bluuebunny/crossref_metadata_2025_split huggingface dataset:
Moving toward targeted eating disorder care for transgender, non‐binary, and gender expansive patients in the United States
Authors: Goetz Teddy G. , Wolk Courtney Benjamin 
Published: August 2023

AbstractObjectiveLiterature suggests that transgender, non‐binary, and/or gender expansive (TNG) people are more likely than cisgender peers to experience eating disorders (EDs) and engage in dangerous weight control behaviors. TNG individuals with EDs are dramatically higher risk for self‐harm behaviors, suicidal ideation, and suicidal behaviors than cisgender peers with EDs or TNG peers without EDs, and often engage in ED symptoms/behaviors to alleviate gender dysphoria. Yet, no treatment paradigms have yet been adapted for TNG‐specific ED care. This qualitative study aims to identify stakeholder needs from such care to inform future clinical interventions.MethodsWe elicited patient (n = 12) and mental health clinician (n = 9) stakeholder needs and preferences regarding TNG‐specific ED care. Semi‐structured interview guides informed by the Consolidated Framework for Implementation Research (CFIR) and a behavioral insights framework, EAST, were developed to ensure uniform inclusion and sequencing of topics and allow for valid comparison across interviews. Using a rapid analysis procedure, we produced a descriptive analysis for each group identifying challenges of and opportunities in providing ED care for TNG adults.ResultsStakeholders expressed needs and preferences for TNG‐specific treatment including that it be: (1) TNG‐affirming, weight‐inclusive, trauma‐informed, and anti‐racist; (2) delivered by an interdisciplinary team, including gender‐affirming care clinicians; (3) focused on parsing gender dysphoria from other body image concerns, building distress tolerance, and working toward gender euphoria (rather than body acceptance).DiscussionFuture work is needed exploring ED care delivery models that integrate gender‐affirming care services with mental health care. Such models may improve TNG access to ED treatment and recovery.Public SignificanceTransgender, non‐binary, and/or gender expansive (TNG) experience disproportionately high rates of eating disorders and have unique barriers to accessing care. In individual interviews, TNG adults with eating disorders and mental health clinicians who provide psychotherapy for eating disorders voiced desire for greater availability of TNG‐affirming, weight‐inclusive eating disorder care, integrated with other gender‐affirming care services. This informs future research developing eating disorder care for TNG individuals.
Multicomponent and Metal‐Free Diels–Alder/Aromatization Approach to the Stereospecific Synthesis of E‐(Hetero)Stilbenes and Diarylacetylenes
Authors: Ballarotto Marco , Cerra Bruno , Temperini Andrea 
Published: August 2023

AbstractHerein, we present a novel and metal‐free approach to the stereospecific synthesis of E‐stilbenes. Starting from substituted 6‐arylhexa‐3,5‐dien‐2‐ones, a multicomponent enolacetylation/intermolecular Diels–Alder reaction was performed using ethyl acetate as a green solvent. The obtained cycloadducts were then oxidized without purification to produce the stilbenic products in good yields up to 67 % and with complete (E)‐stereospecificity and regioselectivity. Moreover, heterostilbenes were synthetized using this approach, displaying the potential applications of this protocol in pharmaceutical and material sciences. The proposed methodology was further extended to the synthesis of diarylacetylenes, furnishing a new metal‐free synthetic access to this important class of compounds. Furthermore, DFT calculations were performed confirming a concerted [4+2] reaction mechanism of the key ring‐forming step. At last, the energetic analysis of the possible transition states helps to shed some light on the experimentally observed total regio‐ and chemoselectivity.
Model-Assisted Interpretation of 4,4′-Methylene Dianiline Adsorption on Soils at Micromolar Concentrations
Authors: Plehiers Patrick M. , Ward Lauren , West Robert J. , Boegi Christian 
Published: August 2023

Abstract
Adsorption kinetics and isotherms were determined for 4,4′-methylene dianiline (MDA) on five diverse soils at nominal concentrations of 0.01–1.0 mg L−1 (nominal soil loading 0.1–40 μg gs−1). The data were used to model the adsorption process based on the two-step mechanism that is characteristic of the adsorption of aromatic amines, consisting of a physical equilibrium between the aqueous phase and the soil organic matter and a chemical reaction between the adsorbed MDA and reactive sites in the soil organic matter. Generic parameters were determined that enabled application of the model to other soils, which was checked against previously published data for MDA adsorption. At the low concentrations evaluated, the adsorption process took place almost exclusively in the organic matter without the need to account for a separate ion exchange process with the soil mineral fraction. Physical adsorption was found to be mainly dependent on the protonation state of MDA and increased with decreasing pH of the soils. Because of the chemical reaction taking place, adsorption equilibrium constants (organic–carbon partition coefficient [KOC]) normalized to the organic carbon content in the soil gradually increased with time; and it was demonstrated that, at steady-state conditions, values of log KOC &gt; 3.5 can be expected for most any soil at conservatively estimated potential environmental MDA concentrations. Environ Toxicol Chem 2023;42:2580–2588. © 2023 SETAC
Statistical methods to detect mother–father genetic interaction effects on risk of infertility: A genome‐wide approach
Authors: Skodvin Siri N. , Gjessing Håkon K. , Jugessur Astanand , Romanowska Julia , Page Christian M. , Corfield Elizabeth C. , Lee Yunsung , Håberg Siri E. , Gjerdevik Miriam 
Published: August 2023

AbstractInfertility is a heterogeneous phenotype, and for many couples, the causes of fertility problems remain unknown. One understudied hypothesis is that allelic interactions between the genotypes of the two parents may influence the risk of infertility. Our aim was, therefore, to investigate how allelic interactions can be modeled using parental genotype data linked to 15,789 pregnancies selected from the Norwegian Mother, Father, and Child Cohort Study. The newborns in 1304 of these pregnancies were conceived using assisted reproductive technologies (ART), and the remainder were conceived naturally. Treating the use of ART as a proxy for infertility, different parameterizations were implemented in a genome‐wide screen for interaction effects between maternal and paternal alleles at the same locus. Some of the models were more similar in the way they were parameterized, and some produced similar results when implemented on a genome‐wide scale. The results showed near‐significant interaction effects in genes relevant to the phenotype under study, such as Dynein axonemal heavy chain 17 (DNAH17) with a recognized role in male infertility. More generally, the interaction models presented here are readily adaptable to the study of other phenotypes in which maternal and paternal allelic interactions are likely to be involved.
Intraoperative three‐dimensional scanning of head and neck surgical defects: Enhanced communication and documentation of harvested supplemental margins
Authors: Yun Jun , Su Vivian , Kapustin Danielle , Rubin Samuel J. , Brandwein‐Weber Margaret , Khan Mohemmed N. , Chai Raymond , Doyle Scott , Karasick Michael , Urken Mark L. 
Published: August 2023

AbstractBackgroundWe have demonstrated the effectiveness of 3D resection specimen scanning for communicating margin results. We now address the corresponding surgical defect by debuting 3D defect models, which allow for accurate annotations of harvested supplemental margins.MethodsSurgical defects were rendered into 3D models, which were annotated to document the precise location of harvested supplemental margins. 3D defect scans were also compared with routine 2D photography and were analyzed for quality, clarity, and the time required to complete the scan.ResultsForty defects were scanned from procedures including segmental mandibulectomy, maxillectomy, and laryngopharyngectomy. Average duration of defect scan was 6 min, 45 s. In six of ten 2D photographs, the surgeon was unable to precisely annotate the extent of at least one supplemental margin.Conclusion3D defect scanning offers advantages in that this technique enables documentation of the precise location and breadth of supplemental margins harvested to address margins at‐risk.
The interaction of global small vessel disease burden and Alzheimer's disease pathologies do not change the independent association of amyloid‐beta with hippocampal volume: A longitudinal study on mild cognitive impairment subjects
Authors: Yu Mengying , Feng Lufei , Zhao Xuemiao , Huang Qun , Xia Nengzhi , Xia Huwei , Wen Caiyun , Wang Meihao , Zhu Zili , Yang Yunjun ,   For the Alzheimer's Disease Neuroimaging Initiative
Published: August 2023

AbstractThe purpose of this study was to investigate whether the co‐existence of global small vessel disease (SVD) burdens and Alzheimer's disease (AD) pathologies change hippocampal volume (HV) and cognitive function of mild cognitive impairment (MCI) subjects. We obtained MRI images, cerebrospinal fluid biomarkers (Aβ1‐42 and p‐tau), and neuropsychological tests of 310 MCI subjects from ADNI. The global SVD score was assessed. We used linear regression and linear mixing effect to analyze the effects of global SVD burdens, AD pathologies, and their interactions (SVD*AD) on baseline and longitudinal HV and cognition respectively. We used simple mediation effect to analyze the influencing pathways. After adjusting for global SVD and SVD*AD, Aβ remained independently correlated with baseline and longitudinal HV (std β = 0.294, p = .007; std β = 0.292, p < .001), indicating that global SVD did not affect the correlation between Aβ and HV. Global SVD score was correlated with longitudinal but not baseline HV (std β = 0.470, p = .050), suggesting that global SVD may be more representative of long‐term permanent impairment. Global SVD, AD pathologies, and SVD*AD were independently correlated with baseline and longitudinal cognitions, in which the association of Aβ (B = 0.005, 95% CI: 0.005; 0.024) and p‐tau (B = −0.002, 95% CI: −0.004; −0.000) with cognition were mediated by HV, suggesting that HV is more likely to explain the progression caused by AD pathology than SVD. The co‐existence of global SVD and AD pathologies did not affect the individual association of Aβ on HV; HV played a more important role in the influence of AD pathology on cognition than in SVD.
TFRC in cardiomyocytes promotes macrophage infiltration and activation during the process of heart failure through regulating Ccl2 expression mediated by hypoxia inducible factor‐1α
Authors: Pan Yanyun , Yang Jinxiu , Dai Jin , Xu Xiaoming , Zhou Xinbin , Mao Wei 
Published: August 2023

AbstractBackgroundCardiac hypertrophy is an initiating link to Heart failure (HF) which still seriously endangers human health. Transferrin receptor (TFRC), which promotes iron uptake through the transferrin cycle, is essential for cardiac function. However, whether TFRC is involved in the process of pathological cardiac hypertrophy is not clear.MethodsTransverse aortic constriction (TAC) mouse model and mice primary cardiomyocytes treated with isoproterenol (ISO) or phenylephrine (PHE) were used to mimic cardiac hypertrophy in vivo and in vitro. Single cell RNA sequence data from heart tissues of TAC‐model mice was obtained from the Gene Expression Omnibus (GEO) database, and was analyzed with R package Seurat. TFRC expression and macrophage infiltration in the heart tissue were tested by immunofluorescent staining. Macrophage polarization was detected by Flow Cytometry. TFRC expressions were detected by qRT‐PCR, Western blot, and ELISA.ResultsTFRC expression is increased in the pathological cardiac hypertrophy of mice model and positively associated with macrophage infiltration. Furthermore, TFRC in cardiomyocytes recruits and activates macrophages by secreting C‐C motif ligand 2 (Ccl2) in the mice heart tissue with TAC surgery or in the primary cardiomyocytes stimulated with ISO or PHE to induce myocardial hypertrophy in vitro. Moreover, we find that TFRC promotes Ccl2 expression in cardiomyocytes via regulating signal transducer and activator of transcription 3 (STAT3). In addition, we find that increased TFRC expression in the HF tissue is regulated by hypoxia‐inducible factor‐1α (HIF‐1α).ConclusionThis in‐depth study shows that TFRC in cardiomyocytes promotes HF development through inducing macrophage infiltration and activation via the STAT3‐Ccl2 signaling, and TFRC expression in cardiomyocytes is regulated by HIF‐1α during HF. This study first uncovers the role of TFRC in cardiomyocytes on macrophage infiltration and activation during HF.
Targetoid‐like lesions and chilblain‐like erythema manifested on hands and feet: A case of Rowell syndrome from China
Authors: Li Yanqiao , Cheng Shi , Ying Chuanpeng , Li Ling , Wang Guangxing , Chen Xuejun 
Published: August 2023

AbstractBackground: Rowell syndrome (RS) is an uncommon condition characterized by erythema multiforme (EM)‐like lesions and lupus erythematosus. It is more common in females, and EM may be the first manifestation of the disease with positive autoantibodies, such as antinuclear antibody (ANA), SSA, SSB and rheumatoid factor. The pathogenesis of RS is unknown and is likely caused by drug induction, ultraviolet exposure and infection. Method: We describe a case of RS from China which presented as characteristic targetoid‐like lesions and chilblain‐like erythema on hands and feet. This is a case of RS in a female patient from the inpatient department of dermatology. Results: A 41‐year‐old female with systemic lupus erythematosus exhibited chilblain‐like erythema and characteristic EM lesions on her extremities. She tested positive for serum ANA (1:320) and anti‐double‐stranded DNA, as well as other autoantibodies. Systemic glucocorticoids and hydroxychloroquine worked effectively for her. Conclusion: The present case met diagnostic criteria of RS. Notably, there was a co‑occurrence of facial butterfly erythema, chilblain‐like erythema and EM lesions distributed on the limbs in this case.
Arbidol: The current demand, strategies, and antiviral mechanisms
Authors: Kang Yue , Shi Yin , Xu Silu 
Published: August 2023

AbstractBackgroundHigh morbidity and mortality of influenza virus infection have made it become one of the most lethal diseases threatening public health; the lack of drugs with strong antiviral activity against virus strains exacerbates the problem.MethodsTwo independent researchers searched relevant studies using Embase, PubMed, Web of Science, Google Scholar, and MEDLINE databases from its inception to December 2022.ResultsBased on the different antiviral mechanisms, current antiviral strategies can be mainly classified into virus‐targeting approaches such as neuraminidase inhibitors, matrix protein 2 ion channel inhibitors, polymerase acidic protein inhibitors and other host‐targeting antivirals. However, highly viral gene mutation has underscored the necessity of novel antiviral drug development. Arbidol (ARB) is a Russian‐made indole‐derivative small molecule licensed in Russia and China for the prevention and treatment of influenza and other respiratory viral infections. ARB also has inhibitory effects on many other viruses such as severe acute respiratory syndrome coronavirus 2, Coxsackie virus, respiratory syncytial virus, Hantaan virus, herpes simplex virus, and hepatitis B and C viruses. ARB is a promising drug which can not only exert activity against virus at different steps of virus replication cycle, but also directly target on hosts before infection to prevent virus invasion.ConclusionARB is a broad‐spectrum antiviral drug that inhibits several viruses in vivo and in vitro, with high safety profile and low resistance; the antiviral mechanisms of ARB deserve to be further explored and more high‐quality clinical studies are required to establish the efficacy and safety of ARB.
Why do Open Government Data initiatives fail in developing countries? A root cause analysis of the most prevalent barriers and problems
Authors: Alexopoulos Charalampos , Saxena Stuti , Janssen Marijn , Rizun Nina , Lnenicka Martin , Matheus Ricardo 
Published: August 2023

AbstractOpen government data (OGD) include the provision of government data, which have so far been reserved for the provision of public utilities and services, wherein different stakeholders may create value out of the same source. Recently, OGD initiatives around the world have dampened or were found to be inadequate for one or other reasons. The present study seeks to underline the root causes behind these inadequate or stalled initiatives with a specific focus on the developing countries. This article undertakes a literature review of the most significant studies in this area, followed by a root cause analysis wherein the database across Scopus and Web of Science has been explored with the set inclusion and exclusion criteria being set in line with the research focusing on the hinderances and bottlenecks behind the failure of OGD initiatives (n ~ 15), thus not only summarizing what has been revealed in previous studies but also identifying these “root‐cause” relationships, which are responsible for the stalled OGD projects. A deep understanding of the literature on OGD shows that research of OGD barriers repeat each other. The results show that the main root causes include politico‐administrative, social, technological, legal and organizational (inter‐ and intra) dimensions including aspects like state of the economy, infrastructural issues, the tendency to copy the OGD initiative without need to institutionalize the same, and so forth. Whereas a number of studies are available covering the barriers in the roll‐out and implementation of OGD initiatives, the root causes behind the existence of these barriers have not been identified so far‐the present study seeks to plug this gap. Besides being a contribution to the extant OGD literature in general, the study seeks to leave academic and practical implications for furthering up deliberations and discussions on the OGD themes with specific impetus upon the cause analysis of the failure in OGD initiatives and the manner in which the same may be corrected or preempted.
Active disturbance rejection control: an application to continuous microalgae photobioreactors
Authors: Sangregorio‐Soto Viyils , Mazzanti Gianfranco , Cortés‐Romero John A. , Garzón‐Castro Claudia L. 
Published: August 2023

AbstractBACKGROUNDMathematical modelling is a widely employed approach for investigating the growth behaviour of microalgae. As a result, the development of model‐based controllers to regulate process variables has garnered increasing attention. However, despite the significant efforts invested in this area, control performance can be adversely affected by unmodelled dynamics and disturbances.RESULTSTwo active disturbance rejection controllers (ADRC) were designed to enable robust tracking of biomass concentration in continuous microalgae photobioreactors, with reduced reliance on the mathematical model of the system. The controllers were tuned to achieve a nonovershoot response and minimize settling time based on the culture's characteristics. Simulations were performed using optimal setpoints specific to each model. The results showcased a maximum output signal deviation of ±2.2%, ±7.8% and ± 7.62% for the Dunaliella tertiolecta, Isochrysis affinis galbana and Chlorella vulgaris models, respectively, regardless of the presence of simulated disturbances.CONCLUSIONSThe findings of this study significantly contribute to the advancement of the field of sustainable microalgae production. By introducing less dependent model‐based controllers, this research enhances the feasibility of implementing robust control strategies. These controllers require only knowledge of the equation system's order and the control gain function, simplifying the design process. This approach effectively addresses control performance degradation arising from unmodelled dynamics and disturbances. The ability to maintain desired process variables through ADRC controllers not only ensures improved control performance, but also supports the cultivation of specific microalgal species, when an accurate model is not available, thus promoting the overall progress and viability of microalgae biomass production. © 2023 Society of Chemical Industry.
Exploring scenario‐based assessment of students' global engineering competency: Building evidence of validity of a China‐based situational judgment test
Authors: Davis Kirsten A. , Jesiek Brent K. , Knight David B. 
Published: August 2023

AbstractBackgroundEngineers operate in an increasingly global environment, making it important that engineering students develop global engineering competency to prepare them for success in the workplace. To understand this learning, we need assessment approaches that go beyond traditional self‐report surveys. A previous study (Jesiek et al., Journal of Engineering Education 2020; 109(3):1–21) began this process by developing a situational judgment test (SJT) to assess global engineering competency based in the Chinese context and administering it to practicing engineers.PurposeWe built on this previous study by administering the SJT to engineering students to explore what prior experiences related to their SJT performance and how their SJT performance compared with practicing engineers' performance on the SJT.MethodEngineering students completed a survey including the SJT and related self‐report survey instruments. We collected data from three groups of students: those who had studied abroad in China; those who had studied abroad elsewhere; and those who had not studied abroad.ResultsWe found that students' SJT performance did not relate to their scores on the self‐report instruments, but did relate to their participation in study abroad programs. The students also performed better on the SJT when compared to the practicing engineers.ConclusionsOur results highlight the need to use multiple forms of assessment for global engineering competence. Although building evidence for the validity of the Global Engineering Competency China SJT is an ongoing process, this data collection technique may provide new insights on global engineering competency compared to traditionally used assessments.