bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal timing for epinephrine administration in adult patients with out‐of‐hospital cardiac arrest: A retrospective observational study
Authors: Sakamoto Kenta , Yasuda Hideto , Shinzato Yutaro , Kishihara Yuki , Amagasa Shunsuke , Kashiura Masahiro , Moriya Takashi 
Published: January 2025

AbstractBackgroundThis study aimed to clarify the appropriate timing for epinephrine administration in adults with out‐of‐hospital cardiac arrest (OHCA), particularly those cases with nonshockable rhythms, by addressing resuscitation time bias.MethodsWe performed a retrospective observational study utilizing a multicenter OHCA registry involving 95 hospitals in Japan between June 2014 and December 2020. We included patients with OHCA and nonshockable rhythms who received epinephrine during resuscitation. The primary and secondary outcomes were favorable 30‐day neurological status and survival, respectively. A favorable neurological outcome was defined as a cerebral performance category score of 1 or 2. The time from emergency medical service (EMS) personnel contact to epinephrine administration was categorized in 5‐min intervals. We used the Fine–Gray regression to calculate the time‐dependent propensity score in each group. After risk set matching, we employed a generalized estimating equation (GEE) to adjust for within‐patient clustering.ResultsA total of 36,756 patients were included in the analysis. When involving timing variables and GEE, epinephrine administration significantly affected favorable 30‐day neurological status at 1–5 and 6–10 min, with risk ratios (RR; 95% confidence intervals [CIs]) of 9.36 (1.19–73.7) and 3.67 (1.89–7.14), respectively. Epinephrine administration significantly affected 30‐day survival at 1–5, 6–10, 11–15, and 16–20 min, with RRs (95% CIs) of 2.33 (1.41–3.85), 2.09 (1.65–2.65), 1.64 (1.32–2.05), or 1.70 (1.29–2.25), respectively.ConclusionsEpinephrine administration within 10 min of EMS personnel contact may be associated with favorable neurological outcomes in patients with OHCA and nonshockable rhythms.
What is the impact of sports‐related gambling advertising on gambling behaviour? A systematic review
Authors: McGrane Ellen , Pryce Robert , Field Matt , Gu Shangshang , Moore Esther C. , Goyder Elizabeth 
Published: January 2025

AbstractBackground and AimsGambling is a public health issue and widespread advertising of gambling products may contribute to gambling harms. Sports‐related gambling advertising includes advertising around sports games or for sports betting products. This review aimed to provide the most systematic and up‐to‐date review of the literature on the association between sports‐related gambling advertising and gambling behaviour.MethodsA systematic literature search of quantitative studies up to 13 February 2024 was undertaken following PRISMA guidelines. Inclusion criteria were quantitative studies published in the English language exploring the association between sports‐related gambling advertising and gambling behaviour. Traditional database searches (Medline, Scopus, PsychInfo, Web of Science, CINAHL and The Cochrane Library) were undertaken alongside citation, author and website searches. Studies were narratively synthesised, and the overall quality of the evidence was assessed using the Mixed Methods Appraisal Tool (MMAT).ResultsTwenty‐two studies were included in this review covering traditional, digital, direct, embedded, inducement and aggregate advertising. The majority (n = 16) of research was undertaken in Australia on adult populations. Results suggest that sports‐related gambling advertising is associated with increases in perceived, intended and actual frequency of (n = 6 studies) and expenditure on (n = 3) gambling, unplanned or unintended gambling (n = 2), the likelihood of gambling (n = 2), the likelihood of using a sponsor's product (n = 2) and, in some cases, the complexity or riskiness of bets placed (n = 2). Studies suggest that the self‐reported effect may be more pronounced in higher‐risk gamblers (n = 7). Preliminary evidence suggests that specific inducements which reduce the riskiness or cost of gambling appear to be particularly influential (n = 3). Limitations of the evidence base include the lack of standardised measures and use of observational designs.ConclusionsExposure to sports‐related gambling advertising appears to be associated with increased gambling behaviour for a wide range of advertising media. This association may be more pronounced in higher‐risk gamblers who are already at increased risk of harm.
Pandemic Im/Mobility as Opportunity: Middle‐Class Asian Migrant Women in Australia
Authors: Ang Sylvia , Song Jay , Pan Qiuping 
Published: January 2025

ABSTRACTStudies on the impact of COVID‐19 on ethnic minorities are often centred around racism and socio‐economic inequality. Accordingly, people with Asian heritage are frequently portrayed as victims, rather than as people with agency. Drawing from interviews with middle‐class Asian migrant women, we examine the various im/mobilities Asian migrant women experienced during the pandemic: in the public/private sphere, from urban to regional cities, in intimacies and as international students. Our research demonstrated how Asian female migrants empowered themselves during the pandemic by becoming mobile in multiple ways. Certainly, the study's participants did encounter immobility. However, their circumstances benefitted significantly from their middle‐class status, relatively young age and independent visa status. The study's attention to participants' lives before and during the pandemic also enabled insight into the relationality of im/mobility: how even as the pandemic immobilised many people, it could mobilise middle‐class Asian migrant women to reconfigure the pandemic as opportunity.
Determining firing temperature of clay‐based archaeological materials with FTIR absorptivity method
Authors: Gao Yi , Liu Siran , Sun Zhenfei 
Published: January 2025

AbstractFTIR analysis has been proven to be a useful tool in measuring the firing temperature of archaeological sediments and ceramics. A recent development of this method is the finding of a negative correlation between absorptivity of 1030 cm−1 band and the firing temperatures. With potassium ferricyanide (K3[Fe (CN)6]) added as an internal standard, the 1030 cm−1 absorptivity can be measured quantitatively to reflect firing temperature of samples. However, the following investigations show that the 1030 cm−1 absorptivity can also be influenced by a series of other factors including homogeneity of sample, the mixing duration between sample, internal standard, and KBr, as well as grinding time of sample and internal standard. This research quantifies the influence of these factors and recommends the best practice for using this method. The heat‐induced absorptivity change of characteristic bands of archaeological clay‐based materials is then monitored, revealing that 1030 cm−1 band was the most optimal temperature indicator. Based on a series of Kruskal‐Wallis one‐way analyses, it is determined that for samples fired over 400°C, the absorptivity ratio of 1030 cm−1/778 cm−1 can be used to estimate its original firing temperature. However, for those fired below 400°C, K3[Fe (CN)6] has to be added and the ratio of 1030 cm−1/2117 cm−1 is more proper for quantifying its original firing temperature. The sediments from two different sites were then artificially fired to varied temperatures and tested following the analytical protocol established in this research. The results demonstrate the high accuracy of this method and its great potential in future study of ancient pyrotechnologies.
Para‐aminopropiophenone toxicity in domestic dogs: a description of non‐target toxicosis in Victoria, Australia: 13 dogs (2016–2023)
Authors: Llewellyn R , Cotela J , Lauinger C , Blevins M , Tudor A , Ray M , Ciaravolo S , Tudor E 
Published: January 2025

BackgroundPAPP is widely used in Australia as a potent vertebrate bait, with potential for off‐target ingestion and poisoning in domestic dogs. Whilst toxicosis and resulting methaemoglobinaemia is anecdotally known to occur, this is the first description in the literature. This study reports thirteen clinical cases of suspected Para‐aminopropiophenone (PAPP) toxicity in dogs, with the aim of describing clinical presentation and current management of toxicosis in this species.Case reportThree veterinary clinics in Victoria provided records of dogs where PAPP toxicity was the likely diagnosis (considering regional exposure, historical information and clinicopathological findings). Pertinent case data was described, and inferences made, based on commonalities and differences. Acute collapse, vomiting and cyanotic or brown mucous membranes were the most common presenting complaints. Marker beads associated with bait were identified in stomach contents from two dogs. All dogs received intravenous methylene blue (MB) with a mean initial dose of 3.8 mg/kg. A higher initial dose of MB (5mg/kg) was associated with a more rapid decline in methaemoglobin concentration. The mean hospitalisation time was 1.6 days with a 77% survival to discharge.ConclusionsThis case series enhances our understanding of the clinical presentation of PAPP toxicity in dogs, and response to treatment with MB. It highlights the consideration of PAPP toxicosis based on clinicopathological findings, even when definitive ingestion (i.e. presence of marker beads) cannot be established. Furthermore, it contributes to our knowledge of MB administration and suggests a fair prognosis for survival of PAPP toxicosis with prompt recognition and treatment.
Pre‐disability resilience and well‐being following the onset of functional impairments
Authors: Spooner Mikaela , Elliott Timothy R. , Luo Wen , Lee Kelly M. , Williamson Meredith L. C. 
Published: January 2025

AbstractObjectivesTested the prospective relationship of a resilient personality prototype determined prior to disability onset to well‐being among persons with and without debilitating functional impairments nine to 10 years later. A resilient profile was expected to predict well‐being through its beneficial associations with positive affect, perceived control and social support.DesignLongitudinal, prospective observation study.MethodsData obtained from participants with no functional impairments at the first assessment of the Midlife in the United States (MIDUS) project and who participated in the second survey (1147 men, 985 women at Time 1). Cluster analysis was used to create personality profiles at the first time point. Differences between resilient and non‐resilient individuals were examined. A structural equation model (SEM) tested the prospective effects of resilience on positive affect, perceived control and social support to well‐being.ResultsA resilient personality profile was identified, as expected (n = 877). Individuals with a resilient personality prototype reported higher social support, positive affect, perceived control, life satisfaction and self‐rated health at both measurement occasions than the non‐resilient group. The SEM revealed that a resilient prototype operated through the three mediating variables to prospectively predict life satisfaction, and through social support and positive affect to predict self‐rated health. These effects were independent of gender and disability severity.ConclusionsA resilient personality profile prospectively operates through positive affect, perceived control and social support to predict well‐being following the onset of debilitating impairments. The theoretical and clinical implications of these findings are discussed, and limitations are considered.
Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial
Authors: El Issaoui Meryam , Elmelund Marlene , Klarskov Niels 
Published: January 2025

ObjectivesTo evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder.Patients and MethodsThis single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for BTX‐A injections at our outpatient urogynaecology clinic between September 2022 and May 2024. Patients were randomly assigned (1:1) to receive either alkalinised lidocaine or placebo during the first treatment period. Alkalinised lidocaine solution comprised lidocaine hydrochloride (20 mg/mL, 20 mL), sodium hydrogen carbonate (1 mmoL/mL, 10 mL), and sodium chloride (9 g/L, 10 mL). The matching placebo was sodium chloride (9 g/L, 40 mL). The primary outcome measure was procedural pain rated on a 100‐mm visual analogue scale (VAS). Secondary outcomes included adverse effects such as post‐void residual urine volumes requiring catheterisation, urinary tract infection, haematuria 1 week after treatment, and patient satisfaction measured on a 5‐point scale. During the second treatment period, patients received the alternative intervention.ResultsWe enrolled 50 patients, of which 41 were eligible for per‐protocol analyses. The mean VAS score was significantly lower following intravesical alkalinised lidocaine (mean 21.3 mm, 95% confidence interval [CI] 14.7–27.8 mm) compared to placebo (mean 41.6 mm, 95% CI 35.0–48.1 mm) with a mean difference of −20.3 mm (95% CI −29.2 to −11.5 mm; P < 0.001). Adverse events and patient satisfaction did not significantly differ between the alkalinised lidocaine and placebo treatments (P = 0.825 and P = 0.138, respectively).ConclusionsIntravesical instillation of alkalinised lidocaine before BTX‐A injections significantly reduced VAS pain scores compared to placebo (ClinicalTrials.gov identifier: NCT05415865).
Activation of δ‐opioid receptors blocks allodynia in a model of headache induced by PACAP
Authors: Mangutov Elizaveta , Dripps Isaac , Siegersma Kendra , Zhang Yanping , Bocian Rebecca , Asif Sarah , Halbesma Timothy , Witkowski Wiktor , Pradhan Amynah A. 
Published: January 2025

Background and purposePituitary adenylate cyclase activating polypeptide (PACAP) is a human migraine trigger that is being targeted for migraine. The δ‐opioid receptor (δ‐receptor) is a novel target for the treatment of migraine, but its mechanism remains unclear. The goals of this study were to develop a mouse PACAP‐headache model using clinically significant doses of PACAP; determine the effects of δ‐receptor activation in this model; and investigate the co‐expression of δ‐receptors, PACAP and PACAP‐PAC1 receptor.Experimental approachCephalic allodynia to low doses of acute and chronic PACAP were tested. A triptan (sumatriptan) and a CGRP receptor antagonist (olcegepant) were tested in this model. The δ‐receptor agonist SNC80 was tested in PACAP and CGRP‐induced headache models. Expression of PACAP, PAC1, CRLR and δ‐receptors was determined using in situ hybridisation.Key resultsLow doses of PACAP produced dose‐dependent acute and chronic cephalic allodynia, blocked by sumatriptan but not by olcegepant. The PAC1 antagonist (M65) did not inhibit CGRP‐induced allodynia. There was moderate co‐expression of PAC1 and CRLR transcripts in migraine‐related regions. SNC80 blocked PACAP‐ and CGRP‐induced allodynia. There was low co‐expression of PACAP and δ‐receptors in brain regions measured. However, there was high co‐expression of PAC1 and δ‐receptors in somatosensory cortex, hippocampus and trigeminal nucleus caudalis.Conclusion and implicationsWe developed a translationally significant model of PACAP‐induced headache, which was mechanistically distinct from CGRP. Activation of δ‐receptors blocked PACAP‐ and CGRP‐induced allodynia, and δ‐receptors were highly co‐expressed with the PACAP‐ergic system. Future studies will examine the functional relationship between δ‐receptors and PAC1.
Young Children's and Caregivers' Evaluations About Household Helping: Balancing the Interests of Helper and Recipient
Authors: Martinez‐Mora Marie Grace , Dahl Audun 
Published: January 2025

ABSTRACTYoung children's helping can benefit both recipient and helper. This study examined how children and caregivers incorporate helper and recipient interests in evaluations of household helping. Data were collected throughout 2022. US children 4–6 years (N = 87; 47 girls, 40 boys; 71% European American, 23% Asian American, 14% Latinx, 3% Black, 2% Native American) and their caregivers were evaluated whether and why a child in hypothetical scenarios should help their parent. Children's judgments and reasoning incorporated both child helper and parent recipient interests, whereas caregivers' evaluations weighed child interests more heavily, ORs > 0.239. Caregiver judgments about obligation predicted children's judgments. Findings suggest that perceptions of whose interests are served shape judgments and decisions around young children's everyday prosocial behaviors.
Study of the colouristic capacity of the natural annatto dye in dyeing polyester fabrics and recycled yarns
Authors: Hillesheim Crisleine Regina , Rodrigues Quethelen Elizabeth Araujo Garcez , da Silva Marcela Kotsuka , de Souza Carolina Krebs , Bertoli Sávio Leandro , Barcellos Ivonete Oliveira , Gonçalves Marcel Jefferson 
Published: January 2025

AbstractThe textile sector has been the subject of research aimed at discovering more sustainable alternatives to harmful chemicals, and coloration technologies. In this study, the colouristic capacity of the natural annatto dye was evaluated in 100% polyester (PES) fabrics and in 100% PES fabrics with recycled thread. A comparative characterisation of a dye extracted directly from annatto seeds with a commercial natural dye was also carried out. The dyeing processes were conducted with the commercial natural dye at temperatures of 105, 110 and 115°C and pH levels of 4, 4.5 and 5, following a 22 full experimental design including two axial points and triplicate in the central point. The dyed fabric samples were subjected to wash fastness and dry and wet rubbing tests, to evaluate colour quality. The results were analysed using Statistica software, and the 100% PES fabric samples with the best exhaustion values (91.9%), colour intensity (K/S) values (1.44) and satisfactory fastness values were dyed at a temperature of 117°C and pH of 4.5. Furthermore, samples with recycled PES yarn were dyed and compared with conventional PES yarn, demonstrating similar dye and fastness characteristics, as well as intense coloration.
Bronchiectasis Exacerbation Increases the Risk of Adverse Renal Outcomes—Results From a Large Territory‐Wide Cohort Study
Authors: Kwok Wang Chun , Tsui Chung Ki , Sze Him Isaac Leung , Wong Chun Ka Emmanuel , Tam Terence Chi Chun , Ho James Chung Man , Yap Desmond Yat Hin 
Published: January 2025

ABSTRACTIntroductionBronchiectasis exacerbation (BE) is associated with unfavorable sequelae in other organs such as the cardiovascular system; data regarding its impact on adverse term renal outcomes, however, is lacking.MethodsA territory‐wide retrospective cohort study was conducted in Hong Kong between 1/1/1993 and 31/12/2017. All patients with bronchiectasis followed in the public healthcare system in 2017 were classified as “Exacerbators” or “Non‐Exacerbators,” and their adverse renal outcomes (renal progression [decrease in eGFR by 30 mL/min lasted for more than 12 months during follow up], acute kidney injury [AKI], and annual rate of eGFR decline) in the ensuing 7 years were compared. Results were also analyzed in the 1:1 propensity score matched (PSM) cohort.ResultsA total of 7929 patients (1074 “Exacerbators” group and 6855 “Non‐exacerbators”) were followed for 6.2 ± 1.6 years. A total of 1570 patients (19.8%) had renal progression, and 935 (11.8%) patients developed AKI. “Exacerbators” showed significantly increased risk of renal progression (adjusted odds ratio [aOR] 1. 27 [95% CI 1.08–1.50, p = 0.003]), more rapid eGFR decline (−3.67 [−1.74 to −6.54] vs. −3.03 [−1.56 to −5.12] mL/min/1.73 m2/year, p = 0.004) and AKI (aOR 1.99; 95% CI 1.44–2.73, p < 0.001) than the “Non‐exacerbators.” Annual number of BE was associated with renal progression (aOR 1.45; 95% CI 1.22–1.72, p < 0.001) and AKI (aOR 2.00; 95% CI 1.38–2.91, p < 0.001). Results were consistent in the analysis with the PSM cohort.ConclusionsRenal progression and AKI are common among patients with bronchiectasis, and BE is an independent risk factor for adverse renal outcomes.
Integrating Model‐Informed Drug Development With AI: A Synergistic Approach to Accelerating Pharmaceutical Innovation
Authors: Raman Karthik , Kumar Rukmini , Musante Cynthia J. , Madhavan Subha 
Published: January 2025

ABSTRACTThe pharmaceutical industry constantly strives to improve drug development processes to reduce costs, increase efficiencies, and enhance therapeutic outcomes for patients. Model‐Informed Drug Development (MIDD) uses mathematical models to simulate intricate processes involved in drug absorption, distribution, metabolism, and excretion, as well as pharmacokinetics and pharmacodynamics. Artificial intelligence (AI), encompassing techniques such as machine learning, deep learning, and Generative AI, offers powerful tools and algorithms to efficiently identify meaningful patterns, correlations, and drug–target interactions from big data, enabling more accurate predictions and novel hypothesis generation. The union of MIDD with AI enables pharmaceutical researchers to optimize drug candidate selection, dosage regimens, and treatment strategies through virtual trials to help derisk drug candidates. However, several challenges, including the availability of relevant, labeled, high‐quality datasets, data privacy concerns, model interpretability, and algorithmic bias, must be carefully managed. Standardization of model architectures, data formats, and validation processes is imperative to ensure reliable and reproducible results. Moreover, regulatory agencies have recognized the need to adapt their guidelines to evaluate recommendations from AI‐enhanced MIDD methods. In conclusion, integrating model‐driven drug development with AI offers a transformative paradigm for pharmaceutical innovation. By integrating the predictive power of computational models and the data‐driven insights of AI, the synergy between these approaches has the potential to accelerate drug discovery, optimize treatment strategies, and usher in a new era of personalized medicine, benefiting patients, researchers, and the pharmaceutical industry as a whole.