bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carboxylate‐Directed Palladium‐Catalyzed Regioselective Mizoroki‐Heck Alkenylation of γ,δ‐Unsaturated Carboxylic Acids
Authors: Tsai Si‐Yu , Huang Yu‐Wen , Chou Chih‐Ming 
Published: February 2023

AbstractA carboxylate‐directed palladium‐catalyzed Mizoroki–Heck alkenylation of γ,δ‐unsaturated carboxylic acids with alkenyl bromides is reported. This carboxylate group is effective for chelation to a Pd center, enabling the distal alkenylation of electronically unbiased internal alkenes in the formation of conjugated 1,3‐dienes with high stereoselectivity. In addition, the conjugated 1,3‐diene products can be used for synthetic applications through reduction, epoxidation, methylation, amidation, and cycloaddition.magnified image
Yield protection afforded by imidacloprid during Hessian fly infestation in six genotypes
Authors: Winn Zachary J. , Reisig Dominic , Murphy Joseph P. 
Published: February 2023

AbstractThe Hessian fly (Mayetiola destructor Say) is a gall midge that infests and feeds upon wheat (Triticum aestivum L.). Recently, a new form of tolerance (QHft.nc‐7D) was identified in the breeding line LA03136E71 (PI 700336). Partial resistance allows immature Hessian fly to thrive in small numbers and does not function like antibiosis. Little is known about the potential yield drag of using partial resistance. In this study, we evaluated six genotypes: one containing QHft.nc‐7D (LA03136E71), one containing H13, and four potentially susceptible genotypes. All genotypes were evaluated with two different seed treatment regiments of imidacloprid: no treatment and a two times rate of imidacloprid. All tested genotypes were planted in six‐to‐eight replications of a full factorial design in four environments. Subsamples of yield trial plots were taken to measure percent infested tillers and a number of larvae/pupae per tiller. Plots were harvested and grain yield was recorded. There was a significant (p[>F] < 0.05) reduction of percent infested tillers and a number of larvae/pupae per tiller related to the imidacloprid treatment. Imidacloprid treatment significantly (p[>T] < 0.05) reduced the number of larvae/pupae per tiller for LA03136E71. There was no significant (p[>T] > 0.05) grain yield increase associated with treatment for LA03136E71. This indicates that a two times application of imidacloprid on LA03136E71 (QHft.nc‐7D) did not improve yield yet reduced infestation. Therefore, QHft.nc‐7D, while allowing Hessian fly to thrive on the plant, does not significantly compromise yield.
Postoperative complications and prognosis based on type of surgery in ulcerative colitis patients with colorectal cancer: A multicenter observational study of data from the Japanese Society for Cancer of the Colon and Rectum
Authors: Hoshino Nobuaki , Hida Koya , Yoshida Shinya , Ueno Kohei , Noguchi Tatsuki , Ishihara Soichiro , Sugihara Kenichi , Ajioka Yoichi , Obama Kazutaka 
Published: February 2023

AbstractBackgroundPatients with ulcerative colitis are reported to be at increased risk of colorectal cancer and are also at high risk of postoperative complications. However, the incidence of postoperative complications in these patients and how the type of surgery performed affects prognosis are not well understood.MethodsData collected by the Japanese Society for Cancer of the Colon and Rectum on ulcerative colitis patients with colorectal cancer between January 1983 and December 2020 were analyzed according to whether total colorectal resection was performed with ileoanal anastomosis (IAA), ileoanal canal anastomosis (IACA), or permanent stoma creation. The incidence of postoperative complications and the prognosis for each surgical technique were investigated.ResultsThe incidence of overall complications was not significantly different among the IAA, IACA, and stoma groups (32.7%, 32.3%, and 37.7%, respectively; p = 0.510). The incidence of infectious complications was significantly higher in the stoma group (21.2%) than in the IAA (12.9%) and IACA (14.6%) groups (p = 0.048); however, the noninfectious complication rate was lower in the stoma group (13.7%) than in the IAA (21.1%) and IACA (16.2%) groups (p = 0.088). Five‐year relapse‐free survival was higher in patients without complications than in those with complications in the IACA group (92.8% vs. 75.2%; p = 0.041) and the stoma group (78.1% vs. 71.2%, p = 0.333) but not in the IAA group (90.3% vs. 90.0%, p = 0.888).ConclusionThe risks of infectious and noninfectious complications differed according to the type of surgical technique used. Postoperative complications worsened prognosis.
Modification of Al2O3‐based catalyst by rare earth elements for steam reforming of methane
Authors: Zhang Jianan , Zhao Min , Yin Zhi‐wen , Hu Zhi‐yi , Liu Yanan , He Yufei , Li Dianqing 
Published: February 2023

AbstractModification of rare earth elements (Ln) often contributes to the improved performance in many applications compared with the monometallic catalysts, but the current research is only limited in the individual light rare earth elements. In this work, a series of Ln elements involving Gd, Sm, Nd, Pr, and La was added into monometallic Ni/Al2O3 system to focus how the microstructure of active Ni centers depended on the presence and contents of Ln, and thus improved the catalytic behavior in the steam reforming of methane. Enhanced catalytic behavior could be observed over Ln‐modified Ni catalysts, among which Ni‐Gd/Al2O3 was predicted to be more high‐efficient no matter supported on power or spherical Al2O3 catalysts. A combined investigation of XPS with STEM and TPR was carried out over the candidates to reveal the structure‐performance relationship. Furthermore, this was further applied to noble metal systems, realizing the benign universality of the modification strategy.
Clinical findings in 39 individuals with Bohring–Opitz syndrome from a global patient‐driven registry with implications for tumor surveillance and recurrence risk
Authors: Russell Bianca E. , Kianmahd Rebecca R. , Munster Chelsea , Yu Anna , Ahad Leena , Tan Wen‐Hann 
Published: February 2023

AbstractBohring–Opitz syndrome (BOS) is a rare genetic condition caused by pathogenic variants in ASXL1, which is a gene involved in chromatin regulation. BOS is characterized by severe intellectual disabilities, distinctive facial features, hypertrichosis, facial nevus simplex, severe myopia, a typical posture in infancy, variable anomalies, and feeding issues. Wilms tumor has also been reported in two individuals. We report survey data from the largest known cohort of individuals with BOS with 34 participants from the ASXL Patient‐Driven Registry and data on five additional individuals with notable findings. Important or novel findings include hepatoblastoma (n = 1), an additional individual with Wilms tumor, two families with a parent who is mosaic including a pair of siblings, birth weights within the normal range for the majority of participants, as well as presence of craniosynostosis and hernias. Data also include characterization of communication, motor skills, and care level including hospitalization frequency and surgical interventions. No phenotype–genotype correlation could be identified. The ASXL Registry is also presented as a crucial tool for furthering ASXL research and to support the ASXL community.
Time course of serum neuron‐specific enolase levels from infancy to early adulthood in a female patient with beta‐propeller protein‐associated neurodegeneration
Authors: Hirano Shodo , Suzuki Yasuhiro , Ikeda Tae , Okamoto Nobuhiko 
Published: February 2023

AbstractBeta‐propeller protein‐associated neurodegeneration (BPAN), a subgroup of neurodegeneration with brain iron accumulation, is typically characterized by non‐progressive global developmental delay and seizures in childhood, followed by progressive neurological decline with parkinsonism and dementia in adolescence or early adulthood. It is difficult to clinically identify a patient with BPAN in childhood. Recent studies reported that serum levels of neuron‐specific enolase (NSE) were elevated in children with BPAN. We reviewed the time course of serum NSE levels in a 21‐year‐old female patient genetically diagnosed (a de novo WDR45 variant c.268A > T) with BPAN, which was suspected based on prolonged elevation of serum NSE. There was an overall tendency for serum NSE levels to decrease in a stepwise fashion. The peak serum NSE level was observed during the first 2 years of age and then decreased rapidly in 1 year. High serum NSE levels persisted between 3 and 11 years of age. Subsequently, serum NSE levels decreased and plateaued after 13 years of age. There were tendencies for both blood AST and LDH levels to decrease over time in parallel with serum NSE levels. Serum NSE levels may be a diagnostic biomarker of BPAN in children but becomes of less value in identifying a patient with BPAN after childhood.
Improvement of NO adsorptive selectivity by the embedding of Rh in MOF‐177 as carrier
Authors: Hu Jie , Zhai Ying , Li Shengchen , Li Lei , Tang Fushun , Ruan Le , Zhang Zhe 
Published: February 2023

In this paper, MOF‐177 was embedded with Rh for the improvement of NO adsorptive selectivity at room temperature. The results showed that the experimental NO saturated adsorption capacity of MOF‐177 was very limited value of 1.35 mL·g−1 with a negligible selectivity, but the embedded 3 wt % Rh/MOF‐177 improved it to 16 mL·g−1 with higher maximal selectivity of NO to CO2 (352) and to O2 (600) under low partial pressure. In the simulated mixture gas, the adsorption capacity of NO atmosphere was about 9–18 times higher than that of O2 and CO2, and the adsorptive selectivity was up to near 18. The reductive Rh particles in MOF‐177 were basically nanometer‐sized higher dispersion state by great carrier function of MOF‐177. The pulse adsorption experiments verified that one reduced Rh0 adsorbed three NO molecules, indicating that the NO adsorption form in Rh/MOF‐177 should be a trinitro‐group (Rh (NO)3) adsorbed species in low pressure. This work firstly illustrated that the MOFs materials embedded with metal particle such as Rh can obviously improve NO adsorption selectivity and also provided a reference way for functionalized modification of MOFs materials to enhance the adsorptive separation performance of pollutant NO in flue gas.
Pure oxygen condition forced oxidation ignition process of underground coal gasification
Authors: Li Yulong , Liang Jie , Zhao Ze , Zhao Ge , Zang Zhifei 
Published: February 2023

AbstractUnderground coal gasification without shaft is a technology that uses directional drilling technology to gasify deeply buried coal. The technology first needs to ignite the coal seam during drilling, but as the depth of the coal seam (drilling) increases, it is very difficult to ignite the underground coal seam. In order to ignite the underground coal seam more safely and effectively, the forced oxidation ignition technology has been developed; that is, the coal seam is heated by hot oxygen, and the coal seam is rapidly oxidized and released to ignite the coal seam. Due to the complex confidential environment, it is challenging to ignite underground coal seams. To ignite the underground coal seams more safely and effectively, this paper used a self‐made reactor to simulate the forced convection heating of the bituminous coal under different oxygen flow rates with hot oxygen and used a Fourier transform infrared spectrometer flue gas analyzer to detect the outlet gas, used ATR‐FTIR spectrometer to analyze the solid residues in different areas, and recorded the time and maximum temperature of coal ignition under other processes. The results showed that low‐flow high‐temperature oxygen could quickly burn coal seams. When the oxygen flow rate was 2.5 m3/h, and the coal seam was ignited when heated to 130°C for 170 min. Through GC‐MS analysis of nine flammable components in the tar components under different processes, the content of short‐chain aliphatic hydrocarbons in the tar decreases, and the content of benzene series tends to increase. Through ATR‐FTIR analysis, the solid sample near the gas injection port contained fewer oxygen functional groups; the middle of the furnace body included the most oxygen functional groups; near the gas outlet contained more oxygen functional groups than the raw coal. CO2 would rise to 3% when coal was about to ignite.
Design, synthesis and performance of novel fluorescent polymer microspheres tracers based on aggregation induced emission
Authors: Zhou Wu , Liang Qingxiang , Wu Aibin , Shu Wenming , Yu Weichu 
Published: February 2023

AbstractIn this study, blue fluorescent polymer microspheres tracers are prepared by dispersion polymerization using aggregation induced emission monomers, styrene and sodium vinyl benzene sulfonate as raw materials. The properties of the microspheres are investigated by field emission scanning electron microscopy, fluorescence microscopy and fluorescence spectrum. The results show that N‐(4‐(4‐(1,2,2‐triphenylvinyl)phenoxy)butyl)acrylamide exhibits typical AIE properties in a mixture of water and tetrahydrofuran. The fluorescent polymer microspheres are smooth and monodisperse. Concentration‐dependent experiments indicate that the fluorescence intensity of the fluorescent polymer microspheres increases with the increasing of concentration. In addition, we explore the effects of temperature, pH, and some metal ions on the fluorescent polymer microspheres, and find that the fluorescence intensity is still good under these influencing conditions. We also investigate the stability of the polymer, the fluorescence intensity of the polymer hardly changed during the 30‐day monitoring period, indicating its good stability. Therefore, the above research results indicate that the fluorescent polymer microspheres can be used as potential oilfield tracers.
Ladies in armor: A micro‐computed tomographic study of skin calcification in European toads (genus Bufo)
Authors: Cvijanović Milena , Ajduković Maja , Arntzen Jan W. , Ivanović Ana , Vučić Tijana 
Published: February 2023

AbstractMicro‐computed tomography is a powerful tool toward the detailed reconstruction of internal and external morphology, in particular for ossified and other dense tissues. Here, we document and compare the level of calcification in the skin of the head and the parotoids (the external skin glands) in males and females of common and spined toads, Bufo bufo and B. spinosus. In some anurans, including Bufo species, a specific acellular calcified tissue layer within the dermis has been documented (the Eberth‐Katschenko, or EK‐layer). By a combination of micro‐computed tomography and classical histology, we detected additional calcium deposits located in the dermal layer stratum spongiosum, positioned above the EK‐layer. We showed that the level of calcification and the presence of additional calcium deposits are size and sex related, increasing in the order B. bufo males, B. spinosus males, B. bufo females to B. spinosus females. The last of these groups is the least variable. Bufo spinosus females have dense calcium deposits in the parotoids and the dorsal and ventral skin. Three‐dimensional volume renderings and cross‐sectional slices obtained by micro‐CT scanning indicate that this approach is a promising technique for further studies on bufonid skin anatomy and geographic variation in skin calcification.
Possible optical counterparts of ULXs in NGC 1672
Authors: Allak Sinan , Akyuz Aysun , Sonbas Eda , Dhuga Kalvir S. 
Published: February 2023

AbstractIn this study, we use archival data from Hubble Space Telescope (HST), Chandra, XMM‐Newton, and Swift‐XRT, to probe the nature of 9 (X1‐X9) candidate ultraluminous X‐ray sources (ULXs) in NGC 1672. Our study focuses on using the precise source positions obtained via improved astrometry based on Chandra and HST observations to search for and identify optical counterparts for these ULXs. Unique optical counterparts are identified for X2 and X6; two potential counterparts were determined for X1, X5, and X7 within the respective error radii while no optical counterparts were found for the remaining four sources. Based on spectral energy distributions, X‐ray, and optical temporal analyses, some evidences about the nature of X1 and X2 were obtained.
Die TR‐Instandhaltung und die Maßstabsfrage bei „Schäden/Mängeln“ in Altfällen
Authors: Motzke Gerd 
Published: February 2023

AbstractWiens/Raupach sowie Helm haben sich mit der TR‐Instandhaltung des Deutschen Instituts für Bautechnik, 2020, mit den neuen Inhalten und den bautechnischen Randbedingungen einschließlich deren Anwendung befasst [1]. Schießl‐Pecka/Strehlein haben das Instandsetzungsverfahren nach der TR‐Instandhaltung und diesbezüglich besonders das Instandsetzungsprinzip W in Verbindung mit dem Einsatz von Hydrophobierungen aus der Planersicht beschrieben [2]. Den genannten Darstellungen liegt grundsätzlich der Anwendungsfall zugrunde, dass ein in die Jahre gekommenes Stahlbetonbauwerk instandsetzungsbedürftig ist. Neben diesem Grundfall gibt es auch den Sachverhalt, dass ein bereits instand gesetztes Stahlbetonbauwerk erneuten Instandsetzungsbedarf aufweist und deshalb Maßnahmen zu ergreifen sind. Diese Altfälle – markiert durch die Bezeichnung „Schäden“ in Altfällen (Instandsetzungsschäden) – sind um einen Sonderfall zu erweitern, den charakterisiert, dass an einem instand gesetzten Stahlbetonbauwerk Instandsetzungsmängel in offener Gewährleistungsfrist auftreten und der Auftraggeber Sachmängelrechte geltend macht (Instandsetzung von Instandsetzungsmängeln in offener Gewährleistungsfrist, Instandsetzungsmängel). Neben einschlägige Technikregeln treten damit Rechtsregeln. Der Beitrag befasst sich mit den dabei auftretenden Technik‐ und Rechtsfragen, die auch den Anwendungsbereich der TR‐Instandhaltung berühren und insbesondere auf den Stellenwert der Leistungsbeschreibung in Leistungsverzeichnissen abheben.
Chasing long‐range evolutionary couplings in the AlphaFold era
Authors: Karamanos Theodoros K. 
Published: February 2023

AbstractCoevolution between protein residues is normally interpreted as direct contact. However, the evolutionary record of a protein sequence contains rich information that may include long‐range functional couplings, couplings that report on homo‐oligomeric states or even conformational changes. Due to the complexity of the sequence space and the lack of structural information on various members of a protein family, it has been difficult to effectively mine the additional information encoded in a multiple sequence alignment (MSA). Here, taking advantage of the recent release of the AlphaFold (AF) database we attempt to identify coevolutionary couplings that cannot be explained simply by spatial proximity. We propose a simple computational method that performs direct coupling analysis on a MSA and searches for couplings that are not satisfied in any of the AF models of members of the identified protein family. Application of this method on 2012 protein families suggests that ~12% of the total identified coevolving residue pairs are spatially distant and more likely to be disordered than their contacting counterparts. We expect that this analysis will help improve the quality of coevolutionary distance restraints used for structure determination and will be useful in identifying potentially functional/allosteric cross‐talk between distant residues.
A simple and sensitive LC–MS/MS method for the determination of polyphyllin VII in rat plasma and its application to pharmacokinetic study
Authors: Wang Hao , Han Han , Xu Ying , Yang Yishun 
Published: February 2023

AbstractPolyphyllin VII is an isoprene saponin extracted from Rhizoma paridis, and it can effectively suppress tumor initiation, growth, and metastasis. In this study, we aim to develop and validate an LC–MS/MS method for the quantification of polyphyllin VII in rat plasma using digoxin as the internal standard (IS). The plasma samples were precipitated with methanol, and the samples were separated on an ACQUITY BEH C18 column (2.1 × 50 mm, 1.7 μm). The mobile phase consisted of 0.1% formic acid solution and acetonitrile. The detection was performed in the multiple reactions monitoring mode, with the precursor‐to‐product transitions of m/z 1075.4 > 883.3 for polyphyllin VII and m/z 779.4 > 649.6 for the IS. The method showed excellent linearity over the concentration range of 0.5–1000 ng/ml, with a correlation coefficient of 0.9996 (r = 0.9996). The lower limit of quantification was 0.5 ng/ml. The inter‐ and intra‐day accuracy (relative error) ranged from −4.8 to 5.9%, and precision (relative standard deviation) was < 9.0%. The assay showed high extraction recovery, ranging from 90.6 to 95.6%. Polyphyllin VII was demonstrated to be stable under the storage conditions. The validated LC–MS/MS method was successfully applied to the pharmacokinetic study of polyphyllin VII in rats after oral, intraperitoneal, and intravenous administrations. The pharmacokinetic results indicated that polyphyllin VII showed low oral (5.86%) bioavailability and moderate (38.81%) intraperitoneal bioavailability.
A marginal process of the zygomatic bone predicts a lateral exit of the zygomaticotemporal nerve: An anatomical study with application to surgery around the midface
Authors: Siddiqui Humza Faisal , Konschake Marko , Ottone Nicolás E. , Olewnik Łukasz , Iwanaga Joe , Aysenne Aimee , Xu Lu , Tubbs R. Shane 
Published: February 2023

AbstractPrevious studies have not verified the contents of accessory foramina of the zygomatic bone on dry skulls and thus could not conclude whether they carried accessory zygomaticofacial nerve branches or branches or the entire trunk of the zygomaticotemporal nerve (ZTN). Therefore, the aim of the current study is to present findings from cadaveric dissections to clarify this relationship. Fifty, fresh frozen, adult cadaveric sides underwent dissection of the ZTN. When identified, these nerves were quantified and their relationship to the zygomatic bone further documented by dissecting through the bone following the course of the nerve from a superficial to deep perspective. Additionally, 100 dry, adult, human skulls were analyzed looking for lateral foramina on the zygomatic bone. On three cadaveric sides (6%), the ZTN was found to pierce the zygomatic bone deeply and exit its superficial lateral surface. For dry skull specimens, a lateral zygomaticotemporal foramen (ZTF) was identified on nine sides (4.5%). For both groups, the presence of a strong marginal process of the zygomatic bone was strongly correlated to a ZTF exiting the lateral surface of the zygomatic bone. Although relatively uncommon, the ZTN can pierce the lateral aspect of the zygomatic bone and thus can be located superficial to the cheek. Such findings should be borne in mind during surgical or other invasive procedures in this area in order to minimize iatrogenic injury to the ZTN.