bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of economic efficiency of forestry tractor under production operation conditions
Authors: Пушков Ю.Л. , Кривоногова А.С. , Спиридонов С.В. 
Published: June 2023

Оценка экономичности в неустановившемся режиме, характерном для условий эксплуатации, затруднительна, поскольку нагрузочный и скоростной режимы постоянно меняются, изменяется и величина механических потерь в парах трения. В этом случае целесообразно оценивать экономичность с учетом затрат топлива и мощности на механические потери в парах трения, то есть по индикаторным показателям - удельному расходу топлива и индикаторноймощности. Величина часового расхода топлива и средней индикаторной мощности зависит от конструктивных параметров трактора, величины перевозимого груза, средней скорости движения и условий эксплуатации. Характер определяется передаточной функцией U ( s ) - динамической характеристикой частоты вращения двигателя. Гарантированные заводом-изготовителем двигателя, часовой и удельный расходы топлива, а также мощность отличаются от фактических значений при эксплуатации трактора вовсем диапазоне нагрузочных и скоростных режимов. Экспериментальные исследования различных типов двигателей с последующей аппроксимацией аналитическими выражениями амплитудно-частотных характеристик частоты вращения коленчатого вала позволили получить передаточную функцию частоты вращения, что в свою очередь дает возможность учитывать механические потери в парах трения двигателя в неустановившемся режиме при оценке экономической эффективности лесопромышленного трактора.
It is difficult to evaluate the efficiency in a non-stationary mode, which is typical for the operating conditions, as the loading and speed modes are constantly changing, and the value of mechanical losses in the friction pairs is also changing. In this case, it is advisable to evaluate the efficiency with regard to fuel and power consumption for mechanical losses in friction pairs, that is, according to indicator parameters - the specific fuel consumption and indicator power. The value of the hourly fuel consumption and the average indicator power depends on the design parameters of the tractor, the size of the transported cargo, the average speed and operating conditions. The character is determined by the transfer function U(s) - the dynamic characteristic of the engine speed. Guaranteed by the manufacturer of the engine, the hourly and specific fuel consumption and power differ from the actual values at operation of the tractor in the whole range of loading and speed modes. Experimental researches of different types of engines with the subsequent approximation by analytical expressions of amplitude-frequency characteristics of crankshaft rotation frequency have allowed to receive a transfer function of rotation frequency, which in turn gives an opportunity to consider mechanical losses in engine friction pairs in a non-stationary mode at estimation of economic efficiency of a forestry industrial tractor.
El contractualismo de Thomas Hobbes y el derecho penal del enemigo
Authors: Espinoza Ariza Jelmut 
Published: June 2023

El presente artículo explora de manera sucinta, en primer lugar, las principales ideas que giran en torno al contractualismo de Thomas Hobbes, quien es considerado como el primer filósofo político moderno, cuyo pensamiento político y social marca un corte epistemológico con la de sus predecesores al no estar fundada en el derecho divino, sino en un pacto entre seres humanos libres. La convencionalidad del lenguaje que asume Hobbes es un aporte del nominalismo; la confianza en la razón como método y como instrumento demostrativo basado en el modelo axiomático de la geometría, es propio del racionalismo de su época. En la segunda parte, entroncamos el pensamiento contractualista de Hobbes con el derecho penal del enemigo de Günther Jakobs, en el sentido de ofrecer una justificación razonable para considerar como enemigos a aquellos delincuentes que incurren en delitos que vulneran la seguridad del Estado.
Factores sociodemográficos, intra y extraescolares que afectan el proceso de deserción en estudiantes en situación vulnerables
Authors: Rodríguez Gallegos María del Refugio , Alvites-Huamaní Cleofé Genoveva 
Published: June 2023

El presente estudio tiene un enfoque metodológico cuantitativo, descriptivo, la muestra correspondió a 56 estudiantes de licenciatura en situación vulnerable del Centro Universitario de Ciencias Económico Administrativas (CUCEA) de la Universidad de Guadalajara (UdeG), el instrumento para la recolección de datos se conformó de dos secciones mediante las cuales se obtienen datos generales así como determinar qué factores intraescolares o extraescolares pueden incidir en la deserción escolar, de acuerdo a sus características sociodemográficas. El estudio dio como resultado que la deserción, no se determina por una decisión individual, sino que es el producto de la combinación de diversos factores de tipo extra escolares (económicos, necesidad de trabajar y estudiar, familiares, culturales, falta de interés o motivación) y factores intraescolares asociados a los procesos educativos, (infraestructura física, el equipamiento, la complejidad de las materias en la malla curricular, reformas al sistema educativo, empatía del personal) impactan en el proceso del abandono escolar.
Modeling runoff management strategies under climate change scenarios using hydrological simulation in the Zarrineh River Basin, Iran
Authors: Rahvareh Maliheh , Motamedvaziri Baharak , Moghaddamnia Alireza , Moridi Ali 
Published: June 2023

Abstract

Lake Urmia has experienced climate change over the last decades, dramatically reducing the water level. This study applies the Soil and Water Assessment Tool (SWAT) to evaluate runoff management strategies under different climate change scenarios in the Zarrineh River Basin. We examined two runoff management strategies: the projected runoff based on the business-as-usual (BAU) trend and the Changes in Cropping Pattern (CCP). The climate variables were downscaled and projected using Climate Change Toolkit (CCT) for the near future (2025–2049) and the far future (2075–2099) periods under two Representative Concentration Pathway (RCP) scenarios (2.6 and 8.5). The results revealed that runoff decreased by 6–23 and 9–52% for the near and far future, respectively, under the BAU scenario compared to the baseline period. Antithetically, it increased by 3.5–21 and 13–55% for the near and far future periods, respectively, based on the CCP strategy estimated up to 30% higher than the BAU strategy. The ﬁndings suggested that the CCP strategy can be considered a pragmatic management strategy since the surcharged runoff collected into Lake Urmia caused the mitigation of the imminent environmental disasters in the region and provided the environmental needs of its ecosystems.
Associação entre parto cesáreo e pressão arterial elevada em pré-escolares: um estudo transversal
Authors: Costa Jessica Santos Passos , Vieira Tatiana de Oliveira , Jesus Gilmar Mercês de , Vieira Graciete Oliveira , Oliveira Ana Mayra Andrade de , Adán Luís Fernando Fernandes 
Published: June 2023

O parto cesáreo é apontado como fator de risco para diversas doenças crônicas. Neste estudo, objetivou-se averiguar a associação entre parto cesáreo e pressão arterial (PA) de crianças de 6 anos. Trata-se de estudo transversal conduzido em Feira de Santana (BA), com 635 pares de mãe e filho. O tipo de parto foi categorizado em cesárea e vaginal. A PA foi aferida por meio de esfigmomanometria e considerada elevada quando atingiu níveis iguais ou maiores ao percentil 90 para idade, sexo e altura. Razões de prevalência brutas (RPbruta) e ajustadas (RPajustada) e respectivos intervalos de confiança de 95% (IC95%) foram estimados via regressão logística múltipla. A cesariana ocorreu em 46,5% dos casos, as prevalências de pressão arterial sistólica (PAS) e diastólica (PAD) elevadas foram de 17,2% e 5,6%, respectivamente. O excesso de peso foi verificado em 28,6% das crianças. A maior prevalência de PAS elevada foi observada entre as crianças que nasceram por cesariana (61%) em relação às que nasceram por parto vaginal (RPbruta: 1,51; IC95%: 1,07-2,14; RPajustada: 1,61; IC95%: 1,05-2,46). A idade materna ao nascimento da criança foi fator de interação na associação principal, assim, as crianças nascidas via parto vaginal exibiram maior prevalência de PAS elevada, comparadas às nascidas via cesárea. O parto cesáreo se associou à PAS elevada aos 6 anos de idade.
Perfil sociodemográfico de mulheres com câncer de colo do útero: avaliação da qualidade de vida
Authors: Araújo Thayane Costa Ferreira , Bezerra Kamilla Karem Silva , Almeida Joelson dos Santos , Sardinha Ana Hélia de Lima 
Published: June 2023

O câncer de colo do útero é um importante problema de saúde pública. Este trabalho objetiva avaliar a qualidade de vida de mulheres com câncer de colo do útero. Para tanto, foi realizado um estudo transversal com abordagem quantitativa, realizado com 175 mulheres em tratamento do câncer do colo do útero em um hospital de referência. Predominou a faixa etária de 40 a 59 anos (56%) com o diagnóstico, a maioria das pacientes eram pardas (69,8%), com ensino fundamental incompleto (44,7%) e casadas (42,3%). Com relação aos dados clínicos, a maioria referiu menarca aos > 12 anos (89,7%), coitarca aos < 18 (74,3%) e até cinco parceiros sexuais (88,6%). O tumor mais presente foi o carcinoma de células escamosas, com 90,3% dos casos; o estadiamento T3b/IIIB esteve em 41% dos registros; e 42,8% dos casos associaram radioterapia e quimioterapia para tratamento. A qualidade de vida pelo estado de saúde global foi satisfatória, com 72,1. Quanto aos domínios, na escala funcional a função social obteve média de 84,2, e, na escala de sintomas, a dificuldade financeira de 66,7. A qualidade de vida foi considerada satisfatória entre as pacientes, o que sinaliza melhoria das terapêuticas em saúde, planos de cuidado eficazes e trabalho em equipe multiprofissional que condiciona uma boa prática clínica.
Analysis of Patient Satisfaction on Healthcare Service with Potential Gain in Customer Value (PGCV) Method (Case Study: Children’s Poly Service at Puskesmas Simpang IV Sipin Kota Jambi)
Authors: Mardiani Isti , Rahmatika Daumi , Sutrisno Alya Triska , Aras Asfia Fitri 
Published: June 2023

Puskesmas Simpang IV Sipin Jambi still continuing to improve customer satisfaction. One indicator of the success of health services in Puskesmas is patient satisfaction. After observation, the reality of services at the puskesmas still does not meet customer expectations. This is because the Puskesmas has not prioritized what services need to be repaired and improved. This study uses the Potential Gain in Customer Value (PGCV) method to find out the description of the service desired by the customer. This research is a quantitative descriptive research. The data taken was carried out by distributing online questionnaires to 120 respondents. The results of the PGCV analysis show that the Responsiveness attribute (3,277) and the two Tangible attributes (2,447), (2,188) become 3 priority focuses in improving service quality.
Keywords : Service Quality, Patient satisfaction, Potential Gain in Customer Value (PGCV).
Efektifitas penerapan model pembelajaran index card match pada materi pecahan kelas IV Sekolah Dasar
Authors: Nuraeni Risma Asfi , Karlimah Karlimah 
Published: June 2023

Penelitian ini bertujuan untuk mengetahui efektifitas penerapan model pembelajaran Index Card Match, Lebih khusus untuk mengetahui peningkatan kemampuan peserta didik dalam menghitung pecahan menggunakan model pembelajaran Index Card Match. Penelitian ini dilakukan menggunakan pendekatan kuantitatif dengan metode eksperimen sehingga proses pengumpulan data menggunakan instrumen tes yang berupa pre-test dan post-test untuk kemudian dianalisis jawaban peserta didik terhadap pemahaman dan pengetahuannya berkenaan dengan materi pecahan di kelas IV sehingga diketahui hasil dari uji coba model pembelajaran Index Card Match.. Subjek dalam penelitian ini adalah peserta didik kelas IVÂ SDN 2 Suka Laksana. Data jawaban pre-test dan post-test yang diperoleh dianalis menggunakan winstep dengan pemodelan rasch untuk memperoleh infomasi mengenai tingkat efektifitas implementasi model pembelajaran Index Card Match pada materi pecahan. Informasi yang dianalisis meliputi secara menyeluruh dari setiap item pertanyaan berdasarkan jawaban peserta didik, serta analisis dari setiap peserta didik berdasarkan jawaban semua item pertanyaan dalam test. Hasil penelitian memberikan informasi bahwa tingkat jawaban benar peserta didik terhadap item berada pada logit lebih dari 1,00, selain itu selisih skor yang diperoleh kelompok eksperimen menunjukan angka 32,50 dibanding dengan kelompok kontrol yang hanya meningkat 11,60 itu berarti bahwa implementasi model pembelajaran Index Card Match telah efektif untuk meningkatkan pemahaman dan kemampuan peserta didik dalam menguasai materi pecahan dan menjawab soal berkaitan dengan pecahan di kelas IV Sekolah Dasar.
Pengaruh penggunaan media pembelajaran powerpoint interaktif terhadap motivasi belajar siswa Sekolah Dasar pada pembelajaran IPA
Authors: Andri Nyimas Amelia , Ruswan Acep , Nurmahanani Indah 
Published: June 2023

AbstrakPenelitian ini dilatarbelakangi oleh kurangnya motivasi belajar siswa terhadap mata pelajaran di Sekolah Dasar. Tujuan utama penelitian ini untuk mengetahui pengaruh penggunaan media pembelajaran PowerPoint Interaktif terhadap motivasi belajar siswa Sekolah Dasar Pada Pembelajaran IPA di kelas IV SDN Pucung III. Metode penelitian yang digunakan Pre-eksperimental design dengan tipe One Grup Pretest-Posttest. Subjek dalam penelitian ini yaitu siswa kelas IV SDN Pucung III yang berjumlah 40 siswa, terdiri dari 20 siswa laki-laki dan 20 siswa perempuan. Teknik pengumpulan data menggunakan angket motivasi belajar siswa yang sebelumnya sudah diuji kelayakannya melalui uji validitas dan reliabilitas. Teknik analisis data yang digunakan yaitu statistic deskriptif dan statistic inferensial. Berdasarkan hasil penelitian menunjukkan bahwa, peningkatan motivasi belajar yang ditunjukkan pada nilai rata-rata N-Gain yang diperoleh dari data pretest-posttest adalah sebesar 0,605 dan berada pada kategori sedang. Uji hipotesis menggunakan uji Paired Sample t-test diperoleh nilai sig. (2-tailed) untuk angket yaitu 0,000 < 0,05, maka H0 ditolak dan H1 diterima. Hasil penelitian menunjukkan adanya pengaruh penggunaan media pembelajaran PowerPoint Interaktif terhadap motivasi belajar setelah diberi perlakuan (treatment).Â Kata Kunci: Media Pembelajaran interaktif, Power Point Interaktif, Motivasi BelajarÂ ABSTRACTThis research is motivated by the lack of student motivation towards subjects in elementary schools. The main objective of this study was to determine the effect of using Interactive PowerPoint learning media on the learning motivation of elementary school students in learning science in class IV SDN Pucung III. The research method used was Pre-experimental design with the type One Group Pretest-Posttest. The subjects in this study were fourth grade students at SDN Pucung III, totaling 40 students, consisting of 20 male students and 20 female students. The data collection technique uses a questionnaire on student learning motivation which has previously been tested for its feasibility through validity and reliability tests. Data analysis techniques used are descriptive statistics and inferential statistics. Based on the results of the research, it shows that the increase in learning motivation is shown in the average N-Gain value obtained from the pretest-posttest data which is 0.605 and is in the medium category. Hypothesis testing using the Paired Sample t-test obtained a sig value. (2-tailed) for the questionnaire, namely 0.000 < 0.05, then H0 is rejected and H1 is accepted. The results of the study showed that there was an effect of using Interactive PowerPoint learning media on learning motivation after being given treatment.Â Keywords: Interactive Learning Media, Interactive Power Point, Learning Motivation
10-LB: Activation of Sigma-1 Receptor as a Novel Therapeutic Target in Diabetic Kidney Disease
Authors: BALOGH DORA B. , LENART LILLA , HOSSZU ADAM , SAEED ADAR , HODREA JUDIT , TOTH AKOS R. , SZABO ATTILA J. , FEKETE ANDREA 
Published: June 2023

Introduction and aims: Diabetic kidney disease (DKD) is a major health concern among diabetic patients. Current therapies cannot halt the progression of renal failure; thus, the development of additional novel therapies is of paramount importance. We previously showed that the Sigma-1 receptor (S1R) agonism is protective in acute kidney injury (AKI). Inflammation and tubular hypoxia are key processes in the pathogenesis of DKD. S1R agonist treatment inhibits these pathologic pathways in AKI, therefore we assume that a similar protective effect can be shown in DKD as well.
Methods: Diabetes mellitus (DM) was induced by streptozotocin (65 mg/bwkg, ip.) in adult, male Wistar rats and they were treated for seven weeks with fluvoxamine (D+FLU, 20 mg/bwkg/day, po.). Metabolic parameters, renal function, and histology were evaluated. Inflammation was tested in lipopolysaccharide-stimulated (LPS, 1 µg/mL) human proximal tubular epithelial cells (HK-2). To test hypoxia cells were placed in a hypoxic chamber (1% O2, 2h). Cells were treated with 10 µM FLU. Proinflammatory and hypoxia markers were measured.
Results: Renal function (BUN: DM: 26.6±2.42 vs. DM+FLU: 17.3±2.30 mmol/L; Serum creatinine: DM: 42.0±2.39 vs.DM+FLU: 34.5±2.74 µmol/L; Proteinuria: DM: 42.5±6.38 vs. DM+FLU: 21.5±4.99 mg/mL; p&lt;0.05), structural damage (PAS staining), and fibrotic tissue accumulation (Masson’s trichrome staining) were reduced by FLU. FLU decreased LPS-induced IL6, TLR4, and NFKB1 expressions in HK-2 cells. Hypoxia-induced HIF1A and HIF2A elevation were suspended by FLU treatment. Moreover, VEGFA and SLC2A1 expressions were also increased in hypoxia and FLU prevented their elevation.
Conclusions: Activation of S1R slows the progression of chronic renal impairment in DKD. Moreover, S1R agonist FLU prevents hypoxic and inflammatory damage in HK-2 cells, which may explain the molecular mechanisms behind its renoprotective effect. We propose S1R as a novel target for the prevention of DKD.

Disclosure
D. B. Balogh: None. L. Lenart: None. A. Hosszu: None. A. Saeed: None. J. Hodrea: None. A. R. Toth: None. A. J. Szabo: None. A. Fekete: None.

Funding
National Research, Development and Innovation Fund (UNKP-22-4-II-SE-2, TKP2021-EGA-24); Hungarian Academy of Sciences (LP2021-3/2021)
100-OR: A Novel Macrophage-Regulation Drug for Treating Diabetic Foot Ulcer—A Phase III MRCT Study and Taiwan Experience
Authors: CHEN SHYI-GEN , CHU SHUN-TIEN , PU CHI-MING , CHEN JUI-CHING , WU YI-HSIN 
Published: June 2023

Macrophage regulation plays an essential role in Diabetic foot ulcer (DFU) healing. By recognizing the therapeutic potential in M1/M2-macrophage-regulation for DFUs, we aim to investigate the efficacy and safety of ON101, a topical new drug with a M1/M2-macrophage-regulating mechanism in phase 3 MRCT across the US, China, and Taiwan (NCT01898923). There are 236 eligible subjects with Wagner Grade 1 or 2 DFU(s), randomized 1:1 to receive ON101 or comparator for up to 16 weeks, followed by a 12-week follow-up. The incidence of complete healing was 60.7% by ON101 and 35.1% by the comparator (P=0.0001). The time to complete ulcer healing was faster in the ON101 group (P=0.002). Since the high levels of HbA1C, ulcer persistence, ulcer location, and amputation history as the risk factors leading to poor DFU outcomes, ON101 also showed demonstrated robust efficacy and safety in hard-to-heal ulcers. ON101, approved by Taiwan FDA in 2021, was shown with excellent therapeutic efficacy and safety in the treatment of DFUs. In a real-world scenario, case collation from 133 patients, ulcer severity with Wagner grade 1 to 4, after applying ON101, the average ulcer complete healing rate is 71%, no adverse events were related to ON101, which validates the drug safety of ON101. ON101 further supports its excellent ability to promote wound healing in DFU patients with various severities (Wagner grade 1 to 4). All those patients who applied ON101 alone or with other therapies reached ulcer healing under infection control and with necessary debridement. Macrophage-regulating drug achieved superior therapeutic efficacy in a large Phase 3 MRCT and has demonstrated excellent therapeutic efficacy in the real-world scenario where Wagner grade 3 and 4 DFUs reached ulcer healing when ON101 was combined with other therapies. This enlightens the future treatment in Wagner grade 1 to 4 DFUs by macrophage immunomodulation new drug as a promising solution.

Disclosure
S.Chen: Employee; Oneness Biotech Co., Ltd. S.Chu: None. C.Pu: None. J.Chen: Employee; Oneness Biotech Company. Y.Wu: Employee; Oneness Biotech Co., Ltd.
1068-P: Correleations of HbA1c, Continuous Glucose Monitor (CGM) Use, Insurance Type, and Language in a Large Pediatric Diabetes Practice in Phoenix, Arizona
Authors: ANN HOLZMEISTER LEA , CHMELNIK SANDRA 
Published: June 2023

Background: Inequities among technology use in pediatric type 1 diabetes (T1D) patients remains prevalent. These disparities contribute to poor glycemic control.
Method: This study was a retrospective chart review of HbA1C and CGM use by type of insurance, ethnicity and language spoken at home in 2022.
Results: In a cohort of nearly 2000 T1D pediatric patients, differences were found in HbA1c levels between ethnicities (mean of 8.6% Hispanics and 8.1% non-Hispanics). However, when stratified by insurance type (Private vs Medicaid), the relationship of ethnicity to HbA1C levels was no longer present, suggesting insurance drives differences in HbA1C levels rather than ethnicity. The effects of insurance may in part be related to technology use. An average of 45% of patients with private insurance use CGMs, in comparison with 32% of those with Medicaid. The use of CGMs compared with non-use of CGMs had a positive effect on HbA1C (8.3% vs 9.0%).
Conclusions: CGM use is associated with lower HbA1C levels in our practice. Patients on Medicaid had higher HbA1C levels and less use of CGM. Hispanic and non-English speaking patients were more likely to be on Medicaid, and to have higher HbA1C levels and lower use of CGMs. These findings highlight the need to reduce health inequities among these populations. Our clinic will aim to develop interventions to improve technology use and access in Medicaid, Hispanic, and non-English speaking populations.

Disclosure
L.Holzmeister: None. S.Chmelnik: None.