bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of infection prevention and control strategy in nursing managements during surgical operations in COVID‐19 patients based on Delphi method
Authors: Wu Qi , Jiang Hui‐juan , Chen Han‐qian 
Published: February 2023

AbstractAimThe aim of this study was to establish an infection prevention and control strategy for nursing managements during surgical operations in coronavirus disease 2019 (COVID‐19) patients.DesignA Delphi method.MethodsBetween November 2021 and March 2022, we first formulated a preliminary infection prevention and control strategy based on the literature review and institutional experience. Then, we applied Delphi method and performed expert surveys to reach a final strategy for nursing managements during surgical operations in COVID‐19 patients.ResultsThe strategy included seven dimensions with 34 items. The positive coefficients of Delphi experts in both surveys were 100%, indicating a high coordination among experts. The degree of authority and expert coordination coefficient were 0.91 and 0.097–0.213. After the second expert survey, value assignments for importance of each dimension and item were 4.21–5.00 and 4.21–4.76 points, respectively. The coefficients of variation for dimension and item were 0.09–0.19 and 0.05–0.19, respectively.Patient or Public ContributionExcept the medical experts and research personnel, there was no other patient or public contribution involved in the study.
Quality of work‐life and coping strategies of nurse educators and clinicians in COVID‐19: A cross‐sectional study
Authors: Poku Collins Atta , Bayuo Jonathan , Mensah Eva , Bam Victoria 
Published: February 2023

AbstractThe study compared perceived differences in Quality of Work‐Life (QoWL) among nurse clinicians and educators and coping strategies used by nurses.DesignA cross‐sectional study.MethodsFrom August and November 2020, the study measured the QoWL and coping strategies of 360 nurses with two scales using a multi‐stage sampling technique. The data were analysed with descriptive, Pearson correlation and multivariate linear regression analyses.ResultsQuality of Work‐Life was generally low among nurses; nurse educators, however, had better QoWL than clinical nurses. Age, salary and nature of work predicted the QoWL of nurses. Work‐family segmentation, seeking assistance, open communication and recreational activities were employed by most nurses to cope with challenges. With the rate of workload and work‐related stress associated with COVID‐19, nurse leaders must advocate for evidence‐based coping strategies to deal with work and family life stress.
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis
Authors: Van der Vreken Arne , Oudaert Inge , Ates Gamze , Faict Sylvia , Vlummens Philip , Satilmis Hatice , Fan Rong , Maes Anke , Massie Ann , De Veirman Kim , De Bruyne Elke , Vanderkerken Karin , Menu Eline 
Published: February 2023

AbstractMultiple myeloma (MM) remains an incurable haematological malignancy despite substantial advances in therapy. Hypoxic bone marrow induces metabolic rewiring in MM cells contributing to survival and drug resistance. Therefore, targeting metabolic pathways may offer an alternative treatment option. In this study, we repurpose two FDA‐approved drugs, syrosingopine and metformin. Syrosingopine was used as a dual inhibitor of monocarboxylate transporter 1 and 4 (MCT1/4) and metformin as an inhibitor for oxidative phosphorylation (OXPHOS). Anti‐tumour effects were evaluated for single agents and in combination therapy. Survival and expression data for MCT1/MCT4 were obtained from the Total Therapy 2, Mulligan, and Multiple Myeloma Research Foundation cohorts. Cell death, viability, and proliferation were measured using Annexin V/7‐AAD, CellTiterGlo, and BrdU, respectively. Metabolic effects were assessed using Seahorse Glycolytic Rate assays and LactateGlo assays. Differential protein expression was determined using western blotting, and the SUnSET method was implemented to quantify protein synthesis. Finally, the syngeneic 5T33MMvv model was used for in vivo analysis. High‐level expression of MCT1 and MCT4 both correlated with a significantly lower overall survival of patients. Lactate production as well as MCT1/MCT4 expression were significantly upregulated in hypoxia, confirming the Warburg effect in MM. Dual inhibition of MCT1/4 with syrosingopine resulted in intracellular lactate accumulation and reduced cell viability and proliferation. However, only at higher doses (>10 μm) was syrosingopine able to induce cell death. By contrast, combination treatment of syrosingopine with metformin was highly cytotoxic for MM cell lines and primary patient samples and resulted in a suppression of both glycolysis and OXPHOS. Moreover, pathway analysis revealed an upregulation of the energy sensor p‐AMPKα and more downstream a reduction in protein synthesis. Finally, the combination treatment resulted in a significant reduction in tumour burden in vivo. This study proposes an alternative combination treatment for MM and provides insight into intracellular effects. © 2023 The Pathological Society of Great Britain and Ireland.
Introduction to interventional oncology: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper
Authors: Gill Anne E. , Hawkins C. Matthew 
Published: February 2023

AbstractInterventional radiology (IR) is a valuable resource when caring for pediatric solid tumor patients. As minimally invasive, image‐guided procedures become more relied upon to answer challenging diagnostic questions and provide alternative therapeutic options, IR is poised to become a contributing member of the multidisciplinary oncology team. Improved imaging techniques allow for better visualization during biopsy procedures, transarterial locoregional treatments have the potential to deliver targeted cytotoxic therapy while limiting systemic side effects, and percutaneous thermal ablation can be used to treat chemo‐resistant tumors of various solid organs. Additionally, interventional radiologists are able to perform routine, supportive procedures for oncology patients that include central venous access placement, lumbar punctures, and enteric feeding tube placements with high levels of technical success and excellent safety profiles.
Novel, solvent‐based method for the production of polymer sheets with a superhydrophobic surface
Authors: Vámos Csenge , Rácz Ilona , Bárány Tamás , Menyhárd Alfréd , Marosfői Botond Béla 
Published: February 2023

AbstractWe have introduced a novel solvent‐based method to roughen polymer surfaces and characterized treated polypropylene (PP). The method consists of three main steps: solvent treatment, drying, and peeling. We investigated the effects of process parameters such as time of immersion in the solvent, solvent temperature, and drying temperature on the surface morphology created. The structure formed on the surface is mainly influenced by solvent temperature and drying temperature. We also characterized the wetting behavior of the surfaces. The patterned surfaces exhibit superhydrophobic characteristics with a high water contact angle (CA) (>155 °) and low water contact hysteresis (<5°). Adding an effective nucleating agent to PP makes it possible to generate outstanding CAs (>160°) and tailor spherulite sizes. The method is simple and scalable, therefore this superhydrophobic material is easy to mass‐produce.
Respiratory physiology during NAVA ventilation in neonates born with a congenital diaphragmatic hernia: The “NAVA‐diaph” pilot study
Authors: Dreyfus Lélia , Butin Marine , Plaisant Frank , Claris Olivier , Baudin Florent 
Published: February 2023

AbstractBackgroundNeurally adjusted ventilatory assist (NAVA) is a ventilatory mode that delivers synchronized ventilation, proportional to the electrical activity of the diaphragm (EAdi). Although it has been proposed in infants with a congenital diaphragmatic hernia (CDH), the diaphragmatic defect and the surgical repair could alter the physiology of the diaphragm.AimTo evaluate, in a pilot study, the relationship between the respiratory drive (EAdi) and the respiratory effort in neonates with CDH during the postsurgical period under either NAVA ventilation or conventional ventilation (CV).MethodsThis prospective physiological study included eight neonates admitted to a neonatal intensive care unit with a diagnosis of CDH. EAdi, esophageal, gastric, and transdiaphragmatic pressure, as well as clinical parameters, were recorded during NAVA and CV (synchronized intermittent mandatory pressure ventilation) in the postsurgical period.ResultsEAdi was detectable and there was a correlation between the ΔEAdi (maximal − minimal values) and the transdiaphragmatic pressure (r = 0.26, 95% confidence interval [CI] [0.222; 0.299]). There was no significant difference in terms of clinical or physiological parameters during NAVA compared to CV, including work of breathing.ConclusionRespiratory drive and effort were correlated in infants with CDH and therefore NAVA is a suitable proportional mode in this population. EAdi can also be used to monitor the diaphragm for individualized support.
Understanding crop colonization of oilseed rape crops by the cabbage stem flea beetle (Psylliodes chrysocephala L. (Coleoptera: Chrysomelidae))
Authors: Tixeront Margot , Dupuy Fabienne , Cortesero Anne Marie , Hervé Maxime R. 
Published: February 2023

AbstractBACKGROUNDDevelopment of accurate pest monitoring systems is essential for the establishment of integrated pest management strategies. Information about the pest behavior during the colonization process, as well as the sex and reproductive status of the colonizing population often are lacking and hinder their development. The cabbage stem flea beetle (CSFB, Psylliodes chrysocephala) can cause the complete destruction of oilseed rape crops (OSR, Brassica napus). In the present study, the colonization process of OSR fields by the CSFB was studied.RESULTSMore individuals were caught on the outward facing side of the traps than the side of the trap facing towards the crop at the field border and catches were higher on the trapping units at the center of the field than at its border, suggesting that more beetles were entering than leaving the crop. Catches were higher on lower traps placed near to the crop than on those positioned further from the ground and also were higher during the day than late afternoon and night. The sex‐ratio of individuals caught was skewed towards males and sexual maturity was acquired for females during the experiment. Integration of sampling data with local meteorological data showed that the catches correlated mostly with air temperature and relative humidity.CONCLUSIONThis study provides new information about the dispersion of the CSFB in OSR fields during the colonization process, and highlights correlations between local meteorological factors and activity of the CSFB, and represent a new step towards implementing monitoring strategies against this pest. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
A critique of the use of modified and moving average‐based EWMA control charts
Authors: Haq Abdul , Woodall William H. 
Published: February 2023

AbstractWe show that the so‐called modified exponentially weighted moving average (EWMA) control chart is very closely related to a moving average‐based EWMA chart. These charts have ill‐advised weighting functions that assign more weight to some past data values than to the most recent data values. We show that these weighting functions adversely affect their run length properties and that one can obtain better overall performance with an ordinary EWMA chart.
Push and pull in the sustainable development of ecological landscape and ecological resources: A dual perceptions of tourists and service staff
Authors: Yi Kui , Zhu Jing , Zhang Qingyu , Li Fengcai , Li Xi 
Published: February 2023

AbstractThe protection of the ecological landscape and the development of ecological resources are vital in the development of the global green economy, Their win‐win coordinated development is influenced by factors such as nature, culture, and economy, and more attention should be placed on tourist perception and sustainable resource development. Previous studies have mainly focused on a single perspective and failed to comprehensively consider the coordinated relationship between ecological landscape and ecological resources. This research combined push‐and‐pull theory and applied empirical analysis to verify the structure of tourists' perceptions and the law of sustainable development of resources related to the development of ecological landscape in the new era. It extracted and analyzed 34 influencing factors and applied the analytic network process (ANP) to analyze each factor's weights, to propose an evaluation system for eco‐tourism sustainability development that can help the construction of ecological landscape in the future. The reconstruction and further development of eco‐tourism in the new era is reflected in the ideological and practical dimensions; from single‐perspective linear thinking to multi‐dimensional integrated governance; from conflict between resources conservation and development to collaboration; from isolated management to building a community with a shared future; and showing the transformation and innovation at multiple levels of individual, community, government and national governance.
A Versatile Theranostic Nanoplatform with Aggregation‐Induced Emission Properties: Fluorescence Monitoring, Cellular Organelle Targeting, and Image‐Guided Photodynamic Therapy
Authors: Ma Haijun , Li Ruoxin , Meng Haibing , Tian Mei , Zhang Xianhong , Liu Yanling , Li Le , Yuan Jinying , Wei Yen 
Published: February 2023

AbstractPhotosensitizers (PSs) play a key role in the photodynamic therapy (PDT) of tumors. However, commonly used PSs are prone to intrinsic fluorescence aggregation‐caused quenching and photobleaching; this drawback severely limits the clinical application of PDT, necessitating new phototheranostic agents. Herein, a multifunctional theranostic nanoplatform (named TTCBTA NP) is designed and constructed to achieve fluorescence monitoring, lysosome‐specific targeting, and image‐guided PDT. TTCBTA with a twisted conformation and D‐A structure is encapsulated in amphiphilic Pluronic F127 to form nanoparticles (NPs) in ultrapure water. The NPs exhibit biocompatibility, high stability, strong near‐infrared emission, and desirable reactive oxygen species (ROSs) production capacity. The TTCBTA NPs also show high‐efficiency photo‐damage, negligible dark toxicity, excellent fluorescent tracing, and high accumulation in lysosome for tumor cells. Furthermore, TTCBTA NPs are used to obtain fluorescence images with good resolution of MCF‐7 tumors in xenografted BALB/c nude mice. Crucially, TTCBTA NPs present a strong tumor ablation ability and image‐guided PDT effect by generating abundant ROSs upon laser irradiation. These results demonstrate that the TTCBTA NP theranostic nanoplatform may enable highly efficient near‐infrared fluorescence image‐guided PDT.
Recent Advances of Carbon Dots with Afterglow Emission
Authors: Shi Huixian , Wu Yang , Xu Jiahui , Shi Huifang , An Zhongfu 
Published: February 2023

AbstractCarbon dots (CDs) have gradually become a new generation of nano‐luminescent materials, which have received extensive attention due to excellent optical properties, wide source of raw materials, low toxicity, and good biocompatibility. In recent years, there are many reports on the luminescent phenomenon of CDs, and great progress has been achieved. However,there are rarely systematic summaries on CDs with persistent luminescence. Here, a summary of the recent progress on persistent luminescent CDs, including luminous mechanism, synthetic strategies, property regulation, and potential applications, is given. First, a brief introduction is given to the development of CDs luminescent materials. Then, the luminous mechanism of afterglow CDs from room temperature phosphorescence (RTP), delayed fluorescence (DF), and long persistent luminescence (LPL) is discussed. Next, the constructed methods of luminescent CDs materials are summarized from two aspects, including matrix‐free self‐protected and matrix‐protected CDs. Moreover, the regulation of afterglow properties from color, lifetime, and efficiency is presented. Afterwards, the potential applications of CDs, such as anti‐counterfeiting, information encryption, sensing, bio‐imaging, multicolor display, LED devices, etc., are reviewed. Finally, an outlook on the development of CDs materials and applications is proposed.
Ultra‐Stretchable Spiral Hybrid Conductive Fiber with 500%‐Strain Electric Stability and Deformation‐Independent Linear Temperature Response
Authors: Wu Jianpeng , Sang Min , Zhang Jingyi , Sun Yuxi , Wang Xinyi , Zhang Junshuo , Pang Haoming , Luo Tianzhi , Pan Shaoshan , Xuan Shouhu , Gong Xinglong 
Published: February 2023

AbstractStretchable configuration occupies priority in devising flexible conductors used in intelligent electronics and implantable sensors. While most conductive configurations cannot suppress electrical variations against extreme deformation and ignore inherent material characteristics. Herein, a spiral hybrid conductive fiber (SHCF) composed of aramid polymeric matrix and silver nanowires (AgNWs) coating is fabricated through shaping and dipping processes. The homochiral coiled configuration mimicked by plant tendrils not only enables its high elongation (958%), but also generates a superior deformation‐insensitive effect to existing stretchable conductors. The resistance of SHCF maintains remarkable stability against extreme strain (500%), impact damage, air exposure (90 days), and cyclic bending (150 000 times). Moreover, the thermal‐induced densification of AgNWs on SHCF achieves precise and linear temperature response toward a broad range (−20 to 100 °C). Its sensitivity further manifests high independence to tensile strain (0%–500%), allowing for flexible temperature monitoring of curved objects. Such unique strain‐tolerant electrical stability and thermosensation hold broad prospects for SHCF in lossless power transferring and expeditious thermal analysis.
Constructing Active BN Sites in Carbon Nanosheets for High‐Capacity and Fast Charging Toward Potassium Ion Storage
Authors: Yang Liuqian , Cao Zhen , Yin Jian , Wang Chunyan , Ouyang Dandan , Zhu Hui , Wang Yanan , Cavallo Luigi , Alshareef Husam N. , Yin Jiao 
Published: February 2023

AbstractNitrogen doping is an effective strategy to improve potassium ion storage of carbon electrodes via the creation of adsorption sites. However, various undesired defects are often uncontrollably generated during the doping process, limiting doping effect on capacity enhancement and deteriorating the electric conductivity. Herein, boron element is additionally introduced to construct 3D interconnected B, N co‐doped carbon nanosheets to remedy these adverse effects. This work demonstrates that boron incorporation preferentially converts pyrrolic N species into BN sites with lower adsorption energy barrier, further enhancing the capacity of B, N co‐doped carbon. Meanwhile, the electric conductivity is modulated via the conjugation effect between the electron‐rich N and electron‐deficient B, accelerating the charge‐transfer kinetics of potassium ions. The optimized samples deliver a high specific capacity, high rate capability, and long‐term cyclic stability (532.1 mAh g−1 at 0.05 A g−1, 162.6 mAh g−1 at 2 A g−1 over 8000 cycles). Furthermore, hybrid capacitors using the B, N co‐doped carbon anode deliver a high energy and power density with excellent cycle life. This study demonstrates a promising approach using BN sites for adsorptive capacity and electric conductivity enhancement in carbon materials for electrochemical energy storage applications.
Naringin against doxorubicin‐induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up‐regulation of SIRT1
Authors: Xi Yan , Chi Zhongchao , Tao Xufeng , Zhai Xiaohan , Zhao Zirui , Ren Jiaqi , Yang Shilei , Dong Deshi 
Published: February 2023

AbstractClinical application of doxorubicin is limited because of its potential side effects. The present study examined whether naringin had protective actions on doxorubicin‐induced liver injury. Male BALB/c mice and alpha mouse liver 12 (AML‐12) cells were used in this paper. The results showed that AML‐12 cells treated with naringin significantly reduced cell injury, reactive oxygen species release and apoptosis level; Moreover, naringin notably alleviated liver injury by decreasing aspartate transaminase, alanine transaminase and malondialdehyde, and increasing superoxide dismutase, glutathione and catalase levels. Mechanism researches indicated that naringin increased the expression levels of sirtuin 1 (SIRT1), and inhibited the downstream inflammatory, apoptotic and oxidative stress signaling pathways. Further validation was obtained by knocking down SIRT1 in vitro, which proved the effects of naringin on doxorubicin‐induced liver injury. Therefore, naringin is a valuable lead compound for preventing doxorubicin‐induced liver damage by reducing oxidative stress, inflammation, and apoptosis via up‐regulation of SIRT1.
Pumping stations for today's steel degassing requirements
Authors: Heitz Ingo , Boller Moritz 
Published: February 2023

SummaryThis article focuses on the vacuum equipment used in vacuum degassing (VD) and vacuum oxygen decarburization (VOD) processes. Despite harsh process conditions caused by outgassing and the process gases themselves, there are various pumping principles and designs of vacuum pumps that can be used. Through clever pump selection there is an opportunity to realize substantial energy and operating resource savings on the vacuum pumping side. Last but not least, a new pump series will be presented that further contributes to cost reduction through higher efficiency.
Vakuumdeponierte dünne Schichten polarisieren
Authors: Sattler René 
Published: February 2023

ZusammenfassungAußergewöhnliche Anwendungen erfordern außergewöhnliche Lösungen. Mit Fachwissen und den technischen Möglichkeiten von heute lassen sich im Bereich der Dünnfilmpolarisatoren auch komplexe Schichtdesigns umsetzen, mit denen sich Funktionalitäten und Anwendungsbereiche erschließen, die für diese Optiken bisher überhaupt nicht in Betracht gezogen wurden – zum Beispiel als „Leuchtkraftverstärker“ in Projektoren oder als „Effizienz‐Boost“ beim Erzeugen von frequenzverdoppelten Laserstrahlen.
3D‐Druck für Hochvakuumanwendungen
Authors: Wolf Christian , Prechtl Martin , Bauer René , Dinkel Michael , Beck Fabian , Franz Leopold , Neumeyer Viktor 
Published: February 2023

ZusammenfassungAnlässlich unseres Jubiläums präsentieren wir von den Lesern unserer Online‐Ausgabe besonders geschätzte Beiträge erneut im Druck. Hier:Die 3D‐Druck‐Technologie hat den Sprung von einer hobbymäßigen Privatanwendung in den industriellen Fertigungsbereich geschafft. Auf Grund wachsender Zuverlässigkeit der Drucker und zunehmender Material‐diversität, insbesondere im Metallbereich, sind in den kommenden Jahren Steigerungsraten im zweistelligen Prozentbereich möglich.Diese Arbeit beschäftigt sich mit der Fertigung von Bauteilen mittels 3D‐Drucks für einen Einsatz im Hochvakuum. Es werden unterschiedliche Komponenten realisiert und auf ihre Vakuumtauglichkeit untersucht.Wie in dieser Arbeit zudem gezeigt, können herkömmlich hergestellte Standardkomponenten mit gedruckten Teilen vakuumdicht verschweißt werden, was eine kostengünstige Fertigung komplexerer Komponenten wie z. B. einer Vakuumkammer ermöglicht. Darüber hinaus lassen sich funktionale Komponenten bereits im Herstellungsprozess verwirklichen. Die Integration eines Systems aus Strömungskanälen direkt in die Wandung einer Vakuumkammer ist nur ein Beispiel hierfür. Damit lässt sich dieser Rezipient beim Evakuieren ausheizen und im späteren Betrieb effektiv kühlen.