different from those of wild-type patients (P<0.05).
Conclusion: IDH1/2 gene and TERT promoter mutations are more frequent in patients with human glioma. These related factors can be used as molecular markers to aid in the prognosis of patients with glioma.
doi: https://doi.org/10.12669/pjms.39.3.7149
How to cite this: Liu X, Liu M, Cao B, Qiao J, Zhang X. Relationship between IDH1/2 and TERT promoter mutation and the prognosis of human glioma patients. Pak J Med Sci. 2023;39(3):843-847. doi: https://doi.org/10.12669/pjms.39.3.7149
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Efficacy and safety of surfactant administration by MIST and INSURE techniques in Neonates with Respiratory Distress Syndrome: A randomized controlled trial
Authors: Kaleem Ammara , Farah Haroon  , Bushra Fatima  , Gideon Victor  , Mazhar Qadir  , Khawaja Ahmed Irfan Waheed1  
Published: March 2023

Objective: To measure the efficacy and safety of surfactant administered by MIST and INSURE to neonates with respiratory distress syndrome.
Methods: A randomized controlled trial was conducted from June 2021 to August 2022 at the NICU of the University of Child Health Sciences, Lahore. Neonates meeting inclusion criteria i.e with RDS who worsened on nasal Continuous positive airway pressure (nCPAP) (fiO2 30%, pressure 6cmH2O) were enrolled in the study in both interventional arms (MIST, n=36 and INSURE, n=36) using simple random sampling. Data was analysed using SPSS 25.
Results: The mean age of neonates in MIST was 1.27±0.40 days and 1.23±0.48 days in INSURE cohort. Neonates with MIST (n=8) required statistically significant reduced need for IMV than INSURE (n=17) technique (P-Value 0.047). This study could not achieve significant difference in duration of mechanical ventilation (1±1.67; 1.52±1.40 days, P=0.152) and duration of nCPAP (3.27±1.65;3.67±1.64 hrs, P=0.312) in MIST versus INSURE. The second dose of surfactant was administered in fewer cases in MIST (n=2) than INSURE (n=7) (P=0.075). Risk estimation, although not significant, determined less likelihood for the pulmonary haemorrhage (0.908 than 1.095), intraventricular hemorrhage (0.657 than 1.353), administration of the second dose of surfactant (0.412 than 1.690) and greater likelihood of discharge (1.082 than 0.270) at 95% confidence interval with MIST technique.
Conclusion: Surfactant therapy through MIST is effective and there is significantly reduced need of IMV than in INSURE. Safety profile though could not achieve statistical significance yet determines less risk of complications associated with MIST than INSURE.
doi: https://doi.org/10.12669/pjms.39.3.7283
How to cite this: Kaleem A, Haroon F, Fatima B, Victor G, Qadir M, Waheed KAI. Efficacy and safety of surfactant administration by MIST and INSURE techniques in Neonates with Respiratory Distress Syndrome: A randomized controlled trial. Pak J Med Sci. 2023;39(3):848-852. doi: https://doi.org/10.12669/pjms.39.3.7283
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copy number variations and protein expression of Cyclin E1 and Epithelial cell transforming sequence 2 genes predict the chemotherapeutic response in patients with serous ovarian carcinoma
Authors: Sarfaraz Rahat , Masood Atika , Zaki Saima , Shami Amira , Khaliq Saba , Naseem Nadia 
Published: March 2023

Background & Objectives: Serous ovarian carcinoma (SOC) is characterized by extreme genomic instability, chromosomal rearrangements and copy number variations (CNVs) leading to the development of early metastasis and chemo-resistance. The present study was designed to observe the role of CNVs of Cyclin E1 (CCNE1) and Epithelial cell transforming sequence- 2 (ECT2) genes and their encoded proteins in predicting the chemotherapeutic response in SOC patients.
Methods: This observational analytical study was conducted at University of Health Sciences, Lahore, Pakistan from December 2019 till June 2022.The study included twenty-five SOC patients with resectable ovarian tumors and twenty-five control subjects. The patients were followed-up for six months for their response to chemotherapy. The CNVs in CCNE1 and ECT-2 genes were determined by real time PCR while serum levels of encoded proteins were determined in controls and cases, before and after six months of treatment, through ELISA. The response to chemotherapy was categorized as sensitive or resistant based on serum CA-125 levels and radiological scans.
Results: The copy number variations in CCNE1 and ECT2 genes showed association with the clinic-pathological characteristics and chemotherapy response. Statistically significant difference was found between the mean pre-chemotherapy protein levels of CCNE1 in cases than controls (p-value <0.001) and between the mean pre and post-chemotherapy protein levels of CCNE1 and ECT2 (p-value <0.001) in SOC patients.
Conclusion: The copy number variations of CCNE1 and ECT2 genes and their protein expression are positively associated with chemotherapeutic response in SOC patients.
doi: https://doi.org/10.12669/pjms.39.3.7304
How to cite this: Sarfraz R, Masood A, Zaki S, Shami A, Khaliq S, Naseem N. Copy number variations and protein expression of Cyclin E1 and Epithelial cell transforming sequence 2 genes predict the chemotherapeutic response in patients with serous ovarian carcinoma. Pak J Med Sci. 2023;39(3):835-842. doi: https://doi.org/10.12669/pjms.39.3.7304
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Participação nas aulas de Educação Física em Pernambuco: uma análise de tendência temporal
Authors: Soares Mallu Dias , Simão Maria Júlia de Freitas Lourenço e , Soares Fernanda Cunha , Barbosa Filho Valter Cordeiro , Tassitano Rafael Miranda , Bezerra Jorge 
Published: March 2023

O objetivo do estudo foi analisar a tendência temporal e fatores associados à participação nas aulas de educação física de estudantes de Pernambuco. Estudo de tendência temporal composto por três levantamentos de abrangência estadual. Foram entrevistados 4.207 estudantes em 2006, 6.264 em 2011 e 6.002 em 2016, por meio do questionário “Global School-based Student Health Survey” (GSHS). O desfecho foi a participação nas aulas de Educação Física e as exposições foram as informações sociodemográficas. A análise bivariada foi realizada mediante teste Qui-quadrado e as análises multivariadas por regressão logística binária. Observou-se um aumento na prevalência de participação nas aulas de Educação Física (2006: 35%, 2011: 74% e 2016: 81,2%) destacando o aumento significativo no sexo masculino Δ% (2006-2016) = 123,5%. Ser do sexo masculino, estudar no período integral e ser filho de mães que estudaram, independente do tempo de estudo foi associado a maior participação nas aulas de educação física, assim como residir nas regiões do Agreste, Sertão e Sertão do São Francisco. Apesar do aumento na participação nas aulas de Educação Física em Pernambuco, a garantia deste componente curricular deve ser fortalecida, levando em consideração os grupos de risco para que aumente a participação nas aulas desses grupos.
Persuading Risk-Conscious Agents: A Geometric Approach
Authors: Anunrojwong Jerry , Iyer Krishnamurthy , Lingenbrink David 
Published: March 2023

A Convex Programming Framework for Information Design Under Realistic Human Behavior Platform markets and services typically have additional relevant information in comparison with their users. Information design studies how the sharing of this information can be leveraged by the platform to influence user behavior and obtain desirable outcomes. Previous research has studied information design assuming that the users act to maximize their expected utility, but this assumption does not always hold in reality. Instead, people often exhibit biases and deviations from expected utility maximization. In “Persuading Risk-Conscious Agents: A Geometric Approach,” Anunrojwong, Iyer, and Lingenbrink study information design with “risk-conscious” agents whose utility functions may depend nonlinearly on their beliefs. They provide a convex programming approach for solving for the optimal persuasion mechanism and establish their structural properties in different settings. They illustrate their approach in an application involving the sharing of waiting-time information in a queueing system. Overall, this work contributes to the study of information design under realistic models of human behavior.
The Fundamental Recruitment Error: Candidate-Recruiter Discrepancy in Their Relative Valuation of Innate Talent vs. Hard Work
Authors: Dai Xianchi , Si Kao 
Published: March 2023

Innate talent and orientation toward hard work are highly important personal attributes with respect to workers’ productive capabilities. In this research, we identify a discrepancy between job candidates and recruiters in their relative valuation of these two attributes. Although innate talent is valued relatively more by job candidates than recruiters, the opposite is true for orientation toward hard work. We propose that the discrepancy is rooted in a misalignment of the fundamental motivations of the two parties in the job market. In seven studies (four preregistered), which include randomized trial experiments and quasi-experiments and use real life recruiters and job seekers (across a total of 112 industries) as participants, we provide evidence of the current effect and its underlying mechanism. Studies 1A–1C demonstrate the negative consequence of the discrepancy on job market efficiency, showing that it can lead candidates to adopt impression management strategies that lower their chance of getting the job. Studies 2A and 2B show that full-time workers consider career potential to be associated with both innate talent and hard work but position performance to be more strongly associated with hard work than innate talent. Finally, Studies 3A and 3B indicate that candidates are relatively more career-focused, whereas recruiters are relatively more position focused and that this difference in their relative focus mediates the current discrepancy. Implications of the present research for both job candidates and recruiters are discussed. Funding: This research was supported by the National Natural Science Foundation of China General Program [Grant 72172136] awarded to X. Dai and University of Macau Multi-Year Research Grants [MYRG2020-00030-FBA and MYRG2022-00126-FBA] awarded to K. Si. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2023.1667 .
MUDANÇAS DOS FATORES DE RISCO E PROTEÇÃO PARA DOENÇAS CRÔNICAS NÃO TRANSMISSÍVEIS DURANTE O ISOLAMENTO SOCIAL DETERMINADO PELA PANDEMIA DO COVID-19
Authors: Peter Grillo Luciane , Elíbio Fagundes Gabriela , Theilacker Giulia 
Published: March 2023

As Doenças Crônicas Não Transmissíveis configuram como importante problema de saúde pública no Brasil e no mundo. Objetivo: Avaliar as alterações dos fatores de risco e proteção para doenças crônicas durante o isolamento social determinado pela pandemia do COVID-19. Métodos: População universitária avaliada por meio de um questionário online validado. Resultados: Nos acadêmicos (n=46) encontrou-se predominância do sexo feminino (76%), estado nutricional eutrofia antes e depois, respectivamente (46% e 56%), diminuição da atividade física (46%, 24%), aumento em assistir TV (9%, 13%) e uso de eletrônicos por mais de 3h (65%, 96%) e estado de saúde atual regular (52%). Nos docentes (n=11) predominou o sexo feminino (64%), estado nutricional eutrofia antes e depois, respectivamente (73% e 64%), diminuição no consumo de hortaliças (64%, 36%), aumento em assistir TV (18%, 36%) e uso de eletrônicos por mais de 3h (90%, 100%) e estado de saúde atual como bom (64%). Conclusão: Necessidade de ações institucionais que contribuam para a redução dos fatores de riscos e privilegiem os de proteção para este grupo de doenças.
IMPACTO DAS RECOMENDAÇÕES DE SAÚDE DURANTE A PANDEMIA DA COVID-19 NAS HOSPITALIZAÇÕES POR DOENÇAS RESPIRATÓRIAS NO BRASIL: UM ESTUDO DE VIGILÂNCIA EPIDEMIOLÓGICA NACIONAL
Authors: Oliveira Laiane Krech , De Olievira Vinícius da Silva Lessa , Bagatini Maria Amélia , Heinzmann-Filho João Paulo 
Published: March 2023

Introdução: A pandemia da COVID-19 é um dos maiores desafios de saúde pública, visto que acarretou mudanças na rotina pessoal, social e na mobilidade urbana da população.Objetivo: Avaliar o impacto das recomendações de saúde para o controle da COVID-19 sobre as hospitalizações por doenças respiratórias no Brasil.Métodos: Trata-se de um estudo ecológico, utilizando informações disponíveis na base de dados do Departamento de Informática do SUS. Foram utilizados dados de indivíduos de todas as idades e sexo que internaram devido às doenças do aparelho respiratório no SUS, em todas as regiões brasileiras. Estes dados foram obtidos de março até agosto de cada ano, percorrendo o período de 2015-2019 e de 2020 (medidas para o controle da COVID-19). Para fins estatísticos, utilizou-se análise descritiva.Resultados: Totalizaram-se 3.317.081 milhões de hospitalizações no Brasil por doenças do aparelho respiratório entre 2015 e 2019, correspondendo uma média de 663.416 internações/ano (taxa: 41,57/10 mil habitantes). Embora pareça haver estabilidade (oscilação <±15%) neste indicador ao longo de 2015/2019, observou-se expressiva redução (absoluta: -50% até -65%; taxa: -48,22% e -61,93%) destas hospitalizações em todas as regiões do país, quando analisado com o mesmo período do ano de 2020 (medidas de controle da COVID-19). As localidades com maiores reduções nas taxas foram a Sudeste, Centro-Oeste e a Norte. Além disso, estes desfechos foram mais elevados nos homens e no grupo etário idoso.Conclusão: As medidas de saúde recomendadas para o controle da COVID-19 causaram redução das hospitalizações no SUS por doenças do aparelho respiratório no Brasil. Palavras-chave: Prevenção de Doenças, Infecções por Coronavirus, Pandemias, Doenças respiratórias, Hospitalização.
Evolution of the Lamellar Pearlite Structure of Rail Steel under Tension
Authors: Aksenova K.V. , Gromov V.E. , Ivanov Yu.F. , Vaschuk E.S. , Porfiriev M.A. 
Published: March 2023

In this paper, the properties of rail steel subjected to fracture under uniaxial tension deformation are studied. Mechanical properties of rail steel, defective substructure of lamellar pearlite, and fracture surface of rail steel are investigated using methods of modern physical materials science.
Tensile strength is found to vary from 1247 to 1335 MPa, and the fracture strain of the samples changes from 0.22 to 0.26. The deformation of the rail steel is accompanied by the process of breaking the ferrite plates into fragments by low angle boundaries along with the significant increase in the scalar dislocation density to 7.9-1010 cm-2 (the scalar dislocation density of the original rail steel is 3.2 -1010 cm-2). Also, there is a formation of internal stress fields appearing in the form of bend extinction contours. The sources of stress fields are identified. It is revealed that cementite plates are fractured by cutting and dissolution with subsequent transfer of carbon to ferrite plates by moving dislocations and formation of round-shaped nanodimensional (8.3 nm) round shaped particles of tertiary cementite. It is shown that the dissolution of cementite plates is accompanied by fragmentation (into coherent scattering regions with an average size of 9.3 nm).
Deterministic Interpretation of the Malus Law and Correlation in Experiments with Entangled Photons
Authors: Гончаров Александр Иванович 
Published: March 2023

This paper examines a local deterministic model of an experiment involving correlated photons. The experimental setup involves a source that emits two linearly polarized photons in each act, two two-channel analyzers, and detectors included in the coincidence scheme. The orientation angle of the photon polarization plane is a random variable with a uniform distribution, and it is the same for simultaneously emitted photons. The model presented here is a generalization of the “naive example of hidden variable theory” described in A. Aspect's article ‘Bell's Theorem: The Naive View of an Experimentalist.
In our model, the outcome of the photon interaction with the analyzer (hit in one of the two channels) is uniquely determined by the angle between the photon polarization plane and the analyzer axis and is described by a step function. The difference in our model is that the step function contains a large number of segments of different lengths. The location and lengths of the segments are set so that the probability of a photon hitting a specific channel of an ideal analyzer, determined by averaging the outcomes over small neighborhoods of angles, approaches the Malus law when the maximum length of a segment decreases. This ensures that the classical model is self-consistent.
When ideal analyzers are used, the absolute value of the correlation coefficient of detector readings mainly does not exceed the values from Aspect's ‘naive example’. However, when analyzers with absorption are used, the calculated correlations for some orientations of the analyzers exceed the quantum mechanical values. Key words: linear polarization of photons, Malus law, entangled photons, correlations, hidden parameters.
On the Geometry of Almost Quasi-Para-Sasakian Manifolds Equipped with a Canonical N-Connection
Authors: Galaev S.V. , Kokin E.A. 
Published: March 2023

This paper introduces the concept of an almost quasi-para-Sasakian manifold, which differs from the previously known quasi-para-Sasakian structure in that it is not a normal structure. Instead, it possesses a weaker property called almost normality, similar in properties to integrable tensor structures. Several examples are given, including an almost quasi-para-Sasakian structure defined on the distribution of zero curvature of a sub-Riemanni-an manifold of contact type.
An extended connection with skew-symmetric torsion is defined on an almost quasi-para-Sasakian manifold, which is unique and defined using an intrinsic connection and an endomorphism that preserves the distribution of an almost (para-)contact manifold. The paper proves that the extended connection is a metric connection, and it is also demonstrated that an almost quasi-para-Sasakian manifold can be an n-Einstein manifold with respect to an extended connection with skew-symmetric torsion, provided certain conditions are met.
Cluster Partitions Optimization Using the Latent Class Analysis Technique
Authors: Dronov S.V. 
Published: March 2023

The paper explores the formation of a cluster partition using a system of bundles of vectors. Each object is represented by a vector with coordinates corresponding to its characteristic factors. The study focuses on the principles of changes in the total density of these bundles when objects move from one cluster to another. Based on the findings, an algorithm is proposed to reduce the total intracluster variance of the initial cluster partition.
The proposed algorithm is based on a modern technique for analyzing latent classes. This technique emphasizes that the forming factors of objects within each cluster should be highly correlated. Since the number of forming factors is arbitrary, the algorithm replaces this requirement with the maximum possible proximity of object factor vectors to the average vector within each cluster. The degree of this closeness is referred to as the tightness of the cluster vector bundle.
The paper also introduces a new method for quantifying clusters in the improvable clustering constructed using the proposed algorithm. A practical example of the algorithm's application to process medical data is presented. The study discusses the reasons for the dependence of the algorithm's outcome on the choice of initial cluster partition.