bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Maxillary and Mandibular Frenal Attachment and Its Association with Age, Gender and Oral Hygiene Status in Nepalese Population Seeking Dental Treatment
Authors: Rijal Arjun Hari , Humagain Manoj , Lamichhane Simant , Ghimire Pratistha , Thapa Sachita 
Published: August 2023

Abstract

Background: Frenum attachments are folds of mucous membrane that connect the lips to the alveolar mucosa and underlying periosteum. Aberrant positioning of the maxillary and mandibular labial frenum can lead to various clinical issues, including mucogingival problems and midline diastema. The objective of this study was to assess the prevalence of maxillary and mandibular frenal attachments and their association with age, gender, and oral hygiene status in the Nepalese population seeking dental treatment.
Methods: This descriptive cross-sectional study was conducted over a period of 6 months, from February 2022 to July 2023, among patients visiting the Department of Periodontology and Oral Implantology, aged 6 years and above, after obtaining official permission from the institutional review committee (IRC-KUSMS Approval No. 8/23). The study collected data on morphological variations of frenal attachment and various periodontal parameters such as Oral Hygiene Index Simplified (OHI-S), pocket depth, recession, and midline diastema in both arches. Descriptive statistics, including frequency and percentage, were used to analyze the data. The Chi-square test was employed to determine the correlation between gender and types of frenulum attachment, while Analysis of Variance (ANOVA) was used to assess the association of frenal attachments with oral hygiene status.
Results: Among 380 patients, the prevalence of frenal attachment was as follows: gingival 248 (65.30%), mucosal 71 (18.70%), papillary 42 (11.10%), and papillary penetrating 19 (5.00%) in the maxilla, and mucosal 225 (59.20%) and gingival 155 (40.78%) in the mandible. Among the different morphological variations of frenal attachments, normal frenum was the most common, accounting for 231 cases (60.80%), followed by frenum with a nodule, with 101 cases (26.60%).
Conclusions: The study found significant associations between frenal attachment and gender, as well as oral hygiene status. The prevalence of frenal attachments in this study was comparable to findings from previous research.
The Effects of Expansions in Hospitals on the Applicability ofPerformance Certificate Programme
Authors: Kaymakamzade Bilgen , Savaşan Ahmet , Kara Beyhan , Tulbentci Tugsad , Amilo David 
Published: August 2023

Abstract
This study examines how the implementation of the Leadership in Energy and Environmental Design (LEED)certification system has affected healthcare services in private hospitals in North Cyprus. The Near EastUniversity (NEU) hospital achieved Gold-level recognition with a minimum score of 79 points, while Dr.Burhan Nalbanto ̆glu Hospital (BNH) received 31 points. Through sensitivity analysis of indoor air qualityand sustainable land criteria, it becomes evident that hospitals adopting LEED certification systems offerhigher-quality services and present distinct advantages. The findings suggest that aligning government hos-pitals with green certification criteria may contribute to improved patient outcomes. Furthermore, datacollected from government hospitals and the Near East Hospital support a positive relationship betweengreen hospital criteria and enhanced patient and employee satisfaction. Statistical analysis reveals signifi-cant evidence (p < 0.05) that distinguishes hospitals meeting the green hospital certification criteria fromthose that do not. The study also examined the effects of hospital expansions on the applicability of per-formance certificate programs and the management of COVID-19. Various criteria, including LEED points,sustainable sites, regional priorities, water efficiency, design innovation, materials and resources, and indoorenvironmental quality, are analyzed using data from two hospitals, YD ̈U and BNH, to assess changes inthese criteria before and after the expansions. The results provide valuable insights for decision-makers andhealthcare administrators seeking to enhance hospital infrastructure and operations to meet certificationstandards and ensure effective pandemic management. This study highlights the importance of adoptinggreen certification criteria in hospital infrastructure and management to enhance patient outcomes, employeesatisfaction, and overall service quality.
Rhinocerebral Mucormycosis and Trichosporon asahii Fungemia in a patient with acute lymphoblastic leukemia: A rare co-infection and literature review
Authors: Hu Liuyang , Liu Guiliang , Wang Xiuri , Chen Xingchun 
Published: August 2023

Abstract
Background
We report one rare case of concomitant rhinocerebral mucormycosis and Trichosporon asahii (T. asahi) Fungemia secondary to Pseudomonas aeruginosa bloodstream infection(BSI) in a neutropenic patient with acute lymphoblastic leukemia. A review of the literature is included.
Case presentation:
A 1-year-old baby was diagnosed with B-line acute lymphoblastic leukemia and received regular chemotherapy which was admitted to hospital for vomiting, diarrhea, low fever and poor mental reaction. Carbapenem resistant- Pseudomonas aeruginosa was isolated via blood culture, and ceftazidime/ averbactam was administrated. The patient presented with necrotizing lesion on the right side of the nasal alar and the right corner of the eye. Later, necrosis rapidly expanded to almost his entire face on the 8th day, Rhizopus delemar and T. asahi was isolated from necrotic tissue. T. asahi was further recovered via blood culture. The anti-infection protocol was changed to treatment of Pseudomonas aeruginosa BSI with ceftazidime/ averbactam, amphotericin B cholesterol sulfate and voriconazole was administrated for Rhizopus delemar and T. asahi. Unfortunately, He deteriorated and died for multiple organ failure and rapid progress of infection.
Conclusions
For acute lymphoblastic leukemia patients, by maintaining a high level of clinical suspicion, promptly starting antifungal treatment, aggressively removing necrotic tissue through surgery, and addressing the underlying immunosuppression, it may be possible to decrease mortality rates.
Suppurative thyroiditis: Coinfection by Nocardia spp. and Mycobacterium Tuberculosis in an immunocompromised patient
Authors: Rueda Jhon Edwar Garcia , Naranjo Andrés David Monsalve , Benítez Carolina Giraldo , Quintero Juan David Ramírez 
Published: August 2023

Abstract

Suppurative thyroiditis (ST) is a rare entity with an incidence of 0.1–0.7% of thyroid diseases. The resistance to infection of the thyroid gland is explained by its encapsulated position, high blood flow, bactericidal action of iodine and extensive lymphatic network. Clinically, ST manifests with pain, fever, erythema, and dysphonia, usually with preserved thyroid function. Fine-needle aspiration is preferred for diagnosis because it not only allows microbiological sampling, but also therapeutic drainage and differentiation with subacute thyroiditis in cases of thyrotoxic. Regarding its etiology, it is most caused by Gram-positive bacteria, mainly Streptococcus and Staphylococcus. Among the Gram-negative, Salmonella is the most isolated. Regarding opportunistic microorganisms, Mycobacterium tuberculosis has a prevalence between 9.3–16%, while Nocardia represents 4%. Nocardia can spread hematogenously to any organ with tropism to the central nervous system and infrequently to the thyroid. It is characterized by abscess formation and chronic progression with relapses despite adequate treatment. Diagnosis requires clinical suspicion and microbiological isolation with an incubation time of up to 14 days, imaging studies are nonspecific and may show abscesses, thyroid scintigraphy is usually abnormal, with evidence of cold nodules. Infections in the thyroid gland are infrequent due to Mycobacterium tuberculosis even in areas where it is endemic; it presents a frequency of 0.1–0.4% of all cases of tuberculosis with a varied range of presentation as solitary nodule, diffuse or multinodular goiter. We present the first report in the literature of an immunocompromised patient with suppurative thyroiditis in coinfection by Nocardia and Mycobacterium tuberculosis.
Validation of key Arctic energy and water budget components in CMIP6
Authors: Winkelbauer Susanna , Mayer Michael , Haimberger Leopold 
Published: August 2023

Abstract

We investigate historical simulations of relevant components of the Arctic energy and water budgets for 39 Coupled Model Intercomparison Project Phase 6 (CMIP6) models and validate them against observation-based estimates. We look at simulated seasonal cycles, long-term averages and trends of lateral transports and storage rates in atmosphere and ocean as well as vertical fluxes attop-of-atmosphere and the surface. We find large inter-model spreads and systematic biases in the representation of annual cycles andlong-term averages. Surface freshwater fluxes associated with precipitation and evaporation as well as runoff from Arctic lands tend to be overestimated by most CMIP6 models and about two thirds of the analysed models feature an early timing bias of one month in the runoff cycle phase, related to an early snow melt bias and the lack of realistic river routing schemes. Further, large biases are found for oceanic volume transports, partly because data required for accurate oceanic transport computations has not been archived. Biases are also present in the simulated energy budget components. The net vertical energy flux at the Arctic surface as well as poleward oceanic heat transports are systematically underestimated by all models. We find strong anti-correlation between average oceanic heat transports and mean sea ice cover, atmospheric heat transports, and also the long-term ocean warming rate. The latter strongly suggests that accurate depiction of the mean state is a prerequisite for realistic projections of future warming of the Arctic. Our diagnostics also provide useful process-based metrics for model selection to constrain projections.
Impact resistance of Macro and Micro steel fibre reinforced Self- Compacted Concrete (SFRSCC) with modelling and reliability analysis
Authors: R Kesavamoorthi , G Mohan Ganesh 
Published: August 2023

Abstract
Adding steel fibres can transform the brittle characteristic of concrete into a ductile state. The objective of the current study is to test the impact resistance of macro and micro steel fibre-reinforced self-compacting concrete (SFRSCC) experimentally by applying a simulated drop-weight impact, as well as statistically and through reliability studies. Cube specimens were used for the experiment. The inclusion of macro and micro steel fibre (SF) greatly increased the concrete mixture’s impact resistance. All the concrete samples exhibited the same failure pattern. Using Response Surface Methodology (RSM), the impact resistance of SFRSCC mixtures can be accurately predicted. The first and failure cracks (N1 and N2) follow a two-parameter Weibull distribution (WD) function of drop-weight impact test.
Numerical conformal mapping for underground tunnels with arbitrary shapes based on Symm’s method
Authors: Chengzhang Jianing , Cheng Jun , Jiang Quan 
Published: August 2023

Abstract
Conformal mapping technique is important in theoretical analysis and numerical computation for the fields of stress and displacement, since that these computations for tunnels with arbitrary shapes are always based on it. In general, a tunnel with arbitrary shape has no analytical solution for conformal mapping. Therefore, the study of numerical method for the conformal mapping has great significance. The basic functions of numerical conformal mapping are given based on Symm’s method. Furthermore, the inverse mapping functions were deduced firstly according to the relationships between the boundary nodes in physical and mapped plane. Compared to the other numerical methods, the presented method has some advantages such that, it is simple in concept to be understood, and can give the mapping function without iteration process. The method can be used to the numerical forward and inverse conformal mappings for multiple underground tunnels with arbitrary shapes in finite and infinite domains. With the help of method of fundamental solutions, the interpolation equations were proposed for multiple underground tunnels with arbitrary shapes. Finally, several numerical examples for the groups of U-shaped and rectangle tunnels have been given to verify the effectiveness of this method. The numerical results can convergent to real cases, which show that the proposed method has the properties of high accuracy and strong adaptability.
Admissibility and event-triggered dissipative observer-based stabilization of discrete-time T-S fuzzy singular systems via fuzzy Lyapunov functions
Authors: Nguyen Ngoc Hoai An , Kim Sung Hyun 
Published: August 2023

Abstract

This paper presents a new method to design an event-triggered dissipative observer-based control for discrete-time Takagi-Sugeno fuzzy singular systems by handling admissibility, dissipativity, observer-based control, and event-triggered data problems all in one. In particular, the proposed method has the advantage of being able to realize a one-step design framework that simultaneously designs both fuzzy observer and controller gains without using any iterative search algorithms. Furthermore, the proposed method provides the flexibility to set the fuzzy event weighting matrix in conjunction with other variables and supports the performance improvement of control systems by using a fuzzy Lyapunov function. Not only that, different from other eventtriggered output-feedback control techniques, the event generation function of this paper is constructed based on actual system outputs rather than estimated states so that estimation errors are not reflected in the event-triggered mechanism. Finally, two illustrative examples are given to verify the effectiveness of the proposed method.
Numerical simulation of a coupled GMAW process model
Authors: Weigelt Felix , Trautmann Marcus , Ungethüm Tim , Manzke Sebastian , Schmale Hans Christian , Füssel Uwe 
Published: August 2023

Abstract
With the help of numerical simulations of welding processes, precise predictions can be made and, if necessary, elaborate test series for the production of complex components can be reduced. Since the interactions between the arc and the workpiece surface play a central role, a coupled consideration of these sub-areas leads to a reduction of the assumptions on the model side. Therefore, a coupled GMAW process model has been developed, which consists of the partial models of the arc (finite volume method) and the weld pool (smoothed particle hydrodynamics method), and by combining them with a suitable coupling algorithm, the mutual dependence is taken into account. In this paper, the development of the coupled model will be presented. This contribution is funded within the DFG project FU 307/18-1. First, welding tests were carried out to determine boundary conditions and validation parameters. With the help of these values, a further developed, three-dimensional GMAW arc model could be validated. Furthermore, a particle-based weld pool model was developed taking the material transition into account. These partial models were coupled on the side of the arc by varying the distribution of the heat flux density, the arc pressure and the shear stress, and on the side of the weld pool by changing the surface topology of the workpiece. By comparing the dimensions of the melt zones, it was finally possible to verify the overall model and  determine its high validity.
Characterization of a novel endornavirus isolated from the phytopathogenic fungus Rhizoctonia solani
Authors: Li Yangyi , Huang Xingxue , Zhou Guolin , Ye Anhua , Deng Yaohua , Shi Lingfang , Zhang Runhua 
Published: August 2023

Abstract
Rhizoctonia solani endornavirus 8 (RsEV8) was isolated from strain XY175 of Rhizoctonia solani. The full-length genome of RsEV8 is 16147 nucleotides (nt) in length and contains a single open reading frame that encodes a large polyprotein of 5227 amino acid. The polyprotein contains four conserved daomains including viral methyltransferase, putative DEAH box helicase, Viral helicase and RNA-dependent RNA polymerase (RdRp). RsEV8 has a shorter 3' leader (58 nt) and a longer 5' trailer (404 nt) sequences. A multiple sequence alignment indicated that the RdRp of RsEV8 has eight typical RdRp motifs. According to the BLASTp result of the nucleotide sequence, RsEV8 shares 39.31% identity to Rhizoctonia cerealis endornavirus-1084-7. Phylogenetic analysis demonstrated that RsEV8 clustered with members of the genus Betaendornavirus.
Establishment and evaluation of a nomogram prediction model for the risk of vascular calcification in stage 5 chronic kidney disease patients
Authors: Yang Yan , Gong Wenyu , Li Shishi , Chen Sining , Yang Zhiqian , Kuang Chaoying , Zhong Yuzhen , Liu Fanna 
Published: August 2023

Abstract

Vascular calcification (VC) is a common complication of chronic kidney disease (CKD) that has a detrimental effect on patients' survival and prognosis. The aim of this study was to develop and validate a practical and reliable prediction model for VC in CKD5 patients. The medical records of 544 CKD5 patients were reviewed retrospectively. Multivariate logistic regression analysis was used to identify the independent risk factors for vascular calcification in patients with CKD5 and then created a nomogram prediction model. The area under the receiver operating characteristic curve (AUC), Hosmer-Lemeshow test, and decision curve analysis (DCA) were used to assess model performance. The patients were split into groups with normal and high serum uric acid levels, and the factors influencing these levels were investigated.Age, BUN, SUA, P and TG were independent risk factors for vascular calcification in CKD5 patients in the modeling group (P< 0.05). In the internal validation, the results of model showed that the AUC was 0.917. No significant divergence between the predicted probability of the nomogram and the actual incidence rate (x2=5.406,P=0.753) was revealed by the calibration plot and HL test, thus confirming that the calibration was satisfactory. The external validation also showed good discrimination (AUC=0.973). The calibration chart and HL test also demonstrated good consistency. Besides, the correlation analysis of serum uric acid levels in all CKD5 patients revealed that elevated uric acid levels may be related to gender, BUN, P, and TG.
Virome analysis of Desmodus rotundus tissue samples from the Amazon region
Authors: Albuquerque Nádia K. , Silva Sandro P. , Aragão Carine F. , Cunha Tânia Cristina A. S. , Paiva Francisco A. S. , Coelho Taciana F. S. B. , Cruz Ana Cecília R. 
Published: August 2023

Abstract
Background: Bats are renowned for harboring a high viral diversity, their characteristics contribute to emerging infectious diseases. However, environmental and anthropic factors also play a significant role in the emergence of zoonotic viruses. Metagenomic is an important tool for investigating the virome of bats and discovering new viruses. Results: 24 families of virus were detected in lung samples by sequencing and bioinfomatic analysis, the largest amount of reads was focused on the Retroviridae and contigs assembled to Desmodus rotundus endogenous retrovirus, which was feasible to acquire complete sequences. The reads were also abundant for phages. Conclusion: Tissue samples provided a large amount of data and could serve as a basis for comparison for other studies that exclusively obtain results through blood or excreta. The identification and taxonomic categorization of viruses hosted by bats carry epidemiological significance due to the potential for viral adaptation to other animals and humans, which can have severe repercussions for public health. Furthermore, the characterization of endogenized viruses helps to understanding the host genome and the evolution of the species.
Synthetic return of the Meldrum’s acid. 2,2-dimethyl-1,3-dioxane- 4,6-dione assisted formation of tetrahydroquinolin-2-one derivatives. Short synthetic pathway to the biologically useful scaffold
Authors: Ryczkowska Małgorzata , Trocka Alicja , Hromova Anna , Makowiec Sławomir 
Published: August 2023

Abstract
A new method for the preparation of tetrahydroquinolin-2-one derivatives has been described. The two-step reaction between enaminone and acylating agent followed by electrophilic cyclization can be performed in a single synthesis procedure, without isolation of intermediates. The whole process is facilitated by the use of acyl Meldrum’s acids which not only shortens the preparation time of the substrates but also easily extends the range of substituents used. Method scope and limitation were verified on various combinations of reagents and revealed general applicability of the method to the synthesis of tetrahydroquinolin-2-one core. Some exceptions to the regular course of the reaction were observed when a strongly EDG was introduced via acyl Meldrum’s acids, and the mechanism of this process was elucidated during the investigation.
Lipopolysaccharide pretreatment increases the sensitivity of the TRPV1 channel and promotes an anti-inflammatory phenotype of capsaicin-activated macrophages
Authors: Vašek Daniel , Fikarová Natálie , Marková Vendula Nagy , Honc Ondřej , Pacáková Lenka , Porubská Bianka , Somova Veronika , Novotný Jiří , Melkes Barbora , Krulova Magdalena 
Published: August 2023

Abstract

Background: The transient receptor potential vanilloid 1 (TRPV1) is well-established in neuronal function, yet its role in immune reactions remains enigmatic. The conflicting data on its inflammatory role, suggesting both pro-inflammatory and anti-inflammatory effects upon TRPV1 stimulation in immune cells, adds complexity. To unravel TRPV1 immunomodulatory mechanisms, we investigated how the TRPV1 agonist capsaicin influences lipopolysaccharide (LPS)-induced pro-inflammatory macrophage phenotypes. Results: Changes in the surface molecules, cytokine production, and signaling cascades linked to the phenotype of M1 or M2 macrophages of the J774 macrophage cell line and bone marrow-derived macrophages, treated with capsaicin before or after the LPS-induced inflammatory reaction were determined. The functional capacity of macrophages was also assessed by infecting the stimulated macrophages with the intracellular parasiteLeishmania mexicana. Conclusion: Our findings reveal that TRPV1 activation yields distinct macrophage responses influenced by the inflammatory context. LPS pre-treatment followed by capsaicin activation prompted increased calcium influx, accompanied by a shift toward an anti-inflammatory M2b-like polarization state.