bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of the Notch Signaling Pathway in Modulating the Differentiation of Main T-Lymphocytes Populations in Patients with Infiltrative Pulmonary Tuberculosis
Authors: Sanina A. E. , Serebryakova V. A. , Urazova O. I. , Gadzhiev A. A. , Stepanova E. P. , Kononova T. E. 
Published: August 2023

The objective: to evaluate the modulating effect of the Notch signaling pathway on differentiation of Th1 and Th2 lymphocytes in vitro in patients with infiltrative pulmonary tuberculosis.Subjects and Methods. 14 new patients with infiltrative pulmonary tuberculosis were enrolled in the study. Mononuclear leukocytes were isolated from blood by gradient centrifugation. Only Mycobacterium tuberculosis antigens in the form of the CFP10-ESAT6 protein or together with Y-secretase inhibitor DAPT (5 μМ/l or 10 μМ/l) were added to the incubation medium. Cells were cultured for 72 h in a complete nutrient medium with 5% CO2 at 37°C. Counts of Th1 and Th2 lymphocytes were determined by flow cytometry by evaluating the expression of CD4 receptor and intracellular transcription factors T-bet and GATA-3.Results. Cell stimulation with the CFP10-ESAT6 protein was accompanied by increasing number of Th1 and Th2 lymphocytes only in patients with pulmonary tuberculosis resistant to isoniazid + rifampicin. Adding DAPT at the concentration of 10 μМ/L to the incubation medium in these patients led to the growing number of Th1 lymphocytes and decrease in Th2 lymphocytes. In pulmonary tuberculosis patients who were susceptible to isoniazid + rifampicin, only decrease in the number of Th2-lymphocytes was regeistered. In all groups of subjects, suppression of the Notch signaling pathway led increase in the Th1/Th2 index versus Th1/Th2 stimulated with CFP10-ESAT6 antigens.
Immediate and Postponed Results of Short-Course Chemotherapy Regimens Containing Bedaquiline in Tuberculosis Patients with Multiple Drug Resistance
Authors: Golubchikov P. N. , Petrenko T. I. , Schegertsov D. Yu. , Stepanova E. P. , Pravdina I. I. , Pershina I. Yu. 
Published: August 2023

The objective: to evaluate immediate and postponed efficacy of MDR TB patients' treatment with short-course chemotherapy regimens.Subjects and Methods. Efficacy and safety of treatment with short-course chemotherapy were evaluated in 42 MDR TB patients.Results. 36 (85,7%) patients completed treatment successfully, 1 (2,4%) patient died of non-tuberculosis, and 5 (11,9%) patients defaulted from treatment. There were no such outcomes as treatment failure and died of TB. Over the 4-year follow-up period after successful treatment completion, tuberculosis relapse was detected in 1 (1,8%) patient. No adverse events that required chemotherapy discontinuation were reported, amendment of chemotherapy regimen was required in 7 (16,7%) patients.
Sistem Pendukung Keputusan Penentuan Siswa Berprestasi Dengan Metode Analytic Hierarchy Process (AHP) (Study Kasus: SMK Dharma Patra P. Berandan)
Authors: Sinuraya Bersama , Pinem Anjar , Perangin-angin Jimmy 
Published: August 2023

Teknologi Informasi dewasa ini sangat berperan, terutama dalam pengolahan data yang sifatnya kompleks, disamping itu peranannya juga dapat membantu proses pengolahannya yang tepat dan akurat, dalam penelitian ini penulis mencoba untuk mengolah data siswa, terutama penentuan siswa yang cerdas, melalui penelitian ini diyakini pihak sekolah dapat dengan mudah dan objektif menentukan siswanya yang berprestasi, dengan bantuan metode Analytical Hierarchy penelitian ini mampu menghasilkan sebuah aplikasi untuk memudahkan proses pengolahannya tersebut.
TANTANG JAWAB KREATIVITAS GURU PADA MASA PANDEMI COVID-19:
Authors: Sari May Linda , Mulyani Retni , Angela Maria , Sri Winda Yanti  
Published: August 2023

Pandemi covid-19 telah mengubah tatanan kehidupan masyarakat di semua bidang: secara sosial, ekonomi, budaya, pendidikan dan politik. Seluruh dunia terdampak, begitupun bangsa Indonesia. Sektor pendidikan adalah sektor yang cukup dipengaruhi oleh covid-19. Sekolah-sekolah dari tingkat dasar sampai tingkat perguruan tinggi harus berjuang untuk menyesuaikan diri agar mampu bertahan dalam masa Pandemi sekaligus tetap dapat melaksanakan pengajarannya dengan baik. Tulisan ini adalah hasil penelitian lapangan yang berupaya menemukan bagaimana guru-guru menjalankan kewajiban pengajaran mereka. Penelitian dijalankan melalui survei secara online kepada guru-guru Sekolah Dasar di kota Palangka Raya, Propinsi Kalimantan Tengah. Guru-guru Sekolah Dasar di kota Palangka Raya ada yang menyiasati keterbatasan ini dengan melakukan pengajaran secara daring, walaupun untuk itu mereka harus berjuang dengan berbagai macam cara. Ada tiga temuan dari hasil penelitian ini, yaitu: pertama, guru-guru SD di Kota Palangka Raya belum dipersiapkan untuk mengajar secara daring karena mereka tidak mendapatkan pelatihan tentang penggunaan IT secara terpadu, tetapi hanya belajar dari teman atau belajar sendiri. Kedua, guru-guru lebih banyak menggunakan media WhatsApp sehingga terbatas dalam memberikan pengajaran. Para guru pun mengandalkan paket data secara pribadi karena sebagian besar belum mendapat bantuan baik dari pemerintah maupun dari pihak sekolah dan ketiga, karena keterbatasan itulah, maka kreativitas para guru yang terbatas membuat cakupan pengajaran tidak bisa dilaksanakan secara maksimal.
Analisis Faktor-Faktor Yang Mempengaruhi Tingkat Upah Tenaga Kerja Pada Koperasi Simpan Pinjam Harapan Bersama Di Kabupaten Lombok Timur
Authors: Rizkyanto Hidayat Andi , Maryam St , Daeng Akung 
Published: August 2023

Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi tingkat upah tenaga kerja pada Koperasi Simpan Pinjam Harapan Bersama di Kabupaten Lombok Timur. Penelitian ini menggunakan pendekatan deskriptif kuantitatif berupa data primer dan sekunder. Model analisis yang digunakan dalam penelitian ini adalah analisis regresi linier berganda diolah menggunakan software SPSS. Populasi dalam penelitian ini adalah seluruh pegawai Koperasi. Teknik pengumpulan data yang digunakan adalah wawancara, dokumentasi dan observasi dengan menyebarkan kuesioner.
Hasil dari penelitian ini secara parsial menunjukkan bahwa tingkat pendidikan dan masa kerja berpengaruh signifikan terhadap tingkat upah, sedangkan variabel jenis kelamin dan umur tidak berpengaruh signifikan terhadap tingkat upah tenaga kerja pada Koperasi Simpan Pinjam Harapan Bersama di Kabupaten Lombok Timur. Secara simultan menunjukan bahwa tingkat pendidikan, jenis kelamin, umur, dan masa kerja berpengaruh signifikan terhadap tingkat upah tenaga kerja pada Koperasi Simpan Pinjam Harapan Bersama di Kabupaten Lombok Timur.
Influencia del índice de masa corporal en las técnicas de reproducción asistida
Authors: Viera Molina María , Borrallo Riego Álvaro , Guerra-Martín María Dolores 
Published: August 2023

Objective. To analyze the relationship between the Body Mass Index in women and the results obtained in assisted reproductive techniques.Methods. A non-experimental, cross-sectional, descriptive and correlational design was carried out through an analysis of secondary data in several assisted reproduction clinics from Spain. 3,273 medical records of women undergoing In Vitro Fertilization between 2015 and 2018 were analyzed. Data on affiliation and treatment initiation, anthropometric data, personal history, current diseases, primary and secondary infertility, as well as the reference parameters to the results after the assisted reproduction treatment were collected. The statistical analysis was performed using SPSS v19.0 software.Results. A total of 798 women (24.42%) had a BMI values ≥ 25. The overweight women achieved a lower number of oocytes retrieved and fertilized, as well as fewer embryos obtained. The women with normal weight achieved a lower number of mature oocytes and those with low weight had a lower fertilization rate.Conclusions. It has been found that the results obtained in assisted reproductive techniques are related to women's Body Mass Index.
Objetivo: Analizar la relación entre el índice de Masa Corporal en mujeres y los resultados obtenidos en las técnicas de reproducción asistida. Método: Se llevó a cabo un diseño no experimental, transversal, descriptivo y correlacional, mediante un análisis de datos secundarios en varias clínicas de reproducción asistida en España. Se analizaron 3.273 historias clínicas de mujeres sometidas a fecundación in vitro entre 2015-2018. Se recogieron datos de filiación e inicio del tratamiento, datos antropométricos, antecedentes personales, enfermedades actuales, esterilidad primaria, esterilidad secundaria, así como los parámetros referentes a los resultados tras tratamiento de reproducción asistida. El análisis estadístico se realizó mediante el software SPSS-V19.0. Resultados: 798 mujeres (24,42%) tenían un IMC ≥25. Las mujeres con sobrepeso consiguieron un menor número de ovocitos recuperados y fecundados, así como menor número de embriones obtenidos. Las mujeres con peso normal consiguieron un menor número de óvulos maduros y las mujeres con bajo peso presentaron una menor tasa de fecundación. Conclusiones: Se ha encontrado que los resultados obtenidos en las técnicas de reproducción asistida tienen relación con el índice de Masa Corporal de las mujeres.
ANÁLISIS DEL APEGO FAMILIAR AL VIAJAR CON MASCOTAS. UNA PERSPECTIVA DESDE LA DEMANDA TURÍSTICA
Authors: Marmolejo-Martín Juan Antonio , Moral-Cuadra Salvador , Aguilar-Rivero Minerva , López-Guzmán Tomás 
Published: August 2023

Pets in general, and dogs in particular, have become an important part of families and their holiday planning. This research presents the results of a survey of dog owners in Spain to find out their perceptions of the possibility of travelling with their pets. The main practical application of this research lies in presenting a series of results that can be useful for destinations that aim to attract this type of tourist to define their places as "dog friendly".
Las mascotas en general, y los perros en particular, se han convertido en una parte importante de las familias y de su planificación de las vacaciones. En esta investigación se presentan los resultados de una investigación realizada a propietarios de perros en España para conocer sus percepciones en relación con la posibilidad de viajar con sus mascotas. La principal aplicación práctica de esta investigación radica en presentar una serie de resultados que pueden ser útiles para que los destinos que pretendan atraer a esta tipología de turistas puedan definir sus lugares como “dog friendly”.
POST-COVID19 FEATURES OF SHORT-TERM RENTAL APPLICATIONS. FLEXIBILITY AS A CENTRAL ASPECT OF AIRBNB IN BARCELONA
Authors: Mansilla Jose , Quaglieri Alan , Sánchez Bergara Sheila 
Published: August 2023

The Airbnb phenomenon in Barcelona has come to occupy a central role in the local public debate. This has all been substantially altered by the global spread of COVID-19. This scenario has promoted a reformulation of the tourist rental scene, of both regular rentals and those that were also involved in the local tourism scene on an informal and/or irregular basis. In this article, we use this context as a starting point in order to analyse how this adaptation of the tourist rental sector has taken place in Barcelona, in relation to a flexible interpretation of the legislation on urban leases. In order to do that, the methodology uses is basically qualitative, although with the support of a survey in a way of triangulation system of research.
El fenómeno Airbnb en Barcelona ha pasado a ocupar un papel central en el debate público local. Todo esto ha sido sustancialmente alterado por la propagación global de COVID-19. Este escenario ha promovido una reformulación del escenario del alquiler turístico, tanto de los alquileres regulares como de aquellos que también se involucraban en el escenario turístico local de manera informal y/o irregular. En este artículo, tomamos este contexto como punto de partida para analizar cómo se ha producido esta adaptación del sector del alquiler turístico en Barcelona, en relación con una interpretación flexible de la legislación sobre arrendamientos urbanos. Para ello, la metodología utilizada es básicamente cualitativa, aunque con el apoyo de una encuesta a modo de sistema de triangulación de la investigación.
Comparison of Predictive Accuracy of the Indonesia Composite Index (ICI)
Authors: Dahlan Yunita , Hamidi Masyhuri 
Published: August 2023

This study aims to examine the effect of exchange rate and interest rates on the movement of the Composite Stock Price Index using the causality method and pattern approach. The pattern approach method predicts the movement of the stock price index through the movement pattern itself like the ARIMA method while the causality method predicts the movement of the stock price index through the variables that influence it such as the ARCH and GARCH methods. This study was conducted using monthly IHSG data, exchange rates and interest rates as of January 2014 to November 2018. From the results of the study it can be concluded that the exchange rate does not significantly influence the IDX value while the interest rate has a significant effect on the IDX, but the exchange rates and interest rates together the same has a significant negative effect on the value of the IDX. And after the two methods were compared the results were obtained that the ARIMA method gave more accurate predictive results in predicting the IHSG movement.

Abstrak

Penelitian ini bertujuan untuk menguji pengaruh variabel kurs dan suku bunga terhadap pergerakan Indeks Harga Saham Gabungan dengan menggunakan metode kausalitas dan pendekatan pola. Metode pendekatan pola memprediksi pergerakan indeks harga saham melalui pola pergerakan itu sendiri seperti metode ARIMA sedangkan metode kausalitas memprediksipergerakan indeks harga saham melalui variabel-variabel yang mempengaruhinya seperti metode ARCH dan GARCH. Penelitian ini dilakukan menggunakan data bulanan IHSG, kurs dan suku bunga per januari 2014 hingga November 2018. Dari hasil penelitian dapat disimpulkan bahwa kurs tidak berpengaruh secara signifikan terhadap nilai IHSG sedangkan suku bunga berpengaruh signifikan terhadap nilai IHSG, tetapi kurs dan suku bunga secara bersama-sama berpengaruh negatif secara signifikan terhadap nilai IHSG. Dan setelah kedua metode dibandingkan diperoleh hasil bahwa metode ARIMA memberikan hasil prediksi yang lebih akurat dalam memprediksi pergerakan IHSG.
Implementasi Pelaksanaan Rekrutmen Pada PT Jasa Kawan Indonesia
Authors: Priadinat Stefanus 
Published: August 2023

Recruitment at PT Jasa Kawan Indonesia is very important to get prospective workers who are in accordance with the qualifications and standards that have been implemented by PT Jasa Kawan Indonesia. The recruitment process has amajor influence on the achievement of the vision and mission of PT Jasa KawanIndonesia. Careless recruitment process can result in decreased company performance. Therefore, PT Jasa Kawan Indonesia conducts employee recruitment with a selection test according to the late set criteria. Primary datais information obtained from primary sources, namely information from informants. This study uses primary data and secondary data. The resultsobtained during the internship were mastering Ms. Excel and its formulas Understand how to manage tax invoices, Gain extraordinary work experience before stepping into the real world of work. Careless recruitment process can result in decreased company performance. Therefore, PT Jasa Kawan Indonesiaconducts employee recruitment with a selection test according to the late set criteria.

Abstrak (Bahasa Indonesia)

Rekrutmen pada PT Jasa Kawan Indonesia adalah hal yang sangat penting untuk mendapatkan calon pekerja yang sesuai dengan kualifikasi dan standart yang telah diterapkan oleh PT Jasa Kawan Indonesia. Proses rekrutmen berpengaruh besar dalam pencapaian visi-misi dari PT Jasa Kawan Indonesia. Proses rekrutmen yang asal-asalan dapat berakibat menurunnya kinerja perusahaan. Oleh karena itu, PT Jasa Kawan Indonesia melakukan rekrutmen pegawai dengan tes seleksi sesuai kriteria yang telat ditetapkan. Data primer merupakan informasi yang diperoleh dari sumber-sumber primer yaitu informasi dari narasumber. Penelitian ini menggunakan metode data primer dan data sekunder.Hasil yang didapatkan selama kegiatan magang adalah menguasai Ms. Excel dan rumus – rumusnya, memahami bagaimana mengurus faktur pajak, mendapatkan pengalaman kerja yang sangat luar biasa sebelum nantinya menapaki dunia kerja yang sebenarnya. Proses rekrutmen yang sebarang dapat berakibat menurunnya kinerja perusahaan. Oleh karena itu, PT Jasa Kawan Indonesia melakukan rekrutmen pegawai dengan tes seleksi sesuai kriteria yang telat ditetapkan.
Imaginaires musico-littéraires. Métamorphoses et dérèglements
Authors: Vincent-Arnaud Nathalie 
Published: August 2023

Nous menant du XIXe au XXIe siècle au fil d’un itinéraire générique et géographique varié, le présent dossier entend fournir quelques illustrations du pouvoir perturbant et métamorphosant d’un matériau musical voué au libre jeu des possibles en matière de représentation, de suggestion, de structuration ou de réorganisation d’un contenu de pensée.
Comparative Analysis of Responses to Covid 19 between Europe, Asia, America and Africa- A Literature Review of Four Nations
Authors: Abdulai Abdul-Malik , Salifu Rahma 
Published: August 2023

The COVID-19 outbreak, which emerged in the early part of 2020 and spread across the world, exposed the governance and decision-making processes as well as structural flaws in the healthcare system, but it also sparked the spirit of man to survive. The pandemic posed significant challenges to lives, health systems, and the economies of even the giant economic powers. Governments across the globe responded and continue to respond in various ways to control the spread and mitigate the consequences as much as possible.
Differences exist across the regions regarding responses to the situation. Many countries have had different experiences and travelled on different and similar trajectories in the course of the pandemic. In this review, Europe, Asia, America, and Africa are compared and contrasted in their responses to the pandemic. The responses from France, India, the United States of America, and South Africa are analysed. The first cases that were recorded, the number of cases at lockdowns, the responses to the pandemic, and the leadership role of governments are all examined.
Although the world rose to the challenge of the pandemic, it is imperative to develop deliberate global health system collaborations in the health information sector where knowledge and data are shared regularly and capacities are built to be able to mitigate quickly any future outbreak. Although the worst prediction for the African nations did not come to pass, they should individually and collaboratively develop robust healthcare systems, that can detect, prevent and manage future pandemics and also complement the global health system. There is also the need for coordination of information by national leaders to avoid conflict information that creates doubts in the minds of the people.
Bacteriological Quality Assessment of Nigerian Indigenous Beverages Consumed in Calabar, Southern Nigeria
Authors: Effiong Bassey, Emmanuel , Ebob Tarh, Jacqueline , Ikpeme Henry, Inyang , Okam Njok, Ntui 
Published: August 2023

Aim: Locally prepared drinks and beverages are gradually replacing the conventional sugary carbonated soft drinks, particularly because of the health effects associated with some of the components in these drinks. This study was aimed at evaluating the bacteriological quality of locally produced drinks/beverages (kunu, zobo, tiger-nut and pineapple drinks), produced and sold in Calabar metropolis.
Methodology: Samples (tiger-nut, zobo, kunu and pineapple drink) were collected from five different markets within the study area and evaluated using standard bacteriological techniques. Results: The mean aerobic bacterial ranged from 21.6 ± 0.8 x 105 CFU/mL to 208.8 ± 2.02 x 105 CFU/mL. The coliform counts ranged from 5.8 ± 0.49 x 105 CFU/mL to 187.2 ± 2.10 x 105 CFU/mL. The staphylococcal counts ranged from 29.8 ± 0.92 x 105 CFU/mL to 194.4 ± 1.64 x 105 CFU/mL. Coagulase-negative Staphylococci was the most predominant isolates (27.0%), followed by Escherichia coli (12.2%) and Enterobacter sp (10.4%). Other bacteria genera detected include Bacillus sp, Lactobacillus sp, Pseudomonas sp, Proteus sp, Micrococcus sp, Klebsiella sp, Serratia sp, Citrobacter sp, and Streptococcus sp and Listeria sp.
Conclusion: This study revealed that the bacteriological quality of the analyzed samples was above the acceptable standards and as such a potential risk to public health. Therefore, education for vendors on food safety and hygienic practices is essential to reduce contamination rate. Furthermore, regular inspection on food vending practices and safety of ready-to-eat foods is required to improve the health standards of consumers.
Reporting and Representation of Participant Race and Ethnicity in National Institutes of Health–Funded Pediatric Clinical Trials
Authors: Lee Lois K. , Narang Claire , Rees Chris A. , Thiagarajan Ravi R. , Melvin Patrice , Ward Valerie , Bourgeois Florence T. 
Published: August 2023

ImportanceEnrolling racially and ethnically diverse pediatric research participants is critical to ensuring equitable access to health advances and generalizability of research findings.ObjectivesTo examine the reporting of race and ethnicity for National Institutes of Health (NIH)–funded pediatric clinical trials and to assess the representation of pediatric participants from different racial and ethnic groups compared with distributions in the US population.Design, Setting, and ParticipantsThis cross-sectional study included NIH-funded pediatric (ages 0-17 years) trials with grant funding completed between January 1, 2017, and December 31, 2019, and trial results reported as of June 30, 2022.ExposuresNational Institutes of Health policies and guidance statements on the reporting of race and ethnicity of participants in NIH-funded clinical trials.Main Outcomes and MeasuresThe main outcome was reporting of participant race and ethnicity for NIH-funded pediatric clinical trials in publications and ClinicalTrials.gov.ResultsThere were 363 NIH-funded pediatric trials included in the analysis. Reporting of race and ethnicity data was similar in publications and ClinicalTrials.gov, with 90.3% (167 of 185) of publications and 93.9% (77 of 82) of ClinicalTrial.gov reports providing data on race and/or ethnicity. Among the 160 publications reporting race, there were 43 different race classifications, with only 3 publications (1.9%) using the NIH-required categories. By contrast, in ClinicalTrials.gov, 61 reports (79.2%) provided participant race and ethnicity using the NIH-specified categories (P &amp;lt; .001). There was racially and ethnically diverse enrollment of pediatric participants, with overrepresentation of racial and ethnic minority groups compared with the US population.Conclusions and RelevanceThis cross-sectional study of NIH-funded pediatric clinical trials found high rates of reporting of participant race and ethnicity, with diverse representation of trial participants. These findings suggest that the NIH is meeting its directive of ensuring diverse participant enrollment in the research it supports.