bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of service facilities and amenities with adolescent birth rates in Mexican cities
Authors: Braverman-Bronstein Ariela , Vidaña-Pérez Dèsirée , Diez Roux Ana V. , Pérez Ferrer Carolina , Sánchez Brisa N. , Barrientos-Gutiérrez Tonatiuh 
Published: July 2023

Abstract
Background
The association of the built environment and the structural availability of services/amenities with adolescent birth rates (ABR) has been overlooked in Latin America. We investigated the association of the availability, and changes in the availability, of services/amenities with ABR in 92 Mexican cities.

Methods
We estimated ABR using data on live birth registration linked to municipality of residence at the time of birth from 2008–2017. The number of services/amenities were obtained from the National Statistical Directory of Economic Units in 2010, 2015, and 2020 and grouped as follows: education, health care, pharmacies, recreation, and on- and off-premises alcohol outlets. Data were linearly interpolated to obtain yearly estimates. We estimated densities per square km by municipality. We fitted negative binomial hybrid models, including a random intercept for municipality and city, and adjusted for other social environment variables.

Results
After adjustment a 1-unit increase in the density of recreation facilities, pharmacies, and off-premises alcohol outlets within municipalities was associated with a 5%, 4% and 12% decrease in ABR, respectively. Municipalities with higher density of education, recreational and health care facilities had a lower ABR; in contrast, municipalities with a higher density of on-premises alcohol experienced a higher ABR.

Conclusion
Our findings highlight the importance of economic drivers and the need to invest in infrastructure, such as pharmacies, medical facilities, schools, and recreation areas and limit the availability of alcohol outlets to increase the impact of current adolescent pregnancy prevention programs.
Content of clinicians’ communication with patients suffering from spinal pain in assessment situations in a specialized spine center: A qualitative study evaluating psychologically informed pain assessments before and after clinicians’ participation in an Acceptance and Commitment Therapy course
Authors: Ravn Sophie Lykkegaard , Andersen Tonny Elmose , Schiøttz-Christensen Berit 
Published: July 2023

Abstract
Introduction
Assessment is an important part of chronic pain rehabilitation and should be conducted in line with the current biopsychosocial conceptualization of pain to capture the subjectivity and context of pain. However, pain assessment is commonly conducted from a biomedical framework. A course in Acceptance and Commitment Therapy (ACT) was provided to spinal pain clinicians as a framework to promote more person-centered and psychosocially focused assessments and related psychologically informed practices. The purpose of this qualitative study was to explore the verbal content of clinicians’ communication with patients experiencing spinal pain in assessment situations before and after clinicians participated in an ACT course.

Methods
Pain assessments of patients with chronic low back pain conducted by six spinal pain clinicians from different professions were audio-recorded and transcribed. This was done before and after participation in an eight-day ACT course with four following supervisions. A thematic analysis was carried out by two authors across all material, and a comparison of the applied number of codes pre-course and post-course was carried out as an indicator of change.

Results
Data consisted of transcripts from the six clinicians across 23 different patients (12 before course participation). Through analysis, 11 codes were developed, which were clustered in three overarching themes: Psychological domains, Communication Techniques, and Intervention Elements. Overall, there was an increase in the application of many of the codes in the transcripts from pre-course to post-course, however with large differences across codes. Increases were primary related to the discussion of life values and value-based action and quality of life as well as the employment of mirroring, challenging beliefs and assumptions, and addressing coping and pacing.

Conclusions
While not the case for all factors, the present findings indicate an increase in including psychological factors and employing interpersonal communication skills after a course in ACT. However, it remains unknown due to the design if the changes reported in this study reflect a clinically valuable change and whether they are due to the ACT training itself. Future research will improve our understanding of the effectiveness of this type of intervention in assessment practices.
Effects of a back school-based intervention on non-specific low back pain in adults: a randomized controlled trial
Authors: Hernandez-Lucas Pablo , Leirós-Rodríguez Raquel , Mota Jorge , García-Soidán José L. 
Published: July 2023

Abstract
Background
Non-specific low back pain is a common condition with significant global prevalence and socio-economic impact. Back School programs, which combine exercise and educational interventions, have been used to address back pain. This study aimed to investigate the effects of a Back School-based intervention on non-specific low back pain in adults. Secondary objectives included evaluating the impact of the program on disability, quality of life, and kinesiophobia.

Methods
A randomized controlled trial was conducted involving 40 participants with non-specific low back pain, who were divided into two groups. The experimental group underwent an 8-week Back School-based program. The program comprised 14 practical sessions focusing on strengthening and flexibility exercises, along with two theoretical sessions covering anatomy and concepts related to a healthy lifestyle. The control group maintained their usual lifestyle. Assessment instruments included the Visual Analogue Scale, Roland Morris disability questionnaire, Short-Form Health Survey-36, and Tampa Scale of Kinesiophobia.

Results
The experimental group showed significant improvements in the Visual Analogue Scale, Roland Morris disability questionnaire, physical components of the Short-Form Health Survey-36, and Tampa Scale of Kinesiophobia. However, there were no significant improvements in the psychosocial components of the Short-Form Health Survey-36. In contrast, the control group did not show significant results in any of the study variables.

Conclusions
The Back School-based program has positive effects on pain, low back disability, physical components of quality of life, and kinesiophobia in adults with non-specific low back pain. However, it does not appear to improve the participants' psychosocial components of quality of life. Healthcare professionals can consider implementing this program to help reduce the significant socio-economic impact of non-specific low back pain worldwide.

Trial registration
NCT05391165 (registered prospectively in ClinicalTrials.gov: 25/05/2022).
Chronic allergic asthma induces T-cell exhaustion and impairs virus clearance in mice
Authors: Ahn So Yeon , Lee Jueun , Lee Dong-Ha , Ho Thi Len , Le Chau Thuy Tien , Ko Eun-Ju 
Published: July 2023

Abstract
Background
Allergic asthma, one of the most common types of asthma, is thought to be highly susceptible to respiratory viral infections; however, its pathological mechanism needs to be elucidated. Recent studies have found impaired T-cell function in asthmatic mice. Therefore, we aimed to investigate the way by which asthma induction affects T-cell exhaustion in the lungs and assess the relationship between T-cell exhaustion and influenza viral infection.

Methods
Chronic allergic asthma mice were induced by intranasal injection of ovalbumin for 6 weeks and asthmatic features and T cell populations in lung or airway were assessed. To determine the influenza virus susceptibility, control and asthma mice were challenged with the human influenza virus strain A/Puerto Rico/8/1934 H1N1 and evaluated the survival rate, lung damage, and virus titer.

Results
Six weeks of OVA sensitization and challenge successfully induced chronic allergic asthma in a mouse model showing significant increase of sera IgE level and broncho-pathological features. A significant decrease in interferon-γ-producing T-cell populations and an increase in exhausted T-cell populations in the lungs of OVA-induced asthmatic mice were observed. Asthmatic mice were more susceptible to influenza virus infection than control mice showing lower survival rate and higher virus titer in lung, and a positive correlation existed between T-cell exhaustion in the lung and virus titer.

Conclusions
Asthma induction in mice results in the exhaustion of T-cell immunity, which may contribute to the defective capacity of viral protection. This study demonstrates a correlation between asthma conditions and viral susceptibility by investigating the functional characteristics of T-cells in asthma. Our results provide insights into the development of strategies to overcome the dangers of respiratory viral disease in patients with asthma.
5G millimeter wave wideband MIMO antenna arrays with high isolation
Authors: Megahed Amany A. , Abdelhay Ehab H. , Abdelazim Mohamed , Soliman Heba Y. M. 
Published: July 2023

AbstractIn this paper, a compact two-port MIMO antenna array system is described. The antenna array spans the range from 27 to 40 GHz, whereas the impedance of the antenna element is matched at 50 Ω. The gain of the antenna element is between 5.5 and 8.5 dBi, and its radiation efficiency is between 65 and 90%. With high impedance matching for 5G MMW (Millimeter Wave), particularly at 28 GHz and 38 GHz, the 2-port antenna array operates in the frequency range of 27–40 GHz. The suggested MIMO array operates effectively with a gain of approximately 10 dBi and a radiation efficiency of approximately 95%. The antenna array's overall dimensions are a length of 55.27 mm, a width of 27.635 mm, and a depth of 1.6 mm with partial ground. A FR-4 substrate is used in the antenna's fabrication, greatly reducing the cost. In the antenna array, a decoupling surface is used between the antennas, with orthogonality being maintained between the ports to reduce mutual coupling. The results of the modelling show a reduction in the measured mutual coupling between array ports of less than − 35 dB. An envelope correlation coefficient (ECC) of less than 1 × 10–4 is preferable. Additionally, the channel loss capacity is less than 0.3 bits/s/Hz, the mean effective gain is approximately − 6 dB, and the total active reflection coefficient is upgraded to be less than − 30 dB. Moreover, a diversity gain of approximately 10 dB is achieved. The proposed construction was created using CST Microwave Studio 2019. When the antennas are constructed and tested, the experimental outcomes surpass those of the simulation. Each antenna element is 27.635 mm long, 27.635 mm wide, and 1.6 mm thick. Slots in the radiating circular patch antenna element could be used to improve the radiation characteristics across the intended bands. The parametric study specifies that the distance between the antenna elements should be 0.5 λ, where λ is the operational wavelength.
Witnessing workplace bullying — protocol for a systematic review and meta-analysis of individual health and well-being outcomes
Authors: Nielsen Morten Birkeland , Rosander Michael , Einarsen Ståle Valvatne 
Published: July 2023

Abstract
Background
Most research on workplace bullying has examined the impact of the mistreatment on those exposed. Although bullying also is assumed to have significant ripple effects on bystanders, the empirical evidence for this line of research is highly fragmented and inconclusive. The overarching aim of this planned systematic review and meta-analysis is therefore to determine whether witnessing bullying of others at the workplace is associated with health problems and lower well-being among the observers. To achieve this aim, the review includes an assessment of which theoretical frameworks and methodological designs used in research so far and shed light on which confounders, mediators, and moderators that have been accounted for.

Methods
A systematic review and meta-analysis will be conducted. Electronic databases will be searched using pre-defined search terms to identify relevant studies. Eligible studies should report empirical findings on any individual outcome variable assessed among witnesses to workplace harassment and bullying or any overlapping concept. Primary observational studies with cross-sectional or prospective research design, case–control studies, and studies with experimental designs will be included. Qualitative interviews and case studies will be excluded. The methodological quality of the included studies will be assessed with a previously established checklist for studies on workplace bullying. The quality of evidence for an association between witnessing bullying and potential outcomes will be evaluated in accordance with the GRADE system. A random effects meta-analysis will be conducted with the Comprehensive Meta-Analysis software, version 3.

Discussion
We expect that findings on outcomes of bystanding to workplace bullying will provide practitioners with an understanding of the effects workplace bullying may have also on non-targets and the workplace as a whole. Such information is important regarding the development and implementation of effective measures and interventions against bullying. In addition, the review will increase our understanding of existing research gaps and enable us to make recommendations to address them. Our work aligns with the sustainable development agenda to protect workers and reduce inequalities at the workplace.

Systematic review registration
PROSPERO 342006.
Perioperative redox changes in patients undergoing hepato-pancreatico-biliary cancer surgery
Authors: Stevens Jia L. , McKenna Helen T. , Filipe Helder , Lau Laurie , Fernandez Bernadette O. , Murray Andrew J. , Feelisch Martin , Martin Daniel S. 
Published: July 2023

Abstract
Background
Tissue injury induces inflammation and the surgical stress response, which are thought to be central to the orchestration of recovery or deterioration after surgery. Enhanced formation of reactive oxygen and nitrogen species accompanies the inflammatory response and triggers separate but integrated reduction/oxidation (redox) pathways that lead to oxidative and/or nitrosative stress (ONS). Quantitative information on ONS in the perioperative period is scarce. This single-centre exploratory study investigated the effects of major surgery on ONS and systemic redox status and their potential associations with postoperative morbidity.

Methods
Blood was collected from 56 patients at baseline, end of surgery (EoS) and the first postoperative day (day-1). Postoperative morbidity was recorded using the Clavien-Dindo classification and further categorised into minor, moderate and severe. Plasma/serum measures included markers of lipid oxidation (thiobarbituric acid-reactive substances; TBARS, 4-hydroxynonenal; 4-HNE, 8-iso-prostaglandin F2⍺; 8-isoprostanes). Total reducing capacity was measured using total free thiols (TFTs) and ferric-reducing ability of plasma (FRAP). Nitric oxide (NO) formation/metabolism was measured using cyclic guanosine monophosphate (cGMP), nitrite, nitrate and total nitroso-species (RxNO). Interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-⍺) were measured to evaluate inflammation.

Results
Both oxidative stress (TBARS) and nitrosative stress (total nitroso-species) increased from baseline to EoS (+14%, P = 0.003 and +138%, P < 0.001, respectively), along with an increase in overall reducing capacity (+9%, P = 0.03) at EoS and protein-adjusted total free thiols (+12%, P = 0.001) at day-1 after surgery. Nitrite, nitrate and cGMP concentrations declined concomitantly from baseline to day-1. Baseline nitrate was 60% higher in the minor morbidity group compared to severe (P = 0.003). The increase in intraoperative TBARS was greater in severe compared to minor morbidity (P = 0.01). The decline in intraoperative nitrate was more marked in the minor morbidity group compared to severe (P < 0.001), whereas the cGMP decline was greatest in the severe morbidity group (P = 0.006).

Conclusion
In patients undergoing major HPB surgery, intraoperative oxidative and nitrosative stress increased, with a concomitant increase in reductive capacity. Baseline nitrate was inversely associated with postoperative morbidity, and the hallmarks of poor postoperative outcome include changes in both oxidative stress and NO metabolism.
Dynamic profiling of medulloblastoma surfaceome
Authors: Bakhshinyan David , Suk Yujin , Kuhlmann Laura , Adile Ashley A. , Ignatchenko Vladimir , Custers Stefan , Gwynne William D. , Macklin Andrew , Venugopal Chitra , Kislinger Thomas , Singh Sheila K. 
Published: July 2023

AbstractMedulloblastoma (MB) is the most common type of malignant pediatric brain cancer. The current standard of care (SOC) involves maximal safe resection and chemoradiotherapy in individuals older than 3 years, often leading to devastating neurocognitive and developmental deficits. Out of the four distinct molecular subgroups, Group 3 and 4 have the poorest patient outcomes due to the aggressive nature of the tumor and propensity to metastasize and recur post therapy. The toxicity of the SOC and lack of response in specific subtypes to the SOC underscores the urgent need for developing and translating novel treatment options including immunotherapies. To identify differentially enriched surface proteins that could be evaluated for potential future immunotherapeutic interventions, we leveraged N-glycocapture surfaceome profiling on Group 3 MB cells from primary tumor, through therapy, to recurrence using our established therapy-adapted patient derived xenograft model. Integrin 𝛼5 (ITGA5) was one of the most differentially enriched targets found at recurrence when compared to engraftment and untreated timepoints. In addition to being enriched at recurrence, shRNA-mediated knockdown and small molecule inhibition of ITGA5 have resulted in marked decrease in proliferation and self-renewal in vitro and demonstrated a survival advantage in vivo. Together, our data highlights the value of dynamic profiling of cells as they evolve through therapy and the identification of ITGA5 as a promising therapeutic target for recurrent Group 3 MB.
Safeguarding our dentistry heritage: a study of the history and conservation of nineteenth–twentieth century dentures
Authors: Neves Artur , Friedel Robert , Callapez Maria Elvira , Swank Scott D. 
Published: July 2023

Abstract
In the 1870s, dentures were one of the first products made with celluloid, the first semi-synthetic plastic. Despite the significance of denture development in the history of celluloid and plastics, the chemical characterization of dentures in museum collections has never been attempted. It is urgent to assess the extent of celluloid heritage in denture collections due to the high degradation risk that this material imposes. In this work, 21 dentures from the National Museum of American History and from the Dr. Samuel D. Harris National Museum of Dentistry were characterized using a multi-analytical methodology using handheld Raman, X-Ray fluorescence, and micro-Fourier transformed infrared spectroscopies. All dentures were successfully characterized: 12 are made of celluloid, 4 of vulcanized rubber, 2 of phenol–formaldehyde, 2 of polyvinyl chloride—polyvinyl acetate copolymer (PVC-PVAc) and 1 of polymethyl methacrylate (PMMA). The identification of the dentures’ base materials allowed a better understanding of their history and posed new questions about their conservation. Handheld Raman was demonstrated as an excellent in-situ tool for the study of polymeric materials.
Forces and moments generated by 3D direct printed clear aligners of varying labial and lingual thicknesses during lingual movement of maxillary central incisor: an in vitro study
Authors: Grant James , Foley Patrick , Bankhead Brent , Miranda Gabriel , Adel Samar M. , Kim Ki Beom 
Published: July 2023

Abstract
Objective
The objective of this study was to measure the forces and moments exerted by direct printed aligners (DPAs) with varying facial and lingual aligner surface thicknesses, in all three planes of space, during lingual movement of a maxillary central incisor.

Materials and methods
An in vitro experimental setup was used to quantify forces and moments experienced by a programmed tooth to be moved and by adjacent anchor teeth, during lingual movement of a maxillary central incisor. DPAs were directly 3D-printed with Tera Harz TC-85 (Graphy Inc., Seoul, South Korea) clear photocurable resin in 100-µm layers. Three multi-axis sensors were used to measure the moments and forces generated by 0.50 mm thick DPAs modified with labial and lingual surface thicknesses of 1.00 mm in selective locations. The sensors were connected to three maxillary incisors (the upper left central, the upper right central, and the upper left lateral incisors) during 0.50 mm of programmed lingual bodily movement of the upper left central incisor. Moment-to-force ratios were calculated for all three incisors. Aligners were benchtop tested in a temperature-controlled chamber at intra-oral temperature to simulate intra-oral conditions.

Results
The results showed that increased facial thickness of DPAs slightly reduced force levels on the upper left central incisor compared to DPAs of uniform thickness of 0.50 mm. Additionally, increasing the lingual thickness of adjacent teeth reduced force and moment side effects on the adjacent teeth. DPAs can produce moment-to-force ratios indicative of controlled tipping.

Conclusions
Targeted increases in thickness of direct 3D-printed aligners change the magnitude of forces and moments generated, albeit in complex patterns that are difficult to predict. The ability to vary labiolingual thicknesses of DPAs is promising to optimize the prescribed orthodontic movements while minimizing unwanted tooth movements, thereby increasing the predictability of tooth movements.