bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in prescribing practices for management of haemophilia: 1999–2021
Authors: Curtis Randall , Roberts Jonathan C. , Crook Nicole , Decker‐Palmer Marquita , Khainar Rahul , Baker Judith R. , Ullman Megan , Koerper Marion A. , Wu Joanne , Nichol Michael B. 
Published: March 2023

AbstractIntroductionPeople with haemophilia rely on specialists for their care, yet the specific dosing regimens of treatments prescribed by these specialists have not been widely studied.AimThe objective of this study is to describe trends in clinician prescribing practices for the management of haemophilia in the United States (US).MethodsWe administered surveys to members of the Hemostasis and Thrombosis Research Society via paper surveys at its in‐person annual symposia in 1999 and 2015, and an online survey in 2021. The surveys collected information on haemophilia treatments including factor dosing, inhibitor therapy and gene therapy.ResultsClinicians treating haemophilia for more than 50% of their practice time have increased from 37.5% of respondents in 1999 to 46.3% in 2021. Clinicians prescribing factor concentrates at >40 units/kg for routine bleeding events increased from 0% in 1999 to 29.3% in 2021 in haemophilia A (HA) and from 22.5% to 87.8% in haemophilia B (HB). In 2021, the clinicians reported prescribing emicizumab to treat HA patients (>89.5% paediatric, >85.7% adult) with or without inhibitors at least some of the time. Approximately 78.0% of respondents reported that they expected to recommend gene therapy at least some of time.ConclusionThese data indicate changing trends in prescribing practices among US haemophilia specialists during the past 22 years. Preference for high doses of factor (>40 units/kg) has increased during this period. Emicizumab prophylaxis has been prescribed for patients with and without HA inhibitors. Clinicians expect gene therapy to have value for some haemophilia patients.
Comparative complete scheme and booster effectiveness of COVID‐19 vaccines in preventing SARS‐CoV‐2 infections with SARS‐CoV‐2 Omicron (BA.1) and Delta (B.1.617.2) variants: A case–case study based on electronic health records
Authors: Kislaya Irina , Peralta‐Santos André , Borges Vítor , Vieira Luís , Sousa Carlos , Ferreira Bibiana , Pelerito Ana , Gomes João Paulo , Leite Pedro Pinto , Nunes Baltazar ,   PT COVID‐19 group
Published: March 2023

AbstractBackgroundInformation on vaccine effectiveness in a context of novel variants of concern (VOC) emergence is of key importance to inform public health policies. This study aimed to estimate a measure of comparative vaccine effectiveness between Omicron (BA.1) and Delta (B.1.617.2 and sub‐lineages) VOC according to vaccination exposure (primary or booster).MethodsWe developed a case–case study using data on RT‐PCR SARS‐CoV‐2‐positive cases notified in Portugal during Weeks 49–51, 2021. To obtain measure of comparative vaccine effectiveness, we compared the odds of vaccination in Omicron cases versus Delta using logistic regression adjusted for age group, sex, region, week of diagnosis, and laboratory of origin.ResultsHigher odds of vaccination were observed in cases infected by Omicron VOC compared with Delta VOC cases for both complete primary vaccination (odds ratio [OR] = 2.1; 95% confidence interval [CI]: 1.8 to 2.4) and booster dose (OR = 5.2; 95% CI: 3.1 to 8.8), equivalent to reduction of vaccine effectiveness from 44.7% and 92.8%, observed against infection with Delta, to −6.0% (95% CI: 29.2% to 12.7%) and 62.7% (95% CI: 35.7% to 77.9%), observed against infection with Omicron, for complete primary vaccination and booster dose, respectively.ConclusionConsistent reduction in vaccine‐induced protection against infection with Omicron was observed. Complete primary vaccination may not be protective against SARS‐CoV‐2 infection in regions where Omicron variant is dominant.
Brain reserve theory: Are adults with intellectual disability more vulnerable to age than peers with typical development?
Authors: Zemach Moran , Vakil Eli , Lifshitz Hefziba 
Published: March 2023

AbstractBackgroundLife expectancy is on rise and the intriguing question is: When does cognitive decline occur among adults with intellectual disability, compared to adults with typical development? This cross‐sectional study examined cognitive performance of crystallised/fluid intelligence, working and long‐term memory of adults with intellectual disability of etiologies other than Down syndrome (IQ 50–68) and adults with typical development (IQ 85–114) in four age cohorts (30–39; 40–49; 50–59; 60–69).MethodThe WAIS IIIHEB and the Rey‐AVLT were administered to both groups.ResultsFour patterns of cognitive performance were found: (a) Vocabulary (crystallised intelligence), Spatial Span Forward and Retention yielded similar scores across all four age cohorts in participants with typical development and with intellectual disability. (b) Similarities, Raven and Digit Span Backward exhibit lower scores only in 50–59 or 60–69 compared to the 30–39 age cohort in both groups, (c) Digit Span Forward, Spatial Span Backward and Total Leaning (LTM) yielded lower scores in the 50–59 or 60–69 age cohorts in the typical group, but similar scores in participants with intellectual disability along the age cohorts, (d) Block Design (fluid intelligence) yielded a lower score in the 50–59 cohort versus lower scores only at ages 60–69 in participants with typical development.ConclusionsOur findings suggest a possible parallel trajectory in age‐related cognitive performance for individuals with and without intellectual disability in six measures, and a possible more preserved trajectory in fluid intelligence and some memory measures in adults with intellectual disability compared to their peers. Caution should be exercised regarding Digit and Spatial Span Backwards, which yielded a floor effect in participants with intellectual disability. The Cognitive Reserve Theory, the Safeguard Hypothesis and late maturation might serve as explanations for these findings.
Professional quality of life and fear of COVID‐19 among Spanish nurses: A longitudinal repeated cross‐sectional study
Authors: González‐Nuevo Covadonga , Postigo Álvaro , González‐Menéndez Ana , Alonso‐Pérez Fernando , Cuesta Marcelino , González‐Pando David 
Published: March 2023

AbstractAim and ObjectivesTo evaluate changes in compassion fatigue (CF), burnout (BO), compassion satisfaction (CS) and fear of COVID‐19 among Spanish nurses by comparing two assessment points: before and after the COVID‐19 vaccination campaign.BackgroundThe COVID‐19 pandemic has produced a great impact in healthcare worker's professional quality of life, especially among nurses. CF, BO and fear of COVID‐19 decisively affect the care provided by nurses and put them at risk for mental health problems, so longitudinal studies are essential.DesignA repeated cross‐sectional design was carried out with a time‐lapse of 12 months.MethodsA total of 439 registered nurses in December 2020 and 410 in December 2021 participated in this study through an online survey. Data were collected using the Professional Quality of Life Questionnaire and the Fear of COVID‐19 Scale. Occupational and sociodemographic variables were also analysed. This article adheres to the STROBE guidelines for the reporting of observational studies.ResultsThe fear of COVID‐19 has not been reduced among nurses. The levels of BO remain stable and continue to be high in half of the professionals. CF has been reduced with a small effect size (d = 0.30), while CS has also decreased (d = 0.30). Positive correlations were found in both assessment points between fear of COVID‐19 and BO (r = .44, p ≤ .001; r = .41, p ≤ .001) and also between fear of COVID and CF (r = .57, p ≤ .001; r = .50, p ≤ .001). Negative correlations between fear and CS were also found (r = − .16, p = .001; r = − .22, p ≤ .001).Relevance to Clinical PracticeProgrammes to reduce fear of COVID‐19, BO and CF are needed to improve mental health and to prevent psychological distress among nurses, as well as to increase CS and preserve the productivity and quality of nursing care.Patient or Public ContributionThe nurses collaborated by participating in the present study anonymously and disinterestedly.
From Keynes' Possibilities to Contemporary Precarities: Reflections on the Origins of Our Economically and Politically Precarious Times
Authors: Ebert Norbert 
Published: March 2023

AbstractIn his essay Economic Possibilities for Our Grandchildren John Maynard Keynes delineates an economic utopia where most work is done with the aid of technology. In contrast to pessimistic views associated with the term ‘technological unemployment’ today, Keynes offers an optimistic vision for work societies where technology facilitates more freedom from paid work. Keynes also envisaged a softening of the capitalist work ethic and achievement principle. Today, however, technologically inflicted unemployment is perceived as a threat where gainful employment as a cost and meaningful activity is reduced while profits are maximized. Simultaneously, moral pressures to be employed, self‐sufficient and to contribute to society have solidified. Inspired by Keynes' vision, it is argued that the origins of our economically and politically precarious times lie in a ‘de‐politicization of work’. What Keynes perceives as economic possibilities needs to be complemented with political possibilities which otherwise turn into economic and political precarities.
Effects of anthocyanins and microbial transglutaminase on the physicochemical properties of silver carp surimi gel
Authors: Zhong Qian , Wang Yudong , Tian Yuxin , Zhuang Yang , Yang Hong 
Published: March 2023

AbstractThe objective of this study was to investigate effects of anthocyanins (AC) and microbial transglutaminase (MTGase) on the physicochemical properties of surimi gels from silver carp. The addition of AC and MTGase significantly increased gel strength and water holding capacity (WHC) of surimi gels, but the effect of MTGase was much stronger (p < .05). There were the highest gel strength, storage modulus (G′) and WHC with 0.1 g/100 g AC and 0.4 g/100 g MTGase, while they were higher than that with AC or MTGase alone. AC promoted the cross‐linking mainly by covalent and non‐covalent bonds in surimi gels, while MTGase did mainly through covalent bonds. Sodium dodecyl sulfate‐polyacrylamide gel electrophoresis (SDS‐PAGE) confirmed the results of gel strength, WHC, chemical interactions and G′ of surimi gel or paste with AC and MTGase. In general, AC and MTGase could synergistically improve the physicochemical properties of surimi gels and potentially enhance the quality of surimi‐based product from silver carp.
Concept‐based language instruction and the teaching of citation in English academic writing
Authors: Yang Ruiying Y. , Sang Yiru R. 
Published: March 2023

AbstractThis article reports a teaching project for the purpose of improving the citation ability of second language (L2) graduate students in academic writing through concept‐based language instruction (C‐BLI). “Citation” here refers to writers’ use of external sources in their own writing, which is an important and unique feature of academic writing. However, developing the ability to use citation appropriately and effectively is a difficult process for many L2 novice writers of English. This study attempts to apply C‐BLI in the teaching of citation in order to observe whether it is effective in bringing about changes in the perception and performance of novice academic writers in terms of their use of citation forms and functions. The teaching focused on citation types and functions with creatively designed SCOBAs (schema for complete orienting basis of an action) and activities. To examine the pedagogical impact of C‐BLI, we administered four measurements: questionnaire, interview, test, and revision of previously written research proposals. The four types of data were collected before and after the teaching sessions. Comparative analyses identified positive evidence that indicates the occurrence of changes in the students’ understanding of the complexity of the citation concept as well as their improved practice in the use of citations.
Optimizing graft‐recipient size matching in adolescent liver transplantation: Don't forget ex situ right posterior sectionectomy
Authors: Rossignol Guillaume , Muller Xavier , Dubois Remi , Rode Agnes , Mabrut Jean‐Yves , Mohkam Kayvan 
Published: March 2023

AbstractBackgroundGraft‐recipient size matching is a major challenge in pediatric liver transplantation, especially for adolescent recipients. Indeed, adolescents have the lowest transplantation rate among pediatric recipients, despite prioritization policies and the use of split grafts. In case of an important graft‐recipient size mismatch, ex situ graft reduction with right posterior sectionectomy (RPS) may optimize the available donor pool to benefit adolescent recipients.MethodsWe present three cases of liver graft reduction with ex situ RPS for adolescent recipients. The surgical strategy was guided by GRWR (graft/recipient weight ratio), GW/RAP (right anteroposterior distance ratio), and CT‐scan volumetric and anthropometric evaluation.ResultsRecipients were 12, 13, and 14‐year‐old and weighed 32, 47, and 35 kg, respectively. All liver grafts were procured from brain‐dead donors with a donor/recipient weight ratio >1.5. RPS was performed ex situ, removing 20% of the total liver volume leading to a decrease of the GRWR <4% and the GW/RAP <100 g/cm in each case. All three reduced grafts were successfully transplanted with a static cold storage time ranging from 390 to 510 min without the need for delayed abdominal closure. We did not observe any primary non‐function, vascular complication, or delayed graft function with a median follow‐up of 6 months. One biliary anastomotic stenosis occurred which required surgical treatment.ConclusionEx situ liver graft reduction with RPS allowed for successful transplantation in case of anthropometric graft‐recipient size mismatch in adolescent liver transplant candidates. Although the use of split grafts remains the gold standard, RPS should be acknowledged as a way to optimize the donor pool, especially for adolescent recipients.
MICA and MICB allele assortment in Finland
Authors: Koskela Satu , Tammi Silja , Clancy Jonna , Lucas Jonathan A. M. , Turner Thomas R. , Hyvärinen Kati , Ritari Jarmo , Partanen Jukka 
Published: March 2023

Genetic variation in the MICA and MICB genes located within the major histocompatibility complex region has been reported to be associated with transplantation outcome and susceptibility to autoimmune diseases and infections. Only limited data of polymorphism in these genes in different populations are available. We here report allelic variation at 2‐field resolution and the haplotypes of the MICA and MICB genes in Finland (n = 1032 individuals), a north European population with historical bottleneck and founder effects. Altogether 24 MICA and 18 MICB alleles were found, forming 70 estimated MICA‐MICB haplotypes. As compared to other populations frequency differences were found, for example, MICA*010:01 was found to be at an allele frequency of 0.133 in Finland which is higher than in other European populations (0.021–0.077), but close to Asian populations (0.151–0.220). Three novel alleles with amino acid change are described. The results demonstrate a relatively high level of polymorphism and population differences in MICA and MICB allele distribution.
Investigating the dynamics of protein–protein interactions in plants
Authors: Zhang Youjun , Chen Moxian , Liu Tieyuan , Qin Kezhen , Fernie Alisdair R. 
Published: March 2023

SUMMARYBoth stable and transient protein interactions play an important role in the complex assemblies required for the proper functioning of living cells. Several methods have been developed to monitor protein–protein interactions in plants. However, the detection of dynamic protein complexes is very challenging, with few technologies available for this purpose. Here, we developed a new platform using the plant UBIQUITIN promoter to drive transgene expression and thereby to detect protein interactions in planta. Typically, to decide which side of the protein to link the tags, the subcellular localization of the protein fused either N‐terminal or C‐terminal mCitrine was firstly confirmed by using eight different specific mCherry markers. Following stable or transient protein expression in plants, the protein interaction network was detected by affinity purification mass spectrometry. These interactions were subsequently confirmed by bimolecular fluorescence complementation (BiFC), bioluminescence resonance energy transfer and co‐immunoprecipitation assays. The dynamics of these interactions were monitored by Förster resonance energy transfer (FRET) and split‐nano luciferase, whilst the ternary protein complex association was monitored by BiFC‐FRET. Using the canonical glycolytic metabolon as an example, the interaction between these enzymes was characterized under conditions that mimic physiologically relevant energy statuses.
Isoperimetric problems for zonotopes
Authors: Joós Antal , Lángi Zsolt 
Published: March 2023

AbstractShephard (Canad. J. Math. 26 (1974), 302–321) proved a decomposition theorem for zonotopes yielding a simple formula for their volume. In this note, we prove a generalization of this theorem yielding similar formulae for their intrinsic volumes. We use this result to investigate geometric extremum problems for zonotopes generated by a given number of segments. In particular, we solve isoperimetric problems for d‐dimensional zonotopes generated by d or segments, and give asymptotic estimates for the solutions of similar problems for zonotopes generated by sufficiently many segments. In addition, we present applications of our results to the ℓ1 polarization problem on the unit sphere and to a vector‐valued Maclaurin inequality conjectured by Brazitikos and McIntyre in 2021.
A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis
Authors: Tsai Cheng-Yu , Saito Toshie , Sarangdhar Mayur , Abu-El-Haija Maisam , Wen Li , Lee Bomi , Yu Mang , Lipata Den A. , Manohar Murli , Barakat Monique T. , Contrepois Kévin , Tran Thai Hoa , Theoret Yves , Bo Na , Ding Ying , Stevenson Kristen , Ladas Elena J. , Silverman Lewis B. , Quadro Loredana , Anthony Tracy G. , Jegga Anil G. , Husain Sohail Z. 
Published: March 2023

Among drug-induced adverse events, pancreatitis is life-threatening and results in substantial morbidity. A prototype example is the pancreatitis caused by asparaginase, a crucial drug used to treat acute lymphoblastic leukemia (ALL). Here, we used a systems approach to identify the factors affecting asparaginase-associated pancreatitis (AAP). Connectivity Map analysis of the transcriptomic data showed that asparaginase-induced gene signatures were potentially reversed by retinoids (vitamin A and its analogs). Analysis of a large electronic health record database (TriNetX) and the U.S. Federal Drug Administration Adverse Events Reporting System demonstrated a reduction in AAP risk with concomitant exposure to vitamin A. Furthermore, we performed a global metabolomic screening of plasma samples from 24 individuals with ALL who developed pancreatitis (cases) and 26 individuals with ALL who did not develop pancreatitis (controls), before and after a single exposure to asparaginase. Screening from this discovery cohort revealed that plasma carotenoids were lower in the cases than in controls. This finding was validated in a larger external cohort. A 30-day dietary recall showed that the cases received less dietary vitamin A than the controls did. In mice, asparaginase administration alone was sufficient to reduce circulating and hepatic retinol. Based on these data, we propose that circulating retinoids protect against pancreatic inflammation and that asparaginase reduces circulating retinoids. Moreover, we show that AAP is more likely to develop with reduced dietary vitamin A intake. The systems approach taken for AAP provides an impetus to examine the role of dietary vitamin A supplementation in preventing or treating AAP.
The early opening of the Equatorial Atlantic gateway and the evolution of Cretaceous peak warming
Authors: Dummann Wolf , Hofmann Peter , Herrle Jens O. , Frank Martin , Wagner Thomas 
Published: March 2023

Abstract
The Cretaceous opening of the Equatorial Atlantic gateway (EAG) is considered a driver of major changes in global oceanography, carbon cycling, and climate. However, the early stages of EAG opening are poorly understood. We present seawater Nd-isotope, bulk geochemical, and micropaleontological data from two South Atlantic drill cores that constrain the onset of shallow (&lt;500 m) and intermediate (&lt;~1000 m) water mass exchange across the EAG to 113 Ma and 107 Ma, respectively. Deep water mass exchange (&gt;2000 m) was enabled by at least ca. 100 Ma, as much as 10 m.y. earlier than previously estimated. In response to EAG opening, deep-water ventilation in the South Atlantic, North Atlantic, and Tethys basins intensified, thereby triggering basin-scale reductions in organic carbon burial. We propose that the consequent drop in carbon sequestration in concert with increased atmospheric CO2 fluxes from subduction zones acted as major amplifiers of global warming that culminated in peak greenhouse conditions during the mid-Cretaceous.
Lung Cancer App (LuCApp) study protocol: a randomised controlled trial to evaluate a mobile supportive care app for patients with metastatic lung cancer
Authors: Ciani Oriana , Cucciniello Maria , Petracca Francesco , Apolone Giovanni , Merlini Giampaolo , Novello Silvia , Pedrazzoli Paolo , Zilembo Nicoletta , Broglia Chiara , Capelletto Enrica , Garassino Marina , Nicod Elena , Tarricone Rosanna 
Published: March 2023

IntroductionMobile health technologies may enhance patient empowerment and data integration along the whole care continuum. However, these interventions pose relatively new regulatory, organisational and technological challenges that limit appropriate evaluation. Lung Cancer App (LuCApp) is a mobile application developed by researchers and clinicians to promote real-time monitoring and management of patients’ symptoms. This protocol illustrates a clinical trial designed to evaluate the usability, effectiveness and cost-effectiveness of LuCApp versus standard of care.Methods and analysisThis is a 24-week two-arm non-blinded multicentre parallel randomised controlled trial. A total of 120 adult patients diagnosed with small or non-small cell lung cancer and eligible for pharmaceutical treatments will be allocated 1:1 to receiving either standard care or LuCApp in addition to standard care at three oncology sites in Northern Italy. During the treatment period, LuCApp allows daily monitoring and grading of a list of symptoms, which trigger alerts to the physicians in case predefined severity thresholds are met. Patients will complete a baseline assessment and a set of valid and reliable patient-reported outcome measures every 3±1 weeks, and up to 24 weeks. The primary outcome is the change in the score of the Trial Outcome Index in the Functional Assessment of Cancer Therapy (Lung) questionnaire from baseline to 12 weeks. Secondary outcomes are the Lung Cancer Subscale, the EuroQoL 5D-5L questionnaire, the Hospital Anxiety and Depression Scale, the Supportive Care Needs Survey Short Form, the app usability questionnaire and the Zarit Burden Interview for the main caregiver.Ethics and disseminationThe trial received ethical approval from the three clinical sites. Trial results will be disseminated through peer-reviewed publications and conference presentations.ConclusionsThis trial makes a timely contribution to test a mobile application designed to improve the quality of life and delivery of care for patients with lung cancer.Trial registration numberNCT03512015; Pre-results.