bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable innovation: Additive manufacturing and the emergence of a cyclical take‐make‐transmigrate process at a pioneering industry–university collaboration
Authors: Rose James R. , Bharadwaj Neeraj 
Published: March 2023

AbstractInnovation experts posit that digital technologies—such as additive manufacturing (AM)—can address societal challenges and change the nature of work and collaboration. In recognition, this special issue encourages researchers to investigate how AM can be leveraged to reduce environmental externalities and devote greater attention to the production of 3D printed items. This article integrates academic research on new product development and the cradle‐to‐cradle philosophy with insights gleaned from long‐term case observations across a series of large‐scale AM projects to advance that 3D printing can unleash three pivotal adaptations to the traditional conception‐development‐launch ecosystem. Specifically, our direct participation in designing and building multiple 3D printed products reveals that: (1) spent products can possess valuable ingredient materials that can be repurposed, (2) the reduced structural strength of the reclaimed material can be a positive force insofar as spawning innovation in a new product category, and (3) manufacturing should appear as an independent stage in new product development. On this last point, our completed projects align with recent observations that newer AM technologies can make prototyping and manufacturing products easier, faster, and less expensive. Accordingly, we advance a cyclical sustainable innovation process, which consists of ideation, development, AM output (i.e., manufacturing), and material reclamation. This research is both theoretically meaningful and pragmatically useful. It addresses knowledge gaps regarding AM in the academic literature and spawns new research questions for innovation scholars. For managers, it provides a path to supplant the wasteful take‐make‐dispose production model with the more efficient and effective take‐make‐transmigrate approach that we deem an innovation loop. Specifically, our final built project—a 3D designed and printed chair that uses polymers from the spent chassis of a 3D printed car—serves as a proof of concept that AM can be a catalyst to a paradigmatic shift in how products are made.
Rural US residents recognize anxiety better than urbanites and suburbanites but hold similar stigma
Authors: Loveridge Scott , Skidmore Mark , Shupp Robert , Miller Paula K. , Cuthbertson Courtney , Goetz Stephan 
Published: March 2023

AbstractPurposeRecognizing signs of psychological distress is a critical first step in assisting people who are struggling with poor mental health to access help. However, community‐level factors that impact recognition and stigma are underexplored. The purpose of this study is to investigate the relationship between rurality, other community‐level variables, and individual variables with regard to the recognition and stigma of anxiety.MethodsWe use a survey of US adults (N = 627), including a rural oversample, and a cloaked vignette approach. We assess the ability to identify anxiety and measure associated stigma. The analysis applies an ecological model in multinomial logistic regressions.FindingsAbout half of the respondents recognize anxiety from a list of possibilities when provided with a vignette detailing common anxiety symptoms. Respondents living in rural areas are nearly twice as likely to correctly identify anxiety than nonrural respondents. About one‐fifth of respondents agree with a statement designed to measure stigma: that exhibiting the symptoms is a sign of personal weakness. Respondents able to identify anxiety show less stigma. Respondents from counties with high mental health provider access were less likely to endorse the stigma statement.ConclusionsRural areas seem poised to reduce the stigma associated with anxiety, because residents are more adept at identifying anxiety than people living elsewhere. Future work could focus on effective mechanisms for reducing stigma associated with anxiety in rural areas, and whether anxiety recognition and stigma are changing.
Antibiotics “dumped”: Negotiating Pharmaceutical Identities, Properties, and Interests in China–India Trade Disputes
Authors: Zhang Mingyuan , Bjerke Lise 
Published: March 2023

AbstractChina and India have become major producers of antibiotics, and the world has become highly dependent on them. Since 2000, the competition among Chinese and Indian manufacturers on key antibiotic ingredients has become increasingly intense in a series of trade disputes involving anti‐dumping investigations. Analyzing these trade disputes, we find that they provide a space of communication and contestation where seemingly objective facts about pharmaceutical ingredients are transformed into debatable subjects, which are used and sometimes manipulated by stakeholders of conflicting interests. The disputes reveal entangled configurations and multilayered stakes in the China–India pharmaceutical nexus that often defy polarized national interests. Stakeholders must juggle multiple factors, including public health interests, nationalist sentiments, and corporate profit, in negotiating the national identities and the physical and chemical properties of “standard” pharmaceutical ingredients. The disputes also highlight the coexistence of collaboration and competition among Chinese and Indian stakeholders in global pharmaceutical supply chains. [antibiotics, active pharmaceutical ingredients (APIs), pharmaceutical nexus, dumping, trade disputes, China–India]
The Belly's Word: Domestic Violence in a Bengali Clinic
Authors: Maitra Amrapali 
Published: March 2023

AbstractUnspeakability is a dominant analytic lens in scholarship on gendered violence in India, but women can and do speak out. This article examines how Bengali women complain about domestic violence throughpeter katha, the belly's word. The capaciouspet(belly) is the seat of tension, where abuse dwells in the body. At a clinic in Kolkata, India, women describe sensations of abdominal pain, pressure, and hunger to convey patterns and temporalities of violence. Yet complaints of belly pain go unacknowledged by local clinicians. Hygiene discourses frame poor women's bodies, not structural violence, as the problem.Peter kathais more than an idiom of distress: it is a genre of embodied complaint that illuminates violence as the accrual of harm and, in its dynamic and layered quality, moves beyond a binary of disclosure or concealment. Anthropologists may usepeter kathato extend the conceptual vocabulary of gender and silence. [domestic violence, kinship, complaint, hygiene, belly, India]
Trait‐based assembly of arbuscular mycorrhizal fungal communities determines soil carbon formation and retention
Authors: Horsch Caitlyn C. A. , Antunes Pedro M. , Fahey Catherine , Grandy A. Stuart , Kallenbach Cynthia M. 
Published: March 2023

Summary

Fungi are crucial for soil organic carbon (SOC) formation, especially for the more persistent mineral‐associated organic C (MAOC) pool. Yet, evidence for this often overlooks arbuscular mycorrhizal fungi (AMF) communities and how their composition and traits impact SOC accumulation.

We grew sudangrass with AMF communities representing different traits conserved at the family level: competitors, from the Gigasporaceae family; ruderals, from the Glomeraceae family; or both families combined. We labeled sudangrass with 13C‐CO2 to assess AMF contributions to SOC, impacts on SOC priming, and fungal biomass persistence in MAOC.

Single‐family AMF communities decreased total SOC by 13.8%, likely due to fungal priming. Despite net SOC losses, all AMF communities contributed fungal C to soil but only the Glomeraceae community initially contributed to MAOC. After a month of decomposition, both the Glomeraceae and mixed‐family communities contributed to MAOC formation. Plant phosphorus uptake, but not hyphal chemistry, was positively related to AMF soil C and MAOC accumulation.

Arbuscular mycorrhizal fungi contribution to MAOC is dependent on the specific traits of the AMF community and related to phosphorus uptake. These findings provide insight into how variations in AMF community composition and traits, and thus processes like environmental filtering of AMF, may impact SOC accumulation.
Accelerating action to reduce anemia: Review of causes and risk factors and related data needs
Authors: Hess Sonja Y. , Owais Aatekah , Jefferds Maria Elena D. , Young Melissa F. , Cahill Andrew , Rogers Lisa M. 
Published: March 2023

AbstractAnemia is a major public health concern. Young children, menstruating adolescent girls and women, and pregnant women are among the most vulnerable. Anemia is the consequence of a wide range of causes, including biological, socioeconomic, and ecological risk factors. Primary causes include: iron deficiency; inherited red blood cell disorders; infections, such as soil‐transmitted helminthiasis, schistosomiasis, and malaria; gynecological and obstetric conditions; and other chronic diseases that lead to blood loss, decreased erythropoiesis, or destruction of erythrocytes. The most vulnerable population groups in low‐ and middle‐income countries are often at the greatest risk to suffer from several of these causes simultaneously as low socioeconomic status is linked with an increased risk of anemia through multiple pathways. Targeted and effective action is needed to prevent anemia. Understanding the causes and risk factors of anemia for different population subgroups within a country guides the design and implementation of effective strategies to prevent and treat anemia. A coordinated approach across various expert groups and programs could make the best use of existing data or could help to determine when newer and more relevant data may need to be collected, especially in countries with a high anemia burden and limited information on the etiology of anemia.
A DOG’S LIFE IN THE IRON AGE OF THE SOUTHERN LEVANT: CONNECTING THE TEXTUAL AND ARCHAEOLOGICAL EVIDENCE
Authors: Sapir‐Hen Lidar , Fulton Deirdre N. 
Published: March 2023

SummaryStudies of dog remains focused on the Iron Age southern Levant generally highlight their unique nature in the archaeological context, specifically in relation to their post‐mortem exploitation. Here we review the published archaeological and textual data to evaluate the current understanding of dogs’ roles in their Iron Age settings. The analysis reveals that dogs are relatively common in the archaeological record, having been reported at 66% of sites. This study further contextualizes this presence in light of their co‐occurrence with caprine and wild taxa. The significant number of dog remains indicates that they were part of the social matrix of a village. While dogs have been viewed as ‘unclean’ or pariah, based on certain textual references in the Hebrew Bible, we assert, on the basis of the archaeological record, that they were part of the life of the village, functioning as herders, guards and occasionally hunters.
First report of glyphosate resistance in an Amaranthus palmeri population from Europe
Authors: Manicardi Alfredo , Milani Andrea , Scarabel Laura , Mora Germán , Recasens Jordi , Llenes Josep María , Montull José María , Torra Joel 
Published: March 2023

AbstractThe invasive weed Amaranthus palmeri is spreading throughout Spain, with Catalonia being one of the most affected regions. For this species, acetolactate synthase‐inhibiting herbicide‐resistant populations have been reported, and now glyphosate resistance is also suspected. Glyphosate targets and inhibits the enzyme 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), but A. palmeri has evolved different resistant mechanisms leading to plant survival. One of the most effective is the EPSPS overexpression due to copy number variation (CNV). Gene copies accumulate within the EPSPS cassette that is an extrachromosomal circular DNA displaying unique structural polymorphisms. This study aims to determine the response to glyphosate of a suspected resistant population collected from a roadside and investigate the resistance mechanism involved. The herbicide bioassay confirmed that 40% of the plants survived glyphosate applied at 540 g a.i. ha−1. No known mutations endowing glyphosate resistance were found at EPSPS amongst confirmed resistant plants, while in most of them (70%) specific molecular markers revealed the presence of the EPSPS cassette. All these results indicate that this population is glyphosate resistant and it is very likely that the EPSPS gene CNV is the main resistance mechanism. This is the first case of glyphosate resistance in A. palmeri in Europe whose introduction is likely due to importation of contaminated seed with glyphosate‐resistant Palmer amaranth from the Americas. This introduction poses a significant danger to summer crops in our continent.
Antibodies against hyaluronan oligosaccharides in xenotransplantation
Authors: Bello‐Gil Daniel , Olivera‐Ardid Sara , Tuzikov Alexander B. , Costa Cristina , Bovin Nicolai V. , Mañez Rafael 
Published: March 2023

AbstractCarbohydrate‐specific antibodies are significant mediators of xenograft rejection. This study analyzed the carbohydrate specificity of antibodies in baboons before and after xenotransplantation of organs or injection of porcine red blood cells from hDAF transgenic pigs, using a glycan array with structurally defined glycans. Antibodies against hyaluronic acid disaccharide (HA2) showed the highest reactivity at baseline and rose after xenogeneic exposure. We also investigated in the serum of baboons that underwent xenotransplantation with either hDAF or hDAF/hMCP transgenic pig organs and Lewis rats after hamster‐skin xenotransplantation the specificity of anti‐HA antibodies on a glycan microarray representing HA oligosaccharides containing from two to 40 saccharides. Notably, the HA oligosaccharides ranging from 32 to 40 saccharides exhibited the highest antibody binding intensities at baseline in baboon and rat sera. After xenotransplantation, antibodies against HA38 and HA40 in baboons, and HA32, HA34, and HA36 in rats showed the highest titer increases. The changes of anti‐HA IgM and IgG antibodies in rats after skin xenotransplantation was also confirmed by an ELISA specific for HA2, HA24, and HA85 antibodies. Thus, xenotransplantation is associated with increased antibodies against HA‐oligosaccharides, which may represent a new target for intervention.
Effects of hyperprotein diet on anxiety, haemodynamics and morphofunctional aspects of the heart of Wistar rats
Authors: de Souza Flander Diego , Fidale Thiago Montes , Pereira Talita Cristina Rodrigues , Mantovani Matheus Matioli , Deconte Simone Ramos , Moreira‐Silva Daniel , de Moura Francyelle Borges Rosa , Martins Letícia de Queiroz , Alex dos Santos Luciano , Medeiros Robson da Silva , Neto Marcos Luiz Ferreira , Resende Elmiro Santos 
Published: March 2023

AbstractAnxiety is a mechanism preparatory to a response in situations of threat and danger, involving behavioural, affective and physiological factors. Protein‐based foods have a high concentration of amino acids which perform multiple functions, including in the biosynthesis of excitatory transmitters for the central nervous system. In recent years, adherence to high‐protein diets has been gaining ground in society, on the basis that it brings benefits to the musculoskeletal system and cardiovascular health. The aim of the present study was to investigate the effect of a high‐protein diet in a state of anxiety and to investigate morphofunctional cardiovascular effects of a high‐protein diet in Wistar rats. The experiment lasted 8 weeks and two groups of male rats were submitted to either a normoproteic or a hyperproteic diet. Anxiety was assessed using the plus maze test and cardiovascular morphofunctional aspects using transthoracic echocardiography and invasive measurements of femoral blood pressure. There was no statistically significant difference in the anxiety test, but the hyperproteic group was more agitated, with greater displacement during the test. Changes were found in systolic and end‐diastolic volume, left ventricular diameter in systole and heart rate, which were significantly lower in the hyperproteic group, and there was an increase in the thickness of the interventricular septum in diastole. The results showed no influence of the higher protein diet on the animals’ anxiety, body weight and haemodynamics.
Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review
Authors: Mansilla-Rodríguez María Elena , Romero-Jimenez Manuel J , Rigabert Sánchez-Junco Alina , Gutierrez-Cortizo Eva Nadiedja , Sánchez-Ramos José Luis , Mata Pedro , Pang Jing , Watts Gerald F 
Published: March 2023

IntroductionHeterozygous familial hypercholesterolaemia (heFH) is the most common monogenic cause of premature atherosclerotic cardiovascular disease. The precise diagnosis of heFH is established by genetic testing. This systematic review will investigate the risk factors that predict cardiovascular events in patients with a genetic diagnosis of heFH.Methods and analysisOur literature search will cover publications from database inception until June 2023. We will undertake a search of CINAHL (trial), clinicalKey, Cochrane Library, DynaMed, Embase, Espacenet, Experiments (trial), Fisterra, ÍnDICEs CSIC, LILACS, LISTA, Medline, Micromedex, NEJM Resident 360, OpenDissertations, PEDro, Trip Database, PubPsych, Scopus, TESEO, UpToDate, Web of Science and the grey literature for eligible studies. We will screen the title, abstract and full-text papers for potential inclusion and assess the risk of bias. We will employ the Cochrane tool for randomised controlled trials and non-randomised clinical studies and the Newcastle–Ottawa Scale for assessing the risk of bias in observational studies. We will include full-text peer-reviewed publications, reports of a cohort/registry, case–control and cross-sectional studies, case report/series and surveys related to adults (≥18 years of age) with a genetic diagnostic heFH. The language of the searched studies will be restricted to English or Spanish. The Grading of Recommendations, Assessment, Development and Evaluation approach will be used to assess the quality of the evidence. Based on the data available, the authors will determine whether the data can be pooled in meta-analyses.Ethics and disseminationAll data will be extracted from published literature. Hence, ethical approval and patient informed consent are not required. The findings of the systematic review will be submitted for publication in a peer-reviewed journal and presentation at international conferences.PROSPERO registration numberCRD42022304273.
Risk factors associated with cognitive impairment in patients with COVID-19: a protocol of systematic review and meta-analysis
Authors: Jiao Bo , Chen Mingyuan , Li Shuanger , Jiang Yingying , Chen Chan , Zhu Tao 
Published: March 2023

IntroductionCOVID-19 infections have become a global public health emergency. Although COVID-19 is primarily a respiratory disease, some of hospitalised patients exhibit cognitive impairment-related neurological damage. Using a systematic review and meta-analysis, we aim to investigate the risk factors for cognitive impairment in patients with COVID-19.Methods and analysisThis meta-analysis has been registered with the International Prospective Register of Systematic Reviews. From inception to 5 August 2022, we will search PubMed, Web of Science, Embase via Ovid, the Chinese Biological Medical Database and the Cochrane Central Register of Controlled Trials (CENTRAL) for relevant studies . We will also look for additional studies in the reference lists of selected articles. To ensure data quality and accuracy, only researches published in English and Chinese will be included. Fixed or random-effects model will be used to calculate the relative risk (RR) or odds ratio (OR) and 95% CIs for pooled data about dichotomous outcomes. We will also assess heterogeneity using Cochrane’s Q and I2tests. Cognitive impairment RR or OR is the primary outcome.Ethics and disseminationData will be extracted from published studies, so ethical approval is not required. The outcomes of this meta-analysis will be published in a journal with peer review.PROSPERO registration numberCRD42022351011.
Cognitive and mental fatigue in chronic pain: cognitive functions, emotional aspects, biomarkers and neuronal correlates—protocol for a descriptive cross-sectional study
Authors: Möller Marika C , Berginström Nils , Ghafouri Bijar , Holmqvist Anna , Löfgren Monika , Nordin Love , Stålnacke Britt-Marie 
Published: March 2023

IntroductionChronic pain (CP) is one of the most frequently presenting conditions in health care and many patients with CP report mental fatigue and a decline in cognitive functioning. However, the underlying mechanisms are still unknown.Methods and analysisThis study protocol describes a cross-sectional study aimed at investigating the presence of self-rated mental fatigue, objectively measured cognitive fatigability and executive functions and their relation to other cognitive functions, inflammatory biomarkers and brain connectivity in patients with CP. We will control for pain-related factors such as pain intensity and secondary factors such as sleep disturbances and psychological well-being. Two hundred patients 18–50 years with CP will be recruited for a neuropsychological investigation at two outpatient study centres in Sweden. The patients are compared with 36 healthy controls. Of these, 36 patients and 36 controls will undergo blood sampling for inflammatory markers, and of these, 24 female patients and 22 female controls, between 18 and 45 years, will undergo an functional MRI investigation. Primary outcomes are cognitive fatigability, executive inhibition, imaging and inflammatory markers. Secondary outcomes include self-rated fatigue, verbal fluency and working memory. The study provides an approach to study fatigue and cognitive functions in CP with objective measurements and may demonstrate new models of fatigue and cognition in CP.Ethics and disseminationThe study has been approved by the Swedish Ethics Review Board (Dnr 2018/424-31; 2018/1235–32; 2018/2395–32; 2019–66148; 2022-02838-02). All patients gave written informed consent to participate in the study. The study findings will be disseminated through publications in journals within the fields of pain, neuropsychology and rehabilitation. Results will be spread at relevant national and international conferences, meetings and expert forums. The results will be shared with user organisations and their members as well as relevant policymakers.Trial registration numberNCT05452915.