bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine Learning to Understand Genetic and Clinical Factors Associated With the Pulse Waveform Dicrotic Notch
Authors: Cunningham Jonathan W. , Di Achille Paolo , Morrill Valerie N. , Weng Lu-Chen , Choi Seung Hoan , Khurshid Shaan , Nauffal Victor , Pirruccello James P. , Solomon Scott D. , Batra Puneet , Ho Jennifer E. , Philippakis Anthony A. , Ellinor Patrick T. , Lubitz Steven A. 
Published: December 2022

Background:
Absence of a dicrotic notch on finger photoplethysmography is an easily ascertainable and inexpensive trait that has been associated with age and prevalent cardiovascular disease. However, the trait exists along a continuum, and little is known about its genetic underpinnings or prognostic value for incident cardiovascular disease.

Methods:
In 169 787 participants in the UK Biobank, we identified absent dicrotic notch on photoplethysmography and created a novel continuous trait reflecting notch smoothness using machine learning. Next, we determined the heritability, genetic basis, polygenic risk, and clinical relations for the binary absent notch trait and the newly derived continuous notch smoothness trait.

Results:

Heritability of the continuous notch smoothness trait was 7.5%, compared with 5.6% for the binary absent notch trait. A genome-wide association study of notch smoothness identified 15 significant loci, implicating genes including
NT5C2
(
P
=1.2×10
−26
),
IGFBP3
(
P
=4.8×10
−18
), and
PHACTR1
(
P
=1.4×10
−13
), compared with 6 loci for the binary absent notch trait. Notch smoothness stratified risk of incident myocardial infarction or coronary artery disease, stroke, heart failure, and aortic stenosis. A polygenic risk score for notch smoothness was associated with incident cardiovascular disease and all-cause death in UK Biobank participants without available photoplethysmography data.

Conclusions:
We found that a machine learning derived continuous trait reflecting dicrotic notch smoothness on photoplethysmography was heritable and associated with genes involved in vascular stiffness. Greater notch smoothness was associated with greater risk of incident cardiovascular disease. Raw digital phenotyping may identify individuals at risk for disease via specific genetic pathways.
Crossmodal Texture Perception Is Illumination-Dependent
Authors: Kangur Karina , Giesel Martin , Harris Julie M. , Hesse Constanze 
Published: December 2022

Abstract
Visually perceived roughness of 3D textures varies with illumination direction. Surfaces appear rougher when the illumination angle is lowered resulting in a lack of roughness constancy. Here we aimed to investigate whether the visual system also relies on illumination-dependent features when judging roughness in a crossmodal matching task or whether it can access illumination-invariant surface features that can also be evaluated by the tactile system. Participants () explored an abrasive paper of medium physical roughness either tactually, or visually under two different illumination conditions (top vs oblique angle). Subsequently, they had to judge if a comparison stimulus (varying in physical roughness) matched the previously explored standard. Matching was either performed using the same modality as during exploration (intramodal) or using a different modality (crossmodal). In the intramodal conditions, participants performed equally well independent of the modality or illumination employed. In the crossmodal conditions, participants selected rougher tactile matches after exploring the standard visually under oblique illumination than under top illumination. Conversely, after tactile exploration, they selected smoother visual matches under oblique than under top illumination. These findings confirm that visual roughness perception depends on illumination direction and show, for the first time, that this failure of roughness constancy also transfers to judgements made crossmodally.
Let’s Talk about the Animals – Taking the Outcomes of Animal Models of Human Emotion and Affective Behavior Back to Understanding Animal Minds and Emotions
Authors: Gaspar Augusta D. , Carvalho Constança 
Published: December 2022

Abstract
The socioemotional lives of animals have been brought to light over the years by studies seeking to address specific topics in animal emotion, cognition and behavior. Breakthrough information has been provided by field work with natural communities, and notable advances have stemmed from non-invasive research with captive animals and from laboratory work entailing varying degrees of invasiveness. But there is a source of information on animals that has not always been integrated in the knowledge on animals’ emotional lives: the outputs of studies where animals served as models of human emotional processes but that were seldom published as literature on animals. This article proposes an integrated view whereby the vast amount of information amassed by the brain and behavioral sciences over the course of the last 30 years on the affective experiences of animals, their triggers, biomarkers and behavioral correlates is fully integrated in an account of animal emotions. Topics where this knowledge can accommodate further integration from studies with animals models of the human mind are the parental care and different types of affective bonds; the experience of empathic reactions, the association between emotions, expressive behavior and affective bonds, and conscience. Fostering further connection between these neuroscience and behavioral studies might contribute to 1) widening the breath of measures used in assessing the well-being of animals, 2) widening criteria used by ethical committees considering studies with animals, and 3) to review some common practices that by those who have key roles in the management of wild or captive animals.
Quantifying the Predictability of ENSO Complexity Using a Statistically Accurate Multiscale Stochastic Model and Information Theory
Authors: Fang Xianghui , Chen Nan 
Published: December 2022

Abstract
An information theory–based framework is developed to assess the predictability and quantify the forecast uncertainty of ENSO complexity, which includes different types of ENSO events with diverse characteristics. With the assistance of a recently developed multiscale stochastic conceptual model that successfully captures both the large-scale dynamics and many crucial statistical properties of the observed ENSO complexity, it is shown that different ENSO events possess distinct predictability limits. Beyond the ensemble mean value, the spread of the ensemble members also contains valuable information about predictability. First, La Niña events are most predictable at long lead times, especially as a subsequent transition after eastern Pacific (EP) El Niño events or during multiyear La Niña phases. Second, EP El Niños tend to be more predictable than the central Pacific (CP) El Niño events up to one year ahead due to a more favorable signal-to-noise ratio, even though their onset remains hard to predict. Third, 4 out of 6 CP El Niño events seem to be predictable up to 24 months ahead, where such strong predictability is often converted to skillful forecast. Fourth, strengthening/weakening the Walker circulation intensity increases/decreases CP predictability at long leads. Fifth, accounting for intraseasonal wind events in the initial condition strongly contributes to EP predictability at lead times of less than one year. Finally, it is shown that a Gaussian approximation of the information gain computation is accurate, making the information theory approach tractable for studying the predictability of more sophisticated models.
Climate and Surface Mass Balance at Glaciar Perito Moreno, Southern Patagonia
Authors: Minowa Masahiro , Skvarca Pedro , Fujita Koji 
Published: December 2022

Abstract
The mass budget of southern Patagonian glaciers is characterized by an extreme amount of surface ablation. To understand the processes controlling surface mass balance, we analyzed in situ data including meteorological variables and ablation stakes for the 25 years between 1996 and 2020 near the terminus of Glaciar Perito Moreno in southern Patagonia in South America. The mean annual temperature has increased over the study period at a rate of 0.2°C decade−1. An energy-balance model was applied to calculate a point surface mass balance, based on meteorological records. The average point surface mass balance is estimated to be −16.3 m water equivalent (w.e.) yr−1 between 1996 and 2020, decreasing at a rate in the range from −0.4 to −0.9 m w.e. yr−1 decade−1. The greatest contribution to the surface energy balance was due to the sensible heat flux, and its variation drove the surface mass balance variation. The meteorological and surface mass balance records were compared with the Southern Annular Mode and El Niño–Southern Oscillation, which change the atmospheric circulation over southern Patagonia and influence surface mass balance near the terminus of the glacier. Our long-term dataset investigates the detailed meteorological conditions and surface mass balance and their connection with the large-scale climate variability over the last 25 years, reported for the first time in Patagonia.
Asymmetric Boreal Summer Intraseasonal Oscillation Events over the Western North Pacific and Their Impacts on East Asian Precipitation
Authors: Li Wen , Yang Xiu-Qun , Fang Jiabei , Tao Lingfeng , Sun Xuguang 
Published: December 2022

Abstract
The boreal summer intraseasonal oscillation (BSISO) is the most prominent tropical subseasonal signature. Due to the restriction of methodology used to extract BSISO, most of the previous studies ignored its asymmetry. This study reexamines the BSISO events over the western North Pacific (WNP) for 1985–2010 with a hierarchical cluster analysis. Two categories of BSISO events are classified, the long-period (20–60 day) and short-period (10–20 day) events. The long-period BSISO events manifest as a northward-propagating mode with a significant phase asymmetry characterized by a fast development, but a slow decay of the intraseasonal convection. The phase asymmetry is found to be determined by the BSISO-induced amplitude-asymmetric sea surface temperature (SST) anomalies, in which the suppressed convection-induced positive SST anomalies are stronger than the active convection-induced negative ones. Such amplitude-asymmetric SST anomalies result from the nonlinear relationship between convection and surface downward shortwave radiation flux anomalies caused by the cloud transmission effect. The stronger positive SST anomalies–induced turbulence flux anomalies act as a negative feedback onto the atmosphere, making the transition from the convection suppressed phase to the active phase earlier and faster. The fast-developing convection tends to cause a fast northeastward retreat of the preceding enhanced western North Pacific subtropical high. Accordingly, the middle and lower reaches of Yangtze River valley experience a rapid reversal from the increased precipitation to the decreased. The asymmetric BSISO events over WNP and their impacts revealed in this study would provide a new potential for subseasonal-to-seasonal forecast of the East Asian summer monsoon precipitation.
Relationship between ganglion cell complex thickness and vision in age-related macular degeneration treated with aflibercept
Authors: Buyukavsar Cihan , Sonmez Murat , Sagdic Sercan Koray , Unal Melih Hamdi 
Published: December 2022

Purpose This study aimed to analyze the correlation between ganglion cell complex thickness (GCCT) and vision compared with the choroidal thickness (CT) and central retinal thickness (CRT) in relation to the outcomes of intravitreal aflibercept treatment for choroidal neovascular membranes secondary to age-related macular degeneration (AMD). Methods This was a prospective, observational study. Forty-three eyes of 38 patients with wet AMD received a monthly loading dose of 2 mg aflibercept by intravitreal injection (IVI) during the first 3 months and were then followed at regular monthly intervals for an average of 10 months by a pro re nata regimen. All patients were examined using spectral domain-optic coherence tomography (OCT) and enhanced depth imaging OCT. According to their response to IVI treatment in the third month, patients were divided into 2 groups, both functionally and anatomically. Results Three-month GCCT and optic disc retinal nerve fiber layer thickness (ODRNFLT) had the most correlation with the 10-month vision (p  =  0.002, p  =  0.02, respectively). While baseline GCCT was most correlated with the functional response, baseline CRT was most correlated with the anatomical response (p  =  0.01, p  =  0.004, respectively). Conclusions The results suggest that a reduction in 3-month GCCT indicates a good long-term vision outcome, while a reduction in 3-month ODRNFLT shows a poor long-term vision outcome. The literature suggests that this study is the first to demonstrate that baseline GCCT is more strongly correlated with the functional response than it is with CT and CRT. Hence, GCCT has a prognostic value for vision impairment.
Is the socioeconomic inequality in stroke prognosis changing over time and does quality of care play a role?
Authors: Hyldgård Vibe Bolvig , Søgaard Rikke , Valentin Jan Brink , Lange Theis , Damgaard Dorte , Johnsen Søren Paaske 
Published: December 2022

Introduction: In a publicly financed healthcare system we aimed to study the development in socioeconomic disparity in ischemic stroke outcomes over time. In addition, we study whether the healthcare system affects these outcomes through the quality of early stroke care when adjustments are made for various patient characteristics incl. comorbidity and stroke severity. Patients and methods: Using nationwide, detailed individual-level register-data we analysed how income-related and education-related inequality in 30-day mortality and 30-day readmission risk developed between 2003 and 2018. In addition, focusing on income-related inequality, we applied mediation analyses to estimate the mediating role of quality of acute stroke care on 30-day mortality and 30-day readmission. Results: A total of 97,779 individual ischemic stroke patients were registered in Denmark with a first ever stroke in the study period. Three-point-seven percent died within 30 days of their index-admission and 11.5% were readmitted within 30 days of discharge. The income-related inequality in mortality remained virtually unchanged over time from an RR of 0.53 (95% CI: 0.38; 0.74) in 2003–06 to RR 0.69 (95% CI: 0.53; 0.89)) in 2015–18 when high income was compared to low income (Family income-time interaction: RR 1.00 (95% CI: 0.98–1.03)). A similar but less uniform trend was found for the education-related inequality in mortality (Education-time interaction: RR 1.00 (95% CI: 0.97–1.04)). The income-related disparity in 30-day readmission was smaller than in 30-day mortality and it diminished over time from 0.70 (95% CI: 0.58; 0.83) to 0.97 (95% CI: 0.87; 1.10). The mediation analysis showed no systematic mediating effect of quality of care on neither mortality nor readmission. However, it cannot be ruled out that residual confounding may have washed out some mediating effects. Discussion and Conclusion: The socioeconomic inequality in stroke mortality and re-admission risk has yet to be eliminated. Additional studies from different settings are warranted in order to clarify the impact of socioeconomic inequality of quality of acute stroke care.
Association of cholesterol levels with hemorrhagic transformation and cerebral edema after reperfusion therapies
Authors: Escudero-Martínez Irene , Thorén Magnus , Matusevicius Marius , Cooray Charith , Zini Andrea , Roffe Christine , Toni Danilo , Tsivgoulis Georgios , Ringleb Peter , Wahlgren Nils , Ahmed Niaz 
Published: December 2022

Background: The association between cholesterol levels and cerebral edema (CED) or hemorrhagic transformation (HT) as an expressions of blood-brain barrier (BBB) dysfunction after ischemic stroke is not well established. The aim of this study is to determine the association of total cholesterol (TC) levels with the incidence of HT and CED after reperfusion therapies. Methods: We analyzed SITS Thrombolysis and Thrombectomy Registry data from January 2011 to December 2017. We identified patients with data on TC levels at baseline. TC values were categorized in three groups (reference group ⩾200 mg/dl). The two primary outcomes were any parenchymal hemorrhage (PH) and moderate to severe CED on follow up imaging. Secondary outcomes included death and functional independence (mRS 0–2) at 3 months. Multivariable logistic regression analysis adjusted for baseline factors including statin pretreatment was used to assess the association between TC levels and outcomes. Results: Of 35,314 patients with available information on TC levels at baseline, 3372 (9.5%) presented with TC levels ⩽130 mg/dl, 8203 (23.2%) with TC 130–200 mg/dl and 23,739 (67.3%) with TC ⩾ 200 mg/dl. In the adjusted analyses, TC level as continuous variable was inversely associated with moderate to severe CED (OR 0.99, 95% CI 0.99–1.00, p = 0.025) and as categorical variable lower TC levels were associated with a higher risk of moderate to severe CED (aOR 1.24, 95% CI 1.10–1.40, p = 0.003). TC levels were not associated with any PH, functional independence, and mortality at 3 months. Conclusions: Our findings indicate an independent association between low levels of TC and higher odds of moderate/severe CED. Further studies are needed to confirm these findings.
Rift-related paleogeography of the European margin in the Eastern Alps (Central Tauern Window)
Authors: Groß Philip , Pleuger Jan , Handy Mark R. 
Published: December 2022

AbstractContinent-derived tectonic units in the Tauern Window of the Alps exhibit stratigraphic and structural traces of extension of continental margins eventually leading to the opening of the Alpine Tethys. In this study, we reassess lithostratigraphic data from the central part of the Tauern Window to reconstruct the post-Variscan evolution of this area, particularly the rift-related geometry of the European continental margin. The lithostratigraphy of the Alpine nappes reflects systematic variations of the structure of the European margin. The lowest tectonic units (Venediger nappe system, Eclogite Zone and Trögereck Nappe) are characterized by a thick succession of arkose-rich Bündnerschiefer-type sediments of probably Early Cretaceous age that we interpret as syn-rift sequence and which stratigraphically overlies thinned continental basement and thin pre-rift sediments. In contrast, the highest tectonic unit derived from Europe (Rote Wand Nappe) preserves a thick pre-rift sedimentary sequence overlying thinned continental basement, as well as a thick syn- to post-rift succession characterized by turbiditic Bündnerschiefer-type sediments of probable Cretaceous age. These observations point towards a highly segmented structure of the European rifted margin. We propose that this involved the formation of an outer margin high, partly preserved in the Rote Wand Nappe, that was separated from the main part of the European margin by a rift basin overlying strongly-thinned continental crust. The along-strike discontinuity of the Rote Wand Nappe is proposed to reflect the lateral variation in thickness of the outer margin high that resulted from margin-parallel segmentation of the European continental crust during highly oblique rifting antecedent to the opening of Alpine Tethys.
PLK1 protects intestinal barrier function during sepsis by targeting mitochondrial dynamics through TANK-NF-κB signalling
Authors: Cao Ying-Ya , Zhang Yuan , Gerile Wuyun , Guo Yan , Wu Li-Na , Wu Li-Li , Song Kai , Lu Wei-Hua , Yu Jian-Bo 
Published: December 2022

AbstractBackgroundIntestinal barrier integrity in the pathogenesis of sepsis is critical. Despite an abundance of evidence, the molecular mechanism of the intestinal barrier in sepsis pathology remains unclear. Here, we report a protective role of polo-like kinase 1 (PLK1) in intestinal barrier integrity during sepsis.MethodsMice with PLK1 overexpression (CAG-PLK1 mice) or PLK1 inhibition (BI2536-treated mice) underwent caecal ligation and puncture (CLP) to establish a sepsis model. The intestinal barrier function, apoptosis in the intestinal epithelium, mitochondrial function and NF-κB signalling activity were evaluated. To suppress the activation of NF-κB signalling, the NF-κB inhibitor PDTC, was administered. The Caco-2 cell line was chosen to establish an intestinal epithelial injury model in vitro.ResultsSepsis destroyed intestinal barrier function, induced excessive apoptosis in the intestinal epithelium, and disrupted the balance of mitochondrial dynamics in wild-type mice. PLK1 overexpression alleviated sepsis-induced damage to the intestinal epithelium by inhibiting the activation of NF-κB signalling. PLK1 colocalized and interacted with TANK in Caco-2 cells. Transfecting Caco-2 cells with TANK-SiRNA suppressed NF-κB signalling and ameliorated mitochondrial dysfunction, apoptosis and the high permeability of cells induced by lipopolysaccharide (LPS). Furthermore, TANK overexpression impaired the protective effect of PLK1 on LPS-induced injuries in Caco-2 cells.ConclusionOur findings reveal that the PLK1/TANK/NF-κB axis plays a crucial role in sepsis-induced intestinal barrier dysfunction by regulating mitochondrial dynamics and apoptosis in the intestinal epithelium and might be a potential therapeutic target in the clinic.
The potential of the EU Water Framework Directive for reducing emissions of pollutants is limited: a case study on river basin specific pollutants in Swedish environmental permitting processes
Authors: Undeman Emma , Josefsson Henrik , Ågerstrand Marlene , Sobek Anna , Nilsson Annika 
Published: December 2022

AbstractRiver basin specific pollutants (RBSPs) are supposedly a key tool to fulfil the EU’s Water Framework Directive (WFD) goal of good ecological status in all European waterbodies. The RBSPs provide a tool to manage chemical pollution identified as a national priority. An important question is if the costly management related to RBSPs leads to reduced emissions, an issue we investigated here using Sweden as a case. Swedish measures implemented under the WFD mainly rely on environmental permitting and supervision. We, therefore, specifically assessed how RBSPs have influenced permit proceedings in the Land and Environment Court of Appeal, where precedents for judgements in lower courts and authorities is established, during the 2010s. Despite permit-review being an important measure highlighted in the WFD and in Swedish programs of measures, all cases appealed to higher court were initiated by the operators/permit holders. The permissibility of environmentally hazardous activities was not impacted by RBSPs in any instance. Permit conditions addressing RBSPs were discussed in ⁓1% of all environmental cases, mainly resulting in conditions demanding further inquiries regarding emissions and concentrations of a limited number of RBSPs (i.e., metals and nitrogen in the forms of nitrate and ammonia). Open-ended conditions and delegation allowing for updating permit conditions if additional RBSPs are identified were suggested but rejected by court as these conflict with fundamental principles of precision and predictability of permit conditions stated in Swedish and European law. We conclude that RBSPs as management tool has little impact on emissions from activities requiring environmental permits and thereby water quality.