bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential distribution of Leptotrombidium scutellare in Yunnan and Sichuan Provinces, China, and its association with mite-borne disease transmission
Authors: Song Wen-Yu , Lv Yan , Yin Peng-Wu , Yang Yi-Yu , Guo Xian-Guo 
Published: May 2023

Abstract
Background
Leptotrombidium scutellare is one of the six main vectors of scrub typhus in China and is a putative vector of hemorrhagic fever with renal syndrome (HFRS). This mite constitutes a large portion of the chigger mite community in southwest China. Although empirical data on its distribution are available for several investigated sites, knowledge of the species’ association with human well-being and involvement in the prevalence of mite-borne diseases remains scarce.

Methods
Occurrence data on the chigger mite were obtained from 21 years (2001–2021) of field sampling. Using boosted regression tree (BRT) ecological models based on climate, land cover and elevation variables, we predicted the environmental suitability for L. scutellare in Yunnan and Sichuan Provinces. The potential distribution range and shifts in the study area for near-current and future scenarios were mapped and the scale of L. scutellare interacting with human activities was evaluated. We tested the explanatory power of the occurrence probability of L. scutellare on incidences of mite-borne diseases.

Results
Elevation and climate factors were the most important factors contributing to the prediction of the occurrence pattern of L. scutellare. The most suitable habitats for this mite species were mainly concentrated around high-elevation areas, with predictions for the future showing a trend towards a reduction. Human activity was negatively correlated with the environmental suitability of L. scutellare. The occurrence probability of L. scutellare in Yunnan Province had a strong explanatory power on the epidemic pattern of HFRS but not scrub typhus.

Conclusions
Our results emphasize the exposure risks introduced by L. scutellare in the high-elevation areas of southwest China. Climate change may lead to a range contraction of this species towards areas of higher elevation and lessen the associated exposure risk. A comprehensive understanding of the transmission risk requires more surveillance efforts.

Graphical Abstract
Two-year imaging outcomes from a phase 3 randomized trial of secukinumab in patients with non-radiographic axial spondyloarthritis
Authors: Braun Juergen , Blanco Ricardo , Marzo-Ortega Helena , Gensler Lianne S. , Van den Bosch Filip , Hall Stephen , Kameda Hideto , Poddubnyy Denis , van de Sande Marleen , van der Heijde Désirée , Zhuang Tingting , Stefanska Anna , Readie Aimee , Richards Hanno B. , Deodhar Atul 
Published: May 2023

Abstract
Background
Radiographic progression and course of inflammation over 2 years in patients with non-radiographic axial spondyloarthritis (nr-axSpA) from the phase 3, randomized, PREVENT study are reported here.

Methods
In the PREVENT study, adult patients fulfilling the Assessment of SpondyloArthritis International Society classification criteria for nr-axSpA with elevated CRP and/or MRI inflammation received secukinumab 150 mg or placebo. All patients received open-label secukinumab from week 52 onward. Sacroiliac (SI) joint and spinal radiographs were scored using the modified New York (mNY) grading (total sacroiliitis score; range, 0–8) and modified Stoke Ankylosing Spondylitis Spine Score (mSASSS; range, 0–72), respectively. SI joint bone marrow edema (BME) was assessed using the Berlin Active Inflammatory Lesions Scoring (0–24) and spinal MRI using the Berlin modification of the AS spine MRI (ASspiMRI) scoring (0–69).

Results
Overall, 78.9% (438/555) of patients completed week 104 of the study. Over 2 years, minimal changes were observed in total radiographic SI joint scores (mean [SD] change, − 0.04 [0.49] and 0.04 [0.36]) and mSASSS scores (0.04 [0.47] and 0.07 [0.36]) in the secukinumab and placebo-secukinumab groups. Most of the patients showed no structural progression (increase ≤ smallest detectable change) in SI joint score (87.7% and 85.6%) and mSASSS score (97.5% and 97.1%) in the secukinumab and placebo-secukinumab groups. Only 3.3% (n = 7) and 2.9% (n = 3) of patients in the secukinumab and placebo-secukinumab groups, respectively, who were mNY-negative at baseline were scored as mNY-positive at week 104. Overall, 1.7% and 3.4% of patients with no syndesmophytes at baseline in the secukinumab and placebo-secukinumab group, respectively, developed ≥ 1 new syndesmophyte over 2 years. Reduction in SI joint BME observed at week 16 with secukinumab (mean [SD], − 1.23 [2.81] vs − 0.37 [1.90] with placebo) was sustained through week 104 (− 1.73 [3.49]). Spinal inflammation on MRI was low at baseline (mean score, 0.82 and 1.07 in the secukinumab and placebo groups, respectively) and remained low (mean score, 0.56 at week 104).

Conclusion
Structural damage was low at baseline and most patients showed no radiographic progression in SI joints and spine over 2 years in the secukinumab and placebo-secukinumab groups. Secukinumab reduced SI joint inflammation, which was sustained over 2 years.

Trial registration
ClinicalTrials.gov, NCT02696031.
The mediating role of perceived behavioral control in the relationship between entrepreneurship education and entrepreneurial intentions of university students in Ethiopia
Authors: Aga Messele Kumilachew 
Published: May 2023

AbstractUnemployment of graduates from higher education institutions has become a common phenomenon in Ethiopia. To minimize this problem, entrepreneurship development and promoting entrepreneurial ecosystems have been considered as a remedy. Among others, this could be achieved through fostering entrepreneurship education. Hence, the purpose of this paper is to investigate the mediating role of perceived behavioral control in the relationship between entrepreneurship education and entrepreneurial intentions in Ethiopian Universities. Explanatory research design was used and data were collected using a self-administered questionnaire from a sample of 335 undergraduate students who have taken the course entrepreneurship in four Ethiopian universities. Structural Equation Modeling (SEM) approach using AMOS software was employed and confirmed both measurement and structural model fit before analysis. Then, the findings revealed that entrepreneurship education has a positive and significant effect on entrepreneurial intentions and perceived behavioral control. Moreover, perceived behavioral control positively predicts entrepreneurial intentions. The findings further explained that perceived behavioral control has a partial mediating effect in the relationship between entrepreneurship education and entrepreneurial intentions. Therefore, universities in Ethiopia should work on different initiatives that enhance knowledge, attitude, and skills of students on entrepreneurship that could help them to develop perceived behavioral control so as to enhance their intentions to become nascent entrepreneur after their graduation.
Geography, not lifestyle, explains the population structure of free-living and host-associated deep-sea hydrothermal vent snail symbionts
Authors: Hauer Michelle A. , Breusing Corinna , Trembath-Reichert Elizabeth , Huber Julie A. , Beinart Roxanne A. 
Published: May 2023

AbstractBackgroundMarine symbioses are predominantly established through horizontal acquisition of microbial symbionts from the environment. However, genetic and functional comparisons of free-living populations of symbionts to their host-associated counterparts are sparse. Here, we assembled the first genomes of the chemoautotrophic gammaproteobacterial symbionts affiliated with the deep-sea snailAlviniconcha hesslerifrom two separate hydrothermal vent fields of the Mariana Back-Arc Basin. We used phylogenomic and population genomic methods to assess sequence and gene content variation between free-living and host-associated symbionts.ResultsOur phylogenomic analyses show that the free-living and host-associated symbionts ofA. hesslerifrom both vent fields are populations of monophyletic strains from a single species. Furthermore, genetic structure and gene content analyses indicate that these symbiont populations are differentiated by vent field rather than by lifestyle.ConclusionTogether, this work suggests that, despite the potential influence of host-mediated acquisition and release processes on horizontally transmitted symbionts, geographic isolation and/or adaptation to local habitat conditions are important determinants of symbiont population structure and intra-host composition.
Differences in sleep patterns between patients with anorexia nervosa and healthy controls: a cross-sectional study
Authors: Kleppe Malin Mandelid , Kessler Ute , Rekkedal Guro Årdal , Skjåkødegård Hanna Flækøy , Danielsen Yngvild Sørebø 
Published: May 2023

Abstract
Background
Sleep difficulties are common in patients with anorexia nervosa (AN), but objective assessments have mostly been performed in hospital and laboratory settings. We aimed to identify differences in sleep patterns between patients with AN and healthy controls (HC) in their free-living environments, and potential associations between sleep patterns and clinical symptoms in patients with AN.

Methods
This cross-sectional study analyzed 20 patients with AN prior to them starting outpatient treatment and 23 HC. Sleep patterns were measured objectively using an accelerometer (Philips Actiwatch 2) for 7 consecutive days. Average sleep onset, sleep offset, total sleep time, sleep efficiency, wake after sleep onset (WASO) and mid-sleep awakenings lasting ≥ 5 min were compared between patients with AN and HC using nonparametric statistical analyses. Associations of sleep patterns with body mass index, eating-disorder symptoms, eating-disorder-associated impairment, and symptoms of depression were assessed in the patient group.

Results
Compared with HC, patients with AN had shorter WASO [median (interquartile range(IQR)): 33 vs. 42 min], but a longer average duration of mid-sleep awakenings lasting ≥ 5 min [median (IQR): 9 vs. 6 min, p = 0.006] and had more nights with no sleep (six nights in four patients with AN vs. zero nights in HC). There were no differences between patients with AN and HC regarding other sleep parameters and no significant correlations between sleep patterns and clinical parameters in patients with AN. However, HC presented a Intraindividual variability pattern that was closer to a normal distribution, whereas patients with AN tended to either have very regular or large variability in sleep onset time (AN; n = 7 < 25th percentile and n = 8 > 75th percentile vs. HC; n = 4 < 25 percentile and n = 3 > 75th percentile) during the week of sleep recordings.

Conclusion
Patients with AN seem to spend more time awake during the night and have more nights without sleep than do HC, even though their average weekly sleep duration did not differ from that in HC. The intraindividual variability in sleep pattern seems to be an important parameter that should be assessed when studying sleep in patients with AN.
Trial registration ClinicalTroals.gov. Identifier: NCT02745067. Registered: April 20, 2016.
Abrupt water temperature increases near seafloor during the 2011 Tohoku earthquake
Authors: Inazu Daisuke , Ito Yoshihiro , Hino Ryota , Tanikawa Wataru 
Published: May 2023

AbstractWe investigated temperature records associated with seafloor pressure observations at eight stations that experienced the 2011 Mw 9 Tohoku earthquake near its epicenter. The temperature data were based on the temperature measured inside the pressure transducer. We proposed a method to estimate ambient water temperature from the internal temperature using an equation of heat conduction. The estimated seafloor water temperature showed remarkable anomalies, especially increases several hours after the Mw 9 earthquake. A station of P03 (sea depth of 1.1 km) showed an abrupt temperature increase of + 0.19 °C that occurred ~ 3 h after the earthquake, which lasted for several hours. At stations of GJT3 (sea depth of 3.3 km) and TJT1 (sea depth of 5.8 km), there were abrupt temperature anomalies of + 0.20 °C and + 0.10 °C that began to occur 3–4 h after the earthquake. These anomalies both decayed to their original levels over a few tens of days. During the decay processes, only TJT1 showed several intermittent temperature rises. A water temperature anomaly within + 0.03 °C was found up to ~ 500 m above TJT1 2 weeks after the earthquake. There was no significant anomaly at the other five stations. Processes to cause these seafloor temperature anomalies were discussed. The temperature anomaly of P03 was reasonably caused by a tsunami-generated turbidity current, as also suggested by a previous study. Meanwhile, we proposed a scenario that the abrupt temperature anomalies of GJT3/TJT1 and the intermittent anomalies of TJT1 were caused by warm water discharges from the subseafloor. The pathways of the warm water were probably composed of the branch normal fault between GJT3 and TJT1, the reverse fault near TJT1, the backstop interface, and perhaps reverse faults at the frontal prism. The proposed scenario was almost compatible with other studies based on epicentral observations. We estimated the heat properties of the initial temperature anomalies of GJT3/TJT1. The estimated heat source might be explained by that most of the geothermal fluids trapped in those fault pathways were discharged to the seafloor immediately after the earthquake. The onsets of the subsequent intermittent anomalies of TJT1 were possibly activated by low or falling ocean tidal loading.
A case of Amyand hernia at the Central Hospital of Yaounde and review of the literature
Authors: Fouda J. C. , Owon’Abessolo Philip Fernandez , Nyanit Bob Dorcas , Mekeme Mekeme Junior Barthelemy , Savom P. , Ranibel A. , Mbassi A. A. , Bwelle G. , Bang G. A. , Fouda P. J. , Mouafo Tambo Faustin , Essomba A. 
Published: May 2023

Abstract
Introduction
Amyand's hernia is defined as an inguinal hernia, containing the appendix in the hernia sac. It is a rare form of hernia. Its management is increasingly codified.

Clinical history
A 5-year-old patient with a non-remarkable past history was brought for consultation with an intermittent inguino-scrotal swelling and discomfort. Clinical examination revealed a non-tender inguino-scrotal swelling with positive transillumination. A conclusion of a communicating hydrocele was made; hence, an indication for surgery. Per operatively, we had as findings the appendix present within, and linked to the hernia sac. We performed an appendectomy and a high ligation of the hernia sac. The post-operative evolution was favourable. Anatomopathological analysis revealed a catarrhal appendix.

Conclusion
Amyand's hernia remains a rare pathology that can be seen in children with a persistent peritoneo-vaginal canal. Dissection of the hernia sac must be carried out carefully since it is most often discovered intraoperatively and accidental injury to the appendix, which is attached to the wall of the hernia sac can lead to serious complications.
Emerging biomaterials for tumor immunotherapy
Authors: Xiao Minna , Tang Qinglai , Zeng Shiying , Yang Qian , Yang Xinming , Tong Xinying , Zhu Gangcai , Lei Lanjie , Li Shisheng 
Published: May 2023

Abstract

Background
The immune system interacts with cancer cells in various intricate ways that can protect the individual from overproliferation of cancer cells; however, these interactions can also lead to malignancy. There has been a dramatic increase in the application of cancer immunotherapy in the last decade. However, low immunogenicity, poor specificity, weak presentation efficiency, and off-target side effects still limit its widespread application. Fortunately, advanced biomaterials effectively contribute immunotherapy and play an important role in cancer treatment, making it a research hotspot in the biomedical field.

Main body
This review discusses immunotherapies and the development of related biomaterials for application in the field. The review first summarizes the various types of tumor immunotherapy applicable in clinical practice as well as their underlying mechanisms. Further, it focuses on the types of biomaterials applied in immunotherapy and related research on metal nanomaterials, silicon nanoparticles, carbon nanotubes, polymer nanoparticles, and cell membrane nanocarriers. Moreover, we introduce the preparation and processing technologies of these biomaterials (liposomes, microspheres, microneedles, and hydrogels) and summarize their mechanisms when applied to tumor immunotherapy. Finally, we discuss future advancements and shortcomings related to the application of biomaterials in tumor immunotherapy.

Conclusion
Research on biomaterial-based tumor immunotherapy is booming; however, several challenges remain to be overcome to transition from experimental research to clinical application. Biomaterials have been optimized continuously and nanotechnology has achieved continuous progression, ensuring the development of more efficient biomaterials, thereby providing a platform and opportunity for breakthroughs in tumor immunotherapy.

Graphical Abstract
Korean language teachers’ vulnerability over English competency in Korean-only classrooms
Authors: Song Juyoung 
Published: May 2023

AbstractThe recent trend of the internationalization of higher education has increased the significance of English as a medium of instruction and communication on campus in non-English speaking countries. Within this context, this study explores emotional vulnerability of teachers of Korean as a second language (KSL) over their foreign language competency, particularly English. Analysis of interviews of twelve KSL teachers demonstrates these teachers’ divergent ways of interpreting and implementing Korean-only instruction, a prevalent norm within the language program, according to their perceived foreign language competency and relevant emotional vulnerability. KSL teachers with proficiency in other foreign language(s) tended to challenge the monolingual norm by utilizing their bilingual skills and experiences as resources for their teaching. Monolingual KSL teachers interpreted Korean-only narrowly and supported a monolingual immersion approach as a way to secure their teacher authority. Regardless of their attitudes towards the Korean-only instruction, however, most teachers experienced various levels of anxiety concerning their perceived lack of adequate English proficiency in the KSL classroom. The results suggest how second language teachers struggle to maintain legitimacy and authority against the hegemony of English in non-English second language contexts, providing implications for the language teacher education.
Virtual reality in the management of patients with low back and neck pain: a retrospective analysis of 82 people treated solely in the metaverse
Authors: Orr Eran , Arbel Tal , Levy Miki , Sela Yaron , Weissberger Omer , Liran Omer , Lewis Jeremy 
Published: May 2023

Abstract
Background
Clinically, neck pain disorders (NPD) and non-specific low back pain (NS-LBP) are respectively the fourth and first most common conditions associated with the greatest number of years lived with disability. Remote delivery of care may benefit healthcare sustainability, reduce environmental pollution, and free up space for those requiring care non-virtual care.

Methods
A retrospective analysis was performed on 82 participants with NS-LBP and/or NPD who received exercise therapy delivered solely in the metaverse using virtually reality. The study was to determine if this was achievable, safe, had appropriate outcome measures that could be collected, and if there was any early evidence of beneficial effects.

Results
The study demonstrated that virtual reality treatment delivered via the metaverse appears to be safe (no adverse events or side effects). Data for more than 40 outcome measures were collected. Disability from NS-LBP was significantly reduced (Modified Oswestry Low Back Pain Disability Index) by 17.8% (p < 0.001) and from NPD (Neck Disability Index) by 23.2% (p = 0.02).

Conclusions
The data suggest that this method of providing exercise therapy was feasible, and safe (no adverse events reported), that complete reports were obtained from a large selection of patients, and that software acquired outcomes were obtainable over a range of time points. Further prospective research is necessary to better understand our clinical findings.
Effect of shipping trade on economic growth in Nigeria: the Vector Error Correction Model (VECM) approach
Authors: Adenigbo Adedotun Joseph , Mageto Joash , Luke Rose 
Published: May 2023

AbstractThe maritime industry is significant to the growth and development of nations. The relationship between shipping trade and economic growth in Nigeria is acknowledged in the literature. Still, the need to emphasise the role of shipping import and export volume and exchange rate volatility in Nigeria’s economic growth remains. The economic growth and development level that a maritime nation will derive from its ocean depends on its import and export volumes in the face of exchange rate volatility. Using the Vector Error Correction Model, this study analyses the effect of shipping trade on economic growth in Nigeria from 1970 to 2020. The study examines the effect of seaport imports, exports, and real exchange rates on GDP to determine if Nigeria’s economic growth is sustainable, that is if the current pattern of shipping imports and exports for economic growth will not hamper future economic development. The cointegration test established a short- and long-term causality from import, export and exchange rates to GDP. The result showed that Nigeria’s economic growth is import-dependent and that, in the long run, import and exchange rates significantly affect GDP. The study further indicates that the present export volume does not significantly contribute to GDP growth. The results imply that building an economic system on an import-dominated trade system is not sustainable for future development. The study recommended strategic initiatives to maintain the economic growth rate while promoting export through local production.
Leafhopper transmits soybean stay-green associated virus to leguminous plants
Authors: Yin Jinlong , Hu Zhuangzhuang , Xu Shuqi , Hong Xin , Qiu Yanglin , Cheng Xinge , Wang Liqun , Shen Weiliang , Zhi Haijian , Li Kai , Xu Kai 
Published: May 2023

AbstractA novel geminivirus, soybean stay-green associated virus (SoSGV), was previously shown to cause soybean delayed senescence and is associated with the incidence of soybean stay-green syndrome. The modes of SoSGV transmission were not yet known. We captured insects belonging to 24 distinct species in a soybean field with the SoSGV outbreak and detected the presence of SoSGV only in leafhoppers and bean bugs (Riptortus pedestris). Caged feeding experiments using captured leafhoppers and bean bugs from soybean fields showed that leafhoppers, but not bean bugs, are vectors transmitting SoSGV. The common brown leafhopper (Orosius orientalis) is identified as the dominant leafhopper species and can establish colonies feeding on soybean plants in experimental conditions. An investigation of SoSGV defective DNA revealed that soybean genomic DNA fragments could be inserted into the SoSGV genome, while sequences from wild soybean, red bean, and cowpea were also identified. We further showed that the common brown leafhopper could transmit SoSGV to wild soybean and red bean plants, emphasizing a vector’s role of the leafhopper in the transmission of SoSGV in the field.