bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compound Impacts of Monsoon and Westerlies on Summer Precipitation over Tibetan Plateau
Authors: Dong Xuefeng , Liu Yuzhi , Yan Xiaoqiang , Wang Yingsi , Tan Ziyuan , Luo Min , Li Dan , Wang Ying , Tang Shijia 
Published: July 2023

Abstract
South Asian summer monsoon (SASM) and westerlies are essential to the precipitation over Tibetan Plateau (TP) by transporting water vapor. Based on the latest reanalysis datasets, we investigate the compound mechanisms of SAMS and westerlies influencing summer precipitation over the TP. The results show that the summer precipitation over the TP is mainly modulated by two meridional Rossby wave trains which are linked to the compound impacts of SASM and westerlies over the TP (TPW). When both the SASM and the TPW are stronger, a cyclone over India and an anticyclone over Southeast Asia could jointly enhance the transport of warm and moist airflow to the TP along its southern boundary. Meanwhile, a cyclone over the northwestern TP and an anticyclone over the northeastern TP could induce the southward invasion of cold airflow. Consequently, the convergence of warm and cold airflows can result in more summer precipitation over the southern TP. On the contrary, when both the SASM and the TPW are weaker, a reversed pattern of above wave trains is stimulated, leading to more precipitation over the northeastern TP. Besides, with the stronger SASM and the weaker TPW configurated, anomalous moisture convergence (divergence) and ascending (descending) motion are found over the eastern (western) TP, producing more (less) precipitation over the eastern (western). Contrarily, with the weaker SASM and the stronger TPW configurated, the summer precipitation will be increased over the western TP. Overall, the compound impacts of SASM and TPW on the TP summer precipitation are significantly related to the dynamical processes instead of thermodynamic processes. These findings provide scientific basis and clues for the predictions of summer precipitation over the TP.
Prevalence of Mental Disorders among Middle-Aged Population of Primary Healthcare Centers in Northeastern Iran
Authors: Talebi Mehdi , Taghipour Ali , Raouf-Rahmati Amene , Farokhani Ehsan Musa , Jam Saeed Ghaffariyan , Samarghandi Azadeh , Nemati Ahmad 
Published: July 2023

Abstract
Background
Primary healthcare centers (PHCs) are the most accessible medical services in society. PHCs are responsible for screening, detecting, and treating health issues in people. This study aimed to investigate the prevalence of psychiatric disorders in middle-aged individuals who refer to PHCs and the potential of PHCs in diagnosing mental disorders.
Methods
This cross-sectional study was implemented at PHCs under the supervision of Mashhad University of Medical Sciences (MUMS) in northeast Iran. The enrolled subjects were middle-aged adults who had electronic medical records in SINA, an integrated health management system, and the electronic medical records of MUMS. The prevalence of psychiatric disorders by type and their relationship with demographic information was evaluated using a Chi-square test.
Results
This study involved 218,341 middle-aged participants. Prevalence of psychiatric disorders was 8.3%, and depression and anxiety were the most common psychiatric disorders. The prevalence of mental illnesses was significantly higher in women compared to men (10.1% vs 3.8%), those aged 46 to 60 compared to 30–45 years old (10.2% vs. 6.4%), and in rural residents compared to urban residents (11.5% vs. 6.5%).
Conclusions
Considering the previous studies in Iran, the prevalence of mental disorders among patients presenting to PHCs was noticeably lower than expected rates. It seems probable that this huge difference is due to poor screening and detection of mental illness in PHCs of MUMS. It is recommended that health policymakers pursue specific measures to make PHCs more helpful for people with mental health problems in the community.
Necessary Conditions for Turnpike Property for Generalized Linear-quadratic Problems
Authors: Li Zhuqing , Guglielmi Roberto 
Published: July 2023

Abstract
In this paper, we derive several necessary conditions of turnpike property for generalized linear-quadratic (LQ) optimal control problem in an infinite dimensional setting. The turnpike property reflects the fact that over a sufficiently large time horizon, the optimal trajectories and optimal controls stay for most of the time close to a prescribed steady state of the system. We show that the turnpike property is strongly connected to certain structural-theoretical properties of the control system. We provide suitable conditions to characterize the turnpike propertyin terms of the detectability and stabilizability of the system. Later, we show the equivalence between the exponential turnpike property for generalized LQ and LQ optimal control problems.
Transition Shock among Nursing Interns and its Relationship with Patient Safety Attitudes, Professional Identity and Climate of Caring: A Cross-Sectional Study
Authors: Zhao Sha , Liang Qinglong , Tao Hong , Fan Sisi , Xia Yuting , Zeng Lihong , Wang Guiyun , Liu Huan , Huang Hui , Xiao Jinnan 
Published: July 2023

Abstract
Background: Nursing interns often experience lots of challenges during their clinical nursing internships, which can adversely affect career decisions and result in a squandering of nursing education resources. Patient safety attitudes, professional identity and climate of caring may affect nursing interns’ clinical experience. However, more evidence is requested to validate these relationships for nursing educators to develop effective education programs and facilitate interns’ successful transition.
Methods: This was a cross-sectional study, which used a convenience sampling method to recruit 387 nursing interns during December 2022 to April 2023 in university affiliated hospital in Hunan province, China. Data were collected using standardized scales. Spearman correlation and multiple regression analysis were employed to examine the relationship between transition shock, patient safety attitudes, professional identity, and climate of caring.
Results: Nursing interns experienced transition shock at moderate levels and the highest levels of transition shock in response to overwhelming practicum workloads, with the second being related to the conflict between theory and practice. Transition shock was negatively correlated with patient safety attitudes, professional identity and climate of caring among nursing interns.
Conclusions:Understanding the current level of transition shock among nursing interns can provide nursing educators and administrators with opportunities for reflection and subsequent personal and professional growth. Findings from this study identified the transition shock experienced by nursing interns at moderate levels, the dimensions of overwhelming practicum workloads and conflict between theory and practice scored high, which complimented previous quantitative research, and the correlation results showed that transition shock were negatively correlated with professional identity, patient safety attitudes, and climate of caring. Nursing manager and educators can use these results to build a more comprehensive educational programme and provide nursing interns with a caring environment in the clinical setting to facilitate their professional growth.
Un-supervised classification of ICU patients according to congestion endotypes identifies clinical profiles associated with distinct outcomes: theCodOrea study.
Authors: Guinot Pierre-grégoire , Longrois Dan , Andrei Stefan , Nguyen Maxime , Bouhemad Belaid 
Published: July 2023

Abstract
Purpose
In the intensive care unit (ICU), fluid overload and congestion is of daily concern. To date, congestion is defined as the linear evolution of several features, including hemodynamic and ultrasound parameters. Nevertheless, at bedside, those ultrasound features are often dissociated leading to the hypothesis that several endotypes of congestion might exist in the ICU. The aim of this study was to identify endotypes of congestion and their association to outcomes.
Methods
We analysed 145 patients admitted to four ICUs. Various parameters related to volume status, filling pressure, and venous congestion (fluid overload, NT-pro BNP, central venous pressure (CVP), mitral E/e' ratio, systolic/diastolic ratio of flow velocity of hepatic veins, mean inferior vena cava (IVC) diameter and its variations, stroke volume change following passive leg raising, portal vein pulsatility index, venous renal impedance) were recorded. First, unsupervised hierarchical clustering was used to identify patients endotypes. Then, we described those endotypes to allow identification of patients at bedside.
Results
Three distinct endotypes were identified: (1) "hemodynamic congestion" endotype (n = 75) with moderate alterations of ventricular function, increased CVP and left filling pressure, and mild fluid overload; (2) “volume overload congestion” endotype (n = 50); with normal cardiac function and filling pressure despite highly positive fluid balance (overload); (3) "systemic congestion" endotype (n = 20) with severe alterations of left and right ventricular function, increased CVP and left ventricular filling pressure values. These three sub-endotypes differed significantly by the cause of admission to ICU, the incidence of acute kidney injury, mortality and ICU/hospital length of stay.
Conclusion
Our un-supervised machine learning analysis identified three distinct sub- endotypes of “congestion” in ICU patients with different pathophysiologic correlates and outcomes. We also highlight key ultrasonographic features that allow identification of those endotypes at bedside.
Bayesian Analysis for three parameter Generalised Rayleigh Distribution
Authors: Gautam Prem Lata , Kumar Surinder , Singh Vaidehi 
Published: July 2023

Abstract
In this article, Risk, posterior risk and Bayes risk is obtained for the parameters of the three parameter Generalised Rayleigh Distribution under type II censoring. Here we are considering the positive and negative powers of the parameters. Bayes estimators of the reliability function R(t) = Pr(X > t) and the stress-strength model P = Pr(X > Y) is also obtained with the help of Bayes estimators. Numerical findings are presented through the Tables and Figures.
A model for low-frequency, anisotropic wind fluctuations and coherences in the marine atmosphere
Authors: Syed Abdul Haseeb , Mann Jakob 
Published: July 2023

Abstract
To assess dynamic loads, large offshore wind turbines need detailed and reliable statistical information on the inflow turbulence. We present a model that includes low frequencies down to $\sim 1$ hr$^{-1}$ using the observed $S(f) \propto f^{-5/3}$ in that range. The presented model contains a parameter representing the anisotropy of the two-dimensional, incompressible turbulence and it assumes the low-frequency fluctuations to be homogeneous in the vertical direction. Combined with a three-dimensional model for the smaller scales, the model can predict correlations between different points. We have validated the model against two offshore wind data sets: a nacelle-mounted, forward-looking Doppler lidar with four beams at the Hywind Scotland offshore wind farm, and sonic anemometer measurements at the FINO1 research platform in the North Sea. One-point auto spectra and two-point cross spectra were calculated after splitting the data into different atmospheric stability classes. The relative strength of the 2D low-frequency fluctuations to the 3D fluctuations was higher under stable conditions. The combined 2D+3D model was able to fit the measured spectra with good accuracy and could then predict the two-point cross spectra, co-coherences, and phase angles between wind fluctuations at different lateral and vertical separations. Good agreement was found between the measured and predicted values, albeit with exceptions. The model can generate stochastic wind fields for investigating wake meandering in wind farms or dynamic loads on floating wind turbines.
The effects of COVID-19 on semen parameters in healthy males
Authors: Erdik Anıl , Gokce Asli Merve , Gokce Ahmet 
Published: July 2023

Abstract
BACKGROUND
To investigate the effects of the novel coronavirus disease 2019 (COVID-19) on spermatogenesis and the potential impact of COVID-19 on patients with normal semen parameters before the diagnosis of COVID-19.
RESULTS
The mean age of the patients was 31.82 ± 5.93 years. An abnormality was detected in at least one parameter in the semen analysis after COVID-19 in 9 patients (40.90%) whose semen analysis was normal before COVID-19. When post-COVID-19 sperm samples of the patients were divided into two groups as normal and abnormal, in the abnormal group, motility, progressive motility, and morphology were found to be significantly decreased, immotility significantly increased, and semen pH tended to be more alkaline.
CONCLUSIONS
Even though the effects of COVID-19 on spermatogenesis are not clearly understood, COVID-19 infection may have negative effects on semen parameters and play a role in fertilization. The expected duration for spermatogenesis to show normal findings may be longer in persons with post-COVID-19 infection.
Efficient Bis(indoyl)methanes Synthesis Enabled by SnO2/SiO2 Nanocomposite
Authors: Yelwande Ajeet A. , Navgire Madhukar E. , Lande Machhindra K. 
Published: July 2023

Abstract
This study focuses on the synthesis of SnO2/SiO2 nanocomposite materials using sol-gel and investigated its role in the synthesis of bis(indoyl)methanes via Friedel-Craft alkylation route. The prepared catalysts were characterized using various analytical techniques including X-ray diffraction spectroscopy (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FT-IR), temperature-programmed desorption of ammonia (NH3-TPD) and Brunauer-Emmett-Teller (BET). The developed method offers several advantages such as a simple workup procedure, high yield, non-toxicity, cleanliness, and the ability to recycle and reuse the catalytic materials. These findings demonstrate the potential of SnO2/SiO2 nanocomposites as efficient and environmentally friendly catalysts for the synthesizing Bis(indoyl)methane derivatives.
Effect of methanol-based vitrification solutions on the survival rate of cryopreserved common carp (Cyprinus carpio) embryos
Authors: Keivanloo Saeide , Sudagar Mohammad , Abualreesh Muyassar 
Published: July 2023

Abstract
The objective of this study was to establish an optimal protocol for the vitrification of common carp embryos. Additionally, the cryoprotective efficiency of natural honey as a non-permeable cryoprotectant was also examined. Six methanol-based vitrification solutions (V1–V6) were designed to be checked for their effects on the heartbeat stage embryos using a four-step protocol. Methanol-based vitrification solutions contained 4 M methanol + one or two other permeable cryoprotectants + 20% sucrose or natural honey. Toxicity tests showed that the hatching rates of embryos after exposure to V5 and V6 were significantly higher than those of other solutions (P < 0.05). Embryos were cryopreserved in the six vitrification solutions in liquid nitrogen (LN2, -196°C) for 30 and 60 min. After thawing (in a water bath at 24°C for 30 s), all vitrification solutions produced hatched larvae. The results revealed that V6 (4 M methanol + 3 M dimethyl sulfoxide + 2 M propylene glycol + 20% honey) was the most effective for cryopreservation of common carp embryos. The highest hatching rates after storage for 30 and 60 min in LN2 were 44.76% and 17.14%, and the highest survival rates were 36.19% and 11.42%, respectively. The mean normal development rates for vitrified-thawed embryos after 30 and 60 min of storage in LN2 were 14.28% and 2.38%, respectively. As natural honey showed greater cryoprotective efficiency than sucrose for common carp embryos, it is suggested that it can be used instead of sucrose, which is traditionally used in fish embryo cryopreservation.
Use of Glass-ionomer cement as a restorative material: a systematic review
Authors: Panetta Alessandro , Lopes Pedro Campos , Novaes Tatiane Fernandes , Rio Rute , Mello-Moura Anna Carolina Volpi 
Published: July 2023

Abstract
Background: The clinical applications of glass ionomers cements (GICs) are varied: restoration, lining material, sealing, hyper sensibility care and temporary cavity restoration. Due to the lack of physical properties, over time modifications of GICs were experimented and studied by the addition of metals, fibers, ceramics to the GIC powder in the attempt to overcome these problems and improve the material and clinical performance. The aim of this study was to evaluate whether primary and permanent teeth can be definitively restored with glass ionomer cements, based on the PICO(S) question “What is the clinical performance in primary and permanent teeth restored with glass ionomer cements?”,
Methods: A systematic search of the studies available in the literature was conducted in the electronic databases MEDLINE/Pubmed, Scopus and Web of Science. Two independent, calibrated examiners. The eligibility criteria were: (1) to be a systematic review (2) to evaluate the clinical longevity of GICs in primary and permanent teeth (3) to be clinical trials. The systematic reviews that met these criteria were reviewed in their entirety and those who presented at least one of the following exclusion criteria were then considered ineligible: (1) not being a systematic review of clinical trials; (2) not evaluating the longevity/clinical performance of GICs; (3) studies of dental restorative materials in teeth with enamel alterations.
Results: A systematic literature search in MEDLINE/PubMed, Scopus and Web of Science databases identified 132 references potentially relevant. Twenty-four eligible articles were identified, only 13 articles were included. Methodological quality was measured using the AMSTAR-2 tool and the risk of bias of the included systematic reviews by the ROBIS tool. The level of evidence analysis was performed using the GRADE tool.
Conclusions: Glass ionomer cements seems to be a viable choice in both dentitions, but primary dentition presents more evidence, especially regarding the Atraumatic Restorative Treatment (ART) technique. There is conflicting evidence on which type of glass ionomer is the best and comparisons to other dental materials are lacking. In conclusion, more high-quality studies are needed with longer follow up periods (>6 years), especially in permanent teeth.
Systematic review registration: This study was registered on the PROSPERO (International prospective register of systematic reviews) with registration CRD42022320602.
Significant response from fruquintinib plus anti-PD-1 immunotherapy for microsatellite stable metastatic colorectal cancer with liver and lung metastasis in the third line: A case report
Authors: He Lina , Cheng Xiaojiao , Zhou Cong , Li Qingli , Zhang Baiwen , Cheng Xin , Tu Shuiping 
Published: July 2023

Abstract
Background: The treatment in patients with metastatic colorectal cancer (mCRC) has limited options. About 90% of CRC patients with mismatch repair proficient/microsatellite stable (pMMR/MSS) tumors, were almost unresponsive to PD-1 antibody treatment. This report shows that a patient with pMMR/MSS mCRC achieved significant response from tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor (VEGFR) family (VEGFR-1,2,3) (fruquintinib) plus anti-PD-1 immunotherapy in the third line, providing a reference for the treatment of some MSS mCRC patients.
Case presentation: This case described a 65-year-old male with CRC who was diagnosed with pT4aN2bM0, IIIC and pMMR/MSS after curative surgery in August, 2018. Subsequently, he received adjuvant chemotherapy(FOLFOX for 5 cycles), first-line treatment(pelvic radiation plus capecitabine) and second-line treatment(TOMIRIplus cetuximab for 2 cycles), but lung, liver, and pelvic cavity metastases worsened in October 2019. Thus, he began receiving the fruquintinib plus PD-1 inhibitor(FP) regimen as third-line treatment and after three cycles, the size of the lung lesions was significantly reduced and evaluated as partial response(PR), while the liver and pelvic cavity lesions remained stable. As of December 2021, he had received a total of 33 courses of FP regimen. On February 17, 2022, the liver lesions were progressed. In brief, he achieved a long progression-free survival(PFS) of 28 months and overall survival(OS) of 40 months from the third-line treatment. Additionally, the patient tolerated the combined treatment.
Conclusions: Fruquintinib combined with immunotherapy exerted good therapeutic effects with safety, and may bring more clinical benefits to MSS mCRC patients, especially with lung metastasis.
P4HA2 promotes proliferaton, invasion and metastasis through the regulation of the PI3K/AKT signaling pathway in oral squamous cell carcinoma
Authors: Chi Zengpeng , Wang Qimin , Tong Lei , Li Dagang , Qiu Jing , Yang Fang , Guo Qingyuan , Zheng Jiawei , Chen Zhenggang 
Published: July 2023

Abstract
Proline 4-hydroxylase 2 (P4HA2) has been reported as a protein with hydroxylase activity that mainly plays a role in hydroxylation of collagen precursors and promoting collagen cross-linking under physiological conditions; its overexpression has been confirmed to exert a certain influence on a wide variety of malignant tumors’ occurrence and development. whereas its effects and possible mechanism in OSCC are unclear. In this study, a focus was placed on the investigation of the expression pattern, functions of carcinogenesis, and underlying mechanisms of P4HA2 in OSCC cells. The TCGA, UALCAN, GEPIA and K-M plotter databases and paraffin samples were employed to identify the P4HA2 expression in cancer and its relationship with clinicopathological features. Subsequently, P4HA2 knockdown and overexpression cell models were built, with the aim of assessing its oncogenic roles and mechanisms. Thus, as indicated by the result, P4HA2 was subjected to overexpression in OSCC and showed an inverse correlation with patient survival. P4HA2 knockdown suppressed OSCC cells’ invasion, migration and proliferation in vitro and vivo, while P4HA2 overexpression exerted the opposite effect. Mechanistically, expressions of phosphorylated PI3K/AKT pathway were restrained after P4HA2 silencing. As revealed by the result of this study, P4HA2 serves as a promising biomarker for predicting prognosis in OSCC, thus exerting a certain effect on OSCC cells’ metastasis, invasion and proliferation on the basis of the PI3K/AKT signaling pathway regulation in the downstream.