bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a continuing care program based on the long-term care insurance policy for stroke survivors: a quasi-experimental trial
Authors: Liu Zhu-Yun , Zhang Xiao-Pei , Wei Lin , Ye Ri-Chun , Hu Cai-Xia , Nie Dan , Wu Jiao-Yang 
Published: March 2023

Abstract
Background

There were 28.76 million stroke patients in China, with 3.94 million new strokes annually. Around 70% of survivors live with varying degrees of permanent disability, placing a heavy burden on families and society. Stroke patients have a complex and high need for continuing care services after discharge from the hospital. The study was to evaluate the effectiveness of the continuing care program on the activity of daily life, the degree of disability, stroke recurrence and readmission in patients with stroke, based on the long-term care insurance policy.

Methods

Eighty-eight stroke patients were recruited from February 2021 to January 2022. They were allocated to either intervention group (N = 44) or control group (N = 44) based on whether the long-term care insurance application was successful. The intervention consisted of discharge education, 3-month in-home care and remote counseling. The activity of daily life, disability, recurrence and readmission of patients were evaluated between the groups before the intervention, at 1, 2, 3 and 6 months after discharge.

Results

There were no statistically significant differences between the groups in clinical characteristics at baseline. We detected significant interaction effects between time and group (p < 0.001), indicating that the scores of two outcomes changed differently over time in intervention and control groups. It was found that the participants of the intervention group had a statistically significant improvement in activity of daily life and disability than the control group at baseline and follow-up periods. The decrease in readmission of the intervention group was statistically significant than in the control group (χ2 = 6.040, p = 0.014; χ2 = 7.216, p = 0.007) at 1 and 2 months after discharge, but no significant difference was found at 3 and 6 months after discharge. At follow-up, there was no significant difference between groups regarding stroke recurrence rates (p > 0.05).

Conclusions

This study demonstrates the positive effects of a continuing care program based on the long-term care insurance policy on activity of daily life and disability in people with stroke. The effectiveness and feasibility of this intervention program suggest that its application should be promoted to promote the care and rehabilitation of stroke patients.
Trail registration: The trail was not registered as a quasi-experimental trail.
Efficiency of Different Doses of Potassium on Yield of Rice Under Different Establishment Methods
Authors: Sigdel Adarsha , Karkee Suraj , Dhakal Suman , Maraseni Tek 
Published: March 2023

Abstract
Disproportionate use of fertilizer in various systems of rice establishment amidst poor knowledge of nutrient use and availability under different soil and environmental condition had added further challenges to rice production. Among the substantial loss of major macronutrients from the rice field, potassium stands after nitrogen. The traditional approach of applying potassium fertilizer only at the initial growth stages has confined their availability during the crucial stage of flowering and grain filling. However, the application of potassium fertilizer on a split basis, meaning applying them at multiple growth stages throughout the growing season, could increase the nutrient availability leading to uniform grain filling during the reproductive stage resulting in higher yields and reduced sterility. Thus to track down the impacts of potassium split application on patterns of growth and yield of rice, a field experiment was conducted by plying different establishment methods and the varied amount and methods of potassium application. The experiment was conducted in a split-plot design with four replication in the sub-tropical climate of the inner terai of Nepal. The main plot treatment consisted of two establishment methods namely, direct seed rice (DSR) and transplanted rice (TPR) while sub-plot treatment consisted of seven potassium management practices i.e. potassium omission, 30kg K ha− 1 basal dose, 30kg K ha− 1 with two splits (15 kg K ha− 1as basal and 15 kg K ha− 1 at PI stage), 60kg K ha− 1 basal, 60kg K ha− 1 with two splits(30 kg K ha− 1as basal and 30 kg K ha− 1 at PI stage), 90kg K ha− 1 basal and 90kg K ha− 1 with two splits(45 kg K ha− 1as basal and 45 kg K ha− 1 at PI stage). The research revealed that grain yield was not significantly influenced by establishment methods but the straw yield was significantly influenced. Comparatively high grain yield was obtained in TPR (3.88 t ha− 1) compared to DSR (3.73 t ha− 1). Potassium applied at 60kg K ha− 1 with two splits resulted in a significantly higher (P < 0.05) yield (4.21t ha− 1). The overall analysis revealed that potassium applied at 60kg K ha− 1 and 90kg K ha− 1 with two splits under TPR resulted in high grain yield. The findings suggest that rice yield could be obtained through an efficient supply of potassium in splits at different crucial growth stages reducing sterility and enhancing rice growth.
Influence of Foveal Avascular Zone on Postoperative Visual Acuity in Macular Hole Surgery
Authors: An Hongbang , Wang Shu’na , Yu Wenxuan , Gao Meng , Li Lihua , Hao Fengqin , Liang Bing , Yongliang Cao 
Published: March 2023

Abstract
Background: To investigate the correlation between the pre- and post-operative foveal avascular zone (FAZ) area and visual acuity in patients with idiopathic macular hole (IMH).
Methods: Optical coherence tomography angiography (OCTA) was used to measure the values of the pre- and post-operative FAZ in IMH patients, and all patients were followed up for at least 3 months with changes in visual acuity recorded.
Results: A total of 30 IMH patients were included, 13 males and 17 females. All patients showed varying degrees of improvement in visual acuity after surgery. The correlation analysis results showed that the preoperative superficial, deep, and full-thickness FAZ were closely related to the best-corrected visual acuity at 3 months after surgery (r=0.521, 0.605, and 0.704, P＜0.05, ＜0.01, and ＜0.01), with the deep and full-thickness FAZ showing a more significant correlation than the superficial FAZ. At 1 week after surgery, the superficial, deep, and full-thickness FAZ showed significant differences compared to the preoperative values (t=4.8, P＜0.01, t=7.1, P＜0.01, and t=4.4, P＜0.01). At 1 month after surgery, the superficial, deep, and full-thickness FAZ showed significant differences compared to each layer's FAZ at 1 week after surgery (t=-2.1, P=0.046, t=-2.9, P＜0.01, and t=-4.1, P＜0.01).
Conclusion: There is a correlation between preoperative FAZ and postoperative visual acuity in IMH patients, with smaller preoperative FAZ associated with better postoperative visual acuity recovery.
Different genetic landscapes of papillary thyroid carcinoma and paired benign nodules revealed by integrated multi-omics analysis
Authors: yuan lijuan , yang ping , chen songhao , wei GANG , lu jianguo , hu xi'e , yang lin , he xianli , bao guoqiang 
Published: March 2023

Abstract
Background: Alterations in the genetic landscape of papillary thyroid carcinoma (PTC) compared with coincidental benign thyroid nodules, especially adenomatoid nodules, remain to be demonstrated.
Methods: Multi-omics profiling of whole-exome sequencing, assay for transposase-accessible chromatin using sequencing (ATAC-seq), and transcriptome sequencing were used for analysis.
Results: Chromatin accessibility in the PTC was lower than that in the benign nodules around the transcription start sites (distance <1 kb) with high interpatient heterogeneity of chromatin profiles and distinct open chromatin accessibility. The gene regions around the mutation loci that were only detected in PTC exhibited altered chromatin accessibility between the PTC and benign nodules. Through integrated ATAC-Seq and RNA-Seq analysis, ARHGEF28 and ARHGEF24, genes not previously related to PTC or adenomatoid nodules, were identified. They were overexpressed and hyperaccessible in adenomatoid nodules compared to those in PTC. They were regulated by TEAD4, and hyperaccessible binding sites were enriched in differentially accessible regions in benign nodules. In addition, extrachromosomal circular DNA (eccDNA) analysis derived from ATAC-sequencing showed indolent character, but no PTC-diver genes in the eccDNA was found.
Conclusions: This compendium of multi-omics data provides valuable insights and a resource for understanding the landscape of open chromatin features and regulatory networks in PTC and benign nodule pathogeneses.
Characterizing Microcracks in Carbonate Rock Subsurfaces in Tunisia Using Ultrasonic Velocity Variations
Authors: Abdelhedi Mohamed , Abbes Chedly 
Published: March 2023

Abstract
The recent, catastrophic earthquake that struck Turkey and surrounding regions in February 2023 has emphasized the need for an accurate and efficient method for identifying subsurface microfractures. These cracks, which are not visible to the naked eye, pose a significant threat to human safety. To tackle this issue, this study explores the use of ultrasonic waves for detecting and characterizing microfractures in carbonate rock subsurfaces in Tunisia.
The study involves collecting carbonate rock samples from subsurface formations in Tunisia and analyzing their ultrasonic wave velocity and velocity variations under uniaxial compressive stress in the laboratory. Our results show that ultrasonic methods are a reliable and effective means of detecting microfractures in subsurface materials, even in comparison to other seismic methods.
These findings have significant implications for subsurface exploration and the protection of critical structures and highlight the potential of ultrasonic methods for characterizing microfractures in carbonate rock subsurfaces. This study underscores the importance of continued research in this area and highlights the urgency of developing effective methods for detecting subsurface cracks to ensure the safety of communities in seismically active regions.
Bank financing for private sector development in sub-Saharan Africa: Do resilience and spillover effects matter?
Authors: SIRY Abdoulaye , OUEDRAOGO Adama , OUEDRAOGO Idrissa M. 
Published: March 2023

Abstract
The purpose of this study is to highlight the effect of bank resilience and spatial spillover effects on bank financing for the private sector in sub-Saharan Africa. Spatial autocorrelation tests were first performed over the period 2011–2020, followed by parametric tests that allowed the selection of the random-effects Spatial Durbin Model (SDM) as the appropriate technique for estimating the model of bank financing for the private sector in 27 sub-Saharan African countries. The results show that the more resilient banks are, the more incentive they have to extend credit directly to the private sector in the long run. Moreover, endogenous spatial effects through bank lending and exogenous spatial effects through remittances, trade openness, external debt stocks, bank profitability, government spending, and inflation are found in the long run. This means, for example, that an average increase in remittances or trade openness in neighbouring countries stimulates bank credit to the private sector in a given country. Incentives for banks to finance the private sector in the region should focus on building bank resilience, increasing public spending, fighting corruption and inflation at the national level, and limiting external debt. These different policies’ effects must be weighed against the expected positive spillover effects of remittances, trade openness, external debt stocks, bank profitability, and public spending in neighbouring countries. The expected negative effects of inflation must also be taken into account. The study differs from previous studies as it includes spatial spillover effects beyond direct effects.
JEL classification : G21, R12, C33, Q56
Swift and exhaustive Omicron outbreak in China after sudden exit from ‘zero-COVID’ policy
Authors: Ke Ruian , Goldberg Emma , Lin Qianying , Romero-Severson Ethan 
Published: March 2023

Abstract
In late 2022, China transitioned from a strict ‘zero-COVID’ policy to rapidly abandoning nearly all interventions and data reporting. This raised great concern about the presumably-rapid but undisclosed spread of the SARS-CoV-2 Omicron variant in a very large population of very low pre-existing immunity. By modeling a combination of case count and survey data, we show that Omicron spread extremely rapidly, at a rate of 0.42/day (95% CrI: [0.35, 0.51]/day) after the full exit from zero-COVID on Dec. 7, 2022. Consequently, we estimate that the vast majority of the population (97% [95%, 99%]) was infected during December, with the nation-wide epidemic peaking on Dec. 23. Overall, our results highlight the extremely high transmissibility of the variant and the importance of proper design of intervention exit strategies to avoid large infection waves.
Whole-genome identification of GRAS family and their potential roles in high-temperature stress of lettuce
Authors: Chen Li , Qin Yong , Fan Shuangxi 
Published: March 2023

Abstract
Lettuce is one of the most popular leafy vegetables in the world, but it is prone to high-temperature stress in the cultivation process leading to bolting, which affects the yield. The plant-specific transcription factors, GRAS proteins, play an important role which regulates plant growth development and abiotic stress. However, there is no comprehensive study of the GRAS gene family in lettuce. In this study, the complete LsGRAS genome was identified its expression was analyzed. The results showed that the 59 LsGRAS genes were classified phylogenetically divided into 4 conserved subfamilies and distributed unevenly on 9 chromosomes, with 50% physically adjacent to at least one another and 100% localized on the nucleus. Chromosome localization and gene structure analysis suggested that duplication events and a large number presence of intronless genes might be the reason why the LsGRAS gene family expands massively. Combined with gene annotation and interaction network analysis, the expression pattern of the LsGRAS gene under high-temperature treatment was analyzed, revealing the potential different functions of the LsGRAS gene under high-temperature stress. In conclusion, this study provides valuable information and candidate genes for improving the ability of lettuce to tolerate high-temperature stress.
Constructing and validating a novel nomogram based on nutritional biomarkers to predict prognosis postresection intrahepatic cholangiocarcinoma cases
Authors: Yao Jiangqiao , Zhu Xuewen , Deng LiMing , Yu Haitao , He Bangjie , Zhang Baofu , Lin Zixia , Yang Jinhuan , Yu Zhengping , Jin Bin , Chen Gang , Bao Wenming 
Published: March 2023

AbstractBackground:The intent of this study is to construct a novel nomogram using the psoas muscle index (PMI) and prognostic nutritional indexes (PNI) to identify high-risk intrahepatic cholangiocarcinoma postresection cases.Methods:In total, 178 patients with intrahepatic cholangiocarcinoma after hepatectomy in multiple hospitals between August 2012 and October 2019 were enrolled. Kaplan–Meier analysis revealed the overall survival and recurrence-free survival. Univariate and multivariate Cox regression analyses were performed to screen for the risk factors for overall and recurrence-free survival. A nomogram was established to predict the prognoses of patients with intrahepatic cholangiocarcinoma.Results:A total of 178 patients with intrahepatic cholangiocarcinoma were included. The overall survival was worse for patients with low psoas muscle and prognostic nutritional indexes combined (P < 0.01). The psoas muscle index, prognostic nutritional index, lymph node metastasis, and tumor differentiation were used to establish the nomogram. The area under the receiver operating characteristic curve (AUC) for the nomogram’s 1-, 3-, and 5-years predicted survival was 0.721, 0.777, and 0.752, respectively. Similarly, we verified the model’s satisfactory applicability through recurrence-free survival (AUC = 0.690, 0.784, and 0.744). The dichloroacetate curves revealed that the overall and recurrence-free survival models had clinical benefits. In addition, the difference between the patients at high and low risk was significant (P < 0.001).Conclusion:Our nomogram, using the psoas muscle and prognostic nutritional indexes, can identify patients with intrahepatic cholangiocarcinoma with the highest risk of poor prognosis and helps to improve poor prognosis.
Unveiling the Impact of Climate Variability on Forest Fire Occurrence in Namibia: A Modelling Study
Authors: Nikodemus Andreas , Trubin Aleksei , Bernal Diana Carolina Huertas , Kapuka Alpo , Hájek Miroslav , Ndeinoma Albertina , Purwestri Ratna Chrismiari 
Published: March 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
SMARCA4-deficient undifferentiated tumor presenting with fever and polyarthralgia: A case report
Authors: Ma Ping-chuan , Cheng Ai -ping , Sun Ying-ying , Wang Li-Juan 
Published: March 2023

Abstract
Background: SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a rare tumor that is independent of lung cancer and is classified as undifferentiated carcinoma of epithelial tumors according to the 2021 WHO classification of thoracic tumors. Loss of BRG1 expression due to SMARCA2 and SMARCA4 gene defects is a possible pathogenic mechanism. The pathological features are mainly nest-like rhabdoid cells with necrosis. Currently, there is a lack of well-recognized and convincing regimens for the treatment of SMARCA4-UT. Because the lesions are mainly located in the mediastinum and lung, patients can present with thoracic-related symptoms. We report the case of a middle-aged male patient with SMARCA4-UT who was admitted to the hospital with polyarthralgia and fever and lacked typical thoracic-related symptoms. This may be the first case report of SMARCA4-UT with fever and polyarthralgia as the initial symptoms, and its diagnostic idea and case characteristics are worthy of consideration and reference.
Case Description: A 57-year-old male fisherman with a long history of smoking and emphysema was initially admitted to the Department of Rheumatology and Immunology because of fever and polyarthralgia as the initial symptoms. The imaging examination suggested a mediastinal mass. With the gradual advancement of the examination, the riddle of fever and polyarthralgia was gradually revealed. After symptom control with steroids, he underwent thoracoscopic surgery for mediastinal lymph node biopsy, and SMARCA4-UT was finally diagnosed. He was evaluated and transferred to the oncology department for one cycle of postoperative adjuvant chemotherapy, and he was discharged with good symptom control after discharge.We lost follow-ups of patients after they were discharged.
Conclusions: Although fever and multiple arthralgias are not uncommon in neoplastic lesions, as atypical initial symptoms of rare tumors, clinicians should be aware of this when diagnosing tumors and not limited to SMARCA4-UT. In addition, the pathological and imaging features of SMARCA4-UT should be fully understood.
Oblateness and mass variation effects on the Hill R4BP Abdullah
Authors: Ansari Abdullah , Sahdev Shiv Kumar , Alebraheem Jawdat , Kellil Rabah 
Published: March 2023

Abstract
The oblateness and mass variation effects are studied in the circular Hill restricted 4-body problem (R4BP). Here we assume two bodies as oblate in shape and third one as spherical in shape, these three bodies are at the vertices of a triangle. The 4th infinitesimal body varies its mass and moving under the perturbed gravitational forces in the plane of primaries. With these perturbations, we evaluate the equations of motion and quasi-jacobian integral using specific scales and transformations. Finally, the numerical presentations are given such as stationary points, regions of motion, surfaces of section, periodic orbits and basins of convergence.
2010 MSC: 00-01, 99-00
Nearby Fault Interaction within the Double-Vergence Suture in Eastern Taiwan during the 2022 Chihshang Earthquake Sequence
Authors: Tang Chi-Hsien , Lin Yunung , Tung Hsin , Wang Yu , Lee Shiann-Jong , Hsu Ya-Ju , Shyu J. Bruce H. , Kuo Yu-Ting , Chen Horng-Yue 
Published: March 2023

Abstract
Faults interact through stress changes induced by earthquakes and viscoelastic flow acting in the lithosphere, but the process can be geometry-dependent and temporally-variant. The Chihshang earthquake sequence in September 2022, eastern Taiwan offers an unprecedented opportunity to study the interaction of two head-to-head conjugate thrust faults in the earthquake cycle. By combining geodetic and geological observations, we map the coseismic slip on the Central Range fault and the dynamically-triggered shallow slip on the Longitudinal Valley fault, which has been creeping rapidly in the interseismic period. Overlapping regions of seismic and aseismic slip suggest that an individual segment of fault is capable of hosting a variety of distinct slip behaviors. Moreover, substantial stress decrease on one fault is imparted by the large earthquake on the other, resulting in seismic bursts in an out-of-phase pattern as seen in the hundred-year historical records. Such fault interaction implies the need for time-dependent seismic hazard reassessment for the complex fault system.
Invasion of Exotic Plants Species in rural-urban gradient in Jharkhand, India: Their Harmful Effects and Beneficial Uses
Authors: Mishra Shambhu Nath , Mukherjee Prasanjit , Kumar Rahul 
Published: March 2023

Abstract

Invasive plant species (IPS) are considered one of the major drivers of biodiversity loss, altering ecosystem services and socio-economic conditions through different mechanisms. However, the ecological impacts of IPS are well documented, while a few benefits of alien species were also observed. Decisions need to be made on whether benefits derived from the invasive spread of an alien species outweigh the reduced value of ecosystem services, e.g., the loss of grazing land. The present study was carried out in Gutwa village near the Ranchi Smart Cities, where the encroachment of invasive plants was in accelerated due to infrastructure and other anthropogenic activity. For the enumeration of invasive plant species (IPS) research site has been classified into three groups (1) G1 (infrastructure developed area); (2) G2 (developing; infrastructure is going on) and (3) G3 (undeveloped or natural vegetation dominant area). Field data has been collected from fifteen quadrats, each of 3m x3 m. Quantitative analysis has been done with standard methods. Statistically, the variance of all quadrats emphasizes the dispersions nature of alien species within the group of all quadrats. The opportunity for the accidental invasion of alien species may increase with rapid urbanization and globalization. Because of this, the present study attempted to the documentation of harmful and beneficial uses of the invasive alien plant species in the rural-urban gradient in Gutwa village. So, it is necessary to consider actions to deal with the current problems in Gutwa village in Ranchi caused by invasive species and to reduce the magnitude of the problem in the future. Management prospects can be further strengthened through their linkage with geospatial technologies (remote sensing and GIS) by mapping and monitoring the IPS spread.