bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adherence to the AAP’s Institutional Ethics Committee Policy Recommendations
Authors: Weaver Meaghann S. , Ulrich Connie M. , Moon Margaret R. , Walter Jennifer K. 
Published: August 2023

OBJECTIVES
In 2019, the American Academy of Pediatrics (AAP) outlined 8 operational recommendations for pediatric institutional ethics committees (IECs). The study purpose was to quantify the extent to which pediatric IECs adhere to the AAP IEC Policy Statement recommendations.

METHODS
A convenience sample of ethics points of contact from Children’s Hospital Association membership were invited to complete an electronic survey on their ethics programs and practices in spring 2022. Nineteen survey questions were preidentified as reflecting measures specific to best practice standards previously published by the AAP. This subset of questions was analyzed using frequencies and categorized to assess for adherence to the AAP IEC policy recommendations.

RESULTS
A total of 117 out of 181 surveys were completed (65%). Stark IEC practice gaps include: lack of diversity of membership, training needs to maintain members’ competencies, quality improvement within the organization, and scope of ethics service. Over one-quarter of IECs do not have a systematic way of informing hospital staff about ethics consultancy services and how to place an ethics consult. Nineteen percent of responding IEC services do not inform patients or families about the existence of ethics consult services. One-third of responding children’s hospitals do not provide resources for the IECs to engage in ethics education at the facility.

CONCLUSIONS
IECs in children’s hospitals are not consistently abiding by operational recommendations. Next steps should include assessment of recommendation barriers and enablers with a goal of enhancing strong practices across IECs in children’s hospitals.
Renin-angiotenzin-aldoszteron-rendszer-gátlók fix gyógyszer-kombinációinak egyéves perzisztenciája hypertoniás betegekben
Authors: Simonyi Gábor , Ferenci Tamás , Finta Ervin , Medvegy Mihály , Wittmann István 
Published: August 2023

Bevezetés: Az európai és a hazai hypertoniaajánlásokban kiemelt
helyen szerepelnek a különböző hatóanyagok fix kombinációi. Az antihypertensiv
terápia első lépésének egy renin-angiotenzin-aldoszteron-rendszer-antagonistának
(RAAS-gátló) a kalciumcsatorna-blokkolókkal (CCB) vagy diuretikumokkal alkotott
fix kombinációit (FDC) javasolják. Célkitűzések: A szerzők
célja a RAAS-gátló FDC-k egyéves perzisztenciájának összehasonlítása volt
hypertonia indikációjában. Módszer: Az Országos
Egészségbiztosítási Pénztár vényforgalmi adataiból azokat a betegeket
választották ki a szerzők, akik a 2012. október 1. és 2013. szeptember 30.
közötti időszakban első alkalommal váltották ki bármely RAAS-gátló FDC-k
receptjeit, és akik a beválasztási időszakot megelőző egy évben nem váltottak ki
hasonló készítményeket. A perzisztencia modellezésére a túlélés-analízis
klasszikus eszköztárát alkalmazták, ahol a „túlélési” idő a gyógyszer szedésének
abbahagyásáig eltelt idő volt. Eredmények: A beválasztási
követelményeknek 443 149 beteg felelt meg. Az angiotenzinkonvertálóenzim-gátló
(ACE-gátló)/CCB FDC-k egyéves perzisztenciája 44,59%, az
angiotenzin-II-receptor-inhibitor (ARB)/tiazid diuretikum (HCT) FDC-k eredménye
42,52% volt, amelyet az ACE-gátló/indapamid FDC-k 37,27%-kal, az ARB/CCB FDC-k
29,04%-kal, az ACE-gátló/HCT FDC-k 27,47%-kal követtek. Az ACE-gátló/indapamid
FDC-hez (referencia) képest az ACE-gátló/CCB-k elhagyásának kockázata
31%-ponttal (HR = 0,69, 95% CI 0,6855–0,6996, p<0,0001), az ARB/HCT FDC-ké
18%-ponttal (HR = 0,82, 95% CI 0,8096–0,8267, p<0,0001) volt kedvezőbb, míg
az ACE-gátló/HCT FDC-ké 17%-ponttal (HR = 1,17, 95% CI 1,1562–1,1825,
p<0,0001), az ARB/CCB FDC-ké 20%-ponttal (HR = 1,20 95% CI 1,17316–1,2239,
p<0,0001) volt kedvezőtlenebb. A 360 napra korlátozott átlagos
gyógyszerszedési idő 239,9 nap volt az ACE-gátló/CCB FDC-k, 214,8 nap az ARB/HCT
FDC-k, 193,8 nap az ACE-gátló/indapamid FDC-k, 178,8 nap az ARB/CCB FDC-k és
177,6 nap az ACE-gátló/HCT FDC-k esetén. Következtetés: A
szerzők hypertoniás betegeken igazolták azt, hogy a RAAS-gátló FDC-k egyéves
perzisztenciája jelentős mértékben különbözik. A legelőnyösebbnek az
ACE-gátló/CCB FDC-k bizonyultak. Orv Hetil. 2023; 164(34): 1337–1341.
Diagnosis and treatment of sepsis-induced cardiomyopathy using hemosorption therapy: a case report
Authors: Dil S. V. , Kirilin V. V. , Ivanov N. M. , Ryabov V. V. 
Published: August 2023

Introduction. Sepsis is a life-threatening organ failure caused by the body’s dysregulated response to infection. The prevalence of sepsis-induced cardiomyopathy (SICM) in patients with sepsis ranges from 10 to 70%, while there are no special sections on SICM in the known resuscitation manuals. There is also a lack of large clinical trials evaluating the effectiveness of SICM treatment.Case. A 59-year-old patient was urgently hospitalized in the intensive care unit with shock of unknown origin. Emergency coronary angiography revealed no coronary obstruction. Two hours after admission, asystole was recorded with effective cardiopulmonary resuscitation, mechanical ventilation, infusion of inotropic and vasopressor drugs. The patient was diagnosed with leukocytosis up to 19*109/l, procalcitonin >0,5 ng/ml. Subsequently, stage 2 acute kidney injury, pneumonia, acute respiratory distress syndrome, sepsis, SICM, combined shock (cardiogenic, septic) were diagnosed. Antibiotic and hemosorption therapy using a CytoSorb column were started. On the 6th day, there was a improvement of hemodynamic parameters, a decrease in the rate of vasopressor infusion, and normalization of the left ventricular ejection fraction. The condition has stabilized with further favorable changes.Discussion. Despite the wide prevalence and high mortality in SICM, this condition is not well described in the literature, and there are no clear diagnostic criteria and treatment algorithms. This case demonstrates the effective treatment of SICM at the stage when the prognosis of patients becomes extremely unfavorable, reaching 90% mortality.Conclusion. This case demonstrates the effective treatment of SICM as an element of multiple organ failure, in the outcome of sepsis, using efferent methods, when the prognosis becomes extremely unfavorable. Personalized approach and management of these patients is critical to improve disease outcomes.
Features of brain magnetic resonance imaging (MRI) changes under the influence of renal denervation in patients with resistant hypertension
Authors: Lichikaki V. A. , Mordovin V. F. , Pekarskiy S. E. , Zyubanova I. V. , Manukyan M. A. , Solonskaya E. I. , Vtorushina A. A. , Khunkhinova S. A. , Sukhareva A. E. , Usov V. Yu. , Falkovskaya A. Yu. 
Published: August 2023

Aim. To study brain magnetic resonance imaging (MRI) changes in patients with resistant hypertension (HTN) after renal denervation (RD) and its cerebral protection effectiveness.Material and methods. The study included 111 patients, of whom 50 were men (45%) and 61 were women (55%), who underwent RD. The mean number of antihypertensive drugs taken regularly was 4,1±1,1. All patients underwent brain MRI and 24-hour ambulatory blood pressure monitoring before and after renal denervation. The data were statistically processed using Statistica 10,0 software.Results. After RD, a pronounced antihypertensive effect was observed with a significant reduction in systolic and diastolic blood pressure by 10,3/5,5 and 13,1/7,3 mm Hg at 6 and 12 months, respectively. Office blood pressure, daytime, and nighttime blood pressure levels also decreased (p<0,001). According to MRI data after RD, a decrease in the relative number of patients with I and II degree cerebrospinal fluid circulation changes and an increase in the proportion of patients without detected pathology were noted, but no significant difference in the obtained results was found. A decrease in the linear dimensions of brain ventricles was observed, including a reduction in the size of the left posterior horn of the lateral ventricle (p=0,03) and the third ventricle diameter (p=0,02) at 6 months after RD. At 12 months, the sizes of the anterior horn (p=0,04) and left lateral ventricle body (p=0,017) decreased. A positive effect of RD on the linear dimensions of cerebrospinal fluid system was noted, manifested by a decrease in the mean size of frontal subarachnoid spaces (p=0,028). No significant changes in the frequency and degree of focal lesions and lacunar infarcts were observed after RD (p>0,05).Conclusion. RD contributes to a significant decrease in blood pressure levels and exerts a cerebral protective effect by reducing lateral brain ventricles, subarachnoid spaces, and absence of ischemia progression and intracranial hypertension after intervention.
Biomarker Development, Methodological Challenges
Authors: Cutter Gary 
Published: August 2023

Biomarker development is a common endeavor in medical research. The purpose is to find indicators of disease occurrence or prognostic markers for response. The process of development of biomarkers often starts with showing mean differences between responders and non-responders or those with a disease or condition versus those without. However, these statistically significant mean differences, while necessary are not sufficient to validate a biomarker. Sensitivity, specificity, positive and negative predictive value are at least as important and the relative increase in performance using the biomarker over the usual clinical variables should be demonstrated. This paper discusses the various assessments in the context of use for the biomarker, the need for characteristics in addition to mean differences and the importance of independent validation of putative biomarkers. Lastly, it is hoped that the process and thoroughness be considered with recognition that the task is at best a difficult task.
Photography Museums in Turkiye on the 100th Anniversary of the Republic: Hamza Rüstem Photograph House and Museum
Authors: SEZER Işık 
Published: August 2023

Regardless of the field they focus on, museums provide tangible evidence of the technical and aesthetic development of human history. Through their chosen themes, visual object collections, and cognitive data, museums not only preserve the past but also facilitate connections with the present and envisioning the future. Invented in 1839, photography gained significant attention due to its power to rapidly record existing reality. The intersection of technology, chemistry, and physics led to the invention of the camera and image production, which continues to evolve today with its commercial success and artistic identity. Photography, an integral part of our social life, has created its own history since its invention. Therefore, collectors and museums consider it both a means of preservation and a central theme.
The first photography museum in the world was established in 1947. In Turkiye, in 1997, Hilmi Nakipoğlu's personal initiative transformed his camera collection into the first museum. Throughout Turkiye, there are six museums dedicated to photography equipment and cameras: Nakipoğlu Camera Museum, Balıkesir National Photography Museum, Osman Yaşar Tanaçan Photography Museum, Mysia Photography Museum, Malatya Metropolitan Municipality Camera Museum, and Hamza Rüstem Photography House and Museum. Additionally, the Ara Güler Museum was established to commemorate the photographer Ara Güler.
This article briefly discusses the concept of museums and examines photography museums in Turkiye, primarily focusing on the Hamza Rüstem Photography House and Museum. The Hamza Rüstem Photography House, which was established in 1925 and still operates in the same building, served as a school where the younger generation of photographers in Izmir received their training. In light of these characteristics, Hamza Rüstem, in commemoration of the 100th anniversary of the Republic, was discussed and portrayed through a conversation with his grandson, collector Mert Rüstem.
Hat Sanatında Özgür Yorum: Karalamalar
Authors: MEMİŞ Mehmet , İSEN Öznur 
Published: August 2023

Güzellik ve sanat iç içe geçmiş iki kavramdır. Bir bakıma güzellik, sanatın özüdür denilebilir. Her sanat dalında olduğu gibi hat sanatında da güzeli arama arzusu ve eşsiz eserler ortaya koyma çabası, hattatları sabırla çalışmaya ve kendi sınırlarını zorlamaya sevk etmiştir. Bir kitap sanatı olan hüsn-i hattın kelime manasının “güzel yazı” olmasına mukabil, daha iyisini yazmak uğruna harcanan çaba yorucu ve zahmetlidir, ancak sabırla çalışan elbette ki karşılığını alır. Başka bir deyişle “Muhakkak ki Allah güzeldir, güzeli sever!” hadis-i şerifi ışığında bu sanata gönül verenler, yazıyı daha muntazam yazma hususunda büyük ölçüde gayret gösterirler. Kişinin muntazam yazmayı başarması ise, sistematik çalışmasına bağlıdır. Yazıyı kaidelerine uygun ve ölçülü yazabilmek bıkmadan usanmadan, karamsarlığa kapılmadan çalışmakla mümkündür. Bu sebeple gerek öğrenme aşamasında ve gerekse sonrasında, harfler defalarca çalışma kâğıdına yazılarak el melekesi artırılır. Kelimeler ve harfler kâğıda kimi zaman noktalanıp ölçülendirilerek, kimi zaman da noktalanmadan yazılır. Talim amaçlı yapılan bu çalışmalar, başka bir deyişle karalamalar, hat sanatının temeli niteliğindedir.
Arap alfabesiyle yazılan ve “karalama” adı verilen el alıştırmaları yazıyla uğraşan kişinin o an irticalen elinden çıkan harf veya kelimelerden oluşur ve çoğu zaman bir anlam ifade etmez. Bu çalışmanın amacı, karalamaların estetik unsurlarını ele almak ve zaman içerisinde uğradığı değişime mercek tutmaktır. Hattatların bu özgür yorumları gün geçtikçe daha fazla önemsenmekte ve hayranlık uyandırmaktadır. Harf bünyesini oluşturan kaidelerin dışında satır ve sınırlara bağlı kalmadan yazılan bu yazılar kendi içinde bir kompozisyon oluşturmakta ve çoğu zaman yazan kişiyi dahi hayrete düşürecek özgün çalışmalar ortaya çıkabilmektedir.
Evaluation of fatty liver with grey scale 2D ultrasonography and ultrasound elastography and co-relation with lipid profile in adult patient in the state of Chhattisgarh attending Dr. Bhim Rao Ambedkar memorial hospital tertiary care centre Raipur
Authors: Chaudhari Ashwini Narayan 
Published: August 2023

Background: Several noninvasive imaging techniques have been introduced for the assessment of liver fibrosis. Among these techniques real-time Point shear wave elastography has become a promising imaging modality for the measurement of liver stiffness. The advantage of this technique is that the elasticity displayed using a B-mode image, also a quantitative estimation of liver stiffness is performed. The present study evaluates the fatty liver in patients above 18 years age with grey scale 2D ultrasonography and ultrasound elastography and also study the correlation with lipid profile in patients attending Dr B.R.A.M hospital tertiary care center Raipur, Chhattisgarh.
Methods: This was a hospital based observational study conducted in Department of Radio-diagnosis, Dr BRAM Hospital and Pt JNM Medical College, Raipur (C.G). A sample of 198 patient above 18-year age with fatty liver were taken. Grading and quantification of fatty liver was also done by Shear wave elastography. A p-value <0.05 was considered statistically significant.
Results: Mean age of study subjects was 48.47±15.21 years and 52.02% were female. 2D ultrasound technique diagnosed 75.25% grade-1 and 24.24% were in grade-II. Elastography technique diagnosed 57.58% with dysfunction (F1) liver stiffness, 28.28% fibrosis present (F2 or F3) and 13.64% normal. Increasing liver stiffness stages was significantly associated with increasing levels of serum VLDL (p=0.04).
Conclusions: Ultrasound used in conjunction with elastography has shown utility in diagnosing and follow up of fatty liver patients. Liver stiffness was significantly associated with increasing levels of serum VLDL.
Orif of lateral Hoffa's fracture with irreducible patella dislocation and incarcerated patella in lateral Hoffa's fragment: rare injury presentation
Authors: Lingayat M. B. , Bansode Prashant Rajkumar , Jadhav Aditya Vijaykumar 
Published: August 2023

Majority of lateral Hoffa fracture are associated with knee injury. Presenting a case of 30-years-old gentleman who presented with pain, swelling, deformity in knee of right side after road traffic accident. On local examination there was marked swelling with inability to palpate patella, inability to flex knee. On clinical examination, there was patella dislocation as it was not in place and unable to reduce. Radiological investigation showed a lateral Hoffa's fracture with dislocation of patella and patella being incarcerated in Hoffa fragment. Operative and follow up: Patient was operated by open reduction of patella dislocation and CC screw fixation for lateral Hoffa fracture. On six weeks follow up normal ROM achieved. Patient was surgically treated to relocate locked patella fragment in Hoffa's fragment and fix Hoffa's fragment and achieved good range of motion.
Formação de Professores e Educação de Jovens e Adultos: uma análise de cursos de Licenciatura em Química de instituições federais do Rio de Janeiro
Authors: Oliveira Junior Jardel Silva , Augustinho Elizabeth , Silva Andrea Moraes 
Published: August 2023

When discussing the exercise of teaching in basic education, the arguments linked to the specificities of early childhood education, elementary school and high school are expressive, as well as the language adaptations that must occur at each stage. EJA also requires the same premises of this debate, requiring exclusive training for teachers working in this modality. The main objective of this study is to analyze how the Licentiate Degree courses in Chemistry at the federal institutions IFRJ and UFRJ have prepared graduates to work in EJA. This research, of a qualitative nature, was developed from a bibliographic review and a documental analysis. For this, a theoretical explanation was made regarding the training of teachers for EJA, in addition to dedicating part of the work to specifically address the training of Chemistry teachers. Subsequently, disciplines aimed at education and teaching of Chemistry at the aforementioned institutions were researched and categorized. Then, having as a reference the Pedagogical Projects of the Courses and their curricular matrices, the syllabi of these disciplines were analyzed, seeking to verify how EJA has been contemplated in these degrees. As a result, it was concluded that advances in relation to the inclusion of studies on EJA in undergraduate courses are slow, through the offer of optional subjects for EJA.
Complementarities in Production and Trade between ASEAN Countries and India
Authors: Kaur Sandeep , Deepika - 
Published: August 2023

The share of Indiaâ€™s export to WANA (West Asia and North Africa) is 22.5 percent, followed by EU (European Union) 21.2 percent and North America 15.5 Percent, ASEAN (Association of South East Asian Nations) 10.3 percent, South Asia 4.6 percent and Latin America 3.3 percent (Government of India, Economic survey 2010-11). As compared to other blocs (WANA, North America and EU) the share of Indiaâ€™s exports to ASEAN is low. Thus there is need to examine the reasons for low trade of India with ASEAN nations.Â In the light of this, the present paper has been undertaken to study competitiveness or complementarities in production and trade among India and ASEAN nations and to study the pattern of intra -regional trade of ASEAN nations. There is substantial range of existing complementarities between ASEAN and India. As most of the ASEAN countries are heavily dependent on imported drugs and health care equipments, therefore India could also cooperate with ASEAN in pharmaceutical and health care service sectors. India Shares Sea boundaries with three ASEAN countries namely Indonesia, Myanmar and Thailand. Thus in terms of transport cost, India has benefit to trade with ASEAN. So, India should look at expanding sea transport linkages to promote trade, tourism and other economic activities.
Offshore Financial Centers: Recent Evolution and Likely Future Trends
Authors: SantillÃ¡n-Salgado Roberto J. 
Published: August 2023

The origins of the world-wide distributed Offshore Financial Centers are related to the surge of the Eurocurrency markets during the 1950s and 1960s. After a first stage of rapid expansion, many of those OFCs reached a consolidation stage and remained, even after most of the original drivers for their creation were no longer present. Their insertion as part of the complex mechanisms of the global financial markets is driven byÂ the high skilled financial services as well as the usually benign fiscal treatment the host countries give to multinational institutions established in their territory. As a consequence of the 2007-2009 Financial Crisis, the more advanced nations have formed a new group called the G20, with the aim to improve the coordination of different dimensions of the international economic environment. In its first reunions the G20 have focused in discussing the changes that are needed at the level of the financial architecture and the regulations that apply to international financial markets, with the intention to minimize the probability of another episode of financial crisis in the future. The changes that are likely to follow the G20 initiatives will change the operating conditions and affect the competitive advantages of the OFCs, but will also represent new opportunities for business. This work briefly explores the historical background of the OFCs phenomenon, analyzes its current situation and discusses its likely future trends, based on the OFCsâ€™ most recent environmental changes.