SCAview: an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar Ataxias
Authors: Uebachs Mischa , Wegner Philipp , Schaaf Sebastian , Kugai Simon , Jacobi Heike , Kuo Sheng-Han , Ashizawa Tetsuo , Fluck Juliane ,   EUROSCA study group, du Montcel Sophie Tezenas , Bauer Peter , Giunti Paola , Cook Arron , Labrum Robyn , Parkinson Michael H. , Durr Alexandra , Brice Alexis , Charles Perrine , Marelli Cecilia , Mariotti Caterina , Nanetti Lorenzo , Panzeri Marta , Rakowicz Maria , Sulek Anna , Sobanska Anna , Schmitz-Hübsch Tanja , Schöls Ludger , Hengel Holger , Baliko Laszlo , Melegh Bela , Filla Alessandro , Antenora Antonella , Infante Jon , Berciano José , van de Warrenburg Bart P. , Timmann Dagmar , Szymanski Sandra , Boesch Sylvia , Kang Jun-Suk , Pandolfo Massimo , Schulz Jörg B. , Molho Sonia , Diallo Alhassane ,   ESMI study group, Grobe-Einsler Marcus , Önder Demet , Raposo Mafalda , Vasconcelos João , Lima Manuela , de Almeida Luís Pereira , Silva Patrick , Cunha Inês , Giunti Paola , Garcia-Moreno Hector , Manso Katarina , Synofzik Matthis , Hengel Holger , Traschütz Andreas , van de Warrenburg Bart , van Gaalen Judith , Perbolt Tessa , Bushara Khalaf , Hutter Diane , Infante Jon , Manrique Leire , Thieme Andreas , Erdlenbruch Friedrich , Onyike Chiadi , Fishman Ann , Reetz Kathrin , Dogan Imis , Ratai Eva , Schmahmann Jeremy , Santana Magda , Hübener-Schmid Jeannette ,   RISCA study group, du Montcel Sophie Tezenas , Romanzetti Sandro , Harmuth Florian , Mariotti Caterina , Nanetti Lorenzo , Rakowicz Maria , Makowicz Grzegorz , Durr Alexandra , Filla Alessandro , Roca Alessandro , Schöls Ludger , Hengel Holger , Infante Jon , Kang Jun-Suk , Casalo Carlo , Masciullo Marcella , Baliko Laszlo , Melegh Bela , Nachbauer Wolfgang , Bürk-Gergs Katrin , Schulz Jörg B. , Riess Olaf , Reetz Kathrin ,   CRC-SCA study group, Figueroa Karla P. , Perlman Susan L. , Gomez Christopher M. , Wilmot George R. , Schmahmann Jeremy D. , Ying Sarah H. , Zesiewicz Theresa A. , Paulson Henry L. , Shakkottai Vikram G. , Bushara Khalaf , Geschwind Michael D. , Xia Guangbin , Pulst Stefan M. , Subramony Sub H. ,   SCA Registry study group, Grobe-Einsler Marcus , Önder Demet , Koyak Berkan , Reetz Kathrin , Klockgether Thomas , Faber Jennifer 
Published: March 2023

AbstractWith SCAview, we present a prompt and comprehensive tool that enables scientists to browse large datasets of the most common spinocerebellar ataxias intuitively and without technical effort. Basic concept is a visualization of data, with a graphical handling and filtering to select and define subgroups and their comparison. Several plot types to visualize all data points resulting from the selected attributes are provided. The underlying synthetic cohort is based on clinical data from five different European and US longitudinal multicenter cohorts in spinocerebellar ataxia type 1, 2, 3, and 6 (SCA1, 2, 3, and 6) comprising > 1400 patients with overall > 5500 visits. First, we developed a common data model to integrate the clinical, demographic, and characterizing data of each source cohort. Second, the available datasets from each cohort were mapped onto the data model. Third, we created a synthetic cohort based on the cleaned dataset. With SCAview, we demonstrate the feasibility of mapping cohort data from different sources onto a common data model. The resulting browser-based visualization tool with a thoroughly graphical handling of the data offers researchers the unique possibility to visualize relationships and distributions of clinical data, to define subgroups and to further investigate them without any technical effort. Access to SCAview can be requested via the Ataxia Global Initiative and is free of charge.