bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Surveillance Capitalism Trigger the Financial Performance of Information Technology Firms? A Reflection from FAANG Business Models
Authors: Biju A V , Aparna A S , Treesa Jency , Nikhil N K 
Published: March 2023

Abstract

This paper maps the idea of surveillance capitalism of FAANG (Facebook, Apple, Amazon, Netflix, and Google), which have capitalised on the behavioural surplus accumulated in their databases and how they utilise this data for future business models. The fundamental research question is how the data-driven models trigger these companies’ future financial performance and ensure sustainable growth. A triangulation approach was used to observe the world of surveillance capitalism through multiple lenses. The relative valuation models were used to substantiate the exponential growth of FAANG companies from 2006 to 2020. Financial indicators like the EPS, ROE, Market Capitalization and ROA were used to capture the growth of FAANG. Our undertaking shows that FAANG earns substantial revenue through data-driven business models catalysing the present companies' growth. This paper also illuminates the nudging effect created by behaviour-centric advertisements, which results in the brand value appreciation of FAANG. The article can be seen as a novel attempt as it empirically proves that FAANG has grown faster due to the power of surveillance capitalism.
JEL Code: A130; O330: O380: K420
Colored-Sticky paper trapability of periurban population of sand flies (Diptera: Psychodidae)
Authors: Ahmed Tasneem , Ali Mayada , Ismail Ibrahim , Ahmed Khalid , Karamalla Lubna , Mohamed Yassir 
Published: March 2023

Abstract
Background: Sand flies are the natural vectors of humans leishmaniasis a neglected disease, yet universally endemic in 98 countries with 350 million people at risk. Though significant advancements have been made in developing therapeutics attack on the vectors is anticipated to be a promising approach for controlling the vectors and the disease. Hence the current study was carried out to provide accurate data required for execution of successful control of local sand flies population.
Mehtods: The randomized Latin square technique was used to determine the aparnt effeicency and performance of colored sticky paper traps in order to establish an effective sampling and controling system.
Results: The white, yellow and green colored sticky paper traps were found to be significantly more attractive and effective than red and blue colored ones to the local sand flies population.
Conclusion: The trap color was the source of captured variation observed. White and yellow sampling system was suggested for clarifying sand fly population under quantitative studies to generate information necessary for carrying out successful control as they captured the efficient leishmaniasis vectors P. papatasi and P. orientalis though prevalent in low densities.
The Molecular Mechanism of Scutellaria Barbata Flavonoids in Promoting Neurogenesis and Improving Memory Impairment Mediated by CREB Phosphorylation in Rats
Authors: Liu Xinyang , Liu Yuling , Cheng Jianjun , Gao Yang , Zhao Chunying , Ma Shuai , Li Caixia , Shang Yazhen 
Published: March 2023

Abstract
Background
The present study was aimed to investigate the effect and molecular mechanism of Scutellaria barbata flavonoids (SBFs) in promoting neurogenesis and improving memory impairment mediated by CREB phosphorylation in rats.
Methods
Alzheimer’s disease (AD) model was established by intracerebroventricular injection of amyloid beta-peptide 25–35 (Aβ25−35) in combination with aluminum trichloride (AlCl3) and recombinant human transforming growth factor-β1 (RHTGF-β1) (composited Aβ) in rats. The Morris water maze was used to screen the successful AD model of rats. The screened successful AD model rats were randomly divided into three groups including a model group and two drug groups of 140 mg/kg SBFs and 0.5 mg/kg Rolipram (Positive control drug). After administration for 38 days, the Morris water maze test was used to measure the learning and memory ability of the rats. HE staining was used to observe the morphology of neurons in the hippocampus and cerebral cortex regionsof the rats' brains. Immunohistochemistry was used to detect the expression of NeuN in the hippocampal gyrus of rats. The mRNA expression of TrkB, RSK,CREB, and BDNF and the protein expression of NeuN, TrkB, RSK, P-CREB-Ser133, and BDNF in the hippocampus and cerebral cortex of the rats were assayed by quantitative real-time PCR (qPCR) and Western blotting methods.
Results
Intracerebroventricular injection of composited Aβ induced memory impairment, impaired neurons, decreased the protein expression of NeuN in the hippocampal gyrus, increased the mRNA expression levels of TrkB, RSK and BDNF, decreased the mRNA expression level of CREB and the protein expression levels of NeuN, TrkB, RSK, P-CREB-Ser133 and BDNF in the hippocampus and cerebral cortex of rats. However, SBFs attenuated memory impairment which was induced by composited Aβ in rats and ameliorated neuropathological changes in the brain, increased the expression of NeuN protein in the hippocampal gyrus, and regulated mRNA and protein expressions in composited Aβ treated rats. Rolipram ameliorated learning and memory disorder induced by composited Aβ, increased the protein expression of P-CREB-Ser133, increased the expression of NeuN protein in the hippocampal gyrus, promoted neurogenesis, and improved the neuropathological changes in the brain. The effect of SBFs was also similar to Rolipram.
Conclusion
The effect of SBFs was consistent with the positive control drug Rolipram. SBFs could promote neurogenesis and improve learning and memory impairment in AD rats, and its mechanism was mediated by CREB phosphorylation.
Combined of favorite cartoon stickers and fruit juices to reduce premedication anxiety in preschool children in the absence of parents
Authors: Liu Ting , Wang Dan , Wang Yanting , Tao Yingying , Zhu Ming , Zhang Mazhong , Sun Ying , Peng Zhezhe 
Published: March 2023

Abstract
Background

Several initiatives had been promoted to largely reduce transmission during the new coronavirus disease 2019 (COVID-19) World Pandemic. However, children's preoperative anxiety was more prominent when parents were advised not to stay with their children in the preoperative holding area. This study aimed to determine whether combined of favorite carton stickers and fruit juices could reduce premedication anxiety in preschool children who lacked parental presence and were scheduled for elective surgery.

Methods

One hundred and fourteen healthy children, aged 3–6 years, assigned to elective surgery were randomized to one of three groups: Group A (a cartoon noggin), Group B (a cartoon noggin and cartoon stickers), Group C (a cartoon noggin, cartoon stickers, and fruit juices). All groups routinely received sedative premedication (oral midazolam, 0.5mg/kg) before anesthesia induction. The modified Yale Preoperative Anxiety Scale-Short Form (mYPAS-SF) was used to evaluate the anxiety of each child in the following time points: T0 (baseline anxiety: immediately after arriving in the preoperative holding area), T1 (3 min after the interventions), T2 (at the time of midazolam oral administration).

Results

There was no significant difference in mYPAS-SF scores among the three groups at T0 (P = 0.174). Children in Group C manifested significantly lower mYPAS-SF scores at T1 compared with Group A and Group B (P < 0.001 and P = 0.012), and T2 (P < 0.001 vs both groups). Subjects in Group B showed lower mYPAS-SF scores than that in Group A at T1 (P = 0.008) and T2 (P = 0.009).

Conclusions

Cartoon stickers for reducing premedication anxiety were effective, besides, the combination of cartoon stickers and fruit juices was found to be a profitable tool to reduce premedication anxiety in preschool children undergoing elective surgery.
Clinical Trial Registry: A one-month, open-label study to evaluate the effect of the combination of favorite carton stickers and fruit juices on preschool children who suffer premedication anxiety.
(https://www.chictr.org.cn/showproj.aspx?proj=185586) Registration number: ChiCTR2200066644.
The site of origin of medulloblastoma: Does the neurosurgical perspective support the current concept from molecular data?
Authors: Ciobanu-Caraus Olga , Kasprian Gregor , Furtner Julia , Kool Marcel , Sill Martin , Frischer Josa M. , Cho Anna , Peyrl Andreas , Haberler Christine , Slavc Irene , Czech Thomas , Rössler Karl , Gojo Johannes , Dorfer Christian 
Published: March 2023

Abstract
Purpose Developmental gene expression data from medulloblastoma (MB) supported by retrospective MR imaging studies suggest that WNT-MB originate from the region of the embryonic lower rhombic lip (LRL), whereas SHH-MB and non-WNT/non-SHH-activated MB arise from cerebellar precursor matrix regions. This study aims to analyze detailed intraoperative data with regard to the site of origin (STO) and compare these findings with the hypothesized regions of origin associated with the molecular group.
Methods A review of the institutional database identified 58 pediatric patients who were operated on a MB at our department between 1996 and 2020 and had a detailed operative report, surgical video as well as clinical and genetic classification data available for analysis. The STO was assessed based on intraoperative findings of an expert neurosurgeon blinded to the molecular group information.
Results Using the intraoperatively defined STO, “correct” prediction of molecular groups was feasible in 20% of WNT-MB, 60% of SHH-MB and 71% of non-WNT/non-SHH activated MB. The positive predictive values of the neurosurgical inspection to detect the molecular group were 0.21 (95% CI 0.08–0.48) for WNT-MB, 0.86 (95% CI 0.49–0.97) for SHH-MB and 0.73 (95% CI 0.57–0.85) for non-WNT/non-SHH activated MB.
Conclusions The present study demonstrated a limited predictive value of the intraoperatively observed STO for the prediction of the molecular group of MB. Thus, our findings challenge the current concept of the molecular group-specific origins based on developmental gene expression data and neuroradiological STO definitions.
Using Personalized Next Session to Improve Session-Based Recommender Systems
Authors: Chen Yen-Liang , Wu Chia-Chi , Shih Po-Cheng 
Published: March 2023

Abstract
In e-commerce, session-based personalized recommendation is still a challenging task due to the limited information of users in a session. Therefore, it is not enough to include only the user's local information. Instead, we should consider global information, i.e., extract information from all users' sessions to explore more collaborative information. However, using all session information will waste computing resources, and there will be a lot of information in the global information that is not relevant to the current user, which will damage the correctness of the prediction. Therefore, instead of referencing all global information, we select only those sessions that are useful to users, the so-called Personalized Next Session (PNS), as global information to improve the lack of local information. This work is the first to adopt a deep network architecture study incorporating the concept of PNS to recommend the next item of the current session to the user. We have conducted experiments on several real-world datasets. Extensive experimental results show that our proposed deep network architecture outperforms state-of-the-art recommendation methods.
WITHDRAWN: Bortezomib in PTEN-deficient patients with advanced intrahepatic cholangiocarcinoma: an open-label, prospective, phase II trial
Authors: zeng tianmei , Jiang Tian-yi , Yang Guang , Cheng Zhuo , Lou Cheng , Wei Wei , Tao Chen-jie , Hu Shouzi , Wang Hui , Cui Xiao-wen , Tan Ye-xiong , Dong Li-wei , Wang Hong-yang , Yuan Zhen-gang 
Published: March 2023

Abstract
Background: Intrahepatic cholangiocarcinoma (ICC) is characterized by a dismal prognosis with limited therapeutic options. To explore phosphatase and tension homology deleted on chromosome ten (PTEN) as a biomarker for proteasome inhibition in ICC, we conducted a phase II trial to assess the second line efficacy of bortezomib in PTEN-deficient advanced ICC patients.
Methods: Between July 1, 2017, and June 30, 2021, a total of 130 patients with advanced ICC were screened by PTEN immunohistochemical staining and 16 patients were enrolled. Patients with PTEN deficiency who had progressed after gemcitabine combined cisplatin received single-agent bortezomib 1.3 mg/m2 on days 1, 4, 8, and 11 of a 21-day cycle. The primary endpoint was objective response rate (ORR) according to Response Evaluation Criteria in Solid Tumors v1.1.
Results: The median time of follow up was 4.63 months (95% CI: 0.7~17.2 months). Among the 16 enrolled patients, 13 of them had completed treatment with bortezomib at least 2 cycles and been evaluated. The ORR was 23% (3/13) and disease control rate was 54% (7/13). The median progress-free survival (mPFS) was 2.95 months (95% CI: 2.1~5.1 months) and the median overall survival (mOS) was 7.2 (95% CI: 0.7~21.6 months) months in the intent-to-treat patients. Treatment-related adverse events of any grade were reported in 16 patients, with thrombopenia being the most common toxicity. Patients with PTEN staining score of 0 were more likely to benefit from bortezomib than those with staining score > 0.
Conclusions: Bortezomib yielded encouraging objective response and a favorable overall survival as a second-line therapy in PTEN-deficient ICC patients. Our findings suggest bortezomib as a promising treatment option in selected ICC patients with PTEN deficiency.
Trial Registration: ClinicalTrials.gov (NCT03345303).
TLR1-N248S polymorphism Reduces the Therapeutic Efficacy of Chemotherapy by Attenuating Antitumor Immunity in Locally Advanced Colorectal Cancer
Authors: Huang Kevin Chih-Yang , Ke Tao-Wei , Chen Chia-Yi , Chiang Shu-Fen , Hong Wei-Ze , Lai Chia-Ying , Chen Tsung-Wei , Yang Pei-Chen , Liang Ji-An , Chen William Tzu-Liang , Chao K. S. Clifford 
Published: March 2023

Abstract
Regional lymph nodes metastasis is an important predictor for survival outcome and the indicator for postoperative adjuvant chemotherapy in patients with colorectal cancer (CRC) patient. Even the advance in the adjuvant chemotherapeutic regimen, the 5-year distant metastasis and survival are still unsatisfied. Here, we evaluate the clinical significance of single-nucleotide polymorphisms on TLR1 and TLR2, which are the receptors for HMGB1 that is the hallmark for immunogenic cell death (ICD), in patients with stage II-III colon carcinoma (COAD). We found patients with high cytosolic HMGB1 are associated with survival outcome in stage III COAD patients who received adjuvant chemotherapy. Moreover, patients with TLR1-N248S polymorphism (rs4833095) may influence the therapeutic efficacy of adjuvant chemotherapy, suggesting TLR1-N248S is an independent prognostic factor for locally advanced colon carcinoma patients. Moreover, patient bearing TLR1-N248S polymorphism had high risk of distant metastasis after first-line adjuvant chemotherapeutic regimen with 5 year by multivariate COX analysis [HR=1.694, 95%CI=1.063-2.698, p=0.027]. We found that defective TLR1 impaired TLR1/2 signaling on dendritic cells (DCs) maturation for antitumor immune response under immunogenic chemotherapy oxaliplatin (OXP) treatment. Defective TLR1 on DCs impaired its maturation ability by HMGB1 and reduced the secretion of IFN from T cells to eradicate the residual tumor cells in vitro. Moreover, systemic inhibition of TLR1/2 dramatically reduced the tumor-infiltrating immune cells by OXP treatment, leading to poor therapeutic response to OXP. On the contrary, administration with TLR1/2 agonist synergistically increased the benefit of OXP treatment and triggered high density of tumor-infiltrating immune cells. We also observed that less tumor-infiltrating cytotoxic T lymphocyte was located within tumor microenvironment in patients bearing TLR1-N248S polymorphism. Taken together, these results showed that patients bearing TLR1-N248S polymorphism might reduce the therapeutic response to adjuvant chemotherapy by attenuating antitumor immune response via impairing HMGB1-mediated DC maturation in locally advanced colon carcinoma patients.
How different is different? Systematically identifying distribution shifts and their impacts in NER datasets
Authors: Li Xue , Groth Paul 
Published: March 2023

Abstract

When processing natural language, we are frequently confronted with the problem of distribution shift. For example, using a model trained on a news corpus to subsequently process legal text exhibits reduced performance. While this problem is well-known, to this point, there has not been a systematic study of detecting shifts and investigating the impact shifts have on model performance for NLP tasks. Therefore, in this paper, we detect and measure two types of distribution shift, across three different representations, for 12 benchmark Named Entity Recognition datasets. We show that both input shift and label shift can lead to dramatic performance degradation. For example, fine-tuning on a wide spectrum dataset (Ontonotes) and testing on an email dataset (Cerec) that shares labels leads to a 63-points drop in F1 performance. Overall, our results indicate that the measurement of distribution shift can provide guidance to the amount of data needed for fine-tuning and whether or not a model can be used "off-the-shelf" without subsequent fine-tuning. Finally, our results show that shift measurement can play an important role in NLP model pipeline definition.
An exploration into the causal relationships between educational attainment, intelligence, and wellbeing: an observational and two-sample Mendelian randomisation study
Authors: Armitage J. M , Wootton R.E , Haworth C.M.A , Davis O.S.P. 
Published: March 2023

Abstract
Educational attainment is associated with a range of positive outcomes, yet its impact on wellbeing is unclear, and complicated by high correlations with intelligence. We use genetic and observational data to investigate for the first time, whether educational attainment and intelligence are causally and independently related to wellbeing. Results from our multivariable Mendelian randomisation demonstrated a positive causal impact of educational attainment on wellbeing that remained after accounting for intelligence, and a negative impact of intelligence that was independent of educational attainment. Observational analyses suggested that these associations may be subject to sex differences, with benefits to wellbeing greater for females who attend higher education compared to males. For intelligence, males scoring more highly on measures related to happiness were those with lower intelligence. Our findings demonstrate a unique benefit for wellbeing of staying in school, over and above improving cognitive abilities, with benefits likely to be greater for females compared to males.
Protective Effects of Grape Seed Procyanidin Extract on Fluoride-Induced nephrotoxicity and the possible role of Nrf2 signaling pathway
Authors: Wang Er Hui , Ping Guan Fang , Bu Yong Jun 
Published: March 2023

AbstractTo investigate effects of fluoride-induced renal damage and possible role of the Nrf2 signaling pathway and explore the protective activity of Grape Seed Procyanidin Extract (GSPE). A fluoride-exposed rat model was established through drinking water. Oxidative stress parameters and serum markers that reflect renal function were analyzed. Pathological changes were assessed using HE and TUNEL methods. Nrf2 signaling pathway-related and apoptosis-related cleaved Caspase-3 proteins were detected by Western blot. Fluoride exposure caused a significant increase in serum markers of renal function, renal histopathological alterations, oxidative stress, and apoptosis. The protein expression levels of Nrf2, HO-1, and NQO-1 along the Nrf2 signaling pathway were depressed, while the cleaved Caspase-3 protein were upregulated after fluoride exposure. HE and TUNEL examination showed that the renal tissue of fluoride rats was repaired by GSPE. The level of MDA was decreased; while the level of GSH, activities of CAT, and SOD of the kidney were promoted by GSPE. Decreased serum markers such as BUN, UA, and Cr indicate a marked improvement in renal function. GSPE therapy up-regulated the expression levels of Nrf2, HO-1, NQO-1 and down-regulated cleaved Caspase-3 proteins in the kidney. Supplementary GSPE with fluoride significantly alleviated its nephrotoxicity. The results above mentioned indicated that fluoride induced nephrotoxicity possibly through activate the Nrf2 signaling pathway and the presence of GSPE mitigate its nephrotoxicity.
Design and Realization of Void-centric Zone Plate Ultrasonic Transducer: Considering Structural Vibration of Piezoelectric Metamaterials
Authors: Sim Min-Jung , Elmina Bernadette , Kim Sung Mok , Baik Kyungmin , Kim Yong 
Published: March 2023

Abstract
We developed and experimentally realized a novel type of focal transducer called a void-centric zone plate ultrasonic transducer (VZPUT). Although VZPUT is a planar transducer, it can focus ultrasound and control the focal length using a single-channel electric network. Further, unlike a classical Fresnel zone plate, the VZPUT has space for an imaging probe at the center, making it useful for therapeutic focused ultrasound (FUS). To realize VZPUT, we develop a novel void-centric zone plate (VZP) that allows design freedom for the radius of the space at the center. Then, we fabricate the piezoelectric VZP, an acoustic metamaterial, considering its structural vibration modes that appear within the operating frequency range. The VZPUT demonstrated applicability to therapeutic FUS in that it could control the focal point by the operating frequency with real-time monitoring images from the imaging probe mounted at the center.