bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zonotopal Algebras, Orbit Harmonics, and Donaldson–Thomas Invariants of Symmetric Quivers
Authors: Reineke Markus , Rhoades Brendon , Tewari Vasu 
Published: March 2023

Abstract
We apply the method of orbit harmonics to the set of break divisors and orientable divisors on graphs to obtain the central and external zonotopal algebras, respectively. We then relate a construction of Efimov in the context of cohomological Hall algebras to the central zonotopal algebra of a graph $G_{Q,\gamma }$ constructed from a symmetric quiver $Q$ with enough loops and a dimension vector $\gamma $. This provides a concrete combinatorial perspective on the former work, allowing us to identify the quantum Donaldson–Thomas (DT) invariants as the Hilbert series of the space of $S_{\gamma }$-invariants of the Postnikov–Shapiro slim subgraph space attached to $G_{Q,\gamma }$. The connection with orbit harmonics in turn allows us to give a manifestly nonnegative combinatorial interpretation to numerical DT invariants as the number of $S_{\gamma }$-orbits under the permutation action on the set of break divisors on $G$. We conclude with several representation-theoretic consequences, whose combinatorial ramifications may be of independent interest.
Methods Regimes in Global Governance: The Politics of Evidence-Making in Global Health
Authors: Littoz-Monnet Annabelle , Uribe Juanita 
Published: March 2023

AbstractThis article opens up the blackbox through which evidence is selected and assessed in the making of guidelines and recommendations in global governance, through an exploration of “methods regimes.” Methods regimes are a special kind of sociomaterial arrangement, which govern the production and validation of knowledge, by establishing a clear hierachy between alternative forms of research designs. When such regimes become inscribed in processes of global governance, they shape and control what knowledge is deemed valid and thus relevant for policy. We shed light that through a mode of operation that relies on a discourse of procedurality, a dispersed but powerful network of epistemic operators, and a dense web of infrastructures, methods regimes constitute and police the making of “policy-relevant knowledge” in global governance. Through an examination of the case of “GRADE” (Grading of Recommendations, Assessment, Development, and Evaluation), a standardized system that evaluates and grades the quality of evidence in global health, we show that its dominance has worked to the effect of empowering a new cast of methodologists, seen as more objective and portable across domains, sidelining certain forms of evidence that do not conform with its own methodological criteria of scientificity, and “clinicalizing” research in medicine and beyond.
Penicillin-allergy delabelling resources for clinicians practicing in resource-limited settings: a full educational resource review of the grey literature
Authors: Staicu Mary L , Jeffres Meghan N , Jones Bruce M , Stover Kayla R , Wagner Jamie L , Bland Christopher M 
Published: March 2023

AbstractBackgroundThe clinical and financial consequences associated with a penicillin-allergy label are increasingly evident and have garnered support from international organizations to prioritize penicillin-allergy delabelling programmes. Most settings lack access to resources including drug allergy specialists and rely on general practitioners (GPs) and pharmacists.ObjectivesThe aim of this scoping review was to identify and describe freely available penicillin-allergy delabelling materials to guide clinicians practising in resource-limited settings with initiative application.MethodsThis scoping review searched two grey literature databases, six targeted websites and consulted content experts to identify freely available materials in the English language that provided evidence-based and actionable penicillin-allergy delabelling strategies. Study investigators ranked and voted on which screened resources should be included in the final review. Characteristics of resources were evaluated and compared.ResultsOut of 1191 total citations, 6 open-access resources were included. Penicillin-allergy toolkits featuring various delabelling strategies were identified in four resources. The toolkits supported a broad range of downloadable and adaptable materials, predominantly targeted towards GPs. Patient educational materials were also provided. Another resource highlighted a point-of-care penicillin-allergy risk assessment calculator via a free mobile app that quickly and accurately identified low-risk penicillin-allergic patients. The final resource, a supplemental instructional video, presented impactful and standardized delabelling strategies that clinicians can adopt into daily practices.ConclusionsLimited penicillin-allergy delabelling materials are available in the grey literature but existing resources provide broad and diverse opportunities. Additional support from health protection agencies is critical to augment ongoing delabelling efforts.
Integrating health disparities content into health informatics courses: a cross-sectional survey study and recommendations
Authors: Chen Annie T , Backonja Uba , Cato Kenrick 
Published: March 2023

AbstractObjectiveTo assess the extent to which health disparities content is integrated in multidisciplinary health informatics training programs and examine instructor perspectives surrounding teaching strategies and challenges, including student engagement with course material.Materials and MethodsData for this cross-sectional, descriptive study were collected between April and October 2019. Instructors of informatics courses taught in the United States were recruited via listservs and email. Eligibility was contingent on course inclusion of disparities content. Participants completed an online survey with open- and closed-ended questions to capture administrative- and teaching-related aspects of disparities education within informatics. Quantitative data were analyzed using descriptive statistics; qualitative data were analyzed using inductive coding.ResultsInvitations were sent to 141 individuals and 11 listservs. We obtained data from 23 instructors about 24 informatics courses containing health disparities content. Courses were taught primarily in graduate-level programs (n = 21, 87.5%) in informatics (n = 9, 33.3%), nursing (n = 7, 25.9%), and information science (n = 6, 22.2%). The average course covered 6.5 (range 2–13) social determinants of health; socioeconomic status and race/ethnicity (both n = 21, 87.5%) were most frequently addressed. Instructors described multiple obstacles, including lack of resources and time to cover disparities topics adequately, topic sensitivity, and student-related challenges (eg, lack of prior understanding about disparities).DiscussionA foundational and translational knowledge in health disparities is critical to a student’s ability to develop future equitable informatics solutions. Based on our findings, we provide recommendations for the intentional and required integration of health disparities-specific content in informatics curricula and competencies.
Monitoring resistance of Ostrinia nubilalis (Lepidoptera: Crambidae) in Canada to Cry toxins produced by Bt corn
Authors: Smith Jocelyn L , Farhan Yasmine 
Published: March 2023

Abstract
The first case of field-evolved resistance in European corn borer, Ostrinia nubilalis (Hübner) (Lepidoptera: Crambidae) to transgenic corn (Zea mays L.) producing a Bacillus thuringiensis (Bt) Berliner toxin was discovered in Nova Scotia, Canada in 2018. This case involved resistance to Bt corn producing Cry1Fa toxin. As a mitigation response, Bt corn hybrids producing only Cry1Fa were replaced in that region with hybrids producing two or three Bt toxins targeting O. nubilalis. In this study, we collected O. nubilalis in several corn-growing regions of Canada during 2018 to 2020 and tested their progeny for susceptibility to four Bt toxins produced by currently available Bt corn that targets O. nubilalis: Cry1Fa, Cry1Ab, Cry1A.105, and Cry2Ab. Based on toxin concentrations killing 50% of larvae from 23 field-derived strains relative to two susceptible laboratory strains, the resistance ratio was at least 10 for Cry1Fa for 12 strains (52% of strains) consisting of 10 strains from Nova Scotia, as well as strains from near Montreal, Quebec and Roseisle, Manitoba. We found low but statistically significant resistance relative to at least one of two susceptible strains for Cry1Ab (23% of strains), Cry1A.105 (45% of strains), and Cry2Ab (14% of strains), with maximum resistance ratios of 3.9, 5.8, and 2.0, respectively. These results provide key information for addressing O. nubilalis resistance to Bt corn in Canada.
Modelling annual scintillation velocity variations of FRB 20201124A
Authors: Main R A , Bethapudi S , Marthi V R , Bause M L , Li D Z , Lin H-H , Spitler L G , Wharton R S 
Published: March 2023

ABSTRACT
Compact radio sources exhibit scintillation, an interference pattern arising from propagation through inhomogeneous plasma, where scintillation patterns encode the relative distances and velocities of the source, scattering material, and Earth. In previous work, we showed that the scintillation velocity of the repeating fast radio burst (FRB) FRB20201124A could be measured by correlating burst spectrum pairs, with low values of the scintillation velocity and scattering time-scale suggesting scattering nearby the Earth at $\sim$0.4 kpc. In this work, we have measured the scintillation velocity at 10 epochs spanning 1 yr, observing an annual variation that strongly implies the screen is within the Milky Way. Modelling the annual variation with a 1D anisotropic or 2D isotropic screen results in a screen distance $d_{\mathrm{ l}} = 0.40\pm 0.04$ or $0.46\pm 0.06\,$ pc from the Earth, respectively, possibly associated with material outside of the Local Bubble or the edge of the Orion–Eridanus superbubble. Additional measurements particularly at times of low effective velocity will help probe changes in screen properties, and distinguish between screen models. Where scintillation of an FRB originates in its host galaxy or local environment, these techniques could be used to detect orbital motion, and probe the FRB’s local ionized environment.
Multiplex High-Definition Polymerase Chain Reaction Assay for the Diagnosis of Tick-borne Infections in Children
Authors: Nigrovic Lise E , Neville Desiree N , Chapman Laura , Balamuth Fran , Levas Michael N , Thompson Amy D , Kharbanda Anupam B , Gerstbrein Derek , Branda John A , Buchan Blake W ,   for Pedi Lyme Net
Published: March 2023

Abstract

Background
Ixodes scapularis ticks can carry Borrelia species as well as other pathogens that cause human disease. The frequency of tick-borne infections and coinfections in children with suspected Lyme disease is unknown, creating clinical uncertainty about the optimal approach to diagnosis.

Methods
We enrolled children aged 1–21 years presenting to 1 of 8 Pedi Lyme Net emergency departments for evaluation of Lyme disease. We selected cases with serologically or clinically diagnosed Lyme disease (erythema migrans or early neurologic disease) matched by symptoms, age, gender, and center to control subjects without Lyme disease. We tested whole blood samples collected at the time of diagnosis using a multiplex high-definition polymerase chain reaction (HDPCR) panel to identify 9 bacterial or protozoan pathogens associated with human disease. We compared the frequency of tick-borne coinfections in children with Lyme disease to matched controls.

Results
Of the 612 selected samples, 594 (97.1%) had an interpretable multiplex HDPCR result. We identified the following non-Borrelia tick-borne infections: Anaplasma phagocytophilum (2), Ehrlichia chaffeensis (1), and Babesia microti (12). Children with Lyme disease were more likely to have another tick-borne pathogen identified than matched controls (15/297 [5.1%] Lyme cases vs 0/297 [0%]; difference, 5.1% [95% confidence interval, 2.7%–8.2%]).

Conclusions
Although a substantial minority of children with Lyme disease had another tick-borne pathogen identified, either first-line Lyme disease antibiotics provided adequate treatment or the coinfection was subclinical and did not require specific treatment. Further studies are needed to establish the optimal approach to testing for tick-borne coinfections in children.
Interdisciplinary strategies to prevent long-term and detrimental opioid use following trauma: a stakeholder consensus study
Authors: Bérubé Mélanie , Côté Caroline , Gagnon Marc-Aurèle , Moore Lynne , Tremblay Lorraine , Turgeon Alexis F , Evans David , Berry Greg , Turcotte Valérie , Belzile Étienne L , Dale Craig , Orrantia Eli , Verret Michael , Dercksen Judy , Martel Marc-Olivier , Dupuis Sébastien , Chatillon Claude-Edouard , Lauzier François 
Published: March 2023

Abstract

Objective
Prolonged opioid use is common following traumatic injuries. Although preventive strategies have been recommended, the evidence supporting their use is low. The objectives of this study were to select interdisciplinary strategies to prevent long-term, detrimental opioid use in trauma patients for further evaluation and to identify implementation considerations.

Design
A consensus study using the nominal group technique.

Setting
Four trauma systems in Canada.

Subjects
Participants included expert clinicians and decision makers, and people with lived experience.

Methods
Participants had to discuss the relevance and implementation of 15 strategies and then rank them using a 7-point Likert scale. Implementation considerations were identified through a synthesis of discussions.

Results
A total of 41 expert stakeholders formed the nominal groups. Overall, eight strategies were favored: 1) using multimodal approach for pain management, 2) professional follow-up in physical health, 3) assessment of risk factors for opioid misuse, 4) physical stimulation, 5) downward adjustment of opioids based on patient recovery, 6) educational intervention for patients, 7) training offered to professionals on how to prescribe opioids, and 8) optimizing communication between professionals working in different settings. Discussions with expert stakeholders revealed the rationale for the selected strategies and identified issues to consider when implementing them.

Conclusion
This stakeholder consensus study identified, for further scientific study, a set of interdisciplinary strategies to promote appropriate opioid use following traumatic injuries. These strategies could ultimately decrease the burden associated with long-term opioid use.
Commissural dentate granule cell projections and their rapid formation in the adult brain
Authors: Egger Matteo , Luo Wenshu , Cruz-Ochoa Natalia , Lukacsovich David , Varga Csaba , Que Lin , Maloveczky Gyula , Winterer Jochen , Kaur Rashmit , Lukacsovich Tamás , Földy Csaba 
Published: March 2023

Abstract
Dentate granule cells (GCs) have been characterized as unilaterally projecting neurons within each hippocampus. Here, we describe a unique class, the commissural GCs, which atypically project to the contralateral hippocampus in mice. Although commissural GCs are rare in the healthy brain, their number and contralateral axon density rapidly increase in a rodent model of temporal lobe epilepsies. In this model, commissural GC axon growth appears together with the well-studied hippocampal mossy fiber sprouting and may be important for the pathomechanisms of epilepsy. Our results augment the current view on hippocampal GC diversity and demonstrate powerful activation of a commissural wiring program in the adult brain.
Closing the Conceptual Gap in Epistemic Injustice
Authors: Fürst Martina 
Published: March 2023

Abstract
Miranda Fricker’s insightful work on epistemic injustice discusses two forms of epistemic injustice—testimonial injustice and hermeneutical injustice. Hermeneutical injustice occurs when the victim lacks the interpretative resources to make sense of her experience, and this lacuna can be traced down to a structural injustice. In this paper, I provide one model of how to fill the conceptual gap in hermeneutical injustice. First, I argue that the victims possess conceptual resources to make sense of their experiences, namely phenomenal concepts. Second, I show how one might work the way up in a two-step process from a subjective, phenomenal concept to a novel, public concept. Finally, I discuss the conditions that have to be met for this process to be successful. The resulting model shows a way how the victims might alleviate hermeneutical injustice by developing novel concepts, given that the dominant group does not care about their predicament.
Delegated Learning and Contract Commonality in Asset Management
Authors: Sockin Michael , Xiaolan Mindy Z 
Published: March 2023

Abstract
We examine the pecuniary externalities that arise when active fund manager compensation contracts have common components. This commonality in the compensation structure and loadings on each component across funds reduces asset price informativeness, amplifies the distortions from active managers’ benchmark-hedging demand, and lowers the price of risk in financial markets. This is because contract commonality distorts investors’ capital allocation to active management, and active managers’ information acquisition and trading decisions. From a normative perspective, contract commonality increases the rigidity of the active industry size and performance-based fee. As a result, they do not vary enough with financial market conditions compared with a Planner’s economy. Quantitatively, an increase in asset payoff uncertainty increases the size and performance-based fee twice as much in the Planner economy compared with the decentralized economy. From a positive perspective, contract commonality contributes to the inconsistency of several widely adopted measures of active manager skill.
The evolution of an ancient tapeworm lineage in its catfish hosts: vicariance, dispersal and diversification in Gangesiinae (Cestoda: Proteocephalidae)
Authors: Marick Jit , Brabec Jan , Choudhury Anindo , Scholz Tomáš , Ash Anirban 
Published: March 2023

Abstract
The diversification of tapeworms of the subfamily Gangesiinae (Cestoda: Proteocephalidae), parasites of catfishes (order Siluriformes), is assessed using molecular and morphological evidence. A two-gene (lsrDNA and COI) phylogenetic analysis of all species of Gangesiinae (except Gangesia margolisi) resulted in a basal polytomy that included several lineages of Gangesiinae and Acanthotaeniinae. Palaeogeological events, along with host-shifting and dispersal, played prominent roles in the evolution of these tapeworms. Gangesia radiated through two major lineages in the Indomalayan and Palaearctic regions. Morphological changes during this radiation also included secondary loss of diagnostic morphological features of the genus, as in Gangesia mukutmanipurensis sp. nov., which lacks hooks and hooklets on its scolex. An updated key to the genera placed in Gangesiinae is provided and two new synonyms are proposed. A basal polytomy involving some of the potentially oldest lineages of Gangesiinae prevents firm conclusions regarding the ancestral area of origin of these tapeworms. Nevertheless, when the distribution and host-associations of Gangesiinae are considered in the context of the historical biogeography of their catfish hosts, the Indomalayan region appears to have been the ancestral homeland and a major centre of diversification of these tapeworms, with range expansions in western and northern parts of Eurasia and Africa.
Complete Genome Sequence of Bacillus velezensis Strain ZY1, a Potential Biological Control Agent for Bacterial Fruit Blotch
Authors: Ji Weiqin , Yang Yuwen , Liu Dehua , Wang Chengliang , Yu Chunyan , Guan Wei , Zhao Tingchang 
Published: March 2023

Bacillus velezensis strain ZY1 isolated from pepper leaves recently showed a strong biocontrol effect on bacterial fruit blotch. Here, we report the complete genome sequence data with annotation for Bacillus velezensis strain ZY1, which was obtained by Nanopore and Illumina sequencing technology. No gaps and plasmids were included in the sequencing results. The final assembled genome of ZY1 was 4,032,733 bp, with an average GC content of 46.42%, and it contained 3,842 prediction protein-coding genes, 86 tRNA, 27 rRNA, and 5 ncRNA. Fourteen secondary metabolite biosynthetic gene clusters were identified in the genome, which might contribute to the biocontrol function of the strain. This genome sequence provides a basis for further understanding the biocontrol mechanism of this Bacillus velezensis strain. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
N‐cadherin cleavage: A critical function that induces diabetic retinopathy fibrosis via regulation of β‐catenin translocation
Authors: Xiang Wei , Li Longhui , Hong Fuyan , Zeng Yongcheng , Zhang Jin , Xie Jinye , Shen Gang , Wang Jinhong , Fang Zhenzhen , Qi Weiwei , Yang Xia , Gao Guoquan , Zhou Ti 
Published: March 2023

AbstractRetinal fibrosis is a severe pathological change in the late stage of diabetic retinopathy and is also the leading cause of blindness. We have previously revealed that N‐cadherin was significantly increased in type 1 and type 2 diabetic mice retinas and the fibrovascular membranes from proliferative diabetic retinopathy (PDR) patients. However, whether N‐cadherin directly induces retinal fibrosis in DR and the related mechanism is unknown. Here, we investigated the pathogenic role of N‐cadherin in mediating retinal fibrosis and further explored the relevant therapeutic targets. We found that the level of N‐cadherin was significantly increased in PDR patients and STZ‐induced diabetic mice and positively correlated with the fibrotic molecules Connective Tissue Growth Factor (CTGF) and fibronectin (FN). Moreover, intravitreal injection of N‐cadherin adenovirus significantly increased the expression of FN and CTGF in normal mice retinas. Mechanistically, overexpression of N‐cadherin promotes N‐cadherin cleavage, and N‐cadherin cleavage can further induce translocation of non‐p‐β‐catenin in the nucleus and upregulation of fibrotic molecules. Furthermore, we found a novel N‐cadherin cleavage inhibitor, pigment epithelial‐derived factor (PEDF), which ameliorated the N‐cadherin cleavage and subsequent retinal fibrosis in diabetic mice. Thus, our findings provide novel evidence that elevated N‐cadherin level not only acts as a classic EMT maker but also plays a causative role in diabetic retinal fibrosis, and targeting N‐cadherin cleavage may provide a strategy to inhibit retinal fibrosis in DR patients.