bluuebunny/crossref_metadata_2025_split huggingface dataset:
Valence Oscillation of Ru Active Sites for Efficient and Robust Acidic Water Oxidation
Authors: Deng Liming , Hung Sung‐Fu , Lin Zih‐Yi , Zhang Ying , Zhang Chenchen , Hao Yixin , Liu Shuyi , Kuo Chun‐Han , Chen Han‐Yi , Peng Jian , Wang Jiazhao , Peng Shengjie 
Published: September 2023

AbstractThe continuous oxidation and leachability of active sites in Ru‐based catalysts hinder practical application in proton‐exchange membrane water electrolyzers (PEMWE). Herein, robust inter‐doped tungsten–ruthenium oxide heterostructures [(Ru–W)Ox] fabricated by sequential rapid oxidation and metal thermomigration processes are proposed to enhance the activity and stability of acidic oxygen evolution reaction (OER). The introduction of high‐valent W species induces the valence oscillation of the Ru sites during OER, facilitating the cyclic transition of the active metal oxidation states and maintaining the continuous operation of the active sites. The preferential oxidation of W species and electronic gain of Ru sites in the inter‐doped heterostructure significantly stabilize RuOx on WOx substrates beyond the Pourbaix stability limit of bare RuO2. Furthermore, the asymmetric Ru–O–W active units are generated around the heterostructure interface to adsorb the oxygen intermediates synergistically, enhancing the intrinsic OER activity. Consequently, the inter‐doped (Ru–W)Ox heterostructures not only demonstrate an overpotential of 170 mV at 10 mA cm−2 and excellent stability of 300 h in acidic electrolytes but also exhibit the potential for practical applications, as evidenced by the stable operation at 0.5 A cm−2 for 300 h in PEMWE.
Design of Blood Vessel Models using Magnetic‐Responsive Vascular Platforms
Authors: Manjua Ana C. , Cabral Joaquim M.S. , Ferreira Frederico Castelo , Gardeniers Han , Portugal Carla A.M. , Gumuscu Burcu 
Published: September 2023

AbstractThe design of physiologically relevant blood vessel in vitro models has been impaired by the difficulty to reproduce the complex architecture of native blood vessels and the mechanisms mediating key cellular functions within miniaturized perfusable systems. Aiming to simulate blood vessel walls, in this work innovative 2D platforms are designed and patterned with magnetic‐responsive gelatin for enabling in situ co‐culture of mesenchymal stromal cells (MSCs) and human umbilical vein endothelial cells (HUVECs) within confined compartments. The performance of the 2D chips is evaluated based on HUVECs migration, adherence, and angiogenic behavior (proliferation and sprouting), as well as production of Endothelin‐1 (endothelium marker), and compared with the results of 3D single channel models, designed to mimic the morphology of native arteries and veins. The 2D chips obtain better cell adhesion and angiogenic performance, which is attributed to flow profiles and VEGF concentration gradients. Magnetic stimulation is then used as a novel strategy to increase cell sprouting and endothelization ≈1.5 times above the control condition. These bio‐inspired devices advance the exploration of magnetism for a finer convergence to the native vascular conditions in vitro and improved modulation of angiogenesis, showing promising contributions to the development of sophisticated therapeutics for vascular ischemia‐related diseases.
Current progress in robotic hepatobiliary and pancreatic surgery at a high‐volume center
Authors: McCarron Frances N. , Vrochides Dionisios , Martinie John B. 
Published: September 2023

AbstractThere has been steady growth in the adoption of robotic HPB procedures world‐wide over the past 20 years, but most of this increase has occurred only recently. Not surprisingly, the vast majority of robotics has been in the United States, with very few, select centers of adoption in Italy, South Korea, and Brazil, to name a few. We began our robotic HPB program in 2008, well before almost all other centers in the world, with the most notable exception of Giullianotti and colleagues. Our program began gradually, with smaller cases carefully selected to optimize the strengths of the original robotic platform and included complex biliary and pancreatic resections. We performed the first reported series of choledochojejunostomy for benign biliary strictures and first series of completion cholecystectomies. We began performing robotic distal pancreatectomies and longitudinal pancreaticojejunostomies, reporting our early experience for each of these procedures. Over time we progressed to robotic pancreaticoduodenectomies. Initially, these were performed with planned conversions until we were able to optimize efficiency. Now we have performed over 200 robotic whipples, reaching a 100% robotic completion rate by 2020. Finally, we have added robotic major hepatectomies, including resections for hilar cholangiocarcinoma to our repertoire. Since the program began, we have performed over 1600 robotic HPB cases. Outcomes from our program have shown superior lymph node harvest, lower DGE rates, shorter hospitalizations, and fewer rehab admissions with similar overall complications to open and laparoscopic procedures, signifying that over time a robotic HPB program is not only feasible but advantageous as well.
Strong Protein Adhesives through Lanthanide‐enhanced Structure Folding and Stack Density
Authors: Chen Jing , Shi Weiwei , Ren Yubin , Zhao Kelu , Liu Yangyi , Jia Bo , Zhao Lai , Li Ming , Liu Yawei , Su Juanjuan , Ma Chao , Wang Fan , Sun Jing , Tian Yang , Li Jingjing , Zhang Hongjie , Liu Kai 
Published: September 2023

AbstractGenerating strong adhesion by engineered proteins has the potential for high technical applications. Current studies of adhesive proteins are primarily limited to marine organisms, e.g., mussel adhesive proteins. Here, we present a modular engineering strategy to generate a type of exotic protein adhesives with super strong adhesion behaviors. In the protein complexes, the lanmodulin (LanM) underwent α‐helical conformational transition induced by lanthanides, thereby enhancing the stacking density and molecular interactions of adhesive protein. The resulting adhesives exhibited outstanding lap‐shear strength of ≈31.7 MPa, surpassing many supramolecular and polymer adhesives. The extreme temperature (−196 to 200 °C) resistance capacity and underwater adhesion performance can significantly broaden their practical application scenarios. Ex vivo and in vivo experiments further demonstrated the persistent adhesion performance for surgical sealing and healing applications.
Enantioselektive Synthese von Arylglycinen durch Pd‐katalysierte Kupplung von Schöllkopf‐Bislactimethern mit Arylchloriden
Authors: Prendes Daniel Sowa , Papp Florian , Sankaran Nagesh , Sivendran Nardana , Beyer Frederike , Merten Christian , Gooßen Lukas J. 
Published: September 2023

AbstractArylglycine sind wichtige Pharmakophore, die in mehreren umsatzstarken Medikamenten enthalten sind. Diese Verbindungsklasse wurde nun durch eine Pd‐katalysierte Schöllkopf‐ähnliche Aminosäuresynthese aus reichlich vorhandenen Arylchloriden zugänglich gemacht. In Gegenwart des Katalysators Methylnaphthyl(XPhos)‐Palladiumbromid, der Base Lithium‐2,2,6,6‐Tetramethylpyrrolididid und des Additivs ZnCl2 wurden von tert‐Leucin abgeleitete Bislactimether bei Raumtemperatur effizient aryliert, wobei Ausbeuten von 95 % und Diastereoselektivitäten von 98 : 2 erreicht wurden. Die Hydrolyse ergab die entsprechenden Arylglycine in hohem Enantiomerenüberschuss.
Facile synthesis of cardanol‐based reactive diluents and application for anti‐shrinkage UV‐curable resins
Authors: Tong Shanyuan , Hu Yun , Jia Puyou , Ma Yufeng , Huang Qin , Hu Lihong , Zhou Yonghong 
Published: September 2023

AbstractBiomass resources possessed the advantages of being natural, renewable, abundant, inexpensive, and easy to degrade. Therefore, fabricated bio‐based UV‐curable materials have gradually attracted much more attention, which meet the requirements of sustainable development and save petrochemical resources. In this paper, cardanol was modified to synthesize radical reactive diluent and hybrid reactive diluent by a facial method and was used to adjust the viscosity and reduce the volume shrinkage of UV‐curable epoxy acrylic resin. The structure–activity properties and UV‐curing kinetics of the obtained UV‐curable materials were clarified, and the anti‐shrinkage mechanism was also explored. In addition, the obtained cardanol‐based materials were compared with petroleum based diluent methyl methacrylate (MMA) and application for UV‐curable coatings. The volume shrinkage of the cardanol‐based reactive diluents was 3.5% and 2.1%, respectively, which were lower than MMA (4.6%). The CC conversion of the cardanol‐based reactive diluent exhibited the highest value of 79.6%. This work provided a specific theoretical basis for the subsequent design and application of bio‐based UV‐curable resins. It is of certain significance to the alleviation of the shortage of petrochemical resources and the sustainable development of the UV‐curable coating industries.
A synthesis of the risks of marine light pollution across organismal and ecological scales
Authors: Miller Colleen R. , Rice Aaron N. 
Published: September 2023

Abstract

Light pollution is a pervasive global stressor to natural systems. However, due to the proximity of human activities along the coasts and open ocean, light is a pervasive yet commonly overlooked pollutant in many marine habitats.
There is a well‐developed body of literature on the visual physiology, behaviour and ecology of many marine taxa, and a re‐evaluation of these data can help inform risks of light pollution to impact marine organisms and ecosystems. This paper identifies key knowledge gaps in the study of marine light pollution ecology and recommends research and management foci for future study.
Most work on this pollutant has focused on terrestrial ecosystems and taxa, where experts have learned how anthropogenic light influences behaviour, reproduction cycles and population dynamics. However, light pollution bleeds far beyond the shores, affecting many sensitive ecosystems with light available at unnatural times with varied makeup, such as varying intensities or spectra.
This review discusses the current understanding of light dynamics underwater, photoreceptive systems of marine taxa and the documented ecological impacts. This lends a critical basis of understanding for the many gaps in marine light pollution biology. For example, little is known about effects of light on broad groups of marine taxa such as cetaceans, ecosystem‐level effects, or interactive impacts of light and other anthropogenic stressors. Light is a key structuring factor of the marine environment and can therefore elicit immense downstream effects on marine organisms individually, at the population‐ or ecosystem‐level.
Light pollution is an urgent concern for marine ecosystems because marine organisms have tight relationships with their natural light environment. As the world moves deeper into the Anthropocene, assessing and mitigating the risks of this pollutant to key environmental and economic marine systems is critical to maintaining a healthy ocean.
New data on mitogenomes of Thienemanniella Kieffer, 1911 (Diptera: Chironomidae, Orthocladiinae)
Authors: Qi Yan , Bu Wen‐Jun , Zheng Chen‐Guang , Lin Xiao‐Long , Jiao Ke‐Long 
Published: September 2023

AbstractThe mitochondrial genome (mitogenome) has been widely used as a powerful marker in phylogenetic and evolutionary studies of various Dipteran groups. However, only a few mitogenomes from the Thienemanniella genus have been reported till now. Furthermore, there is still indeterminacy in the phylogenetic relationships of the genus Thienemanniella. In this study, mitogenomes of five Thienemanniella species were sequenced and analyzed newly. Combined with the published mitogenome of Thienemanniella nipponica, the obtained results showed that mitogenomes of Thienemanniella were conserved in structure, and all genes were observed to be arranged in the same gene order as the ancestral mitogenome. Nucleotide composition varied significantly among different genes, and the control region displayed the highest A + T content. All protein coding genes are subjected to purification selection, and the fastest evolving gene is ATP8. Maximum likelihood and Bayesian inference analyses showed the phylogeny of Thienemanniella which was supported in five topologies. Our present study provides valuable insight into the phylogenetic relationships of Thienemanniella species.
Functional diversity of sodium channel variants in common eastern bumblebee, Bombus impatiens
Authors: Chen Longwei , Wang Yuquan , Zhang Kun , Wu Shaoying 
Published: September 2023

AbstractFor the past decade, Colony Collapse Disorder has been reported worldwide. Insecticides containing pyrethroids may be responsible for a decline in bees, which are more sensitive to pyrethroids compared with other insects. Voltage‐gated sodium channels (Nav) are the major target sites of pyrethroids, and the sodium channel diversity is generated through extensive alternative splicing and RNA editing. In this study, we cloned and analyzed the function of variants of the Nav channel, BiNav, from Bombus impatiens. BiNav covers a 46 kb genome region including 30 exons. Sequence analysis of 56 clones showed that the clones can be grouped into 22 splice types with 11 optional exons (exons j, w, p, q, r, b, e, t, l/k, and z). Here, a special alternative exon w is identified, encoding a stretch of 31 amino acid resides in domain I between S3 and S4. RNA editing generates 18 amino acid changes in different positions in individual variants. Among 56 variants examined, only six variants generated sufficient sodium currents for functional characterization in Xenopus oocytes. In the presence of B. impatiens TipE and TEH1, the sodium current amplitude of BiNav1‐1 increased by fourfold, while TipE of other insect species had no effect on the expression. Abundant alternative splicing and RNA editing of BiNav suggests the molecular and functional pharmacology diversity of the Nav channel for bumblebees. This study provides a theoretical basis for the design of insecticides that specifically target pests without affecting beneficial insects.
Easy Access to Tertiary Amines from Carbonyl Compounds with Substituted Amine‐Boranes: A Substrate, Catalyst, and Additive‐Free Approach Under Mild Conditions
Authors: Chowdhury Deep , Mukherjee Arup 
Published: September 2023

AbstractTertiary amines are ubiquitous and play an essential role in organocatalysis, pharmaceuticals, and fine chemicals. Amongst various synthetic procedures known for their synthesis, the reductive amination of carbonyl compounds has been found to be a proficient method. Over the past few decades, different synthetic strategies for reductive amination have been developed. Most of them suffer from the use of transition metals and/or harsh reaction conditions. Herein, we present an efficient, operationally simple protocol for the chemoselective transformation of carbonyl compounds to tertiary amines under benign conditions. The strategy encompasses a broad substrate scope under the metal‐free condition at room temperature and does not require any solvent. A detailed mechanistic investigation was performed with the aid of control experiments and computational study to shed light on the reaction pathway.
Direct Synthesis of Aldoximes: Ruthenium‐Catalyzed Coupling of Alcohols and Hydroxylamine Hydrochloride
Authors: Manikpuri Deepsagar , Sankar Raman Vijaya , Gunanathan Chidambaram 
Published: September 2023

AbstractA catalytic method for the direct synthesis of oximes from alcohols and hydroxyl amine hydrochloride salt is reported. The reaction is catalyzed by a ruthenium pincer catalyst, which oxidizes alcohols involving amine‐amide metal‐ligand cooperation, and the in situ formed aldehydes condense with hydroxyl amine to deliver the oximes. Notably, the reaction requires only a catalyst and base; water and liberated hydrogen are the only byproducts, making this protocol attractive and environmentally benign.
The positive and negative effects of working with child sexual abuse for health and social care professionals: A systematic review
Authors: Sheehan Diarmuid , Holland Jessica , Carr Alan 
Published: September 2023

AbstractThe aim of this systematic review was to determine the positive and negative outcomes of working with children who had experienced sexual abuse for health and social care professionals. The following four databases were searched using predetermined terms: PsycINFO, PubMed, CINAHL and Web of Science. Inclusion criteria included peer‐reviewed qualitative, quantitative, multi‐method or mixed method studies written in the English language. Study identification, quality assessment and data extraction were independently completed by two researchers, with a high degree of inter‐rater reliability. Eight studies (six qualitative, one quantitative and one multi‐method) met the inclusion criteria. Reviewed studies were conducted in the United States, Israel, Ireland and South Africa. Both positive and negative outcomes for healthcare professionals working with childhood sexual abuse (CSA) were identified. Additionally, a range of personal and contextual mitigating and risk factors were identified that may affect professionals' vulnerability to negative outcomes from CSA work, which have implications for practice. Due to the limited evidence base, clinical implications are tentative. Future research should adopt longitudinal methodologies and focus on participants from a range of disciplines and work contexts, particularly outside the United States.
Autophagy‐targeted nanoparticles in breast carcinoma: A systematic review
Authors: Golchin Asal , Maleki Masoumeh , Alemi Forough , Malakoti Faezeh , Yousefi Bahman 
Published: September 2023

AbstractBreast cancer is a commonly known cancer type and the leading cause of cancer death among females. One of the unresolved problems in cancer treatment is the increased resistance of the tumor to existing treatments, which is a direct result of apoptotic defects. Calculating an alternative to cell death (autophagy) may be the ultimate solution to maximizing cancer cell death. Our aim in this study was to investigate the potential of free nanoparticles (un‐drug‐loaded) in the induction or inhibition of autophagy and consider this effect on the therapy process. When the studies met the inclusion criteria, the full texts of all relevant articles were carefully examined and classified. Of the 25 articles included in the analysis, carried out on MCF‐7, MDA‐MB‐231, MDA‐MB‐231‐TXSA, MDA‐MB‐468, SUM1315, and 4T1 cell lines. Twenty in vitro studies and five in vivo/in vitro studies applied five different autophagy tests: Acridine orange, western blot, Cyto‐ID Autophagy Detection Kit, confocal microscope, and quantitative polymerase chain reaction. Nanoparticles (NPs) in the basic format, including Ag, Au, Y2O3, Se, ZnO, CuO, Al, Fe, vanadium pentoxide, and liposomes, were prepared in the included articles. Three behaviors of NPs related to autophagy were seen: induction, inhibition, and no action. Screened and presented data suggest that most of the involved free NPs (metallic NPs) in this systematic review had reactive oxygen species‐mediated pathways with autophagy induction (36%). Also, PI3K/Akt/mTOR and MAPK/ERK signaling pathways were mentioned in just four studies (16%). An impressive percentage of studies (31%) did not examine the NP‐related autophagy pathway.
Collateral grading systems in retrograde percutaneous coronary intervention of chronic total occlusions
Authors: Somsen Yvemarie B. O. , de Winter Ruben W. , Giunta Rocco , Schumacher Stefan P. , van Diemen Pepijn A. , Jukema Ruurt A. , Stuijfzand Wijnand J. , Danad Ibrahim , Lissenberg – Witte Birgit I. , Verouden Niels J. , Nap Alexander , Kleijn Sebastiaan A. , Galassi Alfredo R. , Henriques José P. , Knaapen Paul 
Published: September 2023

AbstractBackgroundThe Japanese Channel (J‐Channel) score was introduced to aid in retrograde percutaneous coronary intervention (PCI) of chronic total coronary occlusions (CTOs). The predictive value of the J‐Channel score has not been compared with established collateral grading systems such as the Rentrop classification and Werner grade.AimsTo investigate the predictive value of the J‐Channel score, Rentrop classification and Werner grade for successful collateral channel (CC) guidewire crossing and technical CTO PCI success.MethodsA total of 600 prospectively recruited patients underwent CTO PCI. All grading systems were assessed under dual catheter injection. CC guidewire crossing was considered successful if the guidewire reached the distal segment of the CTO vessel through a retrograde approach. Technical CTO PCI success was defined as thrombolysis in myocardial infarction flow grade 3 and residual stenosis <30%.ResultsOf 600 patients, 257 (43%) underwent CTO PCI through a retrograde approach. Successful CC guidewire crossing was achieved in 208 (81%) patients. The predictive value of the J‐Channel score for CC guidewire crossing (area under curve 0.743) was comparable with the Rentrop classification (0.699,p = 0.094) and superior to the Werner grade (0.663,p = 0.002). Technical CTO PCI success was reported in 232 (90%) patients. The Rentrop classification exhibited a numerically higher discriminatory ability (0.676) compared to the J‐Channel score (0.664) and Werner grade (0.589).ConclusionsThe J‐channel score might aid in strategic collateral channel selection during retrograde CTO PCI. However, the J‐Channel score, Rentrop classification, and Werner grade have limited value in predicting technical CTO PCI success.
Binuclear and Mononuclear Aluminum Complexes as Quick and Controlled Initiators of Well‐ordered ROP of Cyclic Esters
Authors: Sagar Shweta , Nath Priyanku , Bano Kulsum , Karmakar Himadri , Sharma Jyoti , Sarkar Alok , Panda Tarun K. 
Published: September 2023

AbstractDescribed herein is an efficient ring‐opening polymerization (ROP) of rac‐lactide and ϵ‐caprolactone (ϵ‐CL) using novel bimetallic and monometallic aluminum complexes supported by functionalized P−N ligands. All the aluminum complexes were seen to be active catalysts in the ROP of both rac‐lactide and ϵ‐CL in toluene at 60 °C. Bimetallic aluminum complex, [Al(Me)2{Ph2P(Se)N(CH2)2N−(CH2CH2)2O}(AlMe3)] containing an uncoordinated Se atom and an auxiliary Al atom within the proximity of another central Al cation was observed to exhibit the highest catalytic activity among all the catalysts studied. Kinetic experiments, comparing bimetallic and related monometallic complexes revealed that bimetallic cooperativity among the two metallic centers in bimetallic complex plays an essential role in driving such superior reactivity. We synthesized several isoselective polylactides (PLAs) and polycaprolactones (PCLs) with controlled molecular weights and narrow molecular weight distributions and characterized by 1H, 13C NMR, DSC and TGA.
Sustainable Photo‐ and Electrochemical Transformation of White Phosphorous (P4) into P1 Organo‐Compounds
Authors: Liu Yan , Chen Xiaolan , Yu Bing 
Published: September 2023

AbstractElemental white phosphorous (P4) is a crucial feedstock for the entire phosphorus‐derived chemical industry, serving as a common precursor for the ultimate preparation of high‐grade monophosphorus (P1) fine chemicals. However, the corresponding manufacturing processes generally suffer from a deep reliance on hazardous reagents, inputs of immense energy, emissions of toxic pollutants, and the generation of substantial waste, which have negative impacts on the environment. In this context, sustainability and safety concerns provide a consistent impetus for the urgent overall improvement of phosphorus cycles. In this Concept, we present an overview of the most recent growth in photo‐ and electrochemical synthesis of P1 organo‐compounds from P4, with special emphasis on sustainable features. The key aspects of innovations regarding activation mode and mechanism have been comprehensively analyzed. A preliminary look at the possible future direction of development is also provided.