bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of the Antioxidant Compounds from the Eugenol to the Lubricating Oils
Authors: Faez S. Al-Shibli  , Raed K. Al-Tamemi  , Khansa A. R. Al-Assdi  
Published: August 2023

In this study new antioxidant compounds were prepared by (thiol-ene) click chemistry, where these compounds were prepared using (1:1) mole ratio of (thiol : eugenol) in the presence of benzoyl peroxide as initiator and the reaction is carried out at (100 0C) for (9) hrs.
(FT-IR), (1HNMR), and mass spectroscopy were used to characterize the synthesized compounds. They were evaluated as antioxidants by adding compounds to base oil and lubricant oil, where they showed high antioxidant activity against lubricant oil oxidation processes.
PERAN GURU DALAM MENUMBUHKAN SIKAP NASIONALISME SISWA DI MI NAHJATUL FAIZIN KEPOHKENCONO PUCAKWANGI KABUPATEN PATI
Authors: Nurul Aisyah Firda , Dwi Ardianti Sekar , Bakhruddin Ahmad 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui bagaiman sikap nasionalisme siswa, upaya guru dalam menanamkan sikap nasionalisme dan kendala yang dihadapi guru dalam menanamkan sikap nasionalisme siswa di MI Nahjatul Faizin Kepohkencono Pucakwangi Kabupaten Pati. Penelitian ini menggunakan metode kualitatif dan pendekatan studi kasus. Hasil penelitian ini menunjukkan bahwa sikap nasionalisme siswa sudah cukup baik namun masih ada siswa yang belum bisa menerapkan sikap nasionalisme dengan baik. Upaya yang dilakukan guru yaitu dengan kegiatan akademik seperti mengaitkan pembelajaran dengan nilai-nilai nasionalisme. Sedangkan untuk non akademik dilakukan dengan cara upacara bendera dan ekstrakurikuler. Untuk kendala yang dihadapi guru yaitu kurangnya kesadaran siswa akan sikap nasionalisme, terbatasnya waktu dan sarana prasarana.
Prozessmodellierung in der additiven Fertigung/Molecular Dynamics Simulations for Improving Additive Manufactured Quality
Authors: Müller Sarah , Westkemper Engelbert , Klein Dominic , Öhlschläger Fabio , Roth Johannes 
Published: August 2023

Die Einsatzmöglichkeiten der additiven Technologie wachsen und verändern die Art und Weise wie wir produzieren. Gleichzeitig steigen die Anforderungen an die Qualität und Reproduzierbarkeit der noch jungen Technologie. Eine Möglichkeit zur Optimierung der Qualität durch Prozessmodellierung stellen Simulationen dar. Dieser Beitrag zeigt einen Ansatz zur Modellierung des additiven Prozesses mit metallischen Werkstoffen auf der Ebene eines einzelnen Pulverpartikels mittels der Molekulardynamik.

Additive applications are rising and are changing the way we will manufacture in the future. At the same time demands for quality and reproducibility are growing. A possibility for improving quality lies in the simulation of the process. This article presents an approach for modelling the additive process on the scale of a single powder particle using molecular dynamics.
REVIEW: NATURAL BIOACTIVE COMPOUNDS POTENTIAL ON INHIBITION OF TRANSMEMBRANE SERINE PROTEASE 2 WITH STRUCTURE-BASED VIRTUAL SCREENING METHOD
Authors: Nurcahyaningtyas Haviani Rizka , Putra Masteria Yunovilsa , Yanuar Arry 
Published: August 2023

The COVID-19 pandemic has led to a global health emergency. Suitable medications are required to prevent severe SARS-CoV-2 infection. Human transmembrane serine protease 2, which is required for viral entry into the host cells, was identified as the target protein. The present study was designed to synthesize, through a systematic review, evidence of phytochemicals found in plants that can inhibit transmembrane serine protease 2 in silico. The databases ScienceDirect, PubMed, Scopus, Nature, and SpringerLink were used for systematic exploration. Among the 113 studies retrieved, 11 were selected for the entire read and 7 studies were deemed appropriate for the qualitative synthesis. Flavonoids, including the bioactive substances luteolin, vicenin 2, naringin, 8-geranylapigenin, phenylethyl-D-rutinoside morusin, sanggenol L, and kaempferol, are the most widely studied classes of secondary metabolites. Other classes that were also evaluated were lactones, terpenoids, and saponins with withanoside-V, 11-hydroxy-2-(3,4-dihydroxybenzoyloxy)abieta-5,7,9(11),13-tetraene-12- one, and licorice as active substances, respectively. This review indicates the most bioactive components of each group of metabolites that demonstrated the greatest binding affinity for the transmembrane serine protease 2 receptor, as an initial point for selecting substances and exploring additional laboratory research and clinical studies to identify novel medication candidates for COVID-19 treatment.
Keywords: Secondary metabolite, SARS-CoV-2, structure-based virtual screening, transmembrane serine protease 2, Plants
Characterization of disease-associated microbiota in hepatocellular carcinoma
Authors: Sun Pengfei , Li Zhongchao , Zhang Bo 
Published: August 2023

ABSTRACT

Aims:
This study aimed to investigate the differences in the composition of microbial communities and related functions in hepatocellular carcinoma (HCC) tumours and matched normal tissues were investigated.

Methods and Material:
Tumour tissues and matched normal samples were collected from 30 HCC patients. Genomic DNA was collected and subjected to sequencing of the V3 + V4 region of the 16S rRNA gene. The microbial community profiles and metabolic pathway predictions of the different groups were characterized and compared.

Results:
Tumour and adjacent tissues had similar microbiota compositions but differed in abundance. Proteobacteria and Firmicutes abundance decreased and Cyanobacteria and Acidobacteria abundance increased in the tumour tissue. The microbial community diversity was higher in the tumour tissues than in adjacent samples, with potentially more dominant taxa in the adjacent tissues, including Firmicutes, Proteobacteria, and Actinobacteria. Acidobacteria, Cyanobacteria, and Chloroflexi were the dominant microbes in tumour tissues. A total of 46 metabolic pathways were identified. Global and overview maps were the most abundant pathways, followed by carbohydrate metabolism, energy metabolism, metabolism of cofactors and vitamins, and membrane transport. The top 50 most highly correlated microbial genera included Klebsiella, Rhodococcus, Ochrobactrum, and Azoarcus. Fonticella, Haloimpatiens, Brevibacterium, and Acidothermus were positively correlated with other microbial genera. The microbiota of adjacent tissues was more robust in the network analysis.

Conclusions:
This study revealed differences in microbial composition between HCC tumour tissues and normal tissues and differences in microbial abundance associated with different metabolic functions. Cyanobacteria, Proteobacteria, and Actinobacteria may play important roles in HCC.
Port-exposure management of totally implantable venous access ports: A case report
Authors: Liu Chunqin , Liu Xiaohua , Zhao Shunying , Li Weifeng 
Published: August 2023

ABSTRACT
Totally implantable venous access ports (TIVAP) are widely utilized in chemotherapy, parenteral nutrition, and long-lasting intravenous therapy in cancer patients. However, port exposure occurs due to skin damage around the port. Thus, managing port exposure is of great importance; however, it is full of challenges. We reported two cases of port exposure due to TIVAP. In these two patients, the catheters were inserted into the internal jugular or axillary vein under local anesthesia and ultrasound guidance and were connected to the port implanted on the ipsilateral chest through the subcutaneous tunnel. Chemotherapy and targeted drug therapy were administered using these ports. During the treatment intermission, the ports of two patients were partially exposed. Hence, external fixation of the port exposure approach was utilized to successfully retain the TIVAP through collaborative discussion. These findings provide good references for the prevention and management of postoperative port-exposure complications associated with TIVAP in patients with cancer.
Ozone attenuates chemotherapy-induced peripheral neuropathy via upregulating the AMPK-SOCS3 axis
Authors: Zhang Xiao-Tao , Zong Li-Juan , Jia Ru-Meng , Qin Xin-Miao , Ruan Shi-Rong , Lu Lin-Lin , Wang Ping , Hu Liang , Liu Wen-Tao , Yang Yang , Li Yan 
Published: August 2023

ABSTRACT

Background:
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe adverse reaction to chemotherapeutics, which seriously affects the outcome of chemotherapy and patients’ quality of life. Although it is commonly seen, it lacks effective treatment. Our previous study found that ozone could alleviate neuropathic pain. Damage-associated molecular patterns (DAMPs) or Toll-like receptor 4 (TLR4) or tissue factor (TF)-mediated neuroinflammation and microcirculation disturbance is the main reason for CIPN. Suppressors of cytokine signaling (SOCS) 3 is an endogenous negative feedback regulator of inflammation via TLR4 inhibition.

Materials and Methods:
Oxaliplatin (L-OHP) was used to establish mice’s CIPN model. Nociceptive responses were assessed by observing the ICR mice’s incidence of foot regression in mechanical indentation response experiments. Cell signaling assays were performed by Western blotting and immunohistochemistry. The mouse leukemia cells of monocyte–macrophage line RAW 264.7 were cultured to investigate the effects of ozone administration on macrophage.

Results:
Ozone decreased the expression of TF in the blood and sciatic nerve. It upregulated the adenosine 5‘-monophosphate (AMP)-activated protein kinase (AMPK)-SOCS3 axis to relieve CIPN and inhibit TF expression in vivo. SOCS3 expression was induced by ozone to inhibit the p38/TF signaling in RAW 246.7 cells. Ozone also prevented L-OHP-induced sciatic nerve demyelination. Microglia activation was inhibited, and c-Fos and calcitonin gene-related peptide (CGRP) expression was decreased in the spinal dorsal horn via ozone.

Conclusions:
In this study, we demonstrated that ozone could alleviate CIPN by upregulating the AMPK-SOCS3 axis to inhibit TF expression, which is a potential treatment for CIPN.
Awareness of sudden infant death syndrome and its associated risk factors among Saudi mothers attending well-baby clinics at PHC, PSMMC, Riyadh, Saudi Arabia: A cross-sectional study
Authors: Alanezi Saleh L. , Almusalam Yousef A. , Afify Aymen A. 
Published: August 2023

Introduction:
Sudden infant death syndrome (SIDS) is a leading cause of infant mortality all over the world. Mortality due to SIDS can be averted by educating families and caretakers about safe practices for putting infants to sleep. However, the knowledge, attitude, and practices of mothers while putting the infant to sleep is a gray areas in literature.

Aims and Objectives:
The objectives of the study were to measure the knowledge and awareness about SIDS and its associated risk factors practiced among Saudi mothers attending well-baby clinics in Saudi Arabia to develop appropriate educational program-based interventions for safe practices of infant care.

Methods:
This cross-sectional study was carried out among 385 mothers attending well-baby clinics of primary health care (PHC) and prince sultan military medical city (PSMMC) in Riyadh Saudi Arabia. Information was captured on sociodemographic characteristics, the health status of mothers and infants, knowledge, attitude, and practice followed by mothers while putting infants to sleep.

Results:
From a total number of 385 responses, 350 participants were eventually included in the final sample due to the incompletion of the questionnaire of 350 mothers; only 26% (n = 93) mothers had heard of SIDS. However, 259 mothers were willing to attend the awareness session. Only 94 mothers had knowledge as well as practicing the correct behavior of putting the infant to sleep on the back referred to as “good behavior concordant pairs.” Similarly, other good practices include not co-sharing a bed with the infant, removing pillows, blankets, and other wedged objects, using a pacifier, breastfeeding the infant during sleep, not using multiple quilts, not covering the infant’s head with a quilt, not using a head cap. The number of good behavior concordant pairs (in green) were 124, 38, 56, 98, 18, 117, and 68 respectively.

Conclusions:
The rate of knowledge and practice for good behavior regarding SIDS was low among Saudi mothers in Riyadh Saudi Arabia. SIDS-related deaths can be averted by improving the understanding of SIDS risk reduction practices among mothers by using health promotion strategies.
Assessing universal maternal health service coverage and their determinants in India: A multicentric cross-sectional study
Authors: Sharma Shantanu , Bhardwaj Aditya , Arora Kanishtha , Akhtar Faiyaz , Mehra Sunil 
Published: August 2023

Introduction:
Universal maternal health coverage (UHC) envisages access to quality healthcare services by pregnant and lactating women without any financial hardship. Our present study attempts to assess the UHC for maternal health services and their determinants, including access to quality antenatal care (ANC), quality postnatal care (PNC), and child immunization among the marginalized populations of India.

Methods:
It was a community-based cross-sectional study across five states of India among pregnant or lactating women. Quality ANC score was calculated using four indicators, including ANC registration month, attendance of four or more ANC visits, receiving at least one tetanus toxoid injection, and consumption of 100 iron-folic acid (IFA) tablets. Similarly, quality PNC care score was calculated using four indicators, including PNC within 48 h, breastfeeding initiation time, institutional delivery, and accessing conditional maternity benefit scheme. Logistic or generalized linear regression was used to depict associations depending on the outcome variables.

Results:
A total of 12,976 pregnant women’s and 18,061 lactating mothers’ data were analyzed. Illiterate women, women from below the poverty line, and rural areas had low-quality ANC and PNC scores compared with their counterparts. Marginalized women had lower odds of immunization of children and lower quality PNC scores than nonmarginalized.

Conclusions:
Sociodemographic factors, such as caste, education of women, area of residence, and economic status, are major determinants of quality ANC and PNC scores and immunization of children. Hence, interventionists ought to design community-based interventions that address the challenges in the uptake of health services.
A qualitative study on factors affecting adherence to antidiabetic medication in patients approaching a health center in an urban area
Authors: Kaur Paawanjot , Gomra Rozy , Girdhar Sangeeta , Sharma Sarit , Chaudhary Anurag 
Published: August 2023

Aim:The aim of this study was to evaluate the factors affecting adherence to antidiabetic medication among diabetic patients in India.Setting and Design:A qualitative study was conducted among 40 diabetic patients aged >30 years, on treatment for more than a year without any complications in the Urban Health Centre of Dayanand Medical College and Hospital, Ludhiana, Punjab, India.Materials and Methods:A semistructured questionnaire was harnessed to congregate data by interviewing the patients for 30–40 min in person. The interviews were recorded in the form of audios by acquiring informed consent and transcribed verbatim. The factors were then divided into barriers and enablers which were further subdivided into themes and subthemes as a result of which four major themes were built including individual, social, organizational, and community levels. These major themes were further categorized into several subthemes to assess the nonadherence to antidiabetic medications.Results:The results of the interviews depicted that the lack of knowledge, financial problems, familial issues, misconceptions regarding the disease, and side effects of taking medications daily were the major altruist for nonadherence, whereas on the other hand, positive perception about the disease, family support, and getting medications on affordable prices by some health-care institutes played an important role in enabling medication adherence as about 50% patients were adherent to the medications. Moreover, various interventions were used to escort the patients regarding medication compliance and blood glucose level monitoring such as lifestyle modifications (diet and exercise), use of reminders for medication intake on time, encouraging them to visit health-care centers, or hospitals on time for regular check-ups and by educating them regarding the long-term effects of diabetes and its prevention.
Defeating diabetes in the desert: A community-based mHealth diabetes screening intervention in Jodhpur Rajasthan
Authors: Joshi Nitin K. , Arora Vikas , Purohit Anil , Lohra Abhishek , Joshi Vibha , Shih Ting , Harsh Jagdish 
Published: August 2023

Background:
There is a paucity of demonstrated models for mHealth-based diabetes screening and coordinated care in India, especially in western Rajasthan, which is the part of Thar desert.

Materials and Methods:
JSPH collaboratively developed and implemented an easy-to-use, noninvasive, mobile phone-based screening interview, to identify adults at high risk for diabetes. The high risk for diabetes was defined using multiple clinical and epidemiologic criteria, all based on the evidence for India and globally. Since participants above 35 years or older were only considered in the screening, the application was designed to categorize the participants as high and low risk.

Results:
Out of 4000 screened participants, the percentage of males and females were 51% and 50%, respectively. Participants found to be at high risk and low risk were n = 3600 (90%) and 400 (10%). The mean age of high- and low-risk participants was 52.2 (+12.8) and 36.2 (+4.2), respectively. Of the 3600 high-risk individuals who have been given a follow-up interview, 90.50% of high-risk individuals obtained diabetes testing, and of these, 65.67% had a written report showing they test positive for diabetes or prediabetes, requiring ongoing clinical care.

Conclusions:
JSPH mHealth application provided a novel noninvasive way to better identify those at high diabetes risk in the community and demonstrated how to optimize the use of mobile health methods in diabetes prevention and care services.
Clinical and radiological efficacy of single-dose intra-articular high-molecular-weight hyaluronic acid in knee osteoarthritis
Authors: Babu Anjana , Channaveera Chethan , Gupta Ajay , Mittal Mahesh K. , Johnson Deepthi S. 
Published: August 2023

Context:
While visco-supplementation is being used for the treatment of knee osteoarthritis (OA), the published reports vary widely in benefits afforded by this treatment. It was therefore proposed to assess the objective parameters along with subjective outcomes.

Aims:
Our study assessed the radiological and clinical efficacy of single-dose high-molecular-weight intra-articular hyaluronic acid (HMW-IAHA) injection in knee OA.

Settings and Design:
This interventional cohort study was conducted in a calculated sample size of 44 patients with knee OA.

Materials and Methods:
Visual analog scale (VAS) and knee OA and outcome score (KOOS) were used for clinical assessment, and whole organ magnetic resonance imaging score (WORMS) for radiological assessment. The subjects were given a single dose of HMW-IAHA injection, 90 mg/3 ml, and were assessed on day 0 and day 90.

Statistical Analysis:
Statistical Package for Social Sciences (SPSS) software was used.

Results:
At the day 90 follow-up, there was an improvement in mean ± standard deviation values of VAS score (day 0: 8.53 ± 0.81, day 90: 5.97 ± 0.87), KOOS score (day 0: 27.33 ± 15.18, day 90: 57.26 ± 14.26), and the cartilage signal and morphology in the medial femorotibial joint (day 0: 11.02 ± 6.26 and day 90: 10.91 ± 6.22) and patellofemoral joint (day 0: 10.35 ± 4.36 and day 90: 10.28 ± 4.39) compartments. There was a decrease in synovitis score from 2.3 ± 1.61 to 1.3 ± 1.3 in the medial femorotibial joint compartment and total WORMS score (day 0: 66.57 ± 36.06, day 90: 65.14 ± 35.62).

Conclusions:
A single dose of intra-articular injection with high-molecular-weight hyaluronic acid produces improvement in the clinical symptoms and quality of life as well as is effective in maintaining the articular cartilage integrity and reducing synovial inflammation.
Impact of concomitant gastroesophageal reflux disease symptomology on prognosis and pulmonary function of chronic hypersensitivity pneumonitis
Authors: Elkhatib Wiaam Y. , Helgeson Scott A. , Baig Hassan Z. , Lee Augustine S. 
Published: August 2023

ABSTRACT

Background and Objectives:
Comorbid risk factors in chronic hypersensitivity pneumonitis (CHP) are poorly characterised. Gastroesophageal reflux disease (GERD) is linked to interstitial lung diseases like idiopathic pulmonary fibrosis (IPF), but its association and treatment in CHP is less understood. This study aims to understand the role and prevalence of GERD in CHP, plus the effect of GERD treatment on lung function and mortality.

Methods:
A tertiary referral centre panel was retrospectively reviewed for 214 patients diagnosed with CHP based on clinical history, bronchoalveolar lavage fluid analysis, imaging and histopathology. GERD diagnostic criteria included symptomology, acid suppressive therapy use and diagnostic testing. CHP patients with GERD (n = 89) and without GERD (n = 125) were compared via descriptive statistical analysis. Pulmonary function, GERD diagnosis plus treatment and other comorbidities were evaluated against CHP outcomes.

Results:
Respective differences between diagnosis and study termination dates in the GERD population versus without GERD for functional vital capacity (FVC) were − 1 L vs − 2.5 L, diffusing capacity of the lungs for carbon monoxide (DLCO) were − 2 mL/min/mmHg versus − 1 mL/min/mmHg, per cent alive at the time of study 88% versus 81%, median date of survival 574.5 versus 850 and supplemental oxygen requirement 41% versus 37%. GERD prevalence was higher in CHP patients relative to the general population. No statistical significance was found between survival curves, oxygen requirement, smoking history, FVC, or DLCO.

Conclusions:
GERD could be a harmful comorbidity in CHP though may not necessarily affect survival or functional outcomes. This aligns with previous IPF studies, though remains controversial. Further research is needed regarding this association and treatment benefit.