bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early diagnosis of sinusoidal obstruction syndrome after hematopoietic stem cell transplantation, with modified diagnostic criteria including refractory thrombocytopenia
Authors: Ichikawa Hiroya , Yakushijin Kimikazu , Miyata Yoshiharu , Kanehira Hirofumi , Joyce Miki , Hirakawa Yuri , Matsumoto Sakuya , Nagao Shigeki , Sakai Rina , Kurata Keiji , Kitao Akihito , Saito Yasuyuki , Kawamoto Shinichiro , Yamamoto Katsuya , Ito Mitsuhiro , Murayama Tohru , Matsuoka Hiroshi , Minami Hironobu 
Published: June 2023

AbstractSinusoidal obstruction syndrome (SOS) is a fatal complication of hematopoietic stem cell transplantation (HSCT). Early diagnosis for SOS can improve clinical outcomes significantly. Here, we performed a retrospective study to investigate the Cairo diagnostic criteria, in which SOS was defined as the development of two or more in seven events, including transfusion‐refractory thrombocytopenia. Among 154 cases of allogeneic HSCT, 10 cases of SOS using the European Society for Blood and Marrow Transplantation criteria (EBMT16) as the reference standard were identified. The original Cairo criteria could diagnose SOS 5 days earlier than any other established criteria, with some false‐positive results (sensitivity = 100.0%; specificity = 72.2%). When the cutoff was set to three events for the Cairo criteria, the diagnosis of SOS could be made 3 days earlier than that using the EBMT16 criteria, with comparable precision (specificity = 86.1%). The accuracy of the Cairo criteria improved further when the cutoff point was set to four (specificity = 93.8%). The fulfillment of the Cairo criteria was associated with high mortality. Based on our results, the Cairo criteria were also considered clinically useful, especially at three or four cutoff points. Further studies are required to validate and refine the criteria.
Who benefits from the procurement financed by Multilateral Development Banks?
Authors: Martínez‐Galán Enrique , Proença Isabel 
Published: June 2023

AbstractWe use a gravity model to inquire about the factors that influence the amount of public procurement awarded by developing countries with funding from Multilateral Development Banks (MDBs), based on 169 000 contracts. We reach four main conclusions. First, procurement disproportionately benefits firms of low‐ and middle‐income countries and not those of MDBs' larger shareholders. Second, firms of upper‐middle‐income countries can compete successfully with those of developed countries. These two conclusions are in line with MDBs' development mandate. However, we also find that certain MDBs favour domestic firms and that having good diplomatic relations matters when awarding contracts.
サイトメガロウイルス感染症の診断に苦慮したことにより血栓性微小血管症で死亡した1例(A case of thrombotic microangiopathy who died due to difficulty in diagnosing cytomegalovirus infection)
Authors: 亮輔 土屋 , 義孝 大谷 , 秀平 宮田 , 智子 足立 , 博史 坂本 , 博史 小川 , 学 根本 
Published: June 2023

要旨　原因不明の血栓性微小血管症で死亡し，病理解剖でサイトメガロウイルス感染症と診断された1例を報告する。71歳の女性。意識障害で当院に搬送された。来院時より意識障害，ショックが遷延しており，多量の暗赤色水様便を認めた。体幹部CTで右鼠径部リンパ節腫脹，小腸の造影増強が見られたが診断に至らなかった。第2病日に破砕赤血球，血小板減少，肝機能障害，腎機能障害が出現し，原因不明の血栓性微小血管症と診断した。対症療法として持続的腎代替療法および輸血，抗菌薬を継続したが暗赤色水様便は持続した。サイトメガロウイルス抗原は陰性であった。第27病日に腸炎の精査目的に施行した大腸内視鏡検査で回盲部から上行結腸にかけてびらんと白苔が見られたが病理組織でも確定診断に至らず，第48病日に死亡退院した。死後の病理解剖で肺と胃，上行結腸，膵臓にサイトメガロウイルス感染症の所見が判明し，サイトメガロウイルス感染症に伴う血栓性微小血管症および多臓器不全と診断した。原因不明の消化器症状を呈した場合には，サイトメガロウイルス胃腸炎を常に鑑別に挙げ，抗原だけではなくPCRや病理組織の提出が必須である。また，免疫不全状態ではない患者に発症する可能性を念頭に置くべきである。
ワルファリンによる抗凝固薬関連腎症の1例(A case of anticoagulant–related nephropathy by warfarin)
Authors: 啓太 箕輪 , 達也 野田頭 , 有矢 吉村 , 英史 近藤 , 朋美 後村 , 仁志 森 
Published: June 2023

要旨　症例は86歳の女性。心房細動に対してワルファリン内服後に血尿を呈して前医を受診し，ワルファリンによる凝固障害と急性腎障害と診断された。ワルファリン休薬後2日目に心窩部痛を主訴に当院に救急搬送された。当院搬入時も凝固障害があり，胆道内出血と厚生労働省急性膵炎重症度判定基準で予後因子3点以上かつ造影CT grade 2の重症急性膵炎を合併していた。ワルファリン拮抗薬としてメナテトレノン製剤20mgを使用した。急性膵炎に対して輸液，胆道ドレナージや抗菌薬投与を行い，急性腎障害に関しては腎代替療法を行った。くも膜下出血を合併したが，病状は安定し，第17病日に透析を離脱した。凝固障害の改善後の第33病日に腎生検を施行した結果，赤血球円柱による尿細管の閉塞，尿細管上皮細胞傷害の所見を認め，ワルファリン腎症と診断された。その後，第52病日にエドキサバンの内服を開始し，第67病日に胆道ドレーンを抜去し，第77病日にリハビリ目的に転院した。抗凝固薬内服中に凝固障害かつ腎機能障害を呈した場合には抗凝固薬関連腎症も考慮し，迅速な凝固障害の正常化と確定診断のために腎生検を考慮すべきである。
急速に進行した気道閉塞に対して予防的に気管挿管を行ったCOVID–19合併外傷性咽頭後間隙血腫症例(A case of traumatic retropharyngeal hematoma in a patient with COVID–19 who underwent prophylactic tracheal intubation for rapidly progressing airway obstruction)
Authors: 俊宏 中井 , 英介 加古 , ももこ 杉山 , 哲也 田村 , 友紀 服部 , 寛 笹野 , 和哉 祖父江 
Published: June 2023

要旨　症例は45歳の男性。作業中に8mの高さから転落し，救急搬送された。全身CT検査で，第6，7頸椎棘突起骨折，第2–4胸椎棘突起骨折，第4，5胸椎破裂骨折，両側多発肋骨骨折が見られ，さらに偶発的にSARS–CoV–2抗原陽性が見つかった。神経損傷評価目的に受傷6時間後に行ったMRI検査で，第1–5頸椎椎体前面に血腫があり，咽頭後間隙血腫と判断した。呼吸困難はないものの，来院時のCT検査では見られなかった血腫が短時間で出現したことから，気道確保が必要と考えた。血腫による気道狭窄と頸椎保護が必要であることから気道確保困難が予測されたが，CT画像とMRI画像を基に気道を詳細に評価し，気管挿管可能と判断した。エアロゾル飛散に留意し，ビデオ喉頭鏡を用いた迅速導入で気管挿管を行った。1度の手技で気管挿管は成功した。その後，集中治療，胸椎破裂骨折に対する胸椎後方固定術，リハビリテーションを経て，独歩退院した。新型コロナウイルス感染症（以下，COVID–19）流行以降，エアロゾルに配慮した気道確保戦略が必要となっており，気道管理に対するリスクはより高まっている。本症例のようなCOVID–19を合併した気道確保困難症例では，患者の安全と医療者のエアロゾル暴露回避を両立させるため，感染防止策を十分に講じたうえで，気道確保困難に対する事前の気道評価と準備，症例に応じた的確な対応が必要である。
Development of a Silk Fibroin‐Small Intestinal Submucosa Small‐Diameter Vascular Graft with Sequential VEGF and TGF‐β1 Inhibitor Delivery for In Situ Tissue Engineering
Authors: Liu Zhengni , Rütten Stephan , Buhl Eva Miriam , Zhang Minjun , Liu Jiajie , Rojas‐González Diana M. , Mela Petra 
Published: June 2023

AbstractProper endothelialization and limited collagen deposition on the luminal surface after graft implantation plays a crucial role to prevent the occurrence of stenosis. To achieve these conditions, a biodegradable graft with adequate mechanical properties and the ability to sequentially deliver therapeutic agents isfabricated. In this study, a dual‐release system is constructed through coaxial electrospinning by incorporating recombinant human vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGF‐β1) inhibitor into silk fibroin (SF) nanofibers to form a bioactive membrane. The functionalized SF membrane as the inner layer of the graft is characterized by the release profile, cell proliferation and protein expression. It presents excellent biocompatibility and biodegradation, facilitating cell attachment, proliferation, and infiltration. The core‐shell structure enables rapid VEGF release within 10 days and sustained plasmid delivery for 21 days. A 2.0‐mm‐diameter vascular graft is fabricated by integrating the SF membrane with decellularized porcine small intestinal submucosa (SIS), aiming to facilitate the integration process under a stable extracellular matrix structure. The bioengineered graft is functionalized with the sequential administration of VEGF and TGF‐β1, and with the reinforced and compatible mechanical properties, thereby offers an orchestrated solution for stenosis with potential for in situ vascular tissue engineering applications.
NFT luxury brand marketing in the metaverse: Leveraging blockchain‐certified NFTs to drive consumer behavior
Authors: Sung Eunyoung (Christine) , Kwon Ohbyung , Sohn Kwonsang 
Published: June 2023

AbstractIndustry 4.0 technology enables luxury fashion brands in the virtual market to quantify the value of digital items in the metaverse; thus, brands can maintain their reputations, ensure consistent and integrated luxury brand marketing, and attract new consumers in the virtual market. Understanding consumer behavior toward buying digital assets (i.e., nonfungible tokens [NFTs]) is important. By using blockchain‐based NFTs as a way to verify the authenticity of digital assets in the virtual market, luxury brands can maintain their reputations and help consumers protect their digital assets. Thus, developing global marketing strategies supported by this technology is important for the success of luxury fashion brands in the metaverse. We conducted analyses to explore consumer behavior in the metaverse with regard to blockchain‐based luxury NFTs. The findings reveal the psychological evaluation process as a mechanism that drives consumer behavior toward NFT luxury brand fashion items in global virtual markets. The empirical findings also extend the application of game theory and prospect theory by revealing the psychological evaluation of risks associated with (not) buying luxury fashion NFTs as another mechanism driving consumer behavior in the metaverse.
Deimos: A novel automated methodology for optimal grouping. Application to nanoinformatics case studies
Authors: Varsou Dimitra‐Danai , Sarimveis Haralambos 
Published: June 2023

AbstractIn this study we present deimos, a computational methodology for optimal grouping, applied on the read‐across prediction of engineered nanomaterials’ (ENMs) toxicity‐related properties. The method is based on the formulation and the solution of a mixed‐integer optimization program (MILP) problem that automatically and simultaneously performs feature selection, defines the grouping boundaries according to the response variable and develops linear regression models in each group. For each group/region, the characteristic centroid is defined in order to allocate untested ENMs to the groups. The deimos MILP problem is integrated in a broader optimization workflow that selects the best performing methodology between the standard multiple linear regression (MLR), the least absolute shrinkage and selection operator (LASSO) models and the proposed deimos multiple‐region model. The performance of the suggested methodology is demonstrated through the application to benchmark ENMs datasets and comparison with other predictive modelling approaches. However, the proposed method can be applied to property prediction of other than ENM chemical entities and it is not limited to ENMs toxicity prediction.
Wideband and low profile multipolarization reconfigurable antenna based on metasurface
Authors: Li Long , Wu Zhao , Liang Jia‐Jun , Su Mei‐Li 
Published: June 2023

AbstractIn this letter, a wideband and low‐profile multipolarization reconfigurable antenna based on metasurface (MTS) is proposed. The antenna mainly contains two parts, an upper layer of MTS and a bottom layer of circular slot antenna. The MTS acts as a polarization controller, by mechanically rotating the MTS layer at a proper angle while keeping the circular slot antenna remain stationary, the polarization mode of the antenna can be switched to linear polarization (LP), left‐hand circular polarization (LHCP), and right‐hand circular polarization (RHCP). The experimented −10 dB impedance bandwidth of 37.8% and 54% for LP and circular polarization (CP) modes, respectively. The measured overlapped 3‐dB AR bandwidth is 22.2% for both CP modes, covering from 3.2 to 4 GHz. Moreover, the measured peak gain of the presented antenna reaches 9 dBi and 8 dBic for LP and CP modes, with a lower profile of 0.05 λ0.
Precapture of CO2 and Hydrogenation into Methanol on Heterogenized Ruthenium and Amine‐Rich Catalytic Systems
Authors: Szego Anthony E. , Church Tamara L. , Bacsik Zoltán , Jaworski Aleksander , Ullah Latif , Hedin Niklas 
Published: June 2023

AbstractA heterogenized alternative to the homogeneous precapture of CO2 with amines and subsequent hydrogenation to MeOH was developed using aminated silica and a Ru‐MACHOTM catalyst. Commercial mesoporous silica was modified with three different amino‐silane monomers and used as support for the Ru catalyst. These composites were studied by TEM and solid‐state NMR spectroscopy before and after the catalytic reaction. These catalytic reactions were conducted at 155 °C at a H2 and CO2 pressures of 75 and 2 bar, respectively, with the heterogeneous system (gas‐solid) being probed with gas‐phase infrared spectroscopy used to quantify the resulting products. High turnover number (TON) values were observed for the samples aminated with secondary amines.
Treatment of Laryngeal Verrucous Carcinoma: 28‐Year Retrospective Cohort Study and Literature Review
Authors: Amanian Ameen , Anderson Donald W. , Durham James Scott , Prisman Eitan , Ng Tony , Hu Amanda 
Published: June 2023

AbstractObjectiveLaryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. Although controversial, surgery has been the mainstay of treatment, due to concern about anaplastic transformation with radiotherapy. We aimed to study LVC patients to identify treatment patterns for primary and recurrent diseases.Study DesignRetrospective cohort study.SettingTertiary referral center.MethodsPatients with a pathological diagnosis of LVC treated over a 28‐year period were included. Baseline demographics, and treatment outcome measures including 5‐year laryngeal preservation rates (LPR), overall survival (OS), and recurrence‐free survival (RFS) were included. A literature review of published studies within the same study period was also completed.ResultsThirty‐two patients were included in the analysis (median age 61.5 years, 93.8% [30/32] male). Twenty‐three patients had T1 disease, and 9 had T2 disease with no evidence of regional or metastatic disease. The most common presenting symptom was hoarseness (93.8%) and the majority within the glottis 81.3% (26/32). Twenty‐nine patients underwent primary surgery only (28 local excisions, 1 vertical partial laryngectomy) meanwhile 3 underwent local excision with postoperative radiotherapy. LPR, OS, and RFS at 5 years were 95.8%, 90.1%, and 80.6%, respectively. Our literature review identified 23 previous studies, mostly single‐institution retrospective case series. Our study was the largest Canadian study in the literature to date.ConclusionAll LVC patients were treated with primary surgery, consistent with the current literature with excellent 5‐year OS and LPR. There was no consensus on the treatment of recurrent disease. Future prospective multicenter studies are warranted to further study this rare disease population.
Variance estimation of the risk difference when using propensity‐score matching and weighting with time‐to‐event outcomes
Authors: Cafri Guy , Austin Peter C. 
Published: June 2023

AbstractObservational studies are increasingly being used in medicine to estimate the effects of treatments or exposures on outcomes. To minimize the potential for confounding when estimating treatment effects, propensity score methods are frequently implemented. Often outcomes are the time to event. While it is common to report the treatment effect as a relative effect, such as the hazard ratio, reporting the effect using an absolute measure of effect is also important. One commonly used absolute measure of effect is the risk difference or difference in probability of the occurrence of an event within a specified duration of follow‐up between a treatment and comparison group. We first describe methods for point and variance estimation of the risk difference when using weighting or matching based on the propensity score when outcomes are time‐to‐event. Next, we conducted Monte Carlo simulations to compare the relative performance of these methods with respect to bias of the point estimate, accuracy of variance estimates, and coverage of estimated confidence intervals. The results of the simulation generally support the use of weighting methods (untrimmed ATT weights and IPTW) or caliper matching when the prevalence of treatment is low for point estimation. For standard error estimation the simulation results support the use of weighted robust standard errors, bootstrap methods, or matching with a naïve standard error (i.e., Greenwood method). The methods considered in the article are illustrated using a real‐world example in which we estimate the effect of discharge prescribing of statins on patients hospitalized for acute myocardial infarction.
Garcinone E suppresses breast cancer growth and metastasis by modulating tumor‐associated macrophages polarization via STAT6 signaling
Authors: Nie Xin , Fu Li , Cheng Yanfen , Wu Xiaoping , Lv Kongpeng , Li Renkai , Wu Yihan , Leung George Pak‐Heng , Fu Chaomei , Lee Simon Ming‐Yuen , Seto Sai‐Wang , Zhang Jinming , Li Jingjing 
Published: June 2023

AbstractCancer metastasis remains the most common cause of death in breast cancer patients. Tumor‐associated macrophages (TAMs) are a novel therapeutic target for the treatment of metastatic breast cancer. Despite the good anti‐cancer activity of garcinone E (GE), there are no reports on its therapeutic effects on breast cancer metastasis. The objective of this study was to examine the anti‐cancer effects of GE on metastatic breast cancer. RAW 264.7 and THP‐1 cells were polarized to M2 macrophages by IL‐4/IL‐13 in vitro. A 4T1 mouse breast cancer model and the tail vein breast cancer metastasis model were used to explore the effect of GE on breast cancer growth and metastasis in vivo. In vitro studies showed that GE dose‐dependently suppressed IL‐4 + IL‐13‐induced expression of CD206 in both RAW 264.7 cells and differentiated THP‐1 macrophages. However, GE did not affect the LPS + IFN‐γ‐induced polarization to the M1‐like macrophages in vitro. GE inhibited the expression of the M2 macrophage specific genes in RAW 264.7 cells, and simultaneously impaired M2 macrophage‐induced breast cancer cell proliferation and migration, and angiogenesis. In animal studies, GE significantly suppressed tumor growth, angiogenesis, and lung metastasis in 4T1 tumor‐bearing mice, without causing toxicity. In both tumor and lung tissues, the proportion of M2‐like TAMs was significantly decreased while the proportion of M1‐like TAMs was markedly increased by GE treatment. Mechanistically, GE inhibited phosphorylation of STAT6 in vitro and in vivo. Our results demonstrate for the first time that GE suppresses breast cancer growth and pulmonary metastasis by modulating M2‐like macrophage polarization through the STAT6 signaling pathway.
Review of packaging for improving storage quality of fresh edible mushrooms
Authors: Feng Yao , Xu Heran , Sun Yong , Xia Rongrong , Hou Zhenshan , Li Yunting , Wang Yafei , Pan Song , Fan Yiming , Zhu Jiayi , Xin Guang 
Published: June 2023

AbstractEdible mushrooms are favoured by people for their rich nutrition, medicinal value and unique flavour. The quality of postharvest mushroom decreased sharply because of its special tissue structure and physiological characteristics. Compared with other preservation technologies, packaging has been widely used in the preservation of mushrooms because of its strong preservation effect, green and convenient characteristic. This review discussed the quality deterioration of fresh mushrooms and its influencing factors, and summarised the research advances and preservation mechanism of modified atmosphere packaging (MAP), active packaging (ACP), biodegradable film packaging (BFP) and nanocomposite packaging (NCP) used to cope with the quality deterioration of fresh mushrooms. The packaging mainly maintains the quality of mushrooms and extends their shelf life by exerting antibacterial, antiviral and antioxidant, and by regulating respiration and energy metabolism, cell wall metabolism and membrane lipid metabolism. Currently, the combined packaging based on nano, active and biodegradable is getting more attention, but there is a lack of in‐depth genetic research on its preservation mechanism. Nanoemulsion‐based packaging was used in many foods; however, there is little research on the preservation of mushrooms. Based on the above packaging, the next step is to explore the intelligent packaging for edible mushrooms. This review can provide reference for further research and application of packaging preservation in mushrooms, to improve the quality of postharvest mushrooms.
Daycare shooting in Thailand: Time to address firearm violence as a global health issue
Authors: Budi Yasmine Syifa Nabila , Cathleen Fabiola , Jitanan Manatee , Butkatunyoo Oraphan , Miranda Adriana Viola 
Published: June 2023

AbstractOn 6 October 2022, a daycare shooting incident happened in Thailand. It is the deadliest mass shooting in Southeast Asian (SEA) countries and one of the many incidents contributing to the global epidemic of firearm‐related preventable violence. Although firearm violence is commonly associated with the United States, it is also a problem worldwide, causing long‐lasting health issues and huge economic burden. This is due to the root causes of firearm violence transcending national boundaries, including socioeconomic landscape, political dynamics, and globalization. Considering these and the major public health impacts of firearm violence, firearm violence should be prioritized as a global health issue. We identified public health challenges related to global firearm violence management: inadequate regulation, lack of official firearm surveillance, and inadequate access to mental health care. In Thailand, there is a gap in gun ownership policies for the civilian and government personnel and a relatively less strict background check compared to other SEA countries. It is crucial for the governments to strengthen their firearm regulations and invest in appropriate public health interventions, including improving access to mental health services and conducting firearm‐related surveillance and culturally sensitive awareness programs. Various public health stakeholders, including healthcare workers and local communities, should be engaged to effectively mitigate future firearm violence.
Electrochemical Quantification of Tyrosine in the Presence of Analogous Amino Acids
Authors: Amani‐Beni Zahra , Nezamzadeh‐Ejhieh Alireza 
Published: June 2023

AbstractAmnio acids are essential for body life, and thus, introducing novel simples/sensitive techniques/catalyst for detecting their low levels, especially in real samples and mixtures, is a great issue in analytical/bioanalytical chemistry. Thus, NiO nanoparticles were synthesized and used for the modification of a carbon paste electrode (CPE) for the square wave voltammetric (SqW) determination of tyrosine (Tyr) in the presence of tryptophan (Tryp), phenylalanine (PhA), and cysteine (Cis) amino acids (AA), all having the −CH2−CH(NH2)−COOH functional group. The calibration sensitivity was increased in interfering AA species which caused the decreased detection (for example, detection limit (DL) 1.32 μM to 0.88 μM Tyr) and quantification limits. For different concentrations of interfering AA species, the linear range (LR) was decreased that was more intense with an increase in AA amount. For example, the LR of 5–1800 μM Tyr in the absence of other AA species was changed to 80–800, 90–850, and 70 −1000 μM Tyr in the presence of 20 mM Tyr, Csy, and PhA, respectively. A g‐value of 0.487<g0.05,6,5=0.5875 confirmed the long‐term stability of the electrode for 4 months. The electrode showed good selectivity towards Tyr in the presence of some amino acids and inorganic salts. Recovery experiments also confirmed the good capability of the electrode in Tyr quantification in a complex matrix such as six human serums used.