bluuebunny/crossref_metadata_2025_split huggingface dataset:
INKILN
is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10
Authors: Zhang Wei , Zhao Jinjing , Deng Lin , Ishimwe Nestor , Pauli Jessica , Wu Wen , Shan Shengshuai , Kempf Wolfgang , Ballantyne Margaret D. , Kim David , Lyu Qing , Bennett Matthew , Rodor Julie , Turner Adam W. , Lu Yao Wei , Gao Ping , Choi Mihyun , Warthi Ganesh , Kim Ha Won , Barroso Margarida M. , Bryant William B. , Miller Clint L. , Weintraub Neal L. , Maegdefessel Lars , Miano Joseph M. , Baker Andrew H , Long Xiaochun 
Published: May 2023

Background:
Activation of vascular smooth muscle cell (VSMC) inflammation is vital to initiate vascular disease. The role of human-specific long noncoding RNAs in VSMC inflammation is poorly understood.

Methods:

Bulk RNA sequencing in differentiated human VSMCs revealed a novel human-specific long noncoding RNA called inflammatory MKL1 (megakaryoblastic leukemia 1) interacting long noncoding RNA (
INKILN
).
INKILN
expression was assessed in multiple in vitro and ex vivo models of VSMC phenotypic modulation as well as human atherosclerosis and abdominal aortic aneurysm. The transcriptional regulation of
INKILN
was verified through luciferase reporter and chromatin immunoprecipitation assays. Loss-of-function and gain-of-function studies and multiple RNA–protein and protein–protein interaction assays were used to uncover a mechanistic role of
INKILN
in the VSMC proinflammatory gene program. Bacterial artificial chromosome transgenic mice were used to study
INKILN
expression and function in ligation injury–induced neointimal formation.

Results:

INKILN
expression is downregulated in contractile VSMCs and induced in human atherosclerosis and abdominal aortic aneurysm.
INKILN
is transcriptionally activated by the p65 pathway, partially through a predicted NF-κB (nuclear factor kappa B) site within its proximal promoter.
INKILN
activates proinflammatory gene expression in cultured human VSMCs and ex vivo cultured vessels.
INKILN
physically interacts with and stabilizes MKL1, a key activator of VSMC inflammation through the p65/NF-κB pathway.
INKILN
depletion blocks interleukin-1β–induced nuclear localization of both p65 and MKL1. Knockdown of
INKILN
abolishes the physical interaction between p65 and MKL1 and the luciferase activity of an NF-κB reporter. Furthermore,
INKILN
knockdown enhances MKL1 ubiquitination through reduced physical interaction with the deubiquitinating enzyme USP10 (ubiquitin-specific peptidase 10).
INKILN
is induced in injured carotid arteries and exacerbates ligation injury–induced neointimal formation in bacterial artificial chromosome transgenic mice.

Conclusions:

These findings elucidate an important pathway of VSMC inflammation involving an
INKILN
/MKL1/USP10 regulatory axis. Human bacterial artificial chromosome transgenic mice offer a novel and physiologically relevant approach for investigating human-specific long noncoding RNAs under vascular disease conditions.
Globalization and Islamic Music (Asalatu) in Nigeria
Authors: Akanle Olayinka , Omoniyi O. 
Published: May 2023

Abstract
This article explores Asalatu, a form of Islamic music among Yoruba Muslims in Nigeria, against the backdrop of globalization and the impact of Western music. The article points to observed changes in the music and musical possibilities within increasing secularization. Drawing on ethnographic data, the article illuminates tangential issues such as the use of the mother tongue for Islamic music as opposed to Arabic, and the introduction of dance to Islamic music to account for the changes. The article is a major contribution to knowledge in the fields of religion in Africa, Islamic studies, and popular/material culture. Globalization has closely knit nations together such that there is an acceleration of the integration of nations into the global system. Accounting for changes in Islamic music as a result of globalization helps provide insights into the nature of society, whether increasingly religious or secular.
From the Margins of the Field or the Midan
Authors: Wahba Dina 
Published: May 2023

Abstract
This article introduces the concept of the affective register of the 2011 Egyptian Revolution that captures three affective states. Namely: (1) The making of ‘The People’ in the famous slogan, “The people demand the downfall of the regime”. An affective state that reflects the coming together of people from diverse political backgrounds, religious affiliations, socio-economic classes, and across the classic gender divide, not just as materiality, but also as a feeling expressed by many. (2) The breaking of fear, and (3) the expansion of political imaginaries of the possible in a repressive postcolonial state. Empirically, the article explores the narrative of Gerges who was 22 during the revolution, a Coptic young man from the popular neighborhood of Shubra in Cairo to tell the story of the Midan from its margins. The article details his participation in the revolution, how he experienced the Midan, and what he witnessed in Shubra as people started attacking police stations and tried to enact their version of street justice.
Impact-Based Flood Early Warning for Rural Livelihoods in Uganda
Authors: Mitheu Faith , Stephens Elisabeth , Petty Celia , Ficchì Andrea , Tarnavsky Elena , Cornforth Rosalind 
Published: May 2023

Abstract
Anticipatory actions are increasingly being taken before an extreme flood event to reduce the impacts on lives and livelihoods. Local contextualized information is required to support real-time local decisions on where and when to act and what anticipatory actions to take. This study defines an impact-based, early-warning trigger system that integrates flood forecasts with livelihood information, such as crop calendars, to target anticipatory actions better. We demonstrate the application of this trigger system using a flood case study from the Katakwi District in Uganda. First, we integrate information on the local crop cycles with the flood forecasts to define the impact-based trigger system. Second, we verify the impact-based system using historical flood impact information and then compare it with the existing hazard-based system in the context of humanitarian decisions. Study findings show that the impact-based trigger system has an improved probability of flood detection compared with the hazard-based system. There are fewer missed events in the impact-based system, while the trigger dates are similar in both systems. In a humanitarian context, the two systems trigger anticipatory actions at the same time. However, the impact-based trigger system can be further investigated in a different context (e.g., for livelihood protection) to assess the value of the local information. The impact-based system could also be a valuable tool to validate the existing hazard-based system, which builds more confidence in its use in informing anticipatory actions. The study findings, therefore, should open avenues for further dialogue on what the impact-based trigger system could mean within the broader forecast-based action landscape toward building the resilience of at-risk communities.
Review and update of the Health of the Nation Outcome Scales for People with Learning Disabilities (HoNOS-LD)
Authors: Painter Jon , Adams Nicola , Ingham Barry , James Michael , Majid Madiha , Roy Ashok , Shankar Rohit , Smith Mark 
Published: May 2023

Background: The Health of the Nation Outcomes Scales for people with Learning Disabilities (HoNOS-LD) is an 18-item measure which provides a structured and standardized approach to rating various clinical and psychosocial outcomes and has been in use nationally since 2002. Aims: To revise and improve the HoNOS-LD’s utility in contemporary intellectual disability (ID) services whilst retaining its original objectives and five-point severity ratings. Method: ID clinicians were invited to complete an online survey, rating each item on the existing measure for being fit for purpose, identifying issues and suggesting improvements based on their experience of using the HoNOS-LD in practice. Scales were then assessed and revised sequentially; survey responses were used to inform discussion and revisions to the HoNOS-LD by the Advisory Board. Results: A total of 75 individuals replied. Respondents had used HoNOS-LD for an average of 8.0 years ( S.D. 5.28 years) and 88% found the scale to be useful in their practice. On average, respondents used HoNOS-LD ratings to inform care 42.4% of the time ( S.D. 33.5%). For each scale there was a significant negative correlation between the percentage of positive/very positive respondent ratings and the number of changes proposed. Common changes included simplifying terms, reducing ambiguity and replacing anachronistic language. Conclusion: The changes outlined in this paper are based on the advisory group’s expert consensus. These changes are intended to improve reliability and validity but now need empirical testing as well as review by service users.
Drop-Set Resistance Training versus Pyramidal and Traditional Sets Elicits Greater Psychophysiological Responses in Men
Authors: Enes Alysson , Oneda Gustavo , Leonel Danilo Fonseca , Ramos Renan Alberton , Kvas-Cabral Vinnicius C. , Bernardo Mauro F. , Escalante Guillermo , Souza-Junior Tácito P. 
Published: May 2023

We compared the effects of resistance training (ResisT) to pyramidal and traditional weightlifting sets on men’s psychophysiological responses. In a randomized crossover design, 24 resistance-trained males performed drop-set, descending pyramid, and traditional ResisT in the barbell back squat, 45° leg press, and seated knee extension. We assessed participants’ rating of perceived exertion (RPE) and feelings of pleasure/displeasure (FPD) at the end of each set and at 10, 15, 20, and 30 minutes post-session. No differences were detected across ResisT Methods in total training volume ( p = 0.180). Post hoc comparisons revealed that drop-set training elicited higher RPE ( M 8.8 SD 0.7 arbitrary units) and lower FPD ( M −1.4 SD 1.5 arbitrary units) values compared to descending pyramid ( M Set RPE 8.0 SD 0.9 arbitrary units and M Set FPD 0.4 SD 1.6 arbitrary units) and traditional set ( M Set RPE 7.5 SD 1.1 arbitrary units and M Set FPD 1.3 SD 1.2 arbitrary units) schemes ( p < 0.05). In addition, drop-set training elicited higher session RPE ( M 8.1 SD 0.8 arbitrary units) and lower session FPD ( M 0.2 SD 1.4 arbitrary units) values than descending pyramid and traditional ResisT ( p < 0.001). Similarly, descending pyramid training elicited higher session RPE ( M 6.6 SD 0.9 arbitrary units) and lower session FPD ( M 1.2 SD 1.4 arbitrary units) than traditional set ( M Session RPE 5.9 SD 0.8 arbitrary units and M Session FPD 1.5 SD 1.2 arbitrary units) training ( p = 0.015). No differences were found in the temporality of post-session metrics, suggesting that testing 10 and 15 minutes post-ResisT was sufficient to assess session RPE ( p = 0.480) and session FPD ( p = 0.855), respectively. In conclusion, even with similar total training volume, drop-set training elicited more pronounced psychophysiological responses than either pyramidal or traditional ResisT in resistance-trained males.
End-of-Life Preferences: A Randomized Trial of Framing Comfort Care as Refusal of Treatment in the Context of COVID-19
Authors: Hodges Juliet S. , Stoyanova Lilia V. , Galizzi Matteo M. 
Published: May 2023

Background Rates of advance directive (AD) completion in the United Kingdom are lower than in the United States and other western European countries, which is especially concerning in light of the COVID-19 pandemic. UK residents typically complete an advance decision to refuse care (ADRT), whereas US versions of ADs present a more neutral choice between comfort-oriented or life-prolonging care. The purpose of this study is to test whether this framing affects decision making for end-of-life care and if this is affected by exposure to information about the COVID-19 pandemic. Methods In an online experiment, 801 UK-based respondents were randomly allocated to document their preferences for end-of-life care in a 2 (US AD or UK ADRT) by 2 (presence or absence of COVID-19 prime) between-subjects factorial design. Results Most (74.8%) of participants across all conditions chose comfort-oriented care. However, framing comfort care as a refusal of treatment made respondents significantly less likely to choose it (65.4% v. 84.1%, P < 0.001). This effect was exacerbated by priming participants to think about COVID-19: those completing an ADRT were significantly more likely to choose life-prolonging care when exposed to the COVID-19 prime (39.8% v. 29.6%, P = 0.032). Subgroup analyses revealed these effects differed by age, with older participants’ choices influenced more by COVID-19 while younger participants were more affected by the AD framing. Conclusions The UK ADRT significantly reduced the proportion of participants choosing comfort-oriented care, an effect that was heightened in the presence of information about COVID-19. This suggests the current way end-of-life care wishes are documented in the United Kingdom could affect people’s choices in a way that does not align with their preferences, especially in the context of the COVID-19 pandemic. Highlights Participants completing an AD framed as an advance decision to refuse treatment were significantly less likely to choose comfort-oriented care than participants completing an AD with a neutral choice between comfort-oriented and life-prolonging care. Exposure to a COVID-19 prime had an interactive effect on documented preferences in the refusal of treatment condition, with these participants even less likely to choose comfort-oriented care. Policy makers and organizations that design templates for advance care planning, particularly in the time of the COVID-19 pandemic, should be aware how the framing of these forms can influence decisions.
A quantitative analysis of long-term follow-up computed tomography of idiopathic pulmonary fibrosis: the correlation with the progression and prognosis
Authors: Kunihiro Yoshie , Matsumoto Tsuneo , Murakami Tomoyuki , Shimokawa Mototsugu , Kamei Haruhito , Tanaka Nobuyuki , Ito Katsuyoshi 
Published: May 2023

Background Quantitative analyses of computed tomography (CT) images using computer-aided detection (CAD) are correlated with visual assessments and pulmonary function test findings and might be useful for predicting the prognosis of patients with idiopathic pulmonary fibrosis (IPF). Purpose To evaluate the association between the quantitative analysis of long-term follow-up CT of IPF and the progression and prognosis. Material and Methods A total of 48 patients with IPF who received over one year of follow-up CT were included in this study. The results of quantitative analyses (emphysema, ground-glass attenuation [GGA], consolidation, reticulation, and honeycombing) using a CAD software program of initial and follow-up CT findings were evaluated, and the association with the progression of the total lesion of IPF and prognosis using Spearman's rank correlation and Cox regression analyses was considered. Results Results of quantitative analyses of consolidation, reticulation, honeycombing, and the total lesion on initial CT were correlated with progressive changes in the total lesion of IPF per year (r = 0.4375, 0.4128, 0.4649, and 0.4095, respectively). The results of quantitative analyses of honeycombing (hazard ratio [HR] = 1.40, 95% confidence interval [CI] = 1.03−1.89, P = 0.0314) and GGA (HR = 0.85, 95% CI = 0.72−0.99, P = 0.0384) at initial CT were prognostic factors according to a multivariate Cox regression analysis. Conclusion The quantitative analysis of honeycombing using a CAD software program of CT findings may be useful for predicting the progression and prognosis of patients with IPF.
Virtual Group Music Therapy for Apathy in Parkinson’s Disease: A Pilot Study
Authors: Shah-Zamora Deepal , Anderson Sharlet , Barton Brandon , Fleisher Jori E. 
Published: May 2023

Objective To evaluate the effect of virtual group music therapy on apathy in people with Parkinson’s disease (PD). Introduction Apathy affects 40% of people with PD, lacks effective therapies, and independently predicts poorer quality of life and greater caregiver burden. Music therapy is the clinical application of music to address a person’s physical or emotional needs and is effective in treating apathy in dementia. Methods People with idiopathic PD and apathy (Movement Disorders Society-Unified Parkinson’s Disease Rating Scale, apathy item ≥ 2) and their caregivers participated in twelve, weekly virtual group music therapy sessions, with session attendance signifying adherence. Participants completed pre- and post-intervention assessments of apathy (Apathy Scale (AS)), quality of life (Parkinson’s Disease Questionnaire-short form), functional ability (Schwab & England Activities of Daily Living Scale), depression (Beck Depression Inventory (BDI-II)), and cognition (Montreal Cognitive Assessment-Blind). Among secondary outcomes, we assessed caregiver burden (Zarit Burden Interview-short form) and strain (Multidimensional Caregiver Strain Index). Results Sixteen PD participants (93.8% men, mean age 68.3 ± 8.4 years, median 6 years PD duration) and their caregivers (93.8% women, mean age 62.6 ± 11 years) completed the study. All PD participants and 88% of caregivers were >70% adherent to the intervention. Apathy (AS, effect size = 0.767, P = 0.002) and depression (BDI-II, effect size = 0.542, P = 0.03) improved, with no change in caregiver measures. Conclusion Group music therapy is an effective treatment for apathy in PD and may improve mood. The virtual format is a feasible alternative to in-person sessions with high adherence and satisfaction.
Monomer elution model of composite resin material
Authors: Petronijevic Sarcev Branislava , Sarcev Ivan , Atanackovic Teodor 
Published: May 2023

As a part of this study, a mathematical model based on two-compartment pharmacokinetic system with general fractional derivatives was developed. Its aim was to describe the release of BisGMA and TEGDMA monomers from composite core resin over three time periods. For this purpose, five Clearfil Photo Core resin samples were prepared and elution was measured using high performance liquid chromatography at 1, 7 and 28 days post-immersion in 75% ethanol. The findings confirmed good model fit to the data related to released monomer quantity.
The Experience of Women From Underrepresented Groups With Urinary Incontinence: A Systematic Review
Authors: Blanco Gutiérrez Verónica , Hundley Vanora A. , Way Susan 
Published: May 2023

Introduction: Urinary incontinence (UI) in women is a global public health issue. However, there is a limited understanding of the experience of women from underrepresented groups suffering from UI. The purpose of this systematic review was to examine current evidence regarding the experience of women with UI from these groups. Methodology: A systematic search was undertaken to retrieve research studies that answered the research question. Four qualitative research studies were included. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guided this review. Results: Four themes emerged from this review: the perceived origin of UI, the physical, psychological, and social impact of UI, the impact of culture and religion on UI, and vice versa, and the interaction of women with health services. Discussion: Social determinants of health, such as religion and culture, need to be considered by professionals providing care if women from underrepresented groups experiencing UI are to receive optimal care.
Three-dimensional Analysis of Facial Asymmetry in Unilateral Lambdoid Craniosynostosis
Authors: Harrison Lucas M. , Ferrari Eliza J. , Mathew Denzil P. , Derderian Christopher A. , Hallac Rami R. 
Published: May 2023

Objective Unilateral lambdoid synostosis (ULS) is characterized by occipital flattening, mastoid bulging, and contralateral parietal bossing. Anterior craniofacial features are less well-defined. This study utilizes volumetric, craniometric, and composite heat maps of three-dimensional (3D) rendered CT scans to analyze anterior craniofacial asymmetry in ULS and compared to controls. Design A retrospective review of three-dimensional CT scans. Setting Tertiary care pediatric institution. Patients, Participants 30 ULS and 30 control patients. Main Outcome Measure(s) Volumetric and craniometric analysis of the anterior fossa, orbits, zygomas, maxilla, and mandible was performed. Results The anterior fossa volume was greater bilaterally (0.047, 0.038), and the fossa angle was more anterior contralaterally (<0.001) and more anterior bilaterally than controls (0.038, 0.033). The orbits had greater height and lesser depth bilaterally compared to controls (0.006, 0.009; < 0.001, < 0.001). Zygoma length was significantly greater on the contralateral side than controls (0.048; < 0.001). Nasal contralateral deviation of 3.57  ±  1.97°. The maxillary length was longer on the contralateral side (0.045). The mandibular angle was more anterior on the ipsilateral side and posterior on the contralateral side (<0.001) compared to controls (0.042, < 0.001). Chin had a contralateral deviation of 1.04  ±  3.74°. Conclusions ULS has significant asymmetry in the anterior craniofacial skeleton. There is a bilateral expansion of the anterior cranial fossa with greater frontal bossing on the contralateral side. Increased orbital height and decreased depth. Contralateral zygomatic and mandibular body lengthening with posterior mandibular deviation. These features may provide more effective diagnosis and potential clinical management strategies.
Commentary: The Legal System Response to Child Maltreatment
Authors: Cross Theodore P. , Block Stephanie D. , Vandervort Frank E. 
Published: May 2023

Legal actions are perhaps the most powerful responses to child maltreatment. Criminal and child protection investigation and forensic interviewing can provide the evidence needed to support a child victim’s disclosure. Prosecution of child maltreatment can hold perpetrators accountable. Juvenile and family court actions can provide for children’s safety and oversee their care in state custody and journey to a permanent home. This commentary introduces readers to a special issue of the journal Child Maltreatment that focuses on the legal system response to child abuse and neglect. We provide an overview of the issue’s 11 research articles and additional commentary. These works provide crucial new knowledge on gaining information from child victims involved in the legal system, on the law enforcement and prosecution response to child maltreatment, and on the legal framework supporting child protection.