bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Values of Primary Tumor Textural Heterogeneity and Blood Biomarkers in High-risk Neuroblastoma
Authors: Vural Ozge , Aydos Uguray , Okur Arzu , Pinarli Faruk Güçlü , Atay Lütfiye Özlem 
Published: April 2023

Purpose:
The aim of this study was to evaluate the prognostic value of textural parameters of primary tumors, serum lactate dehydrogenase (LDH), D-dimer, and ferritin in high-risk neuroblastoma patients.

Patients and Methods:
The imaging findings of 22 neuroblastoma patients (14 girls and 8 boys; age, 36.6 ± 34.2 [range: 5 to 138] months) who underwent 18-fluorodeoxyglucose positron emission tomography/computed tomography for primary staging before therapy between 2009 and 2020 were retrospectively evaluated. Positron emission tomography-derived metabolic data (maximum standard uptake value, mean standard uptake value, metabolic tumor volume, and total lesion glycolysis) and textural features of primary tumors were obtained. Serum LDH, D-dimer, and ferritin levels at the time of diagnosis were recorded. Univariate and multivariate Cox proportional hazards regression models were used to identify predictors for progression-free survival (PFS) and overall survival (OS). Survival curves were estimated by using the Kaplan-Meier method.

Results:
The median follow-up duration after diagnosis was 63 months (range: 5 to 141 mo). The median PFS and OS in all patients were 19 and 72 months, respectively. In multivariate Cox regression analyses with backward stepwise selection, grey level size zone matrix_size zone emphasis (GLSZM_SZE) was found as an independent predictor for both PFS and OS. Serum ferritin level was also found as an independent predictor for PFS. The Kaplan-Meier survival analysis showed that higher serum LDH, D-dimer, GLSZM_SZE, and zone size nonuniformity were significantly associated with shorter OS.

Conclusion:
Serum LDH, D-dimer, ferritin levels, and GLSZM_SZE of primary tumors may be used as prognostic biomarkers to identify patients with worse prognoses in high-risk neuroblastoma. GLSZM textural features showing higher tumor heterogeneity are significantly associated with shorter PFS and OS.
Effect of a Compassion Fatigue Resiliency Program on Nurse Managers' Professional Quality of Life, Stress, and Resilience
Authors: Pehlivan Sarıbudak Tuğba , Güner Perihan , Çepni Berrin 
Published: April 2023

Background:
Compassion fatigue, stress, and burnout have an adverse impact on nurse managers.

Purpose:
To evaluate the impact of a compassion fatigue resiliency program on nurse managers and to obtain their views of the program.

Methods:
This mixed-methods study was conducted with 16 nurse managers. The compassion fatigue resiliency program was implemented; compassion fatigue, compassion satisfaction, burnout, perceived stress, and resilience were assessed before and after implementation of the program.

Results:
The mean compassion fatigue and perceived stress scores of nurses decreased significantly after the intervention. Four themes were identified from qualitative analysis, including awareness, coping with stress, effective communication skills in team management, and recommendations.

Conclusions:
The current study shows the training program reduced nurse managers' compassion fatigue and stress and enabled nurse managers to improve their coping skills and awareness.
From the ER to the OR: Initial Evaluation of Primary Central Nervous System Lymphoma
Authors: Baskaran Archit B. , Dixit Karan S. , Sonabend Adam W. , Horbinski Craig M. , Abutalib Syed Ali , Lukas Rimas V. 
Published: April 2023

Background:
Primary central nervous system lymphoma (PCNSL) is a rare, often curable neoplasm, often initially presenting in acute care settings by nonneuroscience specialized physicians. Delays in the recognition of specific imaging findings, lack of appropriate specialist consultation, and urgent incorrect medication administration can delay necessary diagnosis and treatment.

Review Summary:
In this paper, the reader is moved quickly from the initial presentation to the diagnostic surgical intervention for PCNSL in a manner analogous to the experience of clinicians in the frontline setting. We review the clinical presentation of PCNSL, its radiographic features, the effect of prebiopsy steroids, and the role of a biopsy in the diagnosis. In addition, this paper revisits the role of surgical resection for PCNSL and investigational diagnostic studies for PCNSL.

Conclusion:
PCNSL is a rare tumor that is associated with high morbidity and mortality. However, with appropriate identification of clinical signs, symptoms, and key radiographic findings, the early suspicion of PCNSL can lead to steroid avoidance and timely biopsy for rapid administration of the potentially curative chemoimmunotherapy. Surgical resection presents the potential for improving outcomes for patients with PCNSL, however, this remains controversial. Further research into PCNSL presents the opportunity for better outcomes and longer livelihoods for patients.
Systemic Neoplastic Cryoglobulinemic Vasculitis Mimics Large Vessel Occlusion
Authors: Bisogno Antonio L. , Viaro Federica , Pieroni Alessio , Rinaldi Francesca , Corbetta Maurizio , Baracchini Claudio 
Published: April 2023

Introduction:
We describe a systemic neoplastic cryoglobulinemic vasculitis presenting as a large vessel occlusion (LVO) syndrome. We focus on a rare presentation of a rare condition.

Case Report:
A 68-year-old man was admitted to the Stroke Unit of Padova with a right middle cerebral artery syndrome. A cerebrovascular event was suspected and protocol for revascularization treatment was performed. Neuroimaging provided no evidence for infarcted tissue or medium-large vascular occlusion but hypothesized a vasculitic involvement of the small vessels of the right hemisphere. Further diagnostics demonstrated a microangiopathic involvement of the heart, kidneys, and lungs. Blood tests showed circulating cryoglobulins and further hematological investigation identified a chronic lymphatic leukemia-like lymphoproliferative disorder. High-dose steroid therapy improved the patient’s clinical status and no neurological symptoms remained at discharge.

Conclusion:
We discuss the clinical-radiologic presentation of a small vessel vasculitis that mimics an LVO stroke. This case focuses on the relevance of concomitant multiorgan manifestations in the hyper-acute evaluation of LVO stroke, suggesting the clinical neurologist should consider alternative etiologies as these could provide important clinical implications.
Burnout and Wellness Strategies Utilized by Academic Physiatry Programs: An Analysis and Perspective from the AAP Chairs Council
Authors: Steinberg David P. , Faurot Keturah R. , Thompson Karla L. , Alexander Joshua J. , Braza Diane W. , Cuccurullo Sara , Herrera Joseph , Sliwa James , Weiss Lyn 
Published: April 2023

ABSTRACT
Physiatrists are at elevated risk of burnout, a work-related exhaustion syndrome resulting from chronic stress associated with emotionally draining work demands. The high reported rate of burnout in Physical Medicine and Rehabilitation (PM&R) led the Association of Academic Physiatrists (AAP) Chair Council to convene a workgroup to address burnout among academic PM&R physicians. The Council recognizes that leaders of departments are accountable for all organizational stakeholders, including faculty, trainees, and staff. Department leaders are expected to understand and effectively manage the drivers of burnout among stakeholders. The workgroup identified several opportunities, including identifying and disseminating effective burnout mitigation across U.S. academic medical center PM&R programs. As a result, in 2019, a work group conducted a survey of U.S. academic PM&R program leaders to ascertain the use of strategies for reducing physician burnout. With the aim of identifying, educating, and advancing the development of effective interventions to address burnout among academic PM&R departments, the AAP Chair Council advocates for increased education and utilization of effective strategies aimed at promoting physician well-being across organizational levels (national, organizational, work unit, and individual).
Does spasticity correlate with motor impairment in the upper and lower limbs in ambulatory chronic stroke survivors?
Authors: Li Sheng , Ghuman Jaskiran , Gonzalez-Buonomo Javier , Huang Xinran , Malik Aila , Yozbatiran Nuray , Francisco Gerard E. , Wu Hulin , Frontera Walter R. 
Published: April 2023

Abstract

Objective
This study aimed to explore correlations between spasticity and motor impairments in the upper and lower limbs (UL and LL) in ambulatory chronic stroke survivors.

Design
We performed clinical assessments in 28 ambulatory chronic stroke survivors with spastic hemiplegia (female:12; male: 16; mean ages = 57.8 ± 11.8 yr; 76 ± 45 months after stroke).

Results
In the upper limb, spasticity index (SI_UL) and Fugl-Meyer Motor Assessment (FMA_UL) showed a significant correlation. SI_UL showed a significant negative correlation with handgrip strength of the affected side (r = -0.4, p = 0.035) while FMA_UL had a significant positive correlation (r = 0.77, p < 0.001). In the LL, no correlation was found between SI_LL and FMA_LL. There was a significant and high correlation between timed up and go test (TUG) and gait speed (r = 0.93, p < 0.001). Gait speed was positively correlated with SI_LL (r = 0.48, p = 0.01), and negatively correlated with FMA_LL (r = -0.57, p = 0.002). Age and time since stroke showed no association in analyses for both UL and LL.

Conclusions
Spasticity has a negative correlation on motor impairment in the upper limb but not in the lower limb. Motor impairment was significantly correlated with grip strength in the upper limb and gait performance in the lower limb of ambulatory stroke survivors.
Effectiveness of kinesio taping and night splinting along with physical therapy intervention on symptoms and functionality: A Double-Blind Randomized Controlled Trial for Moderate Carpal Tunnel Syndrome
Authors: ERASLAN Leyla , BALTACI Gul 
Published: April 2023

ABSTRACT

Objective
To compare the effects of kinesio taping (KT) and night splinting (NS) along with physical therapy intervention on symptoms in patients with moderate carpal tunnel syndrome (CTS) undergoing rehabilitation.

Design
In this double-blind, randomized controlled trial, forty-five patients with moderate CTS were included and randomly assigned to three groups: KT Group (n = 15), NS Group (n = 15), and control group (CG) (n = 15). All patients received 20 physical therapy intervention sessions. The primary outcome was self-reported disability status measured by the Boston Carpal Tunnel Questionnaire, and secondary outcomes were pain and paresthesia (rest, activity, and night) measured by the Numeric Rating Scale. Outcomes were recorded at baseline and four weeks.

Results
All patients showed clinically meaningful improvements for all outcome measures over time (p < 0.05). The intergroup analysis revealed that the KT group demonstrated better results in all measures than the NS (p < 0.05) except for pain during activity (p = 0.054), at night (p = 0.191), and paresthesia at rest (p = 0.575). Additionally, the KT group showed better outcomes than the CG (p < 0.05) except for the activity pain (p = 0.022). However, there were negligible differences between NS and CG (p > 0.05).

Conclusion
Kinesio taping in combination with physical therapy intervention is more effective than NS in combination with physical therapy intervention or physical therapy intervention alone and may be recommended.
The profile of athletes with a vision impairment: Exploring demographics and ocular pathologies of athletes in three Paralympic sports
Authors: Zenk Franziska , Willmott Ashley G. B. , Fortin-Guichard Daniel , Austick Kizzy , Mann David L. , Winckler Ciro , Allen Peter M. 
Published: April 2023

Abstract

Objective
This study aimed to explore the profile of athletes with a vision impairment (VI) who compete in three Paralympic sports (goalball, VI judo and blind football).

Design
Descriptive and association analyses of the VI athletes’ profile were conducted.

Results
The typical athlete profile was a male (65.1%), aged 26-34 years (39.7%), from Europe (38.8%), representing a country with a high-income (46.1%) and was diagnosed with a retinal-related ocular pathology (38.9%). In all three sports, the ages of the athletes were similar. In goalball, most athletes were from Europe, represented countries with a high-income and were diagnosed with retinal-, globe-, or neurological-related pathologies. In VI judo, the majority of athletes were from Asia, represented countries with an upper-middle-income and were diagnosed with retinal-, global-, or neurological-related pathologies. In blind football, most athletes were from Europe, represented countries with an upper-middle-income, and were diagnosed with retinal-, neurological-related ocular pathologies, or glaucoma.

Conclusions
The homogeneity of the athletes’ profile suggests that an effort is needed to target other parts of the VI population to take part in VI sports. Differences in the athletes’ profiles across the sports provides information that may be useful for sport-specific talent identification.
Discontinuation and nonpublication analysis of chronic pain randomized controlled trials
Authors: Jacobsen Samuel M. , Moore Ty , Douglas Alexander , Lester Drew , Johnson Austin L. , Vassar Matt 
Published: April 2023

Abstract

Introduction:
The primary objective of this cross-sectional analysis is to evaluate rates of discontinuation and nonpublication of Randomized controlled trials (RCTs) of therapeutic interventions to treat chronic pain.

Methods:
Using ClinicalTrials.gov, a sample was obtained which included clinical trials pertaining to chronic pain. Trials were analyzed for publication status and completion status of each trial. If information was unavailable on the trial registry database, or could not be allocated through a systematic search, the corresponding trialist was contacted and data points were gathered.

Results:
In our final analysis of the 408 RCTs, we found that 281 (68.9%) were published in a peer-reviewed journal and 127 (31.1%) were unpublished trials. Of 112 discontinued trials, 59 (52.7%) reached publication. In addition, 221 of 296 completed trials (74.7%) were published, and 75 (25.3%) remained unpublished after trial completion. The most common listed reason for trial discontinuation was administrative recommendations (41 of 71 trials [57.7%]), while not receiving an email reply to our standardized email from the corresponding trialist was the most common result for trial nonpublication (49 of 88 trials [55.7%]). Clinical trials funded by nonindustry sponsors were more likely to reach publication than industry-funded clinical trials (unadjusted odds ratio 1.86 [95% CI, 1.18–2.95]; adjusted odds ratio 3.01 [95% CI, 1.76–5.14]).

Conclusion:
The rate of discontinuation of RCTs involving patients with chronic pain is concerning. Chronic pain affects many patients; thus, the importance of having quality data from clinical trials cannot be overstated. Our study indicates that chronic pain RCTs are frequently discontinued and their findings often go unpublished — all of which could provide crucial information to providers and patients regarding the treatment of chronic pain. We offer suggestions to enhance chronic pain RCT completion, thereby reducing the waste of resources in chronic pain research.
Magnetic Resonance Fingerprinting
Authors: Gaur Sonia , Panda Ananya , Fajardo Jesus E. , Hamilton Jesse , Jiang Yun , Gulani Vikas 
Published: April 2023

Abstract
Magnetic resonance fingerprinting (MRF) is an approach to quantitative magnetic resonance imaging that allows for efficient simultaneous measurements of multiple tissue properties, which are then used to create accurate and reproducible quantitative maps of these properties. As the technique has gained popularity, the extent of preclinical and clinical applications has vastly increased. The goal of this review is to provide an overview of currently investigated preclinical and clinical applications of MRF, as well as future directions. Topics covered include MRF in neuroimaging, neurovascular, prostate, liver, kidney, breast, abdominal quantitative imaging, cardiac, and musculoskeletal applications.
Yield of Staging Laparoscopy for Pancreatic Cancer in the Modern Era: Analysis of Over 1000 Consecutive Patients
Authors: Gudmundsdottir Hallbera , Yonkus Jennifer A , Alva-Ruiz Roberto , Kendrick Michael L , Smoot Rory L , Warner Susanne G , Starlinger Patrick , Thiels Cornelius A , Nagorney David M , Cleary Sean P , Grotz Travis E , Truty Mark J 
Published: April 2023

Background:
Accurate staging prior to resection of pancreatic ductal adenocarcinoma (PDAC) is imperative to avoid unnecessary operative morbidity and oncologic futility in patients with occult intraabdominal distant metastases. We aimed to determine the diagnostic yield of staging laparoscopy (SL) and identify factors associated with increased risk of positive laparoscopy (PL) in the modern era.

Study Design:
Patients with radiographically localized PDAC who underwent SL 2017-2021 were retrospectively reviewed. The yield of SL was defined as the proportion of patients with PL, including gross metastases and/or positive peritoneal cytology. Factors associated with PL were assessed using univariate analysis and multivariable logistic regression.

Results:
Of 1004 patients who underwent SL, 180 (18%) had PL due to gross metastases (n=140) and/or positive cytology (n=96). Patients who had neoadjuvant chemotherapy prior to laparoscopy had lower rates of PL (14% versus 22%, p=0.002). When the analysis was restricted to chemo-naive patients who had concurrent peritoneal lavage performed, 95 of 419 patients (23%) had PL. In multivariable analysis, PL was associated with younger (<60) age, indeterminate extrapancreatic lesions on preoperative imaging, body/tail tumor location, larger tumor size, and elevated serum CA 19-9 (all p<0.05). Among patients with no indeterminate extrapancreatic lesions on preoperative imaging, the rate of PL ranged from 1.6% in patients with no risk factors to 42% in young patients with large body/tail tumors and elevated serum CA 19-9.

Conclusion:
The rate of PL in patients with PDAC remains high in the modern era. SL with peritoneal lavage should be considered for the majority of patients prior to resection, specifically those with high-risk features, and ideally prior to neoadjuvant chemotherapy.
Longitudinal study of humoral immunity against SARS-CoV-2 of health professionals in Brazil: the impact of booster dose and reinfection on antibody dynamics
Authors: Franco-Luiz Ana Paula Moreira , Fernandes Nubia Monteiro Gonçalves Soares , de Souza Silva Thais Bárbara , de Oliveira Santos Bernardes Wilma Patrícia , Westin Mateus Rodrigues , Santos Thais Garcia , da Rocha Fernandes Gabriel , Simões Taynãna César , e Silva Eduardo Fernandes , Gava Sandra Grossi , Alves Breno Magalhães , de Carvalho Melo Mariana , da Silva-Pereira Rosiane A. , Alves Pedro Augusto , Fonseca Cristina Toscano 
Published: April 2023

AbstractThe pandemic caused by SARS-CoV-2 has had a major impact on health systems. Vaccines have been shown to be effective in improving the clinical outcome of COVID-19, but they are not able to fully prevent infection and reinfection, especially that caused by new variants. Here, we tracked for 450 days the humoral immune response and reinfection in 52 healthcare workers from Brazil. Infection and reinfection were confirmed by RT-qPCR, while IgM and IgG antibody levels were monitored by rapid test. Of the 52 participants, 19 (36%) got reinfected during the follow-up period, all presenting mild symptoms. For all participants, IgM levels dropped sharply, with over 47% of them becoming seronegative by the 60th day. For IgG, 90% of the participants became seropositive within the first 30 days of follow-up. IgG antibodies also dropped after this period reaching the lowest level on day 270 (68.5±72.3, p<0.0001). Booster dose and reinfection increased the levels of both antibodies, with the interaction between them resulting in an increase in IgG levels of 130.3 units. Overall, our data indicate that acquired humoral immunity declines over time and suggests that IgM and IgG antibody levels are not associated with the prevention of reinfection.ImportanceThis prospective observational study monitored the kinetics of humoral response and the occurrence of reinfection in a population of healthcare workers (HCW) who got COVID-19 over a period of 450 days. During the study period, HCW was a prioritized in COVID-19 vaccination campaign, several SARS-CoV-2 variants of concern circulated in the country, and nineteen participants of the study got reinfected. So, we were able to investigate the duration of humoral response against COVID-19, the impact of vaccination boost and reinfection in the production of anti-SARS-CoV-2 antibodies, and the associating of this antibodies with protection against reinfection. These information are important to support health managers in defining COVID19 surveillance and control actions.
euka: Robust detection of eukaryotic taxa from modern and ancient environmental DNA using pangenomic reference graphs
Authors: Vogel Nicola Alexandra , Rubin Joshua Daniel , Swartz Mikkel , Vlieghe Juliette , Sackett Peter Wad , Pedersen Anders Gorm , Pedersen Mikkel Winther , Renaud Gabriel 
Published: April 2023

Abstract1. Ancient environmental DNA (eDNA) is a crucial source of in-formation for past environmental reconstruction. However, the com-putational analysis of ancient eDNA involves not only the inherited challenges of ancient DNA (aDNA) but also the typical difficulties of eDNA samples, such as taxonomic identification and abundance esti-mation of identified taxonomic groups. Current methods for ancient eDNA fall into those that only perform mapping followed by taxo-nomic identification and those that purport to do abundance estima-tion. The former leaves abundance estimates to users, while methods for the latter are not designed for large metagenomic datasets and are often imprecise and challenging to use.2. Here, we introduce euka, a tool designed for rapid and accurate characterisation of ancient eDNA samples. We use a taxonomy-based pangenome graph of reference genomes for robustly assigning DNA sequences and use a maximum-likelihood framework for abundance estimation. At the present time, our database is restricted to mito-chondrial genomes of tetrapods and arthropods but can be expanded in future versions.3. We find euka to outperform current taxonomic profiling tools as well as their abundance estimates. Crucially, we show that regardless of the filtering threshold set by existing methods, euka demonstrates higher accuracy. Furthermore, our approach is robust to sparse data, which is idiosyncratic of ancient eDNA, detecting a taxon with an average of fifty reads aligning. We also show that euka is consistent with competing tools on empirical samples and about ten times faster than current quantification tools.4. euka’s features are fine-tuned to deal with the challenges of ancient eDNA, making it a simple-to-use, all-in-one tool. It is available on GitHub:https://github.com/grenaud/vgan. euka enables re-searchers to quickly assess and characterise their sample, thus allowing it to be used as a routine screening tool for ancient eDNA.