bluuebunny/crossref_metadata_2025_split huggingface dataset:
Twist-angle dependent dehybridization of momentum-indirect excitons in MoSe2/MoS2 heterostructures
Authors: Sokolowski Nikodem , Palai Swaroop , Dyksik Mateusz , Posmyk Katarzyna , Baranowski Michał , Surrente Alessandro , Maude Duncan , Carrascoso Felix , Cakiroglu Onur , Sanchez Estrella , Schubert Alina , Munuera Carmen , Taniguchi Takashi , Watanabe Kenji , Hagel Joakim , Brem Samuel , Castellanos-Gomez Andres , Malic Ermin , Plochocka Paulina 
Published: June 2023

Abstract
The moiré superlattice has emerged as a powerful way to tune excitonic properties in two-dimensional van der Waals structures. However, the current understanding of the influence of the twist angle for interlayer excitons (IXs) in heterostructures is mainly limited to momentum-direct K–K transitions. In this work, we use a judicious combination of spectroscopy and many-particle theory to investigate the influence of the twist angle on momentum-indirect IXs of a MoSe2/MoS2 heterostructure. Here, the energetically lowest state is a dark and strongly hybridized ΓK exciton. We show that increasing the twist angle from an aligned structure (0∘ or 60∘) gives rise to a large blue shift of the IX, which is a manifestation of the strong dehybridization of this state. Moreover, for small twist angle heterostructures, our photoluminescence measurements reveal contributions from two IX states, which our modelling attributes to transitions from different moiré minibands. Our finding contributes to a better fundamental understanding of the influence of the moiré pattern on the hybridization of momentum-dark IX states, which may be important for applications in moiré-tronics including novel quantum technologies.
A temperature-sensitive plugging material composed of shape memory polymer and self-made gel
Authors: Tang Longhao , Wang Tingyi , Song Huifang , Xu Mingming , Xu Yingbiao , Wang Yuanyuan 
Published: June 2023

Abstract
Polymers with shape memory property and gel with resistance to high temperature can be both used for plugging formation, but they also have shortcomings. Nevertheless, it is possible to mix shape memory polymer(SMP) particles in the gel solution and use formation temperature to stimulate them to complete morphological transformation to achieve the purpose of plugging. This mutual combination method can help them reduce the shortcomings between each other. Here, a series of SMP with different glass transition temperatures and self-made gel were prepared. SMP needs to be prepared into particles to meet the dimensional requirements of plugging materials, but it can also retain shape memory property and pressure bearing capacity. The composition and thermal properties of both SMP and gel were characterized by FTIR and DMA. The plugging performance and mechanism of the composite of SMP and gel were systematically studied. The results show that the addition of SMP could improve the mechanical strength in system, and the viscosity gel can help stabilize the bridging structure formed by SMP particles at cracks. This composite of SMP and gel is expected to be a potential plugging material.
Electrocardiography signal compression using non-decimated stationary wavelet transform-based technique
Authors: Sharma Neenu , Sunkaria Ramesh Kumar 
Published: June 2023

Abstract

Background. In telecardiology, the bio-signal acquisition processing and communication for clinical purposes occupies larger storage and significant bandwidth over a communication channel. Electrocardiograph (ECG) compression with effective reproductivity is highly desired. In the present work, a compression technique for ECG signals with less distortion by using a non-decimated stationary wavelet with a run-length encoding scheme has been proposed. Method. In the present work non-decimated stationary wavelet transform (NSWT) method has been developed to compress the ECG signals. The signal is subdivided into N levels with different thresholding values. The wavelet coefficients having values larger than the threshold are evaluated and the remaining are suppressed. In the presented technique, the biorthogonal (bior) wavelet is employed as it improves the compression ratio as well percentage root means square ratio (PRD) when compared to the existing method and exhibits improved results. After pre-processing, the coefficients are subjected to the Savitzky-Golay filter to remove corrupted signals. The wavelet coefficients are then quantized using dead-zone quantization, which eliminates values that are close to zero. To encode these values, a run-length encoding (RLE) scheme is applied, resulting in compressed ECG signals. Results. The presented methodology has been evaluated on the MITDB arrhythmias database which contains 4800 ECG fragments from forty-eight clinical records. The proposed technique has achieved an average compression ratio of 33.12, PRD of 1.99, NPRD of 2.53, and QS of 16.57, making it a promising approach for various applications. Conclusion. The proposed technique exhibits a high compression ratio and reduces distortion compared to the existing method.
Deep learning model with L1 penalty for predicting breast cancer metastasis using gene expression data
Authors: Kim Jaeyoon , Lee Minhyeok , Seok Junhee 
Published: June 2023

Abstract
Breast cancer has the highest incidence and death rate among women; moreover, its metastasis to other organs increases the mortality rate. Since several studies have reported gene expression and cancer prognosis to be related, the study of breast cancer metastasis using gene expression is crucial. To this end, a novel deep neural network architecture, deep learning-based cancer metastasis estimator (DeepCME), is proposed in this paper for predicting breast cancer metastasis. However, the problem of overfitting occurs frequently while training deep learning models using gene expression data because they contain a large number of genes and the sample size is rather small. To address overfitting, several regularization methods are implemented, such as L1 penalty, batch normalization, and dropout. To demonstrate the superior performance of our model, area under curve (AUC) scores are evaluated and then compared with five baseline models: logistic regression, support vector classifier (SVC), random forest, decision tree, and k-nearest neighbor. Considering results, DeepCME demonstrates the highest average AUC scores in most cross-validation cases, and the average AUC score of DeepCME is 0.754, which is approximately 12.9% higher than SVC, the second-best model. In addition, the 30 most significant genes related to breast cancer metastasis are identified based on DeepCME results and some are discussed in further detail considering the reports from some previous medical studies. Considering the high expense involved in measuring the expression of a single gene, the ability to develop the cost-effective and time-efficient tests using only a few key genes is valuable. Based on this study, we expect DeepCME to be utilized clinically for predicting breast cancer metastasis and be applied to other types of cancer as well after further research.
Walking as a Gendered Practice: Travel and Transgressions in Henry James’s Daisy Miller (1878) and The Wings of the Dove (1902)
Authors: Butt Nadia , Schniedermann Wibke 
Published: June 2023

Abstract
This essay investigates the gendered practice of taking a walk in two works of Henry James, his early success Daisy Miller: A Study (1878) and his later-phase masterpiece The Wings of the Dove (1902). We focus on James’s women protagonists, the titular Daisy Miller and Wings’ Milly Theale and, specifically, their desire to walk unhindered through the European cities they are visiting, Rome and London, respectively. The simple activity of going for a walk in an unknown city, this essay argues, points beyond the scope of the streets traversed; it becomes a practice of self-assertion. Both narratives draw on the deep-seated connotations of transgression and deviance with which travelling women have long been associated. We begin by addressing travel as transgression and look at the cultural-historical context of women travellers in which James places his heroines. Our major objective is to map the ways in which James’s treatment of the woman pedestrian has changed over the decades between the two works. To this end, we explore the gender-determined restrictions to mobility in the two case studies and bring out the pleasure that both protagonists derive from bypassing those restraints, the pleasure of travelling and walking freely, in their own distinct ways.
Genome Resource Announcement of 3 Phylotype I and 14 Phylotype II Ralstonia solanacearum Species Complex Isolates from South America
Authors: Aoun Nathalie , Avalos Jason K. , Cope-Arguello Matthew L. , Enriquez Claudia , Nguyen Trung-Hieu , Olyushinets Alexandra , Subuyuj Gabriel A. , Tom Cloe , Lowe-Power Tiffany M. 
Published: June 2023

The Ralstonia solanacearum species complex is a group of gram-negative bacteria that cause lethal wilting on a broad range of plant species. Ralstonia pathogens were responsible for the Moko disease epidemic in plantains, bananas, and Heliconia sp. in Central and South America in the 1960s. To investigate the genomic diversity of Ralstonia strains isolated from Central and South America during this epidemic, we conducted Illumina whole-genome sequencing on 17 Ralstonia isolates. Our phylogenetic analysis showed that three of the isolates were phylotype I strains and 14 isolates were phylotype IIB strains. This genome announcement provides new genomic resources to investigate pathogen evolution, epidemiology, and virulence. [Formula: see text] The author(s) have dedicated the work to the public domain under the Creative Commons CC0 “No Rights Reserved” license by waiving all of his or her rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law, 2023.
Pilot Testing of Evidence-Based Symptom Management Telehealth Simulation-Based Experiences in an Oncology Nursing Seminar
Authors: Burrell Sherry A. , Ross Jennifer Gunberg , Randall Rachel , Heverly MaryAnn 
Published: June 2023

Abstract
Telehealth simulation-based experiences (T-SBEs) offer one approach to prepare nursing students with the requisite skills to deliver oncology evidence-based symptom management (EBSM) using telecommunication technology. Fourteen baccalaureate nursing students participated in this one-group, pretest/posttest, convergent mixed-methods pilot study with questionnaire variant. Data were collected before and/or after two oncology EBSM T-SBEs using standardized participants. The T-SBEs resulted in significant increases in self-perceived competence, confidence, and self-confidence in clinical decision-making related to oncology EBSM. Qualitative themes included value, application, and preference for in-person SBEs. Future research is warranted to definitively determine the effect of oncology EBSM T-SBEs on student learning.
Diagnosis of Fibrillary Glomerulonephritis with Positive Immunoglobulin A-κ Deposits Presenting as Membranous Nephropathy Using Immunoelectron Microscopy: A Case Report and Literature Review
Authors: Li Shishi , Yan Bing , Liu Fanna 
Published: June 2023

ABSTRACT
Fibrillary glomerulonephritis (FGN) is a rare disease characterized by randomly arranged fibrils with a diameter of 10–30 nm on immunoelectron microscopy. Clinically, renal insufficiency, hypertension, hematuria, and proteinuria are the typical symptoms of FGN. Currently, there are limited treatment options for FGN, and transplant recurrence is common. We reported the case of a middle-aged Chinese woman diagnosed with FGN with positive immunoglobulin A-κ deposits presenting as membranous nephropathy.
Inflammation and Fibrosis in Orbital Inflammatory Disease: A Histopathologic Analysis
Authors: Verma Rohan , Chen Allison J. , Choi Dongseok , Wilson David J. , Grossniklaus Hans E. , Dailey Roger A. , Ng John D. , Steele Eric A. , Planck Stephen R. , Czyz Craig N. , Korn Bobby S. , Kikkawa Don O. , Foster Jill A. , Kazim Michael , Harris Gerald J. , Edward Deepak P. , Al Maktabi Azza , Rosenbaum James T. 
Published: June 2023

Purpose:
The purpose of this study was to compare the histopathologic inflammation and fibrosis of orbital adipose tissue in orbital inflammatory disease (OID) specimens.

Methods:
In this retrospective cohort study, inflammation, and fibrosis in orbital adipose tissue from patients with thyroid-associated orbitopathy (TAO), granulomatosis with polyangiitis (GPA), sarcoidosis, nonspecific orbital inflammation (NSOI), and healthy controls were scored by 2 masked ocular pathologists. Both categories were scored on a scale of 0 to 3 with scoring criteria based on the percentage of specimens containing inflammation or fibrosis, respectively. Tissue specimens were collected from oculoplastic surgeons at 8 international centers representing 4 countries. Seventy-four specimens were included: 25 with TAO, 6 with orbital GPA, 7 with orbital sarcoidosis, 24 with NSOI, and 12 healthy controls.

Results:
The mean inflammation and fibrosis scores for healthy controls were 0.0 and 1.1, respectively. Orbital inflammatory disease groups’ inflammation (I) and fibrosis (F) scores, formatted [I, F] with respective p-values when compared to controls, were: TAO [0.2, 1.4] (p = 1, 1), GPA [1.9, 2.6] (p = 0.003, 0.009), sarcoidosis [2.4, 1.9] (p = 0.001, 0.023), and NSOI [1.3, 1.8] (p ≤ 0.001, 0.018). Sarcoidosis had the highest mean inflammation score. The pairwise analysis demonstrated that sarcoidosis had a significantly higher mean inflammation score than NSOI (p = 0.036) and TAO (p < 0.0001), but no difference when compared to GPA. GPA had the highest mean fibrosis score, with pairwise analysis demonstrating a significantly higher mean fibrosis score than TAO (p = 0.048).

Conclusions:
Mean inflammation and fibrosis scores in TAO orbital adipose tissue samples did not differ from healthy controls. In contrast, the more “intense” inflammatory diseases such as GPA, sarcoidosis, and NSOI did demonstrate higher histopathologic inflammation and fibrosis. This has implications in prognosis, therapeutic selection, and response monitoring in orbital inflammatory disease.
New strategies to Reduce Unnecessary Antibiotic Use in the NICU: A Quality Improvement Initiative
Authors: Pantoja Alfonso , Sveum Scott , Frost Sandra , Duran Amanda , Burks Jeanne , Schernecke Christi , Feinberg Michelle 
Published: June 2023

Introduction:
Early-onset sepsis (EOS) and late-onset Sepsis (LOS) are common diagnoses entertained in sick newborns treated in neonatal intensive care units (NICUs), and antibiotics are the medications most prescribed in NICUs. Antibiotic stewardship programs have an important impact on limiting unnecessary antibiotic use.

Methods:
Following the Model for Improvement, between 2/1/16 and 1/31/17, at a level 3 NICU, a multidisciplinary team implemented PDSA cycles to promote antibiotic stewardship practices for newborns at risk of EOS and LOS. The main goal was to decrease the antibiotic usage rate (AUR) safely. Primary strategies included discontinuing antibiotics within 24 hours of life if the newborn was stable, and the blood culture was negative for EOS and implementing an “antibiotic time-out” during rounds.

Results:
For all newborns admitted to our NICU, the AUR decreased, for EOS from 137 to 32 days per 1000 patient days (77% reduction) and for LOS from 277 to 121 days per 1000 patient days (56% reduction). We demonstrated the sustainability of both EOS-AUR and LOS-AUR during the 2 years postcompletion of the intervention period. There were no adverse effects of reducing the AUR.

Conclusion:
Interventions that reduce unnecessary antibiotic use in the NICU are safe and prevent excessive antibiotic exposure.
SEVERE BURN-INDUCED MITOCHONDRIAL RECRUITMENT OF CALPAIN CAUSES ABERRANT MITOCHONDRIAL DYNAMICS AND HEART DYSFUNCTION
Authors: Zhang Ran-Ran , Zhang Jing-Long , Li Qiao , Zhang Shu-Miao , Gu Xiao-Ming , Niu Wen , Zhou Jing-Jun , Zhou Lyu-Chen 
Published: June 2023

ABSTRACT
Mitochondrial damage is an important cause of heart dysfunction after severe burn injury. However, the pathophysiological process remains unclear. This study aims to examine the mitochondrial dynamics in the heart and the role of μ-calpain, a cysteine protease, in this scenario. Rats were subjected to severe burn injury treatment, and the calpain inhibitor MDL28170 was administered intravenously 1 h before or after burn injury. Rats in the burn group displayed weakened heart performance and decreased mean arterial pressure, which was accompanied by a diminishment of mitochondrial function. The animals also exhibited higher levels of calpain in mitochondria, as reflected by immunofluorescence staining and activity tests. In contrast, treatment with MDL28170 before any severe burn diminished these responses to a severe burn. Burn injury decreased the abundance of mitochondria and resulted in a lower percentage of small mitochondria and a higher percentage of large mitochondria. Furthermore, burn injury caused an increase in the fission protein DRP1 in the mitochondria and a decrease in the inner membrane fusion protein OPA1. Similarly, these alterations were also blocked by MDL28170. Of note, inhibition of calpain yielded the emergence of more elongated mitochondria along with membrane invagination in the middle of the longitude, which is an indicator of the fission process. Finally, MDL28170, administered 1 h after burn injury, preserved mitochondrial function and heart performance, and increased the survival rate. Overall, these results provided the first evidence that mitochondrial recruitment of calpain confers heart dysfunction after severe burn injury, which involves aberrant mitochondrial dynamics.
The evolution and development of a robotic acute care surgery program
Authors: Torres Crisanto M. , Florecki Katherine , Haghshenas Jafar , Manukyan Mariuxi , Kent Alistair , Lawrence Chuck , Sakran Joseph V. 
Published: June 2023

BACKGROUND
Acute care surgeons perform more than 850,000 operations annually on emergency general surgery patients in the United States. Emergency general surgery conditions are associated with a disproportionate excess of patient complications and death. Innovative quality improvement strategies have focused on addressing the excess morbidity and mortality among this patient population. Minimally invasive surgical techniques have been shown to reduce the burden experienced by emergency general surgery patients. Still, limited adoption by acute care surgeons has restricted this application’s potential. An institutional robotics acute care surgery program provides acute care surgeons additional opportunities to expand minimally invasive surgery access to emergency general surgery patients irrespective of the time or day of the week.

METHODS
A robotics acute care surgery program was developed and implemented at a high-volume academic institution within the division of trauma and acute care surgery.

RESULTS
Three attending surgeons and two fellows within the trauma and acute care surgery division had successfully completed a defined robotics clinical pathway. As a result, around-the-clock use of a robotic surgical platform for emergency general surgery cases was implemented with routine use by trained robotic acute care surgeons and practicing fellows.

CONCLUSION
The advancement of robotic surgical technology has opened new avenues for surgical application in the emergency setting. The development of a robotic acute care surgery program allows acute care surgeons to diversify their practice while providing greater access to minimally invasive approaches for emergency general surgery patients.
Top-down Proteomics of 10,000 Single Brain Cells
Authors: Su Pei , Hollas Michael A. R. , Rubakhin Stanislav , Butun Fatma Ayaloglu , Greer Joseph B. , Early Bryan P. , Fellers Ryan T. , Caldwell Michael A. , Sweedler Jonathan V. , Kafader Jared O. , Kelleher Neil L. 
Published: June 2023

AbstractWe introduce single-cell Proteoform imaging Mass Spectrometry (scPiMS), which realizes the benefit of direct analysis of intact proteins to process 10,836 single cells from the rat hippocampus. This new platform addresses the throughput bottleneck for single cell proteomics using mass spectrometry, boosting cell processing rates by >20-fold in the field. We identified 169 proteoforms <70 kDa from single brain cells and classified 2758 of them as neurons, astrocytes or microglia cell types.
CULTURAL CONSANGUINITY AS CAUSE OF β-THALASSEMIA PREVALENCE IN POPULATION
Authors: Aslamkhan Muhammad , Qadeer Muhammad Imran , Akhtar Muhammad Shoaib , Chudhary Shafiq Ahmad , Mariam Maida , Ali Zain , Khalid AbdurRauf , Irfan Muhammad , Khan Yasin 
Published: June 2023

AbstractBackgroundSome 200 million people worldwide have haemoglobinopathies of some sort. Pakistan, where 80% consanguinity prevails because of marriages within caste groups that are anthropologically same. The study aims to reveal the impact of consanguinity on thalassemia in various castes in Punjab, Pakistan.Subjects and Methods262 β-thalassemic patient’s families were studied. Patients were registered in various Thalassemia Blood Transfusion Hospitals/Centers, in the metropolitan city of Lahore, Punjab, Pakistan. Patients and parents were interviewed using structured questionnaire regarding information about name, age, sex, ethnicity (caste), educational status, consanguinity of parents, number of progenies, health status of children, pregnancy wastage and family history.ResultsThe 262 (couples) parents of β-thalassemic patients revealed 96% consanguineous marriages with 72% first cousins, 10% distant blood relatives and 14%Bradari. Inter-castes marriages were 4% only. These families produced 1646 children, 582 males and 464 females. Of these, 303 boys and 293 girls are healthy, while 279 boys and 171 girls are thalassemic. In 26 castes, the prevalence of thalassemia varied from 21% to 3%. Rajput tribe on top followed by Arain.ConclusionThalassemia is widely spread in Pakistani population. Its prevalence varied in caste groups due to endogamy, a major impact on the prevalence of thalassemia.
Effect of Terpenes fromPoria Cocos: Verifying Modes of Action against Alzheimer’s disease Using Molecular Docking, Drug-induced Transcriptomes and Diffusion Network
Authors: Park Musun , Lee Seo-Young , Lee Haeseung , Yi Jin-Mu 
Published: June 2023

AbstractPoria cocosis used to treat various diseases because of its unique terpenes. However, no study verifying its modes of action using only its compounds based onin silicoexperiments has been conducted. Here, molecular docking and drug-induced transcriptome analyses were performed to confirm the modes of action ofPoria cocos. Additionally, a diffusion network analysis method was proposed to confirm its modes of action against Alzheimer’s. First,Poria cocosterpenes were collected from standard databases for molecular docking. They were then used for large-scale molecular docking using druggable proteomes, and the modes of action of lanostane and seco-lanostane, unique toPoria cocos, were confirmed. Additionally, the brain cell line was treated withPoria cocosto producePoria cocos-induced transcriptome data, and the transcriptome-based modes of action ofPoria cocoswere confirmed. Finally, a diffusion network was constructed using Alzheimer’s, which acts on both modes of action, and submodules of Alzheimer’s with which terpenes interact were identified. It was confirmed thatPoria cocosacts on the Wnt signaling pathway, Zn-to-anterograde axonal transport, autophagy impairment, insulin and AGE-RAGE signaling pathways, and apoptosis mechanisms. This study identified the modes of action ofPoria cocosusing biological data andin silicomethods.