bluuebunny/crossref_metadata_2025_split huggingface dataset:
Balloon‐assisted subintimal entry (BASE) in chronic total occlusion percutaneous coronary interventions
Authors: Alexandrou Michaella , Rempakos Athanasios , Al Ogaili Ahmed , Choi James W. , Poommipanit Paul , Alaswad Khaldoon , Basir Mir B. , Davies Rhian , Benton Stewart , Jaffer Farouc A. , Chandwaney Raj H. , Azzalini Lorenzo , Kearney Kathleen E. , ElGuindy Ahmed M. , Abi Rafeh Nidal , Goktekin Omer , Gorgulu Sevket , Khatri Jaikirshan J. , Aygul Nazif , Vo Minh N. , Cincin Altug , Rangan Bavana V. , Mastrodemos Olga C. , Allana Salman S. , Sandoval Yader , Burke M. Nicholas , Brilakis Emmanouil S. 
Published: September 2023

AbstractBackgroundThere is limited data on the use of the balloon‐assisted subintimal entry (BASE) technique in chronic total occlusion (CTO) percutaneous coronary intervention (PCI).MethodsWe analyzed the baseline clinical and angiographic characteristics and outcomes of 155 CTO PCIs that utilized the BASE technique at 31 US and non‐US centers between 2016 and 2023.ResultsThe BASE technique was used in 155 (7.9%) of 1968 antegrade dissection and re‐entry (ADR) cases performed during the study period. The mean age was 66 ± 10 years, 88.9% of the patients were men, and the prevalence of diabetes (44.6%), hypertension (90.5%), and dyslipidemia (88.7%) was high. Compared with 1813 ADR cases that did not use BASE, the target vessel of the BASE cases was more commonly the RCA and less commonly the LAD. Lesions requiring BASE had longer occlusion length (42 ± 23 vs. 37 ± 23 mm, p = 0.011), higher Japanese CTO (J‐CTO) (3.4 ± 1.0 vs. 3.0 ± 1.1, p < 0.001) and PROGRESS‐CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention chronic total occlusion) (1.8 ± 1.0 vs. 1.5 ± 1.0, p = 0.008) scores, and were more likely to have proximal cap ambiguity, side branch at the proximal cap, blunt/no stump, moderate to severe calcification, and proximal tortuosity. Technical (71.6% vs. 75.5%, p = 0.334) and procedural success (71.6% vs. 72.8%, p = 0.821), as well as major adverse cardiac events (MACE) (1.3% vs. 4.1%, p = 0.124), were similar in ADR cases that used BASE and those that did not.ConclusionsThe BASE technique is used in CTOs with longer occlusion length, higher J‐CTO score, and more complex angiographic characteristics, and is associated with moderate success but also low MACE.
Enhanced antioxidant capacity of brown rice vinegar supplemented with soy residue
Authors: Park Kyungeun , Kim Yookyung 
Published: September 2023

AbstractBackground and ObjectivesThis study aimed to prepare and use soy residue as a supplement to enhance the antioxidant activities of grain vinegar, which has relatively lower antioxidant activities than fruit vinegar. Brown rice vinegar (BRV) was supplemented with 30% (BROV3) and 50% (BROV5) soy residue, respectively.FindingsAfter 3 days of alcohol fermentation, the BROVs had lower sugar content (6.43–9.4 °Brix [Bx]), alcohol content (4.47%–7.5%), and pH (3.65–3.66) but higher acidity (0.75%) than BRV (12.47 °Bx, alcohol content 11%, pH 3.72, acidity 0.66%). During 10 days of acetic fermentation, the BROVs showed higher pH (3.23–3.38) and lower acidity (4.05%–4.35%) than BRV (pH 2.88, acidity 4.86%). As the soy residue was increased, the contents of essential amino acids increased from 22.03 mg/L (BRV) to 515.27 mg/L (BROV5), but those of desirable volatile compounds decreased, and those of undesirable compounds increased. The polyphenolics, flavonoids, and isoflavone contents and 2,2‵‐diphenyl‐1‐picrylhydrazyl (DPPH) and 2, 2‐azino‐bis‐3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS)+ radical‐scavenging activities of the BROVs increased while increasing soy residue.ConclusionsAlthough soy residue addition decreased certain desirable volatile compounds and increased certain undesirable ones, overall, it improved the antioxidant activity and quality of brown rice vinegar.Significance and NoveltyThe potential of soy residue for enhancing vinegar functionality was confirmed.
Hepatocellular carcinoma with gastric adenocarcinoma treated with atezolizumab and bevacizumab
Authors: Suga Takayoshi , Kimura Yuko , Furuya Kensuke , Sato Hiroko 
Published: September 2023

Key Clinical MessageAtezolizumab and bevacizumab combination therapy might be one of the treatment options for hepatocellular carcinoma concurrent with gastric adenocarcinoma.
The First Planar, Not Twisted, Distannene − A Structural Alkene Analog. Synthesis, Isolation and X‐ray Crystallography Characterization
Authors: Bashkurov Roman , Fridman Natalia , Bravo‐Zhivotovskii Dmitry , Apeloig Yitzhak 
Published: September 2023

AbstractThe tetrasilyl‐substituted distannene, (tBu2HSi)2Sn=Sn(SiHtBu2)2 6, was synthesized by mild thermolysis (70 °C in hexane) of tris(di‐tert‐butyl‐hydridosilyl)stannane 4. The X‐ray crystallography structure of 6 reveals the following unusual structural properties: a planar geometry around both Sn atoms (Σ∡Sn=359.87°), a non‐twisted Sn=Sn double bond, and the shortest Sn=Sn double bond of 2.599 Å among all acyclic distannenes. Thus, compound 6 is the first reported distannene having a structure closely analogous to a classic alkene. Reactions of 6 with CCl4 or with 2,3‐dimethylbuta‐1,3‐diene to produce 1,2‐dichlorodistannane 9 and the [2+4] cycloadduct 10, respectively, are characteristic for a Sn=Sn double bond.
Motivational communication skills to improve motivation and adherence in cardiovascular disease prevention: A narrative review
Authors: Xu Linqi , Pinxten Wim , Vandereyt Frank , Falter Maarten , Scherrenberg Martijn , Kizilkilic Sevda Ece , Van Erum Hanne , Dendale Paul , Kindermans Hanne 
Published: September 2023

AbstractLifestyle optimization is one of the most essential components of cardiovascular disease prevention. Motivational counseling provided by health care professionals could promote lifestyle modification. The purpose of the review is to identify possible evidence‐based psychological principles that may be applicable to motivational counseling in the prevention of cardiovascular disease. These motivational communication skills promote behavioral change, improved motivation and adherence to cardiovascular disease prevention. A personal collection of the relevant publications. The review identified and summarized the previous evidence of implementation intentions, mental contrasting, placebo effect and nocebo effects and identity‐based regulations in behavior change interventions and proposed their potential application in cardiovascular disease prevention. However, it is challenging to provide real support in sustainable CVD‐risk reduction and encourage patients to implement lifestyle changes, while avoiding being unnecessarily judgmental, disrespectful of autonomy, or engaging patients in burdensome efforts that have little or no effect on the long run. Motivational communication skills have a great potential for effectuating sustainable lifestyle changes that reduce CVD‐related risks, but it is also surrounded by ethical issues that should be appropriately addressed in practice. It is key to realize that motivational communication is nothing like an algorithm that is likely to bring about sustainable lifestyle change, but a battery of interventions that requires specific expertise and long term joint efforts of patients and their team of caregivers.
Association between frailty and physical performance in older patients with heart failure
Authors: Jin Uram , Yoon Minjae , Ha Jaehyung , Lee Seung‐Hyun , Yun Doeun , Kim Ji‐Su , Oh Jaewon , Park Sungha , Lee Sang‐Hak , Kang Seok‐Min , Lee Chan Joo 
Published: September 2023

AbstractBackgroundFrailty is an issue in patients with heart failure (HF). A Korean version of the frailty scale (K‐FRAIL) has been developed.HypothesisWe aimed to analyze the relationship between the K‐FRAIL scale and physical performance in patients with HF.MethodsThis study included 142 patients with HF aged ≥65 years from a single center. Muscular fitness was assessed using the handgrip test and knee extensor strength measurement. Aerobic capacity was assessed using the cardiopulmonary exercise test and 6‐min walk test (6MWT). Frailty was assessed using the K‐FRAIL questionnaire.ResultsPeak VO2 and 6MWT scores significantly decreased as frailty worsened, but handgrip and knee extensor strength did not. In the multivariate analysis, peak VO2 (β = −.31; p = .002) and 6MWT score (β = −.38; p < .001) showed significant inverse associations with the K‐FRAIL score. Based on the receiver operating characteristic curve analysis, the cut‐off values of peak VO2 (hazard ratio, 5.08; p = .023) and 6MWT (hazard ratio, 3.99; p = .020) were independent predictors of frailty.ConclusionIn older patients with HF, physical performance correlates with the degree of frailty. The K‐FRAIL scale is correlated with the peak VO2 and 6MWT.
Zwitterionic Polymer: A New Paradigm for Protein Conjugation beyond PEG
Authors: Zeng Zhipeng , Chen Shi , Chen Yongming 
Published: September 2023

AbstractTo render protein drugs more suitable for clinical treatment, PEGylation has been widely used to ameliorate their inherent deficiencies, such as poor stability, rapid elimination in the bloodstream, and high immunogenicity. While increasingly PEGylated protein drugs have been approved by the FDA, the non‐degradability of PEG and the emergence of anti‐PEG antibodies after injection raise concerns about their cumulative chronic toxicity and long‐term therapeutic efficacy. Zwitterionic polymer, with a unique structure containing equal amounts of positively charged and negatively charged groups, shows a different hydration behavior to PEG, which may be a superior PEG alternative for protein conjugation. In this concept review, a series of features beyond that of PEGylated protein exhibited by protein‐zwitterionic polymer conjugate are discussed and some suggestions are presented for their future direction.
Prescribed curvature measure problem in hyperbolic space
Authors: Yang Fengrui 
Published: September 2023

AbstractThe problem of the prescribed curvature measure is one of the important problems in differential geometry and nonlinear partial differential equations. In this paper, we consider the prescribed curvature measure problem in the hyperbolic space. We obtain the existence of star‐shaped k‐convex bodies with prescribed (n‐k)‐th curvature measures by establishing crucial C2 regularity estimates for solutions to the corresponding fully nonlinear PDE in the hyperbolic space.
Quasi‐identifier recognition with echo chamber optimization‐based anonymization for privacy preservation of cloud storage
Authors: Jadhav Poonam Samir , Borkar Gautam M. 
Published: September 2023

SummaryThe publication of data raises several security concerns, implying that when a reputable company offers data to a third party, personal information is not needed to be revealed. The fundamental issue that led to identity leakage is the connection of quasi‐identifiers (QIDs); however, the majority of researchers overlook the identification of accurate QIDs. This study developed a privacy preservation and clustering‐based quasi‐identification model based on the Echo Chamber optimization with a Z‐mixture parameter for privacy‐preserving combined data publishing to maintain the privacy of the data. The Echo chamber optimization is used to conduct a clustering‐based quasi‐identification to find the significant attributes especially, in determining the dimension of the solutions as well as the precise QIDs using the re‐identification risk rate as the fitness function. The loss of information is greatly reduced in terms of the metrics such as normalized certainty penalty metric, average equivalent class size metric, and discernibility metric. The developed optimized clustering‐based algorithm with the privacy preservation model extensively minimizes the leakage of private information and the utilization of data is well‐maintained compared with other existing algorithms.
Influence of Coordination to Silver(I) Centers on the Activity of Heterocyclic Iodonium Salts Serving as Halogen‐Bond‐Donating Catalysts
Authors: Il'in Mikhail V. , Polonnikov Denis A. , Novikov Alexander S. , Sysoeva Alexandra A. , Safinskaya Yana V. , Bolotin Dmitrii S. 
Published: September 2023

AbstractKinetic data based on 1H NMR monitoring and computational studies indicate that in solution, pyrazole‐containing iodonium triflates and silver(I) triflate bind to each other, and such an interplay results in the decrease of the total catalytic activity of the mixture of these Lewis acids compared to the separate catalysis of the Schiff condensation, the imine–isocyanide coupling, or the nucleophilic attack on a triple carbon−carbon bond. Moreover, the kinetic data indicate that such a cooperation with the silver(I) triflate results in prevention of decomposition of the iodonium salts during the reaction progress. XRD study confirms that the pyrazole‐containing iodonium triflate coordinates to the silver(I) center via the pyrazole N atom to produce a rare example of a pentacoordinated trigonal bipyramidal dinuclear silver(I) complex featuring cationic ligands.
Refined asymptotic analysis of the two‐capacitor circuit
Authors: Sommariva Antonino M. , Dalai Marco 
Published: September 2023

SummaryA refinement of a previous asymptotic analysis of the well‐known two‐capacitor circuit is presented. It rests on some mathematical results, which allow the originally conceived regularity constraint to be replaced with a new one, not only less restrictive but also and above all simpler and easier to check. On this basis, the main time domain diagrams of the circuit with the embedding switch are presented. In addition, the solution of the circuit in the transition interval is provided, and some calculations related to the distribution side of the analysis are also reconsidered and improved.
Qualification of the differential leukocyte count and immunophenotyping in cryopreserved ex vivo whole blood assay
Authors: Imbratta Claire , Gela Anele , Bilek Nicole , Mabwe Simbarashe , Cloete Yolundi , Mortensen Rasmus , Borges Álvaro H. , Maenetje Pholo , Mlotshwa Mandla , Churchyard Gavin , Sudi Lwitiho , Sabi Issa , Meewes Peter , Wallis Carole L. , Hatherill Mark , Scriba Thomas J. , Nemes Elisa 
Published: September 2023

AbstractWe developed a flow cytometry‐based assay, termed Differential Leukocyte Counting and Immunophenotyping in Cryopreserved Ex vivo whole blood (DLC‐ICE), that allows quantification of absolute counts and frequencies of leukocyte subsets and measures expression of activation, phenotypic and functional markers. We evaluated the performance of the DLC‐ICE assay by determining inter‐operator variability for processing fresh whole blood (WB) from healthy donors collected at multiple clinical sites. In addition, we assessed inter‐operator variability for staining of fixed cells and robustness across different anticoagulants. Accuracy was evaluated by comparing DLC‐ICE measurements to real‐time cell enumeration using an accredited hematology analyzer. Finally, we developed and tested the performance of a 27‐colour immunophenotyping panel on cryopreserved fixed WB and compared results to matched fresh WB. Overall, we observed <20% variability in absolute counts and frequencies of granulocytes, monocytes and lymphocytes (T, B and NK cells) when fresh WB was collected in different anti‐coagulant tubes, processed or stained by independent operators. Absolute cell counts measured across operators and anti‐coagulants using the DLC‐ICE method exhibited excellent correlation with the reference method, complete blood count (CBC) with differential, measured using a hematology analyzer (r2 > 0.9 for majority of measurements). A comparison of leukocyte immunophenotyping on fresh WB versus DLC‐ICE processed blood yielded equivalent and linear results over a wide dynamic range (r2 = 0.94 over 10–104 cells/μL). These results demonstrate low variability across trained operators, high robustness, linearity and accuracy, supporting utility of the DLC‐ICE assay for large cohort studies involving multiple clinical research sites.
Lesser Prairie‐chicken incubation behavior and nest success most influenced by nest vegetation structure
Authors: Gehrt Jacquelyn M. , Sullins Daniel S. , Verheijen Bram H. F. , Haukos David A. 
Published: September 2023

AbstractIncubation breaks are necessary for any nesting bird but can increase the mortality risk of the nest or attending parent. How intrinsic and extrinsic variables affect nest attentiveness—the proportion of time a female is on nest during incubation— and subsequent survival of the nest remains unclear for uniparental species. We related female nest attentiveness to nest survival and tested the effects of intrinsic and extrinsic variables on nest attentiveness by female Lesser Prairie‐chickens (Tympanuchus pallidicinctus) using GPS locations of 87 females at 109 nest sites in 3 study areas in Kansas during 2013–2015. Daily nest survival increased by 39% when nest attentiveness increased from 21% to 98%. Female Lesser Prairie‐chickens were 18% less attentive as body mass increased from 600 to 920 g. Daily precipitation and temperature, controlled for days into the incubation period, had interactive effects on nest attentiveness with nest attentiveness lowest on cool, wet days and increasing as temperature increased, regardless of precipitation (41% attentiveness at 16°C and 79 mm of precipitation to 90% attentiveness at 37°C and 41 mm of precipitation). Nest attentiveness increased by 11% as the quantity of grass at the nest site increased from 5% to 78% when visual obstruction was at 1 and 2 decimeters (dm) and increased 9% as the quantity of grass at the nest site increased from 5% to 83% when visual obstruction was at its maximum (3 dm). Our findings reveal the critical importance of nest attentiveness and incubation behavior, not only in relation to demography, but within the context of changing environmental conditions. As warmer temperatures and extreme precipitation events become more common and change the growth rates of vegetation, species like the Lesser Prairie‐chicken that are ground‐nesting, rely on vegetation cover, and exhibit uniparental care could experience negative demographic consequences.
Prognostic impact of nutrition measures in patients with heart failure varies with coexisting physical frailty
Authors: Iida Yuki , Kamiya Kuniyasu , Adachi Takuji , Iwatsu Kotaro , Kamisaka Kenta , Iritani Naoki , Imoto Shota , Yamada Sumio ,   the FLAGSHIP collaborators
Published: September 2023

AbstractAimsMalnutrition is prevalent among patients with heart failure (HF); however, the effects of coexisting malnutrition and frailty on prognosis are unknown. This study examines the impact of malnutrition and frailty on the prognosis of patients with HF.Methods and resultsWe examined 1617 patients with HF aged 65 years or older (age: 78.6 ± 7.4; 44% female) from a Japanese multicentre prospective cohort study. The nutritional status was evaluated using the Geriatric Nutritional Risk Index (GNRI), Controlling Nutritional Status (CONUT), and Mini Nutritional Assessment Short Form on discharge. Frailty was assessed using the criteria determined in a previous study on patients with HF. The prognostic impact of each nutrition measure on the risk of composite all‐cause mortality and cardiac readmissions within 2 years of hospital discharge was assessed using Kaplan–Meier survival curves and Cox proportional hazards model analysis for non‐frail and frail groups. Over 2324.2 person‐years of follow‐up, 88 patients died and 448 patients experienced readmission due to HF. In the non‐frail group, poor nutritional status assessed using the GNRI and CONUT was associated with an increased hazard ratio (HR) of composite outcomes in the crude model; however, adjustment for potential confounders diminished the association. In the frail group, all three nutritional indicators were associated with the cumulative incidence of the study outcome (log‐rank test, P < 0.05). In multivariate analysis, only the CONUT score was associated with an increased HR even after adjustment for confounders.ConclusionsThe CONUT score predicted a poor prognosis in HF patients with coexisting physical frailty, highlighting the potential clinical benefit of nutritional assessment based on biochemical data for further risk stratification.
Influence of corrosion on failure modes and lifetime seismic vulnerability assessment of low‐ductility RC frames
Authors: Shekhar Shivang , Freddi Fabio , Ghosh Jayadipta , Lad Devang 
Published: September 2023

AbstractCorrosion of reinforced concrete (RC) structures constitutes a critical form of environmental deterioration and may significantly increase the vulnerability of old non‐seismically designed buildings during earthquake events. This study proposes a probabilistic framework to evaluate the influence of corrosion deterioration on the lifetime seismic fragility of low‐ductility RC frame buildings. In contrast to limited past literature on this topic, the proposed framework offers novel contributions. This is one of the first study to consider potential alteration in failure modes of building components (from flexure to flexure‐shear) due to the time‐dependent aging process. Numerical models validated with past experimental test results are utilized to capture these failure modes, which are particularly relevant for low ductility RC frames designed prior to the introduction of modern seismic codes. Secondly, given the gamut of uncertainties associated with the corrosion process, this study develops condition‐dependent seismic fragility functions independent from an assumed exposure scenario, as often done in literature. These functions can be easily adopted by design engineers and stakeholders for prompt fragility assessment, and subsequent decision‐making without the need for computationally expensive finite element (FE) model runs. The proposed framework is demonstrated on a benchmark three‐story RC frame that considers time‐varying seismic demand models and damage state thresholds while accounting for the uncertain corrosion deterioration process and ground motion record‐to‐record variability.
The role of ammonia as an alternative fuel by mixing it into natural gas and satisfying the gas quality requirements
Authors: Ingo Christina , Tuuf Jessica , Björklund‐Sänkiaho Margareta 
Published: September 2023

AbstractAmmonia as a carbon‐free e‐fuel has a good potential as a future energy vector to contribute to reducing greenhouse gas emissions. By mixing it into natural gas (NG), the carbon dioxide emissions are decreased when the mixture is burnt. To study the change in the gas properties of different NG compositions with and without added hydrogen, 0–20 mol% ammonia was mixed and various parameters were calculated. The results show that a higher content of ammonia decreases the compression factor, lower heating value, and Wobbe index (WI). Depending on the gas composition the relative density is either increasing, for NGs containing a high level of methane and/or hydrogen, or decreasing, for gases with larger quantities of higher hydrocarbons and/or inert gases. NGs with added hydrogen are more impacted by addition of ammonia, where the relative density can be improved by mixing the gas with ammonia to satisfy the gas quality requirements. However, taking the WI limits into account, more ammonia can be added into a NG without any hydrogen compared to one with hydrogen. The addition of ammonia into NG is possible considering the gas quality parameters, even in the case when the gas contains some hydrogen.