bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRATEGI MANAJEMEN SOSIALISASI PENYELENGGARAAN HAJI DAN UMRAH PT FAJRI TOUR TRAVEL TANGERANG
Authors: Rafiudin Ahmad , Aini Silvia Qurrotul 
Published: May 2023

The problems studied in this thesis are: How is the Umrah Jamaat Socialization Strategy carried out by Travel Indonesia PT. The purpose of this research is to find out the form of strategy in socializing with Umrah pilgrims at PT Fajri Tour Travel Tangerang. facts and data regarding the form of the Umrah Jama'at Socialization Strategy at PT Fajri Tour Travel Tangerang, then the data is described, analyzed and discussed to answer these problems. From the results of this study it was found that the strategy used by PT. Fajri Tour Travel Tangerang is an Intensive Strategy, which includes product development and increased product sales. This form of development is adapted to situations and conditions with a dynamic form, one of its characteristics is that marketing implementers can be creative according to the shape of the market they are facing. So with this dynamic form of development, it is also hoped that the increase in product sales has the opportunity to increase consumer acquisition from time to time. While the socialization process is carried out in collaboration with institutional parties, such as the taklim assembly, Islamic holidays and other events related to program socialization, and also always carries out socialization by providing good services, such as office services and when doing activities. socialization in agencies or institutions.
Keywoard: Management, Travel, Socialization
Diurnal variation in methane emission from a rice paddy due to ebullition
Authors: Kajiura Masako , Tokida Takeshi 
Published: May 2023

Abstract
The diurnal variation in methane (CH4) emission commonly observed in rice paddies has been linked to changes in air and soil temperatures. The temperature dependence is not simple, however, and the mechanisms underlying it in relation to the diurnal variation are still poorly understood. Here, we investigated the diurnal variation of CH4 flux and its relationship with air temperature in a Japanese paddy by dividing the total flux into two major pathways, plant-mediated and bubbling emission. The diurnal variation of total flux was minimal at the early parts of reproductive growth (panicle formation and booting stages), when plant-mediated emission was dominant. At a later stage (heading period), ebullition accounted for 43–70% of the total emission, and CH4 emission via both pathways varied diurnally; however, the diurnal range was much greater for bubbling emission (ratio of max. to min. = 3.5) than for plant-mediated emission (ratio of max. to min. = 1.4). The Bubbling emission depended on the temperature, but the emission was greater during the flux-increasing phase in the morning than the flux-decreasing phase in the afternoon even at the same temperature, forming a hysteresis in the flux versus temperature relationship. These results indicate that abiotic processes, such as a change in the solubility of gases and the temperature dependence of the gas-phase volume (Charles’s law), may play a central role in shaping the diurnal pattern of the CH4 ebullition.
MIR210HG may promote the progression of preeclampsia through CDHR5
Authors: Sun Ningxia , Zhang Lu , Xu Jine , Han Mengmeng , Chen Aiping , Liu Shiguo 
Published: May 2023

Abstract
Introduction:Because early diagnosis and timely detection of preeclampsia (PE) remains challenge. This study aims to explore the differential expression and pathogenic mechanism of the lncRNA MIR210HG in peripheral blood, which will lay the basis for its use as a biomarker of PE.
Methods: Total RNA was extracted from the peripheral blood of 88 women with preeclamptic pregnancies and 81 women with normal pregnancies. The MIR210HG expression levels were determined by RT-PCR and western blot. SiRNA and MIR210HG overexpression plasmids were constructed and transfected into human trophoblast and vascular endothelial cells.
Results: The lncRNA MIR210HG was significantly upregulated in the peripheral blood of patients with PE compared to the control group. Additionally, the expression level of MIR210HG in patients with early-onset PE was significantly higher than that of the control and late-onset PE groups. CDHR5, identified by bioinformatics predictions after RT-PCR confirmation, was upregulated in placental tissue compared to the control group. Furthermore, cytology experiments confirmed that knockdown of MIR210HG also decreased CDHR5 in human trophoblast and vascular endothelial cells. After knockdown of CDHR5, expression of MIR210HG was also reduced.
Discussion: The lncRNA MIR210HG is highly expressed in the peripheral blood of PE, indicating MIR210HG may become a potential biomarker for the diagnosis and prediction of PE. In addition, MIR210HG may interact with CDHR5 to jointly promote the progression of PE. However, further experiments are needed to confirm the pathogenic mechanism.
An operational matrix method based on scalingfunction of Daubechies wavelet to solve stochastic differential equations
Authors: Shariati Nasim Madah , Yaghouti Mohammadreza , Alipanah Amjad 
Published: May 2023

Abstract
In our joint work, by introducing Quasi Block-Pulse (QBP) functions, we provide integration and stochastic integration operational matrices based on scaling function of Daubechies wavelet to solve linear and nonlinea rstochastic differential equations. Due to interesting properties of the Daubechies wavelet such as orthogonality, compactly support and vanishing moments, these operational matrices have good properties. The convergenc eof the proposed method is presented and in order to verify the accuracy of the proposed method some numerical examples are provided.
Female sexual response to audiovisual stimuli in 2D/3D modality and first/third person perspective stance
Authors: Marečková Alena , Hůla Martin , Klapilová Kateřina , Novák Ondřej 
Published: May 2023

Abstract
The study investigates the effect of sexually explicit video stimuli displayed in a different modality (3D vs. 2D) and perspective (first vs. third person) on female sexual arousal, both subjective and genital, valence ratings, and sexual and general presence. We exposed 47 heterosexual female participants to four stimuli, two displayed on a flat screen and two using a VR headset. We used almost identical videos in both modalities and perspectives, thus eliminating any confounding variables caused by using different videos. We measured genital arousal via vaginal photoplethysmography (VPG) and subjective responses using questionnaires. We did not find any differences in modality or perspective in genital arousal. 2D videos were considered more subjectively arousing than the 3D videos (d = 0.33, p = 0.02). 2D videos and third-person perspective videos elicited stronger feelings of sexual (2D/3D: d = 0.86, p < 0.001; first/third person: d = 0.50, p < 0.001) and general presence (2D/3D: d = 1.09, p < 0.001; first/third person: d = 0.75, p < 0.001 ) than 3D videos and first-person perspective videos. Our findings are in discord with the previous studies. We discuss the possible causes of the observed differences.
Analysis of the Most Probable Exit Path in the synthetic gene network with genetic toggle
Authors: Guo Zhuqin , Xu Wei , Zhang Wenting 
Published: May 2023

Abstract
In the process of the development of biotechnology, the research on the manipulation and regulation of biochemical molecules such as genes and proteins has become a hot direction. In particular, the synthetic gene network with genetic toggle has attracted the attention of many scholars due to its great creative space and strong operability. However, the current research on synthetic gene network with genetic toggle mainly focuses on the influence of noise on the stability of the system and stochastic resonance. Little research has been done on exploring the switching process of the system with genetic toggle under noise excitation. In this paper, the most probable exit path(MPEP) is proposed to understand the switching of genetic toggle in the system. Firstly, we studied the MPEP of protein concentration switching in a bistable synthetic gene network with genetic toggle in E.coli organism when noise intensity is very small. Large deviation theory is used to explore the MPEP of protein concentration switching from a new perspective. Secondly, OM action functional is introduced to get the MPEP of the system under Gaussian white noise excitation. It is revealed that two independent noises have opposite effects on protein concentration switching. Finally, the MPEP is shown by energy landscape, and it is found that the reduction of noise intensity is not conducive to protein concentration switching.
EphrinA5 regulates cell motility by modulating lncRNA/DNA triplex-dependent targeting of DNMT1 to the Ncam1 promoter
Authors: Yildiz Can Bora , Kundu Tathagata Tathagata , Gehrmann Julia , Koesling Jannis , Ravaei Amin , Jakovcevski Mira , Pensold Daniel , Zimmerman Olav , Rossetti Giulia , Costa Ivan G. , Zimmer-Bensch Geraldine 
Published: May 2023

Abstract
Background:
Cell-cell communication is mediated by membrane receptors and their cognate ligands, such as the Eph/ephrin system, and dictates physiological processes, including cell proliferation and migration. However, whether and how Eph/ephrin signaling culminates in transcriptional regulation is largely unknown. Epigenetic mechanisms are key for integrating external “signals”, e.g., from neighboring cells, into the transcriptome. We have previously reported that ephrinA5 stimulation of immortalized cerebellar granule (CB) cells elicits transcriptional changes of lncRNAs and protein-coding genes. LncRNAs represent important adaptors for epigenetic writers through which they regulate gene expression. Hence, we here aimed to investigate, whether ephrinA5 can act on gene transcription through modulating lncRNA-mediated targeting of the DNA methyltransferase 1 (DNMT1) to gene promoters, thereby regulating cell motility.
Results:
We analyzed the interaction of lncRNA with protein-coding genes by the combined power of in silico modeling of RNA/DNA interactions and respective wet lab approaches. We found that Snhg15, a cancer-related lncRNA, forms a triplex structure with the Ncam1 promoter and interacts with DNMT1. EphrinA5 stimulation leads to reduced Snhg15 expression, diminished Snhg15/DNMT1 interaction and decreased DNMT1 association with the Ncam1 promoter. These findings can explain the attenuated Ncam1 promoter methylation and elevated Ncam1 expression induced by ephrinA5 stimulation that in turn elicits decreased cell motility of CB cells.
Conclusion:
Based on our findings, we propose that ephrinA5 influences gene transcription via lncRNA-targeted DNA methylation underlying the regulation of cellular motility. Such mechanism could be relevant in the context of cancerogenic processes, known to involve Eph/ephrin signaling and epigenetic remodelling.
The Effectiveness of a Medical Cocktail Therapy for Non-healing Refractory Ischemic Diabetic Foot Ulcers- Case Reports
Authors: Sureshkumar Pichakacheri , Kumar Sidharth S 
Published: May 2023

Abstract
INTRODUCTION:
Diabetic foot ulcers (DFU) are a serious complication of diabetes mellitus that can have significant medical and socioeconomic impact as well as increase in mortality rates. Healing of ischemic or neuro ischemic foot ulcers is most challenging as conventional therapies often fail to achieve adequate vascularity. Ulcers of the heel area can be very severe and strenuous to treat and can eventually end up in the amputation of the limb due to poor vascularity. So optimization of therapies to improve vascularity should be a major objective in successfully treating such cases.
CASE PRESENTATION:
Here we report two cases of chronic non-healing ischemic ulcers of the heel area of the foot. Patients approached us after the conventional medical treatments had failed to achieve healing. We treated them with a cocktail (Diabcare protocol) that we formulated using existing medications along with appropriate wound care and antibiotics. Diabcare protocol comprises plaque regression agents (statins), antiplatelet drugs (Aspirin), novel oral anticoagulant (Rivaroxaban) and vasoactive agents [PDE3 inhibitor (Cilostazol) and PDE5 inhibitor (Tadalafil)]. On Serial measurements, ulcers showed progressive healing and wound contraction. Vascularity improved significantly and fresh granulation appeared within days to weeks of initiation of therapy. Ulcers healed completely, with spontaneous epithelialization in the first case and after SSG in the second case, within a mean period of three months.
CONCLUSION
The ‘Diabcare protocol’ is found to be effective in healing difficult-to-heal ischemic foot ulcers where conventional treatment fails.
Causes of accelerated High-Tide Flooding in the U.S. since 1950
Authors: Sun Qiang , Dangendorf Sönke , Wahl Thomas , Thompson Philip 
Published: May 2023

Abstract
The U.S. coastlines have experienced rapid increases in occurrences of High Tide Flooding (HTF) during recent decades. While it is generally accepted that relative mean sea level (RMSL) rise is the dominant cause for this, an attribution to individual components is still lacking. Here we use local sea-level budgets to attribute past changes in HTF days to RMSL and its individual contributions. We find that while RMSL rise generally explains >90% of long-term increases in HTF days, their spatial patterns also depend on the flooding threshold location and local water level characteristics. Vertical land motion dominates long-term increases in HTF particularly in the northeast, while sterodynamic sea level (SDSL) is most important elsewhere and on shorter temporal scales. We show that the recent SDSL acceleration in the Gulf of Mexico has led to an increase in HTF of more than 220%, a number that is unpreceded both in time and space.
MSFC: A New Feature Construction Method for Accurate Diagnosis of Mass Spectrometry Data
Authors: feng xin , dong zheyuan , Li Yingrui , Cheng Qian , Xin Yongxian , Xin Ruihao 
Published: May 2023

Abstract
Background
Mass spectrometry technology can realize dynamic detection of many complex matrix samples in a simple, rapid, compassionate, precise, and high-throughput manner and has become an indispensable tool in accurate diagnosis. The mass spectrometry data analysis is mainly to analyze all metabolites in the organism quantitatively and to find the relative relationship between metabolites and physiological and pathological changes.
Methods
A feature construction of mass spectrometry data (MSFS) method is proposed to construct the features of the original mass spectrometry data, so as to reduce the noise in the mass spectrometry data, reduce the redundancy of the original data and improve the information content of the data. Chi-square test is used to select the optimal non-redundant feature subset from high-dimensional features. And the optimal feature subset is visually analyzed and corresponds to the original mass spectrum interval. Training in 10 kinds of supervised learning models, and evaluating the classification effect of the models through various evaluation indexes.
Results
Taking two public mass spectrometry datasets as examples, the feasibility of the method proposed in this paper is verified. In the coronary heart disease dataset, during the identification process of mixed batch samples, the classification accuracy on the test set reached 1.000; During the recognition process, the classification accuracy on the test set advanced to 0.979. On the colorectal liver metastases data set, the classification accuracy on the test set reached 1.000.
Conclusion
This paper attempts to use a new raw mass spectrometry data preprocessing method to realize the alignment operation of the raw mass spectrometry data, which significantly improves the classification accuracy and provides another new idea for mass spectrometry data analysis. Compared with MetaboAnalyst software and existing experimental results, the method proposed in this paper has obtained better classification results.
Association of the previous experience of maternal migration absence with non-suicidal self-injury (NSSI) in their children: A cross-sectional study in Anhui, China
Authors: Akezhuoli Hailati , Guo Shi , Zhao Honghui , Xu Jiayao , Xie Qianwen , Zhou Xudong , Lu Jingjing , Li Lu 
Published: May 2023

Abstract

Background
Non-suicidal self-injury (NSSI) emerged as an escalating health concern in youths worldwide, particularly in the vulnerable. In China, a burgeoning internal migration in human history has been tearing families apart, generating a surging number of left-behind children (LBC) with a lack of parental supervision. Despite the empirical acknowledgment of parental migration as a risk predictor of the NSSI among LBC, there remains a lack of understanding of the specific role of the maternal migration experience.
Objective
This study sought to determine the association of maternal migration experience and its characteristics in terms of age at initiation and length with 12-month NSSI among children. Participants & setting: Data were collected by a self-administrated questionnaire survey conducted among a school-based sample of students in the Anhui province, China.
Methods
A total of 2476 participants were analyzed, and the Chi-squared tests and binary logistic regression analysis were employed.
Results
Compared with children whose father is currently migrating and the mother never migrated for work (FM-MN), children whose father never migrated but the mother previously migrated for work (FN-MP, OR = 2.21, 95% CI [1.27–3.84], p < 0.01) and children whose father is currently migrating and the mother previously migrated for work (FM-MP, OR = 1.46, 95% CI [1.00-2.13], p < 0.05) evidenced greater odds of the prevalence of 12-month NSSI. And also, a significantly higher risk for 12-month NSSI was found among FN-MP and FM-MP compared with children whose parents lived in the household and neither had ever migrated for work (FN-MN). For those children with maternal migration experience, while controlling for the paternal migration characteristics, there was no difference between before and after school age at initiation of migration in the risk of NSSI, nor were there any differences across 1–3, 4–6, and more than 6 years of maternal migration length.
Conclusions
Findings suggested the potential long-term effect of the experience of maternal migration on children and provided implications for the early identification and prevention of children at risk for NSSI, particularly within the maternal migrant family context.
Impact of preoperative occult renal dysfunction on early and late prognosis in elderly patients with coronary artery bypass in China
Authors: Liu Zhonghe , Zhang Chong , Zhou Le , Sun Yangyang , Pan Yilin , Han Lixiang , Jin Lei , Li Zhi , Zhang Yangyang 
Published: May 2023

Abstract
Background
Renal dysfunction is related to the poor outcomes of cardiac surgery. Preoperative occult renal dysfunction (PORD) is defined as patients with normal serum creatinine (Scr) but the glomerular filtration rate (GFR) less than 60 ml/min/1.73m2. However, there is no report on prognosis of elderly PORD patients undergoing coronary artery bypass grafting (CABG). This problem deserves further exploration.
Methods
Totally 1103 patients undergoing CABG with normal Scr and age ≥ 70 years old were enrolled. The estimated GFR (eGFR) of each patient was monitored using the Berlin initiative study formula. The patients were divided by eGFR into PORD group and control group. Propensity score matching was used to adjust preoperative characteristics. Univariate and multivariate analyses were performed to identify risk factors for postoperative acute kidney injury (AKI) and postoperative mortality. The Kaplan-Meier method was applied to estimate survival rates. A multivariate cox regression model was used to analyze the impacts of factors on long-term survival.
Results
Elderly patients with normal Scr had high PORD proportion (27.65%). The PORD group had significantly higher preoperative Cr (99.20 ± 12.74 vs. 71.57 ± 11.96), postoperative AKI rates (39.13% vs. 17.75%) and postoperative mortality (5.80% vs. 1.81%) compared with control group. PORD was a significant risk factor for postoperative mortality (OR = 11.648) and postoperative AKI (OR = 2.731). PORD was also a significant risk factor for long-term death after CABG (HR = 1.724).
Conclusions
PORD is a risk factor for postoperative AKI and short- and long-term death in elderly patients undergoing CABG. eGFR shall be used to assess preoperative renal function.
Effects of prefrontal tDCS on working memory performance in chronic alcohol and tobacco use
Authors: Göttgens Franziska , Habel¹ Ute , Wallheinke Paul , Blendy Julie A. , Weidler¹ Carmen 
Published: May 2023

Abstract

Deficits in working memory (WM) are observable in a wide range of those psychiatric disorders associated with decreased activation of the prefrontal cortex. Given that WM is a crucial process supporting various cognitive functions, deficits interfere with daily life tasks and psychiatric treatment. The present study examines the influence of prefrontal brain stimulation on WM performance in alcohol-dependent patients (AD), tobacco users (TU) and healthy controls (HC). In a double-blind, sham-controlled study, transcranial direct current stimulation (tDCS) was applied to upregulate right dorsolateral prefrontal cortex (DLPFC) activity. Participants received anodal tDCS with current at an intensity of 1.5 mA for 20 minutes in the active group. A large reference electrode (10x10cm) was chosen to minimize stimulation effects and situated over the bilateral supraorbital area. While being stimulated, participants performed the n-back task as a measure of WM performance. Results revealed no significant differences in WM performance between active and sham stimulated participants. Further, performance in the AD group did not differ from TU and HC. According to previous research, stimulation the left DLPFC may more effective in enhancing WM performance. Our findings suggest that the use of larger reference electrodes can minimize the impact on underlying brain regions.