bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ability of minimally invasive surgery to decrease incisional surgical site infection occurrence in patients with colorectal cancer and other gastroenterological malignancies
Authors: Yamamoto Takehito , Yoshitomi Mami , Oshimo Yoshiki , Nishikawa Yuta , Hisano Koji , Nakano Kenzo , Kawai Takayuki , Okuchi Yoshihisa , Iguchi Kohta , Tanaka Eiji , Fukuda Meiki , Taura Kojiro , Terajima Hiroaki 
Published: April 2023

BackgroundSurgical site infection (SSI) is one of the most important complications of surgery for gastroenterological malignancies because it leads to a prolonged postoperative hospital stay and increased inpatient costs. Furthermore, SSI can delay the initiation of postoperative treatments, including adjuvant chemotherapy, negatively affecting patient prognosis. Identifying the risk factors for SSI is important to improving intra- and postoperative wound management for at-risk patients.MethodsPatients with gastroenterological malignancies who underwent surgery at our institution were retrospectively reviewed and categorized according to the presence or absence of incisional SSI. Clinicopathological characteristics such as age, sex, body mass index, malignancy location, postoperative blood examination results, operation time, and blood loss volume were compared between groups. The same analysis was repeated of only patients with colorectal malignancies.ResultsA total of 528 patients (330 men, 198 women; mean age, 68 ± 11 years at surgery) were enrolled. The number of patients with diseases of the esophagus, stomach, small intestine, colon and rectum, liver, gallbladder, and pancreas were 25, 150, seven, 255, 51, five, and 35, respectively. Open surgery was performed in 303 patients vs. laparoscopic surgery in 225 patients. An incisional SSI occurred in 46 patients (8.7%). Multivariate logistic regression analysis showed that postoperative hyperglycemia (serum glucose level ≥140 mg/dl within 24 h after surgery), colorectal malignancy, and open surgery were independent risk factors for incisional SSI. In a subgroup analysis of patients with colorectal malignancy, incisional SSI occurred in 27 (11%) patients. Open surgery was significantly correlated with the occurrence of incisional SSI (P = 0.024).ConclusionsPostoperative hyperglycemia and open surgery were significant risk factors for SSI in patients with gastroenterological malignancies. Minimally invasive surgery could reduce the occurrence of incisional SSI.
Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report
Authors: Wang Lu , Liu Ping , Duan Hui , Li Pengfei , Su Guidong , Li Weili , Liang Cong , Chen Chunlin 
Published: April 2023

ObjectiveTo compare survival outcomes of type B radical hysterectomy (RH) and type C RH in patients with early-stage cervical cancer.MethodsWe retrospectively identified continuous cervical cancer patients with FIGO stage IA2-IB2 and IIA1 who underwent either type B RH (n = 278) or type C RH (n = 148) performed by the same group of surgeons between 2009 and 2018. Propensity score matching was carried out to minimize selection biases. Intraoperative photographs, immediate postoperative questionnaire and specimen measurements were used to accurately determine the extensive of surgery. We further narrowed the study population to patients with specific histological subtypes and patients with deep stromal invasion.ResultsThe median follow-up period was 42.41 ± 24.60 months. After adjusting, no differences in the 5-year overall survival (OS) and disease-free survival (DFS) were found between the type B group and the type C group (OS: 87.8% vs. 89.4%, P = 0.814; DFS: 84.9% vs. 85.6%, P = 0.898). In further analysis of patients with squamous-cell carcinoma, adenocarcinoma, adenosquamous carcinoma, similar 5-year OS and DFS rates were found between two groups (OS: 88.7% vs. 97.1%, P = 0.250; DFS: 84.7% vs. 92.3%, P = 0.541). Consistent results were found in patients with deep stromal invasion (OS: 81.8% vs. 100%, P = 0.144; DFS: 82.8% vs. 100%, P = 0.128).ConclusionsType B RH could be used to treat FIGO stage IA2-IB2 and IIA1 cervical cancer to get equivalent 5-year OS and DFS. Further randomized controlled trials are warranted.
COVID-19 measures as an opportunity to reduce the environmental footprint in orthopaedic and trauma surgery
Authors: Arndt Eva-Maria , Jansen Tom Rainer , Bojko Jessica , Roos Jonas Joachim , Babasiz Mari , Randau Thomas Martin , Welle Kristian , Burger Christof , Kabir Koroush 
Published: April 2023

BackgroundClimate change and its consequences on our everyday life have also tremendous impacts on public health and the health of each individual. The healthcare sector currently accounts for 4.4% of global greenhouse gas emissions. The share of the emissions in the health care system caused by the transportation sector is 7%. The study analyses the effect of video consultation on the CO2 emissions during the Covid-19 pandemic in an outpatient clinic of the department of orthopaedics and traumatology surgery at a German university hospital.MethodsThe study participants were patients who obtained a video consultation in the period from June to December 2020 and voluntarily completed a questionnaire after the consultation. The type of transport, travel time and waiting time as well as patient satisfaction were recorded by questionnaire.ResultsThe study comprised 51 consultations. About 70% of respondents would have travelled to the clinic by car. The reduction in greenhouse gas emissions of video consultations compared to a face-to-face presentation was 97% in our model investigation.ConclusionThe video consultation can be a very important part of the reduction of greenhouse gas emissions in the health care system. It also saves time for the doctor and patient and can form an essential part of individual patient care.
Thyroglobulin Value Predict Iodine-123 Imaging Result in Differentiated Thyroid Cancer Patients
Authors: Campennì Alfredo , Ruggeri Rosaria Maddalena , Siracusa Massimiliano , Romano Davide , Giacoppo Giulia , Crocè Ludovica , Rosarno Helena , Russo Simona , Cardile Davide , Capoccetti Francesca , Alibrandi Angela , Baldari Sergio , Giovanella Luca 
Published: April 2023

Background: In differentiated thyroid cancer (DTC) patients, the response to initial treatments is evaluated 6–12 months after radioiodine therapy (RIT) according to the 2015 American Thyroid Association (2015 ATA) criteria. In selected patients, diagnostic 131-radioiodine whole-body scintigraphy (Dx-WBS) is recommended. We evaluated the diagnostic performance of 123I-Dx-WBS-SPECT/CT imaging in detecting incomplete structural responses in the early follow-up of DTC patients and, additionally, derived optimized basal-Tg value as a yardstick for scintigraphic imaging. Methods: We reviewed the records of 124 low or intermediate-risk DTC patients with negative anti-thyroglobulin antibody. All patients had undergone (near)-total-thyroidectomy followed by RIT. The response to initial treatments was evaluated 6–12 months after RIT. Results: According to the 2015 ATA criteria, 87, 19 and 18 DTC patients were classified to have excellent response (ER), indeterminate/incomplete biochemical response (BIndR/BIR) or structural incomplete response (SIR), respectively. Among patients with less than ER, 18 had a positive 123I-Dx-WBS-SPECT/CT. Metastatic disease at 123I-Dx-WBS-SPECT/CT mainly involved lymph nodes within the central compartment, and corresponding neck ultrasound examinations were negative. The ROC curve analysis was performed to define the best basal-Tg cut-off (i.e., 0.39 ng/mL; AUC = 0.852) able to discriminate patients with and without positive 123I-Dx-WBS-SPECT/CT, respectively. The overall sensitivity, specificity, accuracy, PPV and NPV were 77.8%, 89.6%, 87.9%, 56.0% and 95.9%, respectively. Basal-Tg cut-off was an independent risk factor for having a positive 123I-Dx-WBS-SPECT/CT. Conclusion: 123I-Dx-WBS-SPECT/CT identified lymph node metastases in 14/37 patients with less than ER and a negative neck ultrasound, thus modifying the management of such patients. The diagnostic performance of 123I-Dx-WBS-SPECT/CT significantly increased in patients with basal-Tg values ≥ 0.39 ng/mL.
Genome-Wide Identification, Evolution, and Expression Analyses of AP2/ERF Family Transcription Factors in Erianthus fulvus
Authors: Qian Zhenfeng , Rao Xibing , Zhang Rongqiong , Gu Shujie , Shen Qingqing , Wu Huaying , Lv Shaozhi , Xie Linyan , Li Xianli , Wang Xianhong , Chen Shuying , Liu Lufeng , He Lilian , Li Fusheng 
Published: April 2023

The AP2/ERF transcription factor family is one of the most important gene families in plants and plays a vital role in plant abiotic stress responses. Although Erianthus fulvus is very important in the genetic improvement of sugarcane, there are few studies concerning AP2/ERF genes in E. fulvus. Here, we identified 145 AP2/ERF genes in the E. fulvus genome. Phylogenetic analysis classified them into five subfamilies. Evolutionary analysis showed that tandem and segmental duplication contributed to the expansion of the EfAP2/ERF family. Protein interaction analysis showed that twenty-eight EfAP2/ERF proteins and five other proteins had potential interaction relationships. Multiple cis-acting elements present in the EfAP2/ERF promoter were related to abiotic stress response, suggesting that EfAP2/ERF may contribute to adaptation to environmental changes. Transcriptomic and RT-qPCR analyses revealed that EfDREB10, EfDREB11, EfDREB39, EfDREB42, EfDREB44, EfERF43, and EfAP2-13 responded to cold stress, EfDREB5 and EfDREB42 responded to drought stress, and EfDREB5, EfDREB11, EfDREB39, EfERF43, and EfAP2-13 responded to ABA treatment. These results will be helpful for better understanding the molecular features and biological role of the E. fulvus AP2/ERF genes and lay a foundation for further research on the function of EfAP2/ERF genes and the regulatory mechanism of the abiotic stress response.
Plasmasphere Refilling after the 1 June 2013 Geomagnetic Storm
Authors: Del Corpo Alfredo , Vellante Massimo 
Published: April 2023

Plasma content and distribution are key parameters in the dynamics of the inner magnetosphere. The plasmasphere contributes, for the most part, to the plasma mass density, and its properties are very dependent on the history of the magnetosphere and geomagnetic activity. In this work, we investigated plasmasphere dynamics and plasmasphere–ionosphere coupling, focusing on the refilling process that followed the geomagnetic storm that occurred on 1 June 2013. The equatorial plasma mass density used to evaluate the refilling rates was remotely sensed by observation of the field line resonance (FLR) frequencies of the geomagnetic field, driven by ultra-low-frequency magnetic waves. The FLR frequencies were retrieved by performing an analysis of signals detected by several station pairs of the European quasi-Meridional Magnetometer Array. We estimated the rate at which the refilling process occurred, concentrating on both the diurnal and the day-to-day refilling rates. The estimated contraction rate during the main phase of the storm was higher than ∼3.5 REd−1, while the average expansion rate was ∼0.4 REd−1. We investigated the radial dependence of the refilling rates, using a novel approach based on fit plasma mass density profiles, and we related their variation to the plasmasphere boundary layer and the zero-energy Alfvén boundary. We found evidence supporting the idea that flux tubes mapping in the region between these two boundaries experience an enhanced refilling process.
TREATMENT OF PURULOUS-INFLAMMATORY COMPLICATIONS OF INJURIES AND DISEASES OF PELVIC BONES
Authors: Trufanov I. I. , Klyatsky Yu. P. , Tribushny O. V. , Kosilo V. V. , Klyatskа L. I. , Yurchenko P. G. 
Published: April 2023

Summary. Purulent-inflammatory complications of fractures of pelvic bones represent up to currently one of the most difficult and little-studied sections of traumatology. Complexity anatomical structure and topographic relations of the pelvic region, deep location a significant part of the bones under the muscle mass create objective difficulties for surgical treatment of bone damage and later in the diagnosis of purulent processes. Osteomyelitis of the pelvis is accompanied by high mortality and is from 2.5 to 52% as in acute and in the chronic stage of the disease.
Purpose: by analyzing clinical mistakes and the possibility of purulent-inflammatory complications during operative treatment and postoperative management of patients with fractures bones of the pelvis, as well as to determine methods of diagnosis, treatment and ways of prevention traumatic sacroiliitis.
Materials and methods. In the period from 2017 to 2022 in the bone-purulent surgery department of Zaporizhzhia city clinical hospital №9 treated 9 patients with purulent processes in of the pelvic region, 6 (66.3%) of them were men, and 3 (33.4%) were women. With postoperative osteomyelitis, which occurred after osteosynthesis with plates of multiple pelvic bone fractures, 4 (44.5%) patients were treated. Conservative therapy with sacroiliitis, the cause of which was abortion, received by 2 (22.2%) women, 1 (11.1%) patient suffered from right-sided sacroiliitis since childhood and repeatedly operated, and 2 (22.2%) men were treated with cause of sacroiliitis, which occurred after slaughter of the sacroiliac joint area.
Results. All patients who were treated in the bone-purulent surgery department for purulent-inflammatory processes of pelvic bones, recovered and were discharged for outpatient treatment. While treatment in the ward, patients received complex treatment, which included conservative therapy and surgical intervention. Despite the introduction of modern methods of treatment of osteomyelitis of the pelvis, a trend of steady growth in the number is noted exits of patients with disabilities, which is confirmed by world statistics.
Conclusions. Lack of hard fixation of bone fragments by implants increases the risk of purulent complications in the postoperative period. Use of additional diagnostic methods and complex treatment, which includes radical purulent sanitation foci, creation of favorable conditions for tissue regeneration, prevention of relapses suppuration, targeted antibacterial therapy, correction of homeostasis indicators and increases the protective forces of the body during purulent processes of the bones and joints of the pelvis achieving positive results in 80.2% of patients.
Reasons for unsatisfactory results of treatment of destructive forms of erysipelas
Authors: Shapoval S. D. 
Published: April 2023

Goal. Find out the cause of unsatisfactory treatment outcomes in patients with destructive forms of erysipelas.
Materials and methods. Retrospectively and prospectively analyzed 284 case histories of patients who were hospitalized in the center of purulent - septic surgery KNP "City Hospital G3" Zaporizhzhia for the period 2016-2022.
Results. It was found that most often the local focus was localized on the upper and lower extremities. The most common clinical manifestations of intoxication in bullous and phlegmonous forms of erysipelas were: general weakness, hyperthermia, muscle pain. In the necrotic form of erysipelas, patients showed signs of severe intoxication with nausea, vomiting and confusion. In the complex treatment of patients with erysipelas, the main place belongs to the early surgical treatment of the area of ​​the pathological process and antibiotic therapy (ABT).
Conclusions. Radical surgery and timely targeted ABT are key elements of success in the treatment of surgical forms of erysipelas and are not subject to revision. The main causes of unsatisfactory consequences in patients with erysipelas are: late referral of patients to the hospital, aggravation of the disease at the time of hospitalization by septic shock and multiple organ failure, severe decompensated comorbidities.
EFEKTIVITAS PEMBERIAN AIR REBUSAN JAHE TERHADAP EMESIS GRAVIDARUM PADA IBU HAMIL TRIMESTER I
Authors: LESTARI NURUL AULIA DEVY , DWI ANJANI ARUM , UTAMI RISQI , Prima Lydia Berty 
Published: April 2023

Emesis gravidarum merupakan keluhan yang sering dirasakan pada kehamilan trimester I, hal ini disebabkan adanya perubahan hormon, hal ini dapat menjadi Hyperemesis Gravidarum yang dapat menggaggu aktivitas, gangguan nutrisi, ketidak seimbangan elektrolit, dehidrasi dan penurunan berat badan. Air rebusan Jahe merupakan salah satu penatalaksanaan non farmakologis untuk emesis gravidarum, kandungan minyak astiri dan gingreol dalam jahe dapat menimbilkan efek menyegarkan dan menghambat reflek muntah. Tujuan dari penelitian ini adalah untuk mengetahui efektifitas air rebusan jahe terhadap emesis gravidarum pada ibu hamil trimester 1. Penelitian ini merupakakan penelitian pra eksperimen dengan rancangan one group pretest-posttest, Penelitian dilakukan pada bulan Juli 2019 di Puskesmas Tanjung Unggat. Populasi dalam penelitian ini adalah ibu hamil trimester 1 yang mengalami emesis gravidarum dengan jumlah sampel 34 orang. Instrumen penelitian menggunakan lembar observasi dan di analisa dengan independent T-test.. Hasil penelitian menunjukan bahwa rerata emesis gravidarum sebelum diberikan air rebusan jahe adalah 11,71 dan rerata emesis gravidarum setelah diberikan air rebusan jahe adalah 5,12. Hasil analisa data dengan menggunakan paired sample t-test didapat p-value 0,000 (p < 0,05), sehingga Ho ditolak dan dapat disimpulkan bahwa pemberian air rebusan jahe efektif terhadap penurunan emesis gravidarum. Rekomendasi terhadap tenaga kesehatan agar dapat memberi informasi kepada ibu hamil tentang cara dan dosis air rebusan jahe yang aman dikonsusmsi untuk menurunkan mual muntah.
Keefektifan Model Jigsaw Dan STAD Terhadap Pencapaian Karakter Dan Kemampuan Numerasi Siswa Kelas V SD
Authors: Kustantina  
Published: April 2023

In the learning process in class V SDN Karanggeneng 02, the students' character achievement and students' numeracy skills were still low. This condition was improved through the use of innovative learning models. The researcher aimed to determine the effectiveness of the Jigsaw and STAD learning models on the character and numeracy achievement of fifth grade students. This research is an experimental research with a learning observation research design and pretest posttest. The samples in this study were the VA class using the Jigsaw learning model and the VB class using the STAD learning model. The data obtained from the results of the research were analyzed using a statistical test, then the t-test results were carried out. From the results of the analysis and tests, this study showed a significant difference in effectiveness. In the Jigsaw model, the level of effectiveness is 77.02%, while in the STAD model it is 48.32%. So that it can be stated that the Jigsaw learning model is more effective in achieving the character and numeracy abilities of fifth grade elementary school students.

Dalam proses pembelajaran di kelas V SDN Karanggeneng 02 pencapaian karakter siswa dan kemampuan numerasi siswa masih rendah.Kondisi tersebut diperbaiki melalui penggunaan model pembelajaran yang inovatif.Peneliti bertujuan mengetahui keefektifan model pembelajaran Jigsaw dan STAD terhadap pencapaian karakter dan numerasi siswa kelas V . Penelitian ini merupakan penelitian eksperimen dengan desain penelitian observasi pembelajaran dan pretes posttes.Sempel dalam penelitian ini adalah kelas VA menggunakan model pembelajaran Jigsaw dan kelas VB menggunakan model pembelajaran STAD. Perolehan data dari hasil penelitian dianalisis menggunakan Uji statistic,selanjutnya dilakukan Uji-t hasil. Dari hasil analisis dan uji tersebut penelitian ini menunjukkan tingkat perbedaan keefektifan yang signifikan. Pada model Jigsaw tingkat keefektifannya 77,02% sedangkan model STAD 48,32%. Sehingga dapat dinyatakan model pembelajaran Jigsaw lebih efektif terhadap pencapaian karakter dan kemampuan numerasi siswa kelas V SD.
The Development of Military Medicine in the Era of the «Military Revolution in Europe» in France
Authors: Ovchinnikov Vladimir 
Published: April 2023

The subject of the study is the main aspects of the formation of the military medical service of the French Kingdom of the epoch of the Great Century. The purpose of the review is to demonstrate the integration of the Institute of military Medicine into the ideological machine of the Sun King. The author pays attention to the political, economic and socio-cultural aspects of this process, which took place against the background of the formation of absolutism as a military-political concept.
The author demonstrates the transformation of military medicine as a specific sociocultural practice into an integral part of the life of the French army of the era of the military revolution, which was primarily an element of propaganda, which was associated with the regular actualization of the thesis that the actions of doctors are an act of goodwill on the part of the crown, as well as the supply of units, clothing provisions and ammunition. This increased the morale of the troops, despite the removal
from the camps of the baggage women, who had already received the idyllic name "Aphrodite's army" at that time. The characterized phenomenon is presented in the article as an example of the instrumentalization of the ancient (in particular, the Ro-
man heritage), which is an integral part of the transformation of the military and political mechanisms of European political states. In many ways, an unobvious manifestation of this process is the widespread introduction of the simplest sanitary and hygienic standards into army use, such as, for example, the use of a block system for the location of the main components of the camp, which made its structure more orderly and efficient.
Historical Novels by B. Okudzhava: Some Aspects of Artistic Anthropology
Authors: Matyushkina Ekaterina 
Published: April 2023

The subject of the study in the article is literary anthropology, which is reflected in the historical prose of B. Okudzhava. The purpose of the analysis is to study some aspects of the literary anthropology of B. Okudzhava's historical novels. The
methodology of the research is determined by the nature of the tasks set and is based on the historical-literary, socio-cultural method, as well as a holistic analysis of the work of art.
The conclusions of the research characterize some principles of literary anthropology of B. Okudzhava: 1) for B. Okudzhava, the main carrier and measure of spiritual values is the Russian intelligentsia, while history in his novels acts as a con-
text for moral verification of personality; 2) one of the most important ontological constants of human existence for B. Okudzhava is hope, invisibly present in life; 3) the human being of B. Okudzhava is characterized by ideas about conditionality,
predestination and the inevitability of events and actions; 4) through all the novels of B. Okudzhava's leitmotif is the idea that there is no independent human freedom outside of history, and significant historical events cannot remain external even to an
unwitting witness to them; 5) B. Okudzhava's spiritual and moral being of a person is defined by responsibility, interpreted as a person's awareness of his or her place in history and society, as well as the ability of a person to be responsible for his or
her actions and feel involved in the events taking place.
The results of the research conducted in this article can be used in the study of B. Okudzhava's creativity and historical prose of the second half of the XX century.
The main conclusions can be used in the preparation of lecture courses.