bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic vidian and vidian‐branch neurectomy for refractory allergic rhinitis: A systematic review
Authors: Niu Xun , Chen Yuzhang , Zhou Tao , Xiao Hongjun 
Published: September 2023

AbstractBackgroundEndoscopic vidian neurectomy is expected to provide good therapeutic relief in patients with allergic rhinitis (AR) being refractory to medication therapy or conservative surgery. However, the evidence bases for its benefit remain debatable. In this study, we conducted a systematic review and meta‐analysis to clarify the therapeutic role of various forms of vidian neurectomy in refractory AR.MethodPreferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines were used to conduct a systematic review of primary studies that reported original patient data for endoscopic vidian neurectomy (EVN) and vidian‐branch neurectomy, which includes selective vidian neurectomy (SVN) and posterior nasal neurectomy (PNN). The primary outcome was patient‐reported outcome measures (PROMs), including the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) and Visual Analog Scale (VAS), to assess an improvement in nasal symptom severity and quality of patient's life. The incidence of surgical complications and other objective outcomes were considered secondary outcomes.ResultsThis review included 24 clinical studies involving 1677 patients with refractory AR, of which 510 patients in six studies had combined chronic rhinosinusitis with nasal polyps (CRSwNP) and 95 patients in one study had combined asthma. Postoperative PROMs were significantly better than preoperatively in almost all patients who underwent vidianp (RQLQ: standardized mean difference [SMD] = 2.66, 95% confidence interval [CI] = 2.40–2.92, p < 0.001; VAS: SMD = 5.15, 95% CI = 4.29–6.02, p < 0.001) or vidian‐branch neurectomy (RQLQ in PNN: SMD = 3.29, 95% CI = 2.45–4.13, p < 0.001; VAS in PNN: SMD = 4.38, 95% CI = 3.41–5.34, p < 0.001), and were generally better than in the conservative treatment group. Dividing with 18 months as the cutoff point, a subgroup analysis of the follow‐up period was conducted, and the results showed that both long‐term and short‐term postoperative patients had considerably reduced symptoms compared to the preoperative period. The two surgical procedures, SVN and PNN, attributed to vidian‐branch neurectomy have extremely few complications. However, EVN is more likely to cause dry eyes and palatal numbness, with no other serious complications. In patients with AR and CRSwNP, vidian or selective vidian neurectomy combined with functional endoscopic sinus surgery (FESS) is more effective than conventional FESS (RQLQ: SMD = 2.17, 95% CI = 1.66–2.69, p < 0.001; VAS: SMD = 6.42, 95% CI = 4.78–8.06, p < 0.001). For patients who have both AR and asthma, SVN with pharyngeal branch excision is a potential treatment option.ConclusionEVN and vidian‐branch neurectomy (including SVN and PNN) are effective treatments, but the former has a higher risk of complications. Additionally, vidian‐branch neurectomy with FESS is beneficial for patients with mixed CRSwNP. SVN is a potential approach for patients with coexisting AR and asthma.
An Organic Coordination Manganese Complex as Cathode for High‐Voltage Aqueous Zinc‐metal Battery
Authors: Zhang Feifan , Wang Gege , Wu Jing , Chi Xiaowei , Liu Yu 
Published: September 2023

AbstractAqueous Zn−Mn battery has been considered as the most promising scalable energy‐storage system due to its intrinsic safety and especially ultralow cost. However, the traditional Zn−Mn battery mainly using manganese oxides as cathode shows low voltage and suffers from dissolution/disproportionation of the cathode during cycling. Herein, for the first time, a high‐voltage and long‐cycle Zn−Mn battery based on a highly reversible organic coordination manganese complex cathode (Manganese polyacrylate, PAL−Mn) was constructed. Benefiting from the insoluble carboxylate ligand of PAL−Mn that can suppress shuttle effect and disproportionationation reaction of Mn3+ in a mild electrolyte, Mn3+/Mn2+ reaction in coordination state is realized, which not only offers a high discharge voltage of 1.67 V but also exhibits excellent cyclability (100 % capacity retention, after 4000 cycles). High voltage reaction endows the Zn−Mn battery high specific energy (600 Wh kg−1 at 0.2 A g−1), indicating a bright application prospect. The strategy of introducing carboxylate ligands in Zn−Mn battery to harness high‐voltage reaction of Mn3+/Mn2+ well broadens the research of high‐voltage Zn−Mn batteries under mild electrolyte conditions.
StereoPHIP: Stereoselective Parahydrogen‐Induced Polarization
Authors: Huynh Mai T. , Buchanan Emily , Chirayil Sara , Adebesin Adeniyi M. , Kovacs Zoltan 
Published: September 2023

AbstractParahydrogen‐induced polarization (PHIP) followed by polarization transfer to 13C is a rapidly developing technique for the generation of 13C‐hyperpolarized substrates. Chirality plays an essential role in living systems and differential metabolism of enantiomeric pairs of metabolic substrates is well documented. Inspired by asymmetric hydrogenation, here we report stereoPHIP, which involves the addition of parahydrogen to a prochiral substrate with a chiral catalyst followed by polarization transfer to 13C spins. We demonstrate that parahydrogen could be rapidly added to the prochiral precursor to both enantiomers of lactic acid (D and L), with both the (R,R) and (S,S) enantiomers of a chiral rhodium(I) catalyst to afford highly 13C‐hyperpolarized (over 20 %) L‐ and D‐lactate ester derivatives, respectively, with excellent stereoselectivity. We also show that the hyperpolarized 1H signal decays obtained with the (R,R) and (S,S) catalysts were markedly different. StereoPHIP expands the scope of conventional PHIP to the production of 13C hyperpolarized chiral substrates with high stereoselectivity.
Combining Virtual Reality with Mixed Reality for Efficient Training in Battery Manufacturing
Authors: Denisart Lucie , Zapata‐Dominguez Diana , David Xavier , Leclere Aubin , Lelong Romain , Liu Chaoyue , Xu Jiahui , Loup‐Escande Emilie , Franco Alejandro A. 
Published: September 2023

AbstractThe manufacturing process of batteries can be complex and time‐consuming. We introduce a new version of the digital twin of our lithium‐ion battery pilot line, Simubat 4.0 Gen‐2, based on a new combination of Virtual Reality and Mixed Reality. This digital twin is designed to deliver training on the lithium‐ion battery manufacturing process and electrode properties. This tool aims to make users active learners, helping them visualize and understand complex concepts and meets a strong need for skilled labor linked to the blooming of battery gigafactory, in particular in our region. We report here a detailed study of the educational contribution of Simubat 4.0 Gen‐2. This study was performed during two filmed training sessions: the first one with chemistry MSc. students, and the second one with AESC Gigafactory trainees. We used questionnaires to measure the usability and usefulness and at the same time, we studied the usage by analyzing errors and qualitatively assessing communications among the participants. Our study revealed that users had more knowledge after using our digital twin; the tool was evaluated as being efficient by the users and it has been proven to be suitable for training in battery manufacturing.
Revealing the Formation of Dialkyl Dioxahexane Dioate Products from Ethylene Carbonate based Electrolytes on Lithium and Potassium Surfaces
Authors: Hofmann Andreas , Müller Freya , Schöner Sandro , Jeschull Fabian 
Published: September 2023

AbstractIn this study, the formation of dicarbonate degradation products of ethylene carbonate‐based carbonate mixtures containing dimethyl carbonate, ethyl methyl carbonate or diethyl carbonate that were combined with lithium or potassium metal, is investigated. It is shown by NMR and GCMS that the dicarbonate products dimethyl dioxahexane dioate, ethyl methyl dioxahexane dioate and diethyl dioxahexane dioate are formed from the reactants to different extents and, in particular, the potassium surface initiates the fast formation of the corresponding dicarbonate products. Experiments with deuterated DMC suggest an intermolecular mechanism of the dicarbonate formation. In cell tests, namely potassium vs. graphite, it is shown that the electrolyte formulation with the lowest tendency to dicarbonate formation (EC/DEC) exhibited the best cell stability respectively lowest cell aging.
Teachers’ responses to ethnic discrimination: An exploratory study in Flemish secondary schools
Authors: Hagenaars Marloes , Lafrarchi Naïma , Vantieghem Wendelien , Stevens Peter A. J. 
Published: September 2023

AbstractWhile most research has focussed on the experiences and consequences of ethnic discrimination for students, little is known about how teachers respond to ethnic discrimination. Teachers’ responses are important as they may affect the outcomes of ethnic discrimination for students. Additionally, many studies have shown that teachers find it difficult to respond or talk about these issues but we know very little about how they act or address these challenges. Using a qualitative sample of 48 teachers, 23 students and four headteachers, this study explores (1) how secondary school teachers respond to ethnic discrimination and (2) what might explain variability in their responses. We found that teachers vary in their responses to incidents of ethnic discrimination between students (or incidents in which the teacher was a third party) in comparison with accusations of ethnic discrimination (or incidents in which the teacher was a main protagonist). When teachers responded to incidents of ethnic discrimination, they generally treat it as a learning opportunity and expect students to be ‘calm’, ‘open‐minded’, ‘reflective’, ‘respectful’ and ‘communicative’. However, when teachers become the centre of the debate and are accused of discriminatory behaviour, they do not apply these criteria but deny or downplay the allegations. Differences in teachers’ responses were related to background characteristics (years of teaching experience, school context, ethnic background, subject of teaching), role perceptions, basic needs for teaching, perceptions of students and a fear of being perceived as a racist.
The neural bases of sport fan reactions to teams: Evidence from a neuroimaging study
Authors: Cayolla Ricardo , Biscaia Rui , Baumeister Roy F. , Fetscherin Marc , Brito‐Costa Sónia , Duarte Isabel C. , Castelo‐Branco Miguel 
Published: September 2023

AbstractThis study uses neuroimaging methods to identify patterns of brain activation among sport fans in reaction to team stimuli. In a whole‐brain analysis without selected regions in advance, the purposes were to identify the structures involved when fans are exposed to positive, neutral, and negative events and to learn what events activate more limbic networks. A total of 53 individuals participated in and functional magnetic resonance imaging experiment involving the presentation of videos in various situations. Findings indicate the activation of the cingulate gyrus and other structures of the limbic system, as the hippocampus and parahippocampus. We also found involvement of the ventral tegmental area of the reward system. Additionally, brain activity in emotional regulation and memory areas were more influenced by positive than neutral and negative videos. It was also found the involvement of other areas not directly included in the limbic or reward systems. This study provides the neural basis of fan reactions to team‐related stimuli. Sport clubs should be aware that negative content seems to be suppressed from emotional memory and positive videos trigger more emotion and memory areas than neutral and negative videos.
Mikania micranthaKunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential
Authors: Ali Khan Muahmmad , El‐Kersh Dina M. , Islam Md. Shafiqul , Ara Khan Shams , Kamli Hossam , Sarkar Chandan , Bhuia Md. Shimul , Islam Tawhida , Chandra Shill Manik , Gobe Glenda C. , Sönmez Gürer Eda , Setzer William N. , Sharifi‐Rad Javad , Torequl Islam Muhammad 
Published: September 2023

AbstractMikania micranthais utilized as a therapeutic for the treatment of various human ailments including insect bites, rashes and itches of skin, chicken pox, healing of sores and wounds, colds and fever, nausea, jaundice, rheumatism, and respiratory ailments. This study aimed at summarizing the traditional uses, phytochemical profile, and biological activities ofM. micranthabased on obtainable information screened from different databases. An up‐to‐date search was performed onM. micranthain PubMed, Science Direct, clinicaltrials.gov, and Google Scholar databases with specific keywords. No language restrictions were imposed. Published articles, theses, seminar/conference papers, abstracts, and books on ethnobotany, phytochemistry and pharmacological evidence were considered. Based on the inclusion criteria, this study includes 53 published records from the above‐mentioned databases. The results suggest that fresh leaves and whole plant are frequently used in folk medicine. The plant contains more than 150 different phytochemicals under the following groups: essential oils, phenolics and flavonoids, terpenes, terpene lactones, glycosides, and sulfated flavonoids. It contains carbohydrates and micronutrients including vitamins and major and trace minerals.M. micranthapossesses antioxidant, anti‐inflammatory, anti‐microbial, anti‐dermatophytic, anti‐protozoal, anthelmintic, cytotoxic, anxiolytic, anti‐diabetic, lipid‐lowering and antidiabetic, spasmolytic, memory‐enhancing, wound‐healing, anti‐aging, and thrombolytic activities. No clinical studies have been reported to date.M. micranthamight be one of the potential sources of phytotherapeutic compounds against diverse ailments in humans. Studies are required to confirm its safety profile in experimental animals prior to initiating clinical trials. Moreover, adequate investigation is also crucial to clarify exact mechanism of action for each biological effect.
METTL3‐mediated N6‐methyladenosine exacerbates ferroptosis via m6A‐IGF2BP2‐dependent mitochondrial metabolic reprogramming in sepsis‐induced acute lung injury
Authors: Zhang Hao , Wu Dan , Wang Yanghanzhao , Guo Kefang , Spencer Charles B. , Ortoga Lilibeth , Qu Mengdi , Shi Yuxin , Shao Yuwen , Wang Zhiping , Cata Juan P. , Miao Changhong 
Published: September 2023

AbstractNeutrophil extracellular traps (NETs), released by polymorphonuclear neutrophils (PMNs), exert a robust antimicrobial function in infectious diseases such as sepsis. NETs also contribute to the pathogenesis and exacerbation of sepsis. Although the lung is highly vulnerable to infections, few studies have explored the role of NETs in sepsis‐induced acute lung injury (SI‐ALI). We demonstrate that NETs induce SI‐ALI via enhanced ferroptosis in alveolar epithelial cells. Our findings reveal that the excessive release of NETs in patients and mice with SI‐ALI is accompanied by upregulation of ferroptosis depending on METTL3‐induced m6A modification of hypoxia‐inducible factor‐1α (HIF‐1α) and subsequent mitochondrial metabolic reprogramming. In addition to conducting METTL3 overexpression and knockdown experiments in vitro, we also investigated the impact of ferroptosis on SI‐ALI caused by NETs in a caecum ligation and puncture (CLP)‐induced SI‐ALI model using METTL3 condition knockout (CKO) mice and wild‐type mice. Our results indicate the crucial role of NETs in the progression of SI‐ALI via NET‐activated METTL3 m6A‐IGF2BP2‐dependent m6A modification of HIF‐1α, which further contributes to metabolic reprogramming and ferroptosis in alveolar epithelial cells.
Tackling local ecological homogeneity: Finding intraspecific trait variability in local populations of Mediterranean plants
Authors: Iozia Lorenzo Maria , Varone Laura 
Published: September 2023

AbstractLocal homogeneity, in ecology, is the often undisclosed assumption that variability within populations is negligible or mostly distributed evenly. In large areas, this can lead to the aggregation of different populations without regard for their unique needs and characteristics, such as drought sensitivity and functional trait distributions. Here, we discuss whether this assumption can be justified, and we hypothesize that discerning the source of variation between plasticity and adaptation could be a feasible approach to formulate an informed decision. We test this hypothesis on plants, resorting to a common garden experiment to determine the source of variation of several plant functional traits at a local scale (~60 km) of three wild species: Quercus ilex, Pistacia lentiscus, and Cistus salviifolius. Individuals of each species were sourced from three key sites chosen along a local aridity gradient. Our approach led to the rejection of the local homogeneity assumption for Q. ilex and C. salviifolius at this scale due to the adaptive divergence observed among neighboring populations. This case study provides evidence that addressing local homogeneity can highlight diverging populations in a relatively simple way. We conclude that gathering empirical evidence on intraspecific variability is a feasible approach that can provide researchers with solid bases to decide whether to adopt the local homogeneity assumption or not.
Catabolism of fats and branched‐chain amino acids in children with Type 1 diabetes: Association with glycaemic control and total daily insulin dose
Authors: Hendrix Grace , Lokhnygina Yuliya , Ramaker Megan , Ilkayeva Olga , Muehlbauer Michael , Evans William , Rasbach Lisa , Benjamin Robert , Freemark Michael , Gumus Balikcioglu Pinar 
Published: September 2023

AbstractObjectiveHyperglycaemia in Type 1 diabetes (T1D) results from an absolute insulin deficiency. However, insulin resistance (IR) may exacerbate glycaemic instability in T1D and contribute to long‐term cardiovascular complications. We previously showed that IR in teenagers with obesity is associated with sex‐dependent derangements in the catabolism of branched‐chain amino acids (BCAA) and fatty acids. Here we hypothesized that byproducts of BCAA and fatty acid metabolism may serve as biomarkers or determinants of glycaemic control and IR in prepubertal or early pubertal children with T1D.MethodsMetabolites, hormones and cytokines from fasting blood samples were analysed in 28 children (15 females, 13 males; age 6–11 years) with T1D. Principal components analysis (PCA) and multiple linear regression models were used to correlate metabolites of interest with glycaemic control, total daily insulin dose (TDD, units/kg/d), adiponectin and the triglyceride (TG) to high‐density lipoprotein (HDL) ratio.ResultsMales and females were comparable in age, BMI‐z, insulin sensitivity, glycaemic control, inflammatory markers, BCAAs and C2/C3/C5‐acylcarnitines. The majority of components retained in PCA were related to fatty acid oxidation (FAO) and BCAA catabolism. HbA1c correlated positively with Factor 2 (acylcarnitines, incomplete FAO) and Factor 9 (fasting glucose). TDD correlated negatively with C3 and C5 and Factor 10 (BCAA catabolism) and positively with the ratio of C2 to C3 + C5 and Factor 9 (fasting glucose).ConclusionsThese findings suggest that glucose intolerance in prepubertal or early pubertal children with T1D is accompanied by incomplete FAO while TDD is associated with preferential catabolism of fats relative to amino acids.
Cyclic response of infilled RC frames with window and door openings: Experimental results and damage interpretation
Authors: Di Trapani Fabio , Khan Nisar Ali , Zhou Lin , Demartino Cristoforo , Monti Giorgio 
Published: September 2023

AbstractThe paper presents the results of an experimental investigation assessing the influence of the openings typology and position on the cyclic response of masonry‐infilled reinforced concrete frames. The experimental program consisted of seven 2/3 scale square frame specimens infilled with hollow clay bricks, which were subjected to quasi‐static lateral cyclic tests up to large drifts. A reference bare frame was also tested for comparison. The specimens included solid infill walls, infills with door openings, and infills with window central and eccentric openings. The experimental responses of the specimens were analyzed in terms of strength, stiffness, energy dissipation capacity, and equivalent damping, and were compared to those of the reference bare frame and fully infilled frame. Results revealed a significant modification of the resisting mechanisms as a function of the typology and position of the openings with respect to the case of a fully infilled frame, although the lateral resisting capacity was not substantially modified. On the other hand, it was observed that the achievement of the limit state thresholds occurred at substantially different interstorey drifts, indicating different damage metrics. Simple regression analyses, based on the experimental results of this study and from the literature, were finally conducted to interpret the modification of the peak force and of the corresponding drift as a function of synthetic parameters defining the opening arrangement.
An experimental investigation of porosity gradient and staggered arrangements in packed bed thermal energy storage
Authors: Asif Muhammad , Rabbi Jawad , Bibi Wajeeha 
Published: September 2023

AbstractOwing to the intermittent nature of solar energy, the thermal energy from the sun or waste heat can be stored in the form of latent heat in a packed bed of phase change material (PCM). In this article, PCM‐based latent heat thermal energy storage is experimentally investigated, and the effects of porosity and specific surface area (ratio of surface area to the volume of the encapsulation) on the charging and discharging times are evaluated in packed bed thermal energy storage. Locally available paraffin wax was utilized as PCM. Differential scanning calorimetry (DSC) was used to investigate the thermal properties of paraffin wax. Enthalpy of phase change, melting point, and specific heat capacity of the paraffin wax were obtained by using DSC. Experimental results revealed that there was a 17% decrease in the charging time when porosity was reduced from 0.568 to 0.485, and the corresponding surface area was 2.581 and 3.4546 m2/m3, respectively.
Synthesis of queuine by colonic gut microbiome via cross‐feeding
Authors: Yan Fujie , Xiang Shasha , Shi Lihua , Zhu Xuan 
Published: September 2023

AbstractQueuine (Que) is an essential micronutrient, and its deficiency will lead to errors in tRNA modification and protein misfold, further to diseases. Meanwhile, the content of Que in food will be further reduced due to the modern planting pattern and processing. In this study, an idea, synthetic biology of gut microbiome, was introduced to meet people's demand for Que. Further, various food can be used as a media for promoting the growth of synthetic biology of flora and the concentrations of Que. Through this research, gut bacteria (Escherichia coli K12, Bacteroides fragilis ATCC25285, and Lactobacillus reuteri DSM20058) with abilities of Que independent synthesis in vitro were selected, and higher productivity of Que was fulfilled through the above three strains cocultivation via cross‐feeding. Moreover, the effect of Que on the structure of microbiome was also studied, in order to figure out the continuous synthesis of Que by this coculture system in colonic situation. Que could enhance bacterial α‐diversity, increase the abundance of Limosilactobacillus, Pediococcus, and Lactobacillus, while decrease the abundance of Eschi‐Shigella. Three bacteria combination intervention changed intestinal microbial composition, and distribution of enzymes transglycozyme, QueA, and QueG that involved in last three steps of Que synthesis in microorganisms was significantly changed. These results provide an experimental basis for colonic synthesis of Que via food intervention to solve the deficiency Que in human body. Here, we regard gut microbes as a fermentation system in human body, providing a constant supply of tiny but important substance that humans need.