bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERAN BUDAYA LOKAL DALAM ADOPSI INOVASI PADA MASYARAKAT SUKU TENGGER
Authors: Romadi Ugik , Yastutik Yastutik 
Published: August 2023

Penelitian ini bertujuan untuk mengkaji peran budaya lokal masyarakay suku tengger pada proses adopsi inovasi diera new normal. Penelitian ini menggunakan pendekatan kualitatif dengan metode fenomenologi. Informan dalam penelitian ini adalah Penyuluh Pertanian, Mantri Tani, Tokoh Masyarakat/Ketua Adat dan Petani Kecamata Tosari Kabupaten Pasuruan Berdasarkan hasil kajian diketahui bahwa pada masyarakat suku tengger memiliki budaya lokal yang dapat menentukan cepat atau lambatnya suatu proses adopsi inovasi, sebagai masyarakat yang mayoritas adalah petani sayuran, maka perlu adanya suatu inovasi dalam proses berbudidaya, sebagai upaya untuk dapat meningkatkan kesejahteraan para petani. Diterima atau tidaknya suatu inovasi sangat ditentukan oleh kebudayaan yang dimiliki, selama inovsi yang akan diterima tidak bertentengan dengan budaya yang mereka anut secara turun temurun. Pada kondisi ini strategi dan pendekatan oleh agen pembaharu terutama diera new normal seperti ini harus cermat dan tepat, agar peroses penyampaian inovasi dapat di adopsi oleh petani di wilayah Tengger.
Kata Kunci: budaya lokal, adopsi inovasi, suku Tengger
Penyimpangan Prinsip Kerja Sama dan Prinsip Kesopanan dalam Wacana Humor Cangehgar Radio Rama FM Bandung
Authors: Aziz Abdul , Gintings Mohammad Fajar Mediyawan 
Published: August 2023

Penelitian ini bertujuan untuk mendeskripsian pelanggaran prinsip kerjasama dan prinsip kesopanan dalam wacana humor Sunda Cangehgar di Radio Rama FM Bandung. Penelitian ini menggunakan metode deskriptif kualitatif dan teori pragmatic. Dari penggunaan metode dan teori tersebut dihasilkan Cangehgar sepenuhnya menggunakan pelanggaran terhadap prinsip kerjasama yang meliputi pelanggaran terhadap maksim kuantitas, maksim kualitas, maksim cara dan maksim hubungan. Selain itu prinsip kesopanan yang dilanggar juga meliputi maksim kearifan, maksim kebijaksanaan, maksim pujian, maksim kerendahan hati dan maksim simpati. Pelanggaran terhadap prinsip yang digariskan oleh Grice dan Leech tersebut dimunculkan untuk memberikan efek kejenakaan dan kelucuan.
Kata Kunci: prinsip kerjasama, prinsip kesopanan, Cangehgar
RANCANG BANGUN SISTEM INFORMASI PENGELOLAAN MATERIAL SPRAY PAINTING DI PT WOHLRAB INDONESIA
Authors: Tumanggor Ferinando , Silalahi Mesri 
Published: August 2023

PT Wohlrab Indonesia has indeed managed materials well. But in its implementation it takes time, energy, and money. This is because doing inventory calculations takes a long time, because it has to be written down on paper and then inputted in Ms. Excel and stored in the file folder. It also requires writing utensils, paper and other equipment. When viewed from a cost perspective, this process requires quite a lot of money because you have to pay for various writing equipment and others, including employee salaries. The research method used is observation, interviews, analysis, conclusion drawing and then the design method used is the SDLC (System Development Life Cycle) method with the Waterfall model. The purpose of this research is to design a Spray Painting Material Management Information System at PT Wohlrab Indonesia and also to build a spray painting material management information system at PT Wohlrab Indonesia. The results of this study are the need for a spray painting material management system at PT Wohlrab Indonesia, it can be concluded that PT Wohlrab Indonesia's spray painting material management information system is designed to provide convenience to admins in managing spray painting material because it is designed with an easy-to-understand or user friendly interface. can also process data quickly and accurately. PT Wohlrab Indonesia's spray painting material management information system uses web-based programming, developed using the PHP programming language and MySQL database. This system can improve admin performance in managing material data and can reduce errors in making reports, loss of material data because data stored in the database cannot be manipulated by parties who do not have access, even conducting data searches can be done quickly and accurately.
Keywords : Information; Management; Materials; Systems.
Delayed acquisition of airway commensals in antibiotic naïve children and its relationship with wheezing in rural Ecuador
Authors: Cardenas Paul A. , Cox Michael J. , Willis-Owen Saffron A. , Moffatt Miriam F. , Cookson William O. , Cooper Philip J. 
Published: August 2023

IntroductionThe hygiene hypothesis identified a relationship between living in rural areas and acquiring protective environmental factors against the development of asthma and atopy. In our previous study, we found a correlation between particular bacterial species and early-onset wheezing in infants from the rural tropics of Ecuador who were corticosteroid-naïve and had limited antibiotic exposure. We now describe a longitudinal study of infants conducted to determine the age-related changes of the microbiome and its relationship with wheezing.MethodsWe performed an amplicon sequencing of the 16S rRNA bacterial gene from the oropharyngeal samples obtained from 110 infants who had a history of recurrent episodic wheezing sampled at different ages (7, 12, and 24 months) and compared it to the sequencing of the oropharyngeal samples from 150 healthy infants sampled at the same time points. Bioinformatic analyses were conducted using QIIME and R.ResultsAs expected, the microbiota diversity consistently increased as the infants grew older. Considering age-based microbiota changes, we found that infants with wheeze had significantly lower species richness than the healthy infants at 7 months, but not at 12 or 24 months. Most of the core and accessory organisms increased in abundance and prevalence with age, except for a few which decreased. At 7 months of age, infants with wheeze had notably higher levels of a single Streptococcus operational taxonomic unit and core microbiota member than controls.ConclusionsIn a cohort with limited antibiotic and corticosteroid use, a progressively more complex and diverse respiratory microbial community develops with age. The respiratory microbiota in early life is altered in infants with wheeze, but this does not hold true in older infants.
Development of tetracycline-modified nanoparticles for bone-targeted delivery of anti-tubercular drug
Authors: Liang Qiuzhen , Zhang Pengfei , Zhang Liang , Luan Haopeng , Li Xinxia , Xiang Haibin , Jing Shuang , Song Xinghua 
Published: August 2023

Background: Since the poor response to existing anti-tuberculosis drugs and low drug concentration in local bone tissues, the traditional drug therapy does not result in satisfactory treatment of osteoarticular tuberculosis. Thus, we report a rifapentine release system with imparted bone targeting potential using tetracycline (TC) -modified nanoparticles (NPs).Methods: TC was conjugated to PLGA-PEG copolymer via a DCC/NHS technique. Rifapentine-loaded NPs were prepared by premix membrane emulsification technique. The resulting NPs were characterized in terms of physicochemical characterization, hemolytic study, cytotoxicity, bone mineral binding ability, in vitro drug release, stability test and antitubercular activity. The pharmacokinetic and biodistribution studies were also performed in mice.Results: Rifapentine loaded TC-PLGA-PEG NPs were proved to be 48.8 nm in size with encapsulation efficiency and drug loading of 83.3% ± 5.5% and 8.1% ± 0.4%, respectively. The release of rifapentine from NPs could be maintained for more than 60 h. Most (68.0%) TC-PLGA-PEG NPs could bind to HAp powder in vitro. The cellular studies revealed that NPs were safe for intravenous administration. In vivo evaluations also revealed that the drug concentration of bone tissue in TC–PLGA–PEG group was significantly higher than that in other groups at all time (p &lt; 0.05). Both NPs could improve pharmacokinetic parameters without evident organ toxicity. The minimal inhibitory concentration of NPs was 0.094 μg/mL, whereas this of free rifapentine was 0.25 μg/mL.Conclusion: Rifapentine loaded TC-PLGA-PEG NPs could increase the amount of rifapentine in bone tissue, prolong drug release in systemic circulation, enhance anti-tuberculosis activity, and thereby reducing dose and frequency of drug therapy for osteoarticular tuberculosis.
Synthesis of a novel Cu/DPA-MOF/OP/CS hydrogel with high capability in antimicrobial studies
Authors: Jasim Al-Khafaji Hanadi Hadi , Alsalamy Ali , Abed Jawad Mohammed , Ali Nasser Hind , Dawood Ashour H. , Hasan Saif Yaseen , Ahmad Irfan , Gatea M. Abdulfadhil , Younis Albahadly Waleed Khaled 
Published: August 2023

Today, with the indiscriminate use of antibiotics, we face the resistance of some bacterial strains against some antibiotics. Therefore, it is essential to report and synthesize new compounds with antimicrobial properties. A novel copper/dipicolinic acid–metal–organic framework cross-linked oxidized pectin and chitosan (Cu/DPA-MOF/OP/CS) hydrogel polymer was synthesized under environmental conditions with the controllable process, which uses biodegradable polymer compounds such as pectin and chitosan in its structure. The efficient physicochemical features of the synthesized Cu/DPA-MOF/OP/CS hydrogel using SEM, FT-IR, TGA, BET, XRD, and EDS/mapping were identified and confirmed. The newly synthesized Cu/DPA-MOF/OP/CS hydrogel showed activity against Gram-positive and Gram-negative bacterial strains and fungal species, and significant antibacterial and antifungal properties were observed. In antibacterial activity, the MIC against Gram-positive species was in the range of 16–128 mg/mL, the MIC against Gram-negative species was in the range of 64–256 mg/mL, and the MIC against fungal species was in the range of 128–512 mg/mL. In antimicrobial evaluations, in addition to the MIC test, the MBC test, the MFC test, and the IZD test were performed, and the results were reported. The results were compared with commercial antibiotics in the market. Development of novel nanostructures based on hydrogel polymers with distinctive functionality can affect the performance of these nanostructures in different areas.
Analysis of heterogeneity of the different health technology assessment reports produced on the transcatheter aortic valve implantation in patients with severe aortic valve stenosis at low surgical risk
Authors: Rumi Filippo , Fortunato Agostino , Antonini Debora , Siviero Ludovica , Cicchetti Americo 
Published: August 2023

BackgroundSymptomatic severe aortic stenosis is a congenital or acquired aortic valve disease that occurs when the aortic valve of the heart narrows. It represents the most common valvular disease in adults and generally has a degenerative nature. Transcatheter aortic valve implantation (TAVI), due to its non-invasive approach, has become the standard treatment in patients who are ineligible to surgery or at high surgical risk, and it is also increasingly being performed in patients at intermediate to low surgical risk. The aim is to analyze the heterogeneity and explore the limitations of current health technology assessments (HTAs) on TAVI.MethodsFor the purpose of this analysis, a review of the literature based on manual research was performed. A population, intervention, comparators, and outcome (PICO) model was used to gather the HTA reports assessing TAVI in the treatment of patients affected by symptomatic severe aortic valve stenosis at low surgical risk. Furthermore, a manual search has been developed to also include assessments from the Haute Autorité de Santé.ResultsAt the end of the investigation, a certain degree of heterogeneity in the evidence factored and in the recommendations on the technology has emerged. Relative to the clinical domains, the main drivers for the disparity are found in the type of evidence considered and in the use or not of the grading of recommendations, assessment, development, and evaluation (GRADE) methodology to evaluate the quality of the clinical evidence included. Another element concerns the chosen device generation assessed within the evaluation. In order to perform the economic evaluation, a cost-utility analysis and a budget impact model were developed. Despite some elements of heterogeneity, the economic assessments demonstrate a favorable or dominant cost-effectiveness profile for TAVI compared with surgical aortic valve replacement (SAVR).ConclusionDespite the presence of heterogeneity elements both in clinical and economic domains, HTA agencies reached the same recommendations on the use of TAVI. It emerged the need for a centralized vision on the “strong” domains, which means giving up freedom to local bodies to adapt to their context on the “soft” ones. This approach could have the potential to strengthen the role of HTA in Europe by ensuring faster decision-making and equity of access to health innovations and reduce the heterogeneity in the assessment methods.
Decolonizing global health curriculum: from fad to foundation
Authors: Kalbarczyk Anna , Perkins Sylvie , Robinson Sabreena N. , Ahmed Mahnoor K. 
Published: August 2023

IntroductionIncreasing calls have been made to decolonize global health education but there has been a lack of consensus and clarity on how this should be done. We conducted a qualitative study to understand current educational programs and curricula that aim to educate public health and allied health students to increase awareness of how colonialist structures of power influence current global health practice and provide students with tools to decolonize global health. Our goal is to inform related curriculum development and provide recommendations.MethodsWe conducted key-informant interviews with 14 study coordinators and faculty from institutions of higher learning with global health programs who are involved in developing educational approaches. All interviews were audio recorded, transcribed, and analyzed using an ‘up from the data’ approach.ResultsParticipants varied in their understanding of decolonizing global health and recognized that there is a lack of guidance in the field; this has an impact on how curriculum is developed and taught. Participants described a range of decolonizing global health educational activities in the classrooms and in applied learning activities. Most programming was situated in Diversity, Equity, and Inclusion Initiatives and participants did not always feel this was the best ‘home’ for such work; to some this reflected a lack of institutional support. Other institutional barriers included lack of protected time for faculty and limited budgets for speaker honoraria, co-creation, and related teaching expenses.DiscussionInstitutes of higher learning can play an important role, either positively or negatively, in decolonizing global health education. At a minimum such institutions should financially support faculty to incorporate decolonizing global health in their pedagogy and strengthen scholarship towards common understandings. More substantive institutional support is needed however to meaningfully transform institutional relationships that actively support equitable partnerships, co-creation, and responsiveness to local community priorities.
Pre-hospital delays among patients with acute coronary syndrome in the Russian Federation: a multicentre prospective observational cohort study (the AMIR Study)
Authors: Bates Katie , Schirmer Henrik , Kontsevaya Anna , Bobrova Natalia , Leon David A. , McKee Martin 
Published: August 2023

ObjectiveThis study aimed to describe total pre-hospital delays (symptom onset to admission), patient delays (symptom onset to calling for help), and transport delays (calling for help to admission) experienced by patients with acute coronary syndrome (ACS) in Russia and identify factors associated with longer delays.MethodsA prospective observational cohort study of ACS patients with myocardial infarction recruited in hospitals providing percutaneous coronary intervention (PCI) and those that do not (non-PCI) in 13 regions and at multiple levels of the health system in Russia. Data were collected on pre-hospital delays between symptom onset and admission to the hospital providing definitive treatment, divided into patient delay (time between symptom onset and calling for help) and transport delay (time between calling for help and admission).ResultsOf 902 patients, 701 (77.7%) had full data on pre-hospital delays. The median total pre-hospital delay in our study was 5.1 h, the median patient delay was 1.5 h, and the median transport delay was 2.1 h. Patient delays did not differ by age and sex, although having an ST-elevation myocardial infarction (STEMI) and certain symptom presentations, including severe pain, reduced delays. Transport delays were markedly reduced in those transported by emergency medical services (EMS) and taken directly to the hospital of definitive treatment (rather than to one closer but unable to offer PCI).Although transport delays were reduced in those using EMS, just half of the patients using EMS had a transport delay of &lt;2 h (first medical contact to admission). Among all patients taken directly to the hospital by EMS, 70% were STEMI patients. Of these STEMI patients, 78% had a transport delay of 2 h or more. Among these patients, only 16.0% received thrombolysis in the ambulance. As expected, regional differences were apparent with all types of delay, with the greatest variation found in transport delays.ConclusionDelays are currently longer than the European Society of Cardiology guidelines for STEMI patients and other severe cases. Reducing patient delays will reduce overall delays. Transport delays are inevitable in many regions of Russia, but better triage of patients, increased use of EMS, and early thrombolysis in EMS, particularly for STEMI patients facing excessive transport delays, will reduce delays and buy time before PCI.
The Janus face of proliferating plasmablasts in dengue and COVID-19 infections
Authors: Nayak Priya , Mukund Kavitha , Subramaniam Shankar 
Published: August 2023

IntroductionB cells play an integral role in the immune response to both dengue fever and COVID-19. Prior scRNAseq analyses of peripheral plasmablasts in COVID-19 have revealed a heterogeneous population with distinct cell subsets associated with proliferation; prior studies in patients with dengue fever have likewise shown the presence of proliferative pre-plasmablasts in the circulation. These findings may have implications for disease severity. In this study, we sought to gain a mechanistic understanding of the intracellular processes in naive and memory B cells that are associated with and may lead to an expanded proliferative plasmablast population in the circulation.MethodsWe analyzed age-controlled (pediatric and adult), peripheral blood mononuclear cell scRNAseq datasets from patients infected with either dengue (primary or secondary) or COVID-19 (non-severe or severe) from previously published studies. Our preliminary analysis showed that pediatric patients with dengue and adults with COVID-19 had an expanded proliferative plasmablast (p-PB) population. By contrast, neither the adults with dengue nor the children with COVID-19 in our dataset had p-PBs. We used this distinctive preliminary signature to guide our analyses design and expanded our analyses to naive and memory B cells.ResultsIn age/disease conditions with and without p-PBs, we found differences in cell sensing and activation, including via the B cell receptor and downstream signal transduction. Likewise, inflammation was mediated differently: relative to groups without p-PBs, those with p-PBs had increased expression of interferon response and S100 genes (particularly severe COVID-19). Furthermore, several transcription factors at the nexus of activation, inflammation, and cell fate decisions were expressed differently in groups with and without p-PBs.DiscussionWe used dengue and COVID-19 infections in adult and pediatric patients (focusing on naive B, memory B, and plasmablast cells) as a model to better understand the mechanisms that may give rise to p-PB populations in the circulation. Our results indicate that a more pro-inflammatory state in naive and memory B cells correlated with - and could influence the generation of- proliferating plasmablasts. Further exploration of these mechanisms will have implications for immune memory, vaccine development, and post-viral autoimmune syndromes.
Four types of adenine-related RNA modification writers -mediated molecular subtypes contribute to predicting clinical outcomes and treatment options in bladder cancer
Authors: Zhang Yao , Chen Ying , Wen Wen 
Published: August 2023

RationaleRNA modifications, containing m6A, m1A, alternative polyadenylation and adenosine-to-inosine RNA editing, involve in critical cancerous immunity and cancerous processes. However, the functional roles of RNA modification writers in bladder cancer (BLCA) are largely unknown.MethodsIn this study, unsupervised clustering was used to identify novel RNA modification writers -mediated molecular subtypes in BLCA. A corresponding quantitative indicator called WriterScore was developed using univariate Cox and Least absolute shrinkage and selection operator (LASSO) analysis. Then, we systematically analyzed the correlation between RNA modification writer-related clusters (WriterScore) and immunological characteristics, classical molecular subtypes, clinicopathologic features and treatment options in BLCA. Finally, we validated the WriterScore in multiple other external BLCA datasets, clinical sample dataset in Shengjing Hospital and pancancer.ResultsTwo RNA modification writer-related clusters and three DEGclusters were obtained. These RNA modification writer-related clusters (WriterScore) were strongly associated with immunological characteristics, classical molecular subtypes, clinicopathologic features of BLCA. Moreover, WriterScore can properly predict the clinical outcomes and immunotherapy of BLCA patients.ConclusionOur study systematically investigated the role of RNA modification writers and developed a significant WriterScore to guide several treatment options in BLCA, which might bring some potential benefits for BLCA patients.
Acute murine cytomegalovirus infection boosts cell-type specific response and lipid metabolism changes in the liver of infant mice
Authors: Gao Juanzi , Wang Anmin , Bu Xiangyi , Jia Weidong 
Published: August 2023

IntroductionHuman cytomegalovirus (HCMV) infection in infants can lead to severe diseases, including neonatal hepatitis. The single-cell dimensional changes in immune cells after the initial CMV infection remain elusive, as do the effects of CMV infection on hepatic lipid metabolism. MethodsWe employed single-cell RNA-sequencing to investigate the changes in liver cell types and immune responses in infant mice following murine CMV (MCMV) infection. Additionally, we examined alterations in protein expression profiles related to lipid metabolism in hepatocytes and the role of the key transcription factor PPAR-γ in hepatocytes during CMV infection. ResultsOur study revealed that MCMV infects most liver cell types in infant mice, leading to an increase in the proportion of proliferating CD8 effector T cells and a subset of Nos2+ monocytes, potentially playing an essential role in early anti-viral responses. Furthermore, MCMV infection resulted in altered protein expression of lipid metabolism in hepatocytes. Knocking down the transcription factor PPAR-γ in hepatocytes effectively inhibited CMV infection. DiscussionOur findings underscore the immune system's response to early-stage MCMV infection and the subsequent impact on hepatic lipid metabolism in infant mice. This research provides new insights into the mechanisms of CMV infection and could pave the way for novel therapeutic strategies.