bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE MMP9 −1562 C/T POLYMORPHISM IS ASSOCIATED WITH INCREASED RISK OF DIABETIC RETINOPATHY IN TURKISH TYPE 2 DIABETES MELLITUS PATIENTS
Authors: MUTLU İÇDUYGU Fadime , AKGÜN Egemen , ALP Ebru , DOĞUİZİ Sibel , ÖZER Murat Atabey 
Published: June 2023

Objective
Type 2 diabetes mellitus (T2DM) and diabetic
retinopathy (DR) development is affected by genetic
factors. Matrix metalloproteinases (MMPs) are involved
in many cellular processes, such as remodeling of
extracellular matrix proteins and angiogenesis. In
this study, we investigated the relationship between
MMP9 −1562 C/T (rs3918242) polymorphism and the
development of T2DM and DR in Turkish population.
Material and Method
A total of 510 participants, involving 168 T2DM
cases with DR, 168 T2DM cases without DR,
and 174 controls, were included in the study. The
polymerase chain reaction-restriction fragment length
polymorphism (PCR-RFLP) method was carried out
to identify genotypes.
Results
The CT, CT+TT genotypes and the T allele of the
MMP9 −1562 C/T polymorphism were associated with
increased risk of DR (p=0.001). On the other hand,
no relationship was found between the development
of T2DM and this polymorphism. In addition,
CT (p=0.010) and CT+TT (p=0.015) genotype
frequencies were found to be higher in proliferative
diabetic retinopathy (PDR) cases compared to nonproliferative
diabetic retinopathy (NPDR) cases, but
after regression analysis, only insulin use (p=0.003)
was found to be associated with the development of
PDR.
Conclusion
Our data show that the MMP9 −1562 C/T polymorphism
is associated with the development of DR in Turkish
T2DM patients, but no significant relationship was
found between this polymorphism and the severity of
DR and the development of T2DM.
The potential of Muslim Friendly Hospitality in the tourism industry in Central Java
Authors: Iskandar Iskandar , Waridin Waridin , Iskandar Deden Dinar 
Published: June 2023

This study aims to identify Muslim hospitality potential in the Central Java tourism industry. This research uses a hybrid research method or a Multiphase Mixed Method. Multiphase data were collected simultaneously between qualitative and quantitative data. Data were taken from literature studies, field observations, and in-depth interviews with key informants. The analytical methods used in this study included the Mic-Mac and Mactor analytical instruments, descriptive statistics, and Triangulation Methods. Results of the study show that although Central Java has not applied MFH regulations, the halal tourism industry is practiced in tourism. Central Java has all the potential for Muslim Hospitality with a score of 3.8 out of 5 based on the Indonesian Muslim Travel Index (IMTI) category. The potential for various scenic destinations, polite manner of community, stable and safe political conditions, financial institutions’ support, the existence of Islamic boarding schools, and both tangible and intangible Islamic historical heritage are all the strengths of MFH in Central Java. The theoretical implication of this research can be used as a starting point for further research. Whereas the applied implication suggests that the government needs a seed to immediately formulate regulations on Halal Tourism as affirmed by the state.
PERCEIVED PROCEDURAL AND ORGANIZATIONNAL COMMITMENT OF HIGHER EDUCATION TEACHERS IN CAMEROON: THE CASE OF TEACHERS AT THE UNIVERSITY OF DSCHANG
Authors: Lexline Lynda Tankeu Chimi 
Published: June 2023

Cette étude a examiné le lien entre la justice procédurale perçue et l'engagement organisationnel des enseignants de l'Université de Dschang dans l'ouest du Cameroun. Elle était guidée par la théorie de l'échange social de Blau (1964). A l'aide d'un questionnaire, des données ont été recueillies auprès de cent cinq (105) enseignants de différentes facultés de l'Université de Dschang. Cependant, quatre-vingt-onze (91) questionnaires ont été utilisés dans l'analyse, en raison de chiffres incomplets et manquants dans d'autres questionnaires. La fiabilité du questionnaire a été testée à l'aide de la technique Alpha de Crombach avec des coefficients de 0,90 et 0,80 respectivement pour la justice procédurale et l'engagement organisationnel. Le traitement statistique a été effectué à l'aide du logiciel statistique SPSS version 23. Des analyses descriptives et des tests de corrélations ont été effectués.r= 0,378 ; p < .01). Il n'y a pas de lien significatif entre la justice procédurale et l'engagement normatif ( r= .161 ; p> .05). Cependant, l'existence d'un lien négatif et significatif a été établie entre la perception de la justice procédurale et l'engagement calculé ( r= .-234 ; p< .05). Il a été recommandé que les institutions, les policiers et les employés s'assurent que les applications des procédures de distribution des récompenses soient les mêmes pour tous les employés de l'organisation afin de stimuler leur engagement organisationnel.
Yeni Bir Kalp Cerrahi Merkezi: Konya Şehir Hastanesinde Açık Kalp Cerrahisi Deneyimlerimiz
Authors: ÇİÇEK Mustafa Cüneyt , DAĞLI Mustafa , BAYSAL A Nihat , BARBARUS Emin , GÖKMENGİL Hayat , DURMAZ Hüseyin , YILMAZ İlyas Selim , GÜNERHAN Yalçın , DURGUT Kadir 
Published: June 2023

Amaç: Bu çalışmanın amacı, yeni bir merkez olan Konya Şehir Hastanesi'nde 2020 yılından bu yana gerçekleştirilen açık kalp cerrahisi tecrübelerinin değerlendirilmesidir.
Gereç ve Yöntemler: Konya Şehir Hastanesi Kalp ve Damar Cerrahisi Kliniği’nde Ağustos 2020 ile Mayıs 2022 tarihleri arasında gerçekleştirilen toplam 232 açık kalp ameliyatı retrospektif olarak değerlendirilmiştir. Tüm vakalarda median sternotomi ile operasyon gerçekleştirilmiştir. Hastaların kayıtlarına hastane sisteminden ulaşılmıştır.
Bulgular: Çalışmaya dahil edilen hastaların yaş ortalaması 60,79±10,4 yıl olarak belirlenmiştir. Hastaların preoperatif risk skorlamasında EuroSCORE II sistemi kullanılmış ve 78 hastada düşük risk, 64 hastada orta risk ve 90 hastada yüksek risk saptanmıştır. Açık kalp cerrahisi operasyonları içinde en sık yapılan işlem koroner arter baypas operasyonudur (n=190, %81,89). Postoperatif dönemde en sık görülen komplikasyon atrial fibrilasyon (n=34, %14,65) olup kanama nedeniyle 16 (%6,89) hasta revizyona alınmıştır. On bir (%4,74) hastada ise postoperatif erken dönemde mortalite saptanmıştır.
Sonuçlar: Yeni kurulan bir merkez olmakla birlikte bu çalışmada gerek vaka sayısı ve çeşitliliği gerekse düşük mortalite ve morbidite oranları ile kliniğimizde yapılmış olan açık kalp ameliyatlarının sonuçlarının literatür ile uyumlu olduğu gösterilmiştir.
POST-BELGESEL FOTOĞRAFTA GERÇEKLİK TARTIŞMALARI VE SPEKÜLATİF BELGESEL FOTOĞRAF
Authors: DAYI Handan 
Published: June 2023

Fotoğraf doğası gereği gerçeklik kavramıyla hep yakın ilişki içerisinde olmuş, özellikle belgesel fotoğraf
gerçekliğin yansıması olarak görülmüştür. Ancak post-modern eleştirmenler belgesel fotoğrafın gerçeklikle
kurduğu ilişkiye eleştiriler getirmişlerdir. Makale, bu eleştirilerin yanı sıra, gerçeklik kavramının çağdaş
felsefedeki değişimlerine de odaklanmaktadır. Nesne Yönelimli Ontoloji ve Spekülatif Gerçekçilik olarak
adlandırılan bu yeni felsefi düşünceler, insanı merkeze almayan “gerçekçi” bir tutumun mümkün olduğunu
söylemektedir. Özellikle Graham Harman’ın Nesne Yönelimli Ontolojide sanat üzerinden yaptığı açıklamaların,
belgesel fotoğraf alanındaki gerçeklik tartışmalarına da yeni açılımlar sağlayacağı düşünülmektedir.
Max Pinckers’ın kurduğu, Spekülatif Belgesel Okulu, Harman’ın nesne yönelimli felsefesindeki gerçeklik
tartışmalarına benzer bir vurgu yapar. Post belgesel içerisinde sınıflandırılan spekülatif belgesel fotoğrafın,
belgesel ve kurgunun hibrit ilişkisini vurgulayan manifestolarıyla belgesel fotoğrafta yeni tartışmalar yaratacağı
düşünülmektedir. Bu makalede Spekülatif Realizm ve Nesne Yönelimli Ontoloji felsefesine değinilecek,
spekülatif belgesel fotoğrafın tanımı, önemi aktarılacak ve yeni felsefelere olan yakınlığı da araştırılacaktır.
Assessing the effects of population-level political, economic and social exposures, interventions and policies on inclusive economy outcomes for health equity in high income countries: A systematic review of reviews
Authors: Macintyre Anna K , Shipton Deborah , Sarica Shifa , Scobie Greame , Craig Neil , McCartney Gerry 
Published: June 2023

Abstract
Background
A fairer economy is increasingly recognised as crucial for tackling widening social, economic and health inequalities within society. However, which actions have been evaluated for their impact on inclusive economy outcomes is yet unknown.
Objective
Identify the effects of political, economic and social exposures, interventions and policies on inclusive economy (IE) outcomes in high-income countries, by systematically reviewing the review-level evidence.
Methods
We conducted a review of reviews, searching databases (May 2020) EconLit, Web of Science, Sociological Abstracts, ASSIA, International Bibliography of the Social Sciences, Public Health Database, Embase and Medline; registries PROSPERO, Campbell Collaboration and EPPI Centre (February 2021) and grey literature (August/September 2020). We aimed to identify reviews which examined social, political and/or economic exposures, interventions and policies in relation to two IE outcome domains: (i) equitable distribution of the benefits of the economy and (ii) equitable access to the resources needed to participate in the economy. Reviews had to include primary studies which compared IE outcomes within or between groups. Quality was assessed using a modified version of AMSTAR-2 and data synthesised informed by SWiM principles.
Results
We identified 19 reviews for inclusion, most of which were low quality, as was the underlying primary evidence. Most reviews (n = 14) had outcomes relating to the benefits of the economy (rather than access to resources) and examined a limited set of interventions; primarily active labour market programmes and social security. There was limited high-quality review evidence to draw upon to identify effects on IE outcomes. Most reviews focused on disadvantaged groups and did not consider equity impacts.
Conclusions
Review-level evidence is sparse and focuses on ‘corrective’ approaches. Future reviews should examine a diverse set of ‘upstream’ actions intended to be inclusive ‘by design’, and consider a wider range of outcomes, with particular attention to socioeconomic inequalities.
Ab Initio Calculations on Structure and Stability of BN/CC Isosterism in Azulene
Authors: Abdel-Rahman Mohamed A. , Soliman Kamal A. , Abdel-Azeim Safwat , El-Nahas Ahmed M. , Taketsugu Tetsuya , Nakajima Takahito , El-Meligy Asmaa B. 
Published: June 2023

Abstract
Herein, we investigated the thermodynamics stability and the opto-electronic properties of newly BN-doped azulene. The gas-phase formation enthalpies of 11 BN-doped azulene were calculated by the atomization energy method using three computational models, CBS-APNO, CBS-QB3, and G3MP2. The results indicate that AZ-1N9B is the most stable isomer, while AZ-1B9N and AZ-9B10N display almost the same stability (relative energies of 19.36 and 19.82 kcal/mol at CBS-QB3, respectively), representing the two least stable isomers. Frontier molecular orbitals (FMO), ionization energies (IE), and electron affinities (EA) of these isomers were discussed. The electronic absorption spectra of the BN-doped azulenes were calculated at the TD-B3LYP/6-31+G(d,p) and TD-CAM-B3LYP as a long-range corrected hybrid functional in acetone. The obtained computational results are in strong harmony with the literature which enhances our results.
Impacts of changing climate and topography on snow cover variability of Parvati River Basin, western Himalayas, India
Authors: KUMAR DEEPAK , Thind Parteek Singh , Sharma Tejpal 
Published: June 2023

Abstract
Snow cover is an essential element of the Himalayan region (Third pole), and it represents the impacts induced by climate change. Recently, studies have reported significant variation in Himalayan snow cover area which may impact the livelihood of large portion of global population. Therefore, in this study efforts were made to estimate the association between key climate stressors (CSs) i.e., temperature and precipitation, topography and temporal variability of snow cover area (SCA) in the Parvati River basin (PRB) of the Indian western Himalayas. In this regard, the PRB was classified into different elevation zones i.e., zone I to zone V, ranging from 1100 masl to 6200 masl. The databases such as, MODIS, MEERA-2, and ASTER GDEM V2 were used to estimate the changes in the SCA and the CSs with changes in elevation and seasons. The linear regression analysis of the dataset, from 2001 to 2017, revealed a significant association and increasing trend in the SCA of the zone III. However, a significant association could not be established between the elevation and the SCA for the rest of the zones. Zonal seasonal trend investigation of the SCA observed increasing trend in zone IV and zone V, during the summer season due to momentous rise in snowfall and decline in temperature. The SCA showed significant declining trend only during the monsoon season in zone IV and V which was due to a strong negative relationship between the SCA and temperature of the region. This demonstrates that the amount of SCA in zones of high elevation of the PRB has been declining at an alarming rate which could negatively influence glaciers’ retreat in the near future. Hence, it can be estimated that the outcomes of the study will act as a base literature for future studies, regional policy formulation and climate modelling, that can further prevent future drastic/extreme events.
Epidemiological characterization of hormonal receptor profiles and associated histopathological characteristics in Rwandan women with breast cancer: a retrospective study
Authors: Musanabaganwa Clarisse , Ruton Hinda , Ruhangaza Deogratias , Nsabimana Nicaise , Kayitare Emmanuel , Muvunyi Thierry Zawadi , Semakula Muhammed , Ntirenganya Faustin , Emile Musoni , Ndoli Jules , Hategekimana Elisee , Nassir Angus , Makhoha Francis , Uwimana Aline , Gasana Joel , Munezero Pierre Celestin , Nyirazinyoye Laetitia , Muvunyi Claude Mambo , Mazarati Jean Baptiste , Mutesa Leon 
Published: June 2023

Abstract
Background Breast cancer is the most common cancer in women worldwide and the second leading cause of cancer mortality in Rwanda. The knowledge of hormonal receptors and Human Epidermal growth factor Receptor -2 (Her-2/Neu) profile remains crucial in the management of breast cancer, even in this –omics era. However, Immunohistochemistry staining and practice remains scarce in many hospital settings, especially in LMICS including Rwanda. This study aimed at determining the distribution of breast cancer molecular subtypes, and associated clinical outcome in Rwandan women. Methodology This study combined method consisting of an initial hospital-based epidemiological retrospective design to document the epidemiological data for breast cancer patients in Rwanda from January 2014 to June 2021. Records of patients with confirmed breast cancer were documented from 4 cancer centers of excellence in Rwanda.
Results A high number of participants expressed estrogen receptor positive (55.6%) and HER2 was the lowest expressed receptor (33.1%). The triple negative breast cancer (TNBC) was more prevalent (37%), followed by luminal A (26%), HER2-enriched (24%) and luminal B (13%). These subtypes were found significantly different with regards to menopausal status, histological grades and hormonal therapy (p<0.0001).
Conclusion This study revealed that patients who got treatment, especially hormonal therapy have much more chances of living than those who haven’t gone under treatment. Moreover, aggressive histological type and grade were also overexpressed. These suggest the introduction of other targeted therapies, and inclusion of ‘omic’ technologies necessary to individual characteristics of molecular landscape to manage breast cancer patients, especially TNBC patients. Future research on genetic characterization using genomic sequencing will shed light on the associated variant genes for breast cancer personalized medicine.
Simulation and experimental study of a magnetorheological clutch in driving power generation
Authors: Ji Jinjie , Shi Xiuwei , Xu Chunjie , Xie Fangwei , Tian Zuzhi , Li Yongjie 
Published: June 2023

Abstract
The torque to volume ratio and time response characteristics of the clutch during vehicle travel power generation are important issues that affect the quality and efficiency of power generation. In this work, a magnetorheological clutch was established based on the magnetorheological effect and analyzed its magnetic field strength, maximum output torque, time response characteristics, and temperature rise characteristics in driving power generation. The results indicate that the maximum torque of 77.05 N·m is only 3.68% less than the designed value. MR clutches have a better torque to volume ratio for the same volume. The MR clutch can realize millisecond regulation of power output characteristics, the response time of the torque loading section is about 345 ms, while the response time of the torque withdrawal section is about 680 ms. The MR clutch has good heat dissipation performance with an external water-cooling device. Using an MR clutch as a governor for traveling vehicle power generation, the time-varying engine speed is converted to a constant speed by continuously adjusting the excitation current, which can provide more efficient power generation.
Determinants of Unmet Need for Family Planning Among Currently Married Reproductive Age Women at Dewa Chefa District of Oromia Special Zone, Amhara Region, Ethiopia, 2021; A Case-Control Study
Authors: Mohammed Mohammed Ammie , Temesgen Mastewal Arefaynie , Desta Bezawit Adane , Mohammed Kedir Hussein , Sero Mohammedsani Hassen 
Published: June 2023

Abstract

Background
Unmet need for family planning is a proportion of women among reproductive age group who want to stop or delay childbearing but are not using any method of contraception. An estimated 23 million reproductive age women have an unmet need for modern contraception. Thus, understanding factors associated with unmet need specific to the study area can help planners strengthen programs. Most of studies conducted previously are cross sectional and there are controversies between studies. Thus, this study aimed to identify determinants of unmet need for family planning among currently married reproductive age women of Dewa Chefa district.
Methods
Community based unmatched case control study was conducted from March 29-April 25, 2021 G.C on 462 currently married reproductive age women (154 cases and 308 controls) in Dewa Chefa District. A structured and pre-tested questionnaire was used to collect data. Collected data were entered to Epi-data 3.1 and exported to SPSS 23 for analysis. Binary Logistic regression was conducted to identify factors associated with unmet need and variables with p-value < 0.05 in the final model were taken as statistically significant.
Results
A total of 462 subjects had participated in this study, with 100% response rate. The mean age of the respondents was 27.92 years (with SD of ± 6.3) Age of woman 35–49 [AOR = 6.6 (1.1–39)], having poor knowledge on FP [AOR = 1.9 (1.1–3.1)], using FP decided by husband [AOR = 3.8 (2.1–6.9)], using FP decided together [AOR = 2.3 (1.07–5.1)] and have no support and disapproval of husband for FP use [AOR = 2.1 (1.08-4)] were factors significantly associated with unmet need.
Conclusion and Recommendations
Age of the woman and main decider of FP use were found to have positive significant association, while having knowledge about FP and support and approval of spouse for FP use were found to have negative significant association with unmet need for FP. Thus, family planning providers, District health office and other concerned bodies should more strengthen female empowerment and male involvement in the program with strong couple counseling to reduce unmet need.
Digital Inclusive Finance, Government Intervention and Urban Green Technology Innovation
Authors: Wang Min , Song Wenhua , Qi Xiao 
Published: June 2023

Abstract
Digital inclusive finance eases credit constraints on innovative small and medium-sized enterprises which contributes to urban green technology innovation in China. Government intervention plays an essential role in the development of digital inclusive finance. Based on the panel data of 247 cities in China from 2011 to 2019, this paper empirically examines the relationship between digital inclusive finance and urban green technology innovation as well as the intrinsic mechanism of government intervention. The findings show that, even after a series of robustness tests, digital inclusive finance can promote the quantity and quality of green technology innovation. In terms of its mechanism, digital inclusive finance can empower green technology innovation by complementing traditional financial development and stimulating consumption, both in terms of supply and demand. At the same time, in the dynamic process of digital financial inclusion from low to high, the development of traditional finance and consumption level on the marginal promotion of green technology innovation continues to strengthen. The nonlinear relationship test reveals that there is a significant double threshold effect on the positive impact of digital inclusive finance on urban green technology innovation with the evolution of government intervention. The innovation incentive effect of digital financial inclusion will be marginal decreasing with the increase of government intervention. Further considering the heterogeneity of urban geographic location and environmental regulation, it is found that digital financial inclusion promotes green technology innovation more in eastern and high-environmental regulation cities. Based on the above research conclusions, this paper argues that while developing digital inclusion finance, government support policies should be adjusted promptly to constantly stimulate the "Metcalfe's law" effect of digital inclusive finance enabling green technology innovation.
A survey to assess the current status of structured Benefit-Risk assessment in the global drug and medical device industry
Authors: Gebel Martin , Renz Cheryl , Rodriguez Lisa , Simonetti Arianna , Yang Hong , Edwards Brian , Higginson James Matthew , Charpentier Nicola , Colopy Michael 
Published: June 2023

Abstract

Background
This industry survey was conducted to gain insight into the ways structured Benefit-Risk assessment (sBRA) of medical products is approached across drug or medical device developing companies, including frameworks and methods that are currently used and areas where future work is being planned.
Methods
A survey containing 28 questions covering five key areas of sBRA was set-up and shared with representatives from the participating companies. Each company was asked to complete a single survey response including inputs across the company’s multidisciplinary key representatives involved in benefit-risk assessment.
Results
Of the 26 participating companies, 21 are conducting sBRA. Qualitative frameworks were used by almost every company (19), while only 12 have used a quantitative method. Many companies have sBRA training (17), document templates (16), Standard Operating Procedures (SOPs)/checklists (13), and /or best practice manuals/examples (12) available. Software tools (15/26) and BR planning documents (11/26) were identified as areas into which many companies intend to put effort.
Conclusions
The industry survey confirmed a wide usage of sBRA by many companies involved in research and development. Nevertheless, sBRA is evolving and several future opportunities like the implementation of visualization tools were identified by the representatives of the pharmaceutical companies. Finally, challenges like the cross-functional comprehension of the added value of sBRA are still seen.