bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibrous Zr‐MOF Nanozyme Aerogels with Macro‐Nanoporous Structure for Enhanced Catalytic Hydrolysis of Organophosphate Toxins
Authors: Ma Kaikai , Cheung Yuk Ha , Kirlikovali Kent O. , Xie Haomiao , Idrees Karam B. , Wang Xiaoliang , Islamoglu Timur , Xin John H. , Farha Omar K. 
Published: June 2023

AbstractMetal–organic frameworks (MOFs) with Lewis acid catalytic sites, such as zirconium‐based MOFs (Zr‐MOFs), comprise a growing class of phosphatase‐like nanozymes that can degrade toxic organophosphate pesticides and nerve agents. Rationally engineering and shaping MOFs from as‐synthesized powders into hierarchically porous monoliths is essential for their use in emerging applications, such as filters for air and water purification and personal protection gear. However, several challenges still limit the production of practical MOF composites, including the need for sophisticated reaction conditions, low MOF catalyst loadings in the resulting composites, and poor accessibility to MOF‐based active sites. To overcome these limitations, a rapid synthesis method is developed to introduce Zr‐MOF nanozyme coating into cellulose nanofibers, resulting in the formation of processable monolithic aerogel composites with high MOF loadings. These composites contain Zr‐MOF nanozymes embedded in the structure, and hierarchical macro‐micro porosity enables excellent accessibility to catalytic active sites. This multifaceted rational design strategy, including the selection of a MOF with many catalytic sites, fine‐tuning the coating morphology, and the fabrication of a hierarchically structured monolithic aerogel, renders synergistic effects toward the efficient continuous hydrolytic detoxification of organophosphorus‐based nerve agent simulants and pesticides from contaminated water.
Mechanoresponsive Drug Release from a Flexible, Tissue‐Adherent, Hybrid Hydrogel Actuator
Authors: Mendez Keegan , Whyte William , Freedman Benjamin R. , Fan Yiling , Varela Claudia E. , Singh Manisha , Cintron-Cruz Juan C. , Rothenbücher Sandra E. , Li Jianyu , Mooney David J. , Roche Ellen T. 
Published: June 2023

AbstractSoft robotic technologies for therapeutic biomedical applications require conformal and atraumatic tissue coupling that is amenable to dynamic loading for effective drug delivery or tissue stimulation. This intimate and sustained contact offers vast therapeutic opportunities for localized drug release. Herein, a new class of hybrid hydrogel actuator (HHA) that facilitates enhanced drug delivery is introduced. The multi‐material soft actuator can elicit a tunable mechanoresponsive release of charged drug from its alginate/acrylamide hydrogel layer with temporal control. Dosing control parameters include actuation magnitude, frequency, and duration. The actuator can safely adhere to tissue via a flexible, drug‐permeable adhesive bond that can withstand dynamic device actuation. Conformal adhesion of the hybrid hydrogel actuator to tissue leads to improved mechanoresponsive spatial delivery of the drug. Future integration of this hybrid hydrogel actuator with other soft robotic assistive technologies can enable a synergistic, multi‐pronged treatment approach for the treatment of disease.
A Direct Silver‐Catalyzed Three‐Component Approach to Trifluoromethylated Cyanopyrazoles and Cyanopyrazolines
Authors: Kumar Anuj , Mathew Shintu , Jamali Muhammad Fahad , Ahamad Shakir , Kant Ruchir , Mohanan Kishor 
Published: June 2023

AbstractA three‐component strategy for the synthesis of an important class of trifluoromethylated cyanopyrazoles from aldehydes, malononitrile and trifluorodiazoethane is reported. This approach involves a domino Knoevenagel condensation/1,3‐dipolar cycloaddition/dehydrocyanation process. Surprisingly, the use of cyanoacetate in place of malononitrile resulted in the formation of trifluoromethylated cyanopyrazolines. The protocol provides access to a wide variety of trisubstituted pyrazoles and pyrazolines thus expanding the chemical space for these structural units.
Self‐Illuminating NIR‐II Chemiluminescence Nanosensor for In Vivo Tracking H2O2 Fluctuation
Authors: Zhang Shiyi , Yuan Hao , Sun Shengchun , Qin Chunlian , Qiu Qiming , Feng Yuyan , Liu Yongjie , Li Yang , Xu Lizhou , Ying Yibin , Qi Ji , Wang Yixian 
Published: June 2023

AbstractChemiluminescence (CL) imaging, as an excitation‐free technique, exhibits a markedly improved signal‐to‐noise ratio (SNR) owing to the absence of an excitation light source and autofluorescence interference. However, conventional chemiluminescence imaging generally focuses on the visible and first near‐infrared (NIR‐I) regions, which hinders high‐performance biological imaging due to strong tissue scattering and absorption. To address the issue, self‐luminescent NIR‐II CL nanoprobes with a second near‐infrared (NIR‐II) luminescence in the presence of hydrogen peroxide are rationally designed. A cascade energy transfer, including chemiluminescence resonance energy transfer (CRET) from the chemiluminescent substrate to NIR‐I organic molecules and Förster resonance energy transfer (FRET) from NIR‐I organic molecules to NIR‐II organic molecules, occurs in the nanoprobes, contributing to NIR‐II light with great efficiency and good tissue penetration depth. Based on excellent selectivity, high sensitivity to hydrogen peroxide, and long‐lasting luminescence performance, the NIR‐II CL nanoprobes are applied to detect inflammation in mice, showing a 7.4‐fold enhancement in SNR compared with that of fluorescence.
NNaTaO3@Ta3N5 Core‐Shell Heterojunction with Controlled Interface Boosts Photocatalytic Overall Water Splitting
Authors: Lu Kejian , Xue Fei , Liu Feng , Li Mengfan , Fu Wenlong , Peng Hao , Zhang Chunyang , Huang Jie , Gao Ze , Huang Hongwen , Liu Maochang 
Published: June 2023

AbstractTa3N5 is a promising material for photocatalytic hydrogen production from water because of its suitable band structure for both solar energy collection and overall water splitting, while its application is restricted by severe charge recombination as well as non‐equilibrium redox capabilities. Herein, atomic‐scale N‐doped NaTaO3@Ta3N5 (NNaTaO3@Ta3N5) core‐shell cubes prepared by nitridation of cubic NaTaO3 are reported. The core‐shell heterojunction cubes present efficient and stoichiometric evolution of H2 and O2 from photocatalytic overall water splitting, with a quantum efficiency of 2.18% at 550 nm without any cocatalyst. The success relies on the Ta3N5 shell having a thickness of only ≈5 nm which enables increased lifetimes of the photogenerated charges. Moreover, the core‐shell heterojunction shows a type‐I band alignment that can steer smooth charge flow from NNaTaO3 to Ta3N5, particularly with the assistance of the shared communal Ta atoms at the interface. This efficiency can be further improved to 6.28% by in situ deposition of a Rh@Cr2O3 core‐shell cocatalyst, which is among the highest reported values over Ta3N5‐based photocatalyst. This study offers a promising pathway for the construction of well‐defined heterojunctions with manipulated charge transfer behavior for photocatalytic overall water splitting.
Inferring the population history of Kyrgyz in Xinjiang, Northwest China from genome‐wide array genotyping
Authors: Halili Bubibatima , Yang Xiaomin , Wang Rui , Zhu Kongyang , Hai Xiangjun , Wang Chuan‐Chao 
Published: June 2023

AbstractObjectivesXinjiang plays a vital role in the trans‐Eurasian population migration, language diffusion, and culture and technology exchange. However, the underrepresentation of Xinjiang's genomes has hindered a more comprehensive understanding of Xinjiang's genetic structure and population history.Materials and MethodsWe collected and genotyped 70 southern Xinjiang's Kyrgyz (SXJK) individuals and combined the data with modern and ancient Eurasians published. We used allele‐frequency methods, including PCA, ADMIXTURE, f‐statistics, qpWave/qpAdm, ALDER, Treemix, and haplotype‐shared methods including shared‐IBD segments, fineSTRUCTURE, and GLOBETROTTER to unveil the fine‐scale population structure and reconstruct admixture history.ResultsWe identified genetic substructure within the SXJK population with subgroups showing different genetic affinities to West and East Eurasians. All SXJK subgroups were suggested to have close genetic relationships with surrounding Turkic‐speaking groups that is, Uyghur, Kyrgyz from north Xinjiang and Tajikistan, and Chinese Kazakh, suggesting a shared ancestry among those populations. Outgroup‐f3 and symmetrical f4 statistics showed a high genetic affinity of SXJK to present‐day Tungusic, Mongolic‐speaking populations and Ancient Northeast Asian (ANA) related groups. Allele sharing and haplotype sharing profiles revealed the east–west admixture pattern of SXJK. The qpAdm‐based admixture models showed that SXJK derived ancestry from East Eurasian (ANA and East Asian, 42.7%–83.3%) and West Eurasian (Western Steppe herders and Central Asian, 16.7%–57.3%), the recent east–west admixture event could be traced to 1000 years ago based on ALDER and GLOBETROTTER analysis.DiscussionThe high genetic affinity of SXJK to present‐day Tungusic and Mongolic‐speaking populations and short‐shared IBD segments indicated their shared common ancestry. SXJK harbored a close genetic affinity to ANA‐related populations, indicating the Northeast Asian origin of SXJK. The West and East Eurasian admixture models observed in SXJK further provided evidence of the dynamic admixture history in Xinjiang. The east–west admixture pattern and the identified ancestral makeup of SXJK suggested a genetic continuity from some Iron Age Xinjiang populations to present‐day SXJK.
Synthesis and Optoelectronic Applications of dπ–pπ Conjugated Polymers with a Di‐metallaaromatic Acceptor
Authors: Chen Shiyan , Feng Lingwei , Peng Lixia , Gao Xiang , Zhu Yongfa , Yang Liulin , Chen Dafa , Zhang Kai , Guo Xugang , Huang Fei , Xia Haiping 
Published: June 2023

AbstractThe development of conjugated polymers especially n‐type polymer semiconductors is powered by the design and synthesis of electron‐deficient building blocks. Herein, a strong acceptor building block with di‐metallaaromatic structure was designed and synthesized by connecting two electron‐deficient metallaaromatic units through a π‐conjugated bridge. Then, a double‐monomer polymerization methodology was developed for inserting it into conjugated polymer scaffolds to yield metallopolymers. The isolated well‐defined model oligomers indicated polymer structures. Kinetic studies based on nuclear magnetic resonance and ultraviolet–visible spectroscopies shed light on the polymerization process. Interestingly, the resulted metallopolymers with dπ–pπ conjugations are very promising electron transport layer materials which can boost photovoltaic performance of an organic solar cell, with power conversion efficiency up to 18.28 % based on the PM6 : EH‐HD‐4F non‐fullerene system. This work not only provides a facile route to construct metallaaromatic conjugated polymers with various functional groups, but also discovers their potential applications for the first time.
Nascent Proteomics: Chemical Tools for Monitoring Newly Synthesized Proteins
Authors: Tang Qi , Chen Xing 
Published: June 2023

AbstractCellular proteins are dynamically regulated in response to environmental stimuli. Conventional proteomics compares the entire proteome in different cellular states to identify differentially expressed proteins, which suffers from limited sensitivity for analyzing acute and subtle changes. To address this challenge, nascent proteomics has been developed, which selectively analyzes the newly synthesized proteins, thus offering a more sensitive and timely insight into the dynamic changes of the proteome. In this Minireview, we discuss recent advancements in nascent proteomics, with an emphasis on methodological developments. Also, we delve into the current challenges and provide an outlook on the future prospects of this exciting field.
Combining Carbazole Building Blocks and ν‐DABNA Heteroatom Alignment for a Double Boron‐Embedded MR‐TADF Emitter with Improved Performance
Authors: Huang Feng , Fan Xiao‐Chun , Cheng Ying‐Chun , Wu Hao , Xiong Xin , Yu Jia , Wang Kai , Zhang Xiao‐Hong 
Published: June 2023

AbstractBuilding blocks and heteroatom alignments are two determining factors in designing multiple resonance (MR)‐type thermally activated delayed fluorescence (TADF) emitters. Carbazole‐fused MR emitters, represented by CzBN derivatives, and the heteroatom alignments of ν‐DABNA are two star series of MR‐TADF emitters that show impressive performances from the aspects of building blocks and heteroatom alignments, respectively. Herein, a novel CzBN analog, Π‐CzBN, featuring ν‐DABNA heteroatom alignment is developed via facile one‐shot lithium‐free borylation. Π‐CzBN exhibits superior photophysical properties with a photoluminescence quantum yield close to 100 % and narrowband sky blue emission with a full width at half maximum (FWHM) of 16 nm/85 meV. It also gives efficient TADF properties with a small singlet‐triplet energy offset of 40 meV and a fast reverse intersystem crossing rate of 2.9×105 s−1. The optimized OLED using Π‐CzBN as the emitter achieves an exceptional external quantum efficiency of 39.3 % with a low efficiency roll‐off of 20 % at 1000 cd m−2 and a narrowband emission at 495 nm with FWHM of 21 nm/106 meV, making it one of the best reported devices based on MR emitters with comprehensive performance.
Group 14 Elements Hetero‐Difunctionalizations via Nickel‐Catalyzed Electroreductive Cross‐Coupling
Authors: Chen Haifeng , Zhu Chen , Yue Huifeng , Rueping Magnus 
Published: June 2023

AbstractThe difunctionalization of unsaturated bonds plays a vital role in the enrichment of molecular complexity. While various catalytic methods for alkene and alkyne difunctionalization have been developed in recent years, hetero‐functionalization the introduction of two different atoms has been less explored. This is mainly due to the challenges associated with achieving high chemo‐, regio‐, and stereoselectivity, especially when adding two similar atoms from the same group across unsaturated bonds. In this study, we describe a nickel‐catalyzed, three‐component reductive protocol for group 14 element hetero‐difunctionalization of 1,3‐enynes using electrochemistry. This new method is mild, selective, and general, allowing for the silyl‐, germanyl‐, and stannyl‐alkylation of enynes. Various chlorosilanes as well as chlorogermans, and chlorostannanes can be successfully used in combination with aryl/alkyl‐substituted 1,3‐enynes and primary, secondary, and tertiary alkyl bromides in the electroreductive coupling.
Anti‐inflammatory Glycocalyx‐Mimicking Nanoparticles for Colitis Treatment: Construction and In Vivo Evaluation
Authors: Yoo Dohyun , Whang Chang‐Hee , Hong Jungwoo , Kim Dohyeon , Prayogo Monica Celine , Son Youngju , Jung Wonsik , Lee Seojung , Lee Hee‐Seung , Jon Sangyong 
Published: June 2023

AbstractCommon medications for treating inflammatory bowel disease (IBD) have limited therapeutic efficacy and severe adverse effects. This underscores the urgent need for novel therapeutic approaches that can effectively target inflamed sites in the gastrointestinal tract upon oral administration, exerting potent therapeutic efficacy while minimizing systemic effects. Here, we report the construction and in vivo therapeutic evaluation of a library of anti‐inflammatory glycocalyx‐mimicking nanoparticles (designated GlyNPs) in a mouse model of IBD. The anti‐inflammatory GlyNP library was created by attaching bilirubin (BR) to a library of glycopolymers composed of random combinations of the five most naturally abundant sugars. Direct in vivo screening of 31 BR‐attached anti‐inflammatory GlyNPs via oral administration into mice with acute colitis led to identification of a candidate GlyNP capable of targeting macrophages in the inflamed colon and effectively alleviating colitis symptoms. These findings suggest that the BR‐attached GlyNP library can be used as a platform to identify anti‐inflammatory nanomedicines for various inflammatory diseases.
Covalent Organic Framework Based Crosslinked Porous Microcapsules for Enzymatic Catalysis
Authors: Feng Mengchu , Niu Ziru , Xing Chunyan , Jin Yehao , Feng Xiao , Zhang Yuanyuan , Wang Bo 
Published: June 2023

AbstractThe design of porous microcapsules with selective mass transfer and mechanical robustness for enzyme encapsulation is highly desired for biocatalysis, yet the construction remains challenging. Herein, we report the facile fabrication of porous microcapsules by assembling covalent organic framework (COF) spheres at the interfaces of emulsion droplets followed by interparticle crosslinking. The COF microcapsules could offer an enclosed aqueous environment for enzymes, with size‐selective porous shells that allow for the fast diffusion of substrates and products while excluding larger molecules such as protease. Crosslinking of COF spheres not only enhances the structural stability of capsules but also imparts enrichment effects. The enzymes encased in the COF microcapsules show enhanced activity and durability in organic media as verified in both batch reaction and continuous‐flow reaction. The COF microcapsules offer a promising platform for the encapsulation of biomacromolecules.
Gas barrier properties of polyurethane nanocomposites
Authors: Pandey Shruti , Maiti Pralay , Jana Karun K. , Rana Dipak , Aswal Vinod K. 
Published: June 2023

AbstractPolyurethane nanocomposites with varying concentration of different fillers are produced through hot melt extrusion by using nanotalc and Cloisite 30B as fillers. The TEM images show good dispersion of 30B while moderate agglomeration in nanotalc composite. The result is supported by the respective nanostructures (exfoliated in 30B vs. intercalated in nanotalc composites). A slight decrease in degradation temperature is observed but the nanocomposites are thermally stable upto 300°C. Permeability significantly decreases for nanocomposites. Young's modulus increases with increasing filler concentration while the toughness improvement exhibits a maximum at 4 and 6 wt% of 30B and nanotalc, respectively. Halpin–Tsai model is employed to predict the mechanical properties of the composites. The mechanical, thermal and gas barrier properties are better in 30B as compared to nanotalc nanocomposites, due to greater interaction in 30B nanocomposites evident from the large shift of peak position in UV–vis and FTIR measurements along with its good dispersion.
PDMS‐silica composite gas separation membranes by direct ink writing
Authors: Gutierrez Dianne B. , Caldona Eugene B. , Yang Zhenzhen , Suo Xian , Cheng Xiang , Dai Sheng , Espiritu Richard D. , Advincula Rigoberto C. 
Published: June 2023

AbstractPolydimethylsiloxane (PDMS)‐based membranes containing amine‐functionalized and unfunctionalized silica particles were fabricated via direct ink writing for CO2/N2 gas separation. The printability of the inks was evaluated by rheological measurements, while spectroscopy, microscopy, thermal measurements, and mechanical testing were employed to characterize the printed membranes. The surface morphology of the membranes revealed the absence of voids, demonstrating their suitability for gas separation. The printed membranes also exhibited desirable thermal and mechanical properties (i.e., thermal degradation temperature of 518 °C and tensile strength as high as 1.178 MPa with 529% elongation). The PDMS‐based membranes generally displayed high permeability for CO2 but slightly low selectivity for the CO2/N2 gas pair. The best‐combined permeability‐selectivity performance of 8794 barrer and selectivity of 11.64 was demonstrated by the printed PDMS membrane containing no SiO2 fillers. The inclusion of unfunctionalized SiO2 particles generally increased the membrane's gas permeability but compromised the selectivity. In contrast, membranes with amine‐functionalized silica showed improved selectivity compared to membranes containing unfunctionalized silica. Overall, the performance and characteristics offered by the PDMS/silica composite membranes demonstrated the potential of 3D printing as an economical and sustainable fabrication approach to developing materials for carbon capture applications.
Hit identification of novel small molecules interfering with MALAT1 triplex by a structure‐based virtual screening
Authors: Rocca Roberta , Polerà Nicoletta , Juli Giada , Grillone Katia , Maruca Annalisa , Di Martino Maria Teresa , Artese Anna , Amato Jussara , Pagano Bruno , Randazzo Antonio , Tagliaferri Pietrosandro , Tassone Pierfrancesco , Alcaro Stefano 
Published: June 2023

AbstractNowadays, RNA is an attractive target for the design of new small molecules with different pharmacological activities. Among several RNA molecules, long noncoding RNAs (lncRNAs) are extensively reported to be involved in cancer pathogenesis. In particular, the overexpression of lncRNA metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) plays an important role in the development of multiple myeloma (MM). Starting from the crystallographic structure of the triple‐helical stability element at the 3'‐end of MALAT1, we performed a structure‐based virtual screening of a large commercial database, previously filtered according to the drug‐like properties. After a thermodynamic analysis, we selected five compounds for the in vitro assays. Compound M5, characterized by a diazaindene scaffold, emerged as the most promising molecule enabling the destabilization of the MALAT1 triplex structure and antiproliferative activity on in vitro models of MM. M5 is proposed as a lead compound to be further optimized for improving its affinity toward MALAT1.
Climate change information seeking
Authors: Choo Chun Wei 
Published: June 2023

AbstractThis research develops and tests a model of individual intentions to actively seek information about climate change. Our premise is that the individual's intention to actively seek information about climate change would determine their knowledge of and attitudes towards climate change, and this would in turn influence how they act or change their behaviors in response to that risk. Our model identifies key cognitive, affective, and situational variables drawn from research in human information behavior and risk communication. We conducted an online survey in which 212 participants in Canada and the United States responded. The results showed that the model was able to explain more than 40% of the variance in intention to seek climate change information. Social Norms, Affective Response, and Social Trust were the most important variables in influencing intention to seek climate change information. We conclude that climate change information seeking has a strong social dimension where social norms and expectations of relevant and respected others exert a major influence, and that the individual's emotional response towards the risk of climate change is more important than the individual's cognitive perception of how much information they need on climate change.
Resilient distributed model‐free adaptive predictive control for multiarea power systems under denial of service attack
Authors: Bu Xiaodong , Dai Xisheng , Wu Jing , Ni Min 
Published: June 2023

AbstractThis paper proposes a novel load frequency control (LFC) strategy for power systems based on distributed model‐free adaptive predictive control. First, a power system dynamic model is established by the input and output signals of the power system. Then, a distributed model‐free adaptive predictive control algorithm is established for the power system under denial‐of‐service attack by the established power system dynamic model, and a predictive compensation algorithm is designed to compensate the impact of DoS attack. Based on the designed distributed model‐free adaptive predictive control algorithm, the frequency tracking error of the multiarea power system is bounded. The scheme is independent of the structure of the power system and does not need to measure any state signals of the power system, relying only on the input and output data of the power system. The results of simulations demonstrate the effectiveness and superiority of the design.