bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic Analysis by 4D Label-free MS-PRM Provides Insight into the
Role and Regulatory Mechanisms of IL-25 in NK Cells
Authors: Feng Juan , Huang Luoyao , Yang Shuaipeng , Pan Jiasheng , Zhu Xiangxing , Tang Dongsheng 
Published: September 2023

Background:
NK cells play an important role in immune response, immune surveillance,
and metabolism regulation. Therefore, NK cells are involved in the occurrence and development
of various diseases, such as infectious diseases, cancer, obesity, and diabetes. IL-25 is a special
member of the IL-17 family with anti-inflammatory function. IL-25 can regulate inflammatory
response and metabolism via various immune cells; however, the role and regulatory mechanism of
IL-25 in NK cells are still unclear.

Method:
In this study, we investigate the role of IL-25 in NK-cell protein profile via 4D label-free
mass spectrum and validate the differential proteins via PRM analysis. In addition, GO analysis,
KEGG analysis, and other bioinformatic analysis methods are used to explore the enriched function
and signal pathway of differentially expressed proteins.

Result and Discussion:
The GO and KEGG analyses suggest that IL-25 may affect the processes,
such as metabolism, thermogenesis, and oxidative phosphorylation of NK cells. There are 7 downregulated
proteins (NCR1, GZMB, PRF1, KLRC1, NDUFA11, LAMTOR5, and IKBIP) and 1 up-
-regulated protein (PSMD7) in IL-25-treated NK cells versus the control group for PRM validation.
Our results indicate that IL-25 may regulate metabolism and other biological processes via
NK cells, which will be beneficial in revealing the role and regulatory mechanisms of IL-25 in NK
cells in various diseases.

Conclusion:
Proteomics combined with bioinformatic analysis will help to mine more information
hidden behind mass spectrometry data and lay the foundation for finding clinical biomarkers and
mechanisms of diseases.
A Review on Graphene Analytical Sensors for Biomarker-based
Detection of Cancer
Authors: Gopinath Subash Chandra Bose , Ramanathan Santheraleka , More Mahesh , Patil Ketan , Patil Sharangouda Jagadevappa , Patil Narendra , Mahajan Mahendra , Madhavi Vemula 
Published: September 2023

Abstract:
The engineering of nanoscale materials has broadened the scope of nanotechnology
in a restricted functional system. Today, significant priority is given to immediate
health diagnosis and monitoring tools for point-of-care testing and patient care.
Graphene, as a one-atom carbon compound, has the potential to detect cancer biomarkers
and its derivatives. The atom-wide graphene layer specialises in physicochemical characteristics,
such as improved electrical and thermal conductivity, optical transparency, and
increased chemical and mechanical strength, thus making it the best material for cancer
biomarker detection. The outstanding mechanical, electrical, electrochemical, and optical
properties of two-dimensional graphene can fulfil the scientific goal of any biosensor development,
which is to develop a more compact and portable point-of-care device for
quick and early cancer diagnosis. The bio-functionalisation of recognised biomarkers can
be improved by oxygenated graphene layers and their composites. The significance of
graphene that gleans its missing data for its high expertise to be evaluated, including the
variety in surface modification and analytical reports. This review provides critical insights
into graphene to inspire research that would address the current and remaining hurdles
in cancer diagnosis.
Postbiotic as Novel Alternative Agent or Adjuvant for the Common
Antibiotic Utilized in the Food Industry
Authors: Sepordeh Sama , Jafari Amir Mohammad , Bazzaz Sara , Abbasi Amin , Aslani Ramin , Houshmandi Sousan , Rad Aziz Homayouni 
Published: September 2023

Background:
Antibiotic resistance is a serious public health problem as it causes previously manageable diseases to become deadly infections that can cause serious disability or even death. Scientists are creating novel approaches and procedures that are essential for the treatment of infections and limiting the improper use of antibiotics in an effort to counter this rising risk.

Objective:
With a focus on the numerous postbiotic metabolites formed from the beneficial gut microorganisms, their potential antimicrobial actions, and recent associated advancements in the food and medical areas, this review presents an overview of the emerging ways to prevent antibiotic resistance.

Results:
Presently, scientific literature confirms that plant-derived antimicrobials, RNA therapy, fecal microbiota transplantation, vaccines, nanoantibiotics, haemofiltration, predatory bacteria, immunotherapeutics, quorum-sensing inhibitors, phage therapies, and probiotics can be considered natural and efficient antibiotic alternative candidates. The investigations on appropriate probiotic strains have led to the characterization of specific metabolic byproducts of probiotics named postbiotics. Based on preclinical and clinical studies, postbiotics with their unique characteristics in terms of clinical (safe origin, without the potential spread of antibiotic resistance genes, unique and multiple antimicrobial action mechanisms), technological (stability and feasibility of large-scale production), and economic (low production costs) aspects can be used as a novel alternative agent or adjuvant for the common antibiotics utilized in the production of animal-based foods.

Conclusion:
Postbiotic constituents may be a new approach for utilization in the pharmaceutical and food sectors for developing therapeutic treatments. Further metabolomics investigations are required to describe novel postbiotics and clinical trials are also required to define the sufficient dose and optimum administration frequency of postbiotics.
Pathways from the Superior Colliculus to the Basal Ganglia
Authors: Melleu Fernando Falkenburger , Canteras Newton Sabino 
Published: September 2023

Abstract:
The present work aims to review the structural organization of the mammalian superior colliculus
(SC), the putative pathways connecting the SC and the basal ganglia, and their role in organizing
complex behavioral output. First, we review how the complex intrinsic connections between the
SC’s laminae projections allow for the construction of spatially aligned, visual-multisensory maps of
the surrounding environment. Moreover, we present a summary of the sensory-motor inputs of the SC,
including a description of the integration of multi-sensory inputs relevant to behavioral control. We
further examine the major descending outputs toward the brainstem and spinal cord. As the central
piece of this review, we provide a thorough analysis covering the putative interactions between the SC
and the basal ganglia. To this end, we explore the diverse thalamic routes by which information from
the SC may reach the striatum, including the pathways through the lateral posterior, parafascicular,
and rostral intralaminar thalamic nuclei. We also examine the interactions between the SC and subthalamic
nucleus, representing an additional pathway for the tectal modulation of the basal ganglia.
Moreover, we discuss how information from the SC might also be relayed to the basal ganglia through
midbrain tectonigral and tectotegmental projections directed at the substantia nigra compacta and ventrotegmental
area, respectively, influencing the dopaminergic outflow to the dorsal and ventral striatum.
We highlight the vast interplay between the SC and the basal ganglia and raise several missing
points that warrant being addressed in future studies.
Striatal Acetylcholine and Dopamine Interactions Produce Situationappropriate
Action Selection
Authors: Bradfield Laura A. , Becchi Serena , Kendig Michael D. 
Published: September 2023

Abstract:
Individuals often learn how to perform new actions for particular outcomes against a complex background of existing action-outcome associations. As such, this new knowledge can interfere or even compete with existing knowledge, such that individuals must use internal and external cues to determine which action is appropriate to the current situation. The question thus remains as to how this problem is solved at a neural level. Research over the last decade or so has begun to determine how the brain achieves situation-appropriate action selection. Several converging lines of evidence suggest that it is achieved through the complex interactions of acetylcholine and dopamine within the striatum in a manner that relies on glutamatergic inputs from the cortex and thalamus. Here we briefly review this evidence, then relate it to several very recent findings to provide new, speculative insights regarding the precise nature of striatal acetylcholine/dopamine interaction dynamics and their relation to situation-appropriate action selection.
Discovering Drug Candidates for Charcot Marie Tooth Disease Type-2
Authors: Shah Fahad Hassan , Eom Young Seok , Kim Song Ja 
Published: September 2023

Introduction:
Charcot Marie Tooth Disease-2 is a debilitating neurogenetic disorder that adversely
affects peripheral neurons by disrupting mitochondrial activity. Mutated mitofusin-2 (MFN) is the
main culprit behind disruptive mitochondrial function and is considered a therapeutic target in identifying
drugs for treating this disease. This disease has no therapeutic medication except for supportive care.

Objective:
The objective of the current study is to evaluate high-affinity medicinal compounds for mutated
MFN-2 and describe their absorption, distribution, metabolism, excretion, and toxic attributes
(ADMET).

Methods:
For ADMET properties, 2,219 medicinal compounds were analyzed with AutoDock Vina using
PyRX 0.9 software against MFN-2, SwissADME, and GUSAR.

Results:
Results from screening studies revealed that three compounds (Liriodenine, Pinocembrin, and
Vestitol) show an affinity for amino acids present in the predicted active interface of the MFN-2 protein.
Moreover, these compounds render low toxicity and efficient ADME qualities, combined with bloodbrain
barrier permeability, drug-likeness, and lead-likeness.

Conclusion:
Liriodenine, pinocembrin and vestitol are therapeutic compounds for CMT-2 treatment and
should be used in further in-vitro studies to confirm the results of this research.
Bdellovibrio bacteriovorus Therapy, an Emerging Alternative to Antibiotics
Authors: Abulude Ibukun J. , Kadouri Daniel E. , Guo Xianwu 
Published: September 2023

:
The increase in multi-drug resistant (MDR) pathogens and the decline in the number of new
antibiotics in the production pipeline pose a serious threat to our ability to treat infectious diseases. In this
new landscape, once treatable diseases are now potentially life-threatening. This impending danger requires
that urgent attention should be given to developing alternative strategies for combating MDR bacteria.
A novel alternative is the use of predatory bacteria, B. bacteriovorus spp, that naturally prey on
Gram-negative bacteria, including MDR Enterobacteriaceae. B. bacteriovorus has been shown to be nonpathogenic
in animal models and on human cell lines, supporting its feasibility to be used to treat infections
in animals and possibly humans. This document reviews various aspects of B. bacteriovorus biology,
including its unique life cycle, "predatory toolbox", prey range, and recent research advances exploring
B. bacteriovorus as an antimicrobial agent, stepping towards its use in human therapy. We also discuss
the advantages and limitations of using B. bacteriovorus therapy and the strategies to overcome these
limitations.
Drug-target Interaction Prediction By Combining Transformer and Graph
Neural Networks
Authors: Liu Junkai , Lu Yaoyao , Guan Shixuan , Jiang Tengsheng , Ding Yijie , Fu Qiming , Cui Zhiming , Wu Hongjie 
Published: September 2023

Background:
The prediction of drug-target interactions (DTIs) plays an essential role in
drug discovery. Recently, deep learning methods have been widely applied in DTI prediction. However,
most of the existing research does not fully utilize the molecular structures of drug compounds and
the sequence structures of proteins, which makes these models unable to obtain precise and effective
feature representations.

Methods:
In this study, we propose a novel deep learning framework combining transformer and graph
neural networks for predicting DTIs. Our model utilizes graph convolutional neural networks to capture
the global and local structure information of drugs, and convolutional neural networks are employed
to capture the sequence feature of targets. In addition, the obtained drug and protein representations
are input to multi-layer transformer encoders, respectively, to integrate their features and generate
final representations.

Results:
The experiments on benchmark datasets demonstrated that our model outperforms previous
graph-based and transformer-based methods, with 1.5% and 1.8% improvement in precision and 0.2%
and 1.0% improvement in recall, respectively. The results indicate that the transformer encoders effectively
extract feature information of both drug compounds and proteins.

Conclusion:
Overall, our proposed method validates the applicability of combining graph neural networks
and transformer architecture in drug discovery, and due to the attention mechanisms, it can extract
deep structure feature data of drugs and proteins.
Role of BDNF Signaling in the Neuroprotective and Memory-enhancing
Effects of Flavonoids in Alzheimer’s Disease
Authors: Amidfar Meysam , Garcez Michelle Lima , Askari Gholamreza , Bagherniya Mohammad , Khorvash Fariborz , Golpour-Hamedani Sahar , de Oliveira Jade 
Published: September 2023

Background::
Foods rich in flavonoids are associated with a reduced risk of various chronic
diseases, including Alzheimer's disease (AD). In fact, growing evidence suggests that consuming flavonoid-
rich foods can beneficially affect normal cognitive function. Animal models have shown that
many flavonoids prevent the development of AD-like pathology and improve cognitive deficits.

Objective::
Identifying the molecular causes underlying the memory-enhancing effect of flavonoid-rich
foods makes it possible to provide the best diet to prevent cognitive decline associated with aging and
Alzheimer's disease. Based on the most recent scientific literature, this review article critically examines
the therapeutic role of dietary flavonoids in ameliorating and preventing the progression of AD
and enhancement of memory with a focus on the role of the BDNF signaling pathway.

Methods::
The databases of PubMed, Web of Science, Google Scholar, and Scopus were searched up to
March 2023 and limited to English language. Search strategies were using the following keywords in
titles and abstracts: (Flavonoid-rich foods OR Flavonoids OR Polyphenols); AND (Brain-Derived Neurotrophic
Factor OR BDNF OR CREB OR) AND (Alzheimer's disease OR memory OR cognition OR).

Results::
Flavonoid-rich foods including green tea, berries, curcumin and pomegranate exert their beneficial
effects on memory decline associated with aging and Alzheimer's disease mostly through the
direct interaction with BDNF signaling pathway.

Conclusion::
The neuroprotective effects of flavonoid-rich foods through the CREB-BDNF mechanism
have the potential to prevent or limit memory decline due to aging and Alzheimer's disease, so
their consumption throughout life may prevent age-related cognitive impairment.
Interleukin-38 and Insulin Resistance
Authors: Klejbuk Kamil , Strączkowski Marek 
Published: September 2023

Abstract:
Insulin resistance, i.e., decreased biological response to insulin, is a risk factor for
many diseases, such as obesity, type 2 diabetes (T2DM), cardiovascular disease, polycystic ovary
syndrome, some forms of cancer and neurodegenerative diseases. One of its main causes is
chronic low-grade inflammation, mediated by the proinflammatory pathways, such as the c-Jun
N-terminal kinase (JNK) pathway and the nuclear factor kappa B (NFκB) pathway. Interleukin
(IL)-38 (IL-38) is a newly discovered cytokine that belongs to the IL-1 family. There are three
hypothetical pathways through which IL-38 may bind to the specific receptors and inhibit their
proinflammatory activity. Those pathways are associated with IL-36 receptor (IL-36R), IL-1 receptor
accessory protein-like 1 (IL1RAPL1) and IL-1 receptor 1 (IL1R1). There are studies linking
IL-38 to improve insulin sensitivity through the difference in serum IL-38 in patients with insulin
resistance or the correlation of IL-38 concentrations with insulin resistance indexes. However,
many questions still remain regarding the biological activity of IL-38 itself and its role in
the pathogenesis of insulin resistance. The goal of this study is to showcase IL-38, its biological
activity, hypothesized signaling pathways, connection with insulin resistance and future perspectives
of research on IL-38. We present that IL-38 associated signaling can be a potential target
for the treatment of insulin resistance and associated diseases.
Bearing Capacity of Skirted Ring Footing on Dense Sand Overlying Loose Sand
Authors: Dutta Rakesh Kumar , Priyanka Choudhary B. 
Published: September 2023

Introduction:
The ultimate bearing capacity of an unskirted/skirted ring foundation on dense sand overlying loose sand is estimated using finite element analysis in this study.

Methods:
The range of thickness ratio (thickness of top dense sand layer divided by external diameter of ring) was kept between 0.25 and 1.5. The friction angle of the upper dense and bottom loose sand layers was maintained between 40° and 44° and 30° and 34°, respectively. In the case of skirted ring footing, the skirts are attached at the inner edge, outer edge, and both the edges, respectively.

Results:
According to the results, the bearing capacity increases with an increase in either the friction angle of upper dense and lower loose sand layers or the thickness ratio. A double-skirted ring footing was observed to provide the greatest bearing capacity, followed by footing with skirts attached at the outer and inner edges, respectively.

Conclusion:
To sum up, the bearing capacity of the ring footing was higher than the circular footing for the given friction angle of the top and bottom layer and thickness ratio.
Pharmaceutical/Biomedical Applications of Electrospun Nanofibers -
Comprehensive Review, Attentive to Process Parameters and Patent
Landscape
Authors: Ramesh Varshini Hemmanahalli , Goudanavar Prakash , Ramesh Bevenahalli , Naveen Nimbagal Raghavendra , Gowthami Buduru 
Published: September 2023

:
Nanotechnology is a new science and business endeavour with worldwide economic benefits.
Growing knowledge of nanomaterial fabrication techniques has increased the focus on nanomaterial
preparation for various purposes. Nanofibers are one-dimensional nanomaterials having distinct physicochemical
properties and characteristics. Nanofibers are nanomaterial types with a cross-sectional dimension
of tens to hundreds of nanometres. They may create high porosity mesh networks with significant
interconnections among pores, making them suitable for advanced applications. Electrospinning
stands out for its ease of use, flexibility, low cost, and variety among the approaches described in the
literature. The most common method for making nanofibers is electrospinning. This article extensively
describes and summarizes the impact of various process variables on the fabrication of nanofibers. Special
attention has been given to scientific and patent prospection to confirm the research interests in
nanofibers.
SPECIFICS OF TEACHING FOREIGN LANGUAGES FOR THE MILITARY: ANALYSIS WITHIN THE ARMED FORCES ACADEMY IN SLOVAKIA
Authors: Révayová Eva 
Published: September 2023

Language skills have always represented an integral part of the key military competencies. In order to modernize and enhance the foreign language education of future officers, a research project has been carried out and selected aspects of this project have been shared in this paper. It is based on the theoretical and empirical knowledge of foreign language education at the Armed Forces Academy of gen. M. R. Štefánik in Slovakia and the transition from on-site learning to e-learning with particular focus on multimodality in foreign language education.
Culturas libres
Authors: Orozco Marín Angela María , Yáñez Canal Carlos , López Saldarriaga Leidy Tatiana , Bustamante Lozano Uriel 
Published: September 2023

El presente texto es resultado de un proceso investigativo que ha buscado aproximarse a la conformación de las organizaciones de cultura libre en Colombia, a través de la gestión de los procesos culturales y la indagación de las dimensiones administrativas, de carácter estratégico y orientador de las organizaciones del sector cultural y creativo. La metodología partió de un estudio de caso, con enfoque cualitativo, desarrollado en cuatro fases: exploratoria, descriptiva, analítica y de resultados, llegando a determinar tres formas de organización emergentes de la implementación de los principios de la cultura libre: horizontal, en ondas y en red.
Educando com mel e dendê
Authors: Monteiro Elaine , Ferreira dos Reis Paula 
Published: September 2023

Este artigo é resultado da pesquisa de trabalho de conclusão de curso de Licenciatura em Pedagogia. Buscou investigar o terreiro como um espaço de educação e como um lugar que produz uma narrativa da história do povo preto no Brasil, identificando como ocorreu na diáspora africana a resistência à escravidão e à dominação no Candomblé, assim como processos de transmissão de saberes e de afirmação da identidade negra. Se fundamenta e justifica no estudo do racismo estrutural, em sua relação com a escola e com o currículo e em suas implicações e consequências na subjetividade de pessoas negras, em especial as crianças. Apresenta o terreiro de candomblé como espaço de educação, de cultura, de fortalecimento e afirmação da identidade de pessoas negras. Os referenciais teórico-metodológicos da pesquisa tomam por base os conceitos de encruzilhada, de rodopio, de pesquisador-cambono, assim como os de oralidade e oralitura especialmente para tratar a entrevista realizada com Mãe Rosiane Rodrigues de Yemanjá. A partir da entrevista e do diálogo que nela se estabelece, emergem questões como ancestralidade, educação nos terreiros, infância, racismo, problemas enfrentados pelas crianças do candomblé na escola e relação entre o candomblé e a vida.
Palavras-Chave: educação nos terreiros de candomblé; infâncias; racismo religioso; racismo na escola.
Encontro de Saberes
Authors: Vianna Letícia C. R. 
Published: September 2023

Este artigo traz uma atualização do estado da arte do movimento Encontro de Saberes – um movimento de descolonização e contracolonização, visando a pluralidade epistêmica no ambiente da universidade brasileira, através da inclusão de mestras e mestres dos saberes tradicionais populares, oriundos de sociedades indígenas, comunidades de terreiro, quilombolas, agroextrativistas, grupos urbanos de diferentes culturas e demais povos tradicionais para atuarem como docentes e pesquisadores nas universidades. Por um lado, observa-se o estado da arte do Encontro de Saberes enquanto movimento de inclusão epistêmica e inovação curricular, complementar e integrado à política de inclusão étnico-racial por meio de cotas na discência, docência, pesquisa e administração da universidade. Por outro lado, observa-se este movimento integrado ao espírito do tempo de processo revolucionário à luz da teoria da revolução de Álvaro Garcia Linera.