bluuebunny/crossref_metadata_2025_split huggingface dataset:
Type 2 Dendritic Cells Orchestrate a Local Immune Circuit to Confer Antimetastatic Immunity
Authors: Weizman Orr-El , Luyten Sophia , Krykbaeva Irina , Song Eric , Mao Tianyang , Bosenberg Marcus , Iwasaki Akiko 
Published: March 2023

Abstract
The progression of transformed primary tumors to metastatic colonization is a lethal determinant of disease outcome. Although circulating adaptive and innate lymphocyte effector responses are required for effective antimetastatic immunity, whether tissue-resident immune circuits confer initial immunity at sites of metastatic dissemination remains ill defined. Here we examine the nature of local immune cell responses during early metastatic seeding in the lung using intracardiac injection to mimic monodispersed metastatic spread. Using syngeneic murine melanoma and colon cancer models, we demonstrate that lung-resident conventional type 2 dendritic cells (DC2) orchestrate a local immune circuit to confer host antimetastatic immunity. Tissue-specific ablation of lung DC2, and not peripheral DC populations, led to increased metastatic burden in the presence of an intact T cell and NK cell compartment. We demonstrate that DC nucleic acid sensing and transcription factors IRF3 and IRF7 signaling are required for early metastatic control and that DC2 serve as a robust source of proinflammatory cytokines in the lung. Critically, DC2 direct the local production of IFN-γ by lung-resident NK cells, which limits the initial metastatic burden. Collectively, our results highlight, to our knowledge, a novel DC2–NK cell axis that colocalizes around pioneering metastatic cells to orchestrate an early innate immune response program to limit initial metastatic burden in the lung.
Murine Cytomegalovirus Encodes a Specific Cell Surface Marker That Can Trigger Attack by NK Cells
Authors: Campbell Kerry S 
Published: March 2023

Abstract
This Pillars of Immunology article is a commentary on “Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors,” a pivotal article written by H. Arase, E. S. Mocarski, A. E. Campbell, A. B. Hill, and L. L. Lanier, and published in Science, in 2002. https://www.science.org/doi/10.1126/science.1070884.
Utilization of Virtual Learning Environment in Malaysian Non-Arabic Speaking Learners’ Classroom
Authors: Kassim Noorafini 
Published: March 2023

This study aimed to understand the utilization of VLE in Non-Arabic Speaking Learners’ classrooms from the perspective of Arabic teachers in higher education institutions. Purposive sampling was utilized to pick the research sample for this study. Then, the sample used for this study consisted of 3 Arabic language teachers. One-to-one in-depth interviews were conducted with the three informants. Semi-structured interviews were used to gather the data to allow the informants to express their experiences in an accessible manner. A case study was used in this study to create a qualitative design. The researcher used a method called thematic analysis (TA) and followed a few steps, including (i) word-by-word transcription, (ii) interview transcription, (iii) coding, and (iv) labeling. The findings illustrated the Arabic teachers’ perspectives on using VLE, the approaches when implementing VLE, and how VLE can effectively teach the Arabic language. The responses of the three informants would illustrate the main themes found using the thematic analysis (TA) method. The analysis of this study helps provide such information to universities on the perspectives of Arabic teachers on the use of VLE, their approaches when implementing VLE, and how VLE can be effective in their language teaching in a virtual learning context. This study allows us to understand better how Malaysian Arabic teachers adapt to virtual language learning environments by utilizing VLE at the university level.
Pengaruh Kelayakan Harga, Kualitas Pelayanan dan Kepercayaan Pelanggan terhadap Keputusan Pembelian pada Situs Online Tokopedia di Kota Yogyakarta
Authors: Panggo Pati Wilfridus Nong , Udayana Ida Bagus Nyoman , Hutami Tria Hatmanti 
Published: March 2023

This study aims to determine simultaneously and partially the effect of Price Eligibility, Service Quality and Customer Trust on purchasing decisions on the Tokopedia online site in the city of Yogyakarta. This study uses a type of quantitative research. The sampling technique used was non-probability sampling using purposive sampling method. The number of samples used in this study were 100 respondents, the questionnaire was used as the main data collection tool using multi linear regression. Based on the results of data analysis, it shows that the Fcount value is 22,501 with a significance of 0.000. The known Ftable with an alpha of 5% or 0.05 is 2.70. The results of these calculations indicate that Fcount > Ftable with a smaller significance than alpha, ie 0.000 < 0.05. Based on the results of the t test, it can be seen that the feasibility of price, service quality and customer trust have a simultaneous effect on Purchase Decisions on the Tokopedia online site in the city of Yogyakarta and the dominant variable on purchasing decisions is Price Eligibility.
Keywords: Price Feasibility; Service Quality; Customer Trust and Purchase Decision
Peraturan SKB 3 Mentri Mengenai Atribut Keagamaan Di Lingkungan Sekolah Sebagai bentuk Toleransi Beragama
Authors: Adetya Maulana Afdhillah Amin Adetya Maulana Afdhillah Amin Adetya Maulana Afdhillah Amin 
Published: March 2023

Surat Keputusan Bersama 3 Mentri di keluarkan oleh kementrian pendidikan dan kebudayaan, kementrian dalam negeri dan kementrian agama, dikarenakan ada polemik di sekolah SMKN 2 Padang dengan melihat kasus seorang pelajar siswi non muslim di paksa mengikuti peraturan sekolah untuk mengenakan jilbab. Pemertintah mencoba meningkatkan toleransi beragama serta saling menghormati dan SKB 3 Mentri diharpkan mampu mewujudkan sikap toleransi beragama. Dalam penelitian kali ini penulis melakukan analisis data pada sumber data yang di dapat dengan metode (Content Analysis) yang mana analisis ini akan memaparkan isi pada data secara mendalam pada sumber data yang di dapat menelusuri referensi yang terkait dengan judul penulis dengan mencari referensi digital seperti e-journal, e-book, e-document dan menganalisis dokumen yang terkait.
Upaya Meningkatkan Kompetensi Guru di Sekolah TK Maulana Nusantara terhadap Hasil Belajar Anak
Authors: Lubis Hilda Zahra , Wildani Wildani , Winanda Tiara , Pratiwi Risa Ummah , Syahpitri Anti Pebriani , Yunita Zahra , Aini Irma Qurata , Halisah Siti , Marpaung Zulham Efendi 
Published: March 2023

A nation has a responsibility to improve the quality of its human resources. Human capital is the primary investment in development in order to improve community life. This study employs quantitative descriptive research as the method of inquiry. According to the findings of the research, the teacher's strategy for increasing early childhood learning motivation in MAULANA NUSANTARA Kindergarten consists of explaining the advantages of learning, presenting fun learning, specifically learning through play, using educational game tools, allowing children to express their opinions and ideas without requiring them to agree with the teacher, always providing assistance to children, providing real learning experiences, schools holding meetings with students' parents, and teachers awarding students. giving praise or flattery, stars, merchandise, thumbs up, and the chance to travel home for the first time.
Keywords: Competence, teacher, students
Bimbingan Kelompok untuk Mengembangkan Minat Belajar Siswa SMP: Studi Kasus di Desa Karya Jadi, Kecamatan Batang Serangan
Authors: Siregar Alfin , Fitri Annisa , Assingkily Rizki , Nasution Rizky Handayani , Amalia Sinta 
Published: March 2023

Interest in learning is a desire to gain knowledge and experience towards good changes in behavior, attitudes, and the ability to interact with individuals in the community. This study provides an overview of the implementation of group guidance services in developing students' low interest in learning and the obstacles faced in implementing group guidance services in Karya Jadi Village, Batang Serangan District. The purpose of implementing group guidance services is to describe and analyze students who have a low interest in learning and provide understanding in developing student interest in learning in Karya Jadi Village, Batang Serangan District. The method used in this study is a qualitative-descriptive method. Data was obtained through three techniques; interviews, observations, and documentation studies. the results of data analysis can be concluded that interest in learning can be developed through an intense group guidance service effort carried out in a way that provides an understanding of the learning model, learning interest, and talents possessed by each student.
Keywords: Group Guidance, Learning Model, Interest in Learning, Talent.
Peran Guru Pendidikan Agama Islam Dalam Menanggulangi Dampak Negatif Media Sosial di SMAN 8 Kecamatan Mandau Kabupaten Bengkalis – Riau
Authors: Afif Nur , Nur Qowim Agus , Syah TM Rais Mujahid 
Published: March 2023

Social media has provided many conveniences in the lives of the wider community. And especially in the world of education at this time. However, there are also many problems caused by social media. The research method used is qualitative field research where the researcher conducts research by means of observation, interviews and documentation. This study aims to determine the role of Islamic religious education teachers in overcoming the negative impacts of social media. The results of the research obtained by researchers are that social media has a very bad impact on students starting from the decline in student interest in learning, many like to follow negative trends, the emergence of habits new ones that are not good for students. The role of Islamic Religious Education teachers as facilitators of overcoming the negative impacts of social media at SMAN 8 Mandua has more or less succeeded in reducing the negative impacts that arise from social media. Some of the methods used by PAI teachers are by carrying out learning outside the classroom and conducting interactive discussions in order to create a better harmonious relationship between teachers and students when they are inside or outside of teaching and learning activities. always set a good example to students, reminding him of things he should pay attention to and how he should behave in his daily social life in public, how to get along with the opposite sex and pay attention to other norms according to Islamic teachings. Programs in schools also require teachers, especially PAI teachers, to build relationships and work together with parents so that they can pay more attention and control their children when using cellphones and especially social media so that children don't spend too much time using social media.
Keywords: Role, Overcoming negative impacts, and Social Media
Analisis Lingkungan Belajar Santri Dalam Menumbuhkan Akhlak di Pondok Pesantren Daarul Muhajirin Kota Bogor
Authors: Thalabi M Sulthan Alfadly , Mulyadi Ahmad , Arif Suyudi 
Published: March 2023

In the midst of the development of globalization there are many problems from moral deviations that hit most students and affect their learning environment. The purpose of this study was to describe what learning environments were found at the Daarul Muhajirin Islamic Boarding School in Bogor City, the implementation of growing students' morals, what obstacles were found in implementing a learning environment that was in accordance with the morals of students at the Daarul Muhajirin Islamic Boarding School. This research is a qualitative field research conducted by choosing phenomenology as the approach. Data obtained via. From this study, information was obtained that the learning environment of the Daarul Muhajirin Islamic Boarding School in Bogor City had infrastructure, learning resources, learning media, and learning implementation activities. the strategy of implementing a polite learning environment climate, and the various obstacles found as well as problem solving solutions. Three important points in the implementation of a polite learning environment climate are carried out integrally, namely through learning, reverence and habituation of noble character in every santri. These three important points facilitate the creation of a climate of polite learning environment in accordance with the morals of the students at Daarul Muhajirin Islamic Boarding School.
Keywords: learning environment, students' morals
Analisis Hukum Pidana Islam dan Undang-Undang No 41 Tahun 1999 tentang Kehutanan Dalam Perkara Tindak Pidana Pembakaran Hutan:
Authors: Alwi Muhammad , Panjaitan Budi Sastera , Hasanah3 Uswatun 
Published: March 2023

A forest fire is a situation where a forest is engulfed by fire resulting in damage to the forest or forest products causing economic loss and/or environmental value. The research approach used is normative legal research, with the following conclusions: The results of this study indicate that in decision Number: 58/Pid .Sus/2016/PN Psp concerning the crime of forest burning which stated that the defendants Nelson Manurung and Muliadi Siburian had been proven guilty of committing the crime of forest fires and were sentenced to 1 (one) year in prison and a fine of Rp. 1,000,000,000 (one billion rupiah) by the Padangsidimpuan District Court. In this case it can be concluded that in their consideration the Panel of Judges did not consider the impact of the defendant's actions on the preservation of nature and the lack of firmness of the Panel of Judges in deciding cases which were considered relatively light. Criminal sanctions in the criminal act of burning forests in article 78 paragraph (3) of RI Law No. 41 of 1999 concerning forestry jo. Article 50 paragraph (3) letter d RI Law No. 41 of 1999, namely a maximum of 15 (fifteen) years and a maximum fine of Rp. 5,000,000,000 (five billion rupiah). Then, in view of Islamic criminal law, the author's findings in the criminal case of forest burning are subject to Ta'zir punishment, namely the punishment determined by the authorized government.
Keywords: criminal act, forest burning, Islamic criminal law
Moderasi Beragama dalam Prespektif Al-Qur’an dan Hadis
Authors: Aslamiyah Nur , Amalia Siswi Tri , Annisah Ayu , Mawaddah Ibnati , Darlis Ahmad 
Published: March 2023

Religious moderation is an attempt in the middle form of various existing religions. Moderation which is the middle of a group that does not really choose right or left. Islamic religious moderation is an effort in the formation of all groups in the Islamic religion which is dotted in the middle or Al-Wasth. This article refers to the Qur'an and Hadith which are the holy books of Muslims which serve as guidelines for Muslims in their daily lives. In this study, we as writers used the library research method. This is a research that collects data by retrieving data from book and journal sources. From the articles that have been presented or explained that the Al-Qur'an and Hadith do not make Muslims to do excessive or excessive extreme violence and to respect one another.
Keywords: Moderation, Religion, People
Carcinogenic and Non-carcinogenic Health Risk Assessment from Exposure of Heavy Metals in Hand Dug Wells in Gombe State
Authors: Balogun Lookman Oladimeji , Sympa Audu Haruna , Maigari Maryam Umar , Mohammed  Abdullahi Hameed , Abubakar  Dahir 
Published: March 2023

Purpose: Heavy metals are among the commonest cause of water pollution and impact human health worldwide. Therefore, this study aims to assess the probable health risk (non-carcinogenic and carcinogenic risk) for adults and children that are exposed to toxic heavy metals (Cu, Pb, Cd, Cr, Zn and Ni) through ingestion and dermal contact with dug well water in the locations.
Methodology: The hand dug wells serve as sources of drinking water, domestic and industrial purposes. In this study, composite samples from the locations were tested for the presence of heavy metals using Atomic Absorption Spectrophotometer (AAS). The health risk assessments were evaluated.
Findings: The results of the HQ values of heavy metals for combined pathways were below the safety level (HQ < 1) for adults, while the HI for children were higher than the safety limit in some stations. The average values of total carcinogenic risk index (CRI) through exposure to drinking water for children and adults were lower than 10−6. Overall, the CRI total through exposure to drinking water for children and adults are within safety level of WHO risk, negating the probability of carcinogenic risk for the children and adults to the carcinogenic elements via ingestion and dermal routes.
Recommendation: Appropriate purification, improvement in enlightenment programs and control measures should be implemented to protect the health of the residents in these localities.
IMPACTOS DA PANDEMIA DA COVID-19 SOBRE A PECUÁRIA LEITEIRA NO BRASIL / IMPACTS OF THE COVID-19 PANDEMIC ON DAIRY LIVESTOCK IN BRAZIL
Authors: Pizzio Alex , Polastrini Alessandra , Xavier Pedroza Filho Manoel , Souza Ribeiro Vinicius 
Published: March 2023

Este estudo objetivou analisar o cenário nacional da pecuária leiteira antes e durante a pandemia da COVID-19. Foram realizadas pesquisas documental e bibliográfica, bem como avaliação da especialização por meio do Quociente Locacional para os anos 2018, 2019, 2020 e 2021, cuja abrangência se estendeu em todo o território brasileiro. As análises revelaram que a pecuária leiteira nacional não foi fortemente afetada pela pandemia da COVID-19, visto que a produção, o valor da produção e outros aspectos avaliados permaneceram em patamares positivos. No que concerne à especialização dos estados, constatou-se que não houve retrocesso de estados especializados na produção de leite durante os dois anos de pandemia. Resultados similares foram confirmados por estudos realizados em diversos países em todo o mundo, que demonstraram a mesma tendência. Os resultados deste estudo sugerem que pesquisas futuras foquem e investiguem os meios de tornar as cadeias leiteiras mais resilientes.
ABSTRACT: This study aimed to analyze the national scenario of dairy farming before and during the COVID-19 pandemic. Documentary and bibliographic research were carried out, as well as an evaluation of the specialization through the Location Quotient for the Years 2018, 2019, 2020 and 2021, whose scope extended throughout the Brazilian territory. The analyzes revealed that national dairy farming was not strongly affected by the COVID-19 pandemic, as production, production value and other aspects evaluated remained at positive levels. Regarding the specialization of the states, it was found that there was no setback of states specializing in milk production during the two years of the pandemic. Similar results were confirmed by studies carried out in several countries around the world, which showed the same trend. The results of this study suggest that future research will focus on and investigate ways to make dairy chains more resilient.
DESEMPENHO DAS EXPORTAÇÕES BRASILEIRAS DE CAFÉ: APLICAÇÃO DO MÉTODO CONSTANTE MARKET-SHARE (2003-2016 / PERFORMANCE OF THE EXPORTS OF THE BRAZILIAN COFFEE INDUSTRY: APPLICATION OF THE MARKET-SHARE CONSTANT METHOD (2003-2016)
Authors: PEREIRA BRAGA FRANCISCO LAERCIO , CAMPOS KILMER COELHO 
Published: March 2023

O objetivo deste artigo foi identificar os elementos de desempenho das exportações brasileiras dos produtos do setor cafeeiro por meio do método Constant Market Share (CMS) no período (2003- 2016). Esta análise teve como base metodológica o método Constant Market-Share em três períodos: 2003 a 2008 (período I), 2009 a 2013 (período II) e 2014 a 2016 (período III). Os resultados do estudo revelaram que o efeito crescimento do comércio mundial foi fator decisivo para o desempenho das exportações desses produtos do Brasil e das regiões Sudeste e Nordeste, enquanto o efeito destino teve força negativa em todos os períodos analisados. Contudo, alguns blocos econômicos tiveram efeitos positivos, por sua vez, o que contribuiu para amenizar o resultado negativo do efeito destino total. Por fim, o efeito competitividade foi negativo para o desempenho das vendas dos produtos nos períodos II e III.

The objective of this article was to identify the performance elements of Brazilian exports of coffee products through the Constant Market Share (CMS) method in the period 2003-2016. This analysis was based on the Constant Market-Share method in three periods: 2003 to 2008 (period I), 2009 to 2013 (period II) and 2014 to 2016 (period III The results of the study showed that the growth effect of world trade was a decisive factor for the export performance of these products in Brazil and the Southeast and Northeast regions, while the destination effect had a negative effect in all the periods analyzed. However, some economic blocks had positive effects, in turn, which contributed to soften the negative result of the total destination effect. Finally, the competitiveness effect was negative for the sales performance of the products in periods II and III.
NOVÉ POZNATKY Z HYDRAULICKÉHO VÝZKUMU PRVKŮ K USMĚRNĚNÍ PROUDU ZA ROZSTŘIKOVACÍM UZÁVĚREM
Authors: Nehudek Adam , Šulc Jan 
Published: March 2023

Vzhledem k dobrým regulačním vlastnostem, relativně n.zkým pořizovacím nákladům a provozní spolehlivosti patří rozstřikovací uzávěry k nejrozšířenějším koncovým uzávěrům spodních výpust. přehrad. K zajištění bezpečného provozu vodního díla je nutné výtokový paprsek usměrnit vhodně tvarovanými usměrňovacími plochami do odpadního koryta. Článek uvádí závěry ze zkoušek usměrňovacích prvků provedených na zmenšeném hydraulickém modelu.
STUDY OF CONCRETE SAMPLES WITH VARIOUS CONTENTS OF SLAG UNDER SULPHATES ATTACK USING MATHEMATICAL APPROACH
Authors: Ondrejka Harbuľáková Vlasta , Eštoková Adriana , Kovalčíková Martina 
Published: March 2023

Mineral admixtures are used as a partial replacement for ordinary portland cement, and the progress of sulphate attack can be evaluated by several methods (pH values changes of liquid phases, loss in mass, dynamic modulus, strength, x-ray analysis, mathematical analysis). Leaching of the calcium and silicon ions from the concrete composites of various slag cement replacement (65% and 95% of slag) exposed to two different aggressive sulphate environments (sulphuric acid and magnesium sulphate) was measured by using X-ray fluorescence analysis (XRF). Consequently a statistical analysis of different media´ influence on the concrete samples deterioration was performed. The correlation between the Ca/Si leached-out masses (the same aggressive media) as well as between the concentrations of silicon and calcium each other (different aggressive media) was calculated a presented.
STANOVENÍ HYDRODYNAMICKÉHO ZATÍŽENÍ PŘELÉVANÉ MOSTOVKY POMOCÍ 2D NUMERICKÝCH SIMULACÍ
Authors: Pavlíček Michal , Špano Miroslav , Dráb Aleš 
Published: March 2023

Článek popisuje stanovení hydrodynamického zatížení přelévané mostovky, které je způsobeno prouděním vody v jejím okolí. Kvantifikace tohoto zatížení je důležitým vstupem pro statické posouzení mostní konstrukce v případech, kdy nelze vyloučit, že hladina v korytě toku dosáhne minimálně úrovně spodní hrany mostovky. V tomto případě bylo pro stanovení hydrodynamického zatížení využito modelu proudění vody s volnou hladinou ve 2D vertikální rovině, pro jehož numerické řešení byl využit software ANSYS Fluent 15.0. Pro zohlednění turbulencí proudu byl aplikován standartní k-ε model. Výsledkem výpočtů jsou hodnoty horizontální silové složky hydrodynamického zatížení působící na mostovku a z ní odvozené hodnoty tvarového součinitele. Dosažené výsledky byly porovnány s již provedenými měřeními na fyzikálním modelu a s výsledky publikovanými v dostupné literatuře.