bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine Learning–Based Cloud Forecast Corrections for Fusions of Numerical Weather Prediction Model and Satellite Data
Authors: Nguyen Chuyen , Nachamkin Jason E. , Sidoti David , Gull Jacob , Bienkowski Adam , Bankert Rich , Surratt Melinda 
Published: June 2023

Abstract
Given the diversity of cloud-forcing mechanisms, it is difficult to classify and characterize all cloud types through the depth of a specific troposphere. Importantly, different cloud families often coexist even at the same atmospheric level. The Naval Research Laboratory (NRL) is developing machine learning–based cloud forecast models to fuse numerical weather prediction model and satellite data. These models were built for the dual purpose of understanding numerical weather prediction model error trends as well as improving the accuracy and sensitivity of the forecasts. The framework implements a UNet convolutional neural network (UNet-CNN) with features extracted from clouds observed by the Geostationary Operational Environmental Satellite-16 (GOES-16) as well as clouds predicted by the Coupled Ocean–Atmosphere Mesoscale Prediction System (COAMPS). The fundamental idea behind this novel framework is the application of UNet-CNN for separate variable sets extracted from GOES-16 and COAMPS to characterize and predict broad families of clouds that share similar physical characteristics. A quantitative assessment and evaluation based on an independent dataset for upper-tropospheric (high) clouds suggests that UNet-CNN models capture the complexity and error trends of combined data from GOES-16 and COAMPS, and also improve forecast accuracy and sensitivity for different lead time forecasts (3–12 h). This paper includes an overview of the machine learning frameworks as well as an illustrative example of their application and a comparative assessment of results for upper-tropospheric clouds.

Significance Statement
Clouds are difficult to forecast because they require, in addition to spatial location, accurate height, depth, and cloud type. Satellite imagery is useful for verifying geographical location but is limited by 2D technology. Multiple cloud types can coexist at various heights within the same pixel. In this situation, cloud/no cloud verification does not convey much information about why the forecast went wrong. Sorting clouds by physical attributes such as cloud-top height, atmospheric stability, and cloud thickness contributes to a better understanding since very different physical mechanisms produce various types of clouds. Using a fusion of numerical model outputs and GOES-16 observations, we derive variables related to atmospheric conditions that form and move the clouds for our machine learning–based cloud forecast. The resulting verification over the U.S. mid-Atlantic region revealed our machine learning–based cloud forecast corrects systematic errors associated with high atmospheric clouds and provides accurate and consistent cloud forecasts from 3 to 12 h lead times.
Climatology of Tropical Cyclone Rainfall Magnitude at Different Landfalling Stages: An Emphasis on After-Landfall Rain
Authors: Guzman Oscar , Jiang Haiyan 
Published: June 2023

Abstract
Estimating the magnitude of tropical cyclone (TC) rainfall at different landfalling stages is an important aspect of the TC forecast that directly affects the level of response from emergency managers. In this study, a climatology of the TC rainfall magnitude as a function of the location of the TC centers within distance intervals from the coast and the percentage of the raining area over the land is presented on a global scale. A total of 1834 TCs in the period from 2000 until 2019 are analyzed using satellite information to characterize the precipitation magnitude, volumetric rain, rainfall area, and axial-symmetric properties within the proposed landfalling categories, with an emphasis on the postlandfall stages. We found that TCs experience rainfall maxima in regions adjacent to the coast when more than 50% of their rainfall area is over the water. TC rainfall is also analyzed over the entire TC extent and the portion over land. When the total extent is considered, rainfall intensity, volumetric rain, and rainfall area increase with wind speed intensity. However, once it is quantified over the land only, we found that rainfall intensity exhibits a nearly perfect inversely proportional relation with the increase in TC rainfall area. In addition, when a TC with life maximum intensity of a major hurricane makes landfall as a tropical depression or tropical storm, it usually produces the largest spatial extent and the highest volumetric rain.

Significant Statement
This study aims to describe the cycle of tropical cyclone (TC) precipitation magnitude through a new approach that defines the landfall categories as a function of the percentage of the TC precipitating area over the land and ocean, along with the location of the TC centers within distance intervals from the coast. Our central hypothesis is that TC rainfall should exhibit distinct features in the long-term satellite time series for each of the proposed stages. We particularly focused on the overland events due to their effects on human activities, finding that the TCs that at some point of their life cycle reached major hurricane strength and made landfall as a tropical storm or tropical depression produced the highest volumetric rain over the land surface. This research also presents key observational evidence of the relationship between the rain rate, raining area, and volumetric rain for landfalling TCs.
Evaluating the Precipitation Biases over the Western Periphery of the Sichuan Basin with the ECMWF Operational Forecast Model
Authors: Li Juan , Chen Haoming , Li Puxi , Jiang Xingwen 
Published: June 2023

Abstract
Based on the hourly merged precipitation product, the performance of the European Centre for Medium-Range Weather Forecasts (ECMWF) Integrated Forecasting System (IFS) in simulating the diurnal variations of precipitation during warm season over the western periphery of the Sichuan basin (SCB) has been evaluated, and the underlying physical causes associated with the wet biases have also been investigated. The results show that the IFS well reproduces the spatial distributions of precipitation amount, frequency, and intensity over the SCB, as well as their diurnal variations, but the simulated precipitation peaks earlier than the observation with notable wet biases over the western periphery of the SCB. In addition, the strong wet biases exhibit notable regional differences over the western periphery of the SCB. The simulated wet biases over the southwestern periphery of the SCB expand westward to higher altitudes along the windward slope, with the maximum wet biases occurring at night. The westward expansion of the simulated stronger upward motions results in a westward shift of precipitation. However, the simulated precipitation over the northwestern periphery of the SCB has small difference in terms of the location; hence, the overestimated precipitation is associated with the stronger atmospheric instability, resulting from the higher potential temperature and the larger specific humidity near the surface. The findings revealed in this study indicate that the ECMWF forecast shows distinct uncertainties over the different complex terrain, and thus offers a promising way forward for improvements of model physical processes.
Unravelling the Roots of Emotional Development: Examining the Relationships Between Attachment, Resilience and Coping in Young Adolescents
Authors: Godor Brian P. , van der Horst Frank C. P. , Van der Hallen Ruth 
Published: June 2023

One’s attachment style forms early in life and can aid in dealing with future setbacks. Equally, Coping and resilience are two specific psychological mechanisms that form how one deals with problems and recovers from stressful situations. These three concepts are well-known interrelated concepts within psychology but to what extent they overlap is still unclear. The present study investigated attachment, resiliency and coping using structural equation modeling. Participants ( N = 390), aged between 9 and 12 y old, completed an paper survey including Experiences in Close Relationship-Revised questionnaire (ECR-RC-12), Resiliency Scales for Children & Adolescents (RSCA), and the Brief-CPE (Coping Orientation to Problems Experienced). Path analysis revealed strong associations between attachment and resiliency as well as strong associations between resiliency and coping. Specifically, the predictive value of anxious attachment on resiliency was seen for all three resiliency sub-scales. However, the predictive value of avoidance attachment on resiliency was only revealed for two of the resiliency sub-scales. The two resiliency protective factors (sense of mastery and sense of relatedness) have a positive predictive value for three coping strategies. Equally, the resiliency risk factor (emotional reactivity) also positively predicted two coping strategies. The current findings demonstrate clear associations between these three concepts. Equally, the theoretical connections are discussed in light of these findings. Equally, stemming from this study, clinical implications are discussed that can inform practice in terms of approaching psychopathologies from different angles (resilience, coping, and attachment) as well as, the development of coping and resilience skills in order to support healthy development.
Adverse effects of copper, manganese and mercury, alone and in mixtures on the aorta and heart of Spraque-Dawley rats
Authors: Janse van Rensburg M , Bester MJ , van Rooy MJ , Oberholzer HM 
Published: June 2023

Cardiovascular diseases (CVD) are a common global cause of death and are therefore a major health concern. Inhaled or ingested environmental heavy metals contribute to the development of CVD. The aim of this study was to address the limited information available on the effect of relevant dosages of metals in mixtures. Three metals with reported effects on the cardiovascular system (CVS) were identified, and these metals were copper (Cu), manganese (Mn) and mercury (Hg). In Sprague-Dawley rats, the adverse effects of copper (Cu), manganese (Mn) and mercury (Hg), alone and as part of mixtures, on the blood parameters, the aorta and heart were investigated. Forty-eight male Sprague-Dawley rats were randomly divided into eight groups ( n = 6): control, Cu, Mn, Hg, Cu + Mn, Cu + Hg, Mn + Hg and Cu, Mn + Hg. The seven experimental groups received the metal mixtures at 100 times the World Health Organisation (WHO) safety limit for drinking water (2 mg/L for Cu, 0.4 mg/L for Mn and 0.06 mg/L for Hg) via oral gavage for 28 days. After 28 days, compared with the control, red blood cell levels were increased for Cu + Hg. All other measured blood parameters were unchanged. Morphological changes in the tunica media were connective tissue deposition and an abundance of collagen type I in the metal exposed aortic tissues. In the cardiac tissue of metal-exposed rats, changes in the cardiomyocyte and myofibrillar arrangement, with an increase in collagen type I and III was observed. Ultrastructurally, the aortic collagen and elastin band arrangement and the cardiac mitochondrial and myofibrillar arrangement and structures were altered in the experimental groups. These changes indicated that exposure to these metals in rats caused minor changes in the blood parameters, however, the changes in tissue and cellular structure indicated an increased risk for the development of CVD.
Ethnic Differences in the Brazilian Population Influence the Impact of BMP4 Genetic Variants on Susceptibility of Nonsyndromic Orofacial Clefts
Authors: Rocha de Oliveira Lilianny Querino , de Souza Nicolau Hellen Carolliny , Barbosa Martelli Daniella Reis , Martelli-Júnior Hercílio , Scariot Rafaela , Ayroza Rangel Ana Lúcia Carrinho , de Almeida Reis Silvia Regina , Coletta Ricardo D. , Machado Renato Assis 
Published: June 2023

Objective The study evaluated the association of BMP4 tag-SNPs and SNP-SNP interactions involving genes active by BMP4 pathway during craniofacial development in the susceptibility of nonsyndromic orofacial clefts (NSOC) in the Brazilian population. Design Case-control study. Setting Brazilian Oral Cleft Group. Participants The study included 881 healthy controls and 800 patients with different types of NSOC: 232 with cleft lip only (NSCLO), 568 with cleft lip and palate (NSCLP), and 274 with cleft palate only (NSCPO). Interventions The genomic DNA was genotyped with allelic discrimination assays for five BMP4 tag-SNPs (rs11623717, rs17563, rs2071047, rs2761887 and rs4898820), and analyzed their allelic and genotypic associations using multiple logistic regression. The interactions of these variants with genes involved in the BMP4 signaling pathway, including FGFR1, GREM1, NOG, VAX1 and the 4p16.2 locus, were explored. Main outcome measures BMP4 variants in the NSOC risk. Results Although only nominal p values were identified when the whole sample was considered, subgroup analysis including the patients with high African genomic ancestry showed significant associations of rs2761887 with risk for nonsyndromic cleft lip with or without cleft palate (NSCL  ±  P)[(ORhom: 2.16; 95% CI: 1.21–3.85; p  =  0.01) and (ORrec: 2.05; 95% CI: 1.21–3.47; p  =  0.006)]. Thirteen significant SNP-SNP interactions involving BMP4 and the SNPs at FGFR1, GREM1, NOG and VAX1 and at locus 4p16.2 for increased risk of NSCL  ±  P were identified. Conclusions Our results demonstrate an increased risk of NSCL  ±  P in Brazilian individuals with enrichment of African ancestry in the presence of the BMP4 rs2762887 polymorphism, and reveal relevant genetic contribution of SNP-SNP epistatic interactions involving BMP4 variants to NSCL  ±  P risk.
Hepatorenal Syndrome With Acute Kidney Injury: Diagnosis and Medical Management
Authors: Erstad Brian L. 
Published: June 2023

Objectives: To review the current definitions and diagnostic criteria for acute kidney injury (AKI) and type 1 hepatorenal syndrome (HRS) now termed HRS-AKI and discuss the challenges in deciding the most appropriate medication regimens to treat patients with HRS-AKI. Data sources: PubMed (inception to April 2023) with bibliographies of retrieved articles searched for additional articles; organizational websites for clinical practice guidelines (CPGs). Study selection and data extraction: Randomized controlled trials (RCTs) evaluating albumin and vasoconstrictors for HRS-AKI. Data synthesis: A major change in the most recent revision of definitions and diagnostic criteria for HRS-AKI is the elimination of the set cutoff serum creatinine values for AKI. This change should be considered when comparing studies of HRS-AKI over time. Albumin has been administered to both vasoconstrictor treatment and placebo groups in all recent RCTs; however, there has never been a large RCT evaluating a no-albumin group. Most prospective trials comparing a midodrine/octreotide combination or norepinephrine to placebo or terlipressin have enrolled less than 100 patients limiting any conclusions regarding clinically important outcomes. Terlipressin with albumin has shown mixed results for complete HRS-AKI reversal with no reductions in crude mortality but adverse effect concerns involving ischemic and pulmonary events. Relevance to patient care and clinical practice: Type 1 hepatorenal syndrome with acute kidney injury is a potentially life-threatening syndrome with diagnostic and treatment challenges. Albumin plus a vasoconstrictor has become the routine HRS-AKI treatment even though there has not been a large RCT evaluating a no-albumin group. Terlipressin is the vasoconstrictor of choice for HRS-AKI in current CPGs, but it has adverse effect concerns and, until recently, was not available in the United States. Conclusions: In conjunction with changes in the definitions and diagnostic criteria for HRS-AKI, debate continues regarding the optimal therapy for HRS-AKI, particularly considering recent trials demonstrating ischemic and pulmonary adverse events with terlipressin used in combination with albumin.
Outcomes Following Repair of Achilles Midsubstance Tears: Percutaneous Knotless Repair vs Open Repair
Authors: Stake Ingrid K. , Matheny Lauren M. , Comfort Spencer M. , Dornan Grant J. , Haytmanek C. Thomas , Clanton Thomas O. 
Published: June 2023

Background: Optimum treatment for acute Achilles tendon rupture results in high mechanical strength, low risk of complications, and return to preinjury activity level. Percutaneous knotless repair is a minimally invasive technique with promising results in biomechanical studies, but few comparison clinical studies exist. Our study purpose was to compare functional outcomes and revision rates following acute Achilles tendon rupture treated between percutaneous knotless repair and open repair techniques. Methods: Patients 18 years or older with an acute Achilles tendon rupture, treated by a single surgeon with either open repair or percutaneous knotless repair, and more than 2 years after surgery were assessed for eligibility. Prospective clinical data were obtained from the data registry and standard electronic medical record. Additionally, the patients were contacted to obtain current follow-up questionnaires. Primary outcome measure was Foot and Ankle Ability Measure (FAAM) activities of daily living (ADL). Secondary outcome measures were FAAM sports, 12-Item Short Form Health Survey (SF-12), Tegner activity scale, patient satisfaction with outcome, complications, and revisions. Postoperative follow-up closest to 5 years was used in this study. Results: In total, 61 patients were included in the study. Twenty-four of 29 patients (83%) in the open repair group and 28 of 32 patients (88%) in the percutaneous knotless repair group completed the questionnaires with average follow-up of 5.8 years and 4.2 years, respectively. We found no significant differences in patient-reported outcomes or patient satisfaction between groups (FAAM ADL: 99 vs 99 points, P = .99). Operative time was slightly longer in the percutaneous knotless repair group (46 vs 52 minutes, P = .02). Two patients in the open group required revision surgery compared to no patients in the percutaneous group. Conclusion: In our study, we did not find significant differences in patient-reported outcomes or patient satisfaction by treating Achilles tendon midsubstance ruptures with percutaneous knotless vs open repair. Level of Evidence: Level IlI, retrospective cohort study.
Drug-related problems among esophageal, gastric and colorectal cancer patients at the National and referral hospital in Kenya
Authors: Degu Amsalu , Karimi Peter N , Opanga Sylvia A , Nyamu David G 
Published: June 2023

Introduction Cancer therapy has remarkable potential for drug-related problems due to the high cytotoxicity and narrow therapeutic index of most anti-neoplastic regimens. However, there is a lack of comprehensive studies on drug-related problems in patients with gastrointestinal cancer in Kenya. Therefore, the present study aimed to investigate the prevalence, types and predictors of drug-related problems among gastrointestinal cancer patients at Kenyatta National Hospital. Methods A cross-sectional study was used to assess the prevalence of drug-related problems among a random sample of 160 esophageal, 103 gastric, and 96 colorectal cancer patients. Data were collected using a researcher-administered questionnaire and data abstraction tool after training the data collectors. Patient-specific details such as socio-demographic features, histological cancer types, cancer stage, comorbidity types, and treatment regimen were recorded after the review of medical records and patient interviews. The potential of drug-related problems was determined as per the standard guidelines. The data were entered and analysed using version 26.0 SPSS statistical software. Results Most esophageal (51.9%), gastric (59.2%), and colorectal (62.5%) cancer patients had a high prevalence of drug-related problems. The need for additional drug therapy and adverse drug reactions were the predominant categories of drug-related problems. Most adverse drug reactions identified had possible categories of causality score, mild severity levels, and definitely preventable types of adverse drug reactions among all gastrointestinal cancer patients. Comorbidity and advanced-stage disease were significant predictors of drug-related problems. Conclusions Drug-related problems were prevalent among gastrointestinal cancer patients in our setting. Comorbidity and advanced stages of disease were significant predictors of drug-related problems.
Viability of selected microorganisms in parenteral preparations for novel systemic anti-cancer therapy
Authors: Almasi Jannik , Knoll Laura , Thiesen Judith , Krämer Irene 
Published: June 2023

Background Risk factors for aseptic preparation of parenteral medicines encompass the growth-promoting nature of the preparation. Although many aqueous parenteral preparations do not have growth-promoting properties, inadvertently introduced microorganisms may remain viable. Knowledge about the viability of microorganisms in parenteral preparations can add useful information for assigning shelf life to preparations used to treat cancer patients. Aim The aim of the study was to assess the viability of four different facultative pathogenic microorganisms in 20 ready-to-administer parenteral preparations aseptically prepared in hospital pharmacies. Methods Samples of 20 different biologics and small molecules for systemic anti-cancer therapy were inoculated either with different bacteria (i.e., Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecium) or with Candida albicans suspension. The resulting test concentrations were 104–105 microorganisms per mL. Aliquots of inoculated test solutions were transferred in duplicate to tryptic soy agar plates at the time points 0, 4, 24, 48, 144 h. The plates were incubated for 24 h (bacterial strains) and 72 h ( C. albicans) at 37 °C and colony forming units (CFUs) were counted. Results In most test solutions, especially in monoclonal antibody solutions, increased CFU counts of P. aeruginosa and unchanged or increased CFU counts of E. faecium and S. aureus were registered . Pronounced nutritive properties of monoclonal antibodies and filgrastim were not registered. Azacitidine, pixantrone and vinflunine containing test solutions revealed species-specific bacteriostatic and even bactericidal activity. All test solutions, except nivolumab and pixantrone containing solutions, showed constant or increasing CFU counts of C. albicans after incubation. Conclusion Viability of the selected pathogenic microorganisms was retained in most of the tested biological and small molecule preparations used to treat cancer patients. Therefore, in pharmacy departments strict aseptic conditions should be regarded and the lack of antimicrobial activity should be considered when assigning shelf life to RTA parenteral preparations.