bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole-genome sequencing of multidrug resistance Salmonella Typhi clinical strains isolated from Balochistan, Pakistan
Authors: Fatima Sareen , Ishaq Zaara , Irfan Muhammad , AlAsmari Abdullah F. , Achakzai Jahangir Khan , Zaheer Tahreem , Ali Amjad , Akbar Ali 
Published: May 2023

IntroductionSalmonella enterica serovar Typhi (S. Typhi) is a major cause of morbidity and mortality in developing countries, contributing significantly to the global disease burden.MethodsIn this study, S. Typhi strains were isolated from 100 patients exhibiting symptoms of typhoid fever at a tertiary care hospital in Pakistan. Antimicrobial testing of all isolates was performed to determine the sensitivity and resistance pattern. Three MDR strains, namely QS194, QS430, and QS468, were subjected to whole genome sequencing for genomic characterization.Results and DiscussionMLST analysis showed that QS194, belonged to ST19, which is commonly associated with Salmonella enterica serovar typhimurium. In contrast, QS430 and QS468, belonged to ST1, a sequence type frequently associated with S. Typhi. PlasmidFinder identified the presence of IncFIB(S) and IncFII(S) plasmids in QS194, while IncQ1 was found in QS468. No plasmid was detected in QS430. CARD-based analysis showed that the strains were largely resistant to a variety of antibiotics and disinfecting agents/antiseptics, including fluoroquinolones, cephalosporins, monobactams, cephamycins, penams, phenicols, tetracyclines, rifamycins, aminoglycosides, etc. The S. Typhi strains possessed various virulence factors, such as Vi antigen, Agf/Csg, Bcf, Fim, Pef, etc. The sequencing data indicated that the strains had antibiotic resistance determinants and shared common virulence factors. Pangenome analysis of the selected S. Typhi strains identified 13,237 genes, with 3,611 being core genes, 2,093 shell genes, and 7,533 cloud genes. Genome-based typing and horizontal gene transfer analysis revealed that the strains had different evolutionary origins and may have adapted to distinct environments or host organisms. These findings provide important insights into the genetic characteristics of S. Typhi strains and their potential association with various ecological niches and host organisms.
A systematic review of the ecological, social and economic sustainability effects of community-supported agriculture
Authors: Egli Lukas , Rüschhoff Judith , Priess Jörg 
Published: May 2023

IntroductionCommunity-supported agriculture (CSA) offers a high potential to provide synergies between ecological, economic and social sustainability aspects. While CSA is still in a niche, it has experienced rapid growth and increasing interest during the last years. An overview of sustainability impacts of CSA based on quantitative empirical work is missing, which is needed for well-informed and targeted policies and funding, as well as to tackle research gaps.MethodsHere we reviewed the literature to systematically assess empirical and quantitative findings regarding sustainability outcomes of CSA at different levels.ResultsWe found that &lt; 30% of the 39 studies included assessed ecological sustainability aspects. If CSA farms were compared to reference systems, they mostly performed better with regard to resource use efficiency and greenhouse gas emissions. The majority of studies evaluated social aspects. While many studies showed that CSA yet fails to reach low-income households, and therefore members do not represent the average population, CSA membership improves health and sustainability behavior. Economic variables were assessed in more than half of the considered studies, but knowledge on the relative performance remains scarce. Nevertheless, first studies indicate high economic viability.DiscussionOur review suggests a largely positive performance of CSA with regard to sustainability. Accordingly, if CSA would reach a bigger share in the food system, it could contribute to a transformation toward sustainable food systems. To address important knowledge gaps, we recommend the consideration of more and particularly ecological sustainability aspects, comparisons across different farming and marketing systems and the integration of knowledge from different sources such as theses and practical knowledge documented in various languages in different parts of the world.
Case report: Interdisciplinary treatment of complex C1/C2 fractures in a patient with concomitant three-vessel coronary artery disease requiring bypass surgery
Authors: Di Francesco M. E. , Magunia H. , Örgel A. , Tatagiba M. , Radwan M. , Adib S. D. 
Published: May 2023

BackgroundAcute myocardial infarction (MI) frequently leads to consciousness disturbance following hemodynamic collapse. Therefore, MI can occur together with upper cervical spine trauma. Herein, we report the successful treatment of complex C1/C2 fractures in a patient with concomitant three-vessel coronary artery disease (CAD).Case presentationA 70-year-old patient presented in our emergency outpatient clinic after a hemodynamic collapse without neurological deficits or heart-related complaints. Computed tomography (CT) scan of the cervical spine revealed a dislocated odontoid fracture Anderson and D'Alonzo type II and an unstable Gehweiler type III injury (Jefferson's fracture). An intradiploic arachnoid cyst in the posterior wall of the posterior fossa was a coincident radiological finding. Furthermore, coronary angiography confirmed three-vessel CAD with high-grade coronary artery stenosis. Indication for upper cervical spine surgery and bypass surgery was given. An interdisciplinary team of neurosurgeons, cardiothoracic surgeons and anesthesiologists evaluated the patient's case to develop the most suitable therapy concept and alternative strategies. Finally, in first step, C1-C2 fusion was performed by Harms technique under general anesthesia with x-ray guidance, spinal neuronavigation, Doppler ultrasound and cardiopulmonary monitoring. Cardiothoracic surgeons were on standby. One month later bypass surgery was performed uneventfully. Follow-up CT scan of cervical spine revealed intraosseous screw positioning and beginning fusion of the fractures. The patient did not develop neurological deficits and recovered completely from both surgeries.ConclusionsTreating complex C1/C2 fractures with concomitant severe CAD requiring treatment is challenging and carries a high risk of complications. To our knowledge, the literature does not provide any guidelines regarding therapy of this constellation. To receive upper cervical spine stability and to prevent both, spinal cord injury and cardiovascular complications, an individual approach is required. Interdisciplinary cooperation to determine optimal therapeutic algorithms is needed.
Sosialisasi dan Penyuluhan Sadar Wisata Pada Pengembangan Kampung Wisata Baluwarti Sebagai Kampung Wisata Menuju Pariwisata Budaya di Kota Surakarta
Authors: Marimin Marimin , Adiwijaya Deria , Wijayanto Nanang , Prasetyo Jimmi , Afgiyanto Tommi 
Published: May 2023

ABSTRACT
Tourism is part of the field of economic activity that has a multiplier effect, not only providing benefits locally but also nationally, regionally and even globally. At this time, tourism has become a livelihood for the community. The national tourism policy is handed down to the provincial, city-regency and local governments. Implementation and execution of the program must start from the predetermined destination site environment, namely tourism awareness for the community. Baluwarti Village, Baluwarti Sub-District, Pasar Kliwon District, Surakarta City, is an important part of the main destination supporting the international-standard Surakarta Kasunanan Palace. The level of tourism awareness that has not been understood needs to be socialized through the Sapta Pesona concept. Tourism actors are expected to be professional in handling visitors through guides, developing palace area destinations, fulfilling hospitality and synergizing between departments in tourism activities.
Improving Students' Vocabulary Mastery by Using Upin and Ipin Cartoon Movie at Seventh Grade Students of SMP Angkasa Mandai
Authors: Maliang Muhammad Iqbal 
Published: May 2023

Abstract
Cartoon movie are designed not only to entertain children, but cartoons can be also used to teach and educate the children. The objectives of the study that are to find out whether “Upin and Ipin” cartoon movie can improve the students’ vocabulary and to know whether there is an increase between pre test and post test about the types of vocabulary of "Upin and Ipin" cartoon movie. The method of the research used pre-experimental method with one group pre-test and post-test design. The pre-test administered in order to know students’ vocabulary achievement after. Conducted treatment by using upin and ipin cartoon movie episode 16 Spiritual Night. The subject of the study was seventh grade students of SMP Angkasa Mandai. There were 30 students. Based on finding and discussion, it can be seen that this research shows us that the using Upin and Ipin cartoon movie episode 16 Spritual Night can help students to improve understanding on vocabulary mastery about kinds of vocabulary. After two test was done, there is significant improvement of vocabulary by using Upin and Ipin cartoon movie episode 16 Spritual Night. Pre test mean score (49.67 %) and the post test mean score (88%). The role of media is very important to increasing achievement vocabulary mastery. Therefore, to help the students to remember vocabulary and practice in learning language. It is one of solution to be used as appropriate method in teaching learning process
Id, Ego and Superego in McCarthy's Novel The Road
Authors: Nazim Jamal Baraa , JaF Susan Raheem Rahman 
Published: May 2023

With his psychoanalytic theory, Sigmund Freud asserts that human behavior mostly occurs in the subconscious part of the brain. This theory leaves many questions for those interested in studying human behavior, as it leaves many questions for them. One of the most important of these questions is can a person really control his behavior? Freud's theory of the unconscious divides it into three drives: the id, the ego, and the superego. Ed is the most aggressive behavior in humans. The super ego is the part responsible for the moral aspect that pushes a person to do well. As for the ego, it is that part of the dengue that strives to find a middle ground between the id and the superego. Thus, the current study aims to identify the cause of corruption of human soul through analyzing the British novelist Cormac McCarthy’s The Road. It will illustrate the human struggle for survival under a circumstance in which the law collapses and the ethics that are the basis of human interaction for the permanence of life disappear. It also sheds light on how to solve this problem. It should be noted that the study is formatted in APA (8) writing style in discussing the study and documenting the primary and secondary resources.
Análise socioeconômica e de prevalência da mortalidade infantil por Meningite no Brasil ao longo de uma década
Authors: Falcão Ingrid Marcelle Lopes , Coelho Thyerre Castro , Maia Matheus da Silveira , Do Nascimento Bianca Rodrigues , De Sousa Lucas Aguiar , Vieira Gustavo Neves , Magalhães Átila Barros 
Published: May 2023

A doença conhecida como meningite é provocada pela inflamação das meninges que envolvem o sistema nervoso central, que inclui o cérebro e a medula espinhal. As taxas de mortalidade ainda permanecem altas, variando de 5 a 30% dos casos, e cerca de 50% dos sobreviventes desenvolvem sequelas neurológicas. Os efeitos mais comuns da meningite, variando na dependência do agente etiológico envolvido, em crianças que sobrevivem incluem perda auditiva, atrasos no desenvolvimento e baixo desempenho acadêmico. Neste contexto, objetivou-se na presente pesquisa avaliar o perfil epidemiológico dos casos de meningite infantil no Brasil, diagnosticados em crianças menores que 1 ano, no período de 2011 a 2020. A presente pesquisa foi realizada por meio de um estudo retrospectivo, quantitativo, com dados secundários temporais coletados da base de dados do DATASUS de acordo com o Sistema de Informação de Agravos de Notificação (SINAN). As variáveis avaliadas foram: Região do país, sexo, faixa etária, raça, peso ao nascer, idade gestacional e escolaridade da mãe. Os dados foram analisados por meio de estatística descritiva e foram representados na forma de gráficos. No Brasil entre o período de 2011 a 2020 foram diagnosticados 1.146 casos de meningite infantil (0 a 11 meses de vida). A região Sudeste apresentou o maior número de crianças e neonatos com meningite, e menor número na Centro-Oeste. O sexo masculino e das raças branca e parda foram os mais afetados pela doença. Ademais, peso ao nascer menor que 3 quilogramas, idade gestacional menor que 37 semanas e grau de escolaridade entre 8-11 anos de educação formal demonstraram maior prevalência.
Tuberculose extrapulmonar como causa de pericardite constritiva: um diagnóstico difícil que deve ser considerado
Authors: Amaral Eulem Cintia Sabino Oliveira , Nobre Marlucia do Nascimento , De Souza Andrio Portilho , Henriques Junior Jose Antonio Berlange , Corrêa Sâmia Amorim , Dantas Bruna Pinto 
Published: May 2023

Introdução: a tuberculose é causa de mortalidade por um único agente infeccioso, o mycobacterium tuberculosis, que afeta o sistema respiratório e outros sistemas do corpo humano, como o sistema cardiovascular. Ela pode acometer o pericárdio e levar à pericardite tuberculosa, que em sua apresentação típica se dá na forma de pericardite constritiva. Objetivo: relatar o caso de um paciente com pericardite constritiva secundária a uma tuberculose extrapulmonar. Caso clínico: paciente, sexo masculino, 17 anos, sintomas de tuberculose, mas exames não compatíveis, que desenvolveu hepatite medicamentosa com o uso dos antituberculínicos. Após biópsia do pericárdio foi constatada pericardite constritiva por tuberculose extrapulmonar. Foi realizada pericardiectomia em que se constatou mediastinite. Iniciou-se um esquema de antibioticoterapia alternativo devido à hepatite medicamentosa ao uso do esquema terapêutico inicial. O paciente evoluiu com boa resposta a esse esquema terapêutico, sem efeitos colaterais relatados. Conclusão: a pericardiectomia continua sendo o tratamento de escolha para pacientes com sintomas graves de pericardite constritiva causada por tuberculose pulmonar e/ou extrapulmonar. O paciente deste estudo repetiu o ecocardiograma e mostrou boa recuperação da função cardíaca.
New intersectional hybrids of Eupopulus L.
Authors: Tsarev Anatoliy , Tsareva Raisa , Tsarev Vadim , Myakotnikova Elena , Momot Raisa 
Published: May 2023

In world practice, there is an example of a sudden defeat of the best most productive poplar in Italy ‘I-214’ (‘Glory of Italy’), which in many European countries occupied up to 35% of poplar plantations. The defeat of leaf rust Marsonina brunnea for several years completely destroyed the plantings of this variety of poplar. This catastrophe led to
the formation of an approach that when creating plantings, it is necessary to use not one, even the best variety or clone, but several. There were proposals to plant at least 30-50 different clones, hybrids and varieties in close ecological conditions of the growing place. Such approaches began to spread not only in Western Europe, but also in other countries, including the Soviet Union and Russia. Reproduction of intersectional hybrids of poplars (Eupopulus L.) was carried out in production nurseries of the Voronezh and Lipetsk regions. Analysis of the results of hybridization of poplars (balsamic × black and black × balsamic) showed that the survival rate of hybrid seedlings in the Semiluk collection No. 1 was (85-100%). Their safety by the age of 21 has decreased to 45-74%. According to the results of long-term observations, the average biometric growth indicators in height and diameter increased from 5.9 to 14.0 cm and from 8.6 to 24.4 m, respectively. The results of studies of 16 new intersectional hybrids show that the trunk volumes at the age of 21 ranged from 0.151 to 0.753 m3. In the future, it is planned to submit three candidates for varieties to the State Commission for Variety Testing of the Russian Federation: ‘Versiya', ‘Stroyn’ and ‘Borey’.
PERBANDINGAN KOMPRES DINGIN DAN KOMPRES HANGAT TERHADAP PENURUNAN NYERI MENSTRUASI DI PONDOK PESANTREN KABUPATEN NGAWI
Authors: Nurrafi Willda , Wijayanti Wijayanti , Umarianti Tresia 
Published: May 2023

ABSTRAK
Latar Belakang: Nyeri menstruasi merupakan terjadi sebelum dan selama menstruasi yang dapat mengganggu aktivitas. Prevalensi dysmenorrhea di Indonesia sebesar 60-70% wanita. Menyebabkan ketidaknyamanan, mengganggu aktifitas sehari-hari, Penanganan nyeri menstruasi farmakologis dan non farmakologis. Tujuan: Untuk mengetahui perbandingan efektivitas kompres dingin dan kompres hangat terhadap penurunan nyeri menstruasi, Metode: Penelitian ini eksperimen semu. Sampel diambil dengan teknik purposive sampling dengan jumlah 52 santriwati. Pengumpulan data menggunakan lembar observasi NRS 0-10. Analisis data menggunakan Uji Wilcoxon dan Uji Mann Whitney. Hasil: Rata-rata nyeri menstruasi sebelum dan sesudah diberikan kompres dingin didapatkan adalah (4,3) menjadi (3,92). Sedangkan sebelum dan sesudah dilakukan kompres hangat diberikan adalah (3,69) menjadi (1,92). Selanjutnya di Uji Wilcoxon disimpulkan bahwa ada perbedaan antara sebelum dan sesudah dilakukan teknik kompres hangat dengan nilai Sig. (0,000) dan kompres dingin dengan nilai Sig.(0,003). Karena pada uji normalitas terdapat data yang tidak terdistribusi normal hasil uji perbedaan menggunakan Uji Mann Whitney dengan hasil (p = 0,000) maka ada perbedaan penurunan nyeri menstruasi dengan kompres hangat dan kompres dingin. Simpulan: kompres hangat lebih efektif dalam menurunkan nyeri menstruasi

Kata kunci : nyeri menstruasi, kompres hangat, dan kompres dingin
PENGETAHUAN DAN SIKAP MAHASISWA DENGAN PRA MENSTRUASI SINDROM
Authors: Angrainy Rizka , Istawati Rika , Putri Monifa 
Published: May 2023

Pre Menstrual Syndrome (PMS) is broadly defined as a recurring disorder around 67% of female students who experience premenstrual syndrome disorder is the most disturbing complaint that reduces the quality of learning by up to 50%, around 14% of women between the ages of 20 to 35 years, pre Menstrual syndrome can greatly affect the effect so that it requires them to rest, the premenstrual syndrome will disappear after menstruation is over and due to the lack of knowledge of respondents in understanding the signs and symptoms of premenstrual syndrome. This study aims to determine the relationship between the knowledge and attitudes of female students with premenstrual syndrome (PMS) to find out the signs and symptoms of premenstrual syndrome as early as possible. This type of research uses quantitative analytic methods, with a cross-sectional design, the total population from levels I, II, and III is 228 people, and a sample of 69 people is obtained by accidental sampling technique. Of the 69 respondents who showed good knowledge and did not experience premenstrual syndrome, 18 people (59.9%) were good and 16 (47.1%) experienced premenstrual syndrome. (50.2%) and experienced premenstrual syndrome in 24 people (50.2%). Based on the chi-square test, a p-value of 0.000 was obtained, which means that p <0.05 there is a relationship between female students' knowledge and premenstrual syndrome, p<0.032. There is a significant relationship between student attitudes and premenstrual syndrome.
HUBUNGAN STATUS MENYUSUI DENGAN PRODUKSI ASI
Authors: Noviawanti Rice 
Published: May 2023

Pemberian ASI direkomendasikan secara ekslusif 6 bulan dan dilanjutkan selama 2 tahun, banyaknya keuntungan dan maanfaat pemberian ASI masih ditunjukkan dengan cakupan pemberian ASI kurang dari 100% yaitu 69.7% ditahun 2021. Banyak hal yang menjadi faktor rendahnya cakupan ASI salah satunya kemampuan ibu dalam memproduksi ASI dengan baik. Penelitian ini bertujuan mengetahui hubungan status menyusui ibu dengan jumlah produksi ASI. Penelitian ini merupakan penelitian deskriptif kuantitatif analitik melalui pendekakan scrosectional dengan uji chi-squre yang diambil melalui data sekunder sebanyak 30 populasi dan sampel. Hasil uji didapatkan nilai p value (0.045) yang berarti terdapat hubungan bermakna antara status menyusui dengan produksi ASI.
GAMBARAN INTERVENSI PROGRAM HIV AIDS TERKAIT FAKTOR PENYEBAB KEGAGALAN PENGOBATAN ANTIRETROVIRAL PADA ODHA DI MAKASSAR
Authors: Akbar Alwi M. , Tenriawi Westy 
Published: May 2023

HIV/AIDS merupakan kondisi dimana sistem kekebalan tubuh menurun. Masalah ini dapat mengancam seluruh lapisan masyarakat. Salah satu upaya untuk penanganan orang dengan HIV/AIDS (ODHA) adalah dengag terapi ARV seumur hidup. Namun, para ODHA sangat berisiko untuk mengalami loss follow up dari terapi ini disebabkan oleh beberapa faktor . Tujuan penelitian ini adalah untuk mendeskripsikan faktor penyebab ODHA mengalami kegagalan dalam terapi ARV. Penelitian ini merupakan penelitian kualittaif dengan menggunakan snowball sampling dengan melibatkan 10 informan. Informan dalm penelitian ini yaitu : ODHA, konselor, tokoh masyarakat dan staff dinas kesehatan Makassar. Hasil penelitian ini menunjukkan bahwa semua informan mengetahui bahwa ARV merupakan terapi untuk penyembuhan. Sebagai ODHA, mereka mendapatkan dukungan dari keluarag seperti pasangan, anak, orang tua. Namun, hanya sebagian informan yang mendapat dukungan keluarga karena sebagian informan belum terbuka dengan status HIV mereka. Tenaga Kesehatan atau konselor ODHA sangat berperan aktif dalam penanganan terapi ARV dengan menjalin komunikasi yang aktif. Selain itu, tersedianya fasilitas yang cukup dan memadai di tempat terapi ARV. Kesimpulan penelitian ini yaitu pengetahuan menjadi penyebab gagal ARV ODHA di kota Makassar. Dukungan keluarga dan lingkungan pada ODHA cukup baik dimana banyaknya Informan yang merasa di perhatikan dan masih memiliki waktu bersama keluarga untuk melakukan terapi ARV. Terjalin hubungan yang baik dari segi komunikasi antara petugas dan ODHA serta tersedia fasilitas yang cukup di Puskesmas.
SIKAP IBU DALAM PENANGANAN DIARE PADA ANAK BALITA
Authors: Hermanita Yuni , Roza Adila Dian , Fitrina Lestari Raja , Utami Agnita 
Published: May 2023

Diare menjadi urutan kedelapan penyebab kematian terbesar bagi balita di dunia juga di Indonesia. Hal tersebut dikarenakan seriusnya dampak akibat diare yang terjadi, seperti adanya dehidrasi, malnutrisi, bahkan kematian, sehingga penanganan diare harus menjadi penentu keberhasilan pencegahan pertumbuhan kasus, penting bagi ibu dalam memberikan tanggung jawab dan perhatian terhadap balita dalam sikap penanganan diare. Tujuan ini penelitian ini mengetahui gambaran sikap ibu dalam penanganan diare pada anak balita di Puskesmas Harapan Raya. Metode penelitian adalah kuantitatif dengan desain deskriptif, pengambilan sampel menggunakan teknik purposive sampling terhadap 85 responden, dari jumlah populasi sebanyak 107 orang. Data diperoleh melalui penyebaran kuesioner skala likert dengan analisa univariat. Berdasarkan hasil penelitian didapatkan mayoritas responden memiliki sikap positif dalam penanganan diare sebanyak 46 orang (54,1%), namun dilihat dari karakteristik responden berdasarkan sikap mayoritas ibu dengan usia dewasa awal (21- 35 tahun) sebanyak 23 orang (27,1%) memiliki sikap negatif, mayoritas ibu berpendidikan tinggi Diploma hingga Sarjana sebanyak 37 orang (43,5%) memiliki sikap negatif, sedangkan pekerjaan IRT sebanyak 23 orang (27,1%) ibu bersikap positif dan negatif sama banyak. Alasan ibu memiliki sikap positif dikarenakan, Ibu sangat setuju penanganan diare pada balita untuk membawa ke pelayanan kesehatan seperti, Puskesmas dan Rumah Sakit, sedangkan ibu bersikap negatif dikarenakan, ibu sangat tidak setuju menghentikan pemberian makanan pada balita dan lebih banyak memberikan asupan air saja. Berdasarkan sikap yang digambarkan menandakan bahwasanya ibu harus lebih aktif untuk mencari informasi dalam memilih penanganan diare secara baik pada balita, dan pihak Puskesmas Harapan Raya dapat melakukan promosi kesehatan terkait penanganan diare pada balita.