bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between serum lipid profiles and cognitive impairment in old age: a cross-sectional study
Authors: Yu Yafu , Yan Pingting , Cheng Guirong , Liu Dan , Xu Lang , Yang Mengliu , Xu Heng , Cheng Xi , Lian Pengfei , Zeng Yan 
Published: April 2023

BackgroundThe correlation between cognitive function and lipid profiles, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides, is inconsistent.AimsThis cross-sectional study investigated the association between serum lipid levels and the prevalence of cognitive impairment among community-dwelling older adults and explored this difference in association by gender and urban-rural residency.MethodsParticipants aged 65 and above in urban and rural areas were recruited between 2018 and 2020, selected from the Hubei Memory and Aging Cohort Study. Detailed neuropsychological evaluations, clinical examinations and laboratory tests were conducted in community health service centres. Multivariate logistic regression was used to analyse the correlation between serum lipid profiles and the prevalence of cognitive impairment.ResultsWe identified 1 336 cognitively impaired adults (≥65 years)—1 066 with mild cognitive impairment and 270 with dementia—from 4 746 participants. Triglycerides level was correlated with cognitive impairment in the total sample (χ2=6.420, p=0.011). In gender-stratified multivariate analysis, high triglycerides in males reduced the risk of cognitive impairment (OR: 0.785, 95% CI: 0.623 to 0.989, p=0.040), and high LDL-C in females increased the risk of cognitive impairment (OR: 1.282, 95% CI: 1.040 to 1.581, p=0.020). In both gender-stratified and urban-rural stratified multivariate analyses, high triglycerides reduced the risk of cognitive impairment in older urban men (OR: 0.734, 95% CI: 0.551 to 0.977, p=0.034), and high LDL-C increased the risk of cognitive impairment in older rural women (OR: 1.830, 95% CI: 1.119 to 2.991, p=0.016).ConclusionsThere are gender and urban-rural differences in the correlation of serum lipids with cognitive impairment. High triglycerides levels may be a protective factor for cognitive function in older urban men, while high LDL-C levels may be a risk factor for cognitive function in older rural women.
Forested wetlands in a protected area and the adjacent working landscape provide complementary biodiversity value based on breeding birds: A case study from Nova Scotia, Canada
Authors: Brazner John , Walker Jake , Mackinnon Frances , Cameron Rob 
Published: April 2023

Protected areas (PAs) are a key component of most conservation strategies because they are thought to enhance biodiversity value relative to similar habitats in working landscapes. To examine whether PAs in Nova Scotia are functioning to enhance the biodiversity value of the landscapes in which they are embedded, we surveyed breeding bird communities in forested wetlands inside and outside of a large PA during 2018 and 2019. We found significantly higher species richness and diversity at sites in the working landscape relative to those inside the PA. Bird communities from different wetland types inside the PA were distinct from each other and those outside the PA, whereas bird communities at outside sites were homogenized and comprised of more early-successional species. There were numerous species of conservation concern at both inside and outside sites, indicating that both types of sites are playing important conservation roles. Abundances of these key species were driven by a combination of local (e.g., water table depth, herb, and shrub cover) and landscape scale factors (e.g., edge density and human disturbance). The higher abundance of long-distance migrants and insectivores at inside sites suggests PAs are providing critical additional support to key guilds that are in steep decline.
Riding the Seesaw: what Higgsstrahlung may reveal about massive neutrinos
Authors: Felkl Tobias , Lackner Adam , Schmidt Michael 
Published: April 2023

AbstractWe investigate if the projected high-precision measurements of the cross section of the Higgsstrahlung process $$e^+ e^- \rightarrow Zh$$

e
+

e
-

→
Z
h

at a future electron–positron collider can be utilised to indirectly probe the fermionic Seesaw models. We consider the two centre-of-mass energies $$\sqrt{s}=240$$

s

=
240

GeV and 365 GeV, and compare the collider reaches to constraints from electroweak observables, probes of lepton flavour universality and the existing and prospective bounds from searches for lepton flavour violation. For the analysis we assume the limit of an exactly conserved lepton-number symmetry. We find that while any appreciable correction to the Higgsstrahlung cross section is already strictly constrained in the Type-I Seesaw model, effects of up to $${\mathcal {O}}(10\%)$$

O
(
10
%
)

are possible within Type-III Seesaw.
CIRS: Bursting Filter Bubbles by Counterfactual Interactive Recommender System
Authors: Gao Chongming , Wang Shiqi , Li Shijun , Chen Jiawei , He Xiangnan , Lei Wenqiang , Li Biao , Zhang Yuan , Jiang Peng 
Published: April 2023

While personalization increases the utility of recommender systems, it also brings the issue offilter bubbles. e.g., if the system keeps exposing and recommending the items that the user is interested in, it may also make the user feel bored and less satisfied. Existing work studies filter bubbles in static recommendation, where the effect of overexposure is hard to capture. In contrast, we believe it is more meaningful to study the issue in interactive recommendation and optimize long-term user satisfaction. Nevertheless, it is unrealistic to train the model online due to the high cost. As such, we have to leverage offline training data and disentangle the causal effect on user satisfaction.To achieve this goal, we propose a counterfactual interactive recommender system (CIRS) that augments offline reinforcement learning (offline RL) with causal inference. The basic idea is to first learn a causal user model on historical data to capture the overexposure effect of items on user satisfaction. It then uses the learned causal user model to help the planning of the RL policy. To conduct evaluation offline, we innovatively create an authentic RL environment (KuaiEnv) based on a real-world fully observed user rating dataset. The experiments show the effectiveness of CIRS in bursting filter bubbles and achieving long-term success in interactive recommendation. The implementation of CIRS is available via https://github.com/chongminggao/ CIRS-codes.
Dual-Band Self-Complementary 5G Antenna for Wireless Body Area Network
Authors: Rahman H. M. Arifur , Shovon Md. Nakib Alam , Khan Mohammad Monirujjaman , Alanazi Turki M. 
Published: April 2023

A design of a self-complementary dual-band fifth-generation (5G) antenna for a wireless body area network (WBAN) has been presented in this paper. Like many other advantages, dual-band antennas have the benefit of being able to establish a reliable wireless connection in places that are frequently out of reach. The antenna operates at two popular 5G NR, FR-2 frequency bands: n257, or 28 GHz, and n260, or 39 GHz. FR-2 bands are prominent for high-speed data transactions within a limited range, which is perfect for WBAN applications. The proposed self-complementary single element design has a physical size of

6

mm
×
8

mm
×
1.59

mm

and is designed with a Rogers RT6002 substrate with a dielectric constant of 2.94. In free space simulations, the antenna performed satisfactorily, achieving around 90% efficiency and having return losses of 16.32 dB and 20.47 dB at the lower and upper frequency bands sequentially. The antenna generated almost omnidirectional patterns at both frequencies with a peak gain of 4.74 dB. By placing the antenna next to a 3D human torso phantom that had been digitally created with accurate human body features, the design’s onbody performance was assessed. Onbody simulations produced favorable performance with a small dispersion from their peak values in some parameters, i.e., efficiency and reflection coefficients but produced more gains: 4.34 dBi at 28 GHz and 6.19 dBi at 39 GHz. For further distance-based investigation, the antenna was placed in five different positions relative to the torso. The test yields 67% efficiency with the minimum gap and 71% at the highest distance from the human body for the lowest band. Though the lower-frequency band produces better results with more gaps, the higher-frequency band performs consistently better in even the closest placement to the human body model by reaching more than 6 dB of gain with above 81% efficiency and wider than 10 GHz of bandwidth. The overall performance indicates this design can be a good solution to complex WBAN scenarios.
Heat Exposure Following the Rainy Season Is Associated With an Increased Risk of Cardiovascular Emergency Among the Elderly in Japan
Authors: Fujimoto Ryohei , Suzuki Etsuji , Kashima Saori , Nakamura Kazufumi , Naito Hiromichi , Nakao Atsunori , Ito Hiroshi , Yorifuji Takashi 
Published: April 2023

Background
Despite the impact of heat exposure caused by global warming, few studies have investigated the hourly effects of heat exposure and the risk of cardiovascular disease (CVD) in the elderly. We examined the associations between short‐term heat exposure and the risk of CVD in the elderly in Japan and evaluated possible effect‐measure modifications by rainy seasons that occur in East Asia.

Methods and Results
We conducted a time‐stratified case–crossover study. The study included 6527 residents in Okayama City, Japan, aged ≥65 years who were transported to emergency hospitals between 2012 and 2019 for the onset of CVD during and a few months after the rainy seasons. We examined the linear associations between temperature and CVD‐related emergency calls for each year and for hourly preceding intervals before the emergency call during the most relevant months. Heat exposure during 1 month after the end of the rainy season was associated with CVD risk; the odds ratio (OR) for a 1° C increase in temperature was 1.34 (95% CI, 1.29–1.40). When we further explored the nonlinear association by using the natural cubic spline model, we found a J‐shaped relationship. Exposures 0 to 6 hours before the case event (preceding intervals 0–6 hours) were associated with CVD risk, particularly for the preceding interval 0 to 1 hour (OR, 1.33 [95% CI, 1.28–1.39]). For longer periods, the highest risk was at preceding intervals 0 to 23 hours (OR, 1.40 [95% CI, 1.34–1.46]).

Conclusions
Elderly individuals may be more susceptible to CVD after heat exposure during the month after the rainy season. As shown by finer temporal resolution analyses, short‐term exposure to increasing temperature can trigger CVD onset.
A Longitudinal Study of Acculturation in Context and Cardiovascular Health and Their Effects on Cognition Among Older Latino Adults
Authors: Lamar Melissa , Estrella Mayra L. , Capuano Ana W. , Leurgans Sue , Fleischman Debra A. , Barnes Lisa L. , Lange‐Maia Brittney S. , Bennett David A. , Marquez David X. 
Published: April 2023

Background
We previously outlined the importance of considering acculturation within the context of older Latino adults' lived experience (ie, acculturation in context) to better capture contributors to cognitive aging. We now examine this conceptual framework as related to level of and change in cardiovascular health, and whether cardiovascular health modifies previously documented associations of acculturation in context with cognition.

Methods and Results

Acculturation in context data from 192 Latino participants without dementia at baseline (age ~70 years) were compiled into 3 separate composite scores: acculturation‐related (nativity, language‐, and social‐based preferences), contextually related socioenvironmental (experiences of discrimination, social isolation, social networks), and familism‐related (Latino‐centric family ethos). A modified American Heart Association's Life's Simple 7 (mLS7; ie, smoking, physical activity, body mass index, blood pressure, total cholesterol, blood glucose) was used to measure cardiovascular health. Mixed effects regressions simultaneously tested the association of all 3 composite scores with total mLS7 adjusting for confounders. Separate models tested whether mLS7 modified associations of the 3 composite scores and cognition. The contextually related socioenvironmental composite score reflecting higher discrimination, higher social isolation, and smaller social networks (estimate=0.22, SE=0.10,
P
=0.02) and the familism score (estimate=0.16, SE=0.07,
P
=0.02) both significantly associated with change in total mLS7. The acculturation‐related composite was not significantly associated with change in mLS7. No composite was significantly associated with level of mLS7. Total mLS7, however, significantly modified associations between the acculturation‐related composite and change in working memory (estimate=−0.02, SE=0.01,
P
=0.043).

Conclusions
Acculturation within the context of older Latino adults' lived experience is important for maintaining cardiovascular health, relationships that also affect domain‐specific cognitive decline.
Relationship Between Left Ventricular Hypertrophy and Diabetes Is Likely Bidirectional: A Temporality Analysis
Authors: Lv Jiali , Liu Yang , Yan Yinkun , Sun Dianjianyi , Fan Lijun , Guo Yajun , Fernandez Camilo , Bazzano Lydia , He Jiang , Li Shengxu , Chen Wei , Zhang Tao 
Published: April 2023

Background
The temporal relationship between type 2 diabetes (T2DM) and left ventricular hypertrophy (LVH) is not well established. This study aims to examine the temporal sequence between T2DM and LVH/cardiac geometry patterns in middle‐aged adults.

Methods and Results

The longitudinal cohort consisted of 1000 adults (682 White individuals and 318 Black individuals; 41.1% men; mean age, 36.2 years at baseline) who had data on fasting glucose/T2DM, left ventricular mass index (LVMI), and relative wall thickness collected twice at baseline and follow‐up over 9.4 years on average. The cross‐lagged path analysis model in 905 adults who did not take antidiabetic medications and the longitudinal prediction model in 1000 adults were used to examine the temporal relationships of glucose/T2DM with LVMI, LVH, relative wall thickness, and remodeling patterns. After adjustment for age, race, sex, smoking, alcohol drinking, body mass index, heart rate, hypertension, and follow‐up years, the path coefficient from baseline LVMI to follow‐up glucose was 0.088 (
P
=0.005); the path from baseline glucose to follow‐up LVMI was −0.009 (
P
=0.758). The 2 paths between glucose and relative wall thickness were not significant. The path analysis parameters did not differ significantly between race, sex, and follow‐up duration subgroups. Incidence of T2DM was higher in the baseline LVH group than in the normal LVMI group (24.8% versus 8.8%;
P
=0.017 for difference). Incidence of LVH and concentric LVH was higher in the baseline T2DM group than in the group without T2DM (50.0% versus 18.2% for LVH [
P
=0.005 for difference]; 41.7% versus 12.6% for concentric LVH [
P
=0.004 for difference]), with adjustment for covariates.

Conclusions
This study suggests that the temporal relationship between T2DM and LVH is likely bidirectional. The path from LVMI/LVH to glucose/T2DM is stronger than the path from glucose/T2DM to LVMI/LVH.
Effect of Workflow Improvements on Time to Endovascular Thrombectomy for Acute Ischemic Stroke in the MR CLEAN Registry
Authors: Janssen Paula M. , Roozenbeek Bob , Coutinho Jonathan M. , van Es Adriaan C.G.M. , Schonewille Wouter J. , Lycklama a Nijeholt Geert J. , Lingsma Hester F. , Dippel Diederik W.J. ,   MR CLEAN Registry Investigators
Published: April 2023

BackgroundInsight in the effect of workflow improvements can help to minimize the time between onset of ischemic stroke and start of endovascular thrombectomy (EVT). The authors aimed to assess the implementation of EVT workflow strategies and their effect on time to treatment.MethodsThe authors used data from the MR CLEAN (Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic Stroke in The Netherlands) registry and included patients with acute ischemic stroke in the anterior circulation, who underwent EVT between March 2014 and November 2017. Data on implementation of 20 predefined workflow improvement strategies during the study period were collected from each intervention center. Multilevel linear regression with a random intercept for center was used to quantify the effect of each strategy on door‐to‐groin puncture time, with adjustment for calendar time, for directly presented and transferred patients separately.ResultsThe authors included 2633 patients who were treated in 14 intervention centers. Of the 20 predefined strategies, 18 were actually implemented in ≥1 centers during the study period. In directly presented patients (n=1157), the intervention with the largest effect on door‐to‐groin puncture time was a strategy to avoid sedation during EVT compared with standard use of general anesthesia, which led to a reduction of 29% (95% CI, 6–46;P=0.02), corresponding to a decrease of 26 minutes (95% CI, 5–42). In transferred patients (n=1476), the interventions with the largest decrease in door‐to‐groin puncture time were a strategy to make the decision for patient transfer to the angiosuite after 1 stroke physician assessed the imaging, instead of both interventionist and neurologist (47% [95% CI, 5–70]; 19 minutes [95% CI, 2–29]) (P=0.03), and a strategy to perform neurological assessment at the angiosuite instead of the emergency department (32% [95% CI, 19–43]; 13 minutes [95% CI, 8–17]) (P<0.001).ConclusionIntervention centers have implemented multiple new strategies to improve their workflow. Such workflow improvements lead to substantial reductions in time to EVT and may thereby improve the outcome of patients with acute ischemic stroke.
Association discovery and outlier detection of air pollution emissions from industrial enterprises driven by big data
Authors: Peng Zhen , Zhang Yunxiao , Wang Yunchong , Tang Tianle 
Published: April 2023

ABSTRACT
Air pollution is a major issue related to national economy and people's livelihood. At present, the researches on air pollution mostly focus on the pollutant emissions in a specific industry or region as a whole, and is a lack of attention to enterprise pollutant emissions from the micro level. Limited by the amount and time granularity of data from enterprises, enterprise pollutant emissions are still understudied. Driven by big data of air pollution emissions of industrial enterprises monitored in Beijing-Tianjin-Hebei, the data mining of enterprises pollution emissions is carried out in the paper, including the association analysis between different features based on grey association, the association mining between different data based on association rule and the outlier detection based on clustering. The results show that: (1) The industries affecting NOx and SO2 mainly are electric power, heat production and supply industry, metal smelting and processing industries in Beijing-Tianjin-Hebei; (2) These districts nearby Hengshui and Shijiazhuang city in Hebei province form strong association rules; (3) The industrial enterprises in Beijing-Tianjin-Hebei are divided into six clusters, of which three categories belong to outliers with excessive emissions of total VOCs, PM and NH3 respectively.
Treatment and outcomes of high-risk neuroblastoma in Southeast Asia: a single-institution experience and review of the literature
Authors: Lee Anselm Chi-Wai , Chui Chan Hon , Kwok Robert , Lee Kim Shang , Fong Chee Meng , Wong Wilfred Hing-Sang 
Published: April 2023

Introduction:
In Europe and North America, the majority of children with high-risk neuroblastoma survive the disease. Elsewhere, the treatment outcomes are poor.

Methods:
A retrospective review of children treated for high-risk neuroblastoma in a single institution in Singapore from 2007 to 2019 was carried out. Treatment consisted of intensive chemotherapy, surgery aimed at gross total resection of residual disease after chemotherapy, consolidation with high-dose therapy followed by autologous stem cell rescue, and radiotherapy to the primary and metastatic sites followed by maintenance treatment with either cis-retinoic acid or anti-disialoganglioside monoclonal antibody therapy. Survival data were examined on certain clinical and laboratory factors.

Results:
There were 57 children (32 male) treated for high-risk neuroblastoma. Their mean age was 3.9 (range 0.7–14.9) years. The median follow-up time was 5.5 (range 1.8–13.0) years for the surviving patients. There were 31 survivors, with 27 patients surviving in first remission, and the five-year overall survival and event-free survival rates were 52.5% and 47.4%, respectively. On log-rank testing, only the group of 17 patients who were exclusively treated at our centre had a survival advantage. Their five-year overall survival rate compared to patients whose initial chemotherapy was done elsewhere was 81.6% versus 41.1% (P = 0.011), and that of event-free survival was 69.7% versus 36.1% (P = 0.032). Published treatment results were obtained from four countries in Southeast Asia with five-year overall survival rates from 13.5% to 28.2%.

Conclusion:
Intensified medical and surgical treatment for high-risk neuroblastoma proved to be effective, with superior survival rates compared to previous data from Southeast Asia.
Style, Function, and Design Influence in Early Classical Western Greece
Authors: Pope Spencer 
Published: April 2023

Abstract
This paper discusses the development of monumental temple building in Sicily and Magna Graecia in the early Classical Period in terms of style and design in relation to cult and political structures. It is demonstrated that there was a coherent style that defined a moment of rapid construction in Western Greece in 480 B.C., and that the noteworthy building in Sicily eventually influenced mainland Greek architecture. This moment of intense construction is one result of the victory over the Carthaginians in the Battle at Himera, which ushered in an exuberant political environment driven by ambitious tyrants that revised the urban built environment and cult distribution in Sicily.
The Mouthpiece of the Aulos Revisited
Authors: Wysłucha Kamila , Hagel Stefan 
Published: April 2023

Abstract
The precise nature of the aulos mouthpiece, especially in the Classical period and before, has been disputed: above all, was it a single or a double reed? A definitive answer to this question has the greatest consequences for the nature of aulos music regarding not only timbre but more importantly control of dynamics, phrasing, and microtonal adjustments. From a survey of iconographical, literary and archaeological evidence, it is argued that the instruments of higher cultural esteem were universally equipped with double reeds. Single reeds were known as well, but are almost completely eclipsed in our sources.