bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of modified nanographene oxide loading on the swelling and compression set behavior of EPDM/SBR nano-composites
Authors: Prakash P. C. , Vishvanathperumal S. , Navaneethakrishnan V. 
Published: May 2023

AbstractNanographene oxide (GO) is used to improve the physical properties of blends of ethylene-propylene-diene monomer (EPDM) rubber/styrene-butadiene rubber (SBR) nano-composites compared with modified nanographene oxide (mGO). The modified Hummers method was used to develop the GO. GO was treated using two types of surface modifiers, 4,4'-diphenylmethane diisocyanate (MDI) and 3-Aminopropyltriethoxysilane coupling agent (KH550), and then incorporated into an EPDM/SBR rubber matrix at different concentrations, processed with an open-mill mixer, and vulcanised. The influence of mGO concentration on EPDM/SBR nanocomposites' swelling and compression set behaviour was investigated in this paper. Comparative analysis was done on the outcomes of various compositions for EPDM/SBR-GO and EPDM/SBR-mGO with nanofiller at 0, 2, 4, 6, 8 and 10 phr. In both GO-filled nanocomposites and mGO-filled nanocomposites, the increase in mGO loading is associated with a significant reduction in mole percent uptake while the compression set increases, according to the current study. In mGO-filled nanocomposites, this phenomenon is more evident than in GO-filled nanocomposites. The effect of the conditioning environment on the characteristics under investigation is clearly distinguished in this study. Swelling resistance and compression set are improved in nanocomposites containing KH550 modified GO.
Decreased interleukin-17RA expression is associated with good prognosis in patients with colorectal cancer and inhibits tumor growth and vascularity in mice
Authors: Jiang Jeng-Kai , Lin Chi-Hung , Chang Ting-An , Lo Liang-Chuan , Lin Chien-Ping , Lu Ruey-Hwa , Yang Chih-Yung 
Published: May 2023

Abstract
Background
Interleukin-17 (IL-17) is a proinflammatory cytokine that plays a vital role in the promotion of tumorigenesis in various cancers, including colorectal cancer (CRC). Based on current evidence, IL-17 binds to interleukin-17 receptor A (IL-17RA); however, the role of IL-17RA has not been elucidated in previous studies on CRC. In this study, we explored the role of IL-17RA in human CRC tissues and the progression of CRC in humans and mice.
Methods
The expressions of IL-17RA and epithelial-mesenchymal transition (EMT)-related genes were examined in CRC cells and tissue samples by quantitative real-time polymerase chain reaction. The role of IL-17RA in pathogenesis and prognosis was evaluated using a Chi-square test, Kaplan-Meier analysis, univariate and multivariate Cox regression analysis in 133 CRC patients. Murine stable IL-17RA knockdown CT-26 CRC cells were used to examine the functions of IL-17RA on cells proliferation, migration and invasion. In addition, A tumor-bearing mice model was executed to evaluate the role of IL-17RA in tumor growth, vascularity and population of infiltrating immune cells.
Results
IL-17RA expression was found to be significantly higher in CRC tissues than in adjacent normal tissues. The expression of IL-17RA in stage IV patients was significantly higher than that in stages I and II patients. Patients with high IL-17RA expression exhibited significantly worse overall and CRC-specific survival than those with low IL-17RA expression. Functional assessment suggested that the knockdown of IL-17RA expression distinctly suppressed cellular proliferation, migration, invasion, and EMT-related gene expression. In a tumor-bearing mouse model, decreased IL-17RA expression significantly repressed tumor growth and vascularity and reduced the population of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). Reduced IL-17RA expression also suppressed cellular proliferation, migration, and invasion, and the expression of EMT genes. Knockdown of IL-17RA inhibited tumor growth and vascularity and decreased the population of Tregs and MDSCs in mouse tumors.
Conclusion
Our results suggest that decrease IL-17RA expression impairs cellular proliferation, migration and invasion ability, as well as EMT gene expression. Furthermore, knockdown IL-17RA suppressed the tumor vascularity, growth and reduced the population of Tregs and MDSCs in mice tumors. In addition, IL-17RA expression was identified to be independently associated with the prognosis of patients with CRC.
A risk-scoring system for assessing prognosis in multiple myeloma patients based on a large real-world sample
Authors: Wang Yue , Yang Yang , Wang Wenjing , Li Jing , Xu Tianhong , Liu Peng 
Published: May 2023

Abstract
Objective
Multiple myeloma (MM) is an incurable malignancy with a diversity of clinical characteristics and prognoses. The commonly used staging system has obvious shortcomings. Exploring accurate prognostic models is essential.
Methods
A total of 1,276 newly diagnosed MM patients were selected from Zhongshan Hospital Fudan University between January 2010 and April 2021. After excluding patients with amyloidosis or other tumors, a total of 802 patients receiving standard first-line therapy were included. 703 patients in the non-transplant group (527 patients in the training set and 176 patients in the validation set) and 109 patients in the transplant group. We enrolled 41 baseline parameters including clinical, laboratory, and pathological features. We used univariate and multivariate Cox analyses to screen for factors associated with overall survival and to develop prognostic models.
Results
The final risk-scoring system includes ECOG score, extramedullary lesion, thrombocyte, reticulocyte, anion gap, hypercalcemia, complement C3, β2-microglobulin, cytogenetics and interleukin-2 receptor. We identify the optimal cut-off for the risk score and divide the patients into high-risk and low-risk groups. Kaplan-Meier curves and Log-rank tests showed that the risk score was significant with overall survival in the training set (P < 0.001), validation set (P < 0.001) and transplant group (P = 0.02). The time-dependent receiver operator characteristic curve shows that the risk score has a better predictive value than the commonly used staging system.
Conclusion
A novel MM risk score system is developed based on a large real-world sample. We have performed a comprehensive assessment of baseline disease characteristics, which is of high application and practice value.
Transient receptor potential-canonical channels in the nervous system
Authors: Tong Yuchen , Yang Junjing , Du Lailing 
Published: May 2023

Abstract
Transient receptor potential-canonical (TRPC) channels are non-selective cation channels, which have highly selective permeability to calcium ions. TRPC channels start to be expressed early in embryonic development and remain present until adulthood. In the brain, TRPC channels regulate the depletion of second messengers and calcium stores and are activated by a range of mechanisms. Increasing evidence suggests that TRPC channels are associated with regulating basic neural function. TRPC channels have some association with neurodevelopment, neural cell proliferation, and differentiation. In addition, TRPC channels are believed to play a relevant role in neurosecretion, LTP, and synaptic plasticity. Over the past few years, several important studies have linked TRPC channels to neurons, and constantly emphasized the decisive contribution of this group of channels in modulating neural function. In this paper, we review the role of TRPC channels in neurodevelopment, mature nervous system, and neurological diseases.
Selective serotonin reuptake inhibitors regulates the interrelation between 5-HT and inflammation after myocardial infarction
Authors: Zhang Lijun , Lu Nan , Liu Meiyan 
Published: May 2023

Abstract
This study aimed to explore the effect of escitalopram in treating a model under myocardial infarction (MI) and unpredictable chronic mild stress (UCMS). Male C57BL/6J mice were treated with sham surgery, or MI surgery, or UCMS, or escitalopram (ES) for a consecutive two weeks. And the mice were divided into Sham group, MI group, MI + UCMS group, MI + UCMS + ES group (n = 8 in each group). After treatment, the mice went through open field test for anxiety behavior, sucrose preference test for depressive behavior. After sacrificed, the blood, heart, hippocampus, and cortex were collected.The escitalopram badly increased the area of cardiac fibrosis size. The sucrose preference demonstrated that escitalopram treatment showed significant effect in improving depressive behaviors of mice under MI + UCMS. The potential mechanism involved the interrelation between 5-HT system and inflammation. MI significantly affected the level of cardiac SERT. Both UCMS and ES significantly affected the level of cortex TNF-α. UCMS significantly affect the level of cardiac IL-33. In the hippocampus tissue, TNF-α was positively correlated with SERT, and IL-10 was positively correlated with SERT. In the cortex tissue, IL-33 was positively correlated with 5-HT4R, and sST2 was positively correlated with 5-HT. Two-week escitalopram treatment might worsen myocardial infarction. But escitalopram could benefit depressive behaviors, which may be related with the interrelationship between the 5-HT system and inflammatory factors in the brain.
An Investigation on Effects of Modes of Cooling on Mechanical Property of Sn-Cu Alloy
Authors: Satyanarayan  , Raju Rajath , Algur Veerabhadrappa , M.C  , A Jayarama , Basavaraja Kusammanavar 
Published: May 2023

Abstract
63Sn–37Pb solder alloy is widely used as filler materials in electronic packaging industries. However, due to environmental and human health concern use of lead (Pb) in electronic applications is restricted. Thus, Pb−free solders are preferred in electronic packaging to replace Sn–37Pb solder. Sn–0.7Cu lead free solder alloy has attracted considerable attention. However, research works on effects of modes of cooling of Sn–0.7Cu Pb−free solder are scant. The cooling or solidification behaviour controls the metallurgical microstructure of solder alloys. To work satisfactorily in electronic packaging applications, good hardness is essential for reliability of Sn–Cu solder alloy. Hence in the current research work, the effect of casting moulds on solidification behaviour, microstructure and mechanical property (hardness) of Sn–0.7Cu alloy is assessed. Two cooling moulds mild steel (MS) and Graphite around water and two different cooling media (Furnace, air) were used for solidification to achieve different cooling modes. Further, an effect of grain morphology and hardness on Sn–0.7Cu alloy cooled in different moulds/media were assessed.
Clinical Outcomes of Robotic Posterosuperior Hepatectomy Compared to Major Hepatectomy: A Propensity Score-Matched Analysis of Liver Resection for Difficult Segments Using Robotic Platform.
Authors: Sucandy Iswanto , Patel Niritta , Syblis Cameron , Guenoun Kawtar , Crowley Marcy , Ross Sharona , Rosemurgy Alexander 
Published: May 2023

Abstract
Introduction:
Minimally invasive resection of posterosuperior hepatic segments (i.e., segments VII and VIII) is a technically challenging operation due to limited visibility and accessibility. Therefore, this type of liver resection is mainly undertaken via a traditional open approach. We aimed to analyze the safety, feasibility, and efficacy of robotic posterosuperior resection and compare them with those of robotic major hepatectomy.
Methods
128 patients undergoing robotic posterosuperior and major hepatectomy were included. Patient demographics, intra-, and postoperative outcomes were analyzed. Data are presented as median (mean ± SD).
Results
Robotic posterosuperior resection was undertaken in 32 patients, and these patients were propensity score-matched to 96 patients who underwent a robotic major hepatectomy. There were no significant differences in age, sex, BMI, past liver and abdominal operations, ASA, MELD score, Child-Pugh score, and number of patients with cirrhosis. In patients who underwent robotic posterosuperior resection versus major hepatectomy, there were no differences in the following intraoperative variables: operative duration (292 vs 281 minutes; p = 0.87), estimated blood loss (200 vs 175 mL; p = 0.32), and R1 status (0% vs 2%; p = 1.00). There were no open conversions. Postoperatively, there were no significant differences in outcomes, including Clavien-Dindo grade ≥ III complications (0% vs 4%; p = 0.57), length of stay (4 vs 4 days; p = 1.00), 30-day readmissions (22% vs 18%; p = 0.61), 30-and 90-day mortality (0% vs 1%; p = 1.00). The IWATE difficulty scores were significantly higher for the posterosuperior hepatectomies.
Conclusions
Robotic posterosuperior hepatectomy is safe, feasible, and effective with excellent clinical outcomes, similar to those of major hepatectomy.
IL-6 mediated renal tubular cell senescence via GATA2/ SERPINE1 pathway
Authors: lin xiaoxi , Sun Keke , Liu Qihui , Zhao Yibo , Zhang Yan , Shou Songtao , Chai Yanfen , Jin Heng 
Published: May 2023

Abstract
Background
Acute kidney injury due to crush syndrome is a major life-threatening complication characterized by high morbidity and mortality. The role of senescence in the progression of acute kidney injury is receiving increasing attention. Our previous study has shown that remote ischemic postconditioning can attenuate kidney cell senescence and serum IL-6 from ischemia-reperfusion injury after crush injury. This raises the question of what role IL-6 plays in the progression of CS-AKI. The aim of this study was to investigate the role of IL-6 in CS-AKI.
Methods
Hk-2 cells were treated with 150uM ferrous myoglobin to mimic CS-AKI at the cellular level. Cells were harvested after 24 hours or treated with 100ug/ml tocilizumab for another 24 hours. RNA sequencing was performed on myoglobin and tocilizumab treated cells. The cell cycle and the percentage of senescent cells were detected by flow cytometry. The expression levels of SERPINE1, GATA2, p53, p21 were detected by real-time PCR and Western blot. The binding effect of SERPINE1 and GATA2 was verified by dual luciferase gene reporter assay.
Results
RNA sequencing revealed genes down-regulated by tocilizumab in HK-2 cells, including GATA2 and SERPINE1. qPCR and Western blotting confirmed that GATA2, SERPINE1, p53 and p21 expression decreased after tocilizumab treatment. The dual luciferase gene reporter verified that GATA2 acts on the promoter of SERPINE1 (PAI-1) to initiate SERPINE1 transcription.
Conclusions
In a word, IL-6 activates the p53/ P21 pathway through GATA2/SERPINE1, which triggers senescence in CS-AKI and then promotes the progression of AKI (Fig. 1 graphical abstract).
Discovery of novel inhibitors of Indoleamine 2, 3-dioxygenase (IDO) via virtual screening and biochemical evaluation
Authors: Hao Xuanrun , Wei Minqin , Li Haining , Su Qing 
Published: May 2023

Abstract
The number of deaths from cancer is increasing worldwide every year. IDO (ndoleamine 2,3-dioxygenase) is an important target for tumour therapy. Overexpression of IDO in the tumour microenvironment leads to apoptosis of effector T-cells, resulting in tumour development. Inhibition of IDO expression has been shown to be an effective tumour therapy. Therefore, the aim of this study is to find new IDO inhibitors. Virtual screening and bioassay methods, including molecular docking, drug-like property investigation and anti-tumour evaluation, were used to search for new potential IDO inhibitors in the Specs database. A compound with potent inhibitory activity on Hela cells was found, IC50 value was 3.959 ± 0.380 µ M. By analysing the binding mechanism of the compound with IDO protein, the possible source of its activity was explained. In conclusion, this paper reports a virtual screening strategy based on molecular docking. Through this strategy, compounds with anti-tumour activity were obtained. It provides a new direction for the discovery and development of anti-tumour agents in the future.
Evolution of contact surface characteristics and tribological properties of copper-based self-lubricating composites under heavy load
Authors: Li Yongdu , Zhang Yuan , Wang Xuejun , Li Yang , Wang Xiaohong , Huang Junjie , Yang Mei 
Published: May 2023

Abstract
The composite material sintered by copper and graphite belongs to 'pseudo-alloy', which reduces its self-lubricating performance to a certain extent. Because WS2 and graphite have similar self-lubricating characteristics, the synergistic lubrication mechanism of copper-based graphite-WS2 (Cu-Gr-WS2) has become a hot research topic in recent years. In this paper, the synergistic lubrication mechanism and friction contact surface characteristics of Cu-Gr-WS2 self-lubricating composites under different friction loads were studied. The results show that the friction coefficient first decreases and then increases under the load from 20N to 110N, and the worn surface roughness first decreases and then increases. There is almost no self-lubricating film on the contact surface under small loads. With the load increasing to 80N, the friction coefficient is as low as 0.115, and a continuous and smooth graphite-WS2 self-lubricating film is formed on the contact surface. The main wear mechanism is delamination wear, and the thickness of the lubricating film is about 14.5nm by XPS etching. When the load continues to increase to 110N, there are many adhesion pits on the lubrication film of the contact surface, and the self-lubricating performance decreases.
CCA-LSTM: A Novel Hybrid Prediction Network Based on Convolutional Channel Attention Mechanism and LSTM for PM2.5 Concentration Prediction
Authors: Zhang Xiaoxia , Chen Zheng , hu Feng 
Published: May 2023

Abstract
Accurate prediction of PM2.5 is crucial for urban ecological management, and with the advancement of digital transformation, it is necessary to analyze the spatiotemporal patterns of pollutant concentrations in multiple stations jointly. However, traditional prediction models have limited ability to utilize spatial correlation in joint prediction of multiple stations, and their structure designs do not fit well with the application context of PM2.5 concentration prediction, leading to poor accuracy. On the one hand, flexible spatiotemporal dependence model-ing of multiple stations can effectively alleviate accuracy errors caused by spatial heterogeneity. On the other hand, the model structure design can be determined through classical analysis methods, and influential feature values can be determined for subsequent modeling to enhance model robustness. Based on these views, this paper proposes a corresponding data analysis process and designs a deep network based on convolution, channel attention mechanism, and LSTM (short for, CCA-LSTM) for predicting PM2.5 concentration. Specifically, we use clustering methods to select station data with high spatial correlation, then model pollutant data from both deterministic and uncertain aspects, and finally use CCA-LSTM for prediction. CCA-LSTM consists of three key components: (1) a smoothing layer for smoothing seasonal factors to enable the model to focus on learning residuals that can be described by features; (2) a multi-branch convolu-tion for learning the multi-periodicity of pollutant data; (3) a channel attention mechanism for weighting important historical time-step states. Experiments on real datasets have shown that our method outperforms five baseline methods.
Is There a Relationship Between the Severity of Disease in Major Depressive Disorder Patients and Dry Eye Disease?
Authors: Gökçe Gizem Doğan , Metin Merve 
Published: May 2023

Abstract
Purpose: To investigate dry eye disease (DED) in newly diagnosed patients with depressive disorder (MDD).Method: This observational study included 48 MDD patients in Group 1 and 20 healthy controls in Group 2. Psychiatric and ophthalmic examinations, Beck Depression Inventory (BDI), Ocular Surface Disease Index (OSDI), Schirmer's test, tear break-up time (TBUT), meibomian gland dysfunction (MGD), and ocular staining were conducted. The results were statistically compared.Results: The participants, comprising 32 men and 36 women, had a mean age of 31.08 ± 11.7 years (18–64 years). Group 1 had a mean BDI score of 30.87 ± 8.56, while Group 2 had a score of 1.3 ± 1.3 (p < 0.001). In Group 1, 28 patients were diagnosed with DED, whereas in Group 2, six patients were diagnosed with DED. The mean Schirmer's results in Group 1 and Group 2 were (mm/5min) 10.87 ± 2.44 and 12.70 ± 2.3, respectively, and were significantly lower in Group 1 (p < 0.001). The mean OSDI scores in Group 1 (34.95 ± 15.8) were significantly higher compared to Group 2 (3.2 ± 3.1) (p < 0.001). There was no significant difference in mean TBUT between Group 1 (9.41 ± 2.6 sec) and Group 2 (9.8 ± 0.61 sec) (p > 0.05). Significant correlations were found between BDI scores and Schirmer's results as well as OSDI scores (p < 0.05, p = 0.02, respectively). No statistically significant correlations were found between BDI scores and TBUT or MGD (p > 0.05).Conclusion: DED was found to be more prevalent in the MDD group. The severity of MDD and DED, as indicated by BDI, OSDI, and Schirmer's results, were found to be correlated. It was observed that patients with higher depression scores had more severe dry eye. As a result, we recommend performing ophthalmic examinations in newly diagnosed MDD patients.
The discovery of the variability of Alpha Sextantis, a non-eclipsing binary star
Authors: Hamedamen Aven M. , Murad Ismail , Murad Ismail 
Published: May 2023

Abstract
This paper presents the discovery of the variability of the main star of the Sextans constellation. The discovery was made using data from the TESS space telescope, and the analysis was done in Peranso.
Climate change impacts on Aotearoa New Zealand: a horizon scan approach
Authors: Macinnis-Ng Cate , Ziedins Ilze , Ajmal Hamza , Baisden Troy W. , Hendy Shaun , McDonald Adrian , Priestley Rebecca , Salmon Rhian A. , Sharp Emma L. , Tonkin Jonathan D. , Velarde Sandra , Watene Krushil , Godsoe William 
Published: May 2023

Abstract
Many of the implications of climate change for Aotearoa (New Zealand) remain unclear. To identify so-far unseen threats and opportunities related to climate change we applied a horizon-scanning process. First, we collated 171 threats and opportunities across our diverse fields of research. We then scored each item for novelty and potential impact and finally reduced the list to ten threats and ten opportunities through a prioritisation process. Within the 20 items presented in this paper, we uncover a range of climate-related costs and benefits. Unexpected opportunities evolve from economic reorganisation and changes to perspectives. The threats we highlight include the overall failure to interconnect siloed policy responses, as well as those relating to extreme events and feedbacks, as well pressures that undermine the coherence of society. A major theme of our work is that climate changes’ effects in Aotearoa are likely to transgress the boundaries of research disciplines, industry sectors and policy systems, emphasising the importance of developing transdisciplinary methods and approaches. We use this insight to connect potential responses to climate change with Aotearoa’s culture and geography.