bluuebunny/crossref_metadata_2025_split huggingface dataset:
The AHAWOMEN Project: Study Protocol of a Multi-Design Research for Exploring HAPA Predictors of Exercise in Postmenopausal Women
Authors: Godoy-Izquierdo Débora , Lara-Moreno Raquel , Ogallar-Blanco Adelaida , González Juan , de Teresa Carlos , Mendoza Nicolás 
Published: June 2023

Abstract
Background
The postmenopausal period can represent an opportunity for women to improve their health and well-being. The Active and Healthy Ageing in Women during early postmenopause (AHAWOMEN) study aims to identify the key determinants of an active lifestyle among middle-aged women, with a focus on the stages and social-cognitive variables outlined in the Health Action Process Approach (HAPA) model, a theoretical framework for understanding health behaviour change. We expected that HAPA factors and processes of intention creation (motivational phase) and action adoption (volitional phase) will be significant predictors of exercise initiation and maintenance, supporting both the HAPA tenets and the efficacy of HAPA-based interventions.
Methods/Design:
This study was approved by the authors’ Institutional Review Committee. Postmenopausal women aged between 45 and 65 years will voluntarily participate. The participants will be allocated to one of three groups: Intervention-Initiators (n = 100, random allocation), Control-Sedentary (n = 100, random allocation) or Control-Active (n = 100, non-random allocation). The intervention group will engage in a supervised exercise programme lasting at least 3 months, supplemented with an HAPA-based intervention for behaviour change. The sedentary control group will not receive any intervention to change their physical activity, while the active control group will consist of women who are already regularly adhering to an active lifestyle. Study variables will be measured at baseline and postintervention phases, as well as at 1, 3, 6 and 12-month follow-ups. The predictors of exercise behaviour in the different phases of the behavioural change process will be explored and compared within and between groups throughout the study. This analysis will help identify the factors that determine the adoption of a healthy active behaviour. Additionally, the effectiveness of the model and the intervention for changing active behaviour will be evaluated.
Discussion
This paper describes the rationale, development and methods used in the AHAWOMEN project. Supporting women who intend to become active can help them to translate their goals into sustainable action. Verifying that the HAPA predictions are applicable to postmenopausal women’s adoption of exercise would provide the basis for designing effective interventions for promoting healthy and active ageing that are also tailored to the experiences of middle-aged women.
Trial registration:
ISRCTN16251361. Registration date: 01/06/2023 (retrospectively registered).
Study on buckling performance of a new type of double-steering prestressed plate-column
Authors: Li Yanying , Li Bailong 
Published: June 2023

Abstract
This study proposes a new type of prestressed stayed column. The traditional prestressed stayed beam-column does not consider the end constraint, whereas the new double-steering prestressed plate column exploits the end constraint while accounting for the middle bending deformation. The sliding form is utilized in this study for the connection part to prevent the prestressed steel cable from breaking at the pole. The results indicated that adding the steering brace improves the core steel column's stable bearing capacity and stiffness. The bearing capacity of the double-steering prestressed plate column is 4.51 times that of the non-prestressed bearing column, 2.43 times that of the characteristic buckling load of the currently prevalent single-transverse prestressed beam-column, and 1.51 times that of the traditional three-transverse prestressed beam-column. The influence of prestress magnitude, effective length, buckling mode, and double-steering plate-column details are investigated. The research findings further enrich and enhance the theory and types of prestressed stayed columns and provide guidance for applying new double-steering prestressed plate-column in practical engineering.
Digital watermarks for videos based on a locality-sensitive hashing algorithm
Authors: Sun Yajuan , Srivast Gautam 
Published: June 2023

Abstract
Sensitive information in images is leaked during attacks, resulting in the malicious acquisition of personal privacy. To improve the robustness of attacking defence for video images, a digital watermarking algorithm based on locality-sensitive hashing (LSH) is designed. The video signal was decomposed using a one-dimensional wavelet transform. According to the Yeung Mintzer (Y-M) algorithm, a marker watermark W1 was embedded in the low-frequency subband to identify image tampering. The data string of hash function values and the exclusive OR (XOR) result of identification watermark W2 were embedded into the HH high-frequency subband, which was used to identify and counter the pseudo-authentication attacks such as collage and Vector Quantization(VQ). The singular value decomposition (SVD) algorithm was used to decompose the hash-mapped watermark and adaptively adjust the embedding strength of the watermark. The position-sensitive hash algorithm proposed has good invisibility for embedding digital watermarks into images, with an average accuracy of approximately 97% for feature matching of digital images. The PSNR value of the image embedded with the watermark is approximately 49 dB. At the 50th minute of the experiment, the regulatory factor value of the research method was 0.3. Under different attack modes, the correlation coefficient between the watermark extracted by this method and the original watermark image is greater than 0.85. Due to the low compression quality of JPGE, the correlation coefficient between the watermark and the initial watermark is greater than 0.6, and its error rate is less than 0.10bit.
What are the most common controversial clinical issues in fertility preservation? A content analysis of a collaborative professional online consultation group
Authors: Tsafrir Avi , BenHaroush Avi , Hyman Jordana , Karavani Gilad , Imbar Tal 
Published: June 2023

Abstract
Research Question
Clinicians involved in fertility preservation (FP) are often required to make prompt and consequential decisions despite the absence of evidence-based data. We established a collaborative professional online consultation group for fertility preservation issues. We sought to determine the main controversial clinical issues in FP as raised by participants of this group.
Design
Content analysis of a dedicated community of practice interacting via a messaging application (WhatsApp) and a survey of group participants.
Results
Between January 2019 and July 2022, group members posed 39 clinical questions which were discussed and debated by the group. Common themes included management of oncofertility cases (33%), potential gonadotoxicity of various therapies (23 %), fertility preservation in women and girls with premature ovarian insufficiency (POI) (18%), and technical aspects of ovarian tissue cryopreservation (10%). All but one query received prompt response (mean time for first response for 95% of queries 7.1±9.0 minutes) from a mean of 5.4±3.2 members.
An anonymous online survey of group members was conducted during August 2022 (n=31, response rate 94%). The majority of respondents stated they gained knowledge and assistance in clinical decision making from participation in the discussion group (90% and 58% of respondents, respectively).
Conclusions
Management of clinical oncofertility cases, potential gonadotoxic effect of therapeutics and fertility preservation in women and girls with POI were the most common controversial issues in our fertility preservation community of practice. Intra-professional collaborative communication via a messaging application can aid in clinical management of fertility preservation and augment clinician’s knowledge.
Virtual Reality in Nonprofit Marketing: Boosting Inspiration and Encouraging Donations
Authors: Rodrigues Mariana Berga , Loureiro Sandra Maria Correia , Lopes Flávia de Sousa 
Published: June 2023

Abstract

Nonprofits often face the challenge of inspiring people to care about issues that are at distance, both geographically and emotionally. This study seeks to investigate how Virtual Reality (VR) can increase inspiration and encourage potential donors to give to nonprofits. Additionally, the study aims to analyze the moderating role of immersion level. A three-group between-subjects experiment with 142 participants was conducted to examine how immersiveness can influence presence, inspiration, and donation intention. The three different devices used (HMD, mobile HMDs, and computer desktop) to watch the documentary correspond to the different immersion levels (high, moderate, and low, respectively). Results reveal that perceived media richness enhances users’ spatial presence. Further, presence (spatial and social) positively effects customer inspiration. Lastly, findings suggest that customer inspiration increases donation intention. This study contributes to researchers and practitioners by identifying the role of customer inspiration on donation intention and by highlighting the impact of immersiveness.
Computation of Seepage Losses and Economic Analysis of Canal Lining- A Case Study of Hajira Branch Canal
Authors: Mistry khyati , Khasiya Rajabhai , Patel Jayanti 
Published: June 2023

Abstract
Canals are the major conveyance system of any irrigation project, delivering irrigation water to fields. Irrigation schemes include an extensive distribution system which is an expensive proposition. So, it is necessary to ensure that large water losses do not occur due to seepage. Most of these canals are earthen so considerable water losses occur due to seepage. These losses can be overcome by lining the bed and sides of the canal cross-section with impervious material. Canal lining improves the efficiency of the canal by reducing the canal seepage. Improved efficiency leads to saving huge amounts of irrigation water, and thereafter, can cover more land area under irrigation. The main aim of this study is to find out which kind of lining is best suited to canal cross-section in accordance with the cost criteria. The study area is the Hajira branch canal which takes off from the Kakarapar right bank main canal. The present work is divided into 3 parts. In the first part, seepage losses from the canal are computed. In the second part, different types of lining are studied and the lining which is best suited to the canal is selected and its design is done. In the third part cost estimation is done of the canal lining.
Evaluating the Seismic Behavior of RC Structures: A Comparative Study of Framed Tube and Shear Wall Systems for Varying Numbers of Stories
Authors: Sutar Sourabh , Patil Rahul D. 
Published: June 2023

Abstract
Through a comparison of framed tube systems and shear wall systems for various story counts, this work evaluates the seismic behaviour of reinforced concrete (RC) structures. The goal is to use the ETABS software to evaluate how well these structural systems perform when subjected to seismic and wind loads. Analysis of storey displacements, a crucial performance metric for both lateral load resisting systems, is the study's main objective. To analyse structures, we use the Response Spectrum Method. The findings show that the framed tube structure outperforms the shear wall system in terms of seismic resistance, showing decreased displacements, greater drift ratios, increased base shear forces, and improved structural ductility. These results imply that framed tube structures can be used as workable substitutes for tall buildings situated in seismic regions. To avoid excessive deformation and failure, it is necessary to include enough stiffness and strength in the design phase. The study also highlights how crucial it is to look into how material properties, loading patterns, and interactions between the structure and the ground affect these systems' seismic stability. The findings of this study show the earthquake resistance and dependability of framed tube structures and have major implications for high-rise building design and construction in seismic regions.
DNA extraction method affects diversity indices of ecosystem microbiota
Authors: Galla Giulio , Praeg Nadine , Rzehak Theresa , Sprecher Else , Colla Filippo , Seeber Julia , Illmer Paul , Hauffe Heidi Christine 
Published: June 2023

Abstract
Background
Metataxonomic studies of ecosystem microbiotas require the simultaneous processing of samples with contrasting physical and biochemical traits to guarantee that diversity indices are comparable. However, DNA extraction can induce undesired bias in the microbial community composition and hamper the detection of meaningful biological patterns in metataxonomic datasets. Therefore, to compare microbiotas of samples with different requirements for DNA extraction, the methodological variation resulting from the adoption of different extraction method needs to be considered and quantified. There are currently no studies in which different DNA extraction kits were compared across the main components of terrestrial ecosystems, such as soil, rhizosphere, invertebrate animals, and mammalian feces.
Results
Five DNA extraction kits designed for the extraction of nucleic acids from soil, feces and animal tissue were used to investigate the composition and diversity of microbota of a subset of samples typically studied in terrestrial ecosystems such as soil (bulk soil and rhizosphere soil), invertebrate taxa (Nematoda, Coleoptera) and mammalian feces (B. taurus and Lepus spp.) Our data shows that each DNA extraction method leads to significant differences in the relative abundance of several prokaryotic taxa. Furthermore, we demonstrate that kit selection has the potential to bias both alpha and beta diversity estimates. Importantly, the impact of DNA extraction kit on sample diversity estimates varies according to the sample type, with mammal feces and soil samples showing the most and least consistent results across DNA extraction kits, respectively.
Conclusion
The selection of DNA extraction kits for large-scale microbial ecological studies involving the comparison of microbiotas of heterogeneous sample types should consider sample susceptibility to methodological variation. From the comparisons of five DNA extraction kits commonly used to study soil, feces and invertebrates, we showed that NucleoSpin® Soil (MACHEREY-NAGEL; MNS) and QIAamp® Fast DNA Stool Mini (QIAGEN; QST) were associated with the highest and lowest alpha and beta diversity estimates across the different sample types, respectively. These observations indicate that MNS efficiently captures both the composition and diversity of microbial communities found in the terrestrial samples considered in this study, and we recommend its use for any large-scale microbiota study of terrestrial ecosystems.
Mechanism of circDYM/CEBPB/ZC3H4 axis in LPS-induced Microglial Apoptosis
Authors: Zhou Zhongqiu , Ye Qingqing , Ren Hui , Yang Li , Zhang Yuan , Han Bing , Yao Honghong , Bai Ying 
Published: June 2023

AbstractCircular RNAs (circRNAs) are a subtype of non-coding RNAs and contribute to the various central nervous system (CNS) diseases. However, microglia apoptosis which is regulated by circRNAs in major depressive disorder (MDD) is incompletely clear. Herein, we have shown that the circular RNA DYM (circDYM) binds to the transcription factor CEBPB, thereby releasing repression of CEBPB target gene ZC3H4 transcription. The result of our study provides new insights in function of circDYM to microglia apoptosis in depression. Taken together, we identify that circRNA drives neuroinflammation and serves as a new potential target for therapy of depression.
Transcranial direct current stimulation improves time perception in children with ADHD
Authors: Nejati Vahid , Mirikaram Fateme , Nitsche Michael 
Published: June 2023

Abstract

Background and purpose: Individuals with ADHD struggle with time perception. The ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC) are two distinct cortical areas that are involved in the psychopathology of ADHD, including time perception. In the present study, we aimed to explore if modulation of the excitability of these areas with non-invasive brain stimulation alters time perception in ADHD.
Material and methods: Twenty-six children with ADHD performed time discrimination and time estimation/reproduction tasks in five sessions with one week interval and specific tDCS conditions. The tDCS conditions were anodal left dlPFC/cathodal right vmPFC, the reversed electrode positioning, isolated anodal left dlPFC, right vmPFC stimulation with extracranial return electrodes, and sham stimulation.
Results: An improved time discrimination was observed in all real stimulation conditions compared to sham stimulation, however the results did not differ between real stimulation conditions. For the time reproduction/estimation task, anodal vmPFC/cathodal dlPFC, isolated anodal dlPFC stimulation and isolated anodal vmPFC stimulation with extracranial return electrodes improved time reproduction, but not estimation, compared to sham stimulation.
Conclusion: These results imply that the left dlPFC and right vmPFC are involved in time estimation, whereas the right vmPFC might be more critical for time reproduction. This finding is discussed in light of task and stimulus properties.
Predicting mortality in pediatric sepsis: A real-world data analysis using a pediatric sepsis surveillance method
Authors: Miura Shinya , Michihata Nobuaki 
Published: June 2023

Abstract
Purpose
Sepsis surveillance methods using electronic medical records based on the latest definition of sepsis are increasingly used to describe the real-world epidemiology of adult sepsis. However, its application in pediatric populations has been limited, and pediatric sepsis outside pediatric intensive care units has not been well studied. We aimed to determine whether this surveillance method could identify children with sepsis at high-risk of mortality and to evaluate the criteria for organ dysfunction within the method.
Methods
From an inpatient database including ≥ 200 acute-care hospitals in Japan, we included children of ≤ 21 years of age who were admitted to hospitals between 2014 and 2021, underwent blood culture tests, and received antimicrobial treatment for ≥ 4 days. We stratified these children into children with sepsis or without sepsis by the presence of organ dysfunction. We evaluated the discrimination for in-hospital mortality by the sepsis diagnosis, the number of organ dysfunction and modified criteria for sepsis diagnosis.
Results
Among 6553 eligible children, the in-hospital mortality was 7.2% in 875 children with sepsis and 0.2% in 5678 children without sepsis. Sepsis diagnosis discriminated in-hospital mortality with a sensitivity of 0.84 and a specificity of 0.87. In-hospital mortality incrementally increased with the number of organ dysfunction; zero, 0.2%; one, 3.4%; two, 12.7%; three, 20.9%; four, 33.3%; and five, 50.0%. The area under the curve (AUC) for mortality based on the number of organ dysfunction was 0.88 (95% confidence interval: 0.84–0.93). The sensitivity and AUC value slightly improved after modifying the criterion for hepatic dysfunction.
Conclusions
The surveillance method effectively identified children with sepsis with high-risk of mortality and demonstrated strong discrimination of mortality. Further refinement of the method may be possible by adjusting the criteria.
Colour Transition of Flowers
Authors: K Athira , R Sajeev C. , R Jaishanker 
Published: June 2023

Abstract
Flowers are the reproductive structures of angiosperms. The floral colors of angiosperms are important to attract pollinators and convey information about the state of the plant and its environment. Colors (including floral colors) are objectively represented by three-dimensional models. The authors represent floral colors in Commission Internationale d`Eclairage (CIE) L a b model and assess its temporal drift over seven hours using (CIE ΔE) 2000. The present study measures the drift of floral colors, compares the floral colors, illustrates perceptible temporal changes in floral colors, and suggests the inclusion of time as the fourth dimension to precisely represent floral color.
Glutathione Reductase change the tumor immune microenvironment and prognosis of colon cancer：A study based on proteomic analysis
Authors: Wang Yuyao , Wu Ju , Chen Xi , Ji Rui , Zang Shuning , Nie Zhequn , Yin Jiajun 
Published: June 2023

Abstract
Background
Colonic malignant tumor cells can cause metabolic changes in the harsh microenvironment. Glutathione reductase (GSR) plays a key role in anti-oxidative stress in tumor cells, but its specific mechanism remains unclear. Therefore, the objective of this study was to investigate the prognostic value of GSR in patients with colon cancer and its effect on tumor microenvironment.
Methods
Differential proteins of colon cancer and normal intestinal tissues were obtained by proteomic differential analysis, and key proteins in metabolic pathways were identified by enrichment analysis and protein-protein interaction network (PPI) analysis. Survival analysis, immune infiltration analysis and clinical information correlation analysis were performed.
Results
A total of 1209 differentially expressed proteins were identified in 10 colon cancer samples. GO and KEGG enrichment analysis showed that differential proteins were significantly enriched in metabolic pathways, with 144 enriched genes (p < 0.05). PPI analysis showed that ADH1A, ADH1B, ADH1C, ADH5, ALDH18A1, ALDH3A1, GSTA1, GSTA2, HPGDS and GSR were the key proteins in the differential proteins metabolic pathway of colon cancer. GEPIA2 survival analysis showed that GSR significantly affected overall survival of colon cancer patients (p = 0.0017, HR = 0.45). Timer and TISIDB database analysis showed that the expression of GSR in colon cancer can significantly affect the level of immune cell infiltration. UALCAN database analysis showed that GSR expression predicted better N stage, overall stage and lower TP53 mutation rate of colon cancer (p < 0.05). The results of HPA database analysis suggested that GSR was mainly expressed in the cytoplasm and nuclear membrane of colonic malignant tumor cells.
Conclusions
Our study found that GSR plays an important role in the metabolic pathway of colon cancer and affects the prognosis of patients with statistical significance. GSR significantly affects the tumor immune microenvironment, clinical stage and TP53 mutation rate of colonic malignancies. This study provides some basis for the mechanism research and treatment of colon malignancy.