bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fearless dominance and leader effectiveness: A chance for excellency in leadership
Authors: Genau‐Hagebölling Hanna A. , Meurs James A. , Kückelhaus Bastian P. , Blickle Gerhard 
Published: September 2023

AbstractWe tested whether the fearless dominance trait, which originated in the psychopathy literature and is typically presumed to relate to non‐adaptive behaviors, also can lead to successful leader behaviors. According to Lykken's argument on fearlessness in psychopathy, the direction of the career path of individuals high on fearless dominance is mainly influenced by their level of pre‐vocational socialization, and prior research has found encouraging results for this view. Our goal was to test this hypothesis specifically in the leadership context. By connecting Lykken's fearlessness argument to a recent process model of leadership by Zaccaro and colleagues, we suggest that fearless dominance and successful pre‐vocational socialization (i.e., greater education) influence leadership outcomes via political skill. Our sample comprises 239 leaders, their superiors (N = 239), and a total of 457 subordinates. Using moderated mediation analyses, we show that leaders high on both fearless dominance and educational level possessed greater political skill at work, mediating improved job performance, transformational leader behavior, and team performance. However, for low educational level, this mediated relation is negative. We review our findings regarding Lykken's argument of successful fearlessness and provide an outlook for future research.
Nexus between government surveillance on executive compensation and green innovation: Evidence from the type of state‐owned enterprises
Authors: Li Qian , Maqsood Umer Sahil , Zahid R. M. Ammar 
Published: September 2023

AbstractThe Chinese government capped executive compensation in state‐owned enterprises (SOEs) to address income inequality and promote a more equitable distribution of wealth. This study investigates whether regulating top executives' pay alters their motivation for corporate green innovation (GI) initiatives. Using data from 2006 to 2018 for Chinese‐listed SOEs, the regression analysis and difference‐in‐difference methods revealed that government restrictions on executive compensation negatively affect GI. Furthermore, the types of SOE results show that the negative effect of pay restrictions on GI exists only in local SOEs, as opposed to central SOEs. Moreover, high managerial shareholding positively moderates this negative effect, demonstrating that the adverse effects of compensation restrictions are mitigated by the convergence of interests between managers and stakeholders. These findings are robust to instrumental variables and other robustness tests. This study provides policy recommendations for the government to boost its assistance in GI and establish new environment‐related incentives that motivate managers to promote GI and inspire enterprises to deploy sustainable environmental initiatives.
Can smartphone‐based response inhibition training elicit sustained changes in appetite, preference, and cravings for energy‐dense foods? A free‐living randomized controlled trial
Authors: Moore Halim , White Melanie J. , Finlayson Graham , King Neil 
Published: September 2023

AbstractBackgroundFood‐specific response inhibition training has been implemented as a strategy to modify food choices and reward‐related eating behaviours, but short‐term studies have produced equivocal findings.ObjectiveTo longitudinally assess the effect of a smartphone‐based response inhibition intervention on food reward, hedonic eating drive, and cravings in a free‐living setting.Methods84 adults (Mage = 30.49, SDage = 13.01, 52 female) with high responsivity to food cues or overweight/obesity were randomly assigned to a response inhibition training intervention (n = 45) or a control game (n = 39) at home during a training week, followed by a week with no training. Primary analyses compared groups on measures of explicit liking and implicit wanting for food of different energy densities, food cravings, and reward‐related eating throughout this two‐week period.ResultsA reduction was observed in explicit liking and implicit wanting for energy‐dense foods from baseline to post‐training independent of condition (ps < .001). These changes from baseline were sustained after a 1‐week latency period, also independent of condition (ps < .001). These effects coincided with similar observations of hedonic eating drive, tonic cravings, and control over cravings during the observation period (ps < .01).ConclusionsAlthough significant reductions in reward‐related appetite were observed, free‐living response inhibition training did not offer additional benefit over a control activity. Future intervention studies with observable food intake are needed to investigate which appetitive mechanisms most reliably predict eating behaviour over time.Trial RegistrationRetrospectively registered with ANZCTR [ACTRN12622001502729].
LINC01305 recruits basonuclin 1 to act on G‐protein pathway suppressor 1 to promote esophageal squamous cell carcinoma
Authors: Xiong Li , Tan Jinsong , Zhang Ruolan , Long Qiongxian , Xiong Rong , Liu Yanqun , Liu Yun , Tang Jiancai , Li Yan , Feng Gang , Song Guiqin , Liu Kang 
Published: September 2023

AbstractEsophageaL squamous cell carcinoma (ESCC) is one of the most common and lethal tumors, however, its underlying molecular mechanisms are not completely understood and new therapeutic targets are needed. Here, we found that the transcription factor basonuclin 1 (BNC1) was significantly upregulated and closely related to the differentiation and metastasis of ESCC. Furthermore, BNC1, LINC01305, and G‐protein pathway suppressor 1 (GPS1) had significant oncogenic roles in ESCC. In addition, in vivo experiments showed that knockdown of BNC1 indeed significantly inhibited the proliferation and metastasis of ESCC. We also revealed the molecular mechanism by which LINC01305 recruits BNC1 to the promoter of GPS1, and then GPS1 could mediate the JNK signaling pathway to promote the proliferation and metastases of ESCC. Taken together, we discovered the novel molecular mechanism by which LINC01305/BNC1 upregulates GPS1 expression to promote the development of ESCC, providing a new therapeutic target for ESCC.
Nutraceutical combination ameliorates imiquimod‐induced psoriasis in mice
Authors: Vijayapoopathi Singaravel , Ramamoorthy Rajalakshmi , Meganathan Jayaprakash , Kalaiyazhagan Ananthi , Bhuvarahamurthy Sridharan , Venugopal Bhuvarahamurthy 
Published: September 2023

AbstractPsoriasis is a chronic inflammatory skin disease that affects both localized and systemic regions of the body. This condition is characterized by the hyperproliferation of keratinocytes, resulting in skin thickening, scaling, and erythema. The severity of psoriasis depends on the extent of skin involvement, the location of the infection, and the symptoms that the person exhibits. While no cure exists, conventional therapies such as topical and systemic drugs are generally used to manage the exacerbation of symptoms. However, chronic use and overdose can lead to other severe adverse effects. Therefore, scientists and researchers are exploring potential nutraceuticals that can be considered as an alternative source of management for psoriasis. Current research aims to use different combinations of natural compounds like cannabidiol, myo‐inositol, eicosapentaenoic acid, and krill oil to study the effect of these compounds in the prevention and treatment of psoriasis in the imiquimod (IMQ)‐induced psoriatic mice model. The Psoriasis Area Severity Index (PASI) scoring system is used to analyze skin thickness, scales, and erythema. The results indicate that the krill oil combined with the cannabidiol and myo‐inositol shows better results than other nutraceutical combinations. In the future, the natural products of krill oil can be combined with cannabidiol and myo‐inositol to create an improved alternative to existing steroidal and nonsteroidal anti‐inflammatory drugs for psoriasis treatment.
What is the impact of hospital and surgeon volumes on outcomes in rectal cancer surgery?
Authors: Boyle Jemma M. , van der Meulen Jan , Kuryba Angela , Cowling Thomas E. , Braun Michael S. , Aggarwal Ajay , Walker Kate , Fearnhead Nicola S. 
Published: September 2023

AbstractAimEvidence for a positive volume–outcome relationship for rectal cancer surgery is unclear. This study aims to evaluate the volume–outcome relationship for rectal cancer surgery at hospital and surgeon level in the English National Health Service (NHS).MethodAll patients undergoing a rectal cancer resection in the English NHS between 2015 and 2019 were included. Multilevel multivariable logistic regression was used to model relationships between outcomes and mean annual hospital and surgeon volumes (using a linear plus a quadratic term for volume) with adjustment for patient characteristics.ResultsA total of 13 858 patients treated in 166 hospitals were included. Six hospitals (3.6%) performed fewer than 10 rectal cancer resections per year, and 381 surgeons (45.0%) performed fewer than five such resections per year. Patients treated by high‐volume surgeons had a reduced length of stay (p = 0.016). No statistically significant volume–outcome relationships were demonstrated for 90‐day mortality, 30‐day unplanned readmission, unplanned return to theatre, stoma at 18 months following anterior resection, positive circumferential resection margin and 2‐year all‐cause mortality at either hospital or surgeon level (p values > 0.05).ConclusionAlmost half of colorectal surgeons in England do not meet national guidelines for rectal cancer surgeons to perform a minimum of five major resections annually. However, our results suggest that centralizing rectal cancer surgery with the main focus of increasing operative volume may have limited impact on NHS surgical outcomes. Therefore, quality improvement initiatives should address a wider range of evidence‐based process measures, across the multidisciplinary care pathway, to enhance outcomes for patients with rectal cancer.
Indeterminate etiology of acute liver failure in North America: Less common, still grave prognosis
Authors: Patel Parita V. , Livingston Sherry , Rakela Jorge L. , Stravitz R. Todd , Reuben Adrian , Bass Nathan M. , Tujios Shannan R. , Larson Anne M. , Sussman Norman L. , Rule Jody A. , Durkalski‐Mauldin Valerie L. , Lee William M. , Ganger Daniel R. ,   the Acute Liver Failure Study Group (ALFSG)
Published: September 2023

AbstractBackgroundThe etiology of acute liver failure (ALF) remains one of the most important factors in determining prognosis and predicting outcomes. In a significant proportion of ALF cases, however, the etiology remains unknown and is categorized as indeterminate ALF (IND‐ALF). In this study, we summarize findings from patients with IND‐ALF from 32 transplant centers across the United States, and we compare laboratory, prognostic, and outcome data for patients with IND‐ALF.MethodsBetween 1998 and 2019, 3364 adult patients with ALF or acute liver injury (ALI) from 32 liver transplant centers were enrolled in the ALFSG registry. The primary clinical outcome of interest was 21‐day transplant‐free survival (TFS).ResultsOf the 3364 patients enrolled in the ALFSG registry, 3.4 % (n = 114) were adjudicated as true indeterminate. On multivariate analysis, patients with a lower bilirubin, lower INR, lack of use of mechanical ventilation and no clinical features of coma at baseline had a higher odds ratio of transplant free survival. The number of deaths were similar between patients with true‐IND ALF versus patients with indeterminable ALF (29.8% vs. 27.2%), with almost half of the patients requiring liver transplant (42.1% vs. 45.7%).ConclusionWe illustrate the poor prognoses that true‐IND‐ALF and indeterminable ALF carry and the need for emergency liver transplantation in most cases.
BK polyomavirus DNAemia in pancreas transplant recipients compared to pancreas–kidney recipients
Authors: Yetmar Zachary A. , Kudva Yogish C. , Seville Maria Teresa , Bosch Wendelyn , Dean Patrick G. , Huskey Janna L. , Budhiraja Pooja , Jarmi Tambi , Kukla Aleksandra , Beam Elena 
Published: September 2023

AbstractBackgroundBK polyomavirus (BKV) infection is a common complication of kidney transplantation. While BKV has been described in non‐kidney transplant recipients, data are limited regarding its epidemiology and outcomes in pancreas transplant recipients.MethodsWe conducted a retrospective cohort study of adults who underwent pancreas transplantation from 2010–2020. The primary outcome was BKV DNAemia. Secondary outcomes were estimated glomerular filtration rate (eGFR) reduction by 30%, eGFR < 30 mL/min/1.73 m2, endstage kidney disease, and pancreas allograft failure. Cox regression with time‐dependent variables was utilized.ResultsFour hundred and sixty‐six patients were analyzed, including 74, 46, and 346 with pancreas transplant alone (PTA), pancreas‐after‐kidney, or simultaneous pancreas–kidney transplants, respectively. PTA recipients experienced a lower incidence of BKV DNAemia (8.8% vs. 32.9%; p < .001) and shorter duration of DNAemia (median 28.0 vs. 84.5 days). No PTA recipients with BKV DNAemia underwent kidney biopsy or developed endstage kidney disease. Lymphopenia, non‐PTA transplantation, and older age were associated with BKV DNAemia, which itself was associated with pancreas allograft failure (adjusted hazard ratio 2.14, 95% confidence interval 1.27–3.60; p = .004). Among PTA recipients, BKV DNAemia was not associated with eGFR reduction or eGFR < 30 mL/min/1.73 m2.ConclusionsBKV DNAemia was common among PTA recipients, though lower than a comparable group of pancreas–kidney recipients. However, BKV DNAemia was not associated with adverse native kidney outcomes and no PTA recipients developed endstage kidney disease. Conversely, BKV DNAemia was associated with pancreas allograft failure. Further studies are needed to estimate the rate of BKV nephropathy in this population, and further evaluate long‐term kidney outcomes.
Identifying obesity subtypes: A review of studies utilising clinical biomarkers and genetic data
Authors: Abraham Angela , Yaghootkar Hanieh 
Published: September 2023

AbstractObesity is a complex and multifactorial condition that poses significant health risks. Recent advancements in our understanding of obesity have highlighted the heterogeneity within this disorder. Identifying distinct subtypes of obesity is crucial for personalised treatment and intervention strategies. This review paper aims to examine studies that have utilised clinical biomarkers and genetic data to identify clusters or subtypes of obesity. The findings of these studies may provide valuable insights into the underlying mechanisms and potential targeted approaches for managing obesity‐related health issues such as type 2 diabetes.
Ecumenism of the Heart as a Path to Unity
Authors: Bedford‐Strohm Heinrich 
Published: September 2023

AbstractAs the World Council of Churches (WCC) celebrates its 75th anniversary, the world faces many challenges, including ecological crises, violence, pandemics, systemic poverty, racism, gender‐based violence, human rights violations, and the war in Ukraine that began in 2022. Taking as its basis the Unity Statement agreed at the WCC's 11th Assembly in Karlsruhe, Germany, in 2022, which met around the theme “Christ's love moves the world to reconciliation and unity,” the article argues for an “ecumenism of the heart,” of which the statement spoke, as a path to unity. It underlines that this is a “public theology” based not on political abstinence but on a passion for and renewed commitment to the world. The article concludes by exploring the challenges of such a public theology for justice, peace, and the integrity of creation.
Gendered executive headhunting with Chinese characteristics
Authors: Yan Li , Plimmer Geoff , Zhou Ao 
Published: September 2023

AbstractWomen executives face many barriers to career advancement, which then limits the advancement of women lower down the hierarchy. This study looks at the secretive and elite world of executive search (headhunting) as a gatekeeping system that hinders women's career advancement in China. Interviews were carried out with headhunters in China, including two in Taiwan to test transferability. Findings of this study show that executive women in China face more stark barriers than their western peers. Headhunters report little influence over clients, but they help profile jobs that emphasize technical and masculine views of leadership, ‘fit’ and ‘chemistry’ in hiring decisions, reinforce stereotypes, and do not support candidates. Our findings reflect the convergence of Confucianism, a highly competitive economic model, and a closed political system with limited space to promote women's interests. Headhunting, an imported practice, illuminates western individualist models of feminism rather than China's traditional collectivism and local models of feminism.
Ki67 proliferation index in medullary thyroid carcinoma: a comparative study of multiple counting methods and validation of image analysis and deep learning platforms
Authors: Nadeem Saad , Hanna Matthew G , Viswanathan Kartik , Marino Joseph , Ahadi Mahsa , Alzumaili Bayan , Bani Mohamed‐Amine , Chiarucci Federico , Chou Angela , De Leo Antonio , Fuchs Talia L , Lubin Daniel J , Luxford Catherine , Magliocca Kelly , Martinez Germán , Shi Qiuying , Sidhu Stan , Al Ghuzlan Abir , Gill Anthony J , Tallini Giovanni , Ghossein Ronald , Xu Bin 
Published: September 2023

AimsThe International Medullary Thyroid Carcinoma Grading System, introduced in 2022, mandates evaluation of the Ki67 proliferation index to assign a histological grade for medullary thyroid carcinoma. However, manual counting remains a tedious and time‐consuming task.Methods and resultsWe aimed to evaluate the performance of three other counting techniques for the Ki67 index, eyeballing by a trained experienced investigator, a machine learning‐based deep learning algorithm (DeepLIIF) and an image analysis software with internal thresholding compared to the gold standard manual counting in a large cohort of 260 primarily resected medullary thyroid carcinoma. The Ki67 proliferation index generated by all three methods correlate near‐perfectly with the manual Ki67 index, with kappa values ranging from 0.884 to 0.979 and interclass correlation coefficients ranging from 0.969 to 0.983. Discrepant Ki67 results were only observed in cases with borderline manual Ki67 readings, ranging from 3 to 7%. Medullary thyroid carcinomas with a high Ki67 index (≥ 5%) determined using any of the four methods were associated with significantly decreased disease‐specific survival and distant metastasis‐free survival.ConclusionsWe herein validate a machine learning‐based deep‐learning platform and an image analysis software with internal thresholding to generate accurate automatic Ki67 proliferation indices in medullary thyroid carcinoma. Manual Ki67 count remains useful when facing a tumour with a borderline Ki67 proliferation index of 3–7%. In daily practice, validation of alternative evaluation methods for the Ki67 index in MTC is required prior to implementation.
Innovative sound absorption technique: Step‐shaped ceramic fiberboards with veneer attachment for walls
Authors: Kang Chun‐Won , Choi Byung‐Sook , Zhu Shaohua , Hashitsume Kazuharu , Kolya Haradhan 
Published: September 2023

AbstractThe subject of the present paper is improving sound absorption properties and protecting the dust generation of ceramic fiber boards. The two‐microphone impedance tube method measured the sound absorption coefficient (SAC) of ceramic fiberboards (CFB) with different shapes and sizes. The wood veneer was used to cover the ceramic fiberboard (VCFB) surface to improve the wall's appearance and prevent dust generation. The step‐shaped ceramic fiberboards with veneer attached (VCFBS) revealed improved SAC (.98, 2000 Hz) compared with CFB and VCFB. The noise reduction coefficient (NRC) and sound absorption average showed a 100% improvement compared to CFB. The surface morphology and air permeability were analyzed using a scanning electron microscope and a capillary flow porometer to correlate with the findings. Furthermore, the porosity and pore diameter of the CFB were also studied to gain a comprehensive understanding of its acoustic properties and sound absorption capabilities. Statistical T‐tests revealed significant variations in the SAC (p ≤ .005). Besides, the obtained SAC was compared with other reported sound‐absorbing materials. These findings suggest that using step‐shaped ceramic fiberboard covered with a wood veneer can significantly absorb sound and improve the living environment. This novel approach offers potential advancements in sound‐absorbing materials for building construction.
High variability in Factor IX one‐stage assay in samples spiked with nonacog beta pegol among different pairs of reagent/detection system
Authors: Duboscq C. , Sueldo E. , Rosa C. , Zirpoli M. , Ceresetto J. , Baques A. , Arias M. 
Published: September 2023

AbstractIntroductionHaemophilia B (HB) is an X‐linked hereditary bleeding disorder characterized by coagulation factor IX (FIX) deficiency. To improve the quality of life of patients and adherence to treatment, recombinant factor concentrates modified to extend their half‐life have been developed, called extended half‐life factors (EHL: extended half‐life). Nonacog beta pegol (N9‐GP) is a glycopegylated recombinant human FIX molecule that has a half‐life of 93 h with a single dose and has shown a higher recovery percentage than other molecules. To diagnose and monitor the treatment of haemophiliac patients, FIX activity is determined with the one‐stage clotting assay (OSA) and/or the chromogenic assay. The objective of this work, carried out in three centres, was to measure the recovery of N9‐PG with 10 different activated partial thromboplastin time (APTT) reagents on three platforms, in samples spiked in vitro with N9‐GP, at four different concentration levels.MethodsIt was measured the recovery of N9‐GP with 10 different APTT reagents (polyphenol, ellagic acid, silice dioxide, colloidal silica as APTT activator on three platforms, in sample spiked in vitro with N9‐GP.ResultsThe results show heterogeneity in the activity of N9‐GP measured by OSA with the different APTT reagents when the calibrations were performed with the specific calibrator of each coagulometer. A recovery percentage between 87% and 108% was obtained only with polyphenol and ellagic acid as activator in the three platforms evaluated. The other reagents studied overestimate or underestimate, with no clear profile. When a calibration curve was performed with a calibrator prepared from the N9‐GP vial, all APTT reagents met the established recovery requirement.ConclusionAPTT reagents with polyphenol or ellagic acid as activator would be the only ones appropriate when using the commercially available OSA with specific calibrator to monitor patients treated with N9‐GP.