bluuebunny/crossref_metadata_2025_split huggingface dataset:
Music in the acute preoperative nursing care — A mixed‐method pilot study
Authors: Antonsen Lisa , Dieperink Karin Brochstedt , Østervang Christina 
Published: December 2022

AbstractAimThe aim was to (1) examine the feasibility aspect of a music intervention, (2) examine the association between music and pain, relaxation and well‐being and (3) explore patients' experience of listening to music while waiting for acute surgery.DesignThe design was a mixed‐method study.MethodsParticipants were offered a music pillow for 30 min. Before and after the intervention, participants reported their pain, relaxation and well‐being using a visual analogue scale ranging from 0 to10. The qualitative part was based on field observation followed by a semi‐structured interview.ResultsThe quantitative part included 30 participants. The Wilcoxon signed‐rank test showed a positive significant association between music and pain, relaxation and well‐being (p < 0.001). The qualitative part included 15 participants. Two themes derived from the analysis: (1) feelings of physical and mental well‐being and (2) a break from the acute preoperative context.Patient or Public ContributionNo patient or public contribution.
Does family‐centred education improve treatment adherence, glycosylated haemoglobin and blood glucose level in patients with type 1 diabetes? A randomized clinical trial
Authors: Mansour Mahsa , Parizad Naser , Hemmati Maslakpak Masumeh 
Published: December 2022

AbstractAimTo investigate the effect of family‐centred education on treatment adherence, glycosylated haemoglobin and blood glucose level in patients with Type 1 Diabetes Mellitus.DesignRandomized controlled trial.MethodsSixty patients with Type 1 Diabetes Mellitus were randomly allocated into the intervention and control group. Data were collected using demographic and Modanloo Adherence to Treatment Questionnaires. The patients received 12 family‐centred educational sessions in the intervention group.ResultsA significant difference was found in the mean score of treatment adherence between the two groups after the intervention (p < 0.001). The mean score of treatment adherence significantly increased in the intervention group after family‐centred education. The mean score of Fasting Blood Glucose and Glycosylated Haemoglobin A1C significantly decreased in the intervention group after the intervention (p < 0.001).ConclusionRelevant authorities need to consider family‐centred education as one of the most important education methods in Type 1 Diabetes Mellitus patients.Trial registrationIRCT20131112015390N4; August 21, 2020.
Metagenomic characterization of the maternal prenatal gastrointestinal microbiome by pregravid BMI
Authors: Dreisbach Caitlin , Alhusen Jeanne , Prescott Stephanie , Dudley Donald , Trinchieri Giorgio , Siega‐Riz Anna Maria 
Published: December 2022

AbstractObjectiveThe incidence of women entering into pregnancy with BMI indicating overweight or obesity is rising with concurrent increases in adverse complications such as gestational diabetes. Although several studies have examined the compositional changes to the microbiome across BMI classifications, there has been no investigation regarding changes in microbial function during pregnancy.MethodsA total of 105 gastrointestinal microbiome biospecimens were used in this analysis. Biospecimens were sequenced by using the Illumina NovaSeq 6000 shotgun metagenomics platform.ResultsFindings indicate an enrichment in microbiota from the phylum Firmicutes across all pregravid BMI groups with a decrease in α diversity in groups with BMI indicating obesity or overweight compared with a group with BMI indicating normal weight (p = 0.02). More specifically, women with BMI indicating obesity or overweight had enrichment in Bifidobacterium bifidum and B. adolescentis. Women with BMI > 25 kg/m2 had a higher abundance of microbiota that support biotin synthesis and regulate epithelial cells in the lower gastrointestinal tract. These epithelial cells are responsible for host adaptability to dietary lipid variation and caloric absorption.ConclusionsOur analysis suggests that there are differences in microbial composition and function between BMI groups. Future research should consider how these changes contribute to specific clinical outcomes during pregnancy.
BDF2 schemes for optimal parameter control problems governed by bilinear parabolic equations
Authors: Yang Caijie , Sun Tongjun 
Published: December 2022

SummaryIn this paper, BDF2 schemes combined with the finite element method are proposed to solve control constrained optimal parameter control problems governed by bilinear parabolic equations, where the control variable acts as a reaction coefficient. The discretize‐then‐optimize (DO) approach is adopted. First, the state equation is discretized and two different discrete formulas are utilized for the objective functional. Then, by using the Lagrange multiplier method, two fully discrete first‐order necessary optimality systems are deduced and named as DO1 and DO2 systems, respectively. It can be found that the optimize‐then‐discretize (OD) and discretize‐then‐optimize (DO) approaches coincide in the case of the DO2 system. Furthermore, a priori error estimates are derived for the state, co‐state and control variables of the DO2 system, which show that the DO2 system has second‐order accuracy in time. Finally, three numerical examples are presented to illustrate the theoretical findings.
Comprehensive and long‐term outcomes of enzyme replacement therapy followed by stem cell transplantation in children with Gaucher disease type 1 and 3
Authors: Anurathapan Usanarat , Tim‐Aroon Thipwimol , Zhang Wujuan , Sanpote Watinee , Wongrungsri Siranee , Khunin Nitcha , Chutipongtanate Somchai , Chirdkiatgumchai Vilawan , Ngiwsara Lukana , Jaovisidha Suphaneewan , Khongkraparn Arthaporn , Pakakasama Samart , Svasti Jisnuson , Setchell Kenneth D. R. , Wattanasirichaigoon Duangrurdee , Hongeng Suradej 
Published: December 2022

AbstractBackgroundGaucher disease (GD) is a lysosomal storage disorder, characterized by hepatosplenomegaly, pancytopenia, bone diseases, with or without neurological symptoms. Plasma glucosylsphingosine (lyso‐Gb1), a highly sensitive and specific biomarker for GD, has been used for diagnosis and monitoring the response to treatment. Enzyme replacement therapy (ERT) is an effective treatment for the non‐neurologic symptoms of GD. Neuronopathic GD (type 2 and 3) accounts for 60%–70% of the Asian affected population.MethodsWe explored combination therapy of ERT followed by hematopoietic stem cell transplantation (HSCT) and its long‐term outcomes in patients with GD type 3 (GD3).ResultsFour patients with GD3 and one with GD type 1 (GD1) underwent HSCT. The types of donor were one matched‐related, one matched‐unrelated, and three haploidentical. The age at disease onset was 6–18 months and the age at HSCT was 3.8–15 years in the patients with GD3. The latest age at follow‐up was 8–22 years, with a post‐HSCT duration of 3–14 years. All patients had successful HSCT. Chronic graft‐versus‐host disease occurred in one patient. The enzyme activities were normalized at 2 weeks post HSCT. Lyso‐Gb1 concentrations became lower than the pathological value. All of the patients are still alive and physically independent. Most of them (4/5) returned to school. None of the patients with GD3 had seizures or additional neurological symptoms after HSCT, but showed varying degrees of cognitive impairment.ConclusionsERT followed by HSCT could be considered as an alternative treatment for patients with GD3 who have a high risk of fatal neurological progression.
Temperature and illumination dependence of silicon heterojunction solar cells with a wide range of wafer resistivities
Authors: Le Anh Huy Tuan , Srinivasa Apoorva , Bowden Stuart G. , Hameiri Ziv , Augusto André 
Published: December 2022

AbstractRecently, the significant improvements in the surface and contact passivation of silicon (Si) solar cells as well as their bulk quality have shifted their operating point to higher injections. Hence, they are less dependent on wafer doping. This shift opens an opportunity of using high‐resistivity wafers for practical photovoltaic applications, introducing a promising approach to push the cell efficiency towards the intrinsic limit and to improve the module reliability by increasing the cell breakdown voltage. Therefore, insights into the performance of Si solar cells using high‐resistivity wafers at various operating temperatures are of significant interest. In this study, we investigate the temperature‐ and illumination‐dependent performance of Si heterojunction (SHJ) solar cells using a wide range of wafer resistivities (between 3 and 1000 Ω⋅cm). Although a reduction in the passivation quality of the passivating contacts is observed at elevated temperature, the impact on the temperature coefficient of the open‐circuit voltage (TCVoc)—the dominant contributor to the temperature coefficient (TC) of the cell efficiency—is very limited. Their TCVoc are still dominated by the temperature dependence of the effective intrinsic carrier concentration. Furthermore, we also find that the investigated cells are more sensitive to temperature variation at lower illumination intensities. It is noteworthy that the efficiency of the cells fabricated using high‐resistivity wafers is comparable to that of the reference cells at any given temperature, highlighting the potential of using high‐resistivity wafers for solar cells.
Plasma‐electrified postharvest preservation of Citrus sinensis: Process technology and freshness‐keeping and anticorrosion effects
Authors: Liu Kun , Ran Congfu , Geng Wenqing , Han Leng , Ostrikov Kostya K. 
Published: December 2022

AbstractNitrogen oxide‐generating dielectric barrier discharge plasma is shown to effectively inhibit microorganisms and maintain fruit freshness. Physical and biological mechanisms of the plasma‐electrified fungicidal effects suggest that plasma‐generated NO and ONOO− species and other factors are crucial to regulating physiological senescence in citrus fruit while controlling pathogens on their surface. The revealed Physico‐chemical effects explain the observed phenotypic changes and the suppression of surface pathogens, thus providing mechanistic insights into postharvest fruit processing with plasmas.
Holocene January paleotemperature of northwestern Siberia reconstructed based on stable isotope ratio of ice wedges
Authors: Vasil'chuk Yurij K. , Vasil'chuk Alla C. , Budantseva Nadine A. 
Published: December 2022

AbstractIce wedges are considered as a paleoarchive of winter air temperatures as their stable isotope composition has been widely used to reconstruct winter climatic conditions in the Arctic regions. Ice wedge stable isotope records, obtained in recent decades for many Arctic permafrost areas of Russia and North America, demonstrate a clear shift from lower to higher values between the Late Pleistocene and Holocene (by 5–10‰ for δ18O values in some regions of the Russian Arctic), which is widely accepted as evidence of winter air temperature increase. However, the evolution of winter air temperatures during the Holocene is less clear and, according to proxy reconstructions, winter climate trends are not synchronous and may significantly vary throughout the Arctic. In this study, we investigate the stable isotope composition of Holocene syngenetic ice wedges and modern ice veinlets of northwestern Siberia. Radiocarbon dating of enclosing sediments and a few dates of organic material from ice wedges demonstrate that ice wedges grew constantly within the study area during the Holocene though early–mid‐Holocene in northwestern Siberia is often considered as a thermal optimum. In fact, many proxy records indicate an increase of summer air temperatures followed by thermokarst activity, peatland formation, and northward advance of the treeline. According to our data, winter climate conditions in terms of mean air temperature of the coldest winter month (January) did not change significantly during the key Holocene stages, and during the Greenlandian and most of the Northgrippian stages (between 11.4 and 6 cal ka BP) mean January air temperature (TmJ) varied between −21 and −30°C, and from the end of the Northgrippian, during the Meghalayan stages of Holocene (5.2–0.9 cal ka BP), TmJ varied between −24 to −28°C. Mean January air temperature during the Holocene was generally 1–2°C lower than the modern one, meanwhile the submeridional direction of TmJ isotherms and eastward decrease of TmJ values in Holocene are similar to the modern pattern.
Novel quinolin‐2(1H)‐one analogues as potential fungicides targeting succinate dehydrogenase: design, synthesis, inhibitory evaluation and molecular modeling
Authors: Wang Jingwen , Lu Tong , Xiao Tingting , Cheng Wei , Jiang Wenjing , Yan Yingkun , Tang Xiaorong 
Published: December 2022

AbstractBACKGROUNDSuccinate dehydrogenase is an important target of fungicides. Succinate dehydrogenase inhibitors (SDHIs) have widely been used to combat destructive plant pathogenic fungi because they possess efficient and broad‐spectrum antifungal activities and as well as unique mode of action. The research and development of novel SDHIs have been ongoing.RESULTSThirty‐six novel quinolin‐2(1H)‐one derivatives were designed, synthesized and characterized. The single crystal structure of compound 3c was determined through the X‐ray diffraction of single crystals. The bioassay results displayed that most compounds had good antifungal activities at 16 μg mL−1 against Rhizoctonia cerealis, Erysiphe graminis, Botrytis cinerea, Penicillium italicum and Phytophthora infestans. Compounds 6o, 6p and 6r had better antifungal activities than the commercialized fungicide pyraziflumid against Botrytis cinerea. Their half maximal effective concentration (EC50) values were 0.398, 0.513, 0.205 and 0.706 μg mL−1, respectively. Moreover, the inhibiting activities of the bioactive compounds were tested against succinate dehydrogenase. The results indicated that they possessed outstanding activities. Compounds 6o, 6p and 6r also exhibited better inhibiting activities than pyraziflumid against succinate dehydrogenase. Their half maximal inhibitory concentration (IC50) values were 0.450, 0.672, 0.232 and 0.858 μg mL−1, respectively. The results of molecular dynamic (MD) simulations indicated that compound 6r displayed stronger affinity to succinate dehydrogenase than pyraziflumid.CONCLUSIONThe results of the present study displayed that quinolin‐2(1H)‐one derivative could be one scaffold of potential SDHIs and will provide some valuable information for the research and development of new SDHIs. © 2022 Society of Chemical Industry.
Pre and post‐COVID 19 infection pulmonary functions in children with chronic respiratory disease: A case series
Authors: Ramadan Salim , Nguyen The Thanh Diem , Laberge Sophie , Marcotte Jacques‐Edouard , Zisman‐Colman Zofia , Tse Sze Man 
Published: December 2022

AbstractAs functional respiratory impairment following COVID‐19 infection (COVID‐19) is increasingly reported in adult, data regarding children especially with pre‐existing chronic respiratory disease (PCRD) remain scarce. We retrospectively assessed clinical presentation, duration of symptoms related to COVID‐19 from paediatric patients with PCRD and compared their pre/post COVID‐19‐I spirometry values. Data from 12 patients were analysed. Timing between COVID‐19 diagnosis and subsequent functional evaluation ranged from 26 to 209 days (mean 77). The PCRD in these patients included asthma, cystic fibrosis, bronchiolitis obliterans and bronchomalacia. During COVID‐19, all clinical presentations were mild. One patient displayed persistent post‐COVID‐19 symptoms for 8 weeks after infection. Two patients presented significant deterioration of post‐COVID‐19 spirometric values with a return to pre‐COVID‐19 values in subsequent measures. We concluded that children with PCRD are not at increased risk for severe COVID disease and that most of them have no or only transient pulmonary functional impairment 1 to 7 months after COVID‐19.
Investigation of Impact Properties of Carboxylated‐terminated Liquid Acrylonitrile Rubber and Cerium Oxide Nano Double‐toughened Epoxy Resin
Authors: Wang Wenzhi , Yang Jin , Yang Jinpeng , Yang Jundong , Liang Dayu , Lu Zhimin 
Published: December 2022

AbstractThe excellent physical properties of epoxy resin are not available in other thermoplastic materials, but the toughness of pure species samples is relatively poor. In this experiment, epoxy resin was toughened by adding carboxylated‐terminated liquid acrylonitrile rubber and cerium oxide nanoparticles. The samples were subjected to performance tests, including impact tests, scanning electron microscopy, Energy Dispersive Spectroscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, and Thermal stability analysis. Based on the analysis of the performance test results, the best toughening mass ratio of the raw material of the double toughened epoxy resin was obtained. The mass ratio of epoxy resin to double toughening agent was 4 : 1. In the double toughening agent, the mass ratio of carboxylated‐terminated liquid acrylonitrile rubber to cerium oxide nano was 4 : 1. The impact strength of the double toughened epoxy resin at the optimum toughened mass ratio can reach 31.77 KJ/m2. This is an impact strength increase of 692 % compared with the pure epoxy resin.
A New Sono‐Chemo Sensitizer Overcoming Tumor Hypoxia for Augmented Sono/Chemo‐Dynamic Therapy and Robust Immune‐Activating Response
Authors: Sun Luyao , Gao Wendong , Wang Jingjing , Niu Xueming , Kurniawan Nyoman , Li Li , Xu Zhi Ping 
Published: December 2022

AbstractNovel sonosensitizers with intrinsic characteristics for tumor diagnosis, efficient therapy, and tumor microenvironment regulation are appealing in current sonodynamic therapy. Herein, a manganese (Mn)‐layered double hydroxide‐based defect‐rich nanoplatform is presented as a new type of sono‐chemo sensitizer, which allows ultrasound to efficiently trigger reactive oxygen species generation for enhanced sono/chemo‐dynamic therapy. Moreover, such a nanoplatform is able to relieve tumor hypoxia and achieve augmented singlet oxygen production via catalyzing endogenous H2O2 into O2. On top of these actions, the released Mn2+ ions and immune‐modulating agent significantly intensify immune activation and reverse the immunosuppressive tumor microenvironment to the immunocompetent one. Consequently, this nanoplatform exhibits excellent anti‐tumor efficacy and effectively suppresses both primary and distant tumor growth, demonstrating a new strategy to functionalize nanoparticles as sono‐chemo sensitizers for synergistic combination cancer therapy.
A High‐Performance Hybrid Biofuel Cell with a Honeycomb‐Like Ti3C2Tx/MWCNT/AuNP Bioanode and a ZnCo2@NCNT Cathode for Self‐Powered Biosensing
Authors: Sun Yuping , Qin Tengteng , Liu Xiaoqiang , Liu Yuan , Zhao Dan , Wong Danny K.Y. 
Published: December 2022

AbstractThis work focusses on developing a hybrid enzyme biofuel cell‐based self‐powered biosensor with appreciable stability and durability using murine leukemia fusion gene fragments (tDNA) as a model analyte. The cell consists of a Ti3C2Tx/multiwalled carbon nanotube/gold nanoparticle/glucose oxidase bioanode and a Zn/Co‐modified carbon nanotube cathode. The bioanode uniquely exhibits strong electron transfer ability and a high surface area for the loading of 1.14 × 10−9 mol cm−2 glucose oxidase to catalyze glucose oxidation. Meanwhile, the abiotic cathode with a high oxygen reduction reaction activity negates the use of conventional bioenzymes as catalysts, which aids in extending the stability and durability of the sensing system. The biosensor offers a 0.1 fm–1 nm linear range and a detection limit of 0.022 fm tDNA. Additionally, the biosensor demonstrates a reproducibility of ≈4.85% and retains ≈87.42% of the initial maximal power density after a 4‐week storage at 4 °C, verifying a significantly improved long‐term stability.
The Impact of Carbon Nanotube Length and Diameter on their Global Alignment by Dead‐End Filtration
Authors: Rust Christian , Shapturenka Pavel , Spari Manuel , Jin Qihao , Li Han , Bacher Andreas , Guttmann Markus , Zheng Ming , Adel Tehseen , Walker Angela R. Hight , Fagan Jeffrey A. , Flavel Benjamin S. 
Published: December 2022

AbstractDead‐end filtration has proven to effectively prepare macroscopically (3.8 cm2) aligned thin films from solutionbased single‐wall carbon nanotubes (SWCNTs). However, to make this technique broadly applicable, the role of SWCNT length and diameter must be understood. To date, most groups report the alignment of unsorted, large diameter (≈1.4 nm) SWCNTs, but systematic studies on their small diameter are rare (≈0.78 nm). In this work, films with an area of A = 3.81 cm2 and a thickness of ≈40 nm are prepared from length‐sorted fractions comprising of small and large diameter SWCNTs, respectively. The alignment is characterized by cross‐polarized microscopy, scanning electron microscopy, absorption and Raman spectroscopy. For the longest fractions (Lavg = 952 nm ± 431 nm, Δ = 1.58 and Lavg = 667 nm ± 246 nm, Δ = 1.55), the 2D order parameter, S2D, values of ≈0.6 and ≈0.76 are reported for the small and large diameter SWCNTs over an area of A = 625 µm2, respectively. A comparison of Derjaguin, Landau, Verwey, and Overbeek (DLVO) theory calculations with the aligned domain size is then used to propose a law identifying the required length of a carbon nanotube with a given diameter and zeta potential.
An Organic Redox Mediator with a Defense‐Donor for Lithium Anode in Lithium–Oxygen Batteries
Authors: Sun Zongqiang , Tan Yanyan , Zhan Yingjie , Li Kaixuan , Dou Wenjie , Wang Chutao , Lin Xiaodong , Yuan Ruming , Yan Jiawei , Zheng Mingsen , Dong Quanfeng 
Published: December 2022

AbstractLithium–oxygen batteries (LOBs) suffer from large charge overpotential and unstable Li metal interface, which can be attributed to the inefficient charge transport at the insulating Li2O2/cathode interface and the severe oxygen corrosion issue on the Li anode surface. The use of soluble redox mediators (RMs) can effectively enhance the charge transport between Li2O2 and cathode, thus greatly reducing the charge overpotential. However, oxidized RMs will also shuttle to the anode side and react with the Li metal, which not only results in the loss of both the RMs and the electrical energy efficiency but also exacerbates the Li anode corrosion. Herein, an organic compound—acetylthiocholine iodide (ATCI), in which a big cation group is contained, is proposed as a defense‐donor RM for lithium anode in LOBs to simultaneously address the above issues. During charge, it can accelerate the oxidation kinetics of Li2O2 via its iodide anion redox couple (I−/I3−). Meanwhile, its cation segment (ATC+) can move to the anode surface via electric attraction and in situ forms a protective interfacial layer, which prevents the Li anode from the attack of oxidized RM and oxygen species. Consequently, the ATCI‐containing LOBs can achieve both a low charge potential (≈3.49 V) and a long cycle life (≈190 cycles).