bluuebunny/crossref_metadata_2025_split huggingface dataset:
Same day discharge versus overnight observation following chronic total occlusion percutaneous coronary intervention: Insights from the PROGRESS‐CTO registry
Authors: Simsek Bahadir , Khatri Jaikirshan , Young Laura , Kostantinis Spyridon , Karacsonyi Judit , Rempakos Athanasios , Alaswad Khaldoon , Jaffer Farouc A. , Doshi Darshan , Gorgulu Sevket , Goktekin Omer , Kerrigan Jimmy , Haddad Elias V. , Rinfret Stephane , Jaber Wissam A. , Nicholson William , Krestyaninov Oleg , Khelimskii Dimitrii , Choi James W. , Patel Taral N. , Jefferson Brian K. , Bradley Steven M. , Rao Sunil V. , Rangan Bavana V. , Allana Salman S. , Sandoval Yader , Burke M. Nicholas , Brilakis Emmanouil S. , Poommipanit Paul B. ,   the PROGRESS‐CTO investigators
Published: March 2023

AbstractBackgroundSame day discharge (SDD) following chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has received limited study.MethodsWe evaluated the clinical, angiographic, and procedural characteristics of patients discharged the same day versus those kept for overnight observation in the Prospective Global Registry for the Study of Chronic Total Occlusion Intervention (PROGRESS‐CTO, NCT02061436).ResultsOf the 7181 patients who underwent CTO PCI, 943 (13%) had SDD. The SDD rate increased from 3% in 2015 to 21% in 2022. Patients with SDD were less likely to have a history of heart failure (21% vs. 26%,p = 0.005), chronic lung disease (10% vs. 15%,p = 0.001), or anemia (12% vs. 19%,p < 0.001). Technical success (87% vs. 88%,p = 0.289) was similar, but in‐hospital major adverse cardiovascular events (0.0% vs. 0.4%,p = 0.041) were lower in SDD. In multivariable logistic regression analysis, prior myocardial infarction odds ratio (OR): 0.71 (95% confidence interval [CI]: 0.59–0.87,p = 0.001), chronic lung disease OR: 0.64 (95% CI: 0.47–0.88,p = 0.006), and increasing procedure time OR: 0.93 (95% CI: 0.91–0.95,p < 0.001, per 10‐min increase) were associated with overnight observation, while radial‐only access OR: 2.45 (95% CI: 2.03–2.96,p < 0.001) had the strongest association with SDD. In the SDD, 2 (0.4%) of 514 patients were readmitted, due to retroperitoneal bleeding (n = 1) and ischemic stroke (n = 1).ConclusionThe overall frequency of SDD after CTO PCI was 13% and has been increasing over time. SDD is feasible in select patients following CTO PCI, and radial‐only access had the strongest association with SDD.
Successful adalimumab graded challenge after allergic delayed reaction to golimumab in a woman with rheumatoid arthritis
Authors: Rivolta Federica , Sangalli Andrea , Cappelletti Camilla , Chiei Gallo Alessandra , Dubini Marco , Pravettoni Valerio 
Published: March 2023

AbstractA graded challenge with adalimumab could be safe in case of a delayed allergic reaction to golimumab, after a detailed allergological evaluation and the exclusion of allergic sensitization using skin tests.
Synovial calprotectin: A potentially useful biomarker for the diagnosis of Kingella kingae native arthritis
Authors: Leroy Anne‐Gaëlle , Bémer Pascale , Decante Cyrille , Ruffier d’Epenoux Louise , Tessier Eve , Crenn Vincent , Guillouzouic Aurélie , Corvec Stéphane ,   The CRIOGO Microbiology Study Group
Published: March 2023

AbstractKingella kingae is a bacteria involved in developing arthritis in children. Its diagnosis remains difficult. We report a case for which a new biomarker, calprotectin measured in the synovial fluid, was strongly positive and a specific molecular test was the only way to diagnose it specifically.
Novel quantum key distribution and attribute based encryption for cloud data security
Authors: Verma Garima , Kumar Ashutosh 
Published: March 2023

SummaryImprovement of privacy and security in data centers is challenging with proficient safety key managing. So as to resolve this issue, data centers require proficient quantum cryptographic techniques with authentication methods that are suitable to improve the privacy and security with lesser intricacy. In addition, quantum cryptography (QC) offers maximal security with lesser complication, which raises the security strength and storing capability of big data. This work intends to introduce a QC oriented data security model in cloud via electing the optimal private key. Here, attribute based encryption (ABE) is performed for ensuring better data transmission among the nodes in cloud. For key generation in ABE, improved QKD is adopted in this work. Depending upon this, the decryption and encryption is done. Moreover, for optimal secret key selection in ABE, self‐modified Aquila optimization (SM‐AO) scheme is deployed. Further, analysis is done depending upon varied metrics.
Does adding community science observations to museum records improve distribution modeling of a rare endemic plant?
Authors: Gaier Andrew G. , Resasco Julian 
Published: March 2023

AbstractUnderstanding the ranges of rare and endangered species is central to conserving biodiversity in the Anthropocene. Species distribution models (SDMs) have become a common and powerful tool for analyzing species–environment relationships across geographic space. Although evaluating the distribution of rare species is integral to their conservation, this can be difficult when limited distribution data are available. Community science platforms, such as iNaturalist, have emerged as alternative sources for species occurrence data. Although these observations are often thought to be of lower quality than those of natural history collections, they may have potential for improving SDMs for species with few occurrence records from collections. Here, we investigate the utility of iNaturalist data for developing SDMs for a rare high‐elevation plant, Telesonix jamesii. Because methods for modeling rare species are limited in the literature, five different modeling techniques were considered, including profile methods, statistical models, and machine learning algorithms. The inclusion of iNaturalist data doubled the number of usable records for T. jamesii. We found that a random forest (RF) model using ensemble training data performed the highest of any model (area under curve = 0.98). We then compared the performance of RF models that use only natural history training data and those that use a combination of natural history (herbarium specimens) and iNaturalist training data. All models heavily relied on climate data (mean temperature of driest quarter, and precipitation of the warmest quarter), indicating that this species is under threat as climate continues to change. Validation datasets affected model fits as well. Models using only herbarium data performed slightly poorer when evaluated with cross‐validation than when validated externally with iNaturalist data. This study can serve as a model for future SDM studies of species with similar data limitations.
Evaluating Golden‐winged Warbler use of alder and aspen communities managed with shearing in the western Great Lakes
Authors: Buckardt Thomas Anna , McNeil Darin J. , Larkin Jeffery L. , Johnson Kirsten E. , Roth Amber M. 
Published: March 2023

AbstractBest management practices are often written by researchers to guide land managers and landowners in the creation of habitat for wildlife species of interest. These documents are based on research evaluating the habitat needs of a species, but they also describe tools and strategies managers can implement to create or restore desired conditions. Shrub and sapling shearing is a management practice often used to improve habitat for early‐successional species, yet little monitoring or research has focused on wildlife response to shearing. The goal of this research was to formally evaluate the effect of shrub and sapling shearing as a best management strategy for Golden‐winged Warbler (Vermivora chrysoptera) conservation at a regional scale. Specifically, we surveyed for male Golden‐winged Warblers during the breeding season in sheared sites and untreated reference sites across portions of the western Great Lakes to assess the effects of (1) management status (i.e., sheared aspen or alder vs. untreated sites) and (2) patch‐level vegetation characteristics on male abundance. We found that male Golden‐winged Warbler abundance was twice as high in sheared sites than in mature reference sites and peaked when sapling cover was ~40%. Male abundance was also negatively associated with percent cover of forbs and nonvegetated ground. These findings highlight the importance of patch‐level heterogeneity when implementing shearing treatments for Golden‐winged Warblers and demonstrate the potential need for pretreatment site assessments to help focus conservation efforts for this species. Ultimately, our results support the use of a site‐specific, nuanced approach to shearing implementation to maximize cost efficiency and desired species outcomes.
Wind and small mammals are complementary fungal dispersers
Authors: Borgmann‐Winter Benjamin W. , Stephens Ryan B. , Anthony Mark A. , Frey Serita D. , D'Amato Anthony W. , Rowe Rebecca J. 
Published: March 2023

AbstractFollowing a disturbance, dispersal shapes community composition as well as ecosystem structure and function. For fungi, dispersal is often wind or mammal facilitated, but it is unclear whether these pathways are complementary or redundant in the taxa they disperse and the ecosystem functions they provide. Here, we compare the diversity and morphology of fungi dispersed by wind and three rodent species in recently harvested forests using a combination of microscopy and Illumina sequencing. We demonstrate that fungal communities dispersed by wind and small mammals differ in richness and composition. Most wind‐dispersed fungi are wood saprotrophs, litter saprotrophs, and plant pathogens, whereas fungi dispersed in mammal scat are primarily mycorrhizal, soil saprotrophs, and unspecified saprotrophs. We note substantial dispersal of truffles and agaricoid mushrooms by small mammals, and dispersal of agaricoid mushrooms, crusts, and polypores by wind. In addition, we find mammal‐dispersed spores are larger than wind‐dispersed spores. Our findings suggest that wind‐ and small‐mammal‐facilitated dispersal are complementary processes and highlight the role of small mammals in dispersing mycorrhizal fungi, particularly following disturbances such as timber harvest.
Cobalt‐Promoted Transfer Hydrogenation of Azaaryl Ketones by Using Formate as the Hydrogen Source
Authors: Yu Rurong , Zhang Xinyu , Hao Feiyue , Jin Zhengneng , Liu Guyue , Dai Guoliang , Wu Jiashou 
Published: March 2023

AbstractA novel cobalt‐catalyzed reduction of 2‐pyridyl ketones and related heteroaryl compounds using formate as reductant was developed. Ketone substrate is activated by chelation with cobalt, which makes the present method highly selective. A possible reaction mechanism is proposed.
Application of the International League Against Epilepsy Neonatal Seizure Framework to an international panel of medical personnel
Authors: Yozawitz Elissa G. , Cilio Maria R. , Mizrahi Eli M. , Moon Jee‐Young , Moshé Solomon L. , Nunes Magda L. , Plouin Perrine , Vanhatalo Sampsa , Zuberi Sameer , Pressler Ronit M. 
Published: March 2023

AbstractObjectiveThe International League Against Epilepsy (ILAE) Neonatal Seizure Framework was tested by medical personnel.MethodsAttendees at the 2016 ILAE European Congress on Epileptology in Prague, the International Video‐EEG Course in Pediatric Epilepsies in Madrid 2017, and a local meeting in Utrecht 2018, were introduced to the proposed ILAE neonatal classification system with teaching videos covering the seven types of clinical seizures in the proposed neonatal classification system. Five test digital video recordings of electroencephalography (EEG)‐confirmed motor neonatal seizures were then shown and classified by the rater based on their knowledge of the proposed ILAE Neonatal Seizure Framework. A multi‐rater Kappa statistic was used to assess the agreement between observers and the true diagnosis.ResultsThe responses of 194 raters were obtained. There was no single predominant classification system that was currently used by the raters. Using the ILAE framework, 78%–93% of raters correctly identified the clinical seizure type for each neonate; the overall inter‐rater agreement (Kappa statistic) was 0.67. The clonic motor seizure type was most frequently accurately identified (93% of the time; κ = 0.870). EEG technicians correctly identified all presented motor seizure types more frequently than any other group (accuracy = 0.9).SignificanceThe ILAE Neonatal Seizure Framework was judged by most raters to be better than other systems for the classification of clinical seizures. Among all seizure types presented, clonic seizures appeared to be the easiest to accurately identify. Average accuracy across the five seizure types was 84.5%. These data suggest that the ILAE neonatal seizure classification may be used by all healthcare professionals to correctly identify the predominant clinical seizure type.
Modeling human cancer predisposition syndromes using CRISPR/Cas9 in human cell line models
Authors: Draper Garrett M. , Panken Daniel J. , Largaespada David A. 
Published: March 2023

AbstractThe advancement of CRISPR mediated gene engineering provides an opportunity to improve upon preclinical human cell line models of cancer predisposing syndromes. This review focuses on using CRISPR/Cas9 genome editing tools to model various human cancer predisposition syndromes. We examine the genetic mutations associated with neurofibromatosis type 1, Li‐Fraumeni syndrome, Gorlin syndrome, BRCA mutant breast and ovarian cancers, and APC mutant cancers. Furthermore, we discuss the possibilities of using next‐generation CRISPR‐derived precision gene editing tools to introduce a variety of genetic lesions into human cell lines. The goal is to improve the quality of preclinical models surrounding these cancer predisposition syndromes through dissecting the effects of these mutations on the development of cancer and to provide new insights into the underlying mechanisms of these cancer predisposition syndromes. These studies demonstrate the continued utility and improvement of CRISPR/Cas9‐induced human cell line models in studying the genetic basis of cancer.
Vascular endothelial growth factor promotes transdifferentiation of astrocytes into neurons via activation of the MAPK/Erk‐Pax6 signal pathway
Authors: Lei Yu , Chen Xiao , Mo Jia‐Lin , Lv Ling‐Ling , Kou Zeng‐Wei , Sun Feng‐Yan 
Published: March 2023

AbstractReactive astrocytes can be transformed into new neurons. Vascular endothelial growth factor (VEGF) promotes the transformation of reactive astrocytes into neurons in ischemic brain. Therefore, in this study, the molecular mechanism of VEGF's effect on ischemia/hypoxia‐induced astrocyte to neuron transformation was investigated in the models of rat middle cerebral artery occlusion (MCAO) and in astrocyte culture with oxygen and glucose deprivation (OGD). We found that VEGF enhanced ischemia‐induced Pax6, a neurogenic fate determinant, expression and Erk phosphorylation in reactive astrocytes and reduced infarct volume of rat brain at 3 days after MCAO, which effects could be blocked by administration of U0126, a MAPK/Erk inhibitor. In cultured astrocytes, VEGF also enhanced OGD‐induced Erk phosphorylation and Pax6 expression, which was blocked by U0126, but not wortmannin, a PI3K/Akt inhibitor, or SB203580, a MAPK/p38 inhibitor, suggesting VEGF enhanced Pax6 expression via activation of MAPK/Erk pathway. OGD induced the increase of miR365 and VEGF inhibited the increase of OGD‐induced miR365 expression. However, miR365 agonists blocked VEGF‐enhanced Pax6 expression in hypoxic astrocytes, but did not block VEGF‐enhanced Erk phosphorylation. We further found that VEGF promoted OGD‐induced astrocyte‐converted to neuron. Interestingly, both U0126 and Pax6 RNAi significantly reduced enhancement of VEGF on astrocytes‐to‐neurons transformation, as indicated Dcx and MAP2 immunopositive signals in reactive astrocytes. Moreover, those transformed neurons become mature and functional. We concluded that VEGF enhanced astrocytic neurogenesis via the MAPK/Erk‐miR‐365‐Pax6 signal axis. The results also indicated that astrocytes play important roles in the reconstruction of neurovascular units in brain after stroke.
Supramolecular Behaviour of N,N′‐Bridged Guanidinium Nitrates in the Crystalline State: Identification of Privileged Hydrogen Bond Networks
Authors: Wüstenberg Reinhold Gregor , Neudörfl Jörg‐Martin , Schmalz Hans‐Günther 
Published: March 2023

AbstractUsing the marine natural product ptilocaulin as a starting point, the supramolecular behavior of N,N′‐bridged guanidinium nitrates in the crystalline state was investigated. For this purpose, various N,N′‐bridged guanidines were synthesized (typically by condensation of a 1,2‐ or 1,3‐diamine with cyanogen bromide) and subsequently converted into their nitrate salts with nitric acid. The crystal structures of 28 samples were determined by single crystal X‐ray crystallography and revealed the existence of a few privileged, recurring supramolecular motifs (hydrogen bond networks) formed by charge‐assisted self‐assembly. A topological analysis of possible pseudo‐2D‐patterns derived from the 1 : 1 ion pairs (generated by salt bridge formation between a N,N′‐bridged guanidinium cation and a nitrate anion) through additional H‐bonding uncovered only five conceivable regular structural motifs: (1) a linear chain, (2) an alternating (zig‐zag) chain, (3) a double chain, (4) a tape/ribbon‐type structure, and (5) a cyclotrimer. Experimentally, only the first four of these motives were observed while the cyclotrimer, as a non‐infinite and therefore particular super‐structure, did not occur. Other H‐bonding patterns were found (in three cases) when water was incorporated in the crystals. In two cases, polymorphism was observed. The identified supramolecular preferences prove the value of N,N′‐bridged guanidines as useful and easily tunable building blocks for supramolecular chemistry and crystal engineering.
Phase stability, fuel properties, and diesel engine performance of palm‐oil‐based microemulsion biofuels
Authors: Attaphong Chodchanok , Morawan Nattaya , Sarikprueck Piampoom , Charoensaeng Ampira , Khaodhiar Sutha 
Published: March 2023

AbstractMicroemulsification and blending are two viscosity‐modifying techniques of vegetable oils for direct use with diesel engine. In this study, alcohol blends are mixtures of ethanol, diesel, and palm‐oil biodiesel while microemulsion biofuels are thermodynamically stable, clear, and single‐phase mixtures of diesel, palm oil, and ethanol stabilized by surfactants and cosurfactants. Although there are many studies on biofuels lately, there is limited research on using biodiesel as a surfactant in microemulsion formulations and applied on engine performance at different engine loads. Therefore, the objectives are to investigate phase stability and fuel properties of formulated biofuels (various blends and microemulsions), to determine the engine performance at different engine loads (no load, and from 0.5 to 2.0 kW), and to estimate laboratory‐scale cost of the selected biofuels compared to diesel and biodiesel. The results showed that phase stability and fuel properties of selected microemulsion biofuels are comparable to diesel and biodiesel. These microemulsion biofuels can be applied to the diesel engine at different loads while diesel‐ethanol blends and palm‐oil‐biodiesel‐ethanol blends cannot be. It was found that the energy efficiencies of the system using microemulsion biofuels were slightly lower than the average energy efficiency of diesel engine. From this study, it can be summarized that microemulsion biofuels can be formulated using palm‐oil biodiesel (palm‐oil methyl ester) as a bio‐based surfactant and they can be considered as environmentally‐friendly alternatives to diesel and biodiesel. However, cost considerations showed that the raw materials should be locally available to reduce additional costs of microemulsion biofuels.
Cocoa powder and fermented jackfruit seed flour: A comparative cell‐based study on their potential antioxidant and anti‐inflammatory activities after simulated gastrointestinal digestion
Authors: Spada Fernanda Papa , Lazarini Josy Goldoni , Batista Pollyanna Souza , de Oliveira Sartori Alan Giovanini , Saliba Ana Sofia Martelli Chaib , Pedroso Gomes do Amaral José Eduardo , Purgatto Eduardo , de Alencar Severino Matias 
Published: March 2023

AbstractBACKGROUNDJackfruit seed flour can be used as a cocoa aroma replacer with similar technological properties. The purpose of this study was to investigate the in vivo toxicity and in vitro antioxidant activity of fermented jackfruit seed flour (Fjs) and non‐alkaline cocoa powder (Nac).RESULTSFjs and Nac extracts (Fjs‐E and Nac‐E) were produced and submitted to in vitro gastrointestinal digestion producing digested fractions named Fjs‐D and Nac‐D, respectively. Nac‐E showed over two‐fold higher oxygen radical absorbance capacity (ORAC) than Fjs‐E. However, after simulated gastrointestinal digestion (in vitro), there were no significant differences between Nac‐D and Fjs‐D (P < 0.01). Similarly, the cellular antioxidant activity (CAA) of Nac‐D and Fjs‐D was not significantly different (P < 0.01). The anti‐inflammatory assay in transgenic RAW 264.7 murine macrophages showed that Fjs‐E did not affect cell viability up to 300 μg mL−1 (P > 0.05) and reduced by 15% the release of TNF‐α (P < 0.05). Fjs‐D did not affect cell viability up to 300 μg mL−1 (P > 0.05) and showed 58% reduction of NF‐κB activation (P < 0.05), with no effects on TNF‐α levels. Treatment with Nac‐E up to 300 μg mL−1 did not decrease cell viability (P > 0.05) and reduced the release of TNF‐α levels by 34% and 66% at 100 and 300 μg mL−1, respectively (P < 0.05). Nac‐D did not reduce the NF‐κB activation or TNF‐α levels at any tested concentration.CONCLUSIONCollectively, these findings indicate that Fjs is a safe and promising functional ingredient with biological activities even after gastrointestinal digestion. © 2023 Society of Chemical Industry.
I, chatbot! the impact of anthropomorphism and gaze direction on willingness to disclose personal information and behavioral intentions
Authors: Pizzi Gabriele , Vannucci Virginia , Mazzoli Valentina , Donvito Raffaele 
Published: March 2023

AbstractThe present research focuses on the interplay between two common features of the customer service chatbot experience: gaze direction and anthropomorphism. Although the dominant approach in marketing theory and practice is to make chatbots as human‐like as possible, the current study, built on the humanness‐value‐loyalty model, addresses the chain of effects through which chatbots' nonverbal behaviors affect customers' willingness to disclose personal information and purchase intentions. By means of two experiments that adopt a real chatbot in a simulated shopping environment (i.e., car rental and travel insurance), the present work allows us to understand how to reduce individuals' tendency to see conversational agents as less knowledgeable and empathetic compared with humans. The results show that warmth perceptions are affected by gaze direction, whereas competence perceptions are affected by anthropomorphism. Warmth and competence perceptions are found to be key drivers of consumers’ skepticism toward the chatbot, which, in turn, affects consumers’ trust toward the service provider hosting the chatbot, ultimately leading consumers to be more willing to disclose their personal information and to repatronize the e‐tailer in the future. Building on the Theory of Mind, our results show that perceiving competence from a chatbot makes individuals less skeptical as long as they feel they are good at detecting others’ ultimate intentions.