bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Landslide susceptibility mapping by Frequency Ratio and Fuzzy logic approach, a case study of Mogods and Hedil (Northern Tunisia)
Authors: KLAI Adel , KATLANE Rim , HADDAD Romdhane , RABIA Mohamed Chedly 
Published: June 2023

Abstract
The aim of this study is to produce a landslide susceptibility map in Mogods and Hedil using the fuzzy logic method. To increase the objectivity of the approach, the fuzzy membership was calculated using the frequency ratio (FR). Nine factors were considered for landslide control, including slope, aspect, plan curvature, profil curvature, distance from faults, distance from rivers, land use, precipitation, and lithology. The frequency ratio was used to calculate the fuzziness of each factor, and these results were then applied to the fuzzy operators to produce the landslide susceptibility map. The selection of the susceptibility map closest to reality was based on the spatial distribution of landslides in each susceptibility class of each fuzzy operator and on the application of the receiver operating curve (ROC). The results of the Area Under Curve (AUC) analysis show that the gamma operator (0.90) provided the most accurate prediction of the landslide susceptibility map, as indicated by the prediction accuracy of the model (0.766). The study area was classified into four classes using Jenks natural fracture classification method: low susceptibility zone, moderate susceptibility zone, high susceptibility zone and very high susceptibility zone. The use of the fuzzy gamma operator for landslide susceptibility mapping gave a very satisfactory result with a reliability rate of 76.6%.
A randomised trial of topical polaprezinc to prevent oral mucositis in patients undergoing haematopoietic stem cell transplantation (ToPaZ Study)
Authors: Nakagaki Midori , Kennedy Glen A , Gavin Nicole C , Butler Jason , Clavarino Alexandra , Whitfield Karen 
Published: June 2023

Abstract
Purpose
Oral mucositis (OM) is a common complication in haematopoietic stem cell transplantation (HSCT). Polaprezinc, an anti-ulcer drug, has been shown to be effective to prevent OM in several studies when administered topically and systemically. This study aimed to evaluate the effectiveness of topical polaprezinc in patients undergoing HSCT.
Methods
This was an open-label randomised clinical trial comparing polaprezinc and sodium bicarbonate mouthwashes for the prevention of severe OM in HSCT patients. Adult patients who received conditioning regimens at moderate to high risk of developing OM were included. The primary endpoint was the incidence of severe (WHO grade 3–4) OM. The secondary endpoints included duration of grade 3–4 OM, incidence and duration of Grade 2–4 OM, patient-reported pain and functional limitations.
Results
In total, 108 patients (55 test arm, 53 control arm) were randomised. There was no difference in the incidence of grade 3 to 4 OM (35% test arm versus 36% control arm). The secondary endpoints were not significantly different. In both arms, patients reported more throat pain compared to mouth pain.
Conclusions
Topical polaprezinc had no effect in prevention of OM in HSCT patients. Further research is required to evaluate the effects of systemic polaprezinc. The OM assessment tool needs to be reviewed as throat mucositis was a main issue in this study.
Trial registration
ACTRN12320001188921
Design and application of a rate-limiting and precise external cerebrospinal fluid drainage device in patients with carcinomatous meningitis
Authors: Chen Lu , Zhang Yuanzhen , Li Jie , Chen Xi , Chen Li , Xie Fangwei , Chen Xiuping , Peng Yonghai , Chen Siyu , Chen Guangming , Nie Xiaojing 
Published: June 2023

Abstract
Objective
To develop a rate-limiting and precise external cerebrospinal fluid drainage device for intracranial decompression in carcinomatous Meningitis (CM).
Methods
The device consists of an intrathecal drug delivery system (IDDS), a drainage pathway and a pressure measurement pathway. The cerebrospinal fluid pressure (CSF) is measured using the pressure difference between the subarachnoid space and the atmosphere, and the active directional drainage is achieved with the driving force of the infusion pump, and the cerebrospinal fluid pressure is monitored at the same time as the drainage.
Results
Changed the passive, intermittent and rough drainage of conventional external CSF drainage device to achieve active, continuous, rate-limiting and precise drainage. It was applied to a patient with advanced systemic multiple metastases of gastric indolent cell carcinoma complicated with CM, and the clinical symptoms were well controlled and the intracranial pressure was smoothly controlled for 99 days, without common complications such as high intracranial pressure due to insufficient drainage and low intracranial pressure due to excessive drainage, and without infection, poor drainage and line blockage.
Conclusion
The device is safe, effective, precise and controllable for drainage of CSF, with good effectiveness, practicality and safety, and is worth promoting.
Analysis of clinical efficacy and safety of hand-sewn anastomosis for the digestive tract with Da Vinci robot in rectal cancer surgery
Authors: feng zhen , Sun Zhiwei , Zhang Qianshi , Ren Shuangyi 
Published: June 2023

Abstract
Purpose
The study aimed to analyze the clinical efficacy and safety of hand-sewn anastomosis for the digestive tract with Da Vinci robot in rectal cancer surgery.
Materials and methods
A retrospective study was conducted to collect the clinical data from 27 patients who underwent Da Vinci robotic rectal cancer radical surgery in the department of gastrointestinal surgery at the Second Affiliated Hospital of Dalian Medical University from August 2019 to February 2022. All patients received a manual suture for digestive tract reconstruction. After the posterior wall was sutured, the anterior wall was sutured continuously. Finally, a prilling thread was used to sew the junction of the front and rear walls. Perioperative indexes and complications were recorded.
Results
All 27 patients successfully underwent the operation. Neither conversion to laparotomy nor perioperative death occurred. The operation time and intraoperative blood loss were 183.6 ± 44.8 min and 54.8 ± 34.4 ml, respectively. A total of 15.3 ± 7.8 lymph nodes were harvested. The pain score 24 hours after operation was 1.3 ± 1.3. The time out of bed, the time to exhaust, and the time to eat were 15.6 ± 2.9 hours, 2.2 ± 0.8 days, and 2.1 ± 0.6 days, respectively. A total of 4 patients (14.8%) developed complications after the operation. Grade B anastomotic leakage gradually resolved after drainage and antibiotic therapy in 1 case. A patient with grade C anastomotic leakage received a second operation for ileostomy. One patient with postoperative pneumonia recovered after anti-infective treatment. Another patient with intraperitoneal hemorrhage improved after symptomatic treatment with blood transfusion and hemostasis. The postoperative hospitalization time and total hospitalization costs were 8.9 ± 4.4 days and 89236.1 ± 13527.9 yuan, respectively.
Conclusions
Manual suture with Da Vinci robotic surgery system is safe and feasible for reconstructing the digestive tract in rectal cancer surgery.
Electrically programmable magnetic coupling in an Ising network exploiting solid-state ionic gating
Authors: Yun Chao , Liang Zhongyu , Hrabec Ales , Liu Zhentao , Huang Mantao , Wang Leran , Xiao Yifei , Fang Yikun , Li Wei , Yang Wenyun , Hou Yanglong , Yang Jinbo , Gambardella Pietro , Heyderman Laura , Luo Zhaochu 
Published: June 2023

Abstract
Two-dimensional arrays of magnetically coupled nanomagnets provide a mesoscopic platform for exploring collective phenomena as well as realizing a broad range of spintronic devices. In particular, the magnetic coupling plays a critical role in determining the nature of the cooperative behaviour and providing new functionalities in nanomagnet-based devices. Here, we create coupled Ising-like nanomagnets in which the coupling between adjacent nanomagnetic regions can be reversibly converted between parallel and antiparallel through solid-state ionic gating. This is achieved with the voltage-control of magnetic anisotropies in a nanosized region where the symmetric exchange interaction favours parallel alignment and the antisymmetric exchange interaction, namely the Dzyaloshinskii-Moriya interaction, favours antiparallel alignment. Applying this concept to a two-dimensional lattice, we demonstrate a voltage-controlled phase transition in artificial spin ices. Furthermore, we achieve an addressable control of the individual couplings and realize an electrically programmable Ising network, which opens up new avenues to design nanomagnet-based logic devices and neuromorphic computers.
Osseous defects of radicular cysts after cystectomy repairing with autogenous tooth sticky bone graft in the maxillary aesthetic area
Authors: Wushou Alimujiang , Luo Yuan , Cheng Qing-tao , Yang Zhi-cheng 
Published: June 2023

Abstract
Background: Radicular cysts are the most frequent inflammatory odontogenic cysts of the jaw. Cystectomy of larger radicular cysts in the maxillary aesthetic area often results in collapsed lip deformities. BonMaker® ATB has been investigated and demonstrated excellent autogenous bone graft candidacy. The aim of this study is to share a single team’s experience in repairing osseous defects after cystectomy in the maxillary aesthetic area by using autogenous tooth sticky bone grafts prepared with extracted third molars.
Method: A total of 12 patients with radicular cysts and impacted third molars were enrolled in this retrospective clinical study. The whole procedure was performed under general anesthesia. First, the impacted third molars were extracted, and autogenous tooth sticky bone grafts were prepared by mixing autogenous fibrin glue. Subsequently, cystectomy and grafting were performed and covered with concentrated growth factors. The patients were followed up at four months.
Results: The 12 patients included seven males and five females with a median age of 26 years. Primary wound healing of the graft donor and receiving site was achieved in all patients without complications. Osseous defects of radicular cysts demonstrated satisfactory ossification without bone resorption during the postsurgical follow-up after four months.
Conclusion: Autogenous tooth sticky bone grafts show promising alveolar bone repair quality.
Isolation and laboratory evaluation of two strains of Aspergillus for controlling Haemaphysalis longicornis (Acari: Ixodidae)
Authors: Chen Yi , Peng Zhifeng , He Guifen , Xia Yanxun , Zhao Junlong , Wang Haiyan 
Published: June 2023

Abstract
Haemaphysalis longicornis (Acari: Ixodidae) is an important vector tick that can transmit a number of pathogens to humans and domestic animals worldwide. Entomopathogenic fungi have been substantiated to be effective in controlling ticks. However, a limited number of studies have assessed the use of ubiquitous Aspergillus spp. strains for the control of H. longicornis. In this study, we isolated Chinese native A. flavus and A. niger strains and evaluated their pathogenicity on different life stages of H. longicornis in the laboratory. Batches of unfed larvae, unfed nymphs and unfed female adults of H. longicornis (i.e., n = 20 for each stage) were immersed in 0.05% tween 80 suspensions of each A. fungus (1×105, 1×106, and 1×107 conidia/mL), whilst control groups for each stage were exposed only to sterile distilled water plus 0.05% Tween 80. All bioassays consisted of four groups of ticks (three experimental and one control group). Ticks were observed daily until 100% mortality was recorded in all treatment groups. Twelve days after treatment, A. flavus and A. niger strain resulted in 100% mortality of unfed tick larvae at all concentrations. Based on the calculated LC50 (median lethal concentration ) values, it was revealed that A. flavus was more pathogenic than A. niger. However, there was zero mortality and no mycelium growth in the nymph and adult female tick groups at all exposure times when using different conidial concentrations. Our results demonstrated that two native Chinese Aspergillus spp. strains showed high entomopathogenicity in the lab condition, representing a possible promising natural product to be used in alternative or in combination to other acaricidal compounds currently used for controlling the H. longicornis, although further field studies are needed to determine the best route and frequency of application for using these fungi as a bio-control agent against ticks.
A probabilistic load flow comparison in distribution systems by performing optimal capacitors/DERs sizing and placement, simultaneously
Authors: Khanbabaee Mohammad Mahbod , Abedi Bahman 
Published: June 2023

Abstract
Due to penetration of distributed energy resources (DER)s in electrical distribution systems, uncertainty investigation of distributed resources performance is significant owing to the inherent nature of solar irradiation and wind blow, on the other hand the power demand and charging stations of electric vehicles. All in all, uncertainty modeling of distribution network elements is an essential tool for performing probabilistic load flow (PLF) analysis beside understanding the probabilistic behavior of a power distribution network. Furthermore, the installation of DER resources and capacitors can result improvements of power factor, voltage profile enhancement and line losses reduction in power distribution networks. The sizing and location of DER resource and capacitor unit should be optimal to maximize the benefits, hence optimal locating and allocating the capacity of DERs have a complete impact on the system losses in the distribution network. When DERs and capacitors are installed in a distribution system, it could impact three-phase short-circuit currents. Genetic Algorithm (GA) is applied to find the optimal place and size of DERs and capacitors considering the minimum three-phase short-circuit current changes. The probability density functions (PDF) of total system losses and voltage deviation of the investigated network obtained from solving PLF by two methods of Monte Carlo simulation (MCS) and Hong’s two-point estimation method have been compared before and after optimal placement and sizing of distributed energy resources and capacitors. PLF and GA has been applied on IEEE 33-bus radial distribution system. The results obtained illustrate that the voltage deviation and the total system losses have been reduced with very minor changes in three-phase short-circuit current, finally the two-point estimation (TPM) method offer faster method, having acceptable results.
Study of new strain of Sanchytrium tribonematis expands our knowledge on Sanchytriomycota (Fungi)
Authors: Vishnyakov Andrey E. , Seliuk Alexei O. , Tcvetkova Victoria S. , Karpov Sergey 
Published: June 2023

Abstract
Recently, phylogenomic analyses of two parasitic fungi with amoeboid zoospores and long kinetosomes, the sanchytrids Amoeboradix gromovi and Sanchytrium tribonematis, showed that they formed a clade Sanchytriomycota sister to Blastocladiomycota. Sanchytrid species diversity is still very low and most of isolates from different places belong to S. tribonematis. Here, we present a new strain X-137 of fresh-water S. tribonematis having peculiar morphology and unusual stage in the life cycle. Its zoospores have kinetosome composed by 9 microtubular singlets along its whole length (1.2 µm) with pseudocilium containing axoneme of 4 microtubules, and enable to form extremely long posterior filopodium (up to 10 body lengths). Kinetosome develops from the mother centriole of centrosomal apparatus of sporangium, while daughter centriole becomes a non-flagellar kinetosome. Big zoospores with several pseudocilia and many (up to eleven) kinetosomes per cell have been found in S. tribonematis culture. They are probably a result of several zoospores or gametes fusion. These findings expand our still poor knowledge on the cell structure and biology of Sanchytriomycota.
ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer
Authors: Su Ping-ping , Mao Xiaodan , Ma Jincheng , Huang Lixiang , Yu Lirui , Tang Shuting , Zhuang Mingzhi , Lu Zhonglei , Osafo Kelvin Stefan , Ren Yuan , Wang Xinrui , Lin Xite , Huang Leyi , Huang Xiaoli , Braicu Elena Ioana , Sehouli Jalid , Sun Pengming 
Published: June 2023

Abstract
Background
Tumor cells can resist chemotherapy-induced pyroptosis through glycolytic reprogramming. Estrogen-related receptor alpha (ERRα) is a central regulator of cellular energy metabolism associated with poor cancer prognosis. Herein, we refine the oncogenic role of ERRα in the pyroptosis pathway and glycolytic metabolism.
Methods
The protein interaction between ERRα and HIF-1α was verified by Co-immunoprecipitation. The transcriptional binding sites of ERRα and NLRP3 were confirmed by dual-luciferase reporter assay. Flow cytometry, transmission electron microscopy, and extracellular acidification rate analysis were performed to investigate the effect of ERRα on the pyroptosis pathway and glycolytic metabolism. This experiments were further confirmed in EC-derived organoids and nude mice. In addition, the expression of ERRα-related pyroptosis genes was analyzed by the The Cancer Genome Atlas database.
Results
Triggered by a hypoxic microenvironment, highly-expressed-ERRα could bind to the promoter of NLRP3 and inhibit caspase-1/GSDMD signaling, which reduced inflammasome activation and increased pyroptosis resistance, thereby resulting in cancer cells resistant to cisplatin. Moreover, ERRα activated pyruvate kinase M2 (PKM2), a glycolytic rate-limiting enzyme, to bridge glycolytic metabolism and pyroptosis in endometrial cancer (EC). This phenomenon was further confirmed in EC-derived organoids and nude mice. The Cancer Genome Atlas database analysis showed that ERRα participated in glycolysis and programmed cell death, which resulted in the progression of EC.
Conclusions
ERRα inhibits pyroptosis in an NLRP3-dependent manner and induces glycolytic metabolism, resulting in cisplatin resistance in EC cells.
The mediating role of frailty and depression between social support and self-management pathway in elderly COPD patients: a cross-sectional study
Authors: Zhao Jie , Zhang Xiaona , Li Xindan , Zhang Rui , Chang Yan , Li Yongju , Lu Hongyan 
Published: June 2023

Abstract
Objectives: Chronic obstructive pulmonary disease (COPD) represents a serious threat to global public health safety, and no effective way to cure COPD has been identified. Its treatment is mainly focused on stabilization of the stage and reduction of symptoms. Self-management (SM) is the primary factor in controlling the progress of the disease. Social support has been proven to have a promoting effect on self-management; however, one independent factor cannot fully account for the complex mechanisms of self-management. The incidence of frailty and depression is relatively high among patients with COPD, which influences their level of SM. Unfortunately, there is still a lack of research on the underlying mechanisms among the four variables mentioned above. The aim of this study is to understand the current status of social support and self-management in elderly patients with COPD, and to explore the double mediating role of depression and frailty between social support and self-management.
Study design: This is a cross-sectional study.
Methods: This study used a convenience sampling method, and selected 627 elderly COPD patients who was hospitalized in 5 public hospitals in the Ningxia region of northwest China from November 2020 to July 2021 as the survey subjects. The survey content included general information, the COPD Self-management Scale (COPD-SMS), Frail Scale (FS), 15-item Geriatric Depression Scale (15-GDS), and Social Support Rating Scale (SSRS). The correlation between variables used Pearson’s product-moment correlation analysis. SPSS25.0 PROCESS plugin Model 6 was used to test the mediating effect of frailty and depression between social support and self-management.
Results: Among the sample, the total participants contained 248 females and 379 males. The mean age was 72.87 years, and the standard deviation was 7.03. The mean COPD-SMS was 156.99, with a standard deviation of 25.15. Analysis of the mediating effect revealed that social support can directly predict SM, and can also predict through the mediation of depression and frailty-depression, but the mediation of frailty alone was not significant. The direct and indirect effect accounted for 84.06% and 15.94% of the total effect respectively.
Conclusion: The SM of elderly COPD patients in the Ningxia of northwest China was at a moderate-to-low level, and the frailty and depression played a partial mediating role in social support and self-management pathways. The research provided that the medical profession should pay attention to the patients' frailty and depression status and provide targeted intervention measures during the intervention.
The Evolution of Age-Specific Smoking Cessation Rates in the United States From 2009 to 2018
Authors: Le Thuy T.T. , Warner Kenneth E. , Mendez David 
Published: June 2023

Abstract
Objective
Tracking the US smoking cessation rate over time is of great interest to tobacco control researchers and policymakers since smoking cessation behaviors have a major effect on the public’s health. A couple of recent studies have employed dynamic models to estimate the US cessation rate through observed smoking prevalence. However, none of those studies has provided recent annual estimates of the cessation rate by age group.
Methods
We employed a Kalman filter approach to investigate the annual evolution of age-group-specific cessation rates, unknown parameters of a mathematical model of smoking prevalence, during the 2009–2018 period using data from the National Health Interview Survey. We focused on cessation rates in the 24–44, 45–64 and 65 + age groups.
Results
The findings show that cessation rates follow a consistent u-shaped curve over time with respect to age (i.e., higher among the 25–44 and 65 + age groups, and lower among 45-64-year-olds). Over the course of the study, the cessation rates in the 25–44 and 65 + age groups remained nearly unchanged around 4.5% and 5.6%, respectively. However, the rate in the 45–64 age group exhibited a substantial increase of 70%, from 2.5% in 2009 to 4.2% in 2017. The estimated cessation rates in all three age groups tended to converge to the weighted average cessation rate over time.
Conclusions
The Kalman filter approach offers a real-time estimation of cessation rates that would be helpful for monitoring smoking cessation behavior, of interest in general but also for tobacco control policymakers.