bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microencapsulated phase change material through cellulose nanofibrils stabilized Pickering emulsion templating
Authors: Liu Wei , Lin Qingyi , Chen Siyu , Yang Hongbin , Liu Kun , Pang Bo , Xu Ting , Si Chuanling 
Published: August 2023

AbstractPhase change materials (PCMs) possess remarkable capability to store and release substantial amounts of energy during the processes of melting and crystallization across a wide temperature range, thus holding great promise in applications related to temperature regulation and thermal energy storage. Herein, to effectively address PCM leakage and enhance thermal conduction, PCM microcapsules with melamine–formaldehyde resin (MF) shell were prepared using in situ polymerization of Pickering emulsions stabilized by cellulose nanofibrils (CNFs). CNFs were selected as the stabilizers for the Pickering emulsions and as reinforcing nanofillers for the MF shell, owing to their excellent emulsifying capability, high mechanical strength, and sustainable nature. Paraffin wax (PW) was utilized as the PCM material. The resulting PCM microcapsules with MF resin shells and PW core had a diameter ranging from 2 to 4 µm. Results showed that microcapsule with the core–shell ratio of 2 (Micro-2.0) exhibited the highest latent heat of crystallization and latent heat of fusion, measuring approximately 128.40 J/g and 120.23 J/g, respectively. The encapsulation efficiency of Micro-2.0 was determined to be approximately 79.84%.
Mapping the integrity of rock mass with GPR: case study in decommissioning mining
Authors: Duz Beatriz Guzzo , Moreira César Augusto , Casagrande Matheus Felipe Stanfoca , Helene Livia Portes Innocenti 
Published: August 2023

AbstractSlopes are built for the purpose of extracting ore, in the case of mining, or access roads in civil works. The excavation of slopes in tropical countries is facilitated by the thick layer of soil formed from the more intense weathering when compared to other countries. However, the residence time of water in the soil is relatively longer and consequently allows the accumulation and percolation of water through rock fractures even in the dry period. These factors induce a greater probability of occurrence of ruptures. Mines in the decommissioning phase must guarantee slope stability conditions even after closure in order to comply with legislation and environmental safety. In this work, the slopes of a decommissioning mine were investigated using geophysical methods (GPR) and structural analysis of the rock mass. The results were presented in the form of radargrams that correlate distance and depth of investigation. Structural data served as the basis for the execution of kinematic analyzes for planar and wedge ruptures. The analysis of the results allowed the correlation between electromagnetic signal attenuation zones, with the presence of water and the occurrence of ruptures. Thus, the GPR results allowed the recognition of structural discontinuities, accumulation zones and water flow.
Anxiety and heart rate in a real-life class test in undergraduates choosing real-time or prerecorded oral presentations
Authors: Szabo Attila , Ábel Krisztina 
Published: August 2023

AbstractMost studies on acute stress stem from works conducted under artificial laboratory conditions. Inducing stress for experimental scrutiny is problematic and can be unethical. In this study, a ‘research methods’ course’s curriculum included a demonstration study testing anxiety and heart rate responses to the midterm test. Fifty-four university students (35 males and 19 females) presented a research topic in-person (n = 14) or prerecorded while being present (n = 40). Students selected a test format they could change until the week before the midterm test. The measures were trait anxiety, test anxiety, state anxiety, heart rate (HR), the last two being measured before and after examination, and grades. All students manifested decreased state anxiety and increased HR from before to after the test. Females exhibited higher HR and state anxiety than males. Real-time presentations were associated with higher HRs but not higher state anxiety. Those who changed their planned presentation mode from in-person to prerecorded exhibited higher test anxiety but not trait anxiety than those who presented as planned. Students who presented in-person obtained lower grades than those who prerecorded their presentations. Grades were negatively correlated with state anxiety after the test, but test anxiety did not significantly mediate the grades. Pre-test state anxiety was positively associated with both trait anxiety and test anxiety. The findings suggest that test anxiety is unlikely to affect grades, but test-anxious students need more control over academic evaluation. A choice in test format could be helpful in this regard.
On the Economics of the Transition to a Circular Economy
Authors: Chennak Ahmed , Giannakas Konstantinos , Awada Tala 
Published: August 2023

AbstractHumanity is facing complex challenges posed by population growth, climate change, and the need to increase food, feed, fiber, and bioenergy production while confronting the scarcity of natural resources. The transition to a circular economy, characterized by reduced resource use and waste, is being increasingly recognized in academic, business, and policy making circles as essential to meeting these challenges, with the emphasis being on the development of methods and processes that enable and facilitate the transition from a linear to a circular economy. This paper argues the need for an increased emphasis on the economics of the circular economy and presents a general framework that illustrates the transition from a linear to a circular economic system. In addition, the paper highlights the economic issues that arise during the transition to increased circularity and the policy options available to facilitate the successful transition to a more circular economic system.
A Fractional Perspective on the Dynamics of HIV, Considering the Interaction of Viruses and Immune System with the Effect of Antiretroviral Therapy
Authors: Tang Tao-Qian , Jan Rashid , Ahmad Hassan , Shah Zahir , Vrinceanu Narcisa , Racheriu Mihaela 
Published: August 2023

AbstractHIV infection is a worldwide health threat, necessitating a multifaceted strategy that includes prevention, testing, treatment and care. Moreover, it is essential to address the structural and social factors that influence the spread of this viral infection. In this study, we utilize fractional calculus to clarify the dynamics of HIV infection in vivo, specifically examining the interface amid the HIV and the immune system and taking into account the impact of antiretroviral therapy. We use important results from fractional theory to analyze our proposed model of HIV infection and developed a numerical scheme to depict the system’s dynamic behavior. By varying input factors, we were able to observe the system’s chaotic nature and track its trajectory, as well as examine the effect of viruses on T-cells. Our results reveal key factors affecting the system, and demonstrate the consequence of antiretroviral therapy on our proposed model of HIV. Moreover, we observe that the system’s strong non-linearity is responsible for the oscillation phenomena and identify the most sensitive parameters of the system.
A Finger in the Game: Sport-Specific Finger Strength Training and Onset of Injury
Authors: Sjöman Anna E. , Grønhaug Gudmund , Julin Mikko V. 
Published: August 2023

Introduction Strength training has proved to be an effective way to prevent injuries, but the evidence of the impact of strength training on finger injuries is lacking. A fingerboard is a sport-specific tool used by climbers for strength training of fingers. In this study, we searched for associations between fingerboard training and finger injuries in climbers with different lengths of climbing experience and levels of performance. Methods A web-based survey was used to collect information on self-perceived pain or injury in fingers (SPIIF) and regular fingerboard training (RFT). The survey was administered to the Finnish climbing community. Data were analyzed using contingency tables; chi-square was used to evaluate statistical significance. Results No significant correlations between SPIIF and RFT were found when analyzing all the participants (n=434) together. In climbers with 6 y or more in the sport, SPIIF was not common and RFT was negatively associated with SPIIF (χ2 [1, n=200]=4.57; P=0.03). In contrast to this, in male climbers who had been climbing for less than 6 y and had advanced to 7a level or higher (French lead/Font bouldering), SPIIF was common and RFT was positively associated with SPIIF (χ2 [1, n=75]=4.61; P=0.03). Conclusions We suggest that doing RFT may prevent SPIIF in climbers with a long background in the sport as fingerboard training can help build stronger fingers and thereby stronger tendons and ligaments. Climbers with fewer years in the sport and less adaptation to the fingers should be cautious with their training loads and RFT to avoid finger injuries and pain.
Developmental changes in cerebral NAD and neuroenergetics of an antioxidant compromised mouse model of schizophrenia
Authors: Skupienski Radek , Steullet Pascal , Do Kim Q. , Xin Lijing 
Published: August 2023

AbstractDefects in essential metabolic regulation for energy supply, increased oxidative stress promoting excitatory/inhibitory imbalance and phospholipid membrane dysfunction have been implicated in the pathophysiology of schizophrenia (SZ). The knowledge about the developmental trajectory of these key pathophysiological components and their interplay is important to develop new preventive and treatment strategies. However, this assertion is so far limited. To investigate the developmental regulations of these key components in the brain, we assessed, for the first time, in vivo redox state from the oxidized (NAD+) and reduced (NADH) form of Nicotinamide Adenine Dinucleotide (NAD), energy and membrane metabolites, inhibitory and excitatory neurotransmitters by 31P and 1H MRS during the neurodevelopment of an SZ animal model with genetically compromised glutathione synthesis (gclm-KO mice). When compared to age-matched wild type (WT), an increase in NAD+/NADH redox ratio was found in gclm-KO mice until early adulthood, followed by a decrease in full adults as observed in patients. Especially, in early postnatal life (P20, corresponding to childhood), levels of several metabolites were altered in gclm-KO mice, including NAD+, NAD+/NADH, ATP, and glutamine + glutamate, suggesting an interactive compensation for redox dysregulation between NAD, energy metabolism, and neurotransmission. The identified temporal neurometabolic regulations under deficits in redox regulation provide insights into preventive treatment targets for at-risk individuals, and other neurodevelopmental disorders involving oxidative stress and energetic dysfunction.
Heterogeneity in leukemia cells that escape drug-induced senescence-like state
Authors: Miller David , Kerkhofs Kyra , Abbas-Aghababazadeh Farnoosh , Madahar Sahib Singh , Minden Mark D. , Hébert Josée , Haibe-Kains Benjamin , Bayfield Mark A. , Benchimol Samuel 
Published: August 2023

AbstractErythropoietin (EPO) suppresses drug-induced apoptosis in EPO-receptor-positive leukemia cells and allows cells to persist after drug treatment by promoting cellular senescence. Importantly a small proportion of senescent cells can re-enter the cell cycle and resume proliferation after drug treatment, resulting in disease recurrence/persistence. Using a single-cell assay to track individual cells that exit a drug-induced senescence-like state, we show that cells exhibit asynchronous exit from a senescent-like state, and display different rates of proliferation. Escaped cells retain sensitivity to drug treatment, but display inter-clonal variability. We also find heterogeneity in gene expression with some of the escaped clones retaining senescence-associated gene expression. Senescent leukemia cells exhibit changes in gene expression that affect metabolism and senescence-associated secretory phenotype (SASP)-related genes. Herein, we generate a senescence gene signature and show that this signature is a prognostic marker of worse overall survival in AML and multiple other cancers. A portion of senescent leukemia cells depend on lysosome activity; chloroquine, an inhibitor of lysosome activity, promotes senolysis of some senescent leukemia cells. Our study indicates that the serious risks associated with the use of erythropoietin-stimulating agents (ESAs) in anemic cancer patients may be attributed to their ability to promote drug-tolerant cancer cells through the senescence program.
Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN
Authors: Zhang Xiaoling , Cong Xianling , Jin Xiangting , Liu Yu’e , Zhang Tong , Fan Xinyuan , Shi Xiyao , Zhang Xiaoying , Wang Xue , Yang Yong-Guang , Dai Xiangpeng 
Published: August 2023

AbstractThe transcription factor MYCN is frequently amplified and overexpressed in a variety of cancers including high-risk neuroblastoma (NB) and promotes tumor cell proliferation, survival, and migration. Therefore, MYCN is being pursued as an attractive therapeutic target for selective inhibition of its upstream regulators because MYCN is considered a “undruggable” target. Thus, it is important to explore the upstream regulators for the transcription and post-translational modification of MYCN. Here, we report that BRCA1-associated protein-1 (BAP1) promotes deubiquitination and subsequent stabilization of MYCN by directly binding to MYCN protein. Furthermore,BAP1knockdown inhibits NB tumor cells growth and migration in vitro and in vivo, which can be rescued partially by ectopic expression of MYCN. Importantly, depletion ofBAP1confers cellular resistance to bromodomain and extraterminal (BET) protein inhibitor JQ1 and Aurora A kinase inhibitor Alisertib. Furthermore, IHC results of NB tissue array confirmed the positive correlation between BAP1 and MYCN protein. Altogether, our work not only uncovers an oncogenic function of BAP1 by stabilizing MYCN, but also reveals a critical mechanism for the post-translational regulation of MYCN in NB. Our findings further indicate that BAP1 could be a potential therapeutic target for MYCN-amplified neuroblastoma.
The long transcript of lncRNA TMPO-AS1 promotes bone metastases of prostate cancer by regulating the CSNK2A1/DDX3X complex in Wnt/β-catenin signaling
Authors: Wang Min , Yin Chi , Wu Zhengquan , Wang Xinwen , Lin Qijun , Jiang Xingyu , Du Hong , Lang Chuandong , Peng Xinsheng , Dai Yuhu 
Published: August 2023

AbstractThe second most common male cancer is prostate cancer (PCa), which has a high tendency for bone metastasis. Long non-coding RNAs, including TMPO-AS1, play a crucial role in PCa progression. However, TMPO-AS1’s function in PCa bone metastasis (BM) and its underlying molecular mechanisms are unclear. Herein, we found that the long transcript of TMPO-AS1 (TMPO-AS1L) was upregulated in PCa tissues with bone metastasis, and overexpression of TMPO-AS1L correlated with advanced clinicopathological features and reduced BM-free survival in patients with PCa. Upregulated TMPO-AS1L promoted, whereas downregulated TMPO-AS1L inhibited, the PCa cell bone metastatic capacity in vitro and in vivo. Mechanistically, TMPO-AS1L was demonstrated to act as a scaffold, that strengthened the interaction of casein kinase 2 alpha 1 (CSNK2A1) and DEAD-box helicase 3 X-linked (DDX3X), and activated the Wnt/β-catenin signaling pathway, thus promoting BM of PCa. Moreover, upregulation of TMPO-AS1L in PCa resulted from transcription elongation modulated by general transcription factor IIF subunit 2 (GTF2F2). Collectively, our study provides critical insights into the role of TMPO-AS1L in PCa BM via Wnt/β-catenin signaling, identifying TMPO-AS1L as a candidate marker of PCa bone metastasis prognosis and therapeutic target.
Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation
Authors: Boogerd Cornelis J. , Perini Ilaria , Kyriakopoulou Eirini , Han Su Ji , La Phit , van der Swaan Britt , Berkhout Jari B. , Versteeg Danielle , Monshouwer-Kloots Jantine , van Rooij Eva 
Published: August 2023

AbstractThe inability of adult human cardiomyocytes to proliferate is an obstacle to efficient cardiac regeneration after injury. Understanding the mechanisms that drive postnatal cardiomyocytes to switch to a non-regenerative state is therefore of great significance. Here we show that Arid1a, a subunit of the switching defective/sucrose non-fermenting (SWI/SNF) chromatin remodeling complex, suppresses postnatal cardiomyocyte proliferation while enhancing maturation. Genome-wide transcriptome and epigenome analyses revealed that Arid1a is required for the activation of a cardiomyocyte maturation gene program by promoting DNA access to transcription factors that drive cardiomyocyte maturation. Furthermore, we show that ARID1A directly binds and inhibits the proliferation-promoting transcriptional coactivators YAP and TAZ, indicating ARID1A sequesters YAP/TAZ from their DNA-binding partner TEAD. In ischemic heart disease, Arid1a expression is enhanced in cardiomyocytes of the border zone region. Inactivation of Arid1a after ischemic injury enhanced proliferation of border zone cardiomyocytes. Our study illuminates the pivotal role of Arid1a in cardiomyocyte maturation, and uncovers Arid1a as a crucial suppressor of cardiomyocyte proliferation.
Modulatory dynamics of periodic and aperiodic activity in respiration-brain coupling
Authors: Kluger Daniel S. , Forster Carina , Abbasi Omid , Chalas Nikos , Villringer Arno , Gross Joachim 
Published: August 2023

AbstractBodily rhythms such as respiration are increasingly acknowledged to modulate neural oscillations underlying human action, perception, and cognition. Conversely, the link between respiration and aperiodic brain activity – a non-oscillatory reflection of excitation-inhibition (E:I) balance – has remained unstudied. Aiming to disentangle potential respiration-related dynamics of periodic and aperiodic activity, we applied recently developed algorithms of time-resolved parameter estimation to resting-state MEG and EEG data from two labs (total N = 78 participants). We provide evidence that fluctuations of aperiodic brain activity (1/f slope) are phase-locked to the respiratory cycle, which suggests that spontaneous state shifts of excitation-inhibition balance are at least partly influenced by peripheral bodily signals. Moreover, differential temporal dynamics in their coupling to non-oscillatory and oscillatory activity raise the possibility of a functional distinction in the way each component is related to respiration. Our findings highlight the role of respiration as a physiological influence on brain signalling.
A stretchable, mechanically robust polymer exhibiting shape-memory-assisted self-healing and clustering-triggered emission
Authors: Wang Xiaoyue , Xu Jing , Zhang Yaoming , Wang Tingmei , Wang Qihua , Li Song , Yang Zenghui , Zhang Xinrui 
Published: August 2023

AbstractSelf-healing and recyclable polymer materials are being developed through extensive investigations on noncovalent bond interactions. However, they typically exhibit inferior mechanical properties. Therefore, the present study is aimed at synthesizing a polyurethane–urea elastomer with excellent mechanical properties and shape-memory-assisted self-healing behavior. In particular, the introduction of coordination and hydrogen bonds into elastomer leads to the optimal elastomer exhibiting good mechanical properties (strength, 76.37 MPa; elongation at break, 839.10%; toughness, 308.63 MJ m−3) owing to the phased energy dissipation mechanism involving various supramolecular interactions. The elastomer also demonstrates shape-memory properties, whereby the shape recovery force that brings damaged surfaces closer and facilitates self-healing. Surprisingly, all specimens exhibite clustering-triggered emission, with cyan fluorescence is observed under ultraviolet light. The strategy reported herein for developing multifunctional materials with good mechanical properties can be leveraged to yield stimulus-responsive polymers and smart seals.
Atmospheric turbulence strength distribution along a propagation path probed by longitudinally structured optical beams
Authors: Zhou Huibin , Su Xinzhou , Duan Yuxiang , Song Hao , Zou Kaiheng , Zhang Runzhou , Song Haoqian , Hu Nanzhe , Tur Moshe , Willner Alan E. 
Published: August 2023

AbstractAtmospheric turbulence can cause critical problems in many applications. To effectively avoid or mitigate turbulence, knowledge of turbulence strength at various distances could be of immense value. Due to light-matter interaction, optical beams can probe longitudinal turbulence changes. Unfortunately, previous approaches tended to be limited to relatively short distances or large transceivers. Here, we explore turbulence probing utilizing multiple sequentially transmitted longitudinally structured beams. Each beam is composed of Bessel-Gaussian ($${{{{{{\rm{BG}}}}}}}_{{{{{{\mathcal{l}}}}}}{{=}}0,{k}_{z}}$$

BG

l
=
0
,

k

z

) modes with different $${k}_{z}$$

k

z

values such that a distance-varying beam width is produced, which results in a distance- and turbulence-dependent modal coupling to $${{{{{\mathcal{l}}}}}}{{{{{\mathscr{\ne }}}}}}0$$
l
{{\relax \special {t4ht̂3)}\o:mathrel: {\unhbox \voidb@x \special {t4ht@+{38}{35}x2260;}x}}}
0
orders. Our simulation shows that this approach has relatively uniform and low errors (<0.3 dB) over a 10-km path with up to 30-dB turbulence-structure-constant variation. We experimentally demonstrate this approach for two emulated turbulence regions (~15-dB variation) with <0.8-dB errors. Compared to previous techniques, our approach can potentially probe longer distances or require smaller transceivers.
Electro-assisted methane oxidation to formic acid via in-situ cathodically generated H2O2 under ambient conditions
Authors: Kim Jiwon , Kim Jae Hyung , Oh Cheoulwoo , Yun Hyewon , Lee Eunchong , Oh Hyung-Suk , Park Jong Hyeok , Hwang Yun Jeong 
Published: August 2023

AbstractDirect partial oxidation of methane to liquid oxygenates has been regarded as a potential route to valorize methane. However, CH4 activation usually requires a high temperature and pressure, which lowers the feasibility of the reaction. Here, we propose an electro-assisted approach for the partial oxidation of methane, using in-situ cathodically generated reactive oxygen species, at ambient temperature and pressure. Upon using acid-treated carbon as the electrocatalyst, the electro-assisted system enables the partial oxidation of methane in an acidic electrolyte to produce oxygenated liquid products. We also demonstrate a high production rate of oxygenates (18.9 μmol h−1) with selective HCOOH production. Mechanistic analysis reveals that reactive oxygen species such as ∙OH and ∙OOH radicals are produced and activate CH4 and CH3OH. In addition, unstable CH3OOH generated from methane partial oxidation can be additionally reduced to CH3OH on the cathode, and so-produced CH3OH is further oxidized to HCOOH, allowing selective methane partial oxidation.