bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cholesterol in the cargo membrane amplifies tau inhibition of kinesin-1-based transport
Authors: Li Qiaochu , Ferrare James T. , Silver Jonathan , Wilson John O. , Arteaga-Castaneda Luis , Qiu Weihong , Vershinin Michael , King Stephen J. , Neuman Keir C. , Xu Jing 
Published: January 2023

Intracellular cargos are often membrane-enclosed and transported by microtubule-based motors in the presence of microtubule-associated proteins (MAPs). Whereas increasing evidence reveals how MAPs impact the interactions between motors and microtubules, critical questions remain about the impact of the cargo membrane on transport. Here we combined in vitro optical trapping with theoretical approaches to determine the effect of a lipid cargo membrane on kinesin-based transport in the presence of MAP tau. Our results demonstrate that attaching kinesin to a fluid lipid membrane reduces the inhibitory effect of tau on kinesin. Moreover, adding cholesterol, which reduces kinesin diffusion in the cargo membrane, amplifies the inhibitory effect of tau on kinesin binding in a dosage-dependent manner. We propose that reduction of kinesin diffusion in the cargo membrane underlies the effect of cholesterol on kinesin binding in the presence of tau, and we provide a simple model for this proposed mechanism. Our study establishes a direct link between cargo membrane cholesterol and MAP-based regulation of kinesin-1. The cholesterol effects uncovered here may more broadly extend to other lipid alterations that impact motor diffusion in the cargo membrane, including those associated with aging and neurological diseases.
Molecular imaging of chemokine-like receptor 1 (CMKLR1) in experimental acute lung injury
Authors: Mannes Philip Z. , Barnes Clayton E. , Biermann Jana , Latoche Joseph D. , Day Kathryn E. , Zhu Qin , Tabary Mohammadreza , Xiong Zeyu , Nedrow Jessie R. , Izar Benjamin , Anderson Carolyn J. , Villanueva Flordeliza S. , Lee Janet S. , Tavakoli Sina 
Published: January 2023

The lack of techniques for noninvasive imaging of inflammation has challenged precision medicine management of acute respiratory distress syndrome (ARDS). Here, we determined the potential of positron emission tomography (PET) of chemokine-like receptor-1 (CMKLR1) to monitor lung inflammation in a murine model of lipopolysaccharide-induced injury. Lung uptake of a CMKLR1-targeting radiotracer, [
64
Cu]NODAGA-CG34, was significantly increased in lipopolysaccharide-induced injury, correlated with the expression of multiple inflammatory markers, and reduced by dexamethasone treatment. Monocyte-derived macrophages, followed by interstitial macrophages and monocytes were the major CMKLR1-expressing leukocytes contributing to the increased tracer uptake throughout the first week of lipopolysaccharide-induced injury. The clinical relevance of CMKLR1 as a biomarker of lung inflammation in ARDS was confirmed using single-nuclei RNA-sequencing datasets which showed significant increases in
CMKLR1
expression among transcriptionally distinct subsets of lung monocytes and macrophages in COVID-19 patients vs. controls. CMKLR1-targeted PET is a promising strategy to monitor the dynamics of lung inflammation and response to anti-inflammatory treatment in ARDS.
Developing and evaluating a contextualized interactional competence rating scale based on a metaphorical
conceptualization
Authors: Neiriz Reza 
Published: January 2023

Abstract
Rating scales developed to measure interactional competence (IC) are mainly data-driven which can incur
unaffordable costs for assessment practitioners with limited resources, such as universities using this test for placement
purposes. A cheaper alternative is to use models proposed in the literature to develop such rating scales. This mixed-methods
study evaluates a contextualized analytic IC rating scale developed based on Galaczi and
Taylor’s (2018) metaphorical conceptualization of IC. A many-facet Rasch analysis indicated this rating scale could
separate examinees into three levels of ability, which was lower than the expected four levels. To explore this finding, raters
were interviewed about their experiences of using this rating scale. The findings show the potential and limitations of developing
contextualized IC ratings scales based on literature and possible avenues for future research. They also suggest a direct
interaction between assessment and instructional practices of IC with implications for language teaching.
Diaries and journals in study abroad research
Authors: Plews John L. , Misfeldt Kim , Feddersen Richard 
Published: January 2023

Abstract
This chapter examines journals as a method for gathering qualitative study abroad (SA) research data. We define various kinds of journals, trace their implementation, assess their contributions, and discuss their limitations. Journals-based SA research has shown individual variation, the impact of the cultural context on gendered and racialized participants, the influence of communicative competence and use on the intellectual and social sense of self, the importance of goal setting and learner agency, and the learning potential of journals as assignments with feedback. Limitations in SA research using journals concern data analysis, data presentation, and the consideration of the benefit to participants. We encourage SA researchers to work within the transformative paradigm, demonstrate comprehensive contemplative proximity, use formal analytical frameworks, and consider especially supported written reflection in the L2.
Narratives and identity in study abroad research
Authors: Tyne Henry 
Published: January 2023

Abstract
Study abroad can be seen as a journey through time and space, affording narratives. This chapter focuses on the study of narratives and questions of identity for study abroad research. Looking first at narrative inquiry in general, it then considers the use of narratives in second language acquisition studies, before going on to address issues arising in study abroad research in particular. Identity is discussed in relation to narratives and narrative inquiry. Limitations and issues arising in existing studies are discussed, and suggestions are given for working with narratives in future study abroad research.
Investigating pragmatic development in study abroad contexts
Authors: Nightingale Richard , Alcón-Soler Eva 
Published: January 2023

Abstract
A study abroad (SA) period is considered an optimum environment for developing pragmatic competence because of the unparalleled target-language access it provides. Within this context, pragmatic development has received extensive attention over the last two decades, during which we have seen an evolution in research orientations. Existing studies employ quantitative, qualitative, and mixed methods approaches, building on each other to paint a picture of SA pragmatic development as an inherently dynamic process contingent on interdependence between a range of cognitive, affective, behavioural, and contextual factors. This chapter will reflect on existing research in this area, focusing on the approach, contributions, and limitations of a range of studies, as well as highlighting research desiderata and recommending research directions for future studies.
Is ambient it truly non-referential?
Authors: Mathurin Élise 
Published: January 2023

Abstract
This chapter examines the non-referential status frequently ascribed to ambient it (i.e. the pronoun it used with weather verbs and expressions of time and distance). In line with Langacker (2011), I aim to show that this use of the pronoun it is in fact referential. First, I examine the reasons why ambient it is traditionally denied a referential status and propose counter arguments. I then argue that a speaker always conveys a referential intention when using ambient it (frequently accompanied by an ostension gesture). The pointed referent, although completely obvious, is vague and difficult to name and delimit. Finally, I analyze cases that share characteristics with ambient it but that cannot be entirely included in the same category.
Electric vehicles in the press
Authors: Vargas Elodie , Machy Jérémy 
Published: January 2023

Abstract
The chapter proposes a corpus-based study of references to electric vehicles, a controversial technological innovation. The aim is to see whether representations, especially as conveyed through referential expressions, show any convergences, whether within a given publication or a given country. The corpus comprises 130 online articles from French and German national daily newspapers (2015–2020), with a special focus on 2017–2018, which witnessed many changes in reporting on electric vehicles. The study finds that referential expressions partly differ in the two countries, especially as regards metaphors. It also shows that referential expressions can only be interpreted in context. A seemingly “neutral” noun phrase may carry strong economic, political and cultural orientations. As such, it is highly subjective, an instrument of power.
Who creates reference?
Authors: Consten Manfred 
Published: January 2023

Abstract
This contribution sketches the role of hearers in the long history of reference research. Canonical approaches from semantics and (early) pragmatics as well as cognitive approaches are discussed with respect to the increasing role that hearers play in these various notions of reference. In the framework of Text-world model theory, reference objects are considered to be mental concepts that can vary as discourse progresses, as a result of a negotiation between speakers and hearers. Examples from German oral conversation corpora show that reference should be described as a collaborative, interactive procedure in order to get a notion of reference that is compatible with and useful for the analysis of conversation phenomena.
Mechanically coupled cantilever beam structure for piezoelectric energy harvesting
Authors: Batra Nitika , Deol Rajinder Singh , Singh Madhusudan , Mitra Bhaskar 
Published: January 2023

Abstract
In this paper, we report a wideband energy harvester where mechanical coupling of the cantilever beams in cascaded configuration employed using long and thin spring like structures to couple individual harvesters. The outcomes of designing uni-beam, dual-beam, tri-beam, and quad-beam coupled energy harvesters are compared using COMSOL as well as experimentally. Simulation results indicated that quad-beam coupled energy harvesters had a bandwidth of 11.9 Hz. Physical devices were fabricated in silicon and tested using PVDF-TrFE piezoelectric material and showed a bandwidth enhancement from 0.7 to 8.9 Hz. The coupling scheme may be extended to larger arrays to increase bandwidth further as per requirements.
Reconstructed lung doses for the million person study cohort of 26,650 Tennessee Eastman corporation workers employed between 1942 and 1947
Authors: Bellamy Michael , Eckerman Keith , Dauer Lawrence 
Published: January 2023

Abstract
Tennessee Eastman Corporation workers were exposed to uranium dust resulting in high-linear energy transfer (LET) irradiation to lung tissue. In this work, radiation lung doses were reconstructed for 26 650 men and women working at the plant between 1942 and 1947. Site air monitoring data of uranium concentrations and payroll records were used to determine the daily inhaled activities and annualized lung doses. Variations in the activity median aerodynamic diameter of the uranium dust, the solubility of particulate matter in the lungs and the sex-specific breathing rate were investigated as part of a sensitivity analysis. Male and female mean lung doses of 18.9 and 32.7 mGy, respectively, from high-LET alpha irradiation, and there was general agreement with evaluations from previously published epidemiological studies. Annual lung dose estimates and sensitivity analysis for the 26 650 workers in the TEC cohort have been archived on the United States Department of Energy Comprehensive Epidemiologic Data Resource.
Dose reference level based on size-specific dose estimate (SSDE) and feasibility of deriving effective body diameter using tube current and time product (mAs) for adult chest and abdomen computed tomography (CT) procedures
Authors: Amalaraj T , Jeyasugiththan Jeyasingam , Satharasinghe Duminda , Pallewatte A S 
Published: January 2023

Abstract
This study aimed to establish dose reference level (NDRL

S
S
D
E

) based on size-specific dose estimate (SSDE) derived using effective diameter (

D

e
f
f

) for adult chest and abdomen computed tomography (CT) procedures and to explore the feasibility of driving

D

e
f
f

using the product of tube current and time (mAs). In this retrospective study, dose data, scan parameters and patient body dimensions at the mid-slice level from 14 CT units (out of 63 total) were extracted. Additionally, the mAs values of the axial slice at the same z-location where the diameter measurements were made (mAs
z
) were recorded. Pearson’s correlation (r) analysis was used to determine the relationship of

D

e
f
f

with patient BMI, weight, and mAs
z
. The NDRL

S
S
D
E

for the chest and abdomen were 9.72 mGy and 13.4 mGy, respectively. The BMI and body weight were less correlated (r = 0.24 and r = 0.33, respectively) with

D

e
f
f

. The correlation between mAs
z
and

D

e
f
f

was considerably strong (r = 0.78) and can be used to predict

D

e
f
f

accurately. The absolute dose differences between SSDEs calculated using the AAPM–204 method and mAs
z
was less than 1.1 mGy (15%). Therefore, mAs
z
is an efficient parameter to derive

D

e
f
f

. Further, the direct conversion factors to estimate SSDEs at different locations along the z-direction in the scan region from corresponding mAs and CTDI

v
o
l

were calculated. The NDRL

S
S
D
E

suggested in the present study can be used as a reference for size-dependent dose optimisation in Sri Lanka, and existing NDRL based on CTDI

v
o
l

underestimate the average adult CT dose by 36.0% and 39.7% for chest and abdomen regions respectively. The results show that using mAs
z
to determine SSDE is a simple and practical approach with an accuracy of 95% and 85% for abdomen and chest scans, respectively. However, the obtained linear relationship between

D

e
f
f

and mAs is highly dependent on the ATCM technique and the user-determined noise levels of the scanning protocol. Finally, the phantom study resulted in the strongest correlation (r = 0.99) between the D

w

z

and mAs
z
, and the prediction of patient size would be more precise than

D

e
f
f

method.
Surface plasmon polariton assisted near perfect light absorption from corrugated metal–insulator–metal structure exploiting lossy metal films
Authors: Wu Shin-Hong , Su Po-Han , Kan Hung-Chih 
Published: January 2023

Abstract
We propose and demonstrate a lithography-free self-assembled corrugated Cr/TiO2/Cr metal–insulator–metal (Cr-cMIM) structure on silica opal substrates for broadband near perfect light absorption applications. Our optimal Cr-cMIM structure have reached a spectral average absorption rate above 98% over the visible wavelength range. We carried out numerical calculations to simulate the interaction between the incident light and the Cr-cMIM structure. The simulated absorption spectra qualitatively reproduced the experimental results. Detailed analysis of the simulation results indicates that the corrugation of the Cr layers successfully couples the incident light with the localized surface plasmon polariton. The incorporation of the surface plasmonic excitation and the intrinsic ohmic dissipation of the Cr layers results in the broadband near perfect light absorption over the visible wavelength range.
A 3D re-entrant structural metamaterial with negative Poisson’s ratio reinforced by adding arrow structures
Authors: Wang Jie , Wu Zongze , Xiao Rui , Tang Changyu , Xu Yangguang 
Published: January 2023

Abstract
Structural metamaterial with negative Poisson’s ratio often has low stiffness due to its porous structure. For engineering applications, the various strategies have been developed to enhance its stiffness but also weaken the negative Poisson effect. In this work, we propose a 3D reinforced re-entrant structure (RRS) by adding arrow structures to the classical re-entrant structure (RS), which is fabricated by photocuring 3D printing of photosensitive resin. The structure-properties correlative mechanism of RRS is systematically analyzed by combining experiment (quasi-static compression experiment) and finite element simulation (ABAQUS). It is found that the equivalent elastic modulus and negative Poisson’s ratio of RRS can be tuned by various structural parameters (i.e. the thickness ratio η, the length ratio of the slant rod α, the length ratio of the vertical rod β, and the angle θ of the re-entrant cells). By optimizing the structure parameters, the equivalent elastic modulus of RRS with the negative Poisson’s ratio of −0.28 can be significantly increase to 13.67 MPa, which is 12.32 times larger than that of RS with the same negative Poisson’s ratio. Due to the flexible design of stiffness and negative Poisson ratio, our proposed 3D reinforced re-entrant structural metamaterial provides a potential way for designing engineering materials with desirable performance.
Testing primordial black hole and measuring the Hubble constant with multiband gravitational-wave observations
Authors: Liu Lang , Yang Xing-Yu , Guo Zong-Kuan , Cai Rong-Gen 
Published: January 2023

Abstract
There exist two kinds of stochastic gravitational-wave backgrounds associated with the
primordial curvature perturbations. One is called induced gravitational wave due to the nonlinear
coupling of curvature perturbations to tensor perturbations, while the other is produced by
coalescences of binary primordial black holes formed when the large amplitude curvature
perturbations reenter the horizon in the radiation dominant era. In this paper we find a quite
useful relation for the peak frequencies of these two stochastic gravitational-wave backgrounds.
This relation can not only offer a smoking-gun criterion for the existence of primordial black
holes, but also provide a method for measuring the Hubble constant H
0 by multiband observations
of the stochastic gravitational-wave backgrounds.
Diffusive exit rates through pores in membrane-enclosed structures
Authors: Yang Zitao , Koslover Elena F 
Published: January 2023

Abstract
The function of many membrane-enclosed intracellular structures relies on release of diffusing particles that exit through narrow pores or channels in the membrane. The rate of release varies with pore size, density, and length of the channel. We propose a simple approximate model, validated with stochastic simulations, for estimating the effective release rate from cylinders, and other simple-shaped domains, as a function of channel parameters. The results demonstrate that, for very small pores, a low density of channels scattered over the boundary is sufficient to achieve substantial rates of particle release. Furthermore, we show that increasing the length of passive channels will both reduce release rates and lead to a less steep dependence on channel density. Our results are compared to previously-measured local calcium release rates from tubules of the endoplasmic reticulum, providing an estimate of the relevant channel density responsible for the observed calcium efflux.
Patient-independent seizure detection based on long-term iEEG and a novel lightweight CNN
Authors: Si Xiaopeng , Yang Zhuobin , Zhang Xingjian , Sun Yulin , Jin Weipeng , Wang Le , Yin Shaoya , Ming Dong 
Published: January 2023

Abstract

Objective. Patient-dependent seizure detection based on intracranial electroencephalography (iEEG) has made significant progress. However, due to the difference in the locations and number of iEEG electrodes used for each patient, patient-independent seizure detection based on iEEG has not been carried out. Additionally, current seizure detection algorithms based on deep learning have outperformed traditional machine learning algorithms in many performance metrics. However, they still have shortcomings of large memory footprints and slow inference speed. Approach. To solve the above problems of the current study, we propose a novel lightweight convolutional neural network model combining the Convolutional Block Attention Module (CBAM). Its performance for patient-independent seizure detection is evaluated on two long-term continuous iEEG datasets: SWEC-ETHZ and TJU-HH. Finally, we reproduce four other patient-independent methods to compare with our method and calculate the memory footprints and inference speed for all methods. Main results. Our method achieves 83.81% sensitivity (SEN) and 85.4% specificity (SPE) on the SWEC-ETHZ dataset and 86.63% SEN and 92.21% SPE on the TJU-HH dataset. In particular, it takes only 11 ms to infer 10 min iEEG (128 channels), and its memory footprint is only 22 kB. Compared to baseline methods, our method not only achieves better patient-independent seizure detection performance but also has a smaller memory footprint and faster inference speed. Significance. To our knowledge, this is the first iEEG-based patient-independent seizure detection study. This facilitates the application of seizure detection algorithms to the future clinic.
Self-consistent investigation of density fueling needs on ITER and CFETR utilizing the new Pellet Ablation Module
Authors: McClenaghan J. , Lao L.L. , Parks P.B. , Wu W. , Zhang J. , Chan V.S. 
Published: January 2023

Abstract
Self-consistent modeling using the stability, transport, equilibrium, and pedestal (STEP) workflow in the OMFIT integrated modeling framework (predicting pedestal with EPED, core profiles with TGYRO, current profile with ONETWO, and EFIT for equilibrium) suggests ITER and future devices such as China Fusion Engineering Test Reactor (CFETR) Zhuang et al (2019 Nucl. Fusion
59 112010) will benefit from high-density operation (Greenwald limit fraction

f

g
w

≈

0.7−1.3). Regimes with an operational density near the Greenwald limit will likely need peaked density profiles so that the pedestal density remains below the Greenwald limit. Peaked density profiles can be achieved with the help of pellet injection. A flexible Pellet Ablation Module (PAM), which predicts the density source based on a comprehensive analytical pellet ablation model, has been developed for predicting pellet fueling for transport studies, and has been incorporated into the STEP workflow for predictive modeling. This workflow is applied to DIII-D and finds good agreement with experiments. On ITER the effect of pellet fueling is examined in an advanced inductive scenario, where a fusion gain of up to Q = 9 is predicted with strong central pellet fueling. On CFETR, with a mid-radius density source, an average of

1.5
×

10

22

electrons s−1 are required to achieve the density and temperature profiles necessary for the 1000 MW advanced scenario with a tritium burn-up fraction of

∼

3
%

.
SpacePix2: SOI MAPS detector for space radiation monitoring
Authors: Vančura P. , Gečnuk J. , Janoška Z. , Jirsa J. , Korchak O. , Kostina A. , Kafka V. , Lednický D. , Marčišovská M. , Marčišovský M. , Švihra P. , Tomášek L. , Staněk P. 
Published: January 2023

Abstract
The SpacePix2 monolithic active pixel sensor (MAPS) is a novel ASIC for space radiation monitoring designed in a 180 nm SOI CMOS technology. The active sensor area is 3.84 × 3.84 mm2, pixel matrix is arranged as a 64 × 64 array with 60 µm pitch. The pixel front-end amplifier signal range is 2–80 ke−, extended up to 30 Me− using a backside channel. Diodes integrated in the handle wafer in each pixel are biased at −150 V. Impinging particle generates a charge pulse converted to voltage pulse by charge sensitive amplifier (CSA). Maximum voltage memorized by the peak detector hold (PDH) circuit is digitized using on-chip 10-bit asynchronous column SAR ADCs. Two readout interfaces are available, 400 MHz LVDS and 50 MHz SPI. Total power consumption is 43 mA from a 1.8 V power supply. The ASIC has been tested in space in low Earth orbit (LEO) and sample data are shown.