bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coronin-1 controls directional cell rearrangement inDrosophilawing epithelium
Authors: Ikawa Keisuke , Hiro Souta , Kondo Shu , Ohsawa Shizue , Sugimura Kaoru 
Published: July 2023

AbstractDirectional cell rearrangement is a critical process underlying correct tissue deformation during morphogenesis. Although the involvement of F-actin regulation in cell rearrangement has been established, the role and regulation of actin binding proteins (ABPs) in this process are not well understood. In this study, we investigated the function of Coronin-1, a WD-repeat actin-binding protein, in controlling directional cell rearrangement in theDrosophilapupal wing. Transgenic flies expressing Coronin-1-EGFP were generated using CRISPR-Cas9. We observed that Coronin-1 localizes at the reconnecting junction during cell rearrangement, which is dependent on actin interacting protein 1 (AIP1), an actin disassembler and a known regulator of wing cell rearrangement. Loss of Coronin-1 function reduces cell rearrangement directionality and hexagonal cell fraction. These results suggest that Coronin-1 promotes directional cell rearrangement via its interaction with AIP1, highlighting the role of ABPs in the complex process of morphogenesis.
Assessment of Bacteriological Quality and Associated Risk Factors of Raw Milk Marketed in Nyagatare district, Rwanda
Authors: Emmanuel Niyigena , Enock Kwizera 
Published: July 2023

ABSTRACTMilk has tremendous nutritional value for both people and animals, but because it also contains water, many different kinds of microbes can develop in it. Dairy products are still sold in both regular and unofficial marketplaces in Rwanda. Significant dangers to human health are associated with milk sold in unregulated markets. The aim of the present study was to assess the bacteriological quality and associated risk factors of raw milk marketed in Nyagatare district, Rwanda. 126 samples were collected among milk transporters from 14 sectors of Nyagatare district, Rwanda, where 9 samples were taken from each sector and analyzed in veterinary microbiology lab of University of Rwanda, Nyagatare campus. The bacterial analysis was based on carrying out total bacterial count, Coliform count, enumeration of Staphylococcus species and enumeration of Salmonella species. Milk transportes were also asked about risk factors associated with bacterial contamination of raw milk. The total bacterial count, Coliform count and enumerated Staphylococcus species had range from 7.8 × 104-80 × 104cfu/mL, 24 × 101and 80 × 101cfu/mL and 20.8 × 101and 211 × 101cfu/mL respectively and highest prevalence of Salmonella to be 1.58 %. The level of significant was not significant between various bacterial level and several risk factors except for total bacterial count and knowledge about diseases transmitted by raw milk at p < 0.05. It is, therefore, highly recommended that all concerned parties should increase awareness about diseases transmitted by raw milk among milk transporters in Nyagatare district among others.
Interventions to promote ageing in place: developing the Village model in Manchester
Authors: Doran Patty , Goff Mhorag , Phillipson Chris 
Published: July 2023

Purpose
The Village model, most extensively developed in the USA, is an innovative response to ageing populations and older adults who wish to remain living independently within their community. The “Urban Villages” participatory action research study aimed to test the potential of the Village model to work with groups of older adults in two economically deprived, inner-city neighbourhoods in Manchester, UK.

Design/methodology/approach
Participatory methods were used to work with residents to, first, adapt the Village model to the Manchester setting, and second, to develop and deliver community projects that supported ageing in place. The study aimed to involve marginalised individuals and groups in the co-design, leadership and implementation of the projects. Ethnographic methods were applied to observe and reflect on the development of “Urban Villages”. Interviews and focus groups were organised to gather the views of the residents involved in the community projects.

Findings
Residents were supported to develop and test seven projects, all aimed at reducing social isolation and supporting ageing in place. The study provides new insights into challenges related to co-production with older people in deprived neighbourhoods. These challenges are presented under the following headings: individual capacity and expectations; collective capacity including communication and knowledge; and the capacity of place.

Originality/value
To date, only a limited amount of literature is available showing how co-production with older adults can be realised when working with marginalised groups and deprived communities. The paper explores the potential of participatory approaches to develop age-friendly initiatives through strengthening the capacity of older adults to age in place.
Readiness of urban design projects for integration with big data. Case study: humanizing neighborhoods initiative—KSA
Authors: El Samaty Hosam Salah 
Published: July 2023

PurposeThe research aims at finding out the extent to which such urban transformation projects—in terms of their design components and aspects—contribute to providing big data (BD) with effective datasets, which are considered a key requirement in operating smart city solutions.Design/methodology/approachThe present research investigates the predisposition level of these projects for supporting the BD through one of the urban initiatives for humanizing neighborhoods in Al Riyadh city (KSA). The selected case is analyzed by mapping the functional performance of its design features with certain characteristics of BD.FindingsOne of the core conclusions is: Despite the readiness of the design components of these projects to provide high levels of integration with IoT and smart transformation, the level of application is lower than expected on account of the dearth of initial targets and strategies, especially the lack of a supporting environment, street facilities and security and safety datasets.Originality/valueThe answer—arrived at through both descriptive and analytical approaches—is expected to guide those who query the further key concept of smart applications—is the answer characterized as technologically based, or is the same based on human aspects?
Supporting the needs of pre‐ and primary school children in rural Victoria: Multidisciplinary views and experiences
Authors: Reid Carol , Burrows Jenny , Sprunt Robyn , Dolar Abhinay 
Published: July 2023

AbstractProblemPredicted effects on children from the COVID‐19 pandemic include poorer mental health and increased behavioural and developmental concerns. Rural children are at higher risk due to socio‐economic factors, isolation and reduced access to services. Investigation by health services into the physical, social and emotional needs of children in rural areas is critical to inform local health promotion planning, service delivery priorities and workforce capacity building.SettingLocated in a Modified Monash Model category 5, our northern Victorian health service undertook a child‐focused needs assessment in order to be strategically responsive to community issues.Key measuresThe project utilised a quantitative community profiling approach and qualitative interviews with a purposive sample (n = 17) of multidisciplinary professionals.Strategies for changeThree main themes emerged: (1) Perpetual navigation of rural access limitations highlighted professionals' exhaustion in working in environments with ongoing unmet needs. (2) Cycles of disadvantage and early intervention gaps identified flow‐on negative effects, with concerning trends in poorer child outcomes. (3) Solutions through collaboration grouped ideas to improve support for children.Effects of changeCommunity‐level enablement strategies could increase contact with allied health professionals for rural children and reduce reliance on individualised treatment approaches.Lessons learntOne collaborative action is to pilot and evaluate allied health student placement models to deliver group programs for rural children.
Lenalidomide in combination with R‐ESHAP in patients with relapsed or refractory diffuse large B‐cell lymphoma: A phase 2 study from GELTAMO
Authors: Martín García‐Sancho A. , Baile M. , Rodríguez G. , Dlouhy I. , Sancho J. M. , Jarque I. , González‐Barca E. , Salar A. , Espeso M. , Grande C. , Bergua J. , Montes‐Moreno S. , Redondo A. , Enjuanes A. , Campo E. , López‐Guillermo A. , Caballero D. 
Published: July 2023

SummaryDiffuse large B‐cell lymphoma (DLBCL) patients with relapsed or refractory (RR) disease have poor outcomes with current salvage regimens. We conducted a phase 2 trial to analyse the safety and efficacy of adding lenalidomide to R‐ESHAP (LR‐ESHAP) in patients with RR DLBCL. Subjects received 3 cycles of lenalidomide 10 mg/day on days 1–14 of every 21‐day cycle, in combination with R‐ESHAP at standard doses. Responding patients underwent autologous stem‐cell transplantation (ASCT). The primary endpoint was the overall response rate (ORR) after 3 cycles. Centralized cell‐of‐origin (COO) classification was performed. Forty‐six patients were included. The ORR after LR‐ESHAP was 67% (35% of patients achieved complete remission). Patients with primary refractory disease (n = 26) had significantly worse ORR than patients with non‐refractory disease (54% vs. 85%, p = 0.031). No differences in response rates according to the COO were observed. Twenty‐eight patients (61%) underwent ASCT. At a median follow‐up of 41 months, the estimated 3‐year PFS and OS were 42% and 48%, respectively. The most common grade ≥3 adverse events were thrombocytopenia (70% of patients), neutropenia (67%) and anaemia (35%). There were no treatment‐related deaths during LR‐ESHAP cycles. In conclusion, LR‐ESHAP is a feasible salvage regimen with promising efficacy results for patients with RR DLBCL.
Controls on sedimentation in a deep‐water foredeep: Central Pindos foreland basin, western Greece
Authors: Botziolis Chrysanthos , Maravelis Angelos G. , Catuneanu Octavian , Zelilidis Avraam 
Published: July 2023

AbstractThis study provides a sedimentological, stratigraphic and palaeocurrent investigation of Upper Eocene to Lower Oligocene deep‐sea fan deposits found in the central part of the Pindos foreland basin in western Greece. According to facies analysis, the examined succession at Amfilochia area has 13 sedimentary facies and 10 facies and sub‐facies associations. Depositional elements include abyssal plain pelagics, outer fan, inner fan, and slope deposits. Outer fan sediments are classified as lobe‐axis, lobe‐off‐axis, lobe‐fringe, and distant lobe‐fringe deposits, while inner fan sediments are classified as channel‐fill, crevasse‐splay, internal and external levee deposits. The stratigraphic study shows an upward shift from abyssal plain pelagics to outer, inner fan, and finally slope deposits, implying submarine fan system progradation and progressive infilling of a deep‐water sediment depocentre. The sediments were deposited in the foredeep of the Pindos foreland system and correspond to the system's underfilled stage, when sedimentation was unable to exceed the accommodation provided by lithospheric flexure. They point to deposition near the onset of the Pindos orogen, after the closure of the Pindos basin because of the collision of the Apulian with the Pelagonian microplate during the Cretaceous‐Palaeogene period. Palaeocurrent data from sole marks show bipolar directions associated with two distinct spreading sub‐marine fan deposits. As a result, the study region was split into Upper (major SE‐direction flow) and Lower (major NW‐direction flow) parts, indicating that axial flows were predominant during sediment deposition. However, as the deposition of the elements continued, the progradation of both systems constrained the space accommodation because of the increased basin sediment supply and forced an increase in the degree of basin confinement that changed the compensational to aggradational stacking pattern. The goals of this research are to develop an updated facies model for these deep‐sea fans as well as a robust correlation framework for the various stratigraphic units in the central Pindos foreland basin. This research also connects the stratigraphic development of deep‐sea fan deposits to the evolutionary phases of the Pindos foreland system, providing fresh insights into the palaeogeographic circumstances in the Pindos foreland basin.
Phototherapy: Theory and practice
Authors: Kurz Bernadett , Berneburg Mark , Bäumler Wolfgang , Karrer Sigrid 
Published: July 2023

SummaryDespite the development of highly effective biologics for skin diseases such as psoriasis or atopic dermatitis, UVA and UVB therapy, alone or in combination, are still essential components of various guidelines. Phototherapy is not only a first‐line treatment and highly effective for a number of skin diseases, but is also economical and has few side effects. The targeted use of UVA and UVB, if necessary, in combination with the photosensitizer psoralen in the context of PUVA therapy, enables the dermatologist to effectively treat a wide variety of skin diseases. Indications for phototherapy include epidermal diseases such as atopic dermatitis, psoriasis and vitiligo, as well as photodermatoses, mycosis fungoides, graft‐versus‐host disease and deep dermal diseases such as scleroderma. This article reviews the physical principles, molecular mechanisms, current treatment regimens, and individual indications for phototherapy and photochemotherapy.
Concomitant medication in patients with bradykinin‐mediated angioedema – there's more than ACE inhibitors
Authors: Lochbaum Robin , Hoffmann Thomas K. , Greve Jens , Hahn Janina 
Published: July 2023

SummaryBradykinin‐mediated angioedema is a rare, non‐allergic, potentially life‐threatening disease. ACE inhibitor‐induced angioedema and hereditary angioedema (HAE) are the two most common presentations. Therapeutic options, pathophysiology and diagnosis continue to be investigated, with considerable progress in HAE over the last few decades. For all patients with bradykinin‐mediated angioedema, there are several medications that should be avoided or administered with caution. Some of the triggering medications are well known, while others are suspected or of unknown significance. A common denominator is that there is no approved therapy for bradykinin‐mediated angioedema as a drug side effect. Some medications, such as tissue plasminogen activator, have a higher incidence of angioedema with potential airway compromise than ACE inhibitors, although this fact is widely underappreciated. In this review, we aim to summarize what is currently known and recommended about concomitant medication in HAE patients and the interaction of other bradykinin‐influencing drugs.
Hypoglycaemia induces a sustained pro‐inflammatory response in people with type 1 diabetes and healthy controls
Authors: Verhulst Clementine E. M. , van Heck Julia I. P. , Fabricius Therese W. , Stienstra Rinke , Teerenstra Steven , McCrimmon Rory J. , Tack Cees J. , Pedersen‐Bjergaard Ulrik , de Galan Bastiaan E. ,   the Hypo‐RESOLVE consortium
Published: July 2023

AbstractAimTo determine the duration and the extension of the pro‐inflammatory response to hypoglycaemia both in people with type 1 diabetes and healthy controls.Materials and MethodsAdults with type 1 diabetes (n = 47) and matched controls (n = 16) underwent a hyperinsulinaemic‐euglycaemic hypoglycaemic (2.8 ± 0.1 mmoL/L [49.9 ± 2.3 mg/dL]) glucose clamp. During euglycaemia, hypoglycaemia, and 1, 3 and 7 days later, blood was drawn to determine immune cell phenotype, monocyte function and circulating inflammatory markers.ResultsHypoglycaemia increased lymphocyte and monocyte counts, which remained elevated for 1 week. The proportion of CD16+ monocytes increased and the proportion of CD14+ monocytes decreased. During hypoglycaemia, monocytes released more tumour necrosis factor‐α and interleukin‐1β, and less interleukin‐10, after ex vivo stimulation. Hypoglycaemia increased the levels of 19 circulating inflammatory proteins, including high sensitive C‐reactive protein, most of which remained elevated for 1 week. The epinephrine peak in response to hypoglycaemia was positively correlated with immune cell number and phenotype, but not with the proteomic response.ConclusionsOverall, despite differences in prior exposure to hypoglycaemia, the pattern of the inflammatory responses to hypoglycaemia did not differ between people with type 1 diabetes and healthy controls. In conclusion, hypoglycaemia induces a range of pro‐inflammatory responses that are sustained for at least 1 week in people with type 1 diabetes and healthy controls.
Successful surgical management of a single coronary artery with giant coronary artery aneurysm with fistula to the right ventricle
Authors: Chen Mei , Wang Jue , Ye Teng , Liu Jinjin , Liao Shusheng 
Published: July 2023

AbstractA giant coronary artery aneurysm (GCAA) concurrent with coronary artery fistula is a rare condition, and it becomes even more unusual when combined with a single coronary artery (SCA) anomaly. Here, we report such an extremely rare case, who is a 35‐year‐old woman presenting with severe chest distress. A GCAA with fistula to the right ventricle was noted, occurring in a single coronary artery, diagnosed by multimodality cardiovascular imaging techniques. Both GCAA and coronary artery fistula can cause severe cardiac complications, which jeopardize life. While an SCA is mostly asymptomatic, it may also lead to sudden cardiac death as well. Therefore, surgical intervention was recommended. We chose a novel thrombus‐inducing strategy to eliminate the GCAA and repair the fistula. Symptoms were relieved after the surgery, and the patient remained asymptomatic over 8 months of follow‐up.
Progressive multifocal leukoencephalopathy in a patient with relapsing multiple sclerosis treated with ocrelizumab: A case report
Authors: Puig‐Casadevall Marc , Álvarez‐Bravo Gary , Varela Ana Quiroga , Robles‐Cedeño René , Sànchez Cirera Laura , Miguela Albert , Laguillo Gemma , Montalban Xavier , Hauser Stephen L. , Ramió‐Torrentà Lluis 
Published: July 2023

AbstractIntroductionProgressive multifocal leukoencephalopathy is a rare but often fatal complication of some multiple sclerosis treatments. Although it has mainly been associated with natalizumab treatment, its appearance with other immunosuppressive therapies has also been reported.AimsThe aim of this case report is to describe the development of progressive multifocal encephalopathy in a patient with relapsing–remitting multiple sclerosis treated with ocrelizumab without previous use of natalizumab.ConclusionsA summary of the presentation and disease course is provided, presented in the context of the current literature and likely pathophysiology.
HLA‐A*02:06 allele may be susceptible to myelodysplastic syndrome in Zhejiang Han population, China
Authors: Chen Nanying , Wang Fang , Zhao Yanmin , Dong Lina , Wang Wei , Zhang Wei , He Ji , Zhu Faming 
Published: July 2023

AbstractThe association between HLA loci and haematological malignancy has been reported in certain populations. However, there are limited data for HLA loci at a high‐resolution level with haematological malignancy in China. In this study, a total of 1115 patients with haematological malignancies (including 490 AML, 410 acute lymphoblastic leukaemia (ALL), 122 myelodysplastic syndrome [MDS] and 93 non‐Hodgkin's lymphoma [NHL]) and 1836 healthy individuals as a control group in the Han population of Zhejiang Province, China, were genotyped for HLA‐A, HLA‐C, HLA‐B, HLA‐DRB1 and HLA‐DQB1 loci at high resolution. The possible association between HLA alleles and haplotypes and haematologic malignancy was analysed. The allele frequencies (AFs) of HLA‐A*02:05, HLA‐A*02:06, HLA‐A*32:01, HLA‐B*35:03, HLA‐B*54:01, HLA‐B*55:07, HLA‐DRB1*04:05, HLA‐DRB1*15:01, HLA‐DQB1*04:01 and HLA‐DQB1*06:02 in the MDS patients were much higher than those in the control group (P < 0.05), while the AFs of HLA‐C*07:02, HLA‐DRB1*03:01, HLA‐DRB1*14:54, HLA‐DQB1*02:01 and HLA‐DQB1*05:03 were obviously lower than those in the control group (p < .05). Interestingly, the differences in these HLA alleles in patients with MDS were not significant after applying Bonferroni correction (Pc > .05), except for HLA‐A*02:06 (Pc < .01). There were 13, 6 and 10 HLA alleles with uncorrected significant differences (p < .05) among patients with AML, ALL and NHL, respectively, compared with those in the control group, but the differences in these HLA alleles were not significant after correction (Pc > .05). Compared to those of the control group, there were some haplotypes over 1.00% frequency in patients with AML, MDS and NHL patients with uncorrected significant differences (p < .05). However, none of them showed a significant difference after correction as well (Pc > .05). The study reveals that HLA‐A*02:06 may lead to susceptibility to MDS, but none of the HLA alleles were associated with AML, ALL or NHL after correction. These data will help to further understand the role of HLA loci in the pathogenesis of haematological malignancy in China.
Embedding Physical Activity Guidance During Pregnancy and in Postpartum Care: ‘This Mum Moves’ Enhances Professional Practice of Midwives and Health Visitors
Authors: Taylor Katrina Ann , De Vivo Marlize , Mills Hayley , Hurst Phil , Draper Stacey , Foad Abby 
Published: July 2023

IntroductionThe benefits of physical activity during pregnancy and after childbirth are well established, yet many health care professionals do not feel well equipped to provide physical activity guidance to these populations. As such, the objectives of this study were to explore the immediate and longer term effects of training on health care professionals’ ability to provide physical activity guidance to pregnant women and new mothers (mums).MethodsMidwives and health visitors from 5 locations in the United Kingdom were provided with training on the Chief Medical Officers' physical activity guidelines for pregnancy and after childbirth (n = 393). Midwives and health visitors attended training to become This Mum Moves Ambassadors, then disseminated education to colleagues through a cascade training model. Changes in knowledge, confidence, and professional practice were assessed by survey before and immediately after training (n = 247), and follow‐up surveys were completed 3 (n = 35) and 6 (n = 34) months posttraining.ResultsAt all posttraining time points, health care professionals reported a significant increase in their confidence to communicate about physical activity (P < .001). The reported frequency of having conversations about physical activity increased significantly 3 and 6 months following training compared with baseline (pregnant women, P = .017; new mums, P = .005). There were changes in the types of advice and resources offered by health care professionals and an overall increase in health care professionals’ own reported physical activity levels.DiscussionThe This Mum Moves cascade approach to delivering training in physical activity guidelines improved reported knowledge, confidence and professional practice of midwives and health visitors, both immediately following and 3 and 6 months after training.