bluuebunny/crossref_metadata_2025_split huggingface dataset:
Closing the gap between science and management of cold‐water refuges in rivers and streams
Authors: Mejia Francine H. , Ouellet Valerie , Briggs Martin A. , Carlson Stephanie M. , Casas‐Mulet Roser , Chapman Mollie , Collins Mathias J. , Dugdale Stephen J. , Ebersole Joseph L. , Frechette Danielle M. , Fullerton Aimee H. , Gillis Carole‐Anne , Johnson Zachary C. , Kelleher Christa , Kurylyk Barret L. , Lave Rebecca , Letcher Benjamin H. , Myrvold Knut M. , Nadeau Tracie‐Lynn , Neville Helen , Piégay Herve , Smith Kathryn A. , Tonolla Diego , Torgersen Christian E. 
Published: July 2023

AbstractHuman activities and climate change threaten coldwater organisms in freshwater ecosystems by causing rivers and streams to warm, increasing the intensity and frequency of warm temperature events, and reducing thermal heterogeneity. Cold‐water refuges are discrete patches of relatively cool water that are used by coldwater organisms for thermal relief and short‐term survival. Globally, cohesive management approaches are needed that consider interlinked physical, biological, and social factors of cold‐water refuges. We review current understanding of cold‐water refuges, identify gaps between science and management, and evaluate policies aimed at protecting thermally sensitive species. Existing policies include designating cold‐water habitats, restricting fishing during warm periods, and implementing threshold temperature standards or guidelines. However, these policies are rare and uncoordinated across spatial scales and often do not consider input from Indigenous peoples. We propose that cold‐water refuges be managed as distinct operational landscape units, which provide a social and ecological context that is relevant at the watershed scale. These operational landscape units provide the foundation for an integrated framework that links science and management by (1) mapping and characterizing cold‐water refuges to prioritize management and conservation actions, (2) leveraging existing and new policies, (3) improving coordination across jurisdictions, and (4) implementing adaptive management practices across scales. Our findings show that while there are many opportunities for scientific advancement, the current state of the sciences is sufficient to inform policy and management. Our proposed framework provides a path forward for managing and protecting cold‐water refuges using existing and new policies to protect coldwater organisms in the face of global change.
Different Feathers Embedding Together: Integrating Diversity and Organizational Embeddedness
Authors: Ghosh Debjani , Gonzalez Jorge A. , Sekiguchi Tomoki 
Published: July 2023

AbstractDespite the increase of demographic diversity in organizational environments, little is known about how and why employees from distinct demographic backgrounds (e.g., gender, race, and/or ethnicity) become embedded in their work organizations, which is a reason why employees stay and perform in their jobs. To address this research gap, we integrate job embeddedness and social identification/self‐categorization theories and draw from critical diversity studies to theorize on the effects of varying degrees of demographic diversity on the organizational embeddedness of diverse talent. Specifically, we theorize on how monolithic, pluralistic, and multicultural organizational stages, reflecting distinct degrees of heterogeneity, structural integration, and inclusion, affect the process by which employees from both dominant and marginalized social groups develop organizational embeddedness dimensions – links, fit, and sacrifice – with a distinct nature, order, degree, and speed. We further theorize how inclusive leadership can promote organizational embeddedness of employees from all social groups in the three organizational demography stages.
Laparoscopic cryptorchidectomy using a resorbable self‐locking loop device in dorsally recumbent horses
Authors: Bonomelli Natacha , Höglund Odd Viking , Bonilla Alvaro G. 
Published: July 2023

AbstractObjectiveTo report the use and feasibility of a self‐locking resorbable loop device for cryptorchidectomy.Study designClinical prospective study.PopulationTwenty horses.MethodsHorses suspected to have an abdominal testicle/s after admission work‐up were enrolled. Horses were anesthetized in dorsal recumbency and a standard laparoscopic technique was performed. The looped device was inserted into the abdomen, glided around the testis/cord and tightened. Then, the spermatic cord was transected prior testis removal. Surgical procedure details and remarks, perioperative complications and total surgical time were recorded. Short‐ (>3 weeks) and long‐term (>6 months) follow‐ups were obtained by telephone questionnaire.ResultsMedian total surgical time was 67 min (range: 43–189 min) and significantly shortened after the first four horses. The loop device was easily glided around 13/20 abdominal testes and required more time and technical skills around larger testes (≥3 years). Excellent intraoperative hemostasis was achieved in 17 horses. Three horses demonstrated mild intraoperative bleeding that required retightening, device replacement or adding a second device, respectively. Three horses developed mild postoperative hemoabdomen identified ultrasonographically and were successfully managed medically. Follow‐up revealed no significant complications related to the procedure. One horse was euthanized for colic 4 months after surgery and one died of hemolytic shock 17 months postoperatively.ConclusionThis device represents another method to perform equine cryptorchidectomy that requires minimal training and laparoscopic expertise but demands knowledge of the device and application to prevent complications.Clinical significanceLaparoscopic cryptorchidectomy using this device is an alternative technique for horses <3 years.
A comment on the paper “The structural, elastic, electronic and optical properties of MgCu under pressure: A first-principles study”
Authors: Anand K. , Rajesh K. , Sharma V. S. 
Published: July 2023

Rahman et al. [International Journal of Mod. Phys. B 30, 1650199 (2016)] found that MgCu intermetallic compound with CsCl-type (B2) structure becomes unstable under pressure at about 15[Formula: see text]GPa. This prediction has been made using an elastic instability condition for second-order elastic constants given by Born. They determined the elastic constants using Hooke’s law for the linear stress–strain relationship which does not hold good at high pressures. It has been shown here that the values of elastic constants for MgCu at high pressures determined by Rahman et al. are not consistent with the values of bulk modulus computed from the Birch–Murnaghan equation of state (BM-EOS). We have used the Tallon formulation based on the thermodynamics of elastic deformation to estimate elastic constants which yields results for the bulk modulus of MgCu at different pressures in good agreement with those determined from the BM-EOS. It has been found that MgCu remains stable up to about 20 GPa which is significantly higher than the limit of elastic stability predicted by Rahman et al.
Supplementary Figure 8 from Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial–mesenchymal Transition in Aggressive Variant Prostate Cancers
Authors: Mitra Ghosh Taraswi , Mazumder Suman , Davis Joshua , Yadav Jyoti , Akinpelu Ayuba , Alnaim Ahmed , Kumar Harish , Waliagha Razan , Church Bird Allison E. , Rais-Bahrami Soroush , Bird R. Curtis , Mistriotis Panagiotis , Mishra Amarjit , Yates Clayton C. , Mitra Amit K. , Arnold Robert D. 
Published: July 2023

<p>Supplementary Fig. 8 shows Flow Cytometry; Prostate cancer cell lines stained with stemness markers (CD44, CD133 and CD44/133) to determine the percent of CD44+, CD133+ and double positive cells among PCa subtypes. Treatments with CONV-TOPO, METRO-TOPO and CONV-DTX+METRO-TOPO reduced stemness. METRO-TOPO reduced CD44+ cells to a greater extent compared to CONV-TOPO and CONV-DTX treatments, whereas combination treatment with CONV-DTX+METRO-TOPO reduced stemness (CD44+ cells) the most in ARHigh/mCRPC/NEPC. A) PC-3M, B) DU145 cell lines.</p>
Confidence is predicted by pre- and post-choice decision signal dynamics
Authors: Grogan John P. , Rys Wouter , Kelly Simon P. , O’Connell Redmond G. 
Published: July 2023

Abstract
It is well established that one’s confidence in a choice can be influenced by new evidence encountered after commitment has been reached, but the processes through which post-choice evidence is sampled remain unclear. To investigate this, we traced the pre- and post-choice dynamics of electrophysiological signatures of evidence accumulation (Centro-parietal Positivity, CPP) and motor preparation (mu/beta band) to determine their sensitivity to participants’ confidence in their perceptual discriminations. Pre-choice CPP amplitudes scaled with confidence both when confidence was reported simultaneously with choice, and when reported 1 second after the initial direction decision with no intervening evidence. When additional evidence was presented during the post-choice delay period, the CPP exhibited sustained activation after the initial choice, with a more prolonged build-up on trials with lower certainty in the alternative that was finally endorsed, irrespective of whether this entailed a change-of-mind from the initial choice or not. Further investigation established that this pattern was accompanied by later lateralisation of motor preparation signals toward the ultimately chosen response and slower confidence reports when participants indicated low certainty in this response. These observations are consistent with certainty-dependent stopping theories according to which post-choice evidence accumulation ceases when a criterion level of certainty in a choice alternative has been reached, but continues otherwise. Our findings have implications for current models of choice confidence, and predictions they may make about EEG signatures.
Re-Examining the Industry Experience–Venture Survival Relationship
Authors: Guenther Agnes , Shaver J. Myles 
Published: July 2023

We re-examine the finding that new ventures employing individuals with industry experience have survival advantages and conclude that it is unlikely a reflection of the underlying theoretical mechanism advanced in the literature—individuals applying their industry-specific knowledge. We come to this conclusion by leveraging detailed linked employer-employee data from Denmark and conducting an inferred pattern analysis where we analyze several empirical relationships that we interpret in tandem. After replicating the industry experience–venture survival relationship, we identify several empirical puzzles if the underlying causal mechanism is leveraging industry-specific knowledge. In light of these puzzles, analysis of their robustness, and initial exploratory empirical investigations, we propose that other human capital characteristics that correlate with industry experience (i.e., overall experience and wages) are better explanatory factors. The analysis illustrates how the data-grounded steps of an inferred pattern analysis can guide future theoretical development and empirical investigations to identify the causal mechanism underlying a well-established empirical relationship in the literature. Supplemental Material: The online appendix is available at https://doi.org/10.1287/stsc.2022.0033 .
Graded weakly 1-absorbing primary ideals
Authors: Bataineh Malik , Abu-Dawwas Rashid 
Published: July 2023

Abstract
Let

G

G

be a group and

R

R

be a

G

G

-graded commutative ring with nonzero unity 1. In this article, we introduce the concept of graded weakly 1-absorbing primary ideals which is a generalization of graded 1-absorbing primary ideal. A proper graded ideal

P

P

of

R

R

is said to be a graded weakly 1-absorbing primary ideal of

R

R

if whenever nonunit elements

x
,
y
,
z
∈
h

(

R

)

x,y,z\in h\left(R)

such that

0
≠
x
y
z
∈
P

0\ne xyz\in P

, then

x
y
∈
P

xy\in P

or

z

n

∈
P

{z}^{n}\in P

, for some

n
∈
N

n\in {\mathbb{N}}

. Several properties of graded weakly 1-absorbing primary ideals are investigated.
Effect of a CrossMab cotargeting CD20 and HLA-DR in non-Hodgkin lymphoma
Authors: Zeng Jing , Chen Yalin , Zhang Tingting , Wang Jinjing , Yang Yan , Fang Yi 
Published: July 2023

Abstract

Objectives
To evaluate the anti-tumor activities of CD20/HLA-DR CrossmabCH1-CL through cell and animal models.

Methods
Based on “knobs-into-holes” and “crossover” technology, CrossMab, targeting CD20 and HLA-DR, was constructed. A binding assay and a competitive inhibition assay were performed to confirm its specificity. The effects of CrossMab on antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity were measured. Cell apoptosis, lysosome-mediated cell death, and lysosomal permeability were quantified. In addition, the effects of CrossMab on peripheral blood leukocytes were tested. The pharmacokinetics were determined with a noncompartmental analysis model. Human malignant lymphoma xenograft models in CB17-SCID mice were established for an in-vivo efficacy study.

Results
The antitumor activities of CrossMab were shown both in vitro and in vivo. CrossMab exhibited strong binding to CD20 and HLA-DR at the same time in Raji cells. CrossMab also demonstrated antilymphoma effects by inducing antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. Furthermore, CrossMab altered the lysosomal membrane permeability. The toxicity of CrossMab on normal peripheral blood lymphocytes (PBLs) was specific to B cells. A mouse xenograft model demonstrated the antitumor activities of CrossMab in vivo.

Conclusions
CrossMab exhibited an enhanced antigen recognition ability and antitumor activities in lymphoma without evident toxicity. CrossMab could be an effective immunotherapeutic strategy for non-Hodgkin lymphoma.
An Analysis of Trauma Team Activations at a South African Level One Trauma Centre
Authors: Goldsteini Lara Nicole , Beskyd Peter , Wells Mike 
Published: July 2023

ABSTRACT

Introduction: South Africa has a high prevalence of trauma causing a significant healthcare and financial burden. Various scoring systems have been developed to guide trauma team activation (TTA). To date, however, there are no standardised criteria for TTA. The aim of this preliminary study was to analyse the practice of clinical judgement TTA when compared to the American College of Surgeons Committee on Trauma (ACS-COT) TTA guideline and the Loma Linda Rule for TTA.

Methods: This was a retrospective analysis of trauma registry data over a one-year period from a Level 1 trauma centre in South Africa.

Results: There were 9207 trauma patients that presented to the Emergency Department during the 1-year study period. The prevalence of trauma team activation by clinical judgement was 9.4%. Only 407 patients (48%) of the clinical judgement TTAs fulfilled the ACS-COT guidelines for TTA. Using the Loma Linda Rule, 456 patients (53.8%) of the clinical judgement TTAs fulfilled TTA criteria. Despite the over-triage by the clinical judgement TTA, almost two-thirds of the TTA patients were admitted to the intensive care or high care units.

Conclusions: This preliminary study showed that TTA using healthcare provider clinical judgement resulted in trauma team over-activation when compared to the ACS-COT guideline and the Loma Linda Rule. Over-activation of the trauma team consumes valuable resources and potentially endangers those patients who actually need TTA and cannot receive it. Implementation of a standardised TTA tool could potentially aid in the optimisation of patient care and appropriate resource utilisation.
Blockade of TGF-β signalling alleviates human adipose stem cell senescence induced by native ECM in obesity visceral white adipose tissue
Authors: han xueya , Li Weihong , He Xu , Lu Xin , Zhang Yu , Li Yaqiong , Bi Guoyun , Ma Xuqing , Huang Xiaowu , Bai Rixing , Zhang Haiyan 
Published: July 2023

Abstract
Background
Abdominal obesity is appreciated as a major player in insulin resistance and metabolically dysfunctional adipose tissue. Inappropriate extracellular matrix (ECM) remodeling and functional alterations in human adipose stromal/stem cells (hASCs) have been linked with visceral white adipose tissue (vWAT) dysfunction in obesity. Understanding the interactions between hASCs and the native ECM environment in obese vWAT is required for the development of future therapeutic approaches for obesity-associated metabolic complications.
Methods
The phenotypes and transcriptome properties of hASCs from the vWAT of obese patients and lean donors were assessed. The hASC-derived matrix from vWAT of obese or lean patients was generated in vitro using a decellularized method. The topography and the major components of the hASC-derived matrix were determined. The effects of the obese hASC-derived matrix on cell senescence and mitochondrial function were further determined.
Results
We showed that hASCs derived from the vWAT of obese patients exhibited senescence and were accompanied by the increased production of ECM. The matrix secreted by obese hASCs formed a fibrillar suprastructure with an abundance of fibronectin, type I collagen, and transforming growth factor beta 1 (TGF-β1), which resembles the native matrix microenvironment of hASCs in visceral WAT derived from obese patients. Furthermore, the obese hASC-derived matrix promoted lean hASC ageing and induced mitochondrial dysfunction compared to the lean hASC-derived matrix. Blockade of TGF-β1 signalling using a TGF-β1 neutralizing antibody alleviated the lean hASC senescence and mitochondrial dysfunction induced by the obese hASC-derived matrix.
Conclusions
Native ECM in obesity vWAT initiates hASC senescence through TGF-β1-mediated mitochondrial dysfunction. These data provide a key mechanism for understanding the importance of cell-ECM interactions in hASCs senescence in obesity.
Polygenic risk alters the penetrance of monogenic kidney disease
Authors: Kiryluk Krzysztof , Khan Atlas , Shang Ning , Nestor Jordan , Weng Chunhua , Hripcsak George , Harris Peter , Gharavi Ali 
Published: July 2023

Abstract
Importance
Chronic kidney disease (CKD) is a genetically complex disease determined by an interplay of monogenic, polygenic, and environmental risks. The most common forms of monogenic kidney disorders include autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in the PKD1 or PKD2 genes, and COL4A-associated nephropathy (COL4A-AN), caused by mutations in COL4A3, COL4A4, or COL4A5 genes. These disorders have incomplete penetrance and variable expressivity. It is presently unknown if some of the variability in penetrance can be attributed to polygenic factors.
Objective
Our objectives were to investigate the interplay of polygenic and monogenic risk of kidney disease and to test the utility of polygenic risk scores for risk stratification in ADPKD and COL4-AN.
Design
We combined exome/genome sequencing, SNP micro-array, and electronic health record data from the UK Biobank (N = 469,835 participants) and the All of Us (N = 98,622 participants) datasets to test the effects of the genome-wide polygenic score (GPS) for CKD in ADPKD and COL4-AN variant carriers defined by strict variant classification criteria. We used the eMERGE-III electronic CKD phenotype to define cases (estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2 or kidney failure) and controls (eGFR > 90 mL/min/1.73m2 in the absence of kidney disease diagnoses). The GPS was tested as a predictor of CKD in qualifying variant carriers and non-carriers using logistic regression after adjustment for age, sex, diabetes, and genetic ancestry.
Results
The GPS was predictive of CKD in ADPKD variant carriers (ORmeta=2.28 per SD, 95%CI: 1.55–3.37, P = 2.6E-05) as well as non-carriers (ORmeta=1.72 per SD, 95% CI = 1.69–1.76, P < E-300) independent of age, sex, diabetes, and genetic ancestry. Compared to the middle tertile of the GPS distribution for non-carriers, ADPKD variant carriers in the top tertile had a 54-fold increased risk of CKD, while ADPKD variant carriers in the bottom tertile had only a 3-fold increased risk of CKD. Similarly, the GPS was predictive of CKD in both COL4-AN carriers (ORmeta=1.78, 95% CI = 1.22–2.58, P = 2.38E-03) and non-carriers (ORmeta=1.70, 95%CI: 1.68–1.73 P < E-300). The carriers in the top GPS tertile had a 2.5-fold higher risk of CKD while the risk for carriers in the bottom GPS tertile was not different from the average population risk.
Conclusions and Relevance
Variable penetrance of kidney disease in ADPKD and COL4-AN is partially explained by the differences in polygenic risk profiles. Accounting for polygenic factors improves risk stratification in monogenic kidney disease and may have clinical implications for genetic counseling.
Distortion correction using topup algorithm by single k- space (TASK) for echo planar imaging
Authors: Hwang Seon-Ha , Lee Hyun-Soo , Choi Seung Hong , Park Sung-Hong 
Published: July 2023

Abstract
Distortion of echo planar imaging (EPI) can be corrected using B0 field maps, which can be acquired with the topup algorithm that requires two EPI images with opposite distortions. In this study, we propose a new algorithm, termed Topup Algorithm by Single K-space (TASK), to generate two input images from a single k-space for the topup algorithm to correct EPI distortions. The centric EPI contains the opposite phase-encoding polarities in one k-space, which can be divided into two halves with opposite distortions. Therefore, two inputs could be extracted by dividing the k-space into halves and processing them using the proposed procedure including an iterative procedure of automatic brain masking and uniformity correction. The efficiency of TASK was evaluated using 3D EPI. Quantitative evaluations showed that TASK corrected EPI distortion in a similar level to the traditional methods. The estimated field maps from the conventional topup and TASK showed high correlation (\(r=0.8048\pm 0.0534\)). An ablation study showed the validity of every suggested step. Furthermore, it was confirmed that TASK was effective for distortion correction of two-shot centric EPI as well, demonstrating its wider applicability. In conclusion, TASK can correct EPI distortions by its own single k-space information with no additional scan.
Lineament depth deduction using geomorphometry and 3d-Euler solution
Authors: koundi Mourad El , DHAOUI Mohamed , GHALI Abdessalem EL 
Published: July 2023

Abstract
In this paper, we present a novel method for determining the depth of lineaments using satellite gravity data, which we test in the Sahel of Sfax area (eastern Tunisia). This region has a relatively flat topography with few significant discontinuities at the surface.
As a first step, we used morphometric indices such as slope, aspect, and hydrographic network, calculated from SRTM-DEM, to generate separate lineament maps. We then combined these lineaments into a synthetic lineament map, which showed a high level of agreement with the Bouguer anomaly map derived from satellite gravity data and with previous studies that used geophysical data (seismic and gravity). We also validated the lineament map using field data.
By fusing these lineaments with the 3D Euler solution map, we were able to deduce the depth classification of the lineaments. Our results demonstrate the effectiveness of our proposed method in estimating the depth of lineaments and its potential to provide valuable insights into the subsurface geology of an area. This method can be a useful tool for mineral exploration, hydrocarbon exploration, and geohazard assessments.