bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of verdinexor as a canine P‐glycoprotein substrate
Authors: Mealey Katrina L. , Burke Neal S. 
Published: March 2023

AbstractThe P‐glycoprotein (P‐gp) substrate status of antineoplastic drugs intended for veterinary patients is an important characteristic to define for two reasons. First, neoplastic cells expressing P‐gp can actively efflux drugs that are P‐gp substrates curtailing their efficacy. Second, antineoplastic drugs tend to have a narrow therapeutic index. Antineoplastic drugs that are P‐gp substrates can cause severe adverse reactions in animals with P‐gp dysfunction such as dogs with ABCB1‐1Δ and cats with ABCB11930_1931del TC. Animals with P‐gp dysfunction experience greater overall exposure to P‐gp substrate drugs due to mechanisms such as increased intestinal absorption, decreased biliary clearance and greater central nervous system penetration compared with animals with normal P‐gp function. Accordingly, knowing the P‐gp substrate status of antineoplastic drugs is an important safety consideration prior to use in canine or feline cancer patients. This study used a cell line overexpressing canine P‐gp to assess the P‐gp substrate status of verdinexor. Based on both a cytotoxicity assay and a competitive flow cytometry assay verdinexor is not a substrate for canine P‐gp.
Destination imaging, compatibilities with intellectual property rights‐based tourism industry
Authors: Dar Mohamad Ayub , Ojha Megha 
Published: March 2023

AbstractIntellectual property pervades all aspects of life. Sustaining intellectual creations is often debatable. The abounding atmosphere of progress and development encompasses other industries as well. Tourism is a major economic driver that promotes social and cultural exchange while directly and indirectly employing millions of people. Destination branding is promoted by tourism. After the 2010 Eyjafjallajökul eruption, Iceland's reputation as a safe tourist destination plummeted. Iceland's government promoted the “Inspired by Iceland” brand to attract tourists. The brand is a symbol, mark, logo, name, word, or sentence used to distinguish one product from another. The paper examines the relationship between intellectual property rights (IPR) and tourism. Geographical indications (GI) have a huge impact on regional tourism. The GI manufacturing process and cultivation tend to attract tourists. Travelers often want to sample regional foods, flavors, aromas, and beverages and buy them directly from consumers, resulting in a tourist influx. The capitalist notion of destination branding is abandoned as the IPR‐based tourism sector is revived. It also promotes the best way to develop the tourism industry while protecting IPRs. The link is also heavily emphasized to promote tourism. Regional development and eco‐tourism policies should be promoted. The tourism industry benefits greatly from protecting indigenous communities and their traditional knowledge.
Normativity and the Critical Functions of Genealogy: The Case of Modern Science1
Authors: Harrison Peter 
Published: March 2023

AbstractThe first part of this article offers some general remarks about genealogical approaches to history, focusing on historical narratives that stress the role played by theological considerations in the formation of aspects of secular modernity. A central question is whether such genealogies can serve to critique the present without drawing upon contestable moral or religious commitments. I suggest that genealogies fulfil this function when they identify inconsistencies in putatively neutral or secular stances by revealing how their coherence ultimately relies upon unacknowledged theological foundations. Key figures in this initial discussion include Friedrich Nietzsche, Karl Löwith, Hans Blumenberg, Carl Schmitt, Walter Benjamin, Alasdair MacIntyre, John Milbank, and Brad Gregory. The second part of this article sets out a theological genealogy of modern science, offering it as a test case for some of the analytical considerations outlined in the first part. These latter sections are a summary of my own previous arguments about the theological foundations of modern science, considered under the description of theological genealogy. Here I discuss the religious legitimation of modern science, the origins of the idea of laws of nature, and the role played by theological anthropology in the development of experimental methods of inquiry.
Watershed health and ecological security modeling using anthropogenic, hydrologic, and climatic factors
Authors: Sadeghi Seyed Hamidreza , Zabihi Silabi Mostafa , Sarvi Sadrabad Hossein , Riahi Mohammadreza , Modarresi Tabatabaei Sedigheh 
Published: March 2023

AbstractAssessing the health and security of natural ecosystems is unavoidable to regulate and manage deterioration and prioritize management and conservation activities. As a result, the current study was conducted to assess the health and ecological security of the Galazchai Watershed in Oshnavieh Township, West Azerbaijan Province, Iran, utilizing criteria linked to various hydrologic, anthropogenic, and climatic aspects. In the conceptual pressure–state–response (PSR) method, 26 criteria with acceptable variance inflation factor and Durbin–Watson statistics were chosen. The Galazchai Watershed's ecology's health and security status and spatial differences were also chosen and analyzed at 17 subwatersheds. The contributions of the pressure (P), status (S), and reaction (R) indices to the watershed health index were 38.3, 30.1, and 31.6%, respectively, according to the findings. The health index for the watershed ranged from 0.388 to 0.688. Almost 64% of the watershed's area was in relatively healthy conditions. Additionally, the maximum and the minimum values of the ecological security index were 0.608 and 0.236, allocating 58% of the area to moderate ecological security. The northern part of the watershed had healthier and moderately desirable ecological security than the southern part, with unhealthy and relatively undesirable conditions. In this sense, the main problems of the study area were primarily related to anthropogenic factors followed by hydrologic ones. The procedure used in the current study based on health and ecological security status can be applied as a practical guideline by local managers for efficient and adaptive watershed management.
Teleconsultation in pediatric anesthesia: First assessment of feasibility, quality, and satisfaction in France
Authors: Kern Delphine , Bourdaud Nathalie , Jaber Haithem , Ezzitouni Mounir , Alacoque Xavier , Larcher Claire , Sabourdin Nada , Minville Vincent 
Published: March 2023

AbstractIntroductionThe COVID‐19 pandemic has prompted the development of anesthesia teleconsultation in many countries. In pediatric anesthesia, data about anesthesia teleconsultation are scarce. The main objective of this prospective descriptive study was to provide an evaluation of the feasibility of pediatric anesthesia teleconsultation. Perception of the safety and quality, parental and medical satisfaction were also assessed.MethodsFrom September to December 2020, patients undergoing a pediatric anesthesia teleconsultation in Toulouse University Hospital, using the TeleO™ dedicated teleconsultation platform were prospectively included. Feasibility was defined as the rate of anesthesia teleconsultations successfully performed using the TeleO™ platform alone. Questionnaires regarding the quality, safety, and satisfaction were filled in by physicians and families.ResultsA total of 114 children (3 months–17 years) were included in the study. Feasibility was 82%, failure was mainly caused by technical issues. Physicians estimated that the safety and quality of anesthetic preparation were optimal in 100% of cases. Anesthetists were satisfied (VAS ≥70/100) with the medical, technical, and relational (child/parents) aspects of anesthesia teleconsultation in 91%, 64%, and 84%/90% of cases respectively. Almost all parents (97%) stated that they would agree to anesthesia teleconsultation for a future procedure.ConclusionIn this first assessment, pediatric anesthesia teleconsultation appears to be feasible, with high rates of medical and parental satisfaction. Physicians' perception of the safety and quality of this process were positive. Improving the technical process might be a key determinant to promote further development of pediatric anesthesia teleconsultation.
The influence of cross unconditional stimulus reinstatement on electrodermal responding and conditional stimulus valence in differential fear conditioning
Authors: Luck Camilla C. , Patterson Rachel R. , Lipp Ottmar V. 
Published: March 2023

AbstractWe examined whether the inhibitory Conditional Stimulus (CS)—no Unconditional Stimulus (US) association formed during extinction can be triggered by a novel US during the reinstatement of conditional electrodermal responding and self‐reported CS valence in human differential fear conditioning. Participants were trained with either a shock or an aversive scream US before undergoing extinction. Participants then received either the same (i.e., shock_shock or scream_scream) or a different US during reinstatement (i.e., shock_scream, scream_shock). Differential conditioning across all indices was stronger when a shock US was used during acquisition. After reinstatement, electrodermal responding to both the CS+ and the CS− increased regardless of the type of US used during reinstatement (non‐differential reinstatement). Differential CS valence evaluations were larger after reinstatement in the groups that received the same US during acquisition and reinstatement (differential reinstatement), but differential evaluations did not increase in the groups receiving a different US at reinstatement. This dissociation suggests that the reinstatement of negative stimulus valence and the reinstatement of expectancy learning may differ.
Potential role for human menopausal gonadotropin in ovine superovulatory regimens during the breeding season
Authors: Zhang Jing , Lu Xiaoyu , Liu Yiyong , Wu Xinglong , Yu Yuansong , Li Xiangyun 
Published: March 2023

AbstractHuman menopausal gonadotrophin (hMG) has been reported to produce a comparable superovulatory response to that of follicle stimulating hormone (FSH). Furthermore, hMG has a long half‐life as compared with FSH. The present study was designed to compare hMG administered once daily and FSH administered twice daily over a 4 ‐ day period on superovulatory response of Suffolk ewes. During the mid‐luteal phase, twenty‐four Suffolk donor ewes received intravaginal sponges at day 0 for 12 days. The superovulatory regimens in the Control group (n = 12) and the Treatment group (n = 12) consisted of eight injections of FSH given at twice daily and four injections of hMG given at once daily, respectively. At day 13, the donor ewes were subjected to laparoscopic insemination. Embryos were recovered, classified, and transferred to recipient ewes at day 19. Pregnancy status was determined by ultrasound examination 40 days after transfer. Lambing rate was calculated after all the ewes had delivered. No significant differences were observed between the two groups in terms of the structures recovered, transferable embryos, degenerated embryos, unfertilized oocytes, pregnancy rate and lambing rate. The results showed that once daily injection of hMG can produce a comparable superovulatory response and embryo transfer outcomes to those obtained by twice daily injection of FSH over a 4 ‐ day period. It is feasible that hMG is used to replace FSH and reduce the number of injection treatments in ovine superovulatory regimens.
The Effect of Remote Myofascial Release on Chronic Nonspecific Low Back Pain With Hamstrings Tightness
Authors: Tamartash Hassan , Bahrpeyma Farid , Dizaji Manijhe Mokhtari 
Published: March 2023

Context: Anatomy trains theory states that performing techniques in any part of the superficial myofascial backline can remotely treat other parts of this pathway. Due to the connections of different parts of the superficial backline, it is possible to influence the hamstring by performing the technique in the lumbar area. As chronic nonspecific low back pain (LBP) may lead to or be caused by hamstring tightness, remote myofascial release (MFR) techniques using the superficial backline can help improve hamstring tightness. Objective: This study aimed to evaluate the effect of remote MFR on hamstring tightness for those with chronic nonspecific LBP. Design: Single-blind, parallel design. Setting: The present study was performed at the clinical setting of Tarbiat Modares University in Iran. Methods: This study included 40 participants (20 males and 20 females) who were 40.5 (5.3) years old with chronic nonspecific LBP and hamstring tightness. Interventions: Participants were randomly divided into the lumbar MFR (remote area) and hamstring MFR groups. Participants underwent 4 sessions of MFR for 2 weeks. Main Outcome Measures: A passive knee-extension (PKE) test was used for muscle tightness evaluation 3 times. Results: Repeated-measure analysis of variance test showed that after the lumbar and hamstring MFR, the PKE was significantly reduced in both legs: lumbar MFR (right knee: from 61.04° [2.17°] to 51.01° [4.11°], P ≤ .003 and left knee: from 63.02° [3.12°] to 52.09° [2.48°], P ≤ .004) and hamstring MFR (right knee: from 62.01° [4.32°] to 50.50° [7.18°], P ≤ .001 and left knee: from 63.11° [2.56°] to 51.32° [5.31°], P ≤ .002). Least Significant Difference (LSD) post hoc test results showed that the 2 groups were not significantly different after the MFR (P ≥ .05). Also, the intraclass correlation coefficient index showed that the PKE test has excellent reliability (intraclass correlation coefficient, .910 for the right limb and .915 for the left limb). The minimal detectable change at the 95% confidence interval indicated that a change greater than or equal to 6° is required to exceed the threshold of the error PKE test, respectively. Conclusion: The present study showed that the remote MFR technique to the lumbar region demonstrated the same significant results in decreasing hamstring tightness as was noted in hamstring MFR to both limbs in patients with chronic nonspecific LBP.
Incidence of acute pancreatitis among patients with leptospirosis requiring extracorporeal membrane oxygenation (ECMO): a descriptive study
Authors: Madrigal Tristan Paulo R , Panlilio Mara Teresa T , Burog Aldrich Ivan Lois D , Danguilan Romina A , Chavez Joselito R 
Published: March 2023

BackgroundAcute pancreatitis (AP) is an infrequently reported manifestation of leptospirosis. It is more commonly seen in patients with acute respiratory distress syndrome. Despite novel modalities such as extracorporeal membrane oxygenation (ECMO), the mortality rate remains high and whether this is associated with the lung injury caused by the inflammation in AP remains unclear.Objectives and methodsA descriptive study was conducted at a tertiary hospital in the Philippines. Primary outcome was defined as the presence or absence of AP. Secondary outcomes were defined as 28-day mortality rate, length of hospital stay, ECMO days, renal replacement therapy (RRT) days, days on mechanical ventilation, presence of local complications of AP and development of nosocomial infections.ResultsA total of 27 patients were included in the study, and 88.89% (n=24) were men. The mean age for all patients was 33.59±10.22 years. Out of the 27 patients, 19 (70.37%) were diagnosed with AP. Among these 19 patients, one (5.26%) had necrotising pancreatitis and two (10.52%) developed local complications of pancreatitis. Six patients (31.58%) died among those who developed AP, while one (12.50%) died among those who did not. The duration of hospital stay, ECMO, RRT, mechanical ventilation and development of nosocomial infections was also higher in the group who presented with AP.ConclusionAP is an under-reported complication of leptospirosis. Our study demonstrated a higher mortality and morbidity in patients with leptospirosis who developed AP.
Impact ofHelicobacter pylorion the gastric microbiome in patients with chronic gastritis: a systematic review and meta-analysis protocol
Authors: Cao Xinyuan , Yang Yingyun , Zhang Yizhen , Ji Ruoyu , Zhao Xinyu , Zheng Weiyang , Yang Aiming 
Published: March 2023

IntroductionChronic gastritis is a common disease worldwide. Studies have consistently shown that chronic gastritis is usually associated with gastric microbial dysbiosis, especially the infection ofHelicobacter pylori. However, the interaction betweenH. pyloriand non-H. pyloribacteria in patients with chronic gastritis has not been clearly identified yet. Consequently, we designed a protocol for a systematic review and meta-analysis, which focused on identifying the changes in gastrointestinal microbiota composition between patients withH. pylori-infective and non-infective chronic gastritis.Method and analysisWe will search PubMed, EMBASE and Cochrane Library databases to retrieve observational studies on humans. The eligible studies must include data about the relative abundance of the gastrointestinal microbiome in patients withH. pylori-infective or non-infective chronic gastritis. Only the data of adults aged over 18 years will be analysed. Two researchers will extract the data independently, and Newcastle–Ottawa Scale will be used to assess the risk of bias. Random-effects model will be performed in quantitative analyses. Correlation analysis, bioinformatics analysis and function analysis will be performed.DiscussionCurrently, numerous studies have revealed the role ofH. pyloriin chronic gastritis. However, the alterations of non-H. pyloribacteria in patients with chronic gastritis remain an open question. The results of our study might provide new insights into future diagnosis and treatments.Ethics and disseminationThis study is based on published documents, unrelated to personal data, so ethical approval is not in need. The results of this study are expected to be published in journals or conference proceedings.PROSPERO registration numberCRD42020205260; Pre-results.
Factors influencing influenza, pneumococcal and shingles vaccine uptake and refusal in older adults: a population-based cross-sectional study in England
Authors: Tan Pui San , Patone Martina , Clift Ashley Kieran , Dambha-Miller Hajira , Saatci Defne , Ranger Tom A , Garriga Cesar , Zaccardi Francesco , Shah Baiju R , Coupland Carol , Griffin Simon J , Khunti Kamlesh , Hippisley-Cox Julia 
Published: March 2023

ObjectivesUptake of influenza, pneumococcal and shingles vaccines in older adults vary across regions and socioeconomic backgrounds. In this study, we study the coverage and factors associated with vaccination uptake, as well as refusal in the unvaccinated population and their associations with ethnicity, deprivation, household size and health conditions.Design, setting and participantsThis is a cross-sectional study of adults aged 65 years or older in England, using a large primary care database. Associations of vaccine uptake and refusal in the unvaccinated with ethnicity, deprivation, household size and health conditions were modelled using multivariable logistic regression.Outcome measureInfluenza, pneumococcal and shingles vaccine uptake and refusal (in the unvaccinated).ResultsThis study included 2 054 463 patients from 1318 general practices. 1 711 465 (83.3%) received at least one influenza vaccine, 1 391 228 (67.7%) pneumococcal vaccine and 690 783 (53.4%) shingles vaccine. Compared with White ethnicity, influenza vaccine uptake was lower in Chinese (OR 0.49; 95% CI 0.45 to 0.53), ‘Other ethnic’ groups (0.63; 95% CI 0.60 to 0.65), black Caribbean (0.68; 95% CI 0.64 to 0.71) and black African (0.72; 95% CI 0.68 to 0.77). There was generally lower vaccination uptake among more deprived individuals, people living in larger household sizes (three or more persons) and those with fewer health conditions. Among those who were unvaccinated, higher odds of refusal were associated with the black Caribbean ethnic group and marginally with increased deprivation, but not associated with higher refusal in those living in large households or those with lesser health conditions.ConclusionCertain ethnic minority groups, deprived populations, large households and 'healthier' individuals were less likely to receive a vaccine, although higher refusal was only associated with ethnicity and deprivation but not larger households nor healthier individuals. Understanding these may inform tailored public health messaging to different communities for equitable implementation of vaccination programmes.
Contribution of coping style to the association between illness uncertainty and demoralisation in patients with breast cancer: a cross-sectional mediation analysis
Authors: Hao Ran , Zhang Meng , Zuo Jinfan , Qi Yixin , Hu Jie 
Published: March 2023

ObjectiveDemoralisation is a common psychological issue in patients with cancer and aggravates depression, reduces the quality of life and even causes suicidal ideation. There is a lack of knowledge about illness uncertainty, coping style and demoralisation in patients with breast cancer. The current study explored the relationship between illness uncertainty and demoralisation among those patients, as well as the potential mediating role of coping style.DesignA cross-sectional study.SettingParticipants were recruited from the Breast Tumor Center in a tertiary hospital in Shijiazhuang, Hebei province.ParticipantsA total of 211 patients with breast cancer completed the survey.Outcome measuresA total of 211 patients with breast cancer completed the Mishel’s Uncertainty in Illness Scale, Trait Coping Style Questionnaire and the Mandarin version of Demoralization Scale (DS-MV).ResultsOf the patients, 47.40% exhibited symptoms of demoralisation (DS-MV>30), and the mean of demoralisation score was (29.55±13.21). The results demonstrated that illness uncertainty and negative coping styles were positively related to demoralisation (p<0.001), while active coping styles were negatively related to demoralisation (p<0.001). Importantly, coping styles could partially mediate the relationship between illness uncertainty and demoralisation (p<0.01).ConclusionOur study illustrated that illness uncertainty was associated with demoralisation in patients with breast cancer, and coping style acted as a mediator in this relationship. The findings highlighted the critical role of reducing negative coping styles to the early prevention and efﬁcient treatment of demoralisation among those patients.