bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Banks Worry about Attentive Depositors? Evidence from Multiple-Brand Banks
Authors: Chavaz Matthieu , Slutzky Pablo 
Published: May 2023

Abstract
Panic-based (non-fundamental) spikes in depositors’ attention can be a source of bank fragility in theory, but separating such spikes from underlying fundamentals is challenging empirically. Using online search data, we show that during the Global Financial Crisis, UK banks facing surges in attention respond by increasing retail deposit rates, but only for instant withdrawal deposits. Exploiting variation across brands owned by the same bank (and thus sharing the same fundamentals), we find that banks respond even when surges are not justified by fundamentals. In addition, comparing onshore and offshore deposits by the same brand, we show that bank response is substantially stronger when the lack of deposit insurance and a larger presence of wholesale depositors magnifies potential losses to depositors.
15Theatre and Performance
Authors: Simpson Hannah 
Published: May 2023

Abstract
It’s a cliché, of course, to open an annual review by pointing out how the texts under discussion reflect our contemporary moment. And none of the books reviewed here are modish responses to passing scholarly fads. All speak first and foremost to concerns located at the very heart of the theatre medium itself: the imaginative construction of alternative shared worlds, and the exploration of our hopes and fears around modes of interpersonal touch and intimacy. So, forgive me just one brief reflection on how it is surely no coincidence that the books that intervene most excitingly and meaningfully in the scholarly field this year are also those that speak to some of the most pressing anxieties and desires in the broader world as well, in the wake of pandemic contagion, the #MeToo movement, a cost-of-living crisis, and continued dystopic crises in both the academic industry and in national and global politics.
The first section of this chapter, ‘Utopia’, reviews three monographs that discuss the intersections between theatre, concepts of utopia and utopian thinking: Siân Adiseshiah’s Utopian Drama: In Search of a Genre, Selina’s Busby’s Applied Theatre: A Pedagogy of Utopia and Ryan Claycomb’s In the Lurch: Verbatim Theater and the Crisis of Democratic Deliberation. The second section, ‘Touch and Intimacy’, reviews two books that cast an eye on questions of touch and intimacy onstage, from a contemporary practice-based and historical scholarly perspective respectively: Supporting Staged Intimacy: A Practical Guide for Theatre Creatives, Managers, and Crew, co-authored by Alexis Black and Tina M. Newhauser, and Alex MacConochie’s Staging Touch in Shakespeare’s England.
8Film Theory
Authors: Lash Dominic 
Published: May 2023

Abstract
This chapter discusses three notable books concerning film theory that were published in 2022 which are particularly significant in what they reveal about the current understanding of form within the discipline. The chapter is divided into four sections: 1. Kyle Stevens (ed.), The Oxford Handbook of Film Theory; 2. Eugenie Brinkema, Life-Destroying Diagrams; 3. Jordan Schonig, The Shape of Motion: Cinema and the Aesthetics of Movement. 4. Conclusion.
The Temporal Relationship Between the Coronavirus Disease 2019 (COVID-19) Pandemic and Preterm Birth
Authors: Grobman William A. , Sandoval Grecio J. , Metz Torri D. , Manuck Tracy A. , Clifton Rebecca G. , Hughes Brenna L. , Saade George R. , Longo Monica , Sowles Amber , Clark Kelly , Simhan Hyagriv N. , Rouse Dwight J. , Mendez-Figueroa Hector , Gyamfi-Bannerman Cynthia , Bailit Jennifer L. , Costantine Maged M. , Sehdev Harish M. , Tita Alan T. N. , Macones George A. 
Published: May 2023

OBJECTIVE:
To evaluate whether preterm birth rates changed in relation to the onset of the coronavirus disease 2019 (COVID-19) pandemic and whether any change depended on socioeconomic status.

METHODS:
This is an observational cohort study of pregnant individuals with a singleton gestation who delivered in the years 2019 and 2020 at 1 of 16 U.S. hospitals of the Maternal-Fetal Medicine Units Network. The frequency of preterm birth for those who delivered before the onset of the COVID-19 pandemic (ie, in 2019) was compared with that of those who delivered after its onset (ie, in 2020). Interaction analyses were performed for people of different individual- and community-level socioeconomic characteristics (ie, race and ethnicity, insurance status, Social Vulnerability Index (SVI) of a person's residence).

RESULTS:
During 2019 and 2020, 18,526 individuals met inclusion criteria. The chance of preterm birth before the COVID-19 pandemic was similar to that after the onset of the pandemic (11.7% vs 12.5%, adjusted relative risk 0.94, 95% CI 0.86–1.03). In interaction analyses, race and ethnicity, insurance status, and the SVI did not modify the association between the epoch and the chance of preterm birth before 37 weeks of gestation (all interaction P>.05).

CONCLUSION:
There was no statistically significant difference in preterm birth rates in relation to the COVID-19 pandemic onset. This lack of association was largely independent of socioeconomic indicators such as race and ethnicity, insurance status, or SVI of the residential community in which an individual lived.
Effect of a Multimedia Educational Tool on Contraception Use 1 Year Postpartum
Authors: Qureshey Emma J. , Ibarra Claudia J. , Wagner Stephen M. , Chen Han-Yang , Ashimi Sunbola , Ross Patti Jayne , Blackwell Sean C. , Sibai Baha M. , Chauhan Suneet P. 
Published: May 2023

Almost half of all pregnancies are unintended, and individuals with high-risk medical conditions are disproportionately affected. We previously published results from our randomized controlled trial, which showed an increase in the use of long-acting reversible contraceptives (LARC) at 12 weeks postpartum in a high-risk population after the use of a multimedia educational tool (MET group) compared with routine care (RC group). Here we report a planned analysis of the 1-year follow-up of that trial using electronic surveys of the trial participants. At 1 year postpartum, LARC use was similar between groups (30.3% vs 21.7%, relative risk [RR] 1.40, 95% CI 0.95–2.05), but overall contraceptive use was significantly higher in the MET group compared with the RC group (81.6% vs 70.7%; P=0.03, RR 1.15, 95% CI 1.02–1.31, number needed to treat 9). The use of a multimedia educational tool increased the overall use of contraception at 1 year postpartum in individuals with an antecedent high-risk pregnancy.

FUNDING SOURCE:
Supported in part by a research grant from Investigator-Initiated Studies program of Organon. The opinions expressed in this paper are those of the authors and do not necessarily represent Organon.

CLINICAL TRIAL REGISTRAION:

ClinicalTrials.gov, NCT04291040.
The first hour of trauma reception is critical for patients with major thoracic trauma
Authors: Helsloot Dries , Fitzgerald Mark C. , Lefering Rolf , Verelst Sandra , Missant Carlo 
Published: May 2023

BACKGROUND
Up to 25% of trauma deaths are related to thoracic injuries.

OBJECTIVE
The primary goal was to analyse the incidence and time distribution of death in adult patients with major thoracic injuries. The secondary goal was to determine if potentially preventable deaths occurred within this time distribution and, if so, identify an associated therapeutic window.

DESIGN
Retrospective observational analysis.

SETTING
TraumaRegister DGU.

PATIENTS
Major thoracic injury was defined as an Abbreviated Injury Scale (AIS) 3 or greater. Patients with severe head injury (AIS ≥ 4) or injuries to other body regions with AIS being greater than the thoracic injury (AIS other >AIS thorax) were excluded to ensure that the most severe injury described was primarily thoracic related.

MAIN OUTCOME MEASURES
Incidence and time distribution of mortality were considered the primary outcome measures. Patient and clinical characteristics and resuscitative interventions were analysed in relation to the time distribution of death.

RESULTS
Among adult major trauma cases with direct admission from the accident scene, 45% had thoracic injuries and overall mortality was 9.3%. In those with major thoracic trauma (n = 24 332) mortality was 5.9% (n = 1437). About 25% of these deaths occurred within the first hour after admission and 48% within the first day. No peak in late mortality was seen. The highest incidences of hypoxia and shock were seen in non-survivors with immediate death within 1 h and early death (1 to 6 h). These groups received the largest number of resuscitative interventions. Haemorrhage was the leading cause of death in these groups, whereas organ failure was the leading cause of death amongst those who survived the first 6 h after admission.

CONCLUSION
About half of adult major trauma cases had thoracic injuries. In non-survivors with primarily major thoracic trauma, most deaths occurred immediately (<1h) or within the first 6 h after injury. Further research should analyse if improvements in trauma resuscitation performed within this time frame will reduce preventable deaths.

TRIAL REGISTRATION
The present study is reported within the publication guidelines of the TraumaRegister DGU® and registered as TR-DGU project ID 2020-022.
Student Nurse Screening, Brief Intervention and Referral to Treatment Training Program
Authors: Zucker Donna M. , Rataj Suzanne , Linowski Sally , DiFulvio Gloria T. , Fedorchak Diane , Dion Kimberly , Chandler Genevieve E. 
Published: May 2023

Abstract

Background
Screening, brief intervention and referral to treatment (SBIRT) is an evidence-based set of skills and strategies used by health care providers. Data have suggested SBIRT should be used in detecting persons at risk for substance use and be included in every primary care encounter, as many needing substance abuse treatment do not receive it.

Methods
This descriptive study evaluated data for 361 undergraduate student nurses who participated in SBIRT training. Pretraining and 3-month posttraining surveys were used to evaluate changes in trainees' knowledge, attitudes, and skills toward people with substance use disorder. A satisfaction survey immediately after the training measured satisfaction with and usefulness of the training.

Results
Eighty-nine percent of students self-reported that the training increased their knowledge and skills related to screening and brief intervention. Ninety-three percent reported that they intended to use these skills in the future. Pre–post measures indicated statistically significant increases in knowledge, confidence, and perceived competence on all measures.

Conclusions
Both formative and summative evaluation assisted in improving trainings each semester. These data confirm the need to integrate SBIRT content across the undergraduate nursing curriculum and include faculty and preceptors to improve rates of screening in clinical practice.
Increasing Awareness on Substance Use Disorder
Authors: Scott Jennifer , Schachman Kathleen , Hupert Cynthia 
Published: May 2023

Abstract

Background
There is a lack of substance use disorder (SUD) providers in the micropolitan Midwestern state. Individuals who live in rural areas with SUD may have a gap in treatment for their addiction.

Objective
The objective of this quality improvement project was to increase the engagement, participation, and awareness of rural primary care providers in treatment of individuals with SUD.

Methods
This is a quality improvement project that utilized a skip-logic standardized survey to evaluate participants who attended Project ECHO (Extension for Community Healthcare Outcomes) Addiction educational sessions.

Results
Findings included 176 participants over 14 sessions, while reaching primary care providers in 62 clinics over a 7-month period. However, it was found that only half of those participants completed the survey. A variety of topics surrounding SUD were offered. In addition, each session included a case study with feedback provided by the team. Seventy participants (79%) rated “strongly agree” and “agree” to “I will make changes to my practice.” Participants provided feedback as to how they would change their practice after an educational session; responses included adapting how naltrexone is prescribed based on the recommendations made during the presentation, update treatment guidelines, screen for adverse childhood experiences, utilize motivational interviewing, feeling more confident in providing medication-assisted treatment for patients, and finally, better able to manage pain in those with SUD.

Conclusion
Project ECHO Addiction is an evidence-based translational quality improvement project that reaches rural primary care providers to help increase awareness, engagement, and networking in treatment of patients with SUD, which in turn improves patient outcomes as they receive treatment in a timely fashion.
Opioid Use Disorder
Authors: Griffith Patricia S. , Brown Lana M. , Lensing Shelly Y. , Nahata Ravi , Padala Prasad R. , Snow Lisa , Milholland Katherine , Mullins Melinda 
Published: May 2023

Abstract

Background
Substance use disorders are a leading cause of morbidity and mortality in the United States, with opioid use disorder representing a growing public health concern and economic burden. Veterans within the Veterans Health Administration are impacted by opioid use disorder.

Significance
A common medication-assisted treatment is sublingual Suboxone (buprenorphine/naloxone) used in combination with behavior modification therapy. Missed Suboxone doses may lead to withdrawal and potential drug diversion. Sublocade (buprenorphine extended-release) is an alternative once-monthly subcutaneous injection administered by a healthcare provider. The purpose of this quality improvement project was to examine the effects of Sublocade on cravings in veterans with opioid use disorder.

Methods
Veterans were considered for Sublocade monthly injections if they were enrolled in the Suboxone program, not taking Suboxone as prescribed, and disenrolled from the Suboxone program more than 2 times. Cravings were measured before and after Sublocade program enrollment.

Results
Fifteen veterans were enrolled in the Sublocade program over a 12-month timeframe. Most were male (93%) with a median (range) age of 42 (33–62) years. The following were the primary opioids used before enrollment in the substance use disorder program: hydrocodone (47%), oxycodone (20%), and heroin (20%). Sublocade significantly reduced cravings (p = .001). In this small group, cravings were fully eliminated.

Discussion
Recent studies have shown Sublocade effectively blocks the effects of other opioids and minimizes the risk of medication diversion that occurs with Suboxone. For these reasons, Sublocade is an alternative medication-assisted treatment for veterans with opioid use disorder.
Associations Between Clinic-Based HIV Testing Guidelines and Population-Level HIV Testing Rates in the United States
Authors: Siddiqi Khairul A. , Gwynn Melanie , Olatosi Bankole , Ostermann Jan 
Published: May 2023

Abstract
Between 2005 and 2006, the United States Preventive Services Task Force and the Centers for Disease Control and Prevention revised their risk-based HIV testing guidelines to include universal HIV testing in routine health care. We examined trends in HIV testing and associations with changing policy recommendations using the 2000–2017 National Health Interview Surveys. Multivariable logistic regression and difference-in-difference approach were used to assess rates and correlates of HIV testing before and after the policy changes. Changes in recommendations had minimal effects on overall HIV testing rates but had significant effects on selected subpopulations. The odds of HIV testing increased disproportionately among African Americans, Hispanics, individuals with some college education, low perceived HIV risks, and those who were never married but decreased among those with no regular source of care. A strategy combining risk-based and routine opt-out testing holds promise to rapidly link recently infected individuals to care while reaching individuals who have never been tested.
Development and Validation of HAS (Hajibandeh Index, ASA Status, Sarcopenia) - A Novel Model for Predicting Mortality After Emergency Laparotomy
Authors: Hajibandeh Shahab , Hajibandeh Shahin , Hughes Ioan , Mitra Kalyan , Puthiyakunnel Saji Alwin , Clayton Amy , Alessandri Giorgio , Duncan Trish , Cornish Julie , Morris Chris , O’Reilly David , Kumar Nagappan 
Published: May 2023

Objectives:
To develop and validate a predictive model to predict the risk of postoperative mortality after emergency laparotomy taking into account the following variables: age, age ≥ 80, ASA status, clinical frailty score, sarcopenia, Hajibandeh Index (HI), bowel resection, and intraperitoneal contamination.

Summary Background Data:
The discriminative powers of the currently available predictive tools range between adequate and strong; none has demonstrated excellent discrimination yet.

Methods:
The TRIPOD and STROCSS statement standards were followed to protocol and conduct a retrospective cohort study of adult patients who underwent emergency laparotomy due to non-traumatic acute abdominal pathology between 2017 and 2022. Multivariable binary logistic regression analysis was used to develop and validate the model via two protocols (Protocol A and B). The model performance was evaluated in terms of discrimination (ROC curve analysis), calibration (calibration diagram and Hosmer-Lemeshow test), and classification (classification table).

Results:
One thousand forty-three patients were included (statistical power = 94%). Multivariable analysis kept HI (Protocol-A: P=0.0004; Protocol-B: P=0.0017), ASA status (Protocol-A: P=0.0068; Protocol-B: P=0.0007), and sarcopenia (Protocol-A: P<0.0001; Protocol-B: P<0.0001) as final predictors of 30-day postoperative mortality in both protocols; hence the model was called HAS (HI, ASA status, sarcopenia). The HAS demonstrated excellent discrimination (AUC: 0.96, P<0.0001), excellent calibration (P<0.0001), and excellent classification (95%) via both protocols.

Conclusions:
The HAS is the first model demonstrating excellent discrimination, calibration, and classification in predicting the risk of 30-day mortality following emergency laparotomy. The HAS model seems promising and is worth attention for external validation using the calculator provided. HAS mortality risk calculator https://app.airrange.io/#/element/xr3b_E6yLor9R2c8KXViSAeOSK.
UDCA May Promote COVID-19 Recovery: A Cohort Study with AI-Aided Analysis
Authors: Yu Yang , Yu Guo , Han Lu-Yao , Li Jian , Zhang Zhi-Long , Liu Tian-Shuo , Li Ming-Feng , Zhan De-Chuan , Tang Shao-Qiu , Zhou Zhi-Hua , Wang Guang-Ji 
Published: May 2023

AbstractTo investigate the impact of ursodeoxycholic acid (UDCA) treatment on the clinical outcome of mild and moderate COVID-19 cases, a retrospective analysis was conducted to evaluate the efficacy of UDCA on patients diagnosed with COVID-19 during the peak of the Omicron outbreak in China. This study presents promising results, demonstrating that UDCA significantly reduced the time to Body Temperature Recovery after admission and a higher daily dose seems to be associated with a better outcome without observed safety concerns. We also introduced VirtualBody, a physiologically plausible artificial neural network model, to generate an accurate depiction of the drug concentration-time curve individually, which represented the absorption, distribution, metabolism, and excretion of UDCA in each patient. It exhibits exceptional performance in modeling the complex PK-PD profile of UDCA, characterized by its endogenous and enterohepatic cycling properties, and further validates the effectiveness of UDCA as a treatment option from the drug exposure-response perspective. Our work highlights the potential of UDCA as a novel treatment option for periodic outbreaks of COVID-19 and introduces a new paradigm for PK-PD analysis in retrospective studies to provide evidence for optimal dosing strategies.
Six3 and Six6 jointly regulate the identities and developmental trajectories of multipotent retinal progenitor cells in the mouse retina
Authors: Ferrena Alexander , Zhang Xusheng , Shrestha Rupendra , Zheng Deyou , Liu Wei 
Published: May 2023

AbstractFormation, maintenance, and differentiation of tissue-specific progenitor cells are fundamental tasks during organogenesis. Retinal development is an excellent model for dissecting these processes; mechanisms of retinal differentiation can be harnessed for retinal regeneration toward curing blindness. Using single-cell RNA sequencing of embryonic mouse eye cups in which transcription factor Six3 was conditionally inactivated in peripheral retinas on top of germline deletion of its close paralog Six6 (“DKO”), we identified cell clusters and then inferred developmental trajectories in the integrated dataset. In control retinas, naïve retinal progenitor cells had two major trajectories leading to ciliary margin cells and retinal neurons, respectively. The ciliary margin trajectory was directly from naïve retinal progenitor cells at G1 phase, and the retinal neuron trajectory was through a neurogenic state marked byAtoh7expression. UponSix3andSix6dual deficiency, both naïve and neurogenic retinal progenitor cells were defective. Ciliary margin differentiation was enhanced, and multi-lineage retinal differentiation was disrupted. An ectopic neuronal trajectory lacking the Atoh7+ state led to ectopic neurons. Differential expression analysis not only confirmed previous phenotype studies but also identified novel candidate genes regulated bySix3/Six6. Six3 and Six6 were jointly required for balancing the opposing gradients of the Fgf and Wnt signaling in the central-peripheral patterning of the eye cups. Taken together, we identify transcriptomes and developmental trajectories jointly regulated by Six3 and Six6, providing deeper insight into molecular mechanisms underlying early retinal differentiation.
Human Fis1 directly interacts with Drp1 in an evolutionarily conserved manner to promote mitochondrial fission
Authors: Nolden Kelsey A. , Harwig Megan C. , Hill R. Blake 
Published: May 2023

AbstractMitochondrial Fission Protein 1 (Fis1) and Dynamin Related Protein 1 (Drp1) are the only two proteins evolutionarily conserved for mitochondrial fission, and directly interact inS. cerevisiaeto facilitate membrane scission. However, it remains unclear if a direct interaction is conserved in higher eukaryotes as other Drp1 recruiters, not present in yeast, are known. Using NMR, differential scanning fluorimetry, and microscale thermophoresis, we determined that human Fis1 directly interacts with human Drp1 (KD= 12-68 µM), and appears to prevent Drp1 assembly, but not GTP hydrolysis. Similar to yeast, the Fis1-Drp1 interaction appears governed by two structural features of Fis1: its N-terminal arm and a conserved surface. Alanine scanning mutagenesis of the arm identified both loss- and gain-of-function alleles with mitochondrial morphologies ranging from highly elongated (N6A) to highly fragmented (E7A) demonstrating a profound ability of Fis1 to govern morphology in human cells. An integrated analysis identified a conserved Fis1 residue, Y76, that upon substitution to alanine, but not phenylalanine, also caused highly fragmented mitochondria. The similar phenotypic effects of the E7A and Y76A substitutions, along with NMR data, support that intramolecular interactions occur between the arm and a conserved surface on Fis1 to promote Drp1-mediated fission as inS. cerevisiae. These findings indicate that some aspects of Drp1-mediated fission in humans derive from direct Fis1-Drp1 interactions that are conserved across eukaryotes.