bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use and Effects of Telemedicine on Complementary, Alternative, and Integrative Medicine Practices: A Scoping Review
Authors: Noronha Noella , Shah Aimun Qadeer , Chin-See Robert , Hanna Christina , Kadri Zeest , Marwaha Amn , Rambharack Neetu , Ng Jeremy Y 
Published: January 2023

Abstract
Background: Telemedicine includes the delivery of health-care services and sharing of health information across distances. Past research has found that telemedicine can play a role in enhancing complementary, alternative, and integrative medicine (CAIM) while allowing the maintenance of cultural values and ancestral knowledge. This scoping review synthesized evidence regarding the use of telemedicine in the context of CAIM.
Methods: Following Arksey and O’Malley’s scoping review framework, CINAHL, PsycINFO, MEDLINE, EMBASE and AMED databases were searched systematically. The CADTH website was also searched for grey literature. Eligible articles included a CAIM practice or therapy offered through telemedicine, with no restrictions placed on the type of telemedicine technology used. Inductive thematic analysis was conducted to synthesise common themes among the included studies.
Results: Sixty-two articles were included in this synthesis. The following themes emerged: 1) the practitioner view of CAIM delivered through telemedicine, 2) the patient view of CAIM delivered through telemedicine, and 3) the technological impacts of telemedicine delivery of CAIM.
Conclusions: Studies have shown that telemedicine delivery of CAIM is feasible, acceptable, and results in positive health outcomes. Some barriers remain such as existing illness and morbidity, inability to form strong patient-provider relationships relative to face-to-face approaches, and technological difficulties. Future intervention research should focus on reducing such barriers, as well as explore which patient population would realize the greatest benefit from CAIM delivered via telemedicine, and the impact of interventions on providers and caregivers.
The Influence of Financial Development on Wealth Inequality in Capitalism: Fresh Evidence from Emerging Countries
Authors: Cengiz Orhan , Manga Müge 
Published: January 2023

Abstract

Our paper investigates the impact of financial development on wealth inequality for the ten emerging countries, Brazil, China, India, Indonesia, Malaysia, Mexico, Philippines, South Africa, Thailand, and Turkey, from 1995 to 2020 by observing the effect of economic growth and trade openness. By applying the augmented mean group (AMG) estimator, the empirical findings reveal that financial development causes increasing wealth inequality for panel groups. Also, this increasing effect has been observed in Brazil, China, Mexico, and the Philippines. Moreover, economic growth and trade openness positively impact wealth inequality for panel samples. Dumitrescu and Hurlin’s (2012) causality test results indicate a two-way causality relationship among financial development and wealth inequality, economic growth and wealth inequality, wealth inequality and trade openness. Our paper highlights the major policy implementation that the government intervention plays a vital role in facilitating equal access to financial assets for lower-income people.
Finite-time adaptive control for microgravity vibration isolation system with full-state constraints
Authors: Ma Guangcheng , Wang Aixue , Wang Shuquan , Xia Hongwei , Zhang Long , Liu Wei 
Published: January 2023

Abstract
This article proposes a finite-time adaptive control strategy for a class of vibration isolation systems with external disturbances and full-state constraints. Time-varying barrier Lyapunov functions (TBLFs) are designed to achieve suppression performance under limited rattle space. Adaptive laws are applied to deal with parameters uncertainty which is caused by various mass and momentum. By regarding internal coupling terms and external disturbances as lumped disturbances, a predefined-time observer is employed to handle them. Furthermore, command filters are used to remove the burdens of the computational explosion. With the aid of auxiliary system, command filters errors are eliminated. And the actuator saturation is addressed by auxiliary system as well. By using the finite-time Lyapunov stability theory, it proves that all the states converge in finite time. Finally, simulations are given to verify the effectiveness and benefits of the developed control strategy with a trade-off between the improved suppression performance, limited mechanical constraints and robustness.
Dynamic Characteristic of Rudder Loop with Rough Revolute Joint Clearance
Authors: Guo Jianan , Wang Yingzan , Zhang Xingwei , Cao Sheng , Liu Zhansheng 
Published: January 2023

Abstract
The joint clearance of rudder loop has a significant impact in achieving the high-precision attitude control of aircraft. This study proposed a novel revolute joint clearance contact model considering surface topography. Such a model identified that the impact dynamic characteristics were significantly influenced by parameters such as contact speed, roughness, and curvature radius of asperities. The dynamic model of the rudder loop was based on the Lagrange equation and the contact model of revolute joint clearance. Results indicated that rudder angle error, contact force, and impact frequency non-linearly increased along with the increase of motor speed. The increment of joint clearance caused increased rudder angle error and contact force, but a decreased impact frequency. An increase in contact surface roughness decreased the contact force and exerted insignificant effects on rudder angle and impact frequency. To verify the dynamic model, a dynamic characteristic test rig of rudder loop was established. This study can improve the dynamic analysis accuracy of the rudder loop with clearance and provide a solid theoretical basis for solving the high-precision control of the discontinuous structure.
How the Regulatory Authority Effects Development of Meso Level Competitiveness of Industry: A Research on Istanbul Finance Sector
Authors: Kasımoglu Murat , Altın Ayaz Yusuf , Akyürek Server Sevil , ölçen olcay 
Published: January 2023

Abstract
Nowadays, the financial services sector cluster is the sector in which global players are most connected to each other globally. In order to create a highly competitive sector, a solid infrastructure should be completed and a stable institutionalized financial system should be ensured. The aim is to evaluate the relations between the factors affecting the international competitiveness of the finance sector in Istanbul, based on M. Porter's Diamond Model, with a holistic approach. As the results of SEM Analysis on Istanbul, it has been determined that government practices has got indirect impacts on companies’ strategy and competition as a leading factor and also on transportation, although government applications have direct positive effect on legal regulatory infrastructure; market demand conditions, information-technology-based infrastructure, education and HR, workplace-environment, supportive players, and companies' strategic competition policies. These results highlight the importance of institutionalization of financial sectors and supportive laws.
JEL Codes: G15, G20
Hydrology and hydrological extremes under climate change scenarios in the Bosque watershed, North-Central, Texas, USA
Authors: Tefera Gebrekidan Worku , Ray Ram Lakhan 
Published: January 2023

Abstract
This study evaluates hydrology and hydrological extremes under future climate change scenarios. The climate change scenarios were developed from multiple Global Circulation Models (GCMs), Representative Concentration Pathway (RCPs) scenarios, and statistical downscaling techniques. The hydrological model, Soil Water Assessment Tool (SWAT), was calibrated and validated using the Differential Split-Sample (DSS), where the observed period was divided into relatively 'dry' and 'wet' periods based on observed streamflow. This was to ensure hydrological model robustness simulating contrasting climate conditions. The model was also calibrated and validated at the multi-gauges of the watershed. The multi-model ensemble and single-climate model simulations were used to quantify changes in hydrology and hydrological extremes under future climate scenarios. Future climate change scenarios revealed a reduction in precipitation (in the order of -9.1% to 4.9%) and a consistent increase in maximum temperature (0.34℃ to 4.10℃) and minimum temperature (-0.15 ℃ to 3.7℃) in different climate model simulations. The climate change scenarios triggered a reduction of surface runoff and streamflow and a moderateincrease in evapotranspiration. A decrease in high flow (Q5) and low flow (Q95) was projected from future climate change scenarios. A higher reduction of low flow and annual minimum flow is also simulated in future climate scenarios. Whereas an increase in annual maximum flow is simulated in climate change scenarios developed from the RCP8.5 emission scenario. The study suggests optimal water management structures which can reduce the effect of change in high and low flows.
CD7 targeted “off-the-shelf” CAR-T demonstrates robust in vivo expansion and high efficacy in the treatment of patients with relapsed and refractory T-cell malignancies
Authors: Li Shiqi , Wang Xinxin , Luo Le , Liu Jia , Rao Jun , Liu Lin , Gao Li , Yuan Zhongtao , Li Yu , Li Gui , Wang Duanpeng , Li Sheng , He Jiaping , Zhang Lihua , Chen Lvzhe , Yin Ping , Li Chunmin , Li Xiaoping , Wang Youcheng , Dong Yancheng , Zhang Dingsong , Fang Lihua , Chen Yingnian , Shen Lianjun , Li Wenling , Cao Wei , Zhang Xi , Wang Sanbin 
Published: January 2023

Abstract
T-cell acute lymphoblastic leukemia (T-ALL) represents an area of high unmet medical needs. Once relapsed, patients have limited treatment options and usually a poor prognosis. T-ALL antigens such as CD7 is extensively expressed in normal T cells and natural killer (NK) cells, and extending the success of CAR-T therapy to T cell malignancies was challenged by CAR-T cell fratricide, the high production cost, long lagging time and potential product contaminations. GC027 is an “off-the-shelf” allogeneic CD7 targeted CAR-T therapeutic product for T cell malignancies. It demonstrated superior cell expansion and anti-leukemia efficacy in mouse xenograft model. In our previous study, we observed promising efficacy result in the first two r/r T-ALL patient treated with GC027. Deep and durable response in these two patients suggests the potential of a “off-the-shelf” allogeneic CAR-T product as a promising standalone therapy. In the expanded study, 11 out of 12 patients had extensive GC027 cell expansion, rapid eradication of T-lymphoblasts, and reached complete response within 1-month post infusion. At data cut-off of Nov. 30, 2022, 1 patient had progression free survival of > 3 years. With manageable toxicity profile, GC027 demonstrated superior clinical efficacy and durability in T cell malignancies.
Perinatal outcome of crash caesarean section under neuraxial anesthesia versus general anesthesia: a seven-year retrospective analysis
Authors: Shi Xueduo , Xu Chenyang , Wen Yazhou , Jiang Ming , Yu Huiling , Wang Xian , Yuan Hongmei , Feng Shanwu 
Published: January 2023

Abstract
Objective
The crash cesarean section (CS), which keeps extremely life-threatening to maternals or fetus, seems to be performed within adequate time horizon for the avoidance of negative feto-maternal denouement. The effective and vigilant technique of anesthesia remains vital for crash cesarean delivery. This study, hence, aims to validate the impact of various anesthesia tactics on the maternal as well as neonatal outcomes.
Method
This was a retrospective cohort study of parturient with the indication for crash CS with the assistance of general or neuraxial anesthesia during the period of January 2015 and July 2021 in our institution. The 1min Apgar score as primary outcome was documented. Secondary outcomes composing 5 min Apgar score, DDI, OAII, duration of operation, length of hospitalization, height and weight of newborn, use of vasopressors, blood loss were also measured.
Results
Of the total 536 subjects incorporated in the analysis, 337 crash CS were performed under general anesthesia (GA), 137 under epidural anesthesia (EA) and 65 under combined spinal-epidural anesthesia (CSE), respectively. The Apgar score of 1 min and 5 min in newborn receiving general anesthesia were lower than those under intraspinal anesthesia and no difference was found between EA and CSEA. The decision-to-delivery interval (DDI) of parturients under GA, EA, and CSE was 7[6,7], 6[6,7], and 14[11.5,20.5], respectively. DDI as well as decision to incision interval (DII) of GA and EA were shorter than CES, among which there was a similarity in DDI and DII between GA and EA. Compared to GA, the onset of anesthesia to incision interval (OAII) of intraspinal anesthesia was extended significantly. The birth height and weight of neonates from EA seem to be superior to GA.
Conclusion
Epidural anesthesia did not exploited negative impact on neonatal and maternal outcomes as compared to general anesthesia and could be utilized as an alternative to general anesthesia in crash cesarean section; in addition, the DDI of crash cesarean section could be achieved within 15 minutes under general or epidural anesthesia in our institution.
Effect of dried Leucaena leucocephala and Manihot esculenta supplementation leaves on feed intake, milk production, and milk composition of Holstein Friesian x Ankole crossbred cows
Authors: Barwani Didier Kichochi , Bacigale Samy Bashizi , Ayagirwe Rodriguez Basengere Balthazar , Gicheha Mathew Gitau , Katunga Dieudonné Musale , Osuga Isaac M. 
Published: January 2023

Abstract

This experiment was conducted to investigate the effect of dried Leucaena (Leucaena leucocephala) and cassava (Manihot esculenta) leaves on feed intake, milk production, and milk composition of Holstein Friesian x Ankole crossbred cows. Three cows in early lactation, with initial milk production of 4 ± 1.20 kg/day and 359 ± 24 kg average live body weight, were randomly assigned to the experimental diet in a 3x3 Latin square design. Three 15-day experimental periods were adopted (1 to 10-day: diet adaptation and 11 to 15-day: data collection). Cows were fed on a freshly chopped Guatemala grass diet supplemented with 1.25 kg DM of brewers’ spent grain (control). The experimental diets were similar to the control diet differing in the presence of dried Leucaena or cassava leaves, both at the inclusion rate of 20% of the basal diet intake. Total dry matter intake, nutrient intake, milk production, and milk composition showed significant variation among treatments. Cows supplemented with dried cassava leaves had higher total dry matter intake and organic matter intake. Leucaena significantly increased (p < 0.001) daily milk production by 15% compared to cassava (3%). Leucaena had a higher milk fat content (38.44 g), while cassava and the control diet had higher milk protein (38.53 and 38.43 g), lactose (56.79 g and 56.111 g), and not-fat solids (102.41 g and 101.27 g). These results indicate that dried Leucaena and cassava leaves can be used as protein supplements for Guatemala grass basal diet for crossbred cows to improve milk production and quality.
Language, Social, and Face Regions Are Affected in Toddlers with Autism and Predictive of Language Outcome
Authors: Duan Kuaikuai , Eyler Lisa , Pierce Karen , Lombardo Michael , Datko Michael , Hagler Donald , Taluja Vani , Zahiri Javad , Campbell Kathleen , Barnes Cynthia , Arias Steven , Nalabolu Srinivsa , Troxel Jaden , Courchesne Eric 
Published: January 2023

Abstract

Identifying prognostic early brain alterations is crucial for autism spectrum disorder (ASD). Leveraging structural MRI data from 166 ASD and 109 typical developing (TD) toddlers and controlling for brain size, we found that, compared to TD, ASD toddlers showed larger or thicker lateral temporal regions; smaller or thinner frontal lobe and midline structures; larger callosal subregion volume; and smaller cerebellum. Most of these differences were replicated in an independent cohort of 38 ASD and 37 TD toddlers. Moreover, the identified brain alterations were related to ASD symptom severity and cognitive impairments at intake, and, remarkably, they improved the accuracy for predicting later language outcome beyond intake clinical and demographic variables. In summary, brain regions involved in language, social, and face processing were altered in ASD toddlers. These early-age brain alterations may be the result of dysregulation in multiple neural processes and stages and are promising prognostic biomarkers for future language ability.
Changes in miR-134-3p expression and zDHHC3-AMPARs axis in association with aluminum neurotoxicity
Authors: Song Jing , Li Wenjing , Yuan Chunman , Gao Ting , Lu Xiaoting , Wang Linping , Niu Qiao 
Published: January 2023

Abstract
Aluminum (Al) is a neurotoxic substance associated with cognitive dysfunction and neurodegenerative diseases, such as Alzheimer’s disease, but the mechanisms for aluminum neurotoxicity remain to be identified. In this work, we try to investigate a novel potential biomarker of cognitive dysfunction following aluminum exposure and the mechanism involved. Recently, miR-134-3p was reported as a novel regulator of cognitive function. To address this, we investigate the expression level of miR-134-3p in plasma from 280 aluminum factory workers and analyzed the correlation between miRNA-134-3p, blood Al concentration, and Montreal Cognitive Assessment Scale (MoCA scale) score. The results implied that occupational aluminum exposure elevated miR-134-3p expression in the plasma of workers accompanied by cognitive impairment. Our experiment studies using both animal models and PC12 cells validated the up-regulation of miR-134-3p caused by aluminum. In addition, we identified that palmitoylation enzyme zDHHC3 was the target of miR-134-3p, and the decreasing AMPAR receptors (AMPARs) trafficking was related to the learning and memory impairment induced by aluminum. More importantly, using transfection and interference approaches in PC12 cells, inhibition of miR-134-3p resulted in a recovery of zDHHC3-AMPARs axis to a certain extent in response to aluminum. In summary, miR-134-3p was found to be involved in aluminum neurotoxicity by targeting zDHHC3-AMPARs axis and could serve as a potential biomarker or helpful target.
Serum neutrophil gelatinase associated lipocalin (NGAL) as a marker of activity in inflammatory bowel disease
Authors: Abozeid Fatma , Ali karim , Bahgat Monir , Borg Asmaa , Maher Maha 
Published: January 2023

Abstract
Inflammatory bowel disease (IBD) is a disease of activity and remission. Lipocalin 2 (LCN2), the coding gene for NGAL is one of the most over-expressed genes in the colonic mucosa in ulcerative colitis (UC) and crohn’s disease (CD). In our research we investigated the utility of serum level of Lipocalin 2 in assessing the activity of IBD. This was a single center case control study.It was conducted on 60 IBD patients, 50% (30 patients) were in remission and 50% were active.There were 28 healthy control. Patients with IBD either UC or CD were enrolled from IBD clinic Mansoura specialized medical Hospital, Egypt. All patients and control group were subjected to investigations including complete blood count (CBC) ,Erythrocyte Sedimentation Rate (ESR) ,C-reactive protein (CRP) and serum neutrophil gelatinase associated lipocalin (NGAL) by ELISA.Patients only were subjected to fecal calprotectin besides sigmoidoscopy or ileo-colonoscopy.The activity of IBD was assessed for UC by MAYO score and CD by CDAI. NGAL showed significant increase among active IBD patients by mean ± SD ng/ml (37.04 ± 9.63) than patients in remission (20.65 ± 4.35) (table 2) .It showed highly significant correlation with clinical and endoscopic activity of IBD r = 0.80, P < 0.0001(table 3). Serum NGAL can easily discriminate patients with active IBD from healthy controls with AUC 95% C.I = 1.00 (0.94-1.0), at the cutoff 18.52, P < 0.0001, with sensitivity 100% and specificity 100%. While AUC of NGAL which can discriminate patients with active IBD and those in remission at the cutoff 26.95 was 0.97, P < 0.0001, with sensitivity 93.3% and specificity 93.3% (Fig. 1 A,B). In relation to fecal calprotectin, there was highly significant correlation between fecal calprotectin and serum NGAL (r = 0.69, P < 0.0001).Both CRP and ESR were positively correlated to NGAL by r = 0.38 and r = 0.29 (P < 0.05) respectively. Serum NGAL can easily discriminate patients with active IBD from healthy controls as well as among patients in active or remission of IBD. NGAL in comparison to other markers as fecal calprotectin or CRP or ESR shows better statistical performance for activity of IBD. This clarifies its ability to be a highly significant predictor of activity of IBD besides its lower cost.
Butyrate Inhibits the Mitochondrial Complex Ι to Mediate Mitochondria Dependent Apoptosis of Cervical Cancer Cells
Authors: Zhang Ke , Ji Xiawei , Song Zhengyang , Yu Tiantian , Shi Dibang , Wang Fangyan , Xue Xiangyang , Guo Junping 
Published: January 2023

Abstract
Background
Cervical cancer (CC) is a common gynecological malignant tumor with high morbidity worldwide. Butyrate, a short-chain fatty acid produced by the intestinal flora, was reported to inhibit cervical carcinogenesis. This study aimed to further investigate the pro-apoptotic effects of butyrate on CC and the underlying mechanisms.
Methods
Human Hela and Caski cells were used in this study. Cell proliferation was assessed using CCK-8 and EdU staining. Cell migration and invasion were detected by Transwell and wound healing assay. The cell cycle, mitochondrial membrane potential and apoptosis were evaluated by flow cytometry. Reactive oxygen species (ROS) assay was performed for the mitochondrial function. Western blot and RT-qPCR were carried out to examine the related genes and proteins of mitochondrial complex Ι and apoptosis. The metabolite changes were analyzed by energy metabolomics and assay kits. The association between G protein-coupled receptor 41, 43, 109a and CC prognosis was analyzed using data from The Cancer Genome Atlas (TCGA).
Results
CCK-8 results showed that the butyrate treatment significantly inhibited the proliferation of CC cells, which was confirmed by EdU staining and cell cycle. The data of Transwell and wound healing assay unraveled that the migration of cervical cells was dramatically reduced after butyrate treatment. Additionally, the invasion was also observed to be decreased by butyrate. The western blot analysis showed that cleaved-Caspase 3 and cleaved-PARP, the executors of apoptosis, were increased by butyrate treatment. The results of Annexin V/PI staining and TUNEL also found the increase of apoptotic cells induced by butyrate. The expression of Cytochrome C, Caspase 9, BAX, but not Caspase 12 or 8, were up-regulated under butyrate exposure. The accumulated ROS was observed in butyrate-treated cells. Furthermore, energy metabolism showed that levels of mitochondrial NADH and NAD + decreased after butyrate treatment, which was consistent with the results of the NAD+/NADH Assay Kit. Western blot results also demonstrated that mitochondrial complex Ι reduced by butyrate.
Conclusions
Collectively, our results revealed that butyrate can inhibit the proliferation, migration and invasion of CC cells, and induce mitochondrial dependent apoptosis by inhibiting mitochondrial complex Ι.